# --- full sequence ---- --- best 1 domain ---- --- domain number estimation ---- # target name accession query name accession E-value score bias E-value score bias exp reg clu ov env dom rep inc description of target #------------------- ---------- -------------------- ---------- --------- ------ ----- --------- ------ ----- --- --- --- --- --- --- --- --- --------------------- Imm42 PF15593.6 ELR10779.1 - 0.12 12.8 0.0 0.13 12.7 0.0 1.1 1 0 0 1 1 1 0 Immunity protein 42 C2 PF00168.30 ELR10781.1 - 2.5e-20 72.7 0.0 3.1e-20 72.4 0.0 1.0 1 0 0 1 1 1 1 C2 domain IHABP4_N PF16174.5 ELR10782.1 - 0.45 11.1 28.7 1.8 9.2 15.5 2.6 2 0 0 2 2 2 0 Intracellular hyaluronan-binding protein 4 N-terminal Med19 PF10278.9 ELR10782.1 - 5.3 6.9 28.8 0.14 12.1 20.1 2.3 2 0 0 2 2 2 0 Mediator of RNA pol II transcription subunit 19 VPS9 PF02204.18 ELR10784.1 - 5e-19 68.4 0.1 1.1e-18 67.4 0.1 1.6 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain PH PF00169.29 ELR10784.1 - 0.00018 22.0 0.0 0.00034 21.1 0.0 1.5 1 0 0 1 1 1 1 PH domain Neuralized PF07177.12 ELR10785.1 - 0.0075 16.3 0.0 0.012 15.7 0.0 1.2 1 0 0 1 1 1 1 Neuralized F-box-like PF12937.7 ELR10785.1 - 1.5 8.8 4.9 2.3 8.2 0.8 2.8 2 1 0 2 2 2 0 F-box-like Kelch_6 PF13964.6 ELR10786.1 - 0.0011 19.2 1.5 0.15 12.4 0.1 3.7 2 1 1 3 3 3 1 Kelch motif Kelch_4 PF13418.6 ELR10786.1 - 0.024 14.6 14.5 16 5.6 0.1 6.3 6 1 0 6 6 6 0 Galactose oxidase, central domain START PF01852.19 ELR10787.1 - 1.2e-14 54.3 0.6 1.6e-14 53.9 0.6 1.2 1 0 0 1 1 1 1 START domain Prenylcys_lyase PF07156.14 ELR10789.1 - 1.9e-46 158.9 0.1 2.7e-46 158.4 0.1 1.2 1 0 0 1 1 1 1 Prenylcysteine lyase Amino_oxidase PF01593.24 ELR10789.1 - 1.4e-15 57.6 0.0 4.6e-15 55.9 0.0 1.7 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 ELR10789.1 - 0.0036 17.5 0.0 0.016 15.4 0.0 2.1 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Peptidase_M28 PF04389.17 ELR10790.1 - 4.2e-24 85.3 0.0 7.4e-24 84.5 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M28 TFR_dimer PF04253.15 ELR10790.1 - 1.1e-21 77.2 0.0 1.8e-21 76.5 0.0 1.3 1 0 0 1 1 1 1 Transferrin receptor-like dimerisation domain PA PF02225.22 ELR10790.1 - 2.6e-10 40.2 0.0 1.6e-09 37.7 0.0 2.2 2 0 0 2 2 2 1 PA domain Nicastrin PF05450.15 ELR10790.1 - 0.0029 17.1 0.0 0.0066 15.9 0.0 1.5 1 0 0 1 1 1 1 Nicastrin V-SNARE_C PF12352.8 ELR10792.1 - 2.2e-12 47.1 1.1 2.2e-12 47.1 1.1 2.1 2 0 0 2 2 2 1 Snare region anchored in the vesicle membrane C-terminus Sec20 PF03908.13 ELR10792.1 - 0.088 12.7 0.2 0.87 9.5 0.0 2.4 1 1 2 3 3 3 0 Sec20 PARP PF00644.20 ELR10793.1 - 4.2e-09 36.3 1.5 2.3e-08 33.8 0.3 2.1 1 1 1 2 2 2 1 Poly(ADP-ribose) polymerase catalytic domain Exotox-A_cataly PF09009.10 ELR10793.1 - 0.032 14.0 0.0 0.049 13.4 0.0 1.2 1 0 0 1 1 1 0 Exotoxin A catalytic MMR_HSR1 PF01926.23 ELR10794.1 - 8.7e-18 64.5 0.0 1.3e-17 63.9 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 ELR10794.1 - 4.3e-07 29.6 0.0 5.6e-07 29.2 0.0 1.1 1 0 0 1 1 1 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 ELR10794.1 - 2.5e-05 24.3 0.0 2.8e-05 24.1 0.0 1.3 1 0 0 1 1 1 1 RsgA GTPase SRPRB PF09439.10 ELR10794.1 - 0.00076 19.0 0.0 0.001 18.6 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Dynamin_N PF00350.23 ELR10794.1 - 0.0012 18.9 1.9 0.02 15.0 0.3 2.4 1 1 1 2 2 2 1 Dynamin family AAA_29 PF13555.6 ELR10794.1 - 0.002 17.8 0.0 0.035 13.8 0.0 2.2 2 0 0 2 2 2 1 P-loop containing region of AAA domain Roc PF08477.13 ELR10794.1 - 0.037 14.3 0.0 0.053 13.7 0.0 1.3 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase ABC_tran PF00005.27 ELR10794.1 - 0.054 14.0 0.0 0.086 13.4 0.0 1.3 1 0 0 1 1 1 0 ABC transporter AAA_28 PF13521.6 ELR10794.1 - 0.078 13.2 0.1 0.63 10.3 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_15 PF13175.6 ELR10794.1 - 0.13 11.9 0.0 0.18 11.5 0.0 1.1 1 0 0 1 1 1 0 AAA ATPase domain PduV-EutP PF10662.9 ELR10794.1 - 0.17 11.6 0.0 0.29 10.9 0.0 1.4 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation IIGP PF05049.13 ELR10794.1 - 0.21 10.6 0.0 0.29 10.2 0.0 1.2 1 0 0 1 1 1 0 Interferon-inducible GTPase (IIGP) EF-hand_1 PF00036.32 ELR10795.1 - 5.2e-08 31.9 0.1 1.5e-05 24.2 0.0 2.3 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 ELR10795.1 - 5.8e-08 32.0 0.1 2.6e-05 23.8 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.6 ELR10795.1 - 6.2e-08 33.0 0.2 1e-07 32.3 0.2 1.2 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.6 ELR10795.1 - 4.2e-07 29.2 2.2 3e-06 26.5 0.1 2.2 2 0 0 2 2 2 1 EF hand EF-hand_8 PF13833.6 ELR10795.1 - 0.00013 21.7 0.7 0.00026 20.8 0.3 1.7 1 1 1 2 2 2 1 EF-hand domain pair RR_TM4-6 PF06459.12 ELR10796.1 - 0.015 15.2 3.8 0.017 15.0 3.8 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Trypan_PARP PF05887.11 ELR10796.1 - 0.074 13.0 1.3 0.089 12.8 1.3 1.1 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) Vfa1 PF08432.10 ELR10796.1 - 0.18 12.1 7.8 0.26 11.6 7.8 1.3 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 DUF2151 PF10221.9 ELR10796.1 - 0.25 9.9 3.4 0.27 9.8 3.4 1.0 1 0 0 1 1 1 0 Cell cycle and development regulator RPN2_C PF18004.1 ELR10796.1 - 0.7 9.8 5.9 0.97 9.3 5.9 1.2 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain Nop14 PF04147.12 ELR10796.1 - 1.3 7.1 14.0 1.5 6.9 14.0 1.0 1 0 0 1 1 1 0 Nop14-like family NPR3 PF03666.13 ELR10796.1 - 1.5 7.5 6.3 1.8 7.3 6.3 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 SURF2 PF05477.11 ELR10796.1 - 2.4 7.8 10.9 2.7 7.6 10.9 1.1 1 0 0 1 1 1 0 Surfeit locus protein 2 (SURF2) Presenilin PF01080.17 ELR10796.1 - 8 5.1 5.6 9.1 4.9 5.6 1.0 1 0 0 1 1 1 0 Presenilin MecA PF05389.12 ELR10797.1 - 0.0052 16.5 1.3 0.0055 16.4 1.3 1.1 1 0 0 1 1 1 1 Negative regulator of genetic competence (MecA) Lectin_N PF03954.14 ELR10798.1 - 0.094 12.5 1.6 0.13 12.0 1.6 1.2 1 0 0 1 1 1 0 Hepatic lectin, N-terminal domain Glyco_hydro_53 PF07745.13 ELR10799.1 - 0.078 11.9 0.3 0.14 11.1 0.3 1.3 1 0 0 1 1 1 0 Glycosyl hydrolase family 53 Myosin_head PF00063.21 ELR10801.1 - 4.6e-240 798.5 0.0 5.7e-240 798.1 0.0 1.1 1 0 0 1 1 1 1 Myosin head (motor domain) MyTH4 PF00784.17 ELR10801.1 - 4.1e-39 133.4 0.0 6.2e-18 65.3 0.0 2.7 2 0 0 2 2 2 2 MyTH4 domain SH3_2 PF07653.17 ELR10801.1 - 5.2e-11 42.1 0.0 1e-10 41.1 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 ELR10801.1 - 1.3e-10 40.7 0.0 2.7e-10 39.7 0.0 1.6 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 ELR10801.1 - 3.7e-07 29.9 0.0 8e-07 28.8 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain FERM_M PF00373.18 ELR10801.1 - 7.4e-05 23.1 0.0 0.00021 21.6 0.0 1.8 1 0 0 1 1 1 1 FERM central domain AAA_16 PF13191.6 ELR10801.1 - 0.0028 18.1 0.0 0.0083 16.5 0.0 1.8 1 0 0 1 1 1 1 AAA ATPase domain IQ PF00612.27 ELR10801.1 - 0.0039 16.9 2.7 0.0096 15.6 2.7 1.7 1 0 0 1 1 1 1 IQ calmodulin-binding motif RA PF00788.23 ELR10801.1 - 0.018 15.6 0.0 0.067 13.8 0.0 1.9 2 0 0 2 2 2 0 Ras association (RalGDS/AF-6) domain Rrn6 PF10214.9 ELR10801.1 - 0.034 12.7 0.0 0.05 12.1 0.0 1.2 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor MyTH4 PF00784.17 ELR10802.1 - 3.3e-23 82.3 0.0 9.6e-23 80.7 0.0 1.8 2 0 0 2 2 2 1 MyTH4 domain FERM_M PF00373.18 ELR10802.1 - 1.1e-12 48.4 0.1 2.1e-12 47.5 0.1 1.4 1 0 0 1 1 1 1 FERM central domain FERM_M PF00373.18 ELR10803.1 - 2.4e-12 47.3 0.0 4.5e-12 46.4 0.0 1.4 1 0 0 1 1 1 1 FERM central domain FRG1 PF06229.12 ELR10804.1 - 5.7e-13 49.0 0.1 0.00011 22.0 0.0 3.0 1 1 2 3 3 3 3 FRG1-like domain Fascin PF06268.13 ELR10804.1 - 1.4e-12 47.8 0.1 7.8e-08 32.5 0.0 3.1 2 1 1 3 3 3 2 Fascin domain RicinB_lectin_2 PF14200.6 ELR10804.1 - 0.0015 19.2 0.2 0.27 12.0 0.0 3.0 1 1 3 4 4 4 2 Ricin-type beta-trefoil lectin domain-like Vps62 PF06101.11 ELR10805.1 - 4.5e-06 25.3 0.0 5.1e-06 25.1 0.0 1.1 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 62 RhoGEF PF00621.20 ELR10807.1 - 4.4e-36 124.8 0.0 6.9e-36 124.2 0.0 1.3 1 0 0 1 1 1 1 RhoGEF domain Pyr_redox_2 PF07992.14 ELR10808.1 - 3.1e-35 121.8 0.2 4.9e-35 121.2 0.2 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase DEP PF00610.21 ELR10808.1 - 2.6e-12 46.6 0.0 5.3e-12 45.6 0.0 1.6 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) Pyr_redox PF00070.27 ELR10808.1 - 4.1e-11 43.3 2.6 3.1e-05 24.4 0.1 3.2 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 ELR10808.1 - 5.1e-08 32.4 0.0 0.00035 19.8 0.0 2.2 2 0 0 2 2 2 2 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_3 PF13738.6 ELR10808.1 - 7e-08 32.1 0.0 7.6e-05 22.1 0.0 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 ELR10808.1 - 0.0011 19.0 1.4 11 6.0 0.0 4.1 3 1 1 4 4 4 1 FAD-NAD(P)-binding DUF1188 PF06690.11 ELR10808.1 - 0.0016 18.0 0.0 0.003 17.1 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1188) NAD_binding_7 PF13241.6 ELR10808.1 - 0.0018 18.7 0.1 0.37 11.2 0.0 2.5 2 0 0 2 2 2 1 Putative NAD(P)-binding TrkA_N PF02254.18 ELR10808.1 - 0.0022 18.3 0.5 1.8 8.8 0.0 2.7 2 0 0 2 2 2 2 TrkA-N domain 3HCDH_N PF02737.18 ELR10808.1 - 0.0051 16.7 0.6 1.2 9.0 0.1 2.3 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Sacchrp_dh_NADP PF03435.18 ELR10808.1 - 0.0097 16.2 0.3 3.2 8.0 0.0 2.4 2 0 0 2 2 2 1 Saccharopine dehydrogenase NADP binding domain DAO PF01266.24 ELR10808.1 - 0.03 13.9 1.1 0.13 11.8 0.0 2.5 3 0 0 3 3 3 0 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 ELR10808.1 - 0.039 14.2 0.1 0.3 11.4 0.0 2.2 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain Lycopene_cycl PF05834.12 ELR10808.1 - 0.063 12.3 0.1 8.5 5.3 0.0 2.3 2 0 0 2 2 2 0 Lycopene cyclase protein HI0933_like PF03486.14 ELR10808.1 - 0.081 11.6 0.3 5.4 5.6 0.0 2.9 3 0 0 3 3 3 0 HI0933-like protein GIDA PF01134.22 ELR10808.1 - 0.098 11.7 0.8 5.7 5.9 0.0 3.1 4 0 0 4 4 4 0 Glucose inhibited division protein A PLDc_2 PF13091.6 ELR10809.1 - 1.1e-33 116.0 0.0 1.3e-25 89.8 0.0 2.2 2 0 0 2 2 2 2 PLD-like domain PLDc PF00614.22 ELR10809.1 - 1.3e-08 34.7 0.6 0.00064 19.8 0.0 2.5 2 0 0 2 2 2 2 Phospholipase D Active site motif BRCA2 PF00634.18 ELR10810.1 - 3.9e-06 26.4 0.0 6.3e-06 25.8 0.0 1.3 1 0 0 1 1 1 1 BRCA2 repeat CBS PF00571.28 ELR10811.1 - 1e-26 93.1 0.0 1.7e-10 41.2 0.1 4.1 4 0 0 4 4 4 4 CBS domain SNF2_N PF00176.23 ELR10812.1 - 1.6e-68 231.0 0.1 1.9e-61 207.7 0.1 2.2 2 0 0 2 2 2 2 SNF2 family N-terminal domain Helicase_C PF00271.31 ELR10812.1 - 1.6e-14 54.2 0.0 4e-14 52.9 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain zf-RING_UBOX PF13445.6 ELR10812.1 - 2.5e-08 33.8 1.4 4.6e-08 33.0 0.8 1.8 1 1 0 1 1 1 1 RING-type zinc-finger zf-RING_2 PF13639.6 ELR10812.1 - 4.1e-07 30.2 3.6 8.8e-07 29.2 3.6 1.6 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 ELR10812.1 - 5.4e-07 29.4 3.0 1e-06 28.5 3.0 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 ELR10812.1 - 1.9e-06 27.6 1.8 4e-06 26.6 1.8 1.5 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ELR10812.1 - 2.3e-06 27.5 2.7 4e-06 26.7 2.7 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_2 PF13923.6 ELR10812.1 - 2.1e-05 24.2 1.6 2.1e-05 24.2 1.6 2.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 ELR10812.1 - 6.2e-05 22.8 4.7 0.00049 19.9 4.7 2.1 1 1 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.6 ELR10812.1 - 0.0021 18.2 3.1 0.0051 16.9 3.1 1.7 1 1 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_11 PF17123.5 ELR10812.1 - 0.043 13.6 3.1 0.12 12.2 3.1 1.8 1 0 0 1 1 1 0 RING-like zinc finger Tmpp129 PF10272.9 ELR10812.1 - 0.13 11.5 0.9 0.2 10.9 0.9 1.2 1 0 0 1 1 1 0 Putative transmembrane protein precursor DDHD PF02862.17 ELR10812.1 - 2.3 8.3 4.7 6.7 6.8 1.4 2.4 2 0 0 2 2 2 0 DDHD domain CDC45 PF02724.14 ELR10812.1 - 3.8 5.7 11.3 0.3 9.3 5.4 1.9 2 0 0 2 2 2 0 CDC45-like protein EBV-NA3 PF05009.12 ELR10812.1 - 7.4 6.0 8.6 15 5.0 5.0 2.5 2 0 0 2 2 2 0 Epstein-Barr virus nuclear antigen 3 (EBNA-3) Use1 PF09753.9 ELR10813.1 - 0.0094 15.7 0.0 0.01 15.6 0.0 1.1 1 0 0 1 1 1 1 Membrane fusion protein Use1 SNARE PF05739.19 ELR10813.1 - 0.045 13.8 1.1 0.28 11.2 1.1 2.1 1 1 0 1 1 1 0 SNARE domain SQHop_cyclase_C PF13243.6 ELR10814.1 - 3.6e-67 226.7 3.9 1.6e-58 198.4 3.1 3.0 2 1 1 3 3 3 2 Squalene-hopene cyclase C-terminal domain SQHop_cyclase_N PF13249.6 ELR10814.1 - 7.5e-49 166.4 0.8 4.1e-39 134.4 0.0 4.6 3 1 2 5 5 5 5 Squalene-hopene cyclase N-terminal domain Prenyltrans PF00432.21 ELR10814.1 - 9.5e-40 134.0 3.8 2.6e-12 46.3 0.3 5.9 6 0 0 6 6 6 5 Prenyltransferase and squalene oxidase repeat Pec_lyase PF09492.10 ELR10814.1 - 0.00029 20.3 0.3 9.2 5.5 0.0 4.2 2 2 1 3 3 3 3 Pectic acid lyase TED_complement PF07678.14 ELR10814.1 - 0.0021 17.1 0.6 0.011 14.8 0.0 2.5 3 0 0 3 3 3 1 A-macroglobulin TED domain DUF982 PF06169.12 ELR10814.1 - 0.097 12.7 0.4 0.65 10.1 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF982) A_deamin PF02137.18 ELR10815.1 - 4.6e-72 243.2 0.0 6.2e-71 239.5 0.0 2.4 1 1 0 1 1 1 1 Adenosine-deaminase (editase) domain SR-25 PF10500.9 ELR10815.1 - 0.0029 17.3 12.9 0.0059 16.2 12.9 1.4 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein DUF4667 PF15700.5 ELR10815.1 - 0.63 10.1 12.0 0.94 9.5 11.2 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4667) SOG2 PF10428.9 ELR10815.1 - 3.8 6.6 11.5 4.9 6.2 11.5 1.2 1 0 0 1 1 1 0 RAM signalling pathway protein Apt1 PF10351.9 ELR10815.1 - 3.8 6.3 5.4 5.4 5.8 5.4 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain Chorion_2 PF03964.15 ELR10815.1 - 4.4 8.2 12.4 13 6.7 12.4 1.9 1 0 0 1 1 1 0 Chorion family 2 CCSAP PF15748.5 ELR10815.1 - 5.8 7.0 11.5 9.4 6.3 11.5 1.3 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated Ras PF00071.22 ELR10816.1 - 1.2e-07 31.5 0.0 1.4e-07 31.3 0.0 1.0 1 0 0 1 1 1 1 Ras family MyTH4 PF00784.17 ELR10817.1 - 1.8e-19 70.2 0.0 2.8e-19 69.6 0.0 1.3 1 0 0 1 1 1 1 MyTH4 domain RA PF00788.23 ELR10817.1 - 0.0034 18.0 0.0 0.0059 17.2 0.0 1.3 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain Nrap_D5 PF17406.2 ELR10818.1 - 8.6e-32 110.1 0.3 6.7e-28 97.5 0.3 2.2 1 1 0 1 1 1 1 Nrap protein PAP/OAS1-like domain 5 Nrap_D6 PF17407.2 ELR10818.1 - 1.7e-27 96.3 0.0 3.6e-27 95.2 0.0 1.6 1 0 0 1 1 1 1 Nrap protein domain 6 Nrap_D4 PF17405.2 ELR10818.1 - 3.1e-20 72.5 0.1 8.3e-20 71.1 0.0 1.7 2 0 0 2 2 2 1 Nrap protein nucleotidyltransferase domain 4 Pro-kuma_activ PF09286.11 ELR10819.1 - 1.6e-23 83.5 0.2 2.8e-23 82.8 0.2 1.3 1 0 0 1 1 1 1 Pro-kumamolisin, activation domain Peptidase_S8 PF00082.22 ELR10819.1 - 2.7e-06 26.9 2.1 4.8e-06 26.1 2.1 1.3 1 0 0 1 1 1 1 Subtilase family SSF PF00474.17 ELR10820.1 - 3.1e-90 303.0 30.5 1.4e-76 258.0 18.2 2.7 2 1 0 2 2 2 2 Sodium:solute symporter family DUF5056 PF16479.5 ELR10820.1 - 3.7 7.9 6.5 1.6 9.0 0.4 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF5056) Pyr_redox_2 PF07992.14 ELR10821.1 - 6e-36 124.2 0.1 7.6e-36 123.8 0.1 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase DEP PF00610.21 ELR10821.1 - 6.1e-25 87.1 0.0 1.1e-24 86.2 0.0 1.5 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) Pyr_redox PF00070.27 ELR10821.1 - 1.7e-09 38.1 0.1 0.001 19.6 0.0 2.5 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 ELR10821.1 - 8.1e-07 28.6 0.1 5.4e-05 22.6 0.0 2.2 1 1 1 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 ELR10821.1 - 5.7e-05 22.4 0.0 0.048 12.8 0.0 2.3 2 0 0 2 2 2 2 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_9 PF13454.6 ELR10821.1 - 8.8e-05 22.5 1.3 0.53 10.3 0.0 3.5 3 0 0 3 3 3 2 FAD-NAD(P)-binding DUF1188 PF06690.11 ELR10821.1 - 9.8e-05 22.0 0.0 0.00018 21.2 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1188) NAD_binding_7 PF13241.6 ELR10821.1 - 0.00052 20.4 0.2 0.043 14.2 0.1 2.7 2 0 0 2 2 2 1 Putative NAD(P)-binding Trp_halogenase PF04820.14 ELR10821.1 - 0.00073 18.5 0.2 0.012 14.5 0.0 2.3 3 0 0 3 3 3 1 Tryptophan halogenase NAD_binding_8 PF13450.6 ELR10821.1 - 0.0028 17.9 0.4 0.022 15.0 0.1 2.6 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Lycopene_cycl PF05834.12 ELR10821.1 - 0.0028 16.8 0.1 0.2 10.7 0.0 2.2 2 0 0 2 2 2 1 Lycopene cyclase protein DAO PF01266.24 ELR10821.1 - 0.0049 16.5 4.6 0.032 13.8 0.0 2.9 2 1 0 2 2 2 1 FAD dependent oxidoreductase FAD_binding_3 PF01494.19 ELR10821.1 - 0.0087 15.3 0.9 0.75 9.0 0.0 2.2 2 0 0 2 2 2 1 FAD binding domain 3HCDH_N PF02737.18 ELR10821.1 - 0.021 14.7 0.1 7.8 6.3 0.1 2.5 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Sacchrp_dh_NADP PF03435.18 ELR10821.1 - 0.039 14.2 1.5 0.91 9.8 0.0 2.7 3 0 0 3 3 2 0 Saccharopine dehydrogenase NADP binding domain TrkA_N PF02254.18 ELR10821.1 - 0.041 14.2 3.5 0.18 12.1 0.1 2.9 3 0 0 3 3 3 0 TrkA-N domain AlaDh_PNT_C PF01262.21 ELR10821.1 - 0.045 13.0 0.4 1.7 7.9 0.0 2.6 3 0 0 3 3 3 0 Alanine dehydrogenase/PNT, C-terminal domain GIDA PF01134.22 ELR10821.1 - 0.055 12.5 1.7 2.5 7.1 0.3 2.8 3 1 0 3 3 3 0 Glucose inhibited division protein A HI0933_like PF03486.14 ELR10821.1 - 0.14 10.8 0.4 7.3 5.2 0.1 2.5 2 0 0 2 2 2 0 HI0933-like protein Peripla_BP_6 PF13458.6 ELR10822.1 - 3.5e-06 26.9 2.5 2.6e-05 24.0 0.1 2.3 1 1 1 2 2 2 1 Periplasmic binding protein PD40 PF07676.12 ELR10822.1 - 0.011 15.7 1.8 2.2 8.3 0.2 4.1 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat Pkinase_Tyr PF07714.17 ELR10823.1 - 1.1e-121 405.0 0.0 4.1e-63 213.1 0.0 3.2 3 0 0 3 3 3 3 Protein tyrosine kinase Pkinase PF00069.25 ELR10823.1 - 1.3e-109 365.6 0.0 9.7e-59 198.9 0.0 2.3 2 0 0 2 2 2 2 Protein kinase domain PBP_like_2 PF12849.7 ELR10823.1 - 3.3e-15 56.5 19.3 8.8e-12 45.3 2.1 2.3 2 0 0 2 2 2 2 PBP superfamily domain Guanylate_cyc PF00211.20 ELR10823.1 - 1.4e-05 24.8 0.0 3.5e-05 23.5 0.0 1.5 1 1 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain APH PF01636.23 ELR10823.1 - 0.00028 20.9 0.1 0.055 13.4 0.0 2.5 2 0 0 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.14 ELR10823.1 - 0.008 15.5 0.2 4.3 6.6 0.1 2.3 2 0 0 2 2 2 2 Lipopolysaccharide kinase (Kdo/WaaP) family EGF_2 PF07974.13 ELR10823.1 - 0.0082 16.5 11.0 0.016 15.6 11.0 1.5 1 0 0 1 1 1 1 EGF-like domain Pkinase_fungal PF17667.1 ELR10823.1 - 0.02 13.7 0.0 0.098 11.4 0.0 1.9 2 0 0 2 2 2 0 Fungal protein kinase Haspin_kinase PF12330.8 ELR10823.1 - 0.062 12.2 0.0 0.13 11.2 0.0 1.4 1 0 0 1 1 1 0 Haspin like kinase domain Kinase-like PF14531.6 ELR10823.1 - 0.086 12.1 0.0 0.5 9.6 0.0 2.0 2 0 0 2 2 2 0 Kinase-like DUF3718 PF12514.8 ELR10823.1 - 0.1 12.8 0.1 0.59 10.3 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3718) RIO1 PF01163.22 ELR10823.1 - 0.17 11.5 0.6 3 7.4 0.1 2.3 2 0 0 2 2 2 0 RIO1 family IPTL-CTERM PF18203.1 ELR10823.1 - 1.7 8.6 3.9 6.2 6.8 3.9 2.1 1 0 0 1 1 1 0 IPTL-CTERM motif Kelch_4 PF13418.6 ELR10824.1 - 2.1e-43 146.1 7.4 4.4e-11 42.6 0.1 6.7 6 0 0 6 6 6 6 Galactose oxidase, central domain Kelch_5 PF13854.6 ELR10824.1 - 5.6e-30 102.8 7.1 7.9e-06 25.7 0.1 7.0 7 0 0 7 7 7 5 Kelch motif Kelch_3 PF13415.6 ELR10824.1 - 7.7e-30 102.6 4.8 3.6e-09 36.7 0.0 7.5 7 2 0 7 7 7 5 Galactose oxidase, central domain Kelch_1 PF01344.25 ELR10824.1 - 4.9e-29 99.6 4.9 5.3e-07 29.1 0.0 6.5 6 0 0 6 6 6 4 Kelch motif Kelch_6 PF13964.6 ELR10824.1 - 2.4e-28 97.4 5.0 7.7e-06 26.0 0.0 6.8 7 0 0 7 7 7 5 Kelch motif Kelch_2 PF07646.15 ELR10824.1 - 1.4e-17 62.9 15.5 0.00053 19.9 0.0 6.0 6 0 0 6 6 6 5 Kelch motif F-box-like PF12937.7 ELR10824.1 - 2.2e-09 37.0 0.6 2.2e-09 37.0 0.6 2.2 2 0 0 2 2 2 1 F-box-like RAG2 PF03089.14 ELR10824.1 - 0.00054 19.0 0.0 1.5 7.8 0.0 3.5 3 1 0 3 3 3 2 Recombination activating protein 2 F-box PF00646.33 ELR10824.1 - 0.29 11.0 6.3 0.051 13.5 1.0 2.3 2 1 0 2 2 2 0 F-box domain DUF2452 PF10504.9 ELR10827.1 - 0.063 12.7 0.0 0.092 12.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2452) Ank_4 PF13637.6 ELR10830.1 - 9.6e-32 109.0 0.2 6.5e-09 36.2 0.0 4.4 1 1 4 5 5 5 5 Ankyrin repeats (many copies) Ank_5 PF13857.6 ELR10830.1 - 5.1e-29 100.0 5.8 7.1e-09 35.8 0.0 4.6 1 1 3 4 4 4 4 Ankyrin repeats (many copies) Ank_2 PF12796.7 ELR10830.1 - 1e-28 99.8 0.8 9.5e-19 67.8 0.0 3.2 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank PF00023.30 ELR10830.1 - 1.5e-23 82.1 1.2 0.00027 21.2 0.0 4.9 4 0 0 4 4 4 4 Ankyrin repeat Ank_3 PF13606.6 ELR10830.1 - 2e-20 70.7 1.4 0.00013 22.1 0.0 5.2 5 0 0 5 5 5 4 Ankyrin repeat RhoGAP PF00620.27 ELR10830.1 - 1.3e-08 34.8 0.0 3.1e-08 33.6 0.0 1.5 1 0 0 1 1 1 1 RhoGAP domain F-box-like PF12937.7 ELR10830.1 - 0.00078 19.3 0.1 0.0018 18.1 0.1 1.6 1 0 0 1 1 1 1 F-box-like DUF4988 PF16378.5 ELR10830.1 - 0.012 15.3 0.0 0.023 14.3 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function F-box PF00646.33 ELR10830.1 - 0.054 13.4 0.2 0.28 11.1 0.0 2.1 2 0 0 2 2 2 0 F-box domain Pap_E4 PF02711.14 ELR10834.1 - 0.04 14.9 0.1 0.072 14.1 0.1 1.4 1 0 0 1 1 1 0 E4 protein PH_12 PF16457.5 ELR10834.1 - 0.17 12.4 0.2 0.22 12.0 0.1 1.3 1 1 0 1 1 1 0 Pleckstrin homology domain MORN PF02493.20 ELR10835.1 - 6.8e-100 321.4 141.8 2e-07 30.5 0.1 19.4 19 0 0 19 19 19 19 MORN repeat PP2C PF00481.21 ELR10836.1 - 5.1e-13 49.2 0.0 1.5e-06 28.1 0.0 2.3 2 0 0 2 2 2 2 Protein phosphatase 2C PP2C_2 PF13672.6 ELR10836.1 - 4.9e-06 26.3 3.0 3.6e-05 23.5 0.0 2.3 2 0 0 2 2 2 1 Protein phosphatase 2C SpoIIE PF07228.12 ELR10836.1 - 0.00011 22.1 0.1 0.00017 21.6 0.1 1.3 1 0 0 1 1 1 1 Stage II sporulation protein E (SpoIIE) L51_S25_CI-B8 PF05047.16 ELR10837.1 - 2.1e-11 43.6 0.0 3.2e-11 43.0 0.0 1.3 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain DNA_methylase PF00145.17 ELR10839.1 - 2.8e-20 72.9 0.0 1.9e-10 40.6 0.0 3.0 3 0 0 3 3 3 3 C-5 cytosine-specific DNA methylase SR-25 PF10500.9 ELR10840.1 - 0.0053 16.4 0.1 0.0053 16.4 0.1 2.2 2 0 0 2 2 2 1 Nuclear RNA-splicing-associated protein DUF5308 PF17233.2 ELR10840.1 - 0.016 15.5 1.0 0.63 10.3 0.7 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5308) mit_SMPDase PF14724.6 ELR10840.1 - 3.5 5.5 3.8 4.7 5.1 3.8 1.1 1 0 0 1 1 1 0 Mitochondrial-associated sphingomyelin phosphodiesterase PPR_2 PF13041.6 ELR10841.1 - 8.4e-13 48.3 0.0 0.0004 20.5 0.0 5.1 6 0 0 6 6 6 2 PPR repeat family PPR_1 PF12854.7 ELR10841.1 - 3.8e-09 36.1 1.9 0.043 13.5 0.0 5.1 6 0 0 6 6 6 2 PPR repeat PPR_3 PF13812.6 ELR10841.1 - 4.3e-08 33.1 0.1 0.034 14.2 0.0 4.1 5 1 0 5 5 5 2 Pentatricopeptide repeat domain PPR PF01535.20 ELR10841.1 - 2.2e-06 27.5 3.1 1.6 9.2 0.0 7.4 8 0 0 8 8 8 1 PPR repeat PPR_long PF17177.4 ELR10841.1 - 0.00056 19.3 0.1 3.4 7.0 0.0 4.4 5 1 0 5 5 5 1 Pentacotripeptide-repeat region of PRORP ECSIT PF06239.11 ELR10841.1 - 0.0047 16.1 0.0 0.033 13.3 0.0 2.3 3 0 0 3 3 3 1 Evolutionarily conserved signalling intermediate in Toll pathway DUF1382 PF07131.11 ELR10841.1 - 0.12 12.4 0.1 0.36 10.9 0.1 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1382) SUIM_assoc PF16619.5 ELR10841.1 - 0.46 10.6 9.0 1.9 8.6 0.7 3.0 2 1 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 DUF2715 PF10895.8 ELR10841.1 - 1.3 8.6 5.5 2.3 7.8 5.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF2715) Mpv17_PMP22 PF04117.12 ELR10842.1 - 1.4e-24 86.1 1.8 2.5e-24 85.3 1.8 1.4 1 0 0 1 1 1 1 Mpv17 / PMP22 family Folate_carrier PF01770.18 ELR10842.1 - 0.19 10.4 0.5 0.26 10.0 0.5 1.1 1 0 0 1 1 1 0 Reduced folate carrier Pkinase PF00069.25 ELR10843.1 - 9.1e-64 215.4 0.0 2.8e-63 213.7 0.0 1.8 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR10843.1 - 5.7e-46 156.9 0.0 9.7e-46 156.1 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 ELR10843.1 - 0.00015 20.7 0.1 0.00049 19.0 0.0 1.7 2 0 0 2 2 2 1 Fungal protein kinase Haspin_kinase PF12330.8 ELR10843.1 - 0.061 12.3 0.0 6.9 5.5 0.0 2.1 2 0 0 2 2 2 0 Haspin like kinase domain EXOSC1 PF10447.9 ELR10845.1 - 2.7e-14 53.7 0.9 1.1e-10 42.0 0.0 2.3 1 1 1 2 2 2 2 Exosome component EXOSC1/CSL4 ECR1_N PF14382.6 ELR10845.1 - 6.7e-14 51.4 1.6 1.1e-13 50.7 0.6 1.9 2 0 0 2 2 2 1 Exosome complex exonuclease RRP4 N-terminal region S1 PF00575.23 ELR10845.1 - 0.0014 18.9 0.3 0.071 13.5 0.3 2.9 3 0 0 3 3 3 1 S1 RNA binding domain FAT PF02259.23 ELR10846.1 - 1.5e-42 146.0 0.0 3.3e-42 144.9 0.0 1.6 1 0 0 1 1 1 1 FAT domain PI3_PI4_kinase PF00454.27 ELR10846.1 - 3.3e-15 56.6 0.0 6.4e-15 55.6 0.0 1.4 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase FATC PF02260.20 ELR10846.1 - 0.00014 21.6 2.3 0.00032 20.4 0.0 2.6 2 0 0 2 2 2 1 FATC domain HEAT_EZ PF13513.6 ELR10847.1 - 0.037 14.6 5.1 11 6.7 0.0 6.7 7 0 0 7 7 7 0 HEAT-like repeat RIX1 PF08167.12 ELR10847.1 - 4.1 7.1 6.7 11 5.7 0.1 4.0 3 1 1 4 4 4 0 rRNA processing/ribosome biogenesis Profilin PF00235.19 ELR10848.1 - 1.5e-07 31.7 0.0 1.6e-07 31.6 0.0 1.1 1 0 0 1 1 1 1 Profilin SH3_15 PF18346.1 ELR10848.1 - 0.11 12.8 0.0 0.21 11.9 0.0 1.4 1 0 0 1 1 1 0 Mind bomb SH3 repeat domain Robl_LC7 PF03259.17 ELR10848.1 - 0.13 12.0 0.0 0.28 11.0 0.0 1.5 1 0 0 1 1 1 0 Roadblock/LC7 domain TRM13 PF05206.14 ELR10849.1 - 1.3e-53 182.2 0.0 1.5e-53 182.0 0.0 1.0 1 0 0 1 1 1 1 Methyltransferase TRM13 zf-U11-48K PF05253.12 ELR10850.1 - 6.2e-08 32.4 5.4 1.2e-07 31.4 5.4 1.6 1 0 0 1 1 1 1 U11-48K-like CHHC zinc finger TRM13 PF05206.14 ELR10850.1 - 0.0022 17.6 0.0 0.0036 16.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase TRM13 Cupin_8 PF13621.6 ELR10851.1 - 5.2e-29 101.7 0.0 8.8e-29 101.0 0.0 1.3 1 1 0 1 1 1 1 Cupin-like domain JmjC PF02373.22 ELR10851.1 - 0.00079 19.8 0.0 0.0075 16.7 0.0 2.1 1 1 0 1 1 1 1 JmjC domain, hydroxylase TPR_1 PF00515.28 ELR10852.1 - 4.5e-34 114.9 4.5 4.9e-07 29.3 0.2 8.7 9 0 0 9 9 9 5 Tetratricopeptide repeat TPR_2 PF07719.17 ELR10852.1 - 2.1e-30 102.3 13.3 1.6e-05 24.7 0.4 9.9 10 0 0 10 10 10 5 Tetratricopeptide repeat TPR_16 PF13432.6 ELR10852.1 - 2.6e-24 85.6 6.2 4.4e-10 40.1 0.2 7.8 8 1 1 9 9 9 3 Tetratricopeptide repeat TPR_8 PF13181.6 ELR10852.1 - 1.6e-20 71.5 0.0 0.026 14.7 0.0 7.7 8 0 0 8 8 8 4 Tetratricopeptide repeat TPR_12 PF13424.6 ELR10852.1 - 1.2e-19 70.4 13.6 3.1e-05 24.2 0.3 7.6 7 1 0 8 8 7 4 Tetratricopeptide repeat TPR_14 PF13428.6 ELR10852.1 - 4.2e-17 61.4 15.4 0.0015 19.2 1.1 9.9 7 2 3 10 10 10 3 Tetratricopeptide repeat TPR_11 PF13414.6 ELR10852.1 - 3e-16 58.8 0.2 1.1e-07 31.4 0.0 8.0 5 2 4 9 9 9 3 TPR repeat TPR_19 PF14559.6 ELR10852.1 - 8e-14 51.9 7.2 0.0031 18.0 0.2 7.8 5 3 4 9 9 9 2 Tetratricopeptide repeat TPR_7 PF13176.6 ELR10852.1 - 1.3e-10 40.6 11.1 0.034 14.2 0.0 7.4 8 0 0 8 8 6 3 Tetratricopeptide repeat TPR_17 PF13431.6 ELR10852.1 - 4.3e-09 36.1 2.8 0.29 11.6 0.0 6.7 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_9 PF13371.6 ELR10852.1 - 1.2e-07 31.7 5.5 0.00076 19.6 0.1 4.5 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_10 PF13374.6 ELR10852.1 - 1.6e-07 30.9 10.1 0.27 11.2 0.3 6.7 7 0 0 7 7 6 3 Tetratricopeptide repeat ANAPC3 PF12895.7 ELR10852.1 - 2.1e-05 24.6 17.1 0.64 10.3 0.3 7.3 5 1 3 8 8 8 1 Anaphase-promoting complex, cyclosome, subunit 3 TOM20_plant PF06552.12 ELR10852.1 - 0.01 15.6 0.2 9.2 6.0 0.0 3.2 2 1 1 3 3 3 0 Plant specific mitochondrial import receptor subunit TOM20 TPR_6 PF13174.6 ELR10852.1 - 0.012 16.2 15.6 11 6.9 0.1 7.6 9 0 0 9 9 7 0 Tetratricopeptide repeat TPR_15 PF13429.6 ELR10852.1 - 0.013 14.7 1.9 4.3 6.5 0.0 4.0 4 1 0 5 5 5 0 Tetratricopeptide repeat Foie-gras_1 PF11817.8 ELR10852.1 - 0.026 14.1 0.3 0.4 10.2 0.1 2.8 3 0 0 3 3 3 0 Foie gras liver health family 1 TPR_4 PF07721.14 ELR10852.1 - 0.043 14.5 11.8 55 4.8 2.4 6.5 6 0 0 6 6 5 0 Tetratricopeptide repeat Peptidase_Mx PF15887.5 ELR10852.1 - 0.14 11.6 0.3 0.55 9.6 0.1 1.9 2 0 0 2 2 2 0 Putative zinc-binding metallo-peptidase Nucleo_P87 PF07267.11 ELR10852.1 - 0.7 8.7 8.0 1.1 8.1 8.0 1.2 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 DPM3 PF08285.11 ELR10853.1 - 0.025 14.8 0.1 0.03 14.5 0.1 1.1 1 0 0 1 1 1 0 Dolichol-phosphate mannosyltransferase subunit 3 (DPM3) RasGEF PF00617.19 ELR10854.1 - 2.7e-06 27.7 0.0 3.4e-06 27.4 0.0 1.1 1 0 0 1 1 1 1 RasGEF domain Ras PF00071.22 ELR10855.1 - 2.2e-50 170.4 0.0 2.6e-50 170.2 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR10855.1 - 4.1e-19 69.0 0.0 6.1e-19 68.4 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR10855.1 - 1.7e-07 30.8 0.0 2.4e-07 30.4 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family AAA_7 PF12775.7 ELR10855.1 - 0.022 14.3 0.0 0.033 13.7 0.0 1.2 1 0 0 1 1 1 0 P-loop containing dynein motor region RasGEF PF00617.19 ELR10856.1 - 3.9e-33 115.1 0.1 6e-33 114.5 0.1 1.2 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 ELR10856.1 - 4e-19 68.8 0.0 7.2e-19 68.0 0.0 1.4 1 0 0 1 1 1 1 RasGEF N-terminal motif SH3_1 PF00018.28 ELR10856.1 - 3e-07 29.9 0.0 6.1e-07 28.9 0.0 1.6 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 ELR10856.1 - 6.4e-07 29.0 0.0 1.2e-06 28.0 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.6 ELR10856.1 - 8.5e-06 25.5 0.0 1.7e-05 24.6 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain Sec61_beta PF03911.16 ELR10857.1 - 0.00013 21.9 3.9 0.00013 21.9 3.9 2.1 2 0 0 2 2 2 1 Sec61beta family Use1 PF09753.9 ELR10857.1 - 0.042 13.6 0.3 0.05 13.3 0.3 1.1 1 0 0 1 1 1 0 Membrane fusion protein Use1 Nop PF01798.18 ELR10858.1 - 1.5e-88 296.1 0.1 1.5e-88 296.1 0.1 2.1 2 0 0 2 2 2 1 snoRNA binding domain, fibrillarin NOP5NT PF08156.13 ELR10858.1 - 1.1e-18 67.3 0.1 1.1e-18 67.3 0.1 2.9 2 0 0 2 2 2 1 NOP5NT (NUC127) domain RNA_polI_A34 PF08208.11 ELR10858.1 - 0.053 13.6 38.2 0.1 12.7 38.2 1.4 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 DUF4604 PF15377.6 ELR10858.1 - 0.23 11.9 31.4 0.57 10.6 31.4 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4604) DUF4758 PF15950.5 ELR10858.1 - 0.64 10.3 3.7 1.5 9.1 3.7 1.7 1 0 0 1 1 1 0 Putative sperm flagellar membrane protein DDHD PF02862.17 ELR10858.1 - 9.4 6.3 13.4 18 5.4 13.4 1.4 1 0 0 1 1 1 0 DDHD domain HEAT PF02985.22 ELR10859.1 - 8.3e-13 47.4 5.0 0.11 12.8 0.1 8.1 8 0 0 8 8 8 4 HEAT repeat HEAT_2 PF13646.6 ELR10859.1 - 2.1e-12 47.3 7.0 0.012 16.0 0.8 6.3 4 2 2 6 6 6 5 HEAT repeats Cnd1 PF12717.7 ELR10859.1 - 7.4e-09 35.9 9.4 0.001 19.1 1.3 4.9 3 2 1 4 4 4 3 non-SMC mitotic condensation complex subunit 1 Adaptin_N PF01602.20 ELR10859.1 - 6.5e-06 25.0 5.3 0.048 12.2 0.2 3.5 2 1 1 3 3 3 3 Adaptin N terminal region Proteasom_PSMB PF10508.9 ELR10859.1 - 0.0002 20.0 6.2 0.0015 17.1 1.3 2.2 2 0 0 2 2 2 2 Proteasome non-ATPase 26S subunit MMS19_N PF14500.6 ELR10859.1 - 0.068 12.7 4.8 2.3 7.7 0.4 3.0 2 2 1 3 3 3 0 Dos2-interacting transcription regulator of RNA-Pol-II ECH_1 PF00378.20 ELR10859.1 - 0.12 11.6 0.1 0.22 10.8 0.1 1.4 1 0 0 1 1 1 0 Enoyl-CoA hydratase/isomerase RTP1_C1 PF10363.9 ELR10859.1 - 0.51 10.5 3.1 11 6.2 1.2 3.6 2 1 0 2 2 2 0 Required for nuclear transport of RNA pol II C-terminus 1 HEAT_EZ PF13513.6 ELR10859.1 - 6.1 7.5 9.0 3.1 8.4 0.0 4.7 4 1 1 5 5 5 0 HEAT-like repeat Sulfate_transp PF00916.20 ELR10860.1 - 8.5e-36 123.5 0.5 8.5e-36 123.5 0.5 1.5 2 0 0 2 2 2 1 Sulfate permease family STAS PF01740.21 ELR10860.1 - 7.8e-18 64.2 0.0 1.2e-17 63.6 0.0 1.3 1 0 0 1 1 1 1 STAS domain MFS_MOT1 PF16983.5 ELR10860.1 - 1.8 9.0 9.2 0.091 13.2 3.4 1.8 2 0 0 2 2 2 0 Molybdate transporter of MFS superfamily Sulfate_transp PF00916.20 ELR10861.1 - 4.3e-101 338.4 14.4 4.3e-101 338.4 14.4 1.4 2 0 0 2 2 2 1 Sulfate permease family STAS PF01740.21 ELR10861.1 - 2.1e-17 62.8 0.0 3.4e-17 62.1 0.0 1.3 1 0 0 1 1 1 1 STAS domain MrpF_PhaF PF04066.13 ELR10861.1 - 0.026 14.9 0.6 0.026 14.9 0.6 4.4 4 0 0 4 4 4 0 Multiple resistance and pH regulation protein F (MrpF / PhaF) SPESP1 PF15754.5 ELR10862.1 - 0.0062 15.8 0.7 0.013 14.7 0.7 1.4 1 1 0 1 1 1 1 Sperm equatorial segment protein 1 SMRP1 PF15181.6 ELR10862.1 - 0.0084 15.7 0.2 0.015 14.9 0.1 1.5 1 1 1 2 2 2 1 Spermatid-specific manchette-related protein 1 Ig_5 PF16681.5 ELR10862.1 - 0.041 14.3 0.0 0.085 13.3 0.0 1.6 1 0 0 1 1 1 0 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Phage_TAC_6 PF09550.10 ELR10862.1 - 0.072 13.5 0.0 0.21 12.1 0.0 1.7 1 0 0 1 1 1 0 Phage tail assembly chaperone protein, TAC Helicase_C PF00271.31 ELR10863.1 - 2e-08 34.5 0.0 6.8e-08 32.8 0.0 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain RNase_HII PF01351.18 ELR10864.1 - 2.7e-28 99.2 0.0 3.5e-28 98.8 0.0 1.1 1 0 0 1 1 1 1 Ribonuclease HII NmrA PF05368.13 ELR10866.1 - 0.0025 17.4 0.0 0.0035 16.9 0.0 1.2 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 ELR10866.1 - 0.006 16.5 0.0 0.015 15.2 0.0 1.6 2 0 0 2 2 2 1 NAD(P)H-binding Pkinase PF00069.25 ELR10868.1 - 8.3e-24 84.4 0.0 1.3e-23 83.8 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain PHD PF00628.29 ELR10868.1 - 3.4e-07 30.1 14.3 3.4e-07 30.1 14.3 2.1 3 0 0 3 3 2 1 PHD-finger Pkinase_Tyr PF07714.17 ELR10868.1 - 4.2e-06 26.2 0.0 7.2e-06 25.5 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ELR10868.1 - 5.3e-05 22.7 0.0 8.6e-05 22.0 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 ELR10868.1 - 0.00012 21.0 0.0 0.00012 21.0 0.0 2.4 2 1 1 3 3 2 1 Fungal protein kinase APH_6_hur PF04655.14 ELR10868.1 - 0.0016 17.9 0.3 0.0055 16.1 0.1 1.9 2 1 0 2 2 2 1 Aminoglycoside/hydroxyurea antibiotic resistance kinase Choline_kinase PF01633.20 ELR10868.1 - 0.0027 17.3 0.0 0.0048 16.5 0.0 1.4 1 0 0 1 1 1 1 Choline/ethanolamine kinase CDC45 PF02724.14 ELR10868.1 - 0.0039 15.6 12.0 0.0053 15.1 12.0 1.1 1 0 0 1 1 1 1 CDC45-like protein Coilin_N PF15862.5 ELR10868.1 - 0.0048 16.7 3.7 0.0075 16.1 3.7 1.4 1 0 0 1 1 1 1 Coilin N-terminus APH PF01636.23 ELR10868.1 - 0.0064 16.4 3.6 0.0074 16.2 0.1 2.4 2 1 1 3 3 3 1 Phosphotransferase enzyme family zf-HC5HC2H_2 PF13832.6 ELR10868.1 - 0.012 15.7 3.3 0.045 13.9 3.3 1.9 1 0 0 1 1 1 0 PHD-zinc-finger like domain RIO1 PF01163.22 ELR10868.1 - 0.031 13.9 2.0 0.033 13.8 0.0 2.0 2 0 0 2 2 1 0 RIO1 family MCM_bind PF09739.9 ELR10868.1 - 0.26 9.7 5.1 0.35 9.3 5.1 1.1 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor Presenilin PF01080.17 ELR10868.1 - 7.8 5.2 11.1 11 4.7 11.1 1.1 1 0 0 1 1 1 0 Presenilin PHD_4 PF16866.5 ELR10868.1 - 9.7 6.4 15.1 3.5 7.8 11.3 2.2 2 0 0 2 2 1 0 PHD-finger DNA_repr_REX1B PF14966.6 ELR10869.1 - 3e-12 47.0 6.9 2.8e-10 40.7 5.4 2.5 2 1 0 2 2 2 1 DNA repair REX1-B APG6_N PF17675.1 ELR10869.1 - 0.16 12.5 9.3 0.23 12.0 9.3 1.4 1 1 0 1 1 1 0 Apg6 coiled-coil region PCRF PF03462.18 ELR10869.1 - 0.2 11.5 5.9 0.12 12.2 2.2 1.9 1 1 1 2 2 2 0 PCRF domain DUF4404 PF14357.6 ELR10869.1 - 0.25 12.0 3.3 0.97 10.1 0.2 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4404) kleA_kleC PF17383.2 ELR10869.1 - 0.5 10.7 6.9 0.2 12.0 2.4 2.3 1 1 1 2 2 2 0 Uncharacterized KorC regulated protein A Jnk-SapK_ap_N PF09744.9 ELR10869.1 - 1.5 9.0 11.3 0.15 12.3 3.3 2.1 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 AAA_23 PF13476.6 ELR10869.1 - 5.3 7.5 6.5 8.3 6.8 6.5 1.5 1 1 0 1 1 1 0 AAA domain PARP PF00644.20 ELR10870.1 - 3.7e-67 225.7 0.0 6.9e-67 224.8 0.0 1.5 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain PARP_reg PF02877.14 ELR10870.1 - 3e-47 160.1 0.2 5.6e-47 159.3 0.2 1.5 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase, regulatory domain WGR PF05406.15 ELR10870.1 - 3.2e-29 100.8 1.0 6.9e-29 99.7 1.0 1.6 1 0 0 1 1 1 1 WGR domain BRCT PF00533.26 ELR10870.1 - 5e-06 26.8 0.0 1.1e-05 25.7 0.0 1.6 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain PTCB-BRCT PF12738.7 ELR10870.1 - 0.00033 20.6 0.0 0.0007 19.5 0.0 1.6 1 0 0 1 1 1 1 twin BRCT domain Hydrolase_6 PF13344.6 ELR10871.1 - 2.2e-31 107.9 0.0 7.4e-31 106.3 0.0 1.8 2 0 0 2 2 2 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 ELR10871.1 - 3.4e-20 71.9 0.0 6e-20 71.1 0.0 1.4 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase PF00702.26 ELR10871.1 - 7.5e-13 49.3 0.1 1.5e-12 48.2 0.1 1.8 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 ELR10871.1 - 6.4e-10 39.4 0.0 8.2e-05 22.8 0.0 2.4 3 0 0 3 3 3 2 Haloacid dehalogenase-like hydrolase GBR_NSP5 PF17580.2 ELR10871.1 - 0.024 14.5 0.0 0.039 13.8 0.0 1.3 1 0 0 1 1 1 0 Group B Rotavirus Non-structural protein 5 PGP_phosphatase PF09419.10 ELR10871.1 - 0.062 12.9 0.0 2.6 7.6 0.0 2.3 2 0 0 2 2 2 0 Mitochondrial PGP phosphatase ThiF PF00899.21 ELR10872.1 - 1.4e-22 80.2 0.0 5.9e-22 78.2 0.0 1.9 1 1 0 1 1 1 1 ThiF family E1_4HB PF16191.5 ELR10872.1 - 0.0048 17.0 0.2 10 6.4 0.0 4.0 4 1 0 4 4 4 1 Ubiquitin-activating enzyme E1 four-helix bundle DpnII PF04556.12 ELR10872.1 - 0.14 11.4 0.0 0.23 10.7 0.0 1.2 1 0 0 1 1 1 0 DpnII restriction endonuclease DUF2726 PF10881.8 ELR10873.1 - 0.085 12.8 0.1 0.12 12.2 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2726) Pkinase PF00069.25 ELR10874.1 - 7.4e-40 137.0 0.0 1e-39 136.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR10874.1 - 1.5e-20 73.6 0.0 5.3e-20 71.8 0.0 1.7 1 1 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 ELR10874.1 - 0.00013 21.4 0.5 0.00017 21.0 0.5 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 ELR10874.1 - 0.014 14.2 0.0 0.1 11.3 0.1 2.0 2 0 0 2 2 2 0 Fungal protein kinase 5_nucleotid PF05761.14 ELR10874.1 - 0.1 11.5 0.1 0.13 11.2 0.1 1.1 1 0 0 1 1 1 0 5' nucleotidase family FlxA PF14282.6 ELR10875.1 - 0.033 14.2 9.4 0.038 14.0 6.3 2.1 2 0 0 2 2 2 0 FlxA-like protein NuDC PF16273.5 ELR10875.1 - 0.035 14.6 16.4 0.035 14.6 16.4 3.1 3 1 1 4 4 4 0 Nuclear distribution C domain DUF572 PF04502.13 ELR10875.1 - 0.099 12.2 9.5 0.16 11.6 9.5 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF572) TFIIA PF03153.13 ELR10875.1 - 0.17 11.8 12.7 0.22 11.5 12.7 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Borrelia_P83 PF05262.11 ELR10875.1 - 0.22 10.0 8.9 0.21 10.0 8.9 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein Plasmodium_Vir PF05795.11 ELR10875.1 - 0.65 9.4 4.5 0.69 9.3 4.5 1.2 1 0 0 1 1 1 0 Plasmodium vivax Vir protein DUF724 PF05266.14 ELR10875.1 - 0.74 9.6 8.2 1.2 8.9 8.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF724) OAD_gamma PF04277.13 ELR10875.1 - 0.83 10.3 3.6 2.6 8.7 1.1 2.3 2 0 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain DUF4407 PF14362.6 ELR10875.1 - 1.6 8.0 6.4 1.9 7.7 6.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Casc1_N PF15927.5 ELR10875.1 - 6.4 6.4 22.9 11 5.7 22.9 1.4 1 0 0 1 1 1 0 Cancer susceptibility candidate 1 N-terminus NPR3 PF03666.13 ELR10875.1 - 6.7 5.4 7.8 7.2 5.3 7.8 1.3 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 2OG-FeII_Oxy PF03171.20 ELR10876.1 - 0.00011 22.7 0.0 0.00016 22.1 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily GDP_Man_Dehyd PF16363.5 ELR10878.1 - 9.7e-09 35.1 0.0 1.1e-08 34.9 0.0 1.1 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 ELR10878.1 - 1.7e-07 30.9 0.0 1.8e-07 30.9 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NmrA PF05368.13 ELR10878.1 - 6.9e-07 29.0 0.1 1.1e-06 28.4 0.1 1.2 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 ELR10878.1 - 3.5e-05 23.8 0.2 4.8e-05 23.3 0.2 1.5 1 1 0 1 1 1 1 NAD(P)H-binding 3Beta_HSD PF01073.19 ELR10878.1 - 0.00068 18.7 0.0 0.00068 18.7 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.12 ELR10878.1 - 0.012 14.8 0.0 0.013 14.7 0.0 1.2 1 0 0 1 1 1 0 Male sterility protein adh_short PF00106.25 ELR10878.1 - 0.045 13.2 0.1 0.058 12.8 0.1 1.2 1 0 0 1 1 1 0 short chain dehydrogenase AA_kinase PF00696.28 ELR10878.1 - 0.17 11.5 0.3 0.28 10.8 0.4 1.5 1 1 0 1 1 1 0 Amino acid kinase family Epimerase PF01370.21 ELR10879.1 - 0.04 13.4 0.0 0.053 13.0 0.0 1.2 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family AAA_12 PF13087.6 ELR10880.1 - 4.4e-59 199.5 0.0 4.4e-59 199.5 0.0 3.4 5 0 0 5 5 2 1 AAA domain AAA_11 PF13086.6 ELR10880.1 - 8e-44 150.4 0.2 8e-44 150.4 0.2 8.4 2 2 2 4 4 1 1 AAA domain AAA_19 PF13245.6 ELR10880.1 - 3.7e-09 37.1 0.1 1.1e-08 35.5 0.1 1.9 1 1 0 1 1 1 1 AAA domain Viral_helicase1 PF01443.18 ELR10880.1 - 1.4e-05 24.9 3.5 0.21 11.3 0.0 4.0 4 0 0 4 4 3 3 Viral (Superfamily 1) RNA helicase PhoH PF02562.16 ELR10880.1 - 0.0005 19.6 0.0 0.0028 17.1 0.0 2.0 2 0 0 2 2 2 1 PhoH-like protein AAA_5 PF07728.14 ELR10880.1 - 0.00091 19.2 0.0 0.0057 16.7 0.0 2.2 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 ELR10880.1 - 0.0027 18.1 7.3 0.0045 17.4 0.1 3.8 2 0 0 2 2 2 1 AAA ATPase domain PIF1 PF05970.14 ELR10880.1 - 0.0046 16.2 0.0 0.024 13.8 0.0 1.9 2 0 0 2 2 2 1 PIF1-like helicase AAA_25 PF13481.6 ELR10880.1 - 0.0076 15.8 0.0 0.0076 15.8 0.0 2.4 3 0 0 3 3 3 1 AAA domain Mg_chelatase PF01078.21 ELR10880.1 - 0.014 14.8 0.1 0.12 11.7 0.0 2.2 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_22 PF13401.6 ELR10880.1 - 0.022 15.0 0.0 0.1 12.8 0.0 2.2 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 ELR10880.1 - 0.036 14.0 0.1 0.094 12.6 0.1 1.7 1 0 0 1 1 1 0 NACHT domain AAA PF00004.29 ELR10880.1 - 0.058 13.8 3.3 0.071 13.5 0.1 2.5 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) DEAD PF00270.29 ELR10880.1 - 0.13 12.0 0.0 0.25 11.1 0.0 1.4 1 0 0 1 1 1 0 DEAD/DEAH box helicase ResIII PF04851.15 ELR10880.1 - 0.4 10.7 0.0 0.4 10.7 0.0 4.3 4 0 0 4 4 3 0 Type III restriction enzyme, res subunit Ank_4 PF13637.6 ELR10881.1 - 2.7e-42 142.6 7.9 6e-07 29.9 0.0 10.2 8 3 4 12 12 12 9 Ankyrin repeats (many copies) Ank_2 PF12796.7 ELR10881.1 - 8.1e-42 141.7 3.7 3.4e-09 37.2 0.0 7.2 3 2 4 8 8 8 6 Ankyrin repeats (3 copies) Ank_3 PF13606.6 ELR10881.1 - 2.8e-35 116.3 15.4 4.4e-05 23.6 0.0 13.5 14 0 0 14 14 14 8 Ankyrin repeat Ank_5 PF13857.6 ELR10881.1 - 7.2e-31 105.9 22.1 4.5e-07 30.0 0.4 11.9 9 4 4 13 13 13 6 Ankyrin repeats (many copies) Ank PF00023.30 ELR10881.1 - 2.7e-27 94.0 23.9 0.00019 21.7 0.2 11.7 12 0 0 12 12 12 7 Ankyrin repeat F-box-like PF12937.7 ELR10881.1 - 1.5e-07 31.2 0.0 3e-07 30.2 0.0 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ELR10881.1 - 0.00054 19.8 0.0 0.00099 18.9 0.0 1.5 1 0 0 1 1 1 1 F-box domain F-box_4 PF15966.5 ELR10881.1 - 0.06 13.2 0.0 0.11 12.3 0.0 1.4 1 0 0 1 1 1 0 F-box C2 PF00168.30 ELR10882.1 - 1.9e-21 76.2 0.0 4e-21 75.2 0.0 1.6 1 0 0 1 1 1 1 C2 domain PH PF00169.29 ELR10882.1 - 1.7e-14 54.2 0.4 6.8e-09 36.2 0.2 3.3 2 1 0 2 2 2 2 PH domain SnoaL_2 PF12680.7 ELR10882.1 - 1.8e-07 31.8 0.0 7.1e-07 29.8 0.0 2.2 1 0 0 1 1 1 1 SnoaL-like domain SnoaL PF07366.12 ELR10882.1 - 0.0011 18.7 0.0 0.0032 17.3 0.0 1.8 1 0 0 1 1 1 1 SnoaL-like polyketide cyclase PH_11 PF15413.6 ELR10882.1 - 0.031 14.7 3.8 0.04 14.3 0.1 2.9 3 0 0 3 3 3 0 Pleckstrin homology domain NARP1 PF12569.8 ELR10882.1 - 1.9 7.3 10.4 0.035 13.0 1.1 2.1 2 0 0 2 2 2 0 NMDA receptor-regulated protein 1 GST_C_3 PF14497.6 ELR10883.1 - 5.2e-19 68.3 0.0 7.2e-19 67.8 0.0 1.2 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 ELR10883.1 - 6.7e-11 42.3 0.0 9.8e-11 41.7 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 ELR10883.1 - 2.3e-07 30.8 0.1 4.8e-07 29.7 0.1 1.8 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 ELR10883.1 - 0.00019 21.7 0.0 0.17 12.2 0.0 2.5 1 1 1 2 2 2 2 Glutathione S-transferase, N-terminal domain GST_C_6 PF17171.4 ELR10883.1 - 0.033 14.0 0.0 0.06 13.1 0.0 1.4 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain PA28_alpha PF02251.18 ELR10883.1 - 0.036 14.1 0.1 0.065 13.3 0.1 1.3 1 0 0 1 1 1 0 Proteasome activator pa28 alpha subunit Rhodanese PF00581.20 ELR10884.1 - 3e-10 40.6 0.0 5.2e-10 39.8 0.0 1.4 1 0 0 1 1 1 1 Rhodanese-like domain BTB PF00651.31 ELR10885.1 - 3.5e-14 53.0 0.0 7.3e-14 51.9 0.0 1.6 1 0 0 1 1 1 1 BTB/POZ domain PH PF00169.29 ELR10885.1 - 7.7e-06 26.4 0.0 2.8e-05 24.6 0.0 2.0 1 1 0 1 1 1 1 PH domain PLDc_2 PF13091.6 ELR10886.1 - 4.7e-15 55.7 0.1 6.5e-15 55.2 0.1 1.2 1 0 0 1 1 1 1 PLD-like domain FAM83 PF07894.12 ELR10886.1 - 4.7e-09 36.2 0.1 5.7e-09 35.9 0.1 1.2 1 0 0 1 1 1 1 FAM83 A-H DUF4763 PF15960.5 ELR10886.1 - 0.055 12.8 0.3 0.085 12.1 0.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4763) GHL6 PF14871.6 ELR10886.1 - 0.09 12.9 0.0 0.16 12.1 0.0 1.5 1 0 0 1 1 1 0 Hypothetical glycosyl hydrolase 6 Chal_sti_synt_N PF00195.19 ELR10887.1 - 2.4e-41 141.6 0.0 3.5e-41 141.1 0.0 1.2 1 0 0 1 1 1 1 Chalcone and stilbene synthases, N-terminal domain Chal_sti_synt_C PF02797.15 ELR10887.1 - 2.4e-27 95.8 0.0 4e-27 95.1 0.0 1.3 1 0 0 1 1 1 1 Chalcone and stilbene synthases, C-terminal domain ACP_syn_III PF08545.10 ELR10887.1 - 3.9e-08 33.0 0.1 7.1e-08 32.2 0.1 1.4 1 0 0 1 1 1 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III ACP_syn_III_C PF08541.10 ELR10887.1 - 3.3e-06 27.2 0.0 1.2e-05 25.4 0.0 1.9 3 0 0 3 3 3 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal FAE1_CUT1_RppA PF08392.12 ELR10887.1 - 2.8e-05 23.6 0.0 4.2e-05 23.0 0.0 1.2 1 0 0 1 1 1 1 FAE1/Type III polyketide synthase-like protein PEP_mutase PF13714.6 ELR10888.1 - 6.1e-19 68.4 0.0 7.4e-19 68.1 0.0 1.1 1 0 0 1 1 1 1 Phosphoenolpyruvate phosphomutase Ribul_P_3_epim PF00834.19 ELR10888.1 - 0.13 11.6 0.0 0.15 11.4 0.0 1.3 1 1 0 1 1 1 0 Ribulose-phosphate 3 epimerase family PEP_mutase PF13714.6 ELR10889.1 - 4.6e-33 114.7 0.0 7.4e-33 114.0 0.0 1.3 1 0 0 1 1 1 1 Phosphoenolpyruvate phosphomutase L27 PF02828.16 ELR10889.1 - 0.004 16.9 0.0 0.0088 15.8 0.0 1.5 1 0 0 1 1 1 1 L27 domain ICL PF00463.21 ELR10889.1 - 0.0048 15.5 0.0 0.0063 15.1 0.0 1.3 1 0 0 1 1 1 1 Isocitrate lyase family PEP_hydrolase PF09370.10 ELR10889.1 - 0.02 14.1 0.0 0.044 13.0 0.0 1.6 1 1 0 1 1 1 0 Phosphoenolpyruvate hydrolase-like IreB PF06135.12 ELR10889.1 - 0.16 12.2 0.0 0.66 10.2 0.0 2.0 2 0 0 2 2 2 0 IreB regulatory phosphoprotein Synapsin_C PF02750.14 ELR10890.1 - 2.3e-49 167.7 0.0 3.8e-49 167.0 0.0 1.3 1 0 0 1 1 1 1 Synapsin, ATP binding domain Synapsin PF02078.16 ELR10890.1 - 4.1e-19 68.7 0.0 9.5e-19 67.6 0.0 1.7 1 0 0 1 1 1 1 Synapsin, N-terminal domain Dsh_C PF12316.8 ELR10890.1 - 1.6 9.1 8.9 2.4 8.5 8.9 1.2 1 0 0 1 1 1 0 Segment polarity protein dishevelled (Dsh) C terminal Trypan_PARP PF05887.11 ELR10890.1 - 5.2 7.0 16.9 9.9 6.1 16.9 1.4 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) CDC45 PF02724.14 ELR10890.1 - 5.2 5.2 16.1 6.6 4.9 16.1 1.1 1 0 0 1 1 1 0 CDC45-like protein Presenilin PF01080.17 ELR10890.1 - 9.1 4.9 14.6 12 4.5 14.6 1.1 1 0 0 1 1 1 0 Presenilin Peptidase_M64 PF09471.10 ELR10891.1 - 3.1e-28 99.0 0.0 1.4e-27 96.9 0.0 1.9 1 1 0 1 1 1 1 IgA Peptidase M64 Acetyltransf_CG PF14542.6 ELR10892.1 - 2.2e-22 79.0 0.0 2.7e-22 78.7 0.0 1.1 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase Acetyltransf_1 PF00583.25 ELR10892.1 - 0.0071 16.6 0.0 0.0084 16.3 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family HATPase_c PF02518.26 ELR10893.1 - 3.1e-26 92.1 0.0 5.5e-26 91.3 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 ELR10893.1 - 1.9e-22 79.6 0.2 4.1e-22 78.5 0.0 1.7 2 0 0 2 2 2 1 Response regulator receiver domain HisKA PF00512.25 ELR10893.1 - 2.6e-14 53.0 0.2 1.4e-13 50.7 0.1 2.2 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain HATPase_c_2 PF13581.6 ELR10893.1 - 0.018 15.0 0.0 0.056 13.4 0.0 1.8 1 0 0 1 1 1 0 Histidine kinase-like ATPase domain HATPase_c_3 PF13589.6 ELR10893.1 - 0.076 12.8 0.0 0.13 12.0 0.0 1.4 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Actin PF00022.19 ELR10895.1 - 1.1e-47 162.5 0.0 1.4e-47 162.3 0.0 1.0 1 0 0 1 1 1 1 Actin Mito_carr PF00153.27 ELR10896.1 - 5.9e-81 266.5 13.7 9.6e-23 79.9 0.1 7.2 6 1 0 6 6 6 6 Mitochondrial carrier protein Sporozoite_P67 PF05642.11 ELR10896.1 - 0.28 9.2 4.0 0.44 8.6 4.0 1.2 1 0 0 1 1 1 0 Sporozoite P67 surface antigen CCDC24 PF15669.5 ELR10896.1 - 5.5 6.8 4.9 8.7 6.1 3.0 1.9 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 24 family F-box-like PF12937.7 ELR10897.1 - 7.7e-06 25.7 1.6 1.7e-05 24.6 0.1 2.1 2 0 0 2 2 2 1 F-box-like DUF1905 PF08922.11 ELR10897.1 - 0.0083 16.2 0.0 0.025 14.7 0.0 1.9 1 1 0 1 1 1 1 Domain of unknown function (DUF1905) DUF4388 PF14332.6 ELR10897.1 - 0.18 12.1 0.0 0.36 11.1 0.0 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4388) RTC PF01137.21 ELR10898.1 - 5.1e-45 153.4 0.1 6.8e-45 153.0 0.1 1.1 1 0 0 1 1 1 1 RNA 3'-terminal phosphate cyclase RTC_insert PF05189.13 ELR10898.1 - 1e-14 54.9 0.3 2e-14 54.0 0.3 1.5 1 0 0 1 1 1 1 RNA 3'-terminal phosphate cyclase (RTC), insert domain Hydrophobin PF01185.18 ELR10898.1 - 0.035 14.7 0.7 0.076 13.6 0.2 1.8 2 0 0 2 2 2 0 Fungal hydrophobin SH3_16 PF18348.1 ELR10898.1 - 0.2 11.5 0.3 20 5.1 0.1 2.5 2 0 0 2 2 2 0 Bacterial dipeptidyl-peptidase Sh3 domain Lzipper-MIP1 PF14389.6 ELR10899.1 - 0.014 15.6 2.8 0.019 15.2 2.8 1.2 1 0 0 1 1 1 0 Leucine-zipper of ternary complex factor MIP1 Lebercilin PF15619.6 ELR10899.1 - 0.057 13.1 1.0 0.073 12.7 1.0 1.1 1 0 0 1 1 1 0 Ciliary protein causing Leber congenital amaurosis disease Spc7 PF08317.11 ELR10899.1 - 0.099 11.5 0.2 0.12 11.2 0.2 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein ABC_tran PF00005.27 ELR10900.1 - 1.3e-28 100.2 0.0 2.3e-28 99.4 0.0 1.4 1 0 0 1 1 1 1 ABC transporter ABC2_membrane PF01061.24 ELR10900.1 - 2.9e-27 95.5 6.6 4.1e-19 68.8 0.8 2.3 1 1 1 2 2 2 2 ABC-2 type transporter T2SSE PF00437.20 ELR10900.1 - 1.8e-05 23.9 0.7 0.00054 19.1 0.1 2.2 2 0 0 2 2 2 1 Type II/IV secretion system protein AAA_16 PF13191.6 ELR10900.1 - 8.3e-05 23.0 0.0 0.00014 22.3 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain RsgA_GTPase PF03193.16 ELR10900.1 - 0.00031 20.7 0.1 0.00062 19.7 0.1 1.4 1 0 0 1 1 1 1 RsgA GTPase AAA_25 PF13481.6 ELR10900.1 - 0.00035 20.2 0.0 0.00058 19.5 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_21 PF13304.6 ELR10900.1 - 0.0013 18.6 0.6 0.5 10.1 0.1 2.4 1 1 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_30 PF13604.6 ELR10900.1 - 0.0017 18.1 0.0 0.0028 17.4 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_28 PF13521.6 ELR10900.1 - 0.003 17.8 0.0 0.0064 16.8 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_23 PF13476.6 ELR10900.1 - 0.0039 17.7 0.1 0.013 16.0 0.1 1.8 1 0 0 1 1 1 1 AAA domain DUF87 PF01935.17 ELR10900.1 - 0.0041 17.3 0.2 0.0076 16.4 0.2 1.3 1 0 0 1 1 1 1 Helicase HerA, central domain NACHT PF05729.12 ELR10900.1 - 0.0056 16.6 0.0 0.011 15.7 0.0 1.5 1 0 0 1 1 1 1 NACHT domain AAA_18 PF13238.6 ELR10900.1 - 0.0073 16.9 0.0 0.017 15.6 0.0 1.7 1 0 0 1 1 1 1 AAA domain NTPase_1 PF03266.15 ELR10900.1 - 0.008 16.1 0.2 0.077 12.9 0.1 2.2 2 0 0 2 2 2 1 NTPase AAA_22 PF13401.6 ELR10900.1 - 0.0082 16.4 0.1 0.019 15.2 0.1 1.7 1 1 0 1 1 1 1 AAA domain cobW PF02492.19 ELR10900.1 - 0.01 15.4 0.4 0.018 14.6 0.4 1.4 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA_29 PF13555.6 ELR10900.1 - 0.011 15.4 0.0 0.028 14.1 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain MMR_HSR1 PF01926.23 ELR10900.1 - 0.016 15.2 0.1 0.037 14.1 0.1 1.6 1 0 0 1 1 1 0 50S ribosome-binding GTPase SRP54 PF00448.22 ELR10900.1 - 0.019 14.6 0.3 0.039 13.6 0.3 1.5 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain AAA PF00004.29 ELR10900.1 - 0.023 15.1 0.3 0.094 13.1 0.3 2.0 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) dNK PF01712.19 ELR10900.1 - 0.027 14.3 0.0 0.049 13.5 0.0 1.4 1 0 0 1 1 1 0 Deoxynucleoside kinase ATPase_2 PF01637.18 ELR10900.1 - 0.027 14.4 0.0 0.042 13.8 0.0 1.3 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_33 PF13671.6 ELR10900.1 - 0.042 14.0 0.0 0.09 12.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain Rad17 PF03215.15 ELR10900.1 - 0.045 13.7 0.0 0.088 12.7 0.0 1.4 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_5 PF07728.14 ELR10900.1 - 0.047 13.7 0.0 0.2 11.7 0.0 2.1 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) SMC_N PF02463.19 ELR10900.1 - 0.053 12.9 0.0 0.87 9.0 0.0 2.1 1 1 0 1 1 1 0 RecF/RecN/SMC N terminal domain KAP_NTPase PF07693.14 ELR10900.1 - 0.066 12.4 0.0 0.1 11.8 0.0 1.3 1 0 0 1 1 1 0 KAP family P-loop domain TsaE PF02367.17 ELR10900.1 - 0.079 13.0 0.0 0.16 12.0 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE PRK PF00485.18 ELR10900.1 - 0.11 12.3 0.0 2.6 7.7 0.0 2.2 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family AAA_14 PF13173.6 ELR10900.1 - 0.11 12.6 0.0 0.35 10.9 0.1 1.8 2 0 0 2 2 1 0 AAA domain RNA_helicase PF00910.22 ELR10900.1 - 0.11 12.8 0.0 0.24 11.8 0.0 1.5 1 0 0 1 1 1 0 RNA helicase RuvB_N PF05496.12 ELR10900.1 - 0.13 12.0 0.0 0.24 11.1 0.0 1.3 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain ATP_bind_1 PF03029.17 ELR10900.1 - 0.16 11.7 0.1 0.28 10.9 0.1 1.4 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein AAA_19 PF13245.6 ELR10900.1 - 0.18 12.2 0.1 0.42 10.9 0.1 1.6 1 0 0 1 1 1 0 AAA domain ABC_ATPase PF09818.9 ELR10900.1 - 0.29 9.9 0.8 0.89 8.3 0.3 1.8 1 1 1 2 2 2 0 Predicted ATPase of the ABC class Prefoldin_2 PF01920.20 ELR10901.1 - 9.8e-23 80.1 0.5 1.2e-22 79.9 0.5 1.0 1 0 0 1 1 1 1 Prefoldin subunit Prefoldin PF02996.17 ELR10901.1 - 0.0059 16.5 0.3 0.17 11.8 0.0 2.1 1 1 1 2 2 2 1 Prefoldin subunit STAT_alpha PF01017.20 ELR10901.1 - 0.02 14.8 2.4 0.06 13.2 2.4 1.7 1 1 0 1 1 1 0 STAT protein, all-alpha domain Ten1_2 PF15490.6 ELR10901.1 - 0.059 13.1 0.1 0.14 11.9 0.0 1.6 2 0 0 2 2 2 0 Telomere-capping, CST complex subunit Ubiquitin_5 PF18037.1 ELR10901.1 - 0.088 13.2 0.9 0.33 11.3 0.2 1.9 2 0 0 2 2 2 0 Ubiquitin-like domain Syntaxin_2 PF14523.6 ELR10901.1 - 0.12 12.8 2.2 2.9 8.3 0.2 2.1 2 0 0 2 2 2 0 Syntaxin-like protein Spc24 PF08286.11 ELR10901.1 - 0.92 9.8 4.6 3.5 7.9 0.3 2.1 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 Kinesin PF00225.23 ELR10902.1 - 2.1e-94 316.2 0.0 5.5e-94 314.8 0.0 1.8 1 0 0 1 1 1 1 Kinesin motor domain PH PF00169.29 ELR10902.1 - 9.8e-23 80.7 1.3 1.4e-22 80.2 0.3 1.9 2 0 0 2 2 2 1 PH domain Microtub_bd PF16796.5 ELR10902.1 - 1.1e-22 80.6 0.0 1.1e-22 80.6 0.0 2.3 2 0 0 2 2 2 1 Microtubule binding PH_11 PF15413.6 ELR10902.1 - 0.0003 21.2 5.2 0.0088 16.5 5.2 3.0 1 1 0 1 1 1 1 Pleckstrin homology domain PH_8 PF15409.6 ELR10902.1 - 0.00051 20.3 0.1 0.0017 18.6 0.1 2.0 1 0 0 1 1 1 1 Pleckstrin homology domain PH_9 PF15410.6 ELR10902.1 - 0.0018 18.6 0.6 0.011 16.0 0.6 2.3 1 1 0 1 1 1 1 Pleckstrin homology domain Pkinase_Tyr PF07714.17 ELR10903.1 - 4.4e-125 416.2 0.0 8.7e-62 208.7 0.0 2.4 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 ELR10903.1 - 1.3e-108 362.4 0.0 2.8e-56 190.8 0.0 2.3 2 0 0 2 2 2 2 Protein kinase domain PBP_like_2 PF12849.7 ELR10903.1 - 1.7e-27 96.8 4.6 4.7e-14 52.7 0.1 2.4 2 0 0 2 2 2 2 PBP superfamily domain Guanylate_cyc PF00211.20 ELR10903.1 - 3.6e-13 49.5 0.0 7.5e-13 48.5 0.0 1.5 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain APH PF01636.23 ELR10903.1 - 1.1e-07 32.1 0.1 7.7e-05 22.7 0.0 2.7 2 0 0 2 2 2 2 Phosphotransferase enzyme family Haspin_kinase PF12330.8 ELR10903.1 - 8.8e-06 24.9 0.2 0.014 14.3 0.0 2.5 2 1 0 2 2 2 2 Haspin like kinase domain EGF_2 PF07974.13 ELR10903.1 - 0.00014 22.1 13.0 0.00027 21.2 13.0 1.5 1 0 0 1 1 1 1 EGF-like domain EGF_Tenascin PF18720.1 ELR10903.1 - 0.0027 17.7 10.8 0.0059 16.6 10.8 1.6 1 0 0 1 1 1 1 Tenascin EGF domain Kinase-like PF14531.6 ELR10903.1 - 0.0029 17.0 0.0 0.35 10.1 0.0 2.3 2 0 0 2 2 2 1 Kinase-like FTA2 PF13095.6 ELR10903.1 - 0.021 14.4 0.0 6.8 6.2 0.0 3.2 2 1 1 3 3 3 0 Kinetochore Sim4 complex subunit FTA2 Kdo PF06293.14 ELR10903.1 - 0.051 12.9 0.1 5.1 6.4 0.0 2.3 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family hEGF PF12661.7 ELR10903.1 - 3 8.6 10.3 0.3 11.8 5.5 2.0 2 0 0 2 2 2 0 Human growth factor-like EGF EGF PF00008.27 ELR10903.1 - 4.8 7.6 11.7 1.3 9.4 7.9 2.0 2 0 0 2 2 2 0 EGF-like domain I-EGF_1 PF18372.1 ELR10903.1 - 7.3 6.8 8.3 17 5.6 8.3 1.7 1 0 0 1 1 1 0 Integrin beta epidermal growth factor like domain 1 DUF1445 PF07286.12 ELR10904.1 - 7.2e-63 210.8 0.2 1e-62 210.3 0.2 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1445) DnaJ PF00226.31 ELR10905.1 - 5.2e-25 87.4 0.2 2e-24 85.5 0.2 2.1 1 0 0 1 1 1 1 DnaJ domain zf-C2H2_jaz PF12171.8 ELR10905.1 - 1.6e-08 34.6 11.4 2.2e-08 34.1 8.4 2.4 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-C2H2_4 PF13894.6 ELR10905.1 - 5.5e-07 29.9 2.2 0.052 14.4 0.3 2.8 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_2 PF12756.7 ELR10905.1 - 5.3e-06 26.7 9.4 0.011 16.0 0.3 3.5 4 0 0 4 4 4 2 C2H2 type zinc-finger (2 copies) zf-met PF12874.7 ELR10905.1 - 6.7e-05 23.1 7.4 0.00013 22.2 3.8 2.6 2 0 0 2 2 2 1 Zinc-finger of C2H2 type zf-C2H2 PF00096.26 ELR10905.1 - 0.0002 21.6 4.8 0.04 14.4 0.2 2.6 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_6 PF13912.6 ELR10905.1 - 0.034 14.2 6.0 1.3 9.1 2.2 2.7 2 0 0 2 2 2 0 C2H2-type zinc finger DUF2256 PF10013.9 ELR10905.1 - 0.045 13.9 0.9 2.1 8.5 0.3 2.5 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2256) zf-U1 PF06220.12 ELR10905.1 - 0.071 12.9 1.3 0.17 11.7 1.3 1.7 1 0 0 1 1 1 0 U1 zinc finger Clathrin PF00637.20 ELR10906.1 - 3.4e-17 62.7 0.3 8e-17 61.5 0.3 1.7 1 0 0 1 1 1 1 Region in Clathrin and VPS Vps39_2 PF10367.9 ELR10906.1 - 9.2e-05 22.9 0.0 0.00074 19.9 0.0 2.3 2 0 0 2 2 2 1 Vacuolar sorting protein 39 domain 2 WD40 PF00400.32 ELR10906.1 - 0.0034 18.2 0.0 0.015 16.1 0.0 2.2 1 0 0 1 1 1 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ELR10906.1 - 0.026 14.8 0.0 0.17 12.2 0.0 2.3 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain zf-C3H2C3 PF17122.5 ELR10906.1 - 0.027 14.5 1.4 0.063 13.3 0.3 2.1 2 0 0 2 2 2 0 Zinc-finger VHS PF00790.19 ELR10907.1 - 0.0022 17.8 0.0 0.014 15.3 0.0 2.1 1 1 0 1 1 1 1 VHS domain BAG6 PF12057.8 ELR10907.1 - 0.053 13.2 0.0 0.29 10.8 0.0 2.4 1 0 0 1 1 1 0 BCL2-associated athanogene 6 BUD22 PF09073.10 ELR10907.1 - 0.069 12.5 42.3 0.092 12.1 26.2 2.3 2 0 0 2 2 2 0 BUD22 BSP_II PF05432.11 ELR10907.1 - 6.5 6.4 41.0 1.5 8.5 23.4 2.4 2 0 0 2 2 2 0 Bone sialoprotein II (BSP-II) HATPase_c PF02518.26 ELR10908.1 - 1.9e-26 92.8 0.0 6.1e-26 91.1 0.0 1.9 1 1 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 ELR10908.1 - 2.3e-22 79.2 0.0 4.1e-22 78.4 0.0 1.4 1 0 0 1 1 1 1 Response regulator receiver domain HisKA PF00512.25 ELR10908.1 - 2.6e-16 59.4 0.4 8.3e-16 57.8 0.1 2.1 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain Mito_carr PF00153.27 ELR10909.1 - 9.4e-18 63.9 7.1 8.7e-11 41.6 0.2 4.5 3 2 0 3 3 3 3 Mitochondrial carrier protein DUF4396 PF14342.6 ELR10909.1 - 0.13 12.7 1.7 0.45 10.9 0.7 2.2 2 1 0 2 2 2 0 Domain of unknown function (DUF4396) Histone_H2A_C PF16211.5 ELR10909.1 - 0.19 11.5 0.0 31 4.4 0.0 2.5 2 0 0 2 2 2 0 C-terminus of histone H2A 2-Hacid_dh_C PF02826.19 ELR10910.1 - 6.3e-38 129.9 0.1 2.4e-36 124.7 0.1 2.1 1 1 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 ELR10910.1 - 9.9e-21 73.8 0.0 1.5e-20 73.3 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.15 ELR10910.1 - 0.0017 18.5 0.0 0.0034 17.6 0.0 1.5 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase F420_oxidored PF03807.17 ELR10910.1 - 0.11 13.1 0.1 0.46 11.1 0.0 2.2 3 0 0 3 3 3 0 NADP oxidoreductase coenzyme F420-dependent FoP_duplication PF13865.6 ELR10912.1 - 3.6e-17 62.7 35.4 6e-14 52.4 35.4 2.8 1 1 0 1 1 1 1 C-terminal duplication domain of Friend of PRMT1 Peptidase_C39_2 PF13529.6 ELR10913.1 - 0.0003 21.4 0.0 0.00034 21.2 0.0 1.1 1 0 0 1 1 1 1 Peptidase_C39 like family Peptidase_C70 PF12385.8 ELR10913.1 - 0.12 12.4 0.0 0.16 11.9 0.0 1.1 1 0 0 1 1 1 0 Papain-like cysteine protease AvrRpt2 PARP PF00644.20 ELR10914.1 - 9.1e-13 48.2 0.0 2.1e-12 47.0 0.0 1.6 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain ARTD15_N PF18084.1 ELR10914.1 - 6.7e-12 45.5 0.1 1.7e-11 44.2 0.1 1.6 1 0 0 1 1 1 1 ARTD15 N-terminal domain zf-UBR PF02207.20 ELR10914.1 - 3.1e-05 24.1 4.7 3.1e-05 24.1 4.7 2.0 3 0 0 3 3 3 1 Putative zinc finger in N-recognin (UBR box) UBA PF00627.31 ELR10914.1 - 0.0025 17.7 0.0 0.0056 16.6 0.0 1.6 1 0 0 1 1 1 1 UBA/TS-N domain DUF3572 PF12096.8 ELR10914.1 - 0.11 12.7 0.1 71 3.7 0.0 3.5 3 0 0 3 3 3 0 Protein of unknown function (DUF3572) sCache_like PF16736.5 ELR10914.1 - 0.18 11.9 0.6 0.34 11.0 0.6 1.4 1 0 0 1 1 1 0 Single Cache-like C2 PF00168.30 ELR10915.1 - 2.5e-17 63.0 0.0 6.1e-17 61.8 0.0 1.7 2 0 0 2 2 2 1 C2 domain zf-UBR PF02207.20 ELR10915.1 - 0.0097 16.1 1.8 0.017 15.3 1.8 1.3 1 0 0 1 1 1 1 Putative zinc finger in N-recognin (UBR box) DUF2967 PF11179.8 ELR10915.1 - 0.043 11.9 1.5 0.069 11.3 1.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2967) MFAP1 PF06991.11 ELR10915.1 - 0.45 10.3 20.6 0.77 9.6 20.6 1.3 1 0 0 1 1 1 0 Microfibril-associated/Pre-mRNA processing TFIIF_alpha PF05793.12 ELR10915.1 - 1.7 7.1 25.4 2.6 6.6 25.4 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Presenilin PF01080.17 ELR10915.1 - 3.4 6.3 4.9 4.8 5.8 4.9 1.1 1 0 0 1 1 1 0 Presenilin CDC45 PF02724.14 ELR10915.1 - 5.7 5.1 16.4 8.8 4.5 16.4 1.2 1 0 0 1 1 1 0 CDC45-like protein Metal_resist PF13801.6 ELR10915.1 - 5.9 7.1 12.3 16 5.7 12.3 1.7 1 0 0 1 1 1 0 Heavy-metal resistance Pkinase PF00069.25 ELR10916.1 - 7.3e-61 205.8 0.0 7.3e-61 205.8 0.0 1.6 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR10916.1 - 4.2e-29 101.6 0.1 2.3e-28 99.2 0.1 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ELR10916.1 - 0.00049 19.5 0.2 0.0016 17.8 0.1 2.0 2 1 0 2 2 2 1 Kinase-like Haspin_kinase PF12330.8 ELR10916.1 - 0.019 13.9 0.5 0.037 13.0 0.5 1.5 1 1 0 1 1 1 0 Haspin like kinase domain Pkinase PF00069.25 ELR10917.1 - 5e-55 186.7 0.0 8.7e-55 185.9 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain LRR_8 PF13855.6 ELR10917.1 - 1.8e-46 155.7 53.8 1.9e-09 37.1 0.4 8.6 4 4 5 9 9 9 9 Leucine rich repeat LRR_4 PF12799.7 ELR10917.1 - 2.1e-32 110.6 62.6 8.6e-07 29.2 0.1 10.6 3 2 6 12 12 12 11 Leucine Rich repeats (2 copies) Pkinase_Tyr PF07714.17 ELR10917.1 - 8.1e-25 87.6 0.0 1.4e-24 86.8 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ELR10917.1 - 0.0052 16.1 0.0 0.013 14.9 0.0 1.6 1 0 0 1 1 1 1 Kinase-like LRR_1 PF00560.33 ELR10917.1 - 0.039 14.5 43.0 15 6.6 0.3 14.4 15 2 0 15 15 15 0 Leucine Rich Repeat CDRT4 PF15213.6 ELR10917.1 - 0.22 12.1 5.6 0.11 13.1 1.5 2.4 2 0 0 2 2 2 0 CMT1A duplicated region transcript 4 protein NST1 PF13945.6 ELR10917.1 - 0.7 10.0 14.3 6.8 6.7 9.0 2.4 2 0 0 2 2 2 0 Salt tolerance down-regulator RR_TM4-6 PF06459.12 ELR10917.1 - 5.6 6.7 9.6 4.1 7.1 3.0 2.3 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 Lipase_3 PF01764.25 ELR10918.1 - 1.6e-11 44.2 0.0 2.7e-11 43.5 0.0 1.3 1 0 0 1 1 1 1 Lipase (class 3) NHL PF01436.21 ELR10918.1 - 0.043 13.9 0.1 0.98 9.6 0.0 2.8 2 0 0 2 2 2 0 NHL repeat DUF4394 PF14339.6 ELR10918.1 - 0.11 11.8 0.0 4 6.7 0.0 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4394) LRR_8 PF13855.6 ELR10919.1 - 2.5e-49 164.9 53.1 6.7e-11 41.8 0.3 8.4 3 3 6 9 9 9 9 Leucine rich repeat LRR_4 PF12799.7 ELR10919.1 - 4.4e-35 119.1 61.6 9.4e-07 29.1 0.1 9.8 3 2 8 12 12 12 11 Leucine Rich repeats (2 copies) SAM_1 PF00536.30 ELR10919.1 - 1.8e-11 44.3 0.1 5.4e-11 42.8 0.1 1.8 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 ELR10919.1 - 6e-07 29.5 0.1 6e-07 29.5 0.1 3.5 5 0 0 5 5 5 1 SAM domain (Sterile alpha motif) LRR_1 PF00560.33 ELR10919.1 - 0.0011 19.2 41.3 16 6.6 0.3 14.7 15 2 0 15 15 15 1 Leucine Rich Repeat IGR PF09597.10 ELR10919.1 - 0.017 15.2 0.3 5.5 7.2 0.0 3.0 2 0 0 2 2 2 0 IGR protein motif PH PF00169.29 ELR10920.1 - 1e-13 51.7 0.2 1.9e-13 50.8 0.2 1.5 1 0 0 1 1 1 1 PH domain CAF-1_p150 PF11600.8 ELR10920.1 - 0.0065 16.2 36.1 0.011 15.5 36.1 1.4 1 0 0 1 1 1 1 Chromatin assembly factor 1 complex p150 subunit, N-terminal PH_11 PF15413.6 ELR10920.1 - 0.027 14.9 6.3 0.028 14.8 2.6 2.8 2 1 0 2 2 2 0 Pleckstrin homology domain RR_TM4-6 PF06459.12 ELR10920.1 - 0.035 13.9 17.2 0.043 13.6 17.2 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 PA26 PF04636.13 ELR10920.1 - 0.28 10.0 6.3 0.34 9.8 6.3 1.1 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) SprA-related PF12118.8 ELR10920.1 - 0.6 9.2 18.2 0.72 8.9 18.2 1.1 1 0 0 1 1 1 0 SprA-related family PPP4R2 PF09184.11 ELR10920.1 - 0.84 9.2 19.2 1.1 8.8 19.2 1.1 1 0 0 1 1 1 0 PPP4R2 DDHD PF02862.17 ELR10920.1 - 1.3 9.1 7.7 2 8.5 7.7 1.5 1 0 0 1 1 1 0 DDHD domain AAA_11 PF13086.6 ELR10920.1 - 1.7 8.3 12.6 2.1 8.1 12.6 1.2 1 0 0 1 1 1 0 AAA domain eIF-3_zeta PF05091.12 ELR10920.1 - 1.8 7.4 15.6 2.3 7.1 15.6 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) CENP-N PF05238.13 ELR10920.1 - 2.8 7.1 15.1 3.6 6.8 15.1 1.2 1 0 0 1 1 1 0 Kinetochore protein CHL4 like Neur_chan_memb PF02932.16 ELR10920.1 - 9.8 6.2 6.0 11 6.0 6.0 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region CBS PF00571.28 ELR10921.1 - 7.2e-24 84.0 3.3 1.8e-06 28.3 0.0 4.2 4 0 0 4 4 4 4 CBS domain RNase_H2_suC PF08615.11 ELR10921.1 - 0.011 15.9 0.7 4.7 7.4 0.1 2.3 2 0 0 2 2 2 0 Ribonuclease H2 non-catalytic subunit (Ylr154p-like) DNApol_Exo PF18136.1 ELR10921.1 - 0.012 14.8 3.3 0.071 12.2 1.8 2.1 1 1 1 2 2 2 0 DNA mitochondrial polymerase exonuclease domain HA2 PF04408.23 ELR10921.1 - 0.034 14.4 0.6 0.034 14.4 0.6 2.8 3 0 0 3 3 3 0 Helicase associated domain (HA2) AIF_C PF14721.6 ELR10921.1 - 0.1 12.9 4.4 7.2 7.0 1.4 2.4 2 0 0 2 2 2 0 Apoptosis-inducing factor, mitochondrion-associated, C-term DUF5523 PF17661.1 ELR10921.1 - 0.16 11.6 11.5 0.038 13.7 3.5 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5523) Eapp_C PF10238.9 ELR10921.1 - 0.36 10.9 4.0 0.69 10.0 0.3 2.3 2 0 0 2 2 2 0 E2F-associated phosphoprotein FAM176 PF14851.6 ELR10921.1 - 2.4 7.8 8.0 0.33 10.6 1.7 2.2 2 0 0 2 2 2 0 FAM176 family CPSF100_C PF13299.6 ELR10921.1 - 4.6 7.4 10.4 1 9.5 0.7 2.6 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal STAG PF08514.11 ELR10921.1 - 6.8 6.6 6.3 1.4e+02 2.4 0.0 3.3 3 0 0 3 3 3 0 STAG domain Kazal_1 PF00050.21 ELR10922.1 - 1.9e-31 107.8 51.1 8.1e-08 32.2 1.2 7.1 5 1 1 6 6 6 5 Kazal-type serine protease inhibitor domain Kazal_2 PF07648.15 ELR10922.1 - 6.6e-14 51.8 67.1 0.00037 20.6 2.7 8.3 9 1 0 9 9 9 5 Kazal-type serine protease inhibitor domain Lectin_leg-like PF03388.13 ELR10923.1 - 8.5e-45 152.9 0.1 4.4e-43 147.3 0.1 2.2 1 1 0 1 1 1 1 Legume-like lectin family Med21 PF11221.8 ELR10923.1 - 2.7e-24 86.1 0.0 2.7e-24 86.1 0.0 3.1 2 1 0 2 2 1 1 Subunit 21 of Mediator complex Bact_lectin PF18483.1 ELR10923.1 - 1.1e-06 28.8 0.2 2.9e-06 27.5 0.0 1.7 2 0 0 2 2 2 1 Bacterial lectin Med9 PF07544.13 ELR10923.1 - 0.00019 21.4 0.9 0.00019 21.4 0.9 2.8 2 1 0 2 2 1 1 RNA polymerase II transcription mediator complex subunit 9 Spore_YhcN_YlaJ PF09580.10 ELR10923.1 - 0.0055 16.8 2.2 0.0091 16.1 0.1 2.3 2 0 0 2 2 2 1 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) DUF4407 PF14362.6 ELR10923.1 - 0.095 12.0 9.2 0.018 14.4 2.6 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) DUF1387 PF07139.11 ELR10923.1 - 0.27 10.9 6.0 0.038 13.7 1.9 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1387) SesA PF17107.5 ELR10923.1 - 0.33 11.1 8.6 0.74 10.0 0.3 2.9 2 1 1 3 3 3 0 N-terminal domain on NACHT_NTPase and P-loop NTPases Peroxin-13_N PF04088.13 ELR10923.1 - 0.37 11.1 2.0 0.9 9.8 0.0 2.3 2 0 0 2 2 2 0 Peroxin 13, N-terminal region PilP PF04351.13 ELR10923.1 - 0.93 9.4 9.6 2.8 7.9 9.6 1.8 1 0 0 1 1 1 0 Pilus assembly protein, PilP DUF2120 PF09893.9 ELR10923.1 - 1.1 9.4 3.0 17 5.5 0.7 2.5 1 1 1 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2120) IL2 PF00715.17 ELR10923.1 - 1.8 8.5 6.5 0.46 10.4 2.7 2.0 2 0 0 2 2 2 0 Interleukin 2 AIP3 PF03915.13 ELR10923.1 - 2.4 7.2 14.3 0.14 11.2 7.6 2.1 2 0 0 2 2 2 0 Actin interacting protein 3 DUF1003 PF06210.11 ELR10923.1 - 5.1 7.3 5.5 27 4.9 5.5 2.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1003) GLTP PF08718.11 ELR10923.1 - 5.4 7.3 7.6 11 6.3 0.8 2.4 2 1 0 2 2 2 0 Glycolipid transfer protein (GLTP) DUF948 PF06103.11 ELR10923.1 - 7.3 6.9 14.3 7.4 6.9 2.1 4.3 3 1 1 4 4 4 0 Bacterial protein of unknown function (DUF948) DPM3 PF08285.11 ELR10924.1 - 5e-16 58.7 0.1 5.3e-16 58.6 0.1 1.0 1 0 0 1 1 1 1 Dolichol-phosphate mannosyltransferase subunit 3 (DPM3) A_deaminase PF00962.22 ELR10925.1 - 1.2e-56 192.5 0.0 2.2e-30 106.2 0.0 2.0 1 1 1 2 2 2 2 Adenosine/AMP deaminase EF-hand_8 PF13833.6 ELR10926.1 - 0.064 13.1 0.0 3.6 7.5 0.0 2.5 2 0 0 2 2 2 0 EF-hand domain pair Insulin_TMD PF17870.1 ELR10926.1 - 0.14 12.3 0.7 0.6 10.2 0.7 2.1 1 0 0 1 1 1 0 Insulin receptor trans-membrane segment Arrestin_C PF02752.22 ELR10927.1 - 4.5e-06 27.2 0.1 8.3e-06 26.3 0.1 1.4 1 0 0 1 1 1 1 Arrestin (or S-antigen), C-terminal domain AUDH_Cupin PF18637.1 ELR10927.1 - 0.00038 20.5 0.2 0.51 10.3 0.0 2.2 2 0 0 2 2 2 2 Aldos-2-ulose dehydratase/isomerase (AUDH) Cupin domain UPF0086 PF01868.16 ELR10927.1 - 0.021 14.7 0.2 0.049 13.6 0.2 1.7 1 1 0 1 1 1 0 Domain of unknown function UPF0086 HyaE PF07449.11 ELR10927.1 - 0.19 11.7 0.0 0.45 10.5 0.0 1.7 1 1 0 1 1 1 0 Hydrogenase-1 expression protein HyaE ThiF PF00899.21 ELR10928.1 - 8.4e-101 336.4 0.0 1.9e-72 243.6 0.0 2.8 2 1 0 2 2 2 2 ThiF family UBA_e1_thiolCys PF10585.9 ELR10928.1 - 1e-82 277.9 0.9 1.2e-82 277.7 0.1 1.6 2 0 0 2 2 2 1 Ubiquitin-activating enzyme active site E1_FCCH PF16190.5 ELR10928.1 - 1.2e-29 102.3 0.3 4e-29 100.6 0.3 2.0 2 0 0 2 2 2 1 Ubiquitin-activating enzyme E1 FCCH domain E1_4HB PF16191.5 ELR10928.1 - 2e-23 82.4 0.1 5e-23 81.1 0.1 1.8 1 0 0 1 1 1 1 Ubiquitin-activating enzyme E1 four-helix bundle E1_UFD PF09358.10 ELR10928.1 - 3e-18 66.3 0.0 6.8e-18 65.2 0.0 1.7 1 0 0 1 1 1 1 Ubiquitin fold domain DUF4792 PF16040.5 ELR10928.1 - 0.16 11.9 0.0 0.4 10.6 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4792) UPF0203 PF05254.12 ELR10930.1 - 1.1e-15 57.7 1.5 1.3e-15 57.4 1.5 1.1 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0203) COX17 PF05051.13 ELR10930.1 - 0.0066 16.8 1.2 0.014 15.8 1.2 1.5 1 1 0 1 1 1 1 Cytochrome C oxidase copper chaperone (COX17) Mesd PF10185.9 ELR10930.1 - 0.018 15.0 0.2 0.12 12.3 0.0 2.0 2 0 0 2 2 2 0 Chaperone for wingless signalling and trafficking of LDL receptor PCMT PF01135.19 ELR10931.1 - 1.6e-62 211.0 0.0 2.2e-62 210.5 0.0 1.1 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_31 PF13847.6 ELR10931.1 - 4e-10 39.7 0.0 7.1e-10 38.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ELR10931.1 - 3.9e-08 33.9 0.0 1.1e-07 32.5 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ELR10931.1 - 7.4e-07 29.7 0.0 2.1e-06 28.3 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_3 PF01596.17 ELR10931.1 - 5.4e-06 25.7 0.0 8.5e-06 25.1 0.0 1.2 1 0 0 1 1 1 1 O-methyltransferase Methyltransf_18 PF12847.7 ELR10931.1 - 6.5e-06 26.2 0.0 1.2e-05 25.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain GCD14 PF08704.10 ELR10931.1 - 5.3e-05 23.0 0.0 8.3e-05 22.4 0.0 1.2 1 0 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit Ubie_methyltran PF01209.18 ELR10931.1 - 0.0003 20.2 0.0 0.00048 19.5 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family MTS PF05175.14 ELR10931.1 - 0.00058 19.5 0.0 0.0011 18.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain Fibrillarin PF01269.17 ELR10931.1 - 0.00079 18.6 0.0 0.0014 17.8 0.0 1.3 1 0 0 1 1 1 1 Fibrillarin Methyltransf_24 PF13578.6 ELR10931.1 - 0.0012 19.8 0.0 0.005 17.8 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain TrmK PF04816.12 ELR10931.1 - 0.0015 18.1 0.0 0.0023 17.5 0.0 1.2 1 0 0 1 1 1 1 tRNA (adenine(22)-N(1))-methyltransferase Methyltransf_32 PF13679.6 ELR10931.1 - 0.0021 18.1 0.0 0.0043 17.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 ELR10931.1 - 0.003 17.0 0.0 0.0046 16.4 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_23 PF13489.6 ELR10931.1 - 0.0051 16.7 0.0 0.014 15.3 0.0 1.7 2 0 0 2 2 1 1 Methyltransferase domain Methyltr_RsmB-F PF01189.17 ELR10931.1 - 0.025 14.2 0.0 0.15 11.7 0.0 2.0 1 1 1 2 2 2 0 16S rRNA methyltransferase RsmB/F FtsJ PF01728.19 ELR10931.1 - 0.028 14.5 0.0 0.093 12.8 0.0 1.8 1 1 0 1 1 1 0 FtsJ-like methyltransferase Methyltransf_12 PF08242.12 ELR10931.1 - 0.04 14.6 0.0 0.096 13.4 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_16 PF10294.9 ELR10931.1 - 0.058 13.1 0.0 0.095 12.4 0.0 1.3 1 0 0 1 1 1 0 Lysine methyltransferase DUF21 PF01595.20 ELR10932.1 - 4e-26 91.8 5.1 7.7e-26 90.9 5.1 1.4 1 0 0 1 1 1 1 Cyclin M transmembrane N-terminal domain CBS PF00571.28 ELR10932.1 - 6.1e-07 29.8 0.6 0.0043 17.5 0.2 3.5 3 0 0 3 3 3 2 CBS domain GSDH PF07995.11 ELR10933.1 - 1.5e-11 44.2 0.0 7.1e-06 25.6 0.0 2.5 2 0 0 2 2 2 2 Glucose / Sorbosone dehydrogenase Ank_4 PF13637.6 ELR10934.1 - 7.7e-24 83.8 0.1 4.8e-16 58.9 0.2 3.6 1 1 3 4 4 4 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 ELR10934.1 - 1.6e-21 76.7 1.9 5.4e-16 58.9 0.2 2.3 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.30 ELR10934.1 - 1.9e-20 72.3 3.0 5.4e-07 29.8 0.1 4.5 4 0 0 4 4 4 4 Ankyrin repeat Ank_3 PF13606.6 ELR10934.1 - 1.5e-18 64.9 0.2 1.8e-07 30.9 0.0 4.4 4 0 0 4 4 4 3 Ankyrin repeat Ank_5 PF13857.6 ELR10934.1 - 1.2e-16 60.5 3.9 4.6e-10 39.5 0.9 4.2 2 2 2 4 4 4 4 Ankyrin repeats (many copies) BSP_II PF05432.11 ELR10934.1 - 0.0069 16.1 7.2 0.014 15.1 7.2 1.4 1 0 0 1 1 1 1 Bone sialoprotein II (BSP-II) FAM176 PF14851.6 ELR10934.1 - 0.051 13.2 4.0 0.15 11.7 4.0 1.8 1 0 0 1 1 1 0 FAM176 family SURF2 PF05477.11 ELR10934.1 - 0.1 12.3 5.3 0.22 11.2 5.3 1.5 1 1 0 1 1 1 0 Surfeit locus protein 2 (SURF2) NOA36 PF06524.12 ELR10934.1 - 0.46 9.7 5.8 0.81 8.9 5.8 1.3 1 0 0 1 1 1 0 NOA36 protein SR-25 PF10500.9 ELR10934.1 - 0.79 9.3 20.4 3.3 7.2 8.6 3.1 3 0 0 3 3 3 0 Nuclear RNA-splicing-associated protein Rsc14 PF08586.10 ELR10934.1 - 2 9.3 4.8 40 5.1 0.0 2.6 2 0 0 2 2 2 0 RSC complex, Rsc14/Ldb7 subunit Pkinase PF00069.25 ELR10935.1 - 3.9e-42 144.4 0.3 1.8e-41 142.2 0.3 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR10935.1 - 4.9e-27 94.9 1.4 2.8e-26 92.4 1.4 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase PBD PF00786.28 ELR10935.1 - 4.2e-16 59.0 0.6 4.3e-15 55.8 0.2 2.8 2 0 0 2 2 2 1 P21-Rho-binding domain MAS20 PF02064.15 ELR10935.1 - 0.021 14.9 2.8 0.042 14.0 2.8 1.5 1 0 0 1 1 1 0 MAS20 protein import receptor ZapB PF06005.12 ELR10935.1 - 1.3 9.5 7.5 3.5 8.1 7.5 1.7 1 0 0 1 1 1 0 Cell division protein ZapB RVT_1 PF00078.27 ELR10936.1 - 3.6e-42 144.4 0.0 5.8e-42 143.7 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RNase_H PF00075.24 ELR10936.1 - 2e-15 57.2 0.6 2.1e-14 53.9 0.0 2.6 3 0 0 3 3 3 1 RNase H Transglut_core2 PF13369.6 ELR10937.1 - 2.8e-35 121.2 0.0 4.4e-35 120.5 0.0 1.2 1 0 0 1 1 1 1 Transglutaminase-like superfamily Transglut_core PF01841.19 ELR10937.1 - 0.024 15.1 0.0 0.048 14.1 0.0 1.4 1 0 0 1 1 1 0 Transglutaminase-like superfamily CDC45 PF02724.14 ELR10937.1 - 0.035 12.4 3.6 0.043 12.1 3.6 1.1 1 0 0 1 1 1 0 CDC45-like protein SR-25 PF10500.9 ELR10937.1 - 0.069 12.8 8.4 0.1 12.2 8.4 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein BRCT_assoc PF12820.7 ELR10937.1 - 0.13 12.1 1.3 0.22 11.3 1.3 1.3 1 0 0 1 1 1 0 Serine-rich domain associated with BRCT RasGAP PF00616.19 ELR10938.1 - 9e-18 64.7 0.0 1.4e-17 64.1 0.0 1.3 1 0 0 1 1 1 1 GTPase-activator protein for Ras-like GTPase Laminin_G_3 PF13385.6 ELR10938.1 - 4.8e-14 52.8 0.6 1.6e-13 51.1 0.6 2.0 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Herpes_gE PF02480.16 ELR10938.1 - 0.018 13.8 1.4 0.027 13.2 0.0 1.8 2 0 0 2 2 2 0 Alphaherpesvirus glycoprotein E Gly-zipper_Omp PF13488.6 ELR10938.1 - 9 6.4 13.6 25 5.0 13.6 1.7 1 0 0 1 1 1 0 Glycine zipper PmbA_TldD PF01523.16 ELR10939.1 - 0.24 11.2 2.4 12 5.6 0.0 3.5 3 2 1 4 4 4 0 Putative modulator of DNA gyrase Cupin_8 PF13621.6 ELR10940.1 - 2.2e-44 152.1 0.0 3.8e-44 151.3 0.0 1.3 1 0 0 1 1 1 1 Cupin-like domain Cupin_4 PF08007.12 ELR10940.1 - 2.7e-10 40.2 0.1 6e-10 39.1 0.1 1.5 1 0 0 1 1 1 1 Cupin superfamily protein Cupin_2 PF07883.11 ELR10940.1 - 0.017 14.8 0.0 0.049 13.3 0.0 1.7 1 0 0 1 1 1 0 Cupin domain JmjC PF02373.22 ELR10940.1 - 0.086 13.3 0.0 0.27 11.6 0.0 1.9 1 1 0 1 1 1 0 JmjC domain, hydroxylase PPR_2 PF13041.6 ELR10941.1 - 1.7e-23 82.5 0.0 0.00061 19.9 0.0 7.5 8 1 1 9 9 9 5 PPR repeat family PPR_long PF17177.4 ELR10941.1 - 7.5e-16 58.1 0.0 4.5e-07 29.4 0.0 4.2 2 2 2 4 4 4 3 Pentacotripeptide-repeat region of PRORP PPR_3 PF13812.6 ELR10941.1 - 2.7e-15 56.2 0.0 0.0015 18.6 0.0 5.9 5 1 1 6 6 6 5 Pentatricopeptide repeat domain PPR PF01535.20 ELR10941.1 - 5.2e-08 32.6 6.0 1.2 9.6 0.0 7.3 7 1 1 8 8 8 2 PPR repeat PPR_1 PF12854.7 ELR10941.1 - 0.0025 17.5 0.0 8.5 6.2 0.0 5.6 7 0 0 7 7 7 1 PPR repeat DUF4303 PF14136.6 ELR10941.1 - 0.0029 17.4 0.1 0.0053 16.5 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4303) ATP13 PF12921.7 ELR10941.1 - 0.22 11.4 0.0 0.77 9.6 0.0 1.8 2 0 0 2 2 2 0 Mitochondrial ATPase expression DJ-1_PfpI PF01965.24 ELR10942.1 - 1.1e-35 122.8 0.1 2.7e-35 121.6 0.1 1.5 1 1 0 1 1 1 1 DJ-1/PfpI family Ras PF00071.22 ELR10944.1 - 1.1e-37 129.1 1.1 9.8e-37 126.0 1.1 1.9 1 1 0 1 1 1 1 Ras family Roc PF08477.13 ELR10944.1 - 8.5e-14 51.8 0.3 2.4e-12 47.1 0.3 2.1 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR10944.1 - 1.9e-10 40.5 0.0 2.7e-10 40.0 0.0 1.3 1 1 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 ELR10944.1 - 1.4e-06 27.9 0.1 2.8e-05 23.8 0.0 2.1 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 ELR10944.1 - 0.00018 21.5 0.0 0.12 12.3 0.0 2.1 2 0 0 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 ELR10944.1 - 0.00046 20.3 0.1 0.003 17.6 0.1 2.0 1 1 0 1 1 1 1 50S ribosome-binding GTPase ATP_bind_1 PF03029.17 ELR10944.1 - 0.00077 19.3 0.7 0.12 12.1 0.0 2.1 1 1 1 2 2 2 1 Conserved hypothetical ATP binding protein G-alpha PF00503.20 ELR10944.1 - 0.0051 16.0 0.0 0.11 11.6 0.0 2.0 1 1 0 2 2 2 1 G-protein alpha subunit cobW PF02492.19 ELR10944.1 - 0.0068 16.0 0.1 1.9 8.1 0.0 2.2 2 0 0 2 2 2 2 CobW/HypB/UreG, nucleotide-binding domain AAA_33 PF13671.6 ELR10944.1 - 0.0074 16.5 0.3 0.018 15.2 0.3 1.8 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 ELR10944.1 - 0.0096 16.3 0.5 0.016 15.6 0.5 1.6 1 1 0 1 1 1 1 AAA ATPase domain AAA_25 PF13481.6 ELR10944.1 - 0.014 14.9 0.4 0.076 12.6 0.1 2.0 2 1 0 2 2 2 0 AAA domain Gtr1_RagA PF04670.12 ELR10944.1 - 0.018 14.4 0.0 0.033 13.6 0.0 1.5 1 1 0 1 1 1 0 Gtr1/RagA G protein conserved region ATP-synt_ab PF00006.25 ELR10944.1 - 0.044 13.4 0.3 0.5 10.0 0.3 2.2 1 1 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain AAA_14 PF13173.6 ELR10944.1 - 0.056 13.5 0.0 0.088 12.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain NTPase_1 PF03266.15 ELR10944.1 - 0.084 12.8 0.0 0.13 12.2 0.0 1.3 1 0 0 1 1 1 0 NTPase DAP3 PF10236.9 ELR10944.1 - 0.09 11.9 0.3 0.12 11.5 0.3 1.2 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 NB-ARC PF00931.22 ELR10944.1 - 0.091 11.9 0.3 0.16 11.2 0.3 1.4 1 0 0 1 1 1 0 NB-ARC domain CbiA PF01656.23 ELR10944.1 - 0.098 12.7 0.1 0.21 11.7 0.1 1.5 1 0 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain Septin PF00735.18 ELR10944.1 - 0.21 10.8 0.0 0.28 10.4 0.0 1.2 1 0 0 1 1 1 0 Septin AAA_24 PF13479.6 ELR10944.1 - 0.21 11.3 0.0 0.27 11.0 0.0 1.3 1 0 0 1 1 1 0 AAA domain FtsK_SpoIIIE PF01580.18 ELR10944.1 - 0.96 8.7 3.5 0.64 9.3 0.2 2.1 3 0 0 3 3 3 0 FtsK/SpoIIIE family Ras PF00071.22 ELR10945.1 - 7.9e-43 145.9 0.0 9.1e-43 145.7 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR10945.1 - 7.8e-13 48.7 0.0 1e-12 48.3 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR10945.1 - 1.2e-09 37.8 0.0 1.3e-09 37.7 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 ELR10945.1 - 0.00018 21.5 0.1 0.49 10.3 0.1 2.2 1 1 0 2 2 2 2 RsgA GTPase GTP_EFTU PF00009.27 ELR10945.1 - 0.0011 18.6 0.0 0.0017 17.9 0.0 1.4 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 ELR10945.1 - 0.004 17.2 0.0 0.0065 16.5 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_16 PF13191.6 ELR10945.1 - 0.024 15.0 0.2 0.052 13.9 0.2 1.7 1 1 0 1 1 1 0 AAA ATPase domain AAA_33 PF13671.6 ELR10945.1 - 0.024 14.8 0.5 0.094 12.9 0.5 1.8 1 1 0 1 1 1 0 AAA domain ATP-synt_ab PF00006.25 ELR10945.1 - 0.048 13.3 0.1 0.27 10.9 0.1 1.9 1 1 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain MMR_HSR1_Xtn PF16897.5 ELR10945.1 - 0.11 12.5 0.0 0.2 11.7 0.0 1.5 1 1 0 1 1 1 0 C-terminal region of MMR_HSR1 domain AAA_22 PF13401.6 ELR10945.1 - 0.15 12.3 0.0 0.27 11.5 0.0 1.7 1 1 0 1 1 1 0 AAA domain cobW PF02492.19 ELR10945.1 - 0.15 11.6 0.8 2.6 7.6 0.1 2.2 1 1 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_14 PF13173.6 ELR10945.1 - 0.15 12.1 0.0 0.23 11.5 0.0 1.5 1 1 0 1 1 1 0 AAA domain ATP_bind_1 PF03029.17 ELR10945.1 - 0.21 11.4 0.9 2.8 7.7 0.0 2.1 1 1 1 2 2 2 0 Conserved hypothetical ATP binding protein NB-ARC PF00931.22 ELR10945.1 - 0.22 10.7 0.0 0.28 10.3 0.0 1.2 1 0 0 1 1 1 0 NB-ARC domain NHL PF01436.21 ELR10946.1 - 4.1e-24 83.3 10.8 2.9e-06 27.0 0.1 7.7 8 1 0 8 8 8 5 NHL repeat Thioredoxin_8 PF13905.6 ELR10946.1 - 9e-11 42.0 0.0 2.4e-10 40.6 0.0 1.7 1 0 0 1 1 1 1 Thioredoxin-like Redoxin PF08534.10 ELR10946.1 - 4.4e-07 29.7 0.0 1.4e-06 28.1 0.0 1.9 1 0 0 1 1 1 1 Redoxin AhpC-TSA PF00578.21 ELR10946.1 - 4e-05 23.5 0.0 9.2e-05 22.4 0.0 1.6 1 0 0 1 1 1 1 AhpC/TSA family Thioredoxin PF00085.20 ELR10946.1 - 0.00061 19.7 0.1 0.0014 18.6 0.1 1.5 1 0 0 1 1 1 1 Thioredoxin SGL PF08450.12 ELR10946.1 - 0.0097 15.5 0.0 0.3 10.6 0.0 2.9 3 0 0 3 3 3 1 SMP-30/Gluconolactonase/LRE-like region DTHCT PF08070.11 ELR10946.1 - 9.8 7.0 10.4 0.27 12.0 1.1 2.8 3 0 0 3 3 3 0 DTHCT (NUC029) region Peptidase_S74 PF13884.6 ELR10947.1 - 3.5e-08 33.7 0.0 1.7e-07 31.4 0.0 2.3 2 0 0 2 2 2 1 Chaperone of endosialidase Fascin PF06268.13 ELR10947.1 - 0.0014 18.9 0.0 0.0033 17.6 0.0 1.6 1 0 0 1 1 1 1 Fascin domain DDHD PF02862.17 ELR10947.1 - 0.26 11.4 5.1 0.55 10.4 1.1 2.7 2 0 0 2 2 2 0 DDHD domain EMP24_GP25L PF01105.24 ELR10947.1 - 0.33 10.9 1.4 0.93 9.4 1.4 1.7 1 0 0 1 1 1 0 emp24/gp25L/p24 family/GOLD YL1 PF05764.13 ELR10947.1 - 0.51 10.4 32.3 0.054 13.6 2.2 3.1 4 0 0 4 4 4 0 YL1 nuclear protein ABC2_membrane PF01061.24 ELR10948.1 - 8.4e-69 231.2 45.4 2.5e-37 128.4 18.6 3.3 2 1 1 3 3 3 3 ABC-2 type transporter ABC_tran PF00005.27 ELR10948.1 - 1.1e-39 136.1 0.0 4.2e-19 69.4 0.0 2.5 2 0 0 2 2 2 2 ABC transporter AAA_16 PF13191.6 ELR10948.1 - 7.1e-09 36.3 0.1 0.0032 17.9 0.0 2.9 3 0 0 3 3 3 2 AAA ATPase domain RsgA_GTPase PF03193.16 ELR10948.1 - 7.1e-08 32.5 0.2 0.001 19.0 0.0 2.4 2 0 0 2 2 2 2 RsgA GTPase AAA_29 PF13555.6 ELR10948.1 - 3.4e-07 29.9 1.2 0.0037 17.0 0.1 2.9 3 0 0 3 3 3 2 P-loop containing region of AAA domain AAA_22 PF13401.6 ELR10948.1 - 3.6e-07 30.5 0.1 0.0098 16.2 0.0 2.6 2 1 0 2 2 2 2 AAA domain AAA_25 PF13481.6 ELR10948.1 - 2e-06 27.5 0.1 0.051 13.2 0.0 2.7 3 0 0 3 3 3 2 AAA domain AAA_21 PF13304.6 ELR10948.1 - 3.9e-06 26.9 0.1 0.055 13.3 0.0 3.4 3 0 0 3 3 3 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_18 PF13238.6 ELR10948.1 - 1.4e-05 25.7 0.0 0.37 11.4 0.0 2.7 2 0 0 2 2 2 2 AAA domain AAA_33 PF13671.6 ELR10948.1 - 1.9e-05 24.8 0.4 0.068 13.3 0.0 2.7 2 0 0 2 2 2 2 AAA domain RNA_helicase PF00910.22 ELR10948.1 - 0.00018 21.9 0.0 0.54 10.7 0.0 2.9 2 0 0 2 2 2 2 RNA helicase NACHT PF05729.12 ELR10948.1 - 0.00025 21.0 0.8 0.052 13.5 0.0 2.4 2 0 0 2 2 2 1 NACHT domain AAA PF00004.29 ELR10948.1 - 0.0004 20.8 0.3 0.051 14.0 0.0 3.2 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_28 PF13521.6 ELR10948.1 - 0.00046 20.5 2.1 0.65 10.2 0.1 3.0 3 0 0 3 3 3 2 AAA domain Rad17 PF03215.15 ELR10948.1 - 0.0038 17.2 0.0 1.4 8.8 0.0 2.3 2 0 0 2 2 2 1 Rad17 P-loop domain DUF815 PF05673.13 ELR10948.1 - 0.0038 16.4 0.3 1.5 8.0 0.0 2.2 2 0 0 2 2 2 2 Protein of unknown function (DUF815) AAA_30 PF13604.6 ELR10948.1 - 0.0047 16.7 0.2 4.3 7.0 0.2 2.5 2 0 0 2 2 2 2 AAA domain MMR_HSR1 PF01926.23 ELR10948.1 - 0.0055 16.8 0.3 1.6 8.9 0.1 2.5 2 0 0 2 2 2 1 50S ribosome-binding GTPase IstB_IS21 PF01695.17 ELR10948.1 - 0.0059 16.4 0.0 4.6 6.9 0.0 2.3 2 0 0 2 2 2 2 IstB-like ATP binding protein Zeta_toxin PF06414.12 ELR10948.1 - 0.0073 15.6 1.0 1.3 8.2 0.0 2.2 2 0 0 2 2 2 1 Zeta toxin TsaE PF02367.17 ELR10948.1 - 0.014 15.4 0.3 8.5 6.4 0.0 2.5 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Ploopntkinase3 PF18751.1 ELR10948.1 - 0.016 15.1 0.2 6.5 6.6 0.1 2.4 2 0 0 2 2 2 0 P-loop Nucleotide Kinase3 AAA_7 PF12775.7 ELR10948.1 - 0.019 14.5 0.1 1 8.8 0.0 2.3 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_5 PF07728.14 ELR10948.1 - 0.036 14.1 2.5 0.68 9.9 0.2 2.6 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) PDR_assoc PF08370.11 ELR10948.1 - 0.037 13.8 0.1 0.037 13.8 0.1 2.9 3 0 0 3 3 2 0 Plant PDR ABC transporter associated AAA_23 PF13476.6 ELR10948.1 - 0.056 14.0 0.4 8 6.9 0.0 2.8 3 0 0 3 3 2 0 AAA domain DUF87 PF01935.17 ELR10948.1 - 0.083 13.0 2.8 0.99 9.4 0.7 2.5 2 0 0 2 2 2 0 Helicase HerA, central domain AAA_14 PF13173.6 ELR10948.1 - 0.13 12.3 0.1 8.8 6.4 0.0 2.7 2 0 0 2 2 2 0 AAA domain Viral_helicase1 PF01443.18 ELR10948.1 - 0.13 11.9 0.4 0.56 9.9 0.0 2.0 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase PDR_CDR PF06422.12 ELR10948.1 - 3.6 7.6 4.8 15 5.6 0.0 3.5 4 0 0 4 4 3 0 CDR ABC transporter p450 PF00067.22 ELR10949.1 - 5e-77 259.6 0.0 6.7e-77 259.2 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 CNDH2_C PF16858.5 ELR10950.1 - 0.012 15.5 11.2 0.012 15.5 11.2 2.3 2 0 0 2 2 2 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term BUD22 PF09073.10 ELR10950.1 - 0.014 14.7 50.3 0.034 13.5 21.0 2.1 2 0 0 2 2 2 0 BUD22 TFIIA PF03153.13 ELR10950.1 - 0.036 14.1 27.6 0.054 13.5 6.8 2.2 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit BclA_C PF18573.1 ELR10950.1 - 0.096 12.6 0.0 0.17 11.8 0.0 1.3 1 0 0 1 1 1 0 BclA C-terminal domain zf-C5HC2 PF02928.16 ELR10950.1 - 0.16 12.4 1.4 0.31 11.4 0.1 2.1 2 0 0 2 2 2 0 C5HC2 zinc finger Cwf_Cwc_15 PF04889.12 ELR10950.1 - 0.65 9.7 51.5 0.012 15.4 18.4 2.3 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein AF-4 PF05110.13 ELR10950.1 - 9.8 4.1 36.9 0.47 8.5 16.6 2.0 2 0 0 2 2 2 0 AF-4 proto-oncoprotein Methyltransf_25 PF13649.6 ELR10951.1 - 7e-06 26.7 0.0 1.3e-05 25.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ELR10951.1 - 0.016 15.8 0.0 0.027 15.1 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_12 PF08242.12 ELR10951.1 - 0.032 15.0 0.0 0.057 14.2 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain FAP PF07174.11 ELR10952.1 - 8.6 5.7 23.6 17 4.7 23.6 1.4 1 0 0 1 1 1 0 Fibronectin-attachment protein (FAP) DUF2384 PF09722.10 ELR10956.1 - 0.044 13.8 0.0 0.095 12.8 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2384) SRI PF08236.11 ELR10957.1 - 2e-05 24.7 9.8 2e-05 24.7 9.8 2.6 2 1 0 2 2 1 1 SRI (Set2 Rpb1 interacting) domain RR_TM4-6 PF06459.12 ELR10957.1 - 0.0056 16.5 17.8 0.008 16.0 17.8 1.2 1 0 0 1 1 1 1 Ryanodine Receptor TM 4-6 RNA_pol_Rpc4 PF05132.14 ELR10957.1 - 0.016 15.6 7.5 0.037 14.4 7.5 1.6 1 0 0 1 1 1 0 RNA polymerase III RPC4 Hox9_act PF04617.13 ELR10957.1 - 0.019 15.8 5.0 0.019 15.8 5.0 1.8 2 0 0 2 2 2 0 Hox9 activation region Hamartin PF04388.12 ELR10957.1 - 0.089 11.4 7.6 0.1 11.2 7.6 1.0 1 0 0 1 1 1 0 Hamartin protein PTPRCAP PF15713.5 ELR10957.1 - 0.11 12.8 12.0 0.19 12.0 12.0 1.4 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated DOG1 PF14144.6 ELR10957.1 - 0.11 12.7 0.1 0.28 11.4 0.1 1.7 1 0 0 1 1 1 0 Seed dormancy control DDHD PF02862.17 ELR10957.1 - 0.13 12.4 2.4 0.16 12.1 2.4 1.3 1 0 0 1 1 1 0 DDHD domain SAPS PF04499.15 ELR10957.1 - 0.32 9.7 6.6 0.37 9.5 6.6 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Presenilin PF01080.17 ELR10957.1 - 0.35 9.6 11.3 0.41 9.4 11.3 1.1 1 0 0 1 1 1 0 Presenilin Macoilin PF09726.9 ELR10957.1 - 0.36 9.3 18.7 0.47 9.0 18.7 1.1 1 0 0 1 1 1 0 Macoilin family TFIIA PF03153.13 ELR10957.1 - 0.37 10.8 17.4 0.63 10.0 16.9 1.5 1 1 1 2 2 2 0 Transcription factor IIA, alpha/beta subunit CDC45 PF02724.14 ELR10957.1 - 0.62 8.3 18.9 0.8 7.9 18.9 1.1 1 0 0 1 1 1 0 CDC45-like protein VIR_N PF15912.5 ELR10957.1 - 0.76 9.3 12.3 1.1 8.7 12.3 1.2 1 0 0 1 1 1 0 Virilizer, N-terminal RRN3 PF05327.11 ELR10957.1 - 0.85 8.1 7.1 1 7.8 7.1 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 DUF913 PF06025.12 ELR10957.1 - 1.2 8.0 5.8 1.7 7.5 5.8 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Borrelia_P83 PF05262.11 ELR10957.1 - 1.5 7.2 19.2 1.8 6.9 19.2 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein Zip PF02535.22 ELR10957.1 - 1.6 7.9 5.8 1.8 7.7 5.8 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter AAA_11 PF13086.6 ELR10957.1 - 2.3 7.9 12.5 3.1 7.5 12.5 1.2 1 0 0 1 1 1 0 AAA domain Rxt3 PF08642.10 ELR10957.1 - 2.9 8.7 7.2 6.2 7.6 7.2 1.6 1 1 0 1 1 1 0 Histone deacetylation protein Rxt3 Endostatin PF06482.11 ELR10957.1 - 3.4 7.0 9.6 4.7 6.6 9.6 1.1 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin SID-1_RNA_chan PF13965.6 ELR10957.1 - 4.8 5.5 4.0 5.7 5.2 4.0 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 EOS1 PF12326.8 ELR10957.1 - 6.8 6.6 5.0 10 6.0 5.0 1.4 1 0 0 1 1 1 0 N-glycosylation protein NPR3 PF03666.13 ELR10957.1 - 7.3 5.3 13.1 9.5 4.9 13.1 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Connexin PF00029.19 ELR10957.1 - 8 6.1 10.7 12 5.6 10.7 1.4 1 0 0 1 1 1 0 Connexin Hid1 PF12722.7 ELR10957.1 - 8.8 4.3 10.8 10 4.1 10.8 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein PALP PF00291.25 ELR10959.1 - 2.7e-58 197.7 2.0 3.1e-58 197.5 2.0 1.0 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme CBS PF00571.28 ELR10960.1 - 7.8e-09 35.9 0.4 0.036 14.5 0.1 3.6 3 0 0 3 3 3 3 CBS domain PH PF00169.29 ELR10961.1 - 7.9e-17 61.7 0.4 8.7e-17 61.6 0.4 1.0 1 0 0 1 1 1 1 PH domain PH_3 PF14593.6 ELR10961.1 - 7.1e-07 29.3 0.2 8.1e-07 29.1 0.2 1.0 1 0 0 1 1 1 1 PH domain PH_8 PF15409.6 ELR10961.1 - 1.2e-06 28.7 0.3 1.3e-06 28.6 0.3 1.0 1 0 0 1 1 1 1 Pleckstrin homology domain PH_6 PF15406.6 ELR10961.1 - 8.9e-06 26.0 0.0 1e-05 25.8 0.0 1.0 1 0 0 1 1 1 1 Pleckstrin homology domain PH_11 PF15413.6 ELR10961.1 - 1.1e-05 25.8 3.9 0.0025 18.2 3.9 2.0 1 1 0 1 1 1 1 Pleckstrin homology domain PH_13 PF16652.5 ELR10961.1 - 0.00054 19.8 0.1 0.0007 19.4 0.1 1.1 1 0 0 1 1 1 1 Pleckstrin homology domain PH_9 PF15410.6 ELR10961.1 - 0.0094 16.3 0.4 1 9.7 0.4 2.1 1 1 0 1 1 1 1 Pleckstrin homology domain ToxN_toxin PF13958.6 ELR10961.1 - 0.078 13.2 0.0 0.085 13.1 0.0 1.0 1 0 0 1 1 1 0 Toxin ToxN, type III toxin-antitoxin system A2M_recep PF07677.14 ELR10961.1 - 0.088 13.5 0.0 0.12 13.1 0.0 1.2 1 0 0 1 1 1 0 A-macroglobulin receptor binding domain zf-RING_2 PF13639.6 ELR10962.1 - 3.5e-11 43.2 7.6 3.5e-11 43.2 7.6 1.8 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_3 PF13920.6 ELR10962.1 - 6e-09 35.6 5.3 1e-08 34.9 5.3 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 ELR10962.1 - 1.2e-08 34.6 2.2 2.2e-08 33.7 2.2 1.5 1 0 0 1 1 1 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 ELR10962.1 - 2.9e-08 33.4 8.6 6.1e-08 32.4 8.6 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 ELR10962.1 - 6.6e-08 32.7 5.0 1.4e-07 31.7 5.0 1.6 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_5 PF14634.6 ELR10962.1 - 1e-07 31.8 5.5 1.8e-07 31.0 5.5 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4 PF00097.25 ELR10962.1 - 2.5e-06 27.2 7.8 5.1e-06 26.3 7.8 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 ELR10962.1 - 1.6e-05 24.7 5.6 3e-05 23.8 5.6 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_UBOX PF13445.6 ELR10962.1 - 0.0002 21.3 5.7 0.00043 20.2 5.7 1.6 1 0 0 1 1 1 1 RING-type zinc-finger Zn_ribbon_17 PF17120.5 ELR10962.1 - 0.00031 20.3 4.9 0.00059 19.4 4.9 1.4 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type zf-ANAPC11 PF12861.7 ELR10962.1 - 0.0063 16.5 3.4 0.015 15.4 3.4 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger FANCL_C PF11793.8 ELR10962.1 - 0.016 15.4 11.6 0.061 13.5 6.5 2.8 2 1 0 2 2 2 0 FANCL C-terminal domain zf-RING_4 PF14570.6 ELR10962.1 - 0.04 13.7 5.3 0.087 12.6 5.3 1.6 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain RINGv PF12906.7 ELR10962.1 - 0.16 12.1 6.2 0.32 11.1 6.2 1.5 1 0 0 1 1 1 0 RING-variant domain zf-C3H2C3 PF17122.5 ELR10962.1 - 0.16 12.0 1.6 0.45 10.6 1.6 1.8 1 0 0 1 1 1 0 Zinc-finger zf-RING_9 PF13901.6 ELR10962.1 - 0.17 11.8 3.5 0.3 11.0 3.5 1.3 1 0 0 1 1 1 0 Putative zinc-RING and/or ribbon zf-RING-like PF08746.11 ELR10962.1 - 2.1 8.7 5.2 4.9 7.5 5.2 1.7 1 0 0 1 1 1 0 RING-like domain LMWPc PF01451.21 ELR10963.1 - 7.3e-23 81.5 0.0 8.5e-23 81.3 0.0 1.0 1 0 0 1 1 1 1 Low molecular weight phosphotyrosine protein phosphatase LPP20 PF02169.16 ELR10964.1 - 0.016 15.5 1.2 0.028 14.8 0.7 1.6 1 1 0 1 1 1 0 LPP20 lipoprotein Macoilin PF09726.9 ELR10964.1 - 0.032 12.8 9.3 0.033 12.8 9.3 1.1 1 0 0 1 1 1 0 Macoilin family DUF641 PF04859.12 ELR10964.1 - 0.44 10.9 17.6 2.4 8.5 4.4 2.2 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) DUF3458_C PF17432.2 ELR10964.1 - 0.59 9.5 9.0 0.8 9.0 9.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3458_C) ARM repeats Exonuc_VII_L PF02601.15 ELR10964.1 - 1.2 8.6 14.3 1.6 8.2 14.3 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF4094 PF13334.6 ELR10964.1 - 1.4 9.4 7.6 1.6 9.2 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4094) Striatin PF08232.12 ELR10964.1 - 1.7 9.2 19.1 7.1 7.2 7.4 2.3 1 1 1 2 2 2 0 Striatin family FadA PF09403.10 ELR10964.1 - 3.1 8.4 20.1 2.7 8.6 18.3 1.8 1 1 1 2 2 2 0 Adhesion protein FadA HGD-D PF06050.13 ELR10964.1 - 4.2 7.0 8.1 2.1 8.0 1.4 2.0 1 1 1 2 2 2 0 2-hydroxyglutaryl-CoA dehydratase, D-component UPF0242 PF06785.11 ELR10964.1 - 5.4 7.1 20.9 7.3 6.7 20.9 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus DUF572 PF04502.13 ELR10964.1 - 6.3 6.3 15.4 8 6.0 15.4 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) 7TMR-HDED PF07697.11 ELR10964.1 - 9.7 6.2 15.5 18 5.4 15.5 1.5 1 1 0 1 1 1 0 7TM-HD extracellular RhoGAP PF00620.27 ELR10965.1 - 4e-38 130.6 0.0 7.9e-38 129.7 0.0 1.4 1 0 0 1 1 1 1 RhoGAP domain DnaJ_CXXCXGXG PF00684.19 ELR10966.1 - 1.7e-09 37.9 39.3 4.2e-06 27.0 10.9 2.7 1 1 2 3 3 3 3 DnaJ central domain zinc-ribbons_6 PF07191.12 ELR10966.1 - 1.1 9.3 12.0 4.9 7.2 3.0 2.6 1 1 2 3 3 3 0 zinc-ribbons Anti-TRAP PF15777.5 ELR10966.1 - 1.6 8.8 35.3 1.5 8.9 1.8 4.7 1 1 1 3 3 3 0 Tryptophan RNA-binding attenuator protein inhibitory protein DUF2752 PF10825.8 ELR10966.1 - 7.4 6.7 13.1 15 5.8 1.6 3.3 2 1 1 3 3 3 0 Protein of unknown function (DUF2752) TackOD1 PF18551.1 ELR10966.1 - 8.8 6.0 14.7 0.57 9.8 0.9 3.0 1 1 0 2 2 2 0 Thaumarchaeal output domain 1 Fascin PF06268.13 ELR10967.1 - 1.2e-18 67.3 0.0 2.5e-10 40.6 0.0 2.2 1 1 1 2 2 2 2 Fascin domain FRG1 PF06229.12 ELR10967.1 - 2.9e-08 33.7 0.0 0.0061 16.3 0.0 2.4 1 1 1 2 2 2 2 FRG1-like domain DUF569 PF04601.13 ELR10967.1 - 0.0083 15.8 0.0 0.083 12.6 0.0 2.2 1 1 2 3 3 3 3 Domain of unknown function (DUF569) FGF PF00167.18 ELR10967.1 - 0.011 15.8 0.0 0.03 14.4 0.0 1.7 1 1 0 1 1 1 0 Fibroblast growth factor zf-MYND PF01753.18 ELR10969.1 - 2.3e-05 24.4 10.3 2.3e-05 24.4 10.3 3.6 3 1 0 3 3 3 1 MYND finger zf-C2H2_4 PF13894.6 ELR10969.1 - 0.0014 19.3 8.3 0.0098 16.7 0.5 3.7 3 0 0 3 3 3 1 C2H2-type zinc finger zf_C2H2_ZHX PF18387.1 ELR10969.1 - 0.0021 17.6 0.8 0.0076 15.9 0.1 2.2 2 0 0 2 2 2 1 Zinc-fingers and homeoboxes C2H2 finger domain zf-ACC PF17848.1 ELR10969.1 - 0.018 15.1 0.6 0.018 15.1 0.6 3.5 4 0 0 4 4 4 0 Acetyl-coA carboxylase zinc finger domain zf-C2H2 PF00096.26 ELR10969.1 - 0.027 14.9 1.4 0.027 14.9 1.4 4.0 4 1 0 4 4 4 0 Zinc finger, C2H2 type zf-C2H2_2 PF12756.7 ELR10969.1 - 0.031 14.6 0.1 0.031 14.6 0.1 1.9 2 0 0 2 2 2 0 C2H2 type zinc-finger (2 copies) zf_UBZ PF18439.1 ELR10969.1 - 3.6 7.3 7.5 2.8 7.6 0.2 3.3 3 0 0 3 3 3 0 Ubiquitin-Binding Zinc Finger RhoGEF PF00621.20 ELR10970.1 - 1.7e-25 90.3 8.4 1.6e-16 61.0 2.1 2.3 1 1 1 2 2 2 2 RhoGEF domain Thioredoxin_16 PF18569.1 ELR10970.1 - 0.011 15.8 0.1 0.024 14.8 0.1 1.5 1 0 0 1 1 1 0 Thioredoxin-like domain BTB PF00651.31 ELR10972.1 - 1.7e-17 63.6 0.1 4.2e-17 62.4 0.1 1.7 1 1 0 1 1 1 1 BTB/POZ domain Rad60-SLD PF11976.8 ELR10972.1 - 0.00079 19.2 0.0 0.0018 18.1 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like OsmC PF02566.19 ELR10973.1 - 1.4e-12 48.0 0.0 2.1e-12 47.4 0.0 1.3 1 0 0 1 1 1 1 OsmC-like protein N6_N4_Mtase PF01555.18 ELR10974.1 - 0.0036 17.0 0.0 0.14 11.9 0.0 2.7 2 1 1 3 3 3 1 DNA methylase Fascin PF06268.13 ELR10975.1 - 1.8e-36 124.7 5.8 1.3e-13 51.2 0.1 4.0 2 2 2 4 4 4 4 Fascin domain FRG1 PF06229.12 ELR10975.1 - 2.1e-27 96.1 0.0 5.3e-08 32.8 0.0 4.2 1 1 3 4 4 4 4 FRG1-like domain DUF569 PF04601.13 ELR10975.1 - 1e-17 64.1 0.5 0.00039 20.1 0.0 4.1 3 1 1 4 4 4 4 Domain of unknown function (DUF569) FGF PF00167.18 ELR10975.1 - 7.6e-08 32.5 0.0 0.86 9.7 0.0 4.2 1 1 3 4 4 4 4 Fibroblast growth factor IL8 PF00048.20 ELR10975.1 - 1.3e-05 25.3 0.1 9.3 6.5 0.0 5.7 6 0 0 6 6 6 1 Small cytokines (intecrine/chemokine), interleukin-8 like Fascin PF06268.13 ELR10976.1 - 4.6e-22 78.3 1.2 4.8e-12 46.1 0.1 2.1 1 1 1 2 2 2 2 Fascin domain FRG1 PF06229.12 ELR10976.1 - 1.6e-14 54.1 0.0 1.6e-07 31.3 0.0 2.2 1 1 1 2 2 2 2 FRG1-like domain DUF569 PF04601.13 ELR10976.1 - 3.9e-08 33.1 0.0 0.00096 18.9 0.0 2.2 2 0 0 2 2 2 2 Domain of unknown function (DUF569) FGF PF00167.18 ELR10976.1 - 0.0009 19.3 0.0 0.011 15.9 0.0 2.1 1 1 1 2 2 2 2 Fibroblast growth factor IL8 PF00048.20 ELR10976.1 - 0.053 13.7 0.0 67 3.8 0.0 3.1 3 0 0 3 3 3 0 Small cytokines (intecrine/chemokine), interleukin-8 like Fascin PF06268.13 ELR10977.1 - 5.1e-13 49.2 0.1 6e-13 49.0 0.1 1.0 1 0 0 1 1 1 1 Fascin domain FRG1 PF06229.12 ELR10977.1 - 1.8e-09 37.6 0.0 8.8e-09 35.3 0.0 1.8 1 1 0 1 1 1 1 FRG1-like domain DUF569 PF04601.13 ELR10977.1 - 0.00012 21.8 0.0 0.00015 21.4 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF569) FGF PF00167.18 ELR10977.1 - 0.00026 21.1 0.0 0.35 11.0 0.0 2.0 1 1 1 2 2 2 2 Fibroblast growth factor IPK PF03770.16 ELR10978.1 - 3.5e-31 108.6 0.0 5.9e-31 107.9 0.0 1.3 1 0 0 1 1 1 1 Inositol polyphosphate kinase C1_1 PF00130.22 ELR10978.1 - 2.3e-07 30.6 2.7 4.4e-07 29.7 2.7 1.4 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) VHP PF02209.19 ELR10979.1 - 5.3e-13 48.8 0.1 1.4e-12 47.5 0.1 1.8 1 0 0 1 1 1 1 Villin headpiece domain MAP7 PF05672.11 ELR10979.1 - 3.6e-06 26.8 30.1 3.6e-06 26.8 30.1 3.5 3 0 0 3 3 3 1 MAP7 (E-MAP-115) family CAF-1_p150 PF11600.8 ELR10979.1 - 0.00072 19.3 34.8 0.00072 19.3 34.8 3.4 3 0 0 3 3 3 2 Chromatin assembly factor 1 complex p150 subunit, N-terminal SH2 PF00017.24 ELR10979.1 - 0.0065 16.5 0.0 0.019 15.1 0.0 1.8 1 0 0 1 1 1 1 SH2 domain Cbl_N2 PF02761.14 ELR10979.1 - 0.013 16.2 1.0 0.027 15.2 1.0 1.5 1 0 0 1 1 1 0 CBL proto-oncogene N-terminus, EF hand-like domain TMEM171 PF15471.6 ELR10979.1 - 0.44 9.5 4.9 1.4 7.8 4.9 1.8 1 0 0 1 1 1 0 Transmembrane protein family 171 F-box-like PF12937.7 ELR10980.1 - 3.4e-05 23.7 0.4 8.9e-05 22.3 0.2 1.9 1 1 0 1 1 1 1 F-box-like R-HINP1I PF11463.8 ELR10980.1 - 0.039 13.4 0.2 0.067 12.6 0.2 1.4 1 0 0 1 1 1 0 R.HinP1I restriction endonuclease F-box PF00646.33 ELR10980.1 - 0.12 12.3 0.0 0.28 11.1 0.0 1.6 1 0 0 1 1 1 0 F-box domain RasGAP PF00616.19 ELR10981.1 - 2.6e-28 99.2 0.1 4.1e-17 62.6 0.1 2.1 1 1 1 2 2 2 2 GTPase-activator protein for Ras-like GTPase DUF1635 PF07795.11 ELR10982.1 - 0.00037 20.4 1.0 0.00067 19.6 1.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1635) Exonuc_VII_L PF02601.15 ELR10982.1 - 0.0085 15.7 7.4 0.012 15.2 7.4 1.1 1 0 0 1 1 1 1 Exonuclease VII, large subunit DUF4407 PF14362.6 ELR10982.1 - 0.065 12.6 9.7 0.086 12.2 9.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) IPK PF03770.16 ELR10982.1 - 0.36 10.7 3.0 0.51 10.2 3.0 1.1 1 0 0 1 1 1 0 Inositol polyphosphate kinase DUF612 PF04747.12 ELR10982.1 - 1.4 7.9 13.1 1.8 7.6 13.1 1.2 1 0 0 1 1 1 0 Protein of unknown function, DUF612 FUSC PF04632.12 ELR10982.1 - 2.1 6.8 5.3 2.6 6.5 5.3 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family Tho2 PF11262.8 ELR10982.1 - 2.5 7.2 10.9 3.6 6.7 10.9 1.2 1 0 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 DDE_Tnp_IS66 PF03050.14 ELR10982.1 - 5.3 6.4 11.9 7.3 6.0 11.9 1.1 1 0 0 1 1 1 0 Transposase IS66 family Sec2p PF06428.11 ELR10982.1 - 6.5 6.8 20.2 11 6.0 20.2 1.4 1 1 0 1 1 1 0 GDP/GTP exchange factor Sec2p V_ATPase_I PF01496.19 ELR10982.1 - 7.1 4.4 7.7 8.9 4.1 7.7 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family GTP_cyclohydroI PF01227.22 ELR10984.1 - 2e-32 112.1 0.0 2.6e-32 111.7 0.0 1.2 1 0 0 1 1 1 1 GTP cyclohydrolase I AAA_28 PF13521.6 ELR10985.1 - 0.037 14.3 0.0 0.067 13.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain RRN9 PF10680.9 ELR10986.1 - 0.4 11.0 3.3 0.74 10.1 3.3 1.4 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor Kelch_2 PF07646.15 ELR10987.1 - 1.6e-34 116.6 4.1 1e-07 31.6 0.0 6.4 6 0 0 6 6 6 6 Kelch motif Kelch_5 PF13854.6 ELR10987.1 - 2.5e-32 110.3 10.0 5e-07 29.6 0.1 6.3 6 0 0 6 6 6 5 Kelch motif Kelch_1 PF01344.25 ELR10987.1 - 5.1e-32 109.2 0.5 9.8e-09 34.7 0.0 6.2 6 0 0 6 6 6 6 Kelch motif Kelch_6 PF13964.6 ELR10987.1 - 3.5e-31 106.4 6.3 2.8e-09 36.9 0.0 6.3 5 1 1 6 6 6 6 Kelch motif Kelch_4 PF13418.6 ELR10987.1 - 3.3e-30 103.8 10.1 9.8e-08 31.9 0.1 6.2 6 0 0 6 6 6 5 Galactose oxidase, central domain BTB PF00651.31 ELR10987.1 - 1.8e-26 92.5 0.9 1.2e-13 51.3 0.1 2.6 3 0 0 3 3 3 2 BTB/POZ domain Kelch_3 PF13415.6 ELR10987.1 - 8.8e-23 80.1 9.1 1.1e-10 41.5 0.1 5.9 5 1 0 5 5 5 3 Galactose oxidase, central domain Ank_4 PF13637.6 ELR10987.1 - 9.7e-09 35.6 0.1 0.00025 21.6 0.0 2.3 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 ELR10987.1 - 1e-06 29.2 0.0 1.9e-06 28.4 0.0 1.5 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.30 ELR10987.1 - 1.4e-06 28.5 0.0 4.6e-06 26.8 0.0 2.0 1 0 0 1 1 1 1 Ankyrin repeat Ank_5 PF13857.6 ELR10987.1 - 0.0001 22.5 0.0 0.00041 20.6 0.0 2.0 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 ELR10987.1 - 0.0011 19.3 0.0 0.0045 17.4 0.0 2.1 1 0 0 1 1 1 1 Ankyrin repeat BILBO1_N PF18281.1 ELR10987.1 - 0.064 13.7 0.0 2.1 8.9 0.0 2.6 2 0 0 2 2 2 0 BILBO1 N-terminal domain ANAPC4_WD40 PF12894.7 ELR10988.1 - 1.3e-07 31.8 0.0 0.028 14.7 0.0 3.2 3 0 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 ELR10988.1 - 6.1e-05 23.7 1.5 0.12 13.2 0.0 3.3 3 0 0 3 3 3 2 WD domain, G-beta repeat PD40 PF07676.12 ELR10988.1 - 0.058 13.3 0.9 1.6 8.7 0.0 3.3 3 1 0 3 3 3 0 WD40-like Beta Propeller Repeat F-box-like PF12937.7 ELR10990.1 - 5e-09 35.9 0.1 6.8e-09 35.5 0.1 1.2 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ELR10990.1 - 0.0014 18.5 0.0 0.0024 17.7 0.0 1.4 1 1 0 1 1 1 1 F-box domain DUF3343 PF11823.8 ELR10990.1 - 0.056 12.9 0.1 0.084 12.4 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3343) CBS PF00571.28 ELR10992.1 - 9.9e-12 45.1 0.3 6.9e-06 26.4 0.1 2.3 2 0 0 2 2 2 2 CBS domain MORN PF02493.20 ELR10992.1 - 4.7e-10 38.8 17.4 2.6e-06 27.0 1.8 2.8 3 0 0 3 3 3 2 MORN repeat Cas_Cas5d PF09704.10 ELR10993.1 - 0.18 11.7 0.0 0.2 11.5 0.0 1.1 1 0 0 1 1 1 0 CRISPR-associated protein (Cas_Cas5) O-FucT PF10250.9 ELR10994.1 - 0.06 13.0 0.0 0.11 12.2 0.0 1.3 1 1 0 1 1 1 0 GDP-fucose protein O-fucosyltransferase Exo_endo_phos PF03372.23 ELR10995.1 - 0.15 11.6 0.1 0.15 11.5 0.1 1.2 1 0 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos PF03372.23 ELR10999.1 - 1.2e-15 57.7 2.0 2.9e-14 53.2 2.0 2.1 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family GST_N PF02798.20 ELR11000.1 - 4e-14 52.7 0.0 4.7e-14 52.5 0.0 1.1 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 ELR11000.1 - 2.5e-06 27.8 0.0 2.8e-06 27.6 0.0 1.1 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain Glutaredoxin PF00462.24 ELR11000.1 - 0.19 12.0 0.0 0.3 11.3 0.0 1.3 1 0 0 1 1 1 0 Glutaredoxin CST-I PF06002.12 ELR11001.1 - 0.052 13.3 0.0 0.07 12.9 0.0 1.1 1 0 0 1 1 1 0 Alpha-2,3-sialyltransferase (CST-I) RET_CLD4 PF17813.1 ELR11001.1 - 0.072 13.4 0.1 0.08 13.2 0.1 1.1 1 0 0 1 1 1 0 RET Cadherin like domain 4 Bromodomain PF00439.25 ELR11002.1 - 1.7e-16 60.0 0.2 2.7e-16 59.4 0.2 1.3 1 0 0 1 1 1 1 Bromodomain E1-E2_ATPase PF00122.20 ELR11003.1 - 7.4e-42 142.9 3.6 1.7e-41 141.7 0.3 2.8 3 0 0 3 3 3 1 E1-E2 ATPase Hydrolase PF00702.26 ELR11003.1 - 7.5e-17 62.3 0.8 1.3e-16 61.5 0.8 1.4 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 ELR11003.1 - 1.6e-14 53.3 0.0 3.9e-13 48.9 0.0 3.0 4 0 0 4 4 4 1 Cation transporter/ATPase, N-terminus Cation_ATPase PF13246.6 ELR11003.1 - 0.0086 16.1 0.0 0.024 14.7 0.0 1.8 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 ELR11003.1 - 0.021 14.5 0.1 0.021 14.5 0.1 2.1 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase Cation_ATPase_C PF00689.21 ELR11003.1 - 0.25 11.1 7.4 0.024 14.4 1.0 2.5 3 0 0 3 3 3 0 Cation transporting ATPase, C-terminus OB_NTP_bind PF07717.16 ELR11004.1 - 2.5e-22 79.0 0.1 3.5e-22 78.6 0.1 1.2 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold SlyX PF04102.12 ELR11005.1 - 0.0087 16.6 3.2 0.53 10.9 0.2 2.5 1 1 1 2 2 2 1 SlyX Fez1 PF06818.15 ELR11005.1 - 0.015 15.8 2.3 0.023 15.2 2.3 1.2 1 0 0 1 1 1 0 Fez1 Taxilin PF09728.9 ELR11005.1 - 0.025 13.8 6.4 0.04 13.1 6.4 1.3 1 0 0 1 1 1 0 Myosin-like coiled-coil protein GBR_NSP5 PF17580.2 ELR11005.1 - 0.026 14.4 1.8 0.04 13.7 1.8 1.2 1 0 0 1 1 1 0 Group B Rotavirus Non-structural protein 5 bZIP_1 PF00170.21 ELR11005.1 - 0.028 14.5 4.6 0.17 12.0 0.0 2.4 2 0 0 2 2 2 0 bZIP transcription factor Herpes_UL6 PF01763.16 ELR11005.1 - 0.038 12.5 1.3 0.052 12.1 1.3 1.1 1 0 0 1 1 1 0 Herpesvirus UL6 like JAKMIP_CC3 PF16034.5 ELR11005.1 - 0.074 13.0 2.3 0.13 12.2 2.3 1.3 1 0 0 1 1 1 0 JAKMIP CC3 domain PAS_9 PF13426.7 ELR11005.1 - 0.17 12.2 0.0 0.4 11.0 0.0 1.6 1 0 0 1 1 1 0 PAS domain DUF724 PF05266.14 ELR11005.1 - 0.25 11.2 3.4 0.39 10.5 3.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF724) DUF4519 PF15012.6 ELR11005.1 - 1.3 9.2 9.2 2.4 8.4 9.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4519) Protocadherin PF08374.11 ELR11005.1 - 2.6 8.0 5.8 0.66 9.9 0.5 2.1 2 0 0 2 2 2 0 Protocadherin LAMTOR PF15454.6 ELR11006.1 - 0.00015 22.3 0.6 0.00033 21.2 0.4 1.8 1 1 0 1 1 1 1 Late endosomal/lysosomal adaptor and MAPK and MTOR activator NSP2-B_epitope PF14757.6 ELR11006.1 - 0.047 13.4 3.1 0.17 11.6 3.1 1.7 1 1 0 1 1 1 0 Immunogenic region of nsp2 protein of arterivirus polyprotein RasGEF_N PF00618.20 ELR11007.1 - 4.3e-06 26.9 0.1 6.7e-06 26.3 0.1 1.2 1 0 0 1 1 1 1 RasGEF N-terminal motif VWA_3 PF13768.6 ELR11007.1 - 0.00069 19.6 0.0 0.00083 19.3 0.0 1.0 1 0 0 1 1 1 1 von Willebrand factor type A domain Peptidase_C54 PF03416.19 ELR11008.1 - 2.8e-43 148.3 0.0 3.6e-43 148.0 0.0 1.1 1 0 0 1 1 1 1 Peptidase family C54 DUF3446 PF11928.8 ELR11008.1 - 0.0075 16.5 11.6 0.013 15.8 11.6 1.4 1 0 0 1 1 1 1 Early growth response N-terminal domain DUF3558 PF12079.8 ELR11008.1 - 0.019 15.0 4.1 0.025 14.6 4.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3558) SR-25 PF10500.9 ELR11008.1 - 1.6 8.3 17.7 2.1 7.9 17.7 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein RAP1 PF07218.11 ELR11008.1 - 5.3 5.2 10.1 6.6 4.9 10.1 1.0 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) Ank_2 PF12796.7 ELR11009.1 - 0.0055 17.3 0.0 0.23 12.1 0.0 1.7 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ELR11009.1 - 0.037 14.6 0.2 0.82 10.3 0.1 2.5 1 1 2 3 3 3 0 Ankyrin repeats (many copies) HPP PF04982.13 ELR11010.1 - 5.8e-26 91.1 10.9 5.8e-26 91.1 10.9 1.5 1 1 0 1 1 1 1 HPP family BT1 PF03092.16 ELR11010.1 - 0.33 9.1 4.6 7.3 4.7 0.0 2.2 2 0 0 2 2 2 0 BT1 family Transgly_assoc PF04226.13 ELR11010.1 - 8.7 6.7 9.8 19 5.6 1.3 2.9 2 1 0 2 2 2 0 Transglycosylase associated protein DUF455 PF04305.14 ELR11011.1 - 1.1e-63 215.0 0.0 1.5e-63 214.6 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF455) FGE-sulfatase PF03781.16 ELR11014.1 - 5.4e-31 108.1 2.3 9.8e-31 107.3 2.3 1.4 1 0 0 1 1 1 1 Sulfatase-modifying factor enzyme 1 Methyltransf_31 PF13847.6 ELR11014.1 - 2.4e-07 30.7 0.0 5.7e-07 29.4 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 ELR11014.1 - 0.00011 22.1 0.0 0.00022 21.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ELR11014.1 - 0.00013 22.6 0.0 0.00026 21.6 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ELR11014.1 - 0.0011 19.6 0.0 0.0061 17.2 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ELR11014.1 - 0.0019 18.9 0.0 0.0082 16.9 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 ELR11014.1 - 0.18 11.1 0.0 0.27 10.6 0.0 1.3 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family zf-C2H2 PF00096.26 ELR11015.1 - 3.1e-34 115.5 56.5 4.1e-06 26.9 0.9 9.3 9 0 0 9 9 9 9 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 ELR11015.1 - 3.8e-17 61.5 56.3 0.0033 18.1 0.4 9.1 8 1 1 9 9 9 7 C2H2-type zinc finger zf-H2C2_2 PF13465.6 ELR11015.1 - 7.9e-15 54.5 60.5 0.0002 21.6 0.4 9.6 10 1 0 10 10 9 6 Zinc-finger double domain FOXP-CC PF16159.5 ELR11015.1 - 1.3e-06 28.9 24.8 0.097 13.3 1.0 7.3 5 2 2 7 7 7 3 FOXP coiled-coil domain zf-met PF12874.7 ELR11015.1 - 1.3e-05 25.4 20.4 0.2 12.1 0.1 6.5 6 0 0 6 6 6 1 Zinc-finger of C2H2 type zf-C2H2_8 PF15909.5 ELR11015.1 - 9e-05 22.7 20.9 0.091 13.1 6.9 4.6 2 2 1 3 3 3 3 C2H2-type zinc ribbon zf-C2H2_jaz PF12171.8 ELR11015.1 - 0.00019 21.6 24.1 5.3 7.4 0.0 7.6 8 0 0 8 8 7 1 Zinc-finger double-stranded RNA-binding zf_C2H2_ZHX PF18387.1 ELR11015.1 - 0.016 14.9 1.0 0.016 14.9 1.0 4.6 4 2 1 5 5 5 0 Zinc-fingers and homeoboxes C2H2 finger domain zf-C2H2_11 PF16622.5 ELR11015.1 - 0.087 12.6 0.5 0.087 12.6 0.5 6.2 7 0 0 7 7 7 0 zinc-finger C2H2-type zf-BED PF02892.15 ELR11015.1 - 0.1 12.6 0.3 0.1 12.6 0.3 5.5 5 1 1 6 6 5 0 BED zinc finger UNC-79 PF14776.6 ELR11015.1 - 0.31 9.8 0.5 0.5 9.1 0.5 1.2 1 0 0 1 1 1 0 Cation-channel complex subunit UNC-79 zf-C2HC_2 PF13913.6 ELR11015.1 - 0.36 10.8 0.1 0.36 10.8 0.1 6.1 7 0 0 7 7 7 0 zinc-finger of a C2HC-type zf-C2HE PF16278.5 ELR11015.1 - 0.73 10.3 0.0 0.73 10.3 0.0 4.7 5 1 1 6 6 6 0 C2HE / C2H2 / C2HC zinc-binding finger DUF4157 PF13699.6 ELR11015.1 - 2 8.7 5.8 7.1 6.9 0.9 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4157) Vps51 PF08700.11 ELR11017.1 - 7.6e-11 42.0 0.1 4.6e-10 39.5 0.1 2.4 2 0 0 2 2 2 1 Vps51/Vps67 Serglycin PF04360.12 ELR11017.1 - 4.4e-05 23.5 0.1 0.0001 22.3 0.1 1.6 1 0 0 1 1 1 1 Serglycin Period_C PF12114.8 ELR11017.1 - 0.00055 19.6 2.6 0.0014 18.2 2.6 1.7 1 0 0 1 1 1 1 Period protein 2/3C-terminal region Sec5 PF15469.6 ELR11017.1 - 0.066 13.0 0.0 0.16 11.8 0.0 1.6 1 0 0 1 1 1 0 Exocyst complex component Sec5 Caldesmon PF02029.15 ELR11017.1 - 3.3 6.4 10.0 6.8 5.3 10.0 1.4 1 0 0 1 1 1 0 Caldesmon MORN PF02493.20 ELR11018.1 - 1.3e-50 166.4 130.0 2.8e-08 33.2 6.0 14.0 14 0 0 14 14 14 12 MORN repeat F-box-like PF12937.7 ELR11018.1 - 1.9e-05 24.4 0.0 3.1e-05 23.8 0.0 1.3 1 0 0 1 1 1 1 F-box-like RRM_1 PF00076.22 ELR11019.1 - 5.6e-76 250.3 5.6 5.6e-19 67.7 0.0 5.7 5 0 0 5 5 5 5 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 ELR11019.1 - 1.3e-09 37.7 0.0 0.042 13.4 0.1 5.2 4 1 1 5 5 5 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 ELR11019.1 - 1.8e-06 27.7 0.0 0.26 11.1 0.0 4.5 4 1 0 4 4 4 2 Occluded RNA-recognition motif Nup35_RRM_2 PF14605.6 ELR11019.1 - 5.8e-05 23.0 0.0 4.5 7.3 0.0 4.4 4 0 0 4 4 4 2 Nup53/35/40-type RNA recognition motif RRM_Rrp7 PF17799.1 ELR11019.1 - 0.00019 21.2 0.7 2.3 8.0 0.1 4.5 4 0 0 4 4 4 1 Rrp7 RRM-like N-terminal domain CDC45 PF02724.14 ELR11019.1 - 0.00028 19.3 13.6 0.00028 19.3 13.6 2.4 2 0 0 2 2 2 1 CDC45-like protein CMS1 PF14617.6 ELR11019.1 - 0.033 13.5 20.7 0.034 13.5 4.2 2.7 2 0 0 2 2 2 0 U3-containing 90S pre-ribosomal complex subunit Zip PF02535.22 ELR11019.1 - 1.3 8.2 10.4 0.11 11.7 4.5 2.0 2 0 0 2 2 2 0 ZIP Zinc transporter PAC1 PF16094.5 ELR11020.1 - 0.00019 20.7 0.0 0.00026 20.2 0.0 1.1 1 0 0 1 1 1 1 Proteasome assembly chaperone 4 Glyco_hydro_43 PF04616.14 ELR11021.1 - 0.062 12.6 0.2 0.11 11.7 0.0 1.4 2 0 0 2 2 2 0 Glycosyl hydrolases family 43 Peptidase_S28 PF05577.12 ELR11022.1 - 1.8e-44 152.3 3.1 3.5e-44 151.3 3.1 1.5 1 1 0 1 1 1 1 Serine carboxypeptidase S28 DUF2976 PF11190.8 ELR11022.1 - 0.023 14.5 0.1 0.072 12.9 0.1 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2976) Complex1_LYR_2 PF13233.6 ELR11023.1 - 0.044 14.5 6.6 0.049 14.4 0.0 2.9 3 0 0 3 3 3 0 Complex1_LYR-like Snf7 PF03357.21 ELR11024.1 - 6e-34 117.1 19.9 7.6e-34 116.8 19.9 1.1 1 0 0 1 1 1 1 Snf7 TINF2_N PF14973.6 ELR11024.1 - 0.037 14.4 7.1 0.064 13.6 6.9 1.5 1 1 0 1 1 1 0 TERF1-interacting nuclear factor 2 N-terminus Mut7-C PF01927.16 ELR11024.1 - 0.14 12.3 3.9 0.13 12.3 2.4 1.8 2 1 0 2 2 2 0 Mut7-C RNAse domain DUF1492 PF07374.11 ELR11024.1 - 1.4 9.2 5.0 0.35 11.0 0.9 2.0 2 1 1 3 3 3 0 Protein of unknown function (DUF1492) DUF747 PF05346.11 ELR11025.1 - 8.2e-46 156.9 13.3 1e-45 156.6 13.3 1.1 1 0 0 1 1 1 1 Eukaryotic membrane protein family ELYS PF13934.6 ELR11026.1 - 3.6e-31 108.9 1.8 8.7e-31 107.6 1.8 1.7 1 0 0 1 1 1 1 Nuclear pore complex assembly ELYS-bb PF16687.5 ELR11026.1 - 3.5e-08 32.5 0.0 5.6e-08 31.8 0.0 1.2 1 0 0 1 1 1 1 beta-propeller of ELYS nucleoporin HMG_CoA_synt_N PF01154.17 ELR11028.1 - 1.6e-90 301.6 0.8 2.5e-90 301.0 0.8 1.3 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A synthase N terminal HMG_CoA_synt_C PF08540.10 ELR11028.1 - 1.1e-84 284.3 1.6 1.5e-84 283.9 1.6 1.2 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A synthase C terminal Thiolase_N PF00108.23 ELR11028.1 - 0.26 10.6 2.2 1.3 8.3 0.0 2.3 2 0 0 2 2 2 0 Thiolase, N-terminal domain Pkinase_Tyr PF07714.17 ELR11029.1 - 3.4e-59 200.2 0.0 4.9e-59 199.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ELR11029.1 - 5e-46 157.2 0.0 7.8e-46 156.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain PH PF00169.29 ELR11029.1 - 7.2e-16 58.6 3.2 3.3e-15 56.5 1.4 2.5 3 0 0 3 3 3 1 PH domain PH_11 PF15413.6 ELR11029.1 - 8.4e-08 32.6 4.4 1.3e-06 28.8 3.2 2.7 2 1 0 2 2 2 1 Pleckstrin homology domain PH_8 PF15409.6 ELR11029.1 - 2.4e-05 24.5 1.1 0.0015 18.8 0.8 2.9 3 0 0 3 3 3 1 Pleckstrin homology domain Pkinase_fungal PF17667.1 ELR11029.1 - 0.0021 16.9 0.0 0.0042 15.9 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase SH2 PF00017.24 ELR11029.1 - 0.06 13.4 0.0 0.18 11.9 0.0 1.9 1 0 0 1 1 1 0 SH2 domain Cbl_N2 PF02761.14 ELR11029.1 - 0.13 12.9 0.1 1 10.1 0.0 2.4 2 0 0 2 2 2 0 CBL proto-oncogene N-terminus, EF hand-like domain Proteasome PF00227.26 ELR11030.1 - 6.7e-47 159.4 0.2 8.1e-47 159.2 0.2 1.1 1 0 0 1 1 1 1 Proteasome subunit DUF3991 PF13154.6 ELR11030.1 - 0.076 13.4 0.1 0.21 11.9 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3991) Ribosomal_S5 PF00333.20 ELR11031.1 - 7.2e-30 102.8 1.8 1.5e-29 101.8 1.2 1.8 2 0 0 2 2 2 1 Ribosomal protein S5, N-terminal domain Ribosomal_S5_C PF03719.15 ELR11031.1 - 2.2e-24 84.7 0.0 4e-24 83.9 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein S5, C-terminal domain Presenilin PF01080.17 ELR11032.1 - 2.7 6.7 8.6 2.6 6.7 8.6 1.2 1 0 0 1 1 1 0 Presenilin Red1 PF07964.11 ELR11032.1 - 3.8 5.6 15.4 3.3 5.8 15.4 1.2 1 0 0 1 1 1 0 Rec10 / Red1 DUF4551 PF15087.6 ELR11032.1 - 5.7 5.6 10.5 7.1 5.3 10.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) NPR3 PF03666.13 ELR11032.1 - 7.2 5.3 15.7 8.2 5.1 15.7 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Pkinase PF00069.25 ELR11033.1 - 1.7e-54 185.0 0.0 2.2e-54 184.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR11033.1 - 1.1e-22 80.6 0.0 1.6e-22 80.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Choline_kinase PF01633.20 ELR11033.1 - 0.0054 16.3 0.3 0.0096 15.5 0.3 1.4 1 0 0 1 1 1 1 Choline/ethanolamine kinase APH PF01636.23 ELR11033.1 - 0.024 14.5 0.1 0.045 13.7 0.1 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Seipin PF06775.14 ELR11034.1 - 3.2e-43 148.1 0.0 4.5e-43 147.6 0.0 1.2 1 0 0 1 1 1 1 Putative adipose-regulatory protein (Seipin) Nop14 PF04147.12 ELR11034.1 - 1.1 7.4 10.7 1.4 7.1 10.7 1.2 1 0 0 1 1 1 0 Nop14-like family DTHCT PF08070.11 ELR11034.1 - 1.7 9.4 7.5 0.098 13.4 1.9 1.8 2 0 0 2 2 2 0 DTHCT (NUC029) region PI3K_1B_p101 PF10486.9 ELR11034.1 - 1.9 6.2 3.3 2.5 5.8 3.3 1.1 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit RhoGAP PF00620.27 ELR11035.1 - 8.4e-33 113.3 2.6 2.2e-32 112.0 0.0 2.7 3 0 0 3 3 3 1 RhoGAP domain RhoGEF PF00621.20 ELR11035.1 - 7.9e-05 23.0 0.2 7.9e-05 23.0 0.2 2.9 3 2 0 3 3 3 1 RhoGEF domain BAR PF03114.18 ELR11035.1 - 0.00061 19.5 5.2 0.00061 19.5 5.2 2.3 2 0 0 2 2 2 1 BAR domain PH PF00169.29 ELR11035.1 - 0.062 13.8 0.0 0.16 12.5 0.0 1.7 1 0 0 1 1 1 0 PH domain DUF1759 PF03564.15 ELR11035.1 - 3.7 7.5 7.4 0.9 9.5 0.6 3.2 3 1 1 4 4 4 0 Protein of unknown function (DUF1759) COMPASS-Shg1 PF05205.12 ELR11035.1 - 6.6 7.5 8.4 2.6 8.8 0.7 3.6 4 0 0 4 4 4 0 COMPASS (Complex proteins associated with Set1p) component shg1 RasGAP PF00616.19 ELR11037.1 - 5.4e-28 98.1 6.5 2.4e-20 73.1 0.0 3.9 3 1 1 4 4 4 2 GTPase-activator protein for Ras-like GTPase Mpp10 PF04006.12 ELR11037.1 - 0.0034 15.9 11.4 0.0034 15.9 11.4 2.1 2 0 0 2 2 2 2 Mpp10 protein eIF3_subunit PF08597.10 ELR11037.1 - 0.062 13.2 17.8 0.04 13.8 8.7 2.3 2 0 0 2 2 2 0 Translation initiation factor eIF3 subunit ABC_ATPase PF09818.9 ELR11037.1 - 0.093 11.5 1.2 0.14 10.9 1.2 1.2 1 0 0 1 1 1 0 Predicted ATPase of the ABC class Adaptin_binding PF10199.9 ELR11037.1 - 0.65 10.6 11.9 0.64 10.6 0.3 2.5 2 0 0 2 2 2 0 Alpha and gamma adaptin binding protein p34 HA2 PF04408.23 ELR11037.1 - 1.9 8.8 5.9 28 5.1 2.8 2.6 2 0 0 2 2 2 0 Helicase associated domain (HA2) DUF2052 PF09747.9 ELR11037.1 - 2.2 8.4 19.8 3.4 7.7 10.9 2.2 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) DUF4820 PF16091.5 ELR11037.1 - 2.5 7.4 12.1 0.51 9.7 5.6 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4820) TRAP_alpha PF03896.16 ELR11037.1 - 4.6 6.3 6.1 6.4 5.9 1.5 2.1 2 0 0 2 2 2 0 Translocon-associated protein (TRAP), alpha subunit eIF3_subunit PF08597.10 ELR11038.1 - 0.15 12.0 19.3 0.2 11.5 19.3 1.2 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit Ferritin-like PF12902.7 ELR11038.1 - 0.23 11.3 3.5 0.33 10.8 3.5 1.2 1 0 0 1 1 1 0 Ferritin-like CNDH2_M PF16869.5 ELR11038.1 - 0.56 10.9 3.8 1 10.0 3.8 1.3 1 0 0 1 1 1 0 PF16858 DUF913 PF06025.12 ELR11038.1 - 1.5 7.7 4.9 1.9 7.4 4.9 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Gastrin PF00918.17 ELR11038.1 - 3.5 8.6 6.0 0.73 10.8 0.9 1.9 1 1 1 2 2 2 0 Gastrin/cholecystokinin family DEP PF00610.21 ELR11039.1 - 1.5e-29 101.9 0.2 1.7e-13 50.4 0.0 2.2 2 0 0 2 2 2 2 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) PEX-2N PF09263.10 ELR11039.1 - 0.018 15.3 0.7 0.11 12.8 0.0 2.3 2 1 0 2 2 2 0 Peroxisome biogenesis factor 1, N-terminal Rieske PF00355.26 ELR11040.1 - 7.8e-22 77.0 0.1 1.5e-21 76.1 0.1 1.4 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain Rieske_2 PF13806.6 ELR11040.1 - 0.0081 16.1 0.0 0.014 15.3 0.0 1.4 1 0 0 1 1 1 1 Rieske-like [2Fe-2S] domain DUF987 PF06174.11 ELR11040.1 - 0.016 15.1 0.0 0.037 14.0 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF987) ACOX PF01756.19 ELR11041.1 - 5.6e-56 188.9 0.4 1.6e-55 187.5 0.1 1.8 2 0 0 2 2 2 1 Acyl-CoA oxidase Acyl-CoA_ox_N PF14749.6 ELR11041.1 - 1.4e-24 87.1 0.4 3.9e-24 85.6 0.2 1.9 2 0 0 2 2 2 1 Acyl-coenzyme A oxidase N-terminal Acyl-CoA_dh_M PF02770.19 ELR11041.1 - 6.3e-15 55.2 0.1 1.2e-14 54.3 0.1 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_1 PF00441.24 ELR11041.1 - 0.0038 17.5 0.4 0.037 14.2 0.4 2.7 1 1 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Toxin_5 PF05294.13 ELR11041.1 - 0.078 13.4 1.1 0.18 12.3 1.1 1.5 1 0 0 1 1 1 0 Scorpion short toxin ERM PF00769.19 ELR11042.1 - 0.001 19.0 18.9 0.001 19.0 18.9 5.8 5 1 0 6 6 6 2 Ezrin/radixin/moesin family DUF1735 PF08522.10 ELR11043.1 - 0.085 13.5 0.1 0.28 11.8 0.1 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF1735) DUF3972 PF13118.6 ELR11044.1 - 0.16 12.4 2.7 0.28 11.6 2.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3972) TetR_C_24 PF17932.1 ELR11044.1 - 1.5 9.2 6.1 1.3 9.3 1.6 2.5 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain CLASP_N PF12348.8 ELR11045.1 - 2.1e-28 99.4 0.3 4.4e-28 98.4 0.3 1.5 1 0 0 1 1 1 1 CLASP N terminal VCH_CASS14 PF18315.1 ELR11045.1 - 0.021 14.8 0.0 0.048 13.7 0.0 1.5 1 0 0 1 1 1 0 Integron cassette protein VCH_CASS1 chain Tti2 PF10521.9 ELR11045.1 - 0.027 14.0 0.2 3.7 7.0 0.0 2.5 2 0 0 2 2 2 0 Tti2 family HEAT PF02985.22 ELR11045.1 - 0.26 11.7 3.5 24 5.5 0.0 4.0 4 0 0 4 4 4 0 HEAT repeat HECT PF00632.25 ELR11046.1 - 2.9e-56 191.2 0.0 4.4e-56 190.6 0.0 1.2 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) SPRY PF00622.28 ELR11046.1 - 0.0024 18.0 0.0 0.0074 16.4 0.0 1.8 1 1 0 1 1 1 1 SPRY domain zf-RanBP PF00641.18 ELR11046.1 - 0.007 15.7 2.8 0.013 14.8 2.8 1.4 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others Spt20 PF12090.8 ELR11046.1 - 1.5 8.3 5.2 3.2 7.3 5.2 1.4 1 0 0 1 1 1 0 Spt20 family COPI_C PF06957.11 ELR11048.1 - 6.2e-126 420.4 0.0 9.4e-126 419.8 0.0 1.2 1 0 0 1 1 1 1 Coatomer (COPI) alpha subunit C-terminus Coatomer_WDAD PF04053.14 ELR11048.1 - 4.1e-125 418.3 0.0 8.1e-125 417.3 0.0 1.5 2 0 0 2 2 2 1 Coatomer WD associated region WD40 PF00400.32 ELR11048.1 - 2e-44 148.7 12.8 4e-08 33.8 0.1 7.7 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ELR11048.1 - 2.3e-08 34.2 0.5 0.00036 20.8 0.0 5.1 3 1 2 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ELR11048.1 - 0.018 13.7 5.3 2.5 6.7 0.0 3.3 2 1 1 3 3 3 0 Nucleoporin Nup120/160 Sulfate_transp PF00916.20 ELR11049.1 - 4.1e-59 200.3 18.1 1.8e-40 138.9 5.7 3.1 1 1 1 2 2 2 2 Sulfate permease family STAS PF01740.21 ELR11049.1 - 1.1e-17 63.8 0.0 1.8e-17 63.1 0.0 1.3 1 0 0 1 1 1 1 STAS domain STAS_2 PF13466.6 ELR11049.1 - 0.0019 18.5 0.0 0.0037 17.6 0.0 1.4 1 0 0 1 1 1 1 STAS domain Polbeta PF18765.1 ELR11050.1 - 0.0041 17.2 0.0 0.0072 16.4 0.0 1.3 1 0 0 1 1 1 1 Polymerase beta, Nucleotidyltransferase NTP_transf_2 PF01909.23 ELR11050.1 - 0.016 15.5 0.0 0.031 14.6 0.0 1.4 1 0 0 1 1 1 0 Nucleotidyltransferase domain RlaP PF10127.9 ELR11050.1 - 0.15 11.6 0.4 0.64 9.6 0.1 1.9 2 0 0 2 2 2 0 RNA repair pathway DNA polymerase beta family CfAFP PF05264.11 ELR11050.1 - 0.23 11.4 0.8 0.46 10.5 0.8 1.4 1 0 0 1 1 1 0 Choristoneura fumiferana antifreeze protein (CfAFP) Mito_carr PF00153.27 ELR11051.1 - 3.8e-47 158.2 2.6 4.4e-16 58.6 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Sod_Cu PF00080.20 ELR11052.1 - 1e-51 174.8 4.8 1.2e-51 174.6 4.8 1.0 1 0 0 1 1 1 1 Copper/zinc superoxide dismutase (SODC) Noelin-1 PF12308.8 ELR11053.1 - 0.08 12.9 2.5 0.17 11.9 2.5 1.5 1 0 0 1 1 1 0 Neurogenesis glycoprotein Cys_box PF17869.1 ELR11053.1 - 0.21 11.7 0.7 0.4 10.8 0.7 1.4 1 0 0 1 1 1 0 Anosmin cysteine rich domain TPR_2 PF07719.17 ELR11054.1 - 1.7e-49 162.0 46.6 3.2e-05 23.7 0.6 17.4 18 0 0 18 18 16 11 Tetratricopeptide repeat TPR_1 PF00515.28 ELR11054.1 - 4.2e-49 162.4 43.5 8.9e-06 25.3 1.5 17.0 17 0 0 17 17 17 10 Tetratricopeptide repeat TPR_8 PF13181.6 ELR11054.1 - 7.6e-40 131.8 28.0 0.00018 21.5 0.4 16.8 18 0 0 18 18 18 9 Tetratricopeptide repeat TPR_12 PF13424.6 ELR11054.1 - 1.6e-39 134.1 29.5 1.1e-07 32.0 4.1 10.8 5 3 5 10 10 10 9 Tetratricopeptide repeat TPR_16 PF13432.6 ELR11054.1 - 4.1e-37 126.6 37.5 5.3e-07 30.2 0.2 11.4 7 4 3 11 11 10 7 Tetratricopeptide repeat TPR_19 PF14559.6 ELR11054.1 - 1.5e-36 124.7 27.9 2.1e-06 28.1 0.0 11.0 10 2 1 11 11 10 6 Tetratricopeptide repeat TPR_14 PF13428.6 ELR11054.1 - 9.8e-34 113.2 26.9 1.5e-05 25.4 0.0 14.3 10 3 6 16 16 13 8 Tetratricopeptide repeat TPR_6 PF13174.6 ELR11054.1 - 6e-25 86.2 26.7 0.00069 20.1 0.0 12.8 13 0 0 13 13 12 6 Tetratricopeptide repeat TPR_17 PF13431.6 ELR11054.1 - 2.5e-23 80.7 41.2 0.39 11.2 0.2 17.1 16 1 0 16 16 16 7 Tetratricopeptide repeat TPR_7 PF13176.6 ELR11054.1 - 1.2e-21 75.0 26.6 0.0097 15.9 0.0 13.6 13 1 0 13 13 13 7 Tetratricopeptide repeat TPR_11 PF13414.6 ELR11054.1 - 2.6e-20 71.8 41.4 2.6e-06 27.0 1.3 13.7 13 3 4 17 17 16 8 TPR repeat TPR_9 PF13371.6 ELR11054.1 - 1e-13 51.2 6.2 0.003 17.7 0.1 6.6 5 2 2 7 7 6 3 Tetratricopeptide repeat ANAPC3 PF12895.7 ELR11054.1 - 8.5e-13 48.3 27.5 0.0079 16.4 0.4 6.6 4 2 3 7 7 7 4 Anaphase-promoting complex, cyclosome, subunit 3 TPR_10 PF13374.6 ELR11054.1 - 1.5e-11 43.7 30.3 0.93 9.5 0.0 12.2 12 0 0 12 12 12 3 Tetratricopeptide repeat TPR_15 PF13429.6 ELR11054.1 - 1.7e-05 24.2 17.8 0.0094 15.2 0.1 5.5 1 1 4 5 5 5 3 Tetratricopeptide repeat ChAPs PF09295.10 ELR11054.1 - 0.0002 20.5 2.4 0.044 12.8 0.1 3.2 2 1 1 3 3 3 1 ChAPs (Chs5p-Arf1p-binding proteins) DUF4810 PF16068.5 ELR11054.1 - 0.00022 21.7 5.1 5.3 7.7 0.2 6.7 4 3 1 5 5 5 1 Domain of unknown function (DUF4810) Fis1_TPR_C PF14853.6 ELR11054.1 - 0.00024 21.1 11.2 0.041 13.9 0.1 5.3 5 0 0 5 5 5 1 Fis1 C-terminal tetratricopeptide repeat MIT PF04212.18 ELR11054.1 - 0.00026 21.0 16.5 1.3 9.2 0.3 7.2 6 0 0 6 6 5 2 MIT (microtubule interacting and transport) domain Wzy_C_2 PF11846.8 ELR11054.1 - 0.012 15.6 0.3 0.31 10.9 0.0 3.2 1 1 1 2 2 2 0 Virulence factor membrane-bound polymerase, C-terminal TPR_3 PF07720.12 ELR11054.1 - 0.95 9.5 24.2 0.32 11.0 0.7 6.7 7 0 0 7 7 6 0 Tetratricopeptide repeat Glutaredoxin PF00462.24 ELR11055.1 - 8.9e-40 134.7 0.0 2.6e-18 66.0 0.0 3.3 3 0 0 3 3 3 2 Glutaredoxin Thioredoxin PF00085.20 ELR11055.1 - 2.7e-16 59.4 0.0 6.3e-16 58.2 0.0 1.6 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_9 PF14595.6 ELR11055.1 - 0.00017 21.4 0.0 0.00033 20.4 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin SH3BGR PF04908.15 ELR11055.1 - 0.00025 21.1 0.0 0.87 9.8 0.0 2.5 2 0 0 2 2 2 2 SH3-binding, glutamic acid-rich protein GST_N_3 PF13417.6 ELR11055.1 - 0.0012 19.2 0.0 3.5 8.1 0.0 3.0 3 0 0 3 3 3 2 Glutathione S-transferase, N-terminal domain Thioredoxin_2 PF13098.6 ELR11055.1 - 0.004 17.6 0.0 0.043 14.3 0.0 2.6 2 1 0 2 2 2 1 Thioredoxin-like domain HyaE PF07449.11 ELR11055.1 - 0.0067 16.4 0.1 0.21 11.6 0.0 3.0 3 1 0 3 3 3 1 Hydrogenase-1 expression protein HyaE ZinT PF09223.11 ELR11055.1 - 0.014 15.3 0.0 2.9 7.7 0.0 2.3 2 0 0 2 2 2 0 ZinT (YodA) periplasmic lipocalin-like zinc-recruitment LEM PF03020.15 ELR11055.1 - 0.028 14.0 0.1 7.2 6.3 0.0 2.5 2 0 0 2 2 2 0 LEM domain Thioredoxin_3 PF13192.6 ELR11055.1 - 0.059 13.4 0.1 0.38 10.8 0.0 2.4 2 1 1 3 3 3 0 Thioredoxin domain Thioredoxin_8 PF13905.6 ELR11055.1 - 0.09 13.1 0.1 14 6.0 0.0 2.9 3 1 1 4 4 4 0 Thioredoxin-like PSK_trans_fac PF07704.11 ELR11055.1 - 0.89 10.4 4.7 0.29 11.9 1.4 1.9 2 0 0 2 2 1 0 Rv0623-like transcription factor Sugar_tr PF00083.24 ELR11056.1 - 4e-12 45.7 4.5 4.9e-12 45.5 4.5 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 ELR11056.1 - 1.4e-11 43.9 27.3 2.4e-11 43.1 27.3 1.4 1 0 0 1 1 1 1 Major Facilitator Superfamily PPR_1 PF12854.7 ELR11056.1 - 0.25 11.1 0.7 0.39 10.5 0.7 1.3 1 0 0 1 1 1 0 PPR repeat Sugar_tr PF00083.24 ELR11057.1 - 5.3e-32 111.3 3.3 6e-32 111.1 3.3 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 ELR11057.1 - 1.4e-19 70.2 16.9 1.8e-19 69.9 16.9 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily MFS_2 PF13347.6 ELR11057.1 - 2.4e-05 23.1 4.7 2.4e-05 23.1 4.7 1.9 1 1 1 2 2 2 2 MFS/sugar transport protein MFS_3 PF05977.13 ELR11057.1 - 0.0036 15.8 4.5 0.0049 15.3 4.5 1.2 1 0 0 1 1 1 1 Transmembrane secretion effector MFS_1_like PF12832.7 ELR11057.1 - 0.018 13.9 1.9 0.027 13.3 1.9 1.3 1 0 0 1 1 1 0 MFS_1 like family LacY_symp PF01306.19 ELR11057.1 - 0.16 10.7 3.6 0.21 10.3 3.6 1.2 1 0 0 1 1 1 0 LacY proton/sugar symporter Yae1_N PF09811.9 ELR11059.1 - 0.0014 18.3 3.3 0.0057 16.3 3.3 1.9 1 1 0 1 1 1 1 Essential protein Yae1, N terminal HECT PF00632.25 ELR11060.1 - 7.3e-68 229.3 0.0 1.3e-67 228.4 0.0 1.3 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) SPRY PF00622.28 ELR11060.1 - 2.7e-14 53.3 0.1 7.7e-14 51.8 0.1 1.8 1 0 0 1 1 1 1 SPRY domain Laminin_G_3 PF13385.6 ELR11060.1 - 7.1e-07 29.5 0.0 1.9e-06 28.1 0.0 1.6 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Actin PF00022.19 ELR11061.1 - 6.7e-29 100.7 0.0 3e-19 68.9 0.0 3.4 3 1 0 3 3 3 3 Actin Actin_micro PF17003.5 ELR11061.1 - 4.7e-10 39.2 0.5 5.2e-07 29.2 0.0 2.1 2 0 0 2 2 2 2 Putative actin-like family TPR_1 PF00515.28 ELR11062.1 - 8.2e-39 129.9 27.1 2.9e-08 33.2 0.7 9.4 9 0 0 9 9 9 6 Tetratricopeptide repeat TPR_2 PF07719.17 ELR11062.1 - 1.2e-35 118.8 31.5 7.7e-07 28.8 1.5 9.6 9 0 0 9 9 9 6 Tetratricopeptide repeat TPR_11 PF13414.6 ELR11062.1 - 2.6e-28 97.4 23.8 2.9e-06 26.8 0.4 8.6 5 2 3 8 8 8 6 TPR repeat DnaJ PF00226.31 ELR11062.1 - 9.5e-26 89.7 0.9 2.3e-25 88.5 0.9 1.7 1 0 0 1 1 1 1 DnaJ domain TPR_8 PF13181.6 ELR11062.1 - 3.8e-25 86.0 18.7 2.4e-06 27.3 0.5 8.6 8 1 1 9 9 8 6 Tetratricopeptide repeat TPR_16 PF13432.6 ELR11062.1 - 6e-23 81.2 30.6 5e-07 30.3 0.6 6.1 5 1 1 6 6 6 5 Tetratricopeptide repeat TPR_19 PF14559.6 ELR11062.1 - 1e-22 80.4 27.7 5.5e-06 26.8 0.4 8.8 5 3 5 10 10 9 7 Tetratricopeptide repeat TPR_14 PF13428.6 ELR11062.1 - 2.4e-19 68.4 29.7 0.00056 20.5 0.2 9.0 3 3 6 9 9 9 5 Tetratricopeptide repeat TPR_9 PF13371.6 ELR11062.1 - 2.2e-11 43.7 18.6 5.9e-05 23.1 5.5 4.6 4 2 1 5 5 4 2 Tetratricopeptide repeat TPR_7 PF13176.6 ELR11062.1 - 9.4e-11 41.0 18.5 0.00069 19.5 1.0 7.7 8 0 0 8 8 7 2 Tetratricopeptide repeat TPR_17 PF13431.6 ELR11062.1 - 1.5e-10 40.7 13.5 0.79 10.2 0.5 9.9 11 0 0 11 11 10 2 Tetratricopeptide repeat TPR_12 PF13424.6 ELR11062.1 - 3.5e-10 40.0 29.9 0.00039 20.7 7.3 7.0 4 3 2 6 6 6 2 Tetratricopeptide repeat TPR_6 PF13174.6 ELR11062.1 - 8e-09 35.6 25.2 0.062 14.0 1.3 8.7 9 0 0 9 9 9 3 Tetratricopeptide repeat ANAPC3 PF12895.7 ELR11062.1 - 2.4e-08 34.1 12.5 0.17 12.1 0.0 5.4 3 2 2 5 5 5 4 Anaphase-promoting complex, cyclosome, subunit 3 BTAD PF03704.17 ELR11062.1 - 0.0018 18.7 22.4 1.1 9.7 7.8 4.9 2 2 1 4 4 4 2 Bacterial transcriptional activator domain TPR_15 PF13429.6 ELR11062.1 - 0.0058 15.9 14.2 0.42 9.8 3.6 5.0 3 2 2 5 5 5 1 Tetratricopeptide repeat TPR_4 PF07721.14 ELR11062.1 - 0.0075 16.8 15.9 3 8.7 0.0 7.0 7 0 0 7 7 7 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 ELR11062.1 - 0.0083 16.2 10.7 1.3 9.2 0.3 5.6 6 2 2 8 8 7 2 Fis1 C-terminal tetratricopeptide repeat COPI_C PF06957.11 ELR11062.1 - 0.023 13.5 0.4 5.4 5.7 0.0 2.9 3 0 0 3 3 3 0 Coatomer (COPI) alpha subunit C-terminus NARP1 PF12569.8 ELR11062.1 - 0.038 12.9 13.6 0.81 8.5 0.6 3.6 2 2 1 3 3 3 0 NMDA receptor-regulated protein 1 PknG_TPR PF16918.5 ELR11062.1 - 0.042 12.6 5.5 0.19 10.5 5.5 2.1 1 1 0 1 1 1 0 Protein kinase G tetratricopeptide repeat TPR_3 PF07720.12 ELR11062.1 - 0.1 12.6 10.1 4.2 7.5 0.2 4.9 5 0 0 5 5 5 0 Tetratricopeptide repeat SHNi-TPR PF10516.9 ELR11062.1 - 0.11 12.0 3.4 17 5.0 0.0 4.3 4 0 0 4 4 4 0 SHNi-TPR TPR_10 PF13374.6 ELR11062.1 - 0.58 10.1 27.0 0.043 13.7 1.4 6.8 8 0 0 8 8 7 0 Tetratricopeptide repeat MIT PF04212.18 ELR11062.1 - 1.4 9.1 17.5 4 7.6 0.1 5.1 4 1 1 5 5 5 0 MIT (microtubule interacting and transport) domain MAS20 PF02064.15 ELR11062.1 - 1.8 8.6 11.1 9.8 6.3 0.1 4.3 2 1 2 5 5 5 0 MAS20 protein import receptor Alkyl_sulf_dimr PF14863.6 ELR11062.1 - 4.6 7.7 11.5 17 5.9 0.2 4.2 2 1 2 5 5 5 0 Alkyl sulfatase dimerisation Rad17 PF03215.15 ELR11065.1 - 0.00059 19.8 0.0 0.00067 19.6 0.0 1.1 1 0 0 1 1 1 1 Rad17 P-loop domain FtsK_SpoIIIE PF01580.18 ELR11065.1 - 0.016 14.6 0.0 0.018 14.4 0.0 1.1 1 0 0 1 1 1 0 FtsK/SpoIIIE family DUF815 PF05673.13 ELR11065.1 - 0.023 13.9 0.0 0.025 13.7 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF815) T4SS-DNA_transf PF02534.14 ELR11065.1 - 0.042 12.6 0.0 0.044 12.6 0.0 1.1 1 0 0 1 1 1 0 Type IV secretory system Conjugative DNA transfer AAA_16 PF13191.6 ELR11065.1 - 0.077 13.4 0.0 0.083 13.3 0.0 1.1 1 0 0 1 1 1 0 AAA ATPase domain Mg_chelatase PF01078.21 ELR11065.1 - 0.092 12.1 0.0 0.1 12.0 0.0 1.1 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI T2SSE PF00437.20 ELR11065.1 - 0.097 11.7 0.0 0.11 11.6 0.0 1.1 1 0 0 1 1 1 0 Type II/IV secretion system protein ABC_tran PF00005.27 ELR11065.1 - 0.21 12.1 0.0 0.26 11.8 0.0 1.2 1 0 0 1 1 1 0 ABC transporter TPR_1 PF00515.28 ELR11067.1 - 5.8e-59 193.7 23.0 2e-08 33.7 0.1 9.9 10 0 0 10 10 10 9 Tetratricopeptide repeat TPR_2 PF07719.17 ELR11067.1 - 2.7e-53 173.8 16.0 5.7e-06 26.0 1.4 10.1 10 0 0 10 10 10 9 Tetratricopeptide repeat TPR_8 PF13181.6 ELR11067.1 - 3.1e-41 136.1 17.4 0.00053 20.0 0.0 10.3 10 0 0 10 10 10 9 Tetratricopeptide repeat TPR_17 PF13431.6 ELR11067.1 - 9.8e-32 107.0 18.2 0.00067 19.9 0.1 9.4 9 0 0 9 9 9 7 Tetratricopeptide repeat TPR_12 PF13424.6 ELR11067.1 - 3.8e-29 100.8 12.4 7.6e-06 26.1 1.9 7.0 4 2 2 6 6 6 4 Tetratricopeptide repeat TPR_14 PF13428.6 ELR11067.1 - 4e-29 98.8 3.5 0.0064 17.2 0.1 9.5 3 3 7 10 10 10 7 Tetratricopeptide repeat TPR_19 PF14559.6 ELR11067.1 - 1.3e-26 92.9 8.6 5e-05 23.7 0.0 6.7 4 1 3 7 7 7 7 Tetratricopeptide repeat TPR_16 PF13432.6 ELR11067.1 - 2.4e-26 92.1 1.5 2.8e-06 27.8 0.1 6.6 2 1 6 8 8 8 7 Tetratricopeptide repeat TPR_7 PF13176.6 ELR11067.1 - 6.2e-26 88.5 8.3 0.0026 17.7 0.2 9.6 10 0 0 10 10 10 6 Tetratricopeptide repeat TPR_6 PF13174.6 ELR11067.1 - 4.1e-25 86.7 12.2 0.0034 17.9 1.9 9.5 10 0 0 10 10 10 5 Tetratricopeptide repeat TPR_11 PF13414.6 ELR11067.1 - 3.9e-23 80.8 31.4 1.9e-07 30.7 0.5 9.8 4 3 6 10 10 10 5 TPR repeat TPR_9 PF13371.6 ELR11067.1 - 4.4e-20 71.6 6.4 6.4e-05 23.0 1.0 6.4 2 2 4 7 7 7 6 Tetratricopeptide repeat ANAPC3 PF12895.7 ELR11067.1 - 6e-14 52.0 11.5 9.5e-08 32.2 0.3 4.0 3 1 1 4 4 4 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_15 PF13429.6 ELR11067.1 - 1.8e-10 40.5 4.6 6e-05 22.4 2.5 4.8 1 1 2 3 3 3 2 Tetratricopeptide repeat TPR_21 PF09976.9 ELR11067.1 - 4.4e-10 39.6 2.8 0.042 13.6 0.0 4.3 3 1 1 4 4 4 3 Tetratricopeptide repeat-like domain ChAPs PF09295.10 ELR11067.1 - 2.9e-08 33.1 0.2 0.0037 16.3 0.0 3.1 2 1 0 3 3 3 2 ChAPs (Chs5p-Arf1p-binding proteins) BTAD PF03704.17 ELR11067.1 - 2e-07 31.5 2.9 0.27 11.7 0.0 3.3 3 0 0 3 3 3 2 Bacterial transcriptional activator domain TPR_20 PF14561.6 ELR11067.1 - 1.1e-06 28.8 0.3 0.046 14.0 0.0 5.1 4 2 2 6 6 5 1 Tetratricopeptide repeat SNAP PF14938.6 ELR11067.1 - 1.2e-06 28.2 8.2 0.0029 17.1 0.6 4.0 3 2 0 3 3 3 2 Soluble NSF attachment protein, SNAP TPR_10 PF13374.6 ELR11067.1 - 7.3e-06 25.7 11.7 4.5 7.3 0.0 7.6 8 0 0 8 8 8 1 Tetratricopeptide repeat TPR_MalT PF17874.1 ELR11067.1 - 0.00017 21.1 0.5 2.7 7.3 0.0 3.7 1 1 1 3 3 3 2 MalT-like TPR region TPR_3 PF07720.12 ELR11067.1 - 0.00068 19.6 14.5 3.2 7.9 0.7 5.4 5 0 0 5 5 5 1 Tetratricopeptide repeat NARP1 PF12569.8 ELR11067.1 - 0.00072 18.6 3.9 0.91 8.4 0.6 3.9 2 2 1 4 4 4 1 NMDA receptor-regulated protein 1 Tcf25 PF04910.14 ELR11067.1 - 0.0037 16.4 0.4 0.018 14.1 0.0 2.2 3 0 0 3 3 3 1 Transcriptional repressor TCF25 DUF410 PF04190.13 ELR11067.1 - 0.017 14.9 3.6 3.5 7.3 0.3 3.0 2 1 0 2 2 2 0 Protein of unknown function (DUF410) DUF627 PF04781.12 ELR11067.1 - 0.017 15.1 0.3 6.1 6.9 0.0 3.7 3 1 0 3 3 3 0 Protein of unknown function (DUF627) DUF4919 PF16266.5 ELR11067.1 - 0.021 14.8 0.4 0.94 9.4 0.1 2.7 2 1 0 2 2 2 0 Domain of unknown function (DUF4919) Cohesin_load PF10345.9 ELR11067.1 - 0.059 11.8 2.4 7.2 4.9 0.1 3.0 2 1 1 3 3 3 0 Cohesin loading factor MIT PF04212.18 ELR11067.1 - 0.06 13.4 16.5 7.3 6.7 1.2 5.8 6 0 0 6 6 5 0 MIT (microtubule interacting and transport) domain Clathrin PF00637.20 ELR11067.1 - 0.24 11.2 3.0 2.3 8.1 0.0 3.6 2 1 0 3 3 3 0 Region in Clathrin and VPS Fis1_TPR_C PF14853.6 ELR11067.1 - 0.32 11.1 4.6 15 5.7 0.0 4.8 5 1 1 6 6 4 0 Fis1 C-terminal tetratricopeptide repeat TOM20_plant PF06552.12 ELR11067.1 - 0.58 9.9 3.7 12 5.6 0.3 4.0 3 1 0 4 4 4 0 Plant specific mitochondrial import receptor subunit TOM20 TipAS PF07739.13 ELR11067.1 - 3.4 8.2 7.5 3.5 8.2 0.5 3.9 4 1 0 4 4 4 0 TipAS antibiotic-recognition domain HARE-HTH PF05066.13 ELR11068.1 - 8.7e-11 42.1 0.0 2e-10 40.9 0.0 1.7 1 0 0 1 1 1 1 HB1, ASXL, restriction endonuclease HTH domain ORC6 PF05460.13 ELR11068.1 - 0.042 13.1 25.4 0.5 9.6 7.0 2.2 2 0 0 2 2 2 0 Origin recognition complex subunit 6 (ORC6) RNA_polI_A34 PF08208.11 ELR11068.1 - 0.25 11.4 37.6 1.3 9.1 19.9 2.3 2 0 0 2 2 2 0 DNA-directed RNA polymerase I subunit RPA34.5 CCDC53 PF10152.9 ELR11068.1 - 0.39 11.1 14.5 4.1 7.8 0.6 2.5 2 0 0 2 2 2 0 Subunit CCDC53 of WASH complex RR_TM4-6 PF06459.12 ELR11068.1 - 0.43 10.4 26.3 0.96 9.2 7.9 2.1 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 RPN2_C PF18004.1 ELR11068.1 - 2.4 8.1 29.9 0.56 10.1 8.2 2.4 2 0 0 2 2 2 0 26S proteasome regulatory subunit RPN2 C-terminal domain tRNA-synt_1c PF00749.21 ELR11069.1 - 4.1e-103 344.6 0.0 7.1e-103 343.8 0.0 1.4 2 0 0 2 2 2 1 tRNA synthetases class I (E and Q), catalytic domain SepSecS PF05889.13 ELR11070.1 - 6.2e-122 407.0 0.0 1.7e-99 333.2 0.0 2.0 1 1 1 2 2 2 2 O-phosphoseryl-tRNA(Sec) selenium transferase, SepSecS Beta_elim_lyase PF01212.21 ELR11070.1 - 0.0046 16.3 0.0 0.0076 15.6 0.0 1.4 1 0 0 1 1 1 1 Beta-eliminating lyase Fibrillin_U_N PF18193.1 ELR11070.1 - 0.025 14.7 0.1 0.24 11.5 0.0 2.2 2 0 0 2 2 2 0 Fibrillin 1 unique N-terminal domain Acyl-CoA_dh_M PF02770.19 ELR11071.1 - 5.1e-07 29.8 0.0 9.2e-07 29.0 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_1 PF00441.24 ELR11071.1 - 2.3e-06 27.9 0.2 9.3e-05 22.7 0.2 2.4 1 1 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Toxin_5 PF05294.13 ELR11071.1 - 1.3 9.5 5.2 0.19 12.2 0.9 1.8 2 0 0 2 2 2 0 Scorpion short toxin ACOX PF01756.19 ELR11072.1 - 9.9e-25 87.1 0.0 1.4e-24 86.7 0.0 1.2 1 0 0 1 1 1 1 Acyl-CoA oxidase CDC45 PF02724.14 ELR11073.1 - 0.42 8.8 3.4 0.44 8.8 3.4 1.0 1 0 0 1 1 1 0 CDC45-like protein Nop14 PF04147.12 ELR11073.1 - 5.4 5.1 11.2 5.6 5.0 11.2 1.0 1 0 0 1 1 1 0 Nop14-like family ATG27 PF09451.10 ELR11075.1 - 0.079 12.8 0.0 0.52 10.1 0.0 2.0 1 1 1 2 2 2 0 Autophagy-related protein 27 CIMR PF00878.18 ELR11075.1 - 0.12 12.5 0.0 0.23 11.5 0.0 1.4 1 0 0 1 1 1 0 Cation-independent mannose-6-phosphate receptor repeat PBP1_TM PF14812.6 ELR11075.1 - 0.43 11.0 5.0 0.96 9.9 4.4 1.9 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Nucleo_P87 PF07267.11 ELR11075.1 - 0.84 8.4 4.6 1 8.1 4.6 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 ATG27 PF09451.10 ELR11076.1 - 5.7e-19 69.0 0.0 7.8e-19 68.6 0.0 1.1 1 0 0 1 1 1 1 Autophagy-related protein 27 CIMR PF00878.18 ELR11076.1 - 1.9e-08 34.5 0.1 0.0005 20.2 0.2 2.1 2 0 0 2 2 2 2 Cation-independent mannose-6-phosphate receptor repeat Man-6-P_recep PF02157.15 ELR11076.1 - 1.8e-06 27.3 1.6 2.4e-06 26.9 0.4 1.7 2 1 0 2 2 2 1 Mannose-6-phosphate receptor Na_Ca_ex PF01699.24 ELR11078.1 - 3.3e-16 59.6 20.0 5.1e-16 59.0 19.4 1.5 2 0 0 2 2 2 1 Sodium/calcium exchanger protein ATP-synt_8 PF00895.20 ELR11078.1 - 0.3 11.6 8.6 4.7 7.8 0.0 3.6 4 0 0 4 4 4 0 ATP synthase protein 8 Methyltransf_22 PF13383.6 ELR11079.1 - 1.6e-09 37.7 0.0 0.00014 21.6 0.0 2.1 1 1 1 2 2 2 2 Methyltransferase domain Methyltransf_21 PF05050.12 ELR11079.1 - 0.022 14.8 0.1 0.038 14.0 0.1 1.5 1 0 0 1 1 1 0 Methyltransferase FkbM domain DUF3368 PF11848.8 ELR11079.1 - 0.077 12.8 0.0 4.4 7.2 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF3368) Adap_comp_sub PF00928.21 ELR11080.1 - 6.3e-37 127.4 0.0 7e-37 127.2 0.0 1.0 1 0 0 1 1 1 1 Adaptor complexes medium subunit family IBV_3C PF03620.13 ELR11080.1 - 0.099 13.1 0.0 0.18 12.3 0.0 1.4 1 0 0 1 1 1 0 IBV 3C protein F-box-like PF12937.7 ELR11081.1 - 4.8e-07 29.6 0.2 1e-06 28.5 0.2 1.7 1 0 0 1 1 1 1 F-box-like RsgA_GTPase PF03193.16 ELR11081.1 - 0.0023 17.9 0.0 0.0034 17.3 0.0 1.2 1 0 0 1 1 1 1 RsgA GTPase G-alpha PF00503.20 ELR11081.1 - 0.018 14.2 0.0 0.023 13.8 0.0 1.1 1 0 0 1 1 1 0 G-protein alpha subunit AAA_29 PF13555.6 ELR11081.1 - 0.026 14.2 0.0 0.053 13.3 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain ABC_tran PF00005.27 ELR11081.1 - 0.17 12.4 0.0 0.27 11.8 0.0 1.3 1 0 0 1 1 1 0 ABC transporter Adap_comp_sub PF00928.21 ELR11082.1 - 1.1e-07 31.5 0.0 1.6e-07 31.0 0.0 1.3 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 ELR11082.1 - 1.1e-06 28.6 0.2 1.5e-06 28.2 0.2 1.2 1 0 0 1 1 1 1 Clathrin adaptor complex small chain Trp_ring PF18669.1 ELR11082.1 - 0.19 11.9 0.4 2.9 8.1 0.1 2.3 2 0 0 2 2 2 0 Trimeric autotransporter adhesin Trp ring domain F-box-like PF12937.7 ELR11084.1 - 0.013 15.4 0.1 0.064 13.2 0.0 2.1 2 0 0 2 2 2 0 F-box-like WD40 PF00400.32 ELR11085.1 - 7.1e-20 71.0 11.5 1.9e-10 41.2 0.7 4.0 4 0 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ELR11085.1 - 0.00049 20.3 0.2 0.45 10.8 0.0 2.9 1 1 1 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain Prominin PF05478.11 ELR11086.1 - 0.012 13.6 3.8 0.016 13.2 3.8 1.1 1 0 0 1 1 1 0 Prominin Phage_B PF02304.15 ELR11086.1 - 0.03 14.7 1.2 0.048 14.0 0.1 1.8 2 0 0 2 2 2 0 Scaffold protein B MLANA PF14991.6 ELR11086.1 - 0.035 14.4 0.2 0.089 13.1 0.1 1.7 2 0 0 2 2 2 0 Protein melan-A EphA2_TM PF14575.6 ELR11086.1 - 0.054 14.4 0.0 0.14 13.0 0.0 1.7 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain TMEM52 PF14979.6 ELR11086.1 - 0.75 9.7 7.4 1.6 8.7 7.4 1.5 1 0 0 1 1 1 0 Transmembrane 52 ETRAMP PF09716.10 ELR11086.1 - 0.76 9.9 3.3 3.8 7.6 0.5 2.3 1 1 1 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) DUF4713 PF15831.5 ELR11086.1 - 2.1 8.8 15.2 4.8 7.7 15.2 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4713) Podoplanin PF05808.11 ELR11087.1 - 0.0053 16.9 0.1 0.01 16.0 0.1 1.4 1 0 0 1 1 1 1 Podoplanin Mucin PF01456.17 ELR11087.1 - 0.055 13.5 0.0 0.084 12.9 0.0 1.3 1 0 0 1 1 1 0 Mucin-like glycoprotein EFG_IV PF03764.18 ELR11088.1 - 3.2e-09 36.6 0.0 3.8e-09 36.4 0.0 1.2 1 0 0 1 1 1 1 Elongation factor G, domain IV Ribosomal_L32e PF01655.18 ELR11089.1 - 1.8e-49 166.7 1.6 2.1e-49 166.4 1.6 1.1 1 0 0 1 1 1 1 Ribosomal protein L32 Pkinase_Tyr PF07714.17 ELR11090.1 - 2.6e-64 217.0 0.0 3.3e-64 216.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ELR11090.1 - 3.2e-57 193.9 0.0 4.4e-57 193.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.23 ELR11090.1 - 1.3e-05 25.2 0.1 3.5e-05 23.9 0.1 1.6 1 1 0 1 1 1 1 Phosphotransferase enzyme family Guanylate_cyc PF00211.20 ELR11090.1 - 0.00051 19.7 0.0 0.00077 19.1 0.0 1.3 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain Haspin_kinase PF12330.8 ELR11090.1 - 0.0013 17.7 0.1 0.0027 16.7 0.1 1.6 1 1 0 1 1 1 1 Haspin like kinase domain Pkinase_fungal PF17667.1 ELR11090.1 - 0.03 13.1 0.0 0.045 12.5 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase Seadorna_VP7 PF07387.11 ELR11090.1 - 0.095 11.7 0.0 0.17 10.9 0.0 1.3 1 0 0 1 1 1 0 Seadornavirus VP7 Kinase-like PF14531.6 ELR11090.1 - 0.14 11.5 0.0 0.66 9.2 0.0 1.9 2 0 0 2 2 2 0 Kinase-like YukC PF10140.9 ELR11090.1 - 0.25 10.1 0.0 0.37 9.6 0.0 1.1 1 0 0 1 1 1 0 WXG100 protein secretion system (Wss), protein YukC ANT PF03374.14 ELR11091.1 - 0.082 13.2 0.1 0.12 12.7 0.1 1.3 1 0 0 1 1 1 0 Phage antirepressor protein KilAC domain Pkinase_Tyr PF07714.17 ELR11092.1 - 3.8e-08 32.9 0.5 3.2e-05 23.4 0.1 2.0 1 1 1 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 ELR11092.1 - 4.9e-05 22.8 0.1 0.00019 20.9 0.0 1.5 1 1 1 2 2 2 1 Protein kinase domain DUF4417 PF14386.6 ELR11092.1 - 0.15 11.7 0.0 0.18 11.4 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4417) SWIB PF02201.18 ELR11094.1 - 4.2e-21 74.6 0.0 1.3e-20 73.0 0.0 1.9 2 0 0 2 2 2 1 SWIB/MDM2 domain YebG PF07130.12 ELR11094.1 - 0.044 13.6 0.1 0.32 10.9 0.0 2.2 2 0 0 2 2 2 0 YebG protein WD40 PF00400.32 ELR11095.1 - 7.2e-06 26.6 1.0 0.02 15.8 0.1 2.2 2 0 0 2 2 2 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ELR11095.1 - 0.02 15.2 0.0 0.069 13.5 0.0 1.7 1 1 1 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain PQQ_3 PF13570.6 ELR11095.1 - 0.1 13.1 0.0 1.8 9.1 0.0 2.1 2 0 0 2 2 2 0 PQQ-like domain NAD_binding_8 PF13450.6 ELR11096.1 - 7.9e-12 45.2 0.1 1.1e-11 44.8 0.1 1.3 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Amino_oxidase PF01593.24 ELR11096.1 - 3e-09 36.7 0.0 3.4e-09 36.5 0.0 1.0 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase Thi4 PF01946.17 ELR11096.1 - 1.2e-08 34.6 0.0 1.6e-08 34.1 0.0 1.1 1 0 0 1 1 1 1 Thi4 family FAD_binding_2 PF00890.24 ELR11096.1 - 2.5e-07 30.2 0.1 2.7e-07 30.0 0.1 1.1 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.24 ELR11096.1 - 8.6e-06 25.6 0.1 9.7e-06 25.4 0.1 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase Lycopene_cycl PF05834.12 ELR11096.1 - 9.1e-05 21.7 0.1 0.00012 21.3 0.1 1.1 1 0 0 1 1 1 1 Lycopene cyclase protein FAD_oxidored PF12831.7 ELR11096.1 - 0.00031 20.2 0.0 0.00035 20.1 0.0 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_3 PF01494.19 ELR11096.1 - 0.00071 18.9 0.0 0.00088 18.6 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain NAD_binding_9 PF13454.6 ELR11096.1 - 0.001 19.1 0.0 0.0012 18.8 0.0 1.2 1 0 0 1 1 1 1 FAD-NAD(P)-binding Pyr_redox_2 PF07992.14 ELR11096.1 - 0.0015 17.8 0.1 0.0019 17.5 0.1 1.3 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 ELR11096.1 - 0.0046 15.7 0.0 0.0078 15.0 0.0 1.3 2 0 0 2 2 2 1 HI0933-like protein GIDA PF01134.22 ELR11096.1 - 0.0061 15.7 0.0 0.0068 15.5 0.0 1.1 1 0 0 1 1 1 1 Glucose inhibited division protein A GDI PF00996.18 ELR11096.1 - 0.0082 14.7 0.0 0.0098 14.5 0.0 1.1 1 0 0 1 1 1 1 GDP dissociation inhibitor MCRA PF06100.11 ELR11096.1 - 0.03 13.1 0.0 0.033 13.0 0.0 1.1 1 0 0 1 1 1 0 MCRA family G3P_acyltransf PF02660.15 ELR11096.1 - 0.08 13.0 0.0 0.097 12.7 0.0 1.2 1 0 0 1 1 1 0 Glycerol-3-phosphate acyltransferase V4R PF02830.18 ELR11097.1 - 7.5e-07 29.1 0.5 0.0023 17.9 0.1 2.5 2 0 0 2 2 2 2 V4R domain PfkB PF00294.24 ELR11098.1 - 1.5e-43 149.2 2.0 1.9e-43 148.9 2.0 1.0 1 0 0 1 1 1 1 pfkB family carbohydrate kinase DUF2877 PF11392.8 ELR11098.1 - 0.039 14.7 0.0 16 6.3 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2877) RhoGAP PF00620.27 ELR11099.1 - 6.5e-15 55.3 0.0 9.7e-15 54.7 0.0 1.2 1 0 0 1 1 1 1 RhoGAP domain DNA_pol_A_exo1 PF01612.20 ELR11100.1 - 2.5e-16 59.9 0.0 4.6e-16 59.0 0.0 1.4 1 0 0 1 1 1 1 3'-5' exonuclease Ax_dynein_light PF10211.9 ELR11100.1 - 0.0092 15.9 2.2 0.014 15.3 2.2 1.5 1 0 0 1 1 1 1 Axonemal dynein light chain CENP-H PF05837.12 ELR11100.1 - 0.011 16.1 4.7 0.021 15.2 4.7 1.5 1 0 0 1 1 1 0 Centromere protein H (CENP-H) OmpH PF03938.14 ELR11100.1 - 0.021 15.2 5.0 0.032 14.6 5.0 1.4 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) ATG16 PF08614.11 ELR11100.1 - 0.077 13.2 8.9 0.51 10.5 8.9 2.0 1 1 0 1 1 1 0 Autophagy protein 16 (ATG16) UPF0242 PF06785.11 ELR11100.1 - 0.1 12.7 1.0 0.15 12.1 1.0 1.4 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Hydantoinase_B PF02538.14 ELR11100.1 - 0.18 10.2 2.7 0.21 9.9 2.7 1.1 1 0 0 1 1 1 0 Hydantoinase B/oxoprolinase APG6_N PF17675.1 ELR11100.1 - 0.18 12.3 8.9 0.41 11.2 8.9 1.7 1 1 0 1 1 1 0 Apg6 coiled-coil region BBP1_C PF15272.6 ELR11100.1 - 0.2 11.5 0.9 0.31 10.8 0.9 1.3 1 0 0 1 1 1 0 Spindle pole body component BBP1, C-terminal GAS PF13851.6 ELR11100.1 - 0.23 10.8 3.8 0.36 10.2 3.8 1.2 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding Flot PF15975.5 ELR11100.1 - 0.25 11.6 13.9 0.7 10.1 13.9 1.9 1 0 0 1 1 1 0 Flotillin DUF4472 PF14739.6 ELR11100.1 - 0.27 12.0 3.9 0.49 11.2 3.0 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4472) Uso1_p115_C PF04871.13 ELR11100.1 - 0.77 10.1 5.4 1.4 9.3 5.4 1.5 1 0 0 1 1 1 0 Uso1 / p115 like vesicle tethering protein, C terminal region ZapB PF06005.12 ELR11100.1 - 1.7 9.1 7.5 7.4 7.1 7.5 2.1 1 1 0 1 1 1 0 Cell division protein ZapB Tetraspanin PF00335.20 ELR11101.1 - 0.00022 21.0 9.3 0.00034 20.4 9.3 1.2 1 0 0 1 1 1 1 Tetraspanin family Beta-APP PF03494.13 ELR11101.1 - 0.92 9.4 7.7 1.6 8.6 7.7 1.4 1 0 0 1 1 1 0 Beta-amyloid peptide (beta-APP) DUF4342 PF14242.6 ELR11101.1 - 0.97 9.5 4.5 1.7 8.7 0.5 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4342) Ank_4 PF13637.6 ELR11103.1 - 2.3e-09 37.6 2.0 0.54 10.9 0.0 7.4 3 2 5 8 8 8 5 Ankyrin repeats (many copies) Ank_2 PF12796.7 ELR11103.1 - 1.2e-07 32.2 0.2 0.0038 17.8 0.0 3.7 3 0 0 3 3 3 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 ELR11103.1 - 1.8e-06 28.1 7.6 7.1 7.1 0.0 7.4 7 1 1 8 8 8 3 Ankyrin repeats (many copies) F-box PF00646.33 ELR11103.1 - 0.00064 19.5 0.3 0.0013 18.6 0.3 1.4 1 0 0 1 1 1 1 F-box domain CXCXC PF03128.14 ELR11103.1 - 1.1 9.9 5.4 82 4.0 0.1 4.8 5 0 0 5 5 5 0 CXCXC repeat TALPID3 PF15324.6 ELR11104.1 - 0.64 7.6 1.5 0.76 7.4 1.5 1.0 1 0 0 1 1 1 0 Hedgehog signalling target UBX PF00789.20 ELR11105.1 - 1.6e-06 28.2 0.0 2.8e-06 27.4 0.0 1.3 1 0 0 1 1 1 1 UBX domain PBP1_TM PF14812.6 ELR11106.1 - 0.029 14.7 1.8 0.029 14.7 1.8 4.8 4 2 0 4 4 4 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Menin PF05053.13 ELR11106.1 - 7 4.9 11.9 11 4.2 11.9 1.3 1 0 0 1 1 1 0 Menin LRR_8 PF13855.6 ELR11108.1 - 3.8e-13 49.0 9.3 5.3e-09 35.7 3.2 3.2 4 0 0 4 4 4 2 Leucine rich repeat LRR_4 PF12799.7 ELR11108.1 - 8.3e-12 45.1 23.1 7.5e-06 26.2 3.3 4.9 3 2 2 5 5 5 4 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 ELR11108.1 - 5.4e-07 29.3 6.7 2.7e-06 27.0 1.0 2.8 2 1 1 3 3 3 2 Leucine-rich repeat LRR_6 PF13516.6 ELR11108.1 - 0.25 11.5 0.1 0.25 11.5 0.1 4.1 5 0 0 5 5 5 0 Leucine Rich repeat LRR_1 PF00560.33 ELR11108.1 - 2.9 8.8 10.6 13 6.8 0.1 4.8 5 1 0 5 5 5 0 Leucine Rich Repeat WD40 PF00400.32 ELR11109.1 - 0.00063 20.5 0.0 0.015 16.2 0.0 2.2 2 0 0 2 2 2 1 WD domain, G-beta repeat F-box-like PF12937.7 ELR11111.1 - 0.00012 21.8 1.0 0.00012 21.8 1.0 2.9 2 1 1 3 3 3 1 F-box-like Tubulin PF00091.25 ELR11111.1 - 0.0024 18.1 0.0 0.003 17.8 0.0 1.1 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain F-box PF00646.33 ELR11111.1 - 0.14 12.0 0.4 0.6 10.1 0.4 1.9 1 1 0 1 1 1 0 F-box domain VWA PF00092.28 ELR11114.1 - 2.1e-20 73.7 0.0 3.8e-20 72.8 0.0 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.6 ELR11114.1 - 8e-14 52.2 0.1 2.8e-13 50.4 0.0 2.0 2 0 0 2 2 2 1 von Willebrand factor type A domain RsgA_GTPase PF03193.16 ELR11114.1 - 0.00062 19.7 0.8 0.017 15.0 0.0 2.4 2 0 0 2 2 2 1 RsgA GTPase VWA_CoxE PF05762.14 ELR11114.1 - 0.00091 18.7 0.2 0.0017 17.8 0.2 1.3 1 0 0 1 1 1 1 VWA domain containing CoxE-like protein MMR_HSR1 PF01926.23 ELR11114.1 - 0.017 15.2 0.0 0.053 13.6 0.0 2.0 2 0 0 2 2 2 0 50S ribosome-binding GTPase AAA_22 PF13401.6 ELR11114.1 - 0.049 13.9 0.0 88 3.4 0.0 3.7 3 0 0 3 3 3 0 AAA domain DUF815 PF05673.13 ELR11114.1 - 0.061 12.5 0.0 0.11 11.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) DUF11 PF01345.18 ELR11114.1 - 0.072 13.4 0.1 0.51 10.7 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function DUF11 Septin PF00735.18 ELR11114.1 - 0.38 10.0 2.8 6.9 5.9 0.4 2.2 2 0 0 2 2 2 0 Septin ABC_membrane PF00664.23 ELR11116.1 - 1.8e-55 188.5 11.9 2.6e-55 188.0 11.9 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 ELR11116.1 - 2.2e-16 60.6 0.0 4.8e-16 59.5 0.0 1.6 1 0 0 1 1 1 1 ABC transporter RsgA_GTPase PF03193.16 ELR11116.1 - 0.039 13.8 0.0 0.075 12.9 0.0 1.4 1 0 0 1 1 1 0 RsgA GTPase AAA_29 PF13555.6 ELR11116.1 - 0.051 13.3 0.1 0.13 12.0 0.1 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain APS_kinase PF01583.20 ELR11116.1 - 0.11 12.4 0.0 0.32 10.9 0.0 1.8 2 0 0 2 2 2 0 Adenylylsulphate kinase AAA_PrkA PF08298.11 ELR11116.1 - 0.13 11.2 0.1 0.21 10.5 0.1 1.2 1 0 0 1 1 1 0 PrkA AAA domain AAA_22 PF13401.6 ELR11116.1 - 0.15 12.3 0.0 0.33 11.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain DUF4191 PF13829.6 ELR11116.1 - 1.1 8.5 7.4 0.55 9.5 3.8 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4191) Fer2_3 PF13085.6 ELR11117.1 - 5.5e-30 103.6 0.1 9.1e-30 102.9 0.1 1.4 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain Fer4_17 PF13534.6 ELR11117.1 - 0.00015 22.2 2.2 0.00015 22.2 2.2 2.5 2 0 0 2 2 2 1 4Fe-4S dicluster domain Fer4_10 PF13237.6 ELR11117.1 - 0.00062 19.8 1.0 0.00062 19.8 1.0 2.6 2 1 0 2 2 2 1 4Fe-4S dicluster domain Fer4_8 PF13183.6 ELR11117.1 - 0.0012 19.2 6.5 0.0012 19.2 6.5 3.0 1 1 2 3 3 3 2 4Fe-4S dicluster domain Fer2 PF00111.27 ELR11117.1 - 0.0051 16.7 0.4 0.0051 16.7 0.4 2.4 3 0 0 3 3 3 1 2Fe-2S iron-sulfur cluster binding domain Fer4_18 PF13746.6 ELR11117.1 - 0.025 14.7 0.3 0.025 14.7 0.3 2.1 3 0 0 3 3 3 0 4Fe-4S dicluster domain ADH_N_2 PF16884.5 ELR11118.1 - 2.4e-28 98.2 1.1 3.5e-28 97.7 0.1 1.8 3 0 0 3 3 3 1 N-terminal domain of oxidoreductase ADH_zinc_N PF00107.26 ELR11118.1 - 1.5e-18 67.0 0.0 2.8e-18 66.1 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 ELR11118.1 - 1.5e-09 39.0 0.0 3.1e-09 38.0 0.0 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ELFV_dehydrog PF00208.21 ELR11118.1 - 0.016 14.9 0.1 0.034 13.9 0.1 1.5 1 0 0 1 1 1 0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase LktC PF06261.11 ELR11118.1 - 0.02 14.8 0.0 0.041 13.8 0.0 1.5 1 0 0 1 1 1 0 Actinobacillus actinomycetemcomitans leukotoxin activator LktC DUF89 PF01937.19 ELR11118.1 - 0.23 10.4 0.0 0.36 9.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function DUF89 UPF0061 PF02696.14 ELR11120.1 - 1.5e-88 297.7 0.4 4.3e-88 296.1 0.4 1.7 1 1 0 1 1 1 1 Uncharacterized ACR, YdiU/UPF0061 family NYAP_C PF15452.6 ELR11120.1 - 0.1 12.5 0.0 0.16 11.8 0.0 1.3 1 0 0 1 1 1 0 Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter Rap_GAP PF02145.15 ELR11121.1 - 2.9e-63 212.8 0.0 3.7e-63 212.4 0.0 1.1 1 0 0 1 1 1 1 Rap/ran-GAP DUF1659 PF07872.11 ELR11121.1 - 0.032 13.9 1.0 0.98 9.1 0.1 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF1659) ADP_ribosyl_GH PF03747.14 ELR11124.1 - 3.9e-26 92.5 1.4 4.7e-26 92.2 1.4 1.1 1 0 0 1 1 1 1 ADP-ribosylglycohydrolase Swi5 PF07061.11 ELR11125.1 - 4.6e-12 45.8 1.6 5.2e-12 45.7 0.2 1.8 2 0 0 2 2 2 1 Swi5 LZ3wCH PF18517.1 ELR11125.1 - 0.055 13.6 0.0 0.097 12.8 0.0 1.3 1 0 0 1 1 1 0 Leucine zipper with capping helix domain EMC1_C PF07774.13 ELR11126.1 - 6.5e-65 218.8 0.0 1.7e-64 217.4 0.0 1.8 1 0 0 1 1 1 1 ER membrane protein complex subunit 1, C-terminal PQQ_2 PF13360.6 ELR11126.1 - 8e-10 38.7 5.3 0.00052 19.7 0.1 4.0 2 2 1 4 4 4 3 PQQ-like domain PQQ PF01011.21 ELR11126.1 - 0.02 14.8 4.0 1.5 8.9 0.0 4.9 6 0 0 6 6 6 0 PQQ enzyme repeat VCBS PF13517.6 ELR11126.1 - 0.22 12.2 3.2 1.5 9.5 0.1 3.4 3 0 0 3 3 3 0 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella BTB PF00651.31 ELR11127.1 - 4.2e-15 56.0 0.0 5.7e-07 29.8 0.0 3.3 4 0 0 4 4 4 2 BTB/POZ domain BACK PF07707.15 ELR11127.1 - 7.1e-06 26.1 0.4 0.31 11.2 0.1 3.5 4 0 0 4 4 4 2 BTB And C-terminal Kelch DUF1664 PF07889.12 ELR11128.1 - 0.0076 16.3 17.2 0.064 13.3 2.7 2.4 2 0 0 2 2 2 2 Protein of unknown function (DUF1664) MCPsignal PF00015.21 ELR11128.1 - 0.011 15.5 8.6 0.011 15.5 8.6 2.2 1 1 1 2 2 2 0 Methyl-accepting chemotaxis protein (MCP) signalling domain End3 PF12761.7 ELR11128.1 - 0.014 15.6 16.0 0.014 15.6 16.0 2.5 1 1 1 2 2 1 0 Actin cytoskeleton-regulatory complex protein END3 ATG16 PF08614.11 ELR11128.1 - 0.015 15.5 23.3 0.015 15.5 23.3 2.5 1 1 1 2 2 1 0 Autophagy protein 16 (ATG16) NAD_binding_5 PF07994.12 ELR11128.1 - 0.097 12.0 6.1 0.07 12.5 4.0 1.7 1 1 0 1 1 1 0 Myo-inositol-1-phosphate synthase DUF3584 PF12128.8 ELR11128.1 - 0.1 10.1 34.3 0.12 9.8 34.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) AAA_13 PF13166.6 ELR11128.1 - 0.19 10.3 34.3 0.056 12.1 31.6 1.5 1 1 0 1 1 1 0 AAA domain DUF948 PF06103.11 ELR11128.1 - 0.29 11.4 8.7 2.5 8.4 2.2 2.5 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) NPV_P10 PF05531.12 ELR11128.1 - 1.7 9.1 8.2 0.64 10.5 0.3 3.0 2 1 0 3 3 3 0 Nucleopolyhedrovirus P10 protein KELK PF15796.5 ELR11128.1 - 1.7 9.1 39.1 1.1 9.7 12.2 2.9 2 0 0 2 2 2 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase KxDL PF10241.9 ELR11128.1 - 1.9 8.8 21.1 0.034 14.4 6.9 3.0 2 1 0 2 2 2 0 Uncharacterized conserved protein HA PF03457.14 ELR11129.1 - 1.4e-29 102.2 6.4 8.5e-16 58.0 0.9 2.5 2 0 0 2 2 2 2 Helicase associated domain Sporozoite_P67 PF05642.11 ELR11129.1 - 6.1 4.8 16.7 1 7.4 12.5 1.8 2 0 0 2 2 2 0 Sporozoite P67 surface antigen GREB1 PF15782.5 ELR11129.1 - 8.9 3.3 5.5 11 3.0 5.5 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer NapD PF03927.13 ELR11130.1 - 0.36 10.9 5.7 2.5 8.2 0.9 4.8 2 0 0 2 2 2 0 NapD protein DUF4350 PF14258.6 ELR11130.1 - 5.2 7.6 7.1 1.8e+02 2.6 0.1 5.3 4 0 0 4 4 4 0 Domain of unknown function (DUF4350) PRKG1_interact PF15898.5 ELR11131.1 - 0.0034 18.3 3.0 0.0034 18.3 3.0 17.0 6 4 13 19 19 19 3 cGMP-dependent protein kinase interacting domain Arabinose_Iso_C PF11762.8 ELR11131.1 - 0.072 12.9 0.0 0.18 11.6 0.0 1.6 1 0 0 1 1 1 0 L-arabinose isomerase C-terminal domain MORN PF02493.20 ELR11132.1 - 6.2e-36 120.2 56.7 9.2e-09 34.7 3.2 8.0 8 0 0 8 8 8 7 MORN repeat F-box-like PF12937.7 ELR11132.1 - 4.1e-08 33.0 2.0 7.1e-08 32.2 2.0 1.4 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ELR11132.1 - 8.1e-06 25.6 0.0 1.4e-05 24.8 0.0 1.4 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 ELR11133.1 - 3.1e-08 33.4 2.0 4.8e-08 32.8 2.0 1.3 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ELR11133.1 - 4e-06 26.6 0.1 7.7e-06 25.7 0.0 1.5 1 1 0 1 1 1 1 F-box domain Cwf_Cwc_15 PF04889.12 ELR11134.1 - 0.017 14.9 3.6 0.02 14.7 3.6 1.1 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein PRKG1_interact PF15898.5 ELR11134.1 - 0.029 15.3 3.9 0.046 14.6 2.8 1.9 1 1 0 1 1 1 0 cGMP-dependent protein kinase interacting domain Cytokin_check_N PF10407.9 ELR11136.1 - 2.1e-05 24.4 0.0 3.5e-05 23.7 0.0 1.3 1 0 0 1 1 1 1 Cdc14 phosphatase binding protein N-terminus Crust_neuro_H PF03858.13 ELR11137.1 - 0.029 15.1 0.0 0.064 14.1 0.0 1.6 2 0 0 2 2 2 0 Crustacean neurohormone H DUF3847 PF12958.7 ELR11137.1 - 3.4 7.9 9.3 5.2 7.3 9.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3847) Response_reg PF00072.24 ELR11138.1 - 9.9e-17 61.1 0.2 3.9e-15 56.0 0.1 2.7 2 1 0 2 2 2 1 Response regulator receiver domain LRR_4 PF12799.7 ELR11139.1 - 0.0004 20.7 0.0 0.015 15.7 0.0 2.4 2 0 0 2 2 2 1 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 ELR11139.1 - 0.0094 15.7 0.0 0.057 13.2 0.0 2.2 2 0 0 2 2 2 1 Leucine rich repeat Vps39_1 PF10366.9 ELR11140.1 - 0.0075 16.5 0.1 6.5 7.1 0.0 2.3 2 0 0 2 2 2 2 Vacuolar sorting protein 39 domain 1 LRR_4 PF12799.7 ELR11140.1 - 0.018 15.5 0.8 0.46 11.0 0.1 3.1 2 1 0 2 2 2 0 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 ELR11140.1 - 0.11 12.6 0.1 0.94 9.7 0.0 2.8 2 0 0 2 2 2 0 Leucine Rich repeat Dermcidin PF15291.6 ELR11140.1 - 0.14 12.8 0.1 26 5.4 0.0 2.3 2 0 0 2 2 2 0 Dermcidin, antibiotic peptide LRR_8 PF13855.6 ELR11140.1 - 0.14 12.0 2.6 0.63 9.8 0.5 3.1 2 1 0 2 2 2 0 Leucine rich repeat BTB PF00651.31 ELR11141.1 - 3.2e-33 114.3 0.0 1.8e-21 76.5 0.1 2.5 2 0 0 2 2 2 2 BTB/POZ domain ubiquitin PF00240.23 ELR11141.1 - 4.3e-23 80.8 0.0 1.9e-21 75.5 0.0 2.5 2 0 0 2 2 2 1 Ubiquitin family Rad60-SLD PF11976.8 ELR11141.1 - 9.2e-09 35.0 0.0 1.7e-08 34.1 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Tetraspanin PF00335.20 ELR11141.1 - 0.0044 16.8 3.0 0.0075 16.0 3.0 1.3 1 0 0 1 1 1 1 Tetraspanin family Ubiquitin_2 PF14560.6 ELR11141.1 - 0.01 16.3 0.0 0.081 13.4 0.0 2.4 2 1 0 2 2 2 0 Ubiquitin-like domain Usp PF00582.26 ELR11142.1 - 1.5e-08 35.3 0.2 3.2e-08 34.2 0.0 1.6 2 0 0 2 2 2 1 Universal stress protein family Spt5_N PF11942.8 ELR11142.1 - 0.36 11.8 4.0 27 5.8 2.5 2.3 2 0 0 2 2 2 0 Spt5 transcription elongation factor, acidic N-terminal EF-hand_7 PF13499.6 ELR11143.1 - 3.9e-13 49.7 1.7 1.3e-12 48.0 0.6 2.2 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_1 PF00036.32 ELR11143.1 - 1.4e-12 46.2 2.2 3.9e-05 22.9 0.5 2.6 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 ELR11143.1 - 1.7e-10 39.9 3.9 3.4e-05 23.4 0.5 2.9 3 0 0 3 3 3 2 EF-hand domain EF-hand_8 PF13833.6 ELR11143.1 - 4.1e-10 39.4 2.4 3e-06 27.0 1.0 2.6 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 ELR11143.1 - 1.5e-09 36.9 1.2 4.8e-05 22.7 0.2 2.6 2 0 0 2 2 2 2 EF hand SPARC_Ca_bdg PF10591.9 ELR11143.1 - 0.14 12.5 0.7 0.37 11.1 0.0 1.9 2 0 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region adh_short PF00106.25 ELR11144.1 - 3.1e-43 147.5 0.1 3.3e-28 98.5 0.0 3.5 1 1 3 4 4 4 3 short chain dehydrogenase adh_short_C2 PF13561.6 ELR11144.1 - 5.1e-27 94.9 0.0 1.6e-17 63.8 0.0 3.2 3 0 0 3 3 3 3 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ELR11144.1 - 4.3e-09 36.5 0.1 5.4e-08 33.0 0.0 2.5 2 1 0 2 2 2 1 KR domain PALP PF00291.25 ELR11144.1 - 0.00032 20.2 0.1 0.0022 17.4 0.0 2.2 3 0 0 3 3 3 1 Pyridoxal-phosphate dependent enzyme Glyco_transf_4 PF13439.6 ELR11144.1 - 0.012 15.7 0.1 34 4.4 0.1 3.8 3 1 0 3 3 3 0 Glycosyltransferase Family 4 YjeF_N PF03853.15 ELR11144.1 - 0.026 14.4 0.1 0.86 9.5 0.0 2.4 2 0 0 2 2 2 0 YjeF-related protein N-terminus Epimerase PF01370.21 ELR11144.1 - 0.2 11.1 0.8 0.46 9.9 0.0 2.1 3 1 0 3 3 3 0 NAD dependent epimerase/dehydratase family DUF2802 PF10975.8 ELR11144.1 - 2.4 8.4 4.7 33 4.7 0.1 3.7 4 0 0 4 4 4 0 Protein of unknown function (DUF2802) ACOX PF01756.19 ELR11145.1 - 1.4e-07 31.3 0.7 6.1e-07 29.2 0.7 1.9 1 1 0 1 1 1 1 Acyl-CoA oxidase Acyl-CoA_dh_M PF02770.19 ELR11145.1 - 3.1e-05 24.1 0.0 0.00013 22.1 0.0 2.0 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_1 PF00441.24 ELR11145.1 - 0.0011 19.2 0.9 0.0091 16.2 0.9 2.3 1 1 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.16 ELR11145.1 - 0.13 13.0 0.0 0.34 11.6 0.0 1.7 1 0 0 1 1 1 0 Acyl-CoA dehydrogenase, N-terminal domain HSP70 PF00012.20 ELR11146.1 - 8.6e-262 869.7 5.5 9.9e-262 869.5 5.5 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 ELR11146.1 - 6.1e-15 54.9 0.4 4.1e-14 52.1 0.1 2.0 2 0 0 2 2 2 1 MreB/Mbl protein FGGY_C PF02782.16 ELR11146.1 - 0.0023 17.7 0.0 0.0051 16.5 0.0 1.5 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain FtsA PF14450.6 ELR11146.1 - 0.0036 17.7 3.4 2.8 8.4 0.0 3.6 3 1 0 3 3 3 1 Cell division protein FtsA Hydantoinase_A PF01968.18 ELR11146.1 - 0.016 14.4 0.1 0.046 13.0 0.1 1.8 1 0 0 1 1 1 0 Hydantoinase/oxoprolinase DDR PF08841.10 ELR11146.1 - 0.067 12.2 2.8 2 7.4 0.1 2.5 3 0 0 3 3 3 0 Diol dehydratase reactivase ATPase-like domain Ppx-GppA PF02541.16 ELR11146.1 - 0.18 11.2 1.2 0.5 9.7 0.1 2.1 2 0 0 2 2 2 0 Ppx/GppA phosphatase family DUF3813 PF12758.7 ELR11146.1 - 1 9.8 4.2 19 5.7 0.1 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3813) RD3 PF14473.6 ELR11146.1 - 1.9 8.4 5.9 13 5.6 0.3 2.7 1 1 1 2 2 2 0 RD3 protein GRP PF07172.11 ELR11146.1 - 4.9 7.9 13.8 0.13 13.0 7.2 1.8 2 0 0 2 2 2 0 Glycine rich protein family Trypsin_2 PF13365.6 ELR11147.1 - 0.004 18.1 0.0 0.0063 17.4 0.0 1.4 1 0 0 1 1 1 1 Trypsin-like peptidase domain SprT-like PF10263.9 ELR11148.1 - 8.6e-20 70.7 0.0 2.2e-19 69.4 0.0 1.7 1 0 0 1 1 1 1 SprT-like family Zn_ribbon_SprT PF17283.2 ELR11148.1 - 0.0076 16.1 3.8 0.02 14.8 3.8 1.7 1 0 0 1 1 1 1 SprT-like zinc ribbon domain Zn-ribbon_8 PF09723.10 ELR11148.1 - 0.0081 16.3 0.9 0.023 14.8 0.9 1.8 1 0 0 1 1 1 1 Zinc ribbon domain zinc_ribbon_10 PF10058.9 ELR11148.1 - 1.1 9.0 4.2 2.3 8.0 1.6 2.5 2 0 0 2 2 2 0 Predicted integral membrane zinc-ribbon metal-binding protein PH PF00169.29 ELR11149.1 - 5.2e-18 65.5 2.0 1.1e-09 38.7 0.1 2.7 2 1 0 2 2 2 2 PH domain FHA PF00498.26 ELR11149.1 - 1.8e-13 50.6 1.8 3.1e-13 49.9 1.8 1.4 1 0 0 1 1 1 1 FHA domain Yop-YscD_cpl PF16697.5 ELR11149.1 - 9.9e-13 48.2 0.1 2e-12 47.2 0.1 1.5 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain PH_11 PF15413.6 ELR11149.1 - 3.7e-06 27.3 5.3 0.0084 16.5 0.5 3.4 2 2 0 2 2 2 2 Pleckstrin homology domain PH_3 PF14593.6 ELR11149.1 - 0.00043 20.3 0.5 0.029 14.4 0.1 2.8 3 0 0 3 3 3 1 PH domain CBM_48 PF02922.18 ELR11149.1 - 0.049 14.0 0.3 0.49 10.8 0.1 2.6 1 1 1 2 2 2 0 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) PH_13 PF16652.5 ELR11149.1 - 0.094 12.5 0.4 1.1 9.1 0.0 2.3 2 0 0 2 2 2 0 Pleckstrin homology domain S1FA PF04689.13 ELR11149.1 - 0.57 10.4 3.4 0.46 10.7 0.8 2.1 2 0 0 2 2 2 0 DNA binding protein S1FA Arf PF00025.21 ELR11150.1 - 4.5e-67 224.9 0.0 4.9e-67 224.8 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 ELR11150.1 - 5.1e-14 52.5 0.0 7.1e-14 52.1 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase G-alpha PF00503.20 ELR11150.1 - 2.4e-13 50.0 0.5 1.6e-09 37.4 0.0 2.2 1 1 1 2 2 2 2 G-protein alpha subunit SRPRB PF09439.10 ELR11150.1 - 3.6e-13 49.3 0.0 4.3e-13 49.1 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Ras PF00071.22 ELR11150.1 - 4e-13 49.3 0.0 4.5e-13 49.1 0.0 1.1 1 0 0 1 1 1 1 Ras family Gtr1_RagA PF04670.12 ELR11150.1 - 8.4e-10 38.4 0.0 1e-09 38.1 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 ELR11150.1 - 4.3e-07 30.0 0.0 6.7e-07 29.4 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase cobW PF02492.19 ELR11150.1 - 0.0011 18.6 0.8 0.86 9.2 0.3 2.1 2 0 0 2 2 2 2 CobW/HypB/UreG, nucleotide-binding domain AAA_22 PF13401.6 ELR11150.1 - 0.0083 16.4 0.9 0.1 12.8 0.9 2.1 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.6 ELR11150.1 - 0.0085 16.6 0.1 0.013 16.0 0.1 1.5 1 1 0 1 1 1 1 AAA domain NACHT PF05729.12 ELR11150.1 - 0.0091 15.9 0.7 2 8.3 0.2 2.1 2 0 0 2 2 2 1 NACHT domain AAA_33 PF13671.6 ELR11150.1 - 0.011 15.9 0.3 0.031 14.4 0.3 1.9 1 1 0 1 1 1 0 AAA domain SRP54 PF00448.22 ELR11150.1 - 0.015 14.9 0.7 0.024 14.3 0.2 1.5 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain AAA_24 PF13479.6 ELR11150.1 - 0.017 14.9 0.2 0.024 14.4 0.2 1.3 1 1 0 1 1 1 0 AAA domain GTP_EFTU PF00009.27 ELR11150.1 - 0.021 14.4 0.1 0.14 11.7 0.0 1.9 1 1 1 2 2 2 0 Elongation factor Tu GTP binding domain ABC_tran PF00005.27 ELR11150.1 - 0.028 14.9 0.2 0.061 13.8 0.2 1.8 1 1 0 1 1 1 0 ABC transporter AAA_25 PF13481.6 ELR11150.1 - 0.047 13.3 0.7 0.086 12.4 0.7 1.5 1 1 0 1 1 1 0 AAA domain TsaE PF02367.17 ELR11150.1 - 0.085 12.9 0.1 0.13 12.2 0.0 1.4 1 1 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE MeaB PF03308.16 ELR11150.1 - 0.088 11.8 0.4 3.6 6.5 0.1 2.5 1 1 1 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB MobB PF03205.14 ELR11150.1 - 0.094 12.6 0.0 0.13 12.2 0.0 1.3 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B RsgA_GTPase PF03193.16 ELR11150.1 - 0.11 12.4 0.1 2 8.3 0.1 2.1 2 0 0 2 2 2 0 RsgA GTPase PduV-EutP PF10662.9 ELR11150.1 - 0.12 12.1 0.1 0.33 10.7 0.0 1.7 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation 6PF2K PF01591.18 ELR11150.1 - 0.15 11.3 0.0 0.23 10.7 0.0 1.2 1 0 0 1 1 1 0 6-phosphofructo-2-kinase AAA_16 PF13191.6 ELR11150.1 - 0.89 9.9 5.5 2.1 8.7 0.1 2.1 1 1 0 2 2 2 0 AAA ATPase domain Peptidase_S8 PF00082.22 ELR11151.1 - 1.8e-24 86.5 8.9 1.2e-22 80.6 2.9 2.2 1 1 1 2 2 2 2 Subtilase family P_proprotein PF01483.20 ELR11151.1 - 8.2e-16 57.8 0.8 1.5e-15 56.9 0.1 1.8 2 0 0 2 2 2 1 Proprotein convertase P-domain S8_pro-domain PF16470.5 ELR11151.1 - 3.4e-11 43.7 0.2 6.4e-11 42.9 0.2 1.5 1 0 0 1 1 1 1 Peptidase S8 pro-domain Phospholip_B PF04916.13 ELR11152.1 - 3.2e-160 534.2 6.8 2.9e-159 531.1 6.8 1.9 1 1 0 1 1 1 1 Phospholipase B WGG PF10273.9 ELR11153.1 - 0.00013 22.5 0.5 0.00025 21.6 0.5 1.5 1 0 0 1 1 1 1 Pre-rRNA-processing protein TSR2 RRP7 PF12923.7 ELR11153.1 - 0.16 12.1 0.2 0.16 12.1 0.2 2.4 2 1 0 2 2 2 0 Ribosomal RNA-processing protein 7 (RRP7) C-terminal domain DUF2788 PF10981.8 ELR11154.1 - 0.029 14.4 1.3 0.038 14.0 1.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2788) Phospholip_B PF04916.13 ELR11155.1 - 1.5e-29 103.0 0.0 1.5e-29 103.0 0.0 1.0 1 0 0 1 1 1 1 Phospholipase B HtrL_YibB PF09612.10 ELR11156.1 - 8.7e-05 22.2 0.0 0.00028 20.5 0.0 1.7 1 1 0 1 1 1 1 Bacterial protein of unknown function (HtrL_YibB) Methyltransf_11 PF08241.12 ELR11157.1 - 0.00051 20.6 0.0 0.00074 20.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ELR11157.1 - 0.0017 19.0 0.0 0.0025 18.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Actin PF00022.19 ELR11158.1 - 7.4e-105 350.9 0.1 5.3e-92 308.5 0.0 2.8 1 1 1 2 2 2 2 Actin Ank_2 PF12796.7 ELR11159.1 - 9.5e-11 42.1 0.0 1.4e-07 32.0 0.0 3.4 3 0 0 3 3 3 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 ELR11159.1 - 1.2e-10 40.7 1.5 0.00043 20.5 0.0 5.9 7 0 0 7 7 7 2 Ankyrin repeat Ank_5 PF13857.6 ELR11159.1 - 1.3e-08 34.9 0.1 6.4e-06 26.4 0.0 4.0 4 0 0 4 4 4 1 Ankyrin repeats (many copies) F-box-like PF12937.7 ELR11159.1 - 2.9e-08 33.5 0.3 8.8e-08 31.9 0.3 1.9 1 0 0 1 1 1 1 F-box-like Ank PF00023.30 ELR11159.1 - 4.4e-07 30.1 0.0 0.06 13.8 0.0 5.0 6 0 0 6 6 6 2 Ankyrin repeat Ank_4 PF13637.6 ELR11159.1 - 2.4e-06 28.0 0.1 0.061 13.9 0.0 4.1 4 0 0 4 4 4 2 Ankyrin repeats (many copies) F-box PF00646.33 ELR11159.1 - 0.00019 21.2 0.1 0.00041 20.1 0.1 1.6 1 0 0 1 1 1 1 F-box domain zf-HIT PF04438.16 ELR11160.1 - 1.4e-09 37.6 11.8 2.1e-09 37.1 11.8 1.3 1 0 0 1 1 1 1 HIT zinc finger SHQ1 PF04925.15 ELR11160.1 - 9.1e-05 22.1 0.0 0.00043 19.9 0.0 2.0 1 1 1 2 2 2 1 SHQ1 protein DUF5347 PF17282.2 ELR11160.1 - 0.045 14.0 3.7 0.043 14.1 1.7 1.9 2 0 0 2 2 2 0 Family of unknown function (DUF5347) Myc_N PF01056.18 ELR11160.1 - 0.59 10.0 15.2 0.95 9.3 1.0 3.2 3 0 0 3 3 3 0 Myc amino-terminal region zf-3CxxC_2 PF17180.4 ELR11160.1 - 0.9 10.3 6.2 3.4 8.5 6.2 2.1 1 1 0 1 1 1 0 Zinc-binding domain Proteasome PF00227.26 ELR11161.1 - 4.2e-57 192.7 0.0 6.8e-57 192.0 0.0 1.3 2 0 0 2 2 2 1 Proteasome subunit Proteasome_A_N PF10584.9 ELR11161.1 - 1e-10 41.1 0.8 2.4e-10 39.9 0.0 2.0 2 0 0 2 2 2 1 Proteasome subunit A N-terminal signature EIF_2_alpha PF07541.12 ELR11162.1 - 1.8e-20 73.2 0.1 4e-20 72.0 0.0 1.6 1 1 1 2 2 2 1 Eukaryotic translation initiation factor 2 alpha subunit Phage_Gp19 PF09355.10 ELR11162.1 - 0.069 13.6 0.0 0.11 13.0 0.0 1.3 1 0 0 1 1 1 0 Phage protein Gp19/Gp15/Gp42 Chromo PF00385.24 ELR11163.1 - 2e-09 37.2 0.4 4.3e-09 36.2 0.4 1.6 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain VirC1 PF07015.11 ELR11163.1 - 0.2 10.9 0.1 0.28 10.4 0.1 1.2 1 0 0 1 1 1 0 VirC1 protein Pkinase_Tyr PF07714.17 ELR11165.1 - 1.5e-126 421.0 0.0 2e-64 217.4 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 ELR11165.1 - 1.6e-108 362.1 0.0 2.8e-54 184.3 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain PBP_like_2 PF12849.7 ELR11165.1 - 1.6e-27 96.9 13.8 1.9e-13 50.8 1.0 2.3 2 0 0 2 2 2 2 PBP superfamily domain Guanylate_cyc PF00211.20 ELR11165.1 - 1.8e-14 53.8 0.0 3.4e-14 52.9 0.0 1.3 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain APH PF01636.23 ELR11165.1 - 4.5e-08 33.3 0.2 0.00018 21.5 0.0 3.7 2 1 1 3 3 3 2 Phosphotransferase enzyme family Haspin_kinase PF12330.8 ELR11165.1 - 0.00023 20.2 0.1 0.031 13.2 0.0 2.6 2 1 0 2 2 2 1 Haspin like kinase domain Kinase-like PF14531.6 ELR11165.1 - 0.00023 20.6 0.0 0.79 9.0 0.0 2.4 2 0 0 2 2 2 2 Kinase-like ABC1 PF03109.16 ELR11165.1 - 0.00045 20.4 0.0 0.015 15.5 0.0 2.8 3 0 0 3 3 3 1 ABC1 family EGF_2 PF07974.13 ELR11165.1 - 0.0037 17.6 12.3 0.007 16.7 12.3 1.5 1 0 0 1 1 1 1 EGF-like domain RIO1 PF01163.22 ELR11165.1 - 0.0054 16.4 1.6 0.38 10.3 0.7 3.0 2 1 0 2 2 2 1 RIO1 family FTA2 PF13095.6 ELR11165.1 - 0.043 13.4 0.1 0.51 9.9 0.0 2.6 2 1 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 PIP49_N PF14875.6 ELR11165.1 - 0.15 11.9 0.0 3.4 7.5 0.0 2.3 2 0 0 2 2 2 0 N-term cysteine-rich ER, FAM69 Dus PF01207.17 ELR11166.1 - 1.4e-64 218.1 0.0 1.8e-64 217.8 0.0 1.1 1 0 0 1 1 1 1 Dihydrouridine synthase (Dus) His_biosynth PF00977.21 ELR11166.1 - 7e-06 25.7 0.0 1.9e-05 24.3 0.0 1.6 2 0 0 2 2 2 1 Histidine biosynthesis protein ThiG PF05690.14 ELR11166.1 - 0.0008 18.8 0.0 0.0012 18.2 0.0 1.2 1 0 0 1 1 1 1 Thiazole biosynthesis protein ThiG TMP-TENI PF02581.17 ELR11166.1 - 0.0025 17.2 0.0 0.0051 16.2 0.0 1.5 1 0 0 1 1 1 1 Thiamine monophosphate synthase NMO PF03060.15 ELR11166.1 - 0.024 14.1 0.0 0.036 13.5 0.0 1.2 1 0 0 1 1 1 0 Nitronate monooxygenase G3P_antiterm PF04309.12 ELR11166.1 - 0.034 13.6 0.0 0.051 13.0 0.0 1.3 1 0 0 1 1 1 0 Glycerol-3-phosphate responsive antiterminator Cofilin_ADF PF00241.20 ELR11168.1 - 1.6e-14 53.7 0.0 1.4e-11 44.3 0.0 2.3 2 0 0 2 2 2 2 Cofilin/tropomyosin-type actin-binding protein F-box-like PF12937.7 ELR11168.1 - 4.2e-07 29.8 0.2 9.8e-07 28.6 0.2 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ELR11168.1 - 0.0023 17.8 0.0 0.0044 16.8 0.0 1.5 1 0 0 1 1 1 1 F-box domain Ank_2 PF12796.7 ELR11169.1 - 4.7e-75 248.2 18.3 2e-19 69.9 0.1 6.7 1 1 6 7 7 7 7 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ELR11169.1 - 9.8e-62 204.6 1.8 6.2e-09 36.2 0.0 10.5 5 4 6 11 11 11 10 Ankyrin repeats (many copies) Ank_3 PF13606.6 ELR11169.1 - 4.1e-56 180.4 9.8 2.5e-05 24.3 0.0 13.5 14 0 0 14 14 14 10 Ankyrin repeat Ank PF00023.30 ELR11169.1 - 3.4e-54 179.0 16.1 2.5e-06 27.6 0.1 12.9 14 0 0 14 14 14 11 Ankyrin repeat Ank_5 PF13857.6 ELR11169.1 - 1.4e-43 146.4 10.6 2.8e-08 33.9 0.1 10.3 2 2 9 11 11 11 10 Ankyrin repeats (many copies) GATase_7 PF13537.6 ELR11169.1 - 0.0079 16.1 0.0 5.2 7.0 0.0 4.0 3 2 2 5 5 5 1 Glutamine amidotransferase domain Aa_trans PF01490.18 ELR11170.1 - 8.2e-52 176.3 19.2 5.5e-31 107.7 1.4 2.5 2 1 1 3 3 3 2 Transmembrane amino acid transporter protein PetG PF02529.15 ELR11170.1 - 1.1 9.1 4.6 0.47 10.3 1.5 2.0 2 0 0 2 2 2 0 Cytochrome B6-F complex subunit 5 SH3_9 PF14604.6 ELR11171.1 - 1.6e-09 37.5 0.0 3.5e-09 36.4 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 ELR11171.1 - 2.7e-09 36.6 0.0 6.5e-09 35.3 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 ELR11171.1 - 1e-08 34.7 0.0 2.2e-08 33.6 0.0 1.6 1 0 0 1 1 1 1 SH3 domain EF-hand_6 PF13405.6 ELR11172.1 - 1.4e-10 40.2 0.7 3.3e-05 23.5 0.1 3.7 3 1 0 3 3 3 2 EF-hand domain EF-hand_7 PF13499.6 ELR11172.1 - 1.9e-10 41.0 1.1 0.00038 20.9 0.1 2.9 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 ELR11172.1 - 5.6e-10 38.1 0.9 1.7e-05 24.0 0.0 3.5 5 0 0 5 5 5 2 EF hand EF-hand_5 PF13202.6 ELR11172.1 - 2.8e-06 26.5 0.7 1.6e-05 24.2 0.1 2.4 3 0 0 3 3 3 1 EF hand EF-hand_8 PF13833.6 ELR11172.1 - 2.3e-05 24.2 1.0 0.017 15.0 0.0 3.2 3 1 0 3 3 3 2 EF-hand domain pair EF-hand_9 PF14658.6 ELR11172.1 - 7.1e-05 23.1 0.2 0.47 10.8 0.0 2.9 3 0 0 3 3 3 2 EF-hand domain EF-hand_4 PF12763.7 ELR11172.1 - 0.00016 21.6 0.5 0.0012 18.8 0.2 2.1 2 0 0 2 2 2 1 Cytoskeletal-regulatory complex EF hand Peptidase_S76 PF13611.6 ELR11172.1 - 0.0028 18.0 1.1 0.0055 17.0 1.1 1.6 1 1 0 1 1 1 1 Serine peptidase of plant viral polyprotein, P1 AbiEi_1 PF09407.10 ELR11172.1 - 0.027 14.8 0.2 1 9.6 0.0 2.1 2 0 0 2 2 2 0 AbiEi antitoxin C-terminal domain EF-hand_14 PF17959.1 ELR11172.1 - 0.056 13.8 1.2 0.35 11.2 0.4 2.3 2 2 0 2 2 2 0 EF-hand domain Protocadherin PF08374.11 ELR11172.1 - 0.12 12.4 1.9 0.16 11.9 1.9 1.3 1 0 0 1 1 1 0 Protocadherin Dot_icm_IcmQ PF09475.10 ELR11172.1 - 0.16 11.5 2.4 0.78 9.2 0.1 2.2 2 1 0 2 2 2 0 Dot/Icm secretion system protein (dot_icm_IcmQ) Fes1 PF08609.10 ELR11172.1 - 0.28 12.1 4.7 0.63 11.0 4.4 2.1 1 1 0 1 1 1 0 Nucleotide exchange factor Fes1 SPARC_Ca_bdg PF10591.9 ELR11172.1 - 0.3 11.4 3.0 7.9 6.8 0.0 2.7 1 1 1 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region PLAC8 PF04749.17 ELR11173.1 - 0.00014 22.8 29.6 0.00014 22.8 29.6 1.8 1 1 1 2 2 2 1 PLAC8 family RCC1 PF00415.18 ELR11174.1 - 2.8e-31 107.9 2.5 2.4e-14 53.7 0.1 5.6 6 0 0 6 6 6 4 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 ELR11174.1 - 1.2e-21 75.9 10.4 5.3e-08 32.5 0.4 5.6 5 0 0 5 5 5 4 Regulator of chromosome condensation (RCC1) repeat F-box-like PF12937.7 ELR11174.1 - 0.06 13.2 0.0 0.12 12.3 0.0 1.4 1 0 0 1 1 1 0 F-box-like HEAT PF02985.22 ELR11176.1 - 0.18 12.2 0.9 47 4.6 0.1 4.5 4 0 0 4 4 4 0 HEAT repeat Frizzled PF01534.17 ELR11178.1 - 3.9e-23 82.0 17.6 5.3e-23 81.6 17.6 1.1 1 0 0 1 1 1 1 Frizzled/Smoothened family membrane region Dicty_CAR PF05462.11 ELR11178.1 - 7.7e-07 28.5 4.1 1.4e-06 27.7 4.1 1.3 1 0 0 1 1 1 1 Slime mold cyclic AMP receptor Fz PF01392.22 ELR11178.1 - 2.4e-06 28.1 0.5 5.3e-06 27.0 0.5 1.5 1 0 0 1 1 1 1 Fz domain DUF3421 PF11901.8 ELR11179.1 - 1.4e-33 115.3 9.4 6e-17 61.7 1.9 2.9 1 1 2 3 3 3 3 Protein of unknown function (DUF3421) G-alpha PF00503.20 ELR11181.1 - 4.9e-55 187.1 7.3 5.6e-55 186.9 7.3 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 ELR11181.1 - 5.4e-10 39.0 1.9 9.7e-10 38.2 1.9 1.6 1 1 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 ELR11181.1 - 0.0034 17.0 1.2 0.005 16.4 1.2 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain G-alpha PF00503.20 ELR11182.1 - 1e-29 103.8 0.3 1.3e-29 103.4 0.3 1.1 1 0 0 1 1 1 1 G-protein alpha subunit Sigma54_activat PF00158.26 ELR11182.1 - 0.014 15.1 0.1 0.021 14.6 0.1 1.2 1 0 0 1 1 1 0 Sigma-54 interaction domain Arf PF00025.21 ELR11182.1 - 0.062 12.7 0.1 0.09 12.2 0.1 1.4 1 0 0 1 1 1 0 ADP-ribosylation factor family AAA_29 PF13555.6 ELR11182.1 - 0.065 13.0 0.0 0.12 12.2 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_24 PF13479.6 ELR11182.1 - 0.1 12.3 0.0 0.13 11.9 0.0 1.3 1 0 0 1 1 1 0 AAA domain adh_short PF00106.25 ELR11184.1 - 8e-43 146.2 0.0 1.2e-42 145.6 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ELR11184.1 - 4.9e-34 117.9 0.0 6.7e-34 117.5 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ELR11184.1 - 1.2e-10 41.6 0.1 1.7e-10 41.1 0.1 1.3 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 ELR11184.1 - 0.00088 18.8 0.0 0.0022 17.5 0.0 1.6 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 ELR11184.1 - 0.006 16.5 0.6 0.013 15.4 0.6 1.6 1 1 0 1 1 1 1 NAD(P)H-binding RmlD_sub_bind PF04321.17 ELR11184.1 - 0.057 12.5 0.2 0.1 11.7 0.2 1.3 1 0 0 1 1 1 0 RmlD substrate binding domain DUF3287 PF11690.8 ELR11184.1 - 0.17 11.6 0.0 0.33 10.7 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3287) DUF599 PF04654.12 ELR11185.1 - 1.6e-36 125.7 0.0 3.9e-36 124.4 0.0 1.5 1 1 0 1 1 1 1 Protein of unknown function, DUF599 PBP1_TM PF14812.6 ELR11185.1 - 0.11 12.9 0.7 0.17 12.3 0.7 1.2 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal MAP2_projctn PF08377.10 ELR11185.1 - 0.62 8.0 3.8 0.81 7.6 3.8 1.0 1 0 0 1 1 1 0 MAP2/Tau projection domain DUF2628 PF10947.8 ELR11185.1 - 1.3 9.4 6.3 0.89 10.0 1.9 2.8 2 1 0 2 2 2 0 Protein of unknown function (DUF2628) PAP_central PF04928.17 ELR11186.1 - 2.2e-45 154.6 0.0 4.1e-45 153.7 0.0 1.4 1 0 0 1 1 1 1 Poly(A) polymerase central domain 2_5_RNA_ligase2 PF13563.6 ELR11186.1 - 2.7e-35 121.5 0.5 6.8e-35 120.2 0.1 2.0 2 0 0 2 2 2 1 2'-5' RNA ligase superfamily MJ1316 PF04457.12 ELR11186.1 - 5.7e-16 59.0 0.4 1.4e-15 57.8 0.4 1.7 1 0 0 1 1 1 1 MJ1316 RNA cyclic group end recognition domain PAP_RNA-bind PF04926.15 ELR11186.1 - 6.3e-12 45.5 0.7 2.1e-11 43.8 0.0 2.3 3 0 0 3 3 3 1 Poly(A) polymerase predicted RNA binding domain Exo_endo_phos PF03372.23 ELR11186.1 - 6.1e-08 32.5 0.6 1.7e-07 31.0 0.2 2.0 2 0 0 2 2 2 1 Endonuclease/Exonuclease/phosphatase family NTP_transf_2 PF01909.23 ELR11186.1 - 0.0096 16.2 0.0 0.024 14.9 0.0 1.6 1 0 0 1 1 1 1 Nucleotidyltransferase domain LigT_PEase PF02834.16 ELR11186.1 - 0.012 15.7 0.1 3.9 7.7 0.1 2.7 2 0 0 2 2 2 0 LigT like Phosphoesterase PAP_central PF04928.17 ELR11187.1 - 1e-20 73.8 0.1 2.4e-20 72.6 0.0 1.7 2 0 0 2 2 2 1 Poly(A) polymerase central domain EGF_2 PF07974.13 ELR11187.1 - 6.8e-12 45.5 63.1 3e-05 24.3 15.7 4.6 4 0 0 4 4 4 4 EGF-like domain PAP_RNA-bind PF04926.15 ELR11187.1 - 6.4e-10 38.9 0.1 2.5e-09 37.0 0.0 2.0 2 0 0 2 2 2 1 Poly(A) polymerase predicted RNA binding domain EGF_Tenascin PF18720.1 ELR11187.1 - 2.1e-06 27.6 12.8 2.1e-06 27.6 12.8 5.1 6 0 0 6 6 6 2 Tenascin EGF domain PPC PF04151.15 ELR11187.1 - 0.018 16.1 8.8 1.6 9.8 0.5 4.4 4 0 0 4 4 4 0 Bacterial pre-peptidase C-terminal domain VERL PF11386.8 ELR11187.1 - 0.041 14.0 0.1 0.15 12.3 0.0 1.9 2 0 0 2 2 2 0 Vitelline envelope receptor for lysin EB PF01683.18 ELR11187.1 - 0.6 10.4 40.7 0.11 12.8 7.7 4.4 4 0 0 4 4 4 0 EB module EGF PF00008.27 ELR11187.1 - 5.1 7.5 50.3 0.12 12.8 10.6 4.3 4 0 0 4 4 4 0 EGF-like domain VERL PF11386.8 ELR11188.1 - 0.035 14.3 0.0 0.076 13.2 0.0 1.5 1 0 0 1 1 1 0 Vitelline envelope receptor for lysin VanY PF02557.17 ELR11188.1 - 0.14 12.0 0.4 0.23 11.3 0.4 1.5 1 0 0 1 1 1 0 D-alanyl-D-alanine carboxypeptidase GREB1 PF15782.5 ELR11188.1 - 0.15 9.2 0.3 0.16 9.1 0.3 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Nop14 PF04147.12 ELR11188.1 - 1.6 6.9 7.4 1.7 6.8 7.4 1.0 1 0 0 1 1 1 0 Nop14-like family Dicty_REP PF05086.12 ELR11188.1 - 3.3 5.6 6.2 4.2 5.2 6.2 1.0 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein RsgA_GTPase PF03193.16 ELR11189.1 - 0.045 13.7 0.1 0.086 12.7 0.1 1.4 1 0 0 1 1 1 0 RsgA GTPase Septin PF00735.18 ELR11189.1 - 0.19 11.0 0.0 0.21 10.8 0.0 1.1 1 0 0 1 1 1 0 Septin Pkinase_Tyr PF07714.17 ELR11190.1 - 1.2e-54 185.3 0.0 1.9e-54 184.7 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ELR11190.1 - 8.4e-44 149.9 0.0 1.3e-43 149.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain COR PF16095.5 ELR11190.1 - 6.2e-06 26.2 0.0 0.0051 16.6 0.0 2.4 2 0 0 2 2 2 2 C-terminal of Roc, COR, domain YccF PF03733.13 ELR11191.1 - 1.6e-23 83.1 32.1 1.9e-14 54.1 11.8 2.2 2 0 0 2 2 2 2 Inner membrane component domain DUF2207 PF09972.9 ELR11191.1 - 0.074 11.8 3.7 0.093 11.5 3.7 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF1639 PF07797.14 ELR11191.1 - 0.13 12.3 0.0 0.24 11.4 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1639) Neuropeptide_S PF14993.6 ELR11191.1 - 0.14 12.0 0.0 0.28 11.0 0.0 1.4 1 0 0 1 1 1 0 Neuropeptide S precursor protein Wzy_C_2 PF11846.8 ELR11191.1 - 0.7 9.8 4.8 0.18 11.7 0.9 1.8 1 1 1 2 2 2 0 Virulence factor membrane-bound polymerase, C-terminal PrgI PF12666.7 ELR11191.1 - 5.1 7.9 13.4 0.61 10.8 3.2 2.3 2 0 0 2 2 2 0 PrgI family protein Pkinase PF00069.25 ELR11195.1 - 2.4e-21 76.3 0.0 7.3e-21 74.7 0.0 1.7 1 1 1 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR11195.1 - 2.9e-10 39.9 0.0 4.1e-10 39.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 ELR11195.1 - 4.2e-06 26.9 0.0 7.2e-06 26.1 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Seadorna_VP7 PF07387.11 ELR11195.1 - 0.00015 21.0 0.1 0.00036 19.7 0.0 1.6 2 0 0 2 2 2 1 Seadornavirus VP7 Pkinase_fungal PF17667.1 ELR11195.1 - 0.0076 15.1 0.0 0.011 14.6 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Choline_kinase PF01633.20 ELR11195.1 - 0.03 13.9 0.0 0.061 12.9 0.0 1.4 1 0 0 1 1 1 0 Choline/ethanolamine kinase RIO1 PF01163.22 ELR11195.1 - 0.14 11.7 0.0 0.27 10.8 0.0 1.4 1 0 0 1 1 1 0 RIO1 family Antibiotic_NAT PF02522.14 ELR11196.1 - 8.3e-57 192.5 0.0 1.3e-56 191.9 0.0 1.3 1 1 0 1 1 1 1 Aminoglycoside 3-N-acetyltransferase WD40 PF00400.32 ELR11197.1 - 5.8e-13 49.1 27.4 0.0001 23.0 1.5 6.3 6 0 0 6 6 6 3 WD domain, G-beta repeat F-box-like PF12937.7 ELR11197.1 - 5.1e-09 35.9 0.6 1.1e-08 34.8 0.6 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ELR11197.1 - 0.00042 20.1 1.0 0.0009 19.1 1.0 1.6 1 0 0 1 1 1 1 F-box domain F-box_5 PF18511.1 ELR11197.1 - 0.076 12.6 0.0 0.24 11.0 0.0 1.9 1 0 0 1 1 1 0 F-box Prot_ATP_ID_OB PF16450.5 ELR11197.1 - 0.16 11.9 0.0 0.38 10.8 0.0 1.7 1 0 0 1 1 1 0 Proteasomal ATPase OB C-terminal domain TFIID-31kDa PF02291.15 ELR11198.1 - 4.1e-36 123.7 0.0 6.4e-36 123.1 0.0 1.3 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit Bromo_TP PF07524.13 ELR11198.1 - 6.6e-07 29.3 0.0 2.1e-06 27.7 0.0 1.8 2 0 0 2 2 2 1 Bromodomain associated CENP-S PF15630.6 ELR11198.1 - 5.9e-05 23.4 0.1 0.0001 22.6 0.1 1.3 1 0 0 1 1 1 1 CENP-S protein Histone PF00125.24 ELR11198.1 - 0.019 15.3 0.7 0.064 13.6 0.0 2.1 2 0 0 2 2 2 0 Core histone H2A/H2B/H3/H4 CENP-T_C PF15511.6 ELR11198.1 - 0.034 14.3 0.0 0.062 13.4 0.0 1.5 1 0 0 1 1 1 0 Centromere kinetochore component CENP-T histone fold DUF515 PF04415.12 ELR11198.1 - 2 6.7 8.3 74 1.5 10.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF515) DUF4679 PF15728.5 ELR11198.1 - 7.6 5.4 15.5 11 4.9 15.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4679) DUF3419 PF11899.8 ELR11199.1 - 1.2e-112 377.0 0.1 1.4e-112 376.7 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3419) DENN PF02141.21 ELR11201.1 - 4.7e-23 82.1 1.2 6.9e-20 71.8 0.5 2.6 2 0 0 2 2 2 2 DENN (AEX-3) domain uDENN PF03456.18 ELR11201.1 - 1.2e-09 38.8 0.0 4.5e-09 36.9 0.0 2.1 1 0 0 1 1 1 1 uDENN domain BTB PF00651.31 ELR11202.1 - 4.6e-22 78.3 0.2 2.8e-20 72.6 0.0 2.9 3 1 1 4 4 4 1 BTB/POZ domain BACK PF07707.15 ELR11202.1 - 7.1e-16 58.2 0.1 4.5e-15 55.6 0.0 2.1 2 0 0 2 2 2 1 BTB And C-terminal Kelch SPRY PF00622.28 ELR11202.1 - 7.8e-13 48.6 2.2 7.8e-13 48.6 2.2 1.6 2 0 0 2 2 2 1 SPRY domain Neuralized PF07177.12 ELR11202.1 - 0.0052 16.8 0.1 0.009 16.0 0.1 1.4 1 0 0 1 1 1 1 Neuralized zf-RING_2 PF13639.6 ELR11203.1 - 2.9e-08 33.9 17.2 4.9e-08 33.2 17.2 1.4 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_3 PF13920.6 ELR11203.1 - 7.7e-07 28.9 12.3 1.3e-06 28.2 12.3 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ELR11203.1 - 1.3e-05 25.0 12.9 2.6e-05 24.1 12.9 1.5 1 0 0 1 1 1 1 zinc-RING finger domain Prok-RING_4 PF14447.6 ELR11203.1 - 2.7e-05 23.9 11.4 5.6e-05 22.9 11.4 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_2 PF13923.6 ELR11203.1 - 3.4e-05 23.6 16.0 6.3e-05 22.7 16.0 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 ELR11203.1 - 0.00048 20.4 13.2 0.0014 18.9 13.2 1.8 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 ELR11203.1 - 0.00058 19.7 17.4 0.001 18.9 17.4 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 ELR11203.1 - 0.00069 19.6 4.8 0.0013 18.7 4.8 1.4 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger P_C PF06640.11 ELR11203.1 - 0.023 14.8 2.0 0.051 13.7 2.0 1.5 1 0 0 1 1 1 0 P protein C-terminus zf-RING_UBOX PF13445.6 ELR11203.1 - 0.044 13.8 15.6 0.6 10.2 11.1 2.4 2 0 0 2 2 2 0 RING-type zinc-finger zf-P11 PF03854.14 ELR11203.1 - 0.24 11.1 10.6 0.44 10.3 10.6 1.3 1 0 0 1 1 1 0 P-11 zinc finger Asparaginase_2 PF01112.18 ELR11204.1 - 7.8e-21 74.4 4.6 9.4e-19 67.6 4.6 3.0 1 1 0 1 1 1 1 Asparaginase CENP-B_dimeris PF09026.10 ELR11204.1 - 2.9 8.4 11.4 0.45 10.9 0.3 3.0 3 0 0 3 3 3 0 Centromere protein B dimerisation domain AC_N PF16214.5 ELR11204.1 - 9.8 5.2 7.7 1.1 8.3 3.3 1.5 2 0 0 2 2 2 0 Adenylyl cyclase N-terminal extracellular and transmembrane region DUF218 PF02698.17 ELR11205.1 - 1.1e-19 70.8 0.0 2.6e-19 69.5 0.0 1.6 1 1 0 1 1 1 1 DUF218 domain LppC PF04348.13 ELR11205.1 - 0.015 14.2 0.0 0.02 13.7 0.0 1.1 1 0 0 1 1 1 0 LppC putative lipoprotein CSTF_C PF14304.6 ELR11206.1 - 0.34 10.5 1.7 1.6 8.4 0.3 2.4 2 0 0 2 2 2 0 Transcription termination and cleavage factor C-terminal PAH PF02671.21 ELR11207.1 - 6.3e-31 106.3 1.7 5e-15 55.4 0.4 2.5 2 0 0 2 2 2 2 Paired amphipathic helix repeat Hydrolase PF00702.26 ELR11208.1 - 9.5e-20 71.8 0.9 1.9e-19 70.8 0.9 1.5 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.20 ELR11208.1 - 1.5e-13 50.7 7.2 4.2e-12 46.0 3.1 3.6 3 0 0 3 3 3 1 E1-E2 ATPase Hydrolase_3 PF08282.12 ELR11208.1 - 0.0021 17.8 1.2 0.0097 15.7 0.3 2.1 1 1 1 2 2 2 1 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 ELR11208.1 - 0.0037 17.3 0.0 0.0096 16.0 0.0 1.7 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Cation_ATPase_C PF00689.21 ELR11208.1 - 1.9 8.2 10.1 0.13 11.9 4.5 1.9 2 0 0 2 2 2 0 Cation transporting ATPase, C-terminus Complex1_LYR PF05347.15 ELR11209.1 - 3.4e-13 49.4 4.5 4.1e-13 49.2 4.5 1.1 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_2 PF13233.6 ELR11209.1 - 3.2e-05 24.6 3.4 3.8e-05 24.3 3.4 1.2 1 0 0 1 1 1 1 Complex1_LYR-like TPR_12 PF13424.6 ELR11209.1 - 0.0047 17.2 0.7 0.0079 16.5 0.7 1.4 1 0 0 1 1 1 1 Tetratricopeptide repeat HBM PF16591.5 ELR11209.1 - 0.013 14.9 0.6 0.05 13.0 0.1 1.8 1 1 1 2 2 2 0 Helical bimodular sensor domain Complex1_LYR_1 PF13232.6 ELR11209.1 - 0.061 13.9 3.0 0.13 12.8 3.0 1.6 1 1 0 1 1 1 0 Complex1_LYR-like BTB_2 PF02214.22 ELR11211.1 - 1.1e-21 76.9 0.0 2.1e-20 72.8 0.0 2.4 2 0 0 2 2 2 1 BTB/POZ domain BTB_3 PF16017.5 ELR11211.1 - 6.8e-07 29.4 0.0 1.4e-06 28.3 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain DUF3878 PF12994.7 ELR11211.1 - 0.21 11.0 0.0 0.35 10.3 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function, E. rectale Gene description (DUF3878) CCDC53 PF10152.9 ELR11211.1 - 2.4 8.5 6.1 1.5 9.3 2.8 2.1 2 0 0 2 2 2 0 Subunit CCDC53 of WASH complex AAA_18 PF13238.6 ELR11212.1 - 1.8e-07 31.8 0.0 3.2e-07 31.0 0.0 1.4 1 0 0 1 1 1 1 AAA domain PRK PF00485.18 ELR11212.1 - 3e-05 23.8 0.1 0.031 14.0 0.0 2.3 1 1 1 2 2 2 2 Phosphoribulokinase / Uridine kinase family AAA_28 PF13521.6 ELR11212.1 - 0.00036 20.8 0.0 0.00065 20.0 0.0 1.4 1 0 0 1 1 1 1 AAA domain dNK PF01712.19 ELR11212.1 - 0.0014 18.6 0.0 0.6 9.9 0.0 2.2 1 1 1 2 2 2 2 Deoxynucleoside kinase AAA_33 PF13671.6 ELR11212.1 - 0.006 16.7 0.0 0.019 15.2 0.0 1.9 1 1 0 1 1 1 1 AAA domain MMR_HSR1 PF01926.23 ELR11212.1 - 0.012 15.7 0.1 0.025 14.7 0.1 1.5 1 0 0 1 1 1 0 50S ribosome-binding GTPase GTP_EFTU PF00009.27 ELR11212.1 - 0.034 13.7 0.0 0.055 13.0 0.0 1.3 1 0 0 1 1 1 0 Elongation factor Tu GTP binding domain AAA_22 PF13401.6 ELR11212.1 - 0.065 13.5 0.0 0.14 12.4 0.0 1.6 1 0 0 1 1 1 0 AAA domain Dynamin_N PF00350.23 ELR11212.1 - 0.073 13.1 0.1 0.12 12.4 0.1 1.3 1 0 0 1 1 1 0 Dynamin family Ank_2 PF12796.7 ELR11212.1 - 0.081 13.5 0.0 0.52 10.9 0.0 2.2 2 0 0 2 2 2 0 Ankyrin repeats (3 copies) MeaB PF03308.16 ELR11212.1 - 0.18 10.7 0.1 0.3 10.0 0.1 1.2 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_17 PF13207.6 ELR11212.1 - 0.19 12.2 0.0 2.2 8.7 0.0 2.5 1 1 0 1 1 1 0 AAA domain ABC_tran PF00005.27 ELR11212.1 - 0.19 12.3 0.0 0.39 11.2 0.0 1.5 1 0 0 1 1 1 0 ABC transporter AAA_14 PF13173.6 ELR11212.1 - 0.2 11.7 0.0 0.4 10.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain Spore_IV_A PF09547.10 ELR11212.1 - 0.25 10.3 0.0 0.35 9.8 0.0 1.1 1 0 0 1 1 1 0 Stage IV sporulation protein A (spore_IV_A) D123 PF07065.14 ELR11213.1 - 2.4e-19 69.7 0.0 6.1e-18 65.0 0.0 2.3 2 1 1 3 3 3 1 D123 R2K_2 PF18299.1 ELR11213.1 - 0.018 14.9 0.0 0.034 14.0 0.0 1.5 1 0 0 1 1 1 0 ATP-grasp domain, R2K clade family 2 R2K_3 PF14243.6 ELR11213.1 - 0.033 14.2 0.0 0.084 12.9 0.0 1.8 2 1 0 2 2 2 0 ATP-grasp domain, R2K clade family 3 NUDIX PF00293.28 ELR11214.1 - 2.2e-06 27.8 0.3 4.1e-05 23.6 0.3 2.2 1 1 0 1 1 1 1 NUDIX domain D123 PF07065.14 ELR11215.1 - 2.2e-20 73.0 0.0 4.2e-17 62.3 0.0 2.1 2 0 0 2 2 2 2 D123 R2K_2 PF18299.1 ELR11215.1 - 0.00018 21.4 0.0 0.00037 20.4 0.0 1.5 1 0 0 1 1 1 1 ATP-grasp domain, R2K clade family 2 R2K_3 PF14243.6 ELR11215.1 - 0.0012 18.8 0.1 0.0056 16.7 0.1 2.1 1 1 1 2 2 2 1 ATP-grasp domain, R2K clade family 3 T4_Rnl2_C PF18043.1 ELR11217.1 - 4.2e-21 74.9 0.1 8.6e-21 73.9 0.1 1.5 1 0 0 1 1 1 1 T4 RNA ligase 2 C-terminal RNA_ligase PF09414.10 ELR11217.1 - 2.8e-18 66.8 0.0 4.7e-18 66.0 0.0 1.3 1 0 0 1 1 1 1 RNA ligase MFS_1 PF07690.16 ELR11219.1 - 2.5e-19 69.4 29.0 5.8e-11 41.9 10.9 2.5 1 1 1 2 2 2 2 Major Facilitator Superfamily UNC-93 PF05978.16 ELR11219.1 - 4.1e-12 46.1 12.0 1.1e-11 44.7 7.9 3.0 2 1 0 2 2 2 1 Ion channel regulatory protein UNC-93 PUCC PF03209.15 ELR11219.1 - 0.76 8.7 14.7 0.18 10.8 11.0 1.8 2 0 0 2 2 2 0 PUCC protein ubiquitin PF00240.23 ELR11220.1 - 1.5e-69 229.7 6.9 2.8e-34 116.7 0.8 2.1 2 0 0 2 2 2 2 Ubiquitin family Rad60-SLD PF11976.8 ELR11220.1 - 9e-34 115.1 7.4 2.2e-16 59.5 0.8 2.2 2 0 0 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 ELR11220.1 - 1e-12 48.3 2.1 7.6e-05 23.1 0.2 3.2 2 2 0 2 2 2 2 Ubiquitin-like domain zf-AN1 PF01428.16 ELR11220.1 - 5.1e-10 39.3 11.8 8.9e-10 38.6 11.8 1.4 1 0 0 1 1 1 1 AN1-like Zinc finger TBK1_ULD PF18396.1 ELR11220.1 - 6.5e-08 32.4 1.0 0.012 15.6 0.1 2.3 2 0 0 2 2 2 2 TANK binding kinase 1 ubiquitin-like domain Ubiquitin_5 PF18037.1 ELR11220.1 - 1.4e-07 31.8 1.4 0.017 15.5 0.1 2.2 1 1 0 2 2 2 2 Ubiquitin-like domain DUF2407 PF10302.9 ELR11220.1 - 1.5e-07 31.9 0.2 0.021 15.3 0.0 2.2 1 1 1 2 2 2 2 DUF2407 ubiquitin-like domain Rad60-SLD_2 PF13881.6 ELR11220.1 - 1.7e-07 31.3 0.5 0.028 14.5 0.1 2.9 2 2 0 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_4 PF18036.1 ELR11220.1 - 0.00018 21.5 8.8 4.8 7.3 0.2 4.3 4 0 0 4 4 4 2 Ubiquitin-like domain Sde2_N_Ubi PF13019.6 ELR11220.1 - 0.00023 21.0 0.1 0.59 9.9 0.0 2.3 1 1 1 2 2 2 2 Silencing defective 2 N-terminal ubiquitin domain DUF3861 PF12977.7 ELR11220.1 - 0.0021 18.2 0.3 3 8.1 0.0 2.3 2 0 0 2 2 2 2 Domain of Unknown Function with PDB structure (DUF3861) ACT_5 PF13710.6 ELR11220.1 - 0.072 12.9 0.9 12 5.8 0.1 2.4 2 0 0 2 2 2 0 ACT domain Plexin_cytopl PF08337.12 ELR11220.1 - 0.08 11.6 4.4 5.9 5.4 0.7 3.2 3 1 0 3 3 3 0 Plexin cytoplasmic RasGAP domain DUF2870 PF11069.8 ELR11220.1 - 0.085 13.2 0.0 24 5.4 0.0 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2870) Raf1_HTH PF18579.1 ELR11220.1 - 0.15 11.8 0.1 25 4.7 0.0 2.3 2 0 0 2 2 2 0 Rubisco accumulation factor 1 helix turn helix domain Big_3_3 PF13750.6 ELR11220.1 - 0.15 11.7 0.0 21 4.7 0.0 2.3 2 0 0 2 2 2 0 Bacterial Ig-like domain (group 3) PI3K_p85B PF02192.16 ELR11220.1 - 0.45 10.3 2.3 21 5.0 0.2 2.4 2 0 0 2 2 2 0 PI3-kinase family, p85-binding domain Tash_PEST PF07708.11 ELR11220.1 - 0.47 10.7 9.6 4.3 7.6 1.5 2.3 2 0 0 2 2 2 0 Tash protein PEST motif IBN_N PF03810.19 ELR11221.1 - 5.7e-17 61.4 1.8 1.6e-14 53.6 0.1 2.7 2 0 0 2 2 2 2 Importin-beta N-terminal domain CAS_CSE1 PF03378.15 ELR11221.1 - 1.5e-09 36.8 0.1 1.5e-09 36.8 0.1 3.5 4 1 0 4 4 4 1 CAS/CSE protein, C-terminus Cse1 PF08506.10 ELR11221.1 - 9e-05 21.5 0.0 0.00049 19.0 0.0 2.2 1 1 0 1 1 1 1 Cse1 HEAT_EZ PF13513.6 ELR11221.1 - 0.00064 20.2 2.8 2.5 8.7 0.0 4.5 3 0 0 3 3 3 2 HEAT-like repeat Tti2 PF10521.9 ELR11221.1 - 0.039 13.5 3.9 13 5.2 0.0 3.8 3 1 1 4 4 4 0 Tti2 family HEAT PF02985.22 ELR11221.1 - 0.094 13.0 5.0 21 5.7 0.1 5.6 5 0 0 5 5 5 0 HEAT repeat Xpo1 PF08389.12 ELR11221.1 - 0.14 12.2 0.2 6.4 6.8 0.0 3.5 4 0 0 4 4 4 0 Exportin 1-like protein BUD22 PF09073.10 ELR11221.1 - 0.19 11.0 4.9 0.31 10.3 4.9 1.2 1 0 0 1 1 1 0 BUD22 DNA_pol_phi PF04931.13 ELR11221.1 - 3.1 5.8 23.1 1.2 7.1 19.2 2.1 2 0 0 2 2 2 0 DNA polymerase phi Cnd2 PF05786.14 ELR11221.1 - 4 6.0 8.3 6.1 5.4 8.3 1.1 1 0 0 1 1 1 0 Condensin complex subunit 2 GCIP PF13324.6 ELR11221.1 - 9.9 5.7 11.2 23 4.5 7.8 2.8 3 0 0 3 3 3 0 Grap2 and cyclin-D-interacting Methyltransf_24 PF13578.6 ELR11222.1 - 1e-11 45.8 0.0 1.8e-11 45.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Proteasome PF00227.26 ELR11223.1 - 2.3e-58 196.8 0.1 2.8e-58 196.5 0.1 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 ELR11223.1 - 5.4e-14 51.5 0.0 1.3e-13 50.3 0.0 1.7 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature CENP-K PF11802.8 ELR11225.1 - 1.5e-13 50.9 0.2 7.9e-13 48.6 0.1 2.0 1 1 0 1 1 1 1 Centromere-associated protein K Med9 PF07544.13 ELR11225.1 - 0.69 10.0 7.4 2.2 8.4 0.1 3.7 4 0 0 4 4 4 0 RNA polymerase II transcription mediator complex subunit 9 RRP7 PF12923.7 ELR11225.1 - 1 9.5 0.0 1 9.5 0.0 3.0 3 1 0 3 3 3 0 Ribosomal RNA-processing protein 7 (RRP7) C-terminal domain 2OG-FeII_Oxy_2 PF13532.6 ELR11227.1 - 1.6e-26 93.7 0.0 2.6e-26 93.0 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily RRM_1 PF00076.22 ELR11228.1 - 1e-17 63.7 0.0 1.6e-17 63.1 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 ELR11228.1 - 0.0059 16.7 0.0 0.012 15.8 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif Peptidase_M76 PF09768.9 ELR11230.1 - 2.2e-10 40.6 7.5 0.00011 22.0 2.4 3.2 1 1 1 2 2 2 2 Peptidase M76 family Toxin_22 PF08092.11 ELR11230.1 - 0.18 11.8 2.0 0.26 11.4 0.2 2.1 2 0 0 2 2 2 0 Magi peptide toxin family MAPEG PF01124.18 ELR11231.1 - 1.5e-13 50.8 3.3 2.5e-13 50.1 3.3 1.4 1 1 0 1 1 1 1 MAPEG family IU_nuc_hydro PF01156.19 ELR11232.1 - 2.3e-26 93.1 2.4 1.8e-21 77.0 1.5 3.6 2 2 0 3 3 3 3 Inosine-uridine preferring nucleoside hydrolase DUF1593 PF07632.11 ELR11232.1 - 0.019 14.4 0.1 0.031 13.7 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1593) DUF1168 PF06658.12 ELR11232.1 - 0.54 10.1 6.2 0.44 10.3 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1168) SIR2 PF02146.17 ELR11233.1 - 1.2e-13 51.4 0.0 3.2e-12 46.7 0.0 2.2 1 1 0 1 1 1 1 Sir2 family ABC_membrane_2 PF06472.15 ELR11235.1 - 6.4e-89 297.9 3.8 8.4e-89 297.5 3.8 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region 2 ABC_tran PF00005.27 ELR11235.1 - 1e-18 68.2 0.0 2.4e-18 67.0 0.0 1.7 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 ELR11235.1 - 0.00028 20.8 0.2 0.00064 19.6 0.0 1.7 2 0 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 ELR11235.1 - 0.0047 16.4 0.0 0.35 10.3 0.0 2.3 2 0 0 2 2 2 1 RecF/RecN/SMC N terminal domain Rad17 PF03215.15 ELR11235.1 - 0.0069 16.3 0.0 0.014 15.3 0.0 1.4 1 0 0 1 1 1 1 Rad17 P-loop domain AAA_23 PF13476.6 ELR11235.1 - 0.011 16.3 0.1 0.011 16.3 0.1 2.1 3 0 0 3 3 3 0 AAA domain AAA_29 PF13555.6 ELR11235.1 - 0.016 14.9 0.0 0.039 13.7 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_16 PF13191.6 ELR11235.1 - 0.08 13.3 0.3 0.32 11.4 0.1 2.0 2 0 0 2 2 2 0 AAA ATPase domain Lar_restr_allev PF14354.6 ELR11237.1 - 0.063 13.7 5.6 0.22 11.9 0.1 2.4 2 1 0 2 2 2 0 Restriction alleviation protein Lar FKBP_N PF01346.18 ELR11238.1 - 7.9 7.5 8.4 0.62 11.1 0.3 2.7 1 1 0 2 2 2 0 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase Myotub-related PF06602.14 ELR11239.1 - 0.012 14.6 0.2 3.6 6.4 0.1 2.7 2 1 0 2 2 2 0 Myotubularin-like phosphatase domain Red1 PF07964.11 ELR11240.1 - 0.025 12.8 0.5 0.032 12.5 0.5 1.1 1 0 0 1 1 1 0 Rec10 / Red1 NST1 PF13945.6 ELR11240.1 - 0.085 13.0 0.8 0.13 12.3 0.8 1.2 1 0 0 1 1 1 0 Salt tolerance down-regulator SNF2_N PF00176.23 ELR11241.1 - 1.2e-51 175.5 5.0 1.1e-50 172.4 5.0 2.2 1 1 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 ELR11241.1 - 9.1e-11 42.1 0.0 9.7e-10 38.8 0.0 2.6 2 1 0 2 2 1 1 Helicase conserved C-terminal domain zf-C3HC4_2 PF13923.6 ELR11241.1 - 1.6e-09 37.4 7.0 3.3e-09 36.4 7.0 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 ELR11241.1 - 3e-08 33.8 6.8 5.7e-08 33.0 6.8 1.5 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_3 PF13920.6 ELR11241.1 - 7.7e-07 28.9 5.7 1.4e-06 28.1 5.7 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 ELR11241.1 - 9.6e-07 28.6 7.0 1.7e-06 27.8 7.0 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ELR11241.1 - 2.1e-06 27.5 5.8 3.9e-06 26.7 5.8 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-rbx1 PF12678.7 ELR11241.1 - 1.9e-05 24.9 3.5 4.4e-05 23.7 3.5 1.6 1 0 0 1 1 1 1 RING-H2 zinc finger domain ResIII PF04851.15 ELR11241.1 - 2e-05 24.6 0.0 6.5e-05 23.0 0.0 1.9 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit zf-RING_UBOX PF13445.6 ELR11241.1 - 5.1e-05 23.2 6.8 0.0001 22.2 6.8 1.5 1 0 0 1 1 1 1 RING-type zinc-finger DEAD PF00270.29 ELR11241.1 - 0.00013 21.8 0.0 0.00035 20.4 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase zf-ANAPC11 PF12861.7 ELR11241.1 - 0.00059 19.8 1.8 0.0012 18.9 1.8 1.4 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger Rad50_zn_hook PF04423.14 ELR11241.1 - 0.00069 19.4 0.7 2 8.3 0.2 3.0 2 0 0 2 2 2 2 Rad50 zinc hook motif zf-RING_4 PF14570.6 ELR11241.1 - 0.0017 18.1 6.7 0.0031 17.3 6.7 1.4 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain zf-C3HC4_4 PF15227.6 ELR11241.1 - 0.0072 16.5 7.6 0.014 15.5 7.6 1.5 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-C3HC4_5 PF17121.5 ELR11241.1 - 0.013 15.4 4.3 0.029 14.2 4.3 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 ELR11241.1 - 0.07 12.9 4.0 0.15 11.8 4.0 1.6 1 0 0 1 1 1 0 RING-like zinc finger Prok-RING_4 PF14447.6 ELR11241.1 - 0.076 12.9 9.0 0.56 10.1 9.4 2.1 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 DiS_P_DiS PF06750.13 ELR11241.1 - 0.11 12.7 0.2 0.25 11.5 0.2 1.6 1 0 0 1 1 1 0 Bacterial Peptidase A24 N-terminal domain zf-RING_6 PF14835.6 ELR11241.1 - 0.17 11.8 4.9 0.4 10.6 4.9 1.5 1 0 0 1 1 1 0 zf-RING of BARD1-type protein Zn_ribbon_17 PF17120.5 ELR11241.1 - 0.24 11.1 4.2 0.46 10.1 4.2 1.4 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type Zn_Tnp_IS91 PF14319.6 ELR11241.1 - 0.29 11.2 2.3 0.81 9.8 2.3 1.8 1 0 0 1 1 1 0 Transposase zinc-binding domain Siva PF05458.12 ELR11241.1 - 0.32 10.6 4.9 0.68 9.6 4.9 1.5 1 0 0 1 1 1 0 Cd27 binding protein (Siva) DZR PF12773.7 ELR11241.1 - 1.6 8.8 8.1 8 6.6 8.1 2.0 1 1 0 1 1 1 0 Double zinc ribbon zf-C3H2C3 PF17122.5 ELR11241.1 - 9.4 6.4 8.6 37 4.5 8.7 1.9 1 1 1 2 2 2 0 Zinc-finger F-box-like PF12937.7 ELR11242.1 - 3e-08 33.4 1.2 6.1e-08 32.4 1.2 1.6 1 0 0 1 1 1 1 F-box-like Arf PF00025.21 ELR11242.1 - 0.00018 21.0 0.0 0.72 9.3 0.1 2.8 2 1 0 2 2 2 2 ADP-ribosylation factor family AAA_33 PF13671.6 ELR11242.1 - 0.012 15.8 0.0 0.035 14.3 0.0 1.9 1 1 0 1 1 1 0 AAA domain F-box PF00646.33 ELR11242.1 - 0.023 14.6 0.1 0.05 13.5 0.1 1.5 1 0 0 1 1 1 0 F-box domain G-alpha PF00503.20 ELR11242.1 - 0.061 12.5 0.0 1.7 7.7 0.0 2.0 2 0 0 2 2 2 0 G-protein alpha subunit Dynamin_N PF00350.23 ELR11242.1 - 0.081 13.0 0.0 0.15 12.1 0.0 1.4 1 0 0 1 1 1 0 Dynamin family ATP_bind_1 PF03029.17 ELR11242.1 - 0.088 12.6 0.0 1.3 8.8 0.0 2.0 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein Gtr1_RagA PF04670.12 ELR11242.1 - 0.1 11.9 0.0 0.38 10.1 0.0 1.7 2 0 0 2 2 2 0 Gtr1/RagA G protein conserved region KTI12 PF08433.10 ELR11242.1 - 0.15 11.5 0.0 0.22 10.9 0.0 1.2 1 0 0 1 1 1 0 Chromatin associated protein KTI12 AAA_18 PF13238.6 ELR11242.1 - 0.16 12.6 0.0 0.3 11.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 ELR11242.1 - 0.16 11.9 0.0 9.4 6.1 0.0 2.2 2 0 0 2 2 2 0 RsgA GTPase zinc_ribbon_12 PF11331.8 ELR11244.1 - 0.15 11.9 0.1 0.28 11.0 0.1 1.4 1 0 0 1 1 1 0 Probable zinc-ribbon domain Bromodomain PF00439.25 ELR11245.1 - 2.8e-21 75.4 0.0 3.4e-21 75.1 0.0 1.1 1 0 0 1 1 1 1 Bromodomain GCFC PF07842.12 ELR11247.1 - 2.8e-14 53.4 0.0 3.8e-12 46.4 0.0 2.9 1 1 0 1 1 1 1 GC-rich sequence DNA-binding factor-like protein DUF745 PF05335.13 ELR11247.1 - 0.0016 18.2 4.4 0.0042 16.8 4.4 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF745) DUF4763 PF15960.5 ELR11247.1 - 0.018 14.4 5.1 0.037 13.3 5.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4763) NOG1_N PF17835.1 ELR11247.1 - 0.11 12.5 0.3 0.37 10.7 0.2 2.0 2 0 0 2 2 2 0 NOG1 N-terminal helical domain Nup88 PF10168.9 ELR11247.1 - 0.12 10.2 3.0 0.17 9.7 3.0 1.1 1 0 0 1 1 1 0 Nuclear pore component OEP PF02321.18 ELR11247.1 - 0.27 11.0 5.5 1.9 8.3 2.3 2.4 2 0 0 2 2 2 0 Outer membrane efflux protein Prominin PF05478.11 ELR11247.1 - 0.28 9.1 1.9 0.4 8.6 1.9 1.1 1 0 0 1 1 1 0 Prominin GAS PF13851.6 ELR11247.1 - 0.56 9.5 10.0 0.26 10.6 6.4 2.2 1 1 0 1 1 1 0 Growth-arrest specific micro-tubule binding FAM76 PF16046.5 ELR11247.1 - 3 7.1 7.0 5.7 6.2 7.0 1.4 1 0 0 1 1 1 0 FAM76 protein Syntaxin-6_N PF09177.11 ELR11247.1 - 3.8 8.1 6.9 3.1 8.4 1.5 3.3 3 1 0 3 3 3 0 Syntaxin 6, N-terminal zf-RanBP PF00641.18 ELR11248.1 - 1.2e-10 40.5 3.4 3.6e-10 39.0 3.4 1.9 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others IBR PF01485.21 ELR11248.1 - 7.8e-09 35.6 23.7 1.9e-07 31.2 15.3 3.5 2 1 0 2 2 2 1 IBR domain, a half RING-finger domain zf-C3HC4_3 PF13920.6 ELR11248.1 - 0.0048 16.7 3.5 0.0048 16.7 3.5 4.2 4 1 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) NodZ PF05830.11 ELR11248.1 - 0.06 12.2 0.4 0.44 9.3 0.4 2.0 2 0 0 2 2 2 0 Nodulation protein Z (NodZ) Thiolase_C PF02803.18 ELR11249.1 - 3.7e-26 91.2 0.1 1.6e-23 82.6 0.1 2.3 1 1 0 1 1 1 1 Thiolase, C-terminal domain Thiolase_N PF00108.23 ELR11249.1 - 4.1e-17 62.4 0.0 5.5e-17 62.0 0.0 1.2 1 0 0 1 1 1 1 Thiolase, N-terminal domain EGF_2 PF07974.13 ELR11251.1 - 0.0026 18.1 13.7 0.007 16.7 13.7 1.8 1 0 0 1 1 1 1 EGF-like domain EGF PF00008.27 ELR11251.1 - 0.036 14.4 9.6 0.11 12.9 9.6 1.9 1 0 0 1 1 1 0 EGF-like domain Laminin_EGF PF00053.24 ELR11251.1 - 0.054 13.6 6.6 0.14 12.4 6.6 1.6 1 0 0 1 1 1 0 Laminin EGF domain ELO PF01151.18 ELR11252.1 - 2.1e-21 76.6 10.5 2.4e-21 76.4 10.5 1.0 1 0 0 1 1 1 1 GNS1/SUR4 family CBM49 PF09478.10 ELR11254.1 - 3.1e-18 65.9 0.1 2.7e-12 46.8 0.2 2.1 2 0 0 2 2 2 2 Carbohydrate binding domain CBM49 AvrPphF-ORF-2 PF09143.10 ELR11254.1 - 0.075 13.0 0.0 0.12 12.3 0.0 1.3 1 0 0 1 1 1 0 AvrPphF-ORF-2 DUF11 PF01345.18 ELR11254.1 - 0.2 12.0 3.1 1.6 9.1 3.1 2.4 1 1 0 1 1 1 0 Domain of unknown function DUF11 Forkhead PF00250.18 ELR11255.1 - 1.5e-05 25.2 0.0 3.2e-05 24.1 0.0 1.5 1 0 0 1 1 1 1 Forkhead domain PAW PF04721.17 ELR11256.1 - 0.064 13.0 0.2 0.13 12.0 0.0 1.5 2 0 0 2 2 2 0 PNGase C-terminal domain, mannose-binding module PAW Aconitase_C PF00694.19 ELR11257.1 - 8e-39 133.0 0.0 1.3e-38 132.2 0.0 1.4 1 0 0 1 1 1 1 Aconitase C-terminal domain Aconitase PF00330.20 ELR11257.1 - 2.4e-18 66.4 0.1 3.1e-18 66.0 0.1 1.2 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) ADP_PFK_GK PF04587.15 ELR11258.1 - 0.19 10.3 0.0 0.24 9.9 0.0 1.0 1 0 0 1 1 1 0 ADP-specific Phosphofructokinase/Glucokinase conserved region Aconitase PF00330.20 ELR11259.1 - 1.4e-39 136.4 0.1 1.7e-39 136.1 0.1 1.0 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) Spa1_C PF18218.1 ELR11260.1 - 0.14 12.6 0.0 0.25 11.8 0.0 1.4 1 0 0 1 1 1 0 Lantibiotic immunity protein Spa1 C-terminal domain Aconitase PF00330.20 ELR11261.1 - 9.3e-148 493.0 0.0 1.2e-147 492.7 0.0 1.0 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) Romo1 PF10247.9 ELR11262.1 - 9.3e-18 64.4 11.0 1.1e-17 64.1 11.0 1.1 1 0 0 1 1 1 1 Reactive mitochondrial oxygen species modulator 1 Tim17 PF02466.19 ELR11262.1 - 0.0012 19.2 2.3 0.0015 18.9 2.3 1.1 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family Acyl_transf_1 PF00698.21 ELR11263.1 - 3.6e-24 85.8 0.6 4.8e-24 85.4 0.6 1.1 1 0 0 1 1 1 1 Acyl transferase domain Ribosomal_S5 PF00333.20 ELR11263.1 - 0.041 13.9 0.8 1.2 9.1 0.0 2.5 2 0 0 2 2 2 0 Ribosomal protein S5, N-terminal domain Alba PF01918.21 ELR11263.1 - 0.13 12.1 0.1 1.3 8.9 0.4 2.2 2 0 0 2 2 2 0 Alba CsbD PF05532.12 ELR11264.1 - 0.0021 17.9 1.2 0.0056 16.6 1.2 1.8 1 0 0 1 1 1 1 CsbD-like WH2 PF02205.20 ELR11264.1 - 0.015 15.1 0.7 21 5.1 0.0 4.9 5 0 0 5 5 5 0 WH2 motif SIC PF03482.13 ELR11264.1 - 0.24 11.6 0.4 34 4.7 0.0 2.3 2 0 0 2 2 2 0 sic protein repeat CsbD PF05532.12 ELR11268.1 - 0.0016 18.3 1.5 0.0044 16.9 1.5 1.7 1 0 0 1 1 1 1 CsbD-like SIC PF03482.13 ELR11268.1 - 0.25 11.6 0.4 35 4.7 0.0 2.3 2 0 0 2 2 2 0 sic protein repeat Histone PF00125.24 ELR11270.1 - 1.3e-10 41.7 0.9 1.3e-10 41.7 0.9 12.0 4 3 8 13 13 13 1 Core histone H2A/H2B/H3/H4 2OG-FeII_Oxy_2 PF13532.6 ELR11271.1 - 7.2e-21 75.3 0.0 4.4e-20 72.7 0.0 1.9 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy PF03171.20 ELR11271.1 - 0.022 15.2 0.0 0.045 14.2 0.0 1.4 1 0 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily WH2 PF02205.20 ELR11272.1 - 2.4e-07 30.4 10.0 0.14 12.0 0.2 6.0 6 0 0 6 6 6 4 WH2 motif CsbD PF05532.12 ELR11272.1 - 7.1e-06 25.8 6.8 1.5e-05 24.8 6.8 1.5 1 0 0 1 1 1 1 CsbD-like Thymosin PF01290.20 ELR11272.1 - 4.7 7.0 9.5 4.2 7.2 0.4 4.5 5 1 0 5 5 5 0 Thymosin beta-4 family GDPD PF03009.17 ELR11273.1 - 1.1e-36 126.9 0.0 3e-35 122.2 0.0 2.1 1 1 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family GDPD_2 PF13653.6 ELR11273.1 - 0.025 15.0 0.1 0.06 13.8 0.1 1.7 1 0 0 1 1 1 0 Glycerophosphoryl diester phosphodiesterase family DUF2973 PF11189.8 ELR11273.1 - 0.088 12.9 0.1 0.24 11.5 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2973) CsbD PF05532.12 ELR11275.1 - 0.00026 20.8 0.7 0.00051 19.9 0.2 1.6 1 1 0 1 1 1 1 CsbD-like BLOC1S3 PF15753.5 ELR11277.1 - 0.037 14.2 0.7 0.083 13.0 0.7 1.5 1 0 0 1 1 1 0 Biogenesis of lysosome-related organelles complex 1 subunit 3 zf-RanBP PF00641.18 ELR11277.1 - 0.99 8.8 6.2 1.6 8.1 6.2 1.4 1 0 0 1 1 1 0 Zn-finger in Ran binding protein and others MFS_1 PF07690.16 ELR11278.1 - 3.4e-28 98.6 38.7 3.4e-28 98.6 38.7 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 ELR11278.1 - 0.024 13.5 40.2 51 2.5 40.2 2.9 1 1 0 1 1 1 0 Sugar (and other) transporter DUF3511 PF12023.8 ELR11278.1 - 0.19 11.5 0.2 0.36 10.7 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3511) DUF2523 PF10734.9 ELR11278.1 - 0.32 11.6 9.6 0.093 13.3 5.4 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2523) Dyp_perox PF04261.12 ELR11280.1 - 1.5e-36 126.0 0.0 1.9e-36 125.7 0.0 1.1 1 0 0 1 1 1 1 Dyp-type peroxidase family Pro_dh PF01619.18 ELR11281.1 - 4.9e-74 249.5 0.0 5.7e-74 249.3 0.0 1.0 1 0 0 1 1 1 1 Proline dehydrogenase SAP PF02037.27 ELR11282.1 - 0.12 12.2 0.0 1.2 9.0 0.0 2.5 2 0 0 2 2 2 0 SAP domain Vps16_C PF04840.12 ELR11283.1 - 9.8e-22 77.4 1.8 5.5e-11 42.1 0.0 2.1 2 0 0 2 2 2 2 Vps16, C-terminal region N_BRCA1_IG PF16158.5 ELR11285.1 - 8.2e-28 97.1 1.3 1.1e-27 96.7 0.1 1.9 2 0 0 2 2 2 1 Ig-like domain from next to BRCA1 gene PB1 PF00564.24 ELR11285.1 - 1.2e-11 44.4 0.1 2.4e-11 43.4 0.1 1.5 1 0 0 1 1 1 1 PB1 domain PCYCGC PF13798.6 ELR11285.1 - 0.13 12.1 0.0 0.26 11.1 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function with PCYCGC motif BTB PF00651.31 ELR11286.1 - 2.7e-15 56.5 0.0 9.2e-07 29.1 0.0 2.9 2 1 1 3 3 3 2 BTB/POZ domain BACK PF07707.15 ELR11286.1 - 2.6e-07 30.7 0.4 9.8e-06 25.6 0.1 2.3 2 0 0 2 2 2 1 BTB And C-terminal Kelch F5_F8_type_C PF00754.25 ELR11286.1 - 4.2e-07 30.1 0.1 1.1e-06 28.8 0.1 1.7 1 0 0 1 1 1 1 F5/8 type C domain Rrn6 PF10214.9 ELR11286.1 - 0.0016 17.1 5.9 0.0024 16.5 5.9 1.2 1 0 0 1 1 1 1 RNA polymerase I-specific transcription-initiation factor FAM199X PF15814.5 ELR11286.1 - 0.34 9.9 7.3 0.76 8.8 7.3 1.6 1 0 0 1 1 1 0 Protein family FAM199X Med19 PF10278.9 ELR11286.1 - 1.8 8.4 14.7 3.4 7.6 14.7 1.4 1 0 0 1 1 1 0 Mediator of RNA pol II transcription subunit 19 UCR_TM PF02921.14 ELR11286.1 - 5.1 7.6 6.1 15 6.1 6.1 1.7 1 0 0 1 1 1 0 Ubiquinol cytochrome reductase transmembrane region Thioredoxin PF00085.20 ELR11287.1 - 1.4e-57 192.1 0.0 6.9e-28 96.7 0.0 2.4 2 0 0 2 2 2 2 Thioredoxin Thioredoxin_2 PF13098.6 ELR11287.1 - 6.1e-08 33.1 1.1 0.029 14.8 0.1 3.5 2 2 0 2 2 2 2 Thioredoxin-like domain Thioredoxin_3 PF13192.6 ELR11287.1 - 2.9e-05 24.0 0.1 0.5 10.5 0.0 2.9 3 0 0 3 3 3 2 Thioredoxin domain Thioredoxin_8 PF13905.6 ELR11287.1 - 8.4e-05 22.8 0.0 1.1 9.6 0.0 3.6 2 2 1 3 3 3 2 Thioredoxin-like AhpC-TSA PF00578.21 ELR11287.1 - 9.3e-05 22.3 0.7 0.19 11.7 0.1 2.7 3 0 0 3 3 3 2 AhpC/TSA family Thioredoxin_7 PF13899.6 ELR11287.1 - 0.0029 17.8 0.0 2.1 8.6 0.0 2.5 2 0 0 2 2 2 2 Thioredoxin-like Redoxin PF08534.10 ELR11287.1 - 0.0042 16.8 0.3 0.63 9.8 0.1 2.3 2 0 0 2 2 2 1 Redoxin Thioredoxin_9 PF14595.6 ELR11287.1 - 0.015 15.0 0.0 3.8 7.3 0.0 2.5 2 0 0 2 2 2 0 Thioredoxin OST3_OST6 PF04756.13 ELR11287.1 - 0.034 13.5 0.0 2.8 7.2 0.0 2.4 2 0 0 2 2 2 0 OST3 / OST6 family, transporter family Thioredoxin_6 PF13848.6 ELR11287.1 - 0.063 13.2 0.0 1.5 8.7 0.0 2.4 2 0 0 2 2 2 0 Thioredoxin-like domain HyaE PF07449.11 ELR11287.1 - 0.19 11.7 0.0 10 6.1 0.0 2.3 2 0 0 2 2 2 0 Hydrogenase-1 expression protein HyaE TraF PF13728.6 ELR11287.1 - 0.27 11.0 4.4 1.9 8.2 0.0 3.0 3 0 0 3 3 2 0 F plasmid transfer operon protein LapA_dom PF06305.11 ELR11287.1 - 2.4 8.0 4.9 1.3 8.9 0.1 2.3 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain VWA PF00092.28 ELR11288.1 - 2.6e-22 79.9 0.0 1.4e-18 67.8 0.0 2.5 2 0 0 2 2 2 2 von Willebrand factor type A domain VWA_2 PF13519.6 ELR11288.1 - 2.7e-15 56.9 0.1 2.7e-15 56.9 0.1 2.5 3 0 0 3 3 3 1 von Willebrand factor type A domain VWA_3 PF13768.6 ELR11288.1 - 7e-13 48.8 0.0 1.2e-07 31.8 0.0 2.4 2 0 0 2 2 2 2 von Willebrand factor type A domain VWA_CoxE PF05762.14 ELR11288.1 - 1.5e-05 24.5 0.0 3.6e-05 23.3 0.0 1.5 1 0 0 1 1 1 1 VWA domain containing CoxE-like protein Vwaint PF14624.6 ELR11288.1 - 3.4e-05 23.9 0.6 7.4e-05 22.8 0.6 1.6 1 0 0 1 1 1 1 VWA / Hh protein intein-like DUF2201 PF09967.9 ELR11288.1 - 0.12 12.5 0.0 0.29 11.3 0.0 1.7 1 1 0 1 1 1 0 VWA-like domain (DUF2201) DUF444 PF04285.12 ELR11288.1 - 0.21 10.6 0.1 0.21 10.6 0.1 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF444) Voltage_CLC PF00654.20 ELR11289.1 - 4.7e-67 226.7 20.2 4.7e-67 226.7 20.2 1.9 1 1 1 2 2 2 1 Voltage gated chloride channel Rhodanese PF00581.20 ELR11289.1 - 5.6e-22 78.3 0.0 2.5e-13 50.5 0.0 2.4 2 0 0 2 2 2 2 Rhodanese-like domain CBS PF00571.28 ELR11289.1 - 7e-08 32.8 0.0 0.026 15.0 0.0 3.0 2 1 0 2 2 2 2 CBS domain SnoaL_2 PF12680.7 ELR11290.1 - 7.4e-05 23.3 0.0 0.00011 22.8 0.0 1.3 1 0 0 1 1 1 1 SnoaL-like domain SnoaL_4 PF13577.6 ELR11290.1 - 0.00099 19.2 0.0 0.0013 18.9 0.0 1.2 1 0 0 1 1 1 1 SnoaL-like domain DUF4440 PF14534.6 ELR11290.1 - 0.12 12.7 0.0 0.17 12.3 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4440) DFRP_C PF16543.5 ELR11291.1 - 1.2e-16 60.9 6.9 1.2e-16 60.9 6.9 3.8 4 1 1 5 5 5 1 DRG Family Regulatory Proteins, Tma46 zf-CCCH PF00642.24 ELR11291.1 - 1.2e-06 28.3 0.9 1.2e-06 28.3 0.9 2.3 3 0 0 3 3 3 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Torus PF16131.5 ELR11291.1 - 1.4e-06 29.0 13.7 4.6e-05 24.1 3.8 4.1 2 1 1 3 3 3 2 Torus domain zf_CCCH_4 PF18345.1 ELR11291.1 - 2.5e-06 27.3 6.7 2.5e-06 27.3 6.7 3.0 3 0 0 3 3 3 1 Zinc finger domain zf-CCCH_4 PF18044.1 ELR11291.1 - 7.8e-06 25.6 1.8 7.8e-06 25.6 1.8 2.7 3 0 0 3 3 3 1 CCCH-type zinc finger zf-CCCH_3 PF15663.5 ELR11291.1 - 0.0011 19.2 2.6 0.017 15.3 0.2 2.9 3 0 0 3 3 3 1 Zinc-finger containing family Nuc_deoxyri_tr2 PF15891.5 ELR11291.1 - 0.034 14.4 0.5 0.3 11.4 0.0 2.4 2 0 0 2 2 2 0 Nucleoside 2-deoxyribosyltransferase like zf-CCCH_2 PF14608.6 ELR11291.1 - 0.89 10.1 16.3 3 8.4 5.2 3.0 2 1 0 2 2 2 0 RNA-binding, Nab2-type zinc finger MKT1_C PF12246.8 ELR11292.1 - 3.2e-49 167.3 0.0 6.1e-49 166.4 0.0 1.5 1 0 0 1 1 1 1 Temperature dependent protein affecting M2 dsRNA replication MKT1_N PF12247.8 ELR11292.1 - 6.5e-24 84.1 0.0 1.7e-23 82.8 0.0 1.8 1 0 0 1 1 1 1 Temperature dependent protein affecting M2 dsRNA replication XPG_N PF00752.17 ELR11292.1 - 4.4e-06 27.1 0.0 9.4e-06 26.0 0.0 1.6 1 0 0 1 1 1 1 XPG N-terminal domain XPG_I PF00867.18 ELR11292.1 - 0.004 17.5 0.0 0.0091 16.3 0.0 1.6 1 0 0 1 1 1 1 XPG I-region Not1 PF04054.15 ELR11293.1 - 5.2e-149 496.2 2.0 1.3e-148 494.9 2.0 1.7 1 0 0 1 1 1 1 CCR4-Not complex component, Not1 CNOT1_CAF1_bind PF16415.5 ELR11293.1 - 1.1e-87 293.1 5.9 8.5e-87 290.2 1.8 2.6 2 0 0 2 2 2 1 CCR4-NOT transcription complex subunit 1 CAF1-binding domain CNOT1_TTP_bind PF16417.5 ELR11293.1 - 5.4e-73 244.2 0.2 1.1e-71 239.9 0.0 2.9 2 0 0 2 2 2 1 CCR4-NOT transcription complex subunit 1 TTP binding domain DUF3819 PF12842.7 ELR11293.1 - 9e-55 184.6 8.4 2.7e-54 183.1 8.4 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF3819) CNOT1_HEAT PF16418.5 ELR11293.1 - 4.3e-45 153.4 0.2 1.6e-44 151.6 0.2 2.1 1 0 0 1 1 1 1 CCR4-NOT transcription complex subunit 1 HEAT repeat DUF2420 PF10336.9 ELR11293.1 - 0.63 10.1 2.3 0.61 10.1 0.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2420) Translin PF01997.16 ELR11294.1 - 5.1e-54 183.4 0.0 6.2e-54 183.1 0.0 1.1 1 0 0 1 1 1 1 Translin family MAM33 PF02330.16 ELR11295.1 - 2.2e-13 50.7 10.0 3.8e-13 49.9 10.0 1.4 1 0 0 1 1 1 1 Mitochondrial glycoprotein Na_trans_assoc PF06512.13 ELR11295.1 - 0.082 13.2 6.9 0.11 12.8 6.9 1.3 1 0 0 1 1 1 0 Sodium ion transport-associated DUF809 PF05663.11 ELR11295.1 - 0.46 10.6 5.9 0.76 9.9 5.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF809) SDA1 PF05285.12 ELR11295.1 - 2 7.8 19.5 2.5 7.4 19.5 1.2 1 0 0 1 1 1 0 SDA1 Nop14 PF04147.12 ELR11295.1 - 3.6 5.7 20.3 4.2 5.5 20.3 1.1 1 0 0 1 1 1 0 Nop14-like family BTB PF00651.31 ELR11296.1 - 1.9e-18 66.7 0.0 2.9e-10 40.3 0.0 3.5 2 1 1 3 3 3 3 BTB/POZ domain CDC45 PF02724.14 ELR11296.1 - 0.84 7.9 8.5 1.5 7.0 8.5 1.3 1 0 0 1 1 1 0 CDC45-like protein Methyltransf_24 PF13578.6 ELR11297.1 - 1.4e-12 48.5 0.1 2.3e-12 47.9 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase domain Orn_Arg_deC_N PF02784.16 ELR11298.1 - 8.6e-33 113.7 0.0 2e-32 112.5 0.0 1.5 1 1 0 1 1 1 1 Pyridoxal-dependent decarboxylase, pyridoxal binding domain Orn_DAP_Arg_deC PF00278.22 ELR11298.1 - 1.6e-20 73.1 0.0 1.7e-20 73.1 0.0 1.2 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, C-terminal sheet domain RhoGEF PF00621.20 ELR11300.1 - 3.1e-47 161.2 6.9 4.2e-46 157.5 4.1 3.1 2 1 0 2 2 2 1 RhoGEF domain Dynamin_N PF00350.23 ELR11300.1 - 1.1e-12 48.3 0.2 3.3e-11 43.5 0.0 3.2 2 1 0 2 2 2 1 Dynamin family PH_13 PF16652.5 ELR11300.1 - 7.2e-05 22.6 0.3 7.2e-05 22.6 0.3 3.2 3 0 0 3 3 3 1 Pleckstrin homology domain MMR_HSR1 PF01926.23 ELR11300.1 - 0.0007 19.7 0.0 1.1 9.4 0.0 3.0 2 0 0 2 2 2 2 50S ribosome-binding GTPase DUF5077 PF16871.5 ELR11300.1 - 0.021 14.7 0.3 0.051 13.5 0.3 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF5077) RsgA_GTPase PF03193.16 ELR11300.1 - 0.046 13.6 1.6 0.68 9.8 0.0 3.2 3 0 0 3 3 3 0 RsgA GTPase AAA_14 PF13173.6 ELR11300.1 - 0.08 13.0 0.0 0.42 10.7 0.0 2.3 1 0 0 1 1 1 0 AAA domain IQ_SEC7_PH PF16453.5 ELR11300.1 - 0.081 12.9 1.4 0.23 11.5 0.3 2.4 2 0 0 2 2 2 0 PH domain ABC_tran PF00005.27 ELR11300.1 - 0.1 13.1 0.1 0.1 13.1 0.1 2.3 2 0 0 2 2 2 0 ABC transporter AAA_23 PF13476.6 ELR11300.1 - 0.13 12.7 0.0 0.13 12.7 0.0 4.2 5 0 0 5 5 5 0 AAA domain MIP PF00230.20 ELR11301.1 - 7.9e-25 87.9 11.9 2.1e-24 86.5 11.9 1.6 1 1 0 1 1 1 1 Major intrinsic protein LETM1 PF07766.13 ELR11302.1 - 4e-70 236.2 13.8 4e-70 236.2 13.8 3.6 2 2 0 2 2 1 1 LETM1-like protein EF-hand_7 PF13499.6 ELR11302.1 - 1.6e-14 54.1 4.0 5.2e-10 39.6 0.3 3.3 3 1 1 4 4 3 2 EF-hand domain pair EF-hand_1 PF00036.32 ELR11302.1 - 2.8e-13 48.4 0.4 5.6e-06 25.5 0.0 3.4 3 0 0 3 3 3 2 EF hand EF-hand_8 PF13833.6 ELR11302.1 - 3.3e-13 49.3 0.4 2.3e-09 37.0 0.0 2.6 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 ELR11302.1 - 4.8e-10 38.5 0.1 1.9e-05 24.0 0.0 2.6 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 ELR11302.1 - 1.7e-08 33.7 0.0 0.0061 16.4 0.0 2.8 2 0 0 2 2 2 2 EF-hand domain PriCT_2 PF08707.11 ELR11302.1 - 0.1 13.0 0.0 0.24 11.8 0.0 1.7 1 0 0 1 1 1 0 Primase C terminal 2 (PriCT-2) DUF2755 PF10954.8 ELR11302.1 - 0.15 12.0 0.0 0.37 10.7 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2755) SPARC_Ca_bdg PF10591.9 ELR11302.1 - 0.18 12.1 12.3 1.8 8.9 0.1 3.9 2 1 1 3 3 3 0 Secreted protein acidic and rich in cysteine Ca binding region PspB PF06667.12 ELR11302.1 - 2.6 8.2 5.3 0.97 9.5 0.3 3.0 3 0 0 3 3 3 0 Phage shock protein B DUF4337 PF14235.6 ELR11302.1 - 9.1 6.4 28.5 3.4 7.7 4.3 4.0 2 1 1 3 3 2 0 Domain of unknown function (DUF4337) Methyltr_RsmB-F PF01189.17 ELR11303.1 - 4.4e-32 111.4 0.0 1.5e-22 80.2 0.0 3.1 2 1 0 2 2 2 2 16S rRNA methyltransferase RsmB/F FtsJ PF01728.19 ELR11303.1 - 0.015 15.4 0.0 0.028 14.5 0.0 1.5 1 1 0 1 1 1 0 FtsJ-like methyltransferase Ribosomal_60s PF00428.19 ELR11303.1 - 2.1 9.0 16.8 4.6 7.9 16.8 1.5 1 0 0 1 1 1 0 60s Acidic ribosomal protein GYF PF02213.16 ELR11305.1 - 7.3e-16 57.6 0.1 1.5e-15 56.6 0.1 1.6 1 0 0 1 1 1 1 GYF domain GYF_2 PF14237.6 ELR11305.1 - 0.0043 16.8 0.0 0.019 14.8 0.0 2.3 1 0 0 1 1 1 1 GYF domain 2 BCIP PF13862.6 ELR11306.1 - 2.8e-45 154.7 0.7 3.8e-25 88.9 0.2 3.3 2 1 0 2 2 2 2 p21-C-terminal region-binding protein FAD_binding_1 PF00667.20 ELR11306.1 - 0.00039 20.0 0.0 0.00062 19.4 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain SDA1 PF05285.12 ELR11306.1 - 2.4 7.5 16.6 3.5 6.9 16.6 1.3 1 0 0 1 1 1 0 SDA1 INCENP_ARK-bind PF03941.15 ELR11307.1 - 0.00033 20.5 2.0 0.021 14.7 0.1 3.0 3 0 0 3 3 3 2 Inner centromere protein, ARK binding region Hva1_TUDOR PF11160.8 ELR11308.1 - 2.4e-19 69.2 1.1 2.4e-19 69.2 1.1 2.2 2 1 0 2 2 2 1 Hypervirulence associated proteins TUDOR domain U79_P34 PF03064.16 ELR11308.1 - 4 6.7 13.0 4.4 6.6 13.0 1.1 1 0 0 1 1 1 0 HSV U79 / HCMV P34 Glyco_hydro_8 PF01270.17 ELR11310.1 - 1.8e-20 73.1 6.5 3.8e-20 72.0 6.5 1.5 1 1 0 1 1 1 1 Glycosyl hydrolases family 8 CysG_dimeriser PF10414.9 ELR11310.1 - 0.14 11.9 0.6 1.8 8.4 0.7 2.6 2 0 0 2 2 2 0 Sirohaem synthase dimerisation region DEAD PF00270.29 ELR11311.1 - 4.5e-27 94.9 0.1 6.4e-27 94.4 0.1 1.2 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_19 PF13245.6 ELR11311.1 - 0.0019 18.5 0.7 0.0036 17.7 0.8 1.4 1 1 0 1 1 1 1 AAA domain ResIII PF04851.15 ELR11311.1 - 0.0024 17.9 0.0 0.0048 16.9 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit UvrD-helicase PF00580.21 ELR11311.1 - 0.0044 16.6 0.2 0.0062 16.1 0.2 1.2 1 0 0 1 1 1 1 UvrD/REP helicase N-terminal domain AAA_30 PF13604.6 ELR11311.1 - 0.021 14.5 0.0 0.032 14.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain CobA_CobO_BtuR PF02572.15 ELR11311.1 - 0.028 14.7 0.1 0.048 13.9 0.1 1.4 1 1 0 1 1 1 0 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP Cytochrome-c551 PF10643.9 ELR11312.1 - 2.4 7.7 7.5 3.6 7.1 7.5 1.2 1 0 0 1 1 1 0 Photosystem P840 reaction-centre cytochrome c-551 DUF4199 PF13858.6 ELR11312.1 - 7.4 6.9 10.1 14 6.0 10.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4199) Usp PF00582.26 ELR11313.1 - 6.1e-23 81.9 0.0 7.6e-23 81.6 0.0 1.1 1 0 0 1 1 1 1 Universal stress protein family Glycos_transf_1 PF00534.20 ELR11314.1 - 1.1e-11 44.5 0.0 3.2e-11 43.1 0.0 1.7 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 ELR11314.1 - 4.1e-11 43.4 0.0 1.1e-10 42.0 0.0 1.6 1 1 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_2 PF13524.6 ELR11314.1 - 1e-05 25.8 0.0 2.7e-05 24.5 0.0 1.6 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glycogen_syn PF05693.13 ELR11314.1 - 0.02 13.4 0.0 0.029 13.0 0.0 1.1 1 0 0 1 1 1 0 Glycogen synthase Inh PF02974.14 ELR11314.1 - 0.039 14.0 0.0 0.076 13.1 0.0 1.4 1 0 0 1 1 1 0 Protease inhibitor Inh HEM4 PF02602.15 ELR11315.1 - 1.5e-36 126.0 0.0 2.1e-36 125.4 0.0 1.2 1 0 0 1 1 1 1 Uroporphyrinogen-III synthase HemD ACPS PF01648.20 ELR11316.1 - 1.1e-16 60.9 0.0 1.2e-16 60.8 0.0 1.0 1 0 0 1 1 1 1 4'-phosphopantetheinyl transferase superfamily 4PPT_N PF17837.1 ELR11316.1 - 1.3 9.2 4.3 11 6.2 0.1 2.3 2 0 0 2 2 2 0 4'-phosphopantetheinyl transferase N-terminal domain TRAM_LAG1_CLN8 PF03798.16 ELR11318.1 - 1.7e-25 89.9 19.6 1.7e-25 89.9 19.6 2.2 1 1 0 2 2 2 1 TLC domain TRAM1 PF08390.11 ELR11318.1 - 0.019 14.6 0.8 0.064 12.9 0.0 2.3 2 0 0 2 2 2 0 TRAM1-like protein Mito_carr PF00153.27 ELR11319.1 - 1.1e-49 166.3 1.1 1.3e-18 66.7 0.1 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein DUF5576 PF17739.1 ELR11319.1 - 0.024 14.7 0.5 9 6.4 0.0 2.6 3 0 0 3 3 3 0 Family of unknown function (DUF5576) TM2 PF05154.16 ELR11320.1 - 3.4e-14 52.9 3.0 3.4e-14 52.9 3.0 2.2 2 0 0 2 2 2 1 TM2 domain EGF_2 PF07974.13 ELR11320.1 - 0.00013 22.3 11.8 0.00013 22.3 11.8 2.5 2 1 0 2 2 2 1 EGF-like domain EGF PF00008.27 ELR11320.1 - 0.00077 19.7 8.2 0.00077 19.7 8.2 2.1 2 0 0 2 2 2 1 EGF-like domain Herpes_UL87 PF03043.14 ELR11320.1 - 0.026 13.0 0.0 0.036 12.5 0.0 1.1 1 0 0 1 1 1 0 Herpesvirus UL87 family hEGF PF12661.7 ELR11320.1 - 5.5 7.8 19.1 0.33 11.7 8.3 3.4 3 0 0 3 3 3 0 Human growth factor-like EGF Synapsin_C PF02750.14 ELR11321.1 - 8.7e-50 169.1 0.0 1.1e-49 168.7 0.0 1.1 1 0 0 1 1 1 1 Synapsin, ATP binding domain Synapsin PF02078.16 ELR11321.1 - 1.8e-15 57.0 0.0 9.1e-15 54.8 0.0 2.2 3 0 0 3 3 3 1 Synapsin, N-terminal domain Med19 PF10278.9 ELR11321.1 - 6.8 6.6 12.0 10 6.0 12.0 1.2 1 0 0 1 1 1 0 Mediator of RNA pol II transcription subunit 19 CN_hydrolase PF00795.22 ELR11322.1 - 1.9e-62 211.0 0.0 2.3e-62 210.7 0.0 1.0 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase Par3_HAL_N_term PF12053.8 ELR11323.1 - 0.00014 22.0 0.2 0.00019 21.6 0.2 1.2 1 0 0 1 1 1 1 N-terminal of Par3 and HAL proteins ABC_tran PF00005.27 ELR11324.1 - 3e-22 79.6 0.0 8e-21 75.0 0.0 2.3 1 1 0 1 1 1 1 ABC transporter ABC2_membrane_3 PF12698.7 ELR11324.1 - 1.5e-14 53.9 28.3 1.5e-14 53.9 28.3 1.5 2 0 0 2 2 2 1 ABC-2 family transporter protein AAA_21 PF13304.6 ELR11324.1 - 2.4e-08 34.2 0.8 3.3e-08 33.7 0.0 1.6 2 0 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system SbcCD_C PF13558.6 ELR11324.1 - 0.063 13.5 0.0 0.15 12.3 0.0 1.7 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit AAA_15 PF13175.6 ELR11324.1 - 0.18 11.5 0.0 0.28 10.8 0.0 1.2 1 0 0 1 1 1 0 AAA ATPase domain EGF PF00008.27 ELR11326.1 - 0.00042 20.6 7.2 0.00085 19.6 7.2 1.5 1 0 0 1 1 1 1 EGF-like domain EGF_2 PF07974.13 ELR11326.1 - 0.001 19.4 8.6 0.0019 18.5 8.6 1.4 1 0 0 1 1 1 1 EGF-like domain EGF_alliinase PF04863.13 ELR11326.1 - 4.7 7.7 10.5 0.19 12.2 3.9 2.0 2 0 0 2 2 2 0 Alliinase EGF-like domain Rtt106 PF08512.12 ELR11327.1 - 0.0012 19.2 0.0 0.0023 18.3 0.0 1.4 1 0 0 1 1 1 1 Histone chaperone Rttp106-like PBP1_TM PF14812.6 ELR11327.1 - 0.019 15.3 5.9 0.019 15.3 5.9 7.8 5 2 1 6 6 6 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Beta-lactamase PF00144.24 ELR11328.1 - 4.7e-37 128.0 0.0 7e-37 127.4 0.0 1.1 1 0 0 1 1 1 1 Beta-lactamase Peptidase_S11 PF00768.20 ELR11328.1 - 0.018 14.5 0.0 0.045 13.2 0.0 1.5 2 0 0 2 2 2 0 D-alanyl-D-alanine carboxypeptidase Usp PF00582.26 ELR11329.1 - 0.062 13.8 0.5 0.08 13.5 0.2 1.5 2 0 0 2 2 2 0 Universal stress protein family TFIIE-A_C PF11521.8 ELR11329.1 - 1.8 8.9 9.2 18 5.7 9.2 2.1 1 1 0 1 1 1 0 C-terminal general transcription factor TFIIE alpha HSP70 PF00012.20 ELR11330.1 - 3.1e-17 62.0 7.3 3.6e-15 55.2 0.1 2.0 1 1 1 2 2 2 2 Hsp70 protein AAA_21 PF13304.6 ELR11330.1 - 0.026 14.3 0.2 0.032 14.1 0.2 1.1 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system zf-UBP_var PF17807.1 ELR11331.1 - 3e-25 87.8 0.0 6.9e-24 83.4 0.0 2.3 2 0 0 2 2 2 1 Variant UBP zinc finger zf-UBP PF02148.19 ELR11331.1 - 8.4e-14 51.7 0.0 2.3e-13 50.3 0.0 1.8 1 0 0 1 1 1 1 Zn-finger in ubiquitin-hydrolases and other protein UCH PF00443.29 ELR11331.1 - 3.5e-07 30.0 0.2 7e-07 29.0 0.1 1.5 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase NAD_binding_10 PF13460.6 ELR11332.1 - 1.9e-38 132.2 1.2 2.4e-38 131.9 1.2 1.1 1 0 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 ELR11332.1 - 2.4e-12 46.9 0.1 3.1e-12 46.5 0.1 1.2 1 0 0 1 1 1 1 NmrA-like family 3Beta_HSD PF01073.19 ELR11332.1 - 1.1e-09 37.7 0.1 1.6e-09 37.2 0.1 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 ELR11332.1 - 6.5e-08 32.3 0.3 1.5e-07 31.1 0.3 1.6 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.12 ELR11332.1 - 4.7e-05 22.7 3.5 0.013 14.7 3.5 2.8 1 1 0 1 1 1 1 Male sterility protein KR PF08659.10 ELR11332.1 - 8.6e-05 22.5 2.3 0.0023 17.9 0.3 2.3 2 0 0 2 2 2 1 KR domain RmlD_sub_bind PF04321.17 ELR11332.1 - 0.0049 16.0 0.5 0.029 13.5 0.1 2.2 2 1 0 2 2 2 1 RmlD substrate binding domain adh_short PF00106.25 ELR11332.1 - 0.0067 15.9 0.8 0.01 15.3 0.1 1.6 2 0 0 2 2 2 1 short chain dehydrogenase Sacchrp_dh_NADP PF03435.18 ELR11332.1 - 0.0076 16.5 0.2 0.014 15.7 0.2 1.4 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain Polysacc_synt_2 PF02719.15 ELR11332.1 - 0.016 14.4 0.2 0.044 12.9 0.2 1.7 1 1 0 1 1 1 0 Polysaccharide biosynthesis protein TrkA_N PF02254.18 ELR11332.1 - 0.018 15.3 0.1 0.038 14.2 0.1 1.5 1 0 0 1 1 1 0 TrkA-N domain GDP_Man_Dehyd PF16363.5 ELR11332.1 - 0.024 14.0 0.0 0.035 13.5 0.0 1.3 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase RasGEF PF00617.19 ELR11333.1 - 6.9e-58 195.8 0.2 2e-57 194.2 0.2 1.9 2 0 0 2 2 2 1 RasGEF domain LRR_8 PF13855.6 ELR11333.1 - 5.8e-33 112.5 37.5 5.2e-10 38.9 2.1 6.5 4 1 3 7 7 7 7 Leucine rich repeat LRR_4 PF12799.7 ELR11333.1 - 1e-22 79.8 37.8 7.9e-05 22.9 1.6 7.9 5 1 6 11 11 11 9 Leucine Rich repeats (2 copies) RasGEF_N PF00618.20 ELR11333.1 - 3e-13 49.9 0.0 9.4e-13 48.3 0.0 1.9 1 0 0 1 1 1 1 RasGEF N-terminal motif LRR_5 PF13306.6 ELR11333.1 - 0.00024 21.0 0.2 0.00058 19.8 0.2 1.7 1 0 0 1 1 1 1 BspA type Leucine rich repeat region (6 copies) LRR_9 PF14580.6 ELR11333.1 - 0.0077 15.8 20.8 0.021 14.4 1.1 4.9 2 2 3 5 5 5 3 Leucine-rich repeat LRR_1 PF00560.33 ELR11333.1 - 0.23 12.2 27.1 5.2 8.0 0.1 9.3 10 1 0 10 10 10 0 Leucine Rich Repeat PTEN_C2 PF10409.9 ELR11334.1 - 2.3e-06 27.4 0.0 3.3e-06 26.9 0.0 1.1 1 0 0 1 1 1 1 C2 domain of PTEN tumour-suppressor protein Pkinase PF00069.25 ELR11335.1 - 3.4e-66 223.3 0.0 6.8e-66 222.3 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR11335.1 - 7.6e-34 117.2 0.0 1.3e-33 116.4 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase PAS_9 PF13426.7 ELR11335.1 - 1.9e-24 85.9 0.2 1.8e-08 34.6 0.0 3.8 2 1 1 3 3 3 3 PAS domain PAS PF00989.25 ELR11335.1 - 5.4e-24 84.4 0.4 1.1e-06 28.6 0.0 3.6 2 1 1 3 3 3 3 PAS fold Kinase-like PF14531.6 ELR11335.1 - 2.4e-07 30.4 0.0 4.5e-07 29.5 0.0 1.4 1 0 0 1 1 1 1 Kinase-like PAS_4 PF08448.10 ELR11335.1 - 3.6e-07 30.4 0.0 0.01 16.1 0.0 3.6 3 0 0 3 3 3 2 PAS fold PAS_3 PF08447.12 ELR11335.1 - 3.3e-06 27.3 0.1 0.14 12.5 0.1 3.9 3 0 0 3 3 3 2 PAS fold Kdo PF06293.14 ELR11335.1 - 4.8e-06 26.1 0.3 1.4e-05 24.6 0.3 1.8 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family PAS_8 PF13188.7 ELR11335.1 - 2.6e-05 24.1 0.0 0.13 12.3 0.0 3.9 4 0 0 4 4 4 1 PAS domain RIO1 PF01163.22 ELR11335.1 - 3.4e-05 23.5 0.4 7.8e-05 22.3 0.4 1.5 1 0 0 1 1 1 1 RIO1 family Haspin_kinase PF12330.8 ELR11335.1 - 4.9e-05 22.4 1.2 0.00026 20.1 1.3 1.9 1 1 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 ELR11335.1 - 0.00025 21.0 1.0 0.0037 17.2 0.3 2.2 1 1 1 2 2 2 1 Phosphotransferase enzyme family RNA_polI_A34 PF08208.11 ELR11335.1 - 2 8.5 15.0 3.6 7.6 15.0 1.4 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 RRM_1 PF00076.22 ELR11336.1 - 8.7e-06 25.5 0.0 1.4e-05 24.9 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Kelch_5 PF13854.6 ELR11337.1 - 2e-19 69.1 0.2 3e-09 36.6 0.0 2.5 2 0 0 2 2 2 2 Kelch motif Kelch_2 PF07646.15 ELR11337.1 - 8.5e-18 63.6 0.8 1e-07 31.6 0.1 2.6 2 0 0 2 2 2 2 Kelch motif Kelch_1 PF01344.25 ELR11337.1 - 3e-17 61.9 0.8 1.3e-08 34.3 0.1 2.2 2 0 0 2 2 2 2 Kelch motif Kelch_4 PF13418.6 ELR11337.1 - 3.7e-14 52.5 1.3 7.9e-06 25.8 0.2 2.5 2 0 0 2 2 2 2 Galactose oxidase, central domain Kelch_6 PF13964.6 ELR11337.1 - 5.5e-12 45.5 0.2 2.1e-05 24.6 0.0 2.4 2 0 0 2 2 2 2 Kelch motif Kelch_3 PF13415.6 ELR11337.1 - 7.8e-12 45.2 1.9 5.5e-05 23.3 0.0 3.3 3 0 0 3 3 3 2 Galactose oxidase, central domain BTB_2 PF02214.22 ELR11337.1 - 4.6e-08 33.3 0.0 7.5e-08 32.6 0.0 1.3 1 0 0 1 1 1 1 BTB/POZ domain RAG2 PF03089.14 ELR11337.1 - 0.0025 16.8 0.1 0.08 11.9 0.0 2.1 1 1 1 2 2 2 1 Recombination activating protein 2 CLIP1_ZNF PF16641.5 ELR11337.1 - 0.11 12.4 1.0 21 5.1 0.0 2.9 3 0 0 3 3 3 0 CLIP1 zinc knuckle zf-CCHC PF00098.23 ELR11337.1 - 0.96 9.6 5.6 25 5.2 0.2 3.2 3 0 0 3 3 3 0 Zinc knuckle SHS2_Rpb7-N PF03876.17 ELR11338.1 - 7.5e-15 55.1 0.0 1.1e-14 54.5 0.0 1.3 1 0 0 1 1 1 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 S1 PF00575.23 ELR11338.1 - 2.2e-11 43.9 0.1 4.1e-11 43.1 0.1 1.5 1 0 0 1 1 1 1 S1 RNA binding domain RNA_pol_Rbc25 PF08292.12 ELR11338.1 - 0.00037 20.7 0.1 0.0018 18.5 0.0 2.1 2 1 0 2 2 2 1 RNA polymerase III subunit Rpc25 GST_N_2 PF13409.6 ELR11339.1 - 2.7e-09 37.2 0.0 4.7e-09 36.4 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 ELR11339.1 - 5.2e-08 33.2 0.0 1.1e-07 32.1 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain MHCassoc_trimer PF08831.10 ELR11339.1 - 0.044 13.8 0.4 0.11 12.5 0.3 1.7 1 1 1 2 2 2 0 Class II MHC-associated invariant chain trimerisation domain RhoGAP PF00620.27 ELR11340.1 - 5e-23 81.6 1.2 1.2e-22 80.3 0.1 2.3 3 0 0 3 3 3 1 RhoGAP domain BAR_3 PF16746.5 ELR11340.1 - 1.1e-12 48.2 10.1 1.1e-12 48.2 10.1 1.6 2 0 0 2 2 2 1 BAR domain of APPL family TraO PF10626.9 ELR11340.1 - 0.024 14.4 0.7 0.037 13.8 0.7 1.2 1 0 0 1 1 1 0 Conjugative transposon protein TraO Mt_ATP-synt_D PF05873.12 ELR11340.1 - 0.047 13.5 4.3 0.11 12.4 4.3 1.6 1 0 0 1 1 1 0 ATP synthase D chain, mitochondrial (ATP5H) AAA_13 PF13166.6 ELR11340.1 - 0.071 11.8 2.8 0.12 11.0 2.8 1.2 1 0 0 1 1 1 0 AAA domain BAR_2 PF10455.9 ELR11340.1 - 2 7.5 9.1 0.84 8.7 5.9 1.9 2 0 0 2 2 2 0 Bin/amphiphysin/Rvs domain for vesicular trafficking IFT57 PF10498.9 ELR11340.1 - 2.6 6.9 7.3 4.7 6.1 7.3 1.4 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 STAT_int PF02865.17 ELR11341.1 - 0.11 12.9 0.1 0.12 12.8 0.1 1.0 1 0 0 1 1 1 0 STAT protein, protein interaction domain Acyl-CoA_ox_N PF14749.6 ELR11342.1 - 2e-05 25.2 0.0 2.5e-05 24.8 0.0 1.2 1 0 0 1 1 1 1 Acyl-coenzyme A oxidase N-terminal CARDB PF07705.11 ELR11343.1 - 6e-05 23.2 1.1 0.045 14.0 0.7 4.0 3 3 0 3 3 3 1 CARDB DBD_HTH PF18430.1 ELR11343.1 - 0.043 13.6 0.0 4.7 7.1 0.0 2.5 2 0 0 2 2 2 0 Putative DNA-binding domain SKG6 PF08693.10 ELR11343.1 - 1.9 8.0 5.9 4.8 6.7 5.9 1.7 1 0 0 1 1 1 0 Transmembrane alpha-helix domain VIR_N PF15912.5 ELR11344.1 - 0.075 12.6 7.8 0.091 12.3 7.8 1.0 1 0 0 1 1 1 0 Virilizer, N-terminal PRP38_assoc PF12871.7 ELR11344.1 - 0.076 13.6 32.9 0.12 13.0 32.9 1.3 1 0 0 1 1 1 0 Pre-mRNA-splicing factor 38-associated hydrophilic C-term SWIRM-assoc_2 PF16496.5 ELR11344.1 - 0.65 8.8 7.7 0.7 8.7 7.7 1.2 1 0 0 1 1 1 0 SWIRM-associated domain at the N-terminal CUE PF02845.16 ELR11345.1 - 4e-09 36.0 0.0 7.3e-09 35.2 0.0 1.4 1 0 0 1 1 1 1 CUE domain zf-RING_2 PF13639.6 ELR11345.1 - 0.00032 21.0 0.5 0.0006 20.1 0.5 1.4 1 0 0 1 1 1 1 Ring finger domain zf-RING_11 PF17123.5 ELR11345.1 - 0.00058 19.5 2.5 0.0011 18.7 2.5 1.5 1 0 0 1 1 1 1 RING-like zinc finger zf-RING_UBOX PF13445.6 ELR11345.1 - 0.0027 17.7 0.4 0.0051 16.8 0.4 1.4 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 ELR11345.1 - 0.012 15.4 1.0 0.022 14.6 1.0 1.3 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 ELR11345.1 - 0.15 11.9 2.0 0.26 11.2 2.0 1.3 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) PRP38_assoc PF12871.7 ELR11346.1 - 0.031 14.9 33.1 0.043 14.4 33.1 1.3 1 0 0 1 1 1 0 Pre-mRNA-splicing factor 38-associated hydrophilic C-term SWIRM-assoc_2 PF16496.5 ELR11346.1 - 0.69 8.7 9.4 0.76 8.6 9.4 1.0 1 0 0 1 1 1 0 SWIRM-associated domain at the N-terminal TIM PF00121.18 ELR11347.1 - 9.1e-44 149.6 0.0 1.2e-43 149.3 0.0 1.1 1 0 0 1 1 1 1 Triosephosphate isomerase zf-SNAP50_C PF12251.8 ELR11348.1 - 3e-44 151.1 2.8 3.5e-44 150.9 2.8 1.0 1 0 0 1 1 1 1 snRNA-activating protein of 50kDa MW C terminal Ribosomal_L21e PF01157.18 ELR11349.1 - 1.7e-21 76.0 2.7 3.8e-20 71.6 0.7 2.0 2 0 0 2 2 2 2 Ribosomal protein L21e SepSecS PF05889.13 ELR11349.1 - 0.0065 15.2 0.0 0.011 14.5 0.0 1.4 1 1 0 1 1 1 1 O-phosphoseryl-tRNA(Sec) selenium transferase, SepSecS Lactamase_B_6 PF16661.5 ELR11350.1 - 0.0017 17.8 0.0 0.0077 15.7 0.0 1.9 2 0 0 2 2 2 1 Metallo-beta-lactamase superfamily domain DUF364 PF04016.12 ELR11352.1 - 0.13 11.8 0.0 0.21 11.1 0.0 1.3 1 0 0 1 1 1 0 Putative heavy-metal chelation BTB_2 PF02214.22 ELR11354.1 - 0.0014 18.9 0.0 0.0021 18.3 0.0 1.2 1 0 0 1 1 1 1 BTB/POZ domain dCMP_cyt_deam_1 PF00383.23 ELR11355.1 - 9.7e-29 99.2 0.0 1.5e-28 98.6 0.0 1.3 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 ELR11355.1 - 3.6e-12 46.2 0.0 4.4e-12 45.9 0.0 1.1 1 0 0 1 1 1 1 MafB19-like deaminase RACo_linker PF17650.1 ELR11358.1 - 0.051 13.4 0.0 1.4 8.9 0.0 2.2 2 0 0 2 2 2 0 RACo linker region DUF1265 PF06887.14 ELR11358.1 - 0.11 12.4 0.5 0.32 11.0 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1265) RACo_linker PF17650.1 ELR11359.1 - 0.011 15.6 0.0 0.68 9.8 0.0 2.4 2 0 0 2 2 2 0 RACo linker region RabGGT_insert PF07711.11 ELR11361.1 - 0.01 16.3 0.0 0.02 15.4 0.0 1.4 1 0 0 1 1 1 1 Rab geranylgeranyl transferase alpha-subunit, insert domain NT-C2 PF10358.9 ELR11363.1 - 0.0014 18.4 0.7 0.0034 17.1 0.3 1.9 2 0 0 2 2 2 1 N-terminal C2 in EEIG1 and EHBP1 proteins DUF4407 PF14362.6 ELR11363.1 - 0.0076 15.6 28.2 0.042 13.2 15.0 2.3 1 1 1 2 2 2 2 Domain of unknown function (DUF4407) ATG16 PF08614.11 ELR11363.1 - 0.008 16.4 29.7 0.11 12.8 2.4 2.4 2 0 0 2 2 2 2 Autophagy protein 16 (ATG16) Rnk_N PF14760.6 ELR11363.1 - 0.015 15.8 8.0 1.6 9.2 0.1 3.6 3 0 0 3 3 3 0 Rnk N-terminus Herpes_UL6 PF01763.16 ELR11363.1 - 0.018 13.6 0.8 0.018 13.6 0.8 2.2 2 0 0 2 2 2 0 Herpesvirus UL6 like TMF_DNA_bd PF12329.8 ELR11363.1 - 0.023 14.7 6.6 0.023 14.7 6.6 5.4 5 1 1 6 6 5 0 TATA element modulatory factor 1 DNA binding Bap31_Bap29_C PF18035.1 ELR11363.1 - 0.026 14.5 0.6 0.026 14.5 0.6 4.8 4 0 0 4 4 4 0 Bap31/Bap29 cytoplasmic coiled-coil domain DUF5339 PF17274.2 ELR11363.1 - 0.066 14.1 1.6 0.066 14.1 1.6 4.1 4 1 1 5 5 3 0 Family of unknown function (DUF5339) Spc29 PF17082.5 ELR11363.1 - 0.39 10.5 20.5 0.1 12.4 1.1 2.3 1 1 1 2 2 2 0 Spindle Pole Component 29 Bcr-Abl_Oligo PF09036.10 ELR11363.1 - 0.61 10.1 16.8 0.62 10.1 0.7 3.9 2 1 1 3 3 3 0 Bcr-Abl oncoprotein oligomerisation domain DivIC PF04977.15 ELR11363.1 - 0.82 9.5 32.5 0.046 13.5 2.6 3.8 4 0 0 4 4 4 0 Septum formation initiator EzrA PF06160.12 ELR11363.1 - 1.2 7.2 20.4 0.091 10.9 14.7 1.9 2 0 0 2 2 2 0 Septation ring formation regulator, EzrA Tropomyosin_1 PF12718.7 ELR11363.1 - 2.7 8.1 40.4 0.34 11.1 8.5 2.8 1 1 1 2 2 2 0 Tropomyosin like ING PF12998.7 ELR11363.1 - 3.6 8.2 11.3 5.8 7.6 0.5 2.6 2 0 0 2 2 2 0 Inhibitor of growth proteins N-terminal histone-binding GAS PF13851.6 ELR11363.1 - 4.4 6.6 42.8 1.9 7.8 6.8 3.8 2 1 2 4 4 4 0 Growth-arrest specific micro-tubule binding Fez1 PF06818.15 ELR11363.1 - 7.2 7.0 33.7 0.8 10.1 5.1 2.5 1 1 0 2 2 2 0 Fez1 FlxA PF14282.6 ELR11363.1 - 7.7 6.6 32.5 0.1 12.6 4.7 4.5 2 1 2 4 4 4 0 FlxA-like protein HMMR_N PF15905.5 ELR11363.1 - 8.5 5.7 37.5 0.27 10.6 19.6 2.5 1 1 1 2 2 2 0 Hyaluronan mediated motility receptor N-terminal Cu-oxidase_3 PF07732.15 ELR11364.1 - 0.047 13.7 0.0 5 7.2 0.0 2.1 2 0 0 2 2 2 0 Multicopper oxidase Cu-oxidase_2 PF07731.14 ELR11364.1 - 0.14 11.9 0.1 0.28 10.9 0.1 1.5 1 0 0 1 1 1 0 Multicopper oxidase PAS PF00989.25 ELR11365.1 - 0.00072 19.5 0.0 0.0082 16.1 0.0 2.3 3 0 0 3 3 3 1 PAS fold PAS_3 PF08447.12 ELR11365.1 - 0.001 19.3 0.0 0.15 12.4 0.0 2.5 2 0 0 2 2 2 1 PAS fold PAS_8 PF13188.7 ELR11365.1 - 0.0014 18.6 0.0 0.0038 17.2 0.0 1.8 1 0 0 1 1 1 1 PAS domain PAS_9 PF13426.7 ELR11365.1 - 0.0051 17.0 0.0 0.029 14.6 0.0 2.1 1 1 1 2 2 2 1 PAS domain PAS_12 PF18095.1 ELR11365.1 - 0.12 12.0 0.0 0.18 11.4 0.0 1.2 1 0 0 1 1 1 0 UPF0242 C-terminal PAS-like domain Frizzled PF01534.17 ELR11366.1 - 6.2e-11 41.9 19.2 1e-10 41.2 19.2 1.4 1 0 0 1 1 1 1 Frizzled/Smoothened family membrane region Fz PF01392.22 ELR11366.1 - 0.15 12.7 1.6 0.25 12.0 0.1 2.2 2 0 0 2 2 2 0 Fz domain TPR_2 PF07719.17 ELR11367.1 - 2.9 8.2 6.1 98 3.5 0.1 3.9 2 1 3 6 6 6 0 Tetratricopeptide repeat Peptidase_S64 PF08192.11 ELR11368.1 - 0.096 11.2 4.6 2.1 6.8 5.4 2.0 2 0 0 2 2 2 0 Peptidase family S64 DUF913 PF06025.12 ELR11368.1 - 1.3 7.9 5.3 2.4 7.1 5.3 1.4 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Serinc PF03348.15 ELR11368.1 - 2.1 7.2 4.3 3 6.7 4.3 1.2 1 0 0 1 1 1 0 Serine incorporator (Serinc) Sigma70_ner PF04546.13 ELR11368.1 - 3 7.7 16.8 0.19 11.6 11.3 1.9 2 0 0 2 2 2 0 Sigma-70, non-essential region PHD PF00628.29 ELR11370.1 - 3.1e-23 81.4 22.3 4.4e-13 48.9 6.2 2.8 2 0 0 2 2 2 2 PHD-finger zf-HC5HC2H PF13771.6 ELR11370.1 - 0.00011 22.4 4.4 0.044 14.0 0.6 3.0 2 0 0 2 2 2 2 PHD-like zinc-binding domain zf-HC5HC2H_2 PF13832.6 ELR11370.1 - 0.16 12.2 4.4 2.9 8.1 0.4 2.7 2 0 0 2 2 2 0 PHD-zinc-finger like domain LSM PF01423.22 ELR11371.1 - 9.4e-16 57.3 0.2 1.2e-15 56.9 0.2 1.2 1 0 0 1 1 1 1 LSM domain Tail_tube PF10618.9 ELR11371.1 - 0.037 13.9 0.0 0.088 12.7 0.0 1.6 1 1 1 2 2 2 0 Phage tail tube protein SM-ATX PF14438.6 ELR11371.1 - 0.046 13.9 0.0 0.064 13.4 0.0 1.3 1 0 0 1 1 1 0 Ataxin 2 SM domain BET PF17035.5 ELR11372.1 - 1.3e-25 89.3 0.1 3.2e-25 88.1 0.1 1.7 1 0 0 1 1 1 1 Bromodomain extra-terminal - transcription regulation Bromodomain PF00439.25 ELR11372.1 - 2.4e-20 72.4 0.0 1.5e-19 69.8 0.0 2.1 2 0 0 2 2 2 1 Bromodomain BUD22 PF09073.10 ELR11372.1 - 0.069 12.5 42.5 0.025 13.9 17.0 2.4 2 0 0 2 2 2 0 BUD22 RR_TM4-6 PF06459.12 ELR11372.1 - 1.1 9.0 30.8 0.22 11.3 13.1 2.7 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 CNDH2_C PF16858.5 ELR11372.1 - 1.8 8.4 27.2 2.7 7.8 7.7 2.4 2 0 0 2 2 2 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term SDA1 PF05285.12 ELR11372.1 - 1.9 7.8 40.7 0.51 9.7 14.4 2.5 2 0 0 2 2 2 0 SDA1 PLAC8 PF04749.17 ELR11373.1 - 6e-17 62.5 16.6 7.1e-17 62.2 16.6 1.1 1 0 0 1 1 1 1 PLAC8 family Thioredoxin PF00085.20 ELR11373.1 - 2.5 8.1 6.2 5.2 7.1 0.2 2.2 2 0 0 2 2 2 0 Thioredoxin SRI PF08236.11 ELR11374.1 - 1.2e-18 67.1 8.5 1.2e-18 67.1 8.5 1.7 2 0 0 2 2 2 1 SRI (Set2 Rpb1 interacting) domain DUF383 PF04063.14 ELR11374.1 - 0.049 13.3 0.1 0.06 13.0 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF383) DUF4441 PF14536.6 ELR11374.1 - 0.053 13.7 0.1 0.079 13.2 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4441) MDM10 PF12519.8 ELR11374.1 - 2.2 7.0 6.1 2.7 6.8 6.1 1.0 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 Amino_oxidase PF01593.24 ELR11375.1 - 1.7e-99 334.2 0.1 1.1e-76 259.0 0.0 2.4 2 0 0 2 2 2 2 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 ELR11375.1 - 2.3e-13 50.2 0.5 5.7e-13 48.9 0.5 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain SWIRM PF04433.17 ELR11375.1 - 6.2e-10 39.3 0.0 1.4e-09 38.2 0.0 1.5 1 0 0 1 1 1 1 SWIRM domain Pyr_redox_2 PF07992.14 ELR11375.1 - 5e-08 32.5 0.1 3.9e-06 26.3 0.0 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 ELR11375.1 - 4.7e-07 30.3 0.1 3.6e-05 24.2 0.2 2.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 ELR11375.1 - 2e-06 26.8 0.8 3.7e-05 22.6 0.2 2.6 3 0 0 3 3 3 1 HI0933-like protein DAO PF01266.24 ELR11375.1 - 2.8e-06 27.2 0.0 0.0002 21.1 0.0 3.0 3 0 0 3 3 3 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 ELR11375.1 - 5.3e-05 22.5 1.8 0.00015 21.0 1.5 1.8 2 0 0 2 2 2 1 FAD binding domain AlaDh_PNT_C PF01262.21 ELR11375.1 - 7.3e-05 22.2 0.1 0.00013 21.4 0.1 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain Pyr_redox_3 PF13738.6 ELR11375.1 - 0.00032 20.1 0.0 0.018 14.3 0.0 2.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 ELR11375.1 - 0.00032 20.0 0.2 0.00057 19.2 0.2 1.3 1 0 0 1 1 1 1 Thi4 family Glu_dehyd_C PF16912.5 ELR11375.1 - 0.0019 17.7 0.0 0.0034 16.9 0.0 1.3 1 0 0 1 1 1 1 Glucose dehydrogenase C-terminus NAD_binding_9 PF13454.6 ELR11375.1 - 0.0054 16.7 0.1 3.9 7.5 0.1 2.9 2 0 0 2 2 2 1 FAD-NAD(P)-binding GIDA PF01134.22 ELR11375.1 - 0.013 14.6 0.7 0.022 13.9 0.7 1.3 1 0 0 1 1 1 0 Glucose inhibited division protein A FAD_binding_3 PF01494.19 ELR11375.1 - 0.021 14.1 0.4 0.021 14.1 0.4 2.5 3 0 0 3 3 3 0 FAD binding domain XdhC_C PF13478.6 ELR11375.1 - 0.037 14.5 0.0 0.22 12.1 0.0 2.3 2 0 0 2 2 2 0 XdhC Rossmann domain FAD_oxidored PF12831.7 ELR11375.1 - 0.06 12.7 6.9 0.13 11.5 6.8 1.8 1 1 0 1 1 1 0 FAD dependent oxidoreductase Shikimate_DH PF01488.20 ELR11375.1 - 0.095 12.8 0.0 0.18 11.8 0.0 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase YjeF_N PF03853.15 ELR11375.1 - 0.12 12.3 0.1 0.27 11.1 0.1 1.5 1 0 0 1 1 1 0 YjeF-related protein N-terminus LRR_8 PF13855.6 ELR11376.1 - 0.00035 20.3 2.6 0.04 13.7 0.4 2.7 1 1 1 2 2 2 2 Leucine rich repeat LRR_4 PF12799.7 ELR11376.1 - 0.00036 20.9 3.6 2.7 8.5 0.0 3.5 1 1 3 4 4 4 4 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 ELR11376.1 - 0.37 10.9 3.7 28 5.1 0.1 4.4 5 0 0 5 5 5 0 Leucine Rich repeat Ribosomal_L28 PF00830.19 ELR11378.1 - 0.051 13.8 0.0 0.085 13.1 0.0 1.3 1 0 0 1 1 1 0 Ribosomal L28 family EF-hand_7 PF13499.6 ELR11379.1 - 2e-20 73.0 2.4 1.1e-11 44.9 0.2 2.5 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 ELR11379.1 - 2.9e-20 70.4 3.4 4e-06 26.3 0.1 4.2 4 0 0 4 4 4 4 EF-hand domain EF-hand_1 PF00036.32 ELR11379.1 - 4.2e-20 69.7 9.4 3.4e-08 32.5 0.2 4.2 4 0 0 4 4 4 4 EF hand EF-hand_5 PF13202.6 ELR11379.1 - 3e-14 51.7 5.2 1.9e-06 27.1 0.3 4.2 4 0 0 4 4 4 3 EF hand EF-hand_8 PF13833.6 ELR11379.1 - 2.7e-10 39.9 7.3 1.8e-07 30.9 1.2 3.6 1 1 2 3 3 3 2 EF-hand domain pair EF-hand_9 PF14658.6 ELR11379.1 - 4e-07 30.3 0.2 0.00029 21.1 0.1 3.6 3 1 0 3 3 3 1 EF-hand domain SPARC_Ca_bdg PF10591.9 ELR11379.1 - 5.7e-05 23.4 0.0 0.97 9.8 0.0 2.9 3 0 0 3 3 3 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_14 PF17959.1 ELR11379.1 - 0.0036 17.6 0.3 0.16 12.3 0.1 2.8 2 1 1 3 3 3 1 EF-hand domain p25-alpha PF05517.12 ELR11379.1 - 0.0068 16.6 3.2 0.017 15.3 1.3 2.1 1 1 1 2 2 2 1 p25-alpha EF-hand_2 PF09068.11 ELR11379.1 - 0.0086 16.2 0.1 0.027 14.6 0.0 1.8 2 1 0 2 2 2 1 EF hand EF-hand_4 PF12763.7 ELR11379.1 - 0.025 14.5 0.2 0.055 13.4 0.1 1.5 1 1 0 1 1 1 0 Cytoskeletal-regulatory complex EF hand NLRC4_HD2 PF17776.1 ELR11379.1 - 0.053 14.1 0.0 0.099 13.2 0.0 1.5 1 0 0 1 1 1 0 NLRC4 helical domain HD2 EF-hand_3 PF09069.11 ELR11379.1 - 0.11 13.0 0.1 0.54 10.7 0.0 1.9 2 1 0 2 2 2 0 EF-hand Ank_2 PF12796.7 ELR11380.1 - 0.0012 19.4 0.0 0.0015 19.1 0.0 1.3 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 ELR11380.1 - 0.0026 18.0 0.0 0.0047 17.2 0.0 1.5 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_4 PF13637.6 ELR11380.1 - 0.031 14.9 0.0 0.12 13.0 0.0 1.9 1 1 0 1 1 1 0 Ankyrin repeats (many copies) Ank PF00023.30 ELR11380.1 - 0.073 13.6 0.0 1.6 9.3 0.0 2.3 2 0 0 2 2 2 0 Ankyrin repeat CENP-M PF11111.8 ELR11381.1 - 1.2e-10 40.9 0.0 1.2e-10 40.8 0.0 1.0 1 0 0 1 1 1 1 Centromere protein M (CENP-M) DUF5050 PF16472.5 ELR11381.1 - 0.036 13.3 0.0 0.04 13.1 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF5050) Ras PF00071.22 ELR11381.1 - 0.13 11.9 0.0 0.14 11.8 0.0 1.1 1 0 0 1 1 1 0 Ras family SANT_DAMP1_like PF16282.5 ELR11382.1 - 4.5e-09 36.4 0.1 7.7e-09 35.6 0.1 1.3 1 0 0 1 1 1 1 SANT/Myb-like domain of DAMP1 zf-C2H2 PF00096.26 ELR11382.1 - 0.054 14.0 0.6 0.12 12.9 0.1 1.9 2 0 0 2 2 2 0 Zinc finger, C2H2 type Myb_DNA-binding PF00249.31 ELR11382.1 - 0.067 13.4 0.0 0.13 12.5 0.0 1.4 1 0 0 1 1 1 0 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 ELR11382.1 - 0.16 12.3 0.1 0.43 10.9 0.1 1.7 1 0 0 1 1 1 0 Myb-like DNA-binding domain UPF0020 PF01170.18 ELR11383.1 - 4.3e-29 101.6 0.1 5.5e-26 91.5 0.1 3.1 1 1 0 1 1 1 1 Putative RNA methylase family UPF0020 THUMP PF02926.17 ELR11383.1 - 2.1e-05 24.7 0.0 3.3e-05 24.0 0.0 1.3 1 0 0 1 1 1 1 THUMP domain AviRa PF11599.8 ELR11383.1 - 0.0018 17.8 0.0 1.9 7.9 0.0 2.7 2 1 1 3 3 3 2 RRNA methyltransferase AviRa SDA1 PF05285.12 ELR11384.1 - 0.054 12.9 62.6 0.077 12.4 62.6 1.3 1 0 0 1 1 1 0 SDA1 Utp14 PF04615.13 ELR11384.1 - 0.57 8.7 54.7 0.73 8.3 54.7 1.1 1 0 0 1 1 1 0 Utp14 protein GREB1 PF15782.5 ELR11384.1 - 4.9 4.1 22.4 5.7 3.9 22.4 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Cofilin_ADF PF00241.20 ELR11385.1 - 2.3e-24 85.5 0.0 5e-11 42.5 0.0 2.4 2 0 0 2 2 2 2 Cofilin/tropomyosin-type actin-binding protein C2 PF00168.30 ELR11385.1 - 3.7e-23 81.8 0.1 2.1e-22 79.3 0.1 2.3 3 0 0 3 3 3 1 C2 domain SET PF00856.28 ELR11386.1 - 5.7e-11 43.1 0.0 8.4e-11 42.5 0.0 1.4 1 1 0 1 1 1 1 SET domain zf-MYND PF01753.18 ELR11386.1 - 0.00073 19.6 14.5 0.00073 19.6 14.5 2.7 2 1 0 2 2 2 1 MYND finger Sds3 PF08598.11 ELR11387.1 - 3.7e-05 23.8 4.9 0.0042 17.1 6.2 2.1 2 0 0 2 2 2 2 Sds3-like Mito_carr PF00153.27 ELR11388.1 - 1.1e-54 182.3 0.5 1.2e-20 73.2 0.1 3.9 4 0 0 4 4 4 3 Mitochondrial carrier protein AMPK1_CBM PF16561.5 ELR11389.1 - 7.5e-35 119.0 0.6 1.1e-34 118.4 0.6 1.2 1 0 0 1 1 1 1 Glycogen recognition site of AMP-activated protein kinase CBM_48 PF02922.18 ELR11389.1 - 0.11 12.9 0.1 0.18 12.2 0.1 1.4 1 0 0 1 1 1 0 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) Nucleo_P87 PF07267.11 ELR11390.1 - 4.8 5.9 6.0 6.3 5.5 6.0 1.0 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 DSBA PF01323.20 ELR11391.1 - 4.4e-33 114.7 0.0 5.1e-33 114.5 0.0 1.0 1 0 0 1 1 1 1 DSBA-like thioredoxin domain SinI PF08671.10 ELR11391.1 - 0.032 14.0 0.3 0.084 12.7 0.0 1.9 2 0 0 2 2 2 0 Anti-repressor SinI Acetyltransf_1 PF00583.25 ELR11391.1 - 0.063 13.5 0.0 0.093 13.0 0.0 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family Pkinase_Tyr PF07714.17 ELR11393.1 - 7.8e-47 159.7 0.0 1.1e-46 159.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ELR11393.1 - 4.7e-43 147.5 0.0 6.8e-43 146.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Haspin_kinase PF12330.8 ELR11393.1 - 0.0026 16.8 0.0 0.021 13.8 0.0 2.1 2 0 0 2 2 2 1 Haspin like kinase domain FTA2 PF13095.6 ELR11393.1 - 0.0061 16.2 0.0 0.014 15.1 0.0 1.6 1 0 0 1 1 1 1 Kinetochore Sim4 complex subunit FTA2 ABC1 PF03109.16 ELR11393.1 - 0.021 15.0 0.0 0.2 11.8 0.0 2.2 2 0 0 2 2 2 0 ABC1 family APH PF01636.23 ELR11393.1 - 0.1 12.5 0.0 0.17 11.7 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Med18 PF09637.10 ELR11394.1 - 1.2e-12 48.2 0.0 1.8e-10 41.1 0.0 2.1 2 0 0 2 2 2 2 Med18 protein V-ATPase_H_C PF11698.8 ELR11396.1 - 1.6e-37 128.2 0.7 1.4e-36 125.1 0.1 2.2 2 0 0 2 2 2 1 V-ATPase subunit H V-ATPase_H_N PF03224.14 ELR11396.1 - 1.7e-16 60.5 0.4 1.2e-15 57.7 0.4 1.9 2 0 0 2 2 2 1 V-ATPase subunit H Cyt-b5 PF00173.28 ELR11396.1 - 0.011 15.9 0.0 0.02 15.0 0.0 1.4 1 0 0 1 1 1 0 Cytochrome b5-like Heme/Steroid binding domain DUF2258 PF10015.9 ELR11396.1 - 0.1 12.8 0.5 2.5 8.3 0.5 2.5 1 1 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2258) RNase_H2_suC PF08615.11 ELR11397.1 - 6.3e-17 62.1 0.2 4.7e-14 52.7 0.2 2.2 1 1 0 1 1 1 1 Ribonuclease H2 non-catalytic subunit (Ylr154p-like) AlbA_2 PF04326.14 ELR11398.1 - 0.0044 17.3 0.0 0.097 13.0 0.0 2.2 2 0 0 2 2 2 1 Putative DNA-binding domain SIMPL PF04402.14 ELR11399.1 - 1.3e-22 81.2 11.3 1.8e-22 80.8 11.3 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF541) DUF1995 PF09353.10 ELR11399.1 - 0.15 12.1 1.2 1.7 8.6 0.3 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF1995) MMR_HSR1_C PF08438.10 ELR11400.1 - 4.6e-33 114.1 0.3 1.6e-32 112.4 0.0 2.1 3 0 0 3 3 3 1 GTPase of unknown function C-terminal MMR_HSR1 PF01926.23 ELR11400.1 - 9.1e-21 74.1 0.0 8e-20 71.0 0.0 2.4 2 1 1 3 3 3 1 50S ribosome-binding GTPase FeoB_N PF02421.18 ELR11400.1 - 5.4e-06 26.0 0.0 1.9e-05 24.3 0.0 1.9 2 0 0 2 2 2 1 Ferrous iron transport protein B Dynamin_N PF00350.23 ELR11400.1 - 0.0046 17.0 2.8 0.084 12.9 0.0 3.0 3 1 0 3 3 3 1 Dynamin family F-box-like PF12937.7 ELR11401.1 - 3.3e-06 26.9 0.4 6.1e-06 26.0 0.4 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ELR11401.1 - 0.00029 20.6 0.1 0.0006 19.6 0.1 1.6 1 0 0 1 1 1 1 F-box domain F-box_4 PF15966.5 ELR11401.1 - 0.0095 15.8 0.1 0.021 14.7 0.1 1.5 1 0 0 1 1 1 1 F-box TOM20_plant PF06552.12 ELR11402.1 - 0.0011 18.8 0.1 0.013 15.2 0.1 2.1 1 1 0 1 1 1 1 Plant specific mitochondrial import receptor subunit TOM20 TPR_17 PF13431.6 ELR11402.1 - 0.079 13.4 0.4 16 6.1 0.1 3.3 2 0 0 2 2 2 0 Tetratricopeptide repeat Homeodomain PF00046.29 ELR11403.1 - 2.7e-20 72.0 3.2 5.9e-20 70.9 3.2 1.6 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 ELR11403.1 - 0.00018 21.3 0.1 0.00036 20.4 0.1 1.5 1 0 0 1 1 1 1 Homeobox KN domain Homez PF11569.8 ELR11403.1 - 0.08 12.4 0.0 0.19 11.2 0.0 1.6 1 0 0 1 1 1 0 Homeodomain leucine-zipper encoding, Homez MitMem_reg PF13012.6 ELR11404.1 - 5.2e-36 123.5 1.0 8.3e-36 122.8 1.0 1.3 1 0 0 1 1 1 1 Maintenance of mitochondrial structure and function JAB PF01398.21 ELR11404.1 - 5.5e-33 113.4 0.0 1.4e-32 112.1 0.0 1.7 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease zf-primase PF09329.11 ELR11405.1 - 3.5e-12 45.9 0.3 6.7e-12 45.0 0.3 1.5 1 0 0 1 1 1 1 Primase zinc finger Cofilin_ADF PF00241.20 ELR11406.1 - 1.5e-32 112.0 0.0 1.4e-17 63.7 0.0 2.2 2 0 0 2 2 2 2 Cofilin/tropomyosin-type actin-binding protein MoaF_C PF17409.2 ELR11407.1 - 0.031 14.0 0.0 0.064 12.9 0.0 1.4 1 0 0 1 1 1 0 MoaF C-terminal domain Metallophos PF00149.28 ELR11408.1 - 3.4e-24 86.5 2.1 6.5e-23 82.3 2.1 2.1 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase TetR_C_11 PF16859.5 ELR11409.1 - 0.57 10.5 3.6 15 6.0 0.1 4.0 4 0 0 4 4 4 0 Tetracyclin repressor-like, C-terminal domain Nup188 PF10487.9 ELR11410.1 - 1.3e-40 139.2 5.7 3.6e-21 74.9 0.4 4.1 2 1 2 4 4 4 4 Nucleoporin subcomplex protein binding to Pom34 Nup192 PF11894.8 ELR11410.1 - 2.4e-15 54.9 8.6 7.7e-06 23.4 1.1 3.1 3 0 0 3 3 3 3 Nuclear pore complex scaffold, nucleoporins 186/192/205 TerB PF05099.13 ELR11410.1 - 0.00068 19.6 1.3 0.0016 18.4 1.3 1.6 1 0 0 1 1 1 1 Tellurite resistance protein TerB HD_assoc PF13286.6 ELR11410.1 - 0.22 12.1 0.8 42 4.8 0.0 3.8 4 0 0 4 4 4 0 Phosphohydrolase-associated domain Bystin PF05291.11 ELR11412.1 - 8.6e-132 438.8 1.3 1e-131 438.6 1.3 1.0 1 0 0 1 1 1 1 Bystin Pkinase PF00069.25 ELR11413.1 - 1.4e-21 77.1 0.0 1.9e-21 76.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR11413.1 - 1.1e-09 38.0 0.0 1.5e-09 37.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 ELR11413.1 - 0.014 15.3 0.1 0.09 12.7 0.1 1.9 1 1 1 2 2 2 0 Phosphotransferase enzyme family Kdo PF06293.14 ELR11413.1 - 0.038 13.3 0.1 0.056 12.8 0.1 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family HLH PF00010.26 ELR11415.1 - 2.9e-09 36.8 0.2 4.8e-09 36.0 0.2 1.4 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Nucleo_P87 PF07267.11 ELR11415.1 - 0.0072 15.3 3.0 0.01 14.7 3.0 1.2 1 0 0 1 1 1 1 Nucleopolyhedrovirus capsid protein P87 CDC45 PF02724.14 ELR11415.1 - 0.023 13.0 12.3 0.034 12.4 12.3 1.2 1 0 0 1 1 1 0 CDC45-like protein Shugoshin_N PF07558.11 ELR11415.1 - 0.15 11.9 2.7 0.3 11.0 2.7 1.3 1 0 0 1 1 1 0 Shugoshin N-terminal coiled-coil region Nop14 PF04147.12 ELR11415.1 - 0.33 9.1 11.5 0.5 8.5 11.5 1.1 1 0 0 1 1 1 0 Nop14-like family Vfa1 PF08432.10 ELR11415.1 - 0.87 9.9 4.3 1.8 8.8 4.3 1.5 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Sporozoite_P67 PF05642.11 ELR11415.1 - 7.2 4.6 20.2 0.099 10.7 8.2 2.1 2 0 0 2 2 2 0 Sporozoite P67 surface antigen NOA36 PF06524.12 ELR11415.1 - 8.2 5.6 12.4 13 4.9 12.4 1.2 1 0 0 1 1 1 0 NOA36 protein HlyIII PF03006.20 ELR11416.1 - 3.5e-18 66.1 22.0 4.4e-18 65.8 22.0 1.1 1 0 0 1 1 1 1 Haemolysin-III related DUF962 PF06127.11 ELR11416.1 - 1.1 9.4 8.6 7.6 6.7 8.4 2.4 1 1 0 1 1 1 0 Protein of unknown function (DUF962) RFX_DNA_binding PF02257.15 ELR11417.1 - 4.2e-17 62.5 0.1 8.7e-17 61.5 0.1 1.5 1 0 0 1 1 1 1 RFX DNA-binding domain FA_desaturase PF00487.24 ELR11418.1 - 3e-18 66.6 43.0 2.2e-16 60.5 21.1 4.6 4 1 1 5 5 5 3 Fatty acid desaturase Cyt-b5 PF00173.28 ELR11418.1 - 4.3e-13 49.2 0.0 8.4e-13 48.3 0.0 1.5 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Methyltransf_PK PF05891.12 ELR11419.1 - 5.4e-76 254.9 0.0 2.4e-63 213.6 0.0 2.1 2 0 0 2 2 2 2 AdoMet dependent proline di-methyltransferase Methyltransf_12 PF08242.12 ELR11419.1 - 6e-10 39.8 0.0 1.1e-09 38.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ELR11419.1 - 7.1e-09 36.3 0.0 1.3e-08 35.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ELR11419.1 - 1.1e-06 29.2 0.0 1.9e-06 28.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_2 PF00891.18 ELR11419.1 - 0.00083 18.7 0.0 0.0012 18.2 0.0 1.3 1 0 0 1 1 1 1 O-methyltransferase domain RrnaAD PF00398.20 ELR11419.1 - 0.035 13.2 0.0 0.05 12.7 0.0 1.1 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase Methyltransf_31 PF13847.6 ELR11419.1 - 0.068 13.0 0.0 0.14 12.0 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain Succ_CoA_lig PF13607.6 ELR11419.1 - 0.11 12.3 0.0 0.24 11.2 0.0 1.5 1 0 0 1 1 1 0 Succinyl-CoA ligase like flavodoxin domain Spermine_synth PF01564.17 ELR11419.1 - 0.18 11.2 0.0 0.27 10.6 0.0 1.3 1 0 0 1 1 1 0 Spermine/spermidine synthase domain SSP160 PF06933.11 ELR11419.1 - 0.34 9.0 8.2 0.45 8.7 8.2 1.0 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 Utp14 PF04615.13 ELR11420.1 - 1.2e-148 497.0 81.1 5.2e-90 303.1 56.9 2.2 1 1 1 2 2 2 2 Utp14 protein HVSL PF09749.9 ELR11422.1 - 4.9e-40 137.5 0.0 6.9e-40 137.0 0.0 1.2 1 0 0 1 1 1 1 Uncharacterised conserved protein 2_5_RNA_ligase2 PF13563.6 ELR11422.1 - 0.00086 19.2 0.0 0.016 15.1 0.0 2.5 1 1 1 2 2 2 1 2'-5' RNA ligase superfamily ShK PF01549.24 ELR11423.1 - 3.5e-05 24.3 7.8 3.5e-05 24.3 7.8 2.8 4 1 0 4 4 4 1 ShK domain-like EB PF01683.18 ELR11423.1 - 0.25 11.7 22.6 3.3 8.1 5.4 2.8 1 1 1 2 2 2 0 EB module RACo_linker PF17650.1 ELR11425.1 - 0.0033 17.2 1.6 0.0033 17.2 1.6 1.7 2 0 0 2 2 2 1 RACo linker region GPI2 PF06432.11 ELR11427.1 - 3.6e-78 262.8 14.7 4.2e-78 262.6 14.7 1.0 1 0 0 1 1 1 1 Phosphatidylinositol N-acetylglucosaminyltransferase DUF563 PF04577.14 ELR11428.1 - 1.5e-17 64.5 0.1 2.7e-17 63.6 0.1 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF563) Pkinase_Tyr PF07714.17 ELR11429.1 - 8e-53 179.4 0.0 5.1e-51 173.4 0.0 2.4 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ELR11429.1 - 7.8e-44 150.0 0.0 3.4e-42 144.7 0.0 2.2 1 1 0 1 1 1 1 Protein kinase domain Ank_2 PF12796.7 ELR11429.1 - 7.9e-15 55.2 0.2 0.00012 22.6 0.0 4.5 2 1 2 4 4 4 4 Ankyrin repeats (3 copies) Ank PF00023.30 ELR11429.1 - 3.8e-13 49.2 4.4 3e-05 24.3 0.3 5.0 4 1 0 4 4 4 4 Ankyrin repeat Ank_5 PF13857.6 ELR11429.1 - 4.6e-13 49.1 0.6 0.0066 16.8 0.0 4.9 5 0 0 5 5 5 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 ELR11429.1 - 1.1e-12 46.9 4.4 8.8e-05 22.6 0.2 5.5 6 0 0 6 6 5 2 Ankyrin repeat Ank_4 PF13637.6 ELR11429.1 - 3.5e-11 43.4 0.1 0.0045 17.5 0.0 4.1 3 1 0 3 3 3 2 Ankyrin repeats (many copies) Haspin_kinase PF12330.8 ELR11429.1 - 0.0045 16.0 1.0 0.0088 15.0 0.0 1.8 2 0 0 2 2 2 1 Haspin like kinase domain APH PF01636.23 ELR11429.1 - 0.093 12.6 0.1 0.093 12.6 0.1 2.4 2 0 0 2 2 2 0 Phosphotransferase enzyme family PKS_DE PF18369.1 ELR11429.1 - 0.14 12.8 0.1 0.35 11.5 0.1 1.7 1 0 0 1 1 1 0 Polyketide synthase dimerisation element domain Pkinase_fungal PF17667.1 ELR11429.1 - 0.18 10.5 0.0 0.18 10.5 0.0 1.6 2 0 0 2 2 2 0 Fungal protein kinase Condensin2nSMC PF12422.8 ELR11430.1 - 3.8e-55 186.2 0.1 3.6e-54 183.0 0.0 2.8 3 0 0 3 3 3 1 Condensin II non structural maintenance of chromosomes subunit HEAT PF02985.22 ELR11430.1 - 1.6e-06 27.9 5.5 0.078 13.3 0.1 5.5 5 0 0 5 5 5 1 HEAT repeat HEAT_2 PF13646.6 ELR11430.1 - 6e-05 23.4 0.6 0.37 11.2 0.0 4.4 2 1 1 3 3 3 2 HEAT repeats Adaptin_N PF01602.20 ELR11430.1 - 0.00036 19.2 0.3 0.00088 18.0 0.3 1.6 1 0 0 1 1 1 1 Adaptin N terminal region DUF913 PF06025.12 ELR11430.1 - 0.014 14.4 7.4 0.045 12.7 2.0 2.5 3 0 0 3 3 3 0 Domain of Unknown Function (DUF913) AT_hook PF02178.19 ELR11430.1 - 0.02 14.7 1.5 0.068 13.1 1.5 2.0 1 0 0 1 1 1 0 AT hook motif NPR3 PF03666.13 ELR11430.1 - 0.071 11.9 5.5 0.35 9.6 0.4 2.4 2 0 0 2 2 2 0 Nitrogen Permease regulator of amino acid transport activity 3 CENP-L PF13092.6 ELR11430.1 - 0.14 12.4 0.6 2 8.6 0.0 2.9 3 0 0 3 3 3 0 Kinetochore complex Sim4 subunit Fta1 BUD22 PF09073.10 ELR11430.1 - 0.26 10.6 36.2 1.3 8.3 15.4 2.7 2 1 0 2 2 2 0 BUD22 DUF4746 PF15928.5 ELR11430.1 - 0.3 10.5 16.7 3.8 6.8 12.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4746) Zip PF02535.22 ELR11430.1 - 0.97 8.6 5.8 1.2 8.3 2.8 2.2 2 0 0 2 2 2 0 ZIP Zinc transporter eIF-3c_N PF05470.12 ELR11430.1 - 2.2 6.5 11.2 0.07 11.4 2.8 2.1 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit 8 N-terminus Rrn6 PF10214.9 ELR11430.1 - 2.5 6.5 8.1 2.8 6.3 1.3 2.1 2 0 0 2 2 2 0 RNA polymerase I-specific transcription-initiation factor DUF2201_N PF13203.6 ELR11430.1 - 2.9 7.4 13.5 0.94 9.0 0.4 2.7 3 0 0 3 3 3 0 Putative metallopeptidase domain Rsm22 PF09243.10 ELR11435.1 - 0.11 11.8 0.0 0.12 11.6 0.0 1.1 1 0 0 1 1 1 0 Mitochondrial small ribosomal subunit Rsm22 Terminase_6 PF03237.15 ELR11437.1 - 0.071 12.8 0.0 0.11 12.1 0.0 1.3 1 0 0 1 1 1 0 Terminase-like family GvpG PF05120.12 ELR11441.1 - 0.028 14.4 0.0 0.069 13.2 0.0 1.6 1 0 0 1 1 1 0 Gas vesicle protein G Oxidored_FMN PF00724.20 ELR11442.1 - 1.8e-76 257.7 0.0 2.1e-76 257.4 0.0 1.0 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family Dus PF01207.17 ELR11442.1 - 0.0008 18.6 0.2 0.0091 15.1 0.0 2.2 2 0 0 2 2 2 1 Dihydrouridine synthase (Dus) 14-3-3 PF00244.20 ELR11443.1 - 2.3e-68 230.0 2.6 2.1e-67 226.9 2.6 1.9 1 1 0 1 1 1 1 14-3-3 protein DUF2148 PF09918.9 ELR11443.1 - 0.16 12.0 0.2 0.33 11.0 0.2 1.5 1 0 0 1 1 1 0 Uncharacterized protein containing a ferredoxin domain (DUF2148) DHR10 PF18595.1 ELR11443.1 - 0.2 11.7 0.2 0.2 11.7 0.2 3.3 4 0 0 4 4 4 0 Designed helical repeat protein 10 domain TetR_C_14 PF17754.1 ELR11443.1 - 5.4 7.0 7.7 26 4.8 1.1 2.9 3 0 0 3 3 3 0 MftR C-terminal domain TPR_14 PF13428.6 ELR11443.1 - 6 8.0 8.9 35 5.6 0.3 3.5 4 0 0 4 4 4 0 Tetratricopeptide repeat Snf7 PF03357.21 ELR11444.1 - 5.7e-40 136.7 26.0 5.7e-40 136.7 26.0 1.6 2 0 0 2 2 2 1 Snf7 Ist1 PF03398.14 ELR11444.1 - 0.0005 20.0 10.9 0.00069 19.6 10.9 1.2 1 0 0 1 1 1 1 Regulator of Vps4 activity in the MVB pathway DUF2575 PF10837.8 ELR11444.1 - 0.039 14.3 0.2 0.085 13.2 0.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2575) Bestrophin PF01062.21 ELR11444.1 - 0.13 11.7 2.9 0.16 11.3 2.9 1.2 1 0 0 1 1 1 0 Bestrophin, RFP-TM, chloride channel DUF1002 PF06207.11 ELR11444.1 - 1.2 8.6 7.2 0.28 10.7 3.4 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF1002) Y_phosphatase2 PF03162.13 ELR11445.1 - 1.7e-41 141.6 0.0 2.2e-41 141.2 0.0 1.1 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase3 PF13350.6 ELR11445.1 - 8.5e-08 32.4 0.0 1e-07 32.2 0.0 1.1 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase PF00102.27 ELR11445.1 - 0.03 13.9 0.0 0.046 13.3 0.0 1.3 1 0 0 1 1 1 0 Protein-tyrosine phosphatase Peptidase_M1_N PF17900.1 ELR11446.1 - 5.3e-16 59.3 0.0 7.3e-16 58.9 0.0 1.3 1 0 0 1 1 1 1 Peptidase M1 N-terminal domain Peptidase_M1 PF01433.20 ELR11446.1 - 1.6e-08 34.4 0.0 2.4e-08 33.8 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M1 domain DUF1462 PF07315.11 ELR11446.1 - 0.062 13.6 0.0 0.13 12.5 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1462) Peptidase_M1 PF01433.20 ELR11447.1 - 3.6e-17 62.7 0.0 4.1e-17 62.5 0.0 1.0 1 0 0 1 1 1 1 Peptidase family M1 domain Peptidase_M61 PF05299.12 ELR11447.1 - 0.0028 18.0 0.2 0.21 12.0 0.2 2.1 1 1 0 1 1 1 1 M61 glycyl aminopeptidase DUF3458_C PF17432.2 ELR11448.1 - 1.4e-91 307.2 4.2 1.9e-91 306.8 4.2 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3458_C) ARM repeats DUF3458 PF11940.8 ELR11448.1 - 4.3e-25 88.0 0.2 1.1e-24 86.7 0.2 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF3458) Ig-like fold Peptidase_M1 PF01433.20 ELR11448.1 - 4.4e-06 26.4 0.0 7.6e-06 25.6 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M1 domain DUF3106 PF11304.8 ELR11448.1 - 0.1 13.1 0.8 1.9 9.0 0.0 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF3106) DHHC PF01529.20 ELR11450.1 - 2.5e-30 105.3 15.0 9e-28 97.0 15.0 2.5 1 1 0 1 1 1 1 DHHC palmitoyltransferase DHHC PF01529.20 ELR11452.1 - 2.7e-36 124.6 7.8 4.9e-36 123.8 7.8 1.4 1 0 0 1 1 1 1 DHHC palmitoyltransferase C2 PF00168.30 ELR11453.1 - 1.5e-06 28.4 0.0 3.7e-06 27.2 0.0 1.7 1 0 0 1 1 1 1 C2 domain SAVED PF18145.1 ELR11453.1 - 0.024 14.5 0.2 0.044 13.6 0.2 1.4 1 0 0 1 1 1 0 SMODS-associated and fused to various effectors sensor domain Glyco_hydro_63 PF03200.16 ELR11454.1 - 7.9e-05 21.6 0.0 0.0016 17.3 0.0 2.1 2 0 0 2 2 2 2 Glycosyl hydrolase family 63 C-terminal domain Bac_rhamnosid6H PF17389.2 ELR11454.1 - 0.025 13.8 1.5 0.15 11.3 1.5 2.0 1 1 0 1 1 1 0 Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain Metallophos_2 PF12850.7 ELR11455.1 - 2.2e-09 37.7 0.6 1.7e-08 34.9 0.6 2.1 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Nop14 PF04147.12 ELR11455.1 - 0.8 7.8 4.6 1 7.5 4.6 1.1 1 0 0 1 1 1 0 Nop14-like family EzrA PF06160.12 ELR11456.1 - 0.21 9.7 8.5 0.31 9.1 8.5 1.1 1 0 0 1 1 1 0 Septation ring formation regulator, EzrA TLD PF07534.16 ELR11457.1 - 2.2e-14 53.8 0.0 3.4e-14 53.3 0.0 1.3 1 0 0 1 1 1 1 TLD BLOC1_2 PF10046.9 ELR11457.1 - 0.024 14.9 2.6 0.53 10.6 0.7 2.3 2 0 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 PGAP1 PF07819.13 ELR11457.1 - 0.094 12.4 0.1 0.18 11.5 0.1 1.4 1 0 0 1 1 1 0 PGAP1-like protein DUF4954 PF16314.5 ELR11460.1 - 0.12 10.4 0.5 0.15 10.2 0.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4954) Rsm22 PF09243.10 ELR11461.1 - 0.12 11.7 0.0 0.14 11.4 0.0 1.1 1 0 0 1 1 1 0 Mitochondrial small ribosomal subunit Rsm22 COesterase PF00135.28 ELR11462.1 - 1.3e-112 377.3 0.0 1.7e-112 377.0 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 ELR11462.1 - 8.9e-10 38.8 0.9 0.0012 18.8 0.1 2.3 2 0 0 2 2 2 2 alpha/beta hydrolase fold Pkinase_Tyr PF07714.17 ELR11463.1 - 1.4e-56 191.7 0.0 2e-56 191.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ELR11463.1 - 3.5e-49 167.5 0.0 5.3e-49 166.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain PBP_like_2 PF12849.7 ELR11463.1 - 5.2e-21 75.6 3.4 8e-11 42.1 0.0 3.1 3 0 0 3 3 3 2 PBP superfamily domain EGF_2 PF07974.13 ELR11463.1 - 7.6e-06 26.2 12.7 1.6e-05 25.2 12.7 1.6 1 0 0 1 1 1 1 EGF-like domain Kinase-like PF14531.6 ELR11463.1 - 0.03 13.7 0.0 0.06 12.6 0.0 1.4 1 0 0 1 1 1 0 Kinase-like FTA2 PF13095.6 ELR11463.1 - 0.068 12.8 0.0 3.9 7.0 0.0 2.2 1 1 1 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 SIT PF15330.6 ELR11463.1 - 0.071 13.6 0.4 0.2 12.1 0.4 1.8 1 0 0 1 1 1 0 SHP2-interacting transmembrane adaptor protein, SIT EGF_Tenascin PF18720.1 ELR11463.1 - 0.15 12.1 1.9 0.39 10.8 1.9 1.7 1 0 0 1 1 1 0 Tenascin EGF domain hEGF PF12661.7 ELR11463.1 - 0.3 11.8 10.2 0.06 14.0 6.6 1.8 2 0 0 2 2 1 0 Human growth factor-like EGF EGF PF00008.27 ELR11463.1 - 0.54 10.6 7.3 0.97 9.8 7.3 1.4 1 0 0 1 1 1 0 EGF-like domain I-EGF_1 PF18372.1 ELR11463.1 - 0.64 10.2 4.5 1.3 9.2 4.5 1.5 1 0 0 1 1 1 0 Integrin beta epidermal growth factor like domain 1 Laminin_EGF PF00053.24 ELR11463.1 - 1 9.5 8.4 2.2 8.5 8.4 1.5 1 0 0 1 1 1 0 Laminin EGF domain DIMCO_N PF16844.5 ELR11466.1 - 0.01 16.2 1.5 0.095 13.0 0.4 2.3 2 1 1 3 3 3 1 Dinitrogenase iron-molybdenum cofactor, N-terminal CLU PF13236.6 ELR11467.1 - 6.3e-64 215.8 0.0 1.7e-63 214.4 0.0 1.7 1 0 0 1 1 1 1 Clustered mitochondria TPR_17 PF13431.6 ELR11469.1 - 2.7e-14 52.4 0.1 0.0041 17.4 0.0 4.5 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_11 PF13414.6 ELR11469.1 - 7.2e-14 51.2 4.0 2.2e-06 27.2 0.3 4.3 3 1 1 4 4 4 3 TPR repeat TPR_2 PF07719.17 ELR11469.1 - 4.9e-09 35.6 3.2 0.0013 18.7 0.0 5.0 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_14 PF13428.6 ELR11469.1 - 1.1e-07 32.1 1.6 0.0014 19.3 0.1 4.5 4 1 1 5 5 5 1 Tetratricopeptide repeat TPR_16 PF13432.6 ELR11469.1 - 1.2e-07 32.2 3.4 3.3e-05 24.4 0.1 3.9 2 2 2 4 4 4 2 Tetratricopeptide repeat TPR_1 PF00515.28 ELR11469.1 - 2.5e-05 23.9 1.7 0.53 10.2 0.0 4.7 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_19 PF14559.6 ELR11469.1 - 0.00039 20.9 5.8 0.031 14.8 0.3 3.8 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_8 PF13181.6 ELR11469.1 - 0.0011 19.0 0.2 35 5.0 0.0 5.3 6 0 0 6 6 6 0 Tetratricopeptide repeat TOM20_plant PF06552.12 ELR11469.1 - 0.002 17.9 0.1 0.12 12.1 0.1 2.7 1 1 0 2 2 2 1 Plant specific mitochondrial import receptor subunit TOM20 TPR_21 PF09976.9 ELR11469.1 - 0.0038 17.0 0.0 0.0095 15.7 0.0 1.7 1 0 0 1 1 1 1 Tetratricopeptide repeat-like domain TPR_20 PF14561.6 ELR11469.1 - 0.013 15.8 0.2 4 7.8 0.4 3.5 3 1 1 4 4 4 0 Tetratricopeptide repeat iPGM_N PF06415.13 ELR11469.1 - 0.049 13.1 0.2 0.084 12.3 0.2 1.3 1 0 0 1 1 1 0 BPG-independent PGAM N-terminus (iPGM_N) TPR_7 PF13176.6 ELR11469.1 - 0.055 13.5 1.1 1.2 9.3 0.0 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_12 PF13424.6 ELR11469.1 - 0.17 12.2 2.1 1.4 9.3 0.1 3.0 1 1 3 4 4 4 0 Tetratricopeptide repeat LRR_6 PF13516.6 ELR11470.1 - 0.0018 18.2 0.0 6.6 7.1 0.0 3.8 3 0 0 3 3 3 3 Leucine Rich repeat Clusterin PF01093.17 ELR11472.1 - 0.049 12.7 0.0 0.064 12.3 0.0 1.1 1 0 0 1 1 1 0 Clusterin CPSF100_C PF13299.6 ELR11473.1 - 0.053 13.7 0.6 4.5 7.4 0.0 2.1 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal LRR_8 PF13855.6 ELR11474.1 - 1.2e-26 92.2 5.1 5.4e-08 32.5 0.0 4.4 3 1 1 4 4 4 4 Leucine rich repeat LRR_4 PF12799.7 ELR11474.1 - 5.4e-24 83.9 6.0 3.3e-06 27.3 0.0 5.7 4 1 1 5 5 5 5 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 ELR11474.1 - 1e-08 34.9 0.3 0.1 12.1 0.0 3.3 1 1 2 3 3 3 3 Leucine-rich repeat PH PF00169.29 ELR11474.1 - 1.9e-08 34.7 0.0 4.4e-08 33.6 0.0 1.6 1 0 0 1 1 1 1 PH domain LRR_1 PF00560.33 ELR11474.1 - 0.00011 22.3 11.1 1.9 9.3 0.1 7.2 7 0 0 7 7 7 1 Leucine Rich Repeat RsmF_methylt_CI PF17126.5 ELR11474.1 - 0.23 11.5 2.0 11 6.2 0.1 3.5 3 0 0 3 3 3 0 RsmF rRNA methyltransferase first C-terminal domain LRR_6 PF13516.6 ELR11474.1 - 0.77 10.0 7.9 1.5 9.0 0.3 4.8 6 0 0 6 6 6 0 Leucine Rich repeat adh_short PF00106.25 ELR11475.1 - 1.2e-33 116.2 0.1 1.9e-33 115.6 0.1 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ELR11475.1 - 2.1e-26 92.9 0.0 6e-26 91.4 0.0 1.6 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ELR11475.1 - 1.1e-09 38.5 0.2 1.5e-09 38.0 0.2 1.2 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.6 ELR11475.1 - 0.0007 19.5 0.4 0.0011 18.9 0.4 1.4 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 ELR11475.1 - 0.0033 16.9 0.6 0.0068 15.9 0.6 1.8 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 ELR11475.1 - 0.017 14.5 0.0 0.028 13.8 0.0 1.3 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase Pkinase_Tyr PF07714.17 ELR11476.1 - 3.4e-94 314.9 0.0 6.9e-59 199.2 0.0 3.5 2 1 1 3 3 3 3 Protein tyrosine kinase Pkinase PF00069.25 ELR11476.1 - 1.2e-86 290.4 0.0 4.5e-50 170.5 0.0 3.2 2 1 1 3 3 3 3 Protein kinase domain PBP_like_2 PF12849.7 ELR11476.1 - 2.4e-32 112.7 13.9 6.2e-21 75.3 6.6 2.4 2 0 0 2 2 2 2 PBP superfamily domain Guanylate_cyc PF00211.20 ELR11476.1 - 4.2e-08 33.0 0.0 7.8e-08 32.1 0.0 1.4 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain Haspin_kinase PF12330.8 ELR11476.1 - 9.7e-07 28.0 0.2 0.041 12.8 0.0 3.1 3 0 0 3 3 3 2 Haspin like kinase domain APH PF01636.23 ELR11476.1 - 2e-06 28.0 0.2 0.0013 18.7 0.0 2.6 2 0 0 2 2 2 2 Phosphotransferase enzyme family EGF_2 PF07974.13 ELR11476.1 - 0.00048 20.4 9.5 0.00097 19.5 9.5 1.5 1 0 0 1 1 1 1 EGF-like domain Kinase-like PF14531.6 ELR11476.1 - 0.0008 18.8 0.0 0.043 13.1 0.0 2.4 2 0 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 ELR11476.1 - 0.0058 15.5 0.0 0.84 8.3 0.0 2.2 2 0 0 2 2 2 2 Fungal protein kinase FTA2 PF13095.6 ELR11476.1 - 0.023 14.3 0.0 1.6 8.3 0.0 3.1 2 1 1 3 3 3 0 Kinetochore Sim4 complex subunit FTA2 TMEM154 PF15102.6 ELR11476.1 - 0.068 13.1 0.1 0.19 11.6 0.1 1.7 1 0 0 1 1 1 0 TMEM154 protein family RIO1 PF01163.22 ELR11476.1 - 0.17 11.5 0.2 3.4 7.2 0.1 2.3 2 0 0 2 2 2 0 RIO1 family EGF PF00008.27 ELR11476.1 - 0.41 11.0 7.1 0.66 10.3 4.4 2.4 2 0 0 2 2 2 0 EGF-like domain EGF_Tenascin PF18720.1 ELR11476.1 - 1.6 8.9 4.4 3.8 7.7 4.4 1.7 1 0 0 1 1 1 0 Tenascin EGF domain hEGF PF12661.7 ELR11476.1 - 2.4 8.9 6.1 7.7 7.3 6.1 2.0 1 0 0 1 1 1 0 Human growth factor-like EGF Amino_oxidase PF01593.24 ELR11477.1 - 3.7e-54 184.7 0.0 9.5e-53 180.1 0.0 2.0 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 ELR11477.1 - 1.5e-10 41.1 0.7 3.1e-10 40.1 0.7 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.6 ELR11477.1 - 1.3e-09 37.8 0.0 3.8e-05 23.1 0.2 2.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 ELR11477.1 - 0.0016 17.6 0.0 0.0022 17.1 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 ELR11477.1 - 0.0088 15.3 0.9 0.043 13.0 0.2 2.2 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 ELR11477.1 - 0.012 15.2 0.8 0.022 14.4 0.8 1.4 1 0 0 1 1 1 0 FAD dependent oxidoreductase FAD_oxidored PF12831.7 ELR11477.1 - 0.022 14.1 0.0 0.028 13.8 0.0 1.2 1 0 0 1 1 1 0 FAD dependent oxidoreductase Thi4 PF01946.17 ELR11477.1 - 0.037 13.2 0.1 0.064 12.5 0.1 1.3 1 0 0 1 1 1 0 Thi4 family HI0933_like PF03486.14 ELR11477.1 - 0.077 11.7 1.2 0.88 8.2 0.6 2.1 2 0 0 2 2 2 0 HI0933-like protein FAD_binding_3 PF01494.19 ELR11477.1 - 0.098 11.9 0.2 0.15 11.3 0.2 1.2 1 0 0 1 1 1 0 FAD binding domain Pyr_redox PF00070.27 ELR11477.1 - 0.25 11.9 0.8 1.4 9.5 0.5 2.2 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Branch PF02485.21 ELR11482.1 - 7.6e-28 97.7 0.0 1.5e-27 96.7 0.0 1.4 1 1 0 1 1 1 1 Core-2/I-Branching enzyme Presenilin PF01080.17 ELR11484.1 - 0.99 8.1 6.9 0.19 10.5 3.4 1.6 2 0 0 2 2 2 0 Presenilin C2 PF00168.30 ELR11485.1 - 1.5e-05 25.2 0.0 1.8e-05 24.9 0.0 1.1 1 0 0 1 1 1 1 C2 domain YkuI_C PF10388.9 ELR11485.1 - 0.18 11.6 0.1 0.24 11.2 0.1 1.1 1 0 0 1 1 1 0 EAL-domain associated signalling protein domain LIM PF00412.22 ELR11486.1 - 1.1e-15 57.6 20.5 7.7e-09 35.7 7.1 2.6 2 1 0 2 2 2 2 LIM domain zinc_ribbon_4 PF13717.6 ELR11486.1 - 0.18 11.8 0.0 0.18 11.8 0.0 4.8 5 1 0 5 5 5 0 zinc-ribbon domain Plectin PF00681.20 ELR11486.1 - 0.19 11.6 0.0 0.33 10.9 0.0 1.3 1 0 0 1 1 1 0 Plectin repeat zf-SNAP50_C PF12251.8 ELR11486.1 - 3 7.5 15.1 0.31 10.7 2.5 2.7 1 1 1 2 2 2 0 snRNA-activating protein of 50kDa MW C terminal RPE65 PF03055.15 ELR11487.1 - 2.3e-43 149.1 0.0 2.5e-43 148.9 0.0 1.0 1 0 0 1 1 1 1 Retinal pigment epithelial membrane protein Epimerase PF01370.21 ELR11488.1 - 6.9e-18 65.0 0.0 9.5e-18 64.5 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 ELR11488.1 - 3.3e-12 46.2 0.0 5e-12 45.6 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein GDP_Man_Dehyd PF16363.5 ELR11488.1 - 7.4e-11 42.0 0.0 1.1e-10 41.5 0.0 1.2 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase NAD_binding_4 PF07993.12 ELR11488.1 - 5.2e-10 38.9 0.0 6e-07 28.9 0.0 2.1 1 1 0 2 2 2 2 Male sterility protein RmlD_sub_bind PF04321.17 ELR11488.1 - 6.1e-09 35.4 0.0 1.2e-08 34.4 0.0 1.4 1 1 0 1 1 1 1 RmlD substrate binding domain 3Beta_HSD PF01073.19 ELR11488.1 - 1.3e-08 34.2 0.0 1.7e-08 33.8 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.6 ELR11488.1 - 8.3e-07 29.1 0.0 1.3e-06 28.4 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding Sacchrp_dh_NADP PF03435.18 ELR11488.1 - 0.011 16.0 0.0 0.018 15.3 0.0 1.4 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain DapB_N PF01113.20 ELR11488.1 - 0.064 13.4 0.0 0.15 12.2 0.0 1.6 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus DUF4509 PF14970.6 ELR11489.1 - 0.066 13.1 0.6 0.081 12.8 0.6 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4509) RNA_pol_Rpc4 PF05132.14 ELR11489.1 - 0.47 10.9 8.9 0.54 10.7 8.9 1.1 1 0 0 1 1 1 0 RNA polymerase III RPC4 SR-25 PF10500.9 ELR11489.1 - 0.66 9.5 16.5 0.68 9.5 16.5 1.0 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein AP3D1 PF06375.11 ELR11489.1 - 0.68 10.2 16.3 0.78 10.0 16.3 1.1 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 Vfa1 PF08432.10 ELR11489.1 - 1.7 8.9 14.2 1.8 8.9 14.2 1.0 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Peptidase_S49_N PF08496.10 ELR11489.1 - 1.7 8.7 11.2 2.3 8.3 11.2 1.3 1 0 0 1 1 1 0 Peptidase family S49 N-terminal Rtf2 PF04641.12 ELR11489.1 - 1.8 7.9 12.6 1.9 7.8 12.6 1.1 1 0 0 1 1 1 0 Rtf2 RING-finger RPN2_C PF18004.1 ELR11489.1 - 4.1 7.3 14.4 4.3 7.2 14.4 1.1 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain Presenilin PF01080.17 ELR11489.1 - 4.6 5.9 4.6 4.5 5.9 4.6 1.0 1 0 0 1 1 1 0 Presenilin Connexin PF00029.19 ELR11489.1 - 6.6 6.4 6.7 6.5 6.4 6.7 1.0 1 0 0 1 1 1 0 Connexin Sec62 PF03839.16 ELR11489.1 - 6.8 6.1 8.1 7.1 6.1 8.1 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 Zip PF02535.22 ELR11489.1 - 7.3 5.7 4.6 7.4 5.7 4.6 1.0 1 0 0 1 1 1 0 ZIP Zinc transporter DUF3341 PF11821.8 ELR11490.1 - 0.95 9.1 4.1 1.7 8.3 4.1 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3341) Sterol-sensing PF12349.8 ELR11491.1 - 5.4e-23 81.5 5.9 4e-12 46.2 0.1 2.3 2 0 0 2 2 2 2 Sterol-sensing domain of SREBP cleavage-activation Patched PF02460.18 ELR11491.1 - 5.5e-23 81.0 0.0 7.2e-23 80.6 0.0 1.1 1 0 0 1 1 1 1 Patched family MMPL PF03176.15 ELR11491.1 - 0.064 12.2 6.1 0.43 9.4 0.0 2.2 2 0 0 2 2 2 0 MMPL family DUF2070 PF09843.9 ELR11491.1 - 1.4 7.1 9.1 2.4 6.3 8.6 1.3 1 1 0 1 1 1 0 Predicted membrane protein (DUF2070) Apt1 PF10351.9 ELR11491.1 - 2.2 7.1 4.8 0.6 8.9 0.4 2.1 3 0 0 3 3 3 0 Golgi-body localisation protein domain SAPS PF04499.15 ELR11491.1 - 2.5 6.8 4.2 0.3 9.8 0.1 1.5 2 0 0 2 2 2 0 SIT4 phosphatase-associated protein Merozoite_SPAM PF07133.11 ELR11491.1 - 7.1 6.6 21.7 13 5.7 21.7 1.4 1 0 0 1 1 1 0 Merozoite surface protein (SPAM) HAD_SAK_1 PF10307.9 ELR11492.1 - 1.9e-33 116.0 0.0 2.7e-33 115.5 0.0 1.2 1 0 0 1 1 1 1 HAD domain family 1 in Swiss Army Knife RNA repair proteins HAD PF12710.7 ELR11492.1 - 0.015 15.7 0.1 4.4 7.7 0.1 2.6 2 1 0 3 3 3 0 haloacid dehalogenase-like hydrolase FIIND PF13553.6 ELR11492.1 - 0.08 12.3 0.1 0.13 11.6 0.1 1.3 1 0 0 1 1 1 0 Function to find GPI2 PF06432.11 ELR11495.1 - 1.9e-78 263.8 14.8 2.2e-78 263.6 14.8 1.0 1 0 0 1 1 1 1 Phosphatidylinositol N-acetylglucosaminyltransferase PhnH PF05845.12 ELR11497.1 - 0.086 12.6 0.0 0.1 12.3 0.0 1.1 1 0 0 1 1 1 0 Bacterial phosphonate metabolism protein (PhnH) UBA PF00627.31 ELR11499.1 - 9.9e-18 63.7 4.0 5e-09 35.9 0.0 4.0 4 0 0 4 4 4 2 UBA/TS-N domain ubiquitin PF00240.23 ELR11499.1 - 6.1e-06 25.9 0.0 1.8e-05 24.4 0.0 1.8 1 0 0 1 1 1 1 Ubiquitin family CUE PF02845.16 ELR11499.1 - 0.00012 21.7 0.1 0.0029 17.3 0.0 2.6 2 0 0 2 2 2 1 CUE domain UBA_4 PF14555.6 ELR11499.1 - 0.00044 20.0 1.0 0.15 11.9 0.0 4.4 5 0 0 5 5 5 1 UBA-like domain Ubiquitin_5 PF18037.1 ELR11499.1 - 0.00075 19.8 1.4 0.011 16.1 0.7 2.8 2 0 0 2 2 2 1 Ubiquitin-like domain Rad60-SLD_2 PF13881.6 ELR11499.1 - 0.0017 18.5 0.4 0.0075 16.4 0.4 2.1 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 ELR11499.1 - 0.019 15.4 0.1 0.11 13.0 0.0 2.3 1 1 0 1 1 1 0 Ubiquitin-like domain TPR_2 PF07719.17 ELR11499.1 - 0.11 12.7 4.8 14 6.1 0.0 4.1 4 0 0 4 4 4 0 Tetratricopeptide repeat DUF2407 PF10302.9 ELR11499.1 - 1.6 9.4 5.5 1.4 9.5 0.4 3.0 3 1 0 3 3 3 0 DUF2407 ubiquitin-like domain DUF3824 PF12868.7 ELR11499.1 - 6.7 7.4 10.2 12 6.5 2.3 2.5 2 0 0 2 2 2 0 Domain of unknwon function (DUF3824) Histidinol_dh PF00815.20 ELR11500.1 - 6.7e-129 430.5 1.5 1.5e-128 429.3 1.5 1.6 1 0 0 1 1 1 1 Histidinol dehydrogenase His_biosynth PF00977.21 ELR11500.1 - 5e-124 412.2 8.1 2.9e-80 269.0 1.7 2.5 2 0 0 2 2 2 2 Histidine biosynthesis protein PRA-CH PF01502.18 ELR11500.1 - 9.5e-25 86.2 0.1 1.8e-24 85.3 0.1 1.5 1 0 0 1 1 1 1 Phosphoribosyl-AMP cyclohydrolase HisG PF01634.18 ELR11500.1 - 3.7e-23 82.3 0.0 7.6e-23 81.2 0.0 1.5 1 0 0 1 1 1 1 ATP phosphoribosyltransferase HisG_C PF08029.11 ELR11500.1 - 2.6e-17 62.7 0.1 1.2e-16 60.7 0.0 2.3 2 0 0 2 2 1 1 HisG, C-terminal domain DHO_dh PF01180.21 ELR11500.1 - 4.8e-14 52.3 0.3 0.00032 20.0 0.2 3.3 3 0 0 3 3 3 3 Dihydroorotate dehydrogenase PRA-PH PF01503.17 ELR11500.1 - 1.4e-12 47.8 0.2 4.8e-12 46.2 0.2 2.0 1 0 0 1 1 1 1 Phosphoribosyl-ATP pyrophosphohydrolase GATase PF00117.28 ELR11500.1 - 2e-10 40.8 0.0 5.1e-10 39.4 0.0 1.6 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Dus PF01207.17 ELR11500.1 - 2.3e-08 33.5 0.3 0.00036 19.7 0.0 3.2 2 1 1 3 3 3 2 Dihydrouridine synthase (Dus) NMO PF03060.15 ELR11500.1 - 2.8e-07 30.3 11.8 4.2e-06 26.4 1.5 3.8 3 1 0 3 3 3 2 Nitronate monooxygenase ThiG PF05690.14 ELR11500.1 - 2e-06 27.3 7.2 0.0066 15.8 0.2 3.6 3 0 0 3 3 3 2 Thiazole biosynthesis protein ThiG TMP-TENI PF02581.17 ELR11500.1 - 1e-05 25.0 2.5 0.033 13.5 0.1 3.4 4 0 0 4 4 4 2 Thiamine monophosphate synthase PcrB PF01884.17 ELR11500.1 - 1.6e-05 24.5 0.1 0.13 11.7 0.0 2.6 2 0 0 2 2 2 2 PcrB family Trp_syntA PF00290.20 ELR11500.1 - 7.1e-05 21.8 3.4 0.018 13.9 0.1 3.2 3 0 0 3 3 3 2 Tryptophan synthase alpha chain IMPDH PF00478.25 ELR11500.1 - 0.00014 21.0 14.2 0.0012 17.9 0.4 3.9 5 0 0 5 5 5 2 IMP dehydrogenase / GMP reductase domain G3P_antiterm PF04309.12 ELR11500.1 - 0.00028 20.3 3.6 0.34 10.3 0.1 3.1 3 0 0 3 3 3 2 Glycerol-3-phosphate responsive antiterminator SNO PF01174.19 ELR11500.1 - 0.0035 17.2 0.0 3 7.6 0.0 2.7 2 0 0 2 2 2 2 SNO glutamine amidotransferase family MazG PF03819.17 ELR11500.1 - 0.011 15.9 0.2 0.027 14.7 0.2 1.7 1 0 0 1 1 1 0 MazG nucleotide pyrophosphohydrolase domain GATase_3 PF07685.14 ELR11500.1 - 0.029 14.0 0.0 0.17 11.4 0.0 2.2 2 0 0 2 2 2 0 CobB/CobQ-like glutamine amidotransferase domain BtpA PF03437.15 ELR11500.1 - 0.071 12.5 4.2 0.11 11.9 2.0 2.5 2 1 0 2 2 2 0 BtpA family MazG-like PF12643.7 ELR11500.1 - 0.18 12.1 0.9 1 9.6 0.1 2.5 2 0 0 2 2 2 0 MazG-like family Ras PF00071.22 ELR11501.1 - 1.2e-58 197.3 0.0 1.4e-58 197.1 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR11501.1 - 8.8e-32 109.8 0.0 1.4e-31 109.2 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR11501.1 - 9.9e-17 60.9 0.0 1.3e-16 60.6 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 ELR11501.1 - 2.1e-06 27.4 0.1 4.5e-06 26.3 0.0 1.6 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 ELR11501.1 - 0.00012 22.2 0.0 0.00021 21.4 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 ELR11501.1 - 0.00018 21.5 0.1 0.16 11.8 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase Gtr1_RagA PF04670.12 ELR11501.1 - 0.0016 17.9 0.0 0.0021 17.5 0.0 1.3 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region AAA_24 PF13479.6 ELR11501.1 - 0.023 14.4 0.7 0.19 11.4 0.7 2.2 1 1 0 1 1 1 0 AAA domain FeoB_N PF02421.18 ELR11501.1 - 0.083 12.4 0.0 0.42 10.1 0.0 1.9 1 1 0 1 1 1 0 Ferrous iron transport protein B AAA_16 PF13191.6 ELR11501.1 - 0.13 12.6 0.1 0.41 11.0 0.1 1.8 1 1 0 1 1 1 0 AAA ATPase domain AAA PF00004.29 ELR11502.1 - 4.7e-48 162.9 0.0 5.5e-40 136.9 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 ELR11502.1 - 5.2e-11 42.2 2.7 5.1e-07 29.4 0.6 2.6 2 0 0 2 2 2 2 AAA+ lid domain AAA_16 PF13191.6 ELR11502.1 - 7.1e-08 33.0 4.4 0.00075 19.9 0.1 3.8 2 2 0 2 2 2 2 AAA ATPase domain AAA_5 PF07728.14 ELR11502.1 - 2.1e-07 31.0 0.1 0.046 13.7 0.0 3.4 3 1 0 3 3 3 2 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 ELR11502.1 - 8.8e-07 29.3 0.1 0.048 13.9 0.0 3.5 2 1 1 3 3 3 2 AAA domain TIP49 PF06068.13 ELR11502.1 - 2.5e-06 26.9 0.6 0.00029 20.1 0.0 2.2 2 0 0 2 2 2 1 TIP49 P-loop domain RuvB_N PF05496.12 ELR11502.1 - 0.00015 21.6 0.0 0.028 14.2 0.0 2.7 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain RNA_helicase PF00910.22 ELR11502.1 - 0.00016 22.0 0.0 0.022 15.2 0.0 2.8 3 0 0 3 3 3 1 RNA helicase Sigma54_activat PF00158.26 ELR11502.1 - 0.00027 20.7 0.1 0.46 10.2 0.0 2.7 3 0 0 3 3 3 2 Sigma-54 interaction domain AAA_7 PF12775.7 ELR11502.1 - 0.00074 19.1 0.0 0.22 11.0 0.0 2.3 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_2 PF07724.14 ELR11502.1 - 0.0012 19.0 0.0 0.003 17.7 0.0 1.7 2 0 0 2 2 1 1 AAA domain (Cdc48 subfamily) Mg_chelatase PF01078.21 ELR11502.1 - 0.0012 18.2 0.9 0.33 10.3 0.1 2.4 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI TsaE PF02367.17 ELR11502.1 - 0.0013 18.7 0.4 0.44 10.5 0.0 2.3 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_33 PF13671.6 ELR11502.1 - 0.0019 18.3 0.0 1.2 9.3 0.0 2.9 3 0 0 3 3 2 1 AAA domain IstB_IS21 PF01695.17 ELR11502.1 - 0.0027 17.5 0.1 0.2 11.4 0.0 2.6 3 0 0 3 3 3 1 IstB-like ATP binding protein AAA_14 PF13173.6 ELR11502.1 - 0.0028 17.7 0.0 0.063 13.3 0.0 2.2 2 0 0 2 2 2 1 AAA domain NACHT PF05729.12 ELR11502.1 - 0.0037 17.2 0.3 2.8 7.8 0.0 2.7 2 0 0 2 2 2 1 NACHT domain AAA_18 PF13238.6 ELR11502.1 - 0.0042 17.6 0.0 1 9.9 0.0 2.5 2 0 0 2 2 2 1 AAA domain DUF815 PF05673.13 ELR11502.1 - 0.0057 15.9 0.0 2.4 7.2 0.0 2.3 2 0 0 2 2 2 2 Protein of unknown function (DUF815) Hpr_kinase_C PF07475.12 ELR11502.1 - 0.009 15.6 0.4 2.4 7.7 0.4 2.3 2 0 0 2 2 2 1 HPr Serine kinase C-terminal domain Sigma54_activ_2 PF14532.6 ELR11502.1 - 0.016 15.3 0.0 0.22 11.6 0.0 2.4 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_3 PF07726.11 ELR11502.1 - 0.056 13.3 0.0 14 5.6 0.0 2.8 3 0 0 3 3 2 0 ATPase family associated with various cellular activities (AAA) AAA_24 PF13479.6 ELR11502.1 - 0.065 13.0 0.0 0.38 10.5 0.0 2.1 2 0 0 2 2 2 0 AAA domain ATPase PF06745.13 ELR11502.1 - 0.078 12.3 0.4 1.6 8.0 0.0 2.4 2 0 0 2 2 2 0 KaiC Rad17 PF03215.15 ELR11502.1 - 0.13 12.1 0.0 2.2 8.2 0.0 2.2 2 0 0 2 2 2 0 Rad17 P-loop domain IF4E PF01652.18 ELR11503.1 - 1.1e-34 119.5 0.2 8.4e-34 116.7 0.2 1.9 1 1 0 1 1 1 1 Eukaryotic initiation factor 4E Orf78 PF06024.12 ELR11504.1 - 0.0024 18.1 0.0 0.0029 17.9 0.0 1.2 1 0 0 1 1 1 1 Orf78 (ac78) EVI2A PF05399.11 ELR11504.1 - 0.0045 16.6 0.0 0.0047 16.6 0.0 1.1 1 0 0 1 1 1 1 Ectropic viral integration site 2A protein (EVI2A) TRIQK PF15168.6 ELR11504.1 - 0.0085 16.0 6.9 0.27 11.2 6.9 2.1 1 1 0 1 1 1 1 Triple QxxK/R motif-containing protein family TMEM154 PF15102.6 ELR11504.1 - 0.014 15.3 0.0 0.016 15.2 0.0 1.1 1 0 0 1 1 1 0 TMEM154 protein family RIFIN PF02009.16 ELR11504.1 - 0.015 15.2 0.0 0.018 15.0 0.0 1.0 1 0 0 1 1 1 0 Rifin DUF5383 PF17355.2 ELR11504.1 - 0.022 15.1 0.5 0.027 14.8 0.5 1.3 1 1 0 1 1 1 0 Family of unknown function (DUF5383) CbtA PF09490.10 ELR11504.1 - 0.024 14.4 0.0 0.025 14.3 0.0 1.0 1 0 0 1 1 1 0 Probable cobalt transporter subunit (CbtA) VEGFR-2_TMD PF17988.1 ELR11504.1 - 0.028 13.8 2.3 0.037 13.5 2.3 1.2 1 0 0 1 1 1 0 VEGFR-2 Transmembrane domain Amnionless PF14828.6 ELR11504.1 - 0.037 12.8 0.1 0.045 12.6 0.1 1.0 1 0 0 1 1 1 0 Amnionless Pox_EPC_I2-L1 PF12575.8 ELR11504.1 - 0.061 13.5 0.3 0.091 13.0 0.3 1.2 1 0 0 1 1 1 0 Poxvirus entry protein complex L1 and I2 DUF4366 PF14283.6 ELR11504.1 - 0.099 12.7 0.0 0.11 12.5 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4366) DUF5589 PF17672.1 ELR11504.1 - 0.15 12.0 1.5 0.23 11.4 1.2 1.4 1 1 0 1 1 1 0 Family of unknown function (DUF5589) SNARE PF05739.19 ELR11504.1 - 0.24 11.4 1.6 0.41 10.7 0.4 1.9 2 0 0 2 2 2 0 SNARE domain Sigma_reg_N PF13800.6 ELR11504.1 - 3.2 8.1 6.5 33 4.9 5.5 2.1 1 1 1 2 2 2 0 Sigma factor regulator N-terminal DUF1768 PF08719.11 ELR11505.1 - 1.2e-13 51.6 0.0 7.6e-13 49.0 0.0 1.8 1 1 0 1 1 1 1 Domain of unknown function (DUF1768) PARP PF00644.20 ELR11506.1 - 1.4e-74 250.0 0.0 3.8e-74 248.5 0.0 1.8 2 0 0 2 2 2 1 Poly(ADP-ribose) polymerase catalytic domain PARP_reg PF02877.14 ELR11506.1 - 5.8e-41 139.8 2.0 1e-40 139.0 2.0 1.4 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase, regulatory domain WGR PF05406.15 ELR11506.1 - 3.2e-19 68.8 0.4 1e-18 67.2 0.4 2.0 1 0 0 1 1 1 1 WGR domain PADR1 PF08063.12 ELR11506.1 - 5e-17 61.4 1.7 1e-16 60.4 1.7 1.6 1 0 0 1 1 1 1 PADR1 (NUC008) domain zf-PARP PF00645.18 ELR11506.1 - 8.5e-15 55.4 0.7 8.5e-15 55.4 0.7 2.1 2 0 0 2 2 2 1 Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region Carot_N PF09150.10 ELR11506.1 - 0.006 16.5 0.3 0.015 15.1 0.0 1.8 2 0 0 2 2 2 1 Orange carotenoid protein, N-terminal DUF4945 PF16303.5 ELR11506.1 - 0.11 12.5 0.2 0.28 11.1 0.2 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4945) DUF2147 PF09917.9 ELR11506.1 - 0.55 10.9 3.3 0.82 10.4 1.6 2.1 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2147) F-box-like PF12937.7 ELR11507.1 - 4.7e-15 55.2 0.1 9.3e-15 54.3 0.1 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ELR11507.1 - 2.5e-10 40.0 0.1 6.9e-10 38.6 0.0 1.7 2 0 0 2 2 2 1 F-box domain NAD_binding_2 PF03446.15 ELR11509.1 - 2.7e-40 138.1 0.0 4.7e-40 137.3 0.0 1.4 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.6 ELR11509.1 - 2e-16 60.3 0.1 4.1e-16 59.3 0.1 1.5 1 0 0 1 1 1 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase F420_oxidored PF03807.17 ELR11509.1 - 1.3e-05 25.6 0.0 3.8e-05 24.2 0.0 1.8 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent 2-Hacid_dh_C PF02826.19 ELR11509.1 - 0.00032 20.1 0.0 0.00065 19.1 0.0 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 3HCDH_N PF02737.18 ELR11509.1 - 0.042 13.7 0.0 0.065 13.1 0.0 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain UDPG_MGDP_dh PF00984.19 ELR11509.1 - 0.051 13.8 0.0 0.097 12.9 0.0 1.4 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, central domain Ribosomal_L12_N PF16320.5 ELR11509.1 - 0.23 11.2 5.6 0.34 10.7 0.3 3.1 3 0 0 3 3 3 0 Ribosomal protein L7/L12 dimerisation domain Siva PF05458.12 ELR11510.1 - 5.8e-08 32.6 12.1 7.4e-08 32.3 12.1 1.2 1 0 0 1 1 1 1 Cd27 binding protein (Siva) IBR PF01485.21 ELR11510.1 - 1.4 9.2 17.4 0.96 9.7 2.7 2.9 1 1 1 2 2 2 0 IBR domain, a half RING-finger domain SUIM_assoc PF16619.5 ELR11510.1 - 2.6 8.2 11.8 7.5 6.7 11.6 1.9 2 1 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 FYVE PF01363.21 ELR11510.1 - 9.7 6.4 19.5 44 4.3 17.4 2.5 2 1 0 2 2 2 0 FYVE zinc finger zf-4CXXC_R1 PF10497.9 ELR11511.1 - 0.0006 20.0 9.2 0.0014 18.8 9.2 1.6 1 0 0 1 1 1 1 Zinc-finger domain of monoamine-oxidase A repressor R1 BTB PF00651.31 ELR11511.1 - 0.053 13.7 0.0 5 7.4 0.0 2.4 2 0 0 2 2 2 0 BTB/POZ domain WH2 PF02205.20 ELR11512.1 - 8.6e-08 31.8 2.0 0.036 13.9 0.1 3.5 4 0 0 4 4 4 3 WH2 motif YAF2_RYBP PF17219.3 ELR11512.1 - 0.068 12.8 0.4 1.4 8.6 0.1 2.8 3 1 1 4 4 4 0 Yaf2/RYBP C-terminal binding motif Pkinase PF00069.25 ELR11513.1 - 1.2e-62 211.7 0.0 1.6e-62 211.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR11513.1 - 1.5e-32 112.9 0.0 2.5e-32 112.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 ELR11513.1 - 0.016 15.2 1.5 0.94 9.3 1.8 2.3 1 1 1 2 2 2 0 Phosphotransferase enzyme family Kdo PF06293.14 ELR11513.1 - 0.025 13.9 0.0 0.037 13.4 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family ApoC-I PF04691.12 ELR11513.1 - 0.11 12.5 0.0 0.19 11.6 0.0 1.4 1 0 0 1 1 1 0 Apolipoprotein C-I (ApoC-1) RIO1 PF01163.22 ELR11513.1 - 0.14 11.7 0.0 0.26 10.9 0.0 1.4 1 0 0 1 1 1 0 RIO1 family Choline_kinase PF01633.20 ELR11514.1 - 2.9e-34 118.5 0.0 5.8e-34 117.5 0.0 1.5 1 1 0 1 1 1 1 Choline/ethanolamine kinase APH PF01636.23 ELR11514.1 - 1.5e-06 28.4 0.0 4.3e-06 26.8 0.0 1.8 1 1 1 2 2 2 1 Phosphotransferase enzyme family Hist_deacetyl PF00850.19 ELR11515.1 - 1.2e-73 248.3 0.6 2.2e-73 247.4 0.6 1.4 1 0 0 1 1 1 1 Histone deacetylase domain SDA1 PF05285.12 ELR11515.1 - 0.0049 16.3 16.2 0.0049 16.3 16.2 4.2 3 1 1 4 4 4 1 SDA1 YL1 PF05764.13 ELR11515.1 - 0.0053 16.9 22.2 0.0053 16.9 22.2 4.6 3 2 1 4 4 4 1 YL1 nuclear protein DUF642 PF04862.12 ELR11521.1 - 0.13 12.0 0.1 0.21 11.4 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF642) DUF3827 PF12877.7 ELR11522.1 - 0.05 12.0 0.9 0.074 11.4 0.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3827) SP_C-Propep PF08999.10 ELR11522.1 - 0.084 12.7 0.9 0.18 11.6 0.9 1.6 1 0 0 1 1 1 0 Surfactant protein C, N terminal propeptide ECSCR PF15820.5 ELR11522.1 - 0.33 10.8 1.9 1 9.2 1.9 1.8 1 0 0 1 1 1 0 Endothelial cell-specific chemotaxis regulator Rax2 PF12768.7 ELR11522.1 - 0.48 9.8 4.1 0.14 11.6 0.5 1.8 2 0 0 2 2 2 0 Cortical protein marker for cell polarity UDPGP PF01704.18 ELR11523.1 - 1.3e-45 155.8 0.0 1.7e-45 155.4 0.0 1.1 1 0 0 1 1 1 1 UTP--glucose-1-phosphate uridylyltransferase FNIP PF05725.12 ELR11524.1 - 1.5e-05 25.1 4.3 0.14 12.4 0.1 4.2 4 1 0 4 4 4 2 FNIP Repeat F-box PF00646.33 ELR11524.1 - 3.2e-05 23.7 0.0 0.00012 21.8 0.0 2.0 1 0 0 1 1 1 1 F-box domain LRR_4 PF12799.7 ELR11524.1 - 0.00011 22.4 6.8 0.52 10.8 0.1 5.3 4 2 0 4 4 4 2 Leucine Rich repeats (2 copies) F-box-like PF12937.7 ELR11524.1 - 0.00014 21.7 0.3 0.00053 19.8 0.3 2.1 1 0 0 1 1 1 1 F-box-like LRR_8 PF13855.6 ELR11524.1 - 0.00057 19.6 7.2 0.057 13.2 1.0 4.4 3 1 2 5 5 5 3 Leucine rich repeat F-box_4 PF15966.5 ELR11524.1 - 0.026 14.4 0.1 0.1 12.5 0.0 1.9 1 1 1 2 2 2 0 F-box LRR_6 PF13516.6 ELR11524.1 - 0.097 12.8 8.6 25 5.3 0.0 6.0 8 0 0 8 8 8 0 Leucine Rich repeat Methyltransf_7 PF03492.15 ELR11525.1 - 7.4e-28 97.7 0.0 9.7e-28 97.3 0.0 1.1 1 0 0 1 1 1 1 SAM dependent carboxyl methyltransferase VIT PF08487.10 ELR11526.1 - 9.2e-37 125.7 0.8 2.1e-36 124.5 0.8 1.7 1 0 0 1 1 1 1 Vault protein inter-alpha-trypsin domain VWA_3 PF13768.6 ELR11526.1 - 1.2e-30 106.5 0.0 2.1e-30 105.7 0.0 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain VIT_2 PF13757.6 ELR11526.1 - 1.6e-16 60.0 0.0 3.8e-16 58.8 0.0 1.6 1 0 0 1 1 1 1 Vault protein inter-alpha-trypsin domain VWA PF00092.28 ELR11526.1 - 7.5e-12 45.8 0.0 1.2e-11 45.1 0.0 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.6 ELR11526.1 - 5.8e-09 36.6 0.0 1.4e-08 35.4 0.0 1.7 1 0 0 1 1 1 1 von Willebrand factor type A domain DUF588 PF04535.12 ELR11526.1 - 0.14 11.9 4.6 0.43 10.3 4.6 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF588) Ins145_P3_rec PF08709.11 ELR11529.1 - 2.3e-49 167.5 0.0 1.4e-45 155.1 0.0 4.1 3 0 0 3 3 3 2 Inositol 1,4,5-trisphosphate/ryanodine receptor RYDR_ITPR PF01365.21 ELR11529.1 - 2.3e-31 108.8 24.8 2.4e-20 72.8 1.8 3.9 3 0 0 3 3 3 2 RIH domain RIH_assoc PF08454.11 ELR11529.1 - 6.2e-31 106.2 0.2 6.2e-31 106.2 0.2 5.8 5 1 0 5 5 5 1 RyR and IP3R Homology associated MIR PF02815.19 ELR11529.1 - 6.3e-18 65.3 0.0 6.3e-18 65.3 0.0 5.1 5 2 0 5 5 5 1 MIR domain Ion_trans PF00520.31 ELR11529.1 - 8e-14 51.5 8.8 1.9e-13 50.3 8.8 1.6 1 0 0 1 1 1 1 Ion transport protein SPOC PF07744.13 ELR11529.1 - 0.073 13.0 0.6 0.89 9.5 0.0 2.9 3 0 0 3 3 3 0 SPOC domain Baculo_PEP_C PF04513.12 ELR11529.1 - 0.67 10.0 12.3 0.36 10.9 1.3 3.4 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus LRR_4 PF12799.7 ELR11530.1 - 4.9e-06 26.8 6.5 0.18 12.3 0.0 6.5 5 3 1 7 7 7 2 Leucine Rich repeats (2 copies) F-box PF00646.33 ELR11530.1 - 4.3e-05 23.3 0.0 0.00012 21.9 0.0 1.7 1 0 0 1 1 1 1 F-box domain LRR_8 PF13855.6 ELR11530.1 - 0.00016 21.4 3.9 0.27 11.0 0.1 5.8 8 1 0 8 8 8 1 Leucine rich repeat LRR_6 PF13516.6 ELR11530.1 - 0.0012 18.7 15.2 0.056 13.5 0.1 6.6 8 0 0 8 8 8 2 Leucine Rich repeat F-box-like PF12937.7 ELR11530.1 - 0.0086 16.0 0.1 0.021 14.7 0.1 1.7 1 0 0 1 1 1 1 F-box-like LRR_1 PF00560.33 ELR11530.1 - 0.026 15.0 4.6 35 5.5 0.0 5.6 7 1 0 7 7 7 0 Leucine Rich Repeat Abhydro_lipase PF04083.16 ELR11531.1 - 5.3e-13 48.3 0.0 8.9e-13 47.6 0.0 1.4 1 0 0 1 1 1 1 Partial alpha/beta-hydrolase lipase region Abhydrolase_1 PF00561.20 ELR11531.1 - 1.1e-08 35.0 0.4 5.4e-06 26.2 0.4 2.2 1 1 0 2 2 2 2 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 ELR11531.1 - 0.00014 21.2 0.0 0.22 10.8 0.0 2.2 1 1 0 2 2 2 2 Serine aminopeptidase, S33 DLH PF01738.18 ELR11531.1 - 0.0083 15.7 0.0 0.013 15.1 0.0 1.5 1 1 0 1 1 1 1 Dienelactone hydrolase family Corona_M PF01635.18 ELR11531.1 - 0.097 12.0 0.1 0.15 11.3 0.1 1.2 1 0 0 1 1 1 0 Coronavirus M matrix/glycoprotein F-box PF00646.33 ELR11532.1 - 4.3e-05 23.3 0.0 7.8e-05 22.5 0.0 1.4 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 ELR11532.1 - 0.0012 18.7 0.1 0.0021 17.9 0.1 1.4 1 0 0 1 1 1 1 F-box-like Abhydrolase_1 PF00561.20 ELR11533.1 - 0.0042 16.8 0.1 0.019 14.6 0.0 1.8 2 0 0 2 2 2 1 alpha/beta hydrolase fold Methyltransf_16 PF10294.9 ELR11534.1 - 2.9e-24 85.7 0.0 4e-24 85.3 0.0 1.1 1 0 0 1 1 1 1 Lysine methyltransferase Methyltransf_23 PF13489.6 ELR11534.1 - 4.5e-06 26.6 0.0 6e-06 26.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 ELR11534.1 - 0.00056 19.5 0.0 0.00076 19.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_31 PF13847.6 ELR11534.1 - 0.0045 16.8 0.0 0.0065 16.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ELR11534.1 - 0.006 17.3 0.1 0.013 16.1 0.1 1.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 ELR11534.1 - 0.019 15.7 0.0 0.032 15.0 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain PocR PF10114.9 ELR11534.1 - 0.11 12.3 0.0 0.19 11.5 0.0 1.3 1 0 0 1 1 1 0 Sensory domain found in PocR Cons_hypoth95 PF03602.15 ELR11534.1 - 0.11 12.1 0.0 0.15 11.7 0.0 1.2 1 0 0 1 1 1 0 Conserved hypothetical protein 95 Metallophos PF00149.28 ELR11535.1 - 1.9e-13 51.4 0.1 2.7e-13 50.9 0.1 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 ELR11535.1 - 1.8e-08 34.7 0.6 2.1e-07 31.3 0.6 2.2 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Usp PF00582.26 ELR11535.1 - 0.0027 18.2 1.0 0.0057 17.2 0.2 1.8 2 0 0 2 2 2 1 Universal stress protein family APH PF01636.23 ELR11536.1 - 9.8e-27 94.4 0.0 1.6e-26 93.7 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Fructosamin_kin PF03881.14 ELR11536.1 - 0.00024 20.4 0.1 0.068 12.4 0.0 2.7 2 2 0 2 2 2 2 Fructosamine kinase EcKinase PF02958.20 ELR11536.1 - 0.0072 15.7 0.0 0.013 14.8 0.0 1.4 1 0 0 1 1 1 1 Ecdysteroid kinase Choline_kinase PF01633.20 ELR11536.1 - 0.088 12.4 0.0 0.22 11.1 0.0 1.7 1 1 0 1 1 1 0 Choline/ethanolamine kinase DUF1679 PF07914.11 ELR11536.1 - 0.24 10.2 0.0 0.42 9.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1679) Pkinase_Tyr PF07714.17 ELR11537.1 - 3.8e-54 183.7 0.0 5.4e-54 183.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ELR11537.1 - 8.2e-52 176.2 0.0 1.2e-51 175.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Haspin_kinase PF12330.8 ELR11537.1 - 8.7e-05 21.6 0.0 0.00013 21.0 0.0 1.2 1 0 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 ELR11537.1 - 0.00041 19.8 0.0 0.00067 19.1 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 ELR11537.1 - 0.003 16.9 0.0 0.0049 16.2 0.0 1.3 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 ELR11537.1 - 0.0078 16.2 0.0 0.024 14.5 0.0 1.8 1 1 1 2 2 2 1 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 ELR11537.1 - 0.0088 14.9 0.0 0.013 14.3 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase EMP24_GP25L PF01105.24 ELR11538.1 - 4.4e-31 108.2 3.1 5.3e-31 108.0 3.1 1.1 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD PALP PF00291.25 ELR11539.1 - 3.4e-39 135.0 2.6 4.5e-37 128.0 2.6 2.7 1 1 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme ADH_zinc_N PF00107.26 ELR11539.1 - 0.11 12.5 0.0 0.24 11.4 0.0 1.6 1 0 0 1 1 1 0 Zinc-binding dehydrogenase ECH_2 PF16113.5 ELR11541.1 - 3.8e-107 358.7 0.0 4.3e-107 358.5 0.0 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_1 PF00378.20 ELR11541.1 - 1.9e-27 96.2 0.0 3.5e-27 95.3 0.0 1.4 1 1 1 2 2 2 1 Enoyl-CoA hydratase/isomerase Pkinase_Tyr PF07714.17 ELR11542.1 - 2.1e-62 210.7 0.0 2.9e-62 210.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ELR11542.1 - 1.9e-54 184.8 0.0 2.8e-54 184.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain eIF3_subunit PF08597.10 ELR11542.1 - 0.78 9.6 14.5 1.2 9.0 14.5 1.2 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit PPP4R2 PF09184.11 ELR11542.1 - 0.85 9.2 8.0 1.3 8.5 8.0 1.2 1 0 0 1 1 1 0 PPP4R2 WD40 PF00400.32 ELR11544.1 - 6e-59 194.6 11.8 3.2e-12 46.7 0.0 7.0 7 0 0 7 7 7 6 WD domain, G-beta repeat TFIID_NTD2 PF04494.15 ELR11544.1 - 2.7e-38 131.2 0.2 9.8e-38 129.3 0.4 1.9 2 0 0 2 2 2 1 WD40 associated region in TFIID subunit, NTD2 domain ANAPC4_WD40 PF12894.7 ELR11544.1 - 3.6e-14 52.8 0.0 0.00022 21.4 0.0 5.5 1 1 3 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ELR11544.1 - 3.3e-06 26.3 0.0 0.78 8.6 0.0 4.4 1 1 2 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ELR11544.1 - 4.3e-05 23.0 0.0 6.5 6.0 0.0 4.4 3 2 1 4 4 4 1 WD40-like domain eIF2A PF08662.11 ELR11544.1 - 0.00046 20.1 0.0 0.16 11.8 0.0 2.7 2 1 1 3 3 3 1 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 ELR11544.1 - 0.00052 18.8 1.6 0.45 9.1 0.0 4.1 3 2 1 5 5 5 1 Nucleoporin Nup120/160 Na_trans_assoc PF06512.13 ELR11544.1 - 0.0036 17.6 8.8 0.0059 16.9 8.8 1.3 1 0 0 1 1 1 1 Sodium ion transport-associated Borrelia_P83 PF05262.11 ELR11544.1 - 0.0098 14.4 11.1 0.015 13.8 11.1 1.3 1 0 0 1 1 1 1 Borrelia P83/100 protein PRP21_like_P PF12230.8 ELR11544.1 - 0.083 12.7 16.2 0.15 11.9 16.2 1.3 1 0 0 1 1 1 0 Pre-mRNA splicing factor PRP21 like protein DDHD PF02862.17 ELR11544.1 - 0.092 12.9 1.3 0.15 12.2 1.3 1.4 1 0 0 1 1 1 0 DDHD domain LisH PF08513.11 ELR11544.1 - 0.12 12.3 0.0 0.38 10.8 0.0 1.8 1 0 0 1 1 1 0 LisH SAPS PF04499.15 ELR11544.1 - 0.25 10.1 6.0 0.35 9.6 6.0 1.2 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein DUF2151 PF10221.9 ELR11544.1 - 0.36 9.4 8.3 0.62 8.6 8.3 1.3 1 0 0 1 1 1 0 Cell cycle and development regulator CPSF100_C PF13299.6 ELR11544.1 - 0.37 10.9 9.4 1.2 9.3 9.2 2.0 2 0 0 2 2 1 0 Cleavage and polyadenylation factor 2 C-terminal SLC12 PF03522.15 ELR11544.1 - 0.69 8.9 6.7 1.1 8.2 6.7 1.2 1 0 0 1 1 1 0 Solute carrier family 12 Zip PF02535.22 ELR11544.1 - 1.1 8.4 2.9 1.8 7.7 2.9 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter ATP11 PF06644.11 ELR11544.1 - 1.2 8.9 12.9 2.3 7.9 12.9 1.4 1 0 0 1 1 1 0 ATP11 protein CDC45 PF02724.14 ELR11544.1 - 1.3 7.2 15.2 1.9 6.7 15.2 1.2 1 0 0 1 1 1 0 CDC45-like protein GAGA_bind PF06217.12 ELR11544.1 - 1.4 9.2 7.9 2.5 8.3 7.9 1.4 1 0 0 1 1 1 0 GAGA binding protein-like family Vfa1 PF08432.10 ELR11544.1 - 3.2 8.0 27.0 7.3 6.9 27.0 1.5 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Afi1 PF07792.12 ELR11544.1 - 3.4 8.2 11.1 7.9 7.0 11.1 1.6 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking DUF4407 PF14362.6 ELR11544.1 - 3.4 6.9 6.6 7 5.9 6.6 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) TraV PF09676.10 ELR11544.1 - 3.8 8.5 10.1 12 6.9 10.1 1.8 1 0 0 1 1 1 0 Type IV conjugative transfer system lipoprotein (TraV) Atrophin-1 PF03154.15 ELR11544.1 - 4.6 5.4 19.3 7.8 4.6 19.3 1.3 1 0 0 1 1 1 0 Atrophin-1 family RR_TM4-6 PF06459.12 ELR11544.1 - 5.7 6.7 20.4 10 5.8 20.4 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Tim54 PF11711.8 ELR11544.1 - 5.8 5.6 15.6 9.5 4.9 15.6 1.2 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 MaoC_dehydratas PF01575.19 ELR11545.1 - 4.6e-21 74.6 0.0 6.5e-21 74.2 0.0 1.2 1 0 0 1 1 1 1 MaoC like domain MaoC_dehydrat_N PF13452.6 ELR11545.1 - 0.00017 21.8 0.0 0.00023 21.3 0.0 1.2 1 0 0 1 1 1 1 N-terminal half of MaoC dehydratase F-box-like PF12937.7 ELR11546.1 - 8.3e-09 35.2 0.0 3.2e-08 33.3 0.0 2.1 1 1 0 1 1 1 1 F-box-like F-box PF00646.33 ELR11546.1 - 0.00087 19.1 5.8 0.0094 15.8 5.8 2.4 1 1 0 1 1 1 1 F-box domain LRR_8 PF13855.6 ELR11547.1 - 8.5e-05 22.2 1.7 0.045 13.5 0.1 4.4 4 1 0 4 4 4 1 Leucine rich repeat LRR_6 PF13516.6 ELR11547.1 - 0.00053 19.8 4.0 2.9 8.2 0.0 5.1 6 0 0 6 6 6 1 Leucine Rich repeat LRR_4 PF12799.7 ELR11547.1 - 0.025 15.0 6.5 0.26 11.8 0.2 4.4 3 3 2 5 5 5 0 Leucine Rich repeats (2 copies) FNIP PF05725.12 ELR11547.1 - 0.071 13.3 0.2 25 5.1 0.0 3.4 4 0 0 4 4 4 0 FNIP Repeat LRR_1 PF00560.33 ELR11547.1 - 0.11 13.1 6.6 82 4.4 0.0 5.3 6 0 0 6 6 6 0 Leucine Rich Repeat Voltage_CLC PF00654.20 ELR11548.1 - 5.3e-64 216.7 25.5 5.3e-64 216.7 25.5 2.1 1 1 1 2 2 2 1 Voltage gated chloride channel FixP_N PF14715.6 ELR11548.1 - 0.14 11.9 2.3 0.63 9.8 0.2 2.9 2 0 0 2 2 2 0 N-terminal domain of cytochrome oxidase-cbb3, FixP zf-RING_2 PF13639.6 ELR11549.1 - 1.1e-08 35.3 8.7 1.1e-08 35.3 8.7 3.1 3 1 0 3 3 2 1 Ring finger domain zf-C3HC4_2 PF13923.6 ELR11549.1 - 3e-07 30.2 8.7 3e-07 30.2 8.7 3.3 3 1 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 ELR11549.1 - 9.4e-07 28.6 5.7 9.4e-07 28.6 5.7 2.8 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 ELR11549.1 - 1.3e-05 25.1 2.8 1.3e-05 25.1 2.8 3.2 2 1 1 3 3 3 1 RING-type zinc-finger zf-C3HC4 PF00097.25 ELR11549.1 - 4.4e-05 23.3 7.5 4.4e-05 23.3 7.5 2.8 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 ELR11549.1 - 0.00015 21.6 7.2 0.00015 21.6 7.2 2.8 2 1 0 2 2 2 1 Prokaryotic RING finger family 4 U-box PF04564.15 ELR11549.1 - 0.00015 21.8 0.1 0.0023 18.0 0.1 2.4 2 0 0 2 2 2 1 U-box domain zf-rbx1 PF12678.7 ELR11549.1 - 0.00032 20.9 4.3 0.00032 20.9 4.3 3.6 4 1 0 4 4 3 1 RING-H2 zinc finger domain zf-RING_10 PF16685.5 ELR11549.1 - 0.00091 19.3 6.0 0.00091 19.3 6.0 2.1 2 0 0 2 2 2 1 zinc RING finger of MSL2 zf-RING_6 PF14835.6 ELR11549.1 - 0.002 18.0 2.5 0.002 18.0 2.5 2.4 3 1 0 3 3 2 1 zf-RING of BARD1-type protein zf-TRAF_2 PF15965.5 ELR11549.1 - 0.002 18.6 1.3 0.002 18.6 1.3 2.8 2 1 0 2 2 2 1 TRAF-like zinc-finger zf-RING_5 PF14634.6 ELR11549.1 - 0.0044 17.0 5.8 0.0044 17.0 5.8 3.1 3 1 0 3 3 2 1 zinc-RING finger domain zf-ANAPC11 PF12861.7 ELR11549.1 - 0.011 15.8 1.6 0.011 15.8 1.6 3.0 3 2 0 3 3 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger HypA PF01155.19 ELR11549.1 - 0.018 15.1 11.3 0.058 13.4 0.3 3.0 2 1 0 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-Nse PF11789.8 ELR11549.1 - 0.024 14.5 3.5 0.024 14.5 3.5 2.9 3 0 0 3 3 3 0 Zinc-finger of the MIZ type in Nse subunit Sina PF03145.16 ELR11549.1 - 0.098 12.6 0.9 0.18 11.7 0.9 1.5 1 0 0 1 1 1 0 Seven in absentia protein family Prok-RING_1 PF14446.6 ELR11549.1 - 0.17 11.8 17.1 3.9 7.5 7.7 3.8 2 1 0 2 2 2 0 Prokaryotic RING finger family 1 zf-TRAF PF02176.18 ELR11549.1 - 0.19 12.4 18.5 0.13 12.9 1.9 3.3 3 1 0 3 3 3 0 TRAF-type zinc finger DUF1244 PF06844.11 ELR11549.1 - 0.39 10.9 2.5 0.4 10.9 0.4 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1244) zf-C3HC4_4 PF15227.6 ELR11549.1 - 0.5 10.6 20.2 0.074 13.2 10.1 2.7 2 0 0 2 2 2 0 zinc finger of C3HC4-type, RING Zn_ribbon_SprT PF17283.2 ELR11549.1 - 0.83 9.6 7.3 5.5 7.0 2.7 3.7 3 0 0 3 3 3 0 SprT-like zinc ribbon domain Anti-TRAP PF15777.5 ELR11549.1 - 6.4 6.8 13.3 0.15 12.0 0.8 3.4 3 1 0 3 3 3 0 Tryptophan RNA-binding attenuator protein inhibitory protein zf-U11-48K PF05253.12 ELR11549.1 - 8.2 6.5 8.1 1.7 8.7 0.2 2.9 3 0 0 3 3 3 0 U11-48K-like CHHC zinc finger CTP_transf_like PF01467.26 ELR11550.1 - 1.4e-06 28.5 0.0 2.4e-06 27.8 0.0 1.4 1 0 0 1 1 1 1 Cytidylyltransferase-like CTP_transf_like PF01467.26 ELR11551.1 - 6.1e-06 26.5 0.0 2e-05 24.8 0.0 1.9 1 1 0 1 1 1 1 Cytidylyltransferase-like PNP_phzG_C PF10590.9 ELR11552.1 - 2.3e-06 27.6 0.1 5.3e-06 26.4 0.1 1.7 1 0 0 1 1 1 1 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region Putative_PNPOx PF01243.20 ELR11552.1 - 0.0037 17.4 0.0 0.0062 16.7 0.0 1.3 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Putative_PNPOx PF01243.20 ELR11553.1 - 1.4e-12 47.6 0.0 3.1e-12 46.5 0.0 1.6 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase CTP_transf_like PF01467.26 ELR11553.1 - 3.9e-06 27.1 0.0 9.6e-06 25.8 0.0 1.7 2 0 0 2 2 2 1 Cytidylyltransferase-like PNP_phzG_C PF10590.9 ELR11553.1 - 7.5e-05 22.7 0.1 0.00016 21.7 0.1 1.6 1 0 0 1 1 1 1 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region Pyridox_oxase_2 PF12766.7 ELR11553.1 - 0.16 12.6 0.0 0.55 10.9 0.0 1.9 2 0 0 2 2 2 0 Pyridoxamine 5'-phosphate oxidase Ribonuclease_T2 PF00445.18 ELR11554.1 - 3.9e-50 170.6 0.0 5e-50 170.3 0.0 1.1 1 0 0 1 1 1 1 Ribonuclease T2 family C6_DPF PF10170.9 ELR11555.1 - 1e-25 89.9 1.9 1.2e-25 89.7 1.9 1.0 1 0 0 1 1 1 1 Cysteine-rich domain zf-3CxxC_2 PF17180.4 ELR11556.1 - 3.1e-13 50.3 12.9 3.1e-13 50.3 12.9 2.1 1 1 1 3 3 3 1 Zinc-binding domain Elf1 PF05129.13 ELR11556.1 - 0.0013 18.7 3.2 0.0013 18.7 3.2 3.0 1 1 2 3 3 3 1 Transcription elongation factor Elf1 like zf-3CxxC PF13695.6 ELR11556.1 - 0.23 11.9 21.8 0.57 10.7 18.1 2.8 2 1 0 2 2 2 0 Zinc-binding domain Umbravirus_LDM PF04817.12 ELR11556.1 - 1.6 8.1 7.6 0.5 9.7 0.5 2.1 2 0 0 2 2 2 0 Umbravirus long distance movement (LDM) family Gelsolin PF00626.22 ELR11557.1 - 3.8e-15 55.5 0.1 0.001 18.9 0.0 4.2 3 1 0 3 3 3 3 Gelsolin repeat GlutR_dimer PF00745.20 ELR11557.1 - 0.04 14.4 2.6 0.087 13.3 2.6 1.6 1 0 0 1 1 1 0 Glutamyl-tRNAGlu reductase, dimerisation domain FAD-oxidase_C PF02913.19 ELR11559.1 - 1.8e-29 103.1 0.0 2.4e-29 102.7 0.0 1.1 1 0 0 1 1 1 1 FAD linked oxidases, C-terminal domain FAD-oxidase_C PF02913.19 ELR11561.1 - 4.9e-43 147.6 0.0 7.1e-43 147.0 0.0 1.3 1 0 0 1 1 1 1 FAD linked oxidases, C-terminal domain FAD_binding_4 PF01565.23 ELR11561.1 - 3.9e-36 123.9 0.0 8.1e-36 122.8 0.0 1.5 1 0 0 1 1 1 1 FAD binding domain CCDC144C PF14915.6 ELR11562.1 - 0.18 10.9 0.1 0.25 10.4 0.1 1.1 1 0 0 1 1 1 0 CCDC144C protein coiled-coil region Melibiase_2 PF16499.5 ELR11563.1 - 3e-90 302.2 5.4 1.8e-78 263.6 0.7 2.1 1 1 1 2 2 2 2 Alpha galactosidase A Melibiase_C PF17801.1 ELR11563.1 - 3.4e-18 65.5 1.3 3.4e-18 65.5 1.3 2.1 2 0 0 2 2 2 1 Alpha galactosidase C-terminal beta sandwich domain Melibiase_2_C PF17450.2 ELR11563.1 - 1.2e-07 31.9 0.0 2.2e-07 31.0 0.0 1.5 1 0 0 1 1 1 1 Alpha galactosidase A C-terminal beta sandwich domain SLT_L PF14718.6 ELR11563.1 - 0.08 13.1 2.5 0.43 10.8 2.0 2.2 2 0 0 2 2 2 0 Soluble lytic murein transglycosylase L domain NOA36 PF06524.12 ELR11564.1 - 0.016 14.5 3.3 0.034 13.5 3.3 1.5 1 0 0 1 1 1 0 NOA36 protein PI3K_1B_p101 PF10486.9 ELR11564.1 - 0.2 9.4 0.3 0.33 8.7 0.3 1.2 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit zf-C2HC PF01530.18 ELR11564.1 - 0.47 10.7 2.2 13 6.1 0.1 3.0 2 0 0 2 2 2 0 Zinc finger, C2HC type LRR_8 PF13855.6 ELR11564.1 - 0.88 9.4 17.0 9.4 6.1 0.0 7.4 10 0 0 10 10 10 0 Leucine rich repeat DNA_pol_phi PF04931.13 ELR11564.1 - 2.9 5.9 6.4 4.5 5.2 6.4 1.2 1 0 0 1 1 1 0 DNA polymerase phi Oxidored_FMN PF00724.20 ELR11565.1 - 1.6e-76 257.8 0.0 1.9e-76 257.6 0.0 1.0 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family Dus PF01207.17 ELR11565.1 - 0.043 12.9 0.0 0.11 11.6 0.0 1.6 2 0 0 2 2 2 0 Dihydrouridine synthase (Dus) S8_pro-domain PF16470.5 ELR11566.1 - 1.3e-18 67.5 1.4 1.8e-18 67.1 1.4 1.1 1 0 0 1 1 1 1 Peptidase S8 pro-domain Pilin_N PF07790.11 ELR11566.1 - 0.12 13.3 0.0 0.22 12.4 0.0 1.4 1 1 0 1 1 1 0 Archaeal Type IV pilin, N-terminal Hydantoinase_B PF02538.14 ELR11567.1 - 2.5e-213 709.2 1.2 3.2e-213 708.8 1.2 1.1 1 0 0 1 1 1 1 Hydantoinase B/oxoprolinase Hydantoinase_A PF01968.18 ELR11567.1 - 1.1e-106 356.3 0.3 4.7e-106 354.3 0.0 2.2 3 0 0 3 3 3 1 Hydantoinase/oxoprolinase Hydant_A_N PF05378.13 ELR11567.1 - 5.1e-63 212.0 1.6 9.9e-62 207.8 0.0 2.6 3 0 0 3 3 3 1 Hydantoinase/oxoprolinase N-terminal region Ras PF00071.22 ELR11568.1 - 7.8e-06 25.6 0.0 0.00022 20.8 0.0 2.1 1 1 1 2 2 2 2 Ras family F-box-like PF12937.7 ELR11568.1 - 0.0011 18.8 1.2 0.0019 18.0 1.2 1.4 1 0 0 1 1 1 1 F-box-like MMR_HSR1 PF01926.23 ELR11568.1 - 0.11 12.6 0.0 0.19 11.8 0.0 1.4 1 0 0 1 1 1 0 50S ribosome-binding GTPase CstA PF02554.14 ELR11569.1 - 0.042 12.7 0.4 0.047 12.6 0.4 1.1 1 0 0 1 1 1 0 Carbon starvation protein CstA WHIM1 PF15612.6 ELR11569.1 - 0.065 12.8 0.3 0.12 12.0 0.3 1.5 1 0 0 1 1 1 0 WSTF, HB1, Itc1p, MBD9 motif 1 GSG-1 PF07803.11 ELR11569.1 - 0.15 12.0 0.6 0.22 11.4 0.5 1.4 1 1 0 1 1 1 0 GSG1-like protein BRCT_2 PF16589.5 ELR11571.1 - 5.2e-14 52.4 0.0 2e-05 24.9 0.0 2.8 2 0 0 2 2 2 2 BRCT domain, a BRCA1 C-terminus domain BRCT PF00533.26 ELR11571.1 - 1.1e-12 48.2 0.0 4.8e-05 23.7 0.0 2.6 2 0 0 2 2 2 2 BRCA1 C Terminus (BRCT) domain LIG3_BRCT PF16759.5 ELR11571.1 - 2.1e-10 40.8 0.1 1.8e-07 31.3 0.2 2.6 2 0 0 2 2 2 2 DNA ligase 3 BRCT domain PTCB-BRCT PF12738.7 ELR11571.1 - 1.3e-09 37.9 0.2 0.00046 20.1 0.1 2.8 2 0 0 2 2 2 2 twin BRCT domain Med8 PF10232.9 ELR11571.1 - 0.019 14.6 6.6 0.28 10.8 3.8 2.2 2 0 0 2 2 2 0 Mediator of RNA polymerase II transcription complex subunit 8 TFIIA PF03153.13 ELR11571.1 - 0.022 14.8 8.1 0.035 14.1 8.1 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit BUD22 PF09073.10 ELR11571.1 - 0.033 13.5 19.2 0.076 12.4 19.2 1.6 1 1 0 1 1 1 0 BUD22 SDA1 PF05285.12 ELR11571.1 - 0.061 12.8 18.5 0.086 12.3 2.8 2.1 2 0 0 2 2 2 0 SDA1 PTPRCAP PF15713.5 ELR11571.1 - 0.12 12.7 12.6 0.16 12.2 0.7 2.5 2 0 0 2 2 2 0 Protein tyrosine phosphatase receptor type C-associated Nop14 PF04147.12 ELR11571.1 - 0.78 7.9 16.8 0.053 11.7 3.7 2.1 2 0 0 2 2 2 0 Nop14-like family CDC45 PF02724.14 ELR11571.1 - 2.3 6.4 20.0 0.37 9.0 3.7 2.1 2 0 0 2 2 2 0 CDC45-like protein Dicty_REP PF05086.12 ELR11571.1 - 3 5.7 11.4 0.2 9.6 1.0 2.1 2 0 0 2 2 2 0 Dictyostelium (Slime Mold) REP protein TEX19 PF15553.6 ELR11571.1 - 3.5 7.6 6.6 0.29 11.1 0.5 2.2 2 1 0 2 2 2 0 Testis-expressed protein 19 Zip PF02535.22 ELR11571.1 - 3.8 6.6 4.3 2.3 7.3 0.5 2.0 2 0 0 2 2 2 0 ZIP Zinc transporter DUF4604 PF15377.6 ELR11571.1 - 4.6 7.6 20.3 0.78 10.1 0.3 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4604) DNA_ligase_A_M PF01068.21 ELR11572.1 - 1.4e-52 178.3 0.9 2.3e-52 177.6 0.9 1.3 1 0 0 1 1 1 1 ATP dependent DNA ligase domain DNA_ligase_A_C PF04679.15 ELR11572.1 - 4e-18 65.8 0.1 1.1e-17 64.4 0.1 1.8 1 0 0 1 1 1 1 ATP dependent DNA ligase C terminal region DNA_ligase_A_N PF04675.14 ELR11572.1 - 1.2e-13 51.8 0.1 2.7e-13 50.6 0.1 1.6 1 0 0 1 1 1 1 DNA ligase N terminus RNA_ligase PF09414.10 ELR11572.1 - 1.8e-07 31.6 0.1 4.4e-07 30.4 0.1 1.6 1 0 0 1 1 1 1 RNA ligase mRNA_cap_enzyme PF01331.19 ELR11572.1 - 0.00017 21.4 0.2 0.0006 19.7 0.2 2.0 1 1 0 1 1 1 1 mRNA capping enzyme, catalytic domain GDA1_CD39 PF01150.17 ELR11572.1 - 0.043 12.5 0.0 0.076 11.7 0.0 1.3 1 0 0 1 1 1 0 GDA1/CD39 (nucleoside phosphatase) family KH_8 PF17903.1 ELR11573.1 - 5.5e-09 36.0 0.0 7.7e-09 35.5 0.0 1.2 1 0 0 1 1 1 1 Krr1 KH1 domain KH_8 PF17903.1 ELR11574.1 - 2e-31 107.9 0.0 5.4e-31 106.5 0.0 1.8 1 0 0 1 1 1 1 Krr1 KH1 domain KH_1 PF00013.29 ELR11574.1 - 0.0011 18.7 0.0 0.0028 17.4 0.0 1.7 1 0 0 1 1 1 1 KH domain KH_4 PF13083.6 ELR11574.1 - 0.12 12.2 0.0 0.3 11.0 0.0 1.7 1 0 0 1 1 1 0 KH domain DSPc PF00782.20 ELR11575.1 - 1.4e-31 109.1 0.0 2.2e-31 108.4 0.0 1.3 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain LRR_8 PF13855.6 ELR11575.1 - 3e-26 90.9 29.5 3.6e-08 33.0 0.4 8.1 6 1 3 9 9 9 7 Leucine rich repeat LRR_4 PF12799.7 ELR11575.1 - 2.9e-21 75.2 25.3 5.3e-05 23.5 0.3 8.3 5 2 1 7 7 7 6 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 ELR11575.1 - 3.2e-05 23.9 27.7 2.3 9.1 0.5 9.6 10 1 0 10 10 10 3 Leucine Rich Repeat LRR_9 PF14580.6 ELR11575.1 - 9.5e-05 22.0 6.3 0.035 13.6 0.1 3.7 4 1 0 4 4 4 2 Leucine-rich repeat DNA_ligase_A_N PF04675.14 ELR11575.1 - 0.00013 22.4 0.0 0.00036 20.9 0.0 1.7 1 0 0 1 1 1 1 DNA ligase N terminus Y_phosphatase PF00102.27 ELR11575.1 - 0.0038 16.8 0.0 0.0063 16.1 0.0 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase LRR_6 PF13516.6 ELR11575.1 - 0.0078 16.2 46.8 0.47 10.6 0.2 10.5 11 0 0 11 11 11 3 Leucine Rich repeat DUF5489 PF17592.2 ELR11575.1 - 0.19 12.3 0.2 52 4.5 0.0 3.1 3 0 0 3 3 3 0 Family of unknown function (DUF5489) Ras PF00071.22 ELR11576.1 - 3.6e-46 156.7 0.0 4.6e-34 117.4 0.0 2.6 2 0 0 2 2 2 2 Ras family Roc PF08477.13 ELR11576.1 - 4.7e-16 59.1 0.0 5.9e-09 36.2 0.0 2.9 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase VWA_2 PF13519.6 ELR11576.1 - 1.8e-07 31.7 0.6 0.059 14.0 0.0 4.4 3 1 0 4 4 4 2 von Willebrand factor type A domain Arf PF00025.21 ELR11576.1 - 1.4e-05 24.6 0.0 6.1e-05 22.5 0.0 2.1 1 1 1 2 2 2 1 ADP-ribosylation factor family Sec23_BS PF08033.12 ELR11576.1 - 0.00016 22.4 0.1 0.00046 20.9 0.1 1.8 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain RsgA_GTPase PF03193.16 ELR11576.1 - 0.00044 20.2 0.0 0.0014 18.5 0.0 1.8 2 0 0 2 2 2 1 RsgA GTPase SAM_2 PF07647.17 ELR11576.1 - 0.0013 18.8 0.0 0.0027 17.8 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) VWA_CoxE PF05762.14 ELR11576.1 - 0.0057 16.1 0.2 1.9 7.8 0.1 2.8 3 0 0 3 3 3 2 VWA domain containing CoxE-like protein VWA PF00092.28 ELR11576.1 - 0.0079 16.5 0.1 2.3 8.5 0.0 3.6 4 0 0 4 4 4 1 von Willebrand factor type A domain zf-met PF12874.7 ELR11578.1 - 0.0042 17.4 0.8 0.0062 16.9 0.8 1.3 1 0 0 1 1 1 1 Zinc-finger of C2H2 type GGACT PF06094.12 ELR11579.1 - 7.5e-16 58.8 0.0 1.5e-15 57.8 0.0 1.5 1 1 0 1 1 1 1 Gamma-glutamyl cyclotransferase, AIG2-like AIG2_2 PF13772.6 ELR11579.1 - 0.02 15.3 0.0 0.046 14.1 0.0 1.6 2 0 0 2 2 2 0 AIG2-like family TPR_14 PF13428.6 ELR11580.1 - 4.1e-08 33.4 30.0 0.0045 17.7 0.2 10.8 8 1 1 9 9 9 4 Tetratricopeptide repeat zf-C3H1 PF10650.9 ELR11580.1 - 5.2e-08 32.5 4.3 1.1e-07 31.4 4.3 1.6 1 0 0 1 1 1 1 Putative zinc-finger domain TPR_19 PF14559.6 ELR11580.1 - 1.8e-07 31.5 13.1 0.19 12.3 0.0 6.8 5 1 1 6 6 6 3 Tetratricopeptide repeat TPR_17 PF13431.6 ELR11580.1 - 0.0012 19.1 1.4 30 5.3 0.0 5.8 5 0 0 5 5 5 1 Tetratricopeptide repeat ALAD PF00490.21 ELR11581.1 - 1.8e-128 428.2 0.0 2.1e-128 428.0 0.0 1.0 1 0 0 1 1 1 1 Delta-aminolevulinic acid dehydratase 14-3-3 PF00244.20 ELR11582.1 - 8.8e-93 309.9 2.7 1e-92 309.7 2.7 1.0 1 0 0 1 1 1 1 14-3-3 protein FlaF PF07309.11 ELR11582.1 - 0.043 13.8 0.5 0.22 11.6 0.0 2.1 2 1 0 2 2 2 0 Flagellar protein FlaF CRISPR_Cse1 PF09481.10 ELR11582.1 - 0.14 11.2 0.4 0.21 10.7 0.4 1.3 1 0 0 1 1 1 0 CRISPR-associated protein Cse1 (CRISPR_cse1) Pkinase PF00069.25 ELR11583.1 - 2.4e-22 79.6 0.0 1.3e-21 77.2 0.0 2.1 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR11583.1 - 2.1e-18 66.5 0.0 1.6e-17 63.7 0.0 2.2 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 ELR11583.1 - 2.8e-08 33.4 0.0 4.7e-08 32.7 0.0 1.2 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 ELR11583.1 - 0.0036 17.3 0.2 0.011 15.7 0.2 1.8 1 0 0 1 1 1 1 Phosphotransferase enzyme family DUF3422 PF11902.8 ELR11583.1 - 0.037 13.2 1.3 0.067 12.3 1.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3422) CASP_C PF08172.12 ELR11583.1 - 0.062 12.6 2.1 0.21 10.9 0.0 2.6 2 0 0 2 2 2 0 CASP C terminal Nop25 PF09805.9 ELR11584.1 - 2.8e-13 50.5 30.8 2.8e-13 50.5 30.8 3.3 2 2 1 3 3 3 1 Nucleolar protein 12 (25kDa) DUF2457 PF10446.9 ELR11584.1 - 7.8e-05 22.0 4.3 7.8e-05 22.0 4.3 3.2 2 1 0 3 3 3 1 Protein of unknown function (DUF2457) V-ATPase_G PF03179.15 ELR11584.1 - 0.034 14.7 4.1 0.034 14.7 4.1 2.4 3 0 0 3 3 3 0 Vacuolar (H+)-ATPase G subunit Phage_holin_2_4 PF16082.5 ELR11584.1 - 0.035 13.8 0.5 0.035 13.8 0.5 2.4 2 0 0 2 2 2 0 Bacteriophage holin family, superfamily II-like ATP-synt_ab PF00006.25 ELR11585.1 - 2.6e-37 128.6 0.0 3.9e-37 128.0 0.0 1.3 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_Xtn PF16886.5 ELR11585.1 - 1.3e-27 96.0 0.0 2.9e-27 94.9 0.0 1.5 1 0 0 1 1 1 1 ATPsynthase alpha/beta subunit N-term extension ATP-synt_ab_N PF02874.23 ELR11585.1 - 0.0043 17.5 4.6 0.014 15.9 2.7 2.6 2 1 0 2 2 2 1 ATP synthase alpha/beta family, beta-barrel domain Acetyltransf_1 PF00583.25 ELR11586.1 - 8.5e-10 38.9 0.0 1e-09 38.6 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 ELR11586.1 - 1.3e-07 31.9 0.0 2e-07 31.4 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 ELR11586.1 - 4.8e-07 29.8 0.1 6e-07 29.5 0.1 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 ELR11586.1 - 0.011 15.8 0.0 0.013 15.6 0.0 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 ELR11586.1 - 0.036 14.2 0.0 0.062 13.4 0.0 1.4 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase AMP-binding PF00501.28 ELR11587.1 - 9.2e-62 209.0 0.0 3.6e-60 203.7 0.0 2.2 2 0 0 2 2 2 1 AMP-binding enzyme NAD_binding_4 PF07993.12 ELR11587.1 - 1.1e-52 178.8 0.0 8.2e-52 175.9 0.0 2.4 2 1 0 2 2 2 1 Male sterility protein PP-binding PF00550.25 ELR11587.1 - 4.7e-10 39.7 0.3 1.1e-09 38.4 0.3 1.7 1 0 0 1 1 1 1 Phosphopantetheine attachment site Epimerase PF01370.21 ELR11587.1 - 0.00018 21.1 0.0 0.00032 20.2 0.0 1.4 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family AMP-binding_C PF13193.6 ELR11587.1 - 0.015 16.2 0.5 0.015 16.2 0.5 2.8 2 1 0 2 2 2 0 AMP-binding enzyme C-terminal domain DUF4746 PF15928.5 ELR11587.1 - 0.035 13.5 1.5 0.19 11.2 0.8 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4746) DUF3464 PF11947.8 ELR11587.1 - 0.1 12.4 0.6 0.22 11.2 0.6 1.5 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 3Beta_HSD PF01073.19 ELR11587.1 - 0.12 11.4 0.0 0.26 10.3 0.0 1.6 1 1 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family Chloroplast_duf PF14476.6 ELR11587.1 - 0.21 10.5 2.0 0.49 9.3 2.0 1.5 1 0 0 1 1 1 0 Petal formation-expressed AP3D1 PF06375.11 ELR11587.1 - 5.6 7.2 10.5 15 5.8 10.5 1.6 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 CitMHS PF03600.16 ELR11588.1 - 9.3e-36 123.6 12.3 1.5e-35 122.8 12.3 1.3 1 0 0 1 1 1 1 Citrate transporter Parvo_coat PF00740.18 ELR11588.1 - 0.31 9.6 1.4 0.44 9.1 1.4 1.1 1 0 0 1 1 1 0 Parvovirus coat protein VP2 TraB PF01963.17 ELR11589.1 - 5.1e-13 49.5 0.1 1.8e-09 37.9 0.1 2.2 2 0 0 2 2 2 2 TraB family DUF3069 PF11269.8 ELR11589.1 - 0.0085 16.3 1.0 0.016 15.5 1.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3069) PepX_N PF09168.10 ELR11589.1 - 0.035 14.5 1.1 0.15 12.4 0.0 2.0 1 1 1 2 2 2 0 X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal CPV_Polyhedrin PF17515.2 ELR11589.1 - 0.07 12.5 0.3 0.093 12.1 0.3 1.1 1 0 0 1 1 1 0 Cypovirus polyhedrin Ank_4 PF13637.6 ELR11590.1 - 2.4e-14 53.5 8.6 0.12 13.0 0.0 8.3 6 2 3 9 9 9 5 Ankyrin repeats (many copies) Ank_2 PF12796.7 ELR11590.1 - 6.5e-11 42.7 1.1 0.1 13.2 0.0 4.9 3 2 2 5 5 5 4 Ankyrin repeats (3 copies) Ank_5 PF13857.6 ELR11590.1 - 1.3e-08 34.9 6.9 0.72 10.3 0.1 7.9 7 1 2 9 9 9 3 Ankyrin repeats (many copies) F-box PF00646.33 ELR11590.1 - 0.00036 20.3 0.2 0.00069 19.4 0.2 1.4 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 ELR11590.1 - 0.00065 19.5 0.4 0.0016 18.3 0.4 1.7 1 0 0 1 1 1 1 F-box-like Ank_3 PF13606.6 ELR11590.1 - 0.0045 17.4 0.4 7.9 7.4 0.0 5.2 6 0 0 6 6 6 1 Ankyrin repeat BrnA_antitoxin PF14384.6 ELR11590.1 - 0.19 12.2 2.2 88 3.7 0.0 5.2 7 0 0 7 7 7 0 BrnA antitoxin of type II toxin-antitoxin system CXCXC PF03128.14 ELR11590.1 - 0.24 11.9 11.9 16 6.2 0.2 6.0 6 0 0 6 6 6 0 CXCXC repeat DUF1084 PF06454.11 ELR11591.1 - 3.2e-11 43.1 23.1 6.9e-08 32.2 9.0 2.2 2 0 0 2 2 2 2 Protein of unknown function (DUF1084) DUF5082 PF16888.5 ELR11592.1 - 0.26 11.6 11.0 0.74 10.1 3.2 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF5082) SDA1 PF05285.12 ELR11592.1 - 0.97 8.8 21.0 1.3 8.4 21.0 1.1 1 0 0 1 1 1 0 SDA1 Nop14 PF04147.12 ELR11592.1 - 1.8 6.6 19.1 2.3 6.3 19.1 1.1 1 0 0 1 1 1 0 Nop14-like family Presenilin PF01080.17 ELR11592.1 - 8.3 5.1 7.0 10 4.8 7.0 1.1 1 0 0 1 1 1 0 Presenilin Methyltr_RsmB-F PF01189.17 ELR11593.1 - 5.4e-24 85.0 0.1 5.6e-23 81.6 0.1 2.6 2 1 0 2 2 2 1 16S rRNA methyltransferase RsmB/F BUD22 PF09073.10 ELR11593.1 - 1e-06 28.4 10.3 0.0013 18.1 2.4 2.2 2 0 0 2 2 2 2 BUD22 DDHD PF02862.17 ELR11593.1 - 0.0014 18.8 4.0 0.019 15.1 0.4 2.2 2 0 0 2 2 2 1 DDHD domain FtsJ PF01728.19 ELR11593.1 - 0.0018 18.4 0.1 0.0048 17.0 0.0 1.7 2 0 0 2 2 2 1 FtsJ-like methyltransferase SR-25 PF10500.9 ELR11593.1 - 0.0037 16.9 28.7 0.011 15.3 17.0 2.2 2 0 0 2 2 2 2 Nuclear RNA-splicing-associated protein DTHCT PF08070.11 ELR11593.1 - 0.019 15.7 6.3 0.019 15.7 6.3 3.3 2 1 1 3 3 2 0 DTHCT (NUC029) region RNA_pol_Rpc4 PF05132.14 ELR11593.1 - 0.028 14.9 13.8 0.34 11.3 6.2 2.3 2 0 0 2 2 2 0 RNA polymerase III RPC4 DUF572 PF04502.13 ELR11593.1 - 0.04 13.6 12.7 0.12 12.0 1.8 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF572) SAPS PF04499.15 ELR11593.1 - 0.058 12.2 4.7 0.16 10.7 0.6 2.1 2 0 0 2 2 2 0 SIT4 phosphatase-associated protein Methyltransf_31 PF13847.6 ELR11593.1 - 0.059 13.2 0.0 0.16 11.8 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain RNA_polI_A34 PF08208.11 ELR11593.1 - 0.096 12.8 28.4 0.43 10.6 8.0 2.3 2 0 0 2 2 2 0 DNA-directed RNA polymerase I subunit RPA34.5 CCDC106 PF15794.5 ELR11593.1 - 0.14 11.8 24.9 0.35 10.6 9.6 2.4 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 106 Hid1 PF12722.7 ELR11593.1 - 0.23 9.5 5.6 0.76 7.8 0.7 2.1 2 0 0 2 2 2 0 High-temperature-induced dauer-formation protein DUF4604 PF15377.6 ELR11593.1 - 0.35 11.3 26.4 1.1 9.7 7.4 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4604) Coilin_N PF15862.5 ELR11593.1 - 0.93 9.3 20.1 1.2 9.0 2.4 2.5 2 0 0 2 2 2 0 Coilin N-terminus DUF913 PF06025.12 ELR11593.1 - 1.3 7.9 7.6 0.9 8.4 1.7 2.1 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) Apt1 PF10351.9 ELR11593.1 - 1.4 7.7 14.2 1.8 7.3 1.1 2.1 2 0 0 2 2 2 0 Golgi-body localisation protein domain Neur_chan_memb PF02932.16 ELR11593.1 - 1.4 8.9 5.8 2 8.4 1.2 2.3 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region DUF4778 PF16008.5 ELR11593.1 - 2.1 8.4 9.4 0.39 10.7 0.5 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4778) RR_TM4-6 PF06459.12 ELR11593.1 - 5 6.9 18.9 2.7 7.8 9.7 2.2 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 DAG_kinase_N PF14513.6 ELR11593.1 - 5.8 7.1 10.9 4.5 7.5 1.9 2.4 2 0 0 2 2 2 0 Diacylglycerol kinase N-terminus eIF3_subunit PF08597.10 ELR11593.1 - 7.9 6.3 25.7 0.44 10.4 3.3 2.3 2 0 0 2 2 2 0 Translation initiation factor eIF3 subunit DUF3807 PF12720.7 ELR11593.1 - 8.8 6.6 22.9 2.2 8.5 7.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3807) FKBP_C PF00254.28 ELR11594.1 - 3.4e-31 107.4 0.2 5.5e-31 106.7 0.2 1.3 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase BTHB PF18410.1 ELR11594.1 - 5.1e-21 74.3 0.5 8.7e-21 73.5 0.5 1.4 1 0 0 1 1 1 1 Basic tilted helix bundle domain FKBP_N_2 PF18023.1 ELR11594.1 - 0.028 14.5 0.0 0.057 13.5 0.0 1.5 1 0 0 1 1 1 0 BDBT FKBP like N-terminal CBS PF00571.28 ELR11595.1 - 4.4e-13 49.4 0.4 9.8e-06 25.9 0.0 4.4 5 0 0 5 5 5 2 CBS domain Mannosyl_trans2 PF04188.13 ELR11596.1 - 2e-78 264.7 18.0 2.5e-50 172.1 5.4 2.0 2 0 0 2 2 2 2 Mannosyltransferase (PIG-V) SPX PF03105.19 ELR11596.1 - 0.024 14.5 0.1 0.043 13.7 0.1 1.4 1 0 0 1 1 1 0 SPX domain GWT1 PF06423.12 ELR11596.1 - 0.061 13.4 1.5 2.5 8.2 1.5 2.8 1 1 0 1 1 1 0 GWT1 BatD PF13584.6 ELR11596.1 - 0.16 10.7 0.1 0.76 8.5 0.1 1.9 2 0 0 2 2 2 0 Oxygen tolerance Apt1 PF10351.9 ELR11596.1 - 0.31 9.8 1.1 0.49 9.2 1.1 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain Rrn6 PF10214.9 ELR11596.1 - 0.43 9.0 7.2 0.2 10.1 0.4 2.1 2 0 0 2 2 2 0 RNA polymerase I-specific transcription-initiation factor stn_TNFRSF12A PF12191.8 ELR11596.1 - 0.86 9.8 3.3 0.73 10.1 0.4 2.3 3 0 0 3 3 3 0 Tumour necrosis factor receptor stn_TNFRSF12A_TNFR domain DUF508 PF04370.12 ELR11596.1 - 9.6 5.9 11.9 0.52 10.0 6.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF508) TPR_MLP1_2 PF07926.12 ELR11597.1 - 0.0016 18.5 10.9 0.0016 18.5 10.9 3.0 1 1 1 2 2 2 1 TPR/MLP1/MLP2-like protein Sec8_exocyst PF04048.14 ELR11597.1 - 0.017 15.0 1.9 0.037 13.9 1.9 1.5 1 0 0 1 1 1 0 Sec8 exocyst complex component specific domain CENP-B_dimeris PF09026.10 ELR11597.1 - 0.21 12.0 11.2 0.81 10.1 11.4 1.7 2 0 0 2 2 2 0 Centromere protein B dimerisation domain DUF5339 PF17274.2 ELR11597.1 - 1.8 9.5 6.3 3.7 8.5 0.3 2.5 2 1 0 2 2 2 0 Family of unknown function (DUF5339) NOA36 PF06524.12 ELR11597.1 - 2.2 7.5 10.7 3.4 6.9 10.7 1.3 1 0 0 1 1 1 0 NOA36 protein FAM184 PF15665.5 ELR11597.1 - 2.9 7.6 26.7 0.36 10.6 10.4 2.1 1 1 0 2 2 2 0 Family with sequence similarity 184, A and B V_ATPase_I PF01496.19 ELR11597.1 - 6.4 4.6 8.4 6.8 4.5 8.4 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family PH PF00169.29 ELR11598.1 - 5.7e-14 52.5 0.0 9.8e-14 51.7 0.0 1.4 2 0 0 2 2 2 1 PH domain PH_8 PF15409.6 ELR11598.1 - 4.6e-09 36.4 0.0 5.9e-09 36.1 0.0 1.1 1 0 0 1 1 1 1 Pleckstrin homology domain PH_3 PF14593.6 ELR11598.1 - 3.8e-05 23.7 0.0 5.2e-05 23.3 0.0 1.2 1 0 0 1 1 1 1 PH domain PH_6 PF15406.6 ELR11598.1 - 0.0061 16.8 0.0 0.011 16.0 0.0 1.4 1 0 0 1 1 1 1 Pleckstrin homology domain Mcp5_PH PF12814.7 ELR11598.1 - 0.0062 16.7 0.0 0.017 15.2 0.0 1.7 1 1 0 1 1 1 1 Meiotic cell cortex C-terminal pleckstrin homology PH_12 PF16457.5 ELR11598.1 - 0.014 16.0 0.8 4.6 7.8 0.0 2.3 1 1 1 2 2 2 0 Pleckstrin homology domain UPF0242 PF06785.11 ELR11599.1 - 0.0022 18.2 0.0 0.0035 17.5 0.0 1.3 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0242) N-terminus Myosin_tail_1 PF01576.19 ELR11599.1 - 0.0039 15.1 1.3 0.0049 14.7 1.3 1.0 1 0 0 1 1 1 1 Myosin tail Trimer_CC PF08954.11 ELR11599.1 - 0.0065 16.0 3.7 0.015 14.9 3.7 1.6 1 0 0 1 1 1 1 Trimerisation motif ERM PF00769.19 ELR11599.1 - 0.007 16.2 1.9 0.01 15.7 1.9 1.2 1 0 0 1 1 1 1 Ezrin/radixin/moesin family Lebercilin PF15619.6 ELR11599.1 - 0.01 15.5 2.2 0.015 14.9 2.2 1.2 1 0 0 1 1 1 0 Ciliary protein causing Leber congenital amaurosis disease DUF641 PF04859.12 ELR11599.1 - 0.015 15.6 0.3 0.024 15.0 0.3 1.2 1 0 0 1 1 1 0 Plant protein of unknown function (DUF641) DUF5082 PF16888.5 ELR11599.1 - 0.048 13.9 0.2 0.075 13.3 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF5082) Sec2p PF06428.11 ELR11599.1 - 0.052 13.5 1.2 0.092 12.7 1.2 1.4 1 0 0 1 1 1 0 GDP/GTP exchange factor Sec2p ADIP PF11559.8 ELR11599.1 - 0.058 13.5 1.2 0.091 12.8 1.2 1.2 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding ATG16 PF08614.11 ELR11599.1 - 0.087 13.0 4.6 0.15 12.3 4.6 1.3 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) DUF2252 PF10009.9 ELR11599.1 - 0.1 11.6 0.4 0.14 11.2 0.4 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2252) HAUS-augmin3 PF14932.6 ELR11599.1 - 0.14 11.7 1.2 0.25 10.9 1.2 1.3 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 3 M16C_assoc PF08367.11 ELR11599.1 - 0.17 11.0 1.3 0.25 10.4 1.3 1.2 1 0 0 1 1 1 0 Peptidase M16C associated SlyX PF04102.12 ELR11599.1 - 0.4 11.3 4.3 0.12 13.0 0.9 1.9 2 0 0 2 2 1 0 SlyX C2 PF00168.30 ELR11600.1 - 2.1e-15 56.8 0.0 4.9e-15 55.7 0.0 1.6 2 0 0 2 2 2 1 C2 domain Ank_5 PF13857.6 ELR11600.1 - 2.2e-07 31.0 1.8 0.0008 19.7 0.3 1.8 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 ELR11600.1 - 0.00029 21.3 0.1 0.00067 20.2 0.1 1.6 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 ELR11600.1 - 0.00099 19.6 0.0 0.0016 19.0 0.0 1.3 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.30 ELR11600.1 - 0.01 16.2 0.1 0.48 11.0 0.0 2.5 2 0 0 2 2 2 0 Ankyrin repeat Ank_3 PF13606.6 ELR11600.1 - 0.014 15.9 0.0 4.5 8.2 0.0 2.5 2 0 0 2 2 2 0 Ankyrin repeat COX5B PF01215.19 ELR11600.1 - 0.12 12.0 0.0 0.21 11.3 0.0 1.3 1 0 0 1 1 1 0 Cytochrome c oxidase subunit Vb AAA PF00004.29 ELR11601.1 - 9.3e-51 171.7 0.0 3.1e-28 98.8 0.0 3.2 2 1 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 ELR11601.1 - 9.6e-14 50.9 2.3 7.9e-11 41.6 0.1 2.5 2 0 0 2 2 2 2 AAA+ lid domain AAA_16 PF13191.6 ELR11601.1 - 1.1e-13 51.9 7.4 3.9e-05 24.1 3.0 5.2 2 2 1 3 3 3 2 AAA ATPase domain AAA_22 PF13401.6 ELR11601.1 - 1.3e-11 44.9 4.9 0.017 15.4 0.6 5.5 3 2 2 5 5 4 2 AAA domain IstB_IS21 PF01695.17 ELR11601.1 - 1.1e-08 35.0 0.0 0.00093 19.0 0.0 2.5 2 1 0 2 2 2 2 IstB-like ATP binding protein AAA_14 PF13173.6 ELR11601.1 - 7.1e-08 32.6 0.0 0.00058 19.9 0.0 2.5 2 0 0 2 2 2 2 AAA domain DUF815 PF05673.13 ELR11601.1 - 1.3e-07 31.1 0.0 0.0037 16.5 0.0 2.6 3 0 0 3 3 3 2 Protein of unknown function (DUF815) AAA_18 PF13238.6 ELR11601.1 - 7.5e-07 29.7 0.0 0.079 13.5 0.0 2.9 2 1 0 2 2 2 2 AAA domain AAA_25 PF13481.6 ELR11601.1 - 1.9e-06 27.6 0.7 0.2 11.2 0.0 3.5 2 1 1 3 3 3 2 AAA domain ATPase_2 PF01637.18 ELR11601.1 - 2.9e-06 27.4 0.1 1.6 8.5 0.0 4.0 3 1 1 4 4 4 2 ATPase domain predominantly from Archaea TIP49 PF06068.13 ELR11601.1 - 5.4e-06 25.9 0.1 0.0015 17.8 0.0 2.4 2 1 0 2 2 2 1 TIP49 P-loop domain RuvB_N PF05496.12 ELR11601.1 - 8e-06 25.7 0.0 0.0016 18.2 0.0 2.7 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_28 PF13521.6 ELR11601.1 - 1.4e-05 25.4 0.0 0.13 12.5 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_5 PF07728.14 ELR11601.1 - 3e-05 24.0 0.1 0.084 12.9 0.0 3.2 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) ATPase PF06745.13 ELR11601.1 - 3.2e-05 23.4 0.0 0.2 11.0 0.0 2.4 2 0 0 2 2 2 2 KaiC AAA_17 PF13207.6 ELR11601.1 - 6.3e-05 23.4 0.1 0.00022 21.7 0.0 2.0 2 0 0 2 2 1 1 AAA domain AAA_33 PF13671.6 ELR11601.1 - 0.00014 22.1 0.0 0.2 11.8 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_7 PF12775.7 ELR11601.1 - 0.00021 20.9 0.0 0.59 9.6 0.0 2.5 2 0 0 2 2 2 2 P-loop containing dynein motor region Vps4_C PF09336.10 ELR11601.1 - 0.00034 20.5 0.1 0.0072 16.3 0.0 2.7 2 0 0 2 2 2 1 Vps4 C terminal oligomerisation domain RNA_helicase PF00910.22 ELR11601.1 - 0.00036 20.9 0.0 0.49 10.8 0.0 2.6 2 0 0 2 2 2 1 RNA helicase NACHT PF05729.12 ELR11601.1 - 0.00066 19.6 1.5 1.4 8.8 0.0 3.8 3 1 1 4 4 4 1 NACHT domain TsaE PF02367.17 ELR11601.1 - 0.0012 18.8 0.0 1.5 8.9 0.0 2.4 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_30 PF13604.6 ELR11601.1 - 0.0012 18.6 0.0 3.2 7.4 0.0 3.0 3 0 0 3 3 3 2 AAA domain Bac_DnaA PF00308.18 ELR11601.1 - 0.0014 18.5 0.0 0.58 10.0 0.0 2.8 2 1 0 2 2 2 1 Bacterial dnaA protein AAA_24 PF13479.6 ELR11601.1 - 0.0016 18.2 0.1 0.31 10.7 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_29 PF13555.6 ELR11601.1 - 0.002 17.8 0.0 0.76 9.6 0.0 2.8 3 0 0 3 3 2 1 P-loop containing region of AAA domain PhoH PF02562.16 ELR11601.1 - 0.0026 17.3 0.0 1.6 8.1 0.0 2.4 2 0 0 2 2 2 1 PhoH-like protein NTPase_1 PF03266.15 ELR11601.1 - 0.0027 17.6 0.4 7.7 6.4 0.0 3.6 3 1 1 4 4 4 0 NTPase ABC_tran PF00005.27 ELR11601.1 - 0.0033 17.9 0.0 1.2 9.6 0.0 2.4 2 0 0 2 2 2 1 ABC transporter Mg_chelatase PF01078.21 ELR11601.1 - 0.0054 16.1 0.2 0.36 10.2 0.0 2.3 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI Zeta_toxin PF06414.12 ELR11601.1 - 0.0093 15.3 0.0 1.2 8.4 0.0 2.5 2 0 0 2 2 2 1 Zeta toxin Sigma54_activat PF00158.26 ELR11601.1 - 0.014 15.1 0.1 4.7 6.9 0.0 2.9 2 1 0 2 2 2 0 Sigma-54 interaction domain T2SSE PF00437.20 ELR11601.1 - 0.022 13.8 0.0 2 7.4 0.0 2.3 2 0 0 2 2 2 0 Type II/IV secretion system protein Viral_helicase1 PF01443.18 ELR11601.1 - 0.027 14.2 0.0 3.4 7.4 0.0 2.2 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase AAA_2 PF07724.14 ELR11601.1 - 0.032 14.3 0.0 1.6 8.8 0.0 2.6 2 1 0 2 2 2 0 AAA domain (Cdc48 subfamily) AAA_11 PF13086.6 ELR11601.1 - 0.032 14.0 0.0 1.2 8.9 0.0 2.2 2 0 0 2 2 2 0 AAA domain DAP3 PF10236.9 ELR11601.1 - 0.036 13.2 0.0 8.3 5.5 0.0 2.3 2 0 0 2 2 2 0 Mitochondrial ribosomal death-associated protein 3 AAA_19 PF13245.6 ELR11601.1 - 0.046 14.0 0.0 5.9 7.2 0.0 2.7 2 0 0 2 2 2 0 AAA domain DUF2075 PF09848.9 ELR11601.1 - 0.11 11.8 0.8 2.1 7.5 0.1 2.4 2 1 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) RNA12 PF10443.9 ELR11601.1 - 0.17 10.6 0.0 0.33 9.6 0.0 1.4 1 0 0 1 1 1 0 RNA12 protein ADK PF00406.22 ELR11601.1 - 0.21 11.7 0.0 0.37 10.9 0.0 1.4 1 0 0 1 1 1 0 Adenylate kinase Peptidase_M1 PF01433.20 ELR11602.1 - 1.4e-84 283.0 1.1 2.2e-84 282.4 1.1 1.3 1 0 0 1 1 1 1 Peptidase family M1 domain ERAP1_C PF11838.8 ELR11602.1 - 7e-67 226.2 1.9 1.3e-62 212.2 0.1 2.5 2 1 1 3 3 3 2 ERAP1-like C-terminal domain Peptidase_M1_N PF17900.1 ELR11602.1 - 1.4e-48 165.6 0.2 2e-48 165.1 0.2 1.3 1 0 0 1 1 1 1 Peptidase M1 N-terminal domain Aminopep PF10023.9 ELR11602.1 - 0.028 13.8 0.0 0.05 13.0 0.0 1.3 1 0 0 1 1 1 0 Putative aminopeptidase PNP_UDP_1 PF01048.20 ELR11603.1 - 2e-26 92.7 0.0 2.6e-26 92.4 0.0 1.2 1 0 0 1 1 1 1 Phosphorylase superfamily DUF1084 PF06454.11 ELR11604.1 - 4.4e-11 42.7 26.7 1.2e-07 31.4 10.1 2.2 2 0 0 2 2 2 2 Protein of unknown function (DUF1084) ETRAMP PF09716.10 ELR11604.1 - 3.7 7.7 6.2 15 5.8 6.2 2.0 1 1 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) VMA21 PF09446.10 ELR11605.1 - 4.4e-10 39.5 8.8 4.8e-10 39.4 8.8 1.0 1 0 0 1 1 1 1 VMA21-like domain Pox_P21 PF05313.12 ELR11605.1 - 0.14 11.8 3.0 0.15 11.6 3.0 1.1 1 0 0 1 1 1 0 Poxvirus P21 membrane protein Longin PF13774.6 ELR11606.1 - 2.8e-21 75.4 0.3 4.2e-21 74.8 0.3 1.3 1 0 0 1 1 1 1 Regulated-SNARE-like domain Synaptobrevin PF00957.21 ELR11606.1 - 9.2e-20 70.2 0.5 1.5e-19 69.6 0.5 1.4 1 0 0 1 1 1 1 Synaptobrevin Transgly_assoc PF04226.13 ELR11606.1 - 0.036 14.3 0.2 0.061 13.6 0.2 1.3 1 0 0 1 1 1 0 Transglycosylase associated protein NADase_NGA PF07461.11 ELR11606.1 - 0.044 12.7 0.3 0.055 12.4 0.3 1.1 1 0 0 1 1 1 0 Nicotine adenine dinucleotide glycohydrolase (NADase) RNase_PH PF01138.21 ELR11607.1 - 1e-20 74.6 0.0 1.5e-20 74.0 0.0 1.3 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 ELR11607.1 - 1.1e-11 44.6 0.1 2.8e-11 43.3 0.0 1.8 2 0 0 2 2 2 1 3' exoribonuclease family, domain 2 Med1 PF10744.9 ELR11608.1 - 5.7e-10 38.8 0.0 1.7e-08 33.9 0.0 2.5 1 1 1 2 2 2 2 Mediator of RNA polymerase II transcription subunit 1 Muted PF14942.6 ELR11608.1 - 0.2 12.0 0.5 1 9.7 0.1 2.0 2 0 0 2 2 2 0 Organelle biogenesis, Muted-like protein DUF4667 PF15700.5 ELR11610.1 - 0.1 12.6 5.9 0.21 11.7 0.9 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4667) Chorion_2 PF03964.15 ELR11610.1 - 2.8 8.8 13.4 0.26 12.1 2.5 2.9 2 0 0 2 2 2 0 Chorion family 2 GRP PF07172.11 ELR11610.1 - 3.3 8.5 13.5 3.6 8.4 4.7 2.7 2 0 0 2 2 2 0 Glycine rich protein family B-block_TFIIIC PF04182.12 ELR11611.1 - 2.3e-14 53.3 0.8 9.3e-14 51.4 0.2 2.3 3 0 0 3 3 3 1 B-block binding subunit of TFIIIC HTH_24 PF13412.6 ELR11611.1 - 0.00095 18.7 0.1 0.63 9.7 0.0 3.3 3 0 0 3 3 3 2 Winged helix-turn-helix DNA-binding MarR_2 PF12802.7 ELR11611.1 - 0.0021 17.9 0.2 0.14 12.1 0.1 3.0 3 0 0 3 3 3 1 MarR family CMD PF02627.20 ELR11611.1 - 0.072 13.2 0.0 0.18 11.9 0.0 1.6 1 0 0 1 1 1 0 Carboxymuconolactone decarboxylase family VWA_2 PF13519.6 ELR11612.1 - 4.1e-08 33.8 0.1 0.023 15.3 0.0 3.4 2 1 0 3 3 3 2 von Willebrand factor type A domain zf-Sec23_Sec24 PF04810.15 ELR11612.1 - 1.5e-05 24.9 0.0 3.2e-05 23.9 0.0 1.5 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger VWA_CoxE PF05762.14 ELR11612.1 - 0.0026 17.2 0.2 0.87 8.9 0.1 2.3 2 0 0 2 2 2 2 VWA domain containing CoxE-like protein CEND1 PF15677.5 ELR11612.1 - 0.0051 17.4 0.8 0.0092 16.5 0.8 1.4 1 0 0 1 1 1 1 Cell cycle exit and neuronal differentiation protein 1 VWA PF00092.28 ELR11612.1 - 0.011 16.0 0.1 4.9 7.4 0.0 3.1 3 0 0 3 3 3 0 von Willebrand factor type A domain Lar_restr_allev PF14354.6 ELR11612.1 - 0.88 10.0 4.0 1.8 9.0 0.9 2.7 1 1 1 2 2 2 0 Restriction alleviation protein Lar UBX PF00789.20 ELR11613.1 - 1.2e-11 44.7 0.0 2.9e-11 43.4 0.0 1.5 1 1 0 1 1 1 1 UBX domain Herpes_UL74 PF07982.12 ELR11613.1 - 0.4 9.6 3.0 0.54 9.2 3.0 1.1 1 0 0 1 1 1 0 Herpes UL74 glycoproteins FSA_C PF10479.9 ELR11613.1 - 1.2 7.1 5.5 1.6 6.8 5.5 1.1 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus CCDC53 PF10152.9 ELR11613.1 - 1.6 9.1 5.4 3.7 7.9 4.8 1.9 2 0 0 2 2 2 0 Subunit CCDC53 of WASH complex NUDE_C PF04880.13 ELR11613.1 - 1.7 9.1 13.1 0.25 11.8 9.3 1.5 2 0 0 2 2 2 0 NUDE protein, C-terminal conserved region FAM199X PF15814.5 ELR11613.1 - 1.7 7.6 5.1 2.8 6.9 5.1 1.4 1 0 0 1 1 1 0 Protein family FAM199X Draxin PF15550.6 ELR11613.1 - 2.4 7.9 6.9 3.6 7.4 6.9 1.2 1 0 0 1 1 1 0 Draxin Roughex PF06020.11 ELR11613.1 - 2.9 6.9 8.3 4.9 6.2 8.3 1.3 1 0 0 1 1 1 0 Drosophila roughex protein MAP65_ASE1 PF03999.12 ELR11613.1 - 3 6.5 8.5 3.4 6.2 8.5 1.1 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) Ndc1_Nup PF09531.10 ELR11613.1 - 7.5 5.1 6.4 9 4.8 6.4 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Spt20 PF12090.8 ELR11613.1 - 9.2 5.8 8.9 20 4.7 8.7 1.6 2 0 0 2 2 2 0 Spt20 family Thioredoxin_7 PF13899.6 ELR11614.1 - 0.00091 19.4 0.0 0.0018 18.4 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin-like DEC-1_N PF04625.13 ELR11614.1 - 1.4 7.8 8.4 0.6 9.1 6.0 1.4 1 1 0 1 1 1 0 DEC-1 protein, N-terminal region Abhydrolase_3 PF07859.13 ELR11615.1 - 1.5e-14 54.4 3.9 1.5e-13 51.1 3.9 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold COesterase PF00135.28 ELR11615.1 - 1.4e-07 30.8 0.1 5.5e-07 28.8 0.1 1.7 1 1 0 1 1 1 1 Carboxylesterase family Peptidase_S9 PF00326.21 ELR11615.1 - 6.3e-07 29.1 0.0 1.5e-05 24.5 0.0 2.2 2 0 0 2 2 2 1 Prolyl oligopeptidase family Hydrolase_4 PF12146.8 ELR11615.1 - 0.0011 18.3 0.0 1.3 8.3 0.0 2.3 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Lipase_3 PF01764.25 ELR11615.1 - 0.013 15.3 0.0 0.024 14.5 0.0 1.4 1 0 0 1 1 1 0 Lipase (class 3) PPK2 PF03976.14 ELR11615.1 - 0.11 11.9 0.0 0.17 11.4 0.0 1.2 1 0 0 1 1 1 0 Polyphosphate kinase 2 (PPK2) NPCC PF08058.11 ELR11616.1 - 0.13 12.3 0.0 0.21 11.7 0.0 1.4 1 0 0 1 1 1 0 Nuclear pore complex component CytochromB561_N PF09786.9 ELR11617.1 - 2.4e-49 168.8 0.0 3.1e-49 168.5 0.0 1.1 1 0 0 1 1 1 1 Cytochrome B561, N terminal PH PF00169.29 ELR11618.1 - 2.8e-08 34.2 0.0 5.7e-08 33.2 0.0 1.5 1 0 0 1 1 1 1 PH domain zf-RING_14 PF17978.1 ELR11618.1 - 0.0027 18.1 0.2 0.0054 17.1 0.2 1.4 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain zf-RING_5 PF14634.6 ELR11618.1 - 0.0052 16.7 2.3 0.0052 16.7 2.3 2.9 2 1 0 2 2 2 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 ELR11618.1 - 0.042 13.9 0.7 0.042 13.9 0.7 2.3 2 0 0 2 2 2 0 RING-type zinc-finger 14-3-3 PF00244.20 ELR11621.1 - 6e-17 61.9 0.5 7e-17 61.7 0.5 1.0 1 0 0 1 1 1 1 14-3-3 protein CstA PF02554.14 ELR11622.1 - 0.015 14.3 0.7 0.015 14.3 0.7 1.0 1 0 0 1 1 1 0 Carbon starvation protein CstA WHIM1 PF15612.6 ELR11622.1 - 0.038 13.6 0.3 0.055 13.0 0.3 1.3 1 0 0 1 1 1 0 WSTF, HB1, Itc1p, MBD9 motif 1 GSG-1 PF07803.11 ELR11622.1 - 0.066 13.1 0.3 0.075 13.0 0.3 1.2 1 0 0 1 1 1 0 GSG1-like protein ECH_1 PF00378.20 ELR11624.1 - 5.7e-23 81.5 0.0 1.5e-21 76.9 0.0 2.1 1 1 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 ELR11624.1 - 4.8e-13 49.3 0.0 5.6e-12 45.8 0.0 2.3 2 1 0 2 2 2 1 Enoyl-CoA hydratase/isomerase ADSL_C PF10397.9 ELR11624.1 - 0.12 13.0 0.7 0.21 12.2 0.1 1.7 2 0 0 2 2 2 0 Adenylosuccinate lyase C-terminus TPR_2 PF07719.17 ELR11625.1 - 1.1e-10 40.8 17.6 0.029 14.5 0.0 8.7 8 0 0 8 8 8 3 Tetratricopeptide repeat TPR_19 PF14559.6 ELR11625.1 - 8.3e-07 29.4 3.7 0.57 10.7 0.0 5.6 4 1 0 5 5 4 2 Tetratricopeptide repeat TPR_8 PF13181.6 ELR11625.1 - 5.6e-06 26.2 6.3 5.8 7.4 0.1 6.4 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_1 PF00515.28 ELR11625.1 - 8.6e-06 25.4 11.4 0.17 11.8 0.7 6.6 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_17 PF13431.6 ELR11625.1 - 0.0036 17.6 5.6 41 4.9 0.0 6.7 7 0 0 7 7 7 0 Tetratricopeptide repeat TPR_16 PF13432.6 ELR11625.1 - 0.0096 16.6 0.7 0.0096 16.6 0.7 8.1 9 1 1 10 10 8 2 Tetratricopeptide repeat TPR_14 PF13428.6 ELR11625.1 - 0.031 15.1 30.9 3.9 8.5 0.0 9.4 10 1 2 12 12 6 0 Tetratricopeptide repeat TPR_11 PF13414.6 ELR11625.1 - 0.16 11.6 5.9 0.67 9.7 0.1 4.1 5 0 0 5 5 5 0 TPR repeat TPR_12 PF13424.6 ELR11625.1 - 0.36 11.2 15.8 0.11 12.8 2.0 6.0 5 1 0 5 5 5 0 Tetratricopeptide repeat TPR_7 PF13176.6 ELR11625.1 - 0.53 10.4 8.1 12 6.3 0.1 5.2 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_9 PF13371.6 ELR11625.1 - 2 8.6 7.0 2.2 8.5 0.3 4.1 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_10 PF13374.6 ELR11625.1 - 3.3 7.7 12.7 11 6.0 0.5 5.2 5 0 0 5 5 5 0 Tetratricopeptide repeat DNA_pol_phi PF04931.13 ELR11625.1 - 3.8 5.5 15.9 7.2 4.6 15.9 1.4 1 0 0 1 1 1 0 DNA polymerase phi MIT PF04212.18 ELR11625.1 - 4.4 7.4 6.5 12 6.0 0.5 3.8 3 0 0 3 3 3 0 MIT (microtubule interacting and transport) domain TPR_6 PF13174.6 ELR11625.1 - 8.3 7.3 13.8 6 7.7 0.0 6.7 8 0 0 8 8 6 0 Tetratricopeptide repeat TPR_4 PF07721.14 ELR11625.1 - 9.5 7.2 17.2 1.3 9.8 0.1 6.0 4 0 0 4 4 4 0 Tetratricopeptide repeat HR_lesion PF05514.11 ELR11626.1 - 1.6e-07 31.6 1.0 3.9e-07 30.3 1.0 1.6 1 1 0 1 1 1 1 HR-like lesion-inducing SURF4 PF02077.15 ELR11626.1 - 0.0017 18.0 1.5 0.0028 17.3 0.2 1.8 1 1 0 2 2 2 1 SURF4 family MTABC_N PF16185.5 ELR11626.1 - 0.015 14.8 0.9 0.031 13.8 0.9 1.5 1 1 0 1 1 1 0 Mitochondrial ABC-transporter N-terminal five TM region DoxX PF07681.12 ELR11626.1 - 0.65 10.6 13.5 0.079 13.6 9.4 1.5 2 0 0 2 2 2 0 DoxX AhpC-TSA PF00578.21 ELR11627.1 - 3.6e-36 123.8 0.0 5.2e-36 123.3 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 ELR11627.1 - 1e-15 57.7 0.0 1.5e-15 57.2 0.0 1.2 1 0 0 1 1 1 1 Redoxin 1-cysPrx_C PF10417.9 ELR11627.1 - 4.1e-12 45.7 0.0 7.7e-12 44.9 0.0 1.5 1 0 0 1 1 1 1 C-terminal domain of 1-Cys peroxiredoxin SCO1-SenC PF02630.14 ELR11627.1 - 0.026 14.5 0.0 0.066 13.1 0.0 1.6 2 0 0 2 2 2 0 SCO1/SenC BCAS3 PF12490.8 ELR11627.1 - 0.13 11.7 0.0 0.17 11.4 0.0 1.1 1 0 0 1 1 1 0 Breast carcinoma amplified sequence 3 CAMSAP_CKK PF08683.11 ELR11627.1 - 0.15 12.2 0.0 0.84 9.8 0.0 1.9 2 0 0 2 2 2 0 Microtubule-binding calmodulin-regulated spectrin-associated FYRC PF05965.14 ELR11629.1 - 2.1e-17 63.0 0.0 6.2e-17 61.5 0.0 1.8 1 0 0 1 1 1 1 F/Y rich C-terminus FYRN PF05964.14 ELR11629.1 - 1.6e-15 56.7 0.0 2.4e-15 56.1 0.0 1.3 1 0 0 1 1 1 1 F/Y-rich N-terminus ECM1 PF05782.11 ELR11629.1 - 0.1 11.5 8.3 0.12 11.2 8.3 1.0 1 0 0 1 1 1 0 Extracellular matrix protein 1 (ECM1) DUF4746 PF15928.5 ELR11629.1 - 6.8 6.0 14.2 9.3 5.6 14.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Efg1 PF10153.9 ELR11629.1 - 7.9 6.9 12.3 12 6.3 12.3 1.3 1 0 0 1 1 1 0 rRNA-processing protein Efg1 CCDC-167 PF15188.6 ELR11629.1 - 9.8 6.6 12.1 21 5.5 12.1 1.7 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 167 SNF2_N PF00176.23 ELR11630.1 - 9.6e-62 208.7 0.2 1.5e-61 208.1 0.2 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Bromodomain PF00439.25 ELR11630.1 - 2.7e-20 72.2 0.0 8.5e-20 70.6 0.0 1.9 1 0 0 1 1 1 1 Bromodomain Chromo PF00385.24 ELR11630.1 - 1.2e-18 66.8 10.8 1.6e-11 43.9 0.0 3.7 2 1 0 2 2 2 2 Chromo (CHRromatin Organisation MOdifier) domain Helicase_C PF00271.31 ELR11630.1 - 2.4e-17 63.3 0.0 7.6e-17 61.7 0.0 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 ELR11630.1 - 1.8e-09 37.8 0.0 4.2e-09 36.7 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit HDA2-3 PF11496.8 ELR11630.1 - 4.5e-07 29.3 0.0 1.4e-06 27.7 0.0 1.7 1 1 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 DEAD PF00270.29 ELR11630.1 - 0.0066 16.2 0.0 0.013 15.3 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 ELR11630.1 - 0.018 15.3 0.0 0.073 13.3 0.0 2.1 1 0 0 1 1 1 0 AAA domain SNF2_N PF00176.23 ELR11631.1 - 4.2e-71 239.5 1.6 8.8e-71 238.4 1.6 1.5 1 0 0 1 1 1 1 SNF2 family N-terminal domain HSA PF07529.13 ELR11631.1 - 3.4e-18 65.7 8.5 3.4e-18 65.7 8.5 5.1 5 1 1 6 6 4 1 HSA Helicase_C PF00271.31 ELR11631.1 - 3.4e-15 56.4 0.0 1.3e-14 54.5 0.0 2.1 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 ELR11631.1 - 1.7e-09 37.9 0.0 5e-09 36.4 0.0 1.9 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Myb_DNA-binding PF00249.31 ELR11631.1 - 5.4e-06 26.5 0.8 0.00023 21.3 0.0 3.2 3 0 0 3 3 3 1 Myb-like DNA-binding domain TPR_14 PF13428.6 ELR11631.1 - 7.3e-06 26.4 7.8 0.00028 21.4 0.4 4.7 2 1 1 3 3 3 2 Tetratricopeptide repeat DEAD PF00270.29 ELR11631.1 - 2.1e-05 24.3 0.0 0.00031 20.6 0.0 2.4 2 0 0 2 2 2 1 DEAD/DEAH box helicase TPR_19 PF14559.6 ELR11631.1 - 0.00068 20.1 0.2 0.0027 18.2 0.2 2.1 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_16 PF13432.6 ELR11631.1 - 0.0016 19.1 1.5 0.0016 19.1 1.5 4.1 3 1 0 3 3 2 1 Tetratricopeptide repeat TPR_6 PF13174.6 ELR11631.1 - 0.024 15.2 0.0 0.14 12.9 0.0 2.5 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_2 PF07719.17 ELR11631.1 - 0.051 13.7 0.1 2.5 8.4 0.0 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat DBINO PF13892.6 ELR11631.1 - 0.3 11.5 19.2 0.022 15.1 11.0 3.5 2 0 0 2 2 2 0 DNA-binding domain PALP PF00291.25 ELR11632.1 - 8.5e-51 173.1 0.1 1.1e-50 172.8 0.1 1.1 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme CBS PF00571.28 ELR11632.1 - 8e-12 45.4 0.0 3.6e-06 27.3 0.0 3.2 3 0 0 3 3 3 2 CBS domain HEAT PF02985.22 ELR11634.1 - 2e-09 36.9 30.4 0.011 15.9 0.4 8.8 9 0 0 9 9 9 3 HEAT repeat HEAT_2 PF13646.6 ELR11634.1 - 5.4e-09 36.3 21.3 7e-05 23.1 1.6 6.1 5 1 0 5 5 5 2 HEAT repeats HEAT_EZ PF13513.6 ELR11634.1 - 3.9e-08 33.6 33.2 0.014 15.9 1.9 8.5 6 2 2 8 8 8 4 HEAT-like repeat DUF4042 PF13251.6 ELR11634.1 - 1.9e-07 31.0 0.9 8.3e-06 25.6 0.0 3.6 4 0 0 4 4 4 1 Domain of unknown function (DUF4042) Velvet PF11754.8 ELR11634.1 - 0.0073 16.3 7.1 0.19 11.6 3.9 2.7 2 0 0 2 2 2 1 Velvet factor TFIIA PF03153.13 ELR11634.1 - 0.032 14.2 29.5 0.094 12.7 18.5 2.5 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Cnd1 PF12717.7 ELR11634.1 - 0.16 12.0 0.0 42 4.1 0.0 2.9 2 1 1 3 3 3 0 non-SMC mitotic condensation complex subunit 1 DUF3535 PF12054.8 ELR11634.1 - 3.6 6.7 15.8 0.34 10.1 0.2 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF3535) Neur_chan_memb PF02932.16 ELR11634.1 - 4.7 7.2 12.4 1.5 8.8 4.8 2.4 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region PAT1 PF09770.9 ELR11634.1 - 8.7 4.5 27.4 0.69 8.1 17.2 2.1 2 0 0 2 2 2 0 Topoisomerase II-associated protein PAT1 MFS_1 PF07690.16 ELR11635.1 - 5.8e-07 28.8 19.4 5.8e-07 28.8 19.4 2.5 1 1 1 2 2 2 1 Major Facilitator Superfamily Pex16 PF08610.10 ELR11636.1 - 1.2e-61 208.7 0.0 1.6e-61 208.3 0.0 1.2 1 0 0 1 1 1 1 Peroxisomal membrane protein (Pex16) DUF2567 PF10821.8 ELR11636.1 - 0.0018 18.4 1.1 0.0084 16.2 0.4 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF2567) SNARE PF05739.19 ELR11637.1 - 0.00046 20.1 0.0 0.00098 19.1 0.0 1.5 1 0 0 1 1 1 1 SNARE domain APG17 PF04108.12 ELR11637.1 - 0.0054 15.9 0.5 0.0065 15.6 0.5 1.1 1 0 0 1 1 1 1 Autophagy protein Apg17 MAGSP PF03082.14 ELR11637.1 - 0.0083 15.8 0.1 0.01 15.5 0.1 1.1 1 0 0 1 1 1 1 Male accessory gland secretory protein Use1 PF09753.9 ELR11637.1 - 0.04 13.7 0.0 0.04 13.7 0.0 1.1 1 0 0 1 1 1 0 Membrane fusion protein Use1 DUF745 PF05335.13 ELR11637.1 - 0.063 13.0 0.5 0.078 12.7 0.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF745) Med2 PF11214.8 ELR11637.1 - 0.077 13.2 0.1 0.11 12.7 0.1 1.3 1 0 0 1 1 1 0 Mediator complex subunit 2 DUF948 PF06103.11 ELR11637.1 - 0.16 12.3 0.4 0.4 11.0 0.4 1.7 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF948) DUF1899 PF08953.11 ELR11638.1 - 2e-30 104.5 0.2 3.2e-30 103.8 0.2 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1899) WD40 PF00400.32 ELR11638.1 - 2e-20 72.7 3.0 7.2e-05 23.5 0.2 4.4 4 0 0 4 4 4 3 WD domain, G-beta repeat WD40_4 PF16300.5 ELR11638.1 - 5.1e-19 67.9 0.6 9.2e-19 67.1 0.6 1.5 1 0 0 1 1 1 1 Type of WD40 repeat ANAPC4_WD40 PF12894.7 ELR11638.1 - 1.3e-09 38.2 0.1 3.6e-05 24.0 0.0 3.1 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ELR11638.1 - 0.017 13.8 0.1 2 6.9 0.2 2.5 1 1 2 3 3 3 0 Nucleoporin Nup120/160 PQQ_2 PF13360.6 ELR11638.1 - 0.032 13.8 0.2 0.075 12.6 0.2 1.6 1 1 0 1 1 1 0 PQQ-like domain Disaggr_repeat PF06848.11 ELR11638.1 - 0.048 13.3 0.1 0.11 12.1 0.1 1.6 1 0 0 1 1 1 0 Disaggregatase related repeat DUF525 PF04379.14 ELR11639.1 - 2.7e-29 101.2 0.2 9.4e-28 96.3 0.0 2.6 3 0 0 3 3 3 1 ApaG domain F-box-like PF12937.7 ELR11639.1 - 7.5e-08 32.1 2.8 1.4e-07 31.3 2.8 1.5 1 0 0 1 1 1 1 F-box-like SMI1_KNR4 PF09346.10 ELR11639.1 - 1e-07 32.4 0.0 2e-07 31.5 0.0 1.5 1 0 0 1 1 1 1 SMI1 / KNR4 family (SUKH-1) F-box PF00646.33 ELR11639.1 - 0.0055 16.6 0.0 0.01 15.7 0.0 1.5 1 0 0 1 1 1 1 F-box domain MMgT PF10270.9 ELR11640.1 - 1.8e-14 53.9 0.1 2.3e-14 53.5 0.1 1.2 1 0 0 1 1 1 1 Membrane magnesium transporter Cation_efflux PF01545.21 ELR11641.1 - 1.9e-25 89.8 7.3 2.2e-23 83.1 7.3 2.1 1 1 0 1 1 1 1 Cation efflux family WD40 PF00400.32 ELR11641.1 - 2.8e-10 40.6 3.9 4.9e-05 24.0 0.1 3.4 2 0 0 2 2 2 2 WD domain, G-beta repeat Zip PF02535.22 ELR11641.1 - 0.0011 18.3 31.0 0.0022 17.3 10.8 3.1 2 1 0 3 3 3 2 ZIP Zinc transporter RAMP4 PF06624.12 ELR11641.1 - 0.22 11.6 0.1 0.22 11.6 0.1 2.7 2 1 0 2 2 2 0 Ribosome associated membrane protein RAMP4 WD40 PF00400.32 ELR11642.1 - 3.5e-17 62.5 7.9 1.1e-05 26.1 0.1 4.8 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ELR11642.1 - 2.2e-06 27.9 1.2 0.00051 20.3 0.0 3.0 2 1 1 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain Metallophos_2 PF12850.7 ELR11643.1 - 2.4e-19 70.1 0.0 4.8e-19 69.1 0.0 1.5 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Methyltransf_25 PF13649.6 ELR11643.1 - 1.1e-15 58.1 0.0 1.5e-14 54.5 0.0 2.6 3 0 0 3 3 3 1 Methyltransferase domain Methyltransf_12 PF08242.12 ELR11643.1 - 6.1e-14 52.6 0.0 2.8e-13 50.5 0.0 2.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 ELR11643.1 - 1e-13 51.5 0.0 1.8e-13 50.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ELR11643.1 - 3.6e-13 50.0 0.0 1e-12 48.5 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ELR11643.1 - 3.3e-09 36.7 0.0 5.9e-09 35.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Metallophos PF00149.28 ELR11643.1 - 0.00014 22.4 0.5 0.37 11.3 0.0 3.1 2 1 1 3 3 3 2 Calcineurin-like phosphoesterase MTS PF05175.14 ELR11643.1 - 0.00049 19.7 0.0 0.0015 18.1 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_2 PF00891.18 ELR11643.1 - 0.018 14.4 0.0 0.034 13.5 0.0 1.3 1 0 0 1 1 1 0 O-methyltransferase domain Ubie_methyltran PF01209.18 ELR11643.1 - 0.02 14.3 0.0 0.034 13.5 0.0 1.3 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family Hexapep PF00132.24 ELR11644.1 - 2.6e-16 58.6 16.4 3.1e-06 26.7 0.8 4.5 3 1 1 4 4 4 4 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 ELR11644.1 - 1.5e-08 34.2 12.4 4.6e-05 23.1 1.1 4.4 2 1 2 4 4 4 4 Hexapeptide repeat of succinyl-transferase DUF4954 PF16314.5 ELR11644.1 - 0.13 10.3 0.3 0.18 9.9 0.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4954) FmiP_Thoc5 PF09766.9 ELR11645.1 - 1.3e-66 225.3 0.4 3.1e-66 224.1 0.4 1.6 1 1 0 1 1 1 1 Fms-interacting protein/Thoc5 TSKS PF15358.6 ELR11645.1 - 0.12 10.7 3.6 0.17 10.3 3.6 1.1 1 0 0 1 1 1 0 Testis-specific serine kinase substrate RasGAP PF00616.19 ELR11646.1 - 1.4e-33 116.4 0.0 3.3e-20 72.7 0.0 2.6 1 1 1 2 2 2 2 GTPase-activator protein for Ras-like GTPase CRAL_TRIO_2 PF13716.6 ELR11646.1 - 1.6e-14 54.3 0.0 6e-14 52.4 0.0 2.1 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain MOR2-PAG1_C PF14225.6 ELR11646.1 - 2e-08 34.5 0.0 2e-08 34.5 0.0 3.4 3 0 0 3 3 3 1 Cell morphogenesis C-terminal CRAL_TRIO PF00650.20 ELR11646.1 - 0.0017 18.1 0.1 0.009 15.7 0.1 2.3 1 0 0 1 1 1 1 CRAL/TRIO domain NAPRTase PF04095.16 ELR11647.1 - 6.1e-38 130.8 0.0 1.2e-37 129.8 0.0 1.5 2 0 0 2 2 2 1 Nicotinate phosphoribosyltransferase (NAPRTase) family DUF5598 PF18127.1 ELR11647.1 - 1.9e-11 44.3 0.1 5e-11 42.9 0.1 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF5598) DUF3813 PF12758.7 ELR11647.1 - 0.15 12.4 0.1 0.37 11.1 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3813) F_actin_bund_C PF18060.1 ELR11648.1 - 4.2e-19 68.4 2.8 7.8e-19 67.6 2.8 1.4 1 0 0 1 1 1 1 F actin bundling C terminal Dockerin_1 PF00404.18 ELR11648.1 - 0.19 11.9 0.0 0.47 10.7 0.0 1.6 1 0 0 1 1 1 0 Dockerin type I domain FA_desaturase PF00487.24 ELR11649.1 - 4.1e-30 105.4 36.6 4.1e-30 105.4 36.6 1.8 2 0 0 2 2 2 1 Fatty acid desaturase Cyt-b5 PF00173.28 ELR11649.1 - 6.1e-20 71.2 0.0 1.1e-19 70.3 0.0 1.5 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain TH1 PF04858.13 ELR11650.1 - 1.7e-144 482.7 0.1 2.1e-144 482.3 0.1 1.1 1 0 0 1 1 1 1 TH1 protein DUF4667 PF15700.5 ELR11650.1 - 0.004 17.3 2.7 0.0066 16.6 2.7 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4667) IMUP PF15761.5 ELR11650.1 - 0.34 11.6 10.3 0.62 10.8 10.3 1.3 1 0 0 1 1 1 0 Immortalisation up-regulated protein SR-25 PF10500.9 ELR11650.1 - 1.1 8.8 16.6 1.9 8.1 16.6 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein DUF508 PF04370.12 ELR11650.1 - 2.7 7.7 9.6 7 6.4 9.6 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF508) RAP1 PF07218.11 ELR11650.1 - 2.9 6.1 6.9 4.1 5.6 6.9 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) RhoGEF PF00621.20 ELR11651.1 - 3.5e-34 118.6 0.0 6e-34 117.9 0.0 1.4 1 0 0 1 1 1 1 RhoGEF domain PH PF00169.29 ELR11651.1 - 9.6e-09 35.7 0.0 2.3e-08 34.5 0.0 1.7 1 0 0 1 1 1 1 PH domain PH_16 PF17838.1 ELR11651.1 - 0.0053 16.6 0.0 0.0096 15.8 0.0 1.4 1 0 0 1 1 1 1 PH domain PH_13 PF16652.5 ELR11651.1 - 0.0055 16.5 0.1 0.015 15.1 0.1 1.8 1 1 0 1 1 1 1 Pleckstrin homology domain TFIIA PF03153.13 ELR11651.1 - 9.6 6.1 10.9 15 5.4 10.9 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Pkinase PF00069.25 ELR11652.1 - 1.2e-67 228.1 0.0 1.6e-67 227.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain DEP PF00610.21 ELR11652.1 - 1.6e-48 162.7 0.0 4.4e-23 81.1 0.1 2.6 2 0 0 2 2 2 2 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) Pkinase_Tyr PF07714.17 ELR11652.1 - 1.5e-32 112.9 0.0 2e-32 112.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ELR11652.1 - 3.4e-06 26.6 0.0 6.1e-06 25.8 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Pkinase_C PF00433.24 ELR11652.1 - 6.9e-05 23.5 0.7 6.9e-05 23.5 0.7 2.4 3 0 0 3 3 3 1 Protein kinase C terminal domain APH PF01636.23 ELR11652.1 - 0.023 14.6 0.0 0.053 13.4 0.0 1.6 1 0 0 1 1 1 0 Phosphotransferase enzyme family Hemerythrin PF01814.23 ELR11653.1 - 5e-14 53.0 7.4 8.6e-14 52.3 7.4 1.4 1 0 0 1 1 1 1 Hemerythrin HHE cation binding domain zf-NOSIP PF15906.5 ELR11654.1 - 4.3e-16 58.8 0.0 8.4e-16 57.9 0.0 1.5 1 0 0 1 1 1 1 Zinc-finger of nitric oxide synthase-interacting protein Rtf2 PF04641.12 ELR11654.1 - 1.4e-07 31.1 9.5 0.0006 19.2 0.0 3.0 2 1 1 3 3 3 2 Rtf2 RING-finger U-box PF04564.15 ELR11654.1 - 0.0039 17.3 0.8 0.22 11.7 0.0 3.7 3 1 1 4 4 4 1 U-box domain BRF1 PF07741.13 ELR11654.1 - 0.039 14.3 10.0 0.081 13.3 10.0 1.5 1 0 0 1 1 1 0 Brf1-like TBP-binding domain Elf1 PF05129.13 ELR11654.1 - 0.075 13.1 0.4 0.3 11.2 0.2 2.1 2 0 0 2 2 2 0 Transcription elongation factor Elf1 like COX14 PF14880.6 ELR11654.1 - 0.5 10.2 4.3 4.8 7.1 0.4 2.6 2 0 0 2 2 2 0 Cytochrome oxidase c assembly DUF3987 PF13148.6 ELR11654.1 - 0.89 8.5 8.5 0.95 8.4 7.7 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3987) Ras PF00071.22 ELR11655.1 - 5.1e-50 169.2 0.0 6.3e-50 168.9 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR11655.1 - 8.4e-31 106.7 0.0 2.4e-30 105.2 0.0 1.7 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR11655.1 - 1.6e-10 40.7 0.0 2e-10 40.4 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 ELR11655.1 - 0.00017 21.6 0.0 0.00035 20.6 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase RNA_helicase PF00910.22 ELR11655.1 - 0.00029 21.2 0.2 0.0035 17.7 0.2 2.2 1 1 0 1 1 1 1 RNA helicase Gtr1_RagA PF04670.12 ELR11655.1 - 0.00031 20.2 0.0 0.00041 19.8 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 ELR11655.1 - 0.0072 16.2 0.2 1.4 8.8 0.0 2.2 2 0 0 2 2 2 1 RsgA GTPase GTP_EFTU PF00009.27 ELR11655.1 - 0.0087 15.6 0.3 0.028 14.0 0.0 1.9 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain ArgoMid PF16487.5 ELR11655.1 - 0.017 15.4 0.0 0.046 14.0 0.0 1.7 1 1 0 1 1 1 0 Mid domain of argonaute G-alpha PF00503.20 ELR11655.1 - 0.019 14.1 2.5 2.2 7.4 0.1 2.6 2 1 1 3 3 3 0 G-protein alpha subunit Septin PF00735.18 ELR11655.1 - 0.069 12.4 0.1 0.15 11.3 0.0 1.6 2 0 0 2 2 2 0 Septin AAA_16 PF13191.6 ELR11655.1 - 0.071 13.5 0.0 0.11 12.8 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain AAA_7 PF12775.7 ELR11655.1 - 0.078 12.5 0.0 0.14 11.7 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region ATP_bind_1 PF03029.17 ELR11655.1 - 0.084 12.6 0.6 11 5.8 0.0 2.2 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein Pox_A32 PF04665.12 ELR11655.1 - 0.095 12.1 0.1 0.17 11.3 0.1 1.3 1 0 0 1 1 1 0 Poxvirus A32 protein TsaE PF02367.17 ELR11655.1 - 0.11 12.5 0.1 0.35 10.9 0.1 1.7 2 0 0 2 2 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE NTPase_1 PF03266.15 ELR11655.1 - 0.12 12.2 0.1 0.22 11.4 0.1 1.4 1 0 0 1 1 1 0 NTPase AAA_33 PF13671.6 ELR11655.1 - 0.14 12.4 0.2 0.31 11.2 0.2 1.6 1 0 0 1 1 1 0 AAA domain DUF829 PF05705.14 ELR11657.1 - 1.3e-51 175.9 0.0 1.5e-51 175.6 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF829) Cytochrom_B561 PF03188.16 ELR11658.1 - 9.4e-05 22.6 1.3 0.00056 20.1 1.1 2.3 2 1 0 2 2 2 1 Eukaryotic cytochrome b561 DUF2371 PF10177.9 ELR11658.1 - 0.7 10.1 5.6 0.43 10.7 0.7 2.7 2 1 0 2 2 2 0 Uncharacterised conserved protein (DUF2371) EMP24_GP25L PF01105.24 ELR11658.1 - 0.77 9.7 0.0 0.77 9.7 0.0 1.9 2 0 0 2 2 2 0 emp24/gp25L/p24 family/GOLD DUF3040 PF11239.8 ELR11658.1 - 0.79 10.0 9.3 2.3 8.6 0.0 4.2 4 2 0 4 4 4 0 Protein of unknown function (DUF3040) DUF2427 PF10348.9 ELR11658.1 - 3.5 7.5 7.5 0.19 11.5 0.3 2.3 3 0 0 3 3 3 0 Domain of unknown function (DUF2427) DUF2157 PF09925.9 ELR11658.1 - 9.1 6.1 9.5 1.4e+02 2.2 0.0 2.9 2 1 1 3 3 3 0 Predicted membrane protein (DUF2157) FKBP_C PF00254.28 ELR11659.1 - 3.4e-29 101.0 0.0 4.5e-29 100.6 0.0 1.2 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase zf-MYND PF01753.18 ELR11659.1 - 2.2e-11 43.6 15.6 3.3e-11 43.1 15.6 1.3 1 0 0 1 1 1 1 MYND finger HGTP_anticodon PF03129.20 ELR11659.1 - 0.067 13.3 0.0 0.13 12.5 0.0 1.5 1 0 0 1 1 1 0 Anticodon binding domain zf-Mss51 PF13824.6 ELR11659.1 - 0.22 11.7 7.6 0.38 10.9 7.6 1.4 1 0 0 1 1 1 0 Zinc-finger of mitochondrial splicing suppressor 51 Prok-RING_2 PF14445.6 ELR11659.1 - 0.28 11.4 5.1 0.44 10.7 5.1 1.3 1 0 0 1 1 1 0 Prokaryotic RING finger family 2 Mito_carr PF00153.27 ELR11660.1 - 6.1e-50 167.1 0.1 8.3e-23 80.1 0.0 3.2 2 1 1 3 3 3 3 Mitochondrial carrier protein RCC1 PF00415.18 ELR11661.1 - 2.6e-32 111.2 21.1 1.9e-08 34.8 0.1 8.1 7 1 0 7 7 7 7 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 ELR11661.1 - 2.5e-31 106.8 31.2 2.5e-09 36.7 0.4 7.2 7 0 0 7 7 7 6 Regulator of chromosome condensation (RCC1) repeat LRR_4 PF12799.7 ELR11662.1 - 0.00019 21.7 0.5 42 4.8 0.0 5.8 4 1 3 7 7 7 2 Leucine Rich repeats (2 copies) Proteasome PF00227.26 ELR11663.1 - 5e-46 156.6 0.1 7.2e-46 156.1 0.1 1.2 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 ELR11663.1 - 1.9e-15 56.2 0.1 3.6e-15 55.3 0.1 1.5 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature MmoB_DmpM PF02406.17 ELR11663.1 - 0.048 13.9 0.0 0.16 12.2 0.0 1.8 2 0 0 2 2 2 0 MmoB/DmpM family Apolipoprotein PF01442.18 ELR11664.1 - 0.026 14.4 103.4 0.012 15.5 15.6 5.7 1 1 5 6 6 6 0 Apolipoprotein A1/A4/E domain DUF883 PF05957.13 ELR11664.1 - 4.2 8.0 119.9 0.91 10.2 13.6 10.2 2 2 10 12 12 12 0 Bacterial protein of unknown function (DUF883) ApoLp-III PF07464.11 ELR11664.1 - 4.9 7.2 63.2 0.34 11.0 0.2 6.0 2 1 5 7 7 7 0 Apolipophorin-III precursor (apoLp-III) TIG_2 PF18020.1 ELR11665.1 - 0.03 14.9 0.3 54 4.5 0.0 3.4 3 0 0 3 3 3 0 TIG domain found in plexin Beta_helix PF13229.6 ELR11666.1 - 2.8e-29 102.0 34.4 4.4e-08 33.1 4.0 6.2 1 1 3 5 5 5 5 Right handed beta helix region NosD PF05048.13 ELR11666.1 - 3.5e-20 72.3 24.7 3.8e-08 32.9 1.6 5.8 1 1 3 4 4 4 4 Periplasmic copper-binding protein (NosD) sCache_3_2 PF17203.4 ELR11666.1 - 0.054 13.6 0.0 0.098 12.8 0.0 1.4 1 0 0 1 1 1 0 Single cache domain 3 Ank_4 PF13637.6 ELR11667.1 - 6.6e-55 182.8 16.7 3.2e-07 30.8 0.0 11.0 5 4 6 11 11 11 10 Ankyrin repeats (many copies) Ank_2 PF12796.7 ELR11667.1 - 3.1e-51 171.9 15.2 5.9e-12 46.0 0.4 7.7 2 2 4 7 7 7 7 Ankyrin repeats (3 copies) Ank_5 PF13857.6 ELR11667.1 - 1.6e-40 136.7 29.3 2.2e-08 34.2 0.1 11.0 6 4 6 12 12 12 9 Ankyrin repeats (many copies) Ank_3 PF13606.6 ELR11667.1 - 3.7e-40 131.3 18.2 4e-05 23.7 0.0 13.8 14 1 0 14 14 14 10 Ankyrin repeat Ank PF00023.30 ELR11667.1 - 1.2e-38 129.9 29.4 6e-07 29.6 0.0 12.2 13 0 0 13 13 13 10 Ankyrin repeat Arm-DNA-bind_3 PF13356.6 ELR11667.1 - 0.31 11.4 2.4 34 4.9 0.2 4.0 3 1 0 3 3 3 0 Arm DNA-binding domain Bromodomain PF00439.25 ELR11668.1 - 9.5e-21 73.7 0.2 3.1e-20 72.0 0.2 1.9 1 0 0 1 1 1 1 Bromodomain PCAF_N PF06466.11 ELR11668.1 - 1.5e-19 70.6 0.4 5e-13 49.2 0.0 2.4 2 0 0 2 2 2 2 PCAF (P300/CBP-associated factor) N-terminal domain Acetyltransf_1 PF00583.25 ELR11668.1 - 2.8e-13 50.1 0.0 5.9e-13 49.1 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 ELR11668.1 - 1.6e-10 41.0 0.0 3.7e-10 39.8 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 ELR11668.1 - 2.9e-09 37.2 0.2 5.5e-09 36.3 0.2 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 ELR11668.1 - 0.0052 16.7 0.0 0.011 15.7 0.0 1.5 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_4 PF13420.7 ELR11668.1 - 0.052 13.7 0.0 0.14 12.3 0.0 1.7 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Myb_DNA-binding PF00249.31 ELR11669.1 - 1e-05 25.6 0.0 2.2e-05 24.6 0.0 1.5 1 0 0 1 1 1 1 Myb-like DNA-binding domain SPX PF03105.19 ELR11669.1 - 2.4 8.0 8.5 0.25 11.2 2.7 2.0 2 0 0 2 2 2 0 SPX domain Beta_helix PF13229.6 ELR11671.1 - 1.4e-30 106.3 35.6 3.7e-15 56.1 11.4 5.0 1 1 3 4 4 4 4 Right handed beta helix region NosD PF05048.13 ELR11671.1 - 1e-19 70.8 28.9 1.8e-10 40.5 9.8 4.8 1 1 3 4 4 4 4 Periplasmic copper-binding protein (NosD) TIG_2 PF18020.1 ELR11671.1 - 0.096 13.3 0.2 27 5.5 0.0 2.7 2 0 0 2 2 2 0 TIG domain found in plexin ABC2_membrane PF01061.24 ELR11672.1 - 2e-45 154.8 15.9 3.2e-45 154.1 15.9 1.3 1 0 0 1 1 1 1 ABC-2 type transporter ABC_tran PF00005.27 ELR11672.1 - 1.5e-17 64.4 0.2 3.4e-17 63.2 0.0 1.7 2 0 0 2 2 2 1 ABC transporter ABC2_membrane_3 PF12698.7 ELR11672.1 - 4.1e-05 22.9 12.7 4.1e-05 22.9 12.7 1.5 1 1 0 1 1 1 1 ABC-2 family transporter protein ABC2_membrane_2 PF12679.7 ELR11672.1 - 0.055 12.7 11.2 0.43 9.8 11.2 2.2 1 1 0 1 1 1 0 ABC-2 family transporter protein TP53IP5 PF15331.6 ELR11672.1 - 0.65 10.1 4.7 1.1 9.3 0.4 2.1 2 0 0 2 2 2 0 Cellular tumour antigen p53-inducible 5 Ribosomal_L6e PF01159.19 ELR11672.1 - 1.5 9.4 7.0 11 6.6 1.3 2.4 2 0 0 2 2 2 0 Ribosomal protein L6e Vfa1 PF08432.10 ELR11672.1 - 9 6.6 8.3 1.9 8.8 1.4 2.2 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 OB_NTP_bind PF07717.16 ELR11673.1 - 1e-13 51.5 0.0 2.3e-13 50.3 0.0 1.6 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold HA2 PF04408.23 ELR11673.1 - 2.5e-13 50.3 0.0 2.5e-13 50.3 0.0 3.1 2 2 0 2 2 1 1 Helicase associated domain (HA2) Helicase_C PF00271.31 ELR11673.1 - 1.1e-12 48.2 0.0 3.3e-12 46.7 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 ELR11673.1 - 0.00022 21.1 0.1 0.00071 19.4 0.1 1.8 1 1 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 ELR11673.1 - 0.03 14.6 0.2 0.12 12.7 0.2 2.0 1 1 0 1 1 1 0 AAA domain T2SSE PF00437.20 ELR11673.1 - 0.033 13.2 0.0 0.059 12.4 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein ATPase PF06745.13 ELR11673.1 - 0.036 13.4 0.0 0.076 12.4 0.0 1.5 1 0 0 1 1 1 0 KaiC AAA_25 PF13481.6 ELR11673.1 - 0.089 12.4 0.5 0.25 10.9 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_29 PF13555.6 ELR11673.1 - 0.093 12.5 0.0 0.21 11.4 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_23 PF13476.6 ELR11673.1 - 0.17 12.3 0.0 0.17 12.3 0.0 2.7 2 1 1 3 3 2 0 AAA domain Rad17 PF03215.15 ELR11673.1 - 0.19 11.6 0.0 0.36 10.7 0.0 1.4 1 0 0 1 1 1 0 Rad17 P-loop domain ResIII PF04851.15 ELR11673.1 - 0.29 11.1 2.8 1.4 8.9 0.0 3.1 2 1 1 3 3 3 0 Type III restriction enzyme, res subunit zf-C2H2_4 PF13894.6 ELR11673.1 - 4.9 8.3 6.7 1.5 9.8 0.3 3.1 2 1 0 2 2 2 0 C2H2-type zinc finger ADH_zinc_N PF00107.26 ELR11674.1 - 3.7e-18 65.7 0.4 7e-18 64.9 0.4 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 ELR11674.1 - 1.5e-07 31.3 4.5 2.5e-06 27.4 4.5 2.5 1 1 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain AlaDh_PNT_C PF01262.21 ELR11674.1 - 3.8e-06 26.4 0.7 3.8e-06 26.4 0.7 1.8 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain 2-Hacid_dh_C PF02826.19 ELR11674.1 - 4.4e-05 22.9 0.3 0.00011 21.6 0.3 1.7 1 1 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_binding_10 PF13460.6 ELR11674.1 - 0.0019 18.1 0.7 0.0019 18.1 0.7 1.4 2 0 0 2 2 2 1 NAD(P)H-binding DUF4350 PF14258.6 ELR11674.1 - 0.0023 18.3 2.5 0.0046 17.4 1.0 2.3 2 1 0 2 2 2 1 Domain of unknown function (DUF4350) ADH_zinc_N_2 PF13602.6 ELR11674.1 - 0.0039 18.3 0.3 0.0063 17.6 0.3 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Oxidored_nitro PF00148.19 ELR11674.1 - 0.012 14.4 0.0 0.018 13.8 0.0 1.3 1 0 0 1 1 1 0 Nitrogenase component 1 type Oxidoreductase XdhC_C PF13478.6 ELR11674.1 - 0.016 15.7 1.1 0.13 12.8 1.1 2.1 1 1 0 1 1 1 0 XdhC Rossmann domain NAD_binding_7 PF13241.6 ELR11674.1 - 0.022 15.2 0.3 0.051 14.0 0.2 1.7 1 1 0 1 1 1 0 Putative NAD(P)-binding TrkA_N PF02254.18 ELR11674.1 - 0.023 15.0 0.7 0.05 13.9 0.3 1.8 2 0 0 2 2 2 0 TrkA-N domain 3HCDH_N PF02737.18 ELR11674.1 - 0.024 14.5 1.3 0.045 13.6 1.3 1.5 1 1 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Methyltransf_11 PF08241.12 ELR11674.1 - 0.035 14.7 0.1 0.075 13.7 0.1 1.5 1 0 0 1 1 1 0 Methyltransferase domain GFO_IDH_MocA PF01408.22 ELR11674.1 - 0.042 14.7 0.1 0.084 13.7 0.1 1.5 1 0 0 1 1 1 0 Oxidoreductase family, NAD-binding Rossmann fold Aldo_ket_red PF00248.21 ELR11675.1 - 1.1e-37 129.9 0.0 1.3e-37 129.7 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family zf-MYND PF01753.18 ELR11676.1 - 2.4e-10 40.3 17.5 2.4e-10 40.3 17.5 2.5 2 0 0 2 2 2 1 MYND finger Ank_4 PF13637.6 ELR11676.1 - 7e-06 26.5 0.4 0.00013 22.4 0.0 3.1 2 1 1 3 3 3 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 ELR11676.1 - 1.2e-05 25.8 0.2 0.0013 19.2 0.0 3.6 2 2 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 ELR11676.1 - 0.01 16.3 0.2 8.2 7.4 0.0 3.5 3 0 0 3 3 3 0 Ankyrin repeat TPR_2 PF07719.17 ELR11676.1 - 0.036 14.2 3.6 0.91 9.8 0.3 4.2 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_1 PF00515.28 ELR11676.1 - 0.089 12.7 1.7 2.2 8.3 0.1 3.7 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_12 PF13424.6 ELR11676.1 - 0.21 11.9 7.4 7.9 6.9 2.5 4.4 4 1 0 4 4 4 0 Tetratricopeptide repeat TPR_19 PF14559.6 ELR11676.1 - 0.23 12.0 4.0 0.39 11.3 0.7 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_14 PF13428.6 ELR11676.1 - 0.89 10.5 4.9 13 6.9 0.1 4.2 4 0 0 4 4 4 0 Tetratricopeptide repeat DUF167 PF02594.16 ELR11677.1 - 1.9e-24 85.5 0.5 2.4e-24 85.2 0.5 1.1 1 0 0 1 1 1 1 Uncharacterised ACR, YggU family COG1872 Pilosulin PF17499.2 ELR11677.1 - 0.015 15.5 0.1 0.019 15.1 0.1 1.2 1 0 0 1 1 1 0 Ant venom peptides NTP_transf_7 PF07984.12 ELR11678.1 - 1.1e-29 103.7 0.0 2.3e-17 63.2 0.0 2.1 2 0 0 2 2 2 2 Nucleotidyltransferase Avl9 PF09794.9 ELR11679.1 - 9e-06 24.6 0.1 1.3e-05 24.1 0.1 1.2 1 0 0 1 1 1 1 Transport protein Avl9 SPA PF08616.10 ELR11679.1 - 0.00043 20.2 0.0 0.00087 19.2 0.0 1.4 1 0 0 1 1 1 1 Stabilization of polarity axis SPX PF03105.19 ELR11679.1 - 1.3 8.8 12.0 0.098 12.6 6.6 1.9 2 0 0 2 2 2 0 SPX domain HEAT PF02985.22 ELR11680.1 - 0.24 11.8 2.1 28 5.3 0.4 3.3 3 0 0 3 3 3 0 HEAT repeat HEAT_EZ PF13513.6 ELR11681.1 - 0.0012 19.3 6.5 0.01 16.3 0.0 4.5 4 1 0 4 4 4 1 HEAT-like repeat HEAT_2 PF13646.6 ELR11681.1 - 0.037 14.4 1.3 0.36 11.3 0.4 2.9 2 1 0 2 2 2 0 HEAT repeats HEAT PF02985.22 ELR11681.1 - 0.16 12.3 0.9 1.6 9.2 0.1 3.1 2 0 0 2 2 2 0 HEAT repeat F-box-like PF12937.7 ELR11682.1 - 3.9e-10 39.5 1.3 1.1e-09 38.0 1.3 1.8 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ELR11682.1 - 2.9e-07 30.2 0.8 6.9e-07 29.0 0.8 1.6 1 0 0 1 1 1 1 F-box domain EF-hand_1 PF00036.32 ELR11683.1 - 2.4e-14 51.7 4.2 1.8e-05 23.9 0.0 4.8 4 1 1 5 5 5 3 EF hand EF-hand_7 PF13499.6 ELR11683.1 - 1.1e-12 48.2 0.9 4.2e-06 27.1 0.2 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 ELR11683.1 - 2.1e-12 45.9 2.5 0.00026 20.7 0.3 3.9 3 1 0 3 3 3 3 EF-hand domain EF-hand_8 PF13833.6 ELR11683.1 - 2.8e-12 46.3 4.9 7e-08 32.2 0.2 3.0 1 1 2 3 3 3 3 EF-hand domain pair EF-hand_9 PF14658.6 ELR11683.1 - 8.3e-05 22.8 0.2 0.22 11.9 0.0 2.4 2 1 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.7 ELR11683.1 - 0.1 12.6 0.3 18 5.3 0.0 2.5 1 1 1 2 2 2 0 Cytoskeletal-regulatory complex EF hand F-box-like PF12937.7 ELR11684.1 - 2.7e-10 40.0 0.3 4.6e-10 39.2 0.3 1.4 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ELR11684.1 - 1.5e-07 31.1 0.1 2.4e-07 30.5 0.1 1.3 1 0 0 1 1 1 1 F-box domain PRANC PF09372.10 ELR11684.1 - 0.0041 17.4 0.0 0.012 16.0 0.0 1.7 2 0 0 2 2 2 1 PRANC domain Ank_2 PF12796.7 ELR11685.1 - 8.3e-35 119.2 10.0 1.8e-14 54.1 1.9 3.3 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ELR11685.1 - 2.6e-31 107.6 3.7 8.2e-08 32.7 0.2 5.0 3 2 2 5 5 5 5 Ankyrin repeats (many copies) Ank PF00023.30 ELR11685.1 - 7.7e-31 105.2 11.7 5.3e-05 23.5 0.6 6.3 6 0 0 6 6 6 6 Ankyrin repeat Ank_5 PF13857.6 ELR11685.1 - 2.6e-28 97.7 12.6 4.7e-07 29.9 1.0 5.8 1 1 5 6 6 6 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 ELR11685.1 - 6.5e-27 90.6 8.2 0.002 18.5 0.1 6.2 6 0 0 6 6 6 6 Ankyrin repeat Peptidase_M16 PF00675.20 ELR11685.1 - 0.0073 16.3 0.4 0.31 11.0 0.0 2.8 2 1 1 3 3 3 1 Insulinase (Peptidase family M16) TFIIE_alpha PF02002.17 ELR11685.1 - 0.13 12.1 0.0 0.25 11.2 0.0 1.5 1 0 0 1 1 1 0 TFIIE alpha subunit Kelch_6 PF13964.6 ELR11686.1 - 1e-32 111.3 17.6 5.5e-09 36.0 0.1 6.4 6 0 0 6 6 6 6 Kelch motif Kelch_4 PF13418.6 ELR11686.1 - 4.3e-32 109.9 20.1 5.6e-08 32.7 0.1 7.1 6 1 1 7 7 7 6 Galactose oxidase, central domain Kelch_3 PF13415.6 ELR11686.1 - 7.7e-32 109.0 16.3 1.7e-09 37.7 0.4 7.9 8 0 0 8 8 8 4 Galactose oxidase, central domain Kelch_5 PF13854.6 ELR11686.1 - 4.3e-31 106.4 26.7 4.9e-09 36.0 1.1 6.4 6 0 0 6 6 6 6 Kelch motif Kelch_1 PF01344.25 ELR11686.1 - 6.2e-30 102.5 22.2 2.2e-09 36.8 0.2 6.7 6 0 0 6 6 6 5 Kelch motif Kelch_2 PF07646.15 ELR11686.1 - 2.2e-25 87.6 23.0 4.9e-06 26.3 0.1 6.6 6 0 0 6 6 6 5 Kelch motif BTB PF00651.31 ELR11686.1 - 8.6e-20 71.0 0.0 1.5e-19 70.2 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain RAG2 PF03089.14 ELR11686.1 - 0.047 12.7 3.4 1.2 8.0 0.0 3.3 4 0 0 4 4 4 0 Recombination activating protein 2 CHAP PF05257.16 ELR11686.1 - 0.12 13.0 2.0 5.1 7.7 0.0 3.6 3 0 0 3 3 3 0 CHAP domain BSP_II PF05432.11 ELR11686.1 - 0.48 10.1 9.1 0.71 9.5 9.1 1.2 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) RhoGEF PF00621.20 ELR11687.1 - 1.1e-47 162.6 0.2 1.7e-47 162.0 0.2 1.3 1 0 0 1 1 1 1 RhoGEF domain PH PF00169.29 ELR11687.1 - 0.00013 22.4 0.1 0.00028 21.3 0.1 1.5 1 0 0 1 1 1 1 PH domain PH_5 PF15405.6 ELR11687.1 - 0.057 13.5 0.3 0.13 12.3 0.3 1.6 1 0 0 1 1 1 0 Pleckstrin homology domain Ribosomal_L22e PF01776.17 ELR11687.1 - 0.08 13.3 2.1 1.9 8.9 0.2 3.1 2 1 0 2 2 2 0 Ribosomal L22e protein family PMT_4TMC PF16192.5 ELR11687.1 - 0.33 10.5 4.4 0.54 9.8 1.1 2.4 2 0 0 2 2 2 0 C-terminal four TMM region of protein-O-mannosyltransferase Ribonuc_2-5A PF06479.12 ELR11688.1 - 6.3e-38 129.8 0.3 8.3e-37 126.2 0.1 2.2 2 0 0 2 2 2 1 Ribonuclease 2-5A Pkinase PF00069.25 ELR11688.1 - 8e-33 113.9 0.0 1.5e-30 106.4 0.0 3.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR11688.1 - 2.2e-22 79.6 0.0 4.7e-22 78.5 0.0 1.6 1 1 0 1 1 1 1 Protein tyrosine kinase PQQ_2 PF13360.6 ELR11688.1 - 1.8e-13 50.6 0.6 1e-06 28.6 0.0 2.5 1 1 1 2 2 2 2 PQQ-like domain PQQ PF01011.21 ELR11688.1 - 2.7e-11 42.8 0.1 0.00099 18.9 0.0 5.0 5 0 0 5 5 5 2 PQQ enzyme repeat PQQ_3 PF13570.6 ELR11688.1 - 2.1e-05 24.8 1.4 8.7 7.0 0.0 5.9 6 0 0 6 6 6 1 PQQ-like domain Pkinase_fungal PF17667.1 ELR11688.1 - 0.0004 19.3 0.7 0.0009 18.1 0.6 1.5 1 1 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 ELR11688.1 - 0.012 15.0 0.0 0.019 14.3 0.0 1.2 1 0 0 1 1 1 0 Kinase-like Kdo PF06293.14 ELR11688.1 - 0.022 14.1 0.1 0.045 13.1 0.1 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 ELR11688.1 - 0.076 12.6 0.0 0.16 11.5 0.0 1.5 1 0 0 1 1 1 0 RIO1 family Haspin_kinase PF12330.8 ELR11688.1 - 0.085 11.8 0.1 0.16 10.9 0.1 1.4 1 0 0 1 1 1 0 Haspin like kinase domain Shisa PF13908.6 ELR11688.1 - 0.2 11.9 0.0 0.46 10.7 0.0 1.6 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator APH PF01636.23 ELR11688.1 - 0.29 11.0 3.7 0.24 11.3 0.7 2.3 2 1 1 3 3 3 0 Phosphotransferase enzyme family CDC45 PF02724.14 ELR11688.1 - 4.7 5.4 15.7 0.97 7.7 11.4 1.8 2 0 0 2 2 2 0 CDC45-like protein GST_N_3 PF13417.6 ELR11689.1 - 8.3e-13 48.6 0.0 8.4e-12 45.3 0.0 2.2 1 1 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_5 PF16865.5 ELR11689.1 - 1.4e-12 48.2 0.0 2.2e-12 47.5 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.6 ELR11689.1 - 2.5e-12 46.9 0.1 2.1e-11 44.0 0.1 2.2 1 1 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 ELR11689.1 - 1.3e-09 38.0 0.1 2.4e-09 37.1 0.1 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 ELR11689.1 - 1.4e-09 38.1 0.0 5.4e-08 33.1 0.0 2.5 1 1 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 ELR11689.1 - 5.1e-06 26.6 0.0 8.5e-06 25.9 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 ELR11689.1 - 0.00011 22.4 0.0 0.00017 21.7 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Cyclin_N PF00134.23 ELR11690.1 - 3.1e-15 56.0 0.5 9.6e-13 48.0 0.3 2.2 2 0 0 2 2 2 2 Cyclin, N-terminal domain Cyclin_C PF02984.19 ELR11690.1 - 2.9e-07 30.6 0.0 1.2e-06 28.6 0.0 1.9 2 0 0 2 2 2 1 Cyclin, C-terminal domain TFIIB PF00382.19 ELR11690.1 - 0.00025 21.0 0.2 0.0028 17.7 0.1 2.2 2 0 0 2 2 2 1 Transcription factor TFIIB repeat ApbA PF02558.16 ELR11691.1 - 1.3e-26 93.1 0.8 2.1e-26 92.4 0.8 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA ApbA_C PF08546.11 ELR11691.1 - 3.4e-20 72.5 0.0 6.8e-20 71.5 0.0 1.5 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA C terminal HTH_32 PF13565.6 ELR11691.1 - 0.17 12.5 2.9 0.33 11.6 0.5 2.7 3 0 0 3 3 3 0 Homeodomain-like domain Peptidase_S28 PF05577.12 ELR11692.1 - 1.3e-66 225.2 0.0 1.5e-66 225.0 0.0 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase S28 Hydrolase_4 PF12146.8 ELR11692.1 - 8.8e-05 21.9 0.0 0.00015 21.1 0.0 1.4 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Peptidase_S9 PF00326.21 ELR11692.1 - 0.0081 15.7 0.0 0.014 14.9 0.0 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_6 PF12697.7 ELR11692.1 - 4.1 8.0 8.6 0.25 11.9 0.5 2.4 2 1 0 3 3 3 0 Alpha/beta hydrolase family Pkinase_Tyr PF07714.17 ELR11693.1 - 8.4e-127 421.8 0.0 5.3e-63 212.7 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 ELR11693.1 - 4.5e-110 367.2 0.0 3.5e-55 187.2 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain PBP_like_2 PF12849.7 ELR11693.1 - 2.8e-33 115.8 10.3 3.8e-19 69.4 0.2 2.5 3 0 0 3 3 3 2 PBP superfamily domain Guanylate_cyc PF00211.20 ELR11693.1 - 9.2e-15 54.7 0.0 1.4e-14 54.1 0.0 1.3 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain APH PF01636.23 ELR11693.1 - 4e-08 33.5 0.0 9.4e-05 22.4 0.0 2.8 2 0 0 2 2 2 2 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 ELR11693.1 - 0.00012 21.0 0.1 0.3 9.8 0.0 2.4 2 0 0 2 2 2 2 Fungal protein kinase Haspin_kinase PF12330.8 ELR11693.1 - 0.00016 20.7 0.0 0.021 13.8 0.0 2.3 2 0 0 2 2 2 1 Haspin like kinase domain Kinase-like PF14531.6 ELR11693.1 - 0.00054 19.4 0.0 0.36 10.1 0.0 2.3 2 0 0 2 2 2 2 Kinase-like Kdo PF06293.14 ELR11693.1 - 0.007 15.7 1.5 0.86 8.9 0.2 2.5 2 0 0 2 2 2 2 Lipopolysaccharide kinase (Kdo/WaaP) family TMEM154 PF15102.6 ELR11693.1 - 0.027 14.4 0.2 0.1 12.5 0.0 2.0 2 0 0 2 2 2 0 TMEM154 protein family EGF_2 PF07974.13 ELR11693.1 - 0.03 14.7 10.2 0.059 13.7 10.2 1.5 1 0 0 1 1 1 0 EGF-like domain RIO1 PF01163.22 ELR11693.1 - 0.26 10.9 1.6 12 5.5 0.2 2.5 2 1 0 2 2 2 0 RIO1 family TFIID-18kDa PF02269.16 ELR11694.1 - 2.8e-15 56.1 0.0 6.6e-15 54.9 0.0 1.6 1 0 0 1 1 1 1 Transcription initiation factor IID, 18kD subunit TAFII28 PF04719.14 ELR11694.1 - 0.00031 20.8 0.0 0.0011 19.1 0.0 2.0 2 1 0 2 2 2 1 hTAFII28-like protein conserved region Histone PF00125.24 ELR11694.1 - 0.13 12.6 3.1 0.28 11.6 0.0 2.4 2 0 0 2 2 2 0 Core histone H2A/H2B/H3/H4 MORN PF02493.20 ELR11695.1 - 0.11 12.5 0.8 2.3 8.3 0.4 3.2 3 0 0 3 3 3 0 MORN repeat DUF5308 PF17233.2 ELR11695.1 - 0.25 11.6 2.4 4.7 7.4 0.3 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF5308) CDC45 PF02724.14 ELR11695.1 - 0.26 9.5 22.6 0.012 13.9 9.6 2.1 2 0 0 2 2 2 0 CDC45-like protein SAPS PF04499.15 ELR11695.1 - 0.33 9.7 8.9 0.095 11.5 2.1 2.0 2 0 0 2 2 2 0 SIT4 phosphatase-associated protein Ycf1 PF05758.12 ELR11695.1 - 0.51 8.2 4.4 0.76 7.6 4.4 1.2 1 0 0 1 1 1 0 Ycf1 SDA1 PF05285.12 ELR11695.1 - 6.7 6.0 35.4 0.053 13.0 17.7 2.1 2 0 0 2 2 2 0 SDA1 FYDLN_acid PF09538.10 ELR11695.1 - 6.8 7.4 26.8 14 6.4 14.2 2.6 2 0 0 2 2 2 0 Protein of unknown function (FYDLN_acid) Sigma70_ner PF04546.13 ELR11695.1 - 8.1 6.3 26.7 2.1 8.2 13.6 2.7 3 0 0 3 3 3 0 Sigma-70, non-essential region Clathrin_H_link PF13838.6 ELR11696.1 - 1.4e-13 50.5 2.5 1.5e-13 50.4 0.7 2.0 2 0 0 2 2 2 1 Clathrin-H-link Clathrin_propel PF01394.20 ELR11696.1 - 8.5e-09 35.3 0.2 0.0045 17.2 0.0 4.7 4 0 0 4 4 4 3 Clathrin propeller repeat Clathrin PF00637.20 ELR11696.1 - 1.6e-08 34.6 0.0 3.6e-08 33.4 0.0 1.6 1 0 0 1 1 1 1 Region in Clathrin and VPS VIT1 PF01988.19 ELR11697.1 - 1e-45 156.3 7.8 1.4e-45 155.9 7.8 1.2 1 0 0 1 1 1 1 VIT family DUF3093 PF11292.8 ELR11697.1 - 0.31 11.3 1.6 15 5.9 0.6 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3093) Lipase_3 PF01764.25 ELR11698.1 - 8e-30 103.6 0.0 1e-29 103.2 0.0 1.1 1 0 0 1 1 1 1 Lipase (class 3) DUF2974 PF11187.8 ELR11698.1 - 0.00023 20.8 0.2 0.29 10.7 0.0 2.3 2 0 0 2 2 2 2 Protein of unknown function (DUF2974) Abhydrolase_5 PF12695.7 ELR11698.1 - 0.074 12.8 0.0 0.11 12.2 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase family RNase_T PF00929.24 ELR11699.1 - 2.5e-10 41.1 0.0 5.6e-10 40.0 0.0 1.5 1 1 0 1 1 1 1 Exonuclease MIT_C PF16565.5 ELR11700.1 - 1.6e-31 109.2 0.0 2.1e-31 108.8 0.0 1.2 1 0 0 1 1 1 1 Phospholipase D-like domain at C-terminus of MIT MIT PF04212.18 ELR11700.1 - 2e-20 72.6 0.2 3.6e-20 71.8 0.2 1.4 1 0 0 1 1 1 1 MIT (microtubule interacting and transport) domain Flg_hook PF02120.16 ELR11700.1 - 0.062 13.2 1.2 0.097 12.6 0.0 1.9 2 0 0 2 2 2 0 Flagellar hook-length control protein FliK UQ_con PF00179.26 ELR11702.1 - 1.4e-16 60.4 0.0 2e-16 59.9 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 ELR11702.1 - 0.0024 18.2 0.0 0.0041 17.4 0.0 1.4 1 0 0 1 1 1 1 RWD domain WD40 PF00400.32 ELR11703.1 - 5.8e-37 125.0 18.6 7.6e-07 29.7 0.2 8.2 8 0 0 8 8 8 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ELR11703.1 - 1.1e-11 44.8 1.2 0.11 12.8 0.0 5.3 1 1 4 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain F-box-like PF12937.7 ELR11703.1 - 2e-07 30.8 0.3 7.2e-07 29.0 0.3 2.0 1 0 0 1 1 1 1 F-box-like Nup160 PF11715.8 ELR11703.1 - 2.3e-06 26.6 6.1 0.007 15.1 0.3 4.7 2 2 2 5 5 5 2 Nucleoporin Nup120/160 F-box PF00646.33 ELR11703.1 - 3.4e-05 23.6 0.2 9.3e-05 22.2 0.2 1.7 1 0 0 1 1 1 1 F-box domain WD40_like PF17005.5 ELR11703.1 - 6.3e-05 22.4 0.0 0.17 11.2 0.0 3.1 1 1 3 4 4 4 1 WD40-like domain BBS2_Mid PF14783.6 ELR11703.1 - 0.0002 21.3 0.1 2 8.5 0.0 4.2 2 1 1 4 4 4 2 Ciliary BBSome complex subunit 2, middle region eIF2A PF08662.11 ELR11703.1 - 0.03 14.2 0.0 0.46 10.3 0.0 2.6 2 1 1 3 3 3 0 Eukaryotic translation initiation factor eIF2A DUF5046 PF16465.5 ELR11703.1 - 0.12 11.8 0.5 1.2 8.5 0.2 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF5046) SWIB PF02201.18 ELR11704.1 - 3.9e-21 74.7 0.0 1.3e-20 73.0 0.0 1.9 2 0 0 2 2 2 1 SWIB/MDM2 domain YebG PF07130.12 ELR11704.1 - 0.043 13.7 0.1 0.32 10.9 0.0 2.2 2 0 0 2 2 2 0 YebG protein PBP_like_2 PF12849.7 ELR11706.1 - 1.2e-31 110.5 5.1 8.9e-17 61.7 1.4 2.8 2 1 0 2 2 2 2 PBP superfamily domain Pkinase_Tyr PF07714.17 ELR11706.1 - 3.6e-13 49.4 0.0 5.5e-13 48.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ELR11706.1 - 5.3e-11 42.4 0.0 8.1e-11 41.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain TMEM154 PF15102.6 ELR11706.1 - 0.0022 17.9 0.0 0.0068 16.3 0.0 1.8 1 0 0 1 1 1 1 TMEM154 protein family SKG6 PF08693.10 ELR11706.1 - 0.0036 16.7 2.0 0.012 15.0 2.0 2.0 1 0 0 1 1 1 1 Transmembrane alpha-helix domain Guanylate_cyc PF00211.20 ELR11706.1 - 0.0053 16.4 0.0 0.017 14.8 0.0 1.8 1 1 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain ABC1 PF03109.16 ELR11706.1 - 0.022 14.9 0.0 0.075 13.2 0.0 1.8 1 0 0 1 1 1 0 ABC1 family DUF347 PF03988.12 ELR11706.1 - 6 7.1 6.8 1.5 9.1 1.1 2.9 3 0 0 3 3 3 0 Repeat of Unknown Function (DUF347) Itfg2 PF15907.5 ELR11707.1 - 7.2e-54 183.1 0.0 6.5e-27 94.5 0.0 4.1 4 0 0 4 4 4 3 Integrin-alpha FG-GAP repeat-containing protein 2 BBS1 PF14779.6 ELR11707.1 - 0.00021 20.8 0.0 0.095 12.1 0.0 2.9 3 1 1 4 4 4 2 Ciliary BBSome complex subunit 1 VCBS PF13517.6 ELR11707.1 - 0.00026 21.5 0.2 0.38 11.4 0.3 2.9 2 1 1 3 3 3 3 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella BBS2_Mid PF14783.6 ELR11707.1 - 0.00088 19.3 0.4 9.3 6.3 0.0 3.6 2 1 2 4 4 4 2 Ciliary BBSome complex subunit 2, middle region FG-GAP PF01839.23 ELR11707.1 - 0.13 12.4 7.6 1.3 9.2 0.7 3.0 3 0 0 3 3 3 0 FG-GAP repeat TPMT PF05724.11 ELR11708.1 - 5.5e-14 52.4 0.4 5.2e-12 45.9 0.4 2.5 1 1 0 1 1 1 1 Thiopurine S-methyltransferase (TPMT) Methyltransf_25 PF13649.6 ELR11708.1 - 9.3e-13 48.7 0.2 4.9e-09 36.8 0.1 2.2 1 1 1 2 2 2 2 Methyltransferase domain Methyltransf_23 PF13489.6 ELR11708.1 - 8.3e-12 45.2 0.0 1e-11 45.0 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ELR11708.1 - 1.6e-11 44.7 0.1 1.1e-07 32.4 0.1 2.2 1 1 1 2 2 2 2 Methyltransferase domain Methyltransf_12 PF08242.12 ELR11708.1 - 1.6e-08 35.2 0.0 3.6e-07 30.8 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ELR11708.1 - 2e-07 30.9 0.0 5.9e-07 29.4 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 ELR11708.1 - 0.0016 17.8 0.0 0.0024 17.2 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_24 PF13578.6 ELR11708.1 - 0.0018 19.2 0.1 0.0041 18.1 0.1 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_15 PF09445.10 ELR11708.1 - 0.0051 16.4 0.0 0.0071 15.9 0.0 1.2 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase MTS PF05175.14 ELR11708.1 - 0.01 15.4 0.0 0.03 13.9 0.0 1.6 1 1 1 2 2 2 0 Methyltransferase small domain PrmA PF06325.13 ELR11708.1 - 0.035 13.5 0.0 0.057 12.8 0.0 1.3 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_4 PF02390.17 ELR11708.1 - 0.054 13.0 0.0 0.096 12.1 0.0 1.5 1 0 0 1 1 1 0 Putative methyltransferase Methyltransf_18 PF12847.7 ELR11708.1 - 0.12 12.3 0.0 0.19 11.7 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain PCMT PF01135.19 ELR11708.1 - 0.16 11.7 0.0 0.25 11.0 0.0 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_9 PF08003.11 ELR11708.1 - 0.21 10.5 0.0 0.28 10.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1698) F-box PF00646.33 ELR11710.1 - 3.4e-05 23.6 0.0 7.7e-05 22.5 0.0 1.6 1 0 0 1 1 1 1 F-box domain 2OG-FeII_Oxy_3 PF13640.6 ELR11710.1 - 0.00014 22.6 0.0 0.00026 21.8 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily F-box-like PF12937.7 ELR11710.1 - 0.005 16.7 0.3 0.014 15.3 0.0 1.9 2 0 0 2 2 2 1 F-box-like PhyH PF05721.13 ELR11711.1 - 4.7e-08 33.6 0.4 3.9e-05 24.0 0.2 2.4 2 1 0 2 2 2 2 Phytanoyl-CoA dioxygenase (PhyH) TauD PF02668.16 ELR11711.1 - 7.8e-05 22.6 0.1 0.096 12.5 0.0 2.2 2 0 0 2 2 2 2 Taurine catabolism dioxygenase TauD, TfdA family DUF1479 PF07350.12 ELR11711.1 - 0.12 11.1 0.0 0.67 8.7 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1479) Aminotran_1_2 PF00155.21 ELR11712.1 - 3.1e-56 191.1 0.0 3.9e-56 190.8 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.21 ELR11712.1 - 1.8e-07 30.7 0.0 2.6e-07 30.2 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase DegT_DnrJ_EryC1 PF01041.17 ELR11712.1 - 0.00024 20.5 0.0 0.00037 19.9 0.0 1.2 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_5 PF00266.19 ELR11712.1 - 0.00042 19.4 0.0 0.00064 18.8 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-V Cys_Met_Meta_PP PF01053.20 ELR11712.1 - 0.002 16.7 0.0 0.003 16.2 0.0 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Phospholip_A2_1 PF00068.19 ELR11713.1 - 2.7 8.5 13.3 3.8 8.0 12.9 1.6 1 1 0 1 1 1 0 Phospholipase A2 Erf4 PF10256.9 ELR11714.1 - 0.0006 19.9 0.0 0.11 12.6 0.0 2.4 1 1 0 1 1 1 1 Golgin subfamily A member 7/ERF4 family DUF2207 PF09972.9 ELR11714.1 - 0.041 12.7 1.3 0.053 12.3 1.3 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF3040 PF11239.8 ELR11714.1 - 0.045 14.0 1.2 0.077 13.3 1.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3040) DUF3487 PF11990.8 ELR11714.1 - 0.11 12.4 3.9 0.24 11.3 3.5 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF3487) DUF1129 PF06570.11 ELR11714.1 - 0.22 11.0 1.1 0.31 10.5 1.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1129) BTB PF00651.31 ELR11715.1 - 1.6e-11 44.4 0.0 8.1e-11 42.1 0.0 2.0 2 0 0 2 2 2 1 BTB/POZ domain 2OG-FeII_Oxy PF03171.20 ELR11716.1 - 5.3e-24 84.6 0.0 1.5e-23 83.1 0.0 2.0 2 1 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily DIOX_N PF14226.6 ELR11716.1 - 6.9e-24 84.9 0.0 1.1e-23 84.2 0.0 1.3 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal RCC1 PF00415.18 ELR11717.1 - 2.2e-61 204.3 31.6 3.7e-13 49.9 1.1 8.8 9 0 0 9 9 9 7 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 ELR11717.1 - 1.1e-40 136.7 38.5 1.2e-08 34.6 4.6 7.6 7 0 0 7 7 7 7 Regulator of chromosome condensation (RCC1) repeat Clathrin PF00637.20 ELR11717.1 - 1.1e-06 28.6 1.0 0.002 18.0 0.1 2.8 2 1 1 3 3 3 2 Region in Clathrin and VPS GATA PF00320.27 ELR11718.1 - 1.1e-11 44.1 2.5 1.9e-11 43.3 2.5 1.4 1 0 0 1 1 1 1 GATA zinc finger ArfGap PF01412.18 ELR11718.1 - 0.11 12.6 0.1 0.2 11.8 0.1 1.3 1 0 0 1 1 1 0 Putative GTPase activating protein for Arf Cas_CXXC_CXXC PF09706.10 ELR11718.1 - 1.8 8.9 3.3 22 5.4 0.2 2.3 1 1 1 2 2 2 0 CRISPR-associated protein (Cas_CXXC_CXXC) BTB PF00651.31 ELR11719.1 - 6.4e-13 48.9 1.9 5.5e-07 29.8 0.1 3.3 1 1 2 3 3 3 3 BTB/POZ domain BACK PF07707.15 ELR11719.1 - 0.00013 22.0 0.8 0.00051 20.1 0.2 2.2 2 1 1 3 3 3 1 BTB And C-terminal Kelch Pkinase_Tyr PF07714.17 ELR11720.1 - 1.3e-120 401.5 0.0 3e-59 200.4 0.0 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 ELR11720.1 - 1.5e-108 362.2 0.0 4.6e-53 180.3 0.0 2.5 2 0 0 2 2 2 2 Protein kinase domain PBP_like_2 PF12849.7 ELR11720.1 - 3.8e-34 118.6 12.1 3.6e-21 76.1 3.4 2.4 2 0 0 2 2 2 2 PBP superfamily domain Guanylate_cyc PF00211.20 ELR11720.1 - 5.1e-09 36.0 0.0 1e-08 35.0 0.0 1.4 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain APH PF01636.23 ELR11720.1 - 3.3e-07 30.5 0.2 0.0011 19.0 0.0 3.7 3 0 0 3 3 3 2 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 ELR11720.1 - 0.00028 19.8 0.0 0.13 11.1 0.0 2.4 2 0 0 2 2 2 2 Fungal protein kinase Haspin_kinase PF12330.8 ELR11720.1 - 0.00029 19.9 0.2 0.015 14.2 0.0 2.3 2 0 0 2 2 2 1 Haspin like kinase domain Kdo PF06293.14 ELR11720.1 - 0.0012 18.3 0.5 0.79 9.0 0.0 2.3 2 0 0 2 2 2 2 Lipopolysaccharide kinase (Kdo/WaaP) family ABC1 PF03109.16 ELR11720.1 - 0.0034 17.5 0.0 0.042 14.0 0.0 2.5 2 0 0 2 2 2 1 ABC1 family EGF_2 PF07974.13 ELR11720.1 - 0.0084 16.5 7.5 0.023 15.1 7.5 1.8 1 0 0 1 1 1 1 EGF-like domain Kinase-like PF14531.6 ELR11720.1 - 0.012 15.0 0.0 0.79 9.0 0.0 2.3 2 0 0 2 2 2 0 Kinase-like RIO1 PF01163.22 ELR11720.1 - 0.042 13.4 0.9 2.3 7.8 0.1 2.4 2 0 0 2 2 2 0 RIO1 family FTA2 PF13095.6 ELR11720.1 - 0.11 12.1 0.0 1 9.0 0.0 2.5 2 1 1 3 3 3 0 Kinetochore Sim4 complex subunit FTA2 HMD PF03201.16 ELR11720.1 - 0.39 11.0 1.8 0.92 9.8 0.1 2.5 3 0 0 3 3 2 0 H2-forming N5,N10-methylene-tetrahydromethanopterin dehydrogenase EGF_Tenascin PF18720.1 ELR11720.1 - 3.8 7.7 16.8 0.051 13.6 9.1 1.9 2 0 0 2 2 1 0 Tenascin EGF domain ThiF PF00899.21 ELR11721.1 - 7.9e-96 320.1 0.0 7.1e-66 222.0 0.0 2.2 2 0 0 2 2 2 2 ThiF family UBA_e1_thiolCys PF10585.9 ELR11721.1 - 5.2e-84 282.1 0.5 9.4e-84 281.3 0.5 1.4 1 0 0 1 1 1 1 Ubiquitin-activating enzyme active site E1_4HB PF16191.5 ELR11721.1 - 8.3e-28 96.4 1.0 3.1e-27 94.6 0.7 2.3 2 0 0 2 2 2 1 Ubiquitin-activating enzyme E1 four-helix bundle E1_UFD PF09358.10 ELR11721.1 - 2.7e-20 72.9 0.0 8.5e-20 71.3 0.0 1.8 1 0 0 1 1 1 1 Ubiquitin fold domain E1_FCCH PF16190.5 ELR11721.1 - 8.1e-17 61.2 0.1 2e-16 59.9 0.1 1.7 1 0 0 1 1 1 1 Ubiquitin-activating enzyme E1 FCCH domain Phage_mat-A PF03863.13 ELR11721.1 - 0.019 13.9 0.0 0.04 12.8 0.0 1.4 1 0 0 1 1 1 0 Phage maturation protein RabGAP-TBC PF00566.18 ELR11722.1 - 6.7e-13 48.8 0.1 3.8e-06 26.7 0.3 2.2 1 1 1 2 2 2 2 Rab-GTPase-TBC domain Pkinase_Tyr PF07714.17 ELR11723.1 - 8.8e-129 428.3 0.0 3e-63 213.5 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 ELR11723.1 - 9.2e-110 366.1 0.0 3e-55 187.4 0.0 2.7 3 0 0 3 3 3 2 Protein kinase domain PBP_like_2 PF12849.7 ELR11723.1 - 5.6e-28 98.4 16.1 4.8e-14 52.7 2.0 2.4 2 0 0 2 2 2 2 PBP superfamily domain APH PF01636.23 ELR11723.1 - 5e-07 29.9 0.1 0.00027 21.0 0.0 2.8 2 0 0 2 2 2 2 Phosphotransferase enzyme family Guanylate_cyc PF00211.20 ELR11723.1 - 8.4e-05 22.3 0.0 0.0003 20.5 0.0 1.9 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain Haspin_kinase PF12330.8 ELR11723.1 - 0.00031 19.8 0.1 0.017 14.1 0.0 2.3 2 0 0 2 2 2 1 Haspin like kinase domain Kdo PF06293.14 ELR11723.1 - 0.00069 19.0 0.5 0.23 10.8 0.1 2.4 2 0 0 2 2 2 2 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 ELR11723.1 - 0.0028 17.0 0.0 0.89 8.8 0.0 2.4 2 0 0 2 2 2 2 Kinase-like FTA2 PF13095.6 ELR11723.1 - 0.0044 16.7 0.2 0.26 10.9 0.0 3.1 2 2 0 3 3 3 1 Kinetochore Sim4 complex subunit FTA2 Pkinase_fungal PF17667.1 ELR11723.1 - 0.0062 15.4 0.0 1.8 7.2 0.0 2.3 2 0 0 2 2 2 2 Fungal protein kinase TMEM154 PF15102.6 ELR11723.1 - 0.0087 16.0 0.0 0.03 14.2 0.0 1.8 1 0 0 1 1 1 1 TMEM154 protein family EGF_2 PF07974.13 ELR11723.1 - 0.33 11.3 13.1 0.64 10.4 13.1 1.5 1 0 0 1 1 1 0 EGF-like domain EB PF01683.18 ELR11723.1 - 0.64 10.4 6.5 1.8 9.0 6.5 1.7 1 0 0 1 1 1 0 EB module PARP PF00644.20 ELR11724.1 - 3.8e-13 49.5 0.2 3.8e-13 49.5 0.2 2.2 3 0 0 3 3 3 1 Poly(ADP-ribose) polymerase catalytic domain ARTD15_N PF18084.1 ELR11724.1 - 6.6e-09 35.9 0.0 1.8e-08 34.5 0.0 1.8 1 0 0 1 1 1 1 ARTD15 N-terminal domain UBA PF00627.31 ELR11724.1 - 0.0066 16.3 0.0 0.014 15.3 0.0 1.6 1 0 0 1 1 1 1 UBA/TS-N domain Exotox-A_cataly PF09009.10 ELR11724.1 - 0.043 13.6 0.1 0.079 12.7 0.1 1.4 1 0 0 1 1 1 0 Exotoxin A catalytic PTS_2-RNA PF01885.16 ELR11724.1 - 0.065 13.3 0.0 0.11 12.5 0.0 1.3 1 0 0 1 1 1 0 RNA 2'-phosphotransferase, Tpt1 / KptA family NSP10 PF09401.10 ELR11724.1 - 0.065 13.3 0.7 0.86 9.7 0.0 2.4 2 1 0 2 2 2 0 RNA synthesis protein NSP10 FAM199X PF15814.5 ELR11724.1 - 1.4 7.9 8.6 3.8 6.5 8.8 1.5 2 0 0 2 2 2 0 Protein family FAM199X DNA_pol_phi PF04931.13 ELR11724.1 - 1.5 6.9 5.7 2.4 6.1 5.7 1.3 1 0 0 1 1 1 0 DNA polymerase phi CitMHS PF03600.16 ELR11725.1 - 6.1e-22 78.2 67.1 1.1e-17 64.2 39.4 2.4 1 1 1 2 2 2 2 Citrate transporter TrkA_C PF02080.21 ELR11725.1 - 1.7e-16 59.8 1.2 7.1e-07 29.0 0.0 2.6 2 0 0 2 2 2 2 TrkA-C domain LRR_9 PF14580.6 ELR11726.1 - 4.2e-69 231.5 1.3 7.4e-69 230.7 1.3 1.3 1 0 0 1 1 1 1 Leucine-rich repeat LRR_4 PF12799.7 ELR11726.1 - 3.4e-11 43.2 14.2 3.4e-06 27.3 2.7 4.2 3 1 2 5 5 5 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 ELR11726.1 - 1.9e-09 37.1 15.1 7.5e-07 28.8 4.9 3.0 2 1 1 3 3 3 2 Leucine rich repeat PTPS_related PF10131.9 ELR11726.1 - 0.11 10.8 0.0 0.14 10.5 0.0 1.1 1 0 0 1 1 1 0 6-pyruvoyl-tetrahydropterin synthase related domain; membrane protein DUF5137 PF17220.3 ELR11726.1 - 0.46 11.4 2.1 0.68 10.8 1.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF5137) LRR_1 PF00560.33 ELR11726.1 - 9.8 7.2 7.4 61 4.8 0.0 4.5 3 2 0 3 3 3 0 Leucine Rich Repeat Carb_kinase PF01256.17 ELR11728.1 - 3e-47 161.2 0.0 3.9e-47 160.8 0.0 1.1 1 0 0 1 1 1 1 Carbohydrate kinase PAP2 PF01569.21 ELR11729.1 - 2.3e-08 33.9 0.6 7e-08 32.3 0.6 1.8 1 0 0 1 1 1 1 PAP2 superfamily BSD PF03909.17 ELR11729.1 - 0.095 12.7 0.1 0.2 11.7 0.1 1.5 1 0 0 1 1 1 0 BSD domain SAM_1 PF00536.30 ELR11730.1 - 9.8e-14 51.6 0.1 1.8e-13 50.7 0.1 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 ELR11730.1 - 4.7e-13 49.1 0.0 7.5e-13 48.4 0.0 1.3 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) PB1 PF00564.24 ELR11730.1 - 6.6e-06 26.0 0.2 1.1e-05 25.3 0.2 1.4 1 0 0 1 1 1 1 PB1 domain SAM_3 PF18016.1 ELR11730.1 - 0.022 14.6 0.0 0.046 13.5 0.0 1.5 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) SAM_PNT PF02198.16 ELR11730.1 - 0.14 12.1 0.0 0.33 11.0 0.0 1.5 1 0 0 1 1 1 0 Sterile alpha motif (SAM)/Pointed domain Mito_carr PF00153.27 ELR11731.1 - 0.0071 16.2 0.0 0.036 14.0 0.0 2.2 2 0 0 2 2 2 1 Mitochondrial carrier protein Presenilin PF01080.17 ELR11733.1 - 6.2 5.5 10.8 15 4.2 11.0 1.5 1 1 0 1 1 1 0 Presenilin PseudoU_synth_2 PF00849.22 ELR11734.1 - 2.9e-17 63.2 0.0 6.7e-17 62.0 0.0 1.6 1 1 0 1 1 1 1 RNA pseudouridylate synthase MDM1 PF15501.6 ELR11734.1 - 0.025 13.8 15.6 0.04 13.1 15.6 1.3 1 0 0 1 1 1 0 Nuclear protein MDM1 DUF3446 PF11928.8 ELR11734.1 - 0.038 14.3 14.5 0.55 10.6 5.1 3.0 3 0 0 3 3 3 0 Early growth response N-terminal domain Presenilin PF01080.17 ELR11734.1 - 1.2 7.8 10.9 1.7 7.3 10.9 1.2 1 0 0 1 1 1 0 Presenilin Dicty_REP PF05086.12 ELR11734.1 - 2.4 6.0 4.8 3.7 5.4 4.8 1.3 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein DUF4175 PF13779.6 ELR11734.1 - 6.8 4.5 14.6 8.7 4.1 14.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) Sel1 PF08238.12 ELR11735.1 - 9.9e-11 42.0 17.4 0.00032 21.3 0.8 6.8 9 1 0 9 9 9 3 Sel1 repeat DUF1955 PF09205.10 ELR11735.1 - 0.075 12.8 3.6 8.6 6.1 0.1 3.2 3 1 0 3 3 3 0 Domain of unknown function (DUF1955) TPR_19 PF14559.6 ELR11735.1 - 0.17 12.4 0.8 1.1 9.8 0.2 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_14 PF13428.6 ELR11735.1 - 1.1 10.2 7.2 49 5.1 0.0 4.4 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_8 PF13181.6 ELR11735.1 - 5.2 7.6 5.5 9.3 6.8 0.1 4.1 5 0 0 5 5 5 0 Tetratricopeptide repeat DUF4357 PF14267.6 ELR11736.1 - 4.1 7.4 7.6 0.73 9.8 2.6 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4357) Sec7 PF01369.20 ELR11737.1 - 2.1e-44 151.4 0.0 2.8e-44 151.0 0.0 1.1 1 0 0 1 1 1 1 Sec7 domain F-box-like PF12937.7 ELR11737.1 - 2.5e-11 43.3 2.2 5.3e-11 42.2 2.2 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ELR11737.1 - 6.9e-07 29.0 2.2 7.7e-07 28.8 0.6 1.9 2 0 0 2 2 2 1 F-box domain Elongin_A PF06881.11 ELR11737.1 - 0.16 12.5 0.0 0.37 11.3 0.0 1.6 1 0 0 1 1 1 0 RNA polymerase II transcription factor SIII (Elongin) subunit A SR-25 PF10500.9 ELR11737.1 - 5.4 6.6 6.1 11 5.6 1.3 2.3 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein zf-RING_2 PF13639.6 ELR11738.1 - 8.8e-14 51.6 8.9 8.8e-14 51.6 8.9 3.7 3 1 0 3 3 3 1 Ring finger domain zf-C3HC4_2 PF13923.6 ELR11738.1 - 2.8e-10 39.9 8.9 1.2e-09 37.8 8.9 2.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 ELR11738.1 - 5.9e-10 38.7 5.4 5.9e-10 38.7 5.4 2.7 3 0 0 3 3 3 1 RING-like zinc finger zf-C3HC4 PF00097.25 ELR11738.1 - 3.9e-07 29.8 7.2 3.9e-07 29.8 7.2 3.1 3 1 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 ELR11738.1 - 3.4e-06 27.2 12.2 3.4e-06 27.2 12.2 2.8 2 2 0 2 2 2 1 RING-H2 zinc finger domain U-box PF04564.15 ELR11739.1 - 8.6e-24 83.5 0.2 1.5e-23 82.8 0.2 1.4 1 0 0 1 1 1 1 U-box domain zf-Nse PF11789.8 ELR11739.1 - 4.5e-05 23.2 0.0 8.2e-05 22.3 0.0 1.4 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit Trp_oprn_chp PF09534.10 ELR11739.1 - 0.0034 17.2 4.3 0.0062 16.3 4.3 1.4 1 0 0 1 1 1 1 Tryptophan-associated transmembrane protein (Trp_oprn_chp) Rtf2 PF04641.12 ELR11739.1 - 0.008 15.6 5.3 0.053 12.9 0.1 2.5 1 1 2 3 3 3 1 Rtf2 RING-finger DUF4366 PF14283.6 ELR11739.1 - 0.0091 16.1 0.1 0.018 15.1 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4366) zf-NOSIP PF15906.5 ELR11739.1 - 0.014 15.5 0.0 0.028 14.6 0.0 1.4 1 0 0 1 1 1 0 Zinc-finger of nitric oxide synthase-interacting protein zf-rbx1 PF12678.7 ELR11739.1 - 0.039 14.2 0.0 0.092 13.0 0.0 1.7 1 0 0 1 1 1 0 RING-H2 zinc finger domain zf-RING_UBOX PF13445.6 ELR11739.1 - 0.11 12.6 0.0 0.22 11.6 0.0 1.5 1 0 0 1 1 1 0 RING-type zinc-finger Erf4 PF10256.9 ELR11740.1 - 8.6e-11 42.0 0.0 1.3e-10 41.4 0.0 1.2 1 0 0 1 1 1 1 Golgin subfamily A member 7/ERF4 family DUF4131 PF13567.6 ELR11740.1 - 0.01 15.5 0.0 0.017 14.8 0.0 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4131) Meiosis_expr PF15163.6 ELR11740.1 - 0.013 16.2 0.0 0.022 15.4 0.0 1.4 1 0 0 1 1 1 0 Meiosis-expressed Thaumatin PF00314.17 ELR11741.1 - 2.3e-06 27.4 0.0 0.0021 17.7 0.0 2.1 1 1 1 2 2 2 2 Thaumatin family Methyltransf_8 PF05148.15 ELR11742.1 - 4.1e-85 285.1 0.1 5.5e-85 284.7 0.1 1.2 1 0 0 1 1 1 1 Hypothetical methyltransferase Methyltransf_11 PF08241.12 ELR11742.1 - 4.1e-06 27.4 0.1 2.4e-05 24.9 0.0 2.4 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 ELR11742.1 - 0.00017 22.2 0.0 0.0093 16.7 0.0 3.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ELR11742.1 - 0.0079 16.0 0.1 0.4 10.5 0.0 2.5 1 1 0 2 2 2 1 Methyltransferase domain Helicase_C PF00271.31 ELR11743.1 - 1.4e-24 86.6 0.0 2.9e-24 85.6 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain MID_MedPIWI PF18296.1 ELR11743.1 - 0.017 15.0 1.1 0.034 13.9 1.2 1.6 2 0 0 2 2 2 0 MID domain of medPIWI HetR_C PF18460.1 ELR11743.1 - 0.047 13.6 0.5 0.11 12.4 0.0 1.9 2 0 0 2 2 2 0 Heterocyst differentiation regulator C-terminal Hood domain zf-ZPR1 PF03367.13 ELR11743.1 - 0.076 12.9 1.6 0.13 12.1 1.6 1.3 1 0 0 1 1 1 0 ZPR1 zinc-finger domain NBD94 PF16830.5 ELR11743.1 - 0.22 11.9 9.1 0.6 10.5 1.0 2.4 2 0 0 2 2 2 0 Nucleotide-Binding Domain 94 of RH FapA PF03961.13 ELR11743.1 - 1.5 7.3 6.9 2.1 6.9 6.9 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A V_ATPase_I PF01496.19 ELR11743.1 - 2.1 6.2 6.5 2.9 5.7 6.5 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF4407 PF14362.6 ELR11743.1 - 2.5 7.4 7.7 3.3 7.0 7.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) BRF1 PF07741.13 ELR11743.1 - 4.3 7.7 17.9 5.7 7.3 0.1 3.2 2 1 1 3 3 3 0 Brf1-like TBP-binding domain Pup PF05639.11 ELR11743.1 - 4.8 8.2 9.5 0.73 10.8 4.6 2.1 3 0 0 3 3 3 0 Pup-like protein YabA PF06156.13 ELR11743.1 - 5.5 7.7 9.3 5.5 7.7 5.6 2.2 1 1 1 2 2 2 0 Initiation control protein YabA Roc PF08477.13 ELR11744.1 - 0.0022 18.2 0.4 0.16 12.2 0.5 2.3 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase PGM_PMM_II PF02879.16 ELR11745.1 - 4.1e-13 49.8 0.1 7.5e-13 49.0 0.1 1.4 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_III PF02880.16 ELR11745.1 - 4.2e-13 49.5 0.1 6.5e-13 48.9 0.1 1.3 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_IV PF00408.20 ELR11745.1 - 5.8e-06 26.4 0.0 1.4e-05 25.2 0.0 1.6 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain PRiA4_ORF3 PF07929.11 ELR11746.1 - 1.4e-14 54.2 0.0 1.8e-14 53.8 0.0 1.1 1 0 0 1 1 1 1 Plasmid pRiA4b ORF-3-like protein 7TMR-DISMED2 PF07696.11 ELR11747.1 - 0.021 14.9 0.1 0.04 14.0 0.1 1.4 1 0 0 1 1 1 0 7TMR-DISM extracellular 2 Lysyl_oxidase PF01186.17 ELR11749.1 - 1.5e-30 106.4 0.1 1.5e-30 106.4 0.1 2.5 2 0 0 2 2 2 1 Lysyl oxidase PhzC-PhzF PF02567.16 ELR11750.1 - 1.5e-68 231.3 0.0 1.8e-68 231.1 0.0 1.0 1 0 0 1 1 1 1 Phenazine biosynthesis-like protein Pro_racemase PF05544.11 ELR11750.1 - 0.0061 15.6 0.0 0.0096 15.0 0.0 1.2 1 0 0 1 1 1 1 Proline racemase DUF4422 PF14393.6 ELR11751.1 - 0.026 14.4 0.4 0.031 14.1 0.4 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4422) DUF86 PF01934.17 ELR11753.1 - 0.0029 17.5 0.0 0.0095 15.8 0.0 1.8 1 0 0 1 1 1 1 Protein of unknown function DUF86 SfLAP PF11139.8 ELR11753.1 - 0.017 14.5 0.9 0.038 13.4 0.9 1.5 1 0 0 1 1 1 0 Sap, sulfolipid-1-addressing protein Dynamin_M PF01031.20 ELR11753.1 - 0.036 13.3 0.0 0.067 12.4 0.0 1.4 1 0 0 1 1 1 0 Dynamin central region CDKN3 PF05706.12 ELR11754.1 - 0.00015 21.5 0.0 0.00027 20.6 0.0 1.3 1 0 0 1 1 1 1 Cyclin-dependent kinase inhibitor 3 (CDKN3) PTPlike_phytase PF14566.6 ELR11754.1 - 0.0012 19.0 0.0 0.0017 18.5 0.0 1.2 1 0 0 1 1 1 1 Inositol hexakisphosphate Y_phosphatase PF00102.27 ELR11754.1 - 0.0013 18.4 0.0 0.0018 17.9 0.0 1.1 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.6 ELR11754.1 - 0.0023 17.9 0.0 0.0034 17.4 0.0 1.1 1 0 0 1 1 1 1 Tyrosine phosphatase family DSPc PF00782.20 ELR11754.1 - 0.058 13.2 0.0 0.087 12.6 0.0 1.3 1 0 0 1 1 1 0 Dual specificity phosphatase, catalytic domain Methyltransf_23 PF13489.6 ELR11755.1 - 7.8e-08 32.3 0.0 1.3e-07 31.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ELR11755.1 - 6.4e-07 30.0 0.1 1.7e-05 25.5 0.0 2.6 2 1 0 2 2 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ELR11755.1 - 4.7e-06 27.2 0.0 0.00026 21.6 0.0 2.4 1 1 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 ELR11755.1 - 6.4e-06 26.0 0.0 1.1e-05 25.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ELR11755.1 - 5e-05 23.9 0.0 0.0016 19.1 0.0 2.5 1 1 0 1 1 1 1 Methyltransferase domain MetW PF07021.12 ELR11755.1 - 9.6e-05 22.1 0.0 0.00056 19.5 0.0 2.0 2 0 0 2 2 2 1 Methionine biosynthesis protein MetW Methyltransf_32 PF13679.6 ELR11755.1 - 0.0064 16.5 0.1 0.025 14.6 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain MTS PF05175.14 ELR11755.1 - 0.018 14.6 0.0 0.034 13.7 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_18 PF12847.7 ELR11755.1 - 0.023 14.6 0.0 0.036 14.0 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain PrmA PF06325.13 ELR11755.1 - 0.05 13.0 0.0 0.4 10.0 0.0 2.1 2 0 0 2 2 2 0 Ribosomal protein L11 methyltransferase (PrmA) Pox_MCEL PF03291.16 ELR11755.1 - 0.064 12.4 0.0 0.1 11.7 0.0 1.2 1 0 0 1 1 1 0 mRNA capping enzyme NodS PF05401.11 ELR11755.1 - 0.094 12.3 0.0 0.18 11.4 0.0 1.4 1 0 0 1 1 1 0 Nodulation protein S (NodS) MPP6 PF10175.9 ELR11756.1 - 2.7 8.5 12.3 9 6.8 12.3 1.8 1 0 0 1 1 1 0 M-phase phosphoprotein 6 DUF4746 PF15928.5 ELR11756.1 - 6.9 6.0 7.7 17 4.7 7.7 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) PseudoU_synth_2 PF00849.22 ELR11757.1 - 2.2e-10 40.9 0.0 5e-09 36.4 0.0 2.2 1 1 0 1 1 1 1 RNA pseudouridylate synthase S4 PF01479.25 ELR11757.1 - 0.00017 21.2 0.0 0.00045 19.9 0.0 1.7 1 0 0 1 1 1 1 S4 domain DNA_pol_phi PF04931.13 ELR11757.1 - 0.0043 15.2 13.9 0.0056 14.9 13.9 1.1 1 0 0 1 1 1 1 DNA polymerase phi ACC_epsilon PF13822.6 ELR11757.1 - 0.041 14.6 1.8 0.12 13.1 1.8 1.7 1 0 0 1 1 1 0 Acyl-CoA carboxylase epsilon subunit RXT2_N PF08595.11 ELR11757.1 - 1.5 8.8 4.7 3.2 7.8 4.7 1.5 1 0 0 1 1 1 0 RXT2-like, N-terminal DUF5054 PF16477.5 ELR11759.1 - 1.7e-35 123.2 0.1 3.3e-34 119.0 0.1 2.4 1 1 0 1 1 1 1 Domain of unknown function (DUF5054) CLU PF13236.6 ELR11760.1 - 5.8e-42 144.0 0.0 1.1e-40 139.8 0.0 2.6 2 1 0 2 2 2 1 Clustered mitochondria eIF3_p135 PF12807.7 ELR11760.1 - 1.8e-14 54.2 0.2 1.2e-13 51.5 0.1 2.2 1 1 1 2 2 2 1 Translation initiation factor eIF3 subunit 135 TOM20_plant PF06552.12 ELR11760.1 - 0.056 13.2 0.0 0.13 12.0 0.0 1.6 1 0 0 1 1 1 0 Plant specific mitochondrial import receptor subunit TOM20 SR-25 PF10500.9 ELR11760.1 - 0.17 11.5 6.8 0.52 9.9 6.2 2.0 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein GREB1 PF15782.5 ELR11761.1 - 0.0032 14.7 14.2 0.0039 14.4 14.2 1.1 1 0 0 1 1 1 1 Gene regulated by oestrogen in breast cancer BSP_II PF05432.11 ELR11761.1 - 0.0052 16.5 17.2 0.0081 15.9 17.2 1.3 1 0 0 1 1 1 1 Bone sialoprotein II (BSP-II) PBP1_TM PF14812.6 ELR11761.1 - 0.053 13.9 11.2 0.14 12.5 11.2 1.7 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Sporozoite_P67 PF05642.11 ELR11761.1 - 0.24 9.4 10.9 0.36 8.8 10.9 1.2 1 0 0 1 1 1 0 Sporozoite P67 surface antigen TMCO5 PF14992.6 ELR11761.1 - 0.37 10.3 17.9 0.086 12.4 13.1 2.0 2 0 0 2 2 2 0 TMCO5 family TLP-20 PF06088.11 ELR11761.1 - 0.71 9.7 14.3 0.013 15.4 3.9 2.3 2 0 0 2 2 2 0 Nucleopolyhedrovirus telokin-like protein-20 (TLP20) ALG3 PF05208.13 ELR11762.1 - 0.045 13.2 0.5 0.046 13.1 0.5 1.0 1 0 0 1 1 1 0 ALG3 protein Fer4_23 PF18009.1 ELR11765.1 - 0.029 14.8 0.1 1.9 9.0 0.0 2.7 3 0 0 3 3 3 0 4Fe-4S iron-sulfur cluster binding domain MORN_2 PF07661.13 ELR11766.1 - 3.4e-07 29.7 0.0 0.025 14.8 0.0 4.4 4 0 0 4 4 4 3 MORN repeat variant MORN PF02493.20 ELR11766.1 - 0.026 14.4 1.6 3.9 7.5 0.2 4.0 4 0 0 4 4 4 0 MORN repeat EF-hand_1 PF00036.32 ELR11767.1 - 3.1e-14 51.4 0.0 0.0033 16.8 0.0 4.1 4 1 1 5 5 5 3 EF hand EF-hand_6 PF13405.6 ELR11767.1 - 4e-14 51.3 0.1 0.00087 19.0 0.0 4.3 5 0 0 5 5 5 3 EF-hand domain EF-hand_7 PF13499.6 ELR11767.1 - 3.7e-13 49.7 0.0 3.4e-06 27.4 0.0 3.2 2 2 1 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.6 ELR11767.1 - 4.1e-09 35.5 1.5 0.00055 19.3 0.0 3.3 4 0 0 4 4 4 2 EF hand EF-hand_8 PF13833.6 ELR11767.1 - 1.7e-08 34.2 0.0 0.12 12.3 0.0 3.4 2 1 1 3 3 3 3 EF-hand domain pair Ammonium_transp PF00909.21 ELR11768.1 - 4.5e-97 325.3 27.5 5.3e-97 325.0 27.5 1.0 1 0 0 1 1 1 1 Ammonium Transporter Family Ammonium_transp PF00909.21 ELR11769.1 - 4.9e-89 298.8 31.8 4e-59 200.3 18.6 2.9 2 1 0 2 2 2 2 Ammonium Transporter Family zf-RING_2 PF13639.6 ELR11770.1 - 1.5e-10 41.2 8.5 2.5e-10 40.5 8.5 1.4 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.7 ELR11770.1 - 8.1e-08 32.4 8.3 2.3e-07 31.0 8.3 1.7 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_3 PF13920.6 ELR11770.1 - 9.8e-08 31.7 4.9 1.7e-07 31.0 4.9 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 ELR11770.1 - 1.3e-07 31.4 7.1 2.7e-07 30.4 7.1 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 ELR11770.1 - 7.6e-07 28.9 7.9 1.5e-06 28.0 7.9 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 ELR11770.1 - 7.1e-06 25.9 2.9 7.1e-06 25.9 2.9 1.8 1 1 1 2 2 2 1 RING-type zinc-finger Prok-RING_4 PF14447.6 ELR11770.1 - 2.7e-05 24.0 5.6 4.6e-05 23.2 5.6 1.3 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 ELR11770.1 - 4.5e-05 23.3 6.7 8e-05 22.5 6.7 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-ANAPC11 PF12861.7 ELR11770.1 - 0.00047 20.2 5.1 0.0017 18.4 5.2 1.9 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger Zn_ribbon_17 PF17120.5 ELR11770.1 - 0.0057 16.2 4.5 0.013 15.1 4.5 1.5 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type zf-RING-like PF08746.11 ELR11770.1 - 0.014 15.7 6.9 0.025 14.9 6.9 1.4 1 0 0 1 1 1 0 RING-like domain zf-C3HC4_4 PF15227.6 ELR11770.1 - 0.075 13.2 4.6 0.16 12.1 4.6 1.6 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING DUF1218 PF06749.12 ELR11770.1 - 0.38 11.3 0.1 0.38 11.3 0.1 3.0 4 0 0 4 4 4 0 Protein of unknown function (DUF1218) zf-RING_11 PF17123.5 ELR11770.1 - 0.68 9.7 9.6 0.054 13.3 4.3 1.9 2 0 0 2 2 2 0 RING-like zinc finger RINGv PF12906.7 ELR11770.1 - 6.3 7.0 7.8 14 5.9 7.8 1.6 1 0 0 1 1 1 0 RING-variant domain Sid-5 PF17204.3 ELR11770.1 - 9.8 6.4 6.3 2.2 8.5 1.2 2.6 1 1 1 2 2 2 0 Sid-5 family Aldedh PF00171.22 ELR11771.1 - 1e-131 439.7 0.0 1.2e-131 439.5 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family LuxC PF05893.14 ELR11771.1 - 0.0053 15.9 0.3 0.12 11.4 0.0 2.1 1 1 1 2 2 2 2 Acyl-CoA reductase (LuxC) Pkinase_Tyr PF07714.17 ELR11772.1 - 9.2e-45 152.9 0.0 1.7e-44 152.1 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ELR11772.1 - 1.8e-41 142.3 0.0 3.2e-41 141.5 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.23 ELR11772.1 - 0.027 14.4 2.3 0.15 12.0 0.1 2.7 2 1 1 3 3 3 0 Phosphotransferase enzyme family Myosin_head PF00063.21 ELR11773.1 - 8.8e-246 817.4 0.2 1.4e-245 816.6 0.2 1.4 1 0 0 1 1 1 1 Myosin head (motor domain) Myosin_TH1 PF06017.13 ELR11773.1 - 8.3e-30 103.9 0.1 1.5e-29 103.0 0.1 1.4 1 0 0 1 1 1 1 Unconventional myosin tail, actin- and lipid-binding SH3_2 PF07653.17 ELR11773.1 - 8.4e-11 41.4 0.0 4.1e-10 39.2 0.0 2.2 2 0 0 2 2 2 1 Variant SH3 domain SH3_1 PF00018.28 ELR11773.1 - 2.7e-09 36.5 0.0 6.5e-09 35.3 0.0 1.7 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 ELR11773.1 - 4.2e-09 36.1 0.0 2.1e-08 33.9 0.0 2.2 2 0 0 2 2 2 1 Variant SH3 domain 30K_MP_core PF17644.1 ELR11773.1 - 0.088 12.7 0.0 0.24 11.3 0.0 1.7 1 0 0 1 1 1 0 Core domain of 30K viral movement proteins Cofilin_ADF PF00241.20 ELR11774.1 - 4.6e-11 42.6 0.0 5.2e-11 42.4 0.0 1.0 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein DUF4177 PF13783.6 ELR11774.1 - 0.066 13.5 0.0 0.12 12.7 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4177) Glycos_transf_1 PF00534.20 ELR11775.1 - 1.2e-19 70.5 0.0 3.2e-19 69.1 0.0 1.6 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 ELR11775.1 - 1.2e-15 58.1 0.4 1.2e-14 54.9 0.1 2.1 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 ELR11775.1 - 2.7e-06 27.5 1.9 4.1e-05 23.7 0.3 2.3 2 0 0 2 2 2 1 Glycosyltransferase Family 4 Glyco_trans_4_4 PF13579.6 ELR11775.1 - 0.0005 20.6 5.3 0.021 15.2 0.7 2.7 2 1 0 2 2 2 2 Glycosyl transferase 4-like domain PsbJ PF01788.17 ELR11776.1 - 0.075 12.9 1.4 0.2 11.6 1.4 1.8 1 0 0 1 1 1 0 PsbJ LRR_4 PF12799.7 ELR11777.1 - 1.4e-22 79.4 51.9 5.3e-08 33.0 4.1 7.1 5 1 2 7 7 7 5 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 ELR11777.1 - 6.6e-13 48.2 47.9 2.9e-06 26.9 12.7 5.7 2 1 5 7 7 7 7 Leucine rich repeat LRR_1 PF00560.33 ELR11777.1 - 3.7e-06 26.7 33.5 0.36 11.6 0.3 9.0 8 1 0 8 8 8 2 Leucine Rich Repeat SKG6 PF08693.10 ELR11777.1 - 0.001 18.4 10.4 0.003 16.9 10.4 1.8 1 0 0 1 1 1 1 Transmembrane alpha-helix domain LRR_6 PF13516.6 ELR11777.1 - 0.0034 17.3 47.3 0.89 9.8 0.1 8.6 9 0 0 9 9 9 6 Leucine Rich repeat LRRNT_2 PF08263.12 ELR11777.1 - 0.004 17.4 1.9 0.011 16.0 1.9 1.8 1 0 0 1 1 1 1 Leucine rich repeat N-terminal domain DUF4448 PF14610.6 ELR11777.1 - 0.17 11.7 0.1 0.3 10.8 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4448) DUF3827 PF12877.7 ELR11777.1 - 0.39 9.0 0.7 0.57 8.5 0.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3827) Gar1 PF04410.14 ELR11778.1 - 3.9e-30 104.7 0.0 4.7e-30 104.4 0.0 1.0 1 0 0 1 1 1 1 Gar1/Naf1 RNA binding region G-patch PF01585.23 ELR11779.1 - 1.9e-06 27.6 0.5 1.9e-06 27.6 0.5 2.0 2 0 0 2 2 2 1 G-patch domain G-patch_2 PF12656.7 ELR11779.1 - 0.00026 21.0 0.4 0.00026 21.0 0.4 2.8 3 0 0 3 3 3 1 G-patch domain SR-25 PF10500.9 ELR11779.1 - 0.08 12.5 10.9 0.23 11.0 10.9 1.7 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein DUF3123 PF11321.8 ELR11779.1 - 0.082 13.6 2.4 0.64 10.7 0.6 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3123) Smg4_UPF3 PF03467.15 ELR11779.1 - 0.083 12.9 0.0 0.21 11.6 0.0 1.6 1 0 0 1 1 1 0 Smg-4/UPF3 family DUF3446 PF11928.8 ELR11779.1 - 0.77 10.1 12.5 1.9 8.9 12.5 1.6 1 0 0 1 1 1 0 Early growth response N-terminal domain IMUP PF15761.5 ELR11779.1 - 0.84 10.4 11.3 0.31 11.8 7.0 2.5 2 0 0 2 2 2 0 Immortalisation up-regulated protein DENN PF02141.21 ELR11780.1 - 1.5e-50 171.8 4.5 2.6e-50 171.0 4.5 1.4 1 0 0 1 1 1 1 DENN (AEX-3) domain WD40 PF00400.32 ELR11780.1 - 1.6e-40 136.3 26.5 3.2e-06 27.8 0.4 8.5 8 0 0 8 8 8 6 WD domain, G-beta repeat uDENN PF03456.18 ELR11780.1 - 7.6e-17 61.8 0.3 1.7e-16 60.7 0.3 1.7 1 0 0 1 1 1 1 uDENN domain SBF2 PF12335.8 ELR11780.1 - 3.5e-16 59.5 3.8 5.3e-10 39.3 0.1 3.5 2 1 1 3 3 3 3 Myotubularin protein Nup160 PF11715.8 ELR11780.1 - 0.0021 16.8 5.3 1.1 7.8 0.1 4.0 3 2 0 4 4 4 2 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ELR11780.1 - 0.0069 16.7 0.2 0.75 10.1 0.0 3.2 3 0 0 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain dDENN PF03455.19 ELR11780.1 - 0.0079 16.2 3.2 0.03 14.3 0.6 3.0 3 0 0 3 3 3 1 dDENN domain HJURP_C PF12347.8 ELR11780.1 - 0.021 14.9 0.6 0.91 9.6 0.1 2.6 2 0 0 2 2 2 0 Holliday junction regulator protein family C-terminal repeat Cep57_CLD_2 PF14197.6 ELR11780.1 - 0.16 12.1 3.0 13 5.9 0.2 2.5 2 0 0 2 2 2 0 Centrosome localisation domain of PPC89 Rootletin PF15035.6 ELR11780.1 - 0.23 11.5 3.5 12 5.9 0.3 2.6 2 0 0 2 2 2 0 Ciliary rootlet component, centrosome cohesion Cyto_heme_lyase PF01265.17 ELR11780.1 - 0.52 9.9 2.3 0.39 10.3 0.2 1.8 2 0 0 2 2 2 0 Cytochrome c/c1 heme lyase Ring_hydroxyl_A PF00848.19 ELR11781.1 - 6.1e-26 91.7 4.6 1.3e-25 90.7 1.4 2.7 2 2 0 2 2 2 1 Ring hydroxylating alpha subunit (catalytic domain) Rieske PF00355.26 ELR11781.1 - 1.5e-18 66.5 0.1 2.7e-18 65.7 0.1 1.4 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain WD40 PF00400.32 ELR11782.1 - 1.7e-24 85.6 13.1 3.4e-10 40.3 0.4 7.1 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ELR11782.1 - 7.6e-07 29.3 0.9 0.072 13.4 0.1 4.0 3 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Dynactin_p62 PF05502.13 ELR11782.1 - 0.014 14.2 2.4 0.017 13.9 2.4 1.1 1 0 0 1 1 1 0 Dynactin p62 family TAF4 PF05236.14 ELR11782.1 - 0.02 14.7 17.4 0.029 14.1 17.4 1.2 1 0 0 1 1 1 0 Transcription initiation factor TFIID component TAF4 family Vfa1 PF08432.10 ELR11782.1 - 0.25 11.7 18.8 0.41 11.0 18.8 1.4 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 NARP1 PF12569.8 ELR11782.1 - 0.3 9.9 16.3 0.46 9.3 16.3 1.3 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 PTPRCAP PF15713.5 ELR11782.1 - 0.43 10.9 17.3 0.76 10.1 17.3 1.4 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated Atg14 PF10186.9 ELR11782.1 - 2.6 7.0 15.5 4 6.4 15.5 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF3138 PF11336.8 ELR11782.1 - 2.8 6.5 12.1 4.1 5.9 12.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) U79_P34 PF03064.16 ELR11782.1 - 3.5 6.9 20.6 6.1 6.1 20.6 1.3 1 0 0 1 1 1 0 HSV U79 / HCMV P34 CDC45 PF02724.14 ELR11782.1 - 5.4 5.2 17.3 7.4 4.7 17.3 1.1 1 0 0 1 1 1 0 CDC45-like protein Rtf2 PF04641.12 ELR11782.1 - 5.7 6.2 21.2 8.5 5.6 21.2 1.2 1 0 0 1 1 1 0 Rtf2 RING-finger XRN_M PF17846.1 ELR11782.1 - 6.5 5.6 11.8 9.2 5.1 11.8 1.1 1 0 0 1 1 1 0 Xrn1 helical domain MMR1 PF08505.10 ELR11782.1 - 7.7 6.7 14.1 12 6.1 14.1 1.2 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein RasGEF PF00617.19 ELR11783.1 - 1.6e-101 337.9 1.8 1.7e-62 210.7 1.4 2.5 2 0 0 2 2 2 2 RasGEF domain RCC1 PF00415.18 ELR11783.1 - 6.2e-56 186.8 20.3 7.3e-13 48.9 0.1 6.6 6 0 0 6 6 6 6 Regulator of chromosome condensation (RCC1) repeat RasGEF_N PF00618.20 ELR11783.1 - 1.2e-51 173.3 0.7 3.8e-26 91.4 0.0 3.0 2 0 0 2 2 2 2 RasGEF N-terminal motif RCC1_2 PF13540.6 ELR11783.1 - 1.7e-20 72.3 26.5 8.8e-05 22.2 1.2 5.6 5 0 0 5 5 5 5 Regulator of chromosome condensation (RCC1) repeat MRI PF15325.6 ELR11783.1 - 0.016 16.3 0.4 0.016 16.3 0.4 4.9 4 1 1 5 5 5 0 Modulator of retrovirus infection MMS19_N PF14500.6 ELR11783.1 - 0.1 12.1 0.0 0.57 9.7 0.0 2.1 2 0 0 2 2 2 0 Dos2-interacting transcription regulator of RNA-Pol-II Arf PF00025.21 ELR11784.1 - 1.7e-51 174.1 0.1 5.5e-51 172.5 0.1 1.6 1 1 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 ELR11784.1 - 6.6e-10 39.2 0.1 8.9e-10 38.8 0.1 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Gtr1_RagA PF04670.12 ELR11784.1 - 2.1e-07 30.5 0.1 2.7e-07 30.2 0.1 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Ras PF00071.22 ELR11784.1 - 7e-07 29.0 0.1 9.8e-07 28.5 0.1 1.4 1 1 0 1 1 1 1 Ras family SRPRB PF09439.10 ELR11784.1 - 2.8e-06 26.9 0.1 4.6e-06 26.2 0.1 1.3 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.20 ELR11784.1 - 2.1e-05 23.9 1.8 0.0093 15.2 0.3 2.3 1 1 1 2 2 2 2 G-protein alpha subunit MMR_HSR1 PF01926.23 ELR11784.1 - 7.2e-05 22.8 0.1 0.0001 22.3 0.1 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase Cas_Cas2CT1978 PF09707.10 ELR11784.1 - 0.056 13.5 0.0 0.12 12.5 0.0 1.5 1 0 0 1 1 1 0 CRISPR-associated protein (Cas_Cas2CT1978) 6PF2K PF01591.18 ELR11784.1 - 0.06 12.6 0.0 0.075 12.3 0.0 1.1 1 0 0 1 1 1 0 6-phosphofructo-2-kinase Ceramidase_alk PF04734.13 ELR11785.1 - 1.4e-22 80.1 0.0 2.5e-14 52.8 0.0 2.4 2 1 0 2 2 2 2 Neutral/alkaline non-lysosomal ceramidase, N-terminal Ank_5 PF13857.6 ELR11786.1 - 1.9e-19 69.5 0.2 7.8e-10 38.8 0.0 2.5 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.30 ELR11786.1 - 5.2e-16 58.3 0.1 3e-07 30.6 0.1 3.1 3 0 0 3 3 3 2 Ankyrin repeat Ank_2 PF12796.7 ELR11786.1 - 1.5e-15 57.5 0.1 3.2e-15 56.5 0.1 1.5 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ELR11786.1 - 4.2e-15 55.9 0.1 1.6e-08 34.9 0.0 2.4 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 ELR11786.1 - 1.3e-09 37.5 0.0 1.1e-05 25.4 0.0 2.8 3 0 0 3 3 3 2 Ankyrin repeat Pkinase_Tyr PF07714.17 ELR11787.1 - 3.2e-64 216.7 0.0 4.3e-64 216.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ELR11787.1 - 3.3e-47 161.1 0.0 4.8e-47 160.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_fungal PF17667.1 ELR11787.1 - 0.0013 17.6 4.4 0.005 15.7 0.1 2.1 2 0 0 2 2 2 1 Fungal protein kinase Haspin_kinase PF12330.8 ELR11787.1 - 0.0068 15.4 0.0 0.013 14.5 0.0 1.3 1 0 0 1 1 1 1 Haspin like kinase domain FTA2 PF13095.6 ELR11787.1 - 0.081 12.5 0.0 7.7 6.1 0.0 2.3 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Herpes_U47 PF05467.11 ELR11787.1 - 0.2 9.7 1.2 0.3 9.2 1.2 1.1 1 0 0 1 1 1 0 Herpesvirus glycoprotein U47 PQQ_3 PF13570.6 ELR11787.1 - 0.49 11.0 2.3 3.2 8.4 0.1 3.5 4 0 0 4 4 4 0 PQQ-like domain DUF2970 PF11174.8 ELR11787.1 - 2.6 8.0 5.7 8.5 6.3 5.5 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2970) PH PF00169.29 ELR11790.1 - 5.7e-19 68.6 4.3 1.2e-14 54.7 0.1 3.5 3 0 0 3 3 3 2 PH domain Patatin PF01734.22 ELR11790.1 - 5.2e-14 52.9 0.0 3.8e-13 50.1 0.0 2.4 1 1 0 1 1 1 1 Patatin-like phospholipase PH_11 PF15413.6 ELR11790.1 - 6.6e-07 29.7 12.9 0.013 15.9 2.8 4.4 3 1 0 3 3 3 2 Pleckstrin homology domain Bacillus_HBL PF05791.11 ELR11790.1 - 0.023 14.5 5.2 0.044 13.6 5.2 1.3 1 0 0 1 1 1 0 Bacillus haemolytic enterotoxin (HBL) PH_8 PF15409.6 ELR11790.1 - 0.051 13.9 0.3 0.2 12.0 0.3 2.1 1 1 0 1 1 1 0 Pleckstrin homology domain Apolipoprotein PF01442.18 ELR11790.1 - 0.055 13.3 0.3 0.094 12.6 0.3 1.3 1 0 0 1 1 1 0 Apolipoprotein A1/A4/E domain DUF1664 PF07889.12 ELR11790.1 - 0.097 12.7 5.6 0.2 11.7 5.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) HIP1_clath_bdg PF16515.5 ELR11790.1 - 0.12 13.0 1.8 0.35 11.5 1.8 1.7 1 0 0 1 1 1 0 Clathrin-binding domain of Huntingtin-interacting protein 1 LPP PF04728.13 ELR11790.1 - 0.16 12.4 2.0 0.21 12.0 0.1 2.1 2 0 0 2 2 2 0 Lipoprotein leucine-zipper Roughex PF06020.11 ELR11790.1 - 0.25 10.4 1.0 0.58 9.2 1.0 1.5 1 0 0 1 1 1 0 Drosophila roughex protein Seryl_tRNA_N PF02403.22 ELR11790.1 - 0.3 11.3 11.3 0.74 10.1 11.3 1.6 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain GCN5L1 PF06320.13 ELR11790.1 - 0.39 10.9 6.3 0.77 9.9 6.3 1.4 1 0 0 1 1 1 0 GCN5-like protein 1 (GCN5L1) AAA_13 PF13166.6 ELR11790.1 - 3.8 6.0 9.1 6.1 5.4 9.1 1.2 1 0 0 1 1 1 0 AAA domain ISG65-75 PF11727.8 ELR11790.1 - 4.1 6.5 12.1 8 5.6 12.1 1.4 1 0 0 1 1 1 0 Invariant surface glycoprotein Cofilin_ADF PF00241.20 ELR11791.1 - 4.8e-29 100.6 0.0 7.2e-10 38.7 0.0 3.2 3 0 0 3 3 3 3 Cofilin/tropomyosin-type actin-binding protein Pkinase_Tyr PF07714.17 ELR11792.1 - 8.3e-128 425.1 0.0 3.5e-63 213.3 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 ELR11792.1 - 1.5e-112 375.2 0.0 1e-56 192.3 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain 5_nucleotid_C PF02872.18 ELR11792.1 - 1.4e-26 93.6 0.0 2.9e-26 92.6 0.0 1.5 1 0 0 1 1 1 1 5'-nucleotidase, C-terminal domain Guanylate_cyc PF00211.20 ELR11792.1 - 1.2e-12 47.9 0.0 2.6e-12 46.8 0.0 1.5 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain Kdo PF06293.14 ELR11792.1 - 3.9e-08 32.9 0.7 0.0044 16.4 0.2 2.3 2 0 0 2 2 2 2 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 ELR11792.1 - 6.6e-08 31.9 1.0 0.0001 21.4 0.2 2.5 3 0 0 3 3 3 2 Haspin like kinase domain FTA2 PF13095.6 ELR11792.1 - 7.9e-07 28.9 0.1 1.5 8.4 0.0 4.2 3 1 1 4 4 4 2 Kinetochore Sim4 complex subunit FTA2 APH PF01636.23 ELR11792.1 - 2.3e-06 27.7 0.0 0.002 18.1 0.0 2.7 2 0 0 2 2 2 2 Phosphotransferase enzyme family Kinase-like PF14531.6 ELR11792.1 - 2.6e-06 27.0 0.0 0.069 12.5 0.0 2.4 2 0 0 2 2 2 2 Kinase-like RIO1 PF01163.22 ELR11792.1 - 3.3e-05 23.6 0.9 0.023 14.3 0.2 2.3 2 0 0 2 2 2 2 RIO1 family ABC1 PF03109.16 ELR11792.1 - 0.00082 19.5 0.0 0.026 14.7 0.0 2.4 2 0 0 2 2 2 1 ABC1 family EGF_2 PF07974.13 ELR11792.1 - 0.0021 18.4 9.0 0.0042 17.4 9.0 1.5 1 0 0 1 1 1 1 EGF-like domain Pkinase_fungal PF17667.1 ELR11792.1 - 0.0032 16.3 0.0 0.12 11.1 0.0 2.2 2 0 0 2 2 2 1 Fungal protein kinase EGF PF00008.27 ELR11792.1 - 0.041 14.2 2.8 0.096 13.0 2.8 1.6 1 0 0 1 1 1 0 EGF-like domain EB PF01683.18 ELR11792.1 - 0.094 13.0 3.3 0.26 11.6 3.3 1.6 1 0 0 1 1 1 0 EB module hEGF PF12661.7 ELR11792.1 - 0.19 12.4 7.8 0.44 11.3 7.8 1.7 1 0 0 1 1 1 0 Human growth factor-like EGF Peptidase_C39_2 PF13529.6 ELR11793.1 - 5e-08 33.6 0.0 1.2e-07 32.4 0.0 1.6 1 1 0 1 1 1 1 Peptidase_C39 like family Peptidase_C70 PF12385.8 ELR11793.1 - 4.4e-05 23.5 0.0 0.00072 19.6 0.0 2.3 1 1 0 1 1 1 1 Papain-like cysteine protease AvrRpt2 Guanylate_cyc_2 PF09778.9 ELR11793.1 - 0.12 11.7 0.0 2.4 7.5 0.0 2.6 3 0 0 3 3 3 0 Guanylylate cyclase PARG_cat PF05028.14 ELR11794.1 - 5.5e-10 39.0 0.0 7.8e-10 38.6 0.0 1.2 1 0 0 1 1 1 1 Poly (ADP-ribose) glycohydrolase (PARG) Ras PF00071.22 ELR11795.1 - 2.8e-47 160.3 0.0 3.4e-47 160.1 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR11795.1 - 2.4e-24 85.8 0.0 3.5e-24 85.3 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR11795.1 - 1.4e-07 31.2 0.0 1.8e-07 30.8 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 ELR11795.1 - 0.023 14.8 0.0 0.037 14.1 0.0 1.4 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_7 PF12775.7 ELR11795.1 - 0.11 12.0 0.0 0.17 11.3 0.0 1.2 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_16 PF13191.6 ELR11795.1 - 0.16 12.4 0.0 0.29 11.5 0.0 1.4 1 1 0 1 1 1 0 AAA ATPase domain ADH_zinc_N PF00107.26 ELR11796.1 - 7.1e-23 81.0 0.0 1.5e-22 80.0 0.0 1.5 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 ELR11796.1 - 7.1e-18 65.9 0.0 1.6e-17 64.8 0.0 1.6 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_N PF08240.12 ELR11796.1 - 1.2e-08 34.8 0.0 2.9e-08 33.5 0.0 1.6 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain PALP PF00291.25 ELR11796.1 - 0.014 14.8 0.3 0.019 14.4 0.3 1.2 1 0 0 1 1 1 0 Pyridoxal-phosphate dependent enzyme TrkA_N PF02254.18 ELR11796.1 - 0.1 12.8 0.2 0.17 12.2 0.2 1.3 1 0 0 1 1 1 0 TrkA-N domain Oxidored_q3 PF00499.20 ELR11798.1 - 0.019 14.7 1.0 0.021 14.5 1.0 1.2 1 0 0 1 1 1 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 VWA_3 PF13768.6 ELR11799.1 - 2.1e-34 118.7 0.0 3.6e-34 118.0 0.0 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.28 ELR11799.1 - 3.8e-16 59.8 0.0 6.6e-16 59.1 0.0 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.6 ELR11799.1 - 3.8e-15 56.5 0.0 7.2e-15 55.6 0.0 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain VIT PF08487.10 ELR11799.1 - 1.4e-09 38.1 0.0 4e-09 36.7 0.0 1.8 1 0 0 1 1 1 1 Vault protein inter-alpha-trypsin domain VWA_CoxE PF05762.14 ELR11799.1 - 0.0004 19.8 0.0 0.0048 16.3 0.0 2.2 1 1 1 2 2 2 1 VWA domain containing CoxE-like protein Phage_integrase PF00589.22 ELR11800.1 - 5.6e-09 36.0 0.0 8.1e-09 35.5 0.0 1.3 1 1 0 1 1 1 1 Phage integrase family RT_RNaseH PF17917.1 ELR11801.1 - 0.0012 19.2 0.0 0.0059 16.9 0.0 2.0 1 1 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 ELR11801.1 - 0.0069 16.4 0.0 0.039 14.0 0.0 2.1 1 1 0 1 1 1 1 RNase H-like domain found in reverse transcriptase eIF3g PF12353.8 ELR11803.1 - 0.00012 22.5 2.7 0.00025 21.4 2.7 1.6 1 1 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit G Ribosomal_60s PF00428.19 ELR11803.1 - 0.032 14.8 0.7 0.032 14.8 0.7 1.9 2 0 0 2 2 2 0 60s Acidic ribosomal protein CENP-B_dimeris PF09026.10 ELR11803.1 - 2.5 8.5 7.5 7.2 7.1 7.5 1.7 1 0 0 1 1 1 0 Centromere protein B dimerisation domain adh_short PF00106.25 ELR11804.1 - 4.7e-25 88.2 0.9 5e-20 71.8 0.3 2.7 2 1 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 ELR11804.1 - 2.1e-17 63.4 1.1 1.4e-12 47.7 0.3 2.6 2 1 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ELR11804.1 - 0.00013 21.9 0.1 0.00027 20.9 0.1 1.7 1 1 0 1 1 1 1 KR domain CcmH PF03918.14 ELR11806.1 - 0.028 13.7 0.0 0.054 12.8 0.0 1.4 1 0 0 1 1 1 0 Cytochrome C biogenesis protein Ank_4 PF13637.6 ELR11808.1 - 2.1e-08 34.5 11.2 0.035 14.7 0.1 6.7 4 3 2 6 6 6 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 ELR11808.1 - 6e-08 33.2 2.1 0.016 15.7 0.1 3.8 1 1 3 4 4 4 3 Ankyrin repeats (3 copies) Ank_5 PF13857.6 ELR11808.1 - 0.00021 21.5 6.8 11 6.5 0.0 5.8 5 2 1 6 6 6 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 ELR11808.1 - 0.076 13.6 4.5 2.5e+02 2.8 0.0 6.0 7 0 0 7 7 7 0 Ankyrin repeat Anophelin PF10731.9 ELR11809.1 - 0.3 11.0 6.8 0.89 9.4 6.8 1.8 1 0 0 1 1 1 0 Thrombin inhibitor from mosquito Astro_capsid_p PF12226.8 ELR11809.1 - 6.2 5.9 6.7 11 5.0 6.7 1.3 1 0 0 1 1 1 0 Turkey astrovirus capsid protein TMEM65 PF10507.9 ELR11810.1 - 0.085 12.8 9.3 2.3 8.2 1.1 2.9 1 1 1 2 2 2 0 Transmembrane protein 65 Pkinase_Tyr PF07714.17 ELR11811.1 - 3.5e-58 196.9 0.0 4.5e-58 196.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ELR11811.1 - 3e-49 167.8 0.0 4e-49 167.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_fungal PF17667.1 ELR11811.1 - 8.5e-05 21.5 0.0 0.00013 20.8 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase ABC1 PF03109.16 ELR11811.1 - 0.011 15.9 0.0 0.019 15.2 0.0 1.3 1 0 0 1 1 1 0 ABC1 family Kdo PF06293.14 ELR11811.1 - 0.074 12.4 0.1 0.13 11.6 0.1 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DUF1678 PF07913.11 ELR11811.1 - 0.097 12.4 0.1 0.53 10.0 0.1 2.0 3 0 0 3 3 3 0 Protein of unknown function (DUF1678) Capsid_N PF16903.5 ELR11814.1 - 1.4e-12 47.7 0.0 1.7e-06 27.8 0.0 2.2 2 0 0 2 2 2 2 Major capsid protein N-terminus Capsid_NCLDV PF04451.12 ELR11814.1 - 1.3e-06 28.3 0.0 2.2e-06 27.6 0.0 1.3 1 0 0 1 1 1 1 Large eukaryotic DNA virus major capsid protein HTH_Tnp_ISL3 PF13542.6 ELR11815.1 - 0.11 11.9 0.0 0.25 10.8 0.0 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain of transposase family ISL3 Importin_rep_4 PF18808.1 ELR11815.1 - 0.29 11.4 1.7 0.33 11.3 0.5 1.6 1 1 0 1 1 1 0 Importin repeat INSC_LBD PF16748.5 ELR11820.1 - 0.014 14.9 0.1 0.38 10.2 0.0 2.3 2 0 0 2 2 2 0 Inscuteable LGN-binding domain DUF3155 PF11352.8 ELR11821.1 - 0.16 12.4 0.2 0.32 11.4 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3155) F-box PF00646.33 ELR11822.1 - 3.9e-06 26.6 0.6 3.9e-06 26.6 0.6 2.2 2 0 0 2 2 2 1 F-box domain F-box-like PF12937.7 ELR11822.1 - 9.2e-06 25.5 2.8 1.2e-05 25.1 0.9 2.2 2 0 0 2 2 2 1 F-box-like DUF952 PF06108.12 ELR11823.1 - 0.15 12.0 0.0 0.39 10.8 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF952) SWIM PF04434.17 ELR11826.1 - 0.1 12.3 0.2 0.1 12.3 0.2 2.0 1 1 1 2 2 2 0 SWIM zinc finger HHA PF05321.11 ELR11828.1 - 0.044 14.1 0.4 15 5.9 0.1 3.3 2 1 1 3 3 3 0 Haemolysin expression modulating protein NOA36 PF06524.12 ELR11828.1 - 0.87 8.9 12.0 0.39 10.0 6.9 2.1 2 0 0 2 2 2 0 NOA36 protein CENP-B_dimeris PF09026.10 ELR11828.1 - 6.4 7.2 15.8 12 6.3 15.8 1.4 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Kelch_1 PF01344.25 ELR11831.1 - 2e-17 62.5 5.1 1.4e-05 24.5 0.0 6.0 6 0 0 6 6 6 4 Kelch motif Kelch_6 PF13964.6 ELR11831.1 - 7.3e-15 54.6 7.7 0.0065 16.7 0.1 5.9 5 1 1 6 6 6 4 Kelch motif Kelch_4 PF13418.6 ELR11831.1 - 5.9e-09 35.8 13.7 0.0033 17.4 1.6 5.2 5 1 1 6 6 6 3 Galactose oxidase, central domain Kelch_2 PF07646.15 ELR11831.1 - 1.3e-05 25.0 0.4 0.44 10.6 0.0 4.9 5 1 0 5 5 5 1 Kelch motif Kelch_3 PF13415.6 ELR11831.1 - 0.0016 18.7 1.0 0.0016 18.7 1.0 4.8 4 1 1 5 5 5 1 Galactose oxidase, central domain Kelch_5 PF13854.6 ELR11831.1 - 0.0036 17.3 2.9 3.7 7.7 0.1 4.5 4 0 0 4 4 4 1 Kelch motif DUF4454 PF14628.6 ELR11831.1 - 0.049 13.5 0.0 0.082 12.7 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4454) SLBB PF10531.9 ELR11831.1 - 0.072 13.0 0.3 4.6 7.2 0.0 3.1 3 0 0 3 3 3 0 SLBB domain DUF3678 PF12435.8 ELR11831.1 - 1.6 8.2 5.9 0.4 10.1 1.4 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3678) Apolipoprotein PF01442.18 ELR11832.1 - 0.17 11.7 0.9 0.28 11.0 0.9 1.3 1 0 0 1 1 1 0 Apolipoprotein A1/A4/E domain AAA_28 PF13521.6 ELR11836.1 - 4e-08 33.7 0.2 9.2e-08 32.5 0.2 1.6 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.6 ELR11836.1 - 0.00047 20.7 0.0 0.0011 19.5 0.0 1.5 1 1 0 1 1 1 1 AAA domain AAA PF00004.29 ELR11836.1 - 0.0009 19.7 0.0 0.0018 18.7 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) MeaB PF03308.16 ELR11836.1 - 0.0017 17.4 0.0 0.081 11.9 0.0 2.1 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_33 PF13671.6 ELR11836.1 - 0.0035 17.5 0.0 0.0065 16.6 0.0 1.3 1 1 0 1 1 1 1 AAA domain NB-ARC PF00931.22 ELR11836.1 - 0.0041 16.4 0.0 0.0057 15.9 0.0 1.3 1 0 0 1 1 1 1 NB-ARC domain AAA_16 PF13191.6 ELR11836.1 - 0.0042 17.5 0.0 0.0047 17.3 0.0 1.3 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 ELR11836.1 - 0.0086 16.4 0.0 0.013 15.7 0.0 1.4 1 1 0 1 1 1 1 AAA domain NTPase_1 PF03266.15 ELR11836.1 - 0.017 15.0 0.0 0.029 14.3 0.0 1.4 1 0 0 1 1 1 0 NTPase Glyco_hydro_42 PF02449.15 ELR11836.1 - 0.033 13.5 0.0 0.038 13.3 0.0 1.1 1 0 0 1 1 1 0 Beta-galactosidase NACHT PF05729.12 ELR11836.1 - 0.056 13.3 0.0 0.083 12.8 0.0 1.3 1 0 0 1 1 1 0 NACHT domain RuvB_N PF05496.12 ELR11836.1 - 0.072 12.8 0.0 0.12 12.1 0.0 1.3 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain RNA_helicase PF00910.22 ELR11836.1 - 0.097 13.1 0.0 0.2 12.0 0.0 1.6 1 0 0 1 1 1 0 RNA helicase AAA_17 PF13207.6 ELR11836.1 - 0.1 13.1 0.0 0.2 12.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain MobB PF03205.14 ELR11836.1 - 0.16 11.9 0.0 0.28 11.1 0.0 1.4 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B Nop14 PF04147.12 ELR11841.1 - 0.32 9.1 10.4 0.49 8.6 10.4 1.2 1 0 0 1 1 1 0 Nop14-like family TMEM135_C_rich PF15982.5 ELR11844.1 - 2e-05 25.2 1.4 0.0042 17.7 0.6 2.4 2 0 0 2 2 2 2 N-terminal cysteine-rich region of Transmembrane protein 135 VF530 PF09905.9 ELR11844.1 - 0.092 12.9 0.3 0.27 11.4 0.3 1.9 1 0 0 1 1 1 0 DNA-binding protein VF530 RasGAP PF00616.19 ELR11845.1 - 7.8e-23 81.3 0.0 1.1e-22 80.8 0.0 1.2 1 0 0 1 1 1 1 GTPase-activator protein for Ras-like GTPase Laminin_G_3 PF13385.6 ELR11845.1 - 2e-16 60.5 2.7 3e-15 56.7 0.1 2.6 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily DUF4381 PF14316.6 ELR11845.1 - 0.058 13.6 0.1 0.13 12.5 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) OSTbeta PF15048.6 ELR11845.1 - 0.079 13.1 0.1 0.17 12.0 0.1 1.5 1 0 0 1 1 1 0 Organic solute transporter subunit beta protein DUF3040 PF11239.8 ELR11845.1 - 1.1 9.6 0.0 1.1 9.6 0.0 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF3040) RasGEF PF00617.19 ELR11846.1 - 9.4e-42 143.2 1.1 2.3e-41 141.9 1.1 1.7 1 1 0 1 1 1 1 RasGEF domain RNA_capsid PF03035.14 ELR11846.1 - 0.24 11.4 4.9 0.41 10.6 4.9 1.3 1 0 0 1 1 1 0 Calicivirus putative RNA polymerase/capsid protein cobW PF02492.19 ELR11848.1 - 5.8e-17 61.8 0.2 5.4e-16 58.7 0.2 2.0 1 1 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain CobW_C PF07683.14 ELR11848.1 - 0.00015 21.6 0.1 0.0016 18.4 0.1 2.6 1 1 0 1 1 1 1 Cobalamin synthesis protein cobW C-terminal domain AAA_16 PF13191.6 ELR11848.1 - 0.0034 17.8 0.1 0.0067 16.8 0.1 1.5 1 0 0 1 1 1 1 AAA ATPase domain DUF2075 PF09848.9 ELR11848.1 - 0.078 12.2 0.1 0.16 11.2 0.1 1.5 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) Viral_helicase1 PF01443.18 ELR11848.1 - 0.1 12.3 0.0 0.19 11.4 0.0 1.4 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase TsaE PF02367.17 ELR11848.1 - 0.11 12.5 0.0 0.22 11.5 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE EF-hand_1 PF00036.32 ELR11849.1 - 2e-06 27.0 2.9 2.6e-06 26.6 0.1 2.4 3 0 0 3 3 3 1 EF hand EF-hand_8 PF13833.6 ELR11849.1 - 1.3e-05 24.9 1.8 5e-05 23.1 0.2 2.4 3 0 0 3 3 3 1 EF-hand domain pair EF-hand_5 PF13202.6 ELR11849.1 - 0.00014 21.2 0.4 0.00032 20.1 0.1 1.8 2 0 0 2 2 2 1 EF hand EF-hand_6 PF13405.6 ELR11849.1 - 0.00037 20.2 0.2 0.0012 18.6 0.0 1.9 2 0 0 2 2 2 1 EF-hand domain EF-hand_7 PF13499.6 ELR11849.1 - 0.0021 18.5 0.0 0.016 15.6 0.0 2.1 2 0 0 2 2 2 1 EF-hand domain pair Histone PF00125.24 ELR11850.1 - 0.067 13.5 0.0 0.43 10.9 0.0 2.1 2 0 0 2 2 2 0 Core histone H2A/H2B/H3/H4 MVL PF12151.8 ELR11851.1 - 0.035 14.0 0.1 0.08 12.8 0.1 1.5 1 0 0 1 1 1 0 Mannan-binding protein Exonuc_VIII PF06630.11 ELR11852.1 - 0.093 12.6 0.0 0.1 12.4 0.0 1.1 1 0 0 1 1 1 0 Enterobacterial exodeoxyribonuclease VIII FixQ PF05545.11 ELR11853.1 - 0.07 13.1 0.4 0.11 12.5 0.4 1.3 1 0 0 1 1 1 0 Cbb3-type cytochrome oxidase component FixQ Mid2 PF04478.12 ELR11853.1 - 0.077 12.8 0.0 0.083 12.7 0.0 1.2 1 0 0 1 1 1 0 Mid2 like cell wall stress sensor OMP_b-brl_2 PF13568.6 ELR11853.1 - 0.093 12.8 0.0 0.1 12.6 0.0 1.1 1 0 0 1 1 1 0 Outer membrane protein beta-barrel domain MAP17 PF15807.5 ELR11853.1 - 0.23 11.7 0.2 0.3 11.3 0.2 1.3 1 0 0 1 1 1 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 Exonuc_VIII PF06630.11 ELR11854.1 - 0.1 12.5 0.0 0.12 12.2 0.0 1.1 1 0 0 1 1 1 0 Enterobacterial exodeoxyribonuclease VIII Bac_rhodopsin PF01036.18 ELR11855.1 - 6.9e-18 65.0 18.0 1.2e-17 64.2 18.0 1.4 1 1 0 1 1 1 1 Bacteriorhodopsin-like protein HisKA PF00512.25 ELR11855.1 - 0.00029 20.8 0.0 0.00062 19.8 0.0 1.5 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain GNAT_acetyltran PF12746.7 ELR11857.1 - 0.026 14.1 0.0 0.028 14.0 0.0 1.1 1 0 0 1 1 1 0 GNAT acetyltransferase CBS PF00571.28 ELR11859.1 - 4e-12 46.4 0.4 1e-07 32.3 0.1 2.4 2 0 0 2 2 2 2 CBS domain Exo70 PF03081.15 ELR11859.1 - 0.056 12.5 0.0 0.07 12.2 0.0 1.2 1 0 0 1 1 1 0 Exo70 exocyst complex subunit CLU PF13236.6 ELR11860.1 - 6.2e-46 157.0 0.0 1.5e-45 155.8 0.0 1.7 1 0 0 1 1 1 1 Clustered mitochondria RCC1 PF00415.18 ELR11860.1 - 1.4e-25 89.6 0.2 3.5e-10 40.4 0.0 6.3 6 0 0 6 6 6 2 Regulator of chromosome condensation (RCC1) repeat SPRY PF00622.28 ELR11860.1 - 2.3e-19 69.6 0.0 4.4e-19 68.7 0.0 1.5 1 0 0 1 1 1 1 SPRY domain RCC1_2 PF13540.6 ELR11860.1 - 3.1e-19 68.3 7.7 2.1e-06 27.4 0.0 6.2 6 0 0 6 6 6 4 Regulator of chromosome condensation (RCC1) repeat eIF3_p135 PF12807.7 ELR11860.1 - 1.4e-10 41.5 0.3 3e-10 40.4 0.3 1.6 1 0 0 1 1 1 1 Translation initiation factor eIF3 subunit 135 TPR_8 PF13181.6 ELR11860.1 - 0.00029 20.8 0.5 1.2 9.5 0.1 2.8 2 0 0 2 2 2 2 Tetratricopeptide repeat SpoIIIAH PF12685.7 ELR11860.1 - 1.2 8.9 7.6 2.7 7.8 7.6 1.6 1 0 0 1 1 1 0 SpoIIIAH-like protein SDA1 PF05285.12 ELR11860.1 - 1.3 8.4 10.4 2.6 7.4 10.4 1.4 1 0 0 1 1 1 0 SDA1 AF-4 PF05110.13 ELR11860.1 - 1.7 6.6 7.6 2.4 6.1 7.6 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein DNA_pol_phi PF04931.13 ELR11860.1 - 2.3 6.2 11.9 4.1 5.4 11.9 1.3 1 0 0 1 1 1 0 DNA polymerase phi Nop14 PF04147.12 ELR11860.1 - 9.3 4.3 11.9 14 3.7 11.9 1.2 1 0 0 1 1 1 0 Nop14-like family RCC1 PF00415.18 ELR11861.1 - 1.2e-27 96.3 11.8 9.4e-07 29.4 0.0 6.1 5 2 0 5 5 5 5 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 ELR11861.1 - 4.3e-20 71.0 3.2 1.2e-05 24.9 0.0 5.2 5 0 0 5 5 5 4 Regulator of chromosome condensation (RCC1) repeat MMR_HSR1 PF01926.23 ELR11862.1 - 2.6e-16 59.7 0.0 4.7e-16 58.9 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 ELR11862.1 - 4.1e-09 36.1 0.0 6.4e-09 35.5 0.0 1.2 1 0 0 1 1 1 1 Ferrous iron transport protein B Dynamin_N PF00350.23 ELR11862.1 - 0.0012 18.9 0.1 0.035 14.2 0.0 2.2 1 1 1 2 2 2 1 Dynamin family RsgA_GTPase PF03193.16 ELR11862.1 - 0.0039 17.1 0.0 0.0081 16.1 0.0 1.5 1 0 0 1 1 1 1 RsgA GTPase ABC_tran PF00005.27 ELR11862.1 - 0.0077 16.8 0.0 0.16 12.4 0.0 2.2 2 0 0 2 2 2 1 ABC transporter AAA_16 PF13191.6 ELR11862.1 - 0.012 16.0 0.1 0.072 13.5 0.0 2.0 2 0 0 2 2 2 0 AAA ATPase domain AAA_18 PF13238.6 ELR11862.1 - 0.036 14.6 0.1 0.14 12.7 0.0 2.0 2 0 0 2 2 2 0 AAA domain AIG1 PF04548.16 ELR11862.1 - 0.065 12.6 0.0 0.11 11.8 0.0 1.4 1 0 0 1 1 1 0 AIG1 family KAP_NTPase PF07693.14 ELR11862.1 - 0.12 11.6 0.1 0.53 9.5 0.0 1.9 2 0 0 2 2 2 0 KAP family P-loop domain Pkinase_Tyr PF07714.17 ELR11863.1 - 1.2e-69 234.5 0.0 4.9e-62 209.6 0.0 2.1 1 1 1 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 ELR11863.1 - 6.5e-36 124.0 0.0 4e-34 118.2 0.0 2.1 1 1 0 1 1 1 1 Protein kinase domain Kdo PF06293.14 ELR11863.1 - 0.00032 20.1 0.0 0.0005 19.5 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 ELR11863.1 - 0.048 12.4 0.0 0.061 12.1 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase APH PF01636.23 ELR11863.1 - 0.11 12.4 0.0 0.17 11.8 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family DUF3584 PF12128.8 ELR11864.1 - 0.78 7.2 12.4 1 6.8 12.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) MMR_HSR1 PF01926.23 ELR11866.1 - 8.5e-19 67.7 0.1 1.5e-15 57.2 0.0 2.6 2 0 0 2 2 2 2 50S ribosome-binding GTPase FeoB_N PF02421.18 ELR11866.1 - 1.3e-11 44.3 0.1 2e-08 33.9 0.0 2.3 2 0 0 2 2 2 2 Ferrous iron transport protein B GTP_EFTU PF00009.27 ELR11866.1 - 1.1e-06 28.3 1.5 0.00017 21.2 0.5 3.3 2 1 1 3 3 3 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 ELR11866.1 - 1.4e-06 28.3 0.7 0.02 14.8 0.1 2.8 1 1 1 2 2 2 2 RsgA GTPase GN3L_Grn1 PF08701.11 ELR11866.1 - 0.00065 19.7 20.7 0.00065 19.7 20.7 3.3 3 0 0 3 3 3 1 GNL3L/Grn1 putative GTPase AAA_16 PF13191.6 ELR11866.1 - 0.02 15.3 0.3 0.21 11.9 0.0 2.7 3 0 0 3 3 3 0 AAA ATPase domain Dynamin_N PF00350.23 ELR11866.1 - 0.088 12.9 0.0 0.088 12.9 0.0 4.2 2 2 1 3 3 3 0 Dynamin family AAA_18 PF13238.6 ELR11866.1 - 0.41 11.2 0.0 0.41 11.2 0.0 2.8 3 0 0 3 3 3 0 AAA domain ABC_tran PF00005.27 ELR11866.1 - 0.51 10.9 0.0 0.51 10.9 0.0 3.3 3 1 0 3 3 3 0 ABC transporter UPF0767 PF15990.5 ELR11866.1 - 3 8.0 0.0 3 8.0 0.0 3.1 3 0 0 3 3 3 0 UPF0767 family zf-C3HC4_3 PF13920.6 ELR11867.1 - 1e-10 41.3 10.8 1e-10 41.3 10.8 2.7 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 ELR11867.1 - 5.1e-07 29.5 12.0 5.1e-07 29.5 12.0 2.6 2 1 0 2 2 2 1 Prokaryotic RING finger family 4 zf-RING_2 PF13639.6 ELR11867.1 - 0.00038 20.7 11.7 0.00038 20.7 11.7 2.7 2 0 0 2 2 2 1 Ring finger domain zf-RING_UBOX PF13445.6 ELR11867.1 - 0.0019 18.2 6.6 0.0019 18.2 6.6 3.4 3 0 0 3 3 3 1 RING-type zinc-finger zf-RING_5 PF14634.6 ELR11867.1 - 0.0033 17.4 10.3 0.0033 17.4 10.3 3.1 2 2 0 2 2 2 1 zinc-RING finger domain zf-C3HC4 PF00097.25 ELR11867.1 - 0.014 15.3 8.2 0.014 15.3 8.2 2.8 2 1 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 ELR11867.1 - 0.032 14.1 11.4 0.032 14.1 11.4 3.1 2 1 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Resolvase PF00239.21 ELR11867.1 - 0.2 11.8 4.3 3.8 7.6 0.9 2.4 2 0 0 2 2 2 0 Resolvase, N terminal domain SlyX PF04102.12 ELR11867.1 - 0.22 12.1 1.4 0.59 10.8 0.7 2.0 2 0 0 2 2 2 0 SlyX FYVE_2 PF02318.16 ELR11867.1 - 7.5 6.8 18.3 2.2 8.5 2.8 2.5 3 0 0 3 3 3 0 FYVE-type zinc finger PLAC8 PF04749.17 ELR11868.1 - 5.4e-14 53.0 15.1 7.4e-14 52.6 15.1 1.3 1 0 0 1 1 1 1 PLAC8 family Methyltransf_16 PF10294.9 ELR11869.1 - 1.5e-27 96.5 0.2 5.8e-27 94.5 0.2 1.9 1 1 0 1 1 1 1 Lysine methyltransferase Methyltransf_23 PF13489.6 ELR11869.1 - 0.00063 19.6 0.0 0.0013 18.6 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 ELR11869.1 - 0.0065 15.9 0.1 0.011 15.1 0.0 1.3 1 1 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.14 ELR11869.1 - 0.03 13.9 0.0 0.044 13.3 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_25 PF13649.6 ELR11869.1 - 0.03 15.0 0.0 0.055 14.2 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_12 PF08242.12 ELR11869.1 - 0.16 12.7 0.0 0.35 11.6 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain DUF2183 PF09949.9 ELR11870.1 - 2.3e-30 104.9 0.0 1.1e-29 102.7 0.0 2.0 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2183) DUF2514 PF10721.9 ELR11870.1 - 0.044 13.8 0.8 0.092 12.8 0.4 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF2514) DUF4209 PF13910.6 ELR11871.1 - 7.9e-17 61.3 0.2 3.1e-15 56.2 0.0 2.5 2 0 0 2 2 2 1 Domain of unknown function (DUF4209) SnoaL_2 PF12680.7 ELR11872.1 - 4.6e-16 59.3 0.1 5.6e-16 59.0 0.1 1.1 1 0 0 1 1 1 1 SnoaL-like domain DUF4440 PF14534.6 ELR11872.1 - 0.00017 21.9 0.1 0.0002 21.7 0.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4440) SnoaL PF07366.12 ELR11872.1 - 0.00019 21.2 0.0 0.00028 20.7 0.0 1.2 1 0 0 1 1 1 1 SnoaL-like polyketide cyclase SnoaL_3 PF13474.6 ELR11872.1 - 0.00072 19.8 0.1 0.00083 19.6 0.1 1.2 1 0 0 1 1 1 1 SnoaL-like domain Caroten_synth PF04240.12 ELR11873.1 - 1.3e-31 110.1 14.4 2.5e-31 109.2 14.3 1.5 1 1 0 1 1 1 1 Carotenoid biosynthesis protein Ion_trans PF00520.31 ELR11874.1 - 1.5e-07 30.9 10.2 2.3e-07 30.3 10.2 1.2 1 0 0 1 1 1 1 Ion transport protein DSPc PF00782.20 ELR11874.1 - 6.3e-07 29.3 0.0 1.5e-06 28.0 0.0 1.5 1 1 0 1 1 1 1 Dual specificity phosphatase, catalytic domain PTEN_C2 PF10409.9 ELR11874.1 - 6.7e-06 25.9 0.0 2e-05 24.4 0.0 1.7 2 0 0 2 2 2 1 C2 domain of PTEN tumour-suppressor protein TMEM132D_C PF15706.5 ELR11874.1 - 0.31 10.9 1.2 1 9.2 1.2 1.8 1 0 0 1 1 1 0 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term TMEM164 PF14808.6 ELR11875.1 - 1.6e-27 96.5 13.5 7.9e-26 90.9 13.5 2.1 1 1 0 1 1 1 1 TMEM164 family Intg_mem_TP0381 PF09529.10 ELR11875.1 - 9.5e-05 22.0 26.4 0.00032 20.3 18.1 2.2 2 0 0 2 2 2 2 Integral membrane protein (intg_mem_TP0381) PMP1_2 PF08114.11 ELR11875.1 - 0.066 13.0 0.0 0.15 11.8 0.0 1.5 1 0 0 1 1 1 0 ATPase proteolipid family DUF3341 PF11821.8 ELR11875.1 - 0.31 10.7 2.8 0.9 9.2 2.8 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3341) Peptidase_S8 PF00082.22 ELR11876.1 - 4.4e-36 124.7 11.1 1.5e-35 122.9 11.1 1.7 1 1 0 1 1 1 1 Subtilase family Inhibitor_I9 PF05922.16 ELR11876.1 - 0.0072 17.0 0.0 0.013 16.1 0.0 1.5 1 0 0 1 1 1 1 Peptidase inhibitor I9 DUF4611 PF15387.6 ELR11877.1 - 0.12 12.6 4.6 0.24 11.6 4.6 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4611) FAM176 PF14851.6 ELR11877.1 - 0.14 11.8 1.4 0.3 10.7 1.4 1.5 1 0 0 1 1 1 0 FAM176 family CDC45 PF02724.14 ELR11877.1 - 0.34 9.1 5.0 0.49 8.6 5.0 1.2 1 0 0 1 1 1 0 CDC45-like protein GCIP PF13324.6 ELR11877.1 - 0.46 10.0 1.7 0.72 9.4 1.7 1.2 1 0 0 1 1 1 0 Grap2 and cyclin-D-interacting DUF4484 PF14831.6 ELR11877.1 - 0.63 10.1 5.7 1.7 8.7 5.6 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4484) DNA_pol_phi PF04931.13 ELR11877.1 - 0.95 7.5 5.7 1.4 6.9 5.7 1.2 1 0 0 1 1 1 0 DNA polymerase phi LCM PF04072.14 ELR11879.1 - 2.2e-16 60.4 0.0 4.1e-16 59.5 0.0 1.4 1 0 0 1 1 1 1 Leucine carboxyl methyltransferase DDRGK PF09756.9 ELR11880.1 - 5.6e-44 150.0 32.0 5.6e-44 150.0 32.0 1.5 2 0 0 2 2 2 1 DDRGK domain DUF2868 PF11067.8 ELR11880.1 - 0.037 13.5 5.7 0.045 13.3 5.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2868) Mcm10 PF09332.11 ELR11880.1 - 0.081 12.3 25.7 0.098 12.1 25.7 1.1 1 0 0 1 1 1 0 Mcm10 replication factor Nop14 PF04147.12 ELR11880.1 - 0.17 10.1 30.4 0.2 9.8 30.4 1.0 1 0 0 1 1 1 0 Nop14-like family Caldesmon PF02029.15 ELR11880.1 - 0.4 9.4 38.5 0.45 9.2 38.5 1.0 1 0 0 1 1 1 0 Caldesmon MMR1 PF08505.10 ELR11880.1 - 1.6 8.9 12.8 2 8.6 12.8 1.2 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein RR_TM4-6 PF06459.12 ELR11880.1 - 7.5 6.3 26.4 10 5.8 26.4 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DAG_kinase_N PF14513.6 ELR11880.1 - 8.3 6.6 13.9 70 3.6 13.9 2.1 1 1 0 1 1 1 0 Diacylglycerol kinase N-terminus 6PF2K PF01591.18 ELR11881.1 - 1.3e-64 217.5 0.6 4.5e-64 215.8 0.6 1.6 1 1 0 1 1 1 1 6-phosphofructo-2-kinase AAA_33 PF13671.6 ELR11881.1 - 4.3e-06 27.0 0.9 4.3e-06 27.0 0.9 2.2 2 1 0 2 2 2 1 AAA domain KTI12 PF08433.10 ELR11881.1 - 5.1e-05 22.9 0.3 0.07 12.6 0.0 2.1 2 0 0 2 2 2 2 Chromatin associated protein KTI12 Zeta_toxin PF06414.12 ELR11881.1 - 0.04 13.2 0.1 0.78 9.0 0.0 2.4 2 1 0 2 2 2 0 Zeta toxin AAA_16 PF13191.6 ELR11881.1 - 0.066 13.6 1.3 0.37 11.2 0.7 2.3 1 1 1 2 2 2 0 AAA ATPase domain G0-G1_switch_2 PF15103.6 ELR11882.1 - 0.00081 19.8 0.3 0.0012 19.2 0.3 1.2 1 0 0 1 1 1 1 G0/G1 switch protein 2 MAP17 PF15807.5 ELR11882.1 - 0.0026 18.0 0.0 0.0031 17.8 0.0 1.1 1 0 0 1 1 1 1 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 Tim54 PF11711.8 ELR11882.1 - 0.0051 15.6 3.1 0.006 15.4 3.1 1.0 1 0 0 1 1 1 1 Inner membrane protein import complex subunit Tim54 DUF4834 PF16118.5 ELR11882.1 - 0.0062 17.5 0.0 0.0088 17.0 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4834) FAM176 PF14851.6 ELR11882.1 - 0.0073 16.0 5.0 0.012 15.3 5.0 1.4 1 1 0 1 1 1 1 FAM176 family Connexin PF00029.19 ELR11882.1 - 0.012 15.4 0.0 0.014 15.2 0.0 1.0 1 0 0 1 1 1 0 Connexin Afi1 PF07792.12 ELR11882.1 - 0.037 14.5 2.0 0.044 14.3 2.0 1.1 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking UPF0767 PF15990.5 ELR11882.1 - 0.043 14.0 0.7 0.066 13.4 0.6 1.4 1 1 0 1 1 1 0 UPF0767 family DUF2561 PF10812.8 ELR11882.1 - 0.048 13.7 0.0 0.055 13.5 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2561) AIF_C PF14721.6 ELR11882.1 - 0.13 12.6 0.1 0.16 12.3 0.1 1.1 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term SHR3_chaperone PF08229.11 ELR11882.1 - 0.2 10.6 0.0 0.2 10.6 0.0 2.1 2 0 0 2 2 2 0 ER membrane protein SH3 Pox_Ag35 PF03286.14 ELR11882.1 - 0.2 11.4 9.2 0.24 11.2 9.2 1.1 1 0 0 1 1 1 0 Pox virus Ag35 surface protein Nucleo_P87 PF07267.11 ELR11882.1 - 0.3 9.9 4.9 0.36 9.6 4.9 1.0 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 RNA_pol_Rpc4 PF05132.14 ELR11882.1 - 0.35 11.3 7.9 0.44 11.0 7.9 1.1 1 0 0 1 1 1 0 RNA polymerase III RPC4 LapA_dom PF06305.11 ELR11882.1 - 0.98 9.3 3.0 2.6 7.9 3.0 1.7 1 1 0 1 1 1 0 Lipopolysaccharide assembly protein A domain PBP_sp32 PF07222.12 ELR11882.1 - 1.4 8.3 6.9 1.7 8.0 6.9 1.1 1 0 0 1 1 1 0 Proacrosin binding protein sp32 TMEM208_SND2 PF05620.11 ELR11882.1 - 1.9 8.3 4.7 0.34 10.7 0.1 1.8 1 1 1 2 2 2 0 SRP-independent targeting protein 2/TMEM208 DUF4632 PF15451.6 ELR11882.1 - 3.3 7.9 9.2 1.4 9.0 6.3 1.9 1 1 2 3 3 3 0 Domain of unknown function (DUF4632) OAD_gamma PF04277.13 ELR11882.1 - 4.1 8.1 8.2 61 4.3 8.2 2.1 1 1 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain PBP1_TM PF14812.6 ELR11882.1 - 5.6 7.4 12.5 9.6 6.7 12.5 1.4 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal RR_TM4-6 PF06459.12 ELR11882.1 - 6 6.6 8.5 7.3 6.3 8.5 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 HATPase_c PF02518.26 ELR11883.1 - 5e-28 97.8 0.0 8.3e-28 97.1 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 ELR11883.1 - 2e-24 85.9 0.0 3.3e-24 85.2 0.0 1.3 1 0 0 1 1 1 1 Response regulator receiver domain HisKA PF00512.25 ELR11883.1 - 3.2e-15 55.9 0.0 1.4e-14 53.9 0.0 2.1 1 1 0 1 1 1 1 His Kinase A (phospho-acceptor) domain PMAIP1 PF15150.6 ELR11883.1 - 0.6 10.0 0.1 0.6 10.0 0.1 2.0 2 0 0 2 2 2 0 Phorbol-12-myristate-13-acetate-induced Pkinase PF00069.25 ELR11884.1 - 2.6e-76 256.5 0.2 4.2e-76 255.8 0.2 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR11884.1 - 1.3e-41 142.6 0.0 2.1e-41 141.9 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase POLO_box PF00659.18 ELR11884.1 - 3e-28 97.8 1.7 6.4e-15 55.1 0.1 3.5 4 0 0 4 4 4 2 POLO box duplicated region Kinase-like PF14531.6 ELR11884.1 - 6.5e-05 22.4 0.1 0.0053 16.1 0.0 2.2 2 0 0 2 2 2 1 Kinase-like RIO1 PF01163.22 ELR11884.1 - 0.0064 16.1 3.3 0.021 14.4 0.0 2.9 2 1 1 3 3 3 1 RIO1 family Kdo PF06293.14 ELR11884.1 - 0.007 15.7 0.2 0.013 14.8 0.2 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RNA_pol_3_Rpc31 PF11705.8 ELR11884.1 - 1.5 9.0 17.8 12 6.1 0.2 2.4 2 0 0 2 2 2 0 DNA-directed RNA polymerase III subunit Rpc31 SH3_2 PF07653.17 ELR11885.1 - 2.8e-28 97.4 0.1 2.6e-10 39.8 0.0 3.4 3 0 0 3 3 3 3 Variant SH3 domain SH3_9 PF14604.6 ELR11885.1 - 2.6e-26 91.2 2.2 2.3e-09 37.0 0.1 3.3 3 0 0 3 3 3 3 Variant SH3 domain SH3_1 PF00018.28 ELR11885.1 - 3.3e-26 90.6 1.6 3.9e-09 36.0 0.0 3.3 3 0 0 3 3 3 3 SH3 domain RhoGAP PF00620.27 ELR11885.1 - 9.1e-26 90.5 0.1 6.9e-12 45.4 0.0 2.4 2 0 0 2 2 2 2 RhoGAP domain DUF4542 PF15075.6 ELR11885.1 - 0.0024 18.2 0.3 18 5.7 0.0 3.4 3 0 0 3 3 3 1 Domain of unknown function (DUF4542) RPEL PF02755.15 ELR11885.1 - 0.042 13.6 0.7 0.084 12.6 0.7 1.5 1 0 0 1 1 1 0 RPEL repeat MLTR_LBD PF17765.1 ELR11885.1 - 0.13 12.4 0.0 0.36 10.9 0.0 1.7 1 1 0 1 1 1 0 MmyB-like transcription regulator ligand binding domain DUF1421 PF07223.11 ELR11885.1 - 0.17 11.7 0.1 18 5.3 0.0 3.1 3 0 0 3 3 3 0 UBA-like domain (DUF1421) tRNA-synt_2b PF00587.25 ELR11886.1 - 1.4e-40 139.2 0.1 4.1e-40 137.6 0.0 1.7 2 0 0 2 2 2 1 tRNA synthetase class II core domain (G, H, P, S and T) Seryl_tRNA_N PF02403.22 ELR11886.1 - 1.5e-25 89.5 8.5 3.5e-25 88.3 8.5 1.6 1 0 0 1 1 1 1 Seryl-tRNA synthetase N-terminal domain SKA2 PF16740.5 ELR11886.1 - 0.022 14.5 2.3 0.065 13.0 0.9 2.1 1 1 1 2 2 2 0 Spindle and kinetochore-associated protein 2 BRE1 PF08647.11 ELR11886.1 - 0.13 12.4 7.7 0.027 14.5 3.9 1.9 2 0 0 2 2 2 0 BRE1 E3 ubiquitin ligase Occludin_ELL PF07303.13 ELR11886.1 - 0.58 10.9 3.2 1.6 9.5 3.2 1.7 1 0 0 1 1 1 0 Occludin homology domain CENP-H PF05837.12 ELR11886.1 - 0.79 10.2 4.9 1.8 9.0 4.9 1.5 1 0 0 1 1 1 0 Centromere protein H (CENP-H) Sybindin PF04099.12 ELR11887.1 - 1.2e-23 83.6 1.8 2.7e-23 82.5 1.8 1.5 1 1 0 1 1 1 1 Sybindin-like family Sedlin_N PF04628.13 ELR11887.1 - 0.002 18.3 0.4 0.0026 17.9 0.4 1.3 1 0 0 1 1 1 1 Sedlin, N-terminal conserved region MORN_2 PF07661.13 ELR11888.1 - 1.7e-20 70.6 18.9 0.0023 18.0 0.2 8.0 8 0 0 8 8 8 7 MORN repeat variant MORN PF02493.20 ELR11888.1 - 0.0098 15.7 26.1 0.19 11.7 0.4 6.2 6 0 0 6 6 6 3 MORN repeat Fanconi_A PF03511.14 ELR11888.1 - 0.071 13.0 0.1 0.14 12.1 0.1 1.4 1 0 0 1 1 1 0 Fanconi anaemia group A protein PAP2_3 PF14378.6 ELR11889.1 - 9.2e-12 45.0 3.5 1e-11 44.9 3.5 1.0 1 0 0 1 1 1 1 PAP2 superfamily PAP2 PF01569.21 ELR11889.1 - 5.1e-08 32.8 1.5 5.9e-08 32.6 1.5 1.2 1 0 0 1 1 1 1 PAP2 superfamily PAP2_C PF14360.6 ELR11889.1 - 0.0011 19.5 0.7 0.0023 18.4 0.7 1.5 1 0 0 1 1 1 1 PAP2 superfamily C-terminal US10 PF17617.2 ELR11889.1 - 0.039 14.0 1.1 9.2 6.3 0.0 2.1 1 1 1 2 2 2 0 Viral unique short region 10 DUF3180 PF11377.8 ELR11892.1 - 0.04 14.0 5.6 0.25 11.5 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3180) Mito_carr PF00153.27 ELR11893.1 - 8.9e-48 160.2 0.4 1.1e-18 66.9 0.0 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 ELR11893.1 - 0.078 12.1 1.1 1.7 7.8 0.0 3.1 4 0 0 4 4 4 0 Gammaproteobacterial serine protease Dam PF05869.11 ELR11896.1 - 0.002 17.7 0.2 0.0038 16.8 0.2 1.4 1 0 0 1 1 1 1 DNA N-6-adenine-methyltransferase (Dam) RVT_1 PF00078.27 ELR11896.1 - 0.0043 16.6 0.0 0.0074 15.8 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Mito_carr PF00153.27 ELR11898.1 - 1.5e-06 28.1 0.2 2.3e-06 27.4 0.2 1.4 1 1 0 1 1 1 1 Mitochondrial carrier protein Homeodomain PF00046.29 ELR11899.1 - 9.2e-14 51.0 0.9 2.1e-13 49.9 0.9 1.6 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 ELR11899.1 - 0.0026 17.6 0.1 0.0026 17.6 0.1 2.4 3 0 0 3 3 3 1 Homeobox KN domain LRR_8 PF13855.6 ELR11900.1 - 1.6e-20 72.6 14.8 5.7e-10 38.8 4.5 3.3 2 1 1 3 3 3 3 Leucine rich repeat LRR_4 PF12799.7 ELR11900.1 - 8.1e-18 64.2 13.3 3e-07 30.6 0.2 3.4 3 0 0 3 3 3 3 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 ELR11900.1 - 1.5e-08 34.4 2.5 0.00014 21.5 0.2 2.3 1 1 1 2 2 2 2 Leucine-rich repeat LRR_1 PF00560.33 ELR11900.1 - 0.011 16.1 21.4 1.4 9.8 0.8 6.2 6 1 0 6 6 6 0 Leucine Rich Repeat Abhydrolase_1 PF00561.20 ELR11901.1 - 1.8e-19 70.4 0.0 1.8e-17 63.8 0.0 2.1 2 0 0 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 ELR11901.1 - 3.1e-16 60.7 3.4 3.4e-16 60.5 2.8 1.4 2 0 0 2 2 2 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 ELR11901.1 - 0.00045 19.6 0.0 0.005 16.1 0.0 2.0 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_4 PF08386.10 ELR11901.1 - 0.0065 16.6 0.0 0.012 15.8 0.0 1.4 1 0 0 1 1 1 1 TAP-like protein DUF1057 PF06342.12 ELR11901.1 - 0.023 13.7 0.0 0.034 13.2 0.0 1.1 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF1057) Zn_dep_PLPC PF00882.18 ELR11901.1 - 0.027 14.5 0.2 0.2 11.6 0.0 2.1 2 0 0 2 2 2 0 Zinc dependent phospholipase C DUF4262 PF14081.6 ELR11901.1 - 0.095 12.9 0.2 0.55 10.5 0.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4262) Put_Phosphatase PF06888.12 ELR11902.1 - 2.6e-57 193.9 0.2 6.1e-57 192.7 0.2 1.5 1 1 0 1 1 1 1 Putative Phosphatase HAD PF12710.7 ELR11902.1 - 1.9e-10 41.4 1.4 2.2e-08 34.7 1.4 2.4 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 ELR11902.1 - 0.06 13.4 0.9 1.8 8.6 0.2 2.6 2 1 0 2 2 2 0 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 ELR11902.1 - 0.11 12.8 0.0 2.1 8.6 0.0 2.4 2 1 0 2 2 2 0 haloacid dehalogenase-like hydrolase N_BRCA1_IG PF16158.5 ELR11904.1 - 2.5e-32 111.6 0.0 5.8e-32 110.5 0.0 1.6 1 0 0 1 1 1 1 Ig-like domain from next to BRCA1 gene PB1 PF00564.24 ELR11904.1 - 1.9e-13 50.2 0.0 3.7e-13 49.2 0.0 1.5 1 0 0 1 1 1 1 PB1 domain ZZ PF00569.17 ELR11904.1 - 0.0024 17.6 7.7 0.0046 16.7 7.7 1.4 1 0 0 1 1 1 1 Zinc finger, ZZ type UBA PF00627.31 ELR11904.1 - 0.043 13.7 0.1 0.091 12.7 0.1 1.6 1 0 0 1 1 1 0 UBA/TS-N domain CUE PF02845.16 ELR11904.1 - 0.064 13.0 0.0 0.13 12.0 0.0 1.6 1 0 0 1 1 1 0 CUE domain DZR PF12773.7 ELR11904.1 - 0.13 12.3 3.8 0.34 11.0 3.8 1.7 1 0 0 1 1 1 0 Double zinc ribbon SDA1 PF05285.12 ELR11904.1 - 4.9 6.5 18.3 6.8 6.0 18.3 1.1 1 0 0 1 1 1 0 SDA1 zf-RanBP PF00641.18 ELR11906.1 - 2.7e-08 33.0 12.9 0.00012 21.3 3.4 2.3 2 0 0 2 2 2 2 Zn-finger in Ran binding protein and others AvrRpt-cleavage PF05627.11 ELR11906.1 - 0.011 15.0 0.4 3.7 7.0 0.0 2.5 2 0 0 2 2 2 0 Cleavage site for pathogenic type III effector avirulence factor Avr COE1_HLH PF16423.5 ELR11906.1 - 0.15 11.7 0.2 26 4.6 0.1 2.5 2 0 0 2 2 2 0 Transcription factor COE1 helix-loop-helix domain DUF326 PF03860.16 ELR11906.1 - 3.3 7.8 13.3 3.6 7.7 2.4 2.5 2 0 0 2 2 2 0 Domain of Unknown Function (DUF326) RANK_CRD_2 PF18278.1 ELR11906.1 - 3.7 7.8 10.6 1.4 9.1 1.1 3.2 3 0 0 3 3 3 0 Receptor activator of the NF-KB cysteine-rich repeat domain 2 DUF5363 PF17320.2 ELR11906.1 - 5.3 7.0 6.9 16 5.4 0.6 2.4 2 0 0 2 2 2 0 Family of unknown function (DUF5363) DUF2804 PF10974.8 ELR11908.1 - 1.1e-56 192.8 0.0 1.2e-30 107.2 0.0 2.0 1 1 1 2 2 2 2 Protein of unknown function (DUF2804) zf-HC5HC2H PF13771.6 ELR11910.1 - 0.029 14.6 2.8 0.06 13.6 2.8 1.5 1 0 0 1 1 1 0 PHD-like zinc-binding domain N6_N4_Mtase PF01555.18 ELR11910.1 - 0.041 13.6 0.0 0.067 12.9 0.0 1.4 1 0 0 1 1 1 0 DNA methylase C1_1 PF00130.22 ELR11910.1 - 0.042 13.7 3.4 0.081 12.8 3.4 1.5 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) DUF2116 PF09889.9 ELR11910.1 - 3.3 7.8 6.2 0.9 9.6 0.3 2.2 1 1 1 2 2 2 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) Mucin PF01456.17 ELR11914.1 - 1.1 9.2 36.1 3.1 7.8 36.1 1.8 1 1 0 1 1 1 0 Mucin-like glycoprotein Macoilin PF09726.9 ELR11914.1 - 2.2 6.7 16.2 2.8 6.4 16.2 1.0 1 0 0 1 1 1 0 Macoilin family Mitofilin PF09731.9 ELR11914.1 - 2.3 7.0 8.7 2.7 6.7 8.7 1.1 1 0 0 1 1 1 0 Mitochondrial inner membrane protein Dicty_REP PF05086.12 ELR11914.1 - 3.5 5.5 18.6 4.3 5.2 18.6 1.0 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein CENP-F_leu_zip PF10473.9 ELR11915.1 - 4.1e-05 23.6 13.9 0.0072 16.4 9.7 2.3 2 0 0 2 2 2 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 ATG16 PF08614.11 ELR11915.1 - 8.5e-05 22.9 0.2 8.5e-05 22.9 0.2 1.9 2 0 0 2 2 2 1 Autophagy protein 16 (ATG16) Atg14 PF10186.9 ELR11915.1 - 0.015 14.4 8.8 0.023 13.8 8.8 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 TMF_DNA_bd PF12329.8 ELR11915.1 - 0.018 15.1 9.9 0.018 15.1 9.9 2.9 3 1 0 3 3 3 0 TATA element modulatory factor 1 DNA binding DUF2031 PF09592.10 ELR11915.1 - 0.05 13.1 6.1 0.075 12.6 6.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2031) CwsA PF10814.8 ELR11915.1 - 0.058 13.6 0.2 0.13 12.4 0.2 1.6 1 1 0 1 1 1 0 Cell wall synthesis protein CwsA Fib_alpha PF08702.10 ELR11915.1 - 0.068 13.4 7.2 0.42 10.8 3.5 2.3 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family FlaC_arch PF05377.11 ELR11915.1 - 0.24 11.8 9.9 3 8.3 1.8 3.0 3 0 0 3 3 3 0 Flagella accessory protein C (FlaC) FlxA PF14282.6 ELR11915.1 - 0.25 11.3 5.6 19 5.3 4.1 2.8 2 1 0 2 2 2 0 FlxA-like protein AAA_13 PF13166.6 ELR11915.1 - 0.3 9.7 10.9 0.33 9.5 6.4 2.0 1 1 1 2 2 2 0 AAA domain KELK PF15796.5 ELR11915.1 - 0.33 11.4 18.6 0.1 13.1 13.5 2.3 2 0 0 2 2 2 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase Wtap PF17098.5 ELR11915.1 - 0.33 10.9 8.6 2.8 7.8 0.3 3.0 1 1 2 3 3 3 0 WTAP/Mum2p family GAS PF13851.6 ELR11915.1 - 0.34 10.2 13.7 0.5 9.7 9.2 2.4 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding Phage_GP20 PF06810.11 ELR11915.1 - 0.36 10.6 8.4 1 9.1 4.0 2.5 2 1 0 2 2 2 0 Phage minor structural protein GP20 Snapin_Pallidin PF14712.6 ELR11915.1 - 0.41 11.1 8.1 0.72 10.3 0.1 3.0 2 1 1 3 3 3 0 Snapin/Pallidin FAM76 PF16046.5 ELR11915.1 - 0.5 9.7 5.8 0.16 11.3 2.9 1.5 2 0 0 2 2 2 0 FAM76 protein FmiP_Thoc5 PF09766.9 ELR11915.1 - 1.5 8.1 10.1 0.44 9.8 6.6 1.6 1 1 0 1 1 1 0 Fms-interacting protein/Thoc5 DUF4407 PF14362.6 ELR11915.1 - 1.6 8.0 6.4 2.5 7.4 6.2 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) BST2 PF16716.5 ELR11915.1 - 1.8 9.2 12.3 0.26 11.9 2.2 3.4 3 1 0 4 4 3 0 Bone marrow stromal antigen 2 DivIC PF04977.15 ELR11915.1 - 2.9 7.7 10.6 4.1 7.2 0.1 3.4 2 1 1 3 3 3 0 Septum formation initiator DUF4140 PF13600.6 ELR11915.1 - 2.9 8.4 11.2 8.8 6.8 2.9 3.4 2 1 2 4 4 4 0 N-terminal domain of unknown function (DUF4140) Pox_A_type_inc PF04508.12 ELR11915.1 - 3.8 7.5 9.9 2.2 8.3 0.1 4.2 4 0 0 4 4 3 0 Viral A-type inclusion protein repeat CorA PF01544.18 ELR11915.1 - 4.5 6.5 7.7 3 7.1 0.4 2.3 2 0 0 2 2 2 0 CorA-like Mg2+ transporter protein HIP1_clath_bdg PF16515.5 ELR11915.1 - 6.5 7.4 13.3 19 5.9 9.5 2.7 2 1 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 EMP24_GP25L PF01105.24 ELR11915.1 - 6.8 6.6 10.4 32 4.4 7.9 2.7 1 1 2 3 3 3 0 emp24/gp25L/p24 family/GOLD Prefoldin_2 PF01920.20 ELR11915.1 - 7 6.7 15.5 9 6.3 5.9 3.0 2 1 1 3 3 3 0 Prefoldin subunit DUF641 PF04859.12 ELR11915.1 - 9.6 6.6 11.4 5.3 7.4 7.4 2.2 2 0 0 2 2 2 0 Plant protein of unknown function (DUF641) Mito_carr PF00153.27 ELR11916.1 - 2.4e-68 226.1 3.3 1e-22 79.8 0.0 3.4 3 1 0 3 3 3 3 Mitochondrial carrier protein COG5 PF10392.9 ELR11918.1 - 2.2e-27 95.8 4.1 3.5e-27 95.2 4.1 1.3 1 0 0 1 1 1 1 Golgi transport complex subunit 5 Vps54_N PF10475.9 ELR11918.1 - 3.6e-08 33.0 2.0 4.3e-08 32.8 2.0 1.1 1 0 0 1 1 1 1 Vacuolar-sorting protein 54, of GARP complex Vps51 PF08700.11 ELR11918.1 - 2.8e-06 27.3 0.2 6.3e-06 26.2 0.2 1.6 1 0 0 1 1 1 1 Vps51/Vps67 COG2 PF06148.11 ELR11918.1 - 0.00042 20.4 0.9 0.0008 19.5 0.9 1.5 1 1 0 1 1 1 1 COG (conserved oligomeric Golgi) complex component, COG2 DUF489 PF04356.12 ELR11918.1 - 0.001 19.1 1.6 0.0029 17.6 0.5 1.9 1 1 1 2 2 2 1 Protein of unknown function (DUF489) Baculo_PEP_C PF04513.12 ELR11918.1 - 0.0017 18.4 1.1 0.0035 17.4 1.1 1.5 1 1 0 1 1 1 1 Baculovirus polyhedron envelope protein, PEP, C terminus Cob_adeno_trans PF01923.18 ELR11918.1 - 0.014 15.5 0.5 0.063 13.4 0.1 2.0 1 1 1 2 2 2 0 Cobalamin adenosyltransferase Sec5 PF15469.6 ELR11918.1 - 0.021 14.6 0.1 0.044 13.6 0.1 1.6 1 1 0 1 1 1 0 Exocyst complex component Sec5 NPV_P10 PF05531.12 ELR11918.1 - 0.024 15.1 1.0 0.11 13.0 0.3 2.2 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein Sec3_C_2 PF15278.6 ELR11918.1 - 0.047 14.0 0.1 0.091 13.1 0.1 1.5 1 0 0 1 1 1 0 Sec3 exocyst complex subunit NLRC4_HD2 PF17776.1 ELR11918.1 - 0.062 13.8 1.3 0.11 13.1 0.5 1.7 2 0 0 2 2 2 0 NLRC4 helical domain HD2 RasGAP_C PF03836.15 ELR11918.1 - 0.076 13.2 1.8 0.49 10.5 0.6 2.1 1 1 1 2 2 2 0 RasGAP C-terminus DUF1664 PF07889.12 ELR11918.1 - 0.084 12.9 0.8 0.21 11.6 0.4 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Nuc_recep-AF1 PF11825.8 ELR11918.1 - 0.11 12.6 0.0 11 6.1 0.1 2.1 1 1 1 2 2 2 0 Nuclear/hormone receptor activator site AF-1 Lebercilin PF15619.6 ELR11918.1 - 0.15 11.7 3.5 0.47 10.1 3.5 1.8 1 1 0 1 1 1 0 Ciliary protein causing Leber congenital amaurosis disease DUF4079 PF13301.6 ELR11919.1 - 0.035 14.2 0.2 0.067 13.4 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4079) DUF2951 PF11166.8 ELR11919.1 - 0.15 12.3 0.7 0.38 11.0 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2951) DUF3040 PF11239.8 ELR11919.1 - 1.2 9.4 3.0 9.6 6.6 0.0 3.2 3 1 1 4 4 4 0 Protein of unknown function (DUF3040) Glyco_hydro_16 PF00722.21 ELR11920.1 - 7.3e-21 74.4 0.0 1e-20 73.9 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 PNP_UDP_1 PF01048.20 ELR11921.1 - 2.2e-12 46.7 0.9 5.6e-11 42.1 1.0 2.6 2 1 0 2 2 2 1 Phosphorylase superfamily zf-RanBP PF00641.18 ELR11921.1 - 8.1e-07 28.2 0.9 1.4e-06 27.4 0.9 1.3 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others F-box-like PF12937.7 ELR11921.1 - 0.0017 18.2 1.5 0.0035 17.2 1.5 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ELR11921.1 - 0.046 13.6 0.9 0.097 12.6 0.9 1.5 1 0 0 1 1 1 0 F-box domain PGA_cap PF09587.10 ELR11922.1 - 0.058 12.8 0.0 0.096 12.1 0.0 1.2 1 0 0 1 1 1 0 Bacterial capsule synthesis protein PGA_cap CDC45 PF02724.14 ELR11922.1 - 1.4 7.1 7.4 1.7 6.8 7.4 1.1 1 0 0 1 1 1 0 CDC45-like protein TRAM_LAG1_CLN8 PF03798.16 ELR11923.1 - 2.7e-29 102.3 18.3 2.7e-29 102.3 18.3 1.3 2 0 0 2 2 2 1 TLC domain DUF4118 PF13493.6 ELR11923.1 - 0.026 14.3 0.9 0.026 14.3 0.9 3.2 4 0 0 4 4 4 0 Domain of unknown function (DUF4118) CPP1-like PF11833.8 ELR11923.1 - 0.27 10.9 1.7 0.77 9.4 0.5 2.1 1 1 1 2 2 2 0 Protein CHAPERONE-LIKE PROTEIN OF POR1-like DUF4083 PF13314.6 ELR11923.1 - 0.3 11.1 0.2 0.3 11.1 0.2 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4083) Ctr PF04145.15 ELR11924.1 - 1.6e-13 51.6 0.0 1.7e-13 51.4 0.0 1.1 1 0 0 1 1 1 1 Ctr copper transporter family DUF4381 PF14316.6 ELR11924.1 - 0.005 17.1 0.0 0.0059 16.9 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4381) DUF4231 PF14015.6 ELR11924.1 - 0.054 14.0 0.1 0.078 13.4 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4231) LapA_dom PF06305.11 ELR11924.1 - 0.11 12.3 0.0 0.22 11.4 0.0 1.6 1 1 0 1 1 1 0 Lipopolysaccharide assembly protein A domain Par3_HAL_N_term PF12053.8 ELR11925.1 - 1e-10 41.7 0.6 5.2e-10 39.4 0.3 2.3 2 0 0 2 2 2 1 N-terminal of Par3 and HAL proteins Ras PF00071.22 ELR11926.1 - 2e-57 193.3 0.0 2.4e-57 193.1 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR11926.1 - 7.2e-20 71.4 0.0 9.9e-20 70.9 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR11926.1 - 6.2e-08 32.3 0.0 7.3e-08 32.1 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 ELR11926.1 - 1.8e-05 24.4 0.1 6.7e-05 22.5 0.1 1.9 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 ELR11926.1 - 0.00013 21.9 0.3 0.46 10.4 0.0 2.3 1 1 0 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 ELR11926.1 - 0.00028 20.9 0.0 0.00045 20.3 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase ATP_bind_1 PF03029.17 ELR11926.1 - 0.00045 20.1 0.4 0.088 12.6 0.0 2.1 1 1 1 2 2 2 2 Conserved hypothetical ATP binding protein Septin PF00735.18 ELR11926.1 - 0.035 13.4 0.0 0.063 12.6 0.0 1.5 1 0 0 1 1 1 0 Septin FeoB_N PF02421.18 ELR11926.1 - 0.056 13.0 0.1 0.35 10.4 0.1 2.1 1 1 0 1 1 1 0 Ferrous iron transport protein B ParA PF10609.9 ELR11926.1 - 0.078 12.4 0.0 0.17 11.3 0.0 1.5 2 0 0 2 2 2 0 NUBPL iron-transfer P-loop NTPase Peptidase_M14 PF00246.24 ELR11927.1 - 2.8e-87 293.2 0.1 3.6e-87 292.8 0.1 1.1 1 0 0 1 1 1 1 Zinc carboxypeptidase PARP PF00644.20 ELR11928.1 - 2.2e-09 37.2 0.0 4.9e-09 36.1 0.0 1.5 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain CUE PF02845.16 ELR11928.1 - 0.0011 18.6 0.8 0.0041 16.8 0.0 2.3 2 0 0 2 2 2 1 CUE domain Cwf_Cwc_15 PF04889.12 ELR11928.1 - 0.0036 17.1 5.8 0.0036 17.1 5.8 2.9 2 1 0 2 2 2 1 Cwf15/Cwc15 cell cycle control protein DUF3446 PF11928.8 ELR11928.1 - 0.37 11.1 11.5 0.3 11.4 8.2 2.1 2 0 0 2 2 2 0 Early growth response N-terminal domain DUF3253 PF11625.8 ELR11928.1 - 1.3 9.3 9.2 3.9 7.8 0.0 3.5 3 0 0 3 3 3 0 Protein of unknown function (DUF3253) Dabb PF07876.12 ELR11929.1 - 6.2e-16 58.8 0.0 8.3e-16 58.4 0.0 1.2 1 0 0 1 1 1 1 Stress responsive A/B Barrel Domain LCAT PF02450.15 ELR11930.1 - 1.7e-57 195.4 0.0 1.7e-48 165.8 0.0 2.6 2 0 0 2 2 2 2 Lecithin:cholesterol acyltransferase C2 PF00168.30 ELR11930.1 - 2.5e-29 101.6 0.2 3.4e-13 49.8 0.0 2.4 2 0 0 2 2 2 2 C2 domain PX PF00787.24 ELR11930.1 - 5.2e-07 29.6 0.4 1.4e-06 28.3 0.4 1.7 1 0 0 1 1 1 1 PX domain DUF676 PF05057.14 ELR11930.1 - 0.0024 17.4 0.0 0.0058 16.2 0.0 1.6 1 0 0 1 1 1 1 Putative serine esterase (DUF676) DUF726 PF05277.12 ELR11930.1 - 0.012 14.5 0.0 0.021 13.8 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF726) PGAP1 PF07819.13 ELR11930.1 - 0.13 11.9 0.0 0.27 10.9 0.0 1.5 1 0 0 1 1 1 0 PGAP1-like protein Usp PF00582.26 ELR11931.1 - 8.8e-06 26.3 0.0 2.8e-05 24.6 0.0 1.7 1 1 0 1 1 1 1 Universal stress protein family NDUF_B7 PF05676.13 ELR11932.1 - 4.6e-05 23.1 2.2 6.2e-05 22.7 2.2 1.2 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) CHCH PF06747.13 ELR11932.1 - 0.0013 18.8 4.2 0.0027 17.8 4.2 1.6 1 0 0 1 1 1 1 CHCH domain V-SNARE_C PF12352.8 ELR11933.1 - 2.3e-14 53.4 4.6 2.3e-14 53.4 4.6 2.1 2 0 0 2 2 2 1 Snare region anchored in the vesicle membrane C-terminus Sec20 PF03908.13 ELR11933.1 - 9.8e-07 28.6 4.8 6e-06 26.1 0.3 3.2 3 1 0 3 3 3 1 Sec20 Peptidase_S49_N PF08496.10 ELR11933.1 - 1.6 8.8 5.6 0.76 9.8 3.0 1.9 1 1 0 2 2 2 0 Peptidase family S49 N-terminal Fibin PF15819.5 ELR11933.1 - 1.8 8.3 8.0 6.9 6.4 2.9 2.2 1 1 1 2 2 2 0 Fin bud initiation factor homologue Mito_carr PF00153.27 ELR11934.1 - 0.0001 22.1 0.1 0.00029 20.7 0.1 1.7 1 0 0 1 1 1 1 Mitochondrial carrier protein META PF03724.16 ELR11935.1 - 0.0012 18.7 0.0 0.0018 18.2 0.0 1.3 1 0 0 1 1 1 1 META domain Ras PF00071.22 ELR11936.1 - 6.6e-61 204.6 2.5 7.6e-61 204.4 2.5 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR11936.1 - 7.4e-38 129.4 0.5 1.2e-37 128.8 0.5 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR11936.1 - 8.9e-14 51.3 0.2 1.2e-13 50.8 0.2 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 ELR11936.1 - 9.4e-08 32.1 0.1 1.6e-07 31.4 0.1 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 ELR11936.1 - 0.00014 21.5 0.6 0.00037 20.1 0.5 1.6 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Septin PF00735.18 ELR11936.1 - 0.00023 20.5 0.5 0.0004 19.7 0.1 1.5 2 0 0 2 2 2 1 Septin Gtr1_RagA PF04670.12 ELR11936.1 - 0.00039 19.8 0.6 0.00074 18.9 0.6 1.4 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 ELR11936.1 - 0.00061 19.7 2.5 0.12 12.2 0.3 2.3 1 1 0 2 2 2 2 RsgA GTPase AAA_24 PF13479.6 ELR11936.1 - 0.0049 16.6 0.6 0.0076 16.0 0.6 1.7 1 1 0 1 1 1 1 AAA domain PRK PF00485.18 ELR11936.1 - 0.013 15.2 1.1 0.039 13.7 0.5 1.9 1 1 1 2 2 2 0 Phosphoribulokinase / Uridine kinase family RNA_helicase PF00910.22 ELR11936.1 - 0.014 15.8 0.1 0.038 14.4 0.1 2.0 1 1 0 1 1 1 0 RNA helicase AAA_7 PF12775.7 ELR11936.1 - 0.014 14.9 0.2 0.024 14.2 0.2 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region TniB PF05621.11 ELR11936.1 - 0.016 14.6 0.0 0.026 14.0 0.0 1.3 1 0 0 1 1 1 0 Bacterial TniB protein AAA_30 PF13604.6 ELR11936.1 - 0.017 14.9 0.1 0.02 14.6 0.1 1.3 1 1 0 1 1 1 0 AAA domain AAA_16 PF13191.6 ELR11936.1 - 0.02 15.3 0.0 0.039 14.4 0.0 1.5 1 1 0 1 1 1 0 AAA ATPase domain AAA_22 PF13401.6 ELR11936.1 - 0.021 15.1 0.0 0.047 14.0 0.0 1.7 1 1 0 1 1 1 0 AAA domain ABC_tran PF00005.27 ELR11936.1 - 0.054 14.0 0.3 0.095 13.2 0.3 1.6 1 1 0 1 1 1 0 ABC transporter MCM PF00493.23 ELR11936.1 - 0.071 12.2 0.1 0.13 11.4 0.1 1.4 1 0 0 1 1 1 0 MCM P-loop domain DUF87 PF01935.17 ELR11936.1 - 0.22 11.6 1.5 1.5 8.8 0.2 2.1 2 1 0 2 2 2 0 Helicase HerA, central domain Filamin PF00630.19 ELR11937.1 - 2.9e-51 172.6 0.0 3.9e-14 53.3 0.0 4.3 4 0 0 4 4 4 4 Filamin/ABP280 repeat Folate_rec PF03024.14 ELR11937.1 - 4.8e-26 91.6 25.6 5.3e-15 55.7 11.8 2.3 2 0 0 2 2 2 2 Folate receptor family Invasin_D3 PF09134.10 ELR11937.1 - 2.5e-12 47.0 0.0 0.0016 18.7 0.0 3.6 3 0 0 3 3 3 3 Invasin, domain 3 NPC1_N PF16414.5 ELR11937.1 - 9e-08 32.0 13.1 0.00021 20.9 4.2 2.2 2 0 0 2 2 2 2 Niemann-Pick C1 N terminus YtkA PF13115.6 ELR11937.1 - 0.0001 22.9 0.4 0.31 11.7 0.0 4.0 4 0 0 4 4 4 1 YtkA-like Neurexophilin PF06312.12 ELR11937.1 - 0.00012 21.6 0.0 2.4 7.6 0.0 3.3 3 0 0 3 3 3 2 Neurexophilin TPT PF03151.16 ELR11938.1 - 2.2e-50 171.7 31.9 2.1e-49 168.5 31.9 1.9 1 1 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 ELR11938.1 - 5.8e-13 49.2 37.3 2.2e-11 44.1 14.8 2.4 2 1 0 2 2 2 2 EamA-like transporter family UAA PF08449.11 ELR11938.1 - 3.9e-11 42.7 28.0 4.9e-11 42.4 28.0 1.1 1 0 0 1 1 1 1 UAA transporter family PUNUT PF16913.5 ELR11938.1 - 0.00048 19.5 4.8 0.00048 19.5 4.8 3.1 2 1 0 3 3 3 1 Purine nucleobase transmembrane transport TLD PF07534.16 ELR11939.1 - 6.8e-27 94.4 0.0 1.1e-26 93.7 0.0 1.3 1 0 0 1 1 1 1 TLD RabGAP-TBC PF00566.18 ELR11939.1 - 7e-16 58.5 0.1 1.2e-14 54.5 0.0 2.6 2 1 0 2 2 2 1 Rab-GTPase-TBC domain CALM_bind PF16025.5 ELR11939.1 - 3 8.4 7.0 7.9 7.0 7.0 1.7 1 0 0 1 1 1 0 Calcium-dependent calmodulin binding Usp PF00582.26 ELR11941.1 - 1.4e-26 93.7 0.2 1.3e-20 74.4 0.0 2.0 1 1 1 2 2 2 2 Universal stress protein family SRP54 PF00448.22 ELR11941.1 - 0.0069 16.0 0.2 0.0083 15.8 0.2 1.1 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain GSDH PF07995.11 ELR11941.1 - 0.062 12.6 0.0 0.069 12.4 0.0 1.1 1 0 0 1 1 1 0 Glucose / Sorbosone dehydrogenase Pkinase PF00069.25 ELR11942.1 - 8.4e-52 176.1 0.0 1.2e-51 175.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR11942.1 - 2.9e-33 115.3 0.0 3.9e-33 114.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 ELR11942.1 - 4.7e-06 25.6 0.0 6.7e-06 25.1 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 ELR11942.1 - 1.6e-05 24.4 0.0 2.9e-05 23.5 0.0 1.4 1 1 0 1 1 1 1 Kinase-like YrbL-PhoP_reg PF10707.9 ELR11942.1 - 0.0053 16.3 0.0 0.0082 15.7 0.0 1.3 1 0 0 1 1 1 1 PhoP regulatory network protein YrbL Haspin_kinase PF12330.8 ELR11942.1 - 0.0055 15.7 0.1 0.043 12.7 0.1 1.9 1 1 0 1 1 1 1 Haspin like kinase domain RIO1 PF01163.22 ELR11942.1 - 0.044 13.4 0.0 0.068 12.8 0.0 1.2 1 0 0 1 1 1 0 RIO1 family Seadorna_VP7 PF07387.11 ELR11942.1 - 0.052 12.6 0.0 0.11 11.6 0.0 1.4 1 0 0 1 1 1 0 Seadornavirus VP7 Ras PF00071.22 ELR11943.1 - 1.8e-43 147.9 0.2 4.2e-40 137.0 0.0 3.4 2 1 0 2 2 2 1 Ras family BTB PF00651.31 ELR11943.1 - 5.2e-25 87.8 0.0 3.8e-10 40.0 0.0 4.7 4 1 0 4 4 4 3 BTB/POZ domain Roc PF08477.13 ELR11943.1 - 1.6e-16 60.6 0.2 1.6e-08 34.8 0.0 3.5 2 1 1 3 3 3 2 Ras of Complex, Roc, domain of DAPkinase U-box PF04564.15 ELR11943.1 - 2.5e-10 40.4 0.0 5.2e-10 39.3 0.0 1.5 1 0 0 1 1 1 1 U-box domain BACK PF07707.15 ELR11943.1 - 0.00045 20.3 0.0 0.0077 16.3 0.0 2.7 3 0 0 3 3 3 1 BTB And C-terminal Kelch SR-25 PF10500.9 ELR11943.1 - 0.005 16.5 26.3 0.005 16.5 26.3 1.9 2 0 0 2 2 2 1 Nuclear RNA-splicing-associated protein Ribosomal_60s PF00428.19 ELR11943.1 - 0.015 15.8 6.1 0.015 15.8 6.1 4.4 2 1 1 3 3 3 0 60s Acidic ribosomal protein Arf PF00025.21 ELR11943.1 - 0.022 14.2 0.0 0.22 11.0 0.0 2.4 2 1 0 2 2 2 0 ADP-ribosylation factor family MTBP_C PF14920.6 ELR11943.1 - 1.3 8.7 19.0 6.2 6.5 12.2 2.2 2 0 0 2 2 2 0 MDM2-binding Zip PF02535.22 ELR11943.1 - 9.5 5.3 16.3 30 3.7 12.1 2.1 2 0 0 2 2 2 0 ZIP Zinc transporter YL1 PF05764.13 ELR11944.1 - 0.00044 20.4 17.7 0.00044 20.4 17.7 2.2 2 0 0 2 2 2 1 YL1 nuclear protein CDC45 PF02724.14 ELR11944.1 - 0.0035 15.7 21.2 0.0062 14.9 21.2 1.3 1 0 0 1 1 1 1 CDC45-like protein NAM-associated PF14303.6 ELR11944.1 - 0.009 16.7 15.0 0.009 16.7 15.0 2.4 2 0 0 2 2 2 1 No apical meristem-associated C-terminal domain SGT1 PF07093.11 ELR11944.1 - 0.024 13.1 5.7 0.038 12.5 5.7 1.2 1 0 0 1 1 1 0 SGT1 protein SR-25 PF10500.9 ELR11944.1 - 0.52 9.9 41.4 0.013 15.1 13.9 2.2 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein Apt1 PF10351.9 ELR11944.1 - 2.5 6.9 18.7 0.46 9.3 11.8 2.1 2 0 0 2 2 2 0 Golgi-body localisation protein domain RP-C_C PF11800.8 ELR11944.1 - 5.6 7.0 6.1 16 5.5 6.1 1.7 1 0 0 1 1 1 0 Replication protein C C-terminal region Ribosomal_L21p PF00829.21 ELR11945.1 - 7.9e-35 119.2 4.1 1.1e-34 118.7 4.1 1.2 1 0 0 1 1 1 1 Ribosomal prokaryotic L21 protein SAM_MT PF04445.13 ELR11945.1 - 0.036 13.5 0.2 0.051 13.0 0.2 1.1 1 0 0 1 1 1 0 Putative SAM-dependent methyltransferase WD40 PF00400.32 ELR11946.1 - 6.8e-15 55.2 9.7 0.00054 20.7 0.0 6.7 6 1 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ELR11946.1 - 4.1e-05 23.8 0.0 2.1 8.7 0.0 3.8 3 2 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ELR11946.1 - 0.00082 18.4 0.1 0.58 9.1 0.0 3.1 1 1 1 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein PQQ_3 PF13570.6 ELR11946.1 - 0.014 15.9 0.1 1.5 9.4 0.1 3.4 4 0 0 4 4 4 0 PQQ-like domain WD40_like PF17005.5 ELR11946.1 - 0.03 13.6 0.1 2.4 7.4 0.1 2.1 1 1 0 1 1 1 0 WD40-like domain YL1 PF05764.13 ELR11946.1 - 0.032 14.3 1.8 0.032 14.3 1.8 1.9 2 0 0 2 2 2 0 YL1 nuclear protein Atg31 PF09795.9 ELR11946.1 - 3.6 7.6 6.9 0.11 12.4 0.7 1.7 2 0 0 2 2 2 0 Autophagy-related protein 31 WD40 PF00400.32 ELR11947.1 - 2.5e-08 34.4 11.1 0.0092 16.8 0.1 6.7 7 0 0 7 7 7 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ELR11947.1 - 0.0033 17.7 0.1 0.33 11.3 0.0 3.6 3 1 0 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain Mpp10 PF04006.12 ELR11947.1 - 0.36 9.2 20.5 0.58 8.5 20.5 1.2 1 0 0 1 1 1 0 Mpp10 protein GREB1 PF15782.5 ELR11947.1 - 4.7 4.2 7.7 7.1 3.6 0.0 2.2 2 0 0 2 2 2 0 Gene regulated by oestrogen in breast cancer Nop14 PF04147.12 ELR11947.1 - 7 4.7 24.7 9.4 4.3 24.7 1.1 1 0 0 1 1 1 0 Nop14-like family Beta-lactamase PF00144.24 ELR11948.1 - 2.5e-45 155.2 3.0 3e-45 154.9 3.0 1.0 1 0 0 1 1 1 1 Beta-lactamase DUF4989 PF16379.5 ELR11948.1 - 0.035 13.4 0.0 0.049 13.0 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4989) Pyridoxal_deC PF00282.19 ELR11949.1 - 3.5e-184 611.8 0.1 1.4e-92 310.3 0.0 2.1 2 0 0 2 2 2 2 Pyridoxal-dependent decarboxylase conserved domain Beta_elim_lyase PF01212.21 ELR11949.1 - 8.5e-16 58.1 0.2 1.2e-06 28.0 0.0 2.2 2 0 0 2 2 2 2 Beta-eliminating lyase Aminotran_5 PF00266.19 ELR11949.1 - 2.4e-09 36.7 0.1 0.0018 17.3 0.0 2.2 2 0 0 2 2 2 2 Aminotransferase class-V Aminotran_1_2 PF00155.21 ELR11949.1 - 1.1e-06 28.1 0.1 0.044 13.0 0.0 2.3 2 0 0 2 2 2 2 Aminotransferase class I and II SepSecS PF05889.13 ELR11949.1 - 9.7e-06 24.5 0.0 0.11 11.2 0.0 2.1 2 0 0 2 2 2 2 O-phosphoseryl-tRNA(Sec) selenium transferase, SepSecS DegT_DnrJ_EryC1 PF01041.17 ELR11949.1 - 6.5e-05 22.4 0.3 0.36 10.1 0.0 2.2 2 0 0 2 2 2 2 DegT/DnrJ/EryC1/StrS aminotransferase family OKR_DC_1 PF01276.20 ELR11949.1 - 0.00023 20.0 0.0 0.56 8.9 0.0 2.1 2 0 0 2 2 2 2 Orn/Lys/Arg decarboxylase, major domain DUF4920 PF16267.5 ELR11949.1 - 0.0027 17.7 3.3 1.7 8.7 0.2 2.6 2 0 0 2 2 2 2 Domain of unknown function (DUF4920) Adhesin_P1_N PF18652.1 ELR11949.1 - 0.009 16.0 0.1 6.6 6.8 0.0 2.4 2 0 0 2 2 2 2 Adhesin P1 N-terminal domain Cys_Met_Meta_PP PF01053.20 ELR11949.1 - 0.022 13.3 0.0 6.3 5.2 0.0 2.8 2 2 0 2 2 2 0 Cys/Met metabolism PLP-dependent enzyme Adap_comp_sub PF00928.21 ELR11949.1 - 0.06 12.7 0.0 5.4 6.3 0.0 2.2 2 0 0 2 2 2 0 Adaptor complexes medium subunit family tify PF06200.14 ELR11949.1 - 0.11 11.9 0.2 21 4.5 0.0 2.7 2 0 0 2 2 2 0 tify domain ubiquitin PF00240.23 ELR11951.1 - 5.6e-20 70.9 0.0 8.4e-20 70.3 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 ELR11951.1 - 2e-09 37.2 0.0 3.1e-09 36.5 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like TBK1_ULD PF18396.1 ELR11951.1 - 1.4e-05 25.0 0.0 2.2e-05 24.3 0.0 1.3 1 0 0 1 1 1 1 TANK binding kinase 1 ubiquitin-like domain Rad60-SLD_2 PF13881.6 ELR11951.1 - 3.5e-05 23.9 0.1 9e-05 22.5 0.1 1.7 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.9 ELR11951.1 - 0.0079 16.7 0.0 0.018 15.6 0.0 1.6 2 0 0 2 2 2 1 DUF2407 ubiquitin-like domain Ubiquitin_4 PF18036.1 ELR11951.1 - 0.01 15.9 0.2 0.025 14.6 0.1 1.7 1 1 1 2 2 2 0 Ubiquitin-like domain Ubiquitin_2 PF14560.6 ELR11951.1 - 0.086 13.3 0.1 0.19 12.2 0.0 1.6 2 0 0 2 2 2 0 Ubiquitin-like domain PsiB PF06290.11 ELR11951.1 - 0.14 11.7 0.1 0.23 10.9 0.1 1.4 1 0 0 1 1 1 0 Plasmid SOS inhibition protein (PsiB) WD40 PF00400.32 ELR11952.1 - 3.9e-45 150.9 19.0 1e-09 38.8 0.6 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ELR11952.1 - 5.1e-06 26.7 2.3 0.35 11.2 0.1 5.0 1 1 4 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Nucleoporin_N PF08801.11 ELR11952.1 - 5.5e-05 22.1 0.0 0.96 8.1 0.0 3.9 2 1 2 4 4 4 2 Nup133 N terminal like Nup160 PF11715.8 ELR11952.1 - 0.003 16.3 4.2 5.1 5.6 1.2 4.1 2 2 1 3 3 3 2 Nucleoporin Nup120/160 PQQ_3 PF13570.6 ELR11952.1 - 0.059 13.9 0.3 1.2 9.7 0.0 3.3 5 0 0 5 5 5 0 PQQ-like domain Hydrolase PF00702.26 ELR11953.1 - 1.5e-07 31.9 0.3 0.0048 17.2 0.0 2.4 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase HAD PF12710.7 ELR11953.1 - 1.3e-06 29.0 0.4 0.037 14.4 0.5 3.3 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 ELR11953.1 - 6.7e-05 22.8 0.2 0.0038 17.0 0.0 2.1 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase S6PP PF05116.13 ELR11953.1 - 0.016 14.8 0.0 0.032 13.7 0.0 1.4 1 0 0 1 1 1 0 Sucrose-6F-phosphate phosphohydrolase HAD_2 PF13419.6 ELR11953.1 - 0.02 15.0 0.1 1.3 9.1 0.0 2.8 2 1 1 3 3 3 0 Haloacid dehalogenase-like hydrolase EF-hand_7 PF13499.6 ELR11954.1 - 2.3e-13 50.4 0.1 1.4e-08 35.1 0.1 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 ELR11954.1 - 1e-12 46.9 0.1 0.022 14.6 0.0 4.2 3 1 1 4 4 4 3 EF-hand domain EF-hand_1 PF00036.32 ELR11954.1 - 2e-11 42.6 0.1 0.002 17.6 0.0 3.6 3 0 0 3 3 3 3 EF hand EF-hand_8 PF13833.6 ELR11954.1 - 2.1e-06 27.5 0.5 0.00092 19.0 0.2 3.1 3 1 0 3 3 3 1 EF-hand domain pair EF-hand_5 PF13202.6 ELR11954.1 - 1.3e-05 24.5 0.9 0.028 13.9 0.0 3.5 3 0 0 3 3 3 1 EF hand EF-hand_9 PF14658.6 ELR11954.1 - 0.00066 20.0 0.2 1.1 9.6 0.1 2.6 2 1 1 3 3 3 2 EF-hand domain Dockerin_1 PF00404.18 ELR11954.1 - 0.0053 16.9 0.2 0.0089 16.2 0.2 1.4 1 0 0 1 1 1 1 Dockerin type I domain ATC_hydrolase PF14196.6 ELR11954.1 - 0.027 15.3 0.1 3.8 8.3 0.0 2.1 2 0 0 2 2 2 0 L-2-amino-thiazoline-4-carboxylic acid hydrolase UAE_UbL PF14732.6 ELR11954.1 - 0.069 13.7 0.2 0.11 13.1 0.2 1.4 1 0 0 1 1 1 0 Ubiquitin/SUMO-activating enzyme ubiquitin-like domain PAD_porph PF04371.15 ELR11955.1 - 1.4e-81 274.3 0.0 1.6e-81 274.1 0.0 1.0 1 0 0 1 1 1 1 Porphyromonas-type peptidyl-arginine deiminase Amidinotransf PF02274.17 ELR11955.1 - 0.098 11.7 0.0 0.16 11.1 0.0 1.3 1 0 0 1 1 1 0 Amidinotransferase Pkinase PF00069.25 ELR11956.1 - 8.1e-71 238.5 0.0 1.1e-70 238.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR11956.1 - 1.9e-35 122.4 0.0 2.5e-35 122.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase PH PF00169.29 ELR11956.1 - 5.9e-09 36.4 0.0 1.5e-08 35.1 0.0 1.6 1 0 0 1 1 1 1 PH domain Pkinase_C PF00433.24 ELR11956.1 - 3.5e-06 27.6 0.1 7e-06 26.7 0.1 1.5 1 0 0 1 1 1 1 Protein kinase C terminal domain PH_9 PF15410.6 ELR11956.1 - 4.1e-06 27.1 0.1 2e-05 24.9 0.0 1.9 2 0 0 2 2 2 1 Pleckstrin homology domain Kinase-like PF14531.6 ELR11956.1 - 0.00049 19.5 0.0 0.061 12.6 0.0 2.4 2 1 0 2 2 2 2 Kinase-like PH_13 PF16652.5 ELR11956.1 - 0.0096 15.7 0.1 0.018 14.8 0.1 1.4 1 0 0 1 1 1 1 Pleckstrin homology domain Abhydrolase_2 PF02230.16 ELR11957.1 - 9.4e-51 172.7 0.0 1e-50 172.5 0.0 1.0 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase Peptidase_S9 PF00326.21 ELR11957.1 - 1.9e-08 34.0 0.2 1e-07 31.7 0.0 1.8 1 1 1 2 2 2 1 Prolyl oligopeptidase family Hydrolase_4 PF12146.8 ELR11957.1 - 9.6e-07 28.3 0.0 0.00011 21.6 0.0 2.1 1 1 1 2 2 2 2 Serine aminopeptidase, S33 FSH1 PF03959.13 ELR11957.1 - 1.1e-06 28.5 0.0 1.6e-06 27.9 0.0 1.3 1 0 0 1 1 1 1 Serine hydrolase (FSH1) Abhydrolase_3 PF07859.13 ELR11957.1 - 0.0013 18.6 0.0 0.17 11.7 0.0 2.0 1 1 1 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_4 PF08386.10 ELR11957.1 - 0.0077 16.3 0.0 0.012 15.7 0.0 1.2 1 0 0 1 1 1 1 TAP-like protein Cutinase PF01083.22 ELR11957.1 - 0.016 15.2 0.0 0.031 14.2 0.0 1.4 1 0 0 1 1 1 0 Cutinase Abhydrolase_1 PF00561.20 ELR11957.1 - 0.055 13.1 0.1 0.83 9.2 0.0 2.0 1 1 1 2 2 2 0 alpha/beta hydrolase fold Esterase PF00756.20 ELR11957.1 - 0.096 12.3 0.0 0.11 12.2 0.0 1.2 1 0 0 1 1 1 0 Putative esterase SH2 PF00017.24 ELR11958.1 - 8.3e-25 86.7 0.0 8.7e-15 54.6 0.0 3.6 2 1 0 2 2 2 2 SH2 domain Cbl_N2 PF02761.14 ELR11958.1 - 3.1e-11 43.8 0.1 1.1e-10 42.0 0.0 2.0 2 0 0 2 2 2 1 CBL proto-oncogene N-terminus, EF hand-like domain IBP39 PF11422.8 ELR11958.1 - 0.0016 18.3 0.0 0.003 17.3 0.0 1.4 1 0 0 1 1 1 1 Initiator binding protein 39 kDa Cbl_N3 PF02762.14 ELR11958.1 - 0.012 15.5 0.0 0.044 13.6 0.0 2.0 2 0 0 2 2 2 0 CBL proto-oncogene N-terminus, SH2-like domain DUF727 PF05303.12 ELR11958.1 - 0.048 13.7 0.1 0.27 11.3 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF727) CH PF00307.31 ELR11959.1 - 1.3e-20 73.6 0.0 2.5e-20 72.7 0.0 1.5 1 0 0 1 1 1 1 Calponin homology (CH) domain CAMSAP_CH PF11971.8 ELR11959.1 - 0.0021 17.9 0.0 0.0033 17.2 0.0 1.3 1 0 0 1 1 1 1 CAMSAP CH domain Ras PF00071.22 ELR11961.1 - 4.5e-18 65.4 0.0 7.7e-18 64.6 0.0 1.4 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR11961.1 - 1.2e-10 41.6 0.0 2e-10 40.9 0.0 1.3 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 ELR11961.1 - 0.00096 19.2 0.0 0.0014 18.7 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase Arf PF00025.21 ELR11961.1 - 0.0012 18.3 0.0 0.0018 17.8 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Pkinase PF00069.25 ELR11962.1 - 2e-72 243.8 0.0 2e-72 243.8 0.0 1.7 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR11962.1 - 4.8e-36 124.4 0.2 9.3e-36 123.4 0.2 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 ELR11962.1 - 2.2e-06 27.2 1.3 4.1e-06 26.3 1.3 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 ELR11962.1 - 0.00016 20.7 2.4 0.00016 20.7 2.4 2.4 2 1 0 2 2 2 1 Haspin like kinase domain Kinase-like PF14531.6 ELR11962.1 - 0.00037 19.9 0.3 0.00037 19.9 0.3 2.9 3 1 1 4 4 4 1 Kinase-like APH PF01636.23 ELR11962.1 - 0.044 13.7 0.0 0.26 11.2 0.0 2.1 2 1 1 3 3 3 0 Phosphotransferase enzyme family Glyco_hydro_18 PF00704.28 ELR11963.1 - 3.3e-11 43.5 0.0 7.2e-11 42.4 0.0 1.6 1 1 0 1 1 1 1 Glycosyl hydrolases family 18 UQ_con PF00179.26 ELR11964.1 - 4.9e-18 65.1 0.0 7.8e-18 64.5 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 ELR11964.1 - 0.041 13.6 0.0 0.09 12.5 0.0 1.5 1 0 0 1 1 1 0 Prokaryotic E2 family B PDCD7 PF16021.5 ELR11965.1 - 1.4e-08 34.3 36.6 8.9e-06 25.0 36.6 2.7 1 1 0 1 1 1 1 Programmed cell death protein 7 Myotub-related PF06602.14 ELR11966.1 - 3.9e-65 220.1 0.0 7.8e-65 219.1 0.0 1.5 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain Pkinase_Tyr PF07714.17 ELR11966.1 - 1e-51 175.7 0.0 1.7e-51 175.0 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ELR11966.1 - 1.1e-41 143.0 0.0 1.8e-41 142.2 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain COR PF16095.5 ELR11966.1 - 7.3e-32 110.7 0.0 1.2e-26 93.8 0.0 2.4 2 0 0 2 2 2 2 C-terminal of Roc, COR, domain LRR_8 PF13855.6 ELR11966.1 - 8.5e-26 89.5 35.2 1.2e-05 25.0 0.3 6.4 4 2 0 6 6 6 5 Leucine rich repeat Roc PF08477.13 ELR11966.1 - 1.7e-25 89.5 0.0 3.6e-25 88.5 0.0 1.6 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase LRR_4 PF12799.7 ELR11966.1 - 7.4e-21 73.9 38.9 0.0034 17.7 5.0 8.0 7 1 2 9 9 9 7 Leucine Rich repeats (2 copies) Ras PF00071.22 ELR11966.1 - 3.8e-14 52.6 0.0 6.5e-14 51.8 0.0 1.3 1 0 0 1 1 1 1 Ras family Arf PF00025.21 ELR11966.1 - 3.7e-05 23.2 0.0 8.1e-05 22.1 0.0 1.5 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 ELR11966.1 - 5.4e-05 23.2 0.0 0.00012 22.1 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase LRR_9 PF14580.6 ELR11966.1 - 0.00022 20.8 11.2 0.37 10.3 0.2 4.3 2 1 1 4 4 4 2 Leucine-rich repeat BBL5 PF07289.11 ELR11966.1 - 0.021 13.9 0.0 0.021 13.9 0.0 1.7 2 0 0 2 2 1 0 Bardet-Biedl syndrome 5 protein Septin PF00735.18 ELR11966.1 - 0.09 12.0 0.0 0.18 11.0 0.0 1.5 1 0 0 1 1 1 0 Septin GRAM PF02893.20 ELR11966.1 - 0.11 12.4 0.0 0.29 11.0 0.0 1.6 1 0 0 1 1 1 0 GRAM domain Voldacs PF03517.13 ELR11966.1 - 1.1 9.4 0.0 1.1 9.4 0.0 3.6 5 0 0 5 5 3 0 Regulator of volume decrease after cellular swelling SET PF00856.28 ELR11966.1 - 2 8.8 7.3 2.1 8.7 0.3 3.0 2 1 0 2 2 2 0 SET domain HEAT PF02985.22 ELR11967.1 - 4.4e-08 32.7 1.7 0.52 10.7 0.0 6.4 7 0 0 7 7 7 2 HEAT repeat HEAT_2 PF13646.6 ELR11967.1 - 2.5e-05 24.6 1.5 2.5e-05 24.6 1.5 5.9 6 2 0 6 6 6 1 HEAT repeats Cnd1 PF12717.7 ELR11967.1 - 0.00015 21.9 0.0 0.18 11.9 0.0 2.8 2 1 0 2 2 2 2 non-SMC mitotic condensation complex subunit 1 RTP1_C1 PF10363.9 ELR11967.1 - 0.00046 20.3 0.1 0.014 15.6 0.0 2.8 2 0 0 2 2 2 1 Required for nuclear transport of RNA pol II C-terminus 1 Cohesin_HEAT PF12765.7 ELR11967.1 - 0.00074 19.8 1.3 0.22 11.9 0.2 3.9 4 0 0 4 4 4 1 HEAT repeat associated with sister chromatid cohesion Adaptin_N PF01602.20 ELR11967.1 - 0.00096 17.8 0.6 1.3 7.5 0.0 3.0 3 0 0 3 3 3 2 Adaptin N terminal region RasGEF_N_2 PF14663.6 ELR11967.1 - 0.029 14.8 1.5 88 3.6 0.0 5.0 3 2 2 5 5 5 0 Rapamycin-insensitive companion of mTOR RasGEF_N domain HEAT_EZ PF13513.6 ELR11967.1 - 0.04 14.4 2.4 5.5 7.6 0.0 4.4 3 0 0 3 3 3 0 HEAT-like repeat BNIP2 PF12496.8 ELR11967.1 - 0.058 13.8 1.6 2.3 8.7 1.6 2.4 1 1 0 1 1 1 0 Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2 Proteasom_PSMB PF10508.9 ELR11967.1 - 0.1 11.1 1.0 2.3 6.6 0.0 2.9 3 1 0 3 3 3 0 Proteasome non-ATPase 26S subunit RhoGAP PF00620.27 ELR11968.1 - 7.3e-15 55.1 0.0 1.5e-14 54.1 0.0 1.5 1 0 0 1 1 1 1 RhoGAP domain PH PF00169.29 ELR11968.1 - 2.7e-06 27.8 0.0 5.7e-06 26.8 0.0 1.5 1 0 0 1 1 1 1 PH domain PH_11 PF15413.6 ELR11968.1 - 0.091 13.2 0.0 0.21 12.0 0.0 1.6 1 0 0 1 1 1 0 Pleckstrin homology domain PH_9 PF15410.6 ELR11968.1 - 0.12 12.8 0.0 0.66 10.4 0.0 2.3 3 0 0 3 3 3 0 Pleckstrin homology domain AAA_18 PF13238.6 ELR11969.1 - 0.00032 21.3 0.0 0.0028 18.2 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_5 PF07728.14 ELR11969.1 - 0.006 16.6 0.0 0.014 15.3 0.0 1.7 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) Zeta_toxin PF06414.12 ELR11969.1 - 0.025 13.8 0.0 0.1 11.9 0.0 2.0 1 1 0 1 1 1 0 Zeta toxin TetR_N PF00440.23 ELR11969.1 - 0.035 13.9 0.0 0.073 12.9 0.0 1.5 1 0 0 1 1 1 0 Bacterial regulatory proteins, tetR family AAA_28 PF13521.6 ELR11969.1 - 0.096 12.9 0.0 0.16 12.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain Glyoxalase_4 PF13669.6 ELR11970.1 - 8e-11 42.2 0.0 1.4e-07 31.7 0.0 2.4 2 0 0 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_3 PF13468.6 ELR11970.1 - 7e-07 29.5 0.0 1e-06 29.0 0.0 1.3 1 0 0 1 1 1 1 Glyoxalase-like domain Glyoxalase PF00903.25 ELR11970.1 - 0.024 14.8 0.0 0.056 13.6 0.0 1.7 1 0 0 1 1 1 0 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily DAHP_synth_1 PF00793.20 ELR11971.1 - 5.4e-103 343.6 0.0 6.7e-103 343.3 0.0 1.0 1 0 0 1 1 1 1 DAHP synthetase I family Alpha-amylase PF00128.24 ELR11972.1 - 2.6e-52 178.4 0.0 4.4e-52 177.7 0.0 1.3 1 0 0 1 1 1 1 Alpha amylase, catalytic domain hDGE_amylase PF14701.6 ELR11972.1 - 0.0017 17.5 1.8 0.0038 16.4 0.0 2.3 3 0 0 3 3 3 1 Glycogen debranching enzyme, glucanotransferase domain FA_hydroxylase PF04116.13 ELR11975.1 - 1.1e-26 93.7 14.3 1.1e-26 93.7 14.3 1.4 2 0 0 2 2 2 1 Fatty acid hydroxylase superfamily Swi3 PF07962.12 ELR11975.1 - 0.41 10.7 1.6 1 9.4 1.6 1.6 1 0 0 1 1 1 0 Replication Fork Protection Component Swi3 DUF5313 PF17240.2 ELR11975.1 - 1.1 9.7 5.0 1.4 9.4 1.5 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF5313) tRNA_m1G_MT PF01746.21 ELR11976.1 - 8.4e-22 77.8 0.0 1.2e-21 77.3 0.0 1.3 1 0 0 1 1 1 1 tRNA (Guanine-1)-methyltransferase UPF0113_N PF17833.1 ELR11976.1 - 0.059 13.9 0.0 0.14 12.7 0.0 1.7 1 1 0 1 1 1 0 UPF0113 Pre-PUA domain CDC45 PF02724.14 ELR11976.1 - 2.9 6.1 7.8 3.5 5.8 7.8 1.1 1 0 0 1 1 1 0 CDC45-like protein Spt20 PF12090.8 ELR11977.1 - 1.3e-23 83.8 0.0 3.4e-14 53.0 0.0 5.1 4 2 1 5 5 5 2 Spt20 family TFIIA PF03153.13 ELR11977.1 - 0.0032 17.5 19.8 0.0032 17.5 19.8 2.9 3 0 0 3 3 3 2 Transcription factor IIA, alpha/beta subunit ubiquitin PF00240.23 ELR11978.1 - 2.1e-21 75.5 0.1 4.9e-21 74.3 0.1 1.6 2 0 0 2 2 2 1 Ubiquitin family Rad60-SLD PF11976.8 ELR11978.1 - 6e-12 45.2 0.0 1.1e-11 44.3 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like STI1 PF17830.1 ELR11978.1 - 3.6e-08 33.2 78.9 0.0002 21.2 1.0 7.0 3 2 3 6 6 6 5 STI1 domain UBA PF00627.31 ELR11978.1 - 5.5e-07 29.4 0.9 5.5e-07 29.4 0.9 3.7 3 0 0 3 3 3 1 UBA/TS-N domain TBK1_ULD PF18396.1 ELR11978.1 - 0.00029 20.7 0.0 0.00082 19.3 0.0 1.7 1 0 0 1 1 1 1 TANK binding kinase 1 ubiquitin-like domain Ubiquitin_2 PF14560.6 ELR11978.1 - 0.0016 18.8 0.0 0.0053 17.2 0.0 1.9 1 1 0 1 1 1 1 Ubiquitin-like domain Keratin_2_head PF16208.5 ELR11978.1 - 0.0066 16.6 43.6 0.66 10.1 2.1 3.8 4 0 0 4 4 4 3 Keratin type II head partial_CstF PF15861.5 ELR11978.1 - 0.0071 16.1 5.7 0.31 10.9 0.6 3.6 2 1 1 3 3 3 1 Partial cleavage stimulation factor domain Dynactin_p22 PF07426.11 ELR11978.1 - 0.023 14.5 5.3 0.42 10.4 0.3 2.6 2 1 0 2 2 2 0 Dynactin subunit p22 Ubiquitin_4 PF18036.1 ELR11978.1 - 0.042 13.9 0.0 0.45 10.6 0.0 2.3 1 1 0 1 1 1 0 Ubiquitin-like domain HOIP-UBA PF16678.5 ELR11978.1 - 0.045 13.8 0.0 0.12 12.4 0.0 1.7 1 0 0 1 1 1 0 HOIP UBA domain pair CUE PF02845.16 ELR11978.1 - 0.083 12.6 0.1 0.083 12.6 0.1 4.4 5 0 0 5 5 4 0 CUE domain E3_UbLigase_EDD PF11547.8 ELR11978.1 - 0.16 11.7 6.0 1.6 8.5 0.1 3.0 3 0 0 3 3 3 0 E3 ubiquitin ligase EDD PUMA PF15826.5 ELR11978.1 - 0.51 10.5 10.7 0.079 13.1 6.1 2.0 2 0 0 2 2 2 0 Bcl-2-binding component 3, p53 upregulated modulator of apoptosis DpnI_C PF17726.1 ELR11978.1 - 0.72 10.0 2.7 1.1 9.4 0.0 2.5 3 0 0 3 3 3 0 Dam-replacing HTH domain GlnE PF03710.15 ELR11978.1 - 0.95 8.8 5.3 2.3 7.6 0.4 2.8 2 1 1 3 3 3 0 Glutamate-ammonia ligase adenylyltransferase DUF535 PF04393.13 ELR11978.1 - 9.9 5.3 8.1 3.4 6.8 2.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF535) Ribo_biogen_C PF04034.13 ELR11979.1 - 3.2e-53 178.8 0.0 4.2e-53 178.4 0.0 1.1 1 0 0 1 1 1 1 Ribosome biogenesis protein, C-terminal RLI PF04068.15 ELR11979.1 - 3.9e-08 33.0 1.1 6.6e-08 32.2 1.1 1.4 1 0 0 1 1 1 1 Possible Fer4-like domain in RNase L inhibitor, RLI BUD22 PF09073.10 ELR11979.1 - 0.017 14.5 31.9 0.021 14.2 31.9 1.1 1 0 0 1 1 1 0 BUD22 Drc1-Sld2 PF11719.8 ELR11979.1 - 0.17 11.4 15.6 0.22 11.0 15.6 1.3 1 0 0 1 1 1 0 DNA replication and checkpoint protein Mpp10 PF04006.12 ELR11979.1 - 0.29 9.5 34.3 0.39 9.1 34.3 1.1 1 0 0 1 1 1 0 Mpp10 protein Nop14 PF04147.12 ELR11979.1 - 0.31 9.2 44.4 0.4 8.8 44.4 1.0 1 0 0 1 1 1 0 Nop14-like family SDA1 PF05285.12 ELR11979.1 - 0.38 10.1 42.0 0.5 9.8 42.0 1.1 1 0 0 1 1 1 0 SDA1 CDC45 PF02724.14 ELR11979.1 - 1.8 6.7 32.8 2.9 6.1 31.0 1.9 2 0 0 2 2 2 0 CDC45-like protein SAPS PF04499.15 ELR11979.1 - 9.6 4.9 17.8 12 4.5 17.8 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Macoilin PF09726.9 ELR11979.1 - 9.7 4.6 7.5 13 4.2 7.5 1.0 1 0 0 1 1 1 0 Macoilin family DUF1981 PF09324.10 ELR11981.1 - 2.5e-34 117.0 1.9 2.5e-34 117.0 1.9 2.2 2 1 1 3 3 3 1 Domain of unknown function (DUF1981) DUF1539 PF07560.11 ELR11981.1 - 0.0041 17.2 0.1 0.0068 16.5 0.1 1.3 1 0 0 1 1 1 1 Domain of Unknown Function (DUF1539) MMS19_N PF14500.6 ELR11981.1 - 0.012 15.2 1.1 0.014 15.0 1.1 1.1 1 0 0 1 1 1 0 Dos2-interacting transcription regulator of RNA-Pol-II HEAT PF02985.22 ELR11981.1 - 0.065 13.5 1.0 3.6 8.1 0.0 3.5 4 0 0 4 4 4 0 HEAT repeat UME PF08064.13 ELR11981.1 - 0.075 12.9 2.0 0.071 13.0 0.7 1.6 2 0 0 2 2 2 0 UME (NUC010) domain Sec7 PF01369.20 ELR11982.1 - 6.1e-45 153.1 0.0 1e-44 152.4 0.0 1.3 1 0 0 1 1 1 1 Sec7 domain Sec7_N PF12783.7 ELR11982.1 - 1.1e-37 129.3 4.7 1.1e-37 129.3 3.0 1.8 2 0 0 2 2 2 1 Guanine nucleotide exchange factor in Golgi transport N-terminal B56 PF01603.20 ELR11982.1 - 0.18 10.7 1.3 0.35 9.8 1.3 1.4 1 0 0 1 1 1 0 Protein phosphatase 2A regulatory B subunit (B56 family) Takusan PF04822.13 ELR11983.1 - 0.078 12.9 1.3 2.8 7.9 0.2 2.8 2 0 0 2 2 2 0 Takusan EGF PF00008.27 ELR11985.1 - 0.25 11.7 2.4 0.77 10.1 2.4 1.8 1 0 0 1 1 1 0 EGF-like domain RCC1_2 PF13540.6 ELR11986.1 - 4.3e-11 42.3 31.3 0.00036 20.2 1.0 7.3 7 0 0 7 7 7 5 Regulator of chromosome condensation (RCC1) repeat Gal_Lectin PF02140.18 ELR11987.1 - 2.8e-08 34.1 0.9 7.9e-08 32.6 0.2 2.2 2 0 0 2 2 2 1 Galactose binding lectin domain EGF PF00008.27 ELR11987.1 - 0.00052 20.3 6.5 0.0016 18.7 6.5 1.9 1 0 0 1 1 1 1 EGF-like domain EGF_2 PF07974.13 ELR11987.1 - 0.0093 16.3 10.0 0.025 14.9 10.0 1.8 1 0 0 1 1 1 1 EGF-like domain P_proprotein PF01483.20 ELR11987.1 - 0.014 15.4 0.1 0.041 13.9 0.1 1.9 1 0 0 1 1 1 0 Proprotein convertase P-domain Ras PF00071.22 ELR11988.1 - 1.7e-46 157.8 0.0 2.3e-46 157.4 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR11988.1 - 6e-30 103.9 0.0 8.3e-30 103.5 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR11988.1 - 6.3e-18 64.8 0.0 8.3e-18 64.4 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 ELR11988.1 - 7.9e-06 25.9 0.0 0.016 15.1 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase Gtr1_RagA PF04670.12 ELR11988.1 - 0.00028 20.3 0.0 0.00036 20.0 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 ELR11988.1 - 0.0019 18.3 0.0 0.0027 17.8 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 ELR11988.1 - 0.0036 16.9 0.0 0.0078 15.8 0.0 1.4 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain AAA_16 PF13191.6 ELR11988.1 - 0.026 14.9 0.0 0.036 14.5 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain TsaE PF02367.17 ELR11988.1 - 0.052 13.5 0.0 0.093 12.7 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE DNA_ligase_A_M PF01068.21 ELR11988.1 - 0.22 11.1 0.0 0.36 10.4 0.0 1.2 1 0 0 1 1 1 0 ATP dependent DNA ligase domain DUF3742 PF12553.8 ELR11990.1 - 0.097 12.8 0.1 0.12 12.5 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3742) Ras PF00071.22 ELR11991.1 - 2.7e-42 144.1 0.0 4.8e-42 143.3 0.0 1.4 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR11991.1 - 9e-27 93.7 0.0 1.6e-26 92.9 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR11991.1 - 6.5e-15 55.0 0.0 8.9e-15 54.6 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 ELR11991.1 - 3e-05 24.0 0.0 0.088 12.7 0.0 2.3 2 0 0 2 2 2 2 RsgA GTPase AAA_16 PF13191.6 ELR11991.1 - 0.00043 20.7 0.0 0.0007 20.0 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain GTP_EFTU PF00009.27 ELR11991.1 - 0.00062 19.4 0.0 0.0015 18.1 0.0 1.6 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain F-box-like PF12937.7 ELR11991.1 - 0.001 18.9 0.1 0.0021 17.9 0.1 1.5 1 0 0 1 1 1 1 F-box-like AAA_33 PF13671.6 ELR11991.1 - 0.012 15.7 0.1 0.035 14.3 0.0 1.7 2 1 0 2 2 2 0 AAA domain AAA_22 PF13401.6 ELR11991.1 - 0.024 14.9 0.0 0.074 13.3 0.0 1.8 1 1 0 1 1 1 0 AAA domain MMR_HSR1 PF01926.23 ELR11991.1 - 0.058 13.5 0.0 0.11 12.6 0.0 1.5 1 0 0 1 1 1 0 50S ribosome-binding GTPase Zeta_toxin PF06414.12 ELR11991.1 - 0.068 12.4 0.0 0.33 10.2 0.0 2.0 3 0 0 3 3 3 0 Zeta toxin HTH_28 PF13518.6 ELR11991.1 - 0.49 10.6 0.1 0.49 10.6 0.1 2.0 2 0 0 2 2 1 0 Helix-turn-helix domain F-box PF00646.33 ELR11991.1 - 0.5 10.3 2.6 0.58 10.1 0.2 2.2 2 0 0 2 2 2 0 F-box domain HC2 PF07382.11 ELR11992.1 - 0.0014 18.8 28.4 0.0024 18.0 18.9 1.8 1 1 0 1 1 1 1 Histone H1-like nucleoprotein HC2 BRCA2 PF00634.18 ELR11992.1 - 0.026 14.2 2.2 39 4.0 0.0 4.6 3 1 1 5 5 5 0 BRCA2 repeat Pentapeptide_4 PF13599.6 ELR11992.1 - 0.069 13.3 0.0 0.33 11.1 0.0 1.8 1 1 1 2 2 2 0 Pentapeptide repeats (9 copies) SH PF01445.17 ELR11992.1 - 3.2 7.8 13.4 6.8 6.7 0.6 4.2 2 2 3 5 5 5 0 Viral small hydrophobic protein RVT_2 PF07727.14 ELR11993.1 - 4.6e-38 131.2 0.0 5.6e-38 131.0 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) F-box PF00646.33 ELR11994.1 - 0.00024 20.9 0.0 0.00048 19.9 0.0 1.4 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 ELR11994.1 - 0.00093 19.0 0.0 0.0018 18.1 0.0 1.4 1 0 0 1 1 1 1 F-box-like DUF4399 PF14347.6 ELR11994.1 - 0.15 12.5 0.1 0.3 11.5 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4399) DMAP_binding PF06464.11 ELR11994.1 - 1.8 9.4 9.9 0.41 11.5 2.4 2.4 2 0 0 2 2 2 0 DMAP1-binding Domain hNIFK_binding PF12196.8 ELR11994.1 - 8.2 6.0 7.1 3.1 7.3 2.7 2.4 1 1 1 2 2 2 0 FHA Ki67 binding domain of hNIFK HAT PF02184.16 ELR11996.1 - 2.5e-09 36.9 4.8 5.5e-06 26.2 1.4 2.5 2 0 0 2 2 2 2 HAT (Half-A-TPR) repeat TPR_14 PF13428.6 ELR11996.1 - 0.011 16.4 0.8 0.023 15.5 0.1 1.8 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_11 PF13414.6 ELR11996.1 - 0.018 14.7 0.0 0.036 13.7 0.0 1.4 1 0 0 1 1 1 0 TPR repeat TPR_7 PF13176.6 ELR11996.1 - 0.029 14.4 0.1 0.072 13.1 0.1 1.7 1 0 0 1 1 1 0 Tetratricopeptide repeat MRP-L28 PF09812.9 ELR11996.1 - 0.26 11.4 8.0 0.31 11.1 8.0 1.1 1 0 0 1 1 1 0 Mitochondrial ribosomal protein L28 Ras PF00071.22 ELR11997.1 - 4.8e-21 75.0 0.0 7.9e-21 74.3 0.0 1.3 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR11997.1 - 4.9e-14 52.6 0.0 8.3e-14 51.8 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ank_2 PF12796.7 ELR11997.1 - 1.6e-11 44.6 0.6 1.1e-05 25.9 0.2 2.3 1 1 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ELR11997.1 - 1e-10 41.9 1.9 9e-05 23.0 0.2 2.9 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 ELR11997.1 - 1.5e-09 38.0 2.1 2.8e-06 27.5 0.6 2.6 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 ELR11997.1 - 5.7e-07 29.7 0.5 2.2e-05 24.7 0.1 2.8 2 0 0 2 2 2 1 Ankyrin repeat Ank_3 PF13606.6 ELR11997.1 - 3.2e-05 24.0 1.1 2 9.3 0.0 3.8 3 0 0 3 3 3 2 Ankyrin repeat Arf PF00025.21 ELR11997.1 - 0.0001 21.8 0.0 0.00017 21.1 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family F-box-like PF12937.7 ELR11997.1 - 0.0014 18.4 0.1 0.0037 17.1 0.1 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ELR11997.1 - 0.048 13.6 0.9 0.11 12.3 0.9 1.6 1 0 0 1 1 1 0 F-box domain HEAT_EZ PF13513.6 ELR11998.1 - 3.4e-12 46.6 2.3 0.0029 18.1 0.0 6.1 5 1 1 6 6 6 3 HEAT-like repeat HEAT PF02985.22 ELR11998.1 - 1e-07 31.6 7.1 0.17 12.2 0.0 7.2 7 0 0 7 7 7 2 HEAT repeat HEAT_2 PF13646.6 ELR11998.1 - 1.1e-06 28.9 0.3 0.26 11.7 0.0 5.5 3 2 2 5 5 5 1 HEAT repeats CLASP_N PF12348.8 ELR11998.1 - 6.7e-06 25.8 0.7 1.3 8.6 0.0 4.9 4 1 1 5 5 5 2 CLASP N terminal Exo_endo_phos PF03372.23 ELR11998.1 - 0.0026 17.3 0.0 0.013 15.0 0.0 1.9 2 0 0 2 2 2 1 Endonuclease/Exonuclease/phosphatase family Cnd1 PF12717.7 ELR11998.1 - 0.0028 17.7 0.2 0.29 11.2 0.0 3.2 3 1 0 3 3 3 1 non-SMC mitotic condensation complex subunit 1 V-ATPase_H_N PF03224.14 ELR11998.1 - 0.0086 15.4 0.4 0.038 13.3 0.1 2.1 2 1 1 3 3 3 1 V-ATPase subunit H DUF3385 PF11865.8 ELR11998.1 - 0.19 11.6 0.5 2.6 8.0 0.0 2.7 3 1 1 4 4 4 0 Domain of unknown function (DUF3385) P2X_receptor PF00864.19 ELR11999.1 - 6.4e-05 22.2 0.1 0.00031 19.9 0.1 2.0 2 0 0 2 2 2 1 ATP P2X receptor Wound_ind PF08186.11 ELR11999.1 - 0.099 13.1 1.7 0.28 11.6 1.7 1.8 1 0 0 1 1 1 0 Wound-inducible basic protein family Peripla_BP_6 PF13458.6 ELR12000.1 - 1.3e-44 153.3 20.5 2.9e-26 93.0 7.4 2.5 2 1 0 2 2 2 2 Periplasmic binding protein ANF_receptor PF01094.28 ELR12000.1 - 3.9e-24 85.4 0.6 1.3e-12 47.5 0.0 2.2 2 0 0 2 2 2 2 Receptor family ligand binding region Peripla_BP_5 PF13433.6 ELR12000.1 - 0.00025 20.2 0.9 0.023 13.7 0.1 2.2 2 0 0 2 2 2 2 Periplasmic binding protein domain LppC PF04348.13 ELR12000.1 - 0.012 14.4 1.1 0.02 13.7 1.1 1.3 1 0 0 1 1 1 0 LppC putative lipoprotein CcmD PF04995.14 ELR12000.1 - 1.7 8.8 7.0 5.5 7.2 7.0 1.9 1 0 0 1 1 1 0 Heme exporter protein D (CcmD) GST_C_2 PF13410.6 ELR12001.1 - 5.4e-06 26.3 0.1 5.8e-06 26.2 0.1 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 ELR12001.1 - 0.0028 17.8 0.0 0.0072 16.5 0.0 1.7 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 ELR12001.1 - 0.037 14.3 0.0 0.056 13.7 0.0 1.4 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain ATP-synt PF00231.19 ELR12002.1 - 5.8e-47 160.7 1.4 7.9e-47 160.3 1.4 1.0 1 0 0 1 1 1 1 ATP synthase RhoGEF PF00621.20 ELR12003.1 - 2.1e-13 50.9 0.1 3.8e-13 50.1 0.1 1.4 1 0 0 1 1 1 1 RhoGEF domain PH_10 PF15411.6 ELR12003.1 - 0.0025 18.1 0.1 0.0047 17.2 0.1 1.4 1 0 0 1 1 1 1 Pleckstrin homology domain PH_16 PF17838.1 ELR12003.1 - 0.016 15.0 0.0 0.03 14.2 0.0 1.4 1 0 0 1 1 1 0 PH domain PH_13 PF16652.5 ELR12003.1 - 0.085 12.7 0.6 0.12 12.1 0.3 1.5 1 1 0 1 1 1 0 Pleckstrin homology domain DAO PF01266.24 ELR12004.1 - 0.0033 17.1 2.2 0.0049 16.5 2.2 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase Lycopene_cycl PF05834.12 ELR12004.1 - 0.0072 15.4 0.3 0.0076 15.3 0.3 1.2 1 0 0 1 1 1 1 Lycopene cyclase protein Trp_halogenase PF04820.14 ELR12004.1 - 0.0095 14.8 0.3 0.012 14.5 0.3 1.1 1 0 0 1 1 1 1 Tryptophan halogenase Pyr_redox_2 PF07992.14 ELR12004.1 - 0.039 13.2 0.1 0.039 13.2 0.1 1.1 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 ELR12004.1 - 0.054 13.7 1.0 0.089 13.0 1.0 1.3 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain FAD_binding_3 PF01494.19 ELR12004.1 - 0.089 12.0 0.1 0.11 11.7 0.1 1.2 1 0 0 1 1 1 0 FAD binding domain Pyr_redox PF00070.27 ELR12004.1 - 0.12 13.0 0.7 0.16 12.6 0.7 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Myb_Cef PF11831.8 ELR12005.1 - 3.3e-52 177.5 10.7 3.3e-52 177.5 10.7 4.6 4 1 1 5 5 5 1 pre-mRNA splicing factor component Myb_DNA-binding PF00249.31 ELR12005.1 - 5.9e-21 74.4 5.6 2.7e-11 43.5 1.2 2.7 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 ELR12005.1 - 1.6e-18 66.7 3.0 2e-12 47.1 3.3 2.8 1 1 1 2 2 2 2 Myb-like DNA-binding domain PP1_bind PF15276.6 ELR12005.1 - 7.9 6.9 9.3 1.7 9.0 0.1 3.8 4 0 0 4 4 4 0 Protein phosphatase 1 binding RRM_1 PF00076.22 ELR12006.1 - 2.9e-08 33.4 0.0 3.8e-08 33.0 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) NTP_transferase PF00483.23 ELR12007.1 - 2.4e-11 43.7 0.0 3.6e-11 43.1 0.0 1.2 1 0 0 1 1 1 1 Nucleotidyl transferase Hexapep PF00132.24 ELR12007.1 - 5.7e-08 32.2 10.1 2.4e-06 27.0 4.8 3.9 1 1 2 3 3 3 3 Bacterial transferase hexapeptide (six repeats) DUF4954 PF16314.5 ELR12007.1 - 0.0054 14.9 1.2 0.0098 14.1 0.8 1.6 1 1 0 1 1 1 1 Domain of unknown function (DUF4954) Fucokinase PF07959.12 ELR12007.1 - 0.06 12.3 0.4 0.18 10.7 0.4 1.8 1 1 0 1 1 1 0 L-fucokinase Hexapep_2 PF14602.6 ELR12007.1 - 0.11 12.3 7.8 0.63 9.8 1.8 3.5 3 1 0 3 3 3 0 Hexapeptide repeat of succinyl-transferase PhnA PF03831.14 ELR12007.1 - 0.2 11.6 0.4 2 8.3 0.0 2.6 2 0 0 2 2 2 0 PhnA domain RPA_C PF08784.11 ELR12008.1 - 2.5e-08 34.5 0.1 6e-08 33.3 0.0 1.7 2 0 0 2 2 2 1 Replication protein A C terminal tRNA_anti-codon PF01336.25 ELR12008.1 - 3.7e-07 30.0 0.2 6.1e-07 29.3 0.2 1.3 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain RMI2 PF16100.5 ELR12008.1 - 1e-05 25.4 0.2 1.5e-05 24.8 0.2 1.3 1 0 0 1 1 1 1 RecQ-mediated genome instability protein 2 CDC24_OB3 PF17244.2 ELR12008.1 - 0.0058 16.4 0.1 0.01 15.6 0.1 1.3 1 0 0 1 1 1 1 Cell division control protein 24, OB domain 3 FAD_binding_6 PF00970.24 ELR12009.1 - 1.7e-26 92.4 0.0 2.9e-26 91.7 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_1 PF00175.21 ELR12009.1 - 2.3e-20 73.3 0.0 3.7e-20 72.6 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain Cyt-b5 PF00173.28 ELR12009.1 - 4.2e-08 33.2 0.1 9.5e-06 25.7 0.1 2.4 1 1 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain NAD_binding_6 PF08030.12 ELR12009.1 - 2e-07 31.3 0.0 1.2e-06 28.8 0.0 1.9 1 1 0 2 2 2 1 Ferric reductase NAD binding domain HAUS-augmin3 PF14932.6 ELR12010.1 - 0.0025 17.5 7.1 0.0034 17.0 7.1 1.3 1 0 0 1 1 1 1 HAUS augmin-like complex subunit 3 DUF4472 PF14739.6 ELR12010.1 - 0.012 16.3 9.0 0.019 15.7 9.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4472) WDCP PF15390.6 ELR12010.1 - 0.26 9.6 7.8 0.29 9.4 7.8 1.0 1 0 0 1 1 1 0 WD repeat and coiled-coil-containing protein family SpecificRecomb PF10136.9 ELR12010.1 - 0.3 9.3 2.6 0.38 9.0 2.6 1.1 1 0 0 1 1 1 0 Site-specific recombinase UPF0515 PF15135.6 ELR12010.1 - 0.33 10.3 3.0 0.39 10.0 3.0 1.1 1 0 0 1 1 1 0 Uncharacterised protein UPF0515 Allexi_40kDa PF05549.11 ELR12010.1 - 0.34 10.4 4.2 0.43 10.1 4.2 1.2 1 0 0 1 1 1 0 Allexivirus 40kDa protein vATP-synt_E PF01991.18 ELR12010.1 - 0.43 9.9 13.3 0.9 8.9 12.9 1.6 1 1 1 2 2 2 0 ATP synthase (E/31 kDa) subunit DUF1664 PF07889.12 ELR12010.1 - 0.45 10.5 6.0 4.1 7.5 0.3 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Phlebovirus_NSM PF07246.11 ELR12010.1 - 0.49 9.7 8.4 0.66 9.3 8.4 1.2 1 0 0 1 1 1 0 Phlebovirus nonstructural protein NS-M APG6_N PF17675.1 ELR12010.1 - 0.56 10.7 11.2 0.83 10.2 11.2 1.2 1 0 0 1 1 1 0 Apg6 coiled-coil region FapA PF03961.13 ELR12010.1 - 0.65 8.5 8.2 0.78 8.3 8.2 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A FlaC_arch PF05377.11 ELR12010.1 - 0.92 9.9 4.6 9.1 6.8 3.1 2.8 1 1 1 2 2 2 0 Flagella accessory protein C (FlaC) Phage_Mu_Gam PF07352.12 ELR12010.1 - 0.92 9.4 10.9 0.39 10.6 4.8 2.1 1 1 1 2 2 2 0 Bacteriophage Mu Gam like protein XhlA PF10779.9 ELR12010.1 - 1.6 9.0 8.3 11 6.3 0.2 2.4 2 0 0 2 2 2 0 Haemolysin XhlA Uso1_p115_C PF04871.13 ELR12010.1 - 8.2 6.8 13.6 16 5.9 13.6 1.5 1 1 0 1 1 1 0 Uso1 / p115 like vesicle tethering protein, C terminal region RhoGEF PF00621.20 ELR12011.1 - 5e-11 43.2 0.0 1.6e-10 41.5 0.0 1.8 2 0 0 2 2 2 1 RhoGEF domain PH PF00169.29 ELR12011.1 - 0.00057 20.4 0.0 0.0011 19.4 0.0 1.5 1 0 0 1 1 1 1 PH domain IQ_SEC7_PH PF16453.5 ELR12011.1 - 0.0074 16.3 0.0 0.021 14.8 0.0 1.7 1 1 0 1 1 1 1 PH domain PH_13 PF16652.5 ELR12011.1 - 4.7 7.0 5.9 2.2 8.1 0.0 2.8 2 1 0 2 2 2 0 Pleckstrin homology domain DUF1681 PF07933.14 ELR12012.1 - 5.3e-58 194.9 0.0 6.2e-58 194.7 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1681) TPR_12 PF13424.6 ELR12013.1 - 1.5e-08 34.8 0.0 2.7e-08 34.0 0.0 1.4 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_2 PF07719.17 ELR12013.1 - 3.5e-05 23.6 1.8 0.00042 20.2 0.1 2.8 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_7 PF13176.6 ELR12013.1 - 0.00026 20.8 0.1 0.0012 18.7 0.0 2.1 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_1 PF00515.28 ELR12013.1 - 0.00028 20.6 0.2 0.0013 18.5 0.0 2.2 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_10 PF13374.6 ELR12013.1 - 0.0016 18.2 0.0 0.0041 16.9 0.0 1.7 1 0 0 1 1 1 1 Tetratricopeptide repeat DUF2225 PF09986.9 ELR12013.1 - 0.0076 16.0 0.1 0.0088 15.8 0.1 1.1 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2225) TPR_14 PF13428.6 ELR12013.1 - 0.019 15.7 0.1 0.044 14.6 0.1 1.7 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_16 PF13432.6 ELR12013.1 - 0.083 13.6 1.6 0.53 11.0 0.2 2.4 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_11 PF13414.6 ELR12013.1 - 0.13 12.0 0.2 41 4.0 0.4 3.1 3 0 0 3 3 3 0 TPR repeat CH PF00307.31 ELR12014.1 - 7.1e-52 174.2 0.2 5.6e-27 94.1 0.0 2.6 2 0 0 2 2 2 2 Calponin homology (CH) domain CAMSAP_CH PF11971.8 ELR12014.1 - 1.4e-11 44.0 0.0 8.5e-09 35.1 0.0 2.7 3 0 0 3 3 3 2 CAMSAP CH domain EFhand_Ca_insen PF08726.10 ELR12014.1 - 1.6e-07 31.3 0.0 4.8e-07 29.8 0.0 1.9 1 0 0 1 1 1 1 Ca2+ insensitive EF hand EF-hand_1 PF00036.32 ELR12014.1 - 3.1e-07 29.5 0.4 9e-06 24.9 0.4 3.2 3 0 0 3 3 3 1 EF hand EF-hand_6 PF13405.6 ELR12014.1 - 3.4e-05 23.4 0.4 0.00027 20.6 0.3 2.7 2 0 0 2 2 2 1 EF-hand domain EF-hand_7 PF13499.6 ELR12014.1 - 0.0057 17.1 0.4 0.024 15.1 0.4 2.2 1 0 0 1 1 1 1 EF-hand domain pair Spectrin PF00435.21 ELR12014.1 - 0.011 16.2 8.1 0.11 13.0 0.5 3.4 3 0 0 3 3 3 0 Spectrin repeat EF-hand_8 PF13833.6 ELR12014.1 - 0.1 12.5 1.2 0.96 9.3 0.3 3.0 4 0 0 4 4 4 0 EF-hand domain pair OmpH PF03938.14 ELR12014.1 - 0.47 10.8 9.0 0.079 13.3 1.9 2.5 2 1 0 2 2 2 0 Outer membrane protein (OmpH-like) Baculo_PEP_C PF04513.12 ELR12014.1 - 0.77 9.8 3.8 7 6.7 0.7 3.3 3 1 1 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus Apolipoprotein PF01442.18 ELR12014.1 - 5.6 6.8 13.0 1.9e+02 1.8 13.0 2.8 1 1 0 1 1 1 0 Apolipoprotein A1/A4/E domain Pkinase PF00069.25 ELR12015.1 - 1.1e-18 67.5 0.3 1.4e-18 67.2 0.3 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR12015.1 - 2.4e-12 46.7 0.3 3.3e-12 46.3 0.3 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase PyrI PF01948.18 ELR12015.1 - 0.056 13.7 1.1 2 8.7 0.2 2.2 1 1 1 2 2 2 0 Aspartate carbamoyltransferase regulatory chain, allosteric domain Ank_2 PF12796.7 ELR12016.1 - 2.4e-16 60.1 0.4 1.5e-06 28.7 1.1 2.9 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_5 PF13857.6 ELR12016.1 - 2.5e-15 56.3 1.6 8.1e-07 29.2 0.0 3.8 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank PF00023.30 ELR12016.1 - 8.7e-12 44.9 0.2 0.11 13.0 0.0 4.3 4 0 0 4 4 4 4 Ankyrin repeat Ank_4 PF13637.6 ELR12016.1 - 5.5e-09 36.4 0.3 0.0052 17.3 0.1 3.6 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 ELR12016.1 - 4.6e-08 32.7 0.5 0.075 13.6 0.0 4.0 4 1 0 4 4 4 2 Ankyrin repeat PTS_IIA PF02255.16 ELR12016.1 - 0.23 11.5 5.1 0.73 9.9 5.1 1.8 1 1 0 1 1 1 0 PTS system, Lactose/Cellobiose specific IIA subunit PARP_reg PF02877.14 ELR12017.1 - 5.5e-31 107.5 1.6 2.6e-30 105.3 1.6 2.0 1 1 0 1 1 1 1 Poly(ADP-ribose) polymerase, regulatory domain PARP PF00644.20 ELR12017.1 - 2.5e-05 24.0 0.1 2.5e-05 24.0 0.1 2.2 3 0 0 3 3 3 1 Poly(ADP-ribose) polymerase catalytic domain ANAPC15 PF15243.6 ELR12017.1 - 0.0023 18.3 9.1 0.006 16.9 9.1 1.8 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 15 NOA36 PF06524.12 ELR12017.1 - 0.0078 15.6 6.1 0.012 15.0 6.1 1.2 1 0 0 1 1 1 1 NOA36 protein KBP_C PF12309.8 ELR12017.1 - 0.01 15.4 3.5 0.01 15.4 1.7 1.9 2 0 0 2 2 2 1 KIF-1 binding protein C terminal CobT PF06213.12 ELR12017.1 - 0.021 14.2 10.7 0.038 13.4 10.7 1.3 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT CDC45 PF02724.14 ELR12017.1 - 0.048 11.9 6.1 0.069 11.4 6.1 1.2 1 0 0 1 1 1 0 CDC45-like protein DNA_pol_phi PF04931.13 ELR12017.1 - 0.086 10.9 8.4 0.11 10.5 8.4 1.2 1 0 0 1 1 1 0 DNA polymerase phi FAM176 PF14851.6 ELR12017.1 - 0.088 12.5 4.9 0.2 11.3 4.9 1.6 1 0 0 1 1 1 0 FAM176 family RR_TM4-6 PF06459.12 ELR12017.1 - 0.089 12.6 8.9 0.14 12.0 8.9 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF2457 PF10446.9 ELR12017.1 - 0.12 11.5 12.1 0.2 10.7 12.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) TFB6 PF17110.5 ELR12017.1 - 0.17 11.6 3.0 0.41 10.4 3.0 1.7 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH DUF4471 PF14740.6 ELR12017.1 - 0.29 10.3 2.9 0.16 11.2 0.9 1.5 1 1 1 2 2 2 0 Domain of unknown function (DUF4471) DUF4611 PF15387.6 ELR12017.1 - 0.4 10.9 13.2 0.061 13.5 8.5 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4611) CDC27 PF09507.10 ELR12017.1 - 0.42 9.9 13.8 0.59 9.5 13.8 1.2 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 HABP4_PAI-RBP1 PF04774.15 ELR12017.1 - 0.49 11.3 14.8 0.13 13.1 10.9 2.0 2 0 0 2 2 2 0 Hyaluronan / mRNA binding family TMEM119 PF15724.5 ELR12017.1 - 0.59 10.1 4.3 0.93 9.5 4.3 1.2 1 0 0 1 1 1 0 TMEM119 family PBP1_TM PF14812.6 ELR12017.1 - 0.73 10.2 12.9 0.12 12.8 7.7 2.3 3 0 0 3 3 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal RP-C_C PF11800.8 ELR12017.1 - 0.8 9.8 6.8 0.27 11.3 2.8 2.1 2 0 0 2 2 2 0 Replication protein C C-terminal region PTPRCAP PF15713.5 ELR12017.1 - 1.1 9.5 12.3 0.21 11.9 8.4 1.7 2 0 0 2 2 2 0 Protein tyrosine phosphatase receptor type C-associated DUF2203 PF09969.9 ELR12017.1 - 1.2 9.8 4.7 13 6.5 2.7 2.7 2 1 0 2 2 2 0 Uncharacterized conserved protein (DUF2203) Astro_capsid_p PF12226.8 ELR12017.1 - 1.8 7.6 7.9 0.21 10.7 3.9 1.5 2 0 0 2 2 2 0 Turkey astrovirus capsid protein CENP-B_dimeris PF09026.10 ELR12017.1 - 1.8 9.0 15.6 4.8 7.6 15.6 1.6 1 0 0 1 1 1 0 Centromere protein B dimerisation domain PIEZO PF15917.5 ELR12017.1 - 8.9 5.7 7.2 0.7 9.3 1.7 1.9 3 0 0 3 3 3 0 Piezo SAM_2 PF07647.17 ELR12018.1 - 1.3e-08 34.8 0.0 1.7e-08 34.5 0.0 1.2 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 ELR12018.1 - 3e-07 30.8 0.0 4.2e-07 30.3 0.0 1.2 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) TPR_8 PF13181.6 ELR12019.1 - 0.013 15.6 0.5 0.04 14.1 0.5 1.8 1 0 0 1 1 1 0 Tetratricopeptide repeat DUF4746 PF15928.5 ELR12019.1 - 0.081 12.3 0.2 0.11 11.9 0.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) CHMI PF02962.15 ELR12019.1 - 0.15 12.4 0.0 0.32 11.3 0.0 1.6 1 0 0 1 1 1 0 5-carboxymethyl-2-hydroxymuconate isomerase Fascin PF06268.13 ELR12020.1 - 1.1e-11 44.9 0.1 0.024 14.9 0.0 5.8 3 2 2 5 5 5 3 Fascin domain RicinB_lectin_2 PF14200.6 ELR12020.1 - 0.0081 16.9 0.0 0.041 14.6 0.0 2.1 2 0 0 2 2 2 1 Ricin-type beta-trefoil lectin domain-like GRAM PF02893.20 ELR12020.1 - 0.089 12.7 0.0 0.2 11.6 0.0 1.6 1 0 0 1 1 1 0 GRAM domain Myotub-related PF06602.14 ELR12021.1 - 2.8e-50 171.2 3.2 3.3e-50 171.0 3.2 1.1 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain zf-MYND PF01753.18 ELR12022.1 - 1.9e-06 27.8 8.8 1.9e-06 27.8 8.8 1.7 2 0 0 2 2 2 1 MYND finger zf-C6H2 PF15801.5 ELR12022.1 - 6.7e-05 23.1 8.7 0.00013 22.2 8.7 1.4 1 0 0 1 1 1 1 zf-MYND-like zinc finger, mRNA-binding MMR_HSR1 PF01926.23 ELR12024.1 - 3.1e-07 30.5 0.0 6.1e-07 29.5 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase Zn_Tnp_IS1595 PF12760.7 ELR12024.1 - 2.2e-05 24.3 1.5 4.7e-05 23.3 1.5 1.5 1 0 0 1 1 1 1 Transposase zinc-ribbon domain AAA_16 PF13191.6 ELR12024.1 - 0.00027 21.4 0.0 0.00053 20.4 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain RsgA_GTPase PF03193.16 ELR12024.1 - 0.00047 20.1 0.0 0.0089 15.9 0.0 2.4 2 0 0 2 2 2 1 RsgA GTPase Septin PF00735.18 ELR12024.1 - 0.00065 19.1 0.0 0.87 8.8 0.0 2.3 2 0 0 2 2 2 2 Septin AAA_29 PF13555.6 ELR12024.1 - 0.0022 17.7 0.0 0.0048 16.6 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AIG1 PF04548.16 ELR12024.1 - 0.0028 17.0 0.0 0.0051 16.2 0.0 1.5 1 0 0 1 1 1 1 AIG1 family Dynamin_N PF00350.23 ELR12024.1 - 0.004 17.2 0.0 0.018 15.1 0.0 1.8 1 1 1 2 2 2 1 Dynamin family AAA_33 PF13671.6 ELR12024.1 - 0.0043 17.2 0.0 0.0094 16.1 0.0 1.5 1 0 0 1 1 1 1 AAA domain ABC_tran PF00005.27 ELR12024.1 - 0.0072 16.8 0.0 0.015 15.8 0.0 1.6 1 0 0 1 1 1 1 ABC transporter SRPRB PF09439.10 ELR12024.1 - 0.011 15.2 0.0 0.021 14.2 0.0 1.4 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit T2SSE PF00437.20 ELR12024.1 - 0.011 14.8 0.0 0.024 13.7 0.0 1.5 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_23 PF13476.6 ELR12024.1 - 0.011 16.2 0.0 0.025 15.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 ELR12024.1 - 0.018 15.6 0.0 0.033 14.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain IIGP PF05049.13 ELR12024.1 - 0.019 14.0 0.0 0.033 13.2 0.0 1.3 1 0 0 1 1 1 0 Interferon-inducible GTPase (IIGP) TackOD1 PF18551.1 ELR12024.1 - 0.019 14.6 0.1 0.037 13.7 0.1 1.4 1 0 0 1 1 1 0 Thaumarchaeal output domain 1 zf-TFIIB PF13453.6 ELR12024.1 - 0.049 13.0 1.5 0.094 12.1 1.5 1.4 1 0 0 1 1 1 0 Transcription factor zinc-finger AAA_22 PF13401.6 ELR12024.1 - 0.051 13.8 0.1 0.15 12.3 0.1 1.9 1 1 0 1 1 1 0 AAA domain Fumarate_red_D PF02313.17 ELR12024.1 - 0.059 13.5 1.8 0.086 12.9 0.0 2.1 2 0 0 2 2 2 0 Fumarate reductase subunit D AAA_7 PF12775.7 ELR12024.1 - 0.1 12.1 0.0 0.19 11.2 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region ATP_bind_1 PF03029.17 ELR12024.1 - 0.11 12.2 0.0 0.69 9.7 0.1 2.0 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein Gtr1_RagA PF04670.12 ELR12024.1 - 0.12 11.7 0.0 0.19 11.0 0.0 1.3 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region PhnA_Zn_Ribbon PF08274.12 ELR12024.1 - 0.16 12.0 0.2 0.32 11.0 0.2 1.5 1 0 0 1 1 1 0 PhnA Zinc-Ribbon PduV-EutP PF10662.9 ELR12024.1 - 0.18 11.5 0.3 1.6 8.5 0.0 2.4 3 0 0 3 3 3 0 Ethanolamine utilisation - propanediol utilisation EcsC PF12787.7 ELR12024.1 - 0.21 11.2 0.4 4.9 6.7 0.0 2.3 2 0 0 2 2 2 0 EcsC protein family HalOD2 PF18547.1 ELR12024.1 - 2.7 8.0 5.2 0.66 9.9 0.5 2.2 2 0 0 2 2 2 0 Halobacterial output domain 2 GTP_EFTU PF00009.27 ELR12025.1 - 1.8e-57 194.0 0.0 2.5e-57 193.6 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_C PF00679.24 ELR12025.1 - 3.3e-20 71.9 0.0 7e-20 70.9 0.0 1.5 1 0 0 1 1 1 1 Elongation factor G C-terminus EFG_II PF14492.6 ELR12025.1 - 5.1e-17 61.7 0.0 9.9e-17 60.8 0.0 1.5 1 0 0 1 1 1 1 Elongation Factor G, domain II GTP_EFTU_D2 PF03144.25 ELR12025.1 - 7.6e-10 39.0 0.0 2.4e-09 37.4 0.0 1.9 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 ELR12025.1 - 0.0013 18.8 0.0 0.003 17.6 0.0 1.6 1 1 0 1 1 1 1 50S ribosome-binding GTPase RF3_C PF16658.5 ELR12025.1 - 0.17 11.7 0.0 0.34 10.7 0.0 1.4 1 0 0 1 1 1 0 Class II release factor RF3, C-terminal domain Kin17_mid PF10357.9 ELR12026.1 - 1.3e-48 164.1 0.5 1.3e-48 164.1 0.5 2.6 3 0 0 3 3 3 1 Domain of Kin17 curved DNA-binding protein KN17_SH3 PF18131.1 ELR12026.1 - 7.6e-14 51.6 2.8 9.1e-12 44.9 2.1 2.3 2 0 0 2 2 2 1 KN17 SH3-like C-terminal domain SR-25 PF10500.9 ELR12026.1 - 0.00047 19.9 23.3 0.00047 19.9 23.3 2.0 2 0 0 2 2 2 1 Nuclear RNA-splicing-associated protein zf-C2H2_jaz PF12171.8 ELR12026.1 - 0.0089 16.3 5.9 0.018 15.3 5.9 1.5 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 ELR12026.1 - 0.023 15.1 6.3 0.023 15.1 6.3 1.8 2 0 0 2 2 2 0 Zinc-finger of C2H2 type PA26 PF04636.13 ELR12026.1 - 0.1 11.5 4.9 0.2 10.6 4.9 1.5 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) CCSAP PF15748.5 ELR12026.1 - 0.27 11.4 25.0 0.21 11.7 12.2 2.2 2 0 0 2 2 2 0 Centriole, cilia and spindle-associated KOW PF00467.29 ELR12026.1 - 0.48 10.5 3.6 0.93 9.5 0.0 3.0 3 0 0 3 3 3 0 KOW motif SOBP PF15279.6 ELR12026.1 - 0.81 10.2 5.7 1.5 9.4 5.7 1.5 1 0 0 1 1 1 0 Sine oculis-binding protein DUF629 PF04780.12 ELR12026.1 - 2 6.8 10.6 0.88 8.0 1.9 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF629) APG6_N PF17675.1 ELR12026.1 - 3.1 8.3 21.8 0.74 10.3 1.1 2.7 3 0 0 3 3 3 0 Apg6 coiled-coil region Ndc1_Nup PF09531.10 ELR12026.1 - 6.8 5.3 6.1 9.5 4.8 6.1 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup p450 PF00067.22 ELR12027.1 - 1.3e-88 297.8 0.0 2e-60 204.9 0.0 3.0 1 1 2 3 3 3 3 Cytochrome P450 SDA1 PF05285.12 ELR12029.1 - 0.017 14.5 8.9 0.02 14.3 8.9 1.2 1 0 0 1 1 1 0 SDA1 P3A PF08727.11 ELR12029.1 - 0.11 11.9 1.3 2 7.9 1.6 2.5 1 1 1 2 2 2 0 Poliovirus 3A protein like MecA PF05389.12 ELR12030.1 - 0.00055 19.6 0.6 0.00058 19.6 0.6 1.1 1 0 0 1 1 1 1 Negative regulator of genetic competence (MecA) DUF5048 PF16467.5 ELR12030.1 - 0.044 14.1 0.1 0.064 13.5 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF5048) RVT_2 PF07727.14 ELR12031.1 - 3.2e-41 141.6 0.1 1.1e-39 136.6 0.1 2.2 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 ELR12031.1 - 1.9e-12 47.4 0.1 3.4e-11 43.4 0.0 3.0 3 1 0 3 3 3 1 Integrase core domain gag_pre-integrs PF13976.6 ELR12031.1 - 3.4e-06 26.8 0.0 9e-06 25.5 0.0 1.7 1 0 0 1 1 1 1 GAG-pre-integrase domain RVT_3 PF13456.6 ELR12031.1 - 0.047 13.5 0.0 0.11 12.3 0.0 1.6 1 0 0 1 1 1 0 Reverse transcriptase-like rve_3 PF13683.6 ELR12031.1 - 0.34 10.7 0.0 0.34 10.7 0.0 2.1 2 0 0 2 2 2 0 Integrase core domain Retrotran_gag_2 PF14223.6 ELR12032.1 - 2.7e-07 30.3 0.1 4.8e-07 29.5 0.1 1.4 1 0 0 1 1 1 1 gag-polypeptide of LTR copia-type Nha1_C PF08619.10 ELR12033.1 - 0.021 14.1 2.1 0.027 13.7 2.1 1.2 1 0 0 1 1 1 0 Alkali metal cation/H+ antiporter Nha1 C terminus Glyco_hydro_53 PF07745.13 ELR12033.1 - 0.033 13.2 0.2 0.064 12.2 0.2 1.4 1 0 0 1 1 1 0 Glycosyl hydrolase family 53 ACOX PF01756.19 ELR12034.1 - 2.7e-37 128.1 0.9 4.6e-37 127.3 0.0 1.7 2 0 0 2 2 2 1 Acyl-CoA oxidase Acyl-CoA_ox_N PF14749.6 ELR12034.1 - 6.9e-17 62.2 1.1 7.1e-16 58.9 0.2 2.2 2 0 0 2 2 2 1 Acyl-coenzyme A oxidase N-terminal Acyl-CoA_dh_M PF02770.19 ELR12034.1 - 1.4e-13 50.8 0.1 2.6e-13 50.0 0.1 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Spectrin PF00435.21 ELR12035.1 - 0.011 16.2 1.3 0.011 16.2 1.3 2.9 4 0 0 4 4 4 0 Spectrin repeat CENP-F_leu_zip PF10473.9 ELR12035.1 - 0.021 14.9 1.6 0.021 14.9 1.6 1.9 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 PAS_3 PF08447.12 ELR12035.1 - 0.021 15.1 0.0 0.07 13.4 0.0 1.9 1 0 0 1 1 1 0 PAS fold YabA PF06156.13 ELR12035.1 - 0.025 15.2 1.1 0.025 15.2 1.1 2.4 2 0 0 2 2 2 0 Initiation control protein YabA DUF3450 PF11932.8 ELR12035.1 - 0.03 13.6 0.2 0.03 13.6 0.2 3.1 3 1 0 3 3 3 0 Protein of unknown function (DUF3450) Herpes_UL6 PF01763.16 ELR12035.1 - 0.11 10.9 1.4 0.12 10.8 0.0 1.7 2 0 0 2 2 2 0 Herpesvirus UL6 like Kinesin_assoc PF16183.5 ELR12035.1 - 0.23 11.6 8.4 1.7 8.8 1.5 3.0 2 1 0 2 2 2 0 Kinesin-associated DUF948 PF06103.11 ELR12035.1 - 0.23 11.7 1.0 0.54 10.6 1.0 1.5 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF948) Mitofilin PF09731.9 ELR12035.1 - 1.5 7.6 10.5 0.022 13.6 0.4 2.5 3 0 0 3 3 3 0 Mitochondrial inner membrane protein ROK PF00480.20 ELR12036.1 - 3.9e-45 154.6 0.0 1.2e-44 153.0 0.0 1.6 1 1 0 1 1 1 1 ROK family Clat_adaptor_s PF01217.20 ELR12037.1 - 1.4e-19 70.4 0.0 1.8e-19 70.1 0.0 1.1 1 0 0 1 1 1 1 Clathrin adaptor complex small chain TrmO PF01980.16 ELR12038.1 - 1.5e-45 154.2 0.0 2.3e-45 153.7 0.0 1.3 1 0 0 1 1 1 1 tRNA-methyltransferase O TrmO_C PF18389.1 ELR12038.1 - 0.00016 21.7 0.0 0.00036 20.6 0.0 1.6 1 0 0 1 1 1 1 TrmO C-terminal domain MYO10_CC PF16735.5 ELR12038.1 - 0.011 15.9 1.5 0.011 15.9 1.5 2.7 3 1 0 3 3 3 0 Unconventional myosin-X coiled coil domain NCBP3 PF10309.9 ELR12038.1 - 0.18 11.7 0.0 0.59 10.0 0.0 1.8 2 0 0 2 2 2 0 Nuclear cap-binding protein subunit 3 RhoGAP PF00620.27 ELR12039.1 - 7.7e-28 97.2 0.0 1.2e-27 96.6 0.0 1.3 1 0 0 1 1 1 1 RhoGAP domain WW PF00397.26 ELR12039.1 - 5.3e-25 87.2 15.4 1.8e-08 34.3 2.7 3.5 3 0 0 3 3 3 3 WW domain MyTH4 PF00784.17 ELR12039.1 - 3.2e-20 72.6 0.0 6.6e-20 71.6 0.0 1.6 1 0 0 1 1 1 1 MyTH4 domain Glyco_hyd_101C PF17451.2 ELR12039.1 - 0.52 10.6 7.1 0.35 11.1 1.5 2.9 2 1 1 3 3 3 0 Glycosyl hydrolase 101 beta sandwich domain Syja_N PF02383.18 ELR12040.1 - 8.1e-14 51.6 0.0 7.9e-12 45.1 0.0 2.0 1 1 1 2 2 2 2 SacI homology domain Syja_N PF02383.18 ELR12041.1 - 0.001 18.5 0.0 0.0017 17.7 0.0 1.3 1 0 0 1 1 1 1 SacI homology domain FYVE PF01363.21 ELR12041.1 - 0.0018 18.4 7.8 0.0036 17.4 7.8 1.4 1 0 0 1 1 1 1 FYVE zinc finger FYVE_2 PF02318.16 ELR12041.1 - 0.019 15.2 2.9 0.041 14.1 2.9 1.6 1 0 0 1 1 1 0 FYVE-type zinc finger CH PF00307.31 ELR12042.1 - 2.7e-39 133.7 0.2 1.4e-19 70.3 0.0 2.2 2 0 0 2 2 2 2 Calponin homology (CH) domain CAMSAP_CH PF11971.8 ELR12042.1 - 9.3e-14 51.0 0.1 1.4e-06 28.1 0.0 2.5 2 0 0 2 2 2 2 CAMSAP CH domain CH_2 PF06294.11 ELR12042.1 - 0.017 15.3 0.0 0.061 13.5 0.0 2.0 2 0 0 2 2 2 0 CH-like domain in sperm protein PATR PF12951.7 ELR12044.1 - 5 7.3 8.4 1.7 8.8 0.6 3.1 3 0 0 3 3 3 0 Passenger-associated-transport-repeat AAA_26 PF13500.6 ELR12046.1 - 1.9e-23 83.3 0.0 2.7e-23 82.8 0.0 1.2 1 0 0 1 1 1 1 AAA domain CbiA PF01656.23 ELR12046.1 - 1.6e-05 25.0 0.0 0.00012 22.1 0.0 2.1 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain CLP_protease PF00574.23 ELR12046.1 - 0.067 13.1 0.0 0.11 12.4 0.0 1.2 1 0 0 1 1 1 0 Clp protease AAA_16 PF13191.6 ELR12046.1 - 0.21 11.9 0.3 0.7 10.3 0.0 2.1 1 1 1 2 2 2 0 AAA ATPase domain WD40 PF00400.32 ELR12047.1 - 4.5e-12 46.3 3.3 8.3e-06 26.5 0.1 5.1 6 0 0 6 6 6 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ELR12047.1 - 1.5e-10 41.3 0.0 0.022 15.0 0.0 4.4 1 1 4 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain PH PF00169.29 ELR12048.1 - 1.2e-16 61.1 0.0 1.9e-16 60.5 0.0 1.3 1 0 0 1 1 1 1 PH domain PH_11 PF15413.6 ELR12048.1 - 2.8e-06 27.7 0.2 0.00049 20.5 0.2 2.4 1 1 0 1 1 1 1 Pleckstrin homology domain PH_6 PF15406.6 ELR12048.1 - 0.0036 17.6 0.0 0.0046 17.2 0.0 1.2 1 0 0 1 1 1 1 Pleckstrin homology domain PH_9 PF15410.6 ELR12048.1 - 0.0065 16.8 0.1 0.9 9.9 0.0 2.3 1 1 1 2 2 2 2 Pleckstrin homology domain PH_8 PF15409.6 ELR12048.1 - 0.091 13.0 0.0 0.16 12.3 0.0 1.4 1 0 0 1 1 1 0 Pleckstrin homology domain DOMON PF03351.17 ELR12049.1 - 1.1e-37 129.0 5.4 7.8e-22 77.8 0.8 2.9 3 0 0 3 3 3 2 DOMON domain Cytochrom_B561 PF03188.16 ELR12049.1 - 1.9e-08 34.6 9.1 5.7e-08 33.0 9.1 1.9 1 0 0 1 1 1 1 Eukaryotic cytochrome b561 DUF1077 PF06417.12 ELR12050.1 - 4e-34 117.2 0.4 5.3e-34 116.7 0.4 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1077) Fibrillarin PF01269.17 ELR12051.1 - 7.4e-109 362.2 0.1 8.5e-109 362.0 0.1 1.0 1 0 0 1 1 1 1 Fibrillarin GCD14 PF08704.10 ELR12051.1 - 1.6e-06 28.0 0.0 2.5e-06 27.4 0.0 1.2 1 0 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit PCMT PF01135.19 ELR12051.1 - 0.0039 17.0 0.1 0.0086 15.8 0.1 1.5 1 1 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltr_RsmB-F PF01189.17 ELR12051.1 - 0.04 13.5 0.0 0.1 12.2 0.0 1.7 1 1 0 1 1 1 0 16S rRNA methyltransferase RsmB/F FtsJ PF01728.19 ELR12051.1 - 0.19 11.8 0.1 0.55 10.3 0.1 1.7 1 1 0 1 1 1 0 FtsJ-like methyltransferase DHHC PF01529.20 ELR12052.1 - 3.4e-28 98.4 13.2 1.3e-27 96.5 13.2 1.9 1 1 0 1 1 1 1 DHHC palmitoyltransferase ubiquitin PF00240.23 ELR12053.1 - 1.9e-11 43.5 0.0 3.4e-11 42.7 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin family UQ_con PF00179.26 ELR12053.1 - 7.8e-10 38.5 0.0 1.3e-09 37.9 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Rad60-SLD_2 PF13881.6 ELR12053.1 - 0.028 14.5 0.0 0.076 13.1 0.0 1.7 2 0 0 2 2 2 0 Ubiquitin-2 like Rad60 SUMO-like Rad60-SLD PF11976.8 ELR12053.1 - 0.054 13.3 0.0 0.086 12.7 0.0 1.3 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like DUF218 PF02698.17 ELR12054.1 - 5.2e-22 78.3 0.0 4.6e-20 72.0 0.0 2.2 1 1 0 1 1 1 1 DUF218 domain Longin PF13774.6 ELR12055.1 - 4.9e-08 32.9 0.0 7.8e-08 32.2 0.0 1.3 1 0 0 1 1 1 1 Regulated-SNARE-like domain Synaptobrevin PF00957.21 ELR12055.1 - 0.00098 18.9 0.2 0.0018 18.0 0.2 1.4 1 0 0 1 1 1 1 Synaptobrevin SH2 PF00017.24 ELR12056.1 - 2e-06 27.8 0.0 3.8e-06 26.9 0.0 1.4 1 0 0 1 1 1 1 SH2 domain DAGK_acc PF00609.19 ELR12057.1 - 6.7e-09 36.3 0.0 1.3e-08 35.3 0.0 1.4 1 0 0 1 1 1 1 Diacylglycerol kinase accessory domain PH PF00169.29 ELR12058.1 - 1e-42 144.9 1.3 1.6e-14 54.3 0.0 3.4 3 0 0 3 3 3 3 PH domain Ank_4 PF13637.6 ELR12058.1 - 1.3e-26 92.6 0.3 4e-11 43.2 0.1 4.6 2 2 2 4 4 4 4 Ankyrin repeats (many copies) Ank_2 PF12796.7 ELR12058.1 - 1.6e-26 92.7 0.7 8.7e-10 39.1 0.0 3.0 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_5 PF13857.6 ELR12058.1 - 5.4e-23 80.8 1.2 2.8e-09 37.0 0.1 3.5 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.30 ELR12058.1 - 2.6e-17 62.4 0.7 0.00023 21.4 0.0 5.7 5 0 0 5 5 5 4 Ankyrin repeat Ank_3 PF13606.6 ELR12058.1 - 5.9e-17 60.0 0.4 0.0019 18.5 0.0 5.7 6 0 0 6 6 6 3 Ankyrin repeat PH_11 PF15413.6 ELR12058.1 - 8.3e-11 42.3 5.4 0.0018 18.7 0.2 5.2 3 2 0 3 3 3 3 Pleckstrin homology domain PH_9 PF15410.6 ELR12058.1 - 2.6e-06 27.8 0.6 0.5 10.8 0.0 4.6 3 2 0 3 3 3 2 Pleckstrin homology domain PH_8 PF15409.6 ELR12058.1 - 5.5e-05 23.4 0.4 0.0079 16.5 0.1 2.9 2 0 0 2 2 2 1 Pleckstrin homology domain Citrus_P18 PF05520.11 ELR12058.1 - 0.15 11.7 0.0 0.28 10.9 0.0 1.3 1 0 0 1 1 1 0 Citrus tristeza virus P18 protein PH PF00169.29 ELR12059.1 - 1.1e-16 61.2 0.0 2.6e-16 60.0 0.0 1.7 1 0 0 1 1 1 1 PH domain Pex24p PF06398.11 ELR12059.1 - 1.4e-13 50.6 2.6 1.9e-13 50.1 2.6 1.1 1 0 0 1 1 1 1 Integral peroxisomal membrane peroxin PRT_C PF08372.10 ELR12059.1 - 1.4e-08 34.7 1.1 2.3e-07 30.7 0.1 2.2 2 0 0 2 2 2 1 Plant phosphoribosyltransferase C-terminal C2 PF00168.30 ELR12059.1 - 3.1e-05 24.2 0.0 5.9e-05 23.3 0.0 1.5 1 0 0 1 1 1 1 C2 domain Reticulon PF02453.17 ELR12059.1 - 0.00084 19.3 3.4 0.053 13.5 1.5 2.4 2 0 0 2 2 2 2 Reticulon PH_9 PF15410.6 ELR12059.1 - 0.0017 18.7 0.1 0.01 16.2 0.1 2.2 1 1 0 1 1 1 1 Pleckstrin homology domain DUF2608 PF11019.8 ELR12059.1 - 0.087 12.3 0.3 0.15 11.6 0.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2608) Halogen_Hydrol PF10112.9 ELR12059.1 - 0.21 11.6 2.9 0.36 10.8 0.1 2.1 2 0 0 2 2 2 0 5-bromo-4-chloroindolyl phosphate hydrolysis protein PhoR PF11808.8 ELR12059.1 - 1.1 9.7 3.3 3 8.3 0.1 2.5 2 1 0 2 2 2 0 Phosphate regulon sensor protein PhoR HATPase_c PF02518.26 ELR12060.1 - 2.6e-23 82.7 0.1 1.1e-22 80.7 0.0 2.2 2 1 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 ELR12060.1 - 2.4e-18 65.9 0.6 8.5e-18 64.2 0.6 2.0 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain Response_reg PF00072.24 ELR12060.1 - 1.9e-15 57.0 0.1 1.2e-13 51.2 0.1 3.2 2 1 0 2 2 2 1 Response regulator receiver domain PAS_8 PF13188.7 ELR12060.1 - 0.035 14.1 0.0 0.15 12.1 0.0 2.1 1 0 0 1 1 1 0 PAS domain HATPase_c_3 PF13589.6 ELR12060.1 - 0.11 12.4 1.9 0.4 10.5 0.0 2.8 2 1 1 3 3 3 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DUF5634 PF18681.1 ELR12060.1 - 0.25 11.7 0.9 11 6.5 0.0 2.7 2 0 0 2 2 2 0 Family of unknown function (DUF5634) FlgN PF05130.12 ELR12060.1 - 0.7 10.4 8.0 0.11 13.0 0.5 2.8 3 0 0 3 3 3 0 FlgN protein WD40 PF00400.32 ELR12061.1 - 1.6e-17 63.5 8.5 1.4e-05 25.7 0.0 6.6 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ELR12061.1 - 3e-08 33.8 0.0 0.19 12.1 0.0 4.9 2 1 3 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ELR12061.1 - 6.2e-05 22.5 0.0 0.00047 19.6 0.0 2.0 2 0 0 2 2 2 1 WD40-like domain Nup160 PF11715.8 ELR12061.1 - 0.02 13.5 0.4 0.15 10.7 0.0 2.2 2 0 0 2 2 2 0 Nucleoporin Nup120/160 ThiJ_like PF17124.5 ELR12061.1 - 0.13 11.9 0.0 0.27 10.9 0.0 1.5 1 0 0 1 1 1 0 ThiJ/PfpI family-like Topoisom_bac PF01131.20 ELR12062.1 - 4.6e-97 325.6 5.2 6e-97 325.3 0.0 3.3 2 1 0 2 2 2 1 DNA topoisomerase Toprim_Crpt PF13342.6 ELR12062.1 - 6.4e-19 67.7 0.1 1.6e-18 66.4 0.1 1.7 1 0 0 1 1 1 1 C-terminal repeat of topoisomerase Toprim PF01751.22 ELR12062.1 - 6.6e-14 52.0 0.0 1.6e-13 50.8 0.0 1.7 1 0 0 1 1 1 1 Toprim domain SAP PF02037.27 ELR12062.1 - 4.4e-12 45.5 1.5 1.2e-11 44.1 1.5 1.8 1 0 0 1 1 1 1 SAP domain Anti-TRAP PF15777.5 ELR12062.1 - 0.31 11.0 1.5 0.68 9.9 0.0 2.3 2 0 0 2 2 2 0 Tryptophan RNA-binding attenuator protein inhibitory protein Pkinase_Tyr PF07714.17 ELR12064.1 - 3.4e-115 383.7 0.0 2.7e-57 194.0 0.0 3.1 3 0 0 3 3 3 3 Protein tyrosine kinase Pkinase PF00069.25 ELR12064.1 - 3e-97 325.1 0.0 1.8e-48 165.2 0.0 3.1 3 0 0 3 3 3 3 Protein kinase domain 5_nucleotid_C PF02872.18 ELR12064.1 - 1.2e-25 90.6 0.0 2.1e-25 89.8 0.0 1.4 1 0 0 1 1 1 1 5'-nucleotidase, C-terminal domain Kinase-like PF14531.6 ELR12064.1 - 1.3e-07 31.2 0.0 0.0048 16.2 0.0 2.5 2 0 0 2 2 2 2 Kinase-like Pkinase_fungal PF17667.1 ELR12064.1 - 1.4e-07 30.6 0.0 0.0096 14.7 0.0 2.2 2 0 0 2 2 2 2 Fungal protein kinase APH PF01636.23 ELR12064.1 - 2.2e-07 31.1 0.2 0.00047 20.1 0.1 2.6 2 0 0 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.14 ELR12064.1 - 3.7e-05 23.2 0.1 0.028 13.8 0.0 2.3 2 0 0 2 2 2 2 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 ELR12064.1 - 0.0021 17.7 0.1 1.4 8.5 0.1 2.3 2 0 0 2 2 2 2 RIO1 family FTA2 PF13095.6 ELR12064.1 - 0.0096 15.6 0.0 0.3 10.7 0.0 2.5 3 0 0 3 3 3 1 Kinetochore Sim4 complex subunit FTA2 Haspin_kinase PF12330.8 ELR12064.1 - 0.18 10.7 0.1 27 3.5 0.0 2.7 3 0 0 3 3 3 0 Haspin like kinase domain EB PF01683.18 ELR12064.1 - 3 8.2 13.1 1.2 9.5 4.8 2.6 2 0 0 2 2 2 0 EB module EGF_2 PF07974.13 ELR12064.1 - 4.2 7.8 13.0 0.13 12.7 6.0 2.2 2 0 0 2 2 1 0 EGF-like domain Sporozoite_P67 PF05642.11 ELR12064.1 - 8.5 4.3 8.5 0.11 10.6 0.8 1.6 2 0 0 2 2 2 0 Sporozoite P67 surface antigen IU_nuc_hydro PF01156.19 ELR12065.1 - 7.8e-42 143.9 0.0 1e-41 143.5 0.0 1.1 1 0 0 1 1 1 1 Inosine-uridine preferring nucleoside hydrolase Glyco_trans_1_4 PF13692.6 ELR12066.1 - 1.2e-14 54.9 0.0 3e-14 53.6 0.0 1.7 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.6 ELR12066.1 - 9.7e-06 26.1 3.7 1.8e-05 25.2 0.3 2.9 2 2 0 2 2 2 1 Glycosyl transferase 4-like domain Glyco_transf_4 PF13439.6 ELR12066.1 - 0.00015 21.8 1.1 0.0012 18.9 0.1 2.7 2 1 0 2 2 2 1 Glycosyltransferase Family 4 Glyco_trans_4_2 PF13477.6 ELR12066.1 - 0.19 11.7 0.0 0.44 10.6 0.0 1.5 1 0 0 1 1 1 0 Glycosyl transferase 4-like Metallophos PF00149.28 ELR12067.1 - 2.8e-22 80.2 2.7 4.5e-22 79.6 2.7 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_C PF14008.6 ELR12067.1 - 9.5e-19 68.0 1.4 2e-18 67.0 0.5 2.1 2 0 0 2 2 2 1 Iron/zinc purple acid phosphatase-like protein C Pur_ac_phosph_N PF16656.5 ELR12067.1 - 3.9e-17 62.6 0.6 7.3e-17 61.7 0.6 1.5 1 0 0 1 1 1 1 Purple acid Phosphatase, N-terminal domain Metallophos_2 PF12850.7 ELR12067.1 - 0.0024 18.1 0.0 0.0043 17.2 0.0 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Chromo PF00385.24 ELR12069.1 - 6.5e-14 51.6 3.3 2e-13 50.0 3.3 1.9 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain VWA PF00092.28 ELR12069.1 - 3e-06 27.6 0.0 6.2e-06 26.6 0.0 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain Tudor-knot PF11717.8 ELR12069.1 - 1.5 8.8 5.1 0.29 11.1 0.7 2.1 2 0 0 2 2 2 0 RNA binding activity-knot of a chromodomain VIT PF08487.10 ELR12070.1 - 4.5e-19 68.7 0.0 6.1e-19 68.3 0.0 1.2 1 0 0 1 1 1 1 Vault protein inter-alpha-trypsin domain VIT_2 PF13757.6 ELR12070.1 - 0.12 12.2 2.4 2.3 8.2 1.8 3.1 2 1 0 2 2 2 0 Vault protein inter-alpha-trypsin domain VWA_3 PF13768.6 ELR12071.1 - 6.2e-30 104.2 0.1 1.4e-29 103.0 0.1 1.6 2 0 0 2 2 2 1 von Willebrand factor type A domain VWA PF00092.28 ELR12071.1 - 1.3e-15 58.1 0.0 1.8e-15 57.6 0.0 1.2 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.6 ELR12071.1 - 1.6e-13 51.2 0.0 3.4e-13 50.2 0.0 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_CoxE PF05762.14 ELR12071.1 - 9.9e-06 25.1 0.2 1.7e-05 24.3 0.2 1.3 1 0 0 1 1 1 1 VWA domain containing CoxE-like protein DUF2201 PF09967.9 ELR12071.1 - 0.018 15.2 0.0 0.33 11.1 0.0 2.7 1 1 1 2 2 2 0 VWA-like domain (DUF2201) Shisa PF13908.6 ELR12072.1 - 0.00042 20.6 0.6 0.00053 20.3 0.6 1.2 1 0 0 1 1 1 1 Wnt and FGF inhibitory regulator TMEM154 PF15102.6 ELR12072.1 - 0.022 14.7 1.0 0.036 14.0 1.0 1.3 1 0 0 1 1 1 0 TMEM154 protein family Orf78 PF06024.12 ELR12072.1 - 0.53 10.6 2.1 0.95 9.8 2.1 1.4 1 0 0 1 1 1 0 Orf78 (ac78) DUF4834 PF16118.5 ELR12072.1 - 2.6 9.1 4.0 5.4 8.0 4.0 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) LRR_4 PF12799.7 ELR12073.1 - 1.9e-05 24.9 9.2 2.9 8.4 0.0 7.5 4 4 4 8 8 8 2 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 ELR12073.1 - 0.02 14.9 16.3 72 3.8 0.1 8.0 8 0 0 8 8 8 0 Leucine Rich repeat LRR_1 PF00560.33 ELR12073.1 - 0.31 11.8 15.6 1.5 9.7 0.3 7.5 9 0 0 9 9 9 0 Leucine Rich Repeat DUF4600 PF15372.6 ELR12074.1 - 0.099 13.1 8.3 0.15 12.5 8.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4600) TMCO5 PF14992.6 ELR12074.1 - 0.75 9.3 9.2 0.98 8.9 9.2 1.1 1 0 0 1 1 1 0 TMCO5 family Lzipper-MIP1 PF14389.6 ELR12074.1 - 1.6 9.1 11.4 2.2 8.6 3.3 2.2 2 0 0 2 2 2 0 Leucine-zipper of ternary complex factor MIP1 OmpH PF03938.14 ELR12074.1 - 3 8.2 13.3 4.2 7.7 13.3 1.1 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) HSP70 PF00012.20 ELR12074.1 - 3.6 5.7 7.6 4.2 5.4 7.6 1.0 1 0 0 1 1 1 0 Hsp70 protein APG6_N PF17675.1 ELR12074.1 - 4.5 7.8 14.8 6.3 7.3 14.8 1.2 1 0 0 1 1 1 0 Apg6 coiled-coil region PH PF00169.29 ELR12075.1 - 5.6e-17 62.2 0.0 1.1e-16 61.2 0.0 1.5 1 0 0 1 1 1 1 PH domain PH_11 PF15413.6 ELR12075.1 - 0.00076 19.9 0.0 0.23 11.9 0.0 2.7 3 0 0 3 3 2 1 Pleckstrin homology domain DUF4763 PF15960.5 ELR12075.1 - 0.0025 17.2 7.7 0.092 12.0 2.8 2.2 2 0 0 2 2 2 2 Domain of unknown function (DUF4763) DUF1796 PF08795.10 ELR12075.1 - 0.073 13.0 0.2 0.14 12.1 0.2 1.5 1 0 0 1 1 1 0 Putative papain-like cysteine peptidase (DUF1796) TEX13 PF15186.6 ELR12075.1 - 0.073 12.8 10.5 0.85 9.3 6.9 3.2 4 0 0 4 4 4 0 Testis-expressed sequence 13 protein family Lebercilin PF15619.6 ELR12075.1 - 0.11 12.1 21.4 0.24 11.1 0.2 2.4 2 0 0 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease IQCJ-SCHIP1 PF15157.6 ELR12075.1 - 0.17 11.8 12.8 0.2 11.5 1.1 2.3 1 1 1 2 2 2 0 Fusion protein IQCJ-SCHIP1 with IQ-like motif FAM76 PF16046.5 ELR12075.1 - 0.19 11.1 10.2 0.26 10.6 10.2 1.1 1 0 0 1 1 1 0 FAM76 protein ERM PF00769.19 ELR12075.1 - 0.28 11.0 19.2 0.49 10.2 19.2 1.3 1 0 0 1 1 1 0 Ezrin/radixin/moesin family DNA_topoisoIV PF00521.20 ELR12075.1 - 0.29 10.0 6.3 0.39 9.5 6.3 1.1 1 0 0 1 1 1 0 DNA gyrase/topoisomerase IV, subunit A PRP1_N PF06424.12 ELR12075.1 - 0.3 11.5 5.3 0.55 10.6 1.1 2.1 2 0 0 2 2 2 0 PRP1 splicing factor, N-terminal zf-C4H2 PF10146.9 ELR12075.1 - 0.54 10.5 14.6 0.039 14.3 8.9 1.8 2 0 0 2 2 2 0 Zinc finger-containing protein VPS38 PF17649.1 ELR12075.1 - 0.85 8.4 6.5 1.2 7.9 6.5 1.2 1 0 0 1 1 1 0 Vacuolar protein sorting 38 MCU PF04678.13 ELR12075.1 - 0.94 9.5 5.6 1.5 8.9 1.3 2.3 2 0 0 2 2 2 0 Mitochondrial calcium uniporter TMPIT PF07851.13 ELR12075.1 - 1.1 8.4 9.6 1.8 7.7 9.5 1.3 1 1 0 1 1 1 0 TMPIT-like protein Cep57_MT_bd PF06657.13 ELR12075.1 - 1.3 9.5 12.0 17 6.0 0.2 3.6 1 1 1 3 3 3 0 Centrosome microtubule-binding domain of Cep57 ALMT PF11744.8 ELR12075.1 - 1.7 7.4 4.4 2.3 7.0 4.4 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter WDCP PF15390.6 ELR12075.1 - 2.3 6.5 6.1 3.1 6.1 6.1 1.2 1 0 0 1 1 1 0 WD repeat and coiled-coil-containing protein family Csm1_N PF18504.1 ELR12075.1 - 2.8 8.3 18.5 5.5 7.4 0.4 3.3 3 0 0 3 3 3 0 Csm1 N-terminal domain DUF4200 PF13863.6 ELR12075.1 - 3.4 8.1 24.4 8.5 6.8 15.5 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4200) HIP1_clath_bdg PF16515.5 ELR12075.1 - 3.5 8.3 22.0 5.7 7.6 12.3 2.4 1 1 1 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Fib_alpha PF08702.10 ELR12075.1 - 4.3 7.5 10.9 3 8.0 6.6 2.1 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family JIP_LZII PF16471.5 ELR12075.1 - 4.5 7.5 13.2 12 6.1 7.4 2.5 2 0 0 2 2 2 0 JNK-interacting protein leucine zipper II PRKG1_interact PF15898.5 ELR12075.1 - 4.5 8.2 17.9 1.5 9.7 0.4 2.7 2 1 0 2 2 2 0 cGMP-dependent protein kinase interacting domain DASH_Spc34 PF08657.10 ELR12075.1 - 5.9 6.6 15.9 8.9 6.0 0.2 3.3 2 1 1 3 3 3 0 DASH complex subunit Spc34 BRE1 PF08647.11 ELR12075.1 - 6.1 7.0 18.3 2.9 8.0 11.1 2.4 2 0 0 2 2 2 0 BRE1 E3 ubiquitin ligase Prefoldin PF02996.17 ELR12075.1 - 8.3 6.3 12.7 36 4.3 0.1 2.8 2 1 1 3 3 3 0 Prefoldin subunit SlyX PF04102.12 ELR12075.1 - 8.7 7.1 12.8 2.2 8.9 1.0 3.0 3 0 0 3 3 2 0 SlyX CENP-H PF05837.12 ELR12075.1 - 9.9 6.6 15.6 38 4.7 15.5 1.9 1 1 0 1 1 1 0 Centromere protein H (CENP-H) PGP_phosphatase PF09419.10 ELR12077.1 - 3.2e-42 144.0 0.0 4.7e-42 143.5 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial PGP phosphatase Hydrolase_like PF13242.6 ELR12077.1 - 7.2e-05 22.8 0.0 0.00013 21.9 0.0 1.4 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase PF00702.26 ELR12077.1 - 0.054 13.8 0.0 1.7 8.9 0.0 2.2 1 1 0 2 2 2 0 haloacid dehalogenase-like hydrolase Complex1_LYR PF05347.15 ELR12078.1 - 1.2e-09 38.1 0.1 1.6e-09 37.6 0.1 1.2 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_2 PF13233.6 ELR12078.1 - 0.017 15.8 0.1 0.02 15.6 0.1 1.2 1 0 0 1 1 1 0 Complex1_LYR-like SF3A2 PF16835.5 ELR12079.1 - 3.8e-34 116.9 0.0 6e-34 116.3 0.0 1.3 1 0 0 1 1 1 1 Pre-mRNA-splicing factor SF3a complex subunit 2 (Prp11) CactinC_cactus PF09732.9 ELR12079.1 - 2.5e-05 24.2 0.2 3.9e-05 23.6 0.2 1.2 1 0 0 1 1 1 1 Cactus-binding C-terminus of cactin protein zf-met PF12874.7 ELR12079.1 - 0.0002 21.6 0.4 0.00051 20.3 0.4 1.7 1 0 0 1 1 1 1 Zinc-finger of C2H2 type DUF1534 PF07551.11 ELR12079.1 - 0.37 10.6 4.0 2 8.2 0.0 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF1534) Copine PF07002.16 ELR12081.1 - 7.1e-51 172.7 0.0 9.9e-51 172.3 0.0 1.2 1 0 0 1 1 1 1 Copine FYVE PF01363.21 ELR12081.1 - 0.0014 18.7 0.6 0.0031 17.6 0.6 1.5 1 0 0 1 1 1 1 FYVE zinc finger E7 PF00527.18 ELR12081.1 - 0.088 13.0 1.1 0.19 11.9 1.1 1.5 1 0 0 1 1 1 0 E7 protein, Early protein DUF2373 PF10180.9 ELR12083.1 - 1.1e-16 60.5 1.4 2.1e-16 59.5 1.4 1.6 1 0 0 1 1 1 1 Uncharacterised conserved protein (DUF2373) SAPS PF04499.15 ELR12083.1 - 0.38 9.5 10.2 0.54 9.0 10.2 1.3 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Ketoacyl-synt_2 PF13723.6 ELR12084.1 - 0.0023 17.6 1.3 0.0023 17.6 1.3 1.7 1 1 1 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain P_C PF06640.11 ELR12084.1 - 0.021 15.0 0.8 0.021 15.0 0.8 1.6 2 0 0 2 2 2 0 P protein C-terminus Doppel PF11466.8 ELR12084.1 - 0.39 10.4 2.3 0.92 9.2 2.3 1.5 1 0 0 1 1 1 0 Prion-like protein Doppel RNA_pol PF00940.19 ELR12085.1 - 2.6e-164 547.0 0.1 1.2e-163 544.8 0.0 2.1 2 1 0 2 2 2 1 DNA-dependent RNA polymerase RPOL_N PF14700.6 ELR12085.1 - 1.7e-62 211.7 4.6 1.7e-62 211.7 4.6 1.7 1 1 0 1 1 1 1 DNA-directed RNA polymerase N-terminal Hexapep PF00132.24 ELR12086.1 - 2e-09 36.8 13.0 0.0008 19.0 1.2 4.9 3 2 1 4 4 4 3 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 ELR12086.1 - 0.0015 18.2 4.6 1.2 8.9 1.3 4.1 3 1 0 3 3 3 2 Hexapeptide repeat of succinyl-transferase Pro-kuma_activ PF09286.11 ELR12087.1 - 1.4e-26 93.5 0.0 6.4e-25 88.1 0.0 2.2 2 0 0 2 2 2 1 Pro-kumamolisin, activation domain Peptidase_S8 PF00082.22 ELR12087.1 - 0.0076 15.5 0.7 0.013 14.7 0.7 1.3 1 0 0 1 1 1 1 Subtilase family Methyltransf_11 PF08241.12 ELR12088.1 - 1.7e-14 54.3 0.1 3.2e-14 53.3 0.1 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ELR12088.1 - 3.1e-11 43.8 0.0 9.2e-11 42.3 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 ELR12088.1 - 3.3e-11 43.2 0.0 4.8e-11 42.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 ELR12088.1 - 0.014 14.7 0.0 0.021 14.1 0.0 1.2 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family PH PF00169.29 ELR12089.1 - 3e-60 201.2 3.2 5.8e-21 75.0 0.1 5.2 4 1 0 4 4 4 4 PH domain ArfGap PF01412.18 ELR12089.1 - 2.8e-39 133.8 0.1 1e-38 132.0 0.1 2.0 2 0 0 2 2 2 1 Putative GTPase activating protein for Arf PH_8 PF15409.6 ELR12089.1 - 1.6e-14 54.0 0.5 6.1e-09 36.1 0.2 4.6 4 0 0 4 4 4 1 Pleckstrin homology domain PH_11 PF15413.6 ELR12089.1 - 2.8e-09 37.3 23.5 3.1e-06 27.5 1.6 7.2 4 4 1 5 5 5 2 Pleckstrin homology domain PH_3 PF14593.6 ELR12089.1 - 5.9e-09 36.0 0.7 2.6e-05 24.3 0.1 4.0 4 0 0 4 4 4 1 PH domain PH_17 PF18012.1 ELR12089.1 - 3.8e-05 23.3 0.6 0.17 11.7 0.0 3.7 3 0 0 3 3 3 2 PH domain PH_9 PF15410.6 ELR12089.1 - 4.9e-05 23.7 9.5 3.8 7.9 0.3 6.5 4 3 2 6 6 6 2 Pleckstrin homology domain PH_13 PF16652.5 ELR12089.1 - 5.5e-05 23.0 0.2 2.1 8.2 0.1 4.1 4 0 0 4 4 4 2 Pleckstrin homology domain Mcp5_PH PF12814.7 ELR12089.1 - 0.0065 16.6 0.1 3.1 7.9 0.0 3.8 4 0 0 4 4 4 1 Meiotic cell cortex C-terminal pleckstrin homology PH_12 PF16457.5 ELR12089.1 - 0.019 15.5 0.4 5.9 7.4 0.0 3.4 4 0 0 4 4 4 0 Pleckstrin homology domain PH_15 PF17339.2 ELR12089.1 - 0.053 13.4 1.5 3.5 7.6 0.1 3.7 4 0 0 4 4 4 0 PH domain PH_6 PF15406.6 ELR12089.1 - 0.11 12.7 1.1 0.75 10.1 0.1 2.9 4 0 0 4 4 4 0 Pleckstrin homology domain tRNA-synt_1 PF00133.22 ELR12090.1 - 3.4e-44 151.1 0.0 1.8e-30 105.8 0.0 2.5 2 1 0 2 2 2 2 tRNA synthetases class I (I, L, M and V) tRNA-synt_1g PF09334.11 ELR12090.1 - 2e-21 76.2 0.0 9.9e-12 44.3 0.0 2.9 3 0 0 3 3 3 2 tRNA synthetases class I (M) Anticodon_1 PF08264.13 ELR12090.1 - 1e-09 38.5 0.0 2.2e-09 37.5 0.0 1.6 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1e PF01406.19 ELR12090.1 - 3.4e-08 33.2 0.0 6.5e-08 32.3 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain tRNA-synt_1f PF01921.18 ELR12090.1 - 0.0083 15.1 0.0 0.016 14.1 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetases class I (K) Ank_2 PF12796.7 ELR12091.1 - 2.5e-28 98.5 2.6 5e-11 43.0 0.0 3.9 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ELR12091.1 - 6.4e-24 84.0 1.7 1.5e-07 31.8 0.2 4.5 2 1 2 4 4 4 4 Ankyrin repeats (many copies) Ank_5 PF13857.6 ELR12091.1 - 6e-20 71.1 0.1 1.2e-06 28.7 0.1 4.5 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 ELR12091.1 - 2.4e-19 67.4 0.1 0.0015 18.8 0.2 7.0 8 0 0 8 8 6 4 Ankyrin repeat DUF2199 PF09965.9 ELR12091.1 - 5.4e-19 68.7 0.0 1e-18 67.8 0.0 1.4 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2199) Ank PF00023.30 ELR12091.1 - 5.8e-18 64.5 1.1 0.00021 21.6 0.2 5.7 7 0 0 7 7 6 3 Ankyrin repeat Nop14 PF04147.12 ELR12091.1 - 0.03 12.6 10.6 0.06 11.6 10.6 1.4 1 0 0 1 1 1 0 Nop14-like family NOA36 PF06524.12 ELR12091.1 - 0.05 12.9 9.4 0.14 11.4 9.4 1.7 1 0 0 1 1 1 0 NOA36 protein CDC45 PF02724.14 ELR12091.1 - 0.27 9.5 7.5 0.4 8.9 7.5 1.3 1 0 0 1 1 1 0 CDC45-like protein LRS4 PF10422.9 ELR12091.1 - 0.33 10.5 4.6 0.65 9.5 4.6 1.4 1 0 0 1 1 1 0 Monopolin complex subunit LRS4 YL1 PF05764.13 ELR12091.1 - 0.49 10.5 14.4 0.062 13.4 9.7 1.8 2 0 0 2 2 2 0 YL1 nuclear protein eIF-3c_N PF05470.12 ELR12091.1 - 0.5 8.6 3.5 0.73 8.1 3.5 1.3 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 8 N-terminus RXT2_N PF08595.11 ELR12091.1 - 1.2 9.1 4.4 4.9 7.2 4.4 2.0 1 0 0 1 1 1 0 RXT2-like, N-terminal RRN3 PF05327.11 ELR12091.1 - 2.2 6.7 5.2 23 3.4 7.0 1.7 2 0 0 2 2 2 0 RNA polymerase I specific transcription initiation factor RRN3 NAD_binding_2 PF03446.15 ELR12092.1 - 5.6e-49 166.3 1.5 7.9e-49 165.8 1.5 1.2 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.6 ELR12092.1 - 7.8e-35 119.8 0.1 1.6e-34 118.8 0.1 1.5 1 0 0 1 1 1 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase F420_oxidored PF03807.17 ELR12092.1 - 3.6e-07 30.7 0.0 7e-07 29.7 0.0 1.6 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent Shikimate_DH PF01488.20 ELR12092.1 - 7.3e-05 22.9 0.0 0.00013 22.0 0.0 1.4 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase 2-Hacid_dh_C PF02826.19 ELR12092.1 - 8.3e-05 22.0 0.0 0.00014 21.2 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 3HCDH_N PF02737.18 ELR12092.1 - 0.00041 20.3 0.0 0.00085 19.3 0.0 1.5 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain ApbA PF02558.16 ELR12092.1 - 0.00091 18.9 0.1 0.0016 18.1 0.1 1.4 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA NAD_binding_7 PF13241.6 ELR12092.1 - 0.012 16.0 0.0 0.027 14.9 0.0 1.6 1 0 0 1 1 1 0 Putative NAD(P)-binding UCH PF00443.29 ELR12093.1 - 1.7e-13 50.6 0.0 8.1e-13 48.4 0.0 2.0 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 ELR12093.1 - 6e-05 22.8 0.4 0.00013 21.7 0.4 1.5 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase WD40 PF00400.32 ELR12094.1 - 6.5e-09 36.3 18.8 0.68 10.9 0.1 7.4 7 1 0 7 7 7 5 WD domain, G-beta repeat WD40 PF00400.32 ELR12095.1 - 4.2e-44 147.7 28.8 1.2e-07 32.3 0.4 11.9 12 0 0 12 12 12 9 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ELR12095.1 - 1e-21 77.0 1.3 0.00043 20.5 0.1 6.9 4 3 3 7 7 7 6 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 ELR12095.1 - 4.9e-08 33.1 0.0 0.0037 17.2 0.0 3.6 2 1 1 3 3 3 3 Eukaryotic translation initiation factor eIF2A PD40 PF07676.12 ELR12095.1 - 1.2e-07 31.5 4.9 1.6 8.8 0.0 6.9 7 0 0 7 7 7 2 WD40-like Beta Propeller Repeat Ge1_WD40 PF16529.5 ELR12095.1 - 0.00097 18.2 0.1 2.1 7.2 0.1 4.2 3 1 2 5 5 5 1 WD40 region of Ge1, enhancer of mRNA-decapping protein SAD_SRA PF02182.17 ELR12095.1 - 0.0075 16.0 0.0 0.019 14.7 0.0 1.7 1 0 0 1 1 1 1 SAD/SRA domain WD40_like PF17005.5 ELR12095.1 - 0.069 12.5 0.0 0.84 8.9 0.0 2.4 2 0 0 2 2 2 0 WD40-like domain IKI3 PF04762.12 ELR12095.1 - 0.11 10.5 0.1 2.8 5.8 0.0 2.3 2 0 0 2 2 2 0 IKI3 family PQQ_3 PF13570.6 ELR12095.1 - 0.2 12.2 3.7 8.4 7.0 0.1 4.8 4 1 1 5 5 5 0 PQQ-like domain DUF2514 PF10721.9 ELR12095.1 - 0.59 10.1 10.9 1.1 9.2 10.9 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2514) T2SSM PF04612.12 ELR12095.1 - 2.6 8.1 8.6 4.9 7.2 8.6 1.4 1 0 0 1 1 1 0 Type II secretion system (T2SS), protein M WD40 PF00400.32 ELR12097.1 - 7.9e-11 42.3 5.9 0.00012 22.8 0.6 3.1 3 0 0 3 3 3 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ELR12097.1 - 2e-06 28.0 0.1 9.8e-06 25.8 0.2 1.9 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 4 WD40 domain DUF563 PF04577.14 ELR12100.1 - 2.3e-21 76.9 0.1 3.4e-21 76.4 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF563) TMF_DNA_bd PF12329.8 ELR12101.1 - 2.4e-12 46.6 16.9 2.4e-12 46.6 16.9 6.7 4 2 2 6 6 6 1 TATA element modulatory factor 1 DNA binding FANCI_HD2 PF14680.6 ELR12101.1 - 2.9 7.1 9.1 0.058 12.6 1.1 2.1 2 0 0 2 2 2 0 FANCI helical domain 2 APG6_N PF17675.1 ELR12102.1 - 0.027 15.0 5.3 0.027 15.0 5.3 2.5 2 1 0 2 2 2 0 Apg6 coiled-coil region SPT16 PF08644.11 ELR12102.1 - 0.045 13.9 0.7 0.045 13.9 0.7 2.2 2 0 0 2 2 2 0 FACT complex subunit (SPT16/CDC68) Cob_adeno_trans PF01923.18 ELR12102.1 - 0.074 13.2 1.8 0.2 11.8 1.8 1.6 1 0 0 1 1 1 0 Cobalamin adenosyltransferase SlyX PF04102.12 ELR12102.1 - 0.85 10.3 4.3 2.8 8.6 4.3 1.9 1 0 0 1 1 1 0 SlyX Spc7 PF08317.11 ELR12102.1 - 6.9 5.4 14.7 0.018 14.0 3.6 2.0 3 0 0 3 3 3 0 Spc7 kinetochore protein YabA PF06156.13 ELR12102.1 - 8.6 7.1 9.2 0.15 12.7 1.2 2.2 3 0 0 3 3 3 0 Initiation control protein YabA RhoGEF PF00621.20 ELR12103.1 - 8.2e-37 127.2 2.5 8.2e-37 127.2 2.5 2.0 2 1 0 2 2 2 1 RhoGEF domain PX PF00787.24 ELR12103.1 - 1.1e-16 60.8 2.1 1.5e-16 60.3 0.6 2.1 2 0 0 2 2 2 1 PX domain SH3_9 PF14604.6 ELR12103.1 - 3.9e-13 49.0 0.6 8.2e-13 48.0 0.6 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 ELR12103.1 - 1.3e-12 47.2 0.5 2.6e-12 46.1 0.5 1.6 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 ELR12103.1 - 3.8e-10 39.3 0.3 7.9e-10 38.3 0.3 1.6 1 0 0 1 1 1 1 Variant SH3 domain C1_1 PF00130.22 ELR12103.1 - 0.35 10.8 4.4 6.4 6.7 4.4 2.3 1 1 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) CBS PF00571.28 ELR12105.1 - 1e-30 106.0 5.9 4.6e-09 36.6 0.1 4.2 4 0 0 4 4 4 4 CBS domain Globin PF00042.22 ELR12105.1 - 0.1 13.1 0.1 14 6.3 0.1 2.6 2 0 0 2 2 2 0 Globin RNA_lig_T4_1 PF09511.10 ELR12106.1 - 7.6e-20 71.7 0.0 1.4e-18 67.6 0.0 2.2 1 1 0 1 1 1 1 RNA ligase PGA2 PF07543.12 ELR12106.1 - 0.75 9.8 4.1 1.3 9.0 4.1 1.3 1 0 0 1 1 1 0 Protein trafficking PGA2 DHDPS PF00701.22 ELR12107.1 - 6.9e-58 195.6 0.0 8.2e-58 195.4 0.0 1.1 1 0 0 1 1 1 1 Dihydrodipicolinate synthetase family Clathrin-link PF09268.10 ELR12107.1 - 0.78 9.2 0.0 0.78 9.2 0.0 2.3 2 0 0 2 2 2 0 Clathrin, heavy-chain linker UQ_con PF00179.26 ELR12108.1 - 2.1e-06 27.4 0.0 3.8e-06 26.6 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme SDA1 PF05285.12 ELR12109.1 - 0.058 12.8 43.2 0.072 12.5 43.2 1.1 1 0 0 1 1 1 0 SDA1 CDC27 PF09507.10 ELR12109.1 - 0.46 9.8 33.1 0.59 9.5 33.1 1.0 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Nop14 PF04147.12 ELR12109.1 - 1.1 7.4 46.1 1.4 7.1 46.1 1.1 1 0 0 1 1 1 0 Nop14-like family BUD22 PF09073.10 ELR12109.1 - 2.1 7.6 37.6 2.6 7.3 37.6 1.1 1 0 0 1 1 1 0 BUD22 TFIIF_alpha PF05793.12 ELR12109.1 - 2.6 6.5 36.9 2.9 6.4 36.9 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) ApoL PF05461.11 ELR12109.1 - 3 7.1 8.9 5.1 6.3 8.9 1.3 1 0 0 1 1 1 0 Apolipoprotein L R2K_2 PF18299.1 ELR12110.1 - 0.024 14.5 0.0 0.028 14.3 0.0 1.1 1 0 0 1 1 1 0 ATP-grasp domain, R2K clade family 2 ATP-grasp_2 PF08442.10 ELR12111.1 - 3.8e-54 183.3 0.0 4.6e-54 183.1 0.0 1.0 1 0 0 1 1 1 1 ATP-grasp domain ATP-grasp_5 PF13549.6 ELR12111.1 - 7e-08 32.2 0.1 9.9e-08 31.7 0.1 1.2 1 0 0 1 1 1 1 ATP-grasp domain GARS_A PF01071.19 ELR12111.1 - 1.4e-05 25.0 0.1 3.4e-05 23.7 0.1 1.6 1 1 0 1 1 1 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain WSN PF02206.18 ELR12112.1 - 0.038 13.9 0.1 0.079 12.9 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function Pkinase PF00069.25 ELR12113.1 - 2.7e-68 230.2 0.0 4.3e-68 229.6 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR12113.1 - 3e-37 128.3 0.0 5e-37 127.6 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ELR12113.1 - 1.3e-06 28.0 0.0 2.2e-06 27.2 0.0 1.4 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 ELR12113.1 - 0.00046 20.2 2.7 0.062 13.2 0.8 2.4 1 1 1 2 2 2 2 Phosphotransferase enzyme family Haspin_kinase PF12330.8 ELR12113.1 - 0.0016 17.4 1.2 0.0019 17.2 0.0 1.7 2 0 0 2 2 2 1 Haspin like kinase domain Kdo PF06293.14 ELR12113.1 - 0.0063 15.9 0.0 0.012 15.0 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family MIS13 PF08202.11 ELR12114.1 - 0.0018 17.6 1.2 0.0021 17.4 1.2 1.0 1 0 0 1 1 1 1 Mis12-Mtw1 protein family TPR_MLP1_2 PF07926.12 ELR12114.1 - 0.0025 17.9 0.7 0.0025 17.9 0.7 1.5 1 1 0 1 1 1 1 TPR/MLP1/MLP2-like protein Dor1 PF04124.12 ELR12114.1 - 0.0041 15.9 1.4 0.0048 15.6 1.4 1.0 1 0 0 1 1 1 1 Dor1-like family Apolipoprotein PF01442.18 ELR12114.1 - 0.0046 16.9 4.9 0.007 16.3 4.9 1.3 1 0 0 1 1 1 1 Apolipoprotein A1/A4/E domain YgaB PF14182.6 ELR12114.1 - 0.005 17.2 0.7 0.011 16.1 0.5 1.6 1 1 1 2 2 2 1 YgaB-like protein Seryl_tRNA_N PF02403.22 ELR12114.1 - 0.01 16.0 2.7 0.016 15.4 1.8 1.8 1 1 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain SlyX PF04102.12 ELR12114.1 - 0.017 15.7 1.5 1.2 9.8 0.2 2.2 1 1 1 2 2 2 0 SlyX APG17 PF04108.12 ELR12114.1 - 0.023 13.9 2.8 0.025 13.7 2.8 1.0 1 0 0 1 1 1 0 Autophagy protein Apg17 TMF_TATA_bd PF12325.8 ELR12114.1 - 0.023 14.9 3.3 0.076 13.2 3.3 1.8 1 1 0 1 1 1 0 TATA element modulatory factor 1 TATA binding Phage_GP20 PF06810.11 ELR12114.1 - 0.023 14.5 4.3 0.034 14.0 4.3 1.3 1 0 0 1 1 1 0 Phage minor structural protein GP20 BLOC1_2 PF10046.9 ELR12114.1 - 0.03 14.6 1.6 0.053 13.8 1.1 1.6 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Fzo_mitofusin PF04799.13 ELR12114.1 - 0.037 13.6 0.5 0.052 13.1 0.5 1.3 1 0 0 1 1 1 0 fzo-like conserved region Npun_R1517 PF18068.1 ELR12114.1 - 0.043 14.1 0.8 0.073 13.4 0.5 1.6 1 1 1 2 2 2 0 Npun R1517 RasGAP_C PF03836.15 ELR12114.1 - 0.056 13.6 0.1 0.062 13.4 0.1 1.2 1 0 0 1 1 1 0 RasGAP C-terminus CENP-H PF05837.12 ELR12114.1 - 0.071 13.5 3.7 1.7 9.1 0.3 2.1 1 1 1 2 2 2 0 Centromere protein H (CENP-H) SseB_C PF14581.6 ELR12114.1 - 0.085 13.0 0.1 0.13 12.4 0.1 1.2 1 0 0 1 1 1 0 SseB protein C-terminal domain TSC22 PF01166.18 ELR12114.1 - 0.11 12.8 1.4 2 8.8 0.5 2.2 1 1 1 2 2 2 0 TSC-22/dip/bun family Spc7 PF08317.11 ELR12114.1 - 0.11 11.3 3.6 0.14 11.0 3.6 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein Bacillus_HBL PF05791.11 ELR12114.1 - 0.13 12.1 1.1 0.16 11.8 1.1 1.2 1 0 0 1 1 1 0 Bacillus haemolytic enterotoxin (HBL) DUF1664 PF07889.12 ELR12114.1 - 0.16 12.0 1.7 0.23 11.5 1.7 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) COG2 PF06148.11 ELR12114.1 - 0.16 12.1 2.9 1.6 8.8 2.9 1.9 1 1 0 1 1 1 0 COG (conserved oligomeric Golgi) complex component, COG2 LPP PF04728.13 ELR12114.1 - 0.17 12.3 2.9 3.2 8.2 1.5 2.5 1 1 1 2 2 2 0 Lipoprotein leucine-zipper PEP-utilisers_N PF05524.13 ELR12114.1 - 0.19 11.9 5.7 0.32 11.2 5.7 1.5 1 1 0 1 1 1 0 PEP-utilising enzyme, N-terminal ApoO PF09769.9 ELR12114.1 - 0.21 11.5 0.1 0.3 11.1 0.1 1.2 1 0 0 1 1 1 0 Apolipoprotein O DUF2508 PF10704.9 ELR12114.1 - 0.31 11.2 3.7 0.16 12.1 0.9 2.1 2 1 1 3 3 2 0 Protein of unknown function (DUF2508) Cnn_1N PF07989.11 ELR12114.1 - 0.36 11.0 3.7 0.54 10.5 1.1 2.2 1 1 1 2 2 2 0 Centrosomin N-terminal motif 1 Rotamase PF00639.21 ELR12114.1 - 0.46 11.5 3.2 1 10.4 0.5 2.0 1 1 1 2 2 2 0 PPIC-type PPIASE domain YtxH PF12732.7 ELR12114.1 - 2.7 8.6 5.5 13 6.4 5.4 2.1 1 1 0 1 1 1 0 YtxH-like protein Pkinase PF00069.25 ELR12115.1 - 4.9e-63 213.0 0.0 1e-62 211.9 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR12115.1 - 3.3e-32 111.8 0.0 9.3e-32 110.3 0.0 1.7 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ELR12115.1 - 2.8e-11 43.3 0.0 6e-11 42.2 0.0 1.5 2 0 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 ELR12115.1 - 0.00016 20.6 0.0 0.0003 19.7 0.0 1.6 1 1 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 ELR12115.1 - 0.0012 18.2 0.0 0.0021 17.4 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 ELR12115.1 - 0.0057 16.6 2.1 0.02 14.8 0.1 2.6 2 1 1 3 3 3 1 Phosphotransferase enzyme family RIO1 PF01163.22 ELR12115.1 - 0.0065 16.1 0.0 0.012 15.2 0.0 1.4 1 0 0 1 1 1 1 RIO1 family Cyt-b5 PF00173.28 ELR12116.1 - 1.7e-22 79.3 0.2 1.9e-22 79.2 0.2 1.0 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain ABC_tran PF00005.27 ELR12117.1 - 1.5e-25 90.3 0.0 2e-25 89.9 0.0 1.2 1 0 0 1 1 1 1 ABC transporter AAA_16 PF13191.6 ELR12117.1 - 0.00016 22.1 0.1 0.0012 19.3 0.1 2.0 1 1 0 2 2 2 1 AAA ATPase domain RsgA_GTPase PF03193.16 ELR12117.1 - 0.0012 18.8 0.0 0.002 18.0 0.0 1.3 1 0 0 1 1 1 1 RsgA GTPase AAA_22 PF13401.6 ELR12117.1 - 0.003 17.8 0.0 0.0057 16.9 0.0 1.7 1 1 0 1 1 1 1 AAA domain AAA PF00004.29 ELR12117.1 - 0.0031 17.9 0.0 0.0071 16.8 0.0 1.6 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) NACHT PF05729.12 ELR12117.1 - 0.006 16.5 0.0 0.014 15.3 0.0 1.6 1 0 0 1 1 1 1 NACHT domain Viral_helicase1 PF01443.18 ELR12117.1 - 0.0084 15.9 0.0 0.012 15.4 0.0 1.3 1 0 0 1 1 1 1 Viral (Superfamily 1) RNA helicase AAA_5 PF07728.14 ELR12117.1 - 0.009 16.0 0.2 0.018 15.1 0.2 1.5 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_28 PF13521.6 ELR12117.1 - 0.0096 16.2 0.0 0.025 14.8 0.0 1.7 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.6 ELR12117.1 - 0.01 16.4 0.0 0.018 15.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain Zeta_toxin PF06414.12 ELR12117.1 - 0.01 15.1 0.0 0.039 13.2 0.0 1.8 2 0 0 2 2 2 0 Zeta toxin Rad17 PF03215.15 ELR12117.1 - 0.016 15.1 0.0 0.023 14.7 0.0 1.3 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_25 PF13481.6 ELR12117.1 - 0.016 14.8 0.0 0.025 14.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain DUF815 PF05673.13 ELR12117.1 - 0.019 14.1 0.0 0.031 13.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_29 PF13555.6 ELR12117.1 - 0.021 14.5 0.0 0.046 13.5 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_21 PF13304.6 ELR12117.1 - 0.031 14.1 0.0 1.1 9.1 0.0 2.3 2 0 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system MMR_HSR1 PF01926.23 ELR12117.1 - 0.053 13.6 0.0 0.11 12.6 0.0 1.6 1 0 0 1 1 1 0 50S ribosome-binding GTPase RNA_helicase PF00910.22 ELR12117.1 - 0.065 13.6 0.0 0.12 12.8 0.0 1.4 1 0 0 1 1 1 0 RNA helicase Filamin PF00630.19 ELR12118.1 - 1.4e-18 67.6 0.0 1.6e-09 38.5 0.0 2.2 2 0 0 2 2 2 2 Filamin/ABP280 repeat Invasin_D3 PF09134.10 ELR12118.1 - 7.5e-05 23.0 0.0 0.02 15.2 0.0 2.4 2 0 0 2 2 2 2 Invasin, domain 3 Big_1 PF02369.16 ELR12118.1 - 0.0032 17.5 0.0 0.0097 15.9 0.0 1.8 1 0 0 1 1 1 1 Bacterial Ig-like domain (group 1) Big_3_5 PF16640.5 ELR12118.1 - 0.015 15.5 0.1 0.035 14.3 0.1 1.6 1 0 0 1 1 1 0 Bacterial Ig-like domain (group 3) OTU PF02338.19 ELR12119.1 - 4.9e-16 59.4 0.0 8.6e-16 58.6 0.0 1.4 1 0 0 1 1 1 1 OTU-like cysteine protease Peptidase_C65 PF10275.9 ELR12119.1 - 0.015 14.8 0.0 0.44 9.9 0.0 2.2 2 0 0 2 2 2 0 Peptidase C65 Otubain UIM PF02809.20 ELR12119.1 - 0.11 12.5 3.9 0.49 10.4 3.9 2.2 1 0 0 1 1 1 0 Ubiquitin interaction motif DDE_Tnp_1_3 PF13612.6 ELR12119.1 - 0.2 11.7 0.0 0.45 10.5 0.0 1.5 1 1 1 2 2 2 0 Transposase DDE domain UDPG_MGDP_dh_N PF03721.14 ELR12120.1 - 7.5e-54 182.2 0.1 1.1e-53 181.6 0.1 1.2 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain UDPG_MGDP_dh PF00984.19 ELR12120.1 - 1.9e-24 85.7 0.0 4.2e-24 84.6 0.0 1.6 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, central domain Sacchrp_dh_NADP PF03435.18 ELR12120.1 - 0.00089 19.5 0.1 0.003 17.8 0.0 2.0 2 2 0 2 2 2 1 Saccharopine dehydrogenase NADP binding domain GFO_IDH_MocA PF01408.22 ELR12120.1 - 0.0086 16.9 0.0 0.032 15.1 0.0 2.0 1 1 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold NAD_binding_7 PF13241.6 ELR12120.1 - 0.054 13.9 0.0 0.41 11.1 0.0 2.5 1 1 1 2 2 2 0 Putative NAD(P)-binding 3HCDH_N PF02737.18 ELR12120.1 - 0.062 13.2 0.0 0.17 11.8 0.0 1.8 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain TrkA_N PF02254.18 ELR12120.1 - 0.072 13.3 0.0 2.7 8.3 0.0 2.6 2 0 0 2 2 2 0 TrkA-N domain Shikimate_DH PF01488.20 ELR12120.1 - 0.093 12.8 0.1 6.1 6.9 0.0 2.7 3 0 0 3 3 3 0 Shikimate / quinate 5-dehydrogenase Paf67 PF10255.9 ELR12121.1 - 3.6e-113 378.6 0.1 4.5e-59 200.5 0.0 2.4 2 1 1 3 3 3 2 RNA polymerase I-associated factor PAF67 DUF5600 PF18150.1 ELR12122.1 - 1.3e-42 144.7 0.3 2.3e-42 143.9 0.3 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF5600) EF-hand_4 PF12763.7 ELR12122.1 - 4.8e-17 61.8 0.0 1.5e-16 60.2 0.0 1.8 2 0 0 2 2 2 1 Cytoskeletal-regulatory complex EF hand Dynamin_N PF00350.23 ELR12122.1 - 1.8e-14 54.1 0.0 3.9e-13 49.8 0.0 2.2 1 1 0 1 1 1 1 Dynamin family MMR_HSR1 PF01926.23 ELR12122.1 - 1e-07 32.0 0.0 1.9e-07 31.2 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase EHD_N PF16880.5 ELR12122.1 - 8.1e-05 22.4 2.9 8.1e-05 22.4 2.9 1.7 2 0 0 2 2 1 1 N-terminal EH-domain containing protein EF-hand_8 PF13833.6 ELR12122.1 - 0.00011 21.9 2.0 0.17 11.7 0.1 3.2 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_1 PF00036.32 ELR12122.1 - 0.00014 21.2 0.1 0.00052 19.4 0.0 2.2 2 0 0 2 2 2 1 EF hand EF-hand_6 PF13405.6 ELR12122.1 - 0.00094 18.9 0.0 0.0052 16.6 0.0 2.3 1 0 0 1 1 1 1 EF-hand domain Roc PF08477.13 ELR12122.1 - 0.0019 18.4 0.0 1.6 9.0 0.0 2.3 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase EF-hand_7 PF13499.6 ELR12122.1 - 0.018 15.5 0.0 0.14 12.6 0.0 2.4 2 0 0 2 2 2 0 EF-hand domain pair GTP_EFTU PF00009.27 ELR12122.1 - 0.051 13.1 0.0 0.13 11.8 0.0 1.7 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 ELR12122.1 - 0.069 12.5 0.0 3.8 6.8 0.0 2.2 2 0 0 2 2 2 0 Gtr1/RagA G protein conserved region EF-hand_5 PF13202.6 ELR12122.1 - 0.085 12.4 0.5 0.31 10.6 0.5 2.0 1 0 0 1 1 1 0 EF hand CsbD PF05532.12 ELR12123.1 - 0.0032 17.3 2.7 0.0034 17.2 1.3 1.7 2 0 0 2 2 2 1 CsbD-like NicO PF03824.16 ELR12123.1 - 0.26 10.6 7.0 0.42 9.9 7.0 1.3 1 0 0 1 1 1 0 High-affinity nickel-transport protein rve PF00665.26 ELR12126.1 - 0.047 13.9 0.0 0.073 13.3 0.0 1.3 1 0 0 1 1 1 0 Integrase core domain DUF2703 PF10865.8 ELR12126.1 - 0.87 9.8 3.3 1.4 9.1 1.1 2.0 1 1 0 2 2 2 0 Domain of unknown function (DUF2703) CsbD PF05532.12 ELR12127.1 - 0.00057 19.7 0.9 0.00091 19.1 0.9 1.2 1 0 0 1 1 1 1 CsbD-like Cuticle_3 PF11018.8 ELR12127.1 - 0.047 13.9 1.1 0.062 13.5 1.1 1.2 1 0 0 1 1 1 0 Pupal cuticle protein C1 CsbD PF05532.12 ELR12130.1 - 0.002 18.0 0.4 0.0034 17.3 0.4 1.3 1 0 0 1 1 1 1 CsbD-like Cuticle_3 PF11018.8 ELR12130.1 - 0.59 10.3 8.7 1.2 9.4 8.7 1.4 1 0 0 1 1 1 0 Pupal cuticle protein C1 Gram_pos_anchor PF00746.21 ELR12131.1 - 0.15 12.1 3.1 0.25 11.3 3.1 1.5 1 0 0 1 1 1 0 LPXTG cell wall anchor motif ClpB_D2-small PF10431.9 ELR12132.1 - 6.4e-24 83.8 0.6 1.3e-23 82.9 0.6 1.5 1 0 0 1 1 1 1 C-terminal, D2-small domain, of ClpB protein AAA_2 PF07724.14 ELR12132.1 - 3.2e-22 79.5 0.2 3.2e-22 79.5 0.2 1.8 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_5 PF07728.14 ELR12132.1 - 0.0072 16.3 0.0 0.013 15.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AP3D1 PF06375.11 ELR12132.1 - 0.036 14.3 11.7 0.059 13.6 11.7 1.4 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 NPR3 PF03666.13 ELR12132.1 - 0.052 12.3 6.3 0.071 11.9 6.3 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 FAM220 PF15487.6 ELR12132.1 - 0.11 12.1 6.8 0.16 11.5 6.8 1.2 1 0 0 1 1 1 0 FAM220 family Zip PF02535.22 ELR12132.1 - 0.27 10.4 4.2 0.33 10.1 4.2 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter TMEM237 PF15383.6 ELR12132.1 - 0.73 8.9 3.0 1.1 8.3 3.0 1.2 1 0 0 1 1 1 0 Transmembrane protein 237 RRN3 PF05327.11 ELR12132.1 - 1 7.8 5.2 1.4 7.3 5.2 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 TFIIF_alpha PF05793.12 ELR12132.1 - 2.3 6.7 22.8 3.1 6.3 22.8 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) DNA_pol_phi PF04931.13 ELR12132.1 - 6.4 4.7 12.9 8.9 4.3 12.9 1.2 1 0 0 1 1 1 0 DNA polymerase phi HA2 PF04408.23 ELR12133.1 - 1.1e-21 77.1 0.0 1.1e-21 77.1 0.0 4.1 3 1 0 3 3 2 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 ELR12133.1 - 8.8e-21 74.1 0.1 2.1e-20 72.9 0.1 1.6 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 ELR12133.1 - 1e-13 51.6 0.0 3.2e-13 50.0 0.0 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain AAA_22 PF13401.6 ELR12133.1 - 5.4e-06 26.7 0.6 6.5e-05 23.2 0.0 2.7 2 0 0 2 2 2 1 AAA domain DEAD PF00270.29 ELR12133.1 - 4.5e-05 23.3 2.4 9.9e-05 22.2 0.0 2.7 3 0 0 3 3 3 1 DEAD/DEAH box helicase T2SSE PF00437.20 ELR12133.1 - 0.0033 16.5 0.0 0.0075 15.4 0.0 1.5 1 0 0 1 1 1 1 Type II/IV secretion system protein PWI PF01480.17 ELR12133.1 - 0.0034 17.7 0.0 0.013 15.8 0.0 2.1 1 0 0 1 1 1 1 PWI domain PhoH PF02562.16 ELR12133.1 - 0.0086 15.5 0.1 0.78 9.2 0.0 2.6 2 1 0 2 2 2 1 PhoH-like protein AAA_19 PF13245.6 ELR12133.1 - 0.011 16.1 0.1 0.047 14.0 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.6 ELR12133.1 - 0.068 13.6 2.5 0.18 12.2 0.0 2.8 2 1 0 2 2 2 0 AAA ATPase domain ResIII PF04851.15 ELR12133.1 - 0.081 12.9 9.3 3.7 7.5 1.5 4.1 4 0 0 4 4 4 0 Type III restriction enzyme, res subunit AAA_23 PF13476.6 ELR12133.1 - 0.67 10.4 0.0 0.67 10.4 0.0 4.3 3 1 0 3 3 2 0 AAA domain ABC_tran PF00005.27 ELR12133.1 - 0.85 10.1 0.0 0.85 10.1 0.0 3.3 4 1 0 4 4 3 0 ABC transporter LAMTOR PF15454.6 ELR12134.1 - 0.00015 22.3 0.6 0.00033 21.2 0.4 1.8 1 1 0 1 1 1 1 Late endosomal/lysosomal adaptor and MAPK and MTOR activator NSP2-B_epitope PF14757.6 ELR12134.1 - 0.047 13.4 3.1 0.17 11.6 3.1 1.7 1 1 0 1 1 1 0 Immunogenic region of nsp2 protein of arterivirus polyprotein Peptidase_C54 PF03416.19 ELR12135.1 - 2e-98 329.2 0.0 2.5e-98 328.9 0.0 1.1 1 0 0 1 1 1 1 Peptidase family C54 DUF3558 PF12079.8 ELR12135.1 - 6.9 6.6 10.9 0.14 12.1 3.8 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3558) HPP PF04982.13 ELR12136.1 - 7.2e-07 29.4 7.9 1.6e-05 25.0 2.9 2.6 1 1 2 3 3 3 2 HPP family DUF2981 PF11200.8 ELR12136.1 - 0.18 11.5 1.0 0.21 11.3 1.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2981) FUSC PF04632.12 ELR12136.1 - 3.5 6.1 5.9 0.45 9.0 1.7 1.5 2 0 0 2 2 2 0 Fusaric acid resistance protein family DUF455 PF04305.14 ELR12137.1 - 2.2e-72 243.6 0.0 2.7e-72 243.3 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF455) DUF2561 PF10812.8 ELR12138.1 - 0.045 13.8 0.3 0.086 12.9 0.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2561) DUF4199 PF13858.6 ELR12138.1 - 3.1 8.2 0.0 3.1 8.2 0.0 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF4199) CPDase PF07823.11 ELR12139.1 - 3.6e-17 62.7 0.0 5.4e-17 62.1 0.0 1.2 1 0 0 1 1 1 1 Cyclic phosphodiesterase-like protein 2_5_RNA_ligase2 PF13563.6 ELR12139.1 - 4.9e-09 36.3 0.2 6e-09 36.0 0.2 1.1 1 0 0 1 1 1 1 2'-5' RNA ligase superfamily LigT_PEase PF02834.16 ELR12139.1 - 8.4e-05 22.7 0.0 0.003 17.7 0.0 2.2 2 0 0 2 2 2 1 LigT like Phosphoesterase CLU PF13236.6 ELR12142.1 - 1.4e-39 136.3 0.1 2.3e-38 132.2 0.0 2.7 2 1 0 2 2 2 1 Clustered mitochondria eIF3_p135 PF12807.7 ELR12142.1 - 2.1e-06 27.9 0.0 2.1e-06 27.9 0.0 3.4 3 0 0 3 3 3 1 Translation initiation factor eIF3 subunit 135 DUF5549 PF17703.1 ELR12142.1 - 0.017 14.8 0.5 0.017 14.8 0.5 2.5 3 0 0 3 3 3 0 Family of unknown function (DUF5549) DsbC_N PF10411.9 ELR12142.1 - 0.18 11.2 0.0 0.34 10.4 0.0 1.4 1 0 0 1 1 1 0 Disulfide bond isomerase protein N-terminus F-box-like PF12937.7 ELR12143.1 - 0.00015 21.6 0.2 0.0085 16.0 0.1 2.6 2 0 0 2 2 2 1 F-box-like Svs_4_5_6 PF17381.2 ELR12143.1 - 0.094 13.7 1.1 7.4 7.6 0.3 2.4 2 0 0 2 2 2 0 Seminal vesicle secretory proteins 4/5/6 F-box-like PF12937.7 ELR12144.1 - 0.00084 19.2 0.1 0.0022 17.9 0.1 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ELR12144.1 - 0.083 12.8 0.0 0.31 11.0 0.0 1.9 2 0 0 2 2 2 0 F-box domain F-box-like PF12937.7 ELR12145.1 - 0.014 15.2 0.1 0.031 14.2 0.1 1.6 1 0 0 1 1 1 0 F-box-like LRAT PF04970.13 ELR12146.1 - 0.00027 21.2 0.4 0.0037 17.6 0.0 2.1 2 0 0 2 2 2 1 Lecithin retinol acyltransferase Amidase_6 PF12671.7 ELR12146.1 - 0.063 13.4 0.0 0.092 12.9 0.0 1.2 1 0 0 1 1 1 0 Putative amidase domain CHAP PF05257.16 ELR12146.1 - 0.065 13.8 0.2 0.15 12.7 0.2 1.5 1 0 0 1 1 1 0 CHAP domain Ank_2 PF12796.7 ELR12147.1 - 5.7e-24 84.5 1.6 2.3e-10 40.9 0.0 3.1 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_5 PF13857.6 ELR12147.1 - 8.5e-24 83.3 0.8 1.8e-11 44.0 0.0 4.4 2 1 2 4 4 4 4 Ankyrin repeats (many copies) Ank_4 PF13637.6 ELR12147.1 - 3.1e-17 62.7 0.5 1.1e-07 32.2 0.0 3.9 3 0 0 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 ELR12147.1 - 1.5e-16 58.8 0.3 0.00021 21.4 0.1 4.8 3 1 1 4 4 4 3 Ankyrin repeat Ank PF00023.30 ELR12147.1 - 1.4e-12 47.5 5.6 1.2e-05 25.6 0.2 4.7 4 2 1 5 5 5 3 Ankyrin repeat F-box-like PF12937.7 ELR12147.1 - 1.7e-08 34.2 0.2 5.3e-08 32.6 0.0 2.0 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 ELR12147.1 - 1.4e-06 28.1 0.0 3.1e-06 26.9 0.0 1.6 1 0 0 1 1 1 1 F-box domain Cyclin_N PF00134.23 ELR12147.1 - 0.12 12.1 0.1 0.19 11.5 0.1 1.3 1 0 0 1 1 1 0 Cyclin, N-terminal domain DUF4456 PF14644.6 ELR12147.1 - 0.72 9.5 6.5 1.5 8.4 6.5 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4456) MORN PF02493.20 ELR12148.1 - 1.1e-21 75.4 44.5 2.9e-05 23.7 3.2 6.5 6 0 0 6 6 6 6 MORN repeat F-box-like PF12937.7 ELR12148.1 - 8.5e-09 35.2 2.5 1.5e-08 34.4 2.5 1.4 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ELR12148.1 - 6.6e-07 29.1 1.0 1.3e-06 28.2 1.0 1.5 1 0 0 1 1 1 1 F-box domain Elongin_A PF06881.11 ELR12148.1 - 0.00044 20.7 0.0 0.0011 19.5 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase II transcription factor SIII (Elongin) subunit A F-box_4 PF15966.5 ELR12148.1 - 0.07 13.0 0.0 0.13 12.1 0.0 1.5 1 0 0 1 1 1 0 F-box DUF4477 PF14780.6 ELR12149.1 - 0.0011 18.6 3.3 0.005 16.5 0.8 2.3 1 1 1 2 2 2 2 Domain of unknown function (DUF4477) TFIIS_C PF01096.18 ELR12150.1 - 4.2e-19 68.1 3.3 4.2e-19 68.1 3.3 2.7 3 0 0 3 3 3 1 Transcription factor S-II (TFIIS) RNA_POL_M_15KD PF02150.16 ELR12150.1 - 8.9e-08 31.9 0.9 8.9e-08 31.9 0.9 3.0 3 0 0 3 3 3 1 RNA polymerases M/15 Kd subunit Zn_Tnp_IS1595 PF12760.7 ELR12150.1 - 5.9e-05 23.0 3.4 0.0075 16.2 0.2 2.4 2 0 0 2 2 2 2 Transposase zinc-ribbon domain TF_Zn_Ribbon PF08271.12 ELR12150.1 - 8.9e-05 21.9 4.4 0.012 15.1 0.3 2.7 2 1 0 2 2 2 2 TFIIB zinc-binding Nudix_N_2 PF14803.6 ELR12150.1 - 0.00026 20.9 5.1 0.0045 16.9 0.3 3.1 3 0 0 3 3 3 1 Nudix N-terminal zinc_ribbon_10 PF10058.9 ELR12150.1 - 0.0017 18.0 5.0 1.2 9.0 0.1 3.8 3 1 1 4 4 4 1 Predicted integral membrane zinc-ribbon metal-binding protein Baculo_LEF5_C PF11792.8 ELR12150.1 - 0.0054 16.4 0.3 0.0054 16.4 0.3 1.7 2 0 0 2 2 1 1 Baculoviridae late expression factor 5 C-terminal domain zinc_ribbon_4 PF13717.6 ELR12150.1 - 0.0092 15.9 6.6 1.8 8.6 0.0 3.8 4 0 0 4 4 4 1 zinc-ribbon domain DpnI PF06044.12 ELR12150.1 - 0.013 15.1 6.3 0.31 10.6 0.5 2.1 1 1 1 2 2 2 0 Dam-replacing family Tnp_zf-ribbon_2 PF13842.6 ELR12150.1 - 0.026 15.3 6.9 4.6 8.1 0.2 3.3 3 0 0 3 3 3 0 DDE_Tnp_1-like zinc-ribbon zf-CHY PF05495.12 ELR12150.1 - 0.033 14.7 4.2 0.24 11.9 4.3 2.3 1 1 1 2 2 2 0 CHY zinc finger zf-RRPl_C4 PF17026.5 ELR12150.1 - 0.065 13.3 2.3 0.094 12.8 2.3 1.2 1 0 0 1 1 1 0 Putative ribonucleoprotein zinc-finger pf C4 type Zn-ribbon_8 PF09723.10 ELR12150.1 - 0.078 13.1 11.5 0.43 10.7 0.9 3.9 3 1 0 4 4 4 0 Zinc ribbon domain C1_4 PF07975.12 ELR12150.1 - 0.23 11.7 10.5 1.8 8.8 2.3 3.3 1 1 2 3 3 3 0 TFIIH C1-like domain Zn_ribbon_recom PF13408.6 ELR12150.1 - 0.23 12.0 2.3 13 6.4 0.0 2.6 2 1 0 2 2 2 0 Recombinase zinc beta ribbon domain OrfB_Zn_ribbon PF07282.11 ELR12150.1 - 0.29 11.1 6.0 1 9.3 2.3 2.6 1 1 1 2 2 2 0 Putative transposase DNA-binding domain zf-H2C2_2 PF13465.6 ELR12150.1 - 0.33 11.5 12.8 18 6.0 0.1 4.1 4 0 0 4 4 4 0 Zinc-finger double domain DUF3797 PF12677.7 ELR12150.1 - 0.4 10.6 6.9 2 8.4 3.2 2.9 2 1 0 2 2 2 0 Domain of unknown function (DUF3797) HypA PF01155.19 ELR12150.1 - 0.44 10.6 6.5 2.1 8.4 4.9 2.5 1 1 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-ribbon_3 PF13248.6 ELR12150.1 - 0.61 9.6 12.3 0.75 9.3 0.2 3.6 4 0 0 4 4 4 0 zinc-ribbon domain DZR PF12773.7 ELR12150.1 - 0.63 10.1 12.8 3.8e+02 1.2 12.8 2.9 1 1 0 1 1 1 0 Double zinc ribbon Zn_ribbon_SprT PF17283.2 ELR12150.1 - 0.77 9.7 6.4 14 5.7 3.7 3.0 2 1 0 2 2 2 0 SprT-like zinc ribbon domain zf-IS66 PF13005.7 ELR12150.1 - 1.2 9.6 5.5 9.9 6.7 0.1 2.9 3 0 0 3 3 2 0 zinc-finger binding domain of transposase IS66 zf-Mss51 PF13824.6 ELR12150.1 - 1.5 9.0 6.9 21 5.3 0.4 2.8 1 1 2 3 3 3 0 Zinc-finger of mitochondrial splicing suppressor 51 zf-B_box PF00643.24 ELR12150.1 - 2.4 8.4 11.3 6 7.1 2.1 3.3 3 1 0 3 3 3 0 B-box zinc finger zf-RING_7 PF02591.15 ELR12150.1 - 3 8.1 7.0 4.2 7.6 0.1 2.9 3 0 0 3 3 3 0 C4-type zinc ribbon domain zinc_ribbon_15 PF17032.5 ELR12150.1 - 3.4 8.5 11.8 0.22 12.3 0.6 2.9 1 1 1 3 3 3 0 zinc-ribbon family zinc_ribbon_2 PF13240.6 ELR12150.1 - 4.5 7.1 17.3 0.88 9.4 0.2 3.9 4 0 0 4 4 4 0 zinc-ribbon domain R3H PF01424.22 ELR12151.1 - 0.0099 15.8 0.0 0.015 15.2 0.0 1.4 1 0 0 1 1 1 1 R3H domain DUF4762 PF15959.5 ELR12151.1 - 0.15 12.0 0.0 0.24 11.4 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4762) SAM_1 PF00536.30 ELR12152.1 - 1.8e-17 63.6 0.3 3.1e-17 62.8 0.3 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 ELR12152.1 - 2.4e-12 46.8 0.1 4.1e-12 46.0 0.1 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) PB1 PF00564.24 ELR12152.1 - 2.6e-09 36.9 0.1 4.8e-09 36.0 0.1 1.5 1 0 0 1 1 1 1 PB1 domain PH PF00169.29 ELR12152.1 - 7e-07 29.7 0.1 2.1e-06 28.2 0.0 1.8 2 0 0 2 2 2 1 PH domain SAM_PNT PF02198.16 ELR12152.1 - 0.00051 20.0 0.0 0.0012 18.8 0.0 1.6 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain PH_11 PF15413.6 ELR12152.1 - 0.055 13.9 2.2 0.68 10.4 0.0 3.1 3 2 0 3 3 3 0 Pleckstrin homology domain SAM_3 PF18016.1 ELR12152.1 - 0.061 13.1 0.1 0.24 11.2 0.1 1.9 2 0 0 2 2 2 0 SAM domain (Sterile alpha motif) EF-hand_6 PF13405.6 ELR12153.1 - 6.8e-21 72.4 8.9 5.4e-05 22.8 0.5 4.6 4 0 0 4 4 4 4 EF-hand domain EF-hand_1 PF00036.32 ELR12153.1 - 9.2e-21 71.8 11.4 2.9e-05 23.3 0.5 4.6 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 ELR12153.1 - 1.3e-17 64.0 10.6 1.6e-11 44.5 2.3 3.0 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_8 PF13833.6 ELR12153.1 - 3.9e-17 61.8 5.8 1.7e-06 27.8 0.0 3.6 1 1 2 3 3 3 3 EF-hand domain pair Acyltransferase PF01553.21 ELR12153.1 - 6.8e-16 58.1 0.0 1.1e-15 57.4 0.0 1.3 1 0 0 1 1 1 1 Acyltransferase EF-hand_5 PF13202.6 ELR12153.1 - 8.5e-13 47.2 15.7 0.0016 17.8 0.4 4.6 4 0 0 4 4 4 4 EF hand SPARC_Ca_bdg PF10591.9 ELR12153.1 - 0.00033 21.0 4.9 0.0025 18.1 0.3 2.7 3 0 0 3 3 3 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_9 PF14658.6 ELR12153.1 - 0.0043 17.3 0.2 0.36 11.2 0.1 3.3 3 1 0 3 3 3 1 EF-hand domain DUF4400 PF14348.6 ELR12153.1 - 0.056 13.0 1.6 0.088 12.3 1.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4400) EF-hand_4 PF12763.7 ELR12153.1 - 0.099 12.6 3.3 0.49 10.4 0.3 2.9 1 1 0 2 2 2 0 Cytoskeletal-regulatory complex EF hand p25-alpha PF05517.12 ELR12153.1 - 0.15 12.2 0.0 11 6.2 0.0 2.3 2 0 0 2 2 2 0 p25-alpha Solute_trans_a PF03619.16 ELR12154.1 - 1e-84 284.2 4.4 1.4e-84 283.7 4.4 1.2 1 0 0 1 1 1 1 Organic solute transporter Ostalpha PARP_reg PF02877.14 ELR12155.1 - 7e-20 71.5 2.5 8.6e-20 71.2 0.9 2.0 2 0 0 2 2 2 1 Poly(ADP-ribose) polymerase, regulatory domain PARP PF00644.20 ELR12155.1 - 3.6e-16 59.3 0.0 2.9e-12 46.6 0.0 3.7 3 1 1 4 4 4 2 Poly(ADP-ribose) polymerase catalytic domain BRCT PF00533.26 ELR12155.1 - 4.5e-16 59.0 0.0 2.3e-06 27.9 0.0 3.3 2 0 0 2 2 2 2 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 ELR12155.1 - 2.6e-15 56.6 0.0 2.3e-06 27.9 0.0 3.3 2 0 0 2 2 2 2 BRCT domain, a BRCA1 C-terminus domain PTCB-BRCT PF12738.7 ELR12155.1 - 4.4e-09 36.1 0.1 0.0057 16.6 0.0 2.7 2 0 0 2 2 2 2 twin BRCT domain RNA_ligase PF09414.10 ELR12155.1 - 4.6e-08 33.5 0.0 0.00016 22.0 0.0 3.6 3 1 0 3 3 3 1 RNA ligase WGR PF05406.15 ELR12155.1 - 1.6e-05 24.9 1.5 0.28 11.3 0.3 3.8 2 1 0 2 2 2 2 WGR domain RNA_pol_Rpb2_2 PF04561.14 ELR12155.1 - 0.0016 18.1 0.9 1.8 8.1 0.1 2.8 2 0 0 2 2 2 2 RNA polymerase Rpb2, domain 2 Dishevelled PF02377.15 ELR12155.1 - 0.002 18.6 39.4 0.17 12.3 17.9 2.7 2 0 0 2 2 2 2 Dishevelled specific domain EpmC PF04315.12 ELR12155.1 - 0.03 14.0 0.1 12 5.6 0.0 2.5 2 0 0 2 2 2 0 Elongation factor P hydroxylase aGPT-Pplase2 PF18724.1 ELR12155.1 - 0.072 12.8 1.0 15 5.2 0.1 2.9 2 0 0 2 2 2 0 Alpha-glutamyl/putrescinyl thymine pyrophosphorylase clade 2 23S_rRNA_IVP PF05635.11 ELR12155.1 - 0.09 13.1 0.2 31 4.9 0.0 2.9 3 0 0 3 3 2 0 23S rRNA-intervening sequence protein PTPS PF01242.19 ELR12155.1 - 0.13 12.2 0.3 28 4.7 0.0 2.7 2 0 0 2 2 2 0 6-pyruvoyl tetrahydropterin synthase SHNi-TPR PF10516.9 ELR12155.1 - 1.5 8.3 6.4 13 5.3 0.7 2.6 2 0 0 2 2 2 0 SHNi-TPR GATA PF00320.27 ELR12156.1 - 4e-15 55.1 3.4 7.5e-15 54.3 3.4 1.5 1 0 0 1 1 1 1 GATA zinc finger zf-C2H2_11 PF16622.5 ELR12156.1 - 0.0096 15.7 1.0 3.6 7.4 0.1 2.7 2 0 0 2 2 2 2 zinc-finger C2H2-type Zn-ribbon_8 PF09723.10 ELR12156.1 - 0.048 13.8 0.7 0.093 12.9 0.7 1.5 1 0 0 1 1 1 0 Zinc ribbon domain Kelch_4 PF13418.6 ELR12157.1 - 2e-44 149.3 17.1 4.7e-11 42.5 0.0 6.5 6 0 0 6 6 6 6 Galactose oxidase, central domain Kelch_3 PF13415.6 ELR12157.1 - 2.4e-43 145.6 15.8 3.2e-13 49.6 0.0 7.3 7 0 0 7 7 7 5 Galactose oxidase, central domain Kelch_5 PF13854.6 ELR12157.1 - 9e-41 137.3 10.7 2.4e-06 27.4 0.0 6.5 6 0 0 6 6 6 6 Kelch motif Kelch_1 PF01344.25 ELR12157.1 - 5.5e-33 112.3 11.9 2e-06 27.3 0.1 6.2 6 0 0 6 6 6 5 Kelch motif Kelch_6 PF13964.6 ELR12157.1 - 2.6e-30 103.7 14.1 2.6e-06 27.5 0.0 6.4 5 1 1 6 6 6 5 Kelch motif Kelch_2 PF07646.15 ELR12157.1 - 1.4e-23 81.9 19.1 1.2e-05 25.0 0.1 6.5 6 0 0 6 6 6 5 Kelch motif Endostatin PF06482.11 ELR12157.1 - 1.3 8.4 4.3 0.29 10.5 0.2 2.0 2 0 0 2 2 2 0 Collagenase NC10 and Endostatin PIG-U PF06728.13 ELR12158.1 - 1.9e-103 346.5 39.0 2.3e-103 346.2 39.0 1.1 1 0 0 1 1 1 1 GPI transamidase subunit PIG-U DUF1180 PF06679.12 ELR12158.1 - 0.0059 17.0 1.3 0.16 12.4 0.3 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF1180) Ac76 PF05814.11 ELR12158.1 - 0.19 11.7 1.8 0.32 11.0 0.0 2.3 3 0 0 3 3 3 0 Orf76 (Ac76) HMG_box PF00505.19 ELR12159.1 - 2.4e-12 47.1 0.4 2.9e-12 46.8 0.4 1.1 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 ELR12159.1 - 4.2e-10 40.1 0.6 5.4e-10 39.7 0.6 1.1 1 0 0 1 1 1 1 HMG-box domain Peptidase_C78 PF07910.13 ELR12159.1 - 0.074 12.5 0.0 0.084 12.3 0.0 1.1 1 0 0 1 1 1 0 Peptidase family C78 BCS1_N PF08740.11 ELR12161.1 - 1e-28 100.6 0.1 1e-28 100.6 0.1 1.9 2 0 0 2 2 1 1 BCS1 N terminal AAA PF00004.29 ELR12161.1 - 2.5e-17 63.5 0.0 1.6e-16 60.9 0.0 2.3 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 ELR12161.1 - 0.00012 22.5 2.1 0.01 16.3 0.0 2.4 2 0 0 2 2 2 1 AAA ATPase domain AAA_11 PF13086.6 ELR12161.1 - 0.00023 21.0 2.8 0.11 12.2 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_23 PF13476.6 ELR12161.1 - 0.014 15.9 2.5 0.052 14.1 2.5 1.8 1 1 0 1 1 1 0 AAA domain DUF815 PF05673.13 ELR12161.1 - 0.027 13.6 0.0 0.053 12.7 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF815) Rrn6 PF10214.9 ELR12161.1 - 0.036 12.6 1.2 0.041 12.4 1.2 1.1 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor ATPase PF06745.13 ELR12161.1 - 0.044 13.1 0.0 0.087 12.2 0.0 1.4 1 0 0 1 1 1 0 KaiC AAA_5 PF07728.14 ELR12161.1 - 0.048 13.6 0.0 0.11 12.4 0.0 1.7 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) RNA_helicase PF00910.22 ELR12161.1 - 0.067 13.6 0.0 0.23 11.9 0.0 1.9 2 0 0 2 2 2 0 RNA helicase AAA_33 PF13671.6 ELR12161.1 - 0.089 13.0 9.1 1.4 9.1 8.5 2.6 1 1 0 1 1 1 0 AAA domain TsaE PF02367.17 ELR12161.1 - 0.091 12.8 0.0 0.31 11.1 0.0 1.9 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE NACHT PF05729.12 ELR12161.1 - 0.11 12.4 0.0 0.33 10.9 0.0 1.8 1 0 0 1 1 1 0 NACHT domain AAA_7 PF12775.7 ELR12161.1 - 0.14 11.7 0.0 0.24 10.9 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_18 PF13238.6 ELR12161.1 - 0.78 10.3 0.0 0.78 10.3 0.0 3.1 2 1 0 2 2 1 0 AAA domain Peptidase_M14 PF00246.24 ELR12162.1 - 2.2e-61 208.2 0.3 5.2e-61 207.0 0.0 1.8 2 0 0 2 2 2 1 Zinc carboxypeptidase AstE_AspA PF04952.14 ELR12162.1 - 0.00011 21.3 0.6 0.00039 19.6 0.1 2.1 3 0 0 3 3 3 1 Succinylglutamate desuccinylase / Aspartoacylase family Pox_A11 PF05061.13 ELR12162.1 - 0.07 12.4 0.2 0.15 11.3 0.1 1.4 1 1 0 1 1 1 0 Poxvirus A11 Protein RskA PF10099.9 ELR12162.1 - 0.21 11.8 6.4 0.27 11.5 4.2 2.0 2 0 0 2 2 2 0 Anti-sigma-K factor rskA ST7 PF04184.12 ELR12162.1 - 0.43 9.0 5.0 0.61 8.5 5.0 1.1 1 0 0 1 1 1 0 ST7 protein DUF2817 PF10994.8 ELR12162.1 - 0.5 9.7 5.8 0.12 11.8 0.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2817) SURF6 PF04935.12 ELR12162.1 - 0.53 10.0 8.7 0.8 9.5 8.7 1.2 1 0 0 1 1 1 0 Surfeit locus protein 6 IHABP4_N PF16174.5 ELR12162.1 - 3.5 8.2 10.0 2 9.0 4.8 2.3 2 0 0 2 2 2 0 Intracellular hyaluronan-binding protein 4 N-terminal K_channel_TID PF07941.11 ELR12162.1 - 8 7.0 17.3 6.6 7.3 9.9 2.5 2 0 0 2 2 2 0 Potassium channel Kv1.4 tandem inactivation domain GATA PF00320.27 ELR12163.1 - 7.4e-16 57.5 3.5 1.3e-15 56.6 3.5 1.5 1 0 0 1 1 1 1 GATA zinc finger zf-C2H2_11 PF16622.5 ELR12163.1 - 0.0003 20.5 1.8 0.16 11.7 0.4 2.5 2 0 0 2 2 2 2 zinc-finger C2H2-type Zn-ribbon_8 PF09723.10 ELR12163.1 - 0.0004 20.5 2.1 0.0039 17.3 0.4 2.3 2 0 0 2 2 2 1 Zinc ribbon domain zf-C2H2_3 PF13878.6 ELR12163.1 - 0.1 12.4 0.1 0.87 9.5 0.0 2.2 2 0 0 2 2 2 0 zinc-finger of acetyl-transferase ESCO zf-HYPF PF07503.12 ELR12163.1 - 0.12 12.1 2.1 6.9 6.5 0.1 2.3 2 0 0 2 2 2 0 HypF finger DZR PF12773.7 ELR12163.1 - 0.25 11.4 2.4 0.49 10.5 2.4 1.6 1 1 0 1 1 1 0 Double zinc ribbon zf-C2H2_4 PF13894.6 ELR12163.1 - 1.3 10.1 4.5 3.5 8.7 0.3 2.8 3 0 0 3 3 3 0 C2H2-type zinc finger Sulfotransfer_3 PF13469.6 ELR12164.1 - 5.6e-05 23.6 0.5 0.00012 22.5 0.5 1.5 1 0 0 1 1 1 1 Sulfotransferase family Sulfotransfer_1 PF00685.27 ELR12164.1 - 0.0025 17.4 1.2 0.0039 16.7 1.2 1.4 1 1 0 1 1 1 1 Sulfotransferase domain Mcm10 PF09332.11 ELR12164.1 - 1.3 8.3 3.8 1.2 8.5 0.1 2.0 2 0 0 2 2 2 0 Mcm10 replication factor F-box-like PF12937.7 ELR12165.1 - 2.5e-06 27.3 0.0 4.6e-06 26.4 0.0 1.5 1 0 0 1 1 1 1 F-box-like Elongin_A PF06881.11 ELR12165.1 - 0.0004 20.9 0.0 0.00078 19.9 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase II transcription factor SIII (Elongin) subunit A F-box PF00646.33 ELR12165.1 - 0.001 18.9 0.2 0.0024 17.7 0.1 1.6 2 0 0 2 2 2 1 F-box domain Metallophos PF00149.28 ELR12166.1 - 1.1e-10 42.4 0.0 1.4e-10 42.1 0.0 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 ELR12166.1 - 7.5e-05 23.0 0.0 0.0021 18.3 0.0 2.2 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Isochorismatase PF00857.20 ELR12167.1 - 2.4e-19 70.2 0.1 1.8e-11 44.5 0.1 2.1 2 0 0 2 2 2 2 Isochorismatase family WD40 PF00400.32 ELR12168.1 - 6.1e-23 80.7 21.5 2.5e-06 28.1 0.1 7.2 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ELR12168.1 - 5.9e-19 68.2 7.3 3.1e-10 40.2 0.2 4.4 2 1 2 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ELR12168.1 - 0.00035 19.6 1.6 0.53 9.2 0.3 4.4 1 1 2 3 3 3 1 WD40 region of Ge1, enhancer of mRNA-decapping protein IKI3 PF04762.12 ELR12168.1 - 0.0089 14.1 0.3 0.12 10.4 0.1 2.2 2 0 0 2 2 2 1 IKI3 family DPPIV_N PF00930.21 ELR12168.1 - 0.058 12.1 0.7 0.22 10.3 0.2 2.1 1 1 1 2 2 2 0 Dipeptidyl peptidase IV (DPP IV) N-terminal region Glyco_hydro_10 PF00331.20 ELR12169.1 - 3.1e-11 43.0 0.1 4e-11 42.6 0.1 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 10 EIIC-GAT PF03611.14 ELR12170.1 - 0.091 11.8 0.1 0.12 11.5 0.1 1.1 1 0 0 1 1 1 0 PTS system sugar-specific permease component SH3_1 PF00018.28 ELR12171.1 - 3.2e-22 77.9 2.5 4.5e-13 48.6 0.1 2.9 3 0 0 3 3 3 2 SH3 domain SH3_9 PF14604.6 ELR12171.1 - 1.3e-21 76.1 2.6 1.2e-12 47.5 0.2 2.6 2 1 0 2 2 2 2 Variant SH3 domain SH3_2 PF07653.17 ELR12171.1 - 3.2e-21 74.8 0.4 1.1e-10 41.0 0.0 2.4 2 0 0 2 2 2 2 Variant SH3 domain Anti-adapt_IraP PF10796.9 ELR12171.1 - 0.18 12.4 2.0 0.24 12.0 0.2 2.2 2 0 0 2 2 2 0 Sigma-S stabilisation anti-adaptor protein Cauli_AT PF03233.13 ELR12171.1 - 8.3 6.3 9.0 11 6.0 3.7 2.4 2 0 0 2 2 2 0 Aphid transmission protein CH PF00307.31 ELR12172.1 - 5.6e-33 113.4 0.1 1e-15 57.8 0.0 2.2 2 0 0 2 2 2 2 Calponin homology (CH) domain CAMSAP_CH PF11971.8 ELR12172.1 - 1.2e-11 44.3 0.2 0.00012 21.8 0.0 2.3 2 0 0 2 2 2 2 CAMSAP CH domain CH_2 PF06294.11 ELR12172.1 - 0.0008 19.5 0.0 0.14 12.3 0.0 2.6 2 1 0 2 2 2 2 CH-like domain in sperm protein SAM_2 PF07647.17 ELR12173.1 - 6.1e-07 29.4 0.0 1.1e-06 28.7 0.0 1.3 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 ELR12173.1 - 6.5e-07 29.7 0.0 1e-06 29.1 0.0 1.3 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Prok_Ub PF14454.6 ELR12173.1 - 0.03 14.0 0.1 0.068 12.8 0.1 1.5 1 0 0 1 1 1 0 Prokaryotic Ubiquitin Glyco_hydro_20 PF00728.22 ELR12174.1 - 1.6e-51 175.8 0.0 3.9e-49 167.9 0.0 2.1 1 1 0 1 1 1 1 Glycosyl hydrolase family 20, catalytic domain Glycohydro_20b2 PF14845.6 ELR12174.1 - 8.9e-05 23.2 0.1 0.0018 18.9 0.1 2.9 2 1 0 2 2 2 1 beta-acetyl hexosaminidase like PTEN_C2 PF10409.9 ELR12175.1 - 0.0011 18.7 0.0 0.002 17.9 0.0 1.4 1 0 0 1 1 1 1 C2 domain of PTEN tumour-suppressor protein DSPc PF00782.20 ELR12175.1 - 0.081 12.7 0.0 0.13 12.1 0.0 1.3 1 0 0 1 1 1 0 Dual specificity phosphatase, catalytic domain RPA43_OB PF17875.1 ELR12177.1 - 1.5e-15 57.9 0.0 1.5e-15 57.9 0.0 2.8 2 1 0 2 2 2 1 RPA43 OB domain in RNA Pol I SHS2_Rpb7-N PF03876.17 ELR12177.1 - 0.00014 22.1 0.0 0.00029 21.2 0.0 1.5 1 0 0 1 1 1 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 FAM176 PF14851.6 ELR12177.1 - 0.062 13.0 0.3 0.062 13.0 0.3 2.9 2 1 1 3 3 3 0 FAM176 family Myc_N PF01056.18 ELR12177.1 - 1.4 8.8 17.9 0.96 9.3 0.4 2.1 2 0 0 2 2 2 0 Myc amino-terminal region DUF4820 PF16091.5 ELR12177.1 - 1.5 8.2 13.5 0.92 8.8 5.5 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4820) RNA_polI_A34 PF08208.11 ELR12177.1 - 2 8.5 34.0 0.72 9.9 26.9 2.1 2 0 0 2 2 2 0 DNA-directed RNA polymerase I subunit RPA34.5 Coilin_N PF15862.5 ELR12177.1 - 4.3 7.2 22.7 13 5.6 17.9 2.2 2 0 0 2 2 2 0 Coilin N-terminus PTPRCAP PF15713.5 ELR12177.1 - 4.7 7.5 23.1 5.4 7.3 2.2 2.2 2 0 0 2 2 2 0 Protein tyrosine phosphatase receptor type C-associated Oleosin PF01277.17 ELR12178.1 - 0.039 13.7 3.6 0.17 11.6 0.1 2.6 2 1 1 3 3 3 0 Oleosin DUF883 PF05957.13 ELR12178.1 - 0.23 12.1 5.3 0.19 12.3 2.0 2.3 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF883) EXS PF03124.14 ELR12179.1 - 1e-91 307.8 20.7 1.4e-91 307.3 20.7 1.2 1 0 0 1 1 1 1 EXS family SPX PF03105.19 ELR12179.1 - 1.3e-20 74.7 16.1 9.2e-09 35.7 1.7 3.3 1 1 2 3 3 3 3 SPX domain GAS PF13851.6 ELR12179.1 - 0.12 11.7 0.6 0.22 10.9 0.6 1.3 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding HECT PF00632.25 ELR12180.1 - 8e-83 278.4 0.0 1e-82 278.1 0.0 1.1 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) SPX PF03105.19 ELR12180.1 - 1.4 8.8 5.9 2.3 8.0 5.9 1.3 1 0 0 1 1 1 0 SPX domain SSP160 PF06933.11 ELR12180.1 - 8.4 4.5 13.2 13 3.8 13.2 1.2 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 DSBA PF01323.20 ELR12182.1 - 1.8e-13 50.7 0.2 2.5e-11 43.7 0.0 2.1 2 0 0 2 2 2 2 DSBA-like thioredoxin domain DUF742 PF05331.11 ELR12183.1 - 0.074 12.9 0.0 0.17 11.7 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF742) AMPK1_CBM PF16561.5 ELR12184.1 - 6.5e-35 119.2 1.2 3.2e-34 117.0 0.6 2.1 2 0 0 2 2 2 1 Glycogen recognition site of AMP-activated protein kinase AMPKBI PF04739.15 ELR12184.1 - 9.1e-13 48.3 4.7 1.7e-11 44.2 0.9 2.4 2 0 0 2 2 2 2 5'-AMP-activated protein kinase beta subunit, interaction domain CBM53 PF16760.5 ELR12184.1 - 0.13 12.8 1.0 2 9.0 0.2 2.3 2 0 0 2 2 2 0 Starch/carbohydrate-binding module (family 53) Mito_carr PF00153.27 ELR12185.1 - 4.4e-55 183.6 0.7 1.3e-20 73.1 0.1 4.0 4 0 0 4 4 4 4 Mitochondrial carrier protein Rieske PF00355.26 ELR12186.1 - 1.1e-18 66.9 0.0 2.1e-18 66.0 0.0 1.5 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain Inhibitor_I10 PF12559.8 ELR12187.1 - 0.003 17.8 0.7 0.0056 16.9 0.7 1.3 1 0 0 1 1 1 1 Serine endopeptidase inhibitors SPT6_acidic PF14632.6 ELR12187.1 - 0.0069 16.9 3.5 0.011 16.3 3.5 1.3 1 0 0 1 1 1 1 Acidic N-terminal SPT6 MFS_1 PF07690.16 ELR12189.1 - 2.8e-37 128.5 58.0 4e-31 108.2 33.8 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily PaO PF08417.12 ELR12190.1 - 2.7e-11 43.4 0.1 4.7e-11 42.7 0.1 1.4 1 0 0 1 1 1 1 Pheophorbide a oxygenase Rieske PF00355.26 ELR12190.1 - 4.3e-10 39.4 0.0 8.8e-10 38.4 0.0 1.5 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain LSM_int_assoc PF16605.5 ELR12190.1 - 0.068 13.3 0.4 0.16 12.1 0.4 1.6 1 0 0 1 1 1 0 LSM-interacting associated unstructured GCP_C_terminal PF04130.13 ELR12191.1 - 2.2e-36 125.9 4.3 2.7e-36 125.6 4.3 1.1 1 0 0 1 1 1 1 Gamma tubulin complex component C-terminal RsbU_N PF08673.10 ELR12191.1 - 0.055 13.6 0.1 0.35 11.0 0.0 2.2 2 0 0 2 2 2 0 Phosphoserine phosphatase RsbU, N-terminal domain Josephin PF02099.17 ELR12191.1 - 0.071 13.2 0.1 0.12 12.5 0.1 1.4 1 1 0 1 1 1 0 Josephin GCP_N_terminal PF17681.1 ELR12192.1 - 2.5e-73 247.4 0.0 3.4e-73 247.0 0.0 1.2 1 0 0 1 1 1 1 Gamma tubulin complex component N-terminal GCP_C_terminal PF04130.13 ELR12192.1 - 2.9e-12 46.7 0.0 5.9e-12 45.7 0.0 1.5 1 0 0 1 1 1 1 Gamma tubulin complex component C-terminal SUKH-4 PF14435.6 ELR12192.1 - 0.0046 17.0 0.0 0.0099 15.9 0.0 1.5 1 0 0 1 1 1 1 SUKH-4 immunity protein QueF_N PF14819.6 ELR12192.1 - 0.033 14.5 0.0 0.071 13.4 0.0 1.5 1 0 0 1 1 1 0 Nitrile reductase, 7-cyano-7-deazaguanine-reductase N-term adh_short PF00106.25 ELR12194.1 - 3.9e-23 81.9 1.3 4.2e-23 81.8 1.3 1.0 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ELR12194.1 - 1.3e-13 51.1 0.1 1.6e-13 50.8 0.1 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ELR12194.1 - 7.5e-10 39.0 0.8 9.8e-10 38.6 0.8 1.0 1 0 0 1 1 1 1 KR domain Pyr_redox PF00070.27 ELR12194.1 - 0.014 15.9 0.2 0.027 15.0 0.2 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase 3HCDH_N PF02737.18 ELR12194.1 - 0.016 15.1 0.2 0.018 14.9 0.2 1.2 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Polysacc_synt_2 PF02719.15 ELR12194.1 - 0.029 13.5 0.0 0.038 13.1 0.0 1.1 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein 3Beta_HSD PF01073.19 ELR12194.1 - 0.087 11.8 0.3 0.099 11.6 0.3 1.1 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family 2-Hacid_dh_C PF02826.19 ELR12194.1 - 0.087 12.2 0.3 0.14 11.5 0.3 1.4 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Epimerase PF01370.21 ELR12194.1 - 0.12 11.8 0.2 0.13 11.7 0.2 1.1 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family KCNQ_channel PF03520.14 ELR12195.1 - 0.06 13.2 0.1 0.079 12.8 0.1 1.3 1 0 0 1 1 1 0 KCNQ voltage-gated potassium channel LRR_4 PF12799.7 ELR12196.1 - 0.00045 20.6 1.2 0.85 10.1 0.0 3.0 2 0 0 2 2 2 2 Leucine Rich repeats (2 copies) Y_phosphatase3 PF13350.6 ELR12197.1 - 2.4e-32 112.8 0.0 4.6e-32 111.8 0.0 1.4 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase2 PF03162.13 ELR12197.1 - 2.1e-05 24.1 0.0 4.9e-05 23.0 0.0 1.5 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase PF00102.27 ELR12197.1 - 0.02 14.4 0.0 0.045 13.3 0.0 1.5 1 0 0 1 1 1 0 Protein-tyrosine phosphatase Macoilin PF09726.9 ELR12197.1 - 0.74 8.3 18.9 1 7.9 18.9 1.1 1 0 0 1 1 1 0 Macoilin family SAPS PF04499.15 ELR12197.1 - 2.9 6.6 7.3 4.1 6.1 7.3 1.3 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein PIG-Y PF15159.6 ELR12198.1 - 9.3e-18 64.9 7.7 1.1e-17 64.6 7.7 1.1 1 0 0 1 1 1 1 Phosphatidylinositol N-acetylglucosaminyltransferase subunit Y Complex1_LYR PF05347.15 ELR12199.1 - 8.2e-10 38.6 0.4 1.1e-09 38.2 0.4 1.3 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_2 PF13233.6 ELR12199.1 - 0.0039 17.9 0.2 0.006 17.3 0.2 1.3 1 0 0 1 1 1 1 Complex1_LYR-like DUF3395 PF11875.8 ELR12200.1 - 1.3e-06 28.4 0.0 0.00074 19.4 0.0 2.8 2 2 0 2 2 2 2 Domain of unknown function (DUF3395) Gal_Lectin PF02140.18 ELR12200.1 - 0.036 14.5 0.0 1.1 9.7 0.0 2.9 3 0 0 3 3 3 0 Galactose binding lectin domain Cellulase PF00150.18 ELR12201.1 - 3.1e-44 151.5 0.2 3.9e-44 151.2 0.2 1.1 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) Glyco_hydro_53 PF07745.13 ELR12201.1 - 0.12 11.3 0.0 0.18 10.8 0.0 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase family 53 DUF1505 PF07403.11 ELR12201.1 - 0.14 12.3 0.3 0.29 11.3 0.1 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1505) SAM_1 PF00536.30 ELR12202.1 - 1.9e-11 44.3 0.0 4.4e-11 43.1 0.0 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) AAA PF00004.29 ELR12202.1 - 4.6e-11 43.3 1.4 4.6e-11 43.3 1.4 2.8 3 1 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) SAM_2 PF07647.17 ELR12202.1 - 8.7e-09 35.4 0.0 2.9e-08 33.7 0.0 2.0 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Zot PF05707.12 ELR12202.1 - 0.00061 19.5 0.0 0.0015 18.2 0.0 1.7 1 0 0 1 1 1 1 Zonular occludens toxin (Zot) SAM_PNT PF02198.16 ELR12202.1 - 0.026 14.5 0.1 0.093 12.7 0.0 1.9 2 0 0 2 2 2 0 Sterile alpha motif (SAM)/Pointed domain Tub_N PF16322.5 ELR12202.1 - 0.45 10.9 7.5 0.83 10.0 7.5 1.3 1 0 0 1 1 1 0 Tubby N-terminal BUD22 PF09073.10 ELR12202.1 - 0.71 9.2 16.5 1.1 8.5 16.5 1.2 1 0 0 1 1 1 0 BUD22 AAA PF00004.29 ELR12203.1 - 3.8e-05 24.1 0.0 6.1e-05 23.5 0.0 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Exo_endo_phos PF03372.23 ELR12204.1 - 0.034 13.7 0.1 0.042 13.4 0.1 1.2 1 0 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family IL12p40_C PF10420.9 ELR12206.1 - 0.0055 17.2 0.1 0.31 11.6 0.1 2.6 2 0 0 2 2 2 1 Cytokine interleukin-12p40 C-terminus Peptidase_M24 PF00557.24 ELR12207.1 - 1.1e-39 136.3 0.1 1.5e-39 135.8 0.1 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 SRP-alpha_N PF04086.13 ELR12207.1 - 2.5 7.9 13.2 6.2 6.6 13.1 1.7 2 0 0 2 2 2 0 Signal recognition particle, alpha subunit, N-terminal GP38 PF05268.11 ELR12207.1 - 6.4 6.3 15.7 12 5.4 15.7 1.4 1 0 0 1 1 1 0 Phage tail fibre adhesin Gp38 IL12p40_C PF10420.9 ELR12208.1 - 0.11 13.0 0.1 3.9 8.1 0.0 2.5 2 0 0 2 2 2 0 Cytokine interleukin-12p40 C-terminus Peptidase_M24 PF00557.24 ELR12209.1 - 1.4e-38 132.7 0.1 1.9e-38 132.3 0.1 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 SRP-alpha_N PF04086.13 ELR12209.1 - 2.3 8.1 16.8 19 5.1 18.0 1.8 2 0 0 2 2 2 0 Signal recognition particle, alpha subunit, N-terminal TIMELESS_C PF05029.13 ELR12209.1 - 5.4 6.1 6.9 1.9 7.5 3.9 1.7 1 1 0 1 1 1 0 Timeless protein C terminal region YueH PF14166.6 ELR12210.1 - 0.018 14.9 0.7 18 5.3 0.1 3.5 1 1 3 4 4 4 0 YueH-like protein SCO1-SenC PF02630.14 ELR12210.1 - 0.042 13.8 1.6 0.055 13.4 0.2 1.9 2 0 0 2 2 2 0 SCO1/SenC Sm_multidrug_ex PF06695.11 ELR12210.1 - 0.052 14.2 0.1 0.13 12.9 0.1 1.6 1 0 0 1 1 1 0 Putative small multi-drug export protein SKG6 PF08693.10 ELR12210.1 - 0.076 12.4 10.4 0.14 11.6 10.4 1.4 1 0 0 1 1 1 0 Transmembrane alpha-helix domain DUF4448 PF14610.6 ELR12210.1 - 0.079 12.7 0.1 0.15 11.8 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4448) Carn_acyltransf PF00755.20 ELR12211.1 - 5.5e-186 619.7 0.0 6.2e-186 619.5 0.0 1.0 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase CTC1 PF15489.6 ELR12212.1 - 4.2e-14 51.1 3.1 5e-09 34.3 0.0 3.7 4 0 0 4 4 4 3 CST, telomere maintenance, complex subunit CTC1 CTC1_2 PF15491.6 ELR12212.1 - 1.8e-05 24.2 0.0 0.00011 21.6 0.0 2.2 3 0 0 3 3 3 1 CST, telomere maintenance, complex subunit CTC1 Sortilin-Vps10 PF15902.5 ELR12213.1 - 1.3e-74 251.7 1.5 1.6e-74 251.3 1.5 1.1 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, Sortilin_C PF15901.5 ELR12213.1 - 2.9e-23 83.1 12.0 2.6e-22 80.0 12.0 2.0 1 1 0 1 1 1 1 Sortilin, neurotensin receptor 3, C-terminal BNR_2 PF13088.6 ELR12213.1 - 0.00044 19.6 0.2 0.0035 16.7 0.2 2.1 2 0 0 2 2 2 1 BNR repeat-like domain BNR PF02012.20 ELR12213.1 - 0.00081 19.0 18.1 0.16 12.0 0.2 6.8 6 0 0 6 6 6 2 BNR/Asp-box repeat PSII_BNR PF14870.6 ELR12213.1 - 0.021 14.1 1.0 0.27 10.5 0.1 2.8 1 1 0 2 2 2 0 Photosynthesis system II assembly factor YCF48 DUF1266 PF06889.11 ELR12213.1 - 0.034 14.2 0.0 0.062 13.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1266) SlyX PF04102.12 ELR12214.1 - 0.0018 18.8 5.1 0.0031 18.1 5.1 1.3 1 0 0 1 1 1 1 SlyX Spc7 PF08317.11 ELR12214.1 - 0.004 16.1 0.4 0.0046 15.9 0.4 1.1 1 0 0 1 1 1 1 Spc7 kinetochore protein USP8_interact PF08941.10 ELR12214.1 - 0.0066 16.3 1.1 0.0099 15.7 1.1 1.2 1 0 0 1 1 1 1 USP8 interacting FliD_N PF02465.18 ELR12214.1 - 0.009 16.7 0.1 0.013 16.2 0.1 1.3 1 0 0 1 1 1 1 Flagellar hook-associated protein 2 N-terminus zf-TRAF_2 PF15965.5 ELR12214.1 - 0.01 16.3 0.6 0.016 15.7 0.6 1.3 1 0 0 1 1 1 1 TRAF-like zinc-finger KxDL PF10241.9 ELR12214.1 - 0.017 15.4 0.8 0.033 14.5 0.8 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein YscO-like PF16789.5 ELR12214.1 - 0.024 14.6 2.0 0.039 14.0 2.0 1.2 1 0 0 1 1 1 0 YscO-like protein FlgN PF05130.12 ELR12214.1 - 0.028 14.9 2.9 0.043 14.3 2.9 1.2 1 0 0 1 1 1 0 FlgN protein CCDC23 PF15674.5 ELR12214.1 - 0.028 14.4 3.2 0.055 13.5 3.2 1.4 1 1 0 1 1 1 0 Coiled-coil domain-containing protein 23 DUF641 PF04859.12 ELR12214.1 - 0.033 14.5 1.3 0.047 14.0 1.3 1.2 1 0 0 1 1 1 0 Plant protein of unknown function (DUF641) zf-TRAF PF02176.18 ELR12214.1 - 0.15 12.8 2.0 0.26 12.0 2.0 1.4 1 0 0 1 1 1 0 TRAF-type zinc finger Phage_Gp23 PF10669.9 ELR12214.1 - 0.18 12.1 2.3 0.37 11.1 2.3 1.5 1 0 0 1 1 1 0 Protein gp23 (Bacteriophage A118) bZIP_1 PF00170.21 ELR12214.1 - 0.3 11.2 4.2 0.42 10.7 4.2 1.2 1 0 0 1 1 1 0 bZIP transcription factor DUF4191 PF13829.6 ELR12214.1 - 0.75 9.1 2.4 0.34 10.2 0.2 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4191) DUF3395 PF11875.8 ELR12215.1 - 4.2e-05 23.5 0.0 0.058 13.3 0.0 2.6 2 2 0 2 2 2 2 Domain of unknown function (DUF3395) Moulting_cycle PF04870.16 ELR12215.1 - 0.023 14.0 0.0 3.2 7.0 0.0 2.1 2 0 0 2 2 2 0 Moulting cycle Metallophos PF00149.28 ELR12216.1 - 2.7e-11 44.4 0.1 2e-10 41.5 0.1 2.0 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 ELR12216.1 - 2.9e-05 24.3 0.0 0.00021 21.6 0.0 2.1 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Gtr1_RagA PF04670.12 ELR12216.1 - 0.00018 20.9 0.1 0.0003 20.2 0.1 1.3 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Peptidase_S9_N PF02897.15 ELR12216.1 - 0.12 11.1 0.1 0.23 10.2 0.0 1.4 2 0 0 2 2 2 0 Prolyl oligopeptidase, N-terminal beta-propeller domain REC114-like PF15165.6 ELR12217.1 - 0.053 13.3 1.7 2.7 7.7 0.1 2.0 1 1 1 2 2 2 0 Meiotic recombination protein REC114-like 5_nucleotid_C PF02872.18 ELR12218.1 - 1.1e-28 100.5 0.0 9.4e-28 97.4 0.0 2.0 1 1 0 1 1 1 1 5'-nucleotidase, C-terminal domain CCDC92 PF14916.6 ELR12218.1 - 0.025 14.3 0.3 0.058 13.2 0.3 1.6 1 0 0 1 1 1 0 Coiled-coil domain of unknown function PSK_trans_fac PF07704.11 ELR12218.1 - 0.033 15.0 3.0 0.092 13.5 3.0 1.7 1 1 0 1 1 1 0 Rv0623-like transcription factor NYD-SP28_assoc PF14775.6 ELR12218.1 - 0.043 13.9 1.4 0.075 13.1 1.4 1.4 1 0 0 1 1 1 0 Sperm tail C-terminal domain Herpes_BLRF2 PF05812.12 ELR12218.1 - 0.17 12.0 3.1 0.35 11.0 0.1 2.5 3 0 0 3 3 3 0 Herpesvirus BLRF2 protein CorA PF01544.18 ELR12218.1 - 0.19 11.0 0.2 0.32 10.3 0.2 1.2 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein Takusan PF04822.13 ELR12218.1 - 0.25 11.3 0.1 0.25 11.3 0.1 1.6 2 0 0 2 2 2 0 Takusan PikAIV_N PF18605.1 ELR12218.1 - 0.71 9.5 8.5 0.089 12.4 3.7 2.0 2 0 0 2 2 2 0 Narbonolide/10-deoxymethynolide synthase PikA4 N-terminal domain Gtr1_RagA PF04670.12 ELR12219.1 - 5.1e-73 245.2 1.3 5.1e-73 245.2 1.3 1.5 2 0 0 2 2 2 1 Gtr1/RagA G protein conserved region Arf PF00025.21 ELR12219.1 - 1.7e-05 24.3 0.0 2.7e-05 23.7 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 ELR12219.1 - 6.1e-05 23.2 0.0 0.00011 22.4 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 ELR12219.1 - 0.00016 21.7 0.0 0.0005 20.1 0.0 1.9 2 0 0 2 2 2 1 50S ribosome-binding GTPase SRPRB PF09439.10 ELR12219.1 - 0.00075 19.0 0.0 0.0013 18.2 0.0 1.3 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Ras PF00071.22 ELR12219.1 - 0.0011 18.6 0.0 0.0016 18.0 0.0 1.2 1 0 0 1 1 1 1 Ras family AAA_16 PF13191.6 ELR12219.1 - 0.0037 17.7 0.1 0.037 14.4 0.0 2.4 2 1 1 3 3 3 1 AAA ATPase domain AAA_14 PF13173.6 ELR12219.1 - 0.072 13.1 0.0 0.18 11.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain Epimerase PF01370.21 ELR12221.1 - 0.00047 19.7 0.1 0.0049 16.4 0.0 2.0 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family DUF2817 PF10994.8 ELR12221.1 - 0.13 11.7 0.0 0.2 11.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2817) TRAM_LAG1_CLN8 PF03798.16 ELR12223.1 - 8.3e-19 68.1 19.3 8.3e-19 68.1 19.3 2.5 2 1 0 2 2 2 1 TLC domain Pmp3 PF01679.17 ELR12223.1 - 5.7 7.2 11.4 2.5 8.4 0.2 3.2 3 0 0 3 3 3 0 Proteolipid membrane potential modulator LRR19-TM PF15176.6 ELR12224.1 - 0.049 13.6 0.9 0.053 13.5 0.9 1.3 1 1 0 1 1 1 0 Leucine-rich repeat family 19 TM domain p450 PF00067.22 ELR12225.1 - 5.1e-40 137.6 0.2 7.3e-40 137.1 0.2 1.1 1 0 0 1 1 1 1 Cytochrome P450 PutA_N PF18083.1 ELR12225.1 - 0.13 12.3 0.1 2.5 8.1 0.0 2.3 2 0 0 2 2 2 0 Proline utilization A N-terminal domain Hydantoinase_A PF01968.18 ELR12225.1 - 0.17 11.1 0.1 0.26 10.5 0.1 1.4 1 0 0 1 1 1 0 Hydantoinase/oxoprolinase IBR PF01485.21 ELR12226.1 - 3.4e-07 30.4 1.4 3.4e-07 30.4 1.4 7.0 7 0 0 7 7 7 1 IBR domain, a half RING-finger domain zf-RING_2 PF13639.6 ELR12226.1 - 7e-07 29.5 2.1 7e-07 29.5 2.1 6.2 5 2 0 5 5 5 2 Ring finger domain zf-RING_UBOX PF13445.6 ELR12226.1 - 0.0004 20.3 0.4 0.0004 20.3 0.4 5.7 5 0 0 5 5 5 2 RING-type zinc-finger zf-RING_11 PF17123.5 ELR12226.1 - 0.0017 18.0 1.4 0.0017 18.0 1.4 3.6 4 0 0 4 4 4 1 RING-like zinc finger zf-RING_5 PF14634.6 ELR12226.1 - 0.0026 17.7 0.2 0.0026 17.7 0.2 6.7 4 3 1 5 5 5 2 zinc-RING finger domain zf-C3HC4_2 PF13923.6 ELR12226.1 - 0.0038 17.0 0.3 0.0038 17.0 0.3 7.4 9 0 0 9 9 9 2 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 ELR12226.1 - 0.012 15.9 5.2 0.012 15.9 5.2 4.6 3 1 1 4 4 4 0 RING-H2 zinc finger domain Vps39_2 PF10367.9 ELR12226.1 - 0.058 13.8 0.3 0.058 13.8 0.3 5.1 6 1 0 6 6 6 0 Vacuolar sorting protein 39 domain 2 zf-tcix PF14952.6 ELR12226.1 - 0.1 12.2 5.9 24 4.7 0.0 3.3 2 0 0 2 2 2 0 Putative treble-clef, zinc-finger, Zn-binding FlgH PF02107.16 ELR12226.1 - 1.5 8.4 6.8 0.057 13.0 0.3 1.9 2 0 0 2 2 2 0 Flagellar L-ring protein F-box-like PF12937.7 ELR12227.1 - 2e-05 24.4 0.7 5.8e-05 22.9 0.7 1.8 1 0 0 1 1 1 1 F-box-like SPRY PF00622.28 ELR12227.1 - 0.00043 20.4 0.1 0.00086 19.4 0.1 1.6 1 1 0 1 1 1 1 SPRY domain DUF4423 PF14394.6 ELR12227.1 - 0.21 11.3 0.0 0.32 10.7 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4423) F-box PF00646.33 ELR12227.1 - 0.28 11.1 1.3 0.56 10.1 0.1 2.0 2 0 0 2 2 2 0 F-box domain DUF2205 PF10224.9 ELR12228.1 - 0.13 12.2 0.2 4 7.5 0.0 2.4 2 0 0 2 2 2 0 Short coiled-coil protein IL31 PF15209.6 ELR12228.1 - 1 9.1 5.5 1.8 8.3 0.5 3.0 3 0 0 3 3 3 0 Interleukin 31 FAM24 PF15193.6 ELR12228.1 - 4.1 8.2 7.2 1.8 9.4 0.8 3.1 2 1 0 3 3 3 0 FAM24 family RhoGAP PF00620.27 ELR12229.1 - 2.9e-20 72.6 0.0 1.4e-19 70.5 0.0 2.0 1 1 0 1 1 1 1 RhoGAP domain MyTH4 PF00784.17 ELR12229.1 - 1.7e-19 70.3 0.2 4.2e-19 69.0 0.0 1.7 2 0 0 2 2 2 1 MyTH4 domain COX_ARM PF06481.14 ELR12229.1 - 0.0039 17.1 0.0 0.01 15.7 0.0 1.8 2 0 0 2 2 2 1 COX Aromatic Rich Motif DUF4051 PF13260.6 ELR12231.1 - 0.043 13.5 0.0 0.061 13.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4051) F-box PF00646.33 ELR12235.1 - 0.00028 20.7 0.9 0.00028 20.7 0.9 1.7 2 0 0 2 2 2 1 F-box domain Ank_4 PF13637.6 ELR12235.1 - 0.006 17.1 0.1 1.2 9.8 0.0 2.5 2 0 0 2 2 2 2 Ankyrin repeats (many copies) DUF547 PF04784.14 ELR12236.1 - 2.3e-11 43.8 0.0 5.1e-10 39.5 0.0 2.5 2 1 0 2 2 2 1 Protein of unknown function, DUF547 eRF1_1 PF03463.15 ELR12238.1 - 3.5e-07 30.3 0.0 4e-07 30.1 0.0 1.1 1 0 0 1 1 1 1 eRF1 domain 1 MtrF PF09472.10 ELR12238.1 - 0.18 11.2 0.7 9.6 5.7 0.1 2.4 1 1 1 2 2 2 0 Tetrahydromethanopterin S-methyltransferase, F subunit (MtrF) FtsX PF02687.21 ELR12239.1 - 3.6e-09 37.0 7.0 3.6e-09 37.0 7.0 4.8 4 1 1 5 5 5 1 FtsX-like permease family DUF2615 PF11027.8 ELR12239.1 - 9.4 6.4 6.6 8.7 6.5 0.4 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF2615) DUF3605 PF12239.8 ELR12240.1 - 1.1e-14 55.1 0.1 3e-13 50.4 0.1 2.0 1 1 0 1 1 1 1 Protein of unknown function (DUF3605) ABC2_membrane PF01061.24 ELR12242.1 - 1.1e-78 263.5 46.2 7.8e-40 136.5 16.1 3.4 2 1 1 3 3 3 3 ABC-2 type transporter ABC_tran PF00005.27 ELR12242.1 - 7.7e-44 149.5 0.0 8.5e-21 74.9 0.0 2.5 2 0 0 2 2 2 2 ABC transporter AAA_16 PF13191.6 ELR12242.1 - 7.5e-10 39.4 0.2 0.00022 21.6 0.0 2.6 2 0 0 2 2 2 2 AAA ATPase domain RsgA_GTPase PF03193.16 ELR12242.1 - 2.3e-07 30.9 0.1 0.0025 17.7 0.1 2.4 2 0 0 2 2 2 2 RsgA GTPase PDR_CDR PF06422.12 ELR12242.1 - 1.4e-06 28.1 5.0 0.018 15.0 0.0 4.0 5 0 0 5 5 5 2 CDR ABC transporter AAA_29 PF13555.6 ELR12242.1 - 1.4e-06 27.9 0.3 0.0067 16.2 0.1 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_22 PF13401.6 ELR12242.1 - 2.2e-06 28.0 0.1 0.041 14.2 0.0 3.3 3 1 0 3 3 2 2 AAA domain AAA_21 PF13304.6 ELR12242.1 - 5.4e-06 26.4 0.0 0.54 10.0 0.0 4.1 4 0 0 4 4 4 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_25 PF13481.6 ELR12242.1 - 3.6e-05 23.4 0.3 0.27 10.8 0.1 2.5 2 0 0 2 2 2 2 AAA domain AAA_18 PF13238.6 ELR12242.1 - 4.5e-05 24.0 0.1 0.13 12.9 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_28 PF13521.6 ELR12242.1 - 7.6e-05 23.0 0.4 0.22 11.8 0.0 2.5 2 0 0 2 2 2 2 AAA domain RNA_helicase PF00910.22 ELR12242.1 - 0.00027 21.3 0.1 0.75 10.2 0.0 2.7 2 0 0 2 2 2 2 RNA helicase MMR_HSR1 PF01926.23 ELR12242.1 - 0.00028 20.9 0.6 0.99 9.5 0.0 2.7 2 0 0 2 2 2 2 50S ribosome-binding GTPase NACHT PF05729.12 ELR12242.1 - 0.00039 20.4 1.1 0.068 13.1 0.0 2.5 2 0 0 2 2 2 1 NACHT domain Zeta_toxin PF06414.12 ELR12242.1 - 0.00039 19.8 0.3 0.17 11.2 0.0 2.4 2 0 0 2 2 2 1 Zeta toxin Rad17 PF03215.15 ELR12242.1 - 0.0004 20.4 0.0 1.1 9.1 0.0 2.5 2 0 0 2 2 2 2 Rad17 P-loop domain AAA PF00004.29 ELR12242.1 - 0.0018 18.7 0.5 0.15 12.5 0.0 3.1 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_33 PF13671.6 ELR12242.1 - 0.0021 18.2 1.0 1.2 9.3 0.0 2.8 3 0 0 3 3 2 1 AAA domain AAA_30 PF13604.6 ELR12242.1 - 0.0023 17.7 0.4 2.1 8.0 0.1 2.4 2 0 0 2 2 2 2 AAA domain AAA_5 PF07728.14 ELR12242.1 - 0.0048 16.9 1.0 0.57 10.2 0.2 2.6 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) Viral_helicase1 PF01443.18 ELR12242.1 - 0.0063 16.3 0.4 0.03 14.1 0.0 2.2 2 0 0 2 2 2 1 Viral (Superfamily 1) RNA helicase DUF815 PF05673.13 ELR12242.1 - 0.0087 15.2 0.1 0.57 9.3 0.0 2.4 2 0 0 2 2 2 1 Protein of unknown function (DUF815) DUF87 PF01935.17 ELR12242.1 - 0.013 15.6 2.4 0.6 10.2 0.3 2.5 2 0 0 2 2 2 0 Helicase HerA, central domain MeaB PF03308.16 ELR12242.1 - 0.025 13.6 0.2 1.5 7.7 0.0 2.3 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Ploopntkinase3 PF18751.1 ELR12242.1 - 0.031 14.2 0.3 7 6.5 0.1 2.5 2 0 0 2 2 2 0 P-loop Nucleotide Kinase3 ATPase_2 PF01637.18 ELR12242.1 - 0.07 13.0 0.0 1 9.2 0.0 2.3 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea AAA_23 PF13476.6 ELR12242.1 - 0.086 13.3 0.0 13 6.2 0.0 2.4 2 0 0 2 2 2 0 AAA domain TsaE PF02367.17 ELR12242.1 - 0.16 12.0 0.5 13 5.8 0.3 2.5 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE cobW PF02492.19 ELR12242.1 - 0.16 11.5 0.9 3 7.4 0.1 2.3 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain SPC25 PF06703.11 ELR12242.1 - 0.17 11.6 2.2 3.6 7.4 0.4 2.8 3 0 0 3 3 2 0 Microsomal signal peptidase 25 kDa subunit (SPC25) AAA_24 PF13479.6 ELR12242.1 - 0.29 10.8 0.8 11 5.7 0.2 2.4 2 0 0 2 2 2 0 AAA domain DUF3810 PF12725.7 ELR12242.1 - 0.35 10.2 0.0 0.35 10.2 0.0 3.4 4 0 0 4 4 3 0 Protein of unknown function (DUF3810) SelP_N PF04592.14 ELR12242.1 - 10 5.5 8.4 21 4.4 8.4 1.4 1 0 0 1 1 1 0 Selenoprotein P, N terminal region DUF2052 PF09747.9 ELR12244.1 - 0.041 14.0 17.8 0.079 13.1 9.7 2.3 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) CPSF100_C PF13299.6 ELR12244.1 - 0.093 12.9 15.3 0.8 9.9 2.6 2.3 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal DDHD PF02862.17 ELR12244.1 - 0.47 10.6 6.2 5.2 7.2 0.2 2.3 2 0 0 2 2 2 0 DDHD domain DUF4337 PF14235.6 ELR12244.1 - 0.82 9.8 9.5 1.1 9.3 0.6 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4337) BORG_CEP PF14957.6 ELR12244.1 - 3 9.0 6.3 16 6.7 0.9 2.7 2 0 0 2 2 2 0 Cdc42 effector Vfa1 PF08432.10 ELR12244.1 - 7.7 6.8 18.0 7.4 6.9 5.3 2.4 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 DUF5427 PF10310.9 ELR12244.1 - 7.8 5.3 19.8 4.2 6.2 7.7 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF5427) ABC2_membrane PF01061.24 ELR12245.1 - 3.6e-88 294.5 45.5 8.3e-46 156.0 20.7 2.4 2 0 0 2 2 2 2 ABC-2 type transporter ABC_tran PF00005.27 ELR12245.1 - 2.1e-44 151.4 0.0 2.2e-21 76.8 0.0 2.5 2 0 0 2 2 2 2 ABC transporter AAA_16 PF13191.6 ELR12245.1 - 1.2e-09 38.8 0.5 0.00032 21.1 0.0 2.8 3 0 0 3 3 2 2 AAA ATPase domain RsgA_GTPase PF03193.16 ELR12245.1 - 1.6e-07 31.4 0.1 0.0027 17.6 0.1 2.4 2 0 0 2 2 2 2 RsgA GTPase ABC2_membrane_3 PF12698.7 ELR12245.1 - 3.8e-07 29.6 2.1 3.8e-07 29.6 2.1 3.1 2 1 0 3 3 3 1 ABC-2 family transporter protein AAA_29 PF13555.6 ELR12245.1 - 5.6e-07 29.2 0.3 0.0067 16.1 0.1 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_22 PF13401.6 ELR12245.1 - 2e-06 28.1 0.1 0.036 14.3 0.0 3.3 2 1 0 2 2 2 2 AAA domain AAA_21 PF13304.6 ELR12245.1 - 2.8e-06 27.4 0.0 0.64 9.8 0.0 4.1 4 0 0 4 4 4 1 AAA domain, putative AbiEii toxin, Type IV TA system PDR_CDR PF06422.12 ELR12245.1 - 2.8e-05 23.9 9.2 0.015 15.2 0.0 4.0 5 0 0 5 5 3 2 CDR ABC transporter AAA_25 PF13481.6 ELR12245.1 - 3.3e-05 23.6 0.3 0.25 10.9 0.1 2.5 2 0 0 2 2 2 2 AAA domain AAA_28 PF13521.6 ELR12245.1 - 3.4e-05 24.2 0.4 0.099 12.9 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_18 PF13238.6 ELR12245.1 - 3.6e-05 24.3 0.1 0.099 13.2 0.0 2.6 2 0 0 2 2 2 2 AAA domain Rad17 PF03215.15 ELR12245.1 - 0.00019 21.4 0.0 0.48 10.3 0.0 2.4 2 0 0 2 2 2 2 Rad17 P-loop domain RNA_helicase PF00910.22 ELR12245.1 - 0.00024 21.5 0.1 0.64 10.4 0.0 2.7 2 0 0 2 2 2 2 RNA helicase MMR_HSR1 PF01926.23 ELR12245.1 - 0.00028 20.9 1.4 0.6 10.2 0.0 2.8 3 0 0 3 3 2 2 50S ribosome-binding GTPase NACHT PF05729.12 ELR12245.1 - 0.00028 20.8 1.1 0.055 13.4 0.0 2.6 2 0 0 2 2 2 1 NACHT domain Zeta_toxin PF06414.12 ELR12245.1 - 0.00034 19.9 0.3 0.16 11.2 0.0 2.5 2 0 0 2 2 2 1 Zeta toxin AAA PF00004.29 ELR12245.1 - 0.0018 18.7 0.5 0.17 12.3 0.0 3.1 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_30 PF13604.6 ELR12245.1 - 0.0019 18.0 0.6 1.9 8.2 0.1 2.4 2 0 0 2 2 2 2 AAA domain AAA_33 PF13671.6 ELR12245.1 - 0.0026 18.0 1.0 1.2 9.3 0.0 2.7 3 0 0 3 3 2 1 AAA domain AAA_5 PF07728.14 ELR12245.1 - 0.003 17.6 1.0 0.37 10.8 0.2 2.6 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) DUF815 PF05673.13 ELR12245.1 - 0.0062 15.7 0.1 0.41 9.8 0.0 2.4 2 0 0 2 2 2 1 Protein of unknown function (DUF815) CLLAC PF15675.5 ELR12245.1 - 0.0065 16.0 1.6 0.019 14.5 1.6 1.8 1 0 0 1 1 1 1 CLLAC-motif containing domain AAA_23 PF13476.6 ELR12245.1 - 0.0083 16.7 0.1 4.4 7.8 0.0 2.5 2 0 0 2 2 2 1 AAA domain Viral_helicase1 PF01443.18 ELR12245.1 - 0.0098 15.7 0.4 0.048 13.4 0.0 2.2 2 0 0 2 2 2 1 Viral (Superfamily 1) RNA helicase DUF87 PF01935.17 ELR12245.1 - 0.014 15.5 3.0 0.6 10.2 0.4 2.4 2 0 0 2 2 2 0 Helicase HerA, central domain Ploopntkinase3 PF18751.1 ELR12245.1 - 0.02 14.8 0.3 6.9 6.5 0.1 2.5 2 0 0 2 2 2 0 P-loop Nucleotide Kinase3 MeaB PF03308.16 ELR12245.1 - 0.027 13.4 0.2 1.4 7.8 0.0 2.3 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB ATPase_2 PF01637.18 ELR12245.1 - 0.036 14.0 0.0 0.64 9.9 0.0 2.4 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea Zip PF02535.22 ELR12245.1 - 0.1 11.8 0.2 0.51 9.5 0.2 2.2 1 0 0 1 1 1 0 ZIP Zinc transporter TsaE PF02367.17 ELR12245.1 - 0.11 12.5 0.5 14 5.7 0.3 2.6 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE cobW PF02492.19 ELR12245.1 - 0.12 12.0 0.9 2.9 7.4 0.1 2.4 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_14 PF13173.6 ELR12245.1 - 0.15 12.1 0.1 11 6.0 0.0 2.8 3 0 0 3 3 2 0 AAA domain APS_kinase PF01583.20 ELR12245.1 - 0.17 11.8 0.1 3.2 7.6 0.0 2.3 2 0 0 2 2 2 0 Adenylylsulphate kinase AAA_24 PF13479.6 ELR12245.1 - 0.18 11.5 0.9 11 5.7 0.2 2.4 2 0 0 2 2 2 0 AAA domain DUF3810 PF12725.7 ELR12245.1 - 0.26 10.6 9.2 0.32 10.3 0.0 3.5 3 0 0 3 3 3 0 Protein of unknown function (DUF3810) C2 PF00168.30 ELR12246.1 - 2.1e-37 127.5 0.0 5e-24 84.6 0.0 2.4 2 0 0 2 2 2 2 C2 domain Peptidase_C92 PF05708.12 ELR12246.1 - 2e-06 28.0 0.0 7.2e-06 26.2 0.0 1.7 1 1 0 1 1 1 1 Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family NLPC_P60 PF00877.19 ELR12246.1 - 0.053 13.6 0.0 1 9.4 0.0 2.5 2 1 0 2 2 2 0 NlpC/P60 family Pkinase_Tyr PF07714.17 ELR12247.1 - 1.7e-60 204.5 0.0 2.5e-60 203.9 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ELR12247.1 - 6.1e-58 196.3 0.0 8.5e-58 195.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.23 ELR12247.1 - 0.0024 17.9 0.0 0.0057 16.6 0.0 1.7 1 0 0 1 1 1 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 ELR12247.1 - 0.036 13.0 0.1 0.084 11.8 0.1 1.5 1 1 0 1 1 1 0 Haspin like kinase domain Pkinase_fungal PF17667.1 ELR12247.1 - 0.041 12.7 0.0 0.49 9.1 0.0 2.0 2 0 0 2 2 2 0 Fungal protein kinase Ceramidase PF05875.12 ELR12248.1 - 4.5e-07 29.6 10.3 1.1e-06 28.3 9.8 1.7 1 1 1 2 2 2 2 Ceramidase 7TM-7TMR_HD PF07698.11 ELR12248.1 - 0.018 14.8 2.6 0.78 9.5 0.6 2.2 1 1 1 2 2 2 0 7TM receptor with intracellular HD hydrolase DUF1056 PF06341.11 ELR12248.1 - 0.23 11.8 6.8 0.28 11.5 0.1 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF1056) MreD PF04093.12 ELR12248.1 - 0.25 11.4 7.3 0.69 10.0 7.1 1.9 1 1 1 2 2 2 0 rod shape-determining protein MreD NMN_transporter PF04973.12 ELR12248.1 - 0.47 10.4 6.0 0.93 9.4 6.0 1.5 1 1 0 1 1 1 0 Nicotinamide mononucleotide transporter Comm PF15957.5 ELR12248.1 - 5.6 7.3 7.5 27 5.1 0.0 2.6 2 1 0 3 3 3 0 Commissureless FAD_binding_3 PF01494.19 ELR12249.1 - 3.5e-06 26.5 0.0 3.8e-06 26.4 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 ELR12249.1 - 1.4e-05 24.5 0.2 1.5e-05 24.4 0.2 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 ELR12249.1 - 1.6e-05 24.3 0.1 2e-05 24.0 0.1 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 ELR12249.1 - 0.0015 17.3 0.1 0.0019 17.0 0.1 1.1 1 0 0 1 1 1 1 HI0933-like protein NAD_binding_8 PF13450.6 ELR12249.1 - 0.0031 17.7 0.1 0.0031 17.7 0.1 1.5 2 0 0 2 2 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 ELR12249.1 - 0.0066 15.6 0.7 0.0067 15.6 0.7 1.1 1 0 0 1 1 1 1 FAD binding domain Thi4 PF01946.17 ELR12249.1 - 0.0075 15.5 0.0 0.0097 15.2 0.0 1.3 1 0 0 1 1 1 1 Thi4 family Lycopene_cycl PF05834.12 ELR12249.1 - 0.029 13.4 0.3 0.029 13.4 0.3 1.1 1 0 0 1 1 1 0 Lycopene cyclase protein AlaDh_PNT_C PF01262.21 ELR12249.1 - 0.056 12.7 0.3 0.061 12.6 0.3 1.2 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Pyr_redox PF00070.27 ELR12249.1 - 0.063 13.8 0.0 0.075 13.6 0.0 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase IlvN PF07991.12 ELR12249.1 - 0.12 11.9 0.1 0.17 11.5 0.0 1.4 1 1 0 1 1 1 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain 2-Hacid_dh_C PF02826.19 ELR12249.1 - 0.17 11.2 0.0 0.18 11.2 0.0 1.1 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Kinesin PF00225.23 ELR12253.1 - 6.2e-83 278.5 0.3 6.2e-83 278.5 0.3 2.2 2 1 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 ELR12253.1 - 1.5e-22 80.1 0.7 4.7e-22 78.5 0.1 2.1 2 0 0 2 2 2 1 Microtubule binding Borrelia_P83 PF05262.11 ELR12253.1 - 0.00016 20.3 0.0 0.00016 20.3 0.0 2.7 1 1 1 2 2 2 1 Borrelia P83/100 protein SlyX PF04102.12 ELR12253.1 - 0.024 15.3 3.0 2.1 9.0 0.4 3.4 2 0 0 2 2 2 0 SlyX TolA_bind_tri PF16331.5 ELR12253.1 - 0.88 9.7 6.8 1.4 9.1 0.1 3.1 3 0 0 3 3 3 0 TolA binding protein trimerisation F-box-like PF12937.7 ELR12254.1 - 2.6e-07 30.4 1.0 4.6e-07 29.6 0.2 1.9 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 ELR12254.1 - 0.0001 22.1 0.4 0.00023 21.0 0.0 1.8 2 0 0 2 2 2 1 F-box domain F-box_5 PF18511.1 ELR12254.1 - 0.00019 21.0 0.3 0.00052 19.5 0.0 1.9 2 0 0 2 2 2 1 F-box TMEM144 PF07857.12 ELR12254.1 - 0.014 14.4 0.1 0.031 13.3 0.1 1.5 2 0 0 2 2 2 0 Transmembrane family, TMEM144 of transporters SH3_9 PF14604.6 ELR12254.1 - 0.069 13.0 0.0 0.13 12.1 0.0 1.4 1 0 0 1 1 1 0 Variant SH3 domain TMEM234 PF10639.9 ELR12255.1 - 1.2e-35 122.1 1.3 1.5e-35 121.7 1.3 1.2 1 0 0 1 1 1 1 Putative transmembrane family 234 zf-LITAF-like PF10601.9 ELR12255.1 - 0.36 11.1 1.9 3.7 7.9 0.1 2.5 1 1 1 2 2 2 0 LITAF-like zinc ribbon domain WD40 PF00400.32 ELR12256.1 - 3.9e-27 93.9 23.4 0.00011 22.9 0.2 7.3 7 1 0 7 7 7 5 WD domain, G-beta repeat F-box-like PF12937.7 ELR12256.1 - 1.6e-12 47.1 0.4 4.3e-12 45.7 0.4 1.8 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ELR12256.1 - 1.2e-06 28.3 0.1 2.8e-06 27.0 0.1 1.6 1 0 0 1 1 1 1 F-box domain Nup160 PF11715.8 ELR12256.1 - 2.7e-06 26.4 4.4 0.17 10.5 0.1 4.0 3 1 1 4 4 4 3 Nucleoporin Nup120/160 WD40_like PF17005.5 ELR12256.1 - 0.0023 17.3 0.0 0.58 9.4 0.0 2.9 1 1 2 3 3 3 1 WD40-like domain PQQ_3 PF13570.6 ELR12256.1 - 0.0079 16.7 0.0 6.2 7.4 0.0 4.2 3 0 0 3 3 3 1 PQQ-like domain F-box_4 PF15966.5 ELR12256.1 - 0.0094 15.8 0.2 0.033 14.1 0.0 2.0 2 0 0 2 2 2 1 F-box PCSK9_C2 PF18464.1 ELR12256.1 - 0.024 14.6 0.4 2.4 8.3 0.0 2.7 2 0 0 2 2 2 0 Proprotein convertase subtilisin-like/kexin type 9 C-terminal domain RRM_1 PF00076.22 ELR12257.1 - 3.1e-21 75.0 0.0 4.6e-21 74.4 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 ELR12257.1 - 0.051 13.7 0.1 0.15 12.2 0.1 1.7 1 1 0 1 1 1 0 RNA recognition motif OB_RNB PF08206.11 ELR12257.1 - 0.16 11.7 1.9 0.33 10.7 0.0 2.5 2 0 0 2 2 2 0 Ribonuclease B OB domain CUE PF02845.16 ELR12258.1 - 3.6e-12 45.7 0.4 5.2e-07 29.3 0.2 2.3 2 0 0 2 2 2 2 CUE domain FHA_2 PF17913.1 ELR12258.1 - 0.00012 22.3 0.0 0.00025 21.2 0.0 1.5 1 0 0 1 1 1 1 FHA domain UBA PF00627.31 ELR12258.1 - 0.00017 21.4 0.8 0.2 11.6 0.1 2.7 2 0 0 2 2 2 2 UBA/TS-N domain DUF1296 PF06972.11 ELR12258.1 - 0.00023 21.2 0.4 0.31 11.2 0.1 2.4 2 0 0 2 2 2 2 Protein of unknown function (DUF1296) FHA PF00498.26 ELR12258.1 - 0.0095 16.3 0.0 0.016 15.5 0.0 1.4 1 0 0 1 1 1 1 FHA domain UBA_4 PF14555.6 ELR12258.1 - 0.023 14.5 0.1 0.2 11.5 0.0 2.2 2 0 0 2 2 2 0 UBA-like domain DMA PF03474.14 ELR12258.1 - 0.049 13.2 1.2 0.66 9.6 0.0 2.4 2 0 0 2 2 2 0 DMRTA motif HBS1_N PF08938.10 ELR12258.1 - 0.1 12.9 0.0 0.1 12.9 0.0 3.3 3 0 0 3 3 3 0 HBS1 N-terminus HEV_ORF1 PF02444.16 ELR12258.1 - 0.15 12.6 4.0 6.5 7.4 0.6 2.4 2 0 0 2 2 2 0 Hepatitis E virus ORF-2 (Putative capsid protein) Borrelia_P83 PF05262.11 ELR12258.1 - 1.1 7.6 7.2 1.7 7.1 7.2 1.3 1 0 0 1 1 1 0 Borrelia P83/100 protein YwhD PF08741.10 ELR12259.1 - 0.042 13.5 0.0 0.051 13.3 0.0 1.1 1 0 0 1 1 1 0 YwhD family Cob_adeno_trans PF01923.18 ELR12260.1 - 5e-56 189.4 0.0 5.8e-56 189.1 0.0 1.0 1 0 0 1 1 1 1 Cobalamin adenosyltransferase Lactamase_B_3 PF13483.6 ELR12261.1 - 0.01 15.7 0.0 0.029 14.3 0.0 1.7 1 0 0 1 1 1 0 Beta-lactamase superfamily domain Methyltransf_11 PF08241.12 ELR12261.1 - 0.079 13.6 0.0 0.32 11.7 0.0 2.0 1 0 0 1 1 1 0 Methyltransferase domain FAD_binding_4 PF01565.23 ELR12262.1 - 1.8e-11 43.9 0.6 4.1e-08 33.0 0.1 2.3 1 1 1 2 2 2 2 FAD binding domain ALO PF04030.14 ELR12262.1 - 0.0064 16.3 0.5 0.01 15.7 0.5 1.4 1 0 0 1 1 1 1 D-arabinono-1,4-lactone oxidase DUF5337 PF17272.2 ELR12262.1 - 0.018 14.9 0.1 0.075 12.9 0.0 2.0 2 0 0 2 2 2 0 Family of unknown function (DUF5337) PAP_central PF04928.17 ELR12264.1 - 0.0033 16.5 0.4 0.004 16.2 0.4 1.1 1 0 0 1 1 1 1 Poly(A) polymerase central domain Peroxidase_ext PF11895.8 ELR12264.1 - 0.062 13.2 0.0 0.1 12.5 0.0 1.4 1 0 0 1 1 1 0 Fungal peroxidase extension region DUF1993 PF09351.10 ELR12264.1 - 0.1 12.7 0.6 0.12 12.5 0.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1993) FMN_red PF03358.15 ELR12267.1 - 2e-37 128.3 0.0 2.5e-37 128.0 0.0 1.1 1 0 0 1 1 1 1 NADPH-dependent FMN reductase Flavodoxin_2 PF02525.17 ELR12267.1 - 8.8e-08 32.1 0.0 1.2e-07 31.6 0.0 1.2 1 0 0 1 1 1 1 Flavodoxin-like fold CLU PF13236.6 ELR12268.1 - 7.7e-35 120.7 0.0 1.3e-34 120.0 0.0 1.3 1 0 0 1 1 1 1 Clustered mitochondria eIF3_p135 PF12807.7 ELR12268.1 - 0.0034 17.4 1.6 0.0093 16.0 1.1 1.9 1 1 1 2 2 2 1 Translation initiation factor eIF3 subunit 135 Abhydrolase_1 PF00561.20 ELR12269.1 - 6.5e-15 55.5 0.2 3.5e-12 46.5 0.1 2.1 2 0 0 2 2 2 2 alpha/beta hydrolase fold Abhydro_lipase PF04083.16 ELR12269.1 - 4.7e-14 51.7 0.1 9.8e-14 50.7 0.1 1.6 1 0 0 1 1 1 1 Partial alpha/beta-hydrolase lipase region Hydrolase_4 PF12146.8 ELR12269.1 - 5e-07 29.2 0.0 9.4e-05 21.8 0.0 2.2 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Ldl_recept_b PF00058.17 ELR12270.1 - 0.004 17.6 0.3 0.057 13.9 0.3 3.2 1 0 0 1 1 1 1 Low-density lipoprotein receptor repeat class B F-box-like PF12937.7 ELR12271.1 - 1.2e-11 44.3 2.9 1.5e-11 44.0 0.1 2.4 3 0 0 3 3 3 1 F-box-like F-box PF00646.33 ELR12271.1 - 6.8e-08 32.2 1.1 7.9e-07 28.8 0.1 2.8 2 0 0 2 2 2 1 F-box domain LRR_4 PF12799.7 ELR12271.1 - 0.0021 18.4 11.5 0.29 11.6 0.6 6.3 4 4 2 6 6 6 2 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 ELR12271.1 - 1.9 9.4 3.9 36 5.5 0.1 4.1 4 0 0 4 4 4 0 Leucine Rich Repeat Asp_Arg_Hydrox PF05118.15 ELR12272.1 - 6.1e-51 172.4 0.1 7.7e-51 172.0 0.1 1.1 1 0 0 1 1 1 1 Aspartyl/Asparaginyl beta-hydroxylase WH2 PF02205.20 ELR12273.1 - 1.5e-06 27.8 4.9 0.034 14.0 0.1 4.3 5 0 0 5 5 5 2 WH2 motif CsbD PF05532.12 ELR12273.1 - 5.1e-05 23.1 4.0 0.00021 21.1 0.2 2.6 2 0 0 2 2 2 1 CsbD-like DUF3552 PF12072.8 ELR12273.1 - 0.018 14.5 5.8 0.042 13.3 5.8 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3552) YtxH PF12732.7 ELR12273.1 - 0.06 13.9 1.2 0.19 12.3 1.2 2.0 1 0 0 1 1 1 0 YtxH-like protein Kinesin PF00225.23 ELR12274.1 - 1.1e-103 346.7 0.0 1.1e-103 346.7 0.0 2.8 2 1 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 ELR12274.1 - 3.7e-26 91.8 0.0 3.7e-26 91.8 0.0 3.0 3 0 0 3 3 3 1 Microtubule binding HIP1_clath_bdg PF16515.5 ELR12274.1 - 0.0061 17.1 1.0 0.0061 17.1 1.0 15.7 5 4 8 15 15 15 4 Clathrin-binding domain of Huntingtin-interacting protein 1 DUF4993 PF16384.5 ELR12274.1 - 0.17 10.8 0.1 6 5.8 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function Med10 PF09748.9 ELR12275.1 - 4.4e-19 68.6 0.0 5.4e-19 68.3 0.0 1.0 1 0 0 1 1 1 1 Transcription factor subunit Med10 of Mediator complex Beta-lactamase PF00144.24 ELR12276.1 - 2.6e-37 128.8 0.2 5.2e-37 127.8 0.2 1.4 1 1 0 1 1 1 1 Beta-lactamase Peptidase_S11 PF00768.20 ELR12276.1 - 0.021 14.2 0.0 0.064 12.7 0.0 1.7 2 0 0 2 2 2 0 D-alanyl-D-alanine carboxypeptidase DUF1682 PF07946.14 ELR12277.1 - 0.0059 15.9 1.1 0.0087 15.3 1.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1682) Zn_clus PF00172.18 ELR12277.1 - 0.055 13.6 2.9 0.084 13.0 2.9 1.3 1 0 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain HAUS6_N PF14661.6 ELR12277.1 - 0.068 12.7 0.7 0.11 12.0 0.7 1.2 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus NUDE_C PF04880.13 ELR12277.1 - 0.081 13.4 0.5 0.081 13.4 0.5 2.7 3 0 0 3 3 3 0 NUDE protein, C-terminal conserved region PAS_9 PF13426.7 ELR12277.1 - 0.089 13.1 0.0 0.18 12.1 0.0 1.5 1 0 0 1 1 1 0 PAS domain DUF1515 PF07439.11 ELR12277.1 - 0.63 10.1 3.5 1.3 9.1 3.5 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1515) DUF724 PF05266.14 ELR12277.1 - 0.75 9.6 5.3 1.2 8.9 5.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF724) PspB PF06667.12 ELR12277.1 - 1.7 8.8 4.4 3.6 7.7 4.4 1.5 1 0 0 1 1 1 0 Phage shock protein B SHR-BD PF06650.12 ELR12278.1 - 1.1e-35 123.3 0.0 1.8e-35 122.6 0.0 1.3 1 0 0 1 1 1 1 SHR-binding domain of vacuolar-sorting associated protein 13 VPS13_C PF16909.5 ELR12278.1 - 5.1e-19 68.7 0.0 1.5e-18 67.2 0.0 1.7 2 0 0 2 2 2 1 Vacuolar-sorting-associated 13 protein C-terminal Apt1 PF10351.9 ELR12278.1 - 1.1e-11 44.3 0.0 4.1e-11 42.4 0.0 1.8 1 1 0 1 1 1 1 Golgi-body localisation protein domain DUF3446 PF11928.8 ELR12278.1 - 8.4 6.8 26.4 1.7 9.0 4.2 2.9 3 0 0 3 3 3 0 Early growth response N-terminal domain MLANA PF14991.6 ELR12279.1 - 0.14 12.5 0.2 2.3 8.5 0.1 2.2 2 0 0 2 2 2 0 Protein melan-A PGF-CTERM PF18204.1 ELR12280.1 - 0.13 12.2 0.4 0.13 12.2 0.4 3.0 3 0 0 3 3 3 0 PGF-CTERM motif DUF202 PF02656.15 ELR12280.1 - 0.17 12.3 7.5 1.4 9.4 1.8 2.9 2 1 0 2 2 2 0 Domain of unknown function (DUF202) p450 PF00067.22 ELR12281.1 - 6.3e-71 239.5 0.0 7.4e-71 239.3 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Csm1_N PF18504.1 ELR12282.1 - 0.00076 19.8 4.5 0.0026 18.1 3.8 2.1 1 1 1 2 2 2 1 Csm1 N-terminal domain DUF1645 PF07816.11 ELR12282.1 - 0.00093 19.8 2.9 0.00093 19.8 2.9 1.6 1 1 1 2 2 2 1 Protein of unknown function (DUF1645) TPD52 PF04201.15 ELR12282.1 - 0.0033 17.1 1.8 0.0051 16.4 1.8 1.3 1 0 0 1 1 1 1 Tumour protein D52 family GAS PF13851.6 ELR12282.1 - 0.0044 16.4 2.7 0.006 16.0 2.7 1.2 1 0 0 1 1 1 1 Growth-arrest specific micro-tubule binding APG6_N PF17675.1 ELR12282.1 - 0.0058 17.2 0.0 0.0074 16.8 0.0 1.2 1 0 0 1 1 1 1 Apg6 coiled-coil region YabA PF06156.13 ELR12282.1 - 0.012 16.2 0.5 0.02 15.5 0.5 1.3 1 0 0 1 1 1 0 Initiation control protein YabA MPS2 PF17060.5 ELR12282.1 - 0.028 13.7 0.2 0.037 13.3 0.2 1.1 1 0 0 1 1 1 0 Monopolar spindle protein 2 HAP1_N PF04849.13 ELR12282.1 - 0.038 13.2 3.5 0.054 12.7 3.5 1.2 1 0 0 1 1 1 0 HAP1 N-terminal conserved region UPF0242 PF06785.11 ELR12282.1 - 0.052 13.6 0.8 0.067 13.3 0.8 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus bZIP_1 PF00170.21 ELR12282.1 - 0.27 11.3 4.3 8.5 6.6 1.1 2.5 1 1 1 2 2 2 0 bZIP transcription factor SLX9 PF15341.6 ELR12282.1 - 2.3 8.6 6.1 4.6 7.7 0.3 2.2 2 0 0 2 2 2 0 Ribosome biogenesis protein SLX9 Myotub-related PF06602.14 ELR12283.1 - 7.4e-61 206.0 0.3 1.7e-60 204.9 0.3 1.6 1 1 0 1 1 1 1 Myotubularin-like phosphatase domain COR PF16095.5 ELR12283.1 - 1.1e-42 146.1 0.0 2.3e-42 145.0 0.0 1.6 1 0 0 1 1 1 1 C-terminal of Roc, COR, domain LRR_8 PF13855.6 ELR12283.1 - 1.2e-40 137.0 42.2 3.4e-10 39.5 3.5 6.6 3 3 2 6 6 6 6 Leucine rich repeat LRR_4 PF12799.7 ELR12283.1 - 1.2e-31 108.3 35.1 2.3e-05 24.6 1.9 8.1 4 3 4 9 9 9 9 Leucine Rich repeats (2 copies) Pkinase_Tyr PF07714.17 ELR12283.1 - 3e-21 75.9 0.0 8.8e-21 74.3 0.0 1.7 1 1 0 1 1 1 1 Protein tyrosine kinase Roc PF08477.13 ELR12283.1 - 3.4e-21 75.7 0.0 7.5e-16 58.4 0.0 3.1 2 1 0 3 3 3 2 Ras of Complex, Roc, domain of DAPkinase Pkinase PF00069.25 ELR12283.1 - 8e-21 74.6 0.0 1.8e-20 73.4 0.0 1.6 1 0 0 1 1 1 1 Protein kinase domain PH PF00169.29 ELR12283.1 - 9.5e-15 55.0 0.0 4.3e-14 52.9 0.0 2.3 1 0 0 1 1 1 1 PH domain LRR_9 PF14580.6 ELR12283.1 - 2.4e-09 36.9 7.3 5.7e-05 22.7 0.1 4.1 2 1 2 4 4 4 2 Leucine-rich repeat LRR_1 PF00560.33 ELR12283.1 - 2.2e-08 33.5 32.8 3.3 8.6 0.5 11.4 11 1 0 11 11 9 2 Leucine Rich Repeat PH_11 PF15413.6 ELR12283.1 - 1.3e-07 32.0 0.0 3.6e-07 30.6 0.0 1.8 1 0 0 1 1 1 1 Pleckstrin homology domain Ras PF00071.22 ELR12283.1 - 3.3e-06 26.8 0.0 0.00065 19.3 0.0 2.3 2 0 0 2 2 2 1 Ras family PH_9 PF15410.6 ELR12283.1 - 0.00075 19.9 0.0 0.0016 18.8 0.0 1.5 1 0 0 1 1 1 1 Pleckstrin homology domain LRR_6 PF13516.6 ELR12283.1 - 0.0032 17.4 33.0 5 7.4 0.6 10.7 11 0 0 11 11 11 2 Leucine Rich repeat PH_8 PF15409.6 ELR12283.1 - 0.0062 16.8 0.1 0.53 10.6 0.0 2.8 2 0 0 2 2 2 1 Pleckstrin homology domain MMR_HSR1 PF01926.23 ELR12283.1 - 0.0081 16.2 0.0 0.018 15.1 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase WD40 PF00400.32 ELR12283.1 - 0.015 16.2 0.0 0.068 14.1 0.0 2.3 1 0 0 1 1 1 0 WD domain, G-beta repeat Pkinase_Tyr PF07714.17 ELR12284.1 - 1.1e-19 70.7 0.1 1.7e-19 70.1 0.1 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ELR12284.1 - 1.2e-14 54.3 0.0 2e-14 53.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain BTB_2 PF02214.22 ELR12285.1 - 1.7e-16 60.3 0.0 3.6e-16 59.3 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain VWA_2 PF13519.6 ELR12287.1 - 2.6e-12 47.4 0.2 4.2e-12 46.7 0.2 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.28 ELR12287.1 - 1.6e-10 41.5 0.2 2e-10 41.2 0.2 1.1 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_3 PF13768.6 ELR12287.1 - 4.8e-10 39.6 0.2 9.8e-10 38.6 0.2 1.5 1 1 0 1 1 1 1 von Willebrand factor type A domain PP2 PF14299.6 ELR12287.1 - 0.043 13.9 0.0 0.045 13.8 0.0 1.3 1 0 0 1 1 1 0 Phloem protein 2 WD40 PF00400.32 ELR12290.1 - 1.8e-09 38.1 6.0 0.00077 20.2 0.0 5.1 5 0 0 5 5 5 2 WD domain, G-beta repeat AlgF PF11182.8 ELR12290.1 - 0.16 11.7 0.0 0.31 10.8 0.0 1.4 1 0 0 1 1 1 0 Alginate O-acetyl transferase AlgF DUF1218 PF06749.12 ELR12291.1 - 0.0006 20.3 2.4 0.001 19.5 1.6 1.8 1 1 1 2 2 2 1 Protein of unknown function (DUF1218) CitMHS PF03600.16 ELR12291.1 - 0.097 11.9 6.0 0.17 11.1 6.0 1.6 1 1 0 1 1 1 0 Citrate transporter Amastin PF07344.11 ELR12291.1 - 0.13 12.1 7.5 0.24 11.3 7.4 1.6 1 1 0 1 1 1 0 Amastin surface glycoprotein DUF996 PF06195.13 ELR12291.1 - 0.58 10.4 7.5 0.2 12.0 3.7 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF996) CBS PF00571.28 ELR12292.1 - 1e-27 96.3 0.4 1.7e-07 31.6 0.0 4.3 4 0 0 4 4 4 4 CBS domain CSTF_C PF14304.6 ELR12292.1 - 0.012 15.2 0.2 0.7 9.5 0.1 2.5 2 0 0 2 2 2 0 Transcription termination and cleavage factor C-terminal BCIP PF13862.6 ELR12292.1 - 0.15 11.8 0.0 0.24 11.1 0.0 1.3 1 0 0 1 1 1 0 p21-C-terminal region-binding protein ACT_7 PF13840.6 ELR12293.1 - 6.3e-25 86.8 0.0 1.9e-11 43.6 0.0 2.4 2 0 0 2 2 2 2 ACT domain Castor1_N PF18700.1 ELR12293.1 - 6.4e-11 41.9 0.8 2e-07 30.7 0.1 2.4 2 0 0 2 2 2 2 Cytosolic arginine sensor for mTORC1 subunit 1 N-terminal domain TPR_12 PF13424.6 ELR12294.1 - 0.0032 17.7 0.8 2.6 8.4 0.0 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat LRR_4 PF12799.7 ELR12295.1 - 2.5e-08 34.1 6.3 1.2 9.6 0.0 5.9 4 1 1 6 6 6 4 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 ELR12295.1 - 0.0013 19.0 7.8 39 5.4 0.4 6.3 6 1 0 6 6 6 2 Leucine Rich Repeat LRR_8 PF13855.6 ELR12295.1 - 9.5 6.1 10.1 26 4.7 0.8 4.2 4 2 0 4 4 4 0 Leucine rich repeat MMR_HSR1 PF01926.23 ELR12296.1 - 1.2e-07 31.8 0.0 3.5e-07 30.3 0.0 1.8 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_16 PF13191.6 ELR12296.1 - 0.00062 20.2 0.0 0.0014 19.0 0.0 1.7 1 0 0 1 1 1 1 AAA ATPase domain DUF815 PF05673.13 ELR12296.1 - 0.0015 17.7 0.0 0.0032 16.7 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF815) T2SSE PF00437.20 ELR12296.1 - 0.0019 17.3 0.2 0.0045 16.1 0.0 1.6 2 0 0 2 2 2 1 Type II/IV secretion system protein RsgA_GTPase PF03193.16 ELR12296.1 - 0.0023 17.9 0.0 0.0049 16.8 0.0 1.5 1 0 0 1 1 1 1 RsgA GTPase Ribosomal_S27e PF01667.17 ELR12296.1 - 0.0044 16.7 0.1 0.0085 15.8 0.1 1.4 1 0 0 1 1 1 1 Ribosomal protein S27 AIG1 PF04548.16 ELR12296.1 - 0.0079 15.5 0.0 0.015 14.6 0.0 1.4 1 0 0 1 1 1 1 AIG1 family Dynamin_N PF00350.23 ELR12296.1 - 0.008 16.2 0.0 0.016 15.3 0.0 1.6 1 0 0 1 1 1 1 Dynamin family AAA_29 PF13555.6 ELR12296.1 - 0.0099 15.6 0.0 0.021 14.5 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_23 PF13476.6 ELR12296.1 - 0.018 15.5 0.4 0.075 13.5 0.1 2.0 2 0 0 2 2 2 0 AAA domain A2L_zn_ribbon PF08792.10 ELR12296.1 - 0.022 14.5 2.1 0.04 13.6 2.1 1.4 1 0 0 1 1 1 0 A2L zinc ribbon domain ABC_tran PF00005.27 ELR12296.1 - 0.036 14.6 0.0 0.09 13.3 0.0 1.7 1 0 0 1 1 1 0 ABC transporter IIGP PF05049.13 ELR12296.1 - 0.042 12.9 0.1 0.091 11.8 0.0 1.6 2 0 0 2 2 2 0 Interferon-inducible GTPase (IIGP) FtsK_SpoIIIE PF01580.18 ELR12296.1 - 0.052 12.9 0.0 0.095 12.0 0.0 1.4 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_18 PF13238.6 ELR12296.1 - 0.065 13.8 0.0 0.14 12.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain Septin PF00735.18 ELR12296.1 - 0.082 12.2 0.5 1.2 8.3 0.0 2.5 2 1 1 3 3 3 0 Septin SMC_N PF02463.19 ELR12296.1 - 0.093 12.1 0.1 0.19 11.1 0.1 1.4 1 0 0 1 1 1 0 RecF/RecN/SMC N terminal domain TF_Zn_Ribbon PF08271.12 ELR12296.1 - 0.12 11.9 1.0 0.26 10.8 1.0 1.5 1 0 0 1 1 1 0 TFIIB zinc-binding NOB1_Zn_bind PF08772.11 ELR12296.1 - 0.16 12.1 1.7 0.33 11.1 1.1 1.7 1 1 0 1 1 1 0 Nin one binding (NOB1) Zn-ribbon like ACT_7 PF13840.6 ELR12298.1 - 4.7e-21 74.3 0.0 7.1e-21 73.8 0.0 1.3 1 0 0 1 1 1 1 ACT domain RRM_1 PF00076.22 ELR12299.1 - 3.1e-10 39.7 0.2 1.7e-09 37.3 0.2 2.2 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Cluap1 PF10234.9 ELR12299.1 - 0.01 15.2 1.3 0.017 14.5 1.3 1.3 1 0 0 1 1 1 0 Clusterin-associated protein-1 AKNA PF12443.8 ELR12299.1 - 6.3 7.5 9.9 1.8 9.2 1.3 3.5 2 2 2 4 4 4 0 AT-hook-containing transcription factor Rap_GAP PF02145.15 ELR12301.1 - 2.2e-45 154.5 0.0 1.1e-44 152.2 0.0 2.1 2 0 0 2 2 2 1 Rap/ran-GAP Cnn_1N PF07989.11 ELR12302.1 - 6.4e-15 55.1 4.4 6.4e-15 55.1 4.4 7.4 5 2 2 7 7 7 2 Centrosomin N-terminal motif 1 Shugoshin_N PF07558.11 ELR12302.1 - 0.72 9.8 13.9 2.7 7.9 0.1 4.5 4 0 0 4 4 4 0 Shugoshin N-terminal coiled-coil region TrkH PF02386.16 ELR12303.1 - 5.9e-69 232.8 19.2 8e-69 232.4 19.2 1.2 1 0 0 1 1 1 1 Cation transport protein Glyco_trans_1_3 PF13528.6 ELR12304.1 - 0.00016 21.0 0.0 0.0045 16.3 0.0 2.1 2 0 0 2 2 2 2 Glycosyl transferase family 1 ADP_ribosyl_GH PF03747.14 ELR12305.1 - 6.2e-42 144.3 2.5 9e-41 140.5 2.5 2.2 1 1 0 1 1 1 1 ADP-ribosylglycohydrolase Syja_N PF02383.18 ELR12306.1 - 3.1e-84 283.0 0.4 5.4e-84 282.2 0.4 1.4 1 0 0 1 1 1 1 SacI homology domain C2 PF00168.30 ELR12306.1 - 0.0027 18.0 0.0 0.0082 16.4 0.0 1.8 1 0 0 1 1 1 1 C2 domain Rhodanese PF00581.20 ELR12307.1 - 3.8e-05 24.2 0.0 3.8e-05 24.1 0.0 1.0 1 0 0 1 1 1 1 Rhodanese-like domain RNase_T PF00929.24 ELR12308.1 - 4.2e-23 82.7 0.0 6.7e-23 82.0 0.0 1.3 1 0 0 1 1 1 1 Exonuclease Ras PF00071.22 ELR12309.1 - 9.6e-48 161.8 0.1 1.1e-47 161.6 0.1 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR12309.1 - 3.8e-16 59.4 0.0 6.1e-16 58.7 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR12309.1 - 1.2e-05 24.9 0.0 1.4e-05 24.6 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 ELR12309.1 - 0.0019 17.8 0.5 0.0036 16.9 0.5 1.7 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain CbiA PF01656.23 ELR12309.1 - 0.024 14.7 0.6 0.19 11.8 0.6 2.1 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain Lipase_GDSL PF00657.22 ELR12309.1 - 0.17 11.8 0.0 0.24 11.4 0.0 1.2 1 0 0 1 1 1 0 GDSL-like Lipase/Acylhydrolase Dymeclin PF09742.9 ELR12310.1 - 4.2e-78 263.3 0.9 9e-55 186.3 1.2 2.0 1 1 1 2 2 2 2 Dyggve-Melchior-Clausen syndrome protein Hid1 PF12722.7 ELR12310.1 - 5.5e-05 21.5 2.9 0.067 11.3 0.1 3.4 3 1 0 3 3 3 3 High-temperature-induced dauer-formation protein SMI1_KNR4 PF09346.10 ELR12311.1 - 0.0002 21.8 0.0 0.0007 20.0 0.0 1.9 2 0 0 2 2 2 1 SMI1 / KNR4 family (SUKH-1) SUKH_5 PF14567.6 ELR12311.1 - 0.1 12.3 0.0 0.47 10.2 0.0 1.9 2 0 0 2 2 2 0 SMI1-KNR4 cell-wall Hexapep PF00132.24 ELR12312.1 - 2.3e-08 33.4 7.5 1.3e-06 27.8 0.5 3.7 3 1 1 4 4 4 2 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 ELR12312.1 - 0.06 13.1 0.1 0.06 13.1 0.1 3.5 3 0 0 3 3 3 0 Hexapeptide repeat of succinyl-transferase Ribosomal_S24e PF01282.19 ELR12312.1 - 0.11 12.5 0.0 0.21 11.6 0.0 1.4 1 0 0 1 1 1 0 Ribosomal protein S24e Bactofilin PF04519.13 ELR12312.1 - 0.13 12.6 0.5 0.37 11.1 0.4 1.9 1 1 1 2 2 2 0 Polymer-forming cytoskeletal DAPDH_C PF16654.5 ELR12315.1 - 0.00073 19.4 0.6 0.00086 19.2 0.6 1.1 1 0 0 1 1 1 1 Diaminopimelic acid dehydrogenase C-terminal domain DUF4820 PF16091.5 ELR12315.1 - 1.3 8.4 6.7 2.7 7.3 6.7 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4820) SNF2_N PF00176.23 ELR12316.1 - 3.7e-50 170.6 0.9 7.1e-50 169.7 0.9 1.3 1 1 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 ELR12316.1 - 8.9e-13 48.6 0.0 1.9e-12 47.5 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Chromo PF00385.24 ELR12316.1 - 4.5e-12 45.7 0.4 9.3e-12 44.7 0.4 1.6 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain ResIII PF04851.15 ELR12316.1 - 2.1e-11 44.1 0.0 4.2e-11 43.2 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.29 ELR12316.1 - 1.1e-05 25.3 0.0 1.8e-05 24.6 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase HDA2-3 PF11496.8 ELR12316.1 - 0.0014 17.9 0.0 0.0021 17.3 0.0 1.3 1 0 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 CheR PF01739.18 ELR12317.1 - 0.11 11.9 0.0 0.21 11.0 0.0 1.4 1 0 0 1 1 1 0 CheR methyltransferase, SAM binding domain Gelsolin PF00626.22 ELR12318.1 - 2.4e-48 161.9 0.0 1.3e-09 37.9 0.0 6.6 6 0 0 6 6 6 6 Gelsolin repeat Cyto_heme_lyase PF01265.17 ELR12319.1 - 3.5e-52 177.8 5.5 5.7e-29 101.6 0.7 2.0 1 1 1 2 2 2 2 Cytochrome c/c1 heme lyase Spc7 PF08317.11 ELR12320.1 - 0.00069 18.6 14.0 0.00085 18.3 14.0 1.1 1 0 0 1 1 1 1 Spc7 kinetochore protein BcsB PF03170.13 ELR12320.1 - 0.0032 15.9 0.2 0.0037 15.7 0.2 1.1 1 0 0 1 1 1 1 Bacterial cellulose synthase subunit Uso1_p115_C PF04871.13 ELR12320.1 - 0.0034 17.8 18.1 0.0052 17.1 18.1 1.3 1 0 0 1 1 1 1 Uso1 / p115 like vesicle tethering protein, C terminal region CENP-F_leu_zip PF10473.9 ELR12320.1 - 0.018 15.1 10.3 0.018 15.1 10.3 1.6 1 1 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF3450 PF11932.8 ELR12320.1 - 0.03 13.6 16.3 0.036 13.4 7.5 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) PV-1 PF06637.11 ELR12320.1 - 0.044 12.6 8.6 0.055 12.3 8.6 1.1 1 0 0 1 1 1 0 PV-1 protein (PLVAP) FliD_N PF02465.18 ELR12320.1 - 0.081 13.6 2.3 0.11 13.2 1.4 1.7 1 1 1 2 2 2 0 Flagellar hook-associated protein 2 N-terminus DUF1090 PF06476.12 ELR12320.1 - 0.083 13.0 14.6 0.65 10.1 7.9 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1090) kleA_kleC PF17383.2 ELR12320.1 - 0.11 12.9 8.1 0.12 12.8 1.8 2.5 1 1 1 2 2 2 0 Uncharacterized KorC regulated protein A DUF4047 PF13256.6 ELR12320.1 - 0.14 12.3 2.4 0.19 11.9 2.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4047) Sec2p PF06428.11 ELR12320.1 - 0.16 12.0 13.2 0.067 13.2 6.5 2.4 1 1 1 2 2 2 0 GDP/GTP exchange factor Sec2p PIN_8 PF18476.1 ELR12320.1 - 0.17 11.7 5.4 0.2 11.5 5.4 1.2 1 0 0 1 1 1 0 PIN like domain AAA_13 PF13166.6 ELR12320.1 - 0.18 10.4 7.2 0.2 10.3 7.2 1.1 1 0 0 1 1 1 0 AAA domain APG6_N PF17675.1 ELR12320.1 - 0.22 12.1 19.2 0.068 13.7 16.5 1.6 1 1 0 1 1 1 0 Apg6 coiled-coil region LUC7 PF03194.15 ELR12320.1 - 0.31 10.6 9.8 0.24 11.0 8.7 1.3 1 1 0 1 1 1 0 LUC7 N_terminus HrpB7 PF09486.10 ELR12320.1 - 0.33 11.3 19.2 0.09 13.2 10.5 2.0 1 1 1 2 2 2 0 Bacterial type III secretion protein (HrpB7) DUF1664 PF07889.12 ELR12320.1 - 0.41 10.7 4.4 1.4 9.0 3.8 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) BST2 PF16716.5 ELR12320.1 - 0.47 11.1 13.4 0.17 12.5 10.3 1.8 1 1 1 2 2 2 0 Bone marrow stromal antigen 2 DUF724 PF05266.14 ELR12320.1 - 0.52 10.1 9.8 0.59 9.9 8.1 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF724) DUF4407 PF14362.6 ELR12320.1 - 0.86 8.9 10.2 1.1 8.6 10.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) KxDL PF10241.9 ELR12320.1 - 1.3 9.4 12.4 1.4 9.3 5.0 2.2 1 1 1 2 2 2 0 Uncharacterized conserved protein THOC7 PF05615.13 ELR12320.1 - 1.3 9.3 12.7 1.8 8.9 12.7 1.3 1 0 0 1 1 1 0 Tho complex subunit 7 DUF4200 PF13863.6 ELR12320.1 - 1.4 9.4 14.1 2.7 8.4 13.8 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4200) UPF0242 PF06785.11 ELR12320.1 - 1.4 8.9 15.3 1.9 8.5 15.3 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus FUSC PF04632.12 ELR12320.1 - 2.1 6.8 9.6 2.5 6.6 9.6 1.0 1 0 0 1 1 1 0 Fusaric acid resistance protein family OmpH PF03938.14 ELR12320.1 - 2.8 8.3 15.9 1.8 8.9 12.3 2.0 1 1 1 2 2 2 0 Outer membrane protein (OmpH-like) AAA_11 PF13086.6 ELR12320.1 - 3 7.5 9.6 3.6 7.3 9.6 1.1 1 0 0 1 1 1 0 AAA domain Swi5 PF07061.11 ELR12320.1 - 4.2 7.5 10.3 8.8 6.5 3.6 2.6 1 1 1 2 2 2 0 Swi5 Neur_chan_memb PF02932.16 ELR12320.1 - 6 6.9 6.7 7.1 6.6 6.7 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Atg14 PF10186.9 ELR12320.1 - 6.1 5.8 10.7 8.4 5.4 10.7 1.3 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DivIC PF04977.15 ELR12320.1 - 6.3 6.6 14.3 2.3 8.1 2.5 2.9 1 1 2 3 3 3 0 Septum formation initiator AAA_23 PF13476.6 ELR12320.1 - 9.1 6.7 9.7 11 6.4 9.7 1.2 1 0 0 1 1 1 0 AAA domain ANAPC4_WD40 PF12894.7 ELR12322.1 - 4.7e-12 46.0 1.1 0.0024 18.1 0.0 4.2 4 1 0 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 ELR12322.1 - 1.4e-11 44.8 12.0 0.041 14.8 0.4 6.3 7 0 0 7 7 7 3 WD domain, G-beta repeat eIF2A PF08662.11 ELR12322.1 - 0.0095 15.8 4.2 0.011 15.6 0.3 2.8 2 1 1 3 3 3 1 Eukaryotic translation initiation factor eIF2A LytB_WW PF18342.1 ELR12322.1 - 0.18 11.9 0.0 0.41 10.8 0.0 1.6 1 0 0 1 1 1 0 Endo-beta-N-acetylglucosaminidase LytB WW domain Methyltransf_23 PF13489.6 ELR12323.1 - 1.8e-12 47.4 0.0 3.2e-12 46.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ELR12323.1 - 7.6e-12 45.8 0.0 7.6e-12 45.8 0.0 2.1 3 0 0 3 3 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 ELR12323.1 - 9.1e-12 45.5 0.1 1.8e-11 44.6 0.1 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ELR12323.1 - 1e-11 45.3 0.0 2.1e-11 44.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ELR12323.1 - 5.8e-08 32.7 0.0 9.3e-08 32.0 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_9 PF08003.11 ELR12323.1 - 0.00085 18.3 0.8 0.002 17.1 0.0 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF1698) NodS PF05401.11 ELR12323.1 - 0.00096 18.8 0.0 0.0015 18.2 0.0 1.2 1 0 0 1 1 1 1 Nodulation protein S (NodS) MTS PF05175.14 ELR12323.1 - 0.0011 18.5 0.0 0.0026 17.3 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_32 PF13679.6 ELR12323.1 - 0.0019 18.2 0.8 0.0062 16.5 0.8 2.0 1 1 0 1 1 1 1 Methyltransferase domain MetW PF07021.12 ELR12323.1 - 0.0035 17.0 0.0 0.0057 16.3 0.0 1.2 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW DUF2058 PF09831.9 ELR12323.1 - 0.011 16.0 1.6 0.018 15.2 1.6 1.5 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2058) TPMT PF05724.11 ELR12323.1 - 0.015 14.9 0.0 0.032 13.9 0.0 1.5 1 0 0 1 1 1 0 Thiopurine S-methyltransferase (TPMT) CMAS PF02353.20 ELR12323.1 - 0.046 13.0 0.0 0.088 12.1 0.0 1.4 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Alk_phosphatase PF00245.20 ELR12324.1 - 5.9e-48 163.8 7.4 1.2e-47 162.8 7.4 1.5 1 1 0 1 1 1 1 Alkaline phosphatase TPR_1 PF00515.28 ELR12327.1 - 8.7e-29 98.1 19.6 2.2e-06 27.2 0.2 7.9 8 0 0 8 8 8 5 Tetratricopeptide repeat TPR_2 PF07719.17 ELR12327.1 - 4.9e-27 91.8 21.5 2.9e-05 23.8 0.1 7.6 8 0 0 8 8 8 6 Tetratricopeptide repeat TPR_16 PF13432.6 ELR12327.1 - 9.8e-20 70.9 15.5 3e-05 24.6 0.3 5.7 2 2 4 6 6 6 5 Tetratricopeptide repeat TPR_11 PF13414.6 ELR12327.1 - 1.8e-18 65.9 19.7 4.3e-08 32.7 0.1 6.7 3 2 5 8 8 8 5 TPR repeat TPR_12 PF13424.6 ELR12327.1 - 6.9e-18 64.7 20.5 1.7e-05 25.0 2.6 4.5 3 1 1 4 4 4 4 Tetratricopeptide repeat TPR_17 PF13431.6 ELR12327.1 - 2.9e-16 58.6 9.2 0.0016 18.7 0.0 6.4 7 0 0 7 7 7 4 Tetratricopeptide repeat TPR_8 PF13181.6 ELR12327.1 - 8.6e-15 53.6 15.5 0.017 15.3 0.0 7.1 8 0 0 8 8 7 5 Tetratricopeptide repeat TPR_6 PF13174.6 ELR12327.1 - 1.4e-12 47.4 5.7 0.067 13.9 0.0 6.5 6 0 0 6 6 6 2 Tetratricopeptide repeat ANAPC3 PF12895.7 ELR12327.1 - 1.7e-12 47.4 13.2 5.7e-08 32.9 0.4 3.9 1 1 3 4 4 4 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.6 ELR12327.1 - 5.1e-10 39.7 8.4 0.018 15.6 0.4 4.4 1 1 5 6 6 6 4 Tetratricopeptide repeat TPR_14 PF13428.6 ELR12327.1 - 3.4e-09 36.8 4.6 0.1 13.5 0.0 6.0 2 2 4 6 6 6 2 Tetratricopeptide repeat TPR_10 PF13374.6 ELR12327.1 - 8.8e-09 35.0 17.0 0.00028 20.7 0.1 6.2 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_9 PF13371.6 ELR12327.1 - 9e-08 32.2 4.1 0.39 10.9 0.1 4.5 2 2 2 4 4 4 3 Tetratricopeptide repeat TPR_4 PF07721.14 ELR12327.1 - 1e-07 31.8 9.8 0.57 11.0 0.1 5.7 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_7 PF13176.6 ELR12327.1 - 0.00013 21.8 14.5 0.71 10.0 0.0 6.6 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_15 PF13429.6 ELR12327.1 - 0.0012 18.1 1.4 0.0012 18.1 1.4 2.7 2 1 1 3 3 3 1 Tetratricopeptide repeat DUF3856 PF12968.7 ELR12327.1 - 0.018 15.1 0.5 2.6 8.1 0.1 3.4 1 1 1 3 3 3 0 Domain of Unknown Function (DUF3856) DUF4919 PF16266.5 ELR12327.1 - 0.057 13.4 0.3 0.75 9.7 0.0 2.3 2 1 1 3 3 3 0 Domain of unknown function (DUF4919) EST1_DNA_bind PF10373.9 ELR12327.1 - 0.2 11.1 4.4 1.5 8.2 0.1 2.5 2 1 0 2 2 2 0 Est1 DNA/RNA binding domain BTAD PF03704.17 ELR12327.1 - 0.62 10.5 7.3 6.4 7.2 0.1 3.5 1 1 1 2 2 2 0 Bacterial transcriptional activator domain MIT PF04212.18 ELR12327.1 - 5.1 7.2 16.6 6.2 7.0 0.4 5.0 3 2 2 5 5 5 0 MIT (microtubule interacting and transport) domain Glyco_transf_41 PF13844.6 ELR12328.1 - 4.9e-27 94.5 0.0 1.9e-17 62.9 0.0 2.1 2 0 0 2 2 2 2 Glycosyl transferase family 41 BLOC1_2 PF10046.9 ELR12329.1 - 0.0047 17.2 0.4 0.0065 16.7 0.4 1.3 1 0 0 1 1 1 1 Biogenesis of lysosome-related organelles complex-1 subunit 2 Spc7 PF08317.11 ELR12329.1 - 0.037 12.9 0.2 0.047 12.6 0.2 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein Plk4_PB2 PF18409.1 ELR12329.1 - 0.038 14.7 0.5 0.049 14.3 0.5 1.2 1 0 0 1 1 1 0 Polo-like Kinase 4 Polo Box 2 Prefoldin PF02996.17 ELR12329.1 - 0.04 13.8 0.3 0.063 13.2 0.0 1.5 2 0 0 2 2 2 0 Prefoldin subunit DASH_Dad3 PF08656.10 ELR12329.1 - 0.081 13.0 0.1 0.13 12.4 0.1 1.4 1 0 0 1 1 1 0 DASH complex subunit Dad3 SPOB_a PF14689.6 ELR12329.1 - 0.12 12.0 0.0 0.2 11.4 0.0 1.4 1 0 0 1 1 1 0 Sensor_kinase_SpoOB-type, alpha-helical domain NEMO PF11577.8 ELR12330.1 - 0.0013 18.7 3.6 0.15 12.1 1.6 2.7 2 0 0 2 2 2 1 NF-kappa-B essential modulator NEMO ATG16 PF08614.11 ELR12330.1 - 0.0045 17.2 13.8 0.14 12.4 0.5 2.3 1 1 1 2 2 2 2 Autophagy protein 16 (ATG16) Aminotran_1_2 PF00155.21 ELR12330.1 - 0.024 13.8 0.2 0.13 11.4 0.0 1.9 1 1 1 2 2 2 0 Aminotransferase class I and II DUF5098 PF17023.5 ELR12330.1 - 0.031 13.2 3.2 0.042 12.8 3.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5098) Fib_alpha PF08702.10 ELR12330.1 - 0.032 14.4 3.9 0.12 12.6 1.4 2.4 2 1 0 2 2 2 0 Fibrinogen alpha/beta chain family CENP-F_leu_zip PF10473.9 ELR12330.1 - 0.038 14.0 17.2 3.1 7.8 11.7 3.1 2 1 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 CASP_C PF08172.12 ELR12330.1 - 0.042 13.2 6.3 0.016 14.6 1.7 2.2 2 0 0 2 2 2 0 CASP C terminal Fungal_TACC PF12709.7 ELR12330.1 - 0.044 14.2 7.6 2.2 8.8 0.4 3.3 2 1 0 3 3 3 0 Fungal Transforming acidic coiled-coil (TACC) proteins UPF0242 PF06785.11 ELR12330.1 - 0.086 12.9 6.8 7.4 6.6 5.3 2.2 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus DUF3416 PF11896.8 ELR12330.1 - 0.11 12.7 4.5 0.35 11.2 4.5 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF3416) Leu_zip PF15294.6 ELR12330.1 - 0.15 11.5 11.6 1.7 8.1 0.0 2.4 2 1 0 2 2 2 0 Leucine zipper Chibby PF14645.6 ELR12330.1 - 0.18 12.2 2.3 0.32 11.4 1.8 1.6 2 0 0 2 2 1 0 Chibby family Tup_N PF08581.10 ELR12330.1 - 0.2 12.0 11.0 6.8 7.1 0.4 3.8 2 1 2 4 4 4 0 Tup N-terminal DUF3450 PF11932.8 ELR12330.1 - 0.23 10.7 10.0 0.79 9.0 6.4 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF3450) Golgin_A5 PF09787.9 ELR12330.1 - 0.25 10.8 11.3 0.78 9.2 8.7 2.1 2 0 0 2 2 2 0 Golgin subfamily A member 5 DUF3347 PF11827.8 ELR12330.1 - 0.28 11.4 4.1 0.52 10.5 4.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3347) FlaC_arch PF05377.11 ELR12330.1 - 0.35 11.3 3.4 1.5 9.3 0.1 3.2 4 1 0 4 4 4 0 Flagella accessory protein C (FlaC) SKA2 PF16740.5 ELR12330.1 - 0.37 10.6 12.5 6.6 6.6 1.9 3.2 3 0 0 3 3 3 0 Spindle and kinetochore-associated protein 2 ADIP PF11559.8 ELR12330.1 - 0.42 10.7 19.6 5 7.2 13.0 3.2 3 1 1 4 4 3 0 Afadin- and alpha -actinin-Binding ZapB PF06005.12 ELR12330.1 - 0.78 10.2 20.2 0.13 12.7 1.2 3.3 3 1 0 4 4 3 0 Cell division protein ZapB Striatin PF08232.12 ELR12330.1 - 0.97 10.0 10.0 13 6.3 6.8 2.7 2 1 1 3 3 3 0 Striatin family Cep57_CLD_2 PF14197.6 ELR12330.1 - 1.5 8.9 13.6 9.1 6.5 0.9 3.9 3 2 1 4 4 4 0 Centrosome localisation domain of PPC89 TMPIT PF07851.13 ELR12330.1 - 1.7 7.8 8.9 0.16 11.2 4.7 1.3 2 0 0 2 2 2 0 TMPIT-like protein DUF3584 PF12128.8 ELR12330.1 - 2 5.8 16.8 0.51 7.8 0.2 2.6 2 1 1 3 3 3 0 Protein of unknown function (DUF3584) ABC_tran_CTD PF16326.5 ELR12330.1 - 2 8.7 17.7 0.075 13.3 2.1 3.4 3 1 1 4 4 3 0 ABC transporter C-terminal domain DUF1974 PF09317.11 ELR12330.1 - 3 7.3 8.2 0.46 10.0 4.2 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF1974) Rootletin PF15035.6 ELR12330.1 - 4.2 7.4 13.3 1.5 8.8 8.7 2.0 2 0 0 2 2 2 0 Ciliary rootlet component, centrosome cohesion Swi5 PF07061.11 ELR12330.1 - 5.9 7.0 11.4 0.94 9.6 0.3 3.3 2 1 1 3 3 3 0 Swi5 DivIC PF04977.15 ELR12330.1 - 6.3 6.6 16.7 13 5.6 2.7 3.8 3 1 0 4 4 4 0 Septum formation initiator SdrD_B PF17210.3 ELR12331.1 - 4.7e-44 149.2 8.5 1.7e-14 54.0 0.2 3.2 3 0 0 3 3 3 3 SdrD B-like domain CarboxypepD_reg PF13620.6 ELR12331.1 - 3.1e-21 75.4 8.2 9.5e-07 29.0 0.0 4.2 4 1 0 4 4 4 3 Carboxypeptidase regulatory-like domain SpaA PF17802.1 ELR12331.1 - 1.8e-13 50.6 4.1 0.0015 18.8 0.1 3.6 3 0 0 3 3 3 3 Prealbumin-like fold domain CarbopepD_reg_2 PF13715.6 ELR12331.1 - 7e-08 32.4 2.4 0.2 11.7 0.1 3.9 3 0 0 3 3 3 3 CarboxypepD_reg-like domain DUF2012 PF09430.10 ELR12331.1 - 4.1e-06 26.9 0.2 0.046 13.8 0.0 3.4 3 0 0 3 3 3 2 Protein of unknown function (DUF2012) EMP24_GP25L PF01105.24 ELR12331.1 - 0.00016 21.7 1.2 0.0059 16.6 0.0 2.9 2 1 0 3 3 3 1 emp24/gp25L/p24 family/GOLD Dioxygenase_C PF00775.21 ELR12331.1 - 0.00034 20.1 0.1 1 8.7 0.0 3.3 3 0 0 3 3 3 2 Dioxygenase Big_1 PF02369.16 ELR12331.1 - 0.00042 20.3 3.1 0.11 12.6 0.4 3.4 3 0 0 3 3 3 1 Bacterial Ig-like domain (group 1) MetallophosN PF16371.5 ELR12331.1 - 0.00056 20.1 5.2 0.064 13.5 0.3 4.0 3 1 0 3 3 3 1 N terminal of Calcineurin-like phosphoesterase phage_tail_N PF08400.10 ELR12331.1 - 0.00078 19.4 1.9 1.2 9.1 0.1 3.3 3 0 0 3 3 3 2 Prophage tail fibre N-terminal DUF4198 PF10670.9 ELR12331.1 - 0.0017 18.7 1.7 7 6.9 0.0 3.5 3 1 0 3 3 3 2 Domain of unknown function (DUF4198) FixH PF05751.11 ELR12331.1 - 0.029 14.4 0.1 1.6 8.7 0.0 3.1 3 0 0 3 3 3 0 FixH fn3_3 PF14686.6 ELR12331.1 - 0.033 14.0 2.5 0.46 10.3 0.0 3.4 3 0 0 3 3 3 0 Polysaccharide lyase family 4, domain II Cna_B PF05738.13 ELR12331.1 - 0.036 14.6 1.0 1.7 9.2 0.1 3.1 3 0 0 3 3 3 0 Cna protein B-type domain Y_Y_Y PF07495.13 ELR12331.1 - 0.068 13.1 3.3 15 5.6 0.0 3.8 3 1 0 3 3 3 0 Y_Y_Y domain PPC PF04151.15 ELR12331.1 - 0.6 11.2 7.0 2.9 9.1 0.0 3.4 3 2 0 3 3 3 0 Bacterial pre-peptidase C-terminal domain EFP_N PF08207.12 ELR12332.1 - 1.9e-11 43.8 0.0 4.6e-11 42.6 0.0 1.7 1 0 0 1 1 1 1 Elongation factor P (EF-P) KOW-like domain Elong-fact-P_C PF09285.11 ELR12332.1 - 2.3e-10 40.1 0.3 7.4e-10 38.4 0.3 1.9 1 0 0 1 1 1 1 Elongation factor P, C-terminal EFP PF01132.20 ELR12332.1 - 1.7e-05 24.7 0.0 3.3e-05 23.8 0.0 1.5 1 0 0 1 1 1 1 Elongation factor P (EF-P) OB domain PPP4R2 PF09184.11 ELR12332.1 - 0.0032 17.1 8.2 0.0043 16.7 8.2 1.3 1 0 0 1 1 1 1 PPP4R2 CDC45 PF02724.14 ELR12332.1 - 0.1 10.9 10.5 0.14 10.5 10.5 1.2 1 0 0 1 1 1 0 CDC45-like protein RNA_pol_3_Rpc31 PF11705.8 ELR12332.1 - 0.15 12.3 16.9 0.031 14.5 13.6 1.6 2 0 0 2 2 2 0 DNA-directed RNA polymerase III subunit Rpc31 TFIIA PF03153.13 ELR12332.1 - 0.19 11.7 12.2 0.26 11.2 12.2 1.3 1 1 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Sporozoite_P67 PF05642.11 ELR12332.1 - 0.38 8.8 6.7 0.28 9.2 5.5 1.5 2 0 0 2 2 2 0 Sporozoite P67 surface antigen TFB6 PF17110.5 ELR12332.1 - 0.45 10.3 5.5 0.71 9.6 5.5 1.4 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH NOA36 PF06524.12 ELR12332.1 - 0.63 9.3 24.2 1.1 8.5 24.2 1.3 1 0 0 1 1 1 0 NOA36 protein Nop14 PF04147.12 ELR12332.1 - 0.72 8.0 16.9 0.94 7.6 16.9 1.1 1 0 0 1 1 1 0 Nop14-like family RXT2_N PF08595.11 ELR12332.1 - 1.1 9.2 10.9 0.3 11.1 7.4 1.9 2 0 0 2 2 2 0 RXT2-like, N-terminal Cwf_Cwc_15 PF04889.12 ELR12332.1 - 1.9 8.1 19.1 0.46 10.2 15.3 1.8 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein SDA1 PF05285.12 ELR12332.1 - 5.5 6.3 19.9 0.31 10.4 15.0 1.4 2 0 0 2 2 2 0 SDA1 MFS_1 PF07690.16 ELR12333.1 - 1.8e-54 185.0 62.1 1.7e-46 158.8 36.0 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.7 ELR12333.1 - 1.6e-09 37.1 8.2 1.6e-09 37.1 8.2 2.4 1 1 1 2 2 2 1 MFS_1 like family MFS_2 PF13347.6 ELR12333.1 - 6.6e-09 34.8 18.9 4.4e-07 28.8 4.9 2.2 2 0 0 2 2 2 2 MFS/sugar transport protein Sugar_tr PF00083.24 ELR12333.1 - 1.2e-07 31.0 6.2 1.2e-07 31.0 6.2 2.7 2 1 0 3 3 3 1 Sugar (and other) transporter MFS_4 PF06779.14 ELR12333.1 - 5.9e-05 22.5 25.4 0.00077 18.9 26.1 2.3 1 1 0 1 1 1 1 Uncharacterised MFS-type transporter YbfB MFS_3 PF05977.13 ELR12333.1 - 0.00024 19.7 20.7 0.0027 16.2 20.7 2.3 1 1 0 1 1 1 1 Transmembrane secretion effector Peptidase_M15 PF01427.17 ELR12334.1 - 3.1e-36 125.0 0.1 5.1e-36 124.3 0.1 1.3 1 1 0 1 1 1 1 D-ala-D-ala dipeptidase VanY PF02557.17 ELR12334.1 - 9.1e-05 22.3 1.0 0.00063 19.5 1.0 2.1 1 1 0 1 1 1 1 D-alanyl-D-alanine carboxypeptidase Peptidase_M15_4 PF13539.6 ELR12334.1 - 0.026 15.0 0.1 0.061 13.8 0.1 1.6 1 0 0 1 1 1 0 D-alanyl-D-alanine carboxypeptidase RVT_2 PF07727.14 ELR12335.1 - 2.5e-39 135.4 0.0 1.1e-38 133.2 0.0 1.9 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Retrotran_gag_2 PF14223.6 ELR12337.1 - 1.2e-12 47.6 2.2 1.2e-12 47.6 2.2 1.8 2 0 0 2 2 2 1 gag-polypeptide of LTR copia-type zf-C2HE PF16278.5 ELR12337.1 - 0.0029 18.0 1.6 0.09 13.2 0.4 3.1 3 0 0 3 3 3 1 C2HE / C2H2 / C2HC zinc-binding finger UvrC_HhH_N PF08459.11 ELR12337.1 - 0.026 14.4 0.0 0.063 13.2 0.0 1.9 1 1 0 1 1 1 0 UvrC Helix-hairpin-helix N-terminal YxiJ PF14176.6 ELR12337.1 - 0.16 12.5 1.1 0.28 11.7 0.3 1.9 2 0 0 2 2 2 0 YxiJ-like protein Rad51 PF08423.11 ELR12339.1 - 8.5e-29 100.6 0.0 1.1e-28 100.2 0.0 1.1 1 0 0 1 1 1 1 Rad51 AAA_25 PF13481.6 ELR12339.1 - 2.9e-05 23.8 0.0 4.6e-05 23.1 0.0 1.3 1 0 0 1 1 1 1 AAA domain DnaB_C PF03796.15 ELR12339.1 - 0.00012 21.6 0.1 0.00016 21.1 0.1 1.2 1 0 0 1 1 1 1 DnaB-like helicase C terminal domain ATPase PF06745.13 ELR12339.1 - 0.029 13.7 0.0 0.055 12.8 0.1 1.5 2 0 0 2 2 2 0 KaiC GAF_2 PF13185.6 ELR12340.1 - 3.4e-08 33.9 0.0 4.5e-08 33.5 0.0 1.3 1 1 0 1 1 1 1 GAF domain GAF PF01590.26 ELR12340.1 - 3e-05 24.7 0.0 3.7e-05 24.4 0.0 1.2 1 0 0 1 1 1 1 GAF domain Flu_NP PF00506.18 ELR12340.1 - 0.0051 15.5 0.0 0.0072 15.0 0.0 1.1 1 0 0 1 1 1 1 Influenza virus nucleoprotein GAF_3 PF13492.6 ELR12340.1 - 0.069 13.5 0.0 0.12 12.7 0.0 1.4 1 0 0 1 1 1 0 GAF domain Peptidase_C78 PF07910.13 ELR12341.1 - 1.4e-59 201.1 0.0 2.9e-42 144.5 0.0 2.3 2 0 0 2 2 2 2 Peptidase family C78 Peptidase_C54 PF03416.19 ELR12341.1 - 0.12 11.7 0.2 0.3 10.5 0.1 1.7 2 0 0 2 2 2 0 Peptidase family C54 E_Pc_C PF06752.12 ELR12341.1 - 2.8 8.0 6.1 5 7.2 6.1 1.3 1 0 0 1 1 1 0 Enhancer of Polycomb C-terminus Thioredoxin PF00085.20 ELR12342.1 - 4.5e-60 200.0 0.5 9.9e-31 105.8 0.1 2.8 3 0 0 3 3 3 2 Thioredoxin Thioredoxin_6 PF13848.6 ELR12342.1 - 3.9e-19 69.3 0.0 2.5e-12 47.1 0.0 3.3 2 1 1 3 3 3 3 Thioredoxin-like domain Thioredoxin_2 PF13098.6 ELR12342.1 - 7.4e-11 42.5 1.6 3.5e-05 24.2 0.1 3.0 2 2 0 2 2 2 2 Thioredoxin-like domain OST3_OST6 PF04756.13 ELR12342.1 - 5.8e-10 39.0 0.0 2.6e-05 23.7 0.0 2.2 2 0 0 2 2 2 2 OST3 / OST6 family, transporter family Thioredoxin_7 PF13899.6 ELR12342.1 - 1.9e-07 31.2 0.2 0.00046 20.3 0.0 2.7 2 0 0 2 2 2 2 Thioredoxin-like Thioredoxin_8 PF13905.6 ELR12342.1 - 3.8e-07 30.3 0.0 0.045 14.1 0.0 3.5 2 1 1 3 3 3 2 Thioredoxin-like AhpC-TSA PF00578.21 ELR12342.1 - 8.4e-07 28.9 0.5 0.1 12.5 0.0 3.4 2 1 1 3 3 3 2 AhpC/TSA family Thioredoxin_4 PF13462.6 ELR12342.1 - 0.0021 18.2 0.2 1.4 9.1 0.0 3.0 2 1 1 3 3 3 1 Thioredoxin Redoxin PF08534.10 ELR12342.1 - 0.0027 17.4 0.1 0.84 9.3 0.0 2.6 2 0 0 2 2 2 2 Redoxin TraF PF13728.6 ELR12342.1 - 0.0046 16.8 0.1 3.8 7.3 0.0 3.0 3 0 0 3 3 3 2 F plasmid transfer operon protein HyaE PF07449.11 ELR12342.1 - 0.034 14.1 0.0 19 5.3 0.0 3.2 3 0 0 3 3 3 0 Hydrogenase-1 expression protein HyaE Zn_clus PF00172.18 ELR12343.1 - 0.00022 21.3 10.6 0.00037 20.6 10.6 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain PAS_8 PF13188.7 ELR12343.1 - 0.018 15.0 0.0 0.054 13.5 0.0 1.8 2 0 0 2 2 2 0 PAS domain MEKHLA PF08670.11 ELR12343.1 - 0.048 13.6 0.0 0.082 12.8 0.0 1.3 1 0 0 1 1 1 0 MEKHLA domain PAS PF00989.25 ELR12343.1 - 0.082 12.9 0.0 0.16 12.0 0.0 1.4 1 0 0 1 1 1 0 PAS fold Pkinase_Tyr PF07714.17 ELR12344.1 - 1.4e-60 204.8 0.0 1.9e-60 204.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ELR12344.1 - 1.4e-52 178.7 0.0 1.9e-52 178.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.23 ELR12344.1 - 0.0012 18.8 0.0 0.0029 17.6 0.0 1.6 2 0 0 2 2 2 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 ELR12344.1 - 0.02 13.9 0.0 0.038 12.9 0.0 1.4 1 0 0 1 1 1 0 Haspin like kinase domain RIO1 PF01163.22 ELR12344.1 - 0.12 12.0 0.0 0.2 11.2 0.0 1.3 1 0 0 1 1 1 0 RIO1 family Thioredoxin PF00085.20 ELR12345.1 - 7.2e-57 189.7 0.0 1.5e-28 98.8 0.0 2.6 2 0 0 2 2 2 2 Thioredoxin Thioredoxin_6 PF13848.6 ELR12345.1 - 1e-13 51.6 0.0 3.5e-08 33.6 0.0 3.4 2 1 1 3 3 3 2 Thioredoxin-like domain Thioredoxin_2 PF13098.6 ELR12345.1 - 7.6e-09 36.0 2.0 0.0032 17.9 0.0 3.7 3 1 0 3 3 3 2 Thioredoxin-like domain Thioredoxin_7 PF13899.6 ELR12345.1 - 6e-08 32.8 0.1 0.0074 16.5 0.0 2.9 2 0 0 2 2 2 2 Thioredoxin-like AhpC-TSA PF00578.21 ELR12345.1 - 8.1e-06 25.8 0.2 0.14 12.1 0.1 3.2 2 1 1 3 3 3 2 AhpC/TSA family Thioredoxin_8 PF13905.6 ELR12345.1 - 4.1e-05 23.8 0.0 0.58 10.5 0.0 2.9 2 0 0 2 2 2 2 Thioredoxin-like OST3_OST6 PF04756.13 ELR12345.1 - 0.00017 21.0 0.1 0.055 12.8 0.0 2.5 2 1 0 2 2 2 2 OST3 / OST6 family, transporter family ERp29_N PF07912.13 ELR12345.1 - 0.0052 16.9 0.1 4 7.6 0.0 2.8 2 1 0 2 2 2 2 ERp29, N-terminal domain HyaE PF07449.11 ELR12345.1 - 0.007 16.3 0.0 0.037 14.0 0.0 2.2 2 0 0 2 2 2 1 Hydrogenase-1 expression protein HyaE Redoxin PF08534.10 ELR12345.1 - 0.011 15.4 0.1 1.8 8.3 0.0 2.8 2 0 0 2 2 2 0 Redoxin TraF PF13728.6 ELR12345.1 - 0.12 12.2 5.2 3.5 7.4 0.0 3.1 2 1 1 3 3 3 0 F plasmid transfer operon protein Thioredoxin_4 PF13462.6 ELR12345.1 - 1.1 9.4 5.4 2.8 8.1 0.0 3.1 2 1 1 3 3 3 0 Thioredoxin BRCT PF00533.26 ELR12347.1 - 3.7e-22 78.5 0.0 9.3e-13 48.4 0.0 2.5 2 0 0 2 2 2 2 BRCA1 C Terminus (BRCT) domain XRCC1_N PF01834.16 ELR12347.1 - 1.1e-21 77.4 0.0 1.9e-21 76.6 0.0 1.3 1 0 0 1 1 1 1 XRCC1 N terminal domain PTCB-BRCT PF12738.7 ELR12347.1 - 1.2e-16 60.4 0.0 7.7e-10 38.6 0.0 2.7 3 0 0 3 3 3 2 twin BRCT domain BRCT_2 PF16589.5 ELR12347.1 - 2.8e-16 59.7 0.0 6.1e-07 29.8 0.0 2.4 2 0 0 2 2 2 2 BRCT domain, a BRCA1 C-terminus domain LIG3_BRCT PF16759.5 ELR12347.1 - 3e-09 37.0 0.0 4.3e-07 30.1 0.0 2.6 2 0 0 2 2 2 1 DNA ligase 3 BRCT domain SET PF00856.28 ELR12348.1 - 2e-09 38.0 0.0 3.5e-09 37.3 0.0 1.4 1 1 0 1 1 1 1 SET domain Ser_hydrolase PF06821.13 ELR12350.1 - 1.4e-05 25.0 0.0 0.15 11.9 0.0 2.2 2 0 0 2 2 2 2 Serine hydrolase Abhydrolase_6 PF12697.7 ELR12350.1 - 0.077 13.6 0.1 2.7 8.6 0.0 2.1 1 1 1 2 2 2 0 Alpha/beta hydrolase family RasGEF PF00617.19 ELR12351.1 - 2.2e-18 67.1 2.2 8.2e-15 55.4 0.1 3.7 2 1 1 3 3 3 2 RasGEF domain Ser_hydrolase PF06821.13 ELR12352.1 - 1.4e-08 34.8 0.0 2.4e-08 34.0 0.0 1.5 1 1 0 1 1 1 1 Serine hydrolase Abhydrolase_1 PF00561.20 ELR12352.1 - 0.00011 22.0 0.0 0.0017 18.1 0.0 2.0 1 1 1 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 ELR12352.1 - 0.00091 19.9 0.0 0.0012 19.5 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family DUF1057 PF06342.12 ELR12352.1 - 0.015 14.3 0.1 0.038 13.0 0.0 1.6 2 0 0 2 2 2 0 Alpha/beta hydrolase of unknown function (DUF1057) DUF3089 PF11288.8 ELR12352.1 - 0.023 14.2 0.0 0.034 13.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3089) ERG2_Sigma1R PF04622.12 ELR12353.1 - 8.4e-65 218.0 1.0 7.3e-48 162.7 0.0 2.0 1 1 1 2 2 2 2 ERG2 and Sigma1 receptor like protein DUF2183 PF09949.9 ELR12355.1 - 1.2e-28 99.3 0.0 7e-28 96.9 0.0 2.2 3 0 0 3 3 3 1 Uncharacterized conserved protein (DUF2183) LRR_6 PF13516.6 ELR12356.1 - 0.014 15.4 0.2 0.12 12.4 0.0 2.3 2 0 0 2 2 2 0 Leucine Rich repeat Importin_rep_5 PF18816.1 ELR12356.1 - 0.061 13.6 0.0 11 6.4 0.0 2.3 2 0 0 2 2 2 0 Importin repeat LRR_4 PF12799.7 ELR12356.1 - 0.14 12.7 1.4 0.52 10.8 1.4 2.0 1 1 0 1 1 1 0 Leucine Rich repeats (2 copies) LRR_4 PF12799.7 ELR12357.1 - 0.39 11.2 23.7 0.47 10.9 0.9 7.6 5 2 1 7 7 7 0 Leucine Rich repeats (2 copies) ApbA_C PF08546.11 ELR12358.1 - 5.6e-28 97.7 0.0 9.8e-28 96.9 0.0 1.4 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA C terminal ApbA PF02558.16 ELR12358.1 - 2e-21 76.3 0.1 7.8e-14 51.6 0.0 2.3 1 1 1 2 2 2 2 Ketopantoate reductase PanE/ApbA PSD2 PF07624.11 ELR12358.1 - 0.059 13.2 0.2 0.67 9.8 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1585) TP6A_N PF04406.14 ELR12359.1 - 8.5e-24 83.3 0.4 2.3e-23 81.9 0.1 1.9 2 0 0 2 2 2 1 Type IIB DNA topoisomerase PHAT PF09246.10 ELR12359.1 - 0.14 12.0 0.2 1.7 8.5 0.2 2.3 1 1 0 1 1 1 0 PHAT Ras PF00071.22 ELR12360.1 - 1.4e-36 125.5 0.1 1.3e-24 86.6 0.0 2.0 2 0 0 2 2 2 2 Ras family Roc PF08477.13 ELR12360.1 - 1e-07 32.2 0.0 0.0032 17.7 0.0 2.1 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR12360.1 - 0.012 15.1 0.0 0.066 12.7 0.0 1.9 2 0 0 2 2 2 0 ADP-ribosylation factor family RsgA_GTPase PF03193.16 ELR12360.1 - 0.015 15.2 0.0 2.7 7.9 0.0 2.1 2 0 0 2 2 2 0 RsgA GTPase IstB_IS21 PF01695.17 ELR12360.1 - 0.036 13.8 0.1 0.12 12.0 0.0 1.8 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA_16 PF13191.6 ELR12360.1 - 0.13 12.6 0.5 0.2 12.0 0.5 1.7 1 1 0 1 1 1 0 AAA ATPase domain Mito_carr PF00153.27 ELR12361.1 - 8.2e-18 64.1 0.4 1.9e-10 40.5 0.0 3.2 3 0 0 3 3 3 2 Mitochondrial carrier protein UBA PF00627.31 ELR12364.1 - 1.2e-23 82.6 2.1 6.9e-15 54.6 0.1 2.4 2 0 0 2 2 2 2 UBA/TS-N domain XPC-binding PF09280.11 ELR12364.1 - 7.7e-16 57.6 4.6 7.7e-16 57.6 4.6 3.1 2 1 1 3 3 3 1 XPC-binding domain ubiquitin PF00240.23 ELR12364.1 - 3e-13 49.3 0.1 4.7e-13 48.7 0.1 1.3 1 0 0 1 1 1 1 Ubiquitin family Ubiquitin_5 PF18037.1 ELR12364.1 - 9.9e-05 22.6 0.0 0.00021 21.6 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin-like domain CUE PF02845.16 ELR12364.1 - 0.00064 19.4 0.0 0.052 13.3 0.1 2.6 2 0 0 2 2 2 1 CUE domain Rad60-SLD PF11976.8 ELR12364.1 - 0.00069 19.4 0.3 0.0016 18.3 0.1 1.7 2 0 0 2 2 2 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_4 PF18036.1 ELR12364.1 - 0.011 15.8 0.4 0.13 12.4 0.4 2.2 1 1 0 1 1 1 0 Ubiquitin-like domain DUF2407 PF10302.9 ELR12364.1 - 0.029 14.9 0.0 0.058 14.0 0.0 1.4 1 0 0 1 1 1 0 DUF2407 ubiquitin-like domain UBA_3 PF09288.10 ELR12364.1 - 0.058 13.2 0.0 1.1 9.1 0.0 2.4 2 0 0 2 2 2 0 Fungal ubiquitin-associated domain DUF218 PF02698.17 ELR12364.1 - 0.07 13.2 0.1 0.36 10.8 0.0 2.0 2 0 0 2 2 2 0 DUF218 domain UN_NPL4 PF11543.8 ELR12364.1 - 0.073 13.6 0.0 0.15 12.6 0.0 1.5 1 0 0 1 1 1 0 Nuclear pore localisation protein NPL4 YukD PF08817.10 ELR12364.1 - 0.089 13.5 0.1 0.47 11.2 0.0 2.4 2 0 0 2 2 2 0 WXG100 protein secretion system (Wss), protein YukD SAP PF02037.27 ELR12365.1 - 1.9e-10 40.2 0.0 5.2e-10 38.8 0.0 1.8 1 0 0 1 1 1 1 SAP domain F-box-like PF12937.7 ELR12365.1 - 5.7e-06 26.1 0.2 1.1e-05 25.2 0.2 1.4 1 0 0 1 1 1 1 F-box-like DUF4633 PF15464.6 ELR12365.1 - 4 7.6 8.3 9.7 6.4 6.9 2.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4633) PIEZO PF15917.5 ELR12366.1 - 3.7 7.0 12.7 1.7 8.1 0.0 2.2 2 0 0 2 2 2 0 Piezo Presenilin PF01080.17 ELR12367.1 - 7.2 5.3 8.8 10 4.8 8.8 1.1 1 0 0 1 1 1 0 Presenilin HSP70 PF00012.20 ELR12370.1 - 7.6e-242 803.8 12.1 5.9e-240 797.5 12.1 2.0 1 1 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 ELR12370.1 - 2.2e-15 56.3 0.8 3.3e-14 52.5 0.2 2.1 2 0 0 2 2 2 1 MreB/Mbl protein FGGY_C PF02782.16 ELR12370.1 - 0.00065 19.5 0.0 0.0014 18.4 0.0 1.6 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain Hydantoinase_A PF01968.18 ELR12370.1 - 0.0088 15.3 0.1 0.019 14.2 0.1 1.6 1 0 0 1 1 1 1 Hydantoinase/oxoprolinase DDR PF08841.10 ELR12370.1 - 0.01 14.8 0.3 1.3 8.0 0.1 2.4 2 0 0 2 2 2 0 Diol dehydratase reactivase ATPase-like domain Ppx-GppA PF02541.16 ELR12370.1 - 0.11 11.9 1.0 0.19 11.1 0.1 1.8 2 0 0 2 2 2 0 Ppx/GppA phosphatase family DUF3813 PF12758.7 ELR12370.1 - 0.26 11.6 2.7 8.1 6.9 0.1 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3813) Z1 PF10593.9 ELR12370.1 - 0.43 10.1 3.3 0.95 8.9 3.3 1.5 1 0 0 1 1 1 0 Z1 domain TBCA PF02970.16 ELR12370.1 - 3 8.2 9.2 8.4 6.8 9.2 1.7 1 0 0 1 1 1 0 Tubulin binding cofactor A SmpA_OmlA PF04355.13 ELR12372.1 - 0.087 12.6 0.1 0.18 11.6 0.1 1.5 1 0 0 1 1 1 0 SmpA / OmlA family MFS_1 PF07690.16 ELR12373.1 - 1.7e-33 116.0 33.2 3e-19 69.2 15.4 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 ELR12373.1 - 1.9e-09 36.9 12.7 5.6e-07 28.8 1.8 2.4 2 0 0 2 2 2 2 Sugar (and other) transporter MFS_1_like PF12832.7 ELR12373.1 - 0.00071 18.5 7.3 0.06 12.2 0.2 2.7 2 1 0 2 2 2 2 MFS_1 like family OATP PF03137.20 ELR12373.1 - 0.0018 16.6 16.3 0.025 12.9 0.4 3.5 2 1 1 3 3 3 2 Organic Anion Transporter Polypeptide (OATP) family Atrophin-1 PF03154.15 ELR12373.1 - 4.3 5.5 10.3 0.15 10.4 0.4 2.0 2 0 0 2 2 2 0 Atrophin-1 family DUF727 PF05303.12 ELR12374.1 - 2.6e-20 72.4 0.0 3.1e-20 72.2 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF727) Cyclin_N PF00134.23 ELR12375.1 - 3.2e-37 127.1 0.5 1.3e-34 118.7 0.0 3.2 2 1 0 2 2 2 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 ELR12375.1 - 1.9e-33 115.0 0.7 3.7e-33 114.1 0.7 1.5 1 0 0 1 1 1 1 Cyclin, C-terminal domain Dioxygenase_N PF04444.14 ELR12375.1 - 0.12 12.2 0.0 0.35 10.7 0.0 1.7 1 0 0 1 1 1 0 Catechol dioxygenase N terminus COX15-CtaA PF02628.15 ELR12376.1 - 5.1e-101 338.0 11.8 7.9e-101 337.4 11.8 1.3 1 0 0 1 1 1 1 Cytochrome oxidase assembly protein DUF1467 PF07330.12 ELR12376.1 - 3 7.8 8.0 0.6 10.1 0.7 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF1467) SR-25 PF10500.9 ELR12377.1 - 0.46 10.1 13.4 0.39 10.3 5.0 2.2 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein p450 PF00067.22 ELR12378.1 - 6.1e-56 190.1 0.0 4e-53 180.8 0.0 2.0 1 1 1 2 2 2 2 Cytochrome P450 LRR_4 PF12799.7 ELR12380.1 - 3.5e-05 24.1 4.0 2.5 8.6 0.1 7.8 9 2 1 10 10 10 1 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 ELR12380.1 - 0.00092 18.9 1.1 0.29 10.9 0.0 5.0 4 1 0 4 4 4 1 Leucine rich repeat Doppel PF11466.8 ELR12382.1 - 0.31 10.7 1.2 0.58 9.8 1.2 1.5 1 0 0 1 1 1 0 Prion-like protein Doppel Mito_carr PF00153.27 ELR12383.1 - 2.5e-07 30.5 0.0 2.5e-07 30.5 0.0 1.0 1 0 0 1 1 1 1 Mitochondrial carrier protein SUI1 PF01253.22 ELR12384.1 - 1.7e-21 76.5 4.3 2.2e-21 76.2 4.3 1.1 1 0 0 1 1 1 1 Translation initiation factor SUI1 Img2 PF05046.14 ELR12384.1 - 0.015 15.6 0.8 0.025 14.9 0.8 1.4 1 0 0 1 1 1 0 Mitochondrial large subunit ribosomal protein (Img2) SH3_19 PF18597.1 ELR12384.1 - 0.034 14.0 0.1 0.055 13.3 0.1 1.3 1 0 0 1 1 1 0 Myosin X N-terminal SH3 domain Kelch_4 PF13418.6 ELR12385.1 - 3.4e-24 84.6 5.2 9.1e-07 28.8 0.0 5.5 5 0 0 5 5 5 4 Galactose oxidase, central domain Kelch_3 PF13415.6 ELR12385.1 - 6.3e-19 67.8 4.0 1.6e-06 28.2 0.2 6.0 6 0 0 6 6 6 4 Galactose oxidase, central domain Kelch_6 PF13964.6 ELR12385.1 - 8.6e-15 54.4 2.9 0.0068 16.7 0.0 5.5 3 1 2 5 5 5 4 Kelch motif Kelch_1 PF01344.25 ELR12385.1 - 8.9e-12 44.4 5.5 5.2e-05 22.7 1.1 4.3 4 1 0 4 4 4 2 Kelch motif Kelch_2 PF07646.15 ELR12385.1 - 5.6e-11 42.0 10.0 8.2e-05 22.4 1.4 6.3 6 1 0 6 6 6 3 Kelch motif Kelch_5 PF13854.6 ELR12385.1 - 1.4e-07 31.3 1.5 0.065 13.2 0.4 5.6 5 1 0 5 5 5 2 Kelch motif WHH PF14414.6 ELR12385.1 - 0.35 10.8 3.3 0.84 9.5 3.3 1.6 1 0 0 1 1 1 0 A nuclease of the HNH/ENDO VII superfamily with conserved WHH RimK PF08443.11 ELR12386.1 - 6.4e-05 22.6 0.0 0.00026 20.6 0.0 1.8 2 0 0 2 2 2 1 RimK-like ATP-grasp domain GSH-S_ATP PF02955.16 ELR12386.1 - 0.00094 18.6 0.0 0.0014 18.1 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic glutathione synthetase, ATP-grasp domain BTB PF00651.31 ELR12387.1 - 1.2e-20 73.8 0.0 1.2e-17 64.2 0.0 2.6 1 1 1 2 2 2 2 BTB/POZ domain BACK PF07707.15 ELR12387.1 - 1.5e-17 63.6 0.4 5.6e-17 61.7 0.4 1.9 2 0 0 2 2 2 1 BTB And C-terminal Kelch SPRY PF00622.28 ELR12387.1 - 1.1e-05 25.5 0.1 2e-05 24.7 0.1 1.4 1 0 0 1 1 1 1 SPRY domain Laminin_G_3 PF13385.6 ELR12387.1 - 0.047 13.8 0.3 0.094 12.9 0.3 1.4 1 0 0 1 1 1 0 Concanavalin A-like lectin/glucanases superfamily Fib_alpha PF08702.10 ELR12388.1 - 0.064 13.4 0.2 0.085 13.0 0.2 1.1 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family Hc1 PF07432.13 ELR12388.1 - 0.14 12.6 0.1 0.18 12.2 0.1 1.1 1 0 0 1 1 1 0 Histone H1-like protein Hc1 Sugarporin_N PF11471.8 ELR12388.1 - 0.17 11.8 0.3 0.17 11.8 0.3 1.6 2 0 0 2 2 2 0 Maltoporin periplasmic N-terminal extension CLU PF13236.6 ELR12389.1 - 1.2e-43 149.5 0.0 2.8e-43 148.3 0.0 1.7 1 1 0 1 1 1 1 Clustered mitochondria PH PF00169.29 ELR12389.1 - 2.2e-06 28.1 0.0 6e-06 26.7 0.0 1.7 1 0 0 1 1 1 1 PH domain eIF3_p135 PF12807.7 ELR12389.1 - 0.0016 18.5 0.0 0.0016 18.5 0.0 3.5 4 1 0 4 4 4 1 Translation initiation factor eIF3 subunit 135 TPR_17 PF13431.6 ELR12389.1 - 0.0052 17.1 0.5 1 9.9 0.5 3.0 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_1 PF00515.28 ELR12389.1 - 0.033 14.0 0.0 1.7 8.6 0.0 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_2 PF07719.17 ELR12389.1 - 0.066 13.4 0.4 1.1 9.5 0.0 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_14 PF13428.6 ELR12389.1 - 2 9.4 9.4 21 6.3 0.1 4.8 3 1 1 4 4 4 0 Tetratricopeptide repeat Cupin_2 PF07883.11 ELR12390.1 - 1.6e-11 43.8 1.1 4.3e-11 42.4 1.1 1.7 1 0 0 1 1 1 1 Cupin domain 3-HAO PF06052.12 ELR12390.1 - 1.3e-08 34.6 0.2 2.6e-08 33.6 0.2 1.4 1 0 0 1 1 1 1 3-hydroxyanthranilic acid dioxygenase ARD PF03079.14 ELR12390.1 - 1.3e-07 31.9 0.2 2.4e-07 31.1 0.2 1.4 1 0 0 1 1 1 1 ARD/ARD' family FR47 PF08445.10 ELR12390.1 - 1.5e-06 28.1 0.1 6e-06 26.1 0.1 2.0 1 1 0 1 1 1 1 FR47-like protein Cupin_3 PF05899.12 ELR12390.1 - 2.2e-05 24.1 0.1 4.2e-05 23.1 0.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF861) cNMP_binding PF00027.29 ELR12390.1 - 0.00015 21.8 0.0 0.00032 20.7 0.0 1.5 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain Cupin_1 PF00190.22 ELR12390.1 - 0.00038 20.1 0.0 0.0011 18.6 0.0 1.7 2 0 0 2 2 2 1 Cupin Acetyltransf_7 PF13508.7 ELR12390.1 - 0.00044 20.6 0.0 0.0015 18.9 0.0 1.9 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 ELR12390.1 - 0.001 19.3 0.0 0.0023 18.1 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Cupin_7 PF12973.7 ELR12390.1 - 0.0034 17.2 0.4 0.01 15.7 0.4 1.7 1 1 0 1 1 1 1 ChrR Cupin-like domain Acetyltransf_10 PF13673.7 ELR12390.1 - 0.0041 17.1 0.0 0.056 13.4 0.0 2.3 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.7 ELR12390.1 - 0.0046 17.6 0.0 0.0082 16.8 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain AraC_binding PF02311.19 ELR12390.1 - 0.038 13.9 0.1 0.082 12.8 0.1 1.5 1 0 0 1 1 1 0 AraC-like ligand binding domain Acetyltransf_13 PF13880.6 ELR12390.1 - 0.094 12.7 0.0 0.16 12.0 0.0 1.4 1 0 0 1 1 1 0 ESCO1/2 acetyl-transferase Kelch_4 PF13418.6 ELR12391.1 - 1.4e-18 66.6 6.6 0.0006 19.8 0.1 6.6 4 1 1 5 5 5 4 Galactose oxidase, central domain Kelch_3 PF13415.6 ELR12391.1 - 1.6e-15 56.9 0.8 1.7e-06 28.2 0.0 6.4 5 1 1 6 6 6 2 Galactose oxidase, central domain Kelch_1 PF01344.25 ELR12391.1 - 1.7e-09 37.1 2.3 0.00037 20.0 0.1 4.7 5 0 0 5 5 5 2 Kelch motif Kelch_2 PF07646.15 ELR12391.1 - 5.1e-08 32.6 12.7 8.4e-06 25.6 0.2 5.9 7 1 0 7 7 7 1 Kelch motif Kelch_6 PF13964.6 ELR12391.1 - 5.9e-07 29.5 7.8 0.28 11.6 0.1 5.6 3 2 2 5 5 5 3 Kelch motif Kelch_5 PF13854.6 ELR12391.1 - 2.4e-06 27.4 13.7 0.012 15.6 0.5 6.0 6 2 0 6 6 6 2 Kelch motif F-box-like PF12937.7 ELR12391.1 - 0.00039 20.2 0.1 0.00039 20.2 0.1 2.1 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 ELR12391.1 - 0.033 14.1 0.0 0.072 13.0 0.0 1.5 1 0 0 1 1 1 0 F-box domain DEAD PF00270.29 ELR12392.1 - 2e-43 148.2 0.0 3.5e-43 147.4 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ELR12392.1 - 1.9e-26 92.5 0.0 8.3e-26 90.5 0.2 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain GUCT PF08152.12 ELR12392.1 - 1.2e-18 67.2 0.0 2.6e-18 66.1 0.0 1.6 1 0 0 1 1 1 1 GUCT (NUC152) domain CMS1 PF14617.6 ELR12392.1 - 0.00033 20.1 0.1 0.00033 20.1 0.1 2.5 2 0 0 2 2 2 1 U3-containing 90S pre-ribosomal complex subunit LRR_8 PF13855.6 ELR12393.1 - 3.1e-61 203.0 90.4 3e-11 42.9 5.8 7.9 3 2 7 10 10 10 10 Leucine rich repeat LRR_4 PF12799.7 ELR12393.1 - 1e-34 117.9 56.6 8.5e-06 26.0 1.2 10.4 5 4 2 10 10 10 8 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 ELR12393.1 - 9.2e-11 40.8 48.2 3.4 8.6 0.1 14.6 15 1 1 16 16 16 7 Leucine Rich Repeat LRR_9 PF14580.6 ELR12393.1 - 2.9e-05 23.6 25.8 0.00038 20.0 0.9 4.5 2 2 3 5 5 5 3 Leucine-rich repeat DUF4571 PF15137.6 ELR12393.1 - 0.051 13.2 2.1 0.22 11.1 0.3 2.7 2 1 1 3 3 3 0 Domain of unknown function (DUF4571) DEC-1_N PF04625.13 ELR12393.1 - 1.8 7.5 11.8 2.9 6.8 11.8 1.3 1 0 0 1 1 1 0 DEC-1 protein, N-terminal region LRR_6 PF13516.6 ELR12393.1 - 4.1 7.7 59.5 1.4 9.2 0.2 13.7 15 0 0 15 15 15 0 Leucine Rich repeat TatD_DNase PF01026.21 ELR12394.1 - 5.6e-60 202.9 0.0 6.4e-60 202.7 0.0 1.0 1 0 0 1 1 1 1 TatD related DNase Amidohydro_2 PF04909.14 ELR12394.1 - 0.012 15.5 0.2 0.048 13.4 0.2 1.9 1 1 0 1 1 1 0 Amidohydrolase Gemini_AL1_M PF08283.11 ELR12394.1 - 0.052 13.6 0.0 0.093 12.8 0.0 1.3 1 0 0 1 1 1 0 Geminivirus rep protein central domain Dak1 PF02733.17 ELR12395.1 - 1.7e-101 339.2 0.3 2.8e-100 335.2 0.2 2.1 2 0 0 2 2 2 1 Dak1 domain Dak2 PF02734.17 ELR12395.1 - 6.2e-33 114.1 17.3 1.1e-20 74.3 3.0 3.5 2 1 1 3 3 3 2 DAK2 domain Bep_C_terminal PF17841.1 ELR12395.1 - 0.071 13.3 0.3 0.38 11.0 0.3 2.2 1 0 0 1 1 1 0 BID domain of Bartonella effector protein (Bep) PH PF00169.29 ELR12396.1 - 1.8e-41 140.9 6.4 2.1e-21 76.4 0.4 3.5 3 0 0 3 3 3 3 PH domain RhoGAP PF00620.27 ELR12396.1 - 1.6e-37 128.7 0.0 1.1e-36 125.9 0.0 2.3 2 0 0 2 2 2 1 RhoGAP domain RhoGEF PF00621.20 ELR12396.1 - 1.7e-20 74.0 0.4 1.7e-20 74.0 0.4 3.2 3 0 0 3 3 3 1 RhoGEF domain BAR_3 PF16746.5 ELR12396.1 - 3.4e-11 43.3 5.1 3.4e-11 43.3 5.1 3.2 3 0 0 3 3 3 1 BAR domain of APPL family PH_3 PF14593.6 ELR12396.1 - 3.4e-09 36.8 7.6 9.1e-06 25.7 0.0 4.4 5 0 0 5 5 4 2 PH domain PH_11 PF15413.6 ELR12396.1 - 8e-09 35.9 22.6 6.1e-06 26.6 4.7 5.7 3 2 1 4 4 4 2 Pleckstrin homology domain BAR PF03114.18 ELR12396.1 - 7.5e-08 32.3 6.1 7.5e-08 32.3 6.1 2.3 3 0 0 3 3 3 1 BAR domain PH_8 PF15409.6 ELR12396.1 - 9.5e-07 29.0 1.5 0.0012 19.1 0.1 2.6 2 0 0 2 2 2 2 Pleckstrin homology domain PH_13 PF16652.5 ELR12396.1 - 0.0021 17.9 3.1 3.4 7.5 0.8 3.7 3 1 0 3 3 3 2 Pleckstrin homology domain PH_2 PF08458.10 ELR12396.1 - 0.0024 18.2 3.3 0.029 14.7 0.0 3.6 4 0 0 4 4 4 1 Plant pleckstrin homology-like region IQ_SEC7_PH PF16453.5 ELR12396.1 - 0.0088 16.0 2.0 0.63 10.0 0.1 3.0 3 0 0 3 3 3 1 PH domain PH_9 PF15410.6 ELR12396.1 - 0.14 12.5 14.0 2.4 8.6 0.6 5.5 4 2 0 4 4 4 0 Pleckstrin homology domain Ank_2 PF12796.7 ELR12397.1 - 7.3e-36 122.6 8.3 5.5e-09 36.5 0.2 8.2 6 1 2 8 8 8 5 Ankyrin repeats (3 copies) PARP PF00644.20 ELR12397.1 - 4.6e-33 114.5 0.0 1.1e-32 113.2 0.0 1.6 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain Ank_4 PF13637.6 ELR12397.1 - 1.9e-30 104.8 6.0 4.2e-07 30.4 0.1 10.7 7 3 4 11 11 11 7 Ankyrin repeats (many copies) Ank_3 PF13606.6 ELR12397.1 - 8.4e-23 78.0 2.8 0.089 13.4 0.0 12.0 12 0 0 12 12 12 5 Ankyrin repeat Ank PF00023.30 ELR12397.1 - 6.9e-22 76.9 10.7 0.0024 18.2 0.1 9.7 11 0 0 11 11 11 6 Ankyrin repeat Ank_5 PF13857.6 ELR12397.1 - 3.8e-12 46.2 12.4 0.00027 21.2 0.1 9.8 11 0 0 11 11 11 2 Ankyrin repeats (many copies) PARP_reg PF02877.14 ELR12397.1 - 1.8e-07 31.3 0.0 4e-07 30.2 0.0 1.6 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase, regulatory domain WGR PF05406.15 ELR12397.1 - 0.072 13.2 0.2 0.19 11.8 0.2 1.7 1 0 0 1 1 1 0 WGR domain DUF4476 PF14771.6 ELR12398.1 - 6.5e-12 45.6 2.5 1.1e-07 32.0 0.1 2.6 2 1 1 3 3 3 2 Domain of unknown function (DUF4476) VWA_2 PF13519.6 ELR12398.1 - 6.6e-12 46.0 0.4 2.3e-11 44.3 0.1 2.0 2 0 0 2 2 2 1 von Willebrand factor type A domain VWA PF00092.28 ELR12398.1 - 1.6e-09 38.2 0.1 4e-09 37.0 0.1 1.6 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_3 PF13768.6 ELR12398.1 - 1.7e-09 37.8 0.4 5.3e-09 36.2 0.1 2.0 2 1 0 2 2 2 1 von Willebrand factor type A domain mRNA_stabil PF13929.6 ELR12398.1 - 0.059 12.4 0.0 0.092 11.7 0.0 1.3 1 0 0 1 1 1 0 mRNA stabilisation PP2 PF14299.6 ELR12398.1 - 0.12 12.4 0.0 0.52 10.3 0.0 1.9 2 0 0 2 2 2 0 Phloem protein 2 HAUS6_N PF14661.6 ELR12399.1 - 8e-05 22.3 0.0 0.011 15.3 0.0 2.0 2 0 0 2 2 2 2 HAUS augmin-like complex subunit 6 N-terminus Tmemb_40 PF10160.9 ELR12399.1 - 0.027 13.9 1.6 0.03 13.8 1.6 1.1 1 0 0 1 1 1 0 Predicted membrane protein BUD22 PF09073.10 ELR12400.1 - 6.6e-05 22.4 46.2 0.011 15.2 15.0 2.2 2 0 0 2 2 2 2 BUD22 Cwf_Cwc_15 PF04889.12 ELR12400.1 - 0.0024 17.7 14.6 0.0024 17.7 14.6 2.3 2 0 0 2 2 2 1 Cwf15/Cwc15 cell cycle control protein Na_trans_assoc PF06512.13 ELR12400.1 - 0.011 16.0 8.2 0.011 16.0 8.2 2.4 2 0 0 2 2 2 0 Sodium ion transport-associated zf-C5HC2 PF02928.16 ELR12400.1 - 0.097 13.1 1.1 0.23 11.8 0.1 2.1 2 0 0 2 2 2 0 C5HC2 zinc finger zf_ZIC PF18366.1 ELR12400.1 - 0.16 12.1 0.2 0.46 10.6 0.2 1.8 1 0 0 1 1 1 0 Zic proteins zinc finger domain TFIIA PF03153.13 ELR12400.1 - 0.23 11.4 28.0 0.22 11.5 8.1 2.3 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit LAP1C PF05609.12 ELR12400.1 - 3.8 6.5 34.0 0.29 10.2 12.3 2.2 2 0 0 2 2 2 0 Lamina-associated polypeptide 1C (LAP1C) 2OG-FeII_Oxy_3 PF13640.6 ELR12401.1 - 1.1e-10 42.2 0.1 3.3e-10 40.7 0.0 1.7 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily DR2241 PF18069.1 ELR12401.1 - 0.011 15.6 0.1 0.02 14.8 0.1 1.5 1 0 0 1 1 1 0 DR2241 stabilising domain WD40 PF00400.32 ELR12402.1 - 6.7e-34 115.4 9.4 1.2e-08 35.5 0.1 6.5 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ELR12402.1 - 1.3e-15 57.5 0.0 0.00054 20.2 0.0 5.5 3 1 3 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain CSTF1_dimer PF16699.5 ELR12402.1 - 8.6e-11 41.4 0.1 1.4e-10 40.8 0.1 1.4 1 0 0 1 1 1 1 Cleavage stimulation factor subunit 1, dimerisation domain Cytochrom_D1 PF02239.16 ELR12402.1 - 4.6e-05 22.1 0.0 0.0011 17.5 0.0 2.1 1 1 1 2 2 2 1 Cytochrome D1 heme domain VID27 PF08553.10 ELR12402.1 - 8e-05 21.9 0.0 0.0086 15.2 0.0 2.2 1 1 1 2 2 2 2 VID27 C-terminal WD40-like domain eIF2A PF08662.11 ELR12402.1 - 0.00054 19.9 0.0 0.0017 18.3 0.0 1.8 2 1 0 2 2 2 1 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 ELR12402.1 - 0.0024 16.9 0.4 2.1 7.2 0.1 2.6 1 1 0 2 2 2 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ELR12402.1 - 0.017 13.8 0.5 1.1 7.8 0.1 2.6 1 1 2 3 3 3 0 Nucleoporin Nup120/160 WD40_like PF17005.5 ELR12402.1 - 0.14 11.5 0.0 19 4.5 0.0 2.4 2 0 0 2 2 2 0 WD40-like domain VWA_2 PF13519.6 ELR12404.1 - 3.7e-12 46.8 0.7 1.3e-11 45.1 0.2 2.1 2 1 0 2 2 2 1 von Willebrand factor type A domain VWA PF00092.28 ELR12404.1 - 2.3e-10 41.0 0.2 4.6e-10 40.0 0.2 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_3 PF13768.6 ELR12404.1 - 2.7e-10 40.4 0.2 2.2e-09 37.4 0.1 2.2 1 1 1 2 2 2 1 von Willebrand factor type A domain DUF4476 PF14771.6 ELR12404.1 - 5.4e-09 36.2 1.0 2.6e-06 27.6 0.1 2.7 2 1 1 3 3 3 2 Domain of unknown function (DUF4476) PP2 PF14299.6 ELR12404.1 - 0.024 14.7 0.0 0.071 13.1 0.0 1.8 2 0 0 2 2 2 0 Phloem protein 2 Pkinase_Tyr PF07714.17 ELR12408.1 - 6.5e-07 28.9 0.1 1.2e-06 28.1 0.1 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Methyltransf_23 PF13489.6 ELR12408.1 - 0.00067 19.5 0.0 0.0011 18.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ELR12408.1 - 0.00082 20.0 0.0 0.0054 17.4 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 ELR12408.1 - 0.0011 19.6 0.0 0.0025 18.5 0.1 1.7 2 0 0 2 2 2 1 Methyltransferase domain Pkinase PF00069.25 ELR12408.1 - 0.012 15.0 0.0 0.018 14.4 0.0 1.2 1 0 0 1 1 1 0 Protein kinase domain Methyltransf_11 PF08241.12 ELR12408.1 - 0.019 15.6 0.0 0.043 14.5 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain COR PF16095.5 ELR12409.1 - 1.2e-12 48.0 0.0 3.2e-12 46.7 0.0 1.7 1 0 0 1 1 1 1 C-terminal of Roc, COR, domain CNDH2_C PF16858.5 ELR12409.1 - 0.0072 16.2 4.4 0.0072 16.2 4.4 2.3 2 0 0 2 2 2 1 Condensin II complex subunit CAP-H2 or CNDH2, C-term zf-C5HC2 PF02928.16 ELR12409.1 - 0.21 12.0 1.3 0.42 11.1 0.1 2.1 2 0 0 2 2 2 0 C5HC2 zinc finger TFIIA PF03153.13 ELR12409.1 - 0.92 9.4 26.9 0.21 11.5 7.7 2.1 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit BUD22 PF09073.10 ELR12409.1 - 1.1 8.5 48.6 2 7.7 22.5 2.1 2 0 0 2 2 2 0 BUD22 FAM60A PF15396.6 ELR12409.1 - 1.8 8.5 25.4 4.1 7.3 5.9 2.4 2 0 0 2 2 2 0 Protein Family FAM60A Zip PF02535.22 ELR12409.1 - 3.1 6.9 15.9 3.7 6.7 5.2 2.4 2 0 0 2 2 2 0 ZIP Zinc transporter Cwf_Cwc_15 PF04889.12 ELR12409.1 - 3.8 7.2 44.2 0.042 13.6 15.4 2.2 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein BSP_II PF05432.11 ELR12409.1 - 4.1 7.0 46.3 6.4 6.4 27.8 2.3 2 0 0 2 2 2 0 Bone sialoprotein II (BSP-II) PPP4R2 PF09184.11 ELR12409.1 - 7.7 6.0 37.0 0.85 9.2 13.1 2.3 2 0 0 2 2 2 0 PPP4R2 p450 PF00067.22 ELR12410.1 - 4.3e-51 174.1 0.0 5.1e-51 173.9 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 ABC2_membrane PF01061.24 ELR12411.1 - 2e-54 184.2 31.4 8.8e-38 129.8 18.1 2.5 2 0 0 2 2 2 2 ABC-2 type transporter PDR_assoc PF08370.11 ELR12411.1 - 0.0025 17.5 2.7 0.011 15.4 0.1 3.2 3 0 0 3 3 3 1 Plant PDR ABC transporter associated ABC2_membrane_3 PF12698.7 ELR12411.1 - 0.019 14.1 29.0 0.16 11.0 1.2 2.6 2 1 0 2 2 2 0 ABC-2 family transporter protein Spt5_N PF11942.8 ELR12411.1 - 0.27 12.3 3.7 0.43 11.6 3.7 1.2 1 0 0 1 1 1 0 Spt5 transcription elongation factor, acidic N-terminal PDR_CDR PF06422.12 ELR12411.1 - 0.44 10.5 4.9 4.6 7.2 0.0 3.3 3 0 0 3 3 3 0 CDR ABC transporter DUF4136 PF13590.6 ELR12413.1 - 0.072 13.7 0.1 0.086 13.4 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4136) PAPA-1 PF04795.12 ELR12414.1 - 0.15 12.8 0.1 0.15 12.8 0.1 2.7 2 1 0 2 2 2 0 PAPA-1-like conserved region Rgp1 PF08737.10 ELR12415.1 - 3.7e-33 115.3 0.1 3.4e-23 82.5 0.0 2.1 2 0 0 2 2 2 2 Rgp1 Arrestin_C PF02752.22 ELR12415.1 - 0.00035 21.0 0.0 0.072 13.5 0.0 2.5 2 1 0 2 2 2 2 Arrestin (or S-antigen), C-terminal domain Arrestin_N PF00339.29 ELR12415.1 - 0.042 13.9 0.0 0.11 12.5 0.0 1.7 1 0 0 1 1 1 0 Arrestin (or S-antigen), N-terminal domain SatD PF16264.5 ELR12415.1 - 0.24 11.0 0.0 0.37 10.4 0.0 1.1 1 0 0 1 1 1 0 SatD family (SatD) RhoGAP PF00620.27 ELR12416.1 - 1.1e-37 129.2 0.0 2e-37 128.3 0.0 1.4 1 0 0 1 1 1 1 RhoGAP domain RhoGEF PF00621.20 ELR12416.1 - 1.2e-10 42.0 0.6 4e-10 40.2 0.2 2.1 2 0 0 2 2 2 1 RhoGEF domain Big_9 PF17963.1 ELR12417.1 - 3.1e-24 85.5 4.5 3.1e-08 34.2 0.0 5.5 5 0 0 5 5 5 5 Bacterial Ig domain Cadherin_5 PF17892.1 ELR12417.1 - 6.2e-11 42.1 0.3 2.9e-05 24.0 0.0 4.6 4 1 0 4 4 4 2 Cadherin-like domain Cadherin_4 PF17803.1 ELR12417.1 - 0.032 14.9 9.2 21 5.8 0.2 4.6 5 0 0 5 5 5 0 Bacterial cadherin-like domain Syntaxin-6_N PF09177.11 ELR12417.1 - 1.1 9.8 8.2 13 6.5 0.8 2.7 2 0 0 2 2 2 0 Syntaxin 6, N-terminal WD40 PF00400.32 ELR12418.1 - 1.2e-11 44.9 0.6 0.042 14.7 0.3 5.9 6 0 0 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ELR12418.1 - 1.1e-07 32.1 0.0 0.26 11.6 0.0 4.5 4 0 0 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Hira PF07569.11 ELR12418.1 - 0.049 13.4 1.1 0.23 11.2 0.0 2.6 3 0 0 3 3 3 0 TUP1-like enhancer of split Vac_Fusion PF02346.16 ELR12418.1 - 0.15 11.7 3.4 0.26 11.0 2.0 2.0 2 0 0 2 2 2 0 Chordopoxvirus multifunctional envelope protein A27 RhoGEF PF00621.20 ELR12419.1 - 2.7e-15 57.1 0.2 6.6e-15 55.8 0.2 1.7 1 0 0 1 1 1 1 RhoGEF domain PH PF00169.29 ELR12419.1 - 1.8e-05 25.2 0.1 9.4e-05 22.9 0.1 2.3 1 1 0 1 1 1 1 PH domain CDC45 PF02724.14 ELR12419.1 - 0.00019 19.9 30.6 0.0016 16.8 7.7 2.1 2 0 0 2 2 2 2 CDC45-like protein TFIIF_alpha PF05793.12 ELR12419.1 - 0.0014 17.4 39.8 0.0045 15.6 17.4 2.2 2 0 0 2 2 2 2 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) CCSAP PF15748.5 ELR12419.1 - 0.025 14.7 39.3 0.044 14.0 21.7 2.4 2 0 0 2 2 2 0 Centriole, cilia and spindle-associated Nop14 PF04147.12 ELR12419.1 - 0.053 11.7 37.1 0.34 9.1 10.7 2.1 2 0 0 2 2 2 0 Nop14-like family RR_TM4-6 PF06459.12 ELR12419.1 - 0.48 10.2 44.4 1.4 8.7 10.3 2.2 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 DUF4637 PF15470.6 ELR12419.1 - 0.58 9.9 33.4 0.025 14.3 12.7 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4637) DUF2052 PF09747.9 ELR12419.1 - 0.77 9.9 40.0 1.6 8.8 8.6 2.4 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) TAF4 PF05236.14 ELR12419.1 - 0.95 9.1 27.9 1.7 8.3 12.0 2.6 2 0 0 2 2 2 0 Transcription initiation factor TFIID component TAF4 family DUF3807 PF12720.7 ELR12419.1 - 1.6 9.0 40.3 1.7 8.9 9.9 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3807) Vfa1 PF08432.10 ELR12419.1 - 2 8.7 44.0 1.8 8.9 8.6 2.7 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 RPN2_C PF18004.1 ELR12419.1 - 3.5 7.5 44.4 3.5 7.5 10.8 2.5 2 0 0 2 2 2 0 26S proteasome regulatory subunit RPN2 C-terminal domain Med19 PF10278.9 ELR12419.1 - 4.2 7.3 43.2 0.23 11.4 21.7 2.3 2 0 0 2 2 2 0 Mediator of RNA pol II transcription subunit 19 CDC27 PF09507.10 ELR12419.1 - 5.6 6.2 49.6 2 7.7 13.3 2.2 2 0 0 2 2 2 0 DNA polymerase subunit Cdc27 Presenilin PF01080.17 ELR12419.1 - 6.6 5.4 33.8 2.5 6.8 17.9 2.2 2 0 0 2 2 2 0 Presenilin Merozoite_SPAM PF07133.11 ELR12419.1 - 8.7 6.3 54.7 1.4 8.9 27.9 2.3 2 0 0 2 2 2 0 Merozoite surface protein (SPAM) CAF-1_p150 PF11600.8 ELR12419.1 - 9.8 5.8 62.5 4.6 6.9 17.6 2.5 2 0 0 2 2 2 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal HTH_31 PF13560.6 ELR12421.1 - 0.077 13.4 0.2 0.46 10.9 0.0 2.5 2 0 0 2 2 2 0 Helix-turn-helix domain V_ATPase_I_N PF18670.1 ELR12421.1 - 0.087 13.2 0.2 0.2 12.1 0.2 1.5 1 0 0 1 1 1 0 V-type ATPase subunit I, N-terminal domain RE_EcoO109I PF14511.6 ELR12422.1 - 0.03 13.9 0.0 0.044 13.4 0.0 1.1 1 0 0 1 1 1 0 Type II restriction endonuclease EcoO109I Host_attach PF10116.9 ELR12422.1 - 0.56 10.8 3.8 0.97 10.0 3.8 1.3 1 0 0 1 1 1 0 Protein required for attachment to host cells LIM PF00412.22 ELR12423.1 - 4.8e-35 119.6 33.9 2.5e-12 46.8 9.6 3.2 3 0 0 3 3 3 3 LIM domain RA PF00788.23 ELR12423.1 - 0.0039 17.8 0.0 0.0097 16.5 0.0 1.6 2 0 0 2 2 2 1 Ras association (RalGDS/AF-6) domain HA PF03457.14 ELR12424.1 - 4.3e-26 91.0 10.6 2.2e-16 60.0 1.0 3.2 2 1 0 2 2 2 2 Helicase associated domain Sporozoite_P67 PF05642.11 ELR12424.1 - 0.016 13.3 0.4 0.023 12.8 0.4 1.2 1 0 0 1 1 1 0 Sporozoite P67 surface antigen DUF3446 PF11928.8 ELR12424.1 - 0.077 13.3 2.0 0.17 12.2 2.0 1.5 1 0 0 1 1 1 0 Early growth response N-terminal domain PIF1 PF05970.14 ELR12426.1 - 1.7e-28 99.9 0.0 2.2e-25 89.6 0.0 2.3 1 1 0 1 1 1 1 PIF1-like helicase AAA_30 PF13604.6 ELR12426.1 - 6.5e-10 39.0 0.0 8.9e-09 35.3 0.0 2.2 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.6 ELR12426.1 - 0.014 15.8 0.0 0.046 14.1 0.0 2.0 1 1 0 1 1 1 0 AAA domain CDC45 PF02724.14 ELR12426.1 - 0.057 11.7 0.5 0.082 11.2 0.5 1.1 1 0 0 1 1 1 0 CDC45-like protein RMI1_N PF08585.12 ELR12426.1 - 0.093 12.5 0.3 0.16 11.7 0.3 1.3 1 0 0 1 1 1 0 RecQ mediated genome instability protein RsgA_GTPase PF03193.16 ELR12426.1 - 0.14 12.0 0.1 0.4 10.6 0.0 1.7 2 0 0 2 2 2 0 RsgA GTPase DUF1930 PF09122.10 ELR12427.1 - 0.11 12.5 0.0 0.19 11.8 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1930) XPG_I PF00867.18 ELR12428.1 - 1.9e-17 63.4 0.0 5e-17 62.0 0.0 1.8 1 0 0 1 1 1 1 XPG I-region XPG_N PF00752.17 ELR12428.1 - 1.3e-10 41.6 0.0 3.6e-10 40.2 0.0 1.7 1 0 0 1 1 1 1 XPG N-terminal domain XRN_N PF03159.18 ELR12428.1 - 0.0042 16.6 0.1 0.0085 15.6 0.1 1.6 1 0 0 1 1 1 1 XRN 5'-3' exonuclease N-terminus HD PF01966.22 ELR12429.1 - 1.6e-10 41.2 1.8 1.8e-10 41.1 0.2 1.9 2 0 0 2 2 2 1 HD domain PDEase_I PF00233.19 ELR12429.1 - 0.0048 16.6 0.1 0.011 15.5 0.1 1.5 1 1 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase RNase_T PF00929.24 ELR12432.1 - 0.013 16.0 0.0 2.1 8.8 0.0 2.2 2 0 0 2 2 2 0 Exonuclease G0-G1_switch_2 PF15103.6 ELR12432.1 - 0.057 13.8 0.0 0.11 13.0 0.0 1.3 1 0 0 1 1 1 0 G0/G1 switch protein 2 2OG-FeII_Oxy_2 PF13532.6 ELR12433.1 - 6.3e-21 75.5 0.0 7.6e-21 75.2 0.0 1.0 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily LapA_dom PF06305.11 ELR12434.1 - 0.019 14.8 0.1 0.019 14.8 0.1 1.9 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain RIC3 PF15361.6 ELR12434.1 - 0.021 15.2 2.1 0.045 14.1 2.1 1.5 1 1 0 1 1 1 0 Resistance to inhibitors of cholinesterase homologue 3 DUF4834 PF16118.5 ELR12434.1 - 0.037 15.0 1.8 0.073 14.0 1.5 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4834) DUF3435 PF11917.8 ELR12434.1 - 0.041 12.8 0.6 0.057 12.4 0.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3435) CD34_antigen PF06365.12 ELR12434.1 - 0.042 13.4 0.1 0.059 12.9 0.1 1.2 1 0 0 1 1 1 0 CD34/Podocalyxin family Syndecan PF01034.20 ELR12434.1 - 0.099 12.6 2.3 0.19 11.7 2.3 1.4 1 0 0 1 1 1 0 Syndecan domain CrgA PF06781.12 ELR12434.1 - 0.19 11.8 0.1 0.19 11.8 0.1 1.9 2 0 0 2 2 2 0 Cell division protein CrgA O-ag_pol_Wzy PF14296.6 ELR12434.1 - 0.24 10.0 0.8 0.32 9.6 0.8 1.1 1 0 0 1 1 1 0 O-antigen polysaccharide polymerase Wzy DUF4366 PF14283.6 ELR12434.1 - 0.66 10.0 5.4 0.15 12.1 0.4 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4366) DUF5345 PF17280.2 ELR12434.1 - 1.4 8.9 5.8 6.8 6.7 1.5 2.4 2 0 0 2 2 2 0 Family of unknown function (DUF5345) Filo_VP35 PF02097.15 ELR12435.1 - 0.0006 19.0 0.0 0.00076 18.6 0.0 1.2 1 0 0 1 1 1 1 Filoviridae VP35 DUF1854 PF08909.11 ELR12435.1 - 0.14 11.9 1.0 9.2 6.1 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF1854) mRNA_cap_enzyme PF01331.19 ELR12436.1 - 3.9e-17 62.7 0.0 4.9e-12 46.1 0.0 2.2 1 1 1 2 2 2 2 mRNA capping enzyme, catalytic domain HTH_56 PF18662.1 ELR12438.1 - 0.04 14.0 0.0 1.1 9.3 0.0 2.4 2 0 0 2 2 2 0 Cch helix turn helix domain FG-GAP PF01839.23 ELR12439.1 - 1.4e-05 25.1 0.1 2.5e-05 24.3 0.1 1.4 1 0 0 1 1 1 1 FG-GAP repeat VCBS PF13517.6 ELR12439.1 - 0.0068 17.0 0.0 0.015 15.8 0.0 1.6 1 0 0 1 1 1 1 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella TcdB_toxin_midN PF12256.8 ELR12439.1 - 0.029 13.7 0.0 0.05 13.0 0.0 1.2 1 0 0 1 1 1 0 Insecticide toxin TcdB middle/N-terminal region Sprouty PF05210.13 ELR12439.1 - 0.24 11.8 13.9 0.92 9.9 5.5 2.7 2 0 0 2 2 2 0 Sprouty protein (Spry) AAA_23 PF13476.6 ELR12440.1 - 0.0012 19.4 12.2 0.0016 19.0 12.2 1.3 1 0 0 1 1 1 1 AAA domain EOS1 PF12326.8 ELR12440.1 - 0.0056 16.6 1.7 0.007 16.3 1.7 1.4 1 0 0 1 1 1 1 N-glycosylation protein SpoIIP PF07454.11 ELR12440.1 - 0.0058 16.1 17.5 0.011 15.2 17.5 1.4 1 0 0 1 1 1 1 Stage II sporulation protein P (SpoIIP) GREB1 PF15782.5 ELR12440.1 - 0.021 12.0 13.5 0.025 11.7 13.5 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer FAM91_C PF14648.6 ELR12440.1 - 0.041 12.7 3.0 0.051 12.4 3.0 1.2 1 0 0 1 1 1 0 FAM91 C-terminus DUF935 PF06074.12 ELR12440.1 - 0.052 12.3 14.3 0.076 11.7 14.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF935) SID-1_RNA_chan PF13965.6 ELR12440.1 - 0.06 11.8 3.8 0.073 11.5 3.8 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 DUF3292 PF11696.8 ELR12440.1 - 0.099 11.0 12.7 0.15 10.4 12.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3292) SLC12 PF03522.15 ELR12440.1 - 0.13 11.2 16.3 0.2 10.6 16.3 1.2 1 0 0 1 1 1 0 Solute carrier family 12 Borrelia_P83 PF05262.11 ELR12440.1 - 0.16 10.4 16.2 0.21 10.0 16.2 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein MDM10 PF12519.8 ELR12440.1 - 0.33 9.8 14.5 0.47 9.3 14.5 1.1 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 PPL5 PF18168.1 ELR12440.1 - 0.41 9.9 15.2 0.65 9.2 15.2 1.2 1 0 0 1 1 1 0 Prim-pol family 5 DUF2126 PF09899.9 ELR12440.1 - 0.54 8.3 17.2 2.6 6.0 17.1 1.8 2 0 0 2 2 2 0 Putative amidoligase enzyme (DUF2126) PRP1_N PF06424.12 ELR12440.1 - 0.65 10.4 24.8 3.4 8.1 2.3 2.4 2 0 0 2 2 2 0 PRP1 splicing factor, N-terminal DUF1644 PF07800.12 ELR12440.1 - 0.89 9.6 10.8 2.1 8.4 10.8 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1644) CPSF100_C PF13299.6 ELR12440.1 - 0.98 9.6 18.1 0.069 13.3 13.1 1.6 2 0 0 2 2 1 0 Cleavage and polyadenylation factor 2 C-terminal FYDLN_acid PF09538.10 ELR12440.1 - 1.1 10.0 21.1 0.4 11.4 9.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (FYDLN_acid) Endostatin PF06482.11 ELR12440.1 - 1.3 8.5 22.9 0.1 12.1 18.2 1.5 2 0 0 2 2 1 0 Collagenase NC10 and Endostatin Presenilin PF01080.17 ELR12440.1 - 1.4 7.6 26.9 0.04 12.7 20.6 1.4 2 0 0 2 2 2 0 Presenilin Sec62 PF03839.16 ELR12440.1 - 1.8 8.0 15.1 3.1 7.3 15.1 1.3 1 0 0 1 1 1 0 Translocation protein Sec62 DUF4407 PF14362.6 ELR12440.1 - 1.9 7.7 22.4 3.7 6.8 22.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) eIF-3_zeta PF05091.12 ELR12440.1 - 2 7.3 29.1 3 6.7 29.1 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) EIIBC-GUT_N PF03612.14 ELR12440.1 - 2 8.1 16.4 4.4 7.0 16.4 1.6 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus TRAP_alpha PF03896.16 ELR12440.1 - 2 7.5 15.4 5.3 6.2 8.6 2.1 2 0 0 2 2 2 0 Translocon-associated protein (TRAP), alpha subunit LMBR1 PF04791.16 ELR12440.1 - 2.4 6.9 7.0 2.8 6.7 7.0 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein PA26 PF04636.13 ELR12440.1 - 2.5 6.9 13.0 3.8 6.3 13.0 1.2 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) MMU163 PF17119.5 ELR12440.1 - 3.5 6.7 8.4 5.9 6.0 8.4 1.4 1 0 0 1 1 1 0 Mitochondrial protein up-regulated during meiosis PTPRCAP PF15713.5 ELR12440.1 - 3.6 7.9 30.5 0.2 11.9 17.7 2.3 2 0 0 2 2 2 0 Protein tyrosine phosphatase receptor type C-associated GNAT_acetyltr_2 PF13718.6 ELR12440.1 - 4.1 6.7 12.0 7.2 5.9 12.0 1.3 1 0 0 1 1 1 0 GNAT acetyltransferase 2 Eapp_C PF10238.9 ELR12440.1 - 4.3 7.4 23.3 9.8 6.2 23.3 1.5 1 0 0 1 1 1 0 E2F-associated phosphoprotein XRN_M PF17846.1 ELR12440.1 - 5 6.0 13.1 7.2 5.4 13.1 1.2 1 0 0 1 1 1 0 Xrn1 helical domain Pet20 PF08692.10 ELR12440.1 - 5.2 7.8 9.0 11 6.8 9.0 1.5 1 0 0 1 1 1 0 Mitochondrial protein Pet20 CCSAP PF15748.5 ELR12440.1 - 5.3 7.1 27.7 0.09 12.9 18.4 2.3 2 1 0 2 2 2 0 Centriole, cilia and spindle-associated DUF913 PF06025.12 ELR12440.1 - 6.5 5.6 17.5 0.14 11.1 10.8 1.5 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) RR_TM4-6 PF06459.12 ELR12440.1 - 6.7 6.4 24.7 0.42 10.4 19.2 1.6 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 Peptidase_S64 PF08192.11 ELR12440.1 - 7.6 4.9 18.2 13 4.2 18.2 1.3 1 0 0 1 1 1 0 Peptidase family S64 NARP1 PF12569.8 ELR12440.1 - 7.6 5.3 19.4 11 4.8 19.4 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 ALMT PF11744.8 ELR12440.1 - 7.7 5.2 17.2 11 4.8 17.2 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Bul1_N PF04425.12 ELR12440.1 - 8.5 5.0 17.3 12 4.5 17.3 1.1 1 0 0 1 1 1 0 Bul1 N terminus Velvet PF11754.8 ELR12440.1 - 9.1 6.1 27.7 0.14 12.1 19.4 1.8 1 1 1 2 2 1 0 Velvet factor Gti1_Pac2 PF09729.9 ELR12440.1 - 9.4 6.3 19.8 21 5.1 19.8 1.5 1 0 0 1 1 1 0 Gti1/Pac2 family MCD PF05292.11 ELR12440.1 - 9.5 5.7 11.2 14 5.1 11.2 1.2 1 0 0 1 1 1 0 Malonyl-CoA decarboxylase C-terminal domain CUB PF00431.20 ELR12443.1 - 0.13 12.6 0.0 0.43 11.0 0.0 1.7 2 0 0 2 2 2 0 CUB domain AAA_33 PF13671.6 ELR12446.1 - 0.026 14.7 0.0 0.032 14.4 0.0 1.3 1 0 0 1 1 1 0 AAA domain SRP54 PF00448.22 ELR12446.1 - 0.032 13.9 0.2 0.05 13.2 0.2 1.3 1 1 0 1 1 1 0 SRP54-type protein, GTPase domain ATP_bind_1 PF03029.17 ELR12446.1 - 0.088 12.6 0.2 0.13 12.0 0.2 1.2 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein AAA_22 PF13401.6 ELR12446.1 - 0.17 12.2 0.0 0.24 11.7 0.0 1.3 1 0 0 1 1 1 0 AAA domain DLIC PF05783.11 ELR12446.1 - 0.17 10.7 0.0 0.22 10.3 0.0 1.2 1 0 0 1 1 1 0 Dynein light intermediate chain (DLIC) ubiquitin PF00240.23 ELR12448.1 - 9.1e-06 25.3 0.0 0.023 14.4 0.0 3.3 3 0 0 3 3 3 2 Ubiquitin family Rad60-SLD PF11976.8 ELR12448.1 - 0.0079 16.0 0.0 18 5.3 0.0 3.3 3 0 0 3 3 3 2 Ubiquitin-2 like Rad60 SUMO-like YukD PF08817.10 ELR12448.1 - 0.17 12.6 0.2 12 6.7 0.0 2.7 2 1 0 2 2 2 0 WXG100 protein secretion system (Wss), protein YukD 2OG-FeII_Oxy_2 PF13532.6 ELR12449.1 - 2.1e-30 106.4 0.0 2.4e-30 106.2 0.0 1.0 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily FTO_NTD PF12933.7 ELR12449.1 - 1.6e-05 24.4 0.7 0.3 10.3 0.0 3.1 1 1 2 3 3 3 3 FTO catalytic domain 2OG-FeII_Oxy PF03171.20 ELR12449.1 - 0.031 14.7 0.0 0.049 14.1 0.0 1.4 1 0 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily Bep_C_terminal PF17841.1 ELR12450.1 - 0.00048 20.3 0.9 0.00084 19.5 0.1 1.8 2 0 0 2 2 2 1 BID domain of Bartonella effector protein (Bep) BCAS2 PF05700.11 ELR12450.1 - 0.0016 18.2 1.9 0.24 11.1 1.1 2.1 2 0 0 2 2 2 2 Breast carcinoma amplified sequence 2 (BCAS2) Spc7 PF08317.11 ELR12450.1 - 0.049 12.5 1.0 0.07 12.0 1.0 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein ATG16 PF08614.11 ELR12450.1 - 0.11 12.7 2.0 0.2 11.9 2.0 1.4 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) KASH_CCD PF14662.6 ELR12450.1 - 0.14 12.0 0.6 0.2 11.5 0.6 1.3 1 0 0 1 1 1 0 Coiled-coil region of CCDC155 or KASH DUF2407_C PF13373.6 ELR12450.1 - 0.14 12.3 0.1 0.28 11.3 0.1 1.4 1 0 0 1 1 1 0 DUF2407 C-terminal domain BshC PF10079.9 ELR12450.1 - 0.17 10.6 0.5 0.25 10.0 0.5 1.2 1 0 0 1 1 1 0 Bacillithiol biosynthesis BshC ABC_tran_CTD PF16326.5 ELR12450.1 - 0.32 11.3 4.5 1.1 9.6 3.2 2.2 1 1 1 2 2 2 0 ABC transporter C-terminal domain EspB PF05802.11 ELR12450.1 - 1.5 8.7 4.6 3.3 7.7 1.5 2.1 2 0 0 2 2 2 0 Enterobacterial EspB protein SprT-like PF10263.9 ELR12451.1 - 1.6e-09 37.6 0.0 4.6e-09 36.1 0.0 1.7 2 0 0 2 2 2 1 SprT-like family Orn_Arg_deC_N PF02784.16 ELR12452.1 - 0.017 14.5 0.0 0.02 14.2 0.0 1.2 1 0 0 1 1 1 0 Pyridoxal-dependent decarboxylase, pyridoxal binding domain DNA_methylase PF00145.17 ELR12453.1 - 4.2e-48 164.4 0.0 1.9e-33 116.3 0.0 2.9 2 1 0 2 2 2 2 C-5 cytosine-specific DNA methylase Insulin PF00049.18 ELR12454.1 - 0.2 12.7 2.2 0.24 12.4 2.2 1.2 1 0 0 1 1 1 0 Insulin/IGF/Relaxin family Sec15 PF04091.12 ELR12456.1 - 7.7e-18 65.0 0.0 7.9e-16 58.3 0.0 2.1 1 1 1 2 2 2 2 Exocyst complex subunit Sec15-like DUF3613 PF12266.8 ELR12456.1 - 0.0091 15.8 0.0 0.16 11.8 0.0 2.5 3 0 0 3 3 3 1 Protein of unknown function (DUF3613) Ion_trans_2 PF07885.16 ELR12458.1 - 0.0054 16.7 0.3 0.0077 16.2 0.3 1.2 1 0 0 1 1 1 1 Ion channel 4HBT_2 PF13279.6 ELR12458.1 - 0.089 13.3 0.0 0.43 11.1 0.0 1.8 2 0 0 2 2 2 0 Thioesterase-like superfamily MFS_1 PF07690.16 ELR12459.1 - 1.1e-20 73.8 40.8 1.7e-14 53.6 20.1 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily PalH PF08733.10 ELR12459.1 - 4.4 6.2 12.0 3.1 6.7 9.0 2.1 1 1 0 2 2 2 0 PalH/RIM21 DUF3810 PF12725.7 ELR12459.1 - 9.9 5.4 9.9 0.77 9.1 4.7 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3810) TLD PF07534.16 ELR12460.1 - 4.4e-07 30.2 0.0 0.0026 18.0 0.0 2.2 2 0 0 2 2 2 2 TLD CDC45 PF02724.14 ELR12460.1 - 0.025 12.9 13.7 0.033 12.5 13.7 1.1 1 0 0 1 1 1 0 CDC45-like protein MRP-S31 PF15433.6 ELR12460.1 - 0.13 11.9 6.1 0.2 11.3 6.1 1.2 1 0 0 1 1 1 0 Mitochondrial 28S ribosomal protein S31 SDA1 PF05285.12 ELR12460.1 - 1.4 8.2 23.2 2.7 7.3 23.2 1.4 1 0 0 1 1 1 0 SDA1 PBP1_TM PF14812.6 ELR12461.1 - 0.68 10.4 10.7 1.8 9.0 2.4 2.4 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DNA_pol_phi PF04931.13 ELR12461.1 - 1.8 6.5 5.0 2.9 5.9 5.0 1.3 1 0 0 1 1 1 0 DNA polymerase phi ASC PF00858.24 ELR12462.1 - 0.0039 16.2 0.2 2.4 7.0 0.0 2.4 2 0 0 2 2 2 2 Amiloride-sensitive sodium channel Cwf_Cwc_15 PF04889.12 ELR12462.1 - 0.53 10.0 9.6 0.84 9.3 9.6 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein CDC45 PF02724.14 ELR12462.1 - 0.89 7.8 5.0 1.2 7.3 5.0 1.1 1 0 0 1 1 1 0 CDC45-like protein Tub_N PF16322.5 ELR12462.1 - 1.2 9.5 6.5 3.1 8.2 6.5 1.6 1 0 0 1 1 1 0 Tubby N-terminal TFIIF_alpha PF05793.12 ELR12462.1 - 8.5 4.8 16.2 12 4.4 16.2 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) PPP4R2 PF09184.11 ELR12462.1 - 9.5 5.7 9.6 15 5.1 9.6 1.2 1 0 0 1 1 1 0 PPP4R2 MBOAT PF03062.19 ELR12463.1 - 7.4e-25 88.0 1.6 7.4e-25 88.0 1.6 2.9 3 0 0 3 3 3 2 MBOAT, membrane-bound O-acyltransferase family Sulfatase PF00884.23 ELR12463.1 - 0.0019 17.7 0.0 0.0032 16.9 0.0 1.2 1 0 0 1 1 1 1 Sulfatase NOA36 PF06524.12 ELR12463.1 - 9.4 5.5 6.6 16 4.7 6.6 1.3 1 0 0 1 1 1 0 NOA36 protein Kinesin PF00225.23 ELR12465.1 - 5.4e-55 186.6 0.0 6.5e-55 186.4 0.0 1.0 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 ELR12465.1 - 5.2e-20 71.9 0.0 7.4e-20 71.4 0.0 1.2 1 0 0 1 1 1 1 Microtubule binding Bac_DnaA PF00308.18 ELR12465.1 - 0.046 13.5 0.0 0.063 13.1 0.0 1.2 1 0 0 1 1 1 0 Bacterial dnaA protein AdoHcyase_NAD PF00670.21 ELR12465.1 - 0.11 12.6 0.4 16 5.6 0.1 2.2 2 0 0 2 2 2 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain Usp PF00582.26 ELR12466.1 - 1e-20 74.7 0.9 4.4e-16 59.7 0.2 2.1 1 1 1 2 2 2 2 Universal stress protein family DNA_photolyase PF00875.18 ELR12466.1 - 0.082 12.9 0.0 0.27 11.2 0.0 1.6 1 1 0 2 2 2 0 DNA photolyase Nitro_FeMo-Co PF02579.17 ELR12466.1 - 0.13 12.6 0.1 0.18 12.1 0.1 1.4 1 0 0 1 1 1 0 Dinitrogenase iron-molybdenum cofactor HMMR_C PF15908.5 ELR12467.1 - 4.4e-07 30.3 17.5 4.4e-07 30.3 17.5 5.3 1 1 2 5 5 5 1 Hyaluronan mediated motility receptor C-terminal DUF4200 PF13863.6 ELR12467.1 - 0.016 15.6 24.9 0.016 15.6 24.9 8.7 2 2 5 8 8 8 0 Domain of unknown function (DUF4200) Nup54_57_C PF18570.1 ELR12467.1 - 0.019 14.5 9.0 0.95 9.1 2.1 5.4 4 0 0 4 4 4 0 NUP57/Nup54 C-terminal domain Laminin_G_2 PF02210.24 ELR12467.1 - 0.02 15.5 1.1 1.8 9.2 0.2 2.6 2 0 0 2 2 2 0 Laminin G domain SlyX PF04102.12 ELR12467.1 - 0.028 15.0 1.2 0.028 15.0 1.2 10.9 3 3 7 10 10 10 0 SlyX Kinesin PF00225.23 ELR12468.1 - 8.7e-77 258.3 0.6 3.5e-76 256.3 0.6 2.1 1 0 0 1 1 1 1 Kinesin motor domain HMMR_C PF15908.5 ELR12468.1 - 2.6e-07 31.1 14.9 2.6e-07 31.1 14.9 7.1 4 3 4 8 8 8 1 Hyaluronan mediated motility receptor C-terminal Imm70 PF15601.6 ELR12468.1 - 0.7 9.4 2.7 16 5.1 0.1 3.6 3 0 0 3 3 3 0 Immunity protein 70 Nup54_57_C PF18570.1 ELR12468.1 - 1.3 8.7 9.5 2.4 7.8 2.1 4.2 4 0 0 4 4 4 0 NUP57/Nup54 C-terminal domain Glyco_transf_15 PF01793.16 ELR12468.1 - 7.5 5.7 8.1 0.22 10.7 1.2 1.9 2 0 0 2 2 2 0 Glycolipid 2-alpha-mannosyltransferase DOPA_dioxygen PF08883.11 ELR12469.1 - 5.1e-39 132.8 0.0 5.8e-39 132.6 0.0 1.0 1 0 0 1 1 1 1 Dopa 4,5-dioxygenase family Rdx PF10262.9 ELR12469.1 - 0.0038 17.4 0.0 0.0041 17.3 0.0 1.2 1 0 0 1 1 1 1 Rdx family MIase PF02426.16 ELR12469.1 - 0.13 12.4 0.0 0.21 11.8 0.0 1.3 1 0 0 1 1 1 0 Muconolactone delta-isomerase PAPA-1 PF04795.12 ELR12470.1 - 6.8e-08 33.2 11.8 6.8e-08 33.2 11.8 4.6 2 2 0 2 2 2 1 PAPA-1-like conserved region SEP PF08059.13 ELR12471.1 - 5.2e-25 87.8 0.0 1.4e-24 86.5 0.0 1.8 1 0 0 1 1 1 1 SEP domain UBX PF00789.20 ELR12471.1 - 1e-17 64.1 0.0 1.8e-17 63.3 0.0 1.5 1 0 0 1 1 1 1 UBX domain UBA_4 PF14555.6 ELR12471.1 - 1.2e-12 47.4 0.1 1.9e-12 46.8 0.1 1.3 1 0 0 1 1 1 1 UBA-like domain TAP_C PF03943.13 ELR12471.1 - 0.00019 21.0 0.0 0.00031 20.3 0.0 1.3 1 0 0 1 1 1 1 TAP C-terminal domain F-box-like PF12937.7 ELR12473.1 - 7.7e-06 25.7 0.3 1.6e-05 24.7 0.3 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ELR12473.1 - 0.0025 17.6 0.3 0.0057 16.5 0.3 1.6 1 0 0 1 1 1 1 F-box domain DUF4085 PF13315.6 ELR12474.1 - 0.0078 15.9 0.5 0.052 13.2 0.1 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF4085) SURF1 PF02104.15 ELR12476.1 - 5.8e-21 75.5 0.1 9.4e-21 74.8 0.1 1.3 1 0 0 1 1 1 1 SURF1 family Apyrase PF06079.11 ELR12478.1 - 1.1e-113 379.4 1.2 1.3e-113 379.0 1.2 1.0 1 0 0 1 1 1 1 Apyrase CsbD PF05532.12 ELR12479.1 - 9.4e-20 70.3 24.9 3.1e-11 43.0 8.2 2.0 1 1 1 2 2 2 2 CsbD-like PLAC8 PF04749.17 ELR12480.1 - 0.0073 17.3 21.5 0.014 16.3 21.5 1.6 1 1 0 1 1 1 1 PLAC8 family DUF2798 PF11391.8 ELR12480.1 - 0.098 12.7 0.3 0.58 10.2 0.2 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF2798) Apyrase PF06079.11 ELR12481.1 - 4.8e-23 81.8 0.1 9e-23 80.9 0.1 1.3 1 0 0 1 1 1 1 Apyrase WRNPLPNID PF15017.6 ELR12481.1 - 2.1 9.3 13.9 0.19 12.7 8.5 2.1 2 0 0 2 2 2 0 Putative WW-binding domain and destruction box SNARE_assoc PF09335.11 ELR12482.1 - 3.7e-15 56.5 7.0 3.7e-15 56.5 7.0 2.9 1 1 2 3 3 3 1 SNARE associated Golgi protein Afaf PF15339.6 ELR12482.1 - 0.046 13.4 0.4 0.069 12.9 0.4 1.2 1 0 0 1 1 1 0 Acrosome formation-associated factor FAM176 PF14851.6 ELR12482.1 - 0.12 12.0 0.0 0.19 11.4 0.0 1.3 1 0 0 1 1 1 0 FAM176 family UL45 PF05473.12 ELR12482.1 - 0.16 11.6 3.9 0.28 10.8 3.9 1.4 1 0 0 1 1 1 0 UL45 protein, carbohydrate-binding C-type lectin-like DUF2417 PF10329.9 ELR12482.1 - 0.17 11.3 3.3 0.26 10.7 0.1 2.2 2 0 0 2 2 2 0 Region of unknown function (DUF2417) Conotoxin PF02950.17 ELR12482.1 - 0.2 12.7 0.1 0.42 11.6 0.1 1.5 1 0 0 1 1 1 0 Conotoxin UPF0182 PF03699.13 ELR12482.1 - 4.8 5.2 6.6 6 4.9 6.6 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0182) E1-E2_ATPase PF00122.20 ELR12482.1 - 8.3 5.9 10.6 5.3 6.5 2.3 2.4 2 0 0 2 2 2 0 E1-E2 ATPase CsbD PF05532.12 ELR12483.1 - 9.4e-20 70.3 24.9 3.1e-11 43.0 8.2 2.0 1 1 1 2 2 2 2 CsbD-like Hid1 PF12722.7 ELR12485.1 - 1.3e-116 390.8 0.0 1.6e-116 390.4 0.0 1.1 1 0 0 1 1 1 1 High-temperature-induced dauer-formation protein Dymeclin PF09742.9 ELR12485.1 - 6.9e-95 318.8 0.0 8.2e-95 318.5 0.0 1.1 1 0 0 1 1 1 1 Dyggve-Melchior-Clausen syndrome protein EutQ PF06249.12 ELR12485.1 - 0.0047 16.7 0.0 0.0084 15.9 0.0 1.3 1 0 0 1 1 1 1 Ethanolamine utilisation protein EutQ AAA_lid_11 PF18198.1 ELR12485.1 - 0.042 13.7 0.0 0.11 12.3 0.0 1.7 2 0 0 2 2 2 0 Dynein heavy chain AAA lid domain Metallophos_2 PF12850.7 ELR12486.1 - 3.9e-06 27.1 0.0 0.00011 22.5 0.0 2.3 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase superfamily domain Metallophos PF00149.28 ELR12486.1 - 2.1e-05 25.2 0.4 0.0052 17.3 0.2 2.4 2 0 0 2 2 2 2 Calcineurin-like phosphoesterase UL21a PF17636.2 ELR12486.1 - 0.011 15.7 0.4 2.7 8.0 0.1 2.7 2 1 0 2 2 2 0 Viral Unique Long protein 21a GMAP PF06540.11 ELR12486.1 - 0.15 12.2 0.1 29 4.8 0.0 2.5 2 0 0 2 2 2 0 Galanin message associated peptide (GMAP) DEAD PF00270.29 ELR12487.1 - 0.00092 19.0 0.0 0.0011 18.8 0.0 1.1 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_19 PF13245.6 ELR12487.1 - 0.082 13.2 0.2 0.1 13.0 0.2 1.1 1 0 0 1 1 1 0 AAA domain UvrD-helicase PF00580.21 ELR12487.1 - 0.17 11.4 0.0 0.19 11.2 0.0 1.1 1 0 0 1 1 1 0 UvrD/REP helicase N-terminal domain RUN PF02759.19 ELR12488.1 - 3.8e-20 72.2 0.0 5.4e-20 71.7 0.0 1.2 1 0 0 1 1 1 1 RUN domain Pkinase PF00069.25 ELR12489.1 - 4.6e-59 199.9 0.1 2e-56 191.3 0.0 2.4 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR12489.1 - 9.6e-30 103.7 0.0 1.3e-25 90.2 0.0 2.3 1 1 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 ELR12489.1 - 0.00019 20.9 0.1 0.0086 15.4 0.1 2.8 2 1 0 2 2 2 1 Kinase-like GTP1_OBG PF01018.22 ELR12489.1 - 0.0015 18.1 0.6 0.0026 17.3 0.6 1.3 1 0 0 1 1 1 1 GTP1/OBG APH PF01636.23 ELR12489.1 - 0.0088 16.0 0.1 0.03 14.2 0.1 1.7 1 1 1 2 2 2 1 Phosphotransferase enzyme family MSP1a PF11670.8 ELR12490.1 - 8.7 5.6 7.4 34 3.6 7.4 2.0 1 0 0 1 1 1 0 Major surface protein 1a (MSP1a) TPR_12 PF13424.6 ELR12491.1 - 1.7e-28 98.7 10.3 8.8e-10 38.7 0.7 6.2 4 2 2 6 6 6 4 Tetratricopeptide repeat TPR_10 PF13374.6 ELR12491.1 - 1.6e-19 69.1 10.7 0.00027 20.7 0.2 7.6 8 0 0 8 8 8 3 Tetratricopeptide repeat TPR_7 PF13176.6 ELR12491.1 - 9e-09 34.8 0.1 0.05 13.7 0.0 5.0 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_2 PF07719.17 ELR12491.1 - 4.3e-08 32.7 3.4 0.035 14.2 0.6 5.5 6 0 0 6 6 5 2 Tetratricopeptide repeat TPR_1 PF00515.28 ELR12491.1 - 4e-06 26.4 0.3 0.48 10.3 0.0 5.1 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_16 PF13432.6 ELR12491.1 - 1.6e-05 25.4 4.3 0.0052 17.4 0.1 4.5 5 0 0 5 5 4 1 Tetratricopeptide repeat TPR_MalT PF17874.1 ELR12491.1 - 6.9e-05 22.4 0.2 0.45 9.8 0.0 2.6 2 1 0 3 3 3 2 MalT-like TPR region TPR_14 PF13428.6 ELR12491.1 - 0.00014 22.4 13.3 1.3 10.0 0.0 5.6 7 1 1 8 8 4 2 Tetratricopeptide repeat TPR_8 PF13181.6 ELR12491.1 - 0.00016 21.6 0.2 2.9 8.4 0.1 4.2 5 0 0 5 5 5 2 Tetratricopeptide repeat Glyco_hydro_46 PF01374.18 ELR12491.1 - 0.016 14.8 0.1 0.038 13.6 0.1 1.6 1 0 0 1 1 1 0 Glycosyl hydrolase family 46 TPR_19 PF14559.6 ELR12491.1 - 0.039 14.5 0.1 0.039 14.5 0.1 3.2 5 0 0 5 5 3 0 Tetratricopeptide repeat TPR_4 PF07721.14 ELR12491.1 - 0.18 12.5 18.1 11 7.0 0.9 5.5 5 1 0 5 5 5 0 Tetratricopeptide repeat Sec8_exocyst PF04048.14 ELR12491.1 - 0.22 11.4 1.6 0.55 10.1 0.3 2.2 3 0 0 3 3 3 0 Sec8 exocyst complex component specific domain RhoGEF PF00621.20 ELR12492.1 - 6.7e-35 121.0 0.1 8.9e-35 120.6 0.1 1.1 1 0 0 1 1 1 1 RhoGEF domain DUF4248 PF14053.6 ELR12492.1 - 0.02 14.9 0.5 0.05 13.6 0.5 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4248) PH_13 PF16652.5 ELR12492.1 - 0.098 12.5 0.0 0.21 11.4 0.0 1.4 1 0 0 1 1 1 0 Pleckstrin homology domain Ribosomal_60s PF00428.19 ELR12493.1 - 0.053 14.1 8.4 0.084 13.5 8.4 1.3 1 0 0 1 1 1 0 60s Acidic ribosomal protein DUF3669 PF12417.8 ELR12494.1 - 0.065 13.4 0.1 0.082 13.1 0.1 1.1 1 0 0 1 1 1 0 Zinc finger protein ACC_epsilon PF13822.6 ELR12494.1 - 0.1 13.3 0.0 0.12 13.0 0.0 1.2 1 0 0 1 1 1 0 Acyl-CoA carboxylase epsilon subunit RhoGEF PF00621.20 ELR12497.1 - 4.6e-05 23.7 0.7 5e-05 23.6 0.2 1.3 2 0 0 2 2 2 1 RhoGEF domain DUF4404 PF14357.6 ELR12497.1 - 0.0025 18.4 0.2 0.0026 18.3 0.2 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4404) Topoisom_bac PF01131.20 ELR12497.1 - 0.036 13.1 0.1 0.038 13.0 0.1 1.0 1 0 0 1 1 1 0 DNA topoisomerase UPF0193 PF05250.11 ELR12497.1 - 0.046 13.5 0.0 0.048 13.5 0.0 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0193) FlgM PF04316.13 ELR12497.1 - 0.048 14.0 2.3 0.061 13.7 2.3 1.2 1 0 0 1 1 1 0 Anti-sigma-28 factor, FlgM DUF4073 PF13285.6 ELR12499.1 - 0.044 13.4 0.5 0.049 13.3 0.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4073) Cnd3 PF12719.7 ELR12500.1 - 1.7e-22 79.9 0.3 3.1e-22 79.1 0.3 1.3 1 0 0 1 1 1 1 Nuclear condensing complex subunits, C-term domain HEAT PF02985.22 ELR12500.1 - 0.0077 16.4 0.6 2 8.9 0.0 3.7 3 0 0 3 3 3 1 HEAT repeat NopRA1 PF16201.5 ELR12500.1 - 0.011 15.4 0.7 1.3 8.5 0.1 2.6 2 0 0 2 2 2 0 Nucleolar pre-ribosomal-associated protein 1 HEAT_2 PF13646.6 ELR12500.1 - 0.18 12.2 2.2 2.5 8.5 0.0 3.4 4 0 0 4 4 4 0 HEAT repeats RhoGEF PF00621.20 ELR12501.1 - 3.2e-41 141.6 2.9 6.1e-41 140.7 2.9 1.5 1 0 0 1 1 1 1 RhoGEF domain ComR_TPR PF18710.1 ELR12501.1 - 0.015 14.9 1.5 0.036 13.6 0.1 2.0 1 1 1 2 2 2 0 ComR tetratricopeptide Tfb2 PF03849.14 ELR12502.1 - 4.4e-72 243.0 0.1 5.6e-72 242.7 0.1 1.1 1 0 0 1 1 1 1 Transcription factor Tfb2 Tfb2_C PF18307.1 ELR12502.1 - 8e-22 77.4 0.1 1.8e-21 76.3 0.1 1.6 1 0 0 1 1 1 1 Transcription factor Tfb2 (p52) C-terminal domain ANT PF03374.14 ELR12502.1 - 0.033 14.5 0.1 0.28 11.5 0.0 2.3 2 1 0 2 2 2 0 Phage antirepressor protein KilAC domain SinI PF08671.10 ELR12502.1 - 0.034 13.9 0.0 0.1 12.4 0.0 1.9 1 0 0 1 1 1 0 Anti-repressor SinI LNP1 PF15419.6 ELR12503.1 - 0.0036 17.5 4.9 0.0051 17.1 4.9 1.2 1 0 0 1 1 1 1 Leukemia NUP98 fusion partner 1 LicD PF04991.13 ELR12504.1 - 4.4e-09 36.8 0.1 1.9e-08 34.7 0.1 1.8 2 0 0 2 2 2 1 LicD family TPK_catalytic PF04263.16 ELR12505.1 - 2.5e-32 111.5 0.0 4.2e-32 110.7 0.0 1.3 1 0 0 1 1 1 1 Thiamin pyrophosphokinase, catalytic domain TPK_B1_binding PF04265.14 ELR12505.1 - 2.9e-17 62.2 0.0 4.8e-17 61.4 0.0 1.4 1 0 0 1 1 1 1 Thiamin pyrophosphokinase, vitamin B1 binding domain LRR_9 PF14580.6 ELR12506.1 - 2.7e-24 85.6 8.4 5.2e-11 42.4 0.0 3.5 2 1 1 3 3 3 3 Leucine-rich repeat LRR_4 PF12799.7 ELR12506.1 - 1.3e-23 82.7 28.6 2.8e-06 27.6 0.8 6.9 3 2 5 8 8 8 7 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 ELR12506.1 - 3.2e-21 74.9 22.8 9.8e-08 31.7 0.6 5.5 3 1 3 6 6 6 5 Leucine rich repeat DUF1641 PF07849.11 ELR12506.1 - 0.1 12.5 0.0 0.27 11.2 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1641) LRR_6 PF13516.6 ELR12506.1 - 0.81 9.9 22.9 16 5.9 0.1 8.2 10 0 0 10 10 10 0 Leucine Rich repeat LRR_1 PF00560.33 ELR12506.1 - 2.1 9.2 16.1 45 5.2 1.1 6.8 7 1 0 7 7 7 0 Leucine Rich Repeat FAD_binding_3 PF01494.19 ELR12507.1 - 4.7e-13 49.1 1.7 6.9e-11 42.0 1.7 2.9 1 1 0 1 1 1 1 FAD binding domain DAO PF01266.24 ELR12507.1 - 1.7e-09 37.7 0.0 0.00017 21.3 0.0 2.6 3 0 0 3 3 3 2 FAD dependent oxidoreductase Trp_halogenase PF04820.14 ELR12507.1 - 4e-06 26.0 0.0 0.0081 15.1 0.0 2.1 2 0 0 2 2 2 2 Tryptophan halogenase Thi4 PF01946.17 ELR12507.1 - 4.2e-06 26.2 0.0 8.6e-06 25.2 0.0 1.5 1 0 0 1 1 1 1 Thi4 family NAD_binding_8 PF13450.6 ELR12507.1 - 2e-05 24.7 0.0 5.2e-05 23.4 0.0 1.7 2 0 0 2 2 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 ELR12507.1 - 2e-05 24.0 0.3 6.9e-05 22.2 0.3 1.8 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 ELR12507.1 - 5.5e-05 22.4 0.2 0.24 10.4 0.3 2.8 2 1 0 2 2 2 2 Lycopene cyclase protein HI0933_like PF03486.14 ELR12507.1 - 0.00043 19.1 0.0 0.027 13.2 0.0 2.1 2 0 0 2 2 2 1 HI0933-like protein Pyr_redox_3 PF13738.6 ELR12507.1 - 0.0008 18.8 0.1 0.0033 16.7 0.0 1.9 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 ELR12507.1 - 0.0076 16.8 0.0 0.021 15.4 0.0 1.8 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 ELR12507.1 - 0.01 15.0 0.0 0.025 13.7 0.0 1.6 2 0 0 2 2 2 0 FAD binding domain GIDA PF01134.22 ELR12507.1 - 0.023 13.8 0.1 0.052 12.6 0.0 1.6 2 0 0 2 2 2 0 Glucose inhibited division protein A SE PF08491.10 ELR12507.1 - 0.12 11.4 0.0 0.19 10.7 0.0 1.3 1 0 0 1 1 1 0 Squalene epoxidase Clat_adaptor_s PF01217.20 ELR12508.1 - 5.6e-21 75.0 0.0 7.5e-21 74.6 0.0 1.2 1 0 0 1 1 1 1 Clathrin adaptor complex small chain AP-5_subunit_s1 PF15001.6 ELR12508.1 - 0.0012 18.8 0.0 0.0018 18.3 0.0 1.2 1 0 0 1 1 1 1 AP-5 complex subunit sigma-1 NIF PF03031.18 ELR12508.1 - 0.0062 16.3 0.0 0.0099 15.7 0.0 1.3 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase Pyr_redox_2 PF07992.14 ELR12509.1 - 8.1e-47 159.9 0.0 3.1e-46 157.9 0.0 1.8 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 ELR12509.1 - 3.2e-11 43.6 0.3 2.5e-07 31.1 0.0 3.0 3 1 0 3 3 2 2 Pyridine nucleotide-disulphide oxidoreductase EF-hand_1 PF00036.32 ELR12509.1 - 2.4e-10 39.2 3.3 0.00037 19.8 0.2 2.7 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 ELR12509.1 - 3.3e-08 32.8 6.1 0.0013 18.5 0.2 3.0 3 0 0 3 3 3 2 EF-hand domain EF-hand_5 PF13202.6 ELR12509.1 - 6e-08 31.8 4.9 6.9e-06 25.3 0.5 2.7 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 ELR12509.1 - 1.9e-07 30.8 1.3 0.0026 17.6 0.2 2.7 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_7 PF13499.6 ELR12509.1 - 2.4e-07 31.1 2.3 5.3e-06 26.8 2.5 2.7 1 1 1 2 2 2 2 EF-hand domain pair Pyr_redox_3 PF13738.6 ELR12509.1 - 0.0022 17.3 0.0 2.8 7.1 0.0 3.0 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 ELR12509.1 - 0.014 14.5 0.0 7.5 5.6 0.0 3.8 3 1 0 4 4 4 0 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_7 PF13241.6 ELR12509.1 - 0.093 13.2 0.2 0.69 10.4 0.0 2.4 2 0 0 2 2 2 0 Putative NAD(P)-binding SPARC_Ca_bdg PF10591.9 ELR12509.1 - 0.15 12.3 0.8 0.71 10.2 0.6 2.0 1 1 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region NAD_binding_9 PF13454.6 ELR12509.1 - 0.29 11.1 1.6 8.3 6.4 0.0 3.5 4 1 0 4 4 4 0 FAD-NAD(P)-binding DAO PF01266.24 ELR12509.1 - 1.4 8.4 3.5 57 3.1 0.0 3.4 2 1 0 3 3 3 0 FAD dependent oxidoreductase Ribosomal_S27e PF01667.17 ELR12510.1 - 4.4e-29 100.0 6.9 5.5e-29 99.6 6.9 1.1 1 0 0 1 1 1 1 Ribosomal protein S27 DUF1624 PF07786.12 ELR12512.1 - 0.0032 17.0 1.3 0.0032 17.0 1.3 2.6 3 0 0 3 3 3 1 Protein of unknown function (DUF1624) DUF4397 PF14344.6 ELR12512.1 - 0.0043 17.8 0.6 0.0094 16.7 0.6 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4397) DUF5009 PF16401.5 ELR12512.1 - 0.0071 15.9 6.6 0.058 12.9 0.6 3.2 3 0 0 3 3 3 2 Domain of unknown function (DUF5009) DUF202 PF02656.15 ELR12512.1 - 1.1 9.7 9.4 1.3e+02 3.1 0.0 4.9 4 0 0 4 4 4 0 Domain of unknown function (DUF202) Acyl_transf_3 PF01757.22 ELR12512.1 - 2.7 7.0 31.4 9.1 5.2 31.4 2.1 1 1 0 1 1 1 0 Acyltransferase family zf-C3HC4_2 PF13923.6 ELR12513.1 - 3.9e-08 33.0 4.1 9.6e-08 31.8 4.1 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 ELR12513.1 - 1.1e-06 28.5 3.2 2.2e-06 27.6 3.2 1.5 1 0 0 1 1 1 1 RING-type zinc-finger zf-rbx1 PF12678.7 ELR12513.1 - 1.6e-06 28.3 3.2 4.2e-06 26.9 3.2 1.8 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-Nse PF11789.8 ELR12513.1 - 5.5e-06 26.1 0.1 1.1e-05 25.1 0.1 1.5 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_2 PF13639.6 ELR12513.1 - 2.4e-05 24.6 3.7 7.2e-05 23.0 3.7 1.8 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 ELR12513.1 - 9.1e-05 22.2 2.2 0.0002 21.1 2.2 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_6 PF14835.6 ELR12513.1 - 0.00054 19.8 0.3 0.0011 18.8 0.3 1.5 1 0 0 1 1 1 1 zf-RING of BARD1-type protein zf-C3HC4_4 PF15227.6 ELR12513.1 - 0.00081 19.5 1.7 0.0016 18.6 1.7 1.5 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING Prok-RING_4 PF14447.6 ELR12513.1 - 0.012 15.5 4.2 0.033 14.0 4.1 1.8 1 1 0 1 1 1 0 Prokaryotic RING finger family 4 zf-C3HC4_3 PF13920.6 ELR12513.1 - 0.013 15.3 2.2 0.027 14.3 2.2 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) CAP_N PF01213.19 ELR12513.1 - 0.024 14.1 1.0 0.024 14.1 1.0 1.5 2 0 0 2 2 2 0 Adenylate cyclase associated (CAP) N terminal zf-RING_5 PF14634.6 ELR12513.1 - 0.025 14.5 4.4 0.082 12.9 4.2 1.9 1 1 1 2 2 2 0 zinc-RING finger domain zf-ANAPC11 PF12861.7 ELR12513.1 - 0.031 14.3 5.2 0.054 13.6 2.4 2.5 1 1 2 3 3 3 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-MIZ PF02891.20 ELR12513.1 - 0.046 13.5 2.6 0.085 12.6 2.6 1.5 1 0 0 1 1 1 0 MIZ/SP-RING zinc finger U-box PF04564.15 ELR12513.1 - 0.047 13.9 0.0 0.11 12.7 0.0 1.5 1 0 0 1 1 1 0 U-box domain zf-RING_10 PF16685.5 ELR12513.1 - 0.081 13.1 2.9 0.15 12.3 2.9 1.4 1 0 0 1 1 1 0 zinc RING finger of MSL2 Mak16 PF04874.14 ELR12513.1 - 0.11 13.1 7.3 2 9.1 0.0 3.1 3 0 0 3 3 3 0 Mak16 protein C-terminal region Mito_fiss_reg PF05308.11 ELR12513.1 - 0.12 12.4 1.8 0.21 11.6 1.8 1.3 1 0 0 1 1 1 0 Mitochondrial fission regulator GST_C_3 PF14497.6 ELR12514.1 - 7.8e-14 51.7 0.0 1.1e-13 51.2 0.0 1.2 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 ELR12514.1 - 4.4e-09 36.6 0.0 9e-09 35.6 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 ELR12514.1 - 1e-05 25.7 0.1 1.5e-05 25.2 0.1 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Tom37 PF10568.9 ELR12514.1 - 0.0014 18.9 0.0 0.0028 18.0 0.0 1.5 2 0 0 2 2 2 1 Outer mitochondrial membrane transport complex protein zf-RRPl_C4 PF17026.5 ELR12514.1 - 0.0081 16.2 0.0 0.014 15.5 0.0 1.3 1 0 0 1 1 1 1 Putative ribonucleoprotein zinc-finger pf C4 type GST_C_2 PF13410.6 ELR12514.1 - 0.012 15.6 0.1 0.025 14.6 0.1 1.6 1 1 0 1 1 1 0 Glutathione S-transferase, C-terminal domain GST_C_6 PF17171.4 ELR12514.1 - 0.013 15.2 0.0 0.032 14.0 0.0 1.7 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.6 ELR12514.1 - 0.078 13.3 0.0 0.16 12.3 0.0 1.5 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 ELR12514.1 - 0.14 12.6 0.0 0.29 11.6 0.0 1.5 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain WD40 PF00400.32 ELR12515.1 - 2.6e-08 34.4 7.6 0.013 16.3 0.3 5.5 5 1 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ELR12515.1 - 9.5e-05 22.6 0.0 0.043 14.1 0.0 3.9 3 1 0 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain PD40 PF07676.12 ELR12515.1 - 0.13 12.2 0.1 2.3 8.3 0.0 2.9 2 0 0 2 2 2 0 WD40-like Beta Propeller Repeat BTB PF00651.31 ELR12516.1 - 3.8e-37 126.9 0.9 1.6e-17 63.7 0.0 3.2 2 1 1 3 3 3 3 BTB/POZ domain BACK PF07707.15 ELR12516.1 - 0.097 12.8 0.8 2.5 8.2 0.1 2.8 2 1 1 3 3 3 0 BTB And C-terminal Kelch Kelch_1 PF01344.25 ELR12516.1 - 0.17 11.5 0.3 0.27 10.8 0.3 1.3 1 0 0 1 1 1 0 Kelch motif Kelch_5 PF13854.6 ELR12517.1 - 8.8e-27 92.6 0.4 6.4e-08 32.4 0.1 4.2 4 0 0 4 4 4 4 Kelch motif Kelch_4 PF13418.6 ELR12517.1 - 7.7e-26 89.9 2.3 1.6e-10 40.8 0.0 4.1 4 0 0 4 4 4 4 Galactose oxidase, central domain Kelch_2 PF07646.15 ELR12517.1 - 1.3e-24 85.2 1.1 2e-08 33.9 0.0 4.2 4 0 0 4 4 4 4 Kelch motif Kelch_6 PF13964.6 ELR12517.1 - 1.8e-22 78.8 0.1 1.6e-09 37.7 0.0 4.2 4 0 0 4 4 4 4 Kelch motif Kelch_1 PF01344.25 ELR12517.1 - 9.5e-22 76.3 0.0 4e-09 35.9 0.0 4.2 4 0 0 4 4 4 4 Kelch motif Kelch_3 PF13415.6 ELR12517.1 - 3.4e-14 52.7 9.2 9.1e-07 29.0 0.1 4.9 4 1 0 4 4 4 3 Galactose oxidase, central domain AAA_28 PF13521.6 ELR12518.1 - 0.011 16.0 0.0 0.021 15.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain GTP_cyclohydroI PF01227.22 ELR12519.1 - 1e-75 253.1 0.5 1.3e-75 252.8 0.5 1.1 1 0 0 1 1 1 1 GTP cyclohydrolase I QueF PF14489.6 ELR12519.1 - 4.5e-05 23.5 0.0 9.1e-05 22.5 0.0 1.5 1 0 0 1 1 1 1 QueF-like protein AT_hook PF02178.19 ELR12520.1 - 0.0076 16.0 3.6 0.021 14.6 3.6 1.8 1 0 0 1 1 1 1 AT hook motif LRR_4 PF12799.7 ELR12521.1 - 0.0032 17.8 0.1 28 5.3 0.0 3.8 3 0 0 3 3 3 1 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 ELR12521.1 - 0.0033 17.4 0.4 8.8 6.7 0.0 4.7 5 0 0 5 5 5 1 Leucine Rich repeat LRR_8 PF13855.6 ELR12521.1 - 0.013 15.3 1.8 6.8 6.5 0.1 3.5 2 1 1 3 3 3 0 Leucine rich repeat DUF4389 PF14333.6 ELR12521.1 - 0.17 11.8 0.0 0.44 10.5 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4389) Zn_clus PF00172.18 ELR12522.1 - 6.4e-05 23.0 7.8 0.00012 22.2 7.8 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain PAS_9 PF13426.7 ELR12522.1 - 0.0011 19.2 0.0 0.0021 18.3 0.0 1.4 1 0 0 1 1 1 1 PAS domain PAS_3 PF08447.12 ELR12522.1 - 0.0018 18.5 0.0 0.0031 17.8 0.0 1.3 1 0 0 1 1 1 1 PAS fold PAS PF00989.25 ELR12522.1 - 0.014 15.4 0.0 0.028 14.4 0.0 1.4 1 0 0 1 1 1 0 PAS fold PAS_8 PF13188.7 ELR12522.1 - 0.014 15.4 0.0 0.029 14.4 0.0 1.5 1 0 0 1 1 1 0 PAS domain SKA2 PF16740.5 ELR12522.1 - 0.063 13.1 0.6 0.13 12.1 0.6 1.4 1 0 0 1 1 1 0 Spindle and kinetochore-associated protein 2 bZIP_1 PF00170.21 ELR12522.1 - 0.14 12.3 0.8 0.65 10.1 0.8 1.9 2 0 0 2 2 2 0 bZIP transcription factor DivIC PF04977.15 ELR12522.1 - 0.17 11.7 0.7 0.32 10.8 0.7 1.4 1 0 0 1 1 1 0 Septum formation initiator FlaC_arch PF05377.11 ELR12522.1 - 0.36 11.2 0.8 0.66 10.4 0.8 1.3 1 0 0 1 1 1 0 Flagella accessory protein C (FlaC) Chlam_PMP PF02415.17 ELR12522.1 - 2.7 8.6 6.5 31 5.3 0.7 3.3 2 0 0 2 2 2 0 Chlamydia polymorphic membrane protein (Chlamydia_PMP) repeat Arm PF00514.23 ELR12523.1 - 5.5e-26 89.7 6.2 8.3e-05 22.5 0.0 8.3 8 0 0 8 8 8 6 Armadillo/beta-catenin-like repeat Atx10homo_assoc PF09759.9 ELR12523.1 - 2.5e-13 49.9 4.5 0.045 13.8 0.0 6.7 3 2 5 8 8 8 4 Spinocerebellar ataxia type 10 protein domain Arm_2 PF04826.13 ELR12523.1 - 2.1e-06 27.4 4.4 0.1 12.1 0.0 4.2 4 1 1 5 5 5 3 Armadillo-like HEAT_EZ PF13513.6 ELR12523.1 - 1.3e-05 25.6 1.0 0.54 10.8 0.1 6.0 7 0 0 7 7 7 1 HEAT-like repeat HEAT PF02985.22 ELR12523.1 - 0.0029 17.7 0.3 21 5.7 0.0 5.3 5 0 0 5 5 5 0 HEAT repeat DUF3361 PF11841.8 ELR12523.1 - 0.0067 16.4 0.9 0.06 13.3 0.1 2.8 2 1 1 3 3 3 1 Domain of unknown function (DUF3361) Cu2_monoox_C PF03712.15 ELR12523.1 - 0.016 14.7 0.4 0.62 9.6 0.2 2.3 2 0 0 2 2 2 0 Copper type II ascorbate-dependent monooxygenase, C-terminal domain UNC45-central PF11701.8 ELR12523.1 - 0.016 15.1 5.9 0.09 12.7 1.5 3.2 2 1 0 2 2 2 0 Myosin-binding striated muscle assembly central WAPL PF07814.13 ELR12523.1 - 0.023 13.5 1.4 0.23 10.2 0.1 2.5 2 1 1 3 3 3 0 Wings apart-like protein regulation of heterochromatin Ric8 PF10165.9 ELR12523.1 - 0.062 12.3 0.4 0.47 9.4 0.0 2.3 2 1 1 3 3 3 0 Guanine nucleotide exchange factor synembryn dsDNA_bind PF01984.20 ELR12523.1 - 0.21 11.9 1.2 0.46 10.8 0.0 2.2 2 0 0 2 2 2 0 Double-stranded DNA-binding domain DASH_Spc19 PF08287.11 ELR12523.1 - 0.34 10.8 1.3 5.6 6.8 0.0 2.4 2 0 0 2 2 2 0 Spc19 ERM PF00769.19 ELR12524.1 - 0.14 11.9 0.0 0.19 11.5 0.0 1.1 1 0 0 1 1 1 0 Ezrin/radixin/moesin family M20_dimer PF07687.14 ELR12525.1 - 3.2e-06 27.0 0.0 4.9e-06 26.4 0.0 1.3 1 0 0 1 1 1 1 Peptidase dimerisation domain BNR PF02012.20 ELR12525.1 - 0.078 13.0 0.1 0.18 11.9 0.1 1.6 1 0 0 1 1 1 0 BNR/Asp-box repeat Peptidase_M20 PF01546.28 ELR12526.1 - 5.8e-20 71.9 0.0 8.5e-20 71.3 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 ELR12526.1 - 0.00013 21.8 0.0 0.063 13.2 0.0 2.3 2 0 0 2 2 2 2 Peptidase dimerisation domain Peptidase_M28 PF04389.17 ELR12526.1 - 0.0015 18.2 0.0 0.0093 15.7 0.0 2.1 1 1 0 1 1 1 1 Peptidase family M28 DUF1830 PF08865.11 ELR12526.1 - 0.034 14.1 0.0 0.067 13.2 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1830) YejG PF13989.6 ELR12526.1 - 0.1 13.0 0.0 0.26 11.7 0.0 1.7 1 0 0 1 1 1 0 YejG-like protein G_glu_transpept PF01019.21 ELR12527.1 - 4.8e-61 207.1 0.7 3.8e-49 167.8 0.0 2.1 2 0 0 2 2 2 2 Gamma-glutamyltranspeptidase CysG_dimeriser PF10414.9 ELR12527.1 - 0.12 12.1 0.1 0.32 10.8 0.1 1.7 1 0 0 1 1 1 0 Sirohaem synthase dimerisation region MT-A70 PF05063.14 ELR12528.1 - 7.7e-09 35.7 0.1 1.3e-08 34.9 0.1 1.5 1 0 0 1 1 1 1 MT-A70 DUF1768 PF08719.11 ELR12529.1 - 9.8e-30 103.9 0.0 1.7e-29 103.2 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1768) XPA_C PF05181.12 ELR12529.1 - 7.3e-07 29.1 0.0 1.3e-06 28.3 0.0 1.4 1 0 0 1 1 1 1 XPA protein C-terminus Vfa1 PF08432.10 ELR12530.1 - 0.52 10.6 9.4 0.37 11.1 2.6 2.2 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 DUF1993 PF09351.10 ELR12530.1 - 0.65 10.1 4.3 0.56 10.3 0.2 2.4 1 1 2 3 3 3 0 Domain of unknown function (DUF1993) E6 PF00518.17 ELR12530.1 - 1.7 9.1 9.9 0.098 13.1 2.1 2.5 2 1 1 3 3 3 0 Early Protein (E6) DUF4446 PF14584.6 ELR12530.1 - 2.6 8.0 7.9 1.1 9.2 1.4 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF4446) Ank_3 PF13606.6 ELR12531.1 - 1e-05 25.5 0.1 2.6e-05 24.3 0.1 1.7 2 0 0 2 2 2 1 Ankyrin repeat Ank_4 PF13637.6 ELR12531.1 - 0.00018 22.0 0.1 0.058 14.0 0.0 1.9 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 ELR12531.1 - 0.00097 19.5 0.1 0.0025 18.2 0.0 1.7 2 0 0 2 2 2 1 Ankyrin repeat Ank_2 PF12796.7 ELR12531.1 - 0.0011 19.5 0.0 0.0014 19.2 0.0 1.3 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 ELR12531.1 - 0.028 14.8 0.0 0.064 13.6 0.0 1.7 2 0 0 2 2 2 0 Ankyrin repeats (many copies) Ank_2 PF12796.7 ELR12532.1 - 3.5e-14 53.1 2.3 2.5e-07 31.2 0.4 2.1 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ELR12532.1 - 1.9e-12 47.4 0.1 3.9e-07 30.5 0.0 2.8 1 1 2 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.30 ELR12532.1 - 1.2e-09 38.2 6.7 0.0017 18.7 0.2 4.4 3 2 2 5 5 5 3 Ankyrin repeat Ank_3 PF13606.6 ELR12532.1 - 9e-09 34.9 0.1 0.0067 16.9 0.0 3.6 4 0 0 4 4 4 2 Ankyrin repeat Ank_5 PF13857.6 ELR12532.1 - 0.0081 16.5 0.4 0.13 12.6 0.1 2.7 2 1 1 3 3 3 1 Ankyrin repeats (many copies) CAML PF14963.6 ELR12534.1 - 0.095 12.8 0.3 0.13 12.4 0.3 1.2 1 0 0 1 1 1 0 Calcium signal-modulating cyclophilin ligand Methyltransf_16 PF10294.9 ELR12535.1 - 7.8e-32 110.4 0.0 1e-31 110.0 0.0 1.1 1 0 0 1 1 1 1 Lysine methyltransferase MTS PF05175.14 ELR12535.1 - 1.6e-05 24.5 0.0 2.4e-05 23.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Rsm22 PF09243.10 ELR12535.1 - 0.0062 15.9 0.0 0.0088 15.4 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial small ribosomal subunit Rsm22 GidB PF02527.15 ELR12535.1 - 0.0062 15.9 0.0 0.0092 15.3 0.0 1.2 1 0 0 1 1 1 1 rRNA small subunit methyltransferase G DUF938 PF06080.12 ELR12535.1 - 0.044 13.5 0.0 0.062 13.1 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF938) Methyltransf_12 PF08242.12 ELR12535.1 - 0.059 14.1 0.0 0.12 13.2 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Band_7 PF01145.25 ELR12536.1 - 1.1e-30 107.0 2.8 1.3e-30 106.7 0.2 2.1 2 0 0 2 2 2 1 SPFH domain / Band 7 family Band_7_C PF16200.5 ELR12536.1 - 2.9e-25 88.1 0.8 5.5e-25 87.2 0.8 1.5 1 0 0 1 1 1 1 C-terminal region of band_7 RasGEF PF00617.19 ELR12537.1 - 5.3e-68 228.7 12.7 5.1e-36 124.5 2.7 4.6 5 1 1 6 6 6 3 RasGEF domain RhoGAP PF00620.27 ELR12537.1 - 3.8e-29 101.5 1.2 1.1e-28 100.0 0.4 2.3 2 0 0 2 2 2 1 RhoGAP domain RasGEF_N PF00618.20 ELR12537.1 - 1e-18 67.5 2.8 3.4e-12 46.5 0.7 2.7 2 0 0 2 2 2 2 RasGEF N-terminal motif SH2 PF00017.24 ELR12537.1 - 2.3e-09 37.2 0.1 6.6e-08 32.5 0.0 3.1 3 0 0 3 3 3 1 SH2 domain Cbl_N2 PF02761.14 ELR12537.1 - 9.2e-06 26.3 0.0 0.0003 21.5 0.0 3.3 3 0 0 3 3 3 1 CBL proto-oncogene N-terminus, EF hand-like domain DUF3759 PF12585.8 ELR12537.1 - 0.11 12.5 0.0 29 4.8 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3759) DSPc PF00782.20 ELR12538.1 - 1.6e-07 31.2 0.0 2.3e-07 30.7 0.0 1.2 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 ELR12538.1 - 1.4e-05 24.8 0.0 1.8e-05 24.4 0.0 1.1 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.6 ELR12538.1 - 0.001 19.1 0.0 0.0013 18.8 0.0 1.2 1 0 0 1 1 1 1 Tyrosine phosphatase family PTPlike_phytase PF14566.6 ELR12538.1 - 0.03 14.4 0.0 0.041 14.0 0.0 1.2 1 0 0 1 1 1 0 Inositol hexakisphosphate Dioxygenase_C PF00775.21 ELR12539.1 - 6.9e-09 35.4 0.3 3.3e-08 33.2 0.3 2.1 1 1 0 1 1 1 1 Dioxygenase CENP-B_dimeris PF09026.10 ELR12539.1 - 0.0077 16.6 8.6 0.014 15.7 8.6 1.4 1 0 0 1 1 1 1 Centromere protein B dimerisation domain GCIP PF13324.6 ELR12539.1 - 0.28 10.8 0.6 0.39 10.3 0.6 1.1 1 0 0 1 1 1 0 Grap2 and cyclin-D-interacting PBP1_TM PF14812.6 ELR12539.1 - 0.73 10.2 9.9 1.3 9.4 9.9 1.3 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal RXT2_N PF08595.11 ELR12539.1 - 2.1 8.4 4.6 3.6 7.6 4.6 1.3 1 0 0 1 1 1 0 RXT2-like, N-terminal Cwf_Cwc_15 PF04889.12 ELR12539.1 - 6.5 6.4 14.0 9.5 5.9 14.0 1.1 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein NOA36 PF06524.12 ELR12539.1 - 8.1 5.7 12.9 12 5.1 12.9 1.1 1 0 0 1 1 1 0 NOA36 protein Evf PF18270.1 ELR12540.1 - 0.08 12.4 0.0 0.11 11.9 0.0 1.2 1 0 0 1 1 1 0 Virulence factor Evf Evf PF18270.1 ELR12543.1 - 0.11 11.9 0.0 0.16 11.4 0.0 1.2 1 0 0 1 1 1 0 Virulence factor Evf DUF4407 PF14362.6 ELR12543.1 - 0.24 10.7 26.1 0.33 10.3 26.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Borrelia_P83 PF05262.11 ELR12543.1 - 0.52 8.7 35.1 0.63 8.5 35.1 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein SpoIIIAH PF12685.7 ELR12543.1 - 5.4 6.8 20.5 7.9 6.2 20.5 1.3 1 0 0 1 1 1 0 SpoIIIAH-like protein Asp-B-Hydro_N PF05279.11 ELR12543.1 - 7 6.6 44.0 9.8 6.2 44.0 1.1 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region BBE PF08031.12 ELR12544.1 - 3.9e-06 26.9 0.8 6.3e-06 26.2 0.1 1.8 2 1 0 2 2 2 1 Berberine and berberine like Pkinase_Tyr PF07714.17 ELR12545.1 - 3.1e-123 410.1 0.0 1.1e-60 205.1 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 ELR12545.1 - 3.7e-109 364.2 0.0 2.8e-55 187.5 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain PBP_like_2 PF12849.7 ELR12545.1 - 5e-23 82.2 16.8 6.1e-12 45.8 6.3 2.3 2 0 0 2 2 2 2 PBP superfamily domain Guanylate_cyc PF00211.20 ELR12545.1 - 1.1e-14 54.5 0.0 2.1e-14 53.6 0.0 1.4 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain APH PF01636.23 ELR12545.1 - 9.9e-08 32.2 0.1 0.00016 21.7 0.0 3.1 3 0 0 3 3 3 2 Phosphotransferase enzyme family Haspin_kinase PF12330.8 ELR12545.1 - 0.00011 21.3 0.1 0.0076 15.2 0.1 2.6 3 0 0 3 3 3 1 Haspin like kinase domain Kdo PF06293.14 ELR12545.1 - 0.00012 21.5 0.3 0.029 13.7 0.1 2.3 2 0 0 2 2 2 2 Lipopolysaccharide kinase (Kdo/WaaP) family SKG6 PF08693.10 ELR12545.1 - 0.00031 20.1 3.6 0.00031 20.1 3.6 2.2 2 0 0 2 2 2 1 Transmembrane alpha-helix domain Kinase-like PF14531.6 ELR12545.1 - 0.0015 17.9 0.0 0.39 10.0 0.0 2.2 2 0 0 2 2 2 2 Kinase-like EGF_2 PF07974.13 ELR12545.1 - 0.0019 18.5 11.8 0.0038 17.6 11.8 1.4 1 0 0 1 1 1 1 EGF-like domain SprA-related PF12118.8 ELR12545.1 - 2.5 7.2 6.8 0.4 9.8 2.6 1.7 2 0 0 2 2 2 0 SprA-related family hEGF PF12661.7 ELR12545.1 - 3.5 8.4 7.5 9.2 7.1 7.5 1.7 1 0 0 1 1 1 0 Human growth factor-like EGF Cyclase PF04199.13 ELR12546.1 - 2.4e-06 27.8 0.0 0.0039 17.4 0.0 2.2 1 1 1 2 2 2 2 Putative cyclase NRIP1_repr_1 PF15687.5 ELR12548.1 - 0.0065 16.2 0.6 0.0083 15.8 0.2 1.4 1 1 0 1 1 1 1 Nuclear receptor-interacting protein 1 repression 1 Oxysterol_BP PF01237.18 ELR12551.1 - 4.8e-91 305.4 3.9 2.4e-82 276.7 0.0 2.2 1 1 1 2 2 2 2 Oxysterol-binding protein PWWP PF00855.17 ELR12551.1 - 0.34 11.4 0.1 0.34 11.4 0.1 2.5 2 0 0 2 2 2 0 PWWP domain SR-25 PF10500.9 ELR12552.1 - 0.00026 20.7 7.9 0.00026 20.7 7.9 3.1 3 0 0 3 3 3 2 Nuclear RNA-splicing-associated protein BAR PF03114.18 ELR12552.1 - 0.033 13.9 0.7 0.033 13.9 0.7 2.3 3 0 0 3 3 3 0 BAR domain Hamartin PF04388.12 ELR12552.1 - 3.4 6.2 11.0 4.5 5.8 11.0 1.3 1 0 0 1 1 1 0 Hamartin protein SIR2 PF02146.17 ELR12553.1 - 1.7e-56 190.9 0.0 2.3e-56 190.5 0.0 1.2 1 0 0 1 1 1 1 Sir2 family Pyrid_oxidase_2 PF13883.6 ELR12554.1 - 6.7e-05 22.9 0.0 0.00011 22.2 0.0 1.3 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase DUF2470 PF10615.9 ELR12554.1 - 0.00047 20.7 0.0 0.0012 19.4 0.0 1.8 1 1 0 1 1 1 1 Protein of unknown function (DUF2470) CBM27 PF09212.10 ELR12554.1 - 0.14 12.3 0.0 0.6 10.3 0.0 2.0 1 1 1 2 2 2 0 Carbohydrate binding module 27 Sin3a_C PF16879.5 ELR12555.1 - 4.5e-68 230.1 2.2 4.5e-68 230.1 2.2 3.9 4 0 0 4 4 4 2 C-terminal domain of Sin3a protein PAH PF02671.21 ELR12555.1 - 3.8e-43 145.4 13.0 1.3e-17 63.6 5.0 3.8 3 0 0 3 3 3 3 Paired amphipathic helix repeat Sin3_corepress PF08295.12 ELR12555.1 - 2.7e-25 88.3 0.0 1.2e-24 86.2 0.0 2.2 1 0 0 1 1 1 1 Sin3 family co-repressor SAPS PF04499.15 ELR12555.1 - 9 4.9 8.9 7.7 5.2 4.4 2.1 2 0 0 2 2 2 0 SIT4 phosphatase-associated protein FixS PF03597.15 ELR12556.1 - 2.4 7.9 4.2 1.9 8.3 0.3 2.4 2 0 0 2 2 2 0 Cytochrome oxidase maturation protein cbb3-type Cnd2 PF05786.14 ELR12558.1 - 6.7e-112 375.6 0.1 1.4e-111 374.5 0.1 1.5 1 1 0 1 1 1 1 Condensin complex subunit 2 CNDH2_N PF06278.11 ELR12558.1 - 2.6e-06 27.6 0.1 2.6e-06 27.6 0.1 2.5 2 0 0 2 2 2 1 Condensin II complex subunit CAP-H2 or CNDH2, N-terminal KCT2 PF17818.1 ELR12558.1 - 0.047 13.8 1.1 0.16 12.1 1.1 1.9 1 0 0 1 1 1 0 Keratinocyte-associated gene product ABC_trans_aux PF03886.13 ELR12558.1 - 0.052 13.1 0.0 0.15 11.7 0.0 1.7 1 0 0 1 1 1 0 ABC-type transport auxiliary lipoprotein component RPA43_OB PF17875.1 ELR12558.1 - 0.4 11.3 7.1 0.1 13.3 1.8 2.5 2 0 0 2 2 2 0 RPA43 OB domain in RNA Pol I UCH PF00443.29 ELR12560.1 - 4.6e-73 245.9 0.0 6.5e-73 245.4 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase DUSP PF06337.12 ELR12560.1 - 8.8e-18 64.7 0.0 2.3e-17 63.4 0.0 1.8 1 0 0 1 1 1 1 DUSP domain UCH_1 PF13423.6 ELR12560.1 - 1.7e-10 41.0 2.1 0.00028 20.6 1.0 2.6 2 1 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase zf_C2H2_10 PF18414.1 ELR12560.1 - 2e-06 27.2 1.7 4.1e-06 26.2 1.7 1.5 1 0 0 1 1 1 1 C2H2 type zinc-finger zf_UBZ PF18439.1 ELR12560.1 - 0.033 13.8 0.6 1.3 8.7 0.1 2.8 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger zf-C2H2 PF00096.26 ELR12560.1 - 0.053 14.0 1.8 0.24 11.9 0.0 3.0 3 0 0 3 3 3 0 Zinc finger, C2H2 type zf-ACC PF17848.1 ELR12560.1 - 0.19 11.8 0.1 0.19 11.8 0.1 2.4 3 0 0 3 3 3 0 Acetyl-coA carboxylase zinc finger domain zf-C2H2_6 PF13912.6 ELR12560.1 - 0.62 10.1 3.8 0.48 10.5 0.1 2.5 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2H2_4 PF13894.6 ELR12560.1 - 0.95 10.5 0.0 0.95 10.5 0.0 3.2 3 0 0 3 3 3 0 C2H2-type zinc finger Metallophos PF00149.28 ELR12561.1 - 9.8e-18 65.4 0.1 1.6e-17 64.7 0.1 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase F-box-like PF12937.7 ELR12561.1 - 2.5e-06 27.3 0.5 6.3e-06 26.0 0.3 1.8 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 ELR12561.1 - 0.002 18.0 0.6 0.069 13.1 0.1 2.5 2 0 0 2 2 2 1 F-box domain Glyco_hydro_15 PF00723.21 ELR12562.1 - 3e-07 29.6 0.0 8.3e-07 28.1 0.0 1.6 1 1 0 1 1 1 1 Glycosyl hydrolases family 15 TPR_10 PF13374.6 ELR12562.1 - 0.017 15.0 0.1 0.049 13.5 0.0 1.9 2 0 0 2 2 2 0 Tetratricopeptide repeat Glyco_hydro_63 PF03200.16 ELR12562.1 - 0.066 12.0 0.0 0.15 10.8 0.0 1.5 2 0 0 2 2 2 0 Glycosyl hydrolase family 63 C-terminal domain CHCH PF06747.13 ELR12563.1 - 0.045 13.9 6.1 0.15 12.3 0.0 3.6 3 0 0 3 3 3 0 CHCH domain UPF0203 PF05254.12 ELR12563.1 - 0.053 13.8 0.2 0.12 12.6 0.2 1.6 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0203) UCR_hinge PF02320.16 ELR12563.1 - 0.11 12.8 1.5 0.24 11.6 0.3 2.2 2 0 0 2 2 2 0 Ubiquinol-cytochrome C reductase hinge protein CagY_M PF07337.11 ELR12563.1 - 0.82 9.3 3.3 11 5.7 0.2 2.6 2 0 0 2 2 2 0 DC-EC Repeat ETF PF01012.21 ELR12564.1 - 3.9e-40 137.7 3.7 5.4e-40 137.2 3.7 1.2 1 0 0 1 1 1 1 Electron transfer flavoprotein domain ETF_alpha PF00766.19 ELR12564.1 - 5e-37 125.8 0.2 5e-37 125.8 0.2 2.2 3 0 0 3 3 3 1 Electron transfer flavoprotein FAD-binding domain Shufflon_N PF04917.12 ELR12564.1 - 0.0037 16.8 0.2 0.0058 16.1 0.2 1.2 1 0 0 1 1 1 1 Bacterial shufflon protein, N-terminal constant region Avl9 PF09794.9 ELR12566.1 - 0.066 11.9 0.0 0.07 11.8 0.0 1.0 1 0 0 1 1 1 0 Transport protein Avl9 RAP-1 PF03085.15 ELR12566.1 - 0.2 11.3 0.0 0.22 11.2 0.0 1.0 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) ADP_ribosyl_GH PF03747.14 ELR12568.1 - 0.01 15.6 0.0 0.01 15.6 0.0 1.1 1 0 0 1 1 1 0 ADP-ribosylglycohydrolase ST7 PF04184.12 ELR12568.1 - 0.065 11.7 0.1 0.073 11.5 0.1 1.0 1 0 0 1 1 1 0 ST7 protein SWIRM-assoc_2 PF16496.5 ELR12569.1 - 0.86 8.4 4.3 1 8.1 4.3 1.1 1 0 0 1 1 1 0 SWIRM-associated domain at the N-terminal DUF4551 PF15087.6 ELR12569.1 - 1.3 7.7 5.0 1.3 7.8 5.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) SP_C-Propep PF08999.10 ELR12570.1 - 0.01 15.6 0.0 0.012 15.4 0.0 1.2 1 0 0 1 1 1 0 Surfactant protein C, N terminal propeptide SieB PF14163.6 ELR12570.1 - 0.082 12.4 0.0 0.096 12.2 0.0 1.4 1 0 0 1 1 1 0 Super-infection exclusion protein B PDR_assoc PF08370.11 ELR12570.1 - 0.087 12.6 0.1 0.13 12.1 0.1 1.3 1 0 0 1 1 1 0 Plant PDR ABC transporter associated DUF334 PF03904.13 ELR12570.1 - 0.1 12.1 0.2 0.16 11.5 0.1 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF334) CAAD PF14159.6 ELR12570.1 - 0.77 9.6 3.9 0.28 11.0 1.4 1.6 2 0 0 2 2 2 0 CAAD domains of cyanobacterial aminoacyl-tRNA synthetase Synaptobrevin PF00957.21 ELR12570.1 - 1.7 8.5 4.4 1.4 8.8 3.1 1.4 2 0 0 2 2 2 0 Synaptobrevin PH PF00169.29 ELR12571.1 - 1.1e-27 96.6 9.9 1.7e-20 73.5 0.8 2.8 3 0 0 3 3 3 2 PH domain RasGAP PF00616.19 ELR12571.1 - 1.1e-22 80.7 0.0 3.4e-18 66.1 0.0 2.4 2 0 0 2 2 2 2 GTPase-activator protein for Ras-like GTPase PH_11 PF15413.6 ELR12571.1 - 2e-12 47.5 12.8 3e-08 34.0 0.7 3.1 3 0 0 3 3 3 2 Pleckstrin homology domain PH_3 PF14593.6 ELR12571.1 - 6.6e-08 32.6 2.0 7.8e-06 25.9 0.3 2.5 2 0 0 2 2 2 2 PH domain PH_8 PF15409.6 ELR12571.1 - 2.6e-05 24.4 2.1 0.0095 16.2 0.1 2.7 2 0 0 2 2 2 2 Pleckstrin homology domain DNA_pol_B_exo1 PF03104.19 ELR12571.1 - 0.014 14.6 0.8 1 8.4 0.4 2.1 2 0 0 2 2 2 0 DNA polymerase family B, exonuclease domain PH_13 PF16652.5 ELR12571.1 - 0.038 13.8 0.9 0.14 12.0 0.1 2.3 2 0 0 2 2 2 0 Pleckstrin homology domain Fib_alpha PF08702.10 ELR12571.1 - 0.15 12.2 3.5 0.35 11.0 3.5 1.6 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family FHA PF00498.26 ELR12572.1 - 3.6e-14 52.9 0.0 5.4e-14 52.3 0.0 1.3 1 0 0 1 1 1 1 FHA domain Yop-YscD_cpl PF16697.5 ELR12572.1 - 0.00062 20.0 0.0 0.0094 16.2 0.0 2.0 1 1 1 2 2 2 1 Inner membrane component of T3SS, cytoplasmic domain FAD_binding_1 PF00667.20 ELR12573.1 - 5.1e-28 98.1 0.1 2.1e-16 60.2 0.3 2.3 1 1 1 2 2 2 2 FAD binding domain Flavodoxin_1 PF00258.25 ELR12573.1 - 7.1e-25 87.9 0.0 1.4e-24 86.9 0.0 1.4 1 0 0 1 1 1 1 Flavodoxin NAD_binding_1 PF00175.21 ELR12573.1 - 1.7e-20 73.7 0.0 3.6e-20 72.6 0.0 1.6 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain DUF1768 PF08719.11 ELR12574.1 - 7.4e-14 52.3 0.0 2.9e-13 50.4 0.0 2.0 1 1 0 1 1 1 1 Domain of unknown function (DUF1768) Glyco_hydro_18 PF00704.28 ELR12575.1 - 0.00018 21.4 0.0 0.0002 21.2 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 Glyco_hydro_85 PF03644.13 ELR12575.1 - 0.022 14.2 0.0 0.031 13.7 0.0 1.3 1 0 0 1 1 1 0 Glycosyl hydrolase family 85 Sterol-sensing PF12349.8 ELR12575.1 - 0.033 14.0 0.0 0.051 13.4 0.0 1.3 1 0 0 1 1 1 0 Sterol-sensing domain of SREBP cleavage-activation F-box PF00646.33 ELR12576.1 - 0.029 14.3 0.0 0.089 12.7 0.0 1.8 1 0 0 1 1 1 0 F-box domain Pannexin_like PF12534.8 ELR12576.1 - 0.2 10.7 0.0 0.31 10.1 0.0 1.2 1 0 0 1 1 1 0 Pannexin-like TM region of LRRC8 FF PF01846.19 ELR12577.1 - 5.4e-51 170.6 21.7 7.2e-11 42.1 1.2 5.8 6 0 0 6 6 6 5 FF domain HEPN_RES_NTD1 PF18870.1 ELR12577.1 - 0.012 15.8 1.0 14 5.9 0.0 3.8 4 0 0 4 4 4 0 HEPN/RES N-terminal domain 1 Glyco_hydro_3 PF00933.21 ELR12578.1 - 3.4e-17 62.8 0.0 3.7e-17 62.7 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Glyco_hydro_3 PF00933.21 ELR12579.1 - 2e-25 89.9 0.0 2.6e-25 89.5 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Glyco_hydro_3_C PF01915.22 ELR12579.1 - 1.5e-08 34.8 0.0 3.3e-08 33.7 0.0 1.5 2 0 0 2 2 2 1 Glycosyl hydrolase family 3 C-terminal domain Pex19 PF04614.12 ELR12580.1 - 0.033 14.0 0.3 0.071 12.9 0.3 1.5 1 0 0 1 1 1 0 Pex19 protein family Fmp27_WPPW PF10359.9 ELR12580.1 - 0.08 11.8 0.1 0.11 11.3 0.1 1.2 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain Tricorn_C1 PF14684.6 ELR12580.1 - 0.087 12.9 0.0 0.22 11.6 0.0 1.6 1 0 0 1 1 1 0 Tricorn protease C1 domain DUF2897 PF11446.8 ELR12580.1 - 2.9 7.9 5.0 11 6.0 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2897) SLAC1 PF03595.17 ELR12582.1 - 7.4e-41 140.5 31.9 7.4e-41 140.5 31.9 2.2 2 1 0 2 2 2 1 Voltage-dependent anion channel DUF4395 PF14340.6 ELR12582.1 - 1.1e-13 51.7 3.6 1.1e-13 51.7 3.6 4.2 4 2 0 4 4 4 2 Domain of unknown function (DUF4395) Hemerythrin PF01814.23 ELR12582.1 - 9.4e-05 23.0 2.3 0.00018 22.2 2.3 1.4 1 0 0 1 1 1 1 Hemerythrin HHE cation binding domain PNISR PF15996.5 ELR12583.1 - 0.0028 17.9 10.4 0.0038 17.5 10.4 1.1 1 0 0 1 1 1 1 Arginine/serine-rich protein PNISR Mpp10 PF04006.12 ELR12583.1 - 0.0084 14.6 17.0 0.011 14.2 17.0 1.1 1 0 0 1 1 1 1 Mpp10 protein Apt1 PF10351.9 ELR12583.1 - 0.0088 14.9 4.7 0.011 14.6 4.7 1.1 1 0 0 1 1 1 1 Golgi-body localisation protein domain Presenilin PF01080.17 ELR12583.1 - 0.22 10.2 5.0 0.27 10.0 5.0 1.1 1 0 0 1 1 1 0 Presenilin PIEZO PF15917.5 ELR12583.1 - 1.2 8.6 8.1 1.9 7.9 8.1 1.3 1 0 0 1 1 1 0 Piezo SDA1 PF05285.12 ELR12583.1 - 1.4 8.2 30.0 2 7.8 30.0 1.1 1 0 0 1 1 1 0 SDA1 Hid1 PF12722.7 ELR12583.1 - 1.7 6.6 6.1 2.2 6.3 6.1 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein PPP4R2 PF09184.11 ELR12583.1 - 5.1 6.6 25.6 7.4 6.1 25.6 1.1 1 0 0 1 1 1 0 PPP4R2 KOG2701 PF09762.9 ELR12584.1 - 3.4e-59 200.1 4.4 4.5e-57 193.1 0.0 2.1 2 0 0 2 2 2 1 Coiled-coil domain-containing protein (DUF2037) DUF3347 PF11827.8 ELR12584.1 - 0.13 12.4 7.6 0.24 11.5 7.6 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3347) FAM76 PF16046.5 ELR12584.1 - 0.63 9.3 9.1 0.97 8.7 9.1 1.2 1 0 0 1 1 1 0 FAM76 protein FliD_N PF02465.18 ELR12584.1 - 0.83 10.4 7.2 2.5 8.9 3.0 2.5 1 1 1 2 2 2 0 Flagellar hook-associated protein 2 N-terminus NPR3 PF03666.13 ELR12584.1 - 0.92 8.2 7.5 0.066 12.0 2.6 1.5 2 0 0 2 2 2 0 Nitrogen Permease regulator of amino acid transport activity 3 Exonuc_VII_L PF02601.15 ELR12584.1 - 1 8.8 10.4 3 7.3 10.4 1.7 1 1 0 1 1 1 0 Exonuclease VII, large subunit DivIC PF04977.15 ELR12584.1 - 1.1 9.0 16.3 8 6.3 0.1 3.3 2 1 1 3 3 3 0 Septum formation initiator Fib_alpha PF08702.10 ELR12584.1 - 1.3 9.2 9.9 0.62 10.3 7.0 2.0 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family CENP-H PF05837.12 ELR12584.1 - 3.9 7.9 14.1 30 5.1 9.8 2.5 2 0 0 2 2 2 0 Centromere protein H (CENP-H) HemX PF04375.14 ELR12584.1 - 4.8 6.4 16.2 14 4.8 11.3 2.1 1 1 1 2 2 2 0 HemX, putative uroporphyrinogen-III C-methyltransferase CAS_CSE1 PF03378.15 ELR12585.1 - 1.3e-46 159.1 0.2 1.4e-46 158.9 0.2 1.0 1 0 0 1 1 1 1 CAS/CSE protein, C-terminus Spike_NTD PF16451.5 ELR12585.1 - 0.083 12.2 0.0 0.11 11.8 0.0 1.1 1 0 0 1 1 1 0 Spike glycoprotein N-terminal domain DUF2547 PF10818.8 ELR12585.1 - 0.13 13.2 1.5 0.54 11.2 0.0 2.4 3 0 0 3 3 3 0 Protein of unknown function (DUF2547) Ribonuc_red_lgC PF02867.15 ELR12586.1 - 5.5e-11 41.7 0.0 5.9e-11 41.6 0.0 1.0 1 0 0 1 1 1 1 Ribonucleotide reductase, barrel domain DNA_pol_B_3 PF08408.10 ELR12586.1 - 0.048 13.8 0.0 0.054 13.7 0.0 1.2 1 0 0 1 1 1 0 DNA polymerase family B viral insert KaiA PF07688.12 ELR12586.1 - 0.091 12.9 0.0 0.1 12.7 0.0 1.0 1 0 0 1 1 1 0 KaiA C-terminal domain Ank_4 PF13637.6 ELR12587.1 - 2.5e-10 40.7 4.1 0.22 12.2 0.1 6.3 3 3 3 6 6 6 4 Ankyrin repeats (many copies) Ank_2 PF12796.7 ELR12587.1 - 3.5e-06 27.5 0.1 1.7 9.3 0.0 4.3 1 1 4 6 6 6 3 Ankyrin repeats (3 copies) Ank_5 PF13857.6 ELR12587.1 - 0.007 16.7 7.8 27 5.2 0.0 7.0 7 2 2 9 9 9 1 Ankyrin repeats (many copies) CXCXC PF03128.14 ELR12587.1 - 2 9.0 8.5 77 4.1 0.1 4.8 5 0 0 5 5 5 0 CXCXC repeat BclA_C PF18573.1 ELR12589.1 - 0.0085 16.0 0.8 0.0085 16.0 0.8 3.3 4 1 0 5 5 5 1 BclA C-terminal domain BTB_2 PF02214.22 ELR12591.1 - 1.1e-11 44.9 0.0 1.8e-11 44.2 0.0 1.3 1 0 0 1 1 1 1 BTB/POZ domain Pkinase_Tyr PF07714.17 ELR12594.1 - 1.8e-11 43.8 0.1 2.8e-11 43.2 0.1 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ELR12594.1 - 2.2e-09 37.1 0.1 4.1e-09 36.2 0.0 1.5 2 0 0 2 2 2 1 Protein kinase domain Guanylate_cyc PF00211.20 ELR12594.1 - 0.0017 18.0 0.1 0.0028 17.3 0.1 1.4 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain ABC_tran PF00005.27 ELR12595.1 - 1.6e-08 35.2 0.0 1.8e-08 35.0 0.0 1.3 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 ELR12595.1 - 9.6e-05 22.3 0.0 0.00014 21.8 0.0 1.2 1 0 0 1 1 1 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 ELR12595.1 - 0.00046 20.8 0.0 0.00071 20.1 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 ELR12595.1 - 0.00049 20.5 0.0 0.0008 19.8 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain SRP54 PF00448.22 ELR12595.1 - 0.00083 19.0 0.3 0.0015 18.2 0.3 1.4 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain DUF2813 PF11398.8 ELR12595.1 - 0.0017 17.7 0.0 0.0024 17.2 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2813) NACHT PF05729.12 ELR12595.1 - 0.0019 18.1 0.1 0.0022 17.9 0.1 1.4 1 1 0 1 1 1 1 NACHT domain AAA_29 PF13555.6 ELR12595.1 - 0.0019 17.9 0.0 0.0046 16.7 0.0 1.7 1 1 0 1 1 1 1 P-loop containing region of AAA domain AAA_30 PF13604.6 ELR12595.1 - 0.0031 17.3 0.1 0.0045 16.7 0.1 1.4 1 0 0 1 1 1 1 AAA domain AAA_15 PF13175.6 ELR12595.1 - 0.0042 16.9 0.0 0.0056 16.4 0.0 1.3 1 1 0 1 1 1 1 AAA ATPase domain ATP-synt_ab PF00006.25 ELR12595.1 - 0.0067 16.1 0.0 0.008 15.8 0.0 1.3 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain AAA_22 PF13401.6 ELR12595.1 - 0.0076 16.5 0.0 0.015 15.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain MeaB PF03308.16 ELR12595.1 - 0.011 14.8 0.1 0.025 13.6 0.0 1.6 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Bac_DnaA PF00308.18 ELR12595.1 - 0.022 14.6 0.0 0.032 14.1 0.0 1.3 1 0 0 1 1 1 0 Bacterial dnaA protein RsgA_GTPase PF03193.16 ELR12595.1 - 0.027 14.4 0.0 0.042 13.8 0.0 1.3 1 0 0 1 1 1 0 RsgA GTPase PduV-EutP PF10662.9 ELR12595.1 - 0.03 14.1 0.0 0.048 13.4 0.0 1.4 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation AAA_25 PF13481.6 ELR12595.1 - 0.046 13.3 0.2 0.26 10.8 0.1 2.0 1 1 0 1 1 1 0 AAA domain MMR_HSR1 PF01926.23 ELR12595.1 - 0.048 13.8 0.1 0.12 12.4 0.0 1.9 1 1 1 2 2 2 0 50S ribosome-binding GTPase Roc PF08477.13 ELR12595.1 - 0.055 13.7 0.0 0.094 12.9 0.0 1.4 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase SMC_N PF02463.19 ELR12595.1 - 0.057 12.8 0.0 0.27 10.6 0.0 1.9 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain AAA_7 PF12775.7 ELR12595.1 - 0.064 12.8 0.0 0.1 12.1 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region KAP_NTPase PF07693.14 ELR12595.1 - 0.068 12.4 0.0 0.092 12.0 0.0 1.2 1 0 0 1 1 1 0 KAP family P-loop domain AAA_28 PF13521.6 ELR12595.1 - 0.079 13.2 0.3 0.16 12.2 0.2 1.7 1 1 0 1 1 1 0 AAA domain AAA_13 PF13166.6 ELR12595.1 - 0.087 11.5 0.0 0.12 10.9 0.0 1.3 1 0 0 1 1 1 0 AAA domain GTP_EFTU PF00009.27 ELR12595.1 - 0.1 12.1 0.0 0.15 11.6 0.0 1.2 1 0 0 1 1 1 0 Elongation factor Tu GTP binding domain TsaE PF02367.17 ELR12595.1 - 0.11 12.5 0.0 0.19 11.7 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_18 PF13238.6 ELR12595.1 - 0.14 12.7 0.0 0.24 11.9 0.0 1.5 1 1 0 1 1 1 0 AAA domain AAA_24 PF13479.6 ELR12595.1 - 0.16 11.7 0.0 0.19 11.4 0.0 1.4 1 1 0 1 1 1 0 AAA domain ANTH PF07651.16 ELR12596.1 - 9.3e-11 41.2 3.1 9.3e-11 41.2 3.1 1.9 2 0 0 2 2 2 1 ANTH domain Pkinase PF00069.25 ELR12597.1 - 4.1e-46 157.5 0.0 5.4e-46 157.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR12597.1 - 2.7e-23 82.6 0.0 3.7e-23 82.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ELR12597.1 - 0.00011 21.6 0.0 0.011 15.1 0.0 2.3 2 1 0 2 2 2 2 Kinase-like Pkinase_fungal PF17667.1 ELR12597.1 - 0.0076 15.1 0.1 0.014 14.2 0.1 1.5 1 1 0 1 1 1 1 Fungal protein kinase Rap_GAP PF02145.15 ELR12598.1 - 3.2e-49 167.0 0.0 5.8e-49 166.2 0.0 1.4 1 0 0 1 1 1 1 Rap/ran-GAP LRR_8 PF13855.6 ELR12598.1 - 1.2e-15 56.9 16.5 1.6e-08 34.2 3.0 3.8 1 1 3 4 4 4 4 Leucine rich repeat LRR_4 PF12799.7 ELR12598.1 - 3.4e-12 46.4 23.5 1.3e-06 28.6 0.4 4.8 1 1 5 6 6 6 5 Leucine Rich repeats (2 copies) SH2 PF00017.24 ELR12598.1 - 8.5e-06 25.8 0.1 5.1e-05 23.3 0.0 2.3 2 0 0 2 2 2 1 SH2 domain LRR_1 PF00560.33 ELR12598.1 - 4.8e-05 23.3 12.4 5.8 7.9 0.1 7.1 7 0 0 7 7 7 1 Leucine Rich Repeat IBP39 PF11422.8 ELR12598.1 - 0.049 13.4 0.0 0.097 12.4 0.0 1.4 1 0 0 1 1 1 0 Initiator binding protein 39 kDa LRR_6 PF13516.6 ELR12598.1 - 0.08 13.0 14.3 0.16 12.1 0.1 4.9 6 0 0 6 6 6 0 Leucine Rich repeat LRR_9 PF14580.6 ELR12598.1 - 0.15 11.6 4.9 3.4 7.1 0.4 2.4 1 1 0 2 2 2 0 Leucine-rich repeat SET PF00856.28 ELR12599.1 - 0.0039 17.6 0.0 0.0082 16.5 0.0 1.7 2 0 0 2 2 2 1 SET domain DUF3246 PF11596.8 ELR12601.1 - 0.032 13.7 0.4 0.069 12.6 0.4 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3246) DUF624 PF04854.14 ELR12602.1 - 0.2 11.8 0.0 2 8.6 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function, DUF624 Amidohydro_1 PF01979.20 ELR12604.1 - 8.6e-33 114.1 0.0 1e-32 113.8 0.0 1.1 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 ELR12604.1 - 2.5e-11 43.7 0.3 1.7e-05 24.5 0.0 3.1 2 1 1 3 3 3 3 Amidohydrolase family TatD_DNase PF01026.21 ELR12604.1 - 0.006 16.0 0.1 0.013 14.9 0.1 1.5 1 1 0 1 1 1 1 TatD related DNase SANT_DAMP1_like PF16282.5 ELR12604.1 - 0.13 12.5 0.0 0.27 11.4 0.0 1.4 1 0 0 1 1 1 0 SANT/Myb-like domain of DAMP1 Ank_2 PF12796.7 ELR12605.1 - 5.1e-18 65.4 0.1 5.2e-08 33.4 0.1 2.7 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ELR12605.1 - 5.2e-17 62.0 0.2 1.9e-06 28.3 0.1 4.4 3 1 1 4 4 4 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 ELR12605.1 - 3.5e-16 59.1 0.4 4.9e-09 36.3 0.0 3.4 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.30 ELR12605.1 - 4.2e-16 58.6 1.6 1e-05 25.8 0.0 4.7 5 0 0 5 5 5 2 Ankyrin repeat Ank_3 PF13606.6 ELR12605.1 - 5.1e-14 51.0 0.7 0.00023 21.4 0.0 5.2 6 0 0 6 6 6 2 Ankyrin repeat Methyltransf_11 PF08241.12 ELR12606.1 - 7.8e-13 48.9 0.0 2.2e-12 47.5 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 ELR12606.1 - 2.1e-10 41.1 0.1 3.7e-10 40.4 0.1 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ELR12606.1 - 8.8e-06 26.4 0.1 2.9e-05 24.7 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 ELR12606.1 - 0.00022 21.1 0.0 0.00033 20.5 0.0 1.5 2 0 0 2 2 2 1 Methyltransferase domain RrnaAD PF00398.20 ELR12606.1 - 0.0094 15.0 0.0 0.015 14.4 0.0 1.2 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Methyltransf_32 PF13679.6 ELR12606.1 - 0.015 15.3 0.0 0.019 15.0 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain PCMT PF01135.19 ELR12606.1 - 0.032 14.0 0.0 0.051 13.3 0.0 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) MTS PF05175.14 ELR12606.1 - 0.14 11.7 0.0 0.21 11.1 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_31 PF13847.6 ELR12606.1 - 0.15 11.8 0.0 0.22 11.3 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Urocanase PF01175.18 ELR12607.1 - 3.7e-90 301.2 0.0 5.9e-90 300.5 0.0 1.3 1 0 0 1 1 1 1 Urocanase Rossmann-like domain Urocanase_C PF17392.2 ELR12607.1 - 5.5e-80 267.4 2.9 9.7e-80 266.6 2.9 1.4 1 0 0 1 1 1 1 Urocanase C-terminal domain Urocanase_N PF17391.2 ELR12607.1 - 1.2e-58 196.3 0.9 2.8e-57 191.9 0.2 2.3 2 0 0 2 2 2 1 Urocanase N-terminal domain Acyl-CoA_dh_1 PF00441.24 ELR12609.1 - 1.3e-36 126.0 4.3 1.7e-36 125.6 4.3 1.2 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 ELR12609.1 - 1.6e-22 79.5 0.0 2.8e-22 78.7 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_N PF02771.16 ELR12609.1 - 9.4e-15 55.3 0.0 1.6e-14 54.5 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_2 PF08028.11 ELR12609.1 - 6.6e-12 45.9 6.5 9.5e-12 45.3 6.5 1.2 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain DUF3986 PF13143.6 ELR12609.1 - 0.081 13.9 0.0 0.23 12.5 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3986) HpaB_N PF11794.8 ELR12609.1 - 0.18 11.5 0.1 3.3 7.3 0.0 2.1 2 0 0 2 2 2 0 4-hydroxyphenylacetate 3-hydroxylase N terminal WD40 PF00400.32 ELR12612.1 - 6.7e-17 61.6 7.5 0.0043 17.9 0.1 6.5 6 0 0 6 6 6 6 WD domain, G-beta repeat F-box-like PF12937.7 ELR12612.1 - 1.8e-08 34.1 0.1 3.3e-08 33.3 0.1 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ELR12612.1 - 2.2e-05 24.2 0.1 3.5e-05 23.5 0.1 1.3 1 0 0 1 1 1 1 F-box domain ANAPC4_WD40 PF12894.7 ELR12612.1 - 0.011 16.0 0.0 2.4 8.5 0.0 3.0 3 0 0 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain SKG6 PF08693.10 ELR12613.1 - 0.0033 16.8 12.8 0.0046 16.3 9.6 2.5 2 0 0 2 2 2 1 Transmembrane alpha-helix domain BTB PF00651.31 ELR12614.1 - 1.5e-23 83.1 0.5 1.3e-19 70.4 0.0 2.7 2 1 1 3 3 3 2 BTB/POZ domain BACK PF07707.15 ELR12614.1 - 4.3e-17 62.1 0.3 1.2e-16 60.6 0.2 1.8 2 0 0 2 2 2 1 BTB And C-terminal Kelch UBA_4 PF14555.6 ELR12614.1 - 1.6e-12 47.0 0.2 9.2e-11 41.4 0.1 2.4 2 0 0 2 2 2 1 UBA-like domain SPRY PF00622.28 ELR12614.1 - 4e-10 39.8 0.6 6.9e-10 39.1 0.6 1.3 1 0 0 1 1 1 1 SPRY domain DASH_Ask1 PF08655.10 ELR12614.1 - 0.016 15.1 0.0 0.043 13.7 0.0 1.7 1 0 0 1 1 1 0 DASH complex subunit Ask1 PLDc_2 PF13091.6 ELR12616.1 - 3.1e-10 40.1 0.0 0.00016 21.6 0.0 3.4 4 0 0 4 4 4 2 PLD-like domain PLDc PF00614.22 ELR12616.1 - 1.4e-08 34.6 0.0 0.0015 18.6 0.0 2.5 2 0 0 2 2 2 2 Phospholipase D Active site motif Pkinase PF00069.25 ELR12617.1 - 4.5e-64 216.4 0.1 5.3e-64 216.1 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR12617.1 - 3.4e-19 69.1 0.0 4.9e-19 68.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 ELR12617.1 - 1.5e-08 34.8 0.0 2.3e-06 27.7 0.1 2.4 1 1 1 2 2 2 2 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 ELR12617.1 - 0.0039 16.0 0.0 0.0077 15.0 0.0 1.4 2 0 0 2 2 2 1 Fungal protein kinase Choline_kinase PF01633.20 ELR12617.1 - 0.054 13.1 0.1 0.12 12.0 0.1 1.5 1 0 0 1 1 1 0 Choline/ethanolamine kinase Kdo PF06293.14 ELR12617.1 - 0.055 12.8 0.2 0.1 11.9 0.2 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Methyltransf_2 PF00891.18 ELR12618.1 - 0.012 15.0 0.0 0.013 14.8 0.0 1.1 1 0 0 1 1 1 0 O-methyltransferase domain Got1 PF04178.12 ELR12619.1 - 4.5e-07 30.3 9.9 2.4e-06 27.9 9.9 1.9 1 1 0 1 1 1 1 Got1/Sft2-like family RhoGAP PF00620.27 ELR12620.1 - 6.4e-47 159.2 0.0 9.7e-47 158.6 0.0 1.3 1 0 0 1 1 1 1 RhoGAP domain PH PF00169.29 ELR12620.1 - 1.8e-12 47.7 0.0 3.4e-12 46.8 0.0 1.5 1 0 0 1 1 1 1 PH domain Rad60-SLD PF11976.8 ELR12620.1 - 0.0027 17.5 0.0 0.012 15.4 0.0 2.1 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like FERM_f0 PF16511.5 ELR12620.1 - 0.0031 17.8 0.0 0.0031 17.8 0.0 3.1 3 1 1 4 4 4 1 N-terminal or F0 domain of Talin-head FERM DUF1708 PF08101.11 ELR12620.1 - 0.0036 16.5 0.0 0.0058 15.8 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF1708) PH_3 PF14593.6 ELR12620.1 - 0.031 14.4 0.0 0.093 12.8 0.0 1.8 1 0 0 1 1 1 0 PH domain Tub PF01167.18 ELR12620.1 - 0.065 13.0 0.0 0.1 12.4 0.0 1.3 1 0 0 1 1 1 0 Tub family PH_6 PF15406.6 ELR12620.1 - 0.11 12.8 0.0 0.24 11.7 0.0 1.5 1 0 0 1 1 1 0 Pleckstrin homology domain SPA PF08616.10 ELR12621.1 - 6.3e-19 68.0 0.0 1.2e-18 67.1 0.0 1.5 1 0 0 1 1 1 1 Stabilization of polarity axis Afi1 PF07792.12 ELR12621.1 - 5.5e-17 62.5 0.0 1.4e-16 61.2 0.0 1.7 1 0 0 1 1 1 1 Docking domain of Afi1 for Arf3 in vesicle trafficking Avl9 PF09794.9 ELR12621.1 - 2e-10 39.9 0.3 0.0073 15.1 0.0 3.4 2 1 1 3 3 3 3 Transport protein Avl9 DENN PF02141.21 ELR12621.1 - 0.01 15.8 0.7 5.4 6.9 0.1 2.7 1 1 1 2 2 2 0 DENN (AEX-3) domain bcl-2I13 PF12201.8 ELR12621.1 - 0.086 12.7 0.1 0.21 11.4 0.1 1.6 1 0 0 1 1 1 0 Bcl2-interacting killer, BH3-domain containing Pkinase PF00069.25 ELR12622.1 - 1.3e-67 227.9 0.0 3.2e-67 226.7 0.0 1.7 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR12622.1 - 1.6e-30 106.3 0.0 4e-30 105.0 0.0 1.6 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ELR12622.1 - 0.0002 20.8 0.0 0.00059 19.2 0.0 1.7 2 0 0 2 2 2 1 Kinase-like Haspin_kinase PF12330.8 ELR12622.1 - 0.00067 18.7 0.2 0.001 18.1 0.2 1.2 1 0 0 1 1 1 1 Haspin like kinase domain FTA2 PF13095.6 ELR12622.1 - 0.00071 19.3 0.5 0.011 15.3 0.1 2.4 2 0 0 2 2 2 1 Kinetochore Sim4 complex subunit FTA2 Pkinase_fungal PF17667.1 ELR12622.1 - 0.042 12.6 0.3 7.8 5.2 0.4 2.4 2 0 0 2 2 2 0 Fungal protein kinase SIN1_PH PF16979.5 ELR12622.1 - 0.12 12.7 0.5 0.37 11.1 0.1 2.0 2 1 0 2 2 2 0 SAPK-interacting protein 1 (Sin1), Pleckstrin-homology PK PF00224.21 ELR12623.1 - 2.2e-117 391.9 3.9 3e-117 391.4 3.9 1.1 1 0 0 1 1 1 1 Pyruvate kinase, barrel domain PK_C PF02887.16 ELR12623.1 - 5.8e-19 68.4 0.0 1.9e-18 66.8 0.0 1.9 1 0 0 1 1 1 1 Pyruvate kinase, alpha/beta domain HpcH_HpaI PF03328.14 ELR12623.1 - 0.00081 18.6 1.3 0.0063 15.7 0.2 2.8 3 1 0 3 3 3 1 HpcH/HpaI aldolase/citrate lyase family Glyco_hydro_3_C PF01915.22 ELR12623.1 - 0.14 12.1 0.1 0.33 10.9 0.1 1.5 1 1 0 1 1 1 0 Glycosyl hydrolase family 3 C-terminal domain DENN PF02141.21 ELR12624.1 - 4.9e-52 176.6 2.6 7.8e-52 175.9 2.6 1.3 1 0 0 1 1 1 1 DENN (AEX-3) domain uDENN PF03456.18 ELR12624.1 - 2.8e-11 44.0 1.8 1.3e-10 41.8 1.8 2.2 1 0 0 1 1 1 1 uDENN domain dDENN PF03455.19 ELR12624.1 - 1.6e-08 34.4 0.1 5.8e-08 32.6 0.1 2.0 1 0 0 1 1 1 1 dDENN domain SPA PF08616.10 ELR12624.1 - 0.084 12.8 0.1 0.19 11.7 0.1 1.6 1 0 0 1 1 1 0 Stabilization of polarity axis DUF2514 PF10721.9 ELR12624.1 - 0.13 12.2 1.2 0.26 11.3 1.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2514) Med7 PF05983.11 ELR12625.1 - 6.2e-42 143.8 9.4 1.8e-40 139.1 9.4 2.3 1 1 0 1 1 1 1 MED7 protein EamA PF00892.20 ELR12626.1 - 0.0009 19.4 16.1 0.0067 16.6 16.1 1.9 1 1 0 1 1 1 1 EamA-like transporter family Strabismus PF06638.11 ELR12626.1 - 0.12 11.0 0.4 0.17 10.5 0.4 1.1 1 0 0 1 1 1 0 Strabismus protein DUF1774 PF08611.10 ELR12626.1 - 0.2 12.0 3.1 0.12 12.7 0.4 1.9 2 0 0 2 2 2 0 Fungal protein of unknown function (DUF1774) PRKCSH-like PF12999.7 ELR12627.1 - 1.3e-21 77.2 2.0 1.9e-21 76.6 2.0 1.2 1 0 0 1 1 1 1 Glucosidase II beta subunit-like Ldl_recept_a PF00057.18 ELR12627.1 - 0.45 10.8 14.1 0.45 10.8 5.7 2.5 2 0 0 2 2 2 0 Low-density lipoprotein receptor domain class A S1 PF00575.23 ELR12628.1 - 1.5e-81 268.8 33.0 4.1e-13 49.5 0.0 15.3 14 2 1 15 15 15 14 S1 RNA binding domain TPR_14 PF13428.6 ELR12628.1 - 2.1e-09 37.4 0.2 0.0038 17.9 0.0 5.7 2 2 4 6 6 6 1 Tetratricopeptide repeat Suf PF05843.14 ELR12628.1 - 2.2e-08 34.4 0.1 2.2e-08 34.4 0.1 4.4 2 1 3 5 5 5 3 Suppressor of forked protein (Suf) TPR_19 PF14559.6 ELR12628.1 - 0.00021 21.7 0.0 0.29 11.6 0.0 3.6 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_16 PF13432.6 ELR12628.1 - 0.001 19.6 0.0 0.41 11.3 0.0 3.1 3 0 0 3 3 3 1 Tetratricopeptide repeat DUF3592 PF12158.8 ELR12628.1 - 0.096 12.7 0.0 91 3.1 0.0 4.3 5 1 0 5 5 5 0 Protein of unknown function (DUF3592) Ras PF00071.22 ELR12629.1 - 9.6e-52 174.9 0.0 1.1e-51 174.7 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR12629.1 - 3.9e-22 78.7 0.0 5.3e-22 78.3 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR12629.1 - 1.6e-09 37.4 0.0 2.1e-09 37.1 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 ELR12629.1 - 0.00094 19.2 0.0 0.0013 18.8 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase PduV-EutP PF10662.9 ELR12629.1 - 0.0052 16.5 0.0 0.091 12.5 0.0 2.6 1 1 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation PepSY_2 PF13670.6 ELR12630.1 - 0.1 12.6 3.1 0.11 12.5 1.9 1.6 1 1 1 2 2 2 0 Peptidase propeptide and YPEB domain Big_2 PF02368.18 ELR12631.1 - 1.1e-16 60.5 36.3 4e-06 26.6 0.1 10.4 10 2 1 11 11 11 4 Bacterial Ig-like domain (group 2) T2SS-T3SS_pil_N PF13629.6 ELR12631.1 - 0.0058 16.3 5.5 13 5.6 0.1 5.7 4 0 0 4 4 4 2 Pilus formation protein N terminal region Phage_CI_repr PF07022.13 ELR12631.1 - 0.069 13.3 0.0 7.2 6.8 0.0 3.3 3 1 0 3 3 3 0 Bacteriophage CI repressor helix-turn-helix domain TPR_8 PF13181.6 ELR12632.1 - 6.8e-09 35.2 3.2 0.011 15.9 0.0 4.4 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.17 ELR12632.1 - 1.4e-08 34.2 4.3 0.00068 19.6 0.2 4.3 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_1 PF00515.28 ELR12632.1 - 5.8e-08 32.2 1.3 0.00044 20.0 0.1 3.6 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_11 PF13414.6 ELR12632.1 - 6.8e-06 25.7 0.7 0.015 14.9 0.0 3.5 3 1 1 4 4 4 2 TPR repeat TPR_14 PF13428.6 ELR12632.1 - 1.9e-05 25.1 4.0 0.0072 17.1 0.1 4.6 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_15 PF13429.6 ELR12632.1 - 2.6e-05 23.6 0.3 8.9e-05 21.8 0.2 1.9 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.6 ELR12632.1 - 0.00039 20.6 3.3 0.11 12.8 0.4 3.7 3 1 1 4 4 4 1 Tetratricopeptide repeat SHNi-TPR PF10516.9 ELR12632.1 - 0.0005 19.5 0.1 0.0014 18.0 0.1 1.8 1 0 0 1 1 1 1 SHNi-TPR TPR_19 PF14559.6 ELR12632.1 - 0.0014 19.1 7.3 0.0077 16.7 0.1 3.9 4 1 0 4 4 4 1 Tetratricopeptide repeat TPR_16 PF13432.6 ELR12632.1 - 0.0043 17.7 0.4 0.066 13.9 0.1 3.0 3 0 0 3 3 2 1 Tetratricopeptide repeat ANAPC3 PF12895.7 ELR12632.1 - 0.0049 17.1 2.0 3.7 7.8 0.1 3.3 3 0 0 3 3 3 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 PF13176.6 ELR12632.1 - 0.006 16.5 0.1 0.039 14.0 0.0 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat SNAP PF14938.6 ELR12632.1 - 0.053 12.9 0.0 0.11 12.0 0.0 1.4 1 0 0 1 1 1 0 Soluble NSF attachment protein, SNAP Nucleoporin_FG PF13634.6 ELR12633.1 - 7.7e-07 29.9 14.3 7.7e-07 29.9 14.3 14.9 9 4 3 13 13 13 2 Nucleoporin FG repeat region YL1 PF05764.13 ELR12633.1 - 0.00013 22.2 30.0 0.018 15.2 23.6 2.7 2 0 0 2 2 2 2 YL1 nuclear protein Nop14 PF04147.12 ELR12633.1 - 0.00035 18.9 31.1 0.00035 18.9 31.1 2.1 2 0 0 2 2 2 1 Nop14-like family SDA1 PF05285.12 ELR12633.1 - 0.0036 16.8 34.2 0.038 13.4 31.2 2.5 2 0 0 2 2 2 1 SDA1 DUF2616 PF11077.8 ELR12633.1 - 0.092 12.5 14.4 5 6.8 0.4 4.1 4 0 0 4 4 4 0 Protein of unknown function (DUF2616) zf-RanBP PF00641.18 ELR12633.1 - 0.11 11.8 48.7 0.91 8.9 5.3 4.4 4 0 0 4 4 4 0 Zn-finger in Ran binding protein and others Apolipoprotein PF01442.18 ELR12634.1 - 0.0001 22.3 2.3 0.00018 21.4 2.3 1.4 1 0 0 1 1 1 1 Apolipoprotein A1/A4/E domain HypA PF01155.19 ELR12634.1 - 0.0053 16.8 0.4 0.012 15.7 0.4 1.6 1 1 0 1 1 1 1 Hydrogenase/urease nickel incorporation, metallochaperone, hypA YtxH PF12732.7 ELR12634.1 - 0.017 15.7 3.9 0.017 15.7 3.9 2.7 1 1 2 3 3 3 0 YtxH-like protein Elf1 PF05129.13 ELR12634.1 - 0.038 14.0 0.0 5.4 7.1 0.0 2.6 2 0 0 2 2 2 0 Transcription elongation factor Elf1 like Lar_restr_allev PF14354.6 ELR12634.1 - 0.047 14.1 1.1 0.29 11.5 0.6 2.5 2 1 0 2 2 1 0 Restriction alleviation protein Lar Ribosomal_S27e PF01667.17 ELR12634.1 - 0.047 13.4 0.3 8 6.3 0.0 2.5 2 0 0 2 2 2 0 Ribosomal protein S27 Herpes_UL14 PF03580.14 ELR12634.1 - 0.051 13.8 0.7 0.089 13.0 0.7 1.3 1 0 0 1 1 1 0 Herpesvirus UL14-like protein DUF1195 PF06708.11 ELR12634.1 - 0.062 13.1 0.0 0.18 11.5 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1195) zf-C4_Topoisom PF01396.19 ELR12634.1 - 0.1 12.4 1.9 6.2 6.7 0.1 2.6 2 0 0 2 2 2 0 Topoisomerase DNA binding C4 zinc finger CpXC PF14353.6 ELR12634.1 - 0.11 12.6 1.7 0.57 10.2 0.3 2.7 2 1 0 2 2 2 0 CpXC protein zf-ACC PF17848.1 ELR12634.1 - 0.11 12.6 3.4 4.3 7.5 0.5 2.7 2 0 0 2 2 2 0 Acetyl-coA carboxylase zinc finger domain ADD_ATRX PF17981.1 ELR12634.1 - 0.13 12.1 0.3 0.13 12.1 0.3 1.9 2 0 0 2 2 2 0 Cysteine Rich ADD domain Zn-ribbon_8 PF09723.10 ELR12634.1 - 0.2 11.8 0.5 17 5.6 0.1 2.8 2 0 0 2 2 2 0 Zinc ribbon domain DUF1451 PF07295.11 ELR12634.1 - 0.34 10.9 6.4 0.18 11.9 2.0 2.5 3 0 0 3 3 3 0 Zinc-ribbon containing domain zf-RRN7 PF11781.8 ELR12634.1 - 0.36 10.6 1.6 0.62 9.8 0.1 2.1 2 0 0 2 2 2 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 HEPN_AbiU2 PF18734.1 ELR12634.1 - 0.4 10.2 5.8 26 4.2 5.8 2.6 1 1 0 1 1 1 0 AbiU2 zf-ribbon_3 PF13248.6 ELR12634.1 - 1.1 8.7 7.1 1.5 8.3 0.3 2.8 3 0 0 3 3 3 0 zinc-ribbon domain Endotoxin_C2 PF18449.1 ELR12634.1 - 1.3 9.4 4.4 0.55 10.6 0.3 2.3 2 0 0 2 2 2 0 Delta endotoxin RRF PF01765.19 ELR12634.1 - 1.5 8.8 8.9 0.14 12.2 2.7 2.0 1 1 1 2 2 2 0 Ribosome recycling factor DUF3461 PF11944.8 ELR12634.1 - 2.2 8.4 10.1 5.9 7.0 3.2 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF3461) zinc_ribbon_2 PF13240.6 ELR12634.1 - 4.3 7.2 8.8 5.1 7.0 0.3 2.8 3 0 0 3 3 3 0 zinc-ribbon domain Methyltransf_2 PF00891.18 ELR12635.1 - 2.1e-30 105.6 0.0 2.8e-30 105.2 0.0 1.2 1 0 0 1 1 1 1 O-methyltransferase domain Dimerisation2 PF16864.5 ELR12635.1 - 2.9e-10 40.0 0.0 1.4e-09 37.7 0.0 2.1 2 0 0 2 2 2 1 Dimerisation domain Dimerisation PF08100.11 ELR12635.1 - 0.00013 21.9 0.0 0.00035 20.5 0.0 1.8 1 0 0 1 1 1 1 Dimerisation domain Fungal_KA1 PF16797.5 ELR12637.1 - 0.088 12.5 0.0 0.22 11.2 0.0 1.6 1 1 0 1 1 1 0 Fungal kinase associated-1 domain TBPIP PF07106.13 ELR12638.1 - 2.9e-18 65.5 0.7 2.9e-18 65.5 0.7 2.0 2 0 0 2 2 1 1 TBPIP/Hop2 winged helix domain Nup54 PF13874.6 ELR12638.1 - 0.0043 17.2 0.3 0.0086 16.2 0.3 1.5 1 1 0 1 1 1 1 Nucleoporin complex subunit 54 CENP-F_leu_zip PF10473.9 ELR12638.1 - 0.0057 16.7 6.6 0.13 12.2 0.1 2.5 1 1 1 2 2 2 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF5082 PF16888.5 ELR12638.1 - 0.0072 16.6 2.8 0.46 10.8 0.1 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF5082) Laminin_II PF06009.12 ELR12638.1 - 0.0075 16.3 0.5 0.017 15.1 0.5 1.5 1 0 0 1 1 1 1 Laminin Domain II CCDC92 PF14916.6 ELR12638.1 - 0.009 15.8 0.5 0.96 9.3 0.1 2.4 2 0 0 2 2 2 1 Coiled-coil domain of unknown function KELK PF15796.5 ELR12638.1 - 0.014 15.8 3.8 0.04 14.4 3.8 1.7 1 0 0 1 1 1 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase LZ3wCH PF18517.1 ELR12638.1 - 0.016 15.3 2.0 0.029 14.5 0.2 2.5 2 0 0 2 2 1 0 Leucine zipper with capping helix domain UPF0242 PF06785.11 ELR12638.1 - 0.022 14.9 4.2 0.029 14.5 4.2 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Mto2_bdg PF12808.7 ELR12638.1 - 0.035 14.4 1.9 0.035 14.4 1.9 2.3 2 0 0 2 2 2 0 Micro-tubular organiser Mto1 C-term Mto2-binding region HALZ PF02183.18 ELR12638.1 - 0.045 14.0 0.4 2.8 8.2 0.1 2.7 2 0 0 2 2 2 0 Homeobox associated leucine zipper zf-C4H2 PF10146.9 ELR12638.1 - 0.067 13.5 2.7 0.1 12.9 2.7 1.4 1 0 0 1 1 1 0 Zinc finger-containing protein DUF4140 PF13600.6 ELR12638.1 - 0.097 13.1 2.8 7.9 7.0 0.0 2.5 1 1 1 2 2 2 0 N-terminal domain of unknown function (DUF4140) M PF02370.16 ELR12638.1 - 0.11 13.1 2.1 0.11 13.1 2.1 3.9 4 0 0 4 4 2 0 M protein repeat Herpes_BLRF2 PF05812.12 ELR12638.1 - 0.11 12.6 2.7 0.16 12.1 1.2 2.0 2 0 0 2 2 2 0 Herpesvirus BLRF2 protein PNK3P PF08645.11 ELR12638.1 - 0.12 12.1 0.5 0.17 11.6 0.5 1.4 1 1 0 1 1 1 0 Polynucleotide kinase 3 phosphatase YabA PF06156.13 ELR12638.1 - 0.14 12.8 1.5 0.3 11.7 1.1 1.8 1 1 0 1 1 1 0 Initiation control protein YabA ABC_tran_CTD PF16326.5 ELR12638.1 - 0.15 12.3 9.5 4.6 7.6 0.4 2.8 1 1 1 2 2 2 0 ABC transporter C-terminal domain DivIC PF04977.15 ELR12638.1 - 0.19 11.5 7.2 0.39 10.5 1.8 2.7 3 0 0 3 3 3 0 Septum formation initiator Golgin_A5 PF09787.9 ELR12638.1 - 0.24 10.8 4.2 0.31 10.5 4.2 1.2 1 0 0 1 1 1 0 Golgin subfamily A member 5 Spc24 PF08286.11 ELR12638.1 - 0.25 11.6 4.8 1.4 9.2 0.4 2.4 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 Cnn_1N PF07989.11 ELR12638.1 - 0.48 10.6 5.2 9 6.5 5.5 2.5 1 1 0 1 1 1 0 Centrosomin N-terminal motif 1 APG6_N PF17675.1 ELR12638.1 - 0.48 11.0 7.6 0.85 10.2 6.2 2.0 1 1 0 1 1 1 0 Apg6 coiled-coil region Spc7 PF08317.11 ELR12638.1 - 0.68 8.8 7.1 1.9 7.3 4.8 2.0 1 1 1 2 2 2 0 Spc7 kinetochore protein NYD-SP28_assoc PF14775.6 ELR12638.1 - 0.81 9.8 3.1 1.5 9.0 1.2 2.2 2 0 0 2 2 2 0 Sperm tail C-terminal domain Ax_dynein_light PF10211.9 ELR12638.1 - 0.93 9.4 6.7 1.6 8.6 2.9 2.3 1 1 1 2 2 2 0 Axonemal dynein light chain Val_tRNA-synt_C PF10458.9 ELR12638.1 - 1.1 9.6 10.3 12 6.2 0.2 3.7 3 1 0 3 3 3 0 Valyl tRNA synthetase tRNA binding arm ZapB PF06005.12 ELR12638.1 - 1.4 9.4 6.3 13 6.3 3.2 2.4 1 1 1 2 2 2 0 Cell division protein ZapB Cauli_DNA-bind PF03310.13 ELR12638.1 - 1.7 8.8 5.7 0.51 10.4 1.9 2.2 2 1 1 3 3 2 0 Caulimovirus DNA-binding protein DUF3811 PF11656.8 ELR12638.1 - 2.9 8.3 6.8 10 6.6 0.0 2.9 3 0 0 3 3 2 0 YjbD family (DUF3811) DUF724 PF05266.14 ELR12638.1 - 3.4 7.5 7.0 0.57 10.0 1.4 1.9 2 1 0 2 2 2 0 Protein of unknown function (DUF724) TMF_DNA_bd PF12329.8 ELR12638.1 - 3.9 7.5 13.5 2.2 8.4 8.8 2.6 1 1 3 4 4 4 0 TATA element modulatory factor 1 DNA binding RhoGAP PF00620.27 ELR12639.1 - 2.6e-39 134.5 0.0 5e-39 133.5 0.0 1.5 1 0 0 1 1 1 1 RhoGAP domain Synaptobrevin PF00957.21 ELR12640.1 - 8.5e-16 57.5 1.3 1.3e-15 56.9 1.3 1.3 1 0 0 1 1 1 1 Synaptobrevin Longin PF13774.6 ELR12640.1 - 2.8e-09 36.9 0.0 4.4e-09 36.3 0.0 1.3 1 0 0 1 1 1 1 Regulated-SNARE-like domain DUF5534 PF17686.1 ELR12640.1 - 0.017 15.4 0.0 0.026 14.8 0.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5534) Baculo_11_kDa PF06143.11 ELR12640.1 - 0.024 14.2 2.0 0.05 13.2 2.0 1.5 1 0 0 1 1 1 0 Baculovirus 11 kDa family GGACT PF06094.12 ELR12640.1 - 0.049 14.2 0.1 9.8 6.8 0.1 2.3 2 1 0 2 2 2 0 Gamma-glutamyl cyclotransferase, AIG2-like K_channel_TID PF07941.11 ELR12641.1 - 0.069 13.6 0.9 0.069 13.6 0.9 3.0 3 1 0 3 3 3 0 Potassium channel Kv1.4 tandem inactivation domain MAGE_N PF12440.8 ELR12641.1 - 0.41 11.4 14.0 1.5 9.6 14.0 1.9 1 1 0 1 1 1 0 Melanoma associated antigen family N terminal Jnk-SapK_ap_N PF09744.9 ELR12641.1 - 1.5 9.0 15.6 2.4 8.4 15.6 1.4 1 1 0 1 1 1 0 JNK_SAPK-associated protein-1 CorA PF01544.18 ELR12641.1 - 7.8 5.7 5.8 11 5.2 5.8 1.2 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein Avl9 PF09794.9 ELR12642.1 - 7.8e-75 251.9 0.0 1.7e-74 250.8 0.0 1.5 1 1 0 1 1 1 1 Transport protein Avl9 SPA PF08616.10 ELR12642.1 - 9.5e-09 35.2 0.0 0.0038 17.2 0.0 2.4 2 0 0 2 2 2 2 Stabilization of polarity axis DUF2347 PF09804.9 ELR12642.1 - 1.5e-07 31.4 0.0 0.00025 20.7 0.1 2.5 2 0 0 2 2 2 2 Uncharacterized conserved protein (DUF2347) PEMT PF04191.13 ELR12643.1 - 5.1e-34 116.8 3.4 5.1e-34 116.8 3.4 1.7 2 1 1 3 3 3 1 Phospholipid methyltransferase YbhQ PF11076.8 ELR12643.1 - 0.016 15.2 0.6 0.036 14.1 0.1 1.9 2 0 0 2 2 2 0 Putative inner membrane protein YbhQ E1_DerP2_DerF2 PF02221.15 ELR12644.1 - 3.9e-13 50.0 0.6 1e-11 45.4 0.3 2.5 1 1 1 2 2 2 1 ML domain LEAP-2 PF07359.11 ELR12644.1 - 0.15 11.9 0.2 0.3 11.0 0.2 1.5 1 0 0 1 1 1 0 Liver-expressed antimicrobial peptide 2 precursor (LEAP-2) Ank_2 PF12796.7 ELR12645.1 - 1.5e-24 86.4 0.8 3e-06 27.7 0.1 6.9 4 2 1 6 6 6 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ELR12645.1 - 9.9e-23 80.2 1.1 0.047 14.3 0.0 8.7 6 3 1 8 8 8 7 Ankyrin repeats (many copies) Ank_3 PF13606.6 ELR12645.1 - 9.5e-16 56.3 13.5 0.16 12.6 0.1 12.1 11 2 1 12 12 12 3 Ankyrin repeat Ank PF00023.30 ELR12645.1 - 5.4e-12 45.6 8.5 1.3 9.5 0.0 9.1 8 1 1 9 9 9 4 Ankyrin repeat F-box-like PF12937.7 ELR12645.1 - 1.3e-10 40.9 0.4 2.8e-10 39.9 0.4 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ELR12645.1 - 2.5e-08 33.6 0.3 5.6e-08 32.5 0.3 1.6 1 0 0 1 1 1 1 F-box domain Ank_5 PF13857.6 ELR12645.1 - 6.2e-08 32.8 12.2 0.015 15.6 0.1 8.1 8 2 2 10 10 10 2 Ankyrin repeats (many copies) Cnl2_NKP2 PF09447.10 ELR12645.1 - 0.16 12.2 0.8 0.6 10.3 0.2 2.4 2 0 0 2 2 2 0 Cnl2/NKP2 family protein DUF3446 PF11928.8 ELR12645.1 - 0.94 9.8 16.9 5.5 7.4 13.5 2.7 2 0 0 2 2 2 0 Early growth response N-terminal domain ADP_ribosyl_GH PF03747.14 ELR12646.1 - 1.7e-64 218.3 2.7 2.6e-64 217.8 2.7 1.3 1 0 0 1 1 1 1 ADP-ribosylglycohydrolase zf-UBP PF02148.19 ELR12646.1 - 2.5e-15 56.5 13.0 5.2e-15 55.5 13.0 1.6 1 0 0 1 1 1 1 Zn-finger in ubiquitin-hydrolases and other protein Sod_Fe_C PF02777.18 ELR12647.1 - 3.3e-39 133.2 0.2 1.1e-38 131.5 0.0 1.9 3 0 0 3 3 3 1 Iron/manganese superoxide dismutases, C-terminal domain Sod_Fe_N PF00081.22 ELR12647.1 - 3.6e-25 88.2 1.9 8e-25 87.1 1.9 1.6 1 1 0 1 1 1 1 Iron/manganese superoxide dismutases, alpha-hairpin domain ocr PF08684.10 ELR12647.1 - 0.16 12.4 0.4 0.37 11.3 0.0 1.7 2 0 0 2 2 2 0 DNA mimic ocr Myb_DNA-binding PF00249.31 ELR12649.1 - 1.4e-08 34.8 3.4 0.0033 17.6 0.2 3.0 2 0 0 2 2 2 2 Myb-like DNA-binding domain Tudor-knot PF11717.8 ELR12649.1 - 0.00039 20.3 0.2 0.0017 18.2 0.2 2.2 1 0 0 1 1 1 1 RNA binding activity-knot of a chromodomain TFIIF_alpha PF05793.12 ELR12649.1 - 3 6.3 99.2 0.092 11.3 62.0 2.1 2 0 0 2 2 2 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) MORN PF02493.20 ELR12650.1 - 3.5e-46 152.4 60.2 4e-05 23.2 0.2 13.7 14 0 0 14 14 14 12 MORN repeat RhoGEF PF00621.20 ELR12650.1 - 2.6e-41 141.9 1.6 3.9e-41 141.3 1.6 1.3 1 0 0 1 1 1 1 RhoGEF domain PH_13 PF16652.5 ELR12650.1 - 0.012 15.5 0.0 0.024 14.5 0.0 1.4 1 0 0 1 1 1 0 Pleckstrin homology domain PH_16 PF17838.1 ELR12650.1 - 0.043 13.7 0.0 0.073 12.9 0.0 1.3 1 0 0 1 1 1 0 PH domain PH PF00169.29 ELR12650.1 - 0.16 12.5 0.0 0.43 11.1 0.0 1.7 1 0 0 1 1 1 0 PH domain SR-25 PF10500.9 ELR12651.1 - 0.92 9.1 14.1 1.8 8.1 14.1 1.4 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein CCSAP PF15748.5 ELR12651.1 - 1.9 8.6 5.1 3 7.9 5.1 1.3 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated ABM PF03992.16 ELR12652.1 - 3.6e-05 23.8 0.3 5.1e-05 23.3 0.3 1.2 1 0 0 1 1 1 1 Antibiotic biosynthesis monooxygenase DUF4121 PF13497.6 ELR12652.1 - 0.06 12.5 0.3 0.072 12.2 0.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4121) Linker_histone PF00538.19 ELR12653.1 - 3.8e-10 40.0 0.0 8.2e-10 38.9 0.0 1.5 1 0 0 1 1 1 1 linker histone H1 and H5 family Virulence_fact PF13769.6 ELR12653.1 - 0.23 11.7 3.5 0.32 11.3 0.2 3.0 2 0 0 2 2 2 0 Virulence factor TIM21 PF08294.11 ELR12653.1 - 0.47 10.3 5.0 10 6.0 0.1 2.7 2 0 0 2 2 2 0 TIM21 CTP_transf_like PF01467.26 ELR12654.1 - 6.8e-08 32.8 0.0 1.4e-07 31.8 0.0 1.6 1 0 0 1 1 1 1 Cytidylyltransferase-like PLC-beta_C PF08703.10 ELR12655.1 - 0.11 12.4 0.9 0.16 11.9 0.9 1.1 1 0 0 1 1 1 0 PLC-beta C terminal zf-TRAF PF02176.18 ELR12655.1 - 0.17 12.6 0.4 0.36 11.5 0.4 1.5 1 0 0 1 1 1 0 TRAF-type zinc finger TFIIB PF00382.19 ELR12656.1 - 0.012 15.6 0.3 0.71 10.0 0.1 2.6 2 0 0 2 2 2 0 Transcription factor TFIIB repeat OrfB_Zn_ribbon PF07282.11 ELR12656.1 - 0.054 13.4 0.4 0.11 12.4 0.4 1.6 1 0 0 1 1 1 0 Putative transposase DNA-binding domain S-AdoMet_synt_C PF02773.16 ELR12657.1 - 6e-65 217.4 0.0 1.1e-64 216.5 0.0 1.5 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, C-terminal domain S-AdoMet_synt_M PF02772.16 ELR12657.1 - 1.6e-45 154.2 0.0 2.7e-45 153.5 0.0 1.4 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, central domain S-AdoMet_synt_N PF00438.20 ELR12657.1 - 1.4e-42 144.3 0.1 3.1e-42 143.3 0.1 1.6 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, N-terminal domain Complex1_LYR PF05347.15 ELR12658.1 - 5.8e-05 23.0 0.2 0.0026 17.8 0.1 2.3 2 0 0 2 2 2 2 Complex 1 protein (LYR family) ApbA_C PF08546.11 ELR12658.1 - 0.054 13.7 0.1 0.07 13.3 0.1 1.2 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA C terminal PolyA_pol PF01743.20 ELR12659.1 - 2.8e-21 76.2 0.0 4.6e-21 75.6 0.0 1.3 1 0 0 1 1 1 1 Poly A polymerase head domain PolyA_pol_RNAbd PF12627.7 ELR12659.1 - 0.024 14.4 1.7 0.028 14.2 0.2 1.9 2 0 0 2 2 2 0 Probable RNA and SrmB- binding site of polymerase A zf_CCCH_4 PF18345.1 ELR12660.1 - 1.1e-05 25.2 6.6 2e-05 24.5 6.6 1.4 1 0 0 1 1 1 1 Zinc finger domain zf-CCCH PF00642.24 ELR12660.1 - 3e-05 23.8 0.9 6e-05 22.8 0.9 1.5 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Methyltransf_32 PF13679.6 ELR12660.1 - 0.0025 17.8 0.0 0.098 12.6 0.0 2.4 2 0 0 2 2 2 1 Methyltransferase domain zf-CCCH_2 PF14608.6 ELR12660.1 - 0.017 15.6 1.7 0.029 14.8 1.7 1.4 1 0 0 1 1 1 0 RNA-binding, Nab2-type zinc finger zf-CCCH_4 PF18044.1 ELR12660.1 - 0.017 14.9 3.7 0.032 14.0 3.7 1.5 1 0 0 1 1 1 0 CCCH-type zinc finger KH_7 PF17214.3 ELR12660.1 - 0.085 12.8 0.0 0.15 12.0 0.0 1.3 1 0 0 1 1 1 0 KH domain PAS_9 PF13426.7 ELR12661.1 - 2e-34 118.0 0.0 2e-11 44.0 0.0 3.4 3 0 0 3 3 3 3 PAS domain PAS PF00989.25 ELR12661.1 - 7.8e-31 106.4 0.0 6.8e-12 45.4 0.0 3.2 3 0 0 3 3 3 3 PAS fold SAM_1 PF00536.30 ELR12661.1 - 9.6e-17 61.2 0.1 1.7e-16 60.4 0.1 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) PAS_4 PF08448.10 ELR12661.1 - 8.1e-11 42.2 0.0 0.0025 18.1 0.0 3.3 3 0 0 3 3 3 2 PAS fold SAM_2 PF07647.17 ELR12661.1 - 5e-10 39.4 0.0 9.4e-10 38.5 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) PB1 PF00564.24 ELR12661.1 - 3.6e-09 36.4 0.2 9.5e-09 35.1 0.0 1.8 2 0 0 2 2 2 1 PB1 domain PAS_8 PF13188.7 ELR12661.1 - 9.6e-09 35.1 0.0 0.0035 17.3 0.0 3.5 3 0 0 3 3 3 2 PAS domain PAS_3 PF08447.12 ELR12661.1 - 6.5e-05 23.2 0.0 0.58 10.5 0.0 3.5 3 0 0 3 3 3 2 PAS fold SAM_PNT PF02198.16 ELR12661.1 - 0.002 18.0 0.0 0.0043 17.0 0.0 1.5 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain PAS_10 PF13596.6 ELR12661.1 - 0.038 14.6 0.1 17 6.0 0.0 2.8 3 0 0 3 3 3 0 PAS domain ATP-synt_Eps PF04627.13 ELR12662.1 - 3.5e-19 68.5 0.4 4.6e-19 68.1 0.4 1.2 1 0 0 1 1 1 1 Mitochondrial ATP synthase epsilon chain AlcCBM31 PF11606.8 ELR12662.1 - 0.071 13.3 0.0 0.086 13.0 0.0 1.1 1 0 0 1 1 1 0 Family 31 carbohydrate binding protein RRM_1 PF00076.22 ELR12663.1 - 1.8e-10 40.5 2.2 4.3e-10 39.3 0.0 2.5 3 0 0 3 3 3 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) GRP PF07172.11 ELR12663.1 - 0.018 15.7 24.7 0.018 15.7 24.7 4.4 3 2 2 5 5 5 0 Glycine rich protein family XRN1_D2_D3 PF18334.1 ELR12663.1 - 4.4 7.6 6.7 28 5.0 1.1 2.9 3 1 1 4 4 4 0 Exoribonuclease Xrn1 D2/D3 domain SRP-alpha_N PF04086.13 ELR12663.1 - 4.7 7.0 25.6 0.96 9.3 19.3 2.0 2 0 0 2 2 2 0 Signal recognition particle, alpha subunit, N-terminal RhoGEF PF00621.20 ELR12664.1 - 1.9e-46 158.6 2.6 1.9e-46 158.6 2.6 1.9 2 0 0 2 2 2 1 RhoGEF domain IQ_SEC7_PH PF16453.5 ELR12664.1 - 0.00011 22.2 0.1 0.00029 20.8 0.1 1.7 1 0 0 1 1 1 1 PH domain PH PF00169.29 ELR12664.1 - 0.0012 19.3 0.0 0.0034 17.9 0.0 1.8 1 0 0 1 1 1 1 PH domain PH_4 PF15404.6 ELR12664.1 - 0.038 13.8 0.1 0.038 13.8 0.1 3.2 1 1 2 3 3 3 0 Pleckstrin homology domain RIH_assoc PF08454.11 ELR12664.1 - 0.28 11.1 1.7 0.45 10.4 0.6 2.0 2 0 0 2 2 2 0 RyR and IP3R Homology associated LysM PF01476.20 ELR12665.1 - 0.047 13.8 0.0 0.092 12.8 0.0 1.5 1 0 0 1 1 1 0 LysM domain MORN PF02493.20 ELR12666.1 - 3.2e-27 92.8 39.2 2.7e-07 30.1 0.7 9.8 9 1 0 9 9 9 7 MORN repeat DUF3048_C PF17479.2 ELR12666.1 - 0.0043 17.4 2.6 2.7 8.4 0.0 2.9 2 1 1 3 3 3 2 Protein of unknown function (DUF3048) C-terminal domain DNA_alkylation PF08713.11 ELR12667.1 - 4.4e-60 203.0 6.7 5e-60 202.8 6.7 1.0 1 0 0 1 1 1 1 DNA alkylation repair enzyme Alliinase_C PF04864.13 ELR12667.1 - 0.0033 16.4 0.0 0.005 15.8 0.0 1.2 1 0 0 1 1 1 1 Allinase SET PF00856.28 ELR12668.1 - 8.2e-05 23.1 0.1 0.00079 19.9 0.1 2.3 1 1 0 1 1 1 1 SET domain zf-HC5HC2H PF13771.6 ELR12668.1 - 0.00075 19.7 5.6 0.00075 19.7 5.6 2.0 2 0 0 2 2 2 1 PHD-like zinc-binding domain RFX5_DNA_bdg PF14621.6 ELR12668.1 - 0.0087 15.9 1.0 0.023 14.5 1.0 1.6 1 0 0 1 1 1 1 RFX5 DNA-binding domain zf-HC5HC2H_2 PF13832.6 ELR12668.1 - 0.11 12.7 4.6 0.19 11.9 3.5 2.0 2 0 0 2 2 2 0 PHD-zinc-finger like domain RibD_C PF01872.17 ELR12669.1 - 4.3e-19 69.1 0.0 7.3e-19 68.4 0.0 1.4 1 1 0 1 1 1 1 RibD C-terminal domain DHFR_1 PF00186.19 ELR12669.1 - 0.0016 18.2 0.0 0.0022 17.7 0.0 1.2 1 0 0 1 1 1 1 Dihydrofolate reductase F-box-like PF12937.7 ELR12670.1 - 0.0025 17.7 0.6 0.005 16.7 0.6 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ELR12670.1 - 0.024 14.5 0.1 0.053 13.4 0.1 1.5 1 0 0 1 1 1 0 F-box domain Peptidase_M13_N PF05649.13 ELR12672.1 - 7.3e-90 302.4 0.0 9.1e-90 302.1 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M13 Peptidase_M13 PF01431.21 ELR12672.1 - 1.7e-66 223.8 0.0 2.9e-66 223.0 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M13 Ras PF00071.22 ELR12673.1 - 8.1e-49 165.3 0.1 1.1e-48 164.9 0.1 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR12673.1 - 1.3e-27 96.4 0.1 2.5e-27 95.5 0.1 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR12673.1 - 8.5e-14 51.4 0.0 1.1e-13 51.0 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 ELR12673.1 - 0.0055 16.2 0.0 0.0084 15.6 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Ras PF00071.22 ELR12674.1 - 1e-34 119.5 0.0 1.4e-34 119.0 0.0 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR12674.1 - 9.6e-24 83.9 0.0 1.6e-23 83.2 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ank_5 PF13857.6 ELR12674.1 - 1.9e-15 56.7 0.2 4.9e-05 23.5 0.0 3.7 4 0 0 4 4 3 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 ELR12674.1 - 5e-15 55.8 0.0 3.3e-06 27.6 0.0 3.5 2 1 0 3 3 3 3 Ankyrin repeats (3 copies) Ank_3 PF13606.6 ELR12674.1 - 4.5e-13 48.1 0.2 0.0012 19.1 0.0 4.0 3 0 0 3 3 3 2 Ankyrin repeat F-box-like PF12937.7 ELR12674.1 - 2.5e-10 40.1 0.1 5.4e-10 39.0 0.1 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ELR12674.1 - 2e-09 37.1 0.1 3.6e-09 36.3 0.1 1.4 1 0 0 1 1 1 1 F-box domain Ank_4 PF13637.6 ELR12674.1 - 1.6e-08 34.9 0.1 0.0057 17.2 0.0 3.4 3 0 0 3 3 3 2 Ankyrin repeats (many copies) MMR_HSR1 PF01926.23 ELR12674.1 - 2.2e-06 27.7 0.0 3.8e-06 26.9 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase Ank PF00023.30 ELR12674.1 - 3.6e-06 27.2 0.7 0.3 11.6 0.0 3.6 3 0 0 3 3 3 2 Ankyrin repeat F-box_4 PF15966.5 ELR12674.1 - 1e-05 25.3 0.1 3e-05 23.9 0.0 1.8 2 0 0 2 2 2 1 F-box Arf PF00025.21 ELR12674.1 - 0.0013 18.2 0.0 0.002 17.6 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family AAA_16 PF13191.6 ELR12674.1 - 0.065 13.6 0.0 0.36 11.2 0.0 2.0 1 1 0 2 2 2 0 AAA ATPase domain AAA_22 PF13401.6 ELR12674.1 - 0.09 13.1 0.0 0.34 11.2 0.0 2.1 2 1 0 2 2 2 0 AAA domain MCM PF00493.23 ELR12674.1 - 0.09 11.9 0.0 0.19 10.8 0.0 1.5 1 0 0 1 1 1 0 MCM P-loop domain AAA_33 PF13671.6 ELR12674.1 - 0.18 12.0 0.5 0.92 9.7 0.0 2.6 3 1 0 3 3 3 0 AAA domain Choline_transpo PF04515.12 ELR12675.1 - 2.9e-32 112.2 12.4 6.7e-32 111.0 12.4 1.8 1 1 0 1 1 1 1 Plasma-membrane choline transporter Ras PF00071.22 ELR12676.1 - 2.6e-55 186.4 0.1 3e-55 186.2 0.1 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR12676.1 - 1.5e-34 118.7 0.0 2.1e-34 118.3 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR12676.1 - 2.7e-15 56.3 0.0 3.3e-15 56.0 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 ELR12676.1 - 8.4e-05 22.0 0.0 0.00011 21.6 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 ELR12676.1 - 0.0001 22.3 0.3 0.3 11.0 0.0 2.3 2 0 0 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 ELR12676.1 - 0.00016 21.8 0.0 0.00022 21.3 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase PduV-EutP PF10662.9 ELR12676.1 - 0.0064 16.2 0.1 0.41 10.4 0.0 2.1 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation ATP_bind_1 PF03029.17 ELR12676.1 - 0.015 15.1 0.0 0.07 12.9 0.0 1.8 1 1 1 2 2 2 0 Conserved hypothetical ATP binding protein YwhD PF08741.10 ELR12676.1 - 0.018 14.7 0.0 0.025 14.3 0.0 1.2 1 0 0 1 1 1 0 YwhD family AAA_22 PF13401.6 ELR12676.1 - 0.023 15.0 0.0 0.15 12.4 0.0 2.2 1 1 0 1 1 1 0 AAA domain ResIII PF04851.15 ELR12676.1 - 0.025 14.6 0.0 0.18 11.8 0.0 1.8 1 1 1 2 2 2 0 Type III restriction enzyme, res subunit AAA_24 PF13479.6 ELR12676.1 - 0.026 14.2 0.1 0.061 13.0 0.0 1.6 2 0 0 2 2 2 0 AAA domain NACHT PF05729.12 ELR12676.1 - 0.034 14.1 0.0 0.053 13.4 0.0 1.3 1 0 0 1 1 1 0 NACHT domain AAA_5 PF07728.14 ELR12676.1 - 0.036 14.1 0.0 0.07 13.1 0.0 1.6 2 1 0 2 2 2 0 AAA domain (dynein-related subfamily) IstB_IS21 PF01695.17 ELR12676.1 - 0.038 13.7 0.0 0.078 12.7 0.0 1.6 2 0 0 2 2 2 0 IstB-like ATP binding protein SRPRB PF09439.10 ELR12676.1 - 0.042 13.3 0.0 0.084 12.3 0.0 1.7 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit Sigma54_activat PF00158.26 ELR12676.1 - 0.06 13.0 0.0 0.11 12.1 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_16 PF13191.6 ELR12676.1 - 0.1 12.9 0.1 0.12 12.7 0.1 1.4 1 1 0 1 1 1 0 AAA ATPase domain TsaE PF02367.17 ELR12676.1 - 0.13 12.2 0.1 0.39 10.7 0.0 1.7 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE EF-hand_1 PF00036.32 ELR12677.1 - 6.6e-39 128.6 10.1 3.5e-09 35.5 0.4 4.1 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 ELR12677.1 - 5e-33 113.4 3.3 4e-17 62.4 0.8 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 ELR12677.1 - 7.1e-30 100.4 5.6 1.1e-08 34.3 0.0 4.5 4 1 1 5 5 5 4 EF-hand domain EF-hand_5 PF13202.6 ELR12677.1 - 2.3e-28 96.4 9.5 5.3e-08 32.0 0.0 4.4 4 0 0 4 4 4 4 EF hand EF-hand_8 PF13833.6 ELR12677.1 - 2.7e-28 97.6 11.4 6.4e-15 54.7 0.3 4.0 1 1 3 4 4 4 4 EF-hand domain pair EF-hand_9 PF14658.6 ELR12677.1 - 1.3e-15 57.4 0.0 3.6e-09 36.8 0.0 2.1 2 0 0 2 2 2 2 EF-hand domain SPARC_Ca_bdg PF10591.9 ELR12677.1 - 1.9e-10 41.0 0.0 0.00024 21.4 0.0 2.1 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 ELR12677.1 - 2.5e-10 40.3 0.8 0.00013 21.9 0.1 2.1 1 1 1 2 2 2 2 Cytoskeletal-regulatory complex EF hand Dockerin_1 PF00404.18 ELR12677.1 - 1.1e-05 25.5 1.4 0.071 13.3 0.0 2.9 1 1 2 3 3 3 2 Dockerin type I domain TerB PF05099.13 ELR12677.1 - 8.3e-05 22.6 0.1 0.033 14.1 0.1 2.2 1 1 1 2 2 2 2 Tellurite resistance protein TerB Caleosin PF05042.13 ELR12677.1 - 9.9e-05 22.3 0.3 1.6 8.6 0.0 3.5 1 1 3 4 4 4 2 Caleosin related protein UPF0154 PF03672.13 ELR12677.1 - 0.00019 21.4 0.0 0.065 13.3 0.0 2.9 3 0 0 3 3 3 1 Uncharacterised protein family (UPF0154) DUF3349 PF11829.8 ELR12677.1 - 0.0031 18.3 0.2 2.4 9.0 0.0 2.7 1 1 2 3 3 3 1 Protein of unknown function (DUF3349) Spore_III_AB PF09548.10 ELR12677.1 - 0.02 15.0 0.2 0.044 13.9 0.2 1.6 1 1 0 1 1 1 0 Stage III sporulation protein AB (spore_III_AB) SurA_N_2 PF13623.6 ELR12677.1 - 0.027 14.4 0.9 0.34 10.8 0.4 2.1 1 1 1 2 2 2 0 SurA N-terminal domain ARL2_Bind_BART PF11527.8 ELR12677.1 - 0.035 14.2 1.1 6.8 6.8 0.4 2.6 2 1 0 2 2 2 0 The ARF-like 2 binding protein BART Nucleo_P87 PF07267.11 ELR12677.1 - 0.042 12.7 0.2 0.044 12.7 0.2 1.0 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 EF-hand_11 PF08976.11 ELR12677.1 - 0.14 13.0 0.0 0.58 11.1 0.0 1.8 1 1 1 2 2 2 0 EF-hand domain ubiquitin PF00240.23 ELR12678.1 - 9.7e-10 38.1 0.0 1.6e-09 37.4 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin family Ubiquitin_2 PF14560.6 ELR12678.1 - 0.086 13.3 0.0 0.33 11.5 0.0 2.0 1 1 1 2 2 2 0 Ubiquitin-like domain zf-C2H2_2 PF12756.7 ELR12679.1 - 1.1e-45 154.1 15.7 2.4e-24 85.6 6.5 3.3 3 0 0 3 3 3 3 C2H2 type zinc-finger (2 copies) zf-C2H2_4 PF13894.6 ELR12679.1 - 7.7e-09 35.7 23.3 0.023 15.5 1.3 5.5 5 0 0 5 5 5 3 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 ELR12679.1 - 2.4e-05 24.5 7.6 2.4e-05 24.5 7.6 3.9 5 0 0 5 5 4 1 Zinc-finger double-stranded RNA-binding PyrI_C PF02748.15 ELR12679.1 - 0.0033 17.3 1.4 0.096 12.6 0.1 3.2 3 0 0 3 3 3 1 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-C2H2 PF00096.26 ELR12679.1 - 0.0081 16.6 29.9 0.071 13.6 3.2 5.2 5 0 0 5 5 5 2 Zinc finger, C2H2 type zf-BED PF02892.15 ELR12679.1 - 0.017 15.1 10.8 0.018 15.0 1.5 4.1 4 0 0 4 4 4 0 BED zinc finger Clr5 PF14420.6 ELR12679.1 - 0.059 13.6 3.4 9.8 6.5 0.0 4.1 4 0 0 4 4 4 0 Clr5 domain zf-met PF12874.7 ELR12679.1 - 0.58 10.6 18.8 0.15 12.5 5.4 4.4 5 0 0 5 5 5 0 Zinc-finger of C2H2 type zf-H2C2_2 PF13465.6 ELR12679.1 - 0.84 10.2 0.0 0.84 10.2 0.0 4.8 5 0 0 5 5 4 0 Zinc-finger double domain zf-C2H2_3rep PF18868.1 ELR12679.1 - 2.2 9.0 11.5 30 5.3 2.6 4.7 3 2 2 5 5 5 0 Zinc finger C2H2-type, 3 repeats zf-Di19 PF05605.12 ELR12679.1 - 4.7 7.6 18.7 3 8.2 0.4 5.0 5 0 0 5 5 5 0 Drought induced 19 protein (Di19), zinc-binding Acylphosphatase PF00708.18 ELR12680.1 - 1.4e-24 86.3 2.2 3.4e-24 85.0 0.0 2.0 2 0 0 2 2 2 1 Acylphosphatase RR_TM4-6 PF06459.12 ELR12680.1 - 0.28 11.0 10.1 0.25 11.1 10.1 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Nucleo_P87 PF07267.11 ELR12680.1 - 0.81 8.5 9.1 0.92 8.3 9.1 1.0 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 Presenilin PF01080.17 ELR12680.1 - 3.4 6.3 8.8 4.1 6.1 8.8 1.1 1 0 0 1 1 1 0 Presenilin RNA_polI_A34 PF08208.11 ELR12680.1 - 5.6 7.0 29.2 7.9 6.5 29.2 1.2 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 Coilin_N PF15862.5 ELR12680.1 - 6.6 6.5 18.3 9.3 6.0 18.3 1.4 1 0 0 1 1 1 0 Coilin N-terminus NIPSNAP PF07978.13 ELR12681.1 - 3.5e-47 158.8 1.8 4.4e-28 97.5 0.2 2.4 2 0 0 2 2 2 2 NIPSNAP BRCT_3 PF18428.1 ELR12683.1 - 0.039 14.0 0.0 0.07 13.2 0.0 1.4 1 0 0 1 1 1 0 BRCA1 C Terminus (BRCT) domain Peptidase_M13 PF01431.21 ELR12684.1 - 1.5e-65 220.7 0.0 2.7e-65 219.8 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M13 Peptidase_M13_N PF05649.13 ELR12684.1 - 6.4e-50 170.9 0.0 2.3e-49 169.1 0.0 1.7 1 1 0 1 1 1 1 Peptidase family M13 Peptidase_M13_N PF05649.13 ELR12685.1 - 5.9e-19 69.0 0.0 7e-19 68.8 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M13 TPR_12 PF13424.6 ELR12686.1 - 0.012 15.9 0.9 2.5 8.4 0.2 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat RFX_DNA_binding PF02257.15 ELR12687.1 - 9.8e-12 45.3 0.0 1.6e-11 44.6 0.0 1.3 1 0 0 1 1 1 1 RFX DNA-binding domain Pox_D5 PF03288.16 ELR12687.1 - 0.0012 19.3 0.0 0.0017 18.8 0.0 1.2 1 0 0 1 1 1 1 Poxvirus D5 protein-like Longin PF13774.6 ELR12688.1 - 1.2e-19 70.1 0.5 1.2e-19 70.1 0.5 1.6 2 0 0 2 2 2 1 Regulated-SNARE-like domain Synaptobrevin PF00957.21 ELR12688.1 - 4.2e-18 64.9 0.0 7.2e-18 64.2 0.0 1.4 1 0 0 1 1 1 1 Synaptobrevin Ras PF00071.22 ELR12689.1 - 3.3e-50 169.9 0.0 3.8e-50 169.6 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR12689.1 - 2.7e-18 66.3 0.0 3.5e-18 66.0 0.0 1.1 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR12689.1 - 1.1e-08 34.8 0.0 1.3e-08 34.5 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 ELR12689.1 - 2.5e-05 24.3 0.0 0.15 12.0 0.0 2.1 2 0 0 2 2 2 2 RsgA GTPase GTP_EFTU PF00009.27 ELR12689.1 - 5.1e-05 22.9 0.0 0.00024 20.7 0.0 1.9 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain FeoB_N PF02421.18 ELR12689.1 - 0.00083 18.9 0.0 0.0029 17.2 0.0 1.8 1 1 0 1 1 1 1 Ferrous iron transport protein B MMR_HSR1 PF01926.23 ELR12689.1 - 0.0014 18.7 0.0 0.002 18.2 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase ParA PF10609.9 ELR12689.1 - 0.01 15.3 0.0 0.085 12.3 0.0 2.0 2 0 0 2 2 2 0 NUBPL iron-transfer P-loop NTPase AAA_25 PF13481.6 ELR12689.1 - 0.012 15.3 0.0 0.02 14.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain NB-ARC PF00931.22 ELR12689.1 - 0.025 13.8 0.0 0.031 13.5 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain Septin PF00735.18 ELR12689.1 - 0.085 12.1 0.0 0.13 11.5 0.0 1.2 1 0 0 1 1 1 0 Septin G-alpha PF00503.20 ELR12689.1 - 0.12 11.5 0.0 7.6 5.6 0.0 2.1 1 1 0 2 2 2 0 G-protein alpha subunit AAA_24 PF13479.6 ELR12689.1 - 0.12 12.1 0.0 0.13 11.9 0.0 1.2 1 0 0 1 1 1 0 AAA domain UVR PF02151.19 ELR12689.1 - 0.2 11.4 0.4 0.52 10.1 0.4 1.7 1 0 0 1 1 1 0 UvrB/uvrC motif Metallophos PF00149.28 ELR12690.1 - 0.00029 21.4 0.2 0.002 18.6 0.0 2.3 2 1 0 2 2 2 1 Calcineurin-like phosphoesterase Fucose_iso_C PF02952.17 ELR12692.1 - 0.25 11.1 2.3 9.3 6.0 0.2 2.1 2 0 0 2 2 2 0 L-fucose isomerase, C-terminal domain NUDIX PF00293.28 ELR12693.1 - 1e-06 28.8 0.2 1.9e-06 27.9 0.2 1.4 1 0 0 1 1 1 1 NUDIX domain Pyr_redox_2 PF07992.14 ELR12694.1 - 7.1e-37 127.2 0.1 1.3e-36 126.4 0.0 1.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 ELR12694.1 - 1.2e-15 57.8 0.5 6.1e-09 36.3 0.0 3.2 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 ELR12694.1 - 6.1e-09 35.9 1.9 0.057 13.0 0.0 3.5 3 1 1 4 4 4 3 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 ELR12694.1 - 2.3e-07 30.4 0.0 1.8e-05 24.2 0.0 2.1 1 1 1 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 ELR12694.1 - 1.5e-05 25.1 2.0 0.03 14.5 0.0 2.8 3 0 0 3 3 2 2 NAD(P)-binding Rossmann-like domain Lycopene_cycl PF05834.12 ELR12694.1 - 1.5e-05 24.3 0.4 0.03 13.4 0.2 2.6 3 0 0 3 3 3 2 Lycopene cyclase protein K_oxygenase PF13434.6 ELR12694.1 - 2.1e-05 23.8 0.1 0.13 11.4 0.0 2.2 1 1 0 2 2 2 2 L-lysine 6-monooxygenase (NADPH-requiring) Trp_halogenase PF04820.14 ELR12694.1 - 4.4e-05 22.5 0.0 0.083 11.7 0.0 2.2 2 0 0 2 2 2 2 Tryptophan halogenase DUF1188 PF06690.11 ELR12694.1 - 0.00014 21.5 0.0 0.008 15.8 0.0 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF1188) Sacchrp_dh_NADP PF03435.18 ELR12694.1 - 0.002 18.4 5.6 1.1 9.5 0.3 3.3 3 0 0 3 3 3 2 Saccharopine dehydrogenase NADP binding domain NAD_binding_9 PF13454.6 ELR12694.1 - 0.0031 17.5 3.7 1.4 8.9 0.1 4.1 2 2 2 4 4 4 1 FAD-NAD(P)-binding NAD_binding_7 PF13241.6 ELR12694.1 - 0.0053 17.2 0.7 0.72 10.3 0.0 2.6 3 0 0 3 3 3 1 Putative NAD(P)-binding FAD_binding_3 PF01494.19 ELR12694.1 - 0.0056 16.0 0.1 0.49 9.6 0.0 2.4 2 0 0 2 2 2 1 FAD binding domain AlaDh_PNT_C PF01262.21 ELR12694.1 - 0.0062 15.9 0.1 0.8 9.0 0.0 2.5 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain TrkA_N PF02254.18 ELR12694.1 - 0.0076 16.5 1.6 3.9 7.7 0.0 3.0 3 0 0 3 3 3 2 TrkA-N domain FAD_binding_2 PF00890.24 ELR12694.1 - 0.009 15.1 0.1 0.97 8.4 0.0 2.5 3 0 0 3 3 3 1 FAD binding domain HI0933_like PF03486.14 ELR12694.1 - 0.04 12.6 1.1 0.98 8.0 0.0 3.1 3 1 0 3 3 3 0 HI0933-like protein GIDA PF01134.22 ELR12694.1 - 0.073 12.1 0.3 18 4.3 0.0 3.0 3 0 0 3 3 3 0 Glucose inhibited division protein A Pkinase_Tyr PF07714.17 ELR12695.1 - 7.1e-61 205.7 0.0 1.1e-60 205.1 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ELR12695.1 - 2.6e-49 168.0 0.0 6.3e-49 166.7 0.0 1.6 2 0 0 2 2 2 1 Protein kinase domain PBP_like_2 PF12849.7 ELR12695.1 - 2.1e-33 116.2 15.0 5.6e-17 62.3 1.0 2.3 2 0 0 2 2 2 2 PBP superfamily domain FTA2 PF13095.6 ELR12695.1 - 0.054 13.1 0.0 5.5 6.5 0.0 2.2 1 1 1 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 EGF_2 PF07974.13 ELR12695.1 - 0.068 13.5 15.2 0.12 12.7 15.2 1.4 1 0 0 1 1 1 0 EGF-like domain TMEM154 PF15102.6 ELR12695.1 - 0.072 13.0 0.0 0.072 13.0 0.0 2.1 2 0 0 2 2 2 0 TMEM154 protein family Guanylate_cyc PF00211.20 ELR12695.1 - 0.083 12.5 0.0 0.2 11.2 0.0 1.6 1 0 0 1 1 1 0 Adenylate and Guanylate cyclase catalytic domain Cadherin_C_2 PF16492.5 ELR12695.1 - 0.1 13.4 0.1 11 6.9 0.0 3.1 3 0 0 3 3 3 0 Cadherin cytoplasmic C-terminal MAGE_N PF12440.8 ELR12695.1 - 3.6 8.3 7.3 8.4 7.1 7.3 1.5 1 0 0 1 1 1 0 Melanoma associated antigen family N terminal Pkinase_Tyr PF07714.17 ELR12696.1 - 6.6e-62 209.1 0.0 8.8e-62 208.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ELR12696.1 - 6.8e-58 196.1 0.0 9.1e-58 195.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.23 ELR12696.1 - 1.6e-06 28.2 0.1 7.1e-06 26.1 0.0 1.9 2 1 1 3 3 3 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 ELR12696.1 - 0.005 15.8 0.0 0.0082 15.1 0.0 1.2 1 0 0 1 1 1 1 Haspin like kinase domain Guanylate_cyc PF00211.20 ELR12696.1 - 0.0073 15.9 0.0 0.012 15.3 0.0 1.3 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain Kinase-like PF14531.6 ELR12696.1 - 0.13 11.5 0.0 0.31 10.3 0.0 1.6 2 0 0 2 2 2 0 Kinase-like Ank_4 PF13637.6 ELR12697.1 - 1.6e-15 57.2 2.4 2.1e-06 28.2 0.2 5.2 5 1 0 5 5 5 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 ELR12697.1 - 1.3e-14 54.5 0.0 4.9e-08 33.4 0.0 4.4 3 1 2 5 5 5 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 ELR12697.1 - 6.6e-12 44.5 0.3 0.027 15.0 0.0 5.8 6 0 0 6 6 6 3 Ankyrin repeat Ank PF00023.30 ELR12697.1 - 2.2e-10 40.5 6.5 0.019 15.4 0.1 5.5 6 0 0 6 6 6 3 Ankyrin repeat F-box-like PF12937.7 ELR12697.1 - 2.1e-09 37.2 0.5 4.7e-09 36.0 0.5 1.6 1 0 0 1 1 1 1 F-box-like Ank_5 PF13857.6 ELR12697.1 - 4.3e-08 33.3 3.2 0.027 14.8 0.6 5.1 3 1 2 5 5 5 3 Ankyrin repeats (many copies) F-box PF00646.33 ELR12697.1 - 0.00014 21.7 0.0 0.00027 20.7 0.0 1.5 1 0 0 1 1 1 1 F-box domain Hydrolase_4 PF12146.8 ELR12698.1 - 2.8e-12 46.4 0.0 6.4e-12 45.3 0.0 1.6 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 ELR12698.1 - 3e-08 33.6 0.0 0.00012 21.8 0.1 2.2 1 1 0 2 2 2 2 alpha/beta hydrolase fold Zeta_toxin PF06414.12 ELR12698.1 - 0.01 15.1 0.0 0.016 14.5 0.0 1.2 1 0 0 1 1 1 0 Zeta toxin Cutinase PF01083.22 ELR12698.1 - 0.16 11.9 0.0 0.25 11.3 0.0 1.2 1 0 0 1 1 1 0 Cutinase RhoGEF PF00621.20 ELR12699.1 - 4.9e-19 69.3 1.5 1.2e-18 68.0 1.5 1.7 1 0 0 1 1 1 1 RhoGEF domain IQ_SEC7_PH PF16453.5 ELR12699.1 - 4.5e-05 23.4 0.1 0.00011 22.2 0.1 1.7 1 0 0 1 1 1 1 PH domain PH_13 PF16652.5 ELR12699.1 - 0.0039 17.0 2.3 0.0089 15.9 0.2 2.6 2 1 1 3 3 3 1 Pleckstrin homology domain zf-RanBP PF00641.18 ELR12700.1 - 1.4e-28 97.8 45.0 7.9e-08 31.5 3.4 5.1 5 0 0 5 5 5 5 Zn-finger in Ran binding protein and others DZR PF12773.7 ELR12700.1 - 1.1e-05 25.3 35.7 0.044 13.8 9.8 3.8 3 2 0 3 3 3 3 Double zinc ribbon zinc-ribbons_6 PF07191.12 ELR12700.1 - 0.00097 19.1 29.7 0.048 13.7 3.7 4.7 3 2 1 4 4 4 3 zinc-ribbons TackOD1 PF18551.1 ELR12700.1 - 0.0026 17.5 30.6 1 9.0 1.0 5.1 5 0 0 5 5 5 5 Thaumarchaeal output domain 1 zf-4CXXC_R1 PF10497.9 ELR12700.1 - 0.036 14.3 33.0 0.2 11.9 1.8 4.9 3 2 2 5 5 5 0 Zinc-finger domain of monoamine-oxidase A repressor R1 PHD PF00628.29 ELR12700.1 - 2.2 8.3 38.9 0.64 10.0 1.9 7.2 8 1 0 8 8 8 0 PHD-finger zinc_ribbon_10 PF10058.9 ELR12700.1 - 5.4 6.8 35.1 3.2 7.6 0.0 7.7 9 1 0 9 9 9 0 Predicted integral membrane zinc-ribbon metal-binding protein 7tm_2 PF00002.24 ELR12701.1 - 1.3e-12 47.5 11.9 2.3e-12 46.8 11.9 1.4 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) Dicty_CAR PF05462.11 ELR12701.1 - 9.2e-10 38.1 11.1 1.3e-09 37.6 11.1 1.2 1 0 0 1 1 1 1 Slime mold cyclic AMP receptor Frizzled PF01534.17 ELR12701.1 - 0.00022 20.4 10.2 0.0016 17.6 5.1 2.1 1 1 1 2 2 2 2 Frizzled/Smoothened family membrane region DUF1211 PF06736.11 ELR12701.1 - 0.049 14.1 1.0 0.21 12.0 0.4 2.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1211) Ank_4 PF13637.6 ELR12702.1 - 2.6e-18 66.1 4.1 1.1e-06 29.0 0.1 6.1 4 1 1 5 5 5 4 Ankyrin repeats (many copies) Ank_2 PF12796.7 ELR12702.1 - 1.9e-16 60.4 0.9 2.9e-07 31.0 0.1 5.3 3 2 2 5 5 5 3 Ankyrin repeats (3 copies) Ank_3 PF13606.6 ELR12702.1 - 1.3e-15 55.9 3.0 0.0037 17.6 0.1 7.3 8 0 0 8 8 8 3 Ankyrin repeat Ank PF00023.30 ELR12702.1 - 1.8e-11 43.9 11.1 0.015 15.7 0.2 6.6 7 0 0 7 7 7 4 Ankyrin repeat Ank_5 PF13857.6 ELR12702.1 - 2.8e-11 43.4 7.8 0.0059 16.9 0.4 7.0 4 1 3 7 7 7 3 Ankyrin repeats (many copies) F-box-like PF12937.7 ELR12702.1 - 1.9e-10 40.5 1.1 5.9e-10 38.9 1.1 1.9 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ELR12702.1 - 0.01 15.7 0.6 0.028 14.3 0.6 1.7 1 0 0 1 1 1 0 F-box domain Pkinase_Tyr PF07714.17 ELR12703.1 - 8.4e-124 412.0 0.0 1.2e-60 205.0 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 ELR12703.1 - 1.1e-107 359.4 0.0 1.2e-56 192.0 0.0 2.3 2 0 0 2 2 2 2 Protein kinase domain PBP_like_2 PF12849.7 ELR12703.1 - 8.5e-33 114.2 8.0 2.5e-17 63.5 1.2 2.3 2 0 0 2 2 2 2 PBP superfamily domain Guanylate_cyc PF00211.20 ELR12703.1 - 5.4e-11 42.4 0.0 1.4e-10 41.1 0.0 1.6 1 1 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain APH PF01636.23 ELR12703.1 - 2.9e-08 33.9 0.1 3.2e-05 24.0 0.0 3.0 3 0 0 3 3 3 2 Phosphotransferase enzyme family Haspin_kinase PF12330.8 ELR12703.1 - 0.00042 19.4 0.0 0.041 12.8 0.0 2.5 3 0 0 3 3 3 1 Haspin like kinase domain Kinase-like PF14531.6 ELR12703.1 - 0.00085 18.7 0.1 1.1 8.5 0.1 2.3 2 0 0 2 2 2 2 Kinase-like FTA2 PF13095.6 ELR12703.1 - 0.0027 17.4 0.0 0.61 9.7 0.0 3.2 2 1 1 3 3 3 1 Kinetochore Sim4 complex subunit FTA2 RIO1 PF01163.22 ELR12703.1 - 0.0063 16.1 0.8 1.3 8.6 0.1 2.3 2 0 0 2 2 2 2 RIO1 family EGF_2 PF07974.13 ELR12703.1 - 0.016 15.6 14.8 0.03 14.7 14.8 1.5 1 0 0 1 1 1 0 EGF-like domain Kdo PF06293.14 ELR12703.1 - 0.021 14.2 0.3 5.4 6.3 0.0 2.4 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 ELR12703.1 - 0.069 11.9 0.0 3.1 6.5 0.0 2.2 2 0 0 2 2 2 0 Fungal protein kinase TMEM154 PF15102.6 ELR12703.1 - 0.13 12.1 0.0 0.28 11.1 0.0 1.4 1 0 0 1 1 1 0 TMEM154 protein family PseudoU_synth_2 PF00849.22 ELR12704.1 - 1.1e-11 45.1 0.9 5.2e-08 33.1 0.1 2.3 1 1 1 2 2 2 2 RNA pseudouridylate synthase Arrestin_N PF00339.29 ELR12705.1 - 3.2e-06 27.2 0.0 8e-06 26.0 0.0 1.6 1 0 0 1 1 1 1 Arrestin (or S-antigen), N-terminal domain Arrestin_C PF02752.22 ELR12705.1 - 0.00037 21.0 0.0 0.064 13.7 0.0 3.2 3 0 0 3 3 3 1 Arrestin (or S-antigen), C-terminal domain F-box-like PF12937.7 ELR12705.1 - 0.00066 19.5 0.0 0.0014 18.5 0.0 1.5 1 0 0 1 1 1 1 F-box-like DUF2457 PF10446.9 ELR12705.1 - 0.032 13.4 13.8 0.058 12.5 13.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Nop14 PF04147.12 ELR12705.1 - 0.16 10.2 6.6 0.25 9.5 6.6 1.3 1 0 0 1 1 1 0 Nop14-like family AP_endonuc_2 PF01261.24 ELR12706.1 - 5.4e-29 101.1 0.6 8.8e-29 100.5 0.6 1.3 1 0 0 1 1 1 1 Xylose isomerase-like TIM barrel AP_endonuc_2_N PF07582.12 ELR12706.1 - 1.7e-22 78.9 0.1 3.6e-22 77.8 0.1 1.6 1 0 0 1 1 1 1 AP endonuclease family 2 C terminus Peptidase_S10 PF00450.22 ELR12707.1 - 1.8e-119 399.9 0.8 2e-119 399.7 0.8 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase Peptidase_S9 PF00326.21 ELR12707.1 - 0.042 13.3 0.0 4.1 6.8 0.0 2.3 2 0 0 2 2 2 0 Prolyl oligopeptidase family ChW PF07538.11 ELR12707.1 - 0.12 12.3 0.3 0.28 11.2 0.3 1.6 1 0 0 1 1 1 0 Clostridial hydrophobic W UFC1 PF08694.11 ELR12708.1 - 2.7e-81 270.7 0.3 3.1e-81 270.5 0.3 1.0 1 0 0 1 1 1 1 Ubiquitin-fold modifier-conjugating enzyme 1 UQ_con PF00179.26 ELR12708.1 - 0.00049 19.8 0.3 0.0012 18.5 0.3 1.6 1 1 0 1 1 1 1 Ubiquitin-conjugating enzyme NAGLU_N PF12971.7 ELR12708.1 - 0.016 15.0 0.0 0.023 14.5 0.0 1.3 1 0 0 1 1 1 0 Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain RFX_DNA_binding PF02257.15 ELR12710.1 - 1e-10 42.1 0.1 2.1e-10 41.1 0.1 1.5 1 0 0 1 1 1 1 RFX DNA-binding domain CDC45 PF02724.14 ELR12710.1 - 0.27 9.5 2.1 0.38 9.0 2.1 1.1 1 0 0 1 1 1 0 CDC45-like protein Abhydrolase_1 PF00561.20 ELR12712.1 - 6.7e-12 45.6 0.0 1.6e-07 31.3 0.0 2.2 2 0 0 2 2 2 2 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 ELR12712.1 - 8.7e-08 31.7 0.0 1.8e-05 24.2 0.0 2.2 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 ELR12712.1 - 6.9e-06 26.8 1.5 7.3e-06 26.7 0.4 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.21 ELR12712.1 - 0.00027 20.5 0.0 0.25 10.8 0.0 2.6 2 1 1 3 3 3 2 Prolyl oligopeptidase family Peptidase_S15 PF02129.18 ELR12712.1 - 0.0015 18.2 0.0 0.022 14.3 0.0 2.2 1 1 1 2 2 2 1 X-Pro dipeptidyl-peptidase (S15 family) Abhydrolase_4 PF08386.10 ELR12712.1 - 0.044 13.9 0.0 0.15 12.2 0.0 1.8 2 0 0 2 2 2 0 TAP-like protein Gb3_synth PF04572.12 ELR12713.1 - 0.016 15.4 0.1 0.018 15.2 0.1 1.0 1 0 0 1 1 1 0 Alpha 1,4-glycosyltransferase conserved region LapA_dom PF06305.11 ELR12715.1 - 0.063 13.1 0.9 0.19 11.5 0.9 1.9 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain DUF4395 PF14340.6 ELR12715.1 - 0.14 12.4 2.9 0.39 11.0 0.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4395) Phage_holin_3_6 PF07332.11 ELR12715.1 - 0.69 10.0 5.7 0.28 11.2 0.8 2.2 2 0 0 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III Telomerase_RBD PF12009.8 ELR12717.1 - 1.2e-35 122.5 1.5 3.9e-35 120.9 0.5 2.3 2 0 0 2 2 2 1 Telomerase ribonucleoprotein complex - RNA binding domain RVT_1 PF00078.27 ELR12717.1 - 9.1e-10 38.4 0.1 4.7e-05 23.0 0.0 3.2 4 1 0 4 4 4 2 Reverse transcriptase (RNA-dependent DNA polymerase) Clathrin_H_link PF13838.6 ELR12717.1 - 0.037 13.9 0.1 0.1 12.5 0.1 1.7 1 0 0 1 1 1 0 Clathrin-H-link CBS PF00571.28 ELR12719.1 - 3.2e-21 75.5 0.0 3.1e-10 40.3 0.0 4.5 4 1 0 4 4 4 3 CBS domain Casein PF00363.18 ELR12719.1 - 0.11 12.8 0.0 0.29 11.5 0.0 1.7 1 0 0 1 1 1 0 Casein HD_4 PF13328.6 ELR12720.1 - 4.3e-20 72.0 1.5 5.4e-20 71.7 0.3 1.8 2 0 0 2 2 2 1 HD domain HD PF01966.22 ELR12720.1 - 1.1e-05 25.7 4.1 1.1e-05 25.6 0.5 2.7 3 1 1 4 4 4 1 HD domain FtsK_gamma PF09397.10 ELR12720.1 - 4.7e-05 23.1 0.0 9.1e-05 22.2 0.0 1.5 1 0 0 1 1 1 1 Ftsk gamma domain DUF5399 PF17377.2 ELR12720.1 - 0.2 11.5 0.0 0.2 11.5 0.0 1.9 2 0 0 2 2 2 0 Family of unknown function (DUF5399) DUF4665 PF15679.5 ELR12720.1 - 5.2 7.7 10.3 1 10.0 3.6 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF4665) DUF913 PF06025.12 ELR12720.1 - 9.4 5.1 7.2 2.4 7.1 4.1 1.5 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) NMO PF03060.15 ELR12721.1 - 5e-45 154.3 5.6 4.4e-44 151.2 5.6 2.0 1 1 0 1 1 1 1 Nitronate monooxygenase FMN_dh PF01070.18 ELR12721.1 - 1.3e-08 34.3 6.9 1.3e-08 34.3 6.9 1.9 2 0 0 2 2 2 1 FMN-dependent dehydrogenase IMPDH PF00478.25 ELR12721.1 - 3.7e-08 32.7 0.0 5.3e-08 32.2 0.0 1.2 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain Herpes_pp85 PF04637.12 ELR12721.1 - 0.58 8.5 1.7 0.83 8.0 1.7 1.1 1 0 0 1 1 1 0 Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25) ApbA_C PF08546.11 ELR12723.1 - 3.3e-35 121.0 0.0 5.6e-35 120.3 0.0 1.4 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA C terminal ApbA PF02558.16 ELR12723.1 - 4e-27 94.7 0.2 6.3e-27 94.1 0.2 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA NAD_binding_2 PF03446.15 ELR12723.1 - 0.0001 22.5 0.6 0.00036 20.7 0.1 2.1 2 1 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase 2-Hacid_dh_C PF02826.19 ELR12723.1 - 0.00013 21.4 0.2 0.00055 19.3 0.1 2.1 2 1 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain F420_oxidored PF03807.17 ELR12723.1 - 0.00038 21.0 1.2 0.011 16.4 1.2 2.4 1 1 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent 3HCDH_N PF02737.18 ELR12723.1 - 0.0011 18.9 1.6 0.0013 18.7 0.6 1.7 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain ThiF PF00899.21 ELR12723.1 - 0.0051 16.2 0.6 0.0095 15.3 0.6 1.4 1 0 0 1 1 1 1 ThiF family NAD_binding_10 PF13460.6 ELR12723.1 - 0.014 15.3 0.6 0.042 13.7 0.1 1.9 1 1 1 2 2 2 0 NAD(P)H-binding NAD_Gly3P_dh_N PF01210.23 ELR12723.1 - 0.11 12.4 0.3 0.3 11.0 0.3 1.8 1 1 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus ADH_zinc_N PF00107.26 ELR12723.1 - 0.25 11.3 1.5 0.4 10.7 0.6 1.8 2 0 0 2 2 2 0 Zinc-binding dehydrogenase Rossmann-like PF10727.9 ELR12723.1 - 1.4 8.8 6.7 1.1 9.1 0.4 3.0 2 1 1 3 3 3 0 Rossmann-like domain RFX_DNA_binding PF02257.15 ELR12724.1 - 4.2e-14 52.9 0.1 1.4e-13 51.3 0.1 1.9 1 0 0 1 1 1 1 RFX DNA-binding domain Pox_D5 PF03288.16 ELR12724.1 - 0.14 12.7 0.1 0.32 11.5 0.1 1.5 1 0 0 1 1 1 0 Poxvirus D5 protein-like DUF1754 PF08555.10 ELR12725.1 - 0.025 15.4 14.8 0.025 15.4 14.8 2.4 2 0 0 2 2 2 0 Eukaryotic family of unknown function (DUF1754) Voldacs PF03517.13 ELR12725.1 - 0.15 12.1 11.0 0.29 11.3 11.0 1.4 1 0 0 1 1 1 0 Regulator of volume decrease after cellular swelling SAPS PF04499.15 ELR12725.1 - 0.96 8.2 5.3 1 8.0 5.3 1.2 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein BAF1_ABF1 PF04684.13 ELR12725.1 - 5.2 6.0 14.4 7.9 5.4 14.4 1.5 1 1 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor LRR_8 PF13855.6 ELR12726.1 - 7.1e-53 176.2 45.8 1.9e-09 37.2 1.1 9.2 6 2 4 11 11 11 9 Leucine rich repeat LRR_4 PF12799.7 ELR12726.1 - 3.2e-45 151.3 42.5 6.2e-06 26.5 0.1 11.4 8 2 5 13 13 13 12 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 ELR12726.1 - 2e-15 55.0 31.3 2 9.3 0.1 15.5 16 0 0 16 16 16 5 Leucine Rich Repeat LRR_6 PF13516.6 ELR12726.1 - 7.8e-09 34.9 43.9 0.64 10.2 0.0 13.6 15 0 0 15 15 15 6 Leucine Rich repeat LRR_9 PF14580.6 ELR12726.1 - 8.7e-06 25.3 23.8 0.082 12.4 3.0 6.3 2 2 6 8 8 8 6 Leucine-rich repeat LRR_5 PF13306.6 ELR12726.1 - 0.0035 17.3 0.1 14 5.7 0.0 3.5 3 0 0 3 3 3 2 BspA type Leucine rich repeat region (6 copies) CSTF_C PF14304.6 ELR12726.1 - 5.9 6.6 0.0 5.9 6.6 0.0 4.3 6 0 0 6 6 6 0 Transcription termination and cleavage factor C-terminal NLPC_P60 PF00877.19 ELR12727.1 - 8.1e-17 61.2 0.0 5.8e-16 58.4 0.0 2.0 1 1 0 2 2 2 1 NlpC/P60 family Ion_trans PF00520.31 ELR12728.1 - 1e-39 136.3 59.1 1.9e-29 102.6 27.0 2.2 2 0 0 2 2 2 2 Ion transport protein EF-hand_1 PF00036.32 ELR12728.1 - 1.9e-05 23.9 0.1 0.00041 19.7 0.1 2.6 2 0 0 2 2 2 1 EF hand EF-hand_7 PF13499.6 ELR12728.1 - 7.5e-05 23.1 0.2 0.00015 22.1 0.2 1.6 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 ELR12728.1 - 0.00085 19.1 0.2 0.33 11.0 0.1 2.9 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.6 ELR12728.1 - 0.023 14.5 0.1 0.17 11.8 0.1 2.3 2 0 0 2 2 2 0 EF-hand domain pair EF-hand_5 PF13202.6 ELR12728.1 - 0.048 13.2 0.2 0.57 9.8 0.1 2.4 2 0 0 2 2 2 0 EF hand Maelstrom PF13017.6 ELR12729.1 - 0.16 11.6 0.0 0.26 10.9 0.0 1.2 1 0 0 1 1 1 0 piRNA pathway germ-plasm component GATA PF00320.27 ELR12730.1 - 1.9e-06 27.4 2.4 8.5e-06 25.3 0.8 2.3 2 0 0 2 2 2 1 GATA zinc finger GvpH PF05455.11 ELR12730.1 - 0.019 15.0 0.4 0.47 10.5 0.0 2.2 2 0 0 2 2 2 0 GvpH Sporozoite_P67 PF05642.11 ELR12730.1 - 5.9 4.8 7.3 8 4.4 7.3 1.2 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Amidase PF01425.21 ELR12731.1 - 1.8e-89 300.8 0.0 2.2e-89 300.5 0.0 1.1 1 0 0 1 1 1 1 Amidase Tubulin PF00091.25 ELR12732.1 - 1.9e-67 227.3 0.0 3e-67 226.7 0.0 1.3 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 ELR12732.1 - 4.4e-46 156.2 0.0 7.3e-46 155.4 0.0 1.4 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.6 ELR12732.1 - 7.3e-05 22.5 0.0 0.00015 21.5 0.0 1.5 1 0 0 1 1 1 1 Tubulin domain Sld5 PF05916.11 ELR12733.1 - 0.0023 18.4 0.0 0.0067 16.9 0.0 1.9 2 1 0 2 2 2 1 GINS complex protein CsbD PF05532.12 ELR12734.1 - 1.4 8.9 5.6 0.3 11.0 0.2 2.4 3 0 0 3 3 3 0 CsbD-like Herpes_UL52 PF03121.15 ELR12735.1 - 1.4e-14 53.8 0.1 2.7e-14 52.9 0.1 1.5 1 0 0 1 1 1 1 Herpesviridae UL52/UL70 DNA primase ArfGap PF01412.18 ELR12738.1 - 4.2e-17 62.3 0.5 4.2e-17 62.3 0.5 5.5 5 3 2 7 7 7 1 Putative GTPase activating protein for Arf F-box-like PF12937.7 ELR12739.1 - 4.4e-13 48.9 1.3 1.3e-12 47.4 1.3 1.9 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ELR12739.1 - 4.3e-08 32.8 0.7 1e-07 31.6 0.7 1.7 1 0 0 1 1 1 1 F-box domain TPR_4 PF07721.14 ELR12739.1 - 0.004 17.6 0.1 0.017 15.7 0.1 2.1 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_8 PF13181.6 ELR12739.1 - 0.021 15.0 0.2 0.021 15.0 0.2 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat F-box_5 PF18511.1 ELR12739.1 - 0.025 14.1 2.2 0.037 13.6 0.0 2.2 2 0 0 2 2 2 0 F-box TPR_17 PF13431.6 ELR12739.1 - 0.034 14.5 0.2 0.11 13.0 0.2 1.9 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_10 PF13374.6 ELR12739.1 - 0.056 13.3 0.6 0.25 11.3 0.6 2.2 1 0 0 1 1 1 0 Tetratricopeptide repeat ANAPC3 PF12895.7 ELR12739.1 - 0.11 12.7 0.6 0.38 11.0 0.6 1.9 1 0 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.6 ELR12739.1 - 0.99 10.0 3.7 1.1 9.8 0.9 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_1 PF00515.28 ELR12739.1 - 1.1 9.1 12.5 0.11 12.4 0.4 4.1 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_12 PF13424.6 ELR12739.1 - 2.1 8.7 10.7 0.48 10.7 0.6 3.9 5 0 0 5 5 5 0 Tetratricopeptide repeat ELO PF01151.18 ELR12740.1 - 2.5e-58 197.6 20.2 3e-58 197.3 20.2 1.0 1 0 0 1 1 1 1 GNS1/SUR4 family Aldo_ket_red PF00248.21 ELR12741.1 - 9.2e-33 113.7 0.9 2.5e-16 59.8 0.0 3.0 2 1 0 2 2 2 2 Aldo/keto reductase family D123 PF07065.14 ELR12742.1 - 1.3e-15 57.4 0.1 3.3e-15 56.1 0.1 1.7 1 1 0 1 1 1 1 D123 R2K_2 PF18299.1 ELR12742.1 - 6e-08 32.7 0.0 1.3e-07 31.6 0.0 1.5 1 0 0 1 1 1 1 ATP-grasp domain, R2K clade family 2 R2K_3 PF14243.6 ELR12742.1 - 0.00019 21.5 0.0 0.00042 20.4 0.0 1.6 1 0 0 1 1 1 1 ATP-grasp domain, R2K clade family 3 NIF PF03031.18 ELR12744.1 - 5.5e-37 126.9 0.0 9e-37 126.2 0.0 1.3 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase DUF2321 PF10083.9 ELR12744.1 - 0.2 11.3 0.9 1.3 8.7 0.4 2.2 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2321) Peptidase_S49_N PF08496.10 ELR12744.1 - 1.6 8.8 5.2 0.23 11.5 1.0 1.7 2 0 0 2 2 2 0 Peptidase family S49 N-terminal YqzE PF14038.6 ELR12744.1 - 3.7 7.6 8.9 0.7 9.9 4.3 2.2 2 0 0 2 2 2 0 YqzE-like protein UAA PF08449.11 ELR12745.1 - 3.9e-56 190.5 22.7 6e-55 186.6 22.7 2.0 1 1 0 1 1 1 1 UAA transporter family TRAUB PF08164.12 ELR12746.1 - 1.9e-21 76.3 0.1 1.9e-21 76.3 0.1 4.3 4 0 0 4 4 4 1 Apoptosis-antagonizing transcription factor, C-terminal AATF-Che1 PF13339.6 ELR12746.1 - 2e-12 47.9 14.4 2e-12 47.9 14.4 6.1 3 3 0 3 3 3 1 Apoptosis antagonizing transcription factor FHIPEP PF00771.20 ELR12746.1 - 5.3 5.4 6.0 14 4.0 1.1 2.5 1 1 1 2 2 2 0 FHIPEP family SRP40_C PF05022.12 ELR12747.1 - 1.2e-08 35.7 8.1 1.2e-08 35.7 8.1 6.2 4 3 0 4 4 4 1 SRP40, C-terminal domain SR-25 PF10500.9 ELR12747.1 - 0.64 9.6 137.7 0.035 13.7 66.2 4.6 1 1 3 4 4 4 0 Nuclear RNA-splicing-associated protein DPPIV_N PF00930.21 ELR12748.1 - 2.8e-69 233.5 6.5 4.5e-69 232.9 6.5 1.3 1 0 0 1 1 1 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region Peptidase_S9 PF00326.21 ELR12748.1 - 4.8e-29 101.4 8.0 4.6e-21 75.3 3.0 2.4 1 1 1 2 2 2 2 Prolyl oligopeptidase family WD40 PF00400.32 ELR12749.1 - 1.1e-05 26.1 6.8 0.0012 19.7 0.1 4.8 4 1 0 4 4 4 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ELR12749.1 - 0.00014 22.1 0.2 0.073 13.4 0.0 3.4 3 2 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain DivIC PF04977.15 ELR12750.1 - 3.7e-06 26.6 0.0 4.8e-06 26.2 0.0 1.2 1 0 0 1 1 1 1 Septum formation initiator HALZ PF02183.18 ELR12750.1 - 0.00012 22.2 0.8 0.00026 21.1 0.8 1.5 1 0 0 1 1 1 1 Homeobox associated leucine zipper bZIP_1 PF00170.21 ELR12750.1 - 0.00019 21.5 0.3 0.00032 20.7 0.3 1.3 1 0 0 1 1 1 1 bZIP transcription factor CCDC92 PF14916.6 ELR12750.1 - 0.00056 19.6 0.2 0.0008 19.1 0.2 1.3 1 0 0 1 1 1 1 Coiled-coil domain of unknown function Taxilin PF09728.9 ELR12750.1 - 0.005 16.1 0.3 0.0052 16.0 0.3 1.1 1 0 0 1 1 1 1 Myosin-like coiled-coil protein TSC22 PF01166.18 ELR12750.1 - 0.008 16.5 0.2 0.012 15.9 0.2 1.3 1 0 0 1 1 1 1 TSC-22/dip/bun family Fungal_TACC PF12709.7 ELR12750.1 - 0.03 14.8 0.3 0.049 14.1 0.3 1.3 1 0 0 1 1 1 0 Fungal Transforming acidic coiled-coil (TACC) proteins FlaC_arch PF05377.11 ELR12750.1 - 0.055 13.9 0.1 0.091 13.2 0.1 1.3 1 0 0 1 1 1 0 Flagella accessory protein C (FlaC) DUF4200 PF13863.6 ELR12750.1 - 0.067 13.6 0.1 0.08 13.3 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4200) bZIP_2 PF07716.15 ELR12750.1 - 0.12 12.5 0.5 0.18 11.9 0.5 1.2 1 0 0 1 1 1 0 Basic region leucine zipper SCP2 PF02036.17 ELR12751.1 - 8.6e-22 77.5 0.3 1.3e-21 76.9 0.3 1.3 1 0 0 1 1 1 1 SCP-2 sterol transfer family Thiolase_N PF00108.23 ELR12751.1 - 5.7e-21 75.0 0.0 4.7e-19 68.8 0.0 2.8 2 1 0 2 2 2 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 ELR12751.1 - 1.4e-11 44.1 0.1 1.3e-10 41.0 0.1 2.5 2 1 0 2 2 2 1 Thiolase, C-terminal domain Alkyl_sulf_C PF14864.6 ELR12751.1 - 0.00056 20.2 0.0 0.00095 19.4 0.0 1.3 1 0 0 1 1 1 1 Alkyl sulfatase C-terminal ACP_syn_III PF08545.10 ELR12751.1 - 0.0021 17.9 0.9 0.13 12.1 0.0 2.9 3 0 0 3 3 3 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III Vert_IL3-reg_TF PF06529.11 ELR12751.1 - 0.0074 15.5 0.0 0.012 14.8 0.0 1.2 1 0 0 1 1 1 1 Vertebrate interleukin-3 regulated transcription factor Ketoacyl-synt_C PF02801.22 ELR12751.1 - 0.019 15.0 0.1 1.3 9.1 0.0 2.8 2 0 0 2 2 2 0 Beta-ketoacyl synthase, C-terminal domain SpoVAD PF07451.11 ELR12751.1 - 0.023 13.4 0.0 0.08 11.6 0.0 1.8 2 0 0 2 2 2 0 Stage V sporulation protein AD (SpoVAD) ketoacyl-synt PF00109.26 ELR12751.1 - 0.048 13.2 0.2 0.39 10.3 0.2 2.2 1 1 0 1 1 1 0 Beta-ketoacyl synthase, N-terminal domain WD40 PF00400.32 ELR12752.1 - 8.2e-35 118.3 32.8 8.7e-07 29.5 0.8 11.3 11 1 0 11 11 11 8 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ELR12752.1 - 8.8e-06 25.9 6.6 0.089 13.1 0.1 6.3 4 3 3 7 7 7 3 Anaphase-promoting complex subunit 4 WD40 domain LigB PF02900.18 ELR12753.1 - 3.6e-41 141.0 0.1 4.1e-41 140.9 0.1 1.0 1 0 0 1 1 1 1 Catalytic LigB subunit of aromatic ring-opening dioxygenase U-box PF04564.15 ELR12754.1 - 1.7e-08 34.5 0.1 7.6e-08 32.4 0.0 2.1 2 0 0 2 2 2 1 U-box domain DUF1296 PF06972.11 ELR12754.1 - 1.1e-07 31.9 0.2 3.5e-07 30.3 0.2 1.9 1 0 0 1 1 1 1 Protein of unknown function (DUF1296) Myb_DNA-binding PF00249.31 ELR12754.1 - 0.00031 20.9 0.7 0.0073 16.5 0.0 2.8 2 0 0 2 2 2 1 Myb-like DNA-binding domain DUF1421 PF07223.11 ELR12754.1 - 0.086 12.7 0.0 1.8 8.4 0.0 2.3 2 0 0 2 2 2 0 UBA-like domain (DUF1421) Act-Frag_cataly PF09192.10 ELR12755.1 - 1.4e-38 132.9 0.0 1.8e-38 132.6 0.0 1.1 1 0 0 1 1 1 1 Actin-fragmin kinase, catalytic HipA_C PF07804.12 ELR12755.1 - 0.16 11.7 0.0 0.37 10.5 0.0 1.7 2 0 0 2 2 2 0 HipA-like C-terminal domain Metallophos PF00149.28 ELR12756.1 - 2.5e-08 34.6 0.2 7.5e-08 33.1 0.0 1.8 1 1 1 2 2 2 1 Calcineurin-like phosphoesterase HECT_2 PF09814.9 ELR12758.1 - 5.4e-19 68.3 0.0 1e-16 60.8 0.0 2.3 1 1 1 2 2 2 2 HECT-like Ubiquitin-conjugating enzyme (E2)-binding zf-MYND PF01753.18 ELR12758.1 - 2.8e-08 33.7 7.5 2.8e-08 33.7 7.5 2.3 2 0 0 2 2 2 1 MYND finger RNA_pol_N PF01194.17 ELR12759.1 - 2.7e-13 50.0 0.2 3.3e-13 49.7 0.2 1.2 1 0 0 1 1 1 1 RNA polymerases N / 8 kDa subunit PARP PF00644.20 ELR12760.1 - 3.2e-08 33.4 0.0 3.4e-07 30.0 0.0 2.3 1 1 1 2 2 2 1 Poly(ADP-ribose) polymerase catalytic domain Exotox-A_cataly PF09009.10 ELR12760.1 - 0.02 14.7 0.0 0.041 13.6 0.0 1.5 1 0 0 1 1 1 0 Exotoxin A catalytic TFIIF_alpha PF05793.12 ELR12760.1 - 0.049 12.2 25.0 0.074 11.6 25.0 1.3 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) TP53IP5 PF15331.6 ELR12761.1 - 4.2 7.4 20.7 2.5 8.2 3.0 2.3 2 0 0 2 2 2 0 Cellular tumour antigen p53-inducible 5 Arf PF00025.21 ELR12762.1 - 4.8e-70 234.6 0.2 5.5e-70 234.3 0.2 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 ELR12762.1 - 2.2e-14 53.7 0.0 2.9e-14 53.3 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 ELR12762.1 - 6.6e-13 48.6 0.0 7.4e-13 48.4 0.0 1.1 1 0 0 1 1 1 1 Ras family SRPRB PF09439.10 ELR12762.1 - 4.5e-12 45.8 0.0 5.8e-12 45.4 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.20 ELR12762.1 - 6.3e-12 45.3 0.4 3.7e-08 32.9 0.2 2.5 1 1 1 2 2 2 2 G-protein alpha subunit Gtr1_RagA PF04670.12 ELR12762.1 - 8.8e-10 38.3 0.0 1.1e-09 38.1 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 ELR12762.1 - 3.2e-05 24.0 0.0 4.6e-05 23.5 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase 6PF2K PF01591.18 ELR12762.1 - 0.08 12.2 0.1 0.15 11.3 0.1 1.3 1 1 0 1 1 1 0 6-phosphofructo-2-kinase cobW PF02492.19 ELR12762.1 - 0.14 11.7 0.0 1 8.9 0.0 1.9 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Pkinase PF00069.25 ELR12763.1 - 1.2e-65 221.5 0.0 1.6e-65 221.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR12763.1 - 2.8e-48 164.5 0.0 4e-48 164.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 ELR12763.1 - 6.4e-07 28.5 1.4 8.3e-07 28.1 0.0 1.7 2 0 0 2 2 2 1 Fungal protein kinase Kinase-like PF14531.6 ELR12763.1 - 0.0013 18.2 0.0 0.0032 16.8 0.0 1.6 1 1 0 1 1 1 1 Kinase-like KIND PF16474.5 ELR12763.1 - 0.025 14.5 0.0 0.025 14.5 0.0 2.8 4 0 0 4 4 4 0 Kinase non-catalytic C-lobe domain Haspin_kinase PF12330.8 ELR12763.1 - 0.043 12.8 0.1 0.99 8.3 0.0 2.1 2 0 0 2 2 2 0 Haspin like kinase domain TFIIF_alpha PF05793.12 ELR12763.1 - 0.87 8.1 27.5 1.3 7.5 27.5 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) DNA_pol_phi PF04931.13 ELR12763.1 - 4.4 5.3 18.4 6.2 4.8 18.4 1.1 1 0 0 1 1 1 0 DNA polymerase phi zf-CCHC_3 PF13917.6 ELR12764.1 - 0.0042 17.0 0.2 0.0087 16.0 0.2 1.6 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC PF00098.23 ELR12764.1 - 0.017 15.2 1.1 0.033 14.3 1.1 1.5 1 0 0 1 1 1 0 Zinc knuckle CCDC71L PF15374.6 ELR12764.1 - 0.04 13.2 11.2 0.043 13.1 11.2 1.1 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 71L Sortilin-Vps10 PF15902.5 ELR12766.1 - 1.1e-09 37.6 1.8 1.5e-05 24.0 0.0 2.8 2 1 1 3 3 3 3 Sortilin, neurotensin receptor 3, BNR PF02012.20 ELR12766.1 - 2.9e-07 29.5 10.9 0.2 11.8 0.8 5.0 4 0 0 4 4 4 3 BNR/Asp-box repeat BNR_2 PF13088.6 ELR12766.1 - 5.9e-05 22.5 4.2 0.00034 20.0 4.2 2.1 1 1 0 1 1 1 1 BNR repeat-like domain D123 PF07065.14 ELR12767.1 - 7.8e-25 87.7 0.4 2e-19 69.9 0.1 3.0 2 1 1 3 3 3 2 D123 R2K_3 PF14243.6 ELR12767.1 - 7.8e-07 29.3 0.2 2.8e-06 27.5 0.0 1.9 2 0 0 2 2 2 1 ATP-grasp domain, R2K clade family 3 R2K_2 PF18299.1 ELR12767.1 - 4.9e-05 23.2 0.1 0.00014 21.7 0.0 1.8 2 0 0 2 2 2 1 ATP-grasp domain, R2K clade family 2 Dynamin_N PF00350.23 ELR12768.1 - 8.1e-22 78.1 8.1 6.3e-11 42.6 0.1 3.4 3 2 1 4 4 4 2 Dynamin family MMR_HSR1 PF01926.23 ELR12768.1 - 5.6e-13 49.0 1.7 2e-11 44.0 0.0 3.5 3 1 0 3 3 3 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 ELR12768.1 - 3.2e-06 27.1 0.8 0.072 13.0 0.0 3.3 1 1 1 3 3 3 2 RsgA GTPase GTP_EFTU PF00009.27 ELR12768.1 - 2.9e-05 23.7 0.1 0.00021 20.9 0.1 2.4 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain FeoB_N PF02421.18 ELR12768.1 - 0.00012 21.7 0.3 0.058 12.9 0.1 2.5 2 0 0 2 2 2 2 Ferrous iron transport protein B AIG1 PF04548.16 ELR12768.1 - 0.0004 19.8 4.2 0.0014 18.0 0.8 3.2 3 1 0 3 3 3 1 AIG1 family ABC_tran PF00005.27 ELR12768.1 - 0.0018 18.8 0.0 0.031 14.8 0.0 2.8 1 1 1 2 2 2 1 ABC transporter PduV-EutP PF10662.9 ELR12768.1 - 0.0083 15.9 0.0 0.03 14.1 0.0 1.9 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation Roc PF08477.13 ELR12768.1 - 0.0084 16.3 0.1 0.079 13.2 0.1 2.4 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Gtr1_RagA PF04670.12 ELR12768.1 - 0.017 14.5 2.0 0.032 13.6 0.0 2.4 3 0 0 3 3 3 0 Gtr1/RagA G protein conserved region cobW PF02492.19 ELR12768.1 - 0.086 12.4 2.1 0.5 9.9 0.0 2.6 3 0 0 3 3 3 0 CobW/HypB/UreG, nucleotide-binding domain Septin PF00735.18 ELR12768.1 - 0.14 11.4 2.3 0.22 10.7 0.0 2.5 4 0 0 4 4 4 0 Septin Ras PF00071.22 ELR12768.1 - 0.25 10.9 1.5 1.1 8.9 0.1 2.6 2 1 0 2 2 2 0 Ras family AAA_23 PF13476.6 ELR12768.1 - 0.84 10.1 14.5 8.9 6.7 0.3 3.7 2 1 1 3 3 3 0 AAA domain WD40 PF00400.32 ELR12770.1 - 2.2e-28 97.9 6.5 8.7e-06 26.4 0.5 6.6 6 1 1 7 7 7 5 WD domain, G-beta repeat LisH_TPL PF17814.1 ELR12770.1 - 1.3e-13 50.3 0.4 2.4e-13 49.5 0.4 1.5 1 0 0 1 1 1 1 LisH-like dimerisation domain ANAPC4_WD40 PF12894.7 ELR12770.1 - 4.2e-11 43.0 0.3 0.00062 20.0 0.0 4.8 1 1 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ELR12770.1 - 8.6e-06 25.3 1.0 0.0097 15.3 0.0 2.6 1 1 0 2 2 2 2 WD40-like domain Ge1_WD40 PF16529.5 ELR12770.1 - 0.00047 19.2 2.0 0.35 9.8 0.1 3.3 2 1 1 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein PQQ_3 PF13570.6 ELR12770.1 - 0.0021 18.5 0.1 0.036 14.5 0.0 2.8 3 0 0 3 3 3 1 PQQ-like domain BBS2_Mid PF14783.6 ELR12770.1 - 0.0054 16.7 0.1 15 5.6 0.0 4.0 3 1 1 4 4 4 2 Ciliary BBSome complex subunit 2, middle region PAP2_3 PF14378.6 ELR12771.1 - 1.5e-13 50.9 9.0 1.5e-13 50.9 9.0 2.7 3 0 0 3 3 3 1 PAP2 superfamily PAP2 PF01569.21 ELR12771.1 - 1.3e-08 34.7 6.3 1.3e-08 34.7 6.3 2.7 2 1 0 2 2 2 1 PAP2 superfamily PAP2_C PF14360.6 ELR12771.1 - 0.00037 21.0 2.3 0.00037 21.0 2.3 2.6 2 0 0 2 2 2 1 PAP2 superfamily C-terminal DUF3040 PF11239.8 ELR12771.1 - 0.41 11.0 0.0 0.41 11.0 0.0 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF3040) AI-2E_transport PF01594.16 ELR12771.1 - 3.4 6.7 15.2 0.41 9.8 0.5 3.2 3 0 0 3 3 3 0 AI-2E family transporter PAS_9 PF13426.7 ELR12772.1 - 0.00056 20.1 0.0 0.0018 18.5 0.0 1.8 1 1 0 1 1 1 1 PAS domain PAS PF00989.25 ELR12772.1 - 0.0011 19.0 1.1 0.0039 17.2 0.0 2.4 3 0 0 3 3 3 1 PAS fold PAS_3 PF08447.12 ELR12772.1 - 0.011 15.9 0.0 0.044 14.1 0.0 2.0 2 0 0 2 2 2 0 PAS fold BBP1_C PF15272.6 ELR12772.1 - 0.025 14.4 0.5 0.025 14.4 0.5 1.7 2 0 0 2 2 2 0 Spindle pole body component BBP1, C-terminal YabA PF06156.13 ELR12772.1 - 0.073 13.7 2.0 0.39 11.4 0.1 2.3 2 0 0 2 2 2 0 Initiation control protein YabA Rhamno_transf PF11316.8 ELR12772.1 - 1.1 8.5 4.0 0.23 10.8 0.2 1.7 2 0 0 2 2 2 0 Putative rhamnosyl transferase HALZ PF02183.18 ELR12773.1 - 0.0074 16.5 3.3 0.19 12.0 0.3 2.5 1 1 1 2 2 2 2 Homeobox associated leucine zipper PAS_9 PF13426.7 ELR12773.1 - 0.025 14.8 0.0 0.065 13.5 0.0 1.7 1 0 0 1 1 1 0 PAS domain DUF4515 PF14988.6 ELR12773.1 - 0.038 13.8 0.1 0.06 13.2 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4515) PAS_3 PF08447.12 ELR12773.1 - 0.09 13.1 0.0 0.26 11.6 0.0 1.8 1 1 0 1 1 1 0 PAS fold bZIP_2 PF07716.15 ELR12773.1 - 0.33 11.1 3.4 3.1 7.9 0.2 2.4 1 1 1 2 2 2 0 Basic region leucine zipper GON PF08685.11 ELR12774.1 - 5.4e-06 26.4 0.2 2.2e-05 24.4 0.2 1.8 1 1 0 1 1 1 1 GON domain Exostosin PF03016.15 ELR12775.1 - 2.9e-20 72.7 0.0 1.7e-19 70.1 0.0 2.0 1 1 0 1 1 1 1 Exostosin family GON PF08685.11 ELR12776.1 - 7.1e-06 26.0 0.1 3e-05 24.0 0.1 1.8 1 1 0 1 1 1 1 GON domain tRNA-synt_1b PF00579.25 ELR12777.1 - 1.7e-21 76.8 0.0 2.7e-21 76.2 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) HhH-GPD PF00730.25 ELR12778.1 - 5.1e-10 39.8 0.0 1e-09 38.8 0.0 1.5 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein EndIII_4Fe-2S PF10576.9 ELR12778.1 - 1.3e-06 28.5 4.7 2.5e-06 27.6 4.7 1.5 1 0 0 1 1 1 1 Iron-sulfur binding domain of endonuclease III CDC45 PF02724.14 ELR12778.1 - 1.2 7.3 32.3 0.8 7.9 11.8 2.2 2 0 0 2 2 2 0 CDC45-like protein RasGAP PF00616.19 ELR12779.1 - 4e-16 59.4 3.7 5.2e-10 39.4 0.0 3.0 2 2 1 3 3 3 2 GTPase-activator protein for Ras-like GTPase PAS_9 PF13426.7 ELR12779.1 - 7.2e-12 45.5 0.0 2.2e-11 43.9 0.0 1.9 1 0 0 1 1 1 1 PAS domain PH PF00169.29 ELR12779.1 - 5.4e-08 33.3 0.3 2.6e-07 31.1 0.1 2.1 2 0 0 2 2 2 1 PH domain PAS PF00989.25 ELR12779.1 - 2.9e-05 24.0 0.0 6.2e-05 23.0 0.0 1.6 1 0 0 1 1 1 1 PAS fold PAS_4 PF08448.10 ELR12779.1 - 6.7e-05 23.1 0.0 0.00021 21.5 0.0 1.8 2 0 0 2 2 2 1 PAS fold PH_11 PF15413.6 ELR12779.1 - 0.0017 18.8 1.1 0.0058 17.0 0.0 2.5 2 1 0 2 2 2 1 Pleckstrin homology domain PH_9 PF15410.6 ELR12779.1 - 0.013 15.8 0.0 0.032 14.6 0.0 1.7 1 0 0 1 1 1 0 Pleckstrin homology domain Phasin PF05597.11 ELR12779.1 - 0.053 13.5 1.6 0.11 12.5 0.1 2.2 2 0 0 2 2 2 0 Poly(hydroxyalcanoate) granule associated protein (phasin) G-alpha PF00503.20 ELR12780.1 - 5e-96 321.9 6.2 5.7e-96 321.7 6.2 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 ELR12780.1 - 1.2e-14 54.1 0.8 1.8e-11 43.8 0.0 2.8 3 0 0 3 3 3 2 ADP-ribosylation factor family Roc PF08477.13 ELR12780.1 - 0.0027 17.9 0.0 3.2 8.0 0.0 2.7 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase DUF3173 PF11372.8 ELR12780.1 - 0.014 15.3 0.0 0.077 12.9 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3173) GTP_EFTU PF00009.27 ELR12780.1 - 0.019 14.5 2.2 0.16 11.4 0.3 3.0 2 2 0 2 2 2 0 Elongation factor Tu GTP binding domain Sigma54_activat PF00158.26 ELR12780.1 - 0.13 11.9 0.8 0.7 9.6 0.2 2.1 2 0 0 2 2 2 0 Sigma-54 interaction domain Kelch_3 PF13415.6 ELR12781.1 - 5e-20 71.3 8.9 3.1e-09 36.9 0.2 4.8 5 0 0 5 5 5 4 Galactose oxidase, central domain Kelch_5 PF13854.6 ELR12781.1 - 2.7e-15 55.9 3.7 0.0011 18.9 0.1 5.8 6 0 0 6 6 6 3 Kelch motif Kelch_2 PF07646.15 ELR12781.1 - 1.7e-12 46.8 12.7 0.041 13.9 0.1 6.6 6 1 0 6 6 6 5 Kelch motif Kelch_4 PF13418.6 ELR12781.1 - 2e-12 46.9 15.3 0.0054 16.7 0.0 6.3 6 1 1 7 7 7 3 Galactose oxidase, central domain Kelch_6 PF13964.6 ELR12781.1 - 5.3e-12 45.6 7.6 0.011 16.0 0.1 6.0 5 1 1 6 6 6 4 Kelch motif Kelch_1 PF01344.25 ELR12781.1 - 6.8e-11 41.6 1.3 0.0002 20.9 0.1 4.9 4 0 0 4 4 4 3 Kelch motif Reg_prop PF07494.11 ELR12782.1 - 0.002 18.1 0.1 19 5.9 0.0 4.6 4 0 0 4 4 4 2 Two component regulator propeller Ank_2 PF12796.7 ELR12783.1 - 3.7e-15 56.3 0.1 6.7e-12 45.8 0.1 2.4 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ELR12783.1 - 2.1e-13 50.5 0.2 2.3e-08 34.4 0.0 2.7 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.30 ELR12783.1 - 5.7e-13 48.7 0.8 4.2e-07 30.1 0.0 3.5 3 1 1 4 4 4 2 Ankyrin repeat Ank_5 PF13857.6 ELR12783.1 - 2.1e-12 47.0 1.4 6.3e-10 39.1 0.2 2.5 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 ELR12783.1 - 2.6e-11 42.7 0.1 2.4e-05 24.4 0.0 3.7 3 0 0 3 3 3 2 Ankyrin repeat WD40 PF00400.32 ELR12783.1 - 4.9e-07 30.4 21.0 0.04 14.8 0.3 7.2 7 0 0 7 7 7 3 WD domain, G-beta repeat DUF874 PF05917.11 ELR12783.1 - 0.0084 15.2 0.4 0.014 14.5 0.4 1.3 1 0 0 1 1 1 1 Helicobacter pylori protein of unknown function (DUF874) PQQ_3 PF13570.6 ELR12783.1 - 0.024 15.1 0.2 21 5.8 0.8 4.5 5 0 0 5 5 5 0 PQQ-like domain DUF627 PF04781.12 ELR12783.1 - 0.12 12.4 0.1 0.25 11.4 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF627) DEAD PF00270.29 ELR12784.1 - 7.3e-22 78.0 0.1 3e-21 76.0 0.0 1.9 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ELR12784.1 - 1.9e-16 60.3 0.0 1.3e-15 57.7 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain TetR_C_15 PF17918.1 ELR12784.1 - 0.062 14.1 0.3 1.2 9.9 0.1 2.7 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain DUF1168 PF06658.12 ELR12784.1 - 1.1 9.1 5.5 2.4 8.0 5.5 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1168) FLILHELTA PF10306.9 ELR12785.1 - 0.06 13.8 0.9 0.15 12.4 0.9 1.6 1 0 0 1 1 1 0 Hypothetical protein FLILHELTA Stn1 PF10451.9 ELR12786.1 - 0.2 10.6 1.3 0.21 10.5 1.3 1.0 1 0 0 1 1 1 0 Telomere regulation protein Stn1 Ras PF00071.22 ELR12787.1 - 3e-19 69.2 0.0 3.8e-19 68.8 0.0 1.1 1 0 0 1 1 1 1 Ras family zf-C2H2_2 PF12756.7 ELR12788.1 - 5.5e-27 94.1 6.3 1e-25 90.0 0.3 2.7 3 0 0 3 3 3 2 C2H2 type zinc-finger (2 copies) zf-C2H2_jaz PF12171.8 ELR12788.1 - 0.039 14.3 3.1 1.5 9.2 0.2 3.0 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding zf-LYAR PF08790.11 ELR12788.1 - 0.042 13.8 6.1 4.1 7.4 0.0 3.6 3 0 0 3 3 3 0 LYAR-type C2HC zinc finger zf-C2H2 PF00096.26 ELR12788.1 - 0.058 13.9 5.3 0.74 10.4 0.4 2.7 2 0 0 2 2 2 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 ELR12788.1 - 0.081 13.8 5.5 0.2 12.6 0.1 3.1 3 0 0 3 3 3 0 C2H2-type zinc finger HTH_8 PF02954.19 ELR12788.1 - 0.91 9.4 3.6 1.2 9.0 0.1 2.5 2 0 0 2 2 2 0 Bacterial regulatory protein, Fis family FYDLN_acid PF09538.10 ELR12788.1 - 2.6 8.8 0.0 2.6 8.8 0.0 3.0 3 1 0 3 3 3 0 Protein of unknown function (FYDLN_acid) VWA PF00092.28 ELR12789.1 - 3.3e-08 34.0 0.0 5.6e-07 30.0 0.0 3.0 4 0 0 4 4 4 1 von Willebrand factor type A domain VWA_2 PF13519.6 ELR12789.1 - 2e-06 28.4 0.0 4.5e-05 24.1 0.0 3.4 4 0 0 4 4 4 1 von Willebrand factor type A domain F-box-like PF12937.7 ELR12789.1 - 1.1e-05 25.2 0.0 2.8e-05 23.9 0.0 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ELR12789.1 - 0.00016 21.4 0.1 0.00044 20.0 0.1 1.7 1 0 0 1 1 1 1 F-box domain CCDC32 PF14989.6 ELR12789.1 - 0.013 15.5 0.0 0.04 13.9 0.0 1.8 1 0 0 1 1 1 0 Coiled-coil domain containing 32 TolA_bind_tri PF16331.5 ELR12789.1 - 0.084 13.0 0.0 0.23 11.5 0.0 1.8 1 0 0 1 1 1 0 TolA binding protein trimerisation ADIP PF11559.8 ELR12789.1 - 0.37 10.9 2.1 0.68 10.0 0.1 2.2 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding Histone_HNS PF00816.21 ELR12789.1 - 5.3 7.9 8.0 0.63 10.9 0.2 3.2 3 1 0 3 3 3 0 H-NS histone family Peptidase_S10 PF00450.22 ELR12791.1 - 1.2e-117 393.9 0.0 1.4e-117 393.7 0.0 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase Glyoxalase PF00903.25 ELR12792.1 - 2e-25 89.5 0.0 2.5e-25 89.2 0.0 1.1 1 0 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_4 PF13669.6 ELR12792.1 - 2.7e-07 30.8 0.0 1e-06 28.9 0.0 1.8 1 1 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_6 PF18029.1 ELR12792.1 - 7.7e-07 29.9 0.0 1e-06 29.5 0.0 1.2 1 0 0 1 1 1 1 Glyoxalase-like domain Glyoxalase_2 PF12681.7 ELR12792.1 - 0.018 15.0 0.0 4.5 7.2 0.0 2.2 2 0 0 2 2 2 0 Glyoxalase-like domain PIG-X PF08320.12 ELR12792.1 - 0.099 12.5 0.0 0.16 11.9 0.0 1.3 1 0 0 1 1 1 0 PIG-X / PBN1 DTHCT PF08070.11 ELR12793.1 - 0.13 13.1 4.6 0.28 12.0 4.6 1.5 1 0 0 1 1 1 0 DTHCT (NUC029) region Glyco_hydro_125 PF06824.11 ELR12794.1 - 7.8e-156 519.1 0.0 9e-156 518.9 0.0 1.0 1 0 0 1 1 1 1 Metal-independent alpha-mannosidase (GH125) DEAD PF00270.29 ELR12795.1 - 8.7e-16 58.2 0.1 2.8e-14 53.3 0.1 2.2 1 1 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ELR12795.1 - 4.7e-07 30.1 0.1 2.1e-06 28.0 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain AAA_19 PF13245.6 ELR12795.1 - 0.03 14.7 0.0 0.1 12.9 0.0 1.9 1 0 0 1 1 1 0 AAA domain Dec-1 PF04624.14 ELR12795.1 - 0.67 9.9 5.4 1.7 8.5 5.4 1.7 1 0 0 1 1 1 0 Dec-1 repeat AATF-Che1 PF13339.6 ELR12796.1 - 0.014 16.1 3.4 0.85 10.3 0.3 3.3 2 1 1 3 3 3 0 Apoptosis antagonizing transcription factor MIF4G_like_2 PF09090.11 ELR12796.1 - 0.041 13.3 4.8 0.095 12.2 0.2 2.4 2 0 0 2 2 2 0 MIF4G like DUF4094 PF13334.6 ELR12796.1 - 0.13 12.7 0.5 0.69 10.4 0.4 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4094) FHIPEP PF00771.20 ELR12796.1 - 0.22 9.9 0.1 0.34 9.3 0.1 1.2 1 0 0 1 1 1 0 FHIPEP family DUF2207 PF09972.9 ELR12796.1 - 0.26 10.0 2.4 0.51 9.0 0.5 1.8 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) Ctr PF04145.15 ELR12796.1 - 0.52 10.9 2.2 0.7 10.5 0.1 2.1 2 1 0 2 2 2 0 Ctr copper transporter family Ten1_2 PF15490.6 ELR12797.1 - 7.3e-29 99.9 0.0 8.7e-29 99.6 0.0 1.0 1 0 0 1 1 1 1 Telomere-capping, CST complex subunit Rep_fac-A_3 PF08661.11 ELR12797.1 - 0.0001 22.6 0.0 0.00014 22.2 0.0 1.1 1 0 0 1 1 1 1 Replication factor A protein 3 Ten1 PF12658.7 ELR12797.1 - 0.0085 16.0 0.0 0.013 15.4 0.0 1.3 1 1 0 1 1 1 1 Telomere capping, CST complex subunit DUF3324 PF11797.8 ELR12797.1 - 0.069 13.1 0.0 0.096 12.7 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function C-terminal (DUF3324) ATP_bind_1 PF03029.17 ELR12798.1 - 1.8e-89 299.7 0.2 2e-89 299.5 0.2 1.0 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein CLP1_P PF16575.5 ELR12798.1 - 0.00024 20.9 0.0 0.0039 17.0 0.0 2.2 2 0 0 2 2 2 1 mRNA cleavage and polyadenylation factor CLP1 P-loop AAA_30 PF13604.6 ELR12798.1 - 0.00066 19.5 0.0 0.001 18.8 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 ELR12798.1 - 0.00093 19.8 0.0 0.0023 18.5 0.0 1.6 1 1 0 1 1 1 1 AAA domain Gtr1_RagA PF04670.12 ELR12798.1 - 0.0079 15.6 0.0 2 7.7 0.0 2.2 2 0 0 2 2 2 2 Gtr1/RagA G protein conserved region AAA_29 PF13555.6 ELR12798.1 - 0.037 13.8 0.0 0.066 13.0 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain MeaB PF03308.16 ELR12798.1 - 0.038 13.0 0.0 0.068 12.1 0.0 1.3 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB RsgA_GTPase PF03193.16 ELR12798.1 - 0.066 13.1 0.1 12 5.8 0.0 3.3 2 1 2 4 4 4 0 RsgA GTPase AAA_16 PF13191.6 ELR12798.1 - 0.12 12.7 0.0 0.22 11.9 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain Tubulin PF00091.25 ELR12799.1 - 1.2e-28 100.7 0.0 1.8e-25 90.3 0.0 2.3 1 1 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain F-box-like PF12937.7 ELR12799.1 - 1.2e-05 25.0 0.0 4.5e-05 23.3 0.0 2.0 1 0 0 1 1 1 1 F-box-like DUF5523 PF17661.1 ELR12799.1 - 0.16 11.6 3.1 0.34 10.6 3.1 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5523) Hist_deacetyl PF00850.19 ELR12800.1 - 1.6e-60 205.2 0.0 2.6e-60 204.5 0.0 1.3 1 1 0 1 1 1 1 Histone deacetylase domain Arf PF00025.21 ELR12801.1 - 1.3e-36 125.7 0.0 3.1e-23 82.1 0.0 3.1 3 0 0 3 3 3 3 ADP-ribosylation factor family Roc PF08477.13 ELR12801.1 - 3.6e-10 40.1 0.0 2.6e-05 24.4 0.0 2.3 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase G-alpha PF00503.20 ELR12801.1 - 1.9e-07 30.6 0.0 3.1e-05 23.3 0.0 2.1 1 1 0 2 2 2 2 G-protein alpha subunit Ras PF00071.22 ELR12801.1 - 1.9e-06 27.6 0.0 0.0012 18.5 0.0 2.2 2 0 0 2 2 2 2 Ras family SRPRB PF09439.10 ELR12801.1 - 0.00016 21.2 0.0 0.032 13.7 0.0 2.1 2 0 0 2 2 2 2 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 ELR12801.1 - 0.0018 18.3 0.0 0.0086 16.2 0.0 2.0 1 1 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 ELR12801.1 - 0.096 12.0 0.0 0.8 9.0 0.0 2.0 2 0 0 2 2 2 0 Gtr1/RagA G protein conserved region 6PF2K PF01591.18 ELR12801.1 - 0.28 10.5 0.0 0.42 9.9 0.0 1.2 1 0 0 1 1 1 0 6-phosphofructo-2-kinase HA PF03457.14 ELR12802.1 - 2e-18 66.5 2.9 9.3e-18 64.3 2.9 2.2 1 0 0 1 1 1 1 Helicase associated domain GREB1 PF15782.5 ELR12802.1 - 0.024 11.8 12.5 0.032 11.4 12.5 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer SWIRM-assoc_1 PF16495.5 ELR12802.1 - 0.03 14.3 0.5 0.03 14.3 0.5 3.7 3 1 0 3 3 3 0 SWIRM-associated region 1 DUF4960 PF16324.5 ELR12802.1 - 0.048 13.2 0.2 5.5 6.5 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4960) Phage_RpbA PF10789.9 ELR12802.1 - 5 7.2 6.9 0.96 9.5 0.3 2.7 3 0 0 3 3 3 0 Phage RNA polymerase binding, RpbA ArfGap PF01412.18 ELR12803.1 - 1.7e-39 134.5 0.1 5.1e-38 129.8 0.1 2.5 1 1 0 1 1 1 1 Putative GTPase activating protein for Arf DUF4551 PF15087.6 ELR12803.1 - 1.2 7.9 8.1 1.6 7.5 8.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) zf-C3HC4_2 PF13923.6 ELR12804.1 - 1.9e-09 37.2 13.4 3.3e-09 36.4 13.4 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 ELR12804.1 - 3.7e-08 33.1 12.8 6.4e-08 32.3 12.8 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 ELR12804.1 - 4e-06 27.1 13.0 6.6e-06 26.4 13.0 1.4 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_3 PF13920.6 ELR12804.1 - 1.6e-05 24.7 15.0 2.4e-05 24.1 15.0 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ELR12804.1 - 4.7e-05 23.3 11.1 9.3e-05 22.3 11.1 1.5 1 0 0 1 1 1 1 zinc-RING finger domain RAWUL PF16207.5 ELR12804.1 - 0.00013 22.5 0.1 0.0017 19.0 0.1 2.6 1 1 0 1 1 1 1 RAWUL domain RING finger- and WD40-associated ubiquitin-like zf-RING_UBOX PF13445.6 ELR12804.1 - 0.00099 19.1 11.5 0.0024 17.9 11.5 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-Nse PF11789.8 ELR12804.1 - 0.001 18.8 5.9 0.0022 17.8 5.9 1.4 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_6 PF14835.6 ELR12804.1 - 0.0028 17.5 8.5 0.0049 16.7 8.5 1.3 1 0 0 1 1 1 1 zf-RING of BARD1-type protein DUF3337 PF11816.8 ELR12804.1 - 0.0055 16.6 0.0 0.052 13.4 0.0 2.4 1 1 0 1 1 1 1 Domain of unknown function (DUF3337) zf-C3HC4_4 PF15227.6 ELR12804.1 - 0.026 14.7 11.0 0.051 13.7 11.0 1.5 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING GHMP_kinases_N PF00288.26 ELR12804.1 - 0.069 13.4 0.5 0.069 13.4 0.5 3.1 3 0 0 3 3 3 0 GHMP kinases N terminal domain DUF3449 PF11931.8 ELR12804.1 - 0.091 12.5 1.2 3.2 7.5 0.0 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF3449) TMEM215 PF15746.5 ELR12804.1 - 0.43 10.0 4.9 0.42 10.0 2.5 2.2 2 0 0 2 2 2 0 TMEM215 family zf-C3HC4_5 PF17121.5 ELR12804.1 - 0.49 10.3 10.3 1.4 8.9 10.1 1.9 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING_4 PF14570.6 ELR12804.1 - 1.2 9.0 11.3 2.4 8.0 11.3 1.4 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain GREB1 PF15782.5 ELR12804.1 - 1.6 5.7 15.6 2.9 4.9 15.6 1.3 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer DUF563 PF04577.14 ELR12805.1 - 1.2e-21 77.8 0.0 1.7e-21 77.3 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF563) SR-25 PF10500.9 ELR12805.1 - 0.19 11.4 13.1 1.1 8.9 13.7 1.9 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein Pkinase PF00069.25 ELR12806.1 - 9.6e-72 241.5 0.1 1.3e-71 241.0 0.1 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR12806.1 - 1.1e-35 123.2 0.0 1.5e-35 122.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase PH PF00169.29 ELR12806.1 - 9.1e-20 71.1 0.1 1.8e-19 70.1 0.1 1.5 1 0 0 1 1 1 1 PH domain PH_11 PF15413.6 ELR12806.1 - 1.4e-08 35.1 0.2 3.6e-08 33.8 0.2 1.7 1 0 0 1 1 1 1 Pleckstrin homology domain PH_3 PF14593.6 ELR12806.1 - 1.1e-05 25.5 0.1 5.5e-05 23.2 0.1 2.2 2 0 0 2 2 2 1 PH domain Kinase-like PF14531.6 ELR12806.1 - 7.1e-05 22.3 0.0 0.00035 20.0 0.0 1.9 1 1 1 2 2 2 1 Kinase-like FTA2 PF13095.6 ELR12806.1 - 0.00017 21.3 0.2 0.18 11.4 0.1 2.3 2 0 0 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 Mcp5_PH PF12814.7 ELR12806.1 - 0.00026 21.1 0.3 0.0031 17.6 0.0 2.2 2 0 0 2 2 2 1 Meiotic cell cortex C-terminal pleckstrin homology PH_8 PF15409.6 ELR12806.1 - 0.0056 16.9 0.6 0.011 16.0 0.1 1.8 2 0 0 2 2 2 1 Pleckstrin homology domain PH_9 PF15410.6 ELR12806.1 - 0.017 15.5 0.6 0.095 13.1 0.1 2.2 2 0 0 2 2 2 0 Pleckstrin homology domain APH PF01636.23 ELR12806.1 - 0.022 14.7 0.1 0.052 13.5 0.1 1.8 1 1 0 1 1 1 0 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 ELR12806.1 - 0.058 12.2 0.0 0.097 11.4 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase PH_10 PF15411.6 ELR12806.1 - 0.095 13.0 0.2 0.26 11.6 0.2 1.7 1 0 0 1 1 1 0 Pleckstrin homology domain PolyA_pol PF01743.20 ELR12807.1 - 7.3e-31 107.2 0.0 1.2e-30 106.5 0.0 1.4 1 0 0 1 1 1 1 Poly A polymerase head domain PolyA_pol_RNAbd PF12627.7 ELR12807.1 - 0.00024 20.8 0.0 0.00065 19.4 0.0 1.7 1 0 0 1 1 1 1 Probable RNA and SrmB- binding site of polymerase A tRNA_NucTran2_2 PF13735.6 ELR12807.1 - 0.0026 17.7 0.1 0.0047 16.9 0.1 1.3 1 0 0 1 1 1 1 tRNA nucleotidyltransferase domain 2 putative CH PF00307.31 ELR12808.1 - 0.39 10.9 6.5 0.097 12.9 0.4 3.2 4 0 0 4 4 4 0 Calponin homology (CH) domain Gluconate_2-dh3 PF13618.6 ELR12808.1 - 3.5 7.9 6.1 1.4 9.1 1.6 2.9 2 0 0 2 2 2 0 Gluconate 2-dehydrogenase subunit 3 Frizzled PF01534.17 ELR12810.1 - 5.6e-29 101.2 18.5 7.7e-29 100.8 18.5 1.2 1 0 0 1 1 1 1 Frizzled/Smoothened family membrane region Dicty_CAR PF05462.11 ELR12810.1 - 2.7e-16 59.6 5.2 2.7e-16 59.6 5.2 1.8 2 0 0 2 2 2 1 Slime mold cyclic AMP receptor 7tm_2 PF00002.24 ELR12810.1 - 5e-09 35.8 7.7 5e-09 35.8 7.7 2.0 1 1 1 2 2 2 1 7 transmembrane receptor (Secretin family) Fz PF01392.22 ELR12810.1 - 6.5e-08 33.2 0.5 1.4e-07 32.1 0.5 1.5 1 0 0 1 1 1 1 Fz domain Cytochrom_B561 PF03188.16 ELR12810.1 - 3 8.0 10.8 4 7.6 3.4 3.6 2 1 0 2 2 2 0 Eukaryotic cytochrome b561 EI24 PF07264.11 ELR12811.1 - 3e-10 40.6 15.0 7.1e-10 39.4 15.0 1.6 1 1 0 1 1 1 1 Etoposide-induced protein 2.4 (EI24) FA_desaturase PF00487.24 ELR12811.1 - 2.9 7.7 9.6 6.4 6.5 1.3 2.3 2 0 0 2 2 2 0 Fatty acid desaturase DUF1616 PF07760.11 ELR12811.1 - 3 7.2 5.9 57 2.9 6.1 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1616) Ank_2 PF12796.7 ELR12812.1 - 1.1e-51 173.3 3.8 2.3e-18 66.6 0.3 5.3 1 1 4 5 5 5 4 Ankyrin repeats (3 copies) Ank PF00023.30 ELR12812.1 - 3.8e-46 153.6 1.3 3.7e-06 27.1 0.1 8.2 8 0 0 8 8 8 7 Ankyrin repeat Ank_4 PF13637.6 ELR12812.1 - 7.5e-42 141.2 4.6 6.6e-11 42.5 0.1 7.4 3 1 6 9 9 9 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 ELR12812.1 - 1.1e-39 129.8 0.2 1.1e-05 25.4 0.0 7.8 7 0 0 7 7 7 7 Ankyrin repeat Ank_5 PF13857.6 ELR12812.1 - 4.3e-30 103.4 4.7 1.7e-08 34.6 0.1 6.4 1 1 5 6 6 6 6 Ankyrin repeats (many copies) F-box-like PF12937.7 ELR12812.1 - 1.2e-07 31.4 1.7 2.2e-07 30.7 0.1 2.2 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 ELR12812.1 - 1.6e-07 31.0 1.9 1.7e-06 27.7 0.1 2.6 2 0 0 2 2 2 1 F-box domain Mhr1 PF12829.7 ELR12812.1 - 0.014 15.4 0.0 0.052 13.6 0.0 1.9 1 0 0 1 1 1 0 Transcriptional regulation of mitochondrial recombination NPR1_interact PF15699.5 ELR12812.1 - 0.046 14.3 7.0 0.12 13.0 7.0 1.6 1 0 0 1 1 1 0 NPR1 interacting CDC45 PF02724.14 ELR12812.1 - 0.087 11.1 2.1 0.11 10.7 2.1 1.2 1 0 0 1 1 1 0 CDC45-like protein Prenylcys_lyase PF07156.14 ELR12812.1 - 0.16 11.0 0.3 0.82 8.7 0.1 2.0 2 0 0 2 2 2 0 Prenylcysteine lyase Ras PF00071.22 ELR12813.1 - 1.6e-57 193.7 0.0 1.8e-57 193.5 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR12813.1 - 5.7e-21 75.0 0.0 8.3e-21 74.4 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR12813.1 - 1.6e-10 40.7 0.0 1.8e-10 40.5 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 ELR12813.1 - 2.9e-05 23.7 0.3 0.00018 21.1 0.0 2.0 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 ELR12813.1 - 6.2e-05 23.0 0.2 0.35 10.8 0.0 2.3 1 1 0 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 ELR12813.1 - 0.00022 21.3 0.0 0.00035 20.6 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase ATP_bind_1 PF03029.17 ELR12813.1 - 0.0026 17.6 0.2 0.33 10.7 0.0 2.1 1 1 1 2 2 2 1 Conserved hypothetical ATP binding protein Septin PF00735.18 ELR12813.1 - 0.039 13.2 0.3 0.46 9.7 0.0 2.3 2 0 0 2 2 2 0 Septin G-alpha PF00503.20 ELR12813.1 - 0.091 11.9 0.0 9.5 5.3 0.0 2.1 1 1 0 2 2 2 0 G-protein alpha subunit AAA_28 PF13521.6 ELR12813.1 - 0.093 13.0 0.1 0.21 11.8 0.0 2.0 1 1 0 1 1 1 0 AAA domain FeoB_N PF02421.18 ELR12813.1 - 0.099 12.2 0.0 4 7.0 0.0 2.2 2 0 0 2 2 2 0 Ferrous iron transport protein B NB-ARC PF00931.22 ELR12813.1 - 0.11 11.7 0.0 0.16 11.1 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain AAA_22 PF13401.6 ELR12813.1 - 0.11 12.7 0.6 3.3 8.0 0.3 2.4 2 1 0 2 2 2 0 AAA domain ParA PF10609.9 ELR12813.1 - 0.2 11.1 0.0 0.43 10.0 0.0 1.5 2 0 0 2 2 2 0 NUBPL iron-transfer P-loop NTPase SKG6 PF08693.10 ELR12814.1 - 0.76 9.2 5.3 2.7 7.5 5.3 1.9 1 0 0 1 1 1 0 Transmembrane alpha-helix domain Abhydrolase_2 PF02230.16 ELR12815.1 - 6.7e-21 75.1 0.0 1.3e-20 74.1 0.0 1.4 1 1 0 1 1 1 1 Phospholipase/Carboxylesterase Abhydrolase_6 PF12697.7 ELR12815.1 - 1.9e-06 28.7 0.5 3.1e-06 28.0 0.5 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 ELR12815.1 - 2.1e-06 27.2 0.1 0.039 13.2 0.0 3.1 2 1 1 3 3 3 2 Serine aminopeptidase, S33 FSH1 PF03959.13 ELR12815.1 - 1.1e-05 25.2 0.0 1.6e-05 24.7 0.0 1.3 1 0 0 1 1 1 1 Serine hydrolase (FSH1) Peptidase_S9 PF00326.21 ELR12815.1 - 0.0015 18.0 0.0 0.013 15.0 0.0 2.1 1 1 0 2 2 2 1 Prolyl oligopeptidase family Esterase_phd PF10503.9 ELR12815.1 - 0.0034 16.9 0.1 1.7 8.1 0.0 2.3 1 1 1 2 2 2 2 Esterase PHB depolymerase LIP PF03583.14 ELR12815.1 - 0.031 13.6 0.0 0.39 10.0 0.0 2.0 1 1 0 2 2 2 0 Secretory lipase Abhydrolase_3 PF07859.13 ELR12815.1 - 0.045 13.6 0.0 0.056 13.3 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold Ser_hydrolase PF06821.13 ELR12815.1 - 0.063 13.1 0.0 0.087 12.7 0.0 1.2 1 0 0 1 1 1 0 Serine hydrolase DZR PF12773.7 ELR12815.1 - 0.1 12.6 1.3 0.17 11.9 1.3 1.3 1 0 0 1 1 1 0 Double zinc ribbon DLH PF01738.18 ELR12815.1 - 0.13 11.8 0.0 0.19 11.3 0.0 1.2 1 0 0 1 1 1 0 Dienelactone hydrolase family EHN PF06441.12 ELR12817.1 - 7.5e-36 122.8 1.0 1.4e-35 121.9 1.0 1.5 1 0 0 1 1 1 1 Epoxide hydrolase N terminus Abhydrolase_1 PF00561.20 ELR12817.1 - 6.7e-14 52.1 0.1 1.2e-13 51.4 0.1 1.5 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 ELR12817.1 - 8.7e-09 36.3 2.0 2.8e-08 34.6 2.0 1.9 1 1 0 1 1 1 1 Alpha/beta hydrolase family RCC1 PF00415.18 ELR12818.1 - 5e-61 203.1 8.3 2.8e-13 50.3 0.0 7.8 7 1 0 7 7 7 7 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 ELR12818.1 - 3.9e-39 131.7 21.8 6.8e-09 35.3 0.0 7.3 7 0 0 7 7 7 6 Regulator of chromosome condensation (RCC1) repeat F-box-like PF12937.7 ELR12818.1 - 0.004 17.0 0.8 0.0072 16.2 0.8 1.4 1 0 0 1 1 1 1 F-box-like Kelch_4 PF13418.6 ELR12818.1 - 0.086 12.9 0.6 45 4.1 0.0 3.7 3 0 0 3 3 3 0 Galactose oxidase, central domain PQQ_3 PF13570.6 ELR12818.1 - 0.69 10.5 2.4 34 5.1 0.0 3.5 3 0 0 3 3 3 0 PQQ-like domain Lebercilin PF15619.6 ELR12822.1 - 0.0085 15.8 0.5 0.016 14.9 0.2 1.5 1 1 0 1 1 1 1 Ciliary protein causing Leber congenital amaurosis disease YojJ PF10372.9 ELR12822.1 - 1.7 8.8 5.9 9.9 6.3 0.1 2.7 3 0 0 3 3 3 0 Bacterial membrane-spanning protein N-terminus DUF4611 PF15387.6 ELR12823.1 - 0.15 12.3 1.5 9 6.6 0.3 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4611) Glyco_hydro_16 PF00722.21 ELR12824.1 - 1.2e-06 28.2 0.8 3.6e-06 26.6 0.1 2.3 2 1 0 2 2 2 1 Glycosyl hydrolases family 16 RhoGEF PF00621.20 ELR12825.1 - 1.8e-51 174.9 0.5 3e-51 174.3 0.5 1.3 1 0 0 1 1 1 1 RhoGEF domain PH_13 PF16652.5 ELR12825.1 - 0.0087 15.9 1.2 0.023 14.5 0.0 2.2 3 0 0 3 3 3 1 Pleckstrin homology domain PH_10 PF15411.6 ELR12825.1 - 0.074 13.3 0.2 0.26 11.5 0.0 2.0 2 0 0 2 2 2 0 Pleckstrin homology domain DUF4746 PF15928.5 ELR12825.1 - 1 8.7 4.0 1.8 7.9 4.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) SRP54 PF00448.22 ELR12826.1 - 8.3e-53 178.9 0.2 2e-52 177.7 0.2 1.6 1 1 0 1 1 1 1 SRP54-type protein, GTPase domain SRP-alpha_N PF04086.13 ELR12826.1 - 3.2e-50 171.7 6.7 4.2e-50 171.3 6.7 1.1 1 0 0 1 1 1 1 Signal recognition particle, alpha subunit, N-terminal SRP54_N PF02881.19 ELR12826.1 - 7.5e-06 26.1 0.3 6.6e-05 23.1 0.0 2.7 2 0 0 2 2 2 1 SRP54-type protein, helical bundle domain MeaB PF03308.16 ELR12826.1 - 9.6e-05 21.5 0.0 0.00027 20.0 0.0 1.7 1 1 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB MMR_HSR1 PF01926.23 ELR12826.1 - 0.00073 19.6 0.0 0.0028 17.7 0.0 1.9 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA PF00004.29 ELR12826.1 - 0.00077 19.9 0.1 0.13 12.7 0.0 2.8 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 ELR12826.1 - 0.0032 17.9 0.0 0.016 15.6 0.0 2.2 1 1 1 2 2 2 1 AAA ATPase domain NTPase_1 PF03266.15 ELR12826.1 - 0.0054 16.7 0.4 0.64 9.9 0.1 2.8 3 0 0 3 3 3 1 NTPase APS_kinase PF01583.20 ELR12826.1 - 0.022 14.6 0.1 1 9.2 0.0 2.9 3 0 0 3 3 3 0 Adenylylsulphate kinase CLP1_P PF16575.5 ELR12826.1 - 0.067 13.0 0.2 13 5.6 0.2 2.3 2 0 0 2 2 2 0 mRNA cleavage and polyadenylation factor CLP1 P-loop Fer4_NifH PF00142.18 ELR12826.1 - 0.069 12.6 0.0 0.16 11.4 0.0 1.6 1 0 0 1 1 1 0 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family CbiA PF01656.23 ELR12826.1 - 0.14 12.2 0.3 1.1 9.3 0.2 2.5 2 1 0 2 2 2 0 CobQ/CobB/MinD/ParA nucleotide binding domain RNA_pol_Rpb6 PF01192.22 ELR12827.1 - 6.7e-15 54.8 0.5 8.7e-15 54.4 0.5 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb6 LMBR1 PF04791.16 ELR12828.1 - 2.3e-20 73.0 0.3 2.3e-20 73.0 0.3 2.5 2 1 1 3 3 3 2 LMBR1-like membrane protein FtsH_ext PF06480.15 ELR12828.1 - 0.55 10.6 0.0 0.55 10.6 0.0 4.1 6 0 0 6 6 6 0 FtsH Extracellular GWT1 PF06423.12 ELR12828.1 - 2.9 8.0 11.2 0.12 12.5 0.3 3.2 2 2 0 2 2 2 0 GWT1 ADP_PFK_GK PF04587.15 ELR12829.1 - 3.1e-103 345.6 0.0 4e-103 345.2 0.0 1.0 1 0 0 1 1 1 1 ADP-specific Phosphofructokinase/Glucokinase conserved region PfkB PF00294.24 ELR12829.1 - 0.00046 19.6 0.0 0.00085 18.7 0.0 1.5 1 0 0 1 1 1 1 pfkB family carbohydrate kinase DUF4291 PF14124.6 ELR12830.1 - 2.3e-44 151.5 0.0 5.6e-42 143.6 0.0 2.2 1 1 0 1 1 1 1 Domain of unknown function (DUF4291) KHA PF11834.8 ELR12830.1 - 0.12 12.5 0.0 0.21 11.7 0.0 1.4 1 0 0 1 1 1 0 KHA, dimerisation domain of potassium ion channel FliX PF10768.9 ELR12831.1 - 0.1 13.1 0.0 0.16 12.5 0.0 1.3 1 0 0 1 1 1 0 Class II flagellar assembly regulator Amidohydro_1 PF01979.20 ELR12832.1 - 7.8e-44 150.4 0.0 1.6e-43 149.3 0.0 1.4 1 1 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 ELR12832.1 - 5.3e-15 55.9 0.0 1.2e-10 41.5 0.0 2.5 3 0 0 3 3 3 2 Amidohydrolase family Mpv17_PMP22 PF04117.12 ELR12833.1 - 1.9e-20 72.9 1.7 1.9e-20 72.9 1.7 1.9 2 0 0 2 2 2 1 Mpv17 / PMP22 family Pox_E8 PF03394.13 ELR12833.1 - 0.064 12.8 0.8 0.1 12.1 0.0 1.7 2 0 0 2 2 2 0 Poxvirus E8 protein Ras PF00071.22 ELR12834.1 - 5.2e-46 156.2 0.0 6.8e-46 155.8 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR12834.1 - 5.2e-29 100.9 0.1 1.1e-28 99.9 0.0 1.5 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR12834.1 - 1.7e-16 60.2 0.0 2.6e-16 59.6 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 ELR12834.1 - 6.6e-06 25.8 0.0 0.00045 19.8 0.0 2.6 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 ELR12834.1 - 4.2e-05 23.6 0.1 9.6e-05 22.4 0.0 1.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase SRPRB PF09439.10 ELR12834.1 - 0.0026 17.2 0.1 0.0081 15.6 0.0 1.7 2 0 0 2 2 2 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 ELR12834.1 - 0.0055 16.1 0.0 0.0065 15.8 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 ELR12834.1 - 0.036 14.0 0.0 1 9.2 0.0 2.5 2 1 1 3 3 3 0 RsgA GTPase FeoB_N PF02421.18 ELR12834.1 - 0.063 12.8 0.0 0.19 11.2 0.0 1.8 1 1 0 1 1 1 0 Ferrous iron transport protein B BolA PF01722.18 ELR12834.1 - 0.068 13.5 0.0 0.15 12.4 0.0 1.5 1 0 0 1 1 1 0 BolA-like protein AAA_16 PF13191.6 ELR12834.1 - 0.13 12.6 0.5 0.79 10.1 0.5 2.0 1 1 0 1 1 1 0 AAA ATPase domain AAA_24 PF13479.6 ELR12834.1 - 0.14 11.9 0.0 0.24 11.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain tRNA-synt_1 PF00133.22 ELR12836.1 - 1.1e-183 611.8 0.0 1.6e-183 611.3 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 ELR12836.1 - 3.7e-27 95.2 0.0 6.4e-27 94.4 0.0 1.4 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.11 ELR12836.1 - 1.9e-21 76.3 0.0 2.3e-14 53.0 0.0 3.3 3 0 0 3 3 3 3 tRNA synthetases class I (M) tRNA-synt_1_2 PF13603.6 ELR12836.1 - 3.4e-05 23.5 0.0 6.3e-05 22.6 0.0 1.4 1 0 0 1 1 1 1 Leucyl-tRNA synthetase, Domain 2 tRNA-synt_1e PF01406.19 ELR12836.1 - 0.00094 18.6 0.0 0.35 10.1 0.0 2.3 2 0 0 2 2 2 2 tRNA synthetases class I (C) catalytic domain zf-FPG_IleRS PF06827.14 ELR12836.1 - 4.8 7.1 11.0 41 4.1 11.0 2.2 1 1 0 1 1 1 0 Zinc finger found in FPG and IleRS Raptor_N PF14538.6 ELR12837.1 - 2e-59 199.7 0.0 3.8e-59 198.8 0.0 1.5 1 0 0 1 1 1 1 Raptor N-terminal CASPase like domain HEAT PF02985.22 ELR12837.1 - 5.1e-11 41.8 4.5 0.0024 18.0 0.0 6.0 5 0 0 5 5 5 3 HEAT repeat WD40 PF00400.32 ELR12837.1 - 9.8e-11 42.0 7.4 1.5 9.8 0.0 7.6 7 0 0 7 7 7 4 WD domain, G-beta repeat HEAT_2 PF13646.6 ELR12837.1 - 2.3e-06 27.9 2.5 0.00049 20.4 0.1 3.6 2 1 2 4 4 4 3 HEAT repeats Cnd1 PF12717.7 ELR12837.1 - 0.00075 19.6 0.0 0.073 13.1 0.0 2.9 2 1 1 3 3 3 1 non-SMC mitotic condensation complex subunit 1 ANAPC4_WD40 PF12894.7 ELR12837.1 - 0.017 15.4 0.0 2.5 8.4 0.0 3.5 1 1 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain HEAT_EZ PF13513.6 ELR12837.1 - 0.023 15.2 1.7 0.14 12.7 0.1 3.1 3 0 0 3 3 3 0 HEAT-like repeat Zn_clus PF00172.18 ELR12838.1 - 1.5e-06 28.2 8.8 2.5e-06 27.5 8.8 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain PAS_9 PF13426.7 ELR12838.1 - 5.6e-05 23.3 0.0 0.00017 21.8 0.0 1.7 1 0 0 1 1 1 1 PAS domain PAS_4 PF08448.10 ELR12838.1 - 0.061 13.6 0.0 0.13 12.5 0.0 1.5 1 0 0 1 1 1 0 PAS fold LRR_8 PF13855.6 ELR12839.1 - 3.6e-11 42.6 14.9 1.8e-08 34.0 7.1 3.3 2 1 1 3 3 3 2 Leucine rich repeat DSPc PF00782.20 ELR12839.1 - 1.8e-09 37.5 0.2 2.3e-08 33.9 0.1 2.7 2 1 0 2 2 2 1 Dual specificity phosphatase, catalytic domain LRR_4 PF12799.7 ELR12839.1 - 2.7e-09 37.2 16.8 3.4e-05 24.1 2.4 3.4 1 1 3 4 4 4 4 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 ELR12839.1 - 6.8e-05 22.9 12.6 2.2 9.1 0.1 5.3 4 1 0 4 4 4 3 Leucine Rich Repeat PPARgamma_N PF12577.8 ELR12839.1 - 0.12 13.1 0.5 1.6 9.4 0.4 2.8 1 1 0 1 1 1 0 PPAR gamma N-terminal region LRR_6 PF13516.6 ELR12839.1 - 0.16 12.1 12.7 6.1 7.2 0.1 4.5 4 0 0 4 4 4 0 Leucine Rich repeat NOA36 PF06524.12 ELR12839.1 - 0.42 9.9 6.5 1 8.6 6.5 1.5 1 1 0 1 1 1 0 NOA36 protein PQQ_2 PF13360.6 ELR12840.1 - 4.3e-12 46.1 1.4 1.5e-06 27.9 0.1 3.5 2 1 1 3 3 3 2 PQQ-like domain PQQ PF01011.21 ELR12840.1 - 5.1e-05 23.0 0.7 0.0013 18.6 0.1 3.4 3 0 0 3 3 3 1 PQQ enzyme repeat RRM_1 PF00076.22 ELR12841.1 - 1.5e-55 184.9 0.0 3.1e-25 87.8 0.0 3.3 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RBM39linker PF15519.6 ELR12841.1 - 1.5e-13 51.7 7.6 6.8e-06 27.1 0.0 3.6 4 0 0 4 4 4 2 linker between RRM2 and RRM3 domains in RBM39 protein RRM_occluded PF16842.5 ELR12841.1 - 6.2e-08 32.4 0.0 0.0027 17.5 0.0 3.2 3 0 0 3 3 3 2 Occluded RNA-recognition motif RRM_5 PF13893.6 ELR12841.1 - 8.4e-06 25.4 0.0 0.022 14.3 0.0 2.6 2 1 1 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 ELR12841.1 - 2e-05 24.5 0.0 0.0079 16.2 0.0 3.1 3 0 0 3 3 3 1 Nup53/35/40-type RNA recognition motif Nup35_RRM PF05172.13 ELR12841.1 - 0.00033 20.6 0.0 1.5 8.8 0.0 3.4 3 1 0 3 3 3 1 Nup53/35/40-type RNA recognition motif RRM_7 PF16367.5 ELR12841.1 - 0.00039 20.5 0.0 0.9 9.7 0.0 3.6 3 1 0 3 3 3 1 RNA recognition motif RRM_9 PF18444.1 ELR12841.1 - 0.00077 19.3 0.1 0.089 12.7 0.0 2.8 3 0 0 3 3 3 1 RNA recognition motif RRM_3 PF08777.11 ELR12841.1 - 0.0013 18.7 0.0 0.34 11.0 0.0 2.7 2 0 0 2 2 2 1 RNA binding motif RRM_Rrp7 PF17799.1 ELR12841.1 - 0.002 18.0 0.0 0.094 12.5 0.0 2.3 1 1 1 2 2 2 1 Rrp7 RRM-like N-terminal domain DbpA PF03880.15 ELR12841.1 - 0.019 14.9 0.0 11 6.1 0.0 3.2 3 0 0 3 3 3 0 DbpA RNA binding domain RSRP PF17069.5 ELR12841.1 - 0.12 11.9 54.1 0.22 11.1 54.1 1.3 1 0 0 1 1 1 0 Arginine/Serine-Rich protein 1 LRR_6 PF13516.6 ELR12842.1 - 7.8e-10 38.0 0.1 0.0085 16.1 0.0 4.6 4 0 0 4 4 4 3 Leucine Rich repeat LRR_4 PF12799.7 ELR12842.1 - 0.0013 19.1 0.0 2.5 8.7 0.0 3.2 2 0 0 2 2 2 2 Leucine Rich repeats (2 copies) ABC_tran_CTD PF16326.5 ELR12842.1 - 0.031 14.5 1.1 0.099 12.9 1.1 2.0 1 0 0 1 1 1 0 ABC transporter C-terminal domain LRR_8 PF13855.6 ELR12842.1 - 0.21 11.4 5.2 5.9 6.7 0.0 3.7 4 1 0 4 4 4 0 Leucine rich repeat Endonuc_Holl PF10107.9 ELR12842.1 - 0.3 10.9 3.5 0.23 11.3 1.2 1.9 1 1 1 2 2 2 0 Endonuclease related to archaeal Holliday junction resolvase Ax_dynein_light PF10211.9 ELR12842.1 - 0.49 10.3 7.5 0.15 12.0 3.8 1.9 1 1 1 2 2 2 0 Axonemal dynein light chain V_ATPase_I PF01496.19 ELR12842.1 - 1.6 6.5 4.7 2.1 6.2 4.7 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family BST2 PF16716.5 ELR12842.1 - 9.2 6.9 9.5 0.9 10.2 1.0 3.3 2 1 2 4 4 4 0 Bone marrow stromal antigen 2 LRR_6 PF13516.6 ELR12843.1 - 1.9e-39 130.4 38.4 5.1e-05 23.0 0.1 11.7 12 0 0 12 12 12 11 Leucine Rich repeat LRR_1 PF00560.33 ELR12843.1 - 1.1e-09 37.4 1.0 0.033 14.7 0.0 7.7 9 1 0 9 9 9 1 Leucine Rich Repeat LRR_4 PF12799.7 ELR12843.1 - 8.6e-08 32.4 14.5 1.7 9.2 0.1 7.7 5 2 3 8 8 8 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 ELR12843.1 - 0.001 18.8 17.1 0.58 10.0 0.1 7.4 5 3 1 6 6 6 2 Leucine rich repeat LRR_12 PF18837.1 ELR12843.1 - 0.0014 18.2 0.1 4.8 6.9 0.0 4.0 4 0 0 4 4 4 1 Leucine-rich repeat DUF2202 PF09968.9 ELR12843.1 - 0.14 12.0 0.3 7.3 6.4 0.1 2.8 3 1 1 4 4 4 0 Uncharacterized protein domain (DUF2202) 5_3_exonuc PF01367.20 ELR12843.1 - 0.23 12.1 1.7 1.5 9.4 0.2 2.4 2 0 0 2 2 2 0 5'-3' exonuclease, C-terminal SAM fold WD40 PF00400.32 ELR12844.1 - 2.1e-43 145.4 4.9 2.5e-05 24.9 0.0 7.4 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ELR12844.1 - 2.7e-09 37.2 2.6 0.048 14.0 0.0 5.5 2 2 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ELR12844.1 - 4e-05 22.5 0.7 0.13 10.8 0.0 3.1 2 1 1 3 3 3 2 Nucleoporin Nup120/160 PALB2_WD40 PF16756.5 ELR12844.1 - 0.003 16.5 0.4 2.3 7.0 0.0 3.7 3 1 0 4 4 4 1 Partner and localizer of BRCA2 WD40 domain WD40_like PF17005.5 ELR12844.1 - 0.14 11.4 0.0 11 5.3 0.0 3.2 3 1 1 4 4 4 0 WD40-like domain Zip PF02535.22 ELR12845.1 - 7.1e-50 170.1 7.0 9.5e-50 169.7 7.0 1.1 1 0 0 1 1 1 1 ZIP Zinc transporter DUF4212 PF13937.6 ELR12845.1 - 0.065 13.6 0.9 0.28 11.6 0.9 2.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4212) Phage_holin_3_6 PF07332.11 ELR12845.1 - 0.2 11.7 0.0 0.2 11.7 0.0 2.8 2 1 1 3 3 3 0 Putative Actinobacterial Holin-X, holin superfamily III DUF4203 PF13886.6 ELR12845.1 - 4.3 7.0 16.6 2.1 8.0 0.5 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF4203) PBD PF00786.28 ELR12846.1 - 2.3e-15 56.7 0.1 2.3e-15 56.7 0.1 2.2 2 0 0 2 2 2 1 P21-Rho-binding domain SMN PF06003.12 ELR12846.1 - 6.9e-07 28.8 0.0 6.9e-07 28.8 0.0 2.8 3 0 0 3 3 3 1 Survival motor neuron protein (SMN) TUDOR PF00567.24 ELR12846.1 - 0.027 14.5 0.0 0.056 13.5 0.0 1.5 1 0 0 1 1 1 0 Tudor domain Phage_TAC_4 PF08748.11 ELR12846.1 - 0.03 14.6 0.6 0.066 13.5 0.4 1.7 2 0 0 2 2 2 0 Phage tail assembly chaperone FKBP_N PF01346.18 ELR12846.1 - 0.21 12.6 6.4 7.1 7.7 5.6 2.6 2 0 0 2 2 2 0 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase SR-25 PF10500.9 ELR12846.1 - 0.35 10.4 8.4 0.53 9.9 8.4 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Peptidase_S49_N PF08496.10 ELR12846.1 - 4.2 7.4 8.8 7.9 6.5 8.8 1.4 1 0 0 1 1 1 0 Peptidase family S49 N-terminal Peptidase_S49_N PF08496.10 ELR12848.1 - 1.8 8.6 4.1 3.6 7.6 4.1 1.5 1 1 0 1 1 1 0 Peptidase family S49 N-terminal START PF01852.19 ELR12849.1 - 5.1e-19 68.5 0.0 6.5e-19 68.2 0.0 1.1 1 0 0 1 1 1 1 START domain EF-hand_6 PF13405.6 ELR12850.1 - 1.3e-16 59.0 2.8 3.2e-07 29.7 0.1 3.6 2 1 2 4 4 4 2 EF-hand domain EF-hand_7 PF13499.6 ELR12850.1 - 3.4e-16 59.4 0.2 3.4e-08 33.8 0.2 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 ELR12850.1 - 9e-16 56.2 8.3 3.1e-07 29.5 0.5 4.1 5 0 0 5 5 5 2 EF hand EF-hand_5 PF13202.6 ELR12850.1 - 8.1e-12 44.1 9.0 5.1e-06 25.7 0.1 3.2 4 0 0 4 4 4 2 EF hand EF-hand_9 PF14658.6 ELR12850.1 - 9.1e-08 32.3 0.0 0.0029 17.9 0.0 2.1 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.6 ELR12850.1 - 8.3e-07 28.8 5.3 2.8e-05 23.9 0.1 3.3 2 2 2 4 4 4 2 EF-hand domain pair EFhand_Ca_insen PF08726.10 ELR12850.1 - 0.004 17.2 0.2 0.032 14.3 0.0 2.3 2 1 0 2 2 2 1 Ca2+ insensitive EF hand Toprim_2 PF13155.6 ELR12850.1 - 0.01 16.3 0.1 0.31 11.5 0.0 2.1 1 1 1 2 2 2 1 Toprim-like UPF0154 PF03672.13 ELR12850.1 - 0.018 15.0 0.1 4 7.5 0.0 2.3 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0154) Caleosin PF05042.13 ELR12850.1 - 0.026 14.5 0.1 0.95 9.4 0.0 2.4 2 1 1 3 3 3 0 Caleosin related protein Dockerin_1 PF00404.18 ELR12850.1 - 0.028 14.6 0.3 1.4 9.2 0.0 2.6 2 1 1 3 3 3 0 Dockerin type I domain EF-hand_11 PF08976.11 ELR12850.1 - 0.096 13.6 0.1 0.24 12.3 0.0 1.6 2 0 0 2 2 2 0 EF-hand domain EF-hand_14 PF17959.1 ELR12850.1 - 0.15 12.4 0.1 0.97 9.8 0.0 2.0 2 0 0 2 2 2 0 EF-hand domain DUF2666 PF10869.8 ELR12850.1 - 0.16 12.2 0.3 8.7 6.6 0.1 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF2666) DUF1963 PF09234.10 ELR12851.1 - 3e-07 31.1 1.2 9.8e-07 29.4 0.0 2.3 2 1 0 2 2 2 1 Domain of unknown function (DUF1963) LcnG-beta PF11632.8 ELR12851.1 - 0.19 11.7 1.2 14 5.7 0.0 2.5 2 0 0 2 2 2 0 Lactococcin G-beta C2 PF00168.30 ELR12852.1 - 6e-13 49.0 0.0 1.7e-11 44.3 0.0 2.1 2 0 0 2 2 2 2 C2 domain V-SNARE_C PF12352.8 ELR12853.1 - 0.0044 17.3 2.1 0.16 12.3 0.1 3.0 3 0 0 3 3 3 1 Snare region anchored in the vesicle membrane C-terminus DUF5089 PF17002.5 ELR12853.1 - 0.014 15.3 10.4 0.033 14.1 10.4 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF5089) NPV_P10 PF05531.12 ELR12853.1 - 0.028 14.9 0.5 2.7 8.5 0.0 2.4 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein DUF2802 PF10975.8 ELR12853.1 - 0.031 14.4 0.5 0.78 9.9 0.0 3.0 2 2 0 2 2 2 0 Protein of unknown function (DUF2802) LodA_N PF17990.1 ELR12853.1 - 0.041 13.8 0.3 0.044 13.7 0.3 1.2 1 0 0 1 1 1 0 L-Lysine epsilon oxidase N-terminal Neur_chan_memb PF02932.16 ELR12853.1 - 0.46 10.5 2.7 0.56 10.2 2.7 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region EBP PF05241.12 ELR12854.1 - 0.076 12.5 7.4 0.092 12.2 7.4 1.1 1 0 0 1 1 1 0 Emopamil binding protein PMP1_2 PF08114.11 ELR12854.1 - 0.37 10.6 4.0 4.4 7.1 0.4 3.0 3 0 0 3 3 3 0 ATPase proteolipid family EF-hand_1 PF00036.32 ELR12855.1 - 2.6e-18 64.1 2.4 7.9e-06 25.1 0.0 4.8 4 1 1 5 5 5 4 EF hand EF-hand_6 PF13405.6 ELR12855.1 - 1.1e-17 62.4 0.2 5.5e-05 22.8 0.0 4.7 4 1 1 5 5 5 3 EF-hand domain EF-hand_7 PF13499.6 ELR12855.1 - 1.5e-16 60.6 0.3 1.3e-07 31.9 0.2 3.1 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 ELR12855.1 - 1.1e-15 56.3 3.6 1.4e-06 27.5 0.0 4.5 4 0 0 4 4 4 3 EF hand EF-hand_8 PF13833.6 ELR12855.1 - 1.7e-08 34.2 4.2 0.00028 20.7 0.1 4.2 2 1 0 3 3 3 3 EF-hand domain pair EF-hand_4 PF12763.7 ELR12855.1 - 0.0039 17.1 0.4 0.044 13.7 0.0 2.5 1 1 2 3 3 3 1 Cytoskeletal-regulatory complex EF hand DNA_ligase_A_N PF04675.14 ELR12855.1 - 0.078 13.3 0.0 0.094 13.0 0.0 1.2 1 0 0 1 1 1 0 DNA ligase N terminus SPARC_Ca_bdg PF10591.9 ELR12855.1 - 0.079 13.3 0.0 1.5 9.2 0.0 2.4 2 1 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region Cytochrom_B561 PF03188.16 ELR12856.1 - 4e-18 65.9 6.0 4e-18 65.9 6.0 2.0 2 0 0 2 2 2 1 Eukaryotic cytochrome b561 SPC25 PF06703.11 ELR12856.1 - 0.011 15.6 0.2 0.022 14.5 0.2 1.6 1 0 0 1 1 1 0 Microsomal signal peptidase 25 kDa subunit (SPC25) DUF4079 PF13301.6 ELR12856.1 - 0.022 14.9 9.8 0.065 13.4 9.8 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF4079) DUF3995 PF13160.6 ELR12856.1 - 0.22 11.9 0.2 0.22 11.9 0.2 3.0 1 1 2 3 3 3 0 Protein of unknown function (DUF3995) DUF2427 PF10348.9 ELR12856.1 - 0.5 10.2 5.1 9.1 6.1 0.2 3.1 2 2 1 3 3 3 0 Domain of unknown function (DUF2427) Na_H_Exchanger PF00999.21 ELR12860.1 - 3.7e-70 236.7 43.6 4.5e-70 236.4 43.6 1.1 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family Afaf PF15339.6 ELR12860.1 - 0.089 12.5 0.8 0.26 11.0 0.8 1.7 1 0 0 1 1 1 0 Acrosome formation-associated factor Tim17 PF02466.19 ELR12860.1 - 0.72 10.2 3.9 4.3 7.8 0.3 2.9 2 1 0 2 2 2 0 Tim17/Tim22/Tim23/Pmp24 family TMEM171 PF15471.6 ELR12861.1 - 0.36 9.8 0.7 0.49 9.3 0.3 1.4 1 1 1 2 2 2 0 Transmembrane protein family 171 baeRF_family12 PF18856.1 ELR12862.1 - 0.065 13.8 0.1 0.11 13.0 0.1 1.3 1 0 0 1 1 1 0 Bacterial archaeo-eukaryotic release factor family 12 DHHC PF01529.20 ELR12863.1 - 2.2e-16 60.2 17.9 5.9e-13 49.1 3.1 3.1 3 0 0 3 3 3 2 DHHC palmitoyltransferase Mem_trans PF03547.18 ELR12864.1 - 4.2e-34 117.6 21.0 8e-19 67.3 8.0 3.0 3 0 0 3 3 3 3 Membrane transport protein Acetyltransf_1 PF00583.25 ELR12865.1 - 1.2e-08 35.2 0.0 1.3e-08 35.0 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 ELR12865.1 - 5.1e-07 30.0 0.0 7.5e-07 29.5 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 ELR12865.1 - 1e-06 28.8 0.0 1.7e-06 28.2 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 ELR12865.1 - 4.4e-06 26.6 0.0 6.5e-06 26.1 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 ELR12865.1 - 0.00042 20.2 0.0 0.00078 19.4 0.0 1.4 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_CG PF14542.6 ELR12865.1 - 0.00044 20.3 0.0 0.00079 19.5 0.0 1.3 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase Arf PF00025.21 ELR12866.1 - 1.5e-59 200.4 0.0 2.8e-58 196.2 0.0 2.2 1 1 0 1 1 1 1 ADP-ribosylation factor family RCC1 PF00415.18 ELR12866.1 - 9.1e-47 157.5 24.9 3.4e-13 50.0 0.7 6.3 5 1 1 6 6 5 5 Regulator of chromosome condensation (RCC1) repeat Kelch_3 PF13415.6 ELR12866.1 - 2.8e-29 100.8 18.4 2.1e-06 27.9 0.6 6.9 5 1 1 6 6 6 5 Galactose oxidase, central domain Kelch_4 PF13418.6 ELR12866.1 - 1e-21 76.7 23.7 1.6e-06 28.0 0.3 7.6 8 0 0 8 8 8 4 Galactose oxidase, central domain Kelch_1 PF01344.25 ELR12866.1 - 4.2e-21 74.3 21.4 1.3e-09 37.5 1.9 6.7 8 0 0 8 8 8 3 Kelch motif Kelch_5 PF13854.6 ELR12866.1 - 3.1e-16 58.9 15.2 4.2e-05 23.4 0.0 6.7 7 0 0 7 7 7 3 Kelch motif RCC1_2 PF13540.6 ELR12866.1 - 5.3e-13 48.4 28.0 1.3e-07 31.2 1.4 7.5 8 0 0 8 8 8 2 Regulator of chromosome condensation (RCC1) repeat Kelch_2 PF07646.15 ELR12866.1 - 2.8e-11 42.9 20.6 7.5e-07 28.9 0.5 5.9 6 1 0 6 6 6 2 Kelch motif Kelch_6 PF13964.6 ELR12866.1 - 9.9e-11 41.5 20.7 4.7e-08 33.0 0.3 7.7 7 1 1 8 8 8 2 Kelch motif SRPRB PF09439.10 ELR12866.1 - 6e-07 29.1 0.0 8.9e-06 25.3 0.0 2.3 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit F-box-like PF12937.7 ELR12866.1 - 4.7e-06 26.4 0.2 4.7e-06 26.4 0.2 2.1 3 0 0 3 3 1 1 F-box-like Roc PF08477.13 ELR12866.1 - 1.2e-05 25.5 0.0 0.011 16.0 0.0 2.5 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 ELR12866.1 - 0.0048 16.5 0.0 1.3 8.6 0.0 2.4 2 0 0 2 2 2 1 Ras family F-box PF00646.33 ELR12866.1 - 0.013 15.4 0.5 0.028 14.3 0.1 1.7 2 0 0 2 2 1 0 F-box domain G-alpha PF00503.20 ELR12866.1 - 0.046 12.9 0.0 3.3 6.8 0.0 2.1 1 1 1 2 2 2 0 G-protein alpha subunit MMR_HSR1 PF01926.23 ELR12866.1 - 0.074 13.1 0.0 0.13 12.3 0.0 1.4 1 0 0 1 1 1 0 50S ribosome-binding GTPase F-box_4 PF15966.5 ELR12866.1 - 0.19 11.6 0.0 0.39 10.6 0.0 1.4 1 0 0 1 1 1 0 F-box Gtr1_RagA PF04670.12 ELR12866.1 - 0.23 10.8 0.0 0.47 9.8 0.0 1.4 1 1 0 1 1 1 0 Gtr1/RagA G protein conserved region 6PF2K PF01591.18 ELR12866.1 - 0.26 10.6 0.0 0.41 9.9 0.0 1.1 1 0 0 1 1 1 0 6-phosphofructo-2-kinase RhoGEF PF00621.20 ELR12867.1 - 2.8e-43 148.3 0.4 5.6e-43 147.3 0.4 1.5 1 0 0 1 1 1 1 RhoGEF domain Ank_4 PF13637.6 ELR12867.1 - 1.9e-25 88.9 4.2 1.7e-10 41.2 0.3 5.8 2 2 4 6 6 6 5 Ankyrin repeats (many copies) Ank_2 PF12796.7 ELR12867.1 - 2.3e-22 79.4 16.0 9.2e-10 39.0 0.1 3.8 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank_5 PF13857.6 ELR12867.1 - 6.6e-20 70.9 4.1 3.3e-07 30.5 0.1 3.9 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 ELR12867.1 - 1.6e-17 61.7 3.3 0.00012 22.2 0.0 5.9 6 0 0 6 6 6 4 Ankyrin repeat Ank PF00023.30 ELR12867.1 - 1.3e-15 57.0 6.1 4.6e-06 26.8 0.0 5.9 6 0 0 6 6 6 3 Ankyrin repeat IQ_SEC7_PH PF16453.5 ELR12867.1 - 0.0024 17.8 0.1 0.0063 16.5 0.1 1.7 1 0 0 1 1 1 1 PH domain PH_16 PF17838.1 ELR12867.1 - 0.015 15.2 0.6 0.22 11.4 0.1 2.6 3 0 0 3 3 3 0 PH domain PH_10 PF15411.6 ELR12867.1 - 0.028 14.7 0.2 0.028 14.7 0.2 2.9 3 0 0 3 3 3 0 Pleckstrin homology domain PH PF00169.29 ELR12867.1 - 0.038 14.5 0.1 0.087 13.3 0.1 1.6 1 0 0 1 1 1 0 PH domain Lzipper-MIP1 PF14389.6 ELR12867.1 - 0.15 12.4 3.1 0.31 11.4 0.1 2.9 3 0 0 3 3 3 0 Leucine-zipper of ternary complex factor MIP1 ER PF01133.17 ELR12868.1 - 2.9e-38 129.8 0.8 3.6e-38 129.5 0.8 1.1 1 0 0 1 1 1 1 Enhancer of rudimentary Capsule_synth PF05159.14 ELR12868.1 - 0.011 15.3 0.0 0.011 15.3 0.0 1.2 1 0 0 1 1 1 0 Capsule polysaccharide biosynthesis protein MutS_V PF00488.21 ELR12869.1 - 1.3e-38 132.9 0.0 2.1e-38 132.2 0.0 1.3 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.18 ELR12869.1 - 2.3e-05 24.7 0.0 3.9e-05 23.9 0.0 1.5 1 1 0 1 1 1 1 MutS domain III MutS_IV PF05190.18 ELR12869.1 - 0.00051 20.3 0.0 0.00095 19.5 0.0 1.5 1 0 0 1 1 1 1 MutS family domain IV AAA_29 PF13555.6 ELR12869.1 - 0.11 12.3 0.0 0.23 11.2 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_16 PF13191.6 ELR12869.1 - 0.13 12.6 0.1 0.69 10.3 0.1 2.1 1 1 0 2 2 2 0 AAA ATPase domain CLU PF13236.6 ELR12870.1 - 4.2e-63 213.1 0.1 3.4e-48 164.4 0.0 2.6 2 0 0 2 2 2 2 Clustered mitochondria eIF3_p135 PF12807.7 ELR12870.1 - 2.4e-41 141.7 0.1 8.9e-41 139.8 0.0 2.1 2 0 0 2 2 1 1 Translation initiation factor eIF3 subunit 135 TPR_12 PF13424.6 ELR12870.1 - 4.6e-27 94.1 13.9 4.1e-12 46.2 0.1 4.4 1 1 3 4 4 4 4 Tetratricopeptide repeat CLU_N PF15044.6 ELR12870.1 - 3.1e-14 53.1 0.2 3.2e-13 49.8 0.0 2.5 2 0 0 2 2 2 1 Mitochondrial function, CLU-N-term TPR_10 PF13374.6 ELR12870.1 - 4.7e-14 51.7 14.4 8.8e-06 25.4 0.3 5.5 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_2 PF07719.17 ELR12870.1 - 1.9e-09 36.9 2.1 0.035 14.2 0.0 5.1 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_16 PF13432.6 ELR12870.1 - 3.6e-05 24.3 0.7 0.23 12.2 0.2 3.6 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 ELR12870.1 - 5e-05 22.9 5.9 0.039 13.8 0.0 4.8 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_8 PF13181.6 ELR12870.1 - 0.00015 21.7 1.2 0.034 14.4 0.1 4.1 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_MalT PF17874.1 ELR12870.1 - 0.00057 19.4 2.1 0.0018 17.8 0.3 2.2 1 1 1 2 2 2 1 MalT-like TPR region DUF727 PF05303.12 ELR12870.1 - 0.005 16.9 0.0 0.014 15.4 0.0 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF727) TPR_14 PF13428.6 ELR12870.1 - 0.0066 17.2 0.0 1.6 9.7 0.0 3.3 3 0 0 3 3 2 1 Tetratricopeptide repeat TPR_7 PF13176.6 ELR12870.1 - 0.049 13.7 1.4 0.85 9.8 0.1 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_19 PF14559.6 ELR12870.1 - 0.054 14.0 0.6 0.97 10.0 0.0 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_6 PF13174.6 ELR12870.1 - 0.18 12.5 1.0 8.5 7.3 0.2 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_9 PF13371.6 ELR12870.1 - 0.31 11.2 1.0 7.1 6.9 0.1 3.5 3 1 0 3 3 3 0 Tetratricopeptide repeat GST_C_6 PF17171.4 ELR12870.1 - 1.7 8.5 3.8 16 5.4 0.0 3.9 4 0 0 4 4 4 0 Glutathione S-transferase, C-terminal domain Myb_DNA-bind_6 PF13921.6 ELR12871.1 - 1.2e-07 31.9 0.0 0.00066 19.9 0.0 2.2 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-binding PF00249.31 ELR12871.1 - 0.0001 22.4 0.1 0.23 11.7 0.0 2.3 2 0 0 2 2 2 2 Myb-like DNA-binding domain CKAP2_C PF15297.6 ELR12872.1 - 0.0011 18.1 0.1 0.16 11.0 0.0 2.3 2 0 0 2 2 2 2 Cytoskeleton-associated protein 2 C-terminus TMEM171 PF15471.6 ELR12872.1 - 2.3 7.1 4.9 4.6 6.1 4.9 1.4 1 0 0 1 1 1 0 Transmembrane protein family 171 Mito_fiss_reg PF05308.11 ELR12873.1 - 0.15 12.1 2.0 0.22 11.6 2.0 1.2 1 0 0 1 1 1 0 Mitochondrial fission regulator zf-NADH-PPase PF09297.11 ELR12873.1 - 2.1 8.1 12.0 1.2 8.9 0.2 4.0 3 1 0 3 3 3 0 NADH pyrophosphatase zinc ribbon domain PRIMA1 PF16101.5 ELR12873.1 - 5.9 6.9 8.4 13 5.9 8.4 1.5 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 TACC_C PF05010.14 ELR12875.1 - 9.4e-19 68.0 22.4 1.2e-17 64.4 22.4 2.0 1 1 0 1 1 1 1 Transforming acidic coiled-coil-containing protein (TACC), C-terminal DUF1068 PF06364.12 ELR12875.1 - 0.063 13.2 8.2 0.15 12.0 8.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1068) Occludin_ELL PF07303.13 ELR12875.1 - 4.2 8.2 7.1 5.2 7.8 0.3 2.5 1 1 1 2 2 2 0 Occludin homology domain Pep3_Vps18 PF05131.14 ELR12876.1 - 1.5e-41 141.7 0.0 3e-41 140.7 0.0 1.5 1 0 0 1 1 1 1 Pep3/Vps18/deep orange family Clathrin PF00637.20 ELR12876.1 - 3.6e-11 43.1 0.7 1.5e-08 34.6 0.4 2.4 2 0 0 2 2 2 2 Region in Clathrin and VPS zf-C3HC4_2 PF13923.6 ELR12876.1 - 0.00011 22.0 2.4 0.00025 20.8 2.4 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Zn_ribbon_17 PF17120.5 ELR12876.1 - 0.00025 20.6 0.5 0.00051 19.6 0.5 1.5 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type zf-RING_2 PF13639.6 ELR12876.1 - 0.0013 19.0 1.5 0.0031 17.8 1.5 1.6 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.6 ELR12876.1 - 0.0016 18.3 1.1 0.0016 18.3 1.1 1.8 2 0 0 2 2 2 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 ELR12876.1 - 0.0045 17.0 0.9 0.013 15.6 0.9 1.7 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_11 PF17123.5 ELR12876.1 - 0.0066 16.2 3.3 0.015 15.0 3.3 1.6 1 0 0 1 1 1 1 RING-like zinc finger zf-ANAPC11 PF12861.7 ELR12876.1 - 0.018 15.1 0.0 0.31 11.1 0.2 2.4 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger RPN1_RPN2_N PF17781.1 ELR12876.1 - 0.043 13.2 0.0 0.077 12.4 0.0 1.4 1 0 0 1 1 1 0 RPN1/RPN2 N-terminal domain zf-C3H2C3 PF17122.5 ELR12876.1 - 0.053 13.6 1.5 0.12 12.5 1.5 1.6 1 0 0 1 1 1 0 Zinc-finger Vps39_2 PF10367.9 ELR12876.1 - 0.054 14.0 0.1 0.15 12.5 0.1 1.8 1 0 0 1 1 1 0 Vacuolar sorting protein 39 domain 2 Vps39_1 PF10366.9 ELR12876.1 - 0.085 13.1 0.2 0.19 12.1 0.2 1.6 1 0 0 1 1 1 0 Vacuolar sorting protein 39 domain 1 DUF2175 PF09943.9 ELR12876.1 - 0.094 13.0 0.1 0.26 11.6 0.1 1.7 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2175) zf-rbx1 PF12678.7 ELR12876.1 - 0.21 11.9 1.5 0.65 10.3 1.5 1.8 1 0 0 1 1 1 0 RING-H2 zinc finger domain LisH PF08513.11 ELR12876.1 - 9.7 6.3 6.2 1.1 9.3 0.5 2.4 3 0 0 3 3 3 0 LisH RCC1 PF00415.18 ELR12877.1 - 1.6e-41 140.7 20.0 7.5e-12 45.7 0.3 6.2 6 1 0 6 6 6 5 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 ELR12877.1 - 1.3e-08 34.4 42.8 0.0008 19.1 1.4 6.3 6 2 1 7 7 7 4 Regulator of chromosome condensation (RCC1) repeat Ribosomal_L11_N PF03946.14 ELR12878.1 - 5.1e-19 67.9 0.4 8.9e-19 67.1 0.4 1.4 1 0 0 1 1 1 1 Ribosomal protein L11, N-terminal domain Ribosomal_L11 PF00298.19 ELR12878.1 - 1.7e-14 54.1 0.1 3.3e-14 53.1 0.1 1.5 1 0 0 1 1 1 1 Ribosomal protein L11, RNA binding domain FancD2 PF14631.6 ELR12879.1 - 4.2e-143 478.5 2.9 5.9e-61 206.3 0.0 5.4 2 1 1 3 3 3 3 Fanconi anaemia protein FancD2 nuclease Med15 PF09606.10 ELR12879.1 - 2.5 6.7 9.7 3.8 6.1 9.7 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal BUD22 PF09073.10 ELR12880.1 - 1.1 8.5 17.2 0.42 9.9 9.8 2.1 2 0 0 2 2 2 0 BUD22 GEMIN8 PF15348.6 ELR12880.1 - 2.6 8.3 7.4 1.2 9.4 2.1 2.1 2 0 0 2 2 2 0 Gemini of Cajal bodies-associated protein 8 DS PF01916.17 ELR12881.1 - 1e-125 418.8 0.0 1.2e-125 418.6 0.0 1.0 1 0 0 1 1 1 1 Deoxyhypusine synthase Ank_4 PF13637.6 ELR12882.1 - 7.7e-95 310.2 19.4 1.3e-11 44.7 0.0 12.3 2 2 10 13 13 13 13 Ankyrin repeats (many copies) Ank_2 PF12796.7 ELR12882.1 - 4.9e-94 309.0 23.3 3.4e-20 72.4 0.1 7.5 2 1 4 7 7 7 7 Ankyrin repeats (3 copies) FH2 PF02181.23 ELR12882.1 - 4.4e-77 259.7 1.0 1.2e-76 258.3 1.0 1.7 1 0 0 1 1 1 1 Formin Homology 2 Domain Ank PF00023.30 ELR12882.1 - 1.5e-68 224.5 33.9 0.00021 21.6 0.0 15.4 15 0 0 15 15 15 14 Ankyrin repeat Ank_5 PF13857.6 ELR12882.1 - 6.7e-67 220.7 26.3 3.4e-10 40.0 0.2 12.8 2 2 12 14 14 14 13 Ankyrin repeats (many copies) Ank_3 PF13606.6 ELR12882.1 - 3.9e-63 201.9 17.2 0.00058 20.1 0.0 15.5 15 0 0 15 15 15 14 Ankyrin repeat Drf_FH3 PF06367.16 ELR12882.1 - 0.0017 18.0 0.0 0.0043 16.7 0.0 1.6 1 0 0 1 1 1 1 Diaphanous FH3 Domain Ribosomal_L6 PF00347.23 ELR12883.1 - 2.8e-29 101.6 6.2 8.5e-19 68.0 1.6 2.2 2 0 0 2 2 2 2 Ribosomal protein L6 DUF572 PF04502.13 ELR12884.1 - 6.3e-72 243.0 4.6 7.5e-72 242.7 4.6 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF572) DUF3123 PF11321.8 ELR12884.1 - 0.055 14.2 2.8 0.11 13.1 2.8 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3123) Pkinase PF00069.25 ELR12885.1 - 3.1e-14 53.0 0.0 7e-14 51.8 0.0 1.6 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR12885.1 - 4.4e-07 29.5 0.0 7.4e-07 28.7 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ELR12885.1 - 0.0028 17.0 0.0 0.0053 16.1 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Sel_put PF04328.13 ELR12885.1 - 0.025 14.6 1.3 0.061 13.4 1.3 1.6 1 0 0 1 1 1 0 Selenoprotein, putative CTNNB1_binding PF08347.11 ELR12885.1 - 1.3 9.2 3.3 3.8 7.7 3.3 1.8 1 0 0 1 1 1 0 N-terminal CTNNB1 binding APH PF01636.23 ELR12885.1 - 1.6 8.6 8.1 0.3 11.0 0.1 2.7 2 0 0 2 2 2 0 Phosphotransferase enzyme family Mtc PF03820.17 ELR12886.1 - 9.5e-115 382.9 0.4 1.2e-114 382.6 0.4 1.1 1 0 0 1 1 1 1 Tricarboxylate carrier DUF3176 PF11374.8 ELR12886.1 - 0.0065 16.7 1.6 0.013 15.7 0.2 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF3176) CH PF00307.31 ELR12888.1 - 3.6e-83 274.9 7.5 8.4e-22 77.4 0.5 4.1 4 0 0 4 4 4 4 Calponin homology (CH) domain CAMSAP_CH PF11971.8 ELR12888.1 - 1.6e-06 27.9 0.1 0.0007 19.4 0.0 2.7 2 0 0 2 2 2 2 CAMSAP CH domain CH_2 PF06294.11 ELR12888.1 - 0.00075 19.6 0.4 0.064 13.4 0.1 3.1 3 0 0 3 3 3 1 CH-like domain in sperm protein tRNA-synt_1b PF00579.25 ELR12889.1 - 2e-66 224.3 0.0 2.5e-66 224.0 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) S4 PF01479.25 ELR12889.1 - 6.6e-06 25.7 0.1 1.3e-05 24.9 0.1 1.4 1 0 0 1 1 1 1 S4 domain TyrRSs_C PF16714.5 ELR12889.1 - 8.7e-05 22.3 0.1 0.00026 20.8 0.0 1.8 1 1 1 2 2 2 1 Tyrosyl-tRNA synthetase C-terminal domain Fcf1 PF04900.12 ELR12890.1 - 1.9e-19 69.9 0.1 3.9e-19 68.9 0.1 1.5 1 0 0 1 1 1 1 Fcf1 PapA_C PF16911.5 ELR12890.1 - 0.084 13.0 0.0 0.17 12.0 0.0 1.5 1 0 0 1 1 1 0 Phthiocerol/phthiodiolone dimycocerosyl transferase C-terminus MSP1_C PF07462.11 ELR12890.1 - 4.5 5.8 6.8 6.7 5.3 6.8 1.2 1 0 0 1 1 1 0 Merozoite surface protein 1 (MSP1) C-terminus Menin PF05053.13 ELR12890.1 - 4.8 5.4 12.9 5.8 5.2 12.9 1.1 1 0 0 1 1 1 0 Menin Glyco_tranf_2_4 PF13704.6 ELR12891.1 - 0.098 13.2 0.1 0.19 12.3 0.1 1.5 1 0 0 1 1 1 0 Glycosyl transferase family 2 Pkinase PF00069.25 ELR12892.1 - 1.1e-44 152.8 0.0 8.8e-44 149.8 0.0 2.1 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR12892.1 - 1.3e-27 96.8 0.0 6.8e-25 87.8 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 ELR12892.1 - 0.058 12.7 0.0 1.4 8.2 0.0 2.1 2 0 0 2 2 2 0 Kinase-like Ank_5 PF13857.6 ELR12893.1 - 8.9e-16 57.8 0.6 3.6e-08 33.5 0.1 2.6 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 ELR12893.1 - 2.9e-15 56.4 0.5 1.8e-09 37.9 0.1 3.4 1 1 2 3 3 3 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 ELR12893.1 - 2e-12 47.5 0.0 5.8e-12 46.0 0.0 1.8 1 1 1 2 2 2 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 ELR12893.1 - 1.1e-10 40.7 0.5 0.0039 17.6 0.0 3.9 3 0 0 3 3 3 3 Ankyrin repeat Ank PF00023.30 ELR12893.1 - 1.6e-10 40.9 0.1 6.4e-06 26.4 0.0 3.4 3 0 0 3 3 3 2 Ankyrin repeat RA PF00788.23 ELR12893.1 - 2.7e-08 34.3 0.0 5.7e-08 33.3 0.0 1.5 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain TF_Zn_Ribbon PF08271.12 ELR12893.1 - 0.0016 17.9 3.3 0.0037 16.7 3.3 1.6 1 0 0 1 1 1 1 TFIIB zinc-binding zf_Rg PF17915.1 ELR12893.1 - 0.015 14.7 0.1 0.037 13.4 0.1 1.7 1 0 0 1 1 1 0 Reverse gyrase zinc finger Zn_Tnp_IS1595 PF12760.7 ELR12893.1 - 0.022 14.7 1.9 0.046 13.7 1.9 1.5 1 0 0 1 1 1 0 Transposase zinc-ribbon domain RRM_1 PF00076.22 ELR12894.1 - 1.9e-11 43.6 0.0 3e-11 43.0 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Torus PF16131.5 ELR12894.1 - 1.7e-07 31.9 0.0 2.9e-07 31.2 0.0 1.4 1 0 0 1 1 1 1 Torus domain zf_CCCH_4 PF18345.1 ELR12894.1 - 1.9e-06 27.7 3.4 3.6e-06 26.8 3.4 1.5 1 0 0 1 1 1 1 Zinc finger domain zf-CCCH PF00642.24 ELR12894.1 - 0.00042 20.1 0.8 0.00093 19.1 0.8 1.5 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_3 PF15663.5 ELR12894.1 - 0.0015 18.7 0.5 0.012 15.8 0.2 2.1 2 0 0 2 2 2 1 Zinc-finger containing family DUF748 PF05359.11 ELR12894.1 - 0.0016 18.7 0.0 0.0026 17.9 0.0 1.3 1 0 0 1 1 1 1 Domain of Unknown Function (DUF748) zf-CCCH_4 PF18044.1 ELR12894.1 - 0.0056 16.4 3.3 0.011 15.5 3.3 1.5 1 0 0 1 1 1 1 CCCH-type zinc finger RRM_3 PF08777.11 ELR12894.1 - 0.058 13.4 0.0 0.12 12.5 0.0 1.4 1 0 0 1 1 1 0 RNA binding motif PyocinActivator PF11112.8 ELR12894.1 - 0.13 12.4 0.0 0.36 11.0 0.0 1.7 1 0 0 1 1 1 0 Pyocin activator protein PrtN zf-CCCH_2 PF14608.6 ELR12894.1 - 0.81 10.3 3.5 1.7 9.2 3.5 1.6 1 0 0 1 1 1 0 RNA-binding, Nab2-type zinc finger COX5B PF01215.19 ELR12895.1 - 2.3e-14 53.2 0.0 3e-14 52.8 0.0 1.2 1 0 0 1 1 1 1 Cytochrome c oxidase subunit Vb GATA PF00320.27 ELR12895.1 - 0.074 12.7 0.1 0.13 11.9 0.1 1.3 1 0 0 1 1 1 0 GATA zinc finger F-box-like PF12937.7 ELR12896.1 - 3.2e-13 49.3 0.5 3.2e-13 49.3 0.5 2.1 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 ELR12896.1 - 7.4e-10 38.5 0.2 1.9e-09 37.1 0.2 1.7 1 0 0 1 1 1 1 F-box domain LAMTOR PF15454.6 ELR12896.1 - 0.28 11.8 3.8 0.34 11.6 0.7 2.1 2 0 0 2 2 2 0 Late endosomal/lysosomal adaptor and MAPK and MTOR activator Thioredoxin_4 PF13462.6 ELR12897.1 - 3.4e-14 53.3 0.0 4.6e-14 52.9 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin DSBA PF01323.20 ELR12897.1 - 2.2e-05 24.3 0.1 0.16 11.7 0.0 2.2 2 0 0 2 2 2 2 DSBA-like thioredoxin domain BPL_LplA_LipB PF03099.19 ELR12898.1 - 7.9e-06 25.8 0.8 8.7e-05 22.4 0.1 2.1 1 1 1 2 2 2 1 Biotin/lipoate A/B protein ligase family Nse4-Nse3_bdg PF15412.6 ELR12898.1 - 0.011 15.8 0.0 0.026 14.6 0.0 1.5 1 0 0 1 1 1 0 Binding domain of Nse4/EID3 to Nse3-MAGE SLIDE PF09111.10 ELR12898.1 - 0.07 13.2 0.0 0.11 12.5 0.0 1.3 1 0 0 1 1 1 0 SLIDE DUF3533 PF12051.8 ELR12899.1 - 4.8e-23 81.7 9.2 3.6e-12 45.9 13.8 3.2 1 1 1 2 2 2 2 Protein of unknown function (DUF3533) ABC2_membrane PF01061.24 ELR12899.1 - 2.5 7.5 22.4 0.07 12.5 16.2 1.6 2 0 0 2 2 2 0 ABC-2 type transporter p450 PF00067.22 ELR12900.1 - 1.3e-92 311.0 0.0 1.6e-92 310.7 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 adh_short PF00106.25 ELR12901.1 - 1.4e-28 99.7 0.1 1.8e-28 99.3 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ELR12901.1 - 3.3e-26 92.3 0.1 4.3e-26 91.9 0.1 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Glyco_tranf_2_4 PF13704.6 ELR12902.1 - 2.6e-05 24.7 0.8 0.17 12.4 0.1 3.1 2 1 0 3 3 3 2 Glycosyl transferase family 2 Glyco_transf_92 PF01697.27 ELR12902.1 - 0.037 13.7 0.7 5.5 6.5 0.0 2.5 1 1 1 2 2 2 0 Glycosyltransferase family 92 DUF4169 PF13770.6 ELR12902.1 - 0.61 10.4 3.4 23 5.3 0.3 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4169) YhhN PF07947.14 ELR12903.1 - 1.1e-28 100.1 15.7 1.6e-28 99.5 15.7 1.2 1 0 0 1 1 1 1 YhhN family ThrE PF06738.12 ELR12903.1 - 2 7.7 11.4 3.5 6.9 11.4 1.4 1 0 0 1 1 1 0 Putative threonine/serine exporter F-box-like PF12937.7 ELR12904.1 - 2.7e-09 36.8 1.7 5.6e-09 35.7 1.7 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ELR12904.1 - 4.5e-06 26.4 1.2 4.5e-06 26.4 1.2 2.2 2 0 0 2 2 2 1 F-box domain NST1 PF13945.6 ELR12904.1 - 0.22 11.6 2.4 0.46 10.6 2.4 1.5 1 0 0 1 1 1 0 Salt tolerance down-regulator ABC_tran PF00005.27 ELR12905.1 - 4.6e-24 85.5 0.0 5.6e-17 62.5 0.0 2.5 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 ELR12905.1 - 0.016 14.6 0.0 3.2 7.1 0.0 2.4 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 ELR12905.1 - 0.077 12.7 0.0 0.2 11.4 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain ABC_membrane PF00664.23 ELR12905.1 - 0.13 11.9 3.9 0.19 11.4 0.3 2.3 2 0 0 2 2 2 0 ABC transporter transmembrane region eRF1_1 PF03463.15 ELR12906.1 - 1e-52 177.5 1.1 4.1e-52 175.6 0.6 2.0 2 0 0 2 2 2 1 eRF1 domain 1 eRF1_2 PF03464.15 ELR12906.1 - 3.8e-32 111.4 0.1 7.6e-32 110.4 0.1 1.5 1 0 0 1 1 1 1 eRF1 domain 2 eRF1_3 PF03465.15 ELR12906.1 - 6.9e-23 81.3 0.0 1.8e-22 80.0 0.0 1.7 1 0 0 1 1 1 1 eRF1 domain 3 ATP_bind_1 PF03029.17 ELR12907.1 - 4.6e-81 272.1 0.1 4.6e-81 272.1 0.1 1.4 2 0 0 2 2 1 1 Conserved hypothetical ATP binding protein GTP_EFTU PF00009.27 ELR12907.1 - 5.2e-08 32.7 0.0 2.2e-07 30.6 0.0 2.0 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain AAA_22 PF13401.6 ELR12907.1 - 6e-07 29.8 0.1 0.0014 18.9 0.0 2.8 2 1 0 2 2 2 2 AAA domain MMR_HSR1 PF01926.23 ELR12907.1 - 1.3e-06 28.5 0.0 2.9e-05 24.1 0.0 2.6 2 1 0 2 2 2 1 50S ribosome-binding GTPase cobW PF02492.19 ELR12907.1 - 1.4e-06 28.1 0.1 1.5e-05 24.7 0.1 2.4 1 1 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain AAA_24 PF13479.6 ELR12907.1 - 3.4e-05 23.7 0.2 0.0001 22.1 0.0 1.8 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.6 ELR12907.1 - 4.3e-05 24.1 0.7 0.0099 16.4 0.0 2.7 2 1 0 2 2 2 1 AAA domain AAA_33 PF13671.6 ELR12907.1 - 0.00012 22.3 0.1 0.00041 20.5 0.0 2.0 2 1 0 2 2 2 1 AAA domain AAA_16 PF13191.6 ELR12907.1 - 0.00018 22.0 0.2 0.0014 19.0 0.2 2.4 1 1 0 1 1 1 1 AAA ATPase domain Arf PF00025.21 ELR12907.1 - 0.00018 21.0 0.0 0.0078 15.7 0.0 2.8 2 1 0 2 2 2 1 ADP-ribosylation factor family FeoB_N PF02421.18 ELR12907.1 - 0.00027 20.5 0.0 0.012 15.2 0.0 2.4 2 0 0 2 2 2 1 Ferrous iron transport protein B NACHT PF05729.12 ELR12907.1 - 0.00027 20.9 0.1 0.001 19.0 0.0 1.9 2 0 0 2 2 2 1 NACHT domain AAA_30 PF13604.6 ELR12907.1 - 0.0003 20.6 0.0 0.0012 18.6 0.0 1.9 2 0 0 2 2 2 1 AAA domain MeaB PF03308.16 ELR12907.1 - 0.00032 19.8 0.2 0.17 10.9 0.0 2.2 2 0 0 2 2 2 2 Methylmalonyl Co-A mutase-associated GTPase MeaB RsgA_GTPase PF03193.16 ELR12907.1 - 0.00032 20.6 0.1 0.56 10.1 0.0 3.0 3 1 0 3 3 3 1 RsgA GTPase SRP54 PF00448.22 ELR12907.1 - 0.00035 20.3 0.0 0.0045 16.7 0.0 2.3 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain PduV-EutP PF10662.9 ELR12907.1 - 0.00051 19.8 0.0 0.019 14.7 0.0 2.5 3 0 0 3 3 2 1 Ethanolamine utilisation - propanediol utilisation Adeno_IVa2 PF02456.15 ELR12907.1 - 0.00088 18.2 0.0 0.0014 17.5 0.0 1.3 1 0 0 1 1 1 1 Adenovirus IVa2 protein G-alpha PF00503.20 ELR12907.1 - 0.0011 18.2 1.6 0.42 9.7 0.0 2.8 2 1 1 3 3 3 1 G-protein alpha subunit NB-ARC PF00931.22 ELR12907.1 - 0.0012 18.1 0.5 0.0025 17.0 0.0 1.8 2 0 0 2 2 2 1 NB-ARC domain Zeta_toxin PF06414.12 ELR12907.1 - 0.0022 17.3 0.0 0.0047 16.2 0.0 1.6 1 0 0 1 1 1 1 Zeta toxin AAA_7 PF12775.7 ELR12907.1 - 0.0046 16.5 0.0 0.0086 15.6 0.0 1.4 1 0 0 1 1 1 1 P-loop containing dynein motor region ATPase_2 PF01637.18 ELR12907.1 - 0.0056 16.6 0.2 0.066 13.1 0.0 2.3 2 1 1 3 3 3 1 ATPase domain predominantly from Archaea Thymidylate_kin PF02223.17 ELR12907.1 - 0.0062 16.2 0.4 0.099 12.3 0.0 2.3 2 0 0 2 2 2 1 Thymidylate kinase CLP1_P PF16575.5 ELR12907.1 - 0.0076 16.1 0.0 1.4 8.6 0.0 2.8 3 0 0 3 3 3 1 mRNA cleavage and polyadenylation factor CLP1 P-loop AAA_19 PF13245.6 ELR12907.1 - 0.0089 16.4 0.1 0.054 13.8 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_14 PF13173.6 ELR12907.1 - 0.01 15.9 0.1 0.034 14.2 0.0 2.0 2 0 0 2 2 1 1 AAA domain Roc PF08477.13 ELR12907.1 - 0.014 15.6 0.0 0.55 10.5 0.0 2.5 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 ELR12907.1 - 0.018 14.5 0.5 0.29 10.5 0.0 2.4 3 0 0 3 3 2 0 Signal recognition particle receptor beta subunit AAA_5 PF07728.14 ELR12907.1 - 0.025 14.6 0.0 0.047 13.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) Viral_helicase1 PF01443.18 ELR12907.1 - 0.026 14.3 0.0 0.066 12.9 0.0 1.7 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase CbiA PF01656.23 ELR12907.1 - 0.027 14.5 0.0 0.044 13.9 0.0 1.4 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain Dynamin_N PF00350.23 ELR12907.1 - 0.029 14.4 0.5 0.88 9.6 0.0 3.0 2 1 0 2 2 2 0 Dynamin family FtsK_SpoIIIE PF01580.18 ELR12907.1 - 0.034 13.5 2.7 0.77 9.1 0.2 3.0 2 1 1 3 3 3 0 FtsK/SpoIIIE family AAA_28 PF13521.6 ELR12907.1 - 0.045 14.0 0.9 0.24 11.6 0.0 2.4 2 1 1 3 3 3 0 AAA domain PRK PF00485.18 ELR12907.1 - 0.047 13.4 0.1 0.19 11.4 0.0 2.1 2 1 1 3 3 2 0 Phosphoribulokinase / Uridine kinase family Ras PF00071.22 ELR12907.1 - 0.049 13.2 0.0 8 6.0 0.0 2.4 2 0 0 2 2 2 0 Ras family Ploopntkinase3 PF18751.1 ELR12907.1 - 0.053 13.4 0.2 1.7 8.5 0.0 2.2 2 0 0 2 2 2 0 P-loop Nucleotide Kinase3 DUF87 PF01935.17 ELR12907.1 - 0.063 13.4 0.9 1 9.4 0.0 2.5 2 1 0 2 2 2 0 Helicase HerA, central domain MobB PF03205.14 ELR12907.1 - 0.069 13.1 0.0 0.16 11.9 0.0 1.6 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B APS_kinase PF01583.20 ELR12907.1 - 0.072 13.0 0.0 0.18 11.7 0.0 1.7 1 0 0 1 1 1 0 Adenylylsulphate kinase PhoH PF02562.16 ELR12907.1 - 0.086 12.3 0.0 0.26 10.7 0.0 1.7 2 0 0 2 2 2 0 PhoH-like protein AAA_17 PF13207.6 ELR12907.1 - 0.091 13.2 2.3 1.2 9.6 0.0 2.5 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 ELR12907.1 - 0.11 12.8 0.9 1.1 9.7 0.0 2.8 4 0 0 4 4 2 0 RNA helicase NurA PF09376.10 ELR12907.1 - 0.12 12.0 1.0 0.55 9.9 1.5 1.6 1 1 1 2 2 2 0 NurA domain AAA_23 PF13476.6 ELR12907.1 - 4 7.9 0.0 4 7.9 0.0 2.5 2 1 0 2 2 1 0 AAA domain Pkinase PF00069.25 ELR12908.1 - 3.8e-76 255.9 0.0 4.9e-76 255.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR12908.1 - 2.5e-35 122.0 0.0 3.4e-35 121.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ELR12908.1 - 0.00015 21.2 0.1 0.0041 16.5 0.0 2.1 2 0 0 2 2 2 1 Kinase-like Seadorna_VP7 PF07387.11 ELR12908.1 - 0.0017 17.5 0.1 0.0028 16.8 0.1 1.3 1 0 0 1 1 1 1 Seadornavirus VP7 FTA2 PF13095.6 ELR12908.1 - 0.0046 16.6 0.1 0.53 9.9 0.1 2.2 2 0 0 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 Pkinase_fungal PF17667.1 ELR12908.1 - 0.0095 14.7 0.0 0.016 14.0 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 ELR12908.1 - 0.051 13.5 0.2 0.73 9.7 0.0 2.0 1 1 1 2 2 2 0 Phosphotransferase enzyme family Haspin_kinase PF12330.8 ELR12908.1 - 0.17 10.8 0.3 0.37 9.7 0.3 1.6 1 1 0 1 1 1 0 Haspin like kinase domain Dus PF01207.17 ELR12909.1 - 2.9e-71 240.1 0.0 3.7e-71 239.8 0.0 1.1 1 0 0 1 1 1 1 Dihydrouridine synthase (Dus) His_biosynth PF00977.21 ELR12909.1 - 0.22 10.9 0.0 0.39 10.2 0.0 1.4 1 0 0 1 1 1 0 Histidine biosynthesis protein Ras PF00071.22 ELR12910.1 - 2.4e-35 121.5 0.0 5.7e-33 113.8 0.0 2.1 1 1 0 1 1 1 1 Ras family Roc PF08477.13 ELR12910.1 - 4.7e-19 68.8 0.0 5.4e-18 65.3 0.0 2.1 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR12910.1 - 6.3e-09 35.5 0.1 2.3e-07 30.4 0.0 2.1 1 1 1 2 2 2 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 ELR12910.1 - 6.1e-05 23.1 0.0 7.8e-05 22.7 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 ELR12910.1 - 0.00031 20.2 0.0 0.00043 19.7 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 ELR12910.1 - 0.00073 19.1 0.1 0.045 13.3 0.2 3.0 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain AAA_24 PF13479.6 ELR12910.1 - 0.0027 17.5 0.0 0.0048 16.7 0.0 1.4 1 1 0 1 1 1 1 AAA domain RsgA_GTPase PF03193.16 ELR12910.1 - 0.01 15.7 0.0 2.9 7.8 0.0 2.2 2 0 0 2 2 2 0 RsgA GTPase NACHT PF05729.12 ELR12910.1 - 0.019 14.9 0.0 0.061 13.2 0.0 1.7 2 0 0 2 2 2 0 NACHT domain AAA_7 PF12775.7 ELR12910.1 - 0.024 14.1 0.0 0.041 13.4 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region TsaE PF02367.17 ELR12910.1 - 0.03 14.3 0.0 0.048 13.7 0.0 1.3 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Pox_A32 PF04665.12 ELR12910.1 - 0.038 13.4 0.0 0.061 12.8 0.0 1.2 1 0 0 1 1 1 0 Poxvirus A32 protein Sigma54_activat PF00158.26 ELR12910.1 - 0.044 13.5 0.0 0.071 12.8 0.0 1.5 1 1 0 1 1 1 0 Sigma-54 interaction domain G-alpha PF00503.20 ELR12910.1 - 0.062 12.5 0.0 0.19 10.9 0.0 1.8 1 1 0 2 2 2 0 G-protein alpha subunit AAA_16 PF13191.6 ELR12910.1 - 0.066 13.6 0.1 0.12 12.8 0.0 1.6 2 1 0 2 2 2 0 AAA ATPase domain Septin PF00735.18 ELR12910.1 - 0.071 12.4 0.0 0.13 11.5 0.0 1.4 1 0 0 1 1 1 0 Septin ATP_bind_1 PF03029.17 ELR12910.1 - 0.095 12.5 0.0 7 6.4 0.0 2.2 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein ABC_tran PF00005.27 ELR12910.1 - 0.11 12.9 0.0 0.25 11.9 0.0 1.6 1 0 0 1 1 1 0 ABC transporter TniB PF05621.11 ELR12910.1 - 0.13 11.6 0.0 0.21 11.0 0.0 1.3 1 0 0 1 1 1 0 Bacterial TniB protein AAA_33 PF13671.6 ELR12910.1 - 0.14 12.3 0.0 0.2 11.8 0.0 1.7 1 1 0 1 1 1 0 AAA domain AAA_32 PF13654.6 ELR12910.1 - 0.17 10.7 0.0 0.23 10.2 0.0 1.2 1 0 0 1 1 1 0 AAA domain Ras PF00071.22 ELR12911.1 - 2e-38 131.5 0.0 2.6e-38 131.2 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR12911.1 - 2.9e-19 69.4 0.0 4.5e-19 68.8 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR12911.1 - 4.8e-08 32.7 0.0 7.5e-08 32.0 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family PduV-EutP PF10662.9 ELR12911.1 - 0.022 14.5 0.0 0.36 10.6 0.0 2.1 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation RsgA_GTPase PF03193.16 ELR12911.1 - 0.023 14.6 0.0 0.8 9.6 0.0 2.1 2 0 0 2 2 2 0 RsgA GTPase MMR_HSR1 PF01926.23 ELR12911.1 - 0.041 14.0 0.0 0.058 13.5 0.0 1.4 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_7 PF12775.7 ELR12911.1 - 0.045 13.3 0.0 0.077 12.5 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region FeoB_N PF02421.18 ELR12911.1 - 0.066 12.7 0.0 5.4 6.5 0.0 2.3 2 0 0 2 2 2 0 Ferrous iron transport protein B MMR_HSR1_Xtn PF16897.5 ELR12911.1 - 0.083 12.9 0.0 0.16 12.0 0.0 1.4 1 0 0 1 1 1 0 C-terminal region of MMR_HSR1 domain ABC_tran PF00005.27 ELR12911.1 - 0.096 13.2 0.1 0.6 10.6 0.0 2.0 2 0 0 2 2 2 0 ABC transporter AAA_16 PF13191.6 ELR12911.1 - 0.11 12.9 0.1 0.43 10.9 0.0 1.8 2 0 0 2 2 2 0 AAA ATPase domain AAA_28 PF13521.6 ELR12911.1 - 0.14 12.4 0.0 0.24 11.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_21 PF13304.6 ELR12911.1 - 0.2 11.4 0.3 0.41 10.4 0.3 1.5 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system MID_MedPIWI PF18296.1 ELR12912.1 - 1.6e-22 80.5 0.0 4.5e-10 39.7 0.0 3.3 2 1 1 3 3 3 2 MID domain of medPIWI Med13_C PF06333.12 ELR12912.1 - 6.4e-18 65.1 3.2 6.4e-18 65.1 3.2 3.7 2 1 0 2 2 2 1 Mediator complex subunit 13 C-terminal domain FAM199X PF15814.5 ELR12912.1 - 0.29 10.1 8.8 0.68 8.9 8.8 1.6 1 0 0 1 1 1 0 Protein family FAM199X Phosphodiest PF01663.22 ELR12913.1 - 2.3e-11 43.9 0.1 4.2e-11 43.0 0.1 1.3 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Metalloenzyme PF01676.18 ELR12913.1 - 0.00082 18.8 0.0 0.0013 18.1 0.0 1.2 1 0 0 1 1 1 1 Metalloenzyme superfamily Sulfatase PF00884.23 ELR12913.1 - 0.058 12.8 0.1 0.18 11.1 0.1 1.7 1 1 0 1 1 1 0 Sulfatase Tom22 PF04281.13 ELR12914.1 - 0.088 12.6 0.0 0.11 12.3 0.0 1.1 1 0 0 1 1 1 0 Mitochondrial import receptor subunit Tom22 Otopetrin PF03189.13 ELR12915.1 - 0.073 11.9 0.4 0.082 11.7 0.4 1.0 1 0 0 1 1 1 0 Otopetrin Mito_morph_reg PF14972.6 ELR12915.1 - 0.23 11.0 2.4 0.24 11.0 2.4 1.1 1 0 0 1 1 1 0 Mitochondrial morphogenesis regulator Vpu PF00558.19 ELR12915.1 - 0.24 11.2 1.9 0.33 10.8 1.2 1.5 1 1 1 2 2 2 0 Vpu protein PARP PF00644.20 ELR12916.1 - 3e-18 66.1 2.5 1.4e-15 57.4 2.5 2.4 1 1 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain DEC-1_N PF04625.13 ELR12916.1 - 0.00087 18.4 1.1 0.0015 17.6 1.1 1.5 1 0 0 1 1 1 1 DEC-1 protein, N-terminal region UBZ_FAAP20 PF15750.5 ELR12916.1 - 0.015 15.2 0.2 0.031 14.2 0.2 1.5 1 0 0 1 1 1 0 Ubiquitin-binding zinc-finger zf_UBZ PF18439.1 ELR12916.1 - 0.14 11.8 0.2 0.26 10.9 0.2 1.4 1 0 0 1 1 1 0 Ubiquitin-Binding Zinc Finger zf-WRNIP1_ubi PF18279.1 ELR12916.1 - 0.16 12.6 0.5 0.37 11.5 0.5 1.6 1 0 0 1 1 1 0 Werner helicase-interacting protein 1 ubiquitin-binding domain Zn-C2H2_12 PF18112.1 ELR12916.1 - 0.18 12.3 0.3 0.45 11.0 0.3 1.6 1 0 0 1 1 1 0 Autophagy receptor zinc finger-C2H2 domain TMPIT PF07851.13 ELR12916.1 - 0.23 10.7 2.3 0.34 10.1 2.3 1.3 1 0 0 1 1 1 0 TMPIT-like protein DUF4407 PF14362.6 ELR12916.1 - 3.8 6.8 5.9 6 6.1 5.9 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) CCDC50_N PF15295.6 ELR12916.1 - 7.6 6.7 33.0 0.35 11.0 2.5 3.4 2 1 1 3 3 3 0 Coiled-coil domain-containing protein 50 N-terminus FAD-oxidase_C PF02913.19 ELR12917.1 - 1.5e-61 208.2 0.0 1.8e-61 207.9 0.0 1.1 1 0 0 1 1 1 1 FAD linked oxidases, C-terminal domain FAD_binding_4 PF01565.23 ELR12917.1 - 6.3e-38 129.7 0.2 1.2e-37 128.8 0.2 1.4 1 0 0 1 1 1 1 FAD binding domain FAD_oxidored PF12831.7 ELR12918.1 - 2.1e-42 146.0 0.0 2e-41 142.8 0.0 2.3 1 1 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 ELR12918.1 - 0.024 14.9 0.3 0.22 11.8 0.1 2.4 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 ELR12918.1 - 0.024 13.9 0.0 0.045 13.0 0.0 1.3 1 0 0 1 1 1 0 Thi4 family DUF4139 PF13598.6 ELR12919.1 - 0.00011 22.0 2.5 0.00023 20.9 2.5 1.7 1 1 0 1 1 1 1 Domain of unknown function (DUF4139) CCDC-167 PF15188.6 ELR12919.1 - 0.0036 17.6 1.7 0.013 15.8 1.7 1.9 1 0 0 1 1 1 1 Coiled-coil domain-containing protein 167 BLOC1_2 PF10046.9 ELR12919.1 - 0.02 15.2 2.1 1.9 8.8 0.1 2.8 2 0 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Dor1 PF04124.12 ELR12919.1 - 0.16 10.6 1.5 0.29 9.8 1.5 1.3 1 0 0 1 1 1 0 Dor1-like family DHR10 PF18595.1 ELR12919.1 - 0.25 11.4 6.8 4 7.5 0.1 3.0 2 0 0 2 2 2 0 Designed helical repeat protein 10 domain APG6_N PF17675.1 ELR12919.1 - 1.5 9.3 9.0 41 4.7 9.0 2.7 1 1 0 1 1 1 0 Apg6 coiled-coil region XhlA PF10779.9 ELR12919.1 - 2.5 8.4 7.7 1.1 9.5 2.7 2.5 2 0 0 2 2 2 0 Haemolysin XhlA LRR_4 PF12799.7 ELR12920.1 - 0.41 11.1 21.2 0.43 11.1 1.7 6.7 4 1 4 8 8 8 0 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 ELR12920.1 - 2.6 8.3 15.9 0.77 10.0 0.1 6.5 9 0 0 9 9 9 0 Leucine Rich repeat DUF4139 PF13598.6 ELR12921.1 - 1.6e-07 31.2 0.0 3.5e-07 30.2 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4139) PI3K_P85_iSH2 PF16454.5 ELR12921.1 - 0.035 13.7 5.3 0.08 12.5 5.3 1.5 1 0 0 1 1 1 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain FAM76 PF16046.5 ELR12921.1 - 0.053 12.9 4.4 0.075 12.4 4.4 1.2 1 0 0 1 1 1 0 FAM76 protein DUF4139 PF13598.6 ELR12922.1 - 0.017 14.8 3.4 0.032 14.0 3.4 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4139) DUF1043 PF06295.12 ELR12922.1 - 0.066 13.2 1.4 0.18 11.8 1.4 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1043) BLOC1_2 PF10046.9 ELR12922.1 - 0.095 13.0 3.6 2.6 8.4 0.3 2.8 2 0 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 F-box-like PF12937.7 ELR12923.1 - 3.4e-13 49.3 0.3 3.4e-13 49.3 0.3 2.0 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 ELR12923.1 - 7.7e-09 35.2 0.2 1.7e-08 34.1 0.2 1.6 1 0 0 1 1 1 1 F-box domain Patatin PF01734.22 ELR12923.1 - 0.15 12.2 0.0 0.17 12.1 0.0 1.2 1 0 0 1 1 1 0 Patatin-like phospholipase Mito_carr PF00153.27 ELR12924.1 - 5e-22 77.6 0.0 5.8e-22 77.4 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial carrier protein Mito_carr PF00153.27 ELR12925.1 - 3.9e-46 154.9 1.6 8.8e-24 83.3 0.1 2.0 2 0 0 2 2 2 2 Mitochondrial carrier protein F-box-like PF12937.7 ELR12926.1 - 9.8e-10 38.2 1.0 1.5e-09 37.6 0.4 1.7 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 ELR12926.1 - 3e-07 30.1 0.0 5.3e-07 29.4 0.0 1.4 1 0 0 1 1 1 1 F-box domain SPRY PF00622.28 ELR12926.1 - 0.035 14.2 0.0 0.057 13.5 0.0 1.3 1 0 0 1 1 1 0 SPRY domain MFS_1 PF07690.16 ELR12927.1 - 1e-19 70.7 51.4 4.1e-16 58.9 22.1 2.5 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1 PF07690.16 ELR12928.1 - 3.7e-18 65.6 22.4 5.9e-18 64.9 22.4 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily MFS_2 PF13347.6 ELR12928.1 - 0.0012 17.5 0.6 0.0012 17.5 0.6 1.9 1 1 1 2 2 2 1 MFS/sugar transport protein OATP PF03137.20 ELR12928.1 - 0.0074 14.6 0.1 0.0074 14.6 0.1 2.8 2 1 1 3 3 3 2 Organic Anion Transporter Polypeptide (OATP) family Nuc_H_symport PF03825.16 ELR12928.1 - 0.015 14.3 0.3 0.015 14.3 0.3 1.7 2 0 0 2 2 2 0 Nucleoside H+ symporter DUF4212 PF13937.6 ELR12928.1 - 6.5 7.2 10.0 2 8.9 0.4 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF4212) Ribosomal_L27 PF01016.19 ELR12929.1 - 1.6e-30 104.9 0.3 2.5e-30 104.3 0.3 1.3 1 0 0 1 1 1 1 Ribosomal L27 protein Transketolase_C PF02780.20 ELR12930.1 - 1.1e-41 141.5 0.0 2.4e-41 140.5 0.0 1.6 1 0 0 1 1 1 1 Transketolase, C-terminal domain Transket_pyr PF02779.24 ELR12930.1 - 3e-33 115.0 0.9 2.7e-31 108.6 0.9 2.8 1 1 0 1 1 1 1 Transketolase, pyrimidine binding domain PFOR_II PF17147.4 ELR12930.1 - 0.0024 18.2 0.0 0.0053 17.0 0.0 1.6 1 0 0 1 1 1 1 Pyruvate:ferredoxin oxidoreductase core domain II Uds1 PF15456.6 ELR12931.1 - 3.4 7.9 14.1 0.31 11.2 8.2 2.4 2 0 0 2 2 2 0 Up-regulated During Septation DUF4139 PF13598.6 ELR12932.1 - 0.039 13.6 0.0 3.8 7.2 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4139) F-112 PF09645.10 ELR12933.1 - 0.073 13.2 0.2 0.14 12.2 0.0 1.5 2 0 0 2 2 2 0 F-112 protein Shisa PF13908.6 ELR12933.1 - 4.2 7.6 6.3 7.7 6.7 6.3 1.4 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator DUF4201 PF13870.6 ELR12934.1 - 0.022 14.5 0.1 0.041 13.6 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4201) DUF5082 PF16888.5 ELR12934.1 - 0.11 12.8 0.8 0.19 12.0 0.8 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF5082) PspA_IM30 PF04012.12 ELR12934.1 - 0.12 12.0 5.7 0.082 12.5 3.2 1.8 2 0 0 2 2 2 0 PspA/IM30 family DivIC PF04977.15 ELR12934.1 - 0.12 12.2 0.1 0.12 12.2 0.1 2.2 3 0 0 3 3 3 0 Septum formation initiator DUF4139 PF13598.6 ELR12936.1 - 2.2e-05 24.3 0.7 5.4e-05 23.0 0.5 1.7 1 1 0 1 1 1 1 Domain of unknown function (DUF4139) BLOC1_2 PF10046.9 ELR12936.1 - 0.17 12.2 6.6 0.085 13.2 0.6 3.0 3 0 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 YabA PF06156.13 ELR12936.1 - 0.29 11.8 5.3 0.36 11.5 2.9 2.4 2 0 0 2 2 2 0 Initiation control protein YabA DivIC PF04977.15 ELR12936.1 - 0.75 9.6 5.4 15 5.4 1.6 2.7 2 0 0 2 2 2 0 Septum formation initiator NABP PF07990.12 ELR12936.1 - 2.6 7.5 9.2 0.083 12.4 2.6 1.8 2 0 0 2 2 2 0 Nucleic acid binding protein NABP PG_binding_4 PF12229.8 ELR12936.1 - 5.2 7.4 7.5 17 5.7 0.7 3.6 3 0 0 3 3 3 0 Putative peptidoglycan binding domain GTP_EFTU PF00009.27 ELR12937.1 - 1.2e-52 178.3 0.0 2e-52 177.6 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 ELR12937.1 - 7.6e-38 129.3 0.0 1.4e-37 128.4 0.0 1.5 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 ELR12937.1 - 5.4e-11 42.7 0.9 1.4e-10 41.4 0.9 1.8 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 ELR12937.1 - 7.4e-06 26.0 0.0 0.00011 22.2 0.0 2.3 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU_D4 PF14578.6 ELR12937.1 - 0.46 10.4 3.0 0.54 10.2 0.4 2.3 2 0 0 2 2 2 0 Elongation factor Tu domain 4 Ras PF00071.22 ELR12938.1 - 1.8e-57 193.4 0.4 2.1e-57 193.2 0.4 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR12938.1 - 1.9e-21 76.5 0.0 2.7e-21 76.0 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR12938.1 - 1.2e-09 37.9 0.1 1.4e-09 37.7 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 ELR12938.1 - 3e-05 23.6 0.7 7.6e-05 22.3 0.2 1.8 1 1 0 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 ELR12938.1 - 0.00043 20.3 0.0 0.00073 19.6 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 ELR12938.1 - 0.0022 17.9 3.0 0.49 10.3 0.0 2.2 1 1 0 2 2 2 2 RsgA GTPase RasGAP PF00616.19 ELR12939.1 - 5.5e-24 85.0 12.6 6.8e-20 71.7 0.7 3.6 4 1 1 5 5 5 2 GTPase-activator protein for Ras-like GTPase RGS PF00615.19 ELR12939.1 - 3.4e-09 37.0 0.1 1.4e-08 35.0 0.3 2.0 2 0 0 2 2 2 1 Regulator of G protein signaling domain START PF01852.19 ELR12939.1 - 0.00012 21.5 0.0 0.00029 20.3 0.0 1.6 1 0 0 1 1 1 1 START domain RNA_lig_T4_1 PF09511.10 ELR12940.1 - 1.5e-26 93.6 0.3 1.9e-25 90.0 0.3 2.1 1 1 0 1 1 1 1 RNA ligase Thrombin_light PF09396.10 ELR12940.1 - 0.0081 15.9 0.1 0.051 13.3 0.1 2.3 2 0 0 2 2 2 1 Thrombin light chain Cwf_Cwc_15 PF04889.12 ELR12940.1 - 0.045 13.5 6.0 0.068 12.9 6.0 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein APG12 PF04110.13 ELR12941.1 - 4.5e-25 87.9 0.0 5.4e-25 87.6 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-like autophagy protein Apg12 Atg8 PF02991.16 ELR12941.1 - 0.0023 18.1 0.0 0.0026 17.9 0.0 1.1 1 0 0 1 1 1 1 Autophagy protein Atg8 ubiquitin like P3A PF08727.11 ELR12941.1 - 0.15 11.4 0.0 0.29 10.6 0.0 1.4 1 0 0 1 1 1 0 Poliovirus 3A protein like Pmp3 PF01679.17 ELR12942.1 - 4.7e-18 65.1 12.3 5.5e-18 64.9 12.3 1.1 1 0 0 1 1 1 1 Proteolipid membrane potential modulator DUF872 PF05915.12 ELR12942.1 - 0.29 11.3 2.2 0.34 11.1 2.2 1.1 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF872) F-box-like PF12937.7 ELR12943.1 - 7e-11 41.8 0.7 1.3e-10 41.0 0.7 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ELR12943.1 - 3.6e-07 29.9 0.9 1e-06 28.4 0.4 2.0 2 0 0 2 2 2 1 F-box domain RB_B PF01857.20 ELR12944.1 - 0.046 13.8 0.0 0.046 13.8 0.0 1.2 1 0 0 1 1 1 0 Retinoblastoma-associated protein B domain RhoGEF PF00621.20 ELR12945.1 - 3e-26 92.8 5.8 3e-26 92.8 5.8 2.9 3 0 0 3 3 3 1 RhoGEF domain PH PF00169.29 ELR12945.1 - 2.3e-08 34.5 0.1 6.1e-08 33.1 0.1 1.7 1 0 0 1 1 1 1 PH domain Hva1_TUDOR PF11160.8 ELR12945.1 - 4 7.7 6.8 0.22 11.7 0.1 2.3 2 0 0 2 2 2 0 Hypervirulence associated proteins TUDOR domain SAPS PF04499.15 ELR12946.1 - 0.00045 19.1 0.0 0.00045 19.1 0.0 4.6 3 1 0 4 4 4 1 SIT4 phosphatase-associated protein SPX PF03105.19 ELR12946.1 - 0.0036 17.3 6.8 0.0036 17.3 6.8 4.6 3 2 0 3 3 3 1 SPX domain Ecl1 PF12855.7 ELR12946.1 - 0.021 16.0 8.7 0.021 16.0 8.7 5.2 4 2 1 5 5 5 0 ECL1/2/3 zinc binding proteins Lin-8 PF03353.15 ELR12946.1 - 4.7 6.7 30.9 0.2 11.2 7.6 3.5 3 0 0 3 3 3 0 Ras-mediated vulval-induction antagonist BRCT_3 PF18428.1 ELR12947.1 - 1.1e-05 25.4 0.0 0.00032 20.7 0.0 2.8 2 0 0 2 2 2 1 BRCA1 C Terminus (BRCT) domain BRCT PF00533.26 ELR12947.1 - 1.5e-05 25.3 0.0 4.1e-05 23.9 0.0 1.8 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 ELR12947.1 - 0.0012 19.2 0.0 0.015 15.7 0.0 2.7 3 0 0 3 3 3 1 BRCT domain, a BRCA1 C-terminus domain Mucin PF01456.17 ELR12947.1 - 4.7 7.2 19.1 21 5.1 19.1 2.1 1 0 0 1 1 1 0 Mucin-like glycoprotein HLH PF00010.26 ELR12948.1 - 1.9e-09 37.3 0.5 4.4e-09 36.2 0.5 1.6 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain UvsY PF11056.8 ELR12948.1 - 0.81 10.0 3.8 0.44 10.9 0.1 2.0 2 0 0 2 2 2 0 Recombination, repair and ssDNA binding protein UvsY Rho_N PF07498.12 ELR12949.1 - 1e-06 28.5 0.2 0.013 15.4 0.0 2.5 2 0 0 2 2 2 2 Rho termination factor, N-terminal domain SAP PF02037.27 ELR12949.1 - 6.3e-06 25.8 0.4 0.05 13.4 0.0 3.4 3 0 0 3 3 3 3 SAP domain SPC22 PF04573.12 ELR12949.1 - 0.039 13.4 0.0 0.095 12.2 0.0 1.6 1 0 0 1 1 1 0 Signal peptidase subunit NTP_transf_2 PF01909.23 ELR12951.1 - 4.3e-06 26.9 0.0 8.6e-06 26.0 0.0 1.5 1 0 0 1 1 1 1 Nucleotidyltransferase domain UPF0261 PF06792.11 ELR12952.1 - 3.9e-129 431.1 0.4 4.8e-129 430.8 0.4 1.1 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0261) PEP_hydrolase PF09370.10 ELR12952.1 - 2.9e-63 213.6 0.3 5.6e-63 212.7 0.3 1.4 1 0 0 1 1 1 1 Phosphoenolpyruvate hydrolase-like PEP_hydrolase PF09370.10 ELR12953.1 - 8.4e-66 221.9 0.3 9.2e-66 221.8 0.3 1.0 1 0 0 1 1 1 1 Phosphoenolpyruvate hydrolase-like NMO PF03060.15 ELR12953.1 - 0.00023 20.7 0.2 0.00028 20.4 0.2 1.1 1 0 0 1 1 1 1 Nitronate monooxygenase Lyase_8 PF02278.18 ELR12955.1 - 2.6e-66 223.7 0.0 3.9e-66 223.2 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide lyase family 8, super-sandwich domain Lyase_8_N PF08124.11 ELR12955.1 - 2.6e-26 92.3 0.0 4.5e-26 91.5 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide lyase family 8, N terminal alpha-helical domain Lyase_8_C PF02884.17 ELR12955.1 - 5.2e-09 36.4 0.0 1.4e-08 35.0 0.0 1.8 1 0 0 1 1 1 1 Polysaccharide lyase family 8, C-terminal beta-sandwich domain Lyase_catalyt PF09093.11 ELR12955.1 - 0.0047 16.1 0.1 0.0081 15.3 0.1 1.3 1 0 0 1 1 1 1 Lyase, catalytic MYCBPAP PF14646.6 ELR12956.1 - 0.0031 16.5 1.3 0.0032 16.5 1.3 1.0 1 0 0 1 1 1 1 MYCBP-associated protein family DUF2635 PF10948.8 ELR12956.1 - 0.49 10.2 2.4 1.1 9.0 0.1 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF2635) SPX PF03105.19 ELR12957.1 - 0.00071 19.6 6.7 0.00071 19.6 6.7 2.5 2 1 0 2 2 2 1 SPX domain PAS_9 PF13426.7 ELR12957.1 - 0.0014 18.9 0.0 0.0042 17.3 0.0 1.8 1 0 0 1 1 1 1 PAS domain DUF2828 PF11443.8 ELR12957.1 - 0.18 9.9 4.8 0.28 9.2 4.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) Pinin_SDK_memA PF04696.13 ELR12957.1 - 0.26 11.4 28.4 0.055 13.5 23.1 2.2 2 0 0 2 2 2 0 pinin/SDK/memA/ protein conserved region PAS PF00989.25 ELR12957.1 - 0.57 10.2 0.0 0.57 10.2 0.0 2.3 2 0 0 2 2 2 0 PAS fold Exonuc_VII_L PF02601.15 ELR12957.1 - 8.1 5.9 9.7 15 5.0 9.7 1.4 1 0 0 1 1 1 0 Exonuclease VII, large subunit BCNT PF07572.12 ELR12958.1 - 3.4e-18 65.5 1.3 3.4e-18 65.5 1.3 1.8 2 0 0 2 2 2 1 Bucentaur or craniofacial development CDRT4 PF15213.6 ELR12958.1 - 0.19 12.3 3.0 0.47 11.1 3.0 1.6 1 0 0 1 1 1 0 CMT1A duplicated region transcript 4 protein Rrn6 PF10214.9 ELR12958.1 - 0.32 9.5 9.1 0.52 8.7 9.1 1.3 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor Selenoprotein_S PF06936.11 ELR12958.1 - 0.79 9.5 8.7 0.25 11.1 4.4 2.1 2 0 0 2 2 2 0 Selenoprotein S (SelS) MCPVI PF02993.14 ELR12958.1 - 0.99 9.2 12.7 3.5 7.4 12.7 1.8 1 1 0 1 1 1 0 Minor capsid protein VI CBM49 PF09478.10 ELR12959.1 - 3.6e-09 36.8 0.5 0.00051 20.3 0.1 2.2 2 0 0 2 2 2 2 Carbohydrate binding domain CBM49 HSP70 PF00012.20 ELR12960.1 - 3.1e-214 712.6 6.3 3.6e-214 712.4 6.3 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 ELR12960.1 - 2e-14 53.2 0.1 2.2e-13 49.7 0.0 2.1 2 0 0 2 2 2 1 MreB/Mbl protein StbA PF06406.11 ELR12960.1 - 0.0072 15.6 0.3 0.083 12.1 0.0 2.5 3 0 0 3 3 3 1 StbA protein DUF4259 PF14078.6 ELR12960.1 - 1.8 9.3 5.7 10 6.8 0.1 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4259) Glyco_hydro_130 PF04041.13 ELR12961.1 - 5.4e-23 81.4 0.0 7.1e-23 81.0 0.0 1.1 1 0 0 1 1 1 1 beta-1,4-mannooligosaccharide phosphorylase Complex1_51K PF01512.17 ELR12962.1 - 3.9e-49 166.4 0.0 6.3e-49 165.7 0.0 1.3 1 0 0 1 1 1 1 Respiratory-chain NADH dehydrogenase 51 Kd subunit NADH_4Fe-4S PF10589.9 ELR12962.1 - 1.2e-28 99.0 0.0 2.2e-28 98.2 0.0 1.4 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region SLBB PF10531.9 ELR12962.1 - 1.2e-07 31.5 0.0 2.2e-07 30.6 0.0 1.5 1 0 0 1 1 1 1 SLBB domain Cystatin PF00031.21 ELR12964.1 - 4.1e-11 43.0 0.0 4.7e-11 42.8 0.0 1.2 1 0 0 1 1 1 1 Cystatin domain MORN PF02493.20 ELR12965.1 - 6.2e-82 264.9 98.2 3.7e-07 29.7 2.2 17.4 17 0 0 17 17 17 17 MORN repeat RhoGEF PF00621.20 ELR12965.1 - 1.4e-46 159.0 0.8 2.4e-46 158.2 0.8 1.4 1 0 0 1 1 1 1 RhoGEF domain WH1 PF00568.23 ELR12965.1 - 3.2e-12 46.4 2.8 3.6e-12 46.2 0.7 2.2 2 0 0 2 2 2 1 WH1 domain PH PF00169.29 ELR12965.1 - 0.0087 16.6 0.1 0.038 14.5 0.0 2.0 2 0 0 2 2 2 1 PH domain zf-C2H2 PF00096.26 ELR12966.1 - 2.1e-31 106.6 51.5 2.8e-06 27.5 0.4 7.3 7 0 0 7 7 7 7 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 ELR12966.1 - 1.8e-21 74.9 44.7 0.00096 19.8 0.3 7.3 7 0 0 7 7 7 7 C2H2-type zinc finger zf-H2C2_2 PF13465.6 ELR12966.1 - 3.6e-12 46.1 52.7 8e-06 26.1 0.3 9.6 10 0 0 10 10 10 3 Zinc-finger double domain zf-C2H2_3rep PF18868.1 ELR12966.1 - 4.5e-09 37.0 13.2 0.00073 20.2 0.2 5.1 1 1 4 5 5 5 3 Zinc finger C2H2-type, 3 repeats zf-C2H2_8 PF15909.5 ELR12966.1 - 6.8e-08 32.7 19.8 0.00053 20.2 1.3 5.0 3 2 1 5 5 5 3 C2H2-type zinc ribbon zf-C2H2_jaz PF12171.8 ELR12966.1 - 1.4e-07 31.6 23.9 0.29 11.5 0.4 6.6 6 0 0 6 6 6 4 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 ELR12966.1 - 3.6e-07 30.3 24.9 0.044 14.2 2.1 6.3 6 0 0 6 6 6 3 Zinc-finger of C2H2 type zf-C2H2_11 PF16622.5 ELR12966.1 - 8e-07 28.7 26.3 0.00054 19.7 0.1 6.5 6 0 0 6 6 6 3 zinc-finger C2H2-type FOXP-CC PF16159.5 ELR12966.1 - 8.8e-06 26.3 20.9 0.069 13.8 0.1 6.3 5 2 1 6 6 6 2 FOXP coiled-coil domain zf-H2C2_5 PF13909.6 ELR12966.1 - 5.8e-05 22.8 2.3 0.00021 20.9 0.5 7.3 8 1 0 8 8 7 3 C2H2-type zinc-finger domain zf-Di19 PF05605.12 ELR12966.1 - 0.013 15.8 2.2 0.013 15.8 2.2 4.8 5 1 0 5 5 4 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_9 PF16293.5 ELR12966.1 - 0.21 11.5 4.4 21 5.0 0.2 4.1 3 1 1 4 4 4 0 C2H2 type zinc-finger (1 copy) zf-C2H2_aberr PF17017.5 ELR12966.1 - 0.61 10.2 13.7 3.1 7.9 0.0 4.9 4 1 1 5 5 5 0 Aberrant zinc-finger zf-C2H2_2 PF12756.7 ELR12966.1 - 1.7 9.0 27.3 0.32 11.3 1.5 5.6 3 3 3 6 6 6 0 C2H2 type zinc-finger (2 copies) GAGA PF09237.11 ELR12966.1 - 2.4 8.0 13.4 1.9 8.3 0.0 4.5 3 2 1 4 4 4 0 GAGA factor zf-C2H2_6 PF13912.6 ELR12966.1 - 2.5 8.2 32.8 2.7 8.1 0.2 7.2 7 0 0 7 7 7 0 C2H2-type zinc finger zinc-ribbons_6 PF07191.12 ELR12966.1 - 3 7.9 10.9 2.1 8.4 1.6 3.2 2 2 0 2 2 2 0 zinc-ribbons UCR_TM PF02921.14 ELR12966.1 - 3.9 8.0 6.1 28 5.3 0.5 2.7 2 0 0 2 2 2 0 Ubiquinol cytochrome reductase transmembrane region zf-C2HE PF16278.5 ELR12966.1 - 4.7 7.7 29.4 10 6.6 1.6 5.5 5 2 1 6 6 5 0 C2HE / C2H2 / C2HC zinc-binding finger CpXC PF14353.6 ELR12966.1 - 8.4 6.5 16.5 32 4.6 0.4 4.7 2 2 2 4 4 4 0 CpXC protein DUF1713 PF08213.11 ELR12967.1 - 9.2e-11 41.5 22.0 1.4e-10 40.9 22.0 1.3 1 0 0 1 1 1 1 Mitochondrial domain of unknown function (DUF1713) Ras PF00071.22 ELR12968.1 - 3.7e-37 127.4 0.0 5.1e-37 127.0 0.0 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR12968.1 - 9.8e-11 41.9 0.0 1.8e-10 41.1 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase FYVE PF01363.21 ELR12968.1 - 0.0032 17.6 8.2 0.0067 16.5 8.2 1.5 1 0 0 1 1 1 1 FYVE zinc finger GTP_EFTU PF00009.27 ELR12968.1 - 0.004 16.7 0.0 0.0064 16.0 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain FYVE_2 PF02318.16 ELR12968.1 - 0.3 11.3 10.9 0.16 12.2 7.2 2.0 2 0 0 2 2 2 0 FYVE-type zinc finger zf-C3HC4 PF00097.25 ELR12968.1 - 7.9 6.5 12.2 16 5.4 12.2 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Methyltransf_11 PF08241.12 ELR12969.1 - 1.9e-30 105.3 0.0 6.6e-30 103.6 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 ELR12969.1 - 2.9e-27 95.2 0.0 6e-27 94.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ELR12969.1 - 9.2e-23 80.7 0.0 1.3e-22 80.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 ELR12969.1 - 1.1e-20 74.1 0.0 1.5e-20 73.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ELR12969.1 - 5.1e-19 68.8 0.0 9.7e-19 68.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 ELR12969.1 - 1.1e-17 64.2 0.0 1.5e-17 63.7 0.0 1.1 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family CMAS PF02353.20 ELR12969.1 - 6.4e-10 38.8 0.0 8.4e-10 38.4 0.0 1.1 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_4 PF02390.17 ELR12969.1 - 1.5e-09 37.6 0.0 4.9e-07 29.4 0.0 2.1 2 0 0 2 2 2 1 Putative methyltransferase PrmA PF06325.13 ELR12969.1 - 1.5e-07 31.1 0.0 2.1e-07 30.6 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) NodS PF05401.11 ELR12969.1 - 2e-07 30.8 0.0 2.9e-07 30.3 0.0 1.1 1 0 0 1 1 1 1 Nodulation protein S (NodS) Methyltransf_29 PF03141.16 ELR12969.1 - 8.5e-07 27.9 0.0 1.1e-06 27.5 0.0 1.1 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase TPMT PF05724.11 ELR12969.1 - 3.1e-06 27.0 0.0 5.2e-06 26.3 0.0 1.3 1 0 0 1 1 1 1 Thiopurine S-methyltransferase (TPMT) MTS PF05175.14 ELR12969.1 - 3.1e-06 26.8 0.0 4.8e-06 26.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain MetW PF07021.12 ELR12969.1 - 5e-05 23.0 0.0 7.7e-05 22.4 0.0 1.2 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW AdoMet_MTase PF07757.13 ELR12969.1 - 0.00041 20.7 0.0 0.00068 19.9 0.0 1.3 1 0 0 1 1 1 1 Predicted AdoMet-dependent methyltransferase Methyltransf_15 PF09445.10 ELR12969.1 - 0.00082 19.0 0.0 0.0011 18.6 0.0 1.2 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase Methyltransf_18 PF12847.7 ELR12969.1 - 0.0017 18.3 0.0 0.0026 17.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_16 PF10294.9 ELR12969.1 - 0.0065 16.2 0.0 0.016 15.0 0.0 1.6 1 1 0 1 1 1 1 Lysine methyltransferase Methyltransf_2 PF00891.18 ELR12969.1 - 0.0065 15.8 0.0 0.0089 15.3 0.0 1.1 1 0 0 1 1 1 1 O-methyltransferase domain Methyltransf_32 PF13679.6 ELR12969.1 - 0.0068 16.4 0.0 0.01 15.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain UPF0020 PF01170.18 ELR12969.1 - 0.012 15.3 0.0 0.25 11.0 0.0 2.1 2 0 0 2 2 2 0 Putative RNA methylase family UPF0020 Methyltransf_8 PF05148.15 ELR12969.1 - 0.014 15.3 0.0 0.077 12.8 0.0 1.9 1 1 0 1 1 1 0 Hypothetical methyltransferase PCMT PF01135.19 ELR12969.1 - 0.029 14.1 0.0 0.044 13.5 0.0 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) TehB PF03848.14 ELR12969.1 - 0.039 13.4 0.0 0.063 12.7 0.0 1.3 1 0 0 1 1 1 0 Tellurite resistance protein TehB tRNA_U5-meth_tr PF05958.11 ELR12969.1 - 0.04 12.9 0.0 0.058 12.4 0.0 1.1 1 0 0 1 1 1 0 tRNA (Uracil-5-)-methyltransferase Cons_hypoth95 PF03602.15 ELR12969.1 - 0.057 13.1 0.0 0.078 12.6 0.0 1.2 1 0 0 1 1 1 0 Conserved hypothetical protein 95 DREV PF05219.12 ELR12969.1 - 0.07 12.2 0.0 0.099 11.7 0.0 1.2 1 0 0 1 1 1 0 DREV methyltransferase 2OG-FeII_Oxy_2 PF13532.6 ELR12970.1 - 2.6e-18 66.9 0.0 5.9e-18 65.8 0.0 1.6 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily PhyH PF05721.13 ELR12970.1 - 0.0047 17.2 0.0 0.0088 16.3 0.0 1.3 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) Ras PF00071.22 ELR12971.1 - 5.6e-48 162.6 0.0 6.8e-48 162.3 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR12971.1 - 1.1e-31 109.5 0.0 3.1e-31 108.1 0.0 1.6 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR12971.1 - 2.2e-14 53.3 0.1 2.9e-14 52.9 0.1 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 ELR12971.1 - 0.0001 21.9 1.1 0.0013 18.3 0.0 2.2 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 ELR12971.1 - 0.00019 21.5 0.0 0.00034 20.7 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 ELR12971.1 - 0.00041 19.8 0.0 0.00061 19.2 0.0 1.3 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 ELR12971.1 - 0.004 17.1 0.0 2.3 8.1 0.0 2.3 2 0 0 2 2 2 2 RsgA GTPase AAA_7 PF12775.7 ELR12971.1 - 0.026 14.1 0.0 0.045 13.3 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_16 PF13191.6 ELR12971.1 - 0.039 14.3 0.1 0.091 13.1 0.0 1.6 2 0 0 2 2 2 0 AAA ATPase domain AAA PF00004.29 ELR12971.1 - 0.039 14.4 0.0 0.062 13.7 0.0 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_33 PF13671.6 ELR12971.1 - 0.055 13.6 0.1 0.14 12.3 0.1 1.6 2 0 0 2 2 1 0 AAA domain PduV-EutP PF10662.9 ELR12971.1 - 0.062 13.1 0.0 0.15 11.8 0.0 1.6 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation AAA_24 PF13479.6 ELR12971.1 - 0.069 12.9 0.1 0.11 12.2 0.1 1.3 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 ELR12971.1 - 0.082 13.4 0.1 0.3 11.6 0.0 1.8 2 0 0 2 2 2 0 ABC transporter NB-ARC PF00931.22 ELR12971.1 - 0.11 11.7 0.1 0.18 11.0 0.1 1.3 1 0 0 1 1 1 0 NB-ARC domain RE_ScaI PF09569.10 ELR12971.1 - 0.11 12.2 0.0 0.15 11.8 0.0 1.2 1 0 0 1 1 1 0 ScaI restriction endonuclease AAA_22 PF13401.6 ELR12971.1 - 0.11 12.7 0.1 0.35 11.1 0.0 1.8 2 0 0 2 2 2 0 AAA domain NACHT PF05729.12 ELR12971.1 - 0.13 12.1 0.0 0.25 11.3 0.0 1.5 1 0 0 1 1 1 0 NACHT domain TsaE PF02367.17 ELR12971.1 - 0.14 12.1 0.0 0.26 11.3 0.0 1.3 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_5 PF07728.14 ELR12971.1 - 0.15 12.1 0.1 0.26 11.3 0.1 1.4 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_25 PF13481.6 ELR12971.1 - 0.15 11.6 0.0 0.3 10.6 0.0 1.6 1 0 0 1 1 1 0 AAA domain Aminotran_1_2 PF00155.21 ELR12972.1 - 3e-29 102.3 0.0 7.3e-29 101.1 0.0 1.5 1 1 0 1 1 1 1 Aminotransferase class I and II Aminotran_MocR PF12897.7 ELR12972.1 - 3.4e-09 36.0 0.0 1e-08 34.4 0.0 1.5 1 1 0 1 1 1 1 Alanine-glyoxylate amino-transferase Beta_elim_lyase PF01212.21 ELR12972.1 - 0.025 13.9 0.0 0.036 13.4 0.0 1.2 1 0 0 1 1 1 0 Beta-eliminating lyase Aminotran_5 PF00266.19 ELR12972.1 - 0.078 11.9 0.0 4.2 6.2 0.0 2.1 2 0 0 2 2 2 0 Aminotransferase class-V RhoGAP PF00620.27 ELR12973.1 - 3.1e-30 105.0 0.0 5.7e-30 104.1 0.0 1.4 1 0 0 1 1 1 1 RhoGAP domain SAM_1 PF00536.30 ELR12973.1 - 4e-17 62.4 0.0 7.9e-17 61.5 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) C2 PF00168.30 ELR12973.1 - 1.4e-16 60.7 0.0 3.2e-16 59.5 0.0 1.6 1 0 0 1 1 1 1 C2 domain SAM_2 PF07647.17 ELR12973.1 - 1.2e-15 57.3 0.0 2.4e-15 56.4 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_PNT PF02198.16 ELR12973.1 - 7e-07 29.1 0.0 2.2e-06 27.5 0.0 1.8 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain SAM_3 PF18016.1 ELR12973.1 - 0.00065 19.5 0.1 0.0015 18.3 0.1 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Red1 PF07964.11 ELR12974.1 - 0.0096 14.2 6.6 0.011 14.1 6.6 1.0 1 0 0 1 1 1 1 Rec10 / Red1 DUF4569 PF15133.6 ELR12974.1 - 0.37 10.5 5.3 0.51 10.0 5.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4569) DUF3300 PF11737.8 ELR12974.1 - 0.52 9.8 6.6 0.18 11.4 3.6 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF3300) SAPS PF04499.15 ELR12974.1 - 0.53 9.0 7.9 0.65 8.7 7.9 1.0 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Hid1 PF12722.7 ELR12974.1 - 1 7.4 7.0 1.2 7.2 7.0 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Membralin PF09746.9 ELR12974.1 - 3.7 6.5 4.5 4.5 6.2 4.5 1.1 1 0 0 1 1 1 0 Tumour-associated protein MCM_bind PF09739.9 ELR12974.1 - 6.1 5.2 14.3 8.3 4.7 14.3 1.1 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor PH PF00169.29 ELR12975.1 - 1.6e-08 35.0 0.0 4.8e-08 33.5 0.0 1.9 1 0 0 1 1 1 1 PH domain PH_11 PF15413.6 ELR12975.1 - 0.044 14.2 0.0 0.044 14.2 0.0 2.9 3 0 0 3 3 3 0 Pleckstrin homology domain GAPT PF11770.8 ELR12975.1 - 0.22 11.3 0.8 0.47 10.3 0.8 1.4 1 0 0 1 1 1 0 GRB2-binding adapter (GAPT) PTEN_C2 PF10409.9 ELR12976.1 - 1.9e-17 63.3 0.0 3.1e-17 62.6 0.0 1.3 1 0 0 1 1 1 1 C2 domain of PTEN tumour-suppressor protein DSPc PF00782.20 ELR12976.1 - 1.4e-06 28.2 0.0 2.6e-06 27.3 0.0 1.4 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 ELR12976.1 - 1.9e-05 24.4 0.0 3.5e-05 23.5 0.0 1.4 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.6 ELR12976.1 - 0.0011 19.0 0.0 0.0022 18.0 0.0 1.4 1 0 0 1 1 1 1 Tyrosine phosphatase family CDKN3 PF05706.12 ELR12976.1 - 0.052 13.2 0.0 0.089 12.5 0.0 1.4 1 0 0 1 1 1 0 Cyclin-dependent kinase inhibitor 3 (CDKN3) PTPlike_phytase PF14566.6 ELR12976.1 - 0.06 13.5 0.0 0.18 11.9 0.0 1.9 1 0 0 1 1 1 0 Inositol hexakisphosphate SR-25 PF10500.9 ELR12976.1 - 8.2 6.0 31.9 0.07 12.7 15.4 2.5 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein RhoGEF PF00621.20 ELR12977.1 - 1.1e-46 159.3 2.0 2e-46 158.6 2.0 1.4 1 0 0 1 1 1 1 RhoGEF domain PH PF00169.29 ELR12977.1 - 4.7e-08 33.5 0.0 8.7e-08 32.6 0.0 1.5 1 0 0 1 1 1 1 PH domain PH_13 PF16652.5 ELR12977.1 - 4.2e-05 23.4 3.1 0.024 14.4 2.5 2.7 1 1 0 1 1 1 1 Pleckstrin homology domain FYVE PF01363.21 ELR12977.1 - 0.0026 17.8 0.6 0.0056 16.8 0.6 1.6 1 0 0 1 1 1 1 FYVE zinc finger PH_3 PF14593.6 ELR12977.1 - 0.034 14.2 0.1 0.072 13.2 0.1 1.5 1 0 0 1 1 1 0 PH domain Rsd_AlgQ PF04353.13 ELR12977.1 - 0.059 13.3 0.1 0.14 12.1 0.1 1.5 1 0 0 1 1 1 0 Regulator of RNA polymerase sigma(70) subunit, Rsd/AlgQ TauE PF01925.19 ELR12978.1 - 8.4e-21 74.7 12.3 8.4e-21 74.7 12.3 1.8 1 1 0 1 1 1 1 Sulfite exporter TauE/SafE UPF0767 PF15990.5 ELR12978.1 - 0.22 11.7 0.0 0.51 10.5 0.0 1.5 1 0 0 1 1 1 0 UPF0767 family DUF3093 PF11292.8 ELR12978.1 - 1.1 9.5 4.3 3.3 8.0 4.3 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3093) p450 PF00067.22 ELR12979.1 - 8e-28 97.4 0.0 2.3e-27 95.9 0.0 1.6 1 1 0 1 1 1 1 Cytochrome P450 p450 PF00067.22 ELR12981.1 - 1.5e-24 86.6 0.0 2.7e-24 85.8 0.0 1.3 1 1 0 1 1 1 1 Cytochrome P450 PPR_2 PF13041.6 ELR12983.1 - 5.9e-38 128.8 2.1 7.9e-10 38.8 0.0 6.9 4 3 4 8 8 8 6 PPR repeat family PPR_3 PF13812.6 ELR12983.1 - 3.1e-28 97.6 0.6 1.2e-05 25.3 0.0 6.4 6 1 0 6 6 6 5 Pentatricopeptide repeat domain PPR_long PF17177.4 ELR12983.1 - 1.9e-16 60.1 0.7 1.7e-07 30.9 0.0 3.3 2 1 1 3 3 3 3 Pentacotripeptide-repeat region of PRORP PPR PF01535.20 ELR12983.1 - 6.7e-15 54.2 7.7 0.0078 16.4 0.0 8.3 9 0 0 9 9 9 3 PPR repeat PPR_1 PF12854.7 ELR12983.1 - 3.2e-08 33.1 4.2 4.1 7.2 0.0 7.8 9 0 0 9 9 9 2 PPR repeat BTAD PF03704.17 ELR12983.1 - 0.013 15.9 3.4 0.3 11.5 0.0 3.8 4 0 0 4 4 4 0 Bacterial transcriptional activator domain TPR_2 PF07719.17 ELR12983.1 - 0.02 15.0 1.6 0.68 10.2 0.0 3.0 2 0 0 2 2 2 0 Tetratricopeptide repeat LRR_6 PF13516.6 ELR12984.1 - 2.1e-17 61.6 7.1 0.043 13.9 0.1 10.4 11 0 0 11 11 11 4 Leucine Rich repeat LRR_4 PF12799.7 ELR12984.1 - 2e-13 50.2 3.3 0.014 15.8 0.0 8.3 9 0 0 9 9 9 3 Leucine Rich repeats (2 copies) Regnase_1_C PF18561.1 ELR12984.1 - 0.095 12.4 0.2 16 5.4 0.0 2.9 3 0 0 3 3 3 0 Endoribonuclease Regnase 1/ ZC3H12 C-terminal domain LRR_1 PF00560.33 ELR12984.1 - 0.22 12.2 10.1 2e+02 3.2 0.0 7.6 8 0 0 8 8 8 0 Leucine Rich Repeat Radical_SAM PF04055.21 ELR12985.1 - 8.4e-17 62.0 0.6 2.9e-16 60.3 0.6 1.9 1 1 0 1 1 1 1 Radical SAM superfamily HemN_C PF06969.16 ELR12985.1 - 1.2e-11 44.5 0.1 3.1e-11 43.2 0.1 1.7 1 0 0 1 1 1 1 HemN C-terminal domain RhoGAP PF00620.27 ELR12986.1 - 2.1e-39 134.8 0.1 3.5e-39 134.1 0.1 1.3 1 0 0 1 1 1 1 RhoGAP domain PH PF00169.29 ELR12986.1 - 3.1e-05 24.4 0.0 5.2e-05 23.7 0.0 1.4 1 0 0 1 1 1 1 PH domain Usp PF00582.26 ELR12987.1 - 5.2e-26 91.8 0.0 7e-26 91.4 0.0 1.2 1 0 0 1 1 1 1 Universal stress protein family UCH PF00443.29 ELR12988.1 - 8.6e-15 54.9 0.0 1.3e-14 54.4 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 ELR12988.1 - 5.5e-08 32.8 0.0 7.4e-05 22.5 0.0 2.2 2 0 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase CUE PF02845.16 ELR12988.1 - 2e-05 24.2 0.0 5.9e-05 22.7 0.0 1.8 2 0 0 2 2 2 1 CUE domain USP7_C2 PF14533.6 ELR12988.1 - 0.0023 17.7 0.0 0.0038 16.9 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-specific protease C-terminal CIAPIN1 PF05093.13 ELR12988.1 - 0.11 13.0 0.1 0.28 11.7 0.1 1.6 1 0 0 1 1 1 0 Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis GATA PF00320.27 ELR12989.1 - 6.8e-06 25.6 5.0 1.2e-05 24.7 5.0 1.4 1 0 0 1 1 1 1 GATA zinc finger MutL_C PF08676.11 ELR12989.1 - 0.041 13.6 0.0 0.05 13.4 0.0 1.1 1 0 0 1 1 1 0 MutL C terminal dimerisation domain GATA PF00320.27 ELR12990.1 - 9.9e-13 47.5 3.9 2.4e-12 46.3 3.9 1.7 1 0 0 1 1 1 1 GATA zinc finger bPH_5 PF10882.8 ELR12990.1 - 0.028 14.5 0.1 0.066 13.3 0.0 1.6 2 0 0 2 2 2 0 Bacterial PH domain P33MONOX PF15302.6 ELR12990.1 - 0.07 12.8 0.5 0.093 12.4 0.5 1.2 1 0 0 1 1 1 0 P33 mono-oxygenase DUF1677 PF07911.13 ELR12990.1 - 0.083 13.3 1.8 0.14 12.5 0.2 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1677) SR-25 PF10500.9 ELR12990.1 - 0.15 11.6 4.7 0.048 13.3 1.9 1.5 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein Zn-ribbon_8 PF09723.10 ELR12990.1 - 0.17 12.0 0.3 0.34 11.1 0.3 1.5 1 0 0 1 1 1 0 Zinc ribbon domain zf-NADH-PPase PF09297.11 ELR12990.1 - 0.21 11.3 7.4 2.5 7.9 0.8 2.8 3 0 0 3 3 3 0 NADH pyrophosphatase zinc ribbon domain RasGAP PF00616.19 ELR12991.1 - 2.6e-28 99.2 0.1 3.1e-22 79.3 0.1 7.3 2 2 1 4 4 4 2 GTPase-activator protein for Ras-like GTPase DEP PF00610.21 ELR12991.1 - 3.2e-14 52.7 0.2 1.7e-13 50.4 0.0 2.3 2 0 0 2 2 2 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) Mitofilin PF09731.9 ELR12992.1 - 0.036 12.9 10.4 0.043 12.7 10.4 1.1 1 0 0 1 1 1 0 Mitochondrial inner membrane protein Macoilin PF09726.9 ELR12992.1 - 0.68 8.4 19.5 0.89 8.0 19.5 1.0 1 0 0 1 1 1 0 Macoilin family Apt1 PF10351.9 ELR12992.1 - 2.7 6.7 14.1 4.6 6.0 14.1 1.4 1 0 0 1 1 1 0 Golgi-body localisation protein domain ubiquitin PF00240.23 ELR12993.1 - 6.2e-102 333.4 14.4 2.7e-34 116.8 0.7 3.0 2 1 1 3 3 3 3 Ubiquitin family Rad60-SLD PF11976.8 ELR12993.1 - 3.7e-49 164.4 13.9 2.1e-16 59.5 0.8 3.0 2 1 1 3 3 3 3 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 ELR12993.1 - 2.7e-19 69.4 6.6 5.8e-05 23.5 0.2 4.6 2 2 1 3 3 3 3 Ubiquitin-like domain TBK1_ULD PF18396.1 ELR12993.1 - 2.8e-13 49.6 1.3 0.0082 16.0 0.1 3.3 2 1 1 3 3 3 3 TANK binding kinase 1 ubiquitin-like domain DUF2407 PF10302.9 ELR12993.1 - 3.2e-12 46.9 0.5 0.036 14.6 0.0 3.1 1 1 1 3 3 3 3 DUF2407 ubiquitin-like domain Rad60-SLD_2 PF13881.6 ELR12993.1 - 1.3e-11 44.6 2.1 0.034 14.3 0.1 4.0 2 2 1 3 3 3 3 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_5 PF18037.1 ELR12993.1 - 3.6e-11 43.3 5.6 0.014 15.7 0.1 3.1 1 1 2 3 3 3 3 Ubiquitin-like domain DUF3861 PF12977.7 ELR12993.1 - 4.6e-06 26.7 1.6 2.6 8.3 0.1 3.2 3 0 0 3 3 3 3 Domain of Unknown Function with PDB structure (DUF3861) Ubiquitin_4 PF18036.1 ELR12993.1 - 7.9e-06 25.8 16.7 4.7 7.3 0.2 6.0 5 1 1 6 6 6 2 Ubiquitin-like domain Sde2_N_Ubi PF13019.6 ELR12993.1 - 3.3e-05 23.8 0.2 0.95 9.3 0.0 3.1 2 1 1 3 3 3 2 Silencing defective 2 N-terminal ubiquitin domain DUF2870 PF11069.8 ELR12993.1 - 0.0012 19.1 0.0 31 5.0 0.0 3.6 3 0 0 3 3 3 0 Protein of unknown function (DUF2870) Raf1_HTH PF18579.1 ELR12993.1 - 0.0019 17.9 0.5 24 4.7 0.0 3.3 3 0 0 3 3 3 0 Rubisco accumulation factor 1 helix turn helix domain Big_3_3 PF13750.6 ELR12993.1 - 0.0021 17.7 0.2 6.3 6.4 0.1 3.1 2 1 1 3 3 3 0 Bacterial Ig-like domain (group 3) ACT_5 PF13710.6 ELR12993.1 - 0.0035 17.2 3.8 12 5.8 0.1 3.3 3 0 0 3 3 3 0 ACT domain ACT_4 PF13291.6 ELR12993.1 - 0.0044 17.6 0.9 38 5.0 0.1 3.3 3 0 0 3 3 3 0 ACT domain DUF493 PF04359.14 ELR12993.1 - 0.0051 17.4 0.1 48 4.6 0.0 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF493) Plexin_cytopl PF08337.12 ELR12993.1 - 0.0057 15.4 10.6 0.46 9.1 0.2 4.0 4 1 1 5 5 5 2 Plexin cytoplasmic RasGAP domain Big_7 PF17957.1 ELR12993.1 - 0.0065 17.2 0.0 60 4.5 0.0 3.1 3 0 0 3 3 3 0 Bacterial Ig domain DUF1866 PF08952.11 ELR12993.1 - 0.007 16.2 0.3 32 4.3 0.0 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF1866) RBD PF02196.15 ELR12993.1 - 0.0095 16.0 0.0 51 4.1 0.0 3.3 3 0 0 3 3 3 0 Raf-like Ras-binding domain ProRS-C_2 PF09181.10 ELR12993.1 - 0.041 14.0 3.7 39 4.5 0.1 3.2 3 0 0 3 3 3 0 Prolyl-tRNA synthetase, C-terminal UDP-g_GGTase PF06427.11 ELR12993.1 - 0.048 13.8 2.5 2.9 8.0 0.1 3.2 3 0 0 3 3 3 0 UDP-glucose:Glycoprotein Glucosyltransferase Coagulin PF02035.15 ELR12993.1 - 0.052 13.4 1.7 38 4.1 0.0 3.1 3 0 0 3 3 3 0 Coagulin Acp26Ab PF05777.12 ELR12993.1 - 0.072 13.7 2.4 6.6 7.4 0.0 4.0 4 1 0 4 4 4 0 Drosophila accessory gland-specific peptide 26Ab (Acp26Ab) YukD PF08817.10 ELR12993.1 - 0.088 13.5 0.1 1.3e+02 3.4 0.0 3.2 3 0 0 3 3 3 0 WXG100 protein secretion system (Wss), protein YukD PI3K_p85B PF02192.16 ELR12993.1 - 0.1 12.3 7.0 20 5.0 0.2 3.3 3 0 0 3 3 3 0 PI3-kinase family, p85-binding domain Tash_PEST PF07708.11 ELR12993.1 - 0.12 12.6 18.4 4.3 7.6 1.5 3.3 3 0 0 3 3 3 0 Tash protein PEST motif Phage_sheath_1N PF17481.2 ELR12993.1 - 0.23 11.9 4.0 83 3.7 4.0 3.0 1 1 0 1 1 1 0 Phage tail sheath protein beta-sandwich domain Myosin_N PF02736.19 ELR12993.1 - 1.4 8.8 4.1 72 3.3 0.0 3.9 3 0 0 3 3 3 0 Myosin N-terminal SH3-like domain Helicase_C PF00271.31 ELR12994.1 - 1.3e-24 86.6 0.0 3.4e-24 85.3 0.0 1.7 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 ELR12994.1 - 6e-20 71.7 0.0 8.2e-12 45.2 0.1 2.3 2 0 0 2 2 2 2 DEAD/DEAH box helicase DUF3742 PF12553.8 ELR12994.1 - 0.023 14.8 0.0 0.13 12.4 0.0 2.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3742) PUCC PF03209.15 ELR12994.1 - 0.1 11.6 0.2 0.42 9.6 0.0 1.8 2 0 0 2 2 2 0 PUCC protein Aldo_ket_red PF00248.21 ELR12995.1 - 9.4e-75 251.5 0.0 1.1e-74 251.3 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Pkinase PF00069.25 ELR12996.1 - 1.3e-51 175.5 0.0 2.5e-51 174.6 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR12996.1 - 1.6e-50 171.8 0.0 2.7e-50 171.1 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ELR12996.1 - 0.015 14.7 0.1 0.042 13.2 0.0 1.7 2 0 0 2 2 2 0 Kinase-like DASH_Hsk3 PF08227.11 ELR12996.1 - 0.094 13.1 2.6 0.21 12.0 2.1 1.9 2 0 0 2 2 2 0 DASH complex subunit Hsk3 like Thymosin PF01290.20 ELR12996.1 - 0.14 11.9 2.6 0.27 11.0 0.1 2.6 2 0 0 2 2 2 0 Thymosin beta-4 family CxC7 PF18866.1 ELR12997.1 - 0.13 12.4 1.9 0.26 11.4 0.1 2.1 2 0 0 2 2 2 0 CxC7 like cysteine cluster associated with KDZ transposases Kinesin PF00225.23 ELR12998.1 - 2e-87 293.2 0.0 2.6e-87 292.9 0.0 1.1 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 ELR12998.1 - 5.5e-16 58.9 0.0 9.3e-16 58.1 0.0 1.3 1 0 0 1 1 1 1 Microtubule binding PAC3 PF10178.9 ELR12998.1 - 0.19 11.9 0.0 0.88 9.8 0.0 2.2 2 0 0 2 2 2 0 Proteasome assembly chaperone 3 AAA_16 PF13191.6 ELR12998.1 - 7.3 6.9 7.6 0.26 11.6 0.1 2.5 3 1 0 3 3 3 0 AAA ATPase domain Pkinase PF00069.25 ELR12999.1 - 8.5e-05 22.0 0.2 0.037 13.4 0.0 2.6 3 0 0 3 3 3 2 Protein kinase domain Pkinase_fungal PF17667.1 ELR12999.1 - 0.0022 16.8 0.0 0.0035 16.2 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase FYVE PF01363.21 ELR13000.1 - 1.1e-09 38.2 15.4 1.1e-09 38.2 15.4 2.7 2 1 0 2 2 2 1 FYVE zinc finger zf-RING_UBOX PF13445.6 ELR13000.1 - 4.3e-05 23.4 0.5 4.3e-05 23.4 0.5 3.6 4 1 0 4 4 4 1 RING-type zinc-finger zf-RING_5 PF14634.6 ELR13000.1 - 0.00048 20.0 0.7 0.00048 20.0 0.7 3.6 3 0 0 3 3 3 1 zinc-RING finger domain zf-C3HC4 PF00097.25 ELR13000.1 - 0.0021 17.9 1.4 0.0021 17.9 1.4 3.5 4 1 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 ELR13000.1 - 0.0059 16.7 1.2 0.0059 16.7 1.2 3.6 3 0 0 3 3 3 1 zinc finger of C3HC4-type, RING zf-RING_2 PF13639.6 ELR13000.1 - 0.02 15.2 0.6 0.02 15.2 0.6 4.0 3 1 0 3 3 3 0 Ring finger domain zf-C3HC4_2 PF13923.6 ELR13000.1 - 0.022 14.6 1.4 0.022 14.6 1.4 3.6 4 0 0 4 4 4 0 Zinc finger, C3HC4 type (RING finger) PGA2 PF07543.12 ELR13000.1 - 3 7.8 10.4 2.4 8.1 4.4 2.3 2 0 0 2 2 2 0 Protein trafficking PGA2 Polyketide_cyc PF03364.20 ELR13001.1 - 6.1e-21 75.0 0.0 8.3e-21 74.6 0.0 1.2 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport Polyketide_cyc2 PF10604.9 ELR13001.1 - 0.00042 20.6 0.0 0.00089 19.5 0.0 1.5 1 1 1 2 2 2 1 Polyketide cyclase / dehydrase and lipid transport Steroid_dh PF02544.16 ELR13003.1 - 2.2e-20 73.2 0.5 4.9e-17 62.3 0.1 2.4 2 1 0 2 2 2 2 3-oxo-5-alpha-steroid 4-dehydrogenase ERG4_ERG24 PF01222.17 ELR13003.1 - 0.019 13.8 0.3 0.03 13.1 0.3 1.4 1 0 0 1 1 1 0 Ergosterol biosynthesis ERG4/ERG24 family PEMT PF04191.13 ELR13003.1 - 0.027 14.8 0.2 0.027 14.8 0.2 2.3 4 0 0 4 4 4 0 Phospholipid methyltransferase Stonin2_N PF12016.8 ELR13003.1 - 2.2 7.6 6.7 3.1 7.1 6.7 1.1 1 0 0 1 1 1 0 Stonin 2 NIF3 PF01784.18 ELR13004.1 - 1.7e-35 122.8 0.0 2.1e-35 122.5 0.0 1.1 1 0 0 1 1 1 1 NIF3 (NGG1p interacting factor 3) NIF3 PF01784.18 ELR13005.1 - 2.3e-31 109.3 0.0 2.7e-31 109.1 0.0 1.0 1 0 0 1 1 1 1 NIF3 (NGG1p interacting factor 3) CutA1 PF03091.15 ELR13005.1 - 0.0039 17.0 0.0 0.0092 15.8 0.0 1.6 1 0 0 1 1 1 1 CutA1 divalent ion tolerance protein Morc6_S5 PF17942.1 ELR13006.1 - 4.1e-44 150.0 0.1 8.5e-44 149.0 0.1 1.6 1 0 0 1 1 1 1 Morc6 ribosomal protein S5 domain 2-like HATPase_c_3 PF13589.6 ELR13006.1 - 7.2e-11 42.1 0.0 1.7e-10 40.9 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase zf-CW PF07496.15 ELR13006.1 - 0.00052 20.0 0.8 0.0011 19.0 0.8 1.5 1 0 0 1 1 1 1 CW-type Zinc Finger BLOC1_2 PF10046.9 ELR13007.1 - 0.0042 17.3 1.5 0.0042 17.3 1.5 1.7 2 0 0 2 2 2 1 Biogenesis of lysosome-related organelles complex-1 subunit 2 Atg14 PF10186.9 ELR13007.1 - 0.01 15.0 2.7 0.01 15.0 2.7 2.0 2 1 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF3552 PF12072.8 ELR13007.1 - 0.78 9.1 17.3 0.021 14.3 6.3 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF3552) DivIC PF04977.15 ELR13007.1 - 0.97 9.3 7.3 3.7 7.4 7.3 2.0 1 0 0 1 1 1 0 Septum formation initiator IU_nuc_hydro PF01156.19 ELR13008.1 - 5.6e-72 242.9 0.0 6.8e-72 242.6 0.0 1.0 1 0 0 1 1 1 1 Inosine-uridine preferring nucleoside hydrolase MARVEL PF01284.23 ELR13009.1 - 0.061 13.4 10.8 0.092 12.8 10.8 1.3 1 0 0 1 1 1 0 Membrane-associating domain Tetraspanin PF00335.20 ELR13009.1 - 1.6 8.4 9.4 2.6 7.7 4.9 2.2 1 1 1 2 2 2 0 Tetraspanin family FAT PF02259.23 ELR13010.1 - 6.7e-109 364.3 0.0 4.2e-108 361.6 0.0 2.5 1 1 0 1 1 1 1 FAT domain PI3_PI4_kinase PF00454.27 ELR13010.1 - 1.2e-51 176.0 0.2 3.2e-51 174.5 0.0 1.8 2 0 0 2 2 1 1 Phosphatidylinositol 3- and 4-kinase DUF3385 PF11865.8 ELR13010.1 - 5.7e-47 159.6 7.3 2.1e-40 138.2 0.5 5.7 4 1 0 4 4 4 2 Domain of unknown function (DUF3385) FRB_dom PF08771.11 ELR13010.1 - 3.6e-44 149.2 0.6 3.6e-44 149.2 0.6 3.3 3 0 0 3 3 2 1 FKBP12-rapamycin binding domain HEAT PF02985.22 ELR13010.1 - 5.5e-22 76.0 19.4 0.0015 18.6 0.0 12.8 12 0 0 12 12 12 5 HEAT repeat HEAT_2 PF13646.6 ELR13010.1 - 8.8e-18 64.5 19.7 0.057 13.8 0.0 10.4 7 2 2 9 9 9 5 HEAT repeats FATC PF02260.20 ELR13010.1 - 4.5e-17 61.6 2.2 1e-16 60.4 2.2 1.7 1 0 0 1 1 1 1 FATC domain HEAT_EZ PF13513.6 ELR13010.1 - 3.4e-13 49.8 18.2 0.0013 19.2 0.1 10.9 11 1 1 12 12 12 3 HEAT-like repeat Cnd1 PF12717.7 ELR13010.1 - 4.3e-13 49.6 6.1 0.27 11.2 0.0 7.1 3 2 4 7 7 7 4 non-SMC mitotic condensation complex subunit 1 CLASP_N PF12348.8 ELR13010.1 - 1.5e-07 31.2 6.6 0.49 9.9 0.2 6.1 5 2 1 6 6 6 3 CLASP N terminal ParcG PF10274.9 ELR13010.1 - 3.5e-06 27.2 12.1 0.23 11.5 0.1 6.3 4 3 2 6 6 6 2 Parkin co-regulated protein Sec7_N PF12783.7 ELR13010.1 - 5.2e-06 26.4 1.5 0.076 12.9 0.0 4.1 3 0 0 3 3 3 2 Guanine nucleotide exchange factor in Golgi transport N-terminal Vac14_Fab1_bd PF12755.7 ELR13010.1 - 6.6e-06 26.6 0.0 19 5.9 0.0 5.9 4 1 1 5 5 5 0 Vacuolar 14 Fab1-binding region RTP1_C1 PF10363.9 ELR13010.1 - 1.4e-05 25.2 3.9 3.4 7.9 0.0 6.6 5 1 1 6 6 6 1 Required for nuclear transport of RNA pol II C-terminus 1 MMS19_C PF12460.8 ELR13010.1 - 4.3e-05 22.8 6.9 0.03 13.5 0.3 4.5 3 1 1 4 4 4 2 RNAPII transcription regulator C-terminal UME PF08064.13 ELR13010.1 - 0.00016 21.5 6.8 0.28 11.1 0.1 5.7 6 0 0 6 6 4 2 UME (NUC010) domain TPR_19 PF14559.6 ELR13010.1 - 0.052 14.1 1.5 23 5.6 0.0 4.4 3 0 0 3 3 3 0 Tetratricopeptide repeat Peptidase_M41 PF01434.18 ELR13010.1 - 0.1 12.5 1.4 0.73 9.6 1.4 2.6 1 0 0 1 1 1 0 Peptidase family M41 DUF3730 PF12530.8 ELR13010.1 - 0.14 11.7 0.0 0.14 11.7 0.0 4.0 6 0 0 6 6 5 0 Protein of unknown function (DUF3730) TPR_7 PF13176.6 ELR13010.1 - 0.16 12.1 0.8 1.8 8.7 0.2 3.2 2 0 0 2 2 2 0 Tetratricopeptide repeat Cohesin_HEAT PF12765.7 ELR13010.1 - 0.61 10.5 6.6 4.9 7.5 0.0 4.5 5 0 0 5 5 4 0 HEAT repeat associated with sister chromatid cohesion ANAPC3 PF12895.7 ELR13010.1 - 0.73 10.1 5.5 3.4 8.0 0.1 4.2 4 0 0 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_2 PF07719.17 ELR13010.1 - 4.5 7.6 8.8 35 4.8 0.0 4.8 5 0 0 5 5 3 0 Tetratricopeptide repeat RRM_1 PF00076.22 ELR13012.1 - 1.3e-12 47.3 0.1 4.6e-07 29.6 0.1 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-RanBP PF00641.18 ELR13012.1 - 5.5e-06 25.6 7.1 8.6e-06 25.0 7.1 1.3 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others RIO1 PF01163.22 ELR13013.1 - 0.00012 21.7 0.0 0.00033 20.3 0.0 1.7 1 0 0 1 1 1 1 RIO1 family Pkinase PF00069.25 ELR13013.1 - 0.00019 20.9 0.0 0.028 13.8 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_fungal PF17667.1 ELR13013.1 - 0.00028 19.8 0.0 0.00043 19.2 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase FAD_binding_6 PF00970.24 ELR13014.1 - 1.1e-28 99.4 0.0 1.9e-28 98.7 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_1 PF00175.21 ELR13014.1 - 6.2e-24 84.7 0.0 1.4e-23 83.6 0.0 1.6 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain NAD_binding_6 PF08030.12 ELR13014.1 - 0.00022 21.4 0.0 0.0021 18.2 0.0 2.0 1 1 1 2 2 2 1 Ferric reductase NAD binding domain Phage_Coat_B PF05356.11 ELR13014.1 - 0.15 12.0 0.1 0.4 10.6 0.1 1.7 1 0 0 1 1 1 0 Phage Coat protein B AAA PF00004.29 ELR13016.1 - 7.5e-54 181.7 0.0 4.6e-40 137.1 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) PEX-1N PF09262.11 ELR13016.1 - 2.6e-24 85.4 0.7 6.1e-24 84.2 0.7 1.7 1 0 0 1 1 1 1 Peroxisome biogenesis factor 1, N-terminal AAA_16 PF13191.6 ELR13016.1 - 3.2e-14 53.7 1.0 0.00018 21.9 0.0 5.0 3 2 1 4 4 3 2 AAA ATPase domain AAA_lid_3 PF17862.1 ELR13016.1 - 2.1e-13 49.8 0.3 3e-07 30.1 0.0 2.6 2 0 0 2 2 2 2 AAA+ lid domain AAA_33 PF13671.6 ELR13016.1 - 1.2e-08 35.3 0.1 0.0064 16.7 0.1 2.7 2 1 0 2 2 2 2 AAA domain AAA_22 PF13401.6 ELR13016.1 - 2.1e-08 34.6 0.6 0.051 13.9 0.1 4.6 2 2 1 3 3 3 2 AAA domain NACHT PF05729.12 ELR13016.1 - 3.9e-08 33.4 0.5 0.00029 20.8 0.1 3.2 2 2 0 2 2 2 2 NACHT domain AAA_5 PF07728.14 ELR13016.1 - 5e-08 33.0 0.0 0.0083 16.1 0.0 2.9 2 1 0 2 2 2 2 AAA domain (dynein-related subfamily) IstB_IS21 PF01695.17 ELR13016.1 - 2e-07 30.9 0.0 0.021 14.6 0.0 2.4 2 0 0 2 2 2 2 IstB-like ATP binding protein AAA_18 PF13238.6 ELR13016.1 - 2.8e-07 31.1 0.0 0.015 15.8 0.0 2.6 2 0 0 2 2 2 2 AAA domain Bac_DnaA PF00308.18 ELR13016.1 - 5.8e-07 29.6 0.0 0.028 14.2 0.0 3.2 3 0 0 3 3 3 1 Bacterial dnaA protein RNA_helicase PF00910.22 ELR13016.1 - 1.4e-06 28.6 0.0 0.07 13.5 0.0 2.7 2 0 0 2 2 2 2 RNA helicase AAA_25 PF13481.6 ELR13016.1 - 1.6e-06 27.8 2.6 0.2 11.2 0.2 4.3 2 2 1 4 4 4 2 AAA domain RuvB_N PF05496.12 ELR13016.1 - 4.5e-06 26.5 0.0 0.0091 15.8 0.0 2.6 2 0 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_14 PF13173.6 ELR13016.1 - 1.1e-05 25.4 0.0 0.013 15.5 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_17 PF13207.6 ELR13016.1 - 1.4e-05 25.5 0.0 0.14 12.6 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_2 PF07724.14 ELR13016.1 - 2.5e-05 24.4 0.0 0.0026 17.9 0.0 3.4 3 0 0 3 3 3 1 AAA domain (Cdc48 subfamily) TsaE PF02367.17 ELR13016.1 - 6.5e-05 22.9 0.0 0.43 10.6 0.0 2.4 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE NB-ARC PF00931.22 ELR13016.1 - 9.4e-05 21.7 0.0 0.16 11.1 0.0 2.5 2 0 0 2 2 2 2 NB-ARC domain AAA_28 PF13521.6 ELR13016.1 - 0.00016 22.0 0.0 1.1 9.4 0.0 3.0 3 0 0 3 3 2 2 AAA domain Rad17 PF03215.15 ELR13016.1 - 0.00028 20.9 0.1 0.62 9.9 0.0 2.5 2 0 0 2 2 2 2 Rad17 P-loop domain ABC_tran PF00005.27 ELR13016.1 - 0.00028 21.4 0.0 0.3 11.6 0.0 2.8 2 0 0 2 2 2 1 ABC transporter Mg_chelatase PF01078.21 ELR13016.1 - 0.00052 19.5 0.5 0.086 12.2 0.1 2.6 3 0 0 3 3 2 1 Magnesium chelatase, subunit ChlI AAA_7 PF12775.7 ELR13016.1 - 0.0018 17.8 0.0 2.5 7.6 0.0 2.7 3 0 0 3 3 2 2 P-loop containing dynein motor region Viral_helicase1 PF01443.18 ELR13016.1 - 0.0026 17.6 0.0 0.94 9.2 0.0 2.4 2 0 0 2 2 2 1 Viral (Superfamily 1) RNA helicase AAA_29 PF13555.6 ELR13016.1 - 0.0026 17.5 0.0 0.38 10.5 0.0 2.6 2 0 0 2 2 2 1 P-loop containing region of AAA domain Zeta_toxin PF06414.12 ELR13016.1 - 0.0048 16.2 0.0 1.8 7.8 0.0 2.6 2 0 0 2 2 2 1 Zeta toxin TIP49 PF06068.13 ELR13016.1 - 0.011 15.0 0.0 1 8.5 0.0 2.2 2 0 0 2 2 2 0 TIP49 P-loop domain Sigma54_activat PF00158.26 ELR13016.1 - 0.011 15.4 0.0 6.4 6.5 0.0 3.0 3 0 0 3 3 3 0 Sigma-54 interaction domain SKI PF01202.22 ELR13016.1 - 0.014 15.6 0.0 4.8 7.3 0.0 2.7 2 0 0 2 2 2 0 Shikimate kinase AAA_24 PF13479.6 ELR13016.1 - 0.015 15.1 0.0 2.3 7.9 0.0 2.3 2 0 0 2 2 2 0 AAA domain DUF815 PF05673.13 ELR13016.1 - 0.016 14.4 0.0 0.26 10.4 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF815) ATPase_2 PF01637.18 ELR13016.1 - 0.018 14.9 0.0 4.8 7.0 0.0 3.0 3 0 0 3 3 3 0 ATPase domain predominantly from Archaea PhoH PF02562.16 ELR13016.1 - 0.022 14.2 0.0 0.53 9.7 0.0 2.4 2 0 0 2 2 2 0 PhoH-like protein PduV-EutP PF10662.9 ELR13016.1 - 0.041 13.6 0.1 2.8 7.7 0.0 2.4 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_23 PF13476.6 ELR13016.1 - 0.065 13.7 0.0 1 9.8 0.0 2.4 2 0 0 2 2 2 0 AAA domain Parvo_NS1 PF01057.17 ELR13016.1 - 0.065 12.3 0.0 2 7.5 0.0 2.7 3 0 0 3 3 3 0 Parvovirus non-structural protein NS1 ATPase PF06745.13 ELR13016.1 - 0.083 12.2 0.9 16 4.8 0.0 3.7 4 0 0 4 4 4 0 KaiC CPT PF07931.12 ELR13016.1 - 0.13 12.1 0.0 0.5 10.2 0.0 2.1 2 0 0 2 2 2 0 Chloramphenicol phosphotransferase-like protein AAA_3 PF07726.11 ELR13016.1 - 0.15 11.9 0.0 7.4 6.4 0.0 2.4 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Ribosomal_S4e PF00900.20 ELR13017.1 - 3.8e-36 122.8 0.4 9e-36 121.6 0.4 1.7 1 0 0 1 1 1 1 Ribosomal family S4e 40S_S4_C PF16121.5 ELR13017.1 - 2.4e-21 75.1 0.1 4.5e-21 74.2 0.1 1.5 1 0 0 1 1 1 1 40S ribosomal protein S4 C-terminus S4 PF01479.25 ELR13017.1 - 2.1e-08 33.7 0.0 4.7e-08 32.6 0.0 1.7 1 0 0 1 1 1 1 S4 domain RS4NT PF08071.12 ELR13017.1 - 7e-06 26.1 1.0 1.6e-05 24.9 1.0 1.7 1 0 0 1 1 1 1 RS4NT (NUC023) domain KOW PF00467.29 ELR13017.1 - 0.021 14.7 0.8 0.19 11.7 0.0 3.0 3 0 0 3 3 3 0 KOW motif PQQ_2 PF13360.6 ELR13018.1 - 0.0073 15.9 0.1 0.018 14.6 0.1 1.6 1 1 0 1 1 1 1 PQQ-like domain TonB_2 PF13103.6 ELR13018.1 - 0.094 13.0 0.0 0.22 11.8 0.0 1.5 1 0 0 1 1 1 0 TonB C terminal DNA_pol_E_B PF04042.16 ELR13019.1 - 6.8e-34 117.1 0.0 2.8e-33 115.1 0.0 1.9 1 1 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B Dpoe2NT PF12213.8 ELR13019.1 - 0.0019 18.5 0.1 0.0041 17.4 0.1 1.5 1 0 0 1 1 1 1 DNA polymerases epsilon N terminal WRNPLPNID PF15017.6 ELR13019.1 - 0.02 15.7 1.0 0.15 13.0 1.3 2.1 2 0 0 2 2 2 0 Putative WW-binding domain and destruction box Mito_carr PF00153.27 ELR13020.1 - 8.1e-66 218.0 0.7 1.4e-24 85.8 0.0 3.2 2 1 1 3 3 3 3 Mitochondrial carrier protein DUF5075 PF16825.5 ELR13020.1 - 0.12 12.0 0.9 0.47 10.1 0.1 2.3 3 0 0 3 3 3 0 IGP family C-type lectin domain Kelch_3 PF13415.6 ELR13020.1 - 1.1 9.6 3.4 2.1 8.7 0.2 3.0 4 0 0 4 4 4 0 Galactose oxidase, central domain Hyd_WA PF06462.12 ELR13020.1 - 7.9 6.6 8.4 49 4.1 0.1 4.5 4 1 0 4 4 4 0 Propeller zf-DNL PF05180.12 ELR13022.1 - 2e-26 91.7 0.1 3e-26 91.1 0.1 1.3 1 0 0 1 1 1 1 DNL zinc finger DUF3834 PF12916.7 ELR13022.1 - 0.15 11.3 0.0 0.21 10.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3834) Acetyltransf_10 PF13673.7 ELR13024.1 - 9.5e-11 41.7 0.0 2.1e-10 40.6 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 ELR13024.1 - 1.6e-10 41.3 0.0 4.3e-10 39.9 0.0 1.8 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 ELR13024.1 - 3.2e-09 37.0 0.0 7.4e-09 35.9 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family FR47 PF08445.10 ELR13024.1 - 8.2e-05 22.5 0.0 0.00031 20.6 0.0 1.8 2 0 0 2 2 2 1 FR47-like protein GNAT_acetyltran PF12746.7 ELR13024.1 - 0.00035 20.2 0.0 0.00052 19.7 0.0 1.2 1 0 0 1 1 1 1 GNAT acetyltransferase Acetyltransf_9 PF13527.7 ELR13024.1 - 0.0015 18.6 0.3 0.0047 17.0 0.0 1.9 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain RBR PF17208.3 ELR13024.1 - 0.029 15.1 2.8 0.073 13.8 2.8 1.7 1 0 0 1 1 1 0 RNA binding Region Cullin PF00888.22 ELR13025.1 - 1.4e-10 40.4 0.0 1.7e-10 40.2 0.0 1.1 1 0 0 1 1 1 1 Cullin family TRAP_alpha PF03896.16 ELR13026.1 - 2.8e-48 164.6 0.4 3.2e-48 164.4 0.4 1.1 1 0 0 1 1 1 1 Translocon-associated protein (TRAP), alpha subunit DUF4179 PF13786.6 ELR13026.1 - 0.071 13.6 0.3 0.26 11.8 0.0 2.1 2 1 0 2 2 2 0 Domain of unknown function (DUF4179) PhoD PF09423.10 ELR13027.1 - 1.2e-26 93.6 0.0 6.6e-26 91.1 0.0 2.0 1 1 0 1 1 1 1 PhoD-like phosphatase Pur_ac_phosph_N PF16656.5 ELR13027.1 - 2.8e-06 27.8 0.4 6.1e-06 26.7 0.4 1.6 1 0 0 1 1 1 1 Purple acid Phosphatase, N-terminal domain PhoD_N PF16655.5 ELR13027.1 - 6.2e-05 23.5 0.2 0.00014 22.4 0.2 1.6 1 0 0 1 1 1 1 PhoD-like phosphatase, N-terminal domain PolyA_pol PF01743.20 ELR13028.1 - 3.9e-30 104.9 0.0 8.5e-30 103.8 0.0 1.6 1 0 0 1 1 1 1 Poly A polymerase head domain tRNA_NucTran2_2 PF13735.6 ELR13028.1 - 8e-05 22.7 0.0 0.47 10.4 0.0 2.6 1 1 1 2 2 2 2 tRNA nucleotidyltransferase domain 2 putative CBS PF00571.28 ELR13028.1 - 0.00042 20.7 0.0 0.0014 19.1 0.0 1.9 1 0 0 1 1 1 1 CBS domain PolyA_pol_RNAbd PF12627.7 ELR13028.1 - 0.00059 19.5 0.0 0.0012 18.6 0.0 1.5 1 0 0 1 1 1 1 Probable RNA and SrmB- binding site of polymerase A NTP_transf_2 PF01909.23 ELR13028.1 - 0.0074 16.6 0.0 0.017 15.4 0.0 1.6 1 0 0 1 1 1 1 Nucleotidyltransferase domain DHHA1 PF02272.19 ELR13029.1 - 1.1e-05 25.8 0.1 2e-05 25.0 0.1 1.4 1 0 0 1 1 1 1 DHHA1 domain DHH PF01368.20 ELR13029.1 - 1.9e-05 24.9 0.0 6.1e-05 23.2 0.0 1.9 2 1 0 2 2 2 1 DHH family Pkinase_Tyr PF07714.17 ELR13030.1 - 1.3e-124 414.6 0.0 9.6e-62 208.6 0.0 2.5 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 ELR13030.1 - 3.9e-111 370.6 0.0 4.1e-56 190.3 0.0 2.4 2 0 0 2 2 2 2 Protein kinase domain PBP_like_2 PF12849.7 ELR13030.1 - 5.3e-34 118.2 28.6 3.4e-22 79.4 5.1 2.7 3 0 0 3 3 3 2 PBP superfamily domain Guanylate_cyc PF00211.20 ELR13030.1 - 1.5e-15 57.3 0.0 3.6e-15 56.1 0.0 1.6 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain APH PF01636.23 ELR13030.1 - 1.3e-06 28.6 0.1 0.00054 19.9 0.0 2.7 2 0 0 2 2 2 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 ELR13030.1 - 0.00034 19.7 0.0 0.042 12.8 0.0 2.4 2 0 0 2 2 2 1 Haspin like kinase domain TMEM154 PF15102.6 ELR13030.1 - 0.0004 20.3 0.1 0.0004 20.3 0.1 2.5 2 0 0 2 2 2 1 TMEM154 protein family Kinase-like PF14531.6 ELR13030.1 - 0.0053 16.1 0.0 0.73 9.1 0.0 2.3 2 0 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 ELR13030.1 - 0.0056 15.5 0.0 0.27 10.0 0.0 2.2 2 0 0 2 2 2 1 Fungal protein kinase FTA2 PF13095.6 ELR13030.1 - 0.055 13.1 0.1 0.76 9.4 0.0 2.6 3 0 0 3 3 3 0 Kinetochore Sim4 complex subunit FTA2 Seadorna_VP7 PF07387.11 ELR13030.1 - 0.13 11.3 0.1 0.44 9.5 0.0 1.8 2 0 0 2 2 2 0 Seadornavirus VP7 DUF3377 PF11857.8 ELR13030.1 - 0.2 11.6 0.4 0.45 10.5 0.4 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3377) EGF_2 PF07974.13 ELR13030.1 - 2.3 8.7 7.8 4.4 7.8 7.8 1.5 1 0 0 1 1 1 0 EGF-like domain SKG6 PF08693.10 ELR13030.1 - 7.8 6.0 12.7 0.4 10.1 6.0 2.3 2 0 0 2 2 2 0 Transmembrane alpha-helix domain CDC45 PF02724.14 ELR13031.1 - 0.046 12.0 1.9 0.054 11.8 1.9 1.1 1 0 0 1 1 1 0 CDC45-like protein TIMELESS_C PF05029.13 ELR13031.1 - 0.092 11.9 5.3 0.12 11.5 5.3 1.1 1 0 0 1 1 1 0 Timeless protein C terminal region PGA2 PF07543.12 ELR13031.1 - 0.43 10.6 4.5 0.74 9.8 4.5 1.4 1 0 0 1 1 1 0 Protein trafficking PGA2 RR_TM4-6 PF06459.12 ELR13031.1 - 0.51 10.1 4.4 0.69 9.7 4.4 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Spt5_N PF11942.8 ELR13031.1 - 5.6 8.0 13.2 14 6.8 13.2 1.6 1 0 0 1 1 1 0 Spt5 transcription elongation factor, acidic N-terminal TRAP_beta PF05753.14 ELR13032.1 - 0.019 14.3 0.5 0.042 13.2 0.5 1.6 1 1 0 1 1 1 0 Translocon-associated protein beta (TRAPB) IgaA PF07095.11 ELR13032.1 - 0.1 10.6 0.0 0.14 10.1 0.0 1.2 1 0 0 1 1 1 0 Intracellular growth attenuator protein IgaA LSM PF01423.22 ELR13033.1 - 3.8e-14 52.1 0.1 5.1e-14 51.7 0.1 1.2 1 0 0 1 1 1 1 LSM domain NT-C2 PF10358.9 ELR13034.1 - 7.5e-16 58.2 0.4 1.8e-15 57.0 0.4 1.6 1 0 0 1 1 1 1 N-terminal C2 in EEIG1 and EHBP1 proteins OEP PF02321.18 ELR13034.1 - 1.1e-05 25.4 0.9 1.1e-05 25.4 0.9 4.5 4 1 2 6 6 6 1 Outer membrane efflux protein Fez1 PF06818.15 ELR13034.1 - 0.0057 17.1 22.9 0.0057 17.1 22.9 5.9 3 2 3 6 6 6 3 Fez1 Cupin_8 PF13621.6 ELR13035.1 - 3.2e-58 197.4 0.0 4.5e-58 196.9 0.0 1.2 1 0 0 1 1 1 1 Cupin-like domain Cupin_4 PF08007.12 ELR13035.1 - 7e-05 22.4 0.1 0.04 13.4 0.0 2.6 3 0 0 3 3 3 2 Cupin superfamily protein MIF4G PF02854.19 ELR13036.1 - 4.9e-16 59.0 0.0 3.5e-15 56.2 0.0 2.0 1 1 0 1 1 1 1 MIF4G domain ubiquitin PF00240.23 ELR13037.1 - 0.017 14.8 0.0 0.092 12.5 0.0 2.1 2 1 0 2 2 2 0 Ubiquitin family DNA_pol_phi PF04931.13 ELR13037.1 - 0.047 11.8 11.8 0.059 11.5 11.8 1.0 1 0 0 1 1 1 0 DNA polymerase phi Nop14 PF04147.12 ELR13037.1 - 0.049 11.9 5.8 0.053 11.7 5.8 1.0 1 0 0 1 1 1 0 Nop14-like family YL1 PF05764.13 ELR13037.1 - 0.13 12.4 4.6 0.14 12.2 4.6 1.1 1 0 0 1 1 1 0 YL1 nuclear protein Sigma70_ner PF04546.13 ELR13037.1 - 0.17 11.8 4.1 0.21 11.5 4.1 1.2 1 0 0 1 1 1 0 Sigma-70, non-essential region BUD22 PF09073.10 ELR13037.1 - 0.19 11.1 3.4 0.2 10.9 3.4 1.1 1 0 0 1 1 1 0 BUD22 FAM176 PF14851.6 ELR13037.1 - 0.43 10.2 1.8 0.67 9.6 1.8 1.3 1 0 0 1 1 1 0 FAM176 family RRN3 PF05327.11 ELR13037.1 - 0.51 8.8 6.7 0.61 8.6 6.7 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 CDC45 PF02724.14 ELR13037.1 - 0.77 8.0 3.9 0.87 7.8 3.9 1.1 1 0 0 1 1 1 0 CDC45-like protein SDA1 PF05285.12 ELR13037.1 - 3.7 6.9 9.7 4.6 6.6 9.7 1.1 1 0 0 1 1 1 0 SDA1 DUF2457 PF10446.9 ELR13037.1 - 3.7 6.6 17.2 5 6.1 17.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) PBP1_TM PF14812.6 ELR13037.1 - 6.7 7.2 10.5 18 5.8 10.5 1.8 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal UBX PF00789.20 ELR13038.1 - 3.9e-17 62.2 0.0 2.9e-16 59.4 0.0 2.2 1 1 0 1 1 1 1 UBX domain DUF4554 PF15091.6 ELR13038.1 - 1.5 7.7 4.2 2.1 7.1 4.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4554) PBP1_TM PF14812.6 ELR13038.1 - 4.2 7.8 10.1 1.2 9.5 0.5 3.2 3 0 0 3 3 3 0 Transmembrane domain of transglycosylase PBP1 at N-terminal dsDNA_bind PF01984.20 ELR13039.1 - 1.1e-35 122.3 10.1 1.2e-35 122.1 10.1 1.0 1 0 0 1 1 1 1 Double-stranded DNA-binding domain MlrC_C PF07171.12 ELR13039.1 - 0.055 13.6 0.0 0.055 13.6 0.0 1.4 2 0 0 2 2 2 0 MlrC C-terminus CPSF_A PF03178.15 ELR13039.1 - 0.094 12.0 0.1 0.11 11.7 0.1 1.1 1 0 0 1 1 1 0 CPSF A subunit region AD PF09793.9 ELR13040.1 - 5.8e-24 84.1 0.0 8.1e-24 83.6 0.0 1.2 1 0 0 1 1 1 1 Anticodon-binding domain LSM PF01423.22 ELR13040.1 - 0.0016 18.1 0.0 0.0032 17.1 0.0 1.4 1 0 0 1 1 1 1 LSM domain F-box-like PF12937.7 ELR13041.1 - 2.9e-07 30.3 0.3 5e-07 29.5 0.3 1.4 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ELR13041.1 - 7e-06 25.8 0.3 1.1e-05 25.2 0.3 1.3 1 0 0 1 1 1 1 F-box domain Pkinase_Tyr PF07714.17 ELR13042.1 - 2.7e-128 426.7 0.0 1.9e-65 220.7 0.0 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 ELR13042.1 - 2.2e-106 355.1 0.0 1.8e-53 181.6 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain PBP_like_2 PF12849.7 ELR13042.1 - 9.6e-21 74.7 0.2 2.4e-12 47.1 0.2 2.4 2 0 0 2 2 2 2 PBP superfamily domain Guanylate_cyc PF00211.20 ELR13042.1 - 6.2e-10 39.0 0.0 1.2e-09 38.0 0.0 1.4 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain APH PF01636.23 ELR13042.1 - 2.8e-08 34.0 0.5 7.2e-05 22.8 0.0 3.4 3 0 0 3 3 3 2 Phosphotransferase enzyme family Haspin_kinase PF12330.8 ELR13042.1 - 1.7e-05 24.0 0.1 0.025 13.6 0.0 2.7 2 1 0 2 2 2 2 Haspin like kinase domain EGF_2 PF07974.13 ELR13042.1 - 0.00021 21.6 12.8 0.00039 20.7 12.8 1.5 1 0 0 1 1 1 1 EGF-like domain FTA2 PF13095.6 ELR13042.1 - 0.00059 19.5 0.0 0.19 11.3 0.0 2.8 2 1 1 3 3 3 2 Kinetochore Sim4 complex subunit FTA2 Kinase-like PF14531.6 ELR13042.1 - 0.00064 19.1 0.0 0.083 12.2 0.0 2.3 2 0 0 2 2 2 1 Kinase-like RIO1 PF01163.22 ELR13042.1 - 0.015 14.9 1.0 3.1 7.3 0.2 2.6 2 0 0 2 2 2 0 RIO1 family EGF_Tenascin PF18720.1 ELR13042.1 - 0.047 13.7 2.6 0.11 12.6 2.6 1.6 1 0 0 1 1 1 0 Tenascin EGF domain TMEM154 PF15102.6 ELR13042.1 - 0.052 13.5 0.0 0.11 12.3 0.0 1.5 1 0 0 1 1 1 0 TMEM154 protein family Kdo PF06293.14 ELR13042.1 - 0.07 12.5 0.3 1.4 8.3 0.1 2.4 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family EGF PF00008.27 ELR13042.1 - 2 8.8 7.4 3.7 8.0 7.4 1.5 1 0 0 1 1 1 0 EGF-like domain hEGF PF12661.7 ELR13042.1 - 3.2 8.5 6.8 7.8 7.3 6.8 1.7 1 0 0 1 1 1 0 Human growth factor-like EGF Pkinase_Tyr PF07714.17 ELR13043.1 - 2.5e-128 426.8 0.0 4.4e-63 213.0 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 ELR13043.1 - 4.6e-113 376.9 0.0 1.8e-59 201.3 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain PBP_like_2 PF12849.7 ELR13043.1 - 4.6e-32 111.8 16.2 4.7e-16 59.3 4.8 2.2 2 0 0 2 2 2 2 PBP superfamily domain Guanylate_cyc PF00211.20 ELR13043.1 - 3.6e-15 56.1 0.0 6.6e-15 55.2 0.0 1.3 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain APH PF01636.23 ELR13043.1 - 6e-09 36.2 2.1 4.9e-05 23.4 0.0 3.8 3 1 1 4 4 4 2 Phosphotransferase enzyme family Haspin_kinase PF12330.8 ELR13043.1 - 5.2e-06 25.7 0.0 0.019 14.0 0.0 3.3 3 0 0 3 3 3 2 Haspin like kinase domain EGF_2 PF07974.13 ELR13043.1 - 0.00012 22.4 9.9 0.00028 21.2 9.9 1.7 1 0 0 1 1 1 1 EGF-like domain Kinase-like PF14531.6 ELR13043.1 - 0.00018 20.9 0.0 0.27 10.5 0.0 2.3 2 0 0 2 2 2 2 Kinase-like FTA2 PF13095.6 ELR13043.1 - 0.0051 16.5 0.0 1.3 8.6 0.0 3.3 2 1 1 3 3 3 1 Kinetochore Sim4 complex subunit FTA2 Kdo PF06293.14 ELR13043.1 - 0.011 15.1 0.0 0.74 9.1 0.0 2.3 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family EB PF01683.18 ELR13043.1 - 0.014 15.7 3.7 0.03 14.6 3.7 1.5 1 0 0 1 1 1 0 EB module Pkinase_fungal PF17667.1 ELR13043.1 - 0.015 14.1 0.0 4.9 5.8 0.0 2.3 2 0 0 2 2 2 0 Fungal protein kinase EGF PF00008.27 ELR13043.1 - 0.027 14.8 5.0 0.053 13.8 5.0 1.5 1 0 0 1 1 1 0 EGF-like domain RIO1 PF01163.22 ELR13043.1 - 0.034 13.7 0.3 1.8 8.2 0.1 2.4 2 0 0 2 2 2 0 RIO1 family Seadorna_VP7 PF07387.11 ELR13043.1 - 0.061 12.4 0.2 0.15 11.0 0.0 1.7 2 0 0 2 2 2 0 Seadornavirus VP7 EGF_Tenascin PF18720.1 ELR13043.1 - 0.12 12.5 10.5 0.29 11.2 10.5 1.6 1 0 0 1 1 1 0 Tenascin EGF domain TMEM154 PF15102.6 ELR13043.1 - 0.13 12.1 0.0 0.36 10.7 0.0 1.7 1 0 0 1 1 1 0 TMEM154 protein family hEGF PF12661.7 ELR13043.1 - 0.71 10.6 5.4 2.4 8.9 5.4 2.0 1 0 0 1 1 1 0 Human growth factor-like EGF TPP_enzyme_N PF02776.18 ELR13044.1 - 1.7e-38 131.9 0.0 3e-38 131.1 0.0 1.4 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_M PF00205.22 ELR13044.1 - 9.9e-24 83.6 0.0 3.9e-23 81.7 0.0 1.9 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, central domain TPP_enzyme_C PF02775.21 ELR13044.1 - 3.3e-17 62.7 0.0 9.3e-17 61.2 0.0 1.8 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain IPP-2 PF04979.14 ELR13045.1 - 3.2e-15 57.0 33.4 3.2e-15 57.0 33.4 2.8 2 1 1 3 3 3 1 Protein phosphatase inhibitor 2 (IPP-2) Pkinase_Tyr PF07714.17 ELR13046.1 - 1.7e-127 424.1 0.0 1.1e-62 211.7 0.0 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 ELR13046.1 - 1.4e-108 362.2 0.0 8.6e-55 185.9 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain PBP_like_2 PF12849.7 ELR13046.1 - 1.8e-23 83.6 9.4 6.3e-14 52.3 1.7 2.4 2 0 0 2 2 2 2 PBP superfamily domain Guanylate_cyc PF00211.20 ELR13046.1 - 8.1e-14 51.6 0.0 1.7e-13 50.6 0.0 1.5 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain APH PF01636.23 ELR13046.1 - 6.5e-07 29.5 0.4 0.00065 19.7 0.1 3.0 2 1 0 2 2 2 2 Phosphotransferase enzyme family TMEM154 PF15102.6 ELR13046.1 - 5.3e-05 23.2 0.0 0.00014 21.8 0.0 1.6 1 0 0 1 1 1 1 TMEM154 protein family EGF_2 PF07974.13 ELR13046.1 - 9.6e-05 22.7 8.5 0.00019 21.8 8.5 1.5 1 0 0 1 1 1 1 EGF-like domain FTA2 PF13095.6 ELR13046.1 - 0.0001 22.0 0.0 0.27 10.8 0.0 3.3 2 1 1 3 3 3 1 Kinetochore Sim4 complex subunit FTA2 Haspin_kinase PF12330.8 ELR13046.1 - 0.00021 20.4 0.0 0.037 13.0 0.0 2.5 3 0 0 3 3 3 1 Haspin like kinase domain Kinase-like PF14531.6 ELR13046.1 - 0.00074 18.9 0.0 0.19 11.0 0.0 2.3 2 0 0 2 2 2 1 Kinase-like RIO1 PF01163.22 ELR13046.1 - 0.0034 17.0 0.3 0.47 10.0 0.1 2.4 2 0 0 2 2 2 1 RIO1 family Pkinase_fungal PF17667.1 ELR13046.1 - 0.014 14.2 0.0 3.1 6.5 0.0 2.2 2 0 0 2 2 2 0 Fungal protein kinase Kdo PF06293.14 ELR13046.1 - 0.025 13.9 0.1 1.7 7.9 0.0 2.4 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family EGF PF00008.27 ELR13046.1 - 0.061 13.6 3.0 0.11 12.8 3.0 1.5 1 0 0 1 1 1 0 EGF-like domain hEGF PF12661.7 ELR13046.1 - 0.07 13.8 2.3 0.15 12.7 2.3 1.6 1 0 0 1 1 1 0 Human growth factor-like EGF Seadorna_VP7 PF07387.11 ELR13046.1 - 0.2 10.6 0.2 0.64 9.0 0.0 1.8 2 0 0 2 2 2 0 Seadornavirus VP7 HMD PF03201.16 ELR13046.1 - 1.4 9.1 3.5 2.3 8.5 0.0 3.0 3 0 0 3 3 3 0 H2-forming N5,N10-methylene-tetrahydromethanopterin dehydrogenase EGF_Tenascin PF18720.1 ELR13046.1 - 1.8 8.7 5.0 4.3 7.5 5.0 1.6 1 0 0 1 1 1 0 Tenascin EGF domain K_oxygenase PF13434.6 ELR13047.1 - 0.0014 17.8 0.0 0.0016 17.7 0.0 1.1 1 0 0 1 1 1 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_9 PF13454.6 ELR13047.1 - 0.0055 16.7 0.0 0.0061 16.6 0.0 1.2 1 0 0 1 1 1 1 FAD-NAD(P)-binding NAD_binding_9 PF13454.6 ELR13048.1 - 0.093 12.7 0.1 0.21 11.6 0.0 1.7 2 1 0 2 2 2 0 FAD-NAD(P)-binding G2BR PF18442.1 ELR13050.1 - 2.9e-06 26.8 9.1 2.9e-06 26.8 9.1 1.5 2 0 0 2 2 2 1 E3 gp78 Ube2g2-binding region (G2BR) Sporozoite_P67 PF05642.11 ELR13050.1 - 0.27 9.3 5.4 0.32 9.1 5.4 1.0 1 0 0 1 1 1 0 Sporozoite P67 surface antigen SVIP PF15811.5 ELR13050.1 - 0.28 11.7 7.0 0.2 12.2 1.5 2.3 2 0 0 2 2 2 0 Small VCP/p97-interacting protein OAD_gamma PF04277.13 ELR13050.1 - 0.95 10.1 5.9 0.5 11.0 0.5 2.4 2 1 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain DIL PF01843.19 ELR13051.1 - 1.7e-18 66.8 1.3 2.4e-18 66.3 0.1 1.9 2 0 0 2 2 2 1 DIL domain NT-C2 PF10358.9 ELR13051.1 - 3.4e-13 49.5 0.7 7.6e-13 48.4 0.7 1.5 1 0 0 1 1 1 1 N-terminal C2 in EEIG1 and EHBP1 proteins NPV_P10 PF05531.12 ELR13051.1 - 0.014 15.9 0.9 0.1 13.1 0.9 2.3 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein DUF2046 PF09755.9 ELR13051.1 - 0.032 13.5 3.6 0.063 12.5 3.6 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein H4 (DUF2046) Noelin-1 PF12308.8 ELR13051.1 - 0.068 13.2 0.2 0.14 12.1 0.2 1.5 1 0 0 1 1 1 0 Neurogenesis glycoprotein USP8_interact PF08941.10 ELR13051.1 - 0.092 12.5 0.1 0.15 11.8 0.1 1.3 1 0 0 1 1 1 0 USP8 interacting SlyX PF04102.12 ELR13051.1 - 6.4 7.5 6.8 81 3.9 6.8 2.6 1 1 0 1 1 1 0 SlyX Copine PF07002.16 ELR13052.1 - 1.7e-36 125.8 0.0 1.7e-24 86.5 0.0 2.1 2 0 0 2 2 2 2 Copine YojJ PF10372.9 ELR13052.1 - 0.064 13.4 0.3 0.14 12.3 0.1 1.7 2 0 0 2 2 2 0 Bacterial membrane-spanning protein N-terminus Ras PF00071.22 ELR13053.1 - 1.1e-17 64.2 0.0 3.4e-16 59.3 0.0 2.0 1 1 0 1 1 1 1 Ras family Roc PF08477.13 ELR13053.1 - 0.0042 17.3 0.0 0.11 12.8 0.0 2.1 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR13053.1 - 0.033 13.6 0.0 0.05 13.1 0.0 1.3 1 0 0 1 1 1 0 ADP-ribosylation factor family Erf4 PF10256.9 ELR13054.1 - 0.00067 19.7 0.0 0.0035 17.5 0.0 1.9 1 1 0 1 1 1 1 Golgin subfamily A member 7/ERF4 family DUF3517 PF12030.8 ELR13054.1 - 0.056 12.3 0.1 0.15 11.0 0.0 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF3517) PIG-X PF08320.12 ELR13055.1 - 7.9e-33 114.1 0.0 3.7e-32 112.0 0.0 2.1 2 0 0 2 2 2 1 PIG-X / PBN1 Glyco_hydro_65N PF03636.15 ELR13056.1 - 5.2e-50 170.2 0.0 8.2e-50 169.5 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 65, N-terminal domain HAD_2 PF13419.6 ELR13056.1 - 7.6e-18 65.2 0.1 2.1e-12 47.5 0.0 2.5 3 0 0 3 3 3 2 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 ELR13056.1 - 4.3e-14 53.3 1.1 8.4e-14 52.3 1.1 1.5 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 ELR13056.1 - 0.00036 20.6 0.0 0.00077 19.5 0.0 1.6 1 0 0 1 1 1 1 HAD-hyrolase-like Transp_inhibit PF18791.1 ELR13056.1 - 0.0055 16.2 0.1 0.16 11.5 0.0 2.5 2 0 0 2 2 2 1 Transport inhibitor response 1 protein domain Presenilin PF01080.17 ELR13056.1 - 2.3 6.9 7.3 3.2 6.4 7.3 1.1 1 0 0 1 1 1 0 Presenilin Glyco_hydro_65m PF03632.15 ELR13057.1 - 7.6e-121 403.6 0.2 9.4e-121 403.3 0.2 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 65 central catalytic domain Glyco_hydro_65C PF03633.15 ELR13057.1 - 2.4e-05 24.1 0.4 0.00035 20.4 0.0 2.8 3 0 0 3 3 3 1 Glycosyl hydrolase family 65, C-terminal domain AMP-binding PF00501.28 ELR13058.1 - 2.7e-64 217.4 0.0 4.5e-64 216.6 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme NAD_binding_4 PF07993.12 ELR13058.1 - 7.8e-56 189.1 0.0 1.4e-55 188.2 0.0 1.4 1 0 0 1 1 1 1 Male sterility protein PP-binding PF00550.25 ELR13058.1 - 5.7e-07 29.8 0.1 1.2e-06 28.7 0.1 1.5 1 0 0 1 1 1 1 Phosphopantetheine attachment site AMP-binding_C PF13193.6 ELR13058.1 - 7.2e-05 23.7 0.2 0.00031 21.7 0.2 2.1 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain Epimerase PF01370.21 ELR13058.1 - 0.0003 20.4 0.0 0.0011 18.4 0.0 2.1 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family ZZ PF00569.17 ELR13058.1 - 0.48 10.3 8.4 0.12 12.3 4.9 1.9 2 0 0 2 2 2 0 Zinc finger, ZZ type C1_2 PF03107.16 ELR13058.1 - 2.6 8.4 6.2 6.2 7.2 6.2 1.7 1 0 0 1 1 1 0 C1 domain Kelch_4 PF13418.6 ELR13059.1 - 2.7e-18 65.7 0.7 4.1e-07 29.9 0.1 4.2 3 1 1 4 4 4 3 Galactose oxidase, central domain Kelch_5 PF13854.6 ELR13059.1 - 6.7e-18 64.3 0.1 1.1e-05 25.3 0.0 4.2 4 0 0 4 4 4 3 Kelch motif Kelch_2 PF07646.15 ELR13059.1 - 4.9e-16 58.0 7.7 6.7e-10 38.5 0.2 5.4 6 0 0 6 6 6 2 Kelch motif Kelch_6 PF13964.6 ELR13059.1 - 1.6e-15 56.7 0.3 0.00043 20.5 0.0 4.2 2 1 2 4 4 4 3 Kelch motif Kelch_3 PF13415.6 ELR13059.1 - 1.7e-13 50.5 4.1 0.00034 20.8 0.0 4.3 4 0 0 4 4 4 3 Galactose oxidase, central domain Kelch_1 PF01344.25 ELR13059.1 - 5.4e-11 41.9 1.5 0.004 16.7 0.0 4.3 4 1 0 4 4 4 3 Kelch motif CENP-B_dimeris PF09026.10 ELR13059.1 - 0.0041 17.5 0.1 0.0088 16.4 0.1 1.5 1 0 0 1 1 1 1 Centromere protein B dimerisation domain Kelch_4 PF13418.6 ELR13060.1 - 1.4e-16 60.2 0.0 9.3e-08 32.0 0.0 2.5 2 1 0 2 2 2 2 Galactose oxidase, central domain Kelch_3 PF13415.6 ELR13060.1 - 7.9e-10 38.8 0.0 4.4e-07 30.0 0.0 2.2 2 0 0 2 2 2 2 Galactose oxidase, central domain Kelch_6 PF13964.6 ELR13060.1 - 0.0016 18.7 0.0 0.45 10.9 0.0 2.2 2 0 0 2 2 2 2 Kelch motif Kelch_1 PF01344.25 ELR13060.1 - 0.011 15.3 0.1 0.055 13.1 0.0 1.9 2 0 0 2 2 2 0 Kelch motif Kelch_2 PF07646.15 ELR13060.1 - 0.016 15.2 0.0 0.14 12.2 0.0 2.1 2 1 0 2 2 2 0 Kelch motif Dus PF01207.17 ELR13061.1 - 4.3e-61 206.7 0.0 7.5e-52 176.3 0.0 3.0 2 1 0 2 2 2 2 Dihydrouridine synthase (Dus) DUF4926 PF16277.5 ELR13061.1 - 0.17 11.3 0.0 0.35 10.3 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4926) DUF2054 PF10218.9 ELR13063.1 - 4e-30 104.6 15.8 5.7e-30 104.1 15.8 1.1 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2054) BING4CT PF08149.11 ELR13064.1 - 0.017 14.9 0.0 0.037 13.8 0.0 1.5 1 0 0 1 1 1 0 BING4CT (NUC141) domain DUF885 PF05960.11 ELR13065.1 - 4.3e-159 531.5 2.8 4.9e-159 531.4 2.8 1.0 1 0 0 1 1 1 1 Bacterial protein of unknown function (DUF885) Pkinase_Tyr PF07714.17 ELR13066.1 - 6.7e-125 415.6 0.0 2.1e-61 207.5 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 ELR13066.1 - 2.3e-110 368.1 0.0 1.6e-56 191.6 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain PBP_like_2 PF12849.7 ELR13066.1 - 1.4e-27 97.1 8.2 2.3e-13 50.5 0.0 2.3 2 0 0 2 2 2 2 PBP superfamily domain Guanylate_cyc PF00211.20 ELR13066.1 - 6.6e-12 45.4 0.0 1.9e-11 43.9 0.0 1.8 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain APH PF01636.23 ELR13066.1 - 8.4e-08 32.4 0.0 0.00017 21.6 0.0 2.9 2 0 0 2 2 2 2 Phosphotransferase enzyme family FTA2 PF13095.6 ELR13066.1 - 2.7e-05 23.9 0.0 0.084 12.5 0.0 3.5 3 1 1 4 4 4 1 Kinetochore Sim4 complex subunit FTA2 Kdo PF06293.14 ELR13066.1 - 0.00011 21.6 0.2 0.2 11.0 0.0 2.4 2 0 0 2 2 2 2 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 ELR13066.1 - 0.00015 20.8 0.1 0.033 13.1 0.0 2.7 2 1 0 2 2 2 1 Haspin like kinase domain RIO1 PF01163.22 ELR13066.1 - 0.00019 21.1 0.2 0.1 12.2 0.0 2.4 2 0 0 2 2 2 2 RIO1 family Kinase-like PF14531.6 ELR13066.1 - 0.0017 17.7 0.0 0.36 10.1 0.0 2.3 2 0 0 2 2 2 1 Kinase-like TMEM154 PF15102.6 ELR13066.1 - 0.0024 17.8 0.1 0.0077 16.1 0.1 1.8 1 0 0 1 1 1 1 TMEM154 protein family Pkinase_fungal PF17667.1 ELR13066.1 - 0.0072 15.1 0.0 1.2 7.8 0.0 2.2 2 0 0 2 2 2 2 Fungal protein kinase EGF_2 PF07974.13 ELR13066.1 - 0.013 15.8 10.6 0.024 15.0 10.6 1.4 1 0 0 1 1 1 0 EGF-like domain Seadorna_VP7 PF07387.11 ELR13066.1 - 0.2 10.7 0.1 0.6 9.1 0.0 1.7 2 0 0 2 2 2 0 Seadornavirus VP7 EGF_Tenascin PF18720.1 ELR13066.1 - 0.24 11.5 5.8 0.5 10.5 5.8 1.5 1 0 0 1 1 1 0 Tenascin EGF domain EGF PF00008.27 ELR13066.1 - 1.2 9.5 5.1 2.2 8.7 5.1 1.5 1 0 0 1 1 1 0 EGF-like domain DUF4064 PF13273.6 ELR13067.1 - 0.17 12.2 8.8 0.58 10.5 2.5 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF4064) DUF4149 PF13664.6 ELR13067.1 - 0.91 9.9 8.7 0.097 13.0 3.5 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4149) Pkinase_Tyr PF07714.17 ELR13068.1 - 1.9e-119 397.7 0.0 8.6e-60 202.2 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 ELR13068.1 - 3e-109 364.5 0.0 9.5e-57 192.4 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain 5_nucleotid_C PF02872.18 ELR13068.1 - 1.3e-25 90.5 0.1 3.6e-25 89.0 0.1 1.8 1 0 0 1 1 1 1 5'-nucleotidase, C-terminal domain Guanylate_cyc PF00211.20 ELR13068.1 - 9.1e-10 38.4 0.0 2.6e-09 37.0 0.0 1.7 2 0 0 2 2 2 1 Adenylate and Guanylate cyclase catalytic domain Haspin_kinase PF12330.8 ELR13068.1 - 0.0001 21.4 0.0 0.0045 16.0 0.0 2.4 2 1 0 2 2 2 1 Haspin like kinase domain Pkinase_fungal PF17667.1 ELR13068.1 - 0.00048 19.0 0.0 0.21 10.3 0.0 2.2 2 0 0 2 2 2 2 Fungal protein kinase APH PF01636.23 ELR13068.1 - 0.00073 19.5 0.2 0.26 11.2 0.0 2.6 2 0 0 2 2 2 1 Phosphotransferase enzyme family Kinase-like PF14531.6 ELR13068.1 - 0.0036 16.7 0.0 0.14 11.4 0.0 2.4 2 0 0 2 2 2 1 Kinase-like FTA2 PF13095.6 ELR13068.1 - 0.028 14.0 0.0 2.2 7.8 0.0 2.9 3 0 0 3 3 3 0 Kinetochore Sim4 complex subunit FTA2 Toxin_ToxA PF11584.8 ELR13068.1 - 0.067 13.2 0.6 0.2 11.6 0.6 1.8 1 0 0 1 1 1 0 Proteinaceous host-selective toxin ToxA EGF_2 PF07974.13 ELR13068.1 - 0.073 13.5 9.7 0.15 12.5 9.7 1.6 1 0 0 1 1 1 0 EGF-like domain Kdo PF06293.14 ELR13068.1 - 0.13 11.6 0.1 8.5 5.7 0.0 2.3 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family IU_nuc_hydro PF01156.19 ELR13069.1 - 3.8e-44 151.5 0.5 5.1e-44 151.1 0.5 1.1 1 0 0 1 1 1 1 Inosine-uridine preferring nucleoside hydrolase Pro_racemase PF05544.11 ELR13070.1 - 1.2e-91 307.2 0.0 1.4e-91 306.9 0.0 1.0 1 0 0 1 1 1 1 Proline racemase PhzC-PhzF PF02567.16 ELR13070.1 - 0.0098 15.4 0.0 0.015 14.8 0.0 1.2 1 0 0 1 1 1 1 Phenazine biosynthesis-like protein UTP25 PF06862.12 ELR13071.1 - 4.9e-178 592.7 1.0 7.1e-178 592.2 1.0 1.2 1 0 0 1 1 1 1 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 Ribonuc_P_40 PF08584.11 ELR13071.1 - 0.13 11.5 6.5 0.29 10.4 6.5 1.5 1 0 0 1 1 1 0 Ribonuclease P 40kDa (Rpp40) subunit M_domain PF12938.7 ELR13071.1 - 2.3 8.0 18.1 4.2 7.1 18.1 1.4 1 0 0 1 1 1 0 M domain of GW182 BSP_II PF05432.11 ELR13071.1 - 3 7.5 39.2 5.8 6.5 39.2 1.4 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) Rrp15p PF07890.12 ELR13072.1 - 4.3e-09 36.8 29.9 4.3e-09 36.8 29.9 3.1 3 1 0 3 3 3 1 Rrp15p DUF4407 PF14362.6 ELR13072.1 - 4.5 6.5 16.9 2.9 7.2 6.3 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) Amino_oxidase PF01593.24 ELR13073.1 - 1.5e-25 90.5 0.0 2.2e-25 89.9 0.0 1.3 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 ELR13073.1 - 9.7e-08 32.1 0.3 3.3e-07 30.4 0.0 2.0 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 ELR13073.1 - 1.8e-06 27.8 0.2 0.0086 15.7 0.1 2.7 2 1 1 3 3 3 2 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 ELR13073.1 - 2.4e-06 26.9 0.0 1.5e-05 24.3 0.0 2.0 2 0 0 2 2 2 1 FAD binding domain FAD_oxidored PF12831.7 ELR13073.1 - 2.3e-05 23.9 0.0 5.5e-05 22.7 0.0 1.6 2 0 0 2 2 2 1 FAD dependent oxidoreductase Thi4 PF01946.17 ELR13073.1 - 0.0004 19.7 0.0 0.00071 18.9 0.0 1.3 1 0 0 1 1 1 1 Thi4 family Pyr_redox_2 PF07992.14 ELR13073.1 - 0.01 15.1 0.0 0.021 14.1 0.0 1.5 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 ELR13073.1 - 0.013 14.6 0.2 0.03 13.4 0.0 1.7 2 0 0 2 2 2 0 Lycopene cyclase protein MCRA PF06100.11 ELR13073.1 - 0.02 13.7 0.0 0.028 13.2 0.0 1.1 1 0 0 1 1 1 0 MCRA family NAD_binding_9 PF13454.6 ELR13073.1 - 0.023 14.7 0.2 0.05 13.6 0.0 1.7 2 0 0 2 2 2 0 FAD-NAD(P)-binding GDI PF00996.18 ELR13073.1 - 0.036 12.6 0.0 0.059 11.9 0.0 1.2 1 0 0 1 1 1 0 GDP dissociation inhibitor FAD_binding_3 PF01494.19 ELR13073.1 - 0.054 12.7 0.0 0.32 10.2 0.0 2.0 2 0 0 2 2 2 0 FAD binding domain HI0933_like PF03486.14 ELR13073.1 - 0.065 11.9 0.0 0.11 11.2 0.0 1.3 1 0 0 1 1 1 0 HI0933-like protein An_peroxidase PF03098.15 ELR13074.1 - 2.2e-73 247.6 0.0 3.2e-73 247.1 0.0 1.2 1 0 0 1 1 1 1 Animal haem peroxidase p450 PF00067.22 ELR13074.1 - 2.5e-57 194.7 0.0 3.9e-57 194.0 0.0 1.3 1 0 0 1 1 1 1 Cytochrome P450 Glyco_transf_28 PF03033.20 ELR13076.1 - 0.07 13.2 0.0 0.37 10.8 0.0 2.1 2 0 0 2 2 2 0 Glycosyltransferase family 28 N-terminal domain DUF2148 PF09918.9 ELR13076.1 - 0.072 13.1 0.4 0.32 11.0 0.1 2.1 2 0 0 2 2 2 0 Uncharacterized protein containing a ferredoxin domain (DUF2148) Glyco_transf_4 PF13439.6 ELR13076.1 - 0.094 12.7 2.3 0.18 11.8 0.0 2.5 3 0 0 3 3 3 0 Glycosyltransferase Family 4 UPF0176_N PF17773.1 ELR13077.1 - 2.8e-19 69.3 0.0 2.3e-17 63.1 0.0 2.3 1 1 0 1 1 1 1 UPF0176 acylphosphatase like domain Rhodanese_C PF12368.8 ELR13077.1 - 6.4e-15 55.3 7.1 1.2e-14 54.4 7.1 1.4 1 0 0 1 1 1 1 Rhodanase C-terminal Rhodanese PF00581.20 ELR13077.1 - 3.8e-07 30.6 0.0 9.3e-07 29.3 0.0 1.7 1 0 0 1 1 1 1 Rhodanese-like domain F-box-like PF12937.7 ELR13078.1 - 4.5e-09 36.1 0.2 7.8e-09 35.3 0.2 1.4 1 0 0 1 1 1 1 F-box-like Ank_2 PF12796.7 ELR13078.1 - 0.00052 20.5 0.0 0.00095 19.7 0.0 1.3 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ELR13078.1 - 0.0011 19.5 0.0 0.0027 18.2 0.0 1.6 1 1 0 1 1 1 1 Ankyrin repeats (many copies) F-box PF00646.33 ELR13078.1 - 0.0012 18.7 0.0 0.0021 17.9 0.0 1.4 1 0 0 1 1 1 1 F-box domain Ank PF00023.30 ELR13078.1 - 0.0039 17.6 0.0 0.31 11.6 0.0 2.5 2 0 0 2 2 2 1 Ankyrin repeat Ank_5 PF13857.6 ELR13078.1 - 0.027 14.8 0.0 0.062 13.7 0.0 1.6 1 0 0 1 1 1 0 Ankyrin repeats (many copies) Ank_3 PF13606.6 ELR13078.1 - 0.18 12.5 0.0 0.6 10.8 0.0 1.9 2 0 0 2 2 2 0 Ankyrin repeat Pkinase_Tyr PF07714.17 ELR13080.1 - 5.2e-48 163.6 0.0 1.1e-47 162.6 0.0 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ELR13080.1 - 2.4e-40 138.6 0.0 1.1e-27 97.1 0.0 2.4 2 0 0 2 2 2 2 Protein kinase domain COR PF16095.5 ELR13080.1 - 1.8e-20 73.6 0.0 2.6e-19 69.8 0.0 2.5 1 1 0 1 1 1 1 C-terminal of Roc, COR, domain Ank_2 PF12796.7 ELR13080.1 - 4.4e-17 62.5 0.9 3.1e-12 46.9 0.3 2.8 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Roc PF08477.13 ELR13080.1 - 1.5e-15 57.4 0.5 1.3e-10 41.5 0.0 2.9 2 1 1 3 3 3 2 Ras of Complex, Roc, domain of DAPkinase Ank_5 PF13857.6 ELR13080.1 - 3.5e-13 49.5 1.4 1.9e-05 24.8 0.1 4.4 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank_4 PF13637.6 ELR13080.1 - 7.8e-13 48.7 1.0 5e-07 30.2 0.3 3.1 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 ELR13080.1 - 9.6e-13 47.1 2.9 0.00021 21.5 0.0 4.8 5 0 0 5 5 5 2 Ankyrin repeat Ank PF00023.30 ELR13080.1 - 1.6e-10 40.9 0.3 0.00084 19.7 0.0 3.7 2 1 1 3 3 3 2 Ankyrin repeat LRR_4 PF12799.7 ELR13080.1 - 7.1e-08 32.6 1.2 3e-05 24.3 0.1 2.7 2 0 0 2 2 2 2 Leucine Rich repeats (2 copies) Ras PF00071.22 ELR13080.1 - 1.8e-07 30.9 1.2 0.00022 20.9 0.0 2.8 3 0 0 3 3 3 2 Ras family LRR_8 PF13855.6 ELR13080.1 - 3.3e-05 23.6 0.8 0.0001 22.0 0.7 1.9 1 1 1 2 2 2 1 Leucine rich repeat Orthopox_F14 PF06076.12 ELR13080.1 - 0.14 12.4 0.3 0.38 11.1 0.3 1.6 1 0 0 1 1 1 0 Orthopoxvirus F14 protein AAA_16 PF13191.6 ELR13080.1 - 0.17 12.2 0.1 0.4 11.0 0.1 1.6 1 0 0 1 1 1 0 AAA ATPase domain ERM PF00769.19 ELR13081.1 - 0.00026 20.9 13.8 0.0004 20.3 13.8 1.3 1 0 0 1 1 1 1 Ezrin/radixin/moesin family baeRF_family12 PF18856.1 ELR13081.1 - 0.02 15.5 0.8 0.053 14.1 0.8 1.7 1 0 0 1 1 1 0 Bacterial archaeo-eukaryotic release factor family 12 YabA PF06156.13 ELR13081.1 - 0.039 14.6 11.2 0.25 12.0 0.3 2.6 2 1 0 2 2 2 0 Initiation control protein YabA GAS PF13851.6 ELR13081.1 - 0.28 10.5 19.3 0.73 9.2 5.6 2.3 2 1 0 2 2 2 0 Growth-arrest specific micro-tubule binding DivIC PF04977.15 ELR13081.1 - 0.76 9.6 10.9 2.9 7.7 0.0 3.2 3 0 0 3 3 3 0 Septum formation initiator CREPT PF16566.5 ELR13081.1 - 0.78 9.9 13.2 0.066 13.4 1.3 2.2 2 0 0 2 2 2 0 Cell-cycle alteration and expression-elevated protein in tumour DUF4201 PF13870.6 ELR13081.1 - 1.3 8.8 21.8 2.7 7.7 4.8 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4201) UPF0242 PF06785.11 ELR13081.1 - 1.3 9.0 13.1 3.1 7.8 0.6 2.2 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus DUF2353 PF09789.9 ELR13081.1 - 1.7 7.9 15.3 0.083 12.2 6.4 2.2 2 0 0 2 2 2 0 Uncharacterized coiled-coil protein (DUF2353) Tox-ODYAM1 PF15642.6 ELR13081.1 - 2.8 6.8 6.8 4.7 6.1 6.8 1.3 1 0 0 1 1 1 0 Toxin in Odyssella and Amoebophilus CENP-H PF05837.12 ELR13081.1 - 6.8 7.2 14.5 0.68 10.4 4.5 2.6 2 1 0 2 2 2 0 Centromere protein H (CENP-H) DUF4140 PF13600.6 ELR13081.1 - 8.5 6.9 7.2 8.8 6.8 1.1 2.5 3 0 0 3 3 3 0 N-terminal domain of unknown function (DUF4140) Fungal_TACC PF12709.7 ELR13081.1 - 9.2 6.8 18.1 2.6 8.5 5.2 3.6 3 1 1 4 4 4 0 Fungal Transforming acidic coiled-coil (TACC) proteins Acetyltransf_1 PF00583.25 ELR13082.1 - 4e-08 33.5 0.0 5.7e-08 33.0 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 ELR13082.1 - 0.045 14.2 0.0 0.074 13.5 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 ELR13082.1 - 0.13 12.4 0.0 0.24 11.5 0.0 1.4 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase ArfGap PF01412.18 ELR13083.1 - 2e-37 127.9 0.1 1.2e-36 125.3 0.0 2.4 2 0 0 2 2 2 1 Putative GTPase activating protein for Arf BAR_3 PF16746.5 ELR13083.1 - 3.7e-19 69.4 7.1 6.4e-19 68.6 7.1 1.3 1 0 0 1 1 1 1 BAR domain of APPL family PH PF00169.29 ELR13083.1 - 2.1e-12 47.5 0.2 8.9e-12 45.5 0.0 2.2 3 0 0 3 3 2 1 PH domain Ank_2 PF12796.7 ELR13083.1 - 5.2e-11 43.0 0.2 3.8e-10 40.2 0.1 2.3 1 1 1 2 2 2 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ELR13083.1 - 8.6e-09 35.8 0.1 2.4e-08 34.4 0.1 1.8 1 0 0 1 1 1 1 Ankyrin repeats (many copies) BAR PF03114.18 ELR13083.1 - 3.8e-06 26.7 4.8 6.7e-06 25.9 4.8 1.3 1 0 0 1 1 1 1 BAR domain Ank PF00023.30 ELR13083.1 - 6.5e-06 26.4 0.2 0.003 17.9 0.1 3.3 3 0 0 3 3 3 1 Ankyrin repeat Ank_5 PF13857.6 ELR13083.1 - 1e-05 25.7 1.1 0.0013 19.0 0.2 2.6 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 ELR13083.1 - 2.3e-05 24.4 0.1 0.17 12.5 0.1 2.9 2 0 0 2 2 2 2 Ankyrin repeat BAR_2 PF10455.9 ELR13083.1 - 0.0003 20.0 2.9 0.0003 20.0 2.9 1.7 2 0 0 2 2 2 1 Bin/amphiphysin/Rvs domain for vesicular trafficking PH_11 PF15413.6 ELR13083.1 - 0.053 13.9 0.1 0.17 12.3 0.1 2.0 1 0 0 1 1 1 0 Pleckstrin homology domain PH_13 PF16652.5 ELR13083.1 - 0.063 13.1 0.0 0.2 11.5 0.0 1.8 2 0 0 2 2 2 0 Pleckstrin homology domain PH_6 PF15406.6 ELR13083.1 - 0.087 13.1 0.1 0.31 11.3 0.1 2.0 1 0 0 1 1 1 0 Pleckstrin homology domain CRAL_TRIO PF00650.20 ELR13084.1 - 8.8e-31 106.8 0.0 2.1e-30 105.5 0.0 1.7 2 0 0 2 2 2 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 ELR13084.1 - 3.3e-11 43.2 1.3 1.3e-10 41.3 1.3 2.1 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain DDHD PF02862.17 ELR13084.1 - 0.22 11.6 5.3 0.79 9.8 2.6 2.1 2 0 0 2 2 2 0 DDHD domain GAGA_bind PF06217.12 ELR13084.1 - 1.4 9.1 15.2 0.21 11.9 9.1 2.0 2 0 0 2 2 2 0 GAGA binding protein-like family Rtf2 PF04641.12 ELR13084.1 - 1.7 7.9 25.2 2 7.7 16.7 2.2 2 0 0 2 2 2 0 Rtf2 RING-finger RRN3 PF05327.11 ELR13084.1 - 2.2 6.7 8.3 0.047 12.2 1.0 1.8 2 0 0 2 2 2 0 RNA polymerase I specific transcription initiation factor RRN3 RR_TM4-6 PF06459.12 ELR13084.1 - 5.8 6.7 25.7 6.3 6.5 16.6 2.1 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 Svf1_C PF17187.4 ELR13086.1 - 4e-36 124.3 0.1 5.9e-36 123.8 0.1 1.3 1 0 0 1 1 1 1 Svf1-like C-terminal lipocalin-like domain Svf1 PF08622.10 ELR13086.1 - 1.4e-07 31.7 0.3 2.3e-07 31.0 0.3 1.3 1 0 0 1 1 1 1 Svf1-like N-terminal lipocalin domain CrtC PF07143.11 ELR13086.1 - 0.077 13.7 0.0 0.2 12.3 0.0 1.7 1 1 0 1 1 1 0 CrtC N-terminal lipocalin domain PP2C PF00481.21 ELR13087.1 - 1.9e-44 152.3 0.6 6.6e-16 58.7 0.0 3.5 3 1 0 3 3 3 3 Protein phosphatase 2C SpoIIE PF07228.12 ELR13087.1 - 2.1e-05 24.6 0.0 0.00051 20.0 0.0 2.5 2 1 0 2 2 2 1 Stage II sporulation protein E (SpoIIE) DUF3446 PF11928.8 ELR13087.1 - 0.027 14.8 3.2 0.027 14.8 3.2 2.5 3 0 0 3 3 3 0 Early growth response N-terminal domain ArfGap PF01412.18 ELR13088.1 - 5.3e-31 107.1 0.7 1.4e-30 105.8 0.0 2.0 2 0 0 2 2 2 1 Putative GTPase activating protein for Arf PH PF00169.29 ELR13088.1 - 1e-10 42.1 0.1 2.6e-10 40.7 0.1 1.8 1 0 0 1 1 1 1 PH domain Ank_2 PF12796.7 ELR13088.1 - 2e-08 34.7 0.0 9.9e-07 29.3 0.0 2.3 1 1 1 2 2 2 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ELR13088.1 - 1.4e-06 28.8 0.0 0.0014 19.1 0.0 2.7 1 1 2 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 ELR13088.1 - 0.00032 20.9 0.0 0.34 11.6 0.0 3.2 3 0 0 3 3 2 1 Ankyrin repeat Ank_5 PF13857.6 ELR13088.1 - 0.00072 19.8 0.0 0.0017 18.6 0.0 1.7 1 0 0 1 1 1 1 Ankyrin repeats (many copies) PH_11 PF15413.6 ELR13088.1 - 0.0026 18.2 1.4 0.0053 17.2 0.1 2.3 2 0 0 2 2 2 1 Pleckstrin homology domain Ank PF00023.30 ELR13088.1 - 0.0029 18.0 0.0 0.69 10.5 0.0 3.7 4 0 0 4 4 3 1 Ankyrin repeat BAR_3 PF16746.5 ELR13088.1 - 0.0051 16.5 7.2 0.0058 16.4 0.8 2.2 1 1 1 2 2 2 1 BAR domain of APPL family BAR PF03114.18 ELR13088.1 - 0.017 14.8 2.3 0.029 14.0 2.3 1.3 1 0 0 1 1 1 0 BAR domain PH_8 PF15409.6 ELR13088.1 - 0.11 12.8 0.0 0.24 11.7 0.0 1.6 1 0 0 1 1 1 0 Pleckstrin homology domain CRAL_TRIO PF00650.20 ELR13089.1 - 1.4e-33 115.9 0.1 2.1e-33 115.3 0.1 1.2 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_2 PF13716.6 ELR13089.1 - 3.8e-06 27.1 0.0 5.5e-06 26.6 0.0 1.2 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain CRAL_TRIO_N PF03765.15 ELR13089.1 - 1.8e-05 24.9 3.4 2.1e-05 24.6 1.6 2.2 2 0 0 2 2 2 1 CRAL/TRIO, N-terminal domain DUF4436 PF14494.6 ELR13090.1 - 0.024 13.9 0.5 0.04 13.2 0.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4436) Jiraiya PF15038.6 ELR13090.1 - 0.098 12.1 4.6 0.2 11.1 0.4 2.2 2 0 0 2 2 2 0 Jiraiya DUF4209 PF13910.6 ELR13092.1 - 3.2e-18 65.7 0.1 3.5e-16 59.2 0.0 2.6 2 0 0 2 2 2 2 Domain of unknown function (DUF4209) RNB PF00773.19 ELR13093.1 - 3.1e-51 174.7 3.8 1.4e-48 166.0 3.8 3.6 1 1 0 1 1 1 1 RNB domain RNase_II_C_S1 PF18614.1 ELR13093.1 - 0.00014 21.7 0.3 0.00041 20.2 0.1 1.9 2 0 0 2 2 2 1 RNase II-type exonuclease C-terminal S1 domain BioW PF03744.13 ELR13093.1 - 0.00054 19.6 0.6 0.00093 18.8 0.6 1.3 1 0 0 1 1 1 1 6-carboxyhexanoate--CoA ligase ADH_zinc_N_2 PF13602.6 ELR13095.1 - 3.5e-17 63.7 0.0 6.4e-17 62.8 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.26 ELR13095.1 - 1.7e-12 47.5 0.0 6.3e-12 45.6 0.0 1.9 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_N PF08240.12 ELR13095.1 - 1.3e-06 28.2 0.1 1.6e-05 24.8 0.0 2.1 1 1 1 2 2 2 1 Alcohol dehydrogenase GroES-like domain LIM PF00412.22 ELR13096.1 - 4.5e-28 97.2 17.7 1e-11 44.9 1.4 3.4 2 1 1 3 3 3 3 LIM domain zf-C4H2 PF10146.9 ELR13096.1 - 0.0042 17.4 0.3 0.013 15.8 0.3 1.9 1 0 0 1 1 1 1 Zinc finger-containing protein zf-dskA_traR PF01258.17 ELR13096.1 - 2.5 8.1 10.1 1.2 9.2 0.1 3.9 2 2 1 3 3 3 0 Prokaryotic dksA/traR C4-type zinc finger Pkinase_Tyr PF07714.17 ELR13097.1 - 1.9e-59 201.0 0.0 2.8e-59 200.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ELR13097.1 - 8.2e-53 179.4 0.0 1.3e-52 178.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain PBP_like_2 PF12849.7 ELR13097.1 - 5e-41 141.2 25.0 7.9e-24 84.8 1.8 2.8 3 0 0 3 3 3 2 PBP superfamily domain PBP_like PF12727.7 ELR13097.1 - 0.028 13.5 0.4 5.9 6.0 0.0 3.2 3 1 0 3 3 3 0 PBP superfamily domain FTA2 PF13095.6 ELR13097.1 - 0.041 13.5 0.0 0.086 12.5 0.0 1.5 1 1 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 Guanylate_cyc PF00211.20 ELR13097.1 - 0.05 13.2 0.0 0.093 12.3 0.0 1.4 1 0 0 1 1 1 0 Adenylate and Guanylate cyclase catalytic domain Kinase-like PF14531.6 ELR13097.1 - 0.05 12.9 0.0 0.1 11.9 0.0 1.4 1 0 0 1 1 1 0 Kinase-like TMEM154 PF15102.6 ELR13097.1 - 0.056 13.3 0.1 0.056 13.3 0.1 2.6 3 0 0 3 3 3 0 TMEM154 protein family SIR2 PF02146.17 ELR13098.1 - 4e-08 33.4 0.0 8.4e-05 22.6 0.1 2.5 2 1 0 2 2 2 2 Sir2 family Zn_Tnp_IS1595 PF12760.7 ELR13098.1 - 0.11 12.5 0.9 0.26 11.3 0.9 1.6 1 0 0 1 1 1 0 Transposase zinc-ribbon domain Ribosomal_L33 PF00471.20 ELR13099.1 - 2.7e-10 40.5 0.0 3.5e-10 40.1 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L33 tRNA-synt_1g PF09334.11 ELR13100.1 - 4.9e-152 506.2 0.0 6.3e-152 505.9 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (M) tRNA-synt_1 PF00133.22 ELR13100.1 - 2.5e-10 39.3 1.0 4.2e-05 22.0 0.0 2.3 2 0 0 2 2 2 2 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 ELR13100.1 - 1.3e-05 25.2 0.1 3.2e-05 23.9 0.1 1.7 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA GIT_CC PF16559.5 ELR13100.1 - 0.019 14.8 0.2 0.052 13.4 0.2 1.7 1 0 0 1 1 1 0 GIT coiled-coil Rho guanine nucleotide exchange factor WHEP-TRS PF00458.20 ELR13100.1 - 0.19 11.9 6.3 0.62 10.3 6.3 1.8 1 0 0 1 1 1 0 WHEP-TRS domain DZR PF12773.7 ELR13100.1 - 1 9.4 8.5 65 3.7 8.5 2.5 1 1 0 1 1 1 0 Double zinc ribbon C1_1 PF00130.22 ELR13100.1 - 1 9.3 4.3 1.4 8.9 0.3 2.5 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Cortex-I_coil PF09304.10 ELR13100.1 - 1.2 9.3 5.7 25 5.2 2.4 2.4 2 0 0 2 2 2 0 Cortexillin I, coiled coil SAM_1 PF00536.30 ELR13101.1 - 3.5e-30 104.2 0.1 2e-18 66.5 0.1 2.1 2 0 0 2 2 2 2 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 ELR13101.1 - 9.9e-25 86.4 0.1 4e-15 55.7 0.0 2.1 2 0 0 2 2 2 2 SAM domain (Sterile alpha motif) SAM_PNT PF02198.16 ELR13101.1 - 0.0001 22.2 0.0 0.0003 20.7 0.0 1.7 2 0 0 2 2 2 1 Sterile alpha motif (SAM)/Pointed domain Pox_F12L PF03337.13 ELR13101.1 - 0.0017 16.6 0.0 0.0022 16.2 0.0 1.1 1 0 0 1 1 1 1 Poxvirus F12L protein SAM_4 PF18017.1 ELR13101.1 - 0.012 15.5 0.0 0.054 13.5 0.0 1.8 2 0 0 2 2 2 0 SAM domain (Sterile alpha motif) Pkinase_Tyr PF07714.17 ELR13102.1 - 9.5e-54 182.4 0.1 1.8e-53 181.5 0.0 1.5 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.25 ELR13102.1 - 1.1e-49 169.2 0.0 2.2e-49 168.2 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain SAM_2 PF07647.17 ELR13102.1 - 2.1e-13 50.2 0.0 4.8e-13 49.0 0.0 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 ELR13102.1 - 8.6e-13 48.5 0.1 2.9e-12 46.9 0.1 2.0 2 0 0 2 2 1 1 SAM domain (Sterile alpha motif) Kdo PF06293.14 ELR13102.1 - 0.0013 18.2 0.4 0.0024 17.3 0.4 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 ELR13102.1 - 0.0065 16.4 0.1 0.35 10.7 0.0 2.4 1 1 1 2 2 2 1 Phosphotransferase enzyme family PI3K_P85_iSH2 PF16454.5 ELR13102.1 - 0.0072 15.9 3.8 0.019 14.6 3.8 1.7 1 0 0 1 1 1 1 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain RIO1 PF01163.22 ELR13102.1 - 0.031 13.9 0.2 0.031 13.9 0.2 1.8 2 0 0 2 2 1 0 RIO1 family Kinase-like PF14531.6 ELR13102.1 - 0.045 13.1 0.0 0.085 12.2 0.0 1.4 1 0 0 1 1 1 0 Kinase-like Pkinase_fungal PF17667.1 ELR13102.1 - 0.14 10.9 0.0 0.14 10.9 0.0 2.7 3 0 0 3 3 3 0 Fungal protein kinase Haspin_kinase PF12330.8 ELR13102.1 - 0.16 10.9 0.0 0.16 10.9 0.0 2.3 2 1 1 3 3 3 0 Haspin like kinase domain Choline_kinase PF01633.20 ELR13102.1 - 2 7.9 7.5 0.6 9.6 0.3 2.8 2 1 1 3 3 3 0 Choline/ethanolamine kinase RXT2_N PF08595.11 ELR13102.1 - 3.7 7.6 22.0 1.3 9.0 5.0 3.2 3 0 0 3 3 3 0 RXT2-like, N-terminal Astro_capsid_p PF12226.8 ELR13102.1 - 4.7 6.3 19.9 0.03 13.5 11.0 1.8 2 0 0 2 2 2 0 Turkey astrovirus capsid protein zf-CpG_bind_C PF12269.8 ELR13102.1 - 6.6 6.4 8.7 0.45 10.3 3.3 1.8 2 0 0 2 2 2 0 CpG binding protein zinc finger C terminal domain Seryl_tRNA_N PF02403.22 ELR13102.1 - 9.7 6.5 15.4 11 6.2 7.6 2.7 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain SAM_1 PF00536.30 ELR13103.1 - 4.5e-16 59.0 0.2 7.7e-16 58.3 0.2 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 ELR13103.1 - 7.2e-11 42.0 0.1 1.7e-10 40.8 0.1 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SR-25 PF10500.9 ELR13103.1 - 0.00073 19.2 46.2 0.00073 19.2 46.2 6.9 3 2 3 6 6 6 2 Nuclear RNA-splicing-associated protein PB1 PF00564.24 ELR13103.1 - 0.025 14.5 0.0 0.049 13.6 0.0 1.5 1 0 0 1 1 1 0 PB1 domain Lactamase_B_2 PF12706.7 ELR13104.1 - 1.2e-08 34.7 0.0 6.8e-08 32.3 0.0 2.0 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B PF00753.27 ELR13104.1 - 7.3e-05 22.9 0.0 0.00013 22.0 0.0 1.5 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Erf4 PF10256.9 ELR13105.1 - 0.011 15.9 0.0 0.52 10.4 0.0 2.6 1 1 1 2 2 2 0 Golgin subfamily A member 7/ERF4 family COR PF16095.5 ELR13106.1 - 3e-44 151.2 0.0 5.9e-44 150.2 0.0 1.5 1 0 0 1 1 1 1 C-terminal of Roc, COR, domain Pkinase_Tyr PF07714.17 ELR13106.1 - 7e-29 100.9 0.0 2.4e-22 79.4 0.0 2.5 1 1 1 2 2 2 2 Protein tyrosine kinase Roc PF08477.13 ELR13106.1 - 3e-21 75.9 0.1 1.9e-14 53.9 0.0 3.2 3 0 0 3 3 3 2 Ras of Complex, Roc, domain of DAPkinase Pkinase PF00069.25 ELR13106.1 - 3e-20 72.7 0.0 6e-16 58.6 0.0 2.6 1 1 1 2 2 2 2 Protein kinase domain LRR_8 PF13855.6 ELR13106.1 - 8.6e-16 57.5 17.5 1.1e-07 31.5 7.6 4.5 3 1 0 4 4 4 2 Leucine rich repeat LRR_6 PF13516.6 ELR13106.1 - 2.3e-14 52.2 21.7 0.0011 18.8 0.1 7.7 7 0 0 7 7 7 5 Leucine Rich repeat LRR_4 PF12799.7 ELR13106.1 - 4.6e-13 49.1 23.0 1.1e-05 25.7 4.7 5.5 3 1 3 6 6 6 4 Leucine Rich repeats (2 copies) Ras PF00071.22 ELR13106.1 - 2.4e-08 33.8 0.1 9.7e-06 25.3 0.0 2.3 2 0 0 2 2 2 2 Ras family LRR_1 PF00560.33 ELR13106.1 - 2.1e-07 30.5 12.3 3.9 8.4 0.4 7.8 7 1 0 7 7 7 2 Leucine Rich Repeat MMR_HSR1 PF01926.23 ELR13106.1 - 0.066 13.3 0.0 0.24 11.5 0.0 2.0 1 0 0 1 1 1 0 50S ribosome-binding GTPase Septin PF00735.18 ELR13106.1 - 0.15 11.3 0.0 0.15 11.3 0.0 2.2 2 0 0 2 2 1 0 Septin PhoLip_ATPase_C PF16212.5 ELR13107.1 - 6.1e-72 242.4 27.9 6.1e-72 242.4 27.9 3.0 3 1 0 3 3 3 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 ELR13107.1 - 2e-20 72.3 2.6 2e-20 72.3 2.6 2.3 2 0 0 2 2 2 1 Phospholipid-translocating ATPase N-terminal Hydrolase PF00702.26 ELR13107.1 - 1.6e-10 41.6 1.6 1.5e-05 25.4 0.5 3.3 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 ELR13107.1 - 2.1e-10 40.6 0.0 1.1e-09 38.2 0.0 2.1 2 0 0 2 2 2 1 Cation transport ATPase (P-type) E1-E2_ATPase PF00122.20 ELR13107.1 - 2.7e-05 23.8 0.0 2.7e-05 23.8 0.0 2.7 3 1 0 3 3 3 1 E1-E2 ATPase Hydrolase_3 PF08282.12 ELR13107.1 - 0.00055 19.7 0.3 0.014 15.2 0.0 2.5 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 ELR13107.1 - 0.0058 17.0 0.0 0.31 11.4 0.0 2.7 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Haspin_kinase PF12330.8 ELR13108.1 - 3.2e-09 36.2 0.1 4.8e-09 35.6 0.1 1.1 1 0 0 1 1 1 1 Haspin like kinase domain Pkinase PF00069.25 ELR13108.1 - 6.5e-07 29.0 0.1 1e-06 28.4 0.1 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR13108.1 - 0.001 18.4 0.0 0.0016 17.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase SRP-alpha_N PF04086.13 ELR13108.1 - 0.008 16.1 11.7 0.012 15.6 11.7 1.2 1 0 0 1 1 1 1 Signal recognition particle, alpha subunit, N-terminal Pox_ser-thr_kin PF05445.11 ELR13108.1 - 0.082 11.9 0.0 0.11 11.4 0.0 1.1 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase SPARC_Ca_bdg PF10591.9 ELR13108.1 - 0.17 12.2 0.8 0.33 11.3 0.0 1.8 2 0 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region ubiquitin PF00240.23 ELR13109.1 - 5.6e-35 118.9 0.8 7.5e-35 118.5 0.8 1.2 1 0 0 1 1 1 1 Ubiquitin family Ribosomal_L40e PF01020.17 ELR13109.1 - 5.7e-31 106.2 11.2 9.1e-31 105.5 11.2 1.3 1 0 0 1 1 1 1 Ribosomal L40e family Rad60-SLD PF11976.8 ELR13109.1 - 4.3e-17 61.7 0.8 5.9e-17 61.3 0.8 1.2 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 ELR13109.1 - 6.2e-06 26.6 0.2 2.3e-05 24.8 0.2 1.8 1 1 0 1 1 1 1 Ubiquitin-like domain TBK1_ULD PF18396.1 ELR13109.1 - 0.0027 17.6 0.1 0.0037 17.2 0.1 1.3 1 0 0 1 1 1 1 TANK binding kinase 1 ubiquitin-like domain Ubiquitin_5 PF18037.1 ELR13109.1 - 0.0035 17.7 0.1 0.0055 17.0 0.1 1.3 1 0 0 1 1 1 1 Ubiquitin-like domain Rad60-SLD_2 PF13881.6 ELR13109.1 - 0.0035 17.4 0.1 0.0069 16.5 0.1 1.6 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.9 ELR13109.1 - 0.0047 17.5 0.1 0.0052 17.3 0.1 1.2 1 0 0 1 1 1 1 DUF2407 ubiquitin-like domain Ubiquitin_4 PF18036.1 ELR13109.1 - 0.011 15.8 1.2 1.9 8.6 0.2 2.2 2 0 0 2 2 2 0 Ubiquitin-like domain COMM_domain PF07258.14 ELR13110.1 - 1.6e-12 47.4 0.6 5.2e-12 45.7 0.1 2.1 2 1 0 2 2 2 1 COMM domain NFACT-C PF11923.8 ELR13110.1 - 0.074 13.0 0.0 0.16 11.9 0.0 1.6 1 0 0 1 1 1 0 NFACT protein C-terminal domain eIF-5a PF01287.20 ELR13111.1 - 1.5e-06 28.2 0.0 2.2e-06 27.6 0.0 1.3 1 0 0 1 1 1 1 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold UpxZ PF06603.11 ELR13111.1 - 0.046 14.0 0.0 0.059 13.7 0.0 1.1 1 0 0 1 1 1 0 UpxZ family of transcription anti-terminator antagonists PELOTA_1 PF15608.6 ELR13111.1 - 0.12 12.3 0.0 0.21 11.5 0.0 1.4 1 0 0 1 1 1 0 PELOTA RNA binding domain AIG2_2 PF13772.6 ELR13112.1 - 0.00014 22.2 0.0 0.00029 21.2 0.0 1.6 1 0 0 1 1 1 1 AIG2-like family GGACT PF06094.12 ELR13112.1 - 0.00042 20.9 0.0 0.00066 20.3 0.0 1.3 1 0 0 1 1 1 1 Gamma-glutamyl cyclotransferase, AIG2-like Serpin PF00079.20 ELR13113.1 - 4.2e-58 197.4 0.0 5.3e-58 197.1 0.0 1.1 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Sacchrp_dh_C PF16653.5 ELR13114.1 - 1.4e-81 274.5 0.2 1.3e-80 271.3 0.2 2.0 1 1 0 1 1 1 1 Saccharopine dehydrogenase C-terminal domain Sacchrp_dh_NADP PF03435.18 ELR13114.1 - 1.7e-14 54.2 0.0 3e-14 53.4 0.0 1.4 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain OCD_Mu_crystall PF02423.15 ELR13114.1 - 1.8e-05 23.8 0.0 2.9e-05 23.2 0.0 1.2 1 0 0 1 1 1 1 Ornithine cyclodeaminase/mu-crystallin family TrkA_N PF02254.18 ELR13114.1 - 0.039 14.2 0.0 0.16 12.2 0.0 2.1 2 0 0 2 2 2 0 TrkA-N domain adh_short PF00106.25 ELR13116.1 - 1.4e-49 168.3 0.0 1.8e-49 167.9 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ELR13116.1 - 6.5e-31 107.7 0.0 8.5e-31 107.3 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ELR13116.1 - 3.3e-09 36.9 0.0 6.3e-09 36.0 0.0 1.4 1 1 0 1 1 1 1 KR domain CoA_binding_3 PF13727.6 ELR13116.1 - 0.00064 19.8 1.3 0.0011 19.0 1.3 1.4 1 0 0 1 1 1 1 CoA-binding domain Epimerase PF01370.21 ELR13116.1 - 0.00074 19.0 0.1 0.0014 18.2 0.1 1.4 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family AlaDh_PNT_C PF01262.21 ELR13116.1 - 0.011 15.0 0.1 0.018 14.3 0.1 1.2 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain TrkA_N PF02254.18 ELR13116.1 - 0.044 14.0 0.1 0.078 13.2 0.1 1.4 1 0 0 1 1 1 0 TrkA-N domain LapA_dom PF06305.11 ELR13116.1 - 0.087 12.7 5.0 0.28 11.0 5.0 1.8 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain Polysacc_synt_2 PF02719.15 ELR13116.1 - 0.11 11.6 0.0 0.15 11.2 0.0 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein MTS PF05175.14 ELR13116.1 - 0.2 11.2 0.0 1.2 8.7 0.0 2.1 3 0 0 3 3 3 0 Methyltransferase small domain T2SSG PF08334.11 ELR13117.1 - 0.038 14.0 0.2 0.084 13.0 0.1 1.5 1 1 1 2 2 2 0 Type II secretion system (T2SS), protein G Ac76 PF05814.11 ELR13117.1 - 0.21 11.6 0.4 0.47 10.5 0.4 1.5 1 0 0 1 1 1 0 Orf76 (Ac76) DUF966 PF06136.13 ELR13118.1 - 1.7 8.3 27.6 2.7 7.6 27.6 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF966) GREB1 PF15782.5 ELR13118.1 - 1.8 5.6 22.3 2.4 5.2 22.3 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Macoilin PF09726.9 ELR13118.1 - 9.2 4.7 27.9 11 4.4 27.9 1.1 1 0 0 1 1 1 0 Macoilin family ABC_membrane PF00664.23 ELR13119.1 - 3.5e-61 207.3 3.5 5.4e-61 206.7 3.5 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 ELR13119.1 - 9.4e-36 123.3 0.0 2.2e-35 122.1 0.0 1.7 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 ELR13119.1 - 1.3e-06 28.1 0.7 0.00023 20.7 0.0 2.3 1 1 0 2 2 2 2 RecF/RecN/SMC N terminal domain Zeta_toxin PF06414.12 ELR13119.1 - 9.2e-05 21.8 0.0 0.00083 18.7 0.0 2.2 2 0 0 2 2 2 1 Zeta toxin AAA_29 PF13555.6 ELR13119.1 - 0.0014 18.4 0.0 0.0034 17.1 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_30 PF13604.6 ELR13119.1 - 0.0042 16.8 0.2 0.085 12.6 0.0 2.5 3 0 0 3 3 3 1 AAA domain AAA_16 PF13191.6 ELR13119.1 - 0.0097 16.3 0.4 0.032 14.6 0.2 2.1 2 1 0 2 2 2 1 AAA ATPase domain ABC_ATPase PF09818.9 ELR13119.1 - 0.011 14.6 0.0 0.026 13.4 0.0 1.6 1 0 0 1 1 1 0 Predicted ATPase of the ABC class DEAD PF00270.29 ELR13119.1 - 0.017 14.9 0.0 0.046 13.5 0.0 1.6 1 1 0 1 1 1 0 DEAD/DEAH box helicase AAA_22 PF13401.6 ELR13119.1 - 0.026 14.8 0.1 0.16 12.2 0.1 2.1 1 1 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 ELR13119.1 - 0.058 13.3 0.0 0.15 12.0 0.0 1.6 1 0 0 1 1 1 0 RsgA GTPase G-alpha PF00503.20 ELR13119.1 - 0.16 11.1 0.0 0.26 10.4 0.0 1.2 1 0 0 1 1 1 0 G-protein alpha subunit SbcCD_C PF13558.6 ELR13119.1 - 3.4 7.9 5.3 1.6 9.0 0.4 2.8 2 1 0 2 2 2 0 Putative exonuclease SbcCD, C subunit BACK PF07707.15 ELR13120.1 - 2.4e-16 59.7 0.7 1.8e-15 56.9 0.1 2.5 2 1 1 3 3 3 1 BTB And C-terminal Kelch BTB PF00651.31 ELR13120.1 - 3.5e-08 33.7 0.1 1.2e-07 31.9 0.0 1.9 2 0 0 2 2 2 1 BTB/POZ domain CDC27 PF09507.10 ELR13120.1 - 0.0061 16.0 9.3 0.0087 15.5 9.3 1.2 1 0 0 1 1 1 1 DNA polymerase subunit Cdc27 Myc_N PF01056.18 ELR13120.1 - 0.023 14.6 3.0 0.037 13.9 3.0 1.3 1 0 0 1 1 1 0 Myc amino-terminal region CDC45 PF02724.14 ELR13120.1 - 0.074 11.3 4.8 0.1 10.9 4.8 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF3408 PF11888.8 ELR13120.1 - 0.11 12.7 3.9 0.2 11.8 3.9 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3408) NLRC4_HD2 PF17776.1 ELR13120.1 - 0.21 12.1 2.5 2 9.0 1.2 2.5 1 1 1 2 2 2 0 NLRC4 helical domain HD2 RR_TM4-6 PF06459.12 ELR13120.1 - 0.25 11.1 5.6 0.37 10.6 5.6 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Pox_Ag35 PF03286.14 ELR13120.1 - 0.36 10.6 6.8 0.62 9.8 6.8 1.3 1 0 0 1 1 1 0 Pox virus Ag35 surface protein Presenilin PF01080.17 ELR13120.1 - 4.5 5.9 7.0 6.5 5.4 7.0 1.1 1 0 0 1 1 1 0 Presenilin Pkinase_Tyr PF07714.17 ELR13121.1 - 9.3e-129 428.2 0.0 9.3e-65 218.5 0.1 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 ELR13121.1 - 1.6e-111 371.9 0.0 9.1e-56 189.1 0.0 2.3 2 0 0 2 2 2 2 Protein kinase domain PBP_like_2 PF12849.7 ELR13121.1 - 1.4e-25 90.5 10.8 3.7e-14 53.1 3.8 2.3 2 0 0 2 2 2 2 PBP superfamily domain Guanylate_cyc PF00211.20 ELR13121.1 - 2.2e-09 37.2 0.0 8.2e-06 25.6 0.0 2.3 2 0 0 2 2 2 2 Adenylate and Guanylate cyclase catalytic domain APH PF01636.23 ELR13121.1 - 1.5e-06 28.3 0.0 0.0014 18.6 0.0 2.9 2 0 0 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.14 ELR13121.1 - 0.00011 21.7 0.2 0.51 9.7 0.1 2.3 2 0 0 2 2 2 2 Lipopolysaccharide kinase (Kdo/WaaP) family EGF_2 PF07974.13 ELR13121.1 - 0.00014 22.1 11.9 0.00027 21.3 11.9 1.5 1 0 0 1 1 1 1 EGF-like domain Kinase-like PF14531.6 ELR13121.1 - 0.00026 20.4 0.0 0.062 12.6 0.0 2.2 2 0 0 2 2 2 2 Kinase-like Haspin_kinase PF12330.8 ELR13121.1 - 0.00041 19.4 0.0 0.089 11.7 0.0 2.7 3 0 0 3 3 3 1 Haspin like kinase domain FTA2 PF13095.6 ELR13121.1 - 0.0026 17.4 0.0 0.074 12.7 0.0 2.6 2 1 1 3 3 3 1 Kinetochore Sim4 complex subunit FTA2 DUF4064 PF13273.6 ELR13121.1 - 0.03 14.6 0.3 0.084 13.2 0.3 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF4064) RIO1 PF01163.22 ELR13121.1 - 0.064 12.8 2.6 6.1 6.4 1.1 2.7 2 1 0 2 2 2 0 RIO1 family I-EGF_1 PF18372.1 ELR13121.1 - 0.26 11.4 6.3 0.53 10.4 6.3 1.5 1 0 0 1 1 1 0 Integrin beta epidermal growth factor like domain 1 EGF PF00008.27 ELR13121.1 - 1.3 9.4 6.0 2.3 8.6 6.0 1.4 1 0 0 1 1 1 0 EGF-like domain EGF_Tenascin PF18720.1 ELR13121.1 - 1.6 8.9 8.0 4.1 7.5 8.0 1.6 1 0 0 1 1 1 0 Tenascin EGF domain hEGF PF12661.7 ELR13121.1 - 7.8 7.3 7.3 26 5.6 7.3 1.9 1 0 0 1 1 1 0 Human growth factor-like EGF HEAT_2 PF13646.6 ELR13122.1 - 0.00063 20.1 3.6 0.034 14.5 0.0 4.1 4 1 0 4 4 4 1 HEAT repeats DnaG_DnaB_bind PF08278.11 ELR13122.1 - 0.58 10.8 4.8 0.99 10.0 0.3 3.5 4 0 0 4 4 4 0 DNA primase DnaG DnaB-binding SPDY PF03771.16 ELR13123.1 - 0.009 15.9 2.8 0.18 11.8 1.1 2.7 2 0 0 2 2 2 2 Domain of unknown function (DUF317) Exo_endo_phos PF03372.23 ELR13125.1 - 6.9e-12 45.4 0.0 1.6e-06 27.8 0.0 2.2 2 0 0 2 2 2 2 Endonuclease/Exonuclease/phosphatase family U1snRNP70_N PF12220.8 ELR13125.1 - 0.48 11.1 6.9 0.13 12.9 1.6 2.3 2 0 0 2 2 2 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal LRR_8 PF13855.6 ELR13126.1 - 3.6e-13 49.0 6.8 2.1e-12 46.6 4.9 2.2 2 0 0 2 2 2 1 Leucine rich repeat LRR_4 PF12799.7 ELR13126.1 - 1.6e-12 47.4 18.6 2.7e-06 27.6 1.0 2.6 1 1 2 3 3 3 3 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 ELR13126.1 - 0.00067 19.9 10.2 1.2 10.0 1.1 3.9 4 1 0 4 4 4 2 Leucine Rich Repeat LRR_6 PF13516.6 ELR13126.1 - 0.006 16.5 11.9 0.026 14.5 0.2 3.5 4 0 0 4 4 4 2 Leucine Rich repeat Pkinase_Tyr PF07714.17 ELR13127.1 - 7e-128 425.3 0.0 7.8e-65 218.7 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 ELR13127.1 - 2.3e-111 371.4 0.0 6.8e-55 186.3 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain PBP_like_2 PF12849.7 ELR13127.1 - 2.8e-30 106.0 13.2 7.9e-16 58.6 5.9 2.3 2 0 0 2 2 2 2 PBP superfamily domain Guanylate_cyc PF00211.20 ELR13127.1 - 1.1e-10 41.4 0.0 2.1e-10 40.5 0.0 1.4 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain APH PF01636.23 ELR13127.1 - 2.5e-06 27.6 0.0 0.0022 17.9 0.0 3.0 2 0 0 2 2 2 2 Phosphotransferase enzyme family Kinase-like PF14531.6 ELR13127.1 - 0.00025 20.4 0.0 0.03 13.6 0.0 2.2 2 0 0 2 2 2 1 Kinase-like Haspin_kinase PF12330.8 ELR13127.1 - 0.00041 19.4 0.1 0.091 11.7 0.0 2.7 3 0 0 3 3 3 1 Haspin like kinase domain EGF_2 PF07974.13 ELR13127.1 - 0.001 19.4 10.1 0.002 18.5 10.1 1.5 1 0 0 1 1 1 1 EGF-like domain FTA2 PF13095.6 ELR13127.1 - 0.0025 17.5 0.0 0.064 12.9 0.0 2.6 2 1 1 3 3 3 1 Kinetochore Sim4 complex subunit FTA2 Kdo PF06293.14 ELR13127.1 - 0.0031 16.9 0.1 1.4 8.3 0.0 2.4 2 0 0 2 2 2 2 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 ELR13127.1 - 0.05 13.2 1.7 5.5 6.6 0.5 2.7 2 1 0 2 2 2 0 RIO1 family EGF PF00008.27 ELR13127.1 - 1.1 9.6 4.3 2 8.8 4.3 1.5 1 0 0 1 1 1 0 EGF-like domain EGF_Tenascin PF18720.1 ELR13127.1 - 3.6 7.7 9.0 8 6.6 9.0 1.6 1 0 0 1 1 1 0 Tenascin EGF domain SKG6 PF08693.10 ELR13127.1 - 7 6.1 11.1 0.17 11.3 2.2 2.6 2 0 0 2 2 2 0 Transmembrane alpha-helix domain WD40 PF00400.32 ELR13128.1 - 1.2e-06 29.1 4.1 0.13 13.2 0.0 4.8 6 0 0 6 6 6 2 WD domain, G-beta repeat AF-4 PF05110.13 ELR13128.1 - 0.0091 14.1 7.3 0.012 13.8 7.3 1.0 1 0 0 1 1 1 1 AF-4 proto-oncoprotein CCDC53 PF10152.9 ELR13128.1 - 1.2 9.6 2.8 2 8.9 2.8 1.4 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex SR-25 PF10500.9 ELR13128.1 - 2 8.0 11.5 4.2 6.9 11.5 1.5 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Glyco_hydro_63 PF03200.16 ELR13129.1 - 7.4e-96 321.8 14.0 3.3e-43 148.2 5.9 5.7 1 1 2 3 3 3 3 Glycosyl hydrolase family 63 C-terminal domain Glyco_hydro_63N PF16923.5 ELR13129.1 - 2.9e-48 165.0 0.1 1.5e-47 162.6 0.1 2.1 1 1 0 1 1 1 1 Glycosyl hydrolase family 63 N-terminal domain Pro-kuma_activ PF09286.11 ELR13130.1 - 4.2e-26 91.9 0.1 9e-26 90.9 0.1 1.6 1 0 0 1 1 1 1 Pro-kumamolisin, activation domain DUF2671 PF10877.8 ELR13130.1 - 0.029 14.2 0.0 0.059 13.2 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2671) Copine PF07002.16 ELR13131.1 - 9.9e-49 165.7 0.0 1.4e-48 165.2 0.0 1.1 1 0 0 1 1 1 1 Copine C2 PF00168.30 ELR13131.1 - 7.9e-19 67.9 0.0 1.8e-10 41.0 0.0 2.8 3 0 0 3 3 3 2 C2 domain vWA-TerF-like PF10138.9 ELR13131.1 - 0.0081 16.3 0.0 0.017 15.2 0.0 1.5 1 0 0 1 1 1 1 vWA found in TerF C terminus Uso1_p115_head PF04869.14 ELR13132.1 - 6.2e-22 78.1 0.0 9e-21 74.3 0.0 2.3 2 1 1 3 3 3 2 Uso1 / p115 like vesicle tethering protein, head region RTP1_C1 PF10363.9 ELR13132.1 - 2.1e-06 27.9 0.7 0.058 13.6 0.0 3.9 3 1 1 4 4 4 2 Required for nuclear transport of RNA pol II C-terminus 1 HEAT_2 PF13646.6 ELR13132.1 - 0.00019 21.8 4.5 4 7.9 0.1 4.0 4 0 0 4 4 4 2 HEAT repeats Atx10homo_assoc PF09759.9 ELR13132.1 - 0.00031 20.7 0.0 0.24 11.5 0.0 3.0 3 1 0 3 3 3 2 Spinocerebellar ataxia type 10 protein domain HEAT PF02985.22 ELR13132.1 - 0.00037 20.5 0.4 3.9 8.0 0.0 3.9 3 0 0 3 3 3 2 HEAT repeat Cnd1 PF12717.7 ELR13132.1 - 0.00054 20.0 0.6 0.0023 18.0 0.1 2.2 2 1 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1 Adaptin_N PF01602.20 ELR13132.1 - 0.00075 18.2 1.6 0.0031 16.2 0.1 2.4 2 1 1 3 3 3 1 Adaptin N terminal region V-ATPase_H_N PF03224.14 ELR13132.1 - 0.0053 16.1 0.2 0.022 14.1 0.0 2.1 2 1 0 2 2 2 1 V-ATPase subunit H Arm_vescicular PF18770.1 ELR13132.1 - 0.0059 16.5 0.0 0.02 14.8 0.0 1.9 1 0 0 1 1 1 1 Armadillo tether-repeat of vescicular transport factor HEAT_EZ PF13513.6 ELR13132.1 - 0.1 13.2 1.2 65 4.2 0.1 4.2 3 1 1 4 4 4 0 HEAT-like repeat DUF3361 PF11841.8 ELR13132.1 - 0.34 10.8 3.2 11 5.9 0.2 2.7 2 1 1 3 3 3 0 Domain of unknown function (DUF3361) Ntox33 PF15533.6 ELR13138.1 - 0.013 16.0 0.0 0.086 13.3 0.0 2.3 2 0 0 2 2 2 0 Bacterial toxin 33 DUF5080 PF16883.5 ELR13141.1 - 0.0046 17.1 2.2 0.0092 16.1 2.2 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF5080) TrbC PF04956.13 ELR13141.1 - 0.03 14.5 8.7 1.1 9.5 2.2 2.3 2 0 0 2 2 2 0 TrbC/VIRB2 family DUF3120 PF11318.8 ELR13141.1 - 0.031 14.6 0.6 0.031 14.6 0.6 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3120) DUF5453 PF17534.2 ELR13141.1 - 0.034 14.1 3.7 0.26 11.2 0.2 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5453) DUF4181 PF13789.6 ELR13141.1 - 0.058 13.7 1.6 0.12 12.6 1.6 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4181) DUF4335 PF14233.6 ELR13141.1 - 0.15 11.9 0.1 0.57 10.1 0.0 1.6 1 1 0 2 2 2 0 Domain of unknown function (DUF4335) MARVEL PF01284.23 ELR13141.1 - 0.27 11.3 0.1 0.27 11.3 0.1 2.5 2 1 0 2 2 2 0 Membrane-associating domain DUF2207 PF09972.9 ELR13141.1 - 0.27 10.0 2.8 0.35 9.6 1.6 1.5 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) Pilin_N PF07790.11 ELR13141.1 - 0.58 11.1 10.5 8.2 7.4 0.5 2.8 2 0 0 2 2 2 0 Archaeal Type IV pilin, N-terminal Adeno_E3_CR1 PF02440.15 ELR13141.1 - 7.3 6.4 11.5 3.9 7.3 1.7 2.8 3 0 0 3 3 3 0 Adenovirus E3 region protein CR1 Ank_5 PF13857.6 ELR13142.1 - 1.6e-12 47.4 0.0 2.1e-12 47.0 0.0 1.2 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_4 PF13637.6 ELR13142.1 - 4.8e-09 36.6 0.1 7e-08 32.9 0.0 2.3 1 1 1 2 2 2 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 ELR13142.1 - 8.4e-08 32.7 0.1 2.6e-07 31.1 0.1 1.7 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.30 ELR13142.1 - 1.9e-07 31.2 2.7 7.4e-06 26.2 0.1 2.7 2 1 1 3 3 3 1 Ankyrin repeat Ank_3 PF13606.6 ELR13142.1 - 3.8e-06 26.8 0.3 0.00024 21.3 0.0 2.7 3 0 0 3 3 3 1 Ankyrin repeat F-box-like PF12937.7 ELR13143.1 - 0.0017 18.2 0.1 0.004 17.0 0.1 1.6 1 0 0 1 1 1 1 F-box-like zf-MIZ PF02891.20 ELR13144.1 - 0.00024 20.8 0.1 0.00054 19.7 0.1 1.6 1 0 0 1 1 1 1 MIZ/SP-RING zinc finger PsaM PF07465.13 ELR13146.1 - 0.16 11.7 0.4 0.24 11.2 0.4 1.2 1 0 0 1 1 1 0 Photosystem I protein M (PsaM) Sulfate_transp PF00916.20 ELR13147.1 - 1.4e-39 135.9 18.6 5e-39 134.1 10.8 2.1 1 1 1 2 2 2 2 Sulfate permease family STAS PF01740.21 ELR13147.1 - 0.0003 20.4 0.0 0.00064 19.3 0.0 1.5 1 0 0 1 1 1 1 STAS domain STAS_2 PF13466.6 ELR13147.1 - 0.00039 20.7 0.3 0.0035 17.7 0.0 2.5 2 0 0 2 2 2 1 STAS domain BTB PF00651.31 ELR13149.1 - 9.2e-08 32.3 0.1 3.3e-06 27.3 0.1 2.0 1 1 1 2 2 2 2 BTB/POZ domain RCC1 PF00415.18 ELR13150.1 - 2e-40 137.2 22.0 4.2e-09 36.9 0.5 10.5 9 2 0 9 9 9 8 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 ELR13150.1 - 5.2e-36 121.7 33.6 1.4e-08 34.3 1.2 8.5 8 0 0 8 8 8 8 Regulator of chromosome condensation (RCC1) repeat BTB PF00651.31 ELR13150.1 - 0.002 18.3 0.0 0.0033 17.6 0.0 1.3 1 0 0 1 1 1 1 BTB/POZ domain Hira PF07569.11 ELR13150.1 - 0.0074 16.0 2.9 2.7 7.7 0.1 3.4 2 1 2 4 4 4 2 TUP1-like enhancer of split DUF1921 PF09081.10 ELR13150.1 - 0.075 13.3 0.0 17 5.8 0.0 3.7 5 0 0 5 5 5 0 Domain of unknown function (DUF1921) Glyco_trans_2_3 PF13632.6 ELR13152.1 - 2.5e-07 30.8 3.1 4.9e-07 29.8 3.1 1.8 1 1 0 1 1 1 1 Glycosyl transferase family group 2 Cellulose_synt PF03552.14 ELR13152.1 - 4.9e-07 28.6 3.8 1.2e-06 27.4 3.8 1.6 1 1 0 1 1 1 1 Cellulose synthase DUF4131 PF13567.6 ELR13152.1 - 1.9 8.1 5.9 5.3 6.7 0.5 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) HEAT_2 PF13646.6 ELR13153.1 - 4.7e-05 23.7 0.6 0.00062 20.1 0.3 3.0 2 1 0 2 2 2 1 HEAT repeats HEAT_EZ PF13513.6 ELR13153.1 - 0.0031 18.0 4.8 1.9 9.1 0.0 4.9 4 1 0 4 4 4 2 HEAT-like repeat Adaptin_N PF01602.20 ELR13153.1 - 0.11 11.1 0.0 0.17 10.4 0.0 1.2 1 0 0 1 1 1 0 Adaptin N terminal region HEAT PF02985.22 ELR13153.1 - 0.86 10.0 13.9 3.9 8.0 0.0 6.1 8 0 0 8 8 8 0 HEAT repeat Glyco_trans_2_3 PF13632.6 ELR13154.1 - 5.6e-15 55.8 0.2 5.6e-15 55.8 0.2 3.5 3 0 0 3 3 3 1 Glycosyl transferase family group 2 Cellulose_synt PF03552.14 ELR13154.1 - 6.4e-12 44.8 11.9 1.6e-06 26.9 2.8 2.9 2 1 1 3 3 3 2 Cellulose synthase Glyco_tranf_2_3 PF13641.6 ELR13154.1 - 2.7e-07 30.7 0.0 6.1e-07 29.6 0.0 1.6 1 1 0 1 1 1 1 Glycosyltransferase like family 2 DUF4203 PF13886.6 ELR13154.1 - 1.6e-06 27.9 13.3 1.6e-06 27.9 13.3 2.9 4 0 0 4 4 4 1 Domain of unknown function (DUF4203) Glycos_transf_2 PF00535.26 ELR13154.1 - 5.2e-05 23.1 0.1 0.00013 21.8 0.1 1.7 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_transf_21 PF13506.6 ELR13154.1 - 0.001 18.6 0.0 0.0062 16.0 0.0 2.1 1 1 0 1 1 1 1 Glycosyl transferase family 21 DUF4834 PF16118.5 ELR13154.1 - 1.2 10.1 0.0 1.2 10.1 0.0 3.4 4 0 0 4 4 4 0 Domain of unknown function (DUF4834) DEAD PF00270.29 ELR13155.1 - 3.2e-37 128.0 0.1 7.9e-37 126.7 0.0 1.7 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ELR13155.1 - 1e-26 93.5 1.3 3.1e-25 88.7 0.2 3.1 4 0 0 4 4 4 1 Helicase conserved C-terminal domain ResIII PF04851.15 ELR13155.1 - 7e-07 29.4 0.0 1.3e-06 28.5 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit CMS1 PF14617.6 ELR13155.1 - 0.029 13.7 0.0 0.061 12.7 0.0 1.5 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit UvrD-helicase PF00580.21 ELR13155.1 - 0.037 13.5 0.4 3.5 7.1 0.0 2.3 2 0 0 2 2 2 0 UvrD/REP helicase N-terminal domain AAA_30 PF13604.6 ELR13155.1 - 0.059 13.1 0.0 0.11 12.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_19 PF13245.6 ELR13155.1 - 0.15 12.4 0.1 0.41 11.0 0.1 2.0 1 1 0 1 1 1 0 AAA domain zf-HIT PF04438.16 ELR13157.1 - 1.2e-07 31.4 6.5 1.2e-07 31.4 6.5 1.9 2 1 0 2 2 2 1 HIT zinc finger TIMELESS PF04821.14 ELR13159.1 - 1.8e-47 161.9 0.6 1.8e-47 161.9 0.6 1.3 2 0 0 2 2 2 1 Timeless protein CheX PF13690.6 ELR13159.1 - 0.072 13.3 0.0 0.27 11.4 0.0 1.9 1 1 1 2 2 2 0 Chemotaxis phosphatase CheX CENP-B_dimeris PF09026.10 ELR13161.1 - 9.2 6.7 26.7 11 6.5 0.0 4.5 4 0 0 4 4 4 0 Centromere protein B dimerisation domain HECT PF00632.25 ELR13162.1 - 2.4e-58 198.0 0.0 3.6e-58 197.4 0.0 1.2 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) EF_assoc_1 PF08355.12 ELR13162.1 - 0.0057 16.2 0.1 0.016 14.8 0.1 1.7 1 0 0 1 1 1 1 EF hand associated BBP1_C PF15272.6 ELR13162.1 - 0.28 11.0 2.5 9.5 6.0 0.2 2.3 2 0 0 2 2 2 0 Spindle pole body component BBP1, C-terminal Actino_peptide PF14408.6 ELR13162.1 - 0.31 11.2 7.8 0.71 10.0 7.8 1.5 1 0 0 1 1 1 0 Ribosomally synthesised peptide in actinomycetes DUF3446 PF11928.8 ELR13162.1 - 0.33 11.3 4.8 0.28 11.5 1.7 2.2 2 0 0 2 2 2 0 Early growth response N-terminal domain Nop14 PF04147.12 ELR13164.1 - 0.043 12.1 17.0 0.067 11.4 17.0 1.3 1 0 0 1 1 1 0 Nop14-like family PPP4R2 PF09184.11 ELR13164.1 - 0.044 13.4 11.9 0.086 12.4 11.9 1.4 1 0 0 1 1 1 0 PPP4R2 CDC45 PF02724.14 ELR13164.1 - 0.061 11.6 13.0 0.1 10.9 13.0 1.3 1 0 0 1 1 1 0 CDC45-like protein BUD22 PF09073.10 ELR13164.1 - 0.12 11.7 24.6 0.0076 15.6 19.6 1.5 2 0 0 2 2 2 0 BUD22 SDA1 PF05285.12 ELR13164.1 - 0.6 9.5 23.7 0.014 14.9 16.7 1.8 2 0 0 2 2 2 0 SDA1 NOA36 PF06524.12 ELR13164.1 - 1.1 8.6 12.7 2.1 7.6 12.7 1.4 1 0 0 1 1 1 0 NOA36 protein TAF4 PF05236.14 ELR13164.1 - 1.5 8.5 16.4 0.13 12.0 9.4 2.2 2 0 0 2 2 2 0 Transcription initiation factor TFIID component TAF4 family RRN3 PF05327.11 ELR13164.1 - 1.8 7.0 7.4 3.3 6.2 7.4 1.5 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Epimerase PF01370.21 ELR13165.1 - 2.9e-30 105.5 0.0 3.6e-30 105.2 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 ELR13165.1 - 4.3e-07 29.6 0.0 5.2e-07 29.4 0.0 1.0 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 ELR13166.1 - 2e-30 106.0 0.0 2.8e-30 105.6 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 ELR13166.1 - 3.1e-07 30.1 0.0 4e-07 29.8 0.0 1.1 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase TPR_16 PF13432.6 ELR13167.1 - 1.5e-05 25.5 3.2 1.5e-05 25.5 3.2 4.2 3 2 2 5 5 5 1 Tetratricopeptide repeat TPR_2 PF07719.17 ELR13167.1 - 4.9e-05 23.1 5.5 0.29 11.4 0.0 4.2 4 0 0 4 4 4 2 Tetratricopeptide repeat ANAPC3 PF12895.7 ELR13167.1 - 0.00013 22.1 7.3 0.17 12.1 0.2 3.7 2 1 1 3 3 3 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_1 PF00515.28 ELR13167.1 - 0.00029 20.5 0.1 0.46 10.4 0.0 3.2 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_17 PF13431.6 ELR13167.1 - 0.025 14.9 0.0 6.2 7.5 0.0 3.2 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_14 PF13428.6 ELR13167.1 - 0.086 13.7 0.1 0.086 13.7 0.1 4.6 3 2 1 4 4 4 0 Tetratricopeptide repeat TPR_8 PF13181.6 ELR13167.1 - 0.099 12.9 2.1 8.4 6.9 0.1 3.5 4 0 0 4 4 4 0 Tetratricopeptide repeat DUF5063 PF16702.5 ELR13169.1 - 0.12 12.8 2.1 0.22 11.9 2.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF5063) Beta-lactamase PF00144.24 ELR13170.1 - 2.8e-36 125.4 0.1 4.9e-36 124.6 0.1 1.3 1 1 0 1 1 1 1 Beta-lactamase Glug PF07581.12 ELR13170.1 - 0.081 13.4 0.2 0.31 11.6 0.2 2.1 1 0 0 1 1 1 0 The GLUG motif Sua5_yciO_yrdC PF01300.18 ELR13171.1 - 2.6e-56 190.0 0.0 3.5e-56 189.5 0.0 1.2 1 0 0 1 1 1 1 Telomere recombination SUA5 PF03481.13 ELR13171.1 - 4.7e-28 98.4 0.0 7.8e-28 97.7 0.0 1.4 1 0 0 1 1 1 1 Putative GTP-binding controlling metal-binding DUF3842 PF12953.7 ELR13171.1 - 0.19 12.1 0.6 23 5.4 0.0 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF3842) HEAT_2 PF13646.6 ELR13172.1 - 3.7e-16 59.3 14.3 0.26 11.7 0.0 10.2 7 3 6 13 13 13 9 HEAT repeats HEAT PF02985.22 ELR13172.1 - 2.7e-10 39.6 12.9 0.37 11.2 0.1 9.0 10 0 0 10 10 9 3 HEAT repeat AAA_16 PF13191.6 ELR13172.1 - 5.8e-08 33.3 0.2 5.8e-08 33.3 0.2 3.6 4 0 0 4 4 4 1 AAA ATPase domain Adaptin_N PF01602.20 ELR13172.1 - 1.1e-05 24.2 6.6 2.2e-05 23.3 0.3 4.1 5 0 0 5 5 5 1 Adaptin N terminal region AAA_22 PF13401.6 ELR13172.1 - 1.6e-05 25.2 0.0 0.0017 18.6 0.0 2.9 2 0 0 2 2 2 1 AAA domain HEAT_EZ PF13513.6 ELR13172.1 - 0.00037 20.9 10.2 3.2 8.3 0.0 7.6 8 0 0 8 8 7 1 HEAT-like repeat Arm PF00514.23 ELR13172.1 - 0.00085 19.3 4.5 0.14 12.3 0.0 5.2 5 0 0 5 5 4 1 Armadillo/beta-catenin-like repeat NACHT PF05729.12 ELR13172.1 - 0.0016 18.3 0.0 0.011 15.6 0.0 2.4 1 1 0 1 1 1 1 NACHT domain NB-ARC PF00931.22 ELR13172.1 - 0.092 11.9 0.0 0.31 10.2 0.0 1.8 2 0 0 2 2 2 0 NB-ARC domain MID_MedPIWI PF18296.1 ELR13172.1 - 0.22 11.3 2.6 0.83 9.4 2.6 1.9 1 0 0 1 1 1 0 MID domain of medPIWI Cohesin_HEAT PF12765.7 ELR13172.1 - 0.48 10.8 2.7 8.5 6.8 0.1 3.6 3 0 0 3 3 3 0 HEAT repeat associated with sister chromatid cohesion SRP-alpha_N PF04086.13 ELR13172.1 - 0.72 9.7 9.0 3.5 7.4 8.3 2.5 2 0 0 2 2 2 0 Signal recognition particle, alpha subunit, N-terminal Macoilin PF09726.9 ELR13172.1 - 0.96 7.9 4.7 2.3 6.7 4.7 1.5 1 0 0 1 1 1 0 Macoilin family TMEM144 PF07857.12 ELR13173.1 - 3.2e-87 292.6 1.8 3.2e-85 286.1 1.8 2.0 1 1 0 1 1 1 1 Transmembrane family, TMEM144 of transporters Mannosyl_trans PF05007.13 ELR13173.1 - 0.49 10.2 4.2 0.4 10.5 0.5 2.0 2 0 0 2 2 2 0 Mannosyltransferase (PIG-M) DMT_YdcZ PF04657.13 ELR13173.1 - 3 8.1 19.6 0.09 13.1 10.6 2.5 2 1 0 2 2 2 0 Putative inner membrane exporter, YdcZ DotU PF09850.9 ELR13176.1 - 0.021 14.6 0.4 0.027 14.2 0.4 1.2 1 0 0 1 1 1 0 Type VI secretion system protein DotU RskA PF10099.9 ELR13176.1 - 0.032 14.5 0.1 0.033 14.5 0.1 1.1 1 0 0 1 1 1 0 Anti-sigma-K factor rskA Aldo_ket_red PF00248.21 ELR13177.1 - 6.5e-34 117.5 0.0 7.5e-34 117.3 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family PBSX_XtrA PF17356.2 ELR13178.1 - 0.047 13.6 0.1 0.094 12.6 0.1 1.5 1 0 0 1 1 1 0 Phage-like element PBSX protein XtrA PAS_3 PF08447.12 ELR13180.1 - 1.6e-05 25.1 0.0 3.6e-05 24.0 0.0 1.6 1 0 0 1 1 1 1 PAS fold PAS PF00989.25 ELR13180.1 - 2e-05 24.6 0.0 4e-05 23.6 0.0 1.4 1 0 0 1 1 1 1 PAS fold DUF4763 PF15960.5 ELR13180.1 - 0.0018 17.6 5.2 0.0031 16.8 5.2 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4763) PAS_9 PF13426.7 ELR13180.1 - 0.0023 18.1 0.0 0.0041 17.3 0.0 1.5 1 0 0 1 1 1 1 PAS domain TMF_TATA_bd PF12325.8 ELR13180.1 - 0.0032 17.7 1.6 0.0056 16.9 1.6 1.4 1 0 0 1 1 1 1 TATA element modulatory factor 1 TATA binding NRBF2 PF08961.10 ELR13180.1 - 0.018 14.6 0.4 0.039 13.6 0.4 1.5 1 0 0 1 1 1 0 Nuclear receptor-binding factor 2, autophagy regulator YabA PF06156.13 ELR13180.1 - 0.089 13.4 1.3 0.16 12.7 1.3 1.3 1 0 0 1 1 1 0 Initiation control protein YabA Lebercilin PF15619.6 ELR13180.1 - 0.16 11.6 5.7 0.23 11.1 5.7 1.2 1 0 0 1 1 1 0 Ciliary protein causing Leber congenital amaurosis disease bZIP_1 PF00170.21 ELR13180.1 - 0.17 12.0 1.8 0.3 11.2 1.8 1.4 1 0 0 1 1 1 0 bZIP transcription factor Sporozoite_P67 PF05642.11 ELR13180.1 - 0.18 9.8 2.3 0.25 9.4 2.3 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen ZapB PF06005.12 ELR13180.1 - 0.22 12.0 3.9 0.39 11.2 3.9 1.4 1 0 0 1 1 1 0 Cell division protein ZapB FlaC_arch PF05377.11 ELR13180.1 - 0.27 11.7 0.8 0.48 10.8 0.8 1.4 1 0 0 1 1 1 0 Flagella accessory protein C (FlaC) DAP_epimerase PF01678.19 ELR13181.1 - 3.4e-44 149.9 0.0 1.1e-20 74.0 0.0 2.4 2 1 0 2 2 2 2 Diaminopimelate epimerase MFS_1 PF07690.16 ELR13182.1 - 1e-32 113.4 46.6 7.2e-19 67.9 11.1 3.0 2 1 1 3 3 3 3 Major Facilitator Superfamily Sugar_tr PF00083.24 ELR13182.1 - 5.8e-11 41.9 1.3 5.8e-11 41.9 1.3 3.1 2 1 1 3 3 3 1 Sugar (and other) transporter MFS_3 PF05977.13 ELR13182.1 - 8.5e-05 21.1 2.4 0.00015 20.3 2.4 1.4 1 0 0 1 1 1 1 Transmembrane secretion effector TRI12 PF06609.13 ELR13182.1 - 0.00082 17.9 0.8 0.00082 17.9 0.8 1.8 2 1 1 3 3 3 1 Fungal trichothecene efflux pump (TRI12) NmrA PF05368.13 ELR13183.1 - 4.8e-17 62.3 0.0 6.4e-17 61.9 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 ELR13183.1 - 2e-16 60.4 0.0 3.1e-16 59.8 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 ELR13183.1 - 1.8e-05 24.4 0.0 3.1e-05 23.6 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family TrkA_N PF02254.18 ELR13183.1 - 0.0023 18.2 0.0 0.005 17.1 0.0 1.5 1 0 0 1 1 1 1 TrkA-N domain Sacchrp_dh_NADP PF03435.18 ELR13183.1 - 0.054 13.8 0.0 0.13 12.6 0.0 1.6 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain ABC2_membrane PF01061.24 ELR13185.1 - 6e-44 150.0 13.1 6e-44 150.0 13.1 2.0 2 0 0 2 2 2 1 ABC-2 type transporter ABC_tran PF00005.27 ELR13185.1 - 4.3e-26 92.1 0.0 7.6e-26 91.2 0.0 1.4 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 ELR13185.1 - 5.2e-08 33.0 0.0 5.4e-05 23.2 0.0 2.3 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system RsgA_GTPase PF03193.16 ELR13185.1 - 1.9e-05 24.6 0.2 4.2e-05 23.5 0.2 1.5 1 0 0 1 1 1 1 RsgA GTPase ABC2_membrane_3 PF12698.7 ELR13185.1 - 0.00064 18.9 14.7 0.00064 18.9 14.7 1.5 1 1 0 1 1 1 1 ABC-2 family transporter protein AAA_22 PF13401.6 ELR13185.1 - 0.0015 18.8 0.1 0.0067 16.7 0.1 2.1 1 1 0 1 1 1 1 AAA domain cobW PF02492.19 ELR13185.1 - 0.0026 17.4 0.4 0.0057 16.3 0.4 1.5 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain MMR_HSR1 PF01926.23 ELR13185.1 - 0.0043 17.1 0.1 0.0089 16.1 0.1 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_23 PF13476.6 ELR13185.1 - 0.0066 17.0 0.7 0.014 15.9 0.7 1.5 1 0 0 1 1 1 1 AAA domain AAA_24 PF13479.6 ELR13185.1 - 0.0072 16.1 0.0 0.014 15.1 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_25 PF13481.6 ELR13185.1 - 0.013 15.1 0.6 0.031 13.8 0.1 1.8 2 0 0 2 2 2 0 AAA domain SMC_N PF02463.19 ELR13185.1 - 0.014 14.8 0.0 0.24 10.8 0.0 2.2 1 1 0 1 1 1 0 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 ELR13185.1 - 0.022 14.5 0.2 0.051 13.3 0.2 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_16 PF13191.6 ELR13185.1 - 0.035 14.5 0.1 0.09 13.1 0.1 1.6 1 0 0 1 1 1 0 AAA ATPase domain Septin PF00735.18 ELR13185.1 - 0.13 11.5 0.0 0.24 10.6 0.0 1.3 1 0 0 1 1 1 0 Septin NACHT PF05729.12 ELR13185.1 - 0.14 12.1 0.3 0.3 11.0 0.3 1.6 1 0 0 1 1 1 0 NACHT domain MobB PF03205.14 ELR13185.1 - 0.16 11.8 0.2 0.39 10.6 0.2 1.6 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B ABC2_membrane_2 PF12679.7 ELR13185.1 - 0.54 9.5 8.9 1.1 8.5 8.9 1.4 1 0 0 1 1 1 0 ABC-2 family transporter protein Ras PF00071.22 ELR13186.1 - 4.4e-48 163.0 0.0 8.1e-26 90.5 0.0 2.0 2 0 0 2 2 2 2 Ras family Roc PF08477.13 ELR13186.1 - 2.7e-19 69.5 0.0 7.8e-12 45.5 0.0 2.3 1 1 1 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR13186.1 - 3.6e-08 33.1 0.0 6.1e-05 22.5 0.0 2.1 2 0 0 2 2 2 2 ADP-ribosylation factor family DUF4448 PF14610.6 ELR13188.1 - 0.064 13.0 0.0 0.064 13.0 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF4448) Rax2 PF12768.7 ELR13188.1 - 0.16 11.4 0.1 0.29 10.6 0.1 1.5 1 0 0 1 1 1 0 Cortical protein marker for cell polarity S4 PF01479.25 ELR13189.1 - 0.013 15.2 0.0 0.022 14.5 0.0 1.4 1 0 0 1 1 1 0 S4 domain PseudoU_synth_2 PF00849.22 ELR13190.1 - 2.9e-12 46.9 0.0 4.8e-12 46.3 0.0 1.3 1 1 0 1 1 1 1 RNA pseudouridylate synthase RsgA_N PF16745.5 ELR13190.1 - 0.19 11.5 0.5 21 5.0 0.1 2.3 2 0 0 2 2 2 0 RsgA N-terminal domain ANAPC4_WD40 PF12894.7 ELR13191.1 - 3.8e-15 55.9 3.7 0.002 18.4 0.0 6.8 4 2 4 8 8 8 4 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 ELR13191.1 - 1.6e-11 44.6 9.0 0.00092 20.0 0.0 7.6 7 1 0 7 7 7 2 WD domain, G-beta repeat eIF2A PF08662.11 ELR13191.1 - 4.1e-09 36.6 0.1 0.013 15.4 0.0 5.2 3 2 1 4 4 4 3 Eukaryotic translation initiation factor eIF2A PD40 PF07676.12 ELR13191.1 - 0.00096 19.0 4.6 14 5.7 0.0 5.6 6 0 0 6 6 6 1 WD40-like Beta Propeller Repeat DPPIV_N PF00930.21 ELR13191.1 - 0.015 14.0 1.2 7.8 5.1 0.0 4.1 3 1 0 4 4 4 0 Dipeptidyl peptidase IV (DPP IV) N-terminal region IKI3 PF04762.12 ELR13191.1 - 0.05 11.6 2.3 3.4 5.5 0.0 3.6 2 2 2 4 4 4 0 IKI3 family DAGK_acc PF00609.19 ELR13192.1 - 2.3e-40 138.6 0.0 3.9e-40 137.8 0.0 1.4 1 0 0 1 1 1 1 Diacylglycerol kinase accessory domain DAGK_cat PF00781.24 ELR13192.1 - 2.1e-25 88.8 0.0 1.6e-24 85.9 0.0 2.5 2 0 0 2 2 2 1 Diacylglycerol kinase catalytic domain Epimerase PF01370.21 ELR13193.1 - 6.3e-20 71.7 0.0 1e-19 71.0 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 ELR13193.1 - 8.6e-11 41.4 0.0 1.6e-09 37.2 0.0 2.2 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.6 ELR13193.1 - 1.6e-08 34.7 0.0 4.2e-08 33.3 0.0 1.6 1 1 0 1 1 1 1 NAD(P)H-binding GDP_Man_Dehyd PF16363.5 ELR13193.1 - 2.6e-08 33.7 0.0 8.4e-08 32.0 0.0 1.8 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase RmlD_sub_bind PF04321.17 ELR13193.1 - 9e-05 21.7 0.0 0.00012 21.3 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain NmrA PF05368.13 ELR13193.1 - 0.0064 16.1 0.0 0.011 15.3 0.0 1.4 1 0 0 1 1 1 1 NmrA-like family Dicty_CAD PF05720.12 ELR13193.1 - 0.067 13.2 0.0 0.15 12.1 0.0 1.5 1 0 0 1 1 1 0 Cell-cell adhesion domain Sacchrp_dh_NADP PF03435.18 ELR13193.1 - 0.075 13.3 0.0 0.3 11.3 0.0 2.0 1 1 1 2 2 2 0 Saccharopine dehydrogenase NADP binding domain Pox_A_type_inc PF04508.12 ELR13193.1 - 0.11 12.3 0.0 0.24 11.3 0.0 1.5 1 0 0 1 1 1 0 Viral A-type inclusion protein repeat WD40 PF00400.32 ELR13194.1 - 4.1e-23 81.2 14.0 3.5e-07 30.8 0.1 6.5 7 0 0 7 7 7 4 WD domain, G-beta repeat F-box-like PF12937.7 ELR13194.1 - 5.3e-07 29.4 0.5 1e-06 28.5 0.5 1.5 1 0 0 1 1 1 1 F-box-like ANAPC4_WD40 PF12894.7 ELR13194.1 - 1.1e-05 25.6 0.5 0.97 9.8 0.0 4.8 1 1 4 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain F-box PF00646.33 ELR13194.1 - 0.00041 20.1 0.0 0.0011 18.8 0.0 1.7 1 0 0 1 1 1 1 F-box domain Nup160 PF11715.8 ELR13194.1 - 0.0061 15.3 2.0 0.46 9.1 0.1 2.9 1 1 0 2 2 2 2 Nucleoporin Nup120/160 WD40_like PF17005.5 ELR13194.1 - 0.0065 15.8 0.0 0.019 14.3 0.0 1.8 2 0 0 2 2 2 1 WD40-like domain F-box_5 PF18511.1 ELR13194.1 - 0.0092 15.5 0.2 0.022 14.3 0.2 1.6 1 0 0 1 1 1 1 F-box F-box_4 PF15966.5 ELR13194.1 - 0.029 14.2 1.9 0.077 12.9 0.2 2.5 3 1 0 3 3 3 0 F-box Nucleoporin_N PF08801.11 ELR13194.1 - 0.11 11.2 0.0 1.5 7.4 0.0 2.4 3 0 0 3 3 3 0 Nup133 N terminal like NT5C PF06941.12 ELR13195.1 - 0.0066 16.3 0.0 0.012 15.5 0.0 1.4 1 0 0 1 1 1 1 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C) HAD_SAK_2 PF18143.1 ELR13195.1 - 0.024 14.9 0.2 0.85 9.9 0.0 2.2 2 0 0 2 2 2 0 HAD domain in Swiss Army Knife RNA repair proteins MORN PF02493.20 ELR13197.1 - 3.7e-24 83.1 30.7 2.2e-05 24.0 6.7 5.4 5 0 0 5 5 5 5 MORN repeat F-box-like PF12937.7 ELR13197.1 - 2.3e-06 27.4 1.8 3.9e-06 26.7 1.8 1.4 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ELR13197.1 - 0.00077 19.3 1.6 0.0015 18.3 0.7 1.9 2 0 0 2 2 2 1 F-box domain DUF3048_C PF17479.2 ELR13197.1 - 0.39 11.1 9.7 8 6.9 0.1 3.6 1 1 3 4 4 4 0 Protein of unknown function (DUF3048) C-terminal domain Zip PF02535.22 ELR13198.1 - 1.2e-56 192.3 10.4 1.2e-56 192.3 10.4 4.0 2 2 0 2 2 2 1 ZIP Zinc transporter EF-hand_1 PF00036.32 ELR13198.1 - 2.9e-09 35.8 0.6 0.0015 18.0 0.1 2.7 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 ELR13198.1 - 6.3e-07 29.8 1.4 0.02 15.3 1.6 3.0 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 ELR13198.1 - 1.9e-06 27.4 5.7 0.024 14.5 0.1 3.3 3 0 0 3 3 3 2 EF-hand domain SPARC_Ca_bdg PF10591.9 ELR13198.1 - 0.00028 21.2 2.8 0.032 14.6 1.4 2.9 2 0 0 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_5 PF13202.6 ELR13198.1 - 0.00041 19.7 0.8 0.012 15.1 0.2 2.5 2 0 0 2 2 2 1 EF hand EF-hand_8 PF13833.6 ELR13198.1 - 0.031 14.1 1.6 2.1 8.3 0.1 2.5 2 0 0 2 2 2 0 EF-hand domain pair Choline_transpo PF04515.12 ELR13198.1 - 0.033 13.4 0.7 0.097 11.9 0.7 1.7 1 0 0 1 1 1 0 Plasma-membrane choline transporter Yip1 PF04893.17 ELR13198.1 - 9.6 5.9 16.8 3.9 7.2 2.6 3.2 3 0 0 3 3 3 0 Yip1 domain tRNA-synt_2 PF00152.20 ELR13199.1 - 1.5e-42 145.8 0.0 2.3e-42 145.2 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) cwf21 PF08312.12 ELR13199.1 - 0.036 14.2 0.6 0.095 12.9 0.6 1.7 1 0 0 1 1 1 0 cwf21 domain FMO-like PF00743.19 ELR13200.1 - 8.7e-66 222.4 0.0 1.9e-65 221.3 0.0 1.6 1 1 0 1 1 1 1 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 ELR13200.1 - 5.7e-09 35.6 0.0 3.5e-05 23.2 0.0 3.2 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 ELR13200.1 - 4e-07 29.6 0.0 2.9e-06 26.7 0.0 1.9 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 ELR13200.1 - 1.8e-06 27.4 0.1 0.0001 21.6 0.0 2.9 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_8 PF13450.6 ELR13200.1 - 0.00011 22.4 0.4 0.00069 19.8 0.0 2.4 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 ELR13200.1 - 0.0014 18.2 0.1 0.76 9.3 0.0 3.0 2 1 1 3 3 3 1 FAD dependent oxidoreductase NAD_binding_7 PF13241.6 ELR13200.1 - 0.0015 18.9 0.3 1.2 9.6 0.1 3.3 2 2 0 2 2 2 1 Putative NAD(P)-binding NAD_binding_9 PF13454.6 ELR13200.1 - 0.014 15.4 0.0 0.079 12.9 0.0 2.3 2 1 0 2 2 2 0 FAD-NAD(P)-binding Shikimate_DH PF01488.20 ELR13200.1 - 0.14 12.2 0.0 12 5.9 0.0 2.7 3 0 0 3 3 3 0 Shikimate / quinate 5-dehydrogenase Exonuc_VII_L PF02601.15 ELR13201.1 - 0.0037 16.9 0.0 0.0074 15.9 0.0 1.5 1 1 0 1 1 1 1 Exonuclease VII, large subunit PAS PF00989.25 ELR13201.1 - 0.0068 16.4 0.9 0.014 15.4 0.0 1.9 2 0 0 2 2 2 1 PAS fold PAS_9 PF13426.7 ELR13201.1 - 0.0081 16.4 0.0 0.017 15.4 0.0 1.5 1 0 0 1 1 1 1 PAS domain PAS_8 PF13188.7 ELR13201.1 - 0.045 13.8 0.0 0.12 12.5 0.0 1.6 1 0 0 1 1 1 0 PAS domain PAS_3 PF08447.12 ELR13201.1 - 0.045 14.0 0.0 0.13 12.6 0.0 1.8 1 1 0 1 1 1 0 PAS fold DUF4665 PF15679.5 ELR13201.1 - 1.6 9.4 6.8 3.5 8.3 6.8 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4665) V_ATPase_I PF01496.19 ELR13201.1 - 8.8 4.1 8.5 15 3.3 8.5 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family ALMT PF11744.8 ELR13201.1 - 9.3 5.0 6.5 17 4.1 6.5 1.3 1 0 0 1 1 1 0 Aluminium activated malate transporter PAS_9 PF13426.7 ELR13202.1 - 0.00066 19.9 0.0 0.0019 18.4 0.0 1.8 1 0 0 1 1 1 1 PAS domain PAS PF00989.25 ELR13202.1 - 0.05 13.6 0.0 0.12 12.3 0.0 1.6 1 0 0 1 1 1 0 PAS fold DUF1640 PF07798.11 ELR13202.1 - 0.073 13.1 3.3 0.1 12.6 3.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1640) Prominin PF05478.11 ELR13202.1 - 0.074 11.0 1.0 0.1 10.6 1.0 1.1 1 0 0 1 1 1 0 Prominin DUF4763 PF15960.5 ELR13202.1 - 0.086 12.1 6.1 0.12 11.7 2.3 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4763) GET2 PF08690.10 ELR13202.1 - 0.6 9.7 6.8 0.28 10.8 1.8 2.1 2 0 0 2 2 2 0 GET complex subunit GET2 Atg14 PF10186.9 ELR13202.1 - 0.72 8.9 7.5 1 8.4 7.5 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 APG6_N PF17675.1 ELR13202.1 - 1 9.9 9.5 0.72 10.4 8.0 1.5 1 1 0 1 1 1 0 Apg6 coiled-coil region PRKG1_interact PF15898.5 ELR13202.1 - 1.3 10.0 10.8 0.15 12.9 5.9 1.8 2 0 0 2 2 2 0 cGMP-dependent protein kinase interacting domain UPF0242 PF06785.11 ELR13202.1 - 4.2 7.4 8.2 1.8 8.6 5.8 1.6 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Macoilin PF09726.9 ELR13202.1 - 5.3 5.5 8.4 7.7 4.9 8.4 1.2 1 0 0 1 1 1 0 Macoilin family SAP PF02037.27 ELR13204.1 - 1.8e-08 33.9 6.8 0.0013 18.4 1.0 4.6 4 0 0 4 4 4 4 SAP domain SANTA PF09133.10 ELR13204.1 - 4.3e-05 23.9 0.2 0.00018 22.0 0.0 2.1 2 0 0 2 2 2 1 SANTA (SANT Associated) HGTP_anticodon PF03129.20 ELR13205.1 - 3.9e-20 71.8 0.1 1.1e-19 70.4 0.0 1.8 2 0 0 2 2 2 1 Anticodon binding domain tRNA-synt_2b PF00587.25 ELR13205.1 - 3.7e-14 53.1 0.0 1.7e-13 50.9 0.0 1.9 2 0 0 2 2 2 1 tRNA synthetase class II core domain (G, H, P, S and T) Peptidase_S24 PF00717.23 ELR13206.1 - 4.7e-09 36.1 0.1 7.1e-09 35.5 0.1 1.3 1 0 0 1 1 1 1 Peptidase S24-like Peptidase_S26 PF10502.9 ELR13206.1 - 0.005 16.6 0.0 2.5 7.9 0.0 2.3 1 1 1 2 2 2 2 Signal peptidase, peptidase S26 RasGAP PF00616.19 ELR13207.1 - 8.1e-25 87.8 0.0 1.3e-24 87.1 0.0 1.3 1 0 0 1 1 1 1 GTPase-activator protein for Ras-like GTPase Laminin_G_3 PF13385.6 ELR13207.1 - 1.2e-06 28.8 5.6 0.00038 20.6 2.4 2.9 2 1 1 3 3 3 2 Concanavalin A-like lectin/glucanases superfamily Ig_3 PF13927.6 ELR13207.1 - 0.0014 19.2 0.1 0.0064 17.1 0.1 2.2 1 1 0 1 1 1 1 Immunoglobulin domain Gly-zipper_Omp PF13488.6 ELR13207.1 - 0.22 11.6 4.4 0.46 10.5 4.4 1.5 1 0 0 1 1 1 0 Glycine zipper Beta-APP PF03494.13 ELR13207.1 - 1.1 9.2 3.5 2.6 8.0 3.5 1.6 1 0 0 1 1 1 0 Beta-amyloid peptide (beta-APP) p450 PF00067.22 ELR13208.1 - 2.3e-95 320.1 0.0 3.1e-95 319.6 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 ABC_tran PF00005.27 ELR13209.1 - 1.9e-45 154.8 0.0 3.6e-29 102.0 0.0 2.9 2 1 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 ELR13209.1 - 1.1e-34 120.4 9.7 1.7e-28 100.1 1.9 2.3 2 0 0 2 2 2 2 ABC transporter transmembrane region SMC_N PF02463.19 ELR13209.1 - 7.4e-10 38.6 0.8 0.0098 15.3 0.0 4.2 2 2 0 3 3 3 2 RecF/RecN/SMC N terminal domain Dynamin_N PF00350.23 ELR13209.1 - 8.4e-09 35.7 1.0 0.00069 19.7 0.0 2.8 3 0 0 3 3 2 2 Dynamin family MMR_HSR1 PF01926.23 ELR13209.1 - 2.3e-08 34.1 3.2 0.00051 20.1 0.1 3.4 3 0 0 3 3 3 2 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 ELR13209.1 - 4.3e-07 30.0 0.3 0.026 14.4 0.0 2.4 2 0 0 2 2 2 2 RsgA GTPase AAA_16 PF13191.6 ELR13209.1 - 7.1e-07 29.8 0.4 0.034 14.5 0.0 3.1 2 1 0 2 2 2 2 AAA ATPase domain AAA_29 PF13555.6 ELR13209.1 - 2.5e-05 23.9 0.1 0.1 12.3 0.0 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain MDM31_MDM32 PF08118.11 ELR13209.1 - 4.2e-05 22.4 0.2 5.8e-05 22.0 0.2 1.2 1 0 0 1 1 1 1 Yeast mitochondrial distribution and morphology (MDM) proteins AAA_22 PF13401.6 ELR13209.1 - 6.9e-05 23.1 0.5 0.49 10.7 0.0 3.3 3 0 0 3 3 3 2 AAA domain AAA_7 PF12775.7 ELR13209.1 - 0.00023 20.7 0.2 0.46 10.0 0.0 2.3 2 0 0 2 2 2 2 P-loop containing dynein motor region T2SSE PF00437.20 ELR13209.1 - 0.00052 19.2 0.0 0.74 8.8 0.0 2.3 2 0 0 2 2 2 2 Type II/IV secretion system protein SbcCD_C PF13558.6 ELR13209.1 - 0.00066 19.9 0.0 1.6 9.0 0.0 3.1 3 0 0 3 3 2 1 Putative exonuclease SbcCD, C subunit AAA_21 PF13304.6 ELR13209.1 - 0.0012 18.7 2.5 0.98 9.2 0.2 3.3 2 1 0 3 3 3 1 AAA domain, putative AbiEii toxin, Type IV TA system FtsK_SpoIIIE PF01580.18 ELR13209.1 - 0.0046 16.3 0.0 2.4 7.5 0.0 2.3 2 0 0 2 2 2 1 FtsK/SpoIIIE family AIG1 PF04548.16 ELR13209.1 - 0.005 16.2 1.7 2.1 7.7 0.2 2.5 2 0 0 2 2 2 2 AIG1 family AAA_23 PF13476.6 ELR13209.1 - 0.005 17.4 0.0 0.71 10.3 0.0 2.5 2 0 0 2 2 2 1 AAA domain Roc PF08477.13 ELR13209.1 - 0.0091 16.2 0.3 5.8 7.2 0.1 2.6 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase Septin PF00735.18 ELR13209.1 - 0.0095 15.2 0.2 2.2 7.5 0.0 2.3 2 0 0 2 2 2 1 Septin cobW PF02492.19 ELR13209.1 - 0.01 15.5 2.5 0.33 10.5 0.2 2.4 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain IIGP PF05049.13 ELR13209.1 - 0.01 14.9 0.2 0.068 12.2 0.0 2.0 2 0 0 2 2 2 0 Interferon-inducible GTPase (IIGP) FHIPEP PF00771.20 ELR13209.1 - 0.01 14.3 0.0 0.022 13.2 0.0 1.4 1 0 0 1 1 1 0 FHIPEP family Zeta_toxin PF06414.12 ELR13209.1 - 0.015 14.5 0.1 3.9 6.7 0.0 2.6 2 0 0 2 2 2 0 Zeta toxin KAP_NTPase PF07693.14 ELR13209.1 - 0.016 14.4 0.0 1.2 8.3 0.0 2.3 2 0 0 2 2 2 0 KAP family P-loop domain AAA_24 PF13479.6 ELR13209.1 - 0.018 14.8 0.3 1 9.0 0.0 2.8 2 1 0 2 2 2 0 AAA domain NB-ARC PF00931.22 ELR13209.1 - 0.02 14.1 0.1 1.6 7.8 0.0 2.5 2 0 0 2 2 2 0 NB-ARC domain FeoB_N PF02421.18 ELR13209.1 - 0.032 13.8 0.2 3.5 7.1 0.0 2.4 2 0 0 2 2 2 0 Ferrous iron transport protein B AAA PF00004.29 ELR13209.1 - 0.049 14.0 1.2 11 6.5 0.0 3.6 4 0 0 4 4 3 0 ATPase family associated with various cellular activities (AAA) NACHT PF05729.12 ELR13209.1 - 0.062 13.2 0.1 2.1 8.3 0.0 2.5 2 0 0 2 2 2 0 NACHT domain AAA_25 PF13481.6 ELR13209.1 - 0.07 12.7 0.0 0.46 10.0 0.0 2.2 2 0 0 2 2 2 0 AAA domain TsaE PF02367.17 ELR13209.1 - 0.075 13.0 0.1 5.3 7.1 0.0 2.4 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE DUF87 PF01935.17 ELR13209.1 - 0.075 13.1 3.7 0.11 12.5 0.4 2.2 2 0 0 2 2 2 0 Helicase HerA, central domain PduV-EutP PF10662.9 ELR13209.1 - 0.11 12.2 0.1 5.3 6.8 0.0 2.4 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation GTP_EFTU PF00009.27 ELR13209.1 - 0.13 11.8 2.2 8.2 5.9 0.0 3.3 3 0 0 3 3 3 0 Elongation factor Tu GTP binding domain ABC_ATPase PF09818.9 ELR13209.1 - 0.15 10.8 0.3 2.2 7.0 0.0 2.6 3 0 0 3 3 3 0 Predicted ATPase of the ABC class ATP_bind_1 PF03029.17 ELR13209.1 - 0.18 11.5 0.3 18 5.0 0.1 2.4 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein AAA_15 PF13175.6 ELR13209.1 - 0.21 11.3 0.0 19 4.8 0.0 2.2 2 0 0 2 2 2 0 AAA ATPase domain TrwB_AAD_bind PF10412.9 ELR13209.1 - 0.24 10.3 1.0 6 5.7 0.1 2.3 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain ABC_membrane PF00664.23 ELR13210.1 - 0.0042 16.8 3.0 0.0053 16.5 3.0 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region IPTL-CTERM PF18203.1 ELR13210.1 - 0.13 12.2 0.4 0.13 12.2 0.4 2.8 4 0 0 4 4 4 0 IPTL-CTERM motif LRR_6 PF13516.6 ELR13211.1 - 5.3e-07 29.2 22.5 2.1 8.6 0.0 10.9 11 1 1 12 12 12 4 Leucine Rich repeat LRR_4 PF12799.7 ELR13211.1 - 7.7e-05 23.0 7.6 3.5 8.2 0.5 5.6 3 1 3 6 6 6 2 Leucine Rich repeats (2 copies) Recep_L_domain PF01030.24 ELR13211.1 - 0.0043 17.1 0.1 1.1 9.4 0.0 2.6 2 0 0 2 2 2 2 Receptor L domain LRR_1 PF00560.33 ELR13211.1 - 4.1 8.3 13.9 1.1e+02 4.0 0.1 7.6 9 2 0 9 9 9 0 Leucine Rich Repeat Arm PF00514.23 ELR13212.1 - 1.8e-16 59.6 12.3 1.2e-05 25.2 0.2 8.2 8 0 0 8 8 8 3 Armadillo/beta-catenin-like repeat zf-C3HC4_3 PF13920.6 ELR13212.1 - 1.1e-11 44.5 13.7 1.9e-11 43.6 13.7 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) HEAT_2 PF13646.6 ELR13212.1 - 2.5e-05 24.6 7.0 0.045 14.1 0.0 3.7 3 3 0 3 3 3 2 HEAT repeats HEAT PF02985.22 ELR13212.1 - 0.0015 18.6 0.3 0.51 10.7 0.1 3.9 4 0 0 4 4 4 1 HEAT repeat zf-RING_2 PF13639.6 ELR13212.1 - 0.028 14.7 13.3 0.072 13.4 13.3 1.8 1 0 0 1 1 1 0 Ring finger domain HEAT_EZ PF13513.6 ELR13212.1 - 0.036 14.6 5.7 12 6.5 0.8 4.4 3 1 1 4 4 4 0 HEAT-like repeat zf-RING_5 PF14634.6 ELR13212.1 - 0.076 13.0 10.8 0.2 11.7 10.8 1.8 1 0 0 1 1 1 0 zinc-RING finger domain Prok-RING_4 PF14447.6 ELR13212.1 - 0.28 11.1 12.9 0.59 10.0 12.9 1.6 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-P11 PF03854.14 ELR13212.1 - 0.33 10.7 7.2 0.7 9.6 7.2 1.5 1 0 0 1 1 1 0 P-11 zinc finger G-patch_2 PF12656.7 ELR13213.1 - 1.5e-20 73.0 0.0 1.5e-20 73.0 0.0 2.2 2 0 0 2 2 2 1 G-patch domain KN17_SH3 PF18131.1 ELR13213.1 - 1.6e-08 34.5 0.3 4.8e-08 33.0 0.3 1.9 1 0 0 1 1 1 1 KN17 SH3-like C-terminal domain KOW PF00467.29 ELR13213.1 - 0.00011 22.0 11.4 0.042 13.8 0.1 3.3 3 0 0 3 3 3 2 KOW motif G-patch PF01585.23 ELR13213.1 - 0.022 14.6 0.0 0.05 13.5 0.0 1.7 1 0 0 1 1 1 0 G-patch domain CDC45 PF02724.14 ELR13213.1 - 0.12 10.7 8.1 0.17 10.2 8.1 1.1 1 0 0 1 1 1 0 CDC45-like protein CENP-B_dimeris PF09026.10 ELR13213.1 - 8.9 6.8 23.6 8.2 6.9 0.1 2.9 3 0 0 3 3 3 0 Centromere protein B dimerisation domain Pyridox_ox_2 PF12900.7 ELR13214.1 - 1.1e-47 161.6 0.0 1.3e-47 161.3 0.0 1.1 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Putative_PNPOx PF01243.20 ELR13214.1 - 0.038 14.2 0.0 0.087 13.0 0.0 1.6 1 1 0 1 1 1 0 Pyridoxamine 5'-phosphate oxidase ETC_C1_NDUFA4 PF04800.12 ELR13215.1 - 0.012 15.9 4.2 0.02 15.1 4.1 1.5 1 1 0 1 1 1 0 ETC complex I subunit conserved region LRAT PF04970.13 ELR13216.1 - 8.1e-16 58.5 1.1 2.3e-14 53.8 1.1 2.1 1 1 0 1 1 1 1 Lecithin retinol acyltransferase Peptidase_C97 PF05903.14 ELR13216.1 - 0.00047 20.0 0.0 0.00079 19.3 0.0 1.3 1 0 0 1 1 1 1 PPPDE putative peptidase domain DUF778 PF05608.12 ELR13216.1 - 0.068 13.5 0.0 0.083 13.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF778) Pkinase_Tyr PF07714.17 ELR13217.1 - 2.2e-118 394.2 0.0 1.8e-63 214.3 0.0 3.3 3 0 0 3 3 3 3 Protein tyrosine kinase Pkinase PF00069.25 ELR13217.1 - 1.1e-105 352.8 0.0 1.4e-58 198.3 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain PBP_like_2 PF12849.7 ELR13217.1 - 1.9e-20 73.7 19.6 4.1e-10 39.8 12.4 2.4 2 0 0 2 2 2 2 PBP superfamily domain Guanylate_cyc PF00211.20 ELR13217.1 - 1.5e-07 31.2 0.0 4.1e-07 29.8 0.0 1.7 1 1 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain EGF_2 PF07974.13 ELR13217.1 - 0.0007 19.9 11.4 0.0014 19.0 11.4 1.5 1 0 0 1 1 1 1 EGF-like domain APH PF01636.23 ELR13217.1 - 0.006 16.5 0.2 0.13 12.1 0.0 2.2 2 0 0 2 2 2 1 Phosphotransferase enzyme family ABC1 PF03109.16 ELR13217.1 - 0.029 14.5 0.0 2.5 8.3 0.0 2.6 2 0 0 2 2 2 0 ABC1 family Haspin_kinase PF12330.8 ELR13217.1 - 0.082 11.8 0.0 0.17 10.8 0.0 1.4 1 0 0 1 1 1 0 Haspin like kinase domain DUF3718 PF12514.8 ELR13217.1 - 0.14 12.4 0.1 2.2 8.5 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3718) Pkinase_fungal PF17667.1 ELR13217.1 - 0.2 10.4 1.2 0.29 9.8 0.0 1.8 2 0 0 2 2 2 0 Fungal protein kinase hEGF PF12661.7 ELR13217.1 - 1.3 9.7 10.6 0.16 12.7 6.0 2.0 2 0 0 2 2 2 0 Human growth factor-like EGF DUF5018 PF16410.5 ELR13218.1 - 0.0093 14.7 0.0 0.77 8.4 0.0 3.0 3 0 0 3 3 3 1 Domain of unknown function (DUF5018) Lactonase PF10282.9 ELR13218.1 - 0.033 13.5 0.0 0.99 8.6 0.0 2.6 3 0 0 3 3 3 0 Lactonase, 7-bladed beta-propeller Asparaginase PF00710.20 ELR13220.1 - 1.5e-33 116.0 0.0 2.3e-33 115.4 0.0 1.3 1 0 0 1 1 1 1 Asparaginase, N-terminal Asparaginase_C PF17763.1 ELR13220.1 - 1.1e-09 38.5 0.0 2e-09 37.7 0.0 1.4 1 0 0 1 1 1 1 Glutaminase/Asparaginase C-terminal domain Ribonuc_L-PSP PF01042.21 ELR13221.1 - 9.2e-05 22.4 0.1 0.00014 21.9 0.1 1.3 1 0 0 1 1 1 1 Endoribonuclease L-PSP DUF4969 PF16339.5 ELR13221.1 - 0.11 12.9 0.4 0.24 11.8 0.4 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4969) Pkinase_Tyr PF07714.17 ELR13222.1 - 5.7e-99 330.6 0.0 6.7e-58 196.0 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 ELR13222.1 - 2.7e-91 305.6 0.0 2.2e-49 168.2 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain PBP_like_2 PF12849.7 ELR13222.1 - 7.8e-22 78.3 8.8 2.2e-15 57.1 0.2 2.3 2 0 0 2 2 2 2 PBP superfamily domain Pkinase_fungal PF17667.1 ELR13222.1 - 7.1e-07 28.3 0.0 0.00036 19.4 0.0 2.3 2 0 0 2 2 2 2 Fungal protein kinase Kdo PF06293.14 ELR13222.1 - 5.8e-06 25.8 0.0 0.049 13.0 0.0 2.5 2 0 0 2 2 2 2 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 ELR13222.1 - 4.4e-05 22.9 0.0 0.029 13.7 0.0 2.2 2 0 0 2 2 2 2 Kinase-like EGF_2 PF07974.13 ELR13222.1 - 0.00016 22.0 11.7 0.00039 20.7 11.7 1.7 1 0 0 1 1 1 1 EGF-like domain APH PF01636.23 ELR13222.1 - 0.0003 20.8 3.5 0.018 15.0 0.8 3.2 2 1 1 3 3 3 1 Phosphotransferase enzyme family FTA2 PF13095.6 ELR13222.1 - 0.0027 17.4 0.0 0.25 10.9 0.0 3.1 2 1 1 3 3 3 1 Kinetochore Sim4 complex subunit FTA2 TMEM154 PF15102.6 ELR13222.1 - 0.042 13.7 0.1 0.094 12.6 0.1 1.5 1 0 0 1 1 1 0 TMEM154 protein family EGF_Tenascin PF18720.1 ELR13222.1 - 0.25 11.5 9.7 0.65 10.1 9.7 1.7 1 0 0 1 1 1 0 Tenascin EGF domain EGF PF00008.27 ELR13222.1 - 1 9.7 4.9 2.2 8.7 4.9 1.6 1 0 0 1 1 1 0 EGF-like domain EB PF01683.18 ELR13222.1 - 5.8 7.3 7.6 15 5.9 3.1 2.4 2 0 0 2 2 2 0 EB module AAA_28 PF13521.6 ELR13223.1 - 1e-24 87.6 0.1 1.4e-24 87.2 0.1 1.2 1 0 0 1 1 1 1 AAA domain KTI12 PF08433.10 ELR13223.1 - 0.00036 20.1 0.1 0.0012 18.3 0.0 1.9 1 1 1 2 2 2 1 Chromatin associated protein KTI12 MeaB PF03308.16 ELR13223.1 - 0.00069 18.7 0.1 0.0065 15.5 0.0 2.1 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_30 PF13604.6 ELR13223.1 - 0.011 15.4 0.0 0.027 14.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain Thymidylate_kin PF02223.17 ELR13223.1 - 0.015 15.0 0.0 0.029 14.1 0.0 1.5 1 0 0 1 1 1 0 Thymidylate kinase DAP3 PF10236.9 ELR13223.1 - 0.03 13.5 0.0 0.044 12.9 0.0 1.3 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 AAA_33 PF13671.6 ELR13223.1 - 0.067 13.3 0.3 0.26 11.4 0.1 2.2 2 1 0 2 2 2 0 AAA domain APS_kinase PF01583.20 ELR13223.1 - 0.083 12.8 0.0 0.18 11.7 0.0 1.5 1 0 0 1 1 1 0 Adenylylsulphate kinase AAA_19 PF13245.6 ELR13223.1 - 0.13 12.6 0.8 0.23 11.8 0.6 1.8 1 1 0 1 1 1 0 AAA domain AAA_16 PF13191.6 ELR13223.1 - 0.13 12.6 0.1 0.26 11.6 0.1 1.8 1 1 0 1 1 1 0 AAA ATPase domain NTPase_1 PF03266.15 ELR13223.1 - 0.14 12.1 0.1 0.39 10.6 0.1 1.7 1 0 0 1 1 1 0 NTPase Pkinase_Tyr PF07714.17 ELR13224.1 - 4.4e-118 393.2 0.0 3.8e-58 196.8 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 ELR13224.1 - 6.6e-101 337.1 0.0 2.3e-49 168.2 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain PBP_like_2 PF12849.7 ELR13224.1 - 1.9e-25 90.1 11.0 7e-19 68.6 0.3 2.3 2 0 0 2 2 2 2 PBP superfamily domain Pkinase_fungal PF17667.1 ELR13224.1 - 7e-08 31.7 0.0 4.7e-05 22.4 0.0 2.3 2 0 0 2 2 2 2 Fungal protein kinase Kinase-like PF14531.6 ELR13224.1 - 7e-06 25.6 0.0 0.0054 16.1 0.0 2.2 2 0 0 2 2 2 2 Kinase-like Kdo PF06293.14 ELR13224.1 - 7.1e-06 25.5 0.0 0.047 13.0 0.0 2.4 2 0 0 2 2 2 2 Lipopolysaccharide kinase (Kdo/WaaP) family EGF_2 PF07974.13 ELR13224.1 - 2.2e-05 24.7 13.3 5.4e-05 23.5 13.3 1.7 1 0 0 1 1 1 1 EGF-like domain APH PF01636.23 ELR13224.1 - 0.00022 21.3 3.4 0.017 15.0 0.7 3.3 2 1 1 3 3 3 1 Phosphotransferase enzyme family EGF_Tenascin PF18720.1 ELR13224.1 - 0.0046 17.0 9.6 0.012 15.6 9.6 1.7 1 0 0 1 1 1 1 Tenascin EGF domain FTA2 PF13095.6 ELR13224.1 - 0.0053 16.4 0.0 0.27 10.8 0.0 2.9 2 1 1 3 3 3 1 Kinetochore Sim4 complex subunit FTA2 TMEM154 PF15102.6 ELR13224.1 - 0.0078 16.1 0.0 0.017 15.0 0.0 1.5 1 0 0 1 1 1 1 TMEM154 protein family EGF PF00008.27 ELR13224.1 - 0.19 12.0 6.0 0.42 11.0 6.0 1.6 1 0 0 1 1 1 0 EGF-like domain EB PF01683.18 ELR13224.1 - 2.2 8.6 8.7 5.6 7.3 4.1 2.4 2 0 0 2 2 2 0 EB module Laminin_EGF PF00053.24 ELR13224.1 - 5.1 7.3 7.5 11 6.2 7.5 1.5 1 0 0 1 1 1 0 Laminin EGF domain Ribonuc_L-PSP PF01042.21 ELR13225.1 - 0.0028 17.7 0.0 0.0041 17.1 0.0 1.3 1 0 0 1 1 1 1 Endoribonuclease L-PSP YccF PF03733.13 ELR13226.1 - 0.0069 17.1 0.0 0.0069 17.1 0.0 2.4 3 0 0 3 3 3 1 Inner membrane component domain Synapsin_C PF02750.14 ELR13227.1 - 2.3e-49 167.7 0.0 1.4e-47 161.8 0.0 2.1 1 1 0 1 1 1 1 Synapsin, ATP binding domain Synapsin PF02078.16 ELR13227.1 - 3.1e-20 72.3 0.0 5.9e-20 71.4 0.0 1.5 1 0 0 1 1 1 1 Synapsin, N-terminal domain ATP-grasp PF02222.22 ELR13227.1 - 0.053 13.1 0.0 0.16 11.6 0.0 1.7 1 1 0 1 1 1 0 ATP-grasp domain zf-RING_2 PF13639.6 ELR13228.1 - 1.8e-09 37.8 6.9 3.3e-09 36.9 6.9 1.5 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_3 PF13920.6 ELR13228.1 - 6.4e-07 29.1 4.9 1.1e-06 28.4 4.9 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 ELR13228.1 - 6.4e-07 29.1 5.1 1.1e-06 28.4 5.1 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 ELR13228.1 - 1.8e-06 27.7 6.0 3.1e-06 26.9 6.0 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 ELR13228.1 - 3.4e-05 23.6 5.8 6.4e-05 22.7 5.8 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-rbx1 PF12678.7 ELR13228.1 - 8.3e-05 22.8 6.3 0.00019 21.6 6.3 1.6 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_5 PF14634.6 ELR13228.1 - 0.00013 21.9 5.2 0.00022 21.1 5.2 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 ELR13228.1 - 0.0055 16.7 3.9 0.013 15.5 1.4 2.3 2 0 0 2 2 2 1 RING-type zinc-finger zf-RING_10 PF16685.5 ELR13228.1 - 0.019 15.1 3.1 0.035 14.2 3.1 1.4 1 0 0 1 1 1 0 zinc RING finger of MSL2 zf-RING_11 PF17123.5 ELR13228.1 - 0.022 14.5 2.8 0.039 13.7 2.8 1.4 1 0 0 1 1 1 0 RING-like zinc finger Baculo_IE-1 PF05290.11 ELR13228.1 - 0.05 13.5 1.3 0.08 12.9 1.3 1.2 1 0 0 1 1 1 0 Baculovirus immediate-early protein (IE-0) zf-RING_6 PF14835.6 ELR13228.1 - 0.42 10.5 2.4 0.79 9.6 2.4 1.4 1 0 0 1 1 1 0 zf-RING of BARD1-type protein zf-C3HC4_4 PF15227.6 ELR13228.1 - 1.2 9.3 6.6 3 8.1 6.6 1.7 1 1 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-RING_4 PF14570.6 ELR13228.1 - 1.7 8.5 6.1 3.4 7.5 6.1 1.6 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain Pkinase_Tyr PF07714.17 ELR13229.1 - 1.6e-122 407.8 0.0 4.7e-62 209.6 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 ELR13229.1 - 1.1e-107 359.4 0.0 2.9e-54 184.2 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain PBP_like_2 PF12849.7 ELR13229.1 - 5e-37 128.1 14.1 1.2e-21 77.6 2.3 2.3 2 0 0 2 2 2 2 PBP superfamily domain Guanylate_cyc PF00211.20 ELR13229.1 - 2.7e-11 43.4 0.0 4.6e-11 42.7 0.0 1.3 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain APH PF01636.23 ELR13229.1 - 2.4e-07 30.9 0.1 0.00016 21.7 0.0 2.8 2 0 0 2 2 2 2 Phosphotransferase enzyme family EGF_2 PF07974.13 ELR13229.1 - 0.00018 21.8 13.4 0.00036 20.8 13.4 1.5 1 0 0 1 1 1 1 EGF-like domain Haspin_kinase PF12330.8 ELR13229.1 - 0.00077 18.5 0.0 0.039 12.9 0.0 2.3 2 0 0 2 2 2 1 Haspin like kinase domain TMEM154 PF15102.6 ELR13229.1 - 0.0014 18.6 0.0 0.0041 17.0 0.0 1.7 1 0 0 1 1 1 1 TMEM154 protein family Kinase-like PF14531.6 ELR13229.1 - 0.0035 16.7 0.0 0.87 8.8 0.0 2.3 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.14 ELR13229.1 - 0.01 15.2 0.2 1.3 8.4 0.1 2.3 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family FTA2 PF13095.6 ELR13229.1 - 0.037 13.7 0.1 0.74 9.4 0.0 2.8 3 1 1 4 4 4 0 Kinetochore Sim4 complex subunit FTA2 RIO1 PF01163.22 ELR13229.1 - 0.039 13.5 0.8 4.7 6.8 0.1 2.4 2 0 0 2 2 2 0 RIO1 family Pkinase_fungal PF17667.1 ELR13229.1 - 0.049 12.4 0.0 1.1 7.9 0.0 2.2 2 0 0 2 2 2 0 Fungal protein kinase EGF PF00008.27 ELR13229.1 - 0.17 12.2 3.7 0.34 11.3 3.7 1.5 1 0 0 1 1 1 0 EGF-like domain DAG1 PF05454.11 ELR13229.1 - 0.24 10.7 0.1 0.45 9.9 0.1 1.3 1 0 0 1 1 1 0 Dystroglycan (Dystrophin-associated glycoprotein 1) Metallothio_6 PF05522.11 ELR13229.1 - 0.26 11.8 6.8 0.58 10.7 6.8 1.5 1 0 0 1 1 1 0 Metallothionein hEGF PF12661.7 ELR13229.1 - 0.53 11.0 6.8 1.2 9.9 6.8 1.7 1 0 0 1 1 1 0 Human growth factor-like EGF EGF_Tenascin PF18720.1 ELR13229.1 - 2.4 8.3 6.3 8.7 6.5 6.3 2.0 1 0 0 1 1 1 0 Tenascin EGF domain Hid1 PF12722.7 ELR13231.1 - 0.58 8.2 12.9 0.65 8.0 12.9 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Pkinase_Tyr PF07714.17 ELR13232.1 - 6.3e-57 192.8 0.0 2.4e-56 190.9 0.0 1.8 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ELR13232.1 - 1.8e-49 168.5 0.0 2.7e-49 167.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain FTA2 PF13095.6 ELR13232.1 - 0.016 14.8 0.0 0.055 13.1 0.0 1.7 1 1 1 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Laminin_EGF PF00053.24 ELR13232.1 - 0.036 14.2 0.8 0.068 13.3 0.8 1.3 1 0 0 1 1 1 0 Laminin EGF domain EGF PF00008.27 ELR13232.1 - 0.052 13.9 0.6 0.091 13.1 0.6 1.4 1 0 0 1 1 1 0 EGF-like domain HMD PF03201.16 ELR13232.1 - 0.14 12.4 0.0 0.53 10.5 0.0 1.9 2 0 0 2 2 2 0 H2-forming N5,N10-methylene-tetrahydromethanopterin dehydrogenase EGF_2 PF07974.13 ELR13232.1 - 0.27 11.6 4.1 0.56 10.6 4.1 1.5 1 0 0 1 1 1 0 EGF-like domain PBP_like_2 PF12849.7 ELR13234.1 - 1e-06 28.6 0.6 1.2e-06 28.4 0.6 1.0 1 0 0 1 1 1 1 PBP superfamily domain PBP_like_2 PF12849.7 ELR13235.1 - 1.6e-15 57.6 0.0 3.2e-15 56.5 0.0 1.4 1 1 0 1 1 1 1 PBP superfamily domain Pkinase_Tyr PF07714.17 ELR13236.1 - 1.6e-128 427.4 0.1 3.4e-64 216.6 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 ELR13236.1 - 6e-113 376.6 0.0 5.9e-58 196.3 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Guanylate_cyc PF00211.20 ELR13236.1 - 1.5e-11 44.3 0.0 3.3e-10 39.9 0.0 2.2 1 1 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain APH PF01636.23 ELR13236.1 - 3.2e-08 33.8 0.2 4.4e-05 23.5 0.0 2.7 2 0 0 2 2 2 2 Phosphotransferase enzyme family Haspin_kinase PF12330.8 ELR13236.1 - 9.2e-06 24.8 0.1 0.0021 17.1 0.1 2.2 2 0 0 2 2 2 2 Haspin like kinase domain Kinase-like PF14531.6 ELR13236.1 - 1.2e-05 24.8 0.0 0.019 14.3 0.0 2.7 3 0 0 3 3 3 2 Kinase-like Kdo PF06293.14 ELR13236.1 - 4.1e-05 23.0 0.4 0.094 12.0 0.1 2.4 2 0 0 2 2 2 2 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 ELR13236.1 - 0.0017 18.0 0.8 1.4 8.4 0.1 2.4 2 0 0 2 2 2 2 RIO1 family FTA2 PF13095.6 ELR13236.1 - 0.0028 17.3 0.0 0.3 10.7 0.0 3.0 3 1 1 4 4 4 1 Kinetochore Sim4 complex subunit FTA2 EGF PF00008.27 ELR13236.1 - 0.0028 17.9 6.0 0.0059 16.9 6.0 1.5 1 0 0 1 1 1 1 EGF-like domain Pkinase_fungal PF17667.1 ELR13236.1 - 0.0031 16.3 0.0 1.5 7.5 0.1 2.2 2 0 0 2 2 2 2 Fungal protein kinase HMD PF03201.16 ELR13236.1 - 0.11 12.7 0.1 0.99 9.7 0.0 2.5 3 0 0 3 3 3 0 H2-forming N5,N10-methylene-tetrahydromethanopterin dehydrogenase EGF_2 PF07974.13 ELR13236.1 - 0.14 12.6 12.7 0.28 11.6 12.7 1.6 1 0 0 1 1 1 0 EGF-like domain Laminin_EGF PF00053.24 ELR13236.1 - 0.44 10.7 8.0 0.88 9.8 8.0 1.4 1 0 0 1 1 1 0 Laminin EGF domain Ras PF00071.22 ELR13237.1 - 4.1e-30 104.5 0.0 7.9e-30 103.6 0.0 1.5 1 1 0 1 1 1 1 Ras family Roc PF08477.13 ELR13237.1 - 0.0027 17.9 0.0 0.014 15.6 0.0 2.0 2 1 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Ser_hydrolase PF06821.13 ELR13237.1 - 0.013 15.3 0.0 0.02 14.8 0.0 1.3 1 0 0 1 1 1 0 Serine hydrolase AAA_16 PF13191.6 ELR13237.1 - 0.022 15.1 0.0 0.036 14.4 0.0 1.6 1 1 0 1 1 1 0 AAA ATPase domain AAA_22 PF13401.6 ELR13237.1 - 0.17 12.2 0.0 0.54 10.5 0.0 1.8 2 0 0 2 2 2 0 AAA domain Hydrolase_4 PF12146.8 ELR13238.1 - 2e-11 43.6 0.0 8.9e-06 25.1 0.0 2.2 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Peptidase_S9 PF00326.21 ELR13238.1 - 1.8e-05 24.3 0.0 0.0018 17.8 0.0 2.2 2 0 0 2 2 2 1 Prolyl oligopeptidase family Abhydrolase_6 PF12697.7 ELR13238.1 - 2.6e-05 24.9 0.4 0.0002 22.0 0.4 2.0 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_2 PF02230.16 ELR13238.1 - 0.0082 16.0 0.0 0.089 12.6 0.0 2.3 3 0 0 3 3 3 1 Phospholipase/Carboxylesterase Abhydrolase_3 PF07859.13 ELR13238.1 - 0.0094 15.8 0.0 0.013 15.4 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_1 PF00561.20 ELR13238.1 - 0.021 14.5 0.1 0.057 13.1 0.0 1.7 2 0 0 2 2 2 0 alpha/beta hydrolase fold DUF789 PF05623.12 ELR13238.1 - 0.057 13.1 0.2 0.086 12.5 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF789) FSH1 PF03959.13 ELR13238.1 - 0.13 11.9 0.0 0.4 10.3 0.0 1.8 1 1 1 2 2 2 0 Serine hydrolase (FSH1) FAM176 PF14851.6 ELR13238.1 - 0.49 10.1 3.8 0.73 9.5 3.8 1.2 1 0 0 1 1 1 0 FAM176 family Metallophos PF00149.28 ELR13239.1 - 5.2e-09 36.9 0.0 1.2e-08 35.7 0.0 1.7 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 ELR13239.1 - 7.4e-07 29.5 0.1 2.1e-05 24.7 0.0 2.3 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase superfamily domain CDC45 PF02724.14 ELR13239.1 - 0.0058 15.0 0.7 0.0082 14.5 0.7 1.1 1 0 0 1 1 1 1 CDC45-like protein DUF836 PF05768.14 ELR13239.1 - 0.15 12.5 0.1 0.3 11.5 0.1 1.4 1 0 0 1 1 1 0 Glutaredoxin-like domain (DUF836) RICTOR_N PF14664.6 ELR13240.1 - 9.1e-68 228.9 0.2 1.4e-67 228.4 0.2 1.3 1 0 0 1 1 1 1 Rapamycin-insensitive companion of mTOR, N-term RICTOR_V PF14668.6 ELR13240.1 - 2.2e-28 98.3 1.1 5.9e-24 84.1 0.1 4.7 4 0 0 4 4 4 2 Rapamycin-insensitive companion of mTOR, domain 5 RasGEF_N_2 PF14663.6 ELR13240.1 - 1.5e-19 70.4 1.0 8.1e-19 68.0 0.1 2.7 2 0 0 2 2 2 1 Rapamycin-insensitive companion of mTOR RasGEF_N domain RICTOR_M PF14666.6 ELR13240.1 - 2.5e-17 62.5 0.5 8.3e-16 57.7 0.2 3.4 3 1 0 3 3 3 1 Rapamycin-insensitive companion of mTOR, middle domain HEAT_EZ PF13513.6 ELR13240.1 - 0.0053 17.2 3.7 5.2 7.7 0.1 4.0 3 0 0 3 3 3 2 HEAT-like repeat PSI PF01437.25 ELR13241.1 - 1.1e-08 35.4 28.0 4.3e-05 24.0 11.8 2.6 2 1 0 2 2 2 2 Plexin repeat PSI_integrin PF17205.3 ELR13241.1 - 0.034 13.9 24.4 0.095 12.5 9.0 2.8 2 1 0 2 2 2 0 Integrin plexin domain GPR15L PF15854.5 ELR13241.1 - 0.062 13.5 1.3 0.062 13.5 1.3 2.3 1 1 1 2 2 2 0 G-protein coupled receptor ligand 15 EphA2_TM PF14575.6 ELR13241.1 - 0.076 13.9 3.7 0.83 10.6 0.7 2.3 2 1 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain Rax2 PF12768.7 ELR13241.1 - 0.16 11.4 0.0 0.16 11.4 0.0 1.7 2 0 0 2 2 2 0 Cortical protein marker for cell polarity Insulin_TMD PF17870.1 ELR13241.1 - 0.2 11.8 0.4 0.2 11.8 0.4 2.0 2 0 0 2 2 2 0 Insulin receptor trans-membrane segment RNA_pol_Rpb4 PF03874.16 ELR13242.1 - 5.8e-12 46.0 1.0 5.8e-12 46.0 1.0 1.6 2 0 0 2 2 2 1 RNA polymerase Rpb4 DOT1 PF08123.13 ELR13244.1 - 7.1e-32 110.6 0.0 6.6e-29 100.9 0.0 2.3 2 0 0 2 2 2 2 Histone methylation protein DOT1 DOT1 PF08123.13 ELR13245.1 - 7.6e-14 51.7 0.3 9.1e-13 48.2 0.3 2.3 1 1 0 1 1 1 1 Histone methylation protein DOT1 Chromo PF00385.24 ELR13245.1 - 1.3e-12 47.4 0.1 5e-12 45.5 0.1 2.1 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain TPR_2 PF07719.17 ELR13246.1 - 3.2e-17 61.2 27.9 0.0032 17.5 0.3 9.8 10 0 0 10 10 10 6 Tetratricopeptide repeat TPR_14 PF13428.6 ELR13246.1 - 8.6e-11 41.7 32.8 0.0045 17.7 0.0 9.3 9 1 1 10 10 10 5 Tetratricopeptide repeat TPR_1 PF00515.28 ELR13246.1 - 3.1e-10 39.4 7.6 0.061 13.2 0.3 7.4 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_8 PF13181.6 ELR13246.1 - 5e-10 38.8 13.8 0.36 11.2 0.1 7.2 8 0 0 8 8 8 4 Tetratricopeptide repeat TPR_16 PF13432.6 ELR13246.1 - 7.5e-10 39.3 35.8 2.1e-05 25.1 0.2 7.6 7 2 3 10 10 10 3 Tetratricopeptide repeat TPR_12 PF13424.6 ELR13246.1 - 3.7e-09 36.8 36.9 0.0012 19.1 1.4 7.7 7 2 0 7 7 7 3 Tetratricopeptide repeat ANAPC3 PF12895.7 ELR13246.1 - 6.5e-07 29.5 8.4 0.18 12.0 0.3 5.8 5 0 0 5 5 5 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_11 PF13414.6 ELR13246.1 - 7.1e-07 28.8 0.2 0.17 11.6 0.1 4.2 3 0 0 3 3 3 2 TPR repeat TPR_6 PF13174.6 ELR13246.1 - 1e-06 28.9 29.9 0.012 16.2 0.0 8.5 10 0 0 10 10 9 4 Tetratricopeptide repeat Wzy_C_2 PF11846.8 ELR13246.1 - 4.8e-06 26.6 3.2 0.00031 20.7 0.2 3.0 3 0 0 3 3 3 1 Virulence factor membrane-bound polymerase, C-terminal TPR_19 PF14559.6 ELR13246.1 - 9.2e-06 26.1 38.6 0.0021 18.6 0.4 8.1 5 2 4 9 9 8 6 Tetratricopeptide repeat TPR_17 PF13431.6 ELR13246.1 - 2e-05 24.7 9.5 0.11 13.0 0.0 6.9 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_7 PF13176.6 ELR13246.1 - 9.5e-05 22.2 10.5 2.4 8.4 0.0 6.6 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_9 PF13371.6 ELR13246.1 - 0.00048 20.2 9.3 3 8.0 0.8 5.0 3 2 2 5 5 5 3 Tetratricopeptide repeat HrpB1_HrpK PF09613.10 ELR13246.1 - 0.026 14.2 2.9 1.5 8.5 0.1 3.6 4 0 0 4 4 4 0 Bacterial type III secretion protein (HrpB1_HrpK) HEAT PF02985.22 ELR13247.1 - 2.9e-08 33.3 15.3 0.0043 17.2 0.6 6.2 6 0 0 6 6 6 3 HEAT repeat HEAT_2 PF13646.6 ELR13247.1 - 3.5e-06 27.3 5.2 0.083 13.3 0.1 5.4 6 0 0 6 6 6 2 HEAT repeats HEAT_EZ PF13513.6 ELR13247.1 - 0.0073 16.8 7.1 0.038 14.5 0.2 4.4 4 0 0 4 4 4 1 HEAT-like repeat CbiJ PF02571.14 ELR13247.1 - 0.015 14.8 0.1 0.033 13.7 0.1 1.5 1 0 0 1 1 1 0 Precorrin-6x reductase CbiJ/CobK IFRD PF05004.13 ELR13247.1 - 0.028 13.5 0.6 0.14 11.2 0.0 2.6 2 0 0 2 2 2 0 Interferon-related developmental regulator (IFRD) RPN2_C PF18004.1 ELR13247.1 - 0.041 13.8 0.7 0.11 12.4 0.7 1.6 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain Arm PF00514.23 ELR13247.1 - 0.15 12.2 6.6 7.5 6.8 0.1 3.7 3 0 0 3 3 3 0 Armadillo/beta-catenin-like repeat XAP5 PF04921.14 ELR13247.1 - 0.26 11.1 2.1 0.55 10.0 2.1 1.5 1 0 0 1 1 1 0 XAP5, circadian clock regulator UME PF08064.13 ELR13247.1 - 8.3 6.4 7.0 7 6.6 0.0 4.4 6 0 0 6 6 6 0 UME (NUC010) domain SBP56 PF05694.11 ELR13248.1 - 2.4e-11 43.2 0.0 1.2e-06 27.7 0.0 2.8 1 1 1 2 2 2 2 56kDa selenium binding protein (SBP56) AraC_binding_2 PF14525.6 ELR13248.1 - 0.02 14.6 0.4 1.1 8.9 0.1 2.5 2 0 0 2 2 2 0 AraC-binding-like domain DUF1455 PF07306.11 ELR13248.1 - 0.041 13.8 0.4 0.095 12.7 0.4 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1455) YbjN PF10722.9 ELR13248.1 - 0.13 12.3 0.0 0.32 11.0 0.0 1.6 1 0 0 1 1 1 0 Putative bacterial sensory transduction regulator Rif1_N PF12231.8 ELR13249.1 - 9.6e-28 97.2 1.7 1.5e-26 93.3 1.7 2.3 1 1 0 1 1 1 1 Rap1-interacting factor 1 N terminal Acetyltransf_1 PF00583.25 ELR13250.1 - 2.5e-11 43.9 0.0 3.9e-11 43.2 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 ELR13250.1 - 5.1e-11 42.6 0.0 8.8e-11 41.8 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 ELR13250.1 - 2.8e-10 40.5 0.0 6.1e-10 39.4 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 ELR13250.1 - 0.00038 20.5 0.0 0.00089 19.3 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 ELR13250.1 - 0.00082 19.3 0.0 0.0016 18.4 0.0 1.5 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_CG PF14542.6 ELR13250.1 - 0.0016 18.5 0.0 0.0039 17.3 0.0 1.5 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase EF-hand_1 PF00036.32 ELR13251.1 - 4.4e-20 69.7 1.3 6.2e-05 22.3 0.1 4.5 5 0 0 5 5 5 4 EF hand EF-hand_5 PF13202.6 ELR13251.1 - 9.2e-20 69.2 0.6 7e-05 22.1 0.0 4.4 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.6 ELR13251.1 - 8.2e-19 65.9 0.7 0.00063 19.5 0.0 4.5 4 0 0 4 4 4 4 EF-hand domain EF-hand_7 PF13499.6 ELR13251.1 - 9.3e-15 54.8 0.6 3.8e-07 30.5 0.1 3.4 2 2 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 ELR13251.1 - 2e-09 37.1 0.3 0.018 14.9 0.0 4.2 4 0 0 4 4 4 2 EF-hand domain pair Dockerin_1 PF00404.18 ELR13251.1 - 0.01 16.0 0.5 0.65 10.2 0.0 3.0 3 0 0 3 3 3 0 Dockerin type I domain EF-hand_4 PF12763.7 ELR13251.1 - 0.019 14.9 0.0 0.06 13.3 0.0 1.8 1 1 1 2 2 2 0 Cytoskeletal-regulatory complex EF hand EF-hand_10 PF14788.6 ELR13251.1 - 0.16 11.9 0.0 3.8 7.5 0.0 2.5 2 0 0 2 2 2 0 EF hand VCBS PF13517.6 ELR13251.1 - 0.6 10.7 4.9 6.4 7.5 3.1 3.0 2 1 0 2 2 2 0 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella TFIIA PF03153.13 ELR13251.1 - 0.81 9.6 22.7 1 9.3 22.7 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF1648 PF07853.11 ELR13252.1 - 6.7e-11 41.7 0.1 6.7e-11 41.7 0.1 2.2 2 1 1 3 3 3 1 Protein of unknown function (DUF1648) Phage_holin_3_6 PF07332.11 ELR13252.1 - 0.43 10.6 5.2 0.9 9.6 1.3 2.2 2 0 0 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III DUF4307 PF14155.6 ELR13252.1 - 5.5 6.9 5.2 4.6 7.1 0.0 2.4 3 0 0 3 3 3 0 Domain of unknown function (DUF4307) ADP_ribosyl_GH PF03747.14 ELR13253.1 - 2.6e-43 148.8 1.6 5e-43 147.9 1.6 1.4 1 1 0 1 1 1 1 ADP-ribosylglycohydrolase zf-RanBP PF00641.18 ELR13253.1 - 0.0015 17.8 3.3 0.0028 16.9 3.3 1.5 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others Siva PF05458.12 ELR13254.1 - 0.0077 15.9 7.8 0.0077 15.9 7.8 2.8 2 1 1 3 3 3 1 Cd27 binding protein (Siva) HA PF03457.14 ELR13255.1 - 0.0064 16.8 0.3 0.016 15.5 0.3 1.7 1 0 0 1 1 1 1 Helicase associated domain RRN3 PF05327.11 ELR13255.1 - 7 5.1 12.2 0.61 8.6 5.7 1.9 2 0 0 2 2 2 0 RNA polymerase I specific transcription initiation factor RRN3 Aa_trans PF01490.18 ELR13256.1 - 7.4e-44 150.1 0.0 1.1e-30 106.7 0.0 2.5 1 1 1 2 2 2 2 Transmembrane amino acid transporter protein Snf7 PF03357.21 ELR13256.1 - 4.3 6.9 6.2 6.6 6.3 6.2 1.2 1 0 0 1 1 1 0 Snf7 DRY_EERY PF09750.9 ELR13258.1 - 0.32 11.3 4.5 1.1 9.6 4.5 1.9 1 1 0 1 1 1 0 Alternative splicing regulator ABC2_membrane_3 PF12698.7 ELR13259.1 - 1.6 7.7 10.4 2.8 7.0 10.4 1.3 1 0 0 1 1 1 0 ABC-2 family transporter protein Par3_HAL_N_term PF12053.8 ELR13260.1 - 1.5e-11 44.3 0.1 3.7e-11 43.1 0.1 1.6 1 0 0 1 1 1 1 N-terminal of Par3 and HAL proteins DUF2313 PF10076.9 ELR13261.1 - 0.029 14.2 0.0 0.05 13.5 0.0 1.4 1 0 0 1 1 1 0 Uncharacterised protein conserved in bacteria (DUF2313) FG-GAP PF01839.23 ELR13262.1 - 4.1e-31 106.7 35.3 8.7e-07 29.0 0.7 6.7 6 0 0 6 6 6 5 FG-GAP repeat VCBS PF13517.6 ELR13262.1 - 3.5e-23 82.0 9.1 3.1e-08 34.1 1.4 4.6 3 1 1 4 4 4 4 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella TcdB_toxin_midN PF12256.8 ELR13262.1 - 6e-13 48.5 3.0 0.034 13.5 0.0 5.2 5 0 0 5 5 5 5 Insecticide toxin TcdB middle/N-terminal region Zn_dep_PLPC PF00882.18 ELR13262.1 - 2.2e-12 47.3 0.4 3.5e-12 46.7 0.4 1.3 1 0 0 1 1 1 1 Zinc dependent phospholipase C PliI PF16743.5 ELR13262.1 - 0.083 12.6 0.0 19 5.1 0.0 3.5 4 0 0 4 4 4 0 Periplasmic lysozyme inhibitor of I-type lysozyme STAT_bind PF02864.15 ELR13263.1 - 0.084 13.4 2.2 0.13 12.8 2.2 1.3 1 0 0 1 1 1 0 STAT protein, DNA binding domain CDC45 PF02724.14 ELR13263.1 - 0.32 9.2 12.6 0.35 9.1 12.6 1.1 1 0 0 1 1 1 0 CDC45-like protein Zip PF02535.22 ELR13263.1 - 0.47 9.6 3.4 0.49 9.6 3.4 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Neur_chan_memb PF02932.16 ELR13263.1 - 0.54 10.3 6.6 0.6 10.1 6.6 1.0 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Sporozoite_P67 PF05642.11 ELR13263.1 - 0.76 7.8 4.9 0.85 7.6 4.9 1.0 1 0 0 1 1 1 0 Sporozoite P67 surface antigen FAM76 PF16046.5 ELR13263.1 - 1.1 8.5 9.5 1.2 8.4 9.5 1.2 1 0 0 1 1 1 0 FAM76 protein Rrn6 PF10214.9 ELR13263.1 - 1.6 7.1 14.7 1.7 7.1 14.7 1.0 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor Apt1 PF10351.9 ELR13263.1 - 5.1 5.8 13.2 5.3 5.8 13.2 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain NPR3 PF03666.13 ELR13263.1 - 8.9 5.0 12.3 10 4.8 12.3 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Presenilin PF01080.17 ELR13263.1 - 9.2 4.9 11.1 9.9 4.8 11.1 1.1 1 0 0 1 1 1 0 Presenilin CBS PF00571.28 ELR13265.1 - 2.4e-27 95.2 0.5 1.7e-08 34.8 0.0 4.3 4 0 0 4 4 4 4 CBS domain Pkinase_Tyr PF07714.17 ELR13266.1 - 7.3e-16 58.2 0.0 1.9e-15 56.9 0.0 1.7 1 0 0 1 1 1 1 Protein tyrosine kinase PLDc_2 PF13091.6 ELR13266.1 - 3.6e-14 52.8 0.0 1.3e-08 34.9 0.0 2.5 2 0 0 2 2 2 2 PLD-like domain Pkinase PF00069.25 ELR13266.1 - 6e-09 35.6 0.0 1.7e-08 34.1 0.0 1.7 1 1 0 1 1 1 1 Protein kinase domain PLDc PF00614.22 ELR13266.1 - 8.6e-06 25.7 8.2 0.00052 20.1 0.1 3.3 3 1 0 3 3 3 2 Phospholipase D Active site motif MITF_TFEB_C_3_N PF15951.5 ELR13267.1 - 0.02 15.5 0.2 0.034 14.8 0.1 1.4 1 1 0 1 1 1 0 MITF/TFEB/TFEC/TFE3 N-terminus DUF4611 PF15387.6 ELR13267.1 - 5.7 7.2 9.3 0.93 9.7 3.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4611) Dsh_C PF12316.8 ELR13268.1 - 0.0084 16.5 8.1 0.0084 16.5 8.1 1.7 2 0 0 2 2 2 1 Segment polarity protein dishevelled (Dsh) C terminal DUF4551 PF15087.6 ELR13268.1 - 6 5.6 12.7 6.9 5.4 12.7 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) CPSF100_C PF13299.6 ELR13268.1 - 6.4 6.9 17.7 0.68 10.1 6.2 2.2 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal DUF4746 PF15928.5 ELR13268.1 - 6.8 6.0 16.6 6.4 6.1 1.7 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4746) 2_5_RNA_ligase2 PF13563.6 ELR13269.1 - 1.2e-32 113.0 0.4 2e-32 112.2 0.1 1.5 2 0 0 2 2 2 1 2'-5' RNA ligase superfamily RRM_1 PF00076.22 ELR13269.1 - 3.2e-07 30.1 0.1 1.3e-06 28.1 0.1 2.0 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) AKAP7_NLS PF10469.9 ELR13269.1 - 0.00044 20.2 0.0 0.00071 19.5 0.0 1.2 1 0 0 1 1 1 1 AKAP7 2'5' RNA ligase-like domain LigT_PEase PF02834.16 ELR13269.1 - 0.0019 18.4 0.3 0.47 10.7 0.0 3.0 3 0 0 3 3 3 1 LigT like Phosphoesterase HalOD2 PF18547.1 ELR13270.1 - 0.057 13.3 3.7 0.093 12.7 1.2 2.7 2 1 0 2 2 2 0 Halobacterial output domain 2 BRCT_2 PF16589.5 ELR13270.1 - 0.11 12.9 0.0 0.22 12.0 0.0 1.4 1 0 0 1 1 1 0 BRCT domain, a BRCA1 C-terminus domain BRCT PF00533.26 ELR13270.1 - 0.13 12.6 0.0 0.22 11.9 0.0 1.3 1 0 0 1 1 1 0 BRCA1 C Terminus (BRCT) domain zinc_ribbon_10 PF10058.9 ELR13270.1 - 0.69 9.7 11.1 0.68 9.7 0.3 3.9 4 0 0 4 4 4 0 Predicted integral membrane zinc-ribbon metal-binding protein zf-C4pol PF14260.6 ELR13270.1 - 8.9 6.9 12.9 4.6e+02 1.4 0.1 3.4 1 1 1 2 2 2 0 C4-type zinc-finger of DNA polymerase delta GMC_oxred_N PF00732.19 ELR13271.1 - 4.1e-39 134.7 0.0 3.9e-37 128.2 0.0 2.1 1 1 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 ELR13272.1 - 4.2e-25 89.0 0.1 9.8e-25 87.8 0.1 1.5 1 1 0 1 1 1 1 GMC oxidoreductase Mpv17_PMP22 PF04117.12 ELR13274.1 - 4e-13 49.4 6.5 8.1e-13 48.4 6.5 1.5 1 0 0 1 1 1 1 Mpv17 / PMP22 family His_Phos_1 PF00300.22 ELR13276.1 - 4.6e-09 36.3 0.0 1.1e-08 35.0 0.0 1.6 2 0 0 2 2 2 1 Histidine phosphatase superfamily (branch 1) LCM PF04072.14 ELR13277.1 - 2.4e-16 60.2 0.0 4.4e-16 59.4 0.0 1.4 1 0 0 1 1 1 1 Leucine carboxyl methyltransferase Ion_trans PF00520.31 ELR13281.1 - 2.9e-09 36.5 6.9 3.6e-09 36.2 6.9 1.3 1 0 0 1 1 1 1 Ion transport protein Caroten_synth PF04240.12 ELR13282.1 - 8.2e-09 35.6 1.4 1.1e-08 35.3 1.1 1.5 1 1 0 1 1 1 1 Carotenoid biosynthesis protein Homeodomain PF00046.29 ELR13283.1 - 9e-19 67.1 0.5 9e-19 67.1 0.5 2.0 2 0 0 2 2 2 1 Homeodomain Homeobox_KN PF05920.11 ELR13283.1 - 0.0007 19.4 0.0 0.0007 19.4 0.0 2.5 2 1 1 3 3 3 1 Homeobox KN domain Homez PF11569.8 ELR13283.1 - 0.19 11.2 0.0 0.19 11.2 0.0 2.8 3 0 0 3 3 3 0 Homeodomain leucine-zipper encoding, Homez BSP_II PF05432.11 ELR13283.1 - 0.28 10.9 5.3 0.047 13.4 1.5 1.5 2 0 0 2 2 2 0 Bone sialoprotein II (BSP-II) TFIIE-A_C PF11521.8 ELR13283.1 - 4.7 7.6 9.0 0.43 10.9 3.8 2.0 2 0 0 2 2 2 0 C-terminal general transcription factor TFIIE alpha Solute_trans_a PF03619.16 ELR13284.1 - 2.8e-88 295.9 23.6 4.5e-40 137.9 3.5 3.1 1 1 2 3 3 3 3 Organic solute transporter Ostalpha PH PF00169.29 ELR13284.1 - 0.00039 20.9 0.2 0.00071 20.1 0.2 1.4 1 0 0 1 1 1 1 PH domain PH PF00169.29 ELR13285.1 - 0.00041 20.8 0.0 0.00055 20.4 0.0 1.3 1 0 0 1 1 1 1 PH domain Pkinase_Tyr PF07714.17 ELR13286.1 - 2.3e-85 286.0 0.0 3e-85 285.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ELR13286.1 - 9.8e-49 166.1 0.0 1.5e-48 165.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain SAM_1 PF00536.30 ELR13286.1 - 7.6e-11 42.3 0.2 1.7e-10 41.1 0.2 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 ELR13286.1 - 2.1e-09 37.3 0.1 4.5e-09 36.3 0.1 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Kdo PF06293.14 ELR13286.1 - 7.3e-05 22.2 0.3 7.3e-05 22.2 0.3 1.7 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Ras PF00071.22 ELR13286.1 - 0.00028 20.5 0.0 0.00077 19.1 0.0 1.7 1 1 0 1 1 1 1 Ras family Kinase-like PF14531.6 ELR13286.1 - 0.018 14.3 0.0 0.03 13.7 0.0 1.3 1 0 0 1 1 1 0 Kinase-like Pkinase_fungal PF17667.1 ELR13286.1 - 0.055 12.2 0.2 0.089 11.6 0.2 1.2 1 0 0 1 1 1 0 Fungal protein kinase Haspin_kinase PF12330.8 ELR13286.1 - 0.067 12.1 0.4 0.21 10.5 0.1 1.8 2 0 0 2 2 2 0 Haspin like kinase domain WD40 PF00400.32 ELR13287.1 - 1.4e-07 32.1 7.1 0.0071 17.2 0.1 4.5 4 0 0 4 4 4 2 WD domain, G-beta repeat PQQ_3 PF13570.6 ELR13287.1 - 0.00016 22.1 0.0 10 6.8 0.0 4.3 3 2 1 4 4 4 2 PQQ-like domain WD40_like PF17005.5 ELR13287.1 - 0.0028 17.0 0.0 0.004 16.5 0.0 1.4 1 0 0 1 1 1 1 WD40-like domain Reg_prop PF07494.11 ELR13287.1 - 0.092 13.0 0.5 6.5 7.3 0.1 3.2 3 0 0 3 3 3 0 Two component regulator propeller NUDE_C PF04880.13 ELR13289.1 - 2.5e-08 34.6 10.1 2.5e-08 34.6 10.1 3.1 2 2 2 4 4 4 1 NUDE protein, C-terminal conserved region UPF0242 PF06785.11 ELR13289.1 - 0.00015 21.9 12.3 0.00015 21.9 12.3 2.2 1 1 1 2 2 2 1 Uncharacterised protein family (UPF0242) N-terminus Spc7 PF08317.11 ELR13289.1 - 0.012 14.5 33.9 0.12 11.2 16.4 2.2 1 1 1 2 2 2 0 Spc7 kinetochore protein DUF5082 PF16888.5 ELR13289.1 - 0.085 13.1 11.1 0.48 10.7 3.7 2.7 2 1 0 2 2 2 0 Domain of unknown function (DUF5082) DUF3584 PF12128.8 ELR13289.1 - 0.28 8.7 32.4 1 6.8 9.8 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF3584) DUF1664 PF07889.12 ELR13289.1 - 0.54 10.3 9.5 1.1 9.3 2.9 3.1 2 2 0 2 2 2 0 Protein of unknown function (DUF1664) SATase_N PF06426.14 ELR13289.1 - 0.7 10.3 3.8 5.9 7.3 0.4 2.4 2 0 0 2 2 2 0 Serine acetyltransferase, N-terminal Filament PF00038.21 ELR13289.1 - 1.5 8.3 30.7 0.1 12.1 9.7 3.0 1 1 2 3 3 3 0 Intermediate filament protein DUF3683 PF12447.8 ELR13289.1 - 2.3 8.4 6.5 3.2 7.9 0.6 2.9 2 1 0 2 2 2 0 Protein of unknown function (DUF3683) F-box-like PF12937.7 ELR13290.1 - 7.5e-12 45.0 1.0 1.6e-11 43.9 1.0 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ELR13290.1 - 1.3e-09 37.7 0.0 2.1e-09 37.0 0.0 1.3 1 0 0 1 1 1 1 F-box domain CENP-B_dimeris PF09026.10 ELR13290.1 - 0.00012 22.4 27.2 0.0021 18.4 8.3 3.4 3 0 0 3 3 3 3 Centromere protein B dimerisation domain FAM176 PF14851.6 ELR13290.1 - 0.61 9.7 22.1 0.16 11.6 0.5 3.2 3 0 0 3 3 3 0 FAM176 family Presenilin PF01080.17 ELR13290.1 - 6.3 5.5 11.2 1 8.1 3.3 2.1 2 0 0 2 2 2 0 Presenilin Acyltransf_C PF16076.5 ELR13291.1 - 0.016 15.3 0.3 0.037 14.1 0.3 1.6 1 0 0 1 1 1 0 Acyltransferase C-terminus Acyltransferase PF01553.21 ELR13291.1 - 0.026 14.1 0.0 0.062 12.9 0.0 1.6 1 0 0 1 1 1 0 Acyltransferase K_channel_TID PF07941.11 ELR13291.1 - 0.03 14.8 3.7 0.03 14.8 3.7 2.5 3 0 0 3 3 3 0 Potassium channel Kv1.4 tandem inactivation domain BTB PF00651.31 ELR13292.1 - 2.6e-18 66.2 0.0 8.6e-17 61.4 0.0 2.3 1 1 1 2 2 2 1 BTB/POZ domain BACK PF07707.15 ELR13292.1 - 1.8e-14 53.7 0.1 4.1e-14 52.5 0.1 1.6 1 0 0 1 1 1 1 BTB And C-terminal Kelch SPRY PF00622.28 ELR13292.1 - 3.4e-11 43.3 0.1 5.8e-11 42.6 0.1 1.3 1 0 0 1 1 1 1 SPRY domain GDPD PF03009.17 ELR13293.1 - 8.1e-35 120.8 0.0 7.3e-26 91.4 0.0 2.2 1 1 1 2 2 2 2 Glycerophosphoryl diester phosphodiesterase family CBM_20 PF00686.19 ELR13293.1 - 3e-13 49.5 0.0 1.4e-12 47.4 0.0 2.0 2 0 0 2 2 2 1 Starch binding domain Sterol_MT_C PF08498.10 ELR13294.1 - 1.2e-20 73.6 0.7 6.5e-20 71.2 0.2 2.1 2 0 0 2 2 2 1 Sterol methyltransferase C-terminal Methyltransf_11 PF08241.12 ELR13294.1 - 3.4e-19 69.3 0.0 1.2e-18 67.5 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 ELR13294.1 - 7.3e-17 61.9 0.1 3e-16 59.9 0.0 2.0 3 0 0 3 3 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 ELR13294.1 - 5.4e-15 55.5 0.0 7.7e-15 55.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 ELR13294.1 - 1.2e-10 41.2 0.0 1.7e-10 40.6 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_23 PF13489.6 ELR13294.1 - 1.8e-10 40.9 0.0 3.5e-10 40.0 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 ELR13294.1 - 8.4e-09 35.1 0.0 1.9e-08 34.0 0.0 1.5 2 0 0 2 2 2 1 ubiE/COQ5 methyltransferase family Methyltransf_12 PF08242.12 ELR13294.1 - 3.1e-08 34.3 0.0 3e-07 31.1 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain MetW PF07021.12 ELR13294.1 - 0.0022 17.6 0.0 0.0033 17.1 0.0 1.2 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW PCMT PF01135.19 ELR13294.1 - 0.0025 17.6 0.0 0.0065 16.2 0.0 1.7 1 1 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) MTS PF05175.14 ELR13294.1 - 0.0051 16.4 0.0 0.013 15.1 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase small domain Methyltransf_32 PF13679.6 ELR13294.1 - 0.025 14.6 0.0 0.041 13.9 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain DUF1912 PF08930.10 ELR13294.1 - 0.15 12.2 1.1 0.34 11.1 1.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1912) ICAT PF06384.11 ELR13295.1 - 2.1e-28 98.4 6.4 2.2e-28 98.3 0.9 2.2 2 0 0 2 2 2 1 Beta-catenin-interacting protein ICAT Dynamin_M PF01031.20 ELR13295.1 - 0.015 14.5 0.9 0.026 13.8 0.3 1.5 2 0 0 2 2 2 0 Dynamin central region CAMP_factor PF07373.11 ELR13295.1 - 0.029 14.0 0.3 0.047 13.3 0.3 1.3 1 0 0 1 1 1 0 CAMP factor (Cfa) OmpH PF03938.14 ELR13295.1 - 0.077 13.3 6.9 0.044 14.1 4.6 1.6 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) FAP206 PF12018.8 ELR13295.1 - 0.11 12.0 2.7 0.22 11.0 2.5 1.6 1 1 0 1 1 1 0 Domain of unknown function FlxA PF14282.6 ELR13295.1 - 0.2 11.7 6.3 0.06 13.3 3.4 1.7 2 0 0 2 2 2 0 FlxA-like protein Syntaxin-6_N PF09177.11 ELR13295.1 - 0.58 10.7 3.9 0.75 10.4 1.8 2.1 2 0 0 2 2 2 0 Syntaxin 6, N-terminal SCP2 PF02036.17 ELR13296.1 - 1.3e-53 179.7 2.7 8.1e-28 96.9 0.2 2.1 2 0 0 2 2 2 2 SCP-2 sterol transfer family Alkyl_sulf_C PF14864.6 ELR13296.1 - 2.1e-13 50.7 0.1 9.4e-06 25.9 0.0 2.2 2 0 0 2 2 2 2 Alkyl sulfatase C-terminal pPIWI_RE_REase PF18154.1 ELR13296.1 - 0.034 14.1 0.1 1.5 8.8 0.0 2.6 2 1 1 3 3 3 0 REase associating with pPIWI_RE UvrD_C PF13361.6 ELR13297.1 - 0.0085 15.5 0.0 0.0085 15.5 0.0 1.0 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain SK_channel PF03530.14 ELR13298.1 - 0.001 19.0 0.0 0.0016 18.4 0.0 1.3 1 0 0 1 1 1 1 Calcium-activated SK potassium channel DUF5408 PF17402.2 ELR13298.1 - 0.021 14.7 1.1 0.038 13.9 0.1 1.8 2 0 0 2 2 2 0 Family of unknown function (DUF5408) Vut_1 PF02592.15 ELR13298.1 - 0.051 13.9 0.1 0.065 13.6 0.1 1.3 1 0 0 1 1 1 0 Putative vitamin uptake transporter RFX_DNA_binding PF02257.15 ELR13299.1 - 9.9e-14 51.7 0.3 7.7e-13 48.9 0.0 2.3 2 0 0 2 2 2 1 RFX DNA-binding domain Macoilin PF09726.9 ELR13299.1 - 1.3 7.5 5.2 1.5 7.3 5.2 1.2 1 0 0 1 1 1 0 Macoilin family Rap_GAP PF02145.15 ELR13300.1 - 1.4e-52 178.0 0.0 1.7e-52 177.7 0.0 1.1 1 0 0 1 1 1 1 Rap/ran-GAP UPF0242 PF06785.11 ELR13301.1 - 0.0012 19.0 0.1 0.0022 18.1 0.1 1.4 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0242) N-terminus Atg14 PF10186.9 ELR13301.1 - 0.044 12.9 0.3 0.094 11.8 0.3 1.4 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Sipho_Gp157 PF05565.11 ELR13301.1 - 0.054 13.5 0.8 0.12 12.4 0.8 1.4 1 0 0 1 1 1 0 Siphovirus Gp157 NAT PF04768.13 ELR13301.1 - 0.13 11.9 0.1 0.23 11.1 0.1 1.3 1 0 0 1 1 1 0 NAT, N-acetyltransferase, of N-acetylglutamate synthase ACOX PF01756.19 ELR13302.1 - 4.3e-21 75.3 0.0 7e-21 74.6 0.0 1.3 1 0 0 1 1 1 1 Acyl-CoA oxidase Acyl-CoA_dh_M PF02770.19 ELR13302.1 - 1.5e-17 63.6 0.0 2.6e-17 62.8 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_1 PF00441.24 ELR13302.1 - 0.00018 21.7 0.1 0.0016 18.6 0.1 2.2 1 1 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain RasGEF PF00617.19 ELR13303.1 - 6.1e-38 130.8 0.0 9.5e-38 130.2 0.0 1.3 1 0 0 1 1 1 1 RasGEF domain DDHD PF02862.17 ELR13303.1 - 0.16 12.1 5.2 0.65 10.1 0.4 3.0 4 0 0 4 4 4 0 DDHD domain DUF4776 PF16003.5 ELR13303.1 - 0.32 9.9 4.9 0.74 8.7 4.9 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4776) Coilin_N PF15862.5 ELR13303.1 - 7.7 6.3 8.7 23 4.8 8.7 1.8 1 0 0 1 1 1 0 Coilin N-terminus WD40 PF00400.32 ELR13304.1 - 5.3e-27 93.5 7.9 9.8e-07 29.4 0.4 6.4 6 0 0 6 6 6 5 WD domain, G-beta repeat PQQ_3 PF13570.6 ELR13304.1 - 2.1e-08 34.4 0.4 0.32 11.5 0.1 5.9 6 0 0 6 6 6 2 PQQ-like domain Nup160 PF11715.8 ELR13304.1 - 7.7e-06 24.8 2.5 0.57 8.8 0.0 4.6 2 2 3 6 6 6 3 Nucleoporin Nup120/160 WD40_like PF17005.5 ELR13304.1 - 1.6e-05 24.4 0.3 0.14 11.4 0.0 3.5 2 2 1 3 3 3 2 WD40-like domain PQQ_2 PF13360.6 ELR13304.1 - 0.0047 16.5 0.2 0.17 11.5 0.1 3.0 2 2 0 2 2 2 1 PQQ-like domain PQQ PF01011.21 ELR13304.1 - 0.011 15.6 1.5 0.17 11.9 0.0 3.6 5 0 0 5 5 5 0 PQQ enzyme repeat Pox_I3 PF04661.12 ELR13304.1 - 0.083 12.0 0.0 0.15 11.2 0.0 1.3 1 0 0 1 1 1 0 Poxvirus I3 ssDNA-binding protein WD40_4 PF16300.5 ELR13305.1 - 2.3e-18 65.8 0.2 3.9e-18 65.1 0.2 1.4 1 0 0 1 1 1 1 Type of WD40 repeat DUF1899 PF08953.11 ELR13305.1 - 1e-16 60.5 0.0 1.6e-16 59.9 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1899) WD40 PF00400.32 ELR13305.1 - 1.3e-12 48.0 0.3 0.00078 20.2 0.0 4.7 4 0 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ELR13305.1 - 1.1e-07 32.0 0.0 3.7e-05 23.9 0.0 3.0 1 1 2 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain WD40_3 PF15911.5 ELR13305.1 - 0.17 11.9 0.0 7.9 6.6 0.0 3.1 3 0 0 3 3 3 0 WD domain, G-beta repeat zf-CCHC_3 PF13917.6 ELR13306.1 - 6.1e-16 58.1 0.6 1.4e-15 56.9 0.6 1.7 1 0 0 1 1 1 1 Zinc knuckle Sec10 PF07393.11 ELR13306.1 - 2.1 6.6 13.8 2.5 6.4 13.8 1.2 1 0 0 1 1 1 0 Exocyst complex component Sec10 TAF8_C PF10406.9 ELR13307.1 - 1.2e-13 51.4 0.6 1.2e-13 51.4 0.6 2.4 2 0 0 2 2 2 1 Transcription factor TFIID complex subunit 8 C-term Bromo_TP PF07524.13 ELR13307.1 - 7.8e-06 25.8 0.0 1.5e-05 24.9 0.0 1.4 1 0 0 1 1 1 1 Bromodomain associated Nop25 PF09805.9 ELR13307.1 - 0.069 13.6 3.0 8.6 6.8 0.8 2.2 2 0 0 2 2 2 0 Nucleolar protein 12 (25kDa) Phosducin PF02114.16 ELR13307.1 - 0.071 12.0 0.2 0.1 11.5 0.2 1.1 1 0 0 1 1 1 0 Phosducin RhoGEF PF00621.20 ELR13308.1 - 2.9e-16 60.2 0.0 5e-16 59.5 0.0 1.4 1 0 0 1 1 1 1 RhoGEF domain MMM1 PF10296.9 ELR13308.1 - 4.6e-09 35.8 0.0 0.00065 18.9 0.0 2.2 2 0 0 2 2 2 2 Maintenance of mitochondrial morphology protein 1 PH PF00169.29 ELR13308.1 - 0.0019 18.7 0.0 0.47 11.0 0.0 2.5 2 0 0 2 2 2 1 PH domain Nup96 PF12110.8 ELR13308.1 - 0.031 13.4 0.0 0.072 12.2 0.0 1.5 1 0 0 1 1 1 0 Nuclear protein 96 DUF4667 PF15700.5 ELR13308.1 - 0.14 12.2 1.1 0.3 11.2 1.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4667) DUF4611 PF15387.6 ELR13308.1 - 0.25 11.6 1.0 1.1 9.5 0.4 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4611) UDG PF03167.19 ELR13309.1 - 9.2e-06 25.7 0.0 1.5e-05 25.0 0.0 1.3 1 0 0 1 1 1 1 Uracil DNA glycosylase superfamily BLI1 PF17324.2 ELR13309.1 - 0.16 12.6 0.7 0.24 12.1 0.7 1.2 1 0 0 1 1 1 0 BLOC-1 interactor 1 UDG PF03167.19 ELR13310.1 - 4.5e-10 39.7 0.0 5.3e-10 39.5 0.0 1.0 1 0 0 1 1 1 1 Uracil DNA glycosylase superfamily TLD PF07534.16 ELR13311.1 - 9.7e-14 51.8 2.0 2.3e-05 24.7 1.5 3.0 1 1 1 2 2 2 2 TLD PBP_like_2 PF12849.7 ELR13313.1 - 2.7e-09 37.1 0.0 3e-09 37.0 0.0 1.1 1 0 0 1 1 1 1 PBP superfamily domain CBS PF00571.28 ELR13314.1 - 2e-17 63.3 2.8 3.7e-09 36.9 0.1 3.2 3 0 0 3 3 3 3 CBS domain Peptidase_M28 PF04389.17 ELR13315.1 - 4.9e-45 153.7 0.0 6e-45 153.4 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M28 zf-C2H2_jaz PF12171.8 ELR13316.1 - 1.6e-05 25.0 0.0 2.7e-05 24.3 0.0 1.4 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 ELR13316.1 - 3.7e-05 24.0 0.0 6.2e-05 23.2 0.0 1.4 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.7 ELR13316.1 - 0.08 13.3 0.1 0.19 12.1 0.1 1.6 1 0 0 1 1 1 0 C2H2 type zinc-finger (2 copies) TFIIA PF03153.13 ELR13316.1 - 0.41 10.6 32.8 0.55 10.2 32.5 1.4 1 1 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit NAD_binding_2 PF03446.15 ELR13318.1 - 1.3e-35 122.9 0.2 2.6e-35 121.9 0.2 1.4 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.6 ELR13318.1 - 1.5e-13 51.0 0.2 3.1e-13 50.0 0.2 1.5 1 0 0 1 1 1 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase F420_oxidored PF03807.17 ELR13318.1 - 1.6e-09 38.2 0.1 4.4e-09 36.8 0.1 1.8 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent Shikimate_DH PF01488.20 ELR13318.1 - 8.4e-08 32.4 0.0 6.2e-07 29.6 0.0 2.3 3 0 0 3 3 3 1 Shikimate / quinate 5-dehydrogenase ApbA PF02558.16 ELR13318.1 - 1.3e-05 24.9 0.1 3.1e-05 23.6 0.0 1.7 2 0 0 2 2 2 1 Ketopantoate reductase PanE/ApbA IlvN PF07991.12 ELR13318.1 - 4.2e-05 23.2 0.0 8.3e-05 22.2 0.0 1.4 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain 2-Hacid_dh_C PF02826.19 ELR13318.1 - 7.8e-05 22.1 0.0 0.00016 21.1 0.0 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_Gly3P_dh_N PF01210.23 ELR13318.1 - 0.002 18.2 0.2 0.0057 16.6 0.1 1.8 1 1 1 2 2 2 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus 3HCDH_N PF02737.18 ELR13318.1 - 0.0028 17.6 0.8 0.0062 16.4 0.3 1.8 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain adh_short PF00106.25 ELR13318.1 - 0.017 14.6 0.0 4 6.9 0.0 2.4 2 1 0 2 2 2 0 short chain dehydrogenase Sacchrp_dh_NADP PF03435.18 ELR13318.1 - 0.041 14.2 0.1 0.12 12.7 0.0 1.9 2 1 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain DpaA_N PF16924.5 ELR13318.1 - 0.057 13.5 0.0 0.13 12.4 0.0 1.5 1 0 0 1 1 1 0 Dipicolinate synthase subunit A N-terminal domain Aa_trans PF01490.18 ELR13319.1 - 4e-40 137.8 23.1 2.8e-39 135.0 23.1 1.9 1 1 0 1 1 1 1 Transmembrane amino acid transporter protein Cyt-b5 PF00173.28 ELR13319.1 - 9.6e-20 70.5 0.0 1.6e-19 69.8 0.0 1.4 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain RseC_MucC PF04246.12 ELR13319.1 - 7.2 6.6 9.8 6 6.8 3.3 2.9 1 1 1 2 2 2 0 Positive regulator of sigma(E), RseC/MucC WD40 PF00400.32 ELR13321.1 - 4.3e-05 24.2 7.3 0.017 15.9 0.0 4.9 5 0 0 5 5 5 2 WD domain, G-beta repeat PQQ_3 PF13570.6 ELR13321.1 - 0.004 17.6 0.2 13 6.4 0.0 4.2 4 0 0 4 4 4 1 PQQ-like domain Nbas_N PF15492.6 ELR13321.1 - 0.13 11.5 0.0 0.22 10.8 0.0 1.3 1 0 0 1 1 1 0 Neuroblastoma-amplified sequence, N terminal PIRT PF15099.6 ELR13322.1 - 0.26 10.9 6.7 1.1 8.9 6.1 2.2 2 0 0 2 2 2 0 Phosphoinositide-interacting protein family RhoGEF PF00621.20 ELR13323.1 - 6.7e-26 91.6 0.1 1.3e-25 90.7 0.0 1.6 2 0 0 2 2 2 1 RhoGEF domain U3_snoRNA_assoc PF08297.11 ELR13323.1 - 1 10.1 18.2 0.069 13.9 9.6 3.4 3 0 0 3 3 3 0 U3 snoRNA associated Hamartin PF04388.12 ELR13323.1 - 10 4.7 25.7 0.13 10.9 8.3 2.2 2 0 0 2 2 2 0 Hamartin protein Hemerythrin PF01814.23 ELR13324.1 - 2.7e-14 53.9 7.8 4.2e-14 53.3 7.8 1.3 1 0 0 1 1 1 1 Hemerythrin HHE cation binding domain BAR_3 PF16746.5 ELR13324.1 - 0.033 13.9 0.8 0.041 13.6 0.8 1.1 1 0 0 1 1 1 0 BAR domain of APPL family Rep_3 PF01051.21 ELR13324.1 - 0.16 11.8 0.2 0.24 11.2 0.2 1.2 1 0 0 1 1 1 0 Initiator Replication protein zf-MYND PF01753.18 ELR13325.1 - 1.2e-08 34.8 14.8 3.7e-08 33.3 14.8 1.9 1 1 0 1 1 1 1 MYND finger RhoGEF PF00621.20 ELR13326.1 - 1.6e-42 145.8 5.2 2.7e-42 145.1 5.2 1.4 1 0 0 1 1 1 1 RhoGEF domain PH PF00169.29 ELR13326.1 - 0.00035 21.1 0.2 0.018 15.6 0.0 3.5 3 2 0 3 3 3 1 PH domain Ribosomal_S15 PF00312.22 ELR13326.1 - 0.011 15.9 0.1 0.04 14.1 0.1 2.0 1 0 0 1 1 1 0 Ribosomal protein S15 PH_16 PF17838.1 ELR13326.1 - 0.062 13.1 0.3 1.3 8.9 0.0 2.9 2 2 0 2 2 2 0 PH domain IQ PF00612.27 ELR13326.1 - 0.07 13.0 1.5 0.19 11.6 1.5 1.7 1 0 0 1 1 1 0 IQ calmodulin-binding motif DUF525 PF04379.14 ELR13327.1 - 1.7e-24 85.8 0.1 2.9e-24 85.1 0.1 1.3 1 0 0 1 1 1 1 ApaG domain Arf PF00025.21 ELR13328.1 - 1.5e-55 187.3 0.0 1.8e-55 187.1 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family G-alpha PF00503.20 ELR13328.1 - 4.6e-10 39.2 0.0 8.1e-09 35.1 0.0 2.2 1 1 1 2 2 2 1 G-protein alpha subunit Roc PF08477.13 ELR13328.1 - 3.9e-08 33.5 0.0 1.1e-07 32.1 0.0 1.8 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 ELR13328.1 - 6.1e-08 32.3 0.0 7.5e-08 32.0 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Ras PF00071.22 ELR13328.1 - 1.9e-07 30.8 0.0 2.7e-07 30.3 0.0 1.2 1 0 0 1 1 1 1 Ras family MMR_HSR1 PF01926.23 ELR13328.1 - 4.8e-07 29.9 0.0 1e-06 28.8 0.0 1.5 2 0 0 2 2 2 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 ELR13328.1 - 5.1e-05 22.7 0.0 7.1e-05 22.3 0.0 1.3 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 ELR13328.1 - 0.00013 21.6 0.0 0.013 15.1 0.0 2.1 2 0 0 2 2 2 2 Elongation factor Tu GTP binding domain PduV-EutP PF10662.9 ELR13328.1 - 0.084 12.6 0.1 0.55 10.0 0.0 2.1 2 1 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation RhoGEF PF00621.20 ELR13329.1 - 2e-39 135.7 0.1 4.1e-39 134.7 0.1 1.6 1 0 0 1 1 1 1 RhoGEF domain PH_10 PF15411.6 ELR13329.1 - 1.5 9.1 0.0 1.5 9.1 0.0 3.7 5 0 0 5 5 5 0 Pleckstrin homology domain EIF_2_alpha PF07541.12 ELR13330.1 - 4.4e-11 42.9 0.0 7.3e-11 42.2 0.0 1.3 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 2 alpha subunit S1 PF00575.23 ELR13330.1 - 0.0002 21.6 0.2 0.00035 20.9 0.2 1.5 1 0 0 1 1 1 1 S1 RNA binding domain SelB-wing_3 PF09107.11 ELR13330.1 - 0.075 12.7 0.0 0.14 11.8 0.0 1.5 1 0 0 1 1 1 0 Elongation factor SelB, winged helix ubiquitin PF00240.23 ELR13331.1 - 6.2e-102 333.4 14.4 2.7e-34 116.8 0.7 3.0 2 1 1 3 3 3 3 Ubiquitin family Rad60-SLD PF11976.8 ELR13331.1 - 3.7e-49 164.4 13.9 2.1e-16 59.5 0.8 3.0 2 1 1 3 3 3 3 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 ELR13331.1 - 2.7e-19 69.4 6.6 5.8e-05 23.5 0.2 4.6 2 2 1 3 3 3 3 Ubiquitin-like domain TBK1_ULD PF18396.1 ELR13331.1 - 2.8e-13 49.6 1.3 0.0082 16.0 0.1 3.3 2 1 1 3 3 3 3 TANK binding kinase 1 ubiquitin-like domain DUF2407 PF10302.9 ELR13331.1 - 3.2e-12 46.9 0.5 0.036 14.6 0.0 3.1 1 1 1 3 3 3 3 DUF2407 ubiquitin-like domain Rad60-SLD_2 PF13881.6 ELR13331.1 - 1.3e-11 44.6 2.1 0.034 14.3 0.1 4.0 2 2 1 3 3 3 3 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_5 PF18037.1 ELR13331.1 - 3.6e-11 43.3 5.6 0.014 15.7 0.1 3.1 1 1 2 3 3 3 3 Ubiquitin-like domain DUF3861 PF12977.7 ELR13331.1 - 4.6e-06 26.7 1.6 2.6 8.3 0.1 3.2 3 0 0 3 3 3 3 Domain of Unknown Function with PDB structure (DUF3861) Ubiquitin_4 PF18036.1 ELR13331.1 - 7.9e-06 25.8 16.7 4.7 7.3 0.2 6.0 5 1 1 6 6 6 2 Ubiquitin-like domain Sde2_N_Ubi PF13019.6 ELR13331.1 - 3.3e-05 23.8 0.2 0.95 9.3 0.0 3.1 2 1 1 3 3 3 2 Silencing defective 2 N-terminal ubiquitin domain DUF2870 PF11069.8 ELR13331.1 - 0.0012 19.1 0.0 31 5.0 0.0 3.6 3 0 0 3 3 3 0 Protein of unknown function (DUF2870) Raf1_HTH PF18579.1 ELR13331.1 - 0.0019 17.9 0.5 24 4.7 0.0 3.3 3 0 0 3 3 3 0 Rubisco accumulation factor 1 helix turn helix domain Big_3_3 PF13750.6 ELR13331.1 - 0.0021 17.7 0.2 6.3 6.4 0.1 3.1 2 1 1 3 3 3 0 Bacterial Ig-like domain (group 3) ACT_5 PF13710.6 ELR13331.1 - 0.0035 17.2 3.8 12 5.8 0.1 3.3 3 0 0 3 3 3 0 ACT domain ACT_4 PF13291.6 ELR13331.1 - 0.0044 17.6 0.9 38 5.0 0.1 3.3 3 0 0 3 3 3 0 ACT domain DUF493 PF04359.14 ELR13331.1 - 0.0051 17.4 0.1 48 4.6 0.0 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF493) Plexin_cytopl PF08337.12 ELR13331.1 - 0.0057 15.4 10.6 0.46 9.1 0.2 4.0 4 1 1 5 5 5 2 Plexin cytoplasmic RasGAP domain Big_7 PF17957.1 ELR13331.1 - 0.0065 17.2 0.0 60 4.5 0.0 3.1 3 0 0 3 3 3 0 Bacterial Ig domain DUF1866 PF08952.11 ELR13331.1 - 0.007 16.2 0.3 32 4.3 0.0 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF1866) RBD PF02196.15 ELR13331.1 - 0.0095 16.0 0.0 51 4.1 0.0 3.3 3 0 0 3 3 3 0 Raf-like Ras-binding domain ProRS-C_2 PF09181.10 ELR13331.1 - 0.041 14.0 3.7 39 4.5 0.1 3.2 3 0 0 3 3 3 0 Prolyl-tRNA synthetase, C-terminal UDP-g_GGTase PF06427.11 ELR13331.1 - 0.048 13.8 2.5 2.9 8.0 0.1 3.2 3 0 0 3 3 3 0 UDP-glucose:Glycoprotein Glucosyltransferase Coagulin PF02035.15 ELR13331.1 - 0.052 13.4 1.7 38 4.1 0.0 3.1 3 0 0 3 3 3 0 Coagulin Acp26Ab PF05777.12 ELR13331.1 - 0.072 13.7 2.4 6.6 7.4 0.0 4.0 4 1 0 4 4 4 0 Drosophila accessory gland-specific peptide 26Ab (Acp26Ab) YukD PF08817.10 ELR13331.1 - 0.088 13.5 0.1 1.3e+02 3.4 0.0 3.2 3 0 0 3 3 3 0 WXG100 protein secretion system (Wss), protein YukD PI3K_p85B PF02192.16 ELR13331.1 - 0.1 12.3 7.0 20 5.0 0.2 3.3 3 0 0 3 3 3 0 PI3-kinase family, p85-binding domain Tash_PEST PF07708.11 ELR13331.1 - 0.12 12.6 18.4 4.3 7.6 1.5 3.3 3 0 0 3 3 3 0 Tash protein PEST motif Phage_sheath_1N PF17481.2 ELR13331.1 - 0.23 11.9 4.0 83 3.7 4.0 3.0 1 1 0 1 1 1 0 Phage tail sheath protein beta-sandwich domain Myosin_N PF02736.19 ELR13331.1 - 1.4 8.8 4.1 72 3.3 0.0 3.9 3 0 0 3 3 3 0 Myosin N-terminal SH3-like domain rRNA_processing PF08524.11 ELR13333.1 - 3 7.8 29.7 4.9 7.2 29.7 1.3 1 0 0 1 1 1 0 rRNA processing Presenilin PF01080.17 ELR13333.1 - 4.3 6.0 18.2 5.1 5.7 18.2 1.0 1 0 0 1 1 1 0 Presenilin DUF4661 PF15576.6 ELR13333.1 - 5 7.0 7.1 5.9 6.7 7.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4661) COX17 PF05051.13 ELR13334.1 - 3e-17 62.7 7.4 3.6e-17 62.4 7.4 1.1 1 0 0 1 1 1 1 Cytochrome C oxidase copper chaperone (COX17) RNase_P_Rpp14 PF01900.19 ELR13335.1 - 3.9e-09 36.7 0.0 5.3e-09 36.2 0.0 1.1 1 0 0 1 1 1 1 Rpp14/Pop5 family RabGAP-TBC PF00566.18 ELR13336.1 - 2.6e-40 138.4 0.0 2.6e-40 138.4 0.0 1.7 2 0 0 2 2 2 1 Rab-GTPase-TBC domain Ribosomal_60s PF00428.19 ELR13336.1 - 0.22 12.1 0.2 0.22 12.1 0.2 4.7 4 0 0 4 4 4 0 60s Acidic ribosomal protein CDC45 PF02724.14 ELR13336.1 - 0.45 8.7 17.0 0.76 8.0 17.0 1.2 1 0 0 1 1 1 0 CDC45-like protein SDA1 PF05285.12 ELR13336.1 - 1.7 8.0 23.4 3.3 7.0 23.4 1.5 1 0 0 1 1 1 0 SDA1 Casc1_N PF15927.5 ELR13336.1 - 4 7.1 17.0 8.2 6.1 17.0 1.5 1 0 0 1 1 1 0 Cancer susceptibility candidate 1 N-terminus adh_short PF00106.25 ELR13337.1 - 7.9e-26 90.7 2.0 6.8e-24 84.4 0.4 2.9 2 1 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.6 ELR13337.1 - 1.2e-18 67.6 6.8 5.8e-16 58.8 2.7 3.8 1 1 1 2 2 2 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ELR13337.1 - 0.063 13.2 0.4 0.12 12.2 0.1 1.6 2 0 0 2 2 2 0 KR domain dCMP_cyt_deam_2 PF08211.12 ELR13338.1 - 4.5e-41 140.2 0.0 9.6e-40 135.9 0.0 2.1 2 0 0 2 2 2 1 Cytidine and deoxycytidylate deaminase zinc-binding region dCMP_cyt_deam_1 PF00383.23 ELR13338.1 - 4.7e-13 48.9 0.4 1.6e-09 37.5 0.0 3.2 3 0 0 3 3 3 2 Cytidine and deoxycytidylate deaminase zinc-binding region SNAD4 PF18750.1 ELR13338.1 - 0.17 12.0 0.6 1 9.5 0.0 2.2 2 0 0 2 2 2 0 Secreted Novel AID/APOBEC-like Deaminase 4 DUF4139 PF13598.6 ELR13339.1 - 8.2e-47 159.6 0.2 1.2e-46 159.1 0.2 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4139) DUF4140 PF13600.6 ELR13339.1 - 1.2e-22 80.1 3.9 1.3e-21 76.8 1.3 2.8 2 0 0 2 2 2 1 N-terminal domain of unknown function (DUF4140) GOLGA2L5 PF15070.6 ELR13339.1 - 0.0085 14.8 0.1 0.014 14.1 0.1 1.3 1 0 0 1 1 1 1 Putative golgin subfamily A member 2-like protein 5 FixH PF05751.11 ELR13339.1 - 0.036 14.1 0.1 0.083 12.9 0.1 1.5 1 0 0 1 1 1 0 FixH MreB_Mbl PF06723.13 ELR13339.1 - 0.04 12.7 0.1 0.068 12.0 0.1 1.3 1 0 0 1 1 1 0 MreB/Mbl protein MipA PF06629.12 ELR13339.1 - 0.063 13.5 0.0 0.18 12.1 0.0 1.7 1 0 0 1 1 1 0 MltA-interacting protein MipA Fungal_TACC PF12709.7 ELR13339.1 - 0.11 13.0 0.2 0.42 11.1 0.1 2.0 2 0 0 2 2 2 0 Fungal Transforming acidic coiled-coil (TACC) proteins Seryl_tRNA_N PF02403.22 ELR13339.1 - 0.64 10.3 4.0 9.4 6.5 0.0 2.6 3 0 0 3 3 3 0 Seryl-tRNA synthetase N-terminal domain Clat_adaptor_s PF01217.20 ELR13340.1 - 8.2e-47 158.7 0.6 9.4e-47 158.5 0.6 1.0 1 0 0 1 1 1 1 Clathrin adaptor complex small chain THF_DHG_CYH_C PF02882.19 ELR13341.1 - 6.6e-45 152.3 1.1 1.1e-44 151.6 1.1 1.3 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain SurE PF01975.17 ELR13342.1 - 2.2e-49 167.9 0.0 3.6e-49 167.2 0.0 1.3 1 1 0 1 1 1 1 Survival protein SurE DUF525 PF04379.14 ELR13343.1 - 7.9e-07 29.2 0.0 1.5e-06 28.4 0.0 1.4 1 0 0 1 1 1 1 ApaG domain 2-Hacid_dh_C PF02826.19 ELR13344.1 - 1.4e-55 187.4 0.0 1.9e-55 187.0 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 ELR13344.1 - 2.1e-26 92.2 0.0 4.8e-24 84.5 0.0 2.2 1 1 0 2 2 2 2 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.15 ELR13344.1 - 1e-07 32.2 0.0 2.1e-07 31.2 0.0 1.5 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase F420_oxidored PF03807.17 ELR13344.1 - 0.00021 21.8 0.0 0.00055 20.5 0.0 1.9 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent XdhC_C PF13478.6 ELR13344.1 - 0.00053 20.5 0.0 0.0023 18.4 0.0 2.1 1 1 0 2 2 2 1 XdhC Rossmann domain IlvN PF07991.12 ELR13344.1 - 0.0014 18.2 0.1 0.0061 16.1 0.0 1.9 2 0 0 2 2 2 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain AdoHcyase_NAD PF00670.21 ELR13344.1 - 0.026 14.6 0.0 0.063 13.3 0.0 1.6 2 0 0 2 2 2 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain DZR PF12773.7 ELR13345.1 - 7.1e-08 32.4 8.8 3.6e-06 26.9 8.9 2.1 1 1 0 1 1 1 1 Double zinc ribbon zinc_ribbon_2 PF13240.6 ELR13345.1 - 0.00068 19.3 17.7 0.0017 18.0 7.2 2.8 3 0 0 3 3 3 2 zinc-ribbon domain LIM PF00412.22 ELR13345.1 - 0.0034 17.6 4.6 0.41 10.9 4.6 2.9 1 1 0 1 1 1 1 LIM domain zf_C2H2_13 PF18508.1 ELR13345.1 - 0.023 14.3 0.7 0.023 14.3 0.7 3.3 3 1 1 4 4 4 0 Zinc finger domain zf-ribbon_3 PF13248.6 ELR13345.1 - 0.08 12.4 16.9 0.24 10.8 0.3 3.3 3 1 0 3 3 3 0 zinc-ribbon domain zf-C4pol PF14260.6 ELR13345.1 - 0.085 13.3 7.0 13 6.3 7.0 2.4 1 1 0 1 1 1 0 C4-type zinc-finger of DNA polymerase delta Nudix_N_2 PF14803.6 ELR13345.1 - 0.087 12.8 13.3 0.54 10.2 0.6 3.6 3 1 0 3 3 3 0 Nudix N-terminal NinF PF05810.12 ELR13345.1 - 0.17 11.8 9.8 2.9 7.8 0.2 3.1 1 1 2 3 3 3 0 NinF protein Rep_fac-A_C PF08646.10 ELR13345.1 - 0.21 11.3 2.5 0.27 11.0 2.5 1.4 1 1 0 1 1 1 0 Replication factor-A C terminal domain HNH_5 PF14279.6 ELR13345.1 - 0.28 11.1 8.3 0.59 10.0 0.1 3.6 2 2 1 4 4 4 0 HNH endonuclease zf-C3HC4_3 PF13920.6 ELR13345.1 - 0.3 11.0 8.8 0.53 10.2 1.4 2.7 1 1 2 3 3 3 0 Zinc finger, C3HC4 type (RING finger) PolC_DP2 PF03833.13 ELR13345.1 - 0.53 8.1 3.6 0.53 8.1 3.6 1.0 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 DUF1258 PF06869.12 ELR13345.1 - 0.97 8.9 3.0 0.37 10.3 0.9 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1258) C1_1 PF00130.22 ELR13345.1 - 1.5 8.7 10.7 6.2e+02 0.4 10.7 3.3 1 1 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) DUF2321 PF10083.9 ELR13345.1 - 2.3 7.8 8.5 0.31 10.7 2.6 2.2 1 1 1 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2321) zinc_ribbon_15 PF17032.5 ELR13345.1 - 2.3 9.0 11.0 0.74 10.6 1.7 2.8 2 1 0 2 2 2 0 zinc-ribbon family YdjO PF14169.6 ELR13345.1 - 2.3 8.0 8.7 0.58 9.9 0.4 2.6 1 1 1 2 2 2 0 Cold-inducible protein YdjO zf_UBZ PF18439.1 ELR13345.1 - 2.4 7.8 11.0 3.4 7.3 0.2 4.0 3 1 1 4 4 4 0 Ubiquitin-Binding Zinc Finger C1_2 PF03107.16 ELR13345.1 - 2.7 8.4 10.4 1.7 9.0 5.3 2.4 1 1 1 2 2 2 0 C1 domain zf-B_box PF00643.24 ELR13345.1 - 5.4 7.3 10.9 21 5.4 0.1 3.7 2 1 0 2 2 2 0 B-box zinc finger zinc_ribbon_9 PF14369.6 ELR13345.1 - 5.5 7.3 8.2 1.4 9.3 0.7 3.0 3 0 0 3 3 3 0 zinc-ribbon zf-MYND PF01753.18 ELR13345.1 - 6 7.1 10.3 5.1e+02 0.9 10.3 2.7 1 1 0 1 1 1 0 MYND finger Sgf11 PF08209.11 ELR13345.1 - 7.9 6.1 10.8 24 4.6 0.2 3.9 2 1 2 4 4 4 0 Sgf11 (transcriptional regulation protein) zf-NADH-PPase PF09297.11 ELR13345.1 - 8 6.2 15.6 1.1 8.9 1.0 3.4 2 1 1 3 3 3 0 NADH pyrophosphatase zinc ribbon domain Ank_2 PF12796.7 ELR13346.1 - 5.2e-16 59.0 1.2 4.9e-05 23.8 0.0 4.6 2 1 3 5 5 5 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ELR13346.1 - 7.9e-15 55.0 4.7 1.1e-05 25.8 0.1 6.3 5 1 1 7 7 7 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 ELR13346.1 - 2.6e-11 42.7 4.7 0.081 13.5 0.1 7.0 7 0 0 7 7 7 4 Ankyrin repeat Ank PF00023.30 ELR13346.1 - 5.4e-08 32.9 6.5 0.034 14.6 0.3 5.7 4 1 0 4 4 4 2 Ankyrin repeat F-box-like PF12937.7 ELR13346.1 - 1.5e-06 28.0 0.6 1.2e-05 25.1 0.1 2.3 2 0 0 2 2 2 1 F-box-like Ank_5 PF13857.6 ELR13346.1 - 4.2e-06 26.9 1.7 0.061 13.7 0.3 4.7 3 2 2 5 5 5 2 Ankyrin repeats (many copies) DPM2 PF07297.12 ELR13347.1 - 1.5e-19 70.0 5.5 1.7e-19 69.8 5.5 1.0 1 0 0 1 1 1 1 Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2) COesterase PF00135.28 ELR13349.1 - 2.8e-21 76.0 0.0 3.3e-21 75.7 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family COesterase PF00135.28 ELR13350.1 - 1.4e-103 347.5 0.0 1.7e-103 347.2 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 ELR13350.1 - 1e-07 32.0 0.0 2.1e-07 31.0 0.0 1.5 1 0 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 ELR13350.1 - 0.0045 16.5 0.0 0.008 15.7 0.0 1.4 1 0 0 1 1 1 1 Prolyl oligopeptidase family WD40 PF00400.32 ELR13351.1 - 1.8e-19 69.7 12.5 1.9e-07 31.6 0.2 5.3 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ELR13351.1 - 2e-10 40.8 1.7 0.0018 18.6 0.3 4.2 2 2 3 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ELR13351.1 - 0.01 14.8 0.0 0.11 11.4 0.0 2.1 2 0 0 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Methyltr_RsmB-F PF01189.17 ELR13352.1 - 1.3e-42 145.7 0.0 2.1e-42 145.1 0.0 1.3 1 0 0 1 1 1 1 16S rRNA methyltransferase RsmB/F PUA PF01472.20 ELR13352.1 - 3.9e-10 39.5 0.2 6.8e-10 38.8 0.2 1.4 1 0 0 1 1 1 1 PUA domain Methyltransf_31 PF13847.6 ELR13352.1 - 4.4e-06 26.6 0.0 7e-06 25.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain FtsJ PF01728.19 ELR13352.1 - 0.0038 17.4 0.0 0.013 15.7 0.0 1.8 1 1 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_25 PF13649.6 ELR13352.1 - 0.059 14.1 0.1 0.58 10.9 0.0 2.4 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_25 PF13649.6 ELR13354.1 - 7.4e-10 39.4 2.0 2.4e-09 37.8 1.1 2.2 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 ELR13354.1 - 6e-08 33.2 3.4 9.2e-07 29.4 2.3 2.6 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 ELR13354.1 - 8.6e-06 25.6 0.5 2.1e-05 24.4 0.5 1.7 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 ELR13354.1 - 8.7e-06 25.2 1.6 2.5e-05 23.7 0.7 2.2 2 1 0 2 2 2 1 ubiE/COQ5 methyltransferase family Methyltransf_20 PF12147.8 ELR13354.1 - 0.00013 21.2 0.0 0.0002 20.6 0.0 1.2 1 0 0 1 1 1 1 Putative methyltransferase UPF0020 PF01170.18 ELR13354.1 - 0.00015 21.5 0.6 0.0019 17.9 0.1 2.3 2 1 0 2 2 2 1 Putative RNA methylase family UPF0020 Methyltransf_12 PF08242.12 ELR13354.1 - 0.001 19.8 0.1 0.0026 18.5 0.1 1.7 1 1 0 1 1 1 1 Methyltransferase domain Met_10 PF02475.16 ELR13354.1 - 0.011 15.5 0.0 0.014 15.1 0.0 1.3 1 0 0 1 1 1 0 Met-10+ like-protein FtsJ PF01728.19 ELR13354.1 - 0.04 14.0 0.8 0.15 12.2 0.4 1.8 1 1 1 2 2 2 0 FtsJ-like methyltransferase MTS PF05175.14 ELR13354.1 - 0.056 13.0 0.5 0.92 9.0 0.2 2.3 2 0 0 2 2 2 0 Methyltransferase small domain Methyltransf_18 PF12847.7 ELR13354.1 - 0.15 12.0 0.1 0.23 11.4 0.1 1.3 1 0 0 1 1 1 0 Methyltransferase domain Mob1_phocein PF03637.17 ELR13355.1 - 4.7e-80 267.5 0.1 5.9e-80 267.2 0.1 1.0 1 0 0 1 1 1 1 Mob1/phocein family Cu-oxidase_3 PF07732.15 ELR13356.1 - 9.2e-05 22.4 0.0 0.00026 21.0 0.0 1.7 1 0 0 1 1 1 1 Multicopper oxidase Renin_r PF07850.14 ELR13356.1 - 0.011 16.3 0.2 0.025 15.2 0.2 1.5 1 0 0 1 1 1 0 Renin receptor-like protein DUF2149 PF09919.9 ELR13356.1 - 0.13 12.6 0.0 0.29 11.4 0.0 1.5 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2149) FtsJ PF01728.19 ELR13357.1 - 8.2e-11 42.3 0.0 1.8e-10 41.2 0.0 1.6 2 0 0 2 2 2 1 FtsJ-like methyltransferase Methyltransf_23 PF13489.6 ELR13357.1 - 0.0054 16.6 0.0 0.0094 15.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltr_RsmB-F PF01189.17 ELR13357.1 - 0.011 15.4 0.0 0.05 13.2 0.0 2.0 1 1 0 2 2 2 0 16S rRNA methyltransferase RsmB/F TPR_MLP1_2 PF07926.12 ELR13358.1 - 3.3e-20 72.4 27.5 3.3e-20 72.4 27.5 15.5 8 5 6 15 15 15 5 TPR/MLP1/MLP2-like protein Mod_r PF07200.13 ELR13358.1 - 0.0011 19.1 17.1 0.0011 19.1 17.1 15.4 5 3 10 15 15 15 1 Modifier of rudimentary (Mod(r)) protein MscS_porin PF12795.7 ELR13358.1 - 0.0035 16.9 18.8 0.0035 16.9 18.8 11.6 3 2 5 11 11 11 2 Mechanosensitive ion channel porin domain PQQ_2 PF13360.6 ELR13359.1 - 0.00022 20.9 1.7 1.4 8.4 0.1 3.2 2 1 1 3 3 3 3 PQQ-like domain T4BSS_DotH_IcmK PF12293.8 ELR13359.1 - 0.15 11.3 0.9 1.3 8.2 0.2 2.1 2 0 0 2 2 2 0 Putative outer membrane core complex of type IVb secretion PhyH PF05721.13 ELR13361.1 - 0.015 15.6 0.8 0.021 15.1 0.4 1.5 2 0 0 2 2 2 0 Phytanoyl-CoA dioxygenase (PhyH) Acyl-CoA_dh_1 PF00441.24 ELR13362.1 - 3.1e-27 95.6 0.5 5.9e-27 94.7 0.5 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.16 ELR13362.1 - 5.3e-27 94.7 0.0 1e-26 93.8 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.19 ELR13362.1 - 4.4e-23 81.3 0.1 9.4e-23 80.2 0.1 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.11 ELR13362.1 - 1.4e-07 31.8 0.2 5e-07 30.1 0.0 2.0 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_ox_N PF14749.6 ELR13362.1 - 0.14 12.7 0.0 0.26 11.9 0.0 1.5 1 0 0 1 1 1 0 Acyl-coenzyme A oxidase N-terminal DUF5516 PF17637.2 ELR13363.1 - 0.011 15.5 12.6 0.27 11.0 2.5 2.5 2 0 0 2 2 2 0 Family of unknown function (DUF5516) Fumarate_red_D PF02313.17 ELR13365.1 - 0.0048 17.0 0.0 0.0048 17.0 0.0 2.2 2 0 0 2 2 2 1 Fumarate reductase subunit D EcsC PF12787.7 ELR13365.1 - 1.4 8.6 5.7 3.1 7.4 0.3 2.7 2 1 1 3 3 3 0 EcsC protein family EFG_C PF00679.24 ELR13366.1 - 1.5e-20 73.0 0.0 3.2e-20 72.0 0.0 1.6 1 0 0 1 1 1 1 Elongation factor G C-terminus EFG_II PF14492.6 ELR13366.1 - 4e-17 62.1 0.0 7.7e-17 61.2 0.0 1.4 1 0 0 1 1 1 1 Elongation Factor G, domain II GTP_EFTU_D2 PF03144.25 ELR13366.1 - 9.3e-10 38.8 0.0 1.9e-09 37.8 0.0 1.5 1 0 0 1 1 1 1 Elongation factor Tu domain 2 EFG_IV PF03764.18 ELR13366.1 - 5e-07 29.5 0.1 1.8e-05 24.5 0.1 2.4 1 1 1 2 2 2 1 Elongation factor G, domain IV RF3_C PF16658.5 ELR13366.1 - 0.14 12.0 0.0 0.26 11.1 0.0 1.4 1 0 0 1 1 1 0 Class II release factor RF3, C-terminal domain GTP_EFTU PF00009.27 ELR13367.1 - 4.1e-37 127.6 0.0 5.1e-37 127.3 0.0 1.1 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 ELR13367.1 - 0.0011 19.0 0.0 0.0028 17.7 0.0 1.6 1 1 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.10 ELR13367.1 - 0.15 11.5 0.0 0.2 11.1 0.0 1.5 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit Kin17_mid PF10357.9 ELR13368.1 - 9.4e-32 109.6 8.8 9.4e-32 109.6 8.8 3.5 3 1 0 3 3 3 1 Domain of Kin17 curved DNA-binding protein KN17_SH3 PF18131.1 ELR13368.1 - 7e-14 51.7 2.8 8.6e-12 45.0 2.1 2.3 2 0 0 2 2 2 1 KN17 SH3-like C-terminal domain SR-25 PF10500.9 ELR13368.1 - 0.00049 19.8 25.0 0.00049 19.8 25.0 2.1 2 0 0 2 2 2 1 Nuclear RNA-splicing-associated protein zf-C2H2_jaz PF12171.8 ELR13368.1 - 0.0081 16.4 5.9 0.017 15.4 5.9 1.6 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 ELR13368.1 - 0.022 15.1 6.3 0.022 15.1 6.3 1.8 2 0 0 2 2 2 0 Zinc-finger of C2H2 type Peptidase_S64 PF08192.11 ELR13368.1 - 0.21 10.0 6.2 0.33 9.4 6.2 1.2 1 0 0 1 1 1 0 Peptidase family S64 KOW PF00467.29 ELR13368.1 - 0.42 10.6 3.6 0.87 9.6 0.0 3.0 3 0 0 3 3 3 0 KOW motif PI3K_1B_p101 PF10486.9 ELR13368.1 - 4.3 5.0 14.3 6.7 4.4 14.3 1.2 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit LRIF1 PF15741.5 ELR13368.1 - 5.2 5.5 16.2 9.8 4.6 16.2 1.4 1 0 0 1 1 1 0 Ligand-dependent nuclear receptor-interacting factor 1 p450 PF00067.22 ELR13369.1 - 2e-86 290.6 0.0 2.5e-86 290.3 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 ASC PF00858.24 ELR13370.1 - 3.3e-07 29.6 0.5 0.017 14.1 0.1 2.4 2 1 0 2 2 2 2 Amiloride-sensitive sodium channel DUF3586 PF12131.8 ELR13370.1 - 0.0031 17.7 1.6 3.3 8.0 0.1 2.8 2 0 0 2 2 2 2 Protein of unknown function (DUF3586) HisKA_4TM PF16926.5 ELR13370.1 - 0.0032 17.1 2.5 1.5 8.3 0.2 2.4 2 0 0 2 2 2 2 Archaeal 4TM region of histidine kinase 3Beta_HSD PF01073.19 ELR13370.1 - 0.01 14.9 0.2 3 6.8 0.1 2.2 2 0 0 2 2 2 2 3-beta hydroxysteroid dehydrogenase/isomerase family WSC PF01822.19 ELR13370.1 - 0.015 15.5 0.9 4.8 7.4 0.1 2.7 2 0 0 2 2 2 0 WSC domain aGPT-Pplase3 PF18746.1 ELR13370.1 - 0.053 12.9 0.0 10 5.4 0.0 2.3 2 0 0 2 2 2 0 Alpha-glutamyl/putrescinyl thymine pyrophosphorylase clade 3 BetR PF08667.10 ELR13370.1 - 0.13 12.3 0.1 12 5.9 0.0 2.5 2 0 0 2 2 2 0 BetR domain DUF2834 PF11196.8 ELR13370.1 - 0.3 11.5 3.2 16 5.9 0.3 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2834) DUF3605 PF12239.8 ELR13372.1 - 6.3e-13 49.3 0.0 6.8e-11 42.7 0.0 2.1 1 1 0 1 1 1 1 Protein of unknown function (DUF3605) Kinesin PF00225.23 ELR13373.1 - 2.5e-24 85.8 0.5 3e-24 85.6 0.5 1.3 1 1 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 ELR13373.1 - 3.3e-16 59.6 0.0 5.1e-16 58.9 0.0 1.3 1 0 0 1 1 1 1 Microtubule binding UpxZ PF06603.11 ELR13373.1 - 0.024 14.9 0.0 0.14 12.4 0.0 2.0 1 1 1 2 2 2 0 UpxZ family of transcription anti-terminator antagonists CASP_C PF08172.12 ELR13373.1 - 0.23 10.8 2.1 0.44 9.9 2.1 1.4 1 0 0 1 1 1 0 CASP C terminal MID_MedPIWI PF18296.1 ELR13373.1 - 0.56 9.9 10.5 1.3 8.8 10.5 1.7 1 1 0 1 1 1 0 MID domain of medPIWI ROK PF00480.20 ELR13374.1 - 1.7e-51 175.4 0.0 2.1e-51 175.2 0.0 1.1 1 0 0 1 1 1 1 ROK family MOSC_N PF03476.16 ELR13375.1 - 4.3e-21 75.0 0.0 1.1e-20 73.7 0.0 1.7 1 0 0 1 1 1 1 MOSC N-terminal beta barrel domain MOSC PF03473.17 ELR13375.1 - 8.3e-09 35.6 0.0 1.7e-08 34.5 0.0 1.5 1 0 0 1 1 1 1 MOSC domain Aminotran_5 PF00266.19 ELR13375.1 - 9.7e-07 28.1 0.0 0.00013 21.1 0.0 2.2 1 1 1 2 2 2 2 Aminotransferase class-V F-box-like PF12937.7 ELR13375.1 - 1.4e-05 24.8 0.1 4.2e-05 23.4 0.0 1.8 2 0 0 2 2 2 1 F-box-like Clat_adaptor_s PF01217.20 ELR13377.1 - 1.4e-15 57.5 0.2 2.6e-15 56.6 0.1 1.5 1 1 1 2 2 2 1 Clathrin adaptor complex small chain DUF2577 PF10844.8 ELR13377.1 - 0.14 12.4 0.1 0.24 11.6 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2577) TrmO PF01980.16 ELR13378.1 - 6.4e-46 155.4 0.0 9e-46 155.0 0.0 1.2 1 0 0 1 1 1 1 tRNA-methyltransferase O MYO10_CC PF16735.5 ELR13378.1 - 0.023 14.8 1.4 0.023 14.8 1.4 1.7 2 0 0 2 2 2 0 Unconventional myosin-X coiled coil domain NCBP3 PF10309.9 ELR13378.1 - 0.083 12.8 0.0 0.32 10.9 0.0 1.9 2 0 0 2 2 2 0 Nuclear cap-binding protein subunit 3 DUF1192 PF06698.11 ELR13378.1 - 0.81 9.8 4.6 1.8 8.7 4.6 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1192) LRR_4 PF12799.7 ELR13379.1 - 0.00022 21.5 2.0 0.014 15.8 0.2 2.3 1 1 1 2 2 2 2 Leucine Rich repeats (2 copies) WW PF00397.26 ELR13380.1 - 1.3e-24 85.9 20.9 7.3e-09 35.6 2.7 3.9 4 0 0 4 4 4 3 WW domain Glyco_hyd_101C PF17451.2 ELR13380.1 - 0.059 13.6 7.3 0.11 12.7 1.3 3.2 2 1 1 3 3 3 0 Glycosyl hydrolase 101 beta sandwich domain Syja_N PF02383.18 ELR13381.1 - 2.1e-19 70.0 0.0 1.2e-10 41.2 0.0 3.0 1 1 2 3 3 3 2 SacI homology domain FYVE PF01363.21 ELR13381.1 - 0.0032 17.6 9.1 0.006 16.7 9.1 1.4 1 0 0 1 1 1 1 FYVE zinc finger FYVE_2 PF02318.16 ELR13381.1 - 0.071 13.3 5.0 0.15 12.2 5.0 1.6 1 0 0 1 1 1 0 FYVE-type zinc finger CH PF00307.31 ELR13382.1 - 1.2e-37 128.4 0.3 7.5e-19 67.9 0.0 2.4 2 0 0 2 2 2 2 Calponin homology (CH) domain CAMSAP_CH PF11971.8 ELR13382.1 - 2e-12 46.8 0.1 6.2e-06 26.0 0.0 2.6 2 0 0 2 2 2 2 CAMSAP CH domain LRR_4 PF12799.7 ELR13382.1 - 2.5e-08 34.1 16.5 0.27 11.7 0.0 7.9 6 2 3 9 9 9 4 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 ELR13382.1 - 0.00011 22.2 2.4 55 4.9 0.0 6.4 6 0 0 6 6 6 0 Leucine Rich Repeat LRR_8 PF13855.6 ELR13382.1 - 0.014 15.1 13.7 0.3 10.9 0.3 5.3 6 0 0 6 6 6 0 Leucine rich repeat LRR_9 PF14580.6 ELR13382.1 - 0.031 13.8 12.5 1 8.8 0.2 4.5 3 2 1 4 4 4 0 Leucine-rich repeat CH_2 PF06294.11 ELR13382.1 - 0.1 12.7 0.0 0.28 11.3 0.0 1.7 1 0 0 1 1 1 0 CH-like domain in sperm protein LRR_6 PF13516.6 ELR13382.1 - 2.2 8.5 8.1 42 4.6 0.0 5.6 6 0 0 6 6 6 0 Leucine Rich repeat RVT_2 PF07727.14 ELR13383.1 - 1e-08 35.1 0.3 2.9e-08 33.7 0.2 1.7 1 1 1 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) Glycos_transf_2 PF00535.26 ELR13386.1 - 1.3e-20 73.9 0.1 2.2e-20 73.2 0.1 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 ELR13386.1 - 1.3e-09 38.2 0.6 2.7e-09 37.3 0.6 1.4 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_2 PF10111.9 ELR13386.1 - 2.8e-05 23.7 0.1 4.3e-05 23.1 0.1 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 PH PF00169.29 ELR13389.1 - 7.1e-05 23.3 0.0 9.1e-05 22.9 0.0 1.2 1 0 0 1 1 1 1 PH domain PH_16 PF17838.1 ELR13389.1 - 0.0027 17.6 0.0 0.0038 17.1 0.0 1.2 1 0 0 1 1 1 1 PH domain PH_2 PF08458.10 ELR13389.1 - 0.023 15.0 0.0 0.029 14.7 0.0 1.2 1 0 0 1 1 1 0 Plant pleckstrin homology-like region PH_13 PF16652.5 ELR13389.1 - 0.029 14.2 0.1 0.2 11.5 0.1 1.9 1 1 0 1 1 1 0 Pleckstrin homology domain PH_10 PF15411.6 ELR13389.1 - 0.038 14.3 0.3 0.24 11.7 0.3 2.0 1 1 0 1 1 1 0 Pleckstrin homology domain PH_11 PF15413.6 ELR13389.1 - 0.1 13.0 0.0 0.13 12.7 0.0 1.3 1 0 0 1 1 1 0 Pleckstrin homology domain SUZ PF12752.7 ELR13391.1 - 2.4e-11 44.2 2.0 2.4e-11 44.2 2.0 3.6 2 2 0 2 2 2 1 SUZ domain API5 PF05918.11 ELR13391.1 - 1.9 7.2 7.6 2.4 6.9 7.6 1.1 1 0 0 1 1 1 0 Apoptosis inhibitory protein 5 (API5) GRP PF07172.11 ELR13391.1 - 2.1 9.1 13.0 3.5 8.4 13.0 1.3 1 0 0 1 1 1 0 Glycine rich protein family Ras PF00071.22 ELR13392.1 - 1.7e-59 200.0 3.2 5.4e-23 81.4 0.0 3.0 3 0 0 3 3 3 3 Ras family Roc PF08477.13 ELR13392.1 - 7.2e-19 68.2 0.0 3.5e-17 62.7 0.0 2.7 3 0 0 3 3 3 1 Ras of Complex, Roc, domain of DAPkinase RsgA_GTPase PF03193.16 ELR13392.1 - 8.8e-06 25.7 1.1 0.15 11.9 0.0 3.1 3 0 0 3 3 3 1 RsgA GTPase Arf PF00025.21 ELR13392.1 - 2.2e-05 24.0 0.2 8.9e-05 22.0 0.0 1.9 2 1 0 2 2 2 1 ADP-ribosylation factor family FeoB_N PF02421.18 ELR13392.1 - 0.00028 20.5 0.1 5.1 6.6 0.0 3.1 3 0 0 3 3 3 1 Ferrous iron transport protein B MMR_HSR1 PF01926.23 ELR13392.1 - 0.0019 18.3 0.0 0.0027 17.8 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_16 PF13191.6 ELR13392.1 - 0.0088 16.4 0.0 0.013 15.9 0.0 1.7 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 ELR13392.1 - 0.017 15.4 0.0 0.043 14.1 0.0 2.0 1 1 0 1 1 1 0 AAA domain AAA_7 PF12775.7 ELR13392.1 - 0.037 13.6 0.0 0.25 10.8 0.0 2.2 2 1 1 3 3 3 0 P-loop containing dynein motor region Gtr1_RagA PF04670.12 ELR13392.1 - 0.039 13.3 0.0 0.062 12.6 0.0 1.3 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region AAA_29 PF13555.6 ELR13392.1 - 0.042 13.6 0.0 0.12 12.2 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain Septin PF00735.18 ELR13392.1 - 0.05 12.9 0.0 0.12 11.7 0.0 1.5 1 0 0 1 1 1 0 Septin NACHT PF05729.12 ELR13392.1 - 0.075 12.9 0.0 0.31 10.9 0.0 2.0 2 0 0 2 2 2 0 NACHT domain MCM PF00493.23 ELR13392.1 - 0.076 12.1 0.0 0.13 11.3 0.0 1.3 1 0 0 1 1 1 0 MCM P-loop domain Ints3 PF10189.9 ELR13392.1 - 0.089 12.1 0.0 13 4.9 0.0 2.1 2 0 0 2 2 2 0 Integrator complex subunit 3 TniB PF05621.11 ELR13392.1 - 0.11 11.9 0.0 0.31 10.4 0.0 1.7 1 0 0 1 1 1 0 Bacterial TniB protein Ank_2 PF12796.7 ELR13393.1 - 6.5e-14 52.3 1.6 5.6e-07 30.1 0.0 3.4 4 0 0 4 4 4 2 Ankyrin repeats (3 copies) F-box-like PF12937.7 ELR13393.1 - 3.3e-12 46.1 1.4 6.2e-12 45.2 1.4 1.5 1 0 0 1 1 1 1 F-box-like Ank_3 PF13606.6 ELR13393.1 - 1.2e-09 37.6 2.5 0.076 13.6 0.0 5.3 5 0 0 5 5 5 2 Ankyrin repeat Ank PF00023.30 ELR13393.1 - 2.4e-09 37.2 2.7 0.0035 17.7 0.1 4.3 4 0 0 4 4 4 2 Ankyrin repeat Ank_5 PF13857.6 ELR13393.1 - 1.4e-08 34.8 0.9 0.0092 16.3 0.0 3.9 3 1 1 4 4 4 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 ELR13393.1 - 5.2e-08 33.3 0.1 0.003 18.1 0.0 3.8 2 1 1 3 3 3 2 Ankyrin repeats (many copies) F-box PF00646.33 ELR13393.1 - 7.4e-07 28.9 0.1 1.3e-06 28.1 0.1 1.5 1 0 0 1 1 1 1 F-box domain Ribosomal_60s PF00428.19 ELR13393.1 - 3.5 8.3 7.6 0.55 10.9 2.5 2.1 2 0 0 2 2 2 0 60s Acidic ribosomal protein Amino_oxidase PF01593.24 ELR13394.1 - 5e-05 22.8 0.4 0.0021 17.4 0.0 2.1 2 0 0 2 2 2 2 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 ELR13394.1 - 0.044 14.0 0.2 0.24 11.7 0.0 2.3 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain RhoGAP PF00620.27 ELR13396.1 - 2.7e-20 72.8 0.0 1.8e-19 70.1 0.0 2.2 2 1 0 2 2 2 1 RhoGAP domain MyTH4 PF00784.17 ELR13396.1 - 2.1e-19 70.0 0.6 5.9e-19 68.5 0.0 2.0 3 0 0 3 3 3 1 MyTH4 domain Ank_4 PF13637.6 ELR13401.1 - 1.1e-10 41.8 6.6 0.094 13.3 0.6 6.0 4 1 2 6 6 6 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 ELR13401.1 - 8.9e-06 26.2 0.1 0.059 14.0 0.0 3.8 1 1 2 3 3 3 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 ELR13401.1 - 3.4e-05 24.0 3.7 29 5.2 0.0 6.7 4 2 3 7 7 7 0 Ankyrin repeats (many copies) F-box PF00646.33 ELR13401.1 - 0.00016 21.5 0.5 0.00027 20.7 0.5 1.3 1 0 0 1 1 1 1 F-box domain Bd3614-deam PF14439.6 ELR13401.1 - 0.016 15.3 1.7 0.016 15.3 1.7 2.1 2 0 0 2 2 2 0 Bd3614-like deaminase DUF4653 PF15546.6 ELR13401.1 - 0.079 12.6 0.2 0.73 9.4 0.0 2.4 3 0 0 3 3 3 0 Domain of unknown function (DUF4653) DUF4224 PF13986.6 ELR13401.1 - 0.14 12.0 4.1 35 4.4 0.1 4.1 4 0 0 4 4 4 0 Domain of unknown function (DUF4224) L27_1 PF09058.10 ELR13402.1 - 0.1 12.6 0.2 0.74 9.8 0.1 2.1 2 0 0 2 2 2 0 L27_1 eRF1_2 PF03464.15 ELR13404.1 - 8.5e-32 110.3 0.0 1.5e-31 109.5 0.0 1.4 1 0 0 1 1 1 1 eRF1 domain 2 eRF1_3 PF03465.15 ELR13404.1 - 3e-24 85.7 0.0 2e-23 83.0 0.0 2.2 2 0 0 2 2 2 1 eRF1 domain 3 eRF1_1 PF03463.15 ELR13404.1 - 1.4e-07 31.5 0.0 2.4e-07 30.8 0.0 1.3 1 0 0 1 1 1 1 eRF1 domain 1 baeRF_family10 PF18854.1 ELR13404.1 - 5.4e-05 23.5 0.1 0.00014 22.1 0.1 1.7 1 0 0 1 1 1 1 Bacterial archaeo-eukaryotic release factor family 10 acVLRF1 PF18859.1 ELR13404.1 - 0.037 14.3 0.1 0.075 13.3 0.1 1.5 1 0 0 1 1 1 0 Actinobacteria/chloroflexi VLRF1 release factor RasGAP PF00616.19 ELR13405.1 - 6.8e-22 78.2 0.0 1.1e-21 77.5 0.0 1.3 1 0 0 1 1 1 1 GTPase-activator protein for Ras-like GTPase FAT PF02259.23 ELR13405.1 - 8.7e-21 74.5 3.2 5.7e-20 71.8 3.2 2.0 1 1 0 1 1 1 1 FAT domain Laminin_G_3 PF13385.6 ELR13405.1 - 1e-10 42.0 0.1 1e-10 42.0 0.1 3.6 4 1 0 4 4 4 1 Concanavalin A-like lectin/glucanases superfamily Ig_3 PF13927.6 ELR13405.1 - 0.012 16.2 0.0 0.035 14.7 0.0 1.8 1 0 0 1 1 1 0 Immunoglobulin domain DUF957 PF06117.11 ELR13405.1 - 0.14 11.8 0.1 0.32 10.6 0.1 1.6 1 0 0 1 1 1 0 Enterobacterial protein of unknown function (DUF957) SgrT PF15894.5 ELR13406.1 - 0.012 15.6 0.1 0.02 14.9 0.1 1.3 1 0 0 1 1 1 0 Inhibitor of glucose uptake transporter SgrT Metallophos PF00149.28 ELR13407.1 - 1.7e-17 64.6 1.5 2.5e-17 64.1 1.5 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase PCI PF01399.27 ELR13408.1 - 4.8e-15 55.9 4.3 9e-15 55.1 0.6 2.7 3 0 0 3 3 3 1 PCI domain SNRNP27 PF08648.12 ELR13409.1 - 3.9e-20 71.7 1.9 8.7e-20 70.5 1.9 1.6 1 0 0 1 1 1 1 U4/U6.U5 small nuclear ribonucleoproteins Plus-3 PF03126.18 ELR13410.1 - 8.7e-10 39.1 0.0 1.9e-09 38.0 0.0 1.6 1 0 0 1 1 1 1 Plus-3 domain S1 PF00575.23 ELR13410.1 - 2.4e-06 27.8 0.1 0.0051 17.1 0.1 2.6 2 0 0 2 2 2 2 S1 RNA binding domain Peptidase_C1 PF00112.23 ELR13411.1 - 3.4e-19 69.8 0.1 3.5e-19 69.7 0.1 1.0 1 0 0 1 1 1 1 Papain family cysteine protease Peptidase_C1_2 PF03051.15 ELR13411.1 - 0.054 12.3 0.0 0.063 12.0 0.0 1.0 1 0 0 1 1 1 0 Peptidase C1-like family Peptidase_C1 PF00112.23 ELR13413.1 - 4e-65 220.0 5.7 5.6e-65 219.5 5.7 1.2 1 0 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.12 ELR13413.1 - 1e-13 51.5 0.9 1.6e-13 50.8 0.9 1.3 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Peptidase_C1_2 PF03051.15 ELR13413.1 - 0.0013 17.6 0.4 0.81 8.4 0.0 2.2 2 0 0 2 2 2 2 Peptidase C1-like family PBP1_TM PF14812.6 ELR13414.1 - 0.038 14.3 11.6 0.057 13.8 11.6 1.2 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal FAM176 PF14851.6 ELR13414.1 - 0.07 12.8 2.4 0.092 12.4 2.4 1.2 1 0 0 1 1 1 0 FAM176 family Sporozoite_P67 PF05642.11 ELR13414.1 - 0.085 10.9 5.0 0.1 10.6 5.0 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen NOA36 PF06524.12 ELR13414.1 - 0.13 11.6 12.1 0.17 11.1 12.1 1.1 1 0 0 1 1 1 0 NOA36 protein Menin PF05053.13 ELR13414.1 - 0.36 9.1 3.0 0.49 8.7 3.0 1.1 1 0 0 1 1 1 0 Menin DUF2457 PF10446.9 ELR13414.1 - 0.39 9.8 17.8 0.48 9.5 17.8 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) RXT2_N PF08595.11 ELR13414.1 - 0.82 9.7 6.7 1.3 9.1 6.7 1.2 1 0 0 1 1 1 0 RXT2-like, N-terminal CENP-B_dimeris PF09026.10 ELR13414.1 - 1.2 9.5 14.8 1.9 8.9 14.8 1.3 1 0 0 1 1 1 0 Centromere protein B dimerisation domain CDC45 PF02724.14 ELR13414.1 - 1.9 6.7 10.4 2.3 6.4 10.4 1.0 1 0 0 1 1 1 0 CDC45-like protein DUF4611 PF15387.6 ELR13414.1 - 3.2 8.0 10.4 5.7 7.2 10.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4611) DNA_pol_phi PF04931.13 ELR13414.1 - 4.2 5.3 12.6 5.1 5.1 12.6 1.1 1 0 0 1 1 1 0 DNA polymerase phi CobT PF06213.12 ELR13414.1 - 8.2 5.7 11.1 10 5.4 11.1 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Pkinase PF00069.25 ELR13415.1 - 7.5e-06 25.5 0.0 1e-05 25.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Cellulase PF00150.18 ELR13416.1 - 5.7e-46 157.2 0.1 7.3e-46 156.8 0.1 1.1 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) Glyco_hydro_53 PF07745.13 ELR13416.1 - 0.081 11.9 0.0 0.13 11.2 0.0 1.3 1 0 0 1 1 1 0 Glycosyl hydrolase family 53 Pkinase_Tyr PF07714.17 ELR13417.1 - 1.8e-14 53.7 0.0 6.6e-07 28.9 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 ELR13417.1 - 2e-12 47.0 0.0 4.9e-11 42.5 0.0 2.0 1 1 0 1 1 1 1 Protein kinase domain CitMHS PF03600.16 ELR13418.1 - 2e-53 181.6 1.0 2e-53 181.6 1.0 1.8 1 1 1 2 2 2 1 Citrate transporter Na_sulph_symp PF00939.19 ELR13418.1 - 2.1e-05 23.8 31.2 4.2e-05 22.8 17.5 3.1 2 2 0 2 2 2 2 Sodium:sulfate symporter transmembrane region zf-U1 PF06220.12 ELR13422.1 - 3.1 7.6 15.7 0.12 12.1 3.0 2.8 2 1 1 3 3 3 0 U1 zinc finger Na_Ca_ex PF01699.24 ELR13423.1 - 2.1e-08 34.3 9.1 2.3e-05 24.4 1.5 2.5 3 0 0 3 3 3 2 Sodium/calcium exchanger protein Oxysterol_BP PF01237.18 ELR13423.1 - 0.00051 19.0 0.0 0.00072 18.5 0.0 1.2 1 0 0 1 1 1 1 Oxysterol-binding protein YccF PF03733.13 ELR13424.1 - 7e-21 74.7 27.8 7.5e-19 68.2 11.0 4.4 4 1 1 5 5 5 2 Inner membrane component domain Na_Ca_ex PF01699.24 ELR13424.1 - 1.8e-09 37.7 20.5 6.6e-07 29.4 11.2 3.9 4 0 0 4 4 4 2 Sodium/calcium exchanger protein Oxysterol_BP PF01237.18 ELR13425.1 - 1.1e-54 185.7 1.2 3e-53 181.0 1.2 2.6 1 1 0 1 1 1 1 Oxysterol-binding protein CitMHS PF03600.16 ELR13426.1 - 1.6e-50 172.0 24.8 1.6e-50 172.0 24.8 1.8 1 1 1 2 2 2 1 Citrate transporter Na_sulph_symp PF00939.19 ELR13426.1 - 8.7e-06 25.0 40.3 0.00084 18.5 16.5 2.7 2 1 0 2 2 2 2 Sodium:sulfate symporter transmembrane region ArsB PF02040.15 ELR13426.1 - 1e-05 25.1 31.0 8.2e-05 22.1 8.6 2.3 2 1 0 2 2 2 2 Arsenical pump membrane protein SNF2_N PF00176.23 ELR13427.1 - 5.9e-59 199.5 1.6 9.9e-59 198.8 1.6 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain FYRC PF05965.14 ELR13427.1 - 1.2e-22 79.9 0.0 2.9e-22 78.6 0.0 1.7 1 0 0 1 1 1 1 F/Y rich C-terminus Helicase_C PF00271.31 ELR13427.1 - 3.7e-19 69.1 0.0 7.7e-19 68.1 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain FYRN PF05964.14 ELR13427.1 - 3.5e-18 65.2 0.0 6.9e-18 64.2 0.0 1.5 1 0 0 1 1 1 1 F/Y-rich N-terminus Chromo PF00385.24 ELR13427.1 - 9.5e-13 47.9 2.7 2.5e-12 46.5 1.4 2.5 2 0 0 2 2 2 1 Chromo (CHRromatin Organisation MOdifier) domain CHDCT2 PF08074.11 ELR13427.1 - 9.8e-10 38.9 1.8 0.0025 18.0 0.1 3.8 3 0 0 3 3 3 2 CHDCT2 (NUC038) domain ResIII PF04851.15 ELR13427.1 - 3.5e-09 36.9 0.0 1.1e-08 35.3 0.0 1.9 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Myb_DNA-binding PF00249.31 ELR13427.1 - 5.4e-08 32.9 4.5 0.15 12.2 0.1 4.9 4 0 0 4 4 4 2 Myb-like DNA-binding domain HDA2-3 PF11496.8 ELR13427.1 - 3.2e-06 26.5 0.0 3.2e-06 26.5 0.0 2.0 2 1 0 2 2 1 1 Class II histone deacetylase complex subunits 2 and 3 SLIDE PF09111.10 ELR13427.1 - 0.00022 21.2 0.1 0.058 13.4 0.0 3.3 3 0 0 3 3 3 1 SLIDE DEAD PF00270.29 ELR13427.1 - 0.0016 18.3 0.0 0.0034 17.2 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Myb_DNA-bind_7 PF15963.5 ELR13427.1 - 0.033 14.1 0.3 0.56 10.1 0.0 2.8 2 0 0 2 2 2 0 Myb DNA-binding like MFMR_assoc PF16596.5 ELR13428.1 - 0.11 12.9 15.7 0.22 12.0 15.7 1.5 1 1 0 1 1 1 0 Disordered region downstream of MFMR AF-4 PF05110.13 ELR13428.1 - 0.12 10.5 12.1 0.12 10.4 12.1 1.0 1 0 0 1 1 1 0 AF-4 proto-oncoprotein Nop14 PF04147.12 ELR13428.1 - 2.1 6.5 11.0 2.6 6.2 11.0 1.1 1 0 0 1 1 1 0 Nop14-like family TIMELESS_C PF05029.13 ELR13428.1 - 3.1 6.8 11.8 3.8 6.5 11.8 1.1 1 0 0 1 1 1 0 Timeless protein C terminal region ADH_N PF08240.12 ELR13429.1 - 3.2e-32 110.6 0.4 3.2e-32 110.6 0.4 1.8 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 ELR13429.1 - 1.7e-09 37.7 0.2 3.9e-09 36.6 0.2 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase WRKY PF03106.15 ELR13429.1 - 0.00059 20.0 1.5 0.0012 19.0 1.5 1.5 1 0 0 1 1 1 1 WRKY DNA -binding domain FLYWCH PF04500.16 ELR13429.1 - 0.015 15.4 0.1 0.04 14.0 0.1 1.7 1 0 0 1 1 1 0 FLYWCH zinc finger domain TBCA PF02970.16 ELR13429.1 - 0.89 9.9 5.7 1.7 9.1 5.7 1.4 1 0 0 1 1 1 0 Tubulin binding cofactor A Usp PF00582.26 ELR13430.1 - 5.5e-13 49.6 0.0 1.1e-12 48.6 0.0 1.5 1 1 0 1 1 1 1 Universal stress protein family PseudoU_synth_1 PF01416.20 ELR13431.1 - 3.1e-09 37.2 0.1 1.7e-05 25.2 0.0 3.3 2 2 0 2 2 2 1 tRNA pseudouridine synthase DUF4551 PF15087.6 ELR13431.1 - 0.2 10.4 0.0 0.23 10.3 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) DEAD PF00270.29 ELR13432.1 - 1.6e-29 102.9 0.0 2.6e-21 76.2 0.0 2.6 2 0 0 2 2 2 2 DEAD/DEAH box helicase Helicase_C PF00271.31 ELR13432.1 - 2.9e-25 88.7 0.0 9.5e-25 87.1 0.0 2.0 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 ELR13432.1 - 0.011 15.7 0.1 0.076 13.0 0.0 2.3 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit HSP20 PF00011.21 ELR13434.1 - 4.3e-12 46.1 0.0 6.6e-12 45.5 0.0 1.2 1 0 0 1 1 1 1 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 ELR13434.1 - 1.6e-05 24.4 0.1 2.5e-05 23.8 0.1 1.3 1 0 0 1 1 1 1 HSP20-like domain found in ArsA EF-hand_1 PF00036.32 ELR13435.1 - 2.3e-05 23.6 0.0 5.8e-05 22.4 0.0 1.8 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.6 ELR13435.1 - 0.0002 21.0 0.0 0.00079 19.2 0.0 2.0 1 0 0 1 1 1 1 EF-hand domain EF-hand_5 PF13202.6 ELR13435.1 - 0.0016 17.8 0.1 0.0043 16.5 0.1 1.7 1 0 0 1 1 1 1 EF hand EF-hand_7 PF13499.6 ELR13435.1 - 0.004 17.6 0.0 0.014 15.9 0.0 1.8 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.6 ELR13435.1 - 0.011 15.6 0.0 0.025 14.4 0.0 1.6 1 0 0 1 1 1 0 EF-hand domain pair zf-HC2 PF13490.6 ELR13435.1 - 0.11 12.7 1.1 0.36 11.1 1.1 2.0 1 0 0 1 1 1 0 Putative zinc-finger S4 PF01479.25 ELR13436.1 - 0.097 12.4 0.0 3 7.6 0.0 2.7 2 0 0 2 2 2 0 S4 domain DNA_pol_B_palm PF14792.6 ELR13437.1 - 1.8e-35 121.6 0.5 3.6e-35 120.6 0.5 1.5 1 0 0 1 1 1 1 DNA polymerase beta palm DNA_pol_B_thumb PF14791.6 ELR13437.1 - 3.7e-21 75.1 0.3 1.2e-19 70.2 0.0 2.4 2 0 0 2 2 2 1 DNA polymerase beta thumb HHH_8 PF14716.6 ELR13437.1 - 2.3e-18 66.3 0.8 5.5e-18 65.1 0.8 1.7 1 0 0 1 1 1 1 Helix-hairpin-helix domain DNA_pol_lambd_f PF10391.9 ELR13437.1 - 0.0002 21.1 0.1 0.00049 19.9 0.1 1.8 1 0 0 1 1 1 1 Fingers domain of DNA polymerase lambda fn3_5 PF06280.12 ELR13437.1 - 0.12 13.0 0.3 0.65 10.7 0.0 2.3 4 0 0 4 4 4 0 Fn3-like domain CK2S PF15011.6 ELR13437.1 - 0.14 12.0 1.0 0.3 10.9 0.2 1.8 2 0 0 2 2 2 0 Casein Kinase 2 substrate MCRS_N PF13325.6 ELR13437.1 - 0.19 11.7 3.0 0.31 11.0 2.5 1.6 1 1 0 1 1 1 0 N-terminal region of micro-spherule protein NTP_transf_2 PF01909.23 ELR13437.1 - 0.42 10.9 4.7 2.1 8.7 4.7 2.3 1 1 0 1 1 1 0 Nucleotidyltransferase domain FAM176 PF14851.6 ELR13437.1 - 0.63 9.7 3.7 1.9 8.1 1.6 2.2 2 0 0 2 2 2 0 FAM176 family Ribosomal_60s PF00428.19 ELR13437.1 - 1.9 9.1 9.9 0.73 10.5 5.8 2.3 3 0 0 3 3 2 0 60s Acidic ribosomal protein RasGAP PF00616.19 ELR13437.1 - 9.1 5.9 7.9 7.8 6.1 0.2 2.2 2 0 0 2 2 2 0 GTPase-activator protein for Ras-like GTPase Thioredoxin PF00085.20 ELR13438.1 - 2.6e-29 101.2 0.1 1e-28 99.4 0.0 1.9 2 0 0 2 2 2 1 Thioredoxin Thioredoxin_2 PF13098.6 ELR13438.1 - 3.5e-05 24.2 0.2 0.001 19.5 0.2 2.3 1 1 0 1 1 1 1 Thioredoxin-like domain TraF PF13728.6 ELR13438.1 - 5.6e-05 23.1 0.0 6.9e-05 22.8 0.0 1.2 1 0 0 1 1 1 1 F plasmid transfer operon protein OST3_OST6 PF04756.13 ELR13438.1 - 0.00012 21.6 0.0 0.00025 20.5 0.0 1.7 1 1 0 1 1 1 1 OST3 / OST6 family, transporter family Thioredoxin_9 PF14595.6 ELR13438.1 - 0.053 13.3 0.0 0.086 12.6 0.0 1.3 1 0 0 1 1 1 0 Thioredoxin TrbC_Ftype PF09673.10 ELR13438.1 - 0.097 12.7 0.0 0.2 11.7 0.0 1.5 1 0 0 1 1 1 0 Type-F conjugative transfer system pilin assembly protein Thioredoxin_3 PF13192.6 ELR13438.1 - 0.13 12.3 0.0 0.26 11.4 0.0 1.5 1 0 0 1 1 1 0 Thioredoxin domain Thioredoxin_8 PF13905.6 ELR13438.1 - 0.13 12.6 0.0 4.5 7.7 0.0 2.4 1 1 1 2 2 2 0 Thioredoxin-like Thioredoxin_6 PF13848.6 ELR13438.1 - 0.19 11.7 0.0 0.4 10.6 0.0 1.5 2 0 0 2 2 2 0 Thioredoxin-like domain RVT_1 PF00078.27 ELR13440.1 - 6.9e-05 22.5 0.9 0.00017 21.2 0.3 1.9 1 1 1 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) Phage_integrase PF00589.22 ELR13442.1 - 9.8e-05 22.2 0.0 0.00019 21.3 0.0 1.6 1 1 0 1 1 1 1 Phage integrase family Prenyltrans PF00432.21 ELR13445.1 - 1.6e-49 165.3 7.2 8.3e-11 41.4 0.0 5.4 5 0 0 5 5 5 5 Prenyltransferase and squalene oxidase repeat SQHop_cyclase_C PF13243.6 ELR13445.1 - 0.0028 16.8 0.0 0.16 11.0 0.0 2.8 1 1 2 3 3 3 2 Squalene-hopene cyclase C-terminal domain SQHop_cyclase_N PF13249.6 ELR13445.1 - 0.061 12.4 0.0 9.4 5.2 0.0 2.8 2 1 1 3 3 3 0 Squalene-hopene cyclase N-terminal domain Aminotran_4 PF01063.19 ELR13446.1 - 3e-27 95.9 0.0 5.6e-27 95.0 0.0 1.4 2 0 0 2 2 2 1 Amino-transferase class IV Rad60-SLD PF11976.8 ELR13447.1 - 2.2e-12 46.6 0.0 2.9e-12 46.3 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.23 ELR13447.1 - 1.9e-05 24.3 0.0 2.6e-05 23.9 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin family YukD PF08817.10 ELR13447.1 - 0.0064 17.2 0.1 0.0096 16.6 0.1 1.3 1 1 0 1 1 1 1 WXG100 protein secretion system (Wss), protein YukD AAA_2 PF07724.14 ELR13448.1 - 3e-33 115.4 0.1 8e-33 114.0 0.0 1.7 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA PF00004.29 ELR13448.1 - 9.9e-07 29.3 0.0 2.2e-06 28.1 0.0 1.6 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) ClpB_D2-small PF10431.9 ELR13448.1 - 9.5e-06 25.6 0.6 2.9e-05 24.1 0.6 2.0 1 1 0 1 1 1 1 C-terminal, D2-small domain, of ClpB protein DUF2120 PF09893.9 ELR13448.1 - 0.062 13.4 0.5 8.6 6.5 0.0 2.2 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2120) RasGAP PF00616.19 ELR13450.1 - 2.5e-12 47.0 0.3 8.2e-09 35.5 0.1 2.7 2 1 1 3 3 3 2 GTPase-activator protein for Ras-like GTPase DUF2894 PF11445.8 ELR13450.1 - 0.17 12.3 3.9 0.84 10.1 1.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2894) Abhydrolase_3 PF07859.13 ELR13452.1 - 5.7e-53 179.9 0.0 7.3e-53 179.5 0.0 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold Say1_Mug180 PF10340.9 ELR13452.1 - 5.3e-16 58.5 0.0 7.1e-16 58.0 0.0 1.2 1 0 0 1 1 1 1 Steryl acetyl hydrolase Peptidase_S9 PF00326.21 ELR13452.1 - 0.00011 21.7 0.0 0.00022 20.8 0.0 1.5 1 0 0 1 1 1 1 Prolyl oligopeptidase family COesterase PF00135.28 ELR13452.1 - 0.024 13.5 0.0 0.66 8.8 0.0 2.0 2 0 0 2 2 2 0 Carboxylesterase family zf-UBR PF02207.20 ELR13453.1 - 5e-20 71.4 9.5 8.2e-20 70.8 9.5 1.3 1 0 0 1 1 1 1 Putative zinc finger in N-recognin (UBR box) SUR7 PF06687.12 ELR13454.1 - 0.00016 21.4 3.6 0.00016 21.4 3.6 3.0 2 1 1 3 3 3 1 SUR7/PalI family DUF2721 PF11026.8 ELR13454.1 - 0.0037 17.2 0.2 0.0037 17.2 0.2 2.8 3 0 0 3 3 3 1 Protein of unknown function (DUF2721) Prominin PF05478.11 ELR13454.1 - 0.01 13.8 2.0 0.049 11.6 1.1 2.2 2 1 0 2 2 2 0 Prominin Tweety PF04906.13 ELR13454.1 - 0.021 13.5 8.4 0.052 12.2 1.0 2.6 2 1 1 3 3 3 0 Tweety ApoO PF09769.9 ELR13454.1 - 0.14 12.1 0.1 0.32 10.9 0.1 1.6 1 1 0 1 1 1 0 Apolipoprotein O Tetraspanin PF00335.20 ELR13454.1 - 3.4 7.3 11.0 60 3.2 5.8 3.1 2 1 1 3 3 3 0 Tetraspanin family 4F5 PF04419.14 ELR13455.1 - 1.9e-07 31.8 12.1 1.9e-07 31.8 12.1 2.9 3 0 0 3 3 3 1 4F5 protein family CtaG_Cox11 PF04442.14 ELR13456.1 - 6.8e-54 182.0 0.0 9.8e-54 181.5 0.0 1.2 1 0 0 1 1 1 1 Cytochrome c oxidase assembly protein CtaG/Cox11 2OG-FeII_Oxy_2 PF13532.6 ELR13458.1 - 4.5e-29 102.0 0.1 1.9e-27 96.8 0.1 2.0 1 1 1 2 2 2 2 2OG-Fe(II) oxygenase superfamily SAM_1 PF00536.30 ELR13459.1 - 5e-39 132.6 1.2 1.7e-17 63.6 0.0 3.3 3 0 0 3 3 3 3 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 ELR13459.1 - 4.5e-35 119.6 0.8 5.1e-16 58.5 0.0 3.4 3 0 0 3 3 3 3 SAM domain (Sterile alpha motif) RasGAP PF00616.19 ELR13459.1 - 2.2e-15 56.9 0.0 1e-12 48.2 0.0 2.2 1 1 1 2 2 2 2 GTPase-activator protein for Ras-like GTPase SAM_3 PF18016.1 ELR13459.1 - 1.9e-10 40.4 0.3 0.023 14.5 0.0 3.6 3 0 0 3 3 3 3 SAM domain (Sterile alpha motif) DNA_meth_N PF18284.1 ELR13459.1 - 0.015 15.2 0.3 10 6.1 0.0 2.9 2 0 0 2 2 2 0 DNA methylase N-terminal domain zf-UBR PF02207.20 ELR13461.1 - 1.6e-19 69.8 9.5 2.7e-19 69.1 9.5 1.4 1 0 0 1 1 1 1 Putative zinc finger in N-recognin (UBR box) RasGAP PF00616.19 ELR13461.1 - 1.9e-13 50.6 0.0 3.8e-13 49.6 0.0 1.4 1 1 0 1 1 1 1 GTPase-activator protein for Ras-like GTPase zf-B_box PF00643.24 ELR13461.1 - 0.018 15.2 3.9 0.048 13.8 3.9 1.7 1 0 0 1 1 1 0 B-box zinc finger CBM49 PF09478.10 ELR13462.1 - 5.7e-20 71.4 0.4 4e-08 33.5 0.0 3.2 3 0 0 3 3 3 3 Carbohydrate binding domain CBM49 CBM_2 PF00553.19 ELR13462.1 - 1.3e-05 25.4 15.1 0.0012 19.1 1.6 3.6 3 1 0 3 3 3 3 Cellulose binding domain DUF11 PF01345.18 ELR13462.1 - 0.058 13.7 1.8 3.4 8.0 0.1 3.2 2 1 1 3 3 3 0 Domain of unknown function DUF11 Pyocin_S PF06958.12 ELR13462.1 - 1.1 9.8 5.1 3.4 8.2 0.7 2.5 2 0 0 2 2 2 0 S-type Pyocin PAC2 PF09754.9 ELR13463.1 - 2.9e-20 73.2 0.1 6.1e-20 72.2 0.1 1.5 1 1 0 1 1 1 1 PAC2 family CDC45 PF02724.14 ELR13463.1 - 0.026 12.9 22.5 0.033 12.5 22.5 1.1 1 0 0 1 1 1 0 CDC45-like protein MCM_bind PF09739.9 ELR13463.1 - 0.047 12.1 5.5 0.063 11.7 5.5 1.3 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor Velvet PF11754.8 ELR13463.1 - 0.064 13.2 2.2 0.089 12.7 2.2 1.3 1 0 0 1 1 1 0 Velvet factor Neur_chan_memb PF02932.16 ELR13463.1 - 0.23 11.5 4.2 0.36 10.8 4.2 1.4 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF4407 PF14362.6 ELR13463.1 - 0.38 10.1 9.2 0.69 9.2 9.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF4614 PF15391.6 ELR13463.1 - 1.1 9.2 7.9 1.9 8.4 7.9 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4614) Hid1 PF12722.7 ELR13463.1 - 1.2 7.2 13.2 1.5 6.8 13.2 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Apt1 PF10351.9 ELR13463.1 - 1.2 7.9 13.7 1.7 7.4 13.7 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain Dsh_C PF12316.8 ELR13463.1 - 3.3 8.1 11.3 5.7 7.3 11.3 1.4 1 0 0 1 1 1 0 Segment polarity protein dishevelled (Dsh) C terminal Presenilin PF01080.17 ELR13463.1 - 5.2 5.7 22.8 8.1 5.1 22.8 1.2 1 0 0 1 1 1 0 Presenilin DUF3827 PF12877.7 ELR13463.1 - 8.5 4.6 12.4 11 4.2 12.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3827) PRCC PF10253.9 ELR13464.1 - 1.2e-15 58.9 19.3 1.2e-15 58.9 19.3 2.1 1 1 1 2 2 2 1 Mitotic checkpoint regulator, MAD2B-interacting Linker_histone PF00538.19 ELR13465.1 - 3.3e-16 59.4 0.0 9.7e-16 57.9 0.0 1.9 1 0 0 1 1 1 1 linker histone H1 and H5 family WWE PF02825.20 ELR13465.1 - 1.2e-11 45.0 1.4 9.3e-11 42.2 1.8 2.3 2 0 0 2 2 2 1 WWE domain GREB1 PF15782.5 ELR13465.1 - 0.085 10.0 19.1 0.1 9.7 19.1 1.2 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer HemN_C PF06969.16 ELR13465.1 - 0.21 11.6 0.0 0.45 10.6 0.0 1.5 1 1 0 1 1 1 0 HemN C-terminal domain SOG2 PF10428.9 ELR13465.1 - 0.57 9.3 31.2 0.73 9.0 31.2 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein PNISR PF15996.5 ELR13465.1 - 0.64 10.3 22.3 0.099 12.9 15.2 2.1 2 0 0 2 2 2 0 Arginine/serine-rich protein PNISR Macoilin PF09726.9 ELR13465.1 - 0.78 8.2 49.7 0.0055 15.3 21.5 2.1 1 1 1 2 2 2 0 Macoilin family MAP70 PF07058.11 ELR13465.1 - 1.3 7.6 20.9 2.2 7.0 20.9 1.3 1 0 0 1 1 1 0 Microtubule-associated protein 70 SOBP PF15279.6 ELR13465.1 - 2.8 8.5 28.0 0.6 10.7 21.0 2.1 2 0 0 2 2 2 0 Sine oculis-binding protein Pribosyltran PF00156.27 ELR13466.1 - 1.3e-10 41.1 0.0 1.8e-10 40.6 0.0 1.2 1 0 0 1 1 1 1 Phosphoribosyl transferase domain PRTase_2 PF15609.6 ELR13466.1 - 0.00049 19.7 0.0 0.00057 19.4 0.0 1.1 1 0 0 1 1 1 1 Phosphoribosyl transferase UPRTase PF14681.6 ELR13466.1 - 0.011 15.1 0.0 0.016 14.7 0.0 1.2 1 0 0 1 1 1 0 Uracil phosphoribosyltransferase Pkinase PF00069.25 ELR13467.1 - 2.5e-56 191.0 0.0 1.2e-54 185.4 0.0 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR13467.1 - 2e-29 102.7 0.0 1.5e-18 67.1 0.0 2.0 1 1 1 2 2 2 2 Protein tyrosine kinase Haspin_kinase PF12330.8 ELR13467.1 - 0.00028 20.0 0.5 0.00045 19.3 0.3 1.4 1 1 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 ELR13467.1 - 0.00065 19.1 0.1 0.00089 18.7 0.1 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 ELR13467.1 - 0.005 16.2 0.0 0.0068 15.8 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Choline_kinase PF01633.20 ELR13467.1 - 0.046 13.3 1.6 0.11 12.0 1.6 1.7 1 1 0 1 1 1 0 Choline/ethanolamine kinase APH PF01636.23 ELR13467.1 - 0.13 12.2 0.2 1.2 9.0 0.1 2.0 2 0 0 2 2 2 0 Phosphotransferase enzyme family DUF676 PF05057.14 ELR13469.1 - 2e-05 24.3 0.0 3.8e-05 23.3 0.1 1.5 2 0 0 2 2 2 1 Putative serine esterase (DUF676) Abhydrolase_3 PF07859.13 ELR13470.1 - 4e-38 131.4 0.0 4.9e-38 131.1 0.0 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold Say1_Mug180 PF10340.9 ELR13470.1 - 4.3e-10 39.0 0.0 6.1e-10 38.5 0.0 1.2 1 1 0 1 1 1 1 Steryl acetyl hydrolase Peptidase_S9 PF00326.21 ELR13470.1 - 0.0013 18.2 0.0 0.0018 17.8 0.0 1.3 1 1 0 1 1 1 1 Prolyl oligopeptidase family LEA_3 PF03242.13 ELR13470.1 - 0.17 12.6 0.0 0.28 11.9 0.0 1.3 1 0 0 1 1 1 0 Late embryogenesis abundant protein Abhydrolase_2 PF02230.16 ELR13470.1 - 0.25 11.1 0.0 0.32 10.8 0.0 1.1 1 0 0 1 1 1 0 Phospholipase/Carboxylesterase BBS2_Mid PF14783.6 ELR13471.1 - 0.095 12.8 0.0 2.9 7.9 0.0 2.3 2 0 0 2 2 2 0 Ciliary BBSome complex subunit 2, middle region CBS PF00571.28 ELR13472.1 - 1.2e-27 96.2 0.5 3.3e-13 49.9 0.1 2.3 2 0 0 2 2 2 2 CBS domain GST_C_3 PF14497.6 ELR13473.1 - 1.4e-14 54.1 0.0 1.8e-14 53.7 0.0 1.1 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 ELR13473.1 - 1.9e-06 28.0 0.0 2.3e-06 27.7 0.0 1.1 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 ELR13473.1 - 0.0012 18.8 0.0 0.0016 18.4 0.0 1.4 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain BCS1_N PF08740.11 ELR13474.1 - 2.7e-06 27.5 0.3 3.3e-06 27.2 0.3 1.0 1 0 0 1 1 1 1 BCS1 N terminal AAA PF00004.29 ELR13475.1 - 4.5e-18 66.0 0.0 1.3e-17 64.4 0.0 1.8 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DUF815 PF05673.13 ELR13475.1 - 0.00053 19.2 0.0 0.0016 17.7 0.0 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF815) RNA_helicase PF00910.22 ELR13475.1 - 0.0016 18.8 0.0 0.0058 17.0 0.0 2.0 1 1 0 1 1 1 1 RNA helicase AAA_5 PF07728.14 ELR13475.1 - 0.004 17.2 0.0 0.14 12.2 0.0 2.6 1 1 1 2 2 2 1 AAA domain (dynein-related subfamily) AAA_33 PF13671.6 ELR13475.1 - 0.0046 17.1 0.2 0.015 15.5 0.2 2.1 1 1 0 1 1 1 1 AAA domain ATPase PF06745.13 ELR13475.1 - 0.0076 15.6 0.0 0.02 14.3 0.0 1.7 1 0 0 1 1 1 1 KaiC RuvB_N PF05496.12 ELR13475.1 - 0.013 15.3 0.0 0.026 14.3 0.0 1.5 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain ABC_tran PF00005.27 ELR13475.1 - 0.023 15.2 1.1 0.08 13.5 0.0 2.1 2 0 0 2 2 2 0 ABC transporter AAA_16 PF13191.6 ELR13475.1 - 0.03 14.7 3.6 0.15 12.4 3.6 2.6 1 1 0 1 1 1 0 AAA ATPase domain NACHT PF05729.12 ELR13475.1 - 0.033 14.1 0.3 0.58 10.1 0.0 2.7 2 1 1 3 3 3 0 NACHT domain AAA_25 PF13481.6 ELR13475.1 - 0.044 13.4 0.2 0.1 12.2 0.0 1.8 2 0 0 2 2 2 0 AAA domain Sigma54_activ_2 PF14532.6 ELR13475.1 - 0.045 13.9 0.0 0.089 12.9 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_24 PF13479.6 ELR13475.1 - 0.059 13.1 1.8 0.13 12.0 0.0 2.4 3 1 0 3 3 3 0 AAA domain IstB_IS21 PF01695.17 ELR13475.1 - 0.12 12.1 0.1 0.43 10.3 0.1 2.0 1 1 0 1 1 1 0 IstB-like ATP binding protein AAA_22 PF13401.6 ELR13475.1 - 0.13 12.6 0.2 0.29 11.4 0.2 2.0 1 1 0 1 1 1 0 AAA domain AAA_18 PF13238.6 ELR13475.1 - 0.2 12.2 0.0 0.2 12.2 0.0 2.7 2 2 0 2 2 2 0 AAA domain V_ATPase_I PF01496.19 ELR13475.1 - 2.3 6.0 5.9 3 5.6 5.9 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Presenilin PF01080.17 ELR13475.1 - 5.4 5.7 5.1 7.8 5.1 5.1 1.2 1 0 0 1 1 1 0 Presenilin FAM176 PF14851.6 ELR13475.1 - 7.4 6.2 11.7 41 3.8 9.3 2.1 2 0 0 2 2 2 0 FAM176 family CBS PF00571.28 ELR13476.1 - 1.9e-28 98.7 0.1 3.6e-14 52.9 0.0 2.1 2 0 0 2 2 2 2 CBS domain RNA_pol_Rpb2_2 PF04561.14 ELR13476.1 - 0.0079 15.8 0.1 0.0082 15.8 0.1 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 2 Ank_2 PF12796.7 ELR13477.1 - 6e-49 164.6 19.9 2.3e-16 60.2 1.6 4.9 1 1 4 5 5 5 5 Ankyrin repeats (3 copies) Ank PF00023.30 ELR13477.1 - 3.1e-47 157.0 16.8 8.1e-07 29.2 0.1 9.0 9 0 0 9 9 9 8 Ankyrin repeat Ank_4 PF13637.6 ELR13477.1 - 9.1e-42 140.9 9.5 6.3e-13 49.0 0.2 7.0 5 2 2 7 7 7 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 ELR13477.1 - 2e-38 126.0 9.5 1.9e-05 24.7 0.1 9.3 9 0 0 9 9 9 7 Ankyrin repeat Ank_5 PF13857.6 ELR13477.1 - 9.9e-36 121.3 17.1 7e-10 39.0 0.5 6.9 3 1 4 7 7 7 7 Ankyrin repeats (many copies) SSP160 PF06933.11 ELR13477.1 - 1.2 7.2 5.8 1.9 6.6 5.8 1.2 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 CBM49 PF09478.10 ELR13478.1 - 1.6e-09 38.0 0.2 7.8e-05 22.9 0.0 2.2 2 0 0 2 2 2 2 Carbohydrate binding domain CBM49 CBM_2 PF00553.19 ELR13478.1 - 2.6e-06 27.7 8.4 0.00093 19.5 2.4 2.4 2 1 0 2 2 2 2 Cellulose binding domain DUF4354 PF14263.6 ELR13478.1 - 0.0078 16.0 0.0 1.1 9.0 0.0 2.2 2 0 0 2 2 2 2 Domain of unknown function (DUF4354) DUF11 PF01345.18 ELR13478.1 - 1.4 9.3 6.2 1.6 9.1 0.2 2.7 2 1 0 2 2 2 0 Domain of unknown function DUF11 PhyH PF05721.13 ELR13480.1 - 5.4e-19 69.3 0.6 5.9e-16 59.4 0.6 2.2 1 1 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) DUF1479 PF07350.12 ELR13480.1 - 2.9e-05 23.0 0.1 0.0072 15.1 0.1 2.1 2 0 0 2 2 2 2 Protein of unknown function (DUF1479) 2OG-FeII_Oxy_5 PF13759.6 ELR13480.1 - 0.00029 21.2 0.2 0.0012 19.2 0.0 2.1 2 0 0 2 2 2 1 Putative 2OG-Fe(II) oxygenase 2OG-FeII_Oxy_3 PF13640.6 ELR13480.1 - 0.12 13.3 0.1 0.3 12.0 0.1 1.8 1 1 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily GATA PF00320.27 ELR13481.1 - 7.1e-13 47.9 4.6 1.4e-12 47.0 4.6 1.5 1 0 0 1 1 1 1 GATA zinc finger Zn-ribbon_8 PF09723.10 ELR13481.1 - 0.042 14.0 0.9 0.11 12.7 0.9 1.7 1 0 0 1 1 1 0 Zinc ribbon domain OrfB_Zn_ribbon PF07282.11 ELR13481.1 - 0.063 13.2 1.5 0.12 12.3 1.5 1.4 1 0 0 1 1 1 0 Putative transposase DNA-binding domain DZR PF12773.7 ELR13481.1 - 0.1 12.6 1.7 0.28 11.2 1.7 1.8 1 1 0 1 1 1 0 Double zinc ribbon zf-NADH-PPase PF09297.11 ELR13481.1 - 0.29 10.8 4.7 0.52 10.0 0.6 2.5 2 0 0 2 2 2 0 NADH pyrophosphatase zinc ribbon domain ADK_lid PF05191.14 ELR13481.1 - 0.47 10.5 2.3 5.5 7.1 0.1 2.4 2 0 0 2 2 2 0 Adenylate kinase, active site lid SelP_N PF04592.14 ELR13481.1 - 2.7 7.4 10.4 4.1 6.7 10.4 1.2 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Zn_ribbon_recom PF13408.6 ELR13481.1 - 4.3 7.9 8.9 16 6.1 0.5 2.5 1 1 1 2 2 2 0 Recombinase zinc beta ribbon domain RhoGEF PF00621.20 ELR13482.1 - 9.9e-71 237.7 8.3 6.5e-49 166.6 2.4 2.6 3 0 0 3 3 3 2 RhoGEF domain Hamartin PF04388.12 ELR13482.1 - 3.5e-05 22.7 17.8 0.028 13.1 1.9 3.2 3 0 0 3 3 3 3 Hamartin protein Ras PF00071.22 ELR13482.1 - 0.043 13.4 2.9 0.054 13.1 0.0 2.5 2 0 0 2 2 2 0 Ras family Pullulanase_Ins PF18494.1 ELR13482.1 - 0.1 13.1 0.3 37 4.9 0.0 2.8 2 0 0 2 2 2 0 Pullulanase Ins domain PH PF00169.29 ELR13482.1 - 0.74 10.4 5.8 2 8.9 0.3 3.7 2 2 0 2 2 2 0 PH domain Oxysterol_BP PF01237.18 ELR13482.1 - 5.2 5.8 9.6 0.18 10.6 2.8 1.9 2 0 0 2 2 2 0 Oxysterol-binding protein S_4TM PF18159.1 ELR13482.1 - 7.7 5.7 7.3 18 4.5 0.0 3.1 3 1 0 3 3 3 0 SMODS-associating 4TM effector domain TRIC PF05197.13 ELR13484.1 - 0.0009 18.9 1.0 0.0011 18.5 1.0 1.2 1 0 0 1 1 1 1 TRIC channel Aldo_ket_red PF00248.21 ELR13486.1 - 3.3e-78 262.9 0.0 5.3e-78 262.2 0.0 1.2 1 0 0 1 1 1 1 Aldo/keto reductase family Hist_deacetyl PF00850.19 ELR13486.1 - 1.4e-08 34.6 0.0 0.0025 17.4 0.0 2.2 1 1 1 2 2 2 2 Histone deacetylase domain DUF5114 PF17141.4 ELR13487.1 - 1.5 9.4 4.8 34 5.1 0.0 3.9 3 0 0 3 3 3 0 Domain of unknown function (DUF5114) PP2C_2 PF13672.6 ELR13488.1 - 1.9e-06 27.7 0.1 4.7e-06 26.4 0.1 1.6 1 0 0 1 1 1 1 Protein phosphatase 2C DUF4096 PF13340.6 ELR13488.1 - 0.12 12.6 0.1 2.3 8.5 0.0 2.5 2 0 0 2 2 2 0 Putative transposase of IS4/5 family (DUF4096) Maf_N PF08383.11 ELR13488.1 - 0.22 11.3 0.8 5.1 7.0 0.2 2.4 2 0 0 2 2 2 0 Maf N-terminal region SET PF00856.28 ELR13489.1 - 2.1e-16 60.8 0.0 4.8e-16 59.6 0.0 1.7 1 0 0 1 1 1 1 SET domain TPR_1 PF00515.28 ELR13489.1 - 4e-07 29.6 6.8 0.0013 18.5 0.3 3.9 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 ELR13489.1 - 9.3e-05 22.3 21.6 0.0012 18.8 2.0 4.6 5 0 0 5 5 5 2 Tetratricopeptide repeat DUF3541 PF12060.8 ELR13489.1 - 0.0066 16.2 0.0 0.011 15.4 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3541) TPR_9 PF13371.6 ELR13489.1 - 0.0069 16.5 9.3 0.0069 16.5 9.3 2.8 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_16 PF13432.6 ELR13489.1 - 0.012 16.2 9.9 0.012 16.2 9.9 4.4 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_11 PF13414.6 ELR13489.1 - 0.73 9.6 8.0 1.8 8.3 0.0 3.4 2 1 1 3 3 3 0 TPR repeat TPR_19 PF14559.6 ELR13489.1 - 0.99 10.0 8.0 1.6 9.3 4.0 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_14 PF13428.6 ELR13489.1 - 1.3 10.1 22.8 0.48 11.4 5.5 5.1 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_7 PF13176.6 ELR13489.1 - 3.3 7.9 5.8 4.2 7.6 0.1 3.8 3 0 0 3 3 3 0 Tetratricopeptide repeat Pkinase_Tyr PF07714.17 ELR13491.1 - 1.5e-72 244.0 0.0 2.1e-72 243.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ELR13491.1 - 1.1e-48 165.9 0.0 2.3e-48 164.9 0.0 1.5 2 0 0 2 2 2 1 Protein kinase domain Thioredoxin PF00085.20 ELR13491.1 - 9e-30 102.7 0.1 1.6e-29 101.9 0.1 1.4 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_9 PF14595.6 ELR13491.1 - 5.4e-07 29.4 0.0 9.9e-07 28.6 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin Kinase-like PF14531.6 ELR13491.1 - 1.4e-06 27.9 0.0 9.3e-06 25.2 0.0 2.0 2 0 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 ELR13491.1 - 4.2e-06 25.8 0.0 6.9e-06 25.1 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Thioredoxin_8 PF13905.6 ELR13491.1 - 4.4e-05 23.7 0.0 0.0002 21.6 0.0 2.2 2 0 0 2 2 2 1 Thioredoxin-like AhpC-TSA PF00578.21 ELR13491.1 - 0.00016 21.6 0.1 0.00031 20.6 0.1 1.5 1 0 0 1 1 1 1 AhpC/TSA family Thioredoxin_2 PF13098.6 ELR13491.1 - 0.00018 21.9 0.0 0.0011 19.5 0.0 2.2 1 1 0 1 1 1 1 Thioredoxin-like domain FTA2 PF13095.6 ELR13491.1 - 0.0002 21.1 0.0 0.14 11.8 0.0 2.3 2 0 0 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 OST3_OST6 PF04756.13 ELR13491.1 - 0.0012 18.2 0.1 0.0066 15.8 0.0 2.1 2 0 0 2 2 2 1 OST3 / OST6 family, transporter family Redoxin PF08534.10 ELR13491.1 - 0.0014 18.4 0.0 0.0027 17.4 0.0 1.5 1 0 0 1 1 1 1 Redoxin Kdo PF06293.14 ELR13491.1 - 0.0055 16.1 0.0 0.0094 15.3 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Thioredoxin_7 PF13899.6 ELR13491.1 - 0.012 15.8 0.0 0.025 14.8 0.0 1.5 1 0 0 1 1 1 0 Thioredoxin-like Haspin_kinase PF12330.8 ELR13491.1 - 0.018 14.0 0.0 0.044 12.7 0.0 1.6 1 0 0 1 1 1 0 Haspin like kinase domain TraF PF13728.6 ELR13491.1 - 0.02 14.7 0.0 0.036 13.9 0.0 1.3 1 0 0 1 1 1 0 F plasmid transfer operon protein DIM1 PF02966.16 ELR13491.1 - 0.045 13.5 0.0 0.079 12.7 0.0 1.4 1 0 0 1 1 1 0 Mitosis protein DIM1 APH PF01636.23 ELR13491.1 - 0.083 12.8 0.1 0.32 10.9 0.0 1.7 1 1 1 2 2 2 0 Phosphotransferase enzyme family Pkinase PF00069.25 ELR13492.1 - 1.1e-26 93.9 0.0 1.9e-26 93.0 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain DUF1771 PF08590.10 ELR13492.1 - 1.3e-09 38.3 7.2 1.3e-09 38.3 7.2 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF1771) Smr PF01713.21 ELR13492.1 - 6.6e-07 29.6 0.1 1.9e-06 28.2 0.1 1.8 1 0 0 1 1 1 1 Smr domain Pkinase_Tyr PF07714.17 ELR13492.1 - 2.3e-05 23.8 0.0 0.0001 21.7 0.0 1.9 1 1 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 ELR13492.1 - 5.7e-05 23.2 0.3 0.00023 21.1 0.0 2.0 2 0 0 2 2 2 1 Phosphotransferase enzyme family F-box_5 PF18511.1 ELR13492.1 - 0.014 15.0 0.1 0.36 10.4 0.0 2.3 2 0 0 2 2 2 0 F-box Glyco_H_20C_C PF18088.1 ELR13492.1 - 0.016 15.1 0.1 0.024 14.5 0.1 1.2 1 0 0 1 1 1 0 Glycoside Hydrolase 20C C-terminal domain Choline_kinase PF01633.20 ELR13492.1 - 0.04 13.5 0.0 0.057 13.0 0.0 1.3 1 0 0 1 1 1 0 Choline/ethanolamine kinase TPR_14 PF13428.6 ELR13492.1 - 0.71 10.8 6.0 32 5.7 0.1 3.5 3 1 0 3 3 3 0 Tetratricopeptide repeat Metallophos PF00149.28 ELR13494.1 - 1.1e-13 52.2 0.3 1.7e-13 51.5 0.3 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 ELR13494.1 - 1e-06 29.1 0.0 0.0043 17.3 0.0 2.2 2 0 0 2 2 2 2 Calcineurin-like phosphoesterase superfamily domain MutL PF13941.6 ELR13494.1 - 0.047 12.3 0.0 0.078 11.6 0.0 1.2 1 0 0 1 1 1 0 MutL protein Ras PF00071.22 ELR13495.1 - 2e-24 86.0 0.0 1.6e-15 57.0 0.0 2.0 2 0 0 2 2 2 2 Ras family Roc PF08477.13 ELR13495.1 - 3.5e-11 43.3 0.0 3.6e-06 27.2 0.0 2.2 1 1 1 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 ELR13495.1 - 5.4e-05 23.2 0.0 8.1e-05 22.7 0.0 1.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase Thioredoxin PF00085.20 ELR13496.1 - 1.8e-31 108.1 0.1 2.1e-31 108.0 0.1 1.0 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_9 PF14595.6 ELR13496.1 - 5.3e-07 29.5 0.0 6e-07 29.3 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.6 ELR13496.1 - 1.4e-06 28.7 0.0 2e-05 25.0 0.0 2.0 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_8 PF13905.6 ELR13496.1 - 2.6e-06 27.7 0.0 7.3e-06 26.2 0.0 1.7 1 1 0 1 1 1 1 Thioredoxin-like AhpC-TSA PF00578.21 ELR13496.1 - 8.5e-06 25.7 0.0 9.4e-06 25.6 0.0 1.1 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 ELR13496.1 - 9.4e-05 22.2 0.1 0.00018 21.2 0.1 1.3 1 1 0 1 1 1 1 Redoxin OST3_OST6 PF04756.13 ELR13496.1 - 0.00017 21.1 0.0 0.00019 20.9 0.0 1.1 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family TraF PF13728.6 ELR13496.1 - 0.00039 20.3 0.0 0.00043 20.2 0.0 1.1 1 0 0 1 1 1 1 F plasmid transfer operon protein Thioredoxin_7 PF13899.6 ELR13496.1 - 0.00042 20.4 0.0 0.00064 19.8 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin-like DIM1 PF02966.16 ELR13496.1 - 0.00076 19.3 0.0 0.00077 19.3 0.0 1.0 1 0 0 1 1 1 1 Mitosis protein DIM1 Thioredoxin_5 PF13743.6 ELR13496.1 - 0.038 13.7 0.1 1.3 8.7 0.0 2.1 1 1 0 2 2 2 0 Thioredoxin Glutaredoxin PF00462.24 ELR13496.1 - 0.068 13.4 0.0 0.11 12.8 0.0 1.3 1 0 0 1 1 1 0 Glutaredoxin DUF953 PF06110.11 ELR13496.1 - 0.093 12.4 0.1 0.49 10.0 0.1 2.0 1 1 0 1 1 1 0 Eukaryotic protein of unknown function (DUF953) Pkinase PF00069.25 ELR13497.1 - 1.1e-19 70.9 0.0 1.8e-19 70.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR13497.1 - 6.3e-05 22.4 0.0 9.7e-05 21.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 ELR13497.1 - 9.3e-05 22.5 0.1 0.00017 21.6 0.1 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 ELR13497.1 - 0.14 11.8 0.0 0.22 11.1 0.0 1.2 1 0 0 1 1 1 0 Choline/ethanolamine kinase KH_1 PF00013.29 ELR13498.1 - 3.3e-17 62.1 0.2 8.5e-17 60.7 0.2 1.8 1 0 0 1 1 1 1 KH domain DUF1771 PF08590.10 ELR13498.1 - 1.6e-13 50.8 12.8 1.6e-13 50.8 12.8 3.8 2 2 0 2 2 2 1 Domain of unknown function (DUF1771) Smr PF01713.21 ELR13498.1 - 1.6e-09 38.0 1.9 2.3e-09 37.5 0.1 2.3 2 1 0 2 2 2 1 Smr domain SLS PF14611.6 ELR13498.1 - 0.00017 21.5 1.5 0.00017 21.5 1.5 1.5 1 1 0 1 1 1 1 Mitochondrial inner-membrane-bound regulator Secretin_N PF03958.17 ELR13498.1 - 0.039 14.4 2.1 0.34 11.3 2.1 2.4 1 1 0 1 1 1 0 Bacterial type II/III secretion system short domain SNF2_N PF00176.23 ELR13499.1 - 3.4e-58 197.0 0.1 6.2e-58 196.2 0.1 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 ELR13499.1 - 1.4e-15 57.6 0.0 3.2e-15 56.4 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain SAP PF02037.27 ELR13499.1 - 1.5e-10 40.6 0.1 3.1e-10 39.5 0.1 1.6 1 0 0 1 1 1 1 SAP domain zf-RING_2 PF13639.6 ELR13499.1 - 2.5e-07 30.9 7.7 4.4e-07 30.1 7.7 1.4 1 0 0 1 1 1 1 Ring finger domain ResIII PF04851.15 ELR13499.1 - 5.5e-07 29.7 0.1 2.2e-06 27.8 0.0 2.1 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit zf-C3HC4 PF00097.25 ELR13499.1 - 2e-05 24.4 6.6 3.4e-05 23.6 6.6 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 ELR13499.1 - 2.4e-05 24.1 4.9 4e-05 23.4 4.9 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 ELR13499.1 - 0.0001 22.1 5.4 0.00022 21.0 5.4 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-UDP PF14569.6 ELR13499.1 - 0.00017 21.6 2.5 0.00055 20.0 2.5 1.8 1 0 0 1 1 1 1 Zinc-binding RING-finger zf-C3HC4_2 PF13923.6 ELR13499.1 - 0.00052 19.8 7.1 0.0011 18.8 7.1 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ELR13499.1 - 0.00064 19.6 6.7 0.0011 18.9 6.7 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_4 PF15227.6 ELR13499.1 - 0.0017 18.5 7.6 0.0032 17.6 7.6 1.5 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.6 ELR13499.1 - 0.0077 16.2 7.1 0.016 15.2 7.1 1.5 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_4 PF14570.6 ELR13499.1 - 0.01 15.6 7.6 0.022 14.5 7.6 1.6 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-ANAPC11 PF12861.7 ELR13499.1 - 0.02 14.9 1.7 0.048 13.7 1.7 1.6 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-rbx1 PF12678.7 ELR13499.1 - 0.052 13.8 5.4 0.12 12.7 5.4 1.6 1 0 0 1 1 1 0 RING-H2 zinc finger domain Pox_Ag35 PF03286.14 ELR13499.1 - 0.16 11.7 21.2 1.2 8.9 9.8 2.8 2 0 0 2 2 2 0 Pox virus Ag35 surface protein Miga PF10265.9 ELR13499.1 - 0.64 8.9 2.9 1.4 7.8 2.9 1.5 1 0 0 1 1 1 0 Mitoguardin Afi1 PF07792.12 ELR13499.1 - 8.3 6.9 14.0 4.2 7.9 7.4 3.0 2 0 0 2 2 2 0 Docking domain of Afi1 for Arf3 in vesicle trafficking ERCC4 PF02732.15 ELR13500.1 - 3.9e-23 82.4 0.0 7.9e-23 81.4 0.0 1.6 1 0 0 1 1 1 1 ERCC4 domain HHH_8 PF14716.6 ELR13500.1 - 3.9e-06 27.1 0.0 2e-05 24.8 0.0 2.3 1 0 0 1 1 1 1 Helix-hairpin-helix domain HHH_5 PF14520.6 ELR13500.1 - 0.0064 17.1 0.0 0.34 11.5 0.0 2.5 2 0 0 2 2 2 1 Helix-hairpin-helix domain DUF4364 PF14277.6 ELR13500.1 - 0.036 13.8 0.0 0.077 12.7 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4364) HxlR PF01638.17 ELR13500.1 - 0.062 13.2 0.1 0.23 11.4 0.0 1.9 2 0 0 2 2 2 0 HxlR-like helix-turn-helix CbiG_C PF01890.16 ELR13500.1 - 0.15 12.6 2.9 25 5.5 0.2 3.3 3 0 0 3 3 3 0 Cobalamin synthesis G C-terminus Nucleo_P87 PF07267.11 ELR13500.1 - 7.7 5.2 15.1 0.94 8.3 2.7 3.1 3 0 0 3 3 3 0 Nucleopolyhedrovirus capsid protein P87 WD40 PF00400.32 ELR13502.1 - 2e-10 41.0 6.2 1.5e-05 25.7 0.0 5.6 6 0 0 6 6 6 3 WD domain, G-beta repeat Y1_Tnp PF01797.16 ELR13502.1 - 0.13 12.4 0.0 0.25 11.4 0.0 1.5 1 0 0 1 1 1 0 Transposase IS200 like Ras PF00071.22 ELR13503.1 - 8.8e-47 158.7 0.0 1e-46 158.5 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR13503.1 - 1.3e-30 106.1 0.0 1.9e-30 105.6 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR13503.1 - 9.1e-09 35.0 0.0 1.3e-08 34.6 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 ELR13503.1 - 0.0013 18.7 0.0 0.0024 17.9 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 ELR13503.1 - 0.0059 16.2 0.0 0.11 12.0 0.0 2.3 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain AAA_16 PF13191.6 ELR13503.1 - 0.07 13.5 0.0 0.15 12.4 0.0 1.6 2 0 0 2 2 2 0 AAA ATPase domain Gtr1_RagA PF04670.12 ELR13503.1 - 0.21 10.9 0.0 0.88 8.9 0.0 1.9 1 1 0 1 1 1 0 Gtr1/RagA G protein conserved region G-alpha PF00503.20 ELR13503.1 - 0.28 10.3 0.0 7.3 5.6 0.0 2.1 2 0 0 2 2 2 0 G-protein alpha subunit DEC-1_N PF04625.13 ELR13504.1 - 0.3 10.0 5.9 0.3 10.1 5.9 1.1 1 0 0 1 1 1 0 DEC-1 protein, N-terminal region CAP_N PF01213.19 ELR13504.1 - 1.5 8.2 10.7 2.1 7.7 10.7 1.4 1 1 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal SRA1 PF07304.11 ELR13504.1 - 4.7 7.0 9.2 2.8 7.7 0.0 2.1 2 0 0 2 2 2 0 Steroid receptor RNA activator (SRA1) PRIMA1 PF16101.5 ELR13504.1 - 9.7 6.3 12.4 19 5.3 12.4 1.4 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 EF-hand_1 PF00036.32 ELR13505.1 - 7.2e-11 40.8 0.1 0.0029 17.1 0.0 3.6 4 0 0 4 4 4 3 EF hand EF-hand_7 PF13499.6 ELR13505.1 - 1.4e-10 41.5 0.0 5.5e-08 33.2 0.0 2.4 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 ELR13505.1 - 1e-09 37.5 0.5 0.013 15.4 0.0 3.5 3 0 0 3 3 3 3 EF-hand domain EF-hand_5 PF13202.6 ELR13505.1 - 9.9e-08 31.2 0.2 0.082 12.4 0.0 3.3 3 0 0 3 3 3 2 EF hand EF-hand_8 PF13833.6 ELR13505.1 - 3.2e-06 26.9 0.1 0.016 15.1 0.0 3.2 2 1 1 3 3 3 2 EF-hand domain pair DUF5580 PF17743.1 ELR13505.1 - 0.02 13.4 0.0 0.027 13.1 0.0 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5580) AAA_5 PF07728.14 ELR13508.1 - 5.2e-85 282.4 0.3 5.9e-30 104.1 0.1 4.4 3 1 1 4 4 4 4 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 ELR13508.1 - 9.2e-12 45.7 5.3 3.3e-06 27.6 0.3 5.1 3 1 0 4 4 4 2 AAA ATPase domain AAA_22 PF13401.6 ELR13508.1 - 3.7e-09 37.0 0.5 0.00074 19.8 0.1 4.2 2 2 0 2 2 2 2 AAA domain AAA PF00004.29 ELR13508.1 - 1.4e-06 28.7 0.1 0.039 14.4 0.0 3.4 3 0 0 3 3 2 2 ATPase family associated with various cellular activities (AAA) AAA_14 PF13173.6 ELR13508.1 - 1.6e-06 28.2 0.0 0.021 14.8 0.0 3.1 3 0 0 3 3 2 2 AAA domain ABC_tran PF00005.27 ELR13508.1 - 2.9e-06 27.8 0.8 0.00048 20.7 0.0 3.0 3 0 0 3 3 2 1 ABC transporter VWA PF00092.28 ELR13508.1 - 1.6e-05 25.2 0.0 3.5e-05 24.1 0.0 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain AAA_7 PF12775.7 ELR13508.1 - 4.2e-05 23.1 0.0 0.12 11.8 0.0 2.4 2 0 0 2 2 2 2 P-loop containing dynein motor region AAA_33 PF13671.6 ELR13508.1 - 4.5e-05 23.6 0.1 0.016 15.4 0.0 3.4 3 0 0 3 3 2 1 AAA domain AAA_18 PF13238.6 ELR13508.1 - 5.6e-05 23.7 0.0 0.0032 18.0 0.0 3.0 2 0 0 2 2 2 1 AAA domain AAA_2 PF07724.14 ELR13508.1 - 6.1e-05 23.2 5.2 0.14 12.3 0.0 3.8 4 0 0 4 4 4 2 AAA domain (Cdc48 subfamily) AAA_29 PF13555.6 ELR13508.1 - 6.7e-05 22.5 0.0 0.023 14.4 0.0 2.5 2 0 0 2 2 2 1 P-loop containing region of AAA domain CbbQ_C PF08406.10 ELR13508.1 - 0.00016 21.9 1.7 0.76 10.1 0.3 4.2 3 0 0 3 3 3 1 CbbQ/NirQ/NorQ C-terminal Mg_chelatase PF01078.21 ELR13508.1 - 0.00025 20.5 0.7 0.25 10.7 0.0 3.0 3 0 0 3 3 3 2 Magnesium chelatase, subunit ChlI RsgA_GTPase PF03193.16 ELR13508.1 - 0.00076 19.4 0.0 0.23 11.4 0.0 2.5 2 0 0 2 2 2 1 RsgA GTPase AAA_3 PF07726.11 ELR13508.1 - 0.00082 19.2 0.1 1.3 8.9 0.0 3.7 3 0 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) SMC_N PF02463.19 ELR13508.1 - 0.0015 18.0 0.0 0.0054 16.2 0.0 1.8 2 0 0 2 2 2 1 RecF/RecN/SMC N terminal domain VWA_2 PF13519.6 ELR13508.1 - 0.0015 19.1 0.0 0.0094 16.6 0.0 2.5 1 0 0 1 1 1 1 von Willebrand factor type A domain TsaE PF02367.17 ELR13508.1 - 0.0019 18.2 0.1 0.69 9.9 0.0 2.6 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_24 PF13479.6 ELR13508.1 - 0.0027 17.4 0.0 0.037 13.7 0.0 2.3 2 0 0 2 2 2 1 AAA domain ATPase_2 PF01637.18 ELR13508.1 - 0.0028 17.6 0.3 0.035 14.0 0.0 2.5 3 0 0 3 3 2 1 ATPase domain predominantly from Archaea RNA_helicase PF00910.22 ELR13508.1 - 0.003 17.9 0.0 0.26 11.7 0.0 2.5 2 0 0 2 2 2 1 RNA helicase G-alpha PF00503.20 ELR13508.1 - 0.003 16.8 0.0 0.0058 15.8 0.0 1.4 1 0 0 1 1 1 1 G-protein alpha subunit NACHT PF05729.12 ELR13508.1 - 0.0032 17.4 0.1 0.12 12.2 0.0 3.0 3 0 0 3 3 2 1 NACHT domain Roc PF08477.13 ELR13508.1 - 0.0033 17.6 0.0 1.5 9.1 0.0 2.5 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase TniB PF05621.11 ELR13508.1 - 0.0048 16.3 0.0 1.8 7.9 0.0 2.7 2 0 0 2 2 2 1 Bacterial TniB protein AAA_28 PF13521.6 ELR13508.1 - 0.0079 16.5 1.8 0.022 15.0 0.0 2.8 4 0 0 4 4 1 1 AAA domain Cytidylate_kin PF02224.18 ELR13508.1 - 0.048 13.4 0.2 0.16 11.7 0.0 2.0 2 0 0 2 2 1 0 Cytidylate kinase AAA_23 PF13476.6 ELR13508.1 - 0.06 13.9 0.6 0.24 11.9 0.0 2.1 2 0 0 2 2 2 0 AAA domain Rad17 PF03215.15 ELR13508.1 - 0.065 13.2 0.0 0.51 10.2 0.0 2.3 2 0 0 2 2 2 0 Rad17 P-loop domain NTPase_1 PF03266.15 ELR13508.1 - 0.086 12.8 0.0 4.2 7.2 0.0 2.8 2 0 0 2 2 2 0 NTPase Viral_helicase1 PF01443.18 ELR13508.1 - 0.087 12.5 0.2 29 4.3 0.0 3.2 4 0 0 4 4 3 0 Viral (Superfamily 1) RNA helicase DNA_pol3_delta2 PF13177.6 ELR13508.1 - 0.1 12.4 0.5 7.8 6.3 0.0 3.4 3 1 1 4 4 4 0 DNA polymerase III, delta subunit ATP_bind_1 PF03029.17 ELR13508.1 - 0.11 12.2 0.1 0.99 9.1 0.1 2.3 2 1 0 2 2 2 0 Conserved hypothetical ATP binding protein Guanylate_kin PF00625.21 ELR13508.1 - 0.75 9.4 2.8 11 5.6 0.0 3.3 3 0 0 3 3 3 0 Guanylate kinase BTB_2 PF02214.22 ELR13509.1 - 2.1e-21 76.0 0.0 5.7e-21 74.7 0.0 1.7 2 0 0 2 2 2 1 BTB/POZ domain BTB_3 PF16017.5 ELR13509.1 - 2.2e-05 24.5 0.0 4e-05 23.7 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain D5_N PF08706.11 ELR13509.1 - 0.092 13.0 1.4 0.25 11.6 1.4 1.9 1 1 1 2 2 2 0 D5 N terminal like HEAT PF02985.22 ELR13512.1 - 0.0005 20.1 1.1 0.14 12.5 0.0 4.4 5 0 0 5 5 5 1 HEAT repeat HEAT_EZ PF13513.6 ELR13512.1 - 0.0012 19.3 1.2 1.1 9.9 0.1 5.0 5 1 1 6 6 6 2 HEAT-like repeat Ubiq_cyt_C_chap PF03981.12 ELR13512.1 - 0.028 14.5 0.1 0.053 13.6 0.1 1.4 1 0 0 1 1 1 0 Ubiquinol-cytochrome C chaperone Arm PF00514.23 ELR13512.1 - 0.035 14.2 0.0 1.8 8.7 0.0 3.0 3 0 0 3 3 3 0 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.6 ELR13513.1 - 0.0049 17.2 0.0 0.35 11.3 0.0 2.5 2 1 0 2 2 2 1 HEAT repeats HEAT PF02985.22 ELR13513.1 - 0.01 16.0 0.3 2 8.9 0.0 3.1 2 1 1 3 3 3 0 HEAT repeat ICMT PF04140.14 ELR13514.1 - 3.5e-15 56.2 3.7 4.8e-13 49.3 3.7 2.1 1 1 0 1 1 1 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family PEMT PF04191.13 ELR13514.1 - 1.8e-10 41.1 0.5 1e-06 29.1 0.1 2.1 1 1 1 2 2 2 2 Phospholipid methyltransferase PATR PF12951.7 ELR13514.1 - 0.18 11.9 0.0 0.3 11.2 0.0 1.4 1 0 0 1 1 1 0 Passenger-associated-transport-repeat DUF2514 PF10721.9 ELR13516.1 - 0.25 11.3 0.1 0.25 11.3 0.1 2.8 3 1 1 4 4 4 0 Protein of unknown function (DUF2514) Glyco_hydro_53 PF07745.13 ELR13517.1 - 0.088 11.8 0.3 0.14 11.1 0.3 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase family 53 ICMT PF04140.14 ELR13518.1 - 4.7e-14 52.6 8.2 6.3e-13 49.0 4.7 2.5 2 1 0 2 2 2 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family PEMT PF04191.13 ELR13518.1 - 6.1e-10 39.5 5.6 1.2e-07 32.1 0.3 2.8 2 1 1 3 3 3 2 Phospholipid methyltransferase Cupin_8 PF13621.6 ELR13519.1 - 3.6e-54 184.2 0.1 1.5e-53 182.1 0.0 1.9 2 0 0 2 2 2 1 Cupin-like domain Cupin_4 PF08007.12 ELR13519.1 - 0.00062 19.3 0.1 0.0083 15.6 0.0 2.2 2 0 0 2 2 2 1 Cupin superfamily protein JmjC PF02373.22 ELR13519.1 - 0.0055 17.1 0.1 0.034 14.6 0.0 2.3 3 0 0 3 3 3 1 JmjC domain, hydroxylase ARD PF03079.14 ELR13519.1 - 0.36 11.0 0.0 0.36 11.0 0.0 2.7 3 0 0 3 3 3 0 ARD/ARD' family 2OG-FeII_Oxy_5 PF13759.6 ELR13519.1 - 0.49 10.8 2.5 1 9.8 0.0 2.7 2 1 1 3 3 3 0 Putative 2OG-Fe(II) oxygenase Apc15p PF05841.11 ELR13519.1 - 0.83 10.5 11.2 0.47 11.3 5.8 2.4 2 0 0 2 2 2 0 Apc15p protein Nop53 PF07767.11 ELR13519.1 - 0.85 8.9 24.7 0.72 9.2 14.3 2.1 2 0 0 2 2 2 0 Nop53 (60S ribosomal biogenesis) Pex14_N PF04695.13 ELR13519.1 - 1.1 10.0 7.5 1.7 9.3 4.6 2.2 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region KdpC PF02669.15 ELR13519.1 - 2 8.2 4.8 2 8.2 2.5 2.0 2 0 0 2 2 2 0 K+-transporting ATPase, c chain Rtf2 PF04641.12 ELR13519.1 - 2.1 7.7 15.4 1.4 8.2 2.6 2.3 2 0 0 2 2 2 0 Rtf2 RING-finger XAP5 PF04921.14 ELR13519.1 - 6.6 6.5 18.7 0.29 10.9 4.9 2.3 2 0 0 2 2 2 0 XAP5, circadian clock regulator HATPase_c PF02518.26 ELR13520.1 - 2.8e-25 89.0 0.1 5.6e-25 88.0 0.1 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 ELR13520.1 - 2.1e-21 76.2 0.0 5.7e-21 74.8 0.0 1.8 1 0 0 1 1 1 1 Response regulator receiver domain PAS_9 PF13426.7 ELR13520.1 - 1.9e-12 47.3 0.2 5.3e-12 45.9 0.2 1.8 1 0 0 1 1 1 1 PAS domain PAS_4 PF08448.10 ELR13520.1 - 3.7e-11 43.2 0.0 1.8e-10 41.1 0.0 2.1 2 0 0 2 2 2 1 PAS fold HisKA PF00512.25 ELR13520.1 - 4.6e-11 42.6 0.3 2.5e-10 40.3 0.1 2.4 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain PAS PF00989.25 ELR13520.1 - 2.1e-08 34.1 0.0 5.3e-08 32.8 0.0 1.8 1 0 0 1 1 1 1 PAS fold PAS_8 PF13188.7 ELR13520.1 - 0.00011 22.1 0.0 0.00034 20.5 0.0 1.9 1 0 0 1 1 1 1 PAS domain PAS_10 PF13596.6 ELR13520.1 - 0.048 14.2 0.0 0.11 13.1 0.0 1.6 1 0 0 1 1 1 0 PAS domain DUF1263 PF06882.12 ELR13520.1 - 0.076 13.1 0.0 0.18 11.9 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1263) MEKHLA PF08670.11 ELR13520.1 - 0.078 12.9 0.0 0.16 11.9 0.0 1.4 1 0 0 1 1 1 0 MEKHLA domain MBD PF01429.19 ELR13521.1 - 0.031 14.0 0.0 0.078 12.7 0.0 1.7 1 0 0 1 1 1 0 Methyl-CpG binding domain Rubis-subs-bind PF09273.11 ELR13522.1 - 1.3e-14 55.0 1.2 1.3e-14 55.0 1.2 2.3 3 0 0 3 3 3 1 Rubisco LSMT substrate-binding SET PF00856.28 ELR13522.1 - 3.3e-10 40.6 0.1 1.5e-09 38.5 0.0 2.2 2 2 0 2 2 2 1 SET domain Beta-lactamase PF00144.24 ELR13524.1 - 7.1e-23 81.4 0.1 9.2e-23 81.0 0.1 1.1 1 0 0 1 1 1 1 Beta-lactamase SDA1 PF05285.12 ELR13525.1 - 1.2 8.5 33.1 1.9 7.8 33.1 1.2 1 0 0 1 1 1 0 SDA1 Baculo_PEP_C PF04513.12 ELR13526.1 - 5.1 7.1 14.2 0.16 12.0 5.8 2.8 2 1 2 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus 4HB_MCP_1 PF12729.7 ELR13527.1 - 0.00016 21.3 6.3 0.19 11.2 2.6 2.7 1 1 1 2 2 2 2 Four helix bundle sensory module for signal transduction Baculo_PEP_C PF04513.12 ELR13527.1 - 0.0004 20.5 29.9 0.22 11.6 1.2 4.9 2 1 2 4 4 4 2 Baculovirus polyhedron envelope protein, PEP, C terminus EIIA-man PF03610.16 ELR13527.1 - 0.06 13.6 3.3 0.18 12.0 1.5 2.8 2 1 0 2 2 2 0 PTS system fructose IIA component Kri1 PF05178.12 ELR13527.1 - 0.071 13.7 0.9 0.32 11.6 0.9 2.2 1 1 0 1 1 1 0 KRI1-like family Tli4_N PF18443.1 ELR13527.1 - 0.16 12.4 6.2 0.16 12.3 1.5 2.6 2 0 0 2 2 2 0 Tle cognate immunity protein 4 N-terminal domain FAM167 PF11652.8 ELR13527.1 - 0.25 11.8 0.1 0.25 11.8 0.1 3.0 2 1 1 3 3 3 0 FAM167 Syntaxin-6_N PF09177.11 ELR13527.1 - 0.27 11.8 8.0 76 3.9 0.0 4.2 3 1 0 3 3 3 0 Syntaxin 6, N-terminal Phage_pRha PF09669.10 ELR13527.1 - 0.83 10.2 5.0 0.68 10.5 0.5 3.0 2 1 1 3 3 3 0 Phage regulatory protein Rha (Phage_pRha) Corona_S2 PF01601.16 ELR13527.1 - 2.5 6.5 13.7 0.14 10.6 7.1 1.9 1 1 1 2 2 2 0 Coronavirus S2 glycoprotein ACCA PF03255.14 ELR13527.1 - 2.7 7.9 12.6 0.91 9.4 2.6 3.4 2 1 2 4 4 4 0 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit MitMem_reg PF13012.6 ELR13527.1 - 5.4 7.5 17.0 0.98 9.9 0.9 3.5 1 1 2 3 3 3 0 Maintenance of mitochondrial structure and function Matrilin_ccoil PF10393.9 ELR13527.1 - 6.1 6.8 7.6 29 4.6 0.0 3.8 3 0 0 3 3 3 0 Trimeric coiled-coil oligomerisation domain of matrilin AI-2E_transport PF01594.16 ELR13527.1 - 9.3 5.3 12.1 3.2 6.8 1.3 3.0 2 1 1 3 3 3 0 AI-2E family transporter SKA2 PF16740.5 ELR13527.1 - 9.4 6.1 20.8 5.6 6.8 1.4 4.4 2 1 1 4 4 4 0 Spindle and kinetochore-associated protein 2 TGT PF01702.18 ELR13528.1 - 2.6e-25 89.3 0.1 4.9e-25 88.4 0.1 1.4 1 0 0 1 1 1 1 Queuine tRNA-ribosyltransferase RhoGEF PF00621.20 ELR13533.1 - 3.8e-17 63.1 0.4 1.9e-15 57.6 0.4 2.0 1 1 0 1 1 1 1 RhoGEF domain IQ PF00612.27 ELR13533.1 - 0.0014 18.2 1.3 0.0014 18.2 1.3 2.1 2 0 0 2 2 2 1 IQ calmodulin-binding motif IQ_SEC7_PH PF16453.5 ELR13534.1 - 0.007 16.3 0.0 0.012 15.6 0.0 1.2 1 0 0 1 1 1 1 PH domain PH_13 PF16652.5 ELR13534.1 - 0.07 12.9 0.3 0.21 11.4 0.3 1.7 1 1 0 1 1 1 0 Pleckstrin homology domain DUF5615 PF18480.1 ELR13535.1 - 0.098 12.4 0.0 7.3 6.4 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF5615) CDC45 PF02724.14 ELR13536.1 - 0.03 12.7 15.1 0.031 12.6 15.1 1.0 1 0 0 1 1 1 0 CDC45-like protein DUF2457 PF10446.9 ELR13536.1 - 1.3 8.1 20.0 1.5 7.9 20.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Nop14 PF04147.12 ELR13536.1 - 1.5 6.9 16.4 1.7 6.8 16.4 1.0 1 0 0 1 1 1 0 Nop14-like family SDA1 PF05285.12 ELR13536.1 - 1.6 8.1 19.5 1.9 7.9 19.5 1.0 1 0 0 1 1 1 0 SDA1 XRCC4 PF06632.12 ELR13536.1 - 1.9 7.2 8.2 2.4 6.9 8.2 1.1 1 0 0 1 1 1 0 DNA double-strand break repair and V(D)J recombination protein XRCC4 Trypan_PARP PF05887.11 ELR13536.1 - 3.3 7.7 10.3 4.9 7.1 10.3 1.3 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) CDC27 PF09507.10 ELR13536.1 - 4.4 6.6 15.1 5 6.4 15.1 1.0 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 RVT_1 PF00078.27 ELR13538.1 - 2e-13 50.4 0.0 5e-13 49.1 0.0 1.6 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Phage_integrase PF00589.22 ELR13539.1 - 8.1e-08 32.2 0.0 2.7e-06 27.3 0.0 2.0 1 1 0 1 1 1 1 Phage integrase family Acetyltransf_6 PF13480.7 ELR13539.1 - 0.032 14.4 0.0 0.04 14.1 0.0 1.1 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain CMD PF02627.20 ELR13539.1 - 0.087 12.9 0.2 0.16 12.1 0.1 1.5 1 1 1 2 2 2 0 Carboxymuconolactone decarboxylase family IU_nuc_hydro PF01156.19 ELR13543.1 - 0.00076 19.1 0.0 0.0014 18.3 0.0 1.4 1 0 0 1 1 1 1 Inosine-uridine preferring nucleoside hydrolase ETX_MTX2 PF03318.13 ELR13543.1 - 0.0047 16.7 0.6 0.0068 16.2 0.6 1.1 1 0 0 1 1 1 1 Clostridium epsilon toxin ETX/Bacillus mosquitocidal toxin MTX2 CAF1 PF04857.20 ELR13545.1 - 4.2 6.4 8.1 18 4.4 8.1 2.0 1 1 0 1 1 1 0 CAF1 family ribonuclease SDA1 PF05285.12 ELR13545.1 - 8.8 5.6 39.7 15 4.8 39.7 1.4 1 0 0 1 1 1 0 SDA1 PBP1_TM PF14812.6 ELR13546.1 - 0.0021 18.4 0.5 0.0021 18.4 0.5 1.7 2 0 0 2 2 2 1 Transmembrane domain of transglycosylase PBP1 at N-terminal Osteopontin PF00865.18 ELR13546.1 - 0.0077 15.8 2.0 0.012 15.1 2.0 1.3 1 0 0 1 1 1 1 Osteopontin DUF3245 PF11595.8 ELR13546.1 - 7.3 7.1 7.5 0.41 11.1 2.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3245) RRM_1 PF00076.22 ELR13547.1 - 6.2e-24 83.6 0.0 7e-24 83.4 0.0 1.0 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 ELR13547.1 - 0.00022 21.3 0.0 0.00028 20.9 0.0 1.3 1 1 0 1 1 1 1 RNA recognition motif RRM_8 PF11835.8 ELR13547.1 - 0.0068 16.6 0.0 0.0085 16.3 0.0 1.1 1 0 0 1 1 1 1 RRM-like domain RRM_Rrp7 PF17799.1 ELR13547.1 - 0.054 13.3 0.0 0.12 12.2 0.0 1.5 1 1 1 2 2 2 0 Rrp7 RRM-like N-terminal domain PHM7_cyt PF14703.6 ELR13547.1 - 0.074 13.3 0.0 0.26 11.5 0.0 1.7 1 1 1 2 2 2 0 Cytosolic domain of 10TM putative phosphate transporter Spo7_2_N PF15407.6 ELR13547.1 - 0.096 12.3 0.0 0.12 12.0 0.0 1.2 1 0 0 1 1 1 0 Sporulation protein family 7 RRM_occluded PF16842.5 ELR13547.1 - 0.17 11.7 0.0 0.34 10.8 0.0 1.5 1 1 0 1 1 1 0 Occluded RNA-recognition motif PNMA PF14893.6 ELR13547.1 - 0.26 10.6 0.0 0.28 10.5 0.0 1.1 1 0 0 1 1 1 0 PNMA Sec1 PF00995.23 ELR13548.1 - 4.5e-66 224.3 0.0 1.2e-63 216.3 0.0 2.0 1 1 0 1 1 1 1 Sec1 family Pro-kuma_activ PF09286.11 ELR13549.1 - 6.8e-19 68.6 0.0 2.7e-18 66.7 0.0 2.0 2 0 0 2 2 2 1 Pro-kumamolisin, activation domain Peptidase_S8 PF00082.22 ELR13549.1 - 1.1e-05 24.9 10.5 2.9e-05 23.5 10.5 1.6 1 1 0 1 1 1 1 Subtilase family Sporozoite_P67 PF05642.11 ELR13550.1 - 2.8 5.9 3.8 3.8 5.5 3.8 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen ADP_ribosyl_GH PF03747.14 ELR13551.1 - 1.4e-35 123.4 0.5 2.1e-26 93.3 0.1 2.1 1 1 1 2 2 2 2 ADP-ribosylglycohydrolase Sec10 PF07393.11 ELR13552.1 - 2.2e-120 403.3 11.3 3e-118 396.2 11.3 2.9 1 1 0 1 1 1 1 Exocyst complex component Sec10 Sec16_C PF12931.7 ELR13553.1 - 5e-08 33.0 1.6 8.6e-08 32.2 0.3 2.1 2 0 0 2 2 2 1 Sec23-binding domain of Sec16 Adaptin_binding PF10199.9 ELR13553.1 - 0.15 12.7 5.5 0.22 12.1 3.9 2.0 2 0 0 2 2 2 0 Alpha and gamma adaptin binding protein p34 CoiA PF06054.11 ELR13553.1 - 0.23 10.6 0.0 0.36 9.9 0.0 1.2 1 0 0 1 1 1 0 Competence protein CoiA-like family Mak16 PF04874.14 ELR13553.1 - 0.27 11.9 16.5 7.3 7.3 0.1 2.4 2 0 0 2 2 2 0 Mak16 protein C-terminal region Clathrin PF00637.20 ELR13553.1 - 0.6 10.0 3.6 0.72 9.7 0.0 2.7 3 1 1 4 4 4 0 Region in Clathrin and VPS Astro_capsid_p PF12226.8 ELR13553.1 - 1 8.4 3.8 1.6 7.8 3.8 1.2 1 0 0 1 1 1 0 Turkey astrovirus capsid protein TRAP_alpha PF03896.16 ELR13553.1 - 1.5 8.0 3.6 2.5 7.3 3.6 1.2 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit DNA_pol_phi PF04931.13 ELR13553.1 - 2.5 6.1 10.5 3 5.8 9.4 1.6 2 0 0 2 2 2 0 DNA polymerase phi DUF4637 PF15470.6 ELR13553.1 - 3.4 7.4 9.5 6.6 6.4 9.5 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) APH PF01636.23 ELR13554.1 - 2.1e-07 31.1 0.7 4e-05 23.7 0.2 2.1 1 1 1 2 2 2 2 Phosphotransferase enzyme family Pkinase PF00069.25 ELR13554.1 - 7.5e-05 22.2 0.0 0.00011 21.7 0.0 1.3 1 1 0 1 1 1 1 Protein kinase domain Pkinase_fungal PF17667.1 ELR13554.1 - 0.0028 16.5 0.0 0.0038 16.0 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Pkinase_Tyr PF07714.17 ELR13554.1 - 0.0029 17.0 0.1 0.0036 16.6 0.1 1.3 1 1 0 1 1 1 1 Protein tyrosine kinase RIO1 PF01163.22 ELR13554.1 - 0.0039 16.8 0.1 0.011 15.3 0.1 1.8 1 1 1 2 2 2 1 RIO1 family Tmemb_18A PF09771.9 ELR13554.1 - 0.054 13.9 0.1 0.15 12.4 0.0 1.7 2 0 0 2 2 2 0 Transmembrane protein 188 Phage_integrase PF00589.22 ELR13555.1 - 0.05 13.4 0.0 0.08 12.7 0.0 1.3 1 0 0 1 1 1 0 Phage integrase family Capsid_NCLDV PF04451.12 ELR13556.1 - 2.7e-37 128.5 0.0 3.9e-37 128.0 0.0 1.2 1 0 0 1 1 1 1 Large eukaryotic DNA virus major capsid protein WD40 PF00400.32 ELR13558.1 - 9.1e-05 23.2 0.3 0.02 15.7 0.0 3.2 3 1 0 3 3 3 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ELR13558.1 - 0.0019 18.4 0.0 0.0026 18.0 0.0 1.3 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 ELR13558.1 - 0.014 15.2 0.0 0.016 15.1 0.0 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor eIF2A Pyr_redox_2 PF07992.14 ELR13559.1 - 8.6e-29 100.7 0.0 1.1e-28 100.4 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 ELR13559.1 - 6.5e-06 26.6 0.2 0.06 13.9 0.2 2.5 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 ELR13559.1 - 0.0029 17.8 0.1 1.7 8.9 0.0 2.8 2 0 0 2 2 2 2 NAD(P)-binding Rossmann-like domain HhH-GPD PF00730.25 ELR13561.1 - 3.7e-10 40.2 0.0 4.7e-10 39.9 0.0 1.1 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein 3HCDH_RFF PF18321.1 ELR13561.1 - 0.0014 19.0 0.1 0.0019 18.6 0.1 1.2 1 0 0 1 1 1 1 3-hydroxybutyryl-CoA dehydrogenase reduced Rossmann-fold domain LIDHydrolase PF10230.9 ELR13563.1 - 5.7e-46 157.2 0.0 7.5e-46 156.8 0.0 1.1 1 0 0 1 1 1 1 Lipid-droplet associated hydrolase Abhydrolase_4 PF08386.10 ELR13563.1 - 1.2e-05 25.3 0.0 2e-05 24.6 0.0 1.2 1 0 0 1 1 1 1 TAP-like protein Abhydrolase_1 PF00561.20 ELR13563.1 - 0.00011 21.9 0.0 0.013 15.1 0.0 2.3 2 0 0 2 2 2 2 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 ELR13563.1 - 0.00024 20.4 0.0 0.0051 16.1 0.0 2.2 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 ELR13563.1 - 0.00069 20.3 0.1 0.00093 19.9 0.1 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Lipase_3 PF01764.25 ELR13563.1 - 0.035 14.0 0.0 0.065 13.1 0.0 1.4 1 0 0 1 1 1 0 Lipase (class 3) DUF1749 PF08538.10 ELR13563.1 - 0.041 13.0 0.0 0.13 11.3 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1749) DLH PF01738.18 ELR13563.1 - 0.15 11.6 0.0 11 5.4 0.0 2.1 2 0 0 2 2 2 0 Dienelactone hydrolase family Sel1 PF08238.12 ELR13564.1 - 2e-71 234.8 73.6 1.9e-08 34.7 0.0 14.1 14 1 0 14 14 14 13 Sel1 repeat ANAPC3 PF12895.7 ELR13564.1 - 0.14 12.4 5.8 0.18 12.0 0.3 3.8 3 1 0 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 Nepo_coat_N PF03689.15 ELR13564.1 - 0.17 11.8 0.0 1.2 9.2 0.0 2.2 2 0 0 2 2 2 0 Nepovirus coat protein, N-terminal domain Baculo_PEP_C PF04513.12 ELR13565.1 - 0.36 10.9 2.8 0.43 10.6 0.6 2.0 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Zip PF02535.22 ELR13566.1 - 1.1e-12 47.8 2.7 1.3e-11 44.3 0.1 2.1 1 1 1 2 2 2 2 ZIP Zinc transporter Peptidase_C12 PF01088.21 ELR13567.1 - 7.4e-65 218.6 0.0 2.4e-64 217.0 0.0 1.8 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase, family 1 UCH_C PF18031.1 ELR13567.1 - 3.5e-21 74.8 1.2 3.5e-21 74.8 1.2 2.5 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolases SH3_9 PF14604.6 ELR13568.1 - 8.8e-31 105.5 2.8 4.6e-17 61.6 0.2 2.5 2 0 0 2 2 2 2 Variant SH3 domain SH3_1 PF00018.28 ELR13568.1 - 7.8e-29 99.0 2.0 4.7e-15 54.9 0.2 3.1 3 0 0 3 3 3 2 SH3 domain SH3_2 PF07653.17 ELR13568.1 - 1.1e-24 85.9 1.3 1.2e-11 44.1 0.1 3.3 3 0 0 3 3 3 2 Variant SH3 domain FCH PF00611.23 ELR13568.1 - 8.5e-05 22.8 0.2 8.5e-05 22.8 0.2 2.7 3 0 0 3 3 3 1 Fes/CIP4, and EFC/F-BAR homology domain Hemerythrin PF01814.23 ELR13569.1 - 1.1e-05 26.0 0.1 6.8e-05 23.5 0.0 1.9 2 0 0 2 2 2 1 Hemerythrin HHE cation binding domain DUF4754 PF15946.5 ELR13570.1 - 1.9e-11 44.1 31.1 1.6 9.1 0.0 13.9 16 0 0 16 16 16 6 Domain of unknown function (DUF4754) PDE4_UCR PF18100.1 ELR13570.1 - 4.7e-10 40.1 33.1 7.2 7.3 0.1 16.0 9 4 7 19 19 19 2 Phosphodiesterase 4 upstream conserved regions (UCR) Pox_TAA1 PF03295.14 ELR13570.1 - 2.5e-05 24.1 0.6 69 3.4 0.0 7.9 9 0 0 9 9 9 0 Poxvirus trans-activator protein A1 C-terminal SPACA9 PF15120.6 ELR13570.1 - 5.3e-05 23.1 18.9 3.9 7.2 0.1 9.4 5 2 4 10 10 10 2 Sperm acrosome-associated protein 9 Rota_NSP3 PF01665.16 ELR13570.1 - 0.0017 17.6 22.5 4 6.5 0.1 8.9 3 1 7 11 11 11 3 Rotavirus non-structural protein NSP3 STN1_2 PF09170.10 ELR13570.1 - 0.0077 16.5 32.7 4.7 7.4 0.1 12.4 4 2 12 16 16 16 2 CST, Suppressor of cdc thirteen homolog, complex subunit STN1 DUF3232 PF11554.8 ELR13570.1 - 0.033 14.6 28.5 65 3.9 0.1 12.9 15 0 0 15 15 15 0 Protein of unknown function (DUF3232) DUF5537 PF17690.1 ELR13570.1 - 0.18 11.4 5.4 0.6 9.8 0.0 4.8 5 0 0 5 5 5 0 Family of unknown function (DUF5537) Hema_HEFG PF02710.14 ELR13570.1 - 2.9 8.1 11.9 88 3.3 0.1 6.6 7 0 0 7 7 7 0 Hemagglutinin domain of haemagglutinin-esterase-fusion glycoprotein LCAT PF02450.15 ELR13571.1 - 3.1e-65 220.9 0.2 1.3e-64 218.8 0.2 1.8 1 1 0 1 1 1 1 Lecithin:cholesterol acyltransferase OmpH PF03938.14 ELR13571.1 - 0.0097 16.2 4.6 0.0097 16.2 4.6 1.7 2 0 0 2 2 2 1 Outer membrane protein (OmpH-like) DUF676 PF05057.14 ELR13571.1 - 0.078 12.5 0.0 0.13 11.7 0.0 1.3 1 0 0 1 1 1 0 Putative serine esterase (DUF676) FXMR_C2 PF16098.5 ELR13571.1 - 0.83 10.2 3.2 1.7 9.2 3.2 1.4 1 0 0 1 1 1 0 Fragile X-related mental retardation protein C-terminal region 2 HpcH_HpaI PF03328.14 ELR13573.1 - 2.7e-28 98.6 0.0 1.2e-16 60.5 0.0 2.3 1 1 1 2 2 2 2 HpcH/HpaI aldolase/citrate lyase family C-C_Bond_Lyase PF15617.6 ELR13573.1 - 2.1e-06 27.2 0.1 0.0047 16.1 0.0 2.7 2 1 0 3 3 3 2 C-C_Bond_Lyase of the TIM-Barrel fold FtsK_gamma PF09397.10 ELR13574.1 - 3e-05 23.7 0.0 6.6e-05 22.6 0.0 1.6 1 0 0 1 1 1 1 Ftsk gamma domain FapA PF03961.13 ELR13574.1 - 0.32 9.6 4.4 0.11 11.1 1.9 1.5 2 0 0 2 2 2 0 Flagellar Assembly Protein A DUF4407 PF14362.6 ELR13574.1 - 0.57 9.5 11.7 1.1 8.5 11.7 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) MADF_DNA_bdg PF10545.9 ELR13574.1 - 0.71 10.2 5.0 0.29 11.5 1.3 2.2 2 0 0 2 2 2 0 Alcohol dehydrogenase transcription factor Myb/SANT-like PHM7_cyt PF14703.6 ELR13574.1 - 0.86 9.8 3.4 0.72 10.1 1.0 1.9 2 0 0 2 2 2 0 Cytosolic domain of 10TM putative phosphate transporter Lzipper-MIP1 PF14389.6 ELR13574.1 - 1.3 9.3 7.3 19 5.6 3.7 3.0 2 1 1 3 3 3 0 Leucine-zipper of ternary complex factor MIP1 DUF641 PF04859.12 ELR13574.1 - 4.8 7.5 9.3 2.2 8.7 6.6 1.8 2 0 0 2 2 2 0 Plant protein of unknown function (DUF641) Apc13p PF05839.11 ELR13575.1 - 5.8 7.2 7.7 0.83 9.9 1.0 3.0 3 0 0 3 3 3 0 Apc13p protein PP2C_2 PF13672.6 ELR13576.1 - 8.7e-09 35.3 0.5 3.7e-08 33.3 0.0 1.9 1 1 1 2 2 2 1 Protein phosphatase 2C DUF4398 PF14346.6 ELR13576.1 - 1.7 9.3 7.0 3.4 8.3 7.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4398) Actin PF00022.19 ELR13577.1 - 1e-64 218.7 0.0 1.1e-64 218.5 0.0 1.0 1 0 0 1 1 1 1 Actin GerD PF17898.1 ELR13577.1 - 0.16 11.9 0.1 0.26 11.3 0.1 1.3 1 0 0 1 1 1 0 Spore germination GerD central core domain Ras PF00071.22 ELR13578.1 - 8.3e-50 168.5 0.2 9.6e-50 168.3 0.2 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR13578.1 - 4.7e-28 97.8 0.2 6.8e-28 97.3 0.2 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR13578.1 - 1e-11 44.6 0.1 1.1e-11 44.5 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 ELR13578.1 - 4.4e-06 26.2 0.0 6.1e-06 25.7 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 ELR13578.1 - 9.6e-05 22.4 0.0 0.00014 21.9 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase ATP_bind_1 PF03029.17 ELR13578.1 - 0.075 12.8 0.3 1.9 8.2 0.0 2.1 1 1 1 2 2 2 0 Conserved hypothetical ATP binding protein RsgA_GTPase PF03193.16 ELR13578.1 - 0.13 12.1 0.1 8.8 6.2 0.0 2.4 2 1 1 3 3 3 0 RsgA GTPase PduV-EutP PF10662.9 ELR13578.1 - 0.15 11.8 0.3 0.64 9.8 0.3 2.1 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation BTB PF00651.31 ELR13580.1 - 1.9e-06 28.1 2.0 0.00034 20.8 0.3 2.3 1 1 1 2 2 2 2 BTB/POZ domain NPA PF16469.5 ELR13580.1 - 0.14 12.8 0.0 0.26 11.9 0.0 1.4 1 0 0 1 1 1 0 Nematode polyprotein allergen ABA-1 SR-25 PF10500.9 ELR13580.1 - 0.27 10.8 6.1 0.43 10.2 6.1 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein IMUP PF15761.5 ELR13580.1 - 0.55 10.9 14.6 1.1 9.9 14.6 1.5 1 0 0 1 1 1 0 Immortalisation up-regulated protein RCC1 PF00415.18 ELR13581.1 - 1.2e-38 131.5 13.7 1e-12 48.5 0.3 6.1 7 0 0 7 7 7 4 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 ELR13581.1 - 5.1e-23 80.3 19.2 4e-06 26.5 0.2 6.6 6 0 0 6 6 6 6 Regulator of chromosome condensation (RCC1) repeat Hira PF07569.11 ELR13581.1 - 0.0021 17.8 0.9 0.94 9.2 0.1 3.7 3 1 1 4 4 4 1 TUP1-like enhancer of split DUF4213 PF13938.6 ELR13581.1 - 0.53 10.6 3.4 27 5.1 0.0 3.6 2 1 1 3 3 3 0 Putative heavy-metal chelation HOOK PF05622.12 ELR13582.1 - 9.3e-56 189.4 69.5 4.7e-55 187.0 69.5 1.8 1 1 0 1 1 1 1 HOOK protein Fez1 PF06818.15 ELR13582.1 - 0.015 15.8 9.2 0.015 15.8 9.2 4.4 1 1 4 5 5 5 0 Fez1 HALZ PF02183.18 ELR13582.1 - 0.016 15.4 2.9 0.016 15.4 2.9 6.4 5 1 0 5 5 5 0 Homeobox associated leucine zipper KASH_CCD PF14662.6 ELR13582.1 - 0.02 14.7 80.6 0.12 12.1 26.1 4.6 3 1 1 4 4 4 0 Coiled-coil region of CCDC155 or KASH DUF5624 PF18538.1 ELR13582.1 - 3.5 7.7 7.9 1.4 9.0 0.1 3.4 2 1 1 3 3 3 0 Domain of unknown function (DUF5624) DUF4407 PF14362.6 ELR13582.1 - 3.6 6.8 50.0 0.025 13.9 8.0 4.0 2 2 1 3 3 3 0 Domain of unknown function (DUF4407) DnaJ PF00226.31 ELR13583.1 - 4.8e-20 71.5 0.1 7.2e-20 70.9 0.1 1.3 1 0 0 1 1 1 1 DnaJ domain DMA PF03474.14 ELR13583.1 - 1.1e-05 24.9 0.0 3e-05 23.5 0.0 1.8 1 0 0 1 1 1 1 DMRTA motif CUE PF02845.16 ELR13583.1 - 0.00068 19.3 0.0 0.0023 17.6 0.0 2.0 2 0 0 2 2 2 1 CUE domain NHL PF01436.21 ELR13584.1 - 1.7e-20 72.0 9.1 1.5e-09 37.4 0.5 3.3 3 0 0 3 3 3 2 NHL repeat DUF5128 PF17170.4 ELR13584.1 - 8e-07 28.5 0.0 0.005 16.0 0.0 2.0 1 1 1 2 2 2 2 6-bladed beta-propeller SGL PF08450.12 ELR13584.1 - 0.0025 17.5 0.8 0.28 10.7 0.0 2.1 1 1 1 2 2 2 2 SMP-30/Gluconolactonase/LRE-like region Arylesterase PF01731.20 ELR13584.1 - 0.014 15.6 0.0 3.8 7.8 0.0 2.1 2 0 0 2 2 2 0 Arylesterase SBBP PF06739.11 ELR13584.1 - 0.088 12.8 0.0 5.4 7.1 0.0 2.4 2 0 0 2 2 2 0 Beta-propeller repeat DUF4487 PF14868.6 ELR13585.1 - 3.7e-17 62.4 1.5 2e-15 56.6 1.5 2.4 1 1 0 1 1 1 1 Domain of unknown function (DUF4487) C2 PF00168.30 ELR13586.1 - 1.3e-09 38.2 0.0 1.6e-09 38.0 0.0 1.2 1 0 0 1 1 1 1 C2 domain NT-C2 PF10358.9 ELR13586.1 - 0.14 11.9 0.0 0.17 11.6 0.0 1.2 1 0 0 1 1 1 0 N-terminal C2 in EEIG1 and EHBP1 proteins WH2 PF02205.20 ELR13587.1 - 1.3e-06 28.0 0.2 1.3e-06 28.0 0.2 2.8 3 0 0 3 3 3 1 WH2 motif Thymosin PF01290.20 ELR13587.1 - 0.047 13.4 0.0 0.1 12.4 0.0 1.5 1 0 0 1 1 1 0 Thymosin beta-4 family Pkinase PF00069.25 ELR13588.1 - 3.5e-38 131.5 0.0 8e-38 130.3 0.0 1.6 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR13588.1 - 9.1e-22 77.6 0.0 1.6e-21 76.8 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase MMR_HSR1 PF01926.23 ELR13588.1 - 2.3e-08 34.1 0.0 1.3e-07 31.7 0.0 2.1 2 0 0 2 2 2 1 50S ribosome-binding GTPase Kinase-like PF14531.6 ELR13588.1 - 2e-06 27.4 0.0 3.6e-05 23.2 0.0 2.2 2 0 0 2 2 2 1 Kinase-like APH PF01636.23 ELR13588.1 - 0.00033 20.7 0.0 0.002 18.1 0.0 2.2 1 1 1 2 2 2 1 Phosphotransferase enzyme family Dynamin_N PF00350.23 ELR13588.1 - 0.0022 18.1 0.3 0.0077 16.3 0.2 1.9 1 1 1 2 2 2 1 Dynamin family Haspin_kinase PF12330.8 ELR13588.1 - 0.0058 15.6 0.0 0.011 14.8 0.0 1.4 1 0 0 1 1 1 1 Haspin like kinase domain ABC1 PF03109.16 ELR13588.1 - 0.061 13.5 0.0 0.14 12.3 0.0 1.5 1 0 0 1 1 1 0 ABC1 family Pkinase_fungal PF17667.1 ELR13588.1 - 0.076 11.8 0.0 0.13 11.0 0.0 1.3 1 0 0 1 1 1 0 Fungal protein kinase Mito_carr PF00153.27 ELR13590.1 - 6.7e-66 218.3 3.9 7.1e-23 80.3 0.5 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein HTH_21 PF13276.6 ELR13590.1 - 0.075 13.2 0.0 22 5.3 0.0 3.2 3 0 0 3 3 3 0 HTH-like domain Serine_protease PF18405.1 ELR13590.1 - 3.1 6.9 5.9 5.8 6.0 0.1 2.7 3 1 0 3 3 3 0 Gammaproteobacterial serine protease WD40 PF00400.32 ELR13592.1 - 9.1e-19 67.5 11.9 0.0013 19.5 0.0 7.5 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ELR13592.1 - 4.4e-09 36.5 0.1 2.5 8.5 0.0 5.2 4 1 1 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain PQQ_3 PF13570.6 ELR13592.1 - 0.031 14.8 0.4 22 5.7 0.0 3.8 4 0 0 4 4 4 0 PQQ-like domain TPR_15 PF13429.6 ELR13592.1 - 0.033 13.4 0.0 2.9 7.0 0.0 2.3 1 1 1 2 2 2 0 Tetratricopeptide repeat DUF1387 PF07139.11 ELR13592.1 - 0.21 11.3 4.8 0.24 11.1 0.8 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1387) DnaJ_C PF01556.18 ELR13593.1 - 4.8e-42 143.5 0.1 6.2e-42 143.2 0.1 1.1 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 ELR13593.1 - 9.1e-26 89.8 3.7 1.5e-25 89.1 3.7 1.4 1 0 0 1 1 1 1 DnaJ domain P2X_receptor PF00864.19 ELR13594.1 - 1.6e-22 80.1 0.2 3.6e-11 42.7 0.2 2.4 2 1 0 2 2 2 2 ATP P2X receptor Inhibitor_I9 PF05922.16 ELR13595.1 - 6.6e-05 23.5 0.0 0.00018 22.1 0.0 1.6 1 1 0 1 1 1 1 Peptidase inhibitor I9 YIF1 PF03878.15 ELR13596.1 - 2.8e-69 233.3 0.7 3.4e-69 233.0 0.7 1.0 1 0 0 1 1 1 1 YIF1 Yip1 PF04893.17 ELR13596.1 - 1.6e-05 24.7 10.3 2.7e-05 24.0 10.3 1.4 1 1 0 1 1 1 1 Yip1 domain NLE PF08154.12 ELR13597.1 - 0.017 15.7 0.3 0.12 12.9 0.0 2.2 2 0 0 2 2 2 0 NLE (NUC135) domain Pkinase PF00069.25 ELR13598.1 - 7.4e-19 68.1 0.0 9.9e-19 67.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR13598.1 - 0.0033 16.8 0.0 0.018 14.4 0.0 1.9 2 0 0 2 2 2 1 Protein tyrosine kinase RasGAP PF00616.19 ELR13599.1 - 5.3e-55 186.3 2.6 2.6e-54 184.1 0.0 2.6 2 0 0 2 2 2 1 GTPase-activator protein for Ras-like GTPase RasGAP_C PF03836.15 ELR13599.1 - 8.7e-20 71.3 7.4 8.7e-20 71.3 7.4 2.2 2 0 0 2 2 2 1 RasGAP C-terminus DUF5085 PF16895.5 ELR13599.1 - 3.9 7.8 7.9 0.89 9.9 0.2 3.3 4 0 0 4 4 4 0 Domain of unknown function (DUF5085) F-box-like PF12937.7 ELR13600.1 - 6.1e-08 32.4 0.2 1.5e-07 31.2 0.2 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ELR13600.1 - 5.9e-05 22.8 0.0 0.00011 22.0 0.0 1.4 1 0 0 1 1 1 1 F-box domain SPRY PF00622.28 ELR13600.1 - 0.041 14.0 0.0 0.093 12.8 0.0 1.6 1 0 0 1 1 1 0 SPRY domain TMEM144 PF07857.12 ELR13601.1 - 3.6e-96 322.1 15.6 5.6e-49 166.9 3.5 2.0 2 0 0 2 2 2 2 Transmembrane family, TMEM144 of transporters Sugar_transport PF06800.12 ELR13601.1 - 1.1e-10 41.4 17.5 7.7e-10 38.6 6.7 2.5 2 0 0 2 2 2 2 Sugar transport protein UNC-93 PF05978.16 ELR13602.1 - 7.2e-17 61.5 18.3 8.4e-15 54.8 10.1 3.2 2 1 0 2 2 2 2 Ion channel regulatory protein UNC-93 MFS_1 PF07690.16 ELR13602.1 - 4.6e-13 48.8 38.0 1.4e-06 27.5 17.9 2.6 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF3413 PF11893.8 ELR13602.1 - 0.79 8.8 6.8 0.82 8.8 0.6 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF3413) Trp_oprn_chp PF09534.10 ELR13602.1 - 5.1 6.8 8.5 0.16 11.7 1.0 2.3 3 1 0 3 3 3 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) HGTP_anticodon PF03129.20 ELR13603.1 - 6e-17 61.6 0.2 7e-17 61.4 0.2 1.1 1 0 0 1 1 1 1 Anticodon binding domain DUF4174 PF13778.6 ELR13603.1 - 0.08 13.4 0.2 0.32 11.5 0.1 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4174) tRNA-synt_2b PF00587.25 ELR13604.1 - 7.9e-34 117.2 0.0 1.5e-33 116.2 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) TGS PF02824.21 ELR13604.1 - 3.4e-16 59.0 0.0 1.4e-14 53.9 0.0 2.5 2 0 0 2 2 2 1 TGS domain tRNA_SAD PF07973.14 ELR13604.1 - 3.3e-13 49.5 0.0 1.1e-12 47.8 0.0 1.9 2 0 0 2 2 2 1 Threonyl and Alanyl tRNA synthetase second additional domain tRNA-synt_His PF13393.6 ELR13604.1 - 0.035 13.4 0.0 0.054 12.7 0.0 1.3 1 0 0 1 1 1 0 Histidyl-tRNA synthetase APH PF01636.23 ELR13605.1 - 9.1e-23 81.4 0.0 1.2e-22 81.0 0.0 1.1 1 0 0 1 1 1 1 Phosphotransferase enzyme family RhoGEF PF00621.20 ELR13606.1 - 1.1e-37 130.0 0.9 1.1e-37 130.0 0.9 2.9 3 1 0 3 3 3 1 RhoGEF domain CH PF00307.31 ELR13606.1 - 4.9e-10 39.6 0.4 2.1e-09 37.5 0.1 2.2 2 0 0 2 2 2 1 Calponin homology (CH) domain IQ_SEC7_PH PF16453.5 ELR13606.1 - 3.1e-05 24.0 0.0 6.4e-05 22.9 0.0 1.5 1 0 0 1 1 1 1 PH domain CDC24 PF06395.11 ELR13606.1 - 5.8e-05 23.3 0.1 0.00014 22.1 0.1 1.6 1 0 0 1 1 1 1 CDC24 Calponin PH PF00169.29 ELR13606.1 - 0.00011 22.7 0.1 0.00049 20.6 0.0 2.3 2 0 0 2 2 2 1 PH domain IQ PF00612.27 ELR13606.1 - 0.018 14.8 0.7 0.074 12.9 0.7 2.2 1 0 0 1 1 1 0 IQ calmodulin-binding motif DUF1488 PF07369.11 ELR13606.1 - 0.19 11.8 2.4 0.17 11.9 0.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1488) Rsm1 PF08600.10 ELR13608.1 - 0.12 12.5 1.2 11 6.3 0.1 2.2 2 0 0 2 2 2 0 Rsm1-like DSPc PF00782.20 ELR13609.1 - 2.1e-30 105.2 0.0 2.5e-30 105.0 0.0 1.1 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain MAM PF00629.23 ELR13610.1 - 1.2e-09 38.3 0.9 4.7e-09 36.4 0.9 1.8 1 1 0 1 1 1 1 MAM domain, meprin/A5/mu Asp5 PF17000.5 ELR13610.1 - 0.066 13.4 0.2 0.16 12.1 0.2 1.6 1 0 0 1 1 1 0 Accessory secretory protein Sec, Asp5 LRR_4 PF12799.7 ELR13612.1 - 9.4e-05 22.7 0.1 0.0049 17.2 0.0 1.8 1 1 1 2 2 2 2 Leucine Rich repeats (2 copies) Pkinase_Tyr PF07714.17 ELR13613.1 - 3.1e-127 423.2 0.0 1.3e-62 211.5 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 ELR13613.1 - 2.6e-109 364.6 0.0 4.5e-55 186.9 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain PBP_like_2 PF12849.7 ELR13613.1 - 5.1e-26 92.0 10.0 4.4e-17 62.7 0.5 2.3 2 0 0 2 2 2 2 PBP superfamily domain APH PF01636.23 ELR13613.1 - 3.3e-08 33.7 0.1 1.7e-05 24.9 0.0 2.6 2 0 0 2 2 2 2 Phosphotransferase enzyme family Guanylate_cyc PF00211.20 ELR13613.1 - 2.7e-05 23.8 0.0 5.1e-05 23.0 0.0 1.3 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain Haspin_kinase PF12330.8 ELR13613.1 - 0.00038 19.5 0.0 0.04 12.9 0.0 2.2 2 0 0 2 2 2 1 Haspin like kinase domain RIO1 PF01163.22 ELR13613.1 - 0.00086 19.0 0.5 1.4 8.5 0.1 2.4 2 0 0 2 2 2 2 RIO1 family Kinase-like PF14531.6 ELR13613.1 - 0.006 15.9 0.0 0.67 9.2 0.0 2.4 2 0 0 2 2 2 1 Kinase-like FTA2 PF13095.6 ELR13613.1 - 0.021 14.5 0.0 0.16 11.6 0.0 2.3 2 1 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 EGF_Tenascin PF18720.1 ELR13613.1 - 2.5 8.2 6.7 5.8 7.1 6.7 1.6 1 0 0 1 1 1 0 Tenascin EGF domain EGF_2 PF07974.13 ELR13613.1 - 3.2 8.2 8.7 6.3 7.3 8.7 1.5 1 0 0 1 1 1 0 EGF-like domain ABC_membrane PF00664.23 ELR13614.1 - 1.1e-37 130.2 9.0 1.4e-37 129.9 9.0 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 ELR13614.1 - 5e-35 121.0 0.1 2.7e-34 118.6 0.0 2.2 2 1 1 3 3 3 1 ABC transporter SMC_N PF02463.19 ELR13614.1 - 1.3e-07 31.3 1.0 1.6e-05 24.4 0.3 2.6 2 1 0 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 ELR13614.1 - 0.0004 20.8 0.1 0.0015 19.0 0.1 2.0 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 ELR13614.1 - 0.00058 20.1 0.1 0.0046 17.2 0.0 2.4 3 0 0 3 3 2 1 AAA domain DUF87 PF01935.17 ELR13614.1 - 0.0039 17.3 0.6 0.014 15.5 0.1 2.0 2 0 0 2 2 2 1 Helicase HerA, central domain AAA_29 PF13555.6 ELR13614.1 - 0.0054 16.4 0.3 0.031 14.0 0.2 2.3 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_24 PF13479.6 ELR13614.1 - 0.0059 16.4 0.1 0.014 15.1 0.0 1.8 2 0 0 2 2 2 1 AAA domain DUF4446 PF14584.6 ELR13614.1 - 0.0085 16.1 0.3 0.021 14.8 0.3 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF4446) ABC_ATPase PF09818.9 ELR13614.1 - 0.012 14.5 0.1 0.21 10.3 0.0 2.1 2 0 0 2 2 2 0 Predicted ATPase of the ABC class RsgA_GTPase PF03193.16 ELR13614.1 - 0.013 15.4 0.1 0.044 13.7 0.0 1.9 2 0 0 2 2 2 0 RsgA GTPase DEAD PF00270.29 ELR13614.1 - 0.015 15.1 0.1 0.045 13.5 0.1 1.8 1 1 0 1 1 1 0 DEAD/DEAH box helicase T2SSE PF00437.20 ELR13614.1 - 0.018 14.1 0.0 0.032 13.3 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_7 PF12775.7 ELR13614.1 - 0.024 14.1 0.0 0.049 13.1 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_33 PF13671.6 ELR13614.1 - 0.025 14.7 0.0 0.068 13.3 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_10 PF12846.7 ELR13614.1 - 0.03 13.2 0.0 0.06 12.2 0.0 1.4 1 0 0 1 1 1 0 AAA-like domain AAA_18 PF13238.6 ELR13614.1 - 0.033 14.7 0.0 0.099 13.2 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA PF00004.29 ELR13614.1 - 0.036 14.5 0.1 0.69 10.3 0.1 2.4 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_21 PF13304.6 ELR13614.1 - 0.038 13.8 0.0 0.14 11.9 0.0 1.8 1 1 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_25 PF13481.6 ELR13614.1 - 0.046 13.3 0.0 0.16 11.6 0.0 1.9 1 0 0 1 1 1 0 AAA domain AAA_23 PF13476.6 ELR13614.1 - 0.065 13.7 0.4 0.16 12.5 0.0 1.7 2 0 0 2 2 2 0 AAA domain Sigma54_activat PF00158.26 ELR13614.1 - 0.07 12.8 0.0 0.17 11.5 0.0 1.6 1 0 0 1 1 1 0 Sigma-54 interaction domain MMR_HSR1 PF01926.23 ELR13614.1 - 0.084 13.0 0.0 0.24 11.5 0.0 1.8 1 0 0 1 1 1 0 50S ribosome-binding GTPase HRI1 PF16815.5 ELR13614.1 - 0.088 12.5 0.0 0.17 11.6 0.0 1.4 1 0 0 1 1 1 0 Protein HRI1 Mg_chelatase PF01078.21 ELR13614.1 - 0.11 11.8 0.0 0.22 10.9 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_15 PF13175.6 ELR13614.1 - 0.14 11.8 0.1 0.27 10.9 0.0 1.5 2 0 0 2 2 1 0 AAA ATPase domain AAA_14 PF13173.6 ELR13614.1 - 0.16 12.0 0.1 1 9.4 0.0 2.5 3 0 0 3 3 2 0 AAA domain SbcCD_C PF13558.6 ELR13614.1 - 0.98 9.7 3.2 7.8 6.8 0.6 3.1 2 1 0 2 2 2 0 Putative exonuclease SbcCD, C subunit Clathrin PF00637.20 ELR13615.1 - 1.7e-24 86.4 8.7 2.2e-19 69.8 3.4 2.6 2 0 0 2 2 2 2 Region in Clathrin and VPS VPS11_C PF12451.8 ELR13615.1 - 1.7e-15 57.0 0.9 4.5e-15 55.6 0.9 1.8 1 0 0 1 1 1 1 Vacuolar protein sorting protein 11 C terminal zf-C3H2C3 PF17122.5 ELR13615.1 - 1.7e-05 24.7 8.7 4.5e-05 23.4 8.7 1.8 1 0 0 1 1 1 1 Zinc-finger zf-C3HC4_2 PF13923.6 ELR13615.1 - 0.00043 20.1 7.5 0.0014 18.4 7.5 2.0 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 ELR13615.1 - 0.011 16.0 7.8 0.051 13.9 7.8 2.3 1 0 0 1 1 1 0 Ring finger domain TPR_11 PF13414.6 ELR13615.1 - 0.034 13.8 0.0 0.2 11.3 0.0 2.5 2 0 0 2 2 2 0 TPR repeat zf-RING_5 PF14634.6 ELR13615.1 - 0.039 13.9 5.7 0.13 12.2 5.7 2.0 1 0 0 1 1 1 0 zinc-RING finger domain zf-rbx1 PF12678.7 ELR13615.1 - 0.18 12.1 7.0 0.28 11.5 5.7 2.1 2 0 0 2 2 2 0 RING-H2 zinc finger domain zf-RING_UBOX PF13445.6 ELR13615.1 - 0.38 10.8 5.7 1.7 8.7 5.7 2.2 1 0 0 1 1 1 0 RING-type zinc-finger Esterase_phd PF10503.9 ELR13616.1 - 1.8e-09 37.4 0.2 3.9e-09 36.3 0.2 1.5 1 0 0 1 1 1 1 Esterase PHB depolymerase Abhydrolase_2 PF02230.16 ELR13616.1 - 8.3e-06 25.8 0.0 0.001 18.9 0.0 2.2 2 0 0 2 2 2 2 Phospholipase/Carboxylesterase Esterase PF00756.20 ELR13616.1 - 0.00033 20.4 0.0 0.00052 19.7 0.0 1.4 1 0 0 1 1 1 1 Putative esterase Peptidase_S9 PF00326.21 ELR13616.1 - 0.02 14.4 0.0 2.9 7.3 0.0 2.3 1 1 1 2 2 2 0 Prolyl oligopeptidase family NUDIX PF00293.28 ELR13617.1 - 6.3e-11 42.4 0.0 1.6e-10 41.1 0.0 1.8 1 1 0 1 1 1 1 NUDIX domain WD40 PF00400.32 ELR13619.1 - 1.8e-31 107.7 31.0 1.4e-06 28.9 2.1 7.4 7 0 0 7 7 7 7 WD domain, G-beta repeat NLE PF08154.12 ELR13619.1 - 2.9e-18 66.1 1.0 5.4e-18 65.3 1.0 1.5 1 0 0 1 1 1 1 NLE (NUC135) domain ANAPC4_WD40 PF12894.7 ELR13619.1 - 3.4e-08 33.7 1.2 3.5e-06 27.2 0.2 3.3 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Frtz PF11768.8 ELR13619.1 - 0.083 11.2 0.0 0.17 10.2 0.0 1.4 2 0 0 2 2 2 0 WD repeat-containing and planar cell polarity effector protein Fritz Arf PF00025.21 ELR13620.1 - 3.2e-47 160.2 0.0 3.7e-47 160.0 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.22 ELR13620.1 - 2.5e-21 75.9 0.0 3e-21 75.7 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR13620.1 - 8.5e-18 64.7 0.0 1.2e-17 64.3 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Gtr1_RagA PF04670.12 ELR13620.1 - 4.8e-11 42.5 0.0 6e-11 42.1 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 ELR13620.1 - 2.5e-09 37.2 0.0 3.7e-09 36.7 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.10 ELR13620.1 - 3.9e-09 36.2 0.0 5e-09 35.8 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.20 ELR13620.1 - 4.9e-08 32.5 0.4 5.5e-05 22.5 0.0 2.3 1 1 1 2 2 2 2 G-protein alpha subunit GTP_EFTU PF00009.27 ELR13620.1 - 0.00017 21.2 0.0 0.0063 16.1 0.0 2.2 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain FeoB_N PF02421.18 ELR13620.1 - 0.013 15.0 2.3 0.14 11.7 2.3 2.2 1 1 0 1 1 1 0 Ferrous iron transport protein B Dynamin_N PF00350.23 ELR13620.1 - 0.02 14.9 0.2 1.8 8.6 0.2 2.2 1 1 1 2 2 2 0 Dynamin family AAA_7 PF12775.7 ELR13620.1 - 0.027 14.0 0.0 0.044 13.3 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region cobW PF02492.19 ELR13620.1 - 0.072 12.7 0.0 9.7 5.7 0.0 2.2 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Ras PF00071.22 ELR13622.1 - 1.3e-33 115.9 0.2 1.6e-33 115.6 0.2 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR13622.1 - 1.2e-05 25.5 0.0 2.6e-05 24.4 0.0 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1_Xtn PF16897.5 ELR13622.1 - 0.01 15.8 0.1 0.014 15.4 0.1 1.3 1 0 0 1 1 1 0 C-terminal region of MMR_HSR1 domain RsgA_GTPase PF03193.16 ELR13622.1 - 0.023 14.6 0.2 0.028 14.3 0.2 1.1 1 0 0 1 1 1 0 RsgA GTPase His_Phos_2 PF00328.22 ELR13622.1 - 0.049 13.0 0.0 0.054 12.8 0.0 1.1 1 0 0 1 1 1 0 Histidine phosphatase superfamily (branch 2) DUF1636 PF07845.11 ELR13622.1 - 0.13 12.7 0.3 0.27 11.7 0.2 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1636) LptF_LptG PF03739.14 ELR13623.1 - 0.0079 15.1 1.0 0.019 13.8 0.0 1.8 2 0 0 2 2 2 1 Lipopolysaccharide export system permease LptF/LptG MgtE PF01769.16 ELR13623.1 - 0.012 16.0 0.4 0.012 16.0 0.4 1.6 2 0 0 2 2 2 0 Divalent cation transporter ABC2_membrane PF01061.24 ELR13623.1 - 0.31 10.4 7.3 0.065 12.7 1.9 1.9 2 0 0 2 2 2 0 ABC-2 type transporter Abhydrolase_1 PF00561.20 ELR13624.1 - 5.8e-22 78.6 0.0 7.9e-16 58.5 0.0 2.1 2 0 0 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 ELR13624.1 - 1.1e-17 65.4 0.0 1.4e-17 65.1 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 ELR13624.1 - 2.9e-14 52.9 0.0 4.6e-14 52.3 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_3 PF07859.13 ELR13624.1 - 0.00067 19.6 0.1 0.0077 16.1 0.1 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold DLH PF01738.18 ELR13624.1 - 0.0058 16.2 0.0 0.058 12.9 0.0 2.2 2 0 0 2 2 2 1 Dienelactone hydrolase family Peptidase_S9 PF00326.21 ELR13624.1 - 0.1 12.0 0.0 0.68 9.4 0.0 2.1 2 0 0 2 2 2 0 Prolyl oligopeptidase family FSH1 PF03959.13 ELR13624.1 - 0.11 12.1 0.0 0.33 10.6 0.0 1.9 1 1 0 1 1 1 0 Serine hydrolase (FSH1) Abhydrolase_4 PF08386.10 ELR13624.1 - 0.12 12.4 0.0 0.29 11.3 0.0 1.6 1 0 0 1 1 1 0 TAP-like protein Pkinase PF00069.25 ELR13625.1 - 1e-42 146.3 0.0 5.1e-41 140.8 0.0 2.3 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR13625.1 - 8.8e-29 100.6 0.0 5.3e-27 94.7 0.0 2.7 2 1 0 2 2 2 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 ELR13625.1 - 1.9e-05 23.6 0.1 0.0017 17.2 0.0 2.1 2 0 0 2 2 2 1 Fungal protein kinase ABC1 PF03109.16 ELR13625.1 - 0.038 14.2 0.0 0.43 10.8 0.0 2.1 2 0 0 2 2 2 0 ABC1 family FliJ PF02050.16 ELR13625.1 - 0.66 10.2 7.5 1 9.6 7.5 1.2 1 0 0 1 1 1 0 Flagellar FliJ protein UPF0561 PF10573.9 ELR13625.1 - 0.67 10.1 5.8 1.3 9.1 5.8 1.4 1 0 0 1 1 1 0 Uncharacterised protein family UPF0561 CobT PF06213.12 ELR13625.1 - 4.8 6.5 12.6 7.9 5.8 12.6 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Spore_coat_CotO PF14153.6 ELR13625.1 - 8.6 6.2 11.7 13 5.6 11.7 1.2 1 0 0 1 1 1 0 Spore coat protein CotO PBP_sp32 PF07222.12 ELR13625.1 - 10 5.5 8.7 15 5.0 8.7 1.2 1 0 0 1 1 1 0 Proacrosin binding protein sp32 Glyco_transf_8 PF01501.20 ELR13626.1 - 8.9e-09 35.3 1.2 1.1e-06 28.4 1.2 2.2 1 1 0 1 1 1 1 Glycosyl transferase family 8 DUF3435 PF11917.8 ELR13627.1 - 0.079 11.9 1.1 0.11 11.4 1.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3435) FYVE_2 PF02318.16 ELR13627.1 - 0.22 11.8 8.5 1.1 9.5 0.2 2.6 3 0 0 3 3 3 0 FYVE-type zinc finger Cytochrome_C7 PF14522.6 ELR13627.1 - 2.8 8.0 12.7 2.6 8.1 0.4 3.0 2 1 0 2 2 2 0 Cytochrome c7 and related cytochrome c DZR PF12773.7 ELR13627.1 - 3.6 7.7 8.5 13 5.9 0.8 3.0 3 0 0 3 3 3 0 Double zinc ribbon Ribosomal_L35Ae PF01247.18 ELR13628.1 - 5.1e-42 141.9 0.1 5.8e-42 141.8 0.1 1.0 1 0 0 1 1 1 1 Ribosomal protein L35Ae RimM PF01782.18 ELR13628.1 - 0.015 15.5 0.0 1.2 9.4 0.0 2.2 2 0 0 2 2 2 0 RimM N-terminal domain ORC2 PF04084.14 ELR13629.1 - 1.2e-87 293.9 0.2 1.4e-87 293.7 0.2 1.0 1 0 0 1 1 1 1 Origin recognition complex subunit 2 Potyvirid-P3 PF13608.6 ELR13629.1 - 0.069 12.2 0.1 0.13 11.3 0.1 1.3 1 0 0 1 1 1 0 Protein P3 of Potyviral polyprotein Cation_efflux PF01545.21 ELR13630.1 - 1.4e-44 152.2 5.9 2e-44 151.7 5.9 1.2 1 0 0 1 1 1 1 Cation efflux family ZT_dimer PF16916.5 ELR13630.1 - 7.3e-22 77.3 5.7 1e-18 67.2 2.3 2.4 2 0 0 2 2 2 2 Dimerisation domain of Zinc Transporter Spore_YhcN_YlaJ PF09580.10 ELR13630.1 - 7.3 6.6 8.5 17 5.4 0.1 3.0 3 0 0 3 3 3 0 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) Pkinase PF00069.25 ELR13631.1 - 1.2e-70 237.9 0.0 1.6e-70 237.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR13631.1 - 1.6e-27 96.5 0.0 2.7e-27 95.7 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase FTA2 PF13095.6 ELR13631.1 - 0.00027 20.6 0.0 0.061 12.9 0.0 2.3 2 0 0 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 Kdo PF06293.14 ELR13631.1 - 0.0029 17.0 0.0 0.0046 16.3 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 ELR13631.1 - 0.0048 16.5 0.0 0.0083 15.7 0.0 1.3 1 0 0 1 1 1 1 RIO1 family Pkinase_fungal PF17667.1 ELR13631.1 - 0.0074 15.1 0.0 0.012 14.5 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 ELR13631.1 - 0.064 12.6 0.0 0.17 11.2 0.0 1.6 2 0 0 2 2 2 0 Kinase-like DUF2340 PF10209.9 ELR13632.1 - 2.3e-14 53.9 0.6 1e-09 38.9 0.0 2.0 1 1 1 2 2 2 2 Uncharacterized conserved protein (DUF2340) PH PF00169.29 ELR13633.1 - 6.4e-19 68.4 0.1 1.4e-18 67.3 0.1 1.6 1 0 0 1 1 1 1 PH domain FHA PF00498.26 ELR13633.1 - 2e-14 53.7 0.2 3.8e-14 52.8 0.2 1.5 1 0 0 1 1 1 1 FHA domain Yop-YscD_cpl PF16697.5 ELR13633.1 - 1.1e-10 41.7 0.0 2.8e-10 40.4 0.0 1.7 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain PH_8 PF15409.6 ELR13633.1 - 1.8e-06 28.1 0.6 5e-05 23.5 0.2 2.4 2 0 0 2 2 2 1 Pleckstrin homology domain PH_13 PF16652.5 ELR13633.1 - 2.7e-05 24.0 0.2 7e-05 22.7 0.2 1.6 1 0 0 1 1 1 1 Pleckstrin homology domain SOBP PF15279.6 ELR13633.1 - 0.00036 21.2 23.8 0.00036 21.2 23.8 3.8 4 1 1 5 5 4 1 Sine oculis-binding protein PH_11 PF15413.6 ELR13633.1 - 0.0038 17.6 3.5 0.04 14.3 3.5 2.6 1 1 0 1 1 1 1 Pleckstrin homology domain PH_9 PF15410.6 ELR13633.1 - 0.031 14.6 0.8 0.19 12.1 0.8 2.2 1 1 0 1 1 1 0 Pleckstrin homology domain PH_2 PF08458.10 ELR13633.1 - 0.051 13.9 0.0 0.11 12.9 0.0 1.5 1 0 0 1 1 1 0 Plant pleckstrin homology-like region Mcp5_PH PF12814.7 ELR13633.1 - 0.084 13.0 0.0 0.18 11.9 0.0 1.6 1 0 0 1 1 1 0 Meiotic cell cortex C-terminal pleckstrin homology PH_6 PF15406.6 ELR13633.1 - 0.15 12.4 1.5 0.35 11.2 0.0 2.5 2 0 0 2 2 1 0 Pleckstrin homology domain Ras PF00071.22 ELR13634.1 - 7.2e-58 194.8 0.2 8.4e-58 194.5 0.2 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR13634.1 - 4.3e-20 72.1 0.0 7.4e-20 71.4 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR13634.1 - 5.7e-08 32.4 0.0 7e-08 32.1 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 ELR13634.1 - 0.00022 21.2 0.1 0.072 13.0 0.2 2.2 2 0 0 2 2 2 2 RsgA GTPase GTP_EFTU PF00009.27 ELR13634.1 - 0.00091 18.8 0.2 0.0024 17.4 0.2 1.8 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1_Xtn PF16897.5 ELR13634.1 - 0.021 14.8 0.1 0.033 14.2 0.1 1.3 1 0 0 1 1 1 0 C-terminal region of MMR_HSR1 domain ATP_bind_1 PF03029.17 ELR13634.1 - 0.022 14.5 2.4 0.034 13.9 0.0 2.0 1 1 1 2 2 2 0 Conserved hypothetical ATP binding protein DUF1636 PF07845.11 ELR13634.1 - 0.16 12.4 0.5 0.56 10.7 0.2 1.9 2 1 1 3 3 3 0 Protein of unknown function (DUF1636) AlkA_N PF06029.11 ELR13634.1 - 0.17 12.2 0.0 0.36 11.1 0.0 1.5 1 0 0 1 1 1 0 AlkA N-terminal domain MORN PF02493.20 ELR13635.1 - 1.2e-44 147.5 95.2 2.1e-07 30.4 1.0 11.1 10 2 0 10 10 10 8 MORN repeat F-box-like PF12937.7 ELR13635.1 - 6.2e-06 26.0 0.0 1.2e-05 25.0 0.0 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ELR13635.1 - 0.00011 22.0 0.2 0.00021 21.1 0.2 1.4 1 0 0 1 1 1 1 F-box domain Chorion_2 PF03964.15 ELR13636.1 - 1.8 9.5 5.1 3.7 8.5 4.7 1.7 2 0 0 2 2 2 0 Chorion family 2 SR-25 PF10500.9 ELR13636.1 - 3 7.4 12.3 5.5 6.5 12.3 1.4 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein UCH PF00443.29 ELR13637.1 - 1.8e-52 178.4 0.1 2.6e-52 177.9 0.1 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 ELR13637.1 - 9.6e-29 101.0 0.1 5.3e-28 98.5 0.1 2.2 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Cullin_binding PF03556.15 ELR13637.1 - 1.1e-14 54.9 3.3 1.7e-14 54.3 1.7 2.2 2 0 0 2 2 2 1 Cullin binding RNA_pol_Rpc82 PF05645.13 ELR13637.1 - 0.35 10.6 3.0 0.7 9.6 3.0 1.4 1 0 0 1 1 1 0 RNA polymerase III subunit RPC82 DZR PF12773.7 ELR13637.1 - 0.48 10.5 3.9 14 5.8 1.9 2.7 2 1 0 2 2 2 0 Double zinc ribbon zf-RanBP PF00641.18 ELR13637.1 - 2.9 7.3 13.5 0.092 12.1 1.0 3.2 3 0 0 3 3 3 0 Zn-finger in Ran binding protein and others START PF01852.19 ELR13638.1 - 8.1e-17 61.3 0.0 1.1e-16 60.9 0.0 1.1 1 0 0 1 1 1 1 START domain Glyco_hydro_31 PF01055.26 ELR13639.1 - 3e-67 227.7 6.7 4.3e-67 227.2 6.7 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 DUF5110 PF17137.4 ELR13639.1 - 1.1e-14 54.4 0.0 2.5e-14 53.3 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF5110) Trefoil PF00088.18 ELR13639.1 - 6.5e-07 29.1 2.8 1.2e-06 28.3 2.8 1.4 1 0 0 1 1 1 1 Trefoil (P-type) domain DUF4968 PF16338.5 ELR13639.1 - 0.0001 22.6 0.0 0.00022 21.5 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4968) DUF1746 PF08508.10 ELR13640.1 - 1.3e-10 41.6 8.2 4.6e-09 36.6 8.2 2.1 1 1 0 1 1 1 1 Fungal domain of unknown function (DUF1746) DUF5592 PF17332.2 ELR13640.1 - 0.15 12.6 0.4 0.15 12.6 0.4 1.8 2 0 0 2 2 2 0 Family of unknown function (DUF5592) Pkinase PF00069.25 ELR13641.1 - 5.6e-73 245.5 0.0 8e-73 245.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR13641.1 - 4e-49 167.2 0.0 5.9e-49 166.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ELR13641.1 - 5.3e-07 29.2 0.0 8.9e-07 28.5 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 ELR13641.1 - 0.0024 16.9 0.0 0.0044 16.0 0.0 1.3 1 0 0 1 1 1 1 Haspin like kinase domain Pkinase_fungal PF17667.1 ELR13641.1 - 0.15 10.8 0.0 0.15 10.8 0.0 2.3 2 1 0 2 2 2 0 Fungal protein kinase Radial_spoke_3 PF06098.11 ELR13642.1 - 0.032 13.5 3.2 0.036 13.3 3.2 1.2 1 0 0 1 1 1 0 Radial spoke protein 3 DUF4710 PF15828.5 ELR13642.1 - 0.21 11.7 3.8 0.31 11.2 3.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4710) MMS1_N PF10433.9 ELR13643.1 - 1e-158 529.0 0.0 1.7e-158 528.3 0.0 1.3 1 0 0 1 1 1 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term CPSF_A PF03178.15 ELR13643.1 - 3.8e-102 341.9 0.0 4.1e-100 335.2 0.0 2.9 3 0 0 3 3 3 1 CPSF A subunit region Phage_TAC_14 PF16462.5 ELR13643.1 - 0.16 12.2 0.0 0.45 10.8 0.0 1.7 1 0 0 1 1 1 0 Phage tail assembly chaperone protein, TAC GCN5L1 PF06320.13 ELR13645.1 - 4.6e-41 139.5 9.6 5.3e-41 139.3 9.6 1.0 1 0 0 1 1 1 1 GCN5-like protein 1 (GCN5L1) DDE_Tnp_1_6 PF13751.6 ELR13645.1 - 0.11 12.7 3.7 0.14 12.4 0.9 1.9 1 1 1 2 2 2 0 Transposase DDE domain Seryl_tRNA_N PF02403.22 ELR13645.1 - 1 9.6 6.8 1.3 9.3 4.6 2.0 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain ACPS PF01648.20 ELR13646.1 - 8.2e-16 58.2 0.4 4.5e-15 55.8 0.0 2.2 3 0 0 3 3 3 1 4'-phosphopantetheinyl transferase superfamily TIM PF00121.18 ELR13647.1 - 0.00063 19.2 0.0 0.0015 18.0 0.0 1.6 1 1 1 2 2 2 1 Triosephosphate isomerase FMN_dh PF01070.18 ELR13647.1 - 0.013 14.5 1.3 0.026 13.6 0.6 1.8 2 0 0 2 2 2 0 FMN-dependent dehydrogenase NMO PF03060.15 ELR13647.1 - 0.021 14.2 0.9 0.035 13.5 0.9 1.5 1 1 0 1 1 1 0 Nitronate monooxygenase His_biosynth PF00977.21 ELR13647.1 - 0.046 13.2 0.0 0.075 12.5 0.0 1.3 1 0 0 1 1 1 0 Histidine biosynthesis protein LPD11 PF18824.1 ELR13647.1 - 0.22 11.6 0.0 0.4 10.8 0.0 1.4 1 0 0 1 1 1 0 Large polyvalent protein-associated domain 11 Sacchrp_dh_NADP PF03435.18 ELR13648.1 - 3.6e-14 53.1 0.5 5.4e-14 52.6 0.5 1.3 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain NAD_binding_10 PF13460.6 ELR13648.1 - 0.00058 19.8 4.9 0.0015 18.4 4.9 1.7 1 1 0 1 1 1 1 NAD(P)H-binding TMP_2 PF06791.13 ELR13648.1 - 0.00066 19.4 6.9 0.0019 17.9 0.3 2.3 2 0 0 2 2 2 2 Prophage tail length tape measure protein KR PF08659.10 ELR13648.1 - 0.017 15.1 0.6 0.036 14.0 0.6 1.5 1 0 0 1 1 1 0 KR domain NmrA PF05368.13 ELR13648.1 - 0.044 13.3 1.2 0.084 12.4 1.2 1.5 1 0 0 1 1 1 0 NmrA-like family RasGAP PF00616.19 ELR13649.1 - 3.9e-30 105.1 0.0 2.6e-20 73.0 0.0 2.5 1 1 1 2 2 2 2 GTPase-activator protein for Ras-like GTPase DEP PF00610.21 ELR13649.1 - 4.2e-28 97.2 0.3 5.2e-19 68.1 0.1 2.6 2 0 0 2 2 2 2 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) C2 PF00168.30 ELR13649.1 - 0.0001 22.5 0.0 0.00018 21.8 0.0 1.4 1 0 0 1 1 1 1 C2 domain F-box-like PF12937.7 ELR13650.1 - 2.6e-05 24.0 0.1 5.5e-05 23.0 0.1 1.5 1 0 0 1 1 1 1 F-box-like FRG1 PF06229.12 ELR13650.1 - 0.0012 18.5 0.0 0.0012 18.5 0.0 1.9 2 0 0 2 2 2 1 FRG1-like domain F-box PF00646.33 ELR13650.1 - 0.0036 17.1 0.7 0.0085 16.0 0.3 1.8 2 0 0 2 2 2 1 F-box domain MctB PF11382.8 ELR13650.1 - 0.062 13.0 3.8 0.11 12.2 3.8 1.4 1 0 0 1 1 1 0 Copper transport outer membrane protein, MctB Kelch_1 PF01344.25 ELR13651.1 - 1.5e-42 142.9 5.2 4.1e-08 32.7 0.1 6.1 6 0 0 6 6 6 6 Kelch motif Kelch_4 PF13418.6 ELR13651.1 - 7.8e-40 134.7 16.3 1.7e-08 34.3 0.0 6.1 6 0 0 6 6 6 6 Galactose oxidase, central domain Kelch_5 PF13854.6 ELR13651.1 - 4.2e-36 122.4 8.2 2e-06 27.6 0.0 6.2 6 0 0 6 6 6 6 Kelch motif Kelch_3 PF13415.6 ELR13651.1 - 5.4e-33 112.7 18.6 1.2e-06 28.6 0.0 7.1 7 0 0 7 7 7 6 Galactose oxidase, central domain Kelch_2 PF07646.15 ELR13651.1 - 5.2e-32 108.6 8.2 4.6e-07 29.6 0.1 6.1 6 0 0 6 6 6 6 Kelch motif Kelch_6 PF13964.6 ELR13651.1 - 5.7e-31 105.8 12.2 1.4e-05 25.2 0.0 6.1 4 2 2 6 6 6 6 Kelch motif zf-CCCH_3 PF15663.5 ELR13652.1 - 1e-05 25.7 6.0 0.00038 20.7 6.0 2.4 1 1 0 1 1 1 1 Zinc-finger containing family TetR_C_1 PF02909.17 ELR13652.1 - 0.31 10.9 3.5 0.83 9.5 0.1 2.3 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain Neur_chan_memb PF02932.16 ELR13652.1 - 2.3 8.2 4.4 3.8 7.5 4.4 1.4 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region SRP-alpha_N PF04086.13 ELR13652.1 - 4.4 7.1 22.5 7.6 6.4 22.5 1.4 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal zf_CCCH_4 PF18345.1 ELR13652.1 - 9.6 6.4 10.9 0.21 11.7 2.6 2.4 3 0 0 3 3 3 0 Zinc finger domain Dynein_light PF01221.18 ELR13653.1 - 3.4e-36 123.4 0.7 3.7e-36 123.3 0.7 1.0 1 0 0 1 1 1 1 Dynein light chain type 1 R3H PF01424.22 ELR13654.1 - 7.3e-12 45.1 0.2 1.7e-11 43.9 0.2 1.7 1 0 0 1 1 1 1 R3H domain TMEM171 PF15471.6 ELR13654.1 - 0.11 11.4 0.1 0.16 10.9 0.1 1.4 1 0 0 1 1 1 0 Transmembrane protein family 171 Activator_LAG-3 PF11498.8 ELR13654.1 - 0.59 9.0 11.1 0.059 12.3 4.6 2.0 2 0 0 2 2 2 0 Transcriptional activator LAG-3 Methyltransf_11 PF08241.12 ELR13656.1 - 0.033 14.8 0.0 0.065 13.9 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain AstE_AspA PF04952.14 ELR13657.1 - 1.4e-39 136.0 0.0 1.9e-39 135.5 0.0 1.2 1 0 0 1 1 1 1 Succinylglutamate desuccinylase / Aspartoacylase family SPX PF03105.19 ELR13657.1 - 2.5e-09 37.6 10.6 4.9e-07 30.0 0.7 3.2 1 1 2 3 3 3 3 SPX domain kleA_kleC PF17383.2 ELR13657.1 - 0.0046 17.3 0.2 0.04 14.2 0.0 2.2 2 0 0 2 2 2 1 Uncharacterized KorC regulated protein A Phasin PF05597.11 ELR13657.1 - 0.088 12.8 0.4 0.24 11.4 0.0 1.8 2 0 0 2 2 2 0 Poly(hydroxyalcanoate) granule associated protein (phasin) DUF573 PF04504.14 ELR13657.1 - 0.14 12.8 0.6 0.41 11.3 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function, DUF573 MHB PF16525.5 ELR13657.1 - 0.21 11.9 0.2 1.8 8.9 0.0 2.3 2 0 0 2 2 2 0 Haemophore, haem-binding DUF2973 PF11189.8 ELR13658.1 - 0.014 15.5 0.0 0.035 14.2 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2973) ATP-grasp PF02222.22 ELR13658.1 - 0.014 15.0 0.0 0.026 14.1 0.0 1.3 1 0 0 1 1 1 0 ATP-grasp domain REC114-like PF15165.6 ELR13659.1 - 0.002 18.0 0.0 0.0027 17.5 0.0 1.2 1 0 0 1 1 1 1 Meiotic recombination protein REC114-like Period_C PF12114.8 ELR13659.1 - 0.093 12.3 1.3 0.12 12.0 1.3 1.1 1 0 0 1 1 1 0 Period protein 2/3C-terminal region AAA_28 PF13521.6 ELR13660.1 - 0.0041 17.4 0.0 0.011 15.9 0.0 1.8 2 0 0 2 2 2 1 AAA domain Dynamin_N PF00350.23 ELR13660.1 - 0.01 15.9 0.0 0.016 15.3 0.0 1.2 1 0 0 1 1 1 0 Dynamin family cobW PF02492.19 ELR13660.1 - 0.014 15.0 0.5 6.6 6.3 0.1 3.0 2 1 1 3 3 3 0 CobW/HypB/UreG, nucleotide-binding domain AAA_16 PF13191.6 ELR13660.1 - 0.017 15.6 0.1 0.04 14.3 0.0 1.6 2 0 0 2 2 2 0 AAA ATPase domain TniB PF05621.11 ELR13660.1 - 0.019 14.4 0.0 0.03 13.7 0.0 1.2 1 0 0 1 1 1 0 Bacterial TniB protein MMR_HSR1 PF01926.23 ELR13660.1 - 0.079 13.0 0.1 0.34 11.0 0.1 2.0 1 1 0 1 1 1 0 50S ribosome-binding GTPase DUF815 PF05673.13 ELR13660.1 - 0.1 11.8 0.0 0.16 11.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF815) G-alpha PF00503.20 ELR13660.1 - 0.11 11.6 0.0 1.3 8.1 0.0 2.0 2 0 0 2 2 2 0 G-protein alpha subunit AAA_29 PF13555.6 ELR13660.1 - 0.13 12.0 0.0 0.29 10.9 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_14 PF13173.6 ELR13660.1 - 0.2 11.7 0.0 0.35 10.9 0.0 1.3 1 0 0 1 1 1 0 AAA domain Actin PF00022.19 ELR13661.1 - 1.3e-154 514.7 0.0 4.2e-154 513.1 0.0 1.6 1 1 0 1 1 1 1 Actin Peptidase_M20 PF01546.28 ELR13662.1 - 1.3e-26 93.6 0.1 4.6e-26 91.8 0.1 1.9 1 1 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 ELR13662.1 - 2.6e-10 40.2 0.0 6.3e-10 38.9 0.0 1.7 1 0 0 1 1 1 1 Peptidase dimerisation domain LRR_6 PF13516.6 ELR13663.1 - 1e-49 162.4 49.9 0.00022 21.0 0.1 17.3 17 0 0 17 17 17 12 Leucine Rich repeat LRR_1 PF00560.33 ELR13663.1 - 5.1e-09 35.4 4.8 9.5 7.2 0.0 11.5 14 0 0 14 14 14 1 Leucine Rich Repeat LRR_4 PF12799.7 ELR13663.1 - 9e-05 22.8 31.3 0.11 13.0 0.1 9.2 8 2 4 12 12 12 2 Leucine Rich repeats (2 copies) PIN_11 PF18479.1 ELR13663.1 - 0.0018 18.4 0.0 0.11 12.6 0.0 2.4 2 0 0 2 2 2 1 PIN like domain Microtub_bind PF13931.6 ELR13663.1 - 0.057 13.8 0.8 0.22 11.9 0.8 1.9 1 0 0 1 1 1 0 Kinesin-associated microtubule-binding PIN7 PF18475.1 ELR13663.1 - 0.1 13.2 0.0 0.92 10.2 0.0 2.3 2 0 0 2 2 2 0 PIN domain LRR_8 PF13855.6 ELR13663.1 - 0.17 11.6 42.4 0.21 11.4 3.4 10.4 9 1 2 11 11 11 0 Leucine rich repeat Asn_synthase PF00733.21 ELR13664.1 - 1.8e-97 327.2 0.4 1e-56 193.2 0.0 2.1 1 1 1 2 2 2 2 Asparagine synthase GATase_7 PF13537.6 ELR13664.1 - 9.7e-38 128.9 0.0 1.7e-37 128.1 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_6 PF13522.6 ELR13664.1 - 2.6e-28 98.9 0.0 4.5e-28 98.1 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase domain DUF3700 PF12481.8 ELR13664.1 - 6.9e-10 38.8 0.0 1.3e-09 37.9 0.0 1.3 1 0 0 1 1 1 1 Aluminium induced protein NAD_synthase PF02540.17 ELR13664.1 - 0.0069 15.5 0.0 0.061 12.4 0.0 2.0 2 0 0 2 2 2 1 NAD synthase DUF1933 PF09147.10 ELR13664.1 - 0.19 11.3 0.0 0.32 10.6 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1933) Pam16 PF03656.13 ELR13665.1 - 5.8e-23 81.3 0.5 1.5e-21 76.7 0.5 2.0 1 1 0 1 1 1 1 Pam16 GTP_EFTU PF00009.27 ELR13666.1 - 6.3e-28 97.6 0.1 3.4e-26 92.0 0.1 2.4 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain IF-2 PF11987.8 ELR13666.1 - 4.8e-19 68.4 0.1 9.9e-19 67.4 0.1 1.5 1 0 0 1 1 1 1 Translation-initiation factor 2 MMR_HSR1 PF01926.23 ELR13666.1 - 8.2e-09 35.5 0.0 2.6e-08 34.0 0.0 1.9 2 0 0 2 2 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 ELR13666.1 - 0.0011 18.9 0.3 0.77 9.7 0.0 3.0 2 1 1 3 3 3 1 RsgA GTPase ABC_ATPase PF09818.9 ELR13666.1 - 0.0011 17.8 0.2 0.002 17.0 0.2 1.3 1 0 0 1 1 1 1 Predicted ATPase of the ABC class SRPRB PF09439.10 ELR13666.1 - 0.0021 17.5 0.0 0.0051 16.3 0.0 1.6 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit Roc PF08477.13 ELR13666.1 - 0.0025 18.0 0.0 0.0086 16.3 0.0 1.8 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Dynamin_N PF00350.23 ELR13666.1 - 0.0031 17.6 1.6 0.018 15.1 0.0 2.6 2 1 0 2 2 2 1 Dynamin family Nop14 PF04147.12 ELR13666.1 - 0.0072 14.6 3.0 0.0092 14.3 3.0 1.1 1 0 0 1 1 1 1 Nop14-like family IF2_N PF04760.15 ELR13666.1 - 0.014 15.2 0.0 0.029 14.2 0.0 1.6 1 0 0 1 1 1 0 Translation initiation factor IF-2, N-terminal region PduV-EutP PF10662.9 ELR13666.1 - 0.026 14.3 0.1 0.16 11.7 0.0 2.3 2 1 0 2 2 1 0 Ethanolamine utilisation - propanediol utilisation ATP_bind_1 PF03029.17 ELR13666.1 - 0.093 12.5 0.0 0.74 9.5 0.0 2.3 1 1 1 2 2 2 0 Conserved hypothetical ATP binding protein AAA_29 PF13555.6 ELR13666.1 - 0.1 12.4 0.0 0.24 11.1 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain FeoB_N PF02421.18 ELR13666.1 - 0.12 11.9 0.1 2.4 7.7 0.1 2.7 1 1 0 1 1 1 0 Ferrous iron transport protein B DUF4611 PF15387.6 ELR13666.1 - 0.2 11.9 7.0 0.46 10.7 7.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4611) RXT2_N PF08595.11 ELR13666.1 - 1.1 9.3 6.7 2.1 8.3 6.7 1.4 1 0 0 1 1 1 0 RXT2-like, N-terminal Sporozoite_P67 PF05642.11 ELR13666.1 - 1.2 7.1 5.5 1.8 6.5 5.5 1.2 1 0 0 1 1 1 0 Sporozoite P67 surface antigen CENP-B_dimeris PF09026.10 ELR13666.1 - 5.8 7.4 13.8 12 6.4 13.8 1.4 1 0 0 1 1 1 0 Centromere protein B dimerisation domain NOA36 PF06524.12 ELR13666.1 - 8.8 5.6 13.4 13 5.0 13.4 1.2 1 0 0 1 1 1 0 NOA36 protein Myb_DNA-bind_7 PF15963.5 ELR13667.1 - 4.4e-24 84.2 2.1 7.9e-24 83.4 2.1 1.4 1 0 0 1 1 1 1 Myb DNA-binding like Myb_DNA-binding PF00249.31 ELR13667.1 - 2.7e-08 33.9 0.0 5.9e-08 32.8 0.0 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 ELR13667.1 - 0.0049 17.1 0.4 0.0087 16.3 0.4 1.5 1 0 0 1 1 1 1 Myb-like DNA-binding domain SANT_DAMP1_like PF16282.5 ELR13667.1 - 0.063 13.5 0.7 0.13 12.5 0.7 1.4 1 0 0 1 1 1 0 SANT/Myb-like domain of DAMP1 SOG2 PF10428.9 ELR13667.1 - 1.6 7.8 13.8 1.9 7.6 13.8 1.2 1 0 0 1 1 1 0 RAM signalling pathway protein AMP-binding PF00501.28 ELR13668.1 - 1.8e-69 234.4 0.0 2.3e-64 217.6 0.0 3.0 1 1 1 2 2 2 2 AMP-binding enzyme UQ_con PF00179.26 ELR13669.1 - 5.1e-40 136.4 0.1 1.4e-18 66.9 0.0 2.8 2 1 0 2 2 2 2 Ubiquitin-conjugating enzyme UDPGP PF01704.18 ELR13670.1 - 2.4e-41 141.8 0.0 3.5e-41 141.2 0.0 1.2 1 0 0 1 1 1 1 UTP--glucose-1-phosphate uridylyltransferase PGM_PMM_I PF02878.16 ELR13670.1 - 1.9e-38 131.3 0.0 4.3e-38 130.1 0.0 1.6 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_II PF02879.16 ELR13670.1 - 4.4e-23 81.9 0.0 2.8e-22 79.3 0.0 2.4 2 0 0 2 2 2 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II SIS PF01380.22 ELR13670.1 - 3.3e-21 75.5 1.1 7.5e-21 74.4 1.1 1.6 1 0 0 1 1 1 1 SIS domain PGM_PMM_III PF02880.16 ELR13670.1 - 7.9e-12 45.4 0.0 1.5e-11 44.5 0.0 1.5 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III NTP_transf_3 PF12804.7 ELR13670.1 - 0.0024 18.2 0.0 0.037 14.4 0.0 2.7 2 0 0 2 2 2 1 MobA-like NTP transferase domain SIS_2 PF13580.6 ELR13670.1 - 0.0031 17.5 1.7 0.29 11.1 0.2 2.8 1 1 1 2 2 2 1 SIS domain PGM_PMM_IV PF00408.20 ELR13670.1 - 0.0061 16.7 0.0 0.019 15.1 0.0 1.8 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain RCC1 PF00415.18 ELR13671.1 - 2.3e-49 165.8 17.9 1.7e-11 44.5 0.0 6.2 6 0 0 6 6 6 6 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 ELR13671.1 - 2.8e-21 74.8 26.9 2.2e-10 40.1 3.5 5.2 5 0 0 5 5 5 5 Regulator of chromosome condensation (RCC1) repeat DUF4213 PF13938.6 ELR13671.1 - 0.0035 17.5 0.0 5.2 7.4 0.0 3.5 3 0 0 3 3 3 1 Putative heavy-metal chelation Alpha_L_fucos PF01120.17 ELR13672.1 - 1.9e-105 353.2 5.6 5.3e-63 213.6 0.2 2.2 2 0 0 2 2 2 2 Alpha-L-fucosidase Fucosidase_C PF16757.5 ELR13672.1 - 1.2e-13 51.4 0.4 2.3e-13 50.5 0.4 1.5 1 0 0 1 1 1 1 Alpha-L-fucosidase C-terminal domain DUF3847 PF12958.7 ELR13673.1 - 0.098 12.8 0.1 0.1 12.7 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3847) NOG1_N PF17835.1 ELR13674.1 - 2.5e-55 186.8 0.5 4.9e-55 185.9 0.5 1.5 1 0 0 1 1 1 1 NOG1 N-terminal helical domain NOGCT PF08155.11 ELR13674.1 - 8.1e-17 60.9 3.2 8.1e-17 60.9 3.2 2.2 2 1 0 2 2 2 1 NOGCT (NUC087) domain MMR_HSR1 PF01926.23 ELR13674.1 - 3.5e-09 36.7 0.0 7.3e-09 35.7 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 ELR13674.1 - 0.0003 20.4 0.0 0.00052 19.6 0.0 1.4 1 0 0 1 1 1 1 Ferrous iron transport protein B AAA_18 PF13238.6 ELR13674.1 - 0.00071 20.1 0.2 0.16 12.5 0.0 3.3 2 1 0 3 3 3 1 AAA domain AAA_16 PF13191.6 ELR13674.1 - 0.0086 16.5 0.0 0.019 15.4 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain Dynamin_N PF00350.23 ELR13674.1 - 0.16 12.0 0.0 0.32 11.0 0.0 1.6 1 0 0 1 1 1 0 Dynamin family RsgA_GTPase PF03193.16 ELR13674.1 - 0.17 11.8 0.0 0.33 10.9 0.0 1.5 1 0 0 1 1 1 0 RsgA GTPase RRN3 PF05327.11 ELR13676.1 - 1.5e-92 310.9 16.6 8.6e-66 222.6 5.4 2.8 1 1 1 2 2 2 2 RNA polymerase I specific transcription initiation factor RRN3 AA_permease_2 PF13520.6 ELR13678.1 - 1.5e-44 152.5 44.9 2e-42 145.5 44.9 2.1 1 1 0 1 1 1 1 Amino acid permease Sec62 PF03839.16 ELR13678.1 - 1.3 8.4 4.2 3.2 7.2 4.2 1.5 1 0 0 1 1 1 0 Translocation protein Sec62 Methyltransf_16 PF10294.9 ELR13679.1 - 1.3e-15 57.5 0.1 6.2e-07 29.3 0.0 2.1 1 1 1 2 2 2 2 Lysine methyltransferase MTS PF05175.14 ELR13679.1 - 0.091 12.3 0.2 0.33 10.5 0.1 1.8 2 0 0 2 2 2 0 Methyltransferase small domain Methyltransf_31 PF13847.6 ELR13679.1 - 0.3 10.9 1.5 45 3.8 0.1 3.0 2 1 1 3 3 3 0 Methyltransferase domain WRNPLPNID PF15017.6 ELR13681.1 - 2 9.4 6.2 1.8 9.5 5.4 1.3 1 1 0 1 1 1 0 Putative WW-binding domain and destruction box Rubis-subs-bind PF09273.11 ELR13682.1 - 1.5e-13 51.5 0.9 3.9e-13 50.2 0.9 1.7 1 0 0 1 1 1 1 Rubisco LSMT substrate-binding SET PF00856.28 ELR13682.1 - 4e-10 40.4 0.0 8.3e-10 39.3 0.0 1.5 1 0 0 1 1 1 1 SET domain FRB_dom PF08771.11 ELR13682.1 - 0.0014 19.0 0.3 0.055 13.9 0.1 2.8 3 0 0 3 3 3 1 FKBP12-rapamycin binding domain Acetyltransf_1 PF00583.25 ELR13683.1 - 2.5e-05 24.5 0.0 4.6e-05 23.6 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 ELR13683.1 - 4.6e-05 23.8 0.0 0.00011 22.6 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 ELR13683.1 - 0.0096 15.9 0.0 0.026 14.5 0.0 1.7 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_10 PF13673.7 ELR13683.1 - 0.014 15.3 0.0 0.031 14.2 0.0 1.6 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 ELR13683.1 - 0.035 14.2 0.1 0.089 12.9 0.0 1.6 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 ELR13683.1 - 0.038 14.1 0.0 0.073 13.2 0.0 1.4 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase CsbD PF05532.12 ELR13685.1 - 0.0011 18.8 2.4 0.0019 18.0 2.4 1.3 1 0 0 1 1 1 1 CsbD-like PIGA PF08288.12 ELR13685.1 - 6.2 7.5 8.0 23 5.7 0.9 2.5 2 0 0 2 2 2 0 PIGA (GPI anchor biosynthesis) Kelch_3 PF13415.6 ELR13687.1 - 1.5e-26 92.1 5.7 8.1e-09 35.6 0.1 4.7 4 0 0 4 4 4 4 Galactose oxidase, central domain Kelch_4 PF13418.6 ELR13687.1 - 5.5e-26 90.3 3.0 3.3e-07 30.2 0.1 4.6 4 0 0 4 4 4 4 Galactose oxidase, central domain Kelch_6 PF13964.6 ELR13687.1 - 8.4e-21 73.5 2.2 5e-07 29.8 0.0 4.5 4 0 0 4 4 4 4 Kelch motif Kelch_5 PF13854.6 ELR13687.1 - 1.3e-20 72.9 0.9 3e-08 33.5 0.0 4.6 4 0 0 4 4 4 4 Kelch motif BTB PF00651.31 ELR13687.1 - 1.9e-19 69.9 0.0 7.1e-09 35.9 0.0 3.1 4 0 0 4 4 4 2 BTB/POZ domain Kelch_1 PF01344.25 ELR13687.1 - 4.8e-18 64.5 0.5 1.1e-05 24.9 0.0 4.4 4 0 0 4 4 4 3 Kelch motif Kelch_2 PF07646.15 ELR13687.1 - 1.6e-15 56.4 1.6 0.0013 18.6 0.0 4.5 4 0 0 4 4 4 3 Kelch motif Pox_Ag35 PF03286.14 ELR13687.1 - 0.042 13.6 3.8 0.069 12.9 1.0 2.1 2 0 0 2 2 2 0 Pox virus Ag35 surface protein PPP4R2 PF09184.11 ELR13687.1 - 0.21 11.1 3.6 0.34 10.5 3.6 1.3 1 0 0 1 1 1 0 PPP4R2 FYDLN_acid PF09538.10 ELR13687.1 - 0.44 11.3 7.0 0.73 10.5 4.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (FYDLN_acid) Ank_2 PF12796.7 ELR13688.1 - 4.7e-29 100.8 2.2 1.4e-12 48.0 0.1 2.2 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_5 PF13857.6 ELR13688.1 - 4.1e-20 71.6 0.4 5e-12 45.8 0.1 2.2 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 ELR13688.1 - 4.3e-15 55.4 1.4 1.4e-07 31.7 0.0 3.5 4 0 0 4 4 4 2 Ankyrin repeat Ank_4 PF13637.6 ELR13688.1 - 6.3e-15 55.3 0.5 1.8e-07 31.6 0.0 3.3 2 1 2 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 ELR13688.1 - 1.1e-08 34.6 0.7 0.0034 17.8 0.0 3.1 4 0 0 4 4 4 2 Ankyrin repeat BET PF17035.5 ELR13688.1 - 0.039 14.1 0.1 0.063 13.5 0.1 1.4 1 0 0 1 1 1 0 Bromodomain extra-terminal - transcription regulation PRMT5 PF05185.16 ELR13688.1 - 0.1 12.4 0.0 0.14 12.0 0.0 1.2 1 0 0 1 1 1 0 PRMT5 arginine-N-methyltransferase DEC-1_N PF04625.13 ELR13688.1 - 0.26 10.2 3.5 0.31 10.0 3.5 1.2 1 0 0 1 1 1 0 DEC-1 protein, N-terminal region PRIMA1 PF16101.5 ELR13688.1 - 0.3 11.2 3.6 3.2 7.8 4.3 2.0 2 0 0 2 2 2 0 Proline-rich membrane anchor 1 Glyco_hydro_16 PF00722.21 ELR13695.1 - 1.5e-06 27.8 0.1 2.1e-05 24.1 0.0 2.5 2 1 1 3 3 3 1 Glycosyl hydrolases family 16 F-box-like PF12937.7 ELR13697.1 - 5.5e-10 39.0 0.5 5.5e-10 39.0 0.5 2.0 2 0 0 2 2 2 1 F-box-like Ank_2 PF12796.7 ELR13697.1 - 2.2e-08 34.5 0.2 0.043 14.4 0.0 3.9 3 1 0 3 3 3 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 ELR13697.1 - 4.5e-08 32.7 0.9 0.55 11.0 0.0 4.8 5 0 0 5 5 5 3 Ankyrin repeat Ank PF00023.30 ELR13697.1 - 7e-07 29.4 0.7 0.11 13.0 0.0 4.7 5 0 0 5 5 5 2 Ankyrin repeat Ank_4 PF13637.6 ELR13697.1 - 1.9e-05 25.1 0.1 4.4 8.0 0.0 4.4 4 0 0 4 4 4 2 Ankyrin repeats (many copies) F-box PF00646.33 ELR13697.1 - 6.9e-05 22.6 0.6 0.00024 20.9 0.0 2.1 2 0 0 2 2 2 1 F-box domain Tho1_MOS11_C PF18592.1 ELR13697.1 - 0.018 14.8 0.0 0.039 13.8 0.0 1.5 1 0 0 1 1 1 0 Tho1/MOS11 C-terminal domain Sel1 PF08238.12 ELR13698.1 - 1.6e-48 162.0 47.5 9.6e-08 32.5 0.4 9.1 9 1 0 9 9 9 8 Sel1 repeat DUF977 PF06163.11 ELR13698.1 - 0.058 13.4 0.6 31 4.5 0.0 3.4 2 2 2 4 4 4 0 Bacterial protein of unknown function (DUF977) Pkinase_Tyr PF07714.17 ELR13699.1 - 5.9e-68 228.9 0.0 2.5e-42 145.0 0.0 4.1 2 1 2 4 4 4 4 Protein tyrosine kinase Pkinase PF00069.25 ELR13699.1 - 1.6e-64 217.8 0.0 1.2e-45 156.0 0.0 4.1 2 1 2 4 4 4 4 Protein kinase domain Haspin_kinase PF12330.8 ELR13699.1 - 7.9e-05 21.8 0.0 0.00012 21.1 0.0 1.3 1 0 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 ELR13699.1 - 0.025 14.5 0.0 0.025 14.5 0.0 2.6 2 1 0 2 2 2 0 Phosphotransferase enzyme family Kinase-like PF14531.6 ELR13699.1 - 0.051 12.9 0.0 0.085 12.2 0.0 1.3 1 0 0 1 1 1 0 Kinase-like Patatin PF01734.22 ELR13700.1 - 0.026 14.7 0.1 0.047 13.9 0.1 1.4 1 0 0 1 1 1 0 Patatin-like phospholipase CBS PF00571.28 ELR13702.1 - 3.5e-20 72.2 6.4 7.1e-09 36.0 0.1 4.3 4 0 0 4 4 4 4 CBS domain Peptidase_M28 PF04389.17 ELR13703.1 - 0.001 18.8 0.0 0.0014 18.4 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M28 PRP38_assoc PF12871.7 ELR13704.1 - 0.022 15.3 3.0 0.022 15.3 3.0 3.2 2 1 0 2 2 2 0 Pre-mRNA-splicing factor 38-associated hydrophilic C-term Mucin PF01456.17 ELR13704.1 - 0.2 11.6 5.9 0.31 11.0 5.9 1.3 1 0 0 1 1 1 0 Mucin-like glycoprotein WASH-7_N PF14745.6 ELR13704.1 - 1.1 7.7 3.5 0.22 10.0 0.2 1.4 2 0 0 2 2 2 0 WASH complex subunit 7, N-terminal SR-25 PF10500.9 ELR13704.1 - 2.1 7.9 20.1 9 5.8 20.1 2.0 1 1 0 1 1 1 0 Nuclear RNA-splicing-associated protein NAD_binding_2 PF03446.15 ELR13705.1 - 2.2e-31 109.2 0.2 3.1e-31 108.7 0.2 1.2 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.6 ELR13705.1 - 4.5e-07 30.1 0.2 9.8e-07 29.0 0.1 1.6 2 0 0 2 2 2 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase Shikimate_DH PF01488.20 ELR13705.1 - 8.4e-05 22.6 0.0 0.00076 19.5 0.0 2.3 3 0 0 3 3 3 1 Shikimate / quinate 5-dehydrogenase F420_oxidored PF03807.17 ELR13705.1 - 9e-05 23.0 0.0 0.00019 21.9 0.0 1.6 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent adh_short PF00106.25 ELR13705.1 - 0.021 14.3 0.0 6.6 6.1 0.0 2.4 2 1 0 2 2 2 0 short chain dehydrogenase DpaA_N PF16924.5 ELR13705.1 - 0.044 13.9 0.0 0.095 12.8 0.0 1.5 1 0 0 1 1 1 0 Dipicolinate synthase subunit A N-terminal domain IlvN PF07991.12 ELR13705.1 - 0.057 13.0 0.0 0.086 12.4 0.0 1.3 1 0 0 1 1 1 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain ApbA PF02558.16 ELR13705.1 - 0.06 13.0 0.0 0.15 11.7 0.0 1.7 2 0 0 2 2 2 0 Ketopantoate reductase PanE/ApbA TIR_2 PF13676.6 ELR13705.1 - 0.14 12.8 0.0 0.22 12.1 0.0 1.3 1 0 0 1 1 1 0 TIR domain Aa_trans PF01490.18 ELR13706.1 - 4.3e-14 52.0 12.0 4.5e-14 52.0 12.0 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein SPP PF06550.11 ELR13706.1 - 0.041 13.4 8.5 0.044 13.2 8.5 1.0 1 0 0 1 1 1 0 Signal-peptide peptidase, presenilin aspartyl protease RseC_MucC PF04246.12 ELR13706.1 - 0.27 11.2 10.1 0.34 10.9 3.1 2.1 1 1 1 2 2 2 0 Positive regulator of sigma(E), RseC/MucC Herpes_LMP1 PF05297.11 ELR13706.1 - 1.3 8.2 5.9 1.4 8.1 5.9 1.0 1 0 0 1 1 1 0 Herpesvirus latent membrane protein 1 (LMP1) Pkinase PF00069.25 ELR13707.1 - 0.00013 21.4 0.0 0.00031 20.2 0.0 1.6 1 0 0 1 1 1 1 Protein kinase domain PTPRCAP PF15713.5 ELR13707.1 - 0.00023 21.5 6.9 0.00023 21.5 6.9 1.6 2 0 0 2 2 1 1 Protein tyrosine phosphatase receptor type C-associated Sporozoite_P67 PF05642.11 ELR13707.1 - 0.006 14.7 7.3 0.0093 14.1 7.3 1.2 1 0 0 1 1 1 1 Sporozoite P67 surface antigen CPSF100_C PF13299.6 ELR13707.1 - 0.02 15.1 1.2 0.034 14.3 1.2 1.4 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal CDC45 PF02724.14 ELR13707.1 - 0.057 11.7 12.2 0.085 11.1 12.2 1.1 1 0 0 1 1 1 0 CDC45-like protein Paf1 PF03985.13 ELR13707.1 - 0.091 11.7 18.3 0.15 11.0 18.3 1.2 1 0 0 1 1 1 0 Paf1 Zip PF02535.22 ELR13707.1 - 0.098 11.9 0.3 0.14 11.3 0.3 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter RNA_pol_Rpc4 PF05132.14 ELR13707.1 - 0.11 13.0 1.4 0.23 11.9 1.4 1.5 1 0 0 1 1 1 0 RNA polymerase III RPC4 CobT PF06213.12 ELR13707.1 - 0.11 11.9 21.0 0.17 11.3 21.0 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Presenilin PF01080.17 ELR13707.1 - 0.19 10.5 4.3 0.28 9.9 4.3 1.2 1 0 0 1 1 1 0 Presenilin DUF913 PF06025.12 ELR13707.1 - 0.2 10.6 2.1 0.33 9.9 2.1 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Mpp10 PF04006.12 ELR13707.1 - 0.26 9.7 15.4 0.38 9.1 15.4 1.1 1 0 0 1 1 1 0 Mpp10 protein RR_TM4-6 PF06459.12 ELR13707.1 - 0.29 10.9 8.0 0.58 9.9 8.0 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 PI3K_1B_p101 PF10486.9 ELR13707.1 - 0.32 8.7 6.0 0.45 8.2 6.0 1.1 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit DNA_pol_phi PF04931.13 ELR13707.1 - 0.37 8.9 17.7 0.55 8.3 17.7 1.1 1 0 0 1 1 1 0 DNA polymerase phi DUF2052 PF09747.9 ELR13707.1 - 0.52 10.4 15.5 0.11 12.7 11.1 1.9 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) RRN3 PF05327.11 ELR13707.1 - 1.1 7.8 6.8 1.5 7.2 6.8 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 DHHW PF14286.6 ELR13707.1 - 1.1 8.5 4.9 1.6 7.9 4.9 1.1 1 0 0 1 1 1 0 DHHW protein Nop14 PF04147.12 ELR13707.1 - 1.1 7.4 17.3 1.6 6.9 17.3 1.1 1 0 0 1 1 1 0 Nop14-like family DDRGK PF09756.9 ELR13707.1 - 1.3 8.6 13.3 0.27 10.8 8.7 2.0 2 0 0 2 2 2 0 DDRGK domain SR-25 PF10500.9 ELR13707.1 - 1.3 8.5 14.6 2.3 7.8 14.6 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein TRAP_alpha PF03896.16 ELR13707.1 - 1.4 8.0 6.6 2.4 7.3 6.6 1.3 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit MRNIP PF15749.5 ELR13707.1 - 1.8 9.3 6.9 3.5 8.4 6.9 1.4 1 0 0 1 1 1 0 MRN-interacting protein Apt1 PF10351.9 ELR13707.1 - 2.2 7.0 8.3 3.2 6.5 8.3 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain LAP1C PF05609.12 ELR13707.1 - 2.4 7.1 9.1 4 6.4 9.1 1.2 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) V_ATPase_I PF01496.19 ELR13707.1 - 2.8 5.8 3.5 3.9 5.3 3.5 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family NOA36 PF06524.12 ELR13707.1 - 3.6 6.8 13.7 6.2 6.1 13.7 1.3 1 0 0 1 1 1 0 NOA36 protein RPN2_C PF18004.1 ELR13707.1 - 5 7.0 11.8 9 6.2 11.8 1.3 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain Pes-10 PF07149.11 ELR13707.1 - 5.5 5.9 15.1 11 5.0 15.1 1.4 1 0 0 1 1 1 0 Pes-10 Nbas_N PF15492.6 ELR13708.1 - 0.038 13.3 0.0 0.053 12.8 0.0 1.2 1 0 0 1 1 1 0 Neuroblastoma-amplified sequence, N terminal HeLo PF14479.6 ELR13709.1 - 0.018 14.9 0.2 0.021 14.6 0.2 1.0 1 0 0 1 1 1 0 Prion-inhibition and propagation Sulfakinin PF08257.11 ELR13709.1 - 5.5 7.4 7.2 0.49 10.6 1.5 2.4 2 0 0 2 2 2 0 Sulfakinin family Glyco_hydro_18 PF00704.28 ELR13710.1 - 4.8e-18 65.9 0.0 6.5e-18 65.5 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 Med5 PF08689.10 ELR13711.1 - 5.3 4.7 15.4 6.3 4.5 15.4 1.1 1 0 0 1 1 1 0 Mediator complex subunit Med5 Reticulon PF02453.17 ELR13712.1 - 0.0039 17.2 1.9 0.0039 17.2 1.9 1.6 2 0 0 2 2 2 1 Reticulon DUF805 PF05656.14 ELR13712.1 - 0.47 10.9 4.1 0.8 10.1 4.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF805) PIP5K PF01504.18 ELR13714.1 - 1.7e-75 253.8 0.2 1.1e-73 247.9 0.2 2.3 1 1 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase Dicty_CAR PF05462.11 ELR13714.1 - 0.00017 20.9 5.4 0.00028 20.1 5.4 1.2 1 0 0 1 1 1 1 Slime mold cyclic AMP receptor SpoVR PF04293.13 ELR13714.1 - 0.1 11.3 0.1 0.18 10.5 0.1 1.3 1 0 0 1 1 1 0 SpoVR like protein SR-25 PF10500.9 ELR13714.1 - 0.19 11.3 15.7 0.31 10.6 15.7 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein 7tm_1 PF00001.21 ELR13714.1 - 0.58 9.4 5.2 1.1 8.5 5.2 1.4 1 0 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) Frizzled PF01534.17 ELR13714.1 - 1 8.3 11.6 8 5.4 11.6 2.0 1 1 0 1 1 1 0 Frizzled/Smoothened family membrane region AP-5_subunit_s1 PF15001.6 ELR13715.1 - 4 7.4 5.7 1.7 8.6 0.3 2.2 2 0 0 2 2 2 0 AP-5 complex subunit sigma-1 Thioredoxin PF00085.20 ELR13716.1 - 4.5e-35 119.7 0.1 2e-23 82.4 0.0 3.1 3 0 0 3 3 3 2 Thioredoxin Thioredoxin_6 PF13848.6 ELR13716.1 - 2.9e-14 53.4 0.3 4.7e-08 33.1 0.1 3.5 2 1 1 3 3 3 3 Thioredoxin-like domain OST3_OST6 PF04756.13 ELR13716.1 - 4.3e-07 29.6 0.2 0.0045 16.4 0.1 2.6 3 0 0 3 3 3 2 OST3 / OST6 family, transporter family Thioredoxin_2 PF13098.6 ELR13716.1 - 2.8e-05 24.5 0.1 0.036 14.5 0.0 2.7 2 0 0 2 2 2 2 Thioredoxin-like domain ERp29_N PF07912.13 ELR13716.1 - 0.00032 20.8 0.1 0.27 11.4 0.0 3.1 3 0 0 3 3 3 2 ERp29, N-terminal domain Thioredoxin_8 PF13905.6 ELR13716.1 - 0.00057 20.2 0.2 0.034 14.5 0.0 2.9 3 0 0 3 3 3 1 Thioredoxin-like Thioredoxin_7 PF13899.6 ELR13716.1 - 0.0088 16.2 1.1 0.23 11.7 0.1 3.5 3 2 0 3 3 3 1 Thioredoxin-like AhpC-TSA PF00578.21 ELR13716.1 - 0.03 14.2 0.0 0.075 13.0 0.0 1.6 1 0 0 1 1 1 0 AhpC/TSA family Herpes_UL6 PF01763.16 ELR13717.1 - 0.0013 17.3 2.0 0.0018 16.9 2.0 1.1 1 0 0 1 1 1 1 Herpesvirus UL6 like CENP-Q PF13094.6 ELR13717.1 - 0.0041 17.3 11.7 0.0086 16.3 11.7 1.5 1 0 0 1 1 1 1 CENP-Q, a CENPA-CAD centromere complex subunit Spc7 PF08317.11 ELR13717.1 - 0.0095 14.8 13.1 0.042 12.7 12.1 2.0 2 0 0 2 2 2 1 Spc7 kinetochore protein FapA PF03961.13 ELR13717.1 - 0.042 12.4 7.0 0.058 12.0 7.0 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A PIEZO PF15917.5 ELR13717.1 - 0.12 11.9 9.4 0.19 11.2 9.4 1.3 1 0 0 1 1 1 0 Piezo DUF763 PF05559.11 ELR13717.1 - 0.18 11.0 2.5 0.33 10.1 2.5 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF763) Atg14 PF10186.9 ELR13717.1 - 0.27 10.3 7.7 0.44 9.6 7.7 1.4 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF4407 PF14362.6 ELR13717.1 - 0.31 10.3 7.3 0.45 9.8 7.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Exonuc_VII_L PF02601.15 ELR13717.1 - 0.34 10.5 5.0 0.55 9.7 5.0 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF948 PF06103.11 ELR13717.1 - 0.47 10.7 1.3 1 9.7 1.3 1.5 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF948) V_ATPase_I PF01496.19 ELR13717.1 - 1 7.2 5.3 1.3 6.8 5.3 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family PH PF00169.29 ELR13717.1 - 1.1 9.8 7.7 1.1 9.8 0.1 3.3 4 0 0 4 4 3 0 PH domain NARP1 PF12569.8 ELR13717.1 - 1.5 7.6 11.3 2.1 7.1 11.3 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 CpxA_peri PF16527.5 ELR13717.1 - 1.7 9.0 5.0 5.2 7.5 5.0 1.8 1 0 0 1 1 1 0 Two-component sensor protein CpxA, periplasmic domain ZapB PF06005.12 ELR13717.1 - 1.9 9.0 17.8 0.44 11.0 12.4 2.5 3 0 0 3 3 3 0 Cell division protein ZapB COG2 PF06148.11 ELR13717.1 - 3.6 7.7 7.9 92 3.1 0.0 2.4 2 0 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 FlaC_arch PF05377.11 ELR13717.1 - 5.4 7.5 5.8 1.1 9.7 1.2 2.2 3 0 0 3 3 2 0 Flagella accessory protein C (FlaC) YqfQ PF14181.6 ELR13717.1 - 7.3 6.7 16.1 14 5.8 0.1 2.4 2 0 0 2 2 2 0 YqfQ-like protein DUF1682 PF07946.14 ELR13717.1 - 8.3 5.5 17.4 11 5.1 17.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) Myb_DNA-bind_2 PF08914.11 ELR13718.1 - 1.6e-13 50.6 0.0 4.2e-13 49.3 0.0 1.6 1 0 0 1 1 1 1 Rap1 Myb domain BRCT_2 PF16589.5 ELR13718.1 - 0.00085 19.7 0.0 0.0022 18.4 0.0 1.8 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain Myb_DNA-binding PF00249.31 ELR13718.1 - 0.069 13.4 1.8 2.2 8.6 0.1 3.0 2 1 0 2 2 2 0 Myb-like DNA-binding domain Rap1_C PF11626.8 ELR13718.1 - 0.087 12.9 0.0 0.55 10.4 0.0 2.4 2 2 0 2 2 2 0 TRF2-interacting telomeric protein/Rap1 - C terminal domain Mit_KHE1 PF10173.9 ELR13718.1 - 0.16 12.0 0.9 0.29 11.2 0.3 1.6 1 1 0 1 1 1 0 Mitochondrial K+-H+ exchange-related Nucleo_P87 PF07267.11 ELR13718.1 - 3.2 6.5 21.3 0.024 13.5 8.2 2.0 2 0 0 2 2 2 0 Nucleopolyhedrovirus capsid protein P87 PH PF00169.29 ELR13719.1 - 5.8e-14 52.5 0.0 9.2e-14 51.8 0.0 1.3 1 0 0 1 1 1 1 PH domain PH_11 PF15413.6 ELR13719.1 - 5.6e-05 23.5 0.4 0.00023 21.5 0.4 2.0 1 1 0 1 1 1 1 Pleckstrin homology domain PH_3 PF14593.6 ELR13719.1 - 0.0089 16.1 0.8 3.4 7.8 0.2 3.2 2 1 0 2 2 2 1 PH domain PH_8 PF15409.6 ELR13719.1 - 0.057 13.7 0.1 0.14 12.4 0.1 1.7 1 0 0 1 1 1 0 Pleckstrin homology domain Chondroitinas_B PF14592.6 ELR13720.1 - 7.6e-47 160.1 4.4 9.8e-47 159.8 4.4 1.1 1 0 0 1 1 1 1 Chondroitinase B NosD PF05048.13 ELR13720.1 - 4.8e-07 29.3 12.7 1.2e-06 28.0 12.5 1.5 1 1 0 1 1 1 1 Periplasmic copper-binding protein (NosD) Beta_helix PF13229.6 ELR13720.1 - 2.8e-05 24.0 16.6 7.6e-05 22.6 16.4 2.0 1 1 0 1 1 1 1 Right handed beta helix region dCMP_cyt_deam_2 PF08211.12 ELR13720.1 - 0.04 14.1 0.0 2.7 8.2 0.0 2.7 3 1 0 3 3 3 0 Cytidine and deoxycytidylate deaminase zinc-binding region DUF641 PF04859.12 ELR13720.1 - 0.21 12.0 0.9 0.38 11.1 0.9 1.4 1 0 0 1 1 1 0 Plant protein of unknown function (DUF641) MDM10 PF12519.8 ELR13723.1 - 4.3e-12 45.6 0.6 8.6e-12 44.7 0.5 1.3 1 1 0 1 1 1 1 Mitochondrial distribution and morphology protein 10 Porin_3 PF01459.22 ELR13723.1 - 8.1e-12 45.2 0.0 1.2e-11 44.6 0.0 1.2 1 0 0 1 1 1 1 Eukaryotic porin ECH_1 PF00378.20 ELR13724.1 - 4.5e-46 157.2 0.0 8e-43 146.6 0.0 2.1 2 0 0 2 2 2 2 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 ELR13724.1 - 2.6e-25 89.7 0.0 3.7e-25 89.1 0.0 1.2 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase Peptidase_C26 PF07722.13 ELR13725.1 - 3.5e-17 62.9 0.0 1.7e-15 57.3 0.0 2.3 1 1 0 1 1 1 1 Peptidase C26 GATase PF00117.28 ELR13725.1 - 0.00011 22.0 0.0 0.0013 18.5 0.0 2.2 2 1 0 2 2 2 1 Glutamine amidotransferase class-I FliG_C PF01706.16 ELR13725.1 - 0.19 11.9 0.1 0.39 10.9 0.1 1.4 1 0 0 1 1 1 0 FliG C-terminal domain Cauli_VI PF01693.16 ELR13726.1 - 1.7e-20 73.0 1.0 3.1e-20 72.2 1.0 1.5 1 0 0 1 1 1 1 Caulimovirus viroplasmin DUF4805 PF16063.5 ELR13726.1 - 0.0029 17.0 8.3 0.0035 16.7 8.3 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4805) FAM104 PF15434.6 ELR13726.1 - 0.027 15.0 6.5 0.047 14.3 6.5 1.3 1 0 0 1 1 1 0 Family 104 MCM_bind PF09739.9 ELR13726.1 - 0.042 12.3 3.1 0.042 12.3 3.1 1.1 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor Barttin PF15462.6 ELR13726.1 - 0.15 11.8 4.5 0.18 11.5 4.5 1.1 1 0 0 1 1 1 0 Bartter syndrome, infantile, with sensorineural deafness (Barttin) Roughex PF06020.11 ELR13726.1 - 0.17 10.9 3.8 0.2 10.7 3.8 1.1 1 0 0 1 1 1 0 Drosophila roughex protein Ribosomal_60s PF00428.19 ELR13726.1 - 1.3 9.7 4.3 3.1 8.5 4.1 1.7 2 0 0 2 2 2 0 60s Acidic ribosomal protein GREB1 PF15782.5 ELR13726.1 - 2.1 5.3 5.6 2.4 5.2 5.6 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Hid1 PF12722.7 ELR13726.1 - 2.2 6.3 7.9 2.5 6.1 7.9 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein FAM176 PF14851.6 ELR13726.1 - 2.8 7.6 5.3 3.9 7.1 5.3 1.4 1 1 0 1 1 1 0 FAM176 family Cu-oxidase_2 PF07731.14 ELR13728.1 - 1.4e-21 76.7 0.0 2.3e-21 76.0 0.0 1.4 1 0 0 1 1 1 1 Multicopper oxidase Cu-oxidase PF00394.22 ELR13728.1 - 0.0089 16.2 0.0 0.07 13.2 0.0 2.2 3 0 0 3 3 3 1 Multicopper oxidase TPT PF03151.16 ELR13729.1 - 6.4e-12 45.4 3.4 8.8e-12 45.0 3.1 1.3 1 1 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 ELR13729.1 - 6.3e-05 23.2 7.7 0.13 12.4 0.0 2.5 2 1 0 2 2 2 2 EamA-like transporter family SH3_9 PF14604.6 ELR13731.1 - 8.2e-17 60.8 0.6 3.8e-14 52.3 0.1 2.2 2 0 0 2 2 2 2 Variant SH3 domain SH3_1 PF00018.28 ELR13731.1 - 2.7e-14 52.5 0.2 3.9e-12 45.6 0.0 2.1 2 0 0 2 2 2 2 SH3 domain SH3_2 PF07653.17 ELR13731.1 - 1.3e-09 37.5 0.3 4.1e-07 29.6 0.0 2.1 2 0 0 2 2 2 2 Variant SH3 domain DUF418 PF04235.12 ELR13732.1 - 0.026 14.5 0.0 0.034 14.1 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF418) DUF4381 PF14316.6 ELR13732.1 - 0.085 13.1 1.3 0.14 12.4 1.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) RasGEF PF00617.19 ELR13733.1 - 6.2e-41 140.5 0.1 9.4e-41 139.9 0.1 1.2 1 0 0 1 1 1 1 RasGEF domain V4R PF02830.18 ELR13734.1 - 0.00013 21.8 0.5 0.00064 19.7 0.5 2.0 1 1 0 1 1 1 1 V4R domain TPR_2 PF07719.17 ELR13735.1 - 1.7e-13 49.6 2.8 0.0021 18.0 0.8 7.2 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_1 PF00515.28 ELR13735.1 - 1.9e-10 40.1 0.3 0.028 14.2 0.6 5.9 6 0 0 6 6 5 2 Tetratricopeptide repeat TPR_19 PF14559.6 ELR13735.1 - 3.5e-10 40.3 2.0 0.0016 18.9 0.0 4.4 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_7 PF13176.6 ELR13735.1 - 2.5e-07 30.2 1.1 0.55 10.4 0.0 4.9 5 0 0 5 5 4 2 Tetratricopeptide repeat TPR_12 PF13424.6 ELR13735.1 - 2.7e-07 30.8 6.4 0.0012 19.1 1.0 4.7 2 1 1 4 4 4 2 Tetratricopeptide repeat TPR_16 PF13432.6 ELR13735.1 - 8.7e-07 29.5 2.9 0.0047 17.5 0.1 4.3 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_21 PF09976.9 ELR13735.1 - 2.1e-06 27.6 0.2 1.4e-05 24.9 0.0 2.1 1 1 1 2 2 2 1 Tetratricopeptide repeat-like domain TPR_14 PF13428.6 ELR13735.1 - 5.2e-06 26.8 6.0 1.9 9.5 0.0 6.6 4 3 4 8 8 6 1 Tetratricopeptide repeat BTAD PF03704.17 ELR13735.1 - 5.1e-05 23.7 0.6 0.02 15.3 0.1 3.0 2 1 0 3 3 2 1 Bacterial transcriptional activator domain ANAPC3 PF12895.7 ELR13735.1 - 6e-05 23.2 7.4 0.023 14.9 1.0 3.9 2 1 2 4 4 4 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_15 PF13429.6 ELR13735.1 - 0.0001 21.6 2.8 0.018 14.3 0.3 3.7 1 1 3 4 4 4 1 Tetratricopeptide repeat TPR_8 PF13181.6 ELR13735.1 - 0.00031 20.7 2.3 3.6 8.0 0.0 5.3 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_11 PF13414.6 ELR13735.1 - 0.0042 16.7 7.1 0.84 9.4 1.0 5.4 5 1 1 6 6 6 1 TPR repeat TPR_MalT PF17874.1 ELR13735.1 - 0.0048 16.3 4.2 0.56 9.5 0.0 2.8 2 1 1 3 3 3 2 MalT-like TPR region TPR_10 PF13374.6 ELR13735.1 - 0.0058 16.5 1.9 29 4.7 0.1 4.5 5 0 0 5 5 4 0 Tetratricopeptide repeat TPR_17 PF13431.6 ELR13735.1 - 0.009 16.3 0.5 42 4.8 0.2 4.6 5 0 0 5 5 3 0 Tetratricopeptide repeat TPR_6 PF13174.6 ELR13735.1 - 0.031 14.9 4.0 2.9 8.7 0.0 4.8 5 0 0 5 5 4 0 Tetratricopeptide repeat TPR_9 PF13371.6 ELR13735.1 - 0.032 14.4 0.2 0.93 9.7 0.0 3.2 3 0 0 3 3 2 0 Tetratricopeptide repeat SKA1 PF07160.12 ELR13735.1 - 0.075 12.9 2.9 0.14 12.0 2.9 1.4 1 0 0 1 1 1 0 Spindle and kinetochore-associated protein 1 RasGEF_N PF00618.20 ELR13737.1 - 1.6e-05 25.1 0.1 0.00018 21.7 0.1 1.9 1 1 0 1 1 1 1 RasGEF N-terminal motif Cyt-b5 PF00173.28 ELR13738.1 - 1.8e-06 28.0 0.1 3.4e-06 27.1 0.1 1.6 1 1 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain PAS_3 PF08447.12 ELR13738.1 - 0.041 14.2 0.5 0.32 11.3 0.0 2.3 2 1 1 3 3 3 0 PAS fold AAA_23 PF13476.6 ELR13739.1 - 0.0097 16.4 9.5 0.012 16.1 9.5 1.2 1 0 0 1 1 1 1 AAA domain CAF-1_p150 PF11600.8 ELR13739.1 - 0.22 11.2 33.3 0.35 10.6 33.3 1.3 1 0 0 1 1 1 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal RNA_polI_A34 PF08208.11 ELR13739.1 - 2.2 8.4 28.1 4.5 7.3 28.1 1.5 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 RabGAP-TBC PF00566.18 ELR13740.1 - 6.6e-06 25.9 0.1 6.6e-06 25.9 0.1 2.2 2 0 0 2 2 2 1 Rab-GTPase-TBC domain S1_2 PF13509.6 ELR13740.1 - 0.036 14.1 0.2 0.74 9.9 0.0 2.8 3 0 0 3 3 3 0 S1 domain CDC45 PF02724.14 ELR13740.1 - 1.4 7.1 7.3 2.4 6.3 7.3 1.3 1 0 0 1 1 1 0 CDC45-like protein F-protein PF00469.20 ELR13740.1 - 2.1 7.9 7.4 11 5.6 0.0 2.5 2 0 0 2 2 2 0 Negative factor, (F-Protein) or Nef RNA_polI_A34 PF08208.11 ELR13740.1 - 3.7 7.6 24.6 1.4 9.0 21.6 1.7 1 1 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 Beta-lactamase PF00144.24 ELR13741.1 - 4.3e-21 75.5 0.0 1.7e-20 73.6 0.0 1.8 1 1 0 1 1 1 1 Beta-lactamase tRNA-synt_1 PF00133.22 ELR13745.1 - 1.7e-37 129.0 0.0 7.5e-31 107.0 0.0 2.4 2 1 0 2 2 2 2 tRNA synthetases class I (I, L, M and V) tRNA-synt_1g PF09334.11 ELR13745.1 - 2.1e-13 49.8 0.7 1.3e-09 37.3 0.0 3.0 3 0 0 3 3 3 2 tRNA synthetases class I (M) Anticodon_1 PF08264.13 ELR13745.1 - 1.4e-09 38.1 0.0 3e-09 37.0 0.0 1.5 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1e PF01406.19 ELR13745.1 - 6e-08 32.4 0.0 1.2e-07 31.4 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain CDC45 PF02724.14 ELR13746.1 - 0.011 14.1 19.1 0.037 12.3 2.7 2.1 2 0 0 2 2 2 0 CDC45-like protein DUF3772 PF12607.8 ELR13746.1 - 0.049 13.4 2.0 0.14 11.9 2.0 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF3772) Nop14 PF04147.12 ELR13746.1 - 0.17 10.1 22.9 0.31 9.2 11.1 2.1 2 0 0 2 2 2 0 Nop14-like family Spore_coat_CotO PF14153.6 ELR13746.1 - 0.93 9.4 13.6 1.9 8.4 13.6 1.4 1 0 0 1 1 1 0 Spore coat protein CotO NOA36 PF06524.12 ELR13746.1 - 2.8 7.2 28.8 1.7 7.9 7.1 2.8 3 0 0 3 3 3 0 NOA36 protein SLC12 PF03522.15 ELR13746.1 - 2.9 6.8 6.3 6.3 5.7 6.3 1.5 1 0 0 1 1 1 0 Solute carrier family 12 Zip PF02535.22 ELR13746.1 - 6.8 5.8 8.5 14 4.8 8.5 1.4 1 0 0 1 1 1 0 ZIP Zinc transporter MCM_bind PF09739.9 ELR13746.1 - 7 5.0 7.2 14 4.0 7.2 1.4 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor Pox_Ag35 PF03286.14 ELR13746.1 - 8.5 6.1 24.6 3.4 7.4 12.8 2.6 2 0 0 2 2 2 0 Pox virus Ag35 surface protein FancD2 PF14631.6 ELR13746.1 - 8.8 3.6 8.3 12 3.1 8.3 1.1 1 0 0 1 1 1 0 Fanconi anaemia protein FancD2 nuclease RasGEF PF00617.19 ELR13747.1 - 1.4e-15 57.9 0.1 2.3e-15 57.2 0.1 1.4 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 ELR13747.1 - 0.0071 16.6 0.1 0.018 15.3 0.1 1.7 1 0 0 1 1 1 1 RasGEF N-terminal motif Ycf66_N PF07444.11 ELR13747.1 - 0.11 12.7 0.0 0.25 11.5 0.0 1.6 1 0 0 1 1 1 0 Ycf66 protein N-terminus HATPase_c PF02518.26 ELR13748.1 - 6.1e-26 91.1 0.0 1e-25 90.4 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 ELR13748.1 - 6.3e-13 48.6 0.3 1.4e-12 47.4 0.3 1.6 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain Response_reg PF00072.24 ELR13748.1 - 1e-12 48.2 3.6 2.4e-07 30.9 0.5 3.9 2 1 0 2 2 2 2 Response regulator receiver domain Stealth_CR3 PF17102.5 ELR13748.1 - 0.15 12.0 0.1 27 4.8 0.0 2.7 2 0 0 2 2 2 0 Stealth protein CR3, conserved region 3 Patatin PF01734.22 ELR13749.1 - 1.1e-12 48.6 0.0 5.1e-12 46.4 0.0 2.2 2 0 0 2 2 2 1 Patatin-like phospholipase Pro_isomerase PF00160.21 ELR13751.1 - 1.3e-53 181.5 0.0 1.5e-53 181.3 0.0 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD E1-E2_ATPase PF00122.20 ELR13752.1 - 1.1e-55 187.9 1.0 1.1e-55 187.9 1.0 2.5 3 0 0 3 3 3 1 E1-E2 ATPase Cation_ATPase_C PF00689.21 ELR13752.1 - 4.5e-52 176.4 1.6 4.5e-52 176.4 1.6 1.7 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.26 ELR13752.1 - 1e-22 81.5 4.7 4e-22 79.5 4.7 2.1 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 ELR13752.1 - 7.6e-18 64.4 0.0 4.5e-17 61.9 0.0 2.2 2 0 0 2 2 2 1 Cation transport ATPase (P-type) Cation_ATPase_N PF00690.26 ELR13752.1 - 2.1e-17 62.6 1.2 3.9e-17 61.7 0.1 2.1 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 ELR13752.1 - 1.9e-05 24.5 2.2 0.0014 18.4 0.6 2.4 1 1 1 2 2 2 2 haloacid dehalogenase-like hydrolase HAD PF12710.7 ELR13752.1 - 0.0038 17.7 0.4 0.012 16.0 0.1 2.1 2 1 0 2 2 2 1 haloacid dehalogenase-like hydrolase DUF4870 PF09685.10 ELR13752.1 - 7.9 6.6 10.1 0.17 12.0 0.1 3.1 3 1 0 3 3 3 0 Domain of unknown function (DUF4870) DUF4461 PF14688.6 ELR13753.1 - 5.4e-21 75.7 2.0 1.9e-17 64.0 0.2 2.0 2 0 0 2 2 2 2 Domain of unknown function (DUF4461) GHMP_kinases_N PF00288.26 ELR13754.1 - 0.28 11.4 2.0 0.67 10.2 2.0 1.6 1 0 0 1 1 1 0 GHMP kinases N terminal domain Pkinase PF00069.25 ELR13755.1 - 9.4e-81 271.0 0.0 1.4e-80 270.4 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR13755.1 - 1.9e-39 135.5 0.0 2.7e-39 135.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ELR13755.1 - 7.8e-07 28.7 0.0 1.6e-05 24.4 0.0 2.2 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.14 ELR13755.1 - 2.1e-06 27.2 0.3 4e-06 26.3 0.3 1.5 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 ELR13755.1 - 1.1e-05 25.5 1.7 0.002 18.1 0.3 2.7 2 1 1 3 3 3 2 Phosphotransferase enzyme family RIO1 PF01163.22 ELR13755.1 - 0.00019 21.1 0.4 0.00053 19.6 0.1 1.8 2 0 0 2 2 2 1 RIO1 family FTA2 PF13095.6 ELR13755.1 - 0.069 12.8 0.1 13 5.3 0.0 2.3 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Pns11_12 PF17464.2 ELR13755.1 - 0.91 9.2 5.0 1.5 8.5 5.0 1.4 1 0 0 1 1 1 0 Non-structural protein 11 and 12 Catalase PF00199.19 ELR13756.1 - 1.9e-180 600.0 0.0 2.3e-180 599.7 0.0 1.1 1 0 0 1 1 1 1 Catalase Catalase-rel PF06628.12 ELR13756.1 - 3.3e-20 72.1 0.0 7.7e-20 70.9 0.0 1.7 1 0 0 1 1 1 1 Catalase-related immune-responsive Catalase_C PF18011.1 ELR13756.1 - 4.1e-16 59.0 0.1 8.7e-16 57.9 0.1 1.5 1 0 0 1 1 1 1 C-terminal domain found in long catalases DJ-1_PfpI PF01965.24 ELR13756.1 - 2.1e-10 40.7 0.1 4.7e-09 36.3 0.1 2.3 1 1 0 1 1 1 1 DJ-1/PfpI family NTP_transf_3 PF12804.7 ELR13756.1 - 0.11 12.8 0.1 0.38 11.1 0.1 1.9 1 1 1 2 2 2 0 MobA-like NTP transferase domain CS PF04969.16 ELR13757.1 - 8.1e-16 58.8 0.0 2.3e-15 57.3 0.0 1.8 2 0 0 2 2 2 1 CS domain DUF2935 PF11155.8 ELR13757.1 - 0.062 13.6 0.5 0.1 12.9 0.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF2935) SHOCT PF09851.9 ELR13758.1 - 0.0019 17.9 1.4 0.0037 16.9 1.4 1.5 1 0 0 1 1 1 1 Short C-terminal domain SelP_N PF04592.14 ELR13758.1 - 0.0032 16.9 15.5 0.004 16.6 15.5 1.1 1 0 0 1 1 1 1 Selenoprotein P, N terminal region Myc_N PF01056.18 ELR13758.1 - 0.0038 17.2 1.6 0.0043 17.0 1.6 1.1 1 0 0 1 1 1 1 Myc amino-terminal region DMAP_binding PF06464.11 ELR13758.1 - 0.016 16.0 2.7 0.035 14.9 2.7 1.6 1 1 0 1 1 1 0 DMAP1-binding Domain DUF935 PF06074.12 ELR13758.1 - 0.017 13.9 0.2 0.017 13.9 0.2 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF935) GvpG PF05120.12 ELR13758.1 - 0.021 14.9 0.6 0.021 14.9 0.6 1.8 2 0 0 2 2 2 0 Gas vesicle protein G Cwf_Cwc_15 PF04889.12 ELR13758.1 - 0.049 13.4 7.7 0.058 13.1 7.7 1.1 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein NAP PF00956.18 ELR13758.1 - 0.099 11.8 1.6 0.11 11.6 1.6 1.1 1 0 0 1 1 1 0 Nucleosome assembly protein (NAP) Prothymosin PF03247.14 ELR13758.1 - 0.61 10.6 14.3 0.82 10.2 14.3 1.2 1 0 0 1 1 1 0 Prothymosin/parathymosin family Zip PF02535.22 ELR13758.1 - 6.3 5.9 9.5 7 5.8 9.5 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter DNA_pol_phi PF04931.13 ELR13758.1 - 8.6 4.3 7.3 9.3 4.2 7.3 1.1 1 0 0 1 1 1 0 DNA polymerase phi NAGLU PF05089.12 ELR13759.1 - 1.7e-68 231.0 0.0 2.8e-68 230.3 0.0 1.3 1 0 0 1 1 1 1 Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain NAGLU_C PF12972.7 ELR13759.1 - 1.4e-55 188.8 0.1 7.3e-54 183.1 0.1 2.3 1 1 0 1 1 1 1 Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain Peptidase_S8 PF00082.22 ELR13759.1 - 1.3e-28 100.2 15.8 4.4e-28 98.4 15.8 1.8 1 1 0 1 1 1 1 Subtilase family Kelch_6 PF13964.6 ELR13760.1 - 3.2e-29 100.2 10.0 6e-08 32.7 0.1 6.0 4 1 2 6 6 6 5 Kelch motif Kelch_4 PF13418.6 ELR13760.1 - 1.8e-27 95.0 8.9 1.6e-07 31.2 0.2 5.2 6 0 0 6 6 6 4 Galactose oxidase, central domain Kelch_5 PF13854.6 ELR13760.1 - 3.3e-27 94.0 9.0 2.6e-06 27.3 0.1 5.6 6 0 0 6 6 6 5 Kelch motif Kelch_2 PF07646.15 ELR13760.1 - 6e-27 92.6 10.7 1.9e-07 30.8 0.1 6.2 6 0 0 6 6 6 4 Kelch motif Kelch_3 PF13415.6 ELR13760.1 - 9.3e-27 92.8 0.7 8e-07 29.2 0.3 4.6 4 0 0 4 4 4 4 Galactose oxidase, central domain Kelch_1 PF01344.25 ELR13760.1 - 5.5e-24 83.5 12.5 3.7e-06 26.4 0.4 5.0 5 0 0 5 5 5 4 Kelch motif F-box-like PF12937.7 ELR13760.1 - 1.4e-06 28.1 2.6 1.7e-06 27.8 0.8 2.2 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 ELR13760.1 - 0.0098 15.8 0.6 0.021 14.7 0.6 1.4 1 0 0 1 1 1 1 F-box domain MoaF_C PF17409.2 ELR13760.1 - 0.22 11.2 2.1 2.2 8.0 0.0 2.8 3 0 0 3 3 3 0 MoaF C-terminal domain GalP_UDP_transf PF01087.22 ELR13761.1 - 5.3e-55 186.7 0.8 4.3e-54 183.7 0.0 2.5 3 1 1 4 4 4 1 Galactose-1-phosphate uridyl transferase, N-terminal domain GalP_UDP_tr_C PF02744.17 ELR13761.1 - 7.2e-52 175.5 0.0 4.3e-32 111.1 0.0 2.2 1 1 1 2 2 2 2 Galactose-1-phosphate uridyl transferase, C-terminal domain HIT PF01230.23 ELR13761.1 - 0.019 15.7 0.1 0.077 13.7 0.1 2.0 2 1 0 2 2 2 0 HIT domain PBP1_TM PF14812.6 ELR13761.1 - 0.39 11.1 3.2 0.72 10.3 3.2 1.3 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DUF2403 PF10290.9 ELR13763.1 - 0.059 13.8 0.0 0.069 13.6 0.0 1.2 1 0 0 1 1 1 0 Glycine-rich protein domain (DUF2403) Tad PF13400.6 ELR13763.1 - 0.11 12.8 3.3 0.15 12.4 3.3 1.2 1 0 0 1 1 1 0 Putative Flp pilus-assembly TadE/G-like Sybindin PF04099.12 ELR13764.1 - 5.4e-47 159.3 0.5 6.2e-47 159.1 0.5 1.0 1 0 0 1 1 1 1 Sybindin-like family Sedlin_N PF04628.13 ELR13764.1 - 1.4e-12 47.8 0.1 1.7e-12 47.6 0.1 1.1 1 0 0 1 1 1 1 Sedlin, N-terminal conserved region LRR_6 PF13516.6 ELR13765.1 - 2e-13 49.2 10.4 0.12 12.5 0.0 8.5 9 0 0 9 9 9 5 Leucine Rich repeat LRR_8 PF13855.6 ELR13765.1 - 4.9e-12 45.4 4.3 9.6e-05 22.1 0.2 4.0 3 2 1 4 4 4 3 Leucine rich repeat LRR_4 PF12799.7 ELR13765.1 - 1.1e-05 25.7 10.0 0.49 10.9 0.0 5.7 2 2 4 7 7 7 3 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 ELR13765.1 - 4.6 8.2 9.1 38 5.4 0.0 5.9 8 1 0 8 8 8 0 Leucine Rich Repeat Polyketide_cyc2 PF10604.9 ELR13766.1 - 6.5e-10 39.4 0.4 8.1e-10 39.1 0.4 1.1 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport Polyketide_cyc2 PF10604.9 ELR13767.1 - 3.1e-15 56.7 0.1 3.6e-15 56.5 0.1 1.0 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport Ank_2 PF12796.7 ELR13768.1 - 2.2e-21 76.2 0.0 1.9e-10 41.2 0.0 2.3 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.30 ELR13768.1 - 5.6e-19 67.7 0.3 2.2e-05 24.7 0.0 3.4 3 0 0 3 3 3 3 Ankyrin repeat Ank_5 PF13857.6 ELR13768.1 - 5.8e-18 64.7 0.1 5.5e-06 26.6 0.0 3.9 1 1 3 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 ELR13768.1 - 3e-15 54.8 0.1 0.0015 18.9 0.0 4.3 4 1 1 5 5 5 3 Ankyrin repeat Ank_4 PF13637.6 ELR13768.1 - 5.5e-15 55.5 0.0 6.4e-07 29.8 0.0 3.3 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Cu_amine_oxid PF01179.20 ELR13769.1 - 5.3e-97 325.3 1.7 1.2e-76 258.3 0.1 2.1 1 1 1 2 2 2 2 Copper amine oxidase, enzyme domain Cu_amine_oxidN2 PF02727.16 ELR13769.1 - 2.1e-06 27.9 0.0 5.3e-06 26.6 0.0 1.7 2 0 0 2 2 2 1 Copper amine oxidase, N2 domain G_path_suppress PF15991.5 ELR13770.1 - 3.4e-10 40.5 1.1 7.2e-10 39.5 1.1 1.5 1 1 0 1 1 1 1 G-protein pathway suppressor Tmemb_cc2 PF10267.9 ELR13770.1 - 0.052 12.7 3.0 0.07 12.3 3.0 1.1 1 0 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein RAP1 PF07218.11 ELR13770.1 - 0.24 9.6 3.6 0.31 9.3 3.6 1.0 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) CDC27 PF09507.10 ELR13770.1 - 0.91 8.8 6.7 1.3 8.3 6.7 1.1 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 ubiquitin PF00240.23 ELR13772.1 - 0.00052 19.7 0.1 0.0018 18.0 0.1 1.9 1 1 0 1 1 1 1 Ubiquitin family Ubiquitin_2 PF14560.6 ELR13772.1 - 0.0014 19.0 0.3 0.0014 19.0 0.3 2.6 3 1 0 3 3 3 1 Ubiquitin-like domain AMP-binding PF00501.28 ELR13773.1 - 1e-87 294.5 0.0 1.3e-87 294.1 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 ELR13773.1 - 2.1e-18 67.1 1.6 2.4e-18 66.9 0.2 1.9 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain GH3 PF03321.13 ELR13773.1 - 0.0071 15.3 0.0 0.028 13.3 0.0 1.8 2 0 0 2 2 2 1 GH3 auxin-responsive promoter Peptidase_S66 PF02016.15 ELR13773.1 - 0.12 12.5 0.0 0.26 11.4 0.0 1.5 1 0 0 1 1 1 0 LD-carboxypeptidase N-terminal domain DUF229 PF02995.17 ELR13774.1 - 4.9e-35 121.1 0.0 1.6e-27 96.3 0.1 2.8 2 1 0 2 2 2 2 Protein of unknown function (DUF229) Sulfatase PF00884.23 ELR13774.1 - 0.00028 20.4 0.9 0.0054 16.2 0.0 2.6 1 1 1 2 2 2 2 Sulfatase ubiquitin PF00240.23 ELR13775.1 - 3.1e-70 231.9 6.9 1.2e-34 117.9 0.8 2.0 2 0 0 2 2 2 2 Ubiquitin family Rad60-SLD PF11976.8 ELR13775.1 - 2.1e-34 117.2 7.4 9.3e-17 60.6 0.8 2.0 2 0 0 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 ELR13775.1 - 1.8e-13 50.7 2.2 3.5e-05 24.2 0.2 3.2 2 2 0 2 2 2 2 Ubiquitin-like domain TBK1_ULD PF18396.1 ELR13775.1 - 1.7e-08 34.3 0.9 0.0053 16.6 0.1 2.2 2 0 0 2 2 2 2 TANK binding kinase 1 ubiquitin-like domain Ubiquitin_5 PF18037.1 ELR13775.1 - 3.4e-08 33.7 1.4 0.0076 16.6 0.1 2.1 1 1 0 2 2 2 2 Ubiquitin-like domain Rad60-SLD_2 PF13881.6 ELR13775.1 - 5.8e-08 32.8 0.7 0.017 15.2 0.1 2.8 2 2 0 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.9 ELR13775.1 - 6.8e-08 33.0 0.1 0.019 15.5 0.0 2.1 1 1 0 2 2 2 2 DUF2407 ubiquitin-like domain Ubiquitin_4 PF18036.1 ELR13775.1 - 2.4e-05 24.3 8.8 2.6 8.1 0.2 4.0 4 0 0 4 4 4 2 Ubiquitin-like domain Sde2_N_Ubi PF13019.6 ELR13775.1 - 7e-05 22.7 0.1 0.35 10.7 0.0 2.1 1 1 1 2 2 2 2 Silencing defective 2 N-terminal ubiquitin domain DUF3861 PF12977.7 ELR13775.1 - 0.00056 20.0 0.2 1.3 9.3 0.0 2.2 2 0 0 2 2 2 2 Domain of Unknown Function with PDB structure (DUF3861) ACT_5 PF13710.6 ELR13775.1 - 0.026 14.4 0.9 7.1 6.6 0.1 2.3 2 0 0 2 2 2 0 ACT domain DUF2870 PF11069.8 ELR13775.1 - 0.042 14.2 0.0 18 5.8 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2870) Big_3_3 PF13750.6 ELR13775.1 - 0.049 13.3 0.0 11 5.6 0.0 2.2 2 0 0 2 2 2 0 Bacterial Ig-like domain (group 3) Raf1_HTH PF18579.1 ELR13775.1 - 0.051 13.3 0.1 14 5.4 0.0 2.3 2 0 0 2 2 2 0 Rubisco accumulation factor 1 helix turn helix domain ACT_4 PF13291.6 ELR13775.1 - 0.093 13.3 0.1 24 5.6 0.0 2.3 2 0 0 2 2 2 0 ACT domain UN_NPL4 PF11543.8 ELR13775.1 - 0.094 13.2 0.2 19 5.8 0.0 2.3 2 0 0 2 2 2 0 Nuclear pore localisation protein NPL4 Plexin_cytopl PF08337.12 ELR13775.1 - 0.12 11.1 6.4 2.9 6.5 0.7 3.2 2 1 2 4 4 4 0 Plexin cytoplasmic RasGAP domain DUF493 PF04359.14 ELR13775.1 - 0.15 12.7 0.0 30 5.3 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF493) UDP-g_GGTase PF06427.11 ELR13775.1 - 0.16 12.1 1.2 1.4 9.0 0.1 2.4 3 0 0 3 3 3 0 UDP-glucose:Glycoprotein Glucosyltransferase DUF969 PF06149.12 ELR13775.1 - 0.17 11.3 0.0 6.1 6.2 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF969) PI3K_p85B PF02192.16 ELR13775.1 - 0.17 11.6 2.3 12 5.7 0.2 2.3 2 0 0 2 2 2 0 PI3-kinase family, p85-binding domain ProRS-C_2 PF09181.10 ELR13775.1 - 0.17 12.0 0.9 23 5.2 0.1 2.2 2 0 0 2 2 2 0 Prolyl-tRNA synthetase, C-terminal Tash_PEST PF07708.11 ELR13775.1 - 0.18 12.0 9.6 2.7 8.2 1.5 2.3 2 0 0 2 2 2 0 Tash protein PEST motif PITH PF06201.13 ELR13777.1 - 1.8e-44 151.6 0.0 2.2e-44 151.3 0.0 1.1 1 0 0 1 1 1 1 PITH domain MRP-S25 PF13741.6 ELR13778.1 - 0.032 13.8 0.1 0.032 13.8 0.1 2.5 3 0 0 3 3 3 0 Mitochondrial ribosomal protein S25 CBS PF00571.28 ELR13779.1 - 3.6e-16 59.4 3.4 1.3e-05 25.5 0.0 3.7 3 1 0 3 3 3 3 CBS domain Dimer_Tnp_hAT PF05699.14 ELR13779.1 - 0.0031 17.2 0.0 0.0085 15.9 0.0 1.7 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region HATPase_c PF02518.26 ELR13780.1 - 4.9e-49 165.5 0.3 3.2e-23 82.4 0.0 2.6 2 0 0 2 2 2 2 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 ELR13780.1 - 1e-39 135.2 0.1 5.7e-22 78.0 0.0 2.6 2 0 0 2 2 2 2 Response regulator receiver domain HisKA PF00512.25 ELR13780.1 - 5.8e-27 93.5 9.2 1.7e-13 50.4 0.6 3.2 3 0 0 3 3 3 2 His Kinase A (phospho-acceptor) domain PAS_4 PF08448.10 ELR13780.1 - 1.5e-19 70.2 0.0 6e-11 42.6 0.0 3.0 2 0 0 2 2 2 2 PAS fold PAS_9 PF13426.7 ELR13780.1 - 5.3e-07 29.8 0.0 0.00015 22.0 0.0 2.6 2 0 0 2 2 2 1 PAS domain PAS_8 PF13188.7 ELR13780.1 - 9.7e-06 25.5 0.0 3.7e-05 23.6 0.0 2.1 1 0 0 1 1 1 1 PAS domain PAS PF00989.25 ELR13780.1 - 0.00018 21.5 0.0 0.00043 20.3 0.0 1.6 1 0 0 1 1 1 1 PAS fold HATPase_c_3 PF13589.6 ELR13780.1 - 0.001 18.9 0.0 0.59 10.0 0.0 2.5 2 0 0 2 2 2 2 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase GAF_3 PF13492.6 ELR13780.1 - 0.0045 17.3 0.0 0.054 13.8 0.0 2.9 3 0 0 3 3 3 1 GAF domain GAF_2 PF13185.6 ELR13780.1 - 0.017 15.4 0.0 11 6.3 0.0 3.2 2 1 0 2 2 2 0 GAF domain Aminotran_3 PF00202.21 ELR13781.1 - 4.8e-127 424.0 0.0 5.7e-127 423.7 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III Aminotran_1_2 PF00155.21 ELR13781.1 - 0.0017 17.6 0.0 0.0069 15.6 0.0 1.8 2 0 0 2 2 2 1 Aminotransferase class I and II zf-PARP PF00645.18 ELR13782.1 - 2.2e-11 44.4 0.3 8.7e-11 42.5 0.3 2.1 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region XPA_C PF05181.12 ELR13782.1 - 0.0082 16.1 0.0 0.021 14.8 0.0 1.7 1 0 0 1 1 1 1 XPA protein C-terminus UPF0160 PF03690.13 ELR13782.1 - 0.013 15.1 0.4 0.024 14.3 0.4 1.4 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0160) ArfGap PF01412.18 ELR13782.1 - 0.066 13.3 0.3 0.066 13.3 0.3 2.3 3 0 0 3 3 3 0 Putative GTPase activating protein for Arf DZR PF12773.7 ELR13782.1 - 0.41 10.7 6.7 1.5 8.9 1.6 2.7 2 0 0 2 2 2 0 Double zinc ribbon Zn_ribbon_recom PF13408.6 ELR13782.1 - 3.7 8.1 10.6 4.8 7.8 0.7 3.2 3 0 0 3 3 3 0 Recombinase zinc beta ribbon domain RFXA_RFXANK_bdg PF15289.6 ELR13782.1 - 6 7.2 7.6 2.9 8.2 0.1 3.2 3 0 0 3 3 3 0 Regulatory factor X-associated C-terminal binding domain zf-dskA_traR PF01258.17 ELR13782.1 - 9.9 6.2 13.0 0.27 11.2 0.5 3.4 2 1 0 2 2 2 0 Prokaryotic dksA/traR C4-type zinc finger LANC_like PF05147.13 ELR13783.1 - 1.1e-51 175.4 0.0 1.5e-51 175.1 0.0 1.0 1 0 0 1 1 1 1 Lanthionine synthetase C-like protein TPR_7 PF13176.6 ELR13783.1 - 0.1 12.7 0.1 0.4 10.8 0.1 2.1 1 0 0 1 1 1 0 Tetratricopeptide repeat C5-epim_C PF06662.13 ELR13783.1 - 0.12 11.8 0.0 0.35 10.3 0.0 1.7 2 0 0 2 2 2 0 D-glucuronyl C5-epimerase C-terminus Profilin PF00235.19 ELR13784.1 - 3.9e-28 98.3 0.2 4.8e-28 98.0 0.2 1.1 1 0 0 1 1 1 1 Profilin SET PF00856.28 ELR13785.1 - 0.054 13.9 0.2 0.089 13.2 0.2 1.4 1 1 0 1 1 1 0 SET domain AAA_16 PF13191.6 ELR13786.1 - 9.5e-30 104.2 0.7 4.8e-29 101.9 0.0 2.7 2 0 0 2 2 2 1 AAA ATPase domain Pkinase PF00069.25 ELR13786.1 - 6.9e-21 74.8 0.0 2.4e-11 43.5 0.0 2.4 2 0 0 2 2 2 2 Protein kinase domain HisKA PF00512.25 ELR13786.1 - 1e-13 51.1 1.2 5.9e-13 48.7 0.1 2.9 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain Pkinase_Tyr PF07714.17 ELR13786.1 - 3.2e-12 46.3 0.0 3.1e-11 43.0 0.0 2.2 1 1 0 1 1 1 1 Protein tyrosine kinase HATPase_c PF02518.26 ELR13786.1 - 7.8e-10 39.3 0.3 4.3e-09 36.9 0.0 2.3 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase GAF PF01590.26 ELR13786.1 - 8.6e-08 32.9 0.1 5.3e-07 30.3 0.0 2.5 3 0 0 3 3 2 1 GAF domain AAA_PrkA PF08298.11 ELR13786.1 - 0.0053 15.7 0.0 0.0095 14.9 0.0 1.3 1 0 0 1 1 1 1 PrkA AAA domain RsgA_GTPase PF03193.16 ELR13786.1 - 0.0094 15.9 0.0 0.028 14.4 0.0 1.8 1 0 0 1 1 1 1 RsgA GTPase AAA_30 PF13604.6 ELR13786.1 - 0.017 14.9 0.0 0.043 13.5 0.0 1.7 1 0 0 1 1 1 0 AAA domain GAF_3 PF13492.6 ELR13786.1 - 0.02 15.3 0.0 2.2 8.6 0.0 2.7 2 0 0 2 2 2 0 GAF domain TRAF_BIRC3_bd PF16673.5 ELR13786.1 - 0.029 14.1 1.8 4.3 7.2 0.9 2.7 2 0 0 2 2 2 0 TNF receptor-associated factor BIRC3 binding domain DUF4423 PF14394.6 ELR13786.1 - 0.057 13.1 0.1 3.2 7.5 0.2 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4423) AAA_22 PF13401.6 ELR13786.1 - 0.094 13.0 0.0 0.5 10.6 0.0 2.3 1 0 0 1 1 1 0 AAA domain TPR_1 PF00515.28 ELR13786.1 - 2 8.4 4.1 14 5.7 0.3 3.1 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF4611 PF15387.6 ELR13786.1 - 8.9 6.6 12.0 31 4.9 0.1 3.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4611) Ras PF00071.22 ELR13791.1 - 9.8e-49 165.1 0.0 1.2e-48 164.7 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR13791.1 - 3.7e-28 98.2 0.0 5.9e-28 97.5 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR13791.1 - 5.5e-12 45.5 0.0 6.7e-12 45.2 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 ELR13791.1 - 0.00052 19.4 0.0 0.00064 19.1 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region PduV-EutP PF10662.9 ELR13791.1 - 0.0016 18.2 0.0 0.0051 16.6 0.0 1.7 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation SRPRB PF09439.10 ELR13791.1 - 0.006 16.0 0.0 0.008 15.6 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 ELR13791.1 - 0.0096 16.0 0.0 0.015 15.3 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_22 PF13401.6 ELR13791.1 - 0.013 15.8 0.1 0.32 11.3 0.1 2.3 1 1 0 1 1 1 0 AAA domain AAA_7 PF12775.7 ELR13791.1 - 0.21 11.1 0.0 0.41 10.2 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region Bactofilin PF04519.13 ELR13794.1 - 5.8e-15 55.4 77.7 2.7e-06 27.6 20.8 3.0 1 1 2 3 3 3 3 Polymer-forming cytoskeletal DUF3794 PF12673.7 ELR13794.1 - 0.0071 16.6 16.0 26 5.2 6.2 5.7 1 1 1 2 2 2 1 Domain of unknown function (DUF3794) DUF3494 PF11999.8 ELR13794.1 - 0.61 9.7 35.1 1.2 8.7 5.1 4.3 1 1 4 5 5 5 0 Protein of unknown function (DUF3494) Chorion_1 PF01723.16 ELR13794.1 - 1.6 8.7 35.9 7.7 6.5 11.2 3.9 1 1 2 3 3 3 0 Chorion protein DUF2572 PF10833.8 ELR13794.1 - 2.5 7.8 22.5 3.4 7.4 1.8 3.9 1 1 3 4 4 4 0 Protein of unknown function (DUF2572) F-box-like PF12937.7 ELR13796.1 - 1.2e-07 31.5 0.3 1.7e-07 31.0 0.3 1.2 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ELR13796.1 - 3.6e-05 23.5 0.3 8.9e-05 22.3 0.3 1.7 1 1 0 1 1 1 1 F-box domain Beta_helix PF13229.6 ELR13797.1 - 5.5e-13 49.1 37.8 5e-07 29.7 29.2 3.2 1 1 1 2 2 2 2 Right handed beta helix region Chondroitinas_B PF14592.6 ELR13797.1 - 0.028 13.3 0.1 0.028 13.3 0.1 2.4 2 1 0 2 2 2 0 Chondroitinase B Astacin PF01400.24 ELR13799.1 - 0.19 11.3 0.4 0.21 11.2 0.4 1.1 1 0 0 1 1 1 0 Astacin (Peptidase family M12A) SKG6 PF08693.10 ELR13802.1 - 3 7.3 13.9 0.82 9.1 10.5 1.8 1 1 1 2 2 2 0 Transmembrane alpha-helix domain Pkinase_Tyr PF07714.17 ELR13804.1 - 3.2e-40 138.1 1.9 5.2e-40 137.4 0.1 2.1 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.25 ELR13804.1 - 6.7e-37 127.3 0.0 1.2e-36 126.5 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Guanylate_cyc PF00211.20 ELR13804.1 - 0.09 12.4 0.2 0.19 11.3 0.2 1.5 1 1 0 1 1 1 0 Adenylate and Guanylate cyclase catalytic domain Pkinase_Tyr PF07714.17 ELR13805.1 - 1.7e-29 102.9 0.1 2.2e-29 102.5 0.1 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ELR13805.1 - 1e-27 97.2 0.1 1.3e-27 96.9 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain EGF_2 PF07974.13 ELR13805.1 - 8.5e-05 22.8 8.1 0.00017 21.9 8.1 1.5 1 0 0 1 1 1 1 EGF-like domain EGF PF00008.27 ELR13805.1 - 0.00014 22.1 4.1 0.00028 21.1 4.1 1.6 1 0 0 1 1 1 1 EGF-like domain EGF_alliinase PF04863.13 ELR13805.1 - 0.0074 16.7 3.2 0.013 15.9 3.2 1.3 1 0 0 1 1 1 1 Alliinase EGF-like domain hEGF PF12661.7 ELR13805.1 - 0.042 14.5 4.1 0.23 12.2 4.1 2.3 1 1 0 1 1 1 0 Human growth factor-like EGF FTA2 PF13095.6 ELR13805.1 - 0.14 11.7 0.0 9.7 5.7 0.0 2.1 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 DUF2381 PF09544.10 ELR13806.1 - 0.014 14.9 0.5 0.019 14.5 0.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2381) DivIC PF04977.15 ELR13806.1 - 0.085 12.6 3.7 0.14 12.0 3.7 1.3 1 0 0 1 1 1 0 Septum formation initiator ZapB PF06005.12 ELR13806.1 - 0.25 11.8 4.1 0.44 11.0 4.1 1.3 1 0 0 1 1 1 0 Cell division protein ZapB Thymidylat_synt PF00303.19 ELR13809.1 - 6.1e-19 68.2 0.0 6.7e-19 68.1 0.0 1.0 1 0 0 1 1 1 1 Thymidylate synthase SWIM PF04434.17 ELR13810.1 - 0.0089 15.7 0.3 0.02 14.6 0.3 1.5 1 0 0 1 1 1 1 SWIM zinc finger DUF2157 PF09925.9 ELR13811.1 - 0.016 15.0 0.2 0.51 10.1 0.0 2.1 2 0 0 2 2 2 0 Predicted membrane protein (DUF2157) DUF4079 PF13301.6 ELR13811.1 - 0.028 14.6 0.6 2.6 8.2 0.6 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF4079) DUF948 PF06103.11 ELR13811.1 - 0.049 13.9 0.1 0.079 13.2 0.1 1.3 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF948) Antimicrobial10 PF08105.11 ELR13811.1 - 1.7 8.8 5.0 3.3 7.9 1.3 2.6 2 0 0 2 2 2 0 Metchnikowin family CRF1 PF10380.9 ELR13812.1 - 0.018 15.3 0.1 0.032 14.6 0.1 1.4 1 1 0 1 1 1 0 Transcription factor CRF1 Invasin_D3 PF09134.10 ELR13816.1 - 0.1 12.9 0.1 0.13 12.5 0.1 1.1 1 0 0 1 1 1 0 Invasin, domain 3 Bactofilin PF04519.13 ELR13818.1 - 2.3e-06 27.8 10.4 3.1e-06 27.4 10.4 1.1 1 0 0 1 1 1 1 Polymer-forming cytoskeletal T2SSB PF16537.5 ELR13818.1 - 0.17 11.5 2.5 13 5.5 0.4 3.1 1 1 2 3 3 3 0 Type II secretion system protein B DUF3794 PF12673.7 ELR13818.1 - 0.2 11.9 0.9 4.1 7.8 0.9 2.5 1 1 0 1 1 1 0 Domain of unknown function (DUF3794) Chorion_1 PF01723.16 ELR13818.1 - 2.7 7.9 11.4 5 7.1 4.9 2.1 1 1 1 2 2 2 0 Chorion protein Ank PF00023.30 ELR13819.1 - 2.8e-09 37.0 2.7 2.1e-06 27.9 0.1 2.7 2 0 0 2 2 2 2 Ankyrin repeat Ank_2 PF12796.7 ELR13819.1 - 3e-09 37.3 0.2 7.6e-06 26.4 0.0 2.4 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 ELR13819.1 - 9.6e-09 34.8 0.7 0.00055 20.2 0.0 3.0 3 0 0 3 3 3 2 Ankyrin repeat Ank_4 PF13637.6 ELR13819.1 - 3.4e-08 33.9 0.1 0.00012 22.6 0.0 2.6 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 ELR13819.1 - 7.8e-08 32.4 0.7 0.00012 22.3 0.0 2.5 2 0 0 2 2 2 2 Ankyrin repeats (many copies) F-box-like PF12937.7 ELR13819.1 - 4e-07 29.8 0.2 7.1e-07 29.0 0.2 1.4 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ELR13819.1 - 2.5e-06 27.2 0.7 4.4e-06 26.4 0.7 1.5 1 0 0 1 1 1 1 F-box domain F-box_4 PF15966.5 ELR13819.1 - 4.7e-06 26.5 0.1 9.8e-06 25.4 0.1 1.5 1 0 0 1 1 1 1 F-box GMC_oxred_N PF00732.19 ELR13821.1 - 1.6e-53 182.0 0.0 2.3e-53 181.5 0.0 1.1 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 ELR13821.1 - 7.3e-23 81.7 0.0 1.1e-10 42.2 0.0 2.4 1 1 1 2 2 2 2 GMC oxidoreductase Lycopene_cycl PF05834.12 ELR13821.1 - 1.9e-05 23.9 0.1 3.1e-05 23.2 0.1 1.3 1 0 0 1 1 1 1 Lycopene cyclase protein NAD_binding_8 PF13450.6 ELR13821.1 - 0.00049 20.3 0.1 0.00049 20.3 0.1 2.2 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 ELR13821.1 - 0.0011 18.6 0.0 0.0023 17.6 0.0 1.7 2 0 0 2 2 2 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 ELR13821.1 - 0.0018 17.5 0.0 0.0031 16.6 0.0 1.5 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 ELR13821.1 - 0.011 15.0 0.0 0.02 14.2 0.0 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 ELR13821.1 - 0.038 13.2 0.0 0.077 12.2 0.0 1.4 1 0 0 1 1 1 0 Thi4 family HI0933_like PF03486.14 ELR13821.1 - 0.084 11.6 0.0 0.15 10.8 0.0 1.3 1 0 0 1 1 1 0 HI0933-like protein Abhydrolase_6 PF12697.7 ELR13821.1 - 0.11 13.1 2.0 0.17 12.5 1.3 1.7 2 0 0 2 2 2 0 Alpha/beta hydrolase family FAM70 PF14967.6 ELR13822.1 - 0.024 14.1 2.1 0.029 13.9 2.1 1.0 1 0 0 1 1 1 0 FAM70 protein Neisseria_TspB PF05616.13 ELR13822.1 - 0.68 8.3 4.8 0.75 8.2 4.8 1.0 1 0 0 1 1 1 0 Neisseria meningitidis TspB protein UL2 PF08196.11 ELR13822.1 - 1 9.4 7.3 6.5 6.8 0.2 3.1 2 1 1 3 3 3 0 UL2 protein ORC6 PF05460.13 ELR13822.1 - 4.9 6.3 5.6 5.3 6.2 5.6 1.1 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) Filamin PF00630.19 ELR13824.1 - 2.3e-54 182.6 6.5 1.2e-18 67.8 0.0 5.2 4 2 0 4 4 4 3 Filamin/ABP280 repeat BTB PF00651.31 ELR13824.1 - 7.4e-36 122.8 4.0 1.7e-25 89.4 0.2 3.4 2 1 1 3 3 3 3 BTB/POZ domain RCC1 PF00415.18 ELR13824.1 - 3.5e-31 107.6 14.5 4.1e-12 46.5 0.5 5.5 6 0 0 6 6 6 3 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 ELR13824.1 - 8.4e-11 41.4 24.1 2.7e-05 23.8 0.5 5.8 6 0 0 6 6 6 3 Regulator of chromosome condensation (RCC1) repeat BACK PF07707.15 ELR13824.1 - 0.00097 19.2 1.8 0.0023 18.0 0.3 2.2 2 0 0 2 2 2 1 BTB And C-terminal Kelch zf-RanBP PF00641.18 ELR13824.1 - 0.012 14.9 1.2 0.026 13.8 1.2 1.6 1 0 0 1 1 1 0 Zn-finger in Ran binding protein and others PhnA_Zn_Ribbon PF08274.12 ELR13824.1 - 0.15 12.1 0.5 0.32 11.0 0.5 1.5 1 0 0 1 1 1 0 PhnA Zinc-Ribbon DUF4213 PF13938.6 ELR13824.1 - 0.77 10.0 3.7 13 6.1 0.1 4.0 4 1 1 5 5 5 0 Putative heavy-metal chelation AMP-binding PF00501.28 ELR13825.1 - 9.3e-47 159.6 2.1 1.7e-36 125.8 0.0 2.7 2 1 0 2 2 2 2 AMP-binding enzyme AMP-binding_C PF13193.6 ELR13825.1 - 1e-05 26.4 0.9 3.6e-05 24.7 0.1 2.2 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain DUF647 PF04884.14 ELR13825.1 - 0.00031 20.5 0.2 0.00067 19.3 0.2 1.5 1 0 0 1 1 1 1 Vitamin B6 photo-protection and homoeostasis MCR PF18509.1 ELR13825.1 - 0.094 12.3 0.8 0.19 11.3 0.0 2.0 2 0 0 2 2 2 0 Magnetochrome domain Peptidase_U40 PF10464.9 ELR13825.1 - 0.14 11.8 0.2 0.31 10.7 0.2 1.5 1 0 0 1 1 1 0 Peptidase U40 XRN_M PF17846.1 ELR13826.1 - 1.1e-144 482.7 0.0 8.1e-143 476.5 0.0 2.2 1 1 0 1 1 1 1 Xrn1 helical domain XRN_N PF03159.18 ELR13826.1 - 2.3e-56 190.9 0.0 2.3e-56 190.9 0.0 1.9 2 0 0 2 2 2 1 XRN 5'-3' exonuclease N-terminus zf-CCHC PF00098.23 ELR13826.1 - 5.7e-06 26.2 1.1 1.3e-05 25.0 1.1 1.6 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_2 PF13696.6 ELR13826.1 - 0.0047 16.7 0.8 0.011 15.5 0.8 1.6 1 0 0 1 1 1 1 Zinc knuckle ABC2_membrane PF01061.24 ELR13827.1 - 5.6e-35 120.7 21.9 8.5e-21 74.3 3.6 2.2 1 1 1 2 2 2 2 ABC-2 type transporter ABC_tran PF00005.27 ELR13827.1 - 9.6e-27 94.2 0.0 1.6e-26 93.4 0.0 1.4 1 0 0 1 1 1 1 ABC transporter RsgA_GTPase PF03193.16 ELR13827.1 - 0.0041 17.0 1.2 0.0064 16.4 0.2 1.8 2 0 0 2 2 1 1 RsgA GTPase AAA_29 PF13555.6 ELR13827.1 - 0.0045 16.7 1.3 0.0067 16.1 0.2 1.8 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_21 PF13304.6 ELR13827.1 - 0.0052 16.6 0.1 0.12 12.1 0.0 2.2 2 0 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_16 PF13191.6 ELR13827.1 - 0.0095 16.3 0.0 0.022 15.1 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain ABC2_membrane_3 PF12698.7 ELR13827.1 - 0.018 14.2 19.7 0.045 12.9 19.7 1.8 1 1 0 1 1 1 0 ABC-2 family transporter protein AAA_25 PF13481.6 ELR13827.1 - 0.031 13.8 0.0 0.054 13.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 ELR13827.1 - 0.036 14.6 0.1 0.17 12.4 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_28 PF13521.6 ELR13827.1 - 0.05 13.9 0.1 0.11 12.8 0.1 1.6 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 ELR13827.1 - 0.053 13.4 0.4 0.11 12.4 0.4 1.5 1 0 0 1 1 1 0 NACHT domain AAA_33 PF13671.6 ELR13827.1 - 0.068 13.3 0.0 0.14 12.3 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 ELR13827.1 - 0.093 13.0 0.0 0.17 12.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_23 PF13476.6 ELR13827.1 - 0.093 13.2 0.0 0.21 12.0 0.0 1.6 1 0 0 1 1 1 0 AAA domain cobW PF02492.19 ELR13827.1 - 0.23 11.0 0.1 0.39 10.3 0.1 1.3 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain SIR2 PF02146.17 ELR13828.1 - 8.3e-28 97.5 0.0 1.2e-21 77.5 0.0 2.4 1 1 1 2 2 2 2 Sir2 family TPP_enzyme_M PF00205.22 ELR13828.1 - 0.0096 15.7 0.1 1.5 8.6 0.0 2.3 2 0 0 2 2 2 2 Thiamine pyrophosphate enzyme, central domain Pkinase_Tyr PF07714.17 ELR13829.1 - 4e-110 367.2 0.0 7.8e-60 202.3 0.0 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 ELR13829.1 - 1.6e-95 319.4 0.0 1.6e-52 178.5 0.0 2.3 2 0 0 2 2 2 2 Protein kinase domain PBP_like_2 PF12849.7 ELR13829.1 - 3.8e-34 118.6 7.2 1.2e-19 71.1 0.8 2.2 2 0 0 2 2 2 2 PBP superfamily domain Guanylate_cyc PF00211.20 ELR13829.1 - 1.1e-15 57.8 0.0 2e-15 56.9 0.0 1.3 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain APH PF01636.23 ELR13829.1 - 3.4e-07 30.5 1.8 5.7e-05 23.1 0.3 2.5 2 0 0 2 2 2 2 Phosphotransferase enzyme family EGF_2 PF07974.13 ELR13829.1 - 0.00021 21.6 10.2 0.00039 20.7 10.2 1.5 1 0 0 1 1 1 1 EGF-like domain Kdo PF06293.14 ELR13829.1 - 0.00033 20.1 0.3 0.75 9.1 0.0 2.3 2 0 0 2 2 2 2 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 ELR13829.1 - 0.00048 19.2 0.0 0.049 12.6 0.0 2.4 3 0 0 3 3 3 1 Haspin like kinase domain Kinase-like PF14531.6 ELR13829.1 - 0.00089 18.7 0.0 0.16 11.2 0.0 2.2 2 0 0 2 2 2 2 Kinase-like Pkinase_fungal PF17667.1 ELR13829.1 - 0.0038 16.1 0.0 1 8.1 0.0 2.2 2 0 0 2 2 2 2 Fungal protein kinase Stevor PF17410.2 ELR13829.1 - 0.14 11.7 0.0 0.24 10.9 0.0 1.3 1 0 0 1 1 1 0 Subtelomeric Variable Open Reading frame RIO1 PF01163.22 ELR13829.1 - 0.22 11.1 0.2 23 4.5 0.0 2.3 2 0 0 2 2 2 0 RIO1 family Myb_DNA-binding PF00249.31 ELR13830.1 - 3.6e-08 33.5 0.0 3.1e-07 30.5 0.0 2.1 2 0 0 2 2 2 1 Myb-like DNA-binding domain TP2 PF01254.18 ELR13830.1 - 0.046 14.3 0.4 0.064 13.9 0.4 1.1 1 0 0 1 1 1 0 Nuclear transition protein 2 RasGEF_N PF00618.20 ELR13831.1 - 2.3e-14 53.5 0.3 4.4e-12 46.2 0.3 2.2 1 1 0 1 1 1 1 RasGEF N-terminal motif RasGEF PF00617.19 ELR13832.1 - 9.3e-49 166.0 0.6 1.4e-48 165.4 0.6 1.3 1 0 0 1 1 1 1 RasGEF domain La PF05383.17 ELR13833.1 - 1.5e-19 69.8 0.1 2.6e-19 69.0 0.1 1.4 1 0 0 1 1 1 1 La domain RRM_1 PF00076.22 ELR13833.1 - 1.4e-17 63.3 0.4 8.7e-14 51.1 0.1 2.6 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 ELR13833.1 - 9e-11 41.7 10.3 7e-09 35.7 0.1 2.8 1 1 0 2 2 2 2 RNA binding motif RRM_7 PF16367.5 ELR13833.1 - 0.016 15.3 0.0 0.037 14.2 0.0 1.6 1 0 0 1 1 1 0 RNA recognition motif Plk4_PB1 PF18190.1 ELR13833.1 - 0.09 13.0 0.3 0.54 10.4 0.3 2.2 2 0 0 2 2 2 0 Polo-like Kinase 4 Polo Box 1 Peptidase_U57 PF05582.12 ELR13833.1 - 0.1 11.8 2.6 0.19 11.0 2.6 1.4 1 0 0 1 1 1 0 YabG peptidase U57 Tho2 PF11262.8 ELR13833.1 - 6.3 5.9 11.8 1.9 7.6 6.0 2.0 2 0 0 2 2 2 0 Transcription factor/nuclear export subunit protein 2 GATA PF00320.27 ELR13834.1 - 5.8e-17 61.0 2.4 5.8e-17 61.0 2.4 1.8 2 0 0 2 2 2 1 GATA zinc finger CAF20 PF17052.5 ELR13834.1 - 0.013 15.6 0.9 0.027 14.6 0.9 1.4 1 0 0 1 1 1 0 Cap associated factor tRNA-synt_2c PF01411.19 ELR13835.1 - 5.3e-214 711.8 0.0 6.8e-214 711.4 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (A) DHHA1 PF02272.19 ELR13835.1 - 5.7e-12 46.2 5.5 5.7e-12 46.2 5.5 2.4 1 1 1 2 2 2 1 DHHA1 domain tRNA_SAD PF07973.14 ELR13835.1 - 6.7e-10 38.9 0.0 1.5e-09 37.8 0.0 1.6 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain DUF1840 PF08895.11 ELR13835.1 - 0.14 12.5 7.0 2 8.8 0.4 2.7 1 1 1 2 2 2 0 Domain of unknown function (DUF1840) RasGEF PF00617.19 ELR13836.1 - 7.8e-46 156.5 0.2 4.2e-45 154.1 0.2 1.9 1 1 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 ELR13836.1 - 2.4e-06 27.7 0.1 5.2e-06 26.6 0.1 1.6 1 0 0 1 1 1 1 RasGEF N-terminal motif DUF4264 PF14084.6 ELR13836.1 - 0.056 13.1 0.1 0.13 12.0 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4264) DUF3784 PF12650.7 ELR13838.1 - 0.095 12.9 0.1 0.095 12.9 0.1 2.8 1 1 0 2 2 2 0 Domain of unknown function (DUF3784) Tmpp129 PF10272.9 ELR13838.1 - 0.18 11.1 2.1 0.27 10.5 2.1 1.2 1 0 0 1 1 1 0 Putative transmembrane protein precursor E1-E2_ATPase PF00122.20 ELR13838.1 - 0.73 9.3 8.9 0.44 10.0 5.7 1.9 2 0 0 2 2 2 0 E1-E2 ATPase DHHC PF01529.20 ELR13838.1 - 4 7.5 12.0 20 5.3 7.2 2.4 1 1 1 2 2 2 0 DHHC palmitoyltransferase SPRY PF00622.28 ELR13839.1 - 2.3e-17 63.2 0.1 4.7e-17 62.2 0.1 1.5 1 0 0 1 1 1 1 SPRY domain Neuralized PF07177.12 ELR13839.1 - 1.3e-05 25.2 0.0 4.5e-05 23.5 0.0 1.8 1 1 0 1 1 1 1 Neuralized BACK PF07707.15 ELR13839.1 - 0.00035 20.6 1.7 0.0048 17.0 0.1 2.7 3 0 0 3 3 3 1 BTB And C-terminal Kelch CCDC50_N PF15295.6 ELR13839.1 - 0.0032 17.6 4.7 0.0053 16.9 3.5 2.0 2 0 0 2 2 2 1 Coiled-coil domain-containing protein 50 N-terminus SPATA24 PF15175.6 ELR13839.1 - 2.2 8.2 9.8 0.16 11.9 1.1 2.6 3 0 0 3 3 3 0 Spermatogenesis-associated protein 24 ABC_membrane PF00664.23 ELR13840.1 - 3.5e-74 249.9 21.0 2.6e-42 145.4 3.3 2.9 2 1 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 ELR13840.1 - 1.3e-46 158.5 0.0 2.6e-22 79.8 0.0 2.8 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 ELR13840.1 - 1.2e-08 34.7 0.7 0.005 16.3 0.0 3.3 2 1 1 3 3 3 2 RecF/RecN/SMC N terminal domain MTABC_N PF16185.5 ELR13840.1 - 7e-06 25.7 3.9 2e-05 24.2 3.9 1.7 1 0 0 1 1 1 1 Mitochondrial ABC-transporter N-terminal five TM region CDC45 PF02724.14 ELR13840.1 - 3.4e-05 22.3 5.6 3.4e-05 22.3 5.6 1.5 2 0 0 2 2 2 1 CDC45-like protein Dynamin_N PF00350.23 ELR13840.1 - 0.0016 18.5 0.2 0.017 15.2 0.0 2.5 2 0 0 2 2 2 1 Dynamin family AAA_16 PF13191.6 ELR13840.1 - 0.0016 18.8 0.1 0.0057 17.1 0.0 1.9 2 0 0 2 2 2 1 AAA ATPase domain MMR_HSR1 PF01926.23 ELR13840.1 - 0.0059 16.7 1.5 0.022 14.8 0.0 2.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_15 PF13175.6 ELR13840.1 - 0.011 15.5 0.1 0.018 14.8 0.1 1.3 1 0 0 1 1 1 0 AAA ATPase domain AAA_29 PF13555.6 ELR13840.1 - 0.024 14.4 1.1 0.15 11.8 0.1 2.3 2 0 0 2 2 2 0 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 ELR13840.1 - 0.064 13.1 2.8 0.065 13.1 0.4 2.2 2 1 0 2 2 1 0 RsgA GTPase T2SSE PF00437.20 ELR13840.1 - 0.068 12.2 0.0 0.2 10.7 0.0 1.7 2 0 0 2 2 2 0 Type II/IV secretion system protein PHO4 PF01384.20 ELR13840.1 - 0.085 11.9 0.2 6.9 5.6 0.0 3.1 2 2 0 3 3 3 0 Phosphate transporter family AAA_25 PF13481.6 ELR13840.1 - 0.11 12.1 0.0 0.22 11.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain Zeta_toxin PF06414.12 ELR13840.1 - 0.3 10.3 1.6 0.33 10.2 0.1 1.8 2 0 0 2 2 2 0 Zeta toxin DUF87 PF01935.17 ELR13840.1 - 0.82 9.7 5.0 2.3 8.3 0.5 2.5 2 0 0 2 2 2 0 Helicase HerA, central domain TFIIF_alpha PF05793.12 ELR13840.1 - 2.1 6.8 24.9 3.9 5.9 24.9 1.3 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) AAA_21 PF13304.6 ELR13840.1 - 2.2 8.0 6.0 0.32 10.8 0.1 2.6 3 0 0 3 3 3 0 AAA domain, putative AbiEii toxin, Type IV TA system LNP1 PF15419.6 ELR13841.1 - 0.048 13.9 0.6 0.057 13.6 0.6 1.1 1 0 0 1 1 1 0 Leukemia NUP98 fusion partner 1 Glyco_hydro_1 PF00232.18 ELR13841.1 - 0.1 11.0 0.0 0.11 10.9 0.0 1.0 1 0 0 1 1 1 0 Glycosyl hydrolase family 1 RR_TM4-6 PF06459.12 ELR13842.1 - 1 9.1 23.9 1.6 8.5 1.4 3.3 3 0 0 3 3 3 0 Ryanodine Receptor TM 4-6 TPT PF03151.16 ELR13844.1 - 1.2e-16 60.9 12.0 2.1e-16 60.1 12.0 1.3 1 1 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 ELR13844.1 - 0.013 15.7 28.9 0.02 15.1 9.9 3.1 2 1 0 2 2 2 0 EamA-like transporter family FAM176 PF14851.6 ELR13844.1 - 0.65 9.6 2.3 0.71 9.5 0.2 2.1 2 0 0 2 2 2 0 FAM176 family DUF2374 PF09574.10 ELR13844.1 - 1.1 9.1 5.4 17 5.3 0.4 2.9 2 0 0 2 2 2 0 Protein of unknown function (Duf2374) DUF3367 PF11847.8 ELR13844.1 - 9.7 3.9 11.3 5.6 4.7 1.2 2.1 2 0 0 2 2 2 0 Alpha-(1->3)-arabinofuranosyltransferase TIP49 PF06068.13 ELR13845.1 - 9.9e-155 515.0 0.8 9.9e-155 515.0 0.8 1.5 1 1 1 2 2 2 1 TIP49 P-loop domain TIP49_C PF17856.1 ELR13845.1 - 1.3e-24 86.1 1.4 3.6e-24 84.7 1.4 1.9 1 0 0 1 1 1 1 TIP49 AAA-lid domain AAA PF00004.29 ELR13845.1 - 1e-07 32.4 4.5 2.7e-05 24.6 0.1 3.2 3 1 0 3 3 3 2 ATPase family associated with various cellular activities (AAA) DnaB_C PF03796.15 ELR13845.1 - 1.3e-05 24.7 0.2 3e-05 23.5 0.2 1.6 1 0 0 1 1 1 1 DnaB-like helicase C terminal domain RuvB_N PF05496.12 ELR13845.1 - 1.5e-05 24.8 0.4 0.0074 16.0 0.1 2.4 2 0 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_5 PF07728.14 ELR13845.1 - 6.9e-05 22.9 0.7 0.0038 17.2 0.0 3.1 3 1 1 4 4 3 1 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.21 ELR13845.1 - 0.00014 21.4 0.8 0.0012 18.3 0.3 2.2 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_16 PF13191.6 ELR13845.1 - 0.00026 21.4 0.1 0.00069 20.0 0.1 1.8 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 ELR13845.1 - 0.00035 20.9 0.3 0.45 10.8 0.1 2.4 1 1 1 2 2 2 2 AAA domain Sigma54_activat PF00158.26 ELR13845.1 - 0.00046 19.9 0.1 0.29 10.8 0.1 2.6 2 0 0 2 2 2 2 Sigma-54 interaction domain ATPase PF06745.13 ELR13845.1 - 0.00097 18.5 0.1 0.0022 17.4 0.1 1.7 1 0 0 1 1 1 1 KaiC AAA_19 PF13245.6 ELR13845.1 - 0.0011 19.3 3.4 0.0013 19.1 0.8 2.4 2 1 0 2 2 2 1 AAA domain AAA_25 PF13481.6 ELR13845.1 - 0.0016 18.0 0.1 0.018 14.6 0.1 2.2 2 0 0 2 2 2 1 AAA domain Zeta_toxin PF06414.12 ELR13845.1 - 0.0061 15.9 0.2 0.015 14.6 0.2 1.6 1 0 0 1 1 1 1 Zeta toxin AAA_7 PF12775.7 ELR13845.1 - 0.0083 15.7 0.4 0.041 13.4 0.0 2.2 3 0 0 3 3 3 1 P-loop containing dynein motor region DUF2075 PF09848.9 ELR13845.1 - 0.023 13.9 0.0 0.038 13.2 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_11 PF13086.6 ELR13845.1 - 0.04 13.7 0.1 0.09 12.5 0.1 1.6 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 ELR13845.1 - 0.054 13.4 0.0 0.11 12.4 0.0 1.5 1 0 0 1 1 1 0 NACHT domain Sigma54_activ_2 PF14532.6 ELR13845.1 - 0.11 12.6 0.0 1.7 8.8 0.0 2.6 3 0 0 3 3 3 0 Sigma-54 interaction domain ResIII PF04851.15 ELR13845.1 - 0.16 12.0 0.4 4.1 7.4 0.2 2.3 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit AAA_29 PF13555.6 ELR13845.1 - 0.18 11.6 0.1 2 8.2 0.1 2.4 2 0 0 2 2 2 0 P-loop containing region of AAA domain TsaE PF02367.17 ELR13845.1 - 0.29 11.1 1.8 0.57 10.2 0.2 2.2 2 1 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_30 PF13604.6 ELR13845.1 - 0.38 10.4 3.0 2.3 7.9 1.7 2.4 2 1 0 2 2 2 0 AAA domain Aminotran_5 PF00266.19 ELR13846.1 - 1.3e-24 86.9 0.0 1.5e-24 86.6 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-V B12-binding PF02310.19 ELR13846.1 - 0.0022 18.1 0.3 0.076 13.0 0.0 2.4 2 0 0 2 2 2 1 B12 binding domain AMP-binding PF00501.28 ELR13849.1 - 2.7e-78 263.5 0.1 3.1e-76 256.7 0.0 2.2 2 0 0 2 2 2 2 AMP-binding enzyme AMP-binding_C PF13193.6 ELR13849.1 - 4.7e-23 82.0 0.5 1.1e-22 80.8 0.5 1.7 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain ACAS_N PF16177.5 ELR13849.1 - 2.8e-21 75.2 2.0 2.8e-21 75.2 2.0 2.1 2 0 0 2 2 2 1 Acetyl-coenzyme A synthetase N-terminus C2 PF00168.30 ELR13850.1 - 1.5e-13 50.9 0.0 2.8e-13 50.0 0.0 1.5 1 0 0 1 1 1 1 C2 domain LOR PF04525.12 ELR13850.1 - 0.066 12.8 0.0 0.11 12.1 0.0 1.3 1 0 0 1 1 1 0 LURP-one-related DUF2207 PF09972.9 ELR13851.1 - 8.5 5.0 7.0 10 4.7 7.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF3217 PF11506.8 ELR13852.1 - 0.031 14.2 0.0 0.059 13.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3217) HNOB PF07700.15 ELR13854.1 - 1.3e-36 126.1 0.0 2.7e-36 125.0 0.0 1.6 1 0 0 1 1 1 1 Haem-NO-binding HNOBA PF07701.14 ELR13854.1 - 7.3e-26 91.0 1.0 4.3e-12 45.9 0.0 2.7 2 1 1 3 3 3 2 Heme NO binding associated RasGAP PF00616.19 ELR13854.1 - 2.9e-14 53.3 0.0 3.6e-08 33.4 0.0 2.3 1 1 1 2 2 2 2 GTPase-activator protein for Ras-like GTPase HD_assoc PF13286.6 ELR13854.1 - 0.038 14.5 0.1 0.31 11.6 0.0 2.4 2 1 1 3 3 3 0 Phosphohydrolase-associated domain EMP70 PF02990.16 ELR13855.1 - 3e-158 527.7 15.7 4.2e-158 527.3 15.7 1.2 1 0 0 1 1 1 1 Endomembrane protein 70 CorA PF01544.18 ELR13855.1 - 0.012 14.9 0.1 0.012 14.9 0.1 2.3 3 0 0 3 3 3 0 CorA-like Mg2+ transporter protein DUF3817 PF12823.7 ELR13855.1 - 0.057 14.2 0.1 0.057 14.2 0.1 4.3 3 1 0 3 3 3 0 Domain of unknown function (DUF3817) Tmemb_18A PF09771.9 ELR13855.1 - 2.6 8.5 4.5 13 6.2 1.3 2.7 2 0 0 2 2 2 0 Transmembrane protein 188 Ras PF00071.22 ELR13856.1 - 6.9e-47 159.0 0.3 8.2e-47 158.8 0.3 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR13856.1 - 1.2e-20 73.9 0.1 2.7e-20 72.8 0.1 1.6 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR13856.1 - 6.2e-12 45.3 0.0 8.5e-12 44.9 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 ELR13856.1 - 0.04 13.5 0.1 0.12 11.9 0.1 1.6 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain BBS2_N PF14781.6 ELR13856.1 - 0.071 13.0 0.1 0.19 11.6 0.0 1.8 2 0 0 2 2 2 0 Ciliary BBSome complex subunit 2, N-terminal Gtr1_RagA PF04670.12 ELR13856.1 - 0.12 11.7 0.0 0.13 11.6 0.0 1.2 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region F-box-like PF12937.7 ELR13857.1 - 0.0024 17.8 1.2 0.0081 16.0 1.2 1.9 1 1 0 1 1 1 1 F-box-like NOA36 PF06524.12 ELR13857.1 - 0.012 14.9 4.3 0.016 14.5 4.3 1.1 1 0 0 1 1 1 0 NOA36 protein F-box PF00646.33 ELR13857.1 - 0.082 12.8 1.6 0.22 11.4 0.5 2.2 2 0 0 2 2 2 0 F-box domain MORN PF02493.20 ELR13858.1 - 3.1e-48 158.9 64.6 5.1e-06 26.1 0.1 13.7 13 0 0 13 13 13 13 MORN repeat RhoGEF PF00621.20 ELR13858.1 - 2.2e-39 135.6 1.3 3.1e-39 135.1 1.3 1.2 1 0 0 1 1 1 1 RhoGEF domain PH_13 PF16652.5 ELR13858.1 - 0.062 13.1 0.0 0.12 12.2 0.0 1.4 1 0 0 1 1 1 0 Pleckstrin homology domain PH_16 PF17838.1 ELR13858.1 - 0.091 12.6 0.1 0.5 10.2 0.0 2.0 2 0 0 2 2 2 0 PH domain Atg14 PF10186.9 ELR13859.1 - 0.0015 17.7 22.8 0.0015 17.7 22.8 5.5 4 1 1 5 5 5 1 Vacuolar sorting 38 and autophagy-related subunit 14 ERM PF00769.19 ELR13859.1 - 0.0069 16.2 42.8 0.0069 16.2 42.8 6.1 2 2 2 5 5 5 1 Ezrin/radixin/moesin family NPV_P10 PF05531.12 ELR13859.1 - 6.3 7.3 6.6 27 5.3 1.4 2.9 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein RRM_1 PF00076.22 ELR13860.1 - 5.2e-17 61.4 0.0 7.6e-17 60.9 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) G_glu_transpept PF01019.21 ELR13863.1 - 0.14 10.9 0.0 0.17 10.6 0.0 1.1 1 0 0 1 1 1 0 Gamma-glutamyltranspeptidase Folate_rec PF03024.14 ELR13864.1 - 2.4e-06 27.5 16.2 3e-06 27.2 16.2 1.2 1 0 0 1 1 1 1 Folate receptor family Cupin_8 PF13621.6 ELR13865.1 - 2.5e-12 47.1 0.0 7.2e-12 45.6 0.0 1.7 1 1 0 1 1 1 1 Cupin-like domain Mpv17_PMP22 PF04117.12 ELR13866.1 - 5.8e-21 74.5 0.5 5.8e-21 74.5 0.5 1.7 2 0 0 2 2 2 1 Mpv17 / PMP22 family DUF1029 PF06269.12 ELR13868.1 - 2 8.6 23.9 5.5 7.2 1.6 4.5 1 1 3 4 4 4 0 Protein of unknown function (DUF1029) DUF4479 PF14794.6 ELR13869.1 - 0.049 13.5 0.1 0.093 12.6 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4479) Abhydrolase_1 PF00561.20 ELR13870.1 - 1.6e-13 50.9 0.0 1.5e-07 31.4 0.1 2.2 1 1 0 2 2 2 2 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 ELR13870.1 - 5.3e-12 45.5 0.1 4e-11 42.6 0.1 2.0 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 ELR13870.1 - 3.4e-06 27.8 0.1 2.9e-05 24.8 0.1 2.3 1 1 0 1 1 1 1 Alpha/beta hydrolase family DLH PF01738.18 ELR13870.1 - 0.044 13.3 0.1 0.14 11.7 0.0 1.9 2 0 0 2 2 2 0 Dienelactone hydrolase family UPF1_Zn_bind PF09416.10 ELR13871.1 - 9.6e-74 246.4 4.6 1.8e-73 245.5 4.6 1.5 1 0 0 1 1 1 1 RNA helicase (UPF2 interacting domain) AAA_12 PF13087.6 ELR13871.1 - 2.6e-61 206.7 0.0 4.1e-61 206.1 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 ELR13871.1 - 5.8e-50 170.5 3.0 4.2e-28 98.9 0.1 2.3 1 1 1 2 2 2 2 AAA domain DUF5599 PF18141.1 ELR13871.1 - 3.8e-32 110.4 0.0 7.1e-32 109.5 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF5599) AAA_30 PF13604.6 ELR13871.1 - 1.1e-14 54.7 0.2 1e-13 51.5 0.2 2.4 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.6 ELR13871.1 - 1.7e-11 44.6 0.0 4.2e-11 43.4 0.0 1.6 1 1 0 1 1 1 1 AAA domain UvrD-helicase PF00580.21 ELR13871.1 - 1.5e-05 24.7 0.1 0.00049 19.7 0.1 2.8 2 1 0 3 3 3 1 UvrD/REP helicase N-terminal domain ResIII PF04851.15 ELR13871.1 - 2.6e-05 24.3 0.0 4.6e-05 23.5 0.0 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_RecD PF05127.14 ELR13871.1 - 0.00013 21.9 0.0 0.00027 20.9 0.0 1.6 1 0 0 1 1 1 1 Helicase DUF2075 PF09848.9 ELR13871.1 - 0.00028 20.2 1.4 0.0039 16.5 0.0 3.0 3 1 0 4 4 4 1 Uncharacterized conserved protein (DUF2075) DEAD PF00270.29 ELR13871.1 - 0.0018 18.0 0.2 0.0035 17.1 0.2 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase PhoH PF02562.16 ELR13871.1 - 0.0031 17.0 0.1 0.0063 16.0 0.1 1.4 1 0 0 1 1 1 1 PhoH-like protein PIF1 PF05970.14 ELR13871.1 - 0.019 14.1 0.1 4.6 6.3 0.0 2.2 2 0 0 2 2 2 0 PIF1-like helicase AAA_22 PF13401.6 ELR13871.1 - 0.032 14.5 0.0 0.096 13.0 0.0 1.8 1 0 0 1 1 1 0 AAA domain SRP54 PF00448.22 ELR13871.1 - 0.034 13.8 0.0 0.062 12.9 0.0 1.4 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain ATPase PF06745.13 ELR13871.1 - 0.052 12.9 0.0 0.15 11.4 0.0 1.7 2 0 0 2 2 2 0 KaiC Ras PF00071.22 ELR13872.1 - 2.8e-29 101.8 0.0 4e-29 101.3 0.0 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR13872.1 - 1.4e-13 51.1 0.0 2.8e-13 50.1 0.0 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase LRR_4 PF12799.7 ELR13872.1 - 2.8e-07 30.8 3.2 0.00076 19.8 1.4 3.1 2 1 1 3 3 3 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 ELR13872.1 - 5.5e-06 26.0 3.2 1.7e-05 24.4 3.2 1.9 1 0 0 1 1 1 1 Leucine rich repeat LRR_9 PF14580.6 ELR13872.1 - 0.0011 18.5 0.1 0.0019 17.8 0.1 1.3 1 0 0 1 1 1 1 Leucine-rich repeat adh_short_C2 PF13561.6 ELR13872.1 - 0.21 11.1 0.1 0.42 10.1 0.1 1.4 1 0 0 1 1 1 0 Enoyl-(Acyl carrier protein) reductase IBR PF01485.21 ELR13873.1 - 1.1e-09 38.3 43.4 8.9e-08 32.3 9.2 4.5 3 1 1 4 4 4 2 IBR domain, a half RING-finger domain zf-RING_5 PF14634.6 ELR13873.1 - 4.8e-08 32.8 7.2 4.8e-08 32.8 7.2 3.6 3 1 0 3 3 3 1 zinc-RING finger domain zf-RING_2 PF13639.6 ELR13873.1 - 1.2e-07 32.0 7.3 1.2e-07 32.0 7.3 3.6 2 1 1 3 3 3 1 Ring finger domain zf-RING_UBOX PF13445.6 ELR13873.1 - 1.2e-07 31.6 4.3 1.2e-07 31.6 4.3 2.4 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4 PF00097.25 ELR13873.1 - 2e-05 24.4 7.2 2e-05 24.4 7.2 3.3 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 ELR13873.1 - 6.4e-05 22.7 9.1 6.4e-05 22.7 9.1 3.8 3 1 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 ELR13873.1 - 0.00084 19.0 6.1 0.0025 17.5 6.1 1.9 1 0 0 1 1 1 1 RING-like zinc finger zinc_ribbon_2 PF13240.6 ELR13873.1 - 0.19 11.5 0.1 0.19 11.5 0.1 4.2 5 0 0 5 5 5 0 zinc-ribbon domain zf-ribbon_3 PF13248.6 ELR13873.1 - 0.46 10.0 8.7 0.33 10.4 0.2 3.8 3 0 0 3 3 3 0 zinc-ribbon domain CBS PF00571.28 ELR13874.1 - 3.2e-31 107.6 0.4 2e-10 41.0 0.2 4.2 4 0 0 4 4 4 4 CBS domain Pkinase_Tyr PF07714.17 ELR13875.1 - 3.8e-115 383.6 0.0 1.6e-56 191.5 0.0 2.4 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 ELR13875.1 - 3.7e-96 321.6 0.0 3.7e-47 160.9 0.0 2.7 3 0 0 3 3 3 2 Protein kinase domain 5_nucleotid_C PF02872.18 ELR13875.1 - 1.2e-26 93.9 0.0 2.1e-26 93.0 0.0 1.4 1 0 0 1 1 1 1 5'-nucleotidase, C-terminal domain Kinase-like PF14531.6 ELR13875.1 - 2.9e-09 36.7 0.0 1.2e-05 24.8 0.0 2.2 2 0 0 2 2 2 2 Kinase-like Pkinase_fungal PF17667.1 ELR13875.1 - 1.7e-06 27.1 0.0 0.0008 18.3 0.0 2.2 2 0 0 2 2 2 2 Fungal protein kinase APH PF01636.23 ELR13875.1 - 2.1e-05 24.6 2.2 0.0049 16.8 0.0 2.8 3 0 0 3 3 3 2 Phosphotransferase enzyme family Kdo PF06293.14 ELR13875.1 - 0.00032 20.1 0.1 0.97 8.7 0.0 2.6 3 0 0 3 3 3 2 Lipopolysaccharide kinase (Kdo/WaaP) family FTA2 PF13095.6 ELR13875.1 - 0.02 14.5 0.0 0.14 11.8 0.0 2.1 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 RIO1 PF01163.22 ELR13875.1 - 0.13 11.9 0.1 2.1 7.9 0.0 2.2 2 0 0 2 2 2 0 RIO1 family EB PF01683.18 ELR13875.1 - 0.35 11.2 9.2 3.8 7.9 2.0 2.7 3 0 0 3 3 3 0 EB module EGF_2 PF07974.13 ELR13875.1 - 0.39 11.1 11.5 0.81 10.1 11.5 1.6 1 0 0 1 1 1 0 EGF-like domain Pkinase_Tyr PF07714.17 ELR13876.1 - 3.6e-120 400.1 0.0 1.6e-59 201.3 0.0 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 ELR13876.1 - 1.6e-106 355.5 0.0 2.7e-55 187.6 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain PBP_like_2 PF12849.7 ELR13876.1 - 3.4e-28 99.1 4.4 1.3e-13 51.3 0.8 2.4 2 0 0 2 2 2 2 PBP superfamily domain Guanylate_cyc PF00211.20 ELR13876.1 - 6.9e-14 51.9 0.0 1.6e-13 50.7 0.0 1.6 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain APH PF01636.23 ELR13876.1 - 2.1e-06 27.9 0.3 0.0015 18.5 0.0 2.5 2 0 0 2 2 2 2 Phosphotransferase enzyme family Kinase-like PF14531.6 ELR13876.1 - 0.00013 21.4 0.0 0.28 10.5 0.0 2.3 2 0 0 2 2 2 2 Kinase-like FTA2 PF13095.6 ELR13876.1 - 0.0014 18.3 0.0 0.23 11.0 0.0 3.0 2 2 2 4 4 4 1 Kinetochore Sim4 complex subunit FTA2 TMEM154 PF15102.6 ELR13876.1 - 0.0028 17.6 0.6 0.0094 15.9 0.0 2.1 2 0 0 2 2 2 1 TMEM154 protein family SBP_bac_1 PF01547.25 ELR13876.1 - 0.0063 16.5 0.1 0.12 12.2 0.0 2.6 2 0 0 2 2 2 1 Bacterial extracellular solute-binding protein Kdo PF06293.14 ELR13876.1 - 0.044 13.1 0.4 9.6 5.5 0.0 2.3 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 ELR13876.1 - 0.048 12.4 0.1 5.3 5.7 0.0 2.8 3 0 0 3 3 3 0 Fungal protein kinase Seadorna_VP7 PF07387.11 ELR13876.1 - 0.19 10.8 0.3 0.66 9.0 0.0 2.0 2 0 0 2 2 2 0 Seadornavirus VP7 Haspin_kinase PF12330.8 ELR13876.1 - 0.22 10.4 0.0 0.22 10.4 0.0 2.8 4 0 0 4 4 3 0 Haspin like kinase domain HATPase_c PF02518.26 ELR13877.1 - 5.5e-24 84.8 0.0 1e-23 84.0 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 ELR13877.1 - 6.6e-17 61.3 0.4 2e-16 59.7 0.1 2.1 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain Response_reg PF00072.24 ELR13877.1 - 2.3e-14 53.5 0.3 6.6e-14 52.0 0.2 1.8 2 0 0 2 2 2 1 Response regulator receiver domain MEDS PF14417.6 ELR13877.1 - 5.9e-12 45.7 0.0 4e-09 36.5 0.0 2.9 2 1 1 3 3 3 2 MEDS: MEthanogen/methylotroph, DcmR Sensory domain HATPase_c_3 PF13589.6 ELR13877.1 - 0.013 15.3 0.0 0.027 14.3 0.0 1.4 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase ATPase PF06745.13 ELR13877.1 - 0.16 11.3 0.0 0.31 10.3 0.0 1.4 1 0 0 1 1 1 0 KaiC ADH_zinc_N_2 PF13602.6 ELR13878.1 - 4.3e-23 82.8 0.0 7.3e-23 82.1 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.26 ELR13878.1 - 5.8e-12 45.7 0.6 1.1e-11 44.9 0.6 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ThiF PF00899.21 ELR13878.1 - 0.85 8.9 3.0 1.2 8.5 1.7 1.7 2 0 0 2 2 2 0 ThiF family Clathrin_lg_ch PF01086.17 ELR13879.1 - 3.1e-27 96.1 5.4 3.8e-27 95.8 5.4 1.1 1 0 0 1 1 1 1 Clathrin light chain ORC6 PF05460.13 ELR13879.1 - 0.085 12.1 7.5 0.096 11.9 7.5 1.0 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) XRN_M PF17846.1 ELR13879.1 - 0.44 9.4 5.2 0.53 9.2 5.2 1.1 1 0 0 1 1 1 0 Xrn1 helical domain VIR_N PF15912.5 ELR13879.1 - 1.1 8.8 12.0 1.5 8.4 12.0 1.1 1 0 0 1 1 1 0 Virilizer, N-terminal Lant_dehydr_C PF14028.6 ELR13879.1 - 1.7 8.1 9.2 2.5 7.6 5.1 2.0 1 1 1 2 2 2 0 Lantibiotic biosynthesis dehydratase C-term V_ATPase_I PF01496.19 ELR13879.1 - 1.9 6.3 4.8 2.1 6.2 4.8 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF4407 PF14362.6 ELR13879.1 - 5.2 6.3 9.9 8.4 5.6 9.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF4337 PF14235.6 ELR13879.1 - 9.3 6.3 8.7 17 5.5 8.7 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) Adenosine_kin PF04008.14 ELR13881.1 - 5.7e-71 237.3 0.0 6.5e-71 237.1 0.0 1.0 1 0 0 1 1 1 1 Adenosine specific kinase Exonuc_V_gamma PF04257.14 ELR13881.1 - 0.22 9.7 0.0 0.25 9.5 0.0 1.1 1 0 0 1 1 1 0 Exodeoxyribonuclease V, gamma subunit Suf PF05843.14 ELR13882.1 - 7e-11 42.7 0.4 6.5e-09 36.2 0.3 3.2 2 1 1 3 3 3 1 Suppressor of forked protein (Suf) TPR_14 PF13428.6 ELR13882.1 - 1.3e-10 41.2 28.4 0.0009 19.9 0.3 8.4 6 3 4 10 10 10 4 Tetratricopeptide repeat NRDE-2 PF08424.10 ELR13882.1 - 2.1e-08 33.7 6.9 1.4e-05 24.4 0.2 3.6 3 1 0 3 3 3 2 NRDE-2, necessary for RNA interference TPR_19 PF14559.6 ELR13882.1 - 2.1e-07 31.4 8.5 0.00038 20.9 0.1 3.7 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_17 PF13431.6 ELR13882.1 - 0.00079 19.6 1.4 7.8 7.1 0.0 4.8 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_6 PF13174.6 ELR13882.1 - 0.012 16.1 6.8 1.5 9.6 0.1 6.1 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_2 PF07719.17 ELR13882.1 - 0.2 11.9 5.0 23 5.4 0.1 4.5 5 0 0 5 5 5 0 Tetratricopeptide repeat HAT PF02184.16 ELR13882.1 - 0.3 11.1 7.2 3.8 7.5 0.4 4.2 4 0 0 4 4 4 0 HAT (Half-A-TPR) repeat ATP-synt_D PF01813.17 ELR13883.1 - 5.1e-69 232.0 3.9 6.2e-69 231.8 3.9 1.1 1 0 0 1 1 1 1 ATP synthase subunit D ABC_tran PF00005.27 ELR13884.1 - 8e-27 94.4 0.0 1.5e-26 93.6 0.0 1.4 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 ELR13884.1 - 0.00064 19.6 0.2 0.0037 17.1 0.0 2.0 2 0 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 ELR13884.1 - 0.0052 16.3 0.1 0.029 13.8 0.1 1.9 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 ELR13884.1 - 0.0066 16.8 0.1 0.015 15.7 0.0 1.7 2 1 0 2 2 2 1 AAA ATPase domain Rad17 PF03215.15 ELR13884.1 - 0.016 15.2 0.0 0.027 14.4 0.0 1.6 1 1 0 1 1 1 0 Rad17 P-loop domain AAA_30 PF13604.6 ELR13884.1 - 0.027 14.2 0.0 0.048 13.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain T6SS_VipA PF05591.12 ELR13884.1 - 0.032 14.1 0.1 0.067 13.0 0.1 1.5 1 0 0 1 1 1 0 Type VI secretion system, VipA, VC_A0107 or Hcp2 DUF2572 PF10833.8 ELR13884.1 - 0.038 13.7 0.2 0.068 12.9 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2572) SbcCD_C PF13558.6 ELR13884.1 - 0.052 13.8 0.2 0.87 9.9 0.2 2.5 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit RuvB_N PF05496.12 ELR13884.1 - 0.061 13.1 0.0 0.094 12.5 0.0 1.4 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain AAA_29 PF13555.6 ELR13884.1 - 0.11 12.3 0.0 0.21 11.4 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain NACHT PF05729.12 ELR13884.1 - 0.11 12.4 1.7 9.5 6.1 0.2 2.2 2 0 0 2 2 2 0 NACHT domain RsgA_GTPase PF03193.16 ELR13884.1 - 0.11 12.4 0.1 0.31 10.9 0.1 1.7 1 1 1 2 2 2 0 RsgA GTPase AAA PF00004.29 ELR13884.1 - 0.15 12.5 0.2 11 6.4 0.1 2.3 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Rhodanese PF00581.20 ELR13885.1 - 0.0094 16.5 0.1 0.026 15.0 0.0 1.7 2 0 0 2 2 2 1 Rhodanese-like domain Lactamase_B_2 PF12706.7 ELR13886.1 - 9.8e-13 48.1 2.5 6.1e-12 45.5 1.4 2.7 2 1 0 2 2 2 1 Beta-lactamase superfamily domain Lactamase_B_4 PF13691.6 ELR13886.1 - 4.3e-12 45.5 0.1 5.6e-11 42.0 0.0 2.3 2 0 0 2 2 2 1 tRNase Z endonuclease DUF4604 PF15377.6 ELR13886.1 - 0.16 12.4 11.0 4.5 7.7 10.3 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4604) TAF4 PF05236.14 ELR13886.1 - 0.56 9.9 7.6 0.92 9.2 7.6 1.3 1 0 0 1 1 1 0 Transcription initiation factor TFIID component TAF4 family HATPase_c PF02518.26 ELR13887.1 - 2.1e-29 102.3 0.1 5.7e-29 100.9 0.1 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 ELR13887.1 - 1.1e-28 99.6 0.1 1.7e-22 79.7 0.0 2.9 2 0 0 2 2 2 2 Response regulator receiver domain HisKA PF00512.25 ELR13887.1 - 1.1e-20 73.5 0.1 7.8e-20 70.7 0.1 2.6 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain HAMP PF00672.25 ELR13887.1 - 3.8e-19 68.8 3.0 9.3e-07 29.1 0.1 3.9 3 0 0 3 3 3 3 HAMP domain APG17 PF04108.12 ELR13887.1 - 0.0018 17.5 0.0 0.84 8.7 0.0 2.3 1 1 1 2 2 2 2 Autophagy protein Apg17 DUF948 PF06103.11 ELR13887.1 - 0.0049 17.1 14.3 2.4 8.5 3.3 4.6 1 1 1 2 2 2 2 Bacterial protein of unknown function (DUF948) PseudoU_synth_1 PF01416.20 ELR13887.1 - 0.0099 16.3 0.7 31 5.1 0.0 3.7 1 1 2 3 3 3 0 tRNA pseudouridine synthase DUF5082 PF16888.5 ELR13887.1 - 0.013 15.8 0.0 1.5 9.1 0.0 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF5082) WXG100 PF06013.12 ELR13887.1 - 0.02 15.1 3.1 4.1 7.7 0.2 3.3 3 0 0 3 3 3 0 Proteins of 100 residues with WXG SpoIIID PF12116.8 ELR13887.1 - 0.024 14.7 0.0 12 6.1 0.0 2.9 2 0 0 2 2 2 0 Stage III sporulation protein D Laminin_II PF06009.12 ELR13887.1 - 0.033 14.2 7.3 0.4 10.7 0.2 3.4 3 0 0 3 3 3 0 Laminin Domain II DUF1843 PF08898.10 ELR13887.1 - 0.051 14.1 0.2 11 6.6 0.1 3.0 2 0 0 2 2 2 0 Domain of unknown function (DUF1843) DUF4172 PF13776.6 ELR13887.1 - 0.068 13.5 0.1 0.94 9.9 0.1 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4172) GatB_Yqey PF02637.18 ELR13887.1 - 0.075 12.9 0.6 12 5.8 0.1 2.7 2 0 0 2 2 2 0 GatB domain ApoLp-III PF07464.11 ELR13887.1 - 0.088 12.9 5.1 1.8 8.6 1.8 2.9 1 1 1 2 2 2 0 Apolipophorin-III precursor (apoLp-III) Baculo_PEP_C PF04513.12 ELR13887.1 - 1.5 8.8 16.9 22 5.1 8.7 3.6 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus HAMP PF00672.25 ELR13888.1 - 1e-98 323.6 42.7 2.2e-07 31.1 0.1 15.0 13 2 0 13 13 13 12 HAMP domain APG17 PF04108.12 ELR13888.1 - 8.9e-22 77.7 0.0 0.044 12.9 0.1 8.8 1 1 7 8 8 8 7 Autophagy protein Apg17 DUF948 PF06103.11 ELR13888.1 - 9.4e-18 64.3 116.3 0.06 13.6 1.8 18.9 1 1 11 13 13 13 10 Bacterial protein of unknown function (DUF948) WXG100 PF06013.12 ELR13888.1 - 7.8e-15 54.9 49.0 2.3 8.5 0.1 13.2 12 1 1 13 13 12 10 Proteins of 100 residues with WXG SpoIIID PF12116.8 ELR13888.1 - 2.3e-12 46.8 6.1 30 4.8 0.0 11.7 11 0 0 11 11 11 0 Stage III sporulation protein D DUF3829 PF12889.7 ELR13888.1 - 3.2e-11 43.2 27.0 3.6 7.0 0.3 11.1 7 3 1 11 11 11 3 Protein of unknown function (DUF3829) DUF1843 PF08898.10 ELR13888.1 - 4.6e-11 43.0 29.1 14 6.3 0.1 12.8 13 0 0 13 13 13 0 Domain of unknown function (DUF1843) HTH_6 PF01418.17 ELR13888.1 - 3.2e-10 39.9 0.2 27 4.9 0.0 9.7 11 0 0 11 11 11 0 Helix-turn-helix domain, rpiR family GatB_Yqey PF02637.18 ELR13888.1 - 5.1e-10 39.4 36.6 2.6 7.9 0.4 11.8 11 1 1 12 12 12 2 GatB domain PseudoU_synth_1 PF01416.20 ELR13888.1 - 9.3e-10 38.9 19.1 2.8 8.5 0.0 11.5 5 3 1 10 10 10 1 tRNA pseudouridine synthase GLE1 PF07817.13 ELR13888.1 - 7.2e-09 35.2 26.0 1.3 8.2 0.2 10.9 4 4 7 11 11 11 3 GLE1-like protein ApoLp-III PF07464.11 ELR13888.1 - 3.7e-07 30.3 61.1 1.3 9.1 1.8 12.2 1 1 11 12 12 12 8 Apolipophorin-III precursor (apoLp-III) NYD-SP28 PF14772.6 ELR13888.1 - 6.7e-06 26.1 16.9 84 3.3 0.0 11.0 12 0 0 12 12 12 0 Sperm tail DUF1759 PF03564.15 ELR13888.1 - 1.1e-05 25.3 19.7 12 5.8 0.0 10.8 11 1 1 12 12 12 0 Protein of unknown function (DUF1759) Fib_alpha PF08702.10 ELR13888.1 - 2.1e-05 24.7 31.5 0.56 10.4 0.7 10.7 10 1 0 11 11 11 1 Fibrinogen alpha/beta chain family NAAA-beta PF15508.6 ELR13888.1 - 7.8e-05 22.9 9.4 29 5.1 0.0 9.7 12 0 0 12 12 11 0 beta subunit of N-acylethanolamine-hydrolyzing acid amidase Phage_lysis PF03245.13 ELR13888.1 - 0.0045 17.1 38.1 5.2 7.2 0.2 11.0 11 1 1 12 12 12 1 Bacteriophage Rz lysis protein CENP-F_leu_zip PF10473.9 ELR13888.1 - 0.0047 16.9 32.1 48 4.0 0.1 11.7 12 0 0 12 12 12 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 TcpS PF17456.2 ELR13888.1 - 0.0049 16.9 21.7 2.1 8.4 0.1 9.1 10 1 1 11 11 11 1 Toxin-coregulated pilus protein S MCPsignal PF00015.21 ELR13888.1 - 0.0055 16.5 85.2 0.9 9.3 0.8 12.0 2 1 10 13 13 13 8 Methyl-accepting chemotaxis protein (MCP) signalling domain tRNA_bind_2 PF13725.6 ELR13888.1 - 0.0066 16.2 3.1 18 5.0 0.0 4.4 4 0 0 4 4 4 0 Possible tRNA binding domain Peptidase_M75 PF09375.10 ELR13888.1 - 0.054 13.0 54.6 0.09 12.2 2.6 7.9 1 1 6 8 8 8 0 Imelysin SEO_N PF14576.6 ELR13888.1 - 1.9 7.6 14.2 20 4.2 0.0 7.6 10 3 1 11 11 11 0 Sieve element occlusion N-terminus Golgin_A5 PF09787.9 ELR13889.1 - 6.9e-50 170.3 30.4 6.9e-50 170.3 30.4 3.0 1 1 2 3 3 3 1 Golgin subfamily A member 5 Tropomyosin PF00261.20 ELR13889.1 - 0.0007 19.0 17.9 0.0007 19.0 17.9 4.2 2 2 2 4 4 4 2 Tropomyosin CASP_C PF08172.12 ELR13889.1 - 0.0028 17.0 1.2 0.0028 17.0 1.2 6.1 3 2 2 5 5 5 2 CASP C terminal Spc7 PF08317.11 ELR13889.1 - 0.098 11.5 80.1 0.013 14.5 20.2 4.1 1 1 3 4 4 4 0 Spc7 kinetochore protein Cast PF10174.9 ELR13889.1 - 0.45 8.7 69.8 2.1 6.5 60.7 2.9 1 1 1 2 2 2 0 RIM-binding protein of the cytomatrix active zone Fez1 PF06818.15 ELR13889.1 - 0.73 10.3 74.6 2.5 8.5 31.4 3.8 1 1 3 4 4 4 0 Fez1 DUF4407 PF14362.6 ELR13889.1 - 2.5 7.4 63.1 4 6.7 23.3 3.6 1 1 2 3 3 3 0 Domain of unknown function (DUF4407) BRCT PF00533.26 ELR13890.1 - 1e-08 35.4 0.0 2.6e-08 34.1 0.0 1.7 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 ELR13890.1 - 3.6e-06 27.3 0.0 1.1e-05 25.8 0.0 1.8 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain RRM_1 PF00076.22 ELR13890.1 - 4.5e-05 23.2 0.0 0.0002 21.1 0.0 2.1 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PTCB-BRCT PF12738.7 ELR13890.1 - 0.00015 21.6 0.1 0.0004 20.3 0.1 1.7 1 0 0 1 1 1 1 twin BRCT domain Nup35_RRM_2 PF14605.6 ELR13890.1 - 0.05 13.6 0.0 0.092 12.8 0.0 1.4 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif Tom5 PF10642.9 ELR13890.1 - 0.13 12.3 2.7 0.67 10.0 2.7 2.3 1 0 0 1 1 1 0 Mitochondrial import receptor subunit or translocase F-box-like PF12937.7 ELR13891.1 - 2.2e-06 27.5 0.0 4.8e-06 26.4 0.0 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ELR13891.1 - 0.012 15.5 0.0 0.046 13.6 0.0 2.0 2 0 0 2 2 2 0 F-box domain zf-CCHH PF10283.9 ELR13893.1 - 3.2e-15 55.8 6.6 5.6e-15 55.0 6.6 1.4 1 0 0 1 1 1 1 PBZ domain PARP PF00644.20 ELR13893.1 - 1.1e-14 54.5 8.2 1.5e-08 34.5 0.0 4.0 2 1 3 5 5 5 3 Poly(ADP-ribose) polymerase catalytic domain ENT PF03735.14 ELR13893.1 - 0.00075 19.5 0.0 0.0016 18.5 0.0 1.5 1 0 0 1 1 1 1 ENT domain DEC-1_N PF04625.13 ELR13893.1 - 0.22 10.5 6.7 0.36 9.8 6.7 1.3 1 0 0 1 1 1 0 DEC-1 protein, N-terminal region MSA-2c PF12238.8 ELR13893.1 - 3.5 7.6 15.0 7.1 6.6 15.0 1.5 1 0 0 1 1 1 0 Merozoite surface antigen 2c DUF908 PF06012.12 ELR13893.1 - 6.3 6.1 6.8 0.54 9.6 2.0 1.6 2 0 0 2 2 2 0 Domain of Unknown Function (DUF908) Dioxygenase_C PF00775.21 ELR13895.1 - 0.024 14.1 0.0 0.057 12.8 0.0 1.6 1 1 0 1 1 1 0 Dioxygenase PSII_BNR PF14870.6 ELR13895.1 - 0.064 12.5 0.0 0.12 11.7 0.0 1.4 1 0 0 1 1 1 0 Photosynthesis system II assembly factor YCF48 DUF1586 PF07625.11 ELR13895.1 - 0.51 10.5 0.1 0.51 10.5 0.1 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF1586) RicinB_lectin_2 PF14200.6 ELR13896.1 - 0.0037 18.0 2.2 0.026 15.2 0.6 2.7 1 1 2 3 3 3 3 Ricin-type beta-trefoil lectin domain-like SlyX PF04102.12 ELR13897.1 - 6.4e-05 23.5 27.4 0.008 16.8 5.9 5.7 5 2 0 5 5 5 2 SlyX Fmp27_WPPW PF10359.9 ELR13897.1 - 9.3e-05 21.5 9.1 9.3e-05 21.5 9.1 2.5 1 1 0 2 2 2 1 RNA pol II promoter Fmp27 protein domain YabA PF06156.13 ELR13897.1 - 0.0013 19.3 4.0 0.0013 19.3 4.0 4.1 3 1 0 3 3 3 1 Initiation control protein YabA DUF724 PF05266.14 ELR13897.1 - 0.016 15.0 8.7 0.016 15.0 8.7 3.4 3 1 1 4 4 4 0 Protein of unknown function (DUF724) KfrA_N PF11740.8 ELR13897.1 - 0.094 13.4 12.5 0.15 12.8 2.9 2.9 2 0 0 2 2 2 0 Plasmid replication region DNA-binding N-term PspA_IM30 PF04012.12 ELR13897.1 - 0.097 12.2 34.5 0.031 13.9 7.9 3.0 3 0 0 3 3 3 0 PspA/IM30 family Surfac_D-trimer PF09006.11 ELR13897.1 - 0.12 12.2 0.4 1.8 8.5 0.0 2.5 2 0 0 2 2 2 0 Lung surfactant protein D coiled-coil trimerisation CENP-F_leu_zip PF10473.9 ELR13897.1 - 0.13 12.3 38.7 0.29 11.2 9.8 3.1 3 0 0 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF3450 PF11932.8 ELR13897.1 - 0.26 10.6 30.8 0.54 9.5 4.9 3.8 3 1 1 4 4 4 0 Protein of unknown function (DUF3450) FUSC PF04632.12 ELR13897.1 - 0.32 9.5 3.9 5.1 5.5 0.1 2.0 1 1 0 2 2 2 0 Fusaric acid resistance protein family Laminin_II PF06009.12 ELR13897.1 - 0.4 10.7 20.6 0.44 10.6 2.8 3.1 1 1 2 3 3 3 0 Laminin Domain II Troponin PF00992.20 ELR13897.1 - 0.94 9.8 37.0 0.28 11.5 5.4 3.0 3 0 0 3 3 3 0 Troponin Fez1 PF06818.15 ELR13897.1 - 0.96 9.9 45.9 0.51 10.7 13.8 2.8 2 1 1 3 3 3 0 Fez1 EzrA PF06160.12 ELR13897.1 - 0.97 7.5 39.3 0.021 13.0 6.8 2.9 3 1 0 3 3 3 0 Septation ring formation regulator, EzrA DUF4201 PF13870.6 ELR13897.1 - 0.97 9.1 38.4 0.7 9.6 19.2 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4201) Rootletin PF15035.6 ELR13897.1 - 1.2 9.1 31.0 0.64 10.0 3.2 2.9 1 1 2 3 3 3 0 Ciliary rootlet component, centrosome cohesion Tropomyosin_1 PF12718.7 ELR13897.1 - 1.6 8.9 47.5 0.03 14.5 7.6 4.0 3 1 0 3 3 3 0 Tropomyosin like ERM PF00769.19 ELR13897.1 - 1.8 8.3 56.1 2.1 8.1 16.5 3.1 2 1 0 3 3 3 0 Ezrin/radixin/moesin family MAD PF05557.13 ELR13897.1 - 2.5 6.4 41.0 0.19 10.1 10.4 2.5 1 1 1 2 2 2 0 Mitotic checkpoint protein Exonuc_VII_L PF02601.15 ELR13897.1 - 4 6.9 24.9 2.5 7.6 2.2 2.2 1 1 1 2 2 2 0 Exonuclease VII, large subunit DUF4515 PF14988.6 ELR13897.1 - 4.8 7.0 41.7 1.2 8.9 5.2 3.9 3 1 1 4 4 4 0 Domain of unknown function (DUF4515) Tmemb_cc2 PF10267.9 ELR13897.1 - 4.9 6.2 39.8 8.8 5.3 2.8 3.3 2 1 0 2 2 2 0 Predicted transmembrane and coiled-coil 2 protein Nup54 PF13874.6 ELR13897.1 - 6.8 6.8 29.6 0.23 11.6 7.3 4.0 2 1 1 4 4 4 0 Nucleoporin complex subunit 54 LOH1CR12 PF10158.9 ELR13897.1 - 8.7 6.4 8.4 3.2 7.8 2.0 2.6 2 1 0 2 2 2 0 Tumour suppressor protein Cyclin_C_2 PF16899.5 ELR13898.1 - 1.6e-16 60.6 0.8 7.1e-15 55.3 0.0 2.8 2 2 0 2 2 2 1 Cyclin C-terminal domain Cyclin_N PF00134.23 ELR13898.1 - 3.4e-10 39.8 0.0 7.2e-10 38.7 0.0 1.5 1 0 0 1 1 1 1 Cyclin, N-terminal domain XRN_M PF17846.1 ELR13898.1 - 0.16 10.9 4.6 0.25 10.2 4.6 1.3 1 0 0 1 1 1 0 Xrn1 helical domain U1snRNP70_N PF12220.8 ELR13898.1 - 0.31 11.7 6.5 0.16 12.7 0.5 2.7 2 0 0 2 2 2 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal Peptidase_S49_N PF08496.10 ELR13898.1 - 1.3 9.1 4.2 3.6 7.6 1.9 2.5 2 1 0 2 2 2 0 Peptidase family S49 N-terminal RNase_PH PF01138.21 ELR13899.1 - 2.4e-21 76.6 2.0 5.3e-21 75.5 0.0 2.3 2 1 0 2 2 2 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 ELR13899.1 - 5.2e-09 36.0 0.0 1.5e-08 34.5 0.0 1.8 1 0 0 1 1 1 1 3' exoribonuclease family, domain 2 CENP-N PF05238.13 ELR13899.1 - 0.017 14.5 7.7 0.024 14.0 7.7 1.2 1 0 0 1 1 1 0 Kinetochore protein CHL4 like CDC45 PF02724.14 ELR13899.1 - 0.018 13.4 11.0 0.023 13.0 11.0 1.1 1 0 0 1 1 1 0 CDC45-like protein CDC27 PF09507.10 ELR13899.1 - 0.88 8.9 33.6 1.3 8.3 33.6 1.3 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 DTW PF03942.15 ELR13901.1 - 6.7e-33 114.1 0.0 9.6e-33 113.6 0.0 1.2 1 0 0 1 1 1 1 DTW domain zf-B_box PF00643.24 ELR13901.1 - 0.29 11.3 1.8 0.52 10.5 1.8 1.4 1 0 0 1 1 1 0 B-box zinc finger DNA_pol_A_exo1 PF01612.20 ELR13902.1 - 2.7e-27 95.6 0.0 6.4e-27 94.4 0.0 1.7 1 0 0 1 1 1 1 3'-5' exonuclease AAA_16 PF13191.6 ELR13902.1 - 1.2e-06 29.0 2.0 3.3e-05 24.4 0.0 3.2 3 0 0 3 3 3 1 AAA ATPase domain AAA PF00004.29 ELR13902.1 - 1.5e-06 28.7 0.0 3.6e-06 27.4 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) NTPase_1 PF03266.15 ELR13902.1 - 0.00021 21.3 0.0 0.14 12.0 0.0 2.5 2 0 0 2 2 2 1 NTPase AAA_5 PF07728.14 ELR13902.1 - 0.00023 21.2 0.1 0.0012 18.8 0.0 2.3 3 0 0 3 3 2 1 AAA domain (dynein-related subfamily) AAA_24 PF13479.6 ELR13902.1 - 0.00039 20.2 0.0 0.0021 17.8 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_28 PF13521.6 ELR13902.1 - 0.00052 20.3 0.0 0.0024 18.1 0.0 2.2 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.6 ELR13902.1 - 0.00062 20.3 0.0 0.0055 17.3 0.0 2.4 2 0 0 2 2 2 1 AAA domain T2SSE PF00437.20 ELR13902.1 - 0.0007 18.7 1.0 0.0013 17.8 1.0 1.4 1 0 0 1 1 1 1 Type II/IV secretion system protein Viral_helicase1 PF01443.18 ELR13902.1 - 0.0037 17.0 0.0 0.0069 16.2 0.0 1.4 1 0 0 1 1 1 1 Viral (Superfamily 1) RNA helicase Ribosomal_60s PF00428.19 ELR13902.1 - 0.0043 17.6 17.9 2.2 8.9 1.9 4.2 4 0 0 4 4 4 3 60s Acidic ribosomal protein AAA_22 PF13401.6 ELR13902.1 - 0.006 16.9 0.0 0.027 14.8 0.0 2.1 1 1 0 1 1 1 1 AAA domain AAA_25 PF13481.6 ELR13902.1 - 0.0085 15.7 1.9 0.58 9.7 0.0 3.7 4 0 0 4 4 4 1 AAA domain AAA_19 PF13245.6 ELR13902.1 - 0.0088 16.4 0.0 0.047 14.0 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.6 ELR13902.1 - 0.011 15.9 0.0 0.033 14.3 0.0 1.9 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.6 ELR13902.1 - 0.013 15.2 0.3 0.013 15.2 0.3 2.2 2 0 0 2 2 2 0 AAA domain RuvB_N PF05496.12 ELR13902.1 - 0.017 14.8 0.1 0.18 11.6 0.0 2.3 2 0 0 2 2 2 0 Holliday junction DNA helicase RuvB P-loop domain AAA_7 PF12775.7 ELR13902.1 - 0.022 14.3 0.0 0.047 13.2 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_11 PF13086.6 ELR13902.1 - 0.028 14.2 0.2 0.31 10.8 0.0 2.1 1 1 1 2 2 2 0 AAA domain Zeta_toxin PF06414.12 ELR13902.1 - 0.039 13.2 0.0 0.13 11.6 0.0 1.8 2 0 0 2 2 2 0 Zeta toxin DUF815 PF05673.13 ELR13902.1 - 0.049 12.8 0.0 0.088 11.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) TrwB_AAD_bind PF10412.9 ELR13902.1 - 0.055 12.4 0.0 0.18 10.7 0.0 1.8 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain UBM PF14377.6 ELR13902.1 - 0.059 12.8 0.2 0.15 11.6 0.2 1.6 1 0 0 1 1 1 0 Ubiquitin binding region SRP54 PF00448.22 ELR13902.1 - 0.065 12.8 0.1 0.38 10.3 0.1 2.1 1 1 0 1 1 1 0 SRP54-type protein, GTPase domain TniB PF05621.11 ELR13902.1 - 0.076 12.4 0.0 3.3 7.1 0.0 2.4 2 0 0 2 2 2 0 Bacterial TniB protein IstB_IS21 PF01695.17 ELR13902.1 - 0.095 12.4 0.0 7.3 6.3 0.0 2.3 2 0 0 2 2 2 0 IstB-like ATP binding protein NACHT PF05729.12 ELR13902.1 - 0.12 12.2 0.0 0.41 10.5 0.0 2.0 1 0 0 1 1 1 0 NACHT domain Sigma54_activat PF00158.26 ELR13902.1 - 0.17 11.6 0.0 0.54 9.9 0.0 1.8 2 0 0 2 2 2 0 Sigma-54 interaction domain TsaE PF02367.17 ELR13902.1 - 0.18 11.8 0.0 0.37 10.8 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE KdpD PF02702.17 ELR13902.1 - 0.22 11.0 0.1 0.22 11.0 0.1 2.1 2 0 0 2 2 1 0 Osmosensitive K+ channel His kinase sensor domain RNA_helicase PF00910.22 ELR13902.1 - 0.22 11.9 0.0 0.68 10.4 0.0 1.9 1 1 0 1 1 1 0 RNA helicase BTB_2 PF02214.22 ELR13903.1 - 2.5e-18 66.2 0.0 5.6e-18 65.1 0.0 1.6 1 0 0 1 1 1 1 BTB/POZ domain BTB_3 PF16017.5 ELR13903.1 - 7.8e-05 22.7 0.0 0.00017 21.7 0.0 1.6 1 1 1 2 2 2 1 BTB/POZ domain Atg14 PF10186.9 ELR13903.1 - 0.0019 17.3 0.4 0.0021 17.2 0.4 1.1 1 0 0 1 1 1 1 Vacuolar sorting 38 and autophagy-related subunit 14 DUF4795 PF16043.5 ELR13903.1 - 0.047 13.3 1.8 0.065 12.8 1.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4795) IFT57 PF10498.9 ELR13903.1 - 0.061 12.3 0.6 0.088 11.8 0.6 1.1 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 ZapB PF06005.12 ELR13903.1 - 0.092 13.2 3.6 0.23 11.9 3.6 1.7 1 0 0 1 1 1 0 Cell division protein ZapB PEP-utilisers_N PF05524.13 ELR13903.1 - 0.1 12.8 1.4 0.17 12.1 1.4 1.3 1 0 0 1 1 1 0 PEP-utilising enzyme, N-terminal OmpH PF03938.14 ELR13903.1 - 0.14 12.5 4.2 0.21 11.9 4.2 1.2 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) XLF PF09302.11 ELR13903.1 - 0.14 12.3 1.2 0.27 11.4 1.2 1.4 1 0 0 1 1 1 0 XLF-Cernunnos, XRcc4-like factor, NHEJ component APG6_N PF17675.1 ELR13903.1 - 0.31 11.6 6.6 0.5 10.9 6.6 1.3 1 0 0 1 1 1 0 Apg6 coiled-coil region Flavin_Reduct PF01613.18 ELR13904.1 - 4.1e-20 72.4 0.0 6e-20 71.9 0.0 1.1 1 0 0 1 1 1 1 Flavin reductase like domain Aldedh PF00171.22 ELR13905.1 - 1.6e-121 406.1 0.3 1.9e-121 405.8 0.3 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family TFCD_C PF12612.8 ELR13906.1 - 3.1e-43 147.8 0.3 4.9e-42 143.9 0.0 3.2 3 1 0 3 3 3 1 Tubulin folding cofactor D C terminal HEAT_2 PF13646.6 ELR13906.1 - 4.1e-08 33.5 20.0 0.019 15.3 0.1 7.2 6 1 1 7 7 7 4 HEAT repeats HEAT PF02985.22 ELR13906.1 - 8.4e-05 22.5 19.1 0.22 11.9 0.0 9.2 10 1 1 11 11 11 1 HEAT repeat DSHCT PF08148.12 ELR13906.1 - 0.011 15.4 0.1 0.029 14.0 0.1 1.7 1 0 0 1 1 1 0 DSHCT (NUC185) domain T2SSF PF00482.23 ELR13906.1 - 0.012 15.6 0.2 0.038 13.9 0.2 1.9 1 0 0 1 1 1 0 Type II secretion system (T2SS), protein F Cnd1 PF12717.7 ELR13906.1 - 0.015 15.3 0.0 1.4 9.0 0.1 3.3 3 0 0 3 3 3 0 non-SMC mitotic condensation complex subunit 1 HEAT_PBS PF03130.16 ELR13906.1 - 0.077 13.7 5.0 1.7 9.5 0.1 5.0 4 0 0 4 4 4 0 PBS lyase HEAT-like repeat HEAT_EZ PF13513.6 ELR13906.1 - 0.099 13.2 24.9 0.42 11.2 0.0 8.1 8 1 1 9 9 9 0 HEAT-like repeat MMS19_C PF12460.8 ELR13906.1 - 0.11 11.6 0.3 5.1 6.1 0.0 3.7 5 0 0 5 5 5 0 RNAPII transcription regulator C-terminal B56 PF01603.20 ELR13906.1 - 0.2 10.6 0.0 0.51 9.3 0.0 1.6 2 0 0 2 2 2 0 Protein phosphatase 2A regulatory B subunit (B56 family) Sulfotransfer_3 PF13469.6 ELR13907.1 - 9.2e-11 42.5 0.0 2.2e-10 41.3 0.0 1.6 1 1 0 1 1 1 1 Sulfotransferase family Sulfotransfer_1 PF00685.27 ELR13907.1 - 3.8e-07 29.9 0.0 1.7e-05 24.5 0.0 2.9 1 1 0 1 1 1 1 Sulfotransferase domain Costars PF14705.6 ELR13908.1 - 7.4e-18 64.5 0.0 9.1e-18 64.2 0.0 1.0 1 0 0 1 1 1 1 Costars VWA PF00092.28 ELR13909.1 - 9.9e-15 55.2 0.0 2.3e-14 54.1 0.0 1.5 1 1 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.6 ELR13909.1 - 2.8e-10 40.8 0.0 2.3e-09 37.9 0.0 2.2 2 0 0 2 2 2 1 von Willebrand factor type A domain VWA_CoxE PF05762.14 ELR13909.1 - 5e-07 29.3 0.6 3.6e-06 26.5 0.0 2.1 2 0 0 2 2 2 1 VWA domain containing CoxE-like protein VWA_3 PF13768.6 ELR13909.1 - 5.2e-05 23.2 0.0 0.00012 22.0 0.0 1.6 1 0 0 1 1 1 1 von Willebrand factor type A domain GST_C_3 PF14497.6 ELR13910.1 - 9.1e-17 61.1 0.0 1.5e-16 60.4 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 ELR13910.1 - 1.3e-09 38.1 0.0 2.4e-09 37.3 0.0 1.4 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 ELR13910.1 - 4.2e-08 33.4 0.0 8.9e-08 32.4 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 ELR13910.1 - 1.8e-05 24.6 0.1 8.6e-05 22.5 0.1 2.3 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 ELR13910.1 - 0.00038 20.8 0.0 0.00082 19.7 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain Tom37 PF10568.9 ELR13910.1 - 0.018 15.3 0.0 0.1 12.9 0.0 1.9 2 0 0 2 2 2 0 Outer mitochondrial membrane transport complex protein EamA PF00892.20 ELR13911.1 - 1.9e-08 34.5 3.7 1.9e-08 34.5 3.7 3.3 3 0 0 3 3 3 1 EamA-like transporter family SLC35F PF06027.12 ELR13911.1 - 4.7e-05 23.0 4.5 4.7e-05 23.0 4.5 2.7 3 0 0 3 3 3 1 Solute carrier family 35 PUNUT PF16913.5 ELR13911.1 - 0.00025 20.4 1.9 0.00025 20.4 1.9 2.1 2 0 0 2 2 2 1 Purine nucleobase transmembrane transport TPT PF03151.16 ELR13911.1 - 0.00076 18.9 3.3 0.00076 18.9 3.3 3.1 2 1 1 3 3 3 1 Triose-phosphate Transporter family Nuc_sug_transp PF04142.15 ELR13911.1 - 0.0037 16.5 1.6 0.0063 15.7 1.6 1.3 1 0 0 1 1 1 1 Nucleotide-sugar transporter PBP1_TM PF14812.6 ELR13911.1 - 0.051 13.9 0.1 0.051 13.9 0.1 2.6 2 1 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Ycf70 PF17382.2 ELR13911.1 - 0.07 13.5 0.0 0.07 13.5 0.0 3.7 4 1 0 4 4 4 0 Uncharacterized Ycf70-like YfhO PF09586.10 ELR13911.1 - 0.072 11.3 1.4 0.14 10.4 1.4 1.4 1 0 0 1 1 1 0 Bacterial membrane protein YfhO Ribosomal_L27e PF01777.18 ELR13912.1 - 2.2e-32 111.2 6.5 2.9e-32 110.9 6.5 1.1 1 0 0 1 1 1 1 Ribosomal L27e protein family KOW PF00467.29 ELR13912.1 - 9e-06 25.5 0.2 2.4e-05 24.1 0.2 1.7 1 0 0 1 1 1 1 KOW motif Glyco_hydro_5_C PF18564.1 ELR13913.1 - 2.3e-13 50.5 0.0 5e-13 49.4 0.0 1.6 1 0 0 1 1 1 1 Glycoside hydrolase family 5 C-terminal domain Cellulase PF00150.18 ELR13913.1 - 4.7e-09 36.1 0.0 1.9e-08 34.1 0.0 1.7 1 1 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) Glyco_hydro_35 PF01301.19 ELR13913.1 - 0.00067 19.4 0.0 0.001 18.8 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 35 Glyco_hydro_42 PF02449.15 ELR13913.1 - 0.00091 18.7 0.0 0.0068 15.8 0.0 1.9 2 0 0 2 2 2 1 Beta-galactosidase Ribosomal_S13_N PF08069.12 ELR13913.1 - 0.041 13.9 0.1 0.093 12.8 0.1 1.6 1 0 0 1 1 1 0 Ribosomal S13/S15 N-terminal domain INTS5_C PF14838.6 ELR13914.1 - 2.3e-33 115.8 0.4 4.7e-22 78.4 0.1 3.2 3 0 0 3 3 3 3 Integrator complex subunit 5 C-terminus INTS5_N PF14837.6 ELR13914.1 - 1.4e-06 28.1 0.0 6e-06 26.0 0.0 2.0 2 0 0 2 2 2 1 Integrator complex subunit 5 N-terminus Utp13 PF08625.11 ELR13914.1 - 0.0091 15.9 1.2 0.95 9.4 0.1 2.5 2 0 0 2 2 2 2 Utp13 specific WD40 associated domain Ank_4 PF13637.6 ELR13914.1 - 0.037 14.6 0.0 0.13 12.9 0.0 2.0 1 0 0 1 1 1 0 Ankyrin repeats (many copies) Ribosomal_S30 PF04758.14 ELR13915.1 - 1.1e-27 95.9 8.3 1.5e-27 95.5 8.3 1.2 1 0 0 1 1 1 1 Ribosomal protein S30 DUF2407_C PF13373.6 ELR13916.1 - 5.5e-19 68.7 0.5 2.7e-18 66.5 0.5 1.9 1 1 0 1 1 1 1 DUF2407 C-terminal domain SR-25 PF10500.9 ELR13916.1 - 0.56 9.8 11.7 0.88 9.1 11.7 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein AF-4 PF05110.13 ELR13916.1 - 1.5 6.8 6.9 1.8 6.5 6.9 1.0 1 0 0 1 1 1 0 AF-4 proto-oncoprotein Acetyltransf_1 PF00583.25 ELR13918.1 - 4.5e-13 49.5 0.0 5.1e-13 49.3 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 ELR13918.1 - 5.3e-10 39.3 0.0 6.2e-10 39.1 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 ELR13918.1 - 3.9e-08 33.6 0.0 5e-08 33.3 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 ELR13918.1 - 4.6e-07 29.7 0.0 5.5e-07 29.5 0.0 1.2 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_3 PF13302.7 ELR13918.1 - 0.0004 21.1 0.1 0.00049 20.8 0.1 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 ELR13918.1 - 0.0035 17.4 0.0 0.0042 17.2 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 ELR13918.1 - 0.045 13.9 0.1 0.11 12.6 0.0 1.6 1 1 1 2 2 2 0 GCN5-related N-acetyl-transferase Acetyltransf_6 PF13480.7 ELR13918.1 - 0.12 12.5 0.0 0.21 11.8 0.0 1.4 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.6 ELR13918.1 - 0.16 11.6 0.0 0.24 11.1 0.0 1.4 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain DUF1524 PF07510.11 ELR13920.1 - 0.0022 17.8 1.4 0.0025 17.7 0.1 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF1524) TFB6 PF17110.5 ELR13920.1 - 0.14 11.9 2.2 0.17 11.6 2.2 1.1 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH DUF2229 PF09989.9 ELR13920.1 - 0.48 10.0 2.3 0.59 9.7 2.3 1.2 1 0 0 1 1 1 0 CoA enzyme activase uncharacterised domain (DUF2229) DUF724 PF05266.14 ELR13920.1 - 0.73 9.6 7.8 1 9.1 7.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF724) DUF333 PF03891.15 ELR13921.1 - 2.6e-16 59.6 14.0 0.00056 20.1 0.0 6.6 7 0 0 7 7 7 4 Domain of unknown function (DUF333) ETC_C1_NDUFA4 PF04800.12 ELR13921.1 - 0.094 13.0 0.4 23 5.3 0.1 2.6 2 0 0 2 2 2 0 ETC complex I subunit conserved region Pkinase PF00069.25 ELR13922.1 - 1.4e-43 149.2 0.0 1.9e-43 148.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR13922.1 - 1.5e-26 93.2 0.0 2e-26 92.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 ELR13922.1 - 0.00057 18.9 0.0 0.00083 18.4 0.0 1.1 1 0 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 ELR13922.1 - 0.00068 19.0 0.0 0.039 13.3 0.0 2.2 2 0 0 2 2 2 2 Kinase-like APH PF01636.23 ELR13922.1 - 0.001 19.0 0.0 0.003 17.5 0.0 1.7 1 1 1 2 2 2 1 Phosphotransferase enzyme family WD40 PF00400.32 ELR13923.1 - 2.5e-30 104.0 7.8 4.8e-08 33.5 0.2 7.1 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ELR13923.1 - 7.2e-11 42.3 0.1 0.25 11.7 0.0 4.5 2 1 2 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 ELR13923.1 - 0.0023 17.8 0.1 0.55 10.1 0.0 2.6 2 1 0 2 2 2 2 Eukaryotic translation initiation factor eIF2A Na_trans_assoc PF06512.13 ELR13923.1 - 0.04 14.2 12.8 0.066 13.5 12.8 1.3 1 0 0 1 1 1 0 Sodium ion transport-associated Kelch_3 PF13415.6 ELR13924.1 - 1.4e-43 146.4 4.1 1.3e-10 41.3 0.1 6.1 6 0 0 6 6 6 5 Galactose oxidase, central domain Kelch_4 PF13418.6 ELR13924.1 - 4.2e-43 145.1 3.7 7e-10 38.8 0.0 6.1 6 0 0 6 6 6 6 Galactose oxidase, central domain Kelch_6 PF13964.6 ELR13924.1 - 7.3e-36 121.3 1.6 3.6e-06 27.1 0.0 6.2 2 1 4 6 6 6 6 Kelch motif Kelch_5 PF13854.6 ELR13924.1 - 1.1e-32 111.5 0.2 5.7e-07 29.4 0.1 6.0 6 0 0 6 6 6 5 Kelch motif Kelch_1 PF01344.25 ELR13924.1 - 4.3e-26 90.2 3.2 3.6e-05 23.2 0.0 6.6 6 0 0 6 6 6 5 Kelch motif Kelch_2 PF07646.15 ELR13924.1 - 2.6e-24 84.2 5.9 7.9e-05 22.5 0.0 6.3 6 0 0 6 6 6 5 Kelch motif PBP1_TM PF14812.6 ELR13924.1 - 3.5 8.1 8.1 8.1 6.9 8.1 1.5 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Glyco_transf_10 PF00852.19 ELR13925.1 - 9.9e-38 129.6 0.0 1.6e-37 128.9 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Glyco_tran_10_N PF17039.5 ELR13925.1 - 2.9e-12 47.0 0.8 5e-12 46.3 0.2 1.7 2 0 0 2 2 2 1 Fucosyltransferase, N-terminal Not3 PF04065.15 ELR13926.1 - 0.1 12.0 0.5 0.15 11.4 0.5 1.1 1 0 0 1 1 1 0 Not1 N-terminal domain, CCR4-Not complex component DUF4482 PF14818.6 ELR13926.1 - 0.17 12.8 0.2 0.17 12.8 0.2 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4482) GCN5L1 PF06320.13 ELR13926.1 - 0.95 9.6 4.0 1.8 8.7 4.0 1.4 1 0 0 1 1 1 0 GCN5-like protein 1 (GCN5L1) EAP30 PF04157.16 ELR13926.1 - 3.3 6.9 5.0 5.1 6.3 5.0 1.2 1 0 0 1 1 1 0 EAP30/Vps36 family SR-25 PF10500.9 ELR13926.1 - 6 6.4 40.2 0.26 10.9 10.0 3.6 3 0 0 3 3 3 0 Nuclear RNA-splicing-associated protein SHQ1 PF04925.15 ELR13927.1 - 2.2e-58 196.7 0.1 3.3e-58 196.1 0.1 1.3 1 0 0 1 1 1 1 SHQ1 protein Vps51 PF08700.11 ELR13927.1 - 0.052 13.6 0.0 0.15 12.2 0.0 1.9 1 0 0 1 1 1 0 Vps51/Vps67 LMF1 PF06762.14 ELR13927.1 - 1.1 8.3 4.5 1.8 7.6 4.5 1.2 1 0 0 1 1 1 0 Lipase maturation factor Ycf1 PF05758.12 ELR13930.1 - 0.51 8.1 0.9 0.68 7.7 0.9 1.2 1 0 0 1 1 1 0 Ycf1 Presenilin PF01080.17 ELR13930.1 - 2.6 6.7 3.0 3.3 6.4 3.0 1.0 1 0 0 1 1 1 0 Presenilin DUF3430 PF11912.8 ELR13931.1 - 6.1e-06 26.4 1.4 1.4e-05 25.2 1.4 1.7 1 1 0 1 1 1 1 Protein of unknown function (DUF3430) Zip PF02535.22 ELR13932.1 - 3.3e-16 59.4 7.7 1e-10 41.4 0.1 2.1 2 0 0 2 2 2 2 ZIP Zinc transporter SLATT_fungal PF18142.1 ELR13932.1 - 0.046 13.7 0.2 0.097 12.7 0.2 1.5 1 0 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain Cellulase PF00150.18 ELR13933.1 - 1.8e-22 80.1 6.2 2.5e-22 79.7 6.2 1.1 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) Glyco_hydro_42 PF02449.15 ELR13933.1 - 0.0041 16.5 0.3 1.6 7.9 0.0 2.5 2 1 0 2 2 2 2 Beta-galactosidase Palm_thioest PF02089.15 ELR13934.1 - 3e-73 246.6 0.0 3.5e-73 246.4 0.0 1.0 1 0 0 1 1 1 1 Palmitoyl protein thioesterase Abhydrolase_6 PF12697.7 ELR13934.1 - 0.0033 18.1 0.0 0.004 17.8 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 ELR13934.1 - 0.026 14.1 0.0 0.071 12.7 0.0 1.7 2 0 0 2 2 2 0 alpha/beta hydrolase fold DUF915 PF06028.11 ELR13934.1 - 0.17 11.2 0.1 8.4 5.6 0.1 2.3 2 0 0 2 2 2 0 Alpha/beta hydrolase of unknown function (DUF915) WD40 PF00400.32 ELR13935.1 - 7.8e-17 61.3 8.5 1.8e-06 28.5 0.0 5.7 6 0 0 6 6 6 2 WD domain, G-beta repeat F-box-like PF12937.7 ELR13935.1 - 2e-10 40.4 1.3 4.9e-10 39.2 1.3 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ELR13935.1 - 6.8e-10 38.6 0.4 1.9e-09 37.2 0.4 1.8 1 0 0 1 1 1 1 F-box domain ANAPC4_WD40 PF12894.7 ELR13935.1 - 9.6e-08 32.2 0.0 0.44 10.9 0.0 4.8 3 1 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ELR13935.1 - 5.5e-05 22.0 0.3 0.013 14.2 0.1 3.5 3 1 0 4 4 4 1 Nucleoporin Nup120/160 Dmrt1 PF12374.8 ELR13935.1 - 7.6 7.1 21.3 7.9 7.0 11.1 3.5 2 1 1 3 3 3 0 Double-sex mab3 related transcription factor 1 adh_short PF00106.25 ELR13936.1 - 6e-47 159.6 0.0 8e-47 159.2 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ELR13936.1 - 1.8e-30 106.2 0.0 2.2e-30 105.9 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ELR13936.1 - 2.2e-10 40.7 0.0 3.3e-10 40.2 0.0 1.2 1 0 0 1 1 1 1 KR domain Sacchrp_dh_NADP PF03435.18 ELR13936.1 - 0.0085 16.4 0.1 0.018 15.3 0.1 1.5 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain Polysacc_synt_2 PF02719.15 ELR13936.1 - 0.14 11.3 0.0 0.31 10.1 0.0 1.6 2 0 0 2 2 2 0 Polysaccharide biosynthesis protein CHASE6_C PF17150.4 ELR13937.1 - 0.15 12.7 0.5 0.58 10.9 0.4 2.0 2 0 0 2 2 2 0 C-terminal domain of two-partite extracellular sensor domain F-box PF00646.33 ELR13938.1 - 7.6e-08 32.0 0.2 7.6e-08 32.0 0.2 1.7 2 0 0 2 2 1 1 F-box domain TPR_2 PF07719.17 ELR13938.1 - 9.6e-06 25.3 12.2 0.92 9.8 0.3 5.5 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_11 PF13414.6 ELR13938.1 - 6e-05 22.6 3.6 0.76 9.5 0.0 3.7 3 0 0 3 3 3 2 TPR repeat F-box-like PF12937.7 ELR13938.1 - 6.9e-05 22.7 0.6 6.9e-05 22.7 0.6 2.1 2 0 0 2 2 2 1 F-box-like TPR_1 PF00515.28 ELR13938.1 - 0.0003 20.5 10.1 0.46 10.4 1.1 4.6 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_8 PF13181.6 ELR13938.1 - 0.0014 18.7 6.4 1.5 9.3 0.3 5.1 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_12 PF13424.6 ELR13938.1 - 0.017 15.4 14.3 0.21 11.9 0.3 5.4 3 2 2 6 6 6 0 Tetratricopeptide repeat BSP_II PF05432.11 ELR13938.1 - 0.027 14.2 15.9 0.059 13.1 15.9 1.4 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) TPR_14 PF13428.6 ELR13938.1 - 0.038 14.8 7.1 2.3 9.2 0.0 5.8 6 0 0 6 6 6 0 Tetratricopeptide repeat Peptidase_M78 PF06114.13 ELR13938.1 - 0.047 13.6 2.0 0.28 11.1 1.5 2.4 2 0 0 2 2 2 0 IrrE N-terminal-like domain TPR_10 PF13374.6 ELR13938.1 - 0.066 13.1 10.3 14 5.7 0.0 5.9 6 0 0 6 6 6 0 Tetratricopeptide repeat MIT PF04212.18 ELR13938.1 - 0.19 11.8 7.8 19 5.4 0.1 4.9 3 1 1 4 4 4 0 MIT (microtubule interacting and transport) domain ANAPC3 PF12895.7 ELR13938.1 - 0.68 10.2 6.2 20 5.5 0.1 3.8 4 0 0 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 BTB PF00651.31 ELR13940.1 - 2e-08 34.4 0.0 6.6e-08 32.8 0.0 1.8 2 0 0 2 2 2 1 BTB/POZ domain tRNA_bind_2 PF13725.6 ELR13940.1 - 0.096 12.4 0.1 0.16 11.7 0.1 1.2 1 0 0 1 1 1 0 Possible tRNA binding domain EF-hand_6 PF13405.6 ELR13941.1 - 4.8e-16 57.2 9.0 3.4e-06 26.5 0.1 4.2 4 0 0 4 4 4 2 EF-hand domain EF-hand_7 PF13499.6 ELR13941.1 - 1.2e-14 54.5 7.2 2.9e-08 34.1 0.8 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 ELR13941.1 - 6.6e-12 44.1 6.3 2.4e-05 23.6 0.0 3.4 4 0 0 4 4 4 2 EF hand EF-hand_5 PF13202.6 ELR13941.1 - 3.2e-08 32.7 0.4 0.00016 21.0 0.2 3.2 4 0 0 4 4 4 2 EF hand EF-hand_8 PF13833.6 ELR13941.1 - 3.8e-08 33.0 6.8 0.00025 20.8 0.0 3.7 4 0 0 4 4 4 2 EF-hand domain pair SPARC_Ca_bdg PF10591.9 ELR13941.1 - 0.0002 21.7 6.5 0.025 14.9 0.4 2.9 2 1 1 3 3 3 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 ELR13941.1 - 0.00062 19.7 8.2 0.35 10.9 0.3 3.0 2 1 1 3 3 3 2 Cytoskeletal-regulatory complex EF hand Caleosin PF05042.13 ELR13941.1 - 0.002 18.1 0.8 1.4 8.9 0.1 2.5 2 1 0 2 2 2 2 Caleosin related protein EF-hand_10 PF14788.6 ELR13941.1 - 0.0086 15.9 0.3 13 5.7 0.0 3.2 2 1 1 3 3 3 2 EF hand EF-hand_9 PF14658.6 ELR13941.1 - 0.012 15.9 0.0 0.28 11.5 0.0 2.2 2 0 0 2 2 2 0 EF-hand domain Ras PF00071.22 ELR13942.1 - 1.7e-26 92.7 0.0 2e-26 92.5 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR13942.1 - 8.7e-19 67.9 0.0 1.6e-18 67.1 0.0 1.4 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR13942.1 - 1e-07 31.5 0.0 1.2e-07 31.4 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 ELR13942.1 - 0.00025 21.1 0.0 0.00043 20.3 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 ELR13942.1 - 0.0095 15.3 0.0 0.012 14.9 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region TniB PF05621.11 ELR13942.1 - 0.032 13.6 0.0 0.053 12.9 0.0 1.3 1 0 0 1 1 1 0 Bacterial TniB protein TsaE PF02367.17 ELR13942.1 - 0.082 12.9 0.0 0.13 12.3 0.0 1.2 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE PduV-EutP PF10662.9 ELR13942.1 - 0.15 11.8 0.0 0.21 11.3 0.0 1.2 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation Menin PF05053.13 ELR13943.1 - 0.33 9.3 11.8 0.71 8.2 11.8 1.5 1 0 0 1 1 1 0 Menin Sas10_Utp3 PF04000.15 ELR13944.1 - 2.5e-19 69.7 0.1 2.5e-19 69.7 0.1 2.7 3 0 0 3 3 3 1 Sas10/Utp3/C1D family SDA1 PF05285.12 ELR13944.1 - 0.005 16.3 23.2 0.005 16.3 23.2 2.4 2 1 0 2 2 2 1 SDA1 Histone_H2A_C PF16211.5 ELR13945.1 - 7.6e-18 64.0 1.4 7.6e-18 64.0 1.4 1.6 2 0 0 2 2 2 1 C-terminus of histone H2A Histone PF00125.24 ELR13945.1 - 3.5e-13 50.1 0.4 1.8e-12 47.8 0.0 1.9 1 1 1 2 2 2 1 Core histone H2A/H2B/H3/H4 Yip1 PF04893.17 ELR13946.1 - 5.1e-12 45.9 24.8 1.1e-11 44.8 24.8 1.5 1 1 0 1 1 1 1 Yip1 domain zf-UBP PF02148.19 ELR13947.1 - 2.6e-18 66.1 7.6 2.6e-18 66.1 7.6 2.0 2 0 0 2 2 2 1 Zn-finger in ubiquitin-hydrolases and other protein zf-UBP_var PF17807.1 ELR13947.1 - 0.0012 18.6 1.0 0.0012 18.6 1.0 2.0 2 0 0 2 2 2 1 Variant UBP zinc finger S1-P1_nuclease PF02265.16 ELR13948.1 - 1.6e-62 211.6 0.0 1.9e-62 211.4 0.0 1.0 1 0 0 1 1 1 1 S1/P1 Nuclease Lung_7-TM_R PF06814.13 ELR13950.1 - 1.4e-54 185.3 17.3 1.9e-54 184.9 17.3 1.1 1 0 0 1 1 1 1 Lung seven transmembrane receptor GpcrRhopsn4 PF10192.9 ELR13950.1 - 5.8e-05 22.6 12.0 0.00013 21.5 12.0 1.5 1 0 0 1 1 1 1 Rhodopsin-like GPCR transmembrane domain SWIM PF04434.17 ELR13952.1 - 6.9e-05 22.4 0.2 0.00013 21.5 0.2 1.5 1 0 0 1 1 1 1 SWIM zinc finger PH PF00169.29 ELR13955.1 - 1.6e-57 192.4 1.7 2e-13 50.7 0.0 5.3 5 0 0 5 5 5 5 PH domain RhoGAP PF00620.27 ELR13955.1 - 8.7e-41 139.3 0.0 1.4e-40 138.6 0.0 1.2 1 0 0 1 1 1 1 RhoGAP domain PH_11 PF15413.6 ELR13955.1 - 2.6e-06 27.8 25.9 0.47 10.9 3.9 6.5 5 4 0 5 5 5 4 Pleckstrin homology domain PH_13 PF16652.5 ELR13955.1 - 1e-05 25.4 0.6 1 9.2 0.1 4.7 5 0 0 5 5 5 2 Pleckstrin homology domain PH_9 PF15410.6 ELR13955.1 - 8.5e-05 22.9 7.8 1 9.7 0.0 5.7 5 2 1 6 6 6 2 Pleckstrin homology domain PH_16 PF17838.1 ELR13955.1 - 0.0002 21.2 6.2 0.0054 16.6 0.2 4.0 5 0 0 5 5 5 2 PH domain F-box-like PF12937.7 ELR13956.1 - 0.073 13.0 0.6 0.46 10.4 0.6 2.2 1 1 0 1 1 1 0 F-box-like Elongin_A PF06881.11 ELR13956.1 - 0.08 13.5 0.2 0.12 12.9 0.2 1.3 1 0 0 1 1 1 0 RNA polymerase II transcription factor SIII (Elongin) subunit A CDC24_OB3 PF17244.2 ELR13957.1 - 1.7e-36 126.0 0.0 3.5e-29 102.1 0.0 2.6 2 1 1 3 3 3 2 Cell division control protein 24, OB domain 3 CDC24_OB1 PF17246.2 ELR13957.1 - 7e-32 110.1 0.0 1.2e-31 109.3 0.0 1.4 1 0 0 1 1 1 1 Cell division control protein 24, OB domain 1 CDC24_OB2 PF17245.2 ELR13957.1 - 5e-26 91.8 1.0 2.7e-25 89.4 0.8 2.1 1 1 1 2 2 2 1 Cell division control protein 24, OB domain 2 Rep_fac-A_C PF08646.10 ELR13957.1 - 0.0057 16.4 0.1 0.012 15.3 0.1 1.5 1 0 0 1 1 1 1 Replication factor-A C terminal domain Cyt-b5 PF00173.28 ELR13958.1 - 2.5e-24 85.2 0.2 2.9e-24 85.0 0.2 1.1 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Beach PF02138.18 ELR13959.1 - 3.9e-115 384.0 0.0 6.6e-115 383.2 0.0 1.4 1 0 0 1 1 1 1 Beige/BEACH domain PH_BEACH PF14844.6 ELR13959.1 - 4.1e-16 58.9 0.2 3.6e-15 55.9 0.0 3.0 2 0 0 2 2 2 1 PH domain associated with Beige/BEACH WD40 PF00400.32 ELR13959.1 - 1.7e-06 28.7 10.8 0.89 10.5 0.0 5.9 5 0 0 5 5 5 3 WD domain, G-beta repeat Laminin_G_3 PF13385.6 ELR13959.1 - 3.5e-06 27.3 0.0 0.00015 21.9 0.0 2.5 1 1 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily DUF4704 PF15787.5 ELR13959.1 - 0.0015 17.8 6.3 0.3 10.3 0.0 4.9 6 0 0 6 6 6 2 Domain of unknown function (DUF4704) ANAPC4_WD40 PF12894.7 ELR13959.1 - 0.0062 16.8 0.0 1.5 9.2 0.0 3.2 2 1 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain GRAM PF02893.20 ELR13959.1 - 0.021 14.7 0.0 0.13 12.2 0.0 2.2 1 1 0 1 1 1 0 GRAM domain zf-XS PF03470.14 ELR13959.1 - 0.14 12.4 0.2 0.73 10.2 0.2 2.4 1 0 0 1 1 1 0 XS zinc finger domain ADP_ribosyl_GH PF03747.14 ELR13961.1 - 4.7e-34 118.4 0.0 5.8e-34 118.2 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylglycohydrolase U3_assoc_6 PF08640.11 ELR13962.1 - 3.9e-27 94.1 9.4 4.6e-26 90.7 1.9 3.7 4 0 0 4 4 4 1 U3 small nucleolar RNA-associated protein 6 NRDE-2 PF08424.10 ELR13962.1 - 6.2e-11 42.0 7.1 0.0034 16.6 0.0 4.8 2 1 2 4 4 4 3 NRDE-2, necessary for RNA interference TPR_14 PF13428.6 ELR13962.1 - 7.9e-11 41.8 11.9 0.014 16.2 0.1 6.9 5 2 2 7 7 7 3 Tetratricopeptide repeat TPR_19 PF14559.6 ELR13962.1 - 2.5e-08 34.3 0.5 0.33 11.5 0.1 5.5 7 0 0 7 7 7 2 Tetratricopeptide repeat Suf PF05843.14 ELR13962.1 - 2.9e-06 27.5 3.8 0.0087 16.1 0.0 3.8 4 0 0 4 4 4 2 Suppressor of forked protein (Suf) TPR_16 PF13432.6 ELR13962.1 - 4.9e-06 27.1 6.6 0.0071 17.0 0.2 4.1 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.17 ELR13962.1 - 0.00027 20.8 2.3 0.18 12.0 0.1 4.8 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_8 PF13181.6 ELR13962.1 - 0.0015 18.5 0.8 5.5 7.5 0.1 4.3 4 0 0 4 4 4 1 Tetratricopeptide repeat Bromodomain PF00439.25 ELR13962.1 - 0.068 13.3 0.1 16 5.7 0.1 2.9 2 0 0 2 2 2 0 Bromodomain ParD_antitoxin PF03693.14 ELR13962.1 - 0.13 12.7 0.0 0.36 11.3 0.0 1.8 1 0 0 1 1 1 0 Bacterial antitoxin of ParD toxin-antitoxin type II system and RHH Ecm29 PF13001.7 ELR13963.1 - 1.8e-43 149.0 0.9 1.1e-25 90.3 0.3 2.0 2 0 0 2 2 2 2 Proteasome stabiliser HEAT_EZ PF13513.6 ELR13964.1 - 2.4e-09 37.5 17.8 0.17 12.4 0.0 10.3 10 2 1 11 11 11 3 HEAT-like repeat Cnd1 PF12717.7 ELR13964.1 - 6.1e-07 29.6 0.1 0.015 15.3 0.0 3.9 4 1 1 5 5 5 2 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 ELR13964.1 - 0.0066 16.8 16.1 3.1 8.2 0.1 8.3 9 1 1 10 10 9 1 HEAT repeats HEAT PF02985.22 ELR13964.1 - 0.0082 16.3 17.0 19 5.8 0.0 9.7 14 0 0 14 14 13 0 HEAT repeat Vac14_Fab1_bd PF12755.7 ELR13964.1 - 0.027 15.1 0.0 1.8 9.2 0.0 3.7 2 1 1 3 3 3 0 Vacuolar 14 Fab1-binding region Adaptin_N PF01602.20 ELR13964.1 - 0.033 12.8 8.4 0.91 8.0 0.4 4.5 5 1 0 5 5 5 0 Adaptin N terminal region Cohesin_HEAT PF12765.7 ELR13964.1 - 0.045 14.1 2.4 35 4.8 0.0 4.3 4 0 0 4 4 4 0 HEAT repeat associated with sister chromatid cohesion MMS19_C PF12460.8 ELR13964.1 - 0.069 12.3 4.1 2.3 7.3 0.0 3.9 4 0 0 4 4 4 0 RNAPII transcription regulator C-terminal Ecm29 PF13001.7 ELR13964.1 - 0.39 9.3 4.2 3 6.4 0.0 4.1 6 0 0 6 6 6 0 Proteasome stabiliser Arm PF00514.23 ELR13964.1 - 0.7 10.0 2.5 18 5.6 0.0 4.5 5 0 0 5 5 5 0 Armadillo/beta-catenin-like repeat SLX9 PF15341.6 ELR13964.1 - 3.1 8.2 6.2 0.8 10.1 0.1 2.4 2 0 0 2 2 2 0 Ribosome biogenesis protein SLX9 RNA_pol_Rpb8 PF03870.15 ELR13965.1 - 1.5e-49 167.7 0.7 1.7e-49 167.6 0.7 1.0 1 0 0 1 1 1 1 RNA polymerase Rpb8 RNA_pol_RpbG PF16992.5 ELR13965.1 - 1.5e-05 25.0 1.0 0.0013 18.8 1.0 2.0 1 1 0 1 1 1 1 DNA-directed RNA polymerase, subunit G UQ_con PF00179.26 ELR13967.1 - 5.8e-25 87.6 0.0 6.8e-25 87.4 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Yop-YscD_cpl PF16697.5 ELR13968.1 - 6.6e-07 29.6 0.0 1.5e-06 28.4 0.0 1.6 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain FHA PF00498.26 ELR13968.1 - 7.1e-07 29.5 0.0 1.3e-06 28.6 0.0 1.4 1 0 0 1 1 1 1 FHA domain Esterase_phd PF10503.9 ELR13969.1 - 2.1e-08 34.0 1.0 3.9e-05 23.3 0.2 2.3 2 0 0 2 2 2 2 Esterase PHB depolymerase Abhydrolase_3 PF07859.13 ELR13969.1 - 0.059 13.2 0.0 0.11 12.3 0.0 1.5 1 0 0 1 1 1 0 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 ELR13969.1 - 0.085 12.3 0.6 0.16 11.4 0.6 1.4 1 0 0 1 1 1 0 Prolyl oligopeptidase family UCH PF00443.29 ELR13971.1 - 1e-48 166.1 0.5 2.9e-48 164.6 0.5 1.9 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 ELR13971.1 - 1.5e-34 120.1 1.5 2.4e-34 119.4 0.8 1.7 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase ubiquitin PF00240.23 ELR13971.1 - 2.7e-11 43.1 0.1 6.5e-11 41.8 0.1 1.6 1 0 0 1 1 1 1 Ubiquitin family FANCI_S1 PF14675.6 ELR13971.1 - 0.0067 16.0 0.5 5.3 6.5 0.1 4.0 4 0 0 4 4 4 1 FANCI solenoid 1 USP7_ICP0_bdg PF12436.8 ELR13971.1 - 0.015 14.6 0.0 0.04 13.2 0.0 1.7 1 0 0 1 1 1 0 ICP0-binding domain of Ubiquitin-specific protease 7 DUF3517 PF12030.8 ELR13971.1 - 0.053 12.4 0.4 0.31 9.9 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF3517) DUF4611 PF15387.6 ELR13971.1 - 0.059 13.6 1.1 5.4 7.3 0.1 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4611) GTP_cyclohydroI PF01227.22 ELR13971.1 - 0.13 11.7 0.0 0.3 10.5 0.0 1.6 1 0 0 1 1 1 0 GTP cyclohydrolase I Ras PF00071.22 ELR13973.1 - 1.5e-27 96.1 0.0 1.1e-25 90.1 0.0 2.2 1 1 0 1 1 1 1 Ras family Ank_2 PF12796.7 ELR13973.1 - 7.5e-17 61.7 0.1 5e-13 49.4 0.0 2.4 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 ELR13973.1 - 1.5e-15 55.7 0.1 6.4e-05 23.1 0.0 4.3 4 0 0 4 4 4 2 Ankyrin repeat Ank_4 PF13637.6 ELR13973.1 - 6.8e-14 52.0 0.4 4.1e-06 27.2 0.0 3.8 3 0 0 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.30 ELR13973.1 - 8.4e-14 51.3 4.9 2.9e-06 27.5 0.3 4.0 4 0 0 4 4 4 2 Ankyrin repeat Ank_5 PF13857.6 ELR13973.1 - 8.1e-12 45.1 1.1 1.7e-06 28.1 0.0 3.5 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Roc PF08477.13 ELR13973.1 - 6.6e-11 42.5 0.1 8.1e-09 35.7 0.1 2.3 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase F-box-like PF12937.7 ELR13973.1 - 9.5e-09 35.0 4.1 1.9e-08 34.1 4.1 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ELR13973.1 - 6.8e-05 22.6 4.8 0.00013 21.8 4.8 1.5 1 0 0 1 1 1 1 F-box domain F-box_4 PF15966.5 ELR13973.1 - 0.00015 21.7 0.6 0.00025 20.9 0.6 1.4 1 0 0 1 1 1 1 F-box HEAT_2 PF13646.6 ELR13974.1 - 2e-05 24.9 1.4 0.019 15.3 0.0 4.1 2 1 2 4 4 4 2 HEAT repeats HEAT PF02985.22 ELR13974.1 - 0.0018 18.3 6.4 1.2 9.5 0.1 5.3 4 0 0 4 4 4 1 HEAT repeat Malate_synthase PF01274.22 ELR13974.1 - 0.0061 14.9 0.0 0.01 14.2 0.0 1.2 1 0 0 1 1 1 1 Malate synthase RTP1_C1 PF10363.9 ELR13974.1 - 0.017 15.3 0.0 0.85 9.8 0.0 2.9 2 0 0 2 2 2 0 Required for nuclear transport of RNA pol II C-terminus 1 SDA1 PF05285.12 ELR13974.1 - 0.038 13.4 33.6 0.1 12.0 33.6 1.6 1 0 0 1 1 1 0 SDA1 HEAT_EZ PF13513.6 ELR13974.1 - 0.043 14.3 7.5 22 5.7 0.1 4.9 4 0 0 4 4 4 0 HEAT-like repeat Arm PF00514.23 ELR13974.1 - 0.55 10.4 2.7 1.8 8.7 0.7 2.9 2 0 0 2 2 2 0 Armadillo/beta-catenin-like repeat Nop14 PF04147.12 ELR13974.1 - 1.7 6.8 39.9 2.6 6.1 39.9 1.2 1 0 0 1 1 1 0 Nop14-like family PQQ_2 PF13360.6 ELR13975.1 - 0.00028 20.5 0.1 0.065 12.8 0.1 2.8 2 0 0 2 2 2 2 PQQ-like domain PQQ_3 PF13570.6 ELR13975.1 - 0.048 14.1 0.6 4.9 7.8 0.2 4.3 4 0 0 4 4 4 0 PQQ-like domain WD40 PF00400.32 ELR13975.1 - 0.098 13.6 4.9 0.52 11.3 0.1 4.4 5 0 0 5 5 5 0 WD domain, G-beta repeat TPR_19 PF14559.6 ELR13975.1 - 2.1 8.9 6.1 9 6.9 0.2 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat Pro_CA PF00484.19 ELR13977.1 - 1.9e-31 109.5 0.3 2.4e-31 109.1 0.3 1.1 1 0 0 1 1 1 1 Carbonic anhydrase FAD_binding_1 PF00667.20 ELR13978.1 - 5.2e-50 170.1 0.0 1.5e-49 168.5 0.0 1.8 2 0 0 2 2 2 1 FAD binding domain Flavodoxin_1 PF00258.25 ELR13978.1 - 1.2e-32 113.0 0.0 3.1e-32 111.8 0.0 1.7 2 0 0 2 2 2 1 Flavodoxin NAD_binding_1 PF00175.21 ELR13978.1 - 2.9e-07 31.1 0.0 5.7e-07 30.2 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain Lentivirus_VIF PF05851.11 ELR13978.1 - 0.052 12.5 0.0 0.095 11.6 0.0 1.3 1 0 0 1 1 1 0 Lentivirus virion infectivity factor (VIF) Flavodoxin_5 PF12724.7 ELR13978.1 - 0.21 11.8 0.5 6.4 7.0 0.0 3.1 3 1 1 4 4 4 0 Flavodoxin domain Cytokin_check_N PF10407.9 ELR13979.1 - 1e-12 47.8 0.0 1.9e-12 47.0 0.0 1.4 1 0 0 1 1 1 1 Cdc14 phosphatase binding protein N-terminus Pkinase PF00069.25 ELR13981.1 - 2.8e-56 190.8 0.0 4e-56 190.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR13981.1 - 1.4e-20 73.7 0.0 2.2e-20 73.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 ELR13981.1 - 2.1e-05 24.6 0.0 3.9e-05 23.7 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family RIO1 PF01163.22 ELR13981.1 - 0.009 15.6 0.1 0.016 14.8 0.1 1.4 1 0 0 1 1 1 1 RIO1 family Choline_kinase PF01633.20 ELR13981.1 - 0.0096 15.5 0.1 0.015 14.9 0.1 1.2 1 0 0 1 1 1 1 Choline/ethanolamine kinase Kdo PF06293.14 ELR13981.1 - 0.046 13.1 0.0 0.098 12.0 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family AAA PF00004.29 ELR13982.1 - 9.3e-42 142.6 0.0 1.8e-41 141.6 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 ELR13982.1 - 1.8e-10 40.5 0.4 3.3e-10 39.6 0.4 1.4 1 0 0 1 1 1 1 AAA+ lid domain Prot_ATP_ID_OB PF16450.5 ELR13982.1 - 3e-08 33.5 0.1 6e-08 32.5 0.1 1.5 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain AAA_2 PF07724.14 ELR13982.1 - 2.9e-06 27.5 0.0 7.3e-06 26.2 0.0 1.6 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.6 ELR13982.1 - 6.9e-06 26.4 0.2 0.013 15.8 0.1 2.5 1 1 1 2 2 2 2 AAA domain DUF815 PF05673.13 ELR13982.1 - 2.6e-05 23.5 0.0 4.4e-05 22.8 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_16 PF13191.6 ELR13982.1 - 3.6e-05 24.2 0.1 0.002 18.5 0.0 2.4 1 1 1 2 2 2 1 AAA ATPase domain AAA_5 PF07728.14 ELR13982.1 - 4.6e-05 23.5 0.1 0.00022 21.2 0.1 2.1 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) RuvB_N PF05496.12 ELR13982.1 - 0.0008 19.2 0.0 0.0016 18.2 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain ATPase PF06745.13 ELR13982.1 - 0.0073 15.7 0.1 0.39 10.0 0.1 2.4 1 1 0 2 2 2 1 KaiC TIP49 PF06068.13 ELR13982.1 - 0.018 14.2 0.0 0.034 13.3 0.0 1.4 1 0 0 1 1 1 0 TIP49 P-loop domain RNA_helicase PF00910.22 ELR13982.1 - 0.025 15.0 0.0 0.05 14.0 0.0 1.5 1 0 0 1 1 1 0 RNA helicase AAA_3 PF07726.11 ELR13982.1 - 0.025 14.4 0.0 0.071 13.0 0.0 1.7 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) IstB_IS21 PF01695.17 ELR13982.1 - 0.026 14.3 0.0 0.049 13.4 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_18 PF13238.6 ELR13982.1 - 0.032 14.8 0.6 0.085 13.4 0.0 2.0 3 0 0 3 3 2 0 AAA domain NACHT PF05729.12 ELR13982.1 - 0.044 13.7 0.1 0.28 11.1 0.0 2.1 1 1 1 2 2 2 0 NACHT domain Sigma54_activat PF00158.26 ELR13982.1 - 0.046 13.4 0.0 0.18 11.5 0.0 1.9 3 0 0 3 3 2 0 Sigma-54 interaction domain AAA_25 PF13481.6 ELR13982.1 - 0.058 13.0 0.5 0.82 9.2 0.2 2.3 1 1 1 2 2 2 0 AAA domain AAA_24 PF13479.6 ELR13982.1 - 0.058 13.1 0.8 0.13 12.0 0.3 2.0 2 1 0 2 2 2 0 AAA domain TsaE PF02367.17 ELR13982.1 - 0.062 13.3 0.0 0.11 12.5 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Mg_chelatase PF01078.21 ELR13982.1 - 0.073 12.4 0.0 0.14 11.5 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI NB-ARC PF00931.22 ELR13982.1 - 0.1 11.8 0.1 0.75 8.9 0.0 2.1 2 0 0 2 2 2 0 NB-ARC domain AAA_33 PF13671.6 ELR13982.1 - 0.12 12.6 0.0 0.21 11.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain PhoH PF02562.16 ELR13982.1 - 0.12 11.8 0.1 0.37 10.2 0.0 1.7 2 0 0 2 2 2 0 PhoH-like protein Prot_ATP_OB_N PF17758.1 ELR13982.1 - 0.12 12.0 0.1 0.51 10.0 0.0 2.1 2 0 0 2 2 1 0 Proteasomal ATPase OB N-terminal domain AAA_7 PF12775.7 ELR13982.1 - 0.14 11.7 0.1 0.36 10.3 0.1 1.7 1 1 0 1 1 1 0 P-loop containing dynein motor region AAA_28 PF13521.6 ELR13982.1 - 0.15 12.3 0.3 0.29 11.4 0.0 1.6 2 0 0 2 2 1 0 AAA domain TPR_14 PF13428.6 ELR13983.1 - 2.7e-09 37.0 21.5 0.061 14.2 0.5 9.9 3 2 8 11 11 11 4 Tetratricopeptide repeat TPR_19 PF14559.6 ELR13983.1 - 3.9e-08 33.7 7.2 0.7 10.4 0.0 6.2 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_17 PF13431.6 ELR13983.1 - 1e-05 25.6 0.0 1.6 9.3 0.0 5.9 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_9 PF13371.6 ELR13983.1 - 0.002 18.2 9.0 7.9 6.7 0.0 5.4 5 0 0 5 5 5 1 Tetratricopeptide repeat TFIIA PF03153.13 ELR13983.1 - 0.0084 16.1 30.7 0.016 15.3 30.7 1.5 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit TPR_8 PF13181.6 ELR13983.1 - 0.11 12.7 0.0 18 5.8 0.0 3.4 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_16 PF13432.6 ELR13983.1 - 0.16 12.6 17.6 0.37 11.5 0.3 6.1 5 2 2 7 7 7 0 Tetratricopeptide repeat Suf PF05843.14 ELR13983.1 - 0.37 10.7 0.0 0.37 10.7 0.0 4.0 3 1 1 4 4 4 0 Suppressor of forked protein (Suf) TPR_2 PF07719.17 ELR13983.1 - 1.2 9.4 14.7 33 4.9 0.1 7.6 10 0 0 10 10 10 0 Tetratricopeptide repeat EF-hand_6 PF13405.6 ELR13985.1 - 5.7e-08 32.1 1.0 0.00015 21.4 0.0 3.5 4 0 0 4 4 4 2 EF-hand domain EF-hand_7 PF13499.6 ELR13985.1 - 7.2e-08 32.8 0.4 7.6e-05 23.1 0.0 3.3 3 1 0 3 3 3 1 EF-hand domain pair EF-hand_8 PF13833.6 ELR13985.1 - 5.5e-07 29.3 2.2 0.018 14.9 0.1 4.0 4 0 0 4 4 4 2 EF-hand domain pair EF-hand_1 PF00036.32 ELR13985.1 - 2.5e-06 26.6 0.5 0.00064 19.1 0.0 3.6 4 0 0 4 4 4 1 EF hand EF-hand_9 PF14658.6 ELR13985.1 - 0.0015 18.8 0.0 0.0082 16.4 0.0 2.1 2 0 0 2 2 2 1 EF-hand domain Amidase PF01425.21 ELR13985.1 - 0.15 11.0 0.0 0.17 10.8 0.0 1.0 1 0 0 1 1 1 0 Amidase GSHPx PF00255.19 ELR13986.1 - 1.8e-48 162.6 0.8 2.2e-48 162.3 0.8 1.1 1 0 0 1 1 1 1 Glutathione peroxidase AhpC-TSA PF00578.21 ELR13986.1 - 4.6e-08 33.0 0.2 1.2e-07 31.6 0.2 1.8 1 1 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 ELR13986.1 - 3e-06 27.0 0.0 4.8e-06 26.3 0.0 1.5 1 1 0 1 1 1 1 Redoxin FERM_F1 PF18379.1 ELR13986.1 - 0.17 11.9 0.0 0.3 11.1 0.0 1.4 1 0 0 1 1 1 0 FERM F1 ubiquitin-like domain S4 PF01479.25 ELR13987.1 - 2.4e-12 46.4 1.0 7.4e-12 44.8 1.0 1.9 1 0 0 1 1 1 1 S4 domain Ribosomal_S4 PF00163.19 ELR13987.1 - 3e-05 24.9 0.7 5.7e-05 23.9 0.1 1.9 1 1 1 2 2 2 1 Ribosomal protein S4/S9 N-terminal domain TEX19 PF15553.6 ELR13988.1 - 0.023 14.7 2.0 0.044 13.8 2.0 1.4 1 0 0 1 1 1 0 Testis-expressed protein 19 Neur_chan_memb PF02932.16 ELR13988.1 - 0.12 12.4 1.9 0.22 11.5 1.9 1.4 1 1 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region HATPase_c PF02518.26 ELR13989.1 - 3e-48 163.0 0.1 1.2e-26 93.4 0.0 2.5 2 0 0 2 2 2 2 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 ELR13989.1 - 3.8e-29 101.1 3.0 1.7e-13 50.7 0.1 3.9 3 1 0 3 3 3 3 Response regulator receiver domain HisKA PF00512.25 ELR13989.1 - 2.5e-15 56.2 0.9 2.9e-12 46.4 0.1 3.2 2 1 1 3 3 3 2 His Kinase A (phospho-acceptor) domain CrgA PF06781.12 ELR13989.1 - 0.066 13.3 0.0 0.78 9.8 0.0 2.7 2 0 0 2 2 2 0 Cell division protein CrgA DUF3464 PF11947.8 ELR13989.1 - 8 6.2 5.8 38 4.0 2.0 2.8 2 0 0 2 2 2 0 Photosynthesis affected mutant 68 DUF846 PF05832.12 ELR13990.1 - 1e-48 164.9 12.5 1.2e-48 164.7 12.5 1.1 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF846) TRAP-gamma PF07074.12 ELR13990.1 - 0.12 11.9 5.6 1.8 8.1 0.7 2.1 2 0 0 2 2 2 0 Translocon-associated protein, gamma subunit (TRAP-gamma) PHD PF00628.29 ELR13991.1 - 9.7e-13 47.8 41.8 2.1e-08 33.9 13.1 4.5 2 1 1 3 3 3 3 PHD-finger PHD_4 PF16866.5 ELR13991.1 - 0.0095 16.0 7.3 0.0095 16.0 7.3 5.3 3 2 3 6 6 6 1 PHD-finger SAPS PF04499.15 ELR13991.1 - 0.018 13.8 0.3 0.018 13.8 0.3 1.4 2 0 0 2 2 2 0 SIT4 phosphatase-associated protein Coilin_N PF15862.5 ELR13991.1 - 0.61 9.9 20.6 0.04 13.7 12.9 2.3 2 0 0 2 2 2 0 Coilin N-terminus Hid1 PF12722.7 ELR13991.1 - 0.78 7.8 8.1 1.2 7.2 8.1 1.2 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Rrn6 PF10214.9 ELR13991.1 - 2.1 6.7 11.5 0.073 11.6 2.9 2.1 2 0 0 2 2 2 0 RNA polymerase I-specific transcription-initiation factor CDC45 PF02724.14 ELR13991.1 - 3.7 5.7 31.2 10 4.3 0.1 2.1 2 0 0 2 2 2 0 CDC45-like protein DDHD PF02862.17 ELR13991.1 - 4.7 7.3 5.5 3 7.9 2.6 2.0 2 0 0 2 2 2 0 DDHD domain Q_salvage PF10343.9 ELR13992.1 - 8.3e-111 370.1 0.0 5.1e-90 301.9 0.0 2.0 1 1 1 2 2 2 2 Potential Queuosine, Q, salvage protein family DUF1688 PF07958.11 ELR13992.1 - 0.0015 17.3 0.0 0.97 8.1 0.0 2.4 1 1 1 2 2 2 2 Protein of unknown function (DUF1688) Macoilin PF09726.9 ELR13993.1 - 1 7.8 24.9 1.4 7.4 24.9 1.2 1 0 0 1 1 1 0 Macoilin family DUF572 PF04502.13 ELR13995.1 - 0.046 13.3 28.3 0.063 12.9 28.3 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) BUD22 PF09073.10 ELR13995.1 - 1.8 7.8 40.4 0.67 9.2 37.9 1.5 2 0 0 2 2 2 0 BUD22 TIMELESS_C PF05029.13 ELR13995.1 - 8.8 5.3 33.5 13 4.7 33.5 1.2 1 0 0 1 1 1 0 Timeless protein C terminal region CBS PF00571.28 ELR13996.1 - 1.2e-17 64.0 3.0 2.1e-05 24.9 0.1 4.1 4 0 0 4 4 4 3 CBS domain BiPBP_C PF06832.12 ELR13996.1 - 0.79 9.8 2.6 0.79 9.8 0.0 2.2 3 0 0 3 3 3 0 Penicillin-Binding Protein C-terminus Family Pkinase_Tyr PF07714.17 ELR13997.1 - 1.7e-53 181.5 0.0 2.5e-53 181.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ELR13997.1 - 3.1e-39 134.9 0.0 4.5e-39 134.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_fungal PF17667.1 ELR13997.1 - 0.00087 18.2 1.0 0.0012 17.7 0.0 1.6 2 0 0 2 2 2 1 Fungal protein kinase Kdo PF06293.14 ELR13997.1 - 0.015 14.7 0.0 0.023 14.1 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Nop14 PF04147.12 ELR13997.1 - 0.1 10.8 4.9 0.15 10.3 4.9 1.1 1 0 0 1 1 1 0 Nop14-like family CDC45 PF02724.14 ELR13997.1 - 0.63 8.3 6.2 1.2 7.3 6.2 1.4 1 0 0 1 1 1 0 CDC45-like protein NOA36 PF06524.12 ELR13997.1 - 3.1 7.0 7.7 5.8 6.1 7.7 1.4 1 0 0 1 1 1 0 NOA36 protein SDA1 PF05285.12 ELR13997.1 - 3.1 7.1 11.2 0.18 11.2 5.9 1.6 2 0 0 2 2 2 0 SDA1 Trypan_PARP PF05887.11 ELR13997.1 - 3.5 7.6 10.3 11 6.0 10.3 1.8 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) TRAP_alpha PF03896.16 ELR13997.1 - 3.7 6.7 7.4 9 5.4 6.9 1.8 2 0 0 2 2 2 0 Translocon-associated protein (TRAP), alpha subunit Orf78 PF06024.12 ELR13997.1 - 4.5 7.6 4.5 16 5.9 0.0 2.3 2 0 0 2 2 2 0 Orf78 (ac78) RNA_pol_Rpc82 PF05645.13 ELR13998.1 - 1.3e-18 67.7 0.0 2.2e-18 66.9 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase III subunit RPC82 HTH_9 PF08221.11 ELR13998.1 - 1.9e-17 63.1 1.9 2.3e-14 53.2 0.3 2.5 2 0 0 2 2 2 2 RNA polymerase III subunit RPC82 helix-turn-helix domain TFIIE_alpha PF02002.17 ELR13998.1 - 0.0025 17.7 0.2 5.7 6.9 0.0 3.2 3 0 0 3 3 3 2 TFIIE alpha subunit zf-CCHC PF00098.23 ELR13999.1 - 2.2e-07 30.7 1.7 4.3e-07 29.7 1.7 1.5 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_2 PF13696.6 ELR13999.1 - 0.00021 21.0 0.9 0.00042 20.1 0.9 1.5 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_4 PF14392.6 ELR13999.1 - 0.0028 17.4 0.2 0.0059 16.3 0.2 1.6 1 0 0 1 1 1 1 Zinc knuckle PSP PF04046.16 ELR13999.1 - 0.0076 16.1 0.0 0.014 15.2 0.0 1.4 1 0 0 1 1 1 1 PSP zf-CCHC_3 PF13917.6 ELR13999.1 - 0.19 11.7 0.2 0.19 11.7 0.2 1.7 2 0 0 2 2 2 0 Zinc knuckle Nup35_RRM PF05172.13 ELR14000.1 - 5.2e-13 48.8 0.1 2.3e-06 27.5 0.0 2.2 1 1 1 2 2 2 2 Nup53/35/40-type RNA recognition motif Nup35_RRM_2 PF14605.6 ELR14000.1 - 4.5e-05 23.4 0.0 8.2e-05 22.5 0.0 1.4 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif SNF2_N PF00176.23 ELR14001.1 - 1.7e-55 188.2 2.0 5.3e-53 180.0 0.0 2.9 2 1 1 3 3 3 2 SNF2 family N-terminal domain Helicase_C PF00271.31 ELR14001.1 - 3.3e-17 62.8 0.0 3.5e-16 59.5 0.0 2.6 3 0 0 3 3 3 1 Helicase conserved C-terminal domain HDA2-3 PF11496.8 ELR14001.1 - 0.00015 21.0 0.0 0.0012 18.0 0.0 2.6 1 1 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 zf-RanBP PF00641.18 ELR14001.1 - 0.00036 19.8 2.7 0.00072 18.8 2.7 1.4 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others ResIII PF04851.15 ELR14001.1 - 0.00076 19.5 1.6 0.0095 16.0 0.0 3.3 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit DZR PF12773.7 ELR14001.1 - 0.19 11.8 1.1 0.41 10.7 1.1 1.5 1 0 0 1 1 1 0 Double zinc ribbon NosD PF05048.13 ELR14002.1 - 0.022 14.0 0.4 0.045 13.0 0.2 1.3 1 1 0 1 1 1 0 Periplasmic copper-binding protein (NosD) Chlam_PMP PF02415.17 ELR14002.1 - 0.041 14.4 9.7 2.5 8.8 0.2 4.2 4 0 0 4 4 4 0 Chlamydia polymorphic membrane protein (Chlamydia_PMP) repeat WD40 PF00400.32 ELR14003.1 - 3.7e-08 33.9 13.4 0.074 14.0 0.3 5.2 5 1 0 5 5 5 4 WD domain, G-beta repeat F-box-like PF12937.7 ELR14003.1 - 2.8e-05 23.9 0.1 0.00018 21.3 0.1 2.3 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 ELR14003.1 - 0.0061 16.4 0.0 0.011 15.6 0.0 1.4 1 0 0 1 1 1 1 F-box domain tRNA_U5-meth_tr PF05958.11 ELR14004.1 - 9e-13 47.9 0.0 4e-12 45.8 0.0 1.9 1 1 0 1 1 1 1 tRNA (Uracil-5-)-methyltransferase Methyltransf_31 PF13847.6 ELR14004.1 - 3.9e-12 46.2 0.0 7.1e-12 45.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ELR14004.1 - 3.5e-08 34.0 0.0 2.4e-07 31.4 0.0 2.4 2 0 0 2 2 2 1 Methyltransferase domain Ubie_methyltran PF01209.18 ELR14004.1 - 8.6e-05 22.0 0.0 0.00017 21.0 0.0 1.4 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family MTS PF05175.14 ELR14004.1 - 0.00027 20.5 0.0 0.00063 19.3 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase small domain RRM_1 PF00076.22 ELR14004.1 - 0.00031 20.5 0.1 0.00077 19.2 0.1 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Methyltransf_4 PF02390.17 ELR14004.1 - 0.00075 19.0 0.0 0.0014 18.1 0.0 1.4 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_12 PF08242.12 ELR14004.1 - 0.0013 19.4 0.0 0.0039 17.9 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 ELR14004.1 - 0.0027 17.2 0.1 0.0053 16.2 0.1 1.4 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Cons_hypoth95 PF03602.15 ELR14004.1 - 0.0053 16.4 0.0 0.012 15.3 0.0 1.6 1 0 0 1 1 1 1 Conserved hypothetical protein 95 Methyltransf_32 PF13679.6 ELR14004.1 - 0.017 15.1 0.0 0.048 13.7 0.0 1.8 1 0 0 1 1 1 0 Methyltransferase domain N6_Mtase PF02384.16 ELR14004.1 - 0.027 13.7 0.0 0.063 12.5 0.0 1.5 2 0 0 2 2 2 0 N-6 DNA Methylase UPF0020 PF01170.18 ELR14004.1 - 0.057 13.1 0.1 0.16 11.6 0.1 1.8 1 1 0 1 1 1 0 Putative RNA methylase family UPF0020 Methyltransf_11 PF08241.12 ELR14004.1 - 0.061 14.0 0.0 0.25 12.0 0.0 2.1 1 0 0 1 1 1 0 Methyltransferase domain Sec1 PF00995.23 ELR14005.1 - 1.3e-132 444.0 0.4 1.5e-132 443.8 0.4 1.0 1 0 0 1 1 1 1 Sec1 family Ribosomal_L11_N PF03946.14 ELR14005.1 - 0.02 14.7 0.0 0.043 13.7 0.0 1.5 1 0 0 1 1 1 0 Ribosomal protein L11, N-terminal domain V-ATPase_H_C PF11698.8 ELR14005.1 - 0.078 13.1 0.2 0.24 11.5 0.2 1.8 1 0 0 1 1 1 0 V-ATPase subunit H DUF2935 PF11155.8 ELR14005.1 - 0.082 13.2 0.1 0.28 11.5 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF2935) Pirin_C PF05726.13 ELR14006.1 - 1.9e-27 95.7 0.0 5.4e-27 94.2 0.0 1.8 2 0 0 2 2 2 1 Pirin C-terminal cupin domain Pirin PF02678.16 ELR14006.1 - 2.5e-23 82.1 0.4 1.2e-16 60.6 0.0 2.6 2 0 0 2 2 2 2 Pirin Pirin_C_2 PF17954.1 ELR14006.1 - 0.048 13.8 0.0 0.1 12.8 0.0 1.5 1 0 0 1 1 1 0 Quercetinase C-terminal cupin domain PB1 PF00564.24 ELR14008.1 - 1.1e-13 50.9 0.0 4.5e-13 48.9 0.0 2.0 2 0 0 2 2 2 1 PB1 domain Het-C PF07217.11 ELR14008.1 - 0.18 10.3 0.2 0.23 9.9 0.2 1.1 1 0 0 1 1 1 0 Heterokaryon incompatibility protein Het-C Pirin PF02678.16 ELR14009.1 - 3.1e-34 117.2 0.4 6.9e-34 116.1 0.1 1.8 2 0 0 2 2 2 1 Pirin Pirin_C PF05726.13 ELR14009.1 - 1e-25 90.1 0.0 2.4e-25 88.9 0.0 1.7 1 0 0 1 1 1 1 Pirin C-terminal cupin domain Glyco_transf_18 PF15024.6 ELR14009.1 - 0.074 11.6 0.0 0.1 11.2 0.0 1.1 1 0 0 1 1 1 0 Glycosyltransferase family 18 Cupin_2 PF07883.11 ELR14009.1 - 0.11 12.2 0.1 0.36 10.6 0.1 1.8 1 0 0 1 1 1 0 Cupin domain PDDEXK_1 PF12705.7 ELR14010.1 - 3.7e-05 23.8 0.6 0.00011 22.2 0.6 1.7 1 1 0 1 1 1 1 PD-(D/E)XK nuclease superfamily Csa1 PF06023.12 ELR14010.1 - 0.026 13.9 0.1 0.087 12.2 0.0 1.7 1 1 1 2 2 2 0 CRISPR-associated exonuclease Csa1 Cas_Cas4 PF01930.17 ELR14010.1 - 0.031 14.4 0.2 0.09 12.9 0.2 1.9 1 1 0 1 1 1 0 Domain of unknown function DUF83 Med9 PF07544.13 ELR14010.1 - 0.1 12.7 0.0 0.27 11.4 0.0 1.7 2 0 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 Usp PF00582.26 ELR14011.1 - 4.9e-18 66.0 0.6 1.7e-17 64.3 0.6 1.8 1 1 0 1 1 1 1 Universal stress protein family ACC_central PF08326.12 ELR14011.1 - 0.11 10.7 0.2 0.14 10.4 0.2 1.0 1 0 0 1 1 1 0 Acetyl-CoA carboxylase, central region adh_short PF00106.25 ELR14013.1 - 4.9e-45 153.4 0.4 6.1e-45 153.1 0.4 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ELR14013.1 - 1.1e-27 97.1 0.2 1.4e-27 96.8 0.2 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ELR14013.1 - 2.5e-13 50.3 0.1 3.5e-13 49.9 0.1 1.2 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.6 ELR14013.1 - 2.6e-05 24.2 0.2 0.00011 22.1 0.2 1.9 1 1 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 ELR14013.1 - 3.6e-05 23.3 0.3 9.2e-05 22.0 0.3 1.7 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 ELR14013.1 - 0.0047 16.4 0.0 0.0068 15.8 0.0 1.3 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase NmrA PF05368.13 ELR14013.1 - 0.021 14.4 0.5 0.55 9.7 0.1 2.1 2 0 0 2 2 2 0 NmrA-like family 3HCDH_N PF02737.18 ELR14013.1 - 0.023 14.6 0.0 0.046 13.6 0.0 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Polysacc_synt_2 PF02719.15 ELR14013.1 - 0.027 13.6 0.0 0.044 12.9 0.0 1.4 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein ApbA PF02558.16 ELR14013.1 - 0.044 13.4 0.1 0.15 11.7 0.0 1.9 2 0 0 2 2 2 0 Ketopantoate reductase PanE/ApbA Glyco_transf_4 PF13439.6 ELR14013.1 - 0.067 13.2 0.0 2.2 8.3 0.0 2.3 2 0 0 2 2 2 0 Glycosyltransferase Family 4 RmlD_sub_bind PF04321.17 ELR14013.1 - 0.15 11.1 0.0 0.26 10.3 0.0 1.3 1 0 0 1 1 1 0 RmlD substrate binding domain POR PF01558.18 ELR14013.1 - 0.19 11.8 1.9 2.8 8.0 0.2 2.5 2 1 1 3 3 3 0 Pyruvate ferredoxin/flavodoxin oxidoreductase Peptidase_S10 PF00450.22 ELR14014.1 - 8.8e-120 400.9 0.2 1e-119 400.7 0.2 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase Tecti-min-caps PF09300.10 ELR14014.1 - 0.053 13.6 0.0 0.15 12.2 0.0 1.7 1 0 0 1 1 1 0 Tectiviridae, minor capsid Acetyltransf_1 PF00583.25 ELR14015.1 - 2.2e-11 44.0 0.1 4.3e-11 43.1 0.1 1.6 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family FR47 PF08445.10 ELR14015.1 - 1.1e-07 31.7 0.1 1.3e-06 28.3 0.0 2.2 2 0 0 2 2 2 1 FR47-like protein Acetyltransf_7 PF13508.7 ELR14015.1 - 1.9e-07 31.4 0.0 2.7e-07 30.9 0.0 1.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 ELR14015.1 - 1.7e-06 27.9 0.0 2.5e-06 27.5 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 ELR14015.1 - 7.8e-06 26.0 0.0 1.7e-05 24.9 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.7 ELR14015.1 - 6e-05 23.7 0.1 7.4e-05 23.4 0.1 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Complex1_LYR PF05347.15 ELR14016.1 - 0.00011 22.2 0.3 0.0004 20.4 0.0 2.0 2 0 0 2 2 2 1 Complex 1 protein (LYR family) DnaJ PF00226.31 ELR14016.1 - 0.008 16.3 1.2 0.019 15.1 0.4 1.9 2 0 0 2 2 2 1 DnaJ domain Caskin-Pro-rich PF16907.5 ELR14017.1 - 0.067 13.7 1.1 0.095 13.2 1.1 1.2 1 0 0 1 1 1 0 Proline rich region of Caskin proteins RRM_1 PF00076.22 ELR14018.1 - 7.6e-20 70.5 0.1 1e-19 70.1 0.1 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 ELR14018.1 - 0.00093 19.3 0.0 0.0012 18.9 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif Reticulon PF02453.17 ELR14019.1 - 1.6e-21 76.9 3.1 1.9e-21 76.6 3.1 1.1 1 0 0 1 1 1 1 Reticulon Phage_holin_8 PF16931.5 ELR14019.1 - 0.0019 18.2 0.5 0.0019 18.2 0.5 1.7 2 0 0 2 2 2 1 Putative phage holin Phage_holin_3_6 PF07332.11 ELR14019.1 - 0.1 12.6 5.7 0.54 10.3 0.5 2.1 2 0 0 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III Coa1 PF08695.10 ELR14020.1 - 0.23 11.2 0.7 0.9 9.3 0.1 2.4 2 0 0 2 2 2 0 Cytochrome oxidase complex assembly protein 1 DUF3398 PF11878.8 ELR14021.1 - 0.071 13.6 0.5 0.087 13.3 0.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3398) PI3K_1B_p101 PF10486.9 ELR14022.1 - 1.2e-11 43.2 0.9 1.3e-08 33.2 0.9 2.9 1 1 2 3 3 3 3 Phosphoinositide 3-kinase gamma adapter protein p101 subunit Pacs-1 PF10254.9 ELR14022.1 - 0.08 11.9 0.0 0.21 10.5 0.0 1.6 2 0 0 2 2 2 0 PACS-1 cytosolic sorting protein MT-A70 PF05063.14 ELR14023.1 - 8.3e-38 130.0 0.0 1.5e-37 129.2 0.0 1.4 2 0 0 2 2 2 1 MT-A70 Cons_hypoth95 PF03602.15 ELR14023.1 - 0.13 11.8 0.0 0.47 10.1 0.0 1.9 3 0 0 3 3 3 0 Conserved hypothetical protein 95 CDC27 PF09507.10 ELR14023.1 - 0.45 9.8 2.2 0.55 9.6 2.2 1.1 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 2OG-FeII_Oxy_2 PF13532.6 ELR14025.1 - 1.6e-12 48.0 0.0 3.3e-12 47.0 0.0 1.5 1 1 1 2 2 2 1 2OG-Fe(II) oxygenase superfamily Acetyltransf_3 PF13302.7 ELR14026.1 - 1.9e-16 61.0 0.0 2.4e-16 60.6 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.6 ELR14026.1 - 0.013 15.2 0.0 0.026 14.2 0.0 1.5 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 ELR14026.1 - 0.024 14.8 0.0 0.025 14.7 0.0 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 ELR14026.1 - 0.057 13.6 0.0 0.2 11.9 0.0 1.8 1 1 0 1 1 1 0 Acetyltransferase (GNAT) family SDF PF00375.18 ELR14027.1 - 2.5e-124 415.3 30.7 2.9e-124 415.0 30.7 1.0 1 0 0 1 1 1 1 Sodium:dicarboxylate symporter family GOLD_2 PF13897.6 ELR14028.1 - 2.1e-07 31.5 1.2 0.0047 17.4 0.4 2.5 1 1 1 2 2 2 2 Golgi-dynamics membrane-trafficking Response_reg PF00072.24 ELR14029.1 - 2e-25 89.1 0.6 3.7e-25 88.3 0.6 1.5 1 0 0 1 1 1 1 Response regulator receiver domain HATPase_c PF02518.26 ELR14029.1 - 1.2e-21 77.3 0.0 6.5e-21 74.9 0.0 2.2 1 1 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase GAF_2 PF13185.6 ELR14029.1 - 5.7e-15 55.8 0.0 1.3e-14 54.7 0.0 1.6 1 0 0 1 1 1 1 GAF domain HisKA PF00512.25 ELR14029.1 - 8.6e-10 38.5 0.2 2.2e-09 37.2 0.2 1.8 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain PAS_8 PF13188.7 ELR14029.1 - 1.9e-07 30.9 0.0 5.2e-07 29.5 0.0 1.8 1 0 0 1 1 1 1 PAS domain GAF PF01590.26 ELR14029.1 - 0.00053 20.6 0.0 0.0015 19.2 0.0 1.8 1 0 0 1 1 1 1 GAF domain PAS_7 PF12860.7 ELR14029.1 - 0.0047 17.1 0.0 0.014 15.5 0.0 1.8 1 0 0 1 1 1 1 PAS fold PAS_4 PF08448.10 ELR14029.1 - 0.0058 16.9 0.2 0.02 15.1 0.0 2.0 2 0 0 2 2 2 1 PAS fold PAS PF00989.25 ELR14029.1 - 0.008 16.2 0.0 0.024 14.6 0.0 1.9 1 0 0 1 1 1 1 PAS fold SLATT_2 PF18183.1 ELR14029.1 - 0.027 14.3 0.0 0.052 13.3 0.0 1.4 1 0 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain 2 PAS_9 PF13426.7 ELR14029.1 - 0.034 14.4 0.0 0.14 12.5 0.0 2.1 2 0 0 2 2 2 0 PAS domain THF_DHG_CYH_C PF02882.19 ELR14029.1 - 0.12 11.7 0.0 0.24 10.7 0.0 1.4 1 0 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain SSP160 PF06933.11 ELR14029.1 - 0.35 9.0 5.8 0.5 8.5 5.8 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 LepA_C PF06421.12 ELR14030.1 - 1.6e-41 140.8 2.3 2.5e-35 120.8 0.9 2.3 2 0 0 2 2 2 2 GTP-binding protein LepA C-terminus GTP_EFTU PF00009.27 ELR14030.1 - 1.1e-35 123.0 0.0 2e-35 122.1 0.0 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_C PF00679.24 ELR14030.1 - 1.1e-18 67.1 0.0 2.2e-18 66.0 0.0 1.6 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 ELR14030.1 - 2.7e-09 37.3 0.8 8.4e-09 35.7 0.1 2.2 2 0 0 2 2 2 1 Elongation factor Tu domain 2 EFG_II PF14492.6 ELR14030.1 - 0.00036 20.6 0.0 0.0013 18.7 0.0 1.9 1 1 0 1 1 1 1 Elongation Factor G, domain II SRPRB PF09439.10 ELR14030.1 - 0.0017 17.8 0.0 0.0032 16.9 0.0 1.4 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Ras PF00071.22 ELR14030.1 - 0.005 16.4 0.0 0.0083 15.7 0.0 1.3 1 0 0 1 1 1 1 Ras family RF3_C PF16658.5 ELR14030.1 - 0.0051 16.6 0.0 0.0092 15.8 0.0 1.4 1 0 0 1 1 1 1 Class II release factor RF3, C-terminal domain MMR_HSR1 PF01926.23 ELR14030.1 - 0.0085 16.2 0.0 0.019 15.0 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase UBA PF00627.31 ELR14030.1 - 0.065 13.2 0.0 0.19 11.6 0.0 1.8 1 0 0 1 1 1 0 UBA/TS-N domain CMV_1a PF12467.8 ELR14030.1 - 0.18 12.1 0.0 0.38 11.1 0.0 1.4 1 0 0 1 1 1 0 Cucumber mosaic virus 1a protein family Snurportin1 PF11538.8 ELR14030.1 - 0.5 10.6 1.8 1.1 9.5 1.8 1.5 1 0 0 1 1 1 0 Snurportin1 Fumerase_C PF05683.12 ELR14031.1 - 4.1e-91 303.9 0.0 6.7e-91 303.2 0.0 1.3 1 0 0 1 1 1 1 Fumarase C-terminus Fumerase PF05681.14 ELR14031.1 - 6.2e-89 298.0 0.0 8.1e-89 297.6 0.0 1.1 1 0 0 1 1 1 1 Fumarate hydratase (Fumerase) DUF1084 PF06454.11 ELR14032.1 - 2.1e-12 47.0 19.8 5.1e-12 45.8 19.8 1.5 1 1 0 1 1 1 1 Protein of unknown function (DUF1084) tRNA-synt_2b PF00587.25 ELR14033.1 - 8.3e-28 97.6 0.0 1.7e-27 96.6 0.0 1.5 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) Seryl_tRNA_N PF02403.22 ELR14033.1 - 1.7e-16 60.4 5.4 3.1e-16 59.5 5.4 1.4 1 0 0 1 1 1 1 Seryl-tRNA synthetase N-terminal domain FapA PF03961.13 ELR14033.1 - 0.025 13.2 0.7 0.035 12.7 0.7 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A APG6_N PF17675.1 ELR14033.1 - 0.026 15.0 3.8 0.048 14.2 3.8 1.4 1 0 0 1 1 1 0 Apg6 coiled-coil region ADIP PF11559.8 ELR14033.1 - 0.079 13.0 3.3 0.15 12.2 3.3 1.4 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding OmpH PF03938.14 ELR14033.1 - 0.11 12.9 2.6 0.19 12.0 2.6 1.3 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) DUF4140 PF13600.6 ELR14033.1 - 0.18 12.3 4.8 8.2 6.9 0.3 2.4 2 0 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) SOGA PF11365.8 ELR14033.1 - 0.22 12.7 2.7 0.59 11.3 2.7 1.7 1 0 0 1 1 1 0 Protein SOGA DUF4407 PF14362.6 ELR14033.1 - 0.43 9.9 2.1 0.5 9.7 1.2 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) Cnn_1N PF07989.11 ELR14033.1 - 2.5 8.3 8.1 17 5.7 0.5 3.1 3 0 0 3 3 3 0 Centrosomin N-terminal motif 1 DivIC PF04977.15 ELR14033.1 - 5 7.0 8.5 1.8 8.4 0.7 2.4 2 0 0 2 2 2 0 Septum formation initiator Spc24 PF08286.11 ELR14033.1 - 6.3 7.1 5.9 44 4.4 5.7 2.3 1 1 0 1 1 1 0 Spc24 subunit of Ndc80 Hexapep PF00132.24 ELR14034.1 - 3.4e-09 36.1 11.9 0.009 15.7 0.3 4.5 4 0 0 4 4 4 4 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 ELR14034.1 - 0.00092 18.9 7.7 0.19 11.5 1.7 2.8 2 0 0 2 2 2 2 Hexapeptide repeat of succinyl-transferase FapA PF03961.13 ELR14034.1 - 0.073 11.7 0.7 0.096 11.3 0.7 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A Spindle_Spc25 PF08234.12 ELR14035.1 - 2.9e-18 65.8 0.2 1.1e-17 64.0 0.0 2.0 2 0 0 2 2 2 1 Chromosome segregation protein Spc25 Spc7 PF08317.11 ELR14035.1 - 0.00047 19.1 23.5 0.00071 18.5 23.5 1.3 1 0 0 1 1 1 1 Spc7 kinetochore protein Filament PF00038.21 ELR14035.1 - 0.0046 16.6 25.2 0.032 13.8 27.0 1.4 2 0 0 2 2 2 1 Intermediate filament protein Nup88 PF10168.9 ELR14035.1 - 0.0088 13.9 23.7 0.01 13.7 23.7 1.0 1 0 0 1 1 1 1 Nuclear pore component Fez1 PF06818.15 ELR14035.1 - 0.099 13.1 28.3 0.3 11.5 25.9 2.0 1 1 1 2 2 2 0 Fez1 V_ATPase_I PF01496.19 ELR14035.1 - 0.15 10.0 13.7 0.18 9.7 13.7 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Peptidase_S46 PF10459.9 ELR14035.1 - 0.22 10.1 17.3 0.29 9.7 17.3 1.1 1 0 0 1 1 1 0 Peptidase S46 DIT1_PvcA PF05141.12 ELR14035.1 - 0.22 11.0 9.8 0.094 12.2 7.0 1.7 1 1 0 1 1 1 0 Pyoverdine/dityrosine biosynthesis protein Exonuc_VII_L PF02601.15 ELR14035.1 - 0.23 11.0 16.2 0.38 10.3 16.2 1.4 1 0 0 1 1 1 0 Exonuclease VII, large subunit FUSC PF04632.12 ELR14035.1 - 0.28 9.7 9.1 0.36 9.3 9.1 1.2 1 0 0 1 1 1 0 Fusaric acid resistance protein family DUF948 PF06103.11 ELR14035.1 - 0.32 11.3 11.2 0.35 11.1 2.2 2.7 2 1 1 3 3 2 0 Bacterial protein of unknown function (DUF948) Tho2 PF11262.8 ELR14035.1 - 0.35 10.0 16.7 0.18 11.0 14.5 1.5 1 1 1 2 2 2 0 Transcription factor/nuclear export subunit protein 2 Syntaxin-6_N PF09177.11 ELR14035.1 - 0.52 10.9 15.9 0.64 10.6 13.6 2.3 1 1 1 2 2 2 0 Syntaxin 6, N-terminal Cluap1 PF10234.9 ELR14035.1 - 0.75 9.1 22.3 3.5 7.0 22.3 2.0 1 1 0 1 1 1 0 Clusterin-associated protein-1 Golgin_A5 PF09787.9 ELR14035.1 - 0.91 8.9 29.7 1.6 8.2 29.6 1.4 1 1 0 1 1 1 0 Golgin subfamily A member 5 IFT57 PF10498.9 ELR14035.1 - 1.2 8.0 21.7 1.7 7.5 21.7 1.2 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 ADIP PF11559.8 ELR14035.1 - 1.3 9.1 29.5 7.2 6.7 20.1 2.1 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding AAA_13 PF13166.6 ELR14035.1 - 1.3 7.6 19.7 1.1 7.8 4.9 2.0 1 1 1 2 2 2 0 AAA domain FPP PF05911.11 ELR14035.1 - 1.4 7.0 22.5 1.7 6.7 22.5 1.0 1 0 0 1 1 1 0 Filament-like plant protein, long coiled-coil DUF4411 PF14367.6 ELR14035.1 - 1.5 8.7 10.7 0.12 12.3 4.2 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4411) Atg14 PF10186.9 ELR14035.1 - 1.5 7.8 23.8 2.2 7.3 23.7 1.3 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 CRIC_ras_sig PF10534.9 ELR14035.1 - 1.6 8.9 12.4 2.5 8.4 0.5 3.3 2 1 1 3 3 3 0 Connector enhancer of kinase suppressor of ras TMF_DNA_bd PF12329.8 ELR14035.1 - 2.3 8.3 28.3 0.38 10.8 4.2 3.6 1 1 2 3 3 3 0 TATA element modulatory factor 1 DNA binding APG6_N PF17675.1 ELR14035.1 - 2.6 8.6 31.8 88 3.6 31.8 2.3 1 1 0 1 1 1 0 Apg6 coiled-coil region DUF4413 PF14372.6 ELR14035.1 - 3 8.3 5.7 1e+02 3.4 0.0 2.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4413) Muted PF14942.6 ELR14035.1 - 3.3 8.1 24.0 5 7.4 21.8 2.2 1 1 1 2 2 2 0 Organelle biogenesis, Muted-like protein LMBR1 PF04791.16 ELR14035.1 - 3.3 6.5 11.1 5 5.9 11.1 1.3 1 0 0 1 1 1 0 LMBR1-like membrane protein DUF1664 PF07889.12 ELR14035.1 - 3.4 7.7 17.8 4.2 7.4 6.4 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) MutS_III PF05192.18 ELR14035.1 - 3.7 7.7 11.6 5.4 7.2 11.6 1.2 1 0 0 1 1 1 0 MutS domain III MPS2 PF17060.5 ELR14035.1 - 5 6.3 17.8 11 5.1 17.7 1.6 1 1 0 1 1 1 0 Monopolar spindle protein 2 OmpH PF03938.14 ELR14035.1 - 5.6 7.3 34.2 2.4 8.5 15.2 2.3 1 1 1 2 2 2 0 Outer membrane protein (OmpH-like) Gp-FAR-1 PF05823.12 ELR14035.1 - 5.7 7.3 13.7 2.9 8.2 8.5 2.4 2 1 1 3 3 2 0 Nematode fatty acid retinoid binding protein (Gp-FAR-1) Baculo_PEP_C PF04513.12 ELR14035.1 - 6 6.9 7.1 13 5.8 2.7 2.9 2 1 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus Lectin_N PF03954.14 ELR14035.1 - 7.1 6.4 14.5 0.71 9.6 3.6 2.4 1 1 1 2 2 2 0 Hepatic lectin, N-terminal domain DUF2115 PF09888.9 ELR14035.1 - 8.1 6.9 10.5 5.7 7.4 7.3 2.0 1 1 1 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2115) GBP_C PF02841.14 ELR14035.1 - 8.3 5.7 26.5 11 5.3 26.5 1.1 1 0 0 1 1 1 0 Guanylate-binding protein, C-terminal domain Sec34 PF04136.15 ELR14035.1 - 9.3 6.1 15.2 1.9 8.4 6.6 2.4 1 1 1 2 2 2 0 Sec34-like family DLP_helical PF18709.1 ELR14035.1 - 9.4 5.3 20.5 0.19 10.9 3.9 2.8 1 1 2 3 3 3 0 Dynamin-like helical domain DUF3450 PF11932.8 ELR14035.1 - 9.6 5.4 29.8 47 3.2 16.5 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF3450) Pkinase_Tyr PF07714.17 ELR14036.1 - 3.2e-61 206.9 0.0 4.8e-61 206.3 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ELR14036.1 - 1.6e-53 181.8 0.0 1.6e-53 181.8 0.0 1.8 2 0 0 2 2 2 1 Protein kinase domain Kdo PF06293.14 ELR14036.1 - 1.3e-05 24.6 0.0 2e-05 24.1 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 ELR14036.1 - 1.7e-05 24.9 0.0 3.7e-05 23.7 0.0 1.5 2 0 0 2 2 2 1 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 ELR14036.1 - 0.00021 20.2 0.0 0.00021 20.2 0.0 2.4 2 1 0 2 2 2 1 Fungal protein kinase Haspin_kinase PF12330.8 ELR14036.1 - 0.00088 18.3 0.1 0.00088 18.3 0.1 2.3 2 2 0 2 2 2 1 Haspin like kinase domain PPR_2 PF13041.6 ELR14037.1 - 3e-16 59.3 0.0 2.4e-05 24.4 0.0 5.6 6 0 0 6 6 6 3 PPR repeat family PPR PF01535.20 ELR14037.1 - 2.1e-15 55.8 1.3 0.024 14.9 0.0 7.2 8 0 0 8 8 8 3 PPR repeat PPR_3 PF13812.6 ELR14037.1 - 2.3e-08 34.0 0.0 1.4 9.1 0.1 5.9 4 1 2 6 6 6 2 Pentatricopeptide repeat domain PPR_long PF17177.4 ELR14037.1 - 8.5e-08 31.8 0.1 0.0012 18.2 0.0 3.5 3 0 0 3 3 3 1 Pentacotripeptide-repeat region of PRORP TPR_19 PF14559.6 ELR14037.1 - 9.9e-08 32.4 4.2 0.0012 19.4 0.0 4.9 4 1 1 5 5 4 1 Tetratricopeptide repeat PPR_1 PF12854.7 ELR14037.1 - 1.5e-06 27.8 0.0 0.0073 16.0 0.0 4.7 5 0 0 5 5 5 1 PPR repeat SPOB_a PF14689.6 ELR14037.1 - 3e-06 26.9 0.4 0.19 11.5 0.0 4.1 5 0 0 5 5 5 2 Sensor_kinase_SpoOB-type, alpha-helical domain TPR_14 PF13428.6 ELR14037.1 - 1.7e-05 25.2 10.1 5.1 8.2 0.2 6.6 6 1 1 7 7 6 2 Tetratricopeptide repeat CobW_C PF07683.14 ELR14037.1 - 0.001 18.9 0.0 0.032 14.2 0.0 3.0 2 0 0 2 2 2 1 Cobalamin synthesis protein cobW C-terminal domain ERAP1_C PF11838.8 ELR14037.1 - 0.002 17.8 6.6 0.003 17.2 0.2 2.4 2 1 0 2 2 2 1 ERAP1-like C-terminal domain TPR_6 PF13174.6 ELR14037.1 - 0.021 15.4 0.4 8.2 7.3 0.1 3.6 3 0 0 3 3 2 0 Tetratricopeptide repeat TPR_4 PF07721.14 ELR14037.1 - 0.072 13.7 0.2 0.072 13.7 0.2 5.0 5 0 0 5 5 4 0 Tetratricopeptide repeat Spt5_N PF11942.8 ELR14037.1 - 1.5 9.9 27.9 1.7 9.7 10.3 3.7 3 0 0 3 3 3 0 Spt5 transcription elongation factor, acidic N-terminal TPR_16 PF13432.6 ELR14037.1 - 1.5 9.5 11.0 14 6.4 1.6 4.0 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_7 PF13176.6 ELR14037.1 - 1.9 8.7 3.8 5.9 7.2 0.1 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat CENP-B_dimeris PF09026.10 ELR14037.1 - 7 7.1 18.9 9.7 6.7 0.6 2.8 2 0 0 2 2 2 0 Centromere protein B dimerisation domain NTF2 PF02136.20 ELR14038.1 - 1.1e-16 61.5 0.0 1.5e-16 61.1 0.0 1.2 1 0 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain DUF4440 PF14534.6 ELR14038.1 - 0.0083 16.5 0.0 0.014 15.8 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4440) Lipase_3 PF01764.25 ELR14039.1 - 1.3e-11 44.5 0.0 6.9e-11 42.2 0.0 2.1 1 1 0 1 1 1 1 Lipase (class 3) PHP PF02811.19 ELR14039.1 - 0.049 13.9 0.0 0.099 12.9 0.0 1.4 1 0 0 1 1 1 0 PHP domain Auxin_canalis PF05703.11 ELR14039.1 - 2.1 8.2 7.0 5.2 6.9 7.0 1.6 1 0 0 1 1 1 0 Auxin canalisation SAP30_Sin3_bdg PF13867.6 ELR14040.1 - 6.2e-11 42.5 0.8 1.9e-10 40.9 0.8 1.9 1 1 0 1 1 1 1 Sin3 binding region of histone deacetylase complex subunit SAP30 DUF2573 PF10835.8 ELR14040.1 - 0.00026 21.3 0.0 0.00044 20.5 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2573) DUF3106 PF11304.8 ELR14040.1 - 0.03 14.8 0.3 0.064 13.7 0.3 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3106) Nucleoporin_FG2 PF15967.5 ELR14042.1 - 6.9e-12 44.7 27.7 6.9e-12 44.7 27.7 2.4 1 1 1 2 2 2 1 Nucleoporin FG repeated region 4HB_MCP_1 PF12729.7 ELR14042.1 - 0.0066 16.0 0.8 0.015 14.9 0.8 1.7 1 1 0 1 1 1 1 Four helix bundle sensory module for signal transduction BLOC1_2 PF10046.9 ELR14042.1 - 0.063 13.6 5.7 0.4 11.0 0.4 2.3 2 0 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 SRP54_N PF02881.19 ELR14042.1 - 0.14 12.4 1.1 0.25 11.6 0.0 2.0 3 0 0 3 3 3 0 SRP54-type protein, helical bundle domain Laminin_II PF06009.12 ELR14042.1 - 0.5 10.4 4.7 1.4 8.9 0.7 2.2 2 0 0 2 2 2 0 Laminin Domain II PEP-utilisers_N PF05524.13 ELR14042.1 - 0.6 10.3 4.3 4.7 7.4 0.2 2.3 2 0 0 2 2 2 0 PEP-utilising enzyme, N-terminal DUF883 PF05957.13 ELR14042.1 - 1.5 9.5 8.8 3.7 8.2 0.3 2.6 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF883) THOC7 PF05615.13 ELR14042.1 - 1.6 9.0 9.8 4.1 7.7 4.8 2.2 2 0 0 2 2 2 0 Tho complex subunit 7 Ras PF00071.22 ELR14043.1 - 2.7e-51 173.4 0.1 3.1e-51 173.2 0.1 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR14043.1 - 3.3e-13 49.9 0.1 5.2e-13 49.3 0.1 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR14043.1 - 3.1e-09 36.5 0.1 3.6e-09 36.3 0.1 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 ELR14043.1 - 2.5e-05 24.3 0.1 0.0031 17.4 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase GTP_EFTU PF00009.27 ELR14043.1 - 0.0032 17.1 0.0 0.0066 16.0 0.0 1.4 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 ELR14043.1 - 0.0041 17.2 0.0 0.0074 16.4 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase Ras PF00071.22 ELR14044.1 - 6.7e-15 55.1 0.0 8.8e-14 51.4 0.0 2.0 2 0 0 2 2 2 1 Ras family Roc PF08477.13 ELR14044.1 - 7.4e-11 42.3 0.0 2.6e-10 40.6 0.0 1.8 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Gtr1_RagA PF04670.12 ELR14044.1 - 0.00027 20.4 0.0 0.00037 19.9 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Arf PF00025.21 ELR14044.1 - 0.0015 18.0 0.0 0.0027 17.2 0.0 1.4 1 0 0 1 1 1 1 ADP-ribosylation factor family Septin PF00735.18 ELR14044.1 - 0.0057 16.0 0.0 0.79 8.9 0.0 2.1 2 0 0 2 2 2 2 Septin MCM PF00493.23 ELR14044.1 - 0.014 14.5 0.0 0.023 13.8 0.0 1.3 1 0 0 1 1 1 0 MCM P-loop domain MMR_HSR1 PF01926.23 ELR14044.1 - 0.02 15.0 0.0 0.033 14.2 0.0 1.4 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_16 PF13191.6 ELR14044.1 - 0.12 12.7 0.0 0.21 11.9 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain Cation_efflux PF01545.21 ELR14045.1 - 1e-31 110.2 4.0 1.3e-31 109.9 4.0 1.1 1 0 0 1 1 1 1 Cation efflux family Lectin_N PF03954.14 ELR14046.1 - 0.0011 18.7 0.7 0.28 10.9 0.2 2.8 1 1 2 3 3 3 1 Hepatic lectin, N-terminal domain DivIC PF04977.15 ELR14046.1 - 0.0046 16.7 8.3 0.19 11.5 0.2 3.1 1 1 2 3 3 3 1 Septum formation initiator Baculo_PEP_C PF04513.12 ELR14046.1 - 0.0058 16.7 1.2 0.0058 16.7 1.2 1.9 1 1 1 2 2 2 1 Baculovirus polyhedron envelope protein, PEP, C terminus Filament PF00038.21 ELR14046.1 - 0.013 15.1 3.4 0.019 14.6 3.4 1.2 1 0 0 1 1 1 0 Intermediate filament protein TPR_MLP1_2 PF07926.12 ELR14046.1 - 0.014 15.5 5.7 0.26 11.3 0.5 2.1 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein DUF3584 PF12128.8 ELR14046.1 - 0.03 11.9 8.1 0.027 12.0 3.0 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF3584) YabA PF06156.13 ELR14046.1 - 0.033 14.8 0.8 2.4 8.8 0.0 2.3 1 1 1 2 2 2 0 Initiation control protein YabA TBCC_N PF16752.5 ELR14046.1 - 0.054 13.9 6.6 1.7 9.1 1.1 2.2 1 1 1 2 2 2 0 Tubulin-specific chaperone C N-terminal domain SOGA PF11365.8 ELR14046.1 - 0.084 14.0 0.6 12 7.1 0.1 2.2 2 0 0 2 2 2 0 Protein SOGA THOC7 PF05615.13 ELR14046.1 - 0.092 13.0 9.6 1.7 9.0 5.1 2.5 1 1 1 2 2 2 0 Tho complex subunit 7 ZapB PF06005.12 ELR14046.1 - 0.12 12.8 0.2 13 6.4 0.0 2.4 1 1 1 2 2 2 0 Cell division protein ZapB Spectrin PF00435.21 ELR14046.1 - 0.13 12.7 2.2 0.95 10.0 0.2 2.1 1 1 1 2 2 2 0 Spectrin repeat Fib_alpha PF08702.10 ELR14046.1 - 0.16 12.2 3.0 1.4 9.1 0.5 2.0 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family SPAM PF02090.15 ELR14046.1 - 0.18 11.6 1.5 2.1 8.1 0.5 1.9 1 1 1 2 2 2 0 Salmonella surface presentation of antigen gene type M protein OmpH PF03938.14 ELR14046.1 - 0.19 12.1 13.4 0.84 10.0 13.4 1.9 1 1 0 1 1 1 0 Outer membrane protein (OmpH-like) DUF724 PF05266.14 ELR14046.1 - 0.19 11.6 9.6 1.9 8.3 5.1 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF724) Fez1 PF06818.15 ELR14046.1 - 0.2 12.1 3.0 0.3 11.5 3.0 1.4 1 1 0 1 1 1 0 Fez1 JIP_LZII PF16471.5 ELR14046.1 - 0.23 11.6 1.8 4.4 7.6 0.2 2.4 1 1 1 2 2 2 0 JNK-interacting protein leucine zipper II DUF1664 PF07889.12 ELR14046.1 - 0.31 11.1 6.1 1.7 8.7 0.7 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) CCDC66 PF15236.6 ELR14046.1 - 0.34 10.7 8.5 2 8.3 1.5 2.1 1 1 1 2 2 2 0 Coiled-coil domain-containing protein 66 Atg14 PF10186.9 ELR14046.1 - 0.34 9.9 6.4 3 6.8 6.4 1.9 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF4472 PF14739.6 ELR14046.1 - 0.49 11.1 4.3 3.1 8.6 2.7 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4472) DUF4140 PF13600.6 ELR14046.1 - 0.79 10.2 8.5 69 4.0 8.5 2.3 1 1 0 1 1 1 0 N-terminal domain of unknown function (DUF4140) NRIP1_repr_3 PF15689.5 ELR14046.1 - 1.3 9.4 5.1 13 6.1 0.4 2.2 1 1 1 2 2 2 0 Nuclear receptor-interacting protein 1 repression 3 DUF730 PF05325.11 ELR14046.1 - 1.7 8.7 5.4 3.2 7.8 0.6 2.3 1 1 0 2 2 2 0 Protein of unknown function (DUF730) DUF4200 PF13863.6 ELR14046.1 - 1.8 9.0 9.2 3.3 8.1 9.2 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4200) Syntaxin PF00804.25 ELR14046.1 - 1.9 8.1 9.2 4 7.1 8.9 1.7 1 1 0 1 1 1 0 Syntaxin RCC1 PF00415.18 ELR14047.1 - 5e-72 238.4 15.6 1.2e-12 48.3 0.1 7.2 7 0 0 7 7 7 6 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 ELR14047.1 - 9.2e-29 98.6 24.9 3.3e-06 26.7 0.2 7.3 7 0 0 7 7 7 6 Regulator of chromosome condensation (RCC1) repeat DUF4213 PF13938.6 ELR14047.1 - 0.0049 17.1 0.9 12 6.2 0.1 4.2 3 1 1 4 4 4 2 Putative heavy-metal chelation SPASM PF13186.6 ELR14047.1 - 0.066 13.7 0.1 1.9 9.0 0.0 2.3 2 0 0 2 2 2 0 Iron-sulfur cluster-binding domain FGGY_N PF00370.21 ELR14048.1 - 3.2e-23 82.6 0.0 1.3e-17 64.2 0.0 3.1 2 1 0 2 2 2 2 FGGY family of carbohydrate kinases, N-terminal domain FGGY_C PF02782.16 ELR14048.1 - 3.6e-22 79.1 0.0 1.2e-21 77.4 0.0 2.0 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain Bac_DNA_binding PF00216.21 ELR14049.1 - 4.2e-13 49.3 0.2 1.5e-11 44.3 0.2 2.2 1 1 0 1 1 1 1 Bacterial DNA-binding protein YabA PF06156.13 ELR14050.1 - 0.0023 18.5 0.9 0.0023 18.5 0.9 9.8 2 1 4 7 7 7 1 Initiation control protein YabA ADIP PF11559.8 ELR14050.1 - 0.011 15.8 3.0 0.011 15.8 3.0 10.3 4 1 5 11 11 11 0 Afadin- and alpha -actinin-Binding PH PF00169.29 ELR14051.1 - 3.1e-11 43.7 0.8 4.9e-10 39.9 0.1 3.0 3 1 0 3 3 3 1 PH domain zf-C3HC4_3 PF13920.6 ELR14051.1 - 4.4e-10 39.3 8.6 6.8e-10 38.7 8.6 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) K-box PF01486.17 ELR14051.1 - 6.6e-05 23.0 4.7 0.0002 21.4 4.7 1.8 1 0 0 1 1 1 1 K-box region PH_11 PF15413.6 ELR14051.1 - 0.0052 17.2 0.8 1.4 9.4 0.1 2.9 2 0 0 2 2 2 1 Pleckstrin homology domain Prok-RING_4 PF14447.6 ELR14051.1 - 0.0052 16.6 8.5 0.01 15.7 8.5 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 PDDEXK_9 PF08011.11 ELR14051.1 - 0.013 15.4 0.7 0.73 9.8 0.7 2.7 1 1 0 1 1 1 0 PD-(D/E)XK nuclease superfamily zf-RING_5 PF14634.6 ELR14051.1 - 0.013 15.4 9.6 0.023 14.7 9.6 1.4 1 0 0 1 1 1 0 zinc-RING finger domain PH_8 PF15409.6 ELR14051.1 - 0.021 15.1 0.0 5.3 7.4 0.0 2.5 2 0 0 2 2 2 0 Pleckstrin homology domain PH_3 PF14593.6 ELR14051.1 - 0.042 14.0 0.0 0.12 12.5 0.0 1.7 1 0 0 1 1 1 0 PH domain zf-RING_2 PF13639.6 ELR14051.1 - 0.4 11.1 9.2 0.75 10.2 9.2 1.4 1 0 0 1 1 1 0 Ring finger domain Cnd1_N PF12922.7 ELR14051.1 - 1 9.2 3.3 0.55 10.1 0.4 2.0 1 1 1 2 2 2 0 non-SMC mitotic condensation complex subunit 1, N-term MAP7 PF05672.11 ELR14051.1 - 2 8.1 35.5 0.028 14.1 25.1 2.5 2 0 0 2 2 2 0 MAP7 (E-MAP-115) family Mito_carr PF00153.27 ELR14052.1 - 7.6e-66 218.1 3.1 1.1e-22 79.8 0.2 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein FMN_red PF03358.15 ELR14053.1 - 1.2e-10 41.4 0.0 1.6e-10 40.9 0.0 1.2 1 0 0 1 1 1 1 NADPH-dependent FMN reductase Flavodoxin_2 PF02525.17 ELR14053.1 - 2.4e-07 30.6 0.0 3.1e-07 30.3 0.0 1.2 1 0 0 1 1 1 1 Flavodoxin-like fold Flavodoxin_5 PF12724.7 ELR14053.1 - 2.7e-05 24.5 0.1 0.0037 17.5 0.0 2.2 1 1 1 2 2 2 2 Flavodoxin domain Flavodoxin_1 PF00258.25 ELR14053.1 - 0.0006 20.0 0.1 0.00089 19.5 0.1 1.3 1 0 0 1 1 1 1 Flavodoxin Exo_endo_phos PF03372.23 ELR14054.1 - 3.7e-23 82.3 0.0 2.7e-22 79.5 0.0 2.0 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Kinesin PF00225.23 ELR14055.1 - 4.3e-80 269.1 0.1 3.1e-43 148.0 0.0 2.8 1 1 1 2 2 2 2 Kinesin motor domain Microtub_bd PF16796.5 ELR14055.1 - 7.3e-27 94.1 0.0 2.4e-26 92.4 0.0 2.0 1 0 0 1 1 1 1 Microtubule binding PH PF00169.29 ELR14055.1 - 1e-21 77.4 0.1 2.5e-21 76.1 0.1 1.7 1 0 0 1 1 1 1 PH domain PH_3 PF14593.6 ELR14055.1 - 6.1e-08 32.7 0.0 1.9e-07 31.2 0.0 1.8 1 0 0 1 1 1 1 PH domain PH_11 PF15413.6 ELR14055.1 - 1e-06 29.1 4.5 2e-05 24.9 4.5 2.7 1 1 0 1 1 1 1 Pleckstrin homology domain PH_9 PF15410.6 ELR14055.1 - 2.1e-05 24.8 0.6 0.00029 21.2 0.5 2.6 1 1 0 1 1 1 1 Pleckstrin homology domain PH_8 PF15409.6 ELR14055.1 - 0.0002 21.6 0.1 0.00051 20.3 0.1 1.7 1 0 0 1 1 1 1 Pleckstrin homology domain ATG16 PF08614.11 ELR14055.1 - 0.0017 18.6 3.0 0.0017 18.6 3.0 4.6 4 1 1 5 5 5 1 Autophagy protein 16 (ATG16) TMF_DNA_bd PF12329.8 ELR14055.1 - 0.0022 18.0 10.3 0.0022 18.0 10.3 6.0 4 1 1 6 6 6 1 TATA element modulatory factor 1 DNA binding SlyX PF04102.12 ELR14055.1 - 1.6 9.4 0.0 1.6 9.4 0.0 5.2 4 2 1 5 5 5 0 SlyX Peptidase_M18 PF02127.15 ELR14056.1 - 5.7e-27 94.6 0.1 6.9e-27 94.3 0.1 1.1 1 0 0 1 1 1 1 Aminopeptidase I zinc metalloprotease (M18) Peptidase_M18 PF02127.15 ELR14057.1 - 1.6e-129 432.5 0.0 1.8e-129 432.4 0.0 1.0 1 0 0 1 1 1 1 Aminopeptidase I zinc metalloprotease (M18) Peptidase_M42 PF05343.14 ELR14057.1 - 2.4e-10 39.9 0.0 6.9e-09 35.1 0.0 2.0 2 0 0 2 2 2 2 M42 glutamyl aminopeptidase DNA_topoisoIV PF00521.20 ELR14059.1 - 2.5e-124 415.5 0.1 4.1e-124 414.7 0.1 1.4 1 0 0 1 1 1 1 DNA gyrase/topoisomerase IV, subunit A TOPRIM_C PF16898.5 ELR14059.1 - 1.3e-53 180.6 3.3 4.7e-53 178.9 3.3 2.1 1 0 0 1 1 1 1 C-terminal associated domain of TOPRIM DNA_gyraseB PF00204.25 ELR14059.1 - 2.1e-25 89.2 6.0 2.8e-25 88.8 3.4 2.3 2 0 0 2 2 2 1 DNA gyrase B HATPase_c PF02518.26 ELR14059.1 - 3.6e-13 50.0 0.0 9.2e-13 48.7 0.0 1.8 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Toprim PF01751.22 ELR14059.1 - 3.1e-06 27.3 0.0 1.3e-05 25.3 0.0 2.2 1 0 0 1 1 1 1 Toprim domain EF-hand_1 PF00036.32 ELR14060.1 - 6.4e-42 138.0 13.3 7.2e-10 37.7 0.2 4.1 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 ELR14060.1 - 1.1e-35 121.9 3.5 4.6e-18 65.4 0.8 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 ELR14060.1 - 1.1e-31 106.1 7.1 1.6e-09 36.9 0.2 4.5 4 1 1 5 5 5 4 EF-hand domain EF-hand_8 PF13833.6 ELR14060.1 - 5.5e-30 103.0 12.1 2.9e-14 52.6 0.5 4.0 1 1 3 4 4 4 4 EF-hand domain pair EF-hand_5 PF13202.6 ELR14060.1 - 7.2e-27 91.7 9.1 3.5e-07 29.4 0.3 4.2 4 0 0 4 4 4 4 EF hand EF-hand_9 PF14658.6 ELR14060.1 - 3.8e-14 52.8 0.3 3.6e-07 30.4 0.0 2.1 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.7 ELR14060.1 - 1.9e-10 40.6 0.6 9.7e-05 22.3 0.1 2.2 1 1 1 2 2 2 2 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 ELR14060.1 - 9.9e-08 32.3 0.0 0.0025 18.1 0.0 2.1 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_11 PF08976.11 ELR14060.1 - 9.2e-06 26.5 0.0 6.9e-05 23.7 0.0 1.9 1 1 1 2 2 2 1 EF-hand domain Dockerin_1 PF00404.18 ELR14060.1 - 3.4e-05 24.0 4.8 0.068 13.4 0.4 3.3 1 1 3 4 4 4 2 Dockerin type I domain UPF0154 PF03672.13 ELR14060.1 - 0.00013 21.9 0.0 0.5 10.4 0.0 2.9 3 0 0 3 3 3 2 Uncharacterised protein family (UPF0154) TerB PF05099.13 ELR14060.1 - 0.00053 20.0 0.2 0.91 9.5 0.0 2.3 1 1 1 2 2 2 2 Tellurite resistance protein TerB Caleosin PF05042.13 ELR14060.1 - 0.0014 18.6 0.1 0.4 10.6 0.0 3.0 1 1 3 4 4 4 1 Caleosin related protein DUF1103 PF06513.11 ELR14060.1 - 0.0026 17.4 4.3 0.0038 16.9 4.3 1.3 1 1 0 1 1 1 1 Repeat of unknown function (DUF1103) Poly_export PF02563.16 ELR14060.1 - 0.0031 17.7 0.0 0.16 12.2 0.0 2.9 1 1 2 3 3 3 1 Polysaccharide biosynthesis/export protein EF-hand_14 PF17959.1 ELR14060.1 - 0.0034 17.7 0.1 4.4 7.7 0.0 2.4 2 1 0 2 2 2 2 EF-hand domain DUF4497 PF14924.6 ELR14060.1 - 0.0048 17.3 0.0 0.4 11.2 0.0 2.2 1 1 1 2 2 2 1 Protein of unknown function (DUF4497) DUF5580 PF17743.1 ELR14060.1 - 0.018 13.6 0.0 0.018 13.6 0.0 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5580) SurA_N_2 PF13623.6 ELR14060.1 - 0.037 13.9 0.5 1.9 8.3 0.1 2.3 1 1 1 2 2 2 0 SurA N-terminal domain DUF1296 PF06972.11 ELR14060.1 - 0.064 13.4 1.2 25 5.1 0.3 3.0 2 1 1 3 3 3 0 Protein of unknown function (DUF1296) RNA_pol_Rpb4 PF03874.16 ELR14060.1 - 0.091 13.1 0.6 1.6 9.0 0.2 2.4 2 0 0 2 2 2 0 RNA polymerase Rpb4 EFhand_Ca_insen PF08726.10 ELR14060.1 - 0.13 12.3 1.0 0.37 10.9 0.1 2.2 2 2 0 2 2 2 0 Ca2+ insensitive EF hand HAGH_C PF16123.5 ELR14062.1 - 4.5e-28 97.6 0.1 6.7e-28 97.0 0.1 1.3 1 0 0 1 1 1 1 Hydroxyacylglutathione hydrolase C-terminus Lactamase_B PF00753.27 ELR14062.1 - 3.5e-07 30.4 3.1 7.1e-07 29.4 3.1 1.5 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 ELR14062.1 - 0.00054 19.5 0.2 0.00094 18.7 0.2 1.6 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 ELR14062.1 - 0.12 12.3 0.6 0.31 10.9 0.6 1.7 1 1 0 1 1 1 0 Beta-lactamase superfamily domain KH_1 PF00013.29 ELR14063.1 - 5.8e-06 26.0 0.0 1.8e-05 24.4 0.0 1.9 2 0 0 2 2 2 1 KH domain KH_2 PF07650.17 ELR14063.1 - 0.049 13.5 0.0 0.1 12.4 0.0 1.5 1 0 0 1 1 1 0 KH domain RRM_1 PF00076.22 ELR14064.1 - 2.1e-13 49.9 0.0 2.9e-13 49.4 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-CCHC PF00098.23 ELR14064.1 - 1.2e-08 34.7 2.5 2e-08 33.9 2.5 1.4 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_5 PF14787.6 ELR14064.1 - 0.00016 21.3 1.8 0.00038 20.1 1.8 1.7 1 0 0 1 1 1 1 GAG-polyprotein viral zinc-finger zf-CCHC_2 PF13696.6 ELR14064.1 - 0.0008 19.2 1.3 0.0014 18.4 1.3 1.4 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_3 PF13917.6 ELR14064.1 - 0.0011 18.9 0.3 0.0011 18.9 0.3 1.7 2 0 0 2 2 2 1 Zinc knuckle RRM_5 PF13893.6 ELR14064.1 - 0.057 13.0 0.0 0.081 12.5 0.0 1.2 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SPRY PF00622.28 ELR14065.1 - 3.4e-19 69.1 0.2 5.8e-12 45.8 0.1 2.5 2 0 0 2 2 2 2 SPRY domain zf-C3HC4_3 PF13920.6 ELR14065.1 - 1.6e-09 37.5 7.8 2.9e-09 36.7 7.8 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Ufd2P_core PF10408.9 ELR14065.1 - 1.9e-06 26.8 5.2 2e-05 23.4 0.4 2.3 2 0 0 2 2 2 2 Ubiquitin elongating factor core zf-C3HC4_2 PF13923.6 ELR14065.1 - 0.00014 21.6 12.4 0.00031 20.5 12.4 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 ELR14065.1 - 0.00037 20.3 13.1 0.00085 19.1 13.1 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 ELR14065.1 - 0.00059 20.1 11.7 0.00059 20.1 11.7 2.0 2 0 0 2 2 2 1 Ring finger domain zf-RING_5 PF14634.6 ELR14065.1 - 0.0006 19.7 8.5 0.0015 18.5 8.5 1.7 1 0 0 1 1 1 1 zinc-RING finger domain Prok-RING_4 PF14447.6 ELR14065.1 - 0.019 14.8 8.5 0.043 13.7 8.5 1.6 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 Myc_N PF01056.18 ELR14065.1 - 0.1 12.5 3.2 0.27 11.1 3.2 1.6 1 0 0 1 1 1 0 Myc amino-terminal region zf-C3HC4_4 PF15227.6 ELR14065.1 - 0.28 11.4 9.9 0.71 10.1 9.9 1.7 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.6 ELR14065.1 - 3.7 7.6 17.2 0.77 9.8 11.6 2.4 2 0 0 2 2 2 0 RING-type zinc-finger Rft-1 PF04506.13 ELR14066.1 - 1.3e-20 73.7 0.1 1.4e-20 73.5 0.1 1.0 1 0 0 1 1 1 1 Rft protein Phage_holin_3_6 PF07332.11 ELR14066.1 - 0.011 15.7 0.8 2.5 8.2 0.0 2.1 2 0 0 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III DUF4191 PF13829.6 ELR14066.1 - 0.075 12.4 1.2 0.12 11.7 1.2 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4191) Polysacc_synt PF01943.17 ELR14066.1 - 0.1 12.0 4.8 0.22 10.9 4.5 1.6 2 0 0 2 2 2 0 Polysaccharide biosynthesis protein Lipase_3 PF01764.25 ELR14067.1 - 1.3e-23 83.5 0.0 1.8e-23 83.0 0.0 1.2 1 0 0 1 1 1 1 Lipase (class 3) Abhydrolase_6 PF12697.7 ELR14067.1 - 0.024 15.3 5.9 0.037 14.6 5.9 1.4 1 1 0 1 1 1 0 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 ELR14067.1 - 0.03 13.6 0.1 0.043 13.1 0.1 1.2 1 0 0 1 1 1 0 Serine aminopeptidase, S33 DUF2974 PF11187.8 ELR14067.1 - 0.046 13.3 0.1 0.15 11.6 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2974) Pkinase_Tyr PF07714.17 ELR14068.1 - 2.8e-52 177.6 0.0 3.5e-52 177.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ELR14068.1 - 1.3e-45 155.8 0.0 3.1e-44 151.3 0.0 2.0 1 1 0 1 1 1 1 Protein kinase domain SH2 PF00017.24 ELR14068.1 - 2.9e-11 43.3 0.0 6.7e-11 42.1 0.0 1.6 1 0 0 1 1 1 1 SH2 domain Pkinase_fungal PF17667.1 ELR14068.1 - 2.4e-05 23.3 0.0 3.3e-05 22.8 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 ELR14068.1 - 0.045 13.7 2.3 0.081 12.8 0.0 2.4 3 1 0 3 3 3 0 Phosphotransferase enzyme family Haspin_kinase PF12330.8 ELR14068.1 - 0.19 10.6 0.0 0.43 9.5 0.0 1.5 2 0 0 2 2 2 0 Haspin like kinase domain Pkinase PF00069.25 ELR14069.1 - 3.4e-56 190.6 0.0 6e-55 186.4 0.0 2.3 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR14069.1 - 4.8e-39 134.2 0.0 5.4e-38 130.7 0.0 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase KIND PF16474.5 ELR14069.1 - 0.0065 16.4 0.0 0.024 14.5 0.0 2.0 2 0 0 2 2 2 1 Kinase non-catalytic C-lobe domain Pkinase_fungal PF17667.1 ELR14069.1 - 0.016 14.0 0.2 2.6 6.7 0.0 2.4 1 1 1 2 2 2 0 Fungal protein kinase ABC1 PF03109.16 ELR14069.1 - 0.016 15.3 0.0 0.043 14.0 0.0 1.7 1 0 0 1 1 1 0 ABC1 family Abi_2 PF07751.11 ELR14069.1 - 0.034 14.4 0.5 0.11 12.8 0.0 1.9 2 1 0 2 2 2 0 Abi-like protein tRNA-synt_1b PF00579.25 ELR14070.1 - 5.5e-54 183.5 0.0 1.6e-34 119.5 0.0 2.1 1 1 1 2 2 2 2 tRNA synthetases class I (W and Y) Kelch_4 PF13418.6 ELR14071.1 - 2e-27 94.9 11.5 0.00011 22.2 0.0 7.3 7 0 0 7 7 7 6 Galactose oxidase, central domain BTB PF00651.31 ELR14071.1 - 1.2e-22 80.2 0.0 8e-14 51.8 0.0 2.9 2 1 1 3 3 3 2 BTB/POZ domain Kelch_5 PF13854.6 ELR14071.1 - 1.6e-22 79.0 4.0 0.00073 19.5 0.0 6.3 6 0 0 6 6 6 5 Kelch motif Kelch_6 PF13964.6 ELR14071.1 - 2.7e-19 68.7 3.5 0.00038 20.6 0.0 6.6 5 1 1 6 6 6 6 Kelch motif Kelch_3 PF13415.6 ELR14071.1 - 2.5e-18 65.9 17.6 5.3e-06 26.6 0.1 7.3 6 1 0 6 6 6 4 Galactose oxidase, central domain Kelch_1 PF01344.25 ELR14071.1 - 4.8e-18 64.5 3.4 0.00055 19.5 0.0 6.0 6 0 0 6 6 6 4 Kelch motif Kelch_2 PF07646.15 ELR14071.1 - 5.8e-17 60.9 4.4 0.0031 17.4 0.1 6.4 6 0 0 6 6 6 4 Kelch motif RAG2 PF03089.14 ELR14071.1 - 0.0077 15.3 0.0 0.49 9.3 0.0 3.1 3 0 0 3 3 3 1 Recombination activating protein 2 F-box-like PF12937.7 ELR14072.1 - 1 9.3 4.5 1.7 8.6 1.4 2.8 2 0 0 2 2 2 0 F-box-like Pkinase_Tyr PF07714.17 ELR14073.1 - 1.2e-121 404.9 0.0 3.1e-62 210.2 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 ELR14073.1 - 5.8e-108 360.2 0.0 8.9e-56 189.2 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain 5_nucleotid_C PF02872.18 ELR14073.1 - 8.1e-27 94.4 0.0 1.4e-26 93.6 0.0 1.3 1 0 0 1 1 1 1 5'-nucleotidase, C-terminal domain Haspin_kinase PF12330.8 ELR14073.1 - 2.2e-06 26.9 0.1 0.015 14.2 0.0 3.6 4 0 0 4 4 4 2 Haspin like kinase domain APH PF01636.23 ELR14073.1 - 5.7e-06 26.4 3.6 0.00067 19.6 0.1 3.4 3 1 1 4 4 4 2 Phosphotransferase enzyme family ABC1 PF03109.16 ELR14073.1 - 0.00023 21.3 0.0 0.014 15.5 0.0 2.7 2 0 0 2 2 2 1 ABC1 family Kinase-like PF14531.6 ELR14073.1 - 0.00097 18.5 0.0 0.067 12.5 0.0 2.3 2 0 0 2 2 2 1 Kinase-like EGF_2 PF07974.13 ELR14073.1 - 0.0047 17.3 7.1 0.01 16.2 7.1 1.6 1 0 0 1 1 1 1 EGF-like domain Pkinase_fungal PF17667.1 ELR14073.1 - 0.011 14.5 0.1 2.1 7.0 0.0 2.1 2 0 0 2 2 2 0 Fungal protein kinase RIO1 PF01163.22 ELR14073.1 - 0.013 15.1 0.1 2 8.0 0.0 2.4 2 0 0 2 2 2 0 RIO1 family Syndecan PF01034.20 ELR14073.1 - 0.046 13.6 1.9 0.11 12.4 1.9 1.6 1 0 0 1 1 1 0 Syndecan domain EB PF01683.18 ELR14073.1 - 1.3 9.4 7.0 0.5 10.7 3.0 2.2 2 0 0 2 2 2 0 EB module UPF0020 PF01170.18 ELR14076.1 - 1.3e-07 31.5 0.1 2e-05 24.3 0.1 2.6 1 1 0 1 1 1 1 Putative RNA methylase family UPF0020 N6_N4_Mtase PF01555.18 ELR14076.1 - 0.00099 18.9 0.2 0.029 14.1 0.0 2.7 3 0 0 3 3 3 1 DNA methylase N6_Mtase PF02384.16 ELR14076.1 - 0.13 11.5 0.0 0.2 10.9 0.0 1.2 1 0 0 1 1 1 0 N-6 DNA Methylase Thioredox_DsbH PF03190.15 ELR14077.1 - 2.1e-54 183.9 0.1 3.2e-36 124.8 0.0 2.5 1 1 1 2 2 2 2 Protein of unknown function, DUF255 Prefoldin_2 PF01920.20 ELR14077.1 - 2.4e-06 27.5 10.2 0.0061 16.5 0.7 3.3 4 0 0 4 4 4 2 Prefoldin subunit C5-epim_C PF06662.13 ELR14077.1 - 0.0012 18.4 0.4 1.8 8.0 0.1 2.5 2 0 0 2 2 2 2 D-glucuronyl C5-epimerase C-terminus Glyco_hydro_88 PF07470.13 ELR14077.1 - 0.0044 16.2 0.6 2.8 6.9 0.0 3.2 2 1 1 3 3 3 2 Glycosyl Hydrolase Family 88 MTBP_mid PF14919.6 ELR14077.1 - 0.0093 15.2 0.1 2.5 7.2 0.1 2.3 1 1 1 2 2 2 2 MDM2-binding Thioredoxin_7 PF13899.6 ELR14077.1 - 0.027 14.7 0.1 0.88 9.8 0.0 2.9 1 1 1 2 2 2 0 Thioredoxin-like Rotamase PF00639.21 ELR14077.1 - 0.89 10.5 3.4 13 6.8 0.5 2.9 2 0 0 2 2 2 0 PPIC-type PPIASE domain RhoGEF PF00621.20 ELR14078.1 - 2.3e-31 109.5 11.1 2.3e-31 109.5 11.1 2.3 2 1 0 2 2 2 1 RhoGEF domain PH PF00169.29 ELR14078.1 - 0.039 14.4 0.0 0.13 12.7 0.0 1.8 1 0 0 1 1 1 0 PH domain TPR_1 PF00515.28 ELR14079.1 - 1.5e-06 27.8 1.5 0.011 15.6 0.2 2.5 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.17 ELR14079.1 - 1.5e-05 24.8 3.3 0.057 13.5 0.3 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.6 ELR14079.1 - 1.9e-05 24.5 0.2 0.43 10.9 0.0 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_16 PF13432.6 ELR14079.1 - 4.6e-05 24.0 2.3 4.6e-05 24.0 2.3 1.7 2 0 0 2 2 1 1 Tetratricopeptide repeat TPR_19 PF14559.6 ELR14079.1 - 0.0001 22.8 1.4 0.00023 21.6 1.4 1.6 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_17 PF13431.6 ELR14079.1 - 0.0019 18.4 0.3 0.024 15.0 0.0 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.6 ELR14079.1 - 0.0023 18.2 7.3 0.0026 18.0 3.2 3.0 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_11 PF13414.6 ELR14079.1 - 0.0027 17.3 2.3 0.0049 16.5 0.2 2.3 1 1 1 2 2 2 1 TPR repeat TPR_10 PF13374.6 ELR14079.1 - 0.013 15.4 7.3 0.34 10.8 0.6 3.0 2 1 0 2 2 2 0 Tetratricopeptide repeat SHNi-TPR PF10516.9 ELR14079.1 - 0.033 13.6 2.2 0.097 12.1 0.2 2.2 2 0 0 2 2 2 0 SHNi-TPR TPR_20 PF14561.6 ELR14079.1 - 0.062 13.6 0.2 0.13 12.6 0.2 1.5 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_14 PF13428.6 ELR14079.1 - 0.081 13.8 8.5 0.22 12.4 0.4 3.8 3 1 1 4 4 4 0 Tetratricopeptide repeat DUF3384 PF11864.8 ELR14079.1 - 0.22 10.3 0.1 0.3 9.9 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3384) TPR_4 PF07721.14 ELR14079.1 - 0.43 11.3 4.0 0.57 11.0 0.2 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat Glycos_transf_2 PF00535.26 ELR14080.1 - 4.9e-05 23.2 0.0 9.5e-05 22.3 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 2 DAGAT PF03982.13 ELR14082.1 - 5.2e-10 38.7 0.0 7.3e-10 38.2 0.0 1.2 1 0 0 1 1 1 1 Diacylglycerol acyltransferase Acyltransferase PF01553.21 ELR14082.1 - 8.4e-10 38.4 0.0 1.4e-09 37.7 0.0 1.3 1 0 0 1 1 1 1 Acyltransferase zf-CCCH PF00642.24 ELR14083.1 - 2e-22 78.6 17.9 1.1e-07 31.6 2.2 3.8 4 0 0 4 4 4 3 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 ELR14083.1 - 7.9e-18 63.9 26.7 1.2e-06 28.3 1.7 4.0 4 0 0 4 4 4 3 Zinc finger domain Torus PF16131.5 ELR14083.1 - 3.6e-09 37.3 15.8 0.00087 20.0 0.2 4.0 3 1 2 5 5 5 3 Torus domain zf-CCCH_4 PF18044.1 ELR14083.1 - 2.2e-08 33.7 25.5 0.00023 20.8 2.0 3.8 4 0 0 4 4 4 3 CCCH-type zinc finger zf-CCCH_2 PF14608.6 ELR14083.1 - 2.4e-06 27.8 19.0 0.014 15.8 0.8 3.9 4 0 0 4 4 4 3 RNA-binding, Nab2-type zinc finger YabA PF06156.13 ELR14083.1 - 0.019 15.6 2.1 0.029 15.0 2.1 1.3 1 0 0 1 1 1 0 Initiation control protein YabA zf-CCCH_3 PF15663.5 ELR14083.1 - 0.032 14.5 8.2 0.033 14.4 2.5 2.6 1 1 1 2 2 2 0 Zinc-finger containing family Rootletin PF15035.6 ELR14083.1 - 0.043 13.8 3.5 0.062 13.3 3.5 1.2 1 0 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion Defensin_int PF17858.1 ELR14083.1 - 0.17 11.9 15.8 0.81 9.7 0.9 3.3 3 0 0 3 3 3 0 Platypus intermediate defensin-like peptide Importin_rep_6 PF18829.1 ELR14083.1 - 0.33 11.1 4.7 0.52 10.5 4.7 1.3 1 0 0 1 1 1 0 Importin repeat 6 NRBF2 PF08961.10 ELR14083.1 - 0.46 10.1 7.8 0.69 9.5 7.8 1.2 1 0 0 1 1 1 0 Nuclear receptor-binding factor 2, autophagy regulator DUF2623 PF11115.8 ELR14083.1 - 0.47 10.6 4.7 2.4 8.3 1.1 2.7 1 1 1 2 2 2 0 Protein of unknown function (DUF2623) Slu7 PF11708.8 ELR14083.1 - 2.4 7.9 9.2 3.2 7.4 9.2 1.1 1 0 0 1 1 1 0 Pre-mRNA splicing Prp18-interacting factor MIF4G PF02854.19 ELR14085.1 - 1.5e-39 135.9 0.0 1.9e-39 135.5 0.0 1.1 1 0 0 1 1 1 1 MIF4G domain Profilin PF00235.19 ELR14085.1 - 2.4e-28 98.9 0.0 4.4e-28 98.1 0.0 1.3 1 0 0 1 1 1 1 Profilin Acetyltransf_1 PF00583.25 ELR14085.1 - 1.9e-10 41.0 0.1 7.3e-10 39.1 0.1 2.0 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 ELR14085.1 - 5.3e-06 26.4 0.0 1.1e-05 25.4 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 ELR14085.1 - 3.1e-05 24.3 0.0 9.4e-05 22.8 0.0 1.8 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 ELR14085.1 - 0.00027 21.0 0.0 0.0006 19.9 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 ELR14085.1 - 0.00056 19.8 0.0 0.002 18.0 0.0 1.9 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_3 PF13302.7 ELR14085.1 - 0.00087 20.0 0.1 0.0021 18.8 0.1 1.7 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain eIF_4G1 PF12152.8 ELR14085.1 - 0.0067 16.6 0.0 0.014 15.6 0.0 1.5 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 4G1 Acetyltransf_CG PF14542.6 ELR14085.1 - 0.012 15.7 0.0 0.03 14.4 0.0 1.6 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase Acetyltransf_8 PF13523.6 ELR14085.1 - 0.022 14.5 0.1 0.061 13.0 0.0 1.8 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain Robl_LC7 PF03259.17 ELR14085.1 - 0.18 11.6 0.0 0.44 10.3 0.0 1.6 1 0 0 1 1 1 0 Roadblock/LC7 domain TALPID3 PF15324.6 ELR14085.1 - 4.1 4.9 5.1 5.8 4.5 5.1 1.1 1 0 0 1 1 1 0 Hedgehog signalling target RhoGEF PF00621.20 ELR14086.1 - 1e-51 175.8 1.1 3.5e-51 174.0 1.1 2.0 1 0 0 1 1 1 1 RhoGEF domain PH PF00169.29 ELR14086.1 - 3.1e-12 46.9 0.3 1.1e-11 45.2 0.1 2.1 2 0 0 2 2 2 1 PH domain IQ PF00612.27 ELR14086.1 - 0.073 12.9 0.6 0.19 11.6 0.6 1.8 1 0 0 1 1 1 0 IQ calmodulin-binding motif RPEL PF02755.15 ELR14087.1 - 0.00041 19.9 0.0 0.0007 19.2 0.0 1.4 1 0 0 1 1 1 1 RPEL repeat Atrophin-1 PF03154.15 ELR14087.1 - 3.2 5.9 7.4 3.4 5.8 7.4 1.1 1 0 0 1 1 1 0 Atrophin-1 family RhoGAP PF00620.27 ELR14088.1 - 6.9e-23 81.2 0.0 9.2e-23 80.7 0.0 1.1 1 0 0 1 1 1 1 RhoGAP domain HAUS6_N PF14661.6 ELR14092.1 - 2.3e-26 92.8 0.8 2.3e-26 92.8 0.8 2.0 2 0 0 2 2 2 1 HAUS augmin-like complex subunit 6 N-terminus Mt_ATP-synt_D PF05873.12 ELR14092.1 - 0.078 12.8 2.2 0.15 11.9 1.4 1.9 2 0 0 2 2 2 0 ATP synthase D chain, mitochondrial (ATP5H) DUF4446 PF14584.6 ELR14092.1 - 0.85 9.6 3.9 0.52 10.3 0.9 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF4446) P4Ha_N PF08336.11 ELR14092.1 - 1 9.4 6.0 7 6.7 1.0 3.6 3 1 0 3 3 3 0 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region DUF3450 PF11932.8 ELR14092.1 - 9.3 5.5 12.9 3 7.1 6.9 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF3450) tRNA_bind PF01588.20 ELR14093.1 - 2.8e-32 110.7 0.3 4.8e-32 109.9 0.3 1.4 1 0 0 1 1 1 1 Putative tRNA binding domain GST_C_3 PF14497.6 ELR14093.1 - 0.013 15.7 0.1 0.069 13.3 0.1 2.2 1 1 1 2 2 2 0 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 ELR14093.1 - 0.015 15.5 0.0 0.05 13.8 0.0 1.9 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 ELR14093.1 - 0.04 13.9 0.4 0.21 11.6 0.4 2.3 1 1 0 1 1 1 0 Glutathione S-transferase, C-terminal domain Viral_protease PF08715.10 ELR14093.1 - 0.14 11.4 0.0 0.21 10.9 0.0 1.2 1 0 0 1 1 1 0 Papain like viral protease Peptidase_M28 PF04389.17 ELR14094.1 - 1.2e-33 116.4 0.0 1.9e-33 115.8 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M28 zf-RING_UBOX PF13445.6 ELR14095.1 - 5.7e-10 39.1 3.9 1.1e-09 38.1 3.9 1.5 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4 PF00097.25 ELR14095.1 - 2.8e-09 36.7 2.4 4.8e-09 36.0 2.4 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 ELR14095.1 - 3.4e-09 36.7 2.6 5.5e-09 36.0 2.6 1.3 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-C3HC4_2 PF13923.6 ELR14095.1 - 7.2e-09 35.4 2.8 7.2e-09 35.4 2.8 1.8 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) DUF1232 PF06803.12 ELR14095.1 - 3.4e-08 33.2 7.1 5.7e-08 32.4 7.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1232) zf-C3HC4_3 PF13920.6 ELR14095.1 - 2.9e-07 30.2 2.2 4e-07 29.8 2.2 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 ELR14095.1 - 3.5e-07 30.4 4.1 5.8e-07 29.7 4.1 1.4 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.6 ELR14095.1 - 4.7e-05 23.3 1.7 7.7e-05 22.6 1.7 1.4 1 0 0 1 1 1 1 zinc-RING finger domain Prok-RING_4 PF14447.6 ELR14095.1 - 0.0002 21.2 2.2 0.00059 19.6 2.3 1.7 1 1 1 2 2 2 1 Prokaryotic RING finger family 4 zf-Nse PF11789.8 ELR14095.1 - 0.019 14.8 0.6 0.035 13.9 0.6 1.4 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit SbmA_BacA PF05992.12 ELR14095.1 - 0.034 13.6 0.1 0.044 13.2 0.1 1.1 1 0 0 1 1 1 0 SbmA/BacA-like family zf-ANAPC11 PF12861.7 ELR14095.1 - 0.036 14.1 0.7 0.066 13.3 0.7 1.4 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-rbx1 PF12678.7 ELR14095.1 - 0.14 12.5 6.0 0.44 10.9 6.0 1.8 1 1 0 1 1 1 0 RING-H2 zinc finger domain zf-RING_4 PF14570.6 ELR14095.1 - 0.27 11.1 2.1 0.71 9.7 2.1 1.7 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-C3HC4_5 PF17121.5 ELR14095.1 - 1 9.3 4.9 0.68 9.9 1.7 2.3 2 1 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 ELR14095.1 - 2.9 7.7 6.8 0.76 9.6 3.1 2.0 2 0 0 2 2 2 0 RING-like zinc finger SecG PF03840.14 ELR14095.1 - 5.8 7.1 6.4 5.8 7.1 1.5 2.1 1 1 1 2 2 2 0 Preprotein translocase SecG subunit SKG6 PF08693.10 ELR14096.1 - 3.5 7.1 11.1 0.82 9.1 5.1 2.7 2 0 0 2 2 2 0 Transmembrane alpha-helix domain NTP_transferase PF00483.23 ELR14097.1 - 1.4e-30 106.7 0.0 1.9e-30 106.3 0.0 1.1 1 0 0 1 1 1 1 Nucleotidyl transferase Hexapep PF00132.24 ELR14097.1 - 5.3e-09 35.5 10.8 5.8e-05 22.7 1.0 4.9 4 1 1 5 5 5 2 Bacterial transferase hexapeptide (six repeats) NTP_transf_3 PF12804.7 ELR14097.1 - 9.5e-07 29.3 0.0 1.8e-06 28.4 0.0 1.4 1 0 0 1 1 1 1 MobA-like NTP transferase domain DUF4954 PF16314.5 ELR14097.1 - 0.046 11.9 0.1 0.067 11.3 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4954) zf-UBP PF02148.19 ELR14097.1 - 0.056 13.8 0.5 0.14 12.5 0.5 1.6 1 0 0 1 1 1 0 Zn-finger in ubiquitin-hydrolases and other protein Hexapep_2 PF14602.6 ELR14097.1 - 3.4 7.5 6.4 3.1 7.6 0.2 3.3 3 0 0 3 3 3 0 Hexapeptide repeat of succinyl-transferase XRN_M PF17846.1 ELR14098.1 - 3.5e-111 372.3 0.0 6.6e-111 371.4 0.0 1.4 1 0 0 1 1 1 1 Xrn1 helical domain XRN_N PF03159.18 ELR14098.1 - 3.4e-88 295.1 0.0 5.6e-88 294.4 0.0 1.4 1 0 0 1 1 1 1 XRN 5'-3' exonuclease N-terminus zf-CCHC PF00098.23 ELR14098.1 - 0.0004 20.3 0.4 0.001 19.0 0.4 1.7 1 0 0 1 1 1 1 Zinc knuckle Myotub-related PF06602.14 ELR14099.1 - 1e-85 287.8 6.9 1e-85 287.8 6.9 1.5 2 0 0 2 2 2 1 Myotubularin-like phosphatase domain Y_phosphatase3 PF13350.6 ELR14099.1 - 0.00027 21.0 0.0 0.00073 19.6 0.0 1.7 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase PF00102.27 ELR14099.1 - 0.0012 18.5 0.0 0.0027 17.3 0.0 1.6 1 0 0 1 1 1 1 Protein-tyrosine phosphatase DSPc PF00782.20 ELR14099.1 - 0.0057 16.5 0.0 0.016 15.0 0.0 1.7 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Nsp1_C PF05064.13 ELR14099.1 - 0.024 14.4 0.8 0.06 13.2 0.8 1.6 1 0 0 1 1 1 0 Nsp1-like C-terminal region ADIP PF11559.8 ELR14099.1 - 5.8 7.0 11.5 0.71 9.9 3.0 2.8 3 0 0 3 3 3 0 Afadin- and alpha -actinin-Binding Myotub-related PF06602.14 ELR14100.1 - 7.5e-32 110.6 0.0 1e-31 110.2 0.0 1.1 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain Glyco_transf_7N PF13733.6 ELR14100.1 - 0.087 12.5 0.4 0.29 10.8 0.1 1.9 2 0 0 2 2 2 0 N-terminal region of glycosyl transferase group 7 BING4CT PF08149.11 ELR14101.1 - 2.9e-37 126.3 0.4 3.1e-35 119.8 0.0 3.8 4 0 0 4 4 4 1 BING4CT (NUC141) domain WD40 PF00400.32 ELR14101.1 - 2.3e-07 31.4 0.7 0.00016 22.4 0.0 4.7 5 0 0 5 5 5 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ELR14101.1 - 3.1e-06 27.4 0.0 1.5 9.2 0.0 4.2 4 0 0 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ELR14101.1 - 0.0096 15.3 0.0 0.11 11.8 0.0 2.2 2 1 0 2 2 2 1 WD40-like domain HSP70 PF00012.20 ELR14102.1 - 1.5e-89 300.9 17.8 5.9e-89 298.9 5.6 3.8 2 1 2 4 4 4 2 Hsp70 protein TPR_1 PF00515.28 ELR14102.1 - 3.7e-15 55.0 4.7 1.1e-05 25.1 0.1 3.7 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 ELR14102.1 - 1.2e-12 46.9 2.7 4.6e-05 23.2 0.1 4.0 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_8 PF13181.6 ELR14102.1 - 1.1e-07 31.5 1.6 0.011 15.9 0.0 4.0 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.6 ELR14102.1 - 2.8e-06 27.7 6.6 1.3e-05 25.6 0.9 3.6 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_11 PF13414.6 ELR14102.1 - 1.3e-05 24.8 7.2 0.0069 16.1 0.0 3.4 2 1 1 3 3 3 2 TPR repeat MreB_Mbl PF06723.13 ELR14102.1 - 6.6e-05 21.9 2.9 0.0018 17.2 0.2 2.4 2 0 0 2 2 2 1 MreB/Mbl protein Fis1_TPR_C PF14853.6 ELR14102.1 - 0.00011 22.2 11.1 0.01 15.9 0.6 3.3 3 1 1 4 4 3 2 Fis1 C-terminal tetratricopeptide repeat TPR_12 PF13424.6 ELR14102.1 - 0.00029 21.0 3.8 0.0078 16.5 0.1 3.4 2 1 0 3 3 3 1 Tetratricopeptide repeat TPR_7 PF13176.6 ELR14102.1 - 0.00069 19.5 1.8 2.7 8.2 0.0 3.8 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_9 PF13371.6 ELR14102.1 - 0.00076 19.6 0.0 0.0031 17.6 0.0 2.0 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_6 PF13174.6 ELR14102.1 - 0.00091 19.7 0.0 1.1 10.1 0.0 3.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.6 ELR14102.1 - 0.0013 19.3 0.6 0.023 15.5 0.1 3.2 2 0 0 2 2 2 1 Tetratricopeptide repeat ANAPC3 PF12895.7 ELR14102.1 - 0.0015 18.8 3.3 0.0037 17.5 3.3 1.7 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_17 PF13431.6 ELR14102.1 - 0.0068 16.7 4.8 0.15 12.5 0.1 4.0 4 0 0 4 4 4 1 Tetratricopeptide repeat SHNi-TPR PF10516.9 ELR14102.1 - 0.034 13.6 0.8 0.74 9.3 0.0 2.7 2 0 0 2 2 2 0 SHNi-TPR FGGY_C PF02782.16 ELR14102.1 - 0.074 12.8 0.8 0.74 9.5 0.6 2.5 2 0 0 2 2 2 0 FGGY family of carbohydrate kinases, C-terminal domain TPR_16 PF13432.6 ELR14102.1 - 0.095 13.4 3.3 0.27 11.9 0.0 3.2 3 0 0 3 3 2 0 Tetratricopeptide repeat MORN PF02493.20 ELR14103.1 - 2.9e-20 70.9 32.1 6.3e-06 25.8 1.5 5.9 6 0 0 6 6 6 5 MORN repeat Rhomboid PF01694.22 ELR14103.1 - 5.8e-17 62.1 5.3 8.2e-17 61.6 5.3 1.1 1 0 0 1 1 1 1 Rhomboid family DUF4040 PF13244.6 ELR14103.1 - 0.011 15.9 2.0 0.011 15.9 2.0 2.3 2 1 0 2 2 2 0 Domain of unknown function (DUF4040) WAPL PF07814.13 ELR14104.1 - 5.8e-31 107.6 1.9 8.5e-31 107.1 1.9 1.2 1 0 0 1 1 1 1 Wings apart-like protein regulation of heterochromatin Wap1 PF16997.5 ELR14104.1 - 0.13 11.4 0.0 0.21 10.7 0.0 1.4 1 1 0 1 1 1 0 Wap1 domain ALO PF04030.14 ELR14105.1 - 1.2e-81 274.4 3.2 1.8e-81 273.8 3.2 1.3 1 0 0 1 1 1 1 D-arabinono-1,4-lactone oxidase FAD_binding_4 PF01565.23 ELR14105.1 - 8.6e-22 77.4 0.2 1.3e-21 76.8 0.2 1.3 1 0 0 1 1 1 1 FAD binding domain Ras PF00071.22 ELR14106.1 - 3e-17 62.7 0.1 4.1e-15 55.8 0.1 2.2 1 1 0 1 1 1 1 Ras family AAA_16 PF13191.6 ELR14106.1 - 0.0016 18.8 0.1 0.0068 16.8 0.1 2.0 1 1 0 1 1 1 1 AAA ATPase domain EF-hand_8 PF13833.6 ELR14106.1 - 0.0063 16.3 0.0 0.02 14.7 0.0 1.9 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.6 ELR14106.1 - 0.0081 16.0 0.0 6.9 6.9 0.0 3.0 2 0 0 2 2 2 2 EF-hand domain Roc PF08477.13 ELR14106.1 - 0.022 15.0 0.1 0.88 9.8 0.0 2.3 1 1 1 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase EF-hand_7 PF13499.6 ELR14106.1 - 0.033 14.7 0.0 0.28 11.6 0.0 2.6 2 1 0 2 2 2 0 EF-hand domain pair EF-hand_1 PF00036.32 ELR14106.1 - 0.036 13.6 0.0 0.32 10.6 0.0 2.7 2 0 0 2 2 2 0 EF hand AAA_14 PF13173.6 ELR14106.1 - 0.062 13.3 0.0 0.14 12.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain PDEase_I PF00233.19 ELR14107.1 - 1.2e-77 260.8 0.1 1.7e-77 260.4 0.1 1.1 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase HD PF01966.22 ELR14107.1 - 0.06 13.6 0.0 0.15 12.3 0.0 1.8 1 0 0 1 1 1 0 HD domain Mur_ligase_M PF08245.12 ELR14108.1 - 0.13 12.3 0.3 25 4.8 0.0 2.6 2 1 0 2 2 2 0 Mur ligase middle domain ANAPC4_WD40 PF12894.7 ELR14109.1 - 0.00017 21.8 0.0 0.061 13.6 0.0 3.0 3 1 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 ELR14109.1 - 0.03 15.2 0.3 0.25 12.3 0.0 2.6 2 0 0 2 2 2 0 WD domain, G-beta repeat RasGEF PF00617.19 ELR14110.1 - 0.0007 19.8 0.0 0.00084 19.6 0.0 1.2 1 0 0 1 1 1 1 RasGEF domain DUF3395 PF11875.8 ELR14111.1 - 0.0026 17.7 0.0 0.0028 17.5 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF3395) RRM_1 PF00076.22 ELR14112.1 - 4.7e-55 183.3 0.0 1.1e-17 63.6 0.0 3.4 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 ELR14112.1 - 4.9e-07 29.4 0.0 0.045 13.3 0.0 3.3 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RNA_bind PF08675.11 ELR14112.1 - 3.4e-05 23.8 0.0 2.4 8.3 0.0 3.9 3 2 0 3 3 3 2 RNA binding domain RRM_7 PF16367.5 ELR14112.1 - 0.00027 21.0 0.0 0.6 10.3 0.0 3.2 3 1 0 3 3 3 2 RNA recognition motif PHM7_cyt PF14703.6 ELR14112.1 - 0.44 10.8 1.8 5.3 7.2 0.0 3.1 4 0 0 4 4 4 0 Cytosolic domain of 10TM putative phosphate transporter Myosin_head PF00063.21 ELR14113.1 - 1.9e-208 694.0 0.0 9.5e-126 420.7 0.0 3.1 3 1 0 3 3 3 2 Myosin head (motor domain) DIL PF01843.19 ELR14113.1 - 5.2e-21 74.9 0.1 1.7e-20 73.2 0.1 2.0 1 0 0 1 1 1 1 DIL domain IQ PF00612.27 ELR14113.1 - 0.0016 18.0 17.1 0.0056 16.4 2.9 4.4 4 0 0 4 4 4 2 IQ calmodulin-binding motif AAA_16 PF13191.6 ELR14113.1 - 0.014 15.8 0.0 0.014 15.8 0.0 4.4 2 1 0 2 2 2 0 AAA ATPase domain AAA_22 PF13401.6 ELR14113.1 - 0.1 12.9 2.6 0.11 12.7 0.0 2.4 2 0 0 2 2 2 0 AAA domain Myosin_N PF02736.19 ELR14113.1 - 1.1 9.2 8.0 1.2 9.1 0.7 2.6 1 1 1 2 2 2 0 Myosin N-terminal SH3-like domain Acetyltransf_10 PF13673.7 ELR14114.1 - 0.0014 18.6 0.0 0.0024 17.8 0.0 1.3 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 ELR14114.1 - 0.0035 17.7 0.0 0.011 16.2 0.0 1.7 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 ELR14114.1 - 0.013 15.7 0.0 0.046 14.0 0.0 1.7 1 1 0 1 1 1 0 Acetyltransferase (GNAT) family Acetyltransf_9 PF13527.7 ELR14114.1 - 0.16 12.0 0.0 0.35 11.0 0.0 1.7 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain DNA_pol_A PF00476.20 ELR14116.1 - 7.4e-14 51.6 0.0 4.8e-12 45.6 0.0 2.4 1 1 0 1 1 1 1 DNA polymerase family A Glyco_transf_8 PF01501.20 ELR14117.1 - 1.4e-40 139.5 3.1 1.5e-39 136.1 3.1 2.0 1 1 0 1 1 1 1 Glycosyl transferase family 8 EF-G-binding_N PF07299.11 ELR14117.1 - 0.16 12.5 0.0 0.93 10.1 0.0 2.1 2 0 0 2 2 2 0 Elongation factor G-binding protein, N-terminal SAGA-Tad1 PF12767.7 ELR14118.1 - 1.7e-30 106.5 0.0 6.8e-19 68.5 0.0 2.1 1 1 1 2 2 2 2 Transcriptional regulator of RNA polII, SAGA, subunit TAF4 PF05236.14 ELR14118.1 - 2.5e-05 24.2 4.2 0.00025 20.9 0.0 2.6 2 1 1 3 3 3 2 Transcription initiation factor TFIID component TAF4 family TAF PF02969.17 ELR14118.1 - 0.077 13.2 0.0 0.19 11.9 0.0 1.7 1 0 0 1 1 1 0 TATA box binding protein associated factor (TAF) MAGE_N PF12440.8 ELR14118.1 - 0.3 11.8 6.2 0.37 11.5 0.6 2.2 2 0 0 2 2 2 0 Melanoma associated antigen family N terminal Abhydrolase_1 PF00561.20 ELR14119.1 - 1.7e-19 70.5 0.2 3.6e-12 46.5 0.2 2.2 2 0 0 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 ELR14119.1 - 2.4e-14 54.5 1.6 6.1e-14 53.2 1.6 1.6 1 1 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 ELR14119.1 - 2.8e-09 36.6 0.0 6.8e-05 22.2 0.0 2.2 2 0 0 2 2 2 2 Serine aminopeptidase, S33 EHN PF06441.12 ELR14119.1 - 0.0036 17.7 1.5 0.0046 17.3 0.1 1.9 2 0 0 2 2 2 1 Epoxide hydrolase N terminus Peptidase_C1 PF00112.23 ELR14120.1 - 2e-34 119.6 3.6 3e-17 63.4 0.4 4.1 2 2 1 3 3 3 2 Papain family cysteine protease Inhibitor_I29 PF08246.12 ELR14120.1 - 7.9e-13 48.6 2.4 1.3e-12 47.9 2.4 1.4 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Peptidase_C1_2 PF03051.15 ELR14120.1 - 0.0064 15.3 0.0 0.017 13.9 0.0 1.6 1 0 0 1 1 1 1 Peptidase C1-like family zf-Tim10_DDP PF02953.15 ELR14121.1 - 1.8e-15 56.3 0.1 2.9e-15 55.7 0.1 1.4 1 0 0 1 1 1 1 Tim10/DDP family zinc finger PPR_2 PF13041.6 ELR14122.1 - 4.3e-44 148.5 0.5 8.3e-10 38.7 0.1 8.2 5 2 3 8 8 8 8 PPR repeat family PPR PF01535.20 ELR14122.1 - 1.5e-41 137.7 9.6 6.2e-06 26.1 0.1 9.6 10 0 0 10 10 10 8 PPR repeat PPR_1 PF12854.7 ELR14122.1 - 5.2e-33 112.4 0.0 2.8e-06 26.9 0.0 9.3 9 0 0 9 9 9 6 PPR repeat PPR_3 PF13812.6 ELR14122.1 - 4.9e-30 103.4 0.3 3.9e-11 42.9 0.0 7.0 4 2 5 9 9 9 6 Pentatricopeptide repeat domain PPR_long PF17177.4 ELR14122.1 - 2.1e-16 59.9 0.7 4.8e-09 35.9 0.1 3.1 2 1 0 3 3 3 2 Pentacotripeptide-repeat region of PRORP ATR13 PF16829.5 ELR14122.1 - 0.013 15.8 0.1 0.22 11.9 0.0 2.6 2 0 0 2 2 2 0 Avirulence protein ATR13, RxLR effector Exog_C PF18026.1 ELR14122.1 - 0.08 13.0 0.5 43 4.3 0.0 4.3 5 0 0 5 5 5 0 Endo/exonuclease (EXOG) C-terminal domain Rap_GAP PF02145.15 ELR14123.1 - 2.3e-56 190.3 0.0 3.8e-56 189.6 0.0 1.3 1 0 0 1 1 1 1 Rap/ran-GAP UvrD_C PF13361.6 ELR14125.1 - 6e-51 173.9 0.1 1.6e-26 93.6 0.0 2.2 1 1 1 2 2 2 2 UvrD-like helicase C-terminal domain UvrD-helicase PF00580.21 ELR14125.1 - 6.7e-27 94.8 1.8 1.1e-26 94.2 0.0 2.0 2 1 0 2 2 2 1 UvrD/REP helicase N-terminal domain UvrD_C_2 PF13538.6 ELR14125.1 - 1.7e-13 50.2 0.0 4.6e-13 48.8 0.0 1.8 2 0 0 2 2 2 1 UvrD-like helicase C-terminal domain Viral_helicase1 PF01443.18 ELR14125.1 - 4.1e-09 36.5 0.4 4.2e-05 23.4 0.0 2.4 2 0 0 2 2 2 2 Viral (Superfamily 1) RNA helicase AAA_19 PF13245.6 ELR14125.1 - 1.5e-08 35.1 0.4 4.4e-08 33.6 0.1 1.9 2 0 0 2 2 2 1 AAA domain AAA_12 PF13087.6 ELR14125.1 - 0.00063 19.4 0.0 0.0094 15.6 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.6 ELR14125.1 - 0.0013 18.5 0.0 0.0046 16.7 0.0 1.9 1 1 0 1 1 1 1 AAA domain PhoH PF02562.16 ELR14125.1 - 0.1 12.1 0.0 0.2 11.1 0.0 1.4 1 0 0 1 1 1 0 PhoH-like protein Actin PF00022.19 ELR14126.1 - 1.1e-19 70.4 0.0 3.1e-19 68.9 0.0 1.6 1 1 0 1 1 1 1 Actin PRP1_N PF06424.12 ELR14128.1 - 8e-13 49.0 0.0 9.2e-13 48.8 0.0 1.3 1 0 0 1 1 1 1 PRP1 splicing factor, N-terminal TPR_14 PF13428.6 ELR14128.1 - 0.00026 21.5 0.1 0.048 14.5 0.0 2.6 1 1 1 2 2 2 2 Tetratricopeptide repeat Ephrin_rec_like PF07699.13 ELR14130.1 - 3.3e-11 42.8 17.8 4.5e-07 29.5 0.9 2.5 2 0 0 2 2 2 2 Putative ephrin-receptor like Peptidase_M11 PF05548.11 ELR14130.1 - 0.00013 21.2 0.3 0.00025 20.3 0.3 1.4 1 0 0 1 1 1 1 Gametolysin peptidase M11 Reprolysin_3 PF13582.6 ELR14130.1 - 0.0068 16.9 0.1 0.014 15.9 0.1 1.6 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Peptidase_M66 PF10462.9 ELR14130.1 - 0.0086 15.1 0.6 0.014 14.4 0.6 1.2 1 0 0 1 1 1 1 Peptidase M66 MspA PF09203.11 ELR14130.1 - 0.0091 15.9 9.3 3.9 7.3 2.7 4.4 2 1 0 2 2 2 1 MspA Reprolysin_5 PF13688.6 ELR14130.1 - 0.012 15.8 0.2 0.029 14.5 0.2 1.6 1 0 0 1 1 1 0 Metallo-peptidase family M12 Reprolysin_4 PF13583.6 ELR14130.1 - 0.032 13.9 0.2 0.063 12.9 0.2 1.4 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like cEGF PF12662.7 ELR14130.1 - 8.9 6.3 10.2 17 5.5 1.1 2.7 2 0 0 2 2 2 0 Complement Clr-like EGF-like Pkinase_Tyr PF07714.17 ELR14131.1 - 1.8e-45 155.3 0.0 3.1e-45 154.5 0.0 1.4 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ELR14131.1 - 1.6e-41 142.5 0.0 3.3e-41 141.4 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain TRAM1 PF08390.11 ELR14132.1 - 0.0015 18.1 0.2 0.0032 17.1 0.1 1.7 2 0 0 2 2 2 1 TRAM1-like protein MCM PF00493.23 ELR14133.1 - 5.8e-99 329.7 0.0 7.2e-99 329.4 0.0 1.1 1 0 0 1 1 1 1 MCM P-loop domain Mg_chelatase PF01078.21 ELR14133.1 - 7.7e-10 38.5 0.0 1.6e-07 31.0 0.0 2.9 1 1 0 2 2 2 1 Magnesium chelatase, subunit ChlI MCM_lid PF17855.1 ELR14133.1 - 9.8e-08 32.3 0.2 3.2e-07 30.7 0.2 1.9 1 0 0 1 1 1 1 MCM AAA-lid domain AAA_5 PF07728.14 ELR14133.1 - 3.8e-06 26.9 0.0 6.9e-06 26.1 0.0 1.5 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.11 ELR14133.1 - 0.00024 20.9 0.0 0.0013 18.6 0.0 2.1 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 ELR14133.1 - 0.0019 17.9 0.1 0.026 14.3 0.1 2.2 1 1 0 1 1 1 1 Sigma-54 interaction domain AAA PF00004.29 ELR14133.1 - 0.094 13.1 0.2 0.42 11.1 0.2 2.1 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) RVT_2 PF07727.14 ELR14134.1 - 6.4e-53 179.9 0.1 7.5e-52 176.4 0.1 2.0 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_3 PF13456.6 ELR14134.1 - 0.074 12.9 0.0 0.13 12.0 0.0 1.4 1 0 0 1 1 1 0 Reverse transcriptase-like Retrotran_gag_2 PF14223.6 ELR14135.1 - 7e-09 35.5 0.5 7e-08 32.2 0.3 2.4 3 0 0 3 3 3 1 gag-polypeptide of LTR copia-type zf-C2H2_10 PF16588.5 ELR14135.1 - 9.4e-05 22.1 3.0 0.00016 21.3 3.0 1.4 1 0 0 1 1 1 1 C2H2 zinc-finger rve PF00665.26 ELR14136.1 - 1.1e-19 70.8 0.0 2.2e-19 69.8 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 ELR14136.1 - 7.9e-16 57.9 0.3 7.9e-16 57.9 0.3 1.8 2 0 0 2 2 2 1 Integrase zinc binding domain rve_3 PF13683.6 ELR14136.1 - 0.0027 17.4 0.0 0.0062 16.3 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.10 ELR14136.1 - 0.0037 17.5 1.5 0.0095 16.1 0.0 2.2 2 0 0 2 2 2 1 H2C2 zinc finger Phage_integrase PF00589.22 ELR14137.1 - 4e-13 49.5 0.0 5.3e-13 49.1 0.0 1.1 1 0 0 1 1 1 1 Phage integrase family Acetyltransf_6 PF13480.7 ELR14137.1 - 0.11 12.7 1.1 0.23 11.6 0.0 2.2 2 1 0 2 2 2 0 Acetyltransferase (GNAT) domain Ank_2 PF12796.7 ELR14141.1 - 8.9e-90 295.4 38.3 4.4e-10 40.0 0.0 15.7 8 3 6 16 16 16 14 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ELR14141.1 - 2.7e-86 282.9 36.3 2.5e-09 37.5 0.1 19.8 13 5 9 22 22 22 18 Ankyrin repeats (many copies) Ank_5 PF13857.6 ELR14141.1 - 2.6e-78 257.1 47.5 1e-07 32.1 0.0 19.0 11 4 10 21 21 21 18 Ankyrin repeats (many copies) Ank PF00023.30 ELR14141.1 - 2.4e-55 182.7 45.5 8e-05 22.9 0.1 22.9 22 1 0 22 22 22 15 Ankyrin repeat Ank_3 PF13606.6 ELR14141.1 - 6.1e-55 176.7 38.6 0.0013 19.1 0.0 24.5 25 0 0 25 25 25 12 Ankyrin repeat PARP PF00644.20 ELR14141.1 - 5.2e-45 153.4 0.1 2.5e-44 151.2 0.0 2.4 2 0 0 2 2 2 1 Poly(ADP-ribose) polymerase catalytic domain WGR PF05406.15 ELR14141.1 - 1e-22 80.0 0.5 4.6e-22 77.9 0.5 2.3 1 0 0 1 1 1 1 WGR domain PARP_reg PF02877.14 ELR14141.1 - 1e-22 80.7 1.6 1e-22 80.7 1.6 2.9 3 1 0 3 3 3 1 Poly(ADP-ribose) polymerase, regulatory domain AMNp_N PF10423.9 ELR14141.1 - 0.03 14.0 0.0 16 5.1 0.0 4.3 4 1 0 4 4 4 0 Bacterial AMP nucleoside phosphorylase N-terminus AnkUBD PF18418.1 ELR14141.1 - 0.2 11.8 0.6 9 6.5 0.0 3.7 4 0 0 4 4 4 0 Ankyrin ubiquitin-binding domain Tom5 PF10642.9 ELR14141.1 - 4.3 7.4 14.9 1.8 8.6 0.1 3.6 4 0 0 4 4 3 0 Mitochondrial import receptor subunit or translocase Oxidored_molyb PF00174.19 ELR14142.1 - 1.2e-44 151.9 0.0 2.1e-44 151.2 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase molybdopterin binding domain Mo-co_dimer PF03404.16 ELR14142.1 - 2.4e-09 37.3 0.2 4.4e-09 36.5 0.2 1.4 1 0 0 1 1 1 1 Mo-co oxidoreductase dimerisation domain Melibiase_2 PF16499.5 ELR14143.1 - 1.4e-72 244.3 2.4 2.1e-72 243.7 2.4 1.3 1 0 0 1 1 1 1 Alpha galactosidase A Melibiase_C PF17801.1 ELR14143.1 - 1.6e-18 66.5 1.2 1.6e-18 66.5 1.2 2.3 2 0 0 2 2 2 1 Alpha galactosidase C-terminal beta sandwich domain Melibiase PF02065.18 ELR14143.1 - 2.3e-05 23.5 0.1 4.4e-05 22.6 0.1 1.4 1 0 0 1 1 1 1 Melibiase Melibiase_2_C PF17450.2 ELR14143.1 - 0.0054 16.9 0.0 0.0099 16.1 0.0 1.5 1 0 0 1 1 1 1 Alpha galactosidase A C-terminal beta sandwich domain PRP38_assoc PF12871.7 ELR14144.1 - 2.5 8.8 103.3 4.9e+02 1.4 46.0 3.4 1 1 1 2 2 2 0 Pre-mRNA-splicing factor 38-associated hydrophilic C-term SAPS PF04499.15 ELR14145.1 - 0.35 9.6 1.3 0.44 9.3 1.3 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein TFIIA PF03153.13 ELR14145.1 - 0.41 10.6 15.9 0.49 10.3 15.9 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit LapA_dom PF06305.11 ELR14145.1 - 2.6 7.9 4.5 5.9 6.8 4.5 1.6 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain HD PF01966.22 ELR14146.1 - 1.4e-06 28.5 0.1 2.4e-06 27.8 0.1 1.4 1 0 0 1 1 1 1 HD domain HD_4 PF13328.6 ELR14146.1 - 3.4e-05 23.6 0.7 9.8e-05 22.1 0.5 1.8 1 1 0 1 1 1 1 HD domain MIOX PF05153.15 ELR14146.1 - 0.089 12.3 0.2 0.35 10.4 0.2 1.8 1 1 0 1 1 1 0 Myo-inositol oxygenase DUF3565 PF12088.8 ELR14146.1 - 0.76 9.8 2.8 1.3 9.0 0.0 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF3565) Oxidored_molyb PF00174.19 ELR14147.1 - 3.1e-47 160.4 0.0 4.9e-47 159.7 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase molybdopterin binding domain Mo-co_dimer PF03404.16 ELR14147.1 - 9.7e-09 35.4 0.8 2e-08 34.3 0.8 1.5 1 0 0 1 1 1 1 Mo-co oxidoreductase dimerisation domain DeoC PF01791.9 ELR14148.1 - 1.6e-34 119.6 0.1 1.8e-34 119.4 0.1 1.0 1 0 0 1 1 1 1 DeoC/LacD family aldolase GFO_IDH_MocA PF01408.22 ELR14149.1 - 5.8e-16 59.4 0.0 1e-15 58.6 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold NAD_binding_3 PF03447.16 ELR14149.1 - 0.084 13.5 0.0 0.18 12.5 0.0 1.5 1 0 0 1 1 1 0 Homoserine dehydrogenase, NAD binding domain Dickkopf_N PF04706.12 ELR14150.1 - 0.13 12.7 3.9 0.11 13.0 2.4 1.5 1 1 0 1 1 1 0 Dickkopf N-terminal cysteine-rich region ADH_N PF08240.12 ELR14151.1 - 6.4e-26 90.4 1.5 1.2e-25 89.5 1.5 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 ELR14151.1 - 4.6e-10 39.6 0.1 1e-09 38.4 0.1 1.6 1 1 0 1 1 1 1 Zinc-binding dehydrogenase AlaDh_PNT_C PF01262.21 ELR14151.1 - 6.4e-06 25.6 0.2 1.2e-05 24.7 0.2 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain 2-Hacid_dh_C PF02826.19 ELR14151.1 - 4.6e-05 22.8 0.0 8.1e-05 22.1 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain TAXi_N PF14543.6 ELR14151.1 - 0.0037 17.5 0.0 0.006 16.8 0.0 1.3 1 0 0 1 1 1 1 Xylanase inhibitor N-terminal NAD_binding_10 PF13460.6 ELR14151.1 - 0.024 14.5 0.2 0.033 14.1 0.2 1.2 1 0 0 1 1 1 0 NAD(P)H-binding NAD_binding_7 PF13241.6 ELR14151.1 - 0.05 14.1 0.0 0.11 12.9 0.0 1.7 1 1 0 1 1 1 0 Putative NAD(P)-binding GFO_IDH_MocA PF01408.22 ELR14151.1 - 0.051 14.4 0.1 0.089 13.6 0.1 1.5 1 1 0 1 1 1 0 Oxidoreductase family, NAD-binding Rossmann fold 3HCDH_N PF02737.18 ELR14151.1 - 0.12 12.2 0.1 0.18 11.7 0.1 1.2 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain F420_oxidored PF03807.17 ELR14151.1 - 0.14 12.7 0.3 0.27 11.8 0.3 1.5 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent ELFV_dehydrog PF00208.21 ELR14151.1 - 0.15 11.8 0.1 0.23 11.2 0.1 1.2 1 0 0 1 1 1 0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase MCRS_N PF13325.6 ELR14152.1 - 1.9e-09 37.8 0.0 3.6e-09 36.9 0.0 1.4 1 0 0 1 1 1 1 N-terminal region of micro-spherule protein FHA PF00498.26 ELR14152.1 - 3.2e-08 33.8 0.0 5.9e-08 32.9 0.0 1.5 1 0 0 1 1 1 1 FHA domain Sugar_tr PF00083.24 ELR14153.1 - 2e-41 142.4 26.9 2.5e-24 86.0 8.0 2.1 2 0 0 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 ELR14153.1 - 5e-28 98.1 50.6 4.1e-17 62.1 26.9 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_4 PF06779.14 ELR14153.1 - 8.3e-05 22.0 13.6 8.3e-05 22.0 13.6 2.2 2 0 0 2 2 2 1 Uncharacterised MFS-type transporter YbfB Ac76 PF05814.11 ELR14154.1 - 0.12 12.4 1.7 0.38 10.8 0.2 2.2 2 0 0 2 2 2 0 Orf76 (Ac76) Hemerythrin PF01814.23 ELR14155.1 - 2.1e-06 28.4 10.0 5.6e-06 27.0 10.0 1.6 1 1 0 1 1 1 1 Hemerythrin HHE cation binding domain UPF0184 PF03670.13 ELR14155.1 - 0.066 13.6 0.2 0.15 12.4 0.0 1.7 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0184) SET PF00856.28 ELR14156.1 - 3.4e-10 40.6 0.1 1.9e-09 38.1 0.0 2.2 2 1 0 2 2 2 1 SET domain zf-MYND PF01753.18 ELR14156.1 - 0.00048 20.1 10.7 0.00048 20.1 10.7 2.0 2 0 0 2 2 2 1 MYND finger Med31 PF05669.12 ELR14157.1 - 9.8e-29 99.2 11.0 1.5e-28 98.6 11.0 1.3 1 0 0 1 1 1 1 SOH1 Sds3 PF08598.11 ELR14157.1 - 0.13 12.2 2.0 0.63 10.0 0.1 2.0 1 1 0 2 2 2 0 Sds3-like RUN PF02759.19 ELR14158.1 - 2.2e-10 40.6 0.0 2.6e-08 33.9 0.0 2.5 1 1 0 1 1 1 1 RUN domain Shugoshin_N PF07558.11 ELR14158.1 - 0.99 9.3 5.2 0.51 10.2 0.9 2.4 2 0 0 2 2 2 0 Shugoshin N-terminal coiled-coil region ATG16 PF08614.11 ELR14158.1 - 1.1 9.4 14.3 0.043 14.0 6.9 2.2 2 0 0 2 2 2 0 Autophagy protein 16 (ATG16) SAM_1 PF00536.30 ELR14159.1 - 3.1e-10 40.4 0.1 5.7e-10 39.5 0.1 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) RRM_1 PF00076.22 ELR14159.1 - 1.7e-07 31.0 0.0 4.7e-07 29.5 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SAM_2 PF07647.17 ELR14159.1 - 0.00083 19.4 0.1 0.0016 18.5 0.1 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) NUDIX PF00293.28 ELR14160.1 - 1.5e-20 73.6 0.1 2.8e-20 72.7 0.1 1.4 1 0 0 1 1 1 1 NUDIX domain SDA1 PF05285.12 ELR14160.1 - 1.3 8.4 14.9 1.7 8.0 14.9 1.1 1 0 0 1 1 1 0 SDA1 Nop14 PF04147.12 ELR14160.1 - 1.4 7.1 16.1 1.8 6.7 16.1 1.1 1 0 0 1 1 1 0 Nop14-like family CDC45 PF02724.14 ELR14160.1 - 2.7 6.2 12.2 3.5 5.8 12.2 1.1 1 0 0 1 1 1 0 CDC45-like protein NPR3 PF03666.13 ELR14160.1 - 6.5 5.4 8.6 8.6 5.0 8.6 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Apt1 PF10351.9 ELR14160.1 - 7 5.4 7.9 8.4 5.1 7.9 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain PPR_2 PF13041.6 ELR14161.1 - 8.3e-20 70.7 0.0 4.2e-05 23.7 0.0 5.5 4 1 1 5 5 5 4 PPR repeat family PPR PF01535.20 ELR14161.1 - 7.5e-12 44.7 2.7 0.0016 18.6 0.0 5.3 5 0 0 5 5 5 4 PPR repeat PPR_3 PF13812.6 ELR14161.1 - 2.8e-09 36.9 0.0 0.0029 17.6 0.0 4.6 5 0 0 5 5 5 2 Pentatricopeptide repeat domain PPR_long PF17177.4 ELR14161.1 - 0.0052 16.2 1.0 0.12 11.7 0.0 3.1 3 1 0 4 4 4 1 Pentacotripeptide-repeat region of PRORP PPR_1 PF12854.7 ELR14161.1 - 0.0055 16.4 10.9 0.6 9.9 0.0 4.7 5 0 0 5 5 5 2 PPR repeat ECSIT PF06239.11 ELR14161.1 - 0.012 14.7 0.0 2.3 7.3 0.0 3.2 3 0 0 3 3 3 0 Evolutionarily conserved signalling intermediate in Toll pathway Propeptide_C1 PF08127.13 ELR14161.1 - 0.15 11.9 0.0 0.32 10.9 0.0 1.5 1 0 0 1 1 1 0 Peptidase family C1 propeptide cNMP_binding PF00027.29 ELR14162.1 - 3.7e-30 103.8 0.1 4e-19 68.5 0.0 2.9 3 0 0 3 3 3 2 Cyclic nucleotide-binding domain Lactamase_B_2 PF12706.7 ELR14162.1 - 0.0005 19.6 0.1 0.0011 18.5 0.1 1.5 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B PF00753.27 ELR14162.1 - 0.00095 19.2 0.3 0.002 18.2 0.3 1.4 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Tmemb_14 PF03647.13 ELR14164.1 - 1.6e-19 70.4 9.9 2.1e-19 70.0 9.9 1.1 1 0 0 1 1 1 1 Transmembrane proteins 14C Aim19 PF10315.9 ELR14164.1 - 0.0016 18.7 3.3 0.002 18.4 3.3 1.2 1 0 0 1 1 1 1 Altered inheritance of mitochondria protein 19 DUF441 PF04284.13 ELR14164.1 - 0.015 15.3 0.3 0.028 14.4 0.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF441) NAD_Gly3P_dh_C PF07479.14 ELR14165.1 - 3.5e-50 170.0 0.6 6.4e-50 169.1 0.6 1.4 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus NAD_Gly3P_dh_N PF01210.23 ELR14165.1 - 1.1e-43 148.9 0.0 1.7e-43 148.3 0.0 1.3 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus ApbA PF02558.16 ELR14165.1 - 5.8e-09 35.8 0.0 1e-08 35.0 0.0 1.4 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA F420_oxidored PF03807.17 ELR14165.1 - 1.2e-05 25.8 0.0 3.9e-05 24.1 0.0 2.0 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent 3HCDH_N PF02737.18 ELR14165.1 - 0.0018 18.2 0.0 0.0061 16.5 0.0 1.8 1 1 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_binding_2 PF03446.15 ELR14165.1 - 0.0019 18.4 0.0 0.0042 17.3 0.0 1.6 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase Sacchrp_dh_NADP PF03435.18 ELR14165.1 - 0.0051 17.1 0.0 0.011 16.0 0.0 1.6 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain TrkA_N PF02254.18 ELR14165.1 - 0.0057 16.9 0.0 0.023 14.9 0.0 2.1 2 0 0 2 2 2 1 TrkA-N domain DAO PF01266.24 ELR14165.1 - 0.021 14.4 0.0 0.029 14.0 0.0 1.3 1 0 0 1 1 1 0 FAD dependent oxidoreductase Pyr_redox PF00070.27 ELR14165.1 - 0.024 15.2 0.0 0.099 13.2 0.0 2.0 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 ELR14165.1 - 0.033 13.4 0.0 0.058 12.6 0.0 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Shikimate_DH PF01488.20 ELR14165.1 - 0.036 14.1 0.0 0.097 12.7 0.0 1.8 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase NAD_binding_7 PF13241.6 ELR14165.1 - 0.05 14.0 0.0 0.096 13.1 0.0 1.6 1 1 0 1 1 1 0 Putative NAD(P)-binding adh_short PF00106.25 ELR14165.1 - 0.079 12.4 0.0 0.22 10.9 0.0 1.8 1 0 0 1 1 1 0 short chain dehydrogenase E3_binding PF02817.17 ELR14165.1 - 0.13 12.6 0.1 0.51 10.7 0.0 2.1 2 0 0 2 2 1 0 e3 binding domain STAT2_C PF12188.8 ELR14166.1 - 0.0053 16.6 0.3 0.1 12.5 0.1 2.0 1 1 1 2 2 2 2 Signal transducer and activator of transcription 2 C terminal SBP_bac_3 PF00497.20 ELR14167.1 - 0.04 13.3 0.0 4.4 6.7 0.0 2.2 2 0 0 2 2 2 0 Bacterial extracellular solute-binding proteins, family 3 START PF01852.19 ELR14170.1 - 1.1e-13 51.0 0.0 1.8e-13 50.4 0.0 1.2 1 0 0 1 1 1 1 START domain AMP-binding PF00501.28 ELR14171.1 - 2.3e-81 273.6 0.0 3.6e-81 272.9 0.0 1.3 1 0 0 1 1 1 1 AMP-binding enzyme Condensation PF00668.20 ELR14171.1 - 9.6e-19 67.4 0.0 2.3e-17 62.8 0.0 2.7 2 1 0 2 2 2 1 Condensation domain PP-binding PF00550.25 ELR14171.1 - 6.9e-13 48.8 0.0 2e-12 47.3 0.0 1.9 1 0 0 1 1 1 1 Phosphopantetheine attachment site AMP-binding_C PF13193.6 ELR14171.1 - 3e-07 31.3 0.1 1.1e-06 29.5 0.0 2.0 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain Thioesterase PF00975.20 ELR14171.1 - 0.0035 17.5 0.1 0.0077 16.4 0.1 1.6 1 0 0 1 1 1 1 Thioesterase domain START PF01852.19 ELR14171.1 - 0.012 15.0 0.0 0.024 14.1 0.0 1.4 1 0 0 1 1 1 0 START domain WD40 PF00400.32 ELR14173.1 - 3.3e-48 160.6 23.1 3.4e-08 34.0 0.8 8.1 8 0 0 8 8 8 8 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ELR14173.1 - 2.7e-15 56.4 4.2 9.9e-05 22.6 0.1 5.3 2 2 3 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ELR14173.1 - 7.9e-10 38.0 11.9 0.0053 15.5 0.1 5.5 1 1 4 6 6 6 4 Nucleoporin Nup120/160 LisH PF08513.11 ELR14173.1 - 0.00033 20.5 0.1 0.00057 19.8 0.1 1.4 1 0 0 1 1 1 1 LisH Ge1_WD40 PF16529.5 ELR14173.1 - 0.00064 18.8 6.1 0.46 9.4 0.2 3.9 2 1 0 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Cytochrom_D1 PF02239.16 ELR14173.1 - 0.00095 17.8 0.2 0.2 10.1 0.0 2.2 2 0 0 2 2 2 2 Cytochrome D1 heme domain Nucleoporin_N PF08801.11 ELR14173.1 - 0.027 13.2 3.0 8.3 5.0 0.2 3.6 2 2 2 4 4 4 0 Nup133 N terminal like Coatomer_WDAD PF04053.14 ELR14173.1 - 0.11 11.5 0.3 14 4.6 0.2 2.7 2 1 1 3 3 3 0 Coatomer WD associated region Ras PF00071.22 ELR14174.1 - 2e-27 95.8 0.0 3.4e-27 95.0 0.0 1.3 1 0 0 1 1 1 1 Ras family BTB PF00651.31 ELR14174.1 - 6.5e-23 81.1 0.8 8.7e-09 35.6 0.0 4.1 5 0 0 5 5 5 3 BTB/POZ domain LRR_8 PF13855.6 ELR14174.1 - 1.4e-16 60.0 28.1 3.3e-06 26.8 3.6 4.8 3 1 2 5 5 5 4 Leucine rich repeat LRR_4 PF12799.7 ELR14174.1 - 9.3e-10 38.6 31.0 0.00085 19.7 1.3 5.6 4 2 1 5 5 5 4 Leucine Rich repeats (2 copies) Roc PF08477.13 ELR14174.1 - 9.2e-09 35.6 0.0 2.5e-08 34.2 0.0 1.8 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase AAA_18 PF13238.6 ELR14174.1 - 0.0066 17.0 0.0 0.053 14.1 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA PF00004.29 ELR14174.1 - 0.007 16.8 0.0 0.016 15.6 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 ELR14174.1 - 0.0096 16.3 0.0 0.032 14.6 0.0 2.0 1 1 0 1 1 1 1 AAA ATPase domain AAA_5 PF07728.14 ELR14174.1 - 0.02 14.9 0.0 0.081 12.9 0.0 2.0 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_25 PF13481.6 ELR14174.1 - 0.026 14.1 0.0 0.092 12.3 0.0 1.9 2 0 0 2 2 2 0 AAA domain IstB_IS21 PF01695.17 ELR14174.1 - 0.027 14.2 0.0 0.075 12.8 0.0 1.7 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA_24 PF13479.6 ELR14174.1 - 0.033 13.9 0.0 0.072 12.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain RuvB_N PF05496.12 ELR14174.1 - 0.05 13.4 0.0 0.12 12.2 0.0 1.6 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain F-box-like PF12937.7 ELR14175.1 - 3e-11 43.0 1.2 3e-11 43.0 1.2 2.4 2 1 0 2 2 2 1 F-box-like LRR_4 PF12799.7 ELR14175.1 - 2.8e-05 24.4 10.3 7.4 7.2 0.2 6.3 6 1 2 8 8 8 3 Leucine Rich repeats (2 copies) F-box_5 PF18511.1 ELR14175.1 - 0.0017 17.9 0.0 0.0053 16.3 0.1 1.8 2 0 0 2 2 2 1 F-box LRR_6 PF13516.6 ELR14175.1 - 0.0044 17.0 12.4 2.2 8.5 0.0 6.4 8 0 0 8 8 8 2 Leucine Rich repeat LRR_8 PF13855.6 ELR14175.1 - 0.0053 16.5 5.0 1.3 8.8 0.0 4.7 5 1 0 5 5 5 1 Leucine rich repeat PFOR_II PF17147.4 ELR14175.1 - 0.014 15.7 0.0 0.062 13.6 0.0 2.1 2 0 0 2 2 2 0 Pyruvate:ferredoxin oxidoreductase core domain II F-box PF00646.33 ELR14175.1 - 0.025 14.5 0.4 0.12 12.3 0.4 2.2 1 0 0 1 1 1 0 F-box domain NAD_binding_10 PF13460.6 ELR14176.1 - 5e-12 46.1 0.0 1.6e-11 44.4 0.0 1.9 1 1 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 ELR14176.1 - 1.2e-11 44.6 0.0 5.2e-10 39.3 0.0 2.1 2 0 0 2 2 2 1 NmrA-like family 3Beta_HSD PF01073.19 ELR14176.1 - 1.7e-07 30.6 0.0 2.8e-07 29.9 0.0 1.4 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 ELR14176.1 - 2.1e-05 24.1 0.1 5.7e-05 22.7 0.0 1.7 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family DapB_N PF01113.20 ELR14176.1 - 3e-05 24.1 0.0 5.4e-05 23.3 0.0 1.5 1 0 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus Folate_rec PF03024.14 ELR14177.1 - 0.15 12.0 11.8 0.51 10.2 2.8 2.2 1 1 1 2 2 2 0 Folate receptor family Gram_pos_anchor PF00746.21 ELR14177.1 - 0.2 11.6 1.1 0.4 10.7 0.1 2.0 2 0 0 2 2 2 0 LPXTG cell wall anchor motif DUF1035 PF06281.12 ELR14177.1 - 0.38 10.8 2.4 0.76 9.8 2.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1035) Ribosomal_S21e PF01249.18 ELR14178.1 - 1.3e-26 92.5 0.0 1.5e-26 92.3 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein S21e N6-adenineMlase PF10237.9 ELR14179.1 - 2.7e-15 56.5 0.0 4.6e-15 55.8 0.0 1.4 1 0 0 1 1 1 1 Probable N6-adenine methyltransferase zf-CCHC PF00098.23 ELR14179.1 - 0.0034 17.4 5.8 0.0071 16.4 0.9 3.0 2 0 0 2 2 2 1 Zinc knuckle DHHC PF01529.20 ELR14179.1 - 6.8 6.8 21.3 8.1 6.6 6.3 2.5 1 1 1 2 2 2 0 DHHC palmitoyltransferase HEAT PF02985.22 ELR14180.1 - 1.4e-06 28.1 20.8 0.0082 16.3 0.6 6.9 7 0 0 7 7 7 3 HEAT repeat HEAT_2 PF13646.6 ELR14180.1 - 3.7e-05 24.0 8.1 0.16 12.4 0.1 5.8 5 0 0 5 5 5 2 HEAT repeats DOG1 PF14144.6 ELR14180.1 - 0.017 15.4 3.0 5.3 7.3 0.0 3.7 4 0 0 4 4 4 0 Seed dormancy control CbiJ PF02571.14 ELR14180.1 - 0.04 13.4 0.1 0.085 12.3 0.1 1.4 1 0 0 1 1 1 0 Precorrin-6x reductase CbiJ/CobK HEAT_EZ PF13513.6 ELR14180.1 - 0.28 11.7 11.0 0.071 13.6 0.2 4.8 4 0 0 4 4 4 0 HEAT-like repeat Arm PF00514.23 ELR14180.1 - 0.77 9.9 6.6 14 5.9 0.1 3.5 3 0 0 3 3 3 0 Armadillo/beta-catenin-like repeat Adaptin_N PF01602.20 ELR14180.1 - 0.91 8.0 9.4 1.4 7.4 0.0 4.5 5 1 0 5 5 5 0 Adaptin N terminal region RPN2_C PF18004.1 ELR14180.1 - 6 6.8 19.1 0.98 9.3 0.9 2.5 2 0 0 2 2 2 0 26S proteasome regulatory subunit RPN2 C-terminal domain His_Phos_1 PF00300.22 ELR14181.1 - 2.9e-07 30.4 0.3 4.7e-07 29.7 0.3 1.3 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) SBP56 PF05694.11 ELR14182.1 - 4.3e-10 39.0 0.0 1.1e-09 37.6 0.0 1.6 1 1 0 1 1 1 1 56kDa selenium binding protein (SBP56) Rif1_N PF12231.8 ELR14183.1 - 3.8e-28 98.6 1.6 3e-27 95.6 1.6 2.2 1 1 0 1 1 1 1 Rap1-interacting factor 1 N terminal Acetyltransf_1 PF00583.25 ELR14184.1 - 2.6e-11 43.8 0.0 4.1e-11 43.1 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 ELR14184.1 - 3.7e-11 43.0 0.0 6.3e-11 42.3 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 ELR14184.1 - 2.6e-10 40.6 0.0 5.7e-10 39.5 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 ELR14184.1 - 0.00037 20.6 0.0 0.00089 19.3 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 ELR14184.1 - 0.001 19.0 0.0 0.002 18.0 0.0 1.5 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_CG PF14542.6 ELR14184.1 - 0.0017 18.5 0.0 0.0039 17.3 0.0 1.5 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase EF-hand_1 PF00036.32 ELR14185.1 - 4e-20 69.8 1.3 6e-05 22.3 0.1 4.5 5 0 0 5 5 5 4 EF hand EF-hand_5 PF13202.6 ELR14185.1 - 8.4e-20 69.3 0.6 6.9e-05 22.2 0.0 4.4 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.6 ELR14185.1 - 6.4e-19 66.2 0.5 0.00061 19.5 0.0 4.5 5 0 0 5 5 5 4 EF-hand domain EF-hand_7 PF13499.6 ELR14185.1 - 8.6e-15 55.0 0.6 3.7e-07 30.5 0.1 3.4 2 2 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 ELR14185.1 - 1.8e-09 37.3 0.3 0.018 14.9 0.0 4.2 4 0 0 4 4 4 2 EF-hand domain pair Dockerin_1 PF00404.18 ELR14185.1 - 0.0099 16.1 0.5 0.63 10.3 0.0 3.0 3 0 0 3 3 3 1 Dockerin type I domain EF-hand_4 PF12763.7 ELR14185.1 - 0.018 15.0 0.0 0.058 13.4 0.0 1.8 1 1 1 2 2 2 0 Cytoskeletal-regulatory complex EF hand EF-hand_10 PF14788.6 ELR14185.1 - 0.15 12.0 0.0 3.7 7.5 0.0 2.6 2 0 0 2 2 2 0 EF hand VCBS PF13517.6 ELR14185.1 - 0.6 10.7 5.0 6.5 7.4 3.1 3.0 2 1 0 2 2 2 0 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella DUF1648 PF07853.11 ELR14186.1 - 7.6e-11 41.5 0.1 7.6e-11 41.5 0.1 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF1648) EF-hand_6 PF13405.6 ELR14187.1 - 8.4e-23 78.3 0.7 7e-07 28.7 0.1 4.9 5 0 0 5 5 5 4 EF-hand domain EF-hand_1 PF00036.32 ELR14187.1 - 2.7e-22 76.6 5.4 3.6e-07 29.2 0.4 4.8 5 0 0 5 5 5 4 EF hand EF-hand_7 PF13499.6 ELR14187.1 - 9.1e-21 74.1 3.5 6.6e-09 36.1 0.3 4.0 2 1 2 4 4 4 4 EF-hand domain pair EF-hand_5 PF13202.6 ELR14187.1 - 3.9e-19 67.2 7.6 1.9e-05 23.9 0.1 4.8 5 0 0 5 5 5 3 EF hand EF-hand_8 PF13833.6 ELR14187.1 - 4.6e-15 55.2 7.1 8.8e-07 28.7 0.1 4.2 4 0 0 4 4 4 3 EF-hand domain pair EF-hand_4 PF12763.7 ELR14187.1 - 1.5e-07 31.3 0.7 0.0023 17.9 0.1 2.7 2 2 0 2 2 2 2 Cytoskeletal-regulatory complex EF hand p25-alpha PF05517.12 ELR14187.1 - 0.0012 19.0 1.3 0.76 9.9 0.3 2.5 2 1 0 2 2 2 2 p25-alpha Dockerin_1 PF00404.18 ELR14187.1 - 0.0024 18.0 1.1 3.3 8.0 0.2 3.2 3 0 0 3 3 3 1 Dockerin type I domain PBP_GOBP PF01395.22 ELR14187.1 - 0.0037 17.4 1.0 0.0095 16.1 0.4 1.9 2 0 0 2 2 2 1 PBP/GOBP family Fas_alpha_ACP PF18325.1 ELR14187.1 - 0.0095 16.3 0.1 0.017 15.5 0.1 1.4 1 0 0 1 1 1 1 Fatty acid synthase subunit alpha Acyl carrier domain SPARC_Ca_bdg PF10591.9 ELR14187.1 - 0.017 15.4 0.3 7.3 7.0 0.0 3.0 1 1 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region TerB PF05099.13 ELR14187.1 - 0.034 14.1 0.1 1.7 8.6 0.1 2.4 1 1 0 1 1 1 0 Tellurite resistance protein TerB TcdB_toxin_midN PF12256.8 ELR14187.1 - 0.07 12.5 0.3 4.3 6.7 0.1 2.6 1 1 2 3 3 3 0 Insecticide toxin TcdB middle/N-terminal region DUF4326 PF14216.6 ELR14190.1 - 3.2e-15 56.6 0.2 5.3e-15 55.9 0.2 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4326) BK_channel_a PF03493.18 ELR14193.1 - 0.0016 18.5 0.0 0.0028 17.8 0.0 1.3 1 0 0 1 1 1 1 Calcium-activated BK potassium channel alpha subunit mCpol PF18182.1 ELR14193.1 - 0.11 12.9 0.0 0.19 12.0 0.0 1.3 1 0 0 1 1 1 0 minimal CRISPR polymerase domain TrkA_N PF02254.18 ELR14193.1 - 0.14 12.5 0.0 0.4 10.9 0.0 1.7 1 0 0 1 1 1 0 TrkA-N domain CooC_C PF15976.5 ELR14194.1 - 0.077 13.1 0.1 0.097 12.7 0.1 1.1 1 0 0 1 1 1 0 CS1-pili formation C-terminal EF-hand_8 PF13833.6 ELR14194.1 - 0.12 12.2 0.2 0.91 9.4 0.2 2.1 2 0 0 2 2 2 0 EF-hand domain pair TFIIA PF03153.13 ELR14195.1 - 0.0014 18.7 16.4 0.0017 18.5 16.4 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit Macoilin PF09726.9 ELR14195.1 - 0.17 10.4 4.5 0.19 10.3 4.5 1.0 1 0 0 1 1 1 0 Macoilin family DUF1176 PF06674.11 ELR14195.1 - 0.31 10.4 4.4 0.4 10.1 4.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1176) PAT1 PF09770.9 ELR14195.1 - 1.5 7.0 13.3 1.8 6.8 13.3 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Cyt_c_ox_IV PF12270.8 ELR14196.1 - 0.099 12.8 0.2 0.15 12.2 0.2 1.3 1 0 0 1 1 1 0 Cytochrome c oxidase subunit IV RRM_1 PF00076.22 ELR14199.1 - 9e-28 95.9 0.3 7.7e-16 57.7 0.0 3.9 4 1 0 4 4 4 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 ELR14199.1 - 1.4e-07 31.3 0.0 0.34 10.8 0.0 3.4 3 0 0 3 3 3 3 Occluded RNA-recognition motif RRM_7 PF16367.5 ELR14199.1 - 0.00097 19.2 0.6 0.006 16.7 0.0 2.6 4 0 0 4 4 4 1 RNA recognition motif Ammonium_transp PF00909.21 ELR14200.1 - 5.2e-16 58.3 23.5 1.6e-12 46.9 4.0 2.1 1 1 1 2 2 2 2 Ammonium Transporter Family 7tm_7 PF08395.12 ELR14200.1 - 0.0041 16.4 0.1 0.0041 16.4 0.1 2.6 3 0 0 3 3 3 1 7tm Chemosensory receptor DinB_2 PF12867.7 ELR14200.1 - 0.016 15.7 0.5 0.016 15.7 0.5 1.8 2 0 0 2 2 2 0 DinB superfamily DUF4890 PF16231.5 ELR14200.1 - 0.053 14.0 2.3 0.17 12.3 2.3 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4890) Thioredoxin PF00085.20 ELR14201.1 - 0.00041 20.3 0.0 0.0008 19.4 0.0 1.6 1 0 0 1 1 1 1 Thioredoxin LIM PF00412.22 ELR14202.1 - 2.2e-07 31.0 6.3 3.1e-07 30.5 6.3 1.2 1 0 0 1 1 1 1 LIM domain CARMIL_C PF16000.5 ELR14202.1 - 5.3 6.6 7.8 1.2 8.7 4.1 1.6 1 1 1 2 2 2 0 CARMIL C-terminus ECM11 PF15463.6 ELR14203.1 - 0.015 15.9 9.3 0.026 15.1 9.3 1.3 1 0 0 1 1 1 0 Extracellular mutant protein 11 STATa_Ig PF18214.1 ELR14204.1 - 3.4e-42 143.3 1.8 3.4e-42 143.3 1.8 1.8 2 0 0 2 2 2 1 STATa Immunoglobulin-like domain EF-hand_12 PF17901.1 ELR14204.1 - 4.1e-27 94.5 0.7 4.1e-27 94.5 0.7 2.7 2 0 0 2 2 2 1 EF-hand fold domain Dict-STAT-coil PF09267.10 ELR14204.1 - 1e-17 64.5 21.4 1e-17 64.5 21.4 3.2 3 0 0 3 3 3 1 Dictyostelium STAT, coiled coil SH2 PF00017.24 ELR14204.1 - 4.9e-08 33.0 0.2 1.7e-07 31.3 0.0 2.0 2 0 0 2 2 2 1 SH2 domain Cbl_N3 PF02762.14 ELR14204.1 - 0.027 14.3 0.0 0.072 13.0 0.0 1.6 1 0 0 1 1 1 0 CBL proto-oncogene N-terminus, SH2-like domain Allantoicase PF03561.15 ELR14204.1 - 0.73 9.8 3.0 23 4.9 0.0 2.7 2 0 0 2 2 2 0 Allantoicase repeat ARS2 PF04959.13 ELR14205.1 - 6.3e-21 75.6 0.0 2.3e-20 73.8 0.0 1.9 1 0 0 1 1 1 1 Arsenite-resistance protein 2 DUF4187 PF13821.6 ELR14205.1 - 4.4e-08 32.8 0.6 1.1e-07 31.5 0.6 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4187) Pkinase_Tyr PF07714.17 ELR14206.1 - 3.2e-41 141.4 0.0 8.9e-41 139.9 0.0 1.7 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ELR14206.1 - 1e-33 116.8 1.4 2.6e-33 115.5 0.0 2.0 2 0 0 2 2 2 1 Protein kinase domain SH2 PF00017.24 ELR14206.1 - 4.3e-10 39.6 0.0 9.9e-10 38.4 0.0 1.7 1 0 0 1 1 1 1 SH2 domain NPR3 PF03666.13 ELR14206.1 - 0.16 10.7 11.9 0.23 10.2 11.9 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 TFIIF_alpha PF05793.12 ELR14206.1 - 0.34 9.5 24.8 0.48 8.9 24.8 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Ndc1_Nup PF09531.10 ELR14206.1 - 0.86 8.2 3.5 1 7.9 3.5 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Presenilin PF01080.17 ELR14206.1 - 0.89 8.2 10.0 1.3 7.7 10.0 1.2 1 0 0 1 1 1 0 Presenilin SWIRM-assoc_2 PF16496.5 ELR14206.1 - 1.7 7.4 12.0 2.6 6.8 12.0 1.2 1 0 0 1 1 1 0 SWIRM-associated domain at the N-terminal Apt1 PF10351.9 ELR14206.1 - 2.8 6.7 13.3 4.1 6.2 13.3 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain Macoilin PF09726.9 ELR14206.1 - 2.9 6.3 10.5 3.9 5.9 10.5 1.1 1 0 0 1 1 1 0 Macoilin family Zip PF02535.22 ELR14206.1 - 4.6 6.4 5.2 7.5 5.7 5.2 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter Dsh_C PF12316.8 ELR14206.1 - 4.6 7.6 16.0 7.6 6.9 16.0 1.2 1 0 0 1 1 1 0 Segment polarity protein dishevelled (Dsh) C terminal HARE-HTH PF05066.13 ELR14207.1 - 2.1e-10 40.9 0.0 5.3e-10 39.5 0.0 1.8 1 0 0 1 1 1 1 HB1, ASXL, restriction endonuclease HTH domain DUF1318 PF07027.12 ELR14207.1 - 0.01 16.3 2.4 0.03 14.8 0.0 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF1318) RPE65 PF03055.15 ELR14208.1 - 1.2e-34 120.4 0.0 1.3e-34 120.2 0.0 1.0 1 0 0 1 1 1 1 Retinal pigment epithelial membrane protein RPE65 PF03055.15 ELR14209.1 - 4.4e-58 197.6 0.0 5.3e-58 197.3 0.0 1.0 1 0 0 1 1 1 1 Retinal pigment epithelial membrane protein Dynamin_N PF00350.23 ELR14211.1 - 9e-23 81.2 2.4 3.4e-21 76.0 0.0 2.7 2 0 0 2 2 2 1 Dynamin family MMR_HSR1 PF01926.23 ELR14211.1 - 1.6e-05 25.0 0.0 5.9e-05 23.1 0.0 2.1 1 1 0 1 1 1 1 50S ribosome-binding GTPase AIG1 PF04548.16 ELR14211.1 - 0.0031 16.8 0.1 0.54 9.6 0.0 2.5 2 0 0 2 2 2 2 AIG1 family RsgA_GTPase PF03193.16 ELR14211.1 - 0.029 14.3 0.0 0.17 11.8 0.0 2.2 2 0 0 2 2 2 0 RsgA GTPase Hid1 PF12722.7 ELR14211.1 - 0.065 11.4 9.2 0.093 10.9 9.2 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein AAA_16 PF13191.6 ELR14211.1 - 0.63 10.4 3.6 1.6 9.1 0.0 3.4 3 2 0 3 3 3 0 AAA ATPase domain Adaptin_N PF01602.20 ELR14212.1 - 3.2e-119 398.9 3.6 5.2e-111 371.8 4.2 2.0 1 1 1 2 2 2 2 Adaptin N terminal region Alpha_adaptinC2 PF02883.20 ELR14212.1 - 3.5e-24 85.3 0.0 6.1e-24 84.5 0.0 1.4 1 0 0 1 1 1 1 Adaptin C-terminal domain Cnd1 PF12717.7 ELR14212.1 - 1.9e-09 37.7 2.7 0.0001 22.4 0.0 3.2 2 1 0 3 3 3 2 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 ELR14212.1 - 4e-05 23.9 6.1 0.13 12.7 0.1 4.7 4 1 0 4 4 4 2 HEAT repeats HEAT PF02985.22 ELR14212.1 - 0.0081 16.3 4.6 12 6.4 0.1 5.1 5 0 0 5 5 5 1 HEAT repeat Dopey_N PF04118.14 ELR14212.1 - 0.012 14.8 0.1 0.023 13.8 0.1 1.4 1 0 0 1 1 1 0 Dopey, N-terminal RIX1 PF08167.12 ELR14212.1 - 0.031 14.0 0.2 1.7 8.4 0.0 3.4 3 1 0 3 3 3 0 rRNA processing/ribosome biogenesis Histone PF00125.24 ELR14213.1 - 1.6e-17 64.1 0.0 2.4e-17 63.5 0.0 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 Histone_H2A_C PF16211.5 ELR14213.1 - 2.5e-13 49.5 0.7 3.9e-13 48.9 0.7 1.3 1 0 0 1 1 1 1 C-terminus of histone H2A CBFD_NFYB_HMF PF00808.23 ELR14213.1 - 0.00047 20.4 0.0 0.00071 19.8 0.0 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone GDP_Man_Dehyd PF16363.5 ELR14214.1 - 1.4e-64 218.6 0.0 1.9e-64 218.2 0.0 1.2 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 ELR14214.1 - 2.4e-52 177.8 0.1 3.1e-52 177.4 0.1 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 ELR14214.1 - 7.6e-23 80.9 0.1 1.6e-22 79.9 0.1 1.5 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.12 ELR14214.1 - 1.9e-21 76.4 0.1 8e-20 71.1 0.1 2.1 1 1 0 1 1 1 1 Male sterility protein Polysacc_synt_2 PF02719.15 ELR14214.1 - 3.2e-20 72.5 0.0 5.7e-16 58.5 0.0 2.1 1 1 1 2 2 2 2 Polysaccharide biosynthesis protein RmlD_sub_bind PF04321.17 ELR14214.1 - 1.1e-13 51.0 0.0 1.8e-13 50.2 0.0 1.4 1 0 0 1 1 1 1 RmlD substrate binding domain NAD_binding_10 PF13460.6 ELR14214.1 - 1.1e-06 28.6 0.0 2e-06 27.9 0.0 1.4 1 0 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 ELR14214.1 - 0.00013 21.6 0.0 0.0016 18.1 0.1 2.1 1 1 1 2 2 2 1 NmrA-like family Arm PF00514.23 ELR14215.1 - 1.7e-13 50.0 17.3 1.2e-05 25.2 0.1 7.2 8 0 0 8 8 8 3 Armadillo/beta-catenin-like repeat Arm_2 PF04826.13 ELR14215.1 - 1.1e-10 41.4 3.1 8.1e-10 38.6 0.5 2.6 2 1 0 2 2 2 1 Armadillo-like HEAT_2 PF13646.6 ELR14215.1 - 6.9e-05 23.2 13.5 0.004 17.5 0.1 5.6 3 2 3 6 6 6 2 HEAT repeats Adaptin_N PF01602.20 ELR14215.1 - 0.00013 20.7 3.3 0.00078 18.1 1.2 2.5 2 1 1 3 3 3 1 Adaptin N terminal region Proteasom_PSMB PF10508.9 ELR14215.1 - 0.0003 19.5 0.9 0.58 8.6 0.0 3.3 2 1 1 3 3 3 2 Proteasome non-ATPase 26S subunit KAP PF05804.12 ELR14215.1 - 0.00041 18.6 2.8 0.12 10.5 0.0 3.0 2 1 1 3 3 3 1 Kinesin-associated protein (KAP) Cnd1 PF12717.7 ELR14215.1 - 0.0011 19.0 2.7 3.4 7.7 0.0 3.9 2 1 1 3 3 3 2 non-SMC mitotic condensation complex subunit 1 V-ATPase_H_N PF03224.14 ELR14215.1 - 0.0033 16.8 7.6 0.13 11.5 0.8 3.0 1 1 2 3 3 3 3 V-ATPase subunit H V-ATPase_H_C PF11698.8 ELR14215.1 - 0.0044 17.1 0.1 16 5.6 0.0 3.5 3 1 1 4 4 4 0 V-ATPase subunit H RasGEF_N_2 PF14663.6 ELR14215.1 - 0.0064 16.9 3.2 1.9 8.9 0.0 4.1 4 0 0 4 4 4 1 Rapamycin-insensitive companion of mTOR RasGEF_N domain RICTOR_N PF14664.6 ELR14215.1 - 0.039 12.9 0.1 0.72 8.8 0.0 2.7 2 0 0 2 2 2 0 Rapamycin-insensitive companion of mTOR, N-term HEAT_EZ PF13513.6 ELR14215.1 - 0.04 14.4 19.1 0.73 10.4 0.1 6.6 7 0 0 7 7 7 0 HEAT-like repeat UNC45-central PF11701.8 ELR14215.1 - 0.08 12.9 0.2 15 5.5 0.1 3.4 3 0 0 3 3 3 0 Myosin-binding striated muscle assembly central RICTOR_V PF14668.6 ELR14215.1 - 0.086 13.1 0.1 12 6.3 0.0 3.2 2 1 1 3 3 3 0 Rapamycin-insensitive companion of mTOR, domain 5 HEAT PF02985.22 ELR14215.1 - 1.1 9.7 8.3 28 5.3 0.1 5.7 8 0 0 8 8 5 0 HEAT repeat WD40 PF00400.32 ELR14216.1 - 4.4e-35 119.1 25.5 1.3e-07 32.1 0.2 7.2 6 1 0 6 6 6 6 WD domain, G-beta repeat Nup160 PF11715.8 ELR14216.1 - 0.0003 19.6 1.2 0.95 8.0 0.1 3.4 2 1 1 3 3 3 3 Nucleoporin Nup120/160 Frtz PF11768.8 ELR14216.1 - 0.12 10.7 0.0 0.26 9.6 0.0 1.6 2 0 0 2 2 2 0 WD repeat-containing and planar cell polarity effector protein Fritz Pkinase PF00069.25 ELR14217.1 - 3.5e-07 29.8 0.0 4.2e-07 29.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain ENT PF03735.14 ELR14218.1 - 4.6e-25 87.5 0.6 1.1e-24 86.3 0.6 1.6 1 0 0 1 1 1 1 ENT domain Myc-LZ PF02344.15 ELR14218.1 - 0.033 14.3 1.7 0.033 14.3 1.7 1.7 2 0 0 2 2 2 0 Myc leucine zipper domain Microtub_bind PF13931.6 ELR14218.1 - 1.4 9.3 7.1 4.3 7.7 7.1 1.8 1 0 0 1 1 1 0 Kinesin-associated microtubule-binding Paf1 PF03985.13 ELR14218.1 - 7.9 5.4 16.5 14 4.6 16.5 1.4 1 0 0 1 1 1 0 Paf1 Ras PF00071.22 ELR14219.1 - 1.4e-57 193.8 0.0 1.7e-57 193.6 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR14219.1 - 1.4e-36 125.4 0.1 2.1e-36 124.8 0.1 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR14219.1 - 4.4e-14 52.3 0.0 5.3e-14 52.1 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 ELR14219.1 - 1.2e-05 24.9 0.0 1.5e-05 24.5 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit GTP_EFTU PF00009.27 ELR14219.1 - 3.8e-05 23.3 0.0 0.00012 21.6 0.0 1.8 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 ELR14219.1 - 0.00048 20.2 0.0 0.00071 19.6 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 ELR14219.1 - 0.00053 19.4 0.0 0.00062 19.2 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 ELR14219.1 - 0.016 15.1 0.0 2.3 8.1 0.0 2.2 2 0 0 2 2 2 0 RsgA GTPase AAA_7 PF12775.7 ELR14219.1 - 0.055 13.0 0.0 0.09 12.3 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region ABC_transp_aux PF09822.9 ELR14220.1 - 0.22 11.0 0.0 0.3 10.5 0.0 1.1 1 0 0 1 1 1 0 ABC-type uncharacterized transport system Pkinase_Tyr PF07714.17 ELR14221.1 - 1.1e-62 211.7 0.0 1.5e-62 211.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ELR14221.1 - 7.3e-41 140.3 0.1 1.8e-40 139.0 0.0 1.5 2 0 0 2 2 2 1 Protein kinase domain Pkinase_fungal PF17667.1 ELR14221.1 - 2.9e-05 23.0 0.0 2.9e-05 23.0 0.0 1.8 2 1 0 2 2 2 1 Fungal protein kinase Candida_ALS PF05792.13 ELR14221.1 - 7.5 7.2 7.2 3.8 8.2 0.8 2.3 2 0 0 2 2 2 0 Candida agglutinin-like (ALS) UBA2_C PF16195.5 ELR14221.1 - 9.5 7.0 8.9 0.3 11.8 2.2 1.9 2 0 0 2 2 2 0 SUMO-activating enzyme subunit 2 C-terminus Sorting_nexin PF03700.13 ELR14222.1 - 0.017 15.7 2.2 0.017 15.7 2.2 4.4 4 0 0 4 4 4 0 Sorting nexin, N-terminal domain Myc_N PF01056.18 ELR14222.1 - 0.038 13.9 10.0 0.043 13.7 0.3 3.3 3 0 0 3 3 3 0 Myc amino-terminal region PTPRCAP PF15713.5 ELR14222.1 - 0.07 13.4 14.8 0.021 15.1 4.7 2.7 2 0 0 2 2 2 0 Protein tyrosine phosphatase receptor type C-associated Cwf_Cwc_15 PF04889.12 ELR14222.1 - 0.48 10.1 15.4 2.2 8.0 2.4 2.5 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein NOA36 PF06524.12 ELR14222.1 - 1.5 8.1 16.7 2.7 7.2 2.3 2.3 2 0 0 2 2 2 0 NOA36 protein GCIP PF13324.6 ELR14222.1 - 6 6.4 8.8 2 8.0 0.1 2.2 2 0 0 2 2 2 0 Grap2 and cyclin-D-interacting Prothymosin PF03247.14 ELR14222.1 - 8.7 6.8 20.5 4.5 7.8 7.2 2.5 2 0 0 2 2 2 0 Prothymosin/parathymosin family WD40 PF00400.32 ELR14223.1 - 2.9e-37 126.0 11.7 2.8e-07 31.1 0.7 6.8 6 0 0 6 6 6 6 WD domain, G-beta repeat F-box-like PF12937.7 ELR14223.1 - 4.3e-12 45.7 1.3 4.3e-12 45.7 1.3 2.0 2 0 0 2 2 2 1 F-box-like ANAPC4_WD40 PF12894.7 ELR14223.1 - 8e-10 38.9 0.6 0.031 14.6 0.0 4.5 1 1 3 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain F-box PF00646.33 ELR14223.1 - 7.8e-09 35.2 1.8 9.7e-09 34.9 0.2 1.9 2 0 0 2 2 2 1 F-box domain WD40_like PF17005.5 ELR14223.1 - 0.0005 19.5 0.5 0.094 12.0 0.0 2.3 2 1 0 2 2 2 2 WD40-like domain BBS2_Mid PF14783.6 ELR14223.1 - 0.00092 19.2 0.3 0.68 10.0 0.0 4.1 4 1 1 5 5 5 1 Ciliary BBSome complex subunit 2, middle region PQQ_2 PF13360.6 ELR14223.1 - 0.015 14.9 0.0 0.19 11.3 0.0 2.4 1 1 1 2 2 2 0 PQQ-like domain F-box_4 PF15966.5 ELR14223.1 - 0.022 14.6 0.2 0.064 13.2 0.0 1.8 2 0 0 2 2 2 0 F-box PALB2_WD40 PF16756.5 ELR14223.1 - 0.035 13.0 0.6 1.4 7.8 0.1 2.9 3 0 0 3 3 3 0 Partner and localizer of BRCA2 WD40 domain SOG2 PF10428.9 ELR14223.1 - 0.12 11.5 8.6 0.19 10.9 8.6 1.2 1 0 0 1 1 1 0 RAM signalling pathway protein REJ PF02010.15 ELR14224.1 - 4.7e-16 58.6 0.0 9.3e-13 47.8 0.0 3.1 2 1 0 2 2 2 2 REJ domain Mo25 PF08569.11 ELR14225.1 - 4.4e-124 414.1 4.2 4.9e-124 414.0 4.2 1.0 1 0 0 1 1 1 1 Mo25-like Kinesin PF00225.23 ELR14226.1 - 4.3e-110 367.7 0.3 4.3e-110 367.7 0.3 2.8 3 1 0 3 3 3 1 Kinesin motor domain Microtub_bd PF16796.5 ELR14226.1 - 7.4e-22 77.9 2.5 1.4e-21 77.0 0.1 2.8 2 0 0 2 2 2 1 Microtubule binding FlaC_arch PF05377.11 ELR14226.1 - 0.017 15.5 0.9 0.017 15.5 0.9 9.0 7 2 1 9 9 9 0 Flagella accessory protein C (FlaC) RNA_helicase PF00910.22 ELR14226.1 - 0.41 11.1 2.1 13 6.2 2.1 2.9 1 1 0 1 1 1 0 RNA helicase AAA_22 PF13401.6 ELR14226.1 - 1 9.7 0.0 1 9.7 0.0 3.7 3 1 0 3 3 3 0 AAA domain Pkinase PF00069.25 ELR14227.1 - 9.1e-83 277.6 0.4 1.1e-82 277.4 0.4 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR14227.1 - 4.7e-41 140.8 0.1 6.2e-41 140.4 0.1 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 ELR14227.1 - 4.2e-05 23.0 0.2 6e-05 22.5 0.2 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 ELR14227.1 - 0.018 15.0 0.0 0.21 11.5 0.0 2.1 1 1 1 2 2 2 0 Phosphotransferase enzyme family YrbL-PhoP_reg PF10707.9 ELR14227.1 - 0.021 14.3 0.0 0.021 14.3 0.0 2.0 3 0 0 3 3 3 0 PhoP regulatory network protein YrbL FAD_binding_1 PF00667.20 ELR14228.1 - 1.9e-57 194.4 0.0 3.4e-57 193.6 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain Flavodoxin_1 PF00258.25 ELR14228.1 - 5.7e-35 120.6 0.2 1e-34 119.8 0.2 1.5 1 0 0 1 1 1 1 Flavodoxin NAD_binding_1 PF00175.21 ELR14228.1 - 1.4e-16 61.1 0.0 3.1e-16 60.0 0.0 1.6 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain Flavodoxin_5 PF12724.7 ELR14228.1 - 0.076 13.3 0.0 0.25 11.6 0.0 1.9 1 0 0 1 1 1 0 Flavodoxin domain DUF3995 PF13160.6 ELR14228.1 - 0.13 12.6 0.5 27 5.2 0.6 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3995) SAD_SRA PF02182.17 ELR14229.1 - 1.1e-10 41.5 0.0 2e-10 40.6 0.0 1.4 1 0 0 1 1 1 1 SAD/SRA domain YL1 PF05764.13 ELR14229.1 - 0.00043 20.5 6.5 0.00043 20.5 6.5 2.2 2 0 0 2 2 2 1 YL1 nuclear protein DNMT1-RFD PF12047.8 ELR14229.1 - 0.24 11.5 0.1 3.8 7.6 0.0 2.5 3 0 0 3 3 3 0 Cytosine specific DNA methyltransferase replication foci domain FmiP_Thoc5 PF09766.9 ELR14229.1 - 0.38 10.0 1.6 0.62 9.3 1.6 1.3 1 0 0 1 1 1 0 Fms-interacting protein/Thoc5 CDC45 PF02724.14 ELR14229.1 - 0.93 7.7 13.8 1.5 7.0 13.8 1.3 1 0 0 1 1 1 0 CDC45-like protein 2OG-FeII_Oxy_2 PF13532.6 ELR14230.1 - 0.00071 19.8 0.0 0.00079 19.7 0.0 1.1 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DUF4028 PF13220.6 ELR14230.1 - 0.038 13.8 0.0 0.049 13.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4028) zf-4CXXC_R1 PF10497.9 ELR14231.1 - 6.2e-07 29.6 8.3 1.4e-06 28.4 8.3 1.6 1 0 0 1 1 1 1 Zinc-finger domain of monoamine-oxidase A repressor R1 zf-His_Me_endon PF05551.11 ELR14232.1 - 9.8e-08 32.3 2.4 3.8e-07 30.4 2.4 2.0 1 1 0 1 1 1 1 Zinc-binding loop region of homing endonuclease Ank_2 PF12796.7 ELR14234.1 - 1.3e-13 51.3 0.1 2.5e-13 50.4 0.1 1.5 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ELR14234.1 - 1.1e-10 41.8 0.0 1.6e-06 28.5 0.1 2.5 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 ELR14234.1 - 1.8e-10 40.8 2.4 4.3e-05 23.7 0.3 3.3 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 ELR14234.1 - 1.9e-09 37.0 0.1 0.0066 16.9 0.0 3.5 3 0 0 3 3 3 2 Ankyrin repeat Ank PF00023.30 ELR14234.1 - 1.2e-08 35.0 0.9 0.042 14.3 0.0 3.9 4 0 0 4 4 4 2 Ankyrin repeat DUF4392 PF14336.6 ELR14236.1 - 2.1e-13 50.4 0.0 2.3e-13 50.3 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4392) HU-CCDC81_euk_2 PF18289.1 ELR14237.1 - 0.039 14.1 0.0 0.066 13.4 0.0 1.3 1 0 0 1 1 1 0 CCDC81 eukaryotic HU domain 2 MarR_2 PF12802.7 ELR14237.1 - 0.064 13.2 0.0 0.089 12.7 0.0 1.2 1 0 0 1 1 1 0 MarR family HTH_28 PF13518.6 ELR14237.1 - 0.19 11.9 0.0 0.27 11.4 0.0 1.2 1 0 0 1 1 1 0 Helix-turn-helix domain Arrestin_C PF02752.22 ELR14238.1 - 0.00027 21.4 0.0 0.00054 20.4 0.0 1.5 1 0 0 1 1 1 1 Arrestin (or S-antigen), C-terminal domain RVT_1 PF00078.27 ELR14239.1 - 6.7e-06 25.8 0.2 2.3e-05 24.0 0.2 1.9 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF563 PF04577.14 ELR14240.1 - 6.5e-07 29.7 1.1 3.9e-05 23.9 1.1 2.3 1 1 0 1 1 1 1 Protein of unknown function (DUF563) RTC PF01137.21 ELR14241.1 - 3.7e-67 225.8 0.0 1.9e-66 223.4 0.0 1.9 1 1 0 1 1 1 1 RNA 3'-terminal phosphate cyclase RTC_insert PF05189.13 ELR14241.1 - 3.7e-24 85.2 1.5 7e-24 84.3 1.3 1.6 2 0 0 2 2 2 1 RNA 3'-terminal phosphate cyclase (RTC), insert domain Rap1a PF18602.1 ELR14241.1 - 0.00065 20.0 0.1 0.0066 16.7 0.0 2.3 2 0 0 2 2 2 1 Rap1a immunity proteins Med2 PF11214.8 ELR14242.1 - 0.087 13.0 0.1 2.5 8.3 0.0 2.4 2 0 0 2 2 2 0 Mediator complex subunit 2 Prefoldin PF02996.17 ELR14242.1 - 0.14 12.1 0.1 1 9.3 0.0 2.4 2 1 1 3 3 3 0 Prefoldin subunit EPTP PF03736.17 ELR14242.1 - 0.15 12.0 0.1 0.33 11.0 0.1 1.5 1 0 0 1 1 1 0 EPTP domain NUDIX PF00293.28 ELR14243.1 - 4.4e-17 62.4 0.4 7.7e-17 61.6 0.4 1.4 1 0 0 1 1 1 1 NUDIX domain Hydrolase PF00702.26 ELR14243.1 - 0.00096 19.5 0.1 0.0014 19.0 0.1 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 ELR14243.1 - 0.066 13.3 0.0 0.11 12.6 0.0 1.4 1 0 0 1 1 1 0 Haloacid dehalogenase-like hydrolase Rep_fac_C PF08542.11 ELR14243.1 - 0.11 13.0 0.0 0.21 12.0 0.0 1.4 1 0 0 1 1 1 0 Replication factor C C-terminal domain D-ser_dehydrat PF14031.6 ELR14244.1 - 2.1e-20 73.2 0.5 2.8e-18 66.4 0.0 2.3 2 0 0 2 2 2 2 Putative serine dehydratase domain Ala_racemase_N PF01168.20 ELR14244.1 - 7.5e-07 29.0 0.1 9.8e-07 28.6 0.1 1.2 1 0 0 1 1 1 1 Alanine racemase, N-terminal domain Acetyltransf_1 PF00583.25 ELR14245.1 - 6.4e-13 49.0 0.1 1.3e-12 48.0 0.1 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 ELR14245.1 - 2.4e-09 37.2 0.0 4e-09 36.5 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 ELR14245.1 - 9.1e-09 35.6 0.0 1.5e-08 34.9 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 ELR14245.1 - 3.1e-05 23.9 0.0 6.2e-05 22.9 0.0 1.4 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_9 PF13527.7 ELR14245.1 - 0.007 16.4 0.0 0.011 15.8 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 ELR14245.1 - 0.019 15.1 0.0 0.034 14.3 0.0 1.3 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase FtsX PF02687.21 ELR14245.1 - 0.27 11.7 2.8 0.61 10.6 2.8 1.5 1 0 0 1 1 1 0 FtsX-like permease family OATP PF03137.20 ELR14245.1 - 0.29 9.4 4.4 0.46 8.7 4.4 1.2 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family CLU PF13236.6 ELR14246.1 - 1.1e-24 87.5 0.0 1.9e-24 86.7 0.0 1.3 1 0 0 1 1 1 1 Clustered mitochondria eIF3_p135 PF12807.7 ELR14246.1 - 8.5e-07 29.2 0.0 2.5e-06 27.6 0.0 1.8 1 0 0 1 1 1 1 Translation initiation factor eIF3 subunit 135 Amidinotransf PF02274.17 ELR14247.1 - 3.1e-15 56.1 0.0 3.4e-15 56.0 0.0 1.0 1 0 0 1 1 1 1 Amidinotransferase CLU PF13236.6 ELR14248.1 - 1.2e-15 58.0 0.0 1.9e-15 57.3 0.0 1.3 1 0 0 1 1 1 1 Clustered mitochondria DUF3439 PF11921.8 ELR14248.1 - 0.51 10.3 5.0 1.1 9.2 5.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) DUF5320 PF17253.2 ELR14248.1 - 3.2 8.9 8.7 24 6.1 7.6 2.7 2 0 0 2 2 2 0 Family of unknown function (DUF5320) DEAD PF00270.29 ELR14249.1 - 9.5e-46 155.8 1.2 1.4e-45 155.2 0.1 1.9 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ELR14249.1 - 4.5e-19 68.8 0.0 2.1e-18 66.6 0.0 2.2 1 1 0 1 1 1 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 ELR14249.1 - 3.5e-16 59.2 0.7 6.2e-15 55.2 0.3 2.7 2 0 0 2 2 2 1 Domain of unknown function (DUF4217) ResIII PF04851.15 ELR14249.1 - 9.1e-09 35.5 0.0 2.4e-08 34.2 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit CMS1 PF14617.6 ELR14249.1 - 0.018 14.4 0.0 0.018 14.4 0.0 1.7 2 0 0 2 2 2 0 U3-containing 90S pre-ribosomal complex subunit Pkinase PF00069.25 ELR14250.1 - 7.7e-21 74.6 0.0 8.4e-21 74.5 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR14250.1 - 1.3e-13 50.8 0.0 1.4e-13 50.7 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 ELR14250.1 - 0.0021 17.5 0.0 0.0023 17.3 0.0 1.0 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 ELR14250.1 - 0.0033 16.2 0.0 0.0034 16.2 0.0 1.0 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 ELR14250.1 - 0.027 14.4 0.0 0.03 14.2 0.0 1.0 1 0 0 1 1 1 0 Phosphotransferase enzyme family Mo-co_dimer PF03404.16 ELR14252.1 - 2.7e-05 24.2 0.1 0.0013 18.7 0.0 2.0 1 1 1 2 2 2 2 Mo-co oxidoreductase dimerisation domain NAD_binding_10 PF13460.6 ELR14252.1 - 0.06 13.2 0.1 0.069 13.0 0.1 1.1 1 0 0 1 1 1 0 NAD(P)H-binding BNR PF02012.20 ELR14252.1 - 0.14 12.3 0.0 0.42 10.8 0.0 1.9 1 0 0 1 1 1 0 BNR/Asp-box repeat SCF PF02404.15 ELR14254.1 - 0.24 10.7 0.5 0.38 10.1 0.5 1.3 1 0 0 1 1 1 0 Stem cell factor efThoc1 PF11957.8 ELR14255.1 - 2.1e-76 257.6 3.7 5.9e-76 256.1 3.7 1.7 1 1 0 1 1 1 1 THO complex subunit 1 transcription elongation factor Ebp2 PF05890.12 ELR14255.1 - 0.031 13.8 3.8 0.056 13.0 3.8 1.5 1 0 0 1 1 1 0 Eukaryotic rRNA processing protein EBP2 FBA PF04300.13 ELR14256.1 - 1e-19 70.9 0.0 1.1e-19 70.8 0.0 1.0 1 0 0 1 1 1 1 F-box associated region RrnaAD PF00398.20 ELR14257.1 - 1.2e-41 142.5 0.0 1.5e-41 142.2 0.0 1.0 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Methyltransf_25 PF13649.6 ELR14257.1 - 0.0072 17.0 0.0 0.015 16.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain FbpA PF05833.11 ELR14257.1 - 0.019 13.7 0.0 0.024 13.4 0.0 1.1 1 0 0 1 1 1 0 Fibronectin-binding protein A N-terminus (FbpA) Methyltransf_9 PF08003.11 ELR14257.1 - 0.099 11.5 0.0 0.16 10.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1698) DUF3251 PF11622.8 ELR14257.1 - 0.18 11.4 0.0 0.34 10.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3251) Methyltransf_23 PF13489.6 ELR14257.1 - 0.2 11.5 0.0 0.38 10.6 0.0 1.5 2 0 0 2 2 2 0 Methyltransferase domain VWA_2 PF13519.6 ELR14258.1 - 1.3e-08 35.4 0.0 2.6e-08 34.4 0.0 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain vWA-TerF-like PF10138.9 ELR14258.1 - 0.00017 21.7 0.0 0.00077 19.6 0.0 1.9 1 1 0 1 1 1 1 vWA found in TerF C terminus Copine PF07002.16 ELR14258.1 - 0.0027 17.2 0.2 0.31 10.4 0.0 2.2 1 1 0 2 2 2 2 Copine VWA PF00092.28 ELR14258.1 - 0.0069 16.6 0.0 0.045 14.0 0.0 2.0 1 1 0 1 1 1 1 von Willebrand factor type A domain Glycos_transf_2 PF00535.26 ELR14259.1 - 4e-23 82.1 0.1 1.3e-22 80.4 0.1 1.8 2 0 0 2 2 2 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 ELR14259.1 - 3e-11 43.7 0.5 5.9e-11 42.7 0.5 1.4 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_2 PF10111.9 ELR14259.1 - 0.0037 16.8 0.0 0.0058 16.1 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 DnaJ_C PF01556.18 ELR14260.1 - 6.9e-28 97.6 0.0 1.8e-27 96.2 0.0 1.7 2 0 0 2 2 2 1 DnaJ C terminal domain F-box-like PF12937.7 ELR14260.1 - 7.5e-09 35.4 0.2 1.5e-08 34.4 0.2 1.6 1 0 0 1 1 1 1 F-box-like DnaJ_CXXCXGXG PF00684.19 ELR14260.1 - 4.6e-05 23.7 6.3 0.0009 19.6 6.3 2.4 1 1 0 1 1 1 1 DnaJ central domain F-box PF00646.33 ELR14260.1 - 0.0005 19.9 0.2 0.00087 19.1 0.2 1.4 1 0 0 1 1 1 1 F-box domain Anti-TRAP PF15777.5 ELR14260.1 - 1.7 8.7 6.0 1.7 8.7 0.5 2.4 2 0 0 2 2 2 0 Tryptophan RNA-binding attenuator protein inhibitory protein RCC1_2 PF13540.6 ELR14261.1 - 9.1e-11 41.3 3.7 0.00089 19.0 0.1 3.7 3 0 0 3 3 3 3 Regulator of chromosome condensation (RCC1) repeat RCC1 PF00415.18 ELR14261.1 - 2.8e-06 27.8 13.9 0.00015 22.3 0.1 4.3 3 1 0 3 3 3 2 Regulator of chromosome condensation (RCC1) repeat GRDP-like PF07173.12 ELR14263.1 - 2.3e-15 57.5 3.3 3e-09 37.7 0.0 3.7 4 0 0 4 4 4 2 Glycine-rich domain-containing protein-like F-box-like PF12937.7 ELR14263.1 - 1.1e-07 31.7 0.3 4.3e-07 29.7 0.0 2.2 3 0 0 3 3 3 1 F-box-like F-box PF00646.33 ELR14263.1 - 3.2e-06 26.9 0.0 6.3e-06 25.9 0.0 1.5 1 0 0 1 1 1 1 F-box domain DUF4781 PF16013.5 ELR14264.1 - 0.4 9.5 3.5 0.71 8.6 3.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4781) RPN1_RPN2_N PF17781.1 ELR14265.1 - 7.5e-120 400.0 0.5 1.3e-119 399.2 0.5 1.3 1 0 0 1 1 1 1 RPN1/RPN2 N-terminal domain PC_rep PF01851.22 ELR14265.1 - 3.3e-28 96.7 30.2 5e-07 29.8 0.3 9.3 10 0 0 10 10 10 6 Proteasome/cyclosome repeat RPN1_C PF18051.1 ELR14265.1 - 5.8e-27 93.5 0.2 1.2e-26 92.5 0.2 1.5 1 0 0 1 1 1 1 26S proteasome non-ATPase regulatory subunit RPN1 C-terminal HEAT_2 PF13646.6 ELR14265.1 - 1.8e-07 31.4 1.0 0.031 14.7 0.0 4.6 5 0 0 5 5 5 2 HEAT repeats HEAT PF02985.22 ELR14265.1 - 0.1 12.9 0.0 11 6.6 0.0 3.6 3 0 0 3 3 3 0 HEAT repeat HEAT_EZ PF13513.6 ELR14265.1 - 0.26 11.9 1.7 3.4 8.3 0.2 3.5 3 1 1 4 4 4 0 HEAT-like repeat CLU PF13236.6 ELR14266.1 - 2e-52 178.2 0.0 3.1e-52 177.6 0.0 1.3 1 0 0 1 1 1 1 Clustered mitochondria eIF3_p135 PF12807.7 ELR14266.1 - 7.3e-05 22.9 0.6 0.00018 21.6 0.6 1.6 1 0 0 1 1 1 1 Translation initiation factor eIF3 subunit 135 DUF3246 PF11596.8 ELR14266.1 - 2.6 7.4 5.9 1.4 8.3 3.3 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3246) Pkinase_Tyr PF07714.17 ELR14267.1 - 7.2e-66 222.1 0.0 9.6e-66 221.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ELR14267.1 - 2.2e-48 164.9 0.0 3.3e-48 164.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_fungal PF17667.1 ELR14267.1 - 1.6e-05 23.9 0.1 4e-05 22.6 0.0 1.6 2 0 0 2 2 2 1 Fungal protein kinase Kinase-like PF14531.6 ELR14267.1 - 3.2e-05 23.4 0.0 4.3e-05 23.0 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 ELR14267.1 - 0.032 13.6 0.1 0.17 11.2 0.0 2.0 2 1 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 ELR14267.1 - 0.091 12.7 0.1 5.7 6.8 0.1 2.4 1 1 1 2 2 2 0 Phosphotransferase enzyme family FTA2 PF13095.6 ELR14267.1 - 0.1 12.2 0.0 10 5.7 0.0 2.5 1 1 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Hamartin PF04388.12 ELR14267.1 - 0.24 10.0 8.6 0.29 9.8 8.6 1.1 1 0 0 1 1 1 0 Hamartin protein Pkinase_Tyr PF07714.17 ELR14268.1 - 1.6e-41 142.3 0.0 2.3e-41 141.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ELR14268.1 - 5.5e-36 124.3 0.0 1e-35 123.4 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain CDC27 PF09507.10 ELR14268.1 - 0.00062 19.3 32.1 0.00085 18.8 32.1 1.1 1 0 0 1 1 1 1 DNA polymerase subunit Cdc27 ABC1 PF03109.16 ELR14268.1 - 0.017 15.3 0.0 0.042 14.0 0.0 1.6 1 0 0 1 1 1 0 ABC1 family APH PF01636.23 ELR14268.1 - 0.019 14.9 0.6 0.05 13.5 0.5 1.7 1 1 0 1 1 1 0 Phosphotransferase enzyme family PPP4R2 PF09184.11 ELR14268.1 - 0.078 12.6 13.3 0.14 11.7 13.3 1.3 1 0 0 1 1 1 0 PPP4R2 Kinase-like PF14531.6 ELR14268.1 - 0.089 12.1 0.0 0.15 11.4 0.0 1.3 1 0 0 1 1 1 0 Kinase-like Vfa1 PF08432.10 ELR14268.1 - 0.19 12.0 20.9 0.37 11.1 20.9 1.5 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 RR_TM4-6 PF06459.12 ELR14268.1 - 0.87 9.4 18.0 1.4 8.6 18.0 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 SAPS PF04499.15 ELR14268.1 - 1.7 7.3 7.6 2.6 6.7 7.6 1.3 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein CDC45 PF02724.14 ELR14268.1 - 3.7 5.7 17.9 5.1 5.3 17.9 1.1 1 0 0 1 1 1 0 CDC45-like protein dUTPase PF00692.19 ELR14269.1 - 5.1e-42 142.6 0.0 6.4e-42 142.3 0.0 1.0 1 0 0 1 1 1 1 dUTPase RFX_DNA_binding PF02257.15 ELR14270.1 - 3.4e-13 50.0 0.1 1e-12 48.5 0.0 1.8 2 0 0 2 2 2 1 RFX DNA-binding domain Porin_3 PF01459.22 ELR14272.1 - 1.5e-32 113.2 7.8 2.4e-32 112.5 7.8 1.3 1 1 0 1 1 1 1 Eukaryotic porin ARID PF01388.21 ELR14273.1 - 4.7e-13 49.6 0.1 9.9e-13 48.6 0.1 1.5 1 0 0 1 1 1 1 ARID/BRIGHT DNA binding domain BAF250_C PF12031.8 ELR14273.1 - 3.1e-05 23.4 0.1 8e-05 22.1 0.1 1.7 1 0 0 1 1 1 1 SWI/SNF-like complex subunit BAF250/Osa Adaptin_binding PF10199.9 ELR14273.1 - 0.00088 19.9 24.0 0.014 16.0 10.5 3.4 3 0 0 3 3 3 2 Alpha and gamma adaptin binding protein p34 Utp14 PF04615.13 ELR14273.1 - 9.7 4.6 40.5 1.7 7.2 28.2 2.3 2 0 0 2 2 2 0 Utp14 protein NHL PF01436.21 ELR14274.1 - 5.7e-08 32.4 0.4 0.0009 19.2 0.0 3.3 3 0 0 3 3 3 3 NHL repeat PhyH PF05721.13 ELR14276.1 - 1e-41 143.5 0.0 1.3e-41 143.2 0.0 1.2 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) DUF4792 PF16040.5 ELR14276.1 - 0.12 12.3 0.0 0.97 9.4 0.0 2.3 3 0 0 3 3 3 0 Domain of unknown function (DUF4792) LRRNT_2 PF08263.12 ELR14277.1 - 0.014 15.7 1.9 0.014 15.7 1.9 1.8 2 0 0 2 2 2 0 Leucine rich repeat N-terminal domain DUF2561 PF10812.8 ELR14277.1 - 0.043 13.9 0.0 0.043 13.9 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2561) LRR_8 PF13855.6 ELR14278.1 - 3.1e-14 52.5 12.9 6.4e-07 29.0 3.7 4.0 2 1 2 4 4 4 4 Leucine rich repeat LRR_4 PF12799.7 ELR14278.1 - 0.00015 22.1 16.4 0.0053 17.1 2.0 4.2 1 1 5 6 6 6 4 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 ELR14278.1 - 0.00028 21.0 11.6 3.6 8.5 0.1 5.8 5 1 0 5 5 5 1 Leucine Rich Repeat DUF1641 PF07849.11 ELR14278.1 - 0.053 13.4 0.0 0.12 12.3 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1641) TRP PF06011.12 ELR14278.1 - 0.19 10.4 17.6 0.16 10.7 15.5 1.9 2 1 0 2 2 2 0 Transient receptor potential (TRP) ion channel DUF1230 PF06799.11 ELR14278.1 - 0.85 9.7 3.7 0.46 10.6 0.3 2.2 2 0 0 2 2 2 0 Conserved in the green lineage and diatoms 27 LRR_6 PF13516.6 ELR14278.1 - 2.7 8.3 11.4 24 5.3 0.1 6.0 8 0 0 8 8 8 0 Leucine Rich repeat HEAT PF02985.22 ELR14279.1 - 1e-07 31.6 5.9 3.6 8.1 0.0 7.8 7 0 0 7 7 7 3 HEAT repeat HEAT_EZ PF13513.6 ELR14279.1 - 0.00011 22.6 11.3 0.13 12.8 0.1 8.1 7 2 1 8 8 8 2 HEAT-like repeat HEAT_2 PF13646.6 ELR14279.1 - 0.00016 22.0 7.0 16 5.9 0.0 7.2 8 0 0 8 8 8 1 HEAT repeats Arm PF00514.23 ELR14279.1 - 0.012 15.7 0.0 1.9 8.7 0.0 4.0 4 0 0 4 4 4 0 Armadillo/beta-catenin-like repeat IFRD PF05004.13 ELR14279.1 - 0.03 13.4 0.2 0.62 9.1 0.0 3.2 3 0 0 3 3 3 0 Interferon-related developmental regulator (IFRD) Cnd1 PF12717.7 ELR14279.1 - 0.14 12.2 0.4 9.4 6.2 0.1 4.0 4 0 0 4 4 4 0 non-SMC mitotic condensation complex subunit 1 RTP1_C1 PF10363.9 ELR14279.1 - 0.15 12.3 0.7 29 4.9 0.0 4.0 3 0 0 3 3 3 0 Required for nuclear transport of RNA pol II C-terminus 1 SapB_2 PF03489.17 ELR14279.1 - 0.16 12.1 0.1 0.67 10.1 0.1 2.2 1 0 0 1 1 1 0 Saposin-like type B, region 2 MCM PF00493.23 ELR14280.1 - 1.1e-98 328.8 0.0 1.7e-98 328.2 0.0 1.3 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 ELR14280.1 - 1.4e-35 121.9 0.0 2.6e-35 121.0 0.0 1.4 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 ELR14280.1 - 5.8e-27 93.9 2.0 1.3e-26 92.9 2.0 1.6 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_N PF14551.6 ELR14280.1 - 1.3e-16 61.1 0.1 4.5e-16 59.3 0.0 2.0 2 0 0 2 2 2 1 MCM N-terminal domain Mg_chelatase PF01078.21 ELR14280.1 - 3.8e-07 29.7 0.0 0.00034 20.1 0.0 2.5 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 ELR14280.1 - 4.2e-07 30.0 0.1 1.9e-06 27.9 0.0 2.2 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 ELR14280.1 - 0.0032 17.9 3.1 0.039 14.3 0.1 3.0 2 1 0 2 2 2 1 AAA ATPase domain AAA_3 PF07726.11 ELR14280.1 - 0.005 16.7 0.0 0.015 15.2 0.0 1.8 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA PF00004.29 ELR14280.1 - 0.072 13.5 0.0 0.78 10.2 0.0 2.4 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) RPA_C PF08784.11 ELR14280.1 - 0.098 13.3 0.1 0.32 11.7 0.1 1.9 1 0 0 1 1 1 0 Replication protein A C terminal Oberon_cc PF16312.5 ELR14280.1 - 0.15 12.0 0.2 0.37 10.7 0.2 1.6 1 0 0 1 1 1 0 Coiled-coil region of Oberon AAA_22 PF13401.6 ELR14280.1 - 0.34 11.2 2.5 8.9 6.6 0.1 3.3 2 1 1 3 3 3 0 AAA domain SH2 PF00017.24 ELR14282.1 - 2.2e-06 27.7 0.0 4.1e-06 26.8 0.0 1.5 1 0 0 1 1 1 1 SH2 domain Pkinase_Tyr PF07714.17 ELR14284.1 - 4.5e-47 160.5 0.0 6.3e-47 160.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ELR14284.1 - 1e-45 156.2 0.0 1.4e-45 155.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain ABC1 PF03109.16 ELR14284.1 - 0.13 12.4 0.0 0.25 11.5 0.0 1.4 1 0 0 1 1 1 0 ABC1 family CHCH PF06747.13 ELR14285.1 - 0.00065 19.8 5.8 1.7 8.8 0.0 4.6 3 1 0 3 3 3 2 CHCH domain Cation_efflux PF01545.21 ELR14286.1 - 6.4e-32 110.9 5.6 8.8e-32 110.5 5.6 1.2 1 0 0 1 1 1 1 Cation efflux family ZT_dimer PF16916.5 ELR14286.1 - 1.8e-09 37.6 0.0 4.1e-09 36.5 0.0 1.5 1 0 0 1 1 1 1 Dimerisation domain of Zinc Transporter UPF0139 PF03669.13 ELR14287.1 - 5.8e-17 61.3 0.1 7e-14 51.5 0.2 2.1 1 1 1 2 2 2 2 Uncharacterised protein family (UPF0139) Rav1p_C PF12234.8 ELR14288.1 - 6.2e-52 176.9 0.0 6.5e-45 153.7 0.0 4.2 2 1 0 2 2 2 2 RAVE protein 1 C terminal WD40 PF00400.32 ELR14288.1 - 1.7e-16 60.3 12.2 4.9e-05 24.0 0.0 10.3 11 1 0 11 11 11 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ELR14288.1 - 6.4e-10 39.2 0.0 0.0014 18.9 0.0 5.5 4 1 1 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain TFIIIC_delta PF12657.7 ELR14288.1 - 0.0071 16.3 0.2 0.058 13.3 0.1 2.5 2 1 0 2 2 2 1 Transcription factor IIIC subunit delta N-term eIF2A PF08662.11 ELR14288.1 - 0.046 13.6 0.0 0.6 9.9 0.0 2.5 3 0 0 3 3 3 0 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 ELR14288.1 - 0.15 10.6 0.0 10 4.6 0.0 2.4 2 0 0 2 2 2 0 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 ELR14288.1 - 0.16 10.9 0.0 22 3.9 0.0 2.7 3 0 0 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein DUF4896 PF16237.5 ELR14288.1 - 0.18 11.7 0.1 0.35 10.8 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4896) Nop14 PF04147.12 ELR14288.1 - 4.7 5.3 5.5 7.1 4.7 5.5 1.2 1 0 0 1 1 1 0 Nop14-like family Cwf_Cwc_15 PF04889.12 ELR14288.1 - 4.7 6.9 11.5 0.05 13.3 3.1 1.8 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein Astro_capsid_p PF12226.8 ELR14288.1 - 5.3 6.1 5.1 9.8 5.2 5.1 1.3 1 0 0 1 1 1 0 Turkey astrovirus capsid protein AIRC PF00731.20 ELR14289.1 - 1.5e-59 199.8 2.0 3e-59 198.8 2.0 1.5 1 0 0 1 1 1 1 AIR carboxylase ATP-grasp PF02222.22 ELR14289.1 - 1.3e-46 158.3 0.0 4.4e-46 156.6 0.0 1.9 2 0 0 2 2 2 1 ATP-grasp domain SAICAR_synt PF01259.18 ELR14289.1 - 9e-46 156.5 0.0 1.4e-45 155.9 0.0 1.2 1 0 0 1 1 1 1 SAICAR synthetase PurK_C PF17769.1 ELR14289.1 - 1.1e-14 53.9 0.4 2e-14 53.0 0.4 1.5 1 0 0 1 1 1 1 Phosphoribosylaminoimidazole carboxylase C-terminal domain Dala_Dala_lig_C PF07478.13 ELR14289.1 - 2.6e-05 23.9 0.0 5.3e-05 22.9 0.0 1.4 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus DIM PF08194.12 ELR14290.1 - 0.21 11.8 4.8 0.42 10.8 4.8 1.5 1 0 0 1 1 1 0 DIM protein Es2 PF09751.9 ELR14291.1 - 4.6e-56 191.4 31.3 6.8e-56 190.8 18.2 3.8 2 1 0 2 2 2 1 Nuclear protein Es2 GspL_C PF12693.7 ELR14291.1 - 3.8 7.3 12.4 13 5.6 9.3 2.3 2 0 0 2 2 2 0 GspL periplasmic domain Methyltransf_11 PF08241.12 ELR14292.1 - 8.6e-07 29.5 0.0 2.4e-06 28.1 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ELR14292.1 - 2.6e-06 27.3 0.0 0.073 12.9 0.0 2.4 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_25 PF13649.6 ELR14292.1 - 3.5e-05 24.4 0.0 0.0029 18.3 0.0 2.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 ELR14292.1 - 0.00086 19.2 0.0 0.0029 17.5 0.0 1.9 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 ELR14292.1 - 0.0036 18.0 0.0 0.015 16.0 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_29 PF03141.16 ELR14292.1 - 0.045 12.3 0.0 0.069 11.7 0.0 1.2 1 0 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase Ubie_methyltran PF01209.18 ELR14292.1 - 0.16 11.2 0.0 8.1 5.7 0.0 2.1 2 0 0 2 2 2 0 ubiE/COQ5 methyltransferase family DZR PF12773.7 ELR14292.1 - 0.63 10.1 5.4 0.93 9.6 1.7 2.4 2 0 0 2 2 2 0 Double zinc ribbon Myb_DNA-bind_6 PF13921.6 ELR14293.1 - 7.1e-07 29.4 0.3 5.8e-06 26.5 0.1 2.1 2 0 0 2 2 2 1 Myb-like DNA-binding domain Myb_DNA-binding PF00249.31 ELR14293.1 - 8.4e-07 29.1 0.4 2.6e-06 27.5 0.3 1.9 2 0 0 2 2 2 1 Myb-like DNA-binding domain F-box-like PF12937.7 ELR14294.1 - 1.9e-07 30.9 0.1 5.1e-07 29.5 0.1 1.8 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ELR14294.1 - 0.028 14.3 0.0 0.071 13.0 0.0 1.6 1 0 0 1 1 1 0 F-box domain 2-Hacid_dh_C PF02826.19 ELR14296.1 - 6.5e-64 214.6 0.0 9.5e-64 214.0 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 ELR14296.1 - 7.1e-28 96.9 0.0 9.1e-28 96.6 0.0 1.1 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.15 ELR14296.1 - 6.1e-05 23.2 0.0 0.0001 22.5 0.0 1.4 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase IlvN PF07991.12 ELR14296.1 - 0.04 13.5 0.1 0.17 11.5 0.0 2.1 3 0 0 3 3 3 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain PreAtp-grasp PF18604.1 ELR14297.1 - 0.0075 15.9 0.0 0.015 14.9 0.0 1.6 1 0 0 1 1 1 1 Pre ATP-grasp domain Abhydrolase_2 PF02230.16 ELR14298.1 - 0.00023 21.0 0.0 0.00038 20.3 0.0 1.3 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase Peptidase_S9 PF00326.21 ELR14298.1 - 0.00044 19.8 0.0 0.00065 19.2 0.0 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family Hydrolase_4 PF12146.8 ELR14298.1 - 0.00047 19.5 0.0 0.00076 18.8 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_4 PF08386.10 ELR14298.1 - 0.039 14.1 0.0 0.057 13.5 0.0 1.3 1 0 0 1 1 1 0 TAP-like protein DLH PF01738.18 ELR14298.1 - 0.049 13.2 0.0 0.087 12.4 0.0 1.3 1 0 0 1 1 1 0 Dienelactone hydrolase family Pkinase PF00069.25 ELR14299.1 - 4.4e-32 111.5 0.0 1.8e-21 76.7 0.0 3.2 1 1 2 3 3 3 3 Protein kinase domain Kelch_5 PF13854.6 ELR14299.1 - 6.8e-23 80.2 20.5 0.00021 21.2 0.1 6.4 6 0 0 6 6 6 5 Kelch motif Kelch_3 PF13415.6 ELR14299.1 - 7.2e-19 67.6 24.9 6.5e-08 32.7 0.3 8.2 7 1 1 8 8 8 5 Galactose oxidase, central domain Pkinase_Tyr PF07714.17 ELR14299.1 - 9.6e-17 61.1 0.0 4.5e-13 49.1 0.0 3.1 1 1 0 2 2 2 1 Protein tyrosine kinase Kelch_6 PF13964.6 ELR14299.1 - 6.4e-16 58.0 17.0 0.0002 21.5 0.1 6.6 6 1 0 6 6 6 4 Kelch motif Kelch_4 PF13418.6 ELR14299.1 - 6.8e-16 58.0 20.7 3.9e-09 36.4 0.2 6.8 6 2 1 7 7 6 3 Galactose oxidase, central domain Kelch_1 PF01344.25 ELR14299.1 - 3.1e-12 45.9 22.6 4.1e-05 23.1 0.1 5.7 6 0 0 6 6 6 4 Kelch motif Kelch_2 PF07646.15 ELR14299.1 - 1.5e-11 43.8 7.3 0.17 11.9 0.2 6.1 6 0 0 6 6 6 4 Kelch motif PB1 PF00564.24 ELR14299.1 - 6.5e-07 29.2 0.0 1.3e-06 28.2 0.0 1.4 1 0 0 1 1 1 1 PB1 domain Kinase-like PF14531.6 ELR14299.1 - 1.3e-05 24.7 0.0 0.14 11.4 0.0 2.1 2 0 0 2 2 2 2 Kinase-like Pkinase_fungal PF17667.1 ELR14299.1 - 0.042 12.6 0.0 0.074 11.8 0.0 1.3 1 0 0 1 1 1 0 Fungal protein kinase Kdo PF06293.14 ELR14299.1 - 0.082 12.3 0.0 0.13 11.6 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family SNAP PF14938.6 ELR14300.1 - 2.4e-23 83.0 13.0 3.5e-23 82.4 13.0 1.2 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_12 PF13424.6 ELR14300.1 - 2.7e-06 27.6 14.9 2e-05 24.8 5.7 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_1 PF00515.28 ELR14300.1 - 0.00041 20.1 10.9 0.0052 16.6 0.1 3.9 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 ELR14300.1 - 0.00061 19.7 0.7 0.00061 19.7 0.7 5.4 4 2 2 6 6 6 2 Tetratricopeptide repeat TPR_MalT PF17874.1 ELR14300.1 - 0.0092 15.4 4.3 0.0092 15.4 4.3 2.0 1 1 1 2 2 2 1 MalT-like TPR region TPR_7 PF13176.6 ELR14300.1 - 0.013 15.4 11.2 1.5 9.0 0.1 5.2 4 1 1 5 5 5 0 Tetratricopeptide repeat TOM20_plant PF06552.12 ELR14300.1 - 0.015 15.1 2.1 0.12 12.1 0.7 2.3 1 1 1 2 2 2 0 Plant specific mitochondrial import receptor subunit TOM20 DUF410 PF04190.13 ELR14300.1 - 0.016 15.0 0.4 0.026 14.3 0.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF410) TPR_8 PF13181.6 ELR14300.1 - 0.022 14.9 9.7 0.19 12.0 0.2 4.3 3 1 1 4 4 4 0 Tetratricopeptide repeat Ribosomal_60s PF00428.19 ELR14300.1 - 0.038 14.6 7.0 0.038 14.6 7.0 2.9 3 1 1 4 4 3 0 60s Acidic ribosomal protein TPR_6 PF13174.6 ELR14300.1 - 0.038 14.6 11.0 0.86 10.4 0.4 5.8 2 2 4 6 6 6 0 Tetratricopeptide repeat HEAT_PBS PF03130.16 ELR14300.1 - 0.37 11.6 4.6 7.6 7.5 0.6 3.5 4 0 0 4 4 3 0 PBS lyase HEAT-like repeat Cytomega_UL84 PF06284.11 ELR14300.1 - 0.95 7.8 5.1 1.4 7.3 5.1 1.1 1 0 0 1 1 1 0 Cytomegalovirus UL84 protein TPR_10 PF13374.6 ELR14300.1 - 2.2 8.3 6.6 2.5 8.1 0.1 3.7 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_14 PF13428.6 ELR14300.1 - 7.7 7.6 19.4 2.8 9.0 0.2 5.7 4 2 4 8 8 6 0 Tetratricopeptide repeat CTD_bind PF04818.13 ELR14301.1 - 1.2e-11 45.2 0.4 1.2e-11 45.2 0.4 2.5 2 0 0 2 2 2 1 RNA polymerase II-binding domain. CREPT PF16566.5 ELR14301.1 - 2.5e-11 43.9 12.7 6e-11 42.7 12.7 1.7 1 0 0 1 1 1 1 Cell-cycle alteration and expression-elevated protein in tumour DUF1043 PF06295.12 ELR14301.1 - 0.0034 17.4 8.4 0.008 16.2 8.4 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1043) DUF3552 PF12072.8 ELR14301.1 - 0.0096 15.4 11.0 0.023 14.1 11.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF3552) DUF4559 PF15112.6 ELR14301.1 - 0.021 14.5 9.0 0.048 13.3 9.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4559) DUF2477 PF10631.9 ELR14301.1 - 0.035 14.8 4.7 0.45 11.2 1.9 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2477) DUF1974 PF09317.11 ELR14301.1 - 0.043 13.4 10.6 0.98 8.9 0.4 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF1974) CT_C_D PF02682.16 ELR14301.1 - 0.19 11.4 1.8 8.9 6.0 0.0 2.2 2 0 0 2 2 2 0 Carboxyltransferase domain, subdomain C and D Spt20 PF12090.8 ELR14301.1 - 0.22 11.1 11.9 0.36 10.4 11.9 1.4 1 0 0 1 1 1 0 Spt20 family SRP54_N PF02881.19 ELR14301.1 - 0.33 11.2 3.9 1.1 9.5 0.1 3.1 3 0 0 3 3 3 0 SRP54-type protein, helical bundle domain SKA1 PF07160.12 ELR14301.1 - 1.2 8.9 12.5 2.3 8.0 12.1 1.8 1 1 0 1 1 1 0 Spindle and kinetochore-associated protein 1 V_ATPase_I PF01496.19 ELR14301.1 - 1.4 6.7 6.9 1.9 6.3 6.9 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family UQ_con PF00179.26 ELR14302.1 - 2.8e-43 146.9 0.0 3.2e-43 146.8 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UEV PF05743.13 ELR14302.1 - 0.0027 17.6 0.0 0.0046 16.8 0.0 1.4 1 0 0 1 1 1 1 UEV domain RWD PF05773.22 ELR14302.1 - 0.012 15.9 0.0 0.016 15.5 0.0 1.2 1 0 0 1 1 1 0 RWD domain Nas2_N PF18265.1 ELR14303.1 - 2.9e-26 91.2 0.0 3.7e-26 90.8 0.0 1.1 1 0 0 1 1 1 1 Nas2 N_terminal domain PDZ_6 PF17820.1 ELR14303.1 - 1.8e-06 27.7 0.4 2.8e-05 23.8 0.4 2.5 1 1 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 ELR14303.1 - 3.7e-05 24.0 0.0 0.0001 22.6 0.0 1.7 1 1 0 1 1 1 1 PDZ domain GRASP55_65 PF04495.14 ELR14303.1 - 0.00035 20.9 0.0 0.0016 18.8 0.0 1.9 1 1 0 1 1 1 1 GRASP55/65 PDZ-like domain PDZ PF00595.24 ELR14303.1 - 0.068 13.5 0.0 0.17 12.2 0.0 1.7 1 0 0 1 1 1 0 PDZ domain ABC1 PF03109.16 ELR14304.1 - 0.0012 19.0 0.0 0.0023 18.1 0.0 1.4 1 0 0 1 1 1 1 ABC1 family RIO1 PF01163.22 ELR14304.1 - 0.0049 16.5 0.0 0.0099 15.5 0.0 1.4 1 0 0 1 1 1 1 RIO1 family Pkinase PF00069.25 ELR14304.1 - 0.013 14.8 0.0 0.019 14.4 0.0 1.1 1 0 0 1 1 1 0 Protein kinase domain APH PF01636.23 ELR14304.1 - 0.016 15.1 0.0 0.016 15.1 0.0 2.8 3 1 0 3 3 3 0 Phosphotransferase enzyme family Kdo PF06293.14 ELR14304.1 - 0.16 11.3 0.0 0.36 10.1 0.0 1.5 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family DNA_pol_E_B PF04042.16 ELR14305.1 - 4.7e-28 98.0 0.0 5.8e-28 97.7 0.0 1.1 1 0 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B RNB PF00773.19 ELR14307.1 - 4.4e-50 170.9 0.0 7.2e-50 170.2 0.0 1.2 1 0 0 1 1 1 1 RNB domain EF-hand_1 PF00036.32 ELR14309.1 - 2.8e-37 123.5 7.4 4e-07 29.1 0.1 6.7 6 0 0 6 6 6 5 EF hand EF-hand_7 PF13499.6 ELR14309.1 - 7.1e-35 119.3 4.7 7.8e-13 48.7 0.3 4.9 4 0 0 4 4 4 4 EF-hand domain pair EF-hand_6 PF13405.6 ELR14309.1 - 2.3e-31 105.0 6.3 5.8e-05 22.7 0.0 7.1 5 1 0 6 6 6 5 EF-hand domain EF-hand_5 PF13202.6 ELR14309.1 - 1.1e-26 91.0 11.3 5.6e-07 28.8 0.1 6.4 7 0 0 7 7 6 5 EF hand Arm PF00514.23 ELR14309.1 - 4.6e-25 86.8 13.3 0.00091 19.2 0.1 8.1 8 0 0 8 8 8 7 Armadillo/beta-catenin-like repeat EF-hand_8 PF13833.6 ELR14309.1 - 1.8e-16 59.7 9.7 2.7e-06 27.1 0.1 5.5 2 1 2 4 4 4 4 EF-hand domain pair EF-hand_9 PF14658.6 ELR14309.1 - 3.9e-12 46.3 0.3 4.2e-07 30.2 0.0 3.7 3 1 1 4 4 3 2 EF-hand domain PB1 PF00564.24 ELR14309.1 - 3.2e-10 39.8 0.4 3.9e-09 36.3 0.1 3.0 3 0 0 3 3 3 1 PB1 domain HEAT_2 PF13646.6 ELR14309.1 - 6.6e-08 32.8 5.8 0.02 15.3 4.1 4.2 2 1 1 3 3 3 3 HEAT repeats DUF3349 PF11829.8 ELR14309.1 - 0.00017 22.3 1.5 0.082 13.7 0.1 4.4 4 0 0 4 4 4 1 Protein of unknown function (DUF3349) HEAT PF02985.22 ELR14309.1 - 0.00036 20.5 4.2 0.87 10.0 0.0 4.4 5 0 0 5 5 3 2 HEAT repeat HEAT_EZ PF13513.6 ELR14309.1 - 0.0008 19.9 4.8 0.91 10.1 0.0 5.6 5 1 1 6 6 6 1 HEAT-like repeat SPARC_Ca_bdg PF10591.9 ELR14309.1 - 0.0057 17.0 8.3 8.9 6.7 0.1 4.9 3 2 2 5 5 5 0 Secreted protein acidic and rich in cysteine Ca binding region MMS19_C PF12460.8 ELR14309.1 - 0.013 14.7 3.2 1.8 7.6 0.2 3.2 2 1 1 3 3 3 0 RNAPII transcription regulator C-terminal Adaptin_N PF01602.20 ELR14309.1 - 0.036 12.6 0.0 0.19 10.2 0.0 1.9 1 1 1 2 2 2 0 Adaptin N terminal region EF-hand_4 PF12763.7 ELR14309.1 - 0.043 13.8 4.3 35 4.4 0.3 4.6 2 2 2 4 4 4 0 Cytoskeletal-regulatory complex EF hand EAP30 PF04157.16 ELR14309.1 - 0.048 12.9 0.0 0.16 11.2 0.0 1.9 1 0 0 1 1 1 0 EAP30/Vps36 family Dockerin_1 PF00404.18 ELR14309.1 - 0.05 13.8 1.6 10 6.4 0.7 3.0 2 1 0 2 2 2 0 Dockerin type I domain Proteasom_PSMB PF10508.9 ELR14309.1 - 0.06 11.8 0.3 0.15 10.6 0.3 1.6 1 0 0 1 1 1 0 Proteasome non-ATPase 26S subunit RTP1_C1 PF10363.9 ELR14309.1 - 0.061 13.5 0.1 0.25 11.6 0.1 2.1 1 0 0 1 1 1 0 Required for nuclear transport of RNA pol II C-terminus 1 PPP5 PF08321.12 ELR14309.1 - 0.086 13.1 0.1 1.5 9.1 0.0 2.8 2 0 0 2 2 2 0 PPP5 TPR repeat region p25-alpha PF05517.12 ELR14309.1 - 0.15 12.2 2.4 5.8 7.1 0.0 3.6 2 2 0 3 3 3 0 p25-alpha PNPase PF03726.14 ELR14309.1 - 0.16 12.5 2.3 9.8 6.8 0.1 3.5 3 0 0 3 3 2 0 Polyribonucleotide nucleotidyltransferase, RNA binding domain zf-CRD PF17979.1 ELR14310.1 - 3.2e-23 82.6 0.3 3.2e-23 82.6 0.3 2.8 2 1 0 2 2 1 1 Cysteine rich domain with multizinc binding regions FHA PF00498.26 ELR14310.1 - 4e-15 55.9 0.0 7.5e-15 55.0 0.0 1.5 1 0 0 1 1 1 1 FHA domain zf-C3HC4_2 PF13923.6 ELR14310.1 - 9.8e-07 28.5 14.3 9.8e-07 28.5 14.3 2.0 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 ELR14310.1 - 3.3e-06 26.8 12.9 3.3e-06 26.8 12.9 2.8 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 ELR14310.1 - 5.4e-06 26.2 14.9 1.7e-05 24.6 14.9 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 ELR14310.1 - 4.3e-05 23.8 15.0 4.3e-05 23.8 15.0 2.4 3 0 0 3 3 1 1 Ring finger domain Yop-YscD_cpl PF16697.5 ELR14310.1 - 0.0006 20.1 0.0 0.0012 19.1 0.0 1.5 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain zf-CCHH PF10283.9 ELR14310.1 - 0.079 13.0 4.4 0.063 13.3 1.5 2.3 2 0 0 2 2 2 0 PBZ domain zf-RING_6 PF14835.6 ELR14310.1 - 0.13 12.2 8.0 0.27 11.2 8.0 1.5 1 0 0 1 1 1 0 zf-RING of BARD1-type protein CENP-B_dimeris PF09026.10 ELR14310.1 - 0.19 12.1 27.0 0.065 13.6 11.9 3.4 3 0 0 3 3 3 0 Centromere protein B dimerisation domain zf-RING_4 PF14570.6 ELR14310.1 - 1.1 9.1 17.8 0.18 11.6 12.8 2.4 2 0 0 2 2 1 0 RING/Ubox like zinc-binding domain RXT2_N PF08595.11 ELR14310.1 - 2.4 8.2 14.5 12 5.9 6.9 3.1 3 0 0 3 3 3 0 RXT2-like, N-terminal Prok-RING_4 PF14447.6 ELR14310.1 - 4.3 7.3 20.8 0.039 13.8 11.7 2.3 2 0 0 2 2 2 0 Prokaryotic RING finger family 4 BAT2_N PF07001.11 ELR14310.1 - 6.7 7.1 10.0 12 6.3 10.0 1.3 1 0 0 1 1 1 0 BAT2 N-terminus zf-RING_UBOX PF13445.6 ELR14310.1 - 7.7 6.6 22.0 0.028 14.4 11.0 2.7 3 0 0 3 3 2 0 RING-type zinc-finger DUF3169 PF11368.8 ELR14310.1 - 8.2 5.9 5.7 4.7 6.6 0.7 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF3169) AAA PF00004.29 ELR14311.1 - 7.5e-32 110.5 0.0 1.1e-31 110.0 0.0 1.2 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 ELR14311.1 - 2e-17 62.7 0.4 3.4e-12 46.0 0.0 2.5 2 0 0 2 2 2 2 AAA+ lid domain AAA_16 PF13191.6 ELR14311.1 - 4.1e-05 24.0 0.7 0.0048 17.3 0.1 2.6 1 1 1 2 2 2 1 AAA ATPase domain TIP49 PF06068.13 ELR14311.1 - 4.2e-05 22.9 0.7 8.5e-05 21.9 0.2 1.6 1 1 1 2 2 2 1 TIP49 P-loop domain RuvB_N PF05496.12 ELR14311.1 - 0.0039 16.9 0.0 0.0065 16.2 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_2 PF07724.14 ELR14311.1 - 0.0061 16.7 0.0 0.0091 16.1 0.0 1.2 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_25 PF13481.6 ELR14311.1 - 0.0064 16.1 1.1 0.061 12.9 1.4 2.2 1 1 0 1 1 1 1 AAA domain AAA_5 PF07728.14 ELR14311.1 - 0.008 16.2 0.1 0.026 14.5 0.1 2.0 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) NACHT PF05729.12 ELR14311.1 - 0.018 15.0 0.2 4 7.3 0.1 2.3 1 1 1 2 2 2 0 NACHT domain AAA_22 PF13401.6 ELR14311.1 - 0.033 14.5 0.4 0.19 12.0 0.1 2.1 1 1 1 2 2 2 0 AAA domain ABC_tran PF00005.27 ELR14311.1 - 0.039 14.5 0.0 0.066 13.7 0.0 1.4 1 0 0 1 1 1 0 ABC transporter IstB_IS21 PF01695.17 ELR14311.1 - 0.039 13.7 0.4 0.12 12.1 0.2 1.7 1 1 1 2 2 2 0 IstB-like ATP binding protein AAA_28 PF13521.6 ELR14311.1 - 0.047 13.9 0.0 0.086 13.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain Sigma54_activat PF00158.26 ELR14311.1 - 0.092 12.4 0.0 0.22 11.2 0.0 1.6 1 1 0 1 1 1 0 Sigma-54 interaction domain ATPase_2 PF01637.18 ELR14311.1 - 0.098 12.6 0.1 0.19 11.6 0.0 1.3 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea Zeta_toxin PF06414.12 ELR14311.1 - 0.1 11.9 0.0 5.1 6.3 0.0 2.2 2 0 0 2 2 2 0 Zeta toxin Hpr_kinase_C PF07475.12 ELR14311.1 - 0.16 11.5 0.0 0.31 10.5 0.0 1.4 1 0 0 1 1 1 0 HPr Serine kinase C-terminal domain AAA_14 PF13173.6 ELR14311.1 - 0.19 11.7 0.0 0.36 10.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 ELR14311.1 - 0.23 11.8 0.0 0.36 11.2 0.0 1.4 1 1 0 1 1 1 0 RNA helicase TPT PF03151.16 ELR14313.1 - 1.4e-36 126.3 22.6 1.8e-36 126.0 22.6 1.0 1 0 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 ELR14313.1 - 3.7e-10 40.1 34.1 6.3e-05 23.2 11.1 2.2 2 0 0 2 2 2 2 EamA-like transporter family UAA PF08449.11 ELR14313.1 - 3.5e-05 23.2 23.4 6.3e-05 22.3 23.4 1.5 1 1 0 1 1 1 1 UAA transporter family RNA_bind PF08675.11 ELR14313.1 - 0.13 12.3 0.1 0.24 11.4 0.1 1.4 1 0 0 1 1 1 0 RNA binding domain PH PF00169.29 ELR14314.1 - 9.9e-49 164.2 0.7 4.8e-20 72.0 0.0 3.4 3 1 0 3 3 3 3 PH domain ArfGap PF01412.18 ELR14314.1 - 1.1e-26 93.2 1.7 1.4e-25 89.6 0.7 2.4 1 1 1 2 2 2 1 Putative GTPase activating protein for Arf PH_8 PF15409.6 ELR14314.1 - 3.8e-22 78.4 0.2 1.3e-09 38.2 0.0 3.2 3 0 0 3 3 3 3 Pleckstrin homology domain PH_11 PF15413.6 ELR14314.1 - 1.4e-20 73.7 8.5 1.5e-08 35.0 0.8 5.2 3 2 0 3 3 3 3 Pleckstrin homology domain PH_3 PF14593.6 ELR14314.1 - 1.8e-10 40.9 0.0 0.00082 19.4 0.0 3.1 3 0 0 3 3 3 2 PH domain PH_9 PF15410.6 ELR14314.1 - 3.9e-07 30.5 0.4 0.01 16.2 0.2 3.4 3 1 0 3 3 3 2 Pleckstrin homology domain PH_6 PF15406.6 ELR14314.1 - 0.00011 22.4 0.1 0.45 10.8 0.0 2.8 2 0 0 2 2 2 2 Pleckstrin homology domain PH_15 PF17339.2 ELR14314.1 - 0.0015 18.4 0.3 3 7.8 0.1 3.0 3 0 0 3 3 3 2 PH domain PH_13 PF16652.5 ELR14314.1 - 0.0018 18.1 0.3 2.9 7.7 0.0 2.8 3 0 0 3 3 3 2 Pleckstrin homology domain PH_16 PF17838.1 ELR14314.1 - 0.0061 16.4 0.0 1.2 9.0 0.0 2.4 2 0 0 2 2 2 1 PH domain DUF3127 PF11325.8 ELR14314.1 - 0.016 15.4 0.2 69 3.8 0.0 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF3127) PH_2 PF08458.10 ELR14314.1 - 0.055 13.8 0.0 7.1 7.0 0.0 2.5 2 0 0 2 2 2 0 Plant pleckstrin homology-like region Peptidase_M41 PF01434.18 ELR14316.1 - 3.9e-60 203.0 0.0 6.8e-60 202.2 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M41 AAA PF00004.29 ELR14316.1 - 1.1e-41 142.4 0.0 1.9e-41 141.6 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 ELR14316.1 - 6.8e-14 51.4 0.0 1.5e-13 50.3 0.0 1.5 1 0 0 1 1 1 1 AAA+ lid domain Cation_efflux PF01545.21 ELR14316.1 - 5.7e-12 45.8 37.6 1.4e-09 37.9 2.8 3.3 3 1 1 4 4 4 2 Cation efflux family FtsH_ext PF06480.15 ELR14316.1 - 4.9e-07 30.1 0.1 3.6e-06 27.3 0.0 2.6 2 0 0 2 2 2 1 FtsH Extracellular TIP49 PF06068.13 ELR14316.1 - 0.017 14.3 0.0 0.03 13.6 0.0 1.2 1 0 0 1 1 1 0 TIP49 P-loop domain AAA_22 PF13401.6 ELR14316.1 - 0.017 15.4 0.0 0.42 10.9 0.0 2.7 1 1 0 1 1 1 0 AAA domain AAA_5 PF07728.14 ELR14316.1 - 0.017 15.1 0.0 0.049 13.6 0.0 1.8 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) RuvB_N PF05496.12 ELR14316.1 - 0.027 14.2 0.0 0.057 13.2 0.0 1.4 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 ELR14316.1 - 0.079 13.3 1.8 0.21 12.0 0.2 2.4 2 1 1 3 3 3 0 AAA ATPase domain AAA_33 PF13671.6 ELR14316.1 - 0.15 12.2 0.0 0.54 10.4 0.0 2.0 2 0 0 2 2 1 0 AAA domain Mg_chelatase PF01078.21 ELR14316.1 - 0.16 11.4 0.3 0.36 10.2 0.3 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI RasGEF PF00617.19 ELR14317.1 - 1.6e-79 266.2 0.9 5.3e-50 170.1 0.1 2.7 2 0 0 2 2 2 2 RasGEF domain RasGEF_N PF00618.20 ELR14317.1 - 3.9e-53 178.1 2.3 1.7e-26 92.5 1.0 2.6 2 0 0 2 2 2 2 RasGEF N-terminal motif JIP_LZII PF16471.5 ELR14317.1 - 0.087 13.0 0.3 0.35 11.1 0.3 2.0 1 0 0 1 1 1 0 JNK-interacting protein leucine zipper II DUF1192 PF06698.11 ELR14317.1 - 0.22 11.6 1.2 4.2 7.5 0.0 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1192) NUDIX PF00293.28 ELR14319.1 - 0.0007 19.7 4.3 0.0095 16.0 2.1 2.6 1 1 1 2 2 2 2 NUDIX domain UQ_con PF00179.26 ELR14320.1 - 6.2e-23 81.0 0.0 1.1e-22 80.2 0.0 1.4 1 1 0 1 1 1 1 Ubiquitin-conjugating enzyme UFC1 PF08694.11 ELR14320.1 - 0.001 18.7 0.0 0.0025 17.4 0.0 1.6 2 0 0 2 2 2 1 Ubiquitin-fold modifier-conjugating enzyme 1 RhoGEF PF00621.20 ELR14321.1 - 6.4e-52 176.4 0.5 1.1e-51 175.7 0.5 1.4 1 0 0 1 1 1 1 RhoGEF domain F-box-like PF12937.7 ELR14321.1 - 8.9e-05 22.3 0.1 0.00017 21.4 0.1 1.5 1 0 0 1 1 1 1 F-box-like PH PF00169.29 ELR14321.1 - 0.00068 20.1 0.1 0.0022 18.5 0.1 1.9 1 0 0 1 1 1 1 PH domain F-box PF00646.33 ELR14321.1 - 0.12 12.3 0.0 0.25 11.2 0.0 1.5 1 0 0 1 1 1 0 F-box domain AGH PF17558.2 ELR14321.1 - 2.5 8.3 4.8 6.4 7.0 4.8 1.7 1 0 0 1 1 1 0 Androgenic gland hormone RhoGEF PF00621.20 ELR14322.1 - 2.3e-24 86.6 0.0 5.2e-24 85.5 0.0 1.6 1 0 0 1 1 1 1 RhoGEF domain PH PF00169.29 ELR14322.1 - 0.001 19.6 0.1 0.008 16.7 0.3 2.2 2 0 0 2 2 2 1 PH domain SH3_9 PF14604.6 ELR14322.1 - 0.021 14.7 0.0 0.042 13.7 0.0 1.5 1 0 0 1 1 1 0 Variant SH3 domain SH3_1 PF00018.28 ELR14322.1 - 0.091 12.4 0.0 0.18 11.5 0.0 1.5 1 0 0 1 1 1 0 SH3 domain Pox_VP8_L4R PF04498.12 ELR14322.1 - 0.14 11.8 0.0 0.22 11.1 0.0 1.2 1 0 0 1 1 1 0 Poxvirus nucleic acid binding protein VP8/L4R Metallophos PF00149.28 ELR14323.1 - 1.5e-19 71.3 3.6 2.2e-19 70.8 3.6 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Pur_ac_phosph_N PF16656.5 ELR14323.1 - 6.9e-16 58.6 0.6 6.9e-16 58.6 0.6 2.2 2 0 0 2 2 2 1 Purple acid Phosphatase, N-terminal domain Metallophos_C PF14008.6 ELR14323.1 - 2.4e-15 57.2 0.1 9.5e-15 55.2 0.1 2.1 1 0 0 1 1 1 1 Iron/zinc purple acid phosphatase-like protein C Metallophos_2 PF12850.7 ELR14323.1 - 0.035 14.3 0.0 0.25 11.5 0.0 2.0 1 1 0 1 1 1 0 Calcineurin-like phosphoesterase superfamily domain PhoD PF09423.10 ELR14323.1 - 0.055 12.5 0.0 4.4 6.2 0.0 2.1 2 0 0 2 2 2 0 PhoD-like phosphatase PB1 PF00564.24 ELR14324.1 - 3.6e-08 33.2 0.0 1.1e-07 31.7 0.0 1.9 2 0 0 2 2 2 1 PB1 domain PIN_9 PF18477.1 ELR14324.1 - 0.06 13.7 0.0 0.2 12.0 0.0 1.8 1 0 0 1 1 1 0 PIN like domain DUF4081 PF13312.6 ELR14324.1 - 0.084 13.1 0.9 0.23 11.6 0.9 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4081) SUIM_assoc PF16619.5 ELR14325.1 - 0.00057 19.9 0.1 0.0048 16.9 0.0 2.5 2 1 0 2 2 2 1 Unstructured region C-term to UIM in Ataxin3 GHMP_kinases_C PF08544.13 ELR14327.1 - 4.6e-08 33.3 0.3 1.7e-07 31.5 0.3 2.0 1 0 0 1 1 1 1 GHMP kinases C terminal GalKase_gal_bdg PF10509.9 ELR14327.1 - 1.1e-06 28.1 0.1 2.1e-06 27.2 0.1 1.5 1 0 0 1 1 1 1 Galactokinase galactose-binding signature GHMP_kinases_N PF00288.26 ELR14327.1 - 0.00032 20.9 0.7 0.0014 18.9 0.7 2.0 1 0 0 1 1 1 1 GHMP kinases N terminal domain CDI PF02234.19 ELR14328.1 - 8.9e-07 29.0 0.0 1.8e-06 28.1 0.0 1.5 1 0 0 1 1 1 1 Cyclin-dependent kinase inhibitor RhoGEF PF00621.20 ELR14330.1 - 1.7e-36 126.1 1.3 1.7e-36 126.1 1.3 1.7 2 0 0 2 2 2 1 RhoGEF domain zf-C2H2_aberr PF17017.5 ELR14330.1 - 0.066 13.3 1.7 0.31 11.2 0.0 2.2 2 0 0 2 2 2 0 Aberrant zinc-finger C2 PF00168.30 ELR14331.1 - 1.4e-14 54.2 0.0 3.1e-14 53.1 0.0 1.6 1 0 0 1 1 1 1 C2 domain zf-UBP PF02148.19 ELR14332.1 - 3.7e-13 49.6 4.3 8.3e-13 48.5 4.3 1.6 1 1 0 1 1 1 1 Zn-finger in ubiquitin-hydrolases and other protein Mito_carr PF00153.27 ELR14334.1 - 3.6e-67 222.3 0.1 4.7e-22 77.7 0.0 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein EF-hand_7 PF13499.6 ELR14334.1 - 3.4e-07 30.6 0.1 0.00035 21.0 0.0 2.4 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 ELR14334.1 - 1.3e-05 24.4 0.4 0.37 10.5 0.0 3.2 2 1 1 3 3 3 2 EF hand EF-hand_6 PF13405.6 ELR14334.1 - 7.6e-05 22.3 0.2 0.0063 16.3 0.0 2.7 2 0 0 2 2 2 1 EF-hand domain EF-hand_8 PF13833.6 ELR14334.1 - 0.00026 20.8 0.0 0.77 9.7 0.0 2.6 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_9 PF14658.6 ELR14334.1 - 0.00044 20.5 0.0 0.0034 17.7 0.0 2.2 2 0 0 2 2 2 1 EF-hand domain Fst_toxin PF13955.6 ELR14334.1 - 0.16 11.9 1.0 12 6.0 0.1 2.5 2 0 0 2 2 2 0 Toxin Fst, type I toxin-antitoxin system PLAC8 PF04749.17 ELR14336.1 - 0.00011 23.1 5.8 0.0013 19.7 5.8 2.0 1 1 0 1 1 1 1 PLAC8 family QueH PF02677.14 ELR14336.1 - 0.48 10.5 1.3 7.3 6.7 0.1 2.1 2 0 0 2 2 2 0 Epoxyqueuosine reductase QueH CaMKII_AD PF08332.10 ELR14337.1 - 1.3e-24 86.8 0.0 1.5e-24 86.6 0.0 1.0 1 0 0 1 1 1 1 Calcium/calmodulin dependent protein kinase II association domain DUF4440 PF14534.6 ELR14337.1 - 5.4e-05 23.5 0.0 6.1e-05 23.4 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4440) SnoaL_3 PF13474.6 ELR14337.1 - 0.00022 21.5 0.0 0.00029 21.1 0.0 1.2 1 0 0 1 1 1 1 SnoaL-like domain Translin PF01997.16 ELR14338.1 - 2.9e-42 145.0 0.0 3.4e-42 144.8 0.0 1.1 1 0 0 1 1 1 1 Translin family BCS1_N PF08740.11 ELR14339.1 - 5.1e-47 160.3 0.1 7.6e-47 159.7 0.1 1.3 1 0 0 1 1 1 1 BCS1 N terminal AAA PF00004.29 ELR14339.1 - 7.7e-18 65.2 0.0 1.3e-17 64.4 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 ELR14339.1 - 4e-05 23.6 0.0 8e-05 22.7 0.0 1.5 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 ELR14339.1 - 0.00015 22.2 0.1 0.0078 16.6 0.0 2.4 1 1 1 2 2 2 1 AAA ATPase domain RNA_helicase PF00910.22 ELR14339.1 - 0.0057 17.0 0.0 0.015 15.7 0.0 1.8 1 0 0 1 1 1 1 RNA helicase AAA_33 PF13671.6 ELR14339.1 - 0.0063 16.7 0.0 0.033 14.4 0.0 2.2 2 1 0 2 2 2 1 AAA domain AAA_29 PF13555.6 ELR14339.1 - 0.0096 15.6 0.0 0.032 14.0 0.0 1.8 2 0 0 2 2 1 1 P-loop containing region of AAA domain AAA_24 PF13479.6 ELR14339.1 - 0.015 15.0 0.0 0.027 14.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 ELR14339.1 - 0.04 14.4 0.0 0.064 13.8 0.0 1.4 1 0 0 1 1 1 0 ABC transporter AAA_18 PF13238.6 ELR14339.1 - 0.056 14.0 0.0 0.1 13.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain DUF815 PF05673.13 ELR14339.1 - 0.069 12.3 0.0 0.13 11.5 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_7 PF12775.7 ELR14339.1 - 0.07 12.6 0.0 0.12 11.9 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region MMR_HSR1 PF01926.23 ELR14339.1 - 0.081 13.0 0.0 0.17 12.0 0.0 1.5 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_25 PF13481.6 ELR14339.1 - 0.14 11.7 0.0 0.51 9.9 0.0 2.0 2 1 0 2 2 2 0 AAA domain AAA_11 PF13086.6 ELR14339.1 - 0.14 11.9 0.0 0.21 11.4 0.0 1.2 1 0 0 1 1 1 0 AAA domain Aminotran_3 PF00202.21 ELR14340.1 - 2.2e-123 411.9 0.1 7.8e-122 406.8 0.1 2.0 1 1 0 1 1 1 1 Aminotransferase class-III Beta_elim_lyase PF01212.21 ELR14340.1 - 0.021 14.1 0.1 0.071 12.4 0.0 1.8 2 0 0 2 2 2 0 Beta-eliminating lyase EF-hand_7 PF13499.6 ELR14341.1 - 0.00047 20.6 0.0 1.2 9.6 0.0 2.5 1 1 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 ELR14341.1 - 0.0011 18.4 2.5 0.26 10.9 0.3 2.7 2 0 0 2 2 2 2 EF hand EF-hand_1 PF00036.32 ELR14341.1 - 0.0023 17.3 0.8 2 8.2 0.0 2.9 3 0 0 3 3 3 2 EF hand Dockerin_1 PF00404.18 ELR14341.1 - 0.022 15.0 0.0 0.44 10.8 0.0 2.5 3 0 0 3 3 3 0 Dockerin type I domain VCBS PF13517.6 ELR14341.1 - 0.023 15.3 0.0 11 6.7 0.0 2.4 2 1 0 2 2 2 0 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella EF-hand_6 PF13405.6 ELR14341.1 - 0.023 14.6 0.9 5.4 7.2 0.1 2.9 2 0 0 2 2 2 0 EF-hand domain FG-GAP PF01839.23 ELR14341.1 - 0.21 11.7 2.5 17 5.7 0.0 2.5 2 0 0 2 2 2 0 FG-GAP repeat Exo_endo_phos PF03372.23 ELR14342.1 - 2.1e-18 66.7 0.0 5.5e-18 65.3 0.0 1.7 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family FSA_C PF10479.9 ELR14342.1 - 0.35 9.0 4.0 0.46 8.5 4.0 1.1 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus DUF3439 PF11921.8 ELR14342.1 - 1.6 8.7 13.2 3.1 7.8 13.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) Mucin PF01456.17 ELR14342.1 - 6.2 6.8 20.6 9.2 6.3 20.6 1.2 1 0 0 1 1 1 0 Mucin-like glycoprotein HATPase_c PF02518.26 ELR14343.1 - 1.4e-28 99.7 0.4 2.9e-28 98.6 0.4 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 ELR14343.1 - 5.3e-24 84.6 0.1 2.8e-21 75.8 0.1 3.0 3 0 0 3 3 3 2 Response regulator receiver domain HisKA PF00512.25 ELR14343.1 - 6e-20 71.0 0.0 2.2e-19 69.2 0.0 2.1 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain HATPase_c_3 PF13589.6 ELR14343.1 - 0.0014 18.4 0.0 0.0035 17.2 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Pkinase_C PF00433.24 ELR14345.1 - 3.3e-07 30.9 0.1 5.3e-07 30.2 0.1 1.4 1 0 0 1 1 1 1 Protein kinase C terminal domain EF-hand_7 PF13499.6 ELR14347.1 - 1e-12 48.3 6.3 1.5e-07 31.7 0.3 1.8 1 1 2 3 3 3 3 EF-hand domain pair EF-hand_1 PF00036.32 ELR14347.1 - 2.8e-10 39.0 0.4 1.6e-05 24.1 0.1 2.5 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 ELR14347.1 - 8.6e-09 34.6 0.5 0.00099 18.9 0.0 2.4 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.6 ELR14347.1 - 3e-08 33.4 0.2 0.00021 21.1 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 ELR14347.1 - 8.5e-08 31.4 5.1 0.00051 19.4 0.1 2.9 3 1 0 3 3 3 2 EF hand UPF0223 PF05256.12 ELR14347.1 - 0.024 15.0 0.1 0.051 13.9 0.1 1.4 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0223) p25-alpha PF05517.12 ELR14347.1 - 0.11 12.7 0.2 0.61 10.2 0.4 1.8 1 1 1 2 2 2 0 p25-alpha MgtE_N PF03448.17 ELR14347.1 - 0.11 13.1 0.8 0.32 11.6 0.4 2.0 1 1 0 1 1 1 0 MgtE intracellular N domain PRP3 PF08572.10 ELR14348.1 - 0.037 13.8 9.9 0.061 13.0 9.9 1.4 1 1 0 1 1 1 0 pre-mRNA processing factor 3 (PRP3) Leucyl-specific PF14795.6 ELR14348.1 - 0.17 12.0 3.1 0.17 12.0 0.9 2.1 2 0 0 2 2 2 0 Leucine-tRNA synthetase-specific domain Aminotran_3 PF00202.21 ELR14352.1 - 2e-14 53.1 0.0 2.4e-14 52.8 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-III DUF3081 PF11280.8 ELR14355.1 - 0.14 12.0 0.0 0.21 11.4 0.0 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3081) PNK3P PF08645.11 ELR14356.1 - 4.5e-55 185.8 0.0 1.1e-54 184.6 0.0 1.6 1 0 0 1 1 1 1 Polynucleotide kinase 3 phosphatase AAA_33 PF13671.6 ELR14356.1 - 4.2e-18 65.9 0.0 1.7e-15 57.5 0.0 2.8 2 1 0 2 2 2 1 AAA domain zf-CCHH PF10283.9 ELR14356.1 - 1.2e-11 44.4 0.2 2.8e-11 43.2 0.2 1.6 1 0 0 1 1 1 1 PBZ domain Zeta_toxin PF06414.12 ELR14356.1 - 5.4e-05 22.6 0.0 0.041 13.2 0.0 2.3 2 0 0 2 2 2 2 Zeta toxin KTI12 PF08433.10 ELR14356.1 - 7.4e-05 22.3 0.0 0.04 13.4 0.0 2.2 2 0 0 2 2 2 2 Chromatin associated protein KTI12 Hydrolase_6 PF13344.6 ELR14356.1 - 0.019 15.0 0.0 0.26 11.4 0.0 2.4 2 0 0 2 2 2 0 Haloacid dehalogenase-like hydrolase SET PF00856.28 ELR14357.1 - 5.9e-18 65.8 0.0 2.6e-17 63.7 0.0 1.9 1 1 0 1 1 1 1 SET domain zf-MYND PF01753.18 ELR14357.1 - 0.00085 19.4 10.7 0.00085 19.4 10.7 2.2 2 0 0 2 2 2 1 MYND finger zinc_ribbon_9 PF14369.6 ELR14357.1 - 8.3 6.8 12.8 0.94 9.8 1.4 3.3 3 0 0 3 3 3 0 zinc-ribbon WCCH PF03716.14 ELR14357.1 - 8.8 6.1 12.6 9.5 6.0 1.7 3.7 3 0 0 3 3 3 0 WCCH motif 2TM PF13239.6 ELR14358.1 - 0.0017 18.6 3.6 0.0017 18.6 3.6 4.1 2 2 2 4 4 4 2 2TM domain DZR PF12773.7 ELR14358.1 - 0.0034 17.4 1.5 0.0055 16.7 1.5 1.3 1 0 0 1 1 1 1 Double zinc ribbon zf-RanBP PF00641.18 ELR14358.1 - 0.065 12.6 4.2 0.1 11.9 4.2 1.3 1 0 0 1 1 1 0 Zn-finger in Ran binding protein and others zinc_ribbon_2 PF13240.6 ELR14358.1 - 0.65 9.8 6.1 1.1 9.0 6.1 1.4 1 0 0 1 1 1 0 zinc-ribbon domain DUF2101 PF09874.9 ELR14358.1 - 1.2 8.8 7.8 1.3 8.6 3.6 2.1 1 1 1 2 2 2 0 Predicted membrane protein (DUF2101) Spore_YhaL PF14147.6 ELR14358.1 - 3.4 7.4 5.9 3.4 7.4 0.2 2.6 2 0 0 2 2 2 0 Sporulation protein YhaL DUF3792 PF12670.7 ELR14358.1 - 4.7 7.4 5.7 6.4 7.0 1.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3792) zinc_ribbon_15 PF17032.5 ELR14358.1 - 5.3 7.9 7.5 0.76 10.6 2.3 2.0 2 0 0 2 2 2 0 zinc-ribbon family MMR_HSR1_Xtn PF16897.5 ELR14359.1 - 2.6e-37 127.1 0.1 5.2e-37 126.1 0.1 1.5 1 0 0 1 1 1 1 C-terminal region of MMR_HSR1 domain TGS PF02824.21 ELR14359.1 - 1.1e-20 73.4 0.0 1.9e-20 72.6 0.0 1.4 1 0 0 1 1 1 1 TGS domain MMR_HSR1 PF01926.23 ELR14359.1 - 6.5e-20 71.3 0.0 1.3e-19 70.3 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 ELR14359.1 - 2e-09 37.2 0.0 3.5e-09 36.4 0.0 1.4 1 0 0 1 1 1 1 Ferrous iron transport protein B Dynamin_N PF00350.23 ELR14359.1 - 0.0044 17.1 0.1 0.07 13.2 0.0 2.2 1 1 1 2 2 2 1 Dynamin family SMI1_KNR4 PF09346.10 ELR14362.1 - 2.7e-06 27.8 0.0 7.4e-06 26.4 0.0 1.7 2 0 0 2 2 2 1 SMI1 / KNR4 family (SUKH-1) SUKH_5 PF14567.6 ELR14362.1 - 0.006 16.3 0.0 0.012 15.4 0.0 1.5 1 0 0 1 1 1 1 SMI1-KNR4 cell-wall Ank_2 PF12796.7 ELR14363.1 - 3.2e-09 37.2 0.2 5.7e-09 36.4 0.2 1.4 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) F-box-like PF12937.7 ELR14363.1 - 1.5e-07 31.1 0.0 2.9e-07 30.3 0.0 1.5 1 0 0 1 1 1 1 F-box-like Ank_4 PF13637.6 ELR14363.1 - 2.7e-06 27.8 0.4 0.00016 22.2 0.1 2.5 1 1 2 3 3 3 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 ELR14363.1 - 4.7e-06 26.8 3.7 0.0016 18.7 0.4 3.7 1 1 2 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.30 ELR14363.1 - 2.9e-05 24.3 0.5 0.21 12.1 0.2 3.4 3 0 0 3 3 3 2 Ankyrin repeat Ank_3 PF13606.6 ELR14363.1 - 0.00036 20.8 0.8 11 7.0 0.0 3.6 3 0 0 3 3 3 1 Ankyrin repeat F-box PF00646.33 ELR14363.1 - 0.13 12.2 0.1 0.42 10.6 0.1 1.8 1 1 0 1 1 1 0 F-box domain RRM_1 PF00076.22 ELR14364.1 - 2.1e-06 27.4 0.2 6.3e-06 25.9 0.2 1.7 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) XRN_M PF17846.1 ELR14365.1 - 3.6e-110 368.9 4.2 8.5e-110 367.7 4.2 1.6 1 0 0 1 1 1 1 Xrn1 helical domain XRN_N PF03159.18 ELR14365.1 - 7.6e-82 274.4 0.4 7.6e-82 274.4 0.4 1.7 2 0 0 2 2 2 1 XRN 5'-3' exonuclease N-terminus XRN1_D1 PF18332.1 ELR14365.1 - 7.4e-35 120.5 2.4 6.1e-23 81.6 0.1 3.0 2 1 1 3 3 3 2 Exoribonuclease Xrn1 D1 domain SH3_12 PF18129.1 ELR14365.1 - 3e-22 78.5 0.2 8.9e-20 70.6 0.1 2.5 2 0 0 2 2 2 2 Xrn1 SH3-like domain Xrn1_D3 PF18194.1 ELR14365.1 - 0.0011 19.0 0.1 0.003 17.6 0.1 1.7 1 0 0 1 1 1 1 Exoribonuclease 1 Domain-3 Mating_C PF12737.7 ELR14365.1 - 0.25 10.5 3.9 0.56 9.4 3.9 1.5 1 0 0 1 1 1 0 C-terminal domain of homeodomain 1 Ank_5 PF13857.6 ELR14366.1 - 2.3e-14 53.2 9.5 3.5 8.0 0.0 10.0 9 1 2 11 11 11 5 Ankyrin repeats (many copies) Ank_4 PF13637.6 ELR14366.1 - 6.7e-14 52.1 14.1 0.19 12.3 0.1 8.9 1 1 10 11 11 11 10 Ankyrin repeats (many copies) Ank_2 PF12796.7 ELR14366.1 - 4.9e-09 36.7 2.0 0.26 11.9 0.0 5.0 1 1 5 6 6 6 5 Ankyrin repeats (3 copies) CXCXC PF03128.14 ELR14366.1 - 0.045 14.2 38.5 9.8 6.9 0.6 9.0 9 0 0 9 9 9 0 CXCXC repeat DUF3400 PF11880.8 ELR14366.1 - 0.15 11.6 1.3 19 4.9 0.0 4.6 6 0 0 6 6 6 0 Domain of unknown function (DUF3400) ABC2_membrane PF01061.24 ELR14368.1 - 1.1e-34 119.8 16.3 1.6e-34 119.2 16.3 1.3 1 0 0 1 1 1 1 ABC-2 type transporter ABC_tran PF00005.27 ELR14368.1 - 1.7e-27 96.6 0.1 3.1e-27 95.8 0.1 1.4 1 0 0 1 1 1 1 ABC transporter ABC2_membrane_3 PF12698.7 ELR14368.1 - 5.2e-06 25.8 12.1 5.2e-06 25.8 12.1 1.7 1 1 0 1 1 1 1 ABC-2 family transporter protein T2SSE PF00437.20 ELR14368.1 - 9.8e-06 24.8 1.5 0.0006 18.9 0.3 2.2 2 0 0 2 2 2 1 Type II/IV secretion system protein AAA_25 PF13481.6 ELR14368.1 - 1.4e-05 24.8 0.0 2.5e-05 23.9 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 ELR14368.1 - 0.00036 20.9 0.0 0.00069 20.0 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain AAA_30 PF13604.6 ELR14368.1 - 0.0036 17.1 0.1 0.0063 16.2 0.1 1.4 1 0 0 1 1 1 1 AAA domain AAA_21 PF13304.6 ELR14368.1 - 0.0053 16.6 0.1 1 9.1 0.2 2.5 3 0 0 3 3 3 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 ELR14368.1 - 0.0057 17.2 0.6 0.018 15.6 0.4 1.7 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.6 ELR14368.1 - 0.0066 17.0 0.0 0.012 16.2 0.0 1.4 1 0 0 1 1 1 1 AAA domain NACHT PF05729.12 ELR14368.1 - 0.0083 16.1 0.3 0.025 14.5 0.2 1.9 1 1 1 2 2 2 1 NACHT domain RsgA_GTPase PF03193.16 ELR14368.1 - 0.0084 16.0 0.1 0.017 15.0 0.1 1.5 1 0 0 1 1 1 1 RsgA GTPase Rad17 PF03215.15 ELR14368.1 - 0.021 14.7 0.0 0.037 14.0 0.0 1.3 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_5 PF07728.14 ELR14368.1 - 0.023 14.7 0.1 0.056 13.4 0.1 1.6 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_29 PF13555.6 ELR14368.1 - 0.027 14.2 0.1 0.063 13.0 0.1 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain MMR_HSR1 PF01926.23 ELR14368.1 - 0.035 14.2 0.2 0.088 12.9 0.2 1.7 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_22 PF13401.6 ELR14368.1 - 0.037 14.3 0.0 0.072 13.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain SMC_N PF02463.19 ELR14368.1 - 0.038 13.4 0.0 0.085 12.3 0.0 1.5 1 1 0 1 1 1 0 RecF/RecN/SMC N terminal domain DUF87 PF01935.17 ELR14368.1 - 0.042 13.9 0.9 0.071 13.2 0.9 1.3 1 0 0 1 1 1 0 Helicase HerA, central domain cobW PF02492.19 ELR14368.1 - 0.073 12.7 0.3 0.15 11.6 0.3 1.5 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA_28 PF13521.6 ELR14368.1 - 0.075 13.3 0.7 0.16 12.2 0.7 1.5 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 ELR14368.1 - 0.11 12.6 0.0 0.31 11.2 0.0 1.8 1 0 0 1 1 1 0 AAA domain dNK PF01712.19 ELR14368.1 - 0.12 12.2 0.0 0.19 11.6 0.0 1.3 1 0 0 1 1 1 0 Deoxynucleoside kinase RNA_helicase PF00910.22 ELR14368.1 - 0.14 12.6 0.0 0.36 11.2 0.0 1.8 2 0 0 2 2 1 0 RNA helicase AAA_19 PF13245.6 ELR14368.1 - 0.15 12.4 0.4 0.28 11.5 0.4 1.5 1 1 0 1 1 1 0 AAA domain Ras PF00071.22 ELR14370.1 - 0.00023 20.8 0.0 0.0004 20.0 0.0 1.3 1 0 0 1 1 1 1 Ras family NosD PF05048.13 ELR14370.1 - 0.072 12.3 0.2 0.096 11.9 0.2 1.3 1 1 0 1 1 1 0 Periplasmic copper-binding protein (NosD) adh_short_C2 PF13561.6 ELR14372.1 - 6.9e-26 91.2 0.1 7.5e-26 91.1 0.1 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 ELR14372.1 - 3.9e-17 62.3 0.0 4.6e-17 62.1 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase LRR_8 PF13855.6 ELR14373.1 - 2.4e-15 56.0 15.7 2.8e-09 36.6 5.0 3.8 2 1 1 3 3 3 3 Leucine rich repeat LRR_4 PF12799.7 ELR14373.1 - 1.7e-09 37.8 16.6 1.1e-05 25.7 0.5 4.5 2 1 1 4 4 4 3 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 ELR14373.1 - 9.7e-08 31.5 22.0 0.8 9.9 0.6 6.5 6 0 0 6 6 6 6 Leucine Rich repeat LRR_1 PF00560.33 ELR14373.1 - 1.7e-06 27.8 12.2 3.9 8.4 0.1 6.3 5 1 0 5 5 5 3 Leucine Rich Repeat LRR_9 PF14580.6 ELR14373.1 - 0.0019 17.7 0.4 0.0055 16.2 0.2 1.7 1 1 0 1 1 1 1 Leucine-rich repeat LRR_5 PF13306.6 ELR14373.1 - 0.0039 17.1 0.0 0.0089 16.0 0.0 1.6 1 1 0 1 1 1 1 BspA type Leucine rich repeat region (6 copies) Coilin_N PF15862.5 ELR14374.1 - 2 8.2 13.1 0.28 11.0 7.5 2.0 2 0 0 2 2 2 0 Coilin N-terminus DUF3381 PF11861.8 ELR14374.1 - 3.2 7.5 25.5 4.8 6.9 2.5 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF3381) Cytomega_UL84 PF06284.11 ELR14374.1 - 6.1 5.2 7.0 9.7 4.5 7.0 1.2 1 0 0 1 1 1 0 Cytomegalovirus UL84 protein MORN PF02493.20 ELR14376.1 - 6.4e-19 66.7 1.5 1.5e-05 24.5 0.6 4.2 4 0 0 4 4 4 4 MORN repeat DUF448 PF04296.13 ELR14376.1 - 0.13 12.1 0.1 0.51 10.2 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF448) MORN PF02493.20 ELR14377.1 - 3.9e-52 171.1 48.6 3.5e-09 36.0 0.0 11.2 11 0 0 11 11 11 10 MORN repeat B-block_TFIIIC PF04182.12 ELR14377.1 - 1.4e-08 34.7 0.4 1.5 9.0 0.0 5.7 3 3 3 6 6 6 4 B-block binding subunit of TFIIIC RabGGT_insert PF07711.11 ELR14377.1 - 1.6 9.3 3.6 18 5.9 0.1 3.7 2 2 1 4 4 4 0 Rab geranylgeranyl transferase alpha-subunit, insert domain GATA PF00320.27 ELR14379.1 - 1.6e-15 56.4 4.1 3.2e-15 55.4 4.1 1.5 1 0 0 1 1 1 1 GATA zinc finger zf-C2H2_11 PF16622.5 ELR14379.1 - 0.00042 20.0 1.8 0.18 11.6 0.4 2.4 2 0 0 2 2 2 2 zinc-finger C2H2-type Zn-ribbon_8 PF09723.10 ELR14379.1 - 0.00052 20.1 2.2 0.0039 17.3 0.4 2.3 2 0 0 2 2 2 1 Zinc ribbon domain zf-HYPF PF07503.12 ELR14379.1 - 0.16 11.8 2.1 7.8 6.4 0.1 2.3 2 0 0 2 2 2 0 HypF finger zf-C2H2_4 PF13894.6 ELR14379.1 - 0.18 12.8 1.0 4 8.5 0.3 2.6 2 0 0 2 2 2 0 C2H2-type zinc finger Nudix_N_2 PF14803.6 ELR14379.1 - 0.28 11.1 2.1 0.57 10.1 2.1 1.6 1 0 0 1 1 1 0 Nudix N-terminal WD40 PF00400.32 ELR14380.1 - 4.5e-28 96.9 13.9 0.029 15.3 0.0 11.1 9 2 0 9 9 9 7 WD domain, G-beta repeat Sulfotransfer_1 PF00685.27 ELR14380.1 - 2.9e-10 40.1 3.1 0.00015 21.3 0.3 2.6 2 0 0 2 2 2 2 Sulfotransferase domain ANAPC4_WD40 PF12894.7 ELR14380.1 - 2.2e-09 37.5 2.9 0.23 11.8 0.0 4.7 4 0 0 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Sulfotransfer_3 PF13469.6 ELR14380.1 - 3.6e-09 37.3 7.2 0.0016 18.9 0.4 3.5 3 0 0 3 3 3 2 Sulfotransferase family F-box-like PF12937.7 ELR14380.1 - 1.6e-05 24.7 0.0 6.3e-05 22.8 0.0 2.1 1 0 0 1 1 1 1 F-box-like Tachystatin_A PF11406.8 ELR14380.1 - 0.0076 16.3 0.0 9.4 6.4 0.0 2.9 2 0 0 2 2 2 2 Antimicrobial peptide tachystatin A F-box PF00646.33 ELR14380.1 - 0.009 15.9 0.1 0.025 14.4 0.1 1.7 1 0 0 1 1 1 1 F-box domain Elongin_A PF06881.11 ELR14380.1 - 0.017 15.7 0.0 0.017 15.7 0.0 3.5 4 0 0 4 4 4 0 RNA polymerase II transcription factor SIII (Elongin) subunit A DUF2039 PF10217.9 ELR14380.1 - 0.15 12.4 1.8 24 5.4 0.1 2.7 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2039) Metallophos PF00149.28 ELR14381.1 - 4.5e-10 40.4 0.0 5.8e-10 40.0 0.0 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 ELR14381.1 - 2.9e-05 24.3 0.0 0.00082 19.6 0.0 2.2 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Isochorismatase PF00857.20 ELR14382.1 - 3.1e-19 69.8 0.3 1.9e-11 44.5 0.1 2.1 2 0 0 2 2 2 2 Isochorismatase family WD40 PF00400.32 ELR14383.1 - 1.3e-18 67.0 14.1 1.7e-06 28.6 0.1 5.3 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ELR14383.1 - 2.1e-17 63.2 2.3 1.7e-10 41.0 0.1 2.6 2 0 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain IKI3 PF04762.12 ELR14383.1 - 0.0044 15.1 0.3 0.08 10.9 0.1 2.2 2 0 0 2 2 2 1 IKI3 family DPPIV_N PF00930.21 ELR14383.1 - 0.031 13.0 0.7 0.12 11.2 0.3 2.1 1 1 1 2 2 2 0 Dipeptidyl peptidase IV (DPP IV) N-terminal region Glyco_hydro_10 PF00331.20 ELR14384.1 - 4e-28 98.5 0.0 5.4e-28 98.1 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 10 EST1_DNA_bind PF10373.9 ELR14384.1 - 0.11 11.9 0.1 0.21 11.0 0.1 1.4 1 0 0 1 1 1 0 Est1 DNA/RNA binding domain SH3_9 PF14604.6 ELR14385.1 - 6.4e-21 74.0 1.6 1.2e-12 47.5 0.2 2.5 2 0 0 2 2 2 2 Variant SH3 domain SH3_2 PF07653.17 ELR14385.1 - 1.4e-19 69.6 0.4 4.7e-09 35.8 0.0 2.4 2 0 0 2 2 2 2 Variant SH3 domain SH3_1 PF00018.28 ELR14385.1 - 1.8e-19 69.1 2.7 4.5e-13 48.6 0.1 2.8 3 0 0 3 3 3 2 SH3 domain Anti-adapt_IraP PF10796.9 ELR14385.1 - 0.18 12.4 2.1 0.24 12.0 0.2 2.2 2 0 0 2 2 2 0 Sigma-S stabilisation anti-adaptor protein DUF3446 PF11928.8 ELR14385.1 - 0.75 10.1 7.0 38 4.7 0.0 2.5 2 0 0 2 2 2 0 Early growth response N-terminal domain DUF3138 PF11336.8 ELR14385.1 - 2 6.9 5.3 5 5.6 5.3 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) Alpha_kinase PF02816.18 ELR14385.1 - 2.2 8.4 5.6 5.6 7.1 5.6 1.8 1 1 0 1 1 1 0 Alpha-kinase family Cauli_AT PF03233.13 ELR14385.1 - 6.5 6.7 9.3 9.6 6.1 3.6 2.5 2 0 0 2 2 2 0 Aphid transmission protein Exo_endo_phos PF03372.23 ELR14386.1 - 6.6e-10 38.9 0.0 8.9e-10 38.5 0.0 1.1 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.6 ELR14386.1 - 0.004 17.0 0.0 0.0064 16.3 0.0 1.4 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase WD40 PF00400.32 ELR14387.1 - 9.3e-13 48.5 11.7 0.0022 18.8 0.0 5.7 5 1 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ELR14387.1 - 4.4e-08 33.3 1.3 0.0018 18.5 0.1 3.5 2 1 1 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 ELR14387.1 - 0.0014 18.6 0.1 0.0024 17.8 0.1 1.5 1 0 0 1 1 1 1 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 ELR14387.1 - 0.013 14.5 1.1 0.41 9.6 0.4 3.2 1 1 1 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein DUF4652 PF15525.6 ELR14387.1 - 0.63 9.8 1.8 2 8.1 0.1 2.3 2 1 1 3 3 3 0 Domain of unknown function (DUF4652) LRR_4 PF12799.7 ELR14389.1 - 2.4e-05 24.6 5.8 0.88 10.1 0.3 5.6 5 0 0 5 5 5 2 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 ELR14389.1 - 0.00048 20.0 6.8 0.81 9.9 0.0 6.4 8 0 0 8 8 8 2 Leucine Rich repeat IQ PF00612.27 ELR14389.1 - 0.2 11.6 2.0 0.69 9.9 2.0 1.9 1 0 0 1 1 1 0 IQ calmodulin-binding motif LRR_1 PF00560.33 ELR14389.1 - 0.56 11.0 4.1 27 5.8 0.0 5.5 6 2 0 6 6 6 0 Leucine Rich Repeat Bactofilin PF04519.13 ELR14390.1 - 0.01 16.1 0.5 0.11 12.8 0.3 2.1 1 1 1 2 2 2 0 Polymer-forming cytoskeletal RabGAP-TBC PF00566.18 ELR14392.1 - 4e-40 137.8 0.1 2e-34 119.2 0.0 2.3 1 1 1 2 2 2 2 Rab-GTPase-TBC domain ORC6 PF05460.13 ELR14392.1 - 0.17 11.1 5.8 0.43 9.8 5.8 1.6 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) Macoilin PF09726.9 ELR14392.1 - 0.83 8.1 3.1 2.1 6.8 3.1 1.6 1 0 0 1 1 1 0 Macoilin family CMV_1a PF12467.8 ELR14392.1 - 2.6 8.4 9.2 5.8 7.2 9.2 1.5 1 0 0 1 1 1 0 Cucumber mosaic virus 1a protein family GAF_2 PF13185.6 ELR14392.1 - 4.6 7.6 6.0 24 5.2 0.0 3.9 4 1 0 4 4 4 0 GAF domain Tim17 PF02466.19 ELR14393.1 - 5.7e-16 58.9 7.8 8e-16 58.4 7.8 1.2 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family Peroxin-3 PF04882.12 ELR14394.1 - 0.037 13.0 1.9 0.068 12.2 1.9 1.3 1 0 0 1 1 1 0 Peroxin-3 Serglycin PF04360.12 ELR14395.1 - 0.22 11.5 2.1 0.63 10.0 2.1 1.7 1 0 0 1 1 1 0 Serglycin PRK PF00485.18 ELR14396.1 - 1.7e-05 24.7 0.0 2.2e-05 24.3 0.0 1.1 1 0 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family PRK PF00485.18 ELR14397.1 - 4.3e-05 23.4 0.0 5.9e-05 22.9 0.0 1.2 1 0 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family Smr PF01713.21 ELR14398.1 - 3.4e-13 49.8 0.0 1.2e-12 48.0 0.0 2.1 1 0 0 1 1 1 1 Smr domain DUF1771 PF08590.10 ELR14398.1 - 4.1e-05 23.9 0.8 4.1e-05 23.9 0.8 3.0 2 0 0 2 2 2 1 Domain of unknown function (DUF1771) zf-CCCH_4 PF18044.1 ELR14398.1 - 0.00058 19.6 10.9 0.0026 17.5 0.5 2.6 2 1 0 2 2 2 2 CCCH-type zinc finger zf_CCCH_4 PF18345.1 ELR14398.1 - 0.00087 19.3 1.1 0.00087 19.3 1.1 3.1 3 0 0 3 3 3 1 Zinc finger domain zf-CCCH_3 PF15663.5 ELR14398.1 - 0.0023 18.1 5.9 0.48 10.7 0.4 2.5 1 1 1 2 2 2 2 Zinc-finger containing family CUE PF02845.16 ELR14398.1 - 0.02 14.6 0.3 0.059 13.1 0.3 1.9 1 0 0 1 1 1 0 CUE domain zf-CCCH_2 PF14608.6 ELR14398.1 - 0.15 12.6 9.1 1.3 9.6 0.3 2.3 2 0 0 2 2 2 0 RNA-binding, Nab2-type zinc finger Aminotran_5 PF00266.19 ELR14399.1 - 7.9e-15 54.7 0.0 1.2e-14 54.1 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class-V DUF2070 PF09843.9 ELR14400.1 - 4.8 5.4 8.0 6.1 5.0 8.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) DUF4956 PF16316.5 ELR14400.1 - 6.5 6.4 8.8 2.8 7.6 6.1 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4956) TPR_19 PF14559.6 ELR14401.1 - 0.087 13.3 7.4 1.5 9.4 1.2 4.5 4 1 1 5 5 5 0 Tetratricopeptide repeat TPR_2 PF07719.17 ELR14401.1 - 0.089 13.0 3.9 6.8 7.1 0.2 4.1 3 0 0 3 3 3 0 Tetratricopeptide repeat Clat_adaptor_s PF01217.20 ELR14403.1 - 5.8e-54 181.9 0.9 6.4e-54 181.8 0.9 1.0 1 0 0 1 1 1 1 Clathrin adaptor complex small chain Ribosomal_L11 PF00298.19 ELR14404.1 - 2.7e-07 31.0 0.0 5.5e-07 30.0 0.0 1.5 1 0 0 1 1 1 1 Ribosomal protein L11, RNA binding domain tRNA_bind PF01588.20 ELR14405.1 - 2.7e-27 94.7 0.1 4.4e-27 94.0 0.1 1.4 1 0 0 1 1 1 1 Putative tRNA binding domain SKA1 PF07160.12 ELR14405.1 - 0.027 14.3 2.3 0.036 13.9 2.3 1.2 1 0 0 1 1 1 0 Spindle and kinetochore-associated protein 1 ORC2 PF04084.14 ELR14405.1 - 0.037 13.0 1.3 0.21 10.5 1.3 1.9 1 1 0 1 1 1 0 Origin recognition complex subunit 2 MRFAP1 PF15155.6 ELR14405.1 - 0.19 12.3 2.2 0.36 11.3 2.2 1.4 1 0 0 1 1 1 0 MORF4 family-associated protein1 Ndc1_Nup PF09531.10 ELR14405.1 - 0.29 9.8 1.2 0.33 9.6 1.2 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup DUF3987 PF13148.6 ELR14405.1 - 2.6 7.0 6.5 3.6 6.5 6.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3987) DUF563 PF04577.14 ELR14407.1 - 4e-11 43.5 0.0 7.7e-11 42.5 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF563) GRAM PF02893.20 ELR14408.1 - 1.1e-17 63.9 0.0 2.1e-17 63.0 0.0 1.4 1 0 0 1 1 1 1 GRAM domain Coilin_N PF15862.5 ELR14408.1 - 9.3e-05 22.3 0.0 9.3e-05 22.3 0.0 3.6 1 1 2 3 3 3 1 Coilin N-terminus Vps36_ESCRT-II PF11605.8 ELR14408.1 - 0.024 14.8 0.0 0.048 13.8 0.0 1.5 1 0 0 1 1 1 0 Vacuolar protein sorting protein 36 Vps36 GREB1 PF15782.5 ELR14408.1 - 0.097 9.8 28.7 0.12 9.5 28.7 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer TFIIF_alpha PF05793.12 ELR14408.1 - 0.12 10.9 43.6 0.18 10.4 43.6 1.2 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Dapper PF15268.6 ELR14408.1 - 2.4 6.9 40.7 3 6.6 40.7 1.1 1 0 0 1 1 1 0 Dapper Hamartin PF04388.12 ELR14408.1 - 2.5 6.7 30.9 3 6.4 30.9 1.0 1 0 0 1 1 1 0 Hamartin protein Pantoate_ligase PF02569.15 ELR14409.1 - 1.7e-89 299.6 0.0 1.9e-89 299.4 0.0 1.0 1 0 0 1 1 1 1 Pantoate-beta-alanine ligase MFS_1 PF07690.16 ELR14410.1 - 7.2e-22 77.8 67.3 8.6e-16 57.8 41.9 2.4 1 1 1 2 2 2 2 Major Facilitator Superfamily OATP PF03137.20 ELR14410.1 - 0.033 12.5 7.0 0.01 14.2 2.2 2.1 2 0 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family LacY_symp PF01306.19 ELR14410.1 - 8.9 5.0 17.8 1.5 7.5 4.1 2.6 3 0 0 3 3 3 0 LacY proton/sugar symporter RUN PF02759.19 ELR14412.1 - 1.6e-16 60.5 0.9 3.5e-16 59.4 0.0 2.1 2 0 0 2 2 2 1 RUN domain PH PF00169.29 ELR14412.1 - 9.2e-06 26.1 0.0 2.6e-05 24.7 0.0 1.8 1 0 0 1 1 1 1 PH domain Lipase_GDSL PF00657.22 ELR14414.1 - 2.6e-08 34.1 0.0 3.7e-08 33.6 0.0 1.2 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Lipase_GDSL_2 PF13472.6 ELR14414.1 - 0.0028 18.1 0.1 0.008 16.6 0.1 1.8 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family SAP PF02037.27 ELR14415.1 - 1e-08 34.7 0.9 1.8e-08 33.9 0.9 1.4 1 0 0 1 1 1 1 SAP domain AAA_22 PF13401.6 ELR14415.1 - 0.069 13.4 0.1 0.12 12.7 0.1 1.3 1 0 0 1 1 1 0 AAA domain 7tm_1 PF00001.21 ELR14416.1 - 8.2e-05 22.0 11.7 0.00019 20.9 11.7 1.6 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) mRNA_stabil PF13929.6 ELR14417.1 - 0.14 11.1 0.0 0.19 10.7 0.0 1.1 1 0 0 1 1 1 0 mRNA stabilisation Nucleo_P87 PF07267.11 ELR14417.1 - 0.15 10.9 5.8 0.19 10.5 5.8 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 SRP-alpha_N PF04086.13 ELR14417.1 - 1.2 9.0 17.6 1.6 8.6 17.6 1.1 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal RR_TM4-6 PF06459.12 ELR14417.1 - 5.7 6.7 7.6 7.5 6.3 7.6 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 ADH_N_2 PF16884.5 ELR14418.1 - 2.7e-40 136.6 0.1 5.1e-40 135.7 0.1 1.4 1 0 0 1 1 1 1 N-terminal domain of oxidoreductase ADH_zinc_N PF00107.26 ELR14418.1 - 1.8e-23 82.9 0.1 2.8e-23 82.3 0.1 1.2 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 ELR14418.1 - 1.1e-11 46.0 0.0 1.7e-11 45.3 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ThrE PF06738.12 ELR14419.1 - 7.2e-47 159.8 20.8 2.6e-44 151.4 3.3 2.6 2 1 0 2 2 2 2 Putative threonine/serine exporter ThrE_2 PF12821.7 ELR14419.1 - 9.1e-05 22.6 20.7 0.0009 19.4 2.0 2.5 2 1 0 2 2 2 2 Threonine/Serine exporter, ThrE Cwf_Cwc_15 PF04889.12 ELR14419.1 - 0.028 14.2 9.4 0.059 13.1 9.4 1.5 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Ank_2 PF12796.7 ELR14420.1 - 6.6e-15 55.5 0.2 6.9e-06 26.6 0.0 2.6 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ELR14420.1 - 1.1e-12 48.2 0.1 0.00063 20.2 0.1 3.6 3 0 0 3 3 3 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 ELR14420.1 - 7.1e-10 38.9 0.1 0.013 15.8 0.1 3.7 3 0 0 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.30 ELR14420.1 - 2.7e-06 27.6 0.6 3.2 8.3 0.0 5.3 5 0 0 5 5 5 2 Ankyrin repeat Ank_3 PF13606.6 ELR14420.1 - 7.4e-06 25.9 0.4 5.6 7.9 0.1 5.1 5 0 0 5 5 5 1 Ankyrin repeat PH PF00169.29 ELR14420.1 - 0.016 15.7 0.0 0.041 14.4 0.0 1.6 1 0 0 1 1 1 0 PH domain PI3Ka PF00613.20 ELR14421.1 - 1.5e-47 161.4 0.2 3.5e-47 160.2 0.2 1.6 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) PI3_PI4_kinase PF00454.27 ELR14421.1 - 5.3e-44 150.9 0.0 7.8e-32 111.1 0.0 2.3 1 1 1 2 2 2 2 Phosphatidylinositol 3- and 4-kinase PI3K_C2 PF00792.24 ELR14421.1 - 3.8e-22 78.7 0.0 8.1e-22 77.7 0.0 1.5 1 0 0 1 1 1 1 Phosphoinositide 3-kinase C2 PI3K_rbd PF00794.18 ELR14421.1 - 2.2e-14 53.5 0.6 1.1e-11 44.8 0.0 2.4 2 0 0 2 2 2 2 PI3-kinase family, ras-binding domain DUF4135 PF13575.6 ELR14421.1 - 0.053 12.8 0.0 0.096 12.0 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4135) DUF3429 PF11911.8 ELR14423.1 - 8.6e-23 81.2 5.1 1.4e-21 77.3 5.1 2.4 1 1 0 1 1 1 1 Protein of unknown function (DUF3429) ADH_N PF08240.12 ELR14424.1 - 2.5e-09 37.0 0.0 4.1e-09 36.3 0.0 1.3 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.6 ELR14424.1 - 9.4e-05 23.5 0.1 0.00063 20.8 0.1 2.1 1 1 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.26 ELR14424.1 - 0.014 15.4 0.0 0.024 14.6 0.0 1.3 1 0 0 1 1 1 0 Zinc-binding dehydrogenase GST_N_3 PF13417.6 ELR14425.1 - 1.3e-11 44.8 0.0 2.3e-11 43.9 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.20 ELR14425.1 - 3.4e-11 43.3 0.0 1.2e-10 41.6 0.0 1.7 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 ELR14425.1 - 6.5e-10 39.2 0.0 1.4e-09 38.1 0.0 1.6 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 ELR14425.1 - 2.4e-08 34.1 0.0 3.7e-08 33.5 0.0 1.2 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 ELR14425.1 - 6.6e-07 29.5 0.0 1.1e-06 28.8 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 ELR14425.1 - 0.00085 19.3 0.3 0.0023 17.9 0.3 1.9 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Glutaredoxin PF00462.24 ELR14425.1 - 0.071 13.3 0.0 0.17 12.1 0.0 1.7 2 0 0 2 2 2 0 Glutaredoxin GST_C_5 PF16865.5 ELR14425.1 - 0.12 13.0 0.0 0.22 12.1 0.0 1.5 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain DUF2497 PF10691.9 ELR14426.1 - 0.26 11.7 3.0 0.22 11.9 0.5 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2497) PSK_trans_fac PF07704.11 ELR14428.1 - 0.57 11.0 3.4 0.45 11.3 1.1 2.0 2 1 0 2 2 2 0 Rv0623-like transcription factor Pyr_redox_2 PF07992.14 ELR14431.1 - 0.00028 20.2 0.0 0.00035 19.9 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase adh_short PF00106.25 ELR14432.1 - 7e-20 71.3 0.0 2.5e-19 69.5 0.0 1.8 2 0 0 2 2 2 1 short chain dehydrogenase PLAC8 PF04749.17 ELR14432.1 - 3.4e-17 63.3 25.7 5.9e-17 62.5 25.7 1.4 1 0 0 1 1 1 1 PLAC8 family adh_short_C2 PF13561.6 ELR14432.1 - 3.8e-13 49.5 0.0 6.8e-13 48.7 0.0 1.4 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ELR14432.1 - 0.02 14.8 0.0 0.035 14.0 0.0 1.4 1 0 0 1 1 1 0 KR domain PAT1 PF09770.9 ELR14433.1 - 5.5 5.1 10.8 6.7 4.8 10.8 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Pyr_redox_2 PF07992.14 ELR14434.1 - 3.4e-53 180.8 0.0 4e-53 180.5 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 ELR14434.1 - 1.1e-10 41.9 0.1 1.2e-09 38.6 0.1 2.5 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NYD-SP28_assoc PF14775.6 ELR14435.1 - 0.73 10.0 9.3 23 5.2 0.4 4.2 3 0 0 3 3 3 0 Sperm tail C-terminal domain DUF1664 PF07889.12 ELR14435.1 - 2.9 8.0 19.1 6.8 6.7 4.0 3.7 3 0 0 3 3 3 0 Protein of unknown function (DUF1664) Totivirus_coat PF05518.11 ELR14435.1 - 4.1 5.3 12.8 6.6 4.7 12.8 1.3 1 0 0 1 1 1 0 Totivirus coat protein DUF5570 PF17731.1 ELR14435.1 - 6.2 6.9 8.0 0.42 10.7 1.9 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF5570) Pkinase PF00069.25 ELR14436.1 - 7.8e-39 133.6 0.0 1.6e-38 132.6 0.0 1.6 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR14436.1 - 2e-37 128.9 0.2 8e-37 126.9 0.0 2.0 2 0 0 2 2 2 1 Protein tyrosine kinase Ank_2 PF12796.7 ELR14436.1 - 1e-29 102.9 0.1 9.5e-12 45.4 0.0 3.7 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ELR14436.1 - 1.1e-26 92.9 0.0 2.1e-06 28.2 0.0 5.6 1 1 4 5 5 5 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 ELR14436.1 - 4e-25 85.1 0.6 0.00016 21.8 0.0 6.5 6 0 0 6 6 6 4 Ankyrin repeat Ank PF00023.30 ELR14436.1 - 4.1e-24 83.9 1.6 0.002 18.5 0.0 6.6 7 0 0 7 7 7 5 Ankyrin repeat Ank_5 PF13857.6 ELR14436.1 - 1.5e-23 82.5 0.4 1.9e-10 40.8 0.1 4.9 3 2 2 5 5 5 3 Ankyrin repeats (many copies) APH PF01636.23 ELR14436.1 - 0.028 14.4 0.1 0.028 14.4 0.1 2.1 2 0 0 2 2 2 0 Phosphotransferase enzyme family Haspin_kinase PF12330.8 ELR14436.1 - 0.093 11.7 0.0 0.093 11.7 0.0 2.7 3 0 0 3 3 3 0 Haspin like kinase domain Pkinase_Tyr PF07714.17 ELR14437.1 - 0.023 14.0 0.0 0.025 13.9 0.0 1.1 1 0 0 1 1 1 0 Protein tyrosine kinase BTB_2 PF02214.22 ELR14438.1 - 2.6e-24 85.4 0.1 9.5e-24 83.6 0.0 2.0 2 0 0 2 2 2 1 BTB/POZ domain BTB_3 PF16017.5 ELR14438.1 - 7.6e-09 35.6 0.0 1.5e-08 34.7 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain MIF4G_like_2 PF09090.11 ELR14438.1 - 0.0057 16.2 4.7 0.014 14.9 0.0 2.5 1 1 1 2 2 2 1 MIF4G like Atypical_Card PF18461.1 ELR14438.1 - 0.0089 16.2 3.2 0.56 10.5 0.1 3.2 3 0 0 3 3 3 1 Atypical caspase recruitment domain ANAPC16 PF17256.2 ELR14438.1 - 0.045 14.1 0.2 0.15 12.5 0.2 1.8 1 0 0 1 1 1 0 Anaphase-promoting complex, subunit 16 V_ATPase_I PF01496.19 ELR14438.1 - 0.14 10.1 5.8 0.15 9.9 5.8 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Apolipoprotein PF01442.18 ELR14438.1 - 0.35 10.7 22.2 3.9 7.3 19.5 3.0 2 1 0 2 2 2 0 Apolipoprotein A1/A4/E domain Baculo_PEP_C PF04513.12 ELR14438.1 - 1.1 9.3 12.9 6.4e+02 0.3 0.0 3.5 2 1 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus FdhE PF04216.12 ELR14438.1 - 4.3 7.1 14.8 0.075 12.9 3.1 2.6 2 1 1 3 3 3 0 Protein involved in formate dehydrogenase formation RasGAP PF00616.19 ELR14440.1 - 4.4e-20 72.3 0.2 4.8e-13 49.3 0.0 2.7 2 1 1 3 3 3 2 GTPase-activator protein for Ras-like GTPase D123 PF07065.14 ELR14441.1 - 4e-18 65.6 0.0 7.3e-17 61.5 0.0 2.2 2 1 0 2 2 2 1 D123 R2K_3 PF14243.6 ELR14441.1 - 2.4e-07 31.0 0.2 7.1e-07 29.4 0.0 1.8 2 0 0 2 2 2 1 ATP-grasp domain, R2K clade family 3 R2K_2 PF18299.1 ELR14441.1 - 6.2e-07 29.4 0.0 1.1e-06 28.5 0.0 1.5 1 0 0 1 1 1 1 ATP-grasp domain, R2K clade family 2 PI3_PI4_kinase PF00454.27 ELR14442.1 - 4e-25 89.1 0.0 1.1e-21 77.8 0.0 2.2 1 1 0 2 2 2 2 Phosphatidylinositol 3- and 4-kinase PI3Ka PF00613.20 ELR14442.1 - 1.4e-06 27.8 0.1 8.7e-06 25.3 0.0 2.2 3 0 0 3 3 3 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) PBP1_TM PF14812.6 ELR14442.1 - 0.16 12.3 4.2 2.4 8.6 2.1 2.4 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal COG5 PF10392.9 ELR14443.1 - 6.8e-26 91.0 4.1 6.8e-26 91.0 4.1 3.5 3 0 0 3 3 3 1 Golgi transport complex subunit 5 Vps54_N PF10475.9 ELR14443.1 - 7.6e-08 32.0 6.2 1.7e-07 30.8 6.2 1.5 1 0 0 1 1 1 1 Vacuolar-sorting protein 54, of GARP complex Vps51 PF08700.11 ELR14443.1 - 2.7e-05 24.1 2.2 7.6e-05 22.7 0.2 2.8 3 0 0 3 3 3 1 Vps51/Vps67 Baculo_PEP_C PF04513.12 ELR14443.1 - 0.00089 19.3 10.0 0.022 14.8 0.3 4.1 4 0 0 4 4 4 2 Baculovirus polyhedron envelope protein, PEP, C terminus DUF489 PF04356.12 ELR14443.1 - 0.0062 16.6 13.2 0.033 14.2 0.4 5.0 3 2 3 6 6 6 1 Protein of unknown function (DUF489) Sec5 PF15469.6 ELR14443.1 - 0.011 15.6 1.5 0.68 9.7 0.1 3.6 4 1 0 4 4 4 0 Exocyst complex component Sec5 COG2 PF06148.11 ELR14443.1 - 0.014 15.5 0.6 0.014 15.5 0.6 3.0 4 0 0 4 4 4 0 COG (conserved oligomeric Golgi) complex component, COG2 NPV_P10 PF05531.12 ELR14443.1 - 0.018 15.5 3.4 1 9.9 0.4 4.0 3 1 0 3 3 3 0 Nucleopolyhedrovirus P10 protein Cob_adeno_trans PF01923.18 ELR14443.1 - 0.034 14.3 4.1 0.34 11.0 0.8 3.3 2 1 1 3 3 3 0 Cobalamin adenosyltransferase Cluap1 PF10234.9 ELR14443.1 - 0.57 9.5 8.1 0.48 9.8 2.6 2.5 1 1 1 2 2 2 0 Clusterin-associated protein-1 RasGAP_C PF03836.15 ELR14443.1 - 1.4 9.0 7.0 3.8 7.7 0.5 3.5 3 1 1 4 4 4 0 RasGAP C-terminus Fib_alpha PF08702.10 ELR14443.1 - 2.1 8.5 5.1 5.1 7.3 0.4 3.3 3 0 0 3 3 3 0 Fibrinogen alpha/beta chain family DUF1664 PF07889.12 ELR14443.1 - 2.4 8.2 7.8 2.1 8.4 0.2 3.8 4 1 0 4 4 4 0 Protein of unknown function (DUF1664) Mito_carr PF00153.27 ELR14444.1 - 2.4e-68 226.1 3.3 1e-22 79.8 0.0 3.4 3 1 0 3 3 3 3 Mitochondrial carrier protein Melibiase_2 PF16499.5 ELR14445.1 - 1.7e-67 227.6 4.4 3.7e-67 226.5 4.4 1.5 1 1 0 1 1 1 1 Alpha galactosidase A Melibiase_C PF17801.1 ELR14445.1 - 6.7e-15 54.9 0.5 2.3e-14 53.2 0.4 2.0 1 1 1 2 2 2 1 Alpha galactosidase C-terminal beta sandwich domain Melibiase PF02065.18 ELR14445.1 - 8.6e-07 28.2 0.0 1.6e-06 27.3 0.0 1.3 1 0 0 1 1 1 1 Melibiase Melibiase_2_C PF17450.2 ELR14445.1 - 0.0014 18.8 0.0 0.0034 17.6 0.0 1.7 1 0 0 1 1 1 1 Alpha galactosidase A C-terminal beta sandwich domain DUF2804 PF10974.8 ELR14447.1 - 4.2e-69 233.6 0.1 5.4e-69 233.2 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2804) zf-RanBP PF00641.18 ELR14448.1 - 5.2e-06 25.7 9.5 2.3e-05 23.6 2.5 2.3 2 0 0 2 2 2 2 Zn-finger in Ran binding protein and others AvrRpt-cleavage PF05627.11 ELR14448.1 - 0.0099 15.2 0.8 3.1 7.2 0.1 2.3 2 0 0 2 2 2 2 Cleavage site for pathogenic type III effector avirulence factor Avr COE1_HLH PF16423.5 ELR14448.1 - 0.069 12.9 0.2 15 5.3 0.1 2.3 2 0 0 2 2 2 0 Transcription factor COE1 helix-loop-helix domain GP4 PF03010.14 ELR14449.1 - 0.16 11.9 0.0 0.18 11.7 0.0 1.1 1 0 0 1 1 1 0 GP4 CS PF04969.16 ELR14450.1 - 6.6e-15 55.9 0.3 6.6e-15 55.9 0.3 1.6 2 0 0 2 2 1 1 CS domain TPR_2 PF07719.17 ELR14450.1 - 1.2e-13 50.0 6.1 0.0015 18.5 0.2 3.6 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_1 PF00515.28 ELR14450.1 - 5e-11 41.9 3.9 0.00072 19.3 0.1 3.6 4 0 0 4 4 4 3 Tetratricopeptide repeat SGS PF05002.15 ELR14450.1 - 5.3e-11 42.5 0.1 1.1e-10 41.4 0.1 1.6 1 0 0 1 1 1 1 SGS domain TPR_16 PF13432.6 ELR14450.1 - 1.5e-09 38.3 12.9 2.9e-06 27.8 0.7 2.9 2 1 1 3 3 2 2 Tetratricopeptide repeat TPR_14 PF13428.6 ELR14450.1 - 6.4e-07 29.7 6.8 0.0029 18.3 0.5 3.9 1 1 2 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 ELR14450.1 - 1.5e-06 27.9 0.3 0.12 12.6 0.0 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_9 PF13371.6 ELR14450.1 - 4.8e-06 26.6 2.4 6.6e-05 23.0 0.5 2.3 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_19 PF14559.6 ELR14450.1 - 7.1e-06 26.4 5.7 3.5e-05 24.2 2.2 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.6 ELR14450.1 - 2.1e-05 24.7 2.8 0.001 19.3 0.4 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_11 PF13414.6 ELR14450.1 - 2.3e-05 24.0 1.9 0.078 12.7 0.3 3.4 2 1 1 3 3 3 2 TPR repeat Fis1_TPR_C PF14853.6 ELR14450.1 - 0.00033 20.7 0.1 1.4 9.1 0.0 2.4 2 0 0 2 2 2 2 Fis1 C-terminal tetratricopeptide repeat MSA-2c PF12238.8 ELR14450.1 - 0.065 13.2 4.4 0.099 12.6 4.4 1.4 1 0 0 1 1 1 0 Merozoite surface antigen 2c MIT PF04212.18 ELR14450.1 - 0.087 12.9 0.1 1.5 8.9 0.0 2.5 2 0 0 2 2 2 0 MIT (microtubule interacting and transport) domain TPR_6 PF13174.6 ELR14450.1 - 0.15 12.8 4.1 3.4 8.5 0.7 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat ANAPC3 PF12895.7 ELR14450.1 - 0.15 12.3 1.1 0.37 11.0 1.0 1.7 1 1 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 3 RPAP2_Rtr1 PF04181.13 ELR14451.1 - 3.2e-17 62.6 0.0 5.3e-17 61.9 0.0 1.4 1 0 0 1 1 1 1 Rtr1/RPAP2 family PEPCK_GTP PF00821.18 ELR14452.1 - 1.2e-175 583.5 0.2 1.5e-175 583.2 0.2 1.1 1 0 0 1 1 1 1 Phosphoenolpyruvate carboxykinase C-terminal P-loop domain PEPCK_N PF17297.2 ELR14452.1 - 5.7e-105 349.8 0.0 7.6e-105 349.3 0.0 1.2 1 0 0 1 1 1 1 Phosphoenolpyruvate carboxykinase N-terminal domain RRM_1 PF00076.22 ELR14453.1 - 1.1e-16 60.4 0.0 1.6e-16 59.9 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) GRP PF07172.11 ELR14453.1 - 0.19 12.4 26.3 0.3 11.8 26.3 1.3 1 0 0 1 1 1 0 Glycine rich protein family RRM_5 PF13893.6 ELR14453.1 - 0.22 11.1 0.0 0.33 10.5 0.0 1.3 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) ALG11_N PF15924.5 ELR14454.1 - 2.1e-74 250.1 0.1 9.1e-73 244.8 0.1 2.1 1 1 0 1 1 1 1 ALG11 mannosyltransferase N-terminus Glycos_transf_1 PF00534.20 ELR14454.1 - 3.4e-23 82.0 0.0 4.9e-23 81.5 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 ELR14454.1 - 1.1e-15 58.2 0.2 6.9e-15 55.7 0.1 2.0 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 ELR14454.1 - 0.0078 16.2 0.1 0.019 15.0 0.1 1.6 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Pex2_Pex12 PF04757.14 ELR14455.1 - 8.1e-47 159.7 0.0 1.1e-46 159.3 0.0 1.2 1 0 0 1 1 1 1 Pex2 / Pex12 amino terminal region zf-C3HC4_2 PF13923.6 ELR14455.1 - 0.00016 21.5 0.7 0.00026 20.7 0.7 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 ELR14455.1 - 0.0027 17.5 0.4 0.004 17.0 0.4 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 ELR14455.1 - 0.011 16.1 0.3 0.017 15.4 0.3 1.3 1 0 0 1 1 1 0 Ring finger domain REV PF00424.18 ELR14455.1 - 0.13 12.3 1.2 0.23 11.5 0.2 1.9 2 0 0 2 2 2 0 REV protein (anti-repression trans-activator protein) zf-RING_UBOX PF13445.6 ELR14455.1 - 0.53 10.3 2.6 0.87 9.7 2.6 1.3 1 0 0 1 1 1 0 RING-type zinc-finger Isy1 PF06246.12 ELR14456.1 - 2.2e-82 276.5 7.1 2.5e-82 276.3 7.1 1.0 1 0 0 1 1 1 1 Isy1-like splicing family Ribosomal_L13 PF00572.18 ELR14457.1 - 3.2e-50 169.6 0.6 5.3e-50 168.9 0.3 1.5 2 0 0 2 2 2 1 Ribosomal protein L13 Trm56 PF01994.16 ELR14457.1 - 0.081 12.9 0.0 0.15 12.0 0.0 1.4 1 0 0 1 1 1 0 tRNA ribose 2'-O-methyltransferase, aTrm56 6PGD PF00393.19 ELR14458.1 - 3.1e-124 414.1 0.0 3.8e-124 413.8 0.0 1.1 1 0 0 1 1 1 1 6-phosphogluconate dehydrogenase, C-terminal domain NAD_binding_2 PF03446.15 ELR14458.1 - 1.5e-44 152.0 0.1 2.1e-44 151.5 0.1 1.2 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.6 ELR14458.1 - 0.042 14.1 0.1 0.65 10.2 0.0 2.5 2 0 0 2 2 2 0 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase Cation_efflux PF01545.21 ELR14459.1 - 6.5e-14 52.1 14.4 6.1e-13 49.0 4.4 2.1 1 1 1 2 2 2 2 Cation efflux family Sensor PF13796.6 ELR14459.1 - 0.75 9.8 21.9 0.065 13.3 3.7 2.3 2 0 0 2 2 2 0 Putative sensor FA_desaturase PF00487.24 ELR14459.1 - 1.9 8.3 11.1 0.089 12.6 0.7 2.1 1 1 1 2 2 2 0 Fatty acid desaturase Myosin_head PF00063.21 ELR14460.1 - 1.4e-197 658.1 0.0 1.4e-177 592.0 0.0 2.1 2 0 0 2 2 2 2 Myosin head (motor domain) IQ PF00612.27 ELR14460.1 - 1.1e-05 24.8 13.4 0.0033 17.1 2.1 2.9 2 0 0 2 2 2 2 IQ calmodulin-binding motif Ras PF00071.22 ELR14462.1 - 8.7e-32 110.0 0.1 2.1e-26 92.5 0.0 2.3 2 0 0 2 2 2 2 Ras family Aldo_ket_red PF00248.21 ELR14462.1 - 7.3e-06 25.4 0.0 1.3e-05 24.6 0.0 1.3 1 0 0 1 1 1 1 Aldo/keto reductase family Roc PF08477.13 ELR14462.1 - 1.3e-05 25.3 0.0 0.0018 18.5 0.0 2.5 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase CENP-M PF11111.8 ELR14462.1 - 0.0013 18.0 0.0 0.0036 16.5 0.0 1.7 1 0 0 1 1 1 1 Centromere protein M (CENP-M) CAF1C_H4-bd PF12265.8 ELR14462.1 - 0.007 16.6 0.1 0.014 15.6 0.1 1.5 1 0 0 1 1 1 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex TFIIA PF03153.13 ELR14462.1 - 0.41 10.6 6.1 0.53 10.2 6.1 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit TPR_12 PF13424.6 ELR14463.1 - 0.019 15.2 3.2 0.038 14.3 0.4 2.4 1 1 0 2 2 2 0 Tetratricopeptide repeat TPR_1 PF00515.28 ELR14463.1 - 0.045 13.6 2.1 0.23 11.3 0.2 2.6 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_2 PF07719.17 ELR14463.1 - 0.11 12.7 3.8 1 9.7 0.6 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat Metallophos PF00149.28 ELR14464.1 - 3.2e-25 89.9 0.1 5.2e-25 89.2 0.1 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase EF-hand_8 PF13833.6 ELR14464.1 - 1.7e-19 69.4 5.4 8.4e-05 22.3 0.1 6.1 5 1 1 6 6 6 4 EF-hand domain pair EF-hand_1 PF00036.32 ELR14464.1 - 2.4e-18 64.2 8.8 0.0005 19.4 0.7 6.4 6 0 0 6 6 6 4 EF hand EF-hand_6 PF13405.6 ELR14464.1 - 1.8e-15 55.4 11.6 0.012 15.5 1.0 6.5 6 1 0 6 6 6 5 EF-hand domain EF-hand_7 PF13499.6 ELR14464.1 - 5.6e-14 52.4 12.7 4.3e-05 23.9 2.4 5.0 4 2 1 5 5 5 4 EF-hand domain pair EF-hand_5 PF13202.6 ELR14464.1 - 4.1e-10 38.7 13.3 0.024 14.1 0.4 6.2 6 1 0 6 6 6 4 EF hand EF-hand_4 PF12763.7 ELR14464.1 - 7.7e-06 25.8 0.6 0.27 11.2 0.0 3.6 4 0 0 4 4 4 2 Cytoskeletal-regulatory complex EF hand DUF2141 PF09912.9 ELR14464.1 - 0.047 13.6 0.1 5.5 6.9 0.0 2.5 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2141) PPP5 PF08321.12 ELR14464.1 - 0.058 13.7 0.1 0.24 11.7 0.0 2.0 2 0 0 2 2 2 0 PPP5 TPR repeat region Pkinase PF00069.25 ELR14465.1 - 4.1e-58 196.8 0.5 1.3e-51 175.6 0.3 2.1 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ELR14465.1 - 5.8e-27 94.6 0.0 7.8e-27 94.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 ELR14465.1 - 7.5e-07 28.7 0.0 1.1e-06 28.2 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 ELR14465.1 - 0.00051 20.0 0.0 0.76 9.7 0.0 2.2 1 1 1 2 2 2 2 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 ELR14465.1 - 0.00071 18.5 0.2 0.002 17.0 0.0 1.7 2 0 0 2 2 2 1 Fungal protein kinase RIO1 PF01163.22 ELR14465.1 - 0.0037 16.9 0.3 0.0053 16.4 0.3 1.2 1 0 0 1 1 1 1 RIO1 family FTA2 PF13095.6 ELR14465.1 - 0.075 12.6 0.1 0.22 11.1 0.1 1.7 2 1 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Y_phosphatase PF00102.27 ELR14467.1 - 2e-35 122.4 0.2 1.2e-34 120.0 0.2 1.8 1 1 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.6 ELR14467.1 - 0.088 12.8 0.0 0.11 12.4 0.0 1.2 1 0 0 1 1 1 0 Tyrosine phosphatase family CH PF00307.31 ELR14468.1 - 3.1e-28 98.1 0.1 2e-15 56.9 0.0 3.8 3 1 0 3 3 3 2 Calponin homology (CH) domain PH PF00169.29 ELR14468.1 - 5.1e-19 68.7 1.4 2e-18 66.8 1.4 2.1 1 0 0 1 1 1 1 PH domain PH_8 PF15409.6 ELR14468.1 - 0.0001 22.5 0.2 0.00026 21.2 0.2 1.7 1 0 0 1 1 1 1 Pleckstrin homology domain Spc7 PF08317.11 ELR14468.1 - 0.00022 20.2 40.3 0.00022 20.2 40.3 3.0 1 1 1 2 2 2 1 Spc7 kinetochore protein PH_11 PF15413.6 ELR14468.1 - 0.00035 21.0 4.9 0.0043 17.5 4.9 2.7 1 1 0 1 1 1 1 Pleckstrin homology domain YabA PF06156.13 ELR14468.1 - 0.0015 19.1 11.7 0.0015 19.1 11.7 4.9 1 1 3 4 4 3 1 Initiation control protein YabA PH_9 PF15410.6 ELR14468.1 - 0.0026 18.1 0.5 0.022 15.1 0.5 2.3 1 1 0 1 1 1 1 Pleckstrin homology domain DUF1664 PF07889.12 ELR14468.1 - 0.017 15.2 29.8 0.056 13.5 8.9 4.5 1 1 2 4 4 4 0 Protein of unknown function (DUF1664) PH_13 PF16652.5 ELR14468.1 - 0.28 11.0 0.1 0.28 11.0 0.1 3.0 3 0 0 3 3 3 0 Pleckstrin homology domain Golgin_A5 PF09787.9 ELR14468.1 - 0.31 10.5 68.8 0.013 15.0 21.3 3.8 1 1 3 4 4 4 0 Golgin subfamily A member 5 Shugoshin_N PF07558.11 ELR14468.1 - 2.2 8.2 11.2 1.4 8.8 4.5 2.8 2 0 0 2 2 2 0 Shugoshin N-terminal coiled-coil region HOOK PF05622.12 ELR14468.1 - 2.3 6.3 71.2 1.7 6.7 28.3 2.2 1 1 1 2 2 2 0 HOOK protein TPR_MLP1_2 PF07926.12 ELR14468.1 - 2.5 8.2 82.9 0.2 11.7 19.3 4.5 1 1 3 4 4 4 0 TPR/MLP1/MLP2-like protein DUF948 PF06103.11 ELR14468.1 - 7.9 6.8 20.6 11 6.3 0.0 5.0 2 1 2 4 4 4 0 Bacterial protein of unknown function (DUF948) Pkinase PF00069.25 ELR14470.1 - 4.7e-62 209.7 0.0 2.3e-61 207.5 0.0 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR14470.1 - 5.3e-33 114.4 0.0 4.7e-32 111.3 0.0 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase GRAM PF02893.20 ELR14470.1 - 8.1e-20 70.8 0.1 1.4e-19 70.1 0.1 1.3 1 0 0 1 1 1 1 GRAM domain Kinase-like PF14531.6 ELR14470.1 - 3.8e-05 23.2 0.2 0.00019 20.9 0.1 2.2 2 1 1 3 3 3 1 Kinase-like Pkinase_fungal PF17667.1 ELR14470.1 - 0.001 17.9 0.0 0.0015 17.4 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 ELR14470.1 - 0.02 14.8 4.2 0.39 10.6 0.1 2.8 2 1 1 3 3 3 0 Phosphotransferase enzyme family Kdo PF06293.14 ELR14470.1 - 0.027 13.8 0.3 0.062 12.7 0.3 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family eIF3m_C_helix PF18005.1 ELR14471.1 - 6.5e-11 41.7 1.0 1.4e-10 40.6 1.0 1.6 1 0 0 1 1 1 1 eIF3 subunit M, C-terminal helix PCI PF01399.27 ELR14471.1 - 6.8e-10 39.4 0.0 1.7e-09 38.2 0.0 1.7 1 0 0 1 1 1 1 PCI domain Sigma70_r4_2 PF08281.12 ELR14471.1 - 0.012 15.3 0.1 0.041 13.6 0.1 1.9 1 0 0 1 1 1 0 Sigma-70, region 4 Cys_Met_Meta_PP PF01053.20 ELR14472.1 - 4.1e-156 519.3 0.0 4.6e-156 519.1 0.0 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_1_2 PF00155.21 ELR14472.1 - 3.9e-07 29.6 0.0 5.6e-07 29.1 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class I and II DegT_DnrJ_EryC1 PF01041.17 ELR14472.1 - 2.2e-06 27.2 0.1 1e-05 25.0 0.1 2.0 1 1 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_5 PF00266.19 ELR14472.1 - 0.00029 19.9 0.0 0.00057 18.9 0.0 1.4 1 0 0 1 1 1 1 Aminotransferase class-V Met_gamma_lyase PF06838.11 ELR14472.1 - 0.00039 19.1 0.0 0.00076 18.1 0.0 1.5 1 1 0 1 1 1 1 Methionine gamma-lyase ThiF PF00899.21 ELR14473.1 - 2.8e-95 318.3 0.0 9.9e-70 234.7 0.0 2.2 2 0 0 2 2 2 2 ThiF family UBA_e1_thiolCys PF10585.9 ELR14473.1 - 4.7e-88 295.3 0.0 6.4e-88 294.9 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-activating enzyme active site E1_UFD PF09358.10 ELR14473.1 - 2.7e-30 104.9 0.1 5.1e-30 104.0 0.1 1.5 1 0 0 1 1 1 1 Ubiquitin fold domain E1_FCCH PF16190.5 ELR14473.1 - 6.7e-28 96.7 0.0 1.3e-27 95.8 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin-activating enzyme E1 FCCH domain E1_4HB PF16191.5 ELR14473.1 - 1.1e-16 60.8 0.0 2.1e-16 59.9 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin-activating enzyme E1 four-helix bundle Ost5 PF05251.12 ELR14474.1 - 1.9e-25 88.9 5.5 2.3e-25 88.7 5.5 1.1 1 0 0 1 1 1 1 Oligosaccharyltransferase subunit 5 Phage_holin_3_3 PF16083.5 ELR14474.1 - 0.0022 18.1 0.4 0.003 17.6 0.2 1.4 1 1 0 1 1 1 1 LydA holin phage, holin superfamily III Phage_holin_3_6 PF07332.11 ELR14474.1 - 5.4 7.1 8.0 1.8 8.6 0.3 2.0 1 1 1 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III WD40 PF00400.32 ELR14475.1 - 2.1e-22 79.0 11.2 0.0013 19.6 0.0 7.4 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ELR14475.1 - 7.9e-05 22.9 0.0 8.1 6.8 0.0 3.8 4 0 0 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ELR14475.1 - 0.063 11.9 0.6 8.2 4.9 0.0 2.6 2 1 1 3 3 3 0 Nucleoporin Nup120/160 MIF4G_like_2 PF09090.11 ELR14476.1 - 1.2e-50 172.4 1.5 2.3e-50 171.6 1.5 1.4 1 0 0 1 1 1 1 MIF4G like MIF4G_like PF09088.11 ELR14476.1 - 2.1e-39 135.3 0.5 3.3e-37 128.1 0.1 2.9 2 1 1 3 3 3 2 MIF4G like MIF4G PF02854.19 ELR14476.1 - 7.1e-11 42.1 0.0 2.5e-10 40.4 0.0 1.9 2 0 0 2 2 2 1 MIF4G domain DHO_dh PF01180.21 ELR14477.1 - 7.8e-37 127.1 0.0 1.4e-36 126.3 0.0 1.3 1 0 0 1 1 1 1 Dihydroorotate dehydrogenase Fer4_20 PF14691.6 ELR14477.1 - 8.7e-31 106.0 0.3 8.7e-31 106.0 0.3 2.8 2 1 0 2 2 1 1 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster Fer4_21 PF14697.6 ELR14477.1 - 1.4e-23 82.8 14.1 1.4e-23 82.8 14.1 3.0 3 0 0 3 3 2 1 4Fe-4S dicluster domain Pyr_redox_2 PF07992.14 ELR14477.1 - 5.6e-13 48.8 0.0 1.1e-12 47.9 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Fer4_10 PF13237.6 ELR14477.1 - 6.5e-08 32.6 24.2 1.7e-05 24.8 10.4 2.8 2 0 0 2 2 2 2 4Fe-4S dicluster domain Fer4_7 PF12838.7 ELR14477.1 - 2.6e-05 24.7 11.5 2.6e-05 24.7 11.5 3.5 3 0 0 3 3 2 2 4Fe-4S dicluster domain Fer4_6 PF12837.7 ELR14477.1 - 6.1e-05 22.9 2.2 6.1e-05 22.9 2.2 4.6 4 1 0 4 4 4 2 4Fe-4S binding domain Fer4_2 PF12797.7 ELR14477.1 - 0.00068 19.6 37.6 0.0027 17.7 3.1 4.9 5 0 0 5 5 4 3 4Fe-4S binding domain Fer4 PF00037.27 ELR14477.1 - 0.0014 18.3 31.9 0.0028 17.4 5.0 4.9 5 0 0 5 5 5 2 4Fe-4S binding domain Pyr_redox_3 PF13738.6 ELR14477.1 - 0.0019 17.5 0.1 1.4 8.1 0.0 2.9 3 1 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 ELR14477.1 - 0.0024 18.1 0.0 0.007 16.6 0.0 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Fer4_9 PF13187.6 ELR14477.1 - 0.0071 16.5 13.7 0.0071 16.5 13.7 3.1 3 0 0 3 3 3 2 4Fe-4S dicluster domain Dus PF01207.17 ELR14477.1 - 0.011 14.8 0.1 0.037 13.1 0.1 1.8 1 1 0 1 1 1 0 Dihydrouridine synthase (Dus) Pyr_redox PF00070.27 ELR14477.1 - 0.18 12.3 0.0 7.6 7.2 0.0 2.8 3 0 0 3 3 2 0 Pyridine nucleotide-disulphide oxidoreductase Glyco_transf_88 PF16849.5 ELR14477.1 - 0.2 10.5 0.0 0.33 9.8 0.0 1.2 1 0 0 1 1 1 0 Glycosyltransferase family 88 Fer4_15 PF13459.6 ELR14477.1 - 1.9 9.3 12.2 11 6.9 2.2 2.8 1 1 1 2 2 2 0 4Fe-4S single cluster domain Fer4_17 PF13534.6 ELR14477.1 - 2.8 8.5 26.3 0.19 12.3 0.8 3.9 4 0 0 4 4 3 0 4Fe-4S dicluster domain Fer4_13 PF13370.6 ELR14477.1 - 5.9 7.5 24.7 0.12 12.9 3.8 3.8 4 0 0 4 4 3 0 4Fe-4S single cluster domain of Ferredoxin I EF-hand_1 PF00036.32 ELR14478.1 - 8.3e-36 118.9 16.6 2e-09 36.3 1.8 4.1 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 ELR14478.1 - 6.8e-30 103.3 7.0 9.1e-15 54.9 1.3 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 ELR14478.1 - 5.9e-29 97.5 9.7 3.9e-08 32.6 0.0 4.2 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.6 ELR14478.1 - 6.5e-26 88.6 14.9 5.5e-06 25.6 0.0 4.2 4 0 0 4 4 4 4 EF hand EF-hand_8 PF13833.6 ELR14478.1 - 2e-25 88.4 15.8 3.4e-10 39.6 2.1 4.1 1 1 3 4 4 4 4 EF-hand domain pair EF-hand_9 PF14658.6 ELR14478.1 - 4e-15 55.9 0.1 9.9e-08 32.2 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.7 ELR14478.1 - 4.6e-10 39.4 2.2 0.00036 20.4 0.1 2.2 2 0 0 2 2 2 2 Cytoskeletal-regulatory complex EF hand Dockerin_1 PF00404.18 ELR14478.1 - 8.2e-09 35.5 2.7 0.0027 17.8 0.0 3.2 1 1 2 3 3 3 3 Dockerin type I domain SPARC_Ca_bdg PF10591.9 ELR14478.1 - 9.6e-09 35.6 0.7 0.0041 17.4 0.1 2.1 2 0 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_11 PF08976.11 ELR14478.1 - 6.7e-07 30.1 0.0 0.032 15.1 0.0 2.0 1 1 1 2 2 2 2 EF-hand domain EF-hand_14 PF17959.1 ELR14478.1 - 2.9e-06 27.6 1.0 0.026 14.8 0.1 2.9 2 1 0 2 2 2 2 EF-hand domain UPF0154 PF03672.13 ELR14478.1 - 4.1e-05 23.5 0.5 0.2 11.7 0.0 2.5 3 0 0 3 3 2 2 Uncharacterised protein family (UPF0154) Caleosin PF05042.13 ELR14478.1 - 0.016 15.1 0.5 15 5.5 0.0 3.3 1 1 3 4 4 4 0 Caleosin related protein TerB PF05099.13 ELR14478.1 - 0.018 15.0 1.0 0.21 11.6 0.2 2.1 1 1 0 2 2 2 0 Tellurite resistance protein TerB SurA_N_2 PF13623.6 ELR14478.1 - 0.033 14.1 2.2 1.8 8.4 0.6 2.2 1 1 1 2 2 2 0 SurA N-terminal domain EF-hand_10 PF14788.6 ELR14478.1 - 0.04 13.8 2.2 1.4 8.9 0.2 2.9 2 1 0 2 2 2 0 EF hand DUF5580 PF17743.1 ELR14478.1 - 0.081 11.4 0.0 0.23 9.9 0.0 1.6 1 1 0 1 1 1 0 Family of unknown function (DUF5580) RNA_pol_Rpb4 PF03874.16 ELR14478.1 - 0.16 12.3 2.8 4.1 7.7 0.2 2.4 2 0 0 2 2 2 0 RNA polymerase Rpb4 B5 PF03484.15 ELR14478.1 - 0.18 12.1 1.1 8.5 6.8 0.2 2.5 2 1 0 2 2 2 0 tRNA synthetase B5 domain DUF1456 PF07308.13 ELR14478.1 - 0.44 10.9 3.0 2.3 8.6 0.2 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF1456) RhoGEF PF00621.20 ELR14479.1 - 2.4e-46 158.3 0.2 2.4e-46 158.3 0.2 2.4 2 1 0 2 2 2 1 RhoGEF domain PH PF00169.29 ELR14479.1 - 3.9e-08 33.7 1.4 1.5e-07 31.8 1.4 2.0 1 1 0 1 1 1 1 PH domain IQ_SEC7_PH PF16453.5 ELR14479.1 - 1.6e-06 28.1 0.5 3.8e-06 26.9 0.5 1.6 1 0 0 1 1 1 1 PH domain PH_13 PF16652.5 ELR14479.1 - 0.001 18.9 2.7 0.001 18.9 2.7 2.1 2 0 0 2 2 2 1 Pleckstrin homology domain IQ PF00612.27 ELR14479.1 - 0.0011 18.5 2.4 0.0032 17.1 2.4 1.8 1 0 0 1 1 1 1 IQ calmodulin-binding motif Hrs_helical PF12210.8 ELR14479.1 - 0.91 10.1 7.3 1.9 9.1 0.0 4.4 5 0 0 5 5 5 0 Hepatocyte growth factor-regulated tyrosine kinase substrate L51_S25_CI-B8 PF05047.16 ELR14480.1 - 2.4e-08 33.7 0.0 3.7e-08 33.2 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain BTB_2 PF02214.22 ELR14482.1 - 6e-10 39.4 0.2 5.9e-08 32.9 0.0 2.4 1 1 1 2 2 2 1 BTB/POZ domain WD40 PF00400.32 ELR14482.1 - 0.32 11.9 14.0 3.2 8.8 0.2 5.8 6 0 0 6 6 6 0 WD domain, G-beta repeat RNA_pol_Rpc4 PF05132.14 ELR14482.1 - 0.39 11.1 16.6 0.028 14.8 3.4 3.5 3 0 0 3 3 3 0 RNA polymerase III RPC4 Hid1 PF12722.7 ELR14482.1 - 0.8 7.8 3.5 1.4 7.0 3.5 1.3 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein DUF4407 PF14362.6 ELR14482.1 - 0.91 8.8 4.8 4.6 6.5 0.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) TFIIA PF03153.13 ELR14482.1 - 1.4 8.9 14.8 0.54 10.2 8.1 2.6 3 0 0 3 3 3 0 Transcription factor IIA, alpha/beta subunit Roughex PF06020.11 ELR14482.1 - 1.7 7.7 15.7 3.4 6.7 9.1 2.3 2 0 0 2 2 2 0 Drosophila roughex protein SUIM_assoc PF16619.5 ELR14482.1 - 1.9 8.6 24.6 3.7 7.7 16.1 2.9 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 GREB1 PF15782.5 ELR14482.1 - 3.5 4.6 9.9 6.6 3.7 9.9 1.3 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer SRP-alpha_N PF04086.13 ELR14482.1 - 9.4 6.1 21.1 0.1 12.5 5.4 3.0 3 0 0 3 3 3 0 Signal recognition particle, alpha subunit, N-terminal ABC2_membrane PF01061.24 ELR14483.1 - 3.4e-75 252.1 55.1 9.3e-41 139.6 20.2 2.6 3 0 0 3 3 3 2 ABC-2 type transporter ABC_tran PF00005.27 ELR14483.1 - 2.4e-46 157.6 0.0 2.9e-24 86.1 0.0 2.4 2 0 0 2 2 2 2 ABC transporter RsgA_GTPase PF03193.16 ELR14483.1 - 3.8e-09 36.7 0.3 0.00068 19.6 0.2 2.3 2 0 0 2 2 2 2 RsgA GTPase AAA_29 PF13555.6 ELR14483.1 - 4.3e-07 29.6 0.3 0.0061 16.3 0.1 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_16 PF13191.6 ELR14483.1 - 9.9e-07 29.3 1.5 0.018 15.4 0.1 3.2 3 1 0 3 3 3 2 AAA ATPase domain AAA_21 PF13304.6 ELR14483.1 - 4.4e-06 26.7 0.0 1.1 9.0 0.0 4.1 4 0 0 4 4 4 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_25 PF13481.6 ELR14483.1 - 5.3e-06 26.2 0.3 0.11 12.1 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_22 PF13401.6 ELR14483.1 - 2.2e-05 24.8 0.1 0.2 11.9 0.0 3.0 3 0 0 3 3 3 2 AAA domain AAA_28 PF13521.6 ELR14483.1 - 0.00018 21.8 0.3 0.18 12.0 0.0 2.8 2 0 0 2 2 2 1 AAA domain MMR_HSR1 PF01926.23 ELR14483.1 - 0.00043 20.3 0.4 0.66 10.1 0.0 2.7 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_18 PF13238.6 ELR14483.1 - 0.00083 19.9 0.2 0.38 11.3 0.0 2.7 2 0 0 2 2 2 1 AAA domain PDR_CDR PF06422.12 ELR14483.1 - 0.001 18.9 7.9 0.024 14.5 0.0 3.9 4 0 0 4 4 3 1 CDR ABC transporter RNA_helicase PF00910.22 ELR14483.1 - 0.0012 19.2 0.1 1.2 9.5 0.0 2.6 2 0 0 2 2 2 1 RNA helicase Rad17 PF03215.15 ELR14483.1 - 0.0019 18.2 0.1 0.44 10.5 0.0 2.4 2 0 0 2 2 2 1 Rad17 P-loop domain Zeta_toxin PF06414.12 ELR14483.1 - 0.0032 16.8 0.4 0.64 9.3 0.0 2.5 2 0 0 2 2 2 1 Zeta toxin NACHT PF05729.12 ELR14483.1 - 0.0041 17.1 2.4 0.26 11.2 0.1 2.5 2 0 0 2 2 2 1 NACHT domain AAA_23 PF13476.6 ELR14483.1 - 0.0063 17.0 0.1 4.1 7.9 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA PF00004.29 ELR14483.1 - 0.007 16.8 0.4 0.094 13.1 0.0 2.6 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) DUF815 PF05673.13 ELR14483.1 - 0.0084 15.3 0.6 0.2 10.8 0.0 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF815) AAA_5 PF07728.14 ELR14483.1 - 0.012 15.6 1.0 0.26 11.3 0.2 2.5 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_33 PF13671.6 ELR14483.1 - 0.012 15.7 0.1 5 7.3 0.0 2.6 2 0 0 2 2 2 0 AAA domain AAA_30 PF13604.6 ELR14483.1 - 0.014 15.1 0.1 5.3 6.7 0.0 2.4 2 0 0 2 2 2 0 AAA domain Ploopntkinase3 PF18751.1 ELR14483.1 - 0.045 13.7 0.4 12 5.8 0.1 2.4 2 0 0 2 2 2 0 P-loop Nucleotide Kinase3 Viral_helicase1 PF01443.18 ELR14483.1 - 0.052 13.3 0.7 0.1 12.4 0.0 1.8 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase AAA_24 PF13479.6 ELR14483.1 - 0.14 11.8 1.0 12 5.5 0.2 2.3 2 0 0 2 2 2 0 AAA domain Fmp27_WPPW PF10359.9 ELR14483.1 - 0.15 10.9 1.2 0.3 9.9 1.2 1.4 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain DUF87 PF01935.17 ELR14483.1 - 0.25 11.4 0.9 2.6 8.1 0.3 2.3 2 0 0 2 2 2 0 Helicase HerA, central domain cobW PF02492.19 ELR14483.1 - 1.2 8.6 2.5 8.2 6.0 0.1 2.5 3 0 0 3 3 2 0 CobW/HypB/UreG, nucleotide-binding domain SPC25 PF06703.11 ELR14483.1 - 4.6 7.0 5.1 52 3.6 0.0 3.3 3 0 0 3 3 3 0 Microsomal signal peptidase 25 kDa subunit (SPC25) HECT PF00632.25 ELR14484.1 - 1.2e-67 228.6 0.0 1.6e-67 228.2 0.0 1.2 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) Filamin PF00630.19 ELR14484.1 - 1.9e-16 60.8 0.0 2.1e-08 34.9 0.0 2.4 2 0 0 2 2 2 2 Filamin/ABP280 repeat Invasin_D3 PF09134.10 ELR14484.1 - 0.0054 17.0 0.0 0.68 10.3 0.0 2.8 2 0 0 2 2 2 1 Invasin, domain 3 Big_1 PF02369.16 ELR14484.1 - 0.11 12.5 0.5 0.59 10.2 0.0 2.3 2 0 0 2 2 2 0 Bacterial Ig-like domain (group 1) Methyltransf_23 PF13489.6 ELR14485.1 - 2.1e-12 47.2 0.3 1.9e-11 44.1 0.3 2.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ELR14485.1 - 9.8e-12 45.4 1.4 5.2e-09 36.6 0.0 2.9 2 1 1 3 3 3 2 Methyltransferase domain Methyltransf_25 PF13649.6 ELR14485.1 - 8.4e-10 39.2 1.2 1.4e-05 25.7 0.0 3.0 2 2 1 3 3 3 2 Methyltransferase domain Methyltransf_12 PF08242.12 ELR14485.1 - 1.8e-09 38.2 0.1 2.1e-06 28.4 0.0 2.5 1 1 1 2 2 2 2 Methyltransferase domain Methyltransf_31 PF13847.6 ELR14485.1 - 4.5e-09 36.3 0.0 3.6e-06 26.8 0.0 2.4 1 1 1 2 2 2 2 Methyltransferase domain MTS PF05175.14 ELR14485.1 - 0.0003 20.4 0.2 0.008 15.7 0.1 2.3 1 1 1 2 2 2 1 Methyltransferase small domain Ubie_methyltran PF01209.18 ELR14485.1 - 0.00094 18.6 0.0 0.0036 16.7 0.0 1.8 1 1 1 2 2 2 1 ubiE/COQ5 methyltransferase family MetW PF07021.12 ELR14485.1 - 0.051 13.2 0.2 0.61 9.7 0.1 2.1 1 1 1 2 2 2 0 Methionine biosynthesis protein MetW Methyltransf_8 PF05148.15 ELR14485.1 - 0.18 11.7 0.0 5.3 6.8 0.0 2.3 1 1 0 1 1 1 0 Hypothetical methyltransferase DREV PF05219.12 ELR14485.1 - 0.18 10.9 0.1 2.9 6.9 0.0 2.4 2 1 1 3 3 3 0 DREV methyltransferase DUF3767 PF12597.8 ELR14486.1 - 1.2e-06 28.3 5.0 5e-06 26.3 5.0 2.0 1 1 0 1 1 1 1 Protein of unknown function (DUF3767) OTU PF02338.19 ELR14487.1 - 2.8e-16 60.2 0.0 4.7e-16 59.4 0.0 1.3 1 0 0 1 1 1 1 OTU-like cysteine protease Peptidase_C65 PF10275.9 ELR14487.1 - 0.0055 16.2 0.0 0.26 10.7 0.0 2.1 2 0 0 2 2 2 2 Peptidase C65 Otubain UIM PF02809.20 ELR14487.1 - 0.082 12.9 3.9 0.33 11.0 3.9 2.1 1 0 0 1 1 1 0 Ubiquitin interaction motif DDE_Tnp_1_3 PF13612.6 ELR14487.1 - 0.13 12.3 0.0 0.26 11.3 0.0 1.5 1 1 0 1 1 1 0 Transposase DDE domain SNF5 PF04855.12 ELR14488.1 - 2.9e-33 115.6 1.5 1.2e-22 80.9 1.4 4.7 3 2 0 3 3 3 2 SNF5 / SMARCB1 / INI1 E1_DerP2_DerF2 PF02221.15 ELR14489.1 - 8.9e-19 68.2 0.1 1.4e-18 67.6 0.1 1.3 1 0 0 1 1 1 1 ML domain Mpv17_PMP22 PF04117.12 ELR14490.1 - 5.4e-26 90.6 0.2 8.3e-26 90.0 0.2 1.3 1 0 0 1 1 1 1 Mpv17 / PMP22 family UCR_Fe-S_N PF10399.9 ELR14490.1 - 0.17 11.2 1.0 4.7 6.6 1.0 2.5 1 1 0 1 1 1 0 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal PBP_like_2 PF12849.7 ELR14493.1 - 8.3e-29 101.1 0.7 3.2e-27 95.9 0.1 2.3 2 1 0 2 2 2 1 PBP superfamily domain DASH_Dad1 PF08649.10 ELR14493.1 - 1.9e-07 31.2 0.1 3.1e-07 30.5 0.1 1.4 1 0 0 1 1 1 1 DASH complex subunit Dad1 DASH_Dam1 PF08653.10 ELR14493.1 - 0.042 13.7 0.0 0.083 12.7 0.0 1.4 1 0 0 1 1 1 0 DASH complex subunit Dam1 DASH_Dad4 PF08650.10 ELR14493.1 - 0.049 13.6 0.0 0.089 12.8 0.0 1.3 1 0 0 1 1 1 0 DASH complex subunit Dad4 ABC_tran_2 PF16949.5 ELR14493.1 - 0.18 10.6 0.0 0.26 10.1 0.0 1.1 1 0 0 1 1 1 0 Putative ATP-binding cassette F-box-like PF12937.7 ELR14494.1 - 2.4e-07 30.5 0.0 6.4e-07 29.2 0.0 1.8 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ELR14494.1 - 0.00029 20.6 0.0 0.00081 19.2 0.0 1.8 1 0 0 1 1 1 1 F-box domain ISN1 PF06437.11 ELR14494.1 - 0.1 11.5 0.0 0.14 11.0 0.0 1.1 1 0 0 1 1 1 0 IMP-specific 5'-nucleotidase RRM_1 PF00076.22 ELR14495.1 - 2.8e-16 59.1 0.0 3.8e-16 58.7 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DNA_ligase_IV PF11411.8 ELR14495.1 - 0.084 13.0 0.1 6 7.1 0.0 2.3 2 0 0 2 2 2 0 DNA ligase IV IF-2B PF01008.17 ELR14496.1 - 2.8e-57 194.1 0.1 3.9e-57 193.6 0.1 1.2 1 0 0 1 1 1 1 Initiation factor 2 subunit family Gp_dh_C PF02800.20 ELR14496.1 - 0.023 14.3 0.2 0.07 12.7 0.0 1.8 2 0 0 2 2 2 0 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain FGGY_N PF00370.21 ELR14497.1 - 1.5e-67 227.8 0.0 2e-67 227.3 0.0 1.2 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain FGGY_C PF02782.16 ELR14497.1 - 5.5e-53 179.6 1.6 5.5e-53 179.6 1.6 2.4 3 0 0 3 3 3 1 FGGY family of carbohydrate kinases, C-terminal domain Response_reg PF00072.24 ELR14498.1 - 1.6e-24 86.2 0.0 3.5e-24 85.1 0.0 1.6 1 0 0 1 1 1 1 Response regulator receiver domain HATPase_c PF02518.26 ELR14498.1 - 3.3e-23 82.3 0.0 7.6e-23 81.2 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 ELR14498.1 - 3.7e-15 55.7 0.6 2.6e-14 53.0 0.0 2.6 3 0 0 3 3 3 1 His Kinase A (phospho-acceptor) domain DUF3446 PF11928.8 ELR14498.1 - 0.013 15.8 7.0 0.94 9.8 6.0 2.5 2 0 0 2 2 2 0 Early growth response N-terminal domain ABC2_membrane_5 PF13346.6 ELR14498.1 - 0.097 12.2 3.3 2.8 7.5 0.0 2.1 2 0 0 2 2 2 0 ABC-2 family transporter protein Ank_3 PF13606.6 ELR14499.1 - 6.1e-09 35.4 0.6 0.0097 16.4 0.2 3.7 3 0 0 3 3 3 2 Ankyrin repeat Ank_2 PF12796.7 ELR14499.1 - 1.6e-08 35.0 0.2 9.8e-06 26.1 0.0 2.4 1 1 1 2 2 2 1 Ankyrin repeats (3 copies) Ank PF00023.30 ELR14499.1 - 3.7e-06 27.1 1.1 0.11 13.0 0.1 4.0 4 0 0 4 4 4 1 Ankyrin repeat Ank_4 PF13637.6 ELR14499.1 - 8.5e-06 26.2 0.2 0.00039 20.9 0.1 2.6 2 1 0 2 2 2 1 Ankyrin repeats (many copies) Ank_5 PF13857.6 ELR14499.1 - 0.00089 19.5 0.5 0.064 13.6 0.1 2.7 3 0 0 3 3 2 1 Ankyrin repeats (many copies) RR_TM4-6 PF06459.12 ELR14499.1 - 0.0075 16.1 17.2 0.0095 15.8 17.2 1.1 1 0 0 1 1 1 1 Ryanodine Receptor TM 4-6 SLC12 PF03522.15 ELR14499.1 - 0.019 14.0 12.3 0.024 13.7 12.3 1.1 1 0 0 1 1 1 0 Solute carrier family 12 IFT57 PF10498.9 ELR14499.1 - 0.053 12.5 13.7 0.068 12.1 13.7 1.1 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 PTPRCAP PF15713.5 ELR14499.1 - 0.067 13.5 17.7 0.11 12.8 17.7 1.3 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated SAPS PF04499.15 ELR14499.1 - 0.097 11.4 10.2 0.12 11.1 10.2 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Hid1 PF12722.7 ELR14499.1 - 0.18 9.9 7.6 0.2 9.7 7.6 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein WDCP PF15390.6 ELR14499.1 - 0.23 9.8 7.6 0.28 9.5 7.6 1.0 1 0 0 1 1 1 0 WD repeat and coiled-coil-containing protein family CDC45 PF02724.14 ELR14499.1 - 0.26 9.5 21.3 0.36 9.0 21.3 1.2 1 0 0 1 1 1 0 CDC45-like protein DUF2151 PF10221.9 ELR14499.1 - 0.3 9.6 11.7 0.38 9.3 11.7 1.1 1 0 0 1 1 1 0 Cell cycle and development regulator Vfa1 PF08432.10 ELR14499.1 - 0.38 11.1 23.3 0.58 10.5 23.3 1.2 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Trypan_PARP PF05887.11 ELR14499.1 - 0.48 10.4 10.6 0.68 9.9 10.6 1.2 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) Menin PF05053.13 ELR14499.1 - 0.65 8.3 9.3 0.79 8.0 9.3 1.1 1 0 0 1 1 1 0 Menin DUF913 PF06025.12 ELR14499.1 - 0.71 8.8 11.4 0.97 8.3 11.4 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) CDC27 PF09507.10 ELR14499.1 - 0.73 9.1 30.4 0.92 8.8 30.4 1.0 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 FAM60A PF15396.6 ELR14499.1 - 0.85 9.6 12.1 1.2 9.1 12.1 1.2 1 0 0 1 1 1 0 Protein Family FAM60A CobT PF06213.12 ELR14499.1 - 1 8.7 20.7 1.5 8.1 20.7 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT AAA_11 PF13086.6 ELR14499.1 - 1.2 8.9 11.8 1.7 8.4 11.8 1.2 1 0 0 1 1 1 0 AAA domain Zip PF02535.22 ELR14499.1 - 2.4 7.3 12.4 3.3 6.8 12.4 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Raftlin PF15250.6 ELR14499.1 - 2.7 6.7 11.7 3.6 6.2 11.7 1.1 1 0 0 1 1 1 0 Raftlin Serinc PF03348.15 ELR14499.1 - 2.8 6.8 3.7 3.8 6.3 3.7 1.3 1 0 0 1 1 1 0 Serine incorporator (Serinc) PPP4R2 PF09184.11 ELR14499.1 - 2.9 7.4 23.9 3.9 7.0 23.9 1.1 1 0 0 1 1 1 0 PPP4R2 PA26 PF04636.13 ELR14499.1 - 3 6.7 6.8 3.9 6.3 6.8 1.1 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Presenilin PF01080.17 ELR14499.1 - 3.9 6.1 17.5 5 5.8 17.5 1.1 1 0 0 1 1 1 0 Presenilin TRAP_alpha PF03896.16 ELR14499.1 - 5.6 6.1 10.7 8.5 5.5 10.7 1.3 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Tim54 PF11711.8 ELR14499.1 - 6.9 5.3 15.3 11 4.7 15.3 1.3 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 TP53IP5 PF15331.6 ELR14499.1 - 8.3 6.5 13.5 12 5.9 13.5 1.3 1 0 0 1 1 1 0 Cellular tumour antigen p53-inducible 5 NPR3 PF03666.13 ELR14499.1 - 9.9 4.8 21.0 13 4.4 21.0 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 RRM_1 PF00076.22 ELR14500.1 - 1.9e-14 53.2 0.0 2.5e-14 52.9 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DNA_ligase_IV PF11411.8 ELR14500.1 - 0.012 15.7 0.1 2.1 8.5 0.0 2.3 2 0 0 2 2 2 0 DNA ligase IV RRM_7 PF16367.5 ELR14500.1 - 0.16 12.1 0.0 0.31 11.2 0.0 1.5 1 1 0 1 1 1 0 RNA recognition motif Actin PF00022.19 ELR14501.1 - 5.1e-53 180.1 0.0 8e-46 156.4 0.0 3.0 1 1 1 2 2 2 2 Actin MatP_C PF17414.2 ELR14501.1 - 0.048 13.8 0.0 2.1 8.6 0.0 2.3 2 0 0 2 2 2 0 MatP C-terminal ribbon-helix-helix domain WW_FCH_linker PF16623.5 ELR14502.1 - 0.39 11.5 7.1 22 5.9 7.1 2.1 1 1 0 1 1 1 0 Unstructured linker region between on GAS7 protein Ank_2 PF12796.7 ELR14503.1 - 2.1e-17 63.5 0.0 8.9e-06 26.2 0.0 3.6 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_3 PF13606.6 ELR14503.1 - 7e-15 53.7 1.1 0.0087 16.5 0.2 7.1 7 0 0 7 7 6 2 Ankyrin repeat Ank_4 PF13637.6 ELR14503.1 - 7.9e-12 45.5 0.4 0.00059 20.4 0.1 4.2 3 2 0 3 3 3 3 Ankyrin repeats (many copies) F-box-like PF12937.7 ELR14503.1 - 8.7e-07 28.7 0.1 2e-06 27.6 0.1 1.7 1 0 0 1 1 1 1 F-box-like Ank PF00023.30 ELR14503.1 - 8.6e-06 26.0 8.2 0.11 13.0 0.1 6.6 8 1 0 8 8 6 1 Ankyrin repeat Ank_5 PF13857.6 ELR14503.1 - 2.6e-05 24.4 0.6 0.15 12.4 0.1 4.8 4 1 1 5 5 5 1 Ankyrin repeats (many copies) F-box_5 PF18511.1 ELR14503.1 - 0.00034 20.1 0.0 0.00063 19.3 0.0 1.4 1 0 0 1 1 1 1 F-box SLC12 PF03522.15 ELR14503.1 - 0.074 12.1 10.1 0.11 11.5 10.1 1.1 1 0 0 1 1 1 0 Solute carrier family 12 WDCP PF15390.6 ELR14503.1 - 0.61 8.4 5.8 0.82 8.0 5.8 1.1 1 0 0 1 1 1 0 WD repeat and coiled-coil-containing protein family RR_TM4-6 PF06459.12 ELR14503.1 - 0.68 9.7 19.6 0.14 12.0 16.4 1.4 2 0 0 2 2 1 0 Ryanodine Receptor TM 4-6 SAPS PF04499.15 ELR14503.1 - 0.82 8.4 9.1 1.1 7.9 9.1 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein IFT57 PF10498.9 ELR14503.1 - 1 8.2 13.6 1.5 7.7 13.6 1.1 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 PTPRCAP PF15713.5 ELR14503.1 - 1.1 9.5 19.6 0.27 11.5 15.6 1.9 2 0 0 2 2 2 0 Protein tyrosine phosphatase receptor type C-associated Trypan_PARP PF05887.11 ELR14503.1 - 1.6 8.7 10.8 2.8 7.9 10.8 1.3 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) DUF2151 PF10221.9 ELR14503.1 - 1.7 7.1 9.2 2.3 6.7 9.2 1.1 1 0 0 1 1 1 0 Cell cycle and development regulator Vfa1 PF08432.10 ELR14503.1 - 1.8 8.8 21.6 3.5 7.9 21.6 1.4 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 YABBY PF04690.13 ELR14503.1 - 2.1 8.9 5.0 3.9 8.0 5.0 1.4 1 0 0 1 1 1 0 YABBY protein DUF913 PF06025.12 ELR14503.1 - 2.3 7.1 9.0 3.5 6.5 9.0 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) CDC27 PF09507.10 ELR14503.1 - 3.8 6.8 26.9 5.7 6.2 26.9 1.2 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 RNA_pol_Rpc4 PF05132.14 ELR14503.1 - 4.3 7.8 13.8 11 6.5 13.8 1.7 1 0 0 1 1 1 0 RNA polymerase III RPC4 CDC45 PF02724.14 ELR14503.1 - 4.6 5.4 20.5 7.6 4.7 20.5 1.3 1 0 0 1 1 1 0 CDC45-like protein Zip PF02535.22 ELR14503.1 - 4.6 6.3 11.6 7 5.8 11.6 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Raftlin PF15250.6 ELR14503.1 - 5.2 5.7 9.8 7.5 5.2 9.8 1.1 1 0 0 1 1 1 0 Raftlin Menin PF05053.13 ELR14503.1 - 5.6 5.2 8.8 7.8 4.7 8.8 1.1 1 0 0 1 1 1 0 Menin RRN3 PF05327.11 ELR14503.1 - 8.4 4.8 9.4 12 4.3 9.4 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 CobT PF06213.12 ELR14503.1 - 9 5.6 19.5 15 4.8 19.5 1.3 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Hid1 PF12722.7 ELR14503.1 - 9.4 4.2 9.2 13 3.8 9.2 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein AAA_33 PF13671.6 ELR14504.1 - 3e-17 63.1 0.4 4.8e-14 52.7 0.4 2.2 1 1 0 1 1 1 1 AAA domain KTI12 PF08433.10 ELR14504.1 - 9.1e-10 38.4 0.5 1.3e-07 31.4 0.5 2.1 1 1 0 1 1 1 1 Chromatin associated protein KTI12 Zeta_toxin PF06414.12 ELR14504.1 - 2.1e-08 33.7 0.1 1.6e-06 27.6 0.0 2.2 1 1 1 2 2 2 1 Zeta toxin AAA_18 PF13238.6 ELR14504.1 - 2.5e-07 31.3 0.4 3.5e-05 24.4 0.4 2.2 1 1 0 1 1 1 1 AAA domain tRNA_lig_kinase PF08303.11 ELR14504.1 - 1.3e-05 25.4 0.0 1.8e-05 24.9 0.0 1.2 1 0 0 1 1 1 1 tRNA ligase kinase domain AAA_17 PF13207.6 ELR14504.1 - 5.8e-05 23.5 0.6 0.31 11.5 0.0 2.3 1 1 1 2 2 2 2 AAA domain APS_kinase PF01583.20 ELR14504.1 - 0.00034 20.6 0.1 0.0039 17.1 0.0 2.2 1 1 1 2 2 2 1 Adenylylsulphate kinase Thymidylate_kin PF02223.17 ELR14504.1 - 0.00091 19.0 0.3 0.29 10.8 0.1 2.9 2 1 0 2 2 2 1 Thymidylate kinase AAA_16 PF13191.6 ELR14504.1 - 0.0021 18.5 0.9 0.017 15.5 0.9 2.0 1 1 0 1 1 1 1 AAA ATPase domain CPT PF07931.12 ELR14504.1 - 0.0028 17.5 0.0 0.0064 16.3 0.0 1.7 1 1 0 1 1 1 1 Chloramphenicol phosphotransferase-like protein AAA PF00004.29 ELR14504.1 - 0.012 16.0 0.0 0.023 15.1 0.0 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_25 PF13481.6 ELR14504.1 - 0.013 15.1 0.5 0.031 13.9 0.5 2.1 1 1 0 1 1 1 0 AAA domain AAA_5 PF07728.14 ELR14504.1 - 0.016 15.2 0.0 0.024 14.6 0.0 1.3 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) 6PF2K PF01591.18 ELR14504.1 - 0.018 14.4 0.0 0.027 13.8 0.0 1.4 1 1 0 1 1 1 0 6-phosphofructo-2-kinase AAA_24 PF13479.6 ELR14504.1 - 0.022 14.5 0.1 0.037 13.7 0.1 1.5 1 1 0 1 1 1 0 AAA domain dNK PF01712.19 ELR14504.1 - 0.026 14.4 0.5 3.5 7.4 0.0 2.9 1 1 1 2 2 2 0 Deoxynucleoside kinase NB-ARC PF00931.22 ELR14504.1 - 0.027 13.6 0.1 0.057 12.6 0.1 1.4 1 1 0 1 1 1 0 NB-ARC domain AAA_28 PF13521.6 ELR14504.1 - 0.065 13.5 0.1 0.22 11.7 0.1 1.8 1 1 0 1 1 1 0 AAA domain ATP_bind_2 PF03668.15 ELR14504.1 - 0.081 12.2 0.0 0.1 11.8 0.0 1.1 1 0 0 1 1 1 0 P-loop ATPase protein family SKI PF01202.22 ELR14504.1 - 0.082 13.0 0.2 0.78 9.8 0.2 2.1 1 1 0 1 1 1 0 Shikimate kinase Mg_chelatase PF01078.21 ELR14504.1 - 0.084 12.2 0.0 0.22 10.9 0.0 1.7 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI cobW PF02492.19 ELR14504.1 - 0.13 11.8 0.0 0.19 11.3 0.0 1.5 1 1 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain Viral_helicase1 PF01443.18 ELR14504.1 - 0.14 11.9 0.0 0.31 10.8 0.0 1.6 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase RNA_helicase PF00910.22 ELR14504.1 - 0.14 12.5 0.0 0.23 11.9 0.0 1.4 1 0 0 1 1 1 0 RNA helicase AAA_22 PF13401.6 ELR14504.1 - 0.16 12.3 0.1 0.47 10.7 0.1 1.8 1 1 0 1 1 1 0 AAA domain LicD PF04991.13 ELR14505.1 - 1.3e-07 32.0 5.7 2.2e-07 31.2 3.3 2.3 3 0 0 3 3 3 1 LicD family PH PF00169.29 ELR14506.1 - 1.6e-17 63.9 0.1 7.9e-17 61.7 0.1 2.2 2 0 0 2 2 2 1 PH domain LRR_6 PF13516.6 ELR14506.1 - 1.8e-08 33.7 12.3 1.3 9.2 0.0 7.0 7 0 0 7 7 7 5 Leucine Rich repeat PH_8 PF15409.6 ELR14506.1 - 1.2e-07 31.9 0.2 2.8e-07 30.7 0.2 1.6 1 0 0 1 1 1 1 Pleckstrin homology domain PH_3 PF14593.6 ELR14506.1 - 1.3e-05 25.2 0.1 2.9e-05 24.1 0.1 1.5 1 0 0 1 1 1 1 PH domain PH_11 PF15413.6 ELR14506.1 - 0.00014 22.2 2.4 0.001 19.4 2.4 2.3 1 1 0 1 1 1 1 Pleckstrin homology domain LRR_1 PF00560.33 ELR14506.1 - 0.0041 17.5 8.8 83 4.4 0.0 6.7 6 0 0 6 6 6 0 Leucine Rich Repeat FTH PF01827.27 ELR14506.1 - 0.025 14.4 0.4 0.079 12.7 0.4 2.0 1 0 0 1 1 1 0 FTH domain LRR_4 PF12799.7 ELR14506.1 - 1.9 9.0 18.0 1.2 9.6 1.7 5.5 3 3 3 6 6 6 0 Leucine Rich repeats (2 copies) Mito_carr PF00153.27 ELR14507.1 - 3.9e-17 62.0 2.8 1.5e-07 31.2 0.0 3.6 3 1 0 3 3 3 3 Mitochondrial carrier protein KxDL PF10241.9 ELR14509.1 - 2.2e-16 59.9 2.0 3.8e-16 59.1 2.0 1.3 1 0 0 1 1 1 1 Uncharacterized conserved protein DUF4743 PF15916.5 ELR14509.1 - 0.027 14.4 0.6 0.077 13.0 0.6 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4743) Tweety PF04906.13 ELR14509.1 - 0.051 12.3 0.1 0.069 11.8 0.1 1.1 1 0 0 1 1 1 0 Tweety CorA PF01544.18 ELR14509.1 - 0.13 11.5 0.4 0.2 10.9 0.4 1.2 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein Nop16 PF09420.10 ELR14509.1 - 2.3 8.2 16.8 5 7.1 16.8 1.6 1 0 0 1 1 1 0 Ribosome biogenesis protein Nop16 Metallophos PF00149.28 ELR14510.1 - 4.4e-06 27.3 0.0 8.7e-06 26.4 0.0 1.5 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos PF00149.28 ELR14511.1 - 0.00029 21.4 0.1 0.001 19.6 0.1 1.9 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase PGA_cap PF09587.10 ELR14511.1 - 0.014 14.9 0.2 0.25 10.7 0.1 2.1 1 1 1 2 2 2 0 Bacterial capsule synthesis protein PGA_cap Metallophos_2 PF12850.7 ELR14511.1 - 0.032 14.4 0.1 0.53 10.5 0.1 2.4 1 1 0 1 1 1 0 Calcineurin-like phosphoesterase superfamily domain Tautomerase PF01361.21 ELR14511.1 - 0.065 13.2 0.4 0.14 12.1 0.0 1.7 2 0 0 2 2 2 0 Tautomerase enzyme hemP PF10636.9 ELR14511.1 - 0.11 12.3 0.0 0.21 11.4 0.0 1.4 1 0 0 1 1 1 0 Hemin uptake protein hemP CAP_N PF01213.19 ELR14511.1 - 0.53 9.7 4.1 0.87 9.0 4.1 1.3 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal Metallophos PF00149.28 ELR14512.1 - 1.8e-06 28.6 0.0 3.5e-06 27.7 0.0 1.4 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase RasGEF PF00617.19 ELR14513.1 - 1.2e-43 149.4 0.2 2.2e-43 148.5 0.2 1.4 1 0 0 1 1 1 1 RasGEF domain Cupin_8 PF13621.6 ELR14514.1 - 1.2e-17 64.5 2.3 2.9e-14 53.4 1.2 2.2 1 1 1 2 2 2 2 Cupin-like domain Cupin_4 PF08007.12 ELR14514.1 - 3e-09 36.8 0.0 6.4e-09 35.7 0.0 1.6 1 1 0 1 1 1 1 Cupin superfamily protein JmjC PF02373.22 ELR14514.1 - 0.00011 22.6 0.1 0.00024 21.5 0.1 1.6 1 1 0 1 1 1 1 JmjC domain, hydroxylase Cupin_2 PF07883.11 ELR14514.1 - 0.021 14.5 0.0 0.053 13.2 0.0 1.7 1 0 0 1 1 1 0 Cupin domain AraC_binding PF02311.19 ELR14514.1 - 0.054 13.4 0.2 0.15 12.0 0.2 1.8 1 1 0 1 1 1 0 AraC-like ligand binding domain RskA PF10099.9 ELR14514.1 - 0.19 12.0 2.3 0.44 10.8 2.3 1.5 1 0 0 1 1 1 0 Anti-sigma-K factor rskA Serinc PF03348.15 ELR14515.1 - 2.4e-125 418.9 7.7 2.7e-125 418.7 7.7 1.0 1 0 0 1 1 1 1 Serine incorporator (Serinc) Sep15_SelM PF08806.11 ELR14516.1 - 1.4e-07 31.6 0.1 8.3e-07 29.1 0.0 2.0 2 0 0 2 2 2 1 Sep15/SelM redox domain ubiquitin PF00240.23 ELR14518.1 - 3e-47 158.3 1.0 7.2e-23 80.1 0.3 2.0 2 0 0 2 2 2 2 Ubiquitin family Rad60-SLD PF11976.8 ELR14518.1 - 5.6e-18 64.5 0.5 3.4e-09 36.4 0.0 2.0 2 0 0 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 ELR14518.1 - 4.1e-07 30.4 2.8 0.00028 21.3 0.1 3.3 2 2 0 2 2 2 1 Ubiquitin-like domain Ubiquitin_4 PF18036.1 ELR14518.1 - 0.00011 22.2 5.0 2.4 8.2 0.1 4.0 3 1 1 4 4 4 2 Ubiquitin-like domain Ubiquitin_5 PF18037.1 ELR14518.1 - 0.00063 20.1 0.1 0.003 17.9 0.0 1.9 2 1 0 2 2 2 1 Ubiquitin-like domain DUF2407 PF10302.9 ELR14518.1 - 0.00072 20.1 0.1 0.098 13.2 0.0 2.2 2 0 0 2 2 2 1 DUF2407 ubiquitin-like domain TBK1_ULD PF18396.1 ELR14518.1 - 0.003 17.5 0.3 0.2 11.6 0.0 2.2 2 0 0 2 2 2 1 TANK binding kinase 1 ubiquitin-like domain Rad60-SLD_2 PF13881.6 ELR14518.1 - 0.01 15.9 0.1 0.45 10.7 0.0 2.7 1 1 1 2 2 2 0 Ubiquitin-2 like Rad60 SUMO-like Plexin_cytopl PF08337.12 ELR14518.1 - 0.022 13.4 2.5 2 7.0 0.3 3.2 2 1 1 3 3 3 0 Plexin cytoplasmic RasGAP domain DUF4361 PF14274.6 ELR14518.1 - 0.046 14.0 0.0 0.075 13.3 0.0 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4361) DUF2870 PF11069.8 ELR14518.1 - 0.06 13.7 0.0 2 8.8 0.0 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF2870) GDPD PF03009.17 ELR14519.1 - 2.1e-26 93.2 0.0 3.1e-26 92.6 0.0 1.3 1 0 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family GDPD_2 PF13653.6 ELR14519.1 - 0.0095 16.4 0.1 0.039 14.4 0.0 2.2 2 0 0 2 2 2 1 Glycerophosphoryl diester phosphodiesterase family Macro PF01661.21 ELR14520.1 - 4.9e-30 104.0 0.0 6.7e-30 103.6 0.0 1.2 1 0 0 1 1 1 1 Macro domain DEAD PF00270.29 ELR14521.1 - 9.5e-33 113.4 0.0 1.5e-32 112.7 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ELR14521.1 - 2e-21 76.4 0.0 5.1e-21 75.1 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain AAA_22 PF13401.6 ELR14521.1 - 0.015 15.6 0.2 0.054 13.8 0.2 1.9 1 1 0 1 1 1 0 AAA domain AAA_30 PF13604.6 ELR14521.1 - 0.016 15.0 0.2 0.016 15.0 0.2 2.2 2 0 0 2 2 2 0 AAA domain AAA PF00004.29 ELR14521.1 - 0.024 15.1 0.0 0.077 13.4 0.0 1.8 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) TniB PF05621.11 ELR14521.1 - 0.076 12.4 0.1 0.87 9.0 0.0 2.2 2 0 0 2 2 2 0 Bacterial TniB protein WD40 PF00400.32 ELR14522.1 - 2.2e-19 69.4 13.4 0.00075 20.3 0.0 6.8 6 1 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ELR14522.1 - 1.9e-09 37.7 0.0 0.0066 16.7 0.1 3.8 2 2 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ELR14522.1 - 0.0043 16.1 0.1 2.1 7.2 0.0 2.2 2 0 0 2 2 2 2 WD40 region of Ge1, enhancer of mRNA-decapping protein DUF3682 PF12446.8 ELR14523.1 - 0.1 13.0 8.8 0.17 12.3 8.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3682) Pox_Ag35 PF03286.14 ELR14523.1 - 0.9 9.3 8.9 1.3 8.8 8.9 1.2 1 0 0 1 1 1 0 Pox virus Ag35 surface protein CDC45 PF02724.14 ELR14523.1 - 4.4 5.5 9.1 5.2 5.2 9.1 1.2 1 0 0 1 1 1 0 CDC45-like protein DnaJ PF00226.31 ELR14524.1 - 1.5e-15 57.1 0.2 5.4e-15 55.3 0.1 1.8 2 0 0 2 2 2 1 DnaJ domain MLTR_LBD PF17765.1 ELR14524.1 - 0.00067 19.8 0.6 0.00082 19.5 0.6 1.0 1 0 0 1 1 1 1 MmyB-like transcription regulator ligand binding domain RGS PF00615.19 ELR14525.1 - 3.2e-27 95.1 0.7 4.5e-27 94.7 0.7 1.1 1 0 0 1 1 1 1 Regulator of G protein signaling domain Sterol_MT_C PF08498.10 ELR14527.1 - 8.3e-27 93.3 0.1 1.6e-26 92.3 0.1 1.5 1 0 0 1 1 1 1 Sterol methyltransferase C-terminal Methyltransf_11 PF08241.12 ELR14527.1 - 1.2e-18 67.6 0.0 2.3e-18 66.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ELR14527.1 - 1.4e-14 54.5 0.0 3.2e-14 53.4 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 ELR14527.1 - 3.7e-12 46.4 0.0 6.1e-12 45.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ELR14527.1 - 2.6e-11 43.5 0.0 3.8e-11 43.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 ELR14527.1 - 3.6e-11 42.9 0.0 5.3e-11 42.3 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Ubie_methyltran PF01209.18 ELR14527.1 - 7.1e-09 35.3 0.0 1.3e-08 34.5 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_12 PF08242.12 ELR14527.1 - 6.7e-08 33.2 0.1 2.3e-07 31.4 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain PCMT PF01135.19 ELR14527.1 - 0.00085 19.1 0.0 0.0021 17.8 0.0 1.6 2 0 0 2 2 2 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) MTS PF05175.14 ELR14527.1 - 0.013 15.1 0.0 0.03 13.9 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase small domain ChuX_HutX PF06228.13 ELR14527.1 - 0.13 12.0 0.0 0.36 10.6 0.0 1.7 2 0 0 2 2 2 0 Haem utilisation ChuX/HutX UPF0020 PF01170.18 ELR14527.1 - 0.16 11.7 0.0 0.26 11.0 0.0 1.3 1 0 0 1 1 1 0 Putative RNA methylase family UPF0020 DMRL_synthase PF00885.19 ELR14530.1 - 7e-40 136.1 0.1 8.3e-40 135.9 0.1 1.1 1 0 0 1 1 1 1 6,7-dimethyl-8-ribityllumazine synthase NDUF_B6 PF09782.9 ELR14530.1 - 0.081 13.1 0.0 0.11 12.7 0.0 1.2 1 0 0 1 1 1 0 NADH:ubiquinone oxidoreductase, NDUFB6/B17 subunit Mpv17_PMP22 PF04117.12 ELR14531.1 - 2.4e-14 53.3 4.2 4.8e-14 52.3 4.2 1.5 1 0 0 1 1 1 1 Mpv17 / PMP22 family Nop14 PF04147.12 ELR14534.1 - 3.1 5.9 31.6 4 5.5 31.6 1.2 1 0 0 1 1 1 0 Nop14-like family RVT_2 PF07727.14 ELR14536.1 - 5.4e-20 72.1 0.2 4.8e-18 65.7 0.2 2.0 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF1235 PF06822.12 ELR14536.1 - 0.014 14.7 0.7 0.02 14.2 0.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1235) RVT_2 PF07727.14 ELR14537.1 - 1e-07 31.9 0.0 1.8e-07 31.1 0.0 1.5 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) 2_5_RNA_ligase2 PF13563.6 ELR14540.1 - 7.2e-21 74.7 1.7 1.7e-18 67.0 0.6 2.7 1 1 1 2 2 2 2 2'-5' RNA ligase superfamily RRM_1 PF00076.22 ELR14540.1 - 4.7e-07 29.5 0.1 1.7e-06 27.7 0.1 2.0 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Pinin_SDK_N PF04697.13 ELR14540.1 - 0.028 15.1 0.7 0.055 14.1 0.7 1.5 1 0 0 1 1 1 0 pinin/SDK conserved region LigT_PEase PF02834.16 ELR14540.1 - 0.093 12.9 1.3 0.5 10.6 0.0 2.9 4 0 0 4 4 4 0 LigT like Phosphoesterase DDE_Tnp_1_7 PF13843.6 ELR14545.1 - 2.1e-15 56.9 1.2 4.1e-08 32.9 0.0 2.0 1 1 1 2 2 2 2 Transposase IS4 Asparaginase_2 PF01112.18 ELR14545.1 - 0.18 10.8 0.0 0.24 10.4 0.0 1.1 1 0 0 1 1 1 0 Asparaginase PB1 PF00564.24 ELR14546.1 - 6e-06 26.1 0.0 1.3e-05 25.1 0.0 1.6 1 0 0 1 1 1 1 PB1 domain B5 PF03484.15 ELR14546.1 - 0.011 16.0 0.2 0.045 14.1 0.2 2.3 1 1 0 1 1 1 0 tRNA synthetase B5 domain SAM_1 PF00536.30 ELR14546.1 - 0.15 12.5 0.1 0.34 11.4 0.1 1.7 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 ELR14547.1 - 1.9e-07 31.1 0.0 2.8e-07 30.5 0.0 1.3 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 ELR14547.1 - 4.6e-06 27.0 0.0 7.2e-06 26.4 0.0 1.3 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) PB1 PF00564.24 ELR14547.1 - 1.1e-05 25.3 0.3 5e-05 23.2 0.1 2.1 2 0 0 2 2 2 1 PB1 domain DNA_pol_phi PF04931.13 ELR14547.1 - 0.12 10.5 13.3 0.18 9.8 13.3 1.2 1 0 0 1 1 1 0 DNA polymerase phi Sigma70_ner PF04546.13 ELR14547.1 - 0.26 11.1 3.2 0.61 9.9 3.2 1.5 1 0 0 1 1 1 0 Sigma-70, non-essential region CENP-B_dimeris PF09026.10 ELR14547.1 - 5.3 7.5 19.6 0.4 11.1 13.1 2.3 2 0 0 2 2 2 0 Centromere protein B dimerisation domain Helicase_C PF00271.31 ELR14548.1 - 1.8e-11 44.4 0.0 2.5e-11 43.9 0.0 1.2 1 0 0 1 1 1 1 Helicase conserved C-terminal domain PARP PF00644.20 ELR14549.1 - 3.2e-23 82.3 0.3 4.7e-23 81.8 0.3 1.3 1 1 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain Helicase_C PF00271.31 ELR14550.1 - 2.1e-08 34.5 0.0 3.2e-08 33.9 0.0 1.3 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Helicase_C PF00271.31 ELR14551.1 - 9.3e-12 45.3 0.0 1.4e-11 44.7 0.0 1.3 1 0 0 1 1 1 1 Helicase conserved C-terminal domain gpW PF02831.15 ELR14551.1 - 0.18 11.8 0.4 6.9 6.6 0.1 2.6 2 0 0 2 2 2 0 gpW Ank_2 PF12796.7 ELR14552.1 - 3.1e-101 332.1 39.2 6.3e-12 45.9 1.8 16.5 10 4 7 18 18 18 14 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ELR14552.1 - 1.2e-86 284.0 33.5 2.2e-10 40.8 0.0 21.6 11 8 11 22 22 22 20 Ankyrin repeats (many copies) Ank_5 PF13857.6 ELR14552.1 - 1.9e-68 225.6 37.8 5.6e-06 26.5 0.0 20.3 14 6 6 20 20 20 15 Ankyrin repeats (many copies) Ank_3 PF13606.6 ELR14552.1 - 5.3e-59 189.2 32.8 0.00057 20.1 0.0 24.7 24 0 0 24 24 24 12 Ankyrin repeat PARP PF00644.20 ELR14552.1 - 2.8e-58 196.7 0.2 2.8e-58 196.7 0.2 3.8 3 0 0 3 3 2 1 Poly(ADP-ribose) polymerase catalytic domain Ank PF00023.30 ELR14552.1 - 1.7e-56 186.3 29.9 4.9e-06 26.7 0.1 22.0 23 1 0 23 23 22 12 Ankyrin repeat PARP_reg PF02877.14 ELR14552.1 - 2.2e-29 102.3 1.2 7.7e-29 100.5 0.3 2.5 2 0 0 2 2 2 1 Poly(ADP-ribose) polymerase, regulatory domain WGR PF05406.15 ELR14552.1 - 1.1e-23 83.0 0.3 1.5e-22 79.4 0.2 3.3 2 0 0 2 2 1 1 WGR domain Nop14 PF04147.12 ELR14552.1 - 4.2e-05 22.0 31.1 4.2e-05 22.0 31.1 7.4 6 2 0 6 6 4 3 Nop14-like family SDA1 PF05285.12 ELR14552.1 - 0.0018 17.8 31.9 0.0018 17.8 31.9 8.5 6 2 0 6 6 4 1 SDA1 TFIIA PF03153.13 ELR14552.1 - 0.0019 18.3 20.9 0.0019 18.3 20.9 6.8 5 1 1 6 6 4 1 Transcription factor IIA, alpha/beta subunit gp45-slide_C PF09116.10 ELR14552.1 - 0.25 11.4 1.3 2.2 8.4 0.2 3.2 3 0 0 3 3 3 0 gp45 sliding clamp, C terminal BES1_N PF05687.13 ELR14553.1 - 1 9.7 3.5 1.2 9.5 3.5 1.0 1 0 0 1 1 1 0 BES1/BZR1 plant transcription factor, N-terminal GTP_EFTU PF00009.27 ELR14554.1 - 1.6e-07 31.0 0.0 4.4e-05 23.1 0.0 2.2 2 0 0 2 2 2 2 Elongation factor Tu GTP binding domain F-box-like PF12937.7 ELR14554.1 - 1e-06 28.5 0.4 2.6e-06 27.2 0.2 1.8 2 0 0 2 2 2 1 F-box-like GTP_EFTU_D3 PF03143.17 ELR14554.1 - 2.9e-05 24.4 0.1 0.0029 17.9 0.0 2.4 1 1 1 2 2 2 1 Elongation factor Tu C-terminal domain RsgA_GTPase PF03193.16 ELR14554.1 - 0.00087 19.2 0.0 0.097 12.6 0.0 2.3 2 0 0 2 2 2 1 RsgA GTPase G-alpha PF00503.20 ELR14554.1 - 0.036 13.2 0.0 0.053 12.7 0.0 1.2 1 0 0 1 1 1 0 G-protein alpha subunit AAA_29 PF13555.6 ELR14554.1 - 0.075 12.8 0.0 0.18 11.6 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain RVP_2 PF08284.11 ELR14556.1 - 0.026 14.3 0.0 0.046 13.5 0.0 1.4 1 0 0 1 1 1 0 Retroviral aspartyl protease RT_RNaseH_2 PF17919.1 ELR14557.1 - 4.9e-31 106.7 0.9 8.9e-31 105.9 0.9 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 ELR14557.1 - 3.7e-20 72.2 0.4 7.2e-20 71.2 0.4 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 ELR14557.1 - 2e-15 56.9 0.2 1.2e-14 54.4 0.1 2.0 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) Integrase_H2C2 PF17921.1 ELR14558.1 - 4.9e-19 68.2 0.8 1.2e-18 66.9 0.8 1.7 1 0 0 1 1 1 1 Integrase zinc binding domain rve PF00665.26 ELR14558.1 - 1.1e-15 57.9 0.1 3.4e-15 56.3 0.0 1.8 2 0 0 2 2 2 1 Integrase core domain rve_3 PF13683.6 ELR14558.1 - 0.0014 18.3 0.1 0.0055 16.4 0.0 2.1 2 0 0 2 2 2 1 Integrase core domain DUF346 PF03984.13 ELR14558.1 - 1.5 8.6 7.9 1.3 8.8 1.2 2.8 2 0 0 2 2 2 0 Repeat of unknown function (DUF346) Trypsin_2 PF13365.6 ELR14561.1 - 0.093 13.6 0.1 0.15 12.9 0.1 1.4 1 0 0 1 1 1 0 Trypsin-like peptidase domain GST_N_3 PF13417.6 ELR14562.1 - 1.1e-12 48.2 0.0 2.3e-12 47.1 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 ELR14562.1 - 2.7e-09 36.9 0.4 5.8e-09 35.8 0.4 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_4 PF17172.4 ELR14562.1 - 2.1e-05 25.2 0.0 0.00033 21.3 0.0 2.7 3 1 0 3 3 3 1 Glutathione S-transferase N-terminal domain GST_C PF00043.25 ELR14562.1 - 3.5e-05 23.9 0.0 6.4e-05 23.1 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.6 ELR14562.1 - 0.0022 18.3 0.0 0.0068 16.7 0.0 1.9 1 1 0 1 1 1 1 Glutathione S-transferase, N-terminal domain ATG27 PF09451.10 ELR14563.1 - 3.9e-17 63.0 0.0 5.6e-17 62.5 0.0 1.1 1 0 0 1 1 1 1 Autophagy-related protein 27 CIMR PF00878.18 ELR14563.1 - 4.4e-08 33.3 0.2 0.00042 20.4 0.3 2.2 2 0 0 2 2 2 2 Cation-independent mannose-6-phosphate receptor repeat Man-6-P_recep PF02157.15 ELR14563.1 - 1.7e-05 24.1 0.4 3.3e-05 23.1 0.4 1.4 1 0 0 1 1 1 1 Mannose-6-phosphate receptor ATG27 PF09451.10 ELR14564.1 - 1.3e-18 67.8 0.0 1.8e-18 67.4 0.0 1.1 1 0 0 1 1 1 1 Autophagy-related protein 27 CIMR PF00878.18 ELR14564.1 - 9.5e-09 35.5 0.1 0.00035 20.7 0.4 2.1 2 0 0 2 2 2 2 Cation-independent mannose-6-phosphate receptor repeat Man-6-P_recep PF02157.15 ELR14564.1 - 3.1e-06 26.5 0.1 5.9e-06 25.6 0.1 1.4 1 0 0 1 1 1 1 Mannose-6-phosphate receptor PIG-P PF08510.12 ELR14564.1 - 0.04 13.8 0.3 0.25 11.2 0.1 2.1 2 0 0 2 2 2 0 PIG-P Patatin PF01734.22 ELR14565.1 - 4.4e-16 59.7 0.0 1.7e-09 38.2 0.0 3.3 3 0 0 3 3 3 2 Patatin-like phospholipase CIMR PF00878.18 ELR14565.1 - 1.3e-07 31.8 0.0 0.00067 19.8 0.1 2.4 2 0 0 2 2 2 2 Cation-independent mannose-6-phosphate receptor repeat ATG27 PF09451.10 ELR14565.1 - 8.4e-07 29.1 1.6 8.6e-07 29.1 0.0 1.9 2 0 0 2 2 2 1 Autophagy-related protein 27 Pro-kuma_activ PF09286.11 ELR14566.1 - 4.5e-20 72.4 0.0 7.6e-20 71.7 0.0 1.3 1 0 0 1 1 1 1 Pro-kumamolisin, activation domain Peptidase_S8 PF00082.22 ELR14566.1 - 0.00012 21.5 3.5 0.0002 20.8 3.5 1.3 1 0 0 1 1 1 1 Subtilase family Pox_T4_N PF04491.12 ELR14566.1 - 0.62 10.0 2.4 0.63 9.9 0.7 1.8 2 0 0 2 2 2 0 Poxvirus T4 protein, N terminus DEP PF00610.21 ELR14567.1 - 1.9e-12 47.0 0.1 3.3e-12 46.3 0.1 1.4 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) DUF547 PF04784.14 ELR14567.1 - 7.2e-07 29.3 0.0 1.5e-06 28.2 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function, DUF547 TM2 PF05154.16 ELR14568.1 - 6.5e-08 32.8 0.7 6.5e-08 32.8 0.7 2.9 3 0 0 3 3 3 1 TM2 domain EGF_2 PF07974.13 ELR14568.1 - 0.0024 18.2 10.1 0.0024 18.2 10.1 1.9 1 1 1 2 2 2 1 EGF-like domain EGF PF00008.27 ELR14568.1 - 0.042 14.1 2.5 0.042 14.1 2.5 2.2 2 1 0 2 2 2 0 EGF-like domain DUF3273 PF11677.8 ELR14568.1 - 0.13 11.6 2.0 0.83 8.9 0.5 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3273) Gelsolin PF00626.22 ELR14569.1 - 4.4e-20 71.4 0.0 4.8e-09 36.0 0.0 2.4 2 0 0 2 2 2 2 Gelsolin repeat PH PF00169.29 ELR14569.1 - 5.2e-17 62.3 0.1 9.7e-17 61.4 0.1 1.5 1 0 0 1 1 1 1 PH domain PH_11 PF15413.6 ELR14569.1 - 1.1e-09 38.6 2.0 1.7e-08 34.8 2.0 2.5 1 1 0 1 1 1 1 Pleckstrin homology domain PH_8 PF15409.6 ELR14569.1 - 8.6e-07 29.1 2.9 2.3e-06 27.8 0.1 2.8 3 0 0 3 3 3 1 Pleckstrin homology domain PH_3 PF14593.6 ELR14569.1 - 1.9e-06 27.9 0.0 3.9e-06 26.9 0.0 1.5 1 0 0 1 1 1 1 PH domain RNR_Alpha PF17975.1 ELR14569.1 - 0.0048 17.3 0.9 0.012 16.1 0.9 1.6 1 0 0 1 1 1 1 Ribonucleotide reductase alpha domain ATP-synt_B PF00430.18 ELR14569.1 - 0.12 12.5 11.4 0.19 11.8 11.4 1.2 1 0 0 1 1 1 0 ATP synthase B/B' CF(0) Flot PF15975.5 ELR14569.1 - 1.2 9.4 11.4 2.5 8.3 11.4 1.5 1 0 0 1 1 1 0 Flotillin CX9C PF16860.5 ELR14570.1 - 0.00015 21.7 2.2 0.44 10.6 0.7 2.3 2 0 0 2 2 2 2 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, CHCH PF06747.13 ELR14570.1 - 0.00037 20.5 1.6 0.56 10.4 0.4 2.5 2 1 0 2 2 2 2 CHCH domain IL12 PF03039.14 ELR14570.1 - 0.082 12.2 0.3 0.11 11.8 0.3 1.2 1 0 0 1 1 1 0 Interleukin-12 alpha subunit Ndufs5 PF10200.9 ELR14570.1 - 0.12 12.6 1.3 0.39 11.0 0.6 2.1 1 1 1 2 2 2 0 NADH:ubiquinone oxidoreductase, NDUFS5-15kDa AlbA_2 PF04326.14 ELR14571.1 - 9e-14 51.9 0.0 2e-13 50.7 0.0 1.6 1 0 0 1 1 1 1 Putative DNA-binding domain RrnaAD PF00398.20 ELR14572.1 - 1.2e-54 185.1 0.0 8.1e-53 179.2 0.0 2.1 1 1 0 1 1 1 1 Ribosomal RNA adenine dimethylase Methyltransf_25 PF13649.6 ELR14572.1 - 2e-08 34.8 0.0 4.4e-08 33.7 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ELR14572.1 - 3.4e-05 24.4 0.0 7.6e-05 23.3 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 ELR14572.1 - 0.0002 21.3 0.0 0.00031 20.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain DREV PF05219.12 ELR14572.1 - 0.00024 20.3 0.0 0.0004 19.6 0.0 1.3 1 0 0 1 1 1 1 DREV methyltransferase NodS PF05401.11 ELR14572.1 - 0.00029 20.5 0.0 0.00051 19.7 0.0 1.3 1 0 0 1 1 1 1 Nodulation protein S (NodS) Methyltransf_12 PF08242.12 ELR14572.1 - 0.00057 20.6 0.0 0.0012 19.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 ELR14572.1 - 0.00072 18.9 0.0 0.0018 17.6 0.0 1.5 2 0 0 2 2 2 1 Mycolic acid cyclopropane synthetase PCMT PF01135.19 ELR14572.1 - 0.0019 18.0 0.0 0.0027 17.5 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Ubie_methyltran PF01209.18 ELR14572.1 - 0.013 14.8 0.0 0.022 14.1 0.0 1.3 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family UPF0020 PF01170.18 ELR14572.1 - 0.04 13.6 0.0 0.066 12.9 0.0 1.4 1 0 0 1 1 1 0 Putative RNA methylase family UPF0020 Methyltransf_4 PF02390.17 ELR14572.1 - 0.041 13.3 0.0 0.067 12.7 0.0 1.3 1 0 0 1 1 1 0 Putative methyltransferase Methyltransf_31 PF13847.6 ELR14572.1 - 0.048 13.5 0.0 0.079 12.7 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain PRMT5 PF05185.16 ELR14572.1 - 0.048 13.5 0.0 0.095 12.5 0.0 1.4 1 0 0 1 1 1 0 PRMT5 arginine-N-methyltransferase Methyltransf_15 PF09445.10 ELR14572.1 - 0.057 13.0 0.0 0.15 11.6 0.0 1.7 2 0 0 2 2 2 0 RNA cap guanine-N2 methyltransferase tRNA_U5-meth_tr PF05958.11 ELR14572.1 - 0.083 11.9 0.0 0.12 11.3 0.0 1.2 1 0 0 1 1 1 0 tRNA (Uracil-5-)-methyltransferase Methyltransf_28 PF02636.17 ELR14572.1 - 0.097 12.3 0.0 0.18 11.4 0.0 1.4 1 0 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase Methyltransf_2 PF00891.18 ELR14572.1 - 0.16 11.2 0.0 0.23 10.7 0.0 1.1 1 0 0 1 1 1 0 O-methyltransferase domain UPRTase PF14681.6 ELR14573.1 - 1.3e-65 220.7 0.0 2e-65 220.1 0.0 1.2 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase PRK PF00485.18 ELR14573.1 - 3.8e-52 176.9 0.1 5.7e-52 176.3 0.1 1.2 1 0 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family AAA_18 PF13238.6 ELR14573.1 - 1.2e-06 29.1 0.0 8.8e-06 26.3 0.0 2.1 2 0 0 2 2 2 1 AAA domain Pribosyltran PF00156.27 ELR14573.1 - 0.00039 20.0 0.0 0.00067 19.2 0.0 1.3 1 0 0 1 1 1 1 Phosphoribosyl transferase domain Cytidylate_kin PF02224.18 ELR14573.1 - 0.0011 18.7 0.2 0.059 13.1 0.0 2.4 2 0 0 2 2 2 1 Cytidylate kinase CoaE PF01121.20 ELR14573.1 - 0.021 14.5 0.1 0.3 10.7 0.0 2.2 2 0 0 2 2 2 0 Dephospho-CoA kinase CPT PF07931.12 ELR14573.1 - 0.022 14.6 0.0 0.043 13.7 0.0 1.5 1 0 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein AAA_33 PF13671.6 ELR14573.1 - 0.036 14.2 0.0 0.15 12.3 0.0 1.9 2 0 0 2 2 2 0 AAA domain Zeta_toxin PF06414.12 ELR14573.1 - 0.038 13.3 0.0 0.077 12.3 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin AAA_17 PF13207.6 ELR14573.1 - 0.11 12.9 0.1 21 5.5 0.0 2.5 2 0 0 2 2 2 0 AAA domain FYVE PF01363.21 ELR14574.1 - 2.3e-18 66.1 8.1 5.4e-18 64.9 8.1 1.7 1 0 0 1 1 1 1 FYVE zinc finger PH PF00169.29 ELR14574.1 - 2.9e-15 56.7 0.0 1.1e-14 54.8 0.0 2.1 1 0 0 1 1 1 1 PH domain SH3_1 PF00018.28 ELR14574.1 - 4.5e-14 51.8 0.2 1.2e-13 50.4 0.2 1.7 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 ELR14574.1 - 5.2e-08 32.6 0.1 3.8e-07 29.9 0.0 2.2 2 0 0 2 2 2 1 Variant SH3 domain PH_11 PF15413.6 ELR14574.1 - 1.1e-07 32.2 0.0 1.1e-07 32.2 0.0 2.6 3 0 0 3 3 3 1 Pleckstrin homology domain SH3_2 PF07653.17 ELR14574.1 - 1.2e-07 31.2 0.1 3.4e-07 29.9 0.0 1.8 2 0 0 2 2 2 1 Variant SH3 domain PH_8 PF15409.6 ELR14574.1 - 2e-06 28.0 0.4 5.3e-05 23.4 0.4 2.8 1 1 0 1 1 1 1 Pleckstrin homology domain zf_C2HC_14 PF18574.1 ELR14574.1 - 0.02 14.7 2.1 0.041 13.7 2.1 1.5 1 0 0 1 1 1 0 C2HC Zing finger domain Borealin PF10512.9 ELR14575.1 - 1.1 9.2 9.9 18 5.3 7.0 2.3 2 0 0 2 2 2 0 Cell division cycle-associated protein 8 Ank_2 PF12796.7 ELR14576.1 - 3.8e-80 264.6 5.6 5.2e-20 71.8 0.6 8.4 4 3 4 8 8 8 8 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ELR14576.1 - 1.5e-79 261.4 9.6 8.3e-12 45.4 0.1 11.2 5 2 5 11 11 11 11 Ankyrin repeats (many copies) Ank PF00023.30 ELR14576.1 - 9.7e-69 225.0 24.0 1.3e-08 34.9 0.5 12.8 12 0 0 12 12 12 11 Ankyrin repeat Ank_5 PF13857.6 ELR14576.1 - 8.4e-63 207.6 17.4 1.3e-10 41.3 0.1 10.8 5 3 6 11 11 11 11 Ankyrin repeats (many copies) Ank_3 PF13606.6 ELR14576.1 - 7.2e-60 191.9 8.9 7.8e-05 22.8 0.0 13.3 13 0 0 13 13 13 12 Ankyrin repeat Chorion_2 PF03964.15 ELR14576.1 - 2.4 9.1 9.9 0.1 13.5 1.4 2.5 2 0 0 2 2 2 0 Chorion family 2 RNA_capsid PF03035.14 ELR14577.1 - 0.074 13.1 0.2 0.087 12.8 0.2 1.1 1 0 0 1 1 1 0 Calicivirus putative RNA polymerase/capsid protein SET PF00856.28 ELR14578.1 - 2.6e-19 70.2 0.0 1.7e-18 67.6 0.0 2.1 1 1 0 1 1 1 1 SET domain Pre-SET PF05033.16 ELR14578.1 - 0.0034 18.0 0.6 0.0034 18.0 0.6 2.1 2 0 0 2 2 2 1 Pre-SET motif DUF4541 PF15074.6 ELR14578.1 - 0.039 14.5 0.0 0.12 13.0 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4541) DNA_primase_S PF01896.19 ELR14579.1 - 1.5e-51 174.9 0.3 2.3e-51 174.3 0.3 1.3 1 0 0 1 1 1 1 DNA primase small subunit THDPS_N_2 PF14805.6 ELR14579.1 - 0.13 12.5 0.0 0.45 10.8 0.0 1.9 2 0 0 2 2 2 0 Tetrahydrodipicolinate N-succinyltransferase N-terminal RRM_1 PF00076.22 ELR14581.1 - 5.9e-73 240.7 5.6 4.9e-18 64.7 0.1 6.4 6 0 0 6 6 6 6 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 ELR14581.1 - 3.5e-07 30.3 0.1 0.2 11.8 0.0 5.4 5 0 0 5 5 5 1 RNA recognition motif BUD22 PF09073.10 ELR14581.1 - 0.00045 19.7 30.9 0.00045 19.7 30.9 4.1 3 1 0 3 3 3 1 BUD22 Nup35_RRM_2 PF14605.6 ELR14581.1 - 0.00046 20.1 0.1 0.092 12.8 0.0 3.8 4 0 0 4 4 4 1 Nup53/35/40-type RNA recognition motif Limkain-b1 PF11608.8 ELR14581.1 - 0.00073 19.6 1.4 1.5 9.0 0.0 4.7 4 1 0 4 4 4 1 Limkain b1 RRM_Rrp7 PF17799.1 ELR14581.1 - 0.0095 15.8 0.2 0.9 9.3 0.0 3.8 3 2 1 4 4 4 1 Rrp7 RRM-like N-terminal domain OB_RNB PF08206.11 ELR14581.1 - 2.5 7.9 5.8 7 6.4 0.0 3.3 3 0 0 3 3 3 0 Ribonuclease B OB domain Pentapeptide PF00805.22 ELR14582.1 - 4.9e-26 90.0 15.0 7.8e-12 44.6 1.2 3.4 1 1 1 3 3 3 3 Pentapeptide repeats (8 copies) Pentapeptide_4 PF13599.6 ELR14582.1 - 3.5e-23 81.6 3.8 6.3e-10 39.1 0.0 2.4 1 1 2 3 3 3 3 Pentapeptide repeats (9 copies) BTB_2 PF02214.22 ELR14582.1 - 4e-15 55.9 0.0 8e-15 55.0 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain Pentapeptide_3 PF13576.6 ELR14582.1 - 4.5e-09 36.3 1.3 0.0034 17.5 0.0 3.5 2 1 1 3 3 3 2 Pentapeptide repeats (9 copies) DUF1449 PF07290.11 ELR14582.1 - 0.075 12.6 0.1 0.39 10.3 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1449) Ferlin_C PF16165.5 ELR14582.1 - 0.12 12.3 0.8 1.2 9.0 0.5 2.0 2 0 0 2 2 2 0 Ferlin C-terminus SOAR PF16533.5 ELR14582.1 - 1.4 8.9 8.6 2.5 8.1 0.6 2.3 2 0 0 2 2 2 0 STIM1 Orai1-activating region FTCD_C PF04961.12 ELR14582.1 - 2.4 7.9 4.4 1.5 8.6 1.4 2.0 2 1 1 3 3 3 0 Formiminotransferase-cyclodeaminase SPT6_acidic PF14632.6 ELR14582.1 - 3.8 8.2 9.8 16 6.2 1.0 2.3 2 0 0 2 2 2 0 Acidic N-terminal SPT6 DUF4710 PF15828.5 ELR14582.1 - 5.8 7.1 7.4 1.5 9.0 3.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4710) Kelch_4 PF13418.6 ELR14583.1 - 6.7e-31 106.0 7.0 4.9e-06 26.4 0.0 5.2 5 0 0 5 5 5 5 Galactose oxidase, central domain Kelch_5 PF13854.6 ELR14583.1 - 8.6e-31 105.4 0.2 2.6e-08 33.7 0.1 5.2 5 0 0 5 5 5 5 Kelch motif Kelch_6 PF13964.6 ELR14583.1 - 1.7e-26 91.6 1.1 0.0001 22.4 0.1 5.2 5 0 0 5 5 5 5 Kelch motif Kelch_3 PF13415.6 ELR14583.1 - 5.1e-23 80.8 11.3 3.8e-06 27.1 0.2 5.6 5 1 1 6 6 6 4 Galactose oxidase, central domain Kelch_1 PF01344.25 ELR14583.1 - 3.2e-20 71.4 0.0 6.8e-07 28.8 0.1 5.1 5 0 0 5 5 5 3 Kelch motif Kelch_2 PF07646.15 ELR14583.1 - 5e-13 48.4 0.1 2.6e-06 27.2 0.1 5.1 5 0 0 5 5 5 2 Kelch motif Spc7 PF08317.11 ELR14584.1 - 0.0004 19.4 22.0 0.0004 19.4 22.0 5.2 1 1 4 5 5 5 3 Spc7 kinetochore protein Filament PF00038.21 ELR14584.1 - 0.11 12.0 90.1 0.57 9.7 17.3 4.5 1 1 3 4 4 4 0 Intermediate filament protein Pox_A_type_inc PF04508.12 ELR14584.1 - 2.3 8.2 5.5 36 4.4 0.0 4.4 4 0 0 4 4 4 0 Viral A-type inclusion protein repeat ATG16 PF08614.11 ELR14584.1 - 3.2 7.9 121.4 0.38 10.9 16.2 5.3 1 1 3 4 4 4 0 Autophagy protein 16 (ATG16) TetR_C_31 PF17940.1 ELR14586.1 - 0.061 13.5 0.0 0.19 11.9 0.0 1.8 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain Phage_int_SAM_1 PF02899.17 ELR14586.1 - 0.098 13.0 0.1 1.4 9.3 0.1 2.8 2 0 0 2 2 2 0 Phage integrase, N-terminal SAM-like domain MCM PF00493.23 ELR14587.1 - 8.6e-94 312.8 0.0 1.7e-93 311.9 0.0 1.4 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 ELR14587.1 - 1.7e-26 92.5 0.0 3e-26 91.7 0.0 1.4 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 ELR14587.1 - 9.4e-23 80.5 1.1 2.3e-22 79.2 1.1 1.7 1 0 0 1 1 1 1 MCM AAA-lid domain Mg_chelatase PF01078.21 ELR14587.1 - 6.1e-09 35.6 0.2 1.9e-07 30.7 0.0 2.4 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 ELR14587.1 - 0.0012 18.9 0.0 0.0067 16.4 0.0 2.4 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) Sigma54_activat PF00158.26 ELR14587.1 - 0.0028 17.4 0.0 0.007 16.1 0.0 1.6 1 0 0 1 1 1 1 Sigma-54 interaction domain AAA_3 PF07726.11 ELR14587.1 - 0.0055 16.6 0.0 0.015 15.1 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA PF00004.29 ELR14587.1 - 0.081 13.3 1.8 2.3 8.7 0.0 2.6 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) DUF749 PF05370.11 ELR14587.1 - 0.21 11.7 1.8 0.34 11.0 0.3 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF749) Dynamin_N PF00350.23 ELR14590.1 - 8e-11 42.3 0.0 3.2e-10 40.3 0.0 1.9 1 1 0 1 1 1 1 Dynamin family MMR_HSR1 PF01926.23 ELR14590.1 - 2.2e-07 31.0 0.0 9.7e-07 28.9 0.0 2.0 1 1 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 ELR14590.1 - 0.0044 16.9 0.0 0.043 13.7 0.0 2.5 3 0 0 3 3 3 1 RsgA GTPase GTP_EFTU PF00009.27 ELR14590.1 - 0.014 14.9 0.0 0.18 11.3 0.0 2.3 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain SLAC1 PF03595.17 ELR14590.1 - 0.026 13.8 3.1 0.038 13.2 3.1 1.2 1 0 0 1 1 1 0 Voltage-dependent anion channel FeoB_N PF02421.18 ELR14590.1 - 0.2 11.2 0.0 5.7 6.5 0.0 2.3 2 0 0 2 2 2 0 Ferrous iron transport protein B Synaptobrevin PF00957.21 ELR14590.1 - 1.1 9.1 5.6 1.6 8.6 0.7 2.8 3 0 0 3 3 3 0 Synaptobrevin DEAD PF00270.29 ELR14592.1 - 1.5e-44 151.9 0.3 2.1e-44 151.4 0.3 1.2 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ELR14592.1 - 1.6e-21 76.7 3.5 1.7e-20 73.5 0.5 2.9 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 ELR14592.1 - 6.3e-06 26.3 0.1 1.5e-05 25.1 0.0 1.6 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit CMS1 PF14617.6 ELR14592.1 - 0.085 12.2 0.3 0.17 11.2 0.3 1.4 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit DUF1751 PF08551.10 ELR14593.1 - 7.6e-23 80.9 2.4 1.3e-22 80.2 2.4 1.4 1 0 0 1 1 1 1 Eukaryotic integral membrane protein (DUF1751) Rhomboid PF01694.22 ELR14593.1 - 4.9e-05 23.4 10.2 4.9e-05 23.4 10.2 1.9 2 0 0 2 2 2 1 Rhomboid family Snf7 PF03357.21 ELR14594.1 - 2.8e-45 154.0 2.1 3e-45 153.9 2.1 1.1 1 0 0 1 1 1 1 Snf7 DUF1319 PF07028.11 ELR14594.1 - 0.02 15.1 1.5 0.034 14.4 0.6 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF1319) Macoilin PF09726.9 ELR14594.1 - 0.043 12.4 5.6 0.056 12.0 5.6 1.0 1 0 0 1 1 1 0 Macoilin family FapA PF03961.13 ELR14594.1 - 0.061 11.9 3.5 0.091 11.4 3.5 1.3 1 0 0 1 1 1 0 Flagellar Assembly Protein A FAM153 PF15722.5 ELR14594.1 - 0.24 11.7 3.8 0.59 10.5 0.1 2.4 1 1 1 2 2 2 0 FAM153 family DUF1192 PF06698.11 ELR14594.1 - 0.26 11.4 0.1 0.26 11.4 0.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1192) Prefoldin PF02996.17 ELR14594.1 - 0.73 9.8 11.4 0.18 11.8 0.4 3.0 1 1 2 3 3 3 0 Prefoldin subunit Ribosomal_L7Ae PF01248.26 ELR14595.1 - 3.7e-23 81.1 0.2 8.6e-23 79.9 0.2 1.6 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family ORC3_N PF07034.11 ELR14596.1 - 0.39 9.8 1.8 0.62 9.1 1.8 1.2 1 0 0 1 1 1 0 Origin recognition complex (ORC) subunit 3 N-terminus V-ATPase_G_2 PF16999.5 ELR14596.1 - 0.51 10.8 5.8 1.8 9.0 5.8 1.9 1 0 0 1 1 1 0 Vacuolar (H+)-ATPase G subunit PKcGMP_CC PF16808.5 ELR14596.1 - 5.5 6.9 7.9 1.3 9.0 2.9 2.2 2 0 0 2 2 2 0 Coiled-coil N-terminus of cGMP-dependent protein kinase LAG1-DNAbind PF09271.11 ELR14597.1 - 0.052 14.2 1.8 0.51 11.0 0.8 2.5 2 1 0 2 2 2 0 LAG1, DNA binding PP_kinase_N PF13089.6 ELR14597.1 - 0.082 13.2 0.4 0.31 11.4 0.4 1.9 1 1 0 1 1 1 0 Polyphosphate kinase N-terminal domain BUD22 PF09073.10 ELR14597.1 - 7.4 5.8 7.8 7.3 5.8 0.3 2.2 2 0 0 2 2 2 0 BUD22 Lactamase_B PF00753.27 ELR14598.1 - 0.051 13.6 0.1 0.068 13.2 0.1 1.2 1 0 0 1 1 1 0 Metallo-beta-lactamase superfamily SulA PF03846.14 ELR14598.1 - 0.087 12.8 2.0 0.1 12.6 0.8 1.6 1 1 0 1 1 1 0 Cell division inhibitor SulA Pribosyl_synth PF14572.6 ELR14599.1 - 2e-32 112.7 1.0 6.1e-32 111.1 1.0 1.8 1 1 1 2 2 2 1 Phosphoribosyl synthetase-associated domain Pribosyltran_N PF13793.6 ELR14599.1 - 8.3e-30 103.1 4.7 5.8e-16 58.5 0.3 3.5 2 2 1 3 3 3 3 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyltran PF00156.27 ELR14599.1 - 2.3e-18 66.2 0.8 6e-18 64.9 0.8 1.7 2 0 0 2 2 2 1 Phosphoribosyl transferase domain Fucose_iso_N1 PF07881.12 ELR14599.1 - 0.04 13.8 0.1 5.9 6.7 0.0 2.4 1 1 1 2 2 2 0 L-fucose isomerase, first N-terminal domain Frag1 PF10277.9 ELR14600.1 - 5.1e-11 42.5 9.8 6.1e-11 42.3 9.8 1.1 1 0 0 1 1 1 1 Frag1/DRAM/Sfk1 family Phage_holin_3_6 PF07332.11 ELR14600.1 - 0.12 12.4 11.5 0.33 11.0 2.2 2.4 2 0 0 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III Pox_A14 PF05767.12 ELR14600.1 - 1.1 9.5 4.6 7.4 6.8 0.1 2.8 3 0 0 3 3 3 0 Poxvirus virion envelope protein A14 DUF2569 PF10754.9 ELR14600.1 - 1.2 9.6 7.8 0.97 9.9 4.9 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF2569) PIP5K PF01504.18 ELR14602.1 - 4.2e-86 288.6 0.2 4.2e-86 288.6 0.2 3.5 2 2 1 3 3 3 1 Phosphatidylinositol-4-phosphate 5-Kinase TMEM215 PF15746.5 ELR14602.1 - 0.09 12.2 5.2 0.3 10.5 5.2 1.8 1 0 0 1 1 1 0 TMEM215 family RL10P_insert PF17777.1 ELR14603.1 - 1.5e-22 79.4 0.1 2.7e-22 78.5 0.1 1.5 1 0 0 1 1 1 1 Insertion domain in 60S ribosomal protein L10P Ribosomal_L10 PF00466.20 ELR14603.1 - 3.8e-20 71.9 0.8 6.7e-20 71.1 0.4 1.6 2 0 0 2 2 2 1 Ribosomal protein L10 Ribosomal_60s PF00428.19 ELR14603.1 - 1.7e-15 57.4 9.0 1.7e-15 57.4 9.0 2.0 2 0 0 2 2 2 1 60s Acidic ribosomal protein NIF PF03031.18 ELR14604.1 - 3.5e-40 137.3 0.0 7.6e-40 136.2 0.0 1.5 1 1 0 1 1 1 1 NLI interacting factor-like phosphatase LRR_6 PF13516.6 ELR14605.1 - 9.6e-21 72.0 17.1 0.0057 16.6 0.2 13.6 16 0 0 16 16 16 6 Leucine Rich repeat LRR_4 PF12799.7 ELR14605.1 - 3.1e-14 52.9 0.3 0.16 12.4 0.0 8.8 7 2 4 11 11 11 4 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 ELR14605.1 - 1.5e-05 24.8 17.8 31 5.6 0.0 10.3 11 0 0 11 11 11 0 Leucine Rich Repeat SRI PF08236.11 ELR14605.1 - 0.022 14.9 1.0 0.05 13.8 1.0 1.5 1 0 0 1 1 1 0 SRI (Set2 Rpb1 interacting) domain Preseq_ALAS PF09029.10 ELR14605.1 - 5.5 7.5 13.2 24 5.5 0.2 4.7 4 0 0 4 4 4 0 5-aminolevulinate synthase presequence DUF3446 PF11928.8 ELR14605.1 - 6 7.3 11.2 15 6.0 11.2 1.7 1 0 0 1 1 1 0 Early growth response N-terminal domain RhoGEF PF00621.20 ELR14607.1 - 9.9e-34 117.2 0.0 3.1e-33 115.6 0.0 1.9 2 1 0 2 2 2 1 RhoGEF domain PH PF00169.29 ELR14607.1 - 0.02 15.4 0.0 0.047 14.2 0.0 1.6 1 0 0 1 1 1 0 PH domain Ribosomal_S15 PF00312.22 ELR14607.1 - 0.073 13.3 0.6 0.25 11.6 0.2 2.1 2 0 0 2 2 2 0 Ribosomal protein S15 LON_substr_bdg PF02190.16 ELR14607.1 - 0.28 11.0 2.0 0.73 9.7 0.0 2.4 2 1 0 2 2 2 0 ATP-dependent protease La (LON) substrate-binding domain FKBP26_C PF18046.1 ELR14607.1 - 0.3 11.2 1.4 1.3 9.1 0.1 2.7 3 0 0 3 3 3 0 FKBP26_C-terminal Nuc_deoxyrib_tr PF05014.15 ELR14608.1 - 2.8e-05 24.1 0.0 3.6e-05 23.8 0.0 1.2 1 0 0 1 1 1 1 Nucleoside 2-deoxyribosyltransferase Nuc_deoxyri_tr3 PF11071.8 ELR14608.1 - 0.0075 16.3 0.0 0.0099 15.9 0.0 1.1 1 0 0 1 1 1 1 Nucleoside 2-deoxyribosyltransferase YtoQ Nuc_deoxyri_tr2 PF15891.5 ELR14608.1 - 0.15 12.4 0.0 0.29 11.5 0.0 1.4 1 0 0 1 1 1 0 Nucleoside 2-deoxyribosyltransferase like LRR_8 PF13855.6 ELR14609.1 - 2.1e-27 94.6 40.7 1.3e-12 47.2 1.1 4.9 2 2 3 5 5 5 5 Leucine rich repeat VPS9 PF02204.18 ELR14609.1 - 1.4e-24 86.3 0.0 2.7e-24 85.4 0.0 1.5 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain LRR_4 PF12799.7 ELR14609.1 - 5.1e-22 77.6 16.8 2e-05 24.8 0.7 5.7 2 2 3 6 6 6 6 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 ELR14609.1 - 7.3e-06 25.8 13.0 27 5.9 0.0 8.0 7 0 0 7 7 7 0 Leucine Rich Repeat LRR_9 PF14580.6 ELR14609.1 - 0.0007 19.1 3.5 0.094 12.2 0.0 3.1 1 1 2 3 3 3 1 Leucine-rich repeat LRR_6 PF13516.6 ELR14609.1 - 0.0036 17.2 18.9 4 7.7 0.1 7.2 8 0 0 8 8 7 2 Leucine Rich repeat CUE PF02845.16 ELR14609.1 - 0.0045 16.7 0.0 0.01 15.5 0.0 1.7 1 0 0 1 1 1 1 CUE domain DUF5601 PF18151.1 ELR14609.1 - 0.0066 16.7 0.0 0.027 14.8 0.0 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF5601) SDA1 PF05285.12 ELR14609.1 - 0.1 12.0 9.1 0.15 11.4 9.1 1.2 1 0 0 1 1 1 0 SDA1 Nop14 PF04147.12 ELR14609.1 - 4.4 5.4 18.1 6.7 4.8 18.1 1.2 1 0 0 1 1 1 0 Nop14-like family Pox_Ag35 PF03286.14 ELR14609.1 - 8.1 6.2 10.5 20 4.9 10.5 1.6 1 0 0 1 1 1 0 Pox virus Ag35 surface protein Pkinase PF00069.25 ELR14612.1 - 3.9e-60 203.5 0.0 1.6e-59 201.4 0.0 1.8 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR14612.1 - 7.7e-29 100.8 0.0 1.1e-28 100.2 0.0 1.3 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ELR14612.1 - 7.2e-05 22.2 0.4 0.053 12.8 0.1 2.4 2 1 0 2 2 2 2 Kinase-like RIO1 PF01163.22 ELR14612.1 - 0.0091 15.6 0.1 0.014 15.0 0.1 1.2 1 0 0 1 1 1 1 RIO1 family Kdo PF06293.14 ELR14612.1 - 0.15 11.4 0.1 0.23 10.8 0.1 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family LRR_4 PF12799.7 ELR14613.1 - 1.4e-38 130.3 53.7 2e-08 34.4 3.7 7.1 3 2 5 8 8 8 8 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 ELR14613.1 - 5.3e-23 80.5 38.0 3e-05 23.7 4.4 5.8 2 2 0 5 5 5 5 Leucine rich repeat LRR_9 PF14580.6 ELR14613.1 - 6.5e-22 77.9 14.6 1.6e-10 40.8 0.2 4.1 1 1 3 4 4 4 4 Leucine-rich repeat LRR_6 PF13516.6 ELR14613.1 - 3.9e-08 32.7 30.7 1.4 9.1 0.2 9.5 11 0 0 11 11 11 6 Leucine Rich repeat LRR_1 PF00560.33 ELR14613.1 - 3.7e-05 23.7 32.7 4.5 8.2 0.2 10.4 9 2 1 10 10 10 3 Leucine Rich Repeat LRR_2 PF07723.13 ELR14613.1 - 0.24 12.1 2.8 10 7.0 0.0 4.5 4 2 1 5 5 5 0 Leucine Rich Repeat Dicty_CAR PF05462.11 ELR14614.1 - 3e-08 33.1 10.6 4.2e-08 32.7 10.6 1.2 1 0 0 1 1 1 1 Slime mold cyclic AMP receptor 7tm_2 PF00002.24 ELR14614.1 - 0.00026 20.3 12.1 0.00037 19.9 12.1 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) COX6C PF02937.15 ELR14614.1 - 1.4 9.1 3.2 38 4.5 0.2 2.7 2 0 0 2 2 2 0 Cytochrome c oxidase subunit VIc Cation_efflux PF01545.21 ELR14615.1 - 1.4e-44 152.2 5.2 1.7e-44 152.0 5.2 1.1 1 0 0 1 1 1 1 Cation efflux family HNOB PF07700.15 ELR14616.1 - 4.4e-29 101.5 0.0 9e-20 71.3 0.0 2.6 2 0 0 2 2 2 2 Haem-NO-binding HNOBA PF07701.14 ELR14616.1 - 9e-17 61.2 0.9 9.4e-08 31.7 0.0 3.8 2 1 1 3 3 3 3 Heme NO binding associated RasGAP PF00616.19 ELR14616.1 - 8e-11 42.0 0.0 8.8e-07 28.8 0.0 2.6 2 1 1 3 3 3 2 GTPase-activator protein for Ras-like GTPase PACT_coil_coil PF10495.9 ELR14616.1 - 0.14 12.7 0.4 7.6 7.2 0.1 2.7 2 0 0 2 2 2 0 Pericentrin-AKAP-450 domain of centrosomal targeting protein DUF3306 PF11748.8 ELR14616.1 - 3.5 8.5 0.0 3.5 8.5 0.0 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF3306) SNARE PF05739.19 ELR14617.1 - 2.6e-07 30.5 0.4 3.8e-07 30.0 0.4 1.2 1 0 0 1 1 1 1 SNARE domain DUF1664 PF07889.12 ELR14617.1 - 0.33 11.0 4.0 0.43 10.6 4.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) SAM_2 PF07647.17 ELR14618.1 - 2.4e-45 152.5 0.6 1.6e-15 57.0 0.1 3.4 3 0 0 3 3 3 3 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 ELR14618.1 - 3.4e-42 142.7 3.2 9.6e-16 58.0 0.2 3.3 3 0 0 3 3 3 3 SAM domain (Sterile alpha motif) RasGAP PF00616.19 ELR14618.1 - 4e-16 59.3 0.0 1.1e-15 57.9 0.0 1.7 1 1 0 1 1 1 1 GTPase-activator protein for Ras-like GTPase SAM_PNT PF02198.16 ELR14618.1 - 4.2e-07 29.8 0.1 0.04 13.9 0.0 3.1 2 1 1 3 3 3 2 Sterile alpha motif (SAM)/Pointed domain SAM_3 PF18016.1 ELR14618.1 - 5.6e-06 26.1 0.3 0.016 15.0 0.0 3.4 3 0 0 3 3 3 1 SAM domain (Sterile alpha motif) DUF4164 PF13747.6 ELR14618.1 - 0.038 14.3 3.6 0.73 10.1 4.4 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4164) Pox_A31 PF05771.11 ELR14618.1 - 0.11 12.5 0.0 12 6.0 0.0 2.3 2 0 0 2 2 2 0 Poxvirus A31 protein Zip PF02535.22 ELR14619.1 - 2.2e-23 83.0 18.6 9.4e-21 74.4 18.6 2.3 1 1 0 1 1 1 1 ZIP Zinc transporter Pkinase PF00069.25 ELR14620.1 - 5.6e-58 196.4 0.1 3.6e-57 193.7 0.1 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR14620.1 - 1.6e-26 93.2 0.9 2e-18 66.6 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 ELR14620.1 - 4.5e-05 22.9 3.4 0.007 15.7 0.0 2.8 3 0 0 3 3 3 2 Kinase-like APH PF01636.23 ELR14620.1 - 0.00045 20.2 1.3 0.08 12.8 0.4 2.5 2 1 1 3 3 3 2 Phosphotransferase enzyme family Kdo PF06293.14 ELR14620.1 - 0.0015 17.9 0.1 0.0015 17.9 0.1 1.9 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 ELR14620.1 - 0.0036 16.3 0.7 0.0056 15.7 0.1 1.5 1 1 0 2 2 2 1 Haspin like kinase domain Seadorna_VP7 PF07387.11 ELR14620.1 - 0.039 13.0 0.0 0.063 12.3 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 SNF2_N PF00176.23 ELR14620.1 - 0.052 12.3 0.4 0.076 11.7 0.4 1.2 1 0 0 1 1 1 0 SNF2 family N-terminal domain RIO1 PF01163.22 ELR14620.1 - 9 5.8 8.6 0.49 10.0 0.1 2.7 2 1 1 3 3 3 0 RIO1 family Ank_4 PF13637.6 ELR14621.1 - 1.1e-12 48.2 0.6 4e-06 27.3 0.1 1.6 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 ELR14621.1 - 6.9e-10 39.4 0.0 8.4e-10 39.1 0.0 1.1 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 ELR14621.1 - 4.4e-09 36.4 0.3 1.1e-08 35.1 0.1 1.7 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 ELR14621.1 - 6.8e-08 32.2 0.4 1.6e-07 31.1 0.1 1.7 2 0 0 2 2 2 1 Ankyrin repeat Ank PF00023.30 ELR14621.1 - 3.6e-07 30.3 0.8 8.3e-07 29.2 0.8 1.6 1 0 0 1 1 1 1 Ankyrin repeat HALZ PF02183.18 ELR14622.1 - 1.2e-08 35.0 0.4 6.3e-05 23.1 0.0 2.4 1 1 1 2 2 2 2 Homeobox associated leucine zipper KASH_CCD PF14662.6 ELR14622.1 - 2e-06 27.8 4.0 0.00045 20.1 0.5 1.9 1 1 1 2 2 2 2 Coiled-coil region of CCDC155 or KASH ADIP PF11559.8 ELR14622.1 - 1.4e-05 25.2 1.2 2.4e-05 24.4 1.2 1.3 1 0 0 1 1 1 1 Afadin- and alpha -actinin-Binding bZIP_1 PF00170.21 ELR14622.1 - 2.2e-05 24.4 0.3 0.041 14.0 0.0 2.6 1 1 1 2 2 2 2 bZIP transcription factor ZapB PF06005.12 ELR14622.1 - 0.00012 22.5 0.1 0.002 18.5 0.0 2.1 1 1 1 2 2 2 2 Cell division protein ZapB DivIC PF04977.15 ELR14622.1 - 0.0018 18.0 3.3 0.51 10.2 0.3 2.5 1 1 1 2 2 2 2 Septum formation initiator bZIP_2 PF07716.15 ELR14622.1 - 0.0028 17.7 0.0 1.6 8.9 0.0 2.3 1 1 0 2 2 2 1 Basic region leucine zipper Shugoshin_N PF07558.11 ELR14622.1 - 0.0045 16.8 0.1 0.013 15.3 0.1 1.8 1 1 1 2 2 2 1 Shugoshin N-terminal coiled-coil region DUF3450 PF11932.8 ELR14622.1 - 0.0052 16.1 1.8 0.0069 15.7 1.8 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3450) CENP-F_leu_zip PF10473.9 ELR14622.1 - 0.0054 16.8 0.4 0.0073 16.3 0.4 1.2 1 0 0 1 1 1 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Atg14 PF10186.9 ELR14622.1 - 0.012 14.7 0.6 0.017 14.3 0.6 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Cnn_1N PF07989.11 ELR14622.1 - 0.014 15.5 0.3 0.038 14.1 0.3 1.7 1 1 0 1 1 1 0 Centrosomin N-terminal motif 1 DUF2205 PF10224.9 ELR14622.1 - 0.015 15.3 0.2 1.3 9.1 0.1 2.3 1 1 1 2 2 2 0 Short coiled-coil protein YabA PF06156.13 ELR14622.1 - 0.017 15.7 0.5 0.035 14.7 0.5 1.5 1 0 0 1 1 1 0 Initiation control protein YabA JIP_LZII PF16471.5 ELR14622.1 - 0.02 15.1 1.1 0.57 10.4 0.8 2.2 1 1 1 2 2 2 0 JNK-interacting protein leucine zipper II DUF1664 PF07889.12 ELR14622.1 - 0.026 14.6 1.0 0.049 13.7 1.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) ATG16 PF08614.11 ELR14622.1 - 0.034 14.4 4.1 0.046 13.9 4.1 1.1 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) Csm1_N PF18504.1 ELR14622.1 - 0.044 14.1 0.9 4 7.9 0.1 2.2 1 1 1 2 2 2 0 Csm1 N-terminal domain Ax_dynein_light PF10211.9 ELR14622.1 - 0.052 13.5 0.2 0.073 13.0 0.2 1.2 1 0 0 1 1 1 0 Axonemal dynein light chain TSC22 PF01166.18 ELR14622.1 - 0.053 13.8 0.1 5.8 7.3 0.0 2.9 1 1 2 3 3 3 0 TSC-22/dip/bun family CCDC144C PF14915.6 ELR14622.1 - 0.075 12.1 1.5 0.094 11.8 1.5 1.1 1 0 0 1 1 1 0 CCDC144C protein coiled-coil region Spc7 PF08317.11 ELR14622.1 - 0.075 11.9 1.8 0.1 11.5 1.8 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein PRKG1_interact PF15898.5 ELR14622.1 - 0.078 13.9 1.5 10 7.1 0.1 2.7 1 1 2 3 3 3 0 cGMP-dependent protein kinase interacting domain DUF2218 PF09981.9 ELR14622.1 - 0.084 13.3 1.7 2.8 8.4 0.1 2.4 1 1 1 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2218) DUF2046 PF09755.9 ELR14622.1 - 0.084 12.1 0.1 0.19 10.9 0.1 1.5 1 1 0 1 1 1 0 Uncharacterized conserved protein H4 (DUF2046) Rootletin PF15035.6 ELR14622.1 - 0.097 12.7 2.7 0.46 10.5 0.2 1.9 1 1 1 2 2 2 0 Ciliary rootlet component, centrosome cohesion Leu_zip PF15294.6 ELR14622.1 - 0.11 12.0 2.1 0.17 11.3 2.1 1.3 1 0 0 1 1 1 0 Leucine zipper Syntaxin-6_N PF09177.11 ELR14622.1 - 0.13 12.9 1.3 0.25 11.9 1.2 1.5 1 1 0 1 1 1 0 Syntaxin 6, N-terminal IES5 PF17335.2 ELR14622.1 - 0.13 12.6 0.6 0.44 10.8 0.1 1.9 1 1 1 2 2 2 0 Ino80 complex subunit 5 Lectin_N PF03954.14 ELR14622.1 - 0.15 11.8 0.6 7.5 6.3 0.2 2.3 1 1 1 2 2 2 0 Hepatic lectin, N-terminal domain Bac_rhamnosid_C PF17390.2 ELR14623.1 - 2.3e-13 49.7 0.0 3.4e-13 49.2 0.0 1.3 1 0 0 1 1 1 1 Bacterial alpha-L-rhamnosidase C-terminal domain zf-UBR PF02207.20 ELR14626.1 - 4.8e-05 23.5 0.4 7.3e-05 22.9 0.4 1.4 1 1 0 1 1 1 1 Putative zinc finger in N-recognin (UBR box) zf-B_box PF00643.24 ELR14626.1 - 0.03 14.5 0.0 0.063 13.4 0.0 1.5 1 0 0 1 1 1 0 B-box zinc finger MarR PF01047.22 ELR14626.1 - 0.15 12.0 0.0 0.27 11.2 0.0 1.4 1 0 0 1 1 1 0 MarR family zf-RING_5 PF14634.6 ELR14627.1 - 0.039 13.9 0.3 0.039 13.9 0.3 2.7 3 0 0 3 3 3 0 zinc-RING finger domain Ras PF00071.22 ELR14628.1 - 1e-50 171.5 0.0 1.2e-50 171.3 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR14628.1 - 3.1e-22 79.0 0.0 4.1e-22 78.6 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR14628.1 - 4.9e-06 26.1 0.0 5.5e-06 25.9 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Myotub-related PF06602.14 ELR14629.1 - 1.8e-113 379.0 0.0 2.8e-113 378.4 0.0 1.2 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain Fascin PF06268.13 ELR14629.1 - 3e-08 33.9 0.1 0.0032 17.7 0.0 4.1 3 1 1 4 4 4 2 Fascin domain FRG1 PF06229.12 ELR14629.1 - 9.8e-05 22.1 0.0 0.064 13.0 0.0 2.6 2 0 0 2 2 2 2 FRG1-like domain Y_phosphatase3 PF13350.6 ELR14629.1 - 0.07 13.1 0.0 0.16 11.9 0.0 1.6 1 0 0 1 1 1 0 Tyrosine phosphatase family GRAM PF02893.20 ELR14629.1 - 0.091 12.6 0.0 0.42 10.5 0.0 2.0 2 0 0 2 2 2 0 GRAM domain DSPc PF00782.20 ELR14629.1 - 0.13 12.1 0.0 0.24 11.2 0.0 1.3 1 0 0 1 1 1 0 Dual specificity phosphatase, catalytic domain Acetyltransf_17 PF17668.1 ELR14629.1 - 0.21 12.4 0.8 0.69 10.7 0.1 2.2 3 0 0 3 3 3 0 Acetyltransferase (GNAT) domain B56 PF01603.20 ELR14629.1 - 0.27 10.2 0.0 0.4 9.6 0.0 1.1 1 0 0 1 1 1 0 Protein phosphatase 2A regulatory B subunit (B56 family) Hydrolase_4 PF12146.8 ELR14630.1 - 1.4e-08 34.3 0.1 1.4e-06 27.8 0.0 2.5 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 ELR14630.1 - 3.6e-05 23.5 0.9 0.00063 19.5 0.1 2.5 3 0 0 3 3 3 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 ELR14630.1 - 0.00022 21.9 0.0 0.0054 17.4 0.0 2.2 2 0 0 2 2 2 1 Alpha/beta hydrolase family Esterase PF00756.20 ELR14630.1 - 0.0012 18.5 0.0 1.5 8.4 0.0 2.5 2 0 0 2 2 2 2 Putative esterase Peptidase_S15 PF02129.18 ELR14630.1 - 0.0045 16.6 0.1 0.0045 16.6 0.1 2.2 2 0 0 2 2 2 1 X-Pro dipeptidyl-peptidase (S15 family) Peptidase_S9 PF00326.21 ELR14630.1 - 0.29 10.6 1.5 0.5 9.8 0.1 2.1 3 0 0 3 3 3 0 Prolyl oligopeptidase family Peptidase_S49_N PF08496.10 ELR14630.1 - 1.9 8.5 10.0 1.6 8.8 0.3 2.5 2 0 0 2 2 2 0 Peptidase family S49 N-terminal BRF1 PF07741.13 ELR14630.1 - 2.3 8.6 13.8 4.6 7.7 7.6 2.5 2 0 0 2 2 2 0 Brf1-like TBP-binding domain RNase_T PF00929.24 ELR14631.1 - 2.1e-14 54.4 0.0 6.9e-14 52.7 0.0 1.9 2 0 0 2 2 2 1 Exonuclease DUF3322 PF11795.8 ELR14631.1 - 0.044 13.8 0.0 0.16 12.0 0.0 2.0 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria N-term (DUF3322) AAA_18 PF13238.6 ELR14631.1 - 1.1 9.8 3.6 27 5.3 3.4 2.5 1 1 1 2 2 2 0 AAA domain Ank_2 PF12796.7 ELR14632.1 - 8.1e-10 39.2 0.0 1.5e-09 38.3 0.0 1.4 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ELR14632.1 - 3e-09 37.2 0.0 5.9e-08 33.1 0.0 2.0 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 ELR14632.1 - 2.1e-08 34.3 0.1 2.1e-05 24.7 0.0 2.2 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 ELR14632.1 - 6.5e-08 32.2 0.0 0.00046 20.4 0.0 3.0 2 1 1 3 3 3 2 Ankyrin repeat Ank PF00023.30 ELR14632.1 - 1.8e-06 28.1 0.0 0.0051 17.2 0.0 2.5 2 0 0 2 2 2 2 Ankyrin repeat zf-MYND PF01753.18 ELR14632.1 - 4.1e-06 26.8 14.6 6.7e-06 26.1 14.6 1.4 1 0 0 1 1 1 1 MYND finger zf-HIT PF04438.16 ELR14632.1 - 0.0014 18.4 10.1 0.002 18.0 10.1 1.2 1 0 0 1 1 1 1 HIT zinc finger PhyH PF05721.13 ELR14633.1 - 2.4e-08 34.5 0.0 7.7e-08 32.8 0.0 1.9 1 1 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) F-box-like PF12937.7 ELR14634.1 - 2e-08 34.0 0.9 9.4e-08 31.8 0.9 2.2 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ELR14634.1 - 2.8e-05 23.9 2.1 3e-05 23.8 0.5 1.9 2 0 0 2 2 2 1 F-box domain ABATE PF07336.11 ELR14634.1 - 0.025 15.3 1.1 0.069 13.8 1.1 1.7 1 0 0 1 1 1 0 Putative stress-induced transcription regulator Actin PF00022.19 ELR14635.1 - 4.6e-154 512.9 0.0 1.5e-153 511.3 0.0 1.6 1 1 0 1 1 1 1 Actin Methyltransf_4 PF02390.17 ELR14636.1 - 1.1e-22 80.3 0.0 2.9e-22 78.9 0.0 1.7 1 1 0 1 1 1 1 Putative methyltransferase Methyltransf_31 PF13847.6 ELR14636.1 - 0.00058 19.7 0.0 0.00099 18.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_32 PF13679.6 ELR14636.1 - 0.0091 16.0 0.0 0.014 15.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ELR14636.1 - 0.012 16.3 0.0 0.024 15.4 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_12 PF08242.12 ELR14636.1 - 0.019 15.7 0.0 0.041 14.6 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_11 PF08241.12 ELR14636.1 - 0.094 13.4 0.0 0.17 12.6 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain MTS PF05175.14 ELR14636.1 - 0.11 12.1 0.0 0.21 11.1 0.0 1.6 1 1 0 1 1 1 0 Methyltransferase small domain MetW PF07021.12 ELR14636.1 - 0.11 12.1 0.0 0.18 11.4 0.0 1.3 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW AdoMet_MTase PF07757.13 ELR14636.1 - 0.13 12.6 0.0 0.23 11.8 0.0 1.3 1 0 0 1 1 1 0 Predicted AdoMet-dependent methyltransferase TFIID-18kDa PF02269.16 ELR14637.1 - 1.4e-17 63.4 2.5 5e-15 55.3 0.2 2.2 1 1 1 2 2 2 2 Transcription initiation factor IID, 18kD subunit ArAE_2_N PF10337.9 ELR14637.1 - 0.13 11.3 0.3 0.16 11.0 0.3 1.0 1 0 0 1 1 1 0 Putative ER transporter, 6TM, N-terminal CENP-O PF09496.10 ELR14638.1 - 3e-13 50.3 0.7 5.3e-13 49.4 0.7 1.4 1 1 0 1 1 1 1 Cenp-O kinetochore centromere component FCSD-flav_bind PF09242.11 ELR14638.1 - 0.11 12.8 0.0 0.2 12.1 0.0 1.4 1 0 0 1 1 1 0 Flavocytochrome c sulphide dehydrogenase, flavin-binding Myotub-related PF06602.14 ELR14640.1 - 6e-139 462.9 0.0 9.2e-139 462.3 0.0 1.3 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain Y_phosphatase PF00102.27 ELR14640.1 - 0.0024 17.5 0.0 0.0042 16.7 0.0 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.6 ELR14640.1 - 0.004 17.1 0.0 0.0078 16.2 0.0 1.4 1 0 0 1 1 1 1 Tyrosine phosphatase family DSPc PF00782.20 ELR14640.1 - 0.034 14.0 0.0 0.12 12.2 0.0 1.9 1 0 0 1 1 1 0 Dual specificity phosphatase, catalytic domain 3-PAP PF12578.8 ELR14640.1 - 0.07 12.9 1.9 0.11 12.3 0.3 2.2 2 0 0 2 2 2 0 Myotubularin-associated protein PKcGMP_CC PF16808.5 ELR14640.1 - 0.21 11.5 0.5 0.57 10.1 0.5 1.8 1 0 0 1 1 1 0 Coiled-coil N-terminus of cGMP-dependent protein kinase Ras PF00071.22 ELR14642.1 - 2.9e-41 140.8 0.0 3.4e-41 140.6 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR14642.1 - 2.9e-22 79.1 0.0 4e-22 78.7 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR14642.1 - 0.00013 21.5 0.0 0.00015 21.3 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family SNF2_N PF00176.23 ELR14643.1 - 8.5e-46 156.3 0.3 4e-43 147.5 0.0 2.7 2 0 0 2 2 2 2 SNF2 family N-terminal domain Helicase_C PF00271.31 ELR14643.1 - 1.8e-19 70.1 0.1 3e-17 63.0 0.0 3.1 3 0 0 3 3 3 1 Helicase conserved C-terminal domain F-box-like PF12937.7 ELR14643.1 - 2.3e-09 37.0 0.3 2.3e-09 37.0 0.3 1.8 2 0 0 2 2 2 1 F-box-like ResIII PF04851.15 ELR14643.1 - 4.8e-08 33.2 0.2 2.1e-07 31.1 0.0 2.2 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit F-box PF00646.33 ELR14643.1 - 0.0033 17.3 0.4 0.01 15.7 0.4 1.9 1 0 0 1 1 1 1 F-box domain HDA2-3 PF11496.8 ELR14643.1 - 0.0044 16.2 1.8 0.018 14.2 0.0 2.7 2 1 0 2 2 2 1 Class II histone deacetylase complex subunits 2 and 3 AAA_34 PF13872.6 ELR14643.1 - 0.01 14.7 0.1 0.034 13.0 0.1 1.8 1 1 0 1 1 1 0 P-loop containing NTP hydrolase pore-1 DUF1768 PF08719.11 ELR14645.1 - 1.5e-12 48.1 0.0 2.1e-12 47.6 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF1768) PGI PF00342.19 ELR14646.1 - 1.8e-240 798.6 0.2 2.1e-240 798.4 0.2 1.0 1 0 0 1 1 1 1 Phosphoglucose isomerase RFX_DNA_binding PF02257.15 ELR14648.1 - 1.6e-07 31.8 0.1 6.8e-07 29.8 0.1 2.0 1 1 0 1 1 1 1 RFX DNA-binding domain DUF1772 PF08592.11 ELR14648.1 - 9 6.6 10.5 0.69 10.2 4.0 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF1772) COR PF16095.5 ELR14650.1 - 2.1e-26 92.9 0.0 3.8e-26 92.1 0.0 1.3 1 0 0 1 1 1 1 C-terminal of Roc, COR, domain Roc PF08477.13 ELR14650.1 - 6.5e-20 71.5 0.1 6.7e-15 55.4 0.0 2.5 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 ELR14650.1 - 7.2e-09 35.4 0.1 6e-06 26.0 0.0 2.3 2 0 0 2 2 2 2 Ras family LRR_8 PF13855.6 ELR14650.1 - 1.8e-08 34.0 2.1 5.8e-08 32.4 1.8 2.1 2 1 0 2 2 2 1 Leucine rich repeat LRR_4 PF12799.7 ELR14650.1 - 4.6e-07 30.1 0.5 0.001 19.4 0.1 2.5 2 0 0 2 2 2 2 Leucine Rich repeats (2 copies) Arf PF00025.21 ELR14650.1 - 4.3e-06 26.3 0.0 0.02 14.4 0.0 2.4 2 0 0 2 2 2 2 ADP-ribosylation factor family AAA_15 PF13175.6 ELR14650.1 - 5.1e-05 23.1 0.0 8.3e-05 22.5 0.0 1.2 1 0 0 1 1 1 1 AAA ATPase domain MMR_HSR1 PF01926.23 ELR14650.1 - 0.015 15.4 0.0 0.047 13.8 0.0 1.8 1 0 0 1 1 1 0 50S ribosome-binding GTPase PduV-EutP PF10662.9 ELR14650.1 - 0.036 13.8 0.0 0.37 10.5 0.0 2.2 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Gtr1_RagA PF04670.12 ELR14650.1 - 0.11 11.9 0.3 6.1 6.1 0.0 2.3 2 0 0 2 2 2 0 Gtr1/RagA G protein conserved region AAA_23 PF13476.6 ELR14650.1 - 0.14 12.7 0.1 0.24 11.9 0.1 1.4 1 0 0 1 1 1 0 AAA domain LRR_1 PF00560.33 ELR14650.1 - 0.14 12.8 0.7 1.1e+02 3.9 0.0 3.7 3 0 0 3 3 3 0 Leucine Rich Repeat Toprim_4 PF13662.6 ELR14650.1 - 0.16 12.4 0.1 18 5.9 0.0 2.8 2 1 0 2 2 2 0 Toprim domain Pkinase_Tyr PF07714.17 ELR14651.1 - 5.7e-48 163.4 0.0 8.8e-48 162.8 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ELR14651.1 - 1.3e-41 142.7 0.0 3.2e-27 95.5 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain COR PF16095.5 ELR14651.1 - 0.038 13.8 0.1 0.08 12.7 0.1 1.5 1 0 0 1 1 1 0 C-terminal of Roc, COR, domain SH3_9 PF14604.6 ELR14651.1 - 0.053 13.4 0.0 0.12 12.3 0.0 1.6 1 0 0 1 1 1 0 Variant SH3 domain SR-25 PF10500.9 ELR14651.1 - 0.37 10.4 4.4 0.61 9.7 4.4 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein ABC_tran PF00005.27 ELR14652.1 - 5e-24 85.4 0.0 8.4e-24 84.6 0.0 1.3 1 0 0 1 1 1 1 ABC transporter ABC2_membrane PF01061.24 ELR14652.1 - 7.1e-14 51.7 17.4 7.1e-14 51.7 17.4 2.0 3 0 0 3 3 3 1 ABC-2 type transporter AAA_21 PF13304.6 ELR14652.1 - 4e-06 26.9 0.4 0.0029 17.5 0.1 2.3 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system ABC2_membrane_3 PF12698.7 ELR14652.1 - 0.00038 19.7 9.7 0.00038 19.7 9.7 1.9 2 0 0 2 2 2 1 ABC-2 family transporter protein SMC_N PF02463.19 ELR14652.1 - 0.0033 16.9 0.2 0.07 12.6 0.0 2.1 2 0 0 2 2 2 1 RecF/RecN/SMC N terminal domain AAA PF00004.29 ELR14652.1 - 0.031 14.7 0.0 0.13 12.7 0.0 2.0 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 ELR14652.1 - 0.047 14.1 0.0 0.088 13.2 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain SbcCD_C PF13558.6 ELR14652.1 - 0.089 13.0 0.1 0.57 10.5 0.1 2.3 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit RsgA_GTPase PF03193.16 ELR14652.1 - 0.12 12.3 0.0 0.26 11.2 0.0 1.5 1 0 0 1 1 1 0 RsgA GTPase ATP_bind_1 PF03029.17 ELR14652.1 - 0.22 11.3 0.2 0.38 10.5 0.2 1.4 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein AAA_24 PF13479.6 ELR14652.1 - 0.54 10.0 1.6 0.54 9.9 0.0 1.7 2 0 0 2 2 2 0 AAA domain YliH PF10799.8 ELR14653.1 - 0.15 12.0 0.1 0.19 11.6 0.1 1.2 1 0 0 1 1 1 0 Biofilm formation protein (YliH/bssR) OrfB_Zn_ribbon PF07282.11 ELR14654.1 - 1e-14 54.2 2.1 1.3e-14 53.9 2.1 1.1 1 0 0 1 1 1 1 Putative transposase DNA-binding domain Ge1_WD40 PF16529.5 ELR14654.1 - 0.0036 16.3 0.1 0.0037 16.3 0.1 1.1 1 0 0 1 1 1 1 WD40 region of Ge1, enhancer of mRNA-decapping protein DUF5348 PF17295.2 ELR14654.1 - 0.047 13.6 0.1 0.074 13.0 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF5348) Tnp_zf-ribbon_2 PF13842.6 ELR14654.1 - 0.25 12.2 3.9 8.4 7.3 1.1 2.5 2 0 0 2 2 2 0 DDE_Tnp_1-like zinc-ribbon DUF4326 PF14216.6 ELR14655.1 - 0.094 13.4 0.0 0.18 12.6 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4326) G-alpha PF00503.20 ELR14657.1 - 1.7e-37 129.4 0.2 1.8e-37 129.3 0.2 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 ELR14657.1 - 4.8e-07 29.4 0.0 6.2e-07 29.0 0.0 1.3 1 1 0 1 1 1 1 ADP-ribosylation factor family rve PF00665.26 ELR14658.1 - 0.00032 20.9 0.4 0.57 10.4 0.0 2.4 1 1 1 2 2 2 2 Integrase core domain DUF2456 PF10445.9 ELR14658.1 - 0.033 14.3 0.2 0.068 13.3 0.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2456) DUF4734 PF15881.5 ELR14658.1 - 0.051 13.7 1.4 0.16 12.2 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4734) RVT_2 PF07727.14 ELR14659.1 - 2.6e-05 24.0 0.4 5.9e-05 22.8 0.0 1.7 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) Rhamno_transf PF11316.8 ELR14660.1 - 0.076 12.4 0.0 0.2 11.0 0.0 1.7 1 0 0 1 1 1 0 Putative rhamnosyl transferase SH3_2 PF07653.17 ELR14661.1 - 3.6e-05 23.3 0.2 0.0001 21.9 0.0 1.9 2 0 0 2 2 2 1 Variant SH3 domain SH3_9 PF14604.6 ELR14661.1 - 4e-05 23.4 0.0 8.1e-05 22.4 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 ELR14661.1 - 0.0002 20.9 0.0 0.00046 19.7 0.0 1.6 1 0 0 1 1 1 1 SH3 domain Cupin_2 PF07883.11 ELR14662.1 - 0.00011 21.8 0.5 0.00011 21.8 0.5 1.9 2 0 0 2 2 2 1 Cupin domain DUF1348 PF07080.11 ELR14664.1 - 6.9e-62 207.1 4.8 9.5e-62 206.7 4.8 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1348) SnoaL_2 PF12680.7 ELR14664.1 - 6.4e-10 39.6 1.8 6.4e-10 39.6 1.8 2.1 2 0 0 2 2 2 1 SnoaL-like domain DUF4440 PF14534.6 ELR14664.1 - 0.00024 21.4 0.4 0.00065 20.1 0.4 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4440) SnoaL PF07366.12 ELR14664.1 - 0.0003 20.6 0.2 0.00059 19.6 0.2 1.5 1 0 0 1 1 1 1 SnoaL-like polyketide cyclase F-box-like PF12937.7 ELR14665.1 - 6.2e-14 51.6 0.6 6.2e-14 51.6 0.6 1.6 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 ELR14665.1 - 3.8e-08 33.0 0.2 6.5e-08 32.3 0.2 1.4 1 0 0 1 1 1 1 F-box domain F-box_5 PF18511.1 ELR14665.1 - 0.00019 20.9 0.3 0.0008 18.9 0.0 2.0 2 0 0 2 2 2 1 F-box F-box_4 PF15966.5 ELR14665.1 - 0.0019 18.0 0.1 0.0022 17.9 0.1 1.2 1 0 0 1 1 1 1 F-box Elongin_A PF06881.11 ELR14665.1 - 0.047 14.2 0.2 0.051 14.1 0.2 1.1 1 0 0 1 1 1 0 RNA polymerase II transcription factor SIII (Elongin) subunit A Anp1 PF03452.14 ELR14666.1 - 0.15 11.5 0.3 0.3 10.5 0.3 1.4 1 0 0 1 1 1 0 Anp1 Menin PF05053.13 ELR14667.1 - 2.6 6.3 16.2 0.02 13.3 7.9 1.6 2 0 0 2 2 2 0 Menin SPOUT_MTase PF02590.17 ELR14667.1 - 7.4 6.5 8.0 0.95 9.4 0.5 2.4 2 0 0 2 2 2 0 Predicted SPOUT methyltransferase DnaB_bind PF10410.9 ELR14668.1 - 0.045 14.0 0.2 0.2 11.9 0.2 2.2 1 0 0 1 1 1 0 DnaB-helicase binding domain of primase Myc_N PF01056.18 ELR14668.1 - 0.049 13.5 2.1 0.059 13.3 2.1 1.2 1 0 0 1 1 1 0 Myc amino-terminal region DNA_pol_phi PF04931.13 ELR14668.1 - 0.049 11.7 6.9 0.064 11.3 6.9 1.2 1 0 0 1 1 1 0 DNA polymerase phi FANCF PF11107.8 ELR14668.1 - 0.052 12.7 0.2 0.08 12.1 0.2 1.2 1 0 0 1 1 1 0 Fanconi anemia group F protein (FANCF) FAM176 PF14851.6 ELR14668.1 - 0.058 13.1 5.1 0.12 12.0 5.1 1.6 1 0 0 1 1 1 0 FAM176 family NOA36 PF06524.12 ELR14668.1 - 0.12 11.6 5.2 0.17 11.2 5.2 1.2 1 0 0 1 1 1 0 NOA36 protein PAC1 PF16094.5 ELR14668.1 - 0.43 9.7 3.3 0.68 9.0 3.3 1.2 1 0 0 1 1 1 0 Proteasome assembly chaperone 4 CENP-B_dimeris PF09026.10 ELR14668.1 - 2 8.9 13.4 4 7.9 13.4 1.5 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Peptidase_C1 PF00112.23 ELR14669.1 - 3.1e-51 174.6 5.9 4.6e-51 174.0 5.9 1.2 1 0 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.12 ELR14669.1 - 5.9e-18 65.0 1.3 1.1e-17 64.2 1.3 1.4 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) zf-UBP PF02148.19 ELR14670.1 - 3.8e-10 40.0 11.8 3.8e-10 40.0 11.8 3.4 2 1 1 3 3 3 1 Zn-finger in ubiquitin-hydrolases and other protein CrtC PF07143.11 ELR14670.1 - 0.084 13.5 0.2 0.14 12.8 0.2 1.3 1 0 0 1 1 1 0 CrtC N-terminal lipocalin domain GFO_IDH_MocA PF01408.22 ELR14671.1 - 2.2e-25 89.8 0.2 3.9e-25 89.0 0.2 1.4 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold F420_oxidored PF03807.17 ELR14671.1 - 0.0097 16.5 0.0 0.022 15.3 0.0 1.6 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent NAD_binding_3 PF03447.16 ELR14671.1 - 0.056 14.1 1.1 0.081 13.6 0.2 1.8 2 0 0 2 2 2 0 Homoserine dehydrogenase, NAD binding domain Glyco_hydro38C2 PF17677.1 ELR14672.1 - 6.4e-08 32.6 0.0 2.2e-07 30.9 0.0 1.9 2 0 0 2 2 2 1 Glycosyl hydrolases family 38 C-terminal beta sandwich domain Glyco_hydro_38C PF07748.13 ELR14672.1 - 2.9e-06 27.5 0.0 4.6e-06 26.9 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 C-terminal domain Alpha-mann_mid PF09261.11 ELR14673.1 - 7e-09 35.7 0.0 1.6e-08 34.5 0.0 1.6 1 0 0 1 1 1 1 Alpha mannosidase middle domain Glyco_hydro_38 PF18438.1 ELR14673.1 - 0.00083 19.4 0.0 0.0015 18.6 0.0 1.5 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 C-terminal domain 1 XRCC4 PF06632.12 ELR14673.1 - 0.42 9.4 13.7 0.58 9.0 13.7 1.1 1 0 0 1 1 1 0 DNA double-strand break repair and V(D)J recombination protein XRCC4 CDC45 PF02724.14 ELR14673.1 - 1.5 7.0 10.7 2 6.6 10.7 1.1 1 0 0 1 1 1 0 CDC45-like protein TFIIF_alpha PF05793.12 ELR14673.1 - 5.9 5.4 17.4 8 4.9 17.4 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Glyco_hydro_38N PF01074.22 ELR14674.1 - 1.8e-21 76.8 0.1 4.3e-21 75.6 0.0 1.6 2 0 0 2 2 2 1 Glycosyl hydrolases family 38 N-terminal domain Nup54 PF13874.6 ELR14674.1 - 0.12 12.5 3.3 0.19 11.8 3.3 1.3 1 0 0 1 1 1 0 Nucleoporin complex subunit 54 LIM PF00412.22 ELR14675.1 - 6.3e-09 35.9 6.0 9.5e-09 35.4 6.0 1.2 1 0 0 1 1 1 1 LIM domain Lar_restr_allev PF14354.6 ELR14675.1 - 0.24 11.8 7.9 5.8 7.4 7.9 2.4 1 1 0 1 1 1 0 Restriction alleviation protein Lar Ephrin_rec_like PF07699.13 ELR14675.1 - 0.24 11.2 7.3 5.8 6.8 3.6 2.5 2 1 0 2 2 2 0 Putative ephrin-receptor like Auto_anti-p27 PF06677.12 ELR14675.1 - 0.65 10.2 5.8 1 9.5 1.7 2.2 1 1 1 2 2 2 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) TNFR_c6 PF00020.18 ELR14675.1 - 5.5 7.5 10.6 28 5.2 0.1 3.5 2 1 0 2 2 2 0 TNFR/NGFR cysteine-rich region Hamartin PF04388.12 ELR14676.1 - 1.6 7.3 13.5 1.8 7.1 13.5 1.0 1 0 0 1 1 1 0 Hamartin protein Complex1_LYR PF05347.15 ELR14677.1 - 1.7e-11 44.0 0.2 2.4e-11 43.5 0.2 1.2 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_2 PF13233.6 ELR14677.1 - 0.052 14.3 0.0 0.07 13.9 0.0 1.4 1 0 0 1 1 1 0 Complex1_LYR-like CHCH PF06747.13 ELR14679.1 - 0.15 12.2 0.1 0.15 12.2 0.1 2.2 2 1 0 2 2 2 0 CHCH domain CX9C PF16860.5 ELR14679.1 - 0.36 10.9 3.4 0.52 10.4 0.6 2.0 2 0 0 2 2 2 0 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, tRNA-synt_2 PF00152.20 ELR14680.1 - 1.9e-79 267.0 0.0 2.3e-79 266.7 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 ELR14680.1 - 7.1e-05 22.7 0.0 0.00042 20.2 0.0 2.2 1 1 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.20 ELR14680.1 - 8.6e-05 22.1 0.1 0.18 11.2 0.0 2.9 3 0 0 3 3 3 2 tRNA synthetases class II core domain (F) RNA_pol_Rpb2_6 PF00562.28 ELR14681.1 - 2e-111 372.8 0.2 6e-111 371.3 0.2 1.7 1 1 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.15 ELR14681.1 - 5e-31 107.8 0.0 8.2e-31 107.1 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_3 PF04565.16 ELR14681.1 - 1.2e-28 99.0 0.0 2.7e-28 98.0 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_7 PF04560.20 ELR14681.1 - 3.3e-23 81.9 0.0 8.4e-23 80.6 0.0 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_2 PF04561.14 ELR14681.1 - 2e-20 73.2 0.0 4.4e-20 72.1 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpa2_4 PF06883.12 ELR14681.1 - 4.5e-18 65.0 0.0 9.6e-18 63.9 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase I, Rpa2 specific domain zf-Sec23_Sec24 PF04810.15 ELR14681.1 - 1.1 9.3 4.3 0.5 10.5 0.3 2.4 2 0 0 2 2 2 0 Sec23/Sec24 zinc finger MiAMP1 PF09117.10 ELR14682.1 - 0.29 11.4 7.1 0.59 10.4 0.5 2.5 1 1 1 2 2 2 0 MiAMP1 MSA-2c PF12238.8 ELR14683.1 - 0.0028 17.7 0.2 0.0028 17.7 0.2 1.8 2 0 0 2 2 2 1 Merozoite surface antigen 2c zf-C2H2 PF00096.26 ELR14683.1 - 0.0051 17.2 0.2 0.011 16.2 0.2 1.6 1 0 0 1 1 1 1 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 ELR14683.1 - 0.013 16.2 0.1 0.029 15.2 0.1 1.6 1 0 0 1 1 1 0 C2H2-type zinc finger DUF498 PF04430.14 ELR14685.1 - 6.8e-29 100.1 0.0 7.5e-29 100.0 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF498/DUF598) Pkinase PF00069.25 ELR14686.1 - 3.6e-63 213.4 0.0 4.7e-63 213.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR14686.1 - 5.3e-34 117.7 0.0 7.1e-34 117.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase PH PF00169.29 ELR14686.1 - 3.6e-05 24.2 0.0 8.5e-05 23.0 0.0 1.6 1 0 0 1 1 1 1 PH domain PH_3 PF14593.6 ELR14686.1 - 0.00021 21.3 0.0 0.00078 19.5 0.0 1.9 1 0 0 1 1 1 1 PH domain Kinase-like PF14531.6 ELR14686.1 - 0.0025 17.2 0.0 0.005 16.2 0.0 1.5 1 1 0 1 1 1 1 Kinase-like Pkinase_C PF00433.24 ELR14686.1 - 0.0054 17.4 0.0 0.012 16.3 0.0 1.6 1 0 0 1 1 1 1 Protein kinase C terminal domain APH PF01636.23 ELR14686.1 - 0.0088 16.0 0.0 0.014 15.3 0.0 1.5 1 1 0 1 1 1 1 Phosphotransferase enzyme family Pkinase PF00069.25 ELR14687.1 - 1.3e-72 244.4 0.0 1.8e-72 243.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR14687.1 - 8.4e-36 123.6 0.0 1.2e-35 123.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase PH PF00169.29 ELR14687.1 - 2.8e-19 69.6 0.1 5.3e-19 68.7 0.1 1.4 1 0 0 1 1 1 1 PH domain PH_11 PF15413.6 ELR14687.1 - 9e-07 29.3 0.6 8.8e-06 26.1 0.6 2.3 1 1 0 1 1 1 1 Pleckstrin homology domain PH_3 PF14593.6 ELR14687.1 - 2.6e-06 27.5 0.0 7.5e-06 26.0 0.0 1.8 1 0 0 1 1 1 1 PH domain Kinase-like PF14531.6 ELR14687.1 - 0.00026 20.4 0.0 0.044 13.1 0.0 2.2 1 1 0 2 2 2 2 Kinase-like PH_9 PF15410.6 ELR14687.1 - 0.0049 17.2 0.3 0.1 12.9 0.3 2.4 1 1 0 1 1 1 1 Pleckstrin homology domain Pkinase_C PF00433.24 ELR14687.1 - 0.025 15.3 0.0 0.063 14.0 0.0 1.7 1 0 0 1 1 1 0 Protein kinase C terminal domain APH PF01636.23 ELR14687.1 - 0.2 11.6 0.0 0.31 10.9 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family LRR_4 PF12799.7 ELR14688.1 - 0.046 14.2 10.1 3.2 8.3 1.4 5.6 4 3 2 6 6 6 0 Leucine Rich repeats (2 copies) Conotoxin PF02950.17 ELR14691.1 - 0.023 15.7 0.1 0.029 15.4 0.1 1.1 1 0 0 1 1 1 0 Conotoxin Carboxyl_trans PF01039.22 ELR14694.1 - 3.9e-164 546.9 0.3 1.2e-93 314.4 0.0 2.0 1 1 1 2 2 2 2 Carboxyl transferase domain MdcE PF06833.11 ELR14694.1 - 0.014 14.9 0.3 0.035 13.6 0.0 1.8 2 0 0 2 2 2 0 Malonate decarboxylase gamma subunit (MdcE) Big_1 PF02369.16 ELR14694.1 - 0.1 12.6 0.2 8.2 6.5 0.4 2.4 2 0 0 2 2 2 0 Bacterial Ig-like domain (group 1) CPSase_L_D2 PF02786.17 ELR14695.1 - 7.1e-82 274.0 0.1 1.3e-81 273.2 0.1 1.4 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Biotin_carb_N PF00289.22 ELR14695.1 - 1.9e-46 157.1 0.2 7.9e-46 155.1 0.1 2.1 2 0 0 2 2 2 1 Biotin carboxylase, N-terminal domain Biotin_carb_C PF02785.19 ELR14695.1 - 1.9e-36 124.5 0.0 5.7e-36 122.9 0.0 1.9 1 0 0 1 1 1 1 Biotin carboxylase C-terminal domain PCC_BT PF18140.1 ELR14695.1 - 4.5e-24 85.2 0.1 2.4e-23 82.9 0.1 2.1 1 1 0 1 1 1 1 Propionyl-coenzyme A carboxylase BT domain Biotin_lipoyl PF00364.22 ELR14695.1 - 1e-16 60.5 3.1 2.1e-16 59.5 3.1 1.6 1 0 0 1 1 1 1 Biotin-requiring enzyme Dala_Dala_lig_C PF07478.13 ELR14695.1 - 3.6e-09 36.5 0.0 1.4e-08 34.6 0.0 1.9 1 1 0 1 1 1 1 D-ala D-ala ligase C-terminus ATP-grasp PF02222.22 ELR14695.1 - 8e-07 28.8 0.0 2e-06 27.5 0.0 1.6 1 0 0 1 1 1 1 ATP-grasp domain ATP-grasp_3 PF02655.14 ELR14695.1 - 0.0014 18.7 0.0 0.0051 16.9 0.0 2.0 2 0 0 2 2 2 1 ATP-grasp domain RimK PF08443.11 ELR14695.1 - 0.0016 18.1 0.0 0.0095 15.6 0.0 2.1 1 1 0 1 1 1 1 RimK-like ATP-grasp domain HlyD_3 PF13437.6 ELR14695.1 - 0.0031 18.2 0.5 2.9 8.6 0.1 2.9 2 0 0 2 2 2 2 HlyD family secretion protein Biotin_lipoyl_2 PF13533.6 ELR14695.1 - 0.004 16.9 0.5 0.072 12.9 0.1 2.6 1 1 1 2 2 2 1 Biotin-lipoyl like ATP-grasp_5 PF13549.6 ELR14695.1 - 0.0069 15.9 0.4 0.035 13.6 0.0 2.2 2 0 0 2 2 2 1 ATP-grasp domain RnfC_N PF13375.6 ELR14695.1 - 0.032 14.2 0.2 0.43 10.6 0.2 2.7 3 0 0 3 3 3 0 RnfC Barrel sandwich hybrid domain GARS_A PF01071.19 ELR14695.1 - 0.05 13.4 0.8 0.079 12.7 0.0 1.7 2 0 0 2 2 2 0 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain HlyD_D23 PF16576.5 ELR14695.1 - 0.065 12.4 0.4 0.46 9.7 0.2 2.1 1 1 1 2 2 2 0 Barrel-sandwich domain of CusB or HlyD membrane-fusion GCV_H PF01597.19 ELR14695.1 - 0.097 12.6 0.2 0.28 11.1 0.2 1.7 1 0 0 1 1 1 0 Glycine cleavage H-protein Conotoxin PF02950.17 ELR14697.1 - 0.016 16.2 0.5 0.016 16.2 0.5 2.5 2 1 0 2 2 2 0 Conotoxin YL1 PF05764.13 ELR14697.1 - 0.08 13.1 14.1 0.11 12.5 14.1 1.2 1 0 0 1 1 1 0 YL1 nuclear protein SLAIN PF15301.6 ELR14697.1 - 0.094 11.9 6.2 0.12 11.6 6.2 1.0 1 0 0 1 1 1 0 SLAIN motif-containing family DNA_pol_phi PF04931.13 ELR14697.1 - 1.4 6.9 8.8 1.6 6.7 8.8 1.1 1 0 0 1 1 1 0 DNA polymerase phi Presenilin PF01080.17 ELR14697.1 - 1.8 7.3 3.6 2.1 7.0 3.6 1.2 1 0 0 1 1 1 0 Presenilin CENP-B_dimeris PF09026.10 ELR14697.1 - 6 7.3 13.0 13 6.2 13.0 1.7 1 0 0 1 1 1 0 Centromere protein B dimerisation domain INT_SG_DDX_CT_C PF15300.6 ELR14698.1 - 0.065 13.0 0.0 0.15 11.8 0.0 1.6 1 0 0 1 1 1 0 INTS6/SAGE1/DDX26B/CT45 C-terminus DUF4667 PF15700.5 ELR14698.1 - 1.8 8.6 8.4 2.6 8.1 2.3 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4667) SR-25 PF10500.9 ELR14698.1 - 6.1 6.4 25.2 0.72 9.4 6.3 2.5 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein EBP50_C PF09007.11 ELR14698.1 - 9.1 7.3 10.1 4.2 8.4 3.0 2.6 2 0 0 2 2 2 0 EBP50, C-terminal SDA1 PF05285.12 ELR14701.1 - 0.0044 16.5 12.1 0.0076 15.7 12.1 1.4 1 0 0 1 1 1 1 SDA1 Trp_oprn_chp PF09534.10 ELR14701.1 - 0.092 12.5 0.0 0.19 11.5 0.0 1.5 1 0 0 1 1 1 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) BUD22 PF09073.10 ELR14701.1 - 0.2 10.9 16.9 0.19 11.0 13.9 2.0 2 0 0 2 2 2 0 BUD22 BSP_II PF05432.11 ELR14701.1 - 0.38 10.4 25.3 0.056 13.1 21.1 1.7 2 0 0 2 2 2 0 Bone sialoprotein II (BSP-II) Radial_spoke PF04712.12 ELR14701.1 - 0.56 9.1 25.3 0.065 12.2 7.7 2.2 2 0 0 2 2 2 0 Radial spokehead-like protein Hid1 PF12722.7 ELR14701.1 - 1.2 7.2 6.4 1.8 6.6 6.4 1.2 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein DUF3438 PF11920.8 ELR14701.1 - 1.9 7.7 5.6 2.9 7.1 0.1 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF3438) Presenilin PF01080.17 ELR14701.1 - 5.7 5.6 8.5 10 4.8 8.5 1.4 1 0 0 1 1 1 0 Presenilin MAM33 PF02330.16 ELR14701.1 - 8.4 6.3 18.9 1.3 8.9 1.7 2.5 3 0 0 3 3 3 0 Mitochondrial glycoprotein Herpes_BBRF1 PF04793.12 ELR14702.1 - 0.048 12.7 0.1 0.048 12.7 0.1 1.1 1 0 0 1 1 1 0 BRRF1-like protein Capsid_N PF16903.5 ELR14706.1 - 9.4e-35 120.1 0.0 1.2e-34 119.8 0.0 1.1 1 0 0 1 1 1 1 Major capsid protein N-terminus Capsid_NCLDV PF04451.12 ELR14706.1 - 2.3e-15 56.9 1.7 1.2e-12 48.1 0.2 2.6 3 0 0 3 3 3 2 Large eukaryotic DNA virus major capsid protein KA1 PF02149.19 ELR14708.1 - 0.016 15.0 0.0 0.02 14.6 0.0 1.3 1 0 0 1 1 1 0 Kinase associated domain 1 Aminotran_1_2 PF00155.21 ELR14710.1 - 4.2e-36 124.9 0.0 5.1e-36 124.6 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_MocR PF12897.7 ELR14710.1 - 0.00011 21.1 0.0 0.00016 20.6 0.0 1.3 1 0 0 1 1 1 1 Alanine-glyoxylate amino-transferase Toxin_27 PF08099.11 ELR14710.1 - 0.34 11.1 1.0 0.71 10.0 0.2 1.9 2 0 0 2 2 2 0 Scorpion calcine family Syntaxin-6_N PF09177.11 ELR14711.1 - 5.5e-17 62.2 12.3 6.8e-12 45.8 0.1 3.8 2 2 1 3 3 3 2 Syntaxin 6, N-terminal Mei5 PF10376.9 ELR14711.1 - 0.19 11.6 7.1 0.25 11.2 7.1 1.3 1 0 0 1 1 1 0 Double-strand recombination repair protein CorA PF01544.18 ELR14711.1 - 0.25 10.6 4.4 0.39 10.0 4.4 1.3 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein COG2 PF06148.11 ELR14711.1 - 0.84 9.7 7.6 8.2 6.5 0.5 2.7 1 1 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 DUF1664 PF07889.12 ELR14711.1 - 3.8 7.6 6.0 2.3 8.3 2.6 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) CPSase_L_D2 PF02786.17 ELR14712.1 - 1.6e-73 246.7 0.0 2.5e-73 246.1 0.0 1.3 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Biotin_carb_C PF02785.19 ELR14712.1 - 5.4e-37 126.2 0.0 9.7e-37 125.4 0.0 1.4 1 0 0 1 1 1 1 Biotin carboxylase C-terminal domain Dala_Dala_lig_C PF07478.13 ELR14712.1 - 4.4e-11 42.7 0.0 8.4e-11 41.8 0.0 1.4 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus Biotin_carb_N PF00289.22 ELR14712.1 - 2.6e-10 40.8 0.1 7.4e-10 39.4 0.1 1.9 1 0 0 1 1 1 1 Biotin carboxylase, N-terminal domain Biotin_lipoyl PF00364.22 ELR14712.1 - 4.3e-09 36.1 0.9 1e-08 34.9 0.9 1.6 1 0 0 1 1 1 1 Biotin-requiring enzyme ATP-grasp PF02222.22 ELR14712.1 - 1.1e-05 25.0 0.0 2.1e-05 24.2 0.0 1.3 1 0 0 1 1 1 1 ATP-grasp domain Biotin_lipoyl_2 PF13533.6 ELR14712.1 - 0.00038 20.2 0.0 0.00088 19.1 0.0 1.5 1 0 0 1 1 1 1 Biotin-lipoyl like ATP-grasp_3 PF02655.14 ELR14712.1 - 0.0025 17.9 0.0 0.0057 16.7 0.0 1.6 1 1 0 1 1 1 1 ATP-grasp domain ATPgrasp_Ter PF15632.6 ELR14712.1 - 0.011 15.4 0.0 0.023 14.4 0.0 1.5 1 0 0 1 1 1 0 ATP-grasp in the biosynthetic pathway with Ter operon PPC PF04151.15 ELR14713.1 - 3.5e-06 28.0 14.4 0.26 12.4 0.1 7.8 8 0 0 8 8 8 2 Bacterial pre-peptidase C-terminal domain EGF_2 PF07974.13 ELR14713.1 - 0.00013 22.2 18.8 0.025 14.9 8.0 2.7 2 0 0 2 2 2 2 EGF-like domain TA_inhibitor PF17574.2 ELR14713.1 - 0.14 12.2 0.1 18 5.4 0.0 2.4 2 0 0 2 2 2 0 Inhibitor of toxin/antitoxin system (Gp4.5) Laminin_EGF PF00053.24 ELR14713.1 - 1.9 8.7 28.2 0.013 15.6 7.4 2.6 2 0 0 2 2 2 0 Laminin EGF domain EGF PF00008.27 ELR14713.1 - 3.2 8.1 22.6 0.5 10.7 1.4 3.0 3 0 0 3 3 3 0 EGF-like domain ECH_1 PF00378.20 ELR14714.1 - 4.3e-13 49.2 0.0 5.1e-13 48.9 0.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 ELR14714.1 - 1.1e-08 34.9 0.0 1.4e-08 34.6 0.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase Peptidase_C26 PF07722.13 ELR14715.1 - 0.0017 18.1 0.0 0.0022 17.8 0.0 1.1 1 0 0 1 1 1 1 Peptidase C26 LytR_C PF13399.6 ELR14715.1 - 0.089 13.8 1.3 15 6.7 0.8 2.1 2 0 0 2 2 2 0 LytR cell envelope-related transcriptional attenuator DUF1028 PF06267.12 ELR14715.1 - 0.1 12.4 0.5 0.12 12.2 0.5 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF1028) 2_5_RNA_ligase2 PF13563.6 ELR14716.1 - 7.8e-34 116.8 0.0 9.1e-34 116.6 0.0 1.0 1 0 0 1 1 1 1 2'-5' RNA ligase superfamily LigT_PEase PF02834.16 ELR14716.1 - 0.00014 22.0 0.0 0.17 12.1 0.0 2.2 2 0 0 2 2 2 2 LigT like Phosphoesterase Ank_3 PF13606.6 ELR14717.1 - 1.4e-08 34.3 0.0 0.28 11.8 0.0 5.1 4 1 1 5 5 5 2 Ankyrin repeat Ank_5 PF13857.6 ELR14717.1 - 3e-08 33.8 0.0 0.00029 21.1 0.1 3.0 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 ELR14717.1 - 3e-07 30.6 1.1 0.026 14.9 0.0 4.6 5 1 0 5 5 5 2 Ankyrin repeat Ank_4 PF13637.6 ELR14717.1 - 2.9e-06 27.7 0.1 0.016 15.7 0.0 3.5 1 1 3 4 4 4 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 ELR14717.1 - 3.2e-05 24.4 0.0 0.38 11.4 0.0 3.5 2 1 2 4 4 4 2 Ankyrin repeats (3 copies) Phage_TAC_7 PF10109.9 ELR14717.1 - 0.015 15.4 0.1 4.2 7.6 0.0 2.5 2 0 0 2 2 2 0 Phage tail assembly chaperone proteins, E, or 41 or 14 2_5_RNA_ligase2 PF13563.6 ELR14718.1 - 2.7e-39 134.5 0.3 8.4e-39 132.9 0.1 1.9 2 0 0 2 2 2 1 2'-5' RNA ligase superfamily LigT_PEase PF02834.16 ELR14718.1 - 4.4e-06 26.8 0.3 0.038 14.2 0.1 2.7 2 0 0 2 2 2 2 LigT like Phosphoesterase AKAP7_NLS PF10469.9 ELR14718.1 - 0.0032 17.4 0.0 0.012 15.5 0.0 1.9 2 1 1 3 3 3 1 AKAP7 2'5' RNA ligase-like domain Radical_SAM PF04055.21 ELR14719.1 - 1.6e-32 113.2 0.0 3.6e-32 112.0 0.0 1.6 1 0 0 1 1 1 1 Radical SAM superfamily UPF0004 PF00919.20 ELR14719.1 - 1.7e-32 111.4 0.4 3.5e-32 110.3 0.4 1.6 1 0 0 1 1 1 1 Uncharacterized protein family UPF0004 TRAM PF01938.20 ELR14719.1 - 3.5e-09 36.5 0.6 9.9e-09 35.1 0.6 1.8 1 1 0 1 1 1 1 TRAM domain PAG PF15347.6 ELR14719.1 - 0.031 13.3 0.1 0.049 12.6 0.1 1.2 1 0 0 1 1 1 0 Phosphoprotein associated with glycosphingolipid-enriched DUF4142 PF13628.6 ELR14719.1 - 0.13 12.5 0.2 0.3 11.3 0.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4142) PRCC PF10253.9 ELR14720.1 - 1.2 9.9 7.5 1.5 9.5 7.5 1.3 1 0 0 1 1 1 0 Mitotic checkpoint regulator, MAD2B-interacting DEAD PF00270.29 ELR14721.1 - 2.5e-18 66.4 0.0 4.3e-18 65.7 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ELR14721.1 - 9e-08 32.4 0.0 0.0013 19.1 0.0 3.6 2 2 0 2 2 2 2 Helicase conserved C-terminal domain Abhydrolase_1 PF00561.20 ELR14722.1 - 8e-10 38.8 0.0 2.3e-09 37.3 0.0 1.7 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 ELR14722.1 - 4.2e-08 34.1 1.2 1.2e-07 32.6 1.2 1.7 1 1 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 ELR14722.1 - 2.4e-06 27.0 0.0 7.4e-05 22.1 0.0 2.2 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Rit1_C PF17184.4 ELR14723.1 - 6.5e-58 196.3 0.1 3.9e-28 98.7 0.0 2.1 1 1 1 2 2 2 2 Rit1 N-terminal domain Init_tRNA_PT PF04179.12 ELR14723.1 - 1.6e-09 38.0 0.0 3e-09 37.2 0.0 1.4 1 0 0 1 1 1 1 Rit1 DUSP-like domain DUF4611 PF15387.6 ELR14723.1 - 1.8 8.9 6.4 5 7.4 6.4 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4611) ORC6 PF05460.13 ELR14724.1 - 1.9 7.6 9.2 0.18 11.0 4.8 1.6 2 0 0 2 2 2 0 Origin recognition complex subunit 6 (ORC6) UQ_con PF00179.26 ELR14725.1 - 1.1e-43 148.3 0.0 1.5e-43 147.8 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme ECH_1 PF00378.20 ELR14727.1 - 2.3e-51 174.5 0.1 2.8e-51 174.3 0.1 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 ELR14727.1 - 1.2e-27 97.3 0.1 1.4e-27 97.1 0.1 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase NOD PF06816.13 ELR14727.1 - 0.075 12.7 0.1 0.23 11.1 0.0 1.8 2 0 0 2 2 2 0 NOTCH protein RasGAP PF00616.19 ELR14728.1 - 2.4e-27 96.0 5.1 6.9e-18 65.1 0.0 3.7 2 1 1 3 3 3 2 GTPase-activator protein for Ras-like GTPase START PF01852.19 ELR14728.1 - 2.7e-20 72.7 0.0 6.3e-20 71.5 0.0 1.6 1 0 0 1 1 1 1 START domain Phosphoesterase PF04185.14 ELR14729.1 - 3.5e-66 223.8 0.0 6.3e-66 223.0 0.0 1.4 1 0 0 1 1 1 1 Phosphoesterase family Abhydrolase_6 PF12697.7 ELR14730.1 - 4.1e-10 40.6 6.7 7.7e-10 39.7 6.7 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 ELR14730.1 - 1.5e-09 37.9 0.0 3.1e-09 36.8 0.0 1.5 1 0 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 ELR14730.1 - 2.7e-09 36.6 0.0 6.4e-06 25.6 0.0 2.2 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Carboxyl_trans PF01039.22 ELR14731.1 - 7.6e-122 407.4 0.0 9.9e-122 407.1 0.0 1.0 1 0 0 1 1 1 1 Carboxyl transferase domain DSPc PF00782.20 ELR14732.1 - 0.041 13.7 0.0 5.6 6.8 0.0 2.1 1 1 1 2 2 2 0 Dual specificity phosphatase, catalytic domain HSP20 PF00011.21 ELR14733.1 - 7e-22 77.5 0.0 1e-21 76.9 0.0 1.2 1 0 0 1 1 1 1 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 ELR14733.1 - 2e-10 40.0 0.0 3.3e-10 39.4 0.0 1.3 1 0 0 1 1 1 1 HSP20-like domain found in ArsA CS PF04969.16 ELR14733.1 - 0.088 13.8 0.0 0.17 12.9 0.0 1.5 1 1 0 1 1 1 0 CS domain Metallophos PF00149.28 ELR14734.1 - 4.7e-10 40.3 0.2 7.5e-10 39.6 0.2 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 ELR14734.1 - 0.00021 21.5 0.0 0.00027 21.2 0.0 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain SF3b10 PF07189.11 ELR14735.1 - 5e-23 81.0 0.0 2.1e-22 79.0 0.0 1.7 1 1 1 2 2 2 1 Splicing factor 3B subunit 10 (SF3b10) FERM_f0 PF16511.5 ELR14736.1 - 1.2e-09 38.3 0.2 5.2e-06 26.7 0.1 2.3 2 0 0 2 2 2 2 N-terminal or F0 domain of Talin-head FERM PI3K_rbd PF00794.18 ELR14736.1 - 0.025 14.7 1.8 2.9 8.1 0.0 2.5 3 0 0 3 3 3 0 PI3-kinase family, ras-binding domain TUG-UBL1 PF11470.8 ELR14736.1 - 0.15 12.3 0.5 8.5 6.7 0.0 2.8 3 0 0 3 3 3 0 TUG ubiquitin-like domain RhoGAP PF00620.27 ELR14737.1 - 3.2e-14 53.0 0.0 9e-14 51.6 0.0 1.7 1 1 0 1 1 1 1 RhoGAP domain Bac_A_amyl_C PF18612.1 ELR14737.1 - 0.055 13.2 0.0 0.12 12.2 0.0 1.5 1 0 0 1 1 1 0 Bacterial Alpha amylase C-terminal domain zf-C2H2_jaz PF12171.8 ELR14738.1 - 2.2e-06 27.8 0.5 3.7e-06 27.1 0.5 1.4 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 ELR14738.1 - 4.9e-06 26.8 0.3 7.8e-06 26.1 0.3 1.3 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-U1 PF06220.12 ELR14738.1 - 0.14 11.9 0.9 0.28 11.0 0.9 1.5 1 0 0 1 1 1 0 U1 zinc finger CAP PF00188.26 ELR14739.1 - 3.3e-20 73.2 3.3 8.4e-20 71.9 3.3 1.7 1 1 0 1 1 1 1 Cysteine-rich secretory protein family Myticin-prepro PF10690.9 ELR14739.1 - 0.17 12.2 0.5 0.32 11.3 0.5 1.4 1 0 0 1 1 1 0 Myticin pre-proprotein from the mussel TALPID3 PF15324.6 ELR14739.1 - 1.9 6.0 6.3 2.4 5.7 6.3 1.0 1 0 0 1 1 1 0 Hedgehog signalling target Totivirus_coat PF05518.11 ELR14739.1 - 6.4 4.7 8.7 9.1 4.2 8.7 1.1 1 0 0 1 1 1 0 Totivirus coat protein CoaE PF01121.20 ELR14740.1 - 1.6e-50 171.2 0.0 1.9e-50 171.0 0.0 1.0 1 0 0 1 1 1 1 Dephospho-CoA kinase AAA_18 PF13238.6 ELR14740.1 - 0.003 18.1 1.5 0.064 13.8 1.5 2.2 1 1 0 1 1 1 1 AAA domain Cytidylate_kin2 PF13189.6 ELR14740.1 - 0.0063 16.7 0.2 0.011 15.9 0.2 1.4 1 0 0 1 1 1 1 Cytidylate kinase-like family dNK PF01712.19 ELR14740.1 - 0.064 13.1 0.4 1.4 8.8 0.4 2.6 1 1 0 1 1 1 0 Deoxynucleoside kinase PRK PF00485.18 ELR14740.1 - 0.071 12.8 0.7 0.35 10.6 0.1 2.0 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family AAA_28 PF13521.6 ELR14740.1 - 0.078 13.2 0.2 0.2 11.9 0.2 1.8 1 1 0 1 1 1 0 AAA domain CLP1_P PF16575.5 ELR14740.1 - 0.17 11.7 0.0 0.66 9.7 0.0 1.9 2 1 0 2 2 2 0 mRNA cleavage and polyadenylation factor CLP1 P-loop Pox_MCEL PF03291.16 ELR14741.1 - 6.9e-33 114.1 0.0 1.3e-32 113.3 0.0 1.4 1 1 0 1 1 1 1 mRNA capping enzyme Methyltransf_25 PF13649.6 ELR14741.1 - 4.1e-09 37.0 0.1 1.1e-08 35.6 0.1 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ELR14741.1 - 6.4e-06 26.7 0.2 4.2e-05 24.1 0.1 2.2 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 ELR14741.1 - 0.00022 21.9 0.0 0.00048 20.8 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ELR14741.1 - 0.0024 17.7 0.0 0.0038 17.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 ELR14741.1 - 0.0086 15.6 0.0 0.015 14.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain PKD PF00801.20 ELR14742.1 - 2.4e-21 75.3 4.0 4.3e-10 39.3 0.9 2.5 2 0 0 2 2 2 2 PKD domain Saf_2TM PF18303.1 ELR14742.1 - 0.039 13.5 0.0 0.068 12.8 0.0 1.3 1 0 0 1 1 1 0 SAVED-fused 2TM effector domain Glyco_transf_8 PF01501.20 ELR14743.1 - 2.7e-08 33.7 0.3 1.7e-07 31.1 0.3 2.0 1 1 0 1 1 1 1 Glycosyl transferase family 8 MCR_gamma PF02240.16 ELR14743.1 - 0.1 11.8 0.0 8.4 5.6 0.0 2.2 2 0 0 2 2 2 0 Methyl-coenzyme M reductase gamma subunit Mannosyl_trans3 PF11051.8 ELR14743.1 - 0.11 11.8 0.0 0.17 11.2 0.0 1.2 1 0 0 1 1 1 0 Mannosyltransferase putative Pkinase_Tyr PF07714.17 ELR14744.1 - 5.4e-124 412.6 0.0 5.2e-61 206.2 0.0 2.6 3 0 0 3 3 3 2 Protein tyrosine kinase Pkinase PF00069.25 ELR14744.1 - 1.5e-108 362.1 0.0 2.4e-55 187.8 0.0 2.9 3 0 0 3 3 3 2 Protein kinase domain PBP_like_2 PF12849.7 ELR14744.1 - 1.9e-19 70.4 6.6 1.5e-11 44.5 0.5 2.8 3 0 0 3 3 3 2 PBP superfamily domain Guanylate_cyc PF00211.20 ELR14744.1 - 2.8e-15 56.4 0.0 5.1e-15 55.6 0.0 1.4 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain APH PF01636.23 ELR14744.1 - 2.3e-07 31.0 0.1 0.0002 21.4 0.0 2.5 2 0 0 2 2 2 2 Phosphotransferase enzyme family Haspin_kinase PF12330.8 ELR14744.1 - 0.00013 21.0 0.1 0.015 14.3 0.0 2.4 2 0 0 2 2 2 1 Haspin like kinase domain EGF_2 PF07974.13 ELR14744.1 - 0.00055 20.2 12.4 0.0011 19.3 12.4 1.5 1 0 0 1 1 1 1 EGF-like domain Kinase-like PF14531.6 ELR14744.1 - 0.0014 18.0 0.0 0.3 10.4 0.0 2.8 3 0 0 3 3 3 1 Kinase-like FTA2 PF13095.6 ELR14744.1 - 0.0063 16.2 0.0 3.3 7.3 0.0 3.1 2 1 1 3 3 3 1 Kinetochore Sim4 complex subunit FTA2 RIO1 PF01163.22 ELR14744.1 - 0.008 15.8 0.4 1.5 8.4 0.2 2.3 2 0 0 2 2 2 1 RIO1 family Pkinase_fungal PF17667.1 ELR14744.1 - 0.018 13.8 0.0 4.8 5.9 0.0 2.3 2 0 0 2 2 2 0 Fungal protein kinase ABC-3 PF00950.17 ELR14744.1 - 0.036 13.6 0.3 0.066 12.7 0.3 1.3 1 0 0 1 1 1 0 ABC 3 transport family Hormone_5 PF00184.17 ELR14744.1 - 0.12 13.2 4.4 0.28 12.0 4.4 1.6 1 0 0 1 1 1 0 Neurohypophysial hormones, C-terminal Domain Kdo PF06293.14 ELR14744.1 - 0.21 10.9 0.1 4.2 6.7 0.0 2.2 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family hEGF PF12661.7 ELR14744.1 - 1.1 10.0 4.5 2.7 8.7 4.5 1.7 1 0 0 1 1 1 0 Human growth factor-like EGF EGF_Tenascin PF18720.1 ELR14744.1 - 1.7 8.7 6.2 4 7.6 6.2 1.6 1 0 0 1 1 1 0 Tenascin EGF domain EGF PF00008.27 ELR14744.1 - 3 8.2 8.6 6.4 7.2 8.6 1.6 1 0 0 1 1 1 0 EGF-like domain LIM PF00412.22 ELR14745.1 - 1.5e-07 31.5 1.7 2.7e-07 30.7 1.7 1.3 1 0 0 1 1 1 1 LIM domain TNFR_c6 PF00020.18 ELR14745.1 - 9.2 6.8 8.6 0.91 10.0 1.7 3.1 2 1 0 2 2 2 0 TNFR/NGFR cysteine-rich region Peptidase_M3 PF01432.20 ELR14746.1 - 7e-115 384.9 0.0 8.2e-115 384.7 0.0 1.0 1 0 0 1 1 1 1 Peptidase family M3 Peptidase_M50B PF13398.6 ELR14746.1 - 0.066 12.8 0.5 0.12 12.0 0.5 1.4 1 0 0 1 1 1 0 Peptidase M50B-like Zn_clus PF00172.18 ELR14747.1 - 1.2e-08 35.0 11.4 1.8e-08 34.3 11.4 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain ArfGap PF01412.18 ELR14750.1 - 6.7e-38 129.4 0.0 9.4e-38 128.9 0.0 1.1 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf zf-dskA_traR PF01258.17 ELR14750.1 - 1.9 8.5 7.4 1.7 8.7 0.2 3.4 4 0 0 4 4 4 0 Prokaryotic dksA/traR C4-type zinc finger PIG-P PF08510.12 ELR14751.1 - 7.5e-20 71.1 2.6 1.2e-12 47.8 5.1 2.1 1 1 1 2 2 2 2 PIG-P Mito_carr PF00153.27 ELR14752.1 - 1.3e-52 175.7 1.1 4.1e-20 71.5 0.1 3.3 3 0 0 3 3 3 3 Mitochondrial carrier protein Pyrophosphatase PF00719.19 ELR14752.1 - 2.5e-42 144.4 0.1 3.7e-42 143.8 0.1 1.2 1 0 0 1 1 1 1 Inorganic pyrophosphatase E2R135 PF11570.8 ELR14752.1 - 0.13 12.5 0.1 0.23 11.8 0.1 1.3 1 0 0 1 1 1 0 Coiled-coil receptor-binding R-domain of colicin E2 DUF3148 PF11347.8 ELR14753.1 - 0.13 12.0 0.0 0.23 11.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3148) Glyco_transf_92 PF01697.27 ELR14754.1 - 0.019 14.6 0.1 0.12 12.0 0.0 1.8 2 0 0 2 2 2 0 Glycosyltransferase family 92 CE2_N PF17996.1 ELR14755.1 - 2.8e-09 36.9 0.1 3.7e-07 30.1 0.1 2.5 1 1 0 1 1 1 1 Carbohydrate esterase 2 N-terminal Glyco_transf_92 PF01697.27 ELR14756.1 - 0.039 13.6 0.1 0.13 11.9 0.1 1.9 1 1 0 1 1 1 0 Glycosyltransferase family 92 Glyco_tran_WbsX PF14307.6 ELR14757.1 - 2.7e-71 240.9 6.2 4.6e-71 240.1 6.2 1.4 1 0 0 1 1 1 1 Glycosyltransferase WbsX DUF5087 PF17006.5 ELR14758.1 - 0.18 11.3 0.0 0.27 10.7 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF5087) ATG16 PF08614.11 ELR14759.1 - 0.007 16.6 11.7 0.007 16.6 11.7 1.4 1 1 0 1 1 1 1 Autophagy protein 16 (ATG16) CENP-Q PF13094.6 ELR14759.1 - 0.029 14.6 0.3 0.029 14.6 0.3 2.3 1 1 0 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit Sec8_exocyst PF04048.14 ELR14759.1 - 0.038 13.9 6.3 2.3 8.1 2.0 2.9 2 1 1 3 3 3 0 Sec8 exocyst complex component specific domain YgaB PF14182.6 ELR14759.1 - 0.082 13.3 9.0 0.46 10.9 1.4 2.8 1 1 0 2 2 2 0 YgaB-like protein BLOC1_2 PF10046.9 ELR14759.1 - 0.12 12.7 5.4 3 8.2 0.3 2.3 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Fez1 PF06818.15 ELR14759.1 - 0.17 12.3 14.1 0.21 12.0 14.1 1.0 1 0 0 1 1 1 0 Fez1 BST2 PF16716.5 ELR14759.1 - 0.19 12.4 8.2 0.47 11.1 8.3 1.7 1 1 0 1 1 1 0 Bone marrow stromal antigen 2 Bacillus_HBL PF05791.11 ELR14759.1 - 0.24 11.2 7.5 0.26 11.1 6.5 1.5 1 1 1 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) Spc7 PF08317.11 ELR14759.1 - 0.37 9.6 13.1 0.25 10.2 9.7 1.8 1 1 1 2 2 2 0 Spc7 kinetochore protein DUF1664 PF07889.12 ELR14759.1 - 0.75 9.8 6.6 0.83 9.7 2.8 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) Occludin_ELL PF07303.13 ELR14759.1 - 1.1 10.0 5.4 12 6.7 0.8 2.7 1 1 2 3 3 3 0 Occludin homology domain MCU PF04678.13 ELR14759.1 - 1.2 9.3 5.9 0.83 9.7 4.2 1.5 1 1 1 2 2 2 0 Mitochondrial calcium uniporter ABC_tran_Xtn PF12848.7 ELR14759.1 - 1.9 8.6 10.7 0.092 12.8 4.7 1.9 2 0 0 2 2 2 0 ABC transporter Atg14 PF10186.9 ELR14759.1 - 5.7 5.9 12.2 8.9 5.3 12.2 1.4 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 FGGY_N PF00370.21 ELR14760.1 - 5.5e-38 130.9 0.0 1.6e-36 126.2 0.0 2.5 1 1 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain FGGY_C PF02782.16 ELR14760.1 - 1.5e-14 54.2 0.0 2.8e-14 53.3 0.0 1.4 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain DivIC PF04977.15 ELR14760.1 - 0.041 13.7 3.3 0.073 12.9 3.3 1.3 1 0 0 1 1 1 0 Septum formation initiator Glu_synthase PF01645.17 ELR14760.1 - 0.11 11.6 0.0 0.22 10.6 0.0 1.4 1 0 0 1 1 1 0 Conserved region in glutamate synthase DUF1640 PF07798.11 ELR14760.1 - 0.36 10.9 1.2 0.53 10.3 1.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1640) Fungal_TACC PF12709.7 ELR14760.1 - 0.4 11.2 2.3 0.72 10.3 2.3 1.3 1 0 0 1 1 1 0 Fungal Transforming acidic coiled-coil (TACC) proteins PIG-L PF02585.17 ELR14762.1 - 3.1e-26 92.5 0.0 4.2e-26 92.1 0.0 1.2 1 0 0 1 1 1 1 GlcNAc-PI de-N-acetylase Ras PF00071.22 ELR14763.1 - 9.4e-26 90.3 0.0 1.5e-25 89.7 0.0 1.3 1 1 0 1 1 1 1 Ras family Roc PF08477.13 ELR14763.1 - 1.1e-07 32.0 0.1 4.4e-07 30.1 0.1 1.9 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase RsgA_GTPase PF03193.16 ELR14763.1 - 2.6e-07 30.7 0.3 0.00047 20.1 0.0 2.1 2 0 0 2 2 2 2 RsgA GTPase Arf PF00025.21 ELR14763.1 - 0.0001 21.8 0.0 0.00013 21.4 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 ELR14763.1 - 0.0016 18.0 0.0 0.0033 17.0 0.0 1.5 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 ELR14763.1 - 0.019 15.1 0.1 0.053 13.6 0.1 1.7 1 1 0 1 1 1 0 50S ribosome-binding GTPase ArsA_ATPase PF02374.15 ELR14763.1 - 0.021 14.0 0.0 1.1 8.4 0.0 2.0 2 0 0 2 2 2 0 Anion-transporting ATPase NB-ARC PF00931.22 ELR14763.1 - 0.049 12.8 0.2 0.072 12.3 0.2 1.3 1 0 0 1 1 1 0 NB-ARC domain AAA_16 PF13191.6 ELR14763.1 - 0.074 13.4 0.2 0.088 13.2 0.2 1.5 1 1 0 1 1 1 0 AAA ATPase domain AAA_24 PF13479.6 ELR14763.1 - 0.18 11.5 0.0 0.23 11.2 0.0 1.2 1 0 0 1 1 1 0 AAA domain RabGAP-TBC PF00566.18 ELR14764.1 - 2.1e-50 171.4 2.3 3e-50 170.8 2.3 1.3 1 0 0 1 1 1 1 Rab-GTPase-TBC domain Shisa PF13908.6 ELR14764.1 - 0.00012 22.4 1.4 0.00023 21.4 1.4 1.4 1 0 0 1 1 1 1 Wnt and FGF inhibitory regulator Tmemb_9 PF05434.11 ELR14764.1 - 0.029 14.2 0.4 0.087 12.7 0.4 1.8 1 0 0 1 1 1 0 TMEM9 LST1 PF05083.13 ELR14764.1 - 0.14 12.5 0.7 0.43 10.9 0.7 1.8 1 0 0 1 1 1 0 LST-1 protein HemY_N PF07219.13 ELR14764.1 - 0.25 11.5 2.9 1 9.6 2.9 2.0 1 0 0 1 1 1 0 HemY protein N-terminus PP2C PF00481.21 ELR14766.1 - 1.9e-49 168.7 0.0 2.2e-49 168.4 0.0 1.0 1 0 0 1 1 1 1 Protein phosphatase 2C SpoIIE PF07228.12 ELR14766.1 - 1.6e-06 28.2 0.2 1e-05 25.6 0.2 2.0 1 1 0 1 1 1 1 Stage II sporulation protein E (SpoIIE) PP2C_2 PF13672.6 ELR14766.1 - 0.0013 18.4 0.1 0.013 15.1 0.1 2.5 1 1 0 1 1 1 1 Protein phosphatase 2C DUF5018 PF16410.5 ELR14766.1 - 0.15 10.8 0.0 0.2 10.3 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5018) Mito_carr PF00153.27 ELR14767.1 - 7e-25 86.8 0.3 7.5e-18 64.3 0.0 2.1 2 0 0 2 2 2 2 Mitochondrial carrier protein Alpha-amylase PF00128.24 ELR14768.1 - 2e-11 44.1 0.0 2.8e-07 30.4 0.0 2.4 2 1 0 2 2 2 2 Alpha amylase, catalytic domain DUF3459 PF11941.8 ELR14768.1 - 7.3e-05 23.0 0.3 0.00022 21.5 0.3 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF3459) Alpha-amylase_C PF02806.18 ELR14768.1 - 0.00053 20.4 0.0 0.0016 18.8 0.0 1.9 1 0 0 1 1 1 1 Alpha amylase, C-terminal all-beta domain Malt_amylase_C PF16657.5 ELR14768.1 - 0.00084 19.4 0.0 0.0058 16.7 0.0 2.2 2 0 0 2 2 2 1 Maltogenic Amylase, C-terminal domain MerC PF03203.14 ELR14770.1 - 0.11 12.9 0.4 0.23 11.9 0.4 1.5 1 0 0 1 1 1 0 MerC mercury resistance protein ORMDL PF04061.14 ELR14772.1 - 0.06 13.2 0.2 0.12 12.2 0.2 1.4 1 0 0 1 1 1 0 ORMDL family NLPC_P60 PF00877.19 ELR14772.1 - 0.074 13.1 0.0 0.15 12.1 0.0 1.5 1 0 0 1 1 1 0 NlpC/P60 family IU_nuc_hydro PF01156.19 ELR14773.1 - 1.3e-40 139.9 0.0 1.8e-40 139.4 0.0 1.1 1 0 0 1 1 1 1 Inosine-uridine preferring nucleoside hydrolase MCM PF00493.23 ELR14774.1 - 1.1e-101 338.6 0.0 1.6e-101 338.1 0.0 1.2 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 ELR14774.1 - 2e-28 98.8 0.2 3.7e-28 97.9 0.2 1.4 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 ELR14774.1 - 2.2e-20 72.8 2.2 6.3e-20 71.4 0.0 2.8 4 0 0 4 4 4 1 MCM AAA-lid domain MCM_N PF14551.6 ELR14774.1 - 1.8e-09 38.1 0.0 3.7e-09 37.1 0.0 1.6 1 0 0 1 1 1 1 MCM N-terminal domain Mg_chelatase PF01078.21 ELR14774.1 - 1.7e-07 30.8 0.3 2.7e-05 23.7 0.0 2.5 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 ELR14774.1 - 7.5e-07 29.2 0.0 2.1e-06 27.8 0.0 1.8 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.11 ELR14774.1 - 0.0066 16.3 0.0 0.031 14.1 0.0 2.2 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 ELR14774.1 - 0.024 15.0 0.3 1.2 9.5 0.2 3.0 2 1 0 2 2 2 0 AAA ATPase domain DUF1364 PF07102.12 ELR14774.1 - 0.061 13.2 0.0 0.18 11.7 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1364) UCH PF00443.29 ELR14775.1 - 4.6e-40 137.7 0.0 1.5e-39 136.0 0.0 1.9 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 ELR14775.1 - 4.4e-16 59.4 0.7 3.2e-14 53.3 0.1 2.8 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase HEPN_RiboL-PSP PF18735.1 ELR14775.1 - 0.28 11.1 9.3 0.12 12.3 0.3 2.8 2 1 0 2 2 2 0 RiboL-PSP-HEPN CCDC53 PF10152.9 ELR14775.1 - 0.42 11.0 4.2 0.49 10.8 0.1 2.5 2 0 0 2 2 2 0 Subunit CCDC53 of WASH complex DUF357 PF04010.13 ELR14775.1 - 1.4 9.0 5.1 9.2 6.4 0.1 3.6 4 0 0 4 4 4 0 Protein of unknown function (DUF357) HSP20 PF00011.21 ELR14776.1 - 1.5e-16 60.4 0.3 1.5e-16 60.4 0.3 4.5 4 4 2 6 6 6 1 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 ELR14776.1 - 2.2e-06 27.1 0.1 6.9e-06 25.5 0.1 1.9 1 1 0 1 1 1 1 HSP20-like domain found in ArsA Kelch_1 PF01344.25 ELR14777.1 - 3.5e-28 96.9 14.4 5.7e-10 38.6 0.0 5.4 6 0 0 6 6 6 4 Kelch motif Kelch_4 PF13418.6 ELR14777.1 - 2.4e-27 94.7 13.2 5.4e-06 26.3 0.0 6.1 6 0 0 6 6 6 5 Galactose oxidase, central domain Kelch_6 PF13964.6 ELR14777.1 - 3.6e-26 90.5 9.2 4.7e-06 26.7 0.0 5.5 4 1 1 5 5 5 4 Kelch motif Kelch_5 PF13854.6 ELR14777.1 - 3.3e-24 84.4 11.4 1.5e-05 24.9 0.0 6.4 6 0 0 6 6 6 5 Kelch motif Kelch_3 PF13415.6 ELR14777.1 - 1.1e-23 82.9 5.2 1.2e-07 31.9 0.1 7.2 7 0 0 7 7 7 4 Galactose oxidase, central domain Kelch_2 PF07646.15 ELR14777.1 - 5e-22 77.0 12.1 4.2e-06 26.5 0.2 6.2 7 1 0 7 7 7 4 Kelch motif F-box-like PF12937.7 ELR14777.1 - 4.7e-05 23.2 0.7 0.0001 22.1 0.7 1.6 1 0 0 1 1 1 1 F-box-like DUF1668 PF07893.13 ELR14777.1 - 0.015 14.6 0.2 0.68 9.2 0.0 2.5 1 1 2 3 3 3 0 Protein of unknown function (DUF1668) ADK PF00406.22 ELR14778.1 - 1.7e-56 190.5 0.0 2e-56 190.3 0.0 1.1 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 ELR14778.1 - 3.6e-24 85.7 0.2 1.6e-23 83.6 0.1 1.9 2 0 0 2 2 2 1 AAA domain ADK_lid PF05191.14 ELR14778.1 - 3.3e-17 62.2 0.0 6.6e-17 61.2 0.0 1.6 1 0 0 1 1 1 1 Adenylate kinase, active site lid AAA_33 PF13671.6 ELR14778.1 - 3.7e-07 30.4 0.0 6.8e-07 29.5 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 ELR14778.1 - 0.00034 21.2 0.0 0.0006 20.4 0.0 1.4 1 0 0 1 1 1 1 AAA domain Hydin_ADK PF17213.3 ELR14778.1 - 0.0081 16.5 0.1 0.17 12.1 0.0 2.2 1 1 1 2 2 2 1 Hydin Adenylate kinase-like domain SRP54 PF00448.22 ELR14778.1 - 0.015 15.0 0.0 0.021 14.5 0.0 1.3 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain AAA_28 PF13521.6 ELR14778.1 - 0.032 14.5 0.0 0.048 13.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain Cytidylate_kin PF02224.18 ELR14778.1 - 0.043 13.5 0.0 0.087 12.5 0.0 1.4 1 1 0 1 1 1 0 Cytidylate kinase ELP6 PF09807.9 ELR14779.1 - 1.6e-45 155.5 0.0 2e-45 155.2 0.0 1.0 1 0 0 1 1 1 1 Elongation complex protein 6 Elong_Iki1 PF10483.9 ELR14779.1 - 1.6e-08 34.4 0.0 6.9e-08 32.3 0.0 1.8 1 1 0 1 1 1 1 Elongator subunit Iki1 RMMBL PF07521.12 ELR14779.1 - 0.016 15.1 0.0 0.04 13.9 0.0 1.6 1 0 0 1 1 1 0 Zn-dependent metallo-hydrolase RNA specificity domain DNA_pol3_delta PF06144.13 ELR14779.1 - 0.032 14.0 0.0 0.049 13.4 0.0 1.2 1 0 0 1 1 1 0 DNA polymerase III, delta subunit NAD_binding_10 PF13460.6 ELR14779.1 - 0.082 12.8 0.0 0.19 11.6 0.0 1.6 2 0 0 2 2 2 0 NAD(P)H-binding PPR_2 PF13041.6 ELR14780.1 - 7.4e-68 224.6 0.1 8.8e-12 45.0 0.1 11.6 3 1 9 12 12 12 11 PPR repeat family PPR PF01535.20 ELR14780.1 - 1.4e-57 188.0 7.4 5.6e-07 29.4 0.1 12.3 12 0 0 12 12 12 11 PPR repeat PPR_1 PF12854.7 ELR14780.1 - 1.5e-54 181.4 0.0 1.1e-09 37.8 0.0 11.2 11 0 0 11 11 11 9 PPR repeat PPR_3 PF13812.6 ELR14780.1 - 4.4e-48 161.2 0.1 4.4e-10 39.5 0.0 7.6 6 1 2 8 8 8 6 Pentatricopeptide repeat domain PPR_long PF17177.4 ELR14780.1 - 2.9e-30 105.2 3.5 1.4e-08 34.4 0.0 5.8 2 1 4 6 6 6 5 Pentacotripeptide-repeat region of PRORP TPR_19 PF14559.6 ELR14780.1 - 9.7e-07 29.2 2.0 0.0023 18.4 0.0 4.7 5 0 0 5 5 4 1 Tetratricopeptide repeat ATP13 PF12921.7 ELR14780.1 - 1.1e-06 28.4 0.0 2 8.3 0.0 5.3 4 2 0 4 4 4 1 Mitochondrial ATPase expression TPR_14 PF13428.6 ELR14780.1 - 1.1e-06 28.9 7.3 0.14 13.1 0.0 7.6 7 1 1 8 8 7 1 Tetratricopeptide repeat ECSIT PF06239.11 ELR14780.1 - 6.5e-06 25.4 0.1 0.2 10.8 0.0 4.8 2 2 2 4 4 4 1 Evolutionarily conserved signalling intermediate in Toll pathway Wzy_C_2 PF11846.8 ELR14780.1 - 0.00032 20.7 0.3 5 7.0 0.0 4.7 3 2 1 5 5 5 1 Virulence factor membrane-bound polymerase, C-terminal TPR_4 PF07721.14 ELR14780.1 - 0.0015 18.9 12.2 1.1 10.0 0.2 6.1 7 0 0 7 7 6 2 Tetratricopeptide repeat Clathrin PF00637.20 ELR14780.1 - 0.053 13.4 0.0 11 5.9 0.0 4.0 4 1 0 4 4 4 0 Region in Clathrin and VPS Glyco_trans_4_3 PF12000.8 ELR14780.1 - 0.054 13.2 0.3 24 4.5 0.0 4.0 4 2 1 5 5 5 0 Glycosyl transferase family 4 group COX5A PF02284.16 ELR14780.1 - 0.056 13.5 0.1 2.7 8.0 0.0 3.5 3 0 0 3 3 3 0 Cytochrome c oxidase subunit Va DUF3368 PF11848.8 ELR14780.1 - 0.066 13.0 0.6 17 5.3 0.0 4.1 4 0 0 4 4 4 0 Domain of unknown function (DUF3368) TPR_16 PF13432.6 ELR14780.1 - 0.091 13.4 1.1 16 6.2 0.0 3.9 4 0 0 4 4 3 0 Tetratricopeptide repeat AP_endonuc_2 PF01261.24 ELR14780.1 - 0.1 12.0 1.5 12 5.3 0.0 3.5 2 1 1 3 3 3 0 Xylose isomerase-like TIM barrel Snf7 PF03357.21 ELR14781.1 - 5.5e-24 84.7 7.9 5.5e-24 84.7 7.9 1.8 2 0 0 2 2 2 1 Snf7 Not3 PF04065.15 ELR14781.1 - 0.0027 17.2 6.6 0.0051 16.3 6.6 1.5 1 1 0 1 1 1 1 Not1 N-terminal domain, CCR4-Not complex component GrpE PF01025.19 ELR14781.1 - 0.026 14.2 6.9 0.019 14.6 5.2 1.6 1 1 0 1 1 1 0 GrpE DUF3399 PF11879.8 ELR14781.1 - 0.16 12.3 0.4 0.41 11.0 0.4 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3399) Novirhabdo_Nv PF05554.11 ELR14781.1 - 0.18 11.6 0.0 0.33 10.7 0.0 1.3 1 0 0 1 1 1 0 Viral hemorrhagic septicemia virus non-virion protein PIGA PF08288.12 ELR14783.1 - 2.6e-37 127.3 0.3 5.1e-37 126.3 0.3 1.5 1 0 0 1 1 1 1 PIGA (GPI anchor biosynthesis) Glyco_transf_4 PF13439.6 ELR14783.1 - 1e-30 107.0 0.3 1.5e-30 106.4 0.3 1.3 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glycos_transf_1 PF00534.20 ELR14783.1 - 1.9e-15 56.8 0.2 4.2e-12 45.9 0.2 2.4 1 1 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 ELR14783.1 - 4.2e-14 53.1 1.0 1.3e-11 45.0 1.0 2.6 1 1 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.6 ELR14783.1 - 4.4e-10 40.2 0.0 9.9e-10 39.1 0.0 1.6 1 0 0 1 1 1 1 Glycosyl transferase 4-like domain Glyco_trans_4_2 PF13477.6 ELR14783.1 - 2e-06 27.9 0.1 3.8e-06 27.0 0.1 1.4 1 0 0 1 1 1 1 Glycosyl transferase 4-like Ssl1 PF04056.14 ELR14784.1 - 2.6e-63 213.3 0.0 6.5e-38 130.5 0.0 2.1 1 1 1 2 2 2 2 Ssl1-like C1_4 PF07975.12 ELR14784.1 - 1.1e-13 51.2 2.7 3e-13 49.8 2.7 1.8 1 0 0 1 1 1 1 TFIIH C1-like domain VWA_2 PF13519.6 ELR14784.1 - 1.3e-05 25.8 0.0 3.4e-05 24.4 0.0 1.7 1 1 1 2 2 2 1 von Willebrand factor type A domain zf-C2H2 PF00096.26 ELR14784.1 - 4.7 7.9 0.0 4.7 7.9 0.0 3.6 3 1 0 3 3 3 0 Zinc finger, C2H2 type RasGEF PF00617.19 ELR14785.1 - 7.1e-58 195.7 0.1 1.4e-57 194.7 0.1 1.5 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 ELR14785.1 - 1.3e-22 80.0 4.2 1.3e-22 80.0 2.0 2.1 2 0 0 2 2 2 1 RasGEF N-terminal motif Mad3_BUB1_I PF08311.12 ELR14785.1 - 0.043 13.8 0.0 0.12 12.4 0.0 1.7 1 0 0 1 1 1 0 Mad3/BUB1 homology region 1 Peptidase_C80 PF11713.8 ELR14785.1 - 0.13 12.5 0.0 0.41 10.9 0.0 1.8 1 1 1 2 2 2 0 Peptidase C80 family cobW PF02492.19 ELR14787.1 - 1.2e-20 73.9 0.4 5e-15 55.5 0.0 2.3 1 1 1 2 2 2 2 CobW/HypB/UreG, nucleotide-binding domain CobW_C PF07683.14 ELR14787.1 - 1.5e-19 69.7 0.2 5.5e-19 67.9 0.0 2.0 2 0 0 2 2 2 1 Cobalamin synthesis protein cobW C-terminal domain GTP_EFTU PF00009.27 ELR14787.1 - 0.0041 16.7 0.1 0.026 14.0 0.0 2.1 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain Arf PF00025.21 ELR14787.1 - 0.0049 16.3 0.5 0.15 11.5 0.2 2.4 2 0 0 2 2 2 1 ADP-ribosylation factor family NACHT PF05729.12 ELR14787.1 - 0.0084 16.0 0.0 0.016 15.2 0.0 1.5 1 0 0 1 1 1 1 NACHT domain AAA_16 PF13191.6 ELR14787.1 - 0.01 16.2 0.8 0.02 15.3 0.1 1.9 2 0 0 2 2 2 0 AAA ATPase domain RsgA_GTPase PF03193.16 ELR14787.1 - 0.012 15.5 0.5 0.73 9.7 0.1 2.3 2 0 0 2 2 2 0 RsgA GTPase ATP_bind_1 PF03029.17 ELR14787.1 - 0.013 15.3 2.0 0.67 9.7 0.2 2.4 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein AAA_28 PF13521.6 ELR14787.1 - 0.033 14.4 0.0 0.14 12.3 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_22 PF13401.6 ELR14787.1 - 0.035 14.4 0.0 0.11 12.7 0.0 1.9 2 0 0 2 2 2 0 AAA domain Hamartin PF04388.12 ELR14787.1 - 0.67 8.6 6.7 0.91 8.1 6.7 1.1 1 0 0 1 1 1 0 Hamartin protein I_LWEQ PF01608.17 ELR14787.1 - 7.3 6.8 11.2 0.84 9.9 4.1 2.6 3 0 0 3 3 3 0 I/LWEQ domain Nup160 PF11715.8 ELR14789.1 - 2.7e-37 128.6 0.0 4.4e-37 127.9 0.0 1.3 1 0 0 1 1 1 1 Nucleoporin Nup120/160 TPR_2 PF07719.17 ELR14789.1 - 0.026 14.6 0.4 0.17 12.1 0.0 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_1 PF00515.28 ELR14789.1 - 0.045 13.6 0.2 0.31 10.9 0.0 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_8 PF13181.6 ELR14789.1 - 0.11 12.8 0.0 0.75 10.2 0.0 2.6 1 0 0 1 1 1 0 Tetratricopeptide repeat ChAPs PF09295.10 ELR14789.1 - 0.11 11.4 0.1 0.41 9.6 0.1 1.8 1 1 1 2 2 2 0 ChAPs (Chs5p-Arf1p-binding proteins) ANAPC3 PF12895.7 ELR14789.1 - 0.64 10.3 4.4 1.1 9.6 0.2 3.4 4 0 0 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 PF13176.6 ELR14789.1 - 1.8 8.7 5.5 2.7 8.2 0.1 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat HEAT_2 PF13646.6 ELR14790.1 - 1.5e-08 34.9 1.5 0.013 15.9 0.3 4.2 4 0 0 4 4 4 2 HEAT repeats HEAT PF02985.22 ELR14790.1 - 8.6e-05 22.5 6.7 0.1 12.9 0.2 5.5 5 0 0 5 5 5 1 HEAT repeat RICTOR_V PF14668.6 ELR14790.1 - 0.00074 19.7 0.2 0.0043 17.2 0.0 2.4 3 0 0 3 3 3 1 Rapamycin-insensitive companion of mTOR, domain 5 Arm PF00514.23 ELR14790.1 - 0.0073 16.3 0.3 0.0073 16.3 0.3 5.6 7 0 0 7 7 7 1 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.6 ELR14790.1 - 0.018 15.5 1.0 0.018 15.5 1.0 5.0 5 2 1 6 6 6 0 HEAT-like repeat Cnd1 PF12717.7 ELR14790.1 - 0.02 14.9 0.2 0.17 11.9 0.2 2.6 1 1 0 1 1 1 0 non-SMC mitotic condensation complex subunit 1 Mito_carr PF00153.27 ELR14792.1 - 1.8e-48 162.4 1.9 4.3e-18 65.0 0.0 4.0 3 1 0 3 3 3 3 Mitochondrial carrier protein DIM1 PF02966.16 ELR14793.1 - 1.9e-49 166.8 0.0 2.2e-49 166.6 0.0 1.0 1 0 0 1 1 1 1 Mitosis protein DIM1 Thioredoxin PF00085.20 ELR14793.1 - 0.00053 19.9 0.0 0.00072 19.5 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_6 PF13848.6 ELR14793.1 - 0.019 14.9 0.0 0.024 14.5 0.0 1.1 1 0 0 1 1 1 0 Thioredoxin-like domain DUF4768 PF15989.5 ELR14793.1 - 0.12 12.3 0.1 0.21 11.6 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4768) ArfGap PF01412.18 ELR14794.1 - 7.9e-39 132.4 0.1 7.9e-39 132.4 0.1 2.5 2 0 0 2 2 2 1 Putative GTPase activating protein for Arf PH PF00169.29 ELR14794.1 - 5.9e-25 87.8 9.9 1.4e-14 54.5 0.2 3.6 4 0 0 4 4 4 2 PH domain tRNA_int_endo PF01974.17 ELR14794.1 - 4e-15 55.7 0.0 8e-15 54.7 0.0 1.5 1 0 0 1 1 1 1 tRNA intron endonuclease, catalytic C-terminal domain PH_9 PF15410.6 ELR14794.1 - 2.5e-05 24.6 0.0 0.037 14.4 0.0 2.9 2 0 0 2 2 2 2 Pleckstrin homology domain PH_11 PF15413.6 ELR14794.1 - 3e-05 24.4 0.1 3e-05 24.4 0.1 3.5 4 0 0 4 4 4 1 Pleckstrin homology domain Presenilin PF01080.17 ELR14794.1 - 0.027 13.2 0.9 0.054 12.2 0.9 1.4 1 0 0 1 1 1 0 Presenilin Ank_4 PF13637.6 ELR14795.1 - 1.5e-17 63.7 0.0 2.2e-14 53.6 0.0 2.7 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.30 ELR14795.1 - 2.3e-15 56.3 0.1 1.4e-08 34.8 0.1 3.3 4 0 0 4 4 4 2 Ankyrin repeat Ank_2 PF12796.7 ELR14795.1 - 2.8e-15 56.7 0.1 2.1e-07 31.4 0.0 2.1 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 ELR14795.1 - 7.7e-15 54.8 0.2 2e-10 40.7 0.1 2.3 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 ELR14795.1 - 1.8e-13 49.3 0.1 3.1e-07 30.2 0.0 2.9 3 0 0 3 3 3 2 Ankyrin repeat SQS_PSY PF00494.19 ELR14796.1 - 7.5e-56 189.5 0.0 1.2e-55 188.9 0.0 1.3 1 0 0 1 1 1 1 Squalene/phytoene synthase Amino_oxidase PF01593.24 ELR14797.1 - 1.5e-24 87.1 0.0 1.1e-23 84.3 0.0 1.9 2 0 0 2 2 2 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 ELR14797.1 - 5.7e-14 52.1 0.1 2.3e-13 50.1 0.0 2.1 2 0 0 2 2 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 ELR14797.1 - 1.1e-12 48.2 0.0 4.3e-07 29.8 0.0 2.2 2 0 0 2 2 2 2 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 ELR14797.1 - 8.9e-10 38.3 0.0 2.8e-08 33.3 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 ELR14797.1 - 7.1e-06 25.3 0.0 0.00011 21.4 0.0 2.0 2 0 0 2 2 2 1 FAD binding domain FAD_oxidored PF12831.7 ELR14797.1 - 0.0003 20.3 0.0 0.00052 19.5 0.0 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase Thi4 PF01946.17 ELR14797.1 - 0.0003 20.1 0.0 0.00051 19.3 0.0 1.4 1 0 0 1 1 1 1 Thi4 family AlaDh_PNT_C PF01262.21 ELR14797.1 - 0.00033 20.0 1.1 0.00061 19.1 1.1 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain NAD_binding_9 PF13454.6 ELR14797.1 - 0.0016 18.4 0.7 0.014 15.4 0.1 2.1 2 0 0 2 2 2 1 FAD-NAD(P)-binding HI0933_like PF03486.14 ELR14797.1 - 0.0023 16.7 0.2 0.0065 15.2 0.3 1.6 2 0 0 2 2 2 1 HI0933-like protein MCRA PF06100.11 ELR14797.1 - 0.0047 15.8 0.0 0.0076 15.1 0.0 1.3 1 0 0 1 1 1 1 MCRA family GIDA PF01134.22 ELR14797.1 - 0.0074 15.4 1.8 0.28 10.2 0.7 2.1 2 0 0 2 2 2 1 Glucose inhibited division protein A Pyr_redox PF00070.27 ELR14797.1 - 0.02 15.4 1.0 0.056 14.0 1.0 1.7 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 ELR14797.1 - 0.041 13.1 0.5 0.041 13.1 0.5 1.6 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 ELR14797.1 - 0.053 12.8 0.5 0.087 12.0 0.5 1.3 1 0 0 1 1 1 0 FAD binding domain Lycopene_cycl PF05834.12 ELR14797.1 - 0.064 12.3 0.2 0.13 11.3 0.2 1.5 1 0 0 1 1 1 0 Lycopene cyclase protein Trp_halogenase PF04820.14 ELR14797.1 - 0.15 10.9 2.3 0.3 9.9 0.6 2.0 2 0 0 2 2 2 0 Tryptophan halogenase PRC PF05239.16 ELR14797.1 - 0.16 12.0 0.1 0.39 10.8 0.1 1.6 1 0 0 1 1 1 0 PRC-barrel domain Sacchrp_dh_NADP PF03435.18 ELR14797.1 - 0.24 11.6 0.4 0.61 10.4 0.2 1.7 2 0 0 2 2 1 0 Saccharopine dehydrogenase NADP binding domain VIR_N PF15912.5 ELR14798.1 - 4.9 6.7 9.7 6.2 6.3 9.7 1.3 1 0 0 1 1 1 0 Virilizer, N-terminal Mito_carr PF00153.27 ELR14799.1 - 9.3e-20 70.4 0.0 3.1e-12 46.2 0.0 2.8 2 0 0 2 2 2 2 Mitochondrial carrier protein DivIC PF04977.15 ELR14799.1 - 0.0085 15.8 2.5 0.0085 15.8 2.5 19.0 6 6 13 21 21 21 2 Septum formation initiator Drf_FH3 PF06367.16 ELR14800.1 - 0.026 14.2 0.5 0.036 13.7 0.5 1.1 1 0 0 1 1 1 0 Diaphanous FH3 Domain DUF3148 PF11347.8 ELR14800.1 - 0.19 11.5 0.0 0.34 10.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3148) DUF4407 PF14362.6 ELR14800.1 - 0.28 10.5 1.3 0.37 10.1 1.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Peptidase_S74 PF13884.6 ELR14801.1 - 2.9e-14 53.1 0.0 6.4e-14 52.0 0.0 1.6 1 0 0 1 1 1 1 Chaperone of endosialidase ODV-E18 PF10717.9 ELR14801.1 - 0.0063 16.3 0.6 0.021 14.7 0.6 1.8 1 0 0 1 1 1 1 Occlusion-derived virus envelope protein ODV-E18 Mucin PF01456.17 ELR14801.1 - 0.038 14.0 5.8 0.21 11.6 0.1 2.5 2 0 0 2 2 2 0 Mucin-like glycoprotein DUF2721 PF11026.8 ELR14801.1 - 0.1 12.5 0.1 0.2 11.5 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2721) DUF2207 PF09972.9 ELR14801.1 - 0.15 10.8 0.2 0.79 8.4 0.0 1.6 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) SRP-alpha_N PF04086.13 ELR14801.1 - 0.24 11.3 0.0 0.24 11.3 0.0 2.4 2 1 0 2 2 2 0 Signal recognition particle, alpha subunit, N-terminal ETRAMP PF09716.10 ELR14801.1 - 0.4 10.8 2.2 0.6 10.2 0.0 2.3 3 0 0 3 3 3 0 Malarial early transcribed membrane protein (ETRAMP) Ndc1_Nup PF09531.10 ELR14801.1 - 1.9 7.1 7.7 3.6 6.2 7.7 1.4 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup DUF4834 PF16118.5 ELR14801.1 - 7.3 7.6 0.0 7.3 7.6 0.0 3.9 3 1 1 4 4 4 0 Domain of unknown function (DUF4834) GATA PF00320.27 ELR14802.1 - 5e-12 45.2 7.8 1e-11 44.2 7.8 1.6 1 0 0 1 1 1 1 GATA zinc finger Zn-ribbon_8 PF09723.10 ELR14802.1 - 0.029 14.5 0.9 0.081 13.1 0.9 1.8 1 0 0 1 1 1 0 Zinc ribbon domain AAA PF00004.29 ELR14803.1 - 1.5e-38 132.2 0.0 3e-38 131.2 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Vps4_C PF09336.10 ELR14803.1 - 1.3e-11 44.3 0.0 3.2e-11 43.1 0.0 1.7 1 0 0 1 1 1 1 Vps4 C terminal oligomerisation domain AAA_lid_3 PF17862.1 ELR14803.1 - 1.2e-08 34.6 0.0 3.4e-08 33.1 0.0 1.8 1 0 0 1 1 1 1 AAA+ lid domain MIT PF04212.18 ELR14803.1 - 3.8e-08 33.3 8.5 2.7e-07 30.5 8.5 2.3 1 1 0 1 1 1 1 MIT (microtubule interacting and transport) domain AAA_5 PF07728.14 ELR14803.1 - 9.5e-08 32.1 0.1 9.2e-07 28.9 0.0 2.6 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) RuvB_N PF05496.12 ELR14803.1 - 2.6e-06 27.2 0.0 5.6e-05 22.9 0.0 2.4 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_2 PF07724.14 ELR14803.1 - 7.6e-05 22.9 0.2 0.00093 19.4 0.0 2.3 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_16 PF13191.6 ELR14803.1 - 0.00016 22.1 3.2 0.046 14.1 0.0 3.5 2 1 0 3 3 3 1 AAA ATPase domain AAA_14 PF13173.6 ELR14803.1 - 0.00035 20.6 0.0 0.001 19.1 0.0 1.7 2 0 0 2 2 1 1 AAA domain IstB_IS21 PF01695.17 ELR14803.1 - 0.0024 17.6 0.0 0.0084 15.9 0.0 1.9 2 0 0 2 2 2 1 IstB-like ATP binding protein AAA_22 PF13401.6 ELR14803.1 - 0.0034 17.6 0.7 0.36 11.1 0.0 2.9 2 1 1 3 3 2 1 AAA domain AAA_25 PF13481.6 ELR14803.1 - 0.0075 15.9 0.3 1 8.9 0.1 2.5 1 1 1 2 2 2 1 AAA domain AAA_24 PF13479.6 ELR14803.1 - 0.0084 15.8 0.0 0.017 14.9 0.0 1.4 1 0 0 1 1 1 1 AAA domain TIP49 PF06068.13 ELR14803.1 - 0.0098 15.1 0.0 0.016 14.5 0.0 1.2 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_33 PF13671.6 ELR14803.1 - 0.011 15.9 0.0 0.051 13.7 0.0 2.2 2 1 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 ELR14803.1 - 0.011 16.0 0.0 0.03 14.7 0.0 1.9 1 0 0 1 1 1 0 RNA helicase AAA_18 PF13238.6 ELR14803.1 - 0.012 16.2 0.0 0.031 14.8 0.0 1.8 1 1 0 1 1 1 0 AAA domain Mg_chelatase PF01078.21 ELR14803.1 - 0.014 14.8 0.0 0.043 13.2 0.0 1.8 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI TPR_7 PF13176.6 ELR14803.1 - 0.016 15.2 0.4 0.066 13.3 0.2 2.2 2 0 0 2 2 1 0 Tetratricopeptide repeat NACHT PF05729.12 ELR14803.1 - 0.02 14.8 0.0 3 7.7 0.0 2.5 1 1 1 2 2 2 0 NACHT domain Sigma54_activat PF00158.26 ELR14803.1 - 0.022 14.5 0.0 0.16 11.7 0.0 2.4 2 1 0 2 2 2 0 Sigma-54 interaction domain DUF815 PF05673.13 ELR14803.1 - 0.023 13.9 0.0 0.043 13.0 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF815) TPR_2 PF07719.17 ELR14803.1 - 0.027 14.6 0.3 0.027 14.6 0.3 2.7 3 0 0 3 3 2 0 Tetratricopeptide repeat TPR_1 PF00515.28 ELR14803.1 - 0.028 14.2 0.8 0.08 12.8 0.8 1.8 1 0 0 1 1 1 0 Tetratricopeptide repeat Methyltransf_32 PF13679.6 ELR14803.1 - 0.033 14.2 0.2 6.9 6.6 0.0 2.3 2 0 0 2 2 2 0 Methyltransferase domain AAA_7 PF12775.7 ELR14803.1 - 0.085 12.4 0.0 0.23 10.9 0.0 1.8 1 1 0 1 1 1 0 P-loop containing dynein motor region Parvo_NS1 PF01057.17 ELR14803.1 - 0.1 11.7 0.0 0.18 10.9 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 Torsin PF06309.11 ELR14803.1 - 0.22 11.6 0.4 0.41 10.7 0.0 1.6 2 0 0 2 2 1 0 Torsin ATPase_2 PF01637.18 ELR14803.1 - 0.85 9.5 2.4 2.2 8.1 0.0 2.5 2 1 1 3 3 3 0 ATPase domain predominantly from Archaea Mito_carr PF00153.27 ELR14804.1 - 2.8e-09 36.8 0.2 6.6e-09 35.6 0.2 1.6 1 0 0 1 1 1 1 Mitochondrial carrier protein Mito_carr PF00153.27 ELR14805.1 - 2.4e-52 174.8 4.8 7e-23 80.4 0.2 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein CENP-T_C PF15511.6 ELR14806.1 - 8.2e-09 35.6 0.1 1e-08 35.2 0.1 1.2 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold CENP-S PF15630.6 ELR14806.1 - 0.0001 22.6 0.1 0.00014 22.2 0.1 1.3 1 1 0 1 1 1 1 CENP-S protein TAF PF02969.17 ELR14806.1 - 0.00015 21.8 0.2 0.00021 21.4 0.2 1.3 1 1 0 1 1 1 1 TATA box binding protein associated factor (TAF) Histone PF00125.24 ELR14806.1 - 0.00026 21.4 0.1 0.00029 21.2 0.1 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 ELR14806.1 - 0.00062 20.0 0.1 0.00095 19.4 0.1 1.4 1 1 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID-31kDa PF02291.15 ELR14806.1 - 0.0079 16.3 0.0 0.0094 16.0 0.0 1.1 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit Bromo_TP PF07524.13 ELR14806.1 - 0.01 15.8 0.0 0.014 15.4 0.0 1.2 1 0 0 1 1 1 0 Bromodomain associated HIGH_NTase1_ass PF16581.5 ELR14806.1 - 0.09 12.8 0.1 0.1 12.6 0.1 1.1 1 0 0 1 1 1 0 Cytidyltransferase-related C-terminal region UPF0137 PF03677.13 ELR14806.1 - 0.11 12.3 0.1 0.14 12.0 0.1 1.0 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0137) TAFII28 PF04719.14 ELR14806.1 - 0.14 12.3 0.0 0.17 12.0 0.0 1.2 1 0 0 1 1 1 0 hTAFII28-like protein conserved region WD40 PF00400.32 ELR14807.1 - 4.6e-30 103.2 13.3 4.4e-06 27.3 0.0 7.8 8 0 0 8 8 7 6 WD domain, G-beta repeat PQQ_3 PF13570.6 ELR14807.1 - 8.2e-08 32.5 0.9 0.41 11.2 0.1 6.2 6 0 0 6 6 6 1 PQQ-like domain Nup160 PF11715.8 ELR14807.1 - 5.7e-06 25.3 2.2 0.15 10.7 0.0 3.3 3 0 0 3 3 3 3 Nucleoporin Nup120/160 WD40_like PF17005.5 ELR14807.1 - 1.7e-05 24.3 0.2 0.067 12.5 0.0 3.3 2 2 1 3 3 3 2 WD40-like domain zf-TRAF PF02176.18 ELR14807.1 - 2.4e-05 24.9 4.8 5.5e-05 23.8 4.8 1.7 1 0 0 1 1 1 1 TRAF-type zinc finger Nucleoporin_N PF08801.11 ELR14807.1 - 0.00033 19.5 0.6 0.019 13.7 0.0 2.7 2 1 1 3 3 3 1 Nup133 N terminal like Sina PF03145.16 ELR14807.1 - 0.00072 19.6 4.8 0.23 11.4 1.5 2.2 1 1 1 2 2 2 2 Seven in absentia protein family BBS2_Mid PF14783.6 ELR14807.1 - 0.0023 17.9 0.0 6.3 6.9 0.0 4.1 4 1 0 4 4 4 1 Ciliary BBSome complex subunit 2, middle region ANAPC4_WD40 PF12894.7 ELR14807.1 - 0.026 14.8 0.4 2.5 8.5 0.0 3.5 3 1 1 4 4 4 0 Anaphase-promoting complex subunit 4 WD40 domain Fib_alpha PF08702.10 ELR14807.1 - 0.063 13.5 0.0 0.12 12.5 0.0 1.3 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family Drf_FH3 PF06367.16 ELR14807.1 - 0.2 11.3 0.2 0.36 10.4 0.2 1.3 1 0 0 1 1 1 0 Diaphanous FH3 Domain DM PF00751.18 ELR14807.1 - 0.37 10.7 5.5 0.33 10.9 0.3 3.1 3 1 1 4 4 4 0 DM DNA binding domain Opy2 PF09463.10 ELR14807.1 - 2.9 8.3 5.8 6.6 7.1 5.8 1.6 1 0 0 1 1 1 0 Opy2 protein FRG1 PF06229.12 ELR14808.1 - 2.6e-09 37.1 0.0 5.7e-05 22.9 0.0 4.2 3 1 1 4 4 4 3 FRG1-like domain Fascin PF06268.13 ELR14808.1 - 2.2e-08 34.3 0.0 0.00061 20.0 0.0 4.8 3 2 1 6 6 6 3 Fascin domain DUF569 PF04601.13 ELR14808.1 - 0.0084 15.8 0.0 0.089 12.5 0.0 2.5 2 1 0 2 2 2 1 Domain of unknown function (DUF569) tRNA-synt_1e PF01406.19 ELR14809.1 - 5.3e-120 400.3 0.2 2e-119 398.4 0.2 1.8 1 1 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain tRNA-synt_1g PF09334.11 ELR14809.1 - 6.5e-08 31.7 1.2 0.00027 19.8 0.0 2.3 2 0 0 2 2 2 2 tRNA synthetases class I (M) DALR_2 PF09190.11 ELR14809.1 - 0.00099 19.5 0.1 0.01 16.3 0.0 2.7 2 0 0 2 2 2 1 DALR domain tRNA-synt_1 PF00133.22 ELR14809.1 - 0.0011 17.3 0.0 0.018 13.3 0.0 2.5 2 0 0 2 2 2 1 tRNA synthetases class I (I, L, M and V) DUF3585 PF12130.8 ELR14809.1 - 0.0032 17.6 4.8 0.0075 16.4 2.1 2.5 2 0 0 2 2 2 1 Bivalent Mical/EHBP Rab binding domain DALR_1 PF05746.15 ELR14809.1 - 0.021 15.0 7.6 0.043 14.0 0.1 3.6 3 0 0 3 3 3 0 DALR anticodon binding domain tRNA-synt_1f PF01921.18 ELR14809.1 - 0.038 12.9 0.1 0.35 9.7 0.0 2.2 2 0 0 2 2 2 0 tRNA synthetases class I (K) DUF4164 PF13747.6 ELR14809.1 - 0.81 10.0 8.3 0.41 11.0 1.9 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4164) DUF4192 PF13830.6 ELR14809.1 - 1.3 9.0 7.5 7.5 6.5 0.2 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4192) Fzo_mitofusin PF04799.13 ELR14809.1 - 3.5 7.1 6.2 0.31 10.6 0.8 1.9 2 0 0 2 2 2 0 fzo-like conserved region BSP_II PF05432.11 ELR14810.1 - 1.3 8.6 22.2 7.7 6.1 22.1 1.9 1 1 0 1 1 1 0 Bone sialoprotein II (BSP-II) PBP1_TM PF14812.6 ELR14810.1 - 2.1 8.8 8.9 0.83 10.1 0.4 3.4 3 0 0 3 3 3 0 Transmembrane domain of transglycosylase PBP1 at N-terminal SUV3_C PF12513.8 ELR14811.1 - 4.8e-15 55.2 1.0 1e-14 54.2 1.0 1.6 1 0 0 1 1 1 1 Mitochondrial degradasome RNA helicase subunit C terminal Helicase_C PF00271.31 ELR14811.1 - 6.4e-10 39.4 0.5 1.5e-09 38.2 0.0 1.8 2 0 0 2 2 2 1 Helicase conserved C-terminal domain Suv3_C_1 PF18147.1 ELR14811.1 - 9.1e-07 28.6 0.2 2.7e-06 27.2 0.0 1.9 2 0 0 2 2 2 1 Suv3 C-terminal domain 1 SCAI PF12070.8 ELR14812.1 - 1.4e-114 383.9 0.0 2e-113 380.1 0.0 2.4 1 1 0 1 1 1 1 Protein SCAI Glyco_H_20C_C PF18088.1 ELR14812.1 - 0.046 13.6 0.1 1.4 8.8 0.0 2.2 2 0 0 2 2 2 0 Glycoside Hydrolase 20C C-terminal domain SCAI PF12070.8 ELR14813.1 - 6.7e-40 137.5 5.8 7.5e-40 137.3 5.8 1.0 1 0 0 1 1 1 1 Protein SCAI EMC3_TMCO1 PF01956.16 ELR14814.1 - 6.1e-30 104.2 0.1 8.5e-30 103.7 0.1 1.1 1 0 0 1 1 1 1 Integral membrane protein EMC3/TMCO1-like Folate_carrier PF01770.18 ELR14814.1 - 0.079 11.7 0.8 0.087 11.5 0.8 1.3 1 1 0 1 1 1 0 Reduced folate carrier Tho2 PF11262.8 ELR14814.1 - 0.12 11.5 0.7 0.17 11.1 0.7 1.1 1 0 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 WD40 PF00400.32 ELR14816.1 - 3.6e-06 27.6 0.2 0.00017 22.3 0.0 3.2 3 0 0 3 3 3 1 WD domain, G-beta repeat Zip PF02535.22 ELR14816.1 - 0.026 13.8 2.0 0.025 13.8 2.0 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter MDM1 PF15501.6 ELR14816.1 - 0.041 13.0 6.6 0.059 12.5 6.6 1.2 1 0 0 1 1 1 0 Nuclear protein MDM1 DUF2722 PF10846.8 ELR14816.1 - 0.05 12.6 12.7 0.067 12.1 12.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) SDA1 PF05285.12 ELR14816.1 - 0.13 11.7 21.5 0.21 11.0 21.5 1.4 1 0 0 1 1 1 0 SDA1 Nop14 PF04147.12 ELR14816.1 - 0.14 10.4 25.8 0.18 10.0 25.8 1.2 1 0 0 1 1 1 0 Nop14-like family RR_TM4-6 PF06459.12 ELR14816.1 - 0.41 10.4 15.7 0.029 14.2 10.8 1.5 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 DUF5423 PF17461.2 ELR14816.1 - 1.3 7.8 5.2 2 7.2 5.2 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5423) Pox_Ag35 PF03286.14 ELR14816.1 - 2.8 7.7 17.9 5.9 6.6 17.9 1.6 1 0 0 1 1 1 0 Pox virus Ag35 surface protein MCM_bind PF09739.9 ELR14816.1 - 4 5.8 10.3 5.8 5.2 10.3 1.2 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor Presenilin PF01080.17 ELR14816.1 - 5.1 5.8 7.7 7 5.3 7.7 1.2 1 0 0 1 1 1 0 Presenilin NPR3 PF03666.13 ELR14816.1 - 6.1 5.5 12.0 8.5 5.0 12.0 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 BUD22 PF09073.10 ELR14816.1 - 6.6 6.0 29.9 10 5.3 29.9 1.2 1 0 0 1 1 1 0 BUD22 Tim54 PF11711.8 ELR14816.1 - 6.6 5.4 9.8 10 4.8 9.8 1.2 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 CDC45 PF02724.14 ELR14816.1 - 9.7 4.3 21.1 14 3.8 21.1 1.2 1 0 0 1 1 1 0 CDC45-like protein NTPase_1 PF03266.15 ELR14817.1 - 1.1e-34 119.7 0.0 1.6e-33 116.0 0.0 1.9 1 1 0 1 1 1 1 NTPase NACHT PF05729.12 ELR14817.1 - 4.8e-05 23.3 0.0 6.9e-05 22.8 0.0 1.3 1 0 0 1 1 1 1 NACHT domain AAA_16 PF13191.6 ELR14817.1 - 0.00011 22.6 0.1 0.00018 22.0 0.1 1.4 1 0 0 1 1 1 1 AAA ATPase domain AAA_19 PF13245.6 ELR14817.1 - 0.00012 22.4 0.2 0.00025 21.4 0.1 1.7 2 0 0 2 2 1 1 AAA domain AAA_22 PF13401.6 ELR14817.1 - 0.00064 20.0 0.0 0.00091 19.5 0.0 1.5 1 1 0 1 1 1 1 AAA domain AAA_30 PF13604.6 ELR14817.1 - 0.00095 18.9 0.6 0.0014 18.4 0.6 1.5 1 1 0 1 1 1 1 AAA domain MeaB PF03308.16 ELR14817.1 - 0.0013 17.8 0.2 0.002 17.2 0.2 1.2 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA PF00004.29 ELR14817.1 - 0.007 16.8 0.0 0.028 14.9 0.1 2.0 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 ELR14817.1 - 0.0077 16.2 0.1 0.03 14.3 0.1 1.8 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_25 PF13481.6 ELR14817.1 - 0.0087 15.6 0.1 0.013 15.1 0.1 1.3 1 0 0 1 1 1 1 AAA domain Zeta_toxin PF06414.12 ELR14817.1 - 0.013 14.8 0.3 0.021 14.1 0.3 1.4 1 0 0 1 1 1 0 Zeta toxin Viral_helicase1 PF01443.18 ELR14817.1 - 0.016 14.9 0.2 0.068 12.9 0.1 1.9 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase AAA_18 PF13238.6 ELR14817.1 - 0.017 15.7 0.1 0.026 15.1 0.1 1.3 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 ELR14817.1 - 0.024 14.8 0.1 0.045 13.9 0.1 1.4 1 0 0 1 1 1 0 AAA domain AAA_14 PF13173.6 ELR14817.1 - 0.034 14.2 0.0 0.54 10.3 0.1 2.1 2 0 0 2 2 2 0 AAA domain AAA_29 PF13555.6 ELR14817.1 - 0.059 13.1 0.0 0.1 12.3 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain TrwB_AAD_bind PF10412.9 ELR14817.1 - 0.062 12.2 0.1 0.09 11.7 0.1 1.2 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain Mg_chelatase PF01078.21 ELR14817.1 - 0.065 12.6 0.1 0.084 12.2 0.1 1.4 1 1 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_28 PF13521.6 ELR14817.1 - 0.073 13.3 0.1 0.11 12.8 0.1 1.3 1 0 0 1 1 1 0 AAA domain SRP54 PF00448.22 ELR14817.1 - 0.087 12.4 0.1 0.15 11.7 0.1 1.4 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain AAA_7 PF12775.7 ELR14817.1 - 0.094 12.2 0.0 0.14 11.6 0.0 1.2 1 0 0 1 1 1 0 P-loop containing dynein motor region cobW PF02492.19 ELR14817.1 - 0.12 12.0 0.1 0.21 11.2 0.1 1.4 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA_24 PF13479.6 ELR14817.1 - 0.12 12.1 0.0 0.39 10.4 0.0 1.7 2 0 0 2 2 2 0 AAA domain MMR_HSR1 PF01926.23 ELR14817.1 - 0.13 12.4 0.0 0.25 11.5 0.0 1.6 1 1 0 1 1 1 0 50S ribosome-binding GTPase MobB PF03205.14 ELR14817.1 - 0.16 11.9 0.0 0.42 10.5 0.0 1.7 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B Rad17 PF03215.15 ELR14817.1 - 0.17 11.8 0.0 0.37 10.7 0.0 1.5 1 0 0 1 1 1 0 Rad17 P-loop domain RuvB_N PF05496.12 ELR14817.1 - 0.18 11.5 0.2 0.74 9.5 0.1 2.0 2 0 0 2 2 2 0 Holliday junction DNA helicase RuvB P-loop domain zf-RING_11 PF17123.5 ELR14818.1 - 0.00065 19.4 0.1 0.0011 18.6 0.1 1.3 1 0 0 1 1 1 1 RING-like zinc finger zf-RING_2 PF13639.6 ELR14818.1 - 0.022 15.1 0.0 0.035 14.4 0.0 1.3 1 0 0 1 1 1 0 Ring finger domain TFIIA PF03153.13 ELR14818.1 - 5.4 6.9 5.9 6.7 6.6 5.9 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Methyltransf_11 PF08241.12 ELR14819.1 - 1.4e-09 38.5 0.0 2.9e-09 37.4 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ELR14819.1 - 5.8e-08 33.3 0.1 4.4e-07 30.5 0.1 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ELR14819.1 - 7.9e-05 22.5 0.0 9.8e-05 22.2 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 ELR14819.1 - 0.012 15.0 0.1 2.2 7.6 0.1 2.1 2 0 0 2 2 2 0 ubiE/COQ5 methyltransferase family zf_C2H2_10 PF18414.1 ELR14819.1 - 0.13 11.8 0.3 0.32 10.6 0.3 1.6 1 0 0 1 1 1 0 C2H2 type zinc-finger Methyltransf_12 PF08242.12 ELR14819.1 - 0.14 12.9 0.0 0.24 12.2 0.0 1.4 1 1 0 1 1 1 0 Methyltransferase domain DUF1442 PF07279.11 ELR14819.1 - 0.18 11.1 0.0 0.22 10.8 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1442) FA_hydroxylase PF04116.13 ELR14820.1 - 1.2e-29 103.3 10.8 1.2e-29 103.3 10.8 2.1 2 0 0 2 2 2 1 Fatty acid hydroxylase superfamily Yip1 PF04893.17 ELR14821.1 - 0.0051 16.6 1.0 0.0064 16.2 1.0 1.1 1 0 0 1 1 1 1 Yip1 domain DUF2254 PF10011.9 ELR14821.1 - 0.044 12.6 0.0 0.045 12.6 0.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2254) DUF347 PF03988.12 ELR14821.1 - 6.9 6.9 8.6 11 6.3 2.6 2.2 2 0 0 2 2 2 0 Repeat of Unknown Function (DUF347) GRAM PF02893.20 ELR14822.1 - 2.1e-13 50.1 0.0 3.2e-13 49.6 0.0 1.2 1 0 0 1 1 1 1 GRAM domain WH2 PF02205.20 ELR14823.1 - 4.4e-09 35.9 0.5 7.2e-09 35.2 0.5 1.4 1 0 0 1 1 1 1 WH2 motif Thymosin PF01290.20 ELR14823.1 - 0.082 12.7 0.0 0.18 11.5 0.0 1.5 1 0 0 1 1 1 0 Thymosin beta-4 family A_deaminase PF00962.22 ELR14824.1 - 1.7e-22 80.2 0.2 5.3e-13 49.0 0.0 2.8 2 1 0 2 2 2 2 Adenosine/AMP deaminase DUF4378 PF14309.6 ELR14824.1 - 0.091 13.1 0.0 0.17 12.2 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4378) zf-C3HC4_2 PF13923.6 ELR14825.1 - 4.9e-06 26.3 7.9 8.3e-06 25.5 7.9 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 ELR14825.1 - 1.9e-05 24.4 8.5 3.4e-05 23.6 8.5 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ELR14825.1 - 0.00024 21.0 7.0 0.00024 21.0 7.0 1.7 2 0 0 2 2 2 1 zinc-RING finger domain zf-RING_2 PF13639.6 ELR14825.1 - 0.0004 20.6 8.0 0.00076 19.8 8.0 1.5 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_3 PF13920.6 ELR14825.1 - 0.0027 17.5 11.8 0.0043 16.9 11.8 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 ELR14825.1 - 0.0036 17.6 4.9 0.007 16.6 4.9 1.5 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_UBOX PF13445.6 ELR14825.1 - 0.013 15.5 3.5 0.028 14.4 3.5 1.5 1 0 0 1 1 1 0 RING-type zinc-finger zf-RING_6 PF14835.6 ELR14825.1 - 0.019 14.8 2.9 0.035 14.0 2.9 1.4 1 0 0 1 1 1 0 zf-RING of BARD1-type protein zf-C3HC4_5 PF17121.5 ELR14825.1 - 0.062 13.2 6.3 0.22 11.4 6.2 2.0 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) PolC_DP2 PF03833.13 ELR14825.1 - 0.097 10.5 0.4 0.13 10.0 0.4 1.1 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 RAWUL PF16207.5 ELR14825.1 - 0.19 12.4 0.0 0.39 11.4 0.0 1.6 1 0 0 1 1 1 0 RAWUL domain RING finger- and WD40-associated ubiquitin-like zf-RING_4 PF14570.6 ELR14825.1 - 0.57 10.0 9.5 1 9.2 9.5 1.3 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-C3HC4_4 PF15227.6 ELR14825.1 - 0.64 10.2 6.9 1.6 9.0 6.9 1.6 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING Hydrolase_4 PF12146.8 ELR14826.1 - 2e-58 197.5 0.0 2.4e-58 197.2 0.0 1.1 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 ELR14826.1 - 5.6e-18 65.5 0.3 4.6e-12 46.1 0.1 2.1 1 1 1 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 ELR14826.1 - 6.9e-14 53.0 2.4 6.9e-14 53.0 2.4 1.4 2 0 0 2 2 2 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.21 ELR14826.1 - 3.8e-08 33.1 0.2 0.00019 21.0 0.0 2.3 2 0 0 2 2 2 2 Prolyl oligopeptidase family Esterase PF00756.20 ELR14826.1 - 5.5e-05 22.9 0.1 9.4e-05 22.2 0.0 1.6 2 1 0 2 2 2 1 Putative esterase LIDHydrolase PF10230.9 ELR14826.1 - 0.00019 21.1 0.0 0.00036 20.2 0.0 1.4 1 0 0 1 1 1 1 Lipid-droplet associated hydrolase Tannase PF07519.11 ELR14826.1 - 0.00053 19.0 0.0 0.0053 15.7 0.0 2.0 2 0 0 2 2 2 1 Tannase and feruloyl esterase Abhydrolase_3 PF07859.13 ELR14826.1 - 0.00094 19.1 0.0 0.0018 18.2 0.0 1.5 1 0 0 1 1 1 1 alpha/beta hydrolase fold UPF0227 PF05728.12 ELR14826.1 - 0.019 14.9 0.0 0.056 13.4 0.0 1.7 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0227) DLH PF01738.18 ELR14826.1 - 0.033 13.8 0.0 1.5 8.3 0.0 2.2 2 0 0 2 2 2 0 Dienelactone hydrolase family DUF2920 PF11144.8 ELR14826.1 - 0.034 13.3 0.0 0.13 11.4 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2920) Peptidase_S10 PF00450.22 ELR14826.1 - 0.041 13.3 0.0 1.2 8.5 0.0 2.0 2 0 0 2 2 2 0 Serine carboxypeptidase Chlorophyllase2 PF12740.7 ELR14826.1 - 0.18 10.7 0.0 0.28 10.1 0.0 1.3 1 0 0 1 1 1 0 Chlorophyllase enzyme GTP_EFTU PF00009.27 ELR14827.1 - 1.4e-30 106.3 0.0 1.8e-30 105.9 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain F-box-like PF12937.7 ELR14827.1 - 2.2e-07 30.7 0.4 4.6e-07 29.6 0.4 1.6 1 0 0 1 1 1 1 F-box-like MMR_HSR1 PF01926.23 ELR14827.1 - 3.5e-05 23.9 0.1 0.00015 21.8 0.1 1.9 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU_D3 PF03143.17 ELR14827.1 - 0.00077 19.7 0.0 0.0015 18.8 0.0 1.5 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain FeoB_N PF02421.18 ELR14827.1 - 0.0044 16.6 0.1 0.19 11.3 0.0 2.3 2 0 0 2 2 2 1 Ferrous iron transport protein B F-box PF00646.33 ELR14827.1 - 0.0092 15.8 0.1 0.021 14.7 0.1 1.6 1 0 0 1 1 1 1 F-box domain F-box_5 PF18511.1 ELR14827.1 - 0.071 12.7 0.8 0.23 11.1 0.8 1.9 1 0 0 1 1 1 0 F-box SRPRB PF09439.10 ELR14827.1 - 0.098 12.1 0.0 5.1 6.5 0.0 2.2 2 0 0 2 2 2 0 Signal recognition particle receptor beta subunit GTP_EFTU PF00009.27 ELR14829.1 - 2e-28 99.3 0.0 1.4e-27 96.5 0.0 2.0 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain TatD_DNase PF01026.21 ELR14829.1 - 2.2e-07 30.5 0.1 3.6e-07 29.8 0.1 1.4 1 0 0 1 1 1 1 TatD related DNase F-box-like PF12937.7 ELR14829.1 - 9.8e-06 25.4 0.7 2.2e-05 24.3 0.1 1.9 2 0 0 2 2 2 1 F-box-like MMR_HSR1 PF01926.23 ELR14829.1 - 4.6e-05 23.5 0.1 0.00048 20.2 0.0 2.5 2 1 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 ELR14829.1 - 0.0052 16.3 0.9 1.1 8.7 0.0 3.4 4 0 0 4 4 4 1 Ferrous iron transport protein B F-box PF00646.33 ELR14829.1 - 0.024 14.5 0.0 0.076 12.9 0.0 1.9 1 1 0 1 1 1 0 F-box domain SRPRB PF09439.10 ELR14829.1 - 0.18 11.3 0.0 6.8 6.1 0.0 2.2 2 0 0 2 2 2 0 Signal recognition particle receptor beta subunit TatD_DNase PF01026.21 ELR14830.1 - 5e-32 111.3 0.0 6.2e-32 111.0 0.0 1.1 1 0 0 1 1 1 1 TatD related DNase Tail_P2_I PF09684.10 ELR14830.1 - 0.0059 16.5 0.0 0.012 15.5 0.0 1.5 1 0 0 1 1 1 1 Phage tail protein (Tail_P2_I) A_deaminase PF00962.22 ELR14831.1 - 8.2e-31 107.5 0.0 9.1e-31 107.4 0.0 1.0 1 0 0 1 1 1 1 Adenosine/AMP deaminase SH3_9 PF14604.6 ELR14832.1 - 1.4e-21 76.0 5.8 2.6e-10 40.0 0.8 3.7 4 0 0 4 4 4 3 Variant SH3 domain SH3_2 PF07653.17 ELR14832.1 - 1.1e-20 73.0 0.1 5.1e-07 29.3 0.0 3.5 3 0 0 3 3 3 3 Variant SH3 domain SH3_1 PF00018.28 ELR14832.1 - 1e-17 63.4 3.2 6.8e-08 32.0 0.2 3.7 3 0 0 3 3 3 3 SH3 domain SH3_16 PF18348.1 ELR14832.1 - 0.19 11.6 2.8 2.5 8.0 0.3 3.2 3 0 0 3 3 3 0 Bacterial dipeptidyl-peptidase Sh3 domain Laminin_G_3 PF13385.6 ELR14833.1 - 1.1e-11 45.1 0.3 4.7e-11 43.1 0.0 2.2 2 1 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Cadherin_3 PF16184.5 ELR14833.1 - 0.19 11.7 0.0 0.5 10.4 0.0 1.7 2 0 0 2 2 2 0 Cadherin-like Ank_4 PF13637.6 ELR14834.1 - 2.8e-59 196.8 29.3 2.2e-13 50.4 0.1 6.9 1 1 7 8 8 8 8 Ankyrin repeats (many copies) Ank_2 PF12796.7 ELR14834.1 - 7e-52 174.0 9.8 7.9e-13 48.8 0.1 4.6 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank PF00023.30 ELR14834.1 - 2.5e-41 138.3 17.6 4.7e-07 30.0 0.1 8.5 8 0 0 8 8 8 8 Ankyrin repeat RabGAP-TBC PF00566.18 ELR14834.1 - 1.4e-39 136.0 0.7 6.3e-38 130.6 0.7 2.3 1 1 0 1 1 1 1 Rab-GTPase-TBC domain Ank_5 PF13857.6 ELR14834.1 - 1.4e-37 127.2 20.8 2.1e-10 40.6 0.2 7.7 1 1 7 8 8 8 8 Ankyrin repeats (many copies) Ank_3 PF13606.6 ELR14834.1 - 4.8e-31 103.3 9.7 0.00018 21.6 0.0 9.3 10 0 0 10 10 10 7 Ankyrin repeat PilX PF13681.6 ELR14836.1 - 4.3 7.8 5.8 1.6 9.2 2.2 2.2 2 1 0 2 2 2 0 Type IV pilus assembly protein PilX C-term SET PF00856.28 ELR14837.1 - 8.6e-10 39.3 0.0 1.5e-09 38.5 0.0 1.4 1 1 0 1 1 1 1 SET domain PRP3 PF08572.10 ELR14839.1 - 0.03 14.1 6.3 0.06 13.1 6.3 1.5 1 0 0 1 1 1 0 pre-mRNA processing factor 3 (PRP3) DAG_kinase_N PF14513.6 ELR14839.1 - 0.082 13.1 0.2 0.082 13.1 0.2 2.1 2 0 0 2 2 2 0 Diacylglycerol kinase N-terminus DUF1525 PF07511.11 ELR14839.1 - 0.18 12.0 4.2 0.35 11.0 4.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1525) Rad51 PF08423.11 ELR14840.1 - 9.8e-06 25.0 0.0 0.14 11.4 0.0 2.2 2 0 0 2 2 2 2 Rad51 AAA_25 PF13481.6 ELR14840.1 - 0.00038 20.1 1.4 0.56 9.7 0.0 2.6 2 1 0 2 2 2 2 AAA domain RecA PF00154.21 ELR14840.1 - 0.0075 15.8 1.8 0.0088 15.5 0.2 1.8 2 0 0 2 2 2 1 recA bacterial DNA recombination protein AAA_24 PF13479.6 ELR14840.1 - 0.0083 15.9 0.0 0.41 10.4 0.0 2.3 2 0 0 2 2 2 1 AAA domain ATPase PF06745.13 ELR14840.1 - 0.048 13.0 0.7 2.8 7.2 0.2 2.4 2 0 0 2 2 2 0 KaiC Adeno_PIX PF03955.14 ELR14840.1 - 0.088 13.0 1.5 0.28 11.3 1.5 1.8 1 0 0 1 1 1 0 Adenovirus hexon-associated protein (IX) DUF3446 PF11928.8 ELR14840.1 - 0.69 10.3 10.4 0.42 11.0 2.2 3.2 3 0 0 3 3 3 0 Early growth response N-terminal domain RskA PF10099.9 ELR14840.1 - 1 9.6 6.8 0.38 11.0 0.1 2.4 2 0 0 2 2 2 0 Anti-sigma-K factor rskA FYDLN_acid PF09538.10 ELR14840.1 - 8.2 7.2 7.9 2 9.1 2.9 2.1 2 0 0 2 2 2 0 Protein of unknown function (FYDLN_acid) UQ_con PF00179.26 ELR14841.1 - 2.8e-25 88.6 0.0 6.2e-25 87.5 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme ubiquitin PF00240.23 ELR14841.1 - 9.2e-09 34.9 0.0 3.1e-08 33.3 0.0 1.9 1 0 0 1 1 1 1 Ubiquitin family Ubiquitin_2 PF14560.6 ELR14841.1 - 0.027 14.9 0.1 0.22 12.0 0.1 2.5 2 1 0 2 2 2 0 Ubiquitin-like domain UEV PF05743.13 ELR14841.1 - 0.035 14.0 0.1 0.11 12.3 0.1 1.8 1 0 0 1 1 1 0 UEV domain PPL4 PF18188.1 ELR14841.1 - 0.052 13.5 0.1 0.11 12.4 0.1 1.5 1 0 0 1 1 1 0 Prim-pol 4 Rad60-SLD PF11976.8 ELR14841.1 - 0.42 10.5 0.0 0.42 10.5 0.0 2.3 3 0 0 3 3 3 0 Ubiquitin-2 like Rad60 SUMO-like TrkH PF02386.16 ELR14842.1 - 2.5e-68 230.8 22.4 8.8e-68 229.0 9.8 2.1 1 1 1 2 2 2 2 Cation transport protein Integrin_b_cyt PF08725.11 ELR14842.1 - 0.012 15.2 0.0 0.025 14.2 0.0 1.5 1 0 0 1 1 1 0 Integrin beta cytoplasmic domain HMGL-like PF00682.19 ELR14843.1 - 1.1e-34 120.2 0.0 1.8e-34 119.5 0.0 1.2 1 0 0 1 1 1 1 HMGL-like TPR_14 PF13428.6 ELR14844.1 - 0.11 13.4 6.4 7.6 7.6 0.0 4.4 4 1 1 5 5 5 0 Tetratricopeptide repeat TPR_2 PF07719.17 ELR14844.1 - 0.21 11.8 7.2 0.4 10.9 1.8 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat FRB_dom PF08771.11 ELR14844.1 - 0.27 11.6 4.3 0.16 12.4 0.6 2.5 2 1 0 2 2 2 0 FKBP12-rapamycin binding domain BTB PF00651.31 ELR14845.1 - 9.4e-12 45.1 0.0 2.9e-11 43.6 0.0 1.8 1 0 0 1 1 1 1 BTB/POZ domain FA_hydroxylase PF04116.13 ELR14846.1 - 2.7e-09 37.5 4.4 3e-09 37.3 4.4 1.0 1 0 0 1 1 1 1 Fatty acid hydroxylase superfamily Lectin_N PF03954.14 ELR14847.1 - 0.0018 18.0 1.9 0.003 17.3 0.6 1.8 2 0 0 2 2 2 1 Hepatic lectin, N-terminal domain TSC22 PF01166.18 ELR14847.1 - 0.0029 17.9 2.6 0.47 10.8 0.1 3.4 2 1 1 3 3 3 1 TSC-22/dip/bun family DUF725 PF05267.12 ELR14847.1 - 0.061 13.3 2.3 0.12 12.3 2.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF725) KfrB PF18790.1 ELR14847.1 - 0.085 13.1 9.6 2.2 8.6 1.1 3.1 2 1 1 3 3 3 0 KfrB protein zf-C4H2 PF10146.9 ELR14847.1 - 0.3 11.3 4.8 0.39 11.0 4.8 1.2 1 0 0 1 1 1 0 Zinc finger-containing protein Spc7 PF08317.11 ELR14847.1 - 0.31 9.9 7.1 0.36 9.7 7.1 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein DivIC PF04977.15 ELR14847.1 - 0.44 10.3 13.0 0.9 9.4 5.1 3.1 2 1 1 3 3 3 0 Septum formation initiator DUF4407 PF14362.6 ELR14847.1 - 0.62 9.4 16.0 0.91 8.8 16.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) ERM PF00769.19 ELR14847.1 - 0.62 9.8 17.5 0.85 9.4 17.5 1.2 1 0 0 1 1 1 0 Ezrin/radixin/moesin family TMF_TATA_bd PF12325.8 ELR14847.1 - 0.65 10.2 7.3 8.8 6.6 6.6 2.6 1 1 0 1 1 1 0 TATA element modulatory factor 1 TATA binding HAUS6_N PF14661.6 ELR14847.1 - 1.1 8.7 7.0 1.4 8.5 7.0 1.1 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus Syntaxin PF00804.25 ELR14847.1 - 1.8 8.2 8.0 6.3 6.4 6.9 1.9 1 1 1 2 2 2 0 Syntaxin Usp PF00582.26 ELR14847.1 - 2.4 8.7 14.9 3.2 8.2 14.9 1.2 1 0 0 1 1 1 0 Universal stress protein family V_ATPase_I PF01496.19 ELR14847.1 - 2.8 5.7 4.4 3.2 5.6 4.4 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family ZapB PF06005.12 ELR14847.1 - 7.9 7.0 9.8 3.8e+02 1.6 9.8 2.6 1 1 0 1 1 1 0 Cell division protein ZapB APG6_N PF17675.1 ELR14847.1 - 8.1 7.0 18.3 2.4 8.7 13.2 2.2 1 1 1 2 2 2 0 Apg6 coiled-coil region Uso1_p115_C PF04871.13 ELR14847.1 - 9.9 6.6 20.1 5 7.5 15.5 2.0 1 1 1 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region Glyco_transf_25 PF01755.17 ELR14848.1 - 0.064 13.1 0.0 0.14 12.0 0.0 1.6 1 1 0 1 1 1 0 Glycosyltransferase family 25 (LPS biosynthesis protein) DUF563 PF04577.14 ELR14849.1 - 1.3e-19 71.1 0.1 1.7e-19 70.8 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF563) LtuA PF17446.2 ELR14849.1 - 0.25 11.8 1.5 0.82 10.1 0.1 2.2 2 0 0 2 2 2 0 Late transcription unit A BTB PF00651.31 ELR14850.1 - 9e-14 51.6 0.0 1.3e-12 47.9 0.0 2.5 2 0 0 2 2 2 1 BTB/POZ domain DUF4685 PF15737.5 ELR14850.1 - 0.025 15.0 0.8 2.8 8.4 2.0 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4685) DUF3446 PF11928.8 ELR14850.1 - 0.31 11.4 15.7 2 8.8 9.5 2.7 2 0 0 2 2 2 0 Early growth response N-terminal domain DUF4667 PF15700.5 ELR14850.1 - 0.6 10.2 4.4 1 9.4 4.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4667) SR-25 PF10500.9 ELR14850.1 - 0.81 9.3 10.3 1.5 8.4 10.3 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein IMUP PF15761.5 ELR14850.1 - 5.1 7.8 13.8 3.4 8.4 11.1 2.1 2 0 0 2 2 2 0 Immortalisation up-regulated protein FA_hydroxylase PF04116.13 ELR14851.1 - 1.3e-24 87.1 15.2 1.7e-24 86.7 15.2 1.2 1 0 0 1 1 1 1 Fatty acid hydroxylase superfamily Carb_anhydrase PF00194.21 ELR14852.1 - 6.6e-46 156.9 0.1 1e-45 156.3 0.1 1.3 1 1 0 1 1 1 1 Eukaryotic-type carbonic anhydrase RhoGEF PF00621.20 ELR14853.1 - 1.6e-50 171.9 0.1 1.6e-50 171.9 0.1 2.1 2 0 0 2 2 2 1 RhoGEF domain VHP PF02209.19 ELR14853.1 - 2.6e-11 43.4 3.0 2.6e-11 43.4 3.0 2.7 2 0 0 2 2 2 1 Villin headpiece domain CH PF00307.31 ELR14853.1 - 1.1e-10 41.7 0.1 5.5e-10 39.4 0.0 2.3 2 0 0 2 2 2 1 Calponin homology (CH) domain IQ PF00612.27 ELR14853.1 - 0.0042 16.8 0.4 0.011 15.4 0.4 1.8 1 0 0 1 1 1 1 IQ calmodulin-binding motif IQ_SEC7_PH PF16453.5 ELR14853.1 - 0.0098 15.9 0.4 0.036 14.0 0.1 2.1 2 0 0 2 2 2 1 PH domain CLN3 PF02487.17 ELR14854.1 - 2e-121 405.8 5.2 2.6e-121 405.5 5.2 1.1 1 0 0 1 1 1 1 CLN3 protein WH2 PF02205.20 ELR14855.1 - 2.3e-06 27.2 2.1 0.95 9.4 0.2 4.8 4 1 0 4 4 4 2 WH2 motif CsbD PF05532.12 ELR14855.1 - 9.5e-05 22.2 1.6 9.5e-05 22.2 1.6 2.5 2 1 0 2 2 2 1 CsbD-like LEA_4 PF02987.16 ELR14855.1 - 0.036 14.1 1.7 0.12 12.5 1.7 1.8 1 0 0 1 1 1 0 Late embryogenesis abundant protein F-box-like PF12937.7 ELR14856.1 - 0.032 14.1 0.2 0.032 14.1 0.2 2.1 3 0 0 3 3 3 0 F-box-like CPSF_A PF03178.15 ELR14857.1 - 2.6e-59 201.2 0.0 7.4e-59 199.7 0.0 1.8 1 1 0 1 1 1 1 CPSF A subunit region MMS1_N PF10433.9 ELR14857.1 - 5.4e-44 150.6 0.0 8.8e-44 149.9 0.0 1.4 1 0 0 1 1 1 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term Sigma70_r4 PF04545.16 ELR14857.1 - 0.069 12.7 0.0 0.19 11.3 0.0 1.7 1 0 0 1 1 1 0 Sigma-70, region 4 CDC45 PF02724.14 ELR14857.1 - 8.7 4.5 9.2 9.5 4.4 0.1 2.3 2 0 0 2 2 2 0 CDC45-like protein DUF4637 PF15470.6 ELR14858.1 - 0.14 11.9 3.3 0.33 10.7 3.3 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) SDA1 PF05285.12 ELR14858.1 - 0.31 10.4 10.6 0.45 9.9 10.6 1.2 1 0 0 1 1 1 0 SDA1 CsbD PF05532.12 ELR14859.1 - 1e-06 28.5 2.8 1e-06 28.5 2.8 2.6 2 0 0 2 2 2 1 CsbD-like Med4 PF10018.9 ELR14859.1 - 0.015 15.0 0.3 0.015 15.0 0.3 2.3 2 1 0 2 2 2 0 Vitamin-D-receptor interacting Mediator subunit 4 WASH_WAHD PF11945.8 ELR14860.1 - 5.1e-55 187.1 0.0 7.4e-55 186.5 0.0 1.2 1 0 0 1 1 1 1 WAHD domain of WASH complex WH2 PF02205.20 ELR14860.1 - 1.5e-05 24.7 0.6 2.7e-05 23.8 0.6 1.4 1 0 0 1 1 1 1 WH2 motif Glyco_hydro_43 PF04616.14 ELR14861.1 - 7.1e-41 140.4 0.3 1.4e-40 139.4 0.3 1.5 1 1 0 1 1 1 1 Glycosyl hydrolases family 43 Glyco_hydro_32N PF00251.20 ELR14861.1 - 0.043 13.4 0.8 0.74 9.3 0.0 2.2 2 0 0 2 2 2 0 Glycosyl hydrolases family 32 N-terminal domain TLD PF07534.16 ELR14862.1 - 3.7e-09 36.9 0.0 7.2e-09 36.0 0.0 1.5 1 0 0 1 1 1 1 TLD F-box-like PF12937.7 ELR14862.1 - 4.2e-09 36.1 0.0 7.9e-09 35.3 0.0 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ELR14862.1 - 5.5e-07 29.3 0.4 1.7e-06 27.8 0.1 2.0 2 0 0 2 2 2 1 F-box domain zf-RanBP PF00641.18 ELR14862.1 - 0.0036 16.6 3.5 0.0071 15.6 3.5 1.5 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others Zf_RING PF16744.5 ELR14862.1 - 0.19 11.9 2.2 0.2 11.8 0.4 2.0 1 1 1 2 2 2 0 KIAA1045 RING finger CTD_bind PF04818.13 ELR14863.1 - 1.3e-06 29.1 0.1 4.4e-06 27.4 0.0 2.0 2 0 0 2 2 2 1 RNA polymerase II-binding domain. zf_UBZ PF18439.1 ELR14863.1 - 0.00011 21.7 2.0 0.00012 21.6 0.2 1.9 2 0 0 2 2 2 1 Ubiquitin-Binding Zinc Finger zf-C2H2 PF00096.26 ELR14863.1 - 0.018 15.5 3.2 0.087 13.3 0.2 2.5 2 0 0 2 2 2 0 Zinc finger, C2H2 type Sporozoite_P67 PF05642.11 ELR14863.1 - 0.043 11.9 0.0 0.13 10.3 0.0 1.7 1 1 0 1 1 1 0 Sporozoite P67 surface antigen DUF2500 PF10694.9 ELR14863.1 - 0.11 13.0 0.4 0.23 12.0 0.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2500) zf-C2H2_4 PF13894.6 ELR14863.1 - 0.22 12.4 3.0 1 10.4 0.2 2.6 2 0 0 2 2 2 0 C2H2-type zinc finger Actin_micro PF17003.5 ELR14863.1 - 0.44 9.7 1.8 6.7 5.8 0.3 2.2 2 0 0 2 2 2 0 Putative actin-like family MPM1 PF17234.2 ELR14863.1 - 2.4 8.4 9.2 17 5.6 0.1 2.2 2 0 0 2 2 2 0 Mitochondrial peculiar membrane protein 1 Roughex PF06020.11 ELR14863.1 - 3.5 6.6 5.4 6.5 5.7 5.4 1.3 1 0 0 1 1 1 0 Drosophila roughex protein Spt20 PF12090.8 ELR14863.1 - 4.6 6.8 11.5 10 5.6 11.5 1.5 1 0 0 1 1 1 0 Spt20 family TFIIA PF03153.13 ELR14863.1 - 5 7.0 19.8 4.2 7.3 7.7 2.3 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Lyase_1 PF00206.20 ELR14864.1 - 9.3e-121 403.0 0.0 1.2e-120 402.6 0.0 1.2 1 0 0 1 1 1 1 Lyase FumaraseC_C PF10415.9 ELR14864.1 - 1.9e-26 92.3 0.0 6.3e-26 90.6 0.0 2.0 1 0 0 1 1 1 1 Fumarase C C-terminus DHHA1 PF02272.19 ELR14865.1 - 0.085 13.3 0.4 0.43 11.0 0.0 2.3 3 0 0 3 3 3 0 DHHA1 domain Cyclase PF04199.13 ELR14866.1 - 4e-22 78.9 0.0 5.1e-22 78.6 0.0 1.1 1 0 0 1 1 1 1 Putative cyclase RhoGAP PF00620.27 ELR14867.1 - 4e-22 78.7 0.0 9.4e-22 77.5 0.0 1.5 1 0 0 1 1 1 1 RhoGAP domain SAPS PF04499.15 ELR14867.1 - 0.099 11.4 7.5 0.15 10.9 7.5 1.4 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein AAA_11 PF13086.6 ELR14867.1 - 0.85 9.3 14.7 1.7 8.4 14.7 1.5 1 0 0 1 1 1 0 AAA domain VIR_N PF15912.5 ELR14867.1 - 1.1 8.9 19.2 1.9 8.0 19.2 1.3 1 0 0 1 1 1 0 Virilizer, N-terminal DUF4778 PF16008.5 ELR14867.1 - 4.8 7.2 18.5 0.87 9.6 14.6 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4778) Smg8_Smg9 PF10220.9 ELR14867.1 - 5.2 5.3 15.2 7.6 4.7 15.2 1.2 1 0 0 1 1 1 0 Smg8_Smg9 Zip PF02535.22 ELR14867.1 - 8.5 5.5 13.8 0.21 10.8 7.2 1.7 2 0 0 2 2 2 0 ZIP Zinc transporter Cyclase PF04199.13 ELR14868.1 - 7.7e-20 71.5 0.0 1.1e-19 71.0 0.0 1.2 1 0 0 1 1 1 1 Putative cyclase NAD_Gly3P_dh_C PF07479.14 ELR14869.1 - 3e-43 147.5 0.2 9.3e-43 145.9 0.3 1.7 2 0 0 2 2 2 1 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus NAD_Gly3P_dh_N PF01210.23 ELR14869.1 - 3.7e-30 105.0 2.0 1.1e-28 100.2 2.0 2.8 1 1 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus DUF3994 PF13159.6 ELR14869.1 - 0.081 13.5 0.0 0.38 11.3 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF3994) AMP-binding PF00501.28 ELR14870.1 - 4.3e-77 259.5 0.0 8.1e-50 169.6 0.0 2.1 2 0 0 2 2 2 2 AMP-binding enzyme AMP-binding_C PF13193.6 ELR14870.1 - 0.0065 17.4 0.6 0.11 13.4 0.1 3.1 2 1 0 3 3 3 1 AMP-binding enzyme C-terminal domain Adeno_knob PF00541.17 ELR14870.1 - 0.013 15.3 0.0 0.028 14.2 0.0 1.5 1 0 0 1 1 1 0 Adenoviral fibre protein (knob domain) CCDC24 PF15669.5 ELR14870.1 - 0.15 12.0 9.5 0.21 11.4 5.3 2.4 2 1 0 2 2 2 0 Coiled-coil domain-containing protein 24 family 14-3-3 PF00244.20 ELR14871.1 - 8.9e-105 349.1 0.3 1e-104 348.9 0.3 1.0 1 0 0 1 1 1 1 14-3-3 protein Tho2 PF11262.8 ELR14872.1 - 2.9e-80 269.7 0.8 2.4e-63 214.1 0.5 2.3 1 1 1 2 2 2 2 Transcription factor/nuclear export subunit protein 2 THOC2_N PF16134.5 ELR14872.1 - 5.8e-68 230.0 12.3 6.6e-29 101.0 0.0 4.8 3 1 2 5 5 5 3 THO complex subunit 2 N-terminus Thoc2 PF11732.8 ELR14872.1 - 1.6e-29 101.8 0.1 3.7e-29 100.6 0.1 1.7 1 0 0 1 1 1 1 Transcription- and export-related complex subunit FlxA PF14282.6 ELR14872.1 - 0.0066 16.4 0.2 0.0066 16.4 0.2 3.7 5 0 0 5 5 5 1 FlxA-like protein Phage_GP20 PF06810.11 ELR14872.1 - 0.14 12.0 3.5 0.32 10.8 3.5 1.5 1 0 0 1 1 1 0 Phage minor structural protein GP20 Podoplanin PF05808.11 ELR14872.1 - 0.19 11.8 0.0 0.19 11.8 0.0 4.3 4 0 0 4 4 4 0 Podoplanin Prefoldin_2 PF01920.20 ELR14872.1 - 1.7 8.7 9.0 2.4 8.1 0.1 3.2 2 1 1 3 3 3 0 Prefoldin subunit OmpH PF03938.14 ELR14872.1 - 2.7 8.3 10.1 0.06 13.7 0.8 2.5 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) FapA PF03961.13 ELR14872.1 - 3 6.4 4.3 0.56 8.7 0.2 1.7 2 0 0 2 2 2 0 Flagellar Assembly Protein A DUF1664 PF07889.12 ELR14873.1 - 2.4e-06 27.6 0.4 3.6e-06 27.0 0.4 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1664) HALZ PF02183.18 ELR14873.1 - 0.0031 17.7 0.2 0.28 11.4 0.0 3.1 2 1 1 3 3 3 1 Homeobox associated leucine zipper Lectin_N PF03954.14 ELR14873.1 - 0.0051 16.6 0.7 0.0075 16.0 0.7 1.2 1 0 0 1 1 1 1 Hepatic lectin, N-terminal domain Atg14 PF10186.9 ELR14873.1 - 0.018 14.1 0.5 0.022 13.9 0.5 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF4201 PF13870.6 ELR14873.1 - 0.025 14.3 0.2 0.036 13.8 0.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4201) CENP-F_leu_zip PF10473.9 ELR14873.1 - 0.046 13.7 0.1 0.082 12.9 0.1 1.4 1 0 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 ADIP PF11559.8 ELR14873.1 - 0.049 13.7 0.7 0.08 13.0 0.7 1.3 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding Cluap1 PF10234.9 ELR14873.1 - 0.051 13.0 0.4 0.059 12.8 0.4 1.1 1 0 0 1 1 1 0 Clusterin-associated protein-1 LPP PF04728.13 ELR14873.1 - 0.059 13.8 4.7 0.13 12.7 3.6 2.0 1 1 1 2 2 2 0 Lipoprotein leucine-zipper Not3 PF04065.15 ELR14873.1 - 0.099 12.1 0.0 0.13 11.7 0.0 1.1 1 0 0 1 1 1 0 Not1 N-terminal domain, CCR4-Not complex component KxDL PF10241.9 ELR14873.1 - 0.11 12.8 0.4 0.16 12.3 0.4 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein JIP_LZII PF16471.5 ELR14873.1 - 0.12 12.5 0.8 0.22 11.7 0.2 1.8 2 0 0 2 2 2 0 JNK-interacting protein leucine zipper II YecM PF06185.12 ELR14873.1 - 0.17 11.6 0.1 0.24 11.1 0.1 1.2 1 0 0 1 1 1 0 YecM protein DivIC PF04977.15 ELR14873.1 - 0.43 10.4 4.7 1.9 8.3 0.6 2.5 2 1 1 3 3 3 0 Septum formation initiator NPV_P10 PF05531.12 ELR14873.1 - 0.48 10.9 3.2 1.2 9.7 3.2 1.7 1 1 0 1 1 1 0 Nucleopolyhedrovirus P10 protein Alanine_zipper PF11839.8 ELR14873.1 - 0.77 10.2 12.6 1.6 9.1 12.6 1.5 1 0 0 1 1 1 0 Alanine-zipper, major outer membrane lipoprotein Rtf2 PF04641.12 ELR14874.1 - 2.5e-66 223.8 7.0 2.5e-66 223.8 7.0 2.0 1 1 1 2 2 2 1 Rtf2 RING-finger zf-NOSIP PF15906.5 ELR14874.1 - 0.017 15.3 0.0 0.049 13.8 0.0 1.8 1 0 0 1 1 1 0 Zinc-finger of nitric oxide synthase-interacting protein TRAF6_Z2 PF18048.1 ELR14874.1 - 0.32 11.1 2.2 11 6.3 0.2 2.5 2 0 0 2 2 2 0 TNF receptor-associated factor 6 zinc finger 2 DAG_kinase_N PF14513.6 ELR14874.1 - 0.49 10.6 4.2 0.96 9.6 4.2 1.5 1 0 0 1 1 1 0 Diacylglycerol kinase N-terminus API5 PF05918.11 ELR14874.1 - 1 8.1 7.8 1.5 7.5 7.8 1.3 1 0 0 1 1 1 0 Apoptosis inhibitory protein 5 (API5) DUF3807 PF12720.7 ELR14874.1 - 1.5 9.0 16.6 2.6 8.3 16.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) CDC45 PF02724.14 ELR14874.1 - 2.7 6.2 13.6 3.6 5.8 13.6 1.1 1 0 0 1 1 1 0 CDC45-like protein Zip PF02535.22 ELR14874.1 - 3.2 6.9 8.0 4.2 6.5 8.0 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter XRCC4 PF06632.12 ELR14874.1 - 7 5.4 14.7 9.9 4.9 14.7 1.1 1 0 0 1 1 1 0 DNA double-strand break repair and V(D)J recombination protein XRCC4 RR_TM4-6 PF06459.12 ELR14874.1 - 7.3 6.3 13.2 11 5.7 13.2 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 BAF1_ABF1 PF04684.13 ELR14874.1 - 9.1 5.2 15.6 12 4.8 15.6 1.1 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor NUDIX PF00293.28 ELR14875.1 - 8.2e-14 51.8 0.0 1.6e-13 50.8 0.0 1.5 1 0 0 1 1 1 1 NUDIX domain MTHFR PF02219.17 ELR14876.1 - 0.0012 18.2 0.0 0.0019 17.6 0.0 1.4 1 0 0 1 1 1 1 Methylenetetrahydrofolate reductase DUF5363 PF17320.2 ELR14876.1 - 0.088 12.7 0.4 0.8 9.6 0.0 2.5 2 0 0 2 2 2 0 Family of unknown function (DUF5363) DUF2533 PF10752.9 ELR14876.1 - 0.11 13.0 0.3 16 6.0 0.1 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF2533) Sel1 PF08238.12 ELR14877.1 - 4.5e-48 160.6 90.6 2.6e-09 37.4 1.9 12.1 11 2 1 12 12 12 10 Sel1 repeat HHA PF05321.11 ELR14877.1 - 0.013 15.8 1.5 0.17 12.2 0.0 3.6 2 1 1 3 3 3 0 Haemolysin expression modulating protein DUF977 PF06163.11 ELR14877.1 - 0.1 12.6 5.2 0.36 10.8 0.1 3.5 3 1 2 5 5 5 0 Bacterial protein of unknown function (DUF977) TrbI PF03743.14 ELR14877.1 - 0.15 11.9 0.8 0.42 10.4 0.8 1.7 1 0 0 1 1 1 0 Bacterial conjugation TrbI-like protein TPR_8 PF13181.6 ELR14877.1 - 3.7 8.0 9.1 25 5.4 0.3 6.2 8 1 0 8 8 8 0 Tetratricopeptide repeat Pkinase PF00069.25 ELR14878.1 - 1.6e-65 221.1 0.0 2.4e-65 220.5 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR14878.1 - 2.4e-31 109.0 0.0 8.1e-31 107.2 0.0 1.7 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ELR14878.1 - 2.3e-08 33.7 0.1 7.7e-07 28.7 0.0 2.1 1 1 1 2 2 2 1 Kinase-like FTA2 PF13095.6 ELR14878.1 - 0.001 18.7 0.3 1.2 8.7 0.2 2.3 2 0 0 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 Haspin_kinase PF12330.8 ELR14878.1 - 0.002 17.2 0.1 0.068 12.1 0.1 2.3 1 1 0 1 1 1 1 Haspin like kinase domain Pkinase_C PF00433.24 ELR14878.1 - 0.0026 18.4 1.3 0.006 17.3 1.3 1.7 1 0 0 1 1 1 1 Protein kinase C terminal domain Kdo PF06293.14 ELR14878.1 - 0.045 13.1 0.0 0.084 12.2 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 ELR14878.1 - 0.15 11.9 0.0 0.26 11.2 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family AAA PF00004.29 ELR14879.1 - 3.9e-40 137.3 0.0 6.8e-40 136.6 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 ELR14879.1 - 1.9e-12 46.8 0.0 4.7e-12 45.5 0.0 1.7 1 0 0 1 1 1 1 AAA+ lid domain AAA_5 PF07728.14 ELR14879.1 - 2.5e-06 27.5 0.0 7.4e-06 26.0 0.0 1.8 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 ELR14879.1 - 8.4e-06 26.1 0.3 0.0016 18.7 0.2 3.2 2 1 0 2 2 2 1 AAA domain AAA_2 PF07724.14 ELR14879.1 - 1.1e-05 25.6 0.0 2.8e-05 24.3 0.0 1.7 2 0 0 2 2 1 1 AAA domain (Cdc48 subfamily) RuvB_N PF05496.12 ELR14879.1 - 3.6e-05 23.6 0.0 6.9e-05 22.6 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain TniB PF05621.11 ELR14879.1 - 0.00081 18.9 0.0 0.42 10.0 0.0 2.5 1 1 0 2 2 2 2 Bacterial TniB protein AAA_25 PF13481.6 ELR14879.1 - 0.0014 18.3 0.1 0.73 9.4 0.0 2.7 2 0 0 2 2 2 1 AAA domain Vps4_C PF09336.10 ELR14879.1 - 0.0017 18.3 0.0 0.0055 16.7 0.0 1.9 1 0 0 1 1 1 1 Vps4 C terminal oligomerisation domain TIP49 PF06068.13 ELR14879.1 - 0.0022 17.2 0.0 0.0039 16.5 0.0 1.3 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_14 PF13173.6 ELR14879.1 - 0.0031 17.6 0.0 0.0068 16.4 0.0 1.6 1 0 0 1 1 1 1 AAA domain Mg_chelatase PF01078.21 ELR14879.1 - 0.0033 16.8 0.1 0.007 15.8 0.1 1.5 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_16 PF13191.6 ELR14879.1 - 0.0035 17.7 0.1 0.27 11.6 0.0 2.7 1 1 1 2 2 2 1 AAA ATPase domain IstB_IS21 PF01695.17 ELR14879.1 - 0.005 16.6 0.0 0.01 15.6 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein Fur_reg_FbpA PF13076.6 ELR14879.1 - 0.01 15.5 0.0 0.022 14.4 0.0 1.5 1 0 0 1 1 1 0 Fur-regulated basic protein A DUF815 PF05673.13 ELR14879.1 - 0.024 13.8 0.0 0.063 12.4 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF815) AAA_24 PF13479.6 ELR14879.1 - 0.029 14.1 0.0 0.058 13.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 ELR14879.1 - 0.039 14.3 0.0 0.095 13.1 0.0 1.7 1 0 0 1 1 1 0 RNA helicase Guanylate_kin PF00625.21 ELR14879.1 - 0.053 13.2 0.0 0.16 11.7 0.0 1.8 1 0 0 1 1 1 0 Guanylate kinase AAA_33 PF13671.6 ELR14879.1 - 0.055 13.6 0.1 0.13 12.4 0.0 1.8 2 0 0 2 2 1 0 AAA domain NACHT PF05729.12 ELR14879.1 - 0.055 13.4 0.1 0.3 11.0 0.0 2.2 2 1 1 3 3 2 0 NACHT domain AAA_18 PF13238.6 ELR14879.1 - 0.062 13.8 0.0 0.17 12.5 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 ELR14879.1 - 0.11 12.0 0.0 0.23 10.9 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region ABC_tran PF00005.27 ELR14879.1 - 0.17 12.4 0.1 1.3 9.5 0.0 2.2 1 1 1 2 2 2 0 ABC transporter BTB_2 PF02214.22 ELR14880.1 - 1.1e-20 73.8 0.0 3.3e-20 72.2 0.0 1.9 1 0 0 1 1 1 1 BTB/POZ domain BTB PF00651.31 ELR14880.1 - 1.5e-05 25.2 0.0 3.8e-05 23.9 0.0 1.7 1 0 0 1 1 1 1 BTB/POZ domain Macoilin PF09726.9 ELR14880.1 - 0.028 13.0 30.8 0.038 12.6 30.8 1.1 1 0 0 1 1 1 0 Macoilin family Vps36-NZF-N PF16988.5 ELR14880.1 - 0.036 13.5 2.0 0.095 12.1 2.0 1.7 1 0 0 1 1 1 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain zf-RanBP PF00641.18 ELR14880.1 - 0.14 11.5 4.1 0.22 10.9 4.1 1.3 1 0 0 1 1 1 0 Zn-finger in Ran binding protein and others TPR_MLP1_2 PF07926.12 ELR14880.1 - 0.6 10.2 61.1 0.2 11.7 31.1 3.4 3 0 0 3 3 3 0 TPR/MLP1/MLP2-like protein C2 PF00168.30 ELR14881.1 - 0.015 15.5 0.0 0.045 14.0 0.0 1.7 1 0 0 1 1 1 0 C2 domain CENP-L PF13092.6 ELR14882.1 - 1.7e-24 86.9 0.0 2.4e-24 86.4 0.0 1.2 1 0 0 1 1 1 1 Kinetochore complex Sim4 subunit Fta1 TarH PF02203.15 ELR14882.1 - 0.046 13.7 0.5 0.046 13.7 0.5 1.6 2 0 0 2 2 2 0 Tar ligand binding domain homologue Aph-1 PF06105.12 ELR14883.1 - 1e-58 198.5 22.0 1.2e-58 198.2 22.0 1.0 1 0 0 1 1 1 1 Aph-1 protein F-box-like PF12937.7 ELR14884.1 - 2.1e-09 37.1 0.1 5.6e-09 35.8 0.1 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ELR14884.1 - 1.5e-05 24.7 0.8 3.2e-05 23.7 0.1 1.9 2 0 0 2 2 2 1 F-box domain PhzC-PhzF PF02567.16 ELR14885.1 - 4e-58 197.1 0.1 5.5e-57 193.4 0.1 2.2 1 1 0 1 1 1 1 Phenazine biosynthesis-like protein DUF5572 PF17733.1 ELR14885.1 - 8.2e-06 25.6 0.7 8.2e-06 25.6 0.7 1.8 2 0 0 2 2 2 1 Family of unknown function (DUF5572) ATP-synt_E PF05680.12 ELR14885.1 - 2.2 8.7 5.5 4.2 7.8 5.5 1.4 1 0 0 1 1 1 0 ATP synthase E chain DUF1764 PF08576.10 ELR14885.1 - 6.1 7.8 8.4 1.7e+03 -0.0 8.4 2.3 1 1 0 1 1 1 0 Eukaryotic protein of unknown function (DUF1764) RTP1_C1 PF10363.9 ELR14888.1 - 1.7e-28 99.0 0.2 1.2e-27 96.3 0.1 2.5 1 1 0 1 1 1 1 Required for nuclear transport of RNA pol II C-terminus 1 HEAT_2 PF13646.6 ELR14888.1 - 4.2e-07 30.3 2.1 0.00035 20.9 0.3 3.4 2 1 0 2 2 2 2 HEAT repeats HEAT_EZ PF13513.6 ELR14888.1 - 4.7e-06 27.0 6.1 0.31 11.6 0.1 5.6 5 0 0 5 5 5 2 HEAT-like repeat HEAT_PBS PF03130.16 ELR14888.1 - 0.00085 19.8 1.4 0.016 15.8 0.0 3.9 3 0 0 3 3 3 1 PBS lyase HEAT-like repeat Cnd1 PF12717.7 ELR14888.1 - 0.0031 17.6 0.3 0.66 10.0 0.0 3.2 3 0 0 3 3 3 1 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.22 ELR14888.1 - 0.0068 16.6 2.4 2 8.9 0.1 4.6 4 0 0 4 4 4 1 HEAT repeat UNC45-central PF11701.8 ELR14888.1 - 0.035 14.1 0.1 0.25 11.3 0.0 2.5 2 0 0 2 2 2 0 Myosin-binding striated muscle assembly central CLTH PF10607.9 ELR14889.1 - 2e-30 105.6 0.0 2.6e-30 105.3 0.0 1.1 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain LisH PF08513.11 ELR14889.1 - 0.0087 16.0 0.1 0.022 14.7 0.1 1.7 1 0 0 1 1 1 1 LisH 4HB_MCP_1 PF12729.7 ELR14889.1 - 0.042 13.4 0.0 7.3 6.1 0.0 2.2 1 1 1 2 2 2 0 Four helix bundle sensory module for signal transduction Ccdc124 PF06244.12 ELR14889.1 - 0.086 13.4 0.0 0.14 12.7 0.0 1.4 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 124 /Oxs1 Ribosomal_L22 PF00237.19 ELR14889.1 - 0.16 12.2 0.1 0.74 10.1 0.1 2.0 1 1 0 1 1 1 0 Ribosomal protein L22p/L17e PP-binding PF00550.25 ELR14890.1 - 9e-10 38.8 0.1 1.3e-09 38.3 0.1 1.3 1 0 0 1 1 1 1 Phosphopantetheine attachment site PP-binding_2 PF14573.6 ELR14890.1 - 5.5e-06 26.5 0.2 7.7e-06 26.0 0.2 1.2 1 0 0 1 1 1 1 Acyl-carrier AtuA PF07287.11 ELR14890.1 - 0.15 10.8 0.0 0.15 10.7 0.0 1.1 1 0 0 1 1 1 0 Acyclic terpene utilisation family protein AtuA Ras PF00071.22 ELR14891.1 - 1.8e-07 30.9 0.0 2.4e-07 30.5 0.0 1.1 1 0 0 1 1 1 1 Ras family zf-C2H2_jaz PF12171.8 ELR14892.1 - 7.8e-05 22.9 0.1 0.00016 21.9 0.1 1.6 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding NTP_transf_2 PF01909.23 ELR14892.1 - 0.00014 22.1 0.0 0.00045 20.5 0.0 1.9 2 0 0 2 2 2 1 Nucleotidyltransferase domain RlaP PF10127.9 ELR14892.1 - 0.00031 20.4 0.0 0.0096 15.5 0.0 2.3 2 0 0 2 2 2 1 RNA repair pathway DNA polymerase beta family Med13_N PF11597.8 ELR14892.1 - 0.01 15.3 0.1 0.015 14.7 0.1 1.4 1 0 0 1 1 1 0 Mediator complex subunit 13 N-terminal zf-C2H2 PF00096.26 ELR14892.1 - 0.01 16.2 0.1 0.024 15.1 0.1 1.7 1 0 0 1 1 1 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 ELR14892.1 - 0.015 16.1 0.1 0.039 14.8 0.1 1.8 1 0 0 1 1 1 0 C2H2-type zinc finger Polbeta PF18765.1 ELR14892.1 - 0.016 15.2 0.0 0.035 14.2 0.0 1.5 1 0 0 1 1 1 0 Polymerase beta, Nucleotidyltransferase zf-C2H2_2 PF12756.7 ELR14892.1 - 0.029 14.7 0.0 0.12 12.8 0.0 2.0 1 0 0 1 1 1 0 C2H2 type zinc-finger (2 copies) zf-met PF12874.7 ELR14892.1 - 0.034 14.5 0.1 0.083 13.3 0.1 1.7 1 0 0 1 1 1 0 Zinc-finger of C2H2 type Ndc1_Nup PF09531.10 ELR14893.1 - 0.49 9.0 5.9 0.51 9.0 5.9 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Presenilin PF01080.17 ELR14893.1 - 0.51 9.1 2.4 0.67 8.7 2.4 1.2 1 0 0 1 1 1 0 Presenilin SPX PF03105.19 ELR14893.1 - 1.5 8.7 11.2 1.8 8.4 11.2 1.1 1 0 0 1 1 1 0 SPX domain DUF4551 PF15087.6 ELR14893.1 - 2 7.1 5.6 2.3 6.9 5.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) Suf PF05843.14 ELR14893.1 - 3.3 7.6 7.6 4.6 7.1 7.6 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) PetN PF03742.14 ELR14894.1 - 0.26 11.2 4.6 0.19 11.6 0.9 2.7 2 0 0 2 2 2 0 PetN LRR_6 PF13516.6 ELR14895.1 - 1.1e-25 87.5 14.5 0.0018 18.2 0.0 8.1 8 0 0 8 8 7 6 Leucine Rich repeat PH PF00169.29 ELR14895.1 - 1.4e-19 70.5 0.2 2.2e-18 66.7 0.0 2.3 2 0 0 2 2 2 1 PH domain CH PF00307.31 ELR14895.1 - 1.1e-15 57.7 0.0 2.5e-15 56.6 0.0 1.6 1 0 0 1 1 1 1 Calponin homology (CH) domain LRR_4 PF12799.7 ELR14895.1 - 2.9e-11 43.4 0.4 0.00037 20.8 0.0 5.7 4 1 3 7 7 7 4 Leucine Rich repeats (2 copies) PH_11 PF15413.6 ELR14895.1 - 1.2e-05 25.6 1.0 1.2e-05 25.6 1.0 2.7 2 1 0 2 2 2 1 Pleckstrin homology domain PH_8 PF15409.6 ELR14895.1 - 3.7e-05 23.9 0.0 8.8e-05 22.7 0.0 1.7 1 0 0 1 1 1 1 Pleckstrin homology domain LRR_8 PF13855.6 ELR14895.1 - 6.5e-05 22.6 6.9 0.011 15.5 0.7 5.2 1 1 5 6 6 6 2 Leucine rich repeat LRR_9 PF14580.6 ELR14895.1 - 0.001 18.6 0.0 0.003 17.1 0.0 1.7 1 0 0 1 1 1 1 Leucine-rich repeat CAMSAP_CH PF11971.8 ELR14895.1 - 0.011 15.6 0.0 0.041 13.7 0.0 2.0 2 0 0 2 2 2 0 CAMSAP CH domain CH_2 PF06294.11 ELR14895.1 - 0.013 15.6 0.0 0.044 13.9 0.0 2.0 1 0 0 1 1 1 0 CH-like domain in sperm protein PH_4 PF15404.6 ELR14895.1 - 0.051 13.4 0.0 0.051 13.4 0.0 2.3 2 1 0 2 2 2 0 Pleckstrin homology domain LRR_1 PF00560.33 ELR14895.1 - 0.12 13.0 0.0 2.4e+02 2.9 0.0 5.3 7 0 0 7 7 5 0 Leucine Rich Repeat Cortex-I_coil PF09304.10 ELR14895.1 - 0.2 11.9 34.0 0.066 13.4 11.1 3.8 1 1 2 3 3 3 0 Cortexillin I, coiled coil SpoU_sub_bind PF08032.12 ELR14895.1 - 0.25 11.6 2.2 27 5.1 0.0 3.9 3 0 0 3 3 2 0 RNA 2'-O ribose methyltransferase substrate binding Filament PF00038.21 ELR14895.1 - 0.27 10.8 30.6 0.016 14.8 21.5 2.4 1 1 1 2 2 2 0 Intermediate filament protein Fib_alpha PF08702.10 ELR14895.1 - 0.48 10.6 10.7 0.1 12.8 2.5 2.7 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family Med9 PF07544.13 ELR14895.1 - 0.77 9.9 12.2 0.26 11.4 2.2 3.2 1 1 1 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 FmiP_Thoc5 PF09766.9 ELR14895.1 - 0.8 8.9 21.6 1.4 8.2 21.6 1.3 1 0 0 1 1 1 0 Fms-interacting protein/Thoc5 Rota_NSP4 PF01452.16 ELR14895.1 - 1.7 8.2 3.8 9.4 5.9 1.0 2.7 2 1 1 3 3 3 0 Rotavirus non structural protein CREPT PF16566.5 ELR14895.1 - 2.2 8.4 22.8 0.34 11.1 7.9 2.6 1 1 1 2 2 2 0 Cell-cycle alteration and expression-elevated protein in tumour DUF1664 PF07889.12 ELR14895.1 - 2.5 8.2 14.3 1.4 8.9 2.6 3.2 1 1 3 4 4 4 0 Protein of unknown function (DUF1664) ADIP PF11559.8 ELR14895.1 - 2.5 8.2 34.2 1.7 8.7 14.7 2.5 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding KASH_CCD PF14662.6 ELR14895.1 - 6.4 6.6 38.4 2.8 7.7 13.7 3.5 1 1 2 3 3 3 0 Coiled-coil region of CCDC155 or KASH Syntaxin-6_N PF09177.11 ELR14895.1 - 9.5 6.8 16.2 16 6.1 3.4 3.4 2 1 1 3 3 2 0 Syntaxin 6, N-terminal DNA_pol_A_exo1 PF01612.20 ELR14896.1 - 2.1e-24 86.2 0.0 2.6e-24 85.9 0.0 1.1 1 0 0 1 1 1 1 3'-5' exonuclease HRDC PF00570.23 ELR14896.1 - 9.9e-06 25.5 0.0 2.4e-05 24.3 0.0 1.6 1 0 0 1 1 1 1 HRDC domain ART-PolyVal PF18760.1 ELR14896.1 - 0.087 13.8 0.0 0.15 13.1 0.0 1.3 1 0 0 1 1 1 0 ADP-Ribosyltransferase in polyvalent proteins Erv26 PF04148.13 ELR14898.1 - 1e-43 149.5 15.8 3.3e-43 147.9 15.8 1.7 1 1 0 1 1 1 1 Transmembrane adaptor Erv26 Ras PF00071.22 ELR14900.1 - 5e-57 192.0 0.0 5.8e-57 191.8 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR14900.1 - 9.9e-34 116.1 0.0 1.5e-33 115.6 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR14900.1 - 3.3e-12 46.2 0.0 4.2e-12 45.9 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 ELR14900.1 - 7.6e-09 35.3 0.0 8.6e-09 35.1 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 ELR14900.1 - 2.5e-07 30.8 0.0 3.3e-07 30.4 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 ELR14900.1 - 1.7e-05 24.4 0.0 0.001 18.7 0.0 2.5 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain ATP_bind_1 PF03029.17 ELR14900.1 - 0.0023 17.8 0.0 0.018 14.9 0.0 1.9 1 1 1 2 2 2 1 Conserved hypothetical ATP binding protein RsgA_GTPase PF03193.16 ELR14900.1 - 0.003 17.5 0.1 0.019 14.9 0.0 2.1 1 1 0 2 2 2 1 RsgA GTPase PduV-EutP PF10662.9 ELR14900.1 - 0.0067 16.2 0.1 0.012 15.3 0.1 1.4 1 0 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation NTPase_1 PF03266.15 ELR14900.1 - 0.0074 16.2 0.0 0.0095 15.9 0.0 1.2 1 0 0 1 1 1 1 NTPase AAA_16 PF13191.6 ELR14900.1 - 0.0092 16.4 0.0 0.0096 16.3 0.0 1.2 1 0 0 1 1 1 1 AAA ATPase domain cobW PF02492.19 ELR14900.1 - 0.0099 15.5 0.0 0.021 14.4 0.0 1.5 1 1 1 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain AAA_22 PF13401.6 ELR14900.1 - 0.01 16.1 0.0 0.015 15.5 0.0 1.4 1 1 0 1 1 1 0 AAA domain SRPRB PF09439.10 ELR14900.1 - 0.025 14.0 0.0 0.031 13.7 0.0 1.2 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit AAA_7 PF12775.7 ELR14900.1 - 0.031 13.8 0.0 0.059 12.9 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_5 PF07728.14 ELR14900.1 - 0.033 14.2 0.0 0.091 12.8 0.0 1.7 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_29 PF13555.6 ELR14900.1 - 0.055 13.2 0.0 0.1 12.4 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain MCM PF00493.23 ELR14900.1 - 0.069 12.2 0.0 0.13 11.3 0.0 1.5 1 1 1 2 2 2 0 MCM P-loop domain TniB PF05621.11 ELR14900.1 - 0.1 12.0 0.0 0.13 11.7 0.0 1.2 1 0 0 1 1 1 0 Bacterial TniB protein AAA_24 PF13479.6 ELR14900.1 - 0.12 12.1 0.0 0.19 11.4 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA PF00004.29 ELR14900.1 - 0.12 12.8 0.0 0.19 12.1 0.0 1.5 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) NACHT PF05729.12 ELR14900.1 - 0.12 12.2 0.0 0.19 11.7 0.0 1.2 1 0 0 1 1 1 0 NACHT domain Septin PF00735.18 ELR14900.1 - 0.17 11.1 0.0 0.29 10.4 0.0 1.4 1 0 0 1 1 1 0 Septin Ras PF00071.22 ELR14901.1 - 1e-35 122.7 0.1 6.9e-23 81.0 0.0 2.0 1 1 1 2 2 2 2 Ras family Roc PF08477.13 ELR14901.1 - 1.1e-18 67.5 0.0 4.4e-18 65.6 0.0 1.8 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase RsgA_GTPase PF03193.16 ELR14901.1 - 7.6e-05 22.7 0.0 0.0051 16.7 0.0 2.1 2 0 0 2 2 2 1 RsgA GTPase Arf PF00025.21 ELR14901.1 - 0.0014 18.2 0.0 0.16 11.4 0.0 2.2 1 1 0 1 1 1 1 ADP-ribosylation factor family AAA_5 PF07728.14 ELR14901.1 - 0.0029 17.6 0.0 0.013 15.5 0.0 1.9 1 1 1 2 2 2 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 ELR14901.1 - 0.004 17.6 0.2 0.007 16.8 0.2 1.7 1 1 0 1 1 1 1 AAA ATPase domain MMR_HSR1 PF01926.23 ELR14901.1 - 0.004 17.2 0.0 0.0081 16.2 0.0 1.9 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_24 PF13479.6 ELR14901.1 - 0.011 15.5 0.2 0.073 12.8 0.0 2.1 1 1 0 2 2 2 0 AAA domain ABC_tran PF00005.27 ELR14901.1 - 0.034 14.6 0.0 0.058 13.9 0.0 1.4 1 0 0 1 1 1 0 ABC transporter NACHT PF05729.12 ELR14901.1 - 0.074 13.0 0.0 0.11 12.4 0.0 1.3 1 0 0 1 1 1 0 NACHT domain PduV-EutP PF10662.9 ELR14901.1 - 0.082 12.7 0.0 0.15 11.8 0.0 1.6 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation AAA_22 PF13401.6 ELR14901.1 - 0.1 12.9 0.0 0.18 12.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.6 ELR14901.1 - 0.11 12.2 0.1 0.27 11.0 0.1 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain SapC PF07277.11 ELR14901.1 - 0.13 11.8 0.0 0.18 11.3 0.0 1.1 1 0 0 1 1 1 0 SapC FeoB_N PF02421.18 ELR14901.1 - 0.18 11.4 0.0 5.1 6.6 0.0 2.1 2 0 0 2 2 2 0 Ferrous iron transport protein B Adap_comp_sub PF00928.21 ELR14902.1 - 1.1e-69 234.8 0.0 1.4e-69 234.5 0.0 1.1 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 ELR14902.1 - 4.7e-12 46.0 0.1 8.3e-12 45.2 0.1 1.4 1 0 0 1 1 1 1 Clathrin adaptor complex small chain ABC_tran PF00005.27 ELR14903.1 - 3e-32 112.0 0.0 4.8e-15 56.3 0.0 2.5 2 1 0 2 2 2 2 ABC transporter RLI PF04068.15 ELR14903.1 - 7.1e-14 51.3 5.6 1.8e-13 50.0 5.6 1.8 1 0 0 1 1 1 1 Possible Fer4-like domain in RNase L inhibitor, RLI SMC_N PF02463.19 ELR14903.1 - 8.7e-12 44.9 3.1 0.002 17.6 0.8 4.0 3 1 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 ELR14903.1 - 3.5e-10 40.2 8.7 0.0096 15.8 0.2 4.3 2 2 2 4 4 4 4 AAA domain, putative AbiEii toxin, Type IV TA system Fer4 PF00037.27 ELR14903.1 - 2e-08 33.7 3.1 2e-08 33.7 3.1 2.3 2 0 0 2 2 2 1 4Fe-4S binding domain AAA PF00004.29 ELR14903.1 - 2.2e-06 28.2 0.0 0.096 13.1 0.0 2.7 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) Fer4_6 PF12837.7 ELR14903.1 - 4.3e-06 26.6 11.0 4.6e-06 26.5 1.6 2.4 2 0 0 2 2 2 1 4Fe-4S binding domain RsgA_GTPase PF03193.16 ELR14903.1 - 2.4e-05 24.3 0.3 0.23 11.3 0.0 2.6 2 0 0 2 2 2 2 RsgA GTPase AAA_16 PF13191.6 ELR14903.1 - 2.7e-05 24.6 0.0 0.023 15.1 0.0 2.3 2 0 0 2 2 2 1 AAA ATPase domain AAA_23 PF13476.6 ELR14903.1 - 7.3e-05 23.4 3.7 0.019 15.5 0.0 2.6 2 1 0 2 2 2 1 AAA domain AAA_22 PF13401.6 ELR14903.1 - 7.5e-05 23.0 0.0 0.031 14.5 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_15 PF13175.6 ELR14903.1 - 0.00011 22.1 9.3 0.27 10.9 0.0 4.4 5 1 0 6 6 4 2 AAA ATPase domain AAA_29 PF13555.6 ELR14903.1 - 0.00015 21.5 0.5 0.33 10.7 0.0 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain Rad17 PF03215.15 ELR14903.1 - 0.00024 21.1 0.0 0.021 14.8 0.0 2.4 2 0 0 2 2 2 1 Rad17 P-loop domain NACHT PF05729.12 ELR14903.1 - 0.0003 20.7 0.0 0.2 11.5 0.0 2.5 2 0 0 2 2 2 1 NACHT domain TsaE PF02367.17 ELR14903.1 - 0.00049 20.1 0.1 0.13 12.2 0.1 2.4 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE SRP54 PF00448.22 ELR14903.1 - 0.00073 19.2 1.1 0.25 11.0 0.0 2.3 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain AAA_28 PF13521.6 ELR14903.1 - 0.00079 19.7 0.0 0.25 11.6 0.0 2.6 2 0 0 2 2 2 1 AAA domain Fer4_2 PF12797.7 ELR14903.1 - 0.00084 19.3 0.9 0.00084 19.3 0.9 2.4 2 0 0 2 2 2 1 4Fe-4S binding domain Fer4_21 PF14697.6 ELR14903.1 - 0.0011 19.1 13.3 0.0024 17.9 13.3 1.6 1 1 0 1 1 1 1 4Fe-4S dicluster domain AAA_24 PF13479.6 ELR14903.1 - 0.0012 18.6 0.2 0.23 11.2 0.0 2.6 2 0 0 2 2 2 1 AAA domain Fer4_7 PF12838.7 ELR14903.1 - 0.0012 19.4 1.1 0.0012 19.4 1.1 2.4 1 1 0 2 2 2 1 4Fe-4S dicluster domain Fer4_10 PF13237.6 ELR14903.1 - 0.0015 18.6 1.5 0.0015 18.6 1.5 2.3 1 1 1 2 2 2 2 4Fe-4S dicluster domain AAA_18 PF13238.6 ELR14903.1 - 0.0023 18.5 0.0 3.6 8.1 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_5 PF07728.14 ELR14903.1 - 0.0026 17.8 0.8 0.52 10.3 0.0 3.5 4 0 0 4 4 3 1 AAA domain (dynein-related subfamily) MukB PF04310.12 ELR14903.1 - 0.0028 17.5 0.0 0.18 11.6 0.0 2.4 2 0 0 2 2 2 1 MukB N-terminal RNA_helicase PF00910.22 ELR14903.1 - 0.0031 17.9 0.2 5.1 7.5 0.0 2.9 3 0 0 3 3 2 0 RNA helicase AAA_30 PF13604.6 ELR14903.1 - 0.0034 17.1 0.0 0.39 10.4 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_7 PF12775.7 ELR14903.1 - 0.0041 16.7 0.0 0.6 9.6 0.0 2.3 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_33 PF13671.6 ELR14903.1 - 0.0043 17.2 0.0 2 8.5 0.0 2.6 2 0 0 2 2 2 1 AAA domain Fer4_9 PF13187.6 ELR14903.1 - 0.0057 16.8 13.0 0.012 15.8 13.0 1.5 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_16 PF13484.6 ELR14903.1 - 0.018 16.0 1.5 0.018 16.0 1.5 2.6 1 1 1 3 3 2 0 4Fe-4S double cluster binding domain MMR_HSR1 PF01926.23 ELR14903.1 - 0.02 15.0 0.3 3.2 7.9 0.0 2.6 2 0 0 2 2 2 0 50S ribosome-binding GTPase VirE PF05272.11 ELR14903.1 - 0.036 13.8 0.0 6.5 6.4 0.0 2.4 2 0 0 2 2 2 0 Virulence-associated protein E AAA_14 PF13173.6 ELR14903.1 - 0.051 13.6 1.9 6 6.9 0.0 3.2 3 1 0 3 3 2 0 AAA domain Thymidylate_kin PF02223.17 ELR14903.1 - 0.052 13.2 0.9 10 5.8 0.0 3.1 4 0 0 4 4 3 0 Thymidylate kinase NB-ARC PF00931.22 ELR14903.1 - 0.061 12.5 1.5 5.2 6.2 0.2 2.8 2 1 0 2 2 2 0 NB-ARC domain Mg_chelatase PF01078.21 ELR14903.1 - 0.072 12.5 0.6 0.92 8.9 0.0 2.3 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_PrkA PF08298.11 ELR14903.1 - 0.08 11.8 0.0 1.4 7.7 0.0 2.1 2 0 0 2 2 2 0 PrkA AAA domain AAA_19 PF13245.6 ELR14903.1 - 0.13 12.6 0.1 3.1 8.1 0.0 2.4 2 0 0 2 2 2 0 AAA domain RuvB_N PF05496.12 ELR14903.1 - 0.15 11.8 0.0 24 4.6 0.0 2.4 2 0 0 2 2 2 0 Holliday junction DNA helicase RuvB P-loop domain Fer4_4 PF12800.7 ELR14903.1 - 0.3 11.7 15.0 0.15 12.6 3.1 2.4 2 0 0 2 2 2 0 4Fe-4S binding domain NTPase_1 PF03266.15 ELR14903.1 - 0.38 10.7 2.8 15 5.5 0.1 3.3 3 0 0 3 3 3 0 NTPase Zeta_toxin PF06414.12 ELR14903.1 - 0.39 10.0 2.8 4.8 6.4 0.0 3.4 4 0 0 4 4 4 0 Zeta toxin Fer4_8 PF13183.6 ELR14903.1 - 9.5 6.8 11.9 0.32 11.5 1.5 2.2 1 1 1 2 2 2 0 4Fe-4S dicluster domain CBFD_NFYB_HMF PF00808.23 ELR14904.1 - 9.4e-10 38.6 0.3 1.7e-09 37.9 0.3 1.4 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Bromo_TP PF07524.13 ELR14904.1 - 0.00091 19.2 0.0 0.0015 18.5 0.0 1.4 1 0 0 1 1 1 1 Bromodomain associated Histone PF00125.24 ELR14904.1 - 0.01 16.2 0.3 0.018 15.4 0.3 1.4 1 0 0 1 1 1 0 Core histone H2A/H2B/H3/H4 TAF PF02969.17 ELR14904.1 - 0.024 14.8 0.2 0.039 14.1 0.2 1.3 1 0 0 1 1 1 0 TATA box binding protein associated factor (TAF) CENP-T_C PF15511.6 ELR14904.1 - 0.034 14.2 0.2 0.22 11.7 0.0 2.0 1 1 1 2 2 2 0 Centromere kinetochore component CENP-T histone fold DNA_pol3_chi PF04364.13 ELR14904.1 - 0.035 14.3 0.2 0.049 13.8 0.1 1.3 1 1 0 1 1 1 0 DNA polymerase III chi subunit, HolC DUF4872 PF16169.5 ELR14904.1 - 0.048 13.4 0.4 0.062 13.1 0.3 1.2 1 1 0 1 1 1 0 Domain of unknown function (DUF4872) CTD_bind PF04818.13 ELR14904.1 - 0.57 11.1 2.8 3.5 8.5 1.3 2.5 1 1 1 2 2 2 0 RNA polymerase II-binding domain. CitMHS PF03600.16 ELR14905.1 - 2.6e-53 181.2 15.1 2.6e-53 181.2 15.1 2.0 2 0 0 2 2 2 1 Citrate transporter CitMHS_2 PF16980.5 ELR14905.1 - 7e-05 21.7 23.3 0.0075 15.0 10.8 2.5 2 0 0 2 2 2 2 Putative citrate transport K_channel_TID PF07941.11 ELR14905.1 - 0.0046 17.4 1.2 0.01 16.3 1.2 1.5 1 0 0 1 1 1 1 Potassium channel Kv1.4 tandem inactivation domain GrpE PF01025.19 ELR14905.1 - 0.085 12.5 1.7 0.14 11.8 1.7 1.3 1 0 0 1 1 1 0 GrpE ArsB PF02040.15 ELR14905.1 - 0.39 10.0 30.5 0.98 8.7 8.9 2.2 2 0 0 2 2 2 0 Arsenical pump membrane protein SRAP PF02586.14 ELR14906.1 - 1.6e-69 233.8 0.0 2.5e-69 233.1 0.0 1.3 1 0 0 1 1 1 1 SOS response associated peptidase (SRAP) CDC45 PF02724.14 ELR14906.1 - 0.21 9.9 20.1 0.25 9.6 20.1 1.1 1 0 0 1 1 1 0 CDC45-like protein RR_TM4-6 PF06459.12 ELR14906.1 - 3.1 7.5 19.1 5.4 6.8 19.1 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 CCSAP PF15748.5 ELR14906.1 - 3.6 7.7 22.4 5.5 7.1 22.4 1.3 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated Nucleo_P87 PF07267.11 ELR14906.1 - 4.4 6.1 12.0 5.9 5.6 12.0 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 CDC27 PF09507.10 ELR14906.1 - 7.6 5.8 32.6 10 5.4 32.6 1.2 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 MAPEG PF01124.18 ELR14907.1 - 2.8e-21 75.8 3.5 3.6e-21 75.4 3.5 1.1 1 0 0 1 1 1 1 MAPEG family VSG_B PF13206.6 ELR14908.1 - 0.021 14.1 3.2 0.028 13.7 3.2 1.2 1 0 0 1 1 1 0 Trypanosomal VSG domain Phasin_2 PF09361.10 ELR14908.1 - 0.031 14.5 0.7 0.19 12.0 0.4 2.3 1 1 1 2 2 2 0 Phasin protein Rtf2 PF04641.12 ELR14908.1 - 0.49 9.7 7.6 1.1 8.6 7.6 1.6 1 1 0 1 1 1 0 Rtf2 RING-finger AIM3 PF17096.5 ELR14908.1 - 1.9 9.5 12.4 7.1 7.6 0.0 3.2 3 0 0 3 3 3 0 Altered inheritance of mitochondria protein 3 Perilipin PF03036.16 ELR14908.1 - 2 7.3 11.8 2.2 7.2 11.1 1.4 1 1 0 1 1 1 0 Perilipin family Stomoxyn PF11585.8 ELR14908.1 - 7.1 6.7 10.2 0.51 10.4 1.5 2.8 3 0 0 3 3 3 0 Insect antimicrobial peptide, stomoxyn Ribosomal_L44 PF00935.19 ELR14909.1 - 3e-35 120.5 11.5 3e-35 120.5 11.5 1.6 1 1 1 2 2 2 1 Ribosomal protein L44 DUF1272 PF06906.11 ELR14909.1 - 0.02 15.0 0.5 4.8 7.3 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1272) Cathelicidins PF00666.17 ELR14909.1 - 0.29 11.5 6.9 0.085 13.2 2.5 1.9 2 0 0 2 2 2 0 Cathelicidin Jiv90 PF14901.6 ELR14909.1 - 0.72 10.0 7.1 2.4 8.4 0.5 2.2 2 0 0 2 2 2 0 Cleavage inducing molecular chaperone NOB1_Zn_bind PF08772.11 ELR14909.1 - 1.9 8.7 11.0 0.1 12.8 3.5 2.2 1 1 1 2 2 2 0 Nin one binding (NOB1) Zn-ribbon like Cript PF10235.9 ELR14909.1 - 5.3 7.7 13.6 7.1 7.3 4.3 2.2 1 1 1 2 2 2 0 Microtubule-associated protein CRIPT FKBP_C PF00254.28 ELR14910.1 - 3.6e-19 68.9 0.0 8.8e-19 67.6 0.0 1.7 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase VID27_PH PF17747.1 ELR14910.1 - 0.025 14.8 0.4 0.055 13.8 0.4 1.5 1 0 0 1 1 1 0 VID27 PH-like domain RGS PF00615.19 ELR14911.1 - 5.3e-20 71.9 1.7 8.6e-20 71.2 1.7 1.3 1 0 0 1 1 1 1 Regulator of G protein signaling domain OFCC1 PF15680.5 ELR14911.1 - 0.11 13.1 0.0 0.59 10.7 0.0 2.1 2 0 0 2 2 2 0 Orofacial cleft 1 candidate gene 1 protein EFTUD2 PF16004.5 ELR14912.1 - 3 8.4 7.6 0.23 12.1 1.3 2.3 2 0 0 2 2 2 0 116 kDa U5 small nuclear ribonucleoprotein component N-terminus ThiF PF00899.21 ELR14913.1 - 2.1e-32 112.4 0.1 3.3e-32 111.8 0.1 1.2 1 0 0 1 1 1 1 ThiF family NAD_binding_7 PF13241.6 ELR14913.1 - 1.4e-06 28.6 0.4 5e-06 26.9 0.1 2.0 2 0 0 2 2 2 1 Putative NAD(P)-binding Sacchrp_dh_NADP PF03435.18 ELR14913.1 - 0.00015 22.0 0.8 0.00074 19.8 0.7 2.1 1 1 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain FAD_binding_3 PF01494.19 ELR14913.1 - 0.00075 18.8 0.7 0.01 15.1 0.2 2.3 2 0 0 2 2 2 1 FAD binding domain Shikimate_DH PF01488.20 ELR14913.1 - 0.0034 17.4 0.2 0.0086 16.1 0.0 1.8 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase TrkA_N PF02254.18 ELR14913.1 - 0.012 15.9 1.1 0.04 14.2 0.2 2.4 2 0 0 2 2 2 0 TrkA-N domain DAO PF01266.24 ELR14913.1 - 0.015 14.9 0.1 0.026 14.1 0.1 1.4 1 0 0 1 1 1 0 FAD dependent oxidoreductase AlaDh_PNT_C PF01262.21 ELR14913.1 - 0.023 14.0 0.2 0.064 12.5 0.1 1.8 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain ApbA PF02558.16 ELR14913.1 - 0.1 12.2 0.1 0.2 11.3 0.1 1.5 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA Ras PF00071.22 ELR14915.1 - 9.6e-29 100.1 0.1 1.1e-28 99.9 0.1 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR14915.1 - 3.5e-25 88.5 0.0 4e-25 88.4 0.0 1.0 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR14915.1 - 5.1e-11 42.3 0.1 5.7e-11 42.2 0.1 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 ELR14915.1 - 1e-07 31.7 0.2 3.2e-05 23.6 0.0 2.0 1 1 1 2 2 2 2 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 ELR14915.1 - 8.9e-06 25.8 0.0 1.1e-05 25.5 0.0 1.1 1 0 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.10 ELR14915.1 - 0.0085 15.5 0.0 0.0098 15.3 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit TniB PF05621.11 ELR14915.1 - 0.026 13.9 0.0 0.034 13.5 0.0 1.3 1 0 0 1 1 1 0 Bacterial TniB protein Dynamin_N PF00350.23 ELR14915.1 - 0.05 13.7 0.0 0.13 12.3 0.0 1.6 2 0 0 2 2 2 0 Dynamin family AAA_24 PF13479.6 ELR14915.1 - 0.07 12.9 0.1 0.51 10.0 0.0 1.9 1 1 1 2 2 2 0 AAA domain RRM_1 PF00076.22 ELR14916.1 - 7.7e-19 67.3 0.8 1.2e-18 66.7 0.1 1.6 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 ELR14916.1 - 6.8e-07 28.9 0.0 8e-07 28.7 0.0 1.1 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 ELR14916.1 - 0.024 14.7 0.2 0.067 13.3 0.2 1.9 1 1 0 1 1 1 0 RNA recognition motif AAA_18 PF13238.6 ELR14917.1 - 0.0067 17.0 0.1 0.02 15.5 0.1 1.8 1 1 0 1 1 1 1 AAA domain PP2C PF00481.21 ELR14918.1 - 0.0002 21.1 0.0 0.00067 19.4 0.0 1.7 2 0 0 2 2 2 1 Protein phosphatase 2C SpoIIE PF07228.12 ELR14918.1 - 0.012 15.6 0.0 0.027 14.4 0.0 1.7 1 1 0 1 1 1 0 Stage II sporulation protein E (SpoIIE) SMC_N PF02463.19 ELR14919.1 - 4.1e-29 101.6 0.2 4.7e-29 101.4 0.2 1.0 1 0 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 ELR14919.1 - 2.5e-13 51.0 0.3 3e-13 50.7 0.3 1.0 1 0 0 1 1 1 1 AAA domain AAA_21 PF13304.6 ELR14919.1 - 7.7e-07 29.2 0.2 8.8e-07 29.0 0.2 1.1 1 0 0 1 1 1 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 ELR14919.1 - 1.4e-05 24.7 0.0 2.8e-05 23.7 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_15 PF13175.6 ELR14919.1 - 1.9e-05 24.6 0.1 1.9e-05 24.5 0.1 1.1 1 0 0 1 1 1 1 AAA ATPase domain ABC_tran PF00005.27 ELR14919.1 - 0.053 14.0 0.5 0.07 13.6 0.5 1.4 1 1 0 1 1 1 0 ABC transporter DUF2813 PF11398.8 ELR14919.1 - 0.082 12.1 0.0 0.085 12.1 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2813) APG6_N PF17675.1 ELR14920.1 - 0.0048 17.4 14.9 0.0048 17.4 14.9 3.9 2 1 2 4 4 4 2 Apg6 coiled-coil region ERM PF00769.19 ELR14920.1 - 0.03 14.1 56.4 0.029 14.2 20.6 2.4 1 1 1 2 2 2 0 Ezrin/radixin/moesin family AAA_13 PF13166.6 ELR14920.1 - 1.2 7.7 36.2 0.24 10.0 24.0 2.1 2 0 0 2 2 2 0 AAA domain Fez1 PF06818.15 ELR14920.1 - 1.2 9.5 45.1 0.69 10.3 28.0 2.6 1 1 1 2 2 2 0 Fez1 ATG16 PF08614.11 ELR14920.1 - 1.9 8.7 48.4 7 6.8 36.1 3.1 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) Tropomyosin_1 PF12718.7 ELR14920.1 - 2 8.5 53.6 8.7 6.5 18.5 3.1 1 1 1 2 2 2 0 Tropomyosin like CALCOCO1 PF07888.11 ELR14920.1 - 5.9 5.6 48.8 0.54 9.1 22.8 2.4 1 1 0 2 2 2 0 Calcium binding and coiled-coil domain (CALCOCO1) like GAS PF13851.6 ELR14920.1 - 7.1 5.9 54.0 0.074 12.4 17.2 3.3 1 1 2 3 3 3 0 Growth-arrest specific micro-tubule binding DUF2730 PF10805.8 ELR14920.1 - 8.4 6.6 19.0 0.16 12.1 6.0 3.5 1 1 1 3 3 3 0 Protein of unknown function (DUF2730) PDDEXK_1 PF12705.7 ELR14921.1 - 0.0022 17.9 0.0 0.0037 17.2 0.0 1.3 1 1 0 1 1 1 1 PD-(D/E)XK nuclease superfamily Cas_Cas4 PF01930.17 ELR14921.1 - 0.0044 17.1 0.6 0.11 12.6 0.0 2.1 2 0 0 2 2 2 1 Domain of unknown function DUF83 AAA_11 PF13086.6 ELR14922.1 - 8.2e-15 55.3 2.8 2.4e-06 27.5 0.1 2.8 2 1 1 3 3 3 2 AAA domain AAA_30 PF13604.6 ELR14922.1 - 1.1e-12 48.1 0.0 3.1e-12 46.6 0.0 1.8 1 1 0 1 1 1 1 AAA domain AAA_12 PF13087.6 ELR14922.1 - 1.6e-10 40.9 0.0 1.5e-09 37.8 0.0 2.2 1 1 0 1 1 1 1 AAA domain UvrD_C_2 PF13538.6 ELR14922.1 - 2.2e-08 33.8 0.0 1.7e-07 31.0 0.0 2.5 2 0 0 2 2 2 1 UvrD-like helicase C-terminal domain AAA_19 PF13245.6 ELR14922.1 - 2.2e-06 28.1 0.0 8e-06 26.2 0.0 1.9 1 1 0 1 1 1 1 AAA domain Viral_helicase1 PF01443.18 ELR14922.1 - 0.0029 17.4 0.0 1.4 8.6 0.0 3.0 3 0 0 3 3 3 1 Viral (Superfamily 1) RNA helicase PhoH PF02562.16 ELR14922.1 - 0.0064 16.0 0.0 0.088 12.2 0.0 2.1 2 0 0 2 2 2 1 PhoH-like protein Helicase_RecD PF05127.14 ELR14922.1 - 0.016 15.1 0.0 0.095 12.6 0.0 2.3 1 1 0 1 1 1 0 Helicase AAA_25 PF13481.6 ELR14922.1 - 0.02 14.4 0.0 0.045 13.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 ELR14922.1 - 0.066 13.5 0.0 0.45 10.8 0.0 2.3 1 1 0 1 1 1 0 AAA domain TMEM135_C_rich PF15982.5 ELR14923.1 - 4.1e-09 37.2 2.4 8.2e-09 36.2 2.4 1.5 1 0 0 1 1 1 1 N-terminal cysteine-rich region of Transmembrane protein 135 MadM PF03818.13 ELR14923.1 - 0.79 9.6 3.2 4.5 7.2 0.0 3.3 3 0 0 3 3 3 0 Malonate/sodium symporter MadM subunit PhoR PF11808.8 ELR14923.1 - 2.5 8.6 6.8 0.86 10.1 0.6 3.1 2 1 1 3 3 3 0 Phosphate regulon sensor protein PhoR 2OG-FeII_Oxy_2 PF13532.6 ELR14924.1 - 4.3e-07 30.3 0.1 4.7e-07 30.2 0.1 1.0 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_2 PF13532.6 ELR14925.1 - 0.021 15.0 0.0 0.57 10.3 0.0 1.9 1 1 1 2 2 2 0 2OG-Fe(II) oxygenase superfamily Peptidase_C1 PF00112.23 ELR14926.1 - 2.3e-83 279.6 4.6 3.1e-83 279.2 4.6 1.2 1 0 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.12 ELR14926.1 - 5e-15 55.7 8.6 8.5e-15 54.9 8.6 1.4 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Peptidase_C1_2 PF03051.15 ELR14926.1 - 5.2e-05 22.2 2.6 0.0061 15.4 0.3 2.2 2 0 0 2 2 2 2 Peptidase C1-like family SMN PF06003.12 ELR14927.1 - 0.17 11.1 5.8 0.33 10.2 5.8 1.4 1 0 0 1 1 1 0 Survival motor neuron protein (SMN) Ribonuc_P_40 PF08584.11 ELR14927.1 - 0.25 10.6 0.0 0.25 10.6 0.0 1.6 2 0 0 2 2 2 0 Ribonuclease P 40kDa (Rpp40) subunit Ank_4 PF13637.6 ELR14928.1 - 3.6e-19 68.9 0.2 6.2e-07 29.9 0.0 3.3 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 ELR14928.1 - 2e-17 63.6 0.7 2.3e-07 31.3 0.1 2.4 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.30 ELR14928.1 - 3.9e-17 61.8 0.8 1.2e-05 25.5 0.0 4.3 4 0 0 4 4 4 3 Ankyrin repeat Ank_5 PF13857.6 ELR14928.1 - 4e-16 58.9 6.6 8.2e-06 26.0 0.2 3.8 2 1 2 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 ELR14928.1 - 2.7e-13 48.8 0.2 0.004 17.5 0.1 4.5 4 0 0 4 4 4 3 Ankyrin repeat zf-MYND PF01753.18 ELR14928.1 - 2.8e-12 46.5 12.6 4.5e-12 45.8 12.6 1.4 1 0 0 1 1 1 1 MYND finger zf-C6H2 PF15801.5 ELR14928.1 - 0.058 13.7 10.0 0.096 13.0 10.0 1.4 1 0 0 1 1 1 0 zf-MYND-like zinc finger, mRNA-binding JHD PF17811.1 ELR14929.1 - 0.051 14.1 0.1 0.079 13.5 0.1 1.3 1 0 0 1 1 1 0 Jumonji helical domain MFS_1 PF07690.16 ELR14930.1 - 3.6e-30 105.1 22.6 3.6e-30 105.1 22.6 2.5 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 ELR14930.1 - 8.7e-15 54.5 0.7 8.7e-15 54.5 0.7 2.2 2 0 0 2 2 2 1 Sugar (and other) transporter RasGEF PF00617.19 ELR14931.1 - 3.1e-62 209.9 0.4 5.9e-62 209.0 0.4 1.5 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 ELR14931.1 - 8.7e-24 83.8 0.1 3.1e-23 82.0 0.1 2.0 1 0 0 1 1 1 1 RasGEF N-terminal motif DUF2126 PF09899.9 ELR14931.1 - 0.18 9.8 2.7 0.26 9.3 2.7 1.1 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) SprA-related PF12118.8 ELR14931.1 - 3.8 6.6 11.1 3.7 6.6 7.2 2.1 2 0 0 2 2 2 0 SprA-related family NARP1 PF12569.8 ELR14931.1 - 4.5 6.1 13.4 7 5.4 13.4 1.2 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 Biopterin_H PF00351.21 ELR14932.1 - 3.6e-169 562.1 0.0 4.9e-169 561.6 0.0 1.2 1 0 0 1 1 1 1 Biopterin-dependent aromatic amino acid hydroxylase ACT PF01842.25 ELR14932.1 - 3.5e-08 33.1 0.0 6e-08 32.3 0.0 1.4 1 0 0 1 1 1 1 ACT domain ACT_5 PF13710.6 ELR14932.1 - 0.14 12.0 0.0 0.25 11.2 0.0 1.5 1 0 0 1 1 1 0 ACT domain SNF2_N PF00176.23 ELR14933.1 - 2e-55 188.0 0.0 3.5e-55 187.1 0.0 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 ELR14933.1 - 1.7e-14 54.1 0.0 1.6e-13 50.9 0.0 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 ELR14933.1 - 1.9e-09 37.7 0.0 3.6e-09 36.8 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit HDA2-3 PF11496.8 ELR14933.1 - 0.032 13.4 0.0 0.25 10.5 0.0 2.1 1 1 0 1 1 1 0 Class II histone deacetylase complex subunits 2 and 3 SWI2_SNF2 PF18766.1 ELR14933.1 - 0.066 12.9 0.0 0.12 12.0 0.0 1.4 1 0 0 1 1 1 0 SWI2/SNF2 ATPase DUF2439 PF10382.9 ELR14933.1 - 0.11 12.8 0.0 0.28 11.5 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2439) Aminotran_5 PF00266.19 ELR14934.1 - 1.3e-27 96.7 0.0 1.5e-25 89.9 0.0 2.1 2 0 0 2 2 2 2 Aminotransferase class-V Cys_Met_Meta_PP PF01053.20 ELR14934.1 - 1.3e-05 23.9 0.0 1.9e-05 23.4 0.0 1.1 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_1_2 PF00155.21 ELR14934.1 - 2.6e-05 23.6 0.0 4.1e-05 22.9 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II DegT_DnrJ_EryC1 PF01041.17 ELR14934.1 - 0.01 15.2 0.0 0.028 13.7 0.0 1.6 1 1 0 1 1 1 0 DegT/DnrJ/EryC1/StrS aminotransferase family Beta_elim_lyase PF01212.21 ELR14934.1 - 0.14 11.4 0.0 0.85 8.8 0.0 2.1 2 1 0 2 2 2 0 Beta-eliminating lyase Gallidermin PF02052.15 ELR14934.1 - 4.9 7.6 6.3 4.8 7.6 2.9 2.3 2 0 0 2 2 2 0 Gallidermin Ras PF00071.22 ELR14935.1 - 7.2e-21 74.5 0.0 1.1e-20 73.8 0.0 1.3 1 0 0 1 1 1 1 Ras family Ank PF00023.30 ELR14935.1 - 7.1e-09 35.7 0.1 0.00012 22.4 0.0 3.7 3 0 0 3 3 3 2 Ankyrin repeat Ank_2 PF12796.7 ELR14935.1 - 7.2e-09 36.1 0.0 1.7e-08 34.9 0.0 1.6 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 ELR14935.1 - 7.8e-09 35.6 0.1 1.6e-08 34.7 0.1 1.6 1 0 0 1 1 1 1 Ankyrin repeats (many copies) F-box-like PF12937.7 ELR14935.1 - 1.8e-08 34.1 2.7 3.9e-08 33.0 2.7 1.6 1 0 0 1 1 1 1 F-box-like Ank_4 PF13637.6 ELR14935.1 - 2e-08 34.6 0.0 6e-07 29.9 0.0 2.7 1 1 1 2 2 2 2 Ankyrin repeats (many copies) F-box PF00646.33 ELR14935.1 - 2.6e-07 30.3 1.2 5.8e-07 29.2 1.2 1.6 1 0 0 1 1 1 1 F-box domain Ank_3 PF13606.6 ELR14935.1 - 5.8e-07 29.3 0.0 0.0014 18.9 0.0 3.6 3 0 0 3 3 3 1 Ankyrin repeat Roc PF08477.13 ELR14935.1 - 8.4e-07 29.2 0.0 1.7e-06 28.3 0.0 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase F-box_4 PF15966.5 ELR14935.1 - 0.044 13.7 0.0 0.31 10.9 0.1 2.1 2 0 0 2 2 2 0 F-box Elongin_A PF06881.11 ELR14935.1 - 0.072 13.6 0.0 0.18 12.3 0.0 1.6 1 0 0 1 1 1 0 RNA polymerase II transcription factor SIII (Elongin) subunit A SelR PF01641.18 ELR14936.1 - 9.9e-21 74.1 0.1 1.4e-20 73.6 0.1 1.2 1 0 0 1 1 1 1 SelR domain Yippee-Mis18 PF03226.14 ELR14936.1 - 0.089 13.0 0.3 0.23 11.7 0.3 1.6 1 1 0 1 1 1 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly VCBS PF13517.6 ELR14937.1 - 5e-05 23.8 0.0 0.065 13.8 0.0 2.9 2 0 0 2 2 2 2 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.23 ELR14937.1 - 0.042 14.0 5.1 0.52 10.5 0.0 3.2 3 0 0 3 3 3 0 FG-GAP repeat BBS2_Mid PF14783.6 ELR14937.1 - 0.092 12.8 0.0 0.2 11.7 0.0 1.5 1 0 0 1 1 1 0 Ciliary BBSome complex subunit 2, middle region DUF1765 PF08578.10 ELR14938.1 - 1e-10 42.2 3.1 1.8e-10 41.4 3.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1765) CDC27 PF09507.10 ELR14938.1 - 0.0052 16.2 11.1 0.0052 16.2 11.1 2.0 2 0 0 2 2 2 1 DNA polymerase subunit Cdc27 EIF4E-T PF10477.9 ELR14938.1 - 0.052 12.4 11.1 0.075 11.9 11.1 1.2 1 0 0 1 1 1 0 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E Raftlin PF15250.6 ELR14938.1 - 0.39 9.4 2.8 0.56 8.9 2.8 1.1 1 0 0 1 1 1 0 Raftlin PPP4R2 PF09184.11 ELR14938.1 - 1.2 8.7 17.8 0.27 10.8 14.3 1.6 2 0 0 2 2 2 0 PPP4R2 Nop14 PF04147.12 ELR14938.1 - 2 6.5 18.6 2.9 6.0 18.6 1.1 1 0 0 1 1 1 0 Nop14-like family Zip PF02535.22 ELR14938.1 - 2.5 7.2 6.1 5.6 6.1 6.1 1.5 1 0 0 1 1 1 0 ZIP Zinc transporter Vfa1 PF08432.10 ELR14938.1 - 4.7 7.5 12.1 7.9 6.8 12.1 1.3 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 ubiquitin PF00240.23 ELR14939.1 - 7.1e-13 48.1 0.3 8.5e-13 47.9 0.3 1.1 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 ELR14939.1 - 3.1e-10 39.7 0.5 4.1e-10 39.3 0.5 1.2 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like HORMA PF02301.18 ELR14940.1 - 1.4e-21 77.0 0.0 6.2e-21 75.0 0.0 1.8 1 1 0 1 1 1 1 HORMA domain bacHORMA_2 PF18173.1 ELR14940.1 - 0.0087 15.9 0.1 0.018 14.9 0.1 1.5 1 0 0 1 1 1 1 Bacterial HORMA domain 2 RRM_1 PF00076.22 ELR14941.1 - 8.1e-20 70.4 0.0 6.7e-06 25.8 0.0 4.2 3 1 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) UreE_C PF05194.12 ELR14941.1 - 0.025 15.0 3.9 0.025 15.0 3.9 2.0 2 0 0 2 2 2 0 UreE urease accessory protein, C-terminal domain GTP_EFTU PF00009.27 ELR14942.1 - 4.9e-54 182.8 0.1 7.5e-54 182.2 0.1 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 ELR14942.1 - 1.2e-21 77.1 0.9 3.1e-21 75.8 0.0 2.2 2 0 0 2 2 2 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 ELR14942.1 - 3.7e-16 59.3 4.4 3.7e-16 59.3 4.4 2.1 3 0 0 3 3 3 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 ELR14942.1 - 0.00016 21.7 0.1 0.0003 20.8 0.1 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase cobW PF02492.19 ELR14942.1 - 0.0053 16.4 0.2 0.013 15.0 0.0 1.7 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain Septin PF00735.18 ELR14942.1 - 0.061 12.6 0.1 0.42 9.8 0.0 1.9 2 0 0 2 2 2 0 Septin S1-like PF14444.6 ELR14942.1 - 0.83 9.6 3.2 4.8 7.2 0.0 3.4 5 0 0 5 5 5 0 S1-like Pkinase PF00069.25 ELR14943.1 - 2.8e-78 262.9 0.0 3.9e-78 262.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR14943.1 - 2.6e-43 148.2 0.0 4.3e-43 147.5 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase KA1 PF02149.19 ELR14943.1 - 3.7e-18 65.0 0.0 6.6e-18 64.2 0.0 1.4 1 0 0 1 1 1 1 Kinase associated domain 1 Kinase-like PF14531.6 ELR14943.1 - 1.2e-07 31.4 0.0 1.7e-06 27.6 0.0 2.1 2 0 0 2 2 2 1 Kinase-like UBA PF00627.31 ELR14943.1 - 0.00017 21.4 0.0 0.00029 20.6 0.0 1.4 1 0 0 1 1 1 1 UBA/TS-N domain RIO1 PF01163.22 ELR14943.1 - 0.00023 20.8 0.6 0.00052 19.7 0.6 1.5 1 0 0 1 1 1 1 RIO1 family APH PF01636.23 ELR14943.1 - 0.0003 20.8 0.4 0.97 9.3 1.2 3.3 2 1 1 3 3 3 2 Phosphotransferase enzyme family Haspin_kinase PF12330.8 ELR14943.1 - 0.00071 18.6 0.5 0.0011 18.0 0.5 1.2 1 0 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 ELR14943.1 - 0.0011 18.3 0.2 0.0019 17.6 0.2 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase PF00069.25 ELR14944.1 - 1.1e-71 241.4 0.0 1.4e-71 240.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR14944.1 - 3.5e-54 183.8 0.0 4.9e-54 183.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase DUF1241 PF06840.11 ELR14944.1 - 6.9e-06 25.8 0.1 1.8e-05 24.4 0.1 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF1241) Pkinase_fungal PF17667.1 ELR14944.1 - 1.4e-05 24.1 0.3 6.2e-05 22.0 0.0 2.0 2 0 0 2 2 2 1 Fungal protein kinase Kinase-like PF14531.6 ELR14944.1 - 0.00017 21.0 0.0 0.00076 18.9 0.0 1.9 2 0 0 2 2 2 1 Kinase-like Haspin_kinase PF12330.8 ELR14944.1 - 0.00033 19.7 0.0 0.0041 16.1 0.0 2.1 1 1 0 1 1 1 1 Haspin like kinase domain CDC45 PF02724.14 ELR14944.1 - 0.06 11.6 4.5 0.087 11.1 4.5 1.1 1 0 0 1 1 1 0 CDC45-like protein ABC1 PF03109.16 ELR14944.1 - 0.11 12.7 0.1 0.3 11.3 0.0 1.7 2 0 0 2 2 2 0 ABC1 family SDA1 PF05285.12 ELR14944.1 - 0.17 11.3 9.9 0.25 10.7 9.9 1.2 1 0 0 1 1 1 0 SDA1 Atg8 PF02991.16 ELR14945.1 - 2.6e-46 156.0 0.1 3.1e-46 155.8 0.1 1.0 1 0 0 1 1 1 1 Autophagy protein Atg8 ubiquitin like APG12 PF04110.13 ELR14945.1 - 3.4e-08 33.8 0.0 4.2e-08 33.5 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-like autophagy protein Apg12 DOCK-C2 PF14429.6 ELR14946.1 - 1.7e-38 132.4 0.0 1.2e-37 129.7 0.0 2.2 3 0 0 3 3 3 1 C2 domain in Dock180 and Zizimin proteins DUF3398 PF11878.8 ELR14946.1 - 2.4e-08 34.4 0.1 5.4e-08 33.3 0.1 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF3398) DOCK_N PF16172.5 ELR14946.1 - 0.087 11.7 0.0 0.19 10.6 0.0 1.5 1 0 0 1 1 1 0 DOCK N-terminus DHR-2 PF06920.13 ELR14947.1 - 3e-57 194.5 2.0 7.3e-36 123.9 0.6 3.1 2 1 1 3 3 3 3 Dock homology region 2 FlgN PF05130.12 ELR14947.1 - 0.014 15.9 3.8 0.089 13.3 1.0 3.2 3 1 0 3 3 3 0 FlgN protein SQHop_cyclase_N PF13249.6 ELR14947.1 - 0.046 12.8 0.0 0.085 11.9 0.0 1.3 1 0 0 1 1 1 0 Squalene-hopene cyclase N-terminal domain TPR_1 PF00515.28 ELR14947.1 - 0.24 11.3 2.8 19 5.3 0.0 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat HATPase_c PF02518.26 ELR14948.1 - 6.4e-32 110.4 0.1 2e-31 108.8 0.1 1.8 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 ELR14948.1 - 6.9e-17 61.6 0.0 1.5e-16 60.6 0.0 1.6 1 0 0 1 1 1 1 Response regulator receiver domain HisKA PF00512.25 ELR14948.1 - 3.7e-16 58.9 0.0 7.7e-16 57.9 0.0 1.6 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain GAF PF01590.26 ELR14948.1 - 1e-05 26.1 0.0 3.9e-05 24.3 0.0 2.0 1 1 0 1 1 1 1 GAF domain UPF0242 PF06785.11 ELR14948.1 - 0.039 14.1 0.0 0.13 12.4 0.0 1.9 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus GRIP PF01465.20 ELR14948.1 - 0.1 12.5 0.0 18 5.3 0.0 2.6 2 0 0 2 2 2 0 GRIP domain PH PF00169.29 ELR14949.1 - 0.0051 17.3 0.0 0.0086 16.6 0.0 1.3 1 0 0 1 1 1 1 PH domain MMM1 PF10296.9 ELR14949.1 - 0.17 10.9 0.0 0.36 9.8 0.0 1.5 2 0 0 2 2 2 0 Maintenance of mitochondrial morphology protein 1 Str_synth PF03088.16 ELR14951.1 - 2.8e-18 65.8 0.0 1.7e-17 63.3 0.0 2.2 2 1 1 3 3 3 1 Strictosidine synthase SGL PF08450.12 ELR14951.1 - 1.2e-11 44.6 0.0 1.6e-10 41.0 0.0 2.1 1 1 0 1 1 1 1 SMP-30/Gluconolactonase/LRE-like region DAO PF01266.24 ELR14954.1 - 3.6e-13 49.8 0.0 4.1e-13 49.7 0.0 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 ELR14954.1 - 3.7e-07 30.3 2.0 1.9e-06 28.0 1.7 2.1 1 1 1 2 2 2 1 NAD(P)-binding Rossmann-like domain FAD_binding_3 PF01494.19 ELR14954.1 - 1.9e-06 27.3 1.5 2.8e-06 26.8 1.4 1.3 1 1 0 1 1 1 1 FAD binding domain FAD_binding_2 PF00890.24 ELR14954.1 - 5.6e-06 25.7 1.9 7.6e-06 25.3 1.9 1.3 1 1 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 ELR14954.1 - 8.4e-06 25.2 0.1 9.4e-06 25.1 0.1 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 ELR14954.1 - 2.4e-05 23.7 0.4 3.2e-05 23.3 0.4 1.2 1 0 0 1 1 1 1 Thi4 family FAD_oxidored PF12831.7 ELR14954.1 - 0.0001 21.8 0.3 0.00011 21.7 0.3 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase HI0933_like PF03486.14 ELR14954.1 - 0.00033 19.5 0.6 0.00072 18.4 0.4 1.5 1 1 0 1 1 1 1 HI0933-like protein Pyr_redox_3 PF13738.6 ELR14954.1 - 0.00055 19.3 0.3 0.00082 18.7 0.2 1.3 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 ELR14954.1 - 0.0052 15.9 0.9 0.007 15.5 0.9 1.1 1 0 0 1 1 1 1 Lycopene cyclase protein GIDA PF01134.22 ELR14954.1 - 0.0085 15.2 1.4 0.014 14.5 1.3 1.4 1 1 0 1 1 1 1 Glucose inhibited division protein A Pyr_redox PF00070.27 ELR14954.1 - 0.013 16.0 3.9 0.015 15.9 2.7 1.7 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase TrkA_N PF02254.18 ELR14954.1 - 0.014 15.7 0.3 0.023 14.9 0.3 1.5 1 0 0 1 1 1 0 TrkA-N domain NAD_binding_7 PF13241.6 ELR14954.1 - 0.022 15.2 0.1 0.028 14.9 0.1 1.2 1 0 0 1 1 1 0 Putative NAD(P)-binding UDPG_MGDP_dh_N PF03721.14 ELR14954.1 - 0.024 14.2 0.6 0.027 14.0 0.6 1.3 1 1 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain IlvN PF07991.12 ELR14954.1 - 0.03 13.9 0.1 0.046 13.3 0.1 1.2 1 0 0 1 1 1 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain Shikimate_DH PF01488.20 ELR14954.1 - 0.04 14.0 1.0 0.12 12.4 0.2 1.9 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase Trp_halogenase PF04820.14 ELR14954.1 - 0.048 12.5 1.8 0.053 12.4 1.7 1.2 1 1 0 1 1 1 0 Tryptophan halogenase NAD_Gly3P_dh_N PF01210.23 ELR14954.1 - 0.093 12.7 0.2 0.11 12.4 0.2 1.3 1 1 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus Amino_oxidase PF01593.24 ELR14954.1 - 0.11 11.7 0.1 1.2 8.3 0.1 2.0 2 0 0 2 2 2 0 Flavin containing amine oxidoreductase 3HCDH_N PF02737.18 ELR14954.1 - 0.16 11.8 2.2 0.24 11.3 2.2 1.6 1 1 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Peptidase_M56 PF05569.11 ELR14955.1 - 0.16 11.1 3.8 0.46 9.6 3.8 1.7 1 1 0 1 1 1 0 BlaR1 peptidase M56 p450 PF00067.22 ELR14957.1 - 6.6e-89 298.8 0.0 8.1e-89 298.5 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 DUF3667 PF12412.8 ELR14957.1 - 0.087 12.3 0.1 0.21 11.1 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3667) Yop-YscD_cpl PF16697.5 ELR14958.1 - 4.8e-10 39.6 0.0 4.8e-10 39.6 0.0 4.9 5 0 0 5 5 5 1 Inner membrane component of T3SS, cytoplasmic domain FHA PF00498.26 ELR14958.1 - 2.7e-09 37.2 0.0 1.1e-08 35.3 0.0 2.2 1 0 0 1 1 1 1 FHA domain S4_2 PF13275.6 ELR14958.1 - 0.029 14.2 0.1 0.13 12.1 0.1 2.1 1 0 0 1 1 1 0 S4 domain RA PF00788.23 ELR14959.1 - 4.6e-06 27.2 0.0 8.8e-06 26.3 0.0 1.5 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain zf-CCCH PF00642.24 ELR14960.1 - 9.7e-07 28.6 6.4 0.0031 17.4 0.6 2.7 1 1 1 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Torus PF16131.5 ELR14960.1 - 0.0048 17.6 5.3 0.33 11.7 0.9 2.8 1 1 1 2 2 2 2 Torus domain zf_CCCH_4 PF18345.1 ELR14960.1 - 0.0093 16.0 0.2 0.0093 16.0 0.2 4.4 3 2 0 3 3 3 1 Zinc finger domain zf-C3H1 PF10650.9 ELR14960.1 - 0.016 14.9 4.2 0.59 9.9 0.7 2.7 2 0 0 2 2 2 0 Putative zinc-finger domain LAT PF15234.6 ELR14960.1 - 0.066 12.9 5.4 0.11 12.3 5.4 1.3 1 0 0 1 1 1 0 Linker for activation of T-cells zf-CCCH_3 PF15663.5 ELR14960.1 - 0.12 12.6 6.6 9 6.6 3.9 2.4 1 1 1 2 2 2 0 Zinc-finger containing family SDA1 PF05285.12 ELR14960.1 - 0.58 9.5 13.9 0.8 9.1 13.9 1.1 1 0 0 1 1 1 0 SDA1 RNA_pol_Rpc4 PF05132.14 ELR14960.1 - 0.98 9.8 3.4 1.7 9.1 3.4 1.3 1 0 0 1 1 1 0 RNA polymerase III RPC4 BUD22 PF09073.10 ELR14960.1 - 2 7.7 16.1 2.8 7.2 16.1 1.1 1 0 0 1 1 1 0 BUD22 XRCC4 PF06632.12 ELR14960.1 - 2.8 6.7 8.4 4.1 6.2 8.4 1.1 1 0 0 1 1 1 0 DNA double-strand break repair and V(D)J recombination protein XRCC4 PPP4R2 PF09184.11 ELR14960.1 - 8.9 5.8 13.1 14 5.2 13.1 1.2 1 0 0 1 1 1 0 PPP4R2 DSS1_SEM1 PF05160.13 ELR14961.1 - 7.2e-20 70.8 27.8 8.7e-20 70.5 27.8 1.1 1 0 0 1 1 1 1 DSS1/SEM1 family DUF2947 PF11163.8 ELR14961.1 - 0.0041 17.0 10.3 0.0043 16.9 10.3 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2947) DNA_pol_phi PF04931.13 ELR14961.1 - 1.2 7.1 19.3 1.2 7.2 19.3 1.0 1 0 0 1 1 1 0 DNA polymerase phi Trp_oprn_chp PF09534.10 ELR14962.1 - 0.22 11.3 7.3 0.5 10.1 7.3 1.7 1 1 0 1 1 1 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) PGM_PMM_IV PF00408.20 ELR14964.1 - 7.6e-07 29.2 0.0 1.4e-06 28.4 0.0 1.5 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain Herpes_pp85 PF04637.12 ELR14965.1 - 0.055 11.9 2.8 0.063 11.7 2.8 1.1 1 0 0 1 1 1 0 Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25) AAA_11 PF13086.6 ELR14966.1 - 6.9e-11 42.4 6.7 2.4e-10 40.6 6.7 1.9 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.6 ELR14966.1 - 2.1e-08 34.6 0.0 3.7e-08 33.8 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 ELR14966.1 - 1.5e-06 28.1 0.0 2.6e-06 27.3 0.0 1.3 1 0 0 1 1 1 1 AAA domain UvrD-helicase PF00580.21 ELR14966.1 - 0.00027 20.5 0.4 0.00063 19.4 0.0 1.7 2 0 0 2 2 2 1 UvrD/REP helicase N-terminal domain ResIII PF04851.15 ELR14966.1 - 0.00042 20.3 0.0 0.0011 19.0 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit PhoH PF02562.16 ELR14966.1 - 0.0031 17.0 0.0 0.0066 15.9 0.0 1.5 1 0 0 1 1 1 1 PhoH-like protein DUF2075 PF09848.9 ELR14966.1 - 0.01 15.1 0.0 0.016 14.5 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_16 PF13191.6 ELR14966.1 - 0.016 15.6 1.5 0.062 13.7 1.0 2.2 1 1 0 1 1 1 0 AAA ATPase domain AAA_5 PF07728.14 ELR14966.1 - 0.036 14.1 0.0 0.097 12.7 0.0 1.7 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) DEAD PF00270.29 ELR14966.1 - 0.057 13.2 0.0 0.1 12.3 0.0 1.4 1 0 0 1 1 1 0 DEAD/DEAH box helicase AAA_25 PF13481.6 ELR14966.1 - 0.075 12.6 0.0 0.18 11.3 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 ELR14966.1 - 0.11 12.8 0.0 0.29 11.4 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA PF00004.29 ELR14966.1 - 0.13 12.7 0.0 0.29 11.6 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) BUD22 PF09073.10 ELR14966.1 - 3 7.1 19.6 4.2 6.6 19.6 1.1 1 0 0 1 1 1 0 BUD22 Tub_N PF16322.5 ELR14966.1 - 4.3 7.7 11.9 7.5 6.9 11.9 1.3 1 0 0 1 1 1 0 Tubby N-terminal CDC27 PF09507.10 ELR14966.1 - 8.4 5.7 13.5 12 5.1 13.5 1.1 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Pkinase PF00069.25 ELR14967.1 - 5.7e-64 216.0 0.0 7.1e-64 215.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR14967.1 - 3.1e-45 154.5 0.0 4.5e-45 154.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase PBD PF00786.28 ELR14967.1 - 5.4e-11 42.7 0.0 5.4e-11 42.7 0.0 1.9 2 0 0 2 2 2 1 P21-Rho-binding domain Kinase-like PF14531.6 ELR14967.1 - 0.011 15.1 0.0 0.43 9.8 0.0 2.2 2 0 0 2 2 2 0 Kinase-like Pkinase_fungal PF17667.1 ELR14967.1 - 0.084 11.6 0.0 0.12 11.1 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase APH PF01636.23 ELR14967.1 - 0.15 12.0 0.2 0.87 9.5 0.1 1.9 1 1 1 2 2 2 0 Phosphotransferase enzyme family FYVE PF01363.21 ELR14968.1 - 6e-14 51.9 4.9 1.1e-13 51.1 4.9 1.4 1 0 0 1 1 1 1 FYVE zinc finger Glyco_transf_28 PF03033.20 ELR14968.1 - 5.3e-10 39.5 0.0 9.8e-10 38.6 0.0 1.5 1 0 0 1 1 1 1 Glycosyltransferase family 28 N-terminal domain UDPGT PF00201.18 ELR14968.1 - 8.9e-10 38.0 0.0 1.3e-09 37.5 0.0 1.1 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase FYVE_2 PF02318.16 ELR14968.1 - 6.7e-05 23.1 0.6 0.00011 22.4 0.6 1.4 1 0 0 1 1 1 1 FYVE-type zinc finger Glyco_tran_28_C PF04101.16 ELR14968.1 - 0.00019 21.5 0.0 0.00033 20.7 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain IBR PF01485.21 ELR14968.1 - 0.018 15.3 1.3 0.035 14.3 1.3 1.4 1 0 0 1 1 1 0 IBR domain, a half RING-finger domain zf-RING_5 PF14634.6 ELR14968.1 - 8.5 6.4 9.1 16 5.5 9.1 1.4 1 0 0 1 1 1 0 zinc-RING finger domain AAA PF00004.29 ELR14969.1 - 2e-17 63.9 0.3 6.3e-17 62.2 0.0 2.0 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 ELR14969.1 - 0.00042 20.6 1.5 0.011 16.0 0.1 3.1 2 1 1 3 3 3 1 AAA domain AAA_5 PF07728.14 ELR14969.1 - 0.0038 17.2 0.0 0.0085 16.1 0.0 1.7 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 ELR14969.1 - 0.005 17.2 0.4 0.005 17.2 0.4 2.5 2 1 0 2 2 2 1 AAA ATPase domain AAA_2 PF07724.14 ELR14969.1 - 0.0086 16.2 0.0 0.024 14.7 0.0 1.7 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) Zot PF05707.12 ELR14969.1 - 0.0091 15.7 0.2 0.2 11.3 0.0 2.5 1 1 0 2 2 2 1 Zonular occludens toxin (Zot) Mg_chelatase PF01078.21 ELR14969.1 - 0.056 12.8 0.2 0.21 11.0 0.1 1.9 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI Vps36_ESCRT-II PF11605.8 ELR14969.1 - 0.062 13.5 0.0 0.14 12.4 0.0 1.5 1 0 0 1 1 1 0 Vacuolar protein sorting protein 36 Vps36 MCM_lid PF17855.1 ELR14969.1 - 0.079 13.4 0.0 0.29 11.6 0.0 2.0 1 0 0 1 1 1 0 MCM AAA-lid domain CbiA PF01656.23 ELR14969.1 - 0.11 12.5 0.0 0.24 11.4 0.0 1.6 1 0 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain MetOD2 PF18548.1 ELR14969.1 - 0.24 11.6 3.0 1.1 9.4 0.8 2.8 3 0 0 3 3 3 0 Metanogen output domain 2 DUF16 PF01519.16 ELR14969.1 - 0.73 10.4 6.4 1.3 9.5 3.0 2.8 3 0 0 3 3 3 0 Protein of unknown function DUF16 efThoc1 PF11957.8 ELR14970.1 - 6.2e-72 242.9 0.3 1.8e-71 241.3 0.3 1.7 1 1 0 1 1 1 1 THO complex subunit 1 transcription elongation factor K_trans PF02705.16 ELR14971.1 - 2.8e-175 583.9 16.9 3.5e-175 583.6 16.9 1.1 1 0 0 1 1 1 1 K+ potassium transporter AMP-binding PF00501.28 ELR14971.1 - 9.5e-05 21.2 0.0 0.00017 20.3 0.0 1.3 1 0 0 1 1 1 1 AMP-binding enzyme Ras PF00071.22 ELR14972.1 - 3.1e-59 199.2 0.0 1.3e-37 128.9 0.0 2.2 2 0 0 2 2 2 2 Ras family Kelch_4 PF13418.6 ELR14972.1 - 1.7e-44 149.6 4.7 1.9e-11 43.8 0.0 6.7 6 0 0 6 6 6 6 Galactose oxidase, central domain Kelch_5 PF13854.6 ELR14972.1 - 1.6e-29 101.4 6.9 2e-05 24.5 0.1 7.0 7 0 0 7 7 7 5 Kelch motif Kelch_6 PF13964.6 ELR14972.1 - 9.1e-28 95.6 4.4 1.4e-05 25.2 0.0 6.8 7 0 0 7 7 6 5 Kelch motif Kelch_3 PF13415.6 ELR14972.1 - 1.2e-27 95.6 3.3 2.5e-09 37.2 0.0 7.5 7 0 0 7 7 7 5 Galactose oxidase, central domain Kelch_1 PF01344.25 ELR14972.1 - 2.3e-26 91.1 3.9 1.1e-06 28.2 0.0 6.3 6 0 0 6 6 6 4 Kelch motif Roc PF08477.13 ELR14972.1 - 2.6e-19 69.6 0.0 9.5e-15 54.9 0.0 2.4 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase Kelch_2 PF07646.15 ELR14972.1 - 4.8e-17 61.2 13.8 0.0011 18.9 0.0 6.1 6 0 0 6 6 5 5 Kelch motif F-box-like PF12937.7 ELR14972.1 - 3.8e-10 39.5 0.6 8.2e-10 38.4 0.6 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ELR14972.1 - 0.0013 18.5 0.2 0.0034 17.2 0.2 1.7 1 0 0 1 1 1 1 F-box domain RAG2 PF03089.14 ELR14972.1 - 0.0073 15.3 2.2 11 4.9 0.0 4.2 4 0 0 4 4 4 0 Recombination activating protein 2 SR-25 PF10500.9 ELR14972.1 - 0.0092 15.6 6.7 0.023 14.3 6.7 1.6 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein PA PF02225.22 ELR14972.1 - 0.014 15.4 0.0 13 5.9 0.0 3.1 3 0 0 3 3 3 0 PA domain PTPRCAP PF15713.5 ELR14972.1 - 0.018 15.3 6.0 0.062 13.6 6.0 1.9 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated GAD PF02938.14 ELR14972.1 - 0.061 13.6 0.0 19 5.5 0.0 2.4 2 0 0 2 2 2 0 GAD domain NARP1 PF12569.8 ELR14972.1 - 0.57 9.0 7.0 0.91 8.4 7.0 1.2 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 DUF4820 PF16091.5 ELR14972.1 - 1.4 8.2 3.2 0.96 8.8 1.3 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4820) Striatin PF08232.12 ELR14972.1 - 6.6 7.3 11.1 22 5.6 0.4 2.5 2 0 0 2 2 2 0 Striatin family Gelsolin PF00626.22 ELR14973.1 - 1.7e-39 133.5 18.1 1.9e-09 37.3 0.0 7.1 7 0 0 7 7 7 5 Gelsolin repeat VHP PF02209.19 ELR14973.1 - 3.9e-15 55.6 1.3 3.9e-15 55.6 1.3 3.6 3 0 0 3 3 3 1 Villin headpiece domain PH PF00169.29 ELR14973.1 - 0.00086 19.8 0.1 0.012 16.1 0.0 3.1 3 0 0 3 3 3 1 PH domain DZR PF12773.7 ELR14973.1 - 0.02 14.9 0.6 0.052 13.6 0.6 1.6 1 0 0 1 1 1 0 Double zinc ribbon Nudix_N_2 PF14803.6 ELR14973.1 - 1 9.3 3.0 19 5.2 0.4 3.2 2 0 0 2 2 2 0 Nudix N-terminal Na_sulph_symp PF00939.19 ELR14974.1 - 2.2e-23 83.1 7.5 1.7e-20 73.6 1.5 2.7 1 1 1 2 2 2 2 Sodium:sulfate symporter transmembrane region CitMHS PF03600.16 ELR14974.1 - 3.3e-10 39.6 16.6 1.2e-05 24.7 2.8 3.0 2 1 1 3 3 3 3 Citrate transporter Cytomega_UL20A PF05984.12 ELR14974.1 - 0.76 10.1 4.5 1.6 9.1 1.8 2.2 2 0 0 2 2 2 0 Cytomegalovirus UL20A protein DUF2207 PF09972.9 ELR14974.1 - 6.4 5.4 5.3 0.49 9.1 0.3 1.6 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) BUD22 PF09073.10 ELR14975.1 - 0.00053 19.4 7.6 0.00068 19.1 7.6 1.1 1 0 0 1 1 1 1 BUD22 YL1 PF05764.13 ELR14975.1 - 0.24 11.5 21.5 0.16 12.1 10.6 2.1 2 0 0 2 2 2 0 YL1 nuclear protein PIP49_N PF14875.6 ELR14975.1 - 0.27 11.1 2.6 0.47 10.3 2.6 1.3 1 0 0 1 1 1 0 N-term cysteine-rich ER, FAM69 DUF3439 PF11921.8 ELR14975.1 - 0.33 10.9 10.8 0.73 9.8 10.8 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) DUF913 PF06025.12 ELR14975.1 - 0.38 9.7 7.2 2.9 6.8 1.3 2.1 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) CPSF100_C PF13299.6 ELR14975.1 - 0.87 9.7 7.0 1.2 9.3 1.1 2.2 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal SSP160 PF06933.11 ELR14975.1 - 0.9 7.7 11.7 1.2 7.2 11.7 1.2 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 RP-C_C PF11800.8 ELR14975.1 - 1.3 9.0 7.5 3.4 7.7 1.8 2.1 2 0 0 2 2 2 0 Replication protein C C-terminal region Host_attach PF10116.9 ELR14975.1 - 2 9.0 7.2 1.5 9.4 0.1 2.2 2 0 0 2 2 2 0 Protein required for attachment to host cells PGA2 PF07543.12 ELR14975.1 - 2.3 8.2 17.1 0.53 10.3 7.8 2.2 2 0 0 2 2 2 0 Protein trafficking PGA2 TLP-20 PF06088.11 ELR14975.1 - 3.2 7.6 7.1 1.8 8.4 3.8 1.9 2 0 0 2 2 2 0 Nucleopolyhedrovirus telokin-like protein-20 (TLP20) DUF4611 PF15387.6 ELR14975.1 - 5.1 7.4 14.7 1.3 9.3 8.5 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4611) DNA_pol_phi PF04931.13 ELR14975.1 - 5.2 5.1 23.3 0.96 7.5 17.7 1.9 2 0 0 2 2 2 0 DNA polymerase phi Cwf_Cwc_15 PF04889.12 ELR14975.1 - 8.3 6.1 22.0 3.5 7.3 14.9 2.2 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein PQ-loop PF04193.14 ELR14976.1 - 5.9e-16 58.0 19.8 5.9e-09 35.6 1.6 3.1 3 0 0 3 3 3 2 PQ loop repeat ST7 PF04184.12 ELR14976.1 - 0.013 14.0 0.7 0.35 9.3 0.2 2.0 2 0 0 2 2 2 0 ST7 protein BCD PF15461.6 ELR14976.1 - 0.014 14.9 1.4 0.014 14.9 1.4 2.3 1 1 1 2 2 2 0 Beta-carotene 15,15'-dioxygenase CCT PF06203.14 ELR14977.1 - 0.0036 17.3 2.6 0.0094 16.0 2.6 1.7 1 0 0 1 1 1 1 CCT motif Peptidase_M16 PF00675.20 ELR14977.1 - 0.095 12.7 0.4 0.19 11.7 0.4 1.6 1 0 0 1 1 1 0 Insulinase (Peptidase family M16) GTP-bdg_M PF16360.5 ELR14977.1 - 3.4 8.3 10.4 10 6.8 0.0 3.7 4 1 0 4 4 4 0 GTP-binding GTPase Middle Region PP2C PF00481.21 ELR14978.1 - 2.7e-54 184.5 0.1 3e-54 184.4 0.1 1.0 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C_2 PF13672.6 ELR14978.1 - 1.1e-05 25.1 0.4 1.1e-05 25.1 0.4 1.5 2 0 0 2 2 2 1 Protein phosphatase 2C SpoIIE PF07228.12 ELR14978.1 - 0.063 13.2 0.0 0.13 12.1 0.0 1.5 1 0 0 1 1 1 0 Stage II sporulation protein E (SpoIIE) SSXT PF05030.12 ELR14980.1 - 1.4e-17 63.1 2.0 4.9e-17 61.3 0.1 2.9 2 1 0 2 2 2 1 SSXT protein (N-terminal region) Myb_DNA-binding PF00249.31 ELR14980.1 - 1.4e-05 25.1 0.0 2.3e-05 24.5 0.0 1.3 1 0 0 1 1 1 1 Myb-like DNA-binding domain Elf4 PF07011.11 ELR14980.1 - 0.013 15.4 0.3 0.037 13.9 0.3 1.7 1 0 0 1 1 1 0 Early Flowering 4 domain POR_N PF01855.19 ELR14981.1 - 9.5e-73 244.7 0.2 1.5e-72 244.1 0.2 1.3 1 0 0 1 1 1 1 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg POR PF01558.18 ELR14981.1 - 1.6e-29 103.3 0.1 2.7e-29 102.5 0.1 1.4 1 0 0 1 1 1 1 Pyruvate ferredoxin/flavodoxin oxidoreductase EKR PF10371.9 ELR14981.1 - 1.4e-17 63.2 0.0 3.8e-17 61.8 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function PFOR_II PF17147.4 ELR14981.1 - 3.2e-15 56.3 0.0 8.3e-15 54.9 0.0 1.7 1 0 0 1 1 1 1 Pyruvate:ferredoxin oxidoreductase core domain II Fer4_7 PF12838.7 ELR14981.1 - 0.00011 22.7 1.0 0.00011 22.7 1.0 1.9 2 0 0 2 2 1 1 4Fe-4S dicluster domain Fer4_10 PF13237.6 ELR14981.1 - 0.00014 21.9 1.2 0.00014 21.9 1.2 1.7 2 0 0 2 2 1 1 4Fe-4S dicluster domain Fer4 PF00037.27 ELR14981.1 - 0.00019 21.1 0.7 0.00019 21.1 0.7 2.8 3 0 0 3 3 3 1 4Fe-4S binding domain Fer4_16 PF13484.6 ELR14981.1 - 0.00029 21.7 1.4 0.00075 20.4 1.4 1.7 1 0 0 1 1 1 1 4Fe-4S double cluster binding domain Fer4_21 PF14697.6 ELR14981.1 - 0.0014 18.7 2.1 0.013 15.6 0.9 2.5 2 0 0 2 2 2 1 4Fe-4S dicluster domain Fer4_6 PF12837.7 ELR14981.1 - 0.0063 16.5 1.5 0.0063 16.5 1.5 2.4 3 0 0 3 3 3 1 4Fe-4S binding domain Fer4_2 PF12797.7 ELR14981.1 - 0.013 15.6 3.5 0.013 15.6 3.5 2.8 3 0 0 3 3 3 0 4Fe-4S binding domain Transketolase_C PF02780.20 ELR14981.1 - 0.013 15.4 0.0 0.036 13.9 0.0 1.7 1 0 0 1 1 1 0 Transketolase, C-terminal domain Fer4_9 PF13187.6 ELR14981.1 - 0.014 15.5 1.5 0.014 15.5 1.5 2.0 2 0 0 2 2 2 0 4Fe-4S dicluster domain Fer4_8 PF13183.6 ELR14981.1 - 0.055 13.9 0.7 0.17 12.4 0.7 1.9 1 0 0 1 1 1 0 4Fe-4S dicluster domain Fer4_17 PF13534.6 ELR14981.1 - 0.063 13.8 0.4 0.063 13.8 0.4 1.9 2 0 0 2 2 1 0 4Fe-4S dicluster domain ABC_tran PF00005.27 ELR14982.1 - 3e-46 157.3 0.0 9.6e-29 100.6 0.0 2.5 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 ELR14982.1 - 5.4e-32 111.5 2.9 7.1e-32 111.1 2.9 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region SMC_N PF02463.19 ELR14982.1 - 1.4e-11 44.2 1.0 0.018 14.5 0.0 4.2 2 2 1 4 4 4 3 RecF/RecN/SMC N terminal domain MMR_HSR1 PF01926.23 ELR14982.1 - 1.3e-08 34.9 0.2 0.00047 20.2 0.0 3.2 3 0 0 3 3 3 2 50S ribosome-binding GTPase Dynamin_N PF00350.23 ELR14982.1 - 2.8e-07 30.7 0.4 0.057 13.5 0.2 3.3 3 0 0 3 3 3 2 Dynamin family AAA_16 PF13191.6 ELR14982.1 - 4.2e-07 30.5 0.8 0.032 14.6 0.4 2.9 2 1 0 2 2 2 2 AAA ATPase domain RsgA_GTPase PF03193.16 ELR14982.1 - 4.6e-07 29.9 0.2 0.042 13.8 0.0 2.5 2 0 0 2 2 2 2 RsgA GTPase AAA_23 PF13476.6 ELR14982.1 - 9.7e-06 26.2 0.2 0.12 12.9 0.0 2.5 2 1 0 2 2 2 2 AAA domain T2SSE PF00437.20 ELR14982.1 - 2.8e-05 23.3 0.0 0.18 10.9 0.0 2.4 2 0 0 2 2 2 2 Type II/IV secretion system protein AAA_29 PF13555.6 ELR14982.1 - 4.7e-05 23.1 0.1 0.18 11.5 0.0 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_22 PF13401.6 ELR14982.1 - 6.1e-05 23.3 1.3 2.1 8.6 0.1 3.4 3 0 0 3 3 3 2 AAA domain AAA_7 PF12775.7 ELR14982.1 - 9.6e-05 22.0 0.3 0.29 10.6 0.0 2.4 2 0 0 2 2 2 2 P-loop containing dynein motor region AAA_21 PF13304.6 ELR14982.1 - 0.00013 21.9 0.2 1.2 8.9 0.0 3.5 3 0 0 3 3 3 1 AAA domain, putative AbiEii toxin, Type IV TA system cobW PF02492.19 ELR14982.1 - 0.00056 19.6 0.2 0.14 11.7 0.1 2.6 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain SbcCD_C PF13558.6 ELR14982.1 - 0.0013 18.9 0.0 3.1 8.1 0.0 2.8 2 0 0 2 2 2 2 Putative exonuclease SbcCD, C subunit AAA_30 PF13604.6 ELR14982.1 - 0.0015 18.3 1.1 1.6 8.4 0.1 3.2 3 0 0 3 3 3 1 AAA domain Roc PF08477.13 ELR14982.1 - 0.0036 17.5 0.1 4.1 7.7 0.0 2.7 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase FtsK_SpoIIIE PF01580.18 ELR14982.1 - 0.0043 16.5 0.0 0.7 9.2 0.0 2.4 2 0 0 2 2 2 1 FtsK/SpoIIIE family TrwB_AAD_bind PF10412.9 ELR14982.1 - 0.0046 15.9 1.4 0.37 9.6 0.2 2.5 2 0 0 2 2 2 1 Type IV secretion-system coupling protein DNA-binding domain IIGP PF05049.13 ELR14982.1 - 0.012 14.8 0.2 0.041 12.9 0.0 1.8 2 0 0 2 2 2 0 Interferon-inducible GTPase (IIGP) Zeta_toxin PF06414.12 ELR14982.1 - 0.016 14.5 0.3 2.7 7.2 0.0 2.4 2 0 0 2 2 2 0 Zeta toxin DUF87 PF01935.17 ELR14982.1 - 0.018 15.2 0.8 0.32 11.1 0.1 2.3 2 0 0 2 2 2 0 Helicase HerA, central domain IstB_IS21 PF01695.17 ELR14982.1 - 0.02 14.6 0.2 17 5.1 0.0 3.2 3 0 0 3 3 3 0 IstB-like ATP binding protein Septin PF00735.18 ELR14982.1 - 0.025 13.9 0.0 1.8 7.8 0.0 2.2 2 0 0 2 2 2 0 Septin AAA PF00004.29 ELR14982.1 - 0.028 14.8 0.2 5.3 7.5 0.0 3.2 3 0 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) KAP_NTPase PF07693.14 ELR14982.1 - 0.06 12.6 0.0 4 6.6 0.0 2.3 2 0 0 2 2 2 0 KAP family P-loop domain AAA_24 PF13479.6 ELR14982.1 - 0.061 13.0 0.1 8.4 6.1 0.0 2.6 2 0 0 2 2 2 0 AAA domain AAA_19 PF13245.6 ELR14982.1 - 0.081 13.3 0.2 0.62 10.4 0.1 2.5 2 0 0 2 2 2 0 AAA domain TsaE PF02367.17 ELR14982.1 - 0.095 12.7 0.2 3.7 7.6 0.1 2.4 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AIG1 PF04548.16 ELR14982.1 - 0.097 12.0 0.4 2.4 7.4 0.1 2.4 2 0 0 2 2 2 0 AIG1 family ATP_bind_1 PF03029.17 ELR14982.1 - 0.1 12.4 0.1 10 5.8 0.1 2.4 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein ABC_membrane PF00664.23 ELR14983.1 - 2.5e-07 30.6 0.9 3.2e-07 30.3 0.9 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region Glyco_trans_1_4 PF13692.6 ELR14984.1 - 5.1e-09 36.7 0.0 8.6e-09 35.9 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glycos_transf_1 PF00534.20 ELR14984.1 - 2.5e-05 23.9 0.0 4.9e-05 22.9 0.0 1.5 1 1 0 1 1 1 1 Glycosyl transferases group 1 Usp PF00582.26 ELR14985.1 - 1.6e-28 100.0 0.1 1.9e-28 99.8 0.1 1.0 1 0 0 1 1 1 1 Universal stress protein family PCP_red PF08369.10 ELR14985.1 - 0.082 13.1 0.6 0.38 11.0 0.3 2.1 2 0 0 2 2 2 0 Proto-chlorophyllide reductase 57 kD subunit U-box PF04564.15 ELR14986.1 - 2.5e-08 33.9 0.0 4.3e-08 33.2 0.0 1.4 1 0 0 1 1 1 1 U-box domain zf-Nse PF11789.8 ELR14986.1 - 2.2e-07 30.6 0.2 5.4e-07 29.3 0.2 1.6 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-C3HC4_2 PF13923.6 ELR14986.1 - 7.8e-06 25.6 0.1 7.8e-06 25.6 0.1 3.4 4 1 1 5 5 5 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 ELR14986.1 - 1e-05 25.7 0.1 1e-05 25.7 0.1 3.9 3 1 0 3 3 3 1 Ring finger domain zf-ANAPC11 PF12861.7 ELR14986.1 - 0.00021 21.3 0.1 0.00021 21.3 0.1 3.2 3 0 0 3 3 3 1 Anaphase-promoting complex subunit 11 RING-H2 finger DUF4131 PF13567.6 ELR14986.1 - 0.019 14.6 0.8 0.037 13.7 0.8 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) Corona_nucleoca PF00937.18 ELR14986.1 - 0.55 9.2 10.1 0.92 8.5 10.1 1.3 1 0 0 1 1 1 0 Coronavirus nucleocapsid protein Prp18 PF02840.15 ELR14987.1 - 3e-12 46.8 1.8 8.7e-12 45.3 0.0 2.6 3 0 0 3 3 3 1 Prp18 domain TetR_C_31 PF17940.1 ELR14987.1 - 0.0013 18.9 0.7 0.019 15.1 0.1 2.5 1 1 1 2 2 2 1 Tetracyclin repressor-like, C-terminal domain PDDEXK_2 PF12784.7 ELR14987.1 - 0.12 11.9 2.3 0.21 11.1 2.3 1.4 1 0 0 1 1 1 0 PD-(D/E)XK nuclease family transposase DPBB_1 PF03330.18 ELR14988.1 - 3.2e-11 43.3 0.1 5.9e-11 42.5 0.1 1.5 1 1 0 1 1 1 1 Lytic transglycolase Barwin PF00967.17 ELR14988.1 - 0.076 12.9 0.0 0.14 12.0 0.0 1.4 1 1 0 1 1 1 0 Barwin family DUF758 PF05527.11 ELR14989.1 - 2.4e-13 50.5 0.0 4.4e-13 49.6 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF758) PH PF00169.29 ELR14989.1 - 7.1e-10 39.3 0.0 1.3e-09 38.5 0.0 1.4 1 0 0 1 1 1 1 PH domain DUF3458_C PF17432.2 ELR14989.1 - 0.042 13.2 0.2 0.064 12.6 0.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3458_C) ARM repeats PH_8 PF15409.6 ELR14989.1 - 0.15 12.4 0.0 0.36 11.2 0.0 1.7 1 0 0 1 1 1 0 Pleckstrin homology domain PfkB PF00294.24 ELR14990.1 - 3.1e-36 125.2 0.2 3.9e-27 95.4 0.1 2.0 1 1 1 2 2 2 2 pfkB family carbohydrate kinase Carb_kinase PF01256.17 ELR14990.1 - 0.099 12.1 0.0 0.18 11.2 0.0 1.4 1 0 0 1 1 1 0 Carbohydrate kinase Metallophos_2 PF12850.7 ELR14991.1 - 9.3e-07 29.2 0.2 0.0052 17.0 0.0 2.4 2 0 0 2 2 2 2 Calcineurin-like phosphoesterase superfamily domain Metallophos PF00149.28 ELR14991.1 - 0.00019 22.0 5.9 0.002 18.6 5.9 2.1 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Myc_N PF01056.18 ELR14991.1 - 4.8 7.0 10.6 0.84 9.5 6.8 1.6 2 0 0 2 2 2 0 Myc amino-terminal region Metallophos PF00149.28 ELR14992.1 - 7.7e-07 29.8 2.9 3.1e-06 27.8 2.9 1.8 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 ELR14992.1 - 2e-06 28.1 0.1 0.0031 17.7 0.0 2.2 2 0 0 2 2 2 2 Calcineurin-like phosphoesterase superfamily domain Ras PF00071.22 ELR14993.1 - 1.7e-27 96.0 0.0 1.2e-25 90.0 0.0 2.8 1 1 0 1 1 1 1 Ras family Roc PF08477.13 ELR14993.1 - 2.1e-19 69.9 0.0 3.6e-18 65.9 0.0 2.2 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR14993.1 - 9.3e-08 31.7 0.0 9.4e-07 28.4 0.0 2.1 2 0 0 2 2 2 1 ADP-ribosylation factor family MqsR_toxin PF15723.5 ELR14994.1 - 0.07 13.5 0.0 2.5 8.5 0.0 2.6 2 0 0 2 2 2 0 Motility quorum-sensing regulator, toxin of MqsA Glyco_hydro_53 PF07745.13 ELR14995.1 - 0.091 11.7 0.2 0.16 10.9 0.2 1.3 1 0 0 1 1 1 0 Glycosyl hydrolase family 53 Ras PF00071.22 ELR14996.1 - 5.4e-31 107.4 0.0 2.8e-28 98.5 0.0 2.2 1 1 0 1 1 1 1 Ras family Roc PF08477.13 ELR14996.1 - 2.5e-18 66.4 0.0 2.1e-17 63.5 0.0 2.3 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase GRDP-like PF07173.12 ELR14996.1 - 1.7e-17 64.4 0.0 3.5e-08 34.2 0.0 2.8 1 1 1 2 2 2 2 Glycine-rich domain-containing protein-like Arf PF00025.21 ELR14996.1 - 3.1e-07 30.0 0.0 4.5e-06 26.2 0.0 2.1 2 0 0 2 2 2 1 ADP-ribosylation factor family DEAD PF00270.29 ELR14997.1 - 2.7e-36 125.0 0.2 3.2e-36 124.7 0.2 1.1 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_19 PF13245.6 ELR14997.1 - 4.7e-05 23.8 0.6 6.9e-05 23.2 0.6 1.4 1 1 0 1 1 1 1 AAA domain ResIII PF04851.15 ELR14997.1 - 6.8e-05 22.9 0.0 9.1e-05 22.5 0.0 1.1 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_30 PF13604.6 ELR14997.1 - 0.00023 21.0 0.4 0.00031 20.5 0.4 1.2 1 0 0 1 1 1 1 AAA domain UvrD-helicase PF00580.21 ELR14997.1 - 0.0026 17.3 0.2 0.0029 17.2 0.2 1.4 1 1 0 1 1 1 1 UvrD/REP helicase N-terminal domain CobA_CobO_BtuR PF02572.15 ELR14997.1 - 0.0031 17.8 0.3 0.0053 17.0 0.3 1.4 1 1 0 1 1 1 1 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP TniB PF05621.11 ELR14997.1 - 0.012 15.0 0.1 0.021 14.3 0.1 1.5 1 0 0 1 1 1 0 Bacterial TniB protein RUN PF02759.19 ELR14998.1 - 1.1e-13 51.3 0.3 1.3e-12 47.8 0.0 2.9 2 0 0 2 2 2 1 RUN domain Hamartin PF04388.12 ELR14999.1 - 0.3 9.7 17.2 0.34 9.5 17.2 1.0 1 0 0 1 1 1 0 Hamartin protein SMYLE_N PF18615.1 ELR14999.1 - 2 7.9 11.6 2.2 7.8 11.6 1.1 1 0 0 1 1 1 0 Short myomegalin-like EB1 binding proteins, N-terminal domain Presenilin PF01080.17 ELR14999.1 - 2.2 6.9 16.6 2.5 6.8 16.6 1.1 1 0 0 1 1 1 0 Presenilin Zip PF02535.22 ELR14999.1 - 4.4 6.4 13.0 4.9 6.3 13.0 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Use1 PF09753.9 ELR14999.1 - 4.8 6.8 11.8 6.4 6.4 11.8 1.2 1 0 0 1 1 1 0 Membrane fusion protein Use1 TMEM174 PF15029.6 ELR14999.1 - 8.6 6.0 8.1 14 5.3 8.1 1.5 1 1 0 1 1 1 0 Transmembrane protein 174 RR_TM4-6 PF06459.12 ELR14999.1 - 9.1 6.0 16.3 11 5.8 16.3 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Pkinase PF00069.25 ELR15000.1 - 1.4e-33 116.4 4.7 1e-29 103.8 0.8 4.4 2 1 1 3 3 3 2 Protein kinase domain Pkinase_Tyr PF07714.17 ELR15000.1 - 4.4e-12 45.8 0.3 1.1e-05 24.9 0.0 3.6 2 1 1 3 3 3 2 Protein tyrosine kinase GTP1_OBG PF01018.22 ELR15000.1 - 0.0038 16.8 0.4 0.0062 16.1 0.4 1.3 1 0 0 1 1 1 1 GTP1/OBG APH PF01636.23 ELR15000.1 - 0.0078 16.2 0.1 0.017 15.1 0.1 1.5 1 1 0 1 1 1 1 Phosphotransferase enzyme family Kinase-like PF14531.6 ELR15000.1 - 0.072 12.4 0.0 0.55 9.5 0.0 2.0 2 0 0 2 2 2 0 Kinase-like TPR_12 PF13424.6 ELR15002.1 - 3.1e-27 94.6 11.2 5.2e-10 39.5 0.8 6.1 4 2 2 6 6 6 4 Tetratricopeptide repeat TPR_10 PF13374.6 ELR15002.1 - 1.5e-16 59.7 12.0 0.00027 20.7 0.2 7.5 8 0 0 8 8 8 4 Tetratricopeptide repeat TPR_7 PF13176.6 ELR15002.1 - 1.2e-08 34.4 0.2 0.05 13.7 0.0 4.8 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_2 PF07719.17 ELR15002.1 - 6.3e-08 32.2 4.3 0.035 14.2 0.6 5.5 6 0 0 6 6 5 2 Tetratricopeptide repeat TPR_1 PF00515.28 ELR15002.1 - 3.6e-06 26.5 0.3 0.47 10.4 0.0 5.2 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_16 PF13432.6 ELR15002.1 - 3.8e-05 24.2 4.5 0.0051 17.4 0.1 4.1 5 0 0 5 5 4 1 Tetratricopeptide repeat TPR_14 PF13428.6 ELR15002.1 - 4.1e-05 24.1 11.8 1.2 10.1 0.0 5.5 6 1 1 7 7 4 2 Tetratricopeptide repeat TPR_MalT PF17874.1 ELR15002.1 - 8e-05 22.2 0.4 0.29 10.4 0.1 2.6 2 1 0 2 2 2 2 MalT-like TPR region TPR_8 PF13181.6 ELR15002.1 - 0.00013 21.9 0.2 2.8 8.4 0.1 4.2 5 0 0 5 5 5 2 Tetratricopeptide repeat Glyco_hydro_46 PF01374.18 ELR15002.1 - 0.0023 17.6 0.1 0.0054 16.4 0.1 1.6 1 0 0 1 1 1 1 Glycosyl hydrolase family 46 TPR_19 PF14559.6 ELR15002.1 - 0.029 14.9 4.5 0.038 14.5 0.1 3.3 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_4 PF07721.14 ELR15002.1 - 0.17 12.6 18.1 11 7.0 0.9 5.5 5 1 0 5 5 5 0 Tetratricopeptide repeat Sec8_exocyst PF04048.14 ELR15002.1 - 0.18 11.7 1.7 0.61 10.0 0.3 2.4 3 0 0 3 3 3 0 Sec8 exocyst complex component specific domain RhoGEF PF00621.20 ELR15003.1 - 7.1e-48 163.3 0.5 1.1e-47 162.6 0.5 1.3 1 0 0 1 1 1 1 RhoGEF domain PH_13 PF16652.5 ELR15003.1 - 0.0066 16.3 0.0 0.024 14.4 0.0 1.9 2 0 0 2 2 2 1 Pleckstrin homology domain DUF4248 PF14053.6 ELR15003.1 - 0.044 13.8 0.5 0.14 12.2 0.5 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4248) RhoGEF PF00621.20 ELR15004.1 - 0.006 16.8 0.0 0.0072 16.6 0.0 1.1 1 0 0 1 1 1 1 RhoGEF domain Ribosomal_60s PF00428.19 ELR15005.1 - 0.03 14.9 7.5 0.045 14.3 7.5 1.2 1 0 0 1 1 1 0 60s Acidic ribosomal protein CENP-X PF09415.10 ELR15005.1 - 0.059 13.7 0.2 0.084 13.2 0.2 1.2 1 0 0 1 1 1 0 CENP-S associating Centromere protein X TFIIS_C PF01096.18 ELR15006.1 - 1.7e-17 63.0 1.4 1.7e-17 63.0 1.4 2.7 3 0 0 3 3 3 1 Transcription factor S-II (TFIIS) DNA_RNApol_7kD PF03604.13 ELR15006.1 - 0.0081 15.8 10.5 0.045 13.4 1.1 3.4 3 0 0 3 3 3 1 DNA directed RNA polymerase, 7 kDa subunit DZR PF12773.7 ELR15006.1 - 0.0089 16.0 13.3 0.76 9.9 0.6 3.3 1 1 0 2 2 2 1 Double zinc ribbon Zn_Tnp_IS1595 PF12760.7 ELR15006.1 - 0.0099 15.8 6.9 0.01 15.8 0.5 2.4 2 0 0 2 2 2 1 Transposase zinc-ribbon domain SspN PF08177.11 ELR15006.1 - 0.01 15.8 0.2 0.022 14.7 0.2 1.6 1 0 0 1 1 1 0 Small acid-soluble spore protein N family DUF5637 PF18687.1 ELR15006.1 - 0.045 13.7 4.7 0.045 13.7 4.7 2.3 2 1 0 2 2 2 0 Family of unknown function (DUF5637) DUF2387 PF09526.10 ELR15006.1 - 0.046 13.9 2.7 0.26 11.5 0.2 2.5 1 1 1 2 2 2 0 Probable metal-binding protein (DUF2387) Actin_micro PF17003.5 ELR15006.1 - 0.07 12.3 2.5 0.085 12.0 2.5 1.3 1 1 0 1 1 1 0 Putative actin-like family GFA PF04828.14 ELR15006.1 - 0.089 13.1 7.4 0.14 12.5 0.1 3.0 1 1 0 2 2 2 0 Glutathione-dependent formaldehyde-activating enzyme XAF1_C PF18608.1 ELR15006.1 - 0.11 12.0 2.4 0.17 11.5 0.3 2.4 2 0 0 2 2 2 0 XIAP-associated factor 1 C-terminal domain zf-ribbon_3 PF13248.6 ELR15006.1 - 0.26 10.8 19.7 1.3 8.6 0.8 3.7 3 1 1 4 4 4 0 zinc-ribbon domain RNA_POL_M_15KD PF02150.16 ELR15006.1 - 0.27 11.1 15.8 1.2 9.0 0.1 3.3 3 0 0 3 3 3 0 RNA polymerases M/15 Kd subunit C1_1 PF00130.22 ELR15006.1 - 0.34 10.8 8.3 0.098 12.6 1.0 2.4 2 1 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf_UBZ PF18439.1 ELR15006.1 - 0.38 10.4 0.1 0.38 10.4 0.1 3.6 4 0 0 4 4 4 0 Ubiquitin-Binding Zinc Finger OrfB_Zn_ribbon PF07282.11 ELR15006.1 - 0.41 10.6 9.9 0.28 11.1 1.2 2.7 2 1 0 2 2 2 0 Putative transposase DNA-binding domain ADK_lid PF05191.14 ELR15006.1 - 0.73 9.9 0.1 0.73 9.9 0.1 2.8 2 1 0 2 2 1 0 Adenylate kinase, active site lid zf-IS66 PF13005.7 ELR15006.1 - 0.96 9.9 7.1 11 6.5 0.1 3.3 2 1 1 3 3 3 0 zinc-finger binding domain of transposase IS66 HypA PF01155.19 ELR15006.1 - 2.2 8.4 10.1 5 7.2 1.8 2.8 1 1 2 3 3 3 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-H2C2_2 PF13465.6 ELR15006.1 - 8.5 7.0 11.4 1.1 9.8 0.7 3.4 4 0 0 4 4 4 0 Zinc-finger double domain zf-Mss51 PF13824.6 ELR15006.1 - 9 6.5 11.7 28 4.9 2.9 3.4 2 2 1 3 3 3 0 Zinc-finger of mitochondrial splicing suppressor 51 CCDC53 PF10152.9 ELR15008.1 - 0.68 10.3 5.2 0.15 12.5 1.2 1.7 1 1 1 2 2 2 0 Subunit CCDC53 of WASH complex DUF4073 PF13285.6 ELR15010.1 - 0.044 13.4 0.5 0.052 13.2 0.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4073) PSD5 PF07637.11 ELR15011.1 - 0.038 14.3 0.1 0.35 11.2 0.0 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF1595) MRI PF15325.6 ELR15013.1 - 1.9 9.6 6.0 2.5 9.3 6.0 1.2 1 0 0 1 1 1 0 Modulator of retrovirus infection Dicty_REP PF05086.12 ELR15014.1 - 6.6 4.6 6.6 7.4 4.4 6.6 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein HEAT PF02985.22 ELR15015.1 - 2.3e-09 36.7 10.3 0.00026 21.0 0.4 6.8 7 0 0 7 7 7 2 HEAT repeat LisH PF08513.11 ELR15015.1 - 7.7e-06 25.7 0.4 0.0012 18.7 0.0 2.7 2 0 0 2 2 2 1 LisH YabA PF06156.13 ELR15015.1 - 0.00051 20.6 1.0 2 9.1 0.3 3.0 2 0 0 2 2 2 2 Initiation control protein YabA HEAT_2 PF13646.6 ELR15015.1 - 0.0021 18.4 9.2 0.038 14.4 0.1 4.7 5 1 1 6 6 6 2 HEAT repeats HEAT_EZ PF13513.6 ELR15015.1 - 0.0092 16.5 0.7 5.7 7.6 0.2 3.9 2 0 0 2 2 2 1 HEAT-like repeat DivIC PF04977.15 ELR15015.1 - 0.073 12.9 10.2 1.6 8.6 1.7 2.6 2 0 0 2 2 2 0 Septum formation initiator Tti2 PF10521.9 ELR15015.1 - 0.096 12.2 1.0 6.8 6.1 0.1 3.6 4 0 0 4 4 4 0 Tti2 family DUF4201 PF13870.6 ELR15015.1 - 0.17 11.6 7.9 0.29 10.9 1.2 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4201) SlyX PF04102.12 ELR15015.1 - 0.18 12.5 7.9 0.34 11.6 0.9 3.4 3 0 0 3 3 2 0 SlyX ZapB PF06005.12 ELR15015.1 - 3.7 8.1 17.1 0.069 13.6 3.1 3.2 3 0 0 3 3 3 0 Cell division protein ZapB HAUS6_N PF14661.6 ELR15015.1 - 9.8 5.7 12.5 1.5 8.4 4.2 2.9 2 1 0 3 3 3 0 HAUS augmin-like complex subunit 6 N-terminus Hydrolase_4 PF12146.8 ELR15018.1 - 3.8e-07 29.6 0.1 0.00038 19.8 0.1 2.3 2 0 0 2 2 2 2 Serine aminopeptidase, S33 AXE1 PF05448.12 ELR15018.1 - 0.00093 18.0 0.2 0.18 10.4 0.0 2.8 2 1 1 3 3 3 2 Acetyl xylan esterase (AXE1) Peptidase_S9 PF00326.21 ELR15018.1 - 0.0066 15.9 0.8 3.6 7.0 0.0 2.7 3 0 0 3 3 3 2 Prolyl oligopeptidase family DUF818 PF05677.12 ELR15018.1 - 0.02 13.9 0.0 0.031 13.3 0.0 1.2 1 0 0 1 1 1 0 Chlamydia CHLPS protein (DUF818) DUF1057 PF06342.12 ELR15018.1 - 0.22 10.5 0.0 0.4 9.7 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF1057) DAGK_cat PF00781.24 ELR15019.1 - 3.7e-26 91.2 0.0 6.2e-26 90.5 0.0 1.4 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain NAD_kinase PF01513.21 ELR15019.1 - 0.063 12.5 0.1 0.14 11.3 0.0 1.6 2 0 0 2 2 2 0 ATP-NAD kinase DUF1155 PF06633.11 ELR15019.1 - 0.21 11.1 0.5 0.85 9.2 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1155) LRR_4 PF12799.7 ELR15021.1 - 0.00091 19.6 2.4 1.5 9.3 0.5 4.9 4 1 1 5 5 5 2 Leucine Rich repeats (2 copies) Mito_fiss_reg PF05308.11 ELR15021.1 - 0.16 12.0 9.0 0.26 11.3 9.0 1.2 1 0 0 1 1 1 0 Mitochondrial fission regulator CAP_N PF01213.19 ELR15021.1 - 0.23 10.9 10.8 0.36 10.3 10.8 1.2 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal PRIMA1 PF16101.5 ELR15021.1 - 0.47 10.5 9.5 1.2 9.2 9.5 1.6 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 TCP PF03634.13 ELR15022.1 - 0.006 17.2 5.0 0.006 17.2 5.0 3.2 4 0 0 4 4 4 2 TCP family transcription factor Vfa1 PF08432.10 ELR15022.1 - 0.24 11.7 15.4 0.72 10.2 5.2 2.4 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 U1snRNP70_N PF12220.8 ELR15022.1 - 9.8 6.9 18.0 12 6.7 9.8 2.7 2 0 0 2 2 2 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal PTEN_C2 PF10409.9 ELR15027.1 - 6.8e-14 51.8 0.0 1.1e-13 51.1 0.0 1.2 1 0 0 1 1 1 1 C2 domain of PTEN tumour-suppressor protein Y_phosphatase PF00102.27 ELR15027.1 - 1e-06 28.5 0.0 1.9e-06 27.6 0.0 1.4 1 1 0 1 1 1 1 Protein-tyrosine phosphatase DSPc PF00782.20 ELR15027.1 - 3.9e-05 23.5 0.0 6.9e-05 22.7 0.0 1.4 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain LUC7 PF03194.15 ELR15028.1 - 1.2e-74 251.2 1.5 1.9e-74 250.5 1.5 1.3 1 0 0 1 1 1 1 LUC7 N_terminus FlxA PF14282.6 ELR15028.1 - 0.14 12.1 6.7 0.34 10.9 5.5 2.3 1 1 1 2 2 2 0 FlxA-like protein DUF3684 PF12449.8 ELR15029.1 - 0.098 10.4 0.0 0.12 10.1 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3684) SOG2 PF10428.9 ELR15029.1 - 5.7 6.0 7.2 0.16 11.1 1.0 1.5 2 0 0 2 2 2 0 RAM signalling pathway protein Sfi1_C PF10638.9 ELR15030.1 - 0.024 15.4 0.4 0.037 14.8 0.1 1.6 1 1 1 2 2 2 0 Spindle body associated protein C-terminus DZR PF12773.7 ELR15031.1 - 6.6e-05 22.9 0.3 0.00015 21.7 0.3 1.6 1 0 0 1 1 1 1 Double zinc ribbon zinc_ribbon_2 PF13240.6 ELR15031.1 - 0.0003 20.4 1.9 0.00073 19.2 1.9 1.7 1 0 0 1 1 1 1 zinc-ribbon domain zf-ribbon_3 PF13248.6 ELR15031.1 - 0.0024 17.2 0.7 0.0024 17.2 0.7 1.8 2 0 0 2 2 2 1 zinc-ribbon domain zinc_ribbon_15 PF17032.5 ELR15031.1 - 0.053 14.3 0.0 0.1 13.3 0.0 1.5 1 0 0 1 1 1 0 zinc-ribbon family GFA PF04828.14 ELR15031.1 - 0.12 12.7 0.3 5.7 7.3 0.3 2.4 1 1 0 1 1 1 0 Glutathione-dependent formaldehyde-activating enzyme Casc1_N PF15927.5 ELR15031.1 - 9.1 5.9 14.3 17 5.0 14.3 1.4 1 0 0 1 1 1 0 Cancer susceptibility candidate 1 N-terminus DZR PF12773.7 ELR15032.1 - 1.5e-05 24.9 0.3 2.5e-05 24.2 0.3 1.4 1 0 0 1 1 1 1 Double zinc ribbon zinc_ribbon_2 PF13240.6 ELR15032.1 - 5e-05 22.9 9.7 0.00041 20.0 3.4 1.7 1 1 1 2 2 2 2 zinc-ribbon domain zf-ribbon_3 PF13248.6 ELR15032.1 - 0.00048 19.4 1.9 0.001 18.4 1.9 1.6 1 1 0 1 1 1 1 zinc-ribbon domain ProSAAS PF07259.12 ELR15032.1 - 0.0032 17.5 0.8 0.0032 17.5 0.8 1.1 1 0 0 1 1 1 1 ProSAAS precursor GFA PF04828.14 ELR15032.1 - 0.0054 17.1 0.4 0.9 9.9 0.0 2.2 1 1 1 2 2 2 2 Glutathione-dependent formaldehyde-activating enzyme zinc_ribbon_15 PF17032.5 ELR15032.1 - 0.0098 16.6 0.1 0.01 16.5 0.1 1.1 1 0 0 1 1 1 1 zinc-ribbon family Nudix_N_2 PF14803.6 ELR15032.1 - 0.1 12.5 2.5 5.8 6.9 0.3 2.8 2 0 0 2 2 2 0 Nudix N-terminal Ribosomal_L37e PF01907.19 ELR15032.1 - 0.14 12.3 0.9 0.21 11.8 0.9 1.2 1 0 0 1 1 1 0 Ribosomal protein L37e DUF2116 PF09889.9 ELR15032.1 - 0.2 11.7 0.8 0.36 10.9 0.8 1.4 1 0 0 1 1 1 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) zf-C3HC4_2 PF13923.6 ELR15032.1 - 0.35 10.7 4.4 37 4.3 0.2 2.1 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) IBR PF01485.21 ELR15032.1 - 1.6 9.1 5.2 4.8 7.5 3.6 2.0 1 1 1 2 2 2 0 IBR domain, a half RING-finger domain zf-NADH-PPase PF09297.11 ELR15032.1 - 3.1 7.5 7.4 2.1 8.1 1.0 2.3 1 1 1 2 2 2 0 NADH pyrophosphatase zinc ribbon domain DUF1685 PF07939.11 ELR15033.1 - 0.015 15.0 0.0 0.019 14.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1685) CH PF00307.31 ELR15035.1 - 4.1e-06 26.9 0.0 7.6e-06 26.1 0.0 1.5 1 0 0 1 1 1 1 Calponin homology (CH) domain DUF1731 PF08338.11 ELR15036.1 - 1.4e-18 66.5 0.1 2.6e-18 65.6 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1731) Epimerase PF01370.21 ELR15036.1 - 3.8e-09 36.4 0.5 5.7e-07 29.2 0.1 2.5 2 1 0 2 2 2 2 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 ELR15036.1 - 0.0011 18.4 0.2 0.019 14.4 0.1 2.3 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase NAD_binding_10 PF13460.6 ELR15036.1 - 0.0031 17.4 1.7 0.15 12.0 1.7 2.2 1 1 0 1 1 1 1 NAD(P)H-binding KR PF08659.10 ELR15036.1 - 0.13 12.2 1.2 0.22 11.4 1.2 1.5 1 1 0 1 1 1 0 KR domain ESCRT-II PF05871.12 ELR15037.1 - 1.9e-39 135.1 0.1 2.3e-39 134.8 0.1 1.1 1 0 0 1 1 1 1 ESCRT-II complex subunit ABC2_membrane PF01061.24 ELR15038.1 - 1.6e-38 132.2 19.0 1.6e-38 132.2 19.0 1.7 3 0 0 3 3 3 1 ABC-2 type transporter SPC22 PF04573.12 ELR15038.1 - 1.1e-24 86.8 0.5 2.3e-24 85.8 0.5 1.5 1 0 0 1 1 1 1 Signal peptidase subunit ABC2_membrane_3 PF12698.7 ELR15038.1 - 0.0015 17.7 17.9 0.0034 16.5 17.9 1.8 1 1 0 1 1 1 1 ABC-2 family transporter protein DUF2070 PF09843.9 ELR15038.1 - 2.8 6.1 7.5 15 3.7 7.6 2.0 2 0 0 2 2 2 0 Predicted membrane protein (DUF2070) SPC22 PF04573.12 ELR15040.1 - 1.9e-32 112.1 1.4 2.1e-32 112.0 1.4 1.0 1 0 0 1 1 1 1 Signal peptidase subunit PH PF00169.29 ELR15042.1 - 7e-14 52.2 0.0 5.8e-13 49.3 0.0 2.0 2 0 0 2 2 2 1 PH domain Myotub-related PF06602.14 ELR15042.1 - 1.8e-07 30.4 0.0 3.3e-07 29.6 0.0 1.3 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain PH_11 PF15413.6 ELR15042.1 - 0.00023 21.5 0.0 0.0005 20.5 0.0 1.5 1 0 0 1 1 1 1 Pleckstrin homology domain PH_3 PF14593.6 ELR15042.1 - 0.0098 16.0 0.1 0.051 13.7 0.1 2.3 1 1 0 1 1 1 1 PH domain PH_8 PF15409.6 ELR15042.1 - 0.023 15.0 0.1 0.051 13.9 0.1 1.6 1 1 0 1 1 1 0 Pleckstrin homology domain Myotub-related PF06602.14 ELR15043.1 - 5.3e-18 65.1 0.0 1.1e-17 64.1 0.0 1.4 1 1 0 1 1 1 1 Myotubularin-like phosphatase domain GRAM PF02893.20 ELR15043.1 - 0.064 13.1 0.0 0.12 12.3 0.0 1.3 1 0 0 1 1 1 0 GRAM domain Bax1-I PF01027.20 ELR15044.1 - 0.063 13.1 0.1 0.084 12.7 0.1 1.1 1 0 0 1 1 1 0 Inhibitor of apoptosis-promoting Bax1 Glyco_hydro_46 PF01374.18 ELR15044.1 - 0.44 10.1 2.6 1.6 8.3 0.3 2.4 1 1 1 2 2 2 0 Glycosyl hydrolase family 46 MRP-S28 PF10213.9 ELR15045.1 - 5e-13 49.6 1.3 1.5e-12 48.0 0.0 2.3 2 0 0 2 2 2 1 Mitochondrial ribosomal subunit protein FAO_M PF16350.5 ELR15045.1 - 0.081 13.3 0.0 0.22 11.9 0.0 1.7 1 0 0 1 1 1 0 FAD dependent oxidoreductase central domain TMEM214 PF10151.9 ELR15045.1 - 3.2 6.1 5.3 4.7 5.5 5.3 1.2 1 0 0 1 1 1 0 TMEM214, C-terminal, caspase 4 activator Pribosyltran PF00156.27 ELR15046.1 - 1.9e-27 95.7 0.2 2.6e-27 95.3 0.2 1.2 1 0 0 1 1 1 1 Phosphoribosyl transferase domain THF_DHG_CYH_C PF02882.19 ELR15046.1 - 0.019 14.3 0.9 1 8.7 0.1 2.1 1 1 1 2 2 2 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Myotub-related PF06602.14 ELR15047.1 - 6.7e-14 51.6 0.1 9.6e-14 51.1 0.1 1.1 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain Sharpin_PH PF16764.5 ELR15047.1 - 0.11 12.2 0.4 6.3 6.6 0.4 2.6 2 0 0 2 2 2 0 Sharpin PH domain LRR_8 PF13855.6 ELR15048.1 - 4.2e-16 58.5 23.0 1.3e-06 28.0 1.2 4.2 2 2 2 4 4 4 4 Leucine rich repeat LRR_4 PF12799.7 ELR15048.1 - 4.5e-16 58.7 20.6 8.5e-09 35.6 3.9 4.3 3 1 1 4 4 4 4 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 ELR15048.1 - 3.9e-05 23.6 22.7 0.19 12.4 0.3 5.7 5 1 0 5 5 5 4 Leucine Rich Repeat LRR_6 PF13516.6 ELR15048.1 - 7.1e-05 22.5 22.0 0.062 13.4 0.6 5.4 6 0 0 6 6 6 3 Leucine Rich repeat LRR_5 PF13306.6 ELR15048.1 - 0.014 15.3 0.1 1.2 9.1 0.0 2.2 2 0 0 2 2 2 0 BspA type Leucine rich repeat region (6 copies) Pkinase_Tyr PF07714.17 ELR15049.1 - 8.1e-51 172.8 0.0 1.3e-50 172.1 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase COR PF16095.5 ELR15049.1 - 1.8e-45 155.1 0.0 2.9e-45 154.5 0.0 1.3 1 0 0 1 1 1 1 C-terminal of Roc, COR, domain Myotub-related PF06602.14 ELR15049.1 - 3.1e-44 151.4 2.1 4.8e-44 150.7 2.1 1.2 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain Pkinase PF00069.25 ELR15049.1 - 1.6e-41 142.4 0.0 2.7e-41 141.7 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain LRR_8 PF13855.6 ELR15049.1 - 1.6e-38 130.2 29.4 4.4e-11 42.4 1.5 6.7 5 2 2 7 7 7 7 Leucine rich repeat LRR_4 PF12799.7 ELR15049.1 - 3.6e-25 87.6 31.2 9.2e-05 22.7 1.1 8.4 5 2 5 10 10 10 7 Leucine Rich repeats (2 copies) WD40 PF00400.32 ELR15049.1 - 9.1e-22 77.0 2.0 8e-05 23.3 0.0 7.0 5 1 1 6 6 6 4 WD domain, G-beta repeat Roc PF08477.13 ELR15049.1 - 7.5e-21 74.6 0.1 1.1e-19 70.9 0.1 2.5 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 ELR15049.1 - 1.8e-09 37.4 0.0 4.5e-09 36.1 0.0 1.7 1 1 0 1 1 1 1 Ras family LRR_1 PF00560.33 ELR15049.1 - 4.2e-08 32.7 22.5 0.38 11.5 0.1 9.8 9 1 0 9 9 8 3 Leucine Rich Repeat LRR_9 PF14580.6 ELR15049.1 - 5.3e-05 22.8 8.7 0.015 14.8 0.2 3.5 2 1 1 3 3 3 2 Leucine-rich repeat F-box-like PF12937.7 ELR15049.1 - 0.00021 21.1 1.2 0.00087 19.1 1.2 2.1 1 0 0 1 1 1 1 F-box-like MMR_HSR1 PF01926.23 ELR15049.1 - 0.0011 19.0 0.0 0.0029 17.7 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase ANAPC4_WD40 PF12894.7 ELR15049.1 - 0.0012 19.0 1.5 0.41 11.0 0.4 3.5 1 1 1 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain F-box PF00646.33 ELR15049.1 - 0.14 12.1 0.1 0.35 10.8 0.1 1.7 1 0 0 1 1 1 0 F-box domain SRP-alpha_N PF04086.13 ELR15049.1 - 9 6.1 17.6 25 4.7 17.6 1.7 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal F-box-like PF12937.7 ELR15051.1 - 2.1e-05 24.3 0.0 3.1e-05 23.8 0.0 1.3 1 0 0 1 1 1 1 F-box-like DUF3778 PF12620.8 ELR15051.1 - 0.11 12.1 0.0 0.21 11.2 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3778) Aminotran_1_2 PF00155.21 ELR15052.1 - 1.7e-53 182.1 0.0 2e-53 181.8 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II DegT_DnrJ_EryC1 PF01041.17 ELR15052.1 - 2.5e-08 33.7 0.3 4.5e-08 32.8 0.0 1.5 2 0 0 2 2 2 1 DegT/DnrJ/EryC1/StrS aminotransferase family Cys_Met_Meta_PP PF01053.20 ELR15052.1 - 0.00013 20.7 0.0 0.0002 20.0 0.0 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_5 PF00266.19 ELR15052.1 - 0.00088 18.3 0.0 0.0012 17.9 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class-V Alliinase_C PF04864.13 ELR15052.1 - 0.025 13.4 0.0 0.04 12.8 0.0 1.2 1 0 0 1 1 1 0 Allinase Beta_elim_lyase PF01212.21 ELR15052.1 - 0.2 10.9 0.0 0.31 10.3 0.0 1.3 1 0 0 1 1 1 0 Beta-eliminating lyase DPBB_1 PF03330.18 ELR15053.1 - 2.5e-10 40.5 0.1 5.3e-10 39.4 0.1 1.5 1 1 0 1 1 1 1 Lytic transglycolase Barwin PF00967.17 ELR15053.1 - 0.051 13.4 0.1 0.064 13.1 0.1 1.2 1 0 0 1 1 1 0 Barwin family DUF4448 PF14610.6 ELR15054.1 - 0.07 12.9 0.2 0.12 12.1 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4448) Meth_synt_2 PF01717.18 ELR15055.1 - 2.5e-121 404.9 0.0 1.5e-120 402.4 0.0 2.1 2 0 0 2 2 2 1 Cobalamin-independent synthase, Catalytic domain Meth_synt_1 PF08267.12 ELR15055.1 - 3.3e-86 289.6 0.0 2e-77 260.8 0.0 2.4 2 0 0 2 2 2 2 Cobalamin-independent synthase, N-terminal domain Endonuc-BglII PF09195.11 ELR15055.1 - 0.081 12.8 0.0 0.2 11.5 0.0 1.6 1 0 0 1 1 1 0 Restriction endonuclease BglII VbhA PF18495.1 ELR15055.1 - 0.11 12.4 1.0 1.5 8.7 0.0 3.1 3 0 0 3 3 3 0 Antitoxin VbhA LIM PF00412.22 ELR15056.1 - 4.4e-09 36.4 9.8 7.2e-09 35.7 9.8 1.4 1 0 0 1 1 1 1 LIM domain APG6_N PF17675.1 ELR15056.1 - 0.002 18.6 11.5 0.002 18.6 11.5 3.0 1 1 1 2 2 2 1 Apg6 coiled-coil region SWIRM-assoc_1 PF16495.5 ELR15056.1 - 0.026 14.5 3.9 0.026 14.5 3.9 3.8 2 1 3 5 5 5 0 SWIRM-associated region 1 Spc7 PF08317.11 ELR15056.1 - 0.17 10.8 24.8 0.19 10.6 24.1 1.5 1 1 0 1 1 1 0 Spc7 kinetochore protein Mod_r PF07200.13 ELR15056.1 - 1.8 8.6 15.6 3.2 7.8 11.7 2.3 1 1 1 2 2 2 0 Modifier of rudimentary (Mod(r)) protein Exonuc_VII_L PF02601.15 ELR15056.1 - 2.4 7.7 16.6 4.3 6.8 16.6 1.4 1 1 0 1 1 1 0 Exonuclease VII, large subunit ERM PF00769.19 ELR15056.1 - 2.5 7.9 34.6 5.3 6.8 34.6 1.5 1 1 0 1 1 1 0 Ezrin/radixin/moesin family zinc_ribbon_9 PF14369.6 ELR15056.1 - 5.3 7.4 6.7 13 6.2 6.7 1.6 1 0 0 1 1 1 0 zinc-ribbon XkdW PF09636.10 ELR15056.1 - 9.2 6.4 11.6 0.25 11.4 3.3 2.4 1 1 2 3 3 3 0 XkdW protein RhoGAP PF00620.27 ELR15058.1 - 5.6e-30 104.2 0.3 3.3e-29 101.7 0.0 2.1 2 0 0 2 2 2 1 RhoGAP domain Exo_endo_phos PF03372.23 ELR15058.1 - 3.3e-08 33.3 0.1 6.5e-08 32.4 0.1 1.5 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Motile_Sperm PF00635.26 ELR15058.1 - 0.036 13.9 0.1 0.11 12.4 0.1 1.8 1 0 0 1 1 1 0 MSP (Major sperm protein) domain Myotub-related PF06602.14 ELR15059.1 - 3.8e-68 230.0 0.4 5.7e-68 229.4 0.4 1.3 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain Pkinase_Tyr PF07714.17 ELR15059.1 - 9.9e-48 162.7 0.0 7.1e-47 159.9 0.0 2.2 1 1 0 1 1 1 1 Protein tyrosine kinase COR PF16095.5 ELR15059.1 - 2.2e-42 145.1 0.0 4.3e-42 144.1 0.0 1.5 1 0 0 1 1 1 1 C-terminal of Roc, COR, domain Pkinase PF00069.25 ELR15059.1 - 3.3e-39 134.8 0.0 1.1e-38 133.1 0.0 1.8 2 1 0 2 2 2 1 Protein kinase domain LRR_8 PF13855.6 ELR15059.1 - 1.2e-37 127.4 19.1 1.1e-10 41.1 0.2 6.2 4 2 2 6 6 6 6 Leucine rich repeat LRR_4 PF12799.7 ELR15059.1 - 1.2e-29 101.8 18.1 3.9e-06 27.1 0.0 8.2 6 2 1 8 8 8 7 Leucine Rich repeats (2 copies) Roc PF08477.13 ELR15059.1 - 2e-21 76.5 0.0 6.3e-19 68.4 0.0 3.2 2 1 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase LRR_1 PF00560.33 ELR15059.1 - 2.4e-11 42.5 19.3 1.2 9.9 0.1 11.4 12 1 0 12 12 10 3 Leucine Rich Repeat PH PF00169.29 ELR15059.1 - 5.3e-10 39.7 0.0 1.4e-09 38.4 0.0 1.7 1 0 0 1 1 1 1 PH domain Ras PF00071.22 ELR15059.1 - 1.5e-07 31.2 0.0 4.3e-06 26.4 0.0 2.4 1 1 0 1 1 1 1 Ras family LRR_6 PF13516.6 ELR15059.1 - 4.3e-07 29.5 21.8 1.7 8.9 0.1 9.8 10 0 0 10 10 10 2 Leucine Rich repeat LRR_9 PF14580.6 ELR15059.1 - 0.00059 19.4 5.2 0.091 12.3 0.0 4.4 3 1 2 5 5 5 1 Leucine-rich repeat PH_9 PF15410.6 ELR15059.1 - 0.00061 20.1 0.0 0.0017 18.7 0.0 1.8 1 0 0 1 1 1 1 Pleckstrin homology domain PH_3 PF14593.6 ELR15059.1 - 0.0034 17.4 0.0 0.028 14.5 0.0 2.5 2 1 0 2 2 2 1 PH domain PH_8 PF15409.6 ELR15059.1 - 0.0087 16.3 0.0 0.032 14.5 0.0 2.0 1 0 0 1 1 1 1 Pleckstrin homology domain MMR_HSR1 PF01926.23 ELR15059.1 - 0.014 15.5 0.0 0.046 13.8 0.0 2.0 1 0 0 1 1 1 0 50S ribosome-binding GTPase PH_2 PF08458.10 ELR15059.1 - 0.027 14.8 0.1 0.17 12.3 0.0 2.2 2 0 0 2 2 2 0 Plant pleckstrin homology-like region PH_11 PF15413.6 ELR15059.1 - 0.037 14.4 0.0 0.21 12.0 0.0 2.3 1 1 0 1 1 1 0 Pleckstrin homology domain AAA_16 PF13191.6 ELR15059.1 - 4.5 7.6 6.2 10 6.5 0.0 4.0 5 1 0 5 5 4 0 AAA ATPase domain Rhomboid PF01694.22 ELR15060.1 - 3.5e-34 118.0 14.1 6.7e-34 117.1 14.1 1.5 1 0 0 1 1 1 1 Rhomboid family DPBB_1 PF03330.18 ELR15062.1 - 4.4e-13 49.3 0.0 5.5e-13 49.0 0.0 1.1 1 0 0 1 1 1 1 Lytic transglycolase DUF2367 PF10164.9 ELR15062.1 - 0.082 13.4 0.0 0.11 13.0 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2367) Ribosomal_S27 PF01599.19 ELR15062.1 - 0.19 11.9 1.2 19 5.5 0.1 2.3 2 0 0 2 2 2 0 Ribosomal protein S27a DIM PF08194.12 ELR15062.1 - 0.78 10.0 4.2 2.6 8.3 4.2 1.9 1 0 0 1 1 1 0 DIM protein PBP1_TM PF14812.6 ELR15063.1 - 0.041 14.3 1.1 0.041 14.3 1.1 1.7 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal GMAP PF06540.11 ELR15064.1 - 0.21 11.6 0.0 0.38 10.9 0.0 1.4 1 0 0 1 1 1 0 Galanin message associated peptide (GMAP) LRR_6 PF13516.6 ELR15065.1 - 1.8e-16 58.7 33.8 0.044 13.9 0.1 11.3 13 0 0 13 13 13 5 Leucine Rich repeat SpoU_sub_bind PF08032.12 ELR15065.1 - 0.00035 20.8 0.7 25 5.2 0.0 5.7 4 1 1 5 5 5 1 RNA 2'-O ribose methyltransferase substrate binding LRR_4 PF12799.7 ELR15065.1 - 0.00056 20.3 7.8 0.13 12.8 0.0 5.8 5 1 1 6 6 6 1 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 ELR15065.1 - 0.006 17.0 0.0 1.4e+02 3.6 0.0 5.4 5 0 0 5 5 5 0 Leucine Rich Repeat ATG27 PF09451.10 ELR15067.1 - 1.2e-05 25.3 0.1 1.6e-05 24.9 0.1 1.1 1 0 0 1 1 1 1 Autophagy-related protein 27 SNF2_N PF00176.23 ELR15068.1 - 1e-70 238.3 0.0 3.1e-70 236.6 0.0 1.8 1 1 0 1 1 1 1 SNF2 family N-terminal domain zf-RING_2 PF13639.6 ELR15068.1 - 1.5e-06 28.4 10.9 1.5e-06 28.4 10.9 2.4 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4 PF00097.25 ELR15068.1 - 4.1e-06 26.6 11.4 4.1e-06 26.6 11.4 2.3 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) Helicase_C PF00271.31 ELR15068.1 - 3.1e-05 24.3 0.0 8.1e-05 22.9 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain zf-C3HC4_2 PF13923.6 ELR15068.1 - 9.3e-05 22.2 11.8 9.3e-05 22.2 11.8 2.0 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 ELR15068.1 - 9.7e-05 22.1 10.2 9.7e-05 22.1 10.2 2.6 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 ELR15068.1 - 0.00013 21.9 7.3 0.00037 20.5 7.3 1.8 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 ELR15068.1 - 0.00077 19.4 9.7 0.00077 19.4 9.7 2.7 3 0 0 3 3 3 1 zinc-RING finger domain Prok-RING_4 PF14447.6 ELR15068.1 - 0.059 13.2 8.5 0.18 11.7 8.5 1.8 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-RING_11 PF17123.5 ELR15068.1 - 0.09 12.5 8.7 0.22 11.3 8.7 1.7 1 0 0 1 1 1 0 RING-like zinc finger TPR_7 PF13176.6 ELR15068.1 - 0.61 10.2 3.2 9.8 6.5 0.9 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat HAD_2 PF13419.6 ELR15069.1 - 2.7e-07 30.8 1.7 1.2e-06 28.8 1.5 1.9 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 ELR15069.1 - 0.015 15.6 0.1 0.089 13.1 0.1 2.0 1 1 0 1 1 1 0 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 ELR15069.1 - 0.041 14.0 0.0 0.08 13.0 0.0 1.4 1 0 0 1 1 1 0 HAD-hyrolase-like GATA PF00320.27 ELR15071.1 - 3.6e-09 36.1 7.2 8.6e-09 34.9 7.2 1.7 1 0 0 1 1 1 1 GATA zinc finger Pyrophosphatase PF00719.19 ELR15072.1 - 3e-49 166.9 0.7 3.6e-49 166.7 0.7 1.1 1 0 0 1 1 1 1 Inorganic pyrophosphatase LPD15 PF18828.1 ELR15072.1 - 0.099 12.5 0.0 0.21 11.5 0.0 1.5 1 0 0 1 1 1 0 Large polyvalent-protein-associated domain 15 Bac_rhamnosid_C PF17390.2 ELR15072.1 - 0.12 12.2 0.0 0.26 11.1 0.0 1.5 1 0 0 1 1 1 0 Bacterial alpha-L-rhamnosidase C-terminal domain SH3_1 PF00018.28 ELR15073.1 - 2.6e-06 26.9 0.6 6.3e-06 25.7 0.6 1.7 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 ELR15073.1 - 7.4e-06 25.5 0.1 2e-05 24.2 0.1 1.8 1 1 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.6 ELR15073.1 - 0.0006 19.6 0.8 0.0082 16.0 0.3 2.6 2 0 0 2 2 2 1 Variant SH3 domain DUF4005 PF13178.6 ELR15073.1 - 3.9 8.2 11.0 5.2 7.8 6.7 3.1 2 0 0 2 2 2 0 Protein of unknown function (DUF4005) ZZ PF00569.17 ELR15074.1 - 0.047 13.5 3.0 0.12 12.2 3.0 1.7 1 0 0 1 1 1 0 Zinc finger, ZZ type LCAT PF02450.15 ELR15075.1 - 3.7e-56 191.0 0.0 2.7e-46 158.5 0.0 2.3 2 0 0 2 2 2 2 Lecithin:cholesterol acyltransferase C2 PF00168.30 ELR15075.1 - 1.7e-47 159.9 0.1 1.3e-22 80.1 0.1 2.3 2 0 0 2 2 2 2 C2 domain DUF676 PF05057.14 ELR15075.1 - 0.00017 21.2 0.0 0.00048 19.7 0.0 1.7 2 0 0 2 2 2 1 Putative serine esterase (DUF676) CEP76-C2 PF15627.6 ELR15075.1 - 0.0068 16.0 0.0 0.03 13.9 0.0 1.9 2 0 0 2 2 2 1 CEP76 C2 domain Abhydrolase_6 PF12697.7 ELR15075.1 - 0.028 15.0 0.1 0.075 13.6 0.1 1.8 1 0 0 1 1 1 0 Alpha/beta hydrolase family DUF726 PF05277.12 ELR15075.1 - 0.1 11.5 0.0 0.17 10.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF726) RasGEF PF00617.19 ELR15076.1 - 1.7e-46 158.6 0.0 3e-46 157.9 0.0 1.3 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 ELR15076.1 - 1.9e-12 47.3 0.0 8.6e-12 45.2 0.0 2.1 2 0 0 2 2 2 1 RasGEF N-terminal motif Tim54 PF11711.8 ELR15076.1 - 0.059 12.2 0.5 0.097 11.4 0.5 1.2 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 DUF1722 PF08349.11 ELR15076.1 - 0.07 13.4 0.0 0.25 11.6 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1722) DUF2201_N PF13203.6 ELR15076.1 - 0.076 12.6 3.1 0.13 11.8 3.1 1.4 1 0 0 1 1 1 0 Putative metallopeptidase domain eIF-3c_N PF05470.12 ELR15076.1 - 0.88 7.8 6.7 4.5 5.5 7.9 1.3 1 1 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 8 N-terminus TRAP_alpha PF03896.16 ELR15076.1 - 1 8.5 4.1 1.9 7.6 4.1 1.3 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Nop14 PF04147.12 ELR15076.1 - 1.2 7.3 9.8 0.35 9.0 6.8 1.5 2 0 0 2 2 2 0 Nop14-like family DUF4746 PF15928.5 ELR15076.1 - 2.3 7.6 13.2 1.8 7.9 8.8 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF4746) Sporozoite_P67 PF05642.11 ELR15076.1 - 3.3 5.7 5.4 4.7 5.2 5.4 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen RNA_pol_3_Rpc31 PF11705.8 ELR15076.1 - 4.6 7.4 14.3 1.5 9.0 9.4 2.2 2 0 0 2 2 2 0 DNA-directed RNA polymerase III subunit Rpc31 NOA36 PF06524.12 ELR15076.1 - 5 6.4 15.3 0.29 10.4 6.8 2.6 3 0 0 3 3 3 0 NOA36 protein CLU PF13236.6 ELR15077.1 - 9.1e-58 195.7 0.0 1.7e-57 194.8 0.0 1.5 1 0 0 1 1 1 1 Clustered mitochondria eIF3_p135 PF12807.7 ELR15077.1 - 1.8e-06 28.1 0.9 1.8e-06 28.1 0.9 3.8 5 0 0 5 5 5 1 Translation initiation factor eIF3 subunit 135 LRR_6 PF13516.6 ELR15077.1 - 0.0018 18.1 10.1 13 6.1 0.0 6.2 6 0 0 6 6 6 1 Leucine Rich repeat DUF3254 PF11630.8 ELR15077.1 - 0.015 15.5 0.0 0.057 13.6 0.0 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3254) LRR_4 PF12799.7 ELR15077.1 - 0.021 15.3 0.6 29 5.3 0.0 4.4 3 2 2 5 5 5 0 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 ELR15077.1 - 0.022 14.5 0.7 3.4 7.5 0.1 3.3 3 0 0 3 3 3 0 Leucine rich repeat GyrB_insert PF18053.1 ELR15077.1 - 0.057 13.3 0.6 0.44 10.4 0.0 2.7 2 0 0 2 2 2 0 DNA gyrase B subunit insert domain CLU PF13236.6 ELR15078.1 - 8.6e-13 48.6 0.0 9.1e-13 48.5 0.0 1.1 1 0 0 1 1 1 1 Clustered mitochondria LRR_6 PF13516.6 ELR15078.1 - 0.05 13.7 0.8 4.2 7.7 0.1 2.8 2 1 1 3 3 3 0 Leucine Rich repeat PIP5K PF01504.18 ELR15079.1 - 2.5e-75 253.3 0.2 1.8e-73 247.1 0.2 2.5 1 1 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase Dicty_CAR PF05462.11 ELR15079.1 - 1.4e-10 40.8 16.0 2.2e-10 40.2 16.0 1.2 1 0 0 1 1 1 1 Slime mold cyclic AMP receptor 7tm_2 PF00002.24 ELR15079.1 - 0.0088 15.4 12.9 0.015 14.6 12.9 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) 7tm_1 PF00001.21 ELR15079.1 - 0.0089 15.4 11.4 0.016 14.6 11.4 1.4 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) SpoVR PF04293.13 ELR15079.1 - 0.097 11.3 0.8 0.2 10.3 0.1 1.7 2 0 0 2 2 2 0 SpoVR like protein SR-25 PF10500.9 ELR15079.1 - 0.13 11.9 14.0 0.22 11.1 14.0 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein FolB PF02152.18 ELR15081.1 - 2e-26 92.7 0.9 2.4e-26 92.5 0.9 1.0 1 0 0 1 1 1 1 Dihydroneopterin aldolase TFIIF_alpha PF05793.12 ELR15083.1 - 0.15 10.6 59.3 0.22 10.1 59.3 1.2 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) CDC27 PF09507.10 ELR15083.1 - 1.3 8.3 53.4 2.6 7.3 53.4 1.5 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Pro_isomerase PF00160.21 ELR15085.1 - 6.5e-48 163.0 0.1 7.2e-48 162.8 0.1 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Glyco_hydro_18 PF00704.28 ELR15086.1 - 4.7e-28 98.8 0.0 6.1e-28 98.5 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 GHL15 PF14885.6 ELR15086.1 - 0.043 13.8 0.2 0.071 13.0 0.2 1.4 1 0 0 1 1 1 0 Hypothetical glycosyl hydrolase family 15 FHA PF00498.26 ELR15087.1 - 1.2e-18 67.2 0.0 2.1e-18 66.4 0.0 1.4 1 0 0 1 1 1 1 FHA domain Yop-YscD_cpl PF16697.5 ELR15087.1 - 1.6e-07 31.5 0.0 3.8e-07 30.3 0.0 1.6 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain SRP-alpha_N PF04086.13 ELR15087.1 - 0.048 13.6 29.5 0.065 13.2 29.5 1.3 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal CNDH2_C PF16858.5 ELR15087.1 - 0.16 11.8 22.7 0.25 11.2 22.7 1.3 1 0 0 1 1 1 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term Borrelia_P83 PF05262.11 ELR15087.1 - 0.46 8.9 26.5 0.53 8.7 26.5 1.2 1 0 0 1 1 1 0 Borrelia P83/100 protein DUF5427 PF10310.9 ELR15087.1 - 2 7.3 25.7 3.2 6.6 25.7 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5427) LCD1 PF09798.9 ELR15087.1 - 10 4.5 13.3 11 4.4 13.3 1.2 1 0 0 1 1 1 0 DNA damage checkpoint protein Pkinase PF00069.25 ELR15088.1 - 1.9e-65 220.9 0.1 8.1e-59 199.1 0.0 2.0 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ELR15088.1 - 4.6e-39 134.2 0.0 8.4e-39 133.4 0.0 1.4 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 ELR15088.1 - 0.086 11.6 0.0 0.096 11.4 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase Fis1_TPR_C PF14853.6 ELR15088.1 - 0.11 12.5 0.2 0.29 11.2 0.2 1.6 1 0 0 1 1 1 0 Fis1 C-terminal tetratricopeptide repeat IFRD PF05004.13 ELR15089.1 - 5.3e-06 25.8 2.4 0.0018 17.5 0.1 3.0 2 1 1 3 3 3 2 Interferon-related developmental regulator (IFRD) HEAT PF02985.22 ELR15089.1 - 0.0068 16.6 1.1 0.21 11.9 0.1 3.5 3 0 0 3 3 3 1 HEAT repeat Iwr1 PF08574.10 ELR15089.1 - 0.02 15.9 5.7 0.27 12.3 1.6 2.9 2 0 0 2 2 2 0 Transcription factor Iwr1 Pox_Ag35 PF03286.14 ELR15089.1 - 0.071 12.9 0.1 0.071 12.9 0.1 2.9 3 0 0 3 3 3 0 Pox virus Ag35 surface protein Acetyltransf_1 PF00583.25 ELR15090.1 - 6.4e-17 61.9 0.0 1e-16 61.2 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 ELR15090.1 - 6.9e-12 45.4 0.1 1.1e-11 44.8 0.1 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 ELR15090.1 - 2.4e-10 40.7 0.1 4.8e-10 39.7 0.1 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 ELR15090.1 - 1e-07 31.8 0.1 1.5e-07 31.3 0.1 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_6 PF13480.7 ELR15090.1 - 0.00012 22.3 0.8 0.00015 21.9 0.8 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 ELR15090.1 - 0.0025 17.9 0.1 0.0053 16.8 0.1 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_15 PF17013.5 ELR15090.1 - 0.0025 17.3 0.0 0.0027 17.2 0.0 1.2 1 0 0 1 1 1 1 Putative acetyl-transferase Acetyltransf_CG PF14542.6 ELR15090.1 - 0.004 17.2 0.1 0.007 16.5 0.1 1.4 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase Acetyltransf_3 PF13302.7 ELR15090.1 - 0.0044 17.7 0.1 0.0068 17.1 0.1 1.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Ras PF00071.22 ELR15091.1 - 1.9e-52 177.1 0.0 2.3e-52 176.9 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR15091.1 - 4.4e-16 59.2 0.0 6.2e-16 58.7 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase RsgA_GTPase PF03193.16 ELR15091.1 - 2.6e-06 27.4 0.0 0.00013 22.0 0.0 2.1 2 0 0 2 2 2 1 RsgA GTPase Arf PF00025.21 ELR15091.1 - 0.00023 20.6 0.0 0.00027 20.4 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 ELR15091.1 - 0.066 12.7 0.0 0.11 12.0 0.0 1.4 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain G-alpha PF00503.20 ELR15091.1 - 0.11 11.6 0.0 0.14 11.3 0.0 1.1 1 0 0 1 1 1 0 G-protein alpha subunit DSPc PF00782.20 ELR15092.1 - 1.4e-26 92.9 0.0 1.7e-26 92.6 0.0 1.1 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Init_tRNA_PT PF04179.12 ELR15092.1 - 0.002 18.4 0.0 0.0032 17.8 0.0 1.3 1 0 0 1 1 1 1 Rit1 DUSP-like domain Y_phosphatase PF00102.27 ELR15092.1 - 0.0022 17.6 0.0 0.0029 17.2 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Myc-LZ PF02344.15 ELR15092.1 - 0.035 14.2 0.5 0.067 13.3 0.5 1.4 1 0 0 1 1 1 0 Myc leucine zipper domain PTPlike_phytase PF14566.6 ELR15092.1 - 0.076 13.1 0.0 0.11 12.7 0.0 1.2 1 0 0 1 1 1 0 Inositol hexakisphosphate GRAM PF02893.20 ELR15093.1 - 2.1e-23 82.4 0.2 2.5e-10 40.2 0.0 2.9 2 0 0 2 2 2 2 GRAM domain DUF810 PF05664.11 ELR15093.1 - 4e-08 32.3 0.6 4e-08 32.3 0.6 2.9 3 0 0 3 3 3 2 Plant family of unknown function (DUF810) C2 PF00168.30 ELR15093.1 - 5.9e-08 32.9 0.1 2e-07 31.2 0.1 2.0 1 1 0 1 1 1 1 C2 domain Membr_traf_MHD PF10540.9 ELR15093.1 - 4.5e-07 30.1 0.5 0.025 14.7 0.0 3.8 2 1 1 3 3 3 2 Munc13 (mammalian uncoordinated) homology domain DUF996 PF06195.13 ELR15094.1 - 0.00033 21.0 0.2 0.0005 20.4 0.2 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF996) DUF3169 PF11368.8 ELR15094.1 - 0.0014 18.2 0.7 0.0021 17.6 0.7 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3169) DUF4112 PF13430.6 ELR15094.1 - 0.11 12.7 0.4 0.24 11.7 0.4 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4112) DUF874 PF05917.11 ELR15094.1 - 0.23 10.5 0.0 0.31 10.0 0.0 1.1 1 0 0 1 1 1 0 Helicobacter pylori protein of unknown function (DUF874) DUF948 PF06103.11 ELR15094.1 - 0.29 11.4 0.7 0.64 10.3 0.7 1.6 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF948) FixH PF05751.11 ELR15094.1 - 1.1 9.3 7.3 2.1 8.3 2.3 2.3 2 0 0 2 2 2 0 FixH Phage_holin_3_6 PF07332.11 ELR15094.1 - 1.3 9.1 7.1 2 8.5 7.1 1.2 1 0 0 1 1 1 0 Putative Actinobacterial Holin-X, holin superfamily III DUF1358 PF07096.11 ELR15094.1 - 5.2 7.1 6.4 18 5.4 0.2 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1358) RCC1 PF00415.18 ELR15095.1 - 9.3e-54 179.9 12.1 2.6e-13 50.4 0.0 7.5 6 1 1 7 7 7 7 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 ELR15095.1 - 2.8e-21 74.8 20.7 0.00018 21.2 0.3 6.4 6 0 0 6 6 6 5 Regulator of chromosome condensation (RCC1) repeat Chromo PF00385.24 ELR15095.1 - 1.6e-19 69.6 0.6 1.2e-14 53.9 0.2 3.1 2 0 0 2 2 2 2 Chromo (CHRromatin Organisation MOdifier) domain Ank_2 PF12796.7 ELR15095.1 - 4.1e-16 59.3 10.0 4.2e-13 49.7 1.2 2.2 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 ELR15095.1 - 8.9e-11 41.8 5.7 3.1e-05 24.2 0.4 2.9 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 ELR15095.1 - 1.4e-10 41.5 6.8 1.4e-05 25.5 0.1 3.3 4 0 0 4 4 4 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 ELR15095.1 - 7.2e-08 32.1 2.1 0.018 15.6 0.2 3.4 3 0 0 3 3 3 2 Ankyrin repeat Ank PF00023.30 ELR15095.1 - 0.00014 22.1 13.4 0.015 15.7 1.3 3.4 3 1 1 4 4 4 2 Ankyrin repeat DUF3446 PF11928.8 ELR15095.1 - 2.6 8.4 14.6 7.9 6.9 14.6 1.8 1 0 0 1 1 1 0 Early growth response N-terminal domain BTB_2 PF02214.22 ELR15096.1 - 1.9e-07 31.4 0.1 2.6e-07 30.9 0.1 1.2 1 0 0 1 1 1 1 BTB/POZ domain Bromodomain PF00439.25 ELR15097.1 - 2.2e-15 56.5 0.2 3.7e-15 55.7 0.2 1.3 1 0 0 1 1 1 1 Bromodomain Bromo_TP PF07524.13 ELR15097.1 - 0.00066 19.6 0.0 0.0015 18.5 0.0 1.5 1 0 0 1 1 1 1 Bromodomain associated K_channel_TID PF07941.11 ELR15097.1 - 0.02 15.4 3.0 0.02 15.4 3.0 6.6 5 2 2 7 7 7 0 Potassium channel Kv1.4 tandem inactivation domain BSP_II PF05432.11 ELR15097.1 - 1.1 8.9 15.9 0.18 11.5 2.6 2.3 2 0 0 2 2 2 0 Bone sialoprotein II (BSP-II) RRM_1 PF00076.22 ELR15099.1 - 0.026 14.3 0.0 0.059 13.2 0.0 1.6 1 1 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) GST_C_3 PF14497.6 ELR15100.1 - 3e-21 75.5 0.0 4.5e-21 74.9 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 ELR15100.1 - 4.2e-12 46.2 0.0 7.8e-12 45.4 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 ELR15100.1 - 2.6e-09 37.2 0.1 5.9e-09 36.0 0.1 1.7 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 ELR15100.1 - 7.7e-06 25.8 0.0 2.1e-05 24.5 0.0 1.8 2 1 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 ELR15100.1 - 7.7e-05 23.0 0.0 0.00018 21.9 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain Rrp15p PF07890.12 ELR15100.1 - 0.0029 17.9 0.1 0.0049 17.2 0.1 1.3 1 0 0 1 1 1 1 Rrp15p Exo_endo_phos PF03372.23 ELR15101.1 - 3.5e-17 62.7 0.6 1.2e-16 61.0 0.6 1.8 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family CBS PF00571.28 ELR15103.1 - 1e-30 105.9 3.3 5e-09 36.5 0.0 4.3 4 0 0 4 4 4 4 CBS domain Aldolase_II PF00596.21 ELR15103.1 - 0.071 13.0 0.0 0.1 12.5 0.0 1.2 1 0 0 1 1 1 0 Class II Aldolase and Adducin N-terminal domain MORN PF02493.20 ELR15104.1 - 2.6e-28 96.2 59.5 4.5e-06 26.2 1.8 7.9 8 0 0 8 8 8 6 MORN repeat F-box-like PF12937.7 ELR15104.1 - 5.1e-11 42.3 0.3 3.1e-10 39.8 0.1 2.1 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 ELR15104.1 - 0.0024 17.7 0.1 0.0046 16.8 0.1 1.5 1 0 0 1 1 1 1 F-box domain DUF4304 PF14137.6 ELR15104.1 - 0.12 12.5 0.7 0.44 10.7 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4304) DEC-1_N PF04625.13 ELR15104.1 - 0.82 8.6 3.4 1.2 8.0 3.4 1.2 1 0 0 1 1 1 0 DEC-1 protein, N-terminal region DSPc PF00782.20 ELR15105.1 - 7.8e-11 41.9 0.0 9.2e-11 41.7 0.0 1.1 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.6 ELR15105.1 - 4.6e-06 26.8 0.0 6.8e-06 26.3 0.0 1.2 1 0 0 1 1 1 1 Inositol hexakisphosphate Y_phosphatase PF00102.27 ELR15105.1 - 2e-05 24.3 0.0 2.4e-05 24.0 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase CDKN3 PF05706.12 ELR15105.1 - 0.00012 21.8 0.0 0.00016 21.4 0.0 1.2 1 0 0 1 1 1 1 Cyclin-dependent kinase inhibitor 3 (CDKN3) Y_phosphatase3 PF13350.6 ELR15105.1 - 0.068 13.1 0.0 0.095 12.6 0.0 1.2 1 0 0 1 1 1 0 Tyrosine phosphatase family DUF442 PF04273.13 ELR15105.1 - 0.18 11.9 0.0 0.26 11.4 0.0 1.2 1 0 0 1 1 1 0 Putative phosphatase (DUF442) CUE PF02845.16 ELR15106.1 - 0.00024 20.7 0.2 0.0094 15.6 0.0 3.2 3 0 0 3 3 3 1 CUE domain AP3D1 PF06375.11 ELR15106.1 - 0.014 15.7 9.4 0.014 15.7 9.4 4.2 3 1 1 4 4 4 0 AP-3 complex subunit delta-1 BRCT PF00533.26 ELR15106.1 - 0.22 12.0 1.0 9.2 6.7 0.0 3.0 3 0 0 3 3 3 0 BRCA1 C Terminus (BRCT) domain Sod_Cu PF00080.20 ELR15107.1 - 5.6e-75 250.2 21.8 2.6e-29 102.2 4.6 3.3 3 0 0 3 3 3 3 Copper/zinc superoxide dismutase (SODC) Ras PF00071.22 ELR15108.1 - 1.5e-35 122.2 0.0 1.9e-35 121.8 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR15108.1 - 3.4e-08 33.7 0.0 5.7e-08 33.0 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR15108.1 - 0.0038 16.7 0.0 0.0043 16.5 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 ELR15108.1 - 0.0049 16.4 0.0 0.0067 16.0 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain G-alpha PF00503.20 ELR15108.1 - 0.032 13.4 0.1 0.044 12.9 0.1 1.1 1 0 0 1 1 1 0 G-protein alpha subunit HDC PF02329.16 ELR15108.1 - 0.058 12.4 0.0 6.9 5.6 0.0 2.1 1 1 1 2 2 2 0 Histidine carboxylase PI chain FA_hydroxylase PF04116.13 ELR15109.1 - 2.7e-16 60.1 6.4 2.7e-16 60.1 6.4 2.9 3 0 0 3 3 3 1 Fatty acid hydroxylase superfamily DUF996 PF06195.13 ELR15109.1 - 0.036 14.4 0.1 0.083 13.2 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF996) SH3_9 PF14604.6 ELR15110.1 - 3.7e-29 100.3 2.7 2.1e-15 56.3 0.5 2.5 2 0 0 2 2 2 2 Variant SH3 domain SH3_1 PF00018.28 ELR15110.1 - 2e-27 94.5 2.1 4.3e-13 48.6 0.1 2.5 2 0 0 2 2 2 2 SH3 domain SH3_2 PF07653.17 ELR15110.1 - 1.8e-24 85.2 0.0 2.8e-12 46.1 0.0 2.4 2 0 0 2 2 2 2 Variant SH3 domain FCH PF00611.23 ELR15110.1 - 3.4e-14 52.9 0.1 2e-13 50.4 0.0 2.2 2 0 0 2 2 2 1 Fes/CIP4, and EFC/F-BAR homology domain HEPN_Toprim_N PF18871.1 ELR15110.1 - 0.23 11.4 2.8 0.94 9.4 2.8 1.8 1 1 1 2 2 2 0 HEPN/Toprim N-terminal domain 1 DUF4407 PF14362.6 ELR15110.1 - 0.79 9.0 9.7 1.1 8.5 9.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF632 PF04782.12 ELR15110.1 - 0.9 8.8 12.6 0.039 13.3 3.8 2.5 1 1 0 2 2 2 0 Protein of unknown function (DUF632) TMF_DNA_bd PF12329.8 ELR15110.1 - 5.7 7.0 16.3 4.6 7.3 3.6 2.5 1 1 1 2 2 2 0 TATA element modulatory factor 1 DNA binding Syntaxin-6_N PF09177.11 ELR15110.1 - 8.3 7.0 9.6 62 4.2 8.7 2.4 1 1 1 2 2 2 0 Syntaxin 6, N-terminal DUF702 PF05142.12 ELR15111.1 - 3.8e-06 27.4 4.8 8.5e-06 26.3 4.8 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF702) Ish1 PF10281.9 ELR15111.1 - 0.11 12.8 0.0 0.41 11.0 0.0 2.0 2 0 0 2 2 2 0 Putative stress-responsive nuclear envelope protein Mito_carr PF00153.27 ELR15112.1 - 9.2e-06 25.5 0.0 6.6e-05 22.8 0.0 2.4 3 0 0 3 3 3 1 Mitochondrial carrier protein SLT PF01464.20 ELR15113.1 - 6.3e-07 29.1 0.0 7.6e-07 28.8 0.0 1.2 1 0 0 1 1 1 1 Transglycosylase SLT domain Lys PF00062.20 ELR15113.1 - 4.7e-06 26.9 4.3 1.7e-05 25.1 4.3 1.8 1 1 0 1 1 1 1 C-type lysozyme/alpha-lactalbumin family Ndc1_Nup PF09531.10 ELR15114.1 - 5.6 5.5 12.9 1.5 7.4 9.3 1.9 2 0 0 2 2 2 0 Nucleoporin protein Ndc1-Nup EGF_2 PF07974.13 ELR15115.1 - 3.7e-30 104.0 182.0 0.00012 22.3 10.4 13.5 13 0 0 13 13 13 12 EGF-like domain EGF PF00008.27 ELR15115.1 - 3.9e-16 59.0 138.4 7e-05 23.0 3.4 12.5 12 0 0 12 12 12 10 EGF-like domain hEGF PF12661.7 ELR15115.1 - 5.2e-08 33.2 130.0 0.051 14.2 2.7 13.4 12 0 0 12 12 12 10 Human growth factor-like EGF Proteasom_Rpn13 PF04683.13 ELR15116.1 - 4.8e-29 100.7 0.3 7e-29 100.2 0.3 1.2 1 0 0 1 1 1 1 Proteasome complex subunit Rpn13 ubiquitin receptor RPN13_C PF16550.5 ELR15116.1 - 4.9e-29 100.8 1.0 1.1e-28 99.6 0.5 1.9 2 0 0 2 2 2 1 UCH-binding domain Med25_VWA PF11265.8 ELR15117.1 - 5.3e-29 101.6 0.0 8.2e-29 100.9 0.0 1.2 1 0 0 1 1 1 1 Mediator complex subunit 25 von Willebrand factor type A VWA_2 PF13519.6 ELR15117.1 - 0.063 13.9 0.0 0.13 12.9 0.0 1.6 1 0 0 1 1 1 0 von Willebrand factor type A domain LRR_4 PF12799.7 ELR15118.1 - 0.00028 21.2 12.9 0.43 11.1 0.1 6.2 4 2 2 6 6 6 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 ELR15118.1 - 0.12 12.2 12.0 1.3 8.9 0.7 4.9 4 2 1 5 5 5 0 Leucine rich repeat DUF3659 PF12396.8 ELR15119.1 - 0.0016 18.3 0.8 0.0079 16.1 0.7 2.2 1 1 0 1 1 1 1 Protein of unknown function (DUF3659) Baculo_PEP_C PF04513.12 ELR15119.1 - 0.0082 16.2 9.7 0.016 15.3 5.8 2.1 1 1 1 2 2 2 2 Baculovirus polyhedron envelope protein, PEP, C terminus TetR_C_20 PF17925.1 ELR15119.1 - 0.11 12.9 0.0 0.43 10.9 0.0 1.9 1 1 1 2 2 2 0 Tetracyclin repressor-like, C-terminal domain TFCD_C PF12612.8 ELR15119.1 - 0.37 10.6 2.4 0.76 9.6 2.3 1.4 1 1 0 1 1 1 0 Tubulin folding cofactor D C terminal BORCS6 PF10157.9 ELR15119.1 - 0.71 10.1 3.0 7 6.9 0.2 2.4 1 1 0 2 2 2 0 BLOC-1-related complex sub-unit 6 LAG1-DNAbind PF09271.11 ELR15120.1 - 0.036 14.7 6.2 0.95 10.1 0.1 2.5 2 0 0 2 2 2 0 LAG1, DNA binding Nop53 PF07767.11 ELR15120.1 - 0.31 10.4 13.7 0.44 9.9 13.7 1.2 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) MMR1 PF08505.10 ELR15120.1 - 1.6 8.9 12.3 2.5 8.3 12.3 1.3 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein Neur_chan_memb PF02932.16 ELR15120.1 - 1.9 8.5 6.0 2.7 8.0 6.0 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Med15 PF09606.10 ELR15120.1 - 2.2 6.9 31.7 2.9 6.5 31.7 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal DUF935 PF06074.12 ELR15120.1 - 6.5 5.4 18.3 1e+02 1.4 0.0 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF935) Spt5_N PF11942.8 ELR15120.1 - 6.9 7.7 16.9 0.24 12.4 7.9 2.5 2 1 1 3 3 3 0 Spt5 transcription elongation factor, acidic N-terminal WRKY PF03106.15 ELR15121.1 - 7e-39 131.9 12.4 1.1e-20 73.7 2.5 4.0 4 0 0 4 4 4 2 WRKY DNA -binding domain TFIIA PF03153.13 ELR15121.1 - 4.2e-05 23.7 20.7 4.2e-05 23.7 20.7 3.6 2 2 1 3 3 3 1 Transcription factor IIA, alpha/beta subunit DUF1283 PF06932.11 ELR15121.1 - 0.0024 18.1 4.1 0.01 16.0 4.1 2.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1283) Pkinase_Tyr PF07714.17 ELR15122.1 - 6.9e-65 218.9 0.0 9.2e-65 218.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ELR15122.1 - 6.5e-57 192.9 0.0 9.1e-57 192.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Haspin_kinase PF12330.8 ELR15122.1 - 0.0013 17.7 0.1 0.011 14.7 0.0 2.0 2 0 0 2 2 2 1 Haspin like kinase domain Kinase-like PF14531.6 ELR15122.1 - 0.022 14.1 0.0 0.036 13.4 0.0 1.2 1 0 0 1 1 1 0 Kinase-like APH PF01636.23 ELR15122.1 - 0.029 14.3 0.1 0.072 13.0 0.1 1.7 1 1 0 1 1 1 0 Phosphotransferase enzyme family Ribonucleas_3_3 PF14622.6 ELR15123.1 - 8e-45 152.1 0.0 1.5e-25 89.8 0.0 3.4 3 0 0 3 3 3 3 Ribonuclease-III-like Ribonuclease_3 PF00636.26 ELR15123.1 - 2.3e-36 124.6 0.0 1.2e-16 61.2 0.0 3.1 3 1 0 3 3 3 2 Ribonuclease III domain dsrm PF00035.26 ELR15123.1 - 3.5e-13 50.1 0.0 1.2e-07 32.3 0.0 2.5 2 0 0 2 2 2 2 Double-stranded RNA binding motif PAZ PF02170.22 ELR15123.1 - 1.1e-09 38.2 0.0 2.1e-09 37.3 0.0 1.3 1 0 0 1 1 1 1 PAZ domain DND1_DSRM PF14709.7 ELR15123.1 - 0.00068 19.8 0.3 2.3 8.5 0.0 2.9 2 1 0 2 2 2 2 double strand RNA binding domain from DEAD END PROTEIN 1 Baculo_PEP_C PF04513.12 ELR15124.1 - 0.00026 21.0 8.6 0.00048 20.2 4.7 2.1 1 1 1 2 2 2 2 Baculovirus polyhedron envelope protein, PEP, C terminus DUF3659 PF12396.8 ELR15124.1 - 0.0011 18.8 0.8 0.0057 16.5 0.8 2.2 1 1 0 1 1 1 1 Protein of unknown function (DUF3659) TetR_C_20 PF17925.1 ELR15124.1 - 0.038 14.3 0.0 0.17 12.2 0.0 2.1 1 1 1 2 2 2 0 Tetracyclin repressor-like, C-terminal domain TFCD_C PF12612.8 ELR15124.1 - 0.49 10.2 2.7 1.1 9.1 2.6 1.5 1 1 0 1 1 1 0 Tubulin folding cofactor D C terminal AIRS PF00586.24 ELR15125.1 - 2.3e-22 79.4 1.1 8.3e-22 77.7 0.4 2.2 2 0 0 2 2 2 1 AIR synthase related protein, N-terminal domain AIRS_C PF02769.22 ELR15125.1 - 1.3e-18 67.6 2.6 7.8e-11 42.3 0.1 2.3 2 0 0 2 2 2 2 AIR synthase related protein, C-terminal domain Trypan_PARP PF05887.11 ELR15125.1 - 0.019 14.9 17.2 0.035 14.1 17.2 1.4 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) Aminotran_5 PF00266.19 ELR15126.1 - 5.8e-63 213.1 0.4 4.4e-55 187.1 0.1 2.1 2 0 0 2 2 2 2 Aminotransferase class-V Beta_elim_lyase PF01212.21 ELR15126.1 - 5.6e-09 35.7 0.5 9.7e-09 34.9 0.2 1.5 2 0 0 2 2 2 1 Beta-eliminating lyase Aminotran_1_2 PF00155.21 ELR15126.1 - 2.7e-06 26.8 0.0 2.1e-05 23.9 0.0 1.9 2 0 0 2 2 2 1 Aminotransferase class I and II Pkinase PF00069.25 ELR15127.1 - 2.1e-41 142.1 0.0 2.9e-41 141.6 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR15127.1 - 1.2e-20 74.0 0.0 1.8e-20 73.3 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase RRM_1 PF00076.22 ELR15127.1 - 3.1e-10 39.7 0.0 0.0011 18.8 0.0 2.8 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 ELR15127.1 - 8.3e-08 31.9 0.0 0.008 15.8 0.0 2.8 1 1 1 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 ELR15127.1 - 0.016 15.1 0.1 0.079 12.8 0.0 2.1 3 0 0 3 3 3 0 Occluded RNA-recognition motif ArlS_N PF18719.1 ELR15127.1 - 0.051 13.8 0.3 0.58 10.4 0.1 2.4 2 0 0 2 2 2 0 ArlS sensor domain Ras PF00071.22 ELR15128.1 - 2.4e-13 50.0 0.0 1.6e-09 37.6 0.0 2.4 2 0 0 2 2 2 2 Ras family Roc PF08477.13 ELR15128.1 - 2.4e-10 40.7 0.0 1e-09 38.6 0.0 2.0 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR15128.1 - 0.0016 17.9 0.0 0.0041 16.6 0.0 1.6 1 0 0 1 1 1 1 ADP-ribosylation factor family AAA_7 PF12775.7 ELR15128.1 - 0.068 12.7 0.0 0.14 11.6 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region UPF0086 PF01868.16 ELR15129.1 - 3.4e-07 30.1 0.0 3.8e-07 29.9 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function UPF0086 HgmA PF04209.13 ELR15130.1 - 2e-217 721.9 0.2 2.3e-217 721.7 0.2 1.0 1 0 0 1 1 1 1 homogentisate 1,2-dioxygenase TFIIA PF03153.13 ELR15131.1 - 0.097 12.7 23.4 0.14 12.2 6.5 2.1 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit CENP-B_dimeris PF09026.10 ELR15131.1 - 0.1 13.0 14.2 0.25 11.8 14.2 1.7 1 0 0 1 1 1 0 Centromere protein B dimerisation domain DNA_pol_phi PF04931.13 ELR15131.1 - 1.2 7.2 12.0 2 6.4 12.0 1.3 1 0 0 1 1 1 0 DNA polymerase phi Cwf_Cwc_15 PF04889.12 ELR15131.1 - 4.7 6.9 22.2 0.24 11.1 9.8 2.2 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein P2X_receptor PF00864.19 ELR15132.1 - 1.5e-13 50.6 2.5 1.3e-06 27.7 0.1 3.1 3 0 0 3 3 3 3 ATP P2X receptor IPK PF03770.16 ELR15133.1 - 5.4e-45 153.7 0.0 1.1e-44 152.7 0.0 1.5 1 1 0 1 1 1 1 Inositol polyphosphate kinase EF-hand_8 PF13833.6 ELR15133.1 - 9.1e-10 38.2 1.9 0.00035 20.4 0.0 2.9 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_1 PF00036.32 ELR15133.1 - 1e-08 34.1 9.5 6e-06 25.4 0.1 4.2 4 0 0 4 4 4 2 EF hand EF-hand_7 PF13499.6 ELR15133.1 - 1.2e-07 32.0 6.4 0.00095 19.6 0.0 3.7 2 2 1 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.6 ELR15133.1 - 1.6e-07 30.5 0.1 1.6e-07 30.5 0.1 2.7 2 0 0 2 2 2 1 EF hand EF-hand_6 PF13405.6 ELR15133.1 - 2e-07 30.4 7.3 0.0002 21.0 0.0 4.0 4 0 0 4 4 4 2 EF-hand domain DUF3093 PF11292.8 ELR15133.1 - 0.039 14.2 14.4 0.22 11.8 10.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3093) CitMHS PF03600.16 ELR15133.1 - 0.062 12.5 0.0 0.063 12.5 0.0 1.2 1 0 0 1 1 1 0 Citrate transporter SP_C-Propep PF08999.10 ELR15133.1 - 0.081 12.7 4.0 0.092 12.5 2.3 1.9 2 0 0 2 2 2 0 Surfactant protein C, N terminal propeptide Shisa PF13908.6 ELR15133.1 - 0.11 12.8 0.1 0.19 11.9 0.1 1.3 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator PRIMA1 PF16101.5 ELR15133.1 - 0.13 12.3 0.5 0.28 11.2 0.5 1.5 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 Baculo_F PF12259.8 ELR15133.1 - 0.16 10.5 0.2 0.28 9.7 0.2 1.3 1 0 0 1 1 1 0 Baculovirus F protein PBP1_TM PF14812.6 ELR15133.1 - 0.71 10.3 2.4 2.1 8.8 0.0 2.8 3 0 0 3 3 3 0 Transmembrane domain of transglycosylase PBP1 at N-terminal LRR19-TM PF15176.6 ELR15133.1 - 1.2 9.2 3.4 2.6 8.1 3.4 1.6 1 0 0 1 1 1 0 Leucine-rich repeat family 19 TM domain DUF3040 PF11239.8 ELR15133.1 - 2.2 8.6 6.9 4.4 7.6 6.4 1.7 2 0 0 2 2 1 0 Protein of unknown function (DUF3040) AAA_16 PF13191.6 ELR15134.1 - 0.00013 22.4 0.0 0.00019 21.9 0.0 1.3 1 0 0 1 1 1 1 AAA ATPase domain PRK PF00485.18 ELR15134.1 - 0.00014 21.6 0.0 0.00039 20.2 0.0 1.7 2 0 0 2 2 2 1 Phosphoribulokinase / Uridine kinase family NB-ARC PF00931.22 ELR15134.1 - 0.0028 16.9 0.0 0.0049 16.1 0.0 1.3 1 0 0 1 1 1 1 NB-ARC domain Zeta_toxin PF06414.12 ELR15134.1 - 0.0035 16.6 0.0 0.0055 16.0 0.0 1.3 1 0 0 1 1 1 1 Zeta toxin AAA_24 PF13479.6 ELR15134.1 - 0.0049 16.6 0.0 0.0079 15.9 0.0 1.3 1 0 0 1 1 1 1 AAA domain ABC_tran PF00005.27 ELR15134.1 - 0.0072 16.8 0.0 0.012 16.1 0.0 1.4 1 0 0 1 1 1 1 ABC transporter AAA_33 PF13671.6 ELR15134.1 - 0.0085 16.3 0.0 0.02 15.1 0.0 1.6 1 1 0 1 1 1 1 AAA domain Cytidylate_kin PF02224.18 ELR15134.1 - 0.014 15.1 0.1 0.023 14.4 0.1 1.3 1 0 0 1 1 1 0 Cytidylate kinase AAA PF00004.29 ELR15134.1 - 0.018 15.5 0.0 0.035 14.5 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Rad17 PF03215.15 ELR15134.1 - 0.02 14.8 0.0 0.04 13.8 0.0 1.5 2 0 0 2 2 2 0 Rad17 P-loop domain AAA_18 PF13238.6 ELR15134.1 - 0.022 15.3 0.0 0.035 14.6 0.0 1.3 1 0 0 1 1 1 0 AAA domain Myosin_head PF00063.21 ELR15134.1 - 0.024 12.9 0.0 0.032 12.5 0.0 1.1 1 0 0 1 1 1 0 Myosin head (motor domain) RsgA_GTPase PF03193.16 ELR15134.1 - 0.029 14.3 0.0 0.05 13.5 0.0 1.3 1 0 0 1 1 1 0 RsgA GTPase AAA_22 PF13401.6 ELR15134.1 - 0.044 14.0 0.0 0.081 13.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain Parvo_NS1 PF01057.17 ELR15134.1 - 0.05 12.7 0.0 0.075 12.1 0.0 1.2 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 AAA_5 PF07728.14 ELR15134.1 - 0.05 13.6 0.0 0.091 12.8 0.0 1.6 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.21 ELR15134.1 - 0.052 12.9 0.0 0.075 12.4 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI NTPase_1 PF03266.15 ELR15134.1 - 0.062 13.2 0.8 0.16 11.9 0.1 1.9 2 0 0 2 2 2 0 NTPase AAA_30 PF13604.6 ELR15134.1 - 0.071 12.8 0.4 0.14 11.8 0.0 1.6 2 0 0 2 2 2 0 AAA domain APS_kinase PF01583.20 ELR15134.1 - 0.081 12.8 0.0 0.13 12.2 0.0 1.3 1 0 0 1 1 1 0 Adenylylsulphate kinase AAA_7 PF12775.7 ELR15134.1 - 0.082 12.4 0.0 0.17 11.4 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region TIP49 PF06068.13 ELR15134.1 - 0.097 11.9 0.0 0.13 11.4 0.0 1.1 1 0 0 1 1 1 0 TIP49 P-loop domain TniB PF05621.11 ELR15134.1 - 0.1 12.0 0.0 0.49 9.8 0.0 1.8 2 0 0 2 2 2 0 Bacterial TniB protein TsaE PF02367.17 ELR15134.1 - 0.11 12.5 0.0 0.21 11.6 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE CPT PF07931.12 ELR15134.1 - 0.16 11.8 0.0 0.24 11.2 0.0 1.3 1 0 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein AAA_PrkA PF08298.11 ELR15134.1 - 0.18 10.7 0.0 0.25 10.2 0.0 1.1 1 0 0 1 1 1 0 PrkA AAA domain PRK PF00485.18 ELR15135.1 - 4.8e-20 72.1 5.3 2.6e-19 69.7 1.6 2.6 2 1 0 2 2 2 1 Phosphoribulokinase / Uridine kinase family AAA_16 PF13191.6 ELR15135.1 - 0.00018 21.9 0.0 0.00034 21.0 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain Zeta_toxin PF06414.12 ELR15135.1 - 0.008 15.5 0.0 0.021 14.1 0.0 1.7 1 0 0 1 1 1 1 Zeta toxin AAA_18 PF13238.6 ELR15135.1 - 0.0086 16.6 0.0 0.02 15.4 0.0 1.7 1 0 0 1 1 1 1 AAA domain NB-ARC PF00931.22 ELR15135.1 - 0.0097 15.1 0.0 0.016 14.4 0.0 1.3 1 0 0 1 1 1 1 NB-ARC domain AAA_24 PF13479.6 ELR15135.1 - 0.0097 15.6 0.0 0.019 14.7 0.0 1.5 1 0 0 1 1 1 1 AAA domain ABC_tran PF00005.27 ELR15135.1 - 0.017 15.7 0.0 0.046 14.2 0.0 1.7 1 0 0 1 1 1 0 ABC transporter AAA_33 PF13671.6 ELR15135.1 - 0.029 14.5 0.0 0.08 13.1 0.0 1.8 2 0 0 2 2 2 0 AAA domain Cytidylate_kin PF02224.18 ELR15135.1 - 0.049 13.3 0.3 0.087 12.6 0.3 1.3 1 0 0 1 1 1 0 Cytidylate kinase AAA PF00004.29 ELR15135.1 - 0.056 13.9 0.0 0.12 12.8 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Rad17 PF03215.15 ELR15135.1 - 0.07 13.0 0.0 0.15 12.0 0.0 1.5 1 0 0 1 1 1 0 Rad17 P-loop domain RsgA_GTPase PF03193.16 ELR15135.1 - 0.072 13.0 0.0 0.18 11.7 0.0 1.6 1 0 0 1 1 1 0 RsgA GTPase AAA_22 PF13401.6 ELR15135.1 - 0.08 13.2 0.0 0.26 11.6 0.0 1.8 2 0 0 2 2 1 0 AAA domain Myosin_head PF00063.21 ELR15135.1 - 0.084 11.1 0.0 0.12 10.6 0.0 1.1 1 0 0 1 1 1 0 Myosin head (motor domain) AAA_5 PF07728.14 ELR15135.1 - 0.15 12.0 0.0 0.35 10.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) Parvo_NS1 PF01057.17 ELR15135.1 - 0.15 11.1 0.0 0.29 10.2 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 CorA PF01544.18 ELR15136.1 - 4.1e-09 36.2 1.0 8.7e-09 35.1 1.0 1.4 1 1 0 1 1 1 1 CorA-like Mg2+ transporter protein SHE3 PF17078.5 ELR15136.1 - 0.0061 16.3 0.4 0.011 15.5 0.2 1.4 1 1 0 1 1 1 1 SWI5-dependent HO expression protein 3 BLOC1_2 PF10046.9 ELR15136.1 - 0.077 13.3 1.1 0.62 10.4 0.6 2.2 1 1 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 EMP24_GP25L PF01105.24 ELR15136.1 - 0.13 12.1 1.0 0.25 11.2 0.8 1.5 1 1 0 1 1 1 0 emp24/gp25L/p24 family/GOLD Fib_alpha PF08702.10 ELR15136.1 - 0.26 11.5 2.2 0.48 10.6 2.2 1.3 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family MIF4G PF02854.19 ELR15137.1 - 8.2e-50 169.4 1.0 8.2e-50 169.4 1.0 2.3 2 1 0 2 2 2 1 MIF4G domain MA3 PF02847.17 ELR15137.1 - 3.5e-20 72.1 2.6 6.2e-20 71.3 0.8 2.3 3 0 0 3 3 3 1 MA3 domain Rrn6 PF10214.9 ELR15137.1 - 0.23 9.9 0.2 0.36 9.3 0.2 1.2 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor Pneumo_att_G PF05539.11 ELR15138.1 - 5.1 6.6 11.3 6.2 6.3 11.3 1.1 1 0 0 1 1 1 0 Pneumovirinae attachment membrane glycoprotein G SelP_N PF04592.14 ELR15139.1 - 0.67 9.3 17.1 0.73 9.2 17.1 1.0 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Zip PF02535.22 ELR15139.1 - 9.1 5.4 8.1 9.4 5.3 8.1 1.0 1 0 0 1 1 1 0 ZIP Zinc transporter LRR_8 PF13855.6 ELR15140.1 - 3.8e-24 84.2 21.9 4e-10 39.3 1.8 4.4 3 1 2 5 5 5 5 Leucine rich repeat LRR_4 PF12799.7 ELR15140.1 - 2.7e-22 78.5 17.3 3.4e-06 27.3 0.4 5.6 4 1 1 5 5 5 5 Leucine Rich repeats (2 copies) C2 PF00168.30 ELR15140.1 - 6.4e-16 58.5 0.1 1.5e-15 57.3 0.1 1.6 1 0 0 1 1 1 1 C2 domain LRR_1 PF00560.33 ELR15140.1 - 6.4e-10 38.2 7.7 0.49 11.1 0.0 8.4 9 0 0 9 9 9 3 Leucine Rich Repeat LRR_9 PF14580.6 ELR15140.1 - 3.4e-06 26.7 4.8 0.011 15.3 0.6 2.7 1 1 0 2 2 2 2 Leucine-rich repeat LRR_6 PF13516.6 ELR15140.1 - 2.2 8.5 21.2 5.8 7.2 0.2 7.0 8 0 0 8 8 8 0 Leucine Rich repeat UCH PF00443.29 ELR15141.1 - 1.6e-40 139.3 0.0 3.5e-40 138.1 0.0 1.6 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 ELR15141.1 - 3.8e-25 89.1 0.0 2.4e-22 79.9 0.0 2.2 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Ipi1_N PF12333.8 ELR15141.1 - 0.094 13.3 0.0 20 5.8 0.0 2.8 2 0 0 2 2 2 0 Rix1 complex component involved in 60S ribosome maturation IMUP PF15761.5 ELR15141.1 - 0.11 13.2 6.4 0.23 12.2 6.4 1.5 1 0 0 1 1 1 0 Immortalisation up-regulated protein SR-25 PF10500.9 ELR15141.1 - 0.29 10.7 3.1 0.48 10.0 3.1 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein LRR_8 PF13855.6 ELR15142.1 - 4.5e-34 116.0 41.4 7.7e-08 32.0 8.0 6.6 2 2 5 7 7 7 6 Leucine rich repeat PP2C PF00481.21 ELR15142.1 - 1.4e-32 113.4 0.0 2.3e-32 112.7 0.0 1.3 1 0 0 1 1 1 1 Protein phosphatase 2C LRR_4 PF12799.7 ELR15142.1 - 7e-31 105.8 37.4 4.6e-06 26.9 0.7 7.2 1 1 8 10 10 10 10 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 ELR15142.1 - 5.1e-07 29.4 25.4 18 6.4 0.0 10.6 8 3 1 9 9 9 2 Leucine Rich Repeat LRR_9 PF14580.6 ELR15142.1 - 2.5e-06 27.1 14.1 0.0078 15.7 3.6 3.7 2 1 2 4 4 4 4 Leucine-rich repeat SpoIIE PF07228.12 ELR15142.1 - 0.0067 16.4 0.1 1.6 8.6 0.0 2.4 2 0 0 2 2 2 2 Stage II sporulation protein E (SpoIIE) Ribosomal_L28e PF01778.17 ELR15143.1 - 3.8e-38 130.8 2.2 7e-38 129.9 2.2 1.4 1 0 0 1 1 1 1 Ribosomal L28e protein family Mak16 PF04874.14 ELR15143.1 - 1.4e-15 57.7 26.4 1.2e-14 54.7 25.9 2.3 1 1 1 2 2 2 1 Mak16 protein C-terminal region DUF4820 PF16091.5 ELR15143.1 - 0.0024 17.3 5.1 0.0042 16.5 5.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4820) Apelin PF15360.6 ELR15143.1 - 0.032 14.8 2.5 0.4 11.3 0.1 3.0 3 0 0 3 3 3 0 APJ endogenous ligand BUD22 PF09073.10 ELR15143.1 - 0.043 13.2 13.9 0.055 12.8 13.9 1.1 1 0 0 1 1 1 0 BUD22 CNDH2_C PF16858.5 ELR15143.1 - 0.11 12.3 10.1 0.17 11.7 10.1 1.2 1 0 0 1 1 1 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term DUF4611 PF15387.6 ELR15143.1 - 0.22 11.8 20.9 0.51 10.6 2.9 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4611) Nop14 PF04147.12 ELR15143.1 - 0.26 9.5 21.4 0.34 9.1 21.4 1.1 1 0 0 1 1 1 0 Nop14-like family Pes-10 PF07149.11 ELR15143.1 - 6.3 5.7 24.1 9.5 5.2 24.1 1.2 1 0 0 1 1 1 0 Pes-10 Formyl_trans_C PF02911.18 ELR15144.1 - 9.8e-10 38.6 0.1 2.6e-08 34.0 0.1 2.1 1 1 0 1 1 1 1 Formyl transferase, C-terminal domain SHE3 PF17078.5 ELR15145.1 - 0.011 15.4 0.0 0.014 15.2 0.0 1.1 1 0 0 1 1 1 0 SWI5-dependent HO expression protein 3 GRAM PF02893.20 ELR15146.1 - 4.6e-09 36.2 0.0 5e-09 36.0 0.0 1.0 1 0 0 1 1 1 1 GRAM domain Formyl_trans_N PF00551.19 ELR15148.1 - 8.5e-09 35.4 0.0 1.4e-08 34.7 0.0 1.3 1 0 0 1 1 1 1 Formyl transferase SAP PF02037.27 ELR15149.1 - 4.2e-08 32.7 2.4 7.3e-08 32.0 2.4 1.4 1 0 0 1 1 1 1 SAP domain RCC1 PF00415.18 ELR15150.1 - 2.1e-77 255.6 14.4 1.4e-13 51.2 0.0 7.3 5 2 2 7 7 7 7 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 ELR15150.1 - 2.3e-22 78.2 40.5 1.5e-09 37.4 0.5 7.6 7 0 0 7 7 7 5 Regulator of chromosome condensation (RCC1) repeat FYVE PF01363.21 ELR15150.1 - 4.9e-21 74.7 8.0 1.2e-20 73.4 8.0 1.7 1 0 0 1 1 1 1 FYVE zinc finger PH_12 PF16457.5 ELR15150.1 - 2.7e-06 27.9 0.0 1.1e-05 25.9 0.0 1.9 1 1 0 1 1 1 1 Pleckstrin homology domain FYVE_2 PF02318.16 ELR15150.1 - 0.033 14.4 7.4 0.064 13.5 7.4 1.5 1 0 0 1 1 1 0 FYVE-type zinc finger Mcp5_PH PF12814.7 ELR15150.1 - 0.033 14.3 0.0 0.06 13.5 0.0 1.4 1 0 0 1 1 1 0 Meiotic cell cortex C-terminal pleckstrin homology DZR PF12773.7 ELR15150.1 - 0.29 11.2 8.5 2.6 8.2 3.0 2.7 2 0 0 2 2 2 0 Double zinc ribbon IBR PF01485.21 ELR15150.1 - 0.77 10.0 6.0 2.2 8.6 6.0 1.8 1 0 0 1 1 1 0 IBR domain, a half RING-finger domain zf-B_box PF00643.24 ELR15150.1 - 9.9 6.4 8.5 3.4 7.9 4.1 2.3 2 0 0 2 2 2 0 B-box zinc finger Ras PF00071.22 ELR15151.1 - 8.9e-48 161.9 0.3 1.7e-19 70.0 0.0 3.0 1 1 2 3 3 3 3 Ras family Roc PF08477.13 ELR15151.1 - 2.2e-33 115.0 0.5 3.3e-11 43.5 0.0 3.0 1 1 2 3 3 3 3 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR15151.1 - 2.2e-05 24.0 0.3 0.3 10.5 0.0 3.0 1 1 2 3 3 3 1 ADP-ribosylation factor family DUF4334 PF14232.6 ELR15151.1 - 0.00086 19.2 0.3 1.9 8.5 0.0 2.4 2 0 0 2 2 2 2 Domain of unknown function (DUF4334) HK_sensor PF16750.5 ELR15151.1 - 0.00096 19.4 0.0 0.35 11.2 0.0 2.3 2 0 0 2 2 2 1 Sensor domain of 2-component histidine kinase MMR_HSR1 PF01926.23 ELR15151.1 - 0.001 19.1 0.2 0.016 15.3 0.2 2.7 1 1 0 1 1 1 1 50S ribosome-binding GTPase DUF4623 PF15416.6 ELR15151.1 - 0.0056 15.3 0.3 0.69 8.4 0.1 2.0 1 1 1 2 2 2 2 Domain of unknown function (DUF4623) Tma16 PF11176.8 ELR15151.1 - 0.0064 16.4 0.0 3.7 7.4 0.0 2.1 2 0 0 2 2 2 2 Translation machinery-associated protein 16 YwhD PF08741.10 ELR15151.1 - 0.013 15.2 0.2 2.6 7.7 0.1 2.1 1 1 1 2 2 2 0 YwhD family DNA_pol_E_B PF04042.16 ELR15151.1 - 0.014 14.7 0.0 2.2 7.6 0.0 2.1 2 0 0 2 2 2 0 DNA polymerase alpha/epsilon subunit B TniB PF05621.11 ELR15151.1 - 0.019 14.4 0.0 0.036 13.5 0.0 1.5 1 0 0 1 1 1 0 Bacterial TniB protein RsgA_GTPase PF03193.16 ELR15151.1 - 0.04 13.8 0.2 0.55 10.1 0.0 2.3 1 1 0 2 2 2 0 RsgA GTPase Exog_C PF18026.1 ELR15151.1 - 0.045 13.8 0.0 16 5.6 0.0 2.3 2 0 0 2 2 2 0 Endo/exonuclease (EXOG) C-terminal domain Glyco_hydro_3_C PF01915.22 ELR15151.1 - 0.059 13.3 0.1 6.5 6.6 0.0 2.1 1 1 1 2 2 2 0 Glycosyl hydrolase family 3 C-terminal domain Viral_cys_rich PF08008.12 ELR15151.1 - 0.084 12.9 0.1 15 5.7 0.0 2.2 1 1 1 2 2 2 0 Viral cysteine rich Pox_A32 PF04665.12 ELR15151.1 - 0.09 12.2 0.0 2.8 7.3 0.0 2.1 2 0 0 2 2 2 0 Poxvirus A32 protein DUF4160 PF13711.6 ELR15151.1 - 0.11 12.9 0.0 22 5.5 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4160) PurL_C PF16904.5 ELR15151.1 - 0.13 12.6 0.1 3 8.2 0.0 2.1 2 0 0 2 2 2 0 Phosphoribosylformylglycinamidine synthase II C-terminus AAA_33 PF13671.6 ELR15151.1 - 0.14 12.3 0.1 4.7 7.4 0.1 2.8 1 1 0 1 1 1 0 AAA domain DUF356 PF04009.12 ELR15151.1 - 0.16 12.3 0.0 4.4 7.6 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF356) Pet191_N PF10203.9 ELR15152.1 - 0.0024 18.1 7.0 0.18 12.2 1.0 2.6 3 0 0 3 3 3 2 Cytochrome c oxidase assembly protein PET191 GCK PF07802.11 ELR15152.1 - 0.016 15.6 1.5 3.6 8.1 0.0 2.6 2 1 0 2 2 2 0 GCK domain CHCH PF06747.13 ELR15152.1 - 0.066 13.4 4.0 17 5.7 0.5 4.8 5 1 1 6 6 6 0 CHCH domain Colipase-like PF15083.6 ELR15152.1 - 0.11 12.6 4.2 0.23 11.6 0.1 2.5 2 2 0 2 2 2 0 Colipase-like Pkinase PF00069.25 ELR15153.1 - 2.5e-44 151.6 0.0 2.5e-43 148.4 0.0 2.1 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR15153.1 - 2.2e-27 96.0 0.0 3.1e-27 95.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pet191_N PF10203.9 ELR15154.1 - 0.00034 20.9 16.6 0.0031 17.8 1.6 3.1 2 1 1 3 3 3 3 Cytochrome c oxidase assembly protein PET191 CHCH PF06747.13 ELR15154.1 - 0.0012 19.0 0.1 0.0012 19.0 0.1 3.5 4 0 0 4 4 4 2 CHCH domain CX9C PF16860.5 ELR15154.1 - 0.041 13.9 13.9 5.3 7.1 0.1 4.3 3 1 1 4 4 4 0 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, DUF3128 PF11326.8 ELR15154.1 - 0.56 10.6 8.4 1.2 9.6 0.2 3.7 1 1 3 4 4 4 0 Protein of unknown function (DUF3128) COX17 PF05051.13 ELR15154.1 - 1.6 9.2 15.7 3.4 8.1 0.6 3.6 2 2 1 3 3 3 0 Cytochrome C oxidase copper chaperone (COX17) MFAP1 PF06991.11 ELR15155.1 - 6.7e-64 215.7 31.2 6.7e-64 215.7 31.2 2.4 2 1 0 2 2 2 1 Microfibril-associated/Pre-mRNA processing Cwf_Cwc_15 PF04889.12 ELR15155.1 - 7.3 6.2 61.6 0.089 12.5 25.6 3.2 3 0 0 3 3 3 0 Cwf15/Cwc15 cell cycle control protein RFX_DNA_binding PF02257.15 ELR15156.1 - 9.4e-18 64.6 0.0 2.4e-17 63.3 0.0 1.7 1 0 0 1 1 1 1 RFX DNA-binding domain JAB PF01398.21 ELR15156.1 - 0.0018 18.3 1.0 0.05 13.6 0.0 2.4 2 0 0 2 2 2 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease SR-25 PF10500.9 ELR15156.1 - 0.014 15.0 13.2 0.014 15.0 13.2 2.5 3 0 0 3 3 3 0 Nuclear RNA-splicing-associated protein Velvet PF11754.8 ELR15156.1 - 0.029 14.3 7.0 0.013 15.5 2.0 2.4 2 0 0 2 2 2 0 Velvet factor DUF3446 PF11928.8 ELR15156.1 - 0.16 12.3 17.9 0.025 14.9 12.5 2.4 2 0 0 2 2 2 0 Early growth response N-terminal domain Pex14_N PF04695.13 ELR15156.1 - 0.22 12.2 12.4 0.62 10.7 5.5 2.5 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Zip PF02535.22 ELR15156.1 - 0.24 10.6 12.6 0.035 13.3 3.6 2.2 2 0 0 2 2 2 0 ZIP Zinc transporter SPX PF03105.19 ELR15156.1 - 0.27 11.1 7.6 0.44 10.4 5.6 2.0 2 0 0 2 2 2 0 SPX domain Neur_chan_memb PF02932.16 ELR15156.1 - 0.31 11.1 2.0 2 8.4 0.3 2.2 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region EPL1 PF10513.9 ELR15156.1 - 0.87 10.0 9.8 0.23 11.8 1.3 2.2 2 0 0 2 2 2 0 Enhancer of polycomb-like TFIIA PF03153.13 ELR15156.1 - 0.92 9.4 12.8 0.5 10.3 5.7 2.2 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Apt1 PF10351.9 ELR15156.1 - 2.5 6.9 6.5 0.15 10.8 1.1 1.6 2 0 0 2 2 2 0 Golgi-body localisation protein domain Hydin_ADK PF17213.3 ELR15156.1 - 4.6 7.5 8.3 2.7 8.2 3.3 2.2 2 0 0 2 2 2 0 Hydin Adenylate kinase-like domain TCP PF03634.13 ELR15156.1 - 6.7 7.3 15.5 15 6.1 9.4 2.5 2 0 0 2 2 2 0 TCP family transcription factor SelP_N PF04592.14 ELR15156.1 - 8.1 5.8 42.7 0.13 11.6 21.6 2.3 2 0 0 2 2 2 0 Selenoprotein P, N terminal region zf-RING_2 PF13639.6 ELR15157.1 - 3e-07 30.7 8.6 7e-07 29.5 8.6 1.7 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 ELR15157.1 - 4e-05 23.4 2.7 8.6e-05 22.3 2.7 1.6 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 ELR15157.1 - 0.00027 20.7 12.0 0.0013 18.6 12.0 2.0 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) ubiquitin PF00240.23 ELR15157.1 - 0.0013 18.4 0.0 0.0024 17.6 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin family zf-RING_5 PF14634.6 ELR15157.1 - 0.0022 17.9 7.7 0.0045 16.9 7.7 1.6 1 1 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_2 PF13923.6 ELR15157.1 - 0.004 17.0 13.2 0.16 11.9 13.2 2.3 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Rad50_zn_hook PF04423.14 ELR15157.1 - 0.0045 16.8 2.1 2.6 7.9 0.1 2.7 2 0 0 2 2 2 2 Rad50 zinc hook motif zf-rbx1 PF12678.7 ELR15157.1 - 0.026 14.8 8.0 0.081 13.2 8.1 1.8 1 1 1 2 2 2 0 RING-H2 zinc finger domain zf-RING_UBOX PF13445.6 ELR15157.1 - 0.068 13.2 5.4 0.3 11.1 5.4 2.2 1 1 0 1 1 1 0 RING-type zinc-finger Prok-RING_4 PF14447.6 ELR15157.1 - 0.12 12.2 8.1 2.1 8.3 5.0 2.3 2 0 0 2 2 2 0 Prokaryotic RING finger family 4 zf-ANAPC11 PF12861.7 ELR15157.1 - 0.58 10.2 3.9 1.1 9.4 3.9 1.5 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_4 PF14570.6 ELR15157.1 - 1.3 8.9 12.0 14 5.6 11.4 2.3 1 1 1 2 2 2 0 RING/Ubox like zinc-binding domain zf-P11 PF03854.14 ELR15157.1 - 4.5 7.0 8.9 17 5.1 5.2 2.3 2 0 0 2 2 2 0 P-11 zinc finger GST_C_3 PF14497.6 ELR15158.1 - 2.2e-19 69.5 0.0 3.1e-19 69.0 0.0 1.2 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 ELR15158.1 - 4.1e-10 39.9 0.0 7.6e-10 39.0 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 ELR15158.1 - 1.3e-09 38.2 0.4 3.8e-08 33.4 0.0 2.2 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 ELR15158.1 - 9.2e-06 25.6 0.1 2.1e-05 24.5 0.1 1.8 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 ELR15158.1 - 0.0067 16.8 0.0 0.014 15.8 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 ELR15158.1 - 0.057 13.7 0.0 0.1 12.9 0.0 1.4 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain Porin_3 PF01459.22 ELR15159.1 - 1.7e-33 116.3 0.0 3e-33 115.4 0.0 1.4 1 1 0 1 1 1 1 Eukaryotic porin DUF4219 PF13961.6 ELR15159.1 - 0.034 13.8 0.3 0.081 12.6 0.3 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4219) VPS9 PF02204.18 ELR15160.1 - 1.7e-25 89.2 0.0 2.7e-25 88.6 0.0 1.3 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain ACTH_assoc PF16102.5 ELR15160.1 - 0.12 13.2 7.7 0.56 11.1 0.8 3.5 2 0 0 2 2 2 0 ACTH-associated domain RasGEF PF00617.19 ELR15161.1 - 1.7e-26 93.5 0.3 2.6e-26 92.9 0.3 1.3 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 ELR15161.1 - 5e-18 65.3 0.0 1.2e-17 64.0 0.0 1.6 1 0 0 1 1 1 1 RasGEF N-terminal motif F-box-like PF12937.7 ELR15161.1 - 6e-13 48.5 1.2 1.7e-12 47.0 1.2 1.9 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ELR15161.1 - 1.7e-09 37.3 0.5 4.6e-09 35.9 0.5 1.8 1 0 0 1 1 1 1 F-box domain RPA_interact_M PF14767.6 ELR15161.1 - 0.052 14.1 0.1 12 6.5 0.0 2.4 2 0 0 2 2 2 0 Replication protein A interacting middle AAA_23 PF13476.6 ELR15162.1 - 0.094 13.2 1.2 0.13 12.7 1.2 1.2 1 0 0 1 1 1 0 AAA domain Cgr1 PF03879.14 ELR15162.1 - 0.35 11.3 10.2 0.64 10.4 10.2 1.4 1 0 0 1 1 1 0 Cgr1 family GTP_EFTU PF00009.27 ELR15163.1 - 2.4e-46 157.7 0.0 3.7e-46 157.1 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_C PF00679.24 ELR15163.1 - 3.3e-16 59.1 0.0 6.4e-16 58.2 0.0 1.5 1 0 0 1 1 1 1 Elongation factor G C-terminus MMR_HSR1 PF01926.23 ELR15163.1 - 3.8e-06 27.0 0.1 9.3e-06 25.7 0.1 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU_D2 PF03144.25 ELR15163.1 - 8.4e-06 26.1 2.0 1.4e-05 25.4 0.7 2.1 2 0 0 2 2 2 1 Elongation factor Tu domain 2 Septin PF00735.18 ELR15163.1 - 0.00029 20.2 0.1 0.00049 19.5 0.1 1.3 1 0 0 1 1 1 1 Septin FeoB_N PF02421.18 ELR15163.1 - 0.0084 15.6 0.1 0.078 12.5 0.1 2.6 1 1 0 1 1 1 1 Ferrous iron transport protein B SRPRB PF09439.10 ELR15163.1 - 0.013 14.9 0.0 0.024 14.1 0.0 1.4 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit EFG_II PF14492.6 ELR15163.1 - 0.12 12.5 0.0 0.23 11.6 0.0 1.5 1 0 0 1 1 1 0 Elongation Factor G, domain II Pkinase PF00069.25 ELR15165.1 - 7.4e-65 218.9 0.0 1.2e-64 218.3 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR15165.1 - 6.9e-46 156.6 0.0 9.8e-46 156.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase DEP PF00610.21 ELR15165.1 - 3.4e-10 39.8 0.0 8e-10 38.6 0.0 1.6 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) Pkinase_fungal PF17667.1 ELR15165.1 - 1.2e-08 34.2 2.5 2.1e-08 33.4 0.1 2.0 2 0 0 2 2 2 1 Fungal protein kinase Kinase-like PF14531.6 ELR15165.1 - 4.9e-06 26.1 0.2 0.0038 16.6 0.0 2.5 3 0 0 3 3 3 2 Kinase-like Haspin_kinase PF12330.8 ELR15165.1 - 0.0011 18.0 0.4 0.0065 15.5 0.4 2.2 1 1 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 ELR15165.1 - 0.0026 17.1 0.1 0.0053 16.1 0.1 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 ELR15165.1 - 0.12 12.3 0.2 0.67 9.8 0.1 2.2 2 1 1 3 3 3 0 Phosphotransferase enzyme family DUF533 PF04391.12 ELR15165.1 - 0.37 10.3 3.4 11 5.5 0.2 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF533) SBP_bac_3 PF00497.20 ELR15166.1 - 0.0041 16.6 0.0 2 7.8 0.0 2.2 2 0 0 2 2 2 2 Bacterial extracellular solute-binding proteins, family 3 YchF-GTPase_C PF06071.13 ELR15167.1 - 1e-31 108.9 1.3 2.4e-31 107.8 1.3 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF933) MMR_HSR1 PF01926.23 ELR15167.1 - 2.8e-22 78.9 0.0 9.4e-22 77.2 0.0 1.9 1 1 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 ELR15167.1 - 8.5e-07 28.6 0.0 1.9e-06 27.5 0.0 1.5 1 0 0 1 1 1 1 Ferrous iron transport protein B TGS PF02824.21 ELR15167.1 - 0.00033 20.7 0.6 0.0016 18.4 0.6 2.1 1 1 0 1 1 1 1 TGS domain MeaB PF03308.16 ELR15167.1 - 0.0024 16.9 0.0 0.0047 15.9 0.0 1.4 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB Tmemb_14 PF03647.13 ELR15168.1 - 9.9e-20 71.1 15.2 1.1e-19 70.9 15.2 1.0 1 0 0 1 1 1 1 Transmembrane proteins 14C Bac_rhodopsin PF01036.18 ELR15168.1 - 0.055 13.0 6.4 0.07 12.7 6.4 1.2 1 0 0 1 1 1 0 Bacteriorhodopsin-like protein CbtA PF09490.10 ELR15168.1 - 0.43 10.3 6.8 0.23 11.2 5.0 1.5 1 1 0 1 1 1 0 Probable cobalt transporter subunit (CbtA) MerC PF03203.14 ELR15168.1 - 1.2 9.6 9.7 10 6.6 9.8 1.9 1 1 0 1 1 1 0 MerC mercury resistance protein Peptidase_M1 PF01433.20 ELR15170.1 - 4.5e-29 101.6 2.8 9.9e-29 100.5 2.8 1.6 1 0 0 1 1 1 1 Peptidase family M1 domain HEAT_2 PF13646.6 ELR15170.1 - 3.7e-15 56.1 7.9 7.1e-05 23.1 0.2 4.3 3 0 0 3 3 3 3 HEAT repeats Peptidase_M1_N PF17900.1 ELR15170.1 - 4.1e-12 46.7 0.0 7.9e-12 45.7 0.0 1.5 1 0 0 1 1 1 1 Peptidase M1 N-terminal domain zf-rbx1 PF12678.7 ELR15170.1 - 2e-06 28.0 1.5 4.9e-06 26.7 1.5 1.6 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_2 PF13639.6 ELR15170.1 - 1.1e-05 25.7 3.1 2.4e-05 24.6 3.1 1.5 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 ELR15170.1 - 5.4e-05 23.0 2.4 0.00011 22.0 2.4 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 ELR15170.1 - 0.0002 21.2 0.9 0.00037 20.3 0.9 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_3 PF13920.6 ELR15170.1 - 0.0012 18.7 1.9 0.0021 17.9 1.9 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 ELR15170.1 - 0.0013 18.5 4.5 0.003 17.4 4.5 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) DUF3458 PF11940.8 ELR15170.1 - 0.0026 18.2 0.3 0.0064 16.9 0.0 1.8 2 0 0 2 2 1 1 Domain of unknown function (DUF3458) Ig-like fold zf-RING_5 PF14634.6 ELR15170.1 - 0.026 14.5 2.9 0.054 13.5 2.9 1.5 1 0 0 1 1 1 0 zinc-RING finger domain Baculo_IE-1 PF05290.11 ELR15170.1 - 0.047 13.6 1.0 0.087 12.8 1.0 1.3 1 0 0 1 1 1 0 Baculovirus immediate-early protein (IE-0) Cnd1 PF12717.7 ELR15170.1 - 0.048 13.7 0.0 0.091 12.8 0.0 1.4 1 0 0 1 1 1 0 non-SMC mitotic condensation complex subunit 1 zf-RING_4 PF14570.6 ELR15170.1 - 0.082 12.7 1.7 0.19 11.6 1.7 1.6 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-RING_6 PF14835.6 ELR15170.1 - 0.13 12.2 0.4 0.32 10.9 0.4 1.6 1 0 0 1 1 1 0 zf-RING of BARD1-type protein zf-RING_10 PF16685.5 ELR15170.1 - 0.14 12.3 1.2 0.3 11.3 1.2 1.4 1 0 0 1 1 1 0 zinc RING finger of MSL2 Adaptin_N PF01602.20 ELR15170.1 - 0.22 10.0 0.0 0.43 9.1 0.0 1.3 1 0 0 1 1 1 0 Adaptin N terminal region TSC22 PF01166.18 ELR15170.1 - 0.27 11.6 1.8 1.7 9.0 1.0 2.4 2 0 0 2 2 2 0 TSC-22/dip/bun family LCD1 PF09798.9 ELR15170.1 - 0.68 8.4 2.2 1.3 7.4 0.1 2.0 2 0 0 2 2 2 0 DNA damage checkpoint protein XhlA PF10779.9 ELR15170.1 - 1.7 8.9 3.8 5.5 7.3 3.8 1.9 1 0 0 1 1 1 0 Haemolysin XhlA zf-C3HC4_4 PF15227.6 ELR15170.1 - 2.6 8.3 6.2 6.7 7.0 6.2 1.7 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING PAPS_reduct PF01507.19 ELR15171.1 - 1.6e-24 86.9 0.0 1.2e-21 77.5 0.0 2.5 1 1 0 1 1 1 1 Phosphoadenosine phosphosulfate reductase family DUF1702 PF08012.11 ELR15171.1 - 0.056 12.3 0.1 0.074 11.9 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1702) Acetone_carb_G PF08882.11 ELR15171.1 - 0.082 13.1 0.8 0.22 11.7 0.0 1.9 1 1 1 2 2 2 0 Acetone carboxylase gamma subunit AhpC-TSA PF00578.21 ELR15173.1 - 6.1e-38 129.5 0.0 6.9e-38 129.4 0.0 1.0 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 ELR15173.1 - 1e-23 83.6 0.0 1.2e-23 83.5 0.0 1.0 1 0 0 1 1 1 1 Redoxin AhpC-TSA_2 PF13911.6 ELR15173.1 - 0.00047 20.3 0.0 0.00063 19.8 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA antioxidant enzyme DUF899 PF05988.12 ELR15173.1 - 0.00073 19.1 0.0 0.00091 18.8 0.0 1.1 1 0 0 1 1 1 1 Bacterial protein of unknown function (DUF899) SCO1-SenC PF02630.14 ELR15173.1 - 0.0029 17.5 0.0 0.0035 17.2 0.0 1.2 1 0 0 1 1 1 1 SCO1/SenC Adaptin_N PF01602.20 ELR15174.1 - 1.9e-150 501.9 17.7 2.6e-150 501.5 17.7 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 ELR15174.1 - 6e-61 205.2 17.4 5.3e-29 101.3 0.2 4.6 4 1 0 4 4 4 4 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 ELR15174.1 - 8.9e-18 64.5 6.0 6.9e-07 29.6 0.0 6.3 4 2 2 6 6 6 3 HEAT repeats B2-adapt-app_C PF09066.10 ELR15174.1 - 1.4e-10 41.2 0.0 4.7e-10 39.5 0.0 1.9 1 0 0 1 1 1 1 Beta2-adaptin appendage, C-terminal sub-domain HEAT PF02985.22 ELR15174.1 - 2.7e-06 27.2 10.1 0.087 13.1 0.1 7.1 7 0 0 7 7 7 2 HEAT repeat Cnd3 PF12719.7 ELR15174.1 - 9.8e-06 25.0 2.6 0.00017 20.9 1.0 2.9 2 0 0 2 2 2 1 Nuclear condensing complex subunits, C-term domain CLASP_N PF12348.8 ELR15174.1 - 5.6e-05 22.8 2.1 0.12 11.9 0.0 3.3 3 1 0 3 3 3 2 CLASP N terminal RTP1_C1 PF10363.9 ELR15174.1 - 0.00021 21.5 7.6 4.8 7.4 0.1 5.6 3 2 1 5 5 5 1 Required for nuclear transport of RNA pol II C-terminus 1 Arm PF00514.23 ELR15174.1 - 0.027 14.5 8.2 12 6.2 0.0 6.6 7 0 0 7 7 7 0 Armadillo/beta-catenin-like repeat SHE3 PF17078.5 ELR15174.1 - 0.13 11.9 2.7 0.27 10.9 0.7 2.3 2 0 0 2 2 2 0 SWI5-dependent HO expression protein 3 Ank_4 PF13637.6 ELR15175.1 - 1.3e-08 35.2 4.6 0.00011 22.7 0.9 1.8 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 ELR15175.1 - 1.6e-07 31.4 0.5 1.8e-07 31.3 0.5 1.2 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 ELR15175.1 - 1.1e-06 29.1 0.8 1.3e-06 28.9 0.8 1.2 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.30 ELR15175.1 - 3e-05 24.3 0.2 5.4e-05 23.5 0.2 1.5 1 0 0 1 1 1 1 Ankyrin repeat Ank_3 PF13606.6 ELR15175.1 - 0.00015 21.9 0.2 0.00015 21.9 0.2 1.7 2 0 0 2 2 2 1 Ankyrin repeat B2-adapt-app_C PF09066.10 ELR15176.1 - 9.7e-16 57.9 0.0 4.1e-15 55.9 0.0 1.9 2 0 0 2 2 2 1 Beta2-adaptin appendage, C-terminal sub-domain Suf PF05843.14 ELR15177.1 - 1.3e-61 209.2 8.2 1.1e-58 199.6 0.5 5.2 4 3 1 5 5 5 1 Suppressor of forked protein (Suf) TPR_14 PF13428.6 ELR15177.1 - 9.5e-13 47.8 4.9 0.039 14.8 0.0 7.5 4 2 4 8 8 8 3 Tetratricopeptide repeat TPR_19 PF14559.6 ELR15177.1 - 0.00012 22.5 0.0 0.0014 19.1 0.0 2.8 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_6 PF13174.6 ELR15177.1 - 0.012 16.2 0.5 7.9 7.3 0.0 4.2 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_8 PF13181.6 ELR15177.1 - 0.045 14.0 0.0 22 5.6 0.0 3.7 3 0 0 3 3 3 0 Tetratricopeptide repeat NifW PF03206.14 ELR15177.1 - 0.045 14.3 0.1 3.7 8.1 0.0 2.6 2 0 0 2 2 2 0 Nitrogen fixation protein NifW DUF410 PF04190.13 ELR15177.1 - 0.071 12.9 2.1 0.1 12.4 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF410) TPR_2 PF07719.17 ELR15177.1 - 0.11 12.6 10.0 17 5.8 0.0 6.0 7 0 0 7 7 7 0 Tetratricopeptide repeat Mad3_BUB1_I PF08311.12 ELR15177.1 - 0.65 10.0 8.1 3.7 7.5 0.2 4.6 4 3 2 6 6 6 0 Mad3/BUB1 homology region 1 TPR_16 PF13432.6 ELR15177.1 - 7.9 7.2 8.4 5.7 7.7 0.0 4.4 4 1 0 4 4 4 0 Tetratricopeptide repeat F-box PF00646.33 ELR15178.1 - 5.6e-05 22.9 0.0 0.00012 21.9 0.0 1.4 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 ELR15178.1 - 0.0041 17.0 0.5 0.0086 16.0 0.5 1.6 1 0 0 1 1 1 1 F-box-like F-box_4 PF15966.5 ELR15178.1 - 0.13 12.1 0.1 0.28 11.1 0.1 1.5 1 0 0 1 1 1 0 F-box UQ_con PF00179.26 ELR15179.1 - 1.8e-17 63.3 0.0 2.7e-17 62.7 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Rubella_Capsid PF05750.11 ELR15179.1 - 0.0046 16.6 2.6 0.0067 16.1 2.6 1.2 1 0 0 1 1 1 1 Rubella capsid protein DUF1610 PF07754.11 ELR15179.1 - 0.065 13.2 3.2 0.16 12.0 3.2 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF1610) Pex14_N PF04695.13 ELR15179.1 - 0.16 12.6 5.0 0.27 11.9 5.0 1.4 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF5336 PF17270.2 ELR15179.1 - 0.19 11.3 0.7 0.4 10.3 0.7 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5336) zf-Tim10_DDP PF02953.15 ELR15180.1 - 1.2e-09 37.7 1.0 1.6e-09 37.3 1.0 1.2 1 0 0 1 1 1 1 Tim10/DDP family zinc finger G_glu_transpept PF01019.21 ELR15181.1 - 5.9e-158 526.8 0.1 6.9e-158 526.6 0.1 1.0 1 0 0 1 1 1 1 Gamma-glutamyltranspeptidase PEPCK_GTP PF00821.18 ELR15182.1 - 4.6e-301 996.1 0.0 2.3e-165 549.7 0.0 2.1 2 0 0 2 2 2 2 Phosphoenolpyruvate carboxykinase C-terminal P-loop domain PEPCK_N PF17297.2 ELR15182.1 - 4.9e-171 565.7 0.0 9.2e-100 332.7 0.0 2.2 2 0 0 2 2 2 2 Phosphoenolpyruvate carboxykinase N-terminal domain DUF1580 PF07618.11 ELR15182.1 - 0.1 12.3 0.0 9.9 5.9 0.0 3.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1580) TMEM214 PF10151.9 ELR15183.1 - 5e-14 51.7 7.5 8.4e-09 34.5 0.1 3.2 3 0 0 3 3 3 2 TMEM214, C-terminal, caspase 4 activator Rap_GAP PF02145.15 ELR15184.1 - 5e-55 185.9 0.0 7.8e-55 185.3 0.0 1.2 1 0 0 1 1 1 1 Rap/ran-GAP LIM PF00412.22 ELR15184.1 - 2.8e-20 72.3 13.9 1.1e-10 41.5 0.1 4.3 3 1 0 3 3 3 3 LIM domain CDC45 PF02724.14 ELR15184.1 - 0.23 9.7 8.3 0.33 9.2 8.3 1.1 1 0 0 1 1 1 0 CDC45-like protein TFIIF_alpha PF05793.12 ELR15184.1 - 1.9 7.0 21.7 4.1 5.9 21.7 1.4 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Presenilin PF01080.17 ELR15184.1 - 3.3 6.4 7.5 4.7 5.9 7.5 1.2 1 0 0 1 1 1 0 Presenilin Peptidase_M78 PF06114.13 ELR15185.1 - 0.44 10.5 3.6 0.6 10.0 0.0 2.7 1 1 1 2 2 2 0 IrrE N-terminal-like domain Baculo_gp41 PF04700.12 ELR15185.1 - 2.3 8.0 7.2 6.1 6.6 0.0 3.6 2 2 0 3 3 3 0 Structural glycoprotein p40/gp41 conserved region Hydrolase_4 PF12146.8 ELR15186.1 - 1.9e-13 50.3 0.6 4.4e-09 36.0 0.1 2.3 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 ELR15186.1 - 1.2e-10 41.5 0.0 1.5e-08 34.7 0.0 2.2 1 1 1 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 ELR15186.1 - 1.3e-10 42.2 1.9 2.6e-10 41.3 1.9 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.21 ELR15186.1 - 1.9e-09 37.3 0.0 7e-09 35.5 0.0 1.9 1 1 0 1 1 1 1 Prolyl oligopeptidase family DLH PF01738.18 ELR15186.1 - 0.0028 17.3 0.4 0.11 12.0 0.0 2.7 3 0 0 3 3 3 1 Dienelactone hydrolase family BAAT_C PF08840.11 ELR15186.1 - 0.0058 16.6 0.0 0.011 15.6 0.0 1.4 1 0 0 1 1 1 1 BAAT / Acyl-CoA thioester hydrolase C terminal 3HBOH PF10605.9 ELR15186.1 - 0.0076 14.5 0.1 0.33 9.1 0.0 2.1 2 0 0 2 2 2 1 3HB-oligomer hydrolase (3HBOH) Peptidase_S15 PF02129.18 ELR15186.1 - 0.014 15.0 0.0 0.45 10.0 0.0 2.3 2 0 0 2 2 2 0 X-Pro dipeptidyl-peptidase (S15 family) AXE1 PF05448.12 ELR15186.1 - 0.037 12.7 0.0 0.058 12.1 0.0 1.2 1 0 0 1 1 1 0 Acetyl xylan esterase (AXE1) Esterase PF00756.20 ELR15186.1 - 0.054 13.1 0.1 0.13 11.9 0.1 1.6 1 0 0 1 1 1 0 Putative esterase adh_short PF00106.25 ELR15187.1 - 5.6e-29 101.0 0.6 9.4e-29 100.3 0.6 1.3 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ELR15187.1 - 1e-21 77.6 0.6 1.8e-21 76.8 0.3 1.5 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase AdoHcyase_NAD PF00670.21 ELR15187.1 - 0.0028 17.7 0.2 0.008 16.3 0.2 1.7 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain THF_DHG_CYH_C PF02882.19 ELR15187.1 - 0.0062 15.9 0.0 0.012 15.0 0.0 1.4 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Epimerase PF01370.21 ELR15187.1 - 0.012 15.1 0.0 0.017 14.6 0.0 1.2 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family KR PF08659.10 ELR15187.1 - 0.015 15.2 0.3 0.035 14.0 0.3 1.5 1 0 0 1 1 1 0 KR domain FA_hydroxylase PF04116.13 ELR15188.1 - 1.3e-11 45.0 21.0 1.3e-11 45.0 21.0 1.9 2 0 0 2 2 2 1 Fatty acid hydroxylase superfamily DUF1230 PF06799.11 ELR15188.1 - 0.41 10.8 6.8 0.14 12.3 1.0 2.6 2 1 1 3 3 3 0 Conserved in the green lineage and diatoms 27 ECH_1 PF00378.20 ELR15189.1 - 6.1e-48 163.3 0.4 7.3e-48 163.1 0.4 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 ELR15189.1 - 9.8e-24 84.4 0.3 9.1e-22 78.0 0.1 2.0 1 1 1 2 2 2 2 Enoyl-CoA hydratase/isomerase TFIIB_C_1 PF18542.1 ELR15189.1 - 0.16 12.0 0.5 7.9 6.6 0.0 3.1 4 0 0 4 4 4 0 Transcription factor IIB C-terminal module 1 GST_N_3 PF13417.6 ELR15190.1 - 1.7e-13 50.7 0.0 3.4e-13 49.8 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.20 ELR15190.1 - 4.6e-12 46.1 0.0 1.1e-11 44.9 0.0 1.7 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 ELR15190.1 - 3.1e-09 37.0 0.0 6.3e-09 36.0 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 ELR15190.1 - 8.9e-09 35.5 0.0 1.6e-08 34.7 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 ELR15190.1 - 3e-07 30.5 0.0 6.6e-07 29.4 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Glutaredoxin2_C PF04399.13 ELR15190.1 - 0.026 14.4 0.0 0.044 13.6 0.0 1.3 1 0 0 1 1 1 0 Glutaredoxin 2, C terminal domain LRR_6 PF13516.6 ELR15193.1 - 1.3e-16 59.1 27.1 0.00021 21.1 0.3 8.7 9 1 1 10 10 10 5 Leucine Rich repeat Carm_PH PF17888.1 ELR15193.1 - 1e-06 29.0 0.1 2.6e-06 27.7 0.1 1.7 1 0 0 1 1 1 1 Carmil pleckstrin homology domain LRR_4 PF12799.7 ELR15193.1 - 1.3e-05 25.4 11.5 1.3 9.6 0.1 6.5 5 1 0 5 5 5 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 ELR15193.1 - 1.3e-05 24.8 9.3 0.0033 17.2 0.1 5.9 5 1 0 5 5 5 2 Leucine rich repeat LRR_1 PF00560.33 ELR15193.1 - 0.004 17.5 1.9 1.6e+02 3.5 0.0 6.4 6 2 0 6 6 6 0 Leucine Rich Repeat Apolipoprotein PF01442.18 ELR15193.1 - 0.023 14.6 6.7 0.043 13.7 6.7 1.4 1 0 0 1 1 1 0 Apolipoprotein A1/A4/E domain Rsd_AlgQ PF04353.13 ELR15193.1 - 0.12 12.3 0.3 0.28 11.1 0.3 1.5 1 0 0 1 1 1 0 Regulator of RNA polymerase sigma(70) subunit, Rsd/AlgQ ubiquitin PF00240.23 ELR15194.1 - 1.7e-17 62.9 0.0 1.8e-17 62.9 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 ELR15194.1 - 1.6e-07 31.0 0.0 1.8e-07 30.8 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_4 PF18036.1 ELR15194.1 - 0.005 16.9 0.1 0.039 14.0 0.1 1.9 1 1 0 1 1 1 1 Ubiquitin-like domain Ubiquitin_2 PF14560.6 ELR15194.1 - 0.031 14.7 0.0 0.14 12.7 0.0 1.8 1 1 0 1 1 1 0 Ubiquitin-like domain Glyco_hydro_20 PF00728.22 ELR15195.1 - 4.2e-16 59.3 0.0 2.9e-15 56.5 0.0 1.9 1 1 0 1 1 1 1 Glycosyl hydrolase family 20, catalytic domain Glyco_hydro_20b PF02838.15 ELR15195.1 - 6.8e-07 30.1 0.0 1.5e-06 29.0 0.0 1.6 1 0 0 1 1 1 1 Glycosyl hydrolase family 20, domain 2 ATPase_gene1 PF09527.10 ELR15195.1 - 0.91 9.7 3.1 1.7 8.9 3.1 1.3 1 0 0 1 1 1 0 Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter Thioredoxin PF00085.20 ELR15196.1 - 2e-22 79.1 0.2 2.4e-22 78.8 0.2 1.0 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.6 ELR15196.1 - 7.8e-05 23.1 0.5 0.0014 19.1 0.5 2.0 1 1 0 1 1 1 1 Thioredoxin-like domain OST3_OST6 PF04756.13 ELR15196.1 - 0.00015 21.2 0.0 0.00015 21.2 0.0 1.1 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family Thioredoxin_8 PF13905.6 ELR15196.1 - 0.00036 20.8 0.1 0.00099 19.4 0.1 1.8 1 1 0 1 1 1 1 Thioredoxin-like Thioredoxin_3 PF13192.6 ELR15196.1 - 0.0017 18.3 0.2 0.0026 17.8 0.2 1.3 1 0 0 1 1 1 1 Thioredoxin domain Thioredoxin_7 PF13899.6 ELR15196.1 - 0.0069 16.5 0.1 0.011 15.8 0.1 1.4 1 0 0 1 1 1 1 Thioredoxin-like AhpC-TSA PF00578.21 ELR15196.1 - 0.022 14.7 0.2 0.038 13.9 0.2 1.4 1 1 0 1 1 1 0 AhpC/TSA family Thioredoxin_9 PF14595.6 ELR15196.1 - 0.065 13.0 0.2 0.082 12.7 0.2 1.2 1 0 0 1 1 1 0 Thioredoxin TraF PF13728.6 ELR15196.1 - 0.078 12.8 0.0 0.088 12.6 0.0 1.2 1 0 0 1 1 1 0 F plasmid transfer operon protein Endosulfine PF04667.17 ELR15197.1 - 8.2e-11 41.9 1.5 1.1e-10 41.5 1.5 1.2 1 0 0 1 1 1 1 cAMP-regulated phosphoprotein/endosulfine conserved region RNase_T PF00929.24 ELR15199.1 - 5.1e-29 101.9 0.1 1.2e-28 100.8 0.1 1.5 1 1 0 1 1 1 1 Exonuclease RNA_pol_L_2 PF13656.6 ELR15200.1 - 5.7e-27 93.3 0.1 8.2e-27 92.8 0.1 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain RNA_pol_L PF01193.24 ELR15200.1 - 5.2e-09 35.4 0.0 7.5e-09 34.9 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain Rio2_N PF09202.11 ELR15200.1 - 0.0046 17.2 0.0 0.0077 16.4 0.0 1.4 1 0 0 1 1 1 1 Rio2, N-terminal HeLo PF14479.6 ELR15200.1 - 0.16 11.8 0.0 0.18 11.6 0.0 1.1 1 0 0 1 1 1 0 Prion-inhibition and propagation GST_C_2 PF13410.6 ELR15201.1 - 0.00019 21.4 2.9 0.00021 21.3 0.1 2.3 3 0 0 3 3 3 1 Glutathione S-transferase, C-terminal domain GST_C_6 PF17171.4 ELR15201.1 - 0.0002 21.1 0.0 0.00046 19.9 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 ELR15201.1 - 0.093 13.0 0.0 0.22 11.7 0.0 1.6 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain NDUF_B12 PF08122.12 ELR15202.1 - 0.00056 19.9 0.0 0.00097 19.1 0.0 1.4 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase B12 subunit family Ras PF00071.22 ELR15203.1 - 9e-19 67.6 0.1 1.1e-14 54.3 0.1 2.2 1 1 1 2 2 2 2 Ras family Roc PF08477.13 ELR15203.1 - 2e-13 50.6 0.1 2.7e-13 50.2 0.1 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR15203.1 - 0.0031 17.0 0.1 0.0039 16.6 0.1 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family AAA_16 PF13191.6 ELR15203.1 - 0.014 15.7 0.0 0.017 15.5 0.0 1.2 1 0 0 1 1 1 0 AAA ATPase domain Gtr1_RagA PF04670.12 ELR15203.1 - 0.034 13.5 0.0 0.041 13.2 0.0 1.1 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region SRPRB PF09439.10 ELR15203.1 - 0.039 13.4 0.1 0.059 12.8 0.1 1.2 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit AAA_7 PF12775.7 ELR15203.1 - 0.06 12.9 0.3 0.078 12.5 0.3 1.2 1 0 0 1 1 1 0 P-loop containing dynein motor region MMR_HSR1 PF01926.23 ELR15203.1 - 0.1 12.7 0.2 0.15 12.2 0.2 1.3 1 1 0 1 1 1 0 50S ribosome-binding GTPase LRR_6 PF13516.6 ELR15204.1 - 2.9e-06 26.9 17.5 11 6.4 0.0 11.1 12 0 0 12 12 12 3 Leucine Rich repeat LRR_4 PF12799.7 ELR15204.1 - 4.2e-06 27.0 4.8 11 6.6 0.1 7.9 8 0 0 8 8 8 2 Leucine Rich repeats (2 copies) IMUP PF15761.5 ELR15205.1 - 0.46 11.2 6.0 0.12 13.1 1.7 2.2 2 0 0 2 2 2 0 Immortalisation up-regulated protein SR-25 PF10500.9 ELR15205.1 - 6.8 6.2 8.7 13 5.3 8.7 1.4 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein PCI PF01399.27 ELR15206.1 - 2.9e-14 53.4 0.1 2.9e-14 53.4 0.1 3.0 3 0 0 3 3 3 1 PCI domain DUF2766 PF10964.8 ELR15206.1 - 0.073 13.0 0.0 0.23 11.4 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2766) Prominin PF05478.11 ELR15206.1 - 1.8 6.5 7.3 4.2 5.2 7.3 1.7 1 0 0 1 1 1 0 Prominin Paf1 PF03985.13 ELR15207.1 - 1.7e-68 231.6 1.6 1.9e-68 231.5 1.6 1.0 1 0 0 1 1 1 1 Paf1 Tautomerase_2 PF14552.6 ELR15207.1 - 0.026 14.6 0.0 0.09 12.9 0.0 1.9 2 0 0 2 2 2 0 Tautomerase enzyme COesterase PF00135.28 ELR15208.1 - 3.4e-120 402.4 0.0 4.1e-120 402.0 0.0 1.1 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 ELR15208.1 - 0.00038 20.4 0.0 0.0009 19.2 0.0 1.7 2 0 0 2 2 2 1 alpha/beta hydrolase fold NDK PF00334.19 ELR15210.1 - 3.3e-52 176.1 0.0 4.3e-52 175.7 0.0 1.1 1 0 0 1 1 1 1 Nucleoside diphosphate kinase Ribosomal_L9_N PF01281.19 ELR15211.1 - 1.5e-19 69.3 0.0 4e-19 67.9 0.0 1.8 1 0 0 1 1 1 1 Ribosomal protein L9, N-terminal domain Ribosomal_L9_C PF03948.14 ELR15211.1 - 2.8e-09 37.3 0.3 2.8e-09 37.3 0.3 1.7 2 0 0 2 2 2 1 Ribosomal protein L9, C-terminal domain UreD PF01774.17 ELR15212.1 - 1.8e-58 198.0 0.4 2.3e-58 197.6 0.4 1.1 1 0 0 1 1 1 1 UreD urease accessory protein PH PF00169.29 ELR15213.1 - 1.2e-09 38.6 0.8 6.5e-09 36.3 0.0 2.6 2 1 0 2 2 2 1 PH domain K_channel_TID PF07941.11 ELR15213.1 - 0.24 11.9 3.1 0.61 10.6 3.1 1.7 1 0 0 1 1 1 0 Potassium channel Kv1.4 tandem inactivation domain KRAB PF01352.27 ELR15213.1 - 0.92 9.2 4.0 4 7.2 1.7 3.0 2 0 0 2 2 2 0 KRAB box ARD PF03079.14 ELR15214.1 - 4.4e-39 134.2 0.1 5.5e-39 133.9 0.1 1.1 1 0 0 1 1 1 1 ARD/ARD' family Cupin_2 PF07883.11 ELR15214.1 - 2.4e-10 40.0 0.1 4e-10 39.3 0.1 1.3 1 0 0 1 1 1 1 Cupin domain AraC_binding PF02311.19 ELR15214.1 - 1.6e-06 28.1 0.0 2.6e-06 27.4 0.0 1.3 1 0 0 1 1 1 1 AraC-like ligand binding domain Cupin_1 PF00190.22 ELR15214.1 - 0.025 14.2 0.0 0.037 13.6 0.0 1.2 1 0 0 1 1 1 0 Cupin Cupin_3 PF05899.12 ELR15214.1 - 0.087 12.5 0.0 0.26 11.0 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF861) CdiI PF07262.11 ELR15214.1 - 0.15 11.8 0.0 0.96 9.2 0.0 2.0 2 0 0 2 2 2 0 CDI immunity protein 2OG-FeII_Oxy_5 PF13759.6 ELR15214.1 - 0.17 12.3 0.0 0.38 11.2 0.0 1.6 2 0 0 2 2 2 0 Putative 2OG-Fe(II) oxygenase Cupin_6 PF12852.7 ELR15214.1 - 0.21 11.3 0.0 0.28 10.9 0.0 1.2 1 0 0 1 1 1 0 Cupin Aquarius_N PF16399.5 ELR15215.1 - 5.1e-50 170.4 0.0 9.8e-50 169.4 0.0 1.5 1 0 0 1 1 1 1 Intron-binding protein aquarius N-terminus HA PF03457.14 ELR15215.1 - 7.1e-14 51.9 2.9 1.9e-13 50.5 2.9 1.8 1 0 0 1 1 1 1 Helicase associated domain AAA_11 PF13086.6 ELR15215.1 - 2.9e-12 46.9 0.0 2.9e-12 46.9 0.0 3.4 3 1 0 3 3 2 1 AAA domain AAA_19 PF13245.6 ELR15215.1 - 1.1e-07 32.3 0.0 2e-07 31.5 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 ELR15215.1 - 6.3e-06 26.0 0.0 1.6e-05 24.7 0.0 1.7 2 0 0 2 2 2 1 AAA domain ResIII PF04851.15 ELR15215.1 - 5.6e-05 23.2 0.0 0.00014 21.9 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit PhoH PF02562.16 ELR15215.1 - 0.0023 17.4 0.0 0.0038 16.7 0.0 1.2 1 0 0 1 1 1 1 PhoH-like protein AAA_22 PF13401.6 ELR15215.1 - 0.013 15.8 0.0 0.054 13.8 0.0 2.1 1 1 0 1 1 1 0 AAA domain AAA PF00004.29 ELR15215.1 - 0.019 15.4 0.0 0.039 14.4 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) DEAD PF00270.29 ELR15215.1 - 0.031 14.1 0.0 0.055 13.2 0.0 1.4 1 0 0 1 1 1 0 DEAD/DEAH box helicase ATPase PF06745.13 ELR15215.1 - 0.14 11.5 0.0 0.26 10.6 0.0 1.4 1 0 0 1 1 1 0 KaiC ATF7IP_BD PF16788.5 ELR15215.1 - 1.5 8.9 8.7 4 7.5 8.7 1.7 1 0 0 1 1 1 0 ATF-interacting protein binding domain Haem_bd PF14376.6 ELR15216.1 - 0.076 13.0 1.2 0.093 12.7 0.1 1.6 2 0 0 2 2 2 0 Haem-binding domain Herpes_UL6 PF01763.16 ELR15216.1 - 0.15 10.5 0.0 0.2 10.1 0.0 1.1 1 0 0 1 1 1 0 Herpesvirus UL6 like ATG16 PF08614.11 ELR15216.1 - 2.8 8.1 8.0 0.4 10.9 2.2 2.0 2 0 0 2 2 2 0 Autophagy protein 16 (ATG16) FA_FANCE PF11510.8 ELR15218.1 - 6.8e-18 65.0 3.5 1.9e-10 40.6 0.6 2.0 1 1 1 2 2 2 2 Fanconi Anaemia group E protein FANCE WD40 PF00400.32 ELR15219.1 - 1.6e-40 136.3 9.2 4.5e-06 27.3 0.0 7.5 7 0 0 7 7 7 7 WD domain, G-beta repeat U-box PF04564.15 ELR15219.1 - 1.6e-09 37.8 0.0 3.9e-09 36.5 0.0 1.7 1 0 0 1 1 1 1 U-box domain ANAPC4_WD40 PF12894.7 ELR15219.1 - 7.1e-06 26.2 0.2 0.22 11.8 0.0 4.0 1 1 3 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ELR15219.1 - 0.00022 20.0 0.3 0.059 12.0 0.1 3.1 2 1 1 3 3 3 1 Nucleoporin Nup120/160 zf-Nse PF11789.8 ELR15219.1 - 0.001 18.8 0.0 0.0023 17.7 0.0 1.5 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit WD40_like PF17005.5 ELR15219.1 - 0.17 11.2 0.0 0.85 8.9 0.0 2.0 2 0 0 2 2 2 0 WD40-like domain AhpC-TSA_2 PF13911.6 ELR15220.1 - 6.9e-10 39.0 0.1 3.2e-09 36.9 0.1 1.9 1 1 0 1 1 1 1 AhpC/TSA antioxidant enzyme AhpC-TSA PF00578.21 ELR15220.1 - 0.01 15.7 0.0 0.016 15.1 0.0 1.3 1 0 0 1 1 1 0 AhpC/TSA family Redoxin PF08534.10 ELR15220.1 - 0.11 12.3 0.0 0.16 11.7 0.0 1.2 1 0 0 1 1 1 0 Redoxin DWNN PF08783.11 ELR15221.1 - 3.3e-19 68.9 0.4 5.9e-19 68.1 0.4 1.4 1 0 0 1 1 1 1 DWNN domain zf-CCHC PF00098.23 ELR15221.1 - 3.2e-08 33.3 8.3 1.2e-07 31.5 2.5 2.8 2 0 0 2 2 2 1 Zinc knuckle zf-C3HC4_2 PF13923.6 ELR15221.1 - 7.8e-07 28.8 9.1 7.8e-07 28.8 9.1 1.6 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 ELR15221.1 - 3.6e-06 27.2 8.7 6.9e-06 26.3 8.7 1.5 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_3 PF13920.6 ELR15221.1 - 7e-05 22.6 7.7 7e-05 22.6 7.7 1.7 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-CCHC_2 PF13696.6 ELR15221.1 - 0.0034 17.2 12.5 0.0051 16.6 2.1 2.5 2 0 0 2 2 2 1 Zinc knuckle zf-RING_5 PF14634.6 ELR15221.1 - 0.0037 17.2 7.7 0.0092 15.9 7.7 1.7 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4 PF00097.25 ELR15221.1 - 0.0093 15.8 8.4 0.018 14.9 8.4 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_4 PF14570.6 ELR15221.1 - 0.024 14.4 8.3 0.05 13.4 8.3 1.5 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain U-box PF04564.15 ELR15221.1 - 0.037 14.2 0.0 0.081 13.1 0.0 1.6 1 0 0 1 1 1 0 U-box domain zf-RING_10 PF16685.5 ELR15221.1 - 0.085 13.0 5.5 0.15 12.2 5.5 1.4 1 0 0 1 1 1 0 zinc RING finger of MSL2 zf-C3HC4_4 PF15227.6 ELR15221.1 - 0.14 12.3 11.7 0.28 11.4 11.7 1.5 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-rbx1 PF12678.7 ELR15221.1 - 0.4 11.0 4.4 1 9.7 4.4 1.7 1 0 0 1 1 1 0 RING-H2 zinc finger domain zf-RING_UBOX PF13445.6 ELR15221.1 - 0.51 10.4 9.7 1.2 9.2 9.7 1.6 1 0 0 1 1 1 0 RING-type zinc-finger zf-RING_6 PF14835.6 ELR15221.1 - 0.52 10.2 4.2 1 9.3 4.2 1.4 1 0 0 1 1 1 0 zf-RING of BARD1-type protein Pyr_redox_2 PF07992.14 ELR15222.1 - 1.7e-54 185.0 4.3 2.3e-54 184.7 4.3 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 ELR15222.1 - 3.5e-18 65.9 14.2 7.5e-16 58.5 1.5 3.4 3 1 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase Rieske PF00355.26 ELR15222.1 - 1.5e-17 63.3 0.1 3.5e-17 62.1 0.1 1.6 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain Reductase_C PF14759.6 ELR15222.1 - 1.2e-13 51.4 0.3 5.8e-13 49.2 0.0 2.3 3 0 0 3 3 2 1 Reductase C-terminal Pyr_redox_3 PF13738.6 ELR15222.1 - 1.3e-10 41.0 0.7 5.9e-08 32.3 0.0 2.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Rieske_2 PF13806.6 ELR15222.1 - 2.8e-06 27.2 0.0 7.7e-06 25.8 0.0 1.8 1 0 0 1 1 1 1 Rieske-like [2Fe-2S] domain Amino_oxidase PF01593.24 ELR15222.1 - 0.00013 21.4 0.8 0.27 10.5 0.1 3.1 3 0 0 3 3 3 2 Flavin containing amine oxidoreductase HI0933_like PF03486.14 ELR15222.1 - 0.00039 19.3 1.3 0.65 8.6 0.0 3.4 3 1 1 4 4 4 1 HI0933-like protein NAD_binding_8 PF13450.6 ELR15222.1 - 0.0012 19.0 2.7 0.018 15.3 0.3 2.8 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain TrkA_N PF02254.18 ELR15222.1 - 0.0027 18.0 0.6 0.98 9.7 0.0 2.6 2 0 0 2 2 2 1 TrkA-N domain NAD_binding_7 PF13241.6 ELR15222.1 - 0.007 16.8 4.6 2.9 8.4 0.0 3.1 2 2 0 2 2 2 2 Putative NAD(P)-binding Lycopene_cycl PF05834.12 ELR15222.1 - 0.007 15.5 2.9 3.3 6.6 0.0 3.1 2 1 1 3 3 3 2 Lycopene cyclase protein Trp_halogenase PF04820.14 ELR15222.1 - 0.0097 14.8 4.2 1.4 7.7 0.0 2.7 2 1 1 3 3 3 2 Tryptophan halogenase DUF2043 PF09740.9 ELR15222.1 - 0.036 14.7 0.2 0.096 13.4 0.2 1.6 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2043) GIDA PF01134.22 ELR15222.1 - 0.036 13.1 3.1 7.9 5.4 1.0 3.2 2 1 1 3 3 3 0 Glucose inhibited division protein A Sacchrp_dh_NADP PF03435.18 ELR15222.1 - 0.062 13.6 1.0 2.6 8.3 0.0 2.5 2 0 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain DUF1188 PF06690.11 ELR15222.1 - 0.17 11.4 0.0 0.32 10.5 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1188) DAO PF01266.24 ELR15222.1 - 0.39 10.2 12.7 2.5 7.6 0.2 4.2 3 1 1 4 4 4 0 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 ELR15222.1 - 0.65 10.0 4.7 23 5.0 0.1 3.5 3 1 1 4 4 4 0 FAD-NAD(P)-binding Shikimate_DH PF01488.20 ELR15222.1 - 0.73 9.9 5.1 5.6 7.0 0.5 3.0 3 0 0 3 3 3 0 Shikimate / quinate 5-dehydrogenase FAD_binding_2 PF00890.24 ELR15222.1 - 1.2 8.2 13.4 0.12 11.4 0.6 3.6 3 1 1 4 4 3 0 FAD binding domain DUF2151 PF10221.9 ELR15223.1 - 9.6e-42 143.5 2.8 2.4e-29 102.5 0.1 4.3 2 2 0 2 2 2 2 Cell cycle and development regulator DUF1981 PF09324.10 ELR15223.1 - 0.045 13.6 0.1 0.1 12.5 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1981) SRP-alpha_N PF04086.13 ELR15223.1 - 5.3 6.9 8.3 0.36 10.7 1.9 2.1 2 0 0 2 2 2 0 Signal recognition particle, alpha subunit, N-terminal Thioredoxin PF00085.20 ELR15224.1 - 0.0099 15.9 0.0 0.013 15.5 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin DUF3385 PF11865.8 ELR15225.1 - 2.8e-108 358.9 0.2 6.3e-50 169.2 0.0 5.8 5 0 0 5 5 5 2 Domain of unknown function (DUF3385) PI3_PI4_kinase PF00454.27 ELR15225.1 - 6e-71 239.2 0.1 1.4e-70 238.0 0.1 1.7 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase FAT PF02259.23 ELR15225.1 - 3.2e-51 174.6 0.0 2.1e-50 171.9 0.0 2.4 2 1 0 2 2 2 1 FAT domain FRB_dom PF08771.11 ELR15225.1 - 4.3e-43 145.7 0.8 1.9e-42 143.7 0.8 2.3 1 0 0 1 1 1 1 FKBP12-rapamycin binding domain HEAT PF02985.22 ELR15225.1 - 2.7e-29 98.7 22.5 0.00031 20.8 0.0 14.9 15 0 0 15 15 15 6 HEAT repeat HEAT_EZ PF13513.6 ELR15225.1 - 6.9e-25 87.1 26.9 0.00018 21.9 0.2 14.7 13 3 3 16 16 14 5 HEAT-like repeat HEAT_2 PF13646.6 ELR15225.1 - 1.4e-21 76.7 21.7 0.019 15.4 0.2 12.3 6 3 5 11 11 11 7 HEAT repeats FATC PF02260.20 ELR15225.1 - 3.3e-16 58.8 1.4 5.5e-16 58.1 0.1 2.1 2 0 0 2 2 2 1 FATC domain Cnd1 PF12717.7 ELR15225.1 - 1.5e-15 57.7 1.2 0.07 13.2 0.0 7.3 3 2 4 7 7 7 4 non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd PF12755.7 ELR15225.1 - 7.2e-12 45.7 0.0 0.44 11.2 0.0 6.8 7 0 0 7 7 6 3 Vacuolar 14 Fab1-binding region UME PF08064.13 ELR15225.1 - 4.1e-10 39.5 7.0 0.011 15.6 0.0 6.3 6 0 0 6 6 6 3 UME (NUC010) domain Adaptin_N PF01602.20 ELR15225.1 - 2.1e-09 36.5 7.5 0.0006 18.5 0.4 4.5 3 2 0 3 3 3 3 Adaptin N terminal region DUF3730 PF12530.8 ELR15225.1 - 3.5e-09 36.6 1.1 0.028 14.0 0.0 4.7 5 0 0 5 5 3 2 Protein of unknown function (DUF3730) Sec7_N PF12783.7 ELR15225.1 - 1.5e-06 28.2 0.1 0.21 11.5 0.0 4.0 4 0 0 4 4 4 2 Guanine nucleotide exchange factor in Golgi transport N-terminal RTP1_C1 PF10363.9 ELR15225.1 - 1.5e-05 25.1 4.2 12 6.1 0.1 7.8 4 3 5 9 9 9 0 Required for nuclear transport of RNA pol II C-terminus 1 CLASP_N PF12348.8 ELR15225.1 - 1.7e-05 24.5 2.2 1.4 8.4 0.0 7.2 6 2 2 8 8 8 1 CLASP N terminal MMS19_C PF12460.8 ELR15225.1 - 0.00094 18.4 13.4 0.052 12.7 0.7 3.9 4 0 0 4 4 4 2 RNAPII transcription regulator C-terminal Cohesin_HEAT PF12765.7 ELR15225.1 - 0.0072 16.6 2.0 36 4.8 0.0 5.6 5 0 0 5 5 5 0 HEAT repeat associated with sister chromatid cohesion Pas_Saposin PF09016.10 ELR15225.1 - 0.012 15.9 0.1 31 5.0 0.0 4.0 3 0 0 3 3 3 0 Pas factor saposin fold APH PF01636.23 ELR15225.1 - 0.02 14.8 1.2 1.1 9.1 0.0 3.0 2 0 0 2 2 2 0 Phosphotransferase enzyme family Ribosomal_L6 PF00347.23 ELR15225.1 - 0.075 13.7 1.7 80 4.0 0.1 3.4 3 0 0 3 3 3 0 Ribosomal protein L6 Apo-CIII PF05778.12 ELR15225.1 - 0.12 12.0 0.0 33 4.2 0.0 3.0 2 0 0 2 2 2 0 Apolipoprotein CIII (Apo-CIII) RIX1 PF08167.12 ELR15225.1 - 5.7 6.6 12.7 10 5.8 0.1 5.7 5 2 0 5 5 5 0 rRNA processing/ribosome biogenesis DUF4820 PF16091.5 ELR15226.1 - 0.011 15.1 2.0 0.016 14.6 2.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) CNDH2_C PF16858.5 ELR15226.1 - 0.034 14.0 7.3 0.041 13.8 7.3 1.1 1 0 0 1 1 1 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term Cwf_Cwc_15 PF04889.12 ELR15226.1 - 0.087 12.6 16.2 0.11 12.2 16.2 1.1 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein DUF4746 PF15928.5 ELR15226.1 - 0.17 11.3 5.4 0.22 10.9 5.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) DUF1168 PF06658.12 ELR15226.1 - 0.18 11.6 13.9 0.3 10.9 13.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1168) OAD_gamma PF04277.13 ELR15226.1 - 0.35 11.5 5.1 0.66 10.6 4.2 2.0 2 0 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain FYDLN_acid PF09538.10 ELR15226.1 - 0.37 11.5 14.1 0.62 10.8 14.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (FYDLN_acid) CSRNP_N PF16019.5 ELR15226.1 - 0.54 10.1 4.9 0.79 9.6 4.9 1.2 1 0 0 1 1 1 0 Cysteine/serine-rich nuclear protein N-terminus RNA_pol_3_Rpc31 PF11705.8 ELR15226.1 - 0.64 10.2 18.3 0.95 9.7 18.3 1.3 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 TT_ORF2 PF02957.15 ELR15226.1 - 0.82 10.6 5.8 0.39 11.6 3.0 1.8 2 0 0 2 2 2 0 TT viral ORF2 Slu7 PF11708.8 ELR15226.1 - 1.4 8.6 16.9 1.8 8.2 16.9 1.2 1 0 0 1 1 1 0 Pre-mRNA splicing Prp18-interacting factor Astro_capsid_p PF12226.8 ELR15226.1 - 3 6.9 13.9 4.3 6.4 13.9 1.1 1 0 0 1 1 1 0 Turkey astrovirus capsid protein Peptidase_S49_N PF08496.10 ELR15226.1 - 4 7.5 9.6 6 6.9 9.6 1.3 1 0 0 1 1 1 0 Peptidase family S49 N-terminal F-box-like PF12937.7 ELR15227.1 - 2.3e-10 40.2 0.1 2.3e-10 40.2 0.1 1.8 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 ELR15227.1 - 0.00014 21.6 0.1 0.00042 20.1 0.1 1.8 1 0 0 1 1 1 1 F-box domain Elongin_A PF06881.11 ELR15227.1 - 0.12 12.9 0.1 0.23 12.0 0.1 1.4 1 0 0 1 1 1 0 RNA polymerase II transcription factor SIII (Elongin) subunit A C1_2 PF03107.16 ELR15227.1 - 0.58 10.5 15.2 2.3 8.6 6.6 2.8 2 0 0 2 2 2 0 C1 domain Frataxin_Cyay PF01491.16 ELR15228.1 - 2.3e-34 117.7 0.0 2.8e-34 117.5 0.0 1.0 1 0 0 1 1 1 1 Frataxin-like domain HA PF03457.14 ELR15229.1 - 8.8e-35 118.9 45.0 1.7e-07 31.4 6.3 5.8 5 0 0 5 5 5 5 Helicase associated domain SHOCT PF09851.9 ELR15229.1 - 0.00028 20.5 7.9 5.3 6.9 0.1 5.8 5 0 0 5 5 5 3 Short C-terminal domain Phage_XkdX PF09693.10 ELR15229.1 - 0.47 10.5 6.9 7.9 6.6 0.0 4.2 6 0 0 6 6 6 0 Phage uncharacterised protein (Phage_XkdX) DUF3810 PF12725.7 ELR15230.1 - 0.078 12.3 4.4 0.078 12.3 4.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3810) S1FA PF04689.13 ELR15230.1 - 0.18 12.0 0.1 0.52 10.5 0.1 1.8 1 0 0 1 1 1 0 DNA binding protein S1FA MT-A70 PF05063.14 ELR15231.1 - 1.8e-11 44.2 0.0 5.3e-11 42.7 0.0 1.8 1 1 0 1 1 1 1 MT-A70 Viral_protease PF08715.10 ELR15231.1 - 0.021 14.2 0.1 0.03 13.7 0.1 1.1 1 0 0 1 1 1 0 Papain like viral protease MecA PF05389.12 ELR15231.1 - 1.9 8.1 5.6 2.8 7.5 5.6 1.2 1 0 0 1 1 1 0 Negative regulator of genetic competence (MecA) ANAPC_CDC26 PF10471.9 ELR15231.1 - 2.6 8.9 6.8 6.2 7.7 6.8 1.6 1 0 0 1 1 1 0 Anaphase-promoting complex APC subunit CDC26 Vps35 PF03635.17 ELR15233.1 - 1.2e-10 40.7 8.3 2.9e-05 22.8 0.2 3.0 3 0 0 3 3 3 2 Vacuolar protein sorting-associated protein 35 AAA_23 PF13476.6 ELR15233.1 - 0.057 13.9 0.5 0.12 12.8 0.5 1.5 1 0 0 1 1 1 0 AAA domain TipAS PF07739.13 ELR15233.1 - 2.7 8.6 10.8 23 5.6 0.1 4.8 5 0 0 5 5 5 0 TipAS antibiotic-recognition domain 2OG-FeII_Oxy_3 PF13640.6 ELR15234.1 - 7.1e-11 42.9 0.0 1.4e-10 41.9 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily CDC45 PF02724.14 ELR15234.1 - 0.72 8.1 4.3 0.89 7.8 4.3 1.1 1 0 0 1 1 1 0 CDC45-like protein RRN3 PF05327.11 ELR15234.1 - 1.8 7.0 3.8 2.3 6.7 3.8 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 TRAP_alpha PF03896.16 ELR15234.1 - 4.3 6.4 5.4 6.8 5.8 5.4 1.3 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit AOX PF01786.17 ELR15235.1 - 3.8e-94 314.3 0.2 5.5e-94 313.7 0.2 1.2 1 0 0 1 1 1 1 Alternative oxidase Endomucin PF07010.12 ELR15235.1 - 0.028 14.4 6.0 0.039 13.9 6.0 1.1 1 0 0 1 1 1 0 Endomucin Med3 PF11593.8 ELR15235.1 - 2.5 7.2 11.2 3.4 6.8 11.2 1.1 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal PhyH PF05721.13 ELR15236.1 - 8.3e-22 78.5 0.3 1.2e-21 78.0 0.3 1.2 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) 2OG-FeII_Oxy_3 PF13640.6 ELR15236.1 - 0.013 16.3 0.1 0.021 15.7 0.1 1.3 1 0 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily Complex1_LYR_2 PF13233.6 ELR15237.1 - 0.00022 21.9 0.0 0.00033 21.4 0.0 1.2 1 0 0 1 1 1 1 Complex1_LYR-like Pyr_excise PF03013.14 ELR15238.1 - 0.066 13.2 0.2 0.16 11.9 0.0 1.8 2 0 0 2 2 2 0 Pyrimidine dimer DNA glycosylase MRP-S26 PF14943.6 ELR15238.1 - 0.29 11.0 13.4 0.028 14.3 8.9 1.6 2 0 0 2 2 2 0 Mitochondrial ribosome subunit S26 MBR1 PF17058.5 ELR15238.1 - 0.82 9.9 8.0 4.4 7.5 0.2 2.3 2 0 0 2 2 2 0 Mitochondrial biogenesis regulation protein 1 Erg28 PF03694.13 ELR15239.1 - 1.4e-27 96.3 0.6 1.6e-27 96.1 0.6 1.0 1 0 0 1 1 1 1 Erg28 like protein MscS_TM PF12794.7 ELR15239.1 - 0.002 17.0 0.4 0.0024 16.8 0.4 1.1 1 0 0 1 1 1 1 Mechanosensitive ion channel inner membrane domain 1 MARVEL PF01284.23 ELR15239.1 - 0.12 12.4 7.5 0.93 9.5 7.6 1.9 1 1 0 1 1 1 0 Membrane-associating domain NifQ PF04891.12 ELR15240.1 - 0.055 13.8 0.0 0.068 13.5 0.0 1.2 1 0 0 1 1 1 0 NifQ WD40 PF00400.32 ELR15240.1 - 0.065 14.1 0.0 0.12 13.3 0.0 1.5 1 0 0 1 1 1 0 WD domain, G-beta repeat EF-1_beta_acid PF10587.9 ELR15240.1 - 6.2 7.4 8.1 12 6.4 8.1 1.5 1 0 0 1 1 1 0 Eukaryotic elongation factor 1 beta central acidic region DUF563 PF04577.14 ELR15241.1 - 4.7e-10 40.0 0.6 2.8e-08 34.2 0.0 2.6 2 0 0 2 2 2 2 Protein of unknown function (DUF563) HEAT_2 PF13646.6 ELR15242.1 - 0.0043 17.4 12.9 0.25 11.7 0.1 6.1 5 1 1 6 6 6 1 HEAT repeats Urb2 PF10441.9 ELR15242.1 - 0.014 15.4 0.8 0.049 13.6 0.1 2.3 2 1 0 2 2 2 0 Urb2/Npa2 family NopRA1 PF16201.5 ELR15242.1 - 0.035 13.7 0.2 4.2 6.9 0.0 2.8 2 0 0 2 2 2 0 Nucleolar pre-ribosomal-associated protein 1 Adaptin_N PF01602.20 ELR15242.1 - 0.036 12.6 0.1 0.15 10.5 0.0 2.1 2 0 0 2 2 2 0 Adaptin N terminal region FANCI_S2 PF14676.6 ELR15242.1 - 0.085 13.2 0.8 52 4.1 0.0 4.3 5 0 0 5 5 5 0 FANCI solenoid 2 Vac14_Fab1_bd PF12755.7 ELR15242.1 - 0.14 12.7 0.2 43 4.8 0.0 3.4 3 0 0 3 3 3 0 Vacuolar 14 Fab1-binding region HEAT PF02985.22 ELR15242.1 - 0.37 11.2 11.5 1.1 9.6 0.0 6.2 6 1 1 7 7 7 0 HEAT repeat DUF3408 PF11888.8 ELR15242.1 - 0.79 9.9 3.0 11 6.2 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3408) RIX1 PF08167.12 ELR15242.1 - 1.5 8.6 8.2 9.3 5.9 0.5 4.6 3 3 1 4 4 4 0 rRNA processing/ribosome biogenesis FGF-BP1 PF06473.12 ELR15243.1 - 0.029 14.2 4.7 0.056 13.3 4.7 1.4 1 0 0 1 1 1 0 FGF binding protein 1 (FGF-BP1) DUF5427 PF10310.9 ELR15243.1 - 0.033 13.2 5.0 0.058 12.4 5.0 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5427) CDC45 PF02724.14 ELR15243.1 - 0.09 11.1 7.5 0.096 11.0 7.5 1.1 1 0 0 1 1 1 0 CDC45-like protein RR_TM4-6 PF06459.12 ELR15243.1 - 0.15 11.9 8.6 0.23 11.2 8.6 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 UBZ_FAAP20 PF15750.5 ELR15243.1 - 0.17 11.9 0.1 0.38 10.7 0.1 1.6 1 0 0 1 1 1 0 Ubiquitin-binding zinc-finger Nucleo_P87 PF07267.11 ELR15243.1 - 0.43 9.4 8.7 0.63 8.8 8.7 1.3 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 Presenilin PF01080.17 ELR15243.1 - 0.44 9.3 4.9 0.56 8.9 4.9 1.1 1 0 0 1 1 1 0 Presenilin DNA_pol_phi PF04931.13 ELR15243.1 - 0.98 7.4 14.1 1.2 7.1 14.1 1.1 1 0 0 1 1 1 0 DNA polymerase phi TRAP_alpha PF03896.16 ELR15243.1 - 2 7.5 6.1 2.9 7.0 6.1 1.2 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit MCM_bind PF09739.9 ELR15243.1 - 4.4 5.6 6.1 6 5.2 6.1 1.1 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor Afi1 PF07792.12 ELR15243.1 - 4.9 7.6 6.4 10 6.6 6.4 1.5 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking PPL5 PF18168.1 ELR15243.1 - 8.8 5.5 7.5 14 4.9 7.5 1.2 1 0 0 1 1 1 0 Prim-pol family 5 Paf1 PF03985.13 ELR15243.1 - 9.6 5.1 19.0 15 4.5 19.0 1.1 1 0 0 1 1 1 0 Paf1 Pkinase PF00069.25 ELR15244.1 - 2.8e-44 151.4 0.6 1.8e-36 125.9 0.0 2.4 1 1 1 2 2 2 2 Protein kinase domain Kelch_5 PF13854.6 ELR15244.1 - 1.8e-31 107.6 0.1 4.3e-06 26.6 0.0 6.8 6 0 0 6 6 6 6 Kelch motif Pkinase_Tyr PF07714.17 ELR15244.1 - 1.1e-29 103.6 0.4 8.9e-26 90.7 0.0 2.5 1 1 1 2 2 2 2 Protein tyrosine kinase Kelch_3 PF13415.6 ELR15244.1 - 4.3e-21 74.7 27.1 1.3e-07 31.7 0.0 8.7 9 1 0 9 9 9 5 Galactose oxidase, central domain Kelch_1 PF01344.25 ELR15244.1 - 1.8e-19 69.0 2.4 0.0027 17.2 0.0 6.5 7 0 0 7 7 7 4 Kelch motif Kelch_4 PF13418.6 ELR15244.1 - 7.1e-19 67.6 0.2 2.6e-05 24.1 0.0 6.4 6 0 0 6 6 6 4 Galactose oxidase, central domain Kelch_6 PF13964.6 ELR15244.1 - 6e-18 64.4 3.0 0.0056 16.9 0.0 6.4 5 1 1 6 6 6 5 Kelch motif Kelch_2 PF07646.15 ELR15244.1 - 2.7e-14 52.5 12.6 0.00048 20.0 0.2 8.0 6 2 0 6 6 6 5 Kelch motif Pkinase_fungal PF17667.1 ELR15244.1 - 0.026 13.3 0.5 0.12 11.1 0.5 2.1 1 1 0 1 1 1 0 Fungal protein kinase VASP_tetra PF08776.11 ELR15245.1 - 7e-06 25.5 3.6 1.1e-05 24.9 3.6 1.3 1 0 0 1 1 1 1 VASP tetramerisation domain Macoilin PF09726.9 ELR15245.1 - 2.3 6.7 4.3 2.6 6.5 4.3 1.1 1 0 0 1 1 1 0 Macoilin family Transformer PF06495.11 ELR15245.1 - 6.9 6.7 8.6 11 6.1 8.6 1.2 1 0 0 1 1 1 0 Fruit fly transformer protein Bromodomain PF00439.25 ELR15246.1 - 9.9e-22 76.8 0.1 2.1e-21 75.8 0.1 1.6 1 0 0 1 1 1 1 Bromodomain PCAF_N PF06466.11 ELR15246.1 - 2.5e-14 53.5 0.0 8.2e-14 51.8 0.0 1.7 1 1 0 1 1 1 1 PCAF (P300/CBP-associated factor) N-terminal domain Acetyltransf_1 PF00583.25 ELR15246.1 - 9.2e-13 48.5 0.0 1.9e-12 47.5 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 ELR15246.1 - 1.3e-07 31.6 0.0 2.4e-07 30.7 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 ELR15246.1 - 2.4e-05 24.7 0.1 4.5e-05 23.8 0.1 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.7 ELR15246.1 - 0.11 13.2 0.0 0.25 12.0 0.0 1.7 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain FH2 PF02181.23 ELR15247.1 - 1.4e-63 215.2 4.3 1.9e-62 211.5 0.8 3.4 2 2 1 3 3 3 2 Formin Homology 2 Domain Drf_FH3 PF06367.16 ELR15247.1 - 1e-34 119.9 0.8 1e-34 119.9 0.8 2.0 2 0 0 2 2 2 1 Diaphanous FH3 Domain Drf_GBD PF06371.13 ELR15247.1 - 4.1e-18 65.6 6.1 4.1e-18 65.6 6.1 3.3 3 1 0 3 3 3 1 Diaphanous GTPase-binding Domain Acetyltransf_1 PF00583.25 ELR15248.1 - 1.3e-16 60.9 0.1 1.6e-16 60.6 0.1 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 ELR15248.1 - 9.8e-11 41.7 0.0 1.3e-10 41.3 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 ELR15248.1 - 1.4e-09 38.2 0.1 2.5e-09 37.4 0.1 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain AstA PF04958.12 ELR15248.1 - 0.023 13.3 0.0 0.044 12.3 0.0 1.5 1 1 1 2 2 2 0 Arginine N-succinyltransferase beta subunit Acetyltransf_9 PF13527.7 ELR15248.1 - 0.066 13.3 0.0 0.1 12.7 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain FAD_binding_3 PF01494.19 ELR15249.1 - 2.7e-17 63.0 0.1 2.1e-16 60.1 0.1 2.0 1 1 0 1 1 1 1 FAD binding domain DAO PF01266.24 ELR15249.1 - 4.8e-13 49.4 0.5 2.3e-07 30.8 0.0 2.7 3 0 0 3 3 3 2 FAD dependent oxidoreductase Trp_halogenase PF04820.14 ELR15249.1 - 4e-11 42.4 0.0 6.5e-05 22.0 0.0 2.4 3 0 0 3 3 3 2 Tryptophan halogenase Lycopene_cycl PF05834.12 ELR15249.1 - 1.9e-07 30.5 0.2 0.0039 16.3 0.0 2.2 2 0 0 2 2 2 2 Lycopene cyclase protein NAD_binding_8 PF13450.6 ELR15249.1 - 4.1e-07 30.1 0.0 1.2e-06 28.6 0.0 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 ELR15249.1 - 3.4e-06 26.5 0.1 8.6e-06 25.2 0.1 1.6 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 ELR15249.1 - 6.4e-06 25.8 0.1 1e-05 25.1 0.1 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase HI0933_like PF03486.14 ELR15249.1 - 9.2e-06 24.6 0.0 1.4e-05 24.1 0.0 1.2 1 0 0 1 1 1 1 HI0933-like protein Thi4 PF01946.17 ELR15249.1 - 6.9e-05 22.2 0.0 0.00013 21.3 0.0 1.4 1 0 0 1 1 1 1 Thi4 family FAD_binding_2 PF00890.24 ELR15249.1 - 7.5e-05 22.0 0.1 0.00021 20.5 0.1 1.7 1 0 0 1 1 1 1 FAD binding domain GIDA PF01134.22 ELR15249.1 - 0.00014 21.1 0.0 0.00021 20.5 0.0 1.2 1 0 0 1 1 1 1 Glucose inhibited division protein A Pyr_redox PF00070.27 ELR15249.1 - 0.00075 20.0 0.0 0.0024 18.4 0.0 1.9 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase ApbA PF02558.16 ELR15249.1 - 0.0012 18.5 0.0 0.0024 17.5 0.0 1.4 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA UDPG_MGDP_dh_N PF03721.14 ELR15249.1 - 0.0022 17.6 0.0 0.0033 17.0 0.0 1.2 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Pyr_redox_3 PF13738.6 ELR15249.1 - 0.008 15.5 0.0 0.014 14.7 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase 3HCDH_N PF02737.18 ELR15249.1 - 0.011 15.6 0.0 0.021 14.7 0.0 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_binding_9 PF13454.6 ELR15249.1 - 0.024 14.6 0.1 0.37 10.8 0.0 2.4 2 0 0 2 2 2 0 FAD-NAD(P)-binding NAD_binding_7 PF13241.6 ELR15249.1 - 0.077 13.4 0.0 0.14 12.6 0.0 1.5 1 0 0 1 1 1 0 Putative NAD(P)-binding SE PF08491.10 ELR15249.1 - 0.22 10.6 0.0 0.42 9.6 0.0 1.4 1 0 0 1 1 1 0 Squalene epoxidase K_oxygenase PF13434.6 ELR15249.1 - 0.23 10.6 0.0 6.2 5.9 0.0 2.1 2 0 0 2 2 2 0 L-lysine 6-monooxygenase (NADPH-requiring) Strumpellin PF10266.9 ELR15250.1 - 0 1444.6 25.9 0 1437.9 25.9 2.0 1 1 0 1 1 1 1 Hereditary spastic paraplegia protein strumpellin KN_motif PF12075.8 ELR15250.1 - 0.13 12.1 0.0 0.42 10.5 0.0 1.8 1 0 0 1 1 1 0 KN motif DUF2894 PF11445.8 ELR15250.1 - 0.13 12.7 0.5 0.88 10.0 0.0 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF2894) Rrn6 PF10214.9 ELR15250.1 - 0.14 10.6 0.6 0.25 9.8 0.6 1.3 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor SPX PF03105.19 ELR15250.1 - 0.41 10.5 3.4 0.1 12.5 0.2 1.5 2 0 0 2 2 2 0 SPX domain zf-PARP PF00645.18 ELR15251.1 - 5.7e-10 39.9 0.0 1.5e-09 38.5 0.0 1.8 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region F-box-like PF12937.7 ELR15251.1 - 4.9e-09 36.0 0.6 1e-08 35.0 0.0 1.9 2 0 0 2 2 2 1 F-box-like SAP PF02037.27 ELR15251.1 - 1.7e-07 30.8 4.4 3.2e-05 23.6 0.2 3.8 3 0 0 3 3 3 2 SAP domain F-box PF00646.33 ELR15251.1 - 1.8e-07 30.9 0.0 5.6e-07 29.3 0.0 1.8 1 0 0 1 1 1 1 F-box domain DUF966 PF06136.13 ELR15251.1 - 0.031 14.0 4.3 0.051 13.3 4.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF966) TLP-20 PF06088.11 ELR15251.1 - 0.4 10.5 2.9 0.83 9.5 2.9 1.4 1 0 0 1 1 1 0 Nucleopolyhedrovirus telokin-like protein-20 (TLP20) RNA_pol_Rpc4 PF05132.14 ELR15251.1 - 0.46 10.9 3.5 0.59 10.6 1.1 2.1 2 0 0 2 2 2 0 RNA polymerase III RPC4 MRP-S33 PF08293.11 ELR15252.1 - 6.5e-07 29.5 0.3 6.5e-07 29.5 0.3 2.2 2 1 0 2 2 2 1 Mitochondrial ribosomal subunit S27 JmjC PF02373.22 ELR15253.1 - 2.8e-41 140.5 0.0 9e-41 138.9 0.0 2.0 1 0 0 1 1 1 1 JmjC domain, hydroxylase ARID PF01388.21 ELR15253.1 - 1.1e-20 74.1 0.0 2.3e-20 73.0 0.0 1.6 1 0 0 1 1 1 1 ARID/BRIGHT DNA binding domain JmjN PF02375.17 ELR15253.1 - 2.8e-16 59.2 0.5 7.1e-16 57.9 0.5 1.8 1 0 0 1 1 1 1 jmjN domain zf-C5HC2 PF02928.16 ELR15253.1 - 1.1e-12 48.2 5.6 1.1e-12 48.2 5.6 2.8 2 1 0 2 2 2 1 C5HC2 zinc finger PHD PF00628.29 ELR15253.1 - 3.5e-11 42.8 3.8 3.5e-11 42.8 3.8 3.6 3 0 0 3 3 3 1 PHD-finger zf_UBZ PF18439.1 ELR15253.1 - 8.1e-07 28.5 0.5 8.1e-07 28.5 0.5 3.0 3 0 0 3 3 3 1 Ubiquitin-Binding Zinc Finger DUF3504 PF12012.8 ELR15253.1 - 0.0039 17.1 2.8 0.0065 16.4 1.1 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF3504) SR-25 PF10500.9 ELR15253.1 - 2.7 7.6 42.7 0.33 10.5 11.6 3.6 3 1 0 3 3 3 0 Nuclear RNA-splicing-associated protein TLP-20 PF06088.11 ELR15253.1 - 6.2 6.7 9.7 3 7.7 4.0 2.5 2 0 0 2 2 2 0 Nucleopolyhedrovirus telokin-like protein-20 (TLP20) DUF1143 PF06608.11 ELR15254.1 - 0.035 14.2 0.0 0.079 13.0 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1143) DUF1772 PF08592.11 ELR15255.1 - 5.4 7.3 12.3 2e+02 2.3 12.4 2.9 1 1 0 1 1 1 0 Domain of unknown function (DUF1772) Actin PF00022.19 ELR15256.1 - 3.9e-154 513.2 0.0 1.2e-153 511.5 0.0 1.6 1 1 0 1 1 1 1 Actin 2OG-FeII_Oxy PF03171.20 ELR15257.1 - 4.9e-21 75.1 0.0 8.3e-21 74.4 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DIOX_N PF14226.6 ELR15257.1 - 1.3e-20 74.3 0.0 2.7e-20 73.3 0.0 1.5 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal Radical_SAM PF04055.21 ELR15259.1 - 2.7e-12 47.4 0.1 5.2e-07 30.2 0.1 2.3 2 0 0 2 2 2 2 Radical SAM superfamily Fer4_14 PF13394.6 ELR15259.1 - 0.0027 17.8 0.0 0.0072 16.5 0.0 1.7 1 0 0 1 1 1 1 4Fe-4S single cluster domain Sun2_CC2 PF18580.1 ELR15259.1 - 0.019 15.2 0.6 0.049 13.9 0.6 1.7 1 0 0 1 1 1 0 SUN2 coiled coil domain 2 Melibiase PF02065.18 ELR15259.1 - 0.23 10.4 0.0 0.34 9.8 0.0 1.2 1 0 0 1 1 1 0 Melibiase CG-1 PF03859.16 ELR15260.1 - 2.4e-22 78.9 0.2 1e-19 70.5 0.2 2.4 1 1 0 1 1 1 1 CG-1 domain TIG PF01833.24 ELR15260.1 - 1.2e-06 28.5 0.1 2.3e-06 27.6 0.1 1.5 1 0 0 1 1 1 1 IPT/TIG domain IQ PF00612.27 ELR15260.1 - 0.00025 20.6 11.8 0.024 14.4 0.2 3.8 4 0 0 4 4 4 3 IQ calmodulin-binding motif NOA36 PF06524.12 ELR15260.1 - 0.2 10.9 5.3 0.3 10.3 5.3 1.3 1 0 0 1 1 1 0 NOA36 protein LCAT PF02450.15 ELR15261.1 - 6.4e-37 127.6 0.1 1.4e-32 113.3 0.3 2.2 1 1 1 2 2 2 2 Lecithin:cholesterol acyltransferase Peptidase_M8 PF01457.16 ELR15262.1 - 2.8e-71 240.8 4.2 4.9e-70 236.7 1.0 3.2 1 1 1 2 2 2 2 Leishmanolysin Y_phosphatase3 PF13350.6 ELR15263.1 - 8.1e-19 68.5 0.0 1.5e-18 67.6 0.0 1.4 1 1 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase2 PF03162.13 ELR15263.1 - 2.9e-06 27.0 0.0 3.3e-06 26.8 0.0 1.2 1 0 0 1 1 1 1 Tyrosine phosphatase family DSPc PF00782.20 ELR15263.1 - 0.00019 21.2 0.0 0.00039 20.2 0.0 1.5 2 0 0 2 2 2 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 ELR15263.1 - 0.0015 18.2 0.0 0.0019 17.8 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Myotub-related PF06602.14 ELR15263.1 - 0.046 12.7 0.0 0.065 12.2 0.0 1.2 1 0 0 1 1 1 0 Myotubularin-like phosphatase domain DENN PF02141.21 ELR15264.1 - 1.5e-35 122.8 2.1 3.2e-32 112.0 0.8 2.5 2 0 0 2 2 2 2 DENN (AEX-3) domain uDENN PF03456.18 ELR15264.1 - 2e-09 38.1 0.1 1.3e-08 35.5 0.1 2.5 1 0 0 1 1 1 1 uDENN domain dDENN PF03455.19 ELR15264.1 - 9.4e-07 28.7 1.3 2.8e-06 27.2 1.3 1.9 1 0 0 1 1 1 1 dDENN domain SPA PF08616.10 ELR15264.1 - 3e-05 23.9 0.2 9.6e-05 22.3 0.1 1.9 2 0 0 2 2 2 1 Stabilization of polarity axis Avl9 PF09794.9 ELR15264.1 - 0.0084 14.8 2.3 0.015 14.0 0.9 1.9 1 1 1 2 2 2 1 Transport protein Avl9 ISG65-75 PF11727.8 ELR15265.1 - 0.03 13.6 8.0 0.039 13.2 8.0 1.1 1 0 0 1 1 1 0 Invariant surface glycoprotein Borrelia_P83 PF05262.11 ELR15265.1 - 0.042 12.4 10.1 0.055 12.0 10.1 1.0 1 0 0 1 1 1 0 Borrelia P83/100 protein EIIBC-GUT_N PF03612.14 ELR15265.1 - 0.53 10.0 2.6 0.74 9.5 2.6 1.2 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus Peptidase_S49_N PF08496.10 ELR15265.1 - 1.4 9.0 10.6 2 8.4 10.6 1.1 1 0 0 1 1 1 0 Peptidase family S49 N-terminal Presenilin PF01080.17 ELR15265.1 - 1.8 7.2 3.2 2.1 7.0 3.2 1.1 1 0 0 1 1 1 0 Presenilin DUF4337 PF14235.6 ELR15265.1 - 2.1 8.4 11.4 3 7.9 11.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) CDC45 PF02724.14 ELR15265.1 - 3.9 5.7 6.8 4.9 5.3 6.8 1.0 1 0 0 1 1 1 0 CDC45-like protein ETC_C1_NDUFA5 PF04716.14 ELR15266.1 - 1.9e-22 78.8 0.4 3.3e-22 78.1 0.4 1.4 1 0 0 1 1 1 1 ETC complex I subunit conserved region Syntaxin PF00804.25 ELR15266.1 - 0.021 14.5 0.3 0.027 14.1 0.3 1.1 1 0 0 1 1 1 0 Syntaxin DUF4145 PF13643.6 ELR15266.1 - 0.024 14.8 0.0 0.035 14.2 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4145) FATC PF02260.20 ELR15266.1 - 0.13 12.1 0.1 0.29 11.0 0.1 1.6 1 0 0 1 1 1 0 FATC domain Ribosomal_S3Ae PF01015.18 ELR15267.1 - 8.3e-90 299.8 3.9 9.8e-90 299.5 3.9 1.0 1 0 0 1 1 1 1 Ribosomal S3Ae family Abhydro_lipase PF04083.16 ELR15267.1 - 0.022 14.3 0.0 0.042 13.4 0.0 1.5 1 0 0 1 1 1 0 Partial alpha/beta-hydrolase lipase region CH PF00307.31 ELR15268.1 - 8.9e-27 93.4 0.2 6.1e-20 71.4 0.1 3.1 2 1 1 3 3 3 2 Calponin homology (CH) domain Filamin PF00630.19 ELR15268.1 - 1.7e-16 60.9 0.1 3.4e-16 59.9 0.1 1.5 1 0 0 1 1 1 1 Filamin/ABP280 repeat SH3BGR PF04908.15 ELR15268.1 - 2.5e-05 24.3 0.0 6.1e-05 23.1 0.0 1.7 1 0 0 1 1 1 1 SH3-binding, glutamic acid-rich protein CAMSAP_CH PF11971.8 ELR15268.1 - 0.051 13.4 0.1 0.13 12.1 0.1 1.6 1 1 0 1 1 1 0 CAMSAP CH domain Glutaredoxin PF00462.24 ELR15268.1 - 0.088 13.0 0.0 0.18 12.1 0.0 1.5 1 0 0 1 1 1 0 Glutaredoxin SAP PF02037.27 ELR15269.1 - 4e-07 29.6 0.8 6.8e-07 28.9 0.8 1.4 1 0 0 1 1 1 1 SAP domain ERG4_ERG24 PF01222.17 ELR15270.1 - 1.7e-58 198.5 1.6 1.3e-52 179.0 1.0 2.0 2 0 0 2 2 2 2 Ergosterol biosynthesis ERG4/ERG24 family DUF1295 PF06966.12 ELR15270.1 - 0.00017 21.2 0.1 0.00032 20.3 0.1 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) Amidohydro_1 PF01979.20 ELR15271.1 - 6.4e-68 229.6 0.7 7.6e-68 229.3 0.7 1.0 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 ELR15271.1 - 1.8e-14 54.1 4.5 1.4e-13 51.2 0.2 2.2 2 0 0 2 2 2 2 Amidohydrolase family A_deaminase PF00962.22 ELR15271.1 - 3.7e-05 23.2 0.0 8e-05 22.1 0.0 1.5 1 0 0 1 1 1 1 Adenosine/AMP deaminase Cript PF10235.9 ELR15272.1 - 4.7e-30 104.0 8.0 4.7e-30 104.0 8.0 1.6 1 1 1 2 2 2 1 Microtubule-associated protein CRIPT DUF1272 PF06906.11 ELR15272.1 - 0.0016 18.5 7.8 0.0058 16.7 2.1 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF1272) DZR PF12773.7 ELR15272.1 - 0.19 11.8 12.6 1.4 9.0 8.2 2.7 1 1 1 2 2 2 0 Double zinc ribbon zinc_ribbon_15 PF17032.5 ELR15272.1 - 0.31 11.8 11.2 0.64 10.8 7.5 2.5 2 1 0 2 2 2 0 zinc-ribbon family zf-dskA_traR PF01258.17 ELR15272.1 - 0.5 10.4 0.1 0.5 10.4 0.1 3.4 4 1 0 4 4 4 0 Prokaryotic dksA/traR C4-type zinc finger Zn_ribbon_17 PF17120.5 ELR15272.1 - 1.5 8.5 10.7 0.28 10.8 2.8 2.7 2 1 1 3 3 3 0 Zinc-ribbon, C4HC2 type DUF2039 PF10217.9 ELR15272.1 - 1.8 8.9 15.3 0.26 11.7 8.0 2.2 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2039) HMA PF00403.26 ELR15272.1 - 7.7 7.0 9.9 27 5.3 2.3 3.1 3 0 0 3 3 3 0 Heavy-metal-associated domain FGF-BP1 PF06473.12 ELR15273.1 - 0.03 14.2 0.0 0.041 13.7 0.0 1.2 1 0 0 1 1 1 0 FGF binding protein 1 (FGF-BP1) Uricase PF01014.18 ELR15274.1 - 2.5e-58 196.0 1.1 9.9e-34 116.4 0.0 2.0 2 0 0 2 2 2 2 Uricase FolB PF02152.18 ELR15274.1 - 0.15 12.6 0.2 3.6 8.2 0.0 2.3 2 0 0 2 2 2 0 Dihydroneopterin aldolase DUF1168 PF06658.12 ELR15275.1 - 5e-28 97.6 32.9 9e-28 96.8 32.9 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF1168) TAF4 PF05236.14 ELR15275.1 - 0.58 9.8 22.7 0.68 9.6 22.7 1.1 1 0 0 1 1 1 0 Transcription initiation factor TFIID component TAF4 family Asp-B-Hydro_N PF05279.11 ELR15275.1 - 1.1 9.2 16.7 1.4 9.0 16.7 1.2 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region GAGA_bind PF06217.12 ELR15275.1 - 2.8 8.1 15.2 3.5 7.8 15.2 1.3 1 0 0 1 1 1 0 GAGA binding protein-like family DUF3807 PF12720.7 ELR15275.1 - 3.2 8.0 24.8 4.5 7.5 24.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) DUF4407 PF14362.6 ELR15275.1 - 3.3 7.0 14.8 3.6 6.8 14.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) XRN_M PF17846.1 ELR15275.1 - 4.2 6.2 12.6 4.8 6.0 12.6 1.1 1 0 0 1 1 1 0 Xrn1 helical domain Vfa1 PF08432.10 ELR15275.1 - 7.9 6.8 23.5 12 6.2 23.5 1.4 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 DASH_Spc19 PF08287.11 ELR15275.1 - 9.4 6.1 23.9 14 5.6 23.8 1.3 1 1 0 1 1 1 0 Spc19 U79_P34 PF03064.16 ELR15275.1 - 9.5 5.5 18.8 12 5.2 18.8 1.3 1 0 0 1 1 1 0 HSV U79 / HCMV P34 GTP_EFTU PF00009.27 ELR15276.1 - 8.9e-68 227.7 0.0 1.2e-67 227.2 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_IV PF03764.18 ELR15276.1 - 1.2e-31 109.0 0.0 3.8e-31 107.4 0.0 1.9 2 0 0 2 2 2 1 Elongation factor G, domain IV EFG_C PF00679.24 ELR15276.1 - 2.1e-23 82.2 0.0 5.4e-23 80.8 0.0 1.7 1 0 0 1 1 1 1 Elongation factor G C-terminus EFG_II PF14492.6 ELR15276.1 - 1.7e-15 56.8 0.0 4.7e-15 55.4 0.0 1.7 1 0 0 1 1 1 1 Elongation Factor G, domain II GTP_EFTU_D2 PF03144.25 ELR15276.1 - 5.6e-13 49.1 0.0 2.9e-12 46.8 0.0 2.2 2 0 0 2 2 2 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 ELR15276.1 - 0.00022 21.3 0.0 0.00045 20.3 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase RF3_C PF16658.5 ELR15276.1 - 0.008 16.0 0.0 0.071 12.9 0.0 2.1 2 0 0 2 2 2 1 Class II release factor RF3, C-terminal domain Na_Ca_ex PF01699.24 ELR15277.1 - 2.4e-21 76.3 48.6 8.1e-15 55.1 19.4 3.7 3 1 0 3 3 3 2 Sodium/calcium exchanger protein YccF PF03733.13 ELR15277.1 - 1.2e-20 73.9 10.9 1.2e-20 73.9 10.9 5.9 6 1 0 6 6 6 2 Inner membrane component domain PBP1_TM PF14812.6 ELR15277.1 - 6.5 7.2 6.8 5.7 7.4 4.3 2.3 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Ribosomal_L1 PF00687.21 ELR15278.1 - 2.3e-45 154.8 3.5 6.6e-45 153.4 3.5 1.8 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family UCH PF00443.29 ELR15279.1 - 1.8e-64 217.7 0.0 3.4e-64 216.8 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase DUSP PF06337.12 ELR15279.1 - 1.1e-24 86.8 0.0 2.9e-24 85.5 0.0 1.8 1 0 0 1 1 1 1 DUSP domain Ubiquitin_3 PF14836.6 ELR15279.1 - 4.8e-09 36.1 0.0 1.2e-08 34.9 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin-like domain TTL PF03133.15 ELR15280.1 - 3.4e-57 193.8 0.1 5.9e-57 193.0 0.1 1.3 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family ATPgrasp_YheCD PF14398.6 ELR15280.1 - 0.0005 19.4 0.0 0.0041 16.4 0.0 2.3 2 0 0 2 2 2 1 YheC/D like ATP-grasp Dala_Dala_lig_C PF07478.13 ELR15280.1 - 0.02 14.4 0.0 0.043 13.3 0.0 1.5 1 0 0 1 1 1 0 D-ala D-ala ligase C-terminus ATPgrasp_ST PF14397.6 ELR15280.1 - 0.036 13.3 0.0 0.061 12.6 0.0 1.3 1 0 0 1 1 1 0 Sugar-transfer associated ATP-grasp ATP-grasp_3 PF02655.14 ELR15280.1 - 0.15 12.1 0.0 0.35 10.9 0.0 1.6 1 0 0 1 1 1 0 ATP-grasp domain Peptidase_M1 PF01433.20 ELR15281.1 - 4.8e-89 297.6 0.1 7.4e-89 297.0 0.1 1.3 1 0 0 1 1 1 1 Peptidase family M1 domain ERAP1_C PF11838.8 ELR15281.1 - 4.3e-71 240.0 5.2 5e-43 147.8 0.1 3.4 3 1 1 4 4 4 2 ERAP1-like C-terminal domain Peptidase_M1_N PF17900.1 ELR15281.1 - 2.5e-54 184.3 2.2 3.5e-54 183.8 1.1 1.8 2 0 0 2 2 2 1 Peptidase M1 N-terminal domain DUF2808 PF10989.8 ELR15281.1 - 0.0099 15.9 0.2 0.027 14.5 0.2 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF2808) DUF3224 PF11528.8 ELR15281.1 - 0.069 13.0 0.1 0.14 12.0 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3224) HRXXH PF13933.6 ELR15281.1 - 0.099 12.2 0.0 0.21 11.1 0.0 1.5 1 0 0 1 1 1 0 Putative peptidase family DUF1565 PF07602.11 ELR15282.1 - 0.00084 18.7 5.4 0.052 12.9 5.4 2.2 1 1 0 1 1 1 1 Protein of unknown function (DUF1565) ANAPC4_WD40 PF12894.7 ELR15283.1 - 0.1 12.9 0.0 17 5.8 0.0 2.1 1 1 1 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain DUF1454 PF07305.12 ELR15287.1 - 0.2 11.1 0.0 0.3 10.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1454) CNDH2_C PF16858.5 ELR15287.1 - 9.4 6.0 11.1 97 2.7 11.1 2.1 1 1 0 1 1 1 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term MecA PF05389.12 ELR15290.1 - 0.054 13.1 0.2 0.069 12.8 0.2 1.1 1 0 0 1 1 1 0 Negative regulator of genetic competence (MecA) UTP15_C PF09384.10 ELR15292.1 - 4.2e-38 130.3 1.5 6.7e-38 129.7 1.5 1.3 1 0 0 1 1 1 1 UTP15 C terminal WD40 PF00400.32 ELR15292.1 - 1.6e-24 85.7 12.4 3.2e-05 24.6 0.0 7.1 6 1 1 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ELR15292.1 - 9.5e-11 41.9 0.0 5.5e-05 23.4 0.0 5.1 2 2 4 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ELR15292.1 - 0.0035 16.1 0.4 3.4 6.2 0.0 3.1 2 1 1 3 3 3 2 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 ELR15292.1 - 0.052 12.5 0.0 14 4.5 0.0 3.1 2 1 2 4 4 4 0 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ELR15292.1 - 0.16 11.2 0.0 4.7 6.5 0.0 2.4 2 0 0 2 2 2 0 WD40-like domain DUF4536 PF15055.6 ELR15293.1 - 0.00033 20.8 0.5 0.00033 20.8 0.5 1.9 2 1 0 2 2 2 1 Domain of unknown function (DUF4536) Zn_clus PF00172.18 ELR15294.1 - 0.002 18.2 5.7 0.002 18.2 5.7 2.1 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain SET PF00856.28 ELR15294.1 - 0.0038 17.6 0.1 0.0038 17.6 0.1 3.1 2 1 0 2 2 2 1 SET domain SET PF00856.28 ELR15295.1 - 1e-17 65.1 10.6 2.5e-16 60.5 10.6 2.2 1 1 0 1 1 1 1 SET domain DUF4718 PF15842.5 ELR15295.1 - 0.0081 16.0 1.1 0.012 15.5 1.1 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4718) MFAP1 PF06991.11 ELR15295.1 - 0.014 15.2 15.8 0.014 15.2 15.8 1.9 2 0 0 2 2 2 0 Microfibril-associated/Pre-mRNA processing DDRGK PF09756.9 ELR15295.1 - 4.5 6.8 18.6 11 5.6 18.6 1.6 1 0 0 1 1 1 0 DDRGK domain Hid1 PF12722.7 ELR15295.1 - 7 4.6 5.4 7.6 4.5 5.4 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein DUF2963 PF11178.8 ELR15298.1 - 0.23 11.2 0.8 1.8 8.4 0.0 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF2963) LRR_8 PF13855.6 ELR15299.1 - 2.8e-16 59.0 10.5 8.3e-10 38.3 1.8 2.1 1 1 1 2 2 2 2 Leucine rich repeat LRR_4 PF12799.7 ELR15299.1 - 3.2e-11 43.3 11.7 1e-07 32.1 5.0 2.6 1 1 1 2 2 2 2 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 ELR15299.1 - 0.0041 17.5 8.5 0.23 12.2 0.4 4.2 4 1 0 4 4 4 2 Leucine Rich Repeat LRR_9 PF14580.6 ELR15299.1 - 0.051 13.1 0.1 0.072 12.6 0.1 1.3 1 0 0 1 1 1 0 Leucine-rich repeat LRR_6 PF13516.6 ELR15299.1 - 0.72 10.1 9.4 0.47 10.6 1.7 3.7 4 0 0 4 4 4 0 Leucine Rich repeat RasGEF PF00617.19 ELR15300.1 - 6.9e-59 199.0 0.1 1.6e-58 197.8 0.1 1.6 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 ELR15300.1 - 1.3e-23 83.2 3.9 2.4e-23 82.4 1.0 2.3 2 0 0 2 2 2 1 RasGEF N-terminal motif Hydrolase_4 PF12146.8 ELR15301.1 - 7e-09 35.3 0.5 1.2e-07 31.2 0.4 2.4 1 1 0 2 2 2 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 ELR15301.1 - 6.7e-08 33.4 6.0 1.2e-07 32.6 6.0 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 ELR15301.1 - 0.00028 20.6 0.1 0.0017 18.1 0.1 2.0 1 1 0 1 1 1 1 alpha/beta hydrolase fold TTSSLRR PF12468.8 ELR15301.1 - 0.0057 16.9 0.1 0.01 16.0 0.1 1.4 1 0 0 1 1 1 1 Type III secretion system leucine rich repeat protein Abhydrolase_2 PF02230.16 ELR15301.1 - 0.021 14.6 0.0 15 5.3 0.0 3.0 3 0 0 3 3 3 0 Phospholipase/Carboxylesterase PseudoU_synth_1 PF01416.20 ELR15302.1 - 3.2e-05 24.3 0.3 0.0012 19.3 0.3 2.4 1 1 0 1 1 1 1 tRNA pseudouridine synthase Ras PF00071.22 ELR15304.1 - 8.3e-48 162.0 0.9 2.8e-47 160.3 0.9 1.7 1 1 0 1 1 1 1 Ras family Roc PF08477.13 ELR15304.1 - 1.4e-16 60.8 0.1 2.9e-16 59.8 0.1 1.5 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR15304.1 - 2.3e-07 30.5 0.1 2.4e-06 27.1 0.1 2.0 1 1 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 ELR15304.1 - 0.00023 21.1 0.8 0.11 12.4 0.0 2.3 2 1 0 2 2 2 2 RsgA GTPase GTP_EFTU PF00009.27 ELR15304.1 - 0.00066 19.3 0.3 0.0022 17.6 0.1 1.9 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain FeoB_N PF02421.18 ELR15304.1 - 0.0039 16.7 0.2 0.034 13.7 0.2 2.4 1 1 0 1 1 1 1 Ferrous iron transport protein B ATP_bind_1 PF03029.17 ELR15304.1 - 0.012 15.4 0.4 0.2 11.4 0.0 2.1 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein MMR_HSR1 PF01926.23 ELR15304.1 - 0.039 14.0 0.1 0.077 13.1 0.1 1.6 1 1 0 1 1 1 0 50S ribosome-binding GTPase TPP_enzyme_M PF00205.22 ELR15304.1 - 0.082 12.6 0.0 0.13 12.0 0.0 1.3 1 0 0 1 1 1 0 Thiamine pyrophosphate enzyme, central domain Aminotran_5 PF00266.19 ELR15305.1 - 6.4e-50 170.2 0.0 1.2e-49 169.3 0.0 1.4 1 1 0 1 1 1 1 Aminotransferase class-V TPR_16 PF13432.6 ELR15306.1 - 3.5e-16 59.6 26.4 1.1e-07 32.4 0.3 6.8 5 2 1 6 6 6 4 Tetratricopeptide repeat TPR_1 PF00515.28 ELR15306.1 - 4.8e-16 57.8 18.8 0.0073 16.1 0.0 9.0 9 1 0 9 9 9 5 Tetratricopeptide repeat TPR_2 PF07719.17 ELR15306.1 - 4.2e-14 51.4 35.3 0.002 18.1 0.7 9.1 9 0 0 9 9 9 5 Tetratricopeptide repeat TPR_19 PF14559.6 ELR15306.1 - 8.5e-13 48.6 34.0 9.1e-05 22.9 0.2 7.2 5 2 3 8 8 8 5 Tetratricopeptide repeat TPR_9 PF13371.6 ELR15306.1 - 3.4e-11 43.1 30.9 0.0015 18.6 3.5 6.3 4 2 2 6 6 6 3 Tetratricopeptide repeat TPR_14 PF13428.6 ELR15306.1 - 3.2e-10 40.0 48.7 0.0076 17.0 0.1 8.6 6 3 4 10 10 9 4 Tetratricopeptide repeat TPR_12 PF13424.6 ELR15306.1 - 5.4e-10 39.4 40.5 3.4e-05 24.0 8.5 6.5 5 1 1 6 6 6 3 Tetratricopeptide repeat TPR_17 PF13431.6 ELR15306.1 - 1.1e-09 37.9 0.9 0.016 15.5 0.0 5.8 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_11 PF13414.6 ELR15306.1 - 2.1e-09 36.9 13.5 0.00076 19.1 0.1 6.1 4 2 2 6 6 6 3 TPR repeat TPR_8 PF13181.6 ELR15306.1 - 3e-09 36.4 4.1 3.4 8.1 0.0 6.9 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_6 PF13174.6 ELR15306.1 - 5.2e-06 26.8 30.4 0.015 15.9 0.3 7.2 9 0 0 9 9 6 3 Tetratricopeptide repeat TPR_4 PF07721.14 ELR15306.1 - 7.7e-06 26.1 39.6 0.0072 16.9 3.9 8.5 6 1 1 7 7 7 1 Tetratricopeptide repeat TPR_21 PF09976.9 ELR15306.1 - 0.0002 21.1 0.1 0.0002 21.1 0.1 5.4 3 2 3 6 6 6 1 Tetratricopeptide repeat-like domain ANAPC3 PF12895.7 ELR15306.1 - 0.00021 21.5 12.0 0.64 10.3 0.0 5.3 3 2 2 5 5 5 1 Anaphase-promoting complex, cyclosome, subunit 3 BTAD PF03704.17 ELR15306.1 - 0.00031 21.2 5.3 0.00031 21.2 5.3 4.4 3 1 1 4 4 4 2 Bacterial transcriptional activator domain NARP1 PF12569.8 ELR15306.1 - 0.00044 19.3 2.6 0.52 9.2 0.0 3.1 2 1 0 3 3 3 2 NMDA receptor-regulated protein 1 TPR_20 PF14561.6 ELR15306.1 - 0.0044 17.3 14.8 0.98 9.8 0.1 5.3 3 3 2 5 5 5 2 Tetratricopeptide repeat Wzy_C_2 PF11846.8 ELR15306.1 - 0.0078 16.1 3.0 3.7 7.4 3.3 2.8 1 1 1 2 2 2 1 Virulence factor membrane-bound polymerase, C-terminal PPR PF01535.20 ELR15306.1 - 0.026 14.8 0.0 6.7 7.2 0.0 3.7 3 0 0 3 3 3 0 PPR repeat FAT PF02259.23 ELR15306.1 - 0.027 13.7 0.4 1.7 7.8 0.2 3.0 2 1 1 3 3 3 0 FAT domain TPR_7 PF13176.6 ELR15306.1 - 0.2 11.8 20.8 1.6 9.0 0.1 7.5 8 0 0 8 8 8 0 Tetratricopeptide repeat RPN7 PF10602.9 ELR15306.1 - 0.31 10.7 2.1 19 4.9 0.1 3.1 3 0 0 3 3 3 0 26S proteasome subunit RPN7 TPR_10 PF13374.6 ELR15306.1 - 3.9 7.5 26.4 5.1 7.1 0.6 6.2 6 0 0 6 6 6 0 Tetratricopeptide repeat DUF2431 PF10354.9 ELR15307.1 - 6.8e-44 150.1 0.0 4.3e-43 147.5 0.0 1.9 1 1 0 1 1 1 1 Domain of unknown function (DUF2431) BSP_II PF05432.11 ELR15307.1 - 0.077 12.7 24.0 0.15 11.7 24.0 1.4 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) Apt1 PF10351.9 ELR15307.1 - 1.8 7.4 11.1 0.3 9.9 6.6 1.9 2 0 0 2 2 2 0 Golgi-body localisation protein domain zf-RING_2 PF13639.6 ELR15308.1 - 8.3e-13 48.5 5.9 1.1e-12 48.0 5.9 1.2 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.7 ELR15308.1 - 2.5e-08 34.1 8.9 1.5e-07 31.6 8.8 2.0 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_2 PF13923.6 ELR15308.1 - 5.1e-08 32.6 5.5 8.1e-08 32.0 5.5 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 ELR15308.1 - 7.1e-08 32.1 2.8 7.1e-08 32.1 2.8 1.8 2 0 0 2 2 2 1 RING-like zinc finger zf-C3HC4 PF00097.25 ELR15308.1 - 8.6e-07 28.7 5.9 1.3e-06 28.2 5.9 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ELR15308.1 - 2.9e-05 23.9 4.2 4.1e-05 23.4 4.2 1.2 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 ELR15308.1 - 3.8e-05 23.6 4.3 6.7e-05 22.8 4.3 1.4 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 ELR15308.1 - 0.00012 21.8 3.8 0.00017 21.4 3.8 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 ELR15308.1 - 0.00029 20.8 3.2 0.0012 18.8 3.2 2.1 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-HC5HC2H_2 PF13832.6 ELR15308.1 - 0.0017 18.5 1.4 0.0029 17.7 1.4 1.4 1 0 0 1 1 1 1 PHD-zinc-finger like domain Prok-RING_4 PF14447.6 ELR15308.1 - 0.0044 16.9 2.6 0.008 16.0 2.6 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 DUF1272 PF06906.11 ELR15308.1 - 0.0093 16.0 3.1 0.015 15.4 3.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1272) zf-RING-like PF08746.11 ELR15308.1 - 0.01 16.1 4.3 0.015 15.6 4.3 1.3 1 0 0 1 1 1 0 RING-like domain zf-HC5HC2H PF13771.6 ELR15308.1 - 0.011 15.9 0.9 0.011 15.9 0.9 1.5 1 1 0 1 1 1 0 PHD-like zinc-binding domain Zn_ribbon_17 PF17120.5 ELR15308.1 - 0.021 14.4 5.2 0.04 13.5 5.2 1.4 1 1 0 1 1 1 0 Zinc-ribbon, C4HC2 type RINGv PF12906.7 ELR15308.1 - 0.035 14.2 3.4 0.071 13.2 3.4 1.5 1 1 0 1 1 1 0 RING-variant domain FANCL_C PF11793.8 ELR15308.1 - 0.13 12.4 5.6 0.38 11.0 5.6 1.8 1 1 0 1 1 1 0 FANCL C-terminal domain zf-RING_6 PF14835.6 ELR15308.1 - 0.17 11.8 0.9 0.33 10.8 0.9 1.4 1 0 0 1 1 1 0 zf-RING of BARD1-type protein GET2 PF08690.10 ELR15308.1 - 0.21 11.2 0.8 0.26 10.9 0.8 1.2 1 0 0 1 1 1 0 GET complex subunit GET2 zf-C3HC4_4 PF15227.6 ELR15308.1 - 0.46 10.7 3.2 1.3 9.3 3.3 1.8 1 1 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-RING_4 PF14570.6 ELR15308.1 - 0.78 9.6 5.3 3.2 7.6 5.6 1.8 1 1 1 2 2 2 0 RING/Ubox like zinc-binding domain ketoacyl-synt PF00109.26 ELR15309.1 - 6e-62 209.5 1.5 6.5e-62 209.4 0.4 1.6 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.22 ELR15309.1 - 2.7e-36 124.2 0.7 5.4e-36 123.2 0.7 1.5 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain Thiolase_N PF00108.23 ELR15309.1 - 0.00072 19.0 0.1 0.0015 17.9 0.1 1.5 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 ELR15309.1 - 0.008 15.8 2.7 0.14 11.8 0.2 3.2 2 2 1 3 3 3 1 Thiolase, C-terminal domain LPD37 PF18853.1 ELR15309.1 - 0.17 11.4 0.1 0.33 10.4 0.1 1.4 1 0 0 1 1 1 0 Large polyvalent protein associated domain 37 Ldh_1_C PF02866.18 ELR15310.1 - 1.8e-38 132.1 0.3 3e-38 131.4 0.1 1.5 2 0 0 2 2 2 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Ldh_1_N PF00056.23 ELR15310.1 - 2.6e-26 92.4 0.1 4.6e-26 91.6 0.1 1.4 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain RBB1NT PF08169.11 ELR15310.1 - 0.1 12.8 0.0 0.21 11.8 0.0 1.5 1 0 0 1 1 1 0 RBB1NT (NUC162) domain Homeodomain PF00046.29 ELR15311.1 - 5.2e-16 58.2 0.9 5.2e-16 58.2 0.9 3.0 3 0 0 3 3 3 1 Homeodomain Homeobox_KN PF05920.11 ELR15311.1 - 0.00051 19.9 0.0 0.00051 19.9 0.0 3.1 4 1 0 4 4 4 1 Homeobox KN domain DEAD PF00270.29 ELR15312.1 - 5.4e-37 127.3 0.0 7.3e-37 126.8 0.0 1.2 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 ELR15312.1 - 0.014 15.4 0.0 0.021 14.8 0.0 1.2 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit AAA_30 PF13604.6 ELR15312.1 - 0.023 14.4 0.1 0.15 11.8 0.1 2.1 1 1 0 1 1 1 0 AAA domain SET PF00856.28 ELR15312.1 - 0.16 12.4 0.0 2.8 8.3 0.0 2.3 1 1 0 1 1 1 0 SET domain Fis1_TPR_C PF14853.6 ELR15313.1 - 2.5e-18 65.9 1.1 2.5e-18 65.9 1.1 2.3 3 1 0 3 3 3 1 Fis1 C-terminal tetratricopeptide repeat Fis1_TPR_N PF14852.6 ELR15313.1 - 8.7e-07 28.5 0.0 2e-06 27.4 0.0 1.6 1 0 0 1 1 1 1 Fis1 N-terminal tetratricopeptide repeat TPR_2 PF07719.17 ELR15313.1 - 1.1e-05 25.2 1.8 2.6e-05 24.0 1.8 1.7 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_14 PF13428.6 ELR15313.1 - 0.00084 20.0 3.4 0.00084 20.0 3.4 2.0 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_9 PF13371.6 ELR15313.1 - 0.0041 17.2 1.2 0.0078 16.3 1.2 1.4 1 0 0 1 1 1 1 Tetratricopeptide repeat ANAPC3 PF12895.7 ELR15313.1 - 0.016 15.4 0.1 0.024 14.8 0.1 1.3 1 0 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.6 ELR15313.1 - 0.016 15.8 0.6 0.016 15.8 0.6 2.1 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_1 PF00515.28 ELR15313.1 - 0.028 14.2 1.0 0.055 13.3 1.0 1.5 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_16 PF13432.6 ELR15313.1 - 0.052 14.2 3.5 0.11 13.1 3.5 1.6 1 0 0 1 1 1 0 Tetratricopeptide repeat Alkyl_sulf_dimr PF14863.6 ELR15313.1 - 0.073 13.5 0.1 0.13 12.7 0.1 1.4 1 0 0 1 1 1 0 Alkyl sulfatase dimerisation UreF PF01730.16 ELR15314.1 - 5e-26 91.8 0.5 5e-26 91.8 0.5 2.0 2 0 0 2 2 2 1 UreF Methyltransf_11 PF08241.12 ELR15315.1 - 1.9e-16 60.4 0.0 4.2e-16 59.4 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ELR15315.1 - 7.9e-15 55.3 0.0 1.9e-14 54.1 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ELR15315.1 - 2.7e-11 43.5 0.0 3.5e-11 43.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 ELR15315.1 - 1.2e-09 38.3 0.0 1.6e-09 37.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ELR15315.1 - 8.9e-08 32.8 0.0 1.7e-07 31.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain TPMT PF05724.11 ELR15315.1 - 2.9e-07 30.4 0.0 5.2e-06 26.3 0.0 2.1 1 1 0 1 1 1 1 Thiopurine S-methyltransferase (TPMT) Ubie_methyltran PF01209.18 ELR15315.1 - 5.5e-06 25.9 0.0 8.4e-06 25.3 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family N6_N4_Mtase PF01555.18 ELR15315.1 - 0.00042 20.1 0.2 0.0016 18.2 0.2 1.9 1 1 0 1 1 1 1 DNA methylase CMAS PF02353.20 ELR15315.1 - 0.00044 19.6 0.0 0.00055 19.3 0.0 1.1 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase TehB PF03848.14 ELR15315.1 - 0.0011 18.4 0.0 0.0018 17.7 0.0 1.3 1 1 0 1 1 1 1 Tellurite resistance protein TehB Methyltransf_29 PF03141.16 ELR15315.1 - 0.02 13.5 0.0 0.44 9.0 0.0 1.9 1 1 1 2 2 2 0 Putative S-adenosyl-L-methionine-dependent methyltransferase Methyltransf_8 PF05148.15 ELR15315.1 - 0.03 14.2 0.0 0.33 10.8 0.0 2.1 1 1 0 1 1 1 0 Hypothetical methyltransferase cobW PF02492.19 ELR15316.1 - 2.5e-35 121.7 0.0 3e-35 121.4 0.0 1.1 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain MeaB PF03308.16 ELR15316.1 - 1.2e-05 24.5 0.7 0.00012 21.2 0.7 2.0 1 1 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB MMR_HSR1 PF01926.23 ELR15316.1 - 0.00041 20.4 0.0 0.001 19.1 0.0 1.7 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 ELR15316.1 - 0.0034 17.0 0.0 0.22 11.1 0.0 2.5 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain AAA_18 PF13238.6 ELR15316.1 - 0.01 16.4 0.0 0.014 15.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain Pox_A32 PF04665.12 ELR15316.1 - 0.017 14.6 0.0 0.024 14.1 0.0 1.2 1 0 0 1 1 1 0 Poxvirus A32 protein CbiA PF01656.23 ELR15316.1 - 0.021 14.9 0.0 0.035 14.1 0.0 1.3 1 0 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain ResIII PF04851.15 ELR15316.1 - 0.047 13.7 0.0 0.062 13.3 0.0 1.3 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit ATPase_2 PF01637.18 ELR15316.1 - 0.063 13.2 0.0 0.096 12.6 0.0 1.5 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea Zeta_toxin PF06414.12 ELR15316.1 - 0.068 12.4 0.0 0.1 11.8 0.0 1.2 1 0 0 1 1 1 0 Zeta toxin AAA_5 PF07728.14 ELR15316.1 - 0.071 13.1 0.0 0.12 12.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) TIP49 PF06068.13 ELR15316.1 - 0.075 12.2 0.0 0.11 11.6 0.0 1.2 1 0 0 1 1 1 0 TIP49 P-loop domain AAA PF00004.29 ELR15316.1 - 0.081 13.4 0.0 0.21 12.0 0.0 1.7 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) KAP_NTPase PF07693.14 ELR15316.1 - 0.1 11.9 0.0 0.12 11.6 0.0 1.2 1 0 0 1 1 1 0 KAP family P-loop domain NACHT PF05729.12 ELR15316.1 - 0.11 12.5 0.1 0.17 11.8 0.1 1.5 1 1 0 1 1 1 0 NACHT domain ABC_tran PF00005.27 ELR15316.1 - 0.11 13.0 0.0 0.15 12.6 0.0 1.3 1 0 0 1 1 1 0 ABC transporter NTPase_1 PF03266.15 ELR15316.1 - 0.13 12.2 0.1 0.4 10.6 0.0 1.8 2 0 0 2 2 2 0 NTPase AAA_29 PF13555.6 ELR15316.1 - 0.15 11.8 0.0 0.28 11.0 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_7 PF12775.7 ELR15316.1 - 0.22 11.0 0.0 0.32 10.5 0.0 1.2 1 0 0 1 1 1 0 P-loop containing dynein motor region Amidohydro_1 PF01979.20 ELR15317.1 - 1.8e-70 238.0 5.0 2.1e-69 234.5 5.0 2.0 1 1 0 1 1 1 1 Amidohydrolase family Urease_alpha PF00449.20 ELR15317.1 - 5.7e-48 162.2 1.6 1.2e-47 161.2 1.6 1.5 1 0 0 1 1 1 1 Urease alpha-subunit, N-terminal domain Urease_gamma PF00547.18 ELR15317.1 - 4e-45 152.2 0.2 1.1e-44 150.7 0.1 1.9 2 0 0 2 2 2 1 Urease, gamma subunit Urease_beta PF00699.20 ELR15317.1 - 1.5e-36 124.4 0.0 3.8e-36 123.0 0.0 1.7 2 0 0 2 2 2 1 Urease beta subunit Amidohydro_3 PF07969.11 ELR15317.1 - 1.2e-07 31.6 2.1 0.00029 20.4 0.0 3.2 3 1 0 4 4 4 2 Amidohydrolase family F-box-like PF12937.7 ELR15318.1 - 1.3e-09 37.8 1.6 1.3e-09 37.8 1.6 2.2 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 ELR15318.1 - 1.7e-06 27.8 1.3 3.5e-06 26.7 1.3 1.6 1 0 0 1 1 1 1 F-box domain Nucleoporin_FG PF13634.6 ELR15318.1 - 0.00024 21.9 31.8 0.00024 21.9 31.8 4.4 1 1 3 4 4 4 1 Nucleoporin FG repeat region Ank_2 PF12796.7 ELR15319.1 - 2.8e-23 82.3 0.5 3.8e-11 43.4 0.0 2.8 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 ELR15319.1 - 1.5e-19 68.0 2.8 0.0005 20.3 0.0 5.4 5 0 0 5 5 5 4 Ankyrin repeat Ank_4 PF13637.6 ELR15319.1 - 2e-17 63.3 4.3 1.3e-07 32.1 0.2 4.5 3 1 1 4 4 4 2 Ankyrin repeats (many copies) Ank PF00023.30 ELR15319.1 - 2.2e-17 62.6 5.3 8.2e-05 22.9 0.1 4.7 4 0 0 4 4 4 4 Ankyrin repeat Ank_5 PF13857.6 ELR15319.1 - 1.9e-14 53.6 6.4 4e-06 27.0 0.1 4.5 2 2 2 4 4 4 4 Ankyrin repeats (many copies) DnaJ PF00226.31 ELR15319.1 - 3.7e-12 46.2 0.1 9.2e-12 44.9 0.1 1.7 1 0 0 1 1 1 1 DnaJ domain zf-MYND PF01753.18 ELR15319.1 - 7.7e-08 32.3 7.2 1.6e-07 31.3 7.2 1.6 1 0 0 1 1 1 1 MYND finger F-box-like PF12937.7 ELR15319.1 - 3e-06 27.0 0.0 6.8e-06 25.9 0.0 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ELR15319.1 - 0.1 12.5 0.0 0.26 11.2 0.0 1.7 1 0 0 1 1 1 0 F-box domain F-box-like PF12937.7 ELR15320.1 - 1.5e-09 37.6 1.7 1.5e-09 37.6 1.7 2.3 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 ELR15320.1 - 7.9e-07 28.8 0.6 1.7e-06 27.7 0.6 1.6 1 0 0 1 1 1 1 F-box domain POTRA_TamA_1 PF17243.2 ELR15320.1 - 0.14 12.3 0.1 5.3 7.2 0.0 2.3 2 0 0 2 2 2 0 POTRA domain TamA domain 1 Nucleoporin_FG PF13634.6 ELR15320.1 - 6 7.8 71.0 0.046 14.6 27.4 3.3 1 1 2 3 3 3 0 Nucleoporin FG repeat region Ank_2 PF12796.7 ELR15321.1 - 8.1e-33 112.9 10.9 2e-11 44.3 0.0 3.7 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank_3 PF13606.6 ELR15321.1 - 8e-23 78.1 3.5 0.00072 19.8 0.0 6.4 6 0 0 6 6 6 5 Ankyrin repeat Ank_4 PF13637.6 ELR15321.1 - 1.6e-19 70.0 6.6 1.8e-07 31.6 0.2 4.9 3 2 1 4 4 4 3 Ankyrin repeats (many copies) Ank PF00023.30 ELR15321.1 - 2.5e-18 65.6 7.3 0.0012 19.1 0.1 5.7 5 0 0 5 5 5 5 Ankyrin repeat Ank_5 PF13857.6 ELR15321.1 - 6.7e-17 61.3 11.0 5.8e-06 26.5 0.2 5.5 2 2 3 5 5 5 5 Ankyrin repeats (many copies) DnaJ PF00226.31 ELR15321.1 - 4.4e-12 45.9 0.1 1.3e-11 44.4 0.1 1.9 1 0 0 1 1 1 1 DnaJ domain zf-MYND PF01753.18 ELR15321.1 - 1.1e-07 31.8 7.2 2.4e-07 30.8 7.2 1.6 1 0 0 1 1 1 1 MYND finger F-box-like PF12937.7 ELR15321.1 - 2.6e-06 27.2 0.0 6.3e-06 26.0 0.0 1.7 1 0 0 1 1 1 1 F-box-like fn3 PF00041.21 ELR15321.1 - 0.0019 18.5 0.0 0.0049 17.2 0.0 1.7 1 0 0 1 1 1 1 Fibronectin type III domain DUF1992 PF09350.10 ELR15322.1 - 5.6e-09 36.0 0.3 1.8e-08 34.4 0.2 2.0 1 1 0 1 1 1 1 Domain of unknown function (DUF1992) Cytochrom_B562 PF07361.11 ELR15322.1 - 0.036 14.7 0.6 2.1 9.1 0.0 2.4 2 0 0 2 2 2 0 Cytochrome b562 HIP1_clath_bdg PF16515.5 ELR15322.1 - 0.074 13.7 2.7 4.6 7.9 0.1 2.4 2 0 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 DUF2576 PF10845.8 ELR15322.1 - 0.12 12.0 0.2 0.25 10.9 0.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2576) DUF2096 PF09869.9 ELR15322.1 - 0.13 12.3 1.9 0.65 10.1 0.9 2.3 2 1 1 3 3 3 0 Uncharacterized protein conserved in archaea (DUF2096) Ribosomal_L39 PF00832.20 ELR15322.1 - 0.97 9.1 4.7 0.43 10.3 0.2 2.6 2 1 0 2 2 2 0 Ribosomal L39 protein Rogdi_lz PF10259.9 ELR15324.1 - 1.2e-10 41.4 0.0 2.9e-09 36.8 0.0 2.6 2 1 0 2 2 2 1 Rogdi leucine zipper containing protein GHMP_kinases_C PF08544.13 ELR15324.1 - 0.18 12.2 0.4 1.5 9.3 0.2 2.6 2 0 0 2 2 2 0 GHMP kinases C terminal LRR_4 PF12799.7 ELR15325.1 - 5.5e-14 52.1 13.2 0.1 13.0 0.0 9.0 6 1 3 10 10 10 6 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 ELR15325.1 - 2.4e-12 45.9 30.1 0.22 11.6 0.0 11.3 12 0 0 12 12 12 6 Leucine Rich repeat LRR_1 PF00560.33 ELR15325.1 - 6.2e-09 35.2 17.0 4.3 8.3 0.0 10.4 12 0 0 12 12 12 4 Leucine Rich Repeat LRR_8 PF13855.6 ELR15325.1 - 0.04 13.7 11.6 6 6.7 0.0 6.1 6 3 1 7 7 7 0 Leucine rich repeat Mito_carr PF00153.27 ELR15326.1 - 1.2e-51 172.5 6.4 2e-21 75.7 0.0 4.1 3 1 1 4 4 4 4 Mitochondrial carrier protein LIM PF00412.22 ELR15327.1 - 5.2e-12 45.8 4.8 9.7e-12 44.9 4.8 1.5 1 0 0 1 1 1 1 LIM domain Pro_isomerase PF00160.21 ELR15328.1 - 4.7e-50 170.0 0.1 5.2e-50 169.8 0.1 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Thioredoxin_3 PF13192.6 ELR15328.1 - 0.16 12.0 0.0 0.3 11.2 0.0 1.5 1 0 0 1 1 1 0 Thioredoxin domain DUF4131 PF13567.6 ELR15329.1 - 2.2 7.9 5.5 3.3 7.3 5.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) Prp18 PF02840.15 ELR15330.1 - 1e-11 45.1 3.7 1.5e-11 44.6 0.0 2.9 3 0 0 3 3 3 1 Prp18 domain TetR_C_31 PF17940.1 ELR15330.1 - 0.0062 16.7 0.1 0.019 15.2 0.0 1.9 1 1 0 1 1 1 1 Tetracyclin repressor-like, C-terminal domain PDDEXK_2 PF12784.7 ELR15330.1 - 0.031 13.8 5.3 0.049 13.2 4.8 1.6 1 1 0 1 1 1 0 PD-(D/E)XK nuclease family transposase Choline_transpo PF04515.12 ELR15331.1 - 0.058 12.6 0.4 0.059 12.6 0.4 1.0 1 0 0 1 1 1 0 Plasma-membrane choline transporter SKG6 PF08693.10 ELR15332.1 - 0.00043 19.6 8.8 0.00043 19.6 8.8 3.2 2 0 0 2 2 2 1 Transmembrane alpha-helix domain Rax2 PF12768.7 ELR15332.1 - 0.013 15.0 1.5 0.028 13.9 0.0 2.4 3 0 0 3 3 3 0 Cortical protein marker for cell polarity DUF4448 PF14610.6 ELR15332.1 - 0.3 10.8 0.0 0.3 10.8 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF4448) TPR_1 PF00515.28 ELR15333.1 - 5.1e-61 200.2 31.7 1.2e-09 37.5 0.0 8.3 8 0 0 8 8 8 7 Tetratricopeptide repeat TPR_8 PF13181.6 ELR15333.1 - 1.6e-48 158.9 18.3 5.7e-08 32.4 0.0 8.1 8 0 0 8 8 8 6 Tetratricopeptide repeat TPR_2 PF07719.17 ELR15333.1 - 7.1e-48 156.9 17.8 1.7e-06 27.7 0.6 8.3 8 0 0 8 8 8 7 Tetratricopeptide repeat TPR_11 PF13414.6 ELR15333.1 - 6.9e-46 153.7 38.9 1.8e-07 30.7 4.4 8.2 2 2 6 8 8 8 8 TPR repeat TPR_7 PF13176.6 ELR15333.1 - 6.6e-37 122.8 8.5 7e-06 25.7 0.2 7.5 7 0 0 7 7 7 6 Tetratricopeptide repeat TPR_17 PF13431.6 ELR15333.1 - 4.4e-36 120.7 25.9 4.8e-07 29.7 0.6 8.2 8 0 0 8 8 8 7 Tetratricopeptide repeat TPR_12 PF13424.6 ELR15333.1 - 1.8e-32 111.5 10.0 4.6e-09 36.4 0.1 6.0 3 2 2 5 5 5 5 Tetratricopeptide repeat TPR_10 PF13374.6 ELR15333.1 - 2.6e-30 103.4 17.3 0.0004 20.1 0.2 8.0 8 0 0 8 8 7 7 Tetratricopeptide repeat TPR_16 PF13432.6 ELR15333.1 - 6.1e-28 97.2 1.3 2.9e-07 31.0 0.5 5.6 2 2 4 6 6 6 6 Tetratricopeptide repeat TPR_19 PF14559.6 ELR15333.1 - 2.2e-23 82.6 11.2 9.3e-07 29.3 0.3 5.4 4 1 1 5 5 5 5 Tetratricopeptide repeat TPR_14 PF13428.6 ELR15333.1 - 6.9e-21 73.2 0.0 0.16 12.9 0.0 7.9 2 2 6 8 8 8 4 Tetratricopeptide repeat TPR_6 PF13174.6 ELR15333.1 - 5.6e-17 61.2 4.2 0.011 16.3 0.1 7.2 7 0 0 7 7 7 2 Tetratricopeptide repeat NARP1 PF12569.8 ELR15333.1 - 1.3e-16 60.6 2.8 1.2e-06 27.7 0.1 3.1 2 1 1 3 3 3 3 NMDA receptor-regulated protein 1 TPR_9 PF13371.6 ELR15333.1 - 1.1e-11 44.7 0.0 0.049 13.8 0.0 4.6 2 1 3 5 5 5 5 Tetratricopeptide repeat TPR_MalT PF17874.1 ELR15333.1 - 1.3e-06 28.0 1.5 1.1 8.5 0.0 3.7 2 2 1 3 3 3 3 MalT-like TPR region EST1_DNA_bind PF10373.9 ELR15333.1 - 2e-05 24.2 21.4 0.0075 15.8 0.0 5.0 3 1 2 5 5 5 3 Est1 DNA/RNA binding domain ANAPC3 PF12895.7 ELR15333.1 - 0.00035 20.7 15.4 0.055 13.7 0.1 4.5 3 1 1 4 4 4 2 Anaphase-promoting complex, cyclosome, subunit 3 Coatomer_E PF04733.14 ELR15333.1 - 0.00059 19.3 0.4 0.41 10.0 0.0 3.0 3 1 0 4 4 3 1 Coatomer epsilon subunit Sel1 PF08238.12 ELR15333.1 - 0.0013 19.3 11.0 4.7 8.0 0.3 6.1 5 1 0 5 5 5 1 Sel1 repeat Wzy_C_2 PF11846.8 ELR15333.1 - 0.0022 17.9 0.6 0.1 12.5 0.0 2.8 2 1 1 3 3 3 1 Virulence factor membrane-bound polymerase, C-terminal MIT PF04212.18 ELR15333.1 - 0.0059 16.6 28.1 2.6 8.2 3.3 7.7 6 2 2 8 8 8 1 MIT (microtubule interacting and transport) domain TPR_4 PF07721.14 ELR15333.1 - 0.006 17.1 0.0 29 5.7 0.0 4.9 5 0 0 5 5 4 0 Tetratricopeptide repeat RPN7 PF10602.9 ELR15333.1 - 0.049 13.3 13.3 5.9 6.6 0.2 5.8 2 2 2 6 6 6 0 26S proteasome subunit RPN7 DUF3794 PF12673.7 ELR15333.1 - 0.12 12.7 0.1 0.37 11.1 0.1 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF3794) FAT PF02259.23 ELR15333.1 - 0.14 11.4 2.8 3 7.0 0.2 3.2 1 1 1 3 3 3 0 FAT domain Fis1_TPR_C PF14853.6 ELR15333.1 - 0.81 9.8 13.2 13 5.9 3.5 4.4 5 0 0 5 5 4 0 Fis1 C-terminal tetratricopeptide repeat DUF2225 PF09986.9 ELR15333.1 - 2.8 7.6 13.6 9.6 5.9 2.0 3.9 1 1 2 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2225) Glyco_transf_41 PF13844.6 ELR15334.1 - 4.1e-41 140.9 0.1 1.2e-19 70.1 0.0 2.1 2 0 0 2 2 2 2 Glycosyl transferase family 41 Sporozoite_P67 PF05642.11 ELR15335.1 - 0.13 10.3 3.4 0.16 10.0 3.4 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen COMMD1_N PF17221.3 ELR15336.1 - 1.3e-34 118.6 0.3 1.6e-34 118.3 0.3 1.1 1 0 0 1 1 1 1 COMMD1 N-terminal domain COMM_domain PF07258.14 ELR15336.1 - 2.6e-06 27.4 0.0 5.7e-06 26.4 0.0 1.5 1 0 0 1 1 1 1 COMM domain DUF1896 PF08989.10 ELR15337.1 - 0.0064 16.6 0.0 5.4 7.1 0.0 2.2 2 0 0 2 2 2 2 Domain of unknown function (DUF1896) ABC_membrane PF00664.23 ELR15338.1 - 1.4e-15 57.7 10.0 2e-15 57.2 10.0 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_membrane PF00664.23 ELR15339.1 - 2.6e-31 109.3 5.3 3.6e-31 108.8 5.3 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region CoA_binding_3 PF13727.6 ELR15339.1 - 8.7 6.3 8.1 0.47 10.4 1.3 2.3 2 1 0 2 2 2 0 CoA-binding domain PhoLip_ATPase_C PF16212.5 ELR15340.1 - 4.2e-56 190.5 26.9 5.4e-56 190.1 26.9 1.1 1 0 0 1 1 1 1 Phospholipid-translocating P-type ATPase C-terminal DUF983 PF06170.12 ELR15340.1 - 0.036 14.5 1.1 0.036 14.5 1.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF983) GP11 PF08677.10 ELR15340.1 - 0.13 11.7 0.0 0.2 11.1 0.0 1.2 1 0 0 1 1 1 0 GP11 baseplate wedge protein PBP_like_2 PF12849.7 ELR15343.1 - 1.2e-20 74.4 0.2 5.6e-11 42.6 0.1 2.1 2 0 0 2 2 2 2 PBP superfamily domain Vpu PF00558.19 ELR15344.1 - 0.18 11.6 0.5 0.26 11.1 0.5 1.2 1 0 0 1 1 1 0 Vpu protein STATa_Ig PF18214.1 ELR15345.1 - 0.011 15.8 2.5 0.021 14.9 0.4 2.1 2 0 0 2 2 2 0 STATa Immunoglobulin-like domain CC2-LZ PF16516.5 ELR15345.1 - 0.016 15.6 4.9 0.016 15.6 4.9 3.4 3 1 0 3 3 3 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator YabA PF06156.13 ELR15345.1 - 0.89 10.2 14.6 0.96 10.1 7.2 3.1 1 1 1 2 2 2 0 Initiation control protein YabA Atg14 PF10186.9 ELR15345.1 - 9.4 5.2 16.2 2.6 7.0 1.7 2.2 1 1 1 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 T4_Rnl2_C PF18043.1 ELR15346.1 - 2.5e-12 46.8 0.0 2.7e-12 46.6 0.0 1.1 1 0 0 1 1 1 1 T4 RNA ligase 2 C-terminal DUF4248 PF14053.6 ELR15346.1 - 0.03 14.4 0.0 0.037 14.0 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4248) DNA_methylase PF00145.17 ELR15347.1 - 4.5e-40 138.0 0.0 1.2e-23 84.0 0.0 2.0 2 0 0 2 2 2 2 C-5 cytosine-specific DNA methylase EF-hand_1 PF00036.32 ELR15348.1 - 5.3e-19 66.3 1.5 0.0001 21.6 0.0 4.4 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 ELR15348.1 - 5.2e-17 62.1 2.4 7.1e-08 32.8 0.2 2.5 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 ELR15348.1 - 2e-15 56.3 2.1 3e-05 23.8 0.0 4.0 2 1 2 4 4 4 4 EF-hand domain pair EF-hand_6 PF13405.6 ELR15348.1 - 4.2e-15 54.3 4.1 0.0065 16.3 0.0 4.6 4 0 0 4 4 4 4 EF-hand domain Acyltransferase PF01553.21 ELR15348.1 - 2.3e-12 46.7 0.0 2.2e-11 43.5 0.0 2.3 1 1 0 1 1 1 1 Acyltransferase EF-hand_5 PF13202.6 ELR15348.1 - 2.1e-10 39.6 5.4 7e-05 22.1 0.2 3.9 4 0 0 4 4 4 2 EF hand SPARC_Ca_bdg PF10591.9 ELR15348.1 - 3.6e-05 24.0 0.0 0.46 10.8 0.0 2.4 2 0 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 ELR15348.1 - 0.00013 21.9 0.4 2.2 8.3 0.0 3.3 1 1 2 3 3 3 2 Cytoskeletal-regulatory complex EF hand Methyltransf_30 PF05430.11 ELR15348.1 - 0.16 11.9 0.0 0.34 10.8 0.0 1.5 1 0 0 1 1 1 0 S-adenosyl-L-methionine-dependent methyltransferase Sec1 PF00995.23 ELR15349.1 - 1.4e-80 272.2 0.0 1.6e-80 272.0 0.0 1.0 1 0 0 1 1 1 1 Sec1 family SLX9 PF15341.6 ELR15349.1 - 0.4 11.1 10.8 39 4.7 6.6 3.3 2 1 0 2 2 2 0 Ribosome biogenesis protein SLX9 SET PF00856.28 ELR15350.1 - 8.8e-14 52.2 0.0 2.6e-13 50.7 0.0 1.9 1 0 0 1 1 1 1 SET domain TPR_1 PF00515.28 ELR15350.1 - 3e-08 33.2 13.8 0.00077 19.2 1.4 5.2 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_12 PF13424.6 ELR15350.1 - 6.8e-08 32.7 25.5 4.6e-06 26.8 6.5 3.8 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_7 PF13176.6 ELR15350.1 - 0.00067 19.5 0.7 0.00067 19.5 0.7 4.0 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_2 PF07719.17 ELR15350.1 - 0.0024 17.8 30.1 0.0024 17.8 0.6 6.5 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_4 PF07721.14 ELR15350.1 - 0.0077 16.8 6.1 0.0077 16.8 6.1 5.4 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_8 PF13181.6 ELR15350.1 - 0.02 15.1 5.9 1.2 9.6 0.0 4.3 4 0 0 4 4 4 0 Tetratricopeptide repeat Tropomyosin_1 PF12718.7 ELR15350.1 - 0.03 14.5 0.1 0.03 14.5 0.1 2.2 3 0 0 3 3 3 0 Tropomyosin like TPR_10 PF13374.6 ELR15350.1 - 0.044 13.7 0.7 0.044 13.7 0.7 4.5 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_9 PF13371.6 ELR15350.1 - 0.51 10.5 24.8 3.6 7.8 0.5 4.8 3 2 1 4 4 4 0 Tetratricopeptide repeat Inositol_P PF00459.25 ELR15351.1 - 1.3e-42 146.2 2.4 9.2e-42 143.4 2.4 1.9 1 1 0 1 1 1 1 Inositol monophosphatase family DUF5404 PF17397.2 ELR15351.1 - 0.0098 16.1 0.1 0.016 15.4 0.1 1.3 1 0 0 1 1 1 1 Family of unknown function (DUF5404) Put_DNA-bind_N PF06971.13 ELR15351.1 - 0.17 11.9 0.3 0.78 9.8 0.0 2.1 2 0 0 2 2 2 0 Putative DNA-binding protein N-terminus Aldo_ket_red PF00248.21 ELR15352.1 - 1.3e-68 231.4 0.0 1.5e-68 231.2 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Actin PF00022.19 ELR15353.1 - 1.8e-93 313.4 0.2 5e-77 259.2 0.0 2.8 1 1 1 2 2 2 2 Actin Aldo_ket_red PF00248.21 ELR15354.1 - 2.6e-23 82.7 0.0 3.1e-23 82.4 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family PP2C PF00481.21 ELR15354.1 - 6.7e-08 32.5 0.0 8.5e-08 32.1 0.0 1.1 1 0 0 1 1 1 1 Protein phosphatase 2C Actin PF00022.19 ELR15355.1 - 2.1e-97 326.3 0.0 9.1e-97 324.2 0.0 1.7 1 1 0 1 1 1 1 Actin TOPRIM_C PF16898.5 ELR15356.1 - 0.026 14.8 1.7 0.039 14.2 0.4 2.0 2 0 0 2 2 2 0 C-terminal associated domain of TOPRIM Actin PF00022.19 ELR15357.1 - 1.4e-49 168.9 0.0 1.6e-49 168.7 0.0 1.0 1 0 0 1 1 1 1 Actin F-box-like PF12937.7 ELR15358.1 - 1.3e-05 25.0 0.4 1.6e-05 24.7 0.4 1.2 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ELR15358.1 - 0.0038 17.1 4.4 0.01 15.7 4.4 1.7 1 1 0 1 1 1 1 F-box domain RT_RNaseH PF17917.1 ELR15360.1 - 7e-32 109.8 1.4 1.3e-31 109.0 1.4 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 ELR15360.1 - 2.5e-30 104.5 0.3 4.4e-30 103.7 0.3 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 ELR15360.1 - 4.3e-13 49.3 0.2 9.9e-13 48.1 0.2 1.6 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) SspB PF04386.13 ELR15360.1 - 0.015 15.2 0.2 0.026 14.4 0.2 1.3 1 0 0 1 1 1 0 Stringent starvation protein B Mito_carr PF00153.27 ELR15361.1 - 0.0002 21.2 0.0 0.01 15.8 0.0 2.5 2 1 0 2 2 2 2 Mitochondrial carrier protein DUF1115 PF06544.12 ELR15362.1 - 3.9e-07 30.3 0.0 3.9e-07 30.3 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1115) Acyl_transf_1 PF00698.21 ELR15362.1 - 0.056 12.9 0.0 0.057 12.9 0.0 1.0 1 0 0 1 1 1 0 Acyl transferase domain NikR_C PF08753.11 ELR15362.1 - 0.13 12.4 0.0 0.16 12.2 0.0 1.1 1 0 0 1 1 1 0 NikR C terminal nickel binding domain Vault PF01505.18 ELR15365.1 - 5.7e-56 186.4 6.8 7.8e-13 48.4 0.1 5.3 5 0 0 5 5 5 4 Major Vault Protein repeat domain MVP_shoulder PF11978.8 ELR15365.1 - 1.7e-44 150.6 0.3 3.8e-44 149.5 0.3 1.6 1 0 0 1 1 1 1 Shoulder domain Vault_3 PF17795.1 ELR15365.1 - 2.5e-30 104.3 0.5 1.8e-26 91.9 0.0 4.0 4 0 0 4 4 4 2 Major Vault Protein Repeat domain Vault_4 PF17796.1 ELR15365.1 - 5e-26 90.6 0.1 1.6e-25 89.0 0.1 2.0 1 0 0 1 1 1 1 Major Vault Protein repeat domain Vault_2 PF17794.1 ELR15365.1 - 8.7e-22 77.3 0.0 1e-12 48.2 0.1 2.6 2 0 0 2 2 2 2 Major Vault Protein repeat domain DUF3601 PF12208.8 ELR15365.1 - 0.19 11.9 0.0 5.8 7.1 0.0 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF3601) DUF2543 PF10820.8 ELR15365.1 - 0.28 11.4 1.3 0.61 10.3 1.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2543) Ald_Xan_dh_C2 PF02738.18 ELR15366.1 - 8.7e-155 516.3 1.4 1.2e-154 515.8 1.4 1.2 1 0 0 1 1 1 1 Molybdopterin-binding domain of aldehyde dehydrogenase FAD_binding_5 PF00941.21 ELR15366.1 - 4.4e-41 140.4 3.0 1.4e-40 138.8 0.3 2.7 3 0 0 3 3 3 1 FAD binding domain in molybdopterin dehydrogenase Ald_Xan_dh_C PF01315.22 ELR15366.1 - 1.1e-29 103.0 0.2 3e-29 101.6 0.2 1.8 1 0 0 1 1 1 1 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain Fer2_2 PF01799.20 ELR15366.1 - 1.3e-28 98.8 0.1 2.9e-28 97.7 0.1 1.6 1 0 0 1 1 1 1 [2Fe-2S] binding domain CO_deh_flav_C PF03450.17 ELR15366.1 - 4e-08 33.4 0.1 4.4e-05 23.6 0.0 4.1 4 0 0 4 4 4 1 CO dehydrogenase flavoprotein C-terminal domain Rap_GAP PF02145.15 ELR15367.1 - 9.6e-67 224.1 0.0 1.4e-66 223.6 0.0 1.2 1 0 0 1 1 1 1 Rap/ran-GAP ENTH PF01417.20 ELR15369.1 - 2.5e-29 101.9 0.3 3.4e-29 101.4 0.3 1.2 1 0 0 1 1 1 1 ENTH domain ANTH PF07651.16 ELR15369.1 - 0.017 14.1 0.3 0.024 13.6 0.3 1.1 1 0 0 1 1 1 0 ANTH domain Epimerase PF01370.21 ELR15370.1 - 1.1e-11 44.6 0.0 1.7e-11 44.0 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.17 ELR15370.1 - 6.1e-11 41.9 0.1 3.5e-10 39.5 0.1 1.9 1 1 0 1 1 1 1 RmlD substrate binding domain 3Beta_HSD PF01073.19 ELR15370.1 - 4.1e-06 26.0 0.2 5.9e-06 25.5 0.2 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family GDP_Man_Dehyd PF16363.5 ELR15370.1 - 7.1e-06 25.6 0.0 1.2e-05 24.9 0.0 1.3 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Polysacc_synt_2 PF02719.15 ELR15370.1 - 0.0011 18.1 0.0 0.0021 17.2 0.0 1.4 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein DHHW PF14286.6 ELR15370.1 - 0.032 13.5 0.0 0.05 12.9 0.0 1.3 1 0 0 1 1 1 0 DHHW protein NAD_binding_4 PF07993.12 ELR15370.1 - 0.041 13.0 0.0 0.073 12.2 0.0 1.5 1 0 0 1 1 1 0 Male sterility protein HMG_box PF00505.19 ELR15371.1 - 2.1e-22 79.3 7.4 2.1e-22 79.3 7.4 2.4 2 0 0 2 2 2 1 HMG (high mobility group) box HMG_box_2 PF09011.10 ELR15371.1 - 4.4e-15 56.0 8.0 4.4e-15 56.0 8.0 2.7 3 0 0 3 3 3 1 HMG-box domain Fe_bilin_red PF05996.12 ELR15371.1 - 0.18 11.5 3.0 0.25 11.0 3.0 1.2 1 0 0 1 1 1 0 Ferredoxin-dependent bilin reductase zf-CpG_bind_C PF12269.8 ELR15372.1 - 7e-22 78.4 5.3 1.2e-20 74.3 5.3 2.8 1 1 0 1 1 1 1 CpG binding protein zinc finger C terminal domain PHD PF00628.29 ELR15372.1 - 1.4e-10 40.9 6.6 1.4e-10 40.9 6.6 2.6 3 0 0 3 3 3 1 PHD-finger Sporozoite_P67 PF05642.11 ELR15372.1 - 0.092 10.8 1.2 0.14 10.3 1.2 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Terminase_6 PF03237.15 ELR15372.1 - 0.099 12.3 0.0 0.16 11.6 0.0 1.3 1 0 0 1 1 1 0 Terminase-like family PHD_4 PF16866.5 ELR15372.1 - 0.28 11.3 5.5 1 9.5 3.6 2.7 2 0 0 2 2 2 0 PHD-finger Seryl_tRNA_N PF02403.22 ELR15372.1 - 1.1 9.5 5.6 0.42 10.9 0.7 2.4 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain EF-hand_1 PF00036.32 ELR15373.1 - 1.1e-27 93.5 10.6 8.2e-10 37.5 0.4 4.2 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 ELR15373.1 - 8.2e-27 93.5 4.1 7.6e-18 64.7 1.5 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 ELR15373.1 - 1.4e-25 88.8 9.9 1.9e-14 53.2 1.1 3.1 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_6 PF13405.6 ELR15373.1 - 4.1e-21 73.0 6.8 1.9e-08 33.6 0.1 4.9 3 1 2 5 5 5 4 EF-hand domain EF-hand_5 PF13202.6 ELR15373.1 - 1.4e-15 56.0 7.4 2.9e-07 29.7 0.4 4.1 4 0 0 4 4 4 3 EF hand EF-hand_9 PF14658.6 ELR15373.1 - 7.6e-10 39.0 0.3 5.2e-08 33.1 0.2 2.8 1 1 2 3 3 3 1 EF-hand domain UPF0154 PF03672.13 ELR15373.1 - 1.7e-05 24.8 0.2 0.00016 21.6 0.3 2.4 3 0 0 3 3 3 1 Uncharacterised protein family (UPF0154) EF-hand_4 PF12763.7 ELR15373.1 - 0.00021 21.2 2.8 3.3 7.7 0.2 3.0 1 1 2 3 3 3 2 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 ELR15373.1 - 0.0013 19.0 0.7 0.0071 16.7 0.2 2.1 1 1 1 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region DUF1456 PF07308.13 ELR15373.1 - 0.003 17.9 0.5 1.6 9.2 0.0 2.6 2 1 0 2 2 2 2 Protein of unknown function (DUF1456) Caleosin PF05042.13 ELR15373.1 - 0.0056 16.6 1.3 2.4 8.1 0.0 2.8 1 1 2 3 3 3 2 Caleosin related protein EF-hand_14 PF17959.1 ELR15373.1 - 0.01 16.2 0.3 0.14 12.5 0.1 2.5 1 1 1 2 2 2 0 EF-hand domain RNA_pol_Rpb4 PF03874.16 ELR15373.1 - 0.031 14.6 0.3 4 7.8 0.1 2.2 1 1 1 2 2 2 0 RNA polymerase Rpb4 Lip_prot_lig_C PF10437.9 ELR15373.1 - 0.046 13.7 0.0 7.3 6.7 0.0 2.2 2 0 0 2 2 2 0 Bacterial lipoate protein ligase C-terminus Pyr_redox_2 PF07992.14 ELR15373.1 - 0.05 12.8 0.1 0.075 12.3 0.1 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase SHOCT PF09851.9 ELR15373.1 - 0.086 12.6 0.2 6.8 6.6 0.1 3.4 3 0 0 3 3 3 0 Short C-terminal domain EF-hand_6 PF13405.6 ELR15374.1 - 9.8e-16 56.3 6.0 6.6e-05 22.5 0.3 5.0 5 0 0 5 5 5 3 EF-hand domain EF-hand_7 PF13499.6 ELR15374.1 - 1.3e-15 57.6 5.2 3.4e-11 43.4 1.5 2.8 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 ELR15374.1 - 5.1e-13 47.6 7.5 0.00035 19.9 0.8 4.4 4 0 0 4 4 4 3 EF hand EF-hand_5 PF13202.6 ELR15374.1 - 2.5e-07 29.9 6.1 0.0017 17.8 0.1 3.8 4 0 0 4 4 4 2 EF hand EF-hand_8 PF13833.6 ELR15374.1 - 0.00016 21.4 8.0 0.02 14.7 1.8 4.1 2 1 2 4 4 4 3 EF-hand domain pair EF-hand_9 PF14658.6 ELR15374.1 - 0.0016 18.8 0.1 0.0038 17.5 0.0 1.7 2 0 0 2 2 2 1 EF-hand domain SPARC_Ca_bdg PF10591.9 ELR15374.1 - 0.029 14.7 0.2 1.4 9.3 0.0 2.7 3 0 0 3 3 3 0 Secreted protein acidic and rich in cysteine Ca binding region YceG_bac PF14266.6 ELR15374.1 - 0.057 12.3 0.1 0.084 11.8 0.1 1.2 1 0 0 1 1 1 0 Putative component of 'biosynthetic module' PMBR PF09373.10 ELR15374.1 - 0.21 11.8 0.0 27 5.2 0.0 3.2 2 1 1 3 3 3 0 Pseudomurein-binding repeat AAA_33 PF13671.6 ELR15375.1 - 0.014 15.6 0.0 0.1 12.8 0.0 2.3 1 1 0 1 1 1 0 AAA domain DEAD PF00270.29 ELR15376.1 - 1.6e-33 115.9 0.0 7.5e-33 113.8 0.0 1.9 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ELR15376.1 - 5.8e-19 68.5 0.4 1.3e-18 67.4 0.4 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 ELR15376.1 - 1.6e-05 25.0 0.0 0.00021 21.3 0.0 2.2 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 ELR15376.1 - 0.0036 17.6 0.7 5.2 7.3 0.1 3.4 3 0 0 3 3 3 1 AAA domain AAA_19 PF13245.6 ELR15376.1 - 0.034 14.5 0.1 0.076 13.3 0.1 1.6 1 0 0 1 1 1 0 AAA domain DUF4217 PF13959.6 ELR15376.1 - 0.053 13.8 0.2 0.14 12.4 0.2 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4217) PhoH PF02562.16 ELR15376.1 - 0.093 12.2 0.1 0.31 10.4 0.0 1.9 2 0 0 2 2 2 0 PhoH-like protein Prenyltrans PF00432.21 ELR15377.1 - 4.6e-28 96.6 14.9 1.1e-08 34.6 0.0 6.3 6 1 0 6 6 6 5 Prenyltransferase and squalene oxidase repeat Pkinase_Tyr PF07714.17 ELR15380.1 - 8.5e-10 38.3 0.0 2e-08 33.8 0.0 2.6 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ELR15380.1 - 1.4e-08 34.5 0.0 8.3e-08 31.9 0.0 2.1 1 1 0 1 1 1 1 Protein kinase domain ATG_C PF09333.11 ELR15381.1 - 3.6e-06 27.2 0.0 3.9e-06 27.1 0.0 1.1 1 0 0 1 1 1 1 Autophagy-related protein C terminal domain DUF1084 PF06454.11 ELR15383.1 - 0.00019 20.9 5.3 0.00026 20.4 5.3 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1084) DUF1211 PF06736.11 ELR15383.1 - 0.0042 17.5 0.3 0.0082 16.6 0.3 1.5 1 1 0 1 1 1 1 Protein of unknown function (DUF1211) Oxidored_q2 PF00420.24 ELR15383.1 - 0.53 9.9 2.5 0.79 9.4 0.4 2.1 1 1 1 2 2 2 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L SET PF00856.28 ELR15384.1 - 1.1e-06 29.2 0.0 6.2e-06 26.7 0.0 2.2 2 1 0 2 2 2 1 SET domain zf-MYND PF01753.18 ELR15384.1 - 0.013 15.6 0.1 0.013 15.6 0.1 3.8 4 0 0 4 4 4 0 MYND finger KIND PF16474.5 ELR15384.1 - 0.095 12.6 1.4 0.2 11.5 1.4 1.5 1 0 0 1 1 1 0 Kinase non-catalytic C-lobe domain SAF PF08666.12 ELR15384.1 - 0.17 12.6 0.0 2.7 8.7 0.0 2.2 2 0 0 2 2 2 0 SAF domain FAM176 PF14851.6 ELR15384.1 - 0.25 11.0 6.3 1.8 8.2 2.9 2.3 2 0 0 2 2 2 0 FAM176 family LZ_Tnp_IS66 PF13007.7 ELR15384.1 - 2.1 9.2 6.2 0.3 11.9 1.5 2.0 2 0 0 2 2 2 0 Transposase C of IS166 homeodomain DUF1264 PF06884.11 ELR15385.1 - 9.7e-72 240.1 0.0 1.2e-71 239.9 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1264) DUF3592 PF12158.8 ELR15386.1 - 6.4e-05 23.0 0.0 0.0067 16.5 0.0 2.3 1 1 0 1 1 1 1 Protein of unknown function (DUF3592) DUF4632 PF15451.6 ELR15386.1 - 0.21 11.7 1.3 0.4 10.8 0.9 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4632) Adap_comp_sub PF00928.21 ELR15389.1 - 1.5e-68 231.1 0.0 2.2e-68 230.5 0.0 1.3 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 ELR15389.1 - 0.0014 18.6 0.5 0.0021 18.0 0.5 1.3 1 0 0 1 1 1 1 Clathrin adaptor complex small chain HMG-CoA_red PF00368.18 ELR15390.1 - 5.7e-152 506.0 1.4 6.5e-152 505.8 1.4 1.0 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A reductase HA PF03457.14 ELR15391.1 - 3.4e-48 161.8 42.5 2.9e-14 53.1 0.1 6.5 6 1 0 6 6 6 6 Helicase associated domain Pox_Ag35 PF03286.14 ELR15391.1 - 0.23 11.3 3.6 0.4 10.5 3.6 1.4 1 0 0 1 1 1 0 Pox virus Ag35 surface protein Glyco_hydro_47 PF01532.20 ELR15392.1 - 5.3e-134 447.6 0.0 4.1e-133 444.6 0.0 2.1 1 1 0 1 1 1 1 Glycosyl hydrolase family 47 RgpF PF05045.12 ELR15393.1 - 0.0028 16.5 0.1 0.0049 15.7 0.1 1.5 1 1 0 1 1 1 1 Rhamnan synthesis protein F DUF4291 PF14124.6 ELR15394.1 - 9.3e-45 152.7 0.0 3e-44 151.0 0.0 1.8 1 1 0 1 1 1 1 Domain of unknown function (DUF4291) WYL PF13280.6 ELR15394.1 - 0.015 15.3 0.0 0.041 13.9 0.0 1.7 2 0 0 2 2 2 0 WYL domain Flavin_Reduct PF01613.18 ELR15395.1 - 0.29 11.2 2.8 0.6 10.2 2.8 1.4 1 0 0 1 1 1 0 Flavin reductase like domain DUF1690 PF07956.11 ELR15396.1 - 4.1e-05 24.0 2.7 4.1e-05 24.0 2.7 2.2 2 0 0 2 2 2 1 Protein of Unknown function (DUF1690) FAS_N PF17828.1 ELR15396.1 - 0.16 12.0 3.4 12 5.9 0.0 2.4 2 1 0 2 2 2 0 N-terminal domain in fatty acid synthase subunit beta CHCH PF06747.13 ELR15396.1 - 0.34 11.1 3.9 0.64 10.2 3.9 1.5 1 0 0 1 1 1 0 CHCH domain Methyltransf_16 PF10294.9 ELR15397.1 - 8.1e-20 71.3 0.0 1.4e-11 44.4 0.0 2.8 2 1 0 2 2 2 2 Lysine methyltransferase MTS PF05175.14 ELR15397.1 - 0.0091 15.6 0.0 0.015 14.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain PrmA PF06325.13 ELR15397.1 - 0.033 13.6 0.0 0.064 12.6 0.0 1.4 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) LAP1C PF05609.12 ELR15397.1 - 0.16 11.0 2.0 0.25 10.4 2.0 1.2 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) TRAP_alpha PF03896.16 ELR15397.1 - 0.33 10.1 2.3 0.57 9.3 2.3 1.3 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Pox_Ag35 PF03286.14 ELR15397.1 - 2.3 7.9 7.5 4 7.2 7.5 1.3 1 0 0 1 1 1 0 Pox virus Ag35 surface protein DUF4746 PF15928.5 ELR15397.1 - 2.9 7.3 8.6 4.4 6.6 8.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) PBP_sp32 PF07222.12 ELR15397.1 - 8.4 5.8 6.9 13 5.1 6.9 1.3 1 0 0 1 1 1 0 Proacrosin binding protein sp32 Enolase_C PF00113.22 ELR15398.1 - 1.8e-154 513.3 0.1 2.3e-154 512.9 0.1 1.1 1 0 0 1 1 1 1 Enolase, C-terminal TIM barrel domain Enolase_N PF03952.16 ELR15398.1 - 4.8e-61 204.7 0.1 8.5e-61 203.9 0.1 1.4 1 0 0 1 1 1 1 Enolase, N-terminal domain MR_MLE_C PF13378.6 ELR15398.1 - 4.9e-09 36.1 0.0 7.3e-09 35.5 0.0 1.3 1 0 0 1 1 1 1 Enolase C-terminal domain-like MAAL_C PF07476.11 ELR15398.1 - 1.9e-05 24.0 0.1 3.5e-05 23.1 0.1 1.4 1 0 0 1 1 1 1 Methylaspartate ammonia-lyase C-terminus His_Phos_1 PF00300.22 ELR15399.1 - 8.2e-21 74.6 0.1 1.3e-20 74.0 0.1 1.2 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) NAD_Gly3P_dh_C PF07479.14 ELR15400.1 - 3.1e-46 157.2 0.0 6.1e-46 156.2 0.0 1.5 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus NAD_Gly3P_dh_N PF01210.23 ELR15400.1 - 3.3e-35 121.4 0.0 8.2e-33 113.6 0.0 2.8 1 1 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus DTC PF18102.1 ELR15401.1 - 4.8e-57 191.8 0.0 7.8e-57 191.1 0.0 1.3 1 0 0 1 1 1 1 Deltex C-terminal domain WWE PF02825.20 ELR15401.1 - 1.7e-15 57.4 0.0 8.7e-09 35.9 0.0 2.4 2 0 0 2 2 2 2 WWE domain zf-RING_2 PF13639.6 ELR15401.1 - 0.00026 21.3 10.3 0.0011 19.3 2.6 2.3 2 0 0 2 2 2 2 Ring finger domain zf-rbx1 PF12678.7 ELR15401.1 - 0.0016 18.7 2.3 0.0016 18.7 2.3 2.2 2 0 0 2 2 2 1 RING-H2 zinc finger domain CTU2 PF10288.9 ELR15401.1 - 0.0043 17.3 2.1 0.012 15.9 2.1 1.7 1 0 0 1 1 1 1 Cytoplasmic tRNA 2-thiolation protein 2 zf-C3HC4 PF00097.25 ELR15401.1 - 0.012 15.5 8.7 0.14 12.1 8.7 2.2 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) RNA_pol_Rpc4 PF05132.14 ELR15401.1 - 0.022 15.2 0.2 0.022 15.2 0.2 2.5 3 0 0 3 3 3 0 RNA polymerase III RPC4 DUF5523 PF17661.1 ELR15401.1 - 0.052 13.2 8.9 0.08 12.6 8.9 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5523) zf-RING_11 PF17123.5 ELR15401.1 - 0.12 12.2 0.1 0.12 12.2 0.1 3.0 3 0 0 3 3 3 0 RING-like zinc finger RR_TM4-6 PF06459.12 ELR15401.1 - 0.46 10.3 6.0 0.7 9.7 6.0 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 zf-C3HC4_2 PF13923.6 ELR15401.1 - 0.54 10.1 11.4 0.058 13.2 3.9 2.2 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING_6 PF14835.6 ELR15401.1 - 0.77 9.7 7.4 0.57 10.1 2.3 2.6 2 0 0 2 2 2 0 zf-RING of BARD1-type protein CCDC106 PF15794.5 ELR15401.1 - 3.6 7.2 8.0 0.097 12.4 1.2 1.7 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 106 SOG2 PF10428.9 ELR15401.1 - 4.2 6.4 11.5 8 5.5 11.5 1.3 1 0 0 1 1 1 0 RAM signalling pathway protein CDC45 PF02724.14 ELR15401.1 - 5.3 5.2 9.6 7.3 4.7 9.6 1.2 1 0 0 1 1 1 0 CDC45-like protein Ephrin_rec_like PF07699.13 ELR15402.1 - 5.1e-10 39.0 52.8 2.1e-05 24.2 9.8 5.8 2 1 3 6 6 6 4 Putative ephrin-receptor like Cofilin_ADF PF00241.20 ELR15403.1 - 1.7e-39 134.4 0.0 7.9e-22 77.3 0.0 2.1 2 0 0 2 2 2 2 Cofilin/tropomyosin-type actin-binding protein Tim17 PF02466.19 ELR15404.1 - 8.2e-10 39.1 12.3 1.2e-09 38.5 12.3 1.3 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family Collar PF07484.12 ELR15404.1 - 0.012 15.6 0.3 0.047 13.7 0.3 2.1 2 0 0 2 2 2 0 Phage Tail Collar Domain ThiW PF09512.10 ELR15404.1 - 1.2 9.3 7.0 0.33 11.0 2.8 2.0 1 1 1 2 2 2 0 Thiamine-precursor transporter protein (ThiW) RRM_1 PF00076.22 ELR15405.1 - 4.4e-11 42.4 0.0 9e-11 41.4 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CTD_bind PF04818.13 ELR15405.1 - 5.8e-11 43.1 0.0 1.4e-10 41.8 0.0 1.7 1 0 0 1 1 1 1 RNA polymerase II-binding domain. Nup35_RRM_2 PF14605.6 ELR15405.1 - 4.4e-06 26.6 0.0 9.9e-06 25.5 0.0 1.5 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif Armet PF10208.9 ELR15406.1 - 5.6e-05 23.1 0.0 7.4e-05 22.7 0.0 1.1 1 0 0 1 1 1 1 Degradation arginine-rich protein for mis-folding SAP PF02037.27 ELR15406.1 - 0.0027 17.4 0.0 0.0072 16.0 0.0 1.7 1 1 1 2 2 2 1 SAP domain Rho_N PF07498.12 ELR15406.1 - 0.028 14.4 0.0 0.045 13.7 0.0 1.4 1 0 0 1 1 1 0 Rho termination factor, N-terminal domain Thioredoxin_8 PF13905.6 ELR15406.1 - 0.044 14.1 0.0 0.17 12.3 0.0 1.8 2 0 0 2 2 2 0 Thioredoxin-like PH PF00169.29 ELR15407.1 - 7.4e-09 36.1 0.0 0.001 19.5 0.0 2.5 2 0 0 2 2 2 2 PH domain SBF2 PF12335.8 ELR15407.1 - 1.7e-07 31.1 0.1 3.6e-07 30.0 0.1 1.4 1 0 0 1 1 1 1 Myotubularin protein TFIIA PF03153.13 ELR15407.1 - 0.0071 16.4 11.8 0.0071 16.4 11.8 1.9 2 0 0 2 2 2 1 Transcription factor IIA, alpha/beta subunit SDA1 PF05285.12 ELR15407.1 - 0.036 13.5 8.1 0.081 12.3 8.1 1.5 1 0 0 1 1 1 0 SDA1 Nop14 PF04147.12 ELR15407.1 - 0.57 8.3 12.3 0.91 7.7 12.3 1.2 1 0 0 1 1 1 0 Nop14-like family CDC45 PF02724.14 ELR15407.1 - 0.9 7.7 6.1 1.6 7.0 6.1 1.3 1 0 0 1 1 1 0 CDC45-like protein NOA36 PF06524.12 ELR15407.1 - 4.7 6.5 16.6 8.1 5.7 16.6 1.3 1 0 0 1 1 1 0 NOA36 protein Thiolase_N PF00108.23 ELR15408.1 - 1.1e-12 47.9 0.0 3.8e-12 46.1 0.0 1.8 1 1 1 2 2 2 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 ELR15408.1 - 6.4e-10 38.7 0.1 3.3e-09 36.5 0.1 2.2 1 1 1 2 2 2 1 Thiolase, C-terminal domain ACP_syn_III PF08545.10 ELR15408.1 - 0.0033 17.2 0.1 0.012 15.5 0.1 1.9 2 0 0 2 2 2 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III Ketoacyl-synt_C PF02801.22 ELR15408.1 - 0.0075 16.3 0.0 3.4 7.7 0.0 3.4 3 0 0 3 3 3 1 Beta-ketoacyl synthase, C-terminal domain ketoacyl-synt PF00109.26 ELR15408.1 - 0.012 15.2 0.9 0.046 13.3 0.2 2.1 1 1 1 2 2 2 0 Beta-ketoacyl synthase, N-terminal domain SpoVAD PF07451.11 ELR15408.1 - 0.013 14.2 0.0 0.026 13.2 0.0 1.4 1 0 0 1 1 1 0 Stage V sporulation protein AD (SpoVAD) DSBA PF01323.20 ELR15408.1 - 0.11 12.2 0.0 0.27 11.0 0.0 1.6 1 0 0 1 1 1 0 DSBA-like thioredoxin domain Arm PF00514.23 ELR15409.1 - 2.1e-26 91.1 10.4 7.5e-07 29.0 0.2 6.8 8 0 0 8 8 8 5 Armadillo/beta-catenin-like repeat Arm_2 PF04826.13 ELR15409.1 - 1.9e-12 47.2 3.8 3.7e-07 29.9 0.7 3.8 1 1 2 3 3 3 3 Armadillo-like HEAT_EZ PF13513.6 ELR15409.1 - 1.5e-08 35.0 11.8 0.014 15.9 0.3 5.6 5 1 1 6 6 6 3 HEAT-like repeat KAP PF05804.12 ELR15409.1 - 4.8e-08 31.6 0.0 0.056 11.6 0.0 3.0 2 1 1 3 3 3 3 Kinesin-associated protein (KAP) HEAT_2 PF13646.6 ELR15409.1 - 7e-08 32.8 8.1 0.0018 18.6 1.6 4.3 1 1 3 4 4 4 3 HEAT repeats HEAT PF02985.22 ELR15409.1 - 4.3e-06 26.5 8.3 1.3 9.4 0.2 5.8 6 0 0 6 6 6 2 HEAT repeat V-ATPase_H_C PF11698.8 ELR15409.1 - 1.1e-05 25.5 0.7 0.00091 19.3 0.4 3.1 2 1 2 4 4 4 2 V-ATPase subunit H DUF3361 PF11841.8 ELR15409.1 - 3.9e-05 23.6 1.8 0.95 9.4 1.0 3.7 2 1 2 4 4 4 2 Domain of unknown function (DUF3361) Cnd1 PF12717.7 ELR15409.1 - 4.8e-05 23.5 0.4 0.00015 21.9 0.3 1.9 2 1 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1 WAPL PF07814.13 ELR15409.1 - 8.4e-05 21.5 1.3 0.022 13.6 0.1 3.0 2 1 1 3 3 3 1 Wings apart-like protein regulation of heterochromatin Adaptin_N PF01602.20 ELR15409.1 - 0.00049 18.8 2.1 0.0024 16.5 1.6 2.0 1 1 1 2 2 2 1 Adaptin N terminal region DHHA1 PF02272.19 ELR15409.1 - 0.016 15.6 0.4 0.074 13.5 0.4 2.2 1 0 0 1 1 1 0 DHHA1 domain V-ATPase_H_N PF03224.14 ELR15409.1 - 0.023 14.0 0.1 0.59 9.4 0.0 2.6 1 1 1 2 2 2 0 V-ATPase subunit H IFRD PF05004.13 ELR15409.1 - 0.039 13.1 1.4 1.3 8.1 1.4 2.5 1 1 0 1 1 1 0 Interferon-related developmental regulator (IFRD) Bap31 PF05529.12 ELR15410.1 - 1.8e-21 76.4 1.7 2.1e-21 76.2 0.0 1.8 2 0 0 2 2 2 1 Bap31/Bap29 transmembrane region DUF2570 PF10828.8 ELR15410.1 - 0.013 15.3 7.7 0.021 14.6 7.7 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2570) DUF724 PF05266.14 ELR15410.1 - 0.015 15.1 14.2 0.023 14.6 14.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF724) HALZ PF02183.18 ELR15410.1 - 0.016 15.4 10.6 0.022 15.0 2.3 2.5 2 0 0 2 2 2 0 Homeobox associated leucine zipper YabA PF06156.13 ELR15410.1 - 0.052 14.2 16.3 0.23 12.1 4.5 2.3 1 1 1 2 2 2 0 Initiation control protein YabA FapA PF03961.13 ELR15410.1 - 0.065 11.8 5.4 0.073 11.7 5.4 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A GAS PF13851.6 ELR15410.1 - 0.065 12.6 19.8 0.092 12.1 19.8 1.1 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding APG6_N PF17675.1 ELR15410.1 - 0.082 13.4 14.8 0.11 13.1 14.8 1.3 1 0 0 1 1 1 0 Apg6 coiled-coil region KIAA1430 PF13879.6 ELR15410.1 - 0.12 13.1 11.6 0.19 12.5 11.6 1.3 1 0 0 1 1 1 0 KIAA1430 homologue CorA PF01544.18 ELR15410.1 - 0.17 11.2 8.2 7.4 5.8 8.6 2.0 1 1 1 2 2 2 0 CorA-like Mg2+ transporter protein Cauli_AT PF03233.13 ELR15410.1 - 0.29 11.1 5.4 0.27 11.1 4.5 1.4 2 0 0 2 2 1 0 Aphid transmission protein DUF4446 PF14584.6 ELR15410.1 - 0.38 10.7 10.1 0.11 12.5 2.8 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF4446) CLN3 PF02487.17 ELR15410.1 - 0.67 8.9 3.4 0.94 8.4 3.4 1.2 1 0 0 1 1 1 0 CLN3 protein PRKG1_interact PF15898.5 ELR15410.1 - 0.7 10.8 14.3 6.1 7.8 6.9 2.3 1 1 1 2 2 2 0 cGMP-dependent protein kinase interacting domain PTPlike_phytase PF14566.6 ELR15410.1 - 0.75 9.9 5.3 3.3 7.8 4.8 1.9 2 0 0 2 2 2 0 Inositol hexakisphosphate DivIC PF04977.15 ELR15410.1 - 0.99 9.2 20.4 0.19 11.5 6.4 2.8 1 1 1 2 2 2 0 Septum formation initiator Spc7 PF08317.11 ELR15410.1 - 1.4 7.8 18.5 1.9 7.3 18.5 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF4337 PF14235.6 ELR15410.1 - 1.4 9.0 9.4 2.1 8.4 9.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) Exonuc_VII_L PF02601.15 ELR15410.1 - 1.6 8.2 9.3 2 7.9 9.3 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit Phage_Nu1 PF07471.12 ELR15410.1 - 1.7 8.4 8.8 6.1 6.6 6.4 2.1 1 1 1 2 2 2 0 Phage DNA packaging protein Nu1 Bap31_Bap29_C PF18035.1 ELR15410.1 - 5.6 7.1 23.2 0.65 10.1 18.2 2.1 2 1 0 2 2 2 0 Bap31/Bap29 cytoplasmic coiled-coil domain Ctr PF04145.15 ELR15410.1 - 8.3 7.0 6.2 89 3.7 6.1 2.2 1 1 0 1 1 1 0 Ctr copper transporter family TGBp3 PF02495.17 ELR15411.1 - 0.24 11.1 0.4 0.41 10.3 0.4 1.2 1 0 0 1 1 1 0 Triple gene block 3 ANAPC_CDC26 PF10471.9 ELR15411.1 - 0.72 10.7 9.0 0.63 10.9 2.4 2.2 2 0 0 2 2 2 0 Anaphase-promoting complex APC subunit CDC26 Pho88 PF10032.9 ELR15412.1 - 5.2e-09 35.6 0.1 9.8e-09 34.7 0.1 1.6 1 1 0 1 1 1 1 Phosphate transport (Pho88) TT_ORF2 PF02957.15 ELR15412.1 - 0.6 11.0 4.3 0.77 10.7 4.3 1.2 1 0 0 1 1 1 0 TT viral ORF2 SRP-alpha_N PF04086.13 ELR15412.1 - 1.4 8.8 7.5 1.6 8.6 7.5 1.0 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal adh_short PF00106.25 ELR15413.1 - 7.1e-21 74.5 0.2 4.3e-11 42.6 0.0 2.2 1 1 1 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 ELR15413.1 - 8.9e-15 54.9 0.2 3.5e-07 30.0 0.0 2.1 1 1 1 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ELR15413.1 - 0.037 13.9 0.0 0.066 13.1 0.0 1.4 1 0 0 1 1 1 0 KR domain RhoGEF PF00621.20 ELR15414.1 - 7.7e-27 94.7 0.0 2.4e-26 93.1 0.0 1.8 2 0 0 2 2 2 1 RhoGEF domain Spt20 PF12090.8 ELR15414.1 - 0.0029 17.3 4.2 0.0029 17.3 4.2 4.3 5 1 1 6 6 6 2 Spt20 family IQ_SEC7_PH PF16453.5 ELR15414.1 - 0.0078 16.2 0.0 0.039 13.9 0.0 2.1 1 1 0 1 1 1 1 PH domain SAM_2 PF07647.17 ELR15414.1 - 0.035 14.2 0.0 0.07 13.3 0.0 1.4 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) PH PF00169.29 ELR15414.1 - 0.071 13.6 1.3 0.24 12.0 0.0 2.4 2 1 0 2 2 2 0 PH domain TrbI PF03743.14 ELR15414.1 - 0.32 10.8 5.0 0.093 12.6 1.4 2.0 2 0 0 2 2 2 0 Bacterial conjugation TrbI-like protein PIF1 PF05970.14 ELR15415.1 - 1.1e-09 38.0 1.8 1.4e-09 37.6 1.7 1.3 1 1 0 1 1 1 1 PIF1-like helicase AAA_30 PF13604.6 ELR15415.1 - 3.4e-06 26.9 1.1 4.1e-06 26.7 1.1 1.2 1 0 0 1 1 1 1 AAA domain AAA_7 PF12775.7 ELR15415.1 - 0.0069 15.9 0.4 0.94 9.0 0.1 2.1 1 1 1 2 2 2 2 P-loop containing dynein motor region AAA_19 PF13245.6 ELR15415.1 - 0.019 15.3 2.4 0.038 14.3 1.8 1.9 1 1 1 2 2 2 0 AAA domain AAA_22 PF13401.6 ELR15415.1 - 0.061 13.6 0.2 0.084 13.1 0.2 1.3 1 0 0 1 1 1 0 AAA domain DUF4213 PF13938.6 ELR15415.1 - 0.076 13.3 0.2 0.12 12.6 0.2 1.3 1 0 0 1 1 1 0 Putative heavy-metal chelation UvrD-helicase PF00580.21 ELR15415.1 - 0.14 11.6 0.6 0.28 10.6 0.3 1.6 2 0 0 2 2 2 0 UvrD/REP helicase N-terminal domain Herpes_Helicase PF02689.14 ELR15415.1 - 0.19 9.6 0.9 0.21 9.5 0.9 1.1 1 0 0 1 1 1 0 Helicase Aminotran_1_2 PF00155.21 ELR15416.1 - 8.5e-78 262.1 0.0 1e-39 136.8 0.0 2.0 1 1 1 2 2 2 2 Aminotransferase class I and II Aminotran_1_2 PF00155.21 ELR15417.1 - 3.1e-14 52.9 0.0 3.4e-14 52.8 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II VRR_NUC PF08774.11 ELR15418.1 - 2.2e-24 85.6 0.0 4.2e-24 84.7 0.0 1.5 1 0 0 1 1 1 1 VRR-NUC domain TPR_2 PF07719.17 ELR15418.1 - 0.0078 16.3 3.7 14 6.1 0.4 3.8 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 ELR15418.1 - 0.65 9.9 3.3 14 5.7 0.2 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat Peptidase_M3_N PF08439.10 ELR15419.1 - 0.046 14.0 0.0 0.12 12.7 0.0 1.7 1 0 0 1 1 1 0 Oligopeptidase F Endonuclease_5 PF04493.14 ELR15421.1 - 2.2e-38 131.9 0.1 2.6e-38 131.7 0.1 1.1 1 0 0 1 1 1 1 Endonuclease V MotB_plug PF13677.6 ELR15421.1 - 0.0077 15.8 0.0 0.017 14.7 0.0 1.6 1 0 0 1 1 1 1 Membrane MotB of proton-channel complex MotA/MotB OPT PF03169.15 ELR15421.1 - 0.016 13.9 0.0 0.02 13.6 0.0 1.1 1 0 0 1 1 1 0 OPT oligopeptide transporter protein NAP PF00956.18 ELR15421.1 - 0.035 13.3 0.3 0.042 13.0 0.3 1.1 1 0 0 1 1 1 0 Nucleosome assembly protein (NAP) DUF99 PF01949.16 ELR15421.1 - 0.16 11.4 0.0 0.44 9.9 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function DUF99 AcetylCoA_hyd_C PF13336.6 ELR15422.1 - 3e-62 209.1 0.0 4.7e-62 208.5 0.0 1.3 1 0 0 1 1 1 1 Acetyl-CoA hydrolase/transferase C-terminal domain AcetylCoA_hydro PF02550.15 ELR15422.1 - 9.3e-17 61.6 0.2 2.4e-16 60.3 0.0 1.7 2 0 0 2 2 2 1 Acetyl-CoA hydrolase/transferase N-terminal domain DeoRC PF00455.22 ELR15422.1 - 0.18 11.7 0.6 1.1 9.2 0.1 2.1 2 0 0 2 2 2 0 DeoR C terminal sensor domain Nucleos_tra2_C PF07662.13 ELR15423.1 - 6.7e-82 274.3 3.9 1.5e-81 273.2 3.9 1.6 1 0 0 1 1 1 1 Na+ dependent nucleoside transporter C-terminus Nucleos_tra2_N PF01773.20 ELR15423.1 - 1.8e-23 83.0 3.6 2.1e-23 82.7 1.1 2.6 2 0 0 2 2 2 1 Na+ dependent nucleoside transporter N-terminus LicD PF04991.13 ELR15424.1 - 3e-19 70.1 1.9 1.3e-13 51.7 1.3 2.1 1 1 1 2 2 2 2 LicD family Peptidase_M22 PF00814.25 ELR15425.1 - 3.8e-61 207.2 0.5 1.3e-53 182.5 0.0 2.1 2 0 0 2 2 2 2 Glycoprotease family BAT PF15915.5 ELR15425.1 - 0.038 13.9 0.0 0.096 12.6 0.0 1.6 1 0 0 1 1 1 0 GAF and HTH_10 associated domain PHO4 PF01384.20 ELR15426.1 - 3.6e-130 433.9 14.4 5e-130 433.5 14.4 1.2 1 0 0 1 1 1 1 Phosphate transporter family DUF3185 PF11381.8 ELR15426.1 - 0.059 13.4 0.2 0.059 13.4 0.2 3.8 4 1 1 5 5 5 0 Protein of unknown function (DUF3185) Mito_carr PF00153.27 ELR15427.1 - 2.2e-54 181.4 0.0 1.9e-19 69.3 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein DUF3551 PF12071.8 ELR15427.1 - 0.97 9.5 4.3 0.48 10.5 1.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3551) Mon1 PF03164.14 ELR15428.1 - 6.8e-105 351.4 0.0 1.4e-96 324.0 0.0 2.1 1 1 1 2 2 2 2 Trafficking protein Mon1 SDA1 PF05285.12 ELR15428.1 - 0.033 13.6 0.3 0.051 13.0 0.3 1.3 1 0 0 1 1 1 0 SDA1 SPX PF03105.19 ELR15428.1 - 8.6 6.2 9.8 12 5.6 9.8 1.2 1 0 0 1 1 1 0 SPX domain Myb_DNA-binding PF00249.31 ELR15429.1 - 2.2e-09 37.3 0.9 8.2e-09 35.5 0.1 2.5 2 0 0 2 2 2 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 ELR15429.1 - 2.4e-05 24.5 0.1 7.5e-05 22.9 0.1 1.9 1 0 0 1 1 1 1 Myb-like DNA-binding domain SR-25 PF10500.9 ELR15429.1 - 0.0093 15.6 3.6 0.0093 15.6 3.6 3.2 4 0 0 4 4 4 1 Nuclear RNA-splicing-associated protein SANT_DAMP1_like PF16282.5 ELR15429.1 - 0.045 13.9 0.0 0.086 13.0 0.0 1.4 1 0 0 1 1 1 0 SANT/Myb-like domain of DAMP1 Zip PF02535.22 ELR15429.1 - 0.07 12.3 0.1 0.07 12.3 0.1 2.7 2 1 0 2 2 2 0 ZIP Zinc transporter TFIIF_alpha PF05793.12 ELR15429.1 - 0.17 10.5 55.1 0.07 11.7 35.6 2.4 2 0 0 2 2 2 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) PepSY_2 PF13670.6 ELR15429.1 - 0.95 9.5 5.4 2.6 8.1 0.0 3.5 3 0 0 3 3 3 0 Peptidase propeptide and YPEB domain RhoGAP PF00620.27 ELR15430.1 - 2.8e-05 24.0 0.0 4.6e-05 23.3 0.0 1.3 1 0 0 1 1 1 1 RhoGAP domain TFIIA PF03153.13 ELR15430.1 - 3.3 7.6 6.1 4.5 7.2 6.1 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Frizzled PF01534.17 ELR15431.1 - 6.8e-32 110.8 21.1 8.6e-32 110.5 21.1 1.1 1 0 0 1 1 1 1 Frizzled/Smoothened family membrane region 7tm_2 PF00002.24 ELR15431.1 - 3.5e-09 36.3 16.1 6.5e-09 35.4 16.1 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) Dicty_CAR PF05462.11 ELR15431.1 - 4.5e-09 35.9 10.7 4.5e-09 35.9 10.7 1.9 1 1 0 2 2 2 1 Slime mold cyclic AMP receptor Fz PF01392.22 ELR15431.1 - 9.1e-09 35.9 0.8 1.9e-08 34.9 0.8 1.5 1 0 0 1 1 1 1 Fz domain Tweety PF04906.13 ELR15432.1 - 2.4e-15 56.2 6.4 8.8e-12 44.4 3.4 2.2 1 1 1 2 2 2 2 Tweety DUF2207 PF09972.9 ELR15432.1 - 0.3 9.8 1.0 0.61 8.8 0.2 1.8 3 0 0 3 3 3 0 Predicted membrane protein (DUF2207) Synaptobrevin PF00957.21 ELR15433.1 - 8.7e-32 108.8 3.8 1.4e-31 108.2 3.8 1.3 1 0 0 1 1 1 1 Synaptobrevin Longin PF13774.6 ELR15433.1 - 8.6e-12 44.9 0.0 1.5e-11 44.2 0.0 1.4 1 0 0 1 1 1 1 Regulated-SNARE-like domain Prominin PF05478.11 ELR15433.1 - 0.0034 15.4 0.0 0.0048 14.9 0.0 1.2 1 0 0 1 1 1 1 Prominin Baculo_F PF12259.8 ELR15433.1 - 0.0069 15.0 0.2 0.0094 14.5 0.2 1.2 1 0 0 1 1 1 1 Baculovirus F protein EIID-AGA PF03613.14 ELR15433.1 - 0.026 13.7 1.6 0.036 13.2 0.0 1.9 2 0 0 2 2 2 0 PTS system mannose/fructose/sorbose family IID component Taeniidae_ag PF05596.11 ELR15433.1 - 0.028 14.4 0.1 0.056 13.4 0.1 1.5 1 0 0 1 1 1 0 Taeniidae antigen EMP24_GP25L PF01105.24 ELR15433.1 - 0.036 14.0 3.2 0.099 12.6 3.2 1.6 1 1 0 1 1 1 0 emp24/gp25L/p24 family/GOLD UPF0184 PF03670.13 ELR15433.1 - 0.04 14.3 0.2 0.075 13.4 0.2 1.5 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0184) Phospholamban PF04272.14 ELR15433.1 - 0.042 13.3 0.9 0.081 12.4 0.9 1.4 1 0 0 1 1 1 0 Phospholamban DUF2721 PF11026.8 ELR15433.1 - 0.042 13.7 0.0 0.07 13.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2721) PLU-1 PF08429.11 ELR15433.1 - 0.064 12.4 0.2 0.098 11.8 0.2 1.3 1 0 0 1 1 1 0 PLU-1-like protein Nyv1_N PF09426.10 ELR15433.1 - 0.064 13.3 0.2 0.14 12.2 0.1 1.8 1 1 0 1 1 1 0 Vacuolar R-SNARE Nyv1 N terminal DUF2682 PF10909.8 ELR15433.1 - 0.088 13.3 1.6 0.2 12.1 1.5 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF2682) Orf78 PF06024.12 ELR15433.1 - 0.091 13.1 0.1 0.18 12.1 0.1 1.6 1 0 0 1 1 1 0 Orf78 (ac78) YfhD PF14151.6 ELR15434.1 - 0.59 10.3 3.7 0.95 9.7 3.7 1.3 1 0 0 1 1 1 0 YfhD-like protein Ank_2 PF12796.7 ELR15435.1 - 2.6e-32 111.3 0.1 5.6e-14 52.5 0.1 3.7 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank PF00023.30 ELR15435.1 - 1.3e-19 69.7 2.5 2.1e-06 27.9 0.0 4.2 4 0 0 4 4 4 3 Ankyrin repeat Ank_5 PF13857.6 ELR15435.1 - 1.6e-16 60.2 2.0 1.8e-05 24.9 0.0 4.3 4 1 1 5 5 5 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 ELR15435.1 - 2.3e-15 55.1 2.2 0.00035 20.8 0.0 5.4 5 0 0 5 5 5 3 Ankyrin repeat Ank_4 PF13637.6 ELR15435.1 - 1.5e-11 44.6 0.6 0.0017 18.9 0.0 4.4 3 1 1 4 4 4 3 Ankyrin repeats (many copies) F-box-like PF12937.7 ELR15435.1 - 0.22 11.5 2.4 0.3 11.0 1.2 1.8 2 0 0 2 2 2 0 F-box-like DnaJ PF00226.31 ELR15436.1 - 1.2e-19 70.2 0.4 2.9e-19 69.0 0.4 1.7 1 0 0 1 1 1 1 DnaJ domain WW PF00397.26 ELR15436.1 - 0.082 13.0 0.0 0.22 11.6 0.0 1.7 1 0 0 1 1 1 0 WW domain Med3 PF11593.8 ELR15436.1 - 1.4 8.1 8.3 2.7 7.1 7.5 1.8 2 0 0 2 2 2 0 Mediator complex subunit 3 fungal BTB_2 PF02214.22 ELR15437.1 - 1.2e-15 57.6 0.0 2.6e-15 56.5 0.0 1.6 1 0 0 1 1 1 1 BTB/POZ domain BTB_3 PF16017.5 ELR15437.1 - 0.0011 19.1 0.0 0.0033 17.5 0.0 1.8 1 0 0 1 1 1 1 BTB/POZ domain DSPc PF00782.20 ELR15438.1 - 0.012 15.5 0.0 0.15 11.9 0.0 2.0 2 0 0 2 2 2 0 Dual specificity phosphatase, catalytic domain Ras PF00071.22 ELR15441.1 - 3.9e-54 182.6 0.0 4.5e-54 182.4 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR15441.1 - 4e-21 75.4 0.0 5.7e-21 75.0 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR15441.1 - 3e-10 39.8 0.1 3.2e-10 39.7 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 ELR15441.1 - 6.7e-06 25.8 0.1 9e-06 25.4 0.1 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 ELR15441.1 - 0.0014 18.7 0.0 0.0025 17.9 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 ELR15441.1 - 0.0014 18.5 0.5 0.79 9.6 0.0 2.1 1 1 0 2 2 2 2 RsgA GTPase PBP_like_2 PF12849.7 ELR15442.1 - 8.3e-27 94.6 1.1 4.9e-19 69.1 0.8 2.2 2 0 0 2 2 2 2 PBP superfamily domain EGF_2 PF07974.13 ELR15442.1 - 0.0058 17.0 13.3 0.013 15.8 13.3 1.6 1 0 0 1 1 1 1 EGF-like domain EGF PF00008.27 ELR15442.1 - 1.3 9.4 10.0 1.1 9.7 7.5 2.2 2 1 0 2 2 2 0 EGF-like domain LON_substr_bdg PF02190.16 ELR15443.1 - 5e-26 91.9 0.0 8.3e-26 91.1 0.0 1.3 1 0 0 1 1 1 1 ATP-dependent protease La (LON) substrate-binding domain zf-C3HC4_2 PF13923.6 ELR15443.1 - 3.1e-12 46.1 10.0 5.7e-12 45.3 10.0 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 ELR15443.1 - 1.1e-09 38.0 5.0 2e-09 37.2 5.0 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 ELR15443.1 - 9.2e-09 35.0 7.7 1.8e-08 34.1 7.7 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 ELR15443.1 - 2.3e-08 34.3 8.9 4.4e-08 33.3 8.9 1.5 1 0 0 1 1 1 1 Ring finger domain zf-RING_UBOX PF13445.6 ELR15443.1 - 4.2e-08 33.1 6.2 4.4e-08 33.0 4.9 1.7 1 1 0 1 1 1 1 RING-type zinc-finger Prok-RING_4 PF14447.6 ELR15443.1 - 1.1e-06 28.3 7.7 2.1e-06 27.5 7.7 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 ELR15443.1 - 1.3e-06 28.2 7.9 2.7e-06 27.2 7.9 1.6 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_4 PF15227.6 ELR15443.1 - 3.7e-06 27.0 9.3 7.4e-06 26.0 9.3 1.5 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING TPR_2 PF07719.17 ELR15443.1 - 0.0002 21.2 0.8 0.7 10.1 0.2 2.5 2 0 0 2 2 2 2 Tetratricopeptide repeat zf-RING_10 PF16685.5 ELR15443.1 - 0.00022 21.3 4.3 0.00042 20.4 4.3 1.4 1 0 0 1 1 1 1 zinc RING finger of MSL2 zf-rbx1 PF12678.7 ELR15443.1 - 0.0024 18.1 4.0 0.0055 17.0 4.0 1.6 1 0 0 1 1 1 1 RING-H2 zinc finger domain U-box PF04564.15 ELR15443.1 - 0.0082 16.3 0.0 0.019 15.2 0.0 1.6 1 0 0 1 1 1 1 U-box domain TPR_1 PF00515.28 ELR15443.1 - 0.01 15.6 0.2 2.6 8.0 0.0 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat zf-RING_4 PF14570.6 ELR15443.1 - 0.015 15.1 6.3 0.034 13.9 6.3 1.6 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain LNP1 PF15419.6 ELR15443.1 - 0.041 14.1 0.1 0.44 10.8 0.0 2.2 2 0 0 2 2 2 0 Leukemia NUP98 fusion partner 1 TPR_14 PF13428.6 ELR15443.1 - 0.043 14.6 0.2 0.26 12.2 0.0 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat zf-RING_6 PF14835.6 ELR15443.1 - 0.5 10.3 5.1 1.1 9.1 5.1 1.6 1 0 0 1 1 1 0 zf-RING of BARD1-type protein zf-RING_11 PF17123.5 ELR15443.1 - 0.63 9.8 3.7 1.7 8.4 3.7 1.8 1 0 0 1 1 1 0 RING-like zinc finger Forkhead_N PF08430.12 ELR15443.1 - 2.7 8.6 10.6 5.1 7.7 10.6 1.4 1 0 0 1 1 1 0 Forkhead N-terminal region GATA PF00320.27 ELR15445.1 - 3.5e-07 29.7 4.7 6.9e-07 28.8 4.7 1.5 1 0 0 1 1 1 1 GATA zinc finger NMD3 PF04981.13 ELR15445.1 - 0.015 14.8 0.4 0.024 14.1 0.4 1.2 1 0 0 1 1 1 0 NMD3 family Ank_2 PF12796.7 ELR15446.1 - 1.6e-50 169.6 1.7 1.8e-18 66.9 0.0 4.1 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank PF00023.30 ELR15446.1 - 1.6e-35 120.0 0.3 8.1e-05 22.9 0.0 7.7 8 0 0 8 8 8 7 Ankyrin repeat Ank_4 PF13637.6 ELR15446.1 - 2.6e-35 120.3 0.1 2.5e-08 34.3 0.0 5.3 2 2 4 6 6 6 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 ELR15446.1 - 2e-28 95.3 0.1 0.0036 17.7 0.0 7.1 7 0 0 7 7 7 6 Ankyrin repeat Ank_5 PF13857.6 ELR15446.1 - 2.2e-25 88.4 1.8 1.7e-06 28.2 0.0 6.1 2 2 4 6 6 6 6 Ankyrin repeats (many copies) Pro_isomerase PF00160.21 ELR15447.1 - 3.6e-50 170.3 0.2 4e-50 170.2 0.2 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD UPF0086 PF01868.16 ELR15449.1 - 3.1e-29 100.7 0.0 6.2e-29 99.8 0.0 1.5 2 0 0 2 2 2 1 Domain of unknown function UPF0086 UQ_con PF00179.26 ELR15450.1 - 4.9e-29 100.8 0.0 5.9e-29 100.5 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 ELR15450.1 - 0.015 15.6 0.2 0.022 15.1 0.2 1.3 1 1 0 1 1 1 0 RWD domain UFC1 PF08694.11 ELR15450.1 - 0.018 14.7 0.0 0.023 14.4 0.0 1.1 1 0 0 1 1 1 0 Ubiquitin-fold modifier-conjugating enzyme 1 Cullin PF00888.22 ELR15451.1 - 6.5e-26 91.1 0.0 7.7e-26 90.9 0.0 1.0 1 0 0 1 1 1 1 Cullin family DSPc PF00782.20 ELR15452.1 - 7.6e-27 93.7 0.0 1.2e-26 93.0 0.0 1.4 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain RNase_H2_suC PF08615.11 ELR15452.1 - 0.53 10.5 4.4 3.5 7.8 0.2 2.4 2 0 0 2 2 2 0 Ribonuclease H2 non-catalytic subunit (Ylr154p-like) BUD22 PF09073.10 ELR15452.1 - 0.98 8.7 23.2 1.8 7.8 23.2 1.4 1 0 0 1 1 1 0 BUD22 WD40 PF00400.32 ELR15453.1 - 5.1e-39 131.6 23.8 5.8e-08 33.3 0.6 7.8 7 0 0 7 7 7 7 WD domain, G-beta repeat F-box-like PF12937.7 ELR15453.1 - 6.2e-14 51.6 0.2 1.5e-13 50.4 0.3 1.7 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 ELR15453.1 - 3.9e-09 36.2 0.1 2.8e-07 30.2 0.1 2.5 2 0 0 2 2 2 1 F-box domain ANAPC4_WD40 PF12894.7 ELR15453.1 - 1.8e-07 31.3 5.2 0.11 12.8 0.0 4.9 1 1 4 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ELR15453.1 - 0.00071 19.0 0.9 0.15 11.4 0.3 3.3 1 1 1 2 2 2 1 WD40-like domain eIF2A PF08662.11 ELR15453.1 - 0.0023 17.9 0.6 0.025 14.5 0.2 2.6 1 1 1 2 2 2 1 Eukaryotic translation initiation factor eIF2A Frtz PF11768.8 ELR15453.1 - 0.0036 15.7 0.6 0.04 12.2 0.3 2.3 2 1 0 2 2 2 1 WD repeat-containing and planar cell polarity effector protein Fritz F-box_5 PF18511.1 ELR15453.1 - 0.0057 16.2 0.1 0.016 14.7 0.1 1.8 1 0 0 1 1 1 1 F-box Nup160 PF11715.8 ELR15453.1 - 0.0087 14.7 17.4 0.19 10.3 0.0 5.6 2 1 4 7 7 7 2 Nucleoporin Nup120/160 PALB2_WD40 PF16756.5 ELR15453.1 - 0.0087 15.0 1.7 0.57 9.0 0.1 3.1 1 1 2 3 3 3 1 Partner and localizer of BRCA2 WD40 domain PRANC PF09372.10 ELR15453.1 - 0.032 14.6 0.0 0.078 13.3 0.0 1.7 1 0 0 1 1 1 0 PRANC domain TerY_C PF15616.6 ELR15453.1 - 0.032 14.3 0.1 0.08 13.1 0.1 1.6 1 0 0 1 1 1 0 TerY-C metal binding domain DUF5046 PF16465.5 ELR15453.1 - 0.044 13.2 0.1 0.95 8.8 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF5046) SR-25 PF10500.9 ELR15453.1 - 0.085 12.5 2.4 0.13 11.9 2.4 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein PPR_3 PF13812.6 ELR15456.1 - 9.6e-59 195.3 14.8 9.3e-15 54.5 0.7 8.8 4 3 6 10 10 10 8 Pentatricopeptide repeat domain PPR_2 PF13041.6 ELR15456.1 - 1.7e-57 191.4 20.9 1.1e-12 47.9 0.2 10.7 4 2 7 11 11 11 9 PPR repeat family PPR_long PF17177.4 ELR15456.1 - 1.2e-44 152.2 11.2 2.4e-16 59.7 0.2 4.8 1 1 3 4 4 4 4 Pentacotripeptide-repeat region of PRORP PPR PF01535.20 ELR15456.1 - 1.6e-40 134.6 20.8 4e-05 23.6 0.0 12.6 13 0 0 13 13 13 8 PPR repeat PPR_1 PF12854.7 ELR15456.1 - 1.7e-33 114.0 27.3 2.8e-07 30.1 0.1 11.7 12 2 0 12 12 12 7 PPR repeat TPR_19 PF14559.6 ELR15456.1 - 4.7e-06 27.0 4.4 0.066 13.7 0.0 5.9 4 2 1 6 6 6 1 Tetratricopeptide repeat ATP13 PF12921.7 ELR15456.1 - 0.00031 20.6 0.0 0.8 9.6 0.0 4.0 3 1 1 5 5 5 1 Mitochondrial ATPase expression Phage_ABA_S PF18066.1 ELR15456.1 - 0.00047 20.8 0.6 2.5 8.8 0.0 5.0 4 1 2 7 7 7 1 Phage ABA sandwich domain Clathrin PF00637.20 ELR15456.1 - 0.0017 18.3 5.0 0.56 10.1 1.3 4.2 2 1 2 4 4 4 1 Region in Clathrin and VPS RLAN PF14401.6 ELR15456.1 - 0.012 15.3 0.5 0.38 10.4 0.0 3.3 4 0 0 4 4 4 0 RimK-like ATPgrasp N-terminal domain Mito_carr PF00153.27 ELR15457.1 - 9.9e-13 47.8 0.2 2.3e-05 24.2 0.0 4.7 4 1 1 5 5 5 3 Mitochondrial carrier protein ACBP PF00887.19 ELR15457.1 - 0.18 12.1 0.1 0.55 10.5 0.0 1.8 2 0 0 2 2 2 0 Acyl CoA binding protein Aldose_epim PF01263.20 ELR15458.1 - 6.5e-43 147.2 0.0 7.8e-43 146.9 0.0 1.1 1 0 0 1 1 1 1 Aldose 1-epimerase PTPLA PF04387.14 ELR15460.1 - 6.5e-51 172.3 9.5 9.1e-51 171.9 9.5 1.2 1 0 0 1 1 1 1 Protein tyrosine phosphatase-like protein, PTPLA Cellulase PF00150.18 ELR15461.1 - 1.1e-44 153.0 0.8 1.4e-44 152.6 0.8 1.1 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) Glyco_hydro_53 PF07745.13 ELR15461.1 - 0.046 12.7 0.0 0.07 12.1 0.0 1.3 1 0 0 1 1 1 0 Glycosyl hydrolase family 53 CATSPERG PF15064.6 ELR15461.1 - 0.11 10.2 0.0 0.17 9.7 0.0 1.1 1 0 0 1 1 1 0 Cation channel sperm-associated protein subunit gamma Pollen_allerg_1 PF01357.21 ELR15461.1 - 0.64 10.1 6.0 4.1 7.5 0.4 2.6 2 0 0 2 2 2 0 Pollen allergen ZZ PF00569.17 ELR15463.1 - 7.7e-07 28.8 4.3 1.6e-06 27.8 4.3 1.4 1 0 0 1 1 1 1 Zinc finger, ZZ type Ribosomal_L38e PF01781.18 ELR15463.1 - 0.12 12.5 0.0 0.24 11.5 0.0 1.5 1 1 0 1 1 1 0 Ribosomal L38e protein family DZR PF12773.7 ELR15463.1 - 0.4 10.7 5.3 0.98 9.5 5.3 1.6 1 0 0 1 1 1 0 Double zinc ribbon SDA1 PF05285.12 ELR15463.1 - 1.8 7.9 11.3 2.2 7.6 11.3 1.1 1 0 0 1 1 1 0 SDA1 FYVE PF01363.21 ELR15463.1 - 3.3 7.9 7.4 14 5.9 7.5 1.7 1 1 0 1 1 1 0 FYVE zinc finger ZZ PF00569.17 ELR15464.1 - 1.4e-05 24.8 8.5 2.4e-05 24.1 8.5 1.4 1 0 0 1 1 1 1 Zinc finger, ZZ type Vps51 PF08700.11 ELR15465.1 - 3.9e-05 23.7 2.2 0.0089 16.1 0.0 3.4 2 2 1 3 3 3 1 Vps51/Vps67 Sec8_exocyst PF04048.14 ELR15465.1 - 0.00068 19.5 0.8 0.0016 18.3 0.8 1.7 1 1 0 1 1 1 1 Sec8 exocyst complex component specific domain Sec5 PF15469.6 ELR15465.1 - 0.036 13.9 0.4 0.064 13.1 0.3 1.6 1 1 0 1 1 1 0 Exocyst complex component Sec5 COG5 PF10392.9 ELR15465.1 - 0.22 11.7 2.6 0.13 12.4 0.3 1.7 2 0 0 2 2 2 0 Golgi transport complex subunit 5 FAM76 PF16046.5 ELR15465.1 - 0.3 10.4 1.7 0.19 11.0 0.3 1.5 2 0 0 2 2 2 0 FAM76 protein COG2 PF06148.11 ELR15465.1 - 2 8.5 5.5 0.38 10.8 0.8 2.1 2 1 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 MTS PF05175.14 ELR15466.1 - 9.8e-09 35.0 0.0 1.6e-08 34.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_25 PF13649.6 ELR15466.1 - 2e-06 28.4 0.0 3.5e-06 27.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 ELR15466.1 - 0.0013 18.2 0.0 0.023 14.1 0.0 2.0 2 0 0 2 2 2 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_11 PF08241.12 ELR15466.1 - 0.0054 17.4 0.0 0.0086 16.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ELR15466.1 - 0.0063 17.2 0.0 0.01 16.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain rRNA_methylase PF06962.12 ELR15466.1 - 0.0099 15.9 0.0 0.016 15.2 0.0 1.3 1 0 0 1 1 1 1 Putative rRNA methylase Methyltransf_31 PF13847.6 ELR15466.1 - 0.073 12.9 0.0 0.097 12.5 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain DUF938 PF06080.12 ELR15466.1 - 0.078 12.7 0.0 0.11 12.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF938) Methyltransf_24 PF13578.6 ELR15466.1 - 0.12 13.4 0.0 0.49 11.5 0.0 1.9 1 1 1 2 2 2 0 Methyltransferase domain Methyltransf_23 PF13489.6 ELR15466.1 - 0.16 11.8 0.0 0.88 9.4 0.0 1.9 2 0 0 2 2 2 0 Methyltransferase domain PsbP PF01789.16 ELR15468.1 - 0.0022 18.1 0.1 0.004 17.3 0.1 1.4 1 0 0 1 1 1 1 PsbP GCP_C_terminal PF04130.13 ELR15469.1 - 8.9e-93 311.1 23.8 2.9e-56 191.2 10.7 2.7 2 1 0 2 2 2 2 Gamma tubulin complex component C-terminal Chlorophyllase PF07224.11 ELR15469.1 - 0.00043 19.4 0.5 0.52 9.3 0.0 2.2 2 0 0 2 2 2 2 Chlorophyllase Lectin_like PF18560.1 ELR15469.1 - 0.16 12.1 0.0 29 4.8 0.0 2.3 2 0 0 2 2 2 0 Lectin like domain NUDIX PF00293.28 ELR15470.1 - 9.5e-16 58.0 0.0 1.8e-15 57.2 0.0 1.4 1 0 0 1 1 1 1 NUDIX domain TMEM240 PF15207.6 ELR15470.1 - 0.048 13.4 0.1 0.69 9.6 0.0 2.1 2 0 0 2 2 2 0 TMEM240 family MutS_V PF00488.21 ELR15471.1 - 7.7e-77 257.6 0.1 1.2e-76 256.9 0.1 1.3 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.18 ELR15471.1 - 3.7e-34 118.6 0.3 9.9e-34 117.2 0.3 1.8 1 0 0 1 1 1 1 MutS domain III MutS_I PF01624.20 ELR15471.1 - 9.1e-25 87.1 0.0 1.7e-24 86.3 0.0 1.5 1 0 0 1 1 1 1 MutS domain I MutS_II PF05188.17 ELR15471.1 - 2.2e-13 50.7 0.0 4.2e-12 46.5 0.0 2.8 2 1 0 2 2 2 1 MutS domain II MutS_IV PF05190.18 ELR15471.1 - 1.8e-11 44.2 0.1 4.2e-11 43.0 0.1 1.7 1 0 0 1 1 1 1 MutS family domain IV AAA_23 PF13476.6 ELR15471.1 - 0.07 13.6 4.7 0.61 10.6 0.0 3.0 3 0 0 3 3 3 0 AAA domain DUF4549 PF15082.6 ELR15471.1 - 0.14 11.9 0.3 0.39 10.5 0.3 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4549) Rap_GAP PF02145.15 ELR15472.1 - 1.2e-33 116.2 0.0 2.1e-33 115.5 0.0 1.3 1 0 0 1 1 1 1 Rap/ran-GAP LRR_4 PF12799.7 ELR15472.1 - 2.5e-09 37.2 5.0 0.00021 21.6 0.9 3.1 2 0 0 2 2 2 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 ELR15472.1 - 0.00014 21.5 8.0 0.0025 17.6 5.1 2.9 2 0 0 2 2 2 1 Leucine rich repeat E3_UbLigase_EDD PF11547.8 ELR15472.1 - 0.038 13.7 0.0 16 5.3 0.0 2.6 2 0 0 2 2 2 0 E3 ubiquitin ligase EDD LRR_9 PF14580.6 ELR15472.1 - 0.048 13.2 0.7 0.18 11.3 0.1 2.1 2 0 0 2 2 2 0 Leucine-rich repeat LRR_6 PF13516.6 ELR15472.1 - 0.13 12.4 1.9 8.4 6.7 0.3 3.5 3 0 0 3 3 3 0 Leucine Rich repeat LRR_1 PF00560.33 ELR15472.1 - 6.7 7.7 8.5 62 4.7 0.4 5.2 4 0 0 4 4 4 0 Leucine Rich Repeat Waikav_capsid_1 PF12264.8 ELR15472.1 - 7.2 6.1 6.8 17 4.8 0.2 2.9 2 2 1 3 3 3 0 Waikavirus capsid protein 1 NUDE_C PF04880.13 ELR15472.1 - 9.5 6.7 24.5 0.08 13.4 4.3 2.6 2 0 0 2 2 2 0 NUDE protein, C-terminal conserved region CRAL_TRIO PF00650.20 ELR15473.1 - 2.9e-29 101.9 0.1 4.6e-29 101.2 0.1 1.3 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 ELR15473.1 - 1.3e-05 25.2 0.9 4.4e-05 23.6 0.4 2.3 2 0 0 2 2 2 1 CRAL/TRIO, N-terminal domain CRAL_TRIO_2 PF13716.6 ELR15473.1 - 3.3e-05 24.1 0.0 7.7e-05 22.9 0.0 1.6 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain PH PF00169.29 ELR15473.1 - 0.00011 22.6 0.0 0.00027 21.4 0.0 1.6 1 0 0 1 1 1 1 PH domain Bac_DNA_binding PF00216.21 ELR15473.1 - 0.038 14.2 0.1 0.12 12.6 0.1 1.8 1 0 0 1 1 1 0 Bacterial DNA-binding protein Vps36-NZF-N PF16988.5 ELR15474.1 - 0.0079 15.6 0.3 1.2 8.5 0.2 2.4 2 0 0 2 2 2 2 Vacuolar protein sorting 36 NZF-N zinc-finger domain zf-CSL PF05207.13 ELR15475.1 - 8e-24 83.1 2.2 1.3e-23 82.5 2.2 1.3 1 0 0 1 1 1 1 CSL zinc finger zf-RING_7 PF02591.15 ELR15475.1 - 0.03 14.5 0.1 0.064 13.5 0.1 1.6 1 0 0 1 1 1 0 C4-type zinc ribbon domain Zn-ribbon_8 PF09723.10 ELR15475.1 - 0.047 13.8 1.1 0.091 12.9 1.1 1.5 1 0 0 1 1 1 0 Zinc ribbon domain zinc_ribbon_4 PF13717.6 ELR15475.1 - 0.089 12.7 0.3 0.089 12.7 0.3 1.6 2 0 0 2 2 2 0 zinc-ribbon domain RhoGAP PF00620.27 ELR15476.1 - 8.7e-27 93.8 0.0 1.5e-26 93.0 0.0 1.4 1 0 0 1 1 1 1 RhoGAP domain SAM_1 PF00536.30 ELR15476.1 - 8.4e-11 42.2 0.0 4.4e-10 39.9 0.0 2.1 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 ELR15476.1 - 1.8e-07 31.2 0.0 5.7e-07 29.5 0.0 1.9 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) DEP PF00610.21 ELR15476.1 - 2.3e-07 30.8 0.0 4.4e-07 29.9 0.0 1.4 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) Peptidase_S49_N PF08496.10 ELR15476.1 - 0.0017 18.4 0.8 0.0055 16.8 0.5 1.9 2 0 0 2 2 2 1 Peptidase family S49 N-terminal UPF0242 PF06785.11 ELR15476.1 - 0.35 10.9 2.7 9 6.4 0.4 2.2 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus Mpv17_PMP22 PF04117.12 ELR15477.1 - 4.3e-22 78.1 0.3 8.5e-22 77.2 0.3 1.5 1 0 0 1 1 1 1 Mpv17 / PMP22 family zf-C3HC4_3 PF13920.6 ELR15478.1 - 5.7e-13 48.5 7.1 9e-13 47.9 7.1 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 ELR15478.1 - 1.1e-05 25.2 9.7 2e-05 24.3 9.7 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4 PF00097.25 ELR15478.1 - 1.1e-05 25.2 2.4 1.1e-05 25.2 2.4 1.8 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 ELR15478.1 - 3.3e-05 24.1 6.0 6.8e-05 23.1 6.0 1.6 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.6 ELR15478.1 - 9.4e-05 22.3 4.2 0.00017 21.5 4.2 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_2 PF13923.6 ELR15478.1 - 0.016 15.1 6.4 0.031 14.1 6.4 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Apt1 PF10351.9 ELR15478.1 - 0.45 9.3 7.5 0.56 9.0 7.5 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain Macoilin PF09726.9 ELR15478.1 - 0.99 7.9 8.1 1.3 7.4 8.1 1.1 1 0 0 1 1 1 0 Macoilin family zinc-ribbons_6 PF07191.12 ELR15478.1 - 2.1 8.4 7.4 3.9 7.5 7.4 1.5 1 0 0 1 1 1 0 zinc-ribbons AAA PF00004.29 ELR15479.1 - 7.6e-42 142.9 0.0 1.6e-41 141.8 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Prot_ATP_ID_OB PF16450.5 ELR15479.1 - 4.3e-16 58.6 0.1 8.6e-16 57.6 0.1 1.5 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain AAA_lid_3 PF17862.1 ELR15479.1 - 6.9e-12 45.0 0.3 2e-11 43.5 0.3 1.8 1 0 0 1 1 1 1 AAA+ lid domain AAA_16 PF13191.6 ELR15479.1 - 7.5e-06 26.4 0.5 0.0033 17.8 0.0 2.6 1 1 1 2 2 2 1 AAA ATPase domain AAA_5 PF07728.14 ELR15479.1 - 2.9e-05 24.1 0.1 0.00014 21.9 0.1 2.2 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) RuvB_N PF05496.12 ELR15479.1 - 5.4e-05 23.0 0.0 0.00027 20.7 0.0 2.0 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_2 PF07724.14 ELR15479.1 - 0.00019 21.6 0.0 0.00072 19.7 0.0 1.9 1 1 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.6 ELR15479.1 - 0.00073 19.8 0.6 0.071 13.4 0.1 2.5 1 1 0 2 2 2 1 AAA domain Mg_chelatase PF01078.21 ELR15479.1 - 0.0078 15.6 0.1 0.02 14.3 0.0 1.6 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI JIP_LZII PF16471.5 ELR15479.1 - 0.0091 16.1 1.9 0.0091 16.1 1.9 2.0 2 0 0 2 2 2 1 JNK-interacting protein leucine zipper II PhoH PF02562.16 ELR15479.1 - 0.012 15.1 0.0 0.042 13.3 0.0 1.9 2 0 0 2 2 2 0 PhoH-like protein DUF815 PF05673.13 ELR15479.1 - 0.013 14.7 0.0 0.021 14.0 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF815) ATPase PF06745.13 ELR15479.1 - 0.015 14.6 0.4 0.042 13.2 0.0 1.9 2 0 0 2 2 2 0 KaiC AAA_11 PF13086.6 ELR15479.1 - 0.017 14.9 1.3 0.64 9.7 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_7 PF12775.7 ELR15479.1 - 0.023 14.2 0.0 0.052 13.1 0.0 1.6 1 1 0 1 1 1 0 P-loop containing dynein motor region AAA_24 PF13479.6 ELR15479.1 - 0.036 13.8 0.2 0.14 11.9 0.2 2.1 1 1 0 1 1 1 0 AAA domain IstB_IS21 PF01695.17 ELR15479.1 - 0.037 13.8 0.0 0.072 12.8 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_33 PF13671.6 ELR15479.1 - 0.06 13.5 0.0 0.16 12.2 0.0 1.9 1 0 0 1 1 1 0 AAA domain Sigma54_activat PF00158.26 ELR15479.1 - 0.081 12.6 0.0 0.36 10.5 0.0 2.0 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_25 PF13481.6 ELR15479.1 - 0.09 12.3 0.6 0.55 9.8 0.1 2.3 1 1 1 2 2 2 0 AAA domain AAA_18 PF13238.6 ELR15479.1 - 0.092 13.3 0.2 0.45 11.1 0.0 2.3 2 1 0 2 2 2 0 AAA domain AAA_19 PF13245.6 ELR15479.1 - 0.096 13.0 0.0 0.57 10.5 0.0 2.2 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 ELR15479.1 - 0.13 12.6 0.0 0.27 11.7 0.0 1.5 1 0 0 1 1 1 0 RNA helicase KELK PF15796.5 ELR15479.1 - 0.18 12.3 4.8 0.48 10.9 4.8 1.7 1 0 0 1 1 1 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase Atg14 PF10186.9 ELR15479.1 - 0.41 9.7 2.1 0.64 9.1 2.1 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Sugar_tr PF00083.24 ELR15480.1 - 1.8e-39 135.9 22.7 6.5e-37 127.5 22.7 2.7 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 ELR15480.1 - 1.5e-25 89.9 40.7 8.3e-18 64.4 26.2 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF3021 PF11457.8 ELR15480.1 - 5.2 7.4 19.8 0.1 12.9 6.1 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF3021) PP2C PF00481.21 ELR15481.1 - 6.7e-50 170.1 0.0 1.8e-49 168.7 0.0 1.6 2 0 0 2 2 2 1 Protein phosphatase 2C PUB PF09409.10 ELR15481.1 - 7.2e-16 57.9 0.0 1.3e-15 57.1 0.0 1.4 1 0 0 1 1 1 1 PUB domain PP2C_2 PF13672.6 ELR15481.1 - 1.2e-05 25.0 0.0 9.7e-05 22.1 0.0 2.2 2 1 0 2 2 2 1 Protein phosphatase 2C UPF0561 PF10573.9 ELR15481.1 - 0.016 15.3 0.1 0.031 14.4 0.1 1.4 1 0 0 1 1 1 0 Uncharacterised protein family UPF0561 YscO-like PF16789.5 ELR15481.1 - 5.8 6.9 9.2 1.5 8.8 0.3 2.3 2 0 0 2 2 2 0 YscO-like protein FMO-like PF00743.19 ELR15482.1 - 3e-75 253.7 0.0 1.3e-65 221.9 0.0 2.0 1 1 1 2 2 2 2 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 ELR15482.1 - 3.7e-18 65.8 0.0 2.6e-10 40.1 0.0 3.3 3 1 0 3 3 3 3 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 ELR15482.1 - 8.9e-13 48.1 0.0 6.3e-12 45.3 0.0 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 ELR15482.1 - 4e-09 36.6 0.0 2e-08 34.3 0.0 2.1 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 ELR15482.1 - 1.8e-06 27.4 0.1 9.4e-05 21.8 0.0 2.2 2 0 0 2 2 2 1 Thi4 family Pyr_redox PF00070.27 ELR15482.1 - 1.8e-06 28.4 0.4 0.002 18.7 0.1 2.5 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 ELR15482.1 - 2.2e-06 27.5 0.1 0.00065 19.4 0.1 2.9 2 1 1 3 3 3 1 FAD dependent oxidoreductase K_oxygenase PF13434.6 ELR15482.1 - 2.6e-05 23.5 0.0 0.00033 19.9 0.0 2.2 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) Amino_oxidase PF01593.24 ELR15482.1 - 3.9e-05 23.1 0.1 0.00093 18.6 0.1 2.1 1 1 0 2 2 2 1 Flavin containing amine oxidoreductase FAD_binding_3 PF01494.19 ELR15482.1 - 0.00028 20.3 0.3 0.00047 19.5 0.3 1.3 1 0 0 1 1 1 1 FAD binding domain NAD_binding_9 PF13454.6 ELR15482.1 - 0.00029 20.9 0.3 0.019 15.0 0.1 2.9 2 1 0 2 2 2 1 FAD-NAD(P)-binding HI0933_like PF03486.14 ELR15482.1 - 0.00048 19.0 1.0 0.00078 18.3 1.0 1.3 1 0 0 1 1 1 1 HI0933-like protein FAD_binding_2 PF00890.24 ELR15482.1 - 0.0032 16.6 0.1 0.006 15.7 0.1 1.4 1 0 0 1 1 1 1 FAD binding domain Lycopene_cycl PF05834.12 ELR15482.1 - 0.031 13.4 0.1 0.053 12.6 0.1 1.4 1 0 0 1 1 1 0 Lycopene cyclase protein FAD_oxidored PF12831.7 ELR15482.1 - 0.053 12.9 0.0 0.083 12.2 0.0 1.2 1 0 0 1 1 1 0 FAD dependent oxidoreductase NAD_binding_7 PF13241.6 ELR15482.1 - 0.063 13.7 0.0 3.5 8.1 0.0 2.3 2 0 0 2 2 2 0 Putative NAD(P)-binding GIDA PF01134.22 ELR15482.1 - 0.065 12.3 0.6 0.11 11.5 0.6 1.4 1 0 0 1 1 1 0 Glucose inhibited division protein A Shikimate_DH PF01488.20 ELR15482.1 - 0.16 12.1 0.0 9.1 6.3 0.0 2.3 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase DUF2384 PF09722.10 ELR15484.1 - 0.078 13.0 0.0 0.18 11.9 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2384) PPR_2 PF13041.6 ELR15485.1 - 7.8e-33 112.4 6.0 7.5e-05 22.8 0.0 10.5 8 3 3 11 11 11 7 PPR repeat family PPR_3 PF13812.6 ELR15485.1 - 4.5e-22 77.9 0.9 0.0054 16.8 0.0 7.8 6 3 1 7 7 7 6 Pentatricopeptide repeat domain PPR_long PF17177.4 ELR15485.1 - 1.2e-18 67.3 3.8 3.6e-05 23.2 0.0 6.2 3 2 3 6 6 6 5 Pentacotripeptide-repeat region of PRORP PPR_1 PF12854.7 ELR15485.1 - 6.9e-10 38.5 3.0 0.48 10.2 0.0 8.8 10 0 0 10 10 10 2 PPR repeat PPR PF01535.20 ELR15485.1 - 2.5e-08 33.6 20.0 0.55 10.6 0.0 10.8 11 0 0 11 11 11 1 PPR repeat CCDC53 PF10152.9 ELR15485.1 - 0.023 15.1 1.5 0.052 14.0 1.5 1.7 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex TPR_6 PF13174.6 ELR15485.1 - 0.05 14.2 2.3 6.5 7.6 0.0 4.4 5 0 0 5 5 4 0 Tetratricopeptide repeat TAF4 PF05236.14 ELR15485.1 - 0.26 11.0 22.2 0.87 9.3 22.2 1.8 1 0 0 1 1 1 0 Transcription initiation factor TFIID component TAF4 family RR_TM4-6 PF06459.12 ELR15485.1 - 0.29 10.9 13.1 0.72 9.6 10.1 2.4 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 DUF913 PF06025.12 ELR15485.1 - 0.37 9.7 2.2 0.68 8.8 2.2 1.4 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) DUF4192 PF13830.6 ELR15485.1 - 0.39 10.7 12.8 0.075 13.1 8.7 2.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4192) DUF3801 PF12687.7 ELR15485.1 - 1.3 9.0 12.8 15 5.6 7.9 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3801) Presenilin PF01080.17 ELR15485.1 - 1.9 7.2 6.3 2.9 6.6 6.3 1.3 1 0 0 1 1 1 0 Presenilin NPR3 PF03666.13 ELR15485.1 - 6.9 5.3 8.1 11 4.6 8.1 1.3 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 RPN2_C PF18004.1 ELR15485.1 - 8.5 6.3 13.2 24 4.8 13.2 1.7 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain Orf78 PF06024.12 ELR15486.1 - 0.036 14.3 0.1 0.081 13.2 0.0 1.6 2 0 0 2 2 2 0 Orf78 (ac78) TRAM1 PF08390.11 ELR15486.1 - 5.5 6.7 6.3 0.31 10.7 0.8 1.9 2 1 0 2 2 2 0 TRAM1-like protein IF4E PF01652.18 ELR15487.1 - 1.1e-37 129.3 0.0 1.7e-37 128.6 0.0 1.3 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E DUF2722 PF10846.8 ELR15487.1 - 0.015 14.3 0.0 0.015 14.3 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Spt20 PF12090.8 ELR15487.1 - 3.1 7.4 11.6 4.6 6.8 11.6 1.1 1 0 0 1 1 1 0 Spt20 family CYSTM PF12734.7 ELR15487.1 - 4.3 7.7 8.8 8.4 6.8 8.8 1.5 1 0 0 1 1 1 0 Cysteine-rich TM module stress tolerance zf-CCHC_6 PF15288.6 ELR15488.1 - 0.0025 17.6 0.5 0.0025 17.6 0.5 3.5 4 1 0 4 4 4 1 Zinc knuckle NAM-associated PF14303.6 ELR15488.1 - 0.0051 17.5 13.9 0.0076 17.0 13.9 1.3 1 0 0 1 1 1 1 No apical meristem-associated C-terminal domain CDC27 PF09507.10 ELR15488.1 - 0.093 12.1 18.8 0.19 11.1 18.8 1.5 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Borrelia_P83 PF05262.11 ELR15488.1 - 3.8 5.9 22.4 4.9 5.5 22.4 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein BTB_2 PF02214.22 ELR15489.1 - 7.9e-15 55.0 0.0 2.4e-14 53.4 0.0 1.8 2 1 0 2 2 2 1 BTB/POZ domain BTB_3 PF16017.5 ELR15489.1 - 0.0053 16.9 0.0 0.0098 16.0 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain DUF229 PF02995.17 ELR15491.1 - 1e-35 123.4 0.1 1.4e-35 122.9 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF229) Sulfatase PF00884.23 ELR15491.1 - 0.00015 21.3 0.3 0.0028 17.1 0.3 2.2 1 1 0 1 1 1 1 Sulfatase DUF2353 PF09789.9 ELR15491.1 - 0.034 13.5 0.6 0.058 12.8 0.6 1.3 1 0 0 1 1 1 0 Uncharacterized coiled-coil protein (DUF2353) BRE1 PF08647.11 ELR15491.1 - 0.04 14.0 1.6 0.06 13.4 0.3 1.9 2 0 0 2 2 2 0 BRE1 E3 ubiquitin ligase DUF4407 PF14362.6 ELR15491.1 - 0.23 10.8 7.0 0.37 10.1 7.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) TolA_bind_tri PF16331.5 ELR15491.1 - 0.24 11.5 8.8 0.61 10.2 8.8 1.6 1 0 0 1 1 1 0 TolA binding protein trimerisation DUF4140 PF13600.6 ELR15491.1 - 0.87 10.1 3.8 0.77 10.2 1.1 2.2 2 0 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) DivIC PF04977.15 ELR15491.1 - 3.7 7.4 8.6 0.28 11.0 3.3 2.0 2 0 0 2 2 2 0 Septum formation initiator DUF4381 PF14316.6 ELR15492.1 - 0.00013 22.2 1.0 0.00013 22.2 1.0 2.0 3 0 0 3 3 3 1 Domain of unknown function (DUF4381) LapA_dom PF06305.11 ELR15492.1 - 0.002 17.9 0.4 0.002 17.9 0.4 2.9 2 1 0 2 2 2 1 Lipopolysaccharide assembly protein A domain BatD PF13584.6 ELR15492.1 - 0.01 14.7 1.1 0.012 14.4 1.1 1.1 1 0 0 1 1 1 0 Oxygen tolerance stn_TNFRSF12A PF12191.8 ELR15492.1 - 0.018 15.2 0.1 0.029 14.6 0.1 1.3 1 0 0 1 1 1 0 Tumour necrosis factor receptor stn_TNFRSF12A_TNFR domain YajC PF02699.15 ELR15492.1 - 0.042 13.7 0.1 0.042 13.7 0.1 2.4 2 1 0 2 2 1 0 Preprotein translocase subunit AP3D1 PF06375.11 ELR15492.1 - 0.045 14.0 0.9 0.045 14.0 0.9 1.9 2 0 0 2 2 2 0 AP-3 complex subunit delta-1 FixQ PF05545.11 ELR15492.1 - 0.052 13.5 0.1 0.13 12.2 0.1 1.6 1 0 0 1 1 1 0 Cbb3-type cytochrome oxidase component FixQ Ly49 PF08391.10 ELR15492.1 - 0.056 13.8 1.0 0.45 10.9 0.0 2.3 2 0 0 2 2 2 0 Ly49-like protein, N-terminal region SieB PF14163.6 ELR15492.1 - 0.09 12.3 0.8 0.29 10.6 0.0 2.0 2 0 0 2 2 2 0 Super-infection exclusion protein B Glyco_hydro_4C PF11975.8 ELR15492.1 - 0.097 12.7 0.3 0.14 12.3 0.3 1.2 1 0 0 1 1 1 0 Family 4 glycosyl hydrolase C-terminal domain Peroxin-13_N PF04088.13 ELR15492.1 - 0.12 12.6 0.8 0.25 11.6 0.4 1.6 2 0 0 2 2 2 0 Peroxin 13, N-terminal region Rhabdo_glycop PF00974.18 ELR15492.1 - 0.14 10.6 0.3 0.21 10.0 0.3 1.2 1 0 0 1 1 1 0 Rhabdovirus spike glycoprotein YebO PF13974.6 ELR15492.1 - 0.26 11.4 0.2 0.26 11.4 0.2 2.1 2 0 0 2 2 2 0 YebO-like protein ATP-synt_E PF05680.12 ELR15492.1 - 0.7 10.3 5.5 0.15 12.4 0.9 2.0 2 0 0 2 2 2 0 ATP synthase E chain U-box PF04564.15 ELR15493.1 - 0.042 14.0 0.2 4.2 7.6 0.1 2.3 2 0 0 2 2 2 0 U-box domain SNF2_N PF00176.23 ELR15494.1 - 2e-29 102.4 0.1 4.8e-29 101.2 0.1 1.6 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 ELR15494.1 - 2.7e-05 24.5 0.0 6.5e-05 23.2 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain GDP_Man_Dehyd PF16363.5 ELR15495.1 - 9.3e-60 202.8 0.3 3.4e-59 200.9 0.3 1.7 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 ELR15495.1 - 3.8e-50 170.6 0.1 4.8e-50 170.3 0.1 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 ELR15495.1 - 1.7e-12 46.9 0.0 2.6e-12 46.3 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.12 ELR15495.1 - 2.7e-11 43.1 0.1 3.4e-07 29.7 0.0 2.2 2 0 0 2 2 2 2 Male sterility protein Polysacc_synt_2 PF02719.15 ELR15495.1 - 1.6e-07 30.8 0.0 2.1e-06 27.1 0.0 2.3 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein RmlD_sub_bind PF04321.17 ELR15495.1 - 3.8e-07 29.5 0.0 4.9e-07 29.1 0.0 1.1 1 0 0 1 1 1 1 RmlD substrate binding domain adh_short PF00106.25 ELR15495.1 - 0.0023 17.4 0.0 0.0066 15.9 0.0 1.7 2 0 0 2 2 2 1 short chain dehydrogenase NAD_binding_10 PF13460.6 ELR15495.1 - 0.011 15.6 0.0 0.026 14.4 0.0 1.6 1 1 0 1 1 1 0 NAD(P)H-binding KR PF08659.10 ELR15495.1 - 0.093 12.6 0.0 0.18 11.7 0.0 1.4 1 0 0 1 1 1 0 KR domain F-box PF00646.33 ELR15496.1 - 1.4e-05 24.9 0.4 6e-05 22.8 0.7 1.8 2 0 0 2 2 2 1 F-box domain F-box-like PF12937.7 ELR15496.1 - 1.6e-05 24.7 3.1 6.4e-05 22.8 3.1 2.1 1 0 0 1 1 1 1 F-box-like PLAC8 PF04749.17 ELR15497.1 - 2e-17 64.0 15.4 2.2e-17 63.9 15.4 1.0 1 0 0 1 1 1 1 PLAC8 family Imm8 PF15586.6 ELR15497.1 - 0.14 12.2 0.0 0.19 11.7 0.0 1.2 1 0 0 1 1 1 0 Immunity protein 8 Mur_ligase_M PF08245.12 ELR15498.1 - 7.4e-08 32.6 0.1 2.8e-06 27.5 0.1 2.9 1 1 0 1 1 1 1 Mur ligase middle domain Mur_ligase_C PF02875.21 ELR15498.1 - 0.098 12.9 0.0 0.36 11.1 0.0 2.0 1 0 0 1 1 1 0 Mur ligase family, glutamate ligase domain WD40 PF00400.32 ELR15499.1 - 1.5e-32 111.1 16.4 5.9e-08 33.3 0.0 7.3 7 0 0 7 7 7 6 WD domain, G-beta repeat Bromodomain PF00439.25 ELR15499.1 - 1.3e-17 63.6 0.0 2.4e-17 62.8 0.0 1.4 1 0 0 1 1 1 1 Bromodomain ANAPC4_WD40 PF12894.7 ELR15499.1 - 9.9e-10 38.6 0.3 0.026 14.8 0.0 5.3 3 2 2 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Auxin_resp PF06507.13 ELR15499.1 - 1.3e-05 25.3 0.1 0.00053 20.2 0.1 2.7 1 1 0 1 1 1 1 Auxin response factor WD40_like PF17005.5 ELR15499.1 - 0.0017 17.7 0.0 7 5.9 0.0 3.2 2 1 1 3 3 3 2 WD40-like domain Nup160 PF11715.8 ELR15499.1 - 0.034 12.8 4.9 4.9 5.7 0.2 3.7 1 1 3 4 4 4 0 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 ELR15499.1 - 0.23 10.4 0.1 4.4 6.2 0.0 2.7 3 0 0 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein DUF3395 PF11875.8 ELR15500.1 - 1.8e-05 24.7 0.0 0.12 12.3 0.0 2.5 3 0 0 3 3 3 2 Domain of unknown function (DUF3395) CW_7 PF08230.11 ELR15500.1 - 0.3 10.9 1.0 18 5.1 0.1 2.7 3 0 0 3 3 3 0 CW_7 repeat F-box-like PF12937.7 ELR15501.1 - 2.5e-08 33.7 0.1 4.5e-08 32.9 0.1 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ELR15501.1 - 0.12 12.3 0.0 0.25 11.2 0.0 1.5 1 0 0 1 1 1 0 F-box domain RasGEF PF00617.19 ELR15503.1 - 7.9e-37 127.2 1.8 5.8e-20 72.2 1.0 2.5 1 1 1 2 2 2 2 RasGEF domain RasGEF_N PF00618.20 ELR15503.1 - 0.00065 19.9 0.0 0.045 14.0 0.0 3.3 2 2 1 3 3 3 1 RasGEF N-terminal motif SR-25 PF10500.9 ELR15503.1 - 0.02 14.5 9.4 0.033 13.8 9.4 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein SEO_N PF14576.6 ELR15503.1 - 0.09 11.9 0.1 0.16 11.1 0.1 1.4 1 0 0 1 1 1 0 Sieve element occlusion N-terminus Mur_ligase_M PF08245.12 ELR15504.1 - 3.9e-05 23.7 0.1 0.00053 20.0 0.1 2.1 1 1 0 1 1 1 1 Mur ligase middle domain CBS PF00571.28 ELR15505.1 - 9.2e-20 70.9 5.5 5.3e-07 30.0 0.0 3.9 4 0 0 4 4 4 3 CBS domain Cellulase PF00150.18 ELR15506.1 - 1.7e-73 247.5 13.6 3.4e-39 135.0 6.0 2.1 2 0 0 2 2 2 2 Cellulase (glycosyl hydrolase family 5) Ras PF00071.22 ELR15509.1 - 6.9e-33 113.5 0.0 9.8e-33 113.0 0.0 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR15509.1 - 5.3e-22 78.3 0.0 8.5e-22 77.6 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase FYVE PF01363.21 ELR15509.1 - 7.4e-16 58.0 8.3 1.5e-15 57.1 8.3 1.5 1 0 0 1 1 1 1 FYVE zinc finger Arf PF00025.21 ELR15509.1 - 1e-13 51.1 0.0 1.6e-13 50.5 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 ELR15509.1 - 0.012 15.0 0.0 0.02 14.3 0.0 1.3 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 ELR15509.1 - 0.014 15.0 0.0 0.023 14.2 0.0 1.3 1 0 0 1 1 1 0 Elongation factor Tu GTP binding domain FYVE_2 PF02318.16 ELR15509.1 - 5.7 7.2 8.2 0.24 11.6 2.2 1.8 2 0 0 2 2 2 0 FYVE-type zinc finger SH3_9 PF14604.6 ELR15510.1 - 5.5e-09 35.8 0.0 1.6e-08 34.3 0.0 1.8 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 ELR15510.1 - 8.2e-09 34.9 0.0 2e-08 33.7 0.0 1.6 1 0 0 1 1 1 1 SH3 domain PH PF00169.29 ELR15510.1 - 5.3e-07 30.1 0.2 1.5e-06 28.7 0.2 1.7 1 0 0 1 1 1 1 PH domain SH3_2 PF07653.17 ELR15510.1 - 0.00032 20.3 0.0 0.00065 19.3 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain ERM PF00769.19 ELR15510.1 - 0.31 10.8 44.6 0.13 12.0 16.2 3.4 3 0 0 3 3 3 0 Ezrin/radixin/moesin family TGT PF01702.18 ELR15511.1 - 1.8e-101 339.8 0.1 2e-72 244.3 0.0 2.2 2 0 0 2 2 2 2 Queuine tRNA-ribosyltransferase Cullin_binding PF03556.15 ELR15512.1 - 1.8e-23 83.2 0.0 2.7e-23 82.7 0.0 1.2 1 0 0 1 1 1 1 Cullin binding Ras PF00071.22 ELR15513.1 - 1.7e-16 60.3 0.1 4.4e-16 58.9 0.1 1.7 1 0 0 1 1 1 1 Ras family CAF-1_p150 PF11600.8 ELR15513.1 - 0.087 12.5 64.0 0.1 12.3 52.4 2.8 2 0 0 2 2 2 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal Cupin_4 PF08007.12 ELR15514.1 - 1.8e-50 172.2 0.4 3.3e-44 151.7 0.0 2.4 2 0 0 2 2 2 2 Cupin superfamily protein 2OG-FeII_Oxy_4 PF13661.6 ELR15514.1 - 9.1e-15 55.1 0.0 2.2e-14 53.9 0.0 1.7 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_3 PF13640.6 ELR15514.1 - 1.5e-14 54.6 0.0 2.5e-13 50.7 0.0 2.6 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily Cupin_8 PF13621.6 ELR15514.1 - 2e-07 31.0 0.0 7.7e-06 25.8 0.0 2.5 1 1 0 1 1 1 1 Cupin-like domain Cupin_3 PF05899.12 ELR15514.1 - 0.031 14.0 0.0 9 6.1 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF861) Cupin_2 PF07883.11 ELR15514.1 - 0.044 13.5 0.0 1.2 8.9 0.0 2.5 2 0 0 2 2 2 0 Cupin domain LANC_like PF05147.13 ELR15516.1 - 2.3e-56 190.9 0.0 3.1e-56 190.5 0.0 1.0 1 0 0 1 1 1 1 Lanthionine synthetase C-like protein TPR_8 PF13181.6 ELR15516.1 - 0.00062 19.8 0.0 1.2 9.5 0.0 2.8 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.17 ELR15516.1 - 0.0037 17.3 3.9 0.21 11.8 0.1 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_MalT PF17874.1 ELR15516.1 - 0.029 13.8 0.8 0.075 12.4 0.8 1.7 1 1 0 1 1 1 0 MalT-like TPR region TPR_12 PF13424.6 ELR15516.1 - 0.12 12.7 5.3 9 6.7 0.2 3.7 3 0 0 3 3 3 0 Tetratricopeptide repeat PfkB PF00294.24 ELR15517.1 - 6.8e-24 84.7 0.0 9.4e-24 84.2 0.0 1.1 1 0 0 1 1 1 1 pfkB family carbohydrate kinase AMMECR1 PF01871.17 ELR15518.1 - 2.1e-39 134.8 0.0 2.4e-39 134.6 0.0 1.0 1 0 0 1 1 1 1 AMMECR1 Pkinase_Tyr PF07714.17 ELR15519.1 - 1.3e-71 241.0 0.0 2.2e-71 240.2 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ELR15519.1 - 1.2e-40 139.5 0.7 4.1e-40 137.8 0.0 2.1 2 0 0 2 2 2 1 Protein kinase domain Ank_5 PF13857.6 ELR15519.1 - 1.4e-26 92.2 3.0 7.5e-12 45.2 0.1 4.1 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank PF00023.30 ELR15519.1 - 8.4e-24 82.9 2.6 1.2e-06 28.7 0.0 5.3 4 0 0 4 4 4 4 Ankyrin repeat Ank_2 PF12796.7 ELR15519.1 - 2.4e-23 82.5 0.1 1.2e-11 45.1 0.0 3.4 2 2 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ELR15519.1 - 1.1e-22 80.1 0.4 1.8e-10 41.1 0.1 3.8 3 1 1 4 4 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 ELR15519.1 - 1e-21 74.7 2.3 5.3e-07 29.4 0.0 5.3 5 0 0 5 5 5 3 Ankyrin repeat SAM_1 PF00536.30 ELR15519.1 - 4.2e-09 36.7 0.1 9.4e-09 35.6 0.1 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 ELR15519.1 - 9.3e-05 22.5 0.0 0.00023 21.2 0.0 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Kdo PF06293.14 ELR15519.1 - 0.0013 18.1 2.9 0.14 11.5 0.0 2.3 2 0 0 2 2 2 2 Lipopolysaccharide kinase (Kdo/WaaP) family PEGA PF08308.11 ELR15519.1 - 0.077 12.9 0.0 1.9 8.4 0.0 2.6 2 0 0 2 2 2 0 PEGA domain DHHC PF01529.20 ELR15521.1 - 2.7e-05 24.3 5.5 2.7e-05 24.3 5.5 2.3 2 1 0 2 2 2 1 DHHC palmitoyltransferase CDC45 PF02724.14 ELR15521.1 - 0.014 13.7 0.2 0.021 13.1 0.2 1.2 1 0 0 1 1 1 0 CDC45-like protein TMEM40 PF15817.5 ELR15521.1 - 0.03 14.1 1.5 3.4 7.5 0.0 2.5 2 0 0 2 2 2 0 Transmembrane protein 40 family SR-25 PF10500.9 ELR15521.1 - 0.048 13.3 7.2 0.065 12.8 7.2 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein AF-4 PF05110.13 ELR15521.1 - 0.47 8.5 7.6 0.63 8.1 7.6 1.0 1 0 0 1 1 1 0 AF-4 proto-oncoprotein CCDC106 PF15794.5 ELR15521.1 - 3.5 7.3 6.1 5.5 6.6 6.1 1.2 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 YL1 PF05764.13 ELR15521.1 - 8.3 6.5 13.5 13 5.8 13.5 1.2 1 0 0 1 1 1 0 YL1 nuclear protein F-box-like PF12937.7 ELR15522.1 - 0.001 18.9 0.2 0.0023 17.8 0.2 1.7 1 0 0 1 1 1 1 F-box-like zf-rbx1 PF12678.7 ELR15522.1 - 0.004 17.4 0.6 0.0083 16.4 0.6 1.4 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_2 PF13639.6 ELR15522.1 - 0.018 15.4 0.6 0.034 14.5 0.6 1.4 1 0 0 1 1 1 0 Ring finger domain zf-C3HC4_2 PF13923.6 ELR15522.1 - 0.064 13.1 0.1 0.13 12.1 0.1 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Zn_ribbon_17 PF17120.5 ELR15522.1 - 0.087 12.5 0.3 0.17 11.5 0.3 1.4 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type F-box PF00646.33 ELR15522.1 - 0.092 12.7 0.1 0.18 11.8 0.1 1.5 1 0 0 1 1 1 0 F-box domain zf-RING_11 PF17123.5 ELR15522.1 - 1.2 9.0 3.6 0.41 10.4 0.5 1.8 2 0 0 2 2 2 0 RING-like zinc finger TatD_DNase PF01026.21 ELR15523.1 - 3.3e-26 92.2 0.7 4.6e-22 78.6 0.1 2.1 1 1 1 2 2 2 2 TatD related DNase SWIRM-assoc_1 PF16495.5 ELR15524.1 - 0.01 15.8 21.3 0.065 13.2 0.8 4.0 1 1 4 5 5 5 0 SWIRM-associated region 1 APG6_N PF17675.1 ELR15524.1 - 0.022 15.3 35.4 0.065 13.8 22.9 2.1 1 1 1 2 2 2 0 Apg6 coiled-coil region Spc7 PF08317.11 ELR15524.1 - 0.23 10.3 27.1 0.025 13.5 16.3 2.0 1 1 1 2 2 2 0 Spc7 kinetochore protein TPR_MLP1_2 PF07926.12 ELR15524.1 - 0.31 11.1 30.9 0.8 9.8 21.7 3.1 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein Atg14 PF10186.9 ELR15524.1 - 0.67 9.0 17.6 0.27 10.3 14.9 1.5 1 1 1 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF3450 PF11932.8 ELR15524.1 - 1 8.6 17.4 1 8.6 5.6 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) TMPIT PF07851.13 ELR15524.1 - 5.5 6.1 10.5 6.3 5.9 10.5 1.2 1 0 0 1 1 1 0 TMPIT-like protein RNA_lig_T4_1 PF09511.10 ELR15525.1 - 3e-21 76.3 0.0 4.8e-21 75.6 0.0 1.3 1 0 0 1 1 1 1 RNA ligase Poxvirus_B22R_N PF13169.6 ELR15525.1 - 0.0032 17.9 0.1 0.013 16.0 0.1 2.0 1 1 0 1 1 1 1 Poxvirus B22R protein N-terminal DUF1566 PF07603.11 ELR15525.1 - 0.006 17.0 0.0 0.012 15.9 0.0 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF1566) SIR2_2 PF13289.6 ELR15526.1 - 4.6e-09 36.5 0.0 7.9e-09 35.8 0.0 1.4 1 0 0 1 1 1 1 SIR2-like domain DUF86 PF01934.17 ELR15526.1 - 0.13 12.2 0.0 0.22 11.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function DUF86 EF-hand_1 PF00036.32 ELR15528.1 - 3.5e-05 23.0 0.1 0.0057 16.1 0.0 3.2 3 0 0 3 3 3 1 EF hand EF-hand_5 PF13202.6 ELR15528.1 - 8.7e-05 21.8 0.7 0.042 13.3 0.0 3.2 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.6 ELR15528.1 - 0.00017 21.3 0.3 0.0098 15.8 0.1 3.3 3 1 0 3 3 3 1 EF-hand domain EF-hand_7 PF13499.6 ELR15528.1 - 0.00076 19.9 0.0 0.0051 17.2 0.0 2.3 2 1 0 2 2 2 1 EF-hand domain pair EF-hand_8 PF13833.6 ELR15528.1 - 0.012 15.4 0.0 0.048 13.5 0.0 2.0 2 0 0 2 2 2 0 EF-hand domain pair PRA-PH PF01503.17 ELR15528.1 - 0.025 15.0 0.5 0.68 10.4 0.0 2.3 2 1 0 2 2 2 0 Phosphoribosyl-ATP pyrophosphohydrolase Usp PF00582.26 ELR15529.1 - 2.5e-07 31.3 10.2 3.2e-06 27.7 0.2 3.5 2 1 2 4 4 4 2 Universal stress protein family Rhodanese PF00581.20 ELR15529.1 - 0.035 14.6 0.0 0.099 13.2 0.0 1.7 1 0 0 1 1 1 0 Rhodanese-like domain UBX PF00789.20 ELR15530.1 - 4.5e-18 65.2 0.0 6.8e-18 64.7 0.0 1.3 1 0 0 1 1 1 1 UBX domain Presenilin PF01080.17 ELR15530.1 - 0.43 9.3 2.6 0.5 9.1 2.6 1.1 1 0 0 1 1 1 0 Presenilin DUF5401 PF17380.2 ELR15530.1 - 1.9 6.5 25.2 2.3 6.2 25.2 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5401) V_ATPase_I PF01496.19 ELR15530.1 - 2.8 5.7 4.3 3.4 5.5 4.3 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family AAA_11 PF13086.6 ELR15530.1 - 3.1 7.5 7.2 4 7.1 7.2 1.1 1 0 0 1 1 1 0 AAA domain CDC45 PF02724.14 ELR15530.1 - 6.1 5.0 9.8 6.8 4.8 9.8 1.0 1 0 0 1 1 1 0 CDC45-like protein 2OG-FeII_Oxy_3 PF13640.6 ELR15531.1 - 6.2e-06 27.0 0.0 1.3e-05 26.0 0.0 1.6 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DNMT1-RFD PF12047.8 ELR15532.1 - 7.6e-15 55.2 0.0 9.2e-15 54.9 0.0 1.1 1 0 0 1 1 1 1 Cytosine specific DNA methyltransferase replication foci domain MFS_1 PF07690.16 ELR15534.1 - 6.8e-23 81.2 31.7 1.7e-11 43.7 19.7 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily Amidase PF01425.21 ELR15534.1 - 0.016 14.1 0.1 0.024 13.6 0.1 1.1 1 0 0 1 1 1 0 Amidase Adeno_terminal PF02459.15 ELR15534.1 - 2.9 6.2 4.1 4.2 5.7 4.1 1.1 1 0 0 1 1 1 0 Adenoviral DNA terminal protein DNA_methylase PF00145.17 ELR15535.1 - 5.9e-49 167.2 0.0 2.9e-48 164.9 0.0 2.2 2 0 0 2 2 2 1 C-5 cytosine-specific DNA methylase DNMT1-RFD PF12047.8 ELR15535.1 - 1.4e-28 99.7 6.2 2.3e-13 50.4 3.5 3.7 3 1 0 3 3 3 2 Cytosine specific DNA methyltransferase replication foci domain BAH PF01426.18 ELR15535.1 - 4.6e-23 81.4 1.1 1.6e-11 44.1 0.3 2.9 2 0 0 2 2 2 2 BAH domain Mpp10 PF04006.12 ELR15535.1 - 0.003 16.1 32.2 0.0063 15.0 32.2 1.5 1 0 0 1 1 1 1 Mpp10 protein Connexin PF00029.19 ELR15535.1 - 0.26 11.0 5.4 1 9.1 0.6 2.5 2 0 0 2 2 2 0 Connexin TFIIF_alpha PF05793.12 ELR15535.1 - 2.9 6.4 42.2 0.46 9.0 8.7 4.1 4 0 0 4 4 4 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) BUD22 PF09073.10 ELR15535.1 - 9.5 5.4 45.0 0.0083 15.5 25.5 3.4 3 0 0 3 3 3 0 BUD22 Ras PF00071.22 ELR15536.1 - 4.7e-45 153.1 0.0 1.2e-44 151.8 0.0 1.7 2 0 0 2 2 2 1 Ras family Roc PF08477.13 ELR15536.1 - 5.3e-12 46.0 0.0 1e-11 45.1 0.0 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR15536.1 - 0.0021 17.5 0.0 0.0039 16.7 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family RabGAP-TBC PF00566.18 ELR15537.1 - 7.2e-43 146.7 0.4 4.2e-21 75.6 0.0 2.1 2 0 0 2 2 2 2 Rab-GTPase-TBC domain FTHFS PF01268.19 ELR15538.1 - 7e-256 849.8 0.0 7.9e-256 849.6 0.0 1.0 1 0 0 1 1 1 1 Formate--tetrahydrofolate ligase MSC PF09402.10 ELR15540.1 - 5.4e-13 49.1 6.8 1.7e-12 47.4 7.0 1.6 1 1 0 1 1 1 1 Man1-Src1p-C-terminal domain Thymopoietin PF08198.11 ELR15540.1 - 3e-06 26.7 0.1 6.8e-06 25.6 0.1 1.5 1 0 0 1 1 1 1 Thymopoietin protein HeH PF12949.7 ELR15540.1 - 0.0013 18.4 0.0 0.0042 16.8 0.0 1.9 1 0 0 1 1 1 1 HeH/LEM domain IMUP PF15761.5 ELR15540.1 - 0.083 13.6 3.4 0.27 11.9 3.4 1.8 1 0 0 1 1 1 0 Immortalisation up-regulated protein SAP18 PF06487.12 ELR15541.1 - 3.8e-41 140.6 0.0 5e-41 140.2 0.0 1.2 1 0 0 1 1 1 1 Sin3 associated polypeptide p18 (SAP18) Kelch_3 PF13415.6 ELR15542.1 - 1.2e-42 143.4 11.5 1.4e-10 41.2 0.3 7.3 7 0 0 7 7 7 5 Galactose oxidase, central domain Kelch_1 PF01344.25 ELR15542.1 - 2.3e-40 135.9 4.2 5.1e-11 42.0 0.0 6.4 6 0 0 6 6 6 6 Kelch motif Kelch_4 PF13418.6 ELR15542.1 - 4.2e-38 129.1 15.0 2.9e-08 33.6 0.1 7.1 7 0 0 7 7 7 6 Galactose oxidase, central domain Kelch_6 PF13964.6 ELR15542.1 - 2e-36 123.1 10.2 8.5e-09 35.4 0.1 6.8 5 2 2 7 7 7 6 Kelch motif Kelch_5 PF13854.6 ELR15542.1 - 2.4e-34 116.8 2.5 5.3e-08 32.7 0.0 7.2 7 0 0 7 7 7 5 Kelch motif Kelch_2 PF07646.15 ELR15542.1 - 8.8e-29 98.4 8.9 3.7e-07 29.8 0.0 7.0 6 1 0 6 6 6 6 Kelch motif PQQ_3 PF13570.6 ELR15542.1 - 0.035 14.6 3.5 0.66 10.5 0.1 3.6 3 1 0 3 3 3 0 PQQ-like domain Gallidermin PF02052.15 ELR15542.1 - 0.054 13.8 0.2 1.9 8.9 0.0 3.3 3 0 0 3 3 3 0 Gallidermin SR-25 PF10500.9 ELR15542.1 - 0.073 12.7 11.7 0.11 12.1 11.7 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein DZR PF12773.7 ELR15543.1 - 0.0003 20.8 10.9 0.00052 20.0 10.9 1.4 1 0 0 1 1 1 1 Double zinc ribbon APG6_N PF17675.1 ELR15543.1 - 0.0037 17.8 13.5 0.54 10.8 0.2 2.3 2 0 0 2 2 2 2 Apg6 coiled-coil region WH2 PF02205.20 ELR15543.1 - 0.022 14.6 0.1 0.054 13.3 0.1 1.6 1 0 0 1 1 1 0 WH2 motif GAS PF13851.6 ELR15543.1 - 0.57 9.5 11.1 0.096 12.0 2.3 2.4 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding GATA PF00320.27 ELR15543.1 - 1.2 8.8 13.7 7.8 6.2 0.3 4.4 2 1 2 4 4 4 0 GATA zinc finger Zn-ribbon_8 PF09723.10 ELR15543.1 - 1.5 9.0 5.3 0.97 9.6 1.7 2.4 1 1 1 2 2 2 0 Zinc ribbon domain Takusan PF04822.13 ELR15543.1 - 2.6 8.0 5.1 1.4 8.8 0.9 2.6 2 0 0 2 2 2 0 Takusan Peptidase_M14 PF00246.24 ELR15544.1 - 3.2e-67 227.4 0.0 4e-67 227.0 0.0 1.1 1 0 0 1 1 1 1 Zinc carboxypeptidase AstE_AspA PF04952.14 ELR15544.1 - 2.1e-06 27.1 0.0 8.9e-06 25.0 0.1 1.8 2 0 0 2 2 2 1 Succinylglutamate desuccinylase / Aspartoacylase family CarboxypepD_reg PF13620.6 ELR15544.1 - 0.005 17.1 0.0 0.0093 16.2 0.0 1.5 1 0 0 1 1 1 1 Carboxypeptidase regulatory-like domain DUF2817 PF10994.8 ELR15544.1 - 0.019 14.4 0.1 0.032 13.7 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2817) RhoGEF PF00621.20 ELR15548.1 - 3.7e-51 174.0 0.0 5.5e-51 173.4 0.0 1.3 1 0 0 1 1 1 1 RhoGEF domain IQ_SEC7_PH PF16453.5 ELR15548.1 - 0.0093 15.9 0.0 0.019 14.9 0.0 1.4 1 0 0 1 1 1 1 PH domain IQ PF00612.27 ELR15548.1 - 0.031 14.1 2.7 0.036 13.9 0.6 2.3 2 0 0 2 2 2 0 IQ calmodulin-binding motif COG7 PF10191.9 ELR15548.1 - 0.12 10.6 0.1 0.18 10.0 0.1 1.2 1 0 0 1 1 1 0 Golgi complex component 7 (COG7) Glyco_hydro_32N PF00251.20 ELR15550.1 - 4.9e-71 239.8 2.5 4.9e-71 239.8 2.5 1.4 2 0 0 2 2 2 1 Glycosyl hydrolases family 32 N-terminal domain Glyco_hydro_32C PF08244.12 ELR15550.1 - 7.6e-19 68.3 0.0 2.1e-18 66.8 0.0 1.7 2 1 0 2 2 2 1 Glycosyl hydrolases family 32 C terminal PAN_4 PF14295.6 ELR15550.1 - 4.3e-10 39.3 0.8 8e-10 38.5 0.8 1.5 1 0 0 1 1 1 1 PAN domain PAN_2 PF08276.11 ELR15550.1 - 0.11 12.6 0.1 0.3 11.2 0.1 1.6 1 0 0 1 1 1 0 PAN-like domain zf-MIZ PF02891.20 ELR15551.1 - 8.3e-20 70.3 6.9 1.5e-19 69.5 6.9 1.4 1 0 0 1 1 1 1 MIZ/SP-RING zinc finger PINIT PF14324.6 ELR15551.1 - 2.2e-07 31.3 2.4 2.6e-07 31.1 0.2 2.0 1 1 1 2 2 2 1 PINIT domain zf-Nse PF11789.8 ELR15551.1 - 0.00023 20.9 2.3 0.00052 19.8 2.3 1.6 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-Sec23_Sec24 PF04810.15 ELR15551.1 - 0.4 10.8 4.0 0.43 10.7 2.1 2.0 2 0 0 2 2 2 0 Sec23/Sec24 zinc finger NHL PF01436.21 ELR15552.1 - 2.5e-26 90.3 2.9 2.5e-05 24.1 0.1 6.9 6 0 0 6 6 6 5 NHL repeat Thioredoxin_8 PF13905.6 ELR15552.1 - 1.2e-10 41.6 0.1 2.5e-10 40.5 0.1 1.6 1 0 0 1 1 1 1 Thioredoxin-like AhpC-TSA PF00578.21 ELR15552.1 - 1.5e-06 28.2 0.0 3.3e-06 27.0 0.0 1.6 1 0 0 1 1 1 1 AhpC/TSA family SGL PF08450.12 ELR15552.1 - 1.7e-05 24.5 0.1 0.25 10.9 0.0 4.4 2 1 2 5 5 5 1 SMP-30/Gluconolactonase/LRE-like region Redoxin PF08534.10 ELR15552.1 - 2.2e-05 24.2 0.0 0.0002 21.1 0.0 2.5 2 0 0 2 2 2 1 Redoxin Thioredoxin PF00085.20 ELR15552.1 - 0.00029 20.8 0.0 0.0084 16.1 0.1 2.4 2 0 0 2 2 2 1 Thioredoxin Arylesterase PF01731.20 ELR15552.1 - 0.028 14.6 0.0 3.6 7.8 0.0 3.6 3 0 0 3 3 3 0 Arylesterase DUF5128 PF17170.4 ELR15552.1 - 0.037 13.2 0.0 0.29 10.3 0.0 2.0 2 0 0 2 2 2 0 6-bladed beta-propeller Phytase-like PF13449.6 ELR15552.1 - 0.087 12.7 0.0 2.5 8.0 0.0 2.9 2 1 0 2 2 2 0 Esterase-like activity of phytase CorA PF01544.18 ELR15553.1 - 0.00019 20.8 10.6 0.00019 20.8 10.6 1.8 1 1 0 2 2 2 1 CorA-like Mg2+ transporter protein Rhabdo_glycop PF00974.18 ELR15553.1 - 0.0051 15.3 0.1 0.0074 14.8 0.1 1.1 1 0 0 1 1 1 1 Rhabdovirus spike glycoprotein Cwf_Cwc_15 PF04889.12 ELR15553.1 - 0.0075 16.0 22.0 0.0075 16.0 22.0 4.5 4 1 0 4 4 4 1 Cwf15/Cwc15 cell cycle control protein Ni_hydr_CYTB PF01292.20 ELR15553.1 - 0.014 15.0 0.9 0.028 14.0 0.9 1.4 1 0 0 1 1 1 0 Prokaryotic cytochrome b561 DUF2207 PF09972.9 ELR15553.1 - 0.024 13.4 0.0 0.024 13.4 0.0 2.0 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) LapA_dom PF06305.11 ELR15553.1 - 0.046 13.5 0.5 0.046 13.5 0.5 3.1 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain SIT PF15330.6 ELR15553.1 - 0.75 10.3 2.1 33 5.0 0.0 3.7 3 0 0 3 3 3 0 SHP2-interacting transmembrane adaptor protein, SIT DUF2721 PF11026.8 ELR15553.1 - 8.5 6.3 5.2 4.1 7.3 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2721) Ank_2 PF12796.7 ELR15554.1 - 4.8e-30 104.0 2.1 1.6e-12 47.8 0.0 4.0 2 2 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_5 PF13857.6 ELR15554.1 - 5.2e-21 74.4 3.1 8.4e-06 26.0 0.1 4.6 3 1 1 4 4 4 4 Ankyrin repeats (many copies) Ank_4 PF13637.6 ELR15554.1 - 1.1e-19 70.5 0.5 4.4e-06 27.1 0.0 4.9 2 1 3 5 5 5 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 ELR15554.1 - 4.8e-18 63.4 0.8 5e-07 29.5 0.0 5.1 5 0 0 5 5 5 3 Ankyrin repeat Ank PF00023.30 ELR15554.1 - 1.7e-17 63.0 4.3 2.4e-05 24.6 0.2 5.0 5 0 0 5 5 5 4 Ankyrin repeat SRP54 PF00448.22 ELR15555.1 - 9.5e-70 234.2 0.3 1.5e-69 233.6 0.3 1.3 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain SRP_SPB PF02978.19 ELR15555.1 - 1.1e-29 102.9 5.5 8.6e-29 100.1 0.0 3.6 3 0 0 3 3 3 1 Signal peptide binding domain SRP54_N PF02881.19 ELR15555.1 - 2.6e-12 46.8 1.1 6.4e-12 45.5 1.1 1.7 1 0 0 1 1 1 1 SRP54-type protein, helical bundle domain cobW PF02492.19 ELR15555.1 - 5.1e-09 35.9 0.2 4.6e-07 29.6 0.1 3.4 3 1 0 3 3 3 1 CobW/HypB/UreG, nucleotide-binding domain MeaB PF03308.16 ELR15555.1 - 1.6e-06 27.3 0.1 4.2e-06 25.9 0.0 1.7 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_22 PF13401.6 ELR15555.1 - 5.7e-05 23.4 0.2 0.0034 17.7 0.0 2.7 3 0 0 3 3 3 1 AAA domain AAA_16 PF13191.6 ELR15555.1 - 8.7e-05 23.0 0.0 0.00024 21.5 0.0 1.8 1 0 0 1 1 1 1 AAA ATPase domain CbiA PF01656.23 ELR15555.1 - 0.00012 22.1 0.0 0.00032 20.7 0.0 1.9 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain MobB PF03205.14 ELR15555.1 - 0.00051 19.9 0.0 0.0012 18.7 0.0 1.7 1 0 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B AAA_30 PF13604.6 ELR15555.1 - 0.00059 19.6 0.1 0.0014 18.4 0.1 1.7 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.6 ELR15555.1 - 0.00067 20.1 0.3 0.0026 18.2 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.6 ELR15555.1 - 0.0011 19.1 2.3 0.0031 17.7 0.3 2.5 2 1 0 2 2 2 1 AAA domain AAA_25 PF13481.6 ELR15555.1 - 0.0015 18.2 0.3 0.004 16.8 0.1 1.8 2 0 0 2 2 1 1 AAA domain SRPRB PF09439.10 ELR15555.1 - 0.0016 17.9 0.1 2.6 7.5 0.0 2.7 3 0 0 3 3 3 2 Signal recognition particle receptor beta subunit AAA_28 PF13521.6 ELR15555.1 - 0.002 18.4 0.1 0.0051 17.1 0.1 1.7 1 0 0 1 1 1 1 AAA domain MMR_HSR1 PF01926.23 ELR15555.1 - 0.003 17.6 0.1 0.022 14.9 0.1 2.3 1 1 0 1 1 1 1 50S ribosome-binding GTPase Zeta_toxin PF06414.12 ELR15555.1 - 0.0098 15.2 0.4 0.017 14.4 0.0 1.6 2 0 0 2 2 1 1 Zeta toxin APS_kinase PF01583.20 ELR15555.1 - 0.011 15.6 0.1 0.025 14.5 0.1 1.6 1 0 0 1 1 1 0 Adenylylsulphate kinase ResIII PF04851.15 ELR15555.1 - 0.051 13.6 0.0 0.09 12.8 0.0 1.5 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit AAA PF00004.29 ELR15555.1 - 0.095 13.1 0.9 0.86 10.0 0.1 2.7 3 1 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) NTPase_1 PF03266.15 ELR15555.1 - 0.11 12.4 0.0 0.29 11.0 0.0 1.7 1 0 0 1 1 1 0 NTPase Phage_TAC_11 PF11836.8 ELR15555.1 - 0.15 12.2 2.6 11 6.2 0.1 3.7 4 0 0 4 4 4 0 Phage tail tube protein, GTA-gp10 Aldedh PF00171.22 ELR15556.1 - 1.3e-118 396.5 0.0 1.6e-118 396.2 0.0 1.1 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Mito_carr PF00153.27 ELR15557.1 - 0.00037 20.3 0.1 0.03 14.2 0.0 3.1 3 1 0 3 3 3 1 Mitochondrial carrier protein F-box-like PF12937.7 ELR15558.1 - 9.1e-06 25.5 0.2 2.7e-05 24.0 0.2 1.8 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ELR15558.1 - 0.0063 16.4 0.2 0.012 15.4 0.2 1.5 1 0 0 1 1 1 1 F-box domain CDC45 PF02724.14 ELR15558.1 - 0.7 8.1 11.4 0.082 11.2 1.9 2.1 2 0 0 2 2 2 0 CDC45-like protein PBP1_TM PF14812.6 ELR15558.1 - 3.5 8.0 26.5 2.2 8.7 7.7 2.7 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal FAM176 PF14851.6 ELR15558.1 - 5.1 6.7 12.1 0.26 11.0 1.1 2.5 2 0 0 2 2 2 0 FAM176 family SGT1 PF07093.11 ELR15559.1 - 2.9e-142 475.1 23.9 9.4e-116 387.6 1.0 2.1 1 1 1 2 2 2 2 SGT1 protein CoA_trans PF01144.23 ELR15561.1 - 7.5e-116 385.1 0.2 8e-75 251.0 0.0 2.0 2 0 0 2 2 2 2 Coenzyme A transferase HSP20 PF00011.21 ELR15562.1 - 3.9e-10 39.8 0.0 4.7e-10 39.5 0.0 1.1 1 0 0 1 1 1 1 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 ELR15562.1 - 2.3e-05 23.9 0.1 3.6e-05 23.2 0.1 1.4 1 1 0 1 1 1 1 HSP20-like domain found in ArsA AAA_25 PF13481.6 ELR15563.1 - 3.8e-21 75.6 0.0 6.4e-21 74.8 0.0 1.3 1 0 0 1 1 1 1 AAA domain DnaB_C PF03796.15 ELR15563.1 - 2.1e-10 40.3 0.0 3.2e-10 39.8 0.0 1.3 1 0 0 1 1 1 1 DnaB-like helicase C terminal domain Toprim_2 PF13155.6 ELR15563.1 - 3.3e-09 37.0 0.0 3.7e-07 30.5 0.0 2.7 2 0 0 2 2 2 1 Toprim-like Toprim_4 PF13662.6 ELR15563.1 - 3.2e-06 27.5 0.0 2.4e-05 24.7 0.0 2.4 3 0 0 3 3 2 1 Toprim domain AAA_22 PF13401.6 ELR15563.1 - 4.1e-06 27.1 0.0 1.1e-05 25.7 0.0 1.7 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 ELR15563.1 - 5e-05 23.8 0.0 0.0001 22.7 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain RsgA_GTPase PF03193.16 ELR15563.1 - 0.00085 19.3 0.0 0.0021 18.0 0.0 1.6 1 0 0 1 1 1 1 RsgA GTPase ATPase PF06745.13 ELR15563.1 - 0.0023 17.3 0.0 0.0039 16.6 0.0 1.2 1 0 0 1 1 1 1 KaiC ABC_tran PF00005.27 ELR15563.1 - 0.0071 16.9 0.0 0.014 15.9 0.0 1.6 1 0 0 1 1 1 1 ABC transporter AAA_23 PF13476.6 ELR15563.1 - 0.01 16.3 0.1 0.023 15.2 0.1 1.5 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.6 ELR15563.1 - 0.012 15.8 0.0 0.024 14.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain zf-CHC2 PF01807.20 ELR15563.1 - 0.025 14.4 0.2 0.05 13.4 0.2 1.4 1 0 0 1 1 1 0 CHC2 zinc finger AAA_29 PF13555.6 ELR15563.1 - 0.027 14.2 2.5 0.047 13.4 0.4 2.3 2 0 0 2 2 2 0 P-loop containing region of AAA domain T2SSE PF00437.20 ELR15563.1 - 0.029 13.4 0.0 0.045 12.8 0.0 1.2 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_18 PF13238.6 ELR15563.1 - 0.032 14.8 0.0 0.075 13.6 0.0 1.6 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 ELR15563.1 - 0.045 14.2 0.0 0.1 13.0 0.0 1.6 1 0 0 1 1 1 0 RNA helicase Toprim PF01751.22 ELR15563.1 - 0.072 13.3 0.0 0.99 9.7 0.0 2.6 2 1 0 2 2 2 0 Toprim domain CbiA PF01656.23 ELR15563.1 - 0.1 12.6 0.0 0.18 11.8 0.0 1.6 1 0 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain NACHT PF05729.12 ELR15563.1 - 0.12 12.2 0.1 0.27 11.2 0.1 1.5 1 0 0 1 1 1 0 NACHT domain cobW PF02492.19 ELR15563.1 - 0.13 11.9 0.1 0.25 10.9 0.1 1.5 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA_7 PF12775.7 ELR15563.1 - 0.13 11.7 0.1 0.31 10.5 0.1 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region IstB_IS21 PF01695.17 ELR15563.1 - 0.14 11.9 0.0 0.23 11.1 0.0 1.3 1 0 0 1 1 1 0 IstB-like ATP binding protein NTPase_1 PF03266.15 ELR15563.1 - 0.17 11.8 0.2 0.35 10.7 0.2 1.4 1 0 0 1 1 1 0 NTPase DUF3498 PF12004.8 ELR15565.1 - 2.7 7.1 16.3 3.2 6.8 16.3 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF3498) Adeno_terminal PF02459.15 ELR15565.1 - 8.9 4.6 8.3 10 4.4 8.3 1.0 1 0 0 1 1 1 0 Adenoviral DNA terminal protein Abhydrolase_3 PF07859.13 ELR15566.1 - 2e-32 112.8 0.4 3.6e-23 82.5 0.0 3.2 4 0 0 4 4 4 2 alpha/beta hydrolase fold Say1_Mug180 PF10340.9 ELR15566.1 - 1e-10 41.1 0.0 4.3e-10 39.0 0.0 1.8 2 0 0 2 2 2 1 Steryl acetyl hydrolase Peptidase_M50 PF02163.22 ELR15567.1 - 1.7e-18 66.8 0.0 5.5e-18 65.1 0.0 1.7 1 1 0 1 1 1 1 Peptidase family M50 Rieske PF00355.26 ELR15568.1 - 1.6e-13 50.4 0.1 3e-13 49.5 0.1 1.4 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain DUF3180 PF11377.8 ELR15568.1 - 0.0027 17.8 1.4 0.0042 17.2 1.4 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3180) Tail_VII PF17091.5 ELR15568.1 - 0.41 10.6 3.0 2.2 8.2 0.2 2.4 2 0 0 2 2 2 0 Inovirus G7P protein PTEN_C2 PF10409.9 ELR15569.1 - 3.3e-10 39.9 0.0 8.7e-09 35.2 0.0 2.8 1 1 0 1 1 1 1 C2 domain of PTEN tumour-suppressor protein SH3_1 PF00018.28 ELR15570.1 - 1.9e-58 193.9 5.2 1.9e-14 53.0 0.1 4.6 4 0 0 4 4 4 4 SH3 domain SH3_9 PF14604.6 ELR15570.1 - 3.4e-56 186.9 2.4 1.1e-15 57.2 0.0 4.6 4 0 0 4 4 4 4 Variant SH3 domain SH3_2 PF07653.17 ELR15570.1 - 3.3e-51 170.8 5.6 3.8e-14 52.1 0.1 4.4 4 0 0 4 4 4 4 Variant SH3 domain SH3_10 PF17902.1 ELR15570.1 - 6.8e-06 26.1 0.1 2.8 8.1 0.0 4.6 4 0 0 4 4 4 1 SH3 domain Neprosin PF03080.15 ELR15570.1 - 0.12 11.7 1.9 1.4 8.2 0.0 2.8 3 0 0 3 3 3 0 Neprosin DUF5348 PF17295.2 ELR15570.1 - 0.37 10.7 2.7 21 5.1 0.0 3.7 4 0 0 4 4 4 0 Domain of unknown function (DUF5348) Borrelia_P83 PF05262.11 ELR15570.1 - 4 5.8 35.4 54 2.1 36.0 2.1 2 0 0 2 2 2 0 Borrelia P83/100 protein RCC1 PF00415.18 ELR15571.1 - 5.5e-28 97.3 18.0 2.7e-13 50.3 0.2 7.7 7 1 0 7 7 7 5 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 ELR15571.1 - 4.3e-21 74.2 27.8 1.5e-07 31.0 0.2 7.2 8 0 0 8 8 8 4 Regulator of chromosome condensation (RCC1) repeat Hira PF07569.11 ELR15571.1 - 0.0041 16.9 0.1 8.2 6.1 0.0 3.4 3 1 1 4 4 4 2 TUP1-like enhancer of split Peptidase_C48 PF02902.19 ELR15572.1 - 5.2e-26 91.8 0.2 5.2e-26 91.8 0.2 2.0 3 0 0 3 3 3 1 Ulp1 protease family, C-terminal catalytic domain adh_short PF00106.25 ELR15573.1 - 9.1e-47 159.0 0.1 1.5e-46 158.3 0.1 1.3 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ELR15573.1 - 3.9e-33 115.0 0.2 7.7e-33 114.0 0.2 1.5 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ELR15573.1 - 3.2e-08 33.7 0.3 7.6e-08 32.5 0.3 1.6 1 1 0 1 1 1 1 KR domain NAD_binding_10 PF13460.6 ELR15573.1 - 4.7e-07 29.9 0.2 6.1e-07 29.5 0.2 1.2 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 ELR15573.1 - 0.0016 18.0 0.1 0.0037 16.8 0.1 1.6 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family DUF1776 PF08643.10 ELR15573.1 - 0.013 14.9 0.0 0.018 14.4 0.0 1.1 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) CoatB PF10389.9 ELR15573.1 - 0.4 10.6 4.5 1 9.2 4.5 1.7 1 0 0 1 1 1 0 Bacteriophage coat protein B 2OG-FeII_Oxy PF03171.20 ELR15574.1 - 2.4e-08 34.4 0.0 6.5e-08 33.0 0.0 1.7 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily U79_P34 PF03064.16 ELR15576.1 - 2.6 7.4 11.8 3.9 6.8 11.8 1.2 1 0 0 1 1 1 0 HSV U79 / HCMV P34 Presenilin PF01080.17 ELR15576.1 - 4.1 6.1 4.4 5 5.8 4.4 1.3 1 0 0 1 1 1 0 Presenilin RR_TM4-6 PF06459.12 ELR15576.1 - 6 6.6 11.0 0.26 11.1 5.6 1.5 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 Connexin PF00029.19 ELR15576.1 - 8.6 6.0 5.1 13 5.4 5.1 1.2 1 0 0 1 1 1 0 Connexin zf-CCCH_2 PF14608.6 ELR15577.1 - 1.5e-23 82.4 61.2 6.8e-05 23.2 6.3 6.2 6 0 0 6 6 6 6 RNA-binding, Nab2-type zinc finger PWI PF01480.17 ELR15577.1 - 0.008 16.5 0.1 0.017 15.4 0.1 1.4 1 0 0 1 1 1 1 PWI domain zf-CCCH PF00642.24 ELR15577.1 - 0.014 15.3 50.9 0.097 12.6 1.0 8.0 5 3 1 6 6 6 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Nab2p_Zf1 PF18260.1 ELR15577.1 - 0.014 15.3 1.5 0.014 15.3 1.5 3.1 3 0 0 3 3 3 0 Nuclear polyadenylated RNA-binding 2 protein CCCH zinc finger 1 zf-CCCH_4 PF18044.1 ELR15577.1 - 7.3 6.5 53.7 0.12 12.2 2.8 7.3 8 0 0 8 8 8 0 CCCH-type zinc finger Pkinase_Tyr PF07714.17 ELR15578.1 - 2.6e-118 394.0 0.0 9e-65 218.5 0.0 3.1 2 1 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 ELR15578.1 - 1.7e-105 352.2 0.0 5.6e-54 183.3 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Guanylate_cyc PF00211.20 ELR15578.1 - 2.5e-05 24.0 0.0 6e-05 22.7 0.0 1.5 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain Kinase-like PF14531.6 ELR15578.1 - 3e-05 23.5 0.0 0.17 11.2 0.0 2.3 2 0 0 2 2 2 2 Kinase-like ABC1 PF03109.16 ELR15578.1 - 4.6e-05 23.6 0.0 0.045 13.9 0.0 3.4 3 0 0 3 3 3 1 ABC1 family EGF_2 PF07974.13 ELR15578.1 - 0.00014 22.2 12.4 0.00027 21.3 12.4 1.5 1 0 0 1 1 1 1 EGF-like domain Haspin_kinase PF12330.8 ELR15578.1 - 0.00039 19.5 0.0 0.19 10.6 0.0 3.0 2 1 0 2 2 2 1 Haspin like kinase domain APH PF01636.23 ELR15578.1 - 0.00063 19.7 0.9 0.24 11.3 0.1 2.8 2 1 0 2 2 2 1 Phosphotransferase enzyme family EGF PF00008.27 ELR15578.1 - 0.0031 17.8 5.4 0.0063 16.8 5.4 1.6 1 0 0 1 1 1 1 EGF-like domain DUF3844 PF12955.7 ELR15578.1 - 0.0084 16.2 0.6 0.025 14.7 0.6 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF3844) Kdo PF06293.14 ELR15578.1 - 0.016 14.6 0.0 0.75 9.1 0.0 2.3 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family hEGF PF12661.7 ELR15578.1 - 0.017 15.7 4.3 0.059 14.0 4.3 2.0 1 0 0 1 1 1 0 Human growth factor-like EGF Plasmod_Pvs28 PF06247.11 ELR15578.1 - 0.032 14.5 1.8 0.065 13.5 1.8 1.4 1 0 0 1 1 1 0 Pvs28 EGF domain RIO1 PF01163.22 ELR15578.1 - 0.18 11.3 0.6 2.1 7.9 0.5 2.4 2 1 0 2 2 2 0 RIO1 family EGF_CA PF07645.15 ELR15578.1 - 4.2 7.7 6.9 8.7 6.6 6.9 1.5 1 0 0 1 1 1 0 Calcium-binding EGF domain EGF_3 PF12947.7 ELR15578.1 - 4.5 7.6 7.9 9.7 6.5 7.9 1.6 1 0 0 1 1 1 0 EGF domain COesterase PF00135.28 ELR15579.1 - 4e-112 375.7 0.0 5.1e-112 375.4 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 ELR15579.1 - 7.7e-09 35.7 0.5 2.4e-08 34.1 0.5 1.9 1 1 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 ELR15579.1 - 0.0056 16.2 0.0 0.014 14.9 0.0 1.6 1 0 0 1 1 1 1 Prolyl oligopeptidase family Say1_Mug180 PF10340.9 ELR15579.1 - 0.14 10.9 0.2 0.88 8.4 0.2 1.9 1 1 0 1 1 1 0 Steryl acetyl hydrolase SH3_1 PF00018.28 ELR15580.1 - 2.3e-15 55.9 0.4 4.2e-15 55.1 0.4 1.4 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 ELR15580.1 - 2.7e-13 49.5 1.0 4.8e-13 48.8 1.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 ELR15580.1 - 1.2e-12 47.3 0.1 2.1e-12 46.5 0.1 1.4 1 0 0 1 1 1 1 Variant SH3 domain Glutaminase PF04960.15 ELR15580.1 - 0.25 10.5 3.6 0.39 9.9 3.6 1.2 1 0 0 1 1 1 0 Glutaminase DUF3584 PF12128.8 ELR15580.1 - 7.2 4.0 42.8 13 3.2 42.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) LRR_4 PF12799.7 ELR15581.1 - 2.3e-17 62.8 21.6 5.8e-05 23.4 0.0 5.7 3 1 1 5 5 5 5 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 ELR15581.1 - 1.4e-14 53.5 19.6 1.1e-07 31.5 1.2 3.5 2 1 1 3 3 3 3 Leucine rich repeat LRR_1 PF00560.33 ELR15581.1 - 0.00096 19.4 19.9 0.63 10.8 0.3 7.4 6 2 0 6 6 6 1 Leucine Rich Repeat LRR_6 PF13516.6 ELR15581.1 - 0.28 11.4 14.4 1 9.6 0.1 6.0 6 0 0 6 6 6 0 Leucine Rich repeat PAS_12 PF18095.1 ELR15582.1 - 0.16 11.6 0.0 0.17 11.5 0.0 1.1 1 0 0 1 1 1 0 UPF0242 C-terminal PAS-like domain RRM_1 PF00076.22 ELR15584.1 - 3.8e-42 142.0 0.0 9.5e-21 73.4 0.0 2.1 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 ELR15584.1 - 9.4e-06 25.6 0.0 0.18 11.8 0.0 2.2 2 0 0 2 2 2 2 RNA binding motif Limkain-b1 PF11608.8 ELR15584.1 - 0.0031 17.5 0.0 0.98 9.5 0.0 2.5 2 2 0 2 2 2 1 Limkain b1 Myb_DNA-bind_2 PF08914.11 ELR15584.1 - 0.024 14.8 0.3 1.3 9.3 0.0 2.3 2 0 0 2 2 2 0 Rap1 Myb domain SPOR PF05036.13 ELR15584.1 - 0.058 13.8 0.0 4.7 7.7 0.0 2.8 2 1 1 3 3 3 0 Sporulation related domain DUF448 PF04296.13 ELR15584.1 - 0.074 12.9 0.0 8.3 6.4 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF448) ATP-grasp_2 PF08442.10 ELR15584.1 - 0.11 12.1 0.0 3.7 7.1 0.0 2.1 2 0 0 2 2 2 0 ATP-grasp domain Nup35_RRM_2 PF14605.6 ELR15584.1 - 0.14 12.1 0.0 9.3 6.3 0.0 2.4 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif RRM_7 PF16367.5 ELR15584.1 - 0.18 11.9 0.0 18 5.5 0.0 2.4 2 0 0 2 2 2 0 RNA recognition motif RQC PF09382.10 ELR15585.1 - 3.6e-20 71.9 0.2 1.1e-19 70.2 0.0 1.9 2 0 0 2 2 2 1 RQC domain RecQ_Zn_bind PF16124.5 ELR15585.1 - 4e-15 56.3 6.5 4e-15 56.3 6.5 3.1 4 0 0 4 4 4 1 RecQ zinc-binding Helicase_C PF00271.31 ELR15585.1 - 4.2e-14 52.8 0.1 4.5e-13 49.5 0.0 2.5 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 ELR15585.1 - 0.03 14.1 0.0 0.1 12.3 0.0 1.9 2 0 0 2 2 2 0 DEAD/DEAH box helicase DSPc PF00782.20 ELR15586.1 - 0.0042 16.9 0.0 0.0064 16.3 0.0 1.3 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Ank_4 PF13637.6 ELR15588.1 - 1.2e-15 57.7 1.6 1.9e-08 34.7 0.1 3.4 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 ELR15588.1 - 9.8e-14 51.7 0.5 1.2e-12 48.2 0.4 2.2 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 ELR15588.1 - 1.9e-11 44.0 0.1 6.4e-07 29.5 0.0 2.5 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 ELR15588.1 - 4.3e-11 42.7 3.4 0.00018 21.8 0.0 3.8 4 1 0 4 4 4 2 Ankyrin repeat Ank_3 PF13606.6 ELR15588.1 - 4.7e-09 35.8 0.1 0.00023 21.4 0.0 3.8 4 0 0 4 4 4 2 Ankyrin repeat GATase PF00117.28 ELR15589.1 - 1.4e-31 109.8 0.0 2.5e-31 108.9 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase class-I GMP_synt_C PF00958.22 ELR15589.1 - 9e-22 76.9 0.0 1.6e-11 44.1 0.0 2.7 2 0 0 2 2 2 2 GMP synthase C terminal domain Peptidase_C26 PF07722.13 ELR15589.1 - 1.3e-09 38.1 0.0 3.5e-09 36.7 0.0 1.8 1 0 0 1 1 1 1 Peptidase C26 NAD_synthase PF02540.17 ELR15589.1 - 5.9e-06 25.6 0.0 0.0021 17.2 0.0 2.5 2 0 0 2 2 2 2 NAD synthase ATP_bind_3 PF01171.20 ELR15589.1 - 3.9e-05 23.5 0.1 0.00015 21.5 0.0 1.9 2 0 0 2 2 2 1 PP-loop family Asn_synthase PF00733.21 ELR15589.1 - 0.00067 19.4 0.1 0.0011 18.7 0.1 1.3 1 0 0 1 1 1 1 Asparagine synthase QueC PF06508.13 ELR15589.1 - 0.0011 18.5 0.0 0.0038 16.8 0.0 1.8 2 0 0 2 2 2 1 Queuosine biosynthesis protein QueC tRNA_Me_trans PF03054.16 ELR15589.1 - 0.014 14.2 0.1 0.025 13.4 0.1 1.4 1 0 0 1 1 1 0 tRNA methyl transferase PAPS_reduct PF01507.19 ELR15589.1 - 0.014 15.4 0.0 0.025 14.6 0.0 1.3 1 0 0 1 1 1 0 Phosphoadenosine phosphosulfate reductase family ThiI PF02568.14 ELR15589.1 - 0.054 13.1 0.0 0.099 12.2 0.0 1.4 1 0 0 1 1 1 0 Thiamine biosynthesis protein (ThiI) Ribosomal_L23eN PF03939.13 ELR15590.1 - 2.6e-16 59.6 9.8 2.6e-16 59.6 9.8 3.7 2 1 1 3 3 3 1 Ribosomal protein L23, N-terminal domain Ribosomal_L23 PF00276.20 ELR15590.1 - 1.4e-15 57.4 2.1 1.4e-15 57.4 2.1 2.6 2 2 0 2 2 2 1 Ribosomal protein L23 ASL_C PF08328.11 ELR15590.1 - 0.012 15.7 0.0 0.028 14.5 0.0 1.5 1 0 0 1 1 1 0 Adenylosuccinate lyase C-terminal DNA_Packaging PF11053.8 ELR15590.1 - 0.076 12.9 2.3 0.27 11.1 0.1 2.3 2 0 0 2 2 2 0 Terminase DNA packaging enzyme NPR3 PF03666.13 ELR15590.1 - 0.11 11.2 4.3 0.14 10.9 4.3 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 APG9 PF04109.16 ELR15591.1 - 1.9e-140 469.1 9.6 2.5e-140 468.7 9.6 1.1 1 0 0 1 1 1 1 Autophagy protein Apg9 Methyltransf_11 PF08241.12 ELR15592.1 - 9.5e-18 64.6 0.0 1.7e-17 63.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ELR15592.1 - 8.4e-17 61.7 0.0 1.8e-16 60.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 ELR15592.1 - 4.6e-12 46.1 0.0 6e-12 45.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ELR15592.1 - 7.1e-12 45.4 0.0 1e-11 44.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ELR15592.1 - 4e-09 37.1 0.0 7e-09 36.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 ELR15592.1 - 2.5e-06 27.0 0.0 3.9e-06 26.4 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_2 PF00891.18 ELR15592.1 - 0.12 11.6 0.0 0.19 11.0 0.0 1.4 1 0 0 1 1 1 0 O-methyltransferase domain Pro_CA PF00484.19 ELR15594.1 - 6.1e-48 163.0 0.3 9.6e-48 162.4 0.3 1.3 1 0 0 1 1 1 1 Carbonic anhydrase DNA_pol_phi PF04931.13 ELR15595.1 - 9 4.3 6.3 18 3.3 6.3 1.4 1 0 0 1 1 1 0 DNA polymerase phi FAM176 PF14851.6 ELR15595.1 - 9.3 5.9 7.2 1.7 8.3 3.1 1.8 2 0 0 2 2 2 0 FAM176 family Zn_clus PF00172.18 ELR15596.1 - 0.00012 22.1 9.4 0.00025 21.1 9.4 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain PAS_9 PF13426.7 ELR15596.1 - 0.026 14.8 0.0 0.059 13.6 0.0 1.5 1 0 0 1 1 1 0 PAS domain Zip PF02535.22 ELR15596.1 - 0.083 12.1 0.6 0.12 11.6 0.6 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter Tmemb_cc2 PF10267.9 ELR15596.1 - 4 6.5 12.9 0.32 10.1 7.2 1.8 2 0 0 2 2 2 0 Predicted transmembrane and coiled-coil 2 protein AT_hook PF02178.19 ELR15596.1 - 5.4 7.2 8.8 19 5.6 8.8 1.9 1 0 0 1 1 1 0 AT hook motif UCH PF00443.29 ELR15597.1 - 4.4e-45 154.2 3.1 8.7e-45 153.2 0.5 2.9 4 0 0 4 4 4 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 ELR15597.1 - 5.2e-33 115.0 0.7 1.5e-32 113.5 0.7 1.8 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase ubiquitin PF00240.23 ELR15597.1 - 5.3e-09 35.7 0.0 1.4e-08 34.3 0.0 1.8 1 0 0 1 1 1 1 Ubiquitin family Ras PF00071.22 ELR15598.1 - 1.9e-63 212.9 0.3 2.1e-63 212.7 0.3 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR15598.1 - 3e-34 117.8 0.0 5.1e-34 117.1 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR15598.1 - 6.2e-14 51.8 0.0 7.9e-14 51.5 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 ELR15598.1 - 1.1e-05 25.5 0.0 1.8e-05 24.8 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 ELR15598.1 - 5.8e-05 22.6 0.0 6.8e-05 22.3 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 ELR15598.1 - 0.00033 20.2 0.0 0.0011 18.5 0.0 1.8 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 ELR15598.1 - 0.0017 18.3 0.2 1.7 8.6 0.0 2.4 1 1 2 3 3 3 2 RsgA GTPase SRPRB PF09439.10 ELR15598.1 - 0.0054 16.2 0.1 0.0083 15.6 0.1 1.3 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit PRELI PF04707.14 ELR15599.1 - 4.1e-33 114.4 0.0 4.9e-33 114.2 0.0 1.1 1 0 0 1 1 1 1 PRELI-like family Mucin PF01456.17 ELR15600.1 - 6.7e-05 22.9 20.2 0.00053 20.0 18.0 2.3 2 0 0 2 2 2 1 Mucin-like glycoprotein Molydop_binding PF01568.21 ELR15600.1 - 0.0097 15.9 0.0 0.02 14.9 0.0 1.4 1 0 0 1 1 1 1 Molydopterin dinucleotide binding domain Bactofilin PF04519.13 ELR15600.1 - 0.036 14.4 0.8 1.4 9.2 0.6 2.7 2 0 0 2 2 2 0 Polymer-forming cytoskeletal Glyco_transf_54 PF04666.13 ELR15602.1 - 5e-12 45.3 0.0 0.001 18.0 0.0 3.0 3 0 0 3 3 3 3 N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region DUF4148 PF13663.6 ELR15602.1 - 1.1 9.5 5.7 11 6.3 0.0 3.6 4 0 0 4 4 4 0 Domain of unknown function (DUF4148) dCMP_cyt_deam_1 PF00383.23 ELR15603.1 - 1.6e-20 72.9 0.0 7.6e-15 54.6 0.0 2.2 2 0 0 2 2 2 2 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 ELR15603.1 - 1.1e-15 57.6 0.8 5.3e-12 45.7 0.8 3.0 1 1 0 1 1 1 1 MafB19-like deaminase Bd3614-deam PF14439.6 ELR15603.1 - 0.00025 21.1 0.2 0.00053 20.1 0.2 1.6 1 1 0 1 1 1 1 Bd3614-like deaminase Ras PF00071.22 ELR15604.1 - 4.8e-43 146.6 0.0 8.2e-43 145.8 0.0 1.4 1 1 0 1 1 1 1 Ras family Roc PF08477.13 ELR15604.1 - 1.9e-22 79.7 0.0 3e-22 79.1 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR15604.1 - 1e-08 34.8 0.0 3.4e-08 33.1 0.0 1.7 1 1 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 ELR15604.1 - 0.063 13.2 0.0 0.11 12.4 0.0 1.4 2 0 0 2 2 2 0 RsgA GTPase SKA1 PF07160.12 ELR15605.1 - 3.1e-37 128.7 0.3 3.8e-37 128.4 0.3 1.0 1 0 0 1 1 1 1 Spindle and kinetochore-associated protein 1 Transcrip_act PF04949.13 ELR15605.1 - 0.051 13.5 1.2 0.25 11.2 0.6 2.0 2 0 0 2 2 2 0 Transcriptional activator Herpes_U30 PF04523.13 ELR15605.1 - 0.07 11.0 0.9 0.081 10.8 0.2 1.4 2 0 0 2 2 2 0 Herpes virus tegument protein U30 DUF3450 PF11932.8 ELR15605.1 - 0.21 10.8 5.1 0.038 13.3 1.2 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) Noelin-1 PF12308.8 ELR15605.1 - 0.38 10.8 3.6 0.39 10.7 1.2 2.2 2 1 1 3 3 3 0 Neurogenesis glycoprotein 2OG-FeII_Oxy_2 PF13532.6 ELR15606.1 - 5.7e-12 46.2 0.0 6.3e-12 46.1 0.0 1.0 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Acetyltransf_1 PF00583.25 ELR15607.1 - 4.8e-16 59.0 0.0 6e-16 58.7 0.0 1.3 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 ELR15607.1 - 1.7e-11 44.4 0.0 2.3e-11 44.0 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 ELR15607.1 - 7.5e-09 35.6 0.0 1.1e-08 35.1 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 ELR15607.1 - 1.4e-05 25.1 0.0 2.8e-05 24.1 0.0 1.4 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase FR47 PF08445.10 ELR15607.1 - 0.0013 18.7 0.0 0.0024 17.8 0.0 1.4 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_3 PF13302.7 ELR15607.1 - 0.0043 17.7 0.0 0.0054 17.4 0.0 1.3 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 ELR15607.1 - 0.014 15.4 0.0 0.022 14.9 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 ELR15607.1 - 0.11 12.6 0.0 0.17 12.0 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Bromodomain PF00439.25 ELR15608.1 - 1.9e-20 72.7 0.1 3.4e-20 71.9 0.1 1.4 1 0 0 1 1 1 1 Bromodomain SNAPc19 PF15497.6 ELR15608.1 - 0.0068 16.8 3.3 0.0068 16.8 3.3 3.3 2 0 0 2 2 2 1 snRNA-activating protein complex subunit 19, SNAPc subunit 19 DUF563 PF04577.14 ELR15609.1 - 1.5e-16 61.2 0.3 2.8e-16 60.3 0.3 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF563) DJ-1_PfpI PF01965.24 ELR15610.1 - 2.3e-37 128.3 0.1 7.2e-37 126.7 0.1 1.6 1 1 0 1 1 1 1 DJ-1/PfpI family SKIP_SNW PF02731.15 ELR15611.1 - 2.6e-69 232.0 0.9 2.6e-69 232.0 0.9 2.0 2 0 0 2 2 2 1 SKIP/SNW domain GSH_synth_ATP PF03917.17 ELR15612.1 - 3.4e-112 374.9 0.0 7.1e-111 370.6 0.0 1.9 1 1 1 2 2 2 2 Eukaryotic glutathione synthase, ATP binding domain GSH_synthase PF03199.15 ELR15612.1 - 2.1e-29 102.0 0.1 1.3e-28 99.5 0.1 2.2 1 1 0 1 1 1 1 Eukaryotic glutathione synthase DUF4552 PF15089.6 ELR15613.1 - 5.6 5.9 13.5 11 4.9 13.5 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4552) Stn1 PF10451.9 ELR15614.1 - 0.0045 16.0 0.0 0.0066 15.4 0.0 1.1 1 0 0 1 1 1 1 Telomere regulation protein Stn1 tRNA_anti-codon PF01336.25 ELR15614.1 - 0.013 15.5 0.0 0.021 14.8 0.0 1.3 1 0 0 1 1 1 0 OB-fold nucleic acid binding domain MYEOV2 PF15004.6 ELR15615.1 - 0.0016 18.8 12.0 0.002 18.5 12.0 1.3 1 0 0 1 1 1 1 Myeloma-overexpressed-like IU_nuc_hydro PF01156.19 ELR15615.1 - 0.0022 17.6 0.9 0.0025 17.5 0.9 1.1 1 0 0 1 1 1 1 Inosine-uridine preferring nucleoside hydrolase Rtt106 PF08512.12 ELR15616.1 - 1.1e-28 99.5 0.1 1.7e-25 89.3 0.0 2.8 3 0 0 3 3 3 2 Histone chaperone Rttp106-like SSrecog PF03531.14 ELR15616.1 - 9e-24 83.2 0.0 2.1e-23 82.0 0.0 1.7 1 0 0 1 1 1 1 Structure-specific recognition protein (SSRP1) POB3_N PF17292.2 ELR15616.1 - 1.7e-22 79.7 3.0 5.2e-19 68.5 0.5 2.7 2 1 0 2 2 2 2 POB3-like N-terminal PH domain Cyclin_N PF00134.23 ELR15617.1 - 5.4e-45 152.2 1.2 6.6e-41 139.0 0.1 2.3 2 0 0 2 2 2 2 Cyclin, N-terminal domain Cyclin_C PF02984.19 ELR15617.1 - 6.2e-34 116.6 0.3 1.7e-33 115.2 0.3 1.8 1 0 0 1 1 1 1 Cyclin, C-terminal domain AFG1_ATPase PF03969.16 ELR15617.1 - 0.042 12.7 1.0 0.076 11.9 1.0 1.3 1 0 0 1 1 1 0 AFG1-like ATPase Nop25 PF09805.9 ELR15617.1 - 1.6 9.2 12.0 0.17 12.4 5.0 2.3 2 0 0 2 2 2 0 Nucleolar protein 12 (25kDa) Cwf_Cwc_15 PF04889.12 ELR15617.1 - 8.5 6.0 18.0 3.6 7.3 7.5 2.3 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein DUF5483 PF17581.2 ELR15620.1 - 0.19 10.6 0.0 0.2 10.5 0.0 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5483) Ank_2 PF12796.7 ELR15622.1 - 1.6e-20 73.5 7.4 3.3e-08 34.0 0.0 4.2 3 1 1 4 4 4 3 Ankyrin repeats (3 copies) Ank_5 PF13857.6 ELR15622.1 - 2e-19 69.4 10.3 9.8e-08 32.1 0.8 4.3 4 0 0 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 ELR15622.1 - 6e-19 66.2 6.0 2.5e-06 27.4 0.1 5.6 5 0 0 5 5 5 3 Ankyrin repeat Ank_4 PF13637.6 ELR15622.1 - 7.8e-18 64.6 4.5 2.6e-06 27.8 0.4 4.5 2 1 2 4 4 4 4 Ankyrin repeats (many copies) Ank PF00023.30 ELR15622.1 - 1.6e-15 56.7 16.4 1.3e-05 25.4 0.8 4.8 4 0 0 4 4 4 4 Ankyrin repeat PH PF00169.29 ELR15622.1 - 7.8e-10 39.2 0.1 1.8e-09 38.1 0.1 1.6 1 0 0 1 1 1 1 PH domain RhoGAP PF00620.27 ELR15622.1 - 1.7e-09 37.7 0.2 3.4e-09 36.7 0.2 1.5 1 0 0 1 1 1 1 RhoGAP domain LIM PF00412.22 ELR15622.1 - 1e-08 35.3 13.4 0.00011 22.3 4.6 2.4 2 0 0 2 2 2 2 LIM domain PH_11 PF15413.6 ELR15622.1 - 0.0042 17.5 0.1 0.01 16.3 0.1 1.7 1 0 0 1 1 1 1 Pleckstrin homology domain H_lectin PF09458.10 ELR15623.1 - 1e-41 141.0 6.4 3.6e-15 55.9 0.1 3.3 3 0 0 3 3 3 3 H-type lectin domain zf-C3HC4_3 PF13920.6 ELR15623.1 - 4.1e-14 52.2 9.9 6.4e-14 51.6 9.9 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 ELR15623.1 - 1.4e-08 34.5 9.1 2.4e-08 33.7 9.1 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_2 PF13639.6 ELR15623.1 - 0.0001 22.6 9.8 0.0002 21.6 9.8 1.5 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.6 ELR15623.1 - 0.0004 20.3 10.5 0.00078 19.3 10.5 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4 PF00097.25 ELR15623.1 - 0.0011 18.8 10.6 0.0018 18.1 10.6 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 ELR15623.1 - 0.016 15.0 10.5 0.031 14.1 10.5 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 ELR15623.1 - 0.05 13.6 5.9 0.034 14.2 3.5 2.0 1 1 1 2 2 2 0 RING-type zinc-finger Sde2_N_Ubi PF13019.6 ELR15624.1 - 0.18 11.6 0.0 0.24 11.2 0.0 1.2 1 0 0 1 1 1 0 Silencing defective 2 N-terminal ubiquitin domain Ribosomal_60s PF00428.19 ELR15626.1 - 0.93 10.1 10.6 0.14 12.8 4.7 2.1 2 0 0 2 2 2 0 60s Acidic ribosomal protein Aa_trans PF01490.18 ELR15627.1 - 9.9e-72 241.9 21.3 3.1e-62 210.6 10.3 2.0 1 1 1 2 2 2 2 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.13 ELR15627.1 - 1.2e-14 54.2 12.0 1.2e-14 54.2 12.0 1.8 2 0 0 2 2 2 1 Tryptophan/tyrosine permease family AA_permease_2 PF13520.6 ELR15627.1 - 1e-08 34.5 11.6 1e-08 34.5 11.6 2.0 2 0 0 2 2 2 2 Amino acid permease Cullin_binding PF03556.15 ELR15628.1 - 2.1e-24 86.2 7.7 3.9e-24 85.4 7.7 1.4 1 0 0 1 1 1 1 Cullin binding SPRY PF00622.28 ELR15628.1 - 9.3e-23 80.6 0.1 1.5e-22 79.9 0.1 1.4 1 0 0 1 1 1 1 SPRY domain Laminin_G_3 PF13385.6 ELR15628.1 - 0.26 11.4 0.1 0.26 11.4 0.1 2.6 3 0 0 3 3 3 0 Concanavalin A-like lectin/glucanases superfamily DUF5349 PF17298.2 ELR15629.1 - 5.7 6.6 16.9 3.8 7.2 7.8 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF5349) Dna2 PF08696.11 ELR15630.1 - 3.9e-59 199.9 0.0 1.2e-58 198.2 0.1 1.8 2 0 0 2 2 2 1 DNA replication factor Dna2 AAA_12 PF13087.6 ELR15630.1 - 8.1e-52 175.7 0.0 1.7e-51 174.7 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 ELR15630.1 - 6.2e-22 78.6 0.0 1.4e-17 64.4 0.0 2.8 2 1 0 2 2 2 2 AAA domain Cas_Cas4 PF01930.17 ELR15630.1 - 2.8e-09 37.3 0.0 5.9e-08 33.0 0.0 2.4 2 0 0 2 2 2 1 Domain of unknown function DUF83 Viral_helicase1 PF01443.18 ELR15630.1 - 0.0005 19.9 0.0 1 9.1 0.0 2.5 2 0 0 2 2 2 2 Viral (Superfamily 1) RNA helicase UvrD_C_2 PF13538.6 ELR15630.1 - 0.015 15.1 0.0 0.037 13.9 0.0 1.6 1 0 0 1 1 1 0 UvrD-like helicase C-terminal domain AAA_30 PF13604.6 ELR15630.1 - 0.087 12.5 0.0 0.27 10.9 0.0 1.8 1 1 0 1 1 1 0 AAA domain SAD_SRA PF02182.17 ELR15631.1 - 1.4e-52 177.6 0.1 2.9e-52 176.5 0.1 1.6 1 0 0 1 1 1 1 SAD/SRA domain Metallophos PF00149.28 ELR15631.1 - 2.2e-18 67.5 0.1 4e-18 66.6 0.1 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase GATA PF00320.27 ELR15631.1 - 6.7e-08 32.0 9.7 1.9e-07 30.5 9.7 1.9 1 0 0 1 1 1 1 GATA zinc finger F-box-like PF12937.7 ELR15631.1 - 4e-06 26.6 0.0 7.7e-06 25.7 0.0 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ELR15631.1 - 0.0045 16.8 0.0 0.0086 15.9 0.0 1.5 1 0 0 1 1 1 1 F-box domain PB1 PF00564.24 ELR15632.1 - 1.5e-10 40.9 0.4 3.3e-10 39.8 0.4 1.6 1 0 0 1 1 1 1 PB1 domain Tmp39 PF10271.9 ELR15633.1 - 6.5e-30 104.5 16.1 8.1e-22 77.8 0.0 2.5 1 1 1 2 2 2 2 Putative transmembrane protein Acetyltransf_1 PF00583.25 ELR15634.1 - 0.0001 22.5 0.0 0.00021 21.5 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 ELR15634.1 - 0.00077 19.8 0.0 0.018 15.5 0.0 2.3 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 ELR15634.1 - 0.001 19.0 0.0 0.0025 17.8 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain ACOX PF01756.19 ELR15635.1 - 3.4e-43 147.3 0.0 6.9e-43 146.3 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA oxidase Acyl-CoA_ox_N PF14749.6 ELR15635.1 - 2.7e-19 69.9 0.3 5.1e-19 69.1 0.3 1.4 1 0 0 1 1 1 1 Acyl-coenzyme A oxidase N-terminal Acyl-CoA_dh_M PF02770.19 ELR15635.1 - 1.4e-11 44.4 0.0 2.6e-11 43.6 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain CarbopepD_reg_2 PF13715.6 ELR15635.1 - 0.068 13.2 0.0 0.31 11.1 0.0 2.0 2 0 0 2 2 2 0 CarboxypepD_reg-like domain PSI PF01437.25 ELR15636.1 - 1.6e-13 51.0 84.1 0.0026 18.2 11.4 5.5 4 1 1 5 5 5 5 Plexin repeat Neisseria_TspB PF05616.13 ELR15636.1 - 0.18 10.3 3.7 0.27 9.7 3.7 1.3 1 0 0 1 1 1 0 Neisseria meningitidis TspB protein Vinculin PF01044.19 ELR15637.1 - 2.8e-13 49.1 85.9 5.6e-08 31.5 7.4 6.2 3 2 3 6 6 6 6 Vinculin family DUF2959 PF11172.8 ELR15637.1 - 0.0052 16.9 0.9 0.0052 16.9 0.9 3.3 2 1 1 3 3 3 1 Protein of unknown function (DUF2959) TFIID_20kDa PF03847.13 ELR15637.1 - 0.12 12.9 0.1 0.48 11.0 0.1 2.1 1 0 0 1 1 1 0 Transcription initiation factor TFIID subunit A Syntaxin_2 PF14523.6 ELR15637.1 - 2.9 8.3 10.2 4.8 7.6 1.8 4.4 3 1 1 4 4 4 0 Syntaxin-like protein Ribosomal_L1 PF00687.21 ELR15638.1 - 3.9e-17 62.7 0.0 4.8e-17 62.4 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family F-box-like PF12937.7 ELR15638.1 - 2.4e-06 27.4 3.7 2.4e-06 27.4 3.7 2.0 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 ELR15638.1 - 0.018 14.9 1.5 0.05 13.5 1.5 1.8 1 0 0 1 1 1 0 F-box domain F-box_4 PF15966.5 ELR15638.1 - 0.061 13.2 0.4 0.18 11.7 0.4 1.8 1 0 0 1 1 1 0 F-box DUF4138 PF13595.6 ELR15638.1 - 0.23 10.7 0.0 2.2 7.5 0.0 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4138) Rad10 PF03834.14 ELR15639.1 - 5.6e-42 142.4 0.0 8.5e-42 141.8 0.0 1.3 1 0 0 1 1 1 1 Binding domain of DNA repair protein Ercc1 (rad10/Swi10) HHH_5 PF14520.6 ELR15639.1 - 1.3e-05 25.7 0.0 2.5e-05 24.8 0.0 1.4 1 0 0 1 1 1 1 Helix-hairpin-helix domain HHH PF00633.23 ELR15639.1 - 0.013 15.3 0.0 0.031 14.2 0.0 1.6 1 0 0 1 1 1 0 Helix-hairpin-helix motif HHH_2 PF12826.7 ELR15639.1 - 0.019 15.1 0.0 0.035 14.2 0.0 1.4 1 0 0 1 1 1 0 Helix-hairpin-helix motif Muted PF14942.6 ELR15641.1 - 0.0018 18.6 6.0 0.0018 18.6 6.0 3.9 4 0 0 4 4 4 1 Organelle biogenesis, Muted-like protein IpaB_EvcA PF03278.13 ELR15641.1 - 0.052 13.3 0.1 0.13 12.0 0.1 1.7 1 0 0 1 1 1 0 IpaB/EvcA family Polyoma_agno PF01736.16 ELR15641.1 - 0.082 12.6 0.4 0.3 10.9 0.4 2.0 1 0 0 1 1 1 0 Polyomavirus agnoprotein DUF3568 PF12092.8 ELR15641.1 - 0.36 10.9 4.9 4.3 7.4 0.2 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF3568) ERO1 PF04137.15 ELR15641.1 - 1.6 7.8 4.9 0.89 8.7 2.2 1.9 2 0 0 2 2 2 0 Endoplasmic Reticulum Oxidoreductin 1 (ERO1) Imm17 PF15562.6 ELR15642.1 - 0.058 13.3 0.1 0.09 12.7 0.1 1.3 1 0 0 1 1 1 0 Immunity protein 17 GATA PF00320.27 ELR15644.1 - 2.2e-05 23.9 4.2 3.4e-05 23.3 4.2 1.3 1 0 0 1 1 1 1 GATA zinc finger Ofd1_CTDD PF10637.9 ELR15645.1 - 2.7e-46 158.0 0.1 5.2e-37 127.6 0.0 3.3 2 1 0 2 2 2 2 Oxoglutarate and iron-dependent oxygenase degradation C-term 2OG-FeII_Oxy_4 PF13661.6 ELR15645.1 - 8.2e-31 106.5 0.0 1e-28 99.8 0.0 2.4 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_3 PF13640.6 ELR15645.1 - 1.2e-16 61.3 0.0 8.9e-15 55.4 0.0 2.3 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily Peptidase_C78 PF07910.13 ELR15646.1 - 8.4e-39 133.2 0.0 1.9e-38 132.1 0.0 1.6 1 1 0 1 1 1 1 Peptidase family C78 CBM49 PF09478.10 ELR15647.1 - 6.6e-15 55.2 0.4 1e-14 54.5 0.4 1.3 1 1 0 1 1 1 1 Carbohydrate binding domain CBM49 CBM_2 PF00553.19 ELR15647.1 - 0.01 16.1 0.8 0.02 15.2 0.6 1.5 1 1 0 1 1 1 0 Cellulose binding domain DUF2393 PF09624.10 ELR15647.1 - 0.05 13.6 0.0 0.2 11.6 0.0 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF2393) TMEM132D_C PF15706.5 ELR15647.1 - 0.069 12.9 0.1 0.12 12.2 0.1 1.4 1 0 0 1 1 1 0 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term AA_permease_2 PF13520.6 ELR15648.1 - 9.5e-31 107.1 20.8 9.5e-31 107.1 20.8 1.5 1 1 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 ELR15648.1 - 1.4e-22 79.9 18.8 2.8e-22 79.0 18.7 1.6 1 1 0 1 1 1 1 Amino acid permease AA_permease_C PF13906.6 ELR15648.1 - 3.9e-20 71.7 2.8 2e-19 69.4 2.8 2.4 1 0 0 1 1 1 1 C-terminus of AA_permease Ac76 PF05814.11 ELR15648.1 - 0.36 10.9 2.7 0.92 9.6 0.0 2.5 2 0 0 2 2 2 0 Orf76 (Ac76) Pkinase_Tyr PF07714.17 ELR15649.1 - 2.4e-27 95.9 0.0 2.1e-26 92.8 0.0 2.1 1 1 1 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.25 ELR15649.1 - 4.4e-26 91.8 0.4 7.7e-26 91.0 0.4 1.5 1 0 0 1 1 1 1 Protein kinase domain Kinase-like PF14531.6 ELR15649.1 - 0.00066 19.1 0.0 0.0012 18.2 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Plasmodium_Vir PF05795.11 ELR15649.1 - 0.049 13.0 7.5 0.084 12.3 7.5 1.3 1 0 0 1 1 1 0 Plasmodium vivax Vir protein DUF5083 PF16890.5 ELR15649.1 - 0.15 11.8 11.1 0.19 11.5 0.3 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF5083) Macoilin PF09726.9 ELR15649.1 - 0.31 9.6 13.3 0.45 9.0 13.3 1.1 1 0 0 1 1 1 0 Macoilin family Colicin_V PF02674.16 ELR15649.1 - 0.41 10.6 8.5 0.3 11.0 6.9 1.6 1 1 0 1 1 1 0 Colicin V production protein PNISR PF15996.5 ELR15649.1 - 1.5 9.0 21.3 2.5 8.3 21.3 1.3 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR DUF3336 PF11815.8 ELR15650.1 - 5.5e-29 100.7 1.3 1.2e-28 99.5 0.8 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF3336) Patatin PF01734.22 ELR15650.1 - 9.8e-24 84.7 0.0 1.7e-23 83.9 0.0 1.3 1 0 0 1 1 1 1 Patatin-like phospholipase Peptidase_S51 PF03575.17 ELR15650.1 - 0.097 12.3 0.0 0.19 11.4 0.0 1.4 1 0 0 1 1 1 0 Peptidase family S51 CBM49 PF09478.10 ELR15653.1 - 2.3e-25 88.7 1.0 5.4e-14 52.3 0.3 2.2 2 0 0 2 2 2 2 Carbohydrate binding domain CBM49 CBM_2 PF00553.19 ELR15653.1 - 3.6e-05 24.0 4.5 0.097 13.0 0.6 2.4 2 0 0 2 2 2 2 Cellulose binding domain DUF2393 PF09624.10 ELR15653.1 - 0.16 11.9 0.1 2.3 8.2 0.0 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF2393) Isochorismatase PF00857.20 ELR15654.1 - 2e-26 93.2 0.0 2.8e-26 92.8 0.0 1.2 1 0 0 1 1 1 1 Isochorismatase family TPR_1 PF00515.28 ELR15655.1 - 9.9e-11 41.0 15.5 0.00067 19.4 0.7 6.0 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_2 PF07719.17 ELR15655.1 - 2.6e-08 33.4 11.6 0.032 14.4 1.3 5.8 6 1 1 7 7 6 3 Tetratricopeptide repeat TPR_11 PF13414.6 ELR15655.1 - 5.9e-08 32.3 0.4 0.0069 16.1 0.1 3.9 4 0 0 4 4 4 2 TPR repeat TPR_17 PF13431.6 ELR15655.1 - 2.7e-06 27.4 0.1 0.28 11.6 0.0 3.5 4 0 0 4 4 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 ELR15655.1 - 0.00038 20.5 0.3 5.7 7.4 0.0 4.7 4 0 0 4 4 3 1 Tetratricopeptide repeat Rootletin PF15035.6 ELR15655.1 - 0.0073 16.3 2.3 0.15 12.0 0.1 2.4 3 0 0 3 3 2 1 Ciliary rootlet component, centrosome cohesion TPR_16 PF13432.6 ELR15655.1 - 0.018 15.7 1.6 0.45 11.2 0.0 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF4164 PF13747.6 ELR15655.1 - 0.03 14.6 4.6 0.079 13.2 0.1 3.1 3 1 0 3 3 3 0 Domain of unknown function (DUF4164) TPR_9 PF13371.6 ELR15655.1 - 0.042 14.0 0.3 0.74 10.0 0.0 2.8 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_19 PF14559.6 ELR15655.1 - 0.076 13.5 2.4 16 6.1 0.0 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat POTRA PF07244.15 ELR15655.1 - 0.1 13.2 1.4 1.4 9.6 0.1 2.5 2 0 0 2 2 2 0 Surface antigen variable number repeat Prefoldin PF02996.17 ELR15655.1 - 0.13 12.2 2.7 0.54 10.2 0.2 2.5 2 0 0 2 2 2 0 Prefoldin subunit IMPa_helical PF18642.1 ELR15655.1 - 0.2 12.1 3.2 5.3 7.5 0.1 3.4 2 1 1 3 3 3 0 Immunomodulating metalloprotease helical domain TPR_14 PF13428.6 ELR15655.1 - 0.49 11.4 6.1 4.6 8.3 0.7 4.2 4 1 1 5 5 5 0 Tetratricopeptide repeat ThrE PF06738.12 ELR15656.1 - 6.9e-31 107.5 9.9 5.9e-27 94.6 8.1 2.8 3 0 0 3 3 3 2 Putative threonine/serine exporter ThrE_2 PF12821.7 ELR15656.1 - 0.0034 17.5 22.8 0.074 13.2 10.1 2.5 2 0 0 2 2 2 2 Threonine/Serine exporter, ThrE DUF1211 PF06736.11 ELR15657.1 - 1.4e-15 57.5 20.3 6e-14 52.3 1.1 3.3 2 1 1 3 3 3 2 Protein of unknown function (DUF1211) TT_ORF1 PF02956.14 ELR15658.1 - 1.8 7.2 10.3 1.7 7.2 10.3 1.1 1 0 0 1 1 1 0 TT viral orf 1 Fer2 PF00111.27 ELR15659.1 - 3.1e-12 46.3 0.1 4.2e-12 45.8 0.1 1.2 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain SNAPc19 PF15497.6 ELR15661.1 - 0.00021 21.7 4.2 0.00021 21.7 4.2 2.2 2 1 0 2 2 2 1 snRNA-activating protein complex subunit 19, SNAPc subunit 19 Tex_N PF09371.10 ELR15661.1 - 0.016 14.9 4.3 0.026 14.2 4.3 1.4 1 1 0 1 1 1 0 Tex-like protein N-terminal domain DUF5094 PF17015.5 ELR15661.1 - 0.098 12.8 4.1 0.11 12.7 4.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF5094) OrfB_IS605 PF01385.19 ELR15661.1 - 0.19 12.0 3.6 0.29 11.4 3.6 1.4 1 1 0 1 1 1 0 Probable transposase WD40 PF00400.32 ELR15662.1 - 4.9e-41 137.9 10.1 3.3e-09 37.2 0.1 8.1 7 1 1 8 8 8 8 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ELR15662.1 - 2.9e-14 53.1 1.1 0.019 15.3 0.0 5.4 1 1 5 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ELR15662.1 - 6.7e-08 31.6 3.1 0.15 10.7 0.1 4.8 2 1 2 5 5 5 3 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 ELR15662.1 - 4.5e-06 25.9 0.0 0.077 11.9 0.0 4.3 3 1 1 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ELR15662.1 - 0.00023 21.1 0.1 0.37 10.6 0.0 2.5 2 0 0 2 2 2 2 Eukaryotic translation initiation factor eIF2A PALB2_WD40 PF16756.5 ELR15662.1 - 0.00098 18.1 1.3 0.75 8.6 0.0 3.1 2 2 0 3 3 3 2 Partner and localizer of BRCA2 WD40 domain Frtz PF11768.8 ELR15662.1 - 0.0015 16.9 0.0 0.0027 16.1 0.0 1.5 1 0 0 1 1 1 1 WD repeat-containing and planar cell polarity effector protein Fritz Nucleoporin_N PF08801.11 ELR15662.1 - 0.0024 16.7 0.1 3.4 6.3 0.0 3.5 2 1 2 4 4 4 2 Nup133 N terminal like Cytochrom_D1 PF02239.16 ELR15662.1 - 0.0032 16.1 0.0 1.3 7.4 0.0 2.3 1 1 1 2 2 2 2 Cytochrome D1 heme domain WD40_3 PF15911.5 ELR15662.1 - 0.022 14.7 0.0 0.059 13.4 0.0 1.8 1 0 0 1 1 1 0 WD domain, G-beta repeat Hira PF07569.11 ELR15662.1 - 0.071 12.8 0.2 3.8 7.2 0.1 3.3 1 1 1 2 2 2 0 TUP1-like enhancer of split IKI3 PF04762.12 ELR15662.1 - 0.14 10.2 0.1 4.4 5.2 0.0 1.8 1 1 1 2 2 2 0 IKI3 family FMN_red PF03358.15 ELR15663.1 - 1.7e-34 118.8 0.0 2.1e-34 118.5 0.0 1.1 1 0 0 1 1 1 1 NADPH-dependent FMN reductase Flavodoxin_2 PF02525.17 ELR15663.1 - 1.8e-05 24.6 0.0 3.8e-05 23.5 0.0 1.6 1 1 0 1 1 1 1 Flavodoxin-like fold ORC3_N PF07034.11 ELR15664.1 - 1.3e-50 172.5 0.0 2.1e-50 171.7 0.0 1.3 1 0 0 1 1 1 1 Origin recognition complex (ORC) subunit 3 N-terminus T4_deiodinase PF00837.17 ELR15664.1 - 0.039 13.2 0.0 0.065 12.5 0.0 1.2 1 0 0 1 1 1 0 Iodothyronine deiodinase ORC_WH_C PF18137.1 ELR15665.1 - 4.9e-19 68.8 4.0 4.1e-18 65.8 1.0 2.7 2 1 0 2 2 2 1 Origin recognition complex winged helix C-terminal DUF4525 PF15027.6 ELR15665.1 - 0.12 12.1 0.0 0.3 10.8 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4525) DUF908 PF06012.12 ELR15665.1 - 1.2 8.5 9.6 1.7 8.0 3.8 2.2 2 0 0 2 2 2 0 Domain of Unknown Function (DUF908) RPN2_C PF18004.1 ELR15665.1 - 1.7 8.5 12.9 3.4 7.6 12.9 1.4 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain Pox_Ag35 PF03286.14 ELR15665.1 - 3.9 7.2 14.5 1.4 8.7 11.5 1.7 2 0 0 2 2 2 0 Pox virus Ag35 surface protein DUF3618 PF12277.8 ELR15665.1 - 5.7 7.3 9.9 0.091 13.0 2.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3618) DPBB_1 PF03330.18 ELR15666.1 - 6.4e-17 61.6 2.3 2.5e-16 59.7 2.7 1.8 2 0 0 2 2 2 1 Lytic transglycolase Pollen_allerg_1 PF01357.21 ELR15666.1 - 7e-11 42.0 1.3 1.4e-10 41.1 1.3 1.5 1 0 0 1 1 1 1 Pollen allergen DPBB_1 PF03330.18 ELR15667.1 - 1.2e-17 64.0 1.4 3.4e-17 62.5 1.4 1.8 1 0 0 1 1 1 1 Lytic transglycolase Pollen_allerg_1 PF01357.21 ELR15667.1 - 6.6e-10 38.9 1.0 1.3e-09 38.0 1.0 1.5 1 0 0 1 1 1 1 Pollen allergen UQ_con PF00179.26 ELR15668.1 - 4.7e-23 81.4 0.0 6.6e-23 80.9 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme SAM_1 PF00536.30 ELR15668.1 - 3.9e-05 24.0 0.0 6.6e-05 23.3 0.0 1.3 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) DPBB_1 PF03330.18 ELR15669.1 - 3.7e-18 65.6 0.8 9.3e-18 64.3 0.8 1.7 1 0 0 1 1 1 1 Lytic transglycolase Pollen_allerg_1 PF01357.21 ELR15669.1 - 2.1e-11 43.7 0.8 3.9e-11 42.8 0.8 1.4 1 0 0 1 1 1 1 Pollen allergen Clat_adaptor_s PF01217.20 ELR15670.1 - 4e-35 120.8 2.1 4.5e-35 120.6 2.1 1.0 1 0 0 1 1 1 1 Clathrin adaptor complex small chain MRG PF05712.13 ELR15670.1 - 0.0068 15.7 0.2 0.0068 15.7 0.2 1.2 1 0 0 1 1 1 1 MRG Auto_anti-p27 PF06677.12 ELR15671.1 - 5.9e-06 26.3 10.4 0.00011 22.3 10.4 2.2 1 1 0 1 1 1 1 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) DNA_pack_N PF02500.15 ELR15671.1 - 0.59 9.9 2.3 1.2 8.9 0.6 1.9 2 0 0 2 2 2 0 Probable DNA packing protein, N-terminus PAT1 PF09770.9 ELR15671.1 - 1.1 7.4 6.6 1.4 7.1 6.6 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 AAA_18 PF13238.6 ELR15672.1 - 2.3e-07 31.4 0.0 4.8e-07 30.4 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 ELR15672.1 - 1.1e-05 25.7 0.0 2.3e-05 24.6 0.0 1.6 1 0 0 1 1 1 1 AAA domain Zeta_toxin PF06414.12 ELR15672.1 - 0.00047 19.5 0.0 0.0017 17.7 0.0 1.9 1 1 1 2 2 2 1 Zeta toxin AAA_28 PF13521.6 ELR15672.1 - 0.0034 17.7 0.0 0.0082 16.4 0.0 1.7 1 0 0 1 1 1 1 AAA domain APS_kinase PF01583.20 ELR15672.1 - 0.016 15.1 0.0 0.029 14.3 0.0 1.4 1 0 0 1 1 1 0 Adenylylsulphate kinase RsgA_GTPase PF03193.16 ELR15672.1 - 0.024 14.5 0.0 0.06 13.2 0.0 1.6 1 0 0 1 1 1 0 RsgA GTPase ABC_tran PF00005.27 ELR15672.1 - 0.027 15.0 0.0 0.066 13.7 0.0 1.7 1 0 0 1 1 1 0 ABC transporter RNA_helicase PF00910.22 ELR15672.1 - 0.043 14.2 0.0 0.12 12.8 0.0 1.8 1 0 0 1 1 1 0 RNA helicase AAA_16 PF13191.6 ELR15672.1 - 0.044 14.2 0.0 0.1 12.9 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain AAA_17 PF13207.6 ELR15672.1 - 0.048 14.1 0.0 0.13 12.6 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.6 ELR15672.1 - 0.076 12.8 0.1 0.16 11.8 0.1 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain Rad17 PF03215.15 ELR15672.1 - 0.085 12.8 0.0 0.17 11.8 0.0 1.4 1 0 0 1 1 1 0 Rad17 P-loop domain AAA PF00004.29 ELR15672.1 - 0.088 13.2 0.0 0.16 12.4 0.0 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) TRM13 PF05206.14 ELR15672.1 - 0.09 12.3 0.1 0.19 11.2 0.1 1.5 1 0 0 1 1 1 0 Methyltransferase TRM13 AAA_25 PF13481.6 ELR15672.1 - 0.11 12.1 0.0 0.21 11.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain tRNA_lig_kinase PF08303.11 ELR15672.1 - 0.17 12.0 0.1 2.2 8.3 0.0 2.1 2 0 0 2 2 2 0 tRNA ligase kinase domain Ras PF00071.22 ELR15674.1 - 1.3e-49 168.0 0.1 1.5e-49 167.7 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR15674.1 - 2.7e-19 69.5 0.0 3.8e-19 69.1 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR15674.1 - 1.1e-10 41.3 0.0 1.3e-10 41.0 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 ELR15674.1 - 1.9e-05 24.3 0.2 6.6e-05 22.5 0.2 1.8 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 ELR15674.1 - 0.0042 17.2 0.0 0.008 16.3 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 ELR15674.1 - 0.018 14.4 0.0 0.023 14.1 0.0 1.2 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 ELR15674.1 - 0.023 14.6 0.0 1.5 8.7 0.0 2.2 2 1 0 2 2 2 0 RsgA GTPase DUF4534 PF15049.6 ELR15677.1 - 0.12 12.1 5.8 0.051 13.3 1.6 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF4534) Thaumatin PF00314.17 ELR15678.1 - 1.3e-20 74.0 18.0 1.4e-17 64.1 18.0 3.2 1 1 0 1 1 1 1 Thaumatin family UEV PF05743.13 ELR15680.1 - 8.3e-25 87.0 0.1 8.3e-25 87.0 0.1 2.1 2 0 0 2 2 2 1 UEV domain Vps23_core PF09454.10 ELR15680.1 - 2.3e-18 65.9 0.8 4.4e-18 65.0 0.1 1.8 2 0 0 2 2 2 1 Vps23 core domain UQ_con PF00179.26 ELR15680.1 - 0.0029 17.3 0.1 0.0029 17.3 0.1 2.2 2 1 0 2 2 2 1 Ubiquitin-conjugating enzyme DDHD PF02862.17 ELR15680.1 - 0.93 9.6 10.4 0.034 14.3 1.9 2.1 2 0 0 2 2 2 0 DDHD domain NPL4 PF05021.15 ELR15682.1 - 3.4e-30 105.5 0.1 5.7e-22 78.5 0.3 2.9 2 1 0 2 2 2 2 NPL4 family UN_NPL4 PF11543.8 ELR15682.1 - 1.2e-10 41.7 0.0 3.2e-09 37.1 0.1 2.3 2 0 0 2 2 2 1 Nuclear pore localisation protein NPL4 ubiquitin PF00240.23 ELR15682.1 - 2.4e-05 24.0 0.1 0.0001 22.0 0.0 2.2 2 0 0 2 2 2 1 Ubiquitin family Ubiquitin_2 PF14560.6 ELR15682.1 - 0.00097 19.6 0.1 0.0028 18.1 0.1 1.8 1 0 0 1 1 1 1 Ubiquitin-like domain YukD PF08817.10 ELR15682.1 - 0.12 13.0 0.0 0.28 11.9 0.0 1.6 1 0 0 1 1 1 0 WXG100 protein secretion system (Wss), protein YukD RNA_polI_A14 PF08203.11 ELR15683.1 - 0.35 11.6 3.5 0.35 11.6 0.0 2.7 2 1 0 2 2 2 0 Yeast RNA polymerase I subunit RPA14 MJ1316 PF04457.12 ELR15684.1 - 2.2e-16 60.3 0.1 5.9e-16 59.0 0.1 1.8 1 0 0 1 1 1 1 MJ1316 RNA cyclic group end recognition domain NUDIX PF00293.28 ELR15684.1 - 2.1e-14 53.7 0.0 6.9e-14 52.0 0.0 1.9 1 0 0 1 1 1 1 NUDIX domain IMUP PF15761.5 ELR15684.1 - 0.012 16.3 2.9 0.012 16.3 2.9 3.4 3 0 0 3 3 3 0 Immortalisation up-regulated protein zf-RanBP PF00641.18 ELR15684.1 - 0.026 13.8 6.5 0.043 13.1 6.5 1.3 1 0 0 1 1 1 0 Zn-finger in Ran binding protein and others GlutR_dimer PF00745.20 ELR15684.1 - 0.035 14.5 0.2 0.035 14.5 0.2 2.2 2 0 0 2 2 2 0 Glutamyl-tRNAGlu reductase, dimerisation domain LPP PF04728.13 ELR15684.1 - 0.054 13.9 3.1 0.24 11.8 0.8 2.6 2 0 0 2 2 2 0 Lipoprotein leucine-zipper NUDIX_2 PF13869.6 ELR15684.1 - 0.16 11.5 0.2 0.62 9.6 0.0 1.9 2 0 0 2 2 2 0 Nucleotide hydrolase Bap31 PF05529.12 ELR15684.1 - 1.4 8.8 2.3 1 9.2 0.5 1.6 2 0 0 2 2 2 0 Bap31/Bap29 transmembrane region DUF3446 PF11928.8 ELR15684.1 - 2.1 8.7 12.6 2.5 8.5 2.2 2.3 2 0 0 2 2 2 0 Early growth response N-terminal domain Utp14 PF04615.13 ELR15684.1 - 2.1 6.8 24.7 2 6.9 19.2 2.2 2 0 0 2 2 2 0 Utp14 protein Mpp10 PF04006.12 ELR15684.1 - 9.3 4.5 26.2 0.88 7.9 20.3 2.0 2 0 0 2 2 2 0 Mpp10 protein Cupin_8 PF13621.6 ELR15685.1 - 7.2e-34 117.6 0.0 1.3e-33 116.8 0.0 1.3 1 0 0 1 1 1 1 Cupin-like domain Cupin_4 PF08007.12 ELR15685.1 - 2.6e-11 43.5 1.0 7.4e-11 42.1 1.0 1.7 1 1 0 1 1 1 1 Cupin superfamily protein JmjC PF02373.22 ELR15685.1 - 5.8e-05 23.5 0.0 0.00017 22.0 0.0 1.9 1 1 1 2 2 2 1 JmjC domain, hydroxylase FHA PF00498.26 ELR15686.1 - 3.8e-05 24.0 0.3 6e-05 23.3 0.3 1.3 1 0 0 1 1 1 1 FHA domain Yop-YscD_cpl PF16697.5 ELR15686.1 - 0.0013 19.0 0.0 0.0026 18.0 0.0 1.5 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain Sporozoite_P67 PF05642.11 ELR15686.1 - 0.064 11.3 8.1 0.083 11.0 8.1 1.3 1 0 0 1 1 1 0 Sporozoite P67 surface antigen SPX PF03105.19 ELR15686.1 - 0.13 12.1 4.4 0.16 11.8 4.4 1.2 1 0 0 1 1 1 0 SPX domain FHA_2 PF17913.1 ELR15686.1 - 0.13 12.5 0.0 0.23 11.7 0.0 1.4 1 0 0 1 1 1 0 FHA domain Macoilin PF09726.9 ELR15686.1 - 1.9 7.0 4.4 2.3 6.7 4.4 1.1 1 0 0 1 1 1 0 Macoilin family zf-RING_2 PF13639.6 ELR15687.1 - 6.7e-05 23.1 14.9 0.00015 22.0 14.9 1.7 1 0 0 1 1 1 1 Ring finger domain FANCL_C PF11793.8 ELR15687.1 - 0.0044 17.2 8.3 0.011 15.9 8.3 1.7 1 0 0 1 1 1 1 FANCL C-terminal domain Tti2 PF10521.9 ELR15687.1 - 0.011 15.3 0.4 0.23 11.0 0.0 3.1 4 0 0 4 4 4 0 Tti2 family Vac14_Fab1_bd PF12755.7 ELR15687.1 - 0.016 15.8 0.0 0.096 13.3 0.0 2.3 2 0 0 2 2 2 0 Vacuolar 14 Fab1-binding region HEAT PF02985.22 ELR15687.1 - 0.043 14.1 1.6 1 9.8 0.1 4.2 4 0 0 4 4 4 0 HEAT repeat zf-ANAPC11 PF12861.7 ELR15687.1 - 0.057 13.5 6.7 0.12 12.5 6.7 1.5 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-rbx1 PF12678.7 ELR15687.1 - 0.092 13.0 11.8 0.22 11.9 11.8 1.7 1 0 0 1 1 1 0 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 ELR15687.1 - 0.11 12.4 11.4 0.22 11.4 11.4 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) HEAT_EZ PF13513.6 ELR15687.1 - 0.16 12.5 4.7 4.6 7.9 0.0 4.5 4 0 0 4 4 4 0 HEAT-like repeat zf-RING-like PF08746.11 ELR15687.1 - 0.4 11.0 7.0 0.94 9.8 7.0 1.6 1 0 0 1 1 1 0 RING-like domain RINGv PF12906.7 ELR15687.1 - 0.69 10.1 8.3 1.5 9.0 8.3 1.6 1 0 0 1 1 1 0 RING-variant domain C1_1 PF00130.22 ELR15687.1 - 1.7 8.6 10.6 3.6 7.6 10.6 1.6 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-RING_4 PF14570.6 ELR15687.1 - 2.9 7.7 7.1 5.5 6.9 7.1 1.5 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain HSDR_N_2 PF13588.6 ELR15689.1 - 0.0015 18.5 0.0 0.003 17.5 0.0 1.4 1 0 0 1 1 1 1 Type I restriction enzyme R protein N terminus (HSDR_N) HSDR_N PF04313.14 ELR15689.1 - 0.04 13.9 0.0 0.07 13.1 0.0 1.4 1 0 0 1 1 1 0 Type I restriction enzyme R protein N terminus (HSDR_N) KorB_C PF06613.11 ELR15689.1 - 2.2 8.3 5.0 10 6.2 4.6 2.3 2 1 0 2 2 2 0 KorB C-terminal beta-barrel domain DUF547 PF04784.14 ELR15690.1 - 0.13 12.3 0.1 0.69 10.0 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function, DUF547 CRA PF06589.11 ELR15692.1 - 2.1 8.5 7.8 2.5 8.2 7.8 1.2 1 0 0 1 1 1 0 Circumsporozoite-related antigen (CRA) Fra10Ac1 PF09725.9 ELR15693.1 - 2.2e-49 166.7 3.6 2.2e-49 166.7 3.6 2.1 2 1 0 2 2 2 1 Folate-sensitive fragile site protein Fra10Ac1 DUF4746 PF15928.5 ELR15693.1 - 0.026 14.0 15.0 0.038 13.4 15.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Neur_chan_memb PF02932.16 ELR15693.1 - 3.8 7.5 5.0 4.1 7.4 5.0 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region vMSA PF00695.19 ELR15695.1 - 2.3 7.2 7.9 3.7 6.5 7.9 1.2 1 0 0 1 1 1 0 Major surface antigen from hepadnavirus Peptidase_C12 PF01088.21 ELR15698.1 - 2.3e-53 181.1 0.0 2.8e-53 180.8 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase, family 1 Git3 PF11710.8 ELR15699.1 - 1.2e-11 44.7 10.5 2.7e-11 43.6 10.5 1.5 1 0 0 1 1 1 1 G protein-coupled glucose receptor regulating Gpa2 7tm_1 PF00001.21 ELR15699.1 - 3e-09 36.6 11.1 4.1e-09 36.1 11.1 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Dicty_CAR PF05462.11 ELR15699.1 - 1.8e-06 27.3 14.0 4e-06 26.2 14.0 1.5 1 1 0 1 1 1 1 Slime mold cyclic AMP receptor GPR_Gpa2_C PF11970.8 ELR15699.1 - 3e-06 27.2 1.6 4.6e-06 26.6 0.2 2.1 2 0 0 2 2 2 1 G protein-coupled glucose receptor regulating Gpa2 C-term 7TM_GPCR_Srx PF10328.9 ELR15699.1 - 0.011 15.3 5.8 0.021 14.5 5.8 1.4 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srx DAGK_acc PF00609.19 ELR15700.1 - 3.8e-35 121.6 0.0 6.3e-35 120.9 0.0 1.4 1 0 0 1 1 1 1 Diacylglycerol kinase accessory domain DAGK_cat PF00781.24 ELR15700.1 - 1.3e-21 76.5 0.0 2.2e-21 75.8 0.0 1.4 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain SPATIAL PF15256.6 ELR15700.1 - 8.6 6.6 11.1 2.8 8.2 0.7 3.3 4 0 0 4 4 4 0 SPATIAL VWA PF00092.28 ELR15701.1 - 6.2e-07 29.8 0.0 9.9e-07 29.2 0.0 1.5 1 1 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.6 ELR15701.1 - 0.00084 20.0 0.0 0.0034 18.0 0.0 1.9 1 1 0 1 1 1 1 von Willebrand factor type A domain Helicase_C PF00271.31 ELR15702.1 - 1.7e-17 63.7 0.1 5.2e-17 62.2 0.0 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 ELR15702.1 - 5.5e-17 62.1 0.0 1.1e-16 61.1 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase RecQ_Zn_bind PF16124.5 ELR15702.1 - 2.6e-12 47.3 6.5 2.6e-12 47.3 6.5 2.5 2 0 0 2 2 2 1 RecQ zinc-binding RQC PF09382.10 ELR15702.1 - 2.3e-07 30.6 0.0 5.5e-06 26.1 0.0 2.3 2 0 0 2 2 2 1 RQC domain ResIII PF04851.15 ELR15702.1 - 0.0021 18.1 0.0 0.0073 16.3 0.0 1.9 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit SNF2_N PF00176.23 ELR15702.1 - 0.01 14.6 0.0 0.055 12.2 0.1 1.9 1 1 0 1 1 1 0 SNF2 family N-terminal domain DUF2996 PF11210.8 ELR15702.1 - 0.014 15.8 0.4 0.053 14.0 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2996) AAA_22 PF13401.6 ELR15702.1 - 0.12 12.7 0.0 0.73 10.1 0.0 2.3 1 1 0 1 1 1 0 AAA domain PDDEXK_10 PF07788.11 ELR15702.1 - 0.13 12.2 0.0 0.39 10.7 0.0 1.8 1 0 0 1 1 1 0 PD-(D/E)XK nuclease superfamily DUF3052 PF11253.8 ELR15702.1 - 0.16 11.9 0.0 0.47 10.4 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3052) DUF3511 PF12023.8 ELR15702.1 - 0.25 11.2 1.0 0.54 10.1 1.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3511) adh_short PF00106.25 ELR15703.1 - 6.4e-31 107.3 2.1 3.2e-29 101.8 2.1 2.4 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ELR15703.1 - 1.2e-19 70.8 0.9 5.8e-18 65.3 0.9 2.2 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase PX PF00787.24 ELR15703.1 - 2.4e-12 46.8 0.8 5e-12 45.8 0.8 1.5 1 0 0 1 1 1 1 PX domain KR PF08659.10 ELR15703.1 - 0.00015 21.7 0.1 0.00027 20.9 0.1 1.3 1 0 0 1 1 1 1 KR domain Eno-Rase_NADH_b PF12242.8 ELR15703.1 - 0.069 12.9 0.1 0.19 11.5 0.1 1.8 1 0 0 1 1 1 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase Lin-8 PF03353.15 ELR15703.1 - 6.3 6.3 6.4 7.4 6.0 5.5 1.4 1 1 0 1 1 1 0 Ras-mediated vulval-induction antagonist Ribosomal_L5e PF17144.4 ELR15704.1 - 5e-82 273.7 0.9 7.5e-82 273.2 0.9 1.3 1 0 0 1 1 1 1 Ribosomal large subunit proteins 60S L5, and 50S L18 Ribosomal_L18_c PF14204.6 ELR15704.1 - 2.7e-32 111.6 3.4 2.7e-32 111.6 3.4 2.0 2 0 0 2 2 2 1 Ribosomal L18 C-terminal region LPD22 PF18834.1 ELR15704.1 - 0.067 13.4 1.2 0.13 12.5 1.2 1.4 1 0 0 1 1 1 0 Large polyvalent protein associated domain 22 Peptidase_M24 PF00557.24 ELR15705.1 - 1.8e-57 194.5 0.0 2.6e-57 193.9 0.0 1.3 1 0 0 1 1 1 1 Metallopeptidase family M24 AMP_N PF05195.16 ELR15705.1 - 4.2e-39 133.1 0.0 7.6e-39 132.2 0.0 1.4 1 0 0 1 1 1 1 Aminopeptidase P, N-terminal domain Creatinase_N PF01321.18 ELR15705.1 - 0.063 13.9 0.0 0.12 13.0 0.0 1.4 1 0 0 1 1 1 0 Creatinase/Prolidase N-terminal domain F_actin_bund_C PF18060.1 ELR15706.1 - 9e-26 89.8 16.9 9e-26 89.8 16.9 2.3 1 1 1 2 2 2 1 F actin bundling C terminal Macoilin PF09726.9 ELR15706.1 - 1.7e-05 23.7 11.8 1.8e-05 23.5 11.8 1.1 1 0 0 1 1 1 1 Macoilin family BPL_N PF09825.9 ELR15706.1 - 0.039 13.0 3.0 0.05 12.7 3.0 1.0 1 0 0 1 1 1 0 Biotin-protein ligase, N terminal GAGA_bind PF06217.12 ELR15706.1 - 0.84 9.9 7.5 1.1 9.5 7.5 1.2 1 0 0 1 1 1 0 GAGA binding protein-like family RR_TM4-6 PF06459.12 ELR15706.1 - 2.3 8.0 12.4 3.2 7.5 12.4 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Borrelia_P83 PF05262.11 ELR15706.1 - 3.9 5.8 15.4 4.8 5.6 15.4 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein DUF1509 PF07420.11 ELR15706.1 - 6 5.7 8.9 8.2 5.3 8.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1509) U79_P34 PF03064.16 ELR15706.1 - 6.3 6.1 14.4 11 5.4 14.4 1.4 1 0 0 1 1 1 0 HSV U79 / HCMV P34 Polbeta PF18765.1 ELR15707.1 - 0.0002 21.4 0.0 0.00036 20.5 0.0 1.5 1 0 0 1 1 1 1 Polymerase beta, Nucleotidyltransferase NTP_transf_2 PF01909.23 ELR15707.1 - 0.0067 16.7 0.0 0.01 16.1 0.0 1.5 1 1 0 1 1 1 1 Nucleotidyltransferase domain F-box-like PF12937.7 ELR15708.1 - 9.6e-05 22.2 0.4 0.0002 21.2 0.4 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ELR15708.1 - 0.053 13.4 0.3 0.11 12.4 0.3 1.6 1 0 0 1 1 1 0 F-box domain DDE_Tnp_IS66 PF03050.14 ELR15708.1 - 0.068 12.6 0.0 0.085 12.3 0.0 1.1 1 0 0 1 1 1 0 Transposase IS66 family DinB_2 PF12867.7 ELR15708.1 - 0.12 12.9 0.5 0.2 12.2 0.5 1.3 1 1 0 1 1 1 0 DinB superfamily RNA_lig_T4_1 PF09511.10 ELR15709.1 - 4.5e-11 43.0 0.0 8.1e-05 22.6 0.0 2.7 2 1 0 2 2 2 2 RNA ligase RNA_ligase PF09414.10 ELR15709.1 - 9.3e-05 22.8 0.0 0.68 10.2 0.0 2.4 2 0 0 2 2 2 2 RNA ligase DUF5565 PF17720.1 ELR15709.1 - 0.0036 16.2 0.1 3.3 6.5 0.0 2.7 3 0 0 3 3 3 2 Family of unknown function (DUF5565) LIX1 PF14954.6 ELR15709.1 - 0.033 13.5 0.2 9.3 5.5 0.0 2.6 3 0 0 3 3 3 0 Limb expression 1 BTRD1 PF17660.1 ELR15709.1 - 0.052 13.4 0.0 20 5.1 0.0 2.7 2 0 0 2 2 2 0 Bacterial tandem repeat domain 1 PglL_A PF15864.5 ELR15709.1 - 2.5 7.9 3.9 18 5.2 0.7 2.5 2 0 0 2 2 2 0 Protein glycosylation ligase GLE1 PF07817.13 ELR15710.1 - 8.5e-28 97.2 0.0 1.2e-27 96.7 0.0 1.2 1 0 0 1 1 1 1 GLE1-like protein DDE_Tnp_4 PF13359.6 ELR15711.1 - 2e-13 50.3 0.0 5.9e-13 48.8 0.0 1.8 1 1 0 1 1 1 1 DDE superfamily endonuclease Hc1 PF07432.13 ELR15711.1 - 0.034 14.5 17.8 0.072 13.5 17.8 1.5 1 0 0 1 1 1 0 Histone H1-like protein Hc1 Vfa1 PF08432.10 ELR15711.1 - 2.3 8.5 11.5 15 5.9 7.7 2.3 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 AAA-ATPase_like PF09820.9 ELR15712.1 - 1.6e-54 185.3 0.0 2.1e-54 184.8 0.0 1.1 1 0 0 1 1 1 1 Predicted AAA-ATPase AAA_14 PF13173.6 ELR15712.1 - 0.084 12.9 0.1 3.9 7.5 0.0 2.7 2 1 1 3 3 3 0 AAA domain AAA-ATPase_like PF09820.9 ELR15713.1 - 5.1e-13 49.1 0.1 9.9e-13 48.1 0.0 1.5 2 0 0 2 2 2 1 Predicted AAA-ATPase SapB_1 PF05184.15 ELR15714.1 - 3.8e-05 23.6 0.7 0.00017 21.6 0.2 2.2 2 0 0 2 2 2 1 Saposin-like type B, region 1 SapB_2 PF03489.17 ELR15714.1 - 7.7e-05 22.7 2.3 7.8e-05 22.7 0.0 2.2 3 0 0 3 3 3 1 Saposin-like type B, region 2 Ras PF00071.22 ELR15715.1 - 2.6e-09 36.9 0.5 4.3e-05 23.2 0.1 2.5 2 0 0 2 2 2 2 Ras family Roc PF08477.13 ELR15715.1 - 4.1e-07 30.2 2.1 6.7e-07 29.6 0.8 2.0 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR15715.1 - 0.0033 16.9 0.2 0.064 12.7 0.1 2.2 2 0 0 2 2 2 1 ADP-ribosylation factor family BatD PF13584.6 ELR15716.1 - 0.027 13.3 0.1 0.032 13.1 0.1 1.0 1 0 0 1 1 1 0 Oxygen tolerance RabGAP-TBC PF00566.18 ELR15717.1 - 2.1e-43 148.5 0.1 3.1e-43 147.9 0.1 1.3 1 0 0 1 1 1 1 Rab-GTPase-TBC domain Pkinase PF00069.25 ELR15717.1 - 4.1e-26 91.9 0.0 6.3e-26 91.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR15717.1 - 1.5e-15 57.2 0.0 2.6e-15 56.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Rhodanese PF00581.20 ELR15717.1 - 9.3e-06 26.1 0.0 2.3e-05 24.8 0.0 1.7 1 0 0 1 1 1 1 Rhodanese-like domain Kinase-like PF14531.6 ELR15717.1 - 2.4e-05 23.8 0.0 4.1e-05 23.0 0.0 1.2 1 0 0 1 1 1 1 Kinase-like CDC45 PF02724.14 ELR15718.1 - 0.0057 15.0 11.3 0.008 14.5 11.3 1.1 1 0 0 1 1 1 1 CDC45-like protein Zip PF02535.22 ELR15718.1 - 0.56 9.4 2.7 0.66 9.1 2.7 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter RR_TM4-6 PF06459.12 ELR15718.1 - 1 9.2 9.2 1.6 8.5 9.2 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 MDFI PF15316.6 ELR15718.1 - 7.8 6.6 7.6 14 5.8 7.6 1.5 1 0 0 1 1 1 0 MyoD family inhibitor FAM176 PF14851.6 ELR15718.1 - 7.8 6.1 9.4 3.5 7.3 7.1 1.6 1 1 1 2 2 2 0 FAM176 family CAF1 PF04857.20 ELR15719.1 - 1e-20 74.2 0.0 1.3e-09 37.7 0.0 2.5 1 1 1 2 2 2 2 CAF1 family ribonuclease GATA PF00320.27 ELR15720.1 - 1e-05 25.0 0.8 2.4e-05 23.8 0.8 1.7 1 1 0 1 1 1 1 GATA zinc finger RNHCP PF12647.7 ELR15720.1 - 0.022 14.7 0.6 0.034 14.1 0.6 1.4 1 0 0 1 1 1 0 RNHCP domain AATF-Che1 PF13339.6 ELR15720.1 - 0.023 15.4 1.7 0.032 14.9 1.7 1.1 1 0 0 1 1 1 0 Apoptosis antagonizing transcription factor FUSC PF04632.12 ELR15720.1 - 0.048 12.2 1.5 0.049 12.2 1.5 1.0 1 0 0 1 1 1 0 Fusaric acid resistance protein family MCU PF04678.13 ELR15720.1 - 0.21 11.7 1.7 0.27 11.3 1.7 1.1 1 0 0 1 1 1 0 Mitochondrial calcium uniporter GATA PF00320.27 ELR15721.1 - 0.0001 21.8 0.5 0.00025 20.6 0.5 1.7 1 0 0 1 1 1 1 GATA zinc finger AATF-Che1 PF13339.6 ELR15721.1 - 0.016 15.9 0.6 0.02 15.5 0.6 1.1 1 0 0 1 1 1 0 Apoptosis antagonizing transcription factor Mut7-C PF01927.16 ELR15721.1 - 0.044 13.9 1.3 0.061 13.4 1.3 1.2 1 0 0 1 1 1 0 Mut7-C RNAse domain GATA PF00320.27 ELR15722.1 - 0.00047 19.7 1.1 0.0012 18.4 1.1 1.7 1 0 0 1 1 1 1 GATA zinc finger CENP-H PF05837.12 ELR15722.1 - 0.056 13.9 2.0 0.066 13.6 1.6 1.4 1 1 0 1 1 1 0 Centromere protein H (CENP-H) Diphthami_syn_2 PF01902.17 ELR15724.1 - 1.6e-36 125.9 0.0 5.7e-36 124.1 0.0 1.9 1 1 0 1 1 1 1 Diphthamide synthase Pkinase PF00069.25 ELR15725.1 - 3.6e-63 213.4 0.2 4.3e-63 213.1 0.2 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR15725.1 - 1.1e-16 61.0 0.0 1.5e-16 60.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 ELR15725.1 - 1.8e-08 34.7 0.0 1.3e-06 28.6 0.1 2.2 1 1 1 2 2 2 1 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 ELR15725.1 - 0.015 14.1 0.2 0.21 10.3 0.0 2.0 2 0 0 2 2 2 0 Fungal protein kinase Choline_kinase PF01633.20 ELR15725.1 - 0.031 13.9 0.1 0.062 12.9 0.1 1.5 1 0 0 1 1 1 0 Choline/ethanolamine kinase Kdo PF06293.14 ELR15725.1 - 0.11 11.9 0.1 0.22 10.8 0.1 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DUF302 PF03625.14 ELR15726.1 - 0.0068 16.3 0.0 0.015 15.2 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function DUF302 Phage_TAC_11 PF11836.8 ELR15726.1 - 0.1 12.8 0.1 0.71 10.0 0.1 2.3 1 1 1 2 2 2 0 Phage tail tube protein, GTA-gp10 Methyltransf_16 PF10294.9 ELR15726.1 - 0.15 11.8 0.0 0.46 10.2 0.0 1.9 2 1 0 2 2 2 0 Lysine methyltransferase GATA PF00320.27 ELR15727.1 - 4.5e-10 39.0 3.3 1.1e-09 37.7 3.3 1.7 1 0 0 1 1 1 1 GATA zinc finger Macoilin PF09726.9 ELR15727.1 - 0.066 11.8 2.0 0.068 11.7 2.0 1.1 1 0 0 1 1 1 0 Macoilin family QWRF PF04484.12 ELR15727.1 - 2 8.1 11.3 2.7 7.7 11.3 1.2 1 0 0 1 1 1 0 QWRF family NUDE_C PF04880.13 ELR15727.1 - 4 7.9 13.0 7.5 7.0 13.0 1.5 1 0 0 1 1 1 0 NUDE protein, C-terminal conserved region SPX PF03105.19 ELR15727.1 - 5.1 6.9 9.6 6 6.7 9.6 1.2 1 0 0 1 1 1 0 SPX domain DUF1294 PF06961.13 ELR15728.1 - 3.5e-21 75.2 0.2 6.3e-21 74.4 0.2 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1294) FXMRP1_C_core PF12235.8 ELR15728.1 - 0.35 11.5 9.6 0.44 11.2 9.6 1.2 1 0 0 1 1 1 0 Fragile X-related 1 protein core C terminal GTP_EFTU PF00009.27 ELR15730.1 - 1.5e-08 34.4 0.0 1.5e-08 34.4 0.0 1.1 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain C4bp_oligo PF18453.1 ELR15730.1 - 0.024 14.8 1.0 4.6 7.5 0.1 2.5 2 0 0 2 2 2 0 Oligomerization domain of C4b-binding protein alpha SnoaL_2 PF12680.7 ELR15731.1 - 9e-19 68.0 1.4 1.1e-18 67.8 1.4 1.1 1 0 0 1 1 1 1 SnoaL-like domain SnoaL PF07366.12 ELR15731.1 - 4.6e-05 23.2 0.2 6.5e-05 22.7 0.2 1.2 1 0 0 1 1 1 1 SnoaL-like polyketide cyclase SnoaL_3 PF13474.6 ELR15731.1 - 0.0015 18.8 0.2 0.0019 18.5 0.2 1.1 1 0 0 1 1 1 1 SnoaL-like domain SchA_CurD PF04486.12 ELR15731.1 - 0.068 13.3 0.1 0.087 12.9 0.1 1.2 1 0 0 1 1 1 0 SchA/CurD like domain CorA PF01544.18 ELR15732.1 - 1.9e-08 34.0 0.0 3.7e-08 33.0 0.0 1.4 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein DUF2721 PF11026.8 ELR15732.1 - 0.054 13.4 0.0 0.18 11.7 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2721) Reprolysin_3 PF13582.6 ELR15733.1 - 1.5e-15 57.8 0.1 2.6e-15 57.0 0.1 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_5 PF13688.6 ELR15733.1 - 8.6e-11 42.4 0.1 1.4e-10 41.6 0.1 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12 CBM49 PF09478.10 ELR15733.1 - 5.2e-10 39.5 0.1 1.6e-09 37.9 0.1 1.8 1 0 0 1 1 1 1 Carbohydrate binding domain CBM49 Reprolysin_4 PF13583.6 ELR15733.1 - 2.7e-07 30.4 2.6 6.3e-07 29.2 2.6 1.6 1 1 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_2 PF13574.6 ELR15733.1 - 3.9e-07 30.2 0.2 7e-07 29.3 0.2 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Peptidase_M10 PF00413.24 ELR15733.1 - 0.11 12.4 0.0 0.14 12.0 0.0 1.3 1 0 0 1 1 1 0 Matrixin U-box PF04564.15 ELR15735.1 - 4.4e-15 55.6 0.1 1.1e-14 54.4 0.1 1.6 1 0 0 1 1 1 1 U-box domain zf-RING_UBOX PF13445.6 ELR15735.1 - 2.3e-08 33.9 0.1 4.3e-08 33.1 0.1 1.5 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 ELR15735.1 - 2.7e-07 30.3 0.5 4.6e-07 29.6 0.5 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 ELR15735.1 - 1.4e-06 28.5 0.2 3.4e-06 27.3 0.2 1.6 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_2 PF13639.6 ELR15735.1 - 2.3e-06 27.8 0.3 4.1e-06 27.0 0.3 1.4 1 0 0 1 1 1 1 Ring finger domain zf-Nse PF11789.8 ELR15735.1 - 9.9e-06 25.3 0.2 1.8e-05 24.4 0.2 1.3 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-C3HC4_4 PF15227.6 ELR15735.1 - 2.4e-05 24.4 0.2 4.9e-05 23.4 0.2 1.5 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-C3HC4 PF00097.25 ELR15735.1 - 5.9e-05 22.9 0.2 0.0001 22.1 0.2 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ELR15735.1 - 0.016 15.2 0.1 0.028 14.4 0.1 1.4 1 0 0 1 1 1 0 zinc-RING finger domain zf-C3HC4_3 PF13920.6 ELR15735.1 - 0.025 14.4 0.1 0.047 13.6 0.1 1.3 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 ELR15735.1 - 0.063 13.2 0.1 0.12 12.3 0.1 1.4 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-ANAPC11 PF12861.7 ELR15735.1 - 0.099 12.7 0.2 0.19 11.8 0.2 1.4 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_10 PF16685.5 ELR15735.1 - 0.23 11.6 0.1 0.45 10.7 0.1 1.4 1 0 0 1 1 1 0 zinc RING finger of MSL2 Med3 PF11593.8 ELR15735.1 - 6.9 5.7 16.5 0.011 15.0 2.7 2.7 2 0 0 2 2 1 0 Mediator complex subunit 3 fungal VWA PF00092.28 ELR15736.1 - 4.7e-07 30.2 0.0 4.3e-05 23.8 0.0 3.0 2 1 0 2 2 2 1 von Willebrand factor type A domain VWA_2 PF13519.6 ELR15736.1 - 0.00058 20.5 0.0 0.018 15.7 0.0 2.4 2 0 0 2 2 2 1 von Willebrand factor type A domain VWA_3 PF13768.6 ELR15736.1 - 0.0021 18.0 0.1 0.03 14.3 0.0 2.2 2 0 0 2 2 2 1 von Willebrand factor type A domain EntA_Immun PF08951.10 ELR15736.1 - 0.17 12.2 0.3 0.58 10.6 0.1 1.9 2 0 0 2 2 2 0 Enterocin A Immunity Mob1_phocein PF03637.17 ELR15737.1 - 1.1e-24 87.4 1.1 1.3e-23 83.9 1.1 1.9 1 1 0 1 1 1 1 Mob1/phocein family Toxin_8 PF07365.12 ELR15739.1 - 0.0021 18.2 0.5 0.0041 17.3 0.5 1.4 1 0 0 1 1 1 1 Alpha conotoxin precursor Rhabdo_ncap PF00945.18 ELR15739.1 - 0.065 12.1 0.4 0.094 11.6 0.4 1.2 1 0 0 1 1 1 0 Rhabdovirus nucleocapsid protein PBP1_TM PF14812.6 ELR15739.1 - 1.6 9.1 10.7 2.5 8.5 8.3 2.2 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DNA_pol_phi PF04931.13 ELR15739.1 - 4 5.4 6.7 4.2 5.4 6.7 1.2 1 0 0 1 1 1 0 DNA polymerase phi PseudoU_synth_2 PF00849.22 ELR15740.1 - 9.6e-20 71.3 0.0 1.4e-19 70.7 0.0 1.3 1 0 0 1 1 1 1 RNA pseudouridylate synthase GTF2I PF02946.14 ELR15740.1 - 0.01 15.9 0.0 0.017 15.2 0.0 1.3 1 0 0 1 1 1 0 GTF2I-like repeat CNPase PF05881.12 ELR15740.1 - 0.099 12.2 0.0 0.15 11.6 0.0 1.3 1 0 0 1 1 1 0 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP or CNPase) Ras PF00071.22 ELR15741.1 - 9.4e-22 77.3 0.0 1.5e-21 76.7 0.0 1.3 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR15741.1 - 4.3e-18 65.7 0.0 9.4e-18 64.6 0.0 1.6 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase FYVE PF01363.21 ELR15741.1 - 2.8e-16 59.4 7.3 5e-16 58.6 7.3 1.4 1 0 0 1 1 1 1 FYVE zinc finger Arf PF00025.21 ELR15741.1 - 1.8e-11 43.8 0.0 1.3e-10 41.0 0.0 2.0 1 1 0 1 1 1 1 ADP-ribosylation factor family FYVE_2 PF02318.16 ELR15741.1 - 0.0033 17.6 3.6 0.006 16.8 3.6 1.5 1 0 0 1 1 1 1 FYVE-type zinc finger Gtr1_RagA PF04670.12 ELR15741.1 - 0.0054 16.1 0.0 0.0089 15.4 0.0 1.5 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 ELR15741.1 - 0.009 15.6 0.2 0.024 14.2 0.2 1.8 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1_Xtn PF16897.5 ELR15741.1 - 0.066 13.2 0.0 0.13 12.3 0.0 1.5 1 0 0 1 1 1 0 C-terminal region of MMR_HSR1 domain SeqA PF03925.13 ELR15741.1 - 0.08 12.9 0.0 0.16 11.9 0.0 1.4 1 0 0 1 1 1 0 SeqA protein C-terminal domain zf-C2HC5 PF06221.13 ELR15741.1 - 0.88 9.6 10.8 3.4 7.7 10.8 2.0 1 1 0 1 1 1 0 Putative zinc finger motif, C2HC5-type SR-25 PF10500.9 ELR15741.1 - 1.5 8.3 18.7 2.6 7.6 18.7 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein DUF515 PF04415.12 ELR15741.1 - 3.4 6.0 6.8 5.2 5.4 6.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF515) HypA PF01155.19 ELR15741.1 - 7.8 6.6 7.4 4.3 7.4 4.3 2.1 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA RRM_1 PF00076.22 ELR15742.1 - 1.9e-11 43.6 0.0 3.1e-11 42.9 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 ELR15742.1 - 0.15 11.9 0.0 0.24 11.3 0.0 1.3 1 0 0 1 1 1 0 Occluded RNA-recognition motif BTB_2 PF02214.22 ELR15743.1 - 4.4e-17 62.2 0.0 7.3e-17 61.5 0.0 1.3 1 0 0 1 1 1 1 BTB/POZ domain BTB PF00651.31 ELR15743.1 - 0.00043 20.5 0.0 0.00078 19.6 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain GAF PF01590.26 ELR15743.1 - 0.11 13.2 0.0 0.17 12.5 0.0 1.3 1 0 0 1 1 1 0 GAF domain SKA1 PF07160.12 ELR15744.1 - 0.00067 19.6 0.0 0.001 18.9 0.0 1.2 1 0 0 1 1 1 1 Spindle and kinetochore-associated protein 1 DUF3413 PF11893.8 ELR15744.1 - 0.92 8.6 4.8 1.4 8.0 4.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3413) Adaptin_N PF01602.20 ELR15745.1 - 5e-88 295.9 1.7 7.2e-88 295.4 1.7 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Coatomer_b_Cpla PF14806.6 ELR15745.1 - 2e-59 199.2 0.1 4.4e-59 198.0 0.1 1.6 1 0 0 1 1 1 1 Coatomer beta subunit appendage platform Coatamer_beta_C PF07718.12 ELR15745.1 - 6.9e-53 178.3 0.0 1.9e-52 176.9 0.0 1.8 1 0 0 1 1 1 1 Coatomer beta C-terminal region HEAT_2 PF13646.6 ELR15745.1 - 2e-10 40.9 0.9 0.05 14.0 0.0 5.2 3 3 2 5 5 5 3 HEAT repeats Cnd1 PF12717.7 ELR15745.1 - 6.5e-06 26.3 5.3 0.0004 20.5 0.0 4.0 1 1 2 3 3 3 1 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.22 ELR15745.1 - 0.00054 20.0 5.5 6.6 7.3 0.0 5.7 6 0 0 6 6 6 2 HEAT repeat Coatomer_g_Cpla PF16381.5 ELR15745.1 - 0.00071 19.7 0.0 0.0026 17.9 0.0 2.0 2 0 0 2 2 2 1 Coatomer subunit gamma-1 C-terminal appendage platform DUF5578 PF17741.1 ELR15745.1 - 0.049 13.1 0.4 2.1 7.7 0.0 2.7 2 1 1 3 3 3 0 Family of unknown function (DUF5578) Arm PF00514.23 ELR15745.1 - 0.05 13.7 0.1 0.65 10.1 0.0 3.1 3 0 0 3 3 3 0 Armadillo/beta-catenin-like repeat RNHCP PF12647.7 ELR15746.1 - 0.12 12.4 6.8 0.76 9.8 0.4 2.5 2 0 0 2 2 2 0 RNHCP domain CelTOS PF18659.1 ELR15747.1 - 0.17 12.3 0.0 0.73 10.3 0.0 2.0 2 0 0 2 2 2 0 Cell-traversal protein for ookinetes and sporozoites Phage_holin_3_7 PF05449.11 ELR15747.1 - 6.5 6.8 7.0 4.2 7.4 0.7 2.4 2 0 0 2 2 2 0 Putative 3TM holin, Phage_holin_3 WD40 PF00400.32 ELR15748.1 - 2.7e-21 75.5 1.7 1.3e-05 25.9 0.3 6.4 6 1 1 7 7 7 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ELR15748.1 - 2.1e-08 34.3 0.1 6.1 7.2 0.0 5.5 2 1 4 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ELR15748.1 - 9.8e-08 31.3 1.8 0.00053 19.1 0.5 3.2 2 1 1 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Coatomer_WDAD PF04053.14 ELR15748.1 - 0.00049 19.3 0.1 0.053 12.6 0.1 2.7 1 1 2 3 3 3 2 Coatomer WD associated region WD40_like PF17005.5 ELR15748.1 - 0.043 13.1 0.2 0.22 10.8 0.1 2.1 1 1 1 2 2 2 0 WD40-like domain PQQ_2 PF13360.6 ELR15748.1 - 0.055 13.0 0.0 2.2 7.8 0.0 2.3 1 1 1 2 2 2 0 PQQ-like domain DUF2561 PF10812.8 ELR15748.1 - 0.06 13.4 0.0 0.12 12.4 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2561) DSPc PF00782.20 ELR15749.1 - 2e-26 92.4 0.0 7.1e-26 90.6 0.0 1.9 1 1 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 ELR15749.1 - 0.0017 18.0 0.0 0.0023 17.6 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Init_tRNA_PT PF04179.12 ELR15749.1 - 0.0078 16.5 0.0 0.013 15.8 0.0 1.3 1 0 0 1 1 1 1 Rit1 DUSP-like domain PTPlike_phytase PF14566.6 ELR15749.1 - 0.12 12.4 0.0 0.28 11.3 0.0 1.6 1 0 0 1 1 1 0 Inositol hexakisphosphate Methyltransf_21 PF05050.12 ELR15750.1 - 9.4e-08 32.3 0.1 1.3e-07 31.8 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase FkbM domain Exo_endo_phos PF03372.23 ELR15751.1 - 2.2e-05 24.1 0.0 6.4e-05 22.6 0.0 1.8 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family DUF1180 PF06679.12 ELR15751.1 - 0.012 16.0 0.0 0.02 15.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) DUF4680 PF15730.5 ELR15751.1 - 0.56 10.6 2.7 1 9.7 2.7 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4680) DUF4719 PF15843.5 ELR15751.1 - 4.3 7.4 5.4 13 5.8 0.4 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4719) C2 PF00168.30 ELR15752.1 - 2.2e-08 34.3 0.0 4.9e-08 33.2 0.0 1.6 1 0 0 1 1 1 1 C2 domain tRNA-synt_1e PF01406.19 ELR15752.1 - 0.026 13.9 0.3 0.039 13.3 0.3 1.2 1 0 0 1 1 1 0 tRNA synthetases class I (C) catalytic domain DUF3755 PF12579.8 ELR15752.1 - 0.13 11.9 0.7 0.3 10.8 0.7 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3755) RasGAP_C PF03836.15 ELR15752.1 - 2.6 8.2 12.2 0.36 11.0 7.8 1.8 2 0 0 2 2 2 0 RasGAP C-terminus GREB1 PF15782.5 ELR15752.1 - 4.2 4.4 6.0 0.19 8.8 0.6 1.4 2 0 0 2 2 2 0 Gene regulated by oestrogen in breast cancer DUF4487 PF14868.6 ELR15753.1 - 2.1e-18 66.5 4.1 1.2e-15 57.4 1.4 3.3 2 1 0 2 2 2 2 Domain of unknown function (DUF4487) zf-B_box PF00643.24 ELR15754.1 - 8.9e-09 35.4 18.4 7.1e-07 29.3 0.4 4.0 4 0 0 4 4 4 2 B-box zinc finger zf-RING_5 PF14634.6 ELR15754.1 - 6.5e-07 29.2 4.1 6.5e-07 29.2 4.1 3.4 3 3 0 3 3 3 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 ELR15754.1 - 6.8e-07 29.2 0.6 6.8e-07 29.2 0.6 2.5 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4 PF00097.25 ELR15754.1 - 6.4e-06 25.9 2.6 6.4e-06 25.9 2.6 3.7 3 2 1 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 ELR15754.1 - 7.9e-06 26.1 6.6 7.9e-06 26.1 6.6 3.9 2 2 1 3 3 3 1 Ring finger domain zf-C3HC4_2 PF13923.6 ELR15754.1 - 0.00024 20.9 1.9 0.00024 20.9 1.9 3.9 5 1 0 5 5 4 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 ELR15754.1 - 0.0065 16.6 1.8 0.0065 16.6 1.8 4.2 4 2 0 4 4 4 1 zinc finger of C3HC4-type, RING zf-RING_11 PF17123.5 ELR15754.1 - 0.034 13.9 2.9 0.034 13.9 2.9 2.7 2 0 0 2 2 2 0 RING-like zinc finger IBR PF01485.21 ELR15754.1 - 0.87 9.9 18.6 2 8.7 0.8 3.9 2 2 1 3 3 3 0 IBR domain, a half RING-finger domain FYVE PF01363.21 ELR15754.1 - 2.7 8.2 21.1 2.4e+03 -1.2 21.1 3.2 1 1 0 1 1 1 0 FYVE zinc finger zf-UBR PF02207.20 ELR15754.1 - 2.8 8.2 20.7 0.28 11.4 0.3 3.5 2 2 1 3 3 3 0 Putative zinc finger in N-recognin (UBR box) NHL PF01436.21 ELR15755.1 - 1.5e-26 91.1 10.4 2.9e-10 39.6 0.4 3.4 3 0 0 3 3 3 3 NHL repeat DUF5128 PF17170.4 ELR15755.1 - 1.4e-05 24.5 0.0 4.4e-05 22.8 0.0 1.7 1 1 1 2 2 2 2 6-bladed beta-propeller SGL PF08450.12 ELR15755.1 - 1.5e-05 24.7 4.3 0.024 14.2 0.1 3.0 1 1 1 3 3 3 2 SMP-30/Gluconolactonase/LRE-like region zf-B_box PF00643.24 ELR15755.1 - 0.0068 16.5 0.0 0.011 15.9 0.0 1.3 1 0 0 1 1 1 1 B-box zinc finger Sulfotransfer_4 PF17784.1 ELR15755.1 - 0.012 15.5 0.2 0.017 15.0 0.2 1.2 1 0 0 1 1 1 0 Sulfotransferase domain zf-UBR PF02207.20 ELR15755.1 - 0.064 13.4 0.0 0.14 12.4 0.0 1.6 1 0 0 1 1 1 0 Putative zinc finger in N-recognin (UBR box) DUF4082 PF13313.6 ELR15755.1 - 0.11 12.6 0.2 3.4 7.7 0.0 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4082) PQQ PF01011.21 ELR15755.1 - 0.11 12.4 0.1 11 6.2 0.0 2.6 2 0 0 2 2 2 0 PQQ enzyme repeat SdiA-regulated PF06977.11 ELR15755.1 - 0.16 11.2 0.0 0.29 10.3 0.0 1.4 1 0 0 1 1 1 0 SdiA-regulated TraC PF07820.12 ELR15755.1 - 5.4 7.4 15.1 8.9 6.7 10.6 2.2 1 1 1 2 2 2 0 TraC-like protein DnaJ PF00226.31 ELR15756.1 - 4.9e-20 71.4 0.1 8.1e-20 70.7 0.1 1.4 1 0 0 1 1 1 1 DnaJ domain zf-B_box PF00643.24 ELR15756.1 - 0.008 16.3 7.3 0.008 16.3 7.3 2.0 2 0 0 2 2 2 1 B-box zinc finger DUF2321 PF10083.9 ELR15756.1 - 0.08 12.6 0.4 0.16 11.6 0.4 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2321) ArfGap PF01412.18 ELR15756.1 - 0.15 12.2 1.0 0.27 11.3 1.0 1.4 1 0 0 1 1 1 0 Putative GTPase activating protein for Arf DUF647 PF04884.14 ELR15757.1 - 1.4e-40 139.4 0.3 1.8e-30 106.3 0.3 2.4 2 0 0 2 2 2 2 Vitamin B6 photo-protection and homoeostasis HOOK PF05622.12 ELR15758.1 - 2.3e-90 303.8 70.5 2.6e-90 303.6 70.5 1.0 1 0 0 1 1 1 1 HOOK protein CH PF00307.31 ELR15758.1 - 0.00027 21.1 0.8 0.0013 18.8 0.1 2.7 2 1 0 2 2 2 1 Calponin homology (CH) domain CH_2 PF06294.11 ELR15758.1 - 0.0025 17.9 0.1 0.0025 17.9 0.1 3.1 3 0 0 3 3 3 1 CH-like domain in sperm protein HALZ PF02183.18 ELR15758.1 - 0.02 15.1 2.7 0.02 15.1 2.7 6.2 5 0 0 5 5 5 0 Homeobox associated leucine zipper CAMSAP_CH PF11971.8 ELR15758.1 - 0.059 13.2 0.1 0.47 10.3 0.0 2.6 2 0 0 2 2 2 0 CAMSAP CH domain RCC1 PF00415.18 ELR15759.1 - 3.9e-38 129.8 6.9 8.9e-12 45.4 0.3 5.0 4 0 0 4 4 4 4 Regulator of chromosome condensation (RCC1) repeat BTB PF00651.31 ELR15759.1 - 2.5e-31 108.2 3.4 1.2e-23 83.4 0.2 3.8 2 1 1 3 3 3 2 BTB/POZ domain Filamin PF00630.19 ELR15759.1 - 4.8e-27 94.8 0.3 5.9e-08 33.5 0.0 4.1 3 1 0 3 3 3 3 Filamin/ABP280 repeat RCC1_2 PF13540.6 ELR15759.1 - 8.8e-14 50.9 19.8 3.1e-05 23.7 0.2 6.3 6 0 0 6 6 6 4 Regulator of chromosome condensation (RCC1) repeat Invasin_D3 PF09134.10 ELR15759.1 - 2.1e-06 28.0 0.9 0.041 14.2 0.1 4.6 3 1 0 3 3 3 2 Invasin, domain 3 SR-25 PF10500.9 ELR15759.1 - 0.0036 17.0 8.9 0.0036 17.0 8.9 7.5 8 1 0 8 8 8 1 Nuclear RNA-splicing-associated protein DUF3342 PF11822.8 ELR15759.1 - 0.14 12.4 0.0 0.34 11.1 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3342) DUF1754 PF08555.10 ELR15760.1 - 1.3e-09 38.8 19.4 2.1e-09 38.0 19.4 1.3 1 0 0 1 1 1 1 Eukaryotic family of unknown function (DUF1754) DUF2730 PF10805.8 ELR15760.1 - 0.034 14.2 0.1 0.055 13.6 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2730) Nop53 PF07767.11 ELR15760.1 - 0.16 11.3 25.8 0.19 11.1 25.8 1.0 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) Raftlin PF15250.6 ELR15760.1 - 0.22 10.2 7.6 0.26 10.0 7.6 1.0 1 0 0 1 1 1 0 Raftlin SpoIIIAH PF12685.7 ELR15760.1 - 1.4 8.7 9.7 1.9 8.3 9.7 1.1 1 0 0 1 1 1 0 SpoIIIAH-like protein NARP1 PF12569.8 ELR15760.1 - 2.4 7.0 15.0 2.9 6.7 15.0 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 SRP-alpha_N PF04086.13 ELR15760.1 - 3.9 7.3 17.0 4.7 7.0 17.0 1.1 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal Presenilin PF01080.17 ELR15760.1 - 4.4 6.0 11.9 5.2 5.7 11.9 1.0 1 0 0 1 1 1 0 Presenilin RR_TM4-6 PF06459.12 ELR15760.1 - 4.5 7.0 14.1 5.8 6.6 14.1 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 SLC12 PF03522.15 ELR15760.1 - 8.4 5.3 7.0 9.7 5.1 7.0 1.0 1 0 0 1 1 1 0 Solute carrier family 12 Spore_coat_CotO PF14153.6 ELR15760.1 - 8.5 6.3 19.0 10 6.0 18.5 1.3 1 1 0 1 1 1 0 Spore coat protein CotO Astro_capsid_p PF12226.8 ELR15760.1 - 8.9 5.4 10.7 13 4.9 10.7 1.2 1 0 0 1 1 1 0 Turkey astrovirus capsid protein F-box-like PF12937.7 ELR15761.1 - 3.1e-15 55.8 3.2 3.1e-15 55.8 3.2 2.1 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 ELR15761.1 - 2.7e-06 27.1 5.8 3.2e-06 26.9 1.9 3.0 2 0 0 2 2 2 1 F-box domain LRR_4 PF12799.7 ELR15761.1 - 1.6e-05 25.2 0.2 0.29 11.6 0.1 5.3 5 0 0 5 5 5 1 Leucine Rich repeats (2 copies) zf-MYND PF01753.18 ELR15761.1 - 0.0066 16.5 2.0 0.0066 16.5 2.0 2.2 2 0 0 2 2 2 1 MYND finger LRR_8 PF13855.6 ELR15761.1 - 0.028 14.2 3.5 0.34 10.7 0.2 3.9 4 0 0 4 4 4 0 Leucine rich repeat NOA36 PF06524.12 ELR15761.1 - 1.5 8.1 6.7 0.49 9.7 0.9 2.3 2 0 0 2 2 2 0 NOA36 protein LRR_6 PF13516.6 ELR15761.1 - 1.9 8.7 7.5 84 3.6 0.1 5.7 6 0 0 6 6 6 0 Leucine Rich repeat PBP1_TM PF14812.6 ELR15761.1 - 3.9 7.9 13.3 0.15 12.4 4.3 2.3 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal YugN PF08868.10 ELR15762.1 - 0.094 12.6 0.0 0.13 12.2 0.0 1.2 1 0 0 1 1 1 0 YugN-like family Glyco_hydro_16 PF00722.21 ELR15763.1 - 3.9e-09 36.2 0.0 8e-09 35.2 0.0 1.6 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 F-box-like PF12937.7 ELR15764.1 - 3.4e-05 23.7 0.0 7.6e-05 22.5 0.0 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ELR15764.1 - 0.1 12.5 0.2 0.33 10.9 0.2 1.9 1 0 0 1 1 1 0 F-box domain SR-25 PF10500.9 ELR15765.1 - 0.21 11.2 3.9 0.26 10.9 3.9 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein NHL PF01436.21 ELR15768.1 - 1.2e-53 176.5 27.4 2.5e-11 43.0 0.4 6.5 6 0 0 6 6 6 6 NHL repeat DUF5128 PF17170.4 ELR15768.1 - 1.9e-20 73.3 0.0 1.9e-07 30.5 0.0 3.8 1 1 3 4 4 4 4 6-bladed beta-propeller zf-B_box PF00643.24 ELR15768.1 - 2.7e-09 37.0 20.5 1.2e-06 28.5 0.4 4.0 4 0 0 4 4 4 2 B-box zinc finger SGL PF08450.12 ELR15768.1 - 9.3e-08 31.9 14.4 0.013 15.1 0.4 5.2 2 1 3 5 5 5 3 SMP-30/Gluconolactonase/LRE-like region zf-RING_5 PF14634.6 ELR15768.1 - 5.6e-07 29.4 3.6 5.6e-07 29.4 3.6 3.0 3 0 0 3 3 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 ELR15768.1 - 4.4e-06 26.6 2.2 4.4e-06 26.6 2.2 2.7 3 0 0 3 3 2 1 RING-type zinc-finger zf-RING_2 PF13639.6 ELR15768.1 - 1.4e-05 25.3 7.9 1.4e-05 25.3 7.9 4.0 4 1 0 4 4 3 1 Ring finger domain zf-C3HC4 PF00097.25 ELR15768.1 - 4.5e-05 23.2 3.2 4.5e-05 23.2 3.2 3.1 2 1 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 ELR15768.1 - 0.00063 19.5 1.9 0.00063 19.5 1.9 3.3 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) FYVE PF01363.21 ELR15768.1 - 0.0011 19.0 1.7 0.0011 19.0 1.7 3.1 3 1 0 3 3 3 1 FYVE zinc finger Arylesterase PF01731.20 ELR15768.1 - 0.0016 18.6 0.0 12 6.2 0.0 4.5 5 0 0 5 5 5 0 Arylesterase TolB_like PF15869.5 ELR15768.1 - 0.0046 16.2 0.0 0.58 9.3 0.0 2.9 1 1 3 4 4 4 1 TolB-like 6-blade propeller-like zf-C3HC4_4 PF15227.6 ELR15768.1 - 0.0092 16.1 1.4 0.0092 16.1 1.4 4.1 4 1 0 4 4 3 1 zinc finger of C3HC4-type, RING Baculo_IE-1 PF05290.11 ELR15768.1 - 0.12 12.3 2.1 4.6 7.2 0.3 2.4 2 0 0 2 2 2 0 Baculovirus immediate-early protein (IE-0) zf-C3HC4_3 PF13920.6 ELR15768.1 - 1.6 8.7 25.5 1.1 9.2 8.5 4.0 3 1 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) ERM PF00769.19 ELR15768.1 - 5.2 6.8 16.7 8.3 6.1 16.7 1.2 1 0 0 1 1 1 0 Ezrin/radixin/moesin family COG2 PF06148.11 ELR15769.1 - 0.25 11.4 3.4 0.39 10.8 2.1 2.0 1 1 0 1 1 1 0 COG (conserved oligomeric Golgi) complex component, COG2 ATG16 PF08614.11 ELR15769.1 - 0.39 10.9 17.5 0.1 12.8 11.5 2.0 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) SKA2 PF16740.5 ELR15769.1 - 0.66 9.8 8.2 1.8 8.4 8.2 1.7 1 1 0 1 1 1 0 Spindle and kinetochore-associated protein 2 CorA PF01544.18 ELR15769.1 - 0.96 8.7 5.2 0.14 11.4 1.6 1.4 2 0 0 2 2 2 0 CorA-like Mg2+ transporter protein DUF5364 PF17322.2 ELR15769.1 - 1.9 8.7 9.4 0.1 12.9 4.2 1.5 2 0 0 2 2 2 0 Family of unknown function (DUF5364) EF-hand_7 PF13499.6 ELR15770.1 - 1.1e-06 28.9 0.7 0.0045 17.4 0.1 2.6 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 ELR15770.1 - 0.00028 20.7 0.3 0.0082 16.0 0.1 2.5 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.6 ELR15770.1 - 0.0022 17.8 1.7 1.1 9.4 0.0 2.9 2 0 0 2 2 2 1 EF-hand domain EF-hand_1 PF00036.32 ELR15770.1 - 0.0022 17.4 1.3 0.71 9.6 0.3 2.8 2 0 0 2 2 2 1 EF hand DUF4201 PF13870.6 ELR15770.1 - 0.0062 16.3 7.4 0.011 15.5 7.4 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4201) Mce4_CUP1 PF11887.8 ELR15770.1 - 0.0062 16.0 0.4 0.0062 16.0 0.4 2.1 2 1 1 3 3 3 1 Cholesterol uptake porter CUP1 of Mce4, putative ATG16 PF08614.11 ELR15770.1 - 0.0071 16.6 18.8 0.0071 16.6 18.8 1.8 2 1 0 2 2 1 1 Autophagy protein 16 (ATG16) Med9 PF07544.13 ELR15770.1 - 0.011 15.8 3.7 0.057 13.5 3.7 2.3 1 1 0 1 1 1 0 RNA polymerase II transcription mediator complex subunit 9 TMCO5 PF14992.6 ELR15770.1 - 0.031 13.9 3.9 0.042 13.4 3.9 1.2 1 0 0 1 1 1 0 TMCO5 family Spc7 PF08317.11 ELR15770.1 - 0.031 13.2 14.7 0.045 12.6 14.1 1.5 1 1 0 1 1 1 0 Spc7 kinetochore protein Macoilin PF09726.9 ELR15770.1 - 0.056 12.0 7.2 0.059 11.9 7.2 1.1 1 0 0 1 1 1 0 Macoilin family TLE_N PF03920.15 ELR15770.1 - 0.067 13.3 1.0 0.13 12.3 1.0 1.5 1 0 0 1 1 1 0 Groucho/TLE N-terminal Q-rich domain GldM_N PF12081.8 ELR15770.1 - 0.077 13.1 5.7 1.1 9.3 5.7 2.1 1 1 0 1 1 1 0 GldM N-terminal domain DUF724 PF05266.14 ELR15770.1 - 0.087 12.6 9.0 0.14 12.0 9.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF724) ADIP PF11559.8 ELR15770.1 - 0.15 12.1 12.6 1.4 9.0 5.9 2.3 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding GAS PF13851.6 ELR15770.1 - 0.16 11.3 11.8 0.054 12.8 3.3 2.3 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding DUF4200 PF13863.6 ELR15770.1 - 0.2 12.0 11.8 0.063 13.7 5.8 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) APG6_N PF17675.1 ELR15770.1 - 0.27 11.8 20.3 1.3 9.6 4.1 2.4 1 1 1 2 2 2 0 Apg6 coiled-coil region FlaC_arch PF05377.11 ELR15770.1 - 0.44 11.0 5.0 0.82 10.1 0.6 2.9 1 1 1 2 2 2 0 Flagella accessory protein C (FlaC) WXG100 PF06013.12 ELR15770.1 - 0.45 10.8 8.1 10 6.5 0.0 3.4 2 1 1 3 3 3 0 Proteins of 100 residues with WXG AAA_13 PF13166.6 ELR15770.1 - 0.49 9.0 8.5 0.64 8.6 8.5 1.1 1 0 0 1 1 1 0 AAA domain UPF0242 PF06785.11 ELR15770.1 - 0.5 10.5 12.1 1.7 8.7 12.0 1.9 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus DUF4407 PF14362.6 ELR15770.1 - 0.55 9.5 8.4 0.67 9.3 8.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) SlyX PF04102.12 ELR15770.1 - 1.1 10.0 11.2 0.69 10.6 4.2 2.9 2 1 1 3 3 3 0 SlyX DivIC PF04977.15 ELR15770.1 - 2.6 7.9 10.8 2.6 7.9 1.7 2.4 1 1 0 2 2 2 0 Septum formation initiator HAUS-augmin3 PF14932.6 ELR15770.1 - 3.8 7.0 14.5 3.1 7.3 8.2 2.2 1 1 1 2 2 2 0 HAUS augmin-like complex subunit 3 KxDL PF10241.9 ELR15770.1 - 4.8 7.5 10.5 3.5 8.0 2.1 2.8 2 1 1 3 3 3 0 Uncharacterized conserved protein YabA PF06156.13 ELR15770.1 - 5.4 7.7 7.6 9.4 6.9 1.0 2.5 1 1 1 2 2 2 0 Initiation control protein YabA Beach PF02138.18 ELR15772.1 - 1.1e-97 326.7 0.0 2.4e-97 325.6 0.0 1.4 1 1 0 1 1 1 1 Beige/BEACH domain WD40 PF00400.32 ELR15772.1 - 0.0011 19.7 2.4 0.024 15.5 0.4 2.7 2 0 0 2 2 2 1 WD domain, G-beta repeat Nucleoporin_N PF08801.11 ELR15772.1 - 0.0084 14.9 0.0 0.026 13.3 0.1 1.7 2 0 0 2 2 2 1 Nup133 N terminal like WD40_like PF17005.5 ELR15772.1 - 0.029 13.7 0.0 0.043 13.1 0.0 1.1 1 0 0 1 1 1 0 WD40-like domain Nup160 PF11715.8 ELR15772.1 - 0.04 12.6 0.2 0.062 11.9 0.2 1.2 1 0 0 1 1 1 0 Nucleoporin Nup120/160 MCR_C PF04609.12 ELR15772.1 - 0.044 12.9 0.0 0.069 12.2 0.0 1.2 1 0 0 1 1 1 0 Methyl-coenzyme M reductase operon protein C CBFD_NFYB_HMF PF00808.23 ELR15773.1 - 1.6e-07 31.5 0.2 2.8e-07 30.7 0.2 1.4 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Glyco_hydro_3_C PF01915.22 ELR15774.1 - 2.8e-42 145.0 0.1 3.6e-42 144.6 0.1 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Fn3-like PF14310.6 ELR15774.1 - 1.3e-11 44.4 0.1 2.1e-11 43.7 0.1 1.3 1 0 0 1 1 1 1 Fibronectin type III-like domain Ldh_1_N PF00056.23 ELR15774.1 - 0.00072 19.7 0.1 0.0011 19.1 0.1 1.2 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain HA2 PF04408.23 ELR15775.1 - 1.6e-20 73.4 0.0 4.5e-20 71.9 0.0 1.8 1 0 0 1 1 1 1 Helicase associated domain (HA2) Helicase_C PF00271.31 ELR15775.1 - 3.3e-11 43.5 0.0 1.2e-10 41.7 0.0 2.0 1 0 0 1 1 1 1 Helicase conserved C-terminal domain OB_NTP_bind PF07717.16 ELR15775.1 - 6.3e-11 42.5 0.1 1.9e-10 41.0 0.1 1.8 1 1 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold DEAD PF00270.29 ELR15775.1 - 0.023 14.5 0.1 0.046 13.5 0.1 1.5 1 0 0 1 1 1 0 DEAD/DEAH box helicase DNA_pol3_delta PF06144.13 ELR15775.1 - 0.1 12.3 0.1 0.62 9.8 0.0 2.1 1 1 1 2 2 2 0 DNA polymerase III, delta subunit Pkinase_Tyr PF07714.17 ELR15776.1 - 2.6e-38 131.8 0.0 3.6e-38 131.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ELR15776.1 - 1.4e-35 122.9 0.0 2e-35 122.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Ank_4 PF13637.6 ELR15776.1 - 0.096 13.3 0.0 0.61 10.7 0.1 2.3 2 0 0 2 2 2 0 Ankyrin repeats (many copies) DUF2722 PF10846.8 ELR15776.1 - 0.18 10.7 6.5 0.23 10.3 6.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) CDC45 PF02724.14 ELR15776.1 - 0.4 8.9 4.8 0.53 8.5 4.8 1.1 1 0 0 1 1 1 0 CDC45-like protein Spt5_N PF11942.8 ELR15776.1 - 0.77 10.8 11.0 1.1 10.2 11.0 1.2 1 0 0 1 1 1 0 Spt5 transcription elongation factor, acidic N-terminal MULE PF10551.9 ELR15777.1 - 3.9e-12 46.4 0.0 1.5e-11 44.6 0.0 2.0 2 0 0 2 2 2 1 MULE transposase domain SWIM PF04434.17 ELR15777.1 - 1.8e-06 27.5 0.5 3.8e-06 26.4 0.5 1.5 1 0 0 1 1 1 1 SWIM zinc finger TFIIA PF03153.13 ELR15777.1 - 0.0049 16.9 0.4 0.0072 16.4 0.4 1.3 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit zf-primase PF09329.11 ELR15777.1 - 0.018 14.9 0.1 1.8 8.4 0.0 2.6 2 0 0 2 2 2 0 Primase zinc finger FAM176 PF14851.6 ELR15777.1 - 2.5 7.8 6.3 9.7 5.8 4.2 2.5 3 0 0 3 3 3 0 FAM176 family DNA_pol_phi PF04931.13 ELR15777.1 - 2.7 6.0 7.2 4.3 5.3 7.2 1.2 1 0 0 1 1 1 0 DNA polymerase phi UPRTase PF14681.6 ELR15779.1 - 1.4e-79 266.4 0.0 1.7e-79 266.1 0.0 1.1 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase Pribosyltran PF00156.27 ELR15779.1 - 3.6e-06 26.6 0.0 7.5e-06 25.5 0.0 1.5 1 1 0 1 1 1 1 Phosphoribosyl transferase domain Zip PF02535.22 ELR15781.1 - 9.6e-07 28.3 5.2 0.0027 17.0 0.1 2.1 2 0 0 2 2 2 2 ZIP Zinc transporter COesterase PF00135.28 ELR15784.1 - 1.1e-80 271.9 0.0 2.7e-71 241.0 0.0 2.0 1 1 1 2 2 2 2 Carboxylesterase family Abhydrolase_3 PF07859.13 ELR15784.1 - 3.4e-07 30.3 0.1 0.00056 19.8 0.1 2.3 2 0 0 2 2 2 2 alpha/beta hydrolase fold Pkinase_Tyr PF07714.17 ELR15785.1 - 3.5e-115 383.7 0.0 1.4e-59 201.5 0.0 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 ELR15785.1 - 3.4e-98 328.2 0.0 7.2e-48 163.2 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain PBP_like_2 PF12849.7 ELR15785.1 - 2.8e-27 96.1 7.8 9.7e-16 58.3 0.1 2.3 2 0 0 2 2 2 2 PBP superfamily domain Pkinase_fungal PF17667.1 ELR15785.1 - 9.8e-07 27.9 0.0 0.0089 14.8 0.0 2.2 2 0 0 2 2 2 2 Fungal protein kinase Kinase-like PF14531.6 ELR15785.1 - 2.6e-06 27.0 0.0 0.017 14.5 0.0 2.4 2 0 0 2 2 2 2 Kinase-like EGF_2 PF07974.13 ELR15785.1 - 0.00047 20.5 9.1 0.0011 19.3 9.1 1.7 1 0 0 1 1 1 1 EGF-like domain Kdo PF06293.14 ELR15785.1 - 0.0081 15.5 0.1 1.1 8.6 0.1 2.2 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family EGF PF00008.27 ELR15785.1 - 0.01 16.1 4.2 0.028 14.7 4.2 1.8 1 0 0 1 1 1 0 EGF-like domain SKG6 PF08693.10 ELR15785.1 - 0.055 12.9 3.4 0.13 11.7 3.4 1.6 1 0 0 1 1 1 0 Transmembrane alpha-helix domain APH PF01636.23 ELR15785.1 - 0.17 11.7 14.1 0.42 10.5 0.3 4.6 3 2 2 5 5 5 0 Phosphotransferase enzyme family hEGF PF12661.7 ELR15785.1 - 0.5 11.1 5.3 1.5 9.5 5.3 1.9 1 0 0 1 1 1 0 Human growth factor-like EGF Laminin_EGF PF00053.24 ELR15785.1 - 0.83 9.9 5.6 2.1 8.6 5.6 1.7 1 0 0 1 1 1 0 Laminin EGF domain Pkinase_Tyr PF07714.17 ELR15786.1 - 1.2e-122 408.2 0.0 5.2e-67 225.9 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 ELR15786.1 - 1.8e-103 345.5 0.0 8.5e-57 192.5 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Haspin_kinase PF12330.8 ELR15786.1 - 3.6e-11 42.6 0.0 0.00078 18.5 0.0 3.5 3 1 0 3 3 3 2 Haspin like kinase domain APH PF01636.23 ELR15786.1 - 1.3e-08 35.1 3.9 0.0036 17.2 0.0 4.0 4 1 0 5 5 5 2 Phosphotransferase enzyme family FHA_2 PF17913.1 ELR15786.1 - 4.4e-07 30.0 0.0 1.1e-06 28.8 0.0 1.6 1 0 0 1 1 1 1 FHA domain Kinase-like PF14531.6 ELR15786.1 - 3.4e-06 26.6 0.1 0.066 12.5 0.0 2.5 3 0 0 3 3 3 2 Kinase-like FHA PF00498.26 ELR15786.1 - 0.0018 18.5 0.0 0.0042 17.4 0.0 1.7 1 0 0 1 1 1 1 FHA domain ABC1 PF03109.16 ELR15786.1 - 0.0075 16.4 0.0 3.9 7.7 0.0 2.6 2 0 0 2 2 2 1 ABC1 family RIO1 PF01163.22 ELR15786.1 - 0.0093 15.6 0.2 1.1 8.8 0.0 2.6 2 1 0 2 2 2 1 RIO1 family FTA2 PF13095.6 ELR15786.1 - 0.01 15.5 0.0 0.2 11.3 0.0 2.3 2 0 0 2 2 2 1 Kinetochore Sim4 complex subunit FTA2 Seadorna_VP7 PF07387.11 ELR15786.1 - 0.041 12.9 0.2 6.3 5.7 0.1 2.4 2 0 0 2 2 2 0 Seadornavirus VP7 Yop-YscD_cpl PF16697.5 ELR15786.1 - 0.078 13.3 0.0 0.21 11.9 0.0 1.7 1 0 0 1 1 1 0 Inner membrane component of T3SS, cytoplasmic domain Kdo PF06293.14 ELR15786.1 - 0.18 11.1 0.0 8.6 5.6 0.0 2.4 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family DUF3746 PF12562.8 ELR15786.1 - 0.3 11.0 1.3 12 5.9 0.1 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3746) TMEM72 PF16054.5 ELR15787.1 - 0.65 9.7 3.4 1 9.1 3.4 1.3 1 0 0 1 1 1 0 Transmembrane protein family 72 DUF4229 PF14012.6 ELR15787.1 - 2.5 8.3 9.7 0.058 13.5 2.5 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF4229) DUF5320 PF17253.2 ELR15788.1 - 0.00024 22.1 4.5 0.00069 20.6 0.4 2.5 2 0 0 2 2 2 1 Family of unknown function (DUF5320) Tim17 PF02466.19 ELR15788.1 - 0.059 13.8 6.6 0.15 12.4 6.6 1.8 1 1 0 1 1 1 0 Tim17/Tim22/Tim23/Pmp24 family CSG2 PF16965.5 ELR15788.1 - 6.2 5.7 5.9 9.6 5.0 0.1 2.1 1 1 1 2 2 2 0 Ceramide synthase regulator UPRTase PF14681.6 ELR15789.1 - 6.6e-62 208.6 0.0 8.8e-62 208.2 0.0 1.1 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase Pribosyltran PF00156.27 ELR15789.1 - 0.0069 15.9 0.0 0.015 14.8 0.0 1.5 1 1 0 1 1 1 1 Phosphoribosyl transferase domain START PF01852.19 ELR15790.1 - 5.7e-13 48.8 0.0 8.2e-13 48.2 0.0 1.2 1 0 0 1 1 1 1 START domain PUMA PF15826.5 ELR15790.1 - 0.041 14.1 0.2 0.075 13.2 0.2 1.3 1 0 0 1 1 1 0 Bcl-2-binding component 3, p53 upregulated modulator of apoptosis START PF01852.19 ELR15791.1 - 2.7e-13 49.8 0.0 3.1e-13 49.6 0.0 1.1 1 0 0 1 1 1 1 START domain Methyltransf_5 PF01795.19 ELR15792.1 - 4.9e-79 266.0 0.0 7.9e-79 265.4 0.0 1.2 1 0 0 1 1 1 1 MraW methylase family ubiquitin PF00240.23 ELR15792.1 - 3.5e-17 61.9 0.0 1e-16 60.4 0.0 1.9 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 ELR15792.1 - 0.00049 19.9 0.0 0.0016 18.3 0.0 1.9 2 0 0 2 2 2 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 ELR15792.1 - 0.0059 17.0 0.0 0.016 15.6 0.0 1.8 1 0 0 1 1 1 1 Ubiquitin-like domain RNA_pol_3_Rpc31 PF11705.8 ELR15792.1 - 0.0086 16.4 2.9 0.0086 16.4 2.9 3.8 3 0 0 3 3 3 1 DNA-directed RNA polymerase III subunit Rpc31 DUF2407 PF10302.9 ELR15792.1 - 0.14 12.7 0.7 0.61 10.7 0.0 2.4 2 0 0 2 2 2 0 DUF2407 ubiquitin-like domain Sec1 PF00995.23 ELR15793.1 - 1.2e-114 384.6 0.1 2.1e-114 383.8 0.1 1.4 1 1 0 1 1 1 1 Sec1 family UPF0020 PF01170.18 ELR15794.1 - 1.7e-32 112.7 0.0 9.1e-32 110.3 0.0 1.9 1 1 0 1 1 1 1 Putative RNA methylase family UPF0020 Methyltransf_25 PF13649.6 ELR15794.1 - 1.5e-11 44.8 0.0 3.6e-11 43.6 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ELR15794.1 - 1.9e-09 38.1 0.0 4.7e-09 36.8 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ELR15794.1 - 2.3e-08 34.0 0.0 3.8e-08 33.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain AviRa PF11599.8 ELR15794.1 - 4.9e-08 32.7 0.1 3.1e-06 26.8 0.0 2.5 2 1 1 3 3 3 1 RRNA methyltransferase AviRa Methyltransf_4 PF02390.17 ELR15794.1 - 4.2e-05 23.1 0.0 7.7e-05 22.2 0.0 1.4 1 0 0 1 1 1 1 Putative methyltransferase Ubie_methyltran PF01209.18 ELR15794.1 - 7.6e-05 22.2 0.0 0.00012 21.5 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family MTS PF05175.14 ELR15794.1 - 0.0019 17.8 0.0 0.0035 16.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain THUMP PF02926.17 ELR15794.1 - 0.0079 16.3 0.0 0.016 15.3 0.0 1.5 1 0 0 1 1 1 1 THUMP domain N6_Mtase PF02384.16 ELR15794.1 - 0.069 12.4 0.0 0.1 11.8 0.0 1.2 1 0 0 1 1 1 0 N-6 DNA Methylase F-box-like PF12937.7 ELR15795.1 - 3.3e-06 26.9 1.3 9.8e-06 25.4 1.3 1.9 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ELR15795.1 - 7.6e-05 22.5 0.3 0.0002 21.1 0.3 1.7 1 0 0 1 1 1 1 F-box domain MarR_2 PF12802.7 ELR15795.1 - 0.0034 17.3 3.6 0.026 14.4 0.0 3.4 3 0 0 3 3 3 1 MarR family Ras PF00071.22 ELR15796.1 - 8.1e-33 113.3 0.0 9.3e-33 113.1 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR15796.1 - 1.5e-07 31.6 0.0 2.3e-07 31.0 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR15796.1 - 0.037 13.5 0.0 0.053 13.0 0.0 1.3 1 1 0 1 1 1 0 ADP-ribosylation factor family PI3_PI4_kinase PF00454.27 ELR15797.1 - 5.1e-58 196.8 0.0 4e-57 193.9 0.0 2.2 1 1 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase PI3Ka PF00613.20 ELR15797.1 - 4.3e-38 130.6 1.1 1e-22 80.4 0.0 2.8 2 1 1 3 3 3 2 Phosphoinositide 3-kinase family, accessory domain (PIK domain) PI3K_C2 PF00792.24 ELR15797.1 - 1.3e-23 83.4 0.0 2.7e-23 82.4 0.0 1.5 1 0 0 1 1 1 1 Phosphoinositide 3-kinase C2 PI3K_rbd PF00794.18 ELR15797.1 - 1.2e-19 70.5 0.0 3e-14 53.1 0.0 2.6 2 0 0 2 2 2 2 PI3-kinase family, ras-binding domain C2 PF00168.30 ELR15797.1 - 0.0045 17.3 0.0 0.012 15.9 0.0 1.7 2 0 0 2 2 2 1 C2 domain DUF4135 PF13575.6 ELR15797.1 - 0.0075 15.6 0.0 0.013 14.9 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4135) SR-25 PF10500.9 ELR15797.1 - 0.011 15.4 7.0 0.024 14.3 7.0 1.5 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein PI3K_p85B PF02192.16 ELR15797.1 - 0.021 14.6 0.0 0.18 11.6 0.0 2.4 2 0 0 2 2 2 0 PI3-kinase family, p85-binding domain Rad60-SLD_2 PF13881.6 ELR15797.1 - 0.11 12.6 0.0 9 6.5 0.0 2.6 2 0 0 2 2 2 0 Ubiquitin-2 like Rad60 SUMO-like Mito_carr PF00153.27 ELR15799.1 - 7.5e-44 147.6 0.6 7.8e-16 57.8 0.0 3.3 3 0 0 3 3 3 3 Mitochondrial carrier protein OmdA PF13376.6 ELR15800.1 - 1.3e-05 25.1 7.6 0.00037 20.4 3.0 3.1 2 1 1 3 3 3 2 Bacteriocin-protection, YdeI or OmpD-Associated NHL PF01436.21 ELR15801.1 - 7.8e-32 107.7 18.3 7.6e-09 35.2 0.5 5.3 5 0 0 5 5 5 4 NHL repeat zf-B_box PF00643.24 ELR15801.1 - 1.6e-10 40.9 24.9 4.9e-08 33.0 0.2 4.2 5 0 0 5 5 4 2 B-box zinc finger zf-RING_5 PF14634.6 ELR15801.1 - 1.6e-07 31.2 3.2 1.6e-07 31.2 3.2 3.9 4 1 0 4 4 3 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 ELR15801.1 - 9.1e-06 25.6 2.5 9.1e-06 25.6 2.5 3.3 4 0 0 4 4 3 1 RING-type zinc-finger zf-RING_2 PF13639.6 ELR15801.1 - 1.5e-05 25.2 6.1 1.5e-05 25.2 6.1 3.8 4 1 0 4 4 4 1 Ring finger domain zf-C3HC4 PF00097.25 ELR15801.1 - 2.3e-05 24.2 1.9 2.3e-05 24.2 1.9 4.0 4 1 0 4 4 3 1 Zinc finger, C3HC4 type (RING finger) SGL PF08450.12 ELR15801.1 - 4.8e-05 23.1 7.5 0.71 9.4 0.1 4.0 1 1 3 4 4 4 3 SMP-30/Gluconolactonase/LRE-like region DUF5128 PF17170.4 ELR15801.1 - 0.00017 20.8 0.0 0.077 12.1 0.0 2.1 1 1 1 2 2 2 2 6-bladed beta-propeller zf-C3HC4_2 PF13923.6 ELR15801.1 - 0.0032 17.3 1.6 0.0032 17.3 1.6 4.1 4 1 0 4 4 3 1 Zinc finger, C3HC4 type (RING finger) FYVE PF01363.21 ELR15801.1 - 0.0034 17.5 1.5 0.0034 17.5 1.5 3.5 3 1 0 3 3 2 1 FYVE zinc finger T3SS_TC PF06511.11 ELR15801.1 - 0.05 13.0 2.2 0.086 12.2 2.2 1.3 1 0 0 1 1 1 0 Type III secretion systems tip complex components Cys_rich_KTR PF14205.6 ELR15801.1 - 0.079 12.8 0.0 0.2 11.5 0.0 1.6 1 0 0 1 1 1 0 Cysteine-rich KTR Atg14 PF10186.9 ELR15801.1 - 0.3 10.1 1.6 0.52 9.3 1.6 1.4 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Herpes_UL25 PF01499.16 ELR15801.1 - 2.8 6.3 7.0 4.5 5.7 7.0 1.3 1 0 0 1 1 1 0 Herpesvirus UL25 family zf-C4H2 PF10146.9 ELR15801.1 - 2.9 8.1 5.6 21 5.3 0.6 2.3 2 0 0 2 2 2 0 Zinc finger-containing protein OmpH PF03938.14 ELR15801.1 - 7.4 6.9 8.2 17 5.8 8.2 1.6 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) zf-RING_2 PF13639.6 ELR15803.1 - 4.6e-09 36.5 8.3 4.6e-09 36.5 8.3 2.5 2 1 0 2 2 2 1 Ring finger domain zf-RING_UBOX PF13445.6 ELR15803.1 - 8e-09 35.4 5.5 8e-09 35.4 5.5 2.8 2 1 0 2 2 1 1 RING-type zinc-finger zf-C3HC4 PF00097.25 ELR15803.1 - 1.8e-08 34.1 8.6 1.8e-08 34.1 8.6 2.6 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ELR15803.1 - 1.1e-07 31.6 8.4 1.1e-07 31.6 8.4 2.8 2 1 0 2 2 2 1 zinc-RING finger domain zf-C3HC4_4 PF15227.6 ELR15803.1 - 1.8e-05 24.8 9.3 1.8e-05 24.8 9.3 2.8 2 1 1 3 3 3 1 zinc finger of C3HC4-type, RING zf-C3HC4_2 PF13923.6 ELR15803.1 - 4.8e-05 23.1 9.6 4.8e-05 23.1 9.6 2.9 2 1 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-B_box PF00643.24 ELR15803.1 - 0.00011 22.3 6.4 0.00011 22.3 6.4 3.8 4 0 0 4 4 4 1 B-box zinc finger zf-RING_11 PF17123.5 ELR15803.1 - 0.00033 20.3 1.4 0.00033 20.3 1.4 2.8 2 1 1 3 3 2 1 RING-like zinc finger zf-RING_4 PF14570.6 ELR15803.1 - 0.001 18.8 6.2 0.001 18.8 6.2 2.6 2 1 0 2 2 1 1 RING/Ubox like zinc-binding domain Baculo_IE-1 PF05290.11 ELR15803.1 - 0.0018 18.3 1.3 0.0018 18.3 1.3 2.0 2 0 0 2 2 2 1 Baculovirus immediate-early protein (IE-0) FYVE PF01363.21 ELR15803.1 - 0.46 10.6 20.0 1.2 9.3 7.8 3.1 1 1 1 2 2 2 0 FYVE zinc finger Prok-RING_4 PF14447.6 ELR15803.1 - 1.9 8.4 23.7 0.04 13.8 7.9 2.5 2 1 0 2 2 2 0 Prokaryotic RING finger family 4 Rtf2 PF04641.12 ELR15803.1 - 9.3 5.5 7.5 2.3 7.5 2.7 1.9 2 0 0 2 2 2 0 Rtf2 RING-finger PQ-loop PF04193.14 ELR15804.1 - 2.9e-24 84.6 7.1 6.5e-13 48.3 0.3 2.5 2 0 0 2 2 2 2 PQ loop repeat S1FA PF04689.13 ELR15804.1 - 0.088 13.0 0.2 0.21 11.7 0.2 1.6 1 0 0 1 1 1 0 DNA binding protein S1FA HATPase_c PF02518.26 ELR15805.1 - 4.4e-32 110.9 0.0 8.9e-32 109.9 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 ELR15805.1 - 1.6e-16 60.1 0.1 1.6e-16 60.1 0.1 2.0 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain Response_reg PF00072.24 ELR15805.1 - 1.2e-15 57.7 0.1 2.2e-14 53.6 0.1 2.5 1 1 0 1 1 1 1 Response regulator receiver domain MCU PF04678.13 ELR15805.1 - 1.3 9.1 4.5 15 5.7 3.9 2.5 2 0 0 2 2 2 0 Mitochondrial calcium uniporter LRR_4 PF12799.7 ELR15806.1 - 0.17 12.3 0.0 10 6.7 0.1 3.6 3 1 1 4 4 4 0 Leucine Rich repeats (2 copies) SelB-wing_2 PF09106.11 ELR15807.1 - 0.88 9.8 6.4 13 6.1 0.1 3.9 4 0 0 4 4 4 0 Elongation factor SelB, winged helix RRM_1 PF00076.22 ELR15808.1 - 6.9e-15 54.6 0.0 2.3e-05 24.1 0.0 3.6 3 1 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 ELR15808.1 - 0.082 13.0 0.0 5.1 7.2 0.0 2.3 2 0 0 2 2 2 0 RNA binding motif RRM_5 PF13893.6 ELR15808.1 - 0.25 10.9 0.0 0.67 9.6 0.0 1.7 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RFX_DNA_binding PF02257.15 ELR15809.1 - 2.7e-06 27.9 0.0 3.9e-06 27.4 0.0 1.2 1 0 0 1 1 1 1 RFX DNA-binding domain AMP-binding PF00501.28 ELR15810.1 - 4.1e-62 210.2 0.0 3.6e-60 203.7 0.0 2.3 1 1 0 1 1 1 1 AMP-binding enzyme NAD_binding_4 PF07993.12 ELR15810.1 - 5.6e-62 209.2 0.0 8.5e-62 208.6 0.0 1.3 1 0 0 1 1 1 1 Male sterility protein Epimerase PF01370.21 ELR15810.1 - 7.2e-15 55.1 0.0 1.4e-14 54.2 0.0 1.4 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 ELR15810.1 - 4.3e-06 25.9 0.0 1e-05 24.7 0.0 1.6 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family GDP_Man_Dehyd PF16363.5 ELR15810.1 - 5.5e-05 22.7 0.9 0.00015 21.3 0.0 2.1 2 1 0 2 2 2 1 GDP-mannose 4,6 dehydratase ZZ PF00569.17 ELR15810.1 - 0.00011 21.9 10.2 0.00012 21.8 7.1 2.3 2 0 0 2 2 2 1 Zinc finger, ZZ type RmlD_sub_bind PF04321.17 ELR15810.1 - 0.0018 17.5 0.0 0.0085 15.2 0.0 2.0 1 1 0 1 1 1 1 RmlD substrate binding domain PP-binding PF00550.25 ELR15810.1 - 0.0028 18.0 0.0 0.12 12.7 0.0 2.5 2 0 0 2 2 2 1 Phosphopantetheine attachment site PCM1_C PF15717.5 ELR15810.1 - 1.1 7.8 5.8 1.8 7.2 5.8 1.2 1 0 0 1 1 1 0 Pericentriolar material 1 C terminus AP3D1 PF06375.11 ELR15810.1 - 4.9 7.4 15.8 9.2 6.5 15.8 1.3 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 Clat_adaptor_s PF01217.20 ELR15811.1 - 8.9e-05 22.5 0.5 0.00011 22.1 0.5 1.1 1 0 0 1 1 1 1 Clathrin adaptor complex small chain Bac_globin PF01152.21 ELR15811.1 - 0.16 12.2 0.0 0.27 11.4 0.0 1.3 1 0 0 1 1 1 0 Bacterial-like globin Fringe PF02434.16 ELR15813.1 - 0.00026 20.5 0.1 0.00094 18.7 0.1 1.9 1 1 0 1 1 1 1 Fringe-like DDE_Tnp_1_7 PF13843.6 ELR15813.1 - 0.25 10.6 0.2 2.1 7.5 0.0 1.9 2 0 0 2 2 2 0 Transposase IS4 AMP-binding PF00501.28 ELR15814.1 - 1.2e-113 380.0 0.0 1.5e-113 379.6 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 ELR15814.1 - 1.3e-05 26.0 0.0 3.4e-05 24.7 0.0 1.7 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain GATA PF00320.27 ELR15815.1 - 8.5e-07 28.5 10.6 9.8e-05 21.9 2.4 2.5 2 0 0 2 2 2 2 GATA zinc finger DZR PF12773.7 ELR15815.1 - 0.98 9.5 3.8 22 5.2 3.8 2.4 1 1 0 1 1 1 0 Double zinc ribbon OrfB_Zn_ribbon PF07282.11 ELR15815.1 - 1.6 8.7 5.3 1.7 8.6 1.9 2.4 2 0 0 2 2 2 0 Putative transposase DNA-binding domain Steroid_dh PF02544.16 ELR15816.1 - 4.7e-38 130.5 2.2 4.7e-38 130.5 2.2 2.4 3 0 0 3 3 3 1 3-oxo-5-alpha-steroid 4-dehydrogenase ubiquitin PF00240.23 ELR15816.1 - 3.1e-06 26.9 0.0 5.3e-06 26.1 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin family DnaJ PF00226.31 ELR15816.1 - 0.0021 18.2 0.0 0.0036 17.4 0.0 1.4 1 0 0 1 1 1 1 DnaJ domain PEMT PF04191.13 ELR15816.1 - 0.0065 16.8 0.3 0.019 15.4 0.1 1.9 2 0 0 2 2 2 1 Phospholipid methyltransferase EFTUD2 PF16004.5 ELR15816.1 - 0.19 12.3 0.1 0.3 11.7 0.1 1.2 1 0 0 1 1 1 0 116 kDa U5 small nuclear ribonucleoprotein component N-terminus PigN PF04987.14 ELR15817.1 - 1.6e-122 409.7 44.1 2e-122 409.4 44.1 1.1 1 0 0 1 1 1 1 Phosphatidylinositolglycan class N (PIG-N) Phosphodiest PF01663.22 ELR15817.1 - 4.4e-09 36.4 1.8 2.3e-07 30.8 2.1 2.1 1 1 1 2 2 2 2 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.23 ELR15817.1 - 8.8e-09 35.2 0.3 1.5e-08 34.4 0.3 1.3 1 0 0 1 1 1 1 Sulfatase Acetyltransf_1 PF00583.25 ELR15818.1 - 9.1e-15 54.9 0.0 1.5e-14 54.2 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 ELR15818.1 - 2.5e-08 34.2 0.0 4.3e-08 33.5 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 ELR15818.1 - 2.3e-07 30.8 0.1 3.8e-07 30.1 0.1 1.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 ELR15818.1 - 5.7e-06 26.4 0.2 0.036 14.2 0.1 2.4 2 0 0 2 2 2 2 Acetyltransferase (GNAT) domain FR47 PF08445.10 ELR15818.1 - 1.4e-05 24.9 0.0 3e-05 23.9 0.0 1.5 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_8 PF13523.6 ELR15818.1 - 0.0031 17.2 0.0 0.0065 16.2 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 ELR15818.1 - 0.0043 17.2 0.0 0.0067 16.6 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.7 ELR15818.1 - 0.048 14.3 0.6 0.16 12.6 0.0 2.1 2 1 0 2 2 2 0 Acetyltransferase (GNAT) domain Acetyltransf_15 PF17013.5 ELR15818.1 - 0.051 13.0 0.1 0.079 12.4 0.1 1.2 1 0 0 1 1 1 0 Putative acetyl-transferase NMT PF01233.19 ELR15818.1 - 0.19 11.5 0.0 0.33 10.8 0.0 1.3 1 0 0 1 1 1 0 Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain Y_phosphatase3 PF13350.6 ELR15819.1 - 1e-13 51.8 0.0 1.8e-13 51.0 0.0 1.3 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase2 PF03162.13 ELR15819.1 - 7e-07 29.0 0.0 9.2e-07 28.6 0.0 1.2 1 0 0 1 1 1 1 Tyrosine phosphatase family DSPc PF00782.20 ELR15819.1 - 0.00028 20.7 0.0 0.00034 20.4 0.0 1.2 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 ELR15819.1 - 0.00029 20.5 0.0 0.00037 20.1 0.0 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Myotub-related PF06602.14 ELR15819.1 - 0.0021 17.1 0.0 0.0029 16.6 0.0 1.1 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain HMG_box PF00505.19 ELR15820.1 - 3.8e-32 110.5 9.9 3e-16 59.6 3.4 2.4 2 0 0 2 2 2 2 HMG (high mobility group) box HMG_box_2 PF09011.10 ELR15820.1 - 5.4e-21 75.0 6.9 1.6e-10 41.4 1.9 2.3 2 0 0 2 2 2 2 HMG-box domain F-box-like PF12937.7 ELR15820.1 - 7.1e-06 25.8 0.0 4e-05 23.4 0.0 2.2 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 ELR15820.1 - 1.1e-05 25.1 0.0 2.7e-05 23.9 0.0 1.6 1 0 0 1 1 1 1 F-box domain DUF3553 PF12073.8 ELR15820.1 - 0.039 13.7 0.4 0.079 12.7 0.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3553) Hint PF01079.20 ELR15821.1 - 2.1e-38 132.0 0.0 6.5e-38 130.4 0.0 1.7 1 1 0 1 1 1 1 Hint module Rho_N PF07498.12 ELR15822.1 - 2.5e-09 36.9 0.3 0.0025 17.7 0.1 2.4 2 0 0 2 2 2 2 Rho termination factor, N-terminal domain HeH PF12949.7 ELR15822.1 - 0.00073 19.2 0.7 0.0094 15.6 0.1 2.4 2 0 0 2 2 2 1 HeH/LEM domain FANC_SAP PF18081.1 ELR15822.1 - 0.87 9.8 8.3 6.7 7.0 1.3 2.5 1 1 1 2 2 2 0 Fanconi anemia-associated nuclease SAP domain Lyase_8 PF02278.18 ELR15825.1 - 1.1e-52 179.0 0.0 1.9e-52 178.3 0.0 1.4 1 0 0 1 1 1 1 Polysaccharide lyase family 8, super-sandwich domain Lyase_8_C PF02884.17 ELR15825.1 - 2.6e-12 47.0 0.0 5e-12 46.1 0.0 1.5 1 0 0 1 1 1 1 Polysaccharide lyase family 8, C-terminal beta-sandwich domain Lyase_8_N PF08124.11 ELR15825.1 - 0.24 10.3 0.1 0.36 9.7 0.1 1.2 1 0 0 1 1 1 0 Polysaccharide lyase family 8, N terminal alpha-helical domain BTB PF00651.31 ELR15826.1 - 0.023 14.9 0.0 0.039 14.2 0.0 1.3 1 0 0 1 1 1 0 BTB/POZ domain Linker_histone PF00538.19 ELR15828.1 - 1.3e-07 31.9 0.0 3e-07 30.7 0.1 1.5 2 0 0 2 2 2 1 linker histone H1 and H5 family DUF4423 PF14394.6 ELR15828.1 - 0.0012 18.6 0.0 0.0018 18.0 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4423) DUF505 PF04458.12 ELR15828.1 - 0.11 10.8 0.0 0.18 10.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF505) APH PF01636.23 ELR15829.1 - 1.1e-11 45.2 1.1 1.7e-07 31.4 0.8 2.0 1 1 1 2 2 2 2 Phosphotransferase enzyme family Pkinase PF00069.25 ELR15829.1 - 1.3e-06 28.0 0.0 1.5e-06 27.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain WaaY PF06176.11 ELR15829.1 - 0.0011 18.6 0.0 0.0013 18.4 0.0 1.1 1 0 0 1 1 1 1 Lipopolysaccharide core biosynthesis protein (WaaY) RIO1 PF01163.22 ELR15829.1 - 0.0019 17.8 0.0 0.0026 17.4 0.0 1.2 1 0 0 1 1 1 1 RIO1 family Haspin_kinase PF12330.8 ELR15829.1 - 0.0032 16.5 0.1 0.0046 16.0 0.1 1.2 1 0 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 ELR15829.1 - 0.0039 16.6 0.1 0.0053 16.1 0.1 1.1 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_Tyr PF07714.17 ELR15829.1 - 0.0051 16.1 0.0 0.0062 15.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Choline_kinase PF01633.20 ELR15829.1 - 0.079 12.5 0.1 0.1 12.2 0.1 1.1 1 0 0 1 1 1 0 Choline/ethanolamine kinase Pkinase_fungal PF17667.1 ELR15829.1 - 0.13 11.1 0.0 0.16 10.8 0.0 1.1 1 0 0 1 1 1 0 Fungal protein kinase F-box-like PF12937.7 ELR15830.1 - 0.0069 16.2 0.0 0.013 15.3 0.0 1.6 1 0 0 1 1 1 1 F-box-like ADH_N PF08240.12 ELR15832.1 - 1.5e-06 28.0 0.0 1.9e-06 27.7 0.0 1.1 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_N_2 PF16884.5 ELR15832.1 - 0.17 11.8 0.0 0.2 11.5 0.0 1.2 1 0 0 1 1 1 0 N-terminal domain of oxidoreductase Epimerase PF01370.21 ELR15833.1 - 0.0011 18.5 0.1 0.011 15.2 0.0 2.0 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family Capsid_NCLDV PF04451.12 ELR15834.1 - 4.4e-43 147.4 0.2 8.9e-43 146.4 0.1 1.5 2 0 0 2 2 2 1 Large eukaryotic DNA virus major capsid protein Capsid_N PF16903.5 ELR15834.1 - 2.1e-09 37.3 0.0 4.3e-09 36.3 0.0 1.5 2 0 0 2 2 2 1 Major capsid protein N-terminus Ank_4 PF13637.6 ELR15837.1 - 1.5e-11 44.5 6.9 0.09 13.4 0.1 6.7 3 2 4 7 7 7 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 ELR15837.1 - 2.2e-06 27.6 3.7 1.5 9.7 0.0 6.7 8 0 0 8 8 8 1 Ankyrin repeat Ank_5 PF13857.6 ELR15837.1 - 4.1e-06 27.0 5.2 4.7 7.6 0.0 5.8 4 2 2 6 6 6 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 ELR15837.1 - 4.5e-06 27.2 0.2 0.1 13.2 0.0 3.6 2 2 1 4 4 4 3 Ankyrin repeats (3 copies) DUF4551 PF15087.6 ELR15838.1 - 0.31 9.8 7.5 0.48 9.2 7.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) DUF3583 PF12126.8 ELR15839.1 - 0.22 10.9 8.6 0.28 10.6 8.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3583) Rib_recp_KP_reg PF05104.12 ELR15839.1 - 4.3 8.3 24.6 6.1 7.9 24.6 1.2 1 0 0 1 1 1 0 Ribosome receptor lysine/proline rich region SOG2 PF10428.9 ELR15839.1 - 7.5 5.6 15.8 8.9 5.4 15.8 1.0 1 0 0 1 1 1 0 RAM signalling pathway protein Trypan_PARP PF05887.11 ELR15841.1 - 0.087 12.8 0.2 0.087 12.8 0.2 5.2 2 1 2 4 4 4 0 Procyclic acidic repetitive protein (PARP) UDPGP PF01704.18 ELR15842.1 - 2e-180 599.8 0.0 2.4e-180 599.6 0.0 1.0 1 0 0 1 1 1 1 UTP--glucose-1-phosphate uridylyltransferase HNOB PF07700.15 ELR15844.1 - 4.5e-31 108.0 0.0 1.1e-30 106.7 0.0 1.7 2 0 0 2 2 2 1 Haem-NO-binding HNOBA PF07701.14 ELR15844.1 - 2.4e-21 76.2 0.3 1.9e-09 37.3 0.1 2.4 1 1 1 2 2 2 2 Heme NO binding associated RasGAP PF00616.19 ELR15844.1 - 1.3e-08 34.8 0.0 1.9e-06 27.7 0.0 2.6 1 1 1 2 2 2 2 GTPase-activator protein for Ras-like GTPase Amidohydro_2 PF04909.14 ELR15844.1 - 0.011 15.5 0.0 0.021 14.6 0.0 1.4 1 0 0 1 1 1 0 Amidohydrolase HNOB PF07700.15 ELR15845.1 - 4.1e-31 108.1 0.0 1e-30 106.9 0.0 1.7 1 0 0 1 1 1 1 Haem-NO-binding HNOBA PF07701.14 ELR15845.1 - 2.1e-21 76.4 0.1 1.7e-09 37.5 0.0 2.4 1 1 1 2 2 2 2 Heme NO binding associated RasGAP PF00616.19 ELR15845.1 - 1e-15 58.1 0.1 5.5e-13 49.1 0.1 2.4 1 1 1 2 2 2 2 GTPase-activator protein for Ras-like GTPase ORC4_C PF14629.6 ELR15846.1 - 3.9e-26 91.8 0.1 7e-26 90.9 0.1 1.4 1 0 0 1 1 1 1 Origin recognition complex (ORC) subunit 4 C-terminus AAA_16 PF13191.6 ELR15846.1 - 1.2e-11 45.4 1.0 1.2e-11 45.4 1.0 2.4 3 0 0 3 3 3 1 AAA ATPase domain AAA_22 PF13401.6 ELR15846.1 - 0.00015 22.0 1.2 0.0017 18.6 0.4 2.8 2 1 0 2 2 2 1 AAA domain AAA PF00004.29 ELR15846.1 - 0.0016 18.8 0.2 3.5 8.1 0.0 2.8 2 1 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) MMR_HSR1 PF01926.23 ELR15846.1 - 0.0062 16.6 0.0 0.028 14.5 0.0 2.2 1 1 1 2 2 2 1 50S ribosome-binding GTPase TERB2 PF15101.6 ELR15846.1 - 0.019 15.0 3.9 0.036 14.1 3.9 1.4 1 0 0 1 1 1 0 Telomere-associated protein TERB2 DDHD PF02862.17 ELR15846.1 - 0.02 15.1 0.1 0.025 14.7 0.1 1.2 1 0 0 1 1 1 0 DDHD domain Velvet PF11754.8 ELR15846.1 - 0.027 14.4 0.1 0.048 13.6 0.1 1.4 1 0 0 1 1 1 0 Velvet factor DUF4834 PF16118.5 ELR15846.1 - 0.031 15.2 1.2 0.062 14.3 1.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) AAA_7 PF12775.7 ELR15846.1 - 0.038 13.5 0.0 0.15 11.5 0.0 1.9 2 0 0 2 2 2 0 P-loop containing dynein motor region Spt20 PF12090.8 ELR15846.1 - 0.081 12.5 10.5 0.16 11.6 10.5 1.4 1 0 0 1 1 1 0 Spt20 family DUF4407 PF14362.6 ELR15846.1 - 0.091 12.1 5.0 0.075 12.4 3.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) CPSF100_C PF13299.6 ELR15846.1 - 0.096 12.9 2.4 0.17 12.0 2.4 1.4 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal ALMT PF11744.8 ELR15846.1 - 0.098 11.5 0.9 0.14 10.9 0.9 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter DUF572 PF04502.13 ELR15846.1 - 0.12 12.0 4.9 0.22 11.1 4.9 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF572) Presenilin PF01080.17 ELR15846.1 - 0.15 10.8 2.1 0.21 10.3 2.1 1.2 1 0 0 1 1 1 0 Presenilin Hid1 PF12722.7 ELR15846.1 - 0.15 10.2 4.4 0.2 9.7 4.4 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein tRNA-synt_2c PF01411.19 ELR15846.1 - 0.3 9.6 3.9 0.53 8.7 3.9 1.3 1 0 0 1 1 1 0 tRNA synthetases class II (A) Atrophin-1 PF03154.15 ELR15846.1 - 1.1 7.4 5.6 1.6 6.9 5.6 1.1 1 0 0 1 1 1 0 Atrophin-1 family FAM176 PF14851.6 ELR15846.1 - 1.6 8.4 7.8 0.085 12.5 2.4 1.6 2 0 0 2 2 1 0 FAM176 family Androgen_recep PF02166.16 ELR15846.1 - 9.5 4.9 10.0 13 4.5 10.0 1.1 1 0 0 1 1 1 0 Androgen receptor Methyltransf_16 PF10294.9 ELR15847.1 - 4.6e-14 52.5 0.0 7.4e-14 51.9 0.0 1.3 1 0 0 1 1 1 1 Lysine methyltransferase Cons_hypoth95 PF03602.15 ELR15847.1 - 4.8e-05 23.1 0.0 7.8e-05 22.4 0.0 1.3 1 0 0 1 1 1 1 Conserved hypothetical protein 95 MTS PF05175.14 ELR15847.1 - 0.059 12.9 0.1 0.1 12.2 0.1 1.4 1 0 0 1 1 1 0 Methyltransferase small domain PCMT PF01135.19 ELR15847.1 - 0.06 13.1 0.0 0.096 12.4 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) PrmA PF06325.13 ELR15847.1 - 0.12 11.8 0.0 0.16 11.3 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Nodulin-like PF06813.13 ELR15848.1 - 2.8e-26 92.5 6.8 2.8e-26 92.5 6.8 1.8 2 0 0 2 2 2 1 Nodulin-like MFS_1 PF07690.16 ELR15848.1 - 1.5e-21 76.8 40.0 4.1e-13 49.0 16.3 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Phage_holin_3_6 PF07332.11 ELR15848.1 - 0.03 14.4 0.1 0.03 14.4 0.1 5.1 4 2 0 4 4 4 0 Putative Actinobacterial Holin-X, holin superfamily III Ank_4 PF13637.6 ELR15849.1 - 3.2e-12 46.7 2.4 0.017 15.7 0.0 6.5 2 2 4 6 6 6 4 Ankyrin repeats (many copies) Ank_5 PF13857.6 ELR15849.1 - 3.9e-10 39.8 1.9 0.16 12.3 0.0 6.9 5 2 2 7 7 7 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 ELR15849.1 - 2.1e-07 31.4 0.1 0.0046 17.5 0.0 3.7 1 1 3 4 4 4 3 Ankyrin repeats (3 copies) Ank_3 PF13606.6 ELR15849.1 - 0.00027 21.1 0.1 4.6 8.1 0.0 5.6 6 1 0 6 6 6 1 Ankyrin repeat F-box PF00646.33 ELR15849.1 - 0.0042 16.9 0.0 0.0081 16.0 0.0 1.4 1 0 0 1 1 1 1 F-box domain DUF2795 PF11387.8 ELR15849.1 - 0.0071 16.5 0.1 66 3.8 0.0 4.6 5 0 0 5 5 5 0 Protein of unknown function (DUF2795) CTP_transf_like PF01467.26 ELR15849.1 - 0.22 11.7 0.4 48 4.1 0.0 3.8 4 0 0 4 4 4 0 Cytidylyltransferase-like Cys_Met_Meta_PP PF01053.20 ELR15850.1 - 1.1e-81 274.4 0.0 1.4e-81 274.0 0.0 1.1 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme GDC-P PF02347.16 ELR15850.1 - 3.8e-05 22.7 0.0 5.7e-05 22.1 0.0 1.1 1 0 0 1 1 1 1 Glycine cleavage system P-protein Aminotran_1_2 PF00155.21 ELR15850.1 - 0.00042 19.6 0.0 0.00062 19.0 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II Met_gamma_lyase PF06838.11 ELR15850.1 - 0.012 14.2 0.0 0.025 13.1 0.0 1.5 1 1 0 1 1 1 0 Methionine gamma-lyase RNA_lig_T4_1 PF09511.10 ELR15851.1 - 3.4e-30 105.6 0.0 5.4e-30 104.9 0.0 1.3 1 0 0 1 1 1 1 RNA ligase RNA_ligase PF09414.10 ELR15851.1 - 0.0097 16.2 0.0 0.043 14.1 0.0 2.0 1 1 0 1 1 1 1 RNA ligase EspA PF03433.13 ELR15851.1 - 0.065 13.1 0.0 0.14 12.0 0.0 1.5 1 0 0 1 1 1 0 EspA-like secreted protein zf-RING_11 PF17123.5 ELR15852.1 - 5.3e-11 42.1 3.3 9e-11 41.3 3.3 1.4 1 0 0 1 1 1 1 RING-like zinc finger zf-RING_2 PF13639.6 ELR15852.1 - 1.2e-07 31.9 4.0 2.2e-07 31.1 4.0 1.4 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 ELR15852.1 - 0.00054 19.8 3.8 0.00098 18.9 3.8 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 ELR15852.1 - 0.0006 19.6 3.5 0.0011 18.7 3.5 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ELR15852.1 - 0.00098 19.0 3.1 0.0018 18.2 3.1 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 ELR15852.1 - 0.0018 18.2 2.7 0.0035 17.3 2.7 1.4 1 0 0 1 1 1 1 RING-type zinc-finger UPF0014 PF03649.13 ELR15852.1 - 0.12 11.8 3.0 0.16 11.3 3.0 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0014) D123 PF07065.14 ELR15853.1 - 1.2e-17 64.0 7.1 4.4e-14 52.4 0.0 3.1 2 1 0 3 3 3 2 D123 R2K_2 PF18299.1 ELR15853.1 - 0.00011 22.1 0.2 0.00026 20.9 0.2 1.6 1 0 0 1 1 1 1 ATP-grasp domain, R2K clade family 2 R2K_3 PF14243.6 ELR15853.1 - 0.00056 20.0 0.2 0.0016 18.5 0.2 1.9 1 0 0 1 1 1 1 ATP-grasp domain, R2K clade family 3 Cwf_Cwc_15 PF04889.12 ELR15853.1 - 0.61 9.8 8.0 1 9.0 8.0 1.3 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein RXT2_N PF08595.11 ELR15853.1 - 0.68 10.0 3.0 1.2 9.2 3.0 1.3 1 0 0 1 1 1 0 RXT2-like, N-terminal NOA36 PF06524.12 ELR15853.1 - 1.3 8.2 12.7 2.1 7.6 12.7 1.2 1 0 0 1 1 1 0 NOA36 protein FAM176 PF14851.6 ELR15853.1 - 1.8 8.2 4.8 3.7 7.2 4.8 1.4 1 0 0 1 1 1 0 FAM176 family Nop14 PF04147.12 ELR15853.1 - 3.7 5.6 7.9 5.9 5.0 7.9 1.2 1 0 0 1 1 1 0 Nop14-like family CENP-B_dimeris PF09026.10 ELR15853.1 - 3.9 7.9 16.7 12 6.4 16.7 1.8 1 0 0 1 1 1 0 Centromere protein B dimerisation domain DNA_pol_phi PF04931.13 ELR15853.1 - 7.9 4.4 16.1 12 3.9 16.1 1.2 1 0 0 1 1 1 0 DNA polymerase phi RSN1_TM PF13967.6 ELR15854.1 - 0.042 13.6 0.1 0.082 12.7 0.1 1.4 1 0 0 1 1 1 0 Late exocytosis, associated with Golgi transport Stevor PF17410.2 ELR15854.1 - 0.063 12.8 1.5 0.5 9.9 0.5 2.2 2 0 0 2 2 2 0 Subtelomeric Variable Open Reading frame Orf78 PF06024.12 ELR15854.1 - 0.12 12.7 3.7 0.38 11.1 0.0 2.8 3 0 0 3 3 3 0 Orf78 (ac78) Prothymosin PF03247.14 ELR15854.1 - 0.24 11.9 33.9 0.5 10.8 20.5 2.8 2 0 0 2 2 2 0 Prothymosin/parathymosin family FAM176 PF14851.6 ELR15854.1 - 0.34 10.6 14.5 6.7 6.4 10.3 3.2 3 0 0 3 3 3 0 FAM176 family Usp PF00582.26 ELR15854.1 - 0.38 11.3 10.8 5.9 7.4 0.2 2.7 2 0 0 2 2 2 0 Universal stress protein family Tmemb_9 PF05434.11 ELR15854.1 - 0.67 9.8 0.0 0.67 9.8 0.0 2.7 3 0 0 3 3 3 0 TMEM9 RXT2_N PF08595.11 ELR15854.1 - 0.95 9.5 11.1 0.96 9.5 4.5 2.3 2 0 0 2 2 2 0 RXT2-like, N-terminal DUF4834 PF16118.5 ELR15854.1 - 1 10.4 0.0 1 10.4 0.0 3.5 3 1 0 3 3 2 0 Domain of unknown function (DUF4834) CPSF100_C PF13299.6 ELR15854.1 - 1.6 8.9 12.4 11 6.2 9.2 2.3 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal DUF2052 PF09747.9 ELR15854.1 - 1.7 8.7 31.5 77 3.3 0.0 3.2 2 1 0 3 3 3 0 Coiled-coil domain containing protein (DUF2052) Sigma70_ner PF04546.13 ELR15854.1 - 1.8 8.4 15.9 4.1 7.2 9.8 2.2 2 0 0 2 2 2 0 Sigma-70, non-essential region GAGA_bind PF06217.12 ELR15854.1 - 1.8 8.8 9.1 3 8.1 9.1 1.3 1 0 0 1 1 1 0 GAGA binding protein-like family Cwf_Cwc_15 PF04889.12 ELR15854.1 - 2.2 7.9 19.1 2.2 8.0 12.7 2.3 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein DNA_pol_phi PF04931.13 ELR15854.1 - 2.3 6.2 19.9 1.5 6.9 12.4 2.1 2 0 0 2 2 2 0 DNA polymerase phi Shisa PF13908.6 ELR15854.1 - 4.8 7.4 5.7 0.38 11.0 0.2 2.0 2 0 0 2 2 1 0 Wnt and FGF inhibitory regulator DUF4366 PF14283.6 ELR15854.1 - 4.9 7.2 6.7 2.5e+02 1.7 6.8 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4366) Nop53 PF07767.11 ELR15854.1 - 6.1 6.1 26.6 0.47 9.8 19.7 2.0 2 0 0 2 2 2 0 Nop53 (60S ribosomal biogenesis) Radial_spoke PF04712.12 ELR15854.1 - 6.7 5.5 20.6 1.3 7.8 13.7 2.3 2 0 0 2 2 2 0 Radial spokehead-like protein HAUS4 PF14735.6 ELR15855.1 - 2.8e-45 154.8 8.0 4e-45 154.4 8.0 1.2 1 0 0 1 1 1 1 HAUS augmin-like complex subunit 4 Seryl_tRNA_N PF02403.22 ELR15855.1 - 0.1 12.9 0.3 0.1 12.9 0.3 3.5 3 1 0 3 3 3 0 Seryl-tRNA synthetase N-terminal domain DUF3135 PF11333.8 ELR15855.1 - 0.2 11.9 0.3 0.2 11.9 0.3 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF3135) Cep57_MT_bd PF06657.13 ELR15855.1 - 1.2 9.6 8.4 0.13 12.8 1.3 2.9 3 0 0 3 3 3 0 Centrosome microtubule-binding domain of Cep57 TMF_TATA_bd PF12325.8 ELR15855.1 - 2.3 8.5 11.8 2.2 8.5 1.2 3.1 3 1 0 3 3 3 0 TATA element modulatory factor 1 TATA binding Pkinase_Tyr PF07714.17 ELR15856.1 - 2.7e-48 164.5 0.0 5.7e-48 163.5 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ELR15856.1 - 2.1e-45 155.1 0.0 3.6e-45 154.4 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain SH2 PF00017.24 ELR15856.1 - 2.6e-13 49.8 0.0 7.9e-13 48.3 0.0 1.8 1 0 0 1 1 1 1 SH2 domain SH2_2 PF14633.6 ELR15856.1 - 0.00019 20.9 0.0 0.0039 16.6 0.0 2.5 2 0 0 2 2 2 1 SH2 domain Cbl_N2 PF02761.14 ELR15856.1 - 0.0046 17.6 1.7 0.022 15.5 1.7 2.2 1 1 0 1 1 1 1 CBL proto-oncogene N-terminus, EF hand-like domain HCV_NS5a_C PF12941.7 ELR15856.1 - 0.05 13.4 0.0 0.084 12.7 0.0 1.3 1 0 0 1 1 1 0 HCV NS5a protein C-terminal region IBP39 PF11422.8 ELR15856.1 - 0.099 12.4 0.7 0.2 11.4 0.7 1.5 1 0 0 1 1 1 0 Initiator binding protein 39 kDa PRRSV_Env PF02340.15 ELR15856.1 - 0.13 11.6 0.0 0.24 10.7 0.0 1.3 1 0 0 1 1 1 0 PRRSV putative envelope protein DUF5060 PF16586.5 ELR15856.1 - 0.16 12.3 0.1 0.38 11.2 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF5060) Spore_III_AB PF09548.10 ELR15856.1 - 0.99 9.5 6.1 2.6 8.2 6.1 1.7 1 0 0 1 1 1 0 Stage III sporulation protein AB (spore_III_AB) ADH_zinc_N PF00107.26 ELR15857.1 - 1e-16 61.1 0.0 1.9e-16 60.2 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 ELR15857.1 - 3.8e-08 33.2 0.3 1.8e-07 31.0 0.3 1.9 1 1 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.6 ELR15857.1 - 7e-07 30.4 0.0 3.1e-06 28.3 0.0 2.0 1 1 0 1 1 1 1 Zinc-binding dehydrogenase Ank_2 PF12796.7 ELR15858.1 - 6.1e-22 78.0 0.0 2.8e-09 37.4 0.0 3.7 1 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank PF00023.30 ELR15858.1 - 4.6e-18 64.8 1.1 4.4e-05 23.7 0.0 7.1 7 1 1 8 8 8 4 Ankyrin repeat Ank_4 PF13637.6 ELR15858.1 - 3.7e-15 56.1 1.5 2.3e-05 24.9 0.0 6.5 3 2 4 7 7 7 5 Ankyrin repeats (many copies) Ank_5 PF13857.6 ELR15858.1 - 3.7e-14 52.6 4.1 2.1e-08 34.3 0.1 5.3 3 2 3 6 6 6 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 ELR15858.1 - 8e-13 47.3 0.3 0.004 17.5 0.0 6.8 7 0 0 7 7 7 3 Ankyrin repeat SK_channel PF03530.14 ELR15858.1 - 0.2 11.6 0.0 0.35 10.9 0.0 1.3 1 0 0 1 1 1 0 Calcium-activated SK potassium channel F-box-like PF12937.7 ELR15858.1 - 0.77 9.7 2.9 2.3 8.2 2.9 1.8 1 0 0 1 1 1 0 F-box-like Lys PF00062.20 ELR15861.1 - 2.7e-05 24.4 5.0 5.5e-05 23.4 5.0 1.6 1 1 0 1 1 1 1 C-type lysozyme/alpha-lactalbumin family SLT PF01464.20 ELR15861.1 - 5.8e-05 22.7 0.0 6.8e-05 22.5 0.0 1.1 1 0 0 1 1 1 1 Transglycosylase SLT domain THF_DHG_CYH_C PF02882.19 ELR15862.1 - 1.3e-46 157.8 0.2 1.5e-46 157.7 0.2 1.0 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain OCD_Mu_crystall PF02423.15 ELR15862.1 - 0.012 14.6 0.1 0.013 14.5 0.1 1.1 1 0 0 1 1 1 0 Ornithine cyclodeaminase/mu-crystallin family IFRD PF05004.13 ELR15864.1 - 1.4e-06 27.7 0.0 1.4e-06 27.7 0.0 2.1 2 0 0 2 2 1 1 Interferon-related developmental regulator (IFRD) NOA36 PF06524.12 ELR15864.1 - 0.034 13.5 16.0 0.081 12.2 16.0 1.6 1 0 0 1 1 1 0 NOA36 protein DUF4913 PF16259.5 ELR15864.1 - 0.092 12.8 0.2 0.22 11.6 0.2 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4913) DUF2722 PF10846.8 ELR15864.1 - 0.67 8.8 3.0 1 8.2 3.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) AATF-Che1 PF13339.6 ELR15864.1 - 0.91 10.2 5.6 0.69 10.6 1.4 2.2 2 0 0 2 2 2 0 Apoptosis antagonizing transcription factor PPP4R2 PF09184.11 ELR15864.1 - 0.94 9.0 12.3 1.6 8.2 12.3 1.3 1 0 0 1 1 1 0 PPP4R2 DOG1 PF14144.6 ELR15864.1 - 1.2 9.4 5.0 11 6.3 0.5 2.8 2 0 0 2 2 2 0 Seed dormancy control Sporozoite_P67 PF05642.11 ELR15864.1 - 2.3 6.2 6.0 3.3 5.7 6.0 1.2 1 0 0 1 1 1 0 Sporozoite P67 surface antigen RRN3 PF05327.11 ELR15864.1 - 3 6.3 10.2 5.8 5.3 10.2 1.5 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 TRAP_alpha PF03896.16 ELR15864.1 - 4.6 6.4 5.0 8 5.6 5.0 1.3 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit BUD22 PF09073.10 ELR15864.1 - 4.6 6.5 14.4 1.3 8.3 9.0 2.1 2 0 0 2 2 2 0 BUD22 Dicty_REP PF05086.12 ELR15864.1 - 6.8 4.5 7.9 9.3 4.1 7.9 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Myc_N PF01056.18 ELR15864.1 - 9.1 6.1 7.9 1.6 8.5 3.9 1.7 2 0 0 2 2 2 0 Myc amino-terminal region THF_DHG_CYH_C PF02882.19 ELR15865.1 - 3.7e-69 231.1 0.5 6.6e-69 230.3 0.5 1.4 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain THF_DHG_CYH PF00763.23 ELR15865.1 - 6.3e-40 136.1 0.2 1e-39 135.4 0.2 1.3 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain OCD_Mu_crystall PF02423.15 ELR15865.1 - 0.039 12.9 0.1 0.062 12.2 0.1 1.3 1 0 0 1 1 1 0 Ornithine cyclodeaminase/mu-crystallin family IFRD PF05004.13 ELR15866.1 - 2.9e-06 26.6 0.0 2.9e-06 26.6 0.0 2.1 2 0 0 2 2 1 1 Interferon-related developmental regulator (IFRD) FAM176 PF14851.6 ELR15866.1 - 0.026 14.2 2.6 0.099 12.3 2.6 2.0 1 0 0 1 1 1 0 FAM176 family RP-C_C PF11800.8 ELR15866.1 - 0.028 14.5 0.5 0.028 14.5 0.5 1.7 2 0 0 2 2 2 0 Replication protein C C-terminal region NOA36 PF06524.12 ELR15866.1 - 0.044 13.1 16.0 0.12 11.7 16.0 1.7 1 0 0 1 1 1 0 NOA36 protein DUF2722 PF10846.8 ELR15866.1 - 0.19 10.6 3.0 0.29 10.0 3.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Sporozoite_P67 PF05642.11 ELR15866.1 - 0.45 8.5 3.8 0.68 8.0 3.8 1.2 1 0 0 1 1 1 0 Sporozoite P67 surface antigen TFB6 PF17110.5 ELR15866.1 - 0.51 10.1 7.7 1.3 8.7 7.7 1.6 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH PPP4R2 PF09184.11 ELR15866.1 - 0.6 9.7 11.8 1.1 8.8 11.8 1.4 1 0 0 1 1 1 0 PPP4R2 Myc_N PF01056.18 ELR15866.1 - 0.66 9.8 4.5 1.5 8.7 4.5 1.5 1 0 0 1 1 1 0 Myc amino-terminal region RXT2_N PF08595.11 ELR15866.1 - 0.68 9.9 8.2 1.7 8.7 8.2 1.7 1 0 0 1 1 1 0 RXT2-like, N-terminal Rhabdo_ncap PF00945.18 ELR15866.1 - 0.77 8.6 2.1 1.2 7.9 2.1 1.3 1 0 0 1 1 1 0 Rhabdovirus nucleocapsid protein DOG1 PF14144.6 ELR15866.1 - 1.5 9.1 4.7 17 5.7 0.4 2.9 2 0 0 2 2 2 0 Seed dormancy control Nop14 PF04147.12 ELR15866.1 - 3.1 5.9 14.2 5.4 5.1 14.2 1.3 1 0 0 1 1 1 0 Nop14-like family DUF4611 PF15387.6 ELR15866.1 - 3.1 8.1 21.2 0.026 14.8 10.7 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4611) TRAP_alpha PF03896.16 ELR15866.1 - 3.6 6.7 5.4 6.7 5.8 5.4 1.4 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit RRN3 PF05327.11 ELR15866.1 - 4 5.9 11.0 6.5 5.2 11.0 1.3 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 RNA_pol_3_Rpc31 PF11705.8 ELR15866.1 - 7.5 6.7 21.0 1.4 9.1 17.0 1.9 2 0 0 2 2 2 0 DNA-directed RNA polymerase III subunit Rpc31 BUD22 PF09073.10 ELR15866.1 - 8.4 5.6 15.2 2.1 7.6 10.1 2.3 2 0 0 2 2 2 0 BUD22 Glyco_hydro_76 PF03663.14 ELR15867.1 - 8.5e-16 58.4 9.8 4.5e-15 56.0 8.2 2.1 1 1 1 2 2 2 2 Glycosyl hydrolase family 76 C5-epim_C PF06662.13 ELR15867.1 - 0.022 14.3 1.2 0.18 11.3 0.1 2.3 1 1 0 2 2 2 0 D-glucuronyl C5-epimerase C-terminus Glyco_hydro_47 PF01532.20 ELR15867.1 - 0.037 12.9 0.0 0.054 12.4 0.0 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase family 47 CM_2 PF01817.21 ELR15868.1 - 1.8e-08 34.6 0.0 5e-08 33.2 0.0 1.7 2 0 0 2 2 2 1 Chorismate mutase type II Baculo_PEP_C PF04513.12 ELR15868.1 - 0.024 14.7 2.1 0.054 13.5 2.1 1.5 1 1 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus Fzo_mitofusin PF04799.13 ELR15868.1 - 0.091 12.3 0.3 0.17 11.5 0.0 1.6 2 0 0 2 2 2 0 fzo-like conserved region DUF2205 PF10224.9 ELR15868.1 - 0.12 12.3 0.2 0.26 11.3 0.2 1.5 1 0 0 1 1 1 0 Short coiled-coil protein DUF3138 PF11336.8 ELR15868.1 - 1.3 7.6 7.7 0.79 8.3 6.5 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF3138) CBM49 PF09478.10 ELR15869.1 - 7.2e-30 103.1 1.6 1.7e-13 50.7 0.1 3.2 3 0 0 3 3 3 3 Carbohydrate binding domain CBM49 CBM_2 PF00553.19 ELR15869.1 - 1.1e-08 35.3 15.1 0.00037 20.7 0.2 4.1 3 2 1 4 4 4 2 Cellulose binding domain DUF4354 PF14263.6 ELR15869.1 - 0.023 14.5 0.0 1.8 8.4 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4354) DUF4352 PF11611.8 ELR15869.1 - 0.14 12.4 0.0 18 5.7 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4352) NAD_binding_1 PF00175.21 ELR15870.1 - 9e-32 110.0 0.0 1.9e-31 108.9 0.0 1.6 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.24 ELR15870.1 - 1.7e-24 86.0 0.0 3e-24 85.2 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_6 PF08030.12 ELR15870.1 - 1.8e-06 28.2 0.0 0.00024 21.2 0.0 2.5 1 1 1 2 2 2 2 Ferric reductase NAD binding domain AIF-MLS PF14962.6 ELR15870.1 - 0.0014 18.6 0.0 0.0023 17.9 0.0 1.4 1 0 0 1 1 1 1 Mitochondria Localisation Sequence FAD_binding_9 PF08021.11 ELR15870.1 - 0.044 14.0 0.0 0.54 10.5 0.0 2.4 2 1 1 3 3 3 0 Siderophore-interacting FAD-binding domain Cob_adeno_trans PF01923.18 ELR15871.1 - 2.5e-46 157.8 0.0 3.9e-46 157.2 0.0 1.3 1 0 0 1 1 1 1 Cobalamin adenosyltransferase LRR_4 PF12799.7 ELR15871.1 - 3.6e-06 27.2 0.0 0.81 10.2 0.0 4.3 4 1 1 5 5 5 3 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 ELR15871.1 - 0.0014 18.9 1.1 6.7 7.7 0.0 4.3 4 0 0 4 4 4 1 Leucine Rich Repeat LRR_6 PF13516.6 ELR15871.1 - 0.02 14.9 7.6 10 6.4 0.0 4.8 5 0 0 5 5 5 0 Leucine Rich repeat UQ_con PF00179.26 ELR15872.1 - 9.8e-55 184.0 0.0 1.1e-54 183.9 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 ELR15872.1 - 0.0025 17.5 0.0 0.003 17.2 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.22 ELR15872.1 - 0.0045 17.3 0.0 0.0066 16.7 0.0 1.5 1 0 0 1 1 1 1 RWD domain UEV PF05743.13 ELR15872.1 - 0.047 13.5 0.0 0.072 13.0 0.0 1.3 1 0 0 1 1 1 0 UEV domain F-box-like PF12937.7 ELR15873.1 - 4.4e-07 29.7 0.0 1.1e-06 28.4 0.0 1.7 1 0 0 1 1 1 1 F-box-like DUF2069 PF09842.9 ELR15874.1 - 0.0036 17.5 0.4 0.0097 16.1 0.4 1.7 1 0 0 1 1 1 1 Predicted membrane protein (DUF2069) Importin_rep_3 PF18806.1 ELR15874.1 - 0.027 14.5 0.0 0.11 12.5 0.0 2.1 1 0 0 1 1 1 0 Importin 13 repeat HEAT_EZ PF13513.6 ELR15874.1 - 0.042 14.4 0.0 5.3 7.6 0.0 3.6 2 0 0 2 2 2 0 HEAT-like repeat MMS19_C PF12460.8 ELR15874.1 - 0.044 12.9 1.8 1.2 8.2 0.4 2.7 2 0 0 2 2 2 0 RNAPII transcription regulator C-terminal DUF3385 PF11865.8 ELR15874.1 - 0.13 12.1 0.1 12 5.8 0.1 3.4 2 1 1 3 3 3 0 Domain of unknown function (DUF3385) RsbRD_N PF14361.6 ELR15874.1 - 0.22 12.2 1.7 28 5.5 0.1 3.3 3 0 0 3 3 3 0 RsbT co-antagonist protein rsbRD N-terminal domain TetR_C_15 PF17918.1 ELR15874.1 - 7.7 7.3 7.1 17 6.2 0.1 3.7 5 0 0 5 5 5 0 Tetracyclin repressor-like, C-terminal domain Methyltransf_2 PF00891.18 ELR15875.1 - 7.2e-38 130.0 0.2 2e-36 125.3 0.2 2.5 2 1 0 2 2 2 1 O-methyltransferase domain Dimerisation2 PF16864.5 ELR15875.1 - 8.2e-10 38.5 0.0 1.8e-09 37.4 0.0 1.6 1 0 0 1 1 1 1 Dimerisation domain Dimerisation PF08100.11 ELR15875.1 - 7.2e-07 29.1 0.0 1.7e-06 28.0 0.0 1.6 1 0 0 1 1 1 1 Dimerisation domain GRDP-like PF07173.12 ELR15876.1 - 5.2e-13 49.8 1.6 5.3e-06 27.2 0.3 2.9 2 1 1 3 3 3 2 Glycine-rich domain-containing protein-like Iso_dh PF00180.20 ELR15878.1 - 7.9e-64 216.0 0.0 4.9e-57 193.6 0.0 2.7 1 1 2 3 3 3 2 Isocitrate/isopropylmalate dehydrogenase Phe_ZIP PF08916.11 ELR15878.1 - 0.027 15.2 0.1 0.069 13.9 0.1 1.7 1 0 0 1 1 1 0 Phenylalanine zipper IBR PF01485.21 ELR15879.1 - 1.8e-26 92.1 47.5 2.9e-16 59.4 6.3 4.7 3 1 1 4 4 4 3 IBR domain, a half RING-finger domain zf-C3HC4 PF00097.25 ELR15879.1 - 5.5e-05 23.0 6.5 5.5e-05 23.0 6.5 4.6 3 1 1 4 4 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 ELR15879.1 - 0.00061 19.8 7.8 0.00061 19.8 7.8 3.6 3 0 0 3 3 3 1 RING-type zinc-finger zf-RING_2 PF13639.6 ELR15879.1 - 0.0011 19.3 8.5 0.0011 19.3 8.5 4.1 3 1 1 4 4 4 1 Ring finger domain zf-RING_5 PF14634.6 ELR15879.1 - 0.0051 16.8 9.2 0.0051 16.8 9.2 4.1 2 1 1 3 3 1 1 zinc-RING finger domain RRM_1 PF00076.22 ELR15879.1 - 0.02 14.7 0.0 0.054 13.3 0.0 1.8 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SR-25 PF10500.9 ELR15879.1 - 0.16 11.6 13.8 0.36 10.4 13.8 1.7 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein PAP1 PF08601.10 ELR15879.1 - 0.22 11.2 7.0 0.36 10.5 7.0 1.3 1 0 0 1 1 1 0 Transcription factor PAP1 IMUP PF15761.5 ELR15879.1 - 0.36 11.5 6.1 0.93 10.2 6.1 1.7 1 0 0 1 1 1 0 Immortalisation up-regulated protein DUF755 PF05501.11 ELR15879.1 - 3.9 7.8 16.2 11 6.3 16.2 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF755) zf-C3HC4_2 PF13923.6 ELR15879.1 - 7 6.6 38.5 0.17 11.7 9.0 4.5 3 2 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) tRNA-synt_1 PF00133.22 ELR15880.1 - 8.7e-65 219.1 1.2 4.5e-24 84.7 0.8 6.1 2 1 3 5 5 5 5 tRNA synthetases class I (I, L, M and V) tRNA-synt_1_2 PF13603.6 ELR15880.1 - 9.9e-58 194.7 0.0 1.7e-57 193.9 0.0 1.4 1 0 0 1 1 1 1 Leucyl-tRNA synthetase, Domain 2 tRNA-synt_1g PF09334.11 ELR15880.1 - 2.1e-29 102.5 0.0 2.1e-21 76.2 0.0 4.3 3 1 1 4 4 4 3 tRNA synthetases class I (M) Anticodon_1 PF08264.13 ELR15880.1 - 7.6e-12 45.4 0.1 2.2e-11 44.0 0.1 1.7 1 1 0 1 1 1 1 Anticodon-binding domain of tRNA Lar_restr_allev PF14354.6 ELR15880.1 - 0.0037 17.6 0.2 5.5 7.4 0.0 2.8 2 0 0 2 2 2 2 Restriction alleviation protein Lar tRNA-synt_1e PF01406.19 ELR15880.1 - 0.012 15.0 0.0 0.98 8.7 0.0 2.4 2 0 0 2 2 2 0 tRNA synthetases class I (C) catalytic domain IU_nuc_hydro PF01156.19 ELR15881.1 - 1.5e-20 74.0 0.0 1.9e-20 73.6 0.0 1.1 1 0 0 1 1 1 1 Inosine-uridine preferring nucleoside hydrolase CH PF00307.31 ELR15882.1 - 6.3e-18 64.9 0.0 7.4e-18 64.7 0.0 1.1 1 0 0 1 1 1 1 Calponin homology (CH) domain CDC24 PF06395.11 ELR15882.1 - 0.0081 16.4 0.0 0.012 15.9 0.0 1.2 1 0 0 1 1 1 1 CDC24 Calponin CAP PF00188.26 ELR15883.1 - 3.4e-19 69.9 3.4 6e-19 69.1 3.4 1.4 1 0 0 1 1 1 1 Cysteine-rich secretory protein family SKG6 PF08693.10 ELR15883.1 - 0.24 10.9 17.0 0.072 12.5 8.6 2.8 2 0 0 2 2 2 0 Transmembrane alpha-helix domain Insulin_TMD PF17870.1 ELR15883.1 - 1.7 8.8 6.3 0.58 10.3 1.2 2.4 2 0 0 2 2 2 0 Insulin receptor trans-membrane segment Vpu PF00558.19 ELR15883.1 - 7.3 6.4 4.8 7.2 6.5 2.9 1.8 2 0 0 2 2 2 0 Vpu protein Snf7 PF03357.21 ELR15884.1 - 4e-29 101.4 30.2 5e-29 101.1 30.2 1.2 1 0 0 1 1 1 1 Snf7 YnfE PF17452.2 ELR15884.1 - 0.58 10.5 11.7 0.34 11.2 3.6 2.9 3 1 1 4 4 4 0 Uncharacterized YnfE-like Cytochrom_B562 PF07361.11 ELR15884.1 - 9.5 6.9 22.6 2.7 8.7 1.0 2.7 2 1 0 2 2 2 0 Cytochrome b562 tRNA_int_endo PF01974.17 ELR15886.1 - 4.2e-19 68.4 0.0 8.9e-19 67.4 0.0 1.5 1 0 0 1 1 1 1 tRNA intron endonuclease, catalytic C-terminal domain tRNA_int_endo_N PF02778.14 ELR15886.1 - 0.0012 18.5 0.1 0.018 14.7 0.0 2.2 2 0 0 2 2 2 1 tRNA intron endonuclease, N-terminal domain GST_C_6 PF17171.4 ELR15887.1 - 7.4e-19 67.3 0.5 1.6e-18 66.2 0.5 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Tom37 PF10568.9 ELR15887.1 - 5.3e-14 52.6 0.2 3.6e-13 49.9 0.1 2.1 1 1 1 2 2 2 1 Outer mitochondrial membrane transport complex protein GST_N_4 PF17172.4 ELR15887.1 - 1.9e-11 44.6 0.2 3e-07 31.1 0.0 2.5 1 1 1 2 2 2 2 Glutathione S-transferase N-terminal domain GST_C_2 PF13410.6 ELR15887.1 - 0.036 14.1 1.7 0.04 13.9 0.4 1.8 2 1 0 2 2 2 0 Glutathione S-transferase, C-terminal domain GATA PF00320.27 ELR15888.1 - 1.8e-14 53.0 6.9 3.3e-14 52.2 6.9 1.4 1 0 0 1 1 1 1 GATA zinc finger TRAPPC9-Trs120 PF08626.11 ELR15888.1 - 5.3 4.2 8.5 7.7 3.7 8.5 1.3 1 0 0 1 1 1 0 Transport protein Trs120 or TRAPPC9, TRAPP II complex subunit SAM_decarbox PF01536.16 ELR15889.1 - 5.1e-113 377.7 0.0 6.3e-113 377.4 0.0 1.0 1 0 0 1 1 1 1 Adenosylmethionine decarboxylase SARAF PF06682.12 ELR15890.1 - 4.3e-62 210.7 17.4 1.2e-61 209.2 17.4 1.7 1 1 0 1 1 1 1 SOCE-associated regulatory factor of calcium homoeostasis ABC_tran PF00005.27 ELR15891.1 - 8.8e-28 97.5 0.0 1.7e-27 96.6 0.0 1.4 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 ELR15891.1 - 2e-05 24.1 0.2 0.025 14.0 0.0 2.3 1 1 0 2 2 2 2 RecF/RecN/SMC N terminal domain NTPase_1 PF03266.15 ELR15891.1 - 3.8e-05 23.6 0.1 0.14 12.1 0.0 2.3 2 0 0 2 2 2 2 NTPase DUF87 PF01935.17 ELR15891.1 - 7.5e-05 22.9 0.0 0.00014 22.1 0.0 1.3 1 0 0 1 1 1 1 Helicase HerA, central domain AAA_22 PF13401.6 ELR15891.1 - 0.0014 18.9 0.3 0.015 15.6 0.3 2.2 1 1 0 1 1 1 1 AAA domain AAA_29 PF13555.6 ELR15891.1 - 0.0021 17.8 0.0 0.0061 16.3 0.0 1.8 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_16 PF13191.6 ELR15891.1 - 0.0045 17.4 0.0 0.0097 16.3 0.0 1.6 1 1 0 1 1 1 1 AAA ATPase domain G-alpha PF00503.20 ELR15891.1 - 0.0049 16.1 0.0 0.0095 15.1 0.0 1.4 1 0 0 1 1 1 1 G-protein alpha subunit FtsK_SpoIIIE PF01580.18 ELR15891.1 - 0.0055 16.1 0.0 0.01 15.2 0.0 1.3 1 0 0 1 1 1 1 FtsK/SpoIIIE family MMR_HSR1 PF01926.23 ELR15891.1 - 0.013 15.6 0.1 0.029 14.5 0.1 1.6 1 0 0 1 1 1 0 50S ribosome-binding GTPase ABC_ATPase PF09818.9 ELR15891.1 - 0.018 13.8 0.6 0.14 10.9 0.0 2.2 2 0 0 2 2 2 0 Predicted ATPase of the ABC class AAA_21 PF13304.6 ELR15891.1 - 0.019 14.8 0.1 0.1 12.3 0.0 2.1 2 0 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_30 PF13604.6 ELR15891.1 - 0.026 14.3 0.0 0.063 13.0 0.0 1.6 1 1 0 1 1 1 0 AAA domain NB-ARC PF00931.22 ELR15891.1 - 0.027 13.7 0.0 0.1 11.8 0.0 1.9 2 0 0 2 2 2 0 NB-ARC domain RsgA_GTPase PF03193.16 ELR15891.1 - 0.03 14.2 0.0 0.081 12.8 0.0 1.7 1 0 0 1 1 1 0 RsgA GTPase AAA_5 PF07728.14 ELR15891.1 - 0.033 14.2 0.1 0.18 11.8 0.0 2.2 2 1 1 3 3 3 0 AAA domain (dynein-related subfamily) DUF815 PF05673.13 ELR15891.1 - 0.069 12.3 0.0 0.12 11.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_18 PF13238.6 ELR15891.1 - 0.093 13.3 0.1 0.36 11.4 0.1 2.1 1 1 0 1 1 1 0 AAA domain RuvB_N PF05496.12 ELR15891.1 - 0.13 12.0 0.7 1.3 8.8 0.0 2.6 2 1 1 3 3 3 0 Holliday junction DNA helicase RuvB P-loop domain ABC_membrane PF00664.23 ELR15891.1 - 0.27 10.8 12.6 0.054 13.1 6.4 2.1 1 1 1 2 2 2 0 ABC transporter transmembrane region TIG PF01833.24 ELR15892.1 - 3.9e-16 58.9 1.0 8.8e-16 57.8 1.0 1.7 1 0 0 1 1 1 1 IPT/TIG domain INO80_Ies4 PF08193.11 ELR15892.1 - 0.5 10.3 4.2 0.85 9.6 4.2 1.3 1 0 0 1 1 1 0 INO80 complex subunit Ies4 HNOBA PF07701.14 ELR15893.1 - 3.1e-16 59.5 4.7 1.6e-09 37.5 0.1 3.0 2 1 1 3 3 3 2 Heme NO binding associated RasGAP PF00616.19 ELR15893.1 - 5.7e-14 52.3 0.0 1.7e-12 47.5 0.0 4.0 3 2 1 4 4 4 2 GTPase-activator protein for Ras-like GTPase TMEM51 PF15345.6 ELR15893.1 - 0.32 10.8 7.6 0.63 9.8 7.6 1.4 1 0 0 1 1 1 0 Transmembrane protein 51 DUF4887 PF16228.5 ELR15893.1 - 8.3 6.6 27.2 1.4 9.1 17.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4887) Ank_5 PF13857.6 ELR15894.1 - 1.4e-20 73.1 0.6 6.7e-11 42.2 0.0 2.4 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 ELR15894.1 - 2.9e-18 66.0 0.4 7.2e-12 45.6 0.0 2.4 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 ELR15894.1 - 3e-15 56.6 0.0 1.7e-06 28.5 0.0 2.5 2 1 1 3 3 3 2 Ankyrin repeats (3 copies) Ank PF00023.30 ELR15894.1 - 4.3e-15 55.4 0.1 1.6e-06 28.3 0.0 2.4 2 0 0 2 2 2 2 Ankyrin repeat Ank_3 PF13606.6 ELR15894.1 - 2.2e-13 49.0 0.0 8.1e-06 25.8 0.0 2.9 3 0 0 3 3 3 2 Ankyrin repeat ACBP PF00887.19 ELR15894.1 - 1.3e-11 44.6 1.9 2.1e-10 40.6 1.9 2.3 1 1 0 1 1 1 1 Acyl CoA binding protein EGF_CA PF07645.15 ELR15895.1 - 9e-75 246.6 135.7 3.3e-12 46.4 8.9 9.4 9 0 0 9 9 9 9 Calcium-binding EGF domain EGF_3 PF12947.7 ELR15895.1 - 1.9e-73 242.3 135.4 1.8e-11 44.0 7.0 9.4 9 0 0 9 9 9 9 EGF domain cEGF PF12662.7 ELR15895.1 - 1.1e-36 124.4 98.8 2e-06 27.6 7.2 10.5 10 0 0 10 10 10 9 Complement Clr-like EGF-like EGF PF00008.27 ELR15895.1 - 8.5e-27 93.1 125.0 1e-05 25.7 5.4 10.0 9 0 0 9 9 9 9 EGF-like domain hEGF PF12661.7 ELR15895.1 - 2e-23 82.1 96.6 4.6e-05 23.9 4.0 11.1 11 0 0 11 11 9 9 Human growth factor-like EGF DUF5011 PF16403.5 ELR15895.1 - 1.3e-21 76.5 1.7 7.9e-09 35.5 0.1 4.5 4 0 0 4 4 4 3 Domain of unknown function (DUF5011) EGF_MSP1_1 PF12946.7 ELR15895.1 - 1.6e-19 69.6 115.7 0.00019 21.4 7.5 9.4 9 0 0 9 9 9 7 MSP1 EGF domain 1 FXa_inhibition PF14670.6 ELR15895.1 - 3.5e-16 59.2 129.7 0.00097 19.4 7.5 9.5 8 1 1 9 9 9 8 Coagulation Factor Xa inhibitory site Plasmod_Pvs28 PF06247.11 ELR15895.1 - 1.3e-14 54.2 109.7 0.00043 20.5 7.3 9.6 9 0 0 9 9 9 7 Pvs28 EGF domain DUF4625 PF15418.6 ELR15895.1 - 0.0055 17.0 0.0 0.95 9.7 0.0 2.7 2 0 0 2 2 2 1 Domain of unknown function (DUF4625) HYR PF02494.16 ELR15895.1 - 0.02 15.2 0.3 7.6 7.0 0.0 3.3 3 0 0 3 3 3 0 HYR domain LPD34 PF18852.1 ELR15895.1 - 0.06 12.9 0.1 0.098 12.2 0.1 1.2 1 0 0 1 1 1 0 Large polyvalent protein associated domain 34 GLTP PF08718.11 ELR15896.1 - 2.8e-35 121.8 0.0 3.7e-35 121.4 0.0 1.1 1 0 0 1 1 1 1 Glycolipid transfer protein (GLTP) CW_binding_1 PF01473.20 ELR15897.1 - 0.24 11.8 5.3 0.84 10.1 0.3 2.7 3 0 0 3 3 3 0 Putative cell wall binding repeat CM_2 PF01817.21 ELR15898.1 - 1.9e-08 34.5 0.0 5.4e-08 33.1 0.0 1.7 2 0 0 2 2 2 1 Chorismate mutase type II Baculo_PEP_C PF04513.12 ELR15898.1 - 0.0091 16.0 3.1 0.019 15.0 3.0 1.6 1 1 0 1 1 1 1 Baculovirus polyhedron envelope protein, PEP, C terminus AI-2E_transport PF01594.16 ELR15898.1 - 0.045 12.9 0.4 0.067 12.3 0.4 1.2 1 0 0 1 1 1 0 AI-2E family transporter DAO_C PF16901.5 ELR15898.1 - 0.07 13.0 0.0 0.13 12.1 0.0 1.4 1 0 0 1 1 1 0 C-terminal domain of alpha-glycerophosphate oxidase Virul_fac_BrkB PF03631.15 ELR15898.1 - 0.1 12.2 4.3 0.18 11.4 4.3 1.4 1 0 0 1 1 1 0 Virulence factor BrkB Fzo_mitofusin PF04799.13 ELR15898.1 - 0.11 12.0 1.2 0.13 11.8 0.1 1.7 2 0 0 2 2 2 0 fzo-like conserved region DUF2205 PF10224.9 ELR15898.1 - 0.13 12.3 0.2 0.26 11.3 0.2 1.5 1 0 0 1 1 1 0 Short coiled-coil protein ZnuA PF01297.17 ELR15898.1 - 0.21 11.0 1.0 0.28 10.6 0.9 1.3 1 1 0 1 1 1 0 Zinc-uptake complex component A periplasmic F-box-like PF12937.7 ELR15900.1 - 4.1e-11 42.6 0.2 7.1e-11 41.8 0.2 1.4 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ELR15900.1 - 5.6e-09 35.7 0.7 1e-08 34.8 0.7 1.4 1 0 0 1 1 1 1 F-box domain SPRY PF00622.28 ELR15900.1 - 0.0036 17.4 0.1 0.0064 16.6 0.1 1.4 1 0 0 1 1 1 1 SPRY domain PCI PF01399.27 ELR15901.1 - 4e-10 40.1 0.7 8.7e-10 39.1 0.2 1.8 2 0 0 2 2 2 1 PCI domain DUF4618 PF15397.6 ELR15901.1 - 0.021 14.3 0.1 0.045 13.2 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4618) CRAL_TRIO PF00650.20 ELR15902.1 - 1.4e-15 57.4 0.1 1.7e-11 44.1 0.0 2.3 1 1 1 2 2 2 2 CRAL/TRIO domain GOLD_2 PF13897.6 ELR15902.1 - 8e-12 45.8 0.7 2.1e-05 25.0 0.1 2.5 1 1 1 2 2 2 2 Golgi-dynamics membrane-trafficking CRAL_TRIO_N PF03765.15 ELR15902.1 - 7.1e-06 26.1 0.6 1.7e-05 24.9 0.6 1.7 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain RasGAP PF00616.19 ELR15903.1 - 3.9e-23 82.2 0.0 1.2e-11 44.7 0.0 2.6 1 1 1 2 2 2 2 GTPase-activator protein for Ras-like GTPase PH PF00169.29 ELR15903.1 - 8.3e-11 42.3 0.0 1.9e-10 41.2 0.0 1.6 1 0 0 1 1 1 1 PH domain SH3_2 PF07653.17 ELR15903.1 - 8.9e-06 25.3 0.0 0.025 14.3 0.0 2.9 2 1 0 2 2 2 2 Variant SH3 domain SH3_1 PF00018.28 ELR15903.1 - 0.014 15.0 0.1 4.1 7.1 0.0 2.9 3 0 0 3 3 3 0 SH3 domain DUF3104 PF11302.8 ELR15903.1 - 0.014 15.1 0.0 0.34 10.7 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3104) PH_9 PF15410.6 ELR15903.1 - 0.12 12.8 0.4 0.36 11.2 0.0 2.0 2 0 0 2 2 2 0 Pleckstrin homology domain PH_8 PF15409.6 ELR15903.1 - 0.12 12.7 0.1 2.3 8.6 0.0 2.4 2 0 0 2 2 2 0 Pleckstrin homology domain Ost4 PF10215.9 ELR15904.1 - 3.8e-13 49.0 0.8 4.1e-13 48.9 0.8 1.0 1 0 0 1 1 1 1 Oligosaccaryltransferase Form-deh_trans PF09163.11 ELR15904.1 - 0.0048 16.6 0.0 0.0052 16.5 0.0 1.2 1 0 0 1 1 1 1 Formate dehydrogenase N, transmembrane SIMPL PF04402.14 ELR15905.1 - 5.1e-28 98.9 11.2 6e-28 98.7 11.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF541) Mito_carr PF00153.27 ELR15905.1 - 0.082 12.8 0.3 0.17 11.8 0.3 1.5 1 0 0 1 1 1 0 Mitochondrial carrier protein LIM PF00412.22 ELR15906.1 - 1.1e-15 57.6 34.8 0.17 12.1 0.3 9.6 9 0 0 9 9 9 8 LIM domain NTP_transf_3 PF12804.7 ELR15906.1 - 1.4e-05 25.5 8.7 2.1 8.7 0.0 6.2 1 1 5 6 6 6 2 MobA-like NTP transferase domain zf-TFIIB PF13453.6 ELR15906.1 - 4e-05 22.9 39.2 0.18 11.2 1.6 9.1 8 2 2 10 10 10 6 Transcription factor zinc-finger PT PF04886.12 ELR15906.1 - 0.00014 21.3 17.1 6.5 6.4 0.2 7.8 9 0 0 9 9 9 2 PT repeat zf-C4_Topoisom PF01396.19 ELR15906.1 - 0.00018 21.2 49.1 6.6 6.6 0.2 9.9 9 1 1 10 10 10 8 Topoisomerase DNA binding C4 zinc finger PhnA_Zn_Ribbon PF08274.12 ELR15906.1 - 0.00033 20.6 35.5 4.7 7.3 0.0 9.0 9 0 0 9 9 9 2 PhnA Zinc-Ribbon zinc_ribbon_2 PF13240.6 ELR15906.1 - 0.0041 16.8 6.0 0.0041 16.8 6.0 6.3 10 0 0 10 10 10 1 zinc-ribbon domain DZR PF12773.7 ELR15906.1 - 0.0086 16.1 1.9 0.0086 16.1 1.9 7.7 4 2 1 5 5 5 1 Double zinc ribbon zf_Rg PF17915.1 ELR15906.1 - 0.48 9.9 35.8 23 4.5 0.1 8.7 8 1 1 9 9 9 0 Reverse gyrase zinc finger Prok-RING_1 PF14446.6 ELR15906.1 - 2.9 7.9 78.8 0.29 11.1 0.4 12.4 11 2 2 13 13 13 0 Prokaryotic RING finger family 1 CW_binding_1 PF01473.20 ELR15907.1 - 0.056 13.8 4.4 0.65 10.4 0.3 3.0 3 0 0 3 3 3 0 Putative cell wall binding repeat COPIIcoated_ERV PF07970.12 ELR15909.1 - 1.2e-32 113.6 0.0 1.6e-32 113.1 0.0 1.1 1 0 0 1 1 1 1 Endoplasmic reticulum vesicle transporter ERGIC_N PF13850.6 ELR15909.1 - 9.8e-19 67.5 0.3 3.6e-18 65.7 0.0 1.9 2 0 0 2 2 2 1 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) Rad52_Rad22 PF04098.15 ELR15910.1 - 1e-23 83.9 0.4 1.5e-23 83.4 0.4 1.2 1 0 0 1 1 1 1 Rad52/22 family double-strand break repair protein PhyH PF05721.13 ELR15911.1 - 6.2e-15 56.0 0.0 2.5e-14 54.0 0.0 1.7 1 1 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) Engrail_1_C_sig PF10525.9 ELR15911.1 - 3.2 7.0 4.7 0.88 8.9 1.5 1.7 2 0 0 2 2 2 0 Engrailed homeobox C-terminal signature domain RskA PF10099.9 ELR15912.1 - 0.0025 18.1 6.1 0.0034 17.7 6.1 1.2 1 0 0 1 1 1 1 Anti-sigma-K factor rskA AT_hook PF02178.19 ELR15912.1 - 0.004 16.9 37.2 0.15 12.0 2.7 4.7 4 0 0 4 4 4 3 AT hook motif Vps51 PF08700.11 ELR15912.1 - 0.0061 16.6 0.3 0.0088 16.1 0.3 1.2 1 0 0 1 1 1 1 Vps51/Vps67 Shadoo PF14999.6 ELR15912.1 - 0.0063 16.6 3.6 0.0083 16.2 3.6 1.2 1 0 0 1 1 1 1 Shadow of prion protein, neuroprotective TolA_bind_tri PF16331.5 ELR15912.1 - 0.027 14.5 1.2 0.04 14.0 1.2 1.3 1 0 0 1 1 1 0 TolA binding protein trimerisation ATG16 PF08614.11 ELR15912.1 - 0.046 13.9 2.6 0.059 13.6 2.6 1.3 1 1 0 1 1 1 0 Autophagy protein 16 (ATG16) Sec2p PF06428.11 ELR15912.1 - 0.061 13.3 1.1 0.089 12.8 1.1 1.3 1 0 0 1 1 1 0 GDP/GTP exchange factor Sec2p K_channel_TID PF07941.11 ELR15912.1 - 0.069 13.6 6.3 0.14 12.7 6.3 1.4 1 0 0 1 1 1 0 Potassium channel Kv1.4 tandem inactivation domain DUF3138 PF11336.8 ELR15912.1 - 8.7 4.8 7.1 1.3 7.5 0.4 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3138) SNARE_assoc PF09335.11 ELR15913.1 - 1.6e-18 67.3 8.9 4.8e-17 62.6 9.6 2.4 2 1 0 2 2 2 1 SNARE associated Golgi protein UPF0242 PF06785.11 ELR15913.1 - 0.0097 16.0 0.1 0.016 15.4 0.1 1.3 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0242) N-terminus Vta1 PF04652.16 ELR15913.1 - 0.028 14.4 1.8 0.055 13.4 1.8 1.4 1 0 0 1 1 1 0 Vta1 like AAA_23 PF13476.6 ELR15913.1 - 0.029 14.9 1.3 0.044 14.3 1.3 1.2 1 0 0 1 1 1 0 AAA domain Cytadhesin_P30 PF07271.11 ELR15913.1 - 0.089 12.3 0.8 0.14 11.7 0.8 1.2 1 0 0 1 1 1 0 Cytadhesin P30/P32 MRP-S26 PF14943.6 ELR15913.1 - 3.1 7.7 13.6 4.4 7.2 13.6 1.1 1 0 0 1 1 1 0 Mitochondrial ribosome subunit S26 DUF2681 PF10883.8 ELR15913.1 - 5.2 7.5 7.8 63 4.1 7.8 2.5 1 1 0 1 1 1 0 Protein of unknown function (DUF2681) MPP6 PF10175.9 ELR15914.1 - 5.5e-17 62.5 16.4 4.3e-15 56.4 16.4 2.1 1 1 0 1 1 1 1 M-phase phosphoprotein 6 CDC45 PF02724.14 ELR15914.1 - 3.6 5.8 9.1 3.4 5.8 9.1 1.2 1 0 0 1 1 1 0 CDC45-like protein Erythro_esteras PF05139.14 ELR15915.1 - 9e-91 305.2 4.4 1.1e-90 305.0 4.4 1.1 1 0 0 1 1 1 1 Erythromycin esterase Lipase_GDSL_2 PF13472.6 ELR15915.1 - 0.0063 16.9 0.0 0.014 15.8 0.0 1.6 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family G8 PF10162.9 ELR15916.1 - 2.2e-19 69.7 0.0 5.9e-19 68.4 0.0 1.8 1 0 0 1 1 1 1 G8 domain Diphthamide_syn PF01866.17 ELR15917.1 - 7.4e-109 363.8 0.0 2.5e-108 362.1 0.0 1.7 1 1 0 1 1 1 1 Putative diphthamide synthesis protein ZapB PF06005.12 ELR15918.1 - 0.014 15.8 1.5 0.014 15.8 1.5 2.3 2 0 0 2 2 2 0 Cell division protein ZapB DivIC PF04977.15 ELR15918.1 - 0.025 14.3 0.6 0.076 12.8 0.6 1.7 1 0 0 1 1 1 0 Septum formation initiator YabA PF06156.13 ELR15918.1 - 0.064 13.9 0.9 0.2 12.3 0.2 2.1 2 0 0 2 2 2 0 Initiation control protein YabA DsbB PF02600.16 ELR15918.1 - 0.11 12.9 0.1 0.2 12.1 0.1 1.3 1 0 0 1 1 1 0 Disulfide bond formation protein DsbB zf-GRF PF06839.12 ELR15918.1 - 0.18 12.0 0.1 0.39 10.8 0.1 1.5 1 0 0 1 1 1 0 GRF zinc finger DUF3450 PF11932.8 ELR15918.1 - 0.24 10.7 3.2 0.52 9.6 0.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) HALZ PF02183.18 ELR15918.1 - 0.26 11.6 0.9 0.78 10.0 0.8 1.9 1 1 0 1 1 1 0 Homeobox associated leucine zipper DUF3847 PF12958.7 ELR15918.1 - 0.46 10.6 4.5 1.2 9.3 4.5 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3847) DUF4055 PF13264.6 ELR15918.1 - 2.5 8.3 8.5 18 5.5 0.1 3.7 3 0 0 3 3 3 0 Domain of unknown function (DUF4055) APG6_N PF17675.1 ELR15918.1 - 9.8 6.7 10.6 1.1 9.8 5.7 2.0 2 0 0 2 2 2 0 Apg6 coiled-coil region Bystin PF05291.11 ELR15919.1 - 2.2e-130 434.2 2.6 2.5e-130 434.0 2.6 1.0 1 0 0 1 1 1 1 Bystin CDP-OH_P_transf PF01066.21 ELR15920.1 - 2.5e-14 53.8 0.2 2.5e-14 53.8 0.2 2.5 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase Nup188 PF10487.9 ELR15921.1 - 8.3e-38 129.9 6.0 1.9e-21 75.8 0.4 3.0 1 1 2 3 3 3 3 Nucleoporin subcomplex protein binding to Pom34 Nup192 PF11894.8 ELR15921.1 - 2.2e-10 38.4 6.2 5.3e-06 23.9 1.1 2.1 2 0 0 2 2 2 2 Nuclear pore complex scaffold, nucleoporins 186/192/205 TerB PF05099.13 ELR15921.1 - 0.00051 20.0 1.3 0.0012 18.9 1.3 1.5 1 0 0 1 1 1 1 Tellurite resistance protein TerB Nup188 PF10487.9 ELR15922.1 - 6e-11 41.0 0.0 1.1e-10 40.1 0.0 1.4 1 0 0 1 1 1 1 Nucleoporin subcomplex protein binding to Pom34 Nup192 PF11894.8 ELR15922.1 - 1.3e-08 32.5 0.0 1.7e-08 32.2 0.0 1.0 1 0 0 1 1 1 1 Nuclear pore complex scaffold, nucleoporins 186/192/205 DprA_WH PF17782.1 ELR15922.1 - 0.023 14.8 2.1 1.6 8.9 0.1 2.7 2 1 1 3 3 3 0 DprA winged helix domain Pkinase PF00069.25 ELR15923.1 - 5.6e-43 147.2 0.0 8.9e-43 146.5 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR15923.1 - 6.9e-32 110.7 0.0 7.1e-31 107.4 0.0 2.1 2 0 0 2 2 2 1 Protein tyrosine kinase PX PF00787.24 ELR15923.1 - 1.3e-17 63.8 0.2 3e-17 62.6 0.2 1.6 1 0 0 1 1 1 1 PX domain Pkinase_fungal PF17667.1 ELR15923.1 - 0.028 13.2 0.2 0.06 12.1 0.0 1.6 2 0 0 2 2 2 0 Fungal protein kinase FH2 PF02181.23 ELR15924.1 - 2.6e-64 217.7 5.3 2.6e-64 217.7 5.3 3.1 3 0 0 3 3 3 2 Formin Homology 2 Domain Drf_FH3 PF06367.16 ELR15924.1 - 3.5e-23 82.3 0.4 3.5e-23 82.3 0.4 3.2 3 0 0 3 3 3 1 Diaphanous FH3 Domain Drf_GBD PF06371.13 ELR15924.1 - 1.5e-15 57.3 0.1 1.5e-15 57.3 0.1 3.0 2 0 0 2 2 2 1 Diaphanous GTPase-binding Domain GAGA_bind PF06217.12 ELR15924.1 - 0.97 9.7 10.9 3.4 7.9 10.9 1.9 1 0 0 1 1 1 0 GAGA binding protein-like family RasGEF PF00617.19 ELR15925.1 - 1.5e-40 139.3 2.0 3e-40 138.3 2.0 1.5 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 ELR15925.1 - 1.1e-32 112.3 0.4 2.5e-32 111.3 0.1 1.7 2 0 0 2 2 2 1 RasGEF N-terminal motif ALG3 PF05208.13 ELR15927.1 - 4.2e-74 250.1 6.4 1.3e-43 149.8 2.2 2.1 1 1 1 2 2 2 2 ALG3 protein EF-hand_6 PF13405.6 ELR15927.1 - 0.00024 20.8 0.1 0.00059 19.6 0.1 1.6 1 0 0 1 1 1 1 EF-hand domain EF-hand_1 PF00036.32 ELR15927.1 - 0.0038 16.7 0.1 0.008 15.7 0.1 1.6 1 0 0 1 1 1 1 EF hand EF-hand_7 PF13499.6 ELR15927.1 - 0.026 15.0 0.0 0.046 14.2 0.0 1.4 1 0 0 1 1 1 0 EF-hand domain pair PLDc_N PF13396.6 ELR15927.1 - 1.5 8.8 0.0 1.5 8.8 0.0 2.7 2 0 0 2 2 2 0 Phospholipase_D-nuclease N-terminal DUF2079 PF09852.9 ELR15927.1 - 4.5 6.0 14.2 0.055 12.3 6.4 1.6 2 0 0 2 2 2 0 Predicted membrane protein (DUF2079) eIF-5a PF01287.20 ELR15929.1 - 1.5e-24 85.9 1.0 2.2e-24 85.3 1.0 1.3 1 0 0 1 1 1 1 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold EFP_N PF08207.12 ELR15929.1 - 0.00047 20.1 0.1 0.00068 19.6 0.1 1.3 1 0 0 1 1 1 1 Elongation factor P (EF-P) KOW-like domain SNase PF00565.17 ELR15930.1 - 2.2e-44 150.3 14.3 1.1e-09 38.8 0.3 6.6 5 1 1 6 6 6 5 Staphylococcal nuclease homologue TUDOR PF00567.24 ELR15930.1 - 1.1e-21 77.2 0.0 2.6e-21 75.9 0.0 1.5 1 0 0 1 1 1 1 Tudor domain SPOR PF05036.13 ELR15930.1 - 0.0068 16.8 0.2 0.05 14.0 0.2 2.7 1 0 0 1 1 1 1 Sporulation related domain Agenet PF05641.12 ELR15930.1 - 0.11 13.0 0.1 2.8 8.5 0.0 2.6 2 0 0 2 2 2 0 Agenet domain EamA PF00892.20 ELR15931.1 - 4.6e-06 26.8 4.6 4.6e-06 26.8 4.6 2.0 2 0 0 2 2 2 1 EamA-like transporter family Sugar_transport PF06800.12 ELR15931.1 - 0.042 13.2 2.2 0.077 12.3 2.2 1.3 1 0 0 1 1 1 0 Sugar transport protein Erf4 PF10256.9 ELR15932.1 - 0.0043 17.1 0.0 0.0066 16.5 0.0 1.3 1 0 0 1 1 1 1 Golgin subfamily A member 7/ERF4 family Pkinase_Tyr PF07714.17 ELR15933.1 - 4.2e-65 219.6 0.0 5.7e-65 219.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ELR15933.1 - 2.8e-43 148.2 0.0 5e-43 147.4 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_fungal PF17667.1 ELR15933.1 - 1.5e-05 24.0 0.4 2.6e-05 23.2 0.0 1.5 2 0 0 2 2 2 1 Fungal protein kinase Kdo PF06293.14 ELR15933.1 - 0.0011 18.3 0.0 0.0027 17.1 0.0 1.6 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 ELR15933.1 - 0.002 17.5 0.0 0.003 16.9 0.0 1.3 1 0 0 1 1 1 1 Kinase-like FTA2 PF13095.6 ELR15933.1 - 0.014 15.1 0.0 5.7 6.5 0.1 2.3 1 1 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 APH PF01636.23 ELR15933.1 - 0.028 14.4 0.6 0.11 12.4 0.0 2.1 2 0 0 2 2 2 0 Phosphotransferase enzyme family Gly-zipper_Omp PF13488.6 ELR15933.1 - 0.039 13.9 3.4 0.11 12.5 3.4 1.7 1 0 0 1 1 1 0 Glycine zipper Haspin_kinase PF12330.8 ELR15933.1 - 0.081 11.8 0.1 0.17 10.8 0.1 1.4 1 0 0 1 1 1 0 Haspin like kinase domain ABC_trans_aux PF03886.13 ELR15933.1 - 0.092 12.3 0.0 0.16 11.5 0.0 1.3 1 0 0 1 1 1 0 ABC-type transport auxiliary lipoprotein component Gly-zipper_OmpA PF13436.6 ELR15933.1 - 0.34 10.7 5.0 1 9.2 5.0 1.8 1 0 0 1 1 1 0 Glycine-zipper domain SPT6_acidic PF14632.6 ELR15933.1 - 0.46 11.1 12.2 1 10.0 12.2 1.5 1 0 0 1 1 1 0 Acidic N-terminal SPT6 MAP17 PF15807.5 ELR15933.1 - 0.9 9.8 4.5 3.5 7.9 0.0 2.7 2 1 1 3 3 3 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 Vpu PF00558.19 ELR15933.1 - 1.2 8.9 3.4 15 5.5 1.1 2.6 2 0 0 2 2 2 0 Vpu protein DUF3381 PF11861.8 ELR15933.1 - 4.9 6.9 10.5 8.2 6.2 10.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3381) Laminin_G_3 PF13385.6 ELR15934.1 - 4.2e-17 62.7 3.2 9.8e-17 61.5 3.2 1.6 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Peptidase_M20 PF01546.28 ELR15935.1 - 2.7e-38 131.8 0.0 4.2e-38 131.1 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 ELR15935.1 - 2.9e-18 65.8 0.1 1.3e-17 63.7 0.0 2.0 2 0 0 2 2 2 1 Peptidase dimerisation domain Peptidase_M28 PF04389.17 ELR15935.1 - 2.4e-06 27.4 0.0 4.5e-06 26.5 0.0 1.5 1 0 0 1 1 1 1 Peptidase family M28 Peptidase_M42 PF05343.14 ELR15935.1 - 0.0013 17.8 0.0 0.0029 16.7 0.0 1.5 1 0 0 1 1 1 1 M42 glutamyl aminopeptidase MDMPI_N PF11716.8 ELR15935.1 - 0.006 17.3 6.3 0.016 15.9 6.3 1.7 1 0 0 1 1 1 1 Mycothiol maleylpyruvate isomerase N-terminal domain DUF3592 PF12158.8 ELR15935.1 - 0.071 13.2 0.4 0.12 12.4 0.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3592) Gln_amidase PF15644.6 ELR15935.1 - 0.11 13.5 0.0 0.25 12.4 0.0 1.5 1 0 0 1 1 1 0 Papain fold toxin 1, glutamine deamidase MRP-L47 PF06984.13 ELR15936.1 - 3.3e-25 88.0 0.5 3.3e-25 88.0 0.5 1.6 2 1 0 2 2 2 1 Mitochondrial 39-S ribosomal protein L47 (MRP-L47) Ribosomal_L29 PF00831.23 ELR15936.1 - 1e-06 28.6 3.6 1e-06 28.6 3.6 1.7 2 0 0 2 2 2 1 Ribosomal L29 protein LRR_8 PF13855.6 ELR15937.1 - 1.1e-12 47.5 7.0 1.9e-10 40.3 2.5 2.6 2 1 1 3 3 3 2 Leucine rich repeat LRR_4 PF12799.7 ELR15937.1 - 1.4e-12 47.6 2.5 2.2e-06 27.9 1.4 3.0 3 0 0 3 3 3 2 Leucine Rich repeats (2 copies) SAM_1 PF00536.30 ELR15937.1 - 1.2e-09 38.4 0.0 2.6e-09 37.4 0.0 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 ELR15937.1 - 2.1e-07 30.9 0.0 6e-07 29.5 0.0 1.8 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) LRR_9 PF14580.6 ELR15937.1 - 9.9e-05 21.9 0.1 0.00018 21.1 0.1 1.3 1 0 0 1 1 1 1 Leucine-rich repeat SAM_PNT PF02198.16 ELR15937.1 - 0.00011 22.2 0.0 0.00021 21.2 0.0 1.4 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain LRR_1 PF00560.33 ELR15937.1 - 0.00015 21.8 6.9 0.73 10.6 0.3 4.6 4 0 0 4 4 4 2 Leucine Rich Repeat Ras PF00071.22 ELR15937.1 - 0.0055 16.3 0.0 0.0089 15.6 0.0 1.4 1 0 0 1 1 1 1 Ras family SAM_3 PF18016.1 ELR15937.1 - 0.19 11.6 0.0 0.59 10.0 0.0 1.8 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) LRR_6 PF13516.6 ELR15937.1 - 1.9 8.7 8.4 1.4 9.1 0.1 3.8 4 0 0 4 4 4 0 Leucine Rich repeat DUF569 PF04601.13 ELR15938.1 - 0.00012 21.8 0.0 0.00017 21.3 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF569) FRG1 PF06229.12 ELR15938.1 - 0.074 12.8 0.0 0.099 12.3 0.0 1.1 1 0 0 1 1 1 0 FRG1-like domain RFX_DNA_binding PF02257.15 ELR15940.1 - 1.4e-05 25.6 0.3 1.7e-05 25.4 0.3 1.1 1 0 0 1 1 1 1 RFX DNA-binding domain TnsD PF15978.5 ELR15942.1 - 0.012 14.6 3.4 0.012 14.6 3.4 2.0 1 1 1 2 2 2 0 Tn7-like transposition protein D PKcGMP_CC PF16808.5 ELR15942.1 - 0.022 14.6 3.3 0.022 14.6 3.3 4.3 3 2 0 3 3 3 0 Coiled-coil N-terminus of cGMP-dependent protein kinase DUF1515 PF07439.11 ELR15942.1 - 0.57 10.2 14.1 0.077 13.0 5.1 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1515) DUF3584 PF12128.8 ELR15942.1 - 0.96 6.9 30.8 1.1 6.7 30.8 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) FUSC PF04632.12 ELR15942.1 - 1.1 7.7 14.2 0.45 9.0 11.7 1.5 1 1 0 1 1 1 0 Fusaric acid resistance protein family TPR_MLP1_2 PF07926.12 ELR15942.1 - 1.4 9.0 37.3 0.25 11.4 5.1 2.1 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein Borrelia_P83 PF05262.11 ELR15942.1 - 1.4 7.3 27.9 1.7 7.1 27.9 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein OmpH PF03938.14 ELR15942.1 - 1.5 9.1 33.7 2.6 8.4 27.7 2.1 1 1 1 2 2 2 0 Outer membrane protein (OmpH-like) TMF_DNA_bd PF12329.8 ELR15942.1 - 2.2 8.4 34.4 3.9 7.5 2.2 2.8 1 1 2 3 3 3 0 TATA element modulatory factor 1 DNA binding Fib_alpha PF08702.10 ELR15942.1 - 2.5 8.3 12.6 1.4 9.1 10.7 1.5 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family DUF4407 PF14362.6 ELR15942.1 - 2.9 7.2 24.5 4 6.7 24.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) F-protein PF00469.20 ELR15942.1 - 2.9 7.4 12.7 3.8 7.0 12.4 1.3 1 1 0 1 1 1 0 Negative factor, (F-Protein) or Nef Golgin_A5 PF09787.9 ELR15942.1 - 5.6 6.3 28.6 19 4.6 28.6 1.8 1 1 0 1 1 1 0 Golgin subfamily A member 5 Fmp27_WPPW PF10359.9 ELR15942.1 - 8.3 5.1 23.3 21 3.8 23.3 1.6 1 1 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain DDHD PF02862.17 ELR15942.1 - 8.3 6.5 11.0 10 6.2 11.0 1.2 1 0 0 1 1 1 0 DDHD domain SPRY PF00622.28 ELR15943.1 - 5.5e-16 58.8 0.0 1.3e-15 57.5 0.0 1.6 2 0 0 2 2 2 1 SPRY domain BUD22 PF09073.10 ELR15943.1 - 0.024 14.0 13.6 0.037 13.4 13.6 1.2 1 0 0 1 1 1 0 BUD22 CAAD PF14159.6 ELR15943.1 - 0.05 13.4 0.0 0.83 9.5 0.0 2.7 3 0 0 3 3 3 0 CAAD domains of cyanobacterial aminoacyl-tRNA synthetase RNA_pol_3_Rpc31 PF11705.8 ELR15943.1 - 0.065 13.5 14.0 0.12 12.6 14.0 1.4 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 FYDLN_acid PF09538.10 ELR15943.1 - 0.17 12.6 10.8 0.41 11.3 10.8 1.6 1 0 0 1 1 1 0 Protein of unknown function (FYDLN_acid) Vfa1 PF08432.10 ELR15943.1 - 0.44 10.9 6.3 0.84 9.9 6.3 1.4 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Nop25 PF09805.9 ELR15943.1 - 0.53 10.7 14.2 1.2 9.6 14.2 1.6 1 0 0 1 1 1 0 Nucleolar protein 12 (25kDa) Cwf_Cwc_15 PF04889.12 ELR15943.1 - 0.61 9.8 20.0 1 9.0 20.0 1.3 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein CENP-B_dimeris PF09026.10 ELR15943.1 - 3.7 8.0 16.2 9.3 6.7 16.2 1.7 1 0 0 1 1 1 0 Centromere protein B dimerisation domain DUF2457 PF10446.9 ELR15943.1 - 3.8 6.6 24.9 7.8 5.5 24.9 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) RXT2_N PF08595.11 ELR15943.1 - 4 7.4 10.3 8 6.5 10.3 1.5 1 0 0 1 1 1 0 RXT2-like, N-terminal Nop14 PF04147.12 ELR15943.1 - 7.5 4.6 19.5 11 4.1 19.5 1.1 1 0 0 1 1 1 0 Nop14-like family Pox_Ag35 PF03286.14 ELR15943.1 - 8 6.2 11.5 15 5.3 11.5 1.4 1 0 0 1 1 1 0 Pox virus Ag35 surface protein DUF4746 PF15928.5 ELR15943.1 - 8.1 5.8 10.1 13 5.1 10.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Nop53 PF07767.11 ELR15943.1 - 8.2 5.7 17.1 13 5.1 17.1 1.2 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) LapA_dom PF06305.11 ELR15944.1 - 0.012 15.4 0.9 5.4 6.9 0.0 2.7 3 0 0 3 3 3 0 Lipopolysaccharide assembly protein A domain T2SSM PF04612.12 ELR15944.1 - 0.2 11.7 1.2 0.27 11.3 0.0 1.7 2 0 0 2 2 2 0 Type II secretion system (T2SS), protein M Aminotran_3 PF00202.21 ELR15946.1 - 1.2e-109 366.7 0.0 1.3e-109 366.5 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III DNA_ligase_IV PF11411.8 ELR15946.1 - 0.17 12.0 0.0 0.35 11.0 0.0 1.5 1 0 0 1 1 1 0 DNA ligase IV Pro-kuma_activ PF09286.11 ELR15947.1 - 5.5e-20 72.1 0.0 9e-20 71.4 0.0 1.3 1 0 0 1 1 1 1 Pro-kumamolisin, activation domain Peptidase_S8 PF00082.22 ELR15947.1 - 0.00059 19.2 0.2 0.0012 18.2 0.2 1.5 1 0 0 1 1 1 1 Subtilase family Hydrolase PF00702.26 ELR15949.1 - 1.5e-08 35.2 0.0 3.3e-08 34.1 0.0 1.6 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 ELR15949.1 - 4.4e-08 33.1 0.0 1.1e-07 31.8 0.0 1.6 1 0 0 1 1 1 1 HAD-hyrolase-like HAD_2 PF13419.6 ELR15949.1 - 2.5e-07 31.0 0.0 8.6e-07 29.2 0.0 1.8 2 0 0 2 2 2 1 Haloacid dehalogenase-like hydrolase Hydrolase_6 PF13344.6 ELR15949.1 - 0.04 14.0 0.0 0.4 10.8 0.0 2.5 2 2 0 2 2 2 0 Haloacid dehalogenase-like hydrolase DUF2757 PF10955.8 ELR15950.1 - 0.089 13.1 0.1 0.27 11.5 0.1 2.0 2 1 0 2 2 2 0 Protein of unknown function (DUF2757) DUF3386 PF11866.8 ELR15950.1 - 0.11 12.0 0.0 2.3 7.7 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3386) Pkinase_Tyr PF07714.17 ELR15951.1 - 7e-47 159.9 0.7 6.7e-43 146.8 0.1 2.8 2 1 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 ELR15951.1 - 5.6e-37 127.5 0.0 4.4e-35 121.3 0.0 2.6 2 1 0 2 2 2 1 Protein kinase domain SH2 PF00017.24 ELR15951.1 - 1.1e-06 28.6 0.0 2e-06 27.8 0.0 1.5 1 0 0 1 1 1 1 SH2 domain Pkinase_fungal PF17667.1 ELR15951.1 - 0.00049 19.0 0.0 0.00097 18.0 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase Cbl_N2 PF02761.14 ELR15951.1 - 0.086 13.6 1.8 0.3 11.8 0.4 2.6 2 1 0 2 2 2 0 CBL proto-oncogene N-terminus, EF hand-like domain Synaphin PF05835.12 ELR15951.1 - 4.5 7.6 14.9 15 5.9 14.9 1.8 1 0 0 1 1 1 0 Synaphin protein PP2C PF00481.21 ELR15952.1 - 1.7e-29 103.3 1.6 1.7e-28 100.0 0.0 3.4 3 1 0 3 3 3 1 Protein phosphatase 2C SAP PF02037.27 ELR15952.1 - 6.3e-11 41.8 3.1 1.4e-10 40.7 3.1 1.6 1 0 0 1 1 1 1 SAP domain PP2C_2 PF13672.6 ELR15952.1 - 5.5e-05 22.9 0.4 5.5e-05 22.9 0.4 2.7 3 0 0 3 3 3 1 Protein phosphatase 2C HeH PF12949.7 ELR15952.1 - 0.11 12.2 0.4 0.28 10.9 0.4 1.8 1 0 0 1 1 1 0 HeH/LEM domain Sel1 PF08238.12 ELR15953.1 - 9e-90 293.1 61.0 3.2e-09 37.2 1.5 12.1 12 0 0 12 12 12 12 Sel1 repeat TPR_2 PF07719.17 ELR15953.1 - 0.0004 20.3 0.1 0.0004 20.3 0.1 9.8 13 0 0 13 13 13 2 Tetratricopeptide repeat TPR_1 PF00515.28 ELR15953.1 - 0.00068 19.4 0.1 0.00068 19.4 0.1 9.5 13 0 0 13 13 13 3 Tetratricopeptide repeat TPR_16 PF13432.6 ELR15953.1 - 0.012 16.2 18.4 3 8.6 0.4 5.7 4 2 2 7 7 7 0 Tetratricopeptide repeat TPR_7 PF13176.6 ELR15953.1 - 0.043 13.9 14.2 1.9 8.7 0.0 7.0 8 0 0 8 8 8 0 Tetratricopeptide repeat TPR_11 PF13414.6 ELR15953.1 - 0.11 12.2 20.6 0.31 10.8 0.0 6.7 7 2 0 7 7 7 0 TPR repeat DUF1681 PF07933.14 ELR15954.1 - 0.00053 19.7 0.0 0.00078 19.2 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1681) WH1 PF00568.23 ELR15954.1 - 0.017 15.0 0.0 0.031 14.2 0.0 1.4 1 0 0 1 1 1 0 WH1 domain Mito_carr PF00153.27 ELR15955.1 - 1.5e-61 204.3 1.3 1.5e-22 79.3 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein CBM49 PF09478.10 ELR15956.1 - 3.7e-27 94.5 4.6 9.8e-13 48.2 0.1 3.2 3 0 0 3 3 3 3 Carbohydrate binding domain CBM49 CBM_2 PF00553.19 ELR15956.1 - 1.3e-10 41.5 17.3 3.2e-06 27.4 1.9 4.3 3 1 1 4 4 4 2 Cellulose binding domain DUF4352 PF11611.8 ELR15956.1 - 0.0021 18.3 0.1 0.86 9.9 0.0 2.5 2 0 0 2 2 2 2 Domain of unknown function (DUF4352) CarboxypepD_reg PF13620.6 ELR15956.1 - 0.0026 18.0 0.4 0.57 10.5 0.1 3.6 3 1 0 3 3 3 1 Carboxypeptidase regulatory-like domain DUF4402 PF14352.6 ELR15956.1 - 0.9 10.2 8.9 0.16 12.6 1.9 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4402) DUF11 PF01345.18 ELR15956.1 - 3.5 8.0 8.9 1.3 9.4 0.1 3.8 3 1 1 4 4 4 0 Domain of unknown function DUF11 CBS PF00571.28 ELR15957.1 - 2.9e-16 59.7 0.4 4.1e-07 30.3 0.0 4.4 4 0 0 4 4 4 4 CBS domain Acetyltransf_2 PF00797.17 ELR15958.1 - 2.7e-16 60.1 0.0 2.5e-11 43.9 0.0 2.1 2 0 0 2 2 2 2 N-acetyltransferase MutS_V PF00488.21 ELR15959.1 - 1.1e-84 283.2 0.7 1.1e-83 279.9 0.3 2.4 2 0 0 2 2 2 1 MutS domain V MutS_III PF05192.18 ELR15959.1 - 2.7e-32 112.6 2.7 2.7e-32 112.6 2.7 2.3 2 0 0 2 2 2 1 MutS domain III MutS_II PF05188.17 ELR15959.1 - 1.2e-15 58.0 0.1 4.1e-15 56.3 0.1 2.0 1 0 0 1 1 1 1 MutS domain II MutS_I PF01624.20 ELR15959.1 - 1.6e-06 28.3 0.2 6.1e-06 26.5 0.1 2.1 2 0 0 2 2 2 1 MutS domain I MutS_IV PF05190.18 ELR15959.1 - 0.00076 19.8 0.2 0.0026 18.1 0.2 2.0 1 0 0 1 1 1 1 MutS family domain IV LMBR1 PF04791.16 ELR15959.1 - 0.54 9.1 1.4 0.61 8.9 0.4 1.6 1 1 0 1 1 1 0 LMBR1-like membrane protein RsgA_GTPase PF03193.16 ELR15960.1 - 0.00072 19.5 0.2 0.2 11.5 0.1 2.3 2 0 0 2 2 2 2 RsgA GTPase G-alpha PF00503.20 ELR15960.1 - 0.016 14.4 0.0 0.27 10.3 0.0 2.0 2 0 0 2 2 2 0 G-protein alpha subunit PduV-EutP PF10662.9 ELR15960.1 - 0.036 13.8 0.0 2.1 8.1 0.0 2.2 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Arf PF00025.21 ELR15960.1 - 0.053 13.0 0.0 0.11 11.9 0.0 1.5 1 0 0 1 1 1 0 ADP-ribosylation factor family ATP_bind_1 PF03029.17 ELR15960.1 - 0.055 13.2 0.1 5.9 6.6 0.0 2.2 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein bZIP_2 PF07716.15 ELR15961.1 - 0.0018 18.3 2.7 0.0036 17.4 2.2 1.7 1 1 1 2 2 2 1 Basic region leucine zipper UPF0242 PF06785.11 ELR15961.1 - 0.044 13.9 0.2 0.063 13.4 0.2 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus HAUS6_N PF14661.6 ELR15961.1 - 0.064 12.8 0.3 0.1 12.2 0.3 1.2 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus Seryl_tRNA_N PF02403.22 ELR15961.1 - 0.1 12.8 2.2 0.17 12.2 2.2 1.3 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain HALZ PF02183.18 ELR15961.1 - 0.38 11.0 5.5 0.099 12.9 1.0 2.1 2 0 0 2 2 2 0 Homeobox associated leucine zipper DivIC PF04977.15 ELR15961.1 - 2.3 8.0 5.8 9.4 6.1 5.4 2.1 1 1 0 1 1 1 0 Septum formation initiator LRR_8 PF13855.6 ELR15962.1 - 6.8e-14 51.4 21.6 0.00015 21.4 3.7 5.2 4 2 0 5 5 5 4 Leucine rich repeat LRR_4 PF12799.7 ELR15962.1 - 1.6e-06 28.3 26.5 0.11 13.0 1.8 6.5 4 2 1 6 6 6 5 Leucine Rich repeats (2 copies) TRP PF06011.12 ELR15962.1 - 0.023 13.5 0.0 0.042 12.6 0.0 1.5 1 0 0 1 1 1 0 Transient receptor potential (TRP) ion channel MBOAT PF03062.19 ELR15963.1 - 1e-37 130.3 15.8 1e-37 130.3 15.8 1.5 2 0 0 2 2 2 1 MBOAT, membrane-bound O-acyltransferase family MBOAT_2 PF13813.6 ELR15963.1 - 0.00013 22.1 1.5 0.00013 22.1 1.5 3.0 4 1 0 4 4 4 1 Membrane bound O-acyl transferase family Prenylcys_lyase PF07156.14 ELR15964.1 - 2.6e-70 237.4 1.4 4.3e-43 147.8 0.2 2.1 1 1 1 2 2 2 2 Prenylcysteine lyase Amino_oxidase PF01593.24 ELR15964.1 - 2e-11 43.8 0.5 1e-10 41.5 0.3 2.1 2 1 0 2 2 2 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 ELR15964.1 - 4.6e-05 23.5 0.0 0.00014 22.0 0.0 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Erf4 PF10256.9 ELR15964.1 - 0.036 14.2 0.2 0.69 10.0 0.0 3.1 3 2 2 5 5 5 0 Golgin subfamily A member 7/ERF4 family BOFC_N PF08977.10 ELR15964.1 - 0.083 12.9 0.1 1.8 8.6 0.0 2.8 2 0 0 2 2 2 0 Bypass of Forespore C, N terminal EMP70 PF02990.16 ELR15965.1 - 1.6e-174 581.4 14.6 1.7e-141 472.5 0.0 2.2 1 1 1 2 2 2 2 Endomembrane protein 70 CopD PF05425.13 ELR15965.1 - 3.7 8.0 11.6 0.4 11.1 3.9 2.8 3 0 0 3 3 3 0 Copper resistance protein D Abhydro_lipase PF04083.16 ELR15966.1 - 1.4e-22 79.0 0.0 3.4e-22 77.8 0.0 1.6 1 0 0 1 1 1 1 Partial alpha/beta-hydrolase lipase region Abhydrolase_1 PF00561.20 ELR15966.1 - 1.4e-10 41.3 0.9 2.5e-10 40.4 0.1 1.9 2 0 0 2 2 2 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 ELR15966.1 - 1.4e-09 37.6 0.0 5.3e-08 32.4 0.0 2.3 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 ELR15966.1 - 0.00076 20.2 0.0 0.0015 19.2 0.0 1.6 1 0 0 1 1 1 1 Alpha/beta hydrolase family CDC45 PF02724.14 ELR15966.1 - 0.0013 17.1 4.3 0.0013 17.1 4.3 3.5 3 1 0 3 3 2 1 CDC45-like protein LIDHydrolase PF10230.9 ELR15966.1 - 0.0015 18.1 0.0 0.0063 16.1 0.0 1.9 2 0 0 2 2 2 1 Lipid-droplet associated hydrolase NLPC_P60 PF00877.19 ELR15966.1 - 0.0073 16.3 0.0 0.025 14.6 0.0 1.9 1 0 0 1 1 1 1 NlpC/P60 family Ser_hydrolase PF06821.13 ELR15966.1 - 0.021 14.7 0.0 0.054 13.4 0.0 1.7 1 0 0 1 1 1 0 Serine hydrolase Pro_CA PF00484.19 ELR15966.1 - 0.025 14.9 0.7 0.14 12.4 0.0 2.7 2 0 0 2 2 2 0 Carbonic anhydrase Chlorophyllase2 PF12740.7 ELR15966.1 - 0.038 12.9 0.0 0.3 9.9 0.0 2.2 2 0 0 2 2 2 0 Chlorophyllase enzyme DUF1057 PF06342.12 ELR15966.1 - 0.084 11.9 0.0 0.19 10.8 0.0 1.5 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF1057) Abhydrolase_2 PF02230.16 ELR15966.1 - 0.12 12.2 0.0 0.38 10.5 0.0 1.8 1 1 0 1 1 1 0 Phospholipase/Carboxylesterase UPF0565 PF10561.9 ELR15966.1 - 0.28 10.3 1.1 0.36 10.0 0.0 1.9 2 1 0 2 2 2 0 Uncharacterised protein family UPF0565 SR-25 PF10500.9 ELR15966.1 - 0.89 9.1 59.2 0.013 15.1 22.5 3.9 4 0 0 4 4 4 0 Nuclear RNA-splicing-associated protein Exo_endo_phos PF03372.23 ELR15967.1 - 1.5e-17 63.9 0.1 3.2e-17 62.8 0.1 1.5 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Catalase PF00199.19 ELR15968.1 - 1.2e-200 666.5 0.6 1.5e-200 666.2 0.6 1.0 1 0 0 1 1 1 1 Catalase Catalase-rel PF06628.12 ELR15968.1 - 3.4e-23 81.6 0.0 8.5e-23 80.4 0.0 1.7 1 0 0 1 1 1 1 Catalase-related immune-responsive SH3_14 PF18343.1 ELR15968.1 - 0.068 13.3 0.4 0.17 12.0 0.1 1.8 2 0 0 2 2 2 0 Dda helicase SH3 domain Dus PF01207.17 ELR15969.1 - 1.2e-44 152.7 0.0 2.2e-44 151.8 0.0 1.3 1 0 0 1 1 1 1 Dihydrouridine synthase (Dus) zf-CCCH PF00642.24 ELR15969.1 - 0.0047 16.8 13.1 0.021 14.7 2.1 2.9 3 0 0 3 3 3 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_4 PF18044.1 ELR15969.1 - 0.01 15.7 11.0 0.025 14.4 0.9 2.5 2 0 0 2 2 2 2 CCCH-type zinc finger zf_CCCH_4 PF18345.1 ELR15969.1 - 0.72 10.0 7.2 2.2 8.5 0.2 3.2 2 2 1 3 3 3 0 Zinc finger domain Pkinase PF00069.25 ELR15971.1 - 8e-14 51.6 0.0 1.8e-13 50.5 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain Acetyltransf_3 PF13302.7 ELR15972.1 - 4.3e-19 69.6 0.0 5.6e-19 69.2 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 ELR15972.1 - 6.6e-08 32.8 0.0 1e-07 32.2 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_4 PF13420.7 ELR15972.1 - 0.069 13.3 0.0 0.089 12.9 0.0 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain PD40 PF07676.12 ELR15973.1 - 4.8e-15 55.0 0.7 0.00015 21.6 0.0 4.5 4 0 0 4 4 4 3 WD40-like Beta Propeller Repeat DPPIV_N PF00930.21 ELR15973.1 - 5.9e-05 22.0 1.0 4.5 5.9 0.0 4.4 3 2 2 5 5 5 5 Dipeptidyl peptidase IV (DPP IV) N-terminal region ANAPC4_WD40 PF12894.7 ELR15973.1 - 0.0046 17.2 0.0 14 6.0 0.1 3.7 3 2 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain DUF1800 PF08811.11 ELR15975.1 - 3.8e-12 46.0 0.0 1.3e-10 40.9 0.0 2.0 1 1 1 2 2 2 2 Protein of unknown function (DUF1800) COesterase PF00135.28 ELR15976.1 - 2.2e-26 92.8 0.8 1.1e-18 67.4 0.1 2.0 1 1 1 2 2 2 2 Carboxylesterase family Pkinase_Tyr PF07714.17 ELR15977.1 - 1e-88 297.0 0.0 5.5e-45 153.7 0.0 2.1 1 1 1 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 ELR15977.1 - 3.3e-80 269.3 0.0 4.2e-39 134.5 0.0 2.1 1 1 1 2 2 2 2 Protein kinase domain PBP_like_2 PF12849.7 ELR15977.1 - 2.3e-25 89.8 0.2 6.1e-15 55.6 0.0 3.1 2 1 1 3 3 3 3 PBP superfamily domain Kinase-like PF14531.6 ELR15977.1 - 4.7e-08 32.7 0.0 0.00046 19.6 0.0 2.4 2 0 0 2 2 2 2 Kinase-like Kdo PF06293.14 ELR15977.1 - 3.3e-06 26.6 0.3 0.00035 20.0 0.0 2.4 2 1 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 ELR15977.1 - 5.5e-06 26.5 0.3 0.0026 17.7 0.0 3.0 3 0 0 3 3 3 1 Phosphotransferase enzyme family EGF_2 PF07974.13 ELR15977.1 - 7e-05 23.1 5.6 0.00014 22.1 5.6 1.5 1 0 0 1 1 1 1 EGF-like domain RIO1 PF01163.22 ELR15977.1 - 9.1e-05 22.1 1.1 0.048 13.2 0.0 3.0 2 1 0 2 2 2 1 RIO1 family FTA2 PF13095.6 ELR15977.1 - 0.00095 18.8 0.0 0.38 10.3 0.0 2.9 2 1 1 3 3 3 1 Kinetochore Sim4 complex subunit FTA2 Haspin_kinase PF12330.8 ELR15977.1 - 0.026 13.5 0.0 5.1 5.9 0.0 2.7 3 0 0 3 3 3 0 Haspin like kinase domain hEGF PF12661.7 ELR15977.1 - 0.17 12.6 5.2 0.41 11.4 5.2 1.7 1 0 0 1 1 1 0 Human growth factor-like EGF I-EGF_1 PF18372.1 ELR15977.1 - 0.17 12.0 4.7 0.33 11.1 4.7 1.4 1 0 0 1 1 1 0 Integrin beta epidermal growth factor like domain 1 Syndecan PF01034.20 ELR15977.1 - 0.31 11.0 0.7 0.78 9.7 0.7 1.6 1 0 0 1 1 1 0 Syndecan domain NAGidase PF07555.13 ELR15978.1 - 0.094 12.0 0.1 0.13 11.6 0.1 1.1 1 0 0 1 1 1 0 beta-N-acetylglucosaminidase EXS PF03124.14 ELR15980.1 - 5.2e-71 239.7 33.4 5.9e-71 239.5 33.4 1.0 1 0 0 1 1 1 1 EXS family LicD PF04991.13 ELR15982.1 - 3.7e-09 37.1 0.1 2.4e-08 34.4 0.1 1.9 2 0 0 2 2 2 1 LicD family Metallophos_C PF14008.6 ELR15985.1 - 2.5e-13 50.6 0.4 9e-13 48.9 0.1 2.0 2 1 0 2 2 2 1 Iron/zinc purple acid phosphatase-like protein C Metallophos PF00149.28 ELR15985.1 - 8.4e-08 33.0 0.4 1.5e-07 32.1 0.1 1.6 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase Pur_ac_phosph_N PF16656.5 ELR15986.1 - 3.7e-10 40.2 0.1 5.5e-10 39.7 0.1 1.3 1 0 0 1 1 1 1 Purple acid Phosphatase, N-terminal domain Metallophos PF00149.28 ELR15986.1 - 4e-10 40.5 0.1 6.4e-10 39.9 0.1 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 ELR15986.1 - 0.0022 18.2 0.0 0.0031 17.7 0.0 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain PhoD_N PF16655.5 ELR15986.1 - 0.035 14.6 0.1 0.092 13.3 0.1 1.8 1 1 0 1 1 1 0 PhoD-like phosphatase, N-terminal domain DNA_pol_A_exo1 PF01612.20 ELR15989.1 - 8e-21 74.5 0.0 1.3e-20 73.8 0.0 1.3 1 0 0 1 1 1 1 3'-5' exonuclease AAA_16 PF13191.6 ELR15989.1 - 2.2e-05 24.9 0.0 4.4e-05 23.9 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain AAA PF00004.29 ELR15989.1 - 5.7e-05 23.6 0.0 0.00012 22.6 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 ELR15989.1 - 0.00099 19.1 0.0 0.0027 17.7 0.0 1.8 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) T2SSE PF00437.20 ELR15989.1 - 0.0016 17.6 0.0 0.0024 17.0 0.0 1.2 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_19 PF13245.6 ELR15989.1 - 0.002 18.4 0.0 0.017 15.4 0.0 2.5 3 0 0 3 3 3 1 AAA domain Zeta_toxin PF06414.12 ELR15989.1 - 0.0028 17.0 0.0 0.0047 16.2 0.0 1.3 1 0 0 1 1 1 1 Zeta toxin AAA_7 PF12775.7 ELR15989.1 - 0.0038 16.8 0.0 0.0067 16.0 0.0 1.3 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_30 PF13604.6 ELR15989.1 - 0.0056 16.4 0.0 0.012 15.3 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 ELR15989.1 - 0.0091 16.3 0.0 0.027 14.7 0.0 1.9 1 1 0 1 1 1 1 AAA domain RuvB_N PF05496.12 ELR15989.1 - 0.011 15.4 0.0 0.03 14.1 0.0 1.7 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain NTPase_1 PF03266.15 ELR15989.1 - 0.02 14.8 0.0 4.8 7.1 0.0 2.4 2 0 0 2 2 2 0 NTPase AAA_24 PF13479.6 ELR15989.1 - 0.022 14.5 0.0 0.039 13.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_11 PF13086.6 ELR15989.1 - 0.03 14.1 0.1 0.16 11.7 0.0 2.0 1 1 1 2 2 2 0 AAA domain Sigma54_activat PF00158.26 ELR15989.1 - 0.031 14.0 0.0 0.31 10.7 0.0 2.2 2 0 0 2 2 2 0 Sigma-54 interaction domain Rad17 PF03215.15 ELR15989.1 - 0.035 14.0 0.0 0.068 13.1 0.0 1.4 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_18 PF13238.6 ELR15989.1 - 0.04 14.5 0.0 0.079 13.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain TrwB_AAD_bind PF10412.9 ELR15989.1 - 0.04 12.8 0.0 0.069 12.0 0.0 1.3 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain Glyco_tran_WecB PF03808.13 ELR15989.1 - 0.04 13.9 0.0 0.073 13.0 0.0 1.5 1 0 0 1 1 1 0 Glycosyl transferase WecB/TagA/CpsF family AAA_33 PF13671.6 ELR15989.1 - 0.042 14.0 0.0 0.11 12.7 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.6 ELR15989.1 - 0.044 13.4 0.1 0.17 11.4 0.0 2.0 2 1 0 2 2 2 0 AAA domain DUF815 PF05673.13 ELR15989.1 - 0.061 12.5 0.0 0.097 11.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF815) NACHT PF05729.12 ELR15989.1 - 0.086 12.7 0.0 0.15 11.9 0.0 1.4 1 0 0 1 1 1 0 NACHT domain FtsK_SpoIIIE PF01580.18 ELR15989.1 - 0.11 11.8 0.0 0.19 11.1 0.0 1.4 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_28 PF13521.6 ELR15989.1 - 0.12 12.6 0.0 0.22 11.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain TsaE PF02367.17 ELR15989.1 - 0.16 12.0 0.0 0.3 11.1 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE KAP_NTPase PF07693.14 ELR15989.1 - 0.21 10.8 0.0 0.33 10.1 0.0 1.2 1 0 0 1 1 1 0 KAP family P-loop domain Glyco_tranf_2_4 PF13704.6 ELR15990.1 - 6.2e-05 23.4 4.5 0.00059 20.3 4.5 2.2 1 1 0 1 1 1 1 Glycosyl transferase family 2 Glyco_transf_92 PF01697.27 ELR15990.1 - 0.00065 19.4 0.2 0.33 10.6 0.1 2.1 2 0 0 2 2 2 2 Glycosyltransferase family 92 3-HAO PF06052.12 ELR15991.1 - 4.1e-24 84.9 0.1 4.3e-24 84.9 0.1 1.0 1 0 0 1 1 1 1 3-hydroxyanthranilic acid dioxygenase DGF-1_C PF11040.8 ELR15992.1 - 0.26 11.3 0.8 0.43 10.6 0.2 1.6 2 0 0 2 2 2 0 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus LicD PF04991.13 ELR15993.1 - 3.9e-11 43.5 0.0 1.1e-09 38.7 0.0 2.2 2 0 0 2 2 2 2 LicD family DUF1455 PF07306.11 ELR15994.1 - 0.053 13.5 0.9 0.053 13.5 0.9 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF1455) CDP-OH_P_transf PF01066.21 ELR15996.1 - 1.4e-16 61.0 0.2 1.4e-16 61.0 0.2 2.8 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase PBP_like_2 PF12849.7 ELR15997.1 - 8.4e-34 117.5 13.5 1.1e-17 64.7 0.8 2.2 2 0 0 2 2 2 2 PBP superfamily domain Pkinase_Tyr PF07714.17 ELR15997.1 - 1.2e-23 83.8 0.1 1.8e-23 83.2 0.1 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ELR15997.1 - 5.1e-19 68.6 0.0 7.6e-19 68.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain DUF347 PF03988.12 ELR15997.1 - 0.0046 17.1 2.6 0.02 15.1 2.6 2.2 1 0 0 1 1 1 1 Repeat of Unknown Function (DUF347) EGF_2 PF07974.13 ELR15997.1 - 0.035 14.5 13.1 0.057 13.8 13.1 1.4 1 0 0 1 1 1 0 EGF-like domain AP3D1 PF06375.11 ELR15999.1 - 6.2 7.0 20.6 0.2 11.9 10.9 2.9 2 0 0 2 2 2 0 AP-3 complex subunit delta-1 Glyco_transf_34 PF05637.12 ELR16001.1 - 9.8e-14 51.7 0.2 6.2e-06 26.1 0.1 2.4 1 1 1 2 2 2 2 galactosyl transferase GMA12/MNN10 family MAP17 PF15807.5 ELR16001.1 - 0.42 10.9 5.1 0.25 11.6 3.1 1.7 2 0 0 2 2 2 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 Nucleo_P87 PF07267.11 ELR16001.1 - 0.67 8.7 4.1 0.94 8.3 4.1 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 DUF4554 PF15091.6 ELR16001.1 - 2.4 6.9 7.0 3.4 6.5 7.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4554) MCM_bind PF09739.9 ELR16001.1 - 6.5 5.1 6.7 8.7 4.7 6.7 1.1 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor Ferric_reduct PF01794.19 ELR16002.1 - 2e-20 73.2 7.9 2e-20 73.2 7.9 1.7 1 1 1 2 2 2 1 Ferric reductase like transmembrane component FAD_binding_8 PF08022.12 ELR16002.1 - 3.4e-13 49.6 0.0 6.5e-13 48.7 0.0 1.4 1 0 0 1 1 1 1 FAD-binding domain NAD_binding_6 PF08030.12 ELR16002.1 - 3.4e-09 37.0 0.0 8.2e-08 32.5 0.0 2.5 2 1 0 2 2 2 1 Ferric reductase NAD binding domain FAD_binding_6 PF00970.24 ELR16002.1 - 0.00051 20.3 0.0 0.00098 19.4 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_1 PF00175.21 ELR16002.1 - 0.009 16.6 0.0 0.017 15.8 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain DUF2484 PF10658.9 ELR16002.1 - 8.6 6.8 8.6 0.48 10.8 2.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2484) AAA_23 PF13476.6 ELR16003.1 - 1.8e-17 64.5 3.7 1.8e-17 64.5 3.7 3.4 1 1 1 2 2 2 1 AAA domain SMC_N PF02463.19 ELR16003.1 - 1.2e-11 44.4 0.1 1.3e-10 41.1 0.1 2.3 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain Metallophos PF00149.28 ELR16003.1 - 6.5e-07 30.0 0.0 1.3e-06 29.0 0.0 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase AAA_21 PF13304.6 ELR16003.1 - 6.1e-05 23.0 0.1 0.0025 17.7 0.0 2.3 2 0 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 ELR16003.1 - 0.00017 21.3 0.1 0.0004 20.1 0.1 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain Metallophos_2 PF12850.7 ELR16003.1 - 0.0002 21.6 0.8 0.0012 19.1 0.1 2.7 3 0 0 3 3 3 1 Calcineurin-like phosphoesterase superfamily domain MotY_N PF18393.1 ELR16003.1 - 4.6 7.4 7.6 0.54 10.4 2.9 1.9 2 0 0 2 2 2 0 MotY N-terminal domain Peptidase_S8 PF00082.22 ELR16004.1 - 2.8e-34 118.8 13.8 4.4e-34 118.1 13.3 1.3 1 1 0 1 1 1 1 Subtilase family Glyco_hydro_cc PF11790.8 ELR16005.1 - 6.8e-55 186.2 0.1 7.9e-55 186.0 0.1 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase catalytic core adh_short_C2 PF13561.6 ELR16006.1 - 3.6e-54 183.8 5.6 4.4e-45 154.1 3.8 2.3 1 1 1 2 2 2 2 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 ELR16006.1 - 9.5e-49 165.5 1.6 1.5e-48 164.8 1.6 1.3 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 ELR16006.1 - 2.6e-11 43.7 2.5 7.9e-10 38.9 2.5 2.3 1 1 0 1 1 1 1 KR domain 3HCDH_N PF02737.18 ELR16006.1 - 0.0042 17.0 1.2 0.0047 16.8 0.2 1.7 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 2-Hacid_dh_C PF02826.19 ELR16006.1 - 0.0088 15.4 0.8 0.021 14.2 0.2 1.9 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain AdoHcyase_NAD PF00670.21 ELR16006.1 - 0.033 14.3 0.2 0.059 13.4 0.2 1.3 1 0 0 1 1 1 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain Methyltransf_25 PF13649.6 ELR16006.1 - 0.08 13.7 0.1 0.17 12.6 0.1 1.6 1 0 0 1 1 1 0 Methyltransferase domain Shikimate_DH PF01488.20 ELR16006.1 - 0.082 13.0 0.5 0.26 11.3 0.3 1.9 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase UDPG_MGDP_dh_N PF03721.14 ELR16006.1 - 0.1 12.2 0.2 0.17 11.4 0.2 1.3 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain UDPGP PF01704.18 ELR16007.1 - 2.6e-169 563.3 0.0 9.8e-169 561.4 0.0 1.7 1 1 0 1 1 1 1 UTP--glucose-1-phosphate uridylyltransferase HEAT PF02985.22 ELR16008.1 - 0.00026 21.0 8.8 0.89 10.0 0.0 6.4 8 0 0 8 8 5 1 HEAT repeat CDC45 PF02724.14 ELR16008.1 - 0.0016 16.9 12.5 0.0016 16.9 12.5 1.8 2 0 0 2 2 2 1 CDC45-like protein TetR_C_6 PF13977.6 ELR16008.1 - 0.006 16.8 0.2 0.044 14.0 0.2 2.6 1 0 0 1 1 1 1 BetI-type transcriptional repressor, C-terminal HEAT_EZ PF13513.6 ELR16008.1 - 0.031 14.8 0.1 3.2 8.3 0.0 3.8 3 0 0 3 3 3 0 HEAT-like repeat RIX1 PF08167.12 ELR16008.1 - 0.067 12.9 0.0 0.21 11.3 0.0 1.9 1 0 0 1 1 1 0 rRNA processing/ribosome biogenesis CLASP_N PF12348.8 ELR16008.1 - 0.098 12.2 0.1 14 5.2 0.0 3.2 2 1 0 3 3 3 0 CLASP N terminal Connexin PF00029.19 ELR16008.1 - 0.28 10.9 2.3 0.87 9.3 2.0 2.0 2 0 0 2 2 2 0 Connexin NARP1 PF12569.8 ELR16008.1 - 0.65 8.8 11.5 1.3 7.8 11.5 1.4 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 DUF740 PF05340.12 ELR16008.1 - 0.67 8.6 9.1 2.9 6.5 8.2 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF740) Hid1 PF12722.7 ELR16008.1 - 1.1 7.3 3.4 1.8 6.6 3.4 1.2 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein TP53IP5 PF15331.6 ELR16008.1 - 1.8 8.6 5.4 4.9 7.2 5.4 1.7 1 0 0 1 1 1 0 Cellular tumour antigen p53-inducible 5 RNA_pol_Rpc4 PF05132.14 ELR16008.1 - 4.5 7.7 7.6 2.4 8.6 3.8 2.3 2 0 0 2 2 2 0 RNA polymerase III RPC4 VIT1 PF01988.19 ELR16008.1 - 6.1 6.6 5.3 4.7 7.0 2.5 2.2 2 0 0 2 2 2 0 VIT family DUF913 PF06025.12 ELR16008.1 - 8.9 5.2 6.0 29 3.5 6.0 1.8 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Titin_Z PF09042.11 ELR16009.1 - 0.058 13.4 0.6 0.84 9.6 0.1 2.4 2 0 0 2 2 2 0 Titin Z SAD_SRA PF02182.17 ELR16011.1 - 3.5e-45 153.5 0.4 3.5e-45 153.5 0.4 2.8 3 0 0 3 3 3 1 SAD/SRA domain PHD PF00628.29 ELR16011.1 - 9.8e-12 44.6 6.1 9.8e-12 44.6 6.1 3.5 3 0 0 3 3 2 1 PHD-finger zf-C3HC4_3 PF13920.6 ELR16011.1 - 1.4e-08 34.4 7.8 1.4e-08 34.4 7.8 3.7 3 1 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) DNMT1-RFD PF12047.8 ELR16011.1 - 2e-05 24.6 0.0 0.00065 19.7 0.0 2.5 2 0 0 2 2 2 1 Cytosine specific DNA methyltransferase replication foci domain Prok-RING_4 PF14447.6 ELR16011.1 - 8.8e-05 22.3 7.2 8.8e-05 22.3 7.2 3.4 4 0 0 4 4 4 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 ELR16011.1 - 0.00079 19.3 11.0 0.00079 19.3 11.0 3.4 3 1 1 4 4 3 1 zinc-RING finger domain zf-C3HC4 PF00097.25 ELR16011.1 - 0.00079 19.2 11.5 0.00079 19.2 11.5 3.3 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 ELR16011.1 - 0.0032 17.8 10.4 0.0032 17.8 10.4 3.5 3 0 0 3 3 3 2 Ring finger domain zf-C3HC4_2 PF13923.6 ELR16011.1 - 0.0036 17.1 12.0 0.0036 17.1 12.0 3.2 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 ELR16011.1 - 0.004 17.2 9.9 0.004 17.2 9.9 2.8 3 0 0 3 3 2 1 RING-type zinc-finger zf-C3HC4_4 PF15227.6 ELR16011.1 - 0.013 15.7 8.8 0.013 15.7 8.8 3.2 3 1 0 3 3 3 0 zinc finger of C3HC4-type, RING zf-RING_14 PF17978.1 ELR16011.1 - 2.6 8.5 9.6 0.092 13.2 3.0 2.0 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain Zip PF02535.22 ELR16012.1 - 9.2e-43 146.7 21.7 8.9e-41 140.2 21.7 2.0 1 1 0 1 1 1 1 ZIP Zinc transporter DUF1129 PF06570.11 ELR16012.1 - 1.2 8.6 10.9 1.3 8.5 3.1 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF1129) DUF411 PF04214.13 ELR16013.1 - 0.021 14.7 0.1 0.88 9.5 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function, DUF FUSC PF04632.12 ELR16013.1 - 0.068 11.7 2.3 0.11 11.0 2.3 1.2 1 0 0 1 1 1 0 Fusaric acid resistance protein family MORN_2 PF07661.13 ELR16014.1 - 0.0041 17.2 0.4 0.015 15.5 0.1 2.1 1 1 1 2 2 2 1 MORN repeat variant PH PF00169.29 ELR16016.1 - 2.8e-05 24.6 5.0 0.00033 21.1 5.0 2.2 1 1 0 1 1 1 1 PH domain PH_11 PF15413.6 ELR16016.1 - 0.0033 17.8 1.6 0.0033 17.8 1.6 2.6 2 1 1 3 3 3 1 Pleckstrin homology domain Apyrase PF06079.11 ELR16016.1 - 0.045 12.9 0.4 0.079 12.1 0.3 1.4 1 1 0 1 1 1 0 Apyrase DUF3446 PF11928.8 ELR16016.1 - 0.072 13.4 10.9 0.16 12.3 10.5 1.8 2 0 0 2 2 2 0 Early growth response N-terminal domain SSP160 PF06933.11 ELR16016.1 - 0.33 9.1 11.1 0.42 8.7 11.1 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 DUF515 PF04415.12 ELR16016.1 - 0.37 9.1 8.1 0.5 8.7 8.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF515) SR-25 PF10500.9 ELR16016.1 - 0.57 9.8 7.4 0.84 9.2 7.4 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Sporozoite_P67 PF05642.11 ELR16016.1 - 4.2 5.3 9.9 5.3 5.0 9.9 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen PTEN_C2 PF10409.9 ELR16017.1 - 0.00017 21.3 0.0 0.00018 21.3 0.0 1.0 1 0 0 1 1 1 1 C2 domain of PTEN tumour-suppressor protein Pkinase PF00069.25 ELR16018.1 - 1.7e-57 194.8 0.0 1e-56 192.3 0.0 2.3 2 1 1 3 3 3 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR16018.1 - 8.5e-41 139.9 0.0 1.3e-39 136.1 0.0 2.2 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 ELR16018.1 - 0.0031 16.3 0.0 0.0058 15.5 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 ELR16018.1 - 0.02 14.2 0.0 0.041 13.2 0.0 1.4 1 0 0 1 1 1 0 Kinase-like Ribosomal_L7Ae PF01248.26 ELR16019.1 - 6.8e-27 93.0 0.0 8.8e-27 92.7 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family PELOTA_1 PF15608.6 ELR16019.1 - 0.00018 21.3 0.0 0.00025 20.8 0.0 1.2 1 0 0 1 1 1 1 PELOTA RNA binding domain RNase_P_pop3 PF08228.11 ELR16019.1 - 0.0016 18.5 0.1 0.0019 18.3 0.1 1.2 1 0 0 1 1 1 1 RNase P subunit Pop3 YadA_stalk PF05662.14 ELR16019.1 - 0.026 14.9 0.5 3.7 8.0 0.1 2.3 2 0 0 2 2 2 0 Coiled stalk of trimeric autotransporter adhesin Tektin PF03148.14 ELR16020.1 - 0.065 12.0 0.0 0.77 8.5 0.0 2.0 2 0 0 2 2 2 0 Tektin family PX PF00787.24 ELR16022.1 - 2.1e-08 34.1 0.1 3.7e-08 33.4 0.1 1.3 1 0 0 1 1 1 1 PX domain TonB_2 PF13103.6 ELR16022.1 - 0.13 12.6 0.0 0.34 11.2 0.0 1.7 2 0 0 2 2 2 0 TonB C terminal PTEN_C2 PF10409.9 ELR16025.1 - 7.6e-16 58.1 0.0 1.1e-15 57.6 0.0 1.2 1 0 0 1 1 1 1 C2 domain of PTEN tumour-suppressor protein Y_phosphatase PF00102.27 ELR16025.1 - 0.00063 19.4 0.0 0.00092 18.8 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase DSPc PF00782.20 ELR16025.1 - 0.0013 18.5 0.0 0.0079 16.0 0.0 2.1 1 1 1 2 2 2 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 ELR16025.1 - 0.067 13.1 0.0 0.099 12.6 0.0 1.3 1 0 0 1 1 1 0 Tyrosine phosphatase family MitoNEET_N PF10660.9 ELR16026.1 - 0.13 12.3 0.2 0.29 11.2 0.2 1.6 1 0 0 1 1 1 0 Iron-containing outer mitochondrial membrane protein N-terminus Sh_2 PF17512.2 ELR16026.1 - 0.15 11.8 0.1 0.26 11.1 0.1 1.3 1 0 0 1 1 1 0 Metapneumovirus Small hydrophobic protein HEAT PF02985.22 ELR16026.1 - 0.56 10.6 5.9 1.2 9.6 0.1 4.3 5 0 0 5 5 5 0 HEAT repeat HEAT_2 PF13646.6 ELR16027.1 - 8.5e-05 22.9 1.5 8.5e-05 22.9 1.5 3.6 5 1 0 5 5 5 1 HEAT repeats HEAT PF02985.22 ELR16027.1 - 0.011 15.9 0.1 0.011 15.9 0.1 4.2 5 0 0 5 5 5 0 HEAT repeat SR-25 PF10500.9 ELR16027.1 - 0.042 13.5 0.2 0.042 13.5 0.2 1.9 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein Nipped-B_C PF12830.7 ELR16027.1 - 0.11 12.4 1.1 0.32 10.9 0.0 2.3 2 0 0 2 2 2 0 Sister chromatid cohesion C-terminus HEAT_EZ PF13513.6 ELR16027.1 - 0.38 11.3 3.7 1.9 9.1 0.2 3.9 2 1 1 3 3 3 0 HEAT-like repeat NOP5NT PF08156.13 ELR16028.1 - 0.044 14.2 0.0 1.1 9.7 0.0 2.2 2 0 0 2 2 2 0 NOP5NT (NUC127) domain Gln-synt_C-ter PF18318.1 ELR16028.1 - 0.09 12.6 0.0 0.17 11.7 0.0 1.5 1 1 0 1 1 1 0 Glutamine synthetase C-terminal domain Cytochrom_C1 PF02167.15 ELR16030.1 - 1.3e-36 126.4 0.0 1.8e-36 125.9 0.0 1.1 1 0 0 1 1 1 1 Cytochrome C1 family Cytochrome_CBB3 PF13442.6 ELR16030.1 - 0.0047 17.2 0.0 0.012 15.9 0.0 1.8 1 0 0 1 1 1 1 Cytochrome C oxidase, cbb3-type, subunit III Cytochrom_C PF00034.21 ELR16030.1 - 0.014 16.5 0.0 0.029 15.5 0.0 1.6 1 0 0 1 1 1 0 Cytochrome c TLD PF07534.16 ELR16031.1 - 5.9e-16 58.9 0.0 9.6e-16 58.3 0.0 1.3 1 0 0 1 1 1 1 TLD BTB_2 PF02214.22 ELR16031.1 - 7.8e-16 58.2 0.0 1.5e-15 57.3 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain Coatomer_WDAD PF04053.14 ELR16032.1 - 1.1e-151 505.8 0.0 2e-151 505.0 0.0 1.4 1 0 0 1 1 1 1 Coatomer WD associated region WD40 PF00400.32 ELR16032.1 - 5.6e-40 134.6 4.4 1.4e-07 32.1 0.1 7.7 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ELR16032.1 - 4.4e-06 26.9 0.2 6 7.2 0.0 5.3 4 1 0 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain MetallophosC PF16370.5 ELR16032.1 - 0.059 13.6 0.3 0.21 11.8 0.2 1.9 2 0 0 2 2 2 0 C terminal of Calcineurin-like phosphoesterase Nup160 PF11715.8 ELR16032.1 - 0.23 10.1 0.9 14 4.2 0.1 3.5 2 1 1 4 4 4 0 Nucleoporin Nup120/160 Amidohydro_3 PF07969.11 ELR16033.1 - 1e-102 345.0 0.4 1.3e-102 344.8 0.4 1.0 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_1 PF01979.20 ELR16033.1 - 1.2e-11 44.6 0.0 8.7e-11 41.7 0.0 2.2 3 1 0 3 3 3 1 Amidohydrolase family GMAP PF06540.11 ELR16033.1 - 0.088 12.9 0.0 0.2 11.7 0.0 1.6 1 0 0 1 1 1 0 Galanin message associated peptide (GMAP) EF-hand_1 PF00036.32 ELR16034.1 - 1.4e-22 77.4 13.1 8.1e-07 28.2 1.1 4.7 5 0 0 5 5 5 3 EF hand EF-hand_6 PF13405.6 ELR16034.1 - 3.4e-19 67.1 10.2 1.9e-05 24.2 0.1 5.0 4 1 1 5 5 5 3 EF-hand domain EF-hand_5 PF13202.6 ELR16034.1 - 7.8e-18 63.1 15.7 5.4e-07 28.8 1.5 5.0 5 0 0 5 5 5 3 EF hand EF-hand_7 PF13499.6 ELR16034.1 - 1.6e-17 63.7 7.7 3e-12 46.8 2.9 2.7 2 2 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 ELR16034.1 - 1.7e-14 53.4 7.3 0.00012 21.8 0.7 3.9 3 2 0 3 3 3 3 EF-hand domain pair SPARC_Ca_bdg PF10591.9 ELR16034.1 - 0.00047 20.5 3.0 0.48 10.8 0.4 3.3 2 2 1 3 3 3 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 ELR16034.1 - 0.0015 18.5 2.2 1.6 8.7 0.1 3.3 2 1 1 3 3 3 2 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.6 ELR16034.1 - 0.0054 17.0 0.7 0.05 13.9 0.0 2.7 3 0 0 3 3 3 1 EF-hand domain Dockerin_1 PF00404.18 ELR16034.1 - 0.01 16.0 0.0 20 5.5 0.0 3.1 3 0 0 3 3 3 0 Dockerin type I domain NADPH_Ox PF08414.10 ELR16034.1 - 0.023 15.0 0.7 0.95 9.8 0.0 2.9 1 1 1 2 2 2 0 Respiratory burst NADPH oxidase EF-hand_14 PF17959.1 ELR16034.1 - 0.19 12.1 1.4 1e+02 3.4 0.0 3.3 3 0 0 3 3 3 0 EF-hand domain EF-hand_10 PF14788.6 ELR16034.1 - 2.2 8.2 5.9 2.6 8.0 2.6 2.7 2 1 1 3 3 3 0 EF hand Peptidase_S8 PF00082.22 ELR16035.1 - 3.6e-32 111.8 13.3 5e-32 111.3 12.4 1.3 1 1 0 1 1 1 1 Subtilase family PAS_9 PF13426.7 ELR16036.1 - 0.0018 18.5 0.0 0.0036 17.5 0.0 1.5 1 0 0 1 1 1 1 PAS domain LCD1 PF09798.9 ELR16036.1 - 0.0022 16.6 0.0 0.0027 16.3 0.0 1.1 1 0 0 1 1 1 1 DNA damage checkpoint protein GIT_CC PF16559.5 ELR16036.1 - 0.01 15.7 1.3 0.021 14.7 1.3 1.5 1 0 0 1 1 1 0 GIT coiled-coil Rho guanine nucleotide exchange factor GAS PF13851.6 ELR16036.1 - 0.019 14.3 0.2 0.03 13.7 0.2 1.2 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding DUF1635 PF07795.11 ELR16036.1 - 0.027 14.4 0.7 0.027 14.4 0.7 1.8 2 0 0 2 2 1 0 Protein of unknown function (DUF1635) Mito_fiss_reg PF05308.11 ELR16036.1 - 0.027 14.6 0.1 0.027 14.6 0.1 2.8 3 0 0 3 3 3 0 Mitochondrial fission regulator PAS_3 PF08447.12 ELR16036.1 - 0.043 14.1 0.0 0.092 13.0 0.0 1.6 1 0 0 1 1 1 0 PAS fold UPF0242 PF06785.11 ELR16036.1 - 0.045 13.9 0.1 0.072 13.2 0.1 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus V_ATPase_I PF01496.19 ELR16036.1 - 0.055 11.4 0.0 0.068 11.1 0.0 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family YabA PF06156.13 ELR16036.1 - 0.057 14.1 0.4 0.16 12.6 0.4 1.8 1 1 0 1 1 1 0 Initiation control protein YabA Fmp27_WPPW PF10359.9 ELR16036.1 - 0.096 11.5 1.7 0.14 11.0 1.7 1.1 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain Trimer_CC PF08954.11 ELR16036.1 - 0.11 12.1 7.1 0.33 10.5 5.6 2.4 1 1 1 2 2 2 0 Trimerisation motif bZIP_2 PF07716.15 ELR16036.1 - 0.12 12.4 2.4 0.32 11.1 2.4 1.7 1 0 0 1 1 1 0 Basic region leucine zipper Macoilin PF09726.9 ELR16036.1 - 0.13 10.8 4.8 0.2 10.2 4.8 1.3 1 0 0 1 1 1 0 Macoilin family SKA1 PF07160.12 ELR16036.1 - 0.23 11.3 2.2 0.26 11.1 1.3 1.5 1 1 0 1 1 1 0 Spindle and kinetochore-associated protein 1 TSC22 PF01166.18 ELR16036.1 - 0.25 11.7 0.7 0.85 10.0 0.5 2.0 1 1 0 1 1 1 0 TSC-22/dip/bun family LPP PF04728.13 ELR16036.1 - 0.32 11.4 1.5 1.9 9.0 1.4 2.2 2 0 0 2 2 2 0 Lipoprotein leucine-zipper RAP1 PF07218.11 ELR16036.1 - 0.38 9.0 3.6 0.61 8.3 3.6 1.3 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) KIAA1430 PF13879.6 ELR16036.1 - 1.1 10.1 3.5 0.5 11.1 1.0 1.7 2 0 0 2 2 1 0 KIAA1430 homologue MID_MedPIWI PF18296.1 ELR16036.1 - 1.2 8.9 6.3 0.37 10.6 0.5 2.2 2 0 0 2 2 2 0 MID domain of medPIWI DUF4482 PF14818.6 ELR16036.1 - 5.6 7.8 7.0 0.23 12.3 0.4 2.0 2 0 0 2 2 1 0 Domain of unknown function (DUF4482) F-box-like PF12937.7 ELR16037.1 - 1.3e-08 34.5 1.3 1.3e-08 34.5 1.3 2.0 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 ELR16037.1 - 1.7e-07 31.0 0.6 3.1e-07 30.1 0.6 1.5 1 0 0 1 1 1 1 F-box domain F-box_4 PF15966.5 ELR16037.1 - 0.0005 19.9 0.1 0.0023 17.8 0.0 2.1 2 0 0 2 2 2 1 F-box Elongin_A PF06881.11 ELR16037.1 - 0.25 11.9 5.3 7.9 7.1 1.0 3.5 3 0 0 3 3 3 0 RNA polymerase II transcription factor SIII (Elongin) subunit A Pkinase PF00069.25 ELR16038.1 - 1.3e-19 70.7 0.0 1.3e-19 70.7 0.0 1.9 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR16038.1 - 5.2e-07 29.2 0.7 6.4e-07 28.9 0.0 1.5 2 0 0 2 2 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ELR16038.1 - 0.00023 20.6 0.0 0.00036 19.9 0.0 1.3 1 0 0 1 1 1 1 Kinase-like DUF4578 PF15147.6 ELR16038.1 - 0.049 14.5 7.4 0.076 13.9 7.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4578) DUF913 PF06025.12 ELR16038.1 - 0.17 10.9 2.4 0.23 10.4 2.4 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) DUF4820 PF16091.5 ELR16038.1 - 0.24 10.7 7.1 0.38 10.1 7.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) Sin_N PF04801.13 ELR16038.1 - 0.28 10.4 8.3 0.34 10.1 8.3 1.1 1 0 0 1 1 1 0 Sin-like protein conserved region PPL5 PF18168.1 ELR16038.1 - 0.35 10.1 4.7 0.41 9.9 4.7 1.2 1 0 0 1 1 1 0 Prim-pol family 5 Zip PF02535.22 ELR16038.1 - 0.41 9.8 2.3 0.46 9.6 2.3 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter RR_TM4-6 PF06459.12 ELR16038.1 - 0.51 10.1 13.0 0.67 9.7 13.0 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 RNA_polI_A34 PF08208.11 ELR16038.1 - 0.66 10.0 25.8 1 9.4 25.8 1.2 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 Vfa1 PF08432.10 ELR16038.1 - 1.4 9.2 16.4 1.8 8.8 16.4 1.1 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 CDC45 PF02724.14 ELR16038.1 - 3.1 6.0 14.5 4 5.6 14.5 1.0 1 0 0 1 1 1 0 CDC45-like protein U79_P34 PF03064.16 ELR16038.1 - 5.4 6.3 13.7 7.8 5.8 13.7 1.2 1 0 0 1 1 1 0 HSV U79 / HCMV P34 Peptidase_S49_N PF08496.10 ELR16038.1 - 5.6 7.0 10.0 8.7 6.4 10.0 1.4 1 0 0 1 1 1 0 Peptidase family S49 N-terminal Ferlin_C PF16165.5 ELR16038.1 - 7.2 6.5 8.7 14 5.6 8.7 1.6 1 0 0 1 1 1 0 Ferlin C-terminus Connexin PF00029.19 ELR16038.1 - 7.3 6.3 7.5 9.7 5.9 7.5 1.2 1 0 0 1 1 1 0 Connexin Paramyxo_ncap PF00973.19 ELR16038.1 - 8.4 5.2 9.3 11 4.8 9.3 1.1 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein Pkinase PF00069.25 ELR16039.1 - 4.9e-38 131.0 0.5 5.4e-37 127.6 0.5 1.9 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR16039.1 - 3.9e-17 62.4 2.4 9.1e-15 54.6 2.4 2.9 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ELR16039.1 - 0.0003 20.2 0.7 0.0045 16.3 0.0 2.3 3 0 0 3 3 3 1 Kinase-like Pkinase_fungal PF17667.1 ELR16039.1 - 0.017 13.9 4.4 0.23 10.2 0.4 2.1 1 1 1 2 2 2 0 Fungal protein kinase FTA2 PF13095.6 ELR16039.1 - 0.032 13.9 0.0 0.21 11.2 0.0 1.9 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Kdo PF06293.14 ELR16039.1 - 0.083 12.2 0.1 0.14 11.5 0.1 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family zf-HC5HC2H PF13771.6 ELR16040.1 - 0.41 10.9 5.3 1.1 9.5 5.3 1.7 1 0 0 1 1 1 0 PHD-like zinc-binding domain Bacillus_HBL PF05791.11 ELR16040.1 - 1.3 8.8 3.8 0.83 9.5 0.3 2.1 2 0 0 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) EMP24_GP25L PF01105.24 ELR16040.1 - 4.3 7.2 8.2 1.9 8.4 3.9 2.4 1 1 0 2 2 2 0 emp24/gp25L/p24 family/GOLD HALZ PF02183.18 ELR16040.1 - 4.6 7.5 19.2 0.16 12.2 1.6 4.7 4 0 0 4 4 4 0 Homeobox associated leucine zipper CRAL_TRIO PF00650.20 ELR16041.1 - 1.1e-28 100.0 0.0 1.4e-28 99.6 0.0 1.1 1 0 0 1 1 1 1 CRAL/TRIO domain AlaDh_PNT_N PF05222.15 ELR16042.1 - 2.9e-05 24.4 0.0 4.1e-05 23.9 0.0 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, N-terminal domain HA PF03457.14 ELR16043.1 - 2.8e-17 62.8 10.6 1.6e-10 41.2 0.1 2.8 3 0 0 3 3 3 2 Helicase associated domain VCX_VCY PF15231.6 ELR16043.1 - 0.019 15.7 0.5 0.019 15.7 0.5 2.4 2 0 0 2 2 2 0 Variable charge X/Y family NST1 PF13945.6 ELR16043.1 - 0.022 14.9 4.4 0.022 14.9 4.4 2.4 2 1 0 2 2 2 0 Salt tolerance down-regulator Dicty_REP PF05086.12 ELR16043.1 - 0.056 11.4 9.3 0.073 11.0 9.3 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein DUF3439 PF11921.8 ELR16043.1 - 0.16 12.0 15.8 0.09 12.7 13.6 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF3439) Ferlin_C PF16165.5 ELR16043.1 - 0.41 10.6 4.6 0.79 9.7 0.5 2.2 2 0 0 2 2 2 0 Ferlin C-terminus Shisa PF13908.6 ELR16043.1 - 0.65 10.2 7.0 1.2 9.4 7.0 1.3 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator Glypican PF01153.19 ELR16043.1 - 0.89 8.3 8.8 0.3 9.9 0.4 2.1 2 0 0 2 2 2 0 Glypican Mucin PF01456.17 ELR16043.1 - 1.2 9.1 23.5 0.69 9.9 20.3 2.0 2 0 0 2 2 2 0 Mucin-like glycoprotein AJAP1_PANP_C PF15298.6 ELR16043.1 - 3.1 8.0 11.9 0.66 10.2 8.5 1.6 2 0 0 2 2 2 0 AJAP1/PANP C-terminus BRF1 PF07741.13 ELR16043.1 - 3.3 8.1 9.8 0.34 11.3 1.9 2.8 3 0 0 3 3 3 0 Brf1-like TBP-binding domain LZ_Tnp_IS66 PF13007.7 ELR16043.1 - 3.6 8.4 9.7 5.3 7.9 0.0 3.3 3 1 0 3 3 3 0 Transposase C of IS166 homeodomain AlaDh_PNT_N PF05222.15 ELR16044.1 - 3.6e-16 59.7 0.0 4.4e-16 59.4 0.0 1.1 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, N-terminal domain Actin PF00022.19 ELR16045.1 - 5.3e-64 216.3 0.1 1e-63 215.4 0.1 1.4 1 0 0 1 1 1 1 Actin AAA_11 PF13086.6 ELR16046.1 - 0.039 13.7 2.5 0.038 13.8 2.5 1.1 1 0 0 1 1 1 0 AAA domain DUF4569 PF15133.6 ELR16046.1 - 0.17 11.6 2.5 0.21 11.3 2.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4569) DUF2229 PF09989.9 ELR16046.1 - 1.2 8.7 3.1 1.4 8.5 3.1 1.1 1 0 0 1 1 1 0 CoA enzyme activase uncharacterised domain (DUF2229) MAGE_N PF12440.8 ELR16047.1 - 3.1 8.6 10.4 5.3 7.8 10.3 1.4 1 1 0 1 1 1 0 Melanoma associated antigen family N terminal Sec23_BS PF08033.12 ELR16048.1 - 4e-05 24.3 0.0 7.5e-05 23.4 0.0 1.4 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain Rap_GAP PF02145.15 ELR16049.1 - 0.0061 16.1 0.0 0.01 15.4 0.0 1.3 1 0 0 1 1 1 1 Rap/ran-GAP CIA30 PF08547.12 ELR16050.1 - 3.1e-05 24.0 0.1 3.9e-05 23.7 0.1 1.1 1 0 0 1 1 1 1 Complex I intermediate-associated protein 30 (CIA30) DUF2740 PF10872.8 ELR16050.1 - 0.046 13.6 0.0 0.095 12.6 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2740) CIA30 PF08547.12 ELR16051.1 - 6.5e-34 117.3 0.1 8e-34 117.0 0.1 1.1 1 0 0 1 1 1 1 Complex I intermediate-associated protein 30 (CIA30) DUF2740 PF10872.8 ELR16051.1 - 0.15 12.0 0.6 0.7 9.8 0.0 2.3 3 0 0 3 3 3 0 Protein of unknown function (DUF2740) EF1_GNE PF00736.19 ELR16052.1 - 3.1e-32 110.6 1.0 5.1e-32 109.9 1.0 1.4 1 0 0 1 1 1 1 EF-1 guanine nucleotide exchange domain DUF913 PF06025.12 ELR16052.1 - 0.019 13.9 1.9 0.026 13.5 1.9 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) MinC_N PF05209.13 ELR16052.1 - 0.02 14.8 0.0 0.034 14.1 0.0 1.4 1 0 0 1 1 1 0 Septum formation inhibitor MinC, N-terminal domain PH PF00169.29 ELR16053.1 - 1e-11 45.2 0.0 2.1e-11 44.3 0.0 1.5 1 0 0 1 1 1 1 PH domain CAP_GLY PF01302.25 ELR16053.1 - 3.3e-07 30.2 0.0 7.3e-07 29.1 0.0 1.6 1 0 0 1 1 1 1 CAP-Gly domain PH_17 PF18012.1 ELR16053.1 - 0.018 14.7 0.0 0.033 13.9 0.0 1.5 1 0 0 1 1 1 0 PH domain PH_11 PF15413.6 ELR16053.1 - 0.028 14.8 0.0 0.079 13.4 0.0 1.8 1 1 0 1 1 1 0 Pleckstrin homology domain CE2_N PF17996.1 ELR16054.1 - 8e-16 58.0 0.0 1.4e-15 57.3 0.0 1.4 1 0 0 1 1 1 1 Carbohydrate esterase 2 N-terminal Lipase_GDSL_2 PF13472.6 ELR16054.1 - 0.041 14.3 0.0 0.06 13.7 0.0 1.3 1 0 0 1 1 1 0 GDSL-like Lipase/Acylhydrolase family HEAT_EZ PF13513.6 ELR16055.1 - 2.6e-15 56.5 10.6 4.3e-06 27.1 0.0 9.4 9 0 0 9 9 9 2 HEAT-like repeat HEAT PF02985.22 ELR16055.1 - 3.7e-12 45.4 23.7 0.0092 16.2 0.0 11.0 13 0 0 13 13 11 3 HEAT repeat IBN_N PF03810.19 ELR16055.1 - 1.4e-11 44.1 1.3 1.3e-10 41.0 0.8 2.9 3 0 0 3 3 3 1 Importin-beta N-terminal domain CLASP_N PF12348.8 ELR16055.1 - 2.5e-07 30.5 2.2 0.1 12.1 0.4 4.7 5 0 0 5 5 5 2 CLASP N terminal HEAT_2 PF13646.6 ELR16055.1 - 9.1e-05 22.8 21.3 0.054 13.9 0.0 7.3 6 2 4 10 10 10 3 HEAT repeats MMS19_C PF12460.8 ELR16055.1 - 0.0009 18.5 3.5 1 8.4 0.1 3.5 3 1 0 3 3 3 2 RNAPII transcription regulator C-terminal Arm PF00514.23 ELR16055.1 - 0.014 15.4 7.8 0.89 9.7 0.1 6.0 8 0 0 8 8 7 0 Armadillo/beta-catenin-like repeat HEAT_PBS PF03130.16 ELR16055.1 - 0.035 14.8 0.8 13 6.8 0.0 5.3 6 0 0 6 6 4 0 PBS lyase HEAT-like repeat RTP1_C1 PF10363.9 ELR16055.1 - 0.063 13.5 5.0 0.74 10.0 0.0 4.2 4 1 1 5 5 5 0 Required for nuclear transport of RNA pol II C-terminus 1 MMS19_N PF14500.6 ELR16055.1 - 0.087 12.4 1.2 0.38 10.3 0.1 2.6 3 0 0 3 3 3 0 Dos2-interacting transcription regulator of RNA-Pol-II RIX1 PF08167.12 ELR16055.1 - 0.093 12.5 3.6 0.87 9.3 0.2 3.8 2 2 1 4 4 4 0 rRNA processing/ribosome biogenesis Cnd3 PF12719.7 ELR16055.1 - 0.12 11.6 5.0 0.3 10.2 0.1 3.6 3 1 0 4 4 4 0 Nuclear condensing complex subunits, C-term domain DUF2939 PF11159.8 ELR16055.1 - 0.13 12.7 5.2 9 6.8 1.8 3.8 3 0 0 3 3 3 0 Protein of unknown function (DUF2939) Radical_SAM PF04055.21 ELR16056.1 - 0.0045 17.4 0.0 0.0065 16.9 0.0 1.3 1 0 0 1 1 1 1 Radical SAM superfamily Aldedh PF00171.22 ELR16057.1 - 1.9e-101 339.8 0.0 3e-101 339.2 0.0 1.2 1 1 0 1 1 1 1 Aldehyde dehydrogenase family Xpo1 PF08389.12 ELR16058.1 - 1.7e-24 86.5 2.0 1.7e-24 86.5 2.0 3.5 4 0 0 4 4 4 1 Exportin 1-like protein IBN_N PF03810.19 ELR16058.1 - 5.5e-07 29.4 0.0 6.3e-06 26.0 0.0 2.9 3 0 0 3 3 3 1 Importin-beta N-terminal domain Phage_int_SAM_1 PF02899.17 ELR16058.1 - 0.074 13.4 1.9 0.4 11.0 0.1 3.1 3 0 0 3 3 3 0 Phage integrase, N-terminal SAM-like domain DUF2608 PF11019.8 ELR16059.1 - 4.9e-05 23.0 0.0 8.6e-05 22.1 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2608) CPSF100_C PF13299.6 ELR16059.1 - 0.13 12.5 2.1 4 7.6 0.5 2.3 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal Myc_N PF01056.18 ELR16059.1 - 0.4 10.5 4.2 0.51 10.2 0.3 2.1 2 0 0 2 2 2 0 Myc amino-terminal region YqfQ PF14181.6 ELR16059.1 - 0.66 10.2 3.6 0.74 10.0 0.1 2.2 2 0 0 2 2 2 0 YqfQ-like protein RNA_pol_Rpc4 PF05132.14 ELR16059.1 - 1.4 9.3 6.4 11 6.4 1.9 2.2 2 0 0 2 2 2 0 RNA polymerase III RPC4 U1snRNP70_N PF12220.8 ELR16059.1 - 1.9 9.2 6.8 23 5.7 3.4 2.6 2 0 0 2 2 2 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal AP-5_subunit_s1 PF15001.6 ELR16059.1 - 3 7.8 5.5 14 5.6 0.0 2.6 3 0 0 3 3 3 0 AP-5 complex subunit sigma-1 DUF4834 PF16118.5 ELR16059.1 - 5.9 7.9 5.9 8.3 7.4 0.6 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) CDC45 PF02724.14 ELR16059.1 - 9.2 4.4 8.9 2.9 6.1 2.1 2.1 2 0 0 2 2 2 0 CDC45-like protein GTSE1_N PF15259.6 ELR16060.1 - 0.015 15.5 2.0 0.027 14.7 0.6 2.2 2 0 0 2 2 2 0 G-2 and S-phase expressed 1 DUF349 PF03993.12 ELR16060.1 - 0.12 12.7 0.7 0.41 11.0 0.7 1.9 1 0 0 1 1 1 0 Domain of Unknown Function (DUF349) F_actin_bund_C PF18060.1 ELR16061.1 - 2.3e-18 66.1 18.1 2.3e-18 66.1 18.1 3.7 3 1 0 3 3 3 1 F actin bundling C terminal Het-C PF07217.11 ELR16061.1 - 0.0013 17.4 1.1 0.0018 16.9 1.1 1.3 1 0 0 1 1 1 1 Heterokaryon incompatibility protein Het-C BPS1 PF05633.11 ELR16061.1 - 0.0016 17.5 0.7 0.0023 17.0 0.7 1.3 1 0 0 1 1 1 1 Protein BYPASS1-related Macoilin PF09726.9 ELR16061.1 - 0.017 13.7 14.3 0.025 13.1 14.3 1.2 1 0 0 1 1 1 0 Macoilin family Rx_N PF18052.1 ELR16061.1 - 0.025 14.8 7.0 0.025 14.8 7.0 2.7 2 1 0 3 3 3 0 Rx N-terminal domain Plasmid_RAQPRD PF09686.10 ELR16061.1 - 0.079 13.2 11.1 0.82 9.9 4.2 2.9 3 0 0 3 3 3 0 Plasmid protein of unknown function (Plasmid_RAQPRD) PXA PF02194.15 ELR16061.1 - 0.42 10.6 3.6 0.68 9.9 3.5 1.5 1 1 0 1 1 1 0 PXA domain LMBR1 PF04791.16 ELR16061.1 - 0.98 8.2 5.0 1.1 8.1 5.0 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein DUF4061 PF13270.6 ELR16061.1 - 2.8 8.3 8.4 10 6.5 8.4 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF4061) COMMD1_N PF17221.3 ELR16063.1 - 3.4e-34 117.2 0.3 4.4e-34 116.8 0.3 1.2 1 0 0 1 1 1 1 COMMD1 N-terminal domain COMM_domain PF07258.14 ELR16063.1 - 4.3e-06 26.8 0.0 8.8e-06 25.8 0.0 1.5 1 0 0 1 1 1 1 COMM domain ToxN_toxin PF13958.6 ELR16065.1 - 0.0038 17.5 1.1 0.0051 17.1 1.1 1.1 1 0 0 1 1 1 1 Toxin ToxN, type III toxin-antitoxin system MIP PF00230.20 ELR16066.1 - 1.9e-06 27.7 0.0 2e-06 27.7 0.0 1.0 1 0 0 1 1 1 1 Major intrinsic protein ABC_membrane PF00664.23 ELR16068.1 - 1.2e-36 126.8 29.3 1.9e-30 106.5 4.9 3.1 2 1 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 ELR16068.1 - 3.6e-16 59.9 0.0 9e-16 58.6 0.0 1.8 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 ELR16068.1 - 0.0019 17.7 0.3 0.94 8.9 0.2 2.4 1 1 1 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 ELR16068.1 - 0.0075 16.7 0.0 0.023 15.1 0.0 1.9 1 0 0 1 1 1 1 AAA ATPase domain RsgA_GTPase PF03193.16 ELR16068.1 - 0.018 15.0 0.1 0.042 13.8 0.1 1.5 1 0 0 1 1 1 0 RsgA GTPase Dynamin_N PF00350.23 ELR16068.1 - 0.02 15.0 0.1 0.02 15.0 0.1 2.1 2 0 0 2 2 2 0 Dynamin family AAA_29 PF13555.6 ELR16068.1 - 0.034 13.9 0.1 0.067 12.9 0.1 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain MMR_HSR1 PF01926.23 ELR16068.1 - 0.041 14.0 0.1 0.041 14.0 0.1 2.2 3 0 0 3 3 3 0 50S ribosome-binding GTPase NACHT PF05729.12 ELR16068.1 - 0.14 12.1 0.0 0.42 10.5 0.0 1.8 2 0 0 2 2 2 0 NACHT domain cobW PF02492.19 ELR16068.1 - 0.14 11.8 0.7 0.23 11.1 0.1 1.7 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain CDC45 PF02724.14 ELR16068.1 - 7.6 4.7 15.6 96 1.1 0.0 2.1 2 0 0 2 2 2 0 CDC45-like protein ABC_tran PF00005.27 ELR16069.1 - 7e-19 68.7 0.0 1.4e-18 67.7 0.0 1.5 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 ELR16069.1 - 0.00013 21.4 0.0 0.00015 21.3 0.0 1.1 1 0 0 1 1 1 1 RecF/RecN/SMC N terminal domain CTP_transf_like PF01467.26 ELR16070.1 - 1.3e-12 48.1 0.0 4e-12 46.5 0.0 1.8 1 1 0 1 1 1 1 Cytidylyltransferase-like CDP-OH_P_transf PF01066.21 ELR16070.1 - 3.4e-11 43.8 0.3 3.4e-11 43.8 0.3 2.8 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase zf-C3H1 PF10650.9 ELR16070.1 - 2.6 7.9 5.6 0.66 9.8 2.2 1.8 2 0 0 2 2 2 0 Putative zinc-finger domain PhoLip_ATPase_C PF16212.5 ELR16071.1 - 1.5e-72 244.4 27.2 1.5e-72 244.4 27.2 2.2 2 0 0 2 2 2 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 ELR16071.1 - 1.6e-19 69.3 2.9 1.6e-19 69.3 2.9 2.2 3 0 0 3 3 3 1 Phospholipid-translocating ATPase N-terminal Hydrolase PF00702.26 ELR16071.1 - 1.1e-10 42.2 0.1 3.3e-06 27.5 0.1 2.4 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 ELR16071.1 - 1.4e-06 28.2 0.0 4.7e-06 26.6 0.0 1.9 1 1 0 1 1 1 1 Cation transport ATPase (P-type) E1-E2_ATPase PF00122.20 ELR16071.1 - 0.00045 19.8 0.0 0.00045 19.8 0.0 3.5 4 0 0 4 4 4 1 E1-E2 ATPase Hydrolase_3 PF08282.12 ELR16071.1 - 0.0059 16.4 0.1 0.015 15.1 0.1 1.7 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 ELR16071.1 - 0.035 14.5 0.0 0.24 11.8 0.0 2.2 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase Zmiz1_N PF18028.1 ELR16071.1 - 0.084 13.2 0.0 3.7 7.9 0.0 3.1 3 0 0 3 3 3 0 Zmiz1 N-terminal tetratricopeptide repeat domain Polbeta PF18765.1 ELR16074.1 - 6.2e-06 26.2 0.0 1e-05 25.5 0.0 1.4 1 0 0 1 1 1 1 Polymerase beta, Nucleotidyltransferase NTP_transf_2 PF01909.23 ELR16074.1 - 0.0026 18.0 0.0 0.0038 17.5 0.0 1.4 1 0 0 1 1 1 1 Nucleotidyltransferase domain F-box-like PF12937.7 ELR16075.1 - 8.1e-10 38.4 3.7 2e-09 37.2 3.7 1.8 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ELR16075.1 - 3.6e-06 26.7 0.7 1e-05 25.3 0.7 1.8 1 0 0 1 1 1 1 F-box domain MMtag PF10159.9 ELR16075.1 - 0.11 12.8 0.8 0.2 12.0 0.8 1.3 1 0 0 1 1 1 0 Multiple myeloma tumor-associated Pkinase_Tyr PF07714.17 ELR16076.1 - 1.1e-95 319.9 0.0 2.7e-42 144.9 0.0 4.1 4 0 0 4 4 4 4 Protein tyrosine kinase Pkinase PF00069.25 ELR16076.1 - 6.5e-92 307.6 0.0 2.1e-46 158.4 0.0 3.1 3 0 0 3 3 3 3 Protein kinase domain PBP_like_2 PF12849.7 ELR16076.1 - 2e-22 80.2 0.1 1e-12 48.3 0.1 2.4 2 0 0 2 2 2 2 PBP superfamily domain Guanylate_cyc PF00211.20 ELR16076.1 - 3.1e-12 46.5 0.0 5.4e-12 45.7 0.0 1.4 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain APH PF01636.23 ELR16076.1 - 0.00018 21.5 2.7 0.052 13.5 0.3 3.0 2 1 1 3 3 3 2 Phosphotransferase enzyme family Kinase-like PF14531.6 ELR16076.1 - 0.00058 19.3 0.1 0.0072 15.7 0.0 2.3 2 0 0 2 2 2 1 Kinase-like Haspin_kinase PF12330.8 ELR16076.1 - 0.0034 16.4 0.0 0.56 9.1 0.0 2.4 2 1 0 2 2 2 2 Haspin like kinase domain Kdo PF06293.14 ELR16076.1 - 0.017 14.5 0.0 4.4 6.6 0.0 2.3 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family FTA2 PF13095.6 ELR16076.1 - 0.034 13.8 0.0 1.5 8.4 0.0 3.0 2 2 1 4 4 4 0 Kinetochore Sim4 complex subunit FTA2 DAP10 PF07213.11 ELR16076.1 - 0.073 13.0 0.1 0.073 13.0 0.1 2.1 2 0 0 2 2 1 0 DAP10 membrane protein EGF PF00008.27 ELR16076.1 - 0.37 11.2 5.2 0.69 10.3 5.2 1.5 1 0 0 1 1 1 0 EGF-like domain CAF1A PF12253.8 ELR16076.1 - 4.7 7.5 6.6 11 6.3 6.6 1.5 1 0 0 1 1 1 0 Chromatin assembly factor 1 subunit A DUF4692 PF15763.5 ELR16078.1 - 0.032 14.7 0.6 0.042 14.3 0.6 1.2 1 0 0 1 1 1 0 Regulator of human erythroid cell expansion (RHEX) SR-25 PF10500.9 ELR16078.1 - 1.7 8.2 6.4 2.1 7.9 6.4 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein AF-4 PF05110.13 ELR16078.1 - 4.4 5.3 6.3 5.1 5.0 6.3 1.0 1 0 0 1 1 1 0 AF-4 proto-oncoprotein DEAD PF00270.29 ELR16079.1 - 1.2e-52 178.3 0.0 2.4e-52 177.2 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ELR16079.1 - 2.9e-29 101.7 0.0 6.9e-29 100.4 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 ELR16079.1 - 0.0037 17.3 0.0 0.009 16.0 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DUF4556 PF15094.6 ELR16080.1 - 0.055 12.7 0.1 0.077 12.2 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4556) Usp PF00582.26 ELR16081.1 - 4.5e-15 56.4 1.4 2e-10 41.3 0.3 2.1 1 1 1 2 2 2 2 Universal stress protein family SoPB_HTH PF18090.1 ELR16081.1 - 0.072 13.2 0.1 0.14 12.3 0.1 1.5 1 0 0 1 1 1 0 Centromere-binding protein HTH domain Myosin_head PF00063.21 ELR16083.1 - 1.1e-41 142.9 0.0 1.5e-41 142.4 0.0 1.1 1 0 0 1 1 1 1 Myosin head (motor domain) Myosin_head PF00063.21 ELR16085.1 - 1.6e-247 823.1 0.1 1.6e-247 823.1 0.1 1.8 2 0 0 2 2 2 1 Myosin head (motor domain) DIL PF01843.19 ELR16085.1 - 9.8e-19 67.6 1.3 3.1e-18 65.9 1.3 2.0 1 0 0 1 1 1 1 DIL domain IQ PF00612.27 ELR16085.1 - 1.3e-10 40.1 26.3 0.00015 21.2 2.0 5.2 5 0 0 5 5 5 4 IQ calmodulin-binding motif Myosin_N PF02736.19 ELR16085.1 - 0.0055 16.5 0.5 0.016 15.0 0.5 1.7 1 0 0 1 1 1 1 Myosin N-terminal SH3-like domain AAA_22 PF13401.6 ELR16085.1 - 0.01 16.1 0.0 0.053 13.8 0.0 2.3 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 ELR16085.1 - 0.018 15.4 0.0 0.018 15.4 0.0 4.0 3 1 0 3 3 3 0 AAA ATPase domain TubC_N PF18563.1 ELR16085.1 - 0.051 13.6 0.6 0.17 11.9 0.6 1.9 1 0 0 1 1 1 0 TubC N-terminal docking domain FlaC_arch PF05377.11 ELR16085.1 - 0.64 10.5 7.7 1.4 9.4 5.1 3.1 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) DIOX_N PF14226.6 ELR16086.1 - 2.8e-07 31.3 0.0 4.9e-07 30.5 0.0 1.5 1 1 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal Ish1 PF10281.9 ELR16087.1 - 0.0001 22.5 0.8 0.0001 22.5 0.8 2.0 2 0 0 2 2 2 1 Putative stress-responsive nuclear envelope protein Phage_int_SAM_3 PF14659.6 ELR16087.1 - 0.051 13.8 1.7 6.7 7.1 0.5 2.7 3 0 0 3 3 3 0 Phage integrase, N-terminal SAM-like domain DDE_Tnp_1_7 PF13843.6 ELR16089.1 - 3.5e-16 59.5 0.5 4.6e-08 32.8 0.0 2.2 1 1 0 2 2 2 2 Transposase IS4 Prok-RING_1 PF14446.6 ELR16089.1 - 0.0016 18.3 4.2 0.0016 18.3 4.2 2.0 2 0 0 2 2 2 1 Prokaryotic RING finger family 1 PHD PF00628.29 ELR16089.1 - 0.008 16.1 5.0 0.008 16.1 5.0 1.9 2 0 0 2 2 2 1 PHD-finger zf-HC5HC2H_2 PF13832.6 ELR16089.1 - 0.092 12.9 4.6 0.29 11.3 3.2 2.2 2 0 0 2 2 2 0 PHD-zinc-finger like domain PHD_2 PF13831.6 ELR16089.1 - 0.72 9.5 5.6 0.54 9.9 3.0 2.1 2 0 0 2 2 2 0 PHD-finger Zn_ribbon_17 PF17120.5 ELR16089.1 - 3.3 7.4 11.6 0.14 11.8 5.1 2.1 2 0 0 2 2 2 0 Zinc-ribbon, C4HC2 type Epimerase PF01370.21 ELR16090.1 - 9.6e-24 84.2 0.0 1.2e-23 83.8 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 ELR16090.1 - 9.6e-16 57.6 0.0 1.5e-15 57.0 0.0 1.3 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.6 ELR16090.1 - 8.1e-13 48.7 0.0 2.8e-12 46.9 0.0 1.7 1 1 0 1 1 1 1 NAD(P)H-binding NAD_binding_4 PF07993.12 ELR16090.1 - 5.1e-10 39.0 0.0 4.7e-09 35.8 0.0 2.0 1 1 0 1 1 1 1 Male sterility protein GDP_Man_Dehyd PF16363.5 ELR16090.1 - 7e-10 38.8 0.0 1.1e-09 38.1 0.0 1.3 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase NmrA PF05368.13 ELR16090.1 - 2.2e-08 34.0 0.7 8.2e-08 32.1 0.7 1.8 1 1 0 1 1 1 1 NmrA-like family adh_short PF00106.25 ELR16090.1 - 0.018 14.5 0.1 0.066 12.7 0.1 1.9 2 0 0 2 2 2 0 short chain dehydrogenase Polysacc_synt_2 PF02719.15 ELR16090.1 - 0.025 13.7 0.0 0.046 12.8 0.0 1.4 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein POR_N PF01855.19 ELR16090.1 - 0.16 11.7 0.3 0.29 10.8 0.3 1.3 1 0 0 1 1 1 0 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg AA_kinase PF00696.28 ELR16090.1 - 2.9 7.4 4.8 4.5 6.8 0.3 2.6 1 1 2 3 3 3 0 Amino acid kinase family Glyco_trans_4_4 PF13579.6 ELR16090.1 - 3.5 8.0 9.2 3.3 8.1 3.8 2.3 1 1 1 2 2 2 0 Glycosyl transferase 4-like domain AAA_12 PF13087.6 ELR16091.1 - 4.3e-59 199.5 0.0 4.3e-59 199.5 0.0 3.3 5 0 0 5 5 2 1 AAA domain AAA_11 PF13086.6 ELR16091.1 - 7.7e-44 150.4 0.2 7.7e-44 150.4 0.2 8.0 2 2 1 4 4 1 1 AAA domain AAA_19 PF13245.6 ELR16091.1 - 3.4e-09 37.2 0.1 1.1e-08 35.5 0.1 1.9 1 1 0 1 1 1 1 AAA domain Viral_helicase1 PF01443.18 ELR16091.1 - 9.4e-06 25.5 3.1 0.2 11.3 0.0 4.0 4 0 0 4 4 3 3 Viral (Superfamily 1) RNA helicase PhoH PF02562.16 ELR16091.1 - 0.00046 19.7 0.0 0.0027 17.2 0.0 2.0 2 0 0 2 2 2 1 PhoH-like protein AAA_5 PF07728.14 ELR16091.1 - 0.0009 19.3 0.0 0.0055 16.7 0.0 2.2 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 ELR16091.1 - 0.0043 17.4 0.1 0.0043 17.4 0.1 3.5 3 0 0 3 3 2 1 AAA ATPase domain PIF1 PF05970.14 ELR16091.1 - 0.0045 16.2 0.0 0.023 13.9 0.0 1.9 2 0 0 2 2 2 1 PIF1-like helicase AAA_25 PF13481.6 ELR16091.1 - 0.0074 15.9 0.0 0.0074 15.9 0.0 2.3 2 0 0 2 2 1 1 AAA domain Mg_chelatase PF01078.21 ELR16091.1 - 0.014 14.8 0.1 0.12 11.8 0.0 2.2 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_22 PF13401.6 ELR16091.1 - 0.022 15.0 0.0 0.1 12.9 0.0 2.2 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 ELR16091.1 - 0.036 14.0 0.1 0.091 12.7 0.1 1.7 1 0 0 1 1 1 0 NACHT domain AAA PF00004.29 ELR16091.1 - 0.045 14.2 2.5 0.07 13.6 0.1 2.4 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) DEAD PF00270.29 ELR16091.1 - 0.12 12.1 0.0 0.23 11.2 0.0 1.4 1 0 0 1 1 1 0 DEAD/DEAH box helicase ResIII PF04851.15 ELR16091.1 - 0.39 10.7 0.0 0.39 10.7 0.0 4.0 4 0 0 4 4 2 0 Type III restriction enzyme, res subunit DUF3464 PF11947.8 ELR16092.1 - 9.2 6.0 6.7 15 5.3 6.7 1.2 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 RNase_H PF00075.24 ELR16093.1 - 0.00045 20.4 0.0 0.009 16.2 0.0 2.4 2 0 0 2 2 2 1 RNase H RVT_1 PF00078.27 ELR16093.1 - 0.013 15.0 0.0 0.023 14.2 0.0 1.3 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) Ank_2 PF12796.7 ELR16094.1 - 1.5e-33 115.2 5.9 2.7e-10 40.7 0.3 6.3 3 2 4 7 7 7 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ELR16094.1 - 3.3e-31 107.3 8.6 1.8e-05 25.2 0.0 9.4 6 4 5 11 11 11 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 ELR16094.1 - 6.8e-28 93.6 16.3 4.1e-05 23.6 0.1 11.7 12 0 0 12 12 12 5 Ankyrin repeat Ank_5 PF13857.6 ELR16094.1 - 2e-27 94.9 17.5 4.3e-07 30.1 0.6 10.2 7 4 3 10 10 10 6 Ankyrin repeats (many copies) Ank PF00023.30 ELR16094.1 - 1.1e-23 82.6 20.6 0.00017 21.8 0.3 10.9 11 0 0 11 11 11 6 Ankyrin repeat F-box-like PF12937.7 ELR16094.1 - 1.3e-07 31.4 0.0 2.6e-07 30.4 0.0 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ELR16094.1 - 0.00048 19.9 0.0 0.00086 19.1 0.0 1.4 1 0 0 1 1 1 1 F-box domain F-box_4 PF15966.5 ELR16094.1 - 0.0076 16.1 0.0 0.015 15.2 0.0 1.4 1 0 0 1 1 1 1 F-box PH PF00169.29 ELR16095.1 - 3e-15 56.6 0.4 3e-09 37.3 0.3 3.4 2 1 0 2 2 2 2 PH domain SnoaL_2 PF12680.7 ELR16095.1 - 1e-07 32.5 0.0 3.4e-07 30.8 0.0 2.0 1 0 0 1 1 1 1 SnoaL-like domain SnoaL PF07366.12 ELR16095.1 - 0.00091 19.0 0.0 0.0025 17.6 0.0 1.7 1 0 0 1 1 1 1 SnoaL-like polyketide cyclase PH_11 PF15413.6 ELR16095.1 - 0.0065 16.9 3.1 0.023 15.1 0.1 3.1 3 0 0 3 3 3 1 Pleckstrin homology domain NARP1 PF12569.8 ELR16095.1 - 2.3 7.0 9.9 0.06 12.2 1.6 2.1 2 0 0 2 2 2 0 NMDA receptor-regulated protein 1 Ank_2 PF12796.7 ELR16096.1 - 2.3e-05 24.9 0.0 2.7e-05 24.7 0.0 1.1 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 ELR16096.1 - 2.7e-05 24.2 0.1 0.097 13.3 0.0 2.2 2 0 0 2 2 2 2 Ankyrin repeat Ank_4 PF13637.6 ELR16096.1 - 5.3e-05 23.7 0.1 8.4e-05 23.1 0.1 1.3 1 1 0 1 1 1 1 Ankyrin repeats (many copies) Ank_5 PF13857.6 ELR16096.1 - 0.002 18.4 0.1 0.0039 17.5 0.1 1.5 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank PF00023.30 ELR16096.1 - 0.022 15.2 0.0 0.27 11.7 0.0 2.1 2 0 0 2 2 2 0 Ankyrin repeat Ras PF00071.22 ELR16098.1 - 2.6e-51 173.4 0.0 3e-51 173.2 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR16098.1 - 5.9e-17 62.0 0.0 8.5e-17 61.5 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR16098.1 - 1.4e-06 27.9 0.0 1.7e-06 27.6 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 ELR16098.1 - 0.0004 20.3 0.0 0.14 12.1 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase FeoB_N PF02421.18 ELR16098.1 - 0.0011 18.5 0.0 0.003 17.1 0.0 1.8 1 1 0 1 1 1 1 Ferrous iron transport protein B GTP_EFTU PF00009.27 ELR16098.1 - 0.0066 16.0 0.1 0.046 13.2 0.0 1.9 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain G-alpha PF00503.20 ELR16098.1 - 0.075 12.2 0.0 0.081 12.1 0.0 1.1 1 0 0 1 1 1 0 G-protein alpha subunit ATP_bind_1 PF03029.17 ELR16098.1 - 0.14 12.0 1.0 1.5 8.5 0.0 2.0 1 1 1 2 2 2 0 Conserved hypothetical ATP binding protein NB-ARC PF00931.22 ELR16098.1 - 0.14 11.3 0.0 0.21 10.8 0.0 1.2 1 0 0 1 1 1 0 NB-ARC domain Mito_carr PF00153.27 ELR16099.1 - 7.9e-72 237.3 5.7 2.8e-25 88.1 0.0 3.7 2 1 1 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 ELR16099.1 - 0.00015 21.0 0.1 0.047 12.8 0.0 3.1 2 1 1 3 3 3 2 Gammaproteobacterial serine protease CRT-like PF08627.10 ELR16100.1 - 3.9e-52 177.3 11.5 3.9e-52 177.3 11.5 1.5 2 1 0 2 2 2 1 CRT-like, chloroquine-resistance transporter-like SLC35F PF06027.12 ELR16100.1 - 0.00032 20.3 4.7 0.00032 20.3 4.7 1.5 2 0 0 2 2 2 1 Solute carrier family 35 2OG-FeII_Oxy_2 PF13532.6 ELR16101.1 - 2.3e-25 90.0 0.0 5.6e-25 88.7 0.0 1.6 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily PepSY_2 PF13670.6 ELR16101.1 - 0.24 11.4 1.7 0.43 10.6 0.0 2.0 2 0 0 2 2 2 0 Peptidase propeptide and YPEB domain RasGEF_N PF00618.20 ELR16102.1 - 0.018 15.3 0.0 0.021 15.1 0.0 1.2 1 0 0 1 1 1 0 RasGEF N-terminal motif EAP30 PF04157.16 ELR16103.1 - 9.1e-39 133.1 0.0 1.3e-38 132.6 0.0 1.2 1 0 0 1 1 1 1 EAP30/Vps36 family HTH_42 PF06224.12 ELR16103.1 - 0.0089 15.6 1.8 0.034 13.7 0.0 2.1 1 1 0 2 2 2 1 Winged helix DNA-binding domain AstE_AspA PF04952.14 ELR16104.1 - 2.4e-38 131.9 0.0 3.6e-38 131.3 0.0 1.2 1 0 0 1 1 1 1 Succinylglutamate desuccinylase / Aspartoacylase family HutD PF05962.11 ELR16104.1 - 3.5e-29 102.1 0.0 8.4e-29 100.8 0.0 1.6 2 0 0 2 2 2 1 HutD PilS PF08805.11 ELR16104.1 - 0.0055 16.5 0.0 0.01 15.7 0.0 1.3 1 0 0 1 1 1 1 PilS N terminal Peptidase_M99 PF17033.5 ELR16104.1 - 0.01 15.3 0.0 0.017 14.6 0.0 1.2 1 0 0 1 1 1 0 Carboxypeptidase controlling helical cell shape catalytic DUF2817 PF10994.8 ELR16104.1 - 0.14 11.5 0.1 0.24 10.7 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2817) WD40 PF00400.32 ELR16105.1 - 2.2e-15 56.8 5.3 1.1e-09 38.8 0.1 3.8 4 0 0 4 4 4 3 WD domain, G-beta repeat PQQ_3 PF13570.6 ELR16105.1 - 0.00015 22.1 0.1 0.13 12.8 0.0 2.6 2 0 0 2 2 2 2 PQQ-like domain ANAPC4_WD40 PF12894.7 ELR16105.1 - 0.00029 21.1 0.0 0.42 11.0 0.0 2.2 1 1 1 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ELR16105.1 - 0.014 14.1 0.0 0.45 9.1 0.0 2.0 1 1 1 2 2 2 0 Nucleoporin Nup120/160 Ribosomal_L7Ae PF01248.26 ELR16105.1 - 0.051 13.3 0.0 0.08 12.7 0.0 1.3 1 0 0 1 1 1 0 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family NHL PF01436.21 ELR16105.1 - 0.085 12.9 1.5 5 7.3 0.1 2.7 2 0 0 2 2 2 0 NHL repeat BppL_N PF18338.1 ELR16105.1 - 0.16 11.7 0.7 0.42 10.4 0.7 1.7 1 0 0 1 1 1 0 Lower baseplate protein N-terminal domain FERM_M PF00373.18 ELR16106.1 - 7.1e-23 81.2 0.0 2.1e-22 79.7 0.0 1.9 1 0 0 1 1 1 1 FERM central domain FERM_f0 PF16511.5 ELR16106.1 - 3.9e-21 75.1 0.3 5.6e-17 61.8 0.0 3.3 3 0 0 3 3 3 2 N-terminal or F0 domain of Talin-head FERM FERM_N PF09379.10 ELR16106.1 - 7e-14 51.5 0.0 1e-12 47.8 0.0 2.6 2 1 0 2 2 2 1 FERM N-terminal domain I_LWEQ PF01608.17 ELR16106.1 - 1.5e-13 51.3 64.0 0.00021 21.6 8.2 6.9 3 2 4 8 8 8 8 I/LWEQ domain ACBP PF00887.19 ELR16106.1 - 0.0062 16.7 0.0 0.022 15.0 0.0 2.0 1 0 0 1 1 1 1 Acyl CoA binding protein Rad60-SLD PF11976.8 ELR16106.1 - 0.012 15.5 0.0 9.7 6.1 0.0 3.0 3 0 0 3 3 3 0 Ubiquitin-2 like Rad60 SUMO-like RA PF00788.23 ELR16106.1 - 0.013 16.1 0.0 0.039 14.6 0.0 1.8 1 0 0 1 1 1 0 Ras association (RalGDS/AF-6) domain F_actin_bind PF08919.10 ELR16106.1 - 0.021 14.9 6.6 0.26 11.4 0.1 4.8 4 1 1 5 5 5 0 F-actin binding Mer2 PF09074.10 ELR16106.1 - 0.071 12.9 0.0 0.29 10.9 0.0 2.1 1 0 0 1 1 1 0 Mer2 ubiquitin PF00240.23 ELR16106.1 - 0.08 12.7 0.1 20 5.1 0.0 3.0 2 1 0 2 2 2 0 Ubiquitin family VBS PF08913.10 ELR16106.1 - 3.5 8.1 30.1 1.8 9.0 0.7 5.5 3 2 1 5 5 5 0 Vinculin Binding Site ISET-FN3_linker PF16625.5 ELR16106.1 - 3.6 8.2 5.9 0.62 10.6 0.2 2.7 3 0 0 3 3 2 0 Unstructured linking region I-set and fnIII on Brother of CDO VWA PF00092.28 ELR16107.1 - 1.2e-19 71.2 2.4 2e-19 70.5 0.6 1.9 2 0 0 2 2 2 1 von Willebrand factor type A domain VWA_3 PF13768.6 ELR16107.1 - 1.6e-15 57.4 0.0 3.8e-15 56.1 0.0 1.7 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.6 ELR16107.1 - 1.2e-14 54.9 1.1 7.1e-14 52.4 0.1 2.4 2 0 0 2 2 2 1 von Willebrand factor type A domain Porin_3 PF01459.22 ELR16108.1 - 0.00089 18.8 1.8 0.0016 17.9 0.3 2.2 3 1 0 3 3 3 1 Eukaryotic porin Ribosomal_L1 PF00687.21 ELR16109.1 - 2.2e-20 73.3 0.0 3.2e-20 72.7 0.0 1.4 1 1 0 1 1 1 1 Ribosomal protein L1p/L10e family F-box-like PF12937.7 ELR16109.1 - 2.9e-06 27.1 6.8 6.8e-06 25.9 6.8 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ELR16109.1 - 5.1e-05 23.0 4.6 0.00014 21.7 4.6 1.8 1 0 0 1 1 1 1 F-box domain F-box_5 PF18511.1 ELR16109.1 - 0.14 11.7 2.7 0.12 12.0 0.6 2.0 2 0 0 2 2 2 0 F-box Myb_DNA-bind_5 PF13873.6 ELR16110.1 - 0.14 12.2 7.2 10 6.3 1.4 3.9 4 0 0 4 4 4 0 Myb/SANT-like DNA-binding domain Bap31_Bap29_C PF18035.1 ELR16110.1 - 0.15 12.1 21.0 0.58 10.2 5.8 2.5 2 0 0 2 2 2 0 Bap31/Bap29 cytoplasmic coiled-coil domain Exonuc_VII_L PF02601.15 ELR16110.1 - 0.16 11.5 8.3 0.27 10.8 8.3 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit Atg14 PF10186.9 ELR16110.1 - 0.52 9.3 20.0 0.86 8.6 20.0 1.3 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 LPP PF04728.13 ELR16110.1 - 0.62 10.5 6.7 11 6.5 0.8 3.3 1 1 1 2 2 2 0 Lipoprotein leucine-zipper Myc-LZ PF02344.15 ELR16110.1 - 1.1 9.3 17.3 6.6 6.9 4.7 3.0 2 0 0 2 2 2 0 Myc leucine zipper domain Csm1_N PF18504.1 ELR16110.1 - 1.2 9.6 22.7 1.4 9.3 4.3 3.2 1 1 2 3 3 3 0 Csm1 N-terminal domain DUF4094 PF13334.6 ELR16110.1 - 2 8.9 16.2 2 8.9 3.8 3.1 1 1 2 3 3 3 0 Domain of unknown function (DUF4094) TMPIT PF07851.13 ELR16110.1 - 3.1 7.0 16.2 1.2 8.3 13.5 1.5 1 1 1 2 2 2 0 TMPIT-like protein Tup_N PF08581.10 ELR16110.1 - 3.2 8.1 20.6 5.3 7.4 8.3 2.4 1 1 1 2 2 2 0 Tup N-terminal LpxB PF02684.15 ELR16110.1 - 7 5.4 10.1 1.5 7.6 5.9 1.8 1 1 1 2 2 2 0 Lipid-A-disaccharide synthetase FlaC_arch PF05377.11 ELR16110.1 - 8.8 6.8 14.6 8.8 6.8 1.7 2.6 3 0 0 3 3 2 0 Flagella accessory protein C (FlaC) BLOC1_2 PF10046.9 ELR16110.1 - 8.9 6.7 14.1 1.3e+02 2.9 13.3 2.5 1 1 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF3147 PF11345.8 ELR16111.1 - 0.34 11.3 24.4 0.075 13.4 9.8 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF3147) MORN PF02493.20 ELR16112.1 - 1.9e-79 257.1 69.8 4.3e-09 35.7 0.0 14.2 14 0 0 14 14 14 14 MORN repeat B-block_TFIIIC PF04182.12 ELR16112.1 - 2e-07 31.1 1.4 11 6.2 0.0 6.1 3 3 3 6 6 6 4 B-block binding subunit of TFIIIC Peptidase_S55 PF05580.12 ELR16112.1 - 0.17 11.8 10.1 2.9 7.8 0.1 4.7 5 1 1 6 6 6 0 SpoIVB peptidase S55 F-box-like PF12937.7 ELR16113.1 - 1.5e-08 34.4 4.9 1.5e-08 34.4 4.9 2.4 2 1 0 2 2 2 1 F-box-like F-box PF00646.33 ELR16113.1 - 0.00011 21.9 0.4 0.00024 20.9 0.4 1.5 1 0 0 1 1 1 1 F-box domain KfrA_N PF11740.8 ELR16113.1 - 0.0063 17.2 0.2 0.01 16.5 0.2 1.3 1 0 0 1 1 1 1 Plasmid replication region DNA-binding N-term Ank_2 PF12796.7 ELR16114.1 - 0.00015 22.3 0.2 0.21 12.2 0.1 2.1 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 ELR16114.1 - 0.00059 20.1 0.6 7.3 7.5 0.0 3.3 3 1 0 3 3 3 2 Ankyrin repeat Ank PF00023.30 ELR16114.1 - 0.061 13.8 0.8 21 5.7 0.0 3.0 3 0 0 3 3 3 0 Ankyrin repeat F_actin_bund_C PF18060.1 ELR16115.1 - 5.7e-18 64.8 11.7 5.7e-18 64.8 11.7 2.7 1 1 0 2 2 2 1 F actin bundling C terminal STAT_alpha PF01017.20 ELR16115.1 - 0.57 10.1 9.8 0.049 13.5 3.7 1.9 1 1 1 2 2 2 0 STAT protein, all-alpha domain Erythro_esteras PF05139.14 ELR16115.1 - 5.2 6.8 16.4 10 5.8 16.4 1.5 1 1 0 1 1 1 0 Erythromycin esterase MTBP_N PF14918.6 ELR16115.1 - 7.3 6.0 9.9 0.36 10.3 1.7 2.1 1 1 1 2 2 2 0 MDM2-binding DASH_Hsk3 PF08227.11 ELR16117.1 - 0.032 14.6 1.0 0.063 13.6 1.0 1.6 1 1 0 1 1 1 0 DASH complex subunit Hsk3 like DASH_Dam1 PF08653.10 ELR16117.1 - 0.16 11.8 0.5 0.27 11.1 0.3 1.5 1 1 1 2 2 2 0 DASH complex subunit Dam1 tRNA-synt_1c PF00749.21 ELR16118.1 - 2.9e-47 161.1 0.1 6.3e-40 137.0 0.1 2.1 1 1 1 2 2 2 2 tRNA synthetases class I (E and Q), catalytic domain GST_C_2 PF13410.6 ELR16118.1 - 5.1e-05 23.2 0.1 0.00012 22.1 0.1 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 ELR16118.1 - 0.00053 20.2 0.0 0.001 19.3 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 ELR16118.1 - 0.0033 17.6 0.3 0.026 14.7 0.1 2.3 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain tRNA-synt_1e PF01406.19 ELR16118.1 - 0.01 15.2 0.0 0.015 14.6 0.0 1.3 1 0 0 1 1 1 0 tRNA synthetases class I (C) catalytic domain LETM1 PF07766.13 ELR16119.1 - 7.9e-48 163.1 2.2 7.9e-48 163.1 2.2 2.3 1 1 0 2 2 2 1 LETM1-like protein EF-hand_7 PF13499.6 ELR16119.1 - 6.6e-07 29.7 0.6 2.1e-05 24.9 0.1 2.5 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_1 PF00036.32 ELR16119.1 - 7.8e-06 25.1 0.1 0.018 14.5 0.0 2.5 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 ELR16119.1 - 0.0001 22.0 0.1 0.068 13.1 0.0 2.7 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.6 ELR16119.1 - 0.00061 19.2 0.1 0.12 12.0 0.0 2.7 2 0 0 2 2 2 1 EF hand EF-hand_8 PF13833.6 ELR16119.1 - 0.0018 18.1 0.2 0.0092 15.8 0.1 2.3 1 1 1 2 2 2 1 EF-hand domain pair Fzo_mitofusin PF04799.13 ELR16119.1 - 8 6.0 8.3 3.5 7.2 0.2 2.4 2 0 0 2 2 2 0 fzo-like conserved region CorA PF01544.18 ELR16120.1 - 1.6e-06 27.7 0.2 3.9e-06 26.4 0.0 1.7 2 0 0 2 2 2 1 CorA-like Mg2+ transporter protein Pkinase_Tyr PF07714.17 ELR16122.1 - 1.7e-94 315.9 0.0 5.5e-48 163.5 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 ELR16122.1 - 4e-87 291.9 0.0 3.5e-44 151.1 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain PBP_like_2 PF12849.7 ELR16122.1 - 1.1e-16 61.4 13.3 1.2e-12 48.1 1.4 3.3 4 0 0 4 4 4 2 PBP superfamily domain Kinase-like PF14531.6 ELR16122.1 - 1.6e-06 27.7 0.0 0.039 13.3 0.0 2.3 2 0 0 2 2 2 2 Kinase-like APH PF01636.23 ELR16122.1 - 0.00011 22.2 5.0 0.044 13.7 0.1 4.0 3 1 1 4 4 4 2 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 ELR16122.1 - 0.00018 20.4 0.0 0.0084 14.9 0.0 2.2 2 0 0 2 2 2 1 Fungal protein kinase EGF_2 PF07974.13 ELR16122.1 - 0.00065 20.0 7.9 0.0015 18.8 7.9 1.7 1 0 0 1 1 1 1 EGF-like domain Haspin_kinase PF12330.8 ELR16122.1 - 0.00079 18.5 0.1 0.057 12.4 0.0 2.2 2 0 0 2 2 2 1 Haspin like kinase domain RIO1 PF01163.22 ELR16122.1 - 0.0028 17.3 0.1 2.7 7.6 0.0 2.2 2 0 0 2 2 2 2 RIO1 family Kdo PF06293.14 ELR16122.1 - 0.015 14.7 0.0 2.2 7.6 0.0 2.3 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family FTA2 PF13095.6 ELR16122.1 - 0.17 11.4 0.0 1.4 8.5 0.0 2.4 4 0 0 4 4 4 0 Kinetochore Sim4 complex subunit FTA2 CENP-B_dimeris PF09026.10 ELR16122.1 - 0.52 10.7 2.7 1.1 9.7 2.7 1.5 1 0 0 1 1 1 0 Centromere protein B dimerisation domain EGF_Tenascin PF18720.1 ELR16122.1 - 5.7 7.1 6.7 16 5.7 6.7 1.8 1 0 0 1 1 1 0 Tenascin EGF domain GMC_oxred_N PF00732.19 ELR16123.1 - 5.2e-29 101.6 0.0 1.7e-18 67.0 0.0 2.4 2 1 0 2 2 2 2 GMC oxidoreductase GMC_oxred_C PF05199.13 ELR16123.1 - 1.2e-12 48.6 0.1 2.4e-12 47.6 0.1 1.5 1 0 0 1 1 1 1 GMC oxidoreductase FAD_binding_2 PF00890.24 ELR16123.1 - 3.4e-05 23.1 0.5 0.0068 15.5 0.3 2.3 2 0 0 2 2 2 2 FAD binding domain Pyr_redox_2 PF07992.14 ELR16123.1 - 0.0011 18.3 0.1 0.0021 17.4 0.1 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 ELR16123.1 - 0.0045 16.3 0.1 0.0069 15.7 0.1 1.2 1 0 0 1 1 1 1 FAD binding domain Lycopene_cycl PF05834.12 ELR16123.1 - 0.012 14.7 0.0 0.017 14.1 0.0 1.2 1 0 0 1 1 1 0 Lycopene cyclase protein MtrD PF04207.12 ELR16123.1 - 0.024 14.4 0.3 0.024 14.4 0.3 1.8 2 0 0 2 2 2 0 Tetrahydromethanopterin S-methyltransferase, subunit D NAD_binding_8 PF13450.6 ELR16123.1 - 0.046 14.0 4.9 0.091 13.0 2.5 2.6 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.14 ELR16123.1 - 0.076 11.7 0.7 0.13 11.0 0.7 1.3 1 0 0 1 1 1 0 HI0933-like protein DAO PF01266.24 ELR16123.1 - 0.13 11.8 2.3 0.31 10.6 1.5 2.0 2 0 0 2 2 2 0 FAD dependent oxidoreductase Pyr_redox PF00070.27 ELR16123.1 - 0.14 12.8 0.0 0.27 11.8 0.0 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 ELR16123.1 - 0.19 10.8 0.1 0.33 10.0 0.1 1.4 1 0 0 1 1 1 0 Glucose inhibited division protein A Ank_2 PF12796.7 ELR16125.1 - 1.8e-42 143.8 0.0 1e-11 45.2 0.0 4.3 2 1 2 4 4 4 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ELR16125.1 - 7.1e-36 122.1 0.4 3.6e-09 37.0 0.2 5.6 3 1 1 5 5 5 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 ELR16125.1 - 3.5e-31 103.8 0.1 0.0016 18.8 0.0 7.9 8 0 0 8 8 8 7 Ankyrin repeat Ank PF00023.30 ELR16125.1 - 9.4e-29 98.6 3.5 0.0034 17.8 0.1 8.8 9 0 0 9 9 9 6 Ankyrin repeat Ank_5 PF13857.6 ELR16125.1 - 3.2e-25 87.9 7.9 3.3e-09 36.8 0.0 7.9 4 3 4 8 8 8 7 Ankyrin repeats (many copies) RNA_pol_3_Rpc31 PF11705.8 ELR16125.1 - 0.018 15.3 4.0 0.026 14.8 4.0 1.2 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 adh_short PF00106.25 ELR16125.1 - 0.11 11.9 0.2 14 5.0 0.0 2.7 3 1 1 4 4 4 0 short chain dehydrogenase Glyoxalase_6 PF18029.1 ELR16125.1 - 0.32 11.8 9.3 16 6.3 0.0 4.8 2 2 1 4 4 4 0 Glyoxalase-like domain CENP-B_dimeris PF09026.10 ELR16125.1 - 8.2 6.9 12.8 15 6.1 12.8 1.3 1 0 0 1 1 1 0 Centromere protein B dimerisation domain NOA36 PF06524.12 ELR16125.1 - 9.8 5.4 7.4 15 4.8 7.4 1.1 1 0 0 1 1 1 0 NOA36 protein BssB_TutG PF18512.1 ELR16126.1 - 0.014 15.2 0.1 0.029 14.3 0.1 1.5 1 0 0 1 1 1 0 Benzylsuccinate synthase beta subunit DUF966 PF06136.13 ELR16126.1 - 0.51 10.0 14.7 0.62 9.7 14.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF966) Neur_chan_memb PF02932.16 ELR16126.1 - 3.3 7.7 10.4 4.3 7.3 10.4 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Macoilin PF09726.9 ELR16126.1 - 3.9 5.9 14.9 4.6 5.7 14.9 1.0 1 0 0 1 1 1 0 Macoilin family ALMT PF11744.8 ELR16126.1 - 4.3 6.0 8.7 4.6 6.0 8.7 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter WD40 PF00400.32 ELR16127.1 - 1.2e-07 32.3 0.2 0.0023 18.7 0.0 2.7 2 0 0 2 2 2 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ELR16127.1 - 0.0049 17.1 0.1 0.075 13.3 0.0 2.6 3 1 0 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ELR16127.1 - 0.062 11.9 0.0 0.09 11.4 0.0 1.2 1 0 0 1 1 1 0 Nucleoporin Nup120/160 Rap_GAP PF02145.15 ELR16128.1 - 2.7e-06 27.1 0.0 4.8e-06 26.2 0.0 1.4 1 0 0 1 1 1 1 Rap/ran-GAP adh_short PF00106.25 ELR16129.1 - 1.2e-10 41.1 0.5 2.2e-10 40.3 0.5 1.4 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ELR16129.1 - 2.8e-08 33.6 0.1 3.7e-08 33.2 0.1 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.21 ELR16129.1 - 0.003 17.0 0.1 0.0038 16.7 0.1 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NmrA PF05368.13 ELR16129.1 - 0.035 13.7 0.5 0.067 12.7 0.5 1.7 1 1 0 1 1 1 0 NmrA-like family Glucokinase PF02685.16 ELR16130.1 - 1.1e-24 87.0 0.0 6.2e-14 51.7 0.0 2.1 2 0 0 2 2 2 2 Glucokinase DUF1929 PF09118.11 ELR16131.1 - 4.1e-18 65.5 0.0 1e-17 64.2 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF1929) Kelch_6 PF13964.6 ELR16131.1 - 4.5e-12 45.8 0.2 0.093 13.1 0.0 5.8 5 1 1 6 6 6 4 Kelch motif Kelch_1 PF01344.25 ELR16131.1 - 4.4e-08 32.6 0.2 0.12 12.0 0.0 4.8 5 0 0 5 5 5 2 Kelch motif Glyoxal_oxid_N PF07250.11 ELR16131.1 - 2e-07 30.4 0.0 0.057 12.6 0.0 3.7 3 1 1 4 4 4 3 Glyoxal oxidase N-terminus Kelch_4 PF13418.6 ELR16131.1 - 4.3e-06 26.6 1.7 1.1 9.4 0.0 5.3 5 0 0 5 5 5 2 Galactose oxidase, central domain Kelch_2 PF07646.15 ELR16131.1 - 6.2e-06 26.0 0.3 2.1 8.4 0.0 5.3 6 0 0 6 6 6 2 Kelch motif Med19 PF10278.9 ELR16132.1 - 0.064 13.2 10.6 0.22 11.5 2.1 2.2 2 0 0 2 2 2 0 Mediator of RNA pol II transcription subunit 19 WDCP PF15390.6 ELR16132.1 - 0.22 9.8 6.2 0.28 9.5 6.2 1.0 1 0 0 1 1 1 0 WD repeat and coiled-coil-containing protein family Endomucin PF07010.12 ELR16132.1 - 0.24 11.3 6.6 0.31 11.0 6.6 1.1 1 0 0 1 1 1 0 Endomucin Eapp_C PF10238.9 ELR16132.1 - 3.5 7.7 6.0 16 5.5 0.3 2.2 2 0 0 2 2 2 0 E2F-associated phosphoprotein FAD_binding_4 PF01565.23 ELR16134.1 - 9.2e-24 83.8 2.1 1.6e-23 83.0 2.1 1.4 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 ELR16134.1 - 1.8e-12 47.2 0.3 3.4e-12 46.3 0.3 1.5 1 0 0 1 1 1 1 Berberine and berberine like RasGEF PF00617.19 ELR16136.1 - 8e-12 45.7 0.0 1.7e-11 44.6 0.0 1.7 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 ELR16136.1 - 3.9e-05 23.8 0.0 9.2e-05 22.6 0.0 1.6 1 0 0 1 1 1 1 RasGEF N-terminal motif RasGEF PF00617.19 ELR16138.1 - 2.8e-38 131.9 0.4 6.7e-38 130.6 0.4 1.6 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 ELR16138.1 - 3.7e-12 46.4 0.3 1.4e-11 44.6 0.1 2.0 2 0 0 2 2 2 1 RasGEF N-terminal motif NUDIX PF00293.28 ELR16139.1 - 5e-16 58.9 1.3 6.6e-16 58.6 0.0 1.7 2 0 0 2 2 2 1 NUDIX domain Pedibin PF08182.11 ELR16140.1 - 0.035 13.9 0.4 0.36 10.7 0.1 2.6 2 0 0 2 2 2 0 Pedibin/Hym-346 family APG17 PF04108.12 ELR16141.1 - 1.2e-16 60.9 2.4 2e-13 50.2 0.1 6.4 5 2 1 6 6 6 3 Autophagy protein Apg17 ATG11 PF10377.9 ELR16141.1 - 2.1e-15 56.9 0.1 2.1e-15 56.9 0.1 3.5 2 1 0 2 2 2 1 Autophagy-related protein 11 ubiquitin PF00240.23 ELR16141.1 - 2.2e-05 24.1 3.5 3.8e-05 23.4 0.0 3.2 4 0 0 4 4 4 1 Ubiquitin family OEP PF02321.18 ELR16141.1 - 0.0031 17.4 6.3 0.0031 17.4 6.3 6.6 6 1 0 7 7 7 1 Outer membrane efflux protein TBK1_ULD PF18396.1 ELR16141.1 - 0.0097 15.8 0.0 0.027 14.4 0.0 1.7 1 0 0 1 1 1 1 TANK binding kinase 1 ubiquitin-like domain HNF_C PF09354.10 ELR16141.1 - 0.058 14.5 1.2 0.2 12.7 1.2 2.0 1 0 0 1 1 1 0 HNF3 C-terminal domain Flu_NS2 PF00601.19 ELR16141.1 - 0.13 12.6 0.1 0.13 12.6 0.1 3.8 4 0 0 4 4 4 0 Influenza non-structural protein (NS2) PepSY_TM_like_2 PF16357.5 ELR16141.1 - 0.27 11.2 0.0 0.27 11.2 0.0 5.6 5 1 1 6 6 6 0 Putative PepSY_TM-like Octopine_DH PF02317.17 ELR16141.1 - 2.1 8.4 6.7 6.8 6.8 0.1 3.8 3 0 0 3 3 3 0 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain DUF3626 PF12294.8 ELR16141.1 - 4.7 6.2 9.6 0.4 9.7 0.4 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF3626) Med3 PF11593.8 ELR16142.1 - 6.7e-05 22.2 24.2 6.7e-05 22.2 24.2 6.0 4 1 2 6 6 6 1 Mediator complex subunit 3 fungal CUE PF02845.16 ELR16142.1 - 0.0027 17.4 0.0 0.0047 16.6 0.0 1.3 1 0 0 1 1 1 1 CUE domain SSP160 PF06933.11 ELR16143.1 - 0.088 11.0 7.3 0.099 10.8 7.3 1.2 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 Phage_holin_2_4 PF16082.5 ELR16144.1 - 0.044 13.5 0.4 0.094 12.5 0.4 1.5 1 0 0 1 1 1 0 Bacteriophage holin family, superfamily II-like TrbC PF04956.13 ELR16144.1 - 1.1 9.6 3.4 0.61 10.3 0.1 2.0 2 0 0 2 2 2 0 TrbC/VIRB2 family PUL PF08324.11 ELR16146.1 - 6.6e-49 166.6 4.3 8.8e-49 166.2 4.3 1.1 1 0 0 1 1 1 1 PUL domain PFU PF09070.11 ELR16146.1 - 1.8e-36 124.9 0.0 2.8e-36 124.2 0.0 1.3 1 0 0 1 1 1 1 PFU (PLAA family ubiquitin binding) WD40 PF00400.32 ELR16146.1 - 4.3e-34 116.0 12.6 7.5e-06 26.6 0.0 6.9 5 1 1 6 6 6 6 WD domain, G-beta repeat BBS2_Mid PF14783.6 ELR16146.1 - 0.00022 21.2 0.0 0.63 10.1 0.0 2.5 2 0 0 2 2 2 2 Ciliary BBSome complex subunit 2, middle region Nup160 PF11715.8 ELR16146.1 - 0.22 10.1 0.5 1.4 7.5 0.0 2.2 2 0 0 2 2 2 0 Nucleoporin Nup120/160 DEC-1_N PF04625.13 ELR16146.1 - 0.25 10.3 3.1 0.44 9.5 3.1 1.3 1 0 0 1 1 1 0 DEC-1 protein, N-terminal region Proteasome PF00227.26 ELR16147.1 - 2.4e-40 138.1 0.5 3.3e-40 137.6 0.0 1.4 2 0 0 2 2 2 1 Proteasome subunit Pr_beta_C PF12465.8 ELR16147.1 - 0.00059 19.2 0.0 0.00059 19.2 0.0 1.7 2 0 0 2 2 2 1 Proteasome beta subunits C terminal GST_C_2 PF13410.6 ELR16148.1 - 0.077 13.0 0.7 0.13 12.3 0.0 1.7 2 0 0 2 2 2 0 Glutathione S-transferase, C-terminal domain Chs7 PF12271.8 ELR16148.1 - 0.32 10.3 13.6 1.3 8.3 13.6 1.8 1 1 0 1 1 1 0 Chitin synthase export chaperone DEAD PF00270.29 ELR16150.1 - 9e-05 22.3 0.0 0.00014 21.7 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase HRDC PF00570.23 ELR16151.1 - 5.9e-12 45.4 0.1 1.3e-11 44.3 0.1 1.6 1 0 0 1 1 1 1 HRDC domain RQC PF09382.10 ELR16151.1 - 3.4e-08 33.3 0.1 5.7e-08 32.5 0.1 1.4 1 0 0 1 1 1 1 RQC domain Adeno_PVIII PF01310.18 ELR16151.1 - 0.069 12.7 0.1 0.13 11.8 0.1 1.4 1 0 0 1 1 1 0 Adenovirus hexon associated protein, protein VIII CDP-OH_P_transf PF01066.21 ELR16152.1 - 2.9e-18 66.4 0.3 2.9e-18 66.4 0.3 3.2 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase DUF2776 PF10951.8 ELR16152.1 - 0.0038 16.5 3.7 0.0038 16.5 3.7 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF2776) zf-PARP PF00645.18 ELR16153.1 - 2.5e-15 57.1 0.0 5.1e-15 56.1 0.0 1.6 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region EIF4E-T PF10477.9 ELR16153.1 - 0.037 12.9 14.0 0.047 12.5 14.0 1.1 1 0 0 1 1 1 0 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E NOA36 PF06524.12 ELR16153.1 - 0.12 11.6 4.0 0.21 10.9 4.0 1.3 1 0 0 1 1 1 0 NOA36 protein PBP1_TM PF14812.6 ELR16153.1 - 0.59 10.5 3.6 1.1 9.7 3.6 1.4 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Activator_LAG-3 PF11498.8 ELR16153.1 - 1.7 7.5 27.8 2.5 7.0 27.8 1.2 1 0 0 1 1 1 0 Transcriptional activator LAG-3 HEAT PF02985.22 ELR16154.1 - 2.6e-26 89.4 7.6 4.6e-05 23.3 0.1 9.9 10 0 0 10 10 10 6 HEAT repeat HEAT_2 PF13646.6 ELR16154.1 - 5.1e-16 58.8 3.5 2.8e-07 30.8 0.1 6.8 5 4 1 6 6 6 4 HEAT repeats Vac14_Fab1_bd PF12755.7 ELR16154.1 - 2.1e-06 28.3 0.1 1 10.0 0.0 4.5 4 2 0 4 4 4 2 Vacuolar 14 Fab1-binding region HEAT_EZ PF13513.6 ELR16154.1 - 0.00039 20.9 7.5 34 5.1 0.0 7.2 5 1 3 8 8 8 0 HEAT-like repeat MMS19_N PF14500.6 ELR16154.1 - 0.024 14.2 0.2 7 6.1 0.1 3.3 3 0 0 3 3 3 0 Dos2-interacting transcription regulator of RNA-Pol-II OSCP PF00213.18 ELR16154.1 - 0.099 12.8 0.9 5.2 7.2 0.0 3.1 3 0 0 3 3 3 0 ATP synthase delta (OSCP) subunit Kinesin PF00225.23 ELR16155.1 - 1.2e-08 34.2 0.0 0.0027 16.7 0.0 2.3 2 0 0 2 2 2 2 Kinesin motor domain DUF812 PF05667.11 ELR16155.1 - 0.0028 16.6 3.2 0.0043 16.0 3.2 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF812) Leu_zip PF15294.6 ELR16155.1 - 0.25 10.8 7.6 0.44 10.0 7.6 1.2 1 0 0 1 1 1 0 Leucine zipper FAM76 PF16046.5 ELR16155.1 - 0.43 9.9 5.8 0.86 8.9 5.8 1.4 1 0 0 1 1 1 0 FAM76 protein BAR PF03114.18 ELR16155.1 - 0.8 9.3 8.1 1.3 8.6 8.1 1.2 1 0 0 1 1 1 0 BAR domain PspA_IM30 PF04012.12 ELR16155.1 - 1.9 8.0 28.6 12 5.4 28.3 2.2 1 1 0 1 1 1 0 PspA/IM30 family ADIP PF11559.8 ELR16155.1 - 2.8 8.0 14.7 2.7 8.1 12.6 2.0 1 1 0 1 1 1 0 Afadin- and alpha -actinin-Binding Spc7 PF08317.11 ELR16155.1 - 9.4 5.0 11.3 17 4.2 11.3 1.4 1 0 0 1 1 1 0 Spc7 kinetochore protein UPF0242 PF06785.11 ELR16155.1 - 9.7 6.2 10.4 17 5.5 10.4 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus DENN PF02141.21 ELR16156.1 - 2.1e-44 151.7 1.2 3.8e-44 150.9 1.2 1.4 1 0 0 1 1 1 1 DENN (AEX-3) domain dDENN PF03455.19 ELR16156.1 - 2.2e-12 46.7 1.0 6.5e-12 45.3 1.0 1.9 1 0 0 1 1 1 1 dDENN domain uDENN PF03456.18 ELR16156.1 - 2.3e-05 25.0 0.0 0.0001 23.0 0.0 2.2 1 0 0 1 1 1 1 uDENN domain DUF883 PF05957.13 ELR16156.1 - 0.021 15.4 0.5 0.046 14.3 0.5 1.5 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF883) SPA PF08616.10 ELR16156.1 - 0.18 11.8 0.1 0.32 10.9 0.1 1.3 1 0 0 1 1 1 0 Stabilization of polarity axis Avl9 PF09794.9 ELR16156.1 - 0.33 9.6 0.5 0.84 8.3 0.2 1.6 1 1 1 2 2 2 0 Transport protein Avl9 FH2 PF02181.23 ELR16157.1 - 2e-76 257.5 0.0 2.6e-76 257.2 0.0 1.1 1 0 0 1 1 1 1 Formin Homology 2 Domain FlgM PF04316.13 ELR16157.1 - 0.017 15.5 0.2 0.08 13.3 0.2 2.1 1 0 0 1 1 1 0 Anti-sigma-28 factor, FlgM DUF2383 PF09537.10 ELR16157.1 - 0.052 13.9 0.1 0.052 13.9 0.1 2.4 3 0 0 3 3 3 0 Domain of unknown function (DUF2383) NAM-associated PF14303.6 ELR16157.1 - 0.091 13.5 1.6 0.11 13.2 0.1 1.9 2 0 0 2 2 2 0 No apical meristem-associated C-terminal domain TBCA PF02970.16 ELR16157.1 - 0.21 11.9 2.2 13 6.2 0.0 3.5 3 0 0 3 3 3 0 Tubulin binding cofactor A Ank_2 PF12796.7 ELR16158.1 - 1.4e-59 198.7 2.8 7.8e-18 64.9 0.7 5.2 1 1 3 5 5 5 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ELR16158.1 - 5.8e-50 167.1 4.7 3.4e-11 43.4 0.2 8.4 4 1 4 8 8 8 8 Ankyrin repeats (many copies) Ank PF00023.30 ELR16158.1 - 1.7e-45 151.5 14.3 8.6e-06 26.0 0.3 10.0 10 0 0 10 10 10 8 Ankyrin repeat Ank_3 PF13606.6 ELR16158.1 - 1e-41 136.1 7.3 0.00015 22.0 0.1 11.0 11 0 0 11 11 11 9 Ankyrin repeat Ank_5 PF13857.6 ELR16158.1 - 8.8e-41 137.5 13.1 1.7e-09 37.8 0.1 8.0 5 3 4 9 9 9 8 Ankyrin repeats (many copies) PH PF00169.29 ELR16158.1 - 2.6e-08 34.3 0.0 4.7e-08 33.5 0.0 1.5 1 0 0 1 1 1 1 PH domain IQ_SEC7_PH PF16453.5 ELR16158.1 - 0.0091 16.0 0.1 0.015 15.3 0.1 1.3 1 0 0 1 1 1 1 PH domain CAF20 PF17052.5 ELR16158.1 - 0.32 11.1 2.9 0.69 10.1 2.9 1.5 1 0 0 1 1 1 0 Cap associated factor SH3_2 PF07653.17 ELR16159.1 - 0.17 11.6 0.0 0.31 10.7 0.0 1.4 1 0 0 1 1 1 0 Variant SH3 domain PIP5K PF01504.18 ELR16160.1 - 6.9e-68 228.8 0.0 1.5e-67 227.7 0.0 1.6 1 0 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase DZR PF12773.7 ELR16160.1 - 0.0013 18.7 2.6 0.0027 17.7 2.6 1.4 1 0 0 1 1 1 1 Double zinc ribbon zinc_ribbon_2 PF13240.6 ELR16160.1 - 0.027 14.2 8.9 0.048 13.4 8.9 1.4 1 0 0 1 1 1 0 zinc-ribbon domain Nudix_N_2 PF14803.6 ELR16160.1 - 6.7 6.7 8.3 0.76 9.7 0.2 2.6 2 0 0 2 2 2 0 Nudix N-terminal Synaptobrevin PF00957.21 ELR16161.1 - 7.2e-30 102.6 3.4 1.1e-29 102.0 3.4 1.3 1 0 0 1 1 1 1 Synaptobrevin Longin PF13774.6 ELR16161.1 - 3.4e-19 68.7 0.0 5.8e-19 67.9 0.0 1.4 1 0 0 1 1 1 1 Regulated-SNARE-like domain CCSMST1 PF15013.6 ELR16161.1 - 0.021 15.0 0.6 0.2 11.9 0.3 2.3 2 0 0 2 2 2 0 CCSMST1 family Tex_N PF09371.10 ELR16161.1 - 0.031 13.9 0.1 0.042 13.5 0.1 1.2 1 0 0 1 1 1 0 Tex-like protein N-terminal domain DUF2096 PF09869.9 ELR16161.1 - 0.062 13.4 1.0 0.7 10.0 0.3 2.3 1 1 1 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2096) Cir_Bir_Yir PF06022.11 ELR16161.1 - 4.2 6.8 6.5 0.32 10.4 1.2 1.7 1 1 1 2 2 2 0 Plasmodium variant antigen protein Cir/Yir/Bir RNA_polI_A34 PF08208.11 ELR16162.1 - 0.011 15.8 15.0 0.029 14.5 15.0 1.7 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 DUF1419 PF07215.11 ELR16162.1 - 0.08 13.0 0.2 0.34 11.0 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1419) CLU PF13236.6 ELR16163.1 - 6.1e-50 170.1 0.0 1.5e-49 168.8 0.0 1.5 2 0 0 2 2 2 1 Clustered mitochondria eIF3_p135 PF12807.7 ELR16163.1 - 2.1e-07 31.2 0.0 3.6e-07 30.4 0.0 1.3 1 0 0 1 1 1 1 Translation initiation factor eIF3 subunit 135 YhhN PF07947.14 ELR16164.1 - 0.0077 15.9 4.9 0.22 11.1 0.6 2.0 1 1 1 2 2 2 2 YhhN family NIF PF03031.18 ELR16164.1 - 0.056 13.2 0.1 0.072 12.9 0.1 1.1 1 0 0 1 1 1 0 NLI interacting factor-like phosphatase ODV-E18 PF10717.9 ELR16164.1 - 0.13 12.2 0.0 0.15 12.0 0.0 1.2 1 0 0 1 1 1 0 Occlusion-derived virus envelope protein ODV-E18 RVT_2 PF07727.14 ELR16165.1 - 2.3e-30 106.1 5.7 1.8e-26 93.3 0.6 2.7 1 1 1 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) DPPIV_N PF00930.21 ELR16167.1 - 2.9e-48 164.4 5.2 1.8e-26 92.8 0.0 3.9 3 1 1 4 4 4 3 Dipeptidyl peptidase IV (DPP IV) N-terminal region Peptidase_S9 PF00326.21 ELR16167.1 - 1.2e-43 149.1 0.0 1.9e-43 148.4 0.0 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family DLH PF01738.18 ELR16167.1 - 0.0018 17.8 0.1 0.016 14.7 0.1 2.1 1 1 0 1 1 1 1 Dienelactone hydrolase family Peptidase_S15 PF02129.18 ELR16167.1 - 0.0055 16.3 0.1 0.16 11.5 0.1 2.8 1 1 1 2 2 2 1 X-Pro dipeptidyl-peptidase (S15 family) Esterase PF00756.20 ELR16167.1 - 0.0064 16.2 0.0 0.013 15.2 0.0 1.4 1 0 0 1 1 1 1 Putative esterase Esterase_phd PF10503.9 ELR16167.1 - 0.025 14.1 0.0 0.088 12.3 0.0 1.8 2 0 0 2 2 2 0 Esterase PHB depolymerase Abhydrolase_6 PF12697.7 ELR16167.1 - 0.044 14.4 0.6 0.18 12.4 0.0 2.2 1 1 0 2 2 2 0 Alpha/beta hydrolase family AXE1 PF05448.12 ELR16167.1 - 0.14 10.8 0.0 0.24 10.0 0.0 1.3 1 0 0 1 1 1 0 Acetyl xylan esterase (AXE1) DHR-2 PF06920.13 ELR16168.1 - 4.2e-166 553.7 0.0 5.2e-166 553.4 0.0 1.1 1 0 0 1 1 1 1 Dock homology region 2 DOCK-C2 PF14429.6 ELR16168.1 - 1.9e-43 148.6 0.0 1.4e-41 142.5 0.0 2.3 2 0 0 2 2 2 1 C2 domain in Dock180 and Zizimin proteins DUF3398 PF11878.8 ELR16168.1 - 1.5e-11 44.7 0.0 5e-11 43.0 0.0 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF3398) AP3D1 PF06375.11 ELR16168.1 - 0.54 10.5 4.4 1.4 9.1 4.4 1.7 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 BolA PF01722.18 ELR16169.1 - 1.9e-11 44.1 0.0 3.5e-11 43.2 0.0 1.4 1 1 0 1 1 1 1 BolA-like protein IMUP PF15761.5 ELR16169.1 - 0.13 13.0 1.9 0.19 12.4 1.9 1.2 1 0 0 1 1 1 0 Immortalisation up-regulated protein BTB_2 PF02214.22 ELR16170.1 - 3.5e-05 24.1 0.0 8.5e-05 22.8 0.0 1.7 2 0 0 2 2 2 1 BTB/POZ domain BTB_3 PF16017.5 ELR16170.1 - 0.00094 19.3 0.0 0.002 18.2 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain Macoilin PF09726.9 ELR16170.1 - 0.0029 16.3 2.2 0.0037 15.9 2.2 1.0 1 0 0 1 1 1 1 Macoilin family SR-25 PF10500.9 ELR16170.1 - 0.028 14.0 9.1 0.054 13.1 9.1 1.5 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein SPRY PF00622.28 ELR16171.1 - 1.8e-15 57.1 0.0 2.6e-15 56.6 0.0 1.2 1 0 0 1 1 1 1 SPRY domain Neuralized PF07177.12 ELR16171.1 - 0.0014 18.7 0.0 0.0019 18.2 0.0 1.3 1 0 0 1 1 1 1 Neuralized BTB_2 PF02214.22 ELR16171.1 - 0.0027 18.0 0.0 0.0054 17.0 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain eIF-6 PF01912.18 ELR16172.1 - 6e-82 273.8 1.2 8.2e-82 273.4 0.8 1.4 2 0 0 2 2 2 1 eIF-6 family WD40 PF00400.32 ELR16174.1 - 6.8e-29 99.5 10.5 6.1e-06 26.9 0.1 6.6 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ELR16174.1 - 6e-08 32.9 0.0 0.32 11.3 0.0 4.4 4 0 0 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Cytochrom_D1 PF02239.16 ELR16174.1 - 5.2e-05 21.9 0.4 1.1 7.7 0.0 3.2 2 1 0 3 3 3 3 Cytochrome D1 heme domain Frtz PF11768.8 ELR16174.1 - 0.03 12.7 0.0 2.7 6.2 0.0 2.4 3 0 0 3 3 3 0 WD repeat-containing and planar cell polarity effector protein Fritz WD40_like PF17005.5 ELR16174.1 - 0.11 11.9 0.0 0.54 9.5 0.1 2.0 2 0 0 2 2 2 0 WD40-like domain Fasciclin PF02469.22 ELR16175.1 - 3.7e-31 108.0 7.3 2.5e-09 37.4 0.0 4.9 4 1 0 4 4 4 4 Fasciclin domain p450 PF00067.22 ELR16177.1 - 1.6e-70 238.2 0.0 1.9e-70 237.9 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Ras PF00071.22 ELR16178.1 - 4.3e-38 130.5 0.1 5.1e-38 130.2 0.1 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR16178.1 - 5.5e-07 29.8 0.0 9.1e-07 29.1 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase RsgA_GTPase PF03193.16 ELR16178.1 - 0.00045 20.2 0.0 0.00064 19.7 0.0 1.2 1 0 0 1 1 1 1 RsgA GTPase GTP_EFTU PF00009.27 ELR16178.1 - 0.0005 19.7 0.1 0.0008 19.0 0.1 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain Arf PF00025.21 ELR16178.1 - 0.00061 19.3 0.1 0.00078 18.9 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family FeoB_N PF02421.18 ELR16178.1 - 0.0024 17.4 0.0 0.0051 16.3 0.0 1.5 1 1 0 1 1 1 1 Ferrous iron transport protein B TPP_enzyme_M PF00205.22 ELR16178.1 - 0.11 12.2 0.0 0.18 11.6 0.0 1.5 1 0 0 1 1 1 0 Thiamine pyrophosphate enzyme, central domain PPR_2 PF13041.6 ELR16179.1 - 2e-60 200.8 2.1 6.3e-11 42.3 0.0 10.2 4 3 6 10 10 10 10 PPR repeat family PPR_3 PF13812.6 ELR16179.1 - 1.9e-57 191.2 0.0 1.1e-10 41.4 0.0 8.5 5 3 3 8 8 8 7 Pentatricopeptide repeat domain PPR PF01535.20 ELR16179.1 - 7.8e-50 163.7 3.3 2.9e-05 24.0 0.0 10.3 10 1 0 10 10 10 7 PPR repeat PPR_1 PF12854.7 ELR16179.1 - 1.2e-42 143.3 0.0 6.8e-06 25.7 0.0 8.8 8 0 0 8 8 8 7 PPR repeat PPR_long PF17177.4 ELR16179.1 - 1.2e-31 109.8 5.9 4e-11 42.7 0.1 4.4 3 1 2 5 5 5 5 Pentacotripeptide-repeat region of PRORP TPR_14 PF13428.6 ELR16179.1 - 7.3e-07 29.5 8.9 0.044 14.6 0.7 6.8 6 2 2 8 8 5 1 Tetratricopeptide repeat TPR_19 PF14559.6 ELR16179.1 - 3.5e-06 27.4 4.7 0.0059 17.1 0.3 4.2 3 2 1 4 4 4 1 Tetratricopeptide repeat Wzy_C_2 PF11846.8 ELR16179.1 - 0.021 14.7 5.9 12 5.8 0.5 4.4 5 0 0 5 5 5 0 Virulence factor membrane-bound polymerase, C-terminal TPR_12 PF13424.6 ELR16179.1 - 0.022 15.1 1.4 0.11 12.8 1.0 2.5 2 1 0 2 2 2 0 Tetratricopeptide repeat TPR_10 PF13374.6 ELR16179.1 - 0.023 14.5 1.0 0.53 10.2 0.1 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat CD34_antigen PF06365.12 ELR16179.1 - 0.026 14.1 0.0 0.054 13.1 0.0 1.5 1 0 0 1 1 1 0 CD34/Podocalyxin family ANAPC3 PF12895.7 ELR16179.1 - 0.026 14.7 1.1 1.2 9.4 0.2 3.5 3 0 0 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 COX7B PF05392.11 ELR16179.1 - 0.034 13.8 0.2 0.097 12.4 0.2 1.7 1 0 0 1 1 1 0 Cytochrome C oxidase chain VIIB RPN7 PF10602.9 ELR16179.1 - 0.049 13.3 0.1 7.1 6.3 0.0 2.5 2 0 0 2 2 2 0 26S proteasome subunit RPN7 EloA-BP1 PF15870.5 ELR16179.1 - 0.13 12.5 0.2 1.2 9.4 0.0 2.3 2 0 0 2 2 2 0 ElonginA binding-protein 1 TPR_2 PF07719.17 ELR16179.1 - 0.4 10.9 4.8 5.3 7.4 0.2 4.1 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_17 PF13431.6 ELR16179.1 - 0.7 10.4 2.1 3 8.4 0.1 3.2 5 0 0 5 5 3 0 Tetratricopeptide repeat eRF1_2 PF03464.15 ELR16180.1 - 2.8e-41 140.9 0.0 4.6e-41 140.3 0.0 1.3 1 0 0 1 1 1 1 eRF1 domain 2 eRF1_3 PF03465.15 ELR16180.1 - 1.2e-36 125.7 0.1 2.2e-36 124.8 0.1 1.5 1 0 0 1 1 1 1 eRF1 domain 3 eRF1_1 PF03463.15 ELR16180.1 - 1.1e-18 67.5 0.0 1.7e-18 66.9 0.0 1.3 1 0 0 1 1 1 1 eRF1 domain 1 baeRF_family10 PF18854.1 ELR16180.1 - 9.8e-08 32.3 0.0 1.8e-07 31.5 0.0 1.4 1 0 0 1 1 1 1 Bacterial archaeo-eukaryotic release factor family 10 acVLRF1 PF18859.1 ELR16180.1 - 1.9e-07 31.4 0.0 3.4e-07 30.6 0.0 1.5 1 0 0 1 1 1 1 Actinobacteria/chloroflexi VLRF1 release factor Ribosomal_L7Ae PF01248.26 ELR16180.1 - 0.065 13.0 0.0 0.13 12.0 0.0 1.5 1 0 0 1 1 1 0 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family Pkinase_Tyr PF07714.17 ELR16181.1 - 2.9e-41 141.5 0.0 4.1e-27 95.1 0.0 2.4 1 1 1 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 ELR16181.1 - 4.2e-41 141.1 0.0 9.4e-38 130.1 0.0 2.3 1 1 0 1 1 1 1 Protein kinase domain SH2 PF00017.24 ELR16181.1 - 3.2e-10 40.0 0.0 5.5e-10 39.2 0.0 1.4 1 0 0 1 1 1 1 SH2 domain Cbl_N2 PF02761.14 ELR16181.1 - 0.02 15.6 0.2 0.052 14.3 0.2 1.7 1 0 0 1 1 1 0 CBL proto-oncogene N-terminus, EF hand-like domain IBP39 PF11422.8 ELR16181.1 - 0.043 13.6 0.0 0.078 12.7 0.0 1.3 1 0 0 1 1 1 0 Initiator binding protein 39 kDa SH2_2 PF14633.6 ELR16181.1 - 0.061 12.7 0.0 0.12 11.7 0.0 1.5 1 0 0 1 1 1 0 SH2 domain Pkinase_fungal PF17667.1 ELR16181.1 - 0.061 12.1 0.0 0.083 11.7 0.0 1.3 1 0 0 1 1 1 0 Fungal protein kinase UFD1 PF03152.14 ELR16182.1 - 3.4e-36 124.3 0.0 3.3e-35 121.1 0.0 2.0 1 1 0 1 1 1 1 Ubiquitin fusion degradation protein UFD1 ubiquitin PF00240.23 ELR16182.1 - 2.5e-07 30.3 0.0 5.7e-07 29.2 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin family Ubiquitin_2 PF14560.6 ELR16182.1 - 0.0041 17.6 0.0 0.011 16.1 0.0 1.7 1 1 0 1 1 1 1 Ubiquitin-like domain zf_UBZ PF18439.1 ELR16182.1 - 0.0055 16.3 3.4 0.27 10.9 0.1 3.2 3 0 0 3 3 3 1 Ubiquitin-Binding Zinc Finger CDC48_2 PF02933.17 ELR16182.1 - 0.16 11.8 0.0 0.47 10.3 0.0 1.8 1 0 0 1 1 1 0 Cell division protein 48 (CDC48), domain 2 RR_TM4-6 PF06459.12 ELR16182.1 - 0.31 10.8 4.2 0.47 10.2 4.2 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 UPF0242 PF06785.11 ELR16182.1 - 0.57 10.3 7.9 0.83 9.7 7.9 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus HalOD2 PF18547.1 ELR16182.1 - 1.3 9.0 4.2 0.44 10.5 0.2 2.4 3 0 0 3 3 3 0 Halobacterial output domain 2 Sina PF03145.16 ELR16182.1 - 1.5 8.7 8.3 2.6 8.0 7.4 1.8 1 1 1 2 2 2 0 Seven in absentia protein family U79_P34 PF03064.16 ELR16182.1 - 3.3 7.0 9.5 6.3 6.1 9.5 1.4 1 0 0 1 1 1 0 HSV U79 / HCMV P34 Presenilin PF01080.17 ELR16182.1 - 5.1 5.7 5.2 7.3 5.2 5.2 1.1 1 0 0 1 1 1 0 Presenilin zf-TRAF PF02176.18 ELR16182.1 - 5.2 7.8 11.3 1.2 9.9 6.2 2.3 1 1 1 2 2 2 0 TRAF-type zinc finger DUF5401 PF17380.2 ELR16182.1 - 9.8 4.1 27.9 14 3.6 27.9 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5401) S4 PF01479.25 ELR16183.1 - 8.7e-11 41.4 0.0 1.6e-10 40.5 0.0 1.5 1 0 0 1 1 1 1 S4 domain Ribosomal_S4 PF00163.19 ELR16183.1 - 6.4e-08 33.4 1.3 1.1e-07 32.7 1.3 1.4 1 0 0 1 1 1 1 Ribosomal protein S4/S9 N-terminal domain Methyltransf_21 PF05050.12 ELR16184.1 - 1.9e-13 50.8 0.0 3e-13 50.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase FkbM domain RhoGEF PF00621.20 ELR16185.1 - 7.8e-36 124.0 0.6 7.8e-36 124.0 0.6 1.9 2 0 0 2 2 2 1 RhoGEF domain PH PF00169.29 ELR16185.1 - 0.034 14.7 0.0 0.085 13.4 0.0 1.7 1 0 0 1 1 1 0 PH domain RCC1 PF00415.18 ELR16186.1 - 7.6e-37 125.7 14.7 6e-15 55.6 1.0 5.1 4 1 0 4 4 4 4 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 ELR16186.1 - 1e-27 95.3 22.8 4.3e-09 35.9 1.2 4.4 4 0 0 4 4 4 4 Regulator of chromosome condensation (RCC1) repeat CMAS PF02353.20 ELR16186.1 - 0.21 10.9 0.0 0.3 10.3 0.0 1.2 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase PAP_assoc PF03828.19 ELR16187.1 - 9.9e-08 32.1 0.3 1.5e-06 28.3 0.3 2.4 1 1 0 1 1 1 1 Cid1 family poly A polymerase Sporozoite_P67 PF05642.11 ELR16187.1 - 0.03 12.4 11.3 0.0051 15.0 7.6 1.5 2 0 0 2 2 2 0 Sporozoite P67 surface antigen Sec8_exocyst PF04048.14 ELR16188.1 - 9.7e-10 38.5 0.2 1.9e-08 34.3 0.2 2.7 1 1 0 1 1 1 1 Sec8 exocyst complex component specific domain M_domain PF12938.7 ELR16188.1 - 0.083 12.7 11.0 0.19 11.5 0.9 2.9 3 0 0 3 3 3 0 M domain of GW182 Uds1 PF15456.6 ELR16188.1 - 2.4 8.3 13.8 1.3 9.1 0.3 4.9 5 0 0 5 5 5 0 Up-regulated During Septation Nup84_Nup100 PF04121.13 ELR16189.1 - 1.2e-150 503.1 2.6 1.3e-150 502.9 2.6 1.0 1 0 0 1 1 1 1 Nuclear pore protein 84 / 107 Nic96 PF04097.14 ELR16189.1 - 0.00019 20.0 0.2 0.00042 18.9 0.2 1.5 1 0 0 1 1 1 1 Nup93/Nic96 Nucleopor_Nup85 PF07575.13 ELR16189.1 - 0.037 12.6 0.3 0.065 11.8 0.3 1.3 1 0 0 1 1 1 0 Nup85 Nucleoporin PSD2 PF07624.11 ELR16189.1 - 0.13 12.1 0.6 5 7.0 0.2 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1585) RasGEF PF00617.19 ELR16190.1 - 5.7e-49 166.7 0.0 1.1e-48 165.8 0.0 1.5 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 ELR16190.1 - 2.4e-09 37.4 0.3 2.4e-09 37.4 0.3 2.0 2 0 0 2 2 2 1 RasGEF N-terminal motif DUF5427 PF10310.9 ELR16190.1 - 1.9 7.3 18.9 3.5 6.5 18.9 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5427) E1-E2_ATPase PF00122.20 ELR16191.1 - 4.8e-47 159.8 3.0 4.8e-47 159.8 3.0 2.1 2 1 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.26 ELR16191.1 - 3.6e-39 135.2 2.2 4e-39 135.1 0.3 2.0 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase HMA PF00403.26 ELR16191.1 - 9.7e-39 131.6 11.3 1.7e-15 57.2 0.5 4.5 4 0 0 4 4 4 3 Heavy-metal-associated domain Hydrolase_6 PF13344.6 ELR16191.1 - 0.01 15.9 0.2 0.1 12.8 0.0 2.7 2 1 0 2 2 2 0 Haloacid dehalogenase-like hydrolase HAD PF12710.7 ELR16191.1 - 0.03 14.7 1.4 0.046 14.1 0.0 2.0 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase CENP-B_dimeris PF09026.10 ELR16191.1 - 0.11 12.9 8.3 1.8 9.0 5.3 2.8 2 0 0 2 2 2 0 Centromere protein B dimerisation domain SNAD4 PF18750.1 ELR16191.1 - 0.13 12.3 0.1 0.56 10.3 0.0 2.0 2 0 0 2 2 2 0 Secreted Novel AID/APOBEC-like Deaminase 4 HAD_2 PF13419.6 ELR16191.1 - 0.16 12.0 0.0 0.31 11.1 0.0 1.4 1 0 0 1 1 1 0 Haloacid dehalogenase-like hydrolase FAM176 PF14851.6 ELR16191.1 - 1.1 8.9 4.4 1.6 8.3 0.4 2.8 3 0 0 3 3 3 0 FAM176 family DUF2273 PF10031.9 ELR16191.1 - 3.5 7.7 4.8 1.3 9.1 1.3 2.2 2 0 0 2 2 2 0 Small integral membrane protein (DUF2273) RNA_pol_inhib PF16857.5 ELR16191.1 - 3.6 7.5 5.4 1.3 8.9 1.3 2.4 2 1 0 2 2 2 0 RNA polymerase inhibitor Exo_endo_phos PF03372.23 ELR16192.1 - 2.6e-10 40.2 0.4 5.6e-10 39.1 0.4 1.6 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family RhoGAP PF00620.27 ELR16193.1 - 4.5e-24 85.0 0.0 6.7e-24 84.4 0.0 1.3 1 0 0 1 1 1 1 RhoGAP domain DSPc PF00782.20 ELR16194.1 - 1.1e-23 83.5 0.0 1.2e-23 83.3 0.0 1.0 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Init_tRNA_PT PF04179.12 ELR16194.1 - 2.4e-05 24.6 0.2 0.00018 21.8 0.2 2.0 1 1 0 1 1 1 1 Rit1 DUSP-like domain Y_phosphatase PF00102.27 ELR16194.1 - 0.023 14.3 0.0 0.024 14.2 0.0 1.1 1 0 0 1 1 1 0 Protein-tyrosine phosphatase CDKN3 PF05706.12 ELR16194.1 - 0.055 13.1 0.0 0.074 12.7 0.0 1.2 1 0 0 1 1 1 0 Cyclin-dependent kinase inhibitor 3 (CDKN3) Y_phosphatase2 PF03162.13 ELR16194.1 - 0.086 12.4 0.0 0.28 10.7 0.0 1.7 1 1 0 1 1 1 0 Tyrosine phosphatase family UCH PF00443.29 ELR16195.1 - 1.2e-38 133.0 0.1 5.2e-37 127.7 0.1 2.4 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 ELR16195.1 - 0.00078 19.1 1.3 0.26 10.8 1.3 3.0 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase DUF2218 PF09981.9 ELR16195.1 - 0.018 15.4 0.0 0.051 14.0 0.0 1.7 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2218) eIF-3c_N PF05470.12 ELR16195.1 - 0.16 10.2 0.1 0.24 9.7 0.1 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 8 N-terminus CSN8_PSD8_EIF3K PF10075.9 ELR16196.1 - 2.7e-23 82.6 0.0 4.5e-23 81.8 0.0 1.3 1 0 0 1 1 1 1 CSN8/PSMD8/EIF3K family Tmemb_14 PF03647.13 ELR16197.1 - 2.4e-20 73.0 11.8 2.8e-20 72.8 11.8 1.1 1 0 0 1 1 1 1 Transmembrane proteins 14C DUF4149 PF13664.6 ELR16197.1 - 0.38 11.1 4.7 0.56 10.6 4.7 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4149) DUF4231 PF14015.6 ELR16197.1 - 1.8 9.0 4.8 0.51 10.8 1.3 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF4231) SH3_9 PF14604.6 ELR16198.1 - 4.7e-07 29.6 0.0 9e-07 28.7 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 ELR16198.1 - 4.5e-06 26.2 0.0 8.9e-06 25.2 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SR-25 PF10500.9 ELR16198.1 - 3.1e-05 23.7 37.4 0.00049 19.8 36.2 2.1 1 1 1 2 2 2 2 Nuclear RNA-splicing-associated protein SH3_2 PF07653.17 ELR16198.1 - 5.5e-05 22.8 0.0 0.00011 21.8 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain LMBR1 PF04791.16 ELR16198.1 - 0.29 10.0 7.3 0.6 9.0 6.7 1.6 2 0 0 2 2 2 0 LMBR1-like membrane protein DUF3915 PF13054.6 ELR16198.1 - 0.6 10.1 4.6 10 6.2 0.3 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3915) Med19 PF10278.9 ELR16198.1 - 1.1 9.1 21.0 0.87 9.5 11.1 2.2 2 0 0 2 2 2 0 Mediator of RNA pol II transcription subunit 19 Ferlin_C PF16165.5 ELR16198.1 - 1.2 9.1 10.9 0.18 11.7 3.9 2.2 2 0 0 2 2 2 0 Ferlin C-terminus MAP65_ASE1 PF03999.12 ELR16198.1 - 1.3 7.7 20.1 1.7 7.3 20.1 1.2 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) DUF4407 PF14362.6 ELR16198.1 - 1.4 8.2 8.7 2.1 7.6 8.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) SRP-alpha_N PF04086.13 ELR16198.1 - 1.7 8.5 19.6 2.3 8.1 19.6 1.3 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal Ndc1_Nup PF09531.10 ELR16198.1 - 3.8 6.1 13.1 5.2 5.6 13.1 1.3 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup SOBP PF15279.6 ELR16198.1 - 4.1 7.9 14.4 5.3 7.6 14.4 1.3 1 0 0 1 1 1 0 Sine oculis-binding protein AAA_23 PF13476.6 ELR16198.1 - 4.2 7.8 13.5 3.4 8.1 1.9 2.3 2 0 0 2 2 2 0 AAA domain DUF572 PF04502.13 ELR16198.1 - 5 6.7 19.4 5.8 6.4 19.4 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF572) DUF2956 PF11169.8 ELR16198.1 - 5 7.4 15.7 5 7.4 1.5 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2956) Golgin_A5 PF09787.9 ELR16198.1 - 5.2 6.4 14.6 0.58 9.6 5.3 2.2 2 0 0 2 2 2 0 Golgin subfamily A member 5 Hamartin PF04388.12 ELR16198.1 - 9.3 4.8 14.3 9.7 4.7 14.3 1.1 1 0 0 1 1 1 0 Hamartin protein Pkinase PF00069.25 ELR16199.1 - 2e-14 53.6 0.0 1e-08 34.9 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain F-box-like PF12937.7 ELR16199.1 - 1.6e-07 31.1 0.7 3.4e-07 30.1 0.7 1.6 1 0 0 1 1 1 1 F-box-like Pkinase_Tyr PF07714.17 ELR16199.1 - 0.00028 20.3 0.0 0.012 14.9 0.0 2.1 2 0 0 2 2 2 1 Protein tyrosine kinase F-box PF00646.33 ELR16199.1 - 0.0033 17.2 0.3 0.0074 16.1 0.3 1.6 1 0 0 1 1 1 1 F-box domain VGPC1_C PF16799.5 ELR16200.1 - 0.35 10.9 1.7 0.64 10.0 0.2 2.1 2 0 0 2 2 2 0 C-terminal membrane-localisation domain of ion-channel, VCN1 ZapB PF06005.12 ELR16200.1 - 9.1 6.8 10.3 1.4e+02 3.0 10.4 2.3 1 1 0 1 1 1 0 Cell division protein ZapB EGF_2 PF07974.13 ELR16201.1 - 1.3 9.5 71.6 1.5 9.2 13.7 4.5 4 0 0 4 4 4 0 EGF-like domain Arf PF00025.21 ELR16202.1 - 9.4e-38 129.4 0.0 1.2e-37 129.0 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family G-alpha PF00503.20 ELR16202.1 - 1.9e-09 37.1 0.0 8.4e-06 25.2 0.0 2.3 1 1 1 2 2 2 2 G-protein alpha subunit Ras PF00071.22 ELR16202.1 - 3.1e-09 36.6 0.0 4.9e-09 36.0 0.0 1.3 1 1 0 1 1 1 1 Ras family Roc PF08477.13 ELR16202.1 - 5.6e-09 36.2 0.0 2.2e-08 34.3 0.0 1.8 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 ELR16202.1 - 6.1e-09 35.6 0.0 8e-09 35.2 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 ELR16202.1 - 1e-05 25.0 0.0 1.9e-05 24.1 0.0 1.3 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 ELR16202.1 - 4.5e-05 23.5 0.0 6.5e-05 23.0 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase ATP_bind_1 PF03029.17 ELR16202.1 - 0.0019 18.1 0.0 0.02 14.7 0.0 1.9 1 1 1 2 2 2 1 Conserved hypothetical ATP binding protein AAA_22 PF13401.6 ELR16202.1 - 0.011 16.0 0.0 0.014 15.6 0.0 1.2 1 0 0 1 1 1 0 AAA domain GTP_EFTU PF00009.27 ELR16202.1 - 0.017 14.6 0.0 5.1 6.6 0.0 2.1 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain cobW PF02492.19 ELR16202.1 - 0.21 11.2 0.2 14 5.2 0.0 2.1 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain PseudoU_synth_2 PF00849.22 ELR16203.1 - 2.9e-14 53.5 0.1 5.4e-14 52.6 0.1 1.5 1 0 0 1 1 1 1 RNA pseudouridylate synthase S4 PF01479.25 ELR16203.1 - 5e-13 48.5 0.2 2.2e-12 46.5 0.0 2.3 2 0 0 2 2 2 1 S4 domain His_Phos_2 PF00328.22 ELR16204.1 - 1.2e-24 87.4 0.0 6e-15 55.5 0.1 2.2 2 0 0 2 2 2 2 Histidine phosphatase superfamily (branch 2) Rep_fac-A_C PF08646.10 ELR16205.1 - 5.3e-41 139.8 0.2 1.5e-40 138.3 0.1 1.8 2 0 0 2 2 2 1 Replication factor-A C terminal domain Rep-A_N PF04057.12 ELR16205.1 - 4.3e-26 90.9 0.0 1e-25 89.7 0.0 1.6 1 0 0 1 1 1 1 Replication factor-A protein 1, N-terminal domain REPA_OB_2 PF16900.5 ELR16205.1 - 2.3e-25 88.3 0.2 1.7e-22 79.2 0.2 2.5 2 0 0 2 2 2 2 Replication protein A OB domain tRNA_anti-codon PF01336.25 ELR16205.1 - 3.8e-10 39.6 0.1 2.8e-07 30.4 0.0 3.3 3 0 0 3 3 3 1 OB-fold nucleic acid binding domain CDC24_OB3 PF17244.2 ELR16205.1 - 0.00084 19.1 0.3 0.66 9.6 0.0 2.7 3 0 0 3 3 3 2 Cell division control protein 24, OB domain 3 DUF3565 PF12088.8 ELR16205.1 - 0.17 11.9 0.9 0.46 10.5 0.9 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3565) RPN7 PF10602.9 ELR16206.1 - 2e-56 190.5 0.1 3.8e-56 189.5 0.1 1.5 1 0 0 1 1 1 1 26S proteasome subunit RPN7 PCI PF01399.27 ELR16206.1 - 7e-19 68.3 2.1 6e-18 65.3 0.3 2.7 2 1 0 2 2 2 1 PCI domain TPR_2 PF07719.17 ELR16206.1 - 0.0062 16.6 3.4 0.15 12.2 0.0 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_MalT PF17874.1 ELR16206.1 - 0.082 12.3 0.0 0.14 11.5 0.0 1.2 1 0 0 1 1 1 0 MalT-like TPR region TPR_1 PF00515.28 ELR16206.1 - 0.14 12.0 0.1 0.71 9.8 0.0 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat Adaptin_N PF01602.20 ELR16207.1 - 0.0031 16.1 3.2 0.0087 14.7 0.6 2.9 1 1 1 2 2 2 1 Adaptin N terminal region HEAT PF02985.22 ELR16207.1 - 0.0042 17.2 9.8 15 6.2 0.1 6.5 4 1 1 5 5 5 2 HEAT repeat DnaG_DnaB_bind PF08278.11 ELR16207.1 - 0.013 16.1 0.0 0.013 16.1 0.0 4.3 3 2 2 5 5 5 0 DNA primase DnaG DnaB-binding HEAT_2 PF13646.6 ELR16207.1 - 7.7 7.0 26.2 2.7 8.4 0.4 5.9 3 2 4 7 7 7 0 HEAT repeats DUF3284 PF11687.8 ELR16209.1 - 0.029 14.2 1.0 0.044 13.7 1.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3284) PhoLip_ATPase_C PF16212.5 ELR16210.1 - 3.1e-75 253.2 23.7 3.9e-75 252.8 23.7 1.1 1 0 0 1 1 1 1 Phospholipid-translocating P-type ATPase C-terminal Hydrolase PF00702.26 ELR16210.1 - 2.5e-08 34.4 0.1 0.00076 19.8 0.0 2.4 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 ELR16210.1 - 0.012 15.3 0.0 0.031 14.0 0.0 1.6 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 ELR16210.1 - 0.037 14.1 0.0 0.29 11.2 0.0 2.2 2 0 0 2 2 2 0 Cation transport ATPase (P-type) CDT1 PF08839.11 ELR16210.1 - 0.21 11.8 1.2 1.1 9.6 0.3 2.2 2 0 0 2 2 2 0 DNA replication factor CDT1 like Ank_2 PF12796.7 ELR16211.1 - 1.1e-40 138.0 3.6 2.9e-17 63.0 0.1 3.0 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank PF00023.30 ELR16211.1 - 2.3e-27 94.2 1.8 1.7e-05 25.1 0.1 5.2 4 1 1 5 5 5 5 Ankyrin repeat Ank_3 PF13606.6 ELR16211.1 - 1.9e-26 89.2 1.8 2.4e-05 24.4 0.0 5.3 4 1 1 5 5 5 5 Ankyrin repeat Ank_4 PF13637.6 ELR16211.1 - 3.3e-26 91.3 3.8 3.6e-11 43.4 0.0 4.3 1 1 3 4 4 4 4 Ankyrin repeats (many copies) Ank_5 PF13857.6 ELR16211.1 - 3.5e-17 62.2 5.0 8.9e-06 25.9 0.1 4.9 1 1 4 5 5 5 5 Ankyrin repeats (many copies) Pkinase_Tyr PF07714.17 ELR16212.1 - 9.4e-51 172.6 0.0 1.4e-50 172.0 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ELR16212.1 - 7.8e-45 153.3 0.0 2.5e-29 102.5 0.0 2.6 3 0 0 3 3 3 2 Protein kinase domain COR PF16095.5 ELR16212.1 - 9.7e-22 77.7 0.0 3.6e-13 49.8 0.0 2.5 1 1 1 2 2 2 2 C-terminal of Roc, COR, domain Roc PF08477.13 ELR16212.1 - 1.6e-20 73.5 0.0 9.5e-20 71.0 0.0 2.4 3 0 0 3 3 2 1 Ras of Complex, Roc, domain of DAPkinase LRR_8 PF13855.6 ELR16212.1 - 6.3e-10 38.7 0.2 1.6e-09 37.4 0.2 1.7 1 0 0 1 1 1 1 Leucine rich repeat Ras PF00071.22 ELR16212.1 - 1.5e-08 34.4 0.0 8.2e-08 32.0 0.0 2.2 2 1 0 2 2 2 1 Ras family WD40 PF00400.32 ELR16212.1 - 2.7e-07 31.2 5.3 0.0092 16.8 0.4 4.5 3 0 0 3 3 3 2 WD domain, G-beta repeat Arf PF00025.21 ELR16212.1 - 1e-06 28.3 0.2 0.00044 19.7 0.0 2.8 2 1 0 2 2 2 1 ADP-ribosylation factor family LRR_4 PF12799.7 ELR16212.1 - 0.0008 19.8 0.4 0.5 10.9 0.0 2.7 2 0 0 2 2 2 1 Leucine Rich repeats (2 copies) ANAPC4_WD40 PF12894.7 ELR16212.1 - 0.0028 17.9 0.7 3.4 8.0 0.1 2.9 2 0 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain Pkinase_fungal PF17667.1 ELR16212.1 - 0.074 11.8 0.2 0.16 10.7 0.0 1.6 2 0 0 2 2 2 0 Fungal protein kinase LRR_1 PF00560.33 ELR16212.1 - 0.12 13.0 0.7 16 6.5 0.1 3.1 2 0 0 2 2 2 0 Leucine Rich Repeat AAA_15 PF13175.6 ELR16212.1 - 0.12 12.0 1.1 0.18 11.5 0.0 1.9 2 0 0 2 2 2 0 AAA ATPase domain ISPD_C PF18706.1 ELR16212.1 - 0.18 11.4 0.0 0.54 9.9 0.0 1.7 1 0 0 1 1 1 0 D-ribitol-5-phosphate cytidylyltransferase C-terminal domain LRR_6 PF13516.6 ELR16212.1 - 0.38 10.9 1.0 4.1 7.7 0.4 2.6 2 0 0 2 2 2 0 Leucine Rich repeat FAM199X PF15814.5 ELR16212.1 - 1.4 7.9 6.8 1.8 7.6 0.9 2.4 2 0 0 2 2 2 0 Protein family FAM199X Ras PF00071.22 ELR16213.1 - 4.8e-24 84.8 0.0 6.1e-24 84.4 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR16213.1 - 1.9e-08 34.5 0.0 2.6e-08 34.1 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase IstB_IS21 PF01695.17 ELR16213.1 - 0.049 13.4 0.0 0.077 12.7 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_16 PF13191.6 ELR16213.1 - 0.055 13.8 0.1 0.069 13.5 0.1 1.5 1 1 0 1 1 1 0 AAA ATPase domain AAA_22 PF13401.6 ELR16213.1 - 0.092 13.0 0.0 0.095 13.0 0.0 1.4 1 1 0 1 1 1 0 AAA domain MMR_HSR1 PF01926.23 ELR16213.1 - 0.11 12.6 0.0 0.14 12.2 0.0 1.6 1 1 0 1 1 1 0 50S ribosome-binding GTPase DUF2075 PF09848.9 ELR16213.1 - 0.15 11.2 0.0 0.15 11.2 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_33 PF13671.6 ELR16213.1 - 0.18 11.9 1.6 0.5 10.5 1.6 1.9 1 1 0 1 1 1 0 AAA domain PBP1_TM PF14812.6 ELR16214.1 - 4.4e-05 23.8 8.3 4.4e-05 23.8 8.3 4.8 3 2 1 4 4 4 1 Transmembrane domain of transglycosylase PBP1 at N-terminal Herpes_gE PF02480.16 ELR16214.1 - 0.38 9.4 1.6 0.57 8.9 1.6 1.3 1 0 0 1 1 1 0 Alphaherpesvirus glycoprotein E SID-1_RNA_chan PF13965.6 ELR16214.1 - 4.6 5.5 11.1 0.91 7.9 7.2 1.7 2 0 0 2 2 2 0 dsRNA-gated channel SID-1 Pkinase PF00069.25 ELR16215.1 - 2.4e-13 50.0 0.0 3.2e-13 49.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain F-box-like PF12937.7 ELR16216.1 - 0.0033 17.3 0.1 0.0049 16.7 0.1 1.3 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ELR16216.1 - 0.0049 16.7 0.1 0.0067 16.3 0.1 1.2 1 0 0 1 1 1 1 F-box domain DUF2514 PF10721.9 ELR16217.1 - 1.6 8.8 7.2 1.8 8.6 2.8 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2514) Bap31 PF05529.12 ELR16218.1 - 7.6e-15 55.0 0.8 1.3e-14 54.2 0.8 1.4 1 1 0 1 1 1 1 Bap31/Bap29 transmembrane region AAA_5 PF07728.14 ELR16219.1 - 2.6e-67 225.1 0.0 5.9e-24 84.6 0.0 5.2 5 0 0 5 5 5 4 AAA domain (dynein-related subfamily) AAA_lid_7 PF17867.1 ELR16219.1 - 7.9e-36 122.5 0.0 1e-18 67.5 0.0 3.6 3 0 0 3 3 3 2 Midasin AAA lid domain AAA_lid_5 PF17865.1 ELR16219.1 - 1.3e-32 112.0 0.0 3e-32 110.9 0.0 1.7 1 0 0 1 1 1 1 Midasin AAA lid domain AAA_7 PF12775.7 ELR16219.1 - 2.8e-17 62.8 0.1 1.1e-05 25.0 0.0 3.8 4 0 0 4 4 3 3 P-loop containing dynein motor region AAA_3 PF07726.11 ELR16219.1 - 6.8e-16 58.3 0.0 1.5e-05 24.9 0.0 4.5 4 0 0 4 4 4 3 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 ELR16219.1 - 3.4e-14 53.6 10.0 9.5e-05 22.8 3.6 5.2 3 2 1 4 4 4 3 AAA ATPase domain AAA PF00004.29 ELR16219.1 - 8.9e-13 48.8 0.0 0.0045 17.4 0.0 3.8 3 0 0 3 3 3 3 ATPase family associated with various cellular activities (AAA) TsaE PF02367.17 ELR16219.1 - 4.4e-11 42.9 2.0 0.014 15.4 0.1 3.4 3 0 0 3 3 3 3 Threonylcarbamoyl adenosine biosynthesis protein TsaE Dynein_heavy PF03028.15 ELR16219.1 - 8.3e-11 42.0 0.0 0.033 14.3 0.0 3.9 3 0 0 3 3 3 3 Dynein heavy chain region D6 P-loop domain AAA_6 PF12774.7 ELR16219.1 - 2.1e-10 40.1 0.1 0.0093 15.0 0.0 4.6 4 1 0 4 4 4 2 Hydrolytic ATP binding site of dynein motor region AAA_22 PF13401.6 ELR16219.1 - 3.2e-10 40.4 0.1 0.0023 18.2 0.0 4.3 4 1 0 4 4 3 2 AAA domain AAA_14 PF13173.6 ELR16219.1 - 2e-09 37.5 0.0 0.0013 18.8 0.0 5.3 5 0 0 5 5 5 1 AAA domain Sigma54_activat PF00158.26 ELR16219.1 - 1.1e-08 35.0 0.0 0.3 10.8 0.0 3.9 4 1 0 4 4 3 3 Sigma-54 interaction domain AAA_18 PF13238.6 ELR16219.1 - 5e-08 33.6 0.3 0.82 10.2 0.0 4.1 4 0 0 4 4 3 3 AAA domain ABC_tran PF00005.27 ELR16219.1 - 1e-07 32.5 0.2 0.047 14.2 0.1 3.6 3 0 0 3 3 3 2 ABC transporter Zeta_toxin PF06414.12 ELR16219.1 - 1.9e-07 30.6 0.3 0.76 9.0 0.0 4.7 4 0 0 4 4 4 1 Zeta toxin AAA_33 PF13671.6 ELR16219.1 - 4.6e-07 30.1 0.5 0.66 10.1 0.0 5.7 5 2 1 6 6 6 1 AAA domain T2SSE PF00437.20 ELR16219.1 - 1.1e-06 27.9 0.1 0.0077 15.3 0.0 3.3 3 0 0 3 3 3 1 Type II/IV secretion system protein RsgA_GTPase PF03193.16 ELR16219.1 - 5.2e-06 26.5 0.1 0.17 11.8 0.1 3.7 3 0 0 3 3 3 1 RsgA GTPase Sigma54_activ_2 PF14532.6 ELR16219.1 - 6.7e-06 26.3 0.1 0.066 13.3 0.0 3.5 3 0 0 3 3 3 2 Sigma-54 interaction domain RNA_helicase PF00910.22 ELR16219.1 - 9.7e-06 25.9 0.0 0.35 11.3 0.0 3.8 3 0 0 3 3 3 1 RNA helicase NACHT PF05729.12 ELR16219.1 - 1.2e-05 25.3 0.0 0.67 9.9 0.0 4.1 4 0 0 4 4 3 2 NACHT domain AAA_30 PF13604.6 ELR16219.1 - 4.5e-05 23.3 0.1 6.6 6.4 0.0 4.8 5 1 0 5 5 5 0 AAA domain TniB PF05621.11 ELR16219.1 - 5.7e-05 22.6 0.3 0.89 8.9 0.0 3.8 4 0 0 4 4 3 1 Bacterial TniB protein Mg_chelatase PF01078.21 ELR16219.1 - 0.00012 21.5 0.2 5.2 6.4 0.0 5.0 5 0 0 5 5 5 0 Magnesium chelatase, subunit ChlI AAA_28 PF13521.6 ELR16219.1 - 0.00027 21.2 0.1 0.67 10.2 0.0 3.7 3 0 0 3 3 3 1 AAA domain DUF815 PF05673.13 ELR16219.1 - 0.0005 19.3 0.1 0.93 8.6 0.0 3.3 3 0 0 3 3 3 1 Protein of unknown function (DUF815) AAA_29 PF13555.6 ELR16219.1 - 0.00055 19.6 0.1 7.5 6.4 0.0 3.5 3 0 0 3 3 3 0 P-loop containing region of AAA domain AAA_25 PF13481.6 ELR16219.1 - 0.00064 19.3 0.2 0.63 9.6 0.0 3.3 3 0 0 3 3 3 1 AAA domain dNK PF01712.19 ELR16219.1 - 0.0011 18.9 0.7 4.9 7.0 0.0 3.4 3 0 0 3 3 3 0 Deoxynucleoside kinase Roc PF08477.13 ELR16219.1 - 0.002 18.3 0.2 5.6 7.2 0.0 3.6 3 0 0 3 3 3 0 Ras of Complex, Roc, domain of DAPkinase AAA_8 PF12780.7 ELR16219.1 - 0.0026 17.1 0.1 9.5 5.5 0.0 3.5 3 0 0 3 3 3 0 P-loop containing dynein motor region D4 ResIII PF04851.15 ELR16219.1 - 0.0042 17.1 1.0 0.96 9.4 0.1 3.5 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit AAA_9 PF12781.7 ELR16219.1 - 0.0046 16.1 0.0 7.8 5.6 0.0 4.3 4 0 0 4 4 4 0 ATP-binding dynein motor region cobW PF02492.19 ELR16219.1 - 0.0059 16.2 0.0 2.9 7.4 0.0 3.4 3 0 0 3 3 3 1 CobW/HypB/UreG, nucleotide-binding domain PduV-EutP PF10662.9 ELR16219.1 - 0.0063 16.3 0.1 3.4 7.4 0.0 3.3 3 0 0 3 3 3 1 Ethanolamine utilisation - propanediol utilisation AAA_11 PF13086.6 ELR16219.1 - 0.0065 16.3 7.2 0.48 10.2 5.3 3.1 3 1 0 3 3 3 1 AAA domain CPT PF07931.12 ELR16219.1 - 0.0084 16.0 0.1 2.8 7.8 0.0 4.1 3 1 0 3 3 3 1 Chloramphenicol phosphotransferase-like protein RuvB_N PF05496.12 ELR16219.1 - 0.0089 15.8 0.1 22 4.8 0.0 3.4 3 0 0 3 3 3 0 Holliday junction DNA helicase RuvB P-loop domain ATP-synt_ab PF00006.25 ELR16219.1 - 0.0094 15.6 0.0 3.7 7.1 0.0 3.0 3 0 0 3 3 3 0 ATP synthase alpha/beta family, nucleotide-binding domain AAA_2 PF07724.14 ELR16219.1 - 0.0099 16.0 0.0 7.2 6.7 0.0 3.7 4 0 0 4 4 3 0 AAA domain (Cdc48 subfamily) ATPase_2 PF01637.18 ELR16219.1 - 0.021 14.8 0.0 19 5.1 0.0 3.6 3 0 0 3 3 3 0 ATPase domain predominantly from Archaea AAA_19 PF13245.6 ELR16219.1 - 0.036 14.4 5.9 8.1 6.8 0.1 4.5 4 2 0 4 4 3 0 AAA domain SRP54 PF00448.22 ELR16219.1 - 0.036 13.7 0.1 4.5 6.9 0.0 2.9 3 0 0 3 3 3 0 SRP54-type protein, GTPase domain MMR_HSR1 PF01926.23 ELR16219.1 - 0.048 13.7 0.0 31 4.7 0.0 3.4 3 0 0 3 3 3 0 50S ribosome-binding GTPase TIP49 PF06068.13 ELR16219.1 - 0.054 12.7 0.0 12 5.0 0.1 3.0 3 0 0 3 3 3 0 TIP49 P-loop domain IPT PF01745.16 ELR16219.1 - 0.068 12.6 1.3 5.1 6.4 0.0 3.2 4 0 0 4 4 3 0 Isopentenyl transferase SRPRB PF09439.10 ELR16219.1 - 0.14 11.6 6.6 1.3 8.4 0.9 3.3 4 0 0 4 4 3 0 Signal recognition particle receptor beta subunit NTPase_1 PF03266.15 ELR16219.1 - 0.2 11.5 0.4 52 3.7 0.0 3.2 3 0 0 3 3 3 0 NTPase DUF1180 PF06679.12 ELR16219.1 - 0.21 12.0 2.3 0.43 11.0 2.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) ETC_C1_NDUFA5 PF04716.14 ELR16220.1 - 0.011 15.6 0.0 0.016 15.0 0.0 1.2 1 0 0 1 1 1 0 ETC complex I subunit conserved region KduI PF04962.12 ELR16221.1 - 0.14 11.4 0.2 0.24 10.7 0.2 1.3 1 0 0 1 1 1 0 KduI/IolB family Ras PF00071.22 ELR16222.1 - 1.5e-47 161.3 0.0 2.2e-47 160.7 0.0 1.3 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR16222.1 - 2.6e-27 95.4 0.0 4.5e-27 94.6 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ank_5 PF13857.6 ELR16222.1 - 6.6e-17 61.4 0.7 2.1e-08 34.3 0.0 3.3 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 ELR16222.1 - 3e-15 56.6 0.0 3.3e-13 50.0 0.0 2.5 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank PF00023.30 ELR16222.1 - 5.8e-15 55.0 0.7 4.1e-05 23.8 0.1 4.3 4 0 0 4 4 4 2 Ankyrin repeat Ank_4 PF13637.6 ELR16222.1 - 1.7e-14 53.9 0.0 5.4e-10 39.6 0.0 3.5 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 ELR16222.1 - 4.6e-14 51.1 0.3 0.00023 21.3 0.0 4.0 3 0 0 3 3 3 2 Ankyrin repeat Arf PF00025.21 ELR16222.1 - 1.4e-09 37.7 0.0 2.1e-09 37.1 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family F-box-like PF12937.7 ELR16222.1 - 1e-05 25.3 0.4 1.8e-05 24.6 0.4 1.4 1 0 0 1 1 1 1 F-box-like F-box_4 PF15966.5 ELR16222.1 - 2.2e-05 24.3 0.1 4.2e-05 23.4 0.1 1.4 1 0 0 1 1 1 1 F-box F-box PF00646.33 ELR16222.1 - 0.00011 22.0 1.2 0.00019 21.2 1.2 1.4 1 0 0 1 1 1 1 F-box domain Gtr1_RagA PF04670.12 ELR16222.1 - 0.0038 16.6 0.0 0.006 16.0 0.0 1.3 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region AAA_22 PF13401.6 ELR16222.1 - 0.023 15.0 0.0 0.16 12.2 0.0 2.1 1 1 0 1 1 1 0 AAA domain AAA_7 PF12775.7 ELR16222.1 - 0.24 10.9 0.0 0.41 10.1 0.0 1.2 1 0 0 1 1 1 0 P-loop containing dynein motor region Exo_endo_phos PF03372.23 ELR16224.1 - 0.0041 16.7 0.0 0.0051 16.4 0.0 1.2 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family VWA_2 PF13519.6 ELR16226.1 - 1.1e-06 29.3 0.0 0.0018 18.9 0.0 3.8 2 1 0 2 2 2 1 von Willebrand factor type A domain Sec23_trunk PF04811.15 ELR16226.1 - 0.00017 21.2 0.0 0.00073 19.2 0.0 1.9 1 1 0 1 1 1 1 Sec23/Sec24 trunk domain VWA PF00092.28 ELR16226.1 - 0.0018 18.6 0.0 4.5 7.5 0.0 3.2 3 0 0 3 3 3 2 von Willebrand factor type A domain VWA_CoxE PF05762.14 ELR16226.1 - 0.02 14.3 0.0 0.29 10.5 0.0 2.3 2 0 0 2 2 2 0 VWA domain containing CoxE-like protein zf-Sec23_Sec24 PF04810.15 ELR16226.1 - 0.04 14.0 0.5 0.11 12.6 0.5 1.7 1 1 0 1 1 1 0 Sec23/Sec24 zinc finger C1_1 PF00130.22 ELR16226.1 - 0.14 12.1 0.2 0.29 11.0 0.2 1.5 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) BAG PF02179.16 ELR16228.1 - 3.4e-10 40.2 1.0 5.5e-10 39.5 1.0 1.5 1 1 0 1 1 1 1 BAG domain Peptidase_M3_N PF08439.10 ELR16228.1 - 0.28 11.5 0.3 0.28 11.5 0.3 1.9 2 1 0 2 2 2 0 Oligopeptidase F SLX9 PF15341.6 ELR16228.1 - 1.5 9.3 6.4 0.65 10.4 1.8 2.1 1 1 1 2 2 2 0 Ribosome biogenesis protein SLX9 Methyltransf_3 PF01596.17 ELR16229.1 - 1.5e-36 125.6 0.0 1.9e-36 125.3 0.0 1.1 1 0 0 1 1 1 1 O-methyltransferase Methyltransf_24 PF13578.6 ELR16229.1 - 6.9e-16 59.2 0.0 1.6e-15 58.0 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain GCD14 PF08704.10 ELR16229.1 - 0.14 11.8 0.0 0.21 11.2 0.0 1.3 1 0 0 1 1 1 0 tRNA methyltransferase complex GCD14 subunit PCMT PF01135.19 ELR16229.1 - 0.17 11.6 0.0 0.25 11.1 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) DCAF15_WD40 PF14939.6 ELR16230.1 - 0.004 16.8 0.0 0.26 10.9 0.0 2.2 2 0 0 2 2 2 2 DDB1-and CUL4-substrate receptor 15, WD repeat Tegument_dsDNA PF12818.7 ELR16230.1 - 0.014 14.6 0.0 0.082 12.0 0.0 1.9 2 0 0 2 2 2 0 dsDNA viral tegument protein Pyr_redox_dim PF02852.22 ELR16231.1 - 3.2e-38 130.4 0.2 3.8e-38 130.1 0.2 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox_2 PF07992.14 ELR16233.1 - 1.3e-65 221.5 1.1 1.6e-65 221.2 1.1 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.22 ELR16233.1 - 6.9e-37 126.1 0.2 1.3e-36 125.2 0.2 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.27 ELR16233.1 - 8.7e-19 67.9 0.5 5.1e-18 65.4 0.0 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 ELR16233.1 - 9.5e-15 54.6 0.1 9.5e-15 54.6 0.1 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 ELR16233.1 - 0.00033 19.5 3.8 0.031 13.0 0.0 2.6 3 0 0 3 3 3 2 HI0933-like protein FAD_oxidored PF12831.7 ELR16233.1 - 0.00091 18.7 0.4 0.0088 15.4 0.1 2.1 2 0 0 2 2 2 1 FAD dependent oxidoreductase K_oxygenase PF13434.6 ELR16233.1 - 0.0013 18.0 0.1 0.16 11.1 0.0 2.1 1 1 1 2 2 2 2 L-lysine 6-monooxygenase (NADPH-requiring) Thi4 PF01946.17 ELR16233.1 - 0.021 14.1 0.1 0.05 12.8 0.1 1.7 1 0 0 1 1 1 0 Thi4 family GIDA PF01134.22 ELR16233.1 - 0.023 13.8 2.5 0.059 12.4 0.5 2.4 3 0 0 3 3 3 0 Glucose inhibited division protein A NAD_binding_9 PF13454.6 ELR16233.1 - 0.034 14.1 0.1 0.094 12.7 0.1 1.8 1 0 0 1 1 1 0 FAD-NAD(P)-binding AlaDh_PNT_C PF01262.21 ELR16233.1 - 0.21 10.8 4.3 3.1 7.0 0.2 3.1 3 0 0 3 3 3 0 Alanine dehydrogenase/PNT, C-terminal domain FAD_binding_2 PF00890.24 ELR16233.1 - 0.6 9.1 6.1 5.7 5.9 3.4 3.1 2 1 0 3 3 3 0 FAD binding domain Gcd10p PF04189.13 ELR16234.1 - 5.3e-58 196.5 0.0 8.8e-58 195.8 0.0 1.3 1 0 0 1 1 1 1 Gcd10p family SH3_1 PF00018.28 ELR16235.1 - 1.5e-44 149.3 4.0 2.1e-15 56.0 0.1 3.5 3 0 0 3 3 3 3 SH3 domain SH3_9 PF14604.6 ELR16235.1 - 4.6e-42 141.7 5.6 2.1e-14 53.1 0.1 3.5 3 0 0 3 3 3 3 Variant SH3 domain SH3_2 PF07653.17 ELR16235.1 - 1.9e-34 117.1 0.0 2.5e-12 46.3 0.0 3.6 3 0 0 3 3 3 3 Variant SH3 domain PH PF00169.29 ELR16235.1 - 1.9e-10 41.2 0.0 4.4e-10 40.0 0.0 1.6 1 0 0 1 1 1 1 PH domain SH3_10 PF17902.1 ELR16235.1 - 0.0026 17.8 0.0 1.4 9.1 0.0 3.5 3 0 0 3 3 3 1 SH3 domain Actin PF00022.19 ELR16238.1 - 2.4e-16 59.3 0.0 4.8e-14 51.8 0.0 2.3 2 1 0 2 2 2 2 Actin SWIM PF04434.17 ELR16240.1 - 0.00033 20.2 0.8 0.00073 19.2 0.8 1.6 1 0 0 1 1 1 1 SWIM zinc finger Toxin_7 PF05980.12 ELR16240.1 - 0.11 12.8 1.5 0.23 11.8 1.5 1.6 1 0 0 1 1 1 0 Toxin 7 Mito_carr PF00153.27 ELR16242.1 - 2.8e-09 36.7 0.0 2.6e-06 27.2 0.0 2.3 2 0 0 2 2 2 2 Mitochondrial carrier protein YL1 PF05764.13 ELR16243.1 - 1.2e-09 38.7 3.0 1.3e-09 38.6 3.0 1.0 1 0 0 1 1 1 1 YL1 nuclear protein PRKCSH_1 PF13015.6 ELR16244.1 - 1.9e-21 76.4 0.0 1.9e-21 76.4 0.0 1.0 1 0 0 1 1 1 1 Glucosidase II beta subunit-like protein CIMR PF00878.18 ELR16244.1 - 0.0014 18.7 0.0 0.0016 18.6 0.0 1.1 1 0 0 1 1 1 1 Cation-independent mannose-6-phosphate receptor repeat ATG27 PF09451.10 ELR16244.1 - 0.0034 17.3 0.1 0.0037 17.2 0.1 1.0 1 0 0 1 1 1 1 Autophagy-related protein 27 NAPRTase_C PF17956.1 ELR16244.1 - 0.15 12.5 0.1 0.17 12.3 0.1 1.2 1 1 0 1 1 1 0 Nicotinate phosphoribosyltransferase C-terminal domain COesterase PF00135.28 ELR16245.1 - 9.4e-105 351.4 0.0 1.3e-104 351.0 0.0 1.1 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 ELR16245.1 - 0.00014 21.8 0.4 0.00064 19.6 0.4 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold Say1_Mug180 PF10340.9 ELR16245.1 - 0.22 10.3 0.0 4.4 6.1 0.0 2.1 2 0 0 2 2 2 0 Steryl acetyl hydrolase RFX_DNA_binding PF02257.15 ELR16246.1 - 6e-14 52.4 0.0 1.1e-13 51.6 0.0 1.4 1 0 0 1 1 1 1 RFX DNA-binding domain CCSAP PF15748.5 ELR16246.1 - 0.0012 19.1 5.4 0.0016 18.6 5.4 1.1 1 0 0 1 1 1 1 Centriole, cilia and spindle-associated Pox_D5 PF03288.16 ELR16246.1 - 0.011 16.2 0.0 0.022 15.2 0.0 1.4 1 0 0 1 1 1 0 Poxvirus D5 protein-like DUF4551 PF15087.6 ELR16246.1 - 0.63 8.8 2.6 0.99 8.2 2.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) DLEU7 PF15760.5 ELR16246.1 - 4 6.9 5.9 7.1 6.1 5.9 1.4 1 0 0 1 1 1 0 Leukemia-associated protein 7 TAP_C PF03943.13 ELR16248.1 - 3.8e-15 55.3 0.0 8.2e-15 54.2 0.0 1.6 1 0 0 1 1 1 1 TAP C-terminal domain NTF2 PF02136.20 ELR16248.1 - 1.1e-07 32.5 0.0 3.6e-07 30.8 0.0 1.9 1 1 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain LRR_9 PF14580.6 ELR16248.1 - 6e-06 25.9 0.4 1.1e-05 25.0 0.4 1.3 1 0 0 1 1 1 1 Leucine-rich repeat UBA_4 PF14555.6 ELR16248.1 - 1.6e-05 24.6 0.0 4.5e-05 23.2 0.0 1.8 1 0 0 1 1 1 1 UBA-like domain LRR_4 PF12799.7 ELR16248.1 - 0.0047 17.3 8.0 4.4 7.9 0.0 3.2 2 1 0 3 3 3 2 Leucine Rich repeats (2 copies) RRM_9 PF18444.1 ELR16248.1 - 0.0086 15.9 0.1 0.024 14.5 0.1 1.8 1 0 0 1 1 1 1 RNA recognition motif LRR_8 PF13855.6 ELR16248.1 - 0.021 14.6 7.1 0.077 12.8 6.6 2.3 1 1 1 2 2 2 0 Leucine rich repeat LRR_6 PF13516.6 ELR16248.1 - 0.78 10.0 2.3 51 4.3 0.0 3.6 4 0 0 4 4 4 0 Leucine Rich repeat Phage_holin_3_6 PF07332.11 ELR16249.1 - 0.0023 17.9 1.4 0.0023 17.9 1.4 4.6 5 0 0 5 5 5 1 Putative Actinobacterial Holin-X, holin superfamily III GvpK PF05121.12 ELR16249.1 - 0.051 13.6 4.2 2.8 8.1 1.0 2.7 2 0 0 2 2 2 0 Gas vesicle protein K OAD_gamma PF04277.13 ELR16249.1 - 0.082 13.5 0.1 0.77 10.4 0.1 2.6 2 0 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain CobD_Cbib PF03186.13 ELR16249.1 - 0.47 9.6 4.9 0.44 9.7 0.1 2.4 2 0 0 2 2 2 0 CobD/Cbib protein EamA PF00892.20 ELR16251.1 - 1.8e-13 50.9 41.4 1.5e-07 31.6 17.4 3.2 3 0 0 3 3 3 3 EamA-like transporter family SLC35F PF06027.12 ELR16251.1 - 4.4e-07 29.7 12.6 7.9e-07 28.9 12.6 1.3 1 0 0 1 1 1 1 Solute carrier family 35 UAA PF08449.11 ELR16251.1 - 0.088 12.0 14.3 0.4 9.8 10.8 2.6 2 1 0 2 2 2 0 UAA transporter family DUF3955 PF13127.6 ELR16251.1 - 2.6 7.9 9.4 0.66 9.8 5.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3955) cNMP_binding PF00027.29 ELR16252.1 - 7.7e-47 157.3 0.2 3.1e-22 78.5 0.0 2.4 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain DUF5586 PF17824.1 ELR16252.1 - 0.11 11.6 0.0 0.17 10.9 0.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5586) SR-25 PF10500.9 ELR16252.1 - 3.3 7.2 9.2 5.2 6.6 9.2 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein FlaC_arch PF05377.11 ELR16254.1 - 4.7e-06 26.9 11.5 0.4 11.1 0.5 4.0 3 0 0 3 3 3 3 Flagella accessory protein C (FlaC) ATG16 PF08614.11 ELR16254.1 - 0.0092 16.2 13.6 0.0092 16.2 13.6 3.3 1 1 2 3 3 3 1 Autophagy protein 16 (ATG16) Mce4_CUP1 PF11887.8 ELR16254.1 - 0.051 13.0 0.5 0.11 11.9 0.5 1.7 1 0 0 1 1 1 0 Cholesterol uptake porter CUP1 of Mce4, putative Pkinase_Tyr PF07714.17 ELR16256.1 - 5.3e-45 153.7 0.0 6.1e-45 153.5 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ELR16256.1 - 4.9e-42 144.1 0.0 6.2e-42 143.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.23 ELR16256.1 - 1.3e-06 28.5 0.0 2.1e-06 27.9 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 ELR16256.1 - 0.0011 18.0 0.0 0.0016 17.5 0.0 1.2 1 0 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 ELR16256.1 - 0.022 14.1 0.0 0.031 13.6 0.0 1.2 1 0 0 1 1 1 0 Kinase-like Kdo PF06293.14 ELR16256.1 - 0.09 12.1 0.0 0.13 11.6 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Seadorna_VP7 PF07387.11 ELR16256.1 - 0.091 11.8 0.0 0.13 11.2 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 TPR_17 PF13431.6 ELR16258.1 - 2.9e-12 46.1 0.3 0.019 15.3 0.0 4.9 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_11 PF13414.6 ELR16258.1 - 1.1e-11 44.2 4.1 1.1e-05 25.0 0.3 4.5 3 1 1 4 4 4 2 TPR repeat CLU PF13236.6 ELR16258.1 - 1.7e-09 37.9 0.0 3.9e-09 36.7 0.0 1.5 1 0 0 1 1 1 1 Clustered mitochondria eIF3_p135 PF12807.7 ELR16258.1 - 3.1e-07 30.6 0.3 7.7e-07 29.3 0.3 1.6 1 0 0 1 1 1 1 Translation initiation factor eIF3 subunit 135 TPR_2 PF07719.17 ELR16258.1 - 1.5e-06 27.9 4.4 0.0063 16.5 0.0 5.4 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_16 PF13432.6 ELR16258.1 - 2.6e-06 28.0 2.8 0.00018 22.1 0.0 3.9 2 2 2 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.6 ELR16258.1 - 4.4e-05 24.0 7.4 0.0071 17.1 0.1 5.5 5 1 1 6 6 6 1 Tetratricopeptide repeat TPR_1 PF00515.28 ELR16258.1 - 0.0014 18.4 0.4 2.5 8.1 0.0 4.4 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_21 PF09976.9 ELR16258.1 - 0.013 15.2 0.0 0.051 13.3 0.0 2.0 1 0 0 1 1 1 0 Tetratricopeptide repeat-like domain TPR_19 PF14559.6 ELR16258.1 - 0.03 14.8 7.0 0.2 12.2 0.4 4.2 4 0 0 4 4 4 0 Tetratricopeptide repeat LRR_6 PF13516.6 ELR16258.1 - 0.039 14.0 0.2 44 4.5 0.0 4.6 4 0 0 4 4 4 0 Leucine Rich repeat TOM20_plant PF06552.12 ELR16258.1 - 0.04 13.7 0.1 0.51 10.1 0.1 2.5 1 1 1 2 2 2 0 Plant specific mitochondrial import receptor subunit TOM20 Clusterin PF01093.17 ELR16259.1 - 0.066 12.2 0.0 0.091 11.8 0.0 1.1 1 0 0 1 1 1 0 Clusterin Tubulin PF00091.25 ELR16260.1 - 2e-28 100.0 0.0 2.3e-28 99.7 0.0 1.1 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_3 PF14881.6 ELR16260.1 - 3.7e-06 26.7 0.0 5.4e-06 26.2 0.0 1.2 1 0 0 1 1 1 1 Tubulin domain F-box-like PF12937.7 ELR16260.1 - 5.5e-05 23.0 0.5 5.5e-05 23.0 0.5 1.8 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 ELR16260.1 - 0.00033 20.5 0.1 0.00073 19.3 0.1 1.5 1 0 0 1 1 1 1 F-box domain p450 PF00067.22 ELR16263.1 - 3.7e-71 240.2 0.0 4.7e-64 216.8 0.0 2.0 1 1 1 2 2 2 2 Cytochrome P450 UQ_con PF00179.26 ELR16264.1 - 0.048 13.3 0.1 0.098 12.3 0.1 1.5 1 0 0 1 1 1 0 Ubiquitin-conjugating enzyme Pkinase PF00069.25 ELR16265.1 - 2.9e-59 200.6 0.0 2.9e-44 151.4 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ELR16265.1 - 1.8e-30 106.1 0.0 2.9e-30 105.4 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ELR16265.1 - 2e-09 37.2 0.0 3.2e-09 36.5 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 ELR16265.1 - 0.0012 18.2 0.1 0.0022 17.4 0.1 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 ELR16265.1 - 0.002 18.1 0.2 0.0037 17.2 0.2 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family Peptidase_S49_N PF08496.10 ELR16265.1 - 4.2 7.4 8.8 9.5 6.3 8.4 1.8 1 1 0 1 1 1 0 Peptidase family S49 N-terminal DNA_pol_phi PF04931.13 ELR16265.1 - 5.7 4.9 19.8 9.8 4.1 19.8 1.2 1 0 0 1 1 1 0 DNA polymerase phi CS PF04969.16 ELR16266.1 - 4.2e-14 53.3 1.2 6.5e-14 52.7 1.2 1.3 1 0 0 1 1 1 1 CS domain zf-C3HC4_3 PF13920.6 ELR16267.1 - 8.9e-12 44.7 11.3 1.4e-11 44.0 11.3 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) VWA_2 PF13519.6 ELR16267.1 - 5.1e-11 43.2 0.0 4.6e-10 40.1 0.0 2.5 1 1 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.28 ELR16267.1 - 1.6e-08 35.0 0.3 8.6e-07 29.4 0.0 2.3 2 0 0 2 2 2 1 von Willebrand factor type A domain Prok-RING_4 PF14447.6 ELR16267.1 - 4.1e-06 26.5 11.1 8.3e-06 25.6 11.1 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 VWA_3 PF13768.6 ELR16267.1 - 0.018 15.0 0.0 0.035 14.0 0.0 1.5 1 0 0 1 1 1 0 von Willebrand factor type A domain zf-RING_5 PF14634.6 ELR16267.1 - 0.17 11.9 13.5 0.31 11.1 13.5 1.4 1 0 0 1 1 1 0 zinc-RING finger domain Nucleo_P87 PF07267.11 ELR16267.1 - 3 6.6 8.7 0.16 10.8 3.2 1.5 2 0 0 2 2 2 0 Nucleopolyhedrovirus capsid protein P87 IRK_C PF17655.1 ELR16268.1 - 6e-22 78.1 0.0 1.6e-21 76.7 0.0 1.7 2 0 0 2 2 2 1 Inward rectifier potassium channel C-terminal domain IRK PF01007.20 ELR16268.1 - 2.6e-12 46.7 4.8 5.1e-12 45.8 4.8 1.4 1 1 0 1 1 1 1 Inward rectifier potassium channel transmembrane domain Ion_trans_2 PF07885.16 ELR16268.1 - 1.7e-07 31.1 6.1 3.1e-07 30.3 6.1 1.5 1 0 0 1 1 1 1 Ion channel IMUP PF15761.5 ELR16269.1 - 0.015 16.0 2.6 0.024 15.3 2.6 1.3 1 0 0 1 1 1 0 Immortalisation up-regulated protein SR-25 PF10500.9 ELR16269.1 - 0.022 14.4 0.4 0.026 14.1 0.4 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Zip PF02535.22 ELR16269.1 - 0.14 11.4 0.7 0.13 11.4 0.7 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter EI24 PF07264.11 ELR16270.1 - 0.00045 20.5 2.9 0.31 11.3 0.1 2.3 1 1 1 2 2 2 2 Etoposide-induced protein 2.4 (EI24) ECF_trnsprt PF12822.7 ELR16270.1 - 0.003 17.7 0.8 0.013 15.6 0.8 1.9 1 1 0 1 1 1 1 ECF transporter, substrate-specific component ABC2_membrane_3 PF12698.7 ELR16270.1 - 0.056 12.5 6.4 0.21 10.6 0.6 2.6 3 0 0 3 3 3 0 ABC-2 family transporter protein Tetraspanin PF00335.20 ELR16270.1 - 0.069 12.8 4.1 0.13 11.9 4.1 1.6 1 1 0 1 1 1 0 Tetraspanin family Shisa PF13908.6 ELR16270.1 - 0.074 13.3 1.0 14 5.9 0.0 2.5 3 0 0 3 3 2 0 Wnt and FGF inhibitory regulator Myc_target_1 PF15179.6 ELR16270.1 - 0.2 11.5 0.4 7 6.5 0.5 2.3 2 0 0 2 2 2 0 Myc target protein 1 DUF4834 PF16118.5 ELR16270.1 - 0.74 10.8 0.0 0.74 10.8 0.0 3.7 5 1 0 5 5 4 0 Domain of unknown function (DUF4834) DUF3292 PF11696.8 ELR16270.1 - 2 6.7 6.7 2.9 6.1 6.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3292) EphA2_TM PF14575.6 ELR16270.1 - 2.8 8.9 4.6 29 5.6 0.0 3.9 3 2 0 3 3 3 0 Ephrin type-A receptor 2 transmembrane domain Syntaxin-6_N PF09177.11 ELR16270.1 - 3.6 8.2 7.9 0.71 10.5 3.5 2.1 2 1 0 2 2 2 0 Syntaxin 6, N-terminal DUF883 PF05957.13 ELR16270.1 - 5.5 7.7 8.6 2.4 8.8 0.8 3.3 3 1 0 3 3 3 0 Bacterial protein of unknown function (DUF883) Clat_adaptor_s PF01217.20 ELR16271.1 - 2.9e-26 92.1 0.3 3.9e-26 91.7 0.3 1.1 1 0 0 1 1 1 1 Clathrin adaptor complex small chain IMS PF00817.20 ELR16272.1 - 1.3e-36 125.8 0.1 3.6e-20 72.5 0.0 2.4 2 0 0 2 2 2 2 impB/mucB/samB family IMS_C PF11799.8 ELR16272.1 - 3.5e-07 30.9 0.0 7.9e-07 29.8 0.0 1.6 1 0 0 1 1 1 1 impB/mucB/samB family C-terminal domain DUF1993 PF09351.10 ELR16272.1 - 0.19 11.9 0.2 0.66 10.1 0.1 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF1993) MORN PF02493.20 ELR16273.1 - 1.6e-24 84.3 43.0 4.2e-07 29.5 2.4 8.5 8 0 0 8 8 8 6 MORN repeat VPS9 PF02204.18 ELR16273.1 - 9.9e-14 51.4 0.0 2.2e-13 50.3 0.0 1.6 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain Glyco_hydro_3_C PF01915.22 ELR16273.1 - 0.053 13.5 0.0 0.12 12.3 0.0 1.5 1 0 0 1 1 1 0 Glycosyl hydrolase family 3 C-terminal domain CCDC53 PF10152.9 ELR16273.1 - 0.77 10.2 2.7 1.1 9.7 0.5 2.1 2 0 0 2 2 2 0 Subunit CCDC53 of WASH complex SRF-TF PF00319.18 ELR16274.1 - 4.1e-21 74.2 0.1 5.9e-21 73.7 0.1 1.2 1 0 0 1 1 1 1 SRF-type transcription factor (DNA-binding and dimerisation domain) GRAM PF02893.20 ELR16275.1 - 2.9e-10 40.0 0.0 6.2e-10 39.0 0.0 1.6 1 0 0 1 1 1 1 GRAM domain TROVE PF05731.11 ELR16276.1 - 4.7e-93 312.6 0.6 6.4e-93 312.2 0.6 1.1 1 0 0 1 1 1 1 TROVE domain DUF2828 PF11443.8 ELR16276.1 - 0.00013 20.3 0.1 0.0015 16.7 0.0 2.4 3 1 0 3 3 3 1 Domain of unknown function (DUF2828) VWA_CoxE PF05762.14 ELR16276.1 - 0.056 12.8 0.5 1.5 8.2 0.1 3.1 2 2 1 3 3 3 0 VWA domain containing CoxE-like protein RNase_HII PF01351.18 ELR16278.1 - 3.2e-35 121.8 0.0 4.3e-35 121.4 0.0 1.1 1 0 0 1 1 1 1 Ribonuclease HII DUF4938 PF16292.5 ELR16278.1 - 0.071 12.4 0.0 0.17 11.1 0.0 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4938) NmrA PF05368.13 ELR16280.1 - 4.4e-12 46.1 0.2 1.1e-07 31.6 0.6 2.2 1 1 1 2 2 2 2 NmrA-like family NAD_binding_10 PF13460.6 ELR16280.1 - 3.4e-08 33.6 0.3 0.00084 19.3 0.7 2.5 2 1 1 3 3 3 2 NAD(P)H-binding Epimerase PF01370.21 ELR16280.1 - 0.0027 17.2 0.0 0.0036 16.8 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Rossmann-like PF10727.9 ELR16280.1 - 0.0045 16.8 0.3 0.0045 16.8 0.3 2.1 3 0 0 3 3 3 1 Rossmann-like domain F420_oxidored PF03807.17 ELR16280.1 - 0.0094 16.5 0.1 0.02 15.4 0.1 1.6 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent RmlD_sub_bind PF04321.17 ELR16280.1 - 0.039 13.1 0.3 0.074 12.1 0.1 1.6 2 0 0 2 2 2 0 RmlD substrate binding domain Glyco_transf_4 PF13439.6 ELR16280.1 - 0.041 13.9 0.0 0.26 11.3 0.0 2.0 2 0 0 2 2 2 0 Glycosyltransferase Family 4 adh_short PF00106.25 ELR16280.1 - 0.093 12.2 0.1 0.15 11.5 0.1 1.4 1 0 0 1 1 1 0 short chain dehydrogenase DFP PF04127.15 ELR16280.1 - 0.13 12.1 0.1 0.21 11.4 0.1 1.3 1 0 0 1 1 1 0 DNA / pantothenate metabolism flavoprotein DUF1196 PF06709.11 ELR16283.1 - 0.15 12.3 0.0 8.3 6.6 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1196) B12D PF06522.11 ELR16284.1 - 1.6e-06 27.8 0.2 2.5e-06 27.2 0.2 1.3 1 0 0 1 1 1 1 NADH-ubiquinone reductase complex 1 MLRQ subunit HCV_core PF01542.18 ELR16284.1 - 0.075 13.4 0.2 0.11 12.9 0.2 1.2 1 0 0 1 1 1 0 Hepatitis C virus core protein DENN PF02141.21 ELR16285.1 - 1.4e-44 152.3 4.6 6.7e-37 127.2 1.3 2.6 2 1 1 3 3 3 2 DENN (AEX-3) domain PH PF00169.29 ELR16285.1 - 7.5e-14 52.1 0.0 2.3e-13 50.6 0.0 1.8 2 0 0 2 2 2 1 PH domain uDENN PF03456.18 ELR16285.1 - 1.2e-08 35.5 0.0 3.9e-08 33.9 0.0 2.0 1 1 0 1 1 1 1 uDENN domain dDENN PF03455.19 ELR16285.1 - 0.0017 18.3 0.3 0.0038 17.2 0.3 1.6 1 0 0 1 1 1 1 dDENN domain PH_11 PF15413.6 ELR16285.1 - 0.0017 18.8 0.0 0.0059 17.0 0.0 1.9 1 1 0 1 1 1 1 Pleckstrin homology domain PX PF00787.24 ELR16286.1 - 1.1e-09 38.3 0.0 3e-09 36.8 0.0 1.7 1 0 0 1 1 1 1 PX domain PH PF00169.29 ELR16286.1 - 9.8e-08 32.5 0.0 3.9e-07 30.5 0.0 2.0 1 0 0 1 1 1 1 PH domain RhoGAP PF00620.27 ELR16286.1 - 0.0049 16.7 0.0 0.015 15.1 0.0 1.8 1 0 0 1 1 1 1 RhoGAP domain PH_11 PF15413.6 ELR16286.1 - 0.011 16.1 1.2 0.045 14.2 0.0 2.7 2 0 0 2 2 2 0 Pleckstrin homology domain Aminotran_4 PF01063.19 ELR16287.1 - 2.9e-41 141.8 0.0 3.5e-41 141.5 0.0 1.1 1 0 0 1 1 1 1 Amino-transferase class IV RFX_DNA_binding PF02257.15 ELR16288.1 - 2.6e-20 72.8 0.0 6.7e-20 71.5 0.0 1.7 1 0 0 1 1 1 1 RFX DNA-binding domain Cdc6_C PF09079.11 ELR16288.1 - 0.035 14.1 0.0 0.079 13.0 0.0 1.5 1 0 0 1 1 1 0 CDC6, C terminal winged helix domain CK2S PF15011.6 ELR16289.1 - 2e-15 57.0 0.0 2.6e-15 56.7 0.0 1.1 1 0 0 1 1 1 1 Casein Kinase 2 substrate DUF3287 PF11690.8 ELR16289.1 - 0.066 12.9 1.1 6.4 6.5 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3287) Pkinase_Tyr PF07714.17 ELR16290.1 - 7.1e-100 333.6 0.0 1.3e-60 204.9 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 ELR16290.1 - 5.3e-86 288.2 0.0 7.8e-47 159.8 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain PBP_like_2 PF12849.7 ELR16290.1 - 4.6e-33 115.1 6.6 5.1e-19 69.0 2.0 2.3 2 0 0 2 2 2 2 PBP superfamily domain Guanylate_cyc PF00211.20 ELR16290.1 - 1.9e-13 50.4 0.0 3.8e-13 49.4 0.0 1.4 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain APH PF01636.23 ELR16290.1 - 3.1e-07 30.5 0.9 0.00023 21.2 0.0 3.0 2 1 0 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.14 ELR16290.1 - 6.8e-05 22.3 0.2 0.42 9.9 0.0 2.6 2 0 0 2 2 2 2 Lipopolysaccharide kinase (Kdo/WaaP) family EGF_2 PF07974.13 ELR16290.1 - 7.4e-05 23.0 10.7 0.00014 22.1 10.7 1.5 1 0 0 1 1 1 1 EGF-like domain RIO1 PF01163.22 ELR16290.1 - 0.00033 20.3 1.4 0.6 9.7 0.1 2.4 2 0 0 2 2 2 2 RIO1 family Haspin_kinase PF12330.8 ELR16290.1 - 0.0004 19.5 0.1 0.035 13.1 0.0 2.2 2 0 0 2 2 2 1 Haspin like kinase domain Kinase-like PF14531.6 ELR16290.1 - 0.004 16.5 0.0 0.33 10.2 0.0 2.3 2 0 0 2 2 2 1 Kinase-like FTA2 PF13095.6 ELR16290.1 - 0.0041 16.8 0.2 0.089 12.4 0.0 2.7 2 1 0 3 3 3 1 Kinetochore Sim4 complex subunit FTA2 EGF_Tenascin PF18720.1 ELR16290.1 - 0.025 14.6 7.2 0.057 13.5 7.2 1.6 1 0 0 1 1 1 0 Tenascin EGF domain I-EGF_1 PF18372.1 ELR16290.1 - 0.075 13.1 2.6 0.15 12.1 2.6 1.5 1 0 0 1 1 1 0 Integrin beta epidermal growth factor like domain 1 TMEM154 PF15102.6 ELR16290.1 - 0.085 12.8 0.0 0.18 11.7 0.0 1.4 1 0 0 1 1 1 0 TMEM154 protein family Seadorna_VP7 PF07387.11 ELR16290.1 - 0.18 10.8 0.1 0.59 9.1 0.0 1.7 2 0 0 2 2 2 0 Seadornavirus VP7 EGF PF00008.27 ELR16290.1 - 0.27 11.6 3.4 0.55 10.6 3.4 1.5 1 0 0 1 1 1 0 EGF-like domain Myb_DNA-binding PF00249.31 ELR16291.1 - 0.0002 21.4 0.2 0.0002 21.4 0.2 2.4 2 0 0 2 2 2 1 Myb-like DNA-binding domain ELM2 PF01448.24 ELR16291.1 - 0.011 16.5 0.7 0.011 16.5 0.7 4.3 3 2 0 3 3 3 0 ELM2 domain Myb_DNA-bind_6 PF13921.6 ELR16291.1 - 0.036 14.3 0.7 0.13 12.5 0.3 2.2 2 0 0 2 2 2 0 Myb-like DNA-binding domain Cauli_AT PF03233.13 ELR16293.1 - 5.2 7.0 7.6 1 9.3 1.5 2.2 2 0 0 2 2 2 0 Aphid transmission protein Herpes_UL6 PF01763.16 ELR16293.1 - 7.8 4.9 9.5 0.12 10.9 1.4 1.8 2 0 0 2 2 2 0 Herpesvirus UL6 like TPR_1 PF00515.28 ELR16294.1 - 3.5e-13 48.7 10.5 7.3e-05 22.4 1.0 3.7 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.17 ELR16294.1 - 1.2e-12 46.9 11.0 0.00018 21.4 0.8 3.7 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_8 PF13181.6 ELR16294.1 - 1.6e-09 37.2 2.4 0.0064 16.6 0.0 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.6 ELR16294.1 - 3.5e-08 33.6 8.0 2.1e-06 27.9 5.0 2.6 1 1 0 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.6 ELR16294.1 - 1.4e-07 31.7 7.8 0.00072 20.2 2.6 3.2 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_6 PF13174.6 ELR16294.1 - 1.6e-07 31.5 4.4 0.00054 20.4 0.1 4.1 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_11 PF13414.6 ELR16294.1 - 4.9e-06 26.1 7.7 6.7e-05 22.5 1.6 3.0 3 1 0 3 3 3 2 TPR repeat TPR_16 PF13432.6 ELR16294.1 - 1.9e-05 25.2 9.7 0.12 13.1 2.3 3.1 2 1 0 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.6 ELR16294.1 - 4.6e-05 23.8 5.0 0.00013 22.4 4.8 1.8 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_7 PF13176.6 ELR16294.1 - 9.5e-05 22.2 6.5 0.075 13.1 1.5 3.8 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_17 PF13431.6 ELR16294.1 - 0.00015 21.9 3.2 0.039 14.3 0.1 2.9 3 0 0 3 3 3 2 Tetratricopeptide repeat BTAD PF03704.17 ELR16294.1 - 0.00026 21.4 5.7 0.00037 20.9 5.7 1.3 1 0 0 1 1 1 1 Bacterial transcriptional activator domain Fis1_TPR_C PF14853.6 ELR16294.1 - 0.0046 17.0 6.2 0.36 10.9 0.3 3.2 2 1 1 3 3 3 1 Fis1 C-terminal tetratricopeptide repeat ANAPC3 PF12895.7 ELR16294.1 - 0.014 15.6 7.0 0.051 13.8 6.8 2.0 1 1 1 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 TOM20_plant PF06552.12 ELR16294.1 - 0.062 13.0 0.1 0.14 11.9 0.1 1.6 1 1 0 1 1 1 0 Plant specific mitochondrial import receptor subunit TOM20 HHH_8 PF14716.6 ELR16294.1 - 0.13 12.7 3.8 0.14 12.5 0.4 2.4 3 0 0 3 3 2 0 Helix-hairpin-helix domain T3SS_ExsE PF18286.1 ELR16294.1 - 0.13 12.2 0.1 0.58 10.1 0.0 2.1 2 0 0 2 2 2 0 Type III secretion system ExsE DUF3856 PF12968.7 ELR16294.1 - 0.15 12.1 1.9 1.8 8.6 1.6 2.5 1 1 1 2 2 2 0 Domain of Unknown Function (DUF3856) TPR_10 PF13374.6 ELR16294.1 - 0.42 10.6 10.1 3.1 7.8 0.1 3.8 3 2 1 4 4 4 0 Tetratricopeptide repeat TPR_4 PF07721.14 ELR16294.1 - 0.57 11.0 4.4 7.2 7.6 1.4 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat SAP PF02037.27 ELR16295.1 - 9.9e-12 44.3 0.0 1.9e-11 43.4 0.0 1.5 1 0 0 1 1 1 1 SAP domain SMI1_KNR4 PF09346.10 ELR16295.1 - 7.6e-09 36.1 3.2 8.1e-07 29.5 0.0 2.3 2 0 0 2 2 2 1 SMI1 / KNR4 family (SUKH-1) DUF3801 PF12687.7 ELR16295.1 - 0.002 18.2 2.6 0.0028 17.7 2.6 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3801) BUD22 PF09073.10 ELR16295.1 - 0.0034 16.8 6.5 0.0034 16.8 6.5 1.1 1 0 0 1 1 1 1 BUD22 DNA_pol_phi PF04931.13 ELR16295.1 - 0.004 15.3 16.9 0.005 15.0 16.9 1.1 1 0 0 1 1 1 1 DNA polymerase phi DUF4518 PF15008.6 ELR16295.1 - 0.0063 15.7 0.2 0.0088 15.3 0.2 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4518) DUF2151 PF10221.9 ELR16295.1 - 0.017 13.8 1.1 0.021 13.5 1.1 1.0 1 0 0 1 1 1 0 Cell cycle and development regulator NPR3 PF03666.13 ELR16295.1 - 0.086 11.6 3.3 0.11 11.3 3.3 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Cwf_Cwc_15 PF04889.12 ELR16295.1 - 0.088 12.5 12.9 0.13 12.0 12.9 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Tim54 PF11711.8 ELR16295.1 - 0.11 11.3 5.9 0.14 10.9 5.9 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 GET2 PF08690.10 ELR16295.1 - 0.17 11.5 3.0 0.2 11.3 3.0 1.2 1 0 0 1 1 1 0 GET complex subunit GET2 Presenilin PF01080.17 ELR16295.1 - 0.2 10.4 2.4 0.22 10.3 2.4 1.1 1 0 0 1 1 1 0 Presenilin DUF913 PF06025.12 ELR16295.1 - 0.24 10.3 1.4 0.29 10.1 1.4 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Zip PF02535.22 ELR16295.1 - 0.24 10.6 3.0 0.25 10.5 3.0 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter SAPS PF04499.15 ELR16295.1 - 0.25 10.1 4.6 0.33 9.7 4.6 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Pox_Ag35 PF03286.14 ELR16295.1 - 0.33 10.7 6.5 0.54 10.0 6.5 1.4 1 0 0 1 1 1 0 Pox virus Ag35 surface protein Nop14 PF04147.12 ELR16295.1 - 0.41 8.8 14.4 0.51 8.5 14.4 1.1 1 0 0 1 1 1 0 Nop14-like family SDA1 PF05285.12 ELR16295.1 - 0.49 9.8 19.8 0.74 9.2 19.8 1.2 1 0 0 1 1 1 0 SDA1 ORC6 PF05460.13 ELR16295.1 - 0.99 8.6 7.9 1.4 8.1 7.9 1.2 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) DUF4820 PF16091.5 ELR16295.1 - 1.8 7.9 4.4 2.5 7.4 4.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) PPP4R2 PF09184.11 ELR16295.1 - 1.9 8.0 16.8 3.1 7.3 16.8 1.3 1 0 0 1 1 1 0 PPP4R2 NOA36 PF06524.12 ELR16295.1 - 2 7.7 13.7 3.1 7.0 13.7 1.3 1 0 0 1 1 1 0 NOA36 protein SLC12 PF03522.15 ELR16295.1 - 6.1 5.8 6.1 10 5.0 5.7 1.5 1 1 1 2 2 2 0 Solute carrier family 12 PGM1_C PF18105.1 ELR16296.1 - 1.6e-05 24.4 0.0 3.5e-05 23.2 0.0 1.6 1 0 0 1 1 1 1 PGM1 C-terminal domain RhoGEF PF00621.20 ELR16297.1 - 4e-35 121.7 3.1 7e-35 120.9 3.1 1.4 1 0 0 1 1 1 1 RhoGEF domain PH PF00169.29 ELR16297.1 - 1.1e-06 29.1 0.0 2.4e-06 28.0 0.0 1.6 1 0 0 1 1 1 1 PH domain IQ_SEC7_PH PF16453.5 ELR16297.1 - 7.2e-05 22.8 0.0 0.00013 22.0 0.0 1.4 1 0 0 1 1 1 1 PH domain PH_16 PF17838.1 ELR16297.1 - 0.076 12.9 1.5 0.95 9.3 0.9 2.5 2 1 0 2 2 2 0 PH domain DUF3168 PF11367.8 ELR16297.1 - 0.098 12.8 0.0 0.23 11.7 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3168) PH_10 PF15411.6 ELR16297.1 - 0.13 12.5 0.0 0.3 11.4 0.0 1.6 1 0 0 1 1 1 0 Pleckstrin homology domain Choline_transpo PF04515.12 ELR16298.1 - 5.3e-77 259.2 32.5 5.3e-77 259.2 32.5 2.3 1 1 1 2 2 2 1 Plasma-membrane choline transporter Pex14_N PF04695.13 ELR16298.1 - 0.079 13.6 0.0 0.28 11.8 0.0 1.9 1 1 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Lactamase_B_2 PF12706.7 ELR16299.1 - 1.4e-36 125.9 0.0 3.3e-36 124.7 0.0 1.6 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 ELR16299.1 - 1.2e-07 31.7 0.0 2.3e-07 30.9 0.0 1.4 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B PF00753.27 ELR16299.1 - 0.03 14.3 0.1 0.18 11.8 0.0 2.2 2 0 0 2 2 2 0 Metallo-beta-lactamase superfamily Cytokin_check_N PF10407.9 ELR16300.1 - 0.0014 18.5 0.1 0.0028 17.6 0.1 1.4 1 0 0 1 1 1 1 Cdc14 phosphatase binding protein N-terminus WD40 PF00400.32 ELR16301.1 - 1.8e-38 129.8 13.9 7.3e-09 36.1 0.0 6.2 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ELR16301.1 - 4.9e-12 46.0 0.4 9.5e-05 22.6 0.0 4.5 2 2 2 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 ELR16301.1 - 0.00016 21.6 0.9 2.5 7.9 0.0 3.5 2 1 1 4 4 4 3 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 ELR16301.1 - 0.0012 17.7 5.7 4.2 5.9 0.0 4.5 3 1 2 5 5 5 2 Nucleoporin Nup120/160 Hira PF07569.11 ELR16301.1 - 0.0081 15.9 0.7 1 9.0 0.1 2.4 1 1 1 2 2 2 2 TUP1-like enhancer of split Ge1_WD40 PF16529.5 ELR16301.1 - 0.0096 14.9 1.4 4.5 6.1 0.0 3.6 2 2 2 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Nucleoporin_N PF08801.11 ELR16301.1 - 0.011 14.5 0.1 0.061 12.1 0.0 2.3 1 1 1 2 2 2 0 Nup133 N terminal like Cytochrom_D1 PF02239.16 ELR16301.1 - 0.046 12.2 0.2 1.1 7.7 0.1 2.6 2 1 1 3 3 3 0 Cytochrome D1 heme domain PD40 PF07676.12 ELR16301.1 - 0.11 12.4 0.0 3.9 7.5 0.0 3.0 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat DUF229 PF02995.17 ELR16302.1 - 1.1e-44 152.9 0.1 3.2e-44 151.4 0.1 1.7 1 1 0 1 1 1 1 Protein of unknown function (DUF229) NEL PF14496.6 ELR16302.1 - 0.0027 17.2 1.1 0.0064 15.9 1.1 1.6 1 0 0 1 1 1 1 C-terminal novel E3 ligase, LRR-interacting Sulfatase PF00884.23 ELR16302.1 - 0.013 14.9 1.0 0.11 11.9 1.1 2.1 1 1 0 1 1 1 0 Sulfatase F-box-like PF12937.7 ELR16303.1 - 0.089 12.7 0.3 0.089 12.7 0.3 2.0 2 0 0 2 2 2 0 F-box-like Amdo_NSP PF12475.8 ELR16303.1 - 0.32 11.1 1.2 8.3 6.6 0.3 3.1 4 0 0 4 4 4 0 Amdovirus non-structural protein Glyco_hydro_31 PF01055.26 ELR16305.1 - 1.6e-57 195.6 12.1 4.9e-57 194.1 12.1 1.6 1 1 0 1 1 1 1 Glycosyl hydrolases family 31 HLH PF00010.26 ELR16306.1 - 8.5e-13 48.1 0.3 1.4e-12 47.4 0.3 1.4 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain FH2 PF02181.23 ELR16306.1 - 0.036 13.2 0.0 0.056 12.6 0.0 1.2 1 0 0 1 1 1 0 Formin Homology 2 Domain bZIP_1 PF00170.21 ELR16306.1 - 0.041 14.0 1.5 0.08 13.0 0.0 2.0 2 0 0 2 2 2 0 bZIP transcription factor Shugoshin_N PF07558.11 ELR16306.1 - 0.056 13.3 0.1 0.1 12.5 0.1 1.3 1 0 0 1 1 1 0 Shugoshin N-terminal coiled-coil region TSC22 PF01166.18 ELR16306.1 - 0.096 13.0 0.0 0.18 12.1 0.0 1.5 1 0 0 1 1 1 0 TSC-22/dip/bun family Cep57_MT_bd PF06657.13 ELR16306.1 - 0.12 12.9 0.7 1.3 9.5 0.0 2.3 2 0 0 2 2 2 0 Centrosome microtubule-binding domain of Cep57 CCDC-167 PF15188.6 ELR16306.1 - 0.53 10.7 3.2 4.8 7.6 3.2 2.2 1 1 0 1 1 1 0 Coiled-coil domain-containing protein 167 RasGEF PF00617.19 ELR16308.1 - 1.4e-42 145.9 2.9 3.7e-42 144.5 1.4 2.1 2 0 0 2 2 2 1 RasGEF domain TFIIF_alpha PF05793.12 ELR16308.1 - 0.66 8.5 37.2 1.1 7.8 37.2 1.3 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) 3Beta_HSD PF01073.19 ELR16309.1 - 3.9e-51 173.7 0.0 5.5e-51 173.2 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 ELR16309.1 - 2.1e-28 99.4 0.0 6.7e-28 97.8 0.0 1.7 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 ELR16309.1 - 5.2e-16 59.0 0.0 2.8e-13 50.0 0.0 2.5 2 1 0 2 2 2 2 GDP-mannose 4,6 dehydratase NAD_binding_4 PF07993.12 ELR16309.1 - 1.8e-13 50.2 0.0 1.2e-09 37.7 0.0 2.1 1 1 1 2 2 2 2 Male sterility protein NAD_binding_10 PF13460.6 ELR16309.1 - 1.2e-12 48.1 0.0 2e-12 47.4 0.0 1.4 1 0 0 1 1 1 1 NAD(P)H-binding Polysacc_synt_2 PF02719.15 ELR16309.1 - 2.4e-09 36.8 0.0 3.6e-08 32.9 0.0 2.2 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein RmlD_sub_bind PF04321.17 ELR16309.1 - 9.6e-09 34.7 0.0 1.5e-08 34.1 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain NmrA PF05368.13 ELR16309.1 - 0.00023 20.8 0.0 0.00037 20.1 0.0 1.3 1 0 0 1 1 1 1 NmrA-like family Sacchrp_dh_NADP PF03435.18 ELR16309.1 - 0.00034 20.9 0.1 0.028 14.7 0.1 2.3 1 1 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain KR PF08659.10 ELR16309.1 - 0.0014 18.6 0.3 0.0094 15.9 0.3 2.0 1 1 0 1 1 1 1 KR domain DUF563 PF04577.14 ELR16310.1 - 4.4e-29 102.1 0.0 6.2e-29 101.6 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF563) MetOD1 PF18546.1 ELR16310.1 - 0.11 12.5 0.0 1 9.3 0.0 2.3 2 0 0 2 2 2 0 Metanogen output domain 1 2CSK_N PF08521.10 ELR16310.1 - 0.15 12.2 0.2 0.26 11.4 0.2 1.4 1 0 0 1 1 1 0 Two-component sensor kinase N-terminal TFIIA_gamma_N PF02268.16 ELR16311.1 - 1.1e-20 73.3 0.1 1.5e-20 72.9 0.1 1.2 1 0 0 1 1 1 1 Transcription initiation factor IIA, gamma subunit, helical domain TFIIA_gamma_C PF02751.14 ELR16311.1 - 6.6e-20 71.0 0.9 9.7e-20 70.5 0.9 1.3 1 0 0 1 1 1 1 Transcription initiation factor IIA, gamma subunit BAR_3 PF16746.5 ELR16312.1 - 1.1e-06 28.5 10.6 1.8e-06 27.9 10.6 1.2 1 0 0 1 1 1 1 BAR domain of APPL family DUF4288 PF14119.6 ELR16312.1 - 0.015 15.7 2.1 0.064 13.7 1.3 2.4 2 1 1 3 3 3 0 Domain of unknown function (DUF4288) BAR_2 PF10455.9 ELR16312.1 - 0.023 13.8 10.5 0.039 13.1 10.5 1.3 1 0 0 1 1 1 0 Bin/amphiphysin/Rvs domain for vesicular trafficking Endotoxin_C2 PF18449.1 ELR16312.1 - 0.1 13.0 0.8 3.7 8.0 0.1 2.9 2 0 0 2 2 2 0 Delta endotoxin AAA_27 PF13514.6 ELR16312.1 - 0.19 11.3 4.7 0.11 12.1 0.5 2.3 2 0 0 2 2 2 0 AAA domain IL7 PF01415.16 ELR16312.1 - 0.45 10.5 2.6 0.95 9.5 2.6 1.4 1 0 0 1 1 1 0 Interleukin 7/9 family KxDL PF10241.9 ELR16312.1 - 0.46 10.8 5.0 4.2 7.7 0.6 3.0 2 1 1 3 3 3 0 Uncharacterized conserved protein Exo_endo_phos PF03372.23 ELR16313.1 - 0.0023 17.5 0.1 0.004 16.7 0.1 1.4 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family AAA_11 PF13086.6 ELR16313.1 - 0.013 15.3 3.1 0.016 15.0 3.1 1.3 1 0 0 1 1 1 0 AAA domain DUF4746 PF15928.5 ELR16313.1 - 0.016 14.6 3.4 0.023 14.2 3.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Borrelia_P83 PF05262.11 ELR16313.1 - 0.017 13.7 8.0 0.021 13.3 8.0 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein Atg14 PF10186.9 ELR16313.1 - 0.044 12.9 7.2 0.08 12.0 7.2 1.4 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Tau95 PF09734.9 ELR16313.1 - 0.053 14.3 0.6 0.1 13.4 0.6 1.4 1 0 0 1 1 1 0 RNA polymerase III transcription factor (TF)IIIC subunit HTH domain DUF913 PF06025.12 ELR16313.1 - 0.067 12.2 1.0 0.096 11.7 1.0 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) PA26 PF04636.13 ELR16313.1 - 0.081 11.8 0.9 0.11 11.4 0.9 1.1 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) TMPIT PF07851.13 ELR16313.1 - 0.17 11.1 9.9 0.24 10.6 9.9 1.1 1 0 0 1 1 1 0 TMPIT-like protein DUF4407 PF14362.6 ELR16313.1 - 0.41 10.0 5.1 0.79 9.0 5.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) GAS PF13851.6 ELR16313.1 - 0.48 9.8 25.6 0.78 9.1 25.6 1.2 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding DUF1943 PF09172.11 ELR16313.1 - 0.66 9.2 5.8 0.99 8.6 5.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1943) Allexi_40kDa PF05549.11 ELR16313.1 - 0.68 9.4 3.6 1.6 8.2 2.8 1.8 2 0 0 2 2 2 0 Allexivirus 40kDa protein Tho2 PF11262.8 ELR16313.1 - 0.73 9.0 10.3 1.1 8.4 10.3 1.2 1 0 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 DUF4446 PF14584.6 ELR16313.1 - 1.6 8.7 6.2 3.4 7.6 6.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4446) AAA_23 PF13476.6 ELR16313.1 - 2.3 8.7 15.3 4.5 7.7 15.3 1.4 1 0 0 1 1 1 0 AAA domain MCU PF04678.13 ELR16313.1 - 2.4 8.3 6.6 4.2 7.4 6.6 1.3 1 0 0 1 1 1 0 Mitochondrial calcium uniporter DDRGK PF09756.9 ELR16313.1 - 3 7.4 23.9 4.7 6.7 23.9 1.2 1 0 0 1 1 1 0 DDRGK domain Presenilin PF01080.17 ELR16313.1 - 3.2 6.4 4.6 4.6 5.9 4.6 1.1 1 0 0 1 1 1 0 Presenilin USP8_interact PF08941.10 ELR16313.1 - 3.2 7.5 5.7 5.8 6.7 5.7 1.4 1 0 0 1 1 1 0 USP8 interacting WDCP PF15390.6 ELR16313.1 - 3.4 5.9 5.6 4.8 5.4 5.6 1.1 1 0 0 1 1 1 0 WD repeat and coiled-coil-containing protein family RR_TM4-6 PF06459.12 ELR16313.1 - 4.9 6.9 12.1 7.3 6.3 12.1 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 V_ATPase_I PF01496.19 ELR16313.1 - 5.3 4.8 9.3 7.4 4.4 9.3 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family FemAB PF02388.16 ELR16313.1 - 7.3 5.4 11.3 10 4.8 11.3 1.1 1 0 0 1 1 1 0 FemAB family HlyIII PF03006.20 ELR16314.1 - 8.3e-24 84.5 18.8 8.1e-21 74.8 18.8 2.3 1 1 0 1 1 1 1 Haemolysin-III related RhoGAP PF00620.27 ELR16315.1 - 1.1e-18 67.5 0.0 2.2e-18 66.5 0.0 1.4 1 0 0 1 1 1 1 RhoGAP domain FERM_f0 PF16511.5 ELR16315.1 - 3.6e-08 33.6 0.0 6.1e-08 32.9 0.0 1.4 1 0 0 1 1 1 1 N-terminal or F0 domain of Talin-head FERM Adap_comp_sub PF00928.21 ELR16316.1 - 1.2e-11 44.6 0.0 1.8e-11 43.9 0.0 1.2 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 ELR16316.1 - 0.0013 18.7 0.1 0.0023 17.9 0.1 1.5 1 0 0 1 1 1 1 Clathrin adaptor complex small chain Raftlin PF15250.6 ELR16316.1 - 0.019 13.7 0.0 0.027 13.2 0.0 1.1 1 0 0 1 1 1 0 Raftlin Hint PF01079.20 ELR16316.1 - 0.078 12.5 0.7 8.4 5.8 0.1 2.2 2 0 0 2 2 2 0 Hint module UCH PF00443.29 ELR16317.1 - 1.4e-52 178.7 0.0 1.9e-52 178.3 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 ELR16317.1 - 1.2e-19 71.1 0.4 4.1e-19 69.3 0.4 1.8 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP PF02148.19 ELR16317.1 - 8.1e-13 48.5 6.0 8.1e-13 48.5 6.0 2.6 2 0 0 2 2 2 1 Zn-finger in ubiquitin-hydrolases and other protein Peptidase_C98 PF15499.6 ELR16317.1 - 0.0044 16.5 2.0 0.78 9.2 0.0 3.3 3 1 0 3 3 3 1 Ubiquitin-specific peptidase-like, SUMO isopeptidase Cullin PF00888.22 ELR16318.1 - 1.9e-27 96.2 0.0 2.5e-27 95.8 0.0 1.2 1 0 0 1 1 1 1 Cullin family HbrB PF08539.11 ELR16318.1 - 0.049 13.6 0.0 0.087 12.8 0.0 1.4 1 1 0 1 1 1 0 HbrB-like Nckap1 PF09735.9 ELR16319.1 - 6.1e-296 984.9 6.7 6.9e-296 984.7 6.7 1.0 1 0 0 1 1 1 1 Membrane-associated apoptosis protein Dynamin_N PF00350.23 ELR16321.1 - 5.5e-21 75.3 0.0 1.4e-20 74.1 0.0 1.7 1 1 0 1 1 1 1 Dynamin family Dynamin_M PF01031.20 ELR16321.1 - 4.1e-07 29.5 0.0 7e-06 25.5 0.0 2.4 3 0 0 3 3 3 1 Dynamin central region MMR_HSR1 PF01926.23 ELR16321.1 - 9.7e-06 25.6 0.0 5e-05 23.4 0.0 2.2 2 1 0 2 2 2 1 50S ribosome-binding GTPase AAA_16 PF13191.6 ELR16321.1 - 0.0024 18.3 2.1 0.013 15.9 0.0 2.8 2 2 0 2 2 2 1 AAA ATPase domain FeoB_N PF02421.18 ELR16321.1 - 0.011 15.3 0.0 0.84 9.2 0.0 2.6 2 0 0 2 2 2 0 Ferrous iron transport protein B Roc PF08477.13 ELR16321.1 - 0.013 15.8 0.1 0.26 11.5 0.0 2.7 3 0 0 3 3 3 0 Ras of Complex, Roc, domain of DAPkinase NACHT PF05729.12 ELR16321.1 - 0.1 12.5 0.0 12 5.7 0.1 2.6 2 0 0 2 2 2 0 NACHT domain Cohesin_load PF10345.9 ELR16322.1 - 0.00011 20.8 4.3 0.00024 19.7 4.2 1.6 1 1 0 1 1 1 1 Cohesin loading factor DnaJ PF00226.31 ELR16323.1 - 4.5e-10 39.5 0.1 7e-10 38.9 0.1 1.3 1 0 0 1 1 1 1 DnaJ domain Annexin PF00191.20 ELR16323.1 - 0.17 12.0 0.0 0.44 10.7 0.0 1.7 1 0 0 1 1 1 0 Annexin Cofilin_ADF PF00241.20 ELR16324.1 - 1.7e-10 40.8 0.0 2.4e-10 40.3 0.0 1.2 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein SpoU_methylase PF00588.19 ELR16325.1 - 2.6e-25 89.2 0.1 2.1e-23 83.1 0.1 2.0 1 1 0 1 1 1 1 SpoU rRNA Methylase family SPOUT_MTase_2 PF14419.6 ELR16325.1 - 0.095 12.1 0.0 0.13 11.6 0.0 1.2 1 0 0 1 1 1 0 AF2226-like SPOUT RNA Methylase fused to THUMP bZIP_1 PF00170.21 ELR16326.1 - 1.4e-12 47.5 7.4 1.4e-12 47.5 7.4 2.4 3 0 0 3 3 3 1 bZIP transcription factor bZIP_2 PF07716.15 ELR16326.1 - 1.4e-10 41.1 5.4 1.4e-10 41.1 5.4 2.1 2 0 0 2 2 2 1 Basic region leucine zipper bZIP_Maf PF03131.17 ELR16326.1 - 4.7e-06 27.0 7.5 4.7e-06 27.0 7.5 2.2 2 0 0 2 2 2 1 bZIP Maf transcription factor DUF812 PF05667.11 ELR16326.1 - 0.0052 15.7 3.0 0.0065 15.4 3.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF812) TSC22 PF01166.18 ELR16326.1 - 0.05 13.9 2.9 0.18 12.1 1.6 2.5 1 1 1 2 2 2 0 TSC-22/dip/bun family Phlebovirus_NSM PF07246.11 ELR16326.1 - 0.061 12.7 1.0 0.08 12.3 1.0 1.1 1 0 0 1 1 1 0 Phlebovirus nonstructural protein NS-M Ribosomal_60s PF00428.19 ELR16326.1 - 0.062 13.9 2.5 0.12 13.0 2.5 1.5 1 0 0 1 1 1 0 60s Acidic ribosomal protein DivIC PF04977.15 ELR16326.1 - 0.08 12.7 7.5 0.066 13.0 2.7 2.3 2 0 0 2 2 2 0 Septum formation initiator CASP_C PF08172.12 ELR16326.1 - 0.62 9.4 8.4 1.1 8.5 8.4 1.4 1 1 0 1 1 1 0 CASP C terminal DUF4407 PF14362.6 ELR16326.1 - 2.9 7.2 6.6 4.1 6.7 6.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) E1-E2_ATPase PF00122.20 ELR16328.1 - 3.1e-19 69.2 0.1 6.1e-19 68.2 0.1 1.5 1 0 0 1 1 1 1 E1-E2 ATPase Cation_ATPase_N PF00690.26 ELR16328.1 - 1.1e-05 25.1 0.0 2.7e-05 23.8 0.0 1.7 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase PF00702.26 ELR16328.1 - 3.8e-05 24.1 1.9 0.37 11.1 0.0 3.3 2 1 1 3 3 3 2 haloacid dehalogenase-like hydrolase DUF1581 PF07619.11 ELR16328.1 - 0.065 13.4 0.0 0.14 12.3 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1581) DUF3915 PF13054.6 ELR16328.1 - 3.6 7.6 8.4 13 5.8 8.4 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) Macoilin PF09726.9 ELR16328.1 - 4.1 5.8 12.6 5.6 5.4 12.6 1.1 1 0 0 1 1 1 0 Macoilin family APH PF01636.23 ELR16329.1 - 1.9e-13 50.9 2.0 1.9e-13 50.9 2.0 1.9 2 0 0 2 2 2 1 Phosphotransferase enzyme family RIO1 PF01163.22 ELR16329.1 - 0.049 13.2 0.0 0.12 12.0 0.0 1.5 2 0 0 2 2 2 0 RIO1 family PaaX_C PF08223.11 ELR16329.1 - 0.13 12.6 0.6 0.37 11.1 0.6 1.7 1 0 0 1 1 1 0 PaaX-like protein C-terminal domain PH PF00169.29 ELR16330.1 - 2.4e-08 34.4 0.0 3.2e-07 30.8 0.0 2.4 1 1 0 1 1 1 1 PH domain PH_3 PF14593.6 ELR16330.1 - 1.8e-06 28.0 0.0 0.0027 17.8 0.0 2.4 2 0 0 2 2 2 2 PH domain TPR_17 PF13431.6 ELR16330.1 - 0.00011 22.3 0.2 0.97 10.0 0.0 2.8 2 0 0 2 2 2 2 Tetratricopeptide repeat PH_11 PF15413.6 ELR16330.1 - 0.00082 19.8 0.0 0.002 18.5 0.0 1.8 1 0 0 1 1 1 1 Pleckstrin homology domain Myosin_TH1 PF06017.13 ELR16330.1 - 0.017 14.8 0.0 0.031 13.9 0.0 1.3 1 0 0 1 1 1 0 Unconventional myosin tail, actin- and lipid-binding PH_8 PF15409.6 ELR16330.1 - 0.018 15.3 0.0 0.052 13.8 0.0 1.7 2 0 0 2 2 2 0 Pleckstrin homology domain TPR_11 PF13414.6 ELR16330.1 - 0.049 13.3 5.5 1.2 8.9 0.8 3.5 3 0 0 3 3 3 0 TPR repeat TOM20_plant PF06552.12 ELR16330.1 - 0.052 13.3 1.3 0.097 12.4 0.3 2.0 2 1 0 2 2 2 0 Plant specific mitochondrial import receptor subunit TOM20 TPR_16 PF13432.6 ELR16330.1 - 0.38 11.4 4.3 16 6.3 0.1 3.6 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_10 PF13374.6 ELR16330.1 - 0.47 10.4 3.1 12 5.9 0.0 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_14 PF13428.6 ELR16330.1 - 0.82 10.7 4.6 33 5.7 0.4 4.4 3 2 1 4 4 4 0 Tetratricopeptide repeat TPR_2 PF07719.17 ELR16330.1 - 3.6 7.9 17.0 0.42 10.8 1.0 5.7 7 1 0 7 7 7 0 Tetratricopeptide repeat Ribosomal_L14 PF00238.19 ELR16331.1 - 2e-35 121.5 0.1 2.4e-35 121.3 0.1 1.0 1 0 0 1 1 1 1 Ribosomal protein L14p/L23e SET PF00856.28 ELR16332.1 - 1.2e-06 29.1 0.3 1.8e-05 25.2 0.3 2.1 1 1 0 1 1 1 1 SET domain DDE_Tnp_2 PF04693.12 ELR16332.1 - 0.1 11.8 0.0 0.13 11.4 0.0 1.1 1 0 0 1 1 1 0 Archaeal putative transposase ISC1217 PEMT PF04191.13 ELR16335.1 - 3.8e-53 178.4 14.6 1.7e-32 112.0 2.2 2.9 2 0 0 2 2 2 2 Phospholipid methyltransferase HAP1_N PF04849.13 ELR16335.1 - 0.044 13.0 1.3 0.065 12.4 1.3 1.1 1 0 0 1 1 1 0 HAP1 N-terminal conserved region Ndc80_HEC PF03801.13 ELR16336.1 - 7.4e-36 123.1 0.0 2.7e-35 121.2 0.0 1.9 1 0 0 1 1 1 1 HEC/Ndc80p family FUSC PF04632.12 ELR16336.1 - 0.0022 16.7 0.6 0.0022 16.7 0.6 2.1 2 0 0 2 2 2 1 Fusaric acid resistance protein family Mce4_CUP1 PF11887.8 ELR16336.1 - 0.008 15.7 1.3 0.008 15.7 1.3 1.9 2 0 0 2 2 2 1 Cholesterol uptake porter CUP1 of Mce4, putative DUF1664 PF07889.12 ELR16336.1 - 0.12 12.4 24.0 0.64 10.1 3.4 4.4 2 2 3 5 5 5 0 Protein of unknown function (DUF1664) CdvA PF18822.1 ELR16336.1 - 0.31 10.9 26.3 1.1 9.1 0.6 4.9 2 2 3 5 5 5 0 CdvA-like coiled-coil domain TraF_2 PF13729.6 ELR16336.1 - 1.2 8.5 8.6 1.1 8.6 1.8 3.3 3 1 0 3 3 3 0 F plasmid transfer operon, TraF, protein Filament PF00038.21 ELR16336.1 - 1.7 8.1 33.7 0.38 10.3 11.2 2.8 2 1 1 3 3 3 0 Intermediate filament protein AROS PF15684.5 ELR16336.1 - 2.7 8.6 9.3 0.7 10.5 2.0 2.4 2 0 0 2 2 2 0 Active regulator of SIRT1, or 40S ribosomal protein S19-binding 1 GARP PF16731.5 ELR16336.1 - 3.4 7.3 21.2 1.2 8.8 11.1 3.1 3 0 0 3 3 3 0 Glutamic acid/alanine-rich protein of Trypanosoma JIP_LZII PF16471.5 ELR16336.1 - 6.8 6.9 21.7 3.4 7.9 0.4 4.6 4 1 0 4 4 4 0 JNK-interacting protein leucine zipper II PH_11 PF15413.6 ELR16336.1 - 9.5 6.7 7.4 24 5.4 0.4 3.1 3 1 0 3 3 3 0 Pleckstrin homology domain Rap_GAP PF02145.15 ELR16337.1 - 6.1e-57 192.2 0.0 1.2e-56 191.2 0.0 1.5 1 0 0 1 1 1 1 Rap/ran-GAP Menin PF05053.13 ELR16337.1 - 2.2 6.6 6.8 3.8 5.8 6.8 1.3 1 0 0 1 1 1 0 Menin TAFII28 PF04719.14 ELR16338.1 - 3.6e-36 123.1 0.1 5.8e-36 122.5 0.1 1.3 1 0 0 1 1 1 1 hTAFII28-like protein conserved region SDA1 PF05285.12 ELR16338.1 - 0.00027 20.5 13.9 0.00028 20.4 13.9 1.0 1 0 0 1 1 1 1 SDA1 CDC45 PF02724.14 ELR16338.1 - 0.015 13.6 11.4 0.015 13.7 11.4 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF913 PF06025.12 ELR16338.1 - 0.033 13.2 3.5 0.05 12.6 3.5 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) RRN3 PF05327.11 ELR16338.1 - 0.13 10.8 6.6 0.15 10.5 6.6 1.2 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 GET2 PF08690.10 ELR16338.1 - 0.55 9.9 4.3 0.69 9.5 4.3 1.1 1 0 0 1 1 1 0 GET complex subunit GET2 RR_TM4-6 PF06459.12 ELR16338.1 - 1.9 8.2 13.5 2.6 7.8 13.5 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Nop14 PF04147.12 ELR16338.1 - 3 5.9 21.1 3.4 5.8 21.1 1.1 1 0 0 1 1 1 0 Nop14-like family DUF1682 PF07946.14 ELR16338.1 - 3.9 6.6 11.1 6.9 5.8 11.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) Cytochrom_B558a PF05038.13 ELR16339.1 - 0.016 14.8 1.6 0.04 13.5 0.2 1.9 2 0 0 2 2 2 0 Cytochrome Cytochrome b558 alpha-subunit PAS_9 PF13426.7 ELR16340.1 - 1.1e-36 125.2 0.0 1.7e-13 50.7 0.0 3.6 3 0 0 3 3 3 3 PAS domain PAS PF00989.25 ELR16340.1 - 1.5e-36 124.8 0.0 1.1e-10 41.5 0.0 3.7 4 0 0 4 4 4 3 PAS fold SAM_1 PF00536.30 ELR16340.1 - 1.4e-17 63.9 0.1 2.5e-17 63.1 0.1 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 ELR16340.1 - 8e-15 54.7 0.1 1.7e-14 53.7 0.1 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) PAS_4 PF08448.10 ELR16340.1 - 9.3e-15 54.8 0.0 0.00035 20.8 0.0 3.6 3 0 0 3 3 3 3 PAS fold PB1 PF00564.24 ELR16340.1 - 3e-11 43.1 0.1 5.3e-11 42.3 0.1 1.4 1 0 0 1 1 1 1 PB1 domain PAS_8 PF13188.7 ELR16340.1 - 4.7e-10 39.2 0.0 0.038 14.0 0.0 3.5 3 0 0 3 3 3 3 PAS domain PAS_3 PF08447.12 ELR16340.1 - 0.00014 22.1 0.0 0.13 12.6 0.0 3.1 3 0 0 3 3 3 2 PAS fold SAM_PNT PF02198.16 ELR16340.1 - 0.00062 19.7 0.0 0.0011 18.9 0.0 1.4 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain DUF4903 PF16246.5 ELR16340.1 - 0.028 14.1 0.1 0.69 9.5 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4903) Flavi_NS1 PF00948.21 ELR16340.1 - 0.046 12.6 0.0 4.9 5.9 0.0 2.2 1 1 0 2 2 2 0 Flavivirus non-structural Protein NS1 ADH_zinc_N_2 PF13602.6 ELR16341.1 - 3.7e-22 79.8 0.0 8.7e-22 78.6 0.0 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.26 ELR16341.1 - 2.6e-20 72.7 0.1 6e-20 71.5 0.0 1.7 2 1 0 2 2 2 1 Zinc-binding dehydrogenase ADH_N PF08240.12 ELR16341.1 - 0.11 12.4 5.3 0.092 12.6 1.6 2.7 2 1 1 3 3 3 0 Alcohol dehydrogenase GroES-like domain HECT PF00632.25 ELR16342.1 - 1.3e-89 300.7 0.0 1.8e-89 300.2 0.0 1.2 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) Ank_2 PF12796.7 ELR16342.1 - 1.7e-27 95.8 9.5 1.3e-11 44.9 1.2 4.9 2 1 3 5 5 5 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ELR16342.1 - 7e-19 68.0 11.3 7.3e-09 36.0 0.1 6.4 4 2 2 6 6 6 4 Ankyrin repeats (many copies) Ank PF00023.30 ELR16342.1 - 1.8e-17 62.9 5.0 6.2e-06 26.4 0.3 5.2 4 0 0 4 4 4 3 Ankyrin repeat Ank_3 PF13606.6 ELR16342.1 - 6.2e-15 53.8 4.8 0.00018 21.7 0.0 7.2 6 1 1 7 7 7 3 Ankyrin repeat Ank_5 PF13857.6 ELR16342.1 - 3.2e-14 52.8 4.5 5.9e-06 26.5 0.2 4.7 3 1 1 4 4 4 2 Ankyrin repeats (many copies) DUF4532 PF15046.6 ELR16343.1 - 0.098 11.8 0.1 0.15 11.3 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4532) YbjQ_1 PF01906.17 ELR16344.1 - 3.4e-25 88.7 0.5 4.2e-25 88.4 0.5 1.1 1 0 0 1 1 1 1 Putative heavy-metal-binding RcsF PF16358.5 ELR16344.1 - 0.081 13.0 1.1 0.43 10.7 0.3 2.1 1 1 1 2 2 2 0 RcsF lipoprotein DUF883 PF05957.13 ELR16345.1 - 0.017 15.7 3.8 0.43 11.2 1.0 2.2 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF883) Ras PF00071.22 ELR16346.1 - 4.6e-46 156.4 0.0 5.3e-46 156.2 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR16346.1 - 2.7e-15 56.6 0.0 4e-15 56.1 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR16346.1 - 5.4e-07 29.2 0.0 6.2e-07 29.0 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 ELR16346.1 - 7.3e-06 25.6 0.0 9.5e-06 25.3 0.0 1.1 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 ELR16346.1 - 0.018 14.4 0.0 0.07 12.5 0.0 1.8 1 1 0 1 1 1 0 Gtr1/RagA G protein conserved region PduV-EutP PF10662.9 ELR16346.1 - 0.078 12.7 0.0 0.11 12.2 0.0 1.3 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation Mon1 PF03164.14 ELR16346.1 - 0.081 12.0 0.0 2.7 7.0 0.0 2.0 2 0 0 2 2 2 0 Trafficking protein Mon1 Ribosomal_L24e PF01246.20 ELR16347.1 - 2.1e-12 47.1 1.6 2.1e-12 47.1 1.6 2.0 2 0 0 2 2 2 1 Ribosomal protein L24e C12orf66_like PF09404.10 ELR16348.1 - 3.7e-46 157.9 0.5 2.2e-33 115.8 0.0 2.0 1 1 1 2 2 2 2 KICSTOR complex C12orf66 like TPR_1 PF00515.28 ELR16348.1 - 0.33 10.9 2.3 0.62 10.0 0.6 2.4 3 0 0 3 3 3 0 Tetratricopeptide repeat Glyco_hydro_71 PF03659.14 ELR16349.1 - 9e-84 281.4 5.2 1.1e-83 281.1 5.2 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 71 G-patch PF01585.23 ELR16350.1 - 1.3e-16 60.2 1.5 2.2e-16 59.4 1.5 1.4 1 0 0 1 1 1 1 G-patch domain Surp PF01805.20 ELR16350.1 - 1.5e-14 53.7 0.0 3.6e-14 52.5 0.0 1.7 1 0 0 1 1 1 1 Surp module G-patch_2 PF12656.7 ELR16350.1 - 4.3e-06 26.7 0.2 8.9e-06 25.7 0.2 1.5 1 0 0 1 1 1 1 G-patch domain Btz PF09405.10 ELR16351.1 - 4.4e-06 27.0 7.4 4.4e-06 27.0 7.4 4.8 2 2 1 3 3 3 1 CASC3/Barentsz eIF4AIII binding TatD_DNase PF01026.21 ELR16352.1 - 6.4e-70 235.4 0.0 7.4e-70 235.2 0.0 1.0 1 0 0 1 1 1 1 TatD related DNase PNKP_ligase PF16542.5 ELR16352.1 - 0.039 13.4 0.6 0.26 10.7 0.1 2.2 3 0 0 3 3 3 0 PNKP adenylyltransferase domain, ligase domain Ras PF00071.22 ELR16353.1 - 8.8e-55 184.7 0.1 1e-54 184.5 0.1 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR16353.1 - 8.4e-24 84.1 0.0 1.2e-23 83.6 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR16353.1 - 3.1e-14 52.8 0.0 3.9e-14 52.5 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 ELR16353.1 - 0.00011 21.8 0.1 0.00031 20.3 0.0 1.6 1 1 0 2 2 2 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 ELR16353.1 - 0.00014 21.3 0.0 0.00046 19.6 0.0 1.7 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 ELR16353.1 - 0.084 13.0 0.0 0.13 12.4 0.0 1.3 1 0 0 1 1 1 0 50S ribosome-binding GTPase NHL PF01436.21 ELR16354.1 - 1.2e-10 40.9 12.0 0.0038 17.2 0.0 6.5 7 0 0 7 7 7 3 NHL repeat SGL PF08450.12 ELR16354.1 - 1.4e-06 28.1 0.0 0.68 9.5 0.0 3.7 1 1 3 4 4 4 3 SMP-30/Gluconolactonase/LRE-like region DUF5128 PF17170.4 ELR16354.1 - 0.011 14.9 0.1 4.6 6.3 0.0 3.1 3 1 0 3 3 3 0 6-bladed beta-propeller DUF4774 PF15999.5 ELR16354.1 - 1.3 8.9 7.9 5 7.0 0.1 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF4774) RNA_pol_Rpb1_2 PF00623.20 ELR16355.1 - 5.5e-66 221.9 0.0 1.3e-65 220.6 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_5 PF04998.17 ELR16355.1 - 8.2e-57 192.6 0.1 2.5e-54 184.5 0.0 2.9 2 1 0 2 2 2 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_3 PF04983.18 ELR16355.1 - 3.9e-34 117.8 0.0 1.3e-33 116.2 0.0 2.0 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_1 PF04997.12 ELR16355.1 - 3e-27 95.8 6.6 1.1e-24 87.4 5.8 3.1 2 1 0 2 2 2 1 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_4 PF05000.17 ELR16355.1 - 2.9e-21 75.4 0.1 2.9e-21 75.4 0.1 2.8 4 0 0 4 4 4 1 RNA polymerase Rpb1, domain 4 PUB PF09409.10 ELR16355.1 - 7.2e-06 25.8 0.0 2.2e-05 24.3 0.0 1.8 1 0 0 1 1 1 1 PUB domain BUD22 PF09073.10 ELR16355.1 - 0.18 11.1 53.9 0.021 14.2 31.0 2.2 2 0 0 2 2 2 0 BUD22 Presenilin PF01080.17 ELR16355.1 - 6.5 5.4 29.0 0.35 9.6 14.2 2.3 2 0 0 2 2 2 0 Presenilin rRNA_proc-arch PF13234.6 ELR16357.1 - 4.4e-84 282.6 0.1 8.6e-84 281.6 0.1 1.5 1 0 0 1 1 1 1 rRNA-processing arch domain DSHCT PF08148.12 ELR16357.1 - 2.6e-57 193.1 0.6 5.1e-57 192.1 0.6 1.5 1 0 0 1 1 1 1 DSHCT (NUC185) domain DEAD PF00270.29 ELR16357.1 - 6.9e-18 65.0 0.0 2.3e-17 63.3 0.0 1.9 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ELR16357.1 - 9.6e-08 32.4 0.0 6.9e-07 29.6 0.0 2.4 1 1 0 1 1 1 1 Helicase conserved C-terminal domain RhlB PF12300.8 ELR16357.1 - 0.32 11.1 3.6 0.58 10.3 3.6 1.3 1 0 0 1 1 1 0 ATP-dependent RNA helicase RhlB betaPIX_CC PF16523.5 ELR16357.1 - 8.7 6.2 9.2 1.1 9.2 1.0 3.4 4 0 0 4 4 4 0 betaPIX coiled coil NHL PF01436.21 ELR16358.1 - 4.3e-12 45.4 3.3 0.03 14.4 0.0 5.6 5 0 0 5 5 5 5 NHL repeat SGL PF08450.12 ELR16358.1 - 2e-07 30.9 0.0 0.25 10.9 0.0 3.6 1 1 2 3 3 3 3 SMP-30/Gluconolactonase/LRE-like region Phytase-like PF13449.6 ELR16358.1 - 0.00079 19.4 0.0 0.029 14.3 0.0 2.9 1 1 2 3 3 3 1 Esterase-like activity of phytase SdiA-regulated PF06977.11 ELR16358.1 - 0.0033 16.7 0.0 0.012 14.9 0.0 1.8 2 0 0 2 2 2 1 SdiA-regulated SBBP PF06739.11 ELR16358.1 - 0.31 11.1 0.8 2.7 8.1 0.0 2.6 3 0 0 3 3 3 0 Beta-propeller repeat Mito_carr PF00153.27 ELR16359.1 - 3.1e-11 43.0 0.0 1.2e-08 34.7 0.0 2.4 2 0 0 2 2 2 2 Mitochondrial carrier protein RasGEF_N PF00618.20 ELR16360.1 - 1.7e-18 66.8 1.3 3.4e-18 65.8 0.5 2.0 2 0 0 2 2 2 1 RasGEF N-terminal motif RasGEF PF00617.19 ELR16360.1 - 1.9e-17 64.0 0.3 3.4e-16 60.0 0.3 2.6 1 1 0 1 1 1 1 RasGEF domain DUF758 PF05527.11 ELR16360.1 - 0.041 13.9 0.0 0.11 12.4 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF758) Tubulin PF00091.25 ELR16361.1 - 3.7e-16 59.9 0.0 8.3e-16 58.8 0.0 1.5 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain z-alpha PF02295.17 ELR16361.1 - 0.069 13.2 0.3 2.5 8.2 0.0 2.6 3 0 0 3 3 3 0 Adenosine deaminase z-alpha domain Ham1p_like PF01725.16 ELR16362.1 - 3.2e-56 190.2 0.0 3.8e-56 190.0 0.0 1.1 1 0 0 1 1 1 1 Ham1 family F-box-like PF12937.7 ELR16365.1 - 3.2e-07 30.2 2.2 3.2e-07 30.2 2.2 2.2 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 ELR16365.1 - 0.024 14.5 0.5 0.024 14.5 0.5 1.5 2 0 0 2 2 2 0 F-box domain LCAT PF02450.15 ELR16366.1 - 1.1e-13 51.2 0.0 2.5e-13 50.0 0.0 1.5 1 1 0 1 1 1 1 Lecithin:cholesterol acyltransferase PGAP1 PF07819.13 ELR16366.1 - 0.014 15.2 0.0 0.027 14.2 0.0 1.5 2 0 0 2 2 2 0 PGAP1-like protein Hydrolase_4 PF12146.8 ELR16366.1 - 0.026 13.8 0.0 0.042 13.1 0.0 1.2 1 0 0 1 1 1 0 Serine aminopeptidase, S33 VPS9 PF02204.18 ELR16367.1 - 5.9e-16 58.6 0.0 1.4e-15 57.4 0.0 1.7 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain SBDS PF01172.18 ELR16368.1 - 1.8e-17 63.1 0.0 2.4e-17 62.8 0.0 1.1 1 0 0 1 1 1 1 Shwachman-Bodian-Diamond syndrome (SBDS) protein RRS1 PF04939.12 ELR16369.1 - 7.9e-54 181.9 8.0 7.9e-54 181.9 8.0 1.7 2 0 0 2 2 2 1 Ribosome biogenesis regulatory protein (RRS1) Med19 PF10278.9 ELR16370.1 - 1.2e-08 35.1 15.5 2.7e-08 34.0 15.4 1.6 1 1 0 1 1 1 1 Mediator of RNA pol II transcription subunit 19 AP3D1 PF06375.11 ELR16370.1 - 0.8 9.9 19.0 0.3 11.3 0.6 2.4 2 0 0 2 2 2 0 AP-3 complex subunit delta-1 MMADHC PF10229.9 ELR16371.1 - 1.6e-26 93.7 0.0 2.1e-26 93.3 0.0 1.1 1 0 0 1 1 1 1 Methylmalonic aciduria and homocystinuria type D protein Kelch_6 PF13964.6 ELR16372.1 - 4.1e-26 90.4 5.7 9.8e-09 35.2 0.0 6.4 5 1 1 6 6 6 4 Kelch motif Kelch_4 PF13418.6 ELR16372.1 - 1.4e-25 89.0 8.5 2.5e-07 30.6 0.1 6.8 6 0 0 6 6 6 6 Galactose oxidase, central domain Kelch_1 PF01344.25 ELR16372.1 - 1.1e-24 85.7 6.9 6e-09 35.3 0.0 6.3 6 1 0 6 6 6 4 Kelch motif Kelch_5 PF13854.6 ELR16372.1 - 2e-24 85.1 5.4 3.1e-06 27.0 0.1 6.5 6 0 0 6 6 6 4 Kelch motif BTB PF00651.31 ELR16372.1 - 2e-23 82.7 0.1 1.4e-20 73.5 0.0 2.3 1 1 1 2 2 2 2 BTB/POZ domain Kelch_3 PF13415.6 ELR16372.1 - 4.7e-19 68.2 27.8 4.2e-08 33.3 0.7 6.9 7 2 0 7 7 7 5 Galactose oxidase, central domain Kelch_2 PF07646.15 ELR16372.1 - 1.6e-18 65.9 8.2 2.2e-06 27.4 0.0 6.3 7 0 0 7 7 7 5 Kelch motif PQQ_3 PF13570.6 ELR16372.1 - 0.0047 17.4 2.9 3.6 8.2 0.1 3.7 3 0 0 3 3 3 2 PQQ-like domain RAP1 PF07218.11 ELR16375.1 - 0.95 7.7 5.0 1.2 7.4 5.0 1.0 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) SR-25 PF10500.9 ELR16375.1 - 3.8 7.1 12.1 5.1 6.6 12.1 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Beta_helix PF13229.6 ELR16376.1 - 3.3e-12 46.5 26.2 3.3e-06 27.1 8.7 2.1 1 1 1 2 2 2 2 Right handed beta helix region TGT PF01702.18 ELR16377.1 - 2e-148 494.3 0.0 2.5e-148 493.9 0.0 1.0 1 0 0 1 1 1 1 Queuine tRNA-ribosyltransferase Gal_Lectin PF02140.18 ELR16378.1 - 2.3e-07 31.1 0.4 2.3e-07 31.1 0.4 2.8 3 0 0 3 3 3 1 Galactose binding lectin domain VCBS PF13517.6 ELR16378.1 - 0.003 18.1 2.7 0.021 15.4 1.7 2.7 2 0 0 2 2 2 1 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella P_proprotein PF01483.20 ELR16378.1 - 0.02 14.9 0.1 0.048 13.7 0.1 1.7 1 0 0 1 1 1 0 Proprotein convertase P-domain FG-GAP PF01839.23 ELR16378.1 - 5.1 7.3 9.8 0.13 12.4 1.4 2.9 3 0 0 3 3 3 0 FG-GAP repeat BCD PF15461.6 ELR16379.1 - 0.1 12.1 1.1 0.16 11.4 1.1 1.2 1 0 0 1 1 1 0 Beta-carotene 15,15'-dioxygenase VCBS PF13517.6 ELR16381.1 - 0.00025 21.5 0.3 0.0015 19.1 0.5 2.2 1 1 1 2 2 2 1 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella PliI PF16743.5 ELR16381.1 - 0.041 13.6 0.0 0.082 12.7 0.0 1.5 1 0 0 1 1 1 0 Periplasmic lysozyme inhibitor of I-type lysozyme FG-GAP PF01839.23 ELR16381.1 - 0.046 13.9 0.7 0.046 13.9 0.7 2.1 2 0 0 2 2 2 0 FG-GAP repeat CytoC_RC PF02276.18 ELR16381.1 - 0.082 12.3 0.0 0.12 11.7 0.0 1.2 1 0 0 1 1 1 0 Photosynthetic reaction centre cytochrome C subunit CpeS PF09367.10 ELR16382.1 - 0.11 12.4 0.0 0.16 11.8 0.0 1.3 1 0 0 1 1 1 0 CpeS-like protein VCBS PF13517.6 ELR16384.1 - 4.7e-08 33.5 6.2 0.0022 18.5 1.3 3.8 2 1 0 2 2 2 2 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella Gal_Lectin PF02140.18 ELR16384.1 - 1.4e-07 31.9 1.4 2.8e-07 30.9 0.3 2.2 2 0 0 2 2 2 1 Galactose binding lectin domain FG-GAP PF01839.23 ELR16384.1 - 0.005 16.9 14.9 0.027 14.6 0.2 4.4 5 0 0 5 5 5 2 FG-GAP repeat P_proprotein PF01483.20 ELR16384.1 - 0.023 14.7 0.1 0.059 13.4 0.1 1.8 1 0 0 1 1 1 0 Proprotein convertase P-domain PRORP PF16953.5 ELR16386.1 - 0.0017 18.0 0.0 0.0018 17.8 0.0 1.0 1 0 0 1 1 1 1 Protein-only RNase P Chromo PF00385.24 ELR16387.1 - 2.8e-06 27.1 0.4 2.8e-06 27.1 0.4 1.7 1 1 1 2 2 2 1 Chromo (CHRromatin Organisation MOdifier) domain DHH PF01368.20 ELR16387.1 - 0.027 14.7 0.2 0.027 14.7 0.2 1.2 1 0 0 1 1 1 0 DHH family EGF PF00008.27 ELR16391.1 - 0.49 10.7 2.4 1.6 9.1 2.4 1.9 1 0 0 1 1 1 0 EGF-like domain VCBS PF13517.6 ELR16392.1 - 0.0014 19.1 0.3 0.0087 16.6 0.3 2.4 1 1 1 2 2 2 1 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.23 ELR16392.1 - 0.1 12.7 1.6 0.16 12.1 0.2 2.1 2 0 0 2 2 2 0 FG-GAP repeat DUF2428 PF10350.9 ELR16393.1 - 0.043 13.1 0.1 0.043 13.1 0.1 1.2 1 0 0 1 1 1 0 Putative death-receptor fusion protein (DUF2428) adh_short PF00106.25 ELR16395.1 - 5.2e-47 159.8 1.4 6.8e-47 159.4 1.4 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ELR16395.1 - 6.5e-32 111.0 0.8 8.6e-32 110.6 0.8 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ELR16395.1 - 6.3e-11 42.5 0.8 8.1e-11 42.2 0.8 1.2 1 0 0 1 1 1 1 KR domain DUF1776 PF08643.10 ELR16395.1 - 4.4e-10 39.4 0.0 8.7e-10 38.4 0.0 1.4 1 1 0 1 1 1 1 Fungal family of unknown function (DUF1776) Epimerase PF01370.21 ELR16395.1 - 0.0003 20.3 0.2 0.00083 18.9 0.2 1.7 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 ELR16395.1 - 0.00067 19.6 2.0 0.0016 18.4 1.1 2.2 2 1 0 2 2 2 1 NAD(P)H-binding NAD_binding_4 PF07993.12 ELR16395.1 - 0.0091 15.2 0.8 4.6 6.3 0.3 3.1 1 1 0 2 2 2 2 Male sterility protein NmrA PF05368.13 ELR16395.1 - 0.0095 15.5 0.7 0.016 14.8 0.7 1.4 1 1 0 1 1 1 1 NmrA-like family GDP_Man_Dehyd PF16363.5 ELR16395.1 - 0.013 15.0 0.2 0.09 12.2 0.1 2.1 2 1 0 2 2 2 0 GDP-mannose 4,6 dehydratase Tex_YqgF PF16921.5 ELR16395.1 - 0.093 13.2 0.2 19 5.8 0.0 2.3 2 0 0 2 2 2 0 Tex protein YqgF-like domain Glyco_hydro_3_C PF01915.22 ELR16397.1 - 8.5e-41 140.2 0.0 1.3e-40 139.5 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Glyco_hydro_3 PF00933.21 ELR16397.1 - 1.1e-39 136.7 0.0 1.5e-39 136.2 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Fn3-like PF14310.6 ELR16397.1 - 1.4e-15 57.1 0.0 5.2e-15 55.3 0.0 2.0 1 0 0 1 1 1 1 Fibronectin type III-like domain DUF11 PF01345.18 ELR16397.1 - 0.028 14.7 0.2 0.1 12.9 0.2 1.9 1 0 0 1 1 1 0 Domain of unknown function DUF11 FYVE PF01363.21 ELR16398.1 - 1.8e-20 72.8 10.5 2.7e-20 72.3 10.5 1.3 1 0 0 1 1 1 1 FYVE zinc finger FYVE_2 PF02318.16 ELR16398.1 - 0.03 14.5 8.1 0.051 13.8 8.1 1.3 1 0 0 1 1 1 0 FYVE-type zinc finger CIAPIN1 PF05093.13 ELR16399.1 - 1.4e-24 86.5 13.0 2.4e-19 69.7 2.9 2.3 1 1 1 2 2 2 2 Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis Methyltransf_11 PF08241.12 ELR16399.1 - 0.12 13.1 0.0 0.28 11.8 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain SAM_2 PF07647.17 ELR16400.1 - 0.00079 19.5 0.0 0.0021 18.1 0.0 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 ELR16400.1 - 0.045 14.2 0.0 0.18 12.3 0.0 1.9 2 0 0 2 2 2 0 SAM domain (Sterile alpha motif) Pox_Ag35 PF03286.14 ELR16400.1 - 0.25 11.1 8.1 0.52 10.1 8.1 1.5 1 0 0 1 1 1 0 Pox virus Ag35 surface protein Yippee-Mis18 PF03226.14 ELR16401.1 - 1.1e-16 60.9 0.3 1.4e-16 60.6 0.3 1.1 1 0 0 1 1 1 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly HNH_5 PF14279.6 ELR16401.1 - 0.00035 20.4 0.1 0.56 10.1 0.0 2.2 2 0 0 2 2 2 2 HNH endonuclease RIG-I_C-RD PF11648.8 ELR16401.1 - 0.0028 17.9 0.2 0.0037 17.5 0.2 1.2 1 0 0 1 1 1 1 C-terminal domain of RIG-I Cytochrome_C7 PF14522.6 ELR16401.1 - 0.0083 16.1 0.2 0.41 10.7 0.0 2.1 2 0 0 2 2 2 1 Cytochrome c7 and related cytochrome c zf_UBZ PF18439.1 ELR16401.1 - 0.018 14.7 0.4 0.27 10.9 0.1 2.2 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger Cytochrom_c3_2 PF14537.6 ELR16401.1 - 0.036 14.5 0.4 0.2 12.2 0.1 1.9 2 0 0 2 2 2 0 Cytochrome c3 zinc_ribbon_6 PF14599.6 ELR16401.1 - 0.045 13.8 2.1 0.25 11.4 0.1 2.2 2 0 0 2 2 2 0 Zinc-ribbon DUF678 PF05077.12 ELR16401.1 - 0.15 12.2 2.2 0.57 10.3 0.2 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF678) BET PF17035.5 ELR16402.1 - 2e-11 43.9 0.7 2.3e-11 43.7 0.7 1.1 1 0 0 1 1 1 1 Bromodomain extra-terminal - transcription regulation ABC2_membrane PF01061.24 ELR16403.1 - 1e-77 260.3 38.2 8.7e-40 136.4 21.6 2.4 2 0 0 2 2 2 2 ABC-2 type transporter ABC_tran PF00005.27 ELR16403.1 - 7.3e-50 169.0 0.1 5.8e-26 91.6 0.0 2.5 2 0 0 2 2 2 2 ABC transporter RsgA_GTPase PF03193.16 ELR16403.1 - 4.8e-10 39.6 0.1 0.00018 21.4 0.0 2.4 2 0 0 2 2 2 2 RsgA GTPase AAA_29 PF13555.6 ELR16403.1 - 3e-08 33.3 0.2 0.005 16.6 0.1 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_21 PF13304.6 ELR16403.1 - 3.2e-08 33.8 0.0 0.76 9.5 0.0 4.3 4 0 0 4 4 4 3 AAA domain, putative AbiEii toxin, Type IV TA system AAA_16 PF13191.6 ELR16403.1 - 3.8e-08 33.9 0.1 0.0084 16.5 0.0 2.7 2 0 0 2 2 2 2 AAA ATPase domain AAA_22 PF13401.6 ELR16403.1 - 6.4e-07 29.7 0.0 0.036 14.3 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_25 PF13481.6 ELR16403.1 - 1.3e-06 28.2 0.0 0.067 12.8 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_18 PF13238.6 ELR16403.1 - 2.5e-05 24.8 0.0 0.28 11.7 0.0 2.9 2 0 0 2 2 2 2 AAA domain AAA_33 PF13671.6 ELR16403.1 - 3.9e-05 23.8 1.4 0.31 11.2 0.0 3.0 3 0 0 3 3 2 2 AAA domain Rad17 PF03215.15 ELR16403.1 - 3.9e-05 23.6 0.3 0.15 12.0 0.0 2.8 3 0 0 3 3 2 2 Rad17 P-loop domain MMR_HSR1 PF01926.23 ELR16403.1 - 0.00022 21.3 0.3 0.73 9.9 0.0 2.6 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_28 PF13521.6 ELR16403.1 - 0.0003 21.1 3.0 0.19 12.0 0.2 2.6 2 0 0 2 2 2 2 AAA domain AAA PF00004.29 ELR16403.1 - 0.0011 19.3 0.3 0.15 12.4 0.0 2.9 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 ELR16403.1 - 0.0021 18.1 0.4 0.22 11.5 0.1 2.7 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) G-alpha PF00503.20 ELR16403.1 - 0.0025 17.0 0.3 0.89 8.6 0.1 2.7 2 1 1 3 3 3 1 G-protein alpha subunit RNA_helicase PF00910.22 ELR16403.1 - 0.0026 18.1 0.1 1.5 9.2 0.0 2.7 2 0 0 2 2 2 1 RNA helicase AAA_14 PF13173.6 ELR16403.1 - 0.0026 17.8 0.0 0.24 11.4 0.0 2.7 2 0 0 2 2 2 1 AAA domain Zeta_toxin PF06414.12 ELR16403.1 - 0.0037 16.6 1.3 1.2 8.4 0.0 2.3 2 0 0 2 2 2 2 Zeta toxin AAA_30 PF13604.6 ELR16403.1 - 0.0043 16.8 0.4 3.1 7.5 0.1 2.4 2 0 0 2 2 2 2 AAA domain NACHT PF05729.12 ELR16403.1 - 0.0045 16.9 4.2 0.14 12.0 0.1 2.7 3 0 0 3 3 2 1 NACHT domain DUF815 PF05673.13 ELR16403.1 - 0.0056 15.9 0.2 1.2 8.3 0.0 2.4 2 0 0 2 2 2 1 Protein of unknown function (DUF815) Viral_helicase1 PF01443.18 ELR16403.1 - 0.014 15.2 0.3 0.16 11.7 0.0 2.3 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase DUF87 PF01935.17 ELR16403.1 - 0.031 14.4 0.5 2.4 8.2 0.2 2.6 2 0 0 2 2 2 0 Helicase HerA, central domain ATPase_2 PF01637.18 ELR16403.1 - 0.032 14.2 0.0 0.62 9.9 0.0 2.2 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea AAA_24 PF13479.6 ELR16403.1 - 0.045 13.5 0.5 13 5.4 0.1 2.7 2 0 0 2 2 2 0 AAA domain ABC2_membrane_3 PF12698.7 ELR16403.1 - 0.047 12.8 44.4 0.34 10.0 20.0 3.7 3 1 1 4 4 4 0 ABC-2 family transporter protein AAA_23 PF13476.6 ELR16403.1 - 0.055 14.0 7.8 0.88 10.0 0.0 3.4 3 1 0 3 3 3 0 AAA domain NTPase_1 PF03266.15 ELR16403.1 - 0.056 13.4 0.7 43 4.0 0.1 3.3 3 0 0 3 3 3 0 NTPase MeaB PF03308.16 ELR16403.1 - 0.064 12.2 0.1 11 4.8 0.0 2.4 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB cobW PF02492.19 ELR16403.1 - 0.093 12.3 2.3 3 7.4 0.2 2.3 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain DUF389 PF04087.14 ELR16403.1 - 0.16 12.0 2.3 0.49 10.4 0.9 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF389) APS_kinase PF01583.20 ELR16403.1 - 0.23 11.4 0.5 3.3 7.6 0.0 2.9 3 0 0 3 3 3 0 Adenylylsulphate kinase Ploopntkinase3 PF18751.1 ELR16403.1 - 0.23 11.4 1.9 11 5.9 0.1 2.9 4 0 0 4 4 2 0 P-loop Nucleotide Kinase3 Mg_chelatase PF01078.21 ELR16403.1 - 0.26 10.6 1.9 0.79 9.1 0.1 2.2 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI PDR_CDR PF06422.12 ELR16403.1 - 0.27 11.1 7.5 1.3 9.0 0.0 3.6 3 0 0 3 3 3 0 CDR ABC transporter AAA_17 PF13207.6 ELR16403.1 - 0.41 11.1 5.0 2.5 8.5 0.0 2.8 3 0 0 3 3 2 0 AAA domain Ribosomal_L1 PF00687.21 ELR16405.1 - 2.6e-13 50.2 0.0 6.1e-13 49.0 0.0 1.6 1 1 0 1 1 1 1 Ribosomal protein L1p/L10e family F-box-like PF12937.7 ELR16405.1 - 4.2e-09 36.2 1.4 1.1e-08 34.8 1.4 1.8 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ELR16405.1 - 0.00016 21.5 2.6 0.00049 19.9 2.1 2.1 2 0 0 2 2 2 1 F-box domain F-box_5 PF18511.1 ELR16405.1 - 0.084 12.5 0.4 0.18 11.4 0.4 1.5 1 0 0 1 1 1 0 F-box F-box_4 PF15966.5 ELR16405.1 - 0.24 11.3 2.2 0.18 11.7 0.3 1.7 2 0 0 2 2 2 0 F-box NDK PF00334.19 ELR16406.1 - 6.9e-07 29.4 0.0 1.4e-06 28.4 0.0 1.5 1 0 0 1 1 1 1 Nucleoside diphosphate kinase FERM_M PF00373.18 ELR16407.1 - 1.4e-24 86.8 0.0 4.2e-24 85.2 0.0 1.9 1 0 0 1 1 1 1 FERM central domain FERM_f0 PF16511.5 ELR16407.1 - 9.7e-21 73.9 0.0 2.6e-19 69.3 0.0 2.6 2 0 0 2 2 2 1 N-terminal or F0 domain of Talin-head FERM FERM_N PF09379.10 ELR16407.1 - 3.3e-13 49.4 0.1 1.2e-12 47.6 0.0 2.1 3 0 0 3 3 3 1 FERM N-terminal domain TruB-C_2 PF09157.11 ELR16407.1 - 0.028 14.4 0.1 0.073 13.1 0.1 1.7 1 0 0 1 1 1 0 Pseudouridine synthase II TruB, C-terminal ACBP PF00887.19 ELR16407.1 - 0.039 14.2 0.0 0.16 12.2 0.0 2.1 1 0 0 1 1 1 0 Acyl CoA binding protein MFS_1 PF07690.16 ELR16408.1 - 5.2e-11 42.1 25.6 6.5e-11 41.7 21.9 2.4 2 1 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 ELR16408.1 - 0.00086 18.3 1.4 0.00086 18.3 1.4 1.6 1 1 1 2 2 2 1 Sugar (and other) transporter Pkinase_Tyr PF07714.17 ELR16409.1 - 1.1e-55 188.7 0.0 1.1e-53 182.1 0.0 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ELR16409.1 - 3.2e-40 138.2 0.0 2.4e-39 135.3 0.0 1.9 1 1 0 1 1 1 1 Protein kinase domain Pkinase_fungal PF17667.1 ELR16409.1 - 0.00023 20.1 0.0 0.00041 19.2 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 ELR16409.1 - 0.012 15.0 0.0 0.018 14.4 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family CH PF00307.31 ELR16410.1 - 4.8e-19 68.6 0.0 6.1e-19 68.2 0.0 1.1 1 0 0 1 1 1 1 Calponin homology (CH) domain zinc_ribbon_2 PF13240.6 ELR16410.1 - 8.3e-08 31.7 6.1 4.4e-07 29.4 4.8 2.2 2 0 0 2 2 2 1 zinc-ribbon domain DZR PF12773.7 ELR16410.1 - 9.1e-07 28.8 0.6 1.6e-06 28.0 0.6 1.4 1 0 0 1 1 1 1 Double zinc ribbon zf-ribbon_3 PF13248.6 ELR16410.1 - 6.1e-06 25.5 3.7 9.7e-06 24.8 3.7 1.3 1 0 0 1 1 1 1 zinc-ribbon domain Nudix_N_2 PF14803.6 ELR16410.1 - 0.00027 20.8 3.8 0.22 11.5 0.1 2.6 3 0 0 3 3 3 2 Nudix N-terminal CDC24 PF06395.11 ELR16410.1 - 0.0035 17.6 0.0 0.0054 17.0 0.0 1.3 1 0 0 1 1 1 1 CDC24 Calponin zf-NADH-PPase PF09297.11 ELR16410.1 - 0.0037 16.9 5.7 0.13 12.0 0.9 2.6 2 0 0 2 2 2 2 NADH pyrophosphatase zinc ribbon domain CAMSAP_CH PF11971.8 ELR16410.1 - 0.031 14.1 0.0 0.047 13.5 0.0 1.3 1 0 0 1 1 1 0 CAMSAP CH domain RNA_POL_M_15KD PF02150.16 ELR16410.1 - 0.063 13.2 2.8 0.93 9.4 0.1 2.3 2 0 0 2 2 2 0 RNA polymerases M/15 Kd subunit zinc_ribbon_15 PF17032.5 ELR16410.1 - 0.29 11.9 2.6 0.53 11.1 2.6 1.4 1 0 0 1 1 1 0 zinc-ribbon family RecR PF02132.15 ELR16410.1 - 3.9 7.1 6.1 86 2.8 4.6 3.1 2 1 0 2 2 2 0 RecR protein NOB1_Zn_bind PF08772.11 ELR16410.1 - 8.9 6.6 7.2 79 3.5 7.2 2.3 1 1 0 1 1 1 0 Nin one binding (NOB1) Zn-ribbon like Abhydrolase_1 PF00561.20 ELR16411.1 - 1.4e-35 123.2 0.0 2e-35 122.7 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 ELR16411.1 - 3.1e-14 52.8 0.0 1.8e-13 50.3 0.0 2.0 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 ELR16411.1 - 6.7e-10 39.9 1.0 1.1e-09 39.2 1.0 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_4 PF08386.10 ELR16411.1 - 0.00013 22.0 0.0 0.00023 21.2 0.0 1.4 1 0 0 1 1 1 1 TAP-like protein Peptidase_S9 PF00326.21 ELR16411.1 - 0.014 14.9 0.1 0.96 8.9 0.0 2.6 2 1 1 3 3 3 0 Prolyl oligopeptidase family Ndr PF03096.14 ELR16411.1 - 0.023 13.4 0.0 0.034 12.9 0.0 1.2 1 0 0 1 1 1 0 Ndr family zf-RanBP PF00641.18 ELR16412.1 - 1.7e-10 40.0 9.7 7.1e-06 25.2 1.9 2.4 2 0 0 2 2 2 2 Zn-finger in Ran binding protein and others RecR PF02132.15 ELR16412.1 - 10 5.8 10.7 7.8 6.2 2.6 2.3 2 0 0 2 2 2 0 RecR protein zf-RanBP PF00641.18 ELR16413.1 - 1.3e-05 24.4 2.5 2.2e-05 23.6 0.6 2.3 2 0 0 2 2 2 1 Zn-finger in Ran binding protein and others DUF898 PF05987.13 ELR16414.1 - 0.00058 19.0 0.2 0.0014 17.7 0.1 1.7 2 0 0 2 2 2 1 Bacterial protein of unknown function (DUF898) RUN PF02759.19 ELR16415.1 - 9.6e-22 77.4 0.1 1.5e-21 76.8 0.1 1.3 1 0 0 1 1 1 1 RUN domain MazG-like PF12643.7 ELR16415.1 - 7.3e-10 39.0 0.0 1.5e-09 38.0 0.0 1.5 1 0 0 1 1 1 1 MazG-like family MazG PF03819.17 ELR16415.1 - 4.5e-06 26.7 0.0 1.1e-05 25.4 0.0 1.7 1 0 0 1 1 1 1 MazG nucleotide pyrophosphohydrolase domain Pox_Ag35 PF03286.14 ELR16415.1 - 0.81 9.4 4.8 1.7 8.4 4.8 1.5 1 0 0 1 1 1 0 Pox virus Ag35 surface protein F1F0-ATPsyn_F PF10791.9 ELR16416.1 - 0.03 14.8 0.0 0.036 14.5 0.0 1.2 1 0 0 1 1 1 0 Mitochondrial F1-F0 ATP synthase subunit F of fungi PGM1_C PF18105.1 ELR16417.1 - 5.3e-07 29.1 0.0 1.4e-06 27.7 0.0 1.8 1 0 0 1 1 1 1 PGM1 C-terminal domain Polyketide_cyc2 PF10604.9 ELR16418.1 - 5e-14 52.8 1.3 5.6e-14 52.6 1.3 1.0 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport 2-oxoacid_dh PF00198.23 ELR16419.1 - 4e-83 278.4 0.0 5.1e-83 278.1 0.0 1.1 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.22 ELR16419.1 - 1.1e-15 57.2 1.5 2e-15 56.4 1.5 1.4 1 0 0 1 1 1 1 Biotin-requiring enzyme HlyD_3 PF13437.6 ELR16419.1 - 0.013 16.2 0.5 0.25 12.1 0.0 2.4 1 1 1 2 2 2 0 HlyD family secretion protein HSP70 PF00012.20 ELR16420.1 - 5.6e-169 563.1 5.2 1.7e-167 558.2 2.9 2.3 1 1 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 ELR16420.1 - 1.5e-13 50.3 0.1 1.5e-11 43.7 0.0 2.2 2 0 0 2 2 2 2 MreB/Mbl protein Phage_TAC_7 PF10109.9 ELR16420.1 - 0.0029 17.7 2.8 4 7.6 0.1 3.6 3 0 0 3 3 3 2 Phage tail assembly chaperone proteins, E, or 41 or 14 SspH PF08141.12 ELR16420.1 - 0.0099 16.0 0.0 2 8.6 0.0 2.9 2 0 0 2 2 2 1 Small acid-soluble spore protein H family FGGY_C PF02782.16 ELR16420.1 - 0.017 14.8 0.0 0.05 13.3 0.0 1.9 1 0 0 1 1 1 0 FGGY family of carbohydrate kinases, C-terminal domain MIR PF02815.19 ELR16420.1 - 0.16 11.8 0.5 0.33 10.8 0.5 1.6 1 0 0 1 1 1 0 MIR domain FtsA PF14450.6 ELR16420.1 - 0.27 11.7 0.0 0.27 11.7 0.0 3.2 3 2 0 3 3 3 0 Cell division protein FtsA Ribosomal_60s PF00428.19 ELR16420.1 - 3.3 8.4 32.4 0.1 13.2 6.0 3.1 3 0 0 3 3 3 0 60s Acidic ribosomal protein RhoGEF PF00621.20 ELR16421.1 - 1.3e-20 74.4 0.1 2.3e-20 73.6 0.1 1.4 1 0 0 1 1 1 1 RhoGEF domain CH PF00307.31 ELR16421.1 - 1.4e-11 44.5 0.0 3.7e-10 39.9 0.0 2.2 2 0 0 2 2 2 1 Calponin homology (CH) domain PH_13 PF16652.5 ELR16421.1 - 0.069 13.0 0.1 0.33 10.8 0.0 2.1 1 1 1 2 2 2 0 Pleckstrin homology domain ROS_MUCR PF05443.11 ELR16421.1 - 0.34 10.9 1.6 0.51 10.4 0.4 1.9 2 0 0 2 2 2 0 ROS/MUCR transcriptional regulator protein PAN_4 PF14295.6 ELR16423.1 - 3.7e-05 23.6 3.1 3.7e-05 23.6 3.1 3.8 4 1 0 4 4 4 1 PAN domain hEGF PF12661.7 ELR16423.1 - 0.027 15.1 40.7 0.039 14.6 6.9 5.6 5 0 0 5 5 5 0 Human growth factor-like EGF E3_UFM1_ligase PF09743.9 ELR16424.1 - 2.3e-23 83.2 0.0 4.4e-23 82.3 0.0 1.5 1 0 0 1 1 1 1 E3 UFM1-protein ligase 1 BDM PF10684.9 ELR16424.1 - 0.061 13.7 0.0 0.15 12.4 0.0 1.6 1 0 0 1 1 1 0 Putative biofilm-dependent modulation protein DNA_pol_A_exo1 PF01612.20 ELR16424.1 - 0.066 12.9 0.4 0.14 11.8 0.4 1.5 1 0 0 1 1 1 0 3'-5' exonuclease EIID-AGA PF03613.14 ELR16424.1 - 0.23 10.6 0.0 0.36 10.0 0.0 1.2 1 0 0 1 1 1 0 PTS system mannose/fructose/sorbose family IID component TipAS PF07739.13 ELR16424.1 - 1.4 9.5 6.1 0.76 10.3 0.4 2.8 2 1 1 3 3 3 0 TipAS antibiotic-recognition domain Pex19 PF04614.12 ELR16425.1 - 1.5e-31 110.0 12.3 3.6e-31 108.8 12.3 1.7 1 1 0 1 1 1 1 Pex19 protein family K_channel_TID PF07941.11 ELR16425.1 - 0.18 12.3 5.7 0.33 11.4 5.7 1.4 1 0 0 1 1 1 0 Potassium channel Kv1.4 tandem inactivation domain Ribosomal_60s PF00428.19 ELR16425.1 - 0.42 11.2 10.2 1 10.0 10.2 1.7 1 0 0 1 1 1 0 60s Acidic ribosomal protein Metallophos PF00149.28 ELR16426.1 - 7.4e-38 131.1 0.0 9.8e-38 130.7 0.0 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Glyco_hydro_65N PF03636.15 ELR16426.1 - 0.13 11.8 0.0 0.2 11.3 0.0 1.1 1 0 0 1 1 1 0 Glycosyl hydrolase family 65, N-terminal domain 23S_rRNA_IVP PF05635.11 ELR16426.1 - 0.17 12.2 0.1 0.49 10.7 0.1 1.8 2 0 0 2 2 2 0 23S rRNA-intervening sequence protein Pkinase_Tyr PF07714.17 ELR16427.1 - 9.2e-56 189.0 0.0 1.6e-55 188.2 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ELR16427.1 - 6.3e-50 170.0 0.0 1.2e-49 169.1 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_fungal PF17667.1 ELR16427.1 - 2.1e-05 23.5 1.2 0.00022 20.2 0.0 2.1 2 0 0 2 2 2 1 Fungal protein kinase Presenilin PF01080.17 ELR16427.1 - 0.63 8.8 3.4 1.5 7.5 2.8 1.7 2 0 0 2 2 2 0 Presenilin TAF4 PF05236.14 ELR16427.1 - 0.72 9.5 13.5 1.2 8.8 13.5 1.3 1 0 0 1 1 1 0 Transcription initiation factor TFIID component TAF4 family RNA_polI_A34 PF08208.11 ELR16427.1 - 0.91 9.6 18.1 1.8 8.6 18.1 1.4 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 CPSF100_C PF13299.6 ELR16427.1 - 1.9 8.6 7.6 3.5 7.8 7.6 1.4 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal RNA_pol_Rpc4 PF05132.14 ELR16427.1 - 3.7 8.0 10.4 0.92 9.9 6.7 1.9 2 0 0 2 2 2 0 RNA polymerase III RPC4 NPR3 PF03666.13 ELR16427.1 - 7.1 5.3 6.9 9.6 4.9 6.9 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 CytochromB561_N PF09786.9 ELR16427.1 - 9.7 5.0 8.9 16 4.3 8.9 1.3 1 0 0 1 1 1 0 Cytochrome B561, N terminal Abhydrolase_1 PF00561.20 ELR16428.1 - 4.6e-15 55.9 0.1 4.9e-12 46.0 0.3 2.1 1 1 0 2 2 2 2 alpha/beta hydrolase fold Abhydro_lipase PF04083.16 ELR16428.1 - 9.5e-14 50.7 0.0 1.7e-13 50.0 0.0 1.4 1 0 0 1 1 1 1 Partial alpha/beta-hydrolase lipase region Hydrolase_4 PF12146.8 ELR16428.1 - 3.3e-05 23.3 0.0 0.00048 19.5 0.0 2.2 2 0 0 2 2 2 1 Serine aminopeptidase, S33 RhoGEF PF00621.20 ELR16429.1 - 1.3e-42 146.1 0.7 3e-42 144.9 0.7 1.6 1 0 0 1 1 1 1 RhoGEF domain CH PF00307.31 ELR16429.1 - 4.6e-39 133.0 1.7 3.4e-16 59.4 0.0 3.8 3 1 0 3 3 3 3 Calponin homology (CH) domain PH PF00169.29 ELR16429.1 - 0.0024 18.3 0.0 0.011 16.3 0.0 2.1 1 0 0 1 1 1 1 PH domain CDC24 PF06395.11 ELR16429.1 - 0.02 15.1 0.7 1.1 9.5 0.1 3.3 2 1 1 3 3 3 0 CDC24 Calponin Methyltransf_34 PF11312.8 ELR16429.1 - 0.023 13.9 1.2 0.046 13.0 1.2 1.4 1 0 0 1 1 1 0 Putative SAM-dependent methyltransferase DUF4065 PF13274.6 ELR16429.1 - 1.9 9.4 8.9 0.63 11.0 0.1 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF4065) DUF572 PF04502.13 ELR16429.1 - 8.7 5.9 25.8 3.5 7.2 16.6 2.8 3 0 0 3 3 3 0 Family of unknown function (DUF572) RR_TM4-6 PF06459.12 ELR16429.1 - 9 6.0 20.8 19 5.0 20.8 1.5 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 CDC45 PF02724.14 ELR16429.1 - 9.1 4.4 18.9 14 3.8 18.9 1.2 1 0 0 1 1 1 0 CDC45-like protein Pmp3 PF01679.17 ELR16430.1 - 6.6e-18 64.7 14.8 7.5e-18 64.5 14.8 1.0 1 0 0 1 1 1 1 Proteolipid membrane potential modulator SLC3A2_N PF16028.5 ELR16430.1 - 0.091 12.3 0.9 0.15 11.7 0.9 1.3 1 0 0 1 1 1 0 Solute carrier family 3 member 2 N-terminus zf-RING_2 PF13639.6 ELR16431.1 - 6.6e-09 36.0 0.9 6.6e-09 36.0 0.9 2.1 3 0 0 3 3 3 1 Ring finger domain zf-RING_11 PF17123.5 ELR16431.1 - 9.3e-07 28.5 0.8 2.2e-06 27.3 0.8 1.6 1 0 0 1 1 1 1 RING-like zinc finger zf-rbx1 PF12678.7 ELR16431.1 - 8.5e-06 26.0 2.4 8.5e-06 26.0 2.4 2.4 2 1 0 2 2 2 1 RING-H2 zinc finger domain zf-RING_UBOX PF13445.6 ELR16431.1 - 0.00044 20.2 1.7 0.0022 18.0 1.1 2.2 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 ELR16431.1 - 0.00063 19.5 1.3 0.00063 19.5 1.3 1.9 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 ELR16431.1 - 0.0079 16.0 0.6 0.0079 16.0 0.6 2.4 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ELR16431.1 - 0.0084 16.0 0.3 0.02 14.8 0.3 1.7 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 ELR16431.1 - 0.0098 15.7 0.5 0.022 14.6 0.5 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_14 PF17978.1 ELR16431.1 - 0.017 15.5 0.1 0.04 14.4 0.1 1.5 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain Zn_ribbon_17 PF17120.5 ELR16431.1 - 0.052 13.2 1.1 0.052 13.2 1.1 2.0 2 0 0 2 2 2 0 Zinc-ribbon, C4HC2 type Vps39_2 PF10367.9 ELR16431.1 - 0.14 12.6 0.5 0.29 11.6 0.5 1.5 1 0 0 1 1 1 0 Vacuolar sorting protein 39 domain 2 zf-ANAPC11 PF12861.7 ELR16431.1 - 0.25 11.4 1.8 0.87 9.7 1.8 1.9 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger RINGv PF12906.7 ELR16431.1 - 0.36 11.0 3.5 0.32 11.2 1.1 2.2 2 0 0 2 2 2 0 RING-variant domain Prok-RING_1 PF14446.6 ELR16431.1 - 0.37 10.8 4.6 0.97 9.4 1.0 2.6 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 HtrL_YibB PF09612.10 ELR16432.1 - 8.6e-09 35.3 0.0 1.8e-08 34.2 0.0 1.6 1 1 0 1 1 1 1 Bacterial protein of unknown function (HtrL_YibB) DASH_Spc19 PF08287.11 ELR16434.1 - 6.3e-06 26.2 2.7 0.0051 16.7 0.4 2.4 1 1 1 2 2 2 2 Spc19 Phage_GP20 PF06810.11 ELR16434.1 - 0.00049 19.9 0.8 0.0006 19.6 0.8 1.1 1 0 0 1 1 1 1 Phage minor structural protein GP20 Fib_alpha PF08702.10 ELR16434.1 - 0.00052 20.2 0.1 0.00075 19.7 0.1 1.1 1 0 0 1 1 1 1 Fibrinogen alpha/beta chain family TBCA PF02970.16 ELR16434.1 - 0.00062 20.0 1.0 0.001 19.4 1.0 1.4 1 1 0 1 1 1 1 Tubulin binding cofactor A ADIP PF11559.8 ELR16434.1 - 0.00085 19.4 2.7 0.0011 19.1 2.7 1.1 1 0 0 1 1 1 1 Afadin- and alpha -actinin-Binding TMF_DNA_bd PF12329.8 ELR16434.1 - 0.00095 19.1 1.0 0.0015 18.5 1.0 1.4 1 0 0 1 1 1 1 TATA element modulatory factor 1 DNA binding APG6_N PF17675.1 ELR16434.1 - 0.00098 19.7 0.7 0.0012 19.3 0.7 1.1 1 0 0 1 1 1 1 Apg6 coiled-coil region bZIP_1 PF00170.21 ELR16434.1 - 0.00098 19.2 7.1 0.015 15.4 0.7 2.4 1 1 2 3 3 3 2 bZIP transcription factor Prefoldin PF02996.17 ELR16434.1 - 0.0013 18.6 1.1 0.0019 18.1 1.1 1.2 1 0 0 1 1 1 1 Prefoldin subunit Tektin PF03148.14 ELR16434.1 - 0.0013 17.5 0.9 0.0015 17.3 0.9 1.1 1 0 0 1 1 1 1 Tektin family Exonuc_VII_S PF02609.16 ELR16434.1 - 0.0015 18.6 3.8 0.015 15.3 1.9 2.0 1 1 1 2 2 2 2 Exonuclease VII small subunit ZapB PF06005.12 ELR16434.1 - 0.0015 18.9 2.5 0.0026 18.2 2.5 1.4 1 0 0 1 1 1 1 Cell division protein ZapB ATG16 PF08614.11 ELR16434.1 - 0.0019 18.5 5.0 0.0024 18.2 5.0 1.1 1 0 0 1 1 1 1 Autophagy protein 16 (ATG16) SlyX PF04102.12 ELR16434.1 - 0.002 18.7 1.4 0.003 18.1 1.4 1.3 1 0 0 1 1 1 1 SlyX PspA_IM30 PF04012.12 ELR16434.1 - 0.0025 17.4 1.5 0.0037 16.9 1.5 1.3 1 0 0 1 1 1 1 PspA/IM30 family FlaC_arch PF05377.11 ELR16434.1 - 0.0042 17.5 1.9 0.011 16.1 1.9 1.7 1 1 0 1 1 1 1 Flagella accessory protein C (FlaC) COG5 PF10392.9 ELR16434.1 - 0.0046 17.1 1.4 0.021 15.0 1.0 1.7 1 1 0 1 1 1 1 Golgi transport complex subunit 5 DUF16 PF01519.16 ELR16434.1 - 0.0046 17.4 0.4 0.0059 17.1 0.4 1.2 1 0 0 1 1 1 1 Protein of unknown function DUF16 CLZ PF16526.5 ELR16434.1 - 0.0049 17.2 2.8 0.017 15.5 2.8 1.9 1 1 0 1 1 1 1 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Cnn_1N PF07989.11 ELR16434.1 - 0.0051 16.9 0.3 0.009 16.1 0.2 1.4 1 1 0 1 1 1 1 Centrosomin N-terminal motif 1 BLOC1_2 PF10046.9 ELR16434.1 - 0.0055 17.0 2.4 0.017 15.4 2.4 1.7 1 1 0 1 1 1 1 Biogenesis of lysosome-related organelles complex-1 subunit 2 Prominin PF05478.11 ELR16434.1 - 0.0064 14.5 0.3 0.0071 14.4 0.3 1.0 1 0 0 1 1 1 1 Prominin XhlA PF10779.9 ELR16434.1 - 0.0066 16.6 0.5 0.011 16.0 0.5 1.3 1 0 0 1 1 1 1 Haemolysin XhlA Spc7 PF08317.11 ELR16434.1 - 0.0078 15.1 3.6 0.0094 14.9 3.6 1.1 1 0 0 1 1 1 1 Spc7 kinetochore protein DUF1664 PF07889.12 ELR16434.1 - 0.0078 16.2 0.2 0.01 15.9 0.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1664) Trimer_CC PF08954.11 ELR16434.1 - 0.0079 15.7 4.2 0.011 15.2 2.6 2.0 1 1 1 2 2 2 1 Trimerisation motif YabA PF06156.13 ELR16434.1 - 0.0083 16.7 0.4 0.011 16.4 0.4 1.2 1 0 0 1 1 1 1 Initiation control protein YabA GCR PF02155.15 ELR16434.1 - 0.0089 15.1 0.2 0.012 14.7 0.2 1.2 1 0 0 1 1 1 1 Glucocorticoid receptor Phage_GPO PF05929.11 ELR16434.1 - 0.012 15.3 2.2 0.015 15.0 2.2 1.1 1 0 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase Baculo_PEP_C PF04513.12 ELR16434.1 - 0.013 15.6 0.1 0.016 15.2 0.1 1.1 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus CENP-Q PF13094.6 ELR16434.1 - 0.013 15.7 2.5 0.014 15.6 2.5 1.1 1 0 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit TSC22 PF01166.18 ELR16434.1 - 0.015 15.6 2.3 0.31 11.4 0.5 2.1 1 1 1 2 2 2 0 TSC-22/dip/bun family V_ATPase_I PF01496.19 ELR16434.1 - 0.016 13.2 0.3 0.017 13.1 0.3 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family bZIP_2 PF07716.15 ELR16434.1 - 0.018 15.1 2.0 0.34 11.0 0.2 3.2 1 1 2 3 3 3 0 Basic region leucine zipper Atg14 PF10186.9 ELR16434.1 - 0.018 14.2 0.9 0.021 13.9 0.9 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Prefoldin_2 PF01920.20 ELR16434.1 - 0.018 15.0 2.1 0.027 14.4 2.0 1.4 1 1 0 1 1 1 0 Prefoldin subunit DivIC PF04977.15 ELR16434.1 - 0.018 14.8 1.4 0.032 14.0 0.8 1.8 1 1 1 2 2 2 0 Septum formation initiator FmiP_Thoc5 PF09766.9 ELR16434.1 - 0.019 14.3 0.8 0.023 14.0 0.8 1.1 1 0 0 1 1 1 0 Fms-interacting protein/Thoc5 Csm1_N PF18504.1 ELR16434.1 - 0.021 15.2 3.3 0.088 13.2 2.3 2.1 1 1 1 2 2 2 0 Csm1 N-terminal domain GIT_CC PF16559.5 ELR16434.1 - 0.022 14.6 0.3 0.032 14.1 0.3 1.2 1 0 0 1 1 1 0 GIT coiled-coil Rho guanine nucleotide exchange factor DUF4795 PF16043.5 ELR16434.1 - 0.025 14.2 0.3 0.03 13.9 0.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4795) DUF3972 PF13118.6 ELR16434.1 - 0.025 15.0 1.3 0.036 14.5 1.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3972) Ax_dynein_light PF10211.9 ELR16434.1 - 0.026 14.5 3.3 0.051 13.5 3.3 1.5 1 1 0 1 1 1 0 Axonemal dynein light chain DASH_Dam1 PF08653.10 ELR16434.1 - 0.027 14.3 0.1 0.16 11.8 0.1 2.0 1 1 0 1 1 1 0 DASH complex subunit Dam1 DUF4988 PF16378.5 ELR16434.1 - 0.027 14.2 0.5 0.084 12.5 0.5 1.8 1 1 0 1 1 1 0 Domain of unknown function DUF812 PF05667.11 ELR16434.1 - 0.029 13.3 3.0 0.032 13.1 3.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF812) Lzipper-MIP1 PF14389.6 ELR16434.1 - 0.03 14.6 4.6 0.57 10.5 2.2 2.4 1 1 2 3 3 3 0 Leucine-zipper of ternary complex factor MIP1 TMCO5 PF14992.6 ELR16434.1 - 0.042 13.4 1.5 0.05 13.2 1.5 1.1 1 0 0 1 1 1 0 TMCO5 family DUF4472 PF14739.6 ELR16434.1 - 0.042 14.6 1.9 0.054 14.2 1.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4472) DivIVA PF05103.13 ELR16434.1 - 0.056 13.5 3.0 0.076 13.1 3.0 1.2 1 0 0 1 1 1 0 DivIVA protein DUF724 PF05266.14 ELR16434.1 - 0.059 13.2 0.6 0.07 13.0 0.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF724) TPR_MLP1_2 PF07926.12 ELR16434.1 - 0.062 13.4 4.9 0.088 12.9 4.9 1.3 1 0 0 1 1 1 0 TPR/MLP1/MLP2-like protein EzrA PF06160.12 ELR16434.1 - 0.073 11.2 1.1 0.083 11.1 1.1 1.0 1 0 0 1 1 1 0 Septation ring formation regulator, EzrA DUF4407 PF14362.6 ELR16434.1 - 0.078 12.3 1.3 0.089 12.1 1.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Rbsn PF11464.8 ELR16434.1 - 0.082 12.7 1.6 17 5.3 0.3 2.9 1 1 3 4 4 4 0 Rabenosyn Rab binding domain Med9 PF07544.13 ELR16434.1 - 0.087 12.9 0.6 0.14 12.3 0.6 1.4 1 0 0 1 1 1 0 RNA polymerase II transcription mediator complex subunit 9 DUF4972 PF16342.5 ELR16434.1 - 0.087 12.5 0.8 0.21 11.3 0.8 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4972) AATF-Che1 PF13339.6 ELR16434.1 - 0.089 13.5 0.8 0.1 13.3 0.8 1.2 1 0 0 1 1 1 0 Apoptosis antagonizing transcription factor YscO PF07321.12 ELR16434.1 - 0.094 12.7 6.9 0.46 10.4 3.1 2.0 1 1 1 2 2 2 0 Type III secretion protein YscO Syntaxin-6_N PF09177.11 ELR16434.1 - 0.1 13.2 5.5 0.35 11.5 5.5 1.8 1 1 0 1 1 1 0 Syntaxin 6, N-terminal Mt_ATP-synt_B PF05405.14 ELR16434.1 - 0.1 12.2 2.1 0.13 11.9 2.1 1.1 1 0 0 1 1 1 0 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) EMP24_GP25L PF01105.24 ELR16434.1 - 0.11 12.5 2.9 0.21 11.5 2.9 1.6 1 1 0 1 1 1 0 emp24/gp25L/p24 family/GOLD Fusion_gly PF00523.18 ELR16434.1 - 0.13 10.5 0.2 0.15 10.2 0.2 1.1 1 0 0 1 1 1 0 Fusion glycoprotein F0 WD40_alt PF14077.6 ELR16434.1 - 0.18 11.7 4.7 7 6.6 0.1 3.2 1 1 1 2 2 2 0 Alternative WD40 repeat motif DUF4094 PF13334.6 ELR16434.1 - 0.2 12.1 2.7 6.4 7.3 2.7 2.2 1 1 0 1 1 1 0 Domain of unknown function (DUF4094) GAS PF13851.6 ELR16434.1 - 0.23 10.8 3.0 0.28 10.5 3.0 1.1 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding OEP PF02321.18 ELR16434.1 - 0.23 11.2 3.2 0.29 10.9 3.2 1.1 1 0 0 1 1 1 0 Outer membrane efflux protein USP8_interact PF08941.10 ELR16434.1 - 0.26 11.1 1.3 0.33 10.8 1.3 1.2 1 0 0 1 1 1 0 USP8 interacting Sas10_Utp3 PF04000.15 ELR16434.1 - 0.74 10.5 3.9 22 5.7 3.9 2.2 1 1 0 1 1 1 0 Sas10/Utp3/C1D family DUF1192 PF06698.11 ELR16434.1 - 1 9.5 4.6 9.9 6.3 0.5 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1192) RasGEF PF00617.19 ELR16435.1 - 3e-49 167.6 0.8 7.7e-49 166.3 0.8 1.8 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 ELR16435.1 - 3.6e-20 72.2 2.7 5e-20 71.7 0.5 2.3 1 1 1 2 2 2 1 RasGEF N-terminal motif Potyvirid-P3 PF13608.6 ELR16435.1 - 0.00013 21.1 0.3 0.00023 20.4 0.3 1.3 1 0 0 1 1 1 1 Protein P3 of Potyviral polyprotein BSD PF03909.17 ELR16435.1 - 0.056 13.4 1.1 0.2 11.7 0.0 2.5 3 0 0 3 3 3 0 BSD domain HATPase_c PF02518.26 ELR16436.1 - 2.5e-27 95.6 0.1 5.1e-27 94.6 0.1 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 ELR16436.1 - 8.4e-23 80.7 0.0 1.6e-22 79.7 0.0 1.5 1 0 0 1 1 1 1 Response regulator receiver domain HisKA PF00512.25 ELR16436.1 - 1.4e-12 47.5 0.1 8.3e-12 45.0 0.0 2.5 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain PAS_9 PF13426.7 ELR16436.1 - 5.5e-12 45.9 0.0 5.9e-10 39.3 0.0 2.9 2 0 0 2 2 2 1 PAS domain PAS_4 PF08448.10 ELR16436.1 - 3.3e-09 37.0 1.5 0.00015 22.0 0.0 3.5 3 1 0 3 3 3 2 PAS fold PAS PF00989.25 ELR16436.1 - 2.2e-05 24.4 0.0 0.0033 17.4 0.0 3.5 4 0 0 4 4 4 1 PAS fold HATPase_c_3 PF13589.6 ELR16436.1 - 0.00089 19.1 0.0 0.0025 17.7 0.0 1.8 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase PAS_8 PF13188.7 ELR16436.1 - 0.022 14.8 0.0 0.44 10.6 0.0 2.6 2 0 0 2 2 2 0 PAS domain Dicty_REP PF05086.12 ELR16436.1 - 0.67 7.9 6.5 1.3 6.9 6.5 1.4 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein AMP-binding PF00501.28 ELR16437.1 - 4.5e-94 315.4 0.0 6.9e-94 314.8 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 ELR16437.1 - 0.0043 18.0 0.0 0.055 14.5 0.0 2.8 1 1 0 1 1 1 1 AMP-binding enzyme C-terminal domain DUF4262 PF14081.6 ELR16437.1 - 0.066 13.4 0.0 0.16 12.1 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4262) SPO22 PF08631.10 ELR16439.1 - 2.6e-08 33.7 15.8 0.001 18.6 0.4 4.6 3 2 1 4 4 4 3 Meiosis protein SPO22/ZIP4 like TPR_12 PF13424.6 ELR16439.1 - 2e-07 31.2 13.4 0.019 15.2 0.2 5.7 4 1 1 5 5 5 3 Tetratricopeptide repeat ANAPC3 PF12895.7 ELR16439.1 - 2.8e-05 24.3 10.0 0.016 15.4 1.2 4.1 4 1 0 4 4 3 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_1 PF00515.28 ELR16439.1 - 0.00035 20.3 8.7 0.034 14.0 0.2 4.2 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.17 ELR16439.1 - 0.0029 17.6 20.7 0.018 15.1 0.3 5.6 5 2 1 6 6 6 2 Tetratricopeptide repeat TPR_8 PF13181.6 ELR16439.1 - 0.0031 17.6 12.9 0.11 12.7 0.4 5.0 4 1 1 5 5 4 1 Tetratricopeptide repeat TPR_14 PF13428.6 ELR16439.1 - 0.0079 16.9 9.3 0.089 13.7 0.3 4.9 4 2 1 5 5 4 1 Tetratricopeptide repeat TPR_6 PF13174.6 ELR16439.1 - 0.018 15.7 3.5 0.82 10.4 0.0 4.1 4 0 0 4 4 3 0 Tetratricopeptide repeat TPR_19 PF14559.6 ELR16439.1 - 0.24 11.9 10.9 0.16 12.5 1.7 3.7 3 1 0 3 3 3 0 Tetratricopeptide repeat DUF2225 PF09986.9 ELR16439.1 - 0.37 10.5 3.5 0.94 9.2 0.1 2.7 3 1 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2225) TPR_16 PF13432.6 ELR16439.1 - 2.3 8.9 13.2 0.77 10.5 0.5 3.8 2 1 4 6 6 5 0 Tetratricopeptide repeat TPR_3 PF07720.12 ELR16439.1 - 5.8 7.0 7.6 3.8 7.6 0.0 3.8 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_10 PF13374.6 ELR16439.1 - 9.3 6.3 11.1 9.9 6.2 0.1 4.5 6 0 0 6 6 6 0 Tetratricopeptide repeat TBP PF00352.21 ELR16441.1 - 3e-68 225.8 0.2 2.5e-33 113.9 0.1 2.1 2 0 0 2 2 2 2 Transcription factor TFIID (or TATA-binding protein, TBP) DUF3378 PF11858.8 ELR16441.1 - 0.0001 22.3 0.0 0.51 10.5 0.0 2.4 2 0 0 2 2 2 2 Domain of unknown function (DUF3378) AA_permease_2 PF13520.6 ELR16443.1 - 1.1e-30 106.9 38.6 2.8e-30 105.5 38.7 1.6 1 1 1 2 2 2 1 Amino acid permease AA_permease PF00324.21 ELR16443.1 - 7.9e-11 41.2 32.5 2e-10 39.9 32.3 1.8 1 1 0 1 1 1 1 Amino acid permease RasGEF PF00617.19 ELR16444.1 - 1.6e-48 165.3 0.1 3.3e-48 164.2 0.1 1.6 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 ELR16444.1 - 1.8e-09 37.8 1.3 9.9e-09 35.4 0.0 2.9 3 0 0 3 3 3 1 RasGEF N-terminal motif PBP PF01161.20 ELR16445.1 - 7.8e-13 48.9 0.4 2e-12 47.6 0.1 1.7 2 0 0 2 2 2 1 Phosphatidylethanolamine-binding protein MscL PF01741.18 ELR16446.1 - 1.7e-21 76.7 0.1 2.2e-21 76.4 0.1 1.1 1 0 0 1 1 1 1 Large-conductance mechanosensitive channel, MscL CM2 PF03021.14 ELR16446.1 - 0.12 12.2 0.0 0.22 11.3 0.0 1.4 1 0 0 1 1 1 0 Influenza C virus M2 protein Bac_globin PF01152.21 ELR16447.1 - 5.5e-13 49.1 0.0 1.1e-12 48.2 0.0 1.5 1 0 0 1 1 1 1 Bacterial-like globin Coilin_N PF15862.5 ELR16447.1 - 2.4e-05 24.2 2.1 2.4e-05 24.2 2.1 1.2 1 0 0 1 1 1 1 Coilin N-terminus GAGA_bind PF06217.12 ELR16447.1 - 0.054 13.8 6.9 0.061 13.6 6.9 1.2 1 0 0 1 1 1 0 GAGA binding protein-like family RR_TM4-6 PF06459.12 ELR16447.1 - 0.1 12.4 8.6 0.12 12.2 7.8 1.5 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 RNA_polI_A34 PF08208.11 ELR16447.1 - 0.2 11.8 25.7 0.28 11.2 25.7 1.2 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 Med19 PF10278.9 ELR16447.1 - 0.35 10.8 19.2 0.56 10.1 19.2 1.3 1 0 0 1 1 1 0 Mediator of RNA pol II transcription subunit 19 RNA_pol_Rpc4 PF05132.14 ELR16447.1 - 0.8 10.1 9.6 1.8 9.0 9.2 1.8 2 0 0 2 2 2 0 RNA polymerase III RPC4 Peptidase_S49_N PF08496.10 ELR16447.1 - 1 9.4 15.9 1.8 8.6 14.1 2.0 2 0 0 2 2 2 0 Peptidase family S49 N-terminal Zip PF02535.22 ELR16447.1 - 2.7 7.1 4.9 3.3 6.8 4.9 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter HA2 PF04408.23 ELR16447.1 - 3.8 7.8 5.4 6.2 7.2 5.4 1.4 1 0 0 1 1 1 0 Helicase associated domain (HA2) WD40 PF00400.32 ELR16448.1 - 1.1e-23 83.0 22.1 3.8e-08 33.9 1.1 6.9 6 1 0 6 6 6 5 WD domain, G-beta repeat F-box-like PF12937.7 ELR16448.1 - 4.5e-10 39.3 2.6 8.9e-10 38.3 2.6 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ELR16448.1 - 5.7e-06 26.1 3.3 1.8e-05 24.5 3.3 1.8 1 1 0 1 1 1 1 F-box domain PQQ_3 PF13570.6 ELR16448.1 - 0.00058 20.3 0.0 2 9.0 0.0 4.1 4 0 0 4 4 4 1 PQQ-like domain BBS2_Mid PF14783.6 ELR16448.1 - 0.0016 18.4 0.4 4.5 7.3 0.1 4.0 3 2 0 3 3 3 2 Ciliary BBSome complex subunit 2, middle region ANAPC4_WD40 PF12894.7 ELR16448.1 - 0.0017 18.6 0.0 0.17 12.2 0.0 3.2 2 1 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain zf_UBZ PF18439.1 ELR16448.1 - 0.26 10.9 1.2 0.67 9.6 1.2 1.7 1 0 0 1 1 1 0 Ubiquitin-Binding Zinc Finger RhoGEF PF00621.20 ELR16449.1 - 4.8e-47 160.5 0.4 4.8e-47 160.5 0.4 3.7 3 1 0 3 3 3 1 RhoGEF domain DSPc PF00782.20 ELR16451.1 - 3.2e-29 101.4 0.0 3.8e-29 101.2 0.0 1.1 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 ELR16451.1 - 0.00047 19.8 0.0 0.00059 19.5 0.0 1.1 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Init_tRNA_PT PF04179.12 ELR16451.1 - 0.00067 19.9 0.0 0.00095 19.5 0.0 1.2 1 0 0 1 1 1 1 Rit1 DUSP-like domain PTPlike_phytase PF14566.6 ELR16451.1 - 0.019 15.1 0.0 0.027 14.6 0.0 1.3 1 0 0 1 1 1 0 Inositol hexakisphosphate CDKN3 PF05706.12 ELR16451.1 - 0.056 13.1 0.0 0.13 11.9 0.0 1.6 1 1 0 1 1 1 0 Cyclin-dependent kinase inhibitor 3 (CDKN3) Y_phosphatase2 PF03162.13 ELR16451.1 - 0.12 12.0 0.0 0.14 11.7 0.0 1.2 1 0 0 1 1 1 0 Tyrosine phosphatase family Myotub-related PF06602.14 ELR16451.1 - 0.15 10.9 0.0 0.21 10.5 0.0 1.1 1 0 0 1 1 1 0 Myotubularin-like phosphatase domain Ank_2 PF12796.7 ELR16452.1 - 1.3e-33 115.4 0.0 6.1e-12 46.0 0.0 5.2 3 3 2 5 5 5 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ELR16452.1 - 7.7e-31 106.1 0.0 8.6e-07 29.4 0.0 8.3 6 2 1 8 8 8 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 ELR16452.1 - 4.5e-29 97.3 0.0 5.6e-05 23.2 0.0 10.5 12 0 0 12 12 12 5 Ankyrin repeat Ank PF00023.30 ELR16452.1 - 4.7e-21 74.2 2.9 1.4e-05 25.3 0.1 8.5 10 0 0 10 10 10 4 Ankyrin repeat Ank_5 PF13857.6 ELR16452.1 - 4.7e-21 74.6 0.5 1.7e-05 25.0 0.0 6.0 6 1 1 7 7 7 4 Ankyrin repeats (many copies) F-box-like PF12937.7 ELR16452.1 - 5.5e-07 29.4 0.0 1.2e-06 28.3 0.0 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ELR16452.1 - 0.076 12.9 0.0 0.15 12.0 0.0 1.5 1 0 0 1 1 1 0 F-box domain Arm PF00514.23 ELR16453.1 - 4.3e-10 39.3 4.2 0.021 14.9 0.0 5.6 6 0 0 6 6 6 3 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.6 ELR16453.1 - 2.4e-05 24.6 0.9 0.31 11.5 0.1 3.7 2 1 0 3 3 3 2 HEAT repeats Arm_2 PF04826.13 ELR16453.1 - 5.2e-05 22.8 4.8 0.0079 15.7 0.5 2.1 2 0 0 2 2 2 2 Armadillo-like HEAT_EZ PF13513.6 ELR16453.1 - 0.00077 19.9 0.3 1.6 9.3 0.0 4.7 5 1 1 6 6 6 1 HEAT-like repeat Cnd1 PF12717.7 ELR16453.1 - 0.0023 18.0 1.6 0.17 11.9 0.1 2.3 2 0 0 2 2 2 2 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.22 ELR16453.1 - 0.007 16.5 0.4 8.2 7.0 0.0 5.2 7 1 1 8 8 8 1 HEAT repeat Vac14_Fab1_bd PF12755.7 ELR16453.1 - 0.0079 16.8 0.5 2.4 8.8 0.0 3.5 2 1 2 4 4 4 1 Vacuolar 14 Fab1-binding region Atx10homo_assoc PF09759.9 ELR16453.1 - 0.07 13.2 2.9 0.47 10.5 0.2 3.2 2 1 1 4 4 4 0 Spinocerebellar ataxia type 10 protein domain VCPO_N PF17897.1 ELR16453.1 - 0.17 11.7 0.8 6.2 6.6 0.0 2.6 2 1 0 2 2 2 0 Vanadium chloroperoxidase N-terminal domain DUF3361 PF11841.8 ELR16453.1 - 0.44 10.5 4.9 6.9 6.6 0.3 2.9 1 1 0 2 2 2 0 Domain of unknown function (DUF3361) Aldedh PF00171.22 ELR16454.1 - 1.6e-20 73.1 0.1 1.7e-20 73.0 0.1 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Aldedh PF00171.22 ELR16457.1 - 2.3e-07 29.7 0.1 2.5e-07 29.6 0.1 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DUF4929 PF16283.5 ELR16457.1 - 0.037 13.0 0.0 0.037 13.0 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4929) DUF4175 PF13779.6 ELR16460.1 - 0.31 8.9 0.6 0.34 8.8 0.6 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) WD40 PF00400.32 ELR16463.1 - 0.0002 22.1 0.7 1.1 10.3 0.1 3.5 3 1 0 3 3 3 2 WD domain, G-beta repeat RRM_1 PF00076.22 ELR16464.1 - 4.1e-12 45.7 0.0 4.7e-12 45.5 0.0 1.1 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.22 ELR16465.1 - 2.1e-39 133.1 0.0 3.6e-12 45.9 0.0 4.2 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 ELR16465.1 - 0.0024 17.7 0.0 0.052 13.4 0.0 2.9 4 0 0 4 4 4 1 Occluded RNA-recognition motif Nup35_RRM_2 PF14605.6 ELR16465.1 - 0.036 14.1 0.0 0.09 12.8 0.0 1.7 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif OB_RNB PF08206.11 ELR16465.1 - 0.05 13.3 0.0 1.5 8.6 0.0 2.3 2 0 0 2 2 2 0 Ribonuclease B OB domain RRM_7 PF16367.5 ELR16465.1 - 0.14 12.3 0.1 16 5.7 0.0 2.9 3 1 0 3 3 3 0 RNA recognition motif Ank PF00023.30 ELR16466.1 - 6.5e-11 42.2 0.0 9.9e-05 22.6 0.0 3.0 3 0 0 3 3 3 2 Ankyrin repeat Ank_2 PF12796.7 ELR16466.1 - 1.8e-10 41.3 0.0 6.4e-05 23.5 0.0 2.3 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 ELR16466.1 - 2.5e-10 39.7 0.0 0.0007 19.9 0.0 2.7 2 0 0 2 2 2 2 Ankyrin repeat Ank_4 PF13637.6 ELR16466.1 - 3.8e-09 36.9 0.0 8.8e-05 23.0 0.0 3.4 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 ELR16466.1 - 1.6e-07 31.4 0.0 0.00093 19.4 0.0 2.4 2 0 0 2 2 2 2 Ankyrin repeats (many copies) DUF1290 PF06947.12 ELR16466.1 - 0.048 13.8 0.3 0.11 12.6 0.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1290) EF-hand_7 PF13499.6 ELR16467.1 - 9.2e-06 26.0 5.4 0.0036 17.7 1.0 2.3 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_1 PF00036.32 ELR16467.1 - 4.4e-05 22.7 3.5 0.00025 20.3 0.2 2.6 2 0 0 2 2 2 1 EF hand EF-hand_8 PF13833.6 ELR16467.1 - 0.001 18.8 0.9 0.0028 17.5 0.1 2.0 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.6 ELR16467.1 - 0.002 17.9 1.9 0.0024 17.6 0.2 2.0 2 0 0 2 2 2 1 EF-hand domain EF-hand_5 PF13202.6 ELR16467.1 - 0.026 14.0 0.6 0.026 14.0 0.6 1.9 2 0 0 2 2 2 0 EF hand WD40 PF00400.32 ELR16468.1 - 4.3e-09 36.8 3.5 0.00029 21.6 0.2 3.6 3 1 0 3 3 3 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ELR16468.1 - 2.7e-08 34.0 0.0 1.8e-07 31.4 0.0 1.9 1 1 1 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain Cytochrom_D1 PF02239.16 ELR16468.1 - 0.0091 14.6 0.0 0.011 14.3 0.0 1.1 1 0 0 1 1 1 1 Cytochrome D1 heme domain PQQ_3 PF13570.6 ELR16468.1 - 0.0097 16.4 1.5 0.23 12.0 0.9 2.3 2 1 0 2 2 2 1 PQQ-like domain WD40_like PF17005.5 ELR16468.1 - 0.041 13.2 0.0 0.052 12.9 0.0 1.1 1 0 0 1 1 1 0 WD40-like domain Utp8 PF10395.9 ELR16468.1 - 0.074 11.5 0.0 0.075 11.5 0.0 1.0 1 0 0 1 1 1 0 Utp8 family HRXXH PF13933.6 ELR16468.1 - 0.12 11.9 0.0 0.21 11.1 0.0 1.3 1 1 0 1 1 1 0 Putative peptidase family WD40 PF00400.32 ELR16469.1 - 0.0055 17.5 0.2 0.63 11.0 0.0 3.5 3 0 0 3 3 3 1 WD domain, G-beta repeat SOG2 PF10428.9 ELR16469.1 - 6.4 5.9 5.9 8.3 5.5 5.9 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein RhoGEF PF00621.20 ELR16470.1 - 1.3e-44 152.6 0.1 3.1e-44 151.4 0.1 1.7 1 0 0 1 1 1 1 RhoGEF domain SH3_1 PF00018.28 ELR16470.1 - 1.4e-11 43.8 0.0 2.8e-11 42.8 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 ELR16470.1 - 1.9e-11 43.6 0.1 6.3e-11 42.0 0.1 1.9 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 ELR16470.1 - 5.5e-11 42.0 0.1 1.3e-10 40.8 0.1 1.7 1 0 0 1 1 1 1 Variant SH3 domain IQ_SEC7_PH PF16453.5 ELR16470.1 - 0.0031 17.5 0.1 0.011 15.7 0.0 1.9 2 0 0 2 2 2 1 PH domain IQ PF00612.27 ELR16470.1 - 0.0044 16.7 2.4 0.012 15.3 2.4 1.8 1 0 0 1 1 1 1 IQ calmodulin-binding motif STI1 PF17830.1 ELR16470.1 - 0.18 11.8 0.1 1.1 9.3 0.3 2.1 2 0 0 2 2 2 0 STI1 domain Pkinase PF00069.25 ELR16471.1 - 1.1e-74 251.1 0.1 1.7e-74 250.5 0.1 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR16471.1 - 1.8e-38 132.3 0.0 2.9e-38 131.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase PAS PF00989.25 ELR16471.1 - 1.1e-20 73.6 0.0 3.1e-07 30.4 0.0 3.9 4 0 0 4 4 4 3 PAS fold PAS_9 PF13426.7 ELR16471.1 - 2.3e-20 72.8 0.1 5.1e-07 29.9 0.0 4.5 4 0 0 4 4 4 4 PAS domain Kinase-like PF14531.6 ELR16471.1 - 8.2e-10 38.5 0.0 1.3e-09 37.9 0.0 1.2 1 0 0 1 1 1 1 Kinase-like PAS_4 PF08448.10 ELR16471.1 - 3.3e-09 37.0 0.0 0.0052 17.0 0.0 4.0 4 0 0 4 4 4 2 PAS fold PAS_3 PF08447.12 ELR16471.1 - 3e-07 30.6 0.0 0.092 13.1 0.0 4.4 4 0 0 4 4 4 2 PAS fold Kdo PF06293.14 ELR16471.1 - 5.3e-05 22.7 0.5 5.3e-05 22.7 0.5 1.6 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family PAS_8 PF13188.7 ELR16471.1 - 0.00037 20.4 0.0 0.086 12.9 0.0 3.2 3 0 0 3 3 3 1 PAS domain Haspin_kinase PF12330.8 ELR16471.1 - 0.0048 15.9 0.3 0.008 15.2 0.3 1.2 1 0 0 1 1 1 1 Haspin like kinase domain DUF5625 PF18539.1 ELR16471.1 - 0.011 16.0 0.3 7.6 6.8 0.0 3.3 3 1 0 3 3 3 0 Domain of unknown function (DUF5625) RIO1 PF01163.22 ELR16471.1 - 0.029 14.0 0.3 0.057 13.0 0.3 1.4 1 0 0 1 1 1 0 RIO1 family APH PF01636.23 ELR16471.1 - 0.069 13.1 0.1 0.23 11.4 0.0 1.6 1 1 1 2 2 2 0 Phosphotransferase enzyme family Macoilin PF09726.9 ELR16471.1 - 2.3 6.7 9.3 4.2 5.8 9.3 1.3 1 0 0 1 1 1 0 Macoilin family LAMTOR PF15454.6 ELR16473.1 - 2.2e-06 28.2 0.3 7.8e-06 26.4 0.1 1.8 2 0 0 2 2 2 1 Late endosomal/lysosomal adaptor and MAPK and MTOR activator SpoU_methylase PF00588.19 ELR16474.1 - 3.4e-27 95.3 0.0 6.7e-27 94.4 0.0 1.5 1 0 0 1 1 1 1 SpoU rRNA Methylase family SLX9 PF15341.6 ELR16474.1 - 0.7 10.3 8.6 1.1 9.6 1.5 3.3 3 1 0 3 3 3 0 Ribosome biogenesis protein SLX9 SSF PF00474.17 ELR16475.1 - 7.5e-15 54.7 39.6 1.3e-14 53.9 39.6 1.4 1 0 0 1 1 1 1 Sodium:solute symporter family DUF3882 PF07066.11 ELR16475.1 - 0.015 15.4 0.0 0.028 14.5 0.0 1.4 1 0 0 1 1 1 0 Lactococcus phage M3 protein DUF1292 PF06949.11 ELR16475.1 - 0.31 12.0 4.4 0.6 11.1 4.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1292) UT PF03253.14 ELR16476.1 - 2.1e-66 224.0 34.3 3.7e-66 223.2 34.3 1.4 1 1 0 1 1 1 1 Urea transporter ABC2_membrane_5 PF13346.6 ELR16477.1 - 0.05 13.2 1.4 0.63 9.6 0.1 2.2 2 0 0 2 2 2 0 ABC-2 family transporter protein Cation_efflux PF01545.21 ELR16477.1 - 0.052 13.3 3.5 1.7 8.3 3.5 2.1 1 1 0 1 1 1 0 Cation efflux family SPC25 PF06703.11 ELR16477.1 - 0.2 11.4 0.3 0.92 9.3 0.1 2.1 2 0 0 2 2 2 0 Microsomal signal peptidase 25 kDa subunit (SPC25) Peptidase_U4 PF03419.13 ELR16477.1 - 0.87 8.8 3.0 13 5.0 0.3 2.3 2 0 0 2 2 2 0 Sporulation factor SpoIIGA PAP2 PF01569.21 ELR16477.1 - 3.3 7.5 10.2 17 5.1 8.3 3.0 1 1 0 1 1 1 0 PAP2 superfamily FERM_M PF00373.18 ELR16478.1 - 1.3e-20 73.9 0.0 2.5e-20 73.1 0.0 1.5 1 0 0 1 1 1 1 FERM central domain FERM_N PF09379.10 ELR16478.1 - 0.0076 16.2 0.0 0.02 14.8 0.0 1.7 1 0 0 1 1 1 1 FERM N-terminal domain YcxB PF14317.6 ELR16478.1 - 0.1 12.3 0.2 0.21 11.3 0.2 1.5 1 0 0 1 1 1 0 YcxB-like protein PhoLip_ATPase_C PF16212.5 ELR16479.1 - 1.4e-73 247.7 25.4 1.4e-73 247.7 25.4 2.1 2 0 0 2 2 2 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 ELR16479.1 - 1.3e-26 92.0 0.3 3.3e-26 90.8 0.3 1.7 1 0 0 1 1 1 1 Phospholipid-translocating ATPase N-terminal Cation_ATPase PF13246.6 ELR16479.1 - 8.4e-13 48.2 0.0 4.5e-12 45.9 0.0 2.1 2 0 0 2 2 2 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 ELR16479.1 - 2.2e-09 37.9 1.8 0.00019 21.8 0.6 3.6 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.20 ELR16479.1 - 4.1e-09 36.2 0.0 1.8e-08 34.1 0.0 2.1 1 1 0 1 1 1 1 E1-E2 ATPase Hydrolase_3 PF08282.12 ELR16479.1 - 0.0047 16.7 0.1 0.016 15.0 0.1 1.9 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase CPSase_L_D2 PF02786.17 ELR16480.1 - 3.1e-79 265.4 0.2 5.6e-79 264.5 0.2 1.5 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain PYC_OADA PF02436.18 ELR16480.1 - 3.3e-62 209.8 0.0 6e-62 208.9 0.0 1.5 1 0 0 1 1 1 1 Conserved carboxylase domain Biotin_carb_N PF00289.22 ELR16480.1 - 1e-34 119.4 0.0 2.8e-34 118.0 0.0 1.8 1 0 0 1 1 1 1 Biotin carboxylase, N-terminal domain Biotin_carb_C PF02785.19 ELR16480.1 - 3.1e-32 110.9 0.0 8.7e-32 109.4 0.0 1.8 1 0 0 1 1 1 1 Biotin carboxylase C-terminal domain HMGL-like PF00682.19 ELR16480.1 - 1.5e-30 106.6 0.0 2.6e-30 105.9 0.0 1.3 1 0 0 1 1 1 1 HMGL-like Biotin_lipoyl PF00364.22 ELR16480.1 - 7.2e-18 64.2 4.0 1.8e-17 63.0 4.0 1.7 1 0 0 1 1 1 1 Biotin-requiring enzyme Biotin_lipoyl_2 PF13533.6 ELR16480.1 - 1e-11 44.4 1.3 4e-06 26.5 0.2 2.5 1 1 1 2 2 2 2 Biotin-lipoyl like Dala_Dala_lig_C PF07478.13 ELR16480.1 - 2.9e-10 40.0 0.0 8.1e-10 38.6 0.0 1.7 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus ATP-grasp PF02222.22 ELR16480.1 - 1.6e-08 34.3 0.1 4.2e-08 33.0 0.1 1.6 1 0 0 1 1 1 1 ATP-grasp domain ATP-grasp_3 PF02655.14 ELR16480.1 - 0.00096 19.2 0.0 0.0026 17.8 0.0 1.8 1 0 0 1 1 1 1 ATP-grasp domain NQRA PF05896.11 ELR16480.1 - 0.0012 18.3 0.2 0.0024 17.3 0.2 1.4 1 0 0 1 1 1 1 Na(+)-translocating NADH-quinone reductase subunit A (NQRA) ATP-grasp_4 PF13535.6 ELR16480.1 - 0.0055 16.3 0.0 0.012 15.2 0.0 1.6 1 0 0 1 1 1 1 ATP-grasp domain HlyD_D23 PF16576.5 ELR16480.1 - 0.014 14.6 0.1 0.52 9.5 0.0 2.3 1 1 1 2 2 2 0 Barrel-sandwich domain of CusB or HlyD membrane-fusion HlyD_3 PF13437.6 ELR16480.1 - 0.016 15.9 0.5 3.8 8.2 0.0 3.0 3 0 0 3 3 2 0 HlyD family secretion protein RnfC_N PF13375.6 ELR16480.1 - 0.097 12.6 0.5 0.34 10.9 0.1 2.1 2 0 0 2 2 2 0 RnfC Barrel sandwich hybrid domain PTS_EIIA_1 PF00358.20 ELR16480.1 - 0.2 11.4 1.9 6.8 6.5 0.1 3.3 2 1 1 3 3 3 0 phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1 Abhydrolase_3 PF07859.13 ELR16481.1 - 1.3e-13 51.3 5.9 1.5e-13 51.2 0.1 2.2 1 1 1 2 2 2 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 ELR16481.1 - 4.2e-05 23.1 0.0 0.0007 19.1 0.0 2.1 2 0 0 2 2 2 1 Prolyl oligopeptidase family Say1_Mug180 PF10340.9 ELR16481.1 - 7.5e-05 21.8 0.1 0.084 11.7 0.0 2.1 1 1 1 2 2 2 2 Steryl acetyl hydrolase COesterase PF00135.28 ELR16481.1 - 0.19 10.6 0.1 2.2 7.0 0.0 2.0 1 1 1 2 2 2 0 Carboxylesterase family WD40 PF00400.32 ELR16482.1 - 8.2e-28 96.1 23.1 5.3e-05 23.9 1.6 6.9 6 0 0 6 6 6 6 WD domain, G-beta repeat F-box-like PF12937.7 ELR16482.1 - 9.9e-08 31.8 0.0 1.9e-07 30.8 0.0 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ELR16482.1 - 1.5e-07 31.1 0.0 3e-07 30.1 0.0 1.5 1 0 0 1 1 1 1 F-box domain ubiquitin PF00240.23 ELR16482.1 - 2.3e-07 30.5 0.0 0.0015 18.2 0.0 2.8 2 0 0 2 2 2 2 Ubiquitin family Nup160 PF11715.8 ELR16482.1 - 0.00065 18.5 12.4 2 7.0 1.8 5.4 2 2 4 6 6 6 3 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ELR16482.1 - 0.0025 18.1 4.2 0.12 12.7 0.2 4.0 2 1 2 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain AAA_11 PF13086.6 ELR16482.1 - 5.3 6.7 7.4 0.63 9.8 3.3 1.5 2 0 0 2 2 2 0 AAA domain Galactosyl_T PF01762.21 ELR16483.1 - 2.4e-16 60.1 0.0 2.8e-16 59.9 0.0 1.1 1 0 0 1 1 1 1 Galactosyltransferase Fringe PF02434.16 ELR16483.1 - 0.00027 20.5 0.0 0.00034 20.1 0.0 1.1 1 0 0 1 1 1 1 Fringe-like Dam PF05869.11 ELR16484.1 - 0.0039 16.8 0.0 0.0044 16.6 0.0 1.2 1 0 0 1 1 1 1 DNA N-6-adenine-methyltransferase (Dam) RVT_1 PF00078.27 ELR16485.1 - 2.2e-07 30.6 0.1 2.4e-07 30.5 0.1 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) L27_2 PF09045.10 ELR16485.1 - 0.036 14.0 0.1 0.062 13.3 0.1 1.3 1 0 0 1 1 1 0 L27_2 Cyclin_N PF00134.23 ELR16485.1 - 0.052 13.3 0.1 1.7 8.4 0.1 2.0 1 1 0 1 1 1 0 Cyclin, N-terminal domain Response_reg PF00072.24 ELR16487.1 - 6.8e-10 39.1 0.0 1e-09 38.5 0.0 1.3 1 1 0 1 1 1 1 Response regulator receiver domain Dam PF05869.11 ELR16488.1 - 0.013 15.1 0.1 0.022 14.3 0.1 1.4 1 0 0 1 1 1 0 DNA N-6-adenine-methyltransferase (Dam) UCH PF00443.29 ELR16489.1 - 5e-42 144.2 3.1 8.4e-42 143.4 3.1 1.4 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 ELR16489.1 - 1e-14 54.9 9.1 4.7e-13 49.4 9.1 2.9 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase DUSP PF06337.12 ELR16489.1 - 1e-08 35.7 4.5 0.00028 21.5 0.0 4.4 4 1 0 4 4 4 2 DUSP domain ubiquitin PF00240.23 ELR16489.1 - 1.3e-07 31.3 0.1 5.6e-07 29.2 0.1 2.2 1 0 0 1 1 1 1 Ubiquitin family APG12 PF04110.13 ELR16489.1 - 0.03 14.7 0.5 2.1 8.8 0.1 2.6 2 0 0 2 2 2 0 Ubiquitin-like autophagy protein Apg12 Vps36-NZF-N PF16988.5 ELR16489.1 - 0.056 12.8 0.0 0.21 11.0 0.0 2.0 1 0 0 1 1 1 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain CsbD PF05532.12 ELR16489.1 - 0.22 11.5 2.2 0.53 10.2 2.2 1.7 1 0 0 1 1 1 0 CsbD-like zf-RanBP PF00641.18 ELR16489.1 - 0.45 9.9 5.2 0.37 10.1 0.1 2.9 3 0 0 3 3 3 0 Zn-finger in Ran binding protein and others zf-Sec23_Sec24 PF04810.15 ELR16489.1 - 0.5 10.5 4.8 11 6.2 0.1 2.7 2 0 0 2 2 2 0 Sec23/Sec24 zinc finger GATA PF00320.27 ELR16490.1 - 1.2e-15 56.8 1.5 2e-15 56.1 1.5 1.4 1 0 0 1 1 1 1 GATA zinc finger UBA PF00627.31 ELR16491.1 - 2.5e-07 30.5 0.1 0.04 13.8 0.0 3.0 3 0 0 3 3 3 2 UBA/TS-N domain HBS1_N PF08938.10 ELR16491.1 - 0.0086 16.4 0.3 2.5 8.5 0.0 3.2 1 1 2 3 3 3 1 HBS1 N-terminus 3-HAO PF06052.12 ELR16492.1 - 4.6e-50 169.2 0.0 4.9e-50 169.1 0.0 1.0 1 0 0 1 1 1 1 3-hydroxyanthranilic acid dioxygenase Cupin_2 PF07883.11 ELR16492.1 - 1.4e-05 24.7 0.2 2.1e-05 24.1 0.2 1.3 1 0 0 1 1 1 1 Cupin domain DNA_pol_A_exo1 PF01612.20 ELR16493.1 - 9.6e-24 84.0 0.1 4.9e-23 81.7 0.0 1.9 2 0 0 2 2 2 1 3'-5' exonuclease Med3 PF11593.8 ELR16493.1 - 2 7.5 6.2 2.8 7.0 6.2 1.2 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal TraB PF01963.17 ELR16494.1 - 2.1e-09 37.7 0.0 3.1e-09 37.1 0.0 1.3 1 0 0 1 1 1 1 TraB family VASP_tetra PF08776.11 ELR16494.1 - 0.25 11.0 2.0 0.55 9.8 2.0 1.6 1 0 0 1 1 1 0 VASP tetramerisation domain DNA_pol_A_exo1 PF01612.20 ELR16495.1 - 0.0017 18.1 0.3 0.0019 17.9 0.3 1.1 1 0 0 1 1 1 1 3'-5' exonuclease TraB PF01963.17 ELR16496.1 - 1.5e-10 41.4 0.0 1.5e-10 41.4 0.0 2.8 1 1 1 2 2 2 2 TraB family Histone PF00125.24 ELR16498.1 - 6.4e-13 49.2 0.5 7.2e-13 49.0 0.5 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 ELR16498.1 - 0.0004 20.6 0.4 0.00056 20.1 0.4 1.2 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone PBSX_XtrA PF17356.2 ELR16499.1 - 0.047 13.6 0.1 0.094 12.6 0.1 1.5 1 0 0 1 1 1 0 Phage-like element PBSX protein XtrA Aldo_ket_red PF00248.21 ELR16500.1 - 1.6e-19 70.2 0.0 2.1e-19 69.9 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family Cpn60_TCP1 PF00118.24 ELR16501.1 - 0.00036 19.3 0.6 0.03 13.0 0.2 2.0 1 1 1 2 2 2 2 TCP-1/cpn60 chaperonin family SH3_9 PF14604.6 ELR16502.1 - 7.3e-10 38.6 0.1 9.3e-10 38.2 0.1 1.1 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 ELR16502.1 - 6e-07 29.0 0.0 7.8e-07 28.6 0.0 1.2 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 ELR16502.1 - 2.4e-05 23.9 0.1 3.2e-05 23.5 0.1 1.2 1 0 0 1 1 1 1 Variant SH3 domain Toprim_4 PF13662.6 ELR16502.1 - 0.092 13.2 0.0 0.11 12.9 0.0 1.1 1 0 0 1 1 1 0 Toprim domain ubiquitin PF00240.23 ELR16503.1 - 7.6e-10 38.4 0.3 8.4e-08 31.9 0.2 2.5 1 1 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 ELR16503.1 - 0.036 13.9 0.1 0.073 12.9 0.1 1.6 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like Thioredoxin_15 PF18403.1 ELR16503.1 - 0.044 13.7 0.0 0.058 13.3 0.0 1.2 1 0 0 1 1 1 0 Thioredoxin-like domain Tmemb_cc2 PF10267.9 ELR16504.1 - 0.0032 16.7 15.4 0.006 15.8 13.2 2.1 1 1 1 2 2 2 1 Predicted transmembrane and coiled-coil 2 protein Paramyx_P_V_C PF03210.13 ELR16504.1 - 0.0063 16.3 1.1 0.074 12.8 0.7 2.2 1 1 1 2 2 2 1 Paramyxovirus P/V phosphoprotein C-terminal Filament PF00038.21 ELR16504.1 - 0.029 14.0 18.2 0.039 13.5 17.6 1.5 1 1 0 1 1 1 0 Intermediate filament protein TMPIT PF07851.13 ELR16504.1 - 0.048 12.9 7.6 0.071 12.4 7.6 1.2 1 0 0 1 1 1 0 TMPIT-like protein DUF4618 PF15397.6 ELR16504.1 - 0.058 12.8 16.0 0.2 11.0 8.8 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4618) YbaB_DNA_bd PF02575.16 ELR16504.1 - 0.085 13.1 4.6 0.29 11.4 4.6 1.9 1 1 0 1 1 1 0 YbaB/EbfC DNA-binding family Aminotran_3 PF00202.21 ELR16504.1 - 0.11 11.2 0.9 0.15 10.7 0.9 1.1 1 0 0 1 1 1 0 Aminotransferase class-III Spo0A_C PF08769.11 ELR16504.1 - 0.11 12.6 1.1 0.56 10.3 0.0 2.6 3 0 0 3 3 3 0 Sporulation initiation factor Spo0A C terminal DUF4407 PF14362.6 ELR16504.1 - 0.13 11.6 2.2 0.18 11.1 2.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF4874 PF16173.5 ELR16504.1 - 0.18 11.5 3.4 0.35 10.5 3.4 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4874) Macoilin PF09726.9 ELR16504.1 - 0.18 10.3 12.3 0.24 9.9 12.3 1.2 1 0 0 1 1 1 0 Macoilin family Cep57_CLD PF14073.6 ELR16504.1 - 0.28 11.2 18.0 2.1 8.3 17.8 2.2 1 1 0 1 1 1 0 Centrosome localisation domain of Cep57 Med9 PF07544.13 ELR16504.1 - 0.35 11.0 11.7 0.47 10.6 9.7 2.3 2 1 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 V_ATPase_I PF01496.19 ELR16504.1 - 0.4 8.5 7.0 0.44 8.4 7.0 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Fib_alpha PF08702.10 ELR16504.1 - 0.41 10.8 10.0 0.29 11.3 6.7 2.2 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family Atg14 PF10186.9 ELR16504.1 - 0.57 9.2 9.9 0.87 8.6 9.9 1.3 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF3461 PF11944.8 ELR16504.1 - 0.75 9.9 12.3 0.052 13.7 4.7 2.7 3 1 1 4 4 4 0 Protein of unknown function (DUF3461) OmpH PF03938.14 ELR16504.1 - 1.1 9.7 15.3 1.2 9.5 13.3 2.1 2 1 0 2 2 2 0 Outer membrane protein (OmpH-like) Ax_dynein_light PF10211.9 ELR16504.1 - 1.2 9.0 16.5 0.27 11.1 10.5 2.4 2 0 0 2 2 2 0 Axonemal dynein light chain FlxA PF14282.6 ELR16504.1 - 1.4 8.9 10.0 0.81 9.7 5.9 2.2 2 0 0 2 2 2 0 FlxA-like protein FAP206 PF12018.8 ELR16504.1 - 2.7 7.4 7.1 5 6.5 7.1 1.4 1 0 0 1 1 1 0 Domain of unknown function Phage_lysis PF03245.13 ELR16504.1 - 3.1 7.9 8.6 1.8 8.7 5.3 2.2 1 1 1 2 2 2 0 Bacteriophage Rz lysis protein HIP1_clath_bdg PF16515.5 ELR16504.1 - 4.4 8.0 19.1 11 6.7 16.0 2.6 1 1 1 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Fmp27_WPPW PF10359.9 ELR16504.1 - 4.6 6.0 15.2 1.7 7.4 11.9 1.8 1 1 0 2 2 2 0 RNA pol II promoter Fmp27 protein domain DUF334 PF03904.13 ELR16504.1 - 4.8 6.7 12.6 1.2 8.7 9.6 1.4 2 0 0 2 2 2 0 Domain of unknown function (DUF334) ACCA PF03255.14 ELR16504.1 - 7.5 6.4 12.7 20 5.0 0.3 2.5 1 1 1 2 2 2 0 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit Ras PF00071.22 ELR16507.1 - 2.5e-27 95.4 0.0 3.4e-27 95.0 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR16507.1 - 7.1e-11 42.4 0.0 1.1e-10 41.8 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Catalase-rel PF06628.12 ELR16508.1 - 5.1e-16 58.6 0.1 6.9e-16 58.2 0.1 1.1 1 0 0 1 1 1 1 Catalase-related immune-responsive Catalase PF00199.19 ELR16508.1 - 0.0012 18.0 0.1 0.014 14.6 0.0 2.1 2 0 0 2 2 2 1 Catalase Catalase PF00199.19 ELR16509.1 - 3.8e-156 520.0 0.0 1e-155 518.6 0.0 1.6 2 0 0 2 2 2 1 Catalase Catalase-rel PF06628.12 ELR16509.1 - 2.9e-15 56.2 0.1 6.1e-15 55.2 0.1 1.5 1 0 0 1 1 1 1 Catalase-related immune-responsive Methyltransf_11 PF08241.12 ELR16510.1 - 1.5e-26 92.8 0.0 3.1e-26 91.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ELR16510.1 - 1.1e-23 83.8 0.1 3.4e-23 82.2 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 ELR16510.1 - 5.8e-20 71.6 0.0 8.1e-20 71.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 ELR16510.1 - 9.8e-19 67.6 0.0 1.4e-18 67.1 0.0 1.1 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_23 PF13489.6 ELR16510.1 - 1.7e-15 57.2 0.0 2.4e-15 56.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ELR16510.1 - 4.4e-14 53.0 0.0 9.2e-14 52.0 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 ELR16510.1 - 1.7e-05 24.7 0.0 2.7e-05 24.0 0.0 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) MetW PF07021.12 ELR16510.1 - 2.1e-05 24.2 0.0 3.2e-05 23.6 0.0 1.2 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW TehB PF03848.14 ELR16510.1 - 2.3e-05 23.9 0.0 4.7e-05 22.9 0.0 1.4 1 0 0 1 1 1 1 Tellurite resistance protein TehB DREV PF05219.12 ELR16510.1 - 3e-05 23.3 0.0 4.4e-05 22.7 0.0 1.2 1 0 0 1 1 1 1 DREV methyltransferase Methyltransf_9 PF08003.11 ELR16510.1 - 4.3e-05 22.6 0.0 6.6e-05 22.0 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) CMAS PF02353.20 ELR16510.1 - 0.00011 21.6 0.0 0.00016 21.1 0.0 1.1 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase NodS PF05401.11 ELR16510.1 - 0.00034 20.3 0.1 0.00048 19.8 0.1 1.2 1 0 0 1 1 1 1 Nodulation protein S (NodS) MTS PF05175.14 ELR16510.1 - 0.00059 19.4 0.1 0.00091 18.8 0.1 1.2 1 0 0 1 1 1 1 Methyltransferase small domain UPF0020 PF01170.18 ELR16510.1 - 0.005 16.6 0.0 0.015 15.0 0.1 1.7 2 0 0 2 2 2 1 Putative RNA methylase family UPF0020 RrnaAD PF00398.20 ELR16510.1 - 0.0072 15.4 0.0 0.011 14.8 0.0 1.2 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Methyltransf_PK PF05891.12 ELR16510.1 - 0.01 15.4 0.0 0.015 14.8 0.0 1.2 1 0 0 1 1 1 0 AdoMet dependent proline di-methyltransferase Methyltransf_2 PF00891.18 ELR16510.1 - 0.013 14.8 0.1 0.019 14.2 0.1 1.2 1 0 0 1 1 1 0 O-methyltransferase domain Methyltransf_8 PF05148.15 ELR16510.1 - 0.069 13.0 0.1 0.13 12.1 0.1 1.4 1 1 0 1 1 1 0 Hypothetical methyltransferase Methyltransf_29 PF03141.16 ELR16510.1 - 0.075 11.6 0.0 0.091 11.3 0.0 1.1 1 0 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase Methyltransf_15 PF09445.10 ELR16510.1 - 0.17 11.5 0.0 0.27 10.8 0.0 1.3 1 0 0 1 1 1 0 RNA cap guanine-N2 methyltransferase MIP PF00230.20 ELR16511.1 - 4.1e-11 43.0 4.1 5e-11 42.7 4.1 1.1 1 0 0 1 1 1 1 Major intrinsic protein zf-C3HC4_3 PF13920.6 ELR16512.1 - 3.1e-11 42.9 9.0 5.4e-11 42.2 9.0 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 ELR16512.1 - 3e-06 27.0 8.2 5.1e-06 26.3 8.2 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 TMCO5 PF14992.6 ELR16512.1 - 0.00028 20.6 8.7 0.00035 20.2 8.7 1.2 1 0 0 1 1 1 1 TMCO5 family K-box PF01486.17 ELR16512.1 - 0.0025 17.9 1.9 0.0025 17.9 1.9 2.1 2 0 0 2 2 2 1 K-box region MAD PF05557.13 ELR16512.1 - 0.025 13.0 12.6 0.032 12.6 12.6 1.1 1 0 0 1 1 1 0 Mitotic checkpoint protein MCPsignal PF00015.21 ELR16512.1 - 0.029 14.2 0.8 0.043 13.6 0.8 1.2 1 0 0 1 1 1 0 Methyl-accepting chemotaxis protein (MCP) signalling domain KIAA1430 PF13879.6 ELR16512.1 - 0.1 13.4 4.5 0.25 12.1 1.7 2.2 2 0 0 2 2 2 0 KIAA1430 homologue zf-C3HC4 PF00097.25 ELR16512.1 - 0.18 11.7 10.0 0.81 9.6 10.3 1.9 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) TPR_MLP1_2 PF07926.12 ELR16512.1 - 0.26 11.3 13.4 0.31 11.1 2.5 2.5 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein T3SSipB PF16535.5 ELR16512.1 - 0.29 11.6 3.2 0.41 11.1 3.2 1.3 1 0 0 1 1 1 0 Type III cell invasion protein SipB zf-RING_5 PF14634.6 ELR16512.1 - 0.31 11.0 7.3 0.6 10.1 7.3 1.5 1 0 0 1 1 1 0 zinc-RING finger domain DivIC PF04977.15 ELR16512.1 - 0.35 10.7 11.4 0.047 13.4 3.2 2.2 2 0 0 2 2 2 0 Septum formation initiator MbeD_MobD PF04899.12 ELR16512.1 - 0.38 10.9 6.8 1.1 9.4 0.5 2.4 1 1 1 2 2 2 0 MbeD/MobD like zf-RING_2 PF13639.6 ELR16512.1 - 1 9.7 9.8 2.1 8.7 9.8 1.5 1 0 0 1 1 1 0 Ring finger domain Jnk-SapK_ap_N PF09744.9 ELR16512.1 - 1.1 9.4 17.9 2 8.7 17.9 1.4 1 1 0 1 1 1 0 JNK_SAPK-associated protein-1 UPF0242 PF06785.11 ELR16512.1 - 3.7 7.6 9.2 5.2 7.1 9.2 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus V_ATPase_I PF01496.19 ELR16512.1 - 3.9 5.3 7.7 4.5 5.1 7.7 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family MORN PF02493.20 ELR16513.1 - 1.3e-36 122.3 48.0 5.2e-08 32.3 0.7 7.1 7 0 0 7 7 7 7 MORN repeat DUF89 PF01937.19 ELR16514.1 - 6.3e-38 130.6 0.0 8.4e-38 130.2 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function DUF89 DUF4397 PF14344.6 ELR16515.1 - 7.5e-23 81.6 9.4 1e-15 58.6 5.0 2.1 1 1 1 2 2 2 2 Domain of unknown function (DUF4397) RhoGEF PF00621.20 ELR16516.1 - 2.5e-49 168.0 1.9 4.6e-49 167.1 1.9 1.5 1 0 0 1 1 1 1 RhoGEF domain DUF3395 PF11875.8 ELR16516.1 - 1.5e-06 28.1 0.4 1.3e-05 25.1 0.0 2.7 2 1 0 2 2 2 1 Domain of unknown function (DUF3395) Glutaminase PF04960.15 ELR16516.1 - 0.002 17.3 1.4 0.0051 16.0 1.4 1.6 1 0 0 1 1 1 1 Glutaminase IQ_SEC7_PH PF16453.5 ELR16516.1 - 0.019 14.9 0.4 0.38 10.7 0.0 2.6 2 0 0 2 2 2 0 PH domain TFIIA PF03153.13 ELR16516.1 - 0.59 10.1 4.0 0.94 9.4 4.0 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Syntaxin-6_N PF09177.11 ELR16516.1 - 0.69 10.5 3.6 1.3 9.7 0.2 2.8 2 0 0 2 2 2 0 Syntaxin 6, N-terminal RBD PF02196.15 ELR16518.1 - 1e-08 35.1 0.0 2.2e-08 34.0 0.0 1.5 1 0 0 1 1 1 1 Raf-like Ras-binding domain SIN1_PH PF16979.5 ELR16518.1 - 1.7e-07 31.5 0.0 4.8e-07 30.0 0.0 1.8 1 0 0 1 1 1 1 SAPK-interacting protein 1 (Sin1), Pleckstrin-homology Sec3-PIP2_bind PF15277.6 ELR16518.1 - 0.0011 19.1 0.0 0.0021 18.2 0.0 1.5 1 0 0 1 1 1 1 Exocyst complex component SEC3 N-terminal PIP2 binding PH RA PF00788.23 ELR16518.1 - 0.0067 17.0 0.0 0.23 12.1 0.0 2.4 2 0 0 2 2 2 1 Ras association (RalGDS/AF-6) domain CRIM PF16978.5 ELR16518.1 - 0.027 14.6 0.0 0.065 13.4 0.0 1.6 1 0 0 1 1 1 0 SAPK-interacting protein 1 (Sin1), middle CRIM domain FERM_N PF09379.10 ELR16518.1 - 0.056 13.4 0.0 0.22 11.5 0.0 2.0 2 0 0 2 2 2 0 FERM N-terminal domain TUG-UBL1 PF11470.8 ELR16518.1 - 0.058 13.6 0.1 0.21 11.9 0.0 1.9 2 0 0 2 2 2 0 TUG ubiquitin-like domain Mak10 PF04112.13 ELR16519.1 - 8.8e-33 113.2 0.1 3.3e-26 91.8 0.0 2.3 1 1 1 2 2 2 2 Mak10 subunit, NatC N(alpha)-terminal acetyltransferase AMP-binding PF00501.28 ELR16520.1 - 1.9e-97 326.6 0.0 2.3e-97 326.3 0.0 1.0 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 ELR16520.1 - 2.5e-16 60.4 0.4 2.5e-16 60.4 0.4 3.0 3 1 0 3 3 3 1 AMP-binding enzyme C-terminal domain An_peroxidase PF03098.15 ELR16521.1 - 1e-98 331.2 0.0 6.8e-95 318.6 0.0 2.1 1 1 1 2 2 2 2 Animal haem peroxidase Pkinase_Tyr PF07714.17 ELR16521.1 - 2.8e-46 157.9 0.0 3.9e-46 157.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ELR16521.1 - 3e-41 141.5 0.0 4.8e-41 140.9 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain DOMON PF03351.17 ELR16521.1 - 6e-24 84.6 0.0 1e-23 83.9 0.0 1.4 1 0 0 1 1 1 1 DOMON domain DUF5326 PF17260.2 ELR16521.1 - 0.12 12.6 1.7 0.24 11.6 1.7 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5326) Pkinase_fungal PF17667.1 ELR16521.1 - 0.12 11.1 0.0 0.24 10.1 0.0 1.4 1 0 0 1 1 1 0 Fungal protein kinase APH_6_hur PF04655.14 ELR16521.1 - 0.14 11.6 0.1 0.26 10.6 0.1 1.4 1 0 0 1 1 1 0 Aminoglycoside/hydroxyurea antibiotic resistance kinase Pox_ser-thr_kin PF05445.11 ELR16521.1 - 0.29 10.1 0.0 0.43 9.5 0.0 1.1 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase CBAH PF02275.18 ELR16523.1 - 0.071 12.7 0.0 0.17 11.5 0.0 1.7 1 1 0 1 1 1 0 Linear amide C-N hydrolases, choloylglycine hydrolase family Thioredoxin_4 PF13462.6 ELR16524.1 - 2.2e-17 63.7 0.0 2.6e-17 63.5 0.0 1.0 1 0 0 1 1 1 1 Thioredoxin DSBA PF01323.20 ELR16524.1 - 6e-09 35.9 0.3 0.00032 20.5 0.0 2.3 2 1 0 2 2 2 2 DSBA-like thioredoxin domain Thioredoxin_5 PF13743.6 ELR16524.1 - 6.9e-05 22.6 0.0 9.8e-05 22.1 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_15 PF18403.1 ELR16524.1 - 0.091 12.7 0.0 0.12 12.3 0.0 1.1 1 0 0 1 1 1 0 Thioredoxin-like domain Tim17 PF02466.19 ELR16525.1 - 3.9e-08 33.6 0.1 3.9e-08 33.6 0.1 2.1 2 0 0 2 2 2 1 Tim17/Tim22/Tim23/Pmp24 family An_peroxidase PF03098.15 ELR16526.1 - 1.1e-104 351.0 0.0 1.7e-104 350.3 0.0 1.2 1 0 0 1 1 1 1 Animal haem peroxidase Pkinase_Tyr PF07714.17 ELR16526.1 - 5.7e-49 166.7 0.0 7.8e-49 166.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ELR16526.1 - 3e-43 148.1 0.0 4.9e-43 147.4 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain DOMON PF03351.17 ELR16526.1 - 3e-20 72.7 0.1 6.3e-20 71.6 0.1 1.6 1 0 0 1 1 1 1 DOMON domain Pkinase_fungal PF17667.1 ELR16526.1 - 0.013 14.4 0.0 0.021 13.6 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase Motile_Sperm PF00635.26 ELR16526.1 - 0.032 14.1 0.1 0.091 12.6 0.0 1.8 2 0 0 2 2 2 0 MSP (Major sperm protein) domain Pox_ser-thr_kin PF05445.11 ELR16526.1 - 0.059 12.3 0.0 0.093 11.7 0.0 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase ABC1 PF03109.16 ELR16526.1 - 0.065 13.4 0.0 0.17 12.0 0.0 1.6 1 0 0 1 1 1 0 ABC1 family An_peroxidase PF03098.15 ELR16527.1 - 7.9e-108 361.3 0.0 1.2e-107 360.8 0.0 1.1 1 0 0 1 1 1 1 Animal haem peroxidase Pkinase_Tyr PF07714.17 ELR16527.1 - 2.4e-48 164.7 0.0 3.3e-48 164.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ELR16527.1 - 1.2e-42 146.1 0.0 1.9e-42 145.4 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain DOMON PF03351.17 ELR16527.1 - 3.2e-20 72.6 0.1 6.4e-20 71.6 0.1 1.5 1 0 0 1 1 1 1 DOMON domain Pkinase_fungal PF17667.1 ELR16527.1 - 0.0058 15.5 0.0 0.011 14.5 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Motile_Sperm PF00635.26 ELR16527.1 - 0.028 14.2 0.0 0.081 12.8 0.0 1.7 1 0 0 1 1 1 0 MSP (Major sperm protein) domain Pox_ser-thr_kin PF05445.11 ELR16527.1 - 0.061 12.3 0.0 0.095 11.7 0.0 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase ABC1 PF03109.16 ELR16527.1 - 0.066 13.4 0.0 0.17 12.0 0.0 1.6 1 0 0 1 1 1 0 ABC1 family DUF423 PF04241.15 ELR16528.1 - 6e-21 74.5 2.6 7.9e-21 74.1 2.6 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF423) PsiA PF06952.11 ELR16529.1 - 0.075 12.3 9.1 0.17 11.1 8.8 1.6 1 1 0 1 1 1 0 PsiA protein AAA_11 PF13086.6 ELR16529.1 - 2.6 7.7 10.2 4.8 6.9 10.2 1.4 1 0 0 1 1 1 0 AAA domain Med19 PF10278.9 ELR16529.1 - 5.5 6.9 25.0 0.25 11.3 3.2 2.5 2 0 0 2 2 2 0 Mediator of RNA pol II transcription subunit 19 Beta_helix PF13229.6 ELR16530.1 - 2.2e-05 24.4 14.5 0.00013 21.9 14.4 2.4 1 1 0 1 1 1 1 Right handed beta helix region NosD PF05048.13 ELR16530.1 - 0.00074 18.9 8.7 0.0013 18.1 8.7 1.3 1 0 0 1 1 1 1 Periplasmic copper-binding protein (NosD) Pentapeptide_3 PF13576.6 ELR16530.1 - 2.3 8.4 5.5 1 9.6 0.4 3.2 3 0 0 3 3 3 0 Pentapeptide repeats (9 copies) DUF1681 PF07933.14 ELR16531.1 - 6.1e-05 22.8 0.0 0.00011 21.9 0.0 1.6 1 1 0 1 1 1 1 Protein of unknown function (DUF1681) WH1 PF00568.23 ELR16531.1 - 0.074 13.0 0.0 0.14 12.2 0.0 1.4 1 0 0 1 1 1 0 WH1 domain VPS9 PF02204.18 ELR16532.1 - 4.1e-07 30.2 0.0 8.9e-07 29.1 0.0 1.5 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain Tmpp129 PF10272.9 ELR16533.1 - 0.00067 19.1 16.1 0.0008 18.8 16.1 1.1 1 0 0 1 1 1 1 Putative transmembrane protein precursor Mito_carr PF00153.27 ELR16534.1 - 1.8e-49 165.6 4.3 1.1e-19 70.1 0.1 3.8 4 0 0 4 4 4 3 Mitochondrial carrier protein OAD_beta PF03977.13 ELR16535.1 - 0.091 11.7 0.0 0.097 11.6 0.0 1.1 1 0 0 1 1 1 0 Na+-transporting oxaloacetate decarboxylase beta subunit DUF3486 PF11985.8 ELR16536.1 - 0.061 13.7 0.0 0.067 13.6 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3486) Ank_3 PF13606.6 ELR16538.1 - 2.4e-07 30.5 9.5 0.16 12.6 0.1 5.1 5 0 0 5 5 5 3 Ankyrin repeat Ank_2 PF12796.7 ELR16538.1 - 3.9e-06 27.4 3.1 0.29 11.7 0.3 4.0 3 2 0 3 3 3 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 ELR16538.1 - 3.7e-05 23.9 6.1 0.073 13.4 0.0 4.2 4 0 0 4 4 4 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 ELR16538.1 - 4.1e-05 24.1 3.5 0.23 12.1 0.3 4.0 3 1 0 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.30 ELR16538.1 - 0.00016 22.0 20.1 0.022 15.2 0.5 5.3 5 1 0 5 5 5 2 Ankyrin repeat YEATS PF03366.16 ELR16538.1 - 0.0015 18.5 0.0 0.0028 17.6 0.0 1.4 1 0 0 1 1 1 1 YEATS family Ras PF00071.22 ELR16539.1 - 1.5e-08 34.4 0.0 2e-08 34.0 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR16539.1 - 0.00044 20.4 0.0 0.00061 20.0 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR16539.1 - 0.0032 17.0 0.0 0.0038 16.7 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 ELR16539.1 - 0.13 11.7 0.0 0.17 11.3 0.0 1.1 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit Methyltransf_11 PF08241.12 ELR16541.1 - 1.1e-11 45.3 0.4 3.3e-10 40.5 0.4 2.5 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 ELR16541.1 - 1.3e-10 41.0 0.1 3.6e-08 33.0 0.0 2.1 2 0 0 2 2 2 2 ubiE/COQ5 methyltransferase family Methyltransf_25 PF13649.6 ELR16541.1 - 1.8e-09 38.2 0.9 1.2e-06 29.1 0.3 3.0 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 ELR16541.1 - 2.1e-06 27.6 0.0 4.1e-06 26.7 0.0 1.4 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 ELR16541.1 - 6.9e-05 22.7 0.1 0.00049 19.9 0.1 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ELR16541.1 - 0.00055 20.6 0.0 0.0014 19.3 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain UPF0020 PF01170.18 ELR16541.1 - 0.00072 19.3 0.2 0.019 14.7 0.0 2.3 2 0 0 2 2 2 1 Putative RNA methylase family UPF0020 CbiJ PF02571.14 ELR16541.1 - 0.045 13.2 0.6 0.079 12.4 0.1 1.5 2 0 0 2 2 2 0 Precorrin-6x reductase CbiJ/CobK ParB_C PF18064.1 ELR16541.1 - 0.061 13.5 0.3 0.15 12.3 0.3 1.6 1 0 0 1 1 1 0 Centromere-binding protein ParB C-terminal PALP PF00291.25 ELR16542.1 - 6.3e-09 35.7 0.0 7.3e-09 35.5 0.0 1.0 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Chorismate_bind PF00425.18 ELR16543.1 - 3.5e-81 272.5 0.0 4.2e-81 272.3 0.0 1.0 1 0 0 1 1 1 1 chorismate binding enzyme SDH_C PF18317.1 ELR16544.1 - 2.4e-10 40.0 0.1 4.1e-10 39.2 0.1 1.4 1 0 0 1 1 1 1 Shikimate 5'-dehydrogenase C-terminal domain Chorismate_synt PF01264.21 ELR16545.1 - 2.9e-17 62.4 0.1 3.3e-17 62.2 0.1 1.0 1 0 0 1 1 1 1 Chorismate synthase Cellulase PF00150.18 ELR16548.1 - 4.7e-69 232.9 7.3 3.2e-33 115.4 5.4 3.0 2 1 0 2 2 2 2 Cellulase (glycosyl hydrolase family 5) Foamy_BEL PF03274.14 ELR16548.1 - 0.034 13.5 0.2 7 5.9 0.1 2.3 2 0 0 2 2 2 0 Foamy virus BEL 1/2 protein Ras PF00071.22 ELR16549.1 - 1.9e-25 89.3 0.0 2.3e-25 89.1 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR16549.1 - 2.1e-07 31.2 0.0 3.7e-07 30.4 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR16549.1 - 1.1e-05 25.0 0.0 1.3e-05 24.7 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 ELR16549.1 - 0.0076 15.8 0.0 0.012 15.2 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 ELR16549.1 - 0.012 15.5 0.0 0.016 15.1 0.0 1.2 1 0 0 1 1 1 0 RsgA GTPase Internalin_N PF12354.8 ELR16551.1 - 0.038 14.1 0.3 0.059 13.4 0.3 1.4 1 0 0 1 1 1 0 Bacterial adhesion/invasion protein N terminal YccF PF03733.13 ELR16552.1 - 1.6e-20 73.5 22.8 3.2e-10 40.5 6.9 2.2 2 0 0 2 2 2 2 Inner membrane component domain Promethin PF16015.5 ELR16552.1 - 3.3e-05 23.8 0.9 3.3e-05 23.8 0.9 2.2 2 0 0 2 2 2 2 Promethin DUF1286 PF06939.11 ELR16552.1 - 0.0062 16.8 0.2 0.72 10.1 0.0 2.2 2 0 0 2 2 2 2 Protein of unknown function (DUF1286) PPTA PF01239.22 ELR16553.1 - 5.2e-19 67.3 16.0 0.00024 20.7 0.1 5.4 5 0 0 5 5 5 5 Protein prenyltransferase alpha subunit repeat MIF4G PF02854.19 ELR16554.1 - 2.9e-24 85.9 0.1 1.1e-23 84.1 0.0 2.1 2 0 0 2 2 2 1 MIF4G domain MA3 PF02847.17 ELR16554.1 - 2.4e-16 59.7 0.5 2.4e-16 59.7 0.5 3.2 3 0 0 3 3 3 1 MA3 domain SnoaL_2 PF12680.7 ELR16555.1 - 0.032 14.9 0.1 0.049 14.3 0.1 1.3 1 0 0 1 1 1 0 SnoaL-like domain Ras PF00071.22 ELR16556.1 - 1.9e-29 102.4 0.0 3.1e-29 101.7 0.0 1.3 1 0 0 1 1 1 1 Ras family Ank_2 PF12796.7 ELR16556.1 - 3.2e-23 82.1 0.3 2.1e-08 34.6 0.0 3.9 1 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ELR16556.1 - 1.8e-22 79.4 3.1 2.6e-05 24.7 0.0 5.3 3 2 2 5 5 5 5 Ankyrin repeats (many copies) Roc PF08477.13 ELR16556.1 - 2.7e-18 66.3 0.0 4.6e-18 65.6 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ank_5 PF13857.6 ELR16556.1 - 1.1e-15 57.5 5.0 2.5e-07 30.8 0.2 4.5 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank PF00023.30 ELR16556.1 - 6.7e-14 51.6 1.8 0.00016 21.9 0.1 4.9 4 0 0 4 4 4 2 Ankyrin repeat Ank_3 PF13606.6 ELR16556.1 - 4.6e-13 48.1 7.8 0.0033 17.8 0.0 7.6 6 1 0 6 6 6 3 Ankyrin repeat F-box-like PF12937.7 ELR16556.1 - 5.3e-07 29.4 0.2 1.3e-06 28.2 0.2 1.6 1 0 0 1 1 1 1 F-box-like Arf PF00025.21 ELR16556.1 - 2.5e-06 27.1 0.0 4.3e-06 26.3 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family F-box PF00646.33 ELR16556.1 - 6.3e-05 22.7 0.4 0.00019 21.2 0.4 1.8 1 0 0 1 1 1 1 F-box domain F-box_4 PF15966.5 ELR16556.1 - 0.00052 19.9 0.0 0.001 18.9 0.0 1.4 1 0 0 1 1 1 1 F-box MMR_HSR1 PF01926.23 ELR16556.1 - 0.01 15.9 0.0 0.019 15.0 0.0 1.5 1 0 0 1 1 1 0 50S ribosome-binding GTPase Ank_2 PF12796.7 ELR16557.1 - 2.8e-32 111.1 2.7 9.7e-16 58.1 0.0 3.6 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ELR16557.1 - 7e-29 99.8 1.5 4.2e-08 33.6 0.0 4.9 2 2 3 5 5 5 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 ELR16557.1 - 2.8e-21 73.3 3.6 9.4e-06 25.6 0.0 6.3 6 1 0 6 6 6 4 Ankyrin repeat Ank_5 PF13857.6 ELR16557.1 - 9.3e-20 70.4 4.5 3.5e-09 36.7 0.2 4.7 2 2 3 5 5 5 3 Ankyrin repeats (many copies) Ank PF00023.30 ELR16557.1 - 7.9e-19 67.2 2.2 2.8e-07 30.7 0.1 4.9 5 0 0 5 5 5 4 Ankyrin repeat F-box-like PF12937.7 ELR16557.1 - 0.17 11.8 0.1 0.33 10.9 0.1 1.4 1 0 0 1 1 1 0 F-box-like Ras PF00071.22 ELR16558.1 - 6e-43 146.2 0.0 7.8e-43 145.9 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR16558.1 - 8.5e-24 84.1 0.0 1.2e-23 83.6 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR16558.1 - 2.8e-14 52.9 0.0 3.6e-14 52.6 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 ELR16558.1 - 0.00043 20.2 0.0 0.45 10.4 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 ELR16558.1 - 0.0012 18.9 0.0 0.0019 18.3 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_33 PF13671.6 ELR16558.1 - 0.0032 17.6 0.1 0.009 16.2 0.0 1.8 2 0 0 2 2 2 1 AAA domain GTP_EFTU PF00009.27 ELR16558.1 - 0.012 15.2 0.0 0.019 14.5 0.0 1.4 1 0 0 1 1 1 0 Elongation factor Tu GTP binding domain AAA_22 PF13401.6 ELR16558.1 - 0.07 13.4 0.0 0.17 12.1 0.0 2.0 1 1 0 1 1 1 0 AAA domain Sigma54_activat PF00158.26 ELR16558.1 - 0.1 12.3 0.0 0.32 10.7 0.0 1.8 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_16 PF13191.6 ELR16558.1 - 0.1 13.0 0.0 0.22 11.9 0.0 1.8 1 1 0 1 1 1 0 AAA ATPase domain PNKP_ligase PF16542.5 ELR16558.1 - 0.1 12.1 0.0 0.14 11.6 0.0 1.2 1 0 0 1 1 1 0 PNKP adenylyltransferase domain, ligase domain AAA_5 PF07728.14 ELR16558.1 - 0.11 12.5 0.0 0.24 11.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_7 PF12775.7 ELR16558.1 - 0.19 11.2 0.0 0.32 10.5 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region Ank_4 PF13637.6 ELR16559.1 - 4.6e-08 33.5 0.0 1.1e-05 25.9 0.0 2.2 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 ELR16559.1 - 5.4e-05 23.3 0.1 0.54 11.0 0.0 2.9 2 2 0 2 2 2 2 Ankyrin repeat Ank PF00023.30 ELR16559.1 - 7.6e-05 23.0 0.1 0.26 11.8 0.0 2.3 2 0 0 2 2 2 2 Ankyrin repeat Ank_2 PF12796.7 ELR16559.1 - 0.00049 20.6 0.0 0.0019 18.8 0.0 1.8 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 ELR16559.1 - 0.002 18.4 0.0 14 6.2 0.0 3.1 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ras PF00071.22 ELR16560.1 - 1.7e-43 148.1 0.0 2.4e-43 147.5 0.0 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR16560.1 - 1e-27 96.7 0.0 1.5e-27 96.2 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR16560.1 - 1.7e-15 56.9 0.0 2.4e-15 56.4 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Ank_4 PF13637.6 ELR16560.1 - 2.2e-11 44.0 0.2 8.8e-08 32.6 0.0 2.3 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 ELR16560.1 - 2.7e-10 40.7 0.0 5.3e-10 39.7 0.0 1.5 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) F-box-like PF12937.7 ELR16560.1 - 4.6e-08 32.8 0.3 1.2e-07 31.5 0.3 1.7 1 0 0 1 1 1 1 F-box-like Ank_5 PF13857.6 ELR16560.1 - 1.1e-07 32.0 0.3 6.6e-07 29.5 0.2 2.3 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 ELR16560.1 - 4.7e-06 26.8 1.1 6.7e-05 23.2 0.1 2.8 3 0 0 3 3 2 1 Ankyrin repeat F-box PF00646.33 ELR16560.1 - 9.8e-05 22.1 0.2 0.00019 21.2 0.2 1.4 1 0 0 1 1 1 1 F-box domain Ank_3 PF13606.6 ELR16560.1 - 0.00012 22.3 0.3 0.0012 19.1 0.0 2.7 3 0 0 3 3 2 1 Ankyrin repeat F-box_4 PF15966.5 ELR16560.1 - 0.0016 18.3 0.0 0.0028 17.5 0.0 1.3 1 0 0 1 1 1 1 F-box TsaE PF02367.17 ELR16560.1 - 0.0047 16.9 0.0 0.0089 16.0 0.0 1.4 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE Gtr1_RagA PF04670.12 ELR16560.1 - 0.0064 15.9 0.0 0.0088 15.4 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 ELR16560.1 - 0.0086 16.2 0.0 0.02 15.0 0.0 1.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 ELR16560.1 - 0.014 15.4 0.0 1.6 8.6 0.0 2.3 2 0 0 2 2 2 0 RsgA GTPase AAA_16 PF13191.6 ELR16560.1 - 0.068 13.6 0.1 0.19 12.1 0.0 1.7 2 0 0 2 2 2 0 AAA ATPase domain AAA_5 PF07728.14 ELR16560.1 - 0.13 12.3 0.0 0.62 10.1 0.0 2.0 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) Peptidase_C1 PF00112.23 ELR16562.1 - 2.4e-65 220.7 6.2 3.1e-65 220.3 6.2 1.1 1 0 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.12 ELR16562.1 - 3.7e-15 56.1 4.8 3.7e-15 56.1 4.8 1.7 2 0 0 2 2 2 1 Cathepsin propeptide inhibitor domain (I29) Peptidase_C1_2 PF03051.15 ELR16562.1 - 0.011 14.5 0.2 0.024 13.4 0.2 1.4 1 0 0 1 1 1 0 Peptidase C1-like family Ras PF00071.22 ELR16563.1 - 1.3e-46 158.1 0.0 1.9e-46 157.6 0.0 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR16563.1 - 1.1e-28 99.9 0.0 1.6e-28 99.3 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ank_4 PF13637.6 ELR16563.1 - 7.1e-24 83.9 1.7 3.8e-05 24.1 0.0 5.2 2 2 3 5 5 5 5 Ankyrin repeats (many copies) Ank_2 PF12796.7 ELR16563.1 - 1.8e-21 76.5 0.3 1.9e-06 28.4 0.0 3.5 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_5 PF13857.6 ELR16563.1 - 1.4e-16 60.4 4.4 5e-08 33.1 0.1 4.6 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Arf PF00025.21 ELR16563.1 - 1e-15 57.6 0.0 1.7e-15 57.0 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family Ank PF00023.30 ELR16563.1 - 1.7e-14 53.5 3.4 4.9e-05 23.6 0.1 4.9 4 1 0 4 4 4 3 Ankyrin repeat Ank_3 PF13606.6 ELR16563.1 - 4.9e-13 48.0 5.5 0.004 17.5 0.0 6.5 5 2 0 5 5 5 3 Ankyrin repeat F-box-like PF12937.7 ELR16563.1 - 3.1e-05 23.8 0.2 7e-05 22.6 0.2 1.6 1 0 0 1 1 1 1 F-box-like RsgA_GTPase PF03193.16 ELR16563.1 - 0.00094 19.1 0.0 0.57 10.1 0.0 2.4 2 0 0 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 ELR16563.1 - 0.0021 18.1 0.0 0.0038 17.3 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 ELR16563.1 - 0.005 16.4 0.0 0.0095 15.5 0.0 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 ELR16563.1 - 0.0092 15.3 0.0 0.013 14.8 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region AAA_16 PF13191.6 ELR16563.1 - 0.014 15.8 0.0 0.033 14.6 0.0 1.7 1 0 0 1 1 1 0 AAA ATPase domain Peptidase_S8 PF00082.22 ELR16564.1 - 5.9e-41 140.7 3.0 1.9e-40 139.0 3.0 1.7 1 1 0 1 1 1 1 Subtilase family Peripla_BP_4 PF13407.6 ELR16564.1 - 0.036 13.6 0.3 0.2 11.2 0.2 2.2 2 0 0 2 2 2 0 Periplasmic binding protein domain SlyX PF04102.12 ELR16565.1 - 3.1 8.5 5.8 5.3 7.7 1.8 2.5 2 0 0 2 2 2 0 SlyX TFIIA PF03153.13 ELR16566.1 - 8.9e-48 164.3 16.8 1.5e-29 104.3 10.6 2.0 1 1 1 2 2 2 2 Transcription factor IIA, alpha/beta subunit Cwf_Cwc_15 PF04889.12 ELR16566.1 - 0.068 12.9 1.0 0.13 12.0 1.0 1.5 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein DNA_pol_phi PF04931.13 ELR16566.1 - 5.9 4.9 7.6 8 4.4 7.6 1.1 1 0 0 1 1 1 0 DNA polymerase phi DUF4088 PF13317.6 ELR16567.1 - 0.14 11.7 5.6 0.23 11.0 5.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4088) ERM PF00769.19 ELR16567.1 - 0.47 10.2 52.8 0.68 9.7 22.8 2.1 1 1 1 2 2 2 0 Ezrin/radixin/moesin family Exonuc_VII_L PF02601.15 ELR16567.1 - 0.92 9.0 14.4 1.3 8.5 14.4 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit Peptidase_S49_N PF08496.10 ELR16567.1 - 1.7 8.7 8.4 12 5.9 0.2 2.5 1 1 1 2 2 2 0 Peptidase family S49 N-terminal An_peroxidase PF03098.15 ELR16568.1 - 1.7e-108 363.5 0.0 2.1e-108 363.2 0.0 1.0 1 0 0 1 1 1 1 Animal haem peroxidase Pkinase_Tyr PF07714.17 ELR16569.1 - 2.8e-49 167.7 0.0 4e-49 167.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ELR16569.1 - 3.3e-44 151.2 0.0 5.5e-44 150.5 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain DOMON PF03351.17 ELR16569.1 - 1.1e-11 45.1 0.1 7.4e-11 42.3 0.0 2.2 2 0 0 2 2 2 1 DOMON domain Pkinase_fungal PF17667.1 ELR16569.1 - 2e-05 23.5 0.0 4.2e-05 22.5 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase Kinocilin PF15033.6 ELR16569.1 - 0.063 12.9 0.0 0.16 11.6 0.0 1.7 1 0 0 1 1 1 0 Kinocilin protein Motile_Sperm PF00635.26 ELR16569.1 - 0.15 11.9 0.1 0.32 10.8 0.1 1.5 1 0 0 1 1 1 0 MSP (Major sperm protein) domain Syndecan PF01034.20 ELR16569.1 - 0.17 11.8 0.0 0.47 10.4 0.0 1.7 1 0 0 1 1 1 0 Syndecan domain Gram_pos_anchor PF00746.21 ELR16569.1 - 7.2 6.7 7.1 13 5.9 6.5 1.8 1 1 0 1 1 1 0 LPXTG cell wall anchor motif DAGK_acc PF00609.19 ELR16570.1 - 1.9e-38 132.3 0.0 3.9e-38 131.3 0.0 1.5 2 0 0 2 2 2 1 Diacylglycerol kinase accessory domain DAGK_cat PF00781.24 ELR16570.1 - 2e-23 82.4 0.0 3.3e-23 81.7 0.0 1.3 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain PH PF00169.29 ELR16570.1 - 2.6e-18 66.4 0.1 5.2e-18 65.5 0.1 1.5 1 0 0 1 1 1 1 PH domain PH_8 PF15409.6 ELR16570.1 - 9.2e-12 45.1 0.2 1.7e-11 44.3 0.2 1.4 1 0 0 1 1 1 1 Pleckstrin homology domain PH_11 PF15413.6 ELR16570.1 - 2.5e-08 34.3 2.0 1.6e-06 28.5 2.0 2.3 1 1 0 1 1 1 1 Pleckstrin homology domain PH_3 PF14593.6 ELR16570.1 - 2.1e-07 31.0 0.0 3.9e-07 30.1 0.0 1.3 1 0 0 1 1 1 1 PH domain WD40 PF00400.32 ELR16571.1 - 3.7e-17 62.4 10.5 1.1e-05 26.1 0.0 5.9 6 1 0 6 6 6 5 WD domain, G-beta repeat Nup88 PF10168.9 ELR16571.1 - 0.00054 17.9 0.1 0.00074 17.5 0.1 1.2 1 0 0 1 1 1 1 Nuclear pore component ANAPC4_WD40 PF12894.7 ELR16571.1 - 0.0016 18.7 0.3 0.56 10.5 0.1 3.6 2 1 0 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain DNA_pol_A_exoN PF18305.1 ELR16571.1 - 0.096 13.0 0.2 0.24 11.7 0.1 1.7 2 0 0 2 2 2 0 3' to 5' exonuclease C-terminal domain Bax1-I PF01027.20 ELR16572.1 - 5.5e-43 147.2 19.7 6.9e-43 146.9 19.7 1.1 1 0 0 1 1 1 1 Inhibitor of apoptosis-promoting Bax1 DUF2809 PF10990.8 ELR16572.1 - 0.059 14.0 0.8 0.059 14.0 0.8 2.9 3 1 0 3 3 3 0 Protein of unknown function (DUF2809) Keratin_assoc PF09775.9 ELR16572.1 - 0.43 10.2 11.4 0.65 9.7 6.6 2.7 2 1 1 3 3 3 0 Keratinocyte-associated protein 2 DUF2070 PF09843.9 ELR16572.1 - 1.9 6.7 14.3 2.2 6.4 14.3 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) DUF692 PF05114.13 ELR16573.1 - 2.7e-12 46.5 0.0 5.8e-12 45.4 0.0 1.5 1 1 0 1 1 1 1 Protein of unknown function (DUF692) TRAP_beta PF05753.14 ELR16574.1 - 4.5e-28 97.8 0.0 5.8e-28 97.5 0.0 1.1 1 0 0 1 1 1 1 Translocon-associated protein beta (TRAPB) DUF11 PF01345.18 ELR16574.1 - 0.18 12.1 0.4 0.33 11.3 0.4 1.6 1 1 0 1 1 1 0 Domain of unknown function DUF11 Spc7 PF08317.11 ELR16575.1 - 0.00085 18.3 18.0 0.00085 18.3 18.0 11.7 2 2 12 14 14 14 8 Spc7 kinetochore protein zf-met2 PF12907.7 ELR16576.1 - 4.9e-17 61.8 8.4 9.2e-17 60.9 8.4 1.5 1 0 0 1 1 1 1 Zinc-binding 4F5 PF04419.14 ELR16576.1 - 5.1e-08 33.6 9.5 5.1e-08 33.6 9.5 1.8 2 0 0 2 2 2 1 4F5 protein family zf-C2H2_12 PF18658.1 ELR16576.1 - 0.0022 17.5 0.1 0.0032 17.0 0.1 1.3 1 0 0 1 1 1 1 Zinc-finger C2H2-type zf-BED PF02892.15 ELR16576.1 - 0.023 14.7 1.2 0.042 13.9 1.2 1.5 1 0 0 1 1 1 0 BED zinc finger DAHP_synth_1 PF00793.20 ELR16577.1 - 4.5e-99 330.8 0.0 5.6e-99 330.5 0.0 1.0 1 0 0 1 1 1 1 DAHP synthetase I family PLDc_2 PF13091.6 ELR16578.1 - 1.1e-14 54.4 0.8 3.5e-11 43.1 0.0 3.1 3 0 0 3 3 3 2 PLD-like domain Pkinase PF00069.25 ELR16578.1 - 3.2e-12 46.4 2.8 5.3e-12 45.7 0.0 2.6 2 1 0 2 2 2 1 Protein kinase domain PLDc PF00614.22 ELR16578.1 - 1.6e-10 40.7 8.4 2.7e-07 30.5 0.2 3.3 4 0 0 4 4 4 2 Phospholipase D Active site motif Pkinase_Tyr PF07714.17 ELR16578.1 - 7.8e-09 35.2 0.3 5.1e-05 22.7 0.1 3.4 2 1 0 2 2 2 2 Protein tyrosine kinase SH2 PF00017.24 ELR16578.1 - 3.9e-06 26.9 0.1 1.9e-05 24.7 0.0 2.3 2 0 0 2 2 2 1 SH2 domain PH PF00169.29 ELR16578.1 - 0.00012 22.6 0.1 0.00044 20.7 0.1 2.1 1 0 0 1 1 1 1 PH domain Serglycin PF04360.12 ELR16578.1 - 1 9.3 10.8 3.6 7.5 0.1 4.2 4 0 0 4 4 4 0 Serglycin bZIP_1 PF00170.21 ELR16579.1 - 9e-10 38.5 17.2 4.4e-09 36.3 13.5 2.5 1 1 1 2 2 2 2 bZIP transcription factor bZIP_Maf PF03131.17 ELR16579.1 - 3.2e-06 27.6 13.7 3.2e-06 27.6 13.7 2.9 2 1 1 3 3 3 1 bZIP Maf transcription factor bZIP_2 PF07716.15 ELR16579.1 - 6.7e-06 26.1 11.2 6.7e-06 26.1 11.2 2.8 2 0 0 2 2 2 1 Basic region leucine zipper V_ATPase_I PF01496.19 ELR16579.1 - 0.0011 17.1 1.0 0.0012 16.8 1.0 1.2 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family DivIC PF04977.15 ELR16579.1 - 0.023 14.5 0.8 0.023 14.5 0.8 3.2 2 1 1 4 4 4 0 Septum formation initiator HALZ PF02183.18 ELR16579.1 - 0.029 14.6 1.7 0.029 14.6 1.7 2.7 3 0 0 3 3 3 0 Homeobox associated leucine zipper FapA PF03961.13 ELR16579.1 - 0.11 11.0 7.9 0.17 10.5 7.9 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A DUF417 PF04224.12 ELR16579.1 - 0.25 10.9 0.1 0.53 9.8 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function, DUF417 NEMP PF10225.9 ELR16579.1 - 1.4 8.5 5.2 0.86 9.2 2.7 2.0 2 0 0 2 2 2 0 NEMP family DUF724 PF05266.14 ELR16579.1 - 4.2 7.2 11.9 4.8 7.0 10.9 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF724) FlaC_arch PF05377.11 ELR16579.1 - 6.6 7.2 7.2 1.9 9.0 0.4 3.0 2 1 1 3 3 3 0 Flagella accessory protein C (FlaC) Spc7 PF08317.11 ELR16579.1 - 7.5 5.3 19.6 13 4.6 19.6 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF1084 PF06454.11 ELR16580.1 - 1.5e-09 37.7 23.1 5.5e-06 26.0 8.0 2.4 2 0 0 2 2 2 2 Protein of unknown function (DUF1084) ETRAMP PF09716.10 ELR16580.1 - 0.074 13.1 0.9 21 5.2 0.1 3.0 2 0 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) DUF4006 PF13179.6 ELR16580.1 - 0.086 12.8 0.5 5.5 7.0 0.0 3.0 2 0 0 2 2 2 0 Family of unknown function (DUF4006) DUF5134 PF17197.4 ELR16580.1 - 1.4 8.8 5.5 0.43 10.5 1.2 2.3 2 1 0 2 2 2 0 Domain of unknown function (DUF5134) Squash PF00299.18 ELR16581.1 - 0.28 11.2 4.5 1.8 8.6 3.0 3.3 2 0 0 2 2 2 0 Squash family serine protease inhibitor Cullin PF00888.22 ELR16582.1 - 3.2e-105 353.1 17.7 4.1e-105 352.7 17.7 1.1 1 0 0 1 1 1 1 Cullin family Cullin_Nedd8 PF10557.9 ELR16582.1 - 1.3e-15 57.2 0.2 5e-15 55.3 0.0 2.2 2 0 0 2 2 2 1 Cullin protein neddylation domain TetR_C_35 PF18556.1 ELR16582.1 - 0.0029 17.7 1.2 0.0077 16.4 1.2 1.8 1 0 0 1 1 1 1 Bacterial Tetracyclin repressor, C-terminal domain KdpA PF03814.15 ELR16582.1 - 0.13 10.4 4.5 0.2 9.8 4.5 1.1 1 0 0 1 1 1 0 Potassium-transporting ATPase A subunit zf-ANAPC11 PF12861.7 ELR16583.1 - 1.4e-35 121.3 14.9 1.7e-35 120.9 14.9 1.1 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-rbx1 PF12678.7 ELR16583.1 - 7e-22 77.5 15.0 1.2e-21 76.7 15.0 1.4 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_2 PF13639.6 ELR16583.1 - 1.6e-07 31.5 16.4 1.6e-06 28.3 16.4 2.2 1 1 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.6 ELR16583.1 - 0.001 19.0 13.2 0.0068 16.3 13.4 2.1 1 1 1 2 2 2 1 zinc-RING finger domain zf-C3HC4 PF00097.25 ELR16583.1 - 0.0015 18.3 11.6 0.0039 17.0 11.6 1.8 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 ELR16583.1 - 0.002 18.1 9.8 0.025 14.6 10.5 2.1 1 1 1 2 2 2 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 ELR16583.1 - 0.0043 16.9 11.9 0.0048 16.7 7.1 2.2 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 ELR16583.1 - 0.0095 16.1 4.4 0.0095 16.1 4.4 2.2 2 1 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-C3HC4_2 PF13923.6 ELR16583.1 - 0.011 15.6 9.9 0.011 15.6 9.9 2.7 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-Nse PF11789.8 ELR16583.1 - 0.028 14.2 6.5 0.05 13.4 6.5 1.5 1 1 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit FANCL_C PF11793.8 ELR16583.1 - 0.21 11.8 13.9 2 8.7 13.9 2.3 1 1 0 1 1 1 0 FANCL C-terminal domain zf-RING_11 PF17123.5 ELR16583.1 - 0.32 10.8 13.2 3.9 7.3 13.2 2.4 1 1 0 1 1 1 0 RING-like zinc finger DUF2321 PF10083.9 ELR16583.1 - 0.78 9.4 0.0 0.78 9.4 0.0 2.3 1 1 1 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2321) Zn_ribbon_17 PF17120.5 ELR16583.1 - 1.8 8.2 17.8 4.5 7.0 15.1 2.3 1 1 0 1 1 1 0 Zinc-ribbon, C4HC2 type Peptidase_M16_C PF05193.21 ELR16584.1 - 6.1e-24 85.0 0.0 9.1e-24 84.5 0.0 1.3 1 0 0 1 1 1 1 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 ELR16584.1 - 9.3e-22 77.6 0.0 1.5e-21 77.0 0.0 1.3 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) AKNA PF12443.8 ELR16586.1 - 0.0084 16.7 1.7 0.018 15.7 1.6 1.7 1 1 0 1 1 1 1 AT-hook-containing transcription factor SlyX PF04102.12 ELR16586.1 - 2.5 8.8 6.6 44 4.8 6.6 2.2 1 1 0 1 1 1 0 SlyX Peptidase_C14 PF00656.22 ELR16587.1 - 7.4e-51 173.5 0.0 1.5e-49 169.2 0.0 2.0 1 1 0 1 1 1 1 Caspase domain DHDPS PF00701.22 ELR16588.1 - 5.9e-40 136.8 0.0 7.3e-40 136.5 0.0 1.0 1 0 0 1 1 1 1 Dihydrodipicolinate synthetase family Arm PF00514.23 ELR16589.1 - 8e-23 79.7 20.4 5.8e-06 26.2 0.0 10.2 11 0 0 11 11 11 6 Armadillo/beta-catenin-like repeat V-ATPase_H_N PF03224.14 ELR16589.1 - 3e-10 39.9 18.6 0.017 14.5 3.3 4.8 2 1 2 4 4 4 4 V-ATPase subunit H HEAT_2 PF13646.6 ELR16589.1 - 2.2e-07 31.2 12.3 0.00045 20.6 0.4 5.3 4 2 0 4 4 4 2 HEAT repeats HEAT PF02985.22 ELR16589.1 - 5.6e-07 29.3 5.9 0.012 15.8 0.1 5.8 5 0 0 5 5 5 2 HEAT repeat HEAT_EZ PF13513.6 ELR16589.1 - 5.6e-06 26.7 7.0 1.7 9.3 0.1 5.4 4 1 1 5 5 5 3 HEAT-like repeat Arm_2 PF04826.13 ELR16589.1 - 3.4e-05 23.4 9.3 0.0031 17.0 0.6 4.0 3 1 1 4 4 4 2 Armadillo-like V-ATPase_H_C PF11698.8 ELR16589.1 - 0.00016 21.8 1.1 0.068 13.3 0.0 4.1 4 1 1 5 5 5 1 V-ATPase subunit H DUF3361 PF11841.8 ELR16589.1 - 0.078 12.9 16.4 0.56 10.1 0.1 5.2 2 2 2 5 5 5 0 Domain of unknown function (DUF3361) DUF2019 PF09450.10 ELR16589.1 - 0.078 12.9 1.8 0.18 11.7 0.1 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF2019) ORC6 PF05460.13 ELR16589.1 - 0.34 10.1 2.0 0.57 9.4 0.1 2.0 2 0 0 2 2 2 0 Origin recognition complex subunit 6 (ORC6) RTP1_C1 PF10363.9 ELR16589.1 - 0.98 9.6 6.9 3.3 7.9 0.3 3.9 3 1 0 3 3 3 0 Required for nuclear transport of RNA pol II C-terminus 1 SARAF PF06682.12 ELR16590.1 - 8.8e-19 68.3 0.1 1e-18 68.1 0.1 1.1 1 0 0 1 1 1 1 SOCE-associated regulatory factor of calcium homoeostasis TPR_12 PF13424.6 ELR16591.1 - 3.4e-14 52.9 41.2 3e-07 30.6 2.7 8.8 9 1 0 9 9 9 4 Tetratricopeptide repeat TPR_8 PF13181.6 ELR16591.1 - 1.1e-07 31.5 5.5 0.077 13.2 0.0 6.1 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_10 PF13374.6 ELR16591.1 - 1.2e-07 31.4 25.3 0.12 12.3 0.0 9.2 9 0 0 9 9 9 3 Tetratricopeptide repeat TPR_1 PF00515.28 ELR16591.1 - 3.1e-07 29.9 11.0 0.0046 16.7 0.0 6.4 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_2 PF07719.17 ELR16591.1 - 3.8e-07 29.7 17.2 0.0079 16.2 0.0 7.9 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_7 PF13176.6 ELR16591.1 - 7.2e-06 25.7 14.3 0.012 15.6 0.2 6.5 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_11 PF13414.6 ELR16591.1 - 0.037 13.7 1.0 0.53 10.0 0.0 3.3 3 0 0 3 3 3 0 TPR repeat SHNi-TPR PF10516.9 ELR16591.1 - 0.23 10.9 3.5 25 4.4 0.2 3.7 3 0 0 3 3 3 0 SHNi-TPR TPR_14 PF13428.6 ELR16591.1 - 1.3 10.0 41.1 2.1 9.4 0.5 10.1 10 1 0 10 10 10 0 Tetratricopeptide repeat Pro-kuma_activ PF09286.11 ELR16592.1 - 3.8e-33 114.8 0.0 1.1e-31 110.0 0.0 2.7 3 0 0 3 3 3 1 Pro-kumamolisin, activation domain Peptidase_S8 PF00082.22 ELR16592.1 - 0.011 15.1 0.1 0.016 14.5 0.1 1.2 1 0 0 1 1 1 0 Subtilase family DUF4570 PF15134.6 ELR16592.1 - 0.084 12.9 0.0 3.2 7.8 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4570) Glyco_hydro_14 PF01373.17 ELR16593.1 - 6.6e-116 387.6 3.2 7.7e-116 387.3 3.2 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 14 Peptidase_M19 PF01244.21 ELR16593.1 - 0.11 11.7 0.0 0.17 11.0 0.0 1.2 1 0 0 1 1 1 0 Membrane dipeptidase (Peptidase family M19) DUF2828 PF11443.8 ELR16594.1 - 0.01 13.9 1.1 0.014 13.5 1.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) DUF913 PF06025.12 ELR16594.1 - 0.014 14.4 1.4 0.019 14.0 1.4 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) ECSIT PF06239.11 ELR16594.1 - 0.015 14.4 5.2 0.012 14.8 3.9 1.4 2 0 0 2 2 2 0 Evolutionarily conserved signalling intermediate in Toll pathway Roughex PF06020.11 ELR16594.1 - 0.062 12.4 5.7 0.085 11.9 5.7 1.3 1 0 0 1 1 1 0 Drosophila roughex protein Presenilin PF01080.17 ELR16594.1 - 0.16 10.7 2.7 0.22 10.2 2.7 1.1 1 0 0 1 1 1 0 Presenilin NOA36 PF06524.12 ELR16594.1 - 0.24 10.7 5.9 0.36 10.1 5.9 1.2 1 0 0 1 1 1 0 NOA36 protein Pox_Ag35 PF03286.14 ELR16594.1 - 0.27 11.0 5.1 0.44 10.3 5.1 1.3 1 0 0 1 1 1 0 Pox virus Ag35 surface protein Herpes_LMP2 PF07415.11 ELR16594.1 - 0.32 9.7 0.1 0.43 9.3 0.1 1.1 1 0 0 1 1 1 0 Gammaherpesvirus latent membrane protein (LMP2) protein POX PF07526.11 ELR16594.1 - 0.39 11.3 2.1 0.67 10.5 2.1 1.3 1 0 0 1 1 1 0 Associated with HOX FancD2 PF14631.6 ELR16594.1 - 1.1 6.6 3.3 1.4 6.2 3.3 1.0 1 0 0 1 1 1 0 Fanconi anaemia protein FancD2 nuclease NPR3 PF03666.13 ELR16594.1 - 1.7 7.4 5.9 2 7.1 5.9 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 DUF3408 PF11888.8 ELR16594.1 - 2 8.6 10.1 0.11 12.7 4.7 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3408) Nucleo_P87 PF07267.11 ELR16594.1 - 4.5 6.0 9.9 1.8 7.3 7.4 1.5 1 1 1 2 2 2 0 Nucleopolyhedrovirus capsid protein P87 Ribosomal_60s PF00428.19 ELR16594.1 - 9.8 6.8 12.2 22 5.7 11.3 2.1 2 0 0 2 2 2 0 60s Acidic ribosomal protein Polbeta PF18765.1 ELR16595.1 - 0.01 15.9 0.0 0.029 14.4 0.0 1.7 1 0 0 1 1 1 0 Polymerase beta, Nucleotidyltransferase RlaP PF10127.9 ELR16595.1 - 0.055 13.1 0.6 0.18 11.4 0.5 1.9 1 1 0 1 1 1 0 RNA repair pathway DNA polymerase beta family zf-met PF12874.7 ELR16595.1 - 0.084 13.3 0.5 0.18 12.2 0.5 1.6 1 0 0 1 1 1 0 Zinc-finger of C2H2 type GFA PF04828.14 ELR16596.1 - 0.11 12.8 0.0 0.18 12.2 0.0 1.3 1 0 0 1 1 1 0 Glutathione-dependent formaldehyde-activating enzyme ATG27 PF09451.10 ELR16597.1 - 4e-08 33.4 0.0 6.7e-08 32.7 0.0 1.3 1 0 0 1 1 1 1 Autophagy-related protein 27 Neurensin PF14927.6 ELR16597.1 - 0.082 12.6 0.1 0.082 12.6 0.1 2.3 2 0 0 2 2 2 0 Neurensin MHYT PF03707.16 ELR16597.1 - 4.1 7.6 7.2 1.7 8.9 0.9 2.4 2 0 0 2 2 2 0 Bacterial signalling protein N terminal repeat Tad PF13400.6 ELR16597.1 - 5.4 7.4 9.6 14 6.1 1.8 2.4 2 0 0 2 2 2 0 Putative Flp pilus-assembly TadE/G-like Ank_4 PF13637.6 ELR16598.1 - 9.5e-50 166.4 12.1 5.3e-10 39.6 0.1 8.6 3 3 6 9 9 9 9 Ankyrin repeats (many copies) Ank_2 PF12796.7 ELR16598.1 - 4.1e-46 155.5 11.7 1.7e-11 44.5 0.1 5.7 2 2 4 6 6 6 6 Ankyrin repeats (3 copies) RhoGEF PF00621.20 ELR16598.1 - 3.1e-42 144.9 0.6 5.1e-42 144.2 0.6 1.4 1 0 0 1 1 1 1 RhoGEF domain Ank_3 PF13606.6 ELR16598.1 - 2.4e-40 131.9 13.7 0.0021 18.4 0.0 10.0 9 0 0 9 9 9 8 Ankyrin repeat Ank PF00023.30 ELR16598.1 - 8e-34 114.6 20.6 2.4e-05 24.6 0.2 10.5 10 0 0 10 10 10 6 Ankyrin repeat Ank_5 PF13857.6 ELR16598.1 - 4.5e-33 112.9 19.7 7.7e-09 35.6 0.3 8.1 5 3 3 8 8 8 8 Ankyrin repeats (many copies) SH3_2 PF07653.17 ELR16598.1 - 2.7e-11 43.0 0.1 7.6e-11 41.5 0.1 1.8 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 ELR16598.1 - 2e-10 40.1 0.6 3.9e-10 39.2 0.6 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 ELR16598.1 - 1e-09 38.1 0.3 2.1e-09 37.1 0.3 1.6 1 0 0 1 1 1 1 Variant SH3 domain PH PF00169.29 ELR16598.1 - 4.3e-07 30.4 0.0 9.3e-07 29.3 0.0 1.6 1 0 0 1 1 1 1 PH domain PH_16 PF17838.1 ELR16598.1 - 0.029 14.2 0.7 0.13 12.1 0.1 2.3 2 0 0 2 2 2 0 PH domain IQ_SEC7_PH PF16453.5 ELR16598.1 - 0.041 13.9 0.0 0.088 12.8 0.0 1.5 1 0 0 1 1 1 0 PH domain PglD_N PF17836.1 ELR16598.1 - 0.072 13.7 0.3 1.4 9.6 0.1 2.7 2 0 0 2 2 2 0 PglD N-terminal domain DUF3447 PF11929.8 ELR16598.1 - 0.33 10.9 3.1 0.85 9.6 0.0 3.0 4 0 0 4 4 4 0 Domain of unknown function (DUF3447) Ank_4 PF13637.6 ELR16599.1 - 3.7e-15 56.1 1.3 1.1e-07 32.2 0.1 2.9 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 ELR16599.1 - 1.7e-14 54.2 0.2 1.1e-06 29.1 0.0 2.5 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.30 ELR16599.1 - 3.3e-11 43.1 3.0 0.001 19.4 0.0 4.4 5 0 0 5 5 5 2 Ankyrin repeat Ank_5 PF13857.6 ELR16599.1 - 2.5e-10 40.4 2.4 0.00031 21.0 0.1 3.9 2 1 2 4 4 4 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 ELR16599.1 - 7e-09 35.2 0.4 0.02 15.4 0.0 3.9 3 0 0 3 3 3 2 Ankyrin repeat Metallophos PF00149.28 ELR16599.1 - 1.9e-08 35.0 0.0 4.3e-08 33.9 0.0 1.6 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 ELR16599.1 - 3.9e-08 33.7 0.0 2.1e-07 31.3 0.0 2.0 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Thg1 PF04446.12 ELR16600.1 - 1.2e-30 106.1 0.0 1.6e-30 105.7 0.0 1.2 1 0 0 1 1 1 1 tRNAHis guanylyltransferase RhoGAP PF00620.27 ELR16601.1 - 6e-33 113.8 0.0 1.6e-32 112.4 0.0 1.8 1 1 0 1 1 1 1 RhoGAP domain BAR_3 PF16746.5 ELR16601.1 - 5.3e-09 36.1 9.5 1.9e-07 31.0 9.5 2.1 1 1 0 1 1 1 1 BAR domain of APPL family SH3_9 PF14604.6 ELR16601.1 - 0.00013 21.7 0.0 0.00013 21.7 0.0 2.0 3 0 0 3 3 3 1 Variant SH3 domain Vps5 PF09325.10 ELR16601.1 - 0.0059 16.2 0.6 0.0059 16.2 0.6 2.2 1 1 1 2 2 2 1 Vps5 C terminal like SH3_1 PF00018.28 ELR16601.1 - 0.011 15.3 0.0 0.028 14.0 0.0 1.7 1 0 0 1 1 1 0 SH3 domain Cas_Csn2 PF09711.10 ELR16601.1 - 0.79 9.4 4.6 4.9 6.8 0.1 2.5 2 1 1 3 3 3 0 CRISPR-associated protein (Cas_Csn2) WD40 PF00400.32 ELR16602.1 - 1.5e-91 297.8 47.0 6.4e-09 36.3 0.9 14.4 14 0 0 14 14 14 12 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ELR16602.1 - 6.6e-17 61.6 12.0 0.00091 19.5 0.1 8.7 2 2 7 9 9 9 4 Anaphase-promoting complex subunit 4 WD40 domain DUF4062 PF13271.6 ELR16602.1 - 8.4e-12 45.3 0.0 2e-11 44.1 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4062) eIF2A PF08662.11 ELR16602.1 - 4.3e-11 43.1 4.0 0.0015 18.4 0.0 5.1 2 2 2 5 5 5 4 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 ELR16602.1 - 1.1e-10 41.1 10.5 2 7.3 0.0 9.2 4 2 4 9 9 9 3 WD40 region of Ge1, enhancer of mRNA-decapping protein AAA_16 PF13191.6 ELR16602.1 - 2.2e-10 41.2 0.1 6.4e-10 39.7 0.1 1.8 1 0 0 1 1 1 1 AAA ATPase domain BRCT_2 PF16589.5 ELR16602.1 - 1.3e-06 28.7 0.0 3.8e-06 27.2 0.0 1.8 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain NACHT PF05729.12 ELR16602.1 - 3.3e-06 27.1 0.1 1.1e-05 25.4 0.1 1.9 1 1 0 1 1 1 1 NACHT domain APAF1_C PF17908.1 ELR16602.1 - 8.4e-06 25.8 0.0 1.8e-05 24.7 0.0 1.5 1 0 0 1 1 1 1 APAF-1 helical domain BRCT PF00533.26 ELR16602.1 - 3.2e-05 24.2 0.0 0.00012 22.3 0.0 2.1 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain PD40 PF07676.12 ELR16602.1 - 5.8e-05 22.9 8.7 17 5.5 0.1 9.5 11 0 0 11 11 10 0 WD40-like Beta Propeller Repeat WD40_like PF17005.5 ELR16602.1 - 0.0029 17.0 0.0 6.5 6.0 0.0 3.8 2 2 0 3 3 3 1 WD40-like domain TniB PF05621.11 ELR16602.1 - 0.0044 16.4 0.0 0.01 15.3 0.0 1.5 1 0 0 1 1 1 1 Bacterial TniB protein Cytochrom_D1 PF02239.16 ELR16602.1 - 0.0059 15.2 2.9 2.2 6.7 0.0 4.4 4 2 2 6 6 6 1 Cytochrome D1 heme domain Nup160 PF11715.8 ELR16602.1 - 0.016 13.9 11.2 0.11 11.1 0.1 5.4 2 2 2 5 5 5 0 Nucleoporin Nup120/160 PTCB-BRCT PF12738.7 ELR16602.1 - 0.018 15.0 0.0 0.038 13.9 0.0 1.5 1 0 0 1 1 1 0 twin BRCT domain DUF87 PF01935.17 ELR16602.1 - 0.032 14.3 0.3 0.15 12.1 0.0 2.1 2 1 1 3 3 3 0 Helicase HerA, central domain AAA_22 PF13401.6 ELR16602.1 - 0.034 14.4 0.0 0.092 13.0 0.0 1.7 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 ELR16602.1 - 0.038 14.5 0.0 0.083 13.4 0.0 1.5 1 0 0 1 1 1 0 ABC transporter Ploopntkinase3 PF18751.1 ELR16602.1 - 0.079 12.9 0.0 0.16 11.8 0.0 1.4 1 0 0 1 1 1 0 P-loop Nucleotide Kinase3 Frtz PF11768.8 ELR16602.1 - 0.085 11.2 0.1 17 3.5 0.0 3.2 2 1 2 4 4 4 0 WD repeat-containing and planar cell polarity effector protein Fritz ATPase_2 PF01637.18 ELR16602.1 - 0.091 12.7 0.1 0.31 10.9 0.1 1.8 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea KAP_NTPase PF07693.14 ELR16602.1 - 0.14 11.4 0.0 3.6 6.7 0.0 2.3 1 1 0 1 1 1 0 KAP family P-loop domain Str_synth PF03088.16 ELR16602.1 - 0.15 12.2 0.1 2.5 8.3 0.0 3.1 3 1 1 4 4 3 0 Strictosidine synthase Zeta_toxin PF06414.12 ELR16602.1 - 0.15 11.3 0.0 0.3 10.3 0.0 1.5 1 0 0 1 1 1 0 Zeta toxin SRA PF18491.1 ELR16602.1 - 0.17 12.0 0.0 5.4 7.1 0.0 2.9 3 1 0 3 3 3 0 SET and RING associated domain Proteasome_A_N PF10584.9 ELR16602.1 - 2.6 7.8 6.4 29 4.5 0.1 4.7 4 0 0 4 4 4 0 Proteasome subunit A N-terminal signature adh_short PF00106.25 ELR16604.1 - 7.1e-05 22.3 0.0 0.00013 21.5 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ELR16604.1 - 0.037 13.6 0.0 0.045 13.3 0.0 1.1 1 0 0 1 1 1 0 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 ELR16606.1 - 4.2e-29 101.4 0.0 2.3e-27 95.7 0.0 2.8 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ELR16606.1 - 1.1e-19 70.9 0.0 2.9e-18 66.3 0.0 2.6 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ELR16606.1 - 0.00026 20.9 0.0 0.00066 19.6 0.0 1.7 1 1 0 1 1 1 1 KR domain NAD_binding_10 PF13460.6 ELR16606.1 - 0.032 14.1 0.2 0.25 11.2 0.1 2.1 2 0 0 2 2 2 0 NAD(P)H-binding STAS_2 PF13466.6 ELR16606.1 - 0.069 13.5 0.3 2.9 8.3 0.0 2.7 2 0 0 2 2 2 0 STAS domain Epimerase PF01370.21 ELR16606.1 - 0.12 11.8 0.1 0.44 10.0 0.1 1.8 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family PQQ_2 PF13360.6 ELR16607.1 - 2.5e-23 82.9 16.0 2.5e-14 53.4 2.9 3.5 1 1 0 2 2 2 2 PQQ-like domain PQQ PF01011.21 ELR16607.1 - 1.5e-18 65.7 15.1 0.0044 16.9 0.0 7.2 7 0 0 7 7 7 5 PQQ enzyme repeat PQQ_3 PF13570.6 ELR16607.1 - 7.3e-17 61.3 36.1 1.9e-05 25.0 2.1 9.3 8 2 0 8 8 8 6 PQQ-like domain DUF3389 PF11869.8 ELR16607.1 - 0.16 12.2 0.1 0.39 10.9 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3389) DUF179 PF02622.15 ELR16608.1 - 1.1e-10 41.7 0.1 1.7e-09 37.9 0.0 2.1 2 0 0 2 2 2 1 Uncharacterized ACR, COG1678 ANAPC15 PF15243.6 ELR16608.1 - 0.023 15.1 0.0 0.023 15.1 0.0 2.1 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 15 adh_short PF00106.25 ELR16609.1 - 5.7e-16 58.6 0.0 8.5e-15 54.7 0.0 2.0 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ELR16609.1 - 2.1e-12 47.1 0.0 1.6e-11 44.2 0.0 1.9 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ELR16609.1 - 7.7e-05 22.7 0.0 0.00014 21.9 0.0 1.4 1 1 0 1 1 1 1 KR domain NAD_binding_10 PF13460.6 ELR16609.1 - 0.052 13.4 0.1 0.074 12.9 0.1 1.2 1 0 0 1 1 1 0 NAD(P)H-binding DNA_pol_lambd_f PF10391.9 ELR16609.1 - 0.11 12.4 0.0 0.29 11.0 0.0 1.7 1 0 0 1 1 1 0 Fingers domain of DNA polymerase lambda NmrA PF05368.13 ELR16609.1 - 0.12 11.9 0.0 0.15 11.6 0.0 1.1 1 0 0 1 1 1 0 NmrA-like family PQQ PF01011.21 ELR16610.1 - 0.012 15.5 0.0 0.037 14.0 0.0 1.8 1 0 0 1 1 1 0 PQQ enzyme repeat PQQ_3 PF13570.6 ELR16610.1 - 2.3 8.8 14.2 2.5 8.7 1.6 3.7 2 1 0 2 2 2 0 PQQ-like domain ATG_C PF09333.11 ELR16611.1 - 0.025 14.9 0.1 0.031 14.6 0.1 1.3 1 1 0 1 1 1 0 Autophagy-related protein C terminal domain PLAC8 PF04749.17 ELR16612.1 - 1.9e-19 70.5 14.0 2.3e-19 70.2 14.0 1.1 1 0 0 1 1 1 1 PLAC8 family PBD PF00786.28 ELR16613.1 - 0.00012 22.4 0.0 0.00069 19.9 0.0 2.4 1 0 0 1 1 1 1 P21-Rho-binding domain DcpS_C PF11969.8 ELR16614.1 - 4.7e-29 101.2 10.6 1.5e-24 86.7 1.2 2.5 1 1 1 2 2 2 2 Scavenger mRNA decapping enzyme C-term binding HIT PF01230.23 ELR16614.1 - 0.00098 19.8 5.8 0.01 16.5 0.4 3.1 3 0 0 3 3 3 1 HIT domain NosL PF05573.12 ELR16614.1 - 0.001 19.4 0.1 2.3 8.6 0.0 2.6 1 1 1 2 2 2 2 NosL Radical_SAM PF04055.21 ELR16614.1 - 0.0083 16.5 0.0 8 6.8 0.0 3.3 2 1 1 3 3 3 1 Radical SAM superfamily Unstab_antitox PF09720.10 ELR16614.1 - 0.015 15.3 1.5 7.9 6.6 0.0 2.9 3 0 0 3 3 3 0 Putative addiction module component RhoGAP PF00620.27 ELR16616.1 - 5.7e-46 156.1 0.1 1.3e-45 154.9 0.1 1.6 1 0 0 1 1 1 1 RhoGAP domain SH3_1 PF00018.28 ELR16616.1 - 7.5e-17 60.7 0.2 1.8e-16 59.4 0.2 1.7 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 ELR16616.1 - 4.1e-14 52.2 0.3 1.3e-13 50.6 0.0 2.0 2 0 0 2 2 2 1 Variant SH3 domain PH PF00169.29 ELR16616.1 - 2.9e-13 50.2 0.2 7.3e-13 48.9 0.2 1.8 1 0 0 1 1 1 1 PH domain SH3_2 PF07653.17 ELR16616.1 - 1.6e-12 46.9 0.1 2.9e-12 46.0 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain PH_11 PF15413.6 ELR16616.1 - 0.0017 18.7 6.4 0.0021 18.5 3.0 2.8 2 1 0 2 2 2 1 Pleckstrin homology domain DUF3450 PF11932.8 ELR16616.1 - 0.0045 16.3 5.2 0.0045 16.3 5.2 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF3450) DUF3693 PF12472.8 ELR16616.1 - 0.0069 16.0 0.1 0.019 14.6 0.1 1.7 1 0 0 1 1 1 1 Phage related protein PH_8 PF15409.6 ELR16616.1 - 0.038 14.3 0.1 0.038 14.3 0.1 2.4 2 1 0 2 2 1 0 Pleckstrin homology domain YabA PF06156.13 ELR16616.1 - 0.23 12.1 6.0 0.14 12.8 0.2 2.8 1 1 1 2 2 2 0 Initiation control protein YabA MCU PF04678.13 ELR16616.1 - 0.83 9.7 2.9 0.92 9.6 0.8 2.1 2 0 0 2 2 2 0 Mitochondrial calcium uniporter Aldo_ket_red PF00248.21 ELR16617.1 - 7.6e-46 156.6 0.0 1.2e-43 149.4 0.0 2.0 1 1 0 1 1 1 1 Aldo/keto reductase family SURF6 PF04935.12 ELR16618.1 - 1.3e-19 70.8 95.2 1.3e-19 70.8 95.2 4.0 1 1 1 2 2 2 1 Surfeit locus protein 6 RRP14 PF15459.6 ELR16618.1 - 4.6e-06 27.1 0.0 4.6e-06 27.1 0.0 9.9 4 2 0 5 5 5 1 60S ribosome biogenesis protein Rrp14 ATP_bind_1 PF03029.17 ELR16619.1 - 1.8e-83 280.0 0.0 2.3e-83 279.7 0.0 1.1 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein AAA_31 PF13614.6 ELR16619.1 - 0.00017 21.6 0.0 0.0017 18.3 0.0 2.1 2 0 0 2 2 2 1 AAA domain MeaB PF03308.16 ELR16619.1 - 0.00066 18.7 0.0 0.0011 18.0 0.0 1.2 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB CbiA PF01656.23 ELR16619.1 - 0.0029 17.7 0.0 0.0042 17.1 0.0 1.4 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain SRP54 PF00448.22 ELR16619.1 - 0.0029 17.3 0.0 0.017 14.8 0.0 2.0 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain CLP1_P PF16575.5 ELR16619.1 - 0.0031 17.3 0.0 0.0094 15.8 0.0 1.9 1 1 0 1 1 1 1 mRNA cleavage and polyadenylation factor CLP1 P-loop AAA_30 PF13604.6 ELR16619.1 - 0.01 15.5 0.0 0.02 14.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 ELR16619.1 - 0.016 15.3 0.0 0.031 14.4 0.0 1.5 1 1 0 1 1 1 0 AAA domain BUD22 PF09073.10 ELR16619.1 - 0.024 14.0 4.9 0.029 13.7 4.9 1.1 1 0 0 1 1 1 0 BUD22 Fer4_NifH PF00142.18 ELR16619.1 - 0.025 14.0 0.0 0.07 12.6 0.0 1.6 2 0 0 2 2 2 0 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family RNA_helicase PF00910.22 ELR16619.1 - 0.026 14.9 0.0 0.085 13.3 0.0 1.9 2 0 0 2 2 1 0 RNA helicase AAA_24 PF13479.6 ELR16619.1 - 0.03 14.0 0.0 0.054 13.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain KTI12 PF08433.10 ELR16619.1 - 0.032 13.7 0.0 0.095 12.1 0.0 1.7 2 0 0 2 2 2 0 Chromatin associated protein KTI12 AAA_17 PF13207.6 ELR16619.1 - 0.068 13.6 0.2 0.16 12.4 0.2 1.6 1 0 0 1 1 1 0 AAA domain AAA PF00004.29 ELR16619.1 - 0.1 13.0 0.0 0.2 12.1 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) ArsA_ATPase PF02374.15 ELR16619.1 - 0.12 11.6 0.0 0.25 10.5 0.0 1.5 1 0 0 1 1 1 0 Anion-transporting ATPase AAA_22 PF13401.6 ELR16619.1 - 0.13 12.5 0.0 0.26 11.6 0.0 1.5 1 1 0 1 1 1 0 AAA domain AAA_5 PF07728.14 ELR16619.1 - 0.18 11.8 0.0 0.49 10.4 0.0 1.7 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) NTPase_1 PF03266.15 ELR16619.1 - 0.18 11.7 0.0 0.7 9.8 0.0 1.8 2 0 0 2 2 2 0 NTPase T2SSE PF00437.20 ELR16619.1 - 0.19 10.8 0.0 0.28 10.2 0.0 1.2 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_18 PF13238.6 ELR16619.1 - 0.21 12.1 2.5 0.25 11.9 0.3 2.3 2 1 0 2 2 2 0 AAA domain Myotub-related PF06602.14 ELR16620.1 - 4.7e-104 348.1 0.7 8e-103 344.0 0.7 2.2 1 1 0 1 1 1 1 Myotubularin-like phosphatase domain Fascin PF06268.13 ELR16620.1 - 0.00049 20.3 0.1 0.038 14.2 0.0 2.8 2 0 0 2 2 2 1 Fascin domain DUF1644 PF07800.12 ELR16620.1 - 0.015 15.4 0.1 0.015 15.4 0.1 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1644) Flagellin_N PF00669.20 ELR16620.1 - 0.62 10.2 0.0 0.62 10.2 0.0 2.4 2 0 0 2 2 2 0 Bacterial flagellin N-terminal helical region RhoGEF PF00621.20 ELR16621.1 - 1.6e-20 74.1 0.8 1.6e-20 74.1 0.8 2.2 2 0 0 2 2 2 1 RhoGEF domain IQ_SEC7_PH PF16453.5 ELR16621.1 - 2.4e-07 30.8 0.4 8.7e-07 29.0 0.1 2.1 2 0 0 2 2 2 1 PH domain PH PF00169.29 ELR16621.1 - 0.00098 19.6 0.0 0.0034 17.8 0.0 2.0 1 0 0 1 1 1 1 PH domain TEX12 PF15219.6 ELR16621.1 - 0.0046 17.3 0.4 0.016 15.5 0.4 1.9 1 0 0 1 1 1 1 Testis-expressed 12 IQ PF00612.27 ELR16621.1 - 0.038 13.8 1.0 0.12 12.2 1.0 2.0 1 0 0 1 1 1 0 IQ calmodulin-binding motif Ribosomal_L36e PF01158.18 ELR16622.1 - 4.8e-33 113.3 5.8 8.7e-33 112.4 5.8 1.3 1 0 0 1 1 1 1 Ribosomal protein L36e 4HB_MCP_1 PF12729.7 ELR16622.1 - 0.057 13.0 0.1 0.073 12.6 0.1 1.1 1 0 0 1 1 1 0 Four helix bundle sensory module for signal transduction 2OG-FeII_Oxy_2 PF13532.6 ELR16623.1 - 5.5e-32 111.5 0.0 7.2e-32 111.2 0.0 1.2 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily PhyH PF05721.13 ELR16623.1 - 0.12 12.6 0.0 13 5.9 0.0 2.2 1 1 1 2 2 2 0 Phytanoyl-CoA dioxygenase (PhyH) RhoGEF PF00621.20 ELR16624.1 - 6.1e-35 121.1 1.1 2.5e-22 80.0 0.2 2.6 2 0 0 2 2 2 2 RhoGEF domain Arm PF00514.23 ELR16624.1 - 3.4e-07 30.1 17.6 0.037 14.1 0.4 6.0 7 0 0 7 7 7 3 Armadillo/beta-catenin-like repeat Arm_2 PF04826.13 ELR16624.1 - 4.5e-05 23.0 8.1 0.00011 21.8 7.4 1.9 1 1 1 2 2 2 2 Armadillo-like PH PF00169.29 ELR16624.1 - 5.6e-05 23.6 0.0 0.00014 22.3 0.0 1.7 1 0 0 1 1 1 1 PH domain IQ_SEC7_PH PF16453.5 ELR16624.1 - 0.00033 20.7 0.0 0.0014 18.6 0.0 2.1 1 0 0 1 1 1 1 PH domain KAP PF05804.12 ELR16624.1 - 0.0027 15.9 3.5 0.007 14.6 3.2 1.7 2 0 0 2 2 2 1 Kinesin-associated protein (KAP) PUL PF08324.11 ELR16624.1 - 0.011 14.9 7.0 0.59 9.3 7.0 2.6 1 1 0 1 1 1 0 PUL domain Acatn PF13000.7 ELR16627.1 - 2.6e-129 432.2 16.2 2.9e-43 148.2 0.1 4.0 2 2 2 4 4 4 4 Acetyl-coenzyme A transporter 1 Cwf_Cwc_15 PF04889.12 ELR16627.1 - 0.19 11.5 11.2 0.27 10.9 11.2 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein SR-25 PF10500.9 ELR16627.1 - 0.32 10.6 16.0 0.19 11.3 14.1 1.4 1 1 0 1 1 1 0 Nuclear RNA-splicing-associated protein DNA_pol_phi PF04931.13 ELR16627.1 - 1.2 7.1 5.9 1.7 6.7 5.9 1.1 1 0 0 1 1 1 0 DNA polymerase phi IMUP PF15761.5 ELR16627.1 - 7.7 7.3 16.3 0.088 13.5 8.8 1.6 2 0 0 2 2 2 0 Immortalisation up-regulated protein DUF2062 PF09835.9 ELR16628.1 - 0.67 9.8 11.2 0.041 13.7 5.9 1.6 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2062) U-box PF04564.15 ELR16629.1 - 1.7e-13 50.5 0.0 3.9e-13 49.4 0.0 1.6 1 0 0 1 1 1 1 U-box domain zf-RING_UBOX PF13445.6 ELR16629.1 - 3.9e-06 26.8 0.5 7.4e-05 22.7 0.0 2.9 2 1 1 3 3 3 1 RING-type zinc-finger zf-RING_2 PF13639.6 ELR16629.1 - 9.6e-06 25.8 0.1 9.6e-06 25.8 0.1 3.1 2 1 1 3 3 2 1 Ring finger domain zf-C3HC4_2 PF13923.6 ELR16629.1 - 1.8e-05 24.5 0.1 1.8e-05 24.5 0.1 3.2 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 ELR16629.1 - 2.5e-05 24.4 0.1 2.5e-05 24.4 0.1 2.5 2 0 0 2 2 2 1 RING-H2 zinc finger domain zf-Nse PF11789.8 ELR16629.1 - 7.6e-05 22.5 0.0 0.00017 21.3 0.0 1.6 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-C3HC4_4 PF15227.6 ELR16629.1 - 0.00025 21.1 0.0 0.00025 21.1 0.0 2.7 2 1 0 2 2 1 1 zinc finger of C3HC4-type, RING SAM_1 PF00536.30 ELR16629.1 - 0.00048 20.5 1.2 0.0016 18.8 1.2 1.9 1 1 0 1 1 1 1 SAM domain (Sterile alpha motif) zf-ANAPC11 PF12861.7 ELR16629.1 - 0.00049 20.1 0.1 0.00049 20.1 0.1 2.2 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4 PF00097.25 ELR16629.1 - 0.00051 19.9 0.0 0.00051 19.9 0.0 2.7 2 1 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) SAM_PNT PF02198.16 ELR16629.1 - 0.0049 16.8 0.0 0.0089 16.0 0.0 1.3 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain SAM_2 PF07647.17 ELR16629.1 - 0.0068 16.5 1.0 0.024 14.7 1.0 1.9 1 1 0 1 1 1 1 SAM domain (Sterile alpha motif) Prok-RING_4 PF14447.6 ELR16629.1 - 0.016 15.1 0.1 0.016 15.1 0.1 2.3 3 0 0 3 3 2 0 Prokaryotic RING finger family 4 NOB1_Zn_bind PF08772.11 ELR16629.1 - 0.017 15.3 3.3 2.6 8.3 0.0 2.5 2 0 0 2 2 2 0 Nin one binding (NOB1) Zn-ribbon like U-box PF04564.15 ELR16630.1 - 5.7e-12 45.6 0.0 1.2e-11 44.6 0.0 1.5 1 0 0 1 1 1 1 U-box domain zf-rbx1 PF12678.7 ELR16630.1 - 3.3e-07 30.5 0.1 3.3e-07 30.5 0.1 3.0 2 1 0 2 2 2 1 RING-H2 zinc finger domain zf-Nse PF11789.8 ELR16630.1 - 7.8e-06 25.6 0.0 1.8e-05 24.4 0.0 1.6 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_2 PF13639.6 ELR16630.1 - 3.9e-05 23.9 0.1 3.9e-05 23.9 0.1 3.9 3 1 1 4 4 4 1 Ring finger domain zf-ANAPC11 PF12861.7 ELR16630.1 - 5.9e-05 23.0 0.2 5.9e-05 23.0 0.2 2.4 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_UBOX PF13445.6 ELR16630.1 - 7.3e-05 22.7 0.2 7.3e-05 22.7 0.2 2.9 3 1 0 3 3 3 1 RING-type zinc-finger zf-C3HC4 PF00097.25 ELR16630.1 - 0.0025 17.7 0.0 0.0025 17.7 0.0 3.8 3 1 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) DUF916 PF06030.12 ELR16630.1 - 0.23 11.5 0.0 0.37 10.9 0.0 1.3 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF916) DUF3099 PF11298.8 ELR16630.1 - 0.83 9.8 5.1 1.4 9.2 5.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3099) DUF2207 PF09972.9 ELR16630.1 - 4.3 6.0 6.5 6 5.5 6.5 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) zf-C2H2_jaz PF12171.8 ELR16632.1 - 0.051 13.9 0.1 0.09 13.1 0.1 1.4 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 ELR16632.1 - 0.054 13.9 0.0 0.16 12.4 0.0 1.9 1 0 0 1 1 1 0 Zinc-finger of C2H2 type zf-C2H2 PF00096.26 ELR16632.1 - 0.7 10.5 3.4 1.6 9.4 3.4 1.7 1 1 0 1 1 1 0 Zinc finger, C2H2 type ABC2_membrane PF01061.24 ELR16635.1 - 5e-30 104.5 22.1 8.5e-30 103.7 22.1 1.4 1 0 0 1 1 1 1 ABC-2 type transporter ABC_tran PF00005.27 ELR16635.1 - 3.8e-23 82.5 0.1 9.6e-23 81.2 0.0 1.8 2 0 0 2 2 1 1 ABC transporter AAA_21 PF13304.6 ELR16635.1 - 0.00014 21.8 0.2 0.4 10.4 0.0 2.2 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_30 PF13604.6 ELR16635.1 - 0.00023 20.9 0.6 0.00058 19.6 0.0 1.8 2 0 0 2 2 2 1 AAA domain AAA_25 PF13481.6 ELR16635.1 - 0.0007 19.2 1.5 0.0054 16.3 0.0 2.7 3 0 0 3 3 3 1 AAA domain RsgA_GTPase PF03193.16 ELR16635.1 - 0.0072 16.2 0.1 0.016 15.2 0.1 1.5 1 0 0 1 1 1 1 RsgA GTPase AAA_16 PF13191.6 ELR16635.1 - 0.011 16.1 1.5 0.017 15.5 0.2 2.0 2 1 0 2 2 2 0 AAA ATPase domain AAA_22 PF13401.6 ELR16635.1 - 0.016 15.4 0.4 0.11 12.7 0.0 2.4 3 0 0 3 3 3 0 AAA domain AAA_23 PF13476.6 ELR16635.1 - 0.018 15.6 0.1 0.13 12.8 0.1 1.9 2 0 0 2 2 2 0 AAA domain AAA_29 PF13555.6 ELR16635.1 - 0.021 14.6 0.1 0.045 13.5 0.1 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain SMC_N PF02463.19 ELR16635.1 - 0.037 13.5 0.0 6.4 6.1 0.0 2.3 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain Rad17 PF03215.15 ELR16635.1 - 0.057 13.3 0.0 0.11 12.4 0.0 1.4 1 0 0 1 1 1 0 Rad17 P-loop domain cobW PF02492.19 ELR16635.1 - 0.094 12.3 0.2 0.19 11.3 0.2 1.5 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain T2SSE PF00437.20 ELR16635.1 - 0.096 11.7 0.0 0.22 10.6 0.0 1.5 1 0 0 1 1 1 0 Type II/IV secretion system protein NACHT PF05729.12 ELR16635.1 - 0.097 12.6 0.9 0.14 12.1 0.1 1.7 2 0 0 2 2 2 0 NACHT domain ATPase_2 PF01637.18 ELR16635.1 - 0.12 12.3 0.0 0.24 11.3 0.0 1.5 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea MMR_HSR1 PF01926.23 ELR16635.1 - 0.14 12.2 0.3 0.35 11.0 0.0 1.8 2 0 0 2 2 2 0 50S ribosome-binding GTPase PNTB PF02233.16 ELR16636.1 - 2.4e-182 607.0 17.6 2.4e-182 607.0 17.6 2.2 2 0 0 2 2 2 1 NAD(P) transhydrogenase beta subunit AlaDh_PNT_C PF01262.21 ELR16636.1 - 2.1e-65 220.0 2.7 8.3e-63 211.5 2.7 2.6 1 1 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain AlaDh_PNT_N PF05222.15 ELR16636.1 - 4.8e-42 143.5 0.1 1.2e-41 142.2 0.1 1.7 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, N-terminal domain PNTB_4TM PF12769.7 ELR16636.1 - 4e-31 107.3 1.9 4e-31 107.3 1.9 4.1 4 1 0 4 4 4 1 4TM region of pyridine nucleotide transhydrogenase, mitoch 2-Hacid_dh_C PF02826.19 ELR16636.1 - 0.00047 19.6 0.7 0.41 10.0 0.1 3.0 3 0 0 3 3 3 2 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain TPP_enzyme_M PF00205.22 ELR16636.1 - 0.015 15.1 0.1 0.17 11.6 0.1 2.7 1 1 0 1 1 1 0 Thiamine pyrophosphate enzyme, central domain NAD_binding_8 PF13450.6 ELR16636.1 - 0.016 15.5 0.4 0.18 12.1 0.3 2.8 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 ELR16636.1 - 0.018 14.3 0.2 0.049 12.8 0.2 1.8 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase ADH_zinc_N PF00107.26 ELR16636.1 - 0.026 14.5 1.5 0.18 11.8 0.2 3.1 4 0 0 4 4 4 0 Zinc-binding dehydrogenase HI0933_like PF03486.14 ELR16636.1 - 0.097 11.4 0.5 0.44 9.2 0.6 2.0 2 0 0 2 2 2 0 HI0933-like protein GIDA PF01134.22 ELR16636.1 - 0.15 11.1 0.7 0.25 10.4 0.7 1.3 1 0 0 1 1 1 0 Glucose inhibited division protein A FAD_binding_2 PF00890.24 ELR16636.1 - 0.21 10.6 3.0 0.17 11.0 1.0 1.8 2 0 0 2 2 2 0 FAD binding domain 3HCDH_N PF02737.18 ELR16636.1 - 2.3 8.0 6.0 3.6 7.4 0.8 2.5 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Phage_holin_2_4 PF16082.5 ELR16636.1 - 8.2 6.2 11.9 3.1 7.6 1.0 3.8 2 1 1 3 3 3 0 Bacteriophage holin family, superfamily II-like Isochorismatase PF00857.20 ELR16637.1 - 5.2e-36 124.5 0.0 8.9e-36 123.7 0.0 1.4 1 1 0 1 1 1 1 Isochorismatase family Pyr_redox PF00070.27 ELR16637.1 - 0.14 12.7 0.0 0.3 11.7 0.0 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase zf-C3HC4_2 PF13923.6 ELR16638.1 - 4.6e-09 36.0 9.2 8.3e-09 35.2 9.2 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 ELR16638.1 - 1.1e-08 34.8 8.1 2e-08 34.0 8.1 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 ELR16638.1 - 1.6e-07 31.1 9.6 3.1e-07 30.2 9.6 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ELR16638.1 - 3.2e-05 23.8 8.6 6.7e-05 22.8 8.6 1.6 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 ELR16638.1 - 3.3e-05 23.8 7.6 6.3e-05 22.9 7.6 1.5 1 0 0 1 1 1 1 RING-type zinc-finger CENP-F_leu_zip PF10473.9 ELR16638.1 - 4.7e-05 23.4 1.5 4.7e-05 23.4 1.5 9.2 2 2 7 9 9 7 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 zf-RING_2 PF13639.6 ELR16638.1 - 0.0003 21.1 8.5 0.00051 20.3 8.5 1.4 1 0 0 1 1 1 1 Ring finger domain zf-RING_6 PF14835.6 ELR16638.1 - 0.00074 19.3 2.9 0.0014 18.4 2.9 1.4 1 0 0 1 1 1 1 zf-RING of BARD1-type protein Prok-RING_4 PF14447.6 ELR16638.1 - 0.0026 17.6 8.4 0.0049 16.7 8.4 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 Lebercilin PF15619.6 ELR16638.1 - 0.0027 17.4 3.0 0.0027 17.4 3.0 8.1 2 2 6 8 8 6 1 Ciliary protein causing Leber congenital amaurosis disease KxDL PF10241.9 ELR16638.1 - 0.0052 17.0 0.6 0.0052 17.0 0.6 8.9 5 2 5 11 11 11 2 Uncharacterized conserved protein Spc7 PF08317.11 ELR16638.1 - 0.0075 15.2 1.8 0.0075 15.2 1.8 8.1 2 1 6 9 9 8 3 Spc7 kinetochore protein zf-C3HC4_4 PF15227.6 ELR16638.1 - 0.0092 16.1 8.0 0.02 15.0 8.0 1.6 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING PRKG1_interact PF15898.5 ELR16638.1 - 0.019 15.8 4.2 0.019 15.8 4.2 8.6 3 3 4 7 7 5 0 cGMP-dependent protein kinase interacting domain zf-rbx1 PF12678.7 ELR16638.1 - 0.046 14.0 4.3 0.11 12.8 4.3 1.6 1 0 0 1 1 1 0 RING-H2 zinc finger domain HNOB PF07700.15 ELR16638.1 - 0.061 13.3 0.1 0.59 10.1 0.0 2.3 2 0 0 2 2 2 0 Haem-NO-binding DUF641 PF04859.12 ELR16638.1 - 0.31 11.4 0.0 0.31 11.4 0.0 9.2 4 2 4 9 9 9 0 Plant protein of unknown function (DUF641) zf-RING_10 PF16685.5 ELR16638.1 - 0.45 10.7 5.1 1 9.6 5.1 1.6 1 0 0 1 1 1 0 zinc RING finger of MSL2 zf-RING_4 PF14570.6 ELR16638.1 - 0.72 9.7 6.9 1.7 8.5 6.9 1.7 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain DUF3040 PF11239.8 ELR16639.1 - 0.071 13.4 0.3 0.18 12.1 0.3 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3040) PIRT PF15099.6 ELR16639.1 - 0.11 12.1 0.0 0.17 11.4 0.0 1.2 1 0 0 1 1 1 0 Phosphoinositide-interacting protein family LRR_6 PF13516.6 ELR16640.1 - 2.4e-35 117.5 21.8 7.8e-06 25.5 0.2 12.0 12 0 0 12 12 12 10 Leucine Rich repeat LRR_4 PF12799.7 ELR16640.1 - 0.00024 21.4 1.2 0.33 11.4 0.0 4.5 5 0 0 5 5 5 2 Leucine Rich repeats (2 copies) Hus1 PF04005.12 ELR16641.1 - 8.6e-80 268.0 3.0 1e-79 267.7 3.0 1.0 1 0 0 1 1 1 1 Hus1-like protein OGFr_N PF04664.13 ELR16642.1 - 3.8e-49 167.1 0.8 5.8e-49 166.5 0.8 1.2 1 0 0 1 1 1 1 Opioid growth factor receptor (OGFr) conserved region Hydrolase_4 PF12146.8 ELR16643.1 - 6.8e-09 35.3 0.1 0.00018 20.8 0.0 2.7 1 1 1 2 2 2 2 Serine aminopeptidase, S33 Peptidase_S9 PF00326.21 ELR16643.1 - 2.8e-06 26.9 0.1 0.0058 16.1 0.1 2.2 1 1 1 2 2 2 2 Prolyl oligopeptidase family Abhydrolase_6 PF12697.7 ELR16643.1 - 3.9e-06 27.6 0.2 7.4e-06 26.7 0.2 1.4 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.7 ELR16643.1 - 2.3e-05 24.2 0.0 4.2e-05 23.4 0.0 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family DLH PF01738.18 ELR16643.1 - 0.0004 20.0 0.0 0.00057 19.5 0.0 1.3 1 0 0 1 1 1 1 Dienelactone hydrolase family VirJ PF06057.11 ELR16643.1 - 0.001 19.0 0.0 0.0019 18.1 0.0 1.5 1 0 0 1 1 1 1 Bacterial virulence protein (VirJ) Abhydrolase_1 PF00561.20 ELR16643.1 - 0.0012 18.5 0.0 0.0018 18.0 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_3 PF07859.13 ELR16643.1 - 0.0024 17.8 0.0 0.003 17.5 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Lipase_3 PF01764.25 ELR16643.1 - 0.0027 17.6 1.4 0.0043 16.9 0.0 1.9 2 0 0 2 2 2 1 Lipase (class 3) Thioesterase PF00975.20 ELR16643.1 - 0.012 15.7 0.0 0.064 13.4 0.0 1.9 2 0 0 2 2 2 0 Thioesterase domain DUF915 PF06028.11 ELR16643.1 - 0.061 12.6 0.0 0.09 12.1 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF915) FSH1 PF03959.13 ELR16643.1 - 0.08 12.6 0.0 0.26 10.9 0.0 1.8 1 1 0 1 1 1 0 Serine hydrolase (FSH1) AXE1 PF05448.12 ELR16643.1 - 0.09 11.4 0.2 0.15 10.7 0.2 1.3 1 0 0 1 1 1 0 Acetyl xylan esterase (AXE1) Abhydrolase_2 PF02230.16 ELR16643.1 - 0.11 12.3 0.0 0.22 11.3 0.0 1.6 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase PGAP1 PF07819.13 ELR16643.1 - 0.15 11.8 0.0 0.27 10.9 0.0 1.4 1 0 0 1 1 1 0 PGAP1-like protein DUF2838 PF10998.8 ELR16644.1 - 4.1e-42 142.9 9.9 4.1e-42 142.9 9.9 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF2838) PIP5K PF01504.18 ELR16645.1 - 2.8e-75 253.1 0.0 4.5e-75 252.4 0.0 1.3 1 0 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase Ank_2 PF12796.7 ELR16645.1 - 2.4e-35 121.0 0.6 1.3e-12 48.1 0.0 3.1 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ELR16645.1 - 6.3e-31 106.4 0.6 4.5e-14 52.6 0.1 4.4 2 2 2 4 4 4 4 Ankyrin repeats (many copies) Ank_5 PF13857.6 ELR16645.1 - 8.9e-25 86.4 1.3 1.2e-10 41.4 0.0 3.8 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 ELR16645.1 - 1.3e-24 83.6 1.4 4.6e-05 23.5 0.0 5.5 5 0 0 5 5 5 4 Ankyrin repeat Ank PF00023.30 ELR16645.1 - 3.7e-24 84.0 2.5 0.00079 19.8 0.0 5.8 5 0 0 5 5 5 4 Ankyrin repeat C1_1 PF00130.22 ELR16645.1 - 4.6e-08 32.8 6.0 9.4e-08 31.8 6.0 1.6 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) EF-hand_6 PF13405.6 ELR16645.1 - 4.5e-06 26.2 2.8 0.00053 19.7 0.2 4.2 4 0 0 4 4 4 1 EF-hand domain EF-hand_1 PF00036.32 ELR16645.1 - 5e-06 25.7 4.0 0.0033 16.9 0.7 4.7 4 0 0 4 4 4 1 EF hand EF-hand_7 PF13499.6 ELR16645.1 - 2.8e-05 24.5 0.1 0.085 13.3 0.1 3.0 2 0 0 2 2 2 2 EF-hand domain pair C1_2 PF03107.16 ELR16645.1 - 0.0022 18.3 3.4 0.0056 17.0 3.4 1.7 1 0 0 1 1 1 1 C1 domain Zn_ribbon_17 PF17120.5 ELR16645.1 - 0.12 12.0 4.1 0.3 10.7 4.1 1.7 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type EF-hand_5 PF13202.6 ELR16645.1 - 0.5 10.0 4.1 0.77 9.4 0.3 2.9 2 0 0 2 2 2 0 EF hand EGF PF00008.27 ELR16646.1 - 1.6 9.1 6.9 0.74 10.2 0.5 2.6 2 1 0 2 2 2 0 EGF-like domain SLC35F PF06027.12 ELR16647.1 - 7e-08 32.3 7.2 7e-08 32.3 7.2 2.5 3 1 0 3 3 3 1 Solute carrier family 35 EamA PF00892.20 ELR16647.1 - 7.1e-06 26.2 1.5 7.1e-06 26.2 1.5 4.1 4 1 1 5 5 5 1 EamA-like transporter family CRT-like PF08627.10 ELR16647.1 - 3.8e-05 22.8 11.8 3.8e-05 22.8 11.8 3.4 2 1 2 4 4 4 1 CRT-like, chloroquine-resistance transporter-like PUNUT PF16913.5 ELR16647.1 - 0.0051 16.1 2.0 0.0051 16.1 2.0 2.7 3 0 0 3 3 3 1 Purine nucleobase transmembrane transport COX4 PF02936.14 ELR16647.1 - 0.21 11.6 0.1 3.8 7.5 0.0 2.5 1 1 1 2 2 2 0 Cytochrome c oxidase subunit IV PMP1_2 PF08114.11 ELR16647.1 - 2.5 7.9 8.4 25 4.7 1.9 3.8 3 0 0 3 3 3 0 ATPase proteolipid family Wzy_C PF04932.15 ELR16647.1 - 3.2 7.3 15.0 20 4.8 0.0 3.2 2 1 0 2 2 2 0 O-Antigen ligase CBS PF00571.28 ELR16648.1 - 1e-24 86.7 4.8 2.6e-05 24.6 0.1 6.0 5 1 0 5 5 5 5 CBS domain PRC PF05239.16 ELR16648.1 - 0.077 13.1 0.0 5 7.3 0.0 2.4 2 0 0 2 2 2 0 PRC-barrel domain Beta-lactamase PF00144.24 ELR16649.1 - 9.8e-42 143.3 0.1 1.5e-41 142.8 0.1 1.2 1 0 0 1 1 1 1 Beta-lactamase Peptidase_S11 PF00768.20 ELR16649.1 - 0.041 13.3 0.0 0.097 12.1 0.0 1.5 2 0 0 2 2 2 0 D-alanyl-D-alanine carboxypeptidase Mad3_BUB1_I PF08311.12 ELR16651.1 - 6.3e-29 100.5 1.3 1.8e-28 99.0 1.3 1.8 1 1 0 1 1 1 1 Mad3/BUB1 homology region 1 TetR_C_6 PF13977.6 ELR16651.1 - 0.23 11.7 2.2 0.28 11.4 0.1 2.3 3 0 0 3 3 3 0 BetI-type transcriptional repressor, C-terminal Pkinase_Tyr PF07714.17 ELR16652.1 - 1.4e-121 404.7 0.0 1.8e-60 204.4 0.0 2.4 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 ELR16652.1 - 9.7e-105 349.7 0.0 1.1e-53 182.3 0.0 2.3 2 0 0 2 2 2 2 Protein kinase domain PBP_like_2 PF12849.7 ELR16652.1 - 3.1e-24 86.1 14.4 8.9e-12 45.3 8.3 2.4 2 0 0 2 2 2 2 PBP superfamily domain Guanylate_cyc PF00211.20 ELR16652.1 - 1.3e-12 47.7 0.0 2.4e-12 46.9 0.0 1.4 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain APH PF01636.23 ELR16652.1 - 4.3e-07 30.1 2.5 0.00012 22.1 0.0 3.2 3 1 1 4 4 4 2 Phosphotransferase enzyme family Haspin_kinase PF12330.8 ELR16652.1 - 0.00049 19.2 0.0 0.096 11.6 0.0 2.8 3 0 0 3 3 3 1 Haspin like kinase domain FTA2 PF13095.6 ELR16652.1 - 0.0011 18.6 0.0 2 8.0 0.0 3.6 3 1 1 4 4 4 1 Kinetochore Sim4 complex subunit FTA2 Kinase-like PF14531.6 ELR16652.1 - 0.0013 18.1 0.0 0.31 10.3 0.0 2.5 3 0 0 3 3 3 1 Kinase-like Pkinase_fungal PF17667.1 ELR16652.1 - 0.0015 17.4 0.0 0.15 10.8 0.0 2.2 2 0 0 2 2 2 1 Fungal protein kinase Kdo PF06293.14 ELR16652.1 - 0.045 13.1 0.1 6.1 6.1 0.0 2.3 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family TauE PF01925.19 ELR16652.1 - 0.046 13.3 2.6 0.071 12.7 0.2 2.5 2 0 0 2 2 2 0 Sulfite exporter TauE/SafE EGF_2 PF07974.13 ELR16652.1 - 0.19 12.1 9.0 0.38 11.2 9.0 1.5 1 0 0 1 1 1 0 EGF-like domain Flp_Fap PF04964.14 ELR16652.1 - 0.27 11.1 1.4 29 4.6 0.3 3.1 2 0 0 2 2 2 0 Flp/Fap pilin component EGF_Tenascin PF18720.1 ELR16652.1 - 0.29 11.2 4.8 0.63 10.2 4.8 1.5 1 0 0 1 1 1 0 Tenascin EGF domain MutS_V PF00488.21 ELR16653.1 - 4.1e-62 209.6 0.5 1.3e-61 207.9 0.5 1.8 1 1 0 1 1 1 1 MutS domain V MutS_III PF05192.18 ELR16653.1 - 4.6e-37 128.1 0.0 8.5e-37 127.2 0.0 1.5 1 0 0 1 1 1 1 MutS domain III MutS_I PF01624.20 ELR16653.1 - 1.1e-27 96.5 0.0 2.1e-27 95.6 0.0 1.5 1 0 0 1 1 1 1 MutS domain I MutS_II PF05188.17 ELR16653.1 - 6.2e-13 49.2 0.3 2.6e-12 47.2 0.3 2.0 1 1 0 1 1 1 1 MutS domain II MutS_IV PF05190.18 ELR16653.1 - 1.6e-08 34.8 0.0 3.3e-08 33.7 0.0 1.6 1 0 0 1 1 1 1 MutS family domain IV zf-GRF PF06839.12 ELR16653.1 - 0.0067 16.5 0.0 0.013 15.5 0.0 1.5 1 0 0 1 1 1 1 GRF zinc finger AAA_23 PF13476.6 ELR16653.1 - 0.13 12.7 0.2 1.7 9.1 0.0 2.6 3 0 0 3 3 3 0 AAA domain Pkinase_Tyr PF07714.17 ELR16654.1 - 2.9e-124 413.5 0.0 4.8e-63 212.9 0.0 2.5 3 0 0 3 3 3 2 Protein tyrosine kinase Pkinase PF00069.25 ELR16654.1 - 9.2e-107 356.3 0.0 7.4e-55 186.1 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain PBP_like_2 PF12849.7 ELR16654.1 - 3.1e-25 89.4 23.0 3.5e-16 59.7 7.1 2.5 3 0 0 3 3 2 2 PBP superfamily domain APH PF01636.23 ELR16654.1 - 4.4e-07 30.1 1.0 0.00025 21.0 0.0 2.9 2 1 0 2 2 2 2 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 ELR16654.1 - 7.7e-06 24.9 0.0 0.032 13.0 0.0 2.2 2 0 0 2 2 2 2 Fungal protein kinase Guanylate_cyc PF00211.20 ELR16654.1 - 6.2e-05 22.7 0.0 0.00011 21.8 0.0 1.3 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain Haspin_kinase PF12330.8 ELR16654.1 - 0.0015 17.5 0.0 0.03 13.3 0.0 2.6 3 0 0 3 3 3 1 Haspin like kinase domain FTA2 PF13095.6 ELR16654.1 - 0.002 17.8 0.0 0.29 10.7 0.0 3.3 3 1 1 4 4 4 1 Kinetochore Sim4 complex subunit FTA2 Kinase-like PF14531.6 ELR16654.1 - 0.0036 16.6 0.0 0.34 10.2 0.0 2.5 2 0 0 2 2 2 1 Kinase-like EGF_Tenascin PF18720.1 ELR16654.1 - 0.098 12.7 7.2 0.22 11.6 7.2 1.6 1 0 0 1 1 1 0 Tenascin EGF domain EGF_2 PF07974.13 ELR16654.1 - 0.1 12.9 11.9 0.19 12.1 11.9 1.4 1 0 0 1 1 1 0 EGF-like domain Kdo PF06293.14 ELR16654.1 - 0.13 11.6 0.2 14 4.9 0.0 2.3 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family SQS_PSY PF00494.19 ELR16656.1 - 2.4e-45 155.1 0.0 3e-45 154.8 0.0 1.1 1 0 0 1 1 1 1 Squalene/phytoene synthase zf-UBR PF02207.20 ELR16657.1 - 1.4e-08 34.7 15.5 2.2e-08 34.2 15.5 1.2 1 0 0 1 1 1 1 Putative zinc finger in N-recognin (UBR box) UBA PF00627.31 ELR16657.1 - 1.2e-06 28.3 0.0 2.2e-06 27.4 0.0 1.5 1 0 0 1 1 1 1 UBA/TS-N domain Bclt PF15318.6 ELR16657.1 - 0.005 16.7 0.5 0.94 9.3 0.0 2.3 2 0 0 2 2 2 2 Putative Bcl-2 like protein of testis ubiquitin PF00240.23 ELR16657.1 - 0.022 14.5 0.3 0.085 12.6 0.3 1.9 1 1 0 1 1 1 0 Ubiquitin family Pkinase_Tyr PF07714.17 ELR16658.1 - 1.7e-120 401.1 0.0 2.7e-62 210.4 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 ELR16658.1 - 7.1e-104 346.8 0.0 1.2e-53 182.2 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain PBP_like_2 PF12849.7 ELR16658.1 - 1.4e-17 64.3 3.6 4.4e-11 43.0 0.2 2.8 2 1 0 2 2 2 2 PBP superfamily domain Guanylate_cyc PF00211.20 ELR16658.1 - 2.7e-13 50.0 0.0 5.1e-13 49.0 0.0 1.4 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain APH PF01636.23 ELR16658.1 - 1.4e-06 28.4 0.4 0.00069 19.6 0.0 2.6 2 0 0 2 2 2 2 Phosphotransferase enzyme family Haspin_kinase PF12330.8 ELR16658.1 - 0.00035 19.6 0.0 0.026 13.5 0.0 2.2 2 0 0 2 2 2 1 Haspin like kinase domain Pkinase_fungal PF17667.1 ELR16658.1 - 0.00041 19.3 0.0 0.16 10.7 0.0 2.2 2 0 0 2 2 2 2 Fungal protein kinase Kinase-like PF14531.6 ELR16658.1 - 0.0041 16.5 0.0 0.051 12.9 0.0 2.1 2 0 0 2 2 2 1 Kinase-like FTA2 PF13095.6 ELR16658.1 - 0.015 14.9 0.0 2.1 7.9 0.0 3.0 3 0 0 3 3 3 0 Kinetochore Sim4 complex subunit FTA2 EGF_2 PF07974.13 ELR16658.1 - 0.064 13.6 8.7 0.12 12.8 8.7 1.4 1 0 0 1 1 1 0 EGF-like domain Kdo PF06293.14 ELR16658.1 - 0.15 11.4 0.2 18 4.6 0.0 2.4 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family DUF4229 PF14012.6 ELR16658.1 - 1.5 9.0 5.5 0.82 9.8 0.3 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF4229) Glycos_transf_2 PF00535.26 ELR16659.1 - 0.013 15.3 0.1 0.068 13.0 0.1 2.0 1 1 0 1 1 1 0 Glycosyl transferase family 2 Glyco_trans_2_3 PF13632.6 ELR16659.1 - 0.23 11.3 3.5 0.74 9.7 0.0 2.2 2 0 0 2 2 2 0 Glycosyl transferase family group 2 TM2 PF05154.16 ELR16660.1 - 4.9e-07 30.0 0.2 4.9e-07 30.0 0.2 2.7 3 0 0 3 3 3 1 TM2 domain DUF3844 PF12955.7 ELR16660.1 - 0.026 14.7 2.8 0.026 14.7 2.8 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF3844) Laminin_EGF PF00053.24 ELR16660.1 - 0.032 14.4 6.2 0.032 14.4 6.2 2.5 2 2 1 3 3 3 0 Laminin EGF domain PIRT PF15099.6 ELR16660.1 - 0.074 12.6 0.0 0.11 12.1 0.0 1.4 1 1 0 1 1 1 0 Phosphoinositide-interacting protein family Ldh_2 PF02615.14 ELR16661.1 - 1.6e-100 336.6 0.1 1.8e-100 336.4 0.1 1.0 1 0 0 1 1 1 1 Malate/L-lactate dehydrogenase RGS PF00615.19 ELR16662.1 - 4.4e-22 78.6 2.5 6.6e-22 78.0 2.5 1.3 1 0 0 1 1 1 1 Regulator of G protein signaling domain LIM PF00412.22 ELR16662.1 - 3.1e-07 30.5 20.0 0.00056 20.1 8.3 3.2 3 0 0 3 3 3 2 LIM domain Gluconate_2-dh3 PF13618.6 ELR16662.1 - 0.11 12.8 0.0 0.19 11.9 0.0 1.3 1 0 0 1 1 1 0 Gluconate 2-dehydrogenase subunit 3 DUF2175 PF09943.9 ELR16662.1 - 1.4 9.2 6.0 0.98 9.8 1.4 2.4 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2175) zf-RRN7 PF11781.8 ELR16662.1 - 5 6.9 7.1 0.32 10.7 1.3 2.1 2 0 0 2 2 2 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 Auto_anti-p27 PF06677.12 ELR16662.1 - 8.6 6.6 16.2 3.1 8.0 1.9 3.3 3 0 0 3 3 3 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) Sugar_tr PF00083.24 ELR16663.1 - 1.8e-35 122.7 8.7 1.6e-29 103.1 0.7 2.3 2 1 0 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 ELR16663.1 - 4.2e-33 114.7 35.4 4.2e-32 111.4 27.3 2.5 1 1 1 2 2 2 2 Major Facilitator Superfamily Pirin PF02678.16 ELR16664.1 - 2.3e-27 95.1 1.0 6.4e-27 93.7 0.9 1.7 2 0 0 2 2 2 1 Pirin Pirin_C_2 PF17954.1 ELR16664.1 - 5.2e-10 39.4 0.1 4.2e-09 36.4 0.0 2.1 2 0 0 2 2 2 1 Quercetinase C-terminal cupin domain Cupin_2 PF07883.11 ELR16664.1 - 1.2e-09 37.7 2.1 7.9e-05 22.3 0.7 2.3 2 0 0 2 2 2 2 Cupin domain Ependymin PF00811.18 ELR16665.1 - 0.077 13.3 0.8 0.19 12.0 0.7 1.7 1 1 1 2 2 2 0 Ependymin Beta-lactamase PF00144.24 ELR16666.1 - 1.2e-41 143.1 0.0 2.1e-41 142.3 0.0 1.3 1 0 0 1 1 1 1 Beta-lactamase Peptidase_S11 PF00768.20 ELR16666.1 - 0.015 14.7 0.0 0.067 12.6 0.0 1.8 2 0 0 2 2 2 0 D-alanyl-D-alanine carboxypeptidase Amidohydro_3 PF07969.11 ELR16667.1 - 2.5e-87 294.4 9.3 2.8e-87 294.1 9.3 1.0 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_1 PF01979.20 ELR16667.1 - 4.3e-15 55.9 0.1 8.8e-11 41.7 0.0 2.4 2 1 0 2 2 2 2 Amidohydrolase family vATP-synt_E PF01991.18 ELR16668.1 - 1.6e-62 210.4 9.2 2e-62 210.2 9.2 1.1 1 0 0 1 1 1 1 ATP synthase (E/31 kDa) subunit Cas_DxTHG PF09455.10 ELR16668.1 - 0.58 9.7 4.3 0.64 9.5 4.3 1.1 1 0 0 1 1 1 0 CRISPR-associated (Cas) DxTHG family Alpha-amylase PF00128.24 ELR16668.1 - 0.92 9.0 4.6 1.7 8.2 2.4 1.9 2 0 0 2 2 2 0 Alpha amylase, catalytic domain FAD_binding_3 PF01494.19 ELR16669.1 - 1.6e-23 83.5 1.1 3.8e-22 79.0 1.1 2.2 1 1 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.6 ELR16669.1 - 0.00025 21.2 0.1 0.0006 20.0 0.1 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 ELR16669.1 - 0.00044 19.9 1.1 0.00044 19.9 1.1 1.8 2 1 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 ELR16669.1 - 0.00061 19.1 0.4 0.045 13.0 0.3 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 ELR16669.1 - 0.0095 15.1 0.5 0.021 13.9 0.5 1.6 1 0 0 1 1 1 1 FAD binding domain Pyr_redox PF00070.27 ELR16669.1 - 0.049 14.2 0.3 0.41 11.2 0.1 2.3 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 ELR16669.1 - 0.16 11.0 3.5 1.9 7.4 0.1 3.0 3 0 0 3 3 3 0 Lycopene cyclase protein GIDA PF01134.22 ELR16669.1 - 0.19 10.8 0.6 0.28 10.2 0.6 1.2 1 0 0 1 1 1 0 Glucose inhibited division protein A 2OG-FeII_Oxy_2 PF13532.6 ELR16670.1 - 2.3e-27 96.5 0.0 2.7e-27 96.2 0.0 1.1 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily SSFA2_C PF14723.6 ELR16670.1 - 0.47 10.3 1.7 0.67 9.8 1.1 1.5 1 1 1 2 2 2 0 Sperm-specific antigen 2 C-terminus DUF4407 PF14362.6 ELR16671.1 - 0.39 10.0 11.1 0.48 9.7 11.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Ureide_permease PF07168.11 ELR16671.1 - 1.9 7.1 2.9 2.6 6.7 2.9 1.1 1 0 0 1 1 1 0 Ureide permease Presenilin PF01080.17 ELR16671.1 - 3.1 6.5 14.0 3.6 6.3 14.0 1.2 1 0 0 1 1 1 0 Presenilin SLC12 PF03522.15 ELR16671.1 - 3.2 6.7 8.7 3.7 6.5 8.7 1.1 1 0 0 1 1 1 0 Solute carrier family 12 DUF5427 PF10310.9 ELR16671.1 - 4.9 6.0 18.2 5.8 5.7 18.2 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5427) MCM_bind PF09739.9 ELR16671.1 - 7.4 4.9 10.7 8.6 4.7 10.7 1.2 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor XRN_N PF03159.18 ELR16672.1 - 1.3e-06 28.1 0.0 2.4e-06 27.1 0.0 1.3 1 0 0 1 1 1 1 XRN 5'-3' exonuclease N-terminus XRN_M PF17846.1 ELR16672.1 - 0.00091 18.3 0.2 0.095 11.6 0.0 2.2 2 0 0 2 2 2 2 Xrn1 helical domain XPG_I PF00867.18 ELR16672.1 - 0.11 12.9 0.1 0.31 11.4 0.1 1.6 1 1 0 1 1 1 0 XPG I-region Ank_2 PF12796.7 ELR16673.1 - 2.7e-24 85.5 1.1 1.3e-09 38.5 0.5 3.5 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ELR16673.1 - 5.5e-21 74.6 1.4 1.7e-10 41.2 0.2 4.5 2 2 3 5 5 5 5 Ankyrin repeats (many copies) Ank_5 PF13857.6 ELR16673.1 - 2.4e-20 72.3 6.4 2.4e-10 40.4 0.3 5.0 3 1 2 5 5 5 5 Ankyrin repeats (many copies) Ank PF00023.30 ELR16673.1 - 5.2e-20 70.9 8.7 0.00025 21.3 0.1 5.6 5 0 0 5 5 5 4 Ankyrin repeat Ank_3 PF13606.6 ELR16673.1 - 9.5e-20 68.6 0.8 0.0032 17.8 0.0 5.7 5 0 0 5 5 5 4 Ankyrin repeat Ras PF00071.22 ELR16673.1 - 1e-18 67.5 0.0 1.7e-18 66.8 0.0 1.3 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR16673.1 - 3.6e-12 46.5 0.0 7.4e-12 45.5 0.0 1.6 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase F-box-like PF12937.7 ELR16673.1 - 4.2e-05 23.3 1.5 0.00028 20.7 1.5 2.3 1 1 0 1 1 1 1 F-box-like TPT PF03151.16 ELR16674.1 - 7.3e-24 84.6 17.1 8.4e-24 84.4 17.1 1.0 1 0 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 ELR16674.1 - 7.4e-06 26.2 30.9 0.00022 21.4 16.7 2.6 2 1 0 2 2 2 2 EamA-like transporter family Ilm1 PF10311.9 ELR16674.1 - 5.5 6.6 6.9 1.1 8.8 2.2 2.1 2 0 0 2 2 2 0 Increased loss of mitochondrial DNA protein 1 SecE PF00584.20 ELR16675.1 - 4e-16 58.7 0.3 5.4e-16 58.3 0.3 1.2 1 0 0 1 1 1 1 SecE/Sec61-gamma subunits of protein translocation complex CbtB PF09489.10 ELR16675.1 - 0.037 14.1 0.0 0.05 13.7 0.0 1.2 1 0 0 1 1 1 0 Probable cobalt transporter subunit (CbtB) Ubiquitin_4 PF18036.1 ELR16676.1 - 1.3e-14 54.0 0.0 2e-14 53.4 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-like domain ubiquitin PF00240.23 ELR16676.1 - 0.013 15.2 0.2 0.76 9.6 0.0 2.3 2 0 0 2 2 2 0 Ubiquitin family Kelch_6 PF13964.6 ELR16677.1 - 2.1e-38 129.3 7.6 5.5e-08 32.8 0.1 6.4 5 1 1 6 6 6 6 Kelch motif Kelch_1 PF01344.25 ELR16677.1 - 1.6e-34 117.2 11.2 2.4e-08 33.4 0.0 6.5 6 0 0 6 6 6 5 Kelch motif Kelch_4 PF13418.6 ELR16677.1 - 6.8e-32 109.2 7.6 2.9e-07 30.4 0.1 6.5 5 1 1 6 6 6 6 Galactose oxidase, central domain Kelch_2 PF07646.15 ELR16677.1 - 1.5e-31 107.2 14.5 2.6e-10 39.8 0.0 6.4 6 0 0 6 6 6 6 Kelch motif Kelch_5 PF13854.6 ELR16677.1 - 1.2e-27 95.4 13.6 5.9e-06 26.1 0.0 6.5 6 0 0 6 6 6 5 Kelch motif Kelch_3 PF13415.6 ELR16677.1 - 3.2e-27 94.2 3.8 9e-05 22.7 0.0 7.5 7 0 0 7 7 7 5 Galactose oxidase, central domain BTB PF00651.31 ELR16677.1 - 1.7e-08 34.7 0.9 0.02 15.1 0.0 3.7 4 0 0 4 4 4 2 BTB/POZ domain MAM1 PF10434.9 ELR16677.1 - 0.16 11.5 3.9 0.24 11.0 3.9 1.1 1 0 0 1 1 1 0 Monopolin complex protein MAM1 AP3D1 PF06375.11 ELR16677.1 - 0.35 11.1 11.9 0.67 10.2 11.9 1.5 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 DUF3464 PF11947.8 ELR16677.1 - 0.59 9.9 2.7 1.2 8.9 2.7 1.4 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 DUF1666 PF07891.12 ELR16677.1 - 0.65 9.6 7.6 1 9.0 7.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1666) DUF2828 PF11443.8 ELR16677.1 - 0.86 7.6 4.7 1.2 7.1 4.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) LYRIC PF15686.5 ELR16677.1 - 0.9 9.0 12.8 1.3 8.5 12.8 1.1 1 0 0 1 1 1 0 Lysine-rich CEACAM1 co-isolated protein family FAM176 PF14851.6 ELR16677.1 - 0.91 9.2 4.6 1.1 8.9 3.3 1.7 2 0 0 2 2 2 0 FAM176 family GAGA_bind PF06217.12 ELR16677.1 - 1.1 9.5 7.1 1.7 8.9 7.1 1.2 1 0 0 1 1 1 0 GAGA binding protein-like family Pannexin_like PF12534.8 ELR16677.1 - 1.3 8.0 3.2 1.9 7.5 3.2 1.1 1 0 0 1 1 1 0 Pannexin-like TM region of LRRC8 DUF5327 PF17261.2 ELR16677.1 - 1.8 9.3 6.6 3.3 8.5 6.6 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5327) Coilin_N PF15862.5 ELR16677.1 - 3.9 7.3 9.7 6.7 6.5 9.7 1.3 1 0 0 1 1 1 0 Coilin N-terminus Peptidase_S49_N PF08496.10 ELR16677.1 - 5.6 7.0 8.3 14 5.8 8.3 1.6 1 0 0 1 1 1 0 Peptidase family S49 N-terminal Vps5 PF09325.10 ELR16678.1 - 0.45 10.0 7.0 4.2 6.9 7.0 2.0 1 1 0 1 1 1 0 Vps5 C terminal like MRG PF05712.13 ELR16679.1 - 1.1e-36 126.0 0.0 1.5e-36 125.6 0.0 1.2 1 0 0 1 1 1 1 MRG SSP160 PF06933.11 ELR16680.1 - 2.7 6.1 3.2 3.1 5.9 3.2 1.0 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 M16C_assoc PF08367.11 ELR16681.1 - 2e-71 240.1 0.1 5.5e-71 238.6 0.1 1.8 1 1 0 1 1 1 1 Peptidase M16C associated Peptidase_M16_C PF05193.21 ELR16681.1 - 2.7e-28 99.2 0.0 1.3e-20 74.2 0.0 2.7 2 0 0 2 2 2 2 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 ELR16681.1 - 1.1e-09 38.4 0.0 1.8e-08 34.5 0.0 2.8 2 1 0 2 2 2 1 Insulinase (Peptidase family M16) DUF1690 PF07956.11 ELR16681.1 - 0.11 12.9 1.3 11 6.4 0.0 2.5 2 0 0 2 2 2 0 Protein of Unknown function (DUF1690) XPG_I PF00867.18 ELR16683.1 - 5.8e-29 100.3 0.0 1e-28 99.5 0.0 1.4 1 0 0 1 1 1 1 XPG I-region XPG_N PF00752.17 ELR16683.1 - 1.9e-16 60.4 0.0 3.1e-16 59.7 0.0 1.3 1 0 0 1 1 1 1 XPG N-terminal domain 5_3_exonuc PF01367.20 ELR16683.1 - 3.9e-07 30.6 0.0 8e-07 29.6 0.0 1.5 1 0 0 1 1 1 1 5'-3' exonuclease, C-terminal SAM fold HHH_5 PF14520.6 ELR16683.1 - 0.0029 18.2 0.0 0.0096 16.5 0.0 1.9 2 0 0 2 2 2 1 Helix-hairpin-helix domain RICTOR_N PF14664.6 ELR16684.1 - 1.4e-30 106.5 0.2 4.2e-29 101.7 0.0 2.3 2 0 0 2 2 2 1 Rapamycin-insensitive companion of mTOR, N-term RICTOR_V PF14668.6 ELR16684.1 - 7.1e-27 93.4 0.5 3.5e-24 84.8 0.1 3.4 3 0 0 3 3 3 1 Rapamycin-insensitive companion of mTOR, domain 5 RasGEF_N_2 PF14663.6 ELR16684.1 - 2.9e-21 75.9 0.0 9.7e-21 74.2 0.0 2.0 1 0 0 1 1 1 1 Rapamycin-insensitive companion of mTOR RasGEF_N domain RICTOR_M PF14666.6 ELR16684.1 - 1.3e-11 44.2 0.0 6.3e-09 35.5 0.0 4.0 3 1 1 4 4 4 1 Rapamycin-insensitive companion of mTOR, middle domain MMS19_N PF14500.6 ELR16684.1 - 0.078 12.5 0.0 0.19 11.3 0.0 1.6 1 0 0 1 1 1 0 Dos2-interacting transcription regulator of RNA-Pol-II Glyco_hydro_2_C PF02836.17 ELR16685.1 - 1e-81 274.3 0.5 1.3e-81 274.0 0.5 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain Glyco_hydro_2 PF00703.21 ELR16685.1 - 0.00019 22.1 0.0 0.00033 21.3 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 2 Glyco_hydro_72 PF03198.14 ELR16685.1 - 0.00067 19.0 0.3 0.64 9.2 0.0 2.2 2 0 0 2 2 2 2 Glucanosyltransferase Glyco_hydro_53 PF07745.13 ELR16685.1 - 0.0027 16.8 0.1 0.0042 16.1 0.1 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 53 Cellulase PF00150.18 ELR16685.1 - 0.034 13.6 0.4 0.1 12.0 0.4 1.8 1 1 0 1 1 1 0 Cellulase (glycosyl hydrolase family 5) DUF4434 PF14488.6 ELR16685.1 - 0.16 12.0 0.1 0.32 11.0 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4434) WD40 PF00400.32 ELR16686.1 - 7.9e-41 137.3 28.1 4.4e-10 40.0 1.0 6.4 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ELR16686.1 - 1.3e-07 31.8 1.7 0.021 15.1 0.3 4.2 1 1 3 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ELR16686.1 - 1.4e-06 27.6 8.8 0.5 9.3 0.1 5.1 1 1 3 5 5 5 3 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 ELR16686.1 - 3.3e-05 23.7 2.4 26 4.9 0.0 6.0 6 0 0 6 6 6 0 WD40-like Beta Propeller Repeat Invasin_D3 PF09134.10 ELR16686.1 - 0.0087 16.4 0.9 0.83 10.0 0.0 2.6 2 1 0 2 2 2 1 Invasin, domain 3 Str_synth PF03088.16 ELR16686.1 - 0.0096 16.0 0.5 0.46 10.7 0.0 3.3 3 2 1 4 4 4 1 Strictosidine synthase Gmad1 PF10647.9 ELR16686.1 - 0.079 12.7 6.2 0.74 9.5 0.2 3.6 1 1 2 4 4 4 0 Lipoprotein LpqB beta-propeller domain Nup160 PF11715.8 ELR16686.1 - 0.17 10.5 4.2 15 4.0 0.1 3.7 2 1 2 4 4 4 0 Nucleoporin Nup120/160 NACHT PF05729.12 ELR16687.1 - 0.0001 22.3 0.0 0.00015 21.7 0.0 1.3 1 0 0 1 1 1 1 NACHT domain AAA_16 PF13191.6 ELR16687.1 - 0.08 13.3 0.1 0.21 12.0 0.1 1.7 2 0 0 2 2 2 0 AAA ATPase domain PilJ PF13675.6 ELR16687.1 - 0.081 13.0 0.0 15 5.6 0.0 2.3 2 0 0 2 2 2 0 Type IV pili methyl-accepting chemotaxis transducer N-term Glyco_hydro_2_N PF02837.18 ELR16688.1 - 3.3e-24 85.7 0.1 6.7e-24 84.7 0.1 1.6 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, sugar binding domain Glyco_hydro_2_C PF02836.17 ELR16688.1 - 2.6e-22 79.3 0.0 3.8e-22 78.8 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain Glyco_hydro_2 PF00703.21 ELR16688.1 - 1.4e-05 25.7 0.1 3.8e-05 24.3 0.1 1.7 1 1 0 1 1 1 1 Glycosyl hydrolases family 2 Glyco_hydro_53 PF07745.13 ELR16688.1 - 0.11 11.4 0.0 0.18 10.8 0.0 1.3 1 0 0 1 1 1 0 Glycosyl hydrolase family 53 WD40 PF00400.32 ELR16689.1 - 2.2e-30 104.3 18.3 0.00014 22.5 0.1 7.4 7 0 0 7 7 7 7 WD domain, G-beta repeat F-box-like PF12937.7 ELR16689.1 - 2.1e-12 46.7 0.3 5.7e-12 45.3 0.2 1.8 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 ELR16689.1 - 4.2e-08 32.9 0.2 4.2e-08 32.9 0.2 2.0 2 0 0 2 2 2 1 F-box domain PQQ_3 PF13570.6 ELR16689.1 - 0.015 15.7 4.7 0.62 10.6 0.2 3.6 3 0 0 3 3 3 0 PQQ-like domain DUF1939 PF09154.10 ELR16689.1 - 0.077 13.2 0.3 0.2 11.8 0.3 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF1939) LssY_C PF14067.6 ELR16689.1 - 0.094 12.3 1.7 5 6.6 0.0 2.4 1 1 1 2 2 2 0 LssY C-terminus Tox-SGS PF15651.6 ELR16689.1 - 0.094 13.0 0.0 3.8 7.8 0.0 2.4 2 0 0 2 2 2 0 Salivary glad secreted protein domain toxin GrlR PF16518.5 ELR16689.1 - 0.1 12.5 0.1 0.32 11.0 0.1 1.9 1 0 0 1 1 1 0 T3SS negative regulator,GrlR PAC2 PF09754.9 ELR16690.1 - 5.9e-21 75.5 0.0 7.8e-21 75.1 0.0 1.1 1 0 0 1 1 1 1 PAC2 family Methyltransf_16 PF10294.9 ELR16691.1 - 1.9e-31 109.1 0.0 2.5e-31 108.7 0.0 1.1 1 0 0 1 1 1 1 Lysine methyltransferase MTS PF05175.14 ELR16691.1 - 0.0002 21.0 0.0 0.00048 19.7 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase small domain GidB PF02527.15 ELR16691.1 - 0.035 13.4 0.0 0.058 12.7 0.0 1.3 1 0 0 1 1 1 0 rRNA small subunit methyltransferase G Herpes_capsid PF06112.11 ELR16691.1 - 0.19 11.8 0.0 0.32 11.1 0.0 1.3 1 0 0 1 1 1 0 Gammaherpesvirus capsid protein Pkinase PF00069.25 ELR16692.1 - 9.7e-70 234.9 0.0 1.3e-69 234.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR16692.1 - 6.8e-50 169.8 0.0 9.7e-50 169.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ELR16692.1 - 2.3e-06 27.2 0.0 0.0026 17.1 0.0 2.3 2 0 0 2 2 2 2 Kinase-like Pkinase_fungal PF17667.1 ELR16692.1 - 1.6e-05 23.9 0.0 2.7e-05 23.1 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Haspin_kinase PF12330.8 ELR16692.1 - 0.00026 20.1 0.3 0.0011 18.1 0.3 1.7 1 1 0 1 1 1 1 Haspin like kinase domain TTL PF03133.15 ELR16693.1 - 4.1e-53 180.4 0.9 8.9e-53 179.3 0.9 1.5 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family ATPgrasp_ST PF14397.6 ELR16693.1 - 0.027 13.7 0.0 0.058 12.6 0.0 1.5 1 0 0 1 1 1 0 Sugar-transfer associated ATP-grasp CX9C PF16860.5 ELR16694.1 - 0.0001 22.2 0.7 0.00089 19.2 0.0 2.2 2 0 0 2 2 2 1 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, WAC_Acf1_DNA_bd PF10537.9 ELR16694.1 - 0.05 14.1 0.0 0.11 13.1 0.0 1.5 1 1 0 1 1 1 0 ATP-utilising chromatin assembly and remodelling N-terminal Cmc1 PF08583.10 ELR16694.1 - 0.12 12.5 5.7 0.6 10.2 0.7 3.0 1 1 1 2 2 2 0 Cytochrome c oxidase biogenesis protein Cmc1 like Pet191_N PF10203.9 ELR16694.1 - 0.16 12.3 3.7 0.58 10.5 2.3 2.3 2 1 0 2 2 2 0 Cytochrome c oxidase assembly protein PET191 CobS_N PF12556.8 ELR16694.1 - 0.18 11.6 0.3 1.9 8.3 0.0 2.6 3 0 0 3 3 3 0 Cobaltochelatase CobS subunit N terminal Pkinase_Tyr PF07714.17 ELR16695.1 - 1.1e-32 113.4 0.0 7.6e-31 107.3 0.0 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ELR16695.1 - 2.6e-22 79.4 0.0 4.6e-22 78.6 0.0 1.3 1 1 0 1 1 1 1 Protein kinase domain Kinase-like PF14531.6 ELR16695.1 - 3.4e-05 23.3 0.0 5.3e-05 22.7 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 ELR16695.1 - 0.035 13.4 0.1 0.063 12.6 0.1 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase PF00069.25 ELR16696.1 - 1.7e-68 230.8 0.1 1.1e-66 224.9 0.1 2.1 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR16696.1 - 1.4e-30 106.5 0.0 3.3e-29 102.0 0.0 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 ELR16696.1 - 3.4e-06 26.6 0.0 5.7e-06 25.8 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 ELR16696.1 - 1.1e-05 24.9 0.0 0.00091 18.6 0.0 2.5 2 1 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 ELR16696.1 - 0.00086 18.2 0.0 0.0014 17.5 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase YrbL-PhoP_reg PF10707.9 ELR16696.1 - 0.064 12.8 0.0 0.12 11.8 0.0 1.4 1 1 0 1 1 1 0 PhoP regulatory network protein YrbL DUF3591 PF12157.8 ELR16697.1 - 2.3e-147 491.3 2.4 1.7e-145 485.1 0.0 3.0 3 0 0 3 3 3 2 Protein of unknown function (DUF3591) Bromodomain PF00439.25 ELR16697.1 - 2.3e-18 66.0 0.2 5.6e-18 64.8 0.2 1.6 1 0 0 1 1 1 1 Bromodomain zf-CCHC_6 PF15288.6 ELR16697.1 - 1.9e-05 24.4 0.4 1.9e-05 24.4 0.4 2.3 2 0 0 2 2 2 1 Zinc knuckle zf-CpG_bind_C PF12269.8 ELR16697.1 - 0.29 10.9 4.4 0.9 9.3 4.4 1.8 1 0 0 1 1 1 0 CpG binding protein zinc finger C terminal domain AAA_11 PF13086.6 ELR16697.1 - 3.7 7.3 6.5 14 5.4 2.2 2.5 2 0 0 2 2 2 0 AAA domain Pkinase_Tyr PF07714.17 ELR16698.1 - 5.6e-59 199.5 0.0 9.6e-59 198.8 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ELR16698.1 - 4.1e-54 183.7 0.0 6.5e-54 183.1 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain SH2 PF00017.24 ELR16698.1 - 3.3e-11 43.1 0.0 7.5e-11 42.0 0.0 1.6 1 0 0 1 1 1 1 SH2 domain SH2_2 PF14633.6 ELR16698.1 - 0.0021 17.5 0.0 0.0069 15.8 0.0 1.8 1 1 0 1 1 1 1 SH2 domain DUF739 PF05339.11 ELR16698.1 - 0.14 12.3 0.0 0.68 10.1 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF739) PIN_12 PF16289.5 ELR16698.1 - 0.94 9.9 6.7 1.2 9.6 0.2 3.1 2 1 1 3 3 3 0 PIN domain APH PF01636.23 ELR16698.1 - 1.7 8.5 3.7 0.68 9.8 0.2 2.1 3 0 0 3 3 3 0 Phosphotransferase enzyme family Macro PF01661.21 ELR16699.1 - 1.3e-36 125.2 0.0 2.3e-36 124.4 0.0 1.4 1 0 0 1 1 1 1 Macro domain SRP-alpha_N PF04086.13 ELR16699.1 - 0.076 12.9 16.3 0.097 12.6 16.3 1.1 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal SAPS PF04499.15 ELR16699.1 - 0.25 10.1 1.1 0.24 10.1 1.1 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Med19 PF10278.9 ELR16699.1 - 0.46 10.4 14.3 0.69 9.8 14.3 1.2 1 0 0 1 1 1 0 Mediator of RNA pol II transcription subunit 19 CDC45 PF02724.14 ELR16699.1 - 1.2 7.4 14.4 1.5 7.0 14.4 1.1 1 0 0 1 1 1 0 CDC45-like protein U79_P34 PF03064.16 ELR16699.1 - 7.4 5.9 11.9 11 5.4 11.9 1.2 1 0 0 1 1 1 0 HSV U79 / HCMV P34 LRR_6 PF13516.6 ELR16700.1 - 0.12 12.5 14.3 0.2 11.8 0.1 6.1 8 0 0 8 8 8 0 Leucine Rich repeat LRR_1 PF00560.33 ELR16700.1 - 0.32 11.7 4.8 4.2 8.3 0.1 5.1 5 0 0 5 5 5 0 Leucine Rich Repeat LRR_4 PF12799.7 ELR16700.1 - 0.63 10.5 21.4 0.53 10.8 0.1 6.4 6 2 2 8 8 8 0 Leucine Rich repeats (2 copies) Ras PF00071.22 ELR16701.1 - 1.2e-35 122.5 0.0 5.1e-35 120.5 0.0 1.8 1 1 0 1 1 1 1 Ras family Roc PF08477.13 ELR16701.1 - 2.9e-23 82.4 0.0 2.9e-22 79.1 0.0 2.1 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR16701.1 - 7e-09 35.4 0.1 1.5e-08 34.3 0.1 1.5 1 1 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 ELR16701.1 - 4.3e-05 23.1 0.0 7.6e-05 22.3 0.0 1.4 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 ELR16701.1 - 0.00012 22.1 0.0 0.00021 21.3 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 ELR16701.1 - 0.0014 18.0 0.0 0.0025 17.2 0.0 1.4 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1_Xtn PF16897.5 ELR16701.1 - 0.008 16.2 0.0 0.013 15.5 0.0 1.4 1 0 0 1 1 1 1 C-terminal region of MMR_HSR1 domain TsaE PF02367.17 ELR16701.1 - 0.04 13.9 0.0 0.075 13.0 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_16 PF13191.6 ELR16701.1 - 0.1 13.0 0.0 0.13 12.7 0.0 1.5 1 1 0 1 1 1 0 AAA ATPase domain AAA_7 PF12775.7 ELR16701.1 - 0.16 11.5 0.0 0.29 10.6 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region Phospholip_A2_1 PF00068.19 ELR16702.1 - 0.095 13.2 3.8 0.094 13.2 2.3 1.7 2 0 0 2 2 2 0 Phospholipase A2 Methyltransf_16 PF10294.9 ELR16703.1 - 7.6e-12 45.3 0.0 4.8e-10 39.5 0.0 2.4 1 1 0 1 1 1 1 Lysine methyltransferase Methyltransf_12 PF08242.12 ELR16703.1 - 0.0059 17.3 0.1 1.1 10.1 0.1 2.7 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 ELR16703.1 - 0.0069 16.2 0.0 0.025 14.4 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 ELR16703.1 - 0.02 14.4 0.3 0.058 12.9 0.3 1.7 1 1 0 1 1 1 0 Methyltransferase small domain Cpn60_TCP1 PF00118.24 ELR16705.1 - 2.7e-153 511.1 17.2 3.1e-153 511.0 17.2 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Ribul_P_3_epim PF00834.19 ELR16705.1 - 0.012 15.0 1.7 0.39 10.1 0.6 2.5 2 0 0 2 2 2 0 Ribulose-phosphate 3 epimerase family DUF892 PF05974.12 ELR16705.1 - 0.023 14.7 2.2 0.95 9.5 0.2 2.6 1 1 1 2 2 2 0 Domain of unknown function (DUF892) LAMTOR5 PF16672.5 ELR16705.1 - 0.084 12.8 0.6 0.38 10.7 0.1 2.3 2 0 0 2 2 2 0 Ragulator complex protein LAMTOR5 DUF356 PF04009.12 ELR16705.1 - 0.12 12.6 0.8 1.2 9.5 0.1 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF356) RNA_pol_L_2 PF13656.6 ELR16706.1 - 2.4e-30 104.1 0.0 3.3e-30 103.7 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain RNA_pol_L PF01193.24 ELR16706.1 - 1e-10 40.9 0.0 1.4e-10 40.5 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain Elongin_A PF06881.11 ELR16707.1 - 1.3e-11 45.0 2.8 2.3e-11 44.2 2.8 1.4 1 1 0 1 1 1 1 RNA polymerase II transcription factor SIII (Elongin) subunit A Ubiquitin_4 PF18036.1 ELR16707.1 - 0.036 14.1 2.6 0.037 14.1 1.7 1.4 1 1 0 1 1 1 0 Ubiquitin-like domain DUF2207 PF09972.9 ELR16707.1 - 2 7.1 6.0 2.5 6.7 6.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) ArfGap PF01412.18 ELR16708.1 - 4.6e-39 133.1 0.1 9.5e-39 132.1 0.1 1.6 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf Ras PF00071.22 ELR16708.1 - 6.1e-30 103.9 0.0 1.2e-29 103.0 0.0 1.5 1 1 0 1 1 1 1 Ras family Roc PF08477.13 ELR16708.1 - 3e-12 46.8 0.0 1.6e-11 44.5 0.0 2.2 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase PH PF00169.29 ELR16708.1 - 3.3e-11 43.6 0.0 6.9e-11 42.6 0.0 1.6 1 0 0 1 1 1 1 PH domain Arf PF00025.21 ELR16708.1 - 2.4e-07 30.4 0.0 4.1e-06 26.4 0.0 2.3 1 1 0 1 1 1 1 ADP-ribosylation factor family Ank_4 PF13637.6 ELR16708.1 - 0.00028 21.4 2.1 0.0043 17.6 0.2 2.3 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 ELR16708.1 - 0.0003 21.3 0.6 0.0006 20.4 0.6 1.5 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) MMR_HSR1 PF01926.23 ELR16708.1 - 0.0026 17.8 0.0 0.0084 16.2 0.0 1.9 1 1 0 1 1 1 1 50S ribosome-binding GTPase Ank_3 PF13606.6 ELR16708.1 - 0.0054 17.1 1.1 0.053 14.1 0.3 2.6 2 0 0 2 2 2 1 Ankyrin repeat Ank PF00023.30 ELR16708.1 - 0.014 15.8 1.2 0.043 14.3 1.2 1.9 1 0 0 1 1 1 0 Ankyrin repeat Ank_5 PF13857.6 ELR16708.1 - 0.04 14.2 0.6 0.094 13.1 0.6 1.6 1 0 0 1 1 1 0 Ankyrin repeats (many copies) PH_13 PF16652.5 ELR16708.1 - 0.1 12.4 0.2 0.4 10.5 0.0 2.0 2 0 0 2 2 2 0 Pleckstrin homology domain Nop14 PF04147.12 ELR16709.1 - 0.55 8.4 3.9 0.6 8.3 3.9 1.0 1 0 0 1 1 1 0 Nop14-like family NOA36 PF06524.12 ELR16709.1 - 2.5 7.3 7.7 3.1 7.1 7.7 1.1 1 0 0 1 1 1 0 NOA36 protein DNA_pol_phi PF04931.13 ELR16709.1 - 7.6 4.5 11.5 8.4 4.4 11.5 1.0 1 0 0 1 1 1 0 DNA polymerase phi Cwf_Cwc_15 PF04889.12 ELR16709.1 - 7.7 6.2 8.1 9.3 5.9 8.1 1.1 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Exo_endo_phos PF03372.23 ELR16710.1 - 1.9e-07 30.8 1.1 7.3e-07 28.9 0.9 2.2 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family TauE PF01925.19 ELR16710.1 - 0.043 13.4 2.9 0.64 9.6 0.1 2.3 2 0 0 2 2 2 0 Sulfite exporter TauE/SafE OAS1_C PF10421.9 ELR16710.1 - 0.15 11.5 0.0 0.28 10.7 0.0 1.3 1 0 0 1 1 1 0 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus VirB8 PF04335.13 ELR16710.1 - 1.4 8.7 3.6 4.9 6.9 0.2 2.5 2 0 0 2 2 2 0 VirB8 protein Prominin PF05478.11 ELR16710.1 - 2.6 5.9 5.5 4.1 5.2 5.5 1.2 1 0 0 1 1 1 0 Prominin GTP_EFTU PF00009.27 ELR16711.1 - 9.7e-51 172.1 0.0 1.6e-50 171.4 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFTUD2 PF16004.5 ELR16711.1 - 1.1e-31 110.0 7.2 1.8e-31 109.3 7.2 1.4 1 0 0 1 1 1 1 116 kDa U5 small nuclear ribonucleoprotein component N-terminus EFG_C PF00679.24 ELR16711.1 - 8.8e-25 86.6 0.0 2e-24 85.5 0.0 1.6 1 0 0 1 1 1 1 Elongation factor G C-terminus EFG_IV PF03764.18 ELR16711.1 - 2.8e-24 85.2 0.0 7.8e-24 83.8 0.0 1.8 1 1 0 1 1 1 1 Elongation factor G, domain IV GTP_EFTU_D2 PF03144.25 ELR16711.1 - 9.4e-11 42.0 0.0 2.5e-10 40.6 0.0 1.8 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 ELR16711.1 - 1.7e-07 31.3 0.0 3.4e-07 30.3 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase EFG_II PF14492.6 ELR16711.1 - 6.3e-06 26.2 0.0 1.6e-05 24.9 0.0 1.6 1 0 0 1 1 1 1 Elongation Factor G, domain II Septin PF00735.18 ELR16711.1 - 0.00016 21.0 0.0 0.00027 20.3 0.0 1.2 1 0 0 1 1 1 1 Septin Roc PF08477.13 ELR16711.1 - 0.0047 17.1 0.0 0.039 14.2 0.0 2.2 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Dynamin_N PF00350.23 ELR16711.1 - 0.054 13.6 0.0 5.3 7.1 0.0 2.3 1 1 1 2 2 2 0 Dynamin family Ras PF00071.22 ELR16711.1 - 0.059 13.0 0.0 0.14 11.7 0.0 1.5 1 1 0 1 1 1 0 Ras family SRPRB PF09439.10 ELR16711.1 - 0.11 11.9 0.1 0.4 10.1 0.1 1.8 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit RsgA_GTPase PF03193.16 ELR16711.1 - 0.11 12.4 0.0 1.7 8.5 0.1 2.3 3 0 0 3 3 3 0 RsgA GTPase Ank_2 PF12796.7 ELR16712.1 - 2.9e-33 114.3 2.2 5e-14 52.6 0.3 3.9 4 0 0 4 4 4 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ELR16712.1 - 1.8e-29 101.7 8.4 9.7e-07 29.2 0.0 6.4 4 1 2 6 6 6 5 Ankyrin repeats (many copies) Ank PF00023.30 ELR16712.1 - 2.3e-28 97.4 5.4 3.3e-06 27.3 0.0 6.4 6 0 0 6 6 6 5 Ankyrin repeat Ank_3 PF13606.6 ELR16712.1 - 4.9e-28 94.1 1.8 1.9e-05 24.7 0.0 6.5 6 0 0 6 6 6 5 Ankyrin repeat Ank_5 PF13857.6 ELR16712.1 - 3.1e-27 94.3 3.9 2.1e-11 43.8 0.5 5.5 4 1 1 5 5 5 4 Ankyrin repeats (many copies) Ras PF00071.22 ELR16712.1 - 1.4e-23 83.3 0.0 2.1e-23 82.7 0.0 1.3 1 0 0 1 1 1 1 Ras family F-box-like PF12937.7 ELR16712.1 - 5.4e-11 42.2 0.6 2.3e-10 40.2 0.0 2.3 2 0 0 2 2 2 1 F-box-like Roc PF08477.13 ELR16712.1 - 3.7e-09 36.8 0.0 8.2e-09 35.7 0.0 1.6 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase F-box PF00646.33 ELR16712.1 - 1e-06 28.4 0.0 2.7e-06 27.1 0.0 1.8 1 0 0 1 1 1 1 F-box domain F-box_5 PF18511.1 ELR16712.1 - 0.00019 20.9 0.0 0.00078 19.0 0.0 2.0 1 0 0 1 1 1 1 F-box F-box_4 PF15966.5 ELR16712.1 - 0.12 12.3 0.7 0.47 10.3 0.1 2.3 1 1 1 2 2 2 0 F-box RabGAP-TBC PF00566.18 ELR16713.1 - 1.7e-46 158.6 4.1 1.7e-45 155.3 0.1 2.9 2 1 0 2 2 2 1 Rab-GTPase-TBC domain Ank_2 PF12796.7 ELR16713.1 - 2.2e-46 156.3 12.5 8.1e-18 64.8 0.8 4.6 2 1 2 4 4 4 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ELR16713.1 - 1.4e-44 149.9 16.6 1.6e-11 44.5 0.1 6.0 1 1 6 7 7 7 7 Ankyrin repeats (many copies) Ank PF00023.30 ELR16713.1 - 4.1e-38 128.2 16.5 1.8e-05 24.9 0.0 7.7 7 0 0 7 7 7 7 Ankyrin repeat Ank_5 PF13857.6 ELR16713.1 - 2.5e-35 120.0 17.7 4.4e-10 39.6 0.0 5.5 1 1 5 6 6 6 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 ELR16713.1 - 1.2e-28 96.0 5.1 0.0035 17.7 0.0 7.7 7 0 0 7 7 7 7 Ankyrin repeat Med19 PF10278.9 ELR16713.1 - 0.58 10.1 11.5 1.2 9.0 11.5 1.4 1 0 0 1 1 1 0 Mediator of RNA pol II transcription subunit 19 Dicty_REP PF05086.12 ELR16713.1 - 0.62 8.0 3.1 0.88 7.5 3.1 1.2 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Presenilin PF01080.17 ELR16713.1 - 7.6 5.2 8.6 14 4.4 8.6 1.3 1 0 0 1 1 1 0 Presenilin NST1 PF13945.6 ELR16713.1 - 8.7 6.4 17.7 0.76 9.9 0.9 2.5 1 1 1 2 2 2 0 Salt tolerance down-regulator Pkinase PF00069.25 ELR16715.1 - 0.0016 17.8 0.0 0.0024 17.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain SR-25 PF10500.9 ELR16715.1 - 0.073 12.7 6.5 0.12 12.0 6.5 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein DUF4692 PF15763.5 ELR16715.1 - 1.5 9.2 4.2 2.9 8.4 4.2 1.3 1 0 0 1 1 1 0 Regulator of human erythroid cell expansion (RHEX) Metal_resist PF13801.6 ELR16716.1 - 0.0011 19.2 0.4 0.0019 18.4 0.4 1.4 1 0 0 1 1 1 1 Heavy-metal resistance Methyltransf_16 PF10294.9 ELR16718.1 - 3.8e-12 46.3 0.0 6.7e-07 29.2 0.0 2.2 2 0 0 2 2 2 2 Lysine methyltransferase Methyltransf_23 PF13489.6 ELR16718.1 - 1.7e-07 31.2 0.0 2.3e-07 30.8 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ELR16718.1 - 3.1e-06 27.8 0.1 1.6e-05 25.6 0.1 2.0 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 ELR16718.1 - 0.0003 20.4 0.0 0.00046 19.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_25 PF13649.6 ELR16718.1 - 0.0012 19.5 0.2 0.0086 16.8 0.0 2.3 1 1 0 2 2 2 1 Methyltransferase domain PrmA PF06325.13 ELR16718.1 - 0.015 14.7 0.0 0.02 14.3 0.0 1.1 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_11 PF08241.12 ELR16718.1 - 0.016 15.8 0.1 0.27 11.9 0.0 2.3 2 0 0 2 2 2 0 Methyltransferase domain PCMT PF01135.19 ELR16718.1 - 0.17 11.6 0.0 0.26 11.0 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Ras PF00071.22 ELR16719.1 - 2.6e-51 173.4 0.0 3.7e-51 172.9 0.0 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR16719.1 - 3.9e-29 101.3 0.0 8.3e-29 100.2 0.0 1.6 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ank_5 PF13857.6 ELR16719.1 - 1.2e-19 70.1 1.9 9.2e-11 41.8 0.0 3.7 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 ELR16719.1 - 8.8e-18 64.7 0.1 5.4e-14 52.5 0.0 2.8 3 0 0 3 3 3 2 Ankyrin repeats (3 copies) Ank PF00023.30 ELR16719.1 - 1.9e-17 62.9 1.1 1.6e-06 28.3 0.0 4.4 4 0 0 4 4 4 3 Ankyrin repeat Ank_3 PF13606.6 ELR16719.1 - 2.3e-16 58.2 1.9 0.00023 21.4 0.0 4.7 5 0 0 5 5 4 3 Ankyrin repeat Ank_4 PF13637.6 ELR16719.1 - 8.4e-16 58.1 0.1 3.1e-05 24.4 0.0 3.6 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Arf PF00025.21 ELR16719.1 - 6.9e-11 41.9 0.0 1e-10 41.3 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family F-box-like PF12937.7 ELR16719.1 - 3.7e-06 26.7 0.1 7e-06 25.8 0.1 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ELR16719.1 - 1.9e-05 24.4 0.3 3.5e-05 23.6 0.3 1.4 1 0 0 1 1 1 1 F-box domain F-box_4 PF15966.5 ELR16719.1 - 4.1e-05 23.4 0.1 9.1e-05 22.3 0.1 1.6 1 0 0 1 1 1 1 F-box Gtr1_RagA PF04670.12 ELR16719.1 - 0.027 13.8 0.0 0.038 13.3 0.0 1.2 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region SRPRB PF09439.10 ELR16719.1 - 0.044 13.2 0.0 0.081 12.4 0.0 1.3 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 ELR16719.1 - 0.047 13.8 0.0 0.088 12.9 0.0 1.5 1 0 0 1 1 1 0 50S ribosome-binding GTPase NB-ARC PF00931.22 ELR16719.1 - 0.075 12.2 0.0 0.14 11.3 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain PduV-EutP PF10662.9 ELR16719.1 - 0.2 11.4 0.0 0.38 10.5 0.0 1.4 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation ABC1 PF03109.16 ELR16720.1 - 6.4e-16 58.6 0.0 1.1e-15 57.8 0.0 1.4 1 0 0 1 1 1 1 ABC1 family DUF4397 PF14344.6 ELR16722.1 - 5e-22 78.9 0.4 1.7e-13 51.4 0.3 2.1 1 1 1 2 2 2 2 Domain of unknown function (DUF4397) RabGAP-TBC PF00566.18 ELR16724.1 - 8.6e-48 162.8 7.1 1.1e-47 162.5 7.1 1.1 1 0 0 1 1 1 1 Rab-GTPase-TBC domain KTI12 PF08433.10 ELR16725.1 - 1.4e-65 221.5 0.0 1.7e-65 221.2 0.0 1.0 1 0 0 1 1 1 1 Chromatin associated protein KTI12 AAA_33 PF13671.6 ELR16725.1 - 0.00033 20.8 0.0 0.0011 19.1 0.0 1.8 2 0 0 2 2 2 1 AAA domain CaMBD PF02888.16 ELR16725.1 - 0.14 12.4 0.1 0.31 11.3 0.1 1.6 1 0 0 1 1 1 0 Calmodulin binding domain DUF4536 PF15055.6 ELR16725.1 - 0.15 12.3 0.2 0.44 10.8 0.2 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF4536) Rho_N PF07498.12 ELR16725.1 - 0.58 10.1 2.0 0.89 9.5 0.4 2.1 2 0 0 2 2 2 0 Rho termination factor, N-terminal domain Acid_PPase PF12689.7 ELR16726.1 - 3e-40 137.8 0.0 4.5e-40 137.3 0.0 1.2 1 0 0 1 1 1 1 Acid Phosphatase WD40 PF00400.32 ELR16727.1 - 5.3e-13 49.2 16.9 0.0095 16.8 1.2 5.4 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ELR16727.1 - 5e-08 33.1 0.0 0.018 15.3 0.1 3.7 3 1 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain IKI3 PF04762.12 ELR16727.1 - 0.086 10.8 0.0 0.21 9.5 0.1 1.5 2 0 0 2 2 2 0 IKI3 family Pkinase PF00069.25 ELR16728.1 - 1.4e-45 155.7 0.0 2.3e-45 155.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR16728.1 - 3.7e-36 124.8 0.0 5.9e-36 124.1 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 ELR16728.1 - 0.00037 19.4 0.2 0.0011 17.8 0.0 1.7 2 0 0 2 2 2 1 Fungal protein kinase Haspin_kinase PF12330.8 ELR16728.1 - 0.0017 17.4 2.2 0.41 9.5 0.4 2.1 2 0 0 2 2 2 2 Haspin like kinase domain APH PF01636.23 ELR16728.1 - 0.0034 17.3 0.0 3 7.7 0.0 2.2 1 1 1 2 2 2 2 Phosphotransferase enzyme family PBD PF00786.28 ELR16728.1 - 0.018 15.4 0.0 0.053 13.9 0.0 1.8 1 0 0 1 1 1 0 P21-Rho-binding domain N_formyltrans_C PF18216.1 ELR16728.1 - 0.037 13.7 0.0 0.29 10.8 0.0 2.2 2 0 0 2 2 2 0 N-formyltransferase dimerization C-terminal domain SET PF00856.28 ELR16729.1 - 8.3 6.8 14.0 0.17 12.3 2.4 2.4 1 1 1 2 2 2 0 SET domain DUF1838 PF08894.11 ELR16730.1 - 1.9e-65 220.9 0.1 2.3e-65 220.6 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1838) CENP-Q PF13094.6 ELR16731.1 - 0.016 15.4 1.1 0.025 14.8 1.1 1.2 1 0 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit DUF4795 PF16043.5 ELR16731.1 - 0.027 14.1 1.6 0.045 13.3 1.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4795) Laminin_II PF06009.12 ELR16731.1 - 0.044 13.8 1.0 0.071 13.1 1.0 1.2 1 0 0 1 1 1 0 Laminin Domain II Mre11_DNA_bind PF04152.14 ELR16731.1 - 0.046 14.0 1.3 0.079 13.3 1.3 1.3 1 0 0 1 1 1 0 Mre11 DNA-binding presumed domain CENP-H PF05837.12 ELR16731.1 - 0.057 13.8 0.4 0.057 13.8 0.4 1.5 2 0 0 2 2 2 0 Centromere protein H (CENP-H) TIM21 PF08294.11 ELR16731.1 - 0.13 12.2 0.0 0.27 11.1 0.0 1.5 1 0 0 1 1 1 0 TIM21 Rsm22 PF09243.10 ELR16732.1 - 0.15 11.4 0.0 0.17 11.1 0.0 1.1 1 0 0 1 1 1 0 Mitochondrial small ribosomal subunit Rsm22 Nro1 PF12753.7 ELR16733.1 - 0.0043 16.1 0.3 0.0047 15.9 0.3 1.0 1 0 0 1 1 1 1 Nuclear pore complex subunit Nro1 PH PF00169.29 ELR16733.1 - 0.052 14.1 0.1 0.067 13.7 0.1 1.2 1 0 0 1 1 1 0 PH domain DtxR PF18357.1 ELR16734.1 - 0.25 11.1 0.4 23 4.8 0.1 2.5 2 0 0 2 2 2 0 Diphteria toxin repressor SH3 domain Peptidase_S8 PF00082.22 ELR16735.1 - 7.3e-05 22.2 0.1 0.0015 17.9 0.1 2.1 1 1 0 1 1 1 1 Subtilase family PINIT PF14324.6 ELR16737.1 - 0.058 13.7 0.2 0.11 12.8 0.0 1.5 2 0 0 2 2 2 0 PINIT domain PIF1 PF05970.14 ELR16738.1 - 2.4e-20 73.0 0.0 3.2e-20 72.6 0.0 1.1 1 0 0 1 1 1 1 PIF1-like helicase AAA_30 PF13604.6 ELR16738.1 - 3.4e-14 53.0 0.2 4.9e-14 52.5 0.2 1.2 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 ELR16738.1 - 5.8e-06 26.7 0.2 7.5e-05 23.1 0.1 2.4 1 1 0 2 2 2 1 AAA domain DUF2075 PF09848.9 ELR16738.1 - 0.00029 20.2 0.0 0.00056 19.3 0.0 1.6 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) AAA_16 PF13191.6 ELR16738.1 - 0.00047 20.6 0.0 0.00077 19.9 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 ELR16738.1 - 0.00054 20.2 0.2 0.0024 18.1 0.2 2.0 1 1 0 1 1 1 1 AAA domain T2SSE PF00437.20 ELR16738.1 - 0.0039 16.3 0.0 0.011 14.8 0.0 1.7 2 0 0 2 2 2 1 Type II/IV secretion system protein AAA_7 PF12775.7 ELR16738.1 - 0.0069 15.9 0.0 0.012 15.1 0.0 1.3 1 0 0 1 1 1 1 P-loop containing dynein motor region Herpes_Helicase PF02689.14 ELR16738.1 - 0.0072 14.3 0.0 1.1 7.2 0.0 2.1 2 0 0 2 2 2 2 Helicase AAA PF00004.29 ELR16738.1 - 0.012 16.0 0.0 0.025 15.0 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) RsgA_GTPase PF03193.16 ELR16738.1 - 0.022 14.7 0.1 0.035 14.0 0.1 1.2 1 0 0 1 1 1 0 RsgA GTPase NACHT PF05729.12 ELR16738.1 - 0.041 13.8 0.1 0.085 12.8 0.1 1.5 1 0 0 1 1 1 0 NACHT domain AAA_29 PF13555.6 ELR16738.1 - 0.062 13.1 0.0 0.11 12.2 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain DUF815 PF05673.13 ELR16738.1 - 0.074 12.2 0.1 0.12 11.5 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF815) NTPase_1 PF03266.15 ELR16738.1 - 0.078 12.9 0.2 0.78 9.6 0.1 2.1 2 0 0 2 2 2 0 NTPase AAA_5 PF07728.14 ELR16738.1 - 0.13 12.3 0.1 0.44 10.5 0.1 1.8 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) Sigma54_activat PF00158.26 ELR16738.1 - 0.16 11.6 0.4 0.31 10.7 0.1 1.6 2 0 0 2 2 2 0 Sigma-54 interaction domain DUF853 PF05872.12 ELR16738.1 - 0.42 9.1 2.9 0.19 10.3 0.5 1.6 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF853) DUF1479 PF07350.12 ELR16740.1 - 0.048 12.4 0.0 0.061 12.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1479) Inhibitor_I29 PF08246.12 ELR16743.1 - 8.4e-09 35.7 8.6 1.8e-08 34.7 8.4 1.7 1 1 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) TFIIA PF03153.13 ELR16744.1 - 0.071 13.1 9.6 0.075 13.0 9.6 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Dicty_REP PF05086.12 ELR16744.1 - 0.14 10.1 8.8 0.18 9.8 8.8 1.2 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Nop14 PF04147.12 ELR16744.1 - 0.17 10.1 13.6 0.16 10.1 13.6 1.1 1 0 0 1 1 1 0 Nop14-like family CDC45 PF02724.14 ELR16744.1 - 0.73 8.1 10.3 0.72 8.1 10.3 1.2 1 0 0 1 1 1 0 CDC45-like protein NOA36 PF06524.12 ELR16744.1 - 8.8 5.5 21.0 3.9 6.7 19.0 1.4 2 0 0 2 2 2 0 NOA36 protein Myb_DNA-binding PF00249.31 ELR16745.1 - 3.8e-12 46.2 0.0 8.3e-12 45.1 0.0 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain ZZ PF00569.17 ELR16745.1 - 6.2e-10 38.7 7.3 1.1e-09 37.9 7.3 1.5 1 0 0 1 1 1 1 Zinc finger, ZZ type SWIRM PF04433.17 ELR16745.1 - 6.8e-06 26.3 0.0 2.5e-05 24.6 0.0 2.0 1 0 0 1 1 1 1 SWIRM domain Myb_DNA-bind_6 PF13921.6 ELR16745.1 - 3.6e-05 23.9 0.0 0.00013 22.2 0.0 2.0 1 0 0 1 1 1 1 Myb-like DNA-binding domain C1_2 PF03107.16 ELR16745.1 - 0.053 13.9 5.4 0.098 13.0 5.4 1.4 1 0 0 1 1 1 0 C1 domain DUF2625 PF10946.8 ELR16746.1 - 0.037 13.1 0.0 0.053 12.6 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function DUF2625 Sial-lect-inser PF09264.10 ELR16746.1 - 0.12 12.1 0.0 0.18 11.5 0.0 1.2 1 0 0 1 1 1 0 Vibrio cholerae sialidase, lectin insertion Frizzled PF01534.17 ELR16747.1 - 4.7e-21 75.2 16.6 4.7e-21 75.2 16.6 1.4 2 0 0 2 2 2 1 Frizzled/Smoothened family membrane region Dicty_CAR PF05462.11 ELR16747.1 - 3.8e-08 32.8 11.3 7.4e-08 31.9 11.3 1.4 1 0 0 1 1 1 1 Slime mold cyclic AMP receptor Fz PF01392.22 ELR16747.1 - 3e-06 27.8 0.6 5.7e-06 26.9 0.6 1.4 1 0 0 1 1 1 1 Fz domain DCX PF03607.17 ELR16748.1 - 1.6e-10 40.9 0.0 2.5e-10 40.3 0.0 1.2 1 0 0 1 1 1 1 Doublecortin KHA PF11834.8 ELR16748.1 - 0.00034 20.6 0.1 0.00059 19.9 0.0 1.4 2 0 0 2 2 2 1 KHA, dimerisation domain of potassium ion channel Fringe PF02434.16 ELR16748.1 - 0.062 12.7 0.0 0.11 12.0 0.0 1.3 1 0 0 1 1 1 0 Fringe-like YfcL PF08891.11 ELR16749.1 - 0.14 12.6 1.8 0.27 11.6 1.8 1.5 1 0 0 1 1 1 0 YfcL protein APG12 PF04110.13 ELR16750.1 - 4.5e-25 87.9 0.0 5.4e-25 87.6 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-like autophagy protein Apg12 Atg8 PF02991.16 ELR16750.1 - 0.0023 18.1 0.0 0.0026 17.9 0.0 1.1 1 0 0 1 1 1 1 Autophagy protein Atg8 ubiquitin like P3A PF08727.11 ELR16750.1 - 0.15 11.4 0.0 0.29 10.6 0.0 1.4 1 0 0 1 1 1 0 Poliovirus 3A protein like Pmp3 PF01679.17 ELR16751.1 - 4.7e-18 65.1 12.3 5.5e-18 64.9 12.3 1.1 1 0 0 1 1 1 1 Proteolipid membrane potential modulator DUF872 PF05915.12 ELR16751.1 - 0.29 11.3 2.2 0.34 11.1 2.2 1.1 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF872) F-box-like PF12937.7 ELR16752.1 - 1.1e-10 41.2 0.7 2.4e-10 40.1 0.7 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ELR16752.1 - 8.6e-07 28.7 1.0 1.9e-06 27.6 0.4 1.9 2 0 0 2 2 2 1 F-box domain Raftlin PF15250.6 ELR16753.1 - 4.8 5.8 13.0 5.7 5.6 13.0 1.2 1 0 0 1 1 1 0 Raftlin DUF2151 PF10221.9 ELR16753.1 - 5.7 5.4 20.2 7.1 5.1 20.2 1.1 1 0 0 1 1 1 0 Cell cycle and development regulator bZIP_1 PF00170.21 ELR16754.1 - 0.0015 18.5 0.4 0.0028 17.7 0.4 1.4 1 0 0 1 1 1 1 bZIP transcription factor TACC_C PF05010.14 ELR16754.1 - 0.033 14.0 0.6 0.033 14.0 0.6 1.3 2 0 0 2 2 2 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal Ras PF00071.22 ELR16755.1 - 6.5e-46 155.9 0.0 6.2e-31 107.2 0.0 2.0 2 0 0 2 2 2 2 Ras family Roc PF08477.13 ELR16755.1 - 7.8e-17 61.6 0.0 1.3e-08 35.1 0.0 2.2 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR16755.1 - 9.3e-05 21.9 0.0 0.41 10.1 0.0 2.1 2 0 0 2 2 2 2 ADP-ribosylation factor family AAA_16 PF13191.6 ELR16755.1 - 0.019 15.4 0.0 0.04 14.3 0.0 1.5 1 1 0 1 1 1 0 AAA ATPase domain AAA_7 PF12775.7 ELR16755.1 - 0.097 12.2 0.0 0.14 11.7 0.0 1.2 1 0 0 1 1 1 0 P-loop containing dynein motor region Syntaxin-6_N PF09177.11 ELR16756.1 - 3.9e-17 62.6 13.0 5.5e-12 46.1 0.1 3.8 2 2 1 3 3 3 2 Syntaxin 6, N-terminal Mei5 PF10376.9 ELR16756.1 - 0.088 12.7 6.5 0.12 12.3 6.5 1.3 1 1 0 1 1 1 0 Double-strand recombination repair protein CorA PF01544.18 ELR16756.1 - 0.1 11.9 3.6 0.15 11.3 3.6 1.2 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein COG2 PF06148.11 ELR16756.1 - 0.5 10.5 7.5 6.3 6.9 0.5 2.8 1 1 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 DUF5446 PF17522.2 ELR16756.1 - 1.5 9.1 5.7 5.2 7.3 4.4 2.5 1 1 2 3 3 3 0 Family of unknown function (DUF5446) DUF1664 PF07889.12 ELR16756.1 - 1.8 8.6 5.6 1.8 8.6 2.6 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Aminotran_1_2 PF00155.21 ELR16757.1 - 2.7e-30 105.8 0.0 2.1e-29 102.8 0.0 1.9 1 1 0 1 1 1 1 Aminotransferase class I and II Aminotran_MocR PF12897.7 ELR16757.1 - 0.00014 20.8 0.0 0.00021 20.2 0.0 1.3 1 0 0 1 1 1 1 Alanine-glyoxylate amino-transferase CBS PF00571.28 ELR16758.1 - 1.2e-27 96.1 2.9 4.2e-11 43.1 0.1 4.3 4 0 0 4 4 4 4 CBS domain HATPase_c PF02518.26 ELR16759.1 - 1.2e-22 80.6 0.0 2.4e-22 79.5 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 ELR16759.1 - 3.1e-17 62.3 0.0 9.5e-17 60.8 0.0 1.9 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain Response_reg PF00072.24 ELR16759.1 - 6.4e-16 58.5 0.3 1.7e-15 57.2 0.3 1.7 1 0 0 1 1 1 1 Response regulator receiver domain Aminotran_1_2 PF00155.21 ELR16760.1 - 1.3e-63 215.4 0.0 1.5e-63 215.1 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.21 ELR16760.1 - 1.3e-07 31.2 0.0 2e-07 30.6 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase Cys_Met_Meta_PP PF01053.20 ELR16760.1 - 6.7e-07 28.2 0.0 1.3e-06 27.2 0.0 1.4 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_5 PF00266.19 ELR16760.1 - 6.3e-06 25.4 0.0 3.4e-05 23.0 0.0 1.9 2 0 0 2 2 2 1 Aminotransferase class-V DegT_DnrJ_EryC1 PF01041.17 ELR16760.1 - 3.8e-05 23.2 0.0 9.4e-05 21.9 0.0 1.6 2 0 0 2 2 2 1 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_MocR PF12897.7 ELR16760.1 - 0.051 12.4 0.0 0.15 10.8 0.0 1.7 2 0 0 2 2 2 0 Alanine-glyoxylate amino-transferase OKR_DC_1 PF01276.20 ELR16760.1 - 0.21 10.2 0.0 0.35 9.6 0.0 1.3 1 0 0 1 1 1 0 Orn/Lys/Arg decarboxylase, major domain FRQ PF09421.10 ELR16762.1 - 0.13 10.2 0.1 0.2 9.7 0.1 1.2 1 0 0 1 1 1 0 Frequency clock protein DNA_pol_phi PF04931.13 ELR16762.1 - 6.7 4.7 7.9 9.4 4.2 7.9 1.1 1 0 0 1 1 1 0 DNA polymerase phi MPC PF03650.13 ELR16763.1 - 1e-12 48.1 0.4 1.3e-12 47.8 0.4 1.1 1 0 0 1 1 1 1 Mitochondrial pyruvate carriers MPC PF03650.13 ELR16764.1 - 1.1e-11 44.9 0.0 1.2e-11 44.7 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial pyruvate carriers MtN3_slv PF03083.16 ELR16764.1 - 0.014 15.4 0.1 0.02 14.9 0.1 1.3 1 0 0 1 1 1 0 Sugar efflux transporter for intercellular exchange RVT_2 PF07727.14 ELR16765.1 - 3.3e-25 89.1 0.1 3.5e-25 89.1 0.1 1.0 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RFX_DNA_binding PF02257.15 ELR16766.1 - 6.5e-20 71.5 0.0 2.1e-19 69.9 0.0 1.9 1 0 0 1 1 1 1 RFX DNA-binding domain F-box PF00646.33 ELR16767.1 - 3.1e-05 23.7 0.6 5.4e-05 23.0 0.6 1.4 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 ELR16767.1 - 8.4e-05 22.4 2.4 0.00015 21.6 2.4 1.4 1 0 0 1 1 1 1 F-box-like FAM60A PF15396.6 ELR16767.1 - 0.033 14.2 2.6 0.045 13.8 2.6 1.0 1 0 0 1 1 1 0 Protein Family FAM60A Glyco_hydro_31 PF01055.26 ELR16768.1 - 8.6e-141 470.1 0.6 7e-140 467.1 0.6 2.0 1 1 0 1 1 1 1 Glycosyl hydrolases family 31 NtCtMGAM_N PF16863.5 ELR16768.1 - 1.8e-29 102.2 0.1 3.6e-29 101.3 0.1 1.5 1 0 0 1 1 1 1 N-terminal barrel of NtMGAM and CtMGAM, maltase-glucoamylase Gal_mutarotas_2 PF13802.6 ELR16768.1 - 2.2e-10 40.7 0.3 2.2e-10 40.7 0.3 2.6 3 0 0 3 3 3 1 Galactose mutarotase-like Trefoil PF00088.18 ELR16768.1 - 7.8e-07 28.9 3.8 7.8e-07 28.9 3.8 1.9 2 0 0 2 2 2 1 Trefoil (P-type) domain DUF5110 PF17137.4 ELR16768.1 - 0.12 12.7 0.0 0.29 11.4 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF5110) WD40 PF00400.32 ELR16769.1 - 2.1e-39 132.8 26.3 3.8e-07 30.7 0.6 7.3 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ELR16769.1 - 2.7e-18 66.0 6.8 0.0014 18.9 0.1 5.3 2 1 2 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain VID27 PF08553.10 ELR16769.1 - 0.018 14.1 0.0 4.5 6.2 0.0 2.1 2 0 0 2 2 2 0 VID27 C-terminal WD40-like domain WD40_like PF17005.5 ELR16769.1 - 0.031 13.6 0.0 2.5 7.3 0.0 2.4 1 1 0 2 2 2 0 WD40-like domain Glyco_hydro_10 PF00331.20 ELR16770.1 - 3.8e-31 108.4 0.0 5.5e-31 107.9 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 10 Wzt_C PF14524.6 ELR16770.1 - 5e-06 26.6 0.0 0.084 12.9 0.0 3.9 3 1 1 4 4 4 2 Wzt C-terminal domain NPCBM_assoc PF10633.9 ELR16770.1 - 0.00077 19.7 36.6 0.025 14.8 0.6 6.3 5 2 1 6 6 6 3 NPCBM-associated, NEW3 domain of alpha-galactosidase DUF4625 PF15418.6 ELR16770.1 - 0.0021 18.3 0.0 0.66 10.2 0.0 3.3 4 0 0 4 4 4 1 Domain of unknown function (DUF4625) E1_DerP2_DerF2 PF02221.15 ELR16770.1 - 0.013 15.9 0.0 4.9 7.6 0.0 3.1 2 1 0 2 2 2 0 ML domain Fn3-like PF14310.6 ELR16770.1 - 0.022 14.9 0.1 13 5.9 0.0 4.3 4 0 0 4 4 4 0 Fibronectin type III-like domain MG2 PF01835.19 ELR16770.1 - 0.063 13.7 7.9 1.6 9.2 0.1 4.6 5 1 0 5 5 5 0 MG2 domain CARDB PF07705.11 ELR16770.1 - 0.3 11.4 15.1 0.46 10.8 0.5 4.2 3 0 0 3 3 3 0 CARDB SPG48 PF14764.6 ELR16771.1 - 1e-32 113.1 1.5 1e-32 113.1 1.5 2.0 2 0 0 2 2 2 1 AP-5 complex subunit, vesicle trafficking Mo25 PF08569.11 ELR16771.1 - 0.04 13.3 0.6 0.074 12.4 0.6 1.4 1 0 0 1 1 1 0 Mo25-like BSP_II PF05432.11 ELR16772.1 - 0.0013 18.5 11.9 0.16 11.6 1.4 2.4 2 0 0 2 2 2 2 Bone sialoprotein II (BSP-II) PBP1_TM PF14812.6 ELR16772.1 - 0.017 15.5 14.6 0.66 10.4 2.5 2.6 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DUF4611 PF15387.6 ELR16772.1 - 0.026 14.7 12.0 0.34 11.2 2.1 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4611) MPP6 PF10175.9 ELR16772.1 - 0.05 14.1 1.0 0.05 14.1 1.0 2.5 2 0 0 2 2 2 0 M-phase phosphoprotein 6 RNA_pol_3_Rpc31 PF11705.8 ELR16772.1 - 0.066 13.5 13.8 0.55 10.5 4.3 2.5 2 0 0 2 2 2 0 DNA-directed RNA polymerase III subunit Rpc31 FAM176 PF14851.6 ELR16772.1 - 0.15 11.7 15.2 0.99 9.1 3.6 2.6 2 0 0 2 2 2 0 FAM176 family GOLD_2 PF13897.6 ELR16772.1 - 0.21 12.1 7.1 2.8 8.4 0.6 2.5 2 0 0 2 2 2 0 Golgi-dynamics membrane-trafficking Radial_spoke PF04712.12 ELR16772.1 - 0.4 9.6 11.8 0.23 10.4 1.3 2.3 2 0 0 2 2 2 0 Radial spokehead-like protein RXT2_N PF08595.11 ELR16772.1 - 0.44 10.6 9.3 4.1 7.4 0.6 2.4 2 0 0 2 2 2 0 RXT2-like, N-terminal DUF1770 PF08589.10 ELR16772.1 - 0.71 10.9 7.5 3.2 8.8 0.5 2.7 2 0 0 2 2 2 0 Fungal protein of unknown function (DUF1770) Astro_capsid_p PF12226.8 ELR16772.1 - 0.76 8.9 11.4 0.51 9.4 2.4 2.2 2 0 0 2 2 2 0 Turkey astrovirus capsid protein PI3K_1B_p101 PF10486.9 ELR16772.1 - 0.76 7.5 7.6 0.13 10.1 0.2 2.0 2 0 0 2 2 2 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit PIG-S PF10510.9 ELR16772.1 - 1.3 7.8 5.5 2.5 6.8 0.6 2.2 2 0 0 2 2 2 0 Phosphatidylinositol-glycan biosynthesis class S protein DUF4820 PF16091.5 ELR16772.1 - 1.5 8.1 8.2 6.1 6.1 1.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4820) DUF2052 PF09747.9 ELR16772.1 - 2.9 8.0 22.7 0.51 10.4 2.7 2.8 3 0 0 3 3 3 0 Coiled-coil domain containing protein (DUF2052) CENP-B_dimeris PF09026.10 ELR16772.1 - 3 8.3 20.0 9.8 6.6 3.1 2.6 2 0 0 2 2 2 0 Centromere protein B dimerisation domain DUF4746 PF15928.5 ELR16772.1 - 5.9 6.2 13.7 6 6.2 2.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4746) Myc_N PF01056.18 ELR16772.1 - 9.5 6.0 25.4 0.46 10.3 5.9 2.2 1 1 1 2 2 2 0 Myc amino-terminal region INTS2 PF14750.6 ELR16773.1 - 9.6e-30 102.9 0.5 1.1e-29 102.7 0.5 1.0 1 0 0 1 1 1 1 Integrator complex subunit 2 INTS2 PF14750.6 ELR16774.1 - 1.9e-133 446.3 9.6 4.2e-129 431.9 5.2 2.5 1 1 1 2 2 2 2 Integrator complex subunit 2 zf-MYND PF01753.18 ELR16775.1 - 1.7e-06 28.0 5.5 1.7e-06 28.0 5.5 2.3 2 0 0 2 2 2 1 MYND finger RAMA PF18755.1 ELR16775.1 - 0.00074 19.9 0.0 0.0084 16.5 0.0 2.9 2 0 0 2 2 2 1 Restriction Enzyme Adenine Methylase Associated SET PF00856.28 ELR16775.1 - 0.0014 19.0 3.2 0.0014 19.0 3.2 5.2 2 2 0 2 2 2 1 SET domain zf-C6H2 PF15801.5 ELR16775.1 - 0.025 14.9 4.4 0.075 13.3 4.4 1.9 1 0 0 1 1 1 0 zf-MYND-like zinc finger, mRNA-binding YL1 PF05764.13 ELR16775.1 - 4.6 7.3 79.6 0.42 10.7 13.5 5.1 5 0 0 5 5 5 0 YL1 nuclear protein Skp1_POZ PF03931.15 ELR16776.1 - 1.8e-22 79.3 0.2 3e-22 78.6 0.2 1.4 1 0 0 1 1 1 1 Skp1 family, tetramerisation domain Skp1 PF01466.19 ELR16776.1 - 5.9e-12 45.5 0.0 9.9e-12 44.8 0.0 1.4 1 0 0 1 1 1 1 Skp1 family, dimerisation domain BTB PF00651.31 ELR16776.1 - 0.1 12.8 0.2 0.65 10.3 0.2 2.0 1 1 0 1 1 1 0 BTB/POZ domain MRP-S32 PF10210.9 ELR16777.1 - 0.017 15.6 0.1 1 9.9 0.0 2.4 2 1 1 3 3 3 0 Mitochondrial 28S ribosomal protein S32 LBP_BPI_CETP_C PF02886.17 ELR16778.1 - 3.5e-36 124.9 0.0 5.6e-36 124.2 0.0 1.3 1 0 0 1 1 1 1 LBP / BPI / CETP family, C-terminal domain LBP_BPI_CETP PF01273.25 ELR16778.1 - 1.1e-17 64.2 0.0 1.9e-17 63.4 0.0 1.3 1 0 0 1 1 1 1 LBP / BPI / CETP family, N-terminal domain Actin PF00022.19 ELR16779.1 - 8.4e-47 159.7 0.2 1.7e-26 92.8 0.1 3.0 3 0 0 3 3 3 3 Actin VIT PF08487.10 ELR16781.1 - 1.2e-37 128.5 0.9 3.2e-37 127.1 0.9 1.8 1 0 0 1 1 1 1 Vault protein inter-alpha-trypsin domain VWA_3 PF13768.6 ELR16781.1 - 1.2e-32 113.0 0.0 2.5e-32 112.0 0.0 1.6 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.28 ELR16781.1 - 4e-15 56.5 0.1 1.1e-14 55.1 0.1 1.8 2 0 0 2 2 2 1 von Willebrand factor type A domain VIT_2 PF13757.6 ELR16781.1 - 2.4e-14 53.0 1.0 3.9e-14 52.3 0.1 1.8 2 0 0 2 2 2 1 Vault protein inter-alpha-trypsin domain VWA_2 PF13519.6 ELR16781.1 - 6.9e-11 42.7 0.0 2.3e-10 41.1 0.0 1.9 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_CoxE PF05762.14 ELR16781.1 - 0.023 14.1 0.0 0.05 13.0 0.0 1.5 1 0 0 1 1 1 0 VWA domain containing CoxE-like protein Serpin PF00079.20 ELR16782.1 - 1e-86 291.6 2.6 6.9e-78 262.5 0.3 2.0 1 1 1 2 2 2 2 Serpin (serine protease inhibitor) LBP_BPI_CETP_C PF02886.17 ELR16783.1 - 8.6e-36 123.6 0.0 1.4e-35 122.9 0.0 1.4 1 0 0 1 1 1 1 LBP / BPI / CETP family, C-terminal domain LBP_BPI_CETP PF01273.25 ELR16783.1 - 6.7e-20 71.3 0.1 1.7e-19 70.0 0.0 1.6 2 0 0 2 2 2 1 LBP / BPI / CETP family, N-terminal domain VIT PF08487.10 ELR16784.1 - 1e-36 125.5 0.8 1e-36 125.5 0.8 2.6 2 0 0 2 2 2 1 Vault protein inter-alpha-trypsin domain VWA_3 PF13768.6 ELR16784.1 - 1.3e-32 112.8 0.0 2.7e-32 111.9 0.0 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.28 ELR16784.1 - 5.2e-15 56.1 0.1 1.2e-14 55.0 0.1 1.6 1 0 0 1 1 1 1 von Willebrand factor type A domain VIT_2 PF13757.6 ELR16784.1 - 1.8e-13 50.1 0.1 3.9e-13 49.1 0.1 1.5 1 0 0 1 1 1 1 Vault protein inter-alpha-trypsin domain VWA_2 PF13519.6 ELR16784.1 - 8.2e-11 42.5 0.0 2.4e-10 41.0 0.0 1.9 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_CoxE PF05762.14 ELR16784.1 - 0.025 14.0 0.0 0.053 12.9 0.0 1.4 1 0 0 1 1 1 0 VWA domain containing CoxE-like protein TIMELESS_C PF05029.13 ELR16784.1 - 0.19 10.9 8.1 0.34 10.0 8.1 1.3 1 0 0 1 1 1 0 Timeless protein C terminal region Actin PF00022.19 ELR16785.1 - 7e-08 31.5 0.3 1.5e-07 30.4 0.0 1.6 2 0 0 2 2 2 1 Actin TIMELESS_C PF05029.13 ELR16785.1 - 0.0044 16.2 4.1 0.0064 15.7 4.1 1.2 1 0 0 1 1 1 1 Timeless protein C terminal region TRAP_alpha PF03896.16 ELR16785.1 - 0.36 10.0 1.9 0.53 9.4 1.9 1.2 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Actin PF00022.19 ELR16786.1 - 6.5e-46 156.7 0.0 3.4e-44 151.1 0.0 2.2 2 0 0 2 2 2 2 Actin DEAD PF00270.29 ELR16787.1 - 2.4e-15 56.7 0.0 1.8e-14 53.9 0.0 2.5 3 0 0 3 3 3 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ELR16787.1 - 7.8e-13 48.8 0.0 4.2e-11 43.2 0.0 3.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain Chromo PF00385.24 ELR16787.1 - 2.6e-12 46.4 6.1 5.8e-06 26.1 0.7 2.8 2 0 0 2 2 2 2 Chromo (CHRromatin Organisation MOdifier) domain RQC PF09382.10 ELR16787.1 - 3.7e-08 33.1 0.1 0.016 15.0 0.0 2.8 2 0 0 2 2 2 2 RQC domain RecQ_Zn_bind PF16124.5 ELR16787.1 - 7.8e-07 29.7 7.6 8e-06 26.5 3.8 3.9 2 0 0 2 2 2 1 RecQ zinc-binding MRP-S24 PF14955.6 ELR16787.1 - 0.053 13.5 0.2 17 5.4 0.0 2.5 2 0 0 2 2 2 0 Mitochondrial ribosome subunit S24 TrmO PF01980.16 ELR16789.1 - 4.2e-41 139.9 0.0 1.6e-40 138.0 0.0 1.9 2 0 0 2 2 2 1 tRNA-methyltransferase O TrmO_C PF18389.1 ELR16789.1 - 1.7e-05 24.8 0.0 2.7e-05 24.2 0.0 1.3 1 0 0 1 1 1 1 TrmO C-terminal domain Arf PF00025.21 ELR16790.1 - 9.5e-65 217.3 0.0 1.1e-64 217.1 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 ELR16790.1 - 9.5e-16 58.1 0.0 1.6e-15 57.3 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase G-alpha PF00503.20 ELR16790.1 - 2.7e-14 53.1 0.6 5.4e-10 39.0 0.1 2.3 1 1 1 2 2 2 2 G-protein alpha subunit Ras PF00071.22 ELR16790.1 - 3e-13 49.7 0.0 3.5e-13 49.5 0.0 1.1 1 0 0 1 1 1 1 Ras family Gtr1_RagA PF04670.12 ELR16790.1 - 2.4e-10 40.2 0.0 3.3e-10 39.7 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.10 ELR16790.1 - 2.9e-08 33.4 0.0 3.6e-08 33.0 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 ELR16790.1 - 8.8e-06 25.8 0.0 1.3e-05 25.2 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 ELR16790.1 - 0.00057 19.5 0.6 0.0046 16.5 0.0 2.0 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain 6PF2K PF01591.18 ELR16790.1 - 0.0021 17.4 0.0 0.0032 16.8 0.0 1.2 1 0 0 1 1 1 1 6-phosphofructo-2-kinase cobW PF02492.19 ELR16790.1 - 0.012 15.2 0.0 0.26 10.9 0.0 2.0 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain NTPase_1 PF03266.15 ELR16790.1 - 0.041 13.8 0.7 4.1 7.3 0.1 2.1 1 1 1 2 2 2 0 NTPase AAA PF00004.29 ELR16790.1 - 0.056 13.9 0.0 0.11 12.9 0.0 1.5 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) FeoB_N PF02421.18 ELR16790.1 - 0.11 12.0 0.1 0.18 11.3 0.1 1.7 1 1 0 1 1 1 0 Ferrous iron transport protein B PduV-EutP PF10662.9 ELR16790.1 - 0.14 11.9 0.0 0.27 11.0 0.0 1.4 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation RhoGEF PF00621.20 ELR16791.1 - 1.1e-41 143.1 0.3 1.7e-41 142.5 0.3 1.3 1 0 0 1 1 1 1 RhoGEF domain Ank_2 PF12796.7 ELR16791.1 - 6.5e-27 93.9 0.1 2.9e-10 40.6 0.0 3.8 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ELR16791.1 - 5.1e-22 77.9 1.6 7.3e-07 29.6 0.0 5.3 2 1 3 5 5 5 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 ELR16791.1 - 6.4e-22 77.3 0.1 6.5e-09 35.9 0.0 3.8 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.30 ELR16791.1 - 1.9e-19 69.2 4.0 5.3e-06 26.6 0.1 5.1 4 1 0 4 4 4 4 Ankyrin repeat Ank_3 PF13606.6 ELR16791.1 - 5.2e-19 66.4 4.0 0.00062 20.0 0.0 6.6 6 1 0 6 6 6 3 Ankyrin repeat PH PF00169.29 ELR16791.1 - 9.2e-05 22.9 0.0 0.00022 21.7 0.0 1.6 1 0 0 1 1 1 1 PH domain IQ_SEC7_PH PF16453.5 ELR16791.1 - 0.006 16.6 0.0 0.013 15.5 0.0 1.5 1 0 0 1 1 1 1 PH domain Glyoxalase_6 PF18029.1 ELR16791.1 - 1.2 9.9 4.6 1.3 9.9 0.3 3.2 3 0 0 3 3 3 0 Glyoxalase-like domain Ras PF00071.22 ELR16792.1 - 5.6e-37 126.8 0.0 8.1e-37 126.3 0.0 1.2 1 0 0 1 1 1 1 Ras family Ank_4 PF13637.6 ELR16792.1 - 7.9e-19 67.8 0.2 2.3e-05 24.8 0.0 4.1 4 1 1 5 5 4 3 Ankyrin repeats (many copies) Roc PF08477.13 ELR16792.1 - 9.9e-19 67.7 0.0 1.6e-18 67.0 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ank_2 PF12796.7 ELR16792.1 - 1.2e-18 67.5 0.8 3.9e-12 46.6 0.0 3.0 3 0 0 3 3 3 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 ELR16792.1 - 7.9e-17 59.6 0.6 0.00023 21.4 0.1 5.0 4 0 0 4 4 4 4 Ankyrin repeat Ank PF00023.30 ELR16792.1 - 1e-14 54.2 1.3 3.6e-05 24.0 0.2 4.7 4 0 0 4 4 4 2 Ankyrin repeat Ank_5 PF13857.6 ELR16792.1 - 8.9e-14 51.4 1.1 0.00067 19.9 0.0 3.6 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Arf PF00025.21 ELR16792.1 - 1.5e-06 27.8 0.0 2.3e-06 27.2 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family F-box-like PF12937.7 ELR16792.1 - 3.2e-05 23.7 0.0 0.00026 20.8 0.0 2.3 2 0 0 2 2 2 1 F-box-like F-box_4 PF15966.5 ELR16792.1 - 8e-05 22.5 0.3 0.00018 21.4 0.0 1.8 2 0 0 2 2 2 1 F-box F-box PF00646.33 ELR16792.1 - 0.00011 21.9 0.0 0.0003 20.6 0.0 1.6 1 0 0 1 1 1 1 F-box domain MMR_HSR1 PF01926.23 ELR16792.1 - 0.0025 17.9 0.0 0.0043 17.1 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase UMP1 PF05348.11 ELR16793.1 - 6.7e-23 81.2 0.0 7.9e-23 80.9 0.0 1.0 1 0 0 1 1 1 1 Proteasome maturation factor UMP1 Myosin_head PF00063.21 ELR16794.1 - 1.5e-228 760.4 0.0 2.9e-228 759.5 0.0 1.5 1 1 0 1 1 1 1 Myosin head (motor domain) MyTH4 PF00784.17 ELR16794.1 - 2.5e-23 82.6 0.0 7.3e-23 81.1 0.0 1.8 1 0 0 1 1 1 1 MyTH4 domain WW PF00397.26 ELR16794.1 - 1.8e-07 31.1 1.9 1.8e-07 31.1 1.9 1.8 2 0 0 2 2 2 1 WW domain ABC_tran PF00005.27 ELR16794.1 - 0.0043 17.6 0.1 0.076 13.5 0.0 2.8 2 0 0 2 2 2 1 ABC transporter AAA_16 PF13191.6 ELR16794.1 - 0.018 15.4 0.0 0.095 13.1 0.0 2.3 2 0 0 2 2 2 0 AAA ATPase domain CDC37_C PF08564.10 ELR16794.1 - 0.023 14.8 0.3 10 6.3 0.0 2.9 2 0 0 2 2 2 0 Cdc37 C terminal domain Hpr_kinase_C PF07475.12 ELR16794.1 - 0.11 12.1 0.2 13 5.3 0.0 2.5 2 0 0 2 2 2 0 HPr Serine kinase C-terminal domain Myosin_N PF02736.19 ELR16794.1 - 0.3 10.9 1.4 0.66 9.9 1.4 1.6 1 0 0 1 1 1 0 Myosin N-terminal SH3-like domain DUF3325 PF11804.8 ELR16795.1 - 0.077 13.2 0.5 2.2 8.5 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3325) CBS PF00571.28 ELR16796.1 - 7.3e-21 74.4 5.4 4.3e-06 27.1 0.4 4.4 4 0 0 4 4 4 4 CBS domain dbPDZ_assoc PF16610.5 ELR16796.1 - 0.12 12.6 0.1 0.26 11.6 0.1 1.4 1 0 0 1 1 1 0 Unstructured region between two PDZ domains on Dlg5 SAP PF02037.27 ELR16797.1 - 1.2e-11 44.0 0.0 2.5e-11 43.1 0.0 1.6 1 0 0 1 1 1 1 SAP domain SMI1_KNR4 PF09346.10 ELR16797.1 - 9.8e-08 32.5 1.8 1.4e-06 28.7 0.1 2.3 2 0 0 2 2 2 1 SMI1 / KNR4 family (SUKH-1) BUD22 PF09073.10 ELR16797.1 - 0.00055 19.4 2.7 0.00057 19.4 2.7 1.3 1 0 0 1 1 1 1 BUD22 SUKH_5 PF14567.6 ELR16797.1 - 0.0073 16.1 0.0 0.22 11.3 0.0 2.3 2 1 0 2 2 2 1 SMI1-KNR4 cell-wall DNA_pol_phi PF04931.13 ELR16797.1 - 0.011 13.9 12.8 0.015 13.5 12.8 1.1 1 0 0 1 1 1 0 DNA polymerase phi SUKH_6 PF14568.6 ELR16797.1 - 0.017 15.6 1.4 0.039 14.4 0.0 2.3 2 1 0 2 2 2 0 SMI1-KNR4 cell-wall SDA1 PF05285.12 ELR16797.1 - 0.025 14.0 9.1 0.034 13.6 9.1 1.3 1 0 0 1 1 1 0 SDA1 Nop14 PF04147.12 ELR16797.1 - 0.042 12.1 10.6 0.048 11.9 10.6 1.1 1 0 0 1 1 1 0 Nop14-like family Sigma70_ner PF04546.13 ELR16797.1 - 0.05 13.5 4.6 0.075 12.9 4.6 1.3 1 0 0 1 1 1 0 Sigma-70, non-essential region Myc_N PF01056.18 ELR16797.1 - 0.12 12.3 5.2 0.17 11.8 5.2 1.2 1 0 0 1 1 1 0 Myc amino-terminal region DUF4518 PF15008.6 ELR16797.1 - 0.13 11.4 0.1 0.17 11.0 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4518) SpoIIIAH PF12685.7 ELR16797.1 - 0.15 11.9 5.6 0.24 11.2 5.6 1.3 1 0 0 1 1 1 0 SpoIIIAH-like protein Tim54 PF11711.8 ELR16797.1 - 0.27 10.0 2.7 0.34 9.7 2.7 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 NPR3 PF03666.13 ELR16797.1 - 0.27 10.0 2.4 0.39 9.4 2.4 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 PPP4R2 PF09184.11 ELR16797.1 - 0.28 10.7 9.5 0.41 10.2 9.5 1.2 1 0 0 1 1 1 0 PPP4R2 AF-4 PF05110.13 ELR16797.1 - 0.29 9.2 7.7 0.33 9.0 7.7 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein CDC45 PF02724.14 ELR16797.1 - 0.43 8.8 6.7 0.56 8.4 6.7 1.1 1 0 0 1 1 1 0 CDC45-like protein CobT PF06213.12 ELR16797.1 - 0.51 9.7 12.9 0.8 9.0 12.9 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT NOA36 PF06524.12 ELR16797.1 - 0.58 9.4 9.5 1 8.6 9.5 1.3 1 0 0 1 1 1 0 NOA36 protein Presenilin PF01080.17 ELR16797.1 - 0.73 8.5 2.6 0.87 8.3 2.6 1.1 1 0 0 1 1 1 0 Presenilin Paf1 PF03985.13 ELR16797.1 - 2.7 6.9 9.6 4.4 6.2 9.6 1.3 1 0 0 1 1 1 0 Paf1 TFB6 PF17110.5 ELR16797.1 - 3 7.6 6.1 5 6.8 6.1 1.4 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH Ras PF00071.22 ELR16798.1 - 2.9e-43 147.3 0.0 4.5e-43 146.7 0.0 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR16798.1 - 3.5e-18 66.0 0.0 5.8e-18 65.3 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ank_2 PF12796.7 ELR16798.1 - 2.2e-15 57.0 0.1 4.9e-15 55.9 0.1 1.6 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 ELR16798.1 - 4.1e-14 51.3 0.2 2.2e-05 24.5 0.0 3.9 3 0 0 3 3 3 2 Ankyrin repeat Ank PF00023.30 ELR16798.1 - 5.7e-14 51.8 1.1 3.4e-06 27.2 0.2 3.6 3 0 0 3 3 3 2 Ankyrin repeat Ank_5 PF13857.6 ELR16798.1 - 1.2e-12 47.8 0.3 4.1e-05 23.8 0.0 2.8 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 ELR16798.1 - 5.2e-12 46.0 0.4 0.00017 22.1 0.0 2.6 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Arf PF00025.21 ELR16798.1 - 6.6e-07 28.9 0.0 1e-06 28.3 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family F-box-like PF12937.7 ELR16798.1 - 0.00033 20.5 6.9 0.00075 19.3 3.3 2.5 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 ELR16798.1 - 0.0065 16.3 3.7 0.013 15.3 3.7 1.6 1 0 0 1 1 1 1 F-box domain F-box_4 PF15966.5 ELR16798.1 - 0.06 13.2 0.1 0.11 12.4 0.1 1.4 1 0 0 1 1 1 0 F-box GATase_4 PF13230.6 ELR16799.1 - 8.3e-11 41.3 0.0 6.3e-10 38.4 0.0 2.0 2 0 0 2 2 2 1 Glutamine amidotransferases class-II GATase_6 PF13522.6 ELR16799.1 - 7.1e-08 32.7 0.0 2e-07 31.2 0.0 1.7 1 1 0 1 1 1 1 Glutamine amidotransferase domain Ras PF00071.22 ELR16800.1 - 6.8e-40 136.3 0.0 8.2e-40 136.0 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR16800.1 - 8.7e-09 35.6 0.0 1.8e-08 34.6 0.0 1.5 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR16800.1 - 0.0024 17.3 0.0 0.003 17.0 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family ATP_bind_1 PF03029.17 ELR16800.1 - 0.052 13.3 0.0 5.7 6.6 0.0 2.1 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein Septin PF00735.18 ELR16800.1 - 0.1 11.8 0.0 0.15 11.4 0.0 1.2 1 0 0 1 1 1 0 Septin NB-ARC PF00931.22 ELR16800.1 - 0.19 10.9 0.0 0.39 9.8 0.0 1.5 2 0 0 2 2 2 0 NB-ARC domain RFX_DNA_binding PF02257.15 ELR16801.1 - 2.4e-17 63.3 0.0 4.5e-17 62.4 0.0 1.4 1 0 0 1 1 1 1 RFX DNA-binding domain Pox_D5 PF03288.16 ELR16801.1 - 0.05 14.1 0.0 0.094 13.2 0.0 1.4 1 0 0 1 1 1 0 Poxvirus D5 protein-like BSP_II PF05432.11 ELR16801.1 - 0.3 10.7 11.9 1.2 8.8 1.3 2.4 2 0 0 2 2 2 0 Bone sialoprotein II (BSP-II) PBP1_TM PF14812.6 ELR16801.1 - 1.4 9.3 10.8 18 5.8 6.9 2.8 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal HRG PF16954.5 ELR16802.1 - 0.00054 20.3 7.2 0.00054 20.3 7.2 2.3 2 0 0 2 2 2 1 Haem-transporter, endosomal/lysosomal, haem-responsive gene SAP PF02037.27 ELR16803.1 - 9.2e-25 85.9 15.6 8.4e-11 41.4 0.4 3.7 3 0 0 3 3 3 3 SAP domain Telomere_Sde2_2 PF13297.6 ELR16803.1 - 0.0014 18.2 2.3 0.26 11.0 0.2 2.7 2 0 0 2 2 2 2 Telomere stability C-terminal Rho_N PF07498.12 ELR16803.1 - 0.11 12.4 9.4 1.4 8.9 0.3 3.6 3 0 0 3 3 3 0 Rho termination factor, N-terminal domain HeH PF12949.7 ELR16803.1 - 3.1 7.6 5.8 0.42 10.4 0.2 2.5 4 0 0 4 4 4 0 HeH/LEM domain PIG-L PF02585.17 ELR16804.1 - 4.7e-23 82.2 0.0 7e-23 81.7 0.0 1.3 1 0 0 1 1 1 1 GlcNAc-PI de-N-acetylase F-box-like PF12937.7 ELR16805.1 - 5.8e-05 22.9 0.6 0.00011 22.0 0.6 1.4 1 0 0 1 1 1 1 F-box-like Ras PF00071.22 ELR16806.1 - 1.3e-50 171.2 0.0 1.5e-50 171.0 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR16806.1 - 4.1e-23 81.9 0.0 6.8e-23 81.2 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR16806.1 - 7.6e-07 28.7 0.0 1.3e-06 28.0 0.0 1.4 1 1 0 1 1 1 1 ADP-ribosylation factor family Peptidase_S28 PF05577.12 ELR16807.1 - 4.9e-78 262.9 0.0 5.7e-78 262.6 0.0 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase S28 Hydrolase_4 PF12146.8 ELR16807.1 - 6.9e-05 22.2 0.0 0.00017 21.0 0.0 1.6 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Peptidase_S9 PF00326.21 ELR16807.1 - 0.015 14.7 0.0 0.03 13.8 0.0 1.4 1 0 0 1 1 1 0 Prolyl oligopeptidase family DUF2437 PF10370.9 ELR16808.1 - 0.2 12.6 11.9 19 6.3 0.1 3.7 2 1 0 2 2 2 0 Domain of unknown function (DUF2437) Biotin_lipoyl PF00364.22 ELR16808.1 - 1.9 8.4 7.0 3.4 7.6 1.3 2.9 1 1 1 2 2 2 0 Biotin-requiring enzyme Podoplanin PF05808.11 ELR16809.1 - 0.01 15.9 0.2 0.019 15.1 0.2 1.4 1 0 0 1 1 1 0 Podoplanin Mucin PF01456.17 ELR16809.1 - 0.041 13.9 0.0 0.069 13.1 0.0 1.4 1 0 0 1 1 1 0 Mucin-like glycoprotein GTP_EFTU PF00009.27 ELR16810.1 - 5.6e-17 61.9 0.0 9.1e-17 61.2 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_II PF14492.6 ELR16810.1 - 0.0081 16.2 0.0 0.014 15.5 0.0 1.3 1 0 0 1 1 1 1 Elongation Factor G, domain II EFG_IV PF03764.18 ELR16810.1 - 0.18 11.6 0.0 0.41 10.4 0.0 1.6 1 0 0 1 1 1 0 Elongation factor G, domain IV Ribosomal_L32e PF01655.18 ELR16811.1 - 1.8e-49 166.7 1.6 2.1e-49 166.4 1.6 1.1 1 0 0 1 1 1 1 Ribosomal protein L32 PRP21_like_P PF12230.8 ELR16812.1 - 1e-33 117.1 9.3 1.1e-16 61.4 4.5 2.7 1 1 1 2 2 2 2 Pre-mRNA splicing factor PRP21 like protein Surp PF01805.20 ELR16812.1 - 1.7e-19 69.5 2.9 4.9e-17 61.7 0.9 2.5 2 0 0 2 2 2 2 Surp module ubiquitin PF00240.23 ELR16812.1 - 3.3e-08 33.2 0.0 7.9e-08 32.0 0.0 1.7 1 0 0 1 1 1 1 Ubiquitin family zf_UBZ PF18439.1 ELR16812.1 - 0.00072 19.1 0.5 0.0015 18.1 0.5 1.6 1 0 0 1 1 1 1 Ubiquitin-Binding Zinc Finger zf-dskA_traR PF01258.17 ELR16812.1 - 0.078 12.9 0.4 0.17 11.9 0.4 1.5 1 0 0 1 1 1 0 Prokaryotic dksA/traR C4-type zinc finger Lung_7-TM_R PF06814.13 ELR16814.1 - 2.6e-52 177.9 10.1 4e-52 177.3 10.1 1.3 1 0 0 1 1 1 1 Lung seven transmembrane receptor GEMIN8 PF15348.6 ELR16815.1 - 6.4e-06 26.6 0.4 8.4e-06 26.3 0.4 1.2 1 0 0 1 1 1 1 Gemini of Cajal bodies-associated protein 8 Rrn6 PF10214.9 ELR16815.1 - 0.25 9.8 2.4 0.29 9.6 2.4 1.0 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor Spt5_N PF11942.8 ELR16815.1 - 9.2 7.3 12.4 10 7.2 11.1 1.7 1 1 1 2 2 2 0 Spt5 transcription elongation factor, acidic N-terminal Ank_2 PF12796.7 ELR16816.1 - 2.1e-97 319.8 14.1 2.3e-12 47.3 0.0 14.3 8 5 7 15 15 15 13 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ELR16816.1 - 2.5e-87 286.2 21.6 3e-08 34.0 0.0 19.1 14 6 6 20 20 20 17 Ankyrin repeats (many copies) Ank_5 PF13857.6 ELR16816.1 - 2e-77 254.2 27.1 1.3e-10 41.3 0.0 15.5 13 3 3 16 16 16 13 Ankyrin repeats (many copies) Ank_3 PF13606.6 ELR16816.1 - 8.2e-68 216.3 21.0 4.2e-05 23.6 0.0 23.4 24 0 0 24 24 24 12 Ankyrin repeat Ank PF00023.30 ELR16816.1 - 1e-64 212.3 33.5 1.8e-06 28.2 0.1 20.8 24 0 0 24 24 24 14 Ankyrin repeat Sec31 PF11549.8 ELR16816.1 - 0.11 12.4 0.3 8.4 6.4 0.1 3.1 2 0 0 2 2 2 0 Protein transport protein SEC31 Ndc1_Nup PF09531.10 ELR16816.1 - 0.33 9.6 3.2 1.6 7.3 1.7 2.1 2 0 0 2 2 2 0 Nucleoporin protein Ndc1-Nup Lon_C PF05362.13 ELR16818.1 - 5.5e-58 195.9 0.0 6e-43 146.8 0.0 3.9 3 1 0 4 4 4 3 Lon protease (S16) C-terminal proteolytic domain AAA PF00004.29 ELR16818.1 - 3.2e-24 85.8 0.3 2.1e-23 83.2 0.0 2.3 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) LON_substr_bdg PF02190.16 ELR16818.1 - 1.4e-13 51.3 0.1 3.6e-13 49.9 0.1 1.8 1 0 0 1 1 1 1 ATP-dependent protease La (LON) substrate-binding domain AAA_5 PF07728.14 ELR16818.1 - 4.8e-09 36.3 0.0 2.1e-08 34.2 0.0 2.1 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 ELR16818.1 - 1.9e-07 31.4 0.0 7e-07 29.5 0.0 2.0 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.6 ELR16818.1 - 2.8e-05 24.4 1.1 0.0096 16.2 0.0 3.6 2 1 0 2 2 2 1 AAA domain ChlI PF13541.6 ELR16818.1 - 8e-05 22.5 0.2 0.00025 20.9 0.0 1.9 2 0 0 2 2 2 1 Subunit ChlI of Mg-chelatase AAA_16 PF13191.6 ELR16818.1 - 0.00057 20.3 0.5 0.0046 17.4 0.0 2.7 2 1 0 2 2 2 1 AAA ATPase domain MCM PF00493.23 ELR16818.1 - 0.0036 16.4 0.0 0.0086 15.2 0.0 1.6 1 0 0 1 1 1 1 MCM P-loop domain AAA_14 PF13173.6 ELR16818.1 - 0.0042 17.1 0.0 0.013 15.5 0.0 1.9 1 0 0 1 1 1 1 AAA domain RNA_helicase PF00910.22 ELR16818.1 - 0.008 16.6 0.0 0.017 15.5 0.0 1.6 1 0 0 1 1 1 1 RNA helicase AAA_30 PF13604.6 ELR16818.1 - 0.0081 15.9 0.0 0.023 14.4 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 ELR16818.1 - 0.013 16.0 0.0 0.013 16.0 0.0 2.9 3 0 0 3 3 3 0 AAA domain AAA_23 PF13476.6 ELR16818.1 - 0.014 15.9 8.7 0.18 12.3 0.3 3.4 2 1 0 2 2 2 0 AAA domain NTPase_1 PF03266.15 ELR16818.1 - 0.019 14.9 0.9 0.045 13.7 0.1 2.1 2 1 0 2 2 1 0 NTPase IstB_IS21 PF01695.17 ELR16818.1 - 0.022 14.5 0.1 0.08 12.7 0.0 1.9 2 0 0 2 2 2 0 IstB-like ATP binding protein RuvB_N PF05496.12 ELR16818.1 - 0.029 14.1 0.0 0.074 12.8 0.0 1.6 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain AAA_PrkA PF08298.11 ELR16818.1 - 0.051 12.5 0.0 0.099 11.5 0.0 1.4 1 0 0 1 1 1 0 PrkA AAA domain ABC_tran PF00005.27 ELR16818.1 - 0.08 13.5 0.9 0.68 10.5 0.0 2.7 2 0 0 2 2 2 0 ABC transporter AAA_3 PF07726.11 ELR16818.1 - 0.11 12.4 0.0 0.27 11.1 0.0 1.7 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) SKI PF01202.22 ELR16818.1 - 0.12 12.5 2.9 0.14 12.3 0.0 2.6 3 0 0 3 3 2 0 Shikimate kinase AAA_7 PF12775.7 ELR16818.1 - 0.14 11.7 0.0 0.3 10.6 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region RXT2_N PF08595.11 ELR16818.1 - 0.16 12.0 9.4 0.84 9.7 1.0 2.8 2 0 0 2 2 2 0 RXT2-like, N-terminal SnoaL_2 PF12680.7 ELR16819.1 - 0.012 16.3 0.7 0.75 10.5 0.0 3.1 2 2 0 2 2 2 0 SnoaL-like domain UBM PF14377.6 ELR16819.1 - 0.11 12.0 4.6 3.4 7.2 0.2 3.9 4 0 0 4 4 4 0 Ubiquitin binding region Acetyltransf_7 PF13508.7 ELR16820.1 - 3.8e-09 36.9 0.0 5.5e-09 36.3 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 ELR16820.1 - 2.6e-08 33.8 0.0 3.5e-08 33.4 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 ELR16820.1 - 5.6e-07 29.8 0.0 7e-07 29.5 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_9 PF13527.7 ELR16820.1 - 3.6e-05 23.8 0.0 6.2e-05 23.1 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 ELR16820.1 - 0.0014 18.5 0.0 0.0037 17.2 0.0 1.7 1 1 0 1 1 1 1 FR47-like protein Acetyltransf_4 PF13420.7 ELR16820.1 - 0.008 16.3 0.0 0.013 15.7 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain CDI PF02234.19 ELR16821.1 - 0.072 13.3 0.5 0.21 11.8 0.5 1.7 1 1 0 1 1 1 0 Cyclin-dependent kinase inhibitor RabGAP-TBC PF00566.18 ELR16823.1 - 2.9e-24 85.9 0.2 4.7e-24 85.2 0.2 1.3 1 0 0 1 1 1 1 Rab-GTPase-TBC domain Rhodanese PF00581.20 ELR16823.1 - 2.7e-07 31.0 0.0 1e-06 29.2 0.0 2.0 1 0 0 1 1 1 1 Rhodanese-like domain NDUF_B4 PF07225.12 ELR16824.1 - 0.0021 17.9 0.1 0.0025 17.7 0.1 1.1 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase B15 subunit (NDUFB4) ATP-sulfurylase PF01747.17 ELR16825.1 - 4.6e-80 268.1 0.1 2e-79 266.0 0.1 2.0 2 0 0 2 2 2 1 ATP-sulfurylase APS_kinase PF01583.20 ELR16825.1 - 1.6e-56 190.5 0.0 3e-56 189.7 0.0 1.4 1 0 0 1 1 1 1 Adenylylsulphate kinase PUA_2 PF14306.6 ELR16825.1 - 4.1e-52 176.0 0.0 6.6e-52 175.4 0.0 1.3 1 0 0 1 1 1 1 PUA-like domain AAA_33 PF13671.6 ELR16825.1 - 0.0017 18.6 0.0 0.0041 17.3 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_29 PF13555.6 ELR16825.1 - 0.0033 17.1 0.0 0.0077 15.9 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain KTI12 PF08433.10 ELR16825.1 - 0.0035 16.9 0.0 0.0056 16.2 0.0 1.3 1 0 0 1 1 1 1 Chromatin associated protein KTI12 AAA_16 PF13191.6 ELR16825.1 - 0.033 14.6 0.2 0.066 13.6 0.2 1.5 1 0 0 1 1 1 0 AAA ATPase domain AAA_18 PF13238.6 ELR16825.1 - 0.06 13.9 0.0 0.14 12.7 0.0 1.7 1 0 0 1 1 1 0 AAA domain CPT PF07931.12 ELR16825.1 - 0.071 12.9 0.1 0.2 11.5 0.1 1.8 1 0 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein MeaB PF03308.16 ELR16825.1 - 0.11 11.4 0.0 0.22 10.5 0.0 1.4 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Lung_7-TM_R PF06814.13 ELR16827.1 - 6.7e-10 38.7 13.9 1.1e-09 38.0 13.9 1.3 1 0 0 1 1 1 1 Lung seven transmembrane receptor GpcrRhopsn4 PF10192.9 ELR16827.1 - 0.82 9.0 18.9 0.57 9.5 17.3 1.5 1 1 1 2 2 2 0 Rhodopsin-like GPCR transmembrane domain Pkinase PF00069.25 ELR16828.1 - 2.8e-70 236.7 0.0 2.4e-69 233.6 0.0 2.1 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR16828.1 - 2.3e-48 164.7 0.0 3.6e-48 164.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase PH PF00169.29 ELR16828.1 - 2e-22 79.6 0.9 4.1e-22 78.7 0.9 1.5 1 0 0 1 1 1 1 PH domain PBD PF00786.28 ELR16828.1 - 2.4e-14 53.4 0.4 2.5e-13 50.2 0.0 2.7 3 0 0 3 3 3 1 P21-Rho-binding domain Pkinase_fungal PF17667.1 ELR16828.1 - 2.9e-07 29.6 0.0 6.6e-07 28.4 0.0 1.5 1 0 0 1 1 1 1 Fungal protein kinase PH_11 PF15413.6 ELR16828.1 - 7.7e-07 29.5 4.0 1.8e-06 28.3 4.0 1.6 1 0 0 1 1 1 1 Pleckstrin homology domain PH_9 PF15410.6 ELR16828.1 - 4.1e-06 27.2 2.9 1.3e-05 25.6 2.9 1.8 1 1 0 1 1 1 1 Pleckstrin homology domain PH_8 PF15409.6 ELR16828.1 - 1.5e-05 25.2 1.8 3.1e-05 24.2 1.8 1.5 1 0 0 1 1 1 1 Pleckstrin homology domain Kinase-like PF14531.6 ELR16828.1 - 0.011 15.1 0.1 0.14 11.5 0.0 2.3 2 0 0 2 2 2 0 Kinase-like PH_13 PF16652.5 ELR16828.1 - 0.074 12.9 0.5 0.14 12.0 0.5 1.4 1 0 0 1 1 1 0 Pleckstrin homology domain AAA_5 PF07728.14 ELR16828.1 - 0.084 12.9 0.1 0.28 11.2 0.0 2.0 3 0 0 3 3 3 0 AAA domain (dynein-related subfamily) LRR_6 PF13516.6 ELR16829.1 - 4.6e-16 57.4 12.1 9.5e-05 22.2 0.1 8.2 9 0 0 9 9 9 4 Leucine Rich repeat LRR_1 PF00560.33 ELR16829.1 - 0.00012 22.1 1.9 6.8 7.7 0.0 7.1 7 1 0 7 7 7 1 Leucine Rich Repeat LRR_8 PF13855.6 ELR16829.1 - 0.00051 19.7 2.4 0.32 10.8 0.0 4.7 5 0 0 5 5 5 1 Leucine rich repeat LRR_4 PF12799.7 ELR16829.1 - 0.0024 18.3 2.2 0.36 11.3 0.2 4.8 3 1 2 5 5 5 3 Leucine Rich repeats (2 copies) 7TM_GPCR_Sra PF02117.16 ELR16829.1 - 0.14 10.9 0.0 0.26 10.1 0.0 1.3 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Sra FKBP_C PF00254.28 ELR16830.1 - 5.8e-47 158.0 0.0 5.4e-31 106.8 0.0 2.4 2 0 0 2 2 2 2 FKBP-type peptidyl-prolyl cis-trans isomerase TPR_1 PF00515.28 ELR16830.1 - 3.1e-06 26.8 6.9 0.0086 15.9 1.0 3.5 2 1 1 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 ELR16830.1 - 2.5e-05 24.0 3.7 0.59 10.4 0.2 3.6 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.6 ELR16830.1 - 0.00032 20.3 0.2 0.02 14.6 0.0 2.7 2 0 0 2 2 2 1 TPR repeat TPR_14 PF13428.6 ELR16830.1 - 0.01 16.6 0.1 0.17 12.8 0.5 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF3673 PF12425.8 ELR16830.1 - 0.014 15.2 0.0 0.03 14.2 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3673) TPR_16 PF13432.6 ELR16830.1 - 0.015 16.0 0.2 19 6.0 0.0 3.4 2 1 1 3 3 3 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 ELR16830.1 - 0.023 14.8 3.1 1 9.5 0.3 2.8 1 1 1 2 2 2 0 Fis1 C-terminal tetratricopeptide repeat NRBF2_MIT PF17169.4 ELR16830.1 - 0.031 14.5 0.2 0.083 13.1 0.2 1.8 1 0 0 1 1 1 0 MIT domain of nuclear receptor-binding factor 2 TPR_12 PF13424.6 ELR16830.1 - 0.048 14.0 0.3 0.44 10.9 0.4 2.3 2 1 0 2 2 2 0 Tetratricopeptide repeat TPR_19 PF14559.6 ELR16830.1 - 0.12 12.8 2.1 2.4 8.8 0.3 3.0 2 1 1 3 3 3 0 Tetratricopeptide repeat Peptidase_S9 PF00326.21 ELR16831.1 - 3.1e-32 111.8 0.0 5e-32 111.1 0.0 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family DLH PF01738.18 ELR16831.1 - 4.7e-07 29.6 0.0 1.7e-06 27.7 0.0 1.8 1 1 0 1 1 1 1 Dienelactone hydrolase family Abhydrolase_1 PF00561.20 ELR16831.1 - 8.6e-06 25.6 0.5 0.031 13.9 0.0 2.5 1 1 1 2 2 2 2 alpha/beta hydrolase fold Peptidase_S15 PF02129.18 ELR16831.1 - 5.2e-05 23.0 0.0 0.03 13.9 0.0 2.3 1 1 1 2 2 2 2 X-Pro dipeptidyl-peptidase (S15 family) Hydrolase_4 PF12146.8 ELR16831.1 - 5.4e-05 22.6 0.0 0.071 12.4 0.0 2.3 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Peptidase_S9_N PF02897.15 ELR16831.1 - 0.00042 19.2 0.0 0.0057 15.5 0.0 2.4 1 1 0 1 1 1 1 Prolyl oligopeptidase, N-terminal beta-propeller domain DPPIV_N PF00930.21 ELR16831.1 - 0.00055 18.8 0.0 0.17 10.6 0.0 2.6 2 1 1 3 3 3 2 Dipeptidyl peptidase IV (DPP IV) N-terminal region AXE1 PF05448.12 ELR16831.1 - 0.0014 17.3 0.1 0.56 8.8 0.0 2.2 1 1 1 2 2 2 2 Acetyl xylan esterase (AXE1) Abhydrolase_3 PF07859.13 ELR16831.1 - 0.012 15.4 0.0 0.05 13.5 0.0 1.8 1 1 0 1 1 1 0 alpha/beta hydrolase fold PD40 PF07676.12 ELR16831.1 - 0.84 9.7 8.2 9.6 6.3 0.3 5.0 6 0 0 6 6 6 0 WD40-like Beta Propeller Repeat Glyoxalase PF00903.25 ELR16832.1 - 3.6e-09 36.9 0.0 7.6e-09 35.8 0.0 1.5 1 1 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_3 PF13468.6 ELR16832.1 - 0.00051 20.2 0.0 0.013 15.7 0.0 2.0 1 1 0 1 1 1 1 Glyoxalase-like domain Glyoxalase_4 PF13669.6 ELR16832.1 - 0.012 15.9 0.0 0.021 15.1 0.0 1.4 1 1 0 1 1 1 0 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_2 PF12681.7 ELR16832.1 - 0.019 14.9 0.0 4.3 7.3 0.0 2.2 2 0 0 2 2 2 0 Glyoxalase-like domain WD40 PF00400.32 ELR16833.1 - 5.8e-12 45.9 0.6 0.011 16.5 0.0 4.1 4 0 0 4 4 4 3 WD domain, G-beta repeat Ge1_WD40 PF16529.5 ELR16833.1 - 0.0063 15.5 0.0 0.56 9.1 0.0 2.9 2 1 1 3 3 3 1 WD40 region of Ge1, enhancer of mRNA-decapping protein ANAPC4_WD40 PF12894.7 ELR16833.1 - 0.0087 16.3 0.0 6.4 7.1 0.1 3.7 2 2 1 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain Archease PF01951.16 ELR16834.1 - 1.4e-35 122.5 0.1 1.8e-35 122.2 0.1 1.1 1 0 0 1 1 1 1 Archease protein family (MTH1598/TM1083) Methyltransf_11 PF08241.12 ELR16836.1 - 2.5e-08 34.5 0.1 5.4e-08 33.4 0.0 1.5 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 ELR16836.1 - 0.0013 19.4 0.1 0.003 18.2 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 ELR16836.1 - 0.15 12.8 0.0 0.28 12.0 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Exo_endo_phos PF03372.23 ELR16837.1 - 7.6e-10 38.7 0.6 1.5e-09 37.7 0.6 1.5 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family G6PD_C PF02781.16 ELR16838.1 - 4.8e-115 383.7 0.0 6.9e-115 383.2 0.0 1.2 1 0 0 1 1 1 1 Glucose-6-phosphate dehydrogenase, C-terminal domain G6PD_N PF00479.22 ELR16838.1 - 4.4e-60 203.3 0.0 8.3e-60 202.4 0.0 1.5 1 0 0 1 1 1 1 Glucose-6-phosphate dehydrogenase, NAD binding domain Herpes_BLRF2 PF05812.12 ELR16838.1 - 0.013 15.6 0.2 0.026 14.7 0.2 1.5 1 0 0 1 1 1 0 Herpesvirus BLRF2 protein NYD-SP28_assoc PF14775.6 ELR16838.1 - 0.26 11.4 1.3 0.65 10.1 1.3 1.7 1 0 0 1 1 1 0 Sperm tail C-terminal domain Pox_A_type_inc PF04508.12 ELR16838.1 - 3.4 7.7 6.0 9.7 6.2 3.0 2.5 2 0 0 2 2 2 0 Viral A-type inclusion protein repeat Radical_SAM PF04055.21 ELR16839.1 - 7.3e-17 62.2 0.1 3.3e-10 40.6 0.0 2.2 2 0 0 2 2 2 2 Radical SAM superfamily Fer4_14 PF13394.6 ELR16839.1 - 5.6e-05 23.2 0.1 0.13 12.4 0.0 2.4 2 0 0 2 2 2 2 4Fe-4S single cluster domain Fer4_12 PF13353.6 ELR16839.1 - 0.027 14.7 1.7 0.31 11.3 0.9 2.6 2 1 0 2 2 2 0 4Fe-4S single cluster domain Lipoprotein_3 PF00938.17 ELR16839.1 - 0.11 12.7 0.2 3.3 8.0 0.0 2.4 2 0 0 2 2 2 0 Lipoprotein SLX9 PF15341.6 ELR16840.1 - 9.1e-14 52.0 19.5 9.1e-14 52.0 19.5 2.1 2 0 0 2 2 2 1 Ribosome biogenesis protein SLX9 DUF1387 PF07139.11 ELR16840.1 - 2.6 7.7 17.9 3.8 7.2 17.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) Ras PF00071.22 ELR16841.1 - 1.7e-54 183.8 0.0 2e-54 183.6 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR16841.1 - 9.1e-31 106.6 0.0 1.3e-30 106.1 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR16841.1 - 1.7e-11 43.9 0.0 2e-11 43.6 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 ELR16841.1 - 8.6e-06 25.8 0.0 1.5e-05 25.1 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 ELR16841.1 - 2.3e-05 24.0 0.0 0.0024 17.4 0.0 2.4 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 ELR16841.1 - 0.00024 20.5 0.0 0.00032 20.1 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region AAA_22 PF13401.6 ELR16841.1 - 0.00084 19.6 0.0 0.0022 18.3 0.0 1.7 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 ELR16841.1 - 0.0016 18.9 0.0 0.0064 16.9 0.0 1.8 1 1 0 1 1 1 1 AAA ATPase domain PduV-EutP PF10662.9 ELR16841.1 - 0.002 17.9 0.0 0.022 14.5 0.0 2.1 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation ATP_bind_1 PF03029.17 ELR16841.1 - 0.0025 17.6 0.1 0.28 10.9 0.0 2.4 1 1 1 2 2 2 1 Conserved hypothetical ATP binding protein RsgA_GTPase PF03193.16 ELR16841.1 - 0.0031 17.4 0.1 0.04 13.8 0.1 2.2 1 1 0 2 2 2 1 RsgA GTPase AAA_24 PF13479.6 ELR16841.1 - 0.016 14.9 0.0 0.025 14.3 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 ELR16841.1 - 0.038 13.5 0.1 0.058 12.9 0.1 1.2 1 0 0 1 1 1 0 P-loop containing dynein motor region cobW PF02492.19 ELR16841.1 - 0.058 13.0 0.1 1.1 8.8 0.0 2.1 1 1 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain NACHT PF05729.12 ELR16841.1 - 0.093 12.6 0.0 0.15 11.9 0.0 1.3 1 0 0 1 1 1 0 NACHT domain Septin PF00735.18 ELR16841.1 - 0.093 12.0 0.0 0.17 11.1 0.0 1.5 1 0 0 1 1 1 0 Septin AAA_33 PF13671.6 ELR16841.1 - 0.1 12.8 0.0 0.14 12.3 0.0 1.4 1 0 0 1 1 1 0 AAA domain TniB PF05621.11 ELR16841.1 - 0.1 12.0 0.0 0.15 11.5 0.0 1.3 1 0 0 1 1 1 0 Bacterial TniB protein NB-ARC PF00931.22 ELR16841.1 - 0.13 11.4 0.2 0.21 10.8 0.2 1.3 1 0 0 1 1 1 0 NB-ARC domain ATPase_2 PF01637.18 ELR16841.1 - 0.16 11.9 0.1 0.28 11.0 0.1 1.4 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea UQ_con PF00179.26 ELR16842.1 - 4.3e-18 65.3 0.0 8.2e-18 64.4 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme SKG6 PF08693.10 ELR16843.1 - 0.0016 17.8 2.5 0.0016 17.8 2.5 2.7 3 0 0 3 3 3 1 Transmembrane alpha-helix domain Reprolysin_4 PF13583.6 ELR16843.1 - 0.0038 16.9 1.0 0.0099 15.5 1.0 1.6 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_2 PF13574.6 ELR16843.1 - 0.026 14.4 0.2 0.062 13.2 0.2 1.6 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Amidohydro_3 PF07969.11 ELR16844.1 - 6.9e-20 72.0 4.4 1.3e-12 48.0 0.1 2.6 1 1 1 2 2 2 2 Amidohydrolase family Amidohydro_1 PF01979.20 ELR16844.1 - 1.6e-16 60.6 0.5 1.4e-13 50.9 0.1 2.4 2 0 0 2 2 2 2 Amidohydrolase family Pkinase_Tyr PF07714.17 ELR16845.1 - 2.4e-38 131.9 0.1 4.8e-18 65.4 0.0 2.5 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 ELR16845.1 - 1.2e-28 100.3 5.1 3.4e-16 59.4 0.0 2.7 3 0 0 3 3 3 2 Protein kinase domain SH2 PF00017.24 ELR16845.1 - 8.7e-09 35.4 0.0 2.1e-08 34.2 0.0 1.6 1 0 0 1 1 1 1 SH2 domain RNA_pol_Rpc4 PF05132.14 ELR16845.1 - 0.042 14.3 7.7 0.082 13.3 7.7 1.5 1 0 0 1 1 1 0 RNA polymerase III RPC4 Dsh_C PF12316.8 ELR16845.1 - 0.087 13.2 12.2 0.41 11.0 10.9 2.1 2 0 0 2 2 2 0 Segment polarity protein dishevelled (Dsh) C terminal RR_TM4-6 PF06459.12 ELR16845.1 - 7.6 6.3 19.7 13 5.5 19.7 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DAGK_acc PF00609.19 ELR16846.1 - 8.7e-20 71.7 0.2 1.8e-19 70.6 0.0 1.6 2 0 0 2 2 2 1 Diacylglycerol kinase accessory domain DAGK_cat PF00781.24 ELR16846.1 - 9e-20 70.6 0.3 2e-19 69.4 0.0 1.7 2 0 0 2 2 2 1 Diacylglycerol kinase catalytic domain Glyco_transf_28 PF03033.20 ELR16849.1 - 5.9e-08 32.9 0.0 1.3e-07 31.8 0.0 1.6 1 0 0 1 1 1 1 Glycosyltransferase family 28 N-terminal domain RPEL PF02755.15 ELR16849.1 - 0.05 13.3 0.6 0.092 12.5 0.6 1.5 1 0 0 1 1 1 0 RPEL repeat RPA_interact_C PF14768.6 ELR16850.1 - 5.6e-09 36.4 0.1 8.3e-09 35.9 0.1 1.3 1 1 0 1 1 1 1 Replication protein A interacting C-terminal RPA_interact_M PF14767.6 ELR16850.1 - 0.024 15.2 6.8 0.055 14.0 6.8 1.6 1 0 0 1 1 1 0 Replication protein A interacting middle Not1 PF04054.15 ELR16850.1 - 0.076 11.9 0.0 0.078 11.9 0.0 1.0 1 0 0 1 1 1 0 CCR4-Not complex component, Not1 Hydrolase_4 PF12146.8 ELR16851.1 - 8.7e-05 21.9 0.1 0.0061 15.8 0.0 2.8 2 1 1 3 3 3 1 Serine aminopeptidase, S33 UPF0227 PF05728.12 ELR16851.1 - 0.0049 16.8 0.1 0.47 10.4 0.0 2.3 1 1 1 2 2 2 1 Uncharacterised protein family (UPF0227) Abhydrolase_1 PF00561.20 ELR16851.1 - 0.0051 16.5 0.2 0.35 10.5 0.0 2.8 2 1 1 3 3 3 1 alpha/beta hydrolase fold LIP PF03583.14 ELR16851.1 - 0.0065 15.8 0.0 0.0091 15.3 0.0 1.2 1 0 0 1 1 1 1 Secretory lipase Abhydrolase_2 PF02230.16 ELR16851.1 - 0.013 15.3 0.0 0.17 11.6 0.0 2.1 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase Abhydrolase_6 PF12697.7 ELR16851.1 - 0.044 14.4 1.2 0.21 12.2 1.0 1.7 1 1 1 2 2 2 0 Alpha/beta hydrolase family FSH1 PF03959.13 ELR16851.1 - 0.14 11.8 0.0 0.5 10.0 0.0 1.8 2 0 0 2 2 2 0 Serine hydrolase (FSH1) OKR_DC_1 PF01276.20 ELR16852.1 - 2.4e-71 240.7 0.1 3.2e-47 161.2 0.0 2.4 2 1 0 2 2 2 2 Orn/Lys/Arg decarboxylase, major domain OKR_DC_1_C PF03711.15 ELR16852.1 - 4e-05 23.9 0.0 0.00011 22.5 0.0 1.7 1 0 0 1 1 1 1 Orn/Lys/Arg decarboxylase, C-terminal domain Aminotran_1_2 PF00155.21 ELR16852.1 - 0.00062 19.0 0.0 0.0012 18.1 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.21 ELR16852.1 - 0.16 11.2 0.0 0.3 10.3 0.0 1.3 1 0 0 1 1 1 0 Beta-eliminating lyase LNS2 PF08235.13 ELR16853.1 - 3.3e-07 30.0 0.0 1.9e-06 27.5 0.0 1.9 1 1 0 1 1 1 1 LNS2 (Lipin/Ned1/Smp2) Acid_phosphat_B PF03767.14 ELR16853.1 - 0.0024 17.5 0.0 0.0057 16.3 0.0 1.6 1 0 0 1 1 1 1 HAD superfamily, subfamily IIIB (Acid phosphatase) HAD PF12710.7 ELR16853.1 - 0.003 18.0 0.1 0.77 10.1 0.1 2.4 1 1 1 2 2 2 2 haloacid dehalogenase-like hydrolase GNT-I PF03071.15 ELR16854.1 - 2.8e-69 234.0 0.2 5e-69 233.1 0.2 1.4 1 0 0 1 1 1 1 GNT-I family MGAT2 PF05060.14 ELR16854.1 - 1.6e-06 27.5 0.2 0.00044 19.4 0.0 2.3 2 0 0 2 2 2 2 N-acetylglucosaminyltransferase II (MGAT2) Glyco_transf_18 PF15024.6 ELR16854.1 - 4e-06 25.7 3.2 5.4e-06 25.3 3.2 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 18 DNase_II PF03265.15 ELR16855.1 - 3e-99 332.4 0.5 3.3e-99 332.2 0.5 1.0 1 0 0 1 1 1 1 Deoxyribonuclease II SLC3A2_N PF16028.5 ELR16856.1 - 0.082 12.5 0.0 0.13 11.9 0.0 1.4 1 0 0 1 1 1 0 Solute carrier family 3 member 2 N-terminus DNase_II PF03265.15 ELR16857.1 - 4.4e-57 193.8 0.0 5.5e-57 193.5 0.0 1.0 1 0 0 1 1 1 1 Deoxyribonuclease II DNase_II PF03265.15 ELR16858.1 - 2e-97 326.4 0.0 2.3e-97 326.2 0.0 1.0 1 0 0 1 1 1 1 Deoxyribonuclease II OsmC PF02566.19 ELR16859.1 - 3.4e-20 72.4 0.0 5.6e-20 71.7 0.0 1.3 1 0 0 1 1 1 1 OsmC-like protein Tetraspanin PF00335.20 ELR16860.1 - 0.00038 20.2 0.1 0.27 10.9 0.1 2.2 2 0 0 2 2 2 2 Tetraspanin family DUF2371 PF10177.9 ELR16860.1 - 0.018 15.2 0.0 2.3 8.4 0.0 2.2 2 0 0 2 2 2 0 Uncharacterised conserved protein (DUF2371) LapA_dom PF06305.11 ELR16860.1 - 0.044 13.6 2.1 0.54 10.1 0.0 2.7 3 0 0 3 3 3 0 Lipopolysaccharide assembly protein A domain Connexin PF00029.19 ELR16860.1 - 0.069 12.9 0.0 0.15 11.8 0.0 1.4 1 0 0 1 1 1 0 Connexin CaKB PF03185.15 ELR16860.1 - 0.1 12.3 0.0 0.13 11.9 0.0 1.3 1 0 0 1 1 1 0 Calcium-activated potassium channel, beta subunit TraL PF07178.11 ELR16860.1 - 0.15 12.6 0.4 0.54 10.8 0.0 2.0 2 0 0 2 2 2 0 TraL protein Fascin PF06268.13 ELR16861.1 - 1.9e-08 34.5 0.6 2.5e-05 24.4 0.5 2.1 1 1 1 2 2 2 2 Fascin domain FGF PF00167.18 ELR16861.1 - 0.0001 22.4 0.2 0.0089 16.1 0.0 2.0 1 1 1 2 2 2 2 Fibroblast growth factor RicinB_lectin_2 PF14200.6 ELR16861.1 - 0.012 16.3 0.0 0.024 15.4 0.0 1.5 1 1 0 1 1 1 0 Ricin-type beta-trefoil lectin domain-like HATPase_c_2 PF13581.6 ELR16861.1 - 0.057 13.4 0.2 0.13 12.3 0.0 1.7 2 0 0 2 2 2 0 Histidine kinase-like ATPase domain H2TH PF06831.14 ELR16862.1 - 4.1e-09 36.3 0.0 7.1e-09 35.5 0.0 1.4 1 0 0 1 1 1 1 Formamidopyrimidine-DNA glycosylase H2TH domain Fapy_DNA_glyco PF01149.24 ELR16862.1 - 5.2e-06 27.1 0.0 9.1e-06 26.3 0.0 1.4 1 0 0 1 1 1 1 Formamidopyrimidine-DNA glycosylase N-terminal domain Neil1-DNA_bind PF09292.10 ELR16862.1 - 0.00018 21.4 0.1 0.00041 20.3 0.1 1.6 1 0 0 1 1 1 1 Endonuclease VIII-like 1, DNA bind LSM PF01423.22 ELR16863.1 - 9e-16 57.3 0.2 1.2e-15 57.0 0.2 1.1 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 ELR16863.1 - 1.4e-05 25.1 0.0 1.8e-05 24.8 0.0 1.3 1 0 0 1 1 1 1 Ataxin 2 SM domain DUF2642 PF10842.8 ELR16863.1 - 0.14 12.1 0.0 0.25 11.2 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2642) Glyco_hydro_99 PF16317.5 ELR16864.1 - 6e-114 380.7 7.2 7.7e-114 380.4 7.2 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 99 Glyco_tran_WbsX PF14307.6 ELR16864.1 - 2.3e-05 24.0 0.2 4.8e-05 23.0 0.2 1.5 1 0 0 1 1 1 1 Glycosyltransferase WbsX Glyco_hydro_71 PF03659.14 ELR16864.1 - 0.0031 16.4 3.6 0.0048 15.8 3.6 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 71 zf-RING_2 PF13639.6 ELR16865.1 - 9.6e-11 41.8 9.2 9.6e-11 41.8 9.2 3.0 3 0 0 3 3 2 1 Ring finger domain zf-C3HC4_2 PF13923.6 ELR16865.1 - 5.4e-08 32.6 8.7 5.8e-07 29.2 8.3 2.5 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 ELR16865.1 - 3.2e-07 30.5 8.3 2.1e-06 27.9 8.3 2.5 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_3 PF13920.6 ELR16865.1 - 1.8e-06 27.7 6.1 1.8e-06 27.7 6.1 1.9 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 ELR16865.1 - 1.2e-05 25.2 5.7 1.2e-05 25.2 5.7 3.0 4 0 0 4 4 4 1 RING-type zinc-finger zf-C3HC4 PF00097.25 ELR16865.1 - 1.5e-05 24.7 7.8 1.5e-05 24.7 7.8 2.2 3 0 0 3 3 1 1 Zinc finger, C3HC4 type (RING finger) Itfg2 PF15907.5 ELR16865.1 - 0.00091 18.4 0.1 0.0063 15.6 0.2 2.3 2 1 0 2 2 2 1 Integrin-alpha FG-GAP repeat-containing protein 2 Prok-RING_4 PF14447.6 ELR16865.1 - 0.0014 18.4 9.4 0.0063 16.3 6.3 3.0 2 1 0 2 2 2 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 ELR16865.1 - 0.002 18.0 7.0 0.002 18.0 7.0 2.5 3 0 0 3 3 2 1 zinc-RING finger domain zf-RING_11 PF17123.5 ELR16865.1 - 0.0021 17.8 3.7 0.0021 17.8 3.7 2.6 3 0 0 3 3 2 1 RING-like zinc finger zf-UDP PF14569.6 ELR16865.1 - 0.0099 16.0 0.7 0.022 14.8 0.7 1.5 1 0 0 1 1 1 1 Zinc-binding RING-finger zf-ANAPC11 PF12861.7 ELR16865.1 - 0.01 15.9 5.9 0.027 14.5 4.8 2.3 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_4 PF15227.6 ELR16865.1 - 0.037 14.2 12.3 0.11 12.6 5.8 3.6 3 1 0 3 3 3 0 zinc finger of C3HC4-type, RING zf-Nse PF11789.8 ELR16865.1 - 0.055 13.3 2.5 0.15 11.9 2.5 1.7 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit PLATZ PF04640.14 ELR16865.1 - 0.26 11.9 3.2 0.97 10.1 1.9 2.5 2 0 0 2 2 2 0 PLATZ transcription factor zf-RING_4 PF14570.6 ELR16865.1 - 0.42 10.4 5.9 1.4 8.8 5.9 1.9 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain Zn_ribbon_17 PF17120.5 ELR16865.1 - 1.2 8.8 11.5 0.13 11.9 4.8 2.8 3 0 0 3 3 3 0 Zinc-ribbon, C4HC2 type FANCL_C PF11793.8 ELR16865.1 - 6 7.1 12.4 3 8.1 8.0 2.8 2 1 0 2 2 2 0 FANCL C-terminal domain Rad60-SLD PF11976.8 ELR16866.1 - 1.1e-35 121.3 9.3 2.4e-15 56.1 0.8 4.3 4 0 0 4 4 4 3 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.23 ELR16866.1 - 1.6e-15 56.6 0.0 1.7e-05 24.4 0.0 3.4 3 0 0 3 3 3 3 Ubiquitin family dsrm PF00035.26 ELR16866.1 - 0.014 16.1 1.9 36 5.2 0.1 3.5 3 0 0 3 3 3 0 Double-stranded RNA binding motif TPALS PF18178.1 ELR16866.1 - 0.054 12.9 0.0 0.11 11.9 0.0 1.5 1 0 0 1 1 1 0 TIR- and PNP-associating SLOG family SOP4 PF17081.5 ELR16866.1 - 0.061 12.8 0.0 14 5.2 0.0 2.4 2 0 0 2 2 2 0 Suppressor of PMA 1-7 protein PTPRCAP PF15713.5 ELR16866.1 - 0.18 12.1 2.4 0.59 10.4 2.4 1.9 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated Ribosomal_60s PF00428.19 ELR16866.1 - 0.42 11.2 13.6 0.42 11.2 3.4 2.9 2 0 0 2 2 2 0 60s Acidic ribosomal protein RAI1 PF08652.11 ELR16867.1 - 5e-24 84.3 0.0 1.1e-23 83.2 0.0 1.5 1 0 0 1 1 1 1 RAI1 like PD-(D/E)XK nuclease Pkinase_Tyr PF07714.17 ELR16868.1 - 4.3e-46 157.3 0.6 1.6e-44 152.2 0.6 2.5 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ELR16868.1 - 1.5e-35 122.9 0.0 2.7e-34 118.7 0.0 2.1 1 1 0 1 1 1 1 Protein kinase domain SH2 PF00017.24 ELR16868.1 - 4.4e-17 61.9 0.0 1.1e-16 60.7 0.0 1.7 1 0 0 1 1 1 1 SH2 domain Cbl_N2 PF02761.14 ELR16868.1 - 0.0034 18.1 1.1 0.0098 16.6 0.1 2.2 2 1 0 2 2 2 1 CBL proto-oncogene N-terminus, EF hand-like domain cpYpsA PF12694.7 ELR16870.1 - 6.4e-17 61.7 2.6 2.4e-14 53.3 2.6 2.9 1 1 0 1 1 1 1 Circularly permutated YpsA SLOG family STATa_Ig PF18214.1 ELR16871.1 - 2.6e-44 150.2 1.8 4.8e-44 149.3 1.8 1.5 1 0 0 1 1 1 1 STATa Immunoglobulin-like domain EF-hand_12 PF17901.1 ELR16871.1 - 1.3e-23 83.2 2.8 3.9e-18 65.7 0.0 2.9 2 1 1 3 3 3 2 EF-hand fold domain SH2 PF00017.24 ELR16871.1 - 4e-08 33.2 0.0 1.2e-07 31.7 0.0 1.8 1 0 0 1 1 1 1 SH2 domain Dict-STAT-coil PF09267.10 ELR16871.1 - 3.9e-06 27.2 4.8 3.9e-06 27.2 4.8 2.2 3 0 0 3 3 3 1 Dictyostelium STAT, coiled coil Mis12 PF05859.12 ELR16871.1 - 0.048 13.7 0.1 0.048 13.7 0.1 1.6 2 0 0 2 2 2 0 Mis12 protein TrbI PF03743.14 ELR16871.1 - 0.084 12.7 3.3 0.27 11.1 0.0 2.7 2 0 0 2 2 2 0 Bacterial conjugation TrbI-like protein PilJ PF13675.6 ELR16872.1 - 0.017 15.1 1.5 0.017 15.1 1.5 3.3 1 1 2 3 3 3 0 Type IV pili methyl-accepting chemotaxis transducer N-term Prefoldin PF02996.17 ELR16872.1 - 0.76 9.7 9.4 4.6 7.2 0.6 3.2 3 0 0 3 3 3 0 Prefoldin subunit FAP206 PF12018.8 ELR16872.1 - 0.88 9.0 5.4 0.44 10.0 1.3 2.2 2 0 0 2 2 2 0 Domain of unknown function PI3K_P85_iSH2 PF16454.5 ELR16872.1 - 1.5 8.4 12.1 0.3 10.7 1.0 2.8 3 0 0 3 3 3 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain MscS_porin PF12795.7 ELR16872.1 - 6.3 6.3 29.7 0.037 13.6 3.8 3.1 2 1 1 3 3 3 0 Mechanosensitive ion channel porin domain DUF724 PF05266.14 ELR16872.1 - 7.3 6.4 14.6 0.11 12.3 1.1 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF724) Glyco_tranf_2_4 PF13704.6 ELR16873.1 - 0.037 14.6 0.1 0.1 13.1 0.1 1.8 1 0 0 1 1 1 0 Glycosyl transferase family 2 DUF4239 PF14023.6 ELR16874.1 - 4.2 7.0 6.3 11 5.7 6.3 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF4239) PGM_PMM_I PF02878.16 ELR16875.1 - 2.5e-35 121.2 0.2 4.2e-35 120.5 0.2 1.4 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_III PF02880.16 ELR16875.1 - 5e-30 104.0 0.0 9.5e-30 103.1 0.0 1.5 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_II PF02879.16 ELR16875.1 - 3.4e-14 53.3 0.0 1e-13 51.8 0.0 1.9 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_IV PF00408.20 ELR16875.1 - 1.6e-06 28.2 0.0 4.5e-06 26.7 0.0 1.7 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain MMR_HSR1 PF01926.23 ELR16876.1 - 0.00024 21.1 0.1 0.00056 20.0 0.0 1.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase Roc PF08477.13 ELR16876.1 - 0.0011 19.2 0.2 0.0024 18.1 0.2 1.6 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase AAA_16 PF13191.6 ELR16876.1 - 0.005 17.2 0.0 0.0098 16.3 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain AIG1 PF04548.16 ELR16876.1 - 0.011 15.0 0.0 0.019 14.3 0.0 1.3 1 0 0 1 1 1 0 AIG1 family FtsK_SpoIIIE PF01580.18 ELR16876.1 - 0.021 14.2 0.0 0.037 13.4 0.0 1.4 1 0 0 1 1 1 0 FtsK/SpoIIIE family Ploopntkinase3 PF18751.1 ELR16876.1 - 0.026 14.4 0.0 0.045 13.7 0.0 1.3 1 0 0 1 1 1 0 P-loop Nucleotide Kinase3 AAA_29 PF13555.6 ELR16876.1 - 0.043 13.5 0.3 0.22 11.3 0.0 2.2 2 0 0 2 2 2 0 P-loop containing region of AAA domain ABC_tran PF00005.27 ELR16876.1 - 0.05 14.1 0.0 0.1 13.1 0.0 1.5 1 0 0 1 1 1 0 ABC transporter AAA_22 PF13401.6 ELR16876.1 - 0.085 13.1 0.1 0.2 11.9 0.1 1.6 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 ELR16876.1 - 0.13 12.7 0.0 0.24 11.8 0.0 1.5 1 0 0 1 1 1 0 RNA helicase zf-C3HC4_3 PF13920.6 ELR16876.1 - 0.16 11.9 1.6 0.29 11.0 1.6 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Adeno_IVa2 PF02456.15 ELR16876.1 - 0.18 10.5 0.0 0.33 9.7 0.0 1.4 1 0 0 1 1 1 0 Adenovirus IVa2 protein zf-C3HC4_3 PF13920.6 ELR16877.1 - 1.5e-08 34.4 9.8 2.4e-08 33.7 9.8 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 ELR16877.1 - 5.6e-05 22.9 11.5 9.7e-05 22.2 11.5 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 MMR_HSR1 PF01926.23 ELR16877.1 - 0.00012 22.1 0.0 0.00033 20.7 0.0 1.8 2 0 0 2 2 2 1 50S ribosome-binding GTPase zf-RING_5 PF14634.6 ELR16877.1 - 0.00067 19.6 11.8 0.0012 18.7 11.8 1.5 1 0 0 1 1 1 1 zinc-RING finger domain AAA_25 PF13481.6 ELR16877.1 - 0.0013 18.4 1.6 0.0043 16.7 0.3 2.1 2 0 0 2 2 2 1 AAA domain zf-C3HC4 PF00097.25 ELR16877.1 - 0.0018 18.1 13.9 0.0031 17.3 13.9 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 ELR16877.1 - 0.008 16.0 12.9 0.016 15.0 12.9 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 ELR16877.1 - 0.0082 16.4 14.0 0.015 15.6 14.0 1.4 1 0 0 1 1 1 1 Ring finger domain ABC_tran PF00005.27 ELR16877.1 - 0.0099 16.4 0.0 0.016 15.7 0.0 1.3 1 0 0 1 1 1 1 ABC transporter AAA_16 PF13191.6 ELR16877.1 - 0.01 16.2 1.2 0.034 14.5 0.5 2.4 2 2 0 2 2 2 0 AAA ATPase domain DUF815 PF05673.13 ELR16877.1 - 0.018 14.2 0.6 0.17 11.0 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF815) UPF0547 PF10571.9 ELR16877.1 - 0.065 13.3 3.3 0.16 12.1 3.3 1.7 1 0 0 1 1 1 0 Uncharacterised protein family UPF0547 IIGP PF05049.13 ELR16877.1 - 0.081 12.0 0.0 0.12 11.5 0.0 1.1 1 0 0 1 1 1 0 Interferon-inducible GTPase (IIGP) GxGYxYP_C PF14323.6 ELR16877.1 - 0.11 12.3 0.0 0.16 11.8 0.0 1.2 1 0 0 1 1 1 0 GxGYxYP putative glycoside hydrolase C-terminal domain Dynamin_N PF00350.23 ELR16877.1 - 0.17 11.9 0.8 9.8 6.2 0.2 2.4 1 1 1 2 2 2 0 Dynamin family HK_sensor PF16750.5 ELR16877.1 - 0.18 12.1 0.2 0.38 11.1 0.0 1.7 2 0 0 2 2 1 0 Sensor domain of 2-component histidine kinase AAA_28 PF13521.6 ELR16877.1 - 0.23 11.7 1.4 0.62 10.3 0.7 2.0 1 1 1 2 2 2 0 AAA domain zf-RING_10 PF16685.5 ELR16877.1 - 0.78 9.9 9.0 1.5 9.0 9.0 1.4 1 0 0 1 1 1 0 zinc RING finger of MSL2 zf-RING_4 PF14570.6 ELR16877.1 - 4.1 7.3 10.2 8.3 6.3 10.2 1.5 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain GDP_Man_Dehyd PF16363.5 ELR16878.1 - 1.4e-52 179.2 0.0 3.4e-52 177.9 0.0 1.6 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 ELR16878.1 - 7.3e-47 159.8 0.0 1.1e-46 159.2 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 ELR16878.1 - 1.6e-12 47.0 0.0 2.4e-12 46.4 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Polysacc_synt_2 PF02719.15 ELR16878.1 - 2.3e-08 33.5 0.0 3.6e-07 29.6 0.0 2.0 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein NAD_binding_4 PF07993.12 ELR16878.1 - 4.2e-06 26.1 0.4 9.4e-05 21.7 0.0 2.2 2 0 0 2 2 2 1 Male sterility protein KR PF08659.10 ELR16878.1 - 9.4e-05 22.4 0.3 0.00028 20.9 0.3 1.7 1 1 0 1 1 1 1 KR domain adh_short PF00106.25 ELR16878.1 - 0.00089 18.8 0.0 0.0045 16.5 0.0 2.0 1 1 0 1 1 1 1 short chain dehydrogenase UPF0489 PF12640.7 ELR16879.1 - 0.015 15.6 0.0 0.018 15.3 0.0 1.2 1 0 0 1 1 1 0 UPF0489 domain AA_permease_2 PF13520.6 ELR16880.1 - 4.6e-46 157.5 42.4 4.6e-46 157.5 42.4 1.5 2 0 0 2 2 2 1 Amino acid permease AA_permease PF00324.21 ELR16880.1 - 4.8e-36 124.4 34.7 8.6e-36 123.5 34.7 1.4 1 0 0 1 1 1 1 Amino acid permease AA_permease_C PF13906.6 ELR16880.1 - 1.7e-18 66.4 4.8 1.7e-18 66.4 4.8 2.8 2 0 0 2 2 2 1 C-terminus of AA_permease Spore_permease PF03845.13 ELR16880.1 - 0.00073 18.5 10.7 0.00073 18.5 10.7 2.5 2 1 0 2 2 2 1 Spore germination protein PT-VENN PF04829.13 ELR16880.1 - 0.63 10.2 5.1 43 4.3 0.1 4.1 3 0 0 3 3 3 0 Pre-toxin domain with VENN motif Transthyretin PF00576.21 ELR16881.1 - 1.7e-33 115.6 0.0 2.8e-33 114.9 0.0 1.3 1 0 0 1 1 1 1 HIUase/Transthyretin family F-box-like PF12937.7 ELR16882.1 - 1.2e-09 37.9 1.6 2.4e-09 36.9 1.6 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ELR16882.1 - 1.6e-05 24.7 0.5 3e-05 23.8 0.5 1.3 1 0 0 1 1 1 1 F-box domain Ras PF00071.22 ELR16882.1 - 0.00062 19.4 0.0 0.0015 18.1 0.0 1.6 1 1 0 1 1 1 1 Ras family Roc PF08477.13 ELR16882.1 - 0.0029 17.8 0.0 0.0047 17.1 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase AAA_7 PF12775.7 ELR16882.1 - 0.01 15.4 0.0 0.014 14.9 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_16 PF13191.6 ELR16882.1 - 0.036 14.5 0.0 0.054 13.9 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain NACHT PF05729.12 ELR16882.1 - 0.06 13.3 0.0 0.085 12.8 0.0 1.4 1 0 0 1 1 1 0 NACHT domain AAA_22 PF13401.6 ELR16882.1 - 0.08 13.2 0.1 0.22 11.8 0.1 1.8 2 0 0 2 2 2 0 AAA domain RsgA_GTPase PF03193.16 ELR16882.1 - 0.18 11.7 0.0 0.25 11.2 0.0 1.3 1 0 0 1 1 1 0 RsgA GTPase MMR_HSR1 PF01926.23 ELR16883.1 - 3.3e-07 30.4 0.0 5e-07 29.8 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase IIGP PF05049.13 ELR16883.1 - 0.00045 19.4 0.0 0.00065 18.9 0.0 1.2 1 0 0 1 1 1 1 Interferon-inducible GTPase (IIGP) AAA_16 PF13191.6 ELR16883.1 - 0.0026 18.2 0.3 0.0083 16.5 0.1 2.0 1 1 1 2 2 2 1 AAA ATPase domain Dynamin_N PF00350.23 ELR16883.1 - 0.0049 17.0 0.1 0.012 15.7 0.1 1.6 2 0 0 2 2 2 1 Dynamin family ABC_tran PF00005.27 ELR16883.1 - 0.0072 16.8 0.0 0.012 16.1 0.0 1.4 1 0 0 1 1 1 1 ABC transporter DUF815 PF05673.13 ELR16883.1 - 0.011 14.9 0.0 0.023 13.9 0.0 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF815) FtsK_SpoIIIE PF01580.18 ELR16883.1 - 0.027 13.8 0.0 0.05 12.9 0.0 1.3 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_28 PF13521.6 ELR16883.1 - 0.042 14.1 3.0 0.12 12.6 0.5 2.2 1 1 1 2 2 2 0 AAA domain IstB_IS21 PF01695.17 ELR16883.1 - 0.11 12.3 0.7 0.51 10.1 0.0 2.3 3 0 0 3 3 3 0 IstB-like ATP binding protein RsgA_GTPase PF03193.16 ELR16883.1 - 0.11 12.4 0.0 1.4 8.8 0.0 2.0 2 0 0 2 2 2 0 RsgA GTPase IF-2 PF11987.8 ELR16883.1 - 0.11 12.6 0.0 0.27 11.4 0.0 1.6 2 0 0 2 2 2 0 Translation-initiation factor 2 GTP_EFTU PF00009.27 ELR16883.1 - 0.13 11.8 0.0 6.3 6.3 0.0 2.1 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain AAA_24 PF13479.6 ELR16883.1 - 0.15 11.8 0.0 0.37 10.5 0.0 1.7 2 0 0 2 2 2 0 AAA domain AAA_22 PF13401.6 ELR16883.1 - 0.16 12.2 0.1 0.42 10.9 0.1 1.6 2 0 0 2 2 2 0 AAA domain AAA_7 PF12775.7 ELR16883.1 - 0.16 11.4 0.0 0.25 10.8 0.0 1.2 1 0 0 1 1 1 0 P-loop containing dynein motor region FeoB_N PF02421.18 ELR16883.1 - 0.2 11.2 0.1 0.42 10.1 0.1 1.7 1 1 0 1 1 1 0 Ferrous iron transport protein B AA_permease_C PF13906.6 ELR16884.1 - 1.1e-19 70.3 4.8 1.4e-19 69.9 4.8 1.2 1 0 0 1 1 1 1 C-terminus of AA_permease Ras PF00071.22 ELR16886.1 - 2.1e-09 37.2 0.0 2.8e-09 36.8 0.0 1.1 1 0 0 1 1 1 1 Ras family NUDIX_2 PF13869.6 ELR16887.1 - 1.2e-84 282.6 0.1 1.4e-84 282.4 0.1 1.0 1 0 0 1 1 1 1 Nucleotide hydrolase NUDIX PF00293.28 ELR16887.1 - 0.026 14.6 0.0 0.041 13.9 0.0 1.3 1 0 0 1 1 1 0 NUDIX domain FG-GAP PF01839.23 ELR16889.1 - 2.5e-23 81.9 46.5 2.1e-05 24.5 1.3 6.2 6 0 0 6 6 6 5 FG-GAP repeat VCBS PF13517.6 ELR16889.1 - 5.6e-11 42.9 30.1 0.00018 22.0 5.5 5.7 3 2 2 5 5 5 5 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella TcdB_toxin_midN PF12256.8 ELR16889.1 - 0.013 14.9 11.9 1.5 8.2 0.1 4.9 3 2 2 5 5 5 0 Insecticide toxin TcdB middle/N-terminal region FG-GAP PF01839.23 ELR16890.1 - 9.7e-06 25.6 1.9 1.8e-05 24.7 1.9 1.5 1 0 0 1 1 1 1 FG-GAP repeat VCBS PF13517.6 ELR16890.1 - 0.00015 22.2 0.4 0.00015 22.2 0.4 1.6 2 0 0 2 2 1 1 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella SURF2 PF05477.11 ELR16890.1 - 0.068 12.8 7.7 0.077 12.7 7.7 1.1 1 0 0 1 1 1 0 Surfeit locus protein 2 (SURF2) PPP4R2 PF09184.11 ELR16890.1 - 0.11 12.1 10.6 0.13 11.9 10.6 1.1 1 0 0 1 1 1 0 PPP4R2 NOA36 PF06524.12 ELR16890.1 - 0.19 11.0 16.9 0.21 10.9 16.9 1.1 1 0 0 1 1 1 0 NOA36 protein BUD22 PF09073.10 ELR16890.1 - 0.19 11.0 10.6 0.21 10.9 10.6 1.0 1 0 0 1 1 1 0 BUD22 Radial_spoke PF04712.12 ELR16890.1 - 0.22 10.4 5.8 0.22 10.4 5.8 1.1 1 0 0 1 1 1 0 Radial spokehead-like protein SDA1 PF05285.12 ELR16890.1 - 0.28 10.5 14.2 0.31 10.4 14.2 1.1 1 0 0 1 1 1 0 SDA1 Astro_capsid_p PF12226.8 ELR16890.1 - 0.34 10.0 7.9 0.35 10.0 7.9 1.2 1 0 0 1 1 1 0 Turkey astrovirus capsid protein Sigma70_ner PF04546.13 ELR16890.1 - 0.61 9.9 11.1 0.65 9.8 11.1 1.1 1 0 0 1 1 1 0 Sigma-70, non-essential region Nop14 PF04147.12 ELR16890.1 - 0.63 8.2 16.7 0.68 8.1 16.7 1.0 1 0 0 1 1 1 0 Nop14-like family CDC45 PF02724.14 ELR16890.1 - 0.64 8.2 12.9 0.72 8.1 12.9 1.1 1 0 0 1 1 1 0 CDC45-like protein FAM176 PF14851.6 ELR16890.1 - 2.9 7.5 9.8 5.1 6.8 9.8 1.4 1 0 0 1 1 1 0 FAM176 family TFB6 PF17110.5 ELR16890.1 - 5 6.8 8.3 6.4 6.5 8.3 1.2 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH DUF3464 PF11947.8 ELR16890.1 - 5.4 6.8 5.2 9.6 5.9 0.0 2.1 2 0 0 2 2 2 0 Photosynthesis affected mutant 68 DUF4637 PF15470.6 ELR16890.1 - 6.1 6.6 12.6 8.7 6.0 12.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) Roughex PF06020.11 ELR16890.1 - 7.8 5.5 9.2 8.1 5.4 9.2 1.2 1 0 0 1 1 1 0 Drosophila roughex protein Mito_carr PF00153.27 ELR16895.1 - 6.6e-46 154.2 4.2 2.3e-19 69.1 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 ELR16895.1 - 0.011 15.0 5.2 0.13 11.4 1.4 2.4 1 1 1 2 2 2 0 Gammaproteobacterial serine protease Trp_oprn_chp PF09534.10 ELR16895.1 - 9.3 6.0 10.7 0.67 9.7 2.5 2.3 2 1 1 3 3 3 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) Pkinase_Tyr PF07714.17 ELR16896.1 - 3.4e-50 170.7 0.0 4.7e-50 170.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ELR16896.1 - 2.1e-41 142.1 0.0 3e-41 141.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain SH2 PF00017.24 ELR16896.1 - 5.6e-11 42.4 0.0 1.8e-10 40.7 0.0 2.0 2 0 0 2 2 2 1 SH2 domain APH PF01636.23 ELR16896.1 - 0.00061 19.8 0.0 0.0052 16.7 0.0 2.3 2 0 0 2 2 2 1 Phosphotransferase enzyme family Cbl_N2 PF02761.14 ELR16896.1 - 0.11 13.2 0.1 0.26 12.0 0.1 1.6 1 0 0 1 1 1 0 CBL proto-oncogene N-terminus, EF hand-like domain CH PF00307.31 ELR16897.1 - 1.4e-06 28.4 0.0 2.3e-06 27.8 0.0 1.3 1 0 0 1 1 1 1 Calponin homology (CH) domain DASH_Dad4 PF08650.10 ELR16897.1 - 0.046 13.7 0.2 0.12 12.4 0.2 1.7 1 1 0 1 1 1 0 DASH complex subunit Dad4 Csm1_N PF18504.1 ELR16898.1 - 0.0015 18.8 0.8 0.0015 18.8 0.8 1.7 2 0 0 2 2 2 1 Csm1 N-terminal domain DUF2205 PF10224.9 ELR16898.1 - 0.031 14.3 1.7 0.053 13.5 1.7 1.4 1 0 0 1 1 1 0 Short coiled-coil protein DUF883 PF05957.13 ELR16898.1 - 0.067 13.8 0.8 0.11 13.2 0.8 1.3 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF883) Mto2_bdg PF12808.7 ELR16898.1 - 0.2 12.0 6.9 12 6.3 6.9 2.4 1 1 0 1 1 1 0 Micro-tubular organiser Mto1 C-term Mto2-binding region DUF3847 PF12958.7 ELR16898.1 - 2.2 8.4 8.2 0.1 12.8 3.0 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3847) Pkinase_Tyr PF07714.17 ELR16899.1 - 9.1e-51 172.6 0.0 1.1e-50 172.4 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ELR16899.1 - 5.4e-42 144.0 0.0 7e-42 143.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.23 ELR16899.1 - 0.00032 20.7 0.0 0.0022 18.0 0.0 2.1 2 0 0 2 2 2 1 Phosphotransferase enzyme family Cbl_N2 PF02761.14 ELR16899.1 - 0.045 14.5 0.2 0.1 13.3 0.2 1.5 1 0 0 1 1 1 0 CBL proto-oncogene N-terminus, EF hand-like domain CH PF00307.31 ELR16900.1 - 2.4e-12 47.0 0.0 5.3e-12 45.9 0.0 1.6 1 0 0 1 1 1 1 Calponin homology (CH) domain HAUS6_N PF14661.6 ELR16900.1 - 0.022 14.4 4.2 0.045 13.3 4.2 1.5 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus LUC7 PF03194.15 ELR16900.1 - 0.096 12.3 10.8 0.67 9.6 9.3 2.0 2 0 0 2 2 2 0 LUC7 N_terminus GBP_C PF02841.14 ELR16900.1 - 0.21 11.0 14.7 0.4 10.0 14.7 1.4 1 0 0 1 1 1 0 Guanylate-binding protein, C-terminal domain Caldesmon PF02029.15 ELR16900.1 - 0.27 10.0 20.2 0.44 9.2 20.2 1.3 1 0 0 1 1 1 0 Caldesmon FapA PF03961.13 ELR16900.1 - 0.64 8.6 6.7 1 7.9 6.7 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A DUF3987 PF13148.6 ELR16900.1 - 0.73 8.8 12.6 1.2 8.0 12.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3987) AAA_13 PF13166.6 ELR16900.1 - 1 7.9 10.4 1.6 7.3 10.4 1.2 1 0 0 1 1 1 0 AAA domain LCD1 PF09798.9 ELR16900.1 - 1.7 7.1 8.7 3.1 6.2 8.6 1.4 1 1 0 1 1 1 0 DNA damage checkpoint protein APG6_N PF17675.1 ELR16900.1 - 2.6 8.6 24.5 0.58 10.7 18.8 2.2 2 0 0 2 2 2 0 Apg6 coiled-coil region CPSF73-100_C PF11718.8 ELR16901.1 - 6.4e-48 163.2 2.1 2.1e-47 161.5 2.1 1.8 1 1 0 1 1 1 1 Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term Beta-Casp PF10996.8 ELR16901.1 - 5e-34 116.9 0.0 1e-33 115.9 0.0 1.6 1 0 0 1 1 1 1 Beta-Casp domain RMMBL PF07521.12 ELR16901.1 - 3.5e-16 58.9 0.0 9e-16 57.6 0.0 1.8 1 0 0 1 1 1 1 Zn-dependent metallo-hydrolase RNA specificity domain Lactamase_B_6 PF16661.5 ELR16901.1 - 1.1e-09 38.0 0.0 2.7e-09 36.7 0.0 1.6 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily domain Beta_lactamase3 PF17030.5 ELR16901.1 - 0.0049 16.1 0.0 0.0086 15.3 0.0 1.4 1 0 0 1 1 1 1 Putative beta-lactamase-like family Lactamase_B PF00753.27 ELR16901.1 - 0.097 12.7 0.0 0.19 11.7 0.0 1.5 1 0 0 1 1 1 0 Metallo-beta-lactamase superfamily Lactamase_B PF00753.27 ELR16902.1 - 1.6e-11 44.6 0.1 2e-11 44.3 0.1 1.1 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_6 PF16661.5 ELR16902.1 - 4.6e-08 32.7 0.0 2.8e-07 30.1 0.0 1.8 2 0 0 2 2 2 1 Metallo-beta-lactamase superfamily domain Lactamase_B_2 PF12706.7 ELR16902.1 - 1.4e-05 24.7 0.2 1.6e-05 24.5 0.2 1.1 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 ELR16902.1 - 0.00011 22.1 0.0 0.00015 21.7 0.0 1.2 1 0 0 1 1 1 1 Beta-lactamase superfamily domain MMR_HSR1 PF01926.23 ELR16903.1 - 4.5e-11 42.8 0.0 9.3e-11 41.8 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase zf-RING_UBOX PF13445.6 ELR16903.1 - 3.5e-10 39.7 4.6 3.6e-10 39.7 3.1 1.9 1 1 0 1 1 1 1 RING-type zinc-finger AIG1 PF04548.16 ELR16903.1 - 2.1e-09 37.0 0.0 3.1e-09 36.5 0.0 1.3 1 0 0 1 1 1 1 AIG1 family zf-C3HC4_2 PF13923.6 ELR16903.1 - 5.6e-08 32.5 2.3 5.6e-08 32.5 2.3 2.2 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 ELR16903.1 - 7.3e-08 32.6 6.2 1.9e-07 31.3 6.2 1.7 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 ELR16903.1 - 9.8e-08 31.7 4.7 2.6e-07 30.4 4.7 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ELR16903.1 - 2.3e-07 30.7 4.0 2.3e-07 30.7 4.0 1.8 2 0 0 2 2 2 1 zinc-RING finger domain RsgA_GTPase PF03193.16 ELR16903.1 - 5e-07 29.8 0.0 3.1e-06 27.2 0.0 2.1 2 0 0 2 2 2 1 RsgA GTPase Dynamin_N PF00350.23 ELR16903.1 - 5.1e-06 26.6 0.0 0.016 15.3 0.0 2.5 1 1 1 2 2 2 2 Dynamin family zf-C3HC4_3 PF13920.6 ELR16903.1 - 1e-05 25.3 8.3 0.00012 21.8 6.8 2.9 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 ELR16903.1 - 3.3e-05 23.9 5.7 9e-05 22.5 5.7 1.8 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING FeoB_N PF02421.18 ELR16903.1 - 0.0012 18.4 0.0 0.0033 17.0 0.0 1.7 2 0 0 2 2 2 1 Ferrous iron transport protein B zf-Nse PF11789.8 ELR16903.1 - 0.0032 17.2 1.1 0.0071 16.1 1.1 1.6 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit ABC_tran PF00005.27 ELR16903.1 - 0.0073 16.8 0.0 0.018 15.5 0.0 1.7 1 0 0 1 1 1 1 ABC transporter zf-RING_11 PF17123.5 ELR16903.1 - 0.0083 15.8 1.9 0.021 14.6 1.9 1.7 1 0 0 1 1 1 1 RING-like zinc finger Prok-RING_4 PF14447.6 ELR16903.1 - 0.01 15.7 6.2 0.66 9.9 6.7 3.0 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 AAA_16 PF13191.6 ELR16903.1 - 0.02 15.3 0.0 0.1 12.9 0.0 2.1 2 0 0 2 2 2 0 AAA ATPase domain zf-MIZ PF02891.20 ELR16903.1 - 0.022 14.5 3.8 0.048 13.4 3.8 1.6 1 0 0 1 1 1 0 MIZ/SP-RING zinc finger Septin PF00735.18 ELR16903.1 - 0.048 12.9 0.0 0.11 11.7 0.0 1.6 2 0 0 2 2 2 0 Septin IBR PF01485.21 ELR16903.1 - 0.071 13.4 2.8 0.08 13.2 0.9 2.1 2 0 0 2 2 1 0 IBR domain, a half RING-finger domain SRPRB PF09439.10 ELR16903.1 - 0.13 11.7 0.0 0.25 10.7 0.0 1.4 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit zf-RING_4 PF14570.6 ELR16903.1 - 0.53 10.1 4.6 2 8.3 4.6 2.0 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-dskA_traR PF01258.17 ELR16903.1 - 2.1 8.3 6.0 1.1 9.3 3.2 2.0 2 0 0 2 2 1 0 Prokaryotic dksA/traR C4-type zinc finger FYVE PF01363.21 ELR16903.1 - 3.1 8.0 7.7 1.1 9.4 3.0 2.4 2 0 0 2 2 2 0 FYVE zinc finger zf-RING_6 PF14835.6 ELR16903.1 - 4.2 7.3 6.0 2 8.4 2.9 2.1 2 1 0 2 2 2 0 zf-RING of BARD1-type protein CLU PF13236.6 ELR16904.1 - 1.5e-43 149.2 0.0 4.2e-43 147.7 0.0 1.8 1 0 0 1 1 1 1 Clustered mitochondria eIF3_p135 PF12807.7 ELR16904.1 - 0.00057 20.0 31.7 0.015 15.4 27.6 3.9 2 1 1 3 3 3 1 Translation initiation factor eIF3 subunit 135 Ank_5 PF13857.6 ELR16905.1 - 2.9e-23 81.6 5.2 3.1e-09 36.9 1.1 3.2 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_4 PF13637.6 ELR16905.1 - 1.5e-17 63.7 0.1 5e-08 33.3 0.0 2.4 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 ELR16905.1 - 1.6e-17 63.9 0.0 3.3e-17 62.8 0.0 1.6 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.30 ELR16905.1 - 1.4e-15 56.9 2.2 6e-06 26.5 0.3 3.4 3 0 0 3 3 3 2 Ankyrin repeat Ank_3 PF13606.6 ELR16905.1 - 5.1e-14 51.0 0.1 3e-05 24.1 0.1 3.4 3 0 0 3 3 3 2 Ankyrin repeat QIL1 PF15884.5 ELR16905.1 - 0.051 14.2 0.0 0.1 13.2 0.0 1.4 1 0 0 1 1 1 0 MICOS complex subunit MIC13, QIL1 Endosulfine PF04667.17 ELR16906.1 - 1.5e-06 28.2 0.2 1.7e-06 28.1 0.2 1.1 1 0 0 1 1 1 1 cAMP-regulated phosphoprotein/endosulfine conserved region TPR_2 PF07719.17 ELR16907.1 - 1.2e-18 65.7 8.7 5.1e-09 35.6 0.1 5.1 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_8 PF13181.6 ELR16907.1 - 6.2e-15 54.1 1.1 2.4e-08 33.5 0.0 4.3 5 0 0 5 5 4 2 Tetratricopeptide repeat TPR_14 PF13428.6 ELR16907.1 - 6.9e-15 54.5 18.0 0.00072 20.2 0.0 5.8 2 1 3 6 6 5 4 Tetratricopeptide repeat TPR_16 PF13432.6 ELR16907.1 - 7.1e-15 55.4 10.2 7.7e-06 26.5 0.1 3.7 2 2 2 4 4 4 4 Tetratricopeptide repeat TPR_19 PF14559.6 ELR16907.1 - 1e-14 54.8 8.0 6.6e-07 29.8 0.2 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_1 PF00515.28 ELR16907.1 - 5.3e-13 48.2 6.3 6.7e-10 38.4 0.1 4.8 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_12 PF13424.6 ELR16907.1 - 9.6e-11 41.8 13.1 0.00048 20.4 0.0 4.4 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_7 PF13176.6 ELR16907.1 - 4e-10 39.0 4.1 5.3e-06 26.1 0.1 4.1 4 0 0 4 4 3 2 Tetratricopeptide repeat TPR_11 PF13414.6 ELR16907.1 - 3.7e-09 36.1 5.2 4e-06 26.4 1.2 3.9 3 1 1 4 4 4 1 TPR repeat TPR_9 PF13371.6 ELR16907.1 - 7.3e-08 32.5 6.9 1.3e-06 28.5 0.2 3.5 1 1 1 3 3 3 1 Tetratricopeptide repeat TPR_6 PF13174.6 ELR16907.1 - 4.7e-07 30.0 5.6 0.072 13.8 0.0 5.2 5 0 0 5 5 5 1 Tetratricopeptide repeat ANAPC3 PF12895.7 ELR16907.1 - 1.4e-05 25.2 2.0 0.05 13.8 0.1 3.6 3 1 0 3 3 3 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_10 PF13374.6 ELR16907.1 - 2e-05 24.3 14.1 0.037 13.9 0.2 4.8 4 1 1 5 5 5 2 Tetratricopeptide repeat TPR_15 PF13429.6 ELR16907.1 - 0.00013 21.3 3.5 0.0026 17.0 0.1 2.5 1 1 2 3 3 3 2 Tetratricopeptide repeat TPR_17 PF13431.6 ELR16907.1 - 0.0006 20.0 3.5 0.19 12.2 0.0 3.9 5 0 0 5 5 3 1 Tetratricopeptide repeat TPR_3 PF07720.12 ELR16907.1 - 0.0055 16.7 0.1 0.027 14.5 0.0 2.3 2 0 0 2 2 2 1 Tetratricopeptide repeat Coatomer_E PF04733.14 ELR16907.1 - 0.0069 15.8 0.1 0.012 15.0 0.1 1.3 1 0 0 1 1 1 1 Coatomer epsilon subunit YfdX PF10938.8 ELR16907.1 - 0.0081 16.1 0.2 0.58 10.1 0.0 3.0 3 0 0 3 3 3 1 YfdX protein SNAP PF14938.6 ELR16907.1 - 0.017 14.5 0.8 1.2 8.5 0.4 2.2 1 1 1 2 2 2 0 Soluble NSF attachment protein, SNAP Fis1_TPR_C PF14853.6 ELR16907.1 - 0.024 14.7 0.5 15 5.7 0.0 3.0 4 0 0 4 4 3 0 Fis1 C-terminal tetratricopeptide repeat MIT PF04212.18 ELR16907.1 - 0.066 13.3 4.0 2.5 8.3 0.2 3.4 3 0 0 3 3 3 0 MIT (microtubule interacting and transport) domain CysG_dimeriser PF10414.9 ELR16907.1 - 8.6 6.2 6.7 14 5.5 0.1 3.5 4 0 0 4 4 4 0 Sirohaem synthase dimerisation region TspO_MBR PF03073.15 ELR16908.1 - 2.2e-50 170.2 7.5 2.5e-50 170.0 7.5 1.0 1 0 0 1 1 1 1 TspO/MBR family ACBP PF00887.19 ELR16909.1 - 2.6e-27 94.9 0.9 3.7e-27 94.3 0.9 1.3 1 0 0 1 1 1 1 Acyl CoA binding protein FERM_M PF00373.18 ELR16909.1 - 0.11 12.9 0.2 0.25 11.7 0.2 1.6 1 1 0 1 1 1 0 FERM central domain GFO_IDH_MocA PF01408.22 ELR16911.1 - 1.3e-19 71.1 0.0 2.9e-19 70.0 0.0 1.6 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.17 ELR16911.1 - 3e-07 30.5 0.0 6.4e-07 29.4 0.0 1.6 1 0 0 1 1 1 1 Oxidoreductase family, C-terminal alpha/beta domain GAS PF13851.6 ELR16912.1 - 0.013 14.8 0.9 0.013 14.8 0.9 2.6 2 1 0 2 2 2 0 Growth-arrest specific micro-tubule binding RecQ_Zn_bind PF16124.5 ELR16912.1 - 0.56 11.0 0.1 0.56 11.0 0.1 3.4 3 1 0 3 3 3 0 RecQ zinc-binding ATG16 PF08614.11 ELR16912.1 - 0.67 10.1 33.2 0.43 10.8 16.5 2.7 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) FAA_hydro_N_2 PF18288.1 ELR16912.1 - 1.6 9.2 4.8 1.4 9.4 1.4 2.4 2 0 0 2 2 2 0 Fumarylacetoacetase N-terminal domain 2 T7SS_ESX_EspC PF10824.8 ELR16912.1 - 3.6 8.1 9.0 40 4.8 0.4 3.6 3 0 0 3 3 3 0 Excreted virulence factor EspC, type VII ESX diderm RCC1 PF00415.18 ELR16913.1 - 7.7e-27 93.7 4.0 1.8e-10 41.3 0.0 4.1 3 1 1 4 4 4 3 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 ELR16913.1 - 1.2e-17 63.2 5.7 3.5e-09 36.2 0.6 3.5 3 0 0 3 3 3 3 Regulator of chromosome condensation (RCC1) repeat ubiquitin PF00240.23 ELR16914.1 - 3.1e-19 68.5 0.3 4.9e-14 51.8 0.0 2.8 3 0 0 3 3 3 2 Ubiquitin family Rad60-SLD PF11976.8 ELR16914.1 - 1.6e-05 24.7 0.0 0.00039 20.2 0.0 2.3 2 0 0 2 2 2 1 Ubiquitin-2 like Rad60 SUMO-like zf-Sec23_Sec24 PF04810.15 ELR16914.1 - 0.082 13.0 2.1 0.15 12.1 2.1 1.4 1 0 0 1 1 1 0 Sec23/Sec24 zinc finger Tash_PEST PF07708.11 ELR16914.1 - 0.26 11.5 1.6 0.58 10.4 1.6 1.6 1 0 0 1 1 1 0 Tash protein PEST motif zf-RanBP PF00641.18 ELR16914.1 - 0.38 10.1 7.3 0.63 9.4 7.3 1.3 1 0 0 1 1 1 0 Zn-finger in Ran binding protein and others AMP-binding PF00501.28 ELR16915.1 - 3.8e-103 345.3 0.0 5.9e-103 344.7 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme ThrE PF06738.12 ELR16917.1 - 5.6e-63 212.5 17.5 5.4e-55 186.4 1.1 2.2 2 0 0 2 2 2 2 Putative threonine/serine exporter ThrE_2 PF12821.7 ELR16917.1 - 4.8e-18 65.5 21.1 2.4e-14 53.6 7.1 2.2 2 0 0 2 2 2 2 Threonine/Serine exporter, ThrE CCSAP PF15748.5 ELR16917.1 - 0.0031 17.7 13.5 0.0031 17.7 13.5 2.3 2 0 0 2 2 2 1 Centriole, cilia and spindle-associated DUF2627 PF11118.8 ELR16917.1 - 0.014 15.9 1.1 0.053 14.1 1.1 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2627) NARP1 PF12569.8 ELR16917.1 - 2.5 6.9 13.0 4.4 6.1 13.0 1.3 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 GST_C_3 PF14497.6 ELR16918.1 - 8.9e-21 73.9 0.0 1.4e-20 73.4 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 ELR16918.1 - 1.9e-11 44.1 0.0 3.7e-11 43.2 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 ELR16918.1 - 2.3e-10 40.6 0.0 5.2e-10 39.4 0.0 1.7 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 ELR16918.1 - 8.5e-05 22.5 0.0 0.00017 21.6 0.0 1.6 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 ELR16918.1 - 0.0012 19.2 0.0 0.0024 18.2 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain adh_short PF00106.25 ELR16919.1 - 1.1e-07 31.6 0.1 4.8e-06 26.2 0.1 2.8 2 1 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.6 ELR16919.1 - 1.6e-05 24.6 0.0 0.012 15.2 0.0 2.4 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase Rieske_2 PF13806.6 ELR16920.1 - 9.1e-06 25.6 0.0 2.5e-05 24.1 0.0 1.7 1 1 0 1 1 1 1 Rieske-like [2Fe-2S] domain Rieske PF00355.26 ELR16920.1 - 0.0037 17.2 0.1 0.0065 16.4 0.1 1.6 1 1 0 1 1 1 1 Rieske [2Fe-2S] domain DUF2057 PF09829.9 ELR16920.1 - 0.023 14.9 0.9 5.5 7.1 0.6 2.1 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2057) CCDC53 PF10152.9 ELR16920.1 - 0.54 10.7 2.6 0.81 10.1 2.6 1.4 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex ubiquitin PF00240.23 ELR16921.1 - 1.7e-15 56.5 0.0 3e-12 46.1 0.0 3.2 3 0 0 3 3 3 2 Ubiquitin family Ubiquitin_2 PF14560.6 ELR16921.1 - 0.0049 17.3 0.0 0.025 15.0 0.0 2.0 2 0 0 2 2 2 1 Ubiquitin-like domain zf-RanBP PF00641.18 ELR16921.1 - 0.018 14.3 3.1 0.03 13.7 3.1 1.3 1 0 0 1 1 1 0 Zn-finger in Ran binding protein and others Rad60-SLD PF11976.8 ELR16921.1 - 0.03 14.2 0.0 0.18 11.6 0.0 2.2 3 0 0 3 3 3 0 Ubiquitin-2 like Rad60 SUMO-like F-actin_cap_A PF01267.17 ELR16924.1 - 6.9e-81 271.6 0.0 7.8e-81 271.4 0.0 1.0 1 0 0 1 1 1 1 F-actin capping protein alpha subunit RhoGAP PF00620.27 ELR16925.1 - 1.9e-35 122.0 0.1 4.2e-35 120.8 0.1 1.6 1 0 0 1 1 1 1 RhoGAP domain RhoGEF PF00621.20 ELR16925.1 - 0.00017 21.9 2.6 0.00088 19.6 0.0 2.8 2 2 0 2 2 2 1 RhoGEF domain IQ_SEC7_PH PF16453.5 ELR16925.1 - 0.0015 18.5 0.0 0.0035 17.3 0.0 1.6 1 0 0 1 1 1 1 PH domain PH_13 PF16652.5 ELR16925.1 - 0.088 12.6 0.4 7.6 6.3 0.1 2.5 1 1 1 2 2 2 0 Pleckstrin homology domain Abhydrolase_1 PF00561.20 ELR16926.1 - 6.1e-29 101.4 0.2 2.3e-26 93.0 0.5 2.1 1 1 1 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 ELR16926.1 - 4.8e-18 66.6 5.7 5.9e-18 66.3 5.7 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 ELR16926.1 - 1.7e-15 57.0 0.5 3.5e-15 55.9 0.5 1.5 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Esterase PF00756.20 ELR16926.1 - 1.3e-05 24.9 0.0 1.8e-05 24.5 0.0 1.2 1 0 0 1 1 1 1 Putative esterase Ndr PF03096.14 ELR16926.1 - 6.9e-05 21.7 0.0 0.00013 20.8 0.0 1.4 2 0 0 2 2 2 1 Ndr family DUF676 PF05057.14 ELR16926.1 - 0.00018 21.1 0.0 0.00034 20.2 0.0 1.4 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Lipase_3 PF01764.25 ELR16926.1 - 0.025 14.4 0.0 0.047 13.6 0.0 1.4 1 0 0 1 1 1 0 Lipase (class 3) Ser_hydrolase PF06821.13 ELR16926.1 - 0.047 13.5 0.0 0.085 12.7 0.0 1.7 1 1 0 1 1 1 0 Serine hydrolase Peptidase_S15 PF02129.18 ELR16926.1 - 0.074 12.6 0.0 0.27 10.8 0.0 1.9 1 1 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) Abhydrolase_5 PF12695.7 ELR16926.1 - 0.11 12.3 0.0 0.57 9.9 0.0 1.9 2 0 0 2 2 2 0 Alpha/beta hydrolase family Abhydro_lipase PF04083.16 ELR16926.1 - 0.14 11.7 0.2 0.35 10.5 0.1 1.7 2 0 0 2 2 2 0 Partial alpha/beta-hydrolase lipase region DUF915 PF06028.11 ELR16926.1 - 0.15 11.3 0.0 0.4 10.0 0.0 1.6 2 0 0 2 2 2 0 Alpha/beta hydrolase of unknown function (DUF915) RhoGEF PF00621.20 ELR16927.1 - 4.3e-22 79.2 2.9 4.6e-22 79.1 0.3 2.0 2 0 0 2 2 2 1 RhoGEF domain IQ PF00612.27 ELR16927.1 - 1.2e-05 24.7 1.9 2.7e-05 23.6 1.9 1.6 1 0 0 1 1 1 1 IQ calmodulin-binding motif Redoxin PF08534.10 ELR16929.1 - 3.8e-33 114.3 0.1 4.7e-33 114.0 0.1 1.1 1 0 0 1 1 1 1 Redoxin AhpC-TSA PF00578.21 ELR16929.1 - 1.9e-15 56.9 0.0 2.6e-15 56.4 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family FYVE PF01363.21 ELR16930.1 - 1.2e-17 63.8 7.0 2.1e-17 63.0 7.0 1.5 1 0 0 1 1 1 1 FYVE zinc finger Hydrolase_4 PF12146.8 ELR16930.1 - 2.2e-14 53.3 0.0 5.3e-14 52.1 0.0 1.6 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 ELR16930.1 - 7.4e-13 48.7 0.0 1.4e-12 47.8 0.0 1.5 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 ELR16930.1 - 1.5e-09 38.8 0.0 2e-09 38.4 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.21 ELR16930.1 - 0.0017 17.8 0.9 0.0036 16.8 0.1 2.0 2 0 0 2 2 2 1 Prolyl oligopeptidase family DLH PF01738.18 ELR16930.1 - 0.011 15.3 2.4 0.041 13.4 0.1 2.6 2 1 0 2 2 2 0 Dienelactone hydrolase family Ndr PF03096.14 ELR16930.1 - 0.017 13.9 0.0 0.026 13.2 0.0 1.2 1 0 0 1 1 1 0 Ndr family UPF0227 PF05728.12 ELR16930.1 - 0.018 15.0 0.0 0.044 13.7 0.0 1.7 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0227) Abhydrolase_5 PF12695.7 ELR16930.1 - 0.029 14.1 0.0 0.051 13.4 0.0 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase family Thioesterase PF00975.20 ELR16930.1 - 0.048 13.8 0.2 0.048 13.8 0.2 2.3 2 0 0 2 2 2 0 Thioesterase domain Abhydrolase_3 PF07859.13 ELR16930.1 - 0.1 12.5 0.0 0.28 11.0 0.0 1.7 2 0 0 2 2 2 0 alpha/beta hydrolase fold Esterase PF00756.20 ELR16930.1 - 0.64 9.6 0.0 0.64 9.6 0.0 2.1 2 0 0 2 2 2 0 Putative esterase Rieske_2 PF13806.6 ELR16931.1 - 3.2e-10 39.9 0.0 4.4e-10 39.4 0.0 1.2 1 0 0 1 1 1 1 Rieske-like [2Fe-2S] domain Rieske PF00355.26 ELR16931.1 - 2.3e-06 27.4 0.0 3.7e-06 26.8 0.0 1.3 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain GTP1_OBG PF01018.22 ELR16932.1 - 3.4e-39 133.9 10.2 5.4e-39 133.3 10.2 1.3 1 0 0 1 1 1 1 GTP1/OBG MMR_HSR1 PF01926.23 ELR16932.1 - 1.8e-23 82.8 0.0 2.8e-23 82.2 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 ELR16932.1 - 2e-10 40.4 0.0 1.8e-09 37.3 0.0 2.1 1 1 0 1 1 1 1 Ferrous iron transport protein B Dynamin_N PF00350.23 ELR16932.1 - 0.0013 18.8 0.0 0.19 11.8 0.0 2.2 2 0 0 2 2 2 1 Dynamin family RsgA_GTPase PF03193.16 ELR16932.1 - 0.0034 17.3 0.0 0.55 10.1 0.0 2.3 2 0 0 2 2 2 1 RsgA GTPase PduV-EutP PF10662.9 ELR16932.1 - 0.0039 16.9 0.0 0.014 15.2 0.0 1.8 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation Arf PF00025.21 ELR16932.1 - 0.0057 16.1 0.0 0.016 14.7 0.0 1.8 1 1 0 1 1 1 1 ADP-ribosylation factor family MeaB PF03308.16 ELR16932.1 - 0.0079 15.2 0.0 0.41 9.6 0.0 2.3 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB ABC_tran PF00005.27 ELR16932.1 - 0.052 14.1 0.0 0.1 13.1 0.0 1.4 1 0 0 1 1 1 0 ABC transporter Gtr1_RagA PF04670.12 ELR16932.1 - 0.08 12.3 0.0 0.14 11.5 0.0 1.3 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region PARG_cat PF05028.14 ELR16933.1 - 3.1e-101 339.0 0.0 4.5e-101 338.5 0.0 1.1 1 0 0 1 1 1 1 Poly (ADP-ribose) glycohydrolase (PARG) NOA36 PF06524.12 ELR16933.1 - 2.3 7.5 7.2 3.9 6.7 7.2 1.3 1 0 0 1 1 1 0 NOA36 protein PARG_cat PF05028.14 ELR16934.1 - 1e-102 344.0 0.0 1.4e-102 343.5 0.0 1.1 1 0 0 1 1 1 1 Poly (ADP-ribose) glycohydrolase (PARG) Ank PF00023.30 ELR16935.1 - 2.1e-33 113.3 4.7 5.3e-06 26.6 0.0 6.4 6 0 0 6 6 6 6 Ankyrin repeat Ank_2 PF12796.7 ELR16935.1 - 5.4e-31 107.0 1.2 8.7e-12 45.5 0.2 5.2 3 1 1 4 4 4 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ELR16935.1 - 1.5e-27 95.6 6.7 4.3e-10 39.9 0.3 6.2 3 2 3 6 6 6 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 ELR16935.1 - 4.3e-27 91.2 4.3 0.00084 19.6 0.1 7.2 6 1 0 6 6 6 6 Ankyrin repeat Ank_5 PF13857.6 ELR16935.1 - 9e-21 73.7 6.6 0.00032 20.9 0.0 6.1 3 1 3 6 6 6 5 Ankyrin repeats (many copies) SPRY PF00622.28 ELR16935.1 - 2.5e-18 66.3 0.2 5e-18 65.4 0.2 1.5 1 0 0 1 1 1 1 SPRY domain Ank_2 PF12796.7 ELR16936.1 - 6.7e-107 350.3 8.6 2e-15 57.1 0.2 12.4 7 2 7 14 14 14 14 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ELR16936.1 - 1.7e-90 296.3 27.9 2.2e-10 40.8 0.0 18.6 7 7 12 19 19 19 18 Ankyrin repeats (many copies) Ank PF00023.30 ELR16936.1 - 4.5e-83 270.4 35.1 6.4e-05 23.2 0.0 23.1 24 0 0 24 24 24 13 Ankyrin repeat Ank_5 PF13857.6 ELR16936.1 - 1.3e-74 245.3 19.2 8.5e-08 32.3 0.0 17.0 7 4 9 18 18 18 17 Ankyrin repeats (many copies) Ank_3 PF13606.6 ELR16936.1 - 1e-71 228.3 19.9 0.00059 20.1 0.0 22.5 25 0 0 25 25 25 15 Ankyrin repeat MATH PF00917.26 ELR16936.1 - 0.014 15.5 0.1 0.036 14.2 0.1 1.6 1 0 0 1 1 1 0 MATH domain DUF572 PF04502.13 ELR16936.1 - 0.31 10.6 11.8 0.55 9.8 11.8 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF572) DUF740 PF05340.12 ELR16936.1 - 3 6.5 9.0 5.4 5.6 9.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF740) TRAPPC9-Trs120 PF08626.11 ELR16937.1 - 1.2e-05 23.0 0.0 1.6e-05 22.6 0.0 1.1 1 0 0 1 1 1 1 Transport protein Trs120 or TRAPPC9, TRAPP II complex subunit Aminotran_4 PF01063.19 ELR16938.1 - 3.9e-06 26.9 0.0 4.9e-06 26.6 0.0 1.1 1 0 0 1 1 1 1 Amino-transferase class IV Phosducin PF02114.16 ELR16939.1 - 1.2e-11 44.1 0.0 1.4e-11 43.8 0.0 1.1 1 0 0 1 1 1 1 Phosducin Thioredoxin PF00085.20 ELR16939.1 - 9.5e-05 22.3 0.0 0.00019 21.4 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin NDUF_B7 PF05676.13 ELR16940.1 - 2.1e-28 97.8 6.4 3.1e-28 97.3 6.4 1.3 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) Methyltransf_16 PF10294.9 ELR16941.1 - 3.1e-11 43.3 0.0 3.7e-11 43.1 0.0 1.1 1 0 0 1 1 1 1 Lysine methyltransferase COesterase PF00135.28 ELR16942.1 - 0.0013 17.7 0.2 0.014 14.3 0.2 2.0 1 1 0 1 1 1 1 Carboxylesterase family COesterase PF00135.28 ELR16943.1 - 8e-38 130.6 0.1 4.9e-37 128.0 0.1 1.8 1 1 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 ELR16943.1 - 0.0033 17.3 0.7 0.023 14.6 0.0 2.0 2 0 0 2 2 2 1 alpha/beta hydrolase fold HIT PF01230.23 ELR16944.1 - 5.2e-23 81.6 0.0 8.3e-23 81.0 0.0 1.3 1 0 0 1 1 1 1 HIT domain DcpS_C PF11969.8 ELR16944.1 - 1.3e-07 32.1 0.0 1.8e-07 31.6 0.0 1.2 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding CwfJ_C_1 PF04677.15 ELR16944.1 - 0.16 11.8 0.0 0.23 11.3 0.0 1.2 1 0 0 1 1 1 0 Protein similar to CwfJ C-terminus 1 Spermine_synth PF01564.17 ELR16945.1 - 6.3e-67 224.6 0.1 1.2e-66 223.7 0.0 1.4 2 0 0 2 2 2 1 Spermine/spermidine synthase domain Spermine_synt_N PF17284.2 ELR16945.1 - 2.8e-22 78.3 0.1 6.6e-22 77.1 0.1 1.7 1 0 0 1 1 1 1 Spermidine synthase tetramerisation domain Methyltransf_25 PF13649.6 ELR16945.1 - 2.9e-06 27.9 0.0 6e-06 26.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ELR16945.1 - 0.00047 20.8 0.2 0.0015 19.2 0.0 2.1 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_2 PF00891.18 ELR16945.1 - 0.0047 16.3 0.2 0.012 15.0 0.1 1.7 1 1 0 1 1 1 1 O-methyltransferase domain Methyltransf_18 PF12847.7 ELR16945.1 - 0.024 14.6 0.1 0.042 13.8 0.1 1.3 1 0 0 1 1 1 0 Methyltransferase domain MTS PF05175.14 ELR16945.1 - 0.054 13.0 0.0 0.071 12.7 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_30 PF05430.11 ELR16945.1 - 0.076 12.9 0.0 0.13 12.1 0.0 1.5 1 0 0 1 1 1 0 S-adenosyl-L-methionine-dependent methyltransferase Methyltransf_4 PF02390.17 ELR16945.1 - 0.16 11.4 0.1 0.62 9.5 0.0 2.0 2 1 0 2 2 2 0 Putative methyltransferase Acetyltransf_1 PF00583.25 ELR16947.1 - 4.7e-08 33.3 0.0 7.8e-08 32.6 0.0 1.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family FR47 PF08445.10 ELR16947.1 - 0.00037 20.4 0.0 0.00068 19.6 0.0 1.4 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_7 PF13508.7 ELR16947.1 - 0.0021 18.4 0.0 0.0044 17.4 0.0 1.5 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 ELR16947.1 - 0.014 15.4 0.0 0.033 14.3 0.0 1.7 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Glyco_hydro_125 PF06824.11 ELR16948.1 - 1.9e-119 399.3 0.0 7.3e-102 341.3 0.0 2.1 1 1 1 2 2 2 2 Metal-independent alpha-mannosidase (GH125) MutS_V PF00488.21 ELR16949.1 - 1.6e-65 220.7 0.5 3.1e-65 219.7 0.1 1.7 2 0 0 2 2 2 1 MutS domain V MutS_III PF05192.18 ELR16949.1 - 6.2e-30 104.8 0.1 6.2e-30 104.8 0.1 3.3 4 0 0 4 4 4 1 MutS domain III MutS_I PF01624.20 ELR16949.1 - 1.5e-21 76.8 0.0 3.2e-21 75.7 0.0 1.6 1 0 0 1 1 1 1 MutS domain I MutS_II PF05188.17 ELR16949.1 - 2.9e-12 47.1 0.0 1.7e-11 44.5 0.0 2.2 2 0 0 2 2 2 1 MutS domain II MutS_IV PF05190.18 ELR16949.1 - 1.4e-07 31.8 0.1 3.8e-07 30.3 0.1 1.8 1 0 0 1 1 1 1 MutS family domain IV RFX_DNA_binding PF02257.15 ELR16950.1 - 6.1e-08 33.2 0.1 3.8e-07 30.7 0.1 2.0 1 1 0 1 1 1 1 RFX DNA-binding domain Tir_receptor_N PF07490.11 ELR16950.1 - 0.002 18.0 0.5 0.0023 17.8 0.5 1.2 1 0 0 1 1 1 1 Translocated intimin receptor (Tir) N-terminus SPESP1 PF15754.5 ELR16950.1 - 0.0036 16.5 1.9 0.0044 16.2 1.9 1.1 1 0 0 1 1 1 1 Sperm equatorial segment protein 1 FTO_NTD PF12933.7 ELR16950.1 - 0.065 12.5 0.0 0.089 12.0 0.0 1.3 1 0 0 1 1 1 0 FTO catalytic domain Dicty_REP PF05086.12 ELR16950.1 - 1.9 6.3 3.2 2.2 6.1 3.2 1.0 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein DUF515 PF04415.12 ELR16950.1 - 2.9 6.2 5.6 3.8 5.8 5.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF515) RNA_pol_Rpb1_2 PF00623.20 ELR16951.1 - 5.8e-72 241.3 0.0 9.6e-72 240.6 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_1 PF04997.12 ELR16951.1 - 3.3e-60 204.0 0.3 6.7e-39 134.1 0.1 2.3 1 1 0 2 2 2 2 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_5 PF04998.17 ELR16951.1 - 1.5e-55 188.5 0.4 6.6e-30 104.4 0.3 2.2 1 1 0 2 2 2 2 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_3 PF04983.18 ELR16951.1 - 8.5e-37 126.5 0.0 1.7e-36 125.5 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_4 PF05000.17 ELR16951.1 - 1.4e-31 108.6 0.0 4.9e-31 106.9 0.0 2.0 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 4 UBM PF14377.6 ELR16951.1 - 0.16 11.5 0.5 0.36 10.3 0.5 1.6 1 0 0 1 1 1 0 Ubiquitin binding region Methyltransf_23 PF13489.6 ELR16952.1 - 5e-15 55.7 0.0 7.5e-15 55.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ELR16952.1 - 2.2e-12 47.0 0.0 4.2e-09 36.4 0.0 2.2 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_11 PF08241.12 ELR16952.1 - 3.5e-12 46.8 0.0 8.3e-12 45.6 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ELR16952.1 - 1.7e-11 44.7 0.0 1.3e-10 41.8 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ELR16952.1 - 4.4e-11 43.4 0.0 1.2e-10 42.0 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 ELR16952.1 - 1.4e-06 27.9 0.0 1.7e-05 24.3 0.0 2.4 3 0 0 3 3 3 1 ubiE/COQ5 methyltransferase family Methyltransf_9 PF08003.11 ELR16952.1 - 2.6e-05 23.3 0.0 4.9e-05 22.4 0.0 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF1698) MTS PF05175.14 ELR16952.1 - 0.02 14.5 0.0 0.11 12.0 0.0 2.0 1 1 0 1 1 1 0 Methyltransferase small domain TehB PF03848.14 ELR16952.1 - 0.041 13.3 0.0 9.7 5.5 0.1 2.3 2 0 0 2 2 2 0 Tellurite resistance protein TehB DUF4476 PF14771.6 ELR16953.1 - 5.5e-16 58.6 0.0 6e-16 58.5 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4476) CBS PF00571.28 ELR16954.1 - 2e-22 79.4 5.5 2.4e-10 40.7 0.3 4.3 4 0 0 4 4 4 4 CBS domain RVT_1 PF00078.27 ELR16955.1 - 0.012 15.1 0.0 0.02 14.4 0.0 1.2 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) CtIP_N PF10482.9 ELR16957.1 - 0.042 13.9 1.9 0.06 13.4 1.9 1.2 1 0 0 1 1 1 0 Tumour-suppressor protein CtIP N-terminal domain RNA_pol_Rpb1_5 PF04998.17 ELR16958.1 - 1e-57 195.6 0.2 1.3e-57 195.3 0.2 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 5 Ferrochelatase PF00762.19 ELR16958.1 - 4.1e-15 55.7 1.9 2.4e-14 53.1 0.1 2.6 2 1 0 2 2 2 1 Ferrochelatase Mito_carr PF00153.27 ELR16959.1 - 5.1e-70 231.5 3.2 7.3e-25 86.7 0.1 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein ACAS_N PF16177.5 ELR16959.1 - 0.082 12.8 0.6 0.16 11.9 0.6 1.4 1 0 0 1 1 1 0 Acetyl-coenzyme A synthetase N-terminus Fuseless PF15993.5 ELR16959.1 - 0.15 11.3 0.0 0.23 10.6 0.0 1.2 1 0 0 1 1 1 0 Fuseless Ferrochelatase PF00762.19 ELR16960.1 - 1.7e-10 40.5 0.0 2.3e-10 40.1 0.0 1.1 1 0 0 1 1 1 1 Ferrochelatase SPRY PF00622.28 ELR16961.1 - 1.1e-17 64.3 0.0 2.6e-17 63.1 0.0 1.6 2 0 0 2 2 2 1 SPRY domain BTB PF00651.31 ELR16961.1 - 6.8e-17 61.7 0.0 1.4e-16 60.7 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.15 ELR16961.1 - 3.1e-12 46.5 0.2 8.9e-09 35.4 0.1 2.4 2 0 0 2 2 2 2 BTB And C-terminal Kelch Neuralized PF07177.12 ELR16961.1 - 0.00025 21.1 0.0 0.00077 19.5 0.0 1.7 1 1 0 1 1 1 1 Neuralized DUF508 PF04370.12 ELR16961.1 - 0.57 9.9 13.4 0.019 14.7 6.6 2.0 3 0 0 3 3 3 0 Domain of unknown function (DUF508) RAP1 PF07218.11 ELR16961.1 - 2.3 6.4 4.7 3.3 5.9 4.7 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) RPN2_C PF18004.1 ELR16962.1 - 2.6e-48 164.0 15.3 2.6e-48 164.0 15.3 2.2 2 0 0 2 2 2 1 26S proteasome regulatory subunit RPN2 C-terminal domain PC_rep PF01851.22 ELR16962.1 - 3.7e-34 115.4 26.1 7.6e-06 26.1 0.0 9.0 9 0 0 9 9 8 6 Proteasome/cyclosome repeat HEAT_2 PF13646.6 ELR16962.1 - 3.8e-20 72.1 6.7 3.5e-14 53.0 0.1 5.1 3 1 3 6 6 6 4 HEAT repeats HEAT PF02985.22 ELR16962.1 - 3.6e-05 23.6 0.3 2.1 8.8 0.1 4.9 7 0 0 7 7 4 2 HEAT repeat HEAT_EZ PF13513.6 ELR16962.1 - 0.00016 22.1 5.4 0.16 12.5 0.2 5.3 4 1 2 6 6 6 2 HEAT-like repeat CENP-N PF05238.13 ELR16962.1 - 0.04 13.2 7.5 1.8 7.8 0.0 2.2 2 0 0 2 2 2 0 Kinetochore protein CHL4 like Vfa1 PF08432.10 ELR16962.1 - 0.2 12.0 18.7 0.6 10.4 16.4 2.3 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 Plasmodium_Vir PF05795.11 ELR16962.1 - 0.6 9.5 10.7 2.4 7.5 7.5 2.2 2 0 0 2 2 2 0 Plasmodium vivax Vir protein DDHD PF02862.17 ELR16962.1 - 0.78 9.9 3.7 0.55 10.4 1.3 1.9 2 0 0 2 2 2 0 DDHD domain Jak1_Phl PF17887.1 ELR16962.1 - 0.79 9.7 9.5 2 8.4 9.5 1.6 1 0 0 1 1 1 0 Jak1 pleckstrin homology-like domain DUF1682 PF07946.14 ELR16962.1 - 1.3 8.2 19.9 2.9 7.0 19.9 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) RNA_pol_Rpc4 PF05132.14 ELR16962.1 - 1.5 9.2 15.5 0.56 10.6 10.0 2.4 2 0 0 2 2 2 0 RNA polymerase III RPC4 TLP-20 PF06088.11 ELR16962.1 - 2.3 8.1 8.6 57 3.5 0.0 2.5 2 0 0 2 2 2 0 Nucleopolyhedrovirus telokin-like protein-20 (TLP20) DUF2151 PF10221.9 ELR16962.1 - 4.1 5.9 10.1 4.4 5.8 8.0 1.8 2 0 0 2 2 2 0 Cell cycle and development regulator NPR3 PF03666.13 ELR16962.1 - 4.7 5.9 8.8 10 4.8 8.8 1.5 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 UQ_con PF00179.26 ELR16963.1 - 4.6e-44 149.5 0.0 5.5e-44 149.2 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 ELR16963.1 - 6.6e-07 29.1 0.0 7.9e-07 28.8 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.22 ELR16963.1 - 0.13 12.6 0.0 0.16 12.3 0.0 1.3 1 0 0 1 1 1 0 RWD domain Cpn60_TCP1 PF00118.24 ELR16964.1 - 2.6e-90 303.4 16.9 5.2e-90 302.4 16.9 1.4 1 1 0 1 1 1 1 TCP-1/cpn60 chaperonin family Transglut_core PF01841.19 ELR16964.1 - 0.041 14.3 0.0 0.1 13.0 0.0 1.7 1 0 0 1 1 1 0 Transglutaminase-like superfamily SMBP PF16785.5 ELR16964.1 - 0.069 13.4 0.2 0.23 11.7 0.2 1.9 1 0 0 1 1 1 0 Small metal-binding protein GvpG PF05120.12 ELR16964.1 - 0.11 12.5 0.2 0.25 11.4 0.2 1.5 1 0 0 1 1 1 0 Gas vesicle protein G Methyltransf_16 PF10294.9 ELR16965.1 - 1.7e-06 27.9 0.0 2.4e-06 27.4 0.0 1.2 1 0 0 1 1 1 1 Lysine methyltransferase ELO PF01151.18 ELR16966.1 - 3.1e-66 223.5 13.5 3.7e-66 223.2 13.5 1.0 1 0 0 1 1 1 1 GNS1/SUR4 family Thiolase_N PF00108.23 ELR16969.1 - 7.1e-54 182.9 0.3 1.5e-53 181.8 0.3 1.5 1 1 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 ELR16969.1 - 2.3e-46 156.4 0.1 3.9e-46 155.7 0.1 1.4 1 0 0 1 1 1 1 Thiolase, C-terminal domain 3HCDH PF00725.22 ELR16969.1 - 3e-16 59.8 0.0 1.9e-11 44.4 0.0 2.8 2 0 0 2 2 2 2 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 3HCDH_N PF02737.18 ELR16970.1 - 3.4e-44 150.9 0.6 5.7e-44 150.1 0.6 1.3 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain ECH_1 PF00378.20 ELR16970.1 - 1.5e-36 126.0 0.0 3.3e-36 124.9 0.0 1.5 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 ELR16970.1 - 3.3e-27 95.9 0.1 9.7e-27 94.3 0.0 1.8 1 1 0 1 1 1 1 Enoyl-CoA hydratase/isomerase NAD_binding_2 PF03446.15 ELR16970.1 - 5.1e-05 23.5 0.4 0.00013 22.2 0.4 1.7 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase Peptidase_S49 PF01343.18 ELR16970.1 - 0.00052 20.0 0.1 0.29 11.1 0.0 2.7 3 0 0 3 3 3 2 Peptidase family S49 Methyltransf_11 PF08241.12 ELR16970.1 - 0.044 14.4 0.2 0.099 13.3 0.2 1.7 1 0 0 1 1 1 0 Methyltransferase domain F420_oxidored PF03807.17 ELR16970.1 - 0.065 13.8 0.3 0.21 12.2 0.3 1.9 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent RasGEF PF00617.19 ELR16971.1 - 9.1e-20 71.6 0.0 5e-18 65.9 0.0 2.6 1 1 1 2 2 2 1 RasGEF domain GPS2_interact PF15784.5 ELR16971.1 - 0.17 12.3 1.7 0.35 11.3 1.7 1.4 1 0 0 1 1 1 0 G-protein pathway suppressor 2-interacting domain adh_short_C2 PF13561.6 ELR16973.1 - 3e-63 213.5 5.0 3.4e-63 213.3 5.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 ELR16973.1 - 1.1e-55 188.1 1.8 1.5e-55 187.7 1.8 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 ELR16973.1 - 3.7e-11 43.3 2.1 5.5e-11 42.7 2.1 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 ELR16973.1 - 0.00074 19.0 1.6 0.0025 17.3 1.6 1.8 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 ELR16973.1 - 0.0095 15.1 0.5 0.017 14.3 0.5 1.4 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein THF_DHG_CYH_C PF02882.19 ELR16973.1 - 0.0097 15.2 0.2 0.026 13.8 0.2 1.7 2 0 0 2 2 2 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain DUF664 PF04978.12 ELR16973.1 - 0.11 12.9 0.7 0.19 12.1 0.1 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF664) NusB PF01029.18 ELR16973.1 - 0.13 12.5 0.0 0.2 11.9 0.0 1.2 1 0 0 1 1 1 0 NusB family DUF4246 PF14033.6 ELR16974.1 - 2e-63 215.1 0.0 6.7e-34 117.8 0.0 3.4 1 1 2 3 3 3 3 Protein of unknown function (DUF4246) 2OG-FeII_Oxy_5 PF13759.6 ELR16974.1 - 0.00018 21.9 0.3 0.00046 20.5 0.1 1.8 2 0 0 2 2 2 1 Putative 2OG-Fe(II) oxygenase DUF4051 PF13260.6 ELR16974.1 - 0.074 12.8 0.0 0.19 11.5 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF4051) BATS PF06968.13 ELR16974.1 - 0.12 12.5 0.0 0.24 11.6 0.0 1.5 1 0 0 1 1 1 0 Biotin and Thiamin Synthesis associated domain LRR_8 PF13855.6 ELR16975.1 - 4.5e-30 103.2 55.1 2.9e-10 39.8 7.6 6.1 5 2 3 8 8 8 6 Leucine rich repeat LRR_4 PF12799.7 ELR16975.1 - 1.7e-23 82.3 47.7 1.9e-06 28.1 6.6 7.4 4 2 4 9 9 9 8 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 ELR16975.1 - 5.1e-09 35.9 10.0 0.014 14.9 0.3 4.2 1 1 3 4 4 4 3 Leucine-rich repeat LRR_5 PF13306.6 ELR16975.1 - 4.9e-05 23.3 0.2 0.00014 21.8 0.1 1.9 1 1 0 1 1 1 1 BspA type Leucine rich repeat region (6 copies) DUF2322 PF10084.9 ELR16975.1 - 0.021 14.9 0.0 0.069 13.2 0.0 1.9 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2322) LRR_1 PF00560.33 ELR16975.1 - 0.055 14.0 1.6 0.055 14.0 1.6 9.8 9 3 1 10 10 10 0 Leucine Rich Repeat Peptidase_S8 PF00082.22 ELR16976.1 - 5.2e-34 117.9 8.9 1.2e-33 116.7 8.9 1.5 1 1 0 1 1 1 1 Subtilase family Inhibitor_I9 PF05922.16 ELR16976.1 - 0.00061 20.4 0.0 0.0012 19.5 0.0 1.5 1 0 0 1 1 1 1 Peptidase inhibitor I9 dCMP_cyt_deam_1 PF00383.23 ELR16977.1 - 3.8e-09 36.3 0.0 1.4e-08 34.5 0.0 2.0 1 1 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 ELR16977.1 - 0.02 14.6 3.7 0.068 12.9 3.6 1.8 1 1 0 1 1 1 0 MafB19-like deaminase Glyco_hydro_10 PF00331.20 ELR16978.1 - 8.9e-31 107.2 0.1 1.4e-30 106.6 0.1 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 10 CarboxypepD_reg PF13620.6 ELR16978.1 - 0.00028 21.1 4.0 0.37 11.1 0.0 3.7 3 0 0 3 3 3 2 Carboxypeptidase regulatory-like domain E1_DerP2_DerF2 PF02221.15 ELR16978.1 - 0.00068 20.1 0.1 0.0045 17.4 0.1 2.3 1 1 0 1 1 1 1 ML domain Big_1 PF02369.16 ELR16978.1 - 0.12 12.4 0.2 0.12 12.4 0.2 4.5 5 0 0 5 5 5 0 Bacterial Ig-like domain (group 1) Transglut_N PF00868.20 ELR16978.1 - 0.14 12.5 0.1 0.43 10.9 0.0 1.8 2 0 0 2 2 2 0 Transglutaminase family MG2 PF01835.19 ELR16978.1 - 0.15 12.5 0.5 7.2 7.1 0.1 3.0 3 0 0 3 3 3 0 MG2 domain Invasin_D3 PF09134.10 ELR16978.1 - 0.24 11.7 0.0 0.24 11.7 0.0 3.4 4 0 0 4 4 4 0 Invasin, domain 3 Transglut_core2 PF13369.6 ELR16979.1 - 1.6e-35 122.0 0.0 2.1e-35 121.6 0.0 1.1 1 0 0 1 1 1 1 Transglutaminase-like superfamily Transglut_core PF01841.19 ELR16979.1 - 0.016 15.6 0.0 0.029 14.8 0.0 1.4 1 0 0 1 1 1 0 Transglutaminase-like superfamily SR-25 PF10500.9 ELR16979.1 - 0.14 11.8 5.5 0.2 11.3 5.5 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein YfmQ PF10787.9 ELR16979.1 - 0.2 11.4 0.0 0.32 10.8 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised protein from bacillus cereus group F-box-like PF12937.7 ELR16980.1 - 7e-05 22.6 0.2 7e-05 22.6 0.2 1.8 2 0 0 2 2 2 1 F-box-like FA_desaturase PF00487.24 ELR16981.1 - 1.2e-21 77.7 24.1 1.2e-20 74.4 24.1 2.0 1 1 0 1 1 1 1 Fatty acid desaturase DUF3474 PF11960.8 ELR16981.1 - 0.036 14.3 0.0 0.068 13.4 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3474) DASH_Ask1 PF08655.10 ELR16981.1 - 0.074 13.0 0.4 0.21 11.5 0.1 1.9 2 0 0 2 2 2 0 DASH complex subunit Ask1 Ras PF00071.22 ELR16982.1 - 1.6e-55 187.1 0.2 1.9e-55 186.9 0.2 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR16982.1 - 7.4e-21 74.6 0.0 1.1e-20 74.0 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR16982.1 - 3.3e-11 42.9 0.0 4.3e-11 42.6 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 ELR16982.1 - 2.2e-05 24.1 0.1 3.3e-05 23.5 0.1 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 ELR16982.1 - 4.3e-05 23.5 0.0 0.015 15.2 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase FeoB_N PF02421.18 ELR16982.1 - 0.049 13.2 0.3 0.12 11.9 0.3 1.9 1 1 0 1 1 1 0 Ferrous iron transport protein B Laminin_G_3 PF13385.6 ELR16983.1 - 0.00088 19.4 0.0 0.0014 18.8 0.0 1.3 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Miga PF10265.9 ELR16984.1 - 0.046 12.7 2.0 0.052 12.5 2.0 1.0 1 0 0 1 1 1 0 Mitoguardin Filamin PF00630.19 ELR16985.1 - 2.4e-141 461.9 7.5 3.2e-20 72.9 0.0 12.2 12 0 0 12 12 12 12 Filamin/ABP280 repeat CH PF00307.31 ELR16985.1 - 7.4e-41 138.7 0.0 4.2e-21 75.2 0.0 2.3 2 0 0 2 2 2 2 Calponin homology (CH) domain Invasin_D3 PF09134.10 ELR16985.1 - 2.3e-19 69.5 12.0 0.0028 17.9 0.1 9.3 10 0 0 10 10 10 5 Invasin, domain 3 YtkA PF13115.6 ELR16985.1 - 4.7e-10 39.9 8.7 0.26 11.9 0.1 8.8 9 0 0 9 9 9 2 YtkA-like Y_Y_Y PF07495.13 ELR16985.1 - 6.1e-08 32.5 1.7 0.75 9.8 0.1 7.1 8 0 0 8 8 7 2 Y_Y_Y domain CAMSAP_CH PF11971.8 ELR16985.1 - 1.1e-06 28.4 0.0 0.0015 18.3 0.0 2.5 2 0 0 2 2 2 2 CAMSAP CH domain CopC PF04234.12 ELR16985.1 - 3.4e-06 28.0 8.2 20 6.3 0.0 8.8 9 0 0 9 9 9 0 CopC domain DUF5060 PF16586.5 ELR16985.1 - 3.4e-05 24.1 0.2 32 5.0 0.0 7.3 8 0 0 8 8 8 0 Domain of unknown function (DUF5060) Big_3_5 PF16640.5 ELR16985.1 - 0.0004 20.5 8.2 3.1 8.1 0.2 6.6 7 0 0 7 7 7 1 Bacterial Ig-like domain (group 3) Big_1 PF02369.16 ELR16985.1 - 0.00084 19.3 0.5 1.5 8.9 0.0 4.7 3 0 0 3 3 3 1 Bacterial Ig-like domain (group 1) PapC_C PF13953.6 ELR16985.1 - 0.082 12.7 0.4 0.7 9.7 0.1 2.8 2 0 0 2 2 2 0 PapC C-terminal domain DUF5011 PF16403.5 ELR16985.1 - 0.19 11.9 5.7 52 4.1 0.3 4.8 4 0 0 4 4 4 0 Domain of unknown function (DUF5011) BclA_C PF18573.1 ELR16985.1 - 0.23 11.4 0.2 99 2.9 0.0 4.4 5 0 0 5 5 5 0 BclA C-terminal domain PPC PF04151.15 ELR16985.1 - 1.8 9.8 14.7 34 5.6 0.1 6.5 7 0 0 7 7 6 0 Bacterial pre-peptidase C-terminal domain PKD PF00801.20 ELR16985.1 - 4.3 7.3 5.3 19 5.2 0.4 4.5 5 0 0 5 5 5 0 PKD domain Neurexophilin PF06312.12 ELR16985.1 - 9.3 5.6 5.9 1.3e+02 1.9 0.1 4.6 7 0 0 7 7 7 0 Neurexophilin DUF3586 PF12131.8 ELR16986.1 - 0.78 10.0 5.2 1.3 9.3 5.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3586) Peptidase_C1 PF00112.23 ELR16989.1 - 2.9e-41 141.9 0.1 4.7e-41 141.3 0.1 1.2 1 0 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.12 ELR16989.1 - 8.5e-15 54.9 7.7 1.5e-14 54.2 7.7 1.4 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) DUF2878 PF11086.8 ELR16989.1 - 0.1 12.8 0.0 0.2 11.8 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2878) UPF0730 PF15827.5 ELR16989.1 - 0.16 11.7 1.0 0.26 11.1 0.0 1.8 2 0 0 2 2 2 0 UPF0730 unknown protein family BclA_C PF18573.1 ELR16992.1 - 0.0078 16.1 0.9 0.0078 16.1 0.9 2.6 2 1 1 3 3 3 1 BclA C-terminal domain DUF3094 PF11293.8 ELR16993.1 - 0.034 13.9 0.1 0.063 13.0 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3094) SNARE PF05739.19 ELR16993.1 - 0.18 11.8 0.0 0.3 11.1 0.0 1.3 1 0 0 1 1 1 0 SNARE domain Ras PF00071.22 ELR16995.1 - 4.4e-57 192.2 0.0 5.1e-57 192.0 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR16995.1 - 2.8e-19 69.5 0.0 3.8e-19 69.1 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR16995.1 - 2.5e-08 33.6 0.0 2.9e-08 33.4 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 ELR16995.1 - 1.4e-05 24.8 0.1 4.8e-05 23.0 0.0 1.8 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 ELR16995.1 - 0.00026 21.1 0.0 0.00035 20.6 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase ATP_bind_1 PF03029.17 ELR16995.1 - 0.0091 15.8 0.3 0.073 12.8 0.0 2.0 1 1 1 2 2 2 1 Conserved hypothetical ATP binding protein Septin PF00735.18 ELR16995.1 - 0.12 11.7 0.0 0.18 11.1 0.0 1.3 1 0 0 1 1 1 0 Septin Acetyltransf_1 PF00583.25 ELR16996.1 - 2.2e-11 44.0 0.0 3.4e-11 43.4 0.0 1.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 ELR16996.1 - 6.8e-10 39.0 0.0 1.2e-09 38.2 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 ELR16996.1 - 2.6e-07 31.0 0.0 4.5e-07 30.2 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 ELR16996.1 - 5.1e-06 26.4 0.0 1.4e-05 24.9 0.0 1.7 2 0 0 2 2 2 1 FR47-like protein Acetyltransf_3 PF13302.7 ELR16996.1 - 0.00023 21.9 0.1 0.00032 21.4 0.1 1.6 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_13 PF13880.6 ELR16996.1 - 0.069 13.1 0.0 0.16 12.0 0.0 1.5 1 0 0 1 1 1 0 ESCO1/2 acetyl-transferase Acetyltransf_4 PF13420.7 ELR16996.1 - 0.11 12.6 0.0 0.17 12.0 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Ras PF00071.22 ELR16997.1 - 9.1e-16 57.9 0.0 1.2e-15 57.5 0.0 1.3 1 0 0 1 1 1 1 Ras family F-box-like PF12937.7 ELR16997.1 - 8.9e-11 41.5 0.1 2.2e-10 40.2 0.1 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ELR16997.1 - 6.9e-08 32.2 0.1 1.5e-07 31.1 0.1 1.6 1 0 0 1 1 1 1 F-box domain SOBP PF15279.6 ELR16997.1 - 0.037 14.6 1.0 0.043 14.4 1.0 1.1 1 0 0 1 1 1 0 Sine oculis-binding protein Sporozoite_P67 PF05642.11 ELR16997.1 - 0.14 10.3 7.7 0.22 9.6 7.7 1.4 1 0 0 1 1 1 0 Sporozoite P67 surface antigen PAP1 PF08601.10 ELR16997.1 - 0.26 11.0 11.7 0.36 10.5 11.7 1.2 1 0 0 1 1 1 0 Transcription factor PAP1 Apt1 PF10351.9 ELR16997.1 - 0.4 9.5 4.4 0.43 9.4 4.4 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain MGC-24 PF05283.11 ELR16997.1 - 0.48 10.9 13.2 2.5 8.5 9.3 2.3 2 0 0 2 2 2 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin SSP160 PF06933.11 ELR16997.1 - 1.3 7.1 15.2 1.8 6.7 15.2 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 Med3 PF11593.8 ELR16997.1 - 6.2 5.9 7.7 8.5 5.4 7.7 1.2 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal dCMP_cyt_deam_1 PF00383.23 ELR16998.1 - 5.1e-14 52.0 0.0 3.8e-13 49.2 0.0 1.9 2 0 0 2 2 2 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 ELR16998.1 - 8.1e-13 48.3 0.0 1e-12 48.0 0.0 1.3 1 0 0 1 1 1 1 MafB19-like deaminase SNAD4 PF18750.1 ELR16998.1 - 0.00019 21.5 0.0 0.00067 19.8 0.0 1.7 2 0 0 2 2 2 1 Secreted Novel AID/APOBEC-like Deaminase 4 NAD1 PF18778.1 ELR16998.1 - 0.0092 16.1 0.1 0.02 15.0 0.0 1.5 2 0 0 2 2 2 1 Novel AID APOBEC clade 1 APOBEC_N PF08210.11 ELR16998.1 - 0.043 13.7 0.0 0.049 13.5 0.0 1.2 1 0 0 1 1 1 0 APOBEC-like N-terminal domain Bd3614-deam PF14439.6 ELR16998.1 - 0.092 12.8 1.0 0.82 9.7 0.4 2.1 1 1 1 2 2 2 0 Bd3614-like deaminase APOBEC2 PF18772.1 ELR16998.1 - 0.098 12.7 0.1 0.18 11.9 0.0 1.4 2 0 0 2 2 2 0 APOBEC2 APOBEC4 PF18775.1 ELR16998.1 - 0.18 12.0 0.3 2.5 8.3 0.4 2.1 2 0 0 2 2 2 0 APOBEC4 APOBEC3 PF18771.1 ELR16998.1 - 0.2 11.7 0.0 0.38 10.9 0.0 1.4 1 0 0 1 1 1 0 APOBEC3 Reprolysin_5 PF13688.6 ELR16999.1 - 9.7e-14 52.0 0.0 1.5e-13 51.3 0.0 1.2 1 0 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_3 PF13582.6 ELR16999.1 - 1.1e-13 51.8 0.0 1.8e-13 51.1 0.0 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like CBM49 PF09478.10 ELR16999.1 - 2.8e-07 30.8 0.0 5.2e-07 29.9 0.0 1.4 1 0 0 1 1 1 1 Carbohydrate binding domain CBM49 Reprolysin_2 PF13574.6 ELR16999.1 - 2.5e-06 27.5 0.0 4.2e-06 26.8 0.0 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.6 ELR16999.1 - 9.3e-06 25.4 0.0 1.4e-05 24.8 0.0 1.2 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin PF01421.19 ELR16999.1 - 0.0052 16.7 0.0 0.0079 16.1 0.0 1.2 1 0 0 1 1 1 1 Reprolysin (M12B) family zinc metalloprotease CBM_2 PF00553.19 ELR16999.1 - 0.017 15.5 0.5 0.034 14.5 0.5 1.5 1 0 0 1 1 1 0 Cellulose binding domain Apt1 PF10351.9 ELR17000.1 - 2.7 6.7 11.6 3.5 6.4 11.6 1.3 1 0 0 1 1 1 0 Golgi-body localisation protein domain MMR_HSR1 PF01926.23 ELR17001.1 - 3.4e-10 40.0 0.1 5.3e-10 39.4 0.1 1.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 ELR17001.1 - 5.4e-09 36.2 0.1 1.7e-06 28.0 0.0 2.2 2 0 0 2 2 2 1 RsgA GTPase AIG1 PF04548.16 ELR17001.1 - 3.6e-07 29.7 0.1 5.8e-07 29.1 0.1 1.3 1 0 0 1 1 1 1 AIG1 family Dynamin_N PF00350.23 ELR17001.1 - 7.9e-06 26.0 0.5 3.9e-05 23.8 0.5 2.1 1 1 0 1 1 1 1 Dynamin family AAA_16 PF13191.6 ELR17001.1 - 3.2e-05 24.4 0.0 5.4e-05 23.6 0.0 1.5 1 1 0 1 1 1 1 AAA ATPase domain AAA_23 PF13476.6 ELR17001.1 - 3.6e-05 24.4 0.1 4.7e-05 24.0 0.1 1.3 1 0 0 1 1 1 1 AAA domain DUF815 PF05673.13 ELR17001.1 - 0.0001 21.6 0.0 0.00018 20.7 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_29 PF13555.6 ELR17001.1 - 0.0004 20.1 0.0 0.00081 19.1 0.0 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain IIGP PF05049.13 ELR17001.1 - 0.00053 19.2 0.1 0.001 18.2 0.1 1.4 1 1 0 1 1 1 1 Interferon-inducible GTPase (IIGP) ABC_tran PF00005.27 ELR17001.1 - 0.00079 20.0 0.0 0.0011 19.5 0.0 1.3 1 0 0 1 1 1 1 ABC transporter TniB PF05621.11 ELR17001.1 - 0.0011 18.4 0.0 0.0022 17.4 0.0 1.5 2 0 0 2 2 2 1 Bacterial TniB protein Roc PF08477.13 ELR17001.1 - 0.0013 18.9 0.1 0.0032 17.7 0.1 1.7 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase G-alpha PF00503.20 ELR17001.1 - 0.0031 16.7 0.9 1.8 7.7 0.1 2.1 1 1 0 2 2 2 2 G-protein alpha subunit IstB_IS21 PF01695.17 ELR17001.1 - 0.0037 17.0 0.1 0.048 13.4 0.0 2.1 1 1 1 2 2 2 1 IstB-like ATP binding protein RNA_helicase PF00910.22 ELR17001.1 - 0.0043 17.4 0.0 0.0092 16.4 0.0 1.6 1 0 0 1 1 1 1 RNA helicase Septin PF00735.18 ELR17001.1 - 0.0063 15.8 0.5 0.036 13.3 0.0 2.2 2 1 1 3 3 3 1 Septin Gtr1_RagA PF04670.12 ELR17001.1 - 0.0077 15.6 0.1 0.13 11.6 0.0 2.3 2 0 0 2 2 2 1 Gtr1/RagA G protein conserved region FeoB_N PF02421.18 ELR17001.1 - 0.013 15.1 0.1 0.19 11.2 0.0 2.1 2 0 0 2 2 2 0 Ferrous iron transport protein B Ras PF00071.22 ELR17001.1 - 0.022 14.4 0.2 0.065 12.8 0.2 1.9 1 1 0 1 1 1 0 Ras family PduV-EutP PF10662.9 ELR17001.1 - 0.028 14.2 0.4 0.28 10.9 0.4 2.1 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation Zeta_toxin PF06414.12 ELR17001.1 - 0.034 13.4 0.0 0.057 12.7 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin cobW PF02492.19 ELR17001.1 - 0.039 13.6 0.3 2.8 7.5 0.1 2.3 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_21 PF13304.6 ELR17001.1 - 0.039 13.8 0.1 0.051 13.4 0.1 1.2 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_7 PF12775.7 ELR17001.1 - 0.041 13.4 0.0 0.066 12.7 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_22 PF13401.6 ELR17001.1 - 0.044 14.0 0.0 0.074 13.3 0.0 1.4 1 1 0 1 1 1 0 AAA domain T2SSE PF00437.20 ELR17001.1 - 0.06 12.4 0.0 0.097 11.7 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein FtsK_SpoIIIE PF01580.18 ELR17001.1 - 0.063 12.6 0.0 0.098 12.0 0.0 1.3 1 0 0 1 1 1 0 FtsK/SpoIIIE family TsaE PF02367.17 ELR17001.1 - 0.067 13.2 0.0 0.11 12.4 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE SMC_N PF02463.19 ELR17001.1 - 0.12 11.7 0.0 0.18 11.2 0.0 1.3 1 0 0 1 1 1 0 RecF/RecN/SMC N terminal domain F-box-like PF12937.7 ELR17002.1 - 4.5e-11 42.4 1.7 7.2e-11 41.8 0.8 1.8 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 ELR17002.1 - 2.1e-05 24.3 4.5 4.6e-05 23.2 1.8 2.7 2 1 0 2 2 2 1 F-box domain eIF-5a PF01287.20 ELR17003.1 - 2.7e-09 37.0 0.0 4.3e-09 36.4 0.0 1.2 1 0 0 1 1 1 1 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold F-box-like PF12937.7 ELR17004.1 - 6.2e-10 38.8 0.3 1.1e-09 38.0 0.3 1.4 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ELR17004.1 - 9.2e-05 22.2 0.1 0.00017 21.4 0.1 1.4 1 0 0 1 1 1 1 F-box domain eIF-5a PF01287.20 ELR17005.1 - 5.6e-06 26.4 0.0 7.5e-06 26.0 0.0 1.2 1 0 0 1 1 1 1 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold tRNA-synt_2c PF01411.19 ELR17007.1 - 7.4e-12 44.6 0.1 1e-11 44.1 0.1 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (A) tRNA_SAD PF07973.14 ELR17007.1 - 5.8e-09 35.9 0.5 1.3e-08 34.8 0.5 1.6 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain Rho_N PF07498.12 ELR17010.1 - 1.1e-10 41.2 5.8 1.5e-08 34.4 0.3 2.4 2 0 0 2 2 2 2 Rho termination factor, N-terminal domain HeH PF12949.7 ELR17010.1 - 0.00026 20.6 1.0 0.017 14.8 0.2 3.4 3 0 0 3 3 3 1 HeH/LEM domain PAN_4 PF14295.6 ELR17011.1 - 4e-08 33.1 2.8 5.6e-08 32.6 2.8 1.2 1 0 0 1 1 1 1 PAN domain Y_Y_Y PF07495.13 ELR17012.1 - 0.0011 18.8 0.2 0.86 9.6 0.0 2.5 2 0 0 2 2 2 2 Y_Y_Y domain PKD PF00801.20 ELR17012.1 - 0.0073 16.1 1.3 0.35 10.7 0.1 3.5 3 1 1 4 4 4 1 PKD domain Cytomega_TRL10 PF06084.11 ELR17012.1 - 0.22 11.5 0.7 0.42 10.6 0.3 1.7 2 0 0 2 2 2 0 Cytomegalovirus TRL10 protein FeoB_associated PF12669.7 ELR17012.1 - 6.3 7.3 7.8 0.21 12.0 1.8 1.6 2 0 0 2 2 2 0 FeoB-associated Cys-rich membrane protein Pkinase_Tyr PF07714.17 ELR17014.1 - 5.5e-61 206.1 5.0 2.7e-33 115.4 0.7 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 ELR17014.1 - 5.8e-57 193.1 4.0 1.8e-29 103.0 0.4 2.1 2 0 0 2 2 2 2 Protein kinase domain APH PF01636.23 ELR17014.1 - 0.017 15.1 1.4 3.3 7.6 0.8 2.3 2 0 0 2 2 2 0 Phosphotransferase enzyme family Haspin_kinase PF12330.8 ELR17014.1 - 0.023 13.7 0.0 0.51 9.2 0.0 2.4 2 0 0 2 2 2 0 Haspin like kinase domain Kinase-like PF14531.6 ELR17014.1 - 0.099 11.9 0.0 0.23 10.8 0.0 1.5 2 0 0 2 2 2 0 Kinase-like DUF5368 PF17336.2 ELR17014.1 - 0.41 10.8 2.7 1.8 8.8 0.0 2.8 2 0 0 2 2 2 0 Family of unknown function (DUF5368) FixG_C PF11614.8 ELR17016.1 - 0.18 12.0 0.0 0.33 11.2 0.0 1.4 1 0 0 1 1 1 0 IG-like fold at C-terminal of FixG, putative oxidoreductase DUF4326 PF14216.6 ELR17017.1 - 6.4e-12 46.0 2.8 1.1e-11 45.3 2.8 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4326) GMC_oxred_N PF00732.19 ELR17018.1 - 2.3e-06 27.2 2.0 5.1e-06 26.1 2.0 1.5 1 1 0 1 1 1 1 GMC oxidoreductase Pyr_redox_2 PF07992.14 ELR17018.1 - 0.00015 21.1 0.2 0.00015 21.1 0.2 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 ELR17018.1 - 0.00053 19.2 0.2 0.00065 18.9 0.2 1.1 1 0 0 1 1 1 1 FAD binding domain FAD_binding_3 PF01494.19 ELR17018.1 - 0.00058 19.2 0.1 0.00078 18.8 0.1 1.1 1 0 0 1 1 1 1 FAD binding domain Lycopene_cycl PF05834.12 ELR17018.1 - 0.0013 17.8 0.0 0.0015 17.7 0.0 1.1 1 0 0 1 1 1 1 Lycopene cyclase protein HI0933_like PF03486.14 ELR17018.1 - 0.011 14.5 0.7 0.015 14.0 0.7 1.2 1 0 0 1 1 1 0 HI0933-like protein NAD_binding_8 PF13450.6 ELR17018.1 - 0.011 15.9 2.5 0.011 15.9 2.5 1.8 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.27 ELR17018.1 - 0.019 15.5 0.0 0.028 15.0 0.0 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 ELR17018.1 - 0.019 14.6 1.1 0.029 14.0 1.1 1.2 1 0 0 1 1 1 0 FAD dependent oxidoreductase GIDA PF01134.22 ELR17018.1 - 0.03 13.4 0.1 0.034 13.3 0.1 1.1 1 0 0 1 1 1 0 Glucose inhibited division protein A ApbA PF02558.16 ELR17018.1 - 0.12 12.0 1.0 0.18 11.5 1.0 1.2 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA FAD_oxidored PF12831.7 ELR17018.1 - 0.21 10.9 3.2 0.27 10.5 3.2 1.2 1 0 0 1 1 1 0 FAD dependent oxidoreductase UCR_TM PF02921.14 ELR17018.1 - 0.22 12.0 0.2 0.41 11.1 0.2 1.5 1 0 0 1 1 1 0 Ubiquinol cytochrome reductase transmembrane region GMC_oxred_C PF05199.13 ELR17019.1 - 5.5e-08 33.5 0.1 8.4e-08 32.8 0.1 1.2 1 0 0 1 1 1 1 GMC oxidoreductase Pkinase_Tyr PF07714.17 ELR17019.1 - 3.7e-07 29.7 0.0 4.8e-07 29.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ELR17019.1 - 0.00024 20.6 0.0 0.00032 20.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain CorA PF01544.18 ELR17021.1 - 1e-06 28.3 0.0 2e-06 27.4 0.0 1.5 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein ArAE_2_N PF10337.9 ELR17021.1 - 0.076 12.0 0.2 0.11 11.5 0.2 1.2 1 0 0 1 1 1 0 Putative ER transporter, 6TM, N-terminal LETM1 PF07766.13 ELR17022.1 - 3.4e-97 325.0 2.5 4.3e-97 324.7 2.5 1.1 1 0 0 1 1 1 1 LETM1-like protein SAP PF02037.27 ELR17022.1 - 0.00033 20.3 0.0 0.056 13.2 0.0 2.6 2 0 0 2 2 2 2 SAP domain CREPT PF16566.5 ELR17022.1 - 0.052 13.7 1.0 1.7 8.8 0.0 2.4 2 0 0 2 2 2 0 Cell-cycle alteration and expression-elevated protein in tumour tRNA-synt_1c PF00749.21 ELR17023.1 - 4.8e-100 334.5 0.0 6.1e-100 334.1 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain tRNA-synt_1c_C PF03950.18 ELR17023.1 - 1e-36 126.4 0.0 1.9e-36 125.6 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), anti-codon binding domain GST_C_2 PF13410.6 ELR17023.1 - 0.00017 21.5 0.1 0.00041 20.3 0.1 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 ELR17023.1 - 0.0018 18.5 0.1 0.0042 17.3 0.1 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 ELR17023.1 - 0.004 17.3 0.1 0.12 12.6 0.1 2.7 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain tRNA-synt_1e PF01406.19 ELR17023.1 - 0.02 14.3 0.0 0.036 13.4 0.0 1.4 1 0 0 1 1 1 0 tRNA synthetases class I (C) catalytic domain CM1 PF03026.15 ELR17025.1 - 0.14 11.5 0.0 0.15 11.4 0.0 1.0 1 0 0 1 1 1 0 Influenza C virus M1 protein T4_deiodinase PF00837.17 ELR17026.1 - 1.4e-19 70.4 0.0 5.5e-12 45.5 0.0 2.0 1 1 1 2 2 2 2 Iodothyronine deiodinase Pirin PF02678.16 ELR17027.1 - 9.1e-29 99.6 0.5 2.1e-28 98.4 0.3 1.6 2 0 0 2 2 2 1 Pirin Pirin_C_2 PF17954.1 ELR17027.1 - 8e-11 42.0 0.0 4.6e-10 39.5 0.0 2.1 2 0 0 2 2 2 1 Quercetinase C-terminal cupin domain Cupin_2 PF07883.11 ELR17027.1 - 3.7e-08 33.0 0.4 0.00013 21.6 0.1 2.4 2 0 0 2 2 2 2 Cupin domain F-box-like PF12937.7 ELR17028.1 - 0.0021 17.9 0.3 0.0039 17.1 0.3 1.5 1 0 0 1 1 1 1 F-box-like Presenilin PF01080.17 ELR17028.1 - 2.6 6.7 5.8 3.6 6.2 5.8 1.1 1 0 0 1 1 1 0 Presenilin CDC45 PF02724.14 ELR17028.1 - 9.1 4.4 6.9 12 4.0 6.9 1.1 1 0 0 1 1 1 0 CDC45-like protein F_actin_bund_C PF18060.1 ELR17029.1 - 4.2e-17 62.1 16.5 4.2e-17 62.1 16.5 4.2 2 1 1 3 3 3 1 F actin bundling C terminal DUF3584 PF12128.8 ELR17029.1 - 2.2 5.7 45.6 0.24 8.9 40.8 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3584) Rrn6 PF10214.9 ELR17029.1 - 4.9 5.5 11.4 6 5.2 11.4 1.0 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor 7tm_6 PF02949.20 ELR17030.1 - 0.23 10.5 0.3 0.35 9.9 0.3 1.1 1 0 0 1 1 1 0 7tm Odorant receptor RCC1 PF00415.18 ELR17031.1 - 2.2e-09 37.8 1.3 0.00011 22.8 0.1 2.0 2 0 0 2 2 2 2 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 ELR17031.1 - 0.0002 21.1 0.6 0.00024 20.8 0.6 1.2 1 0 0 1 1 1 1 Regulator of chromosome condensation (RCC1) repeat TPP_enzyme_C PF02775.21 ELR17032.1 - 2.1e-12 47.1 0.0 3.4e-12 46.4 0.0 1.3 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain TPP_enzyme_C PF02775.21 ELR17033.1 - 4.4e-12 46.1 1.9 5.1e-12 45.8 0.1 2.0 3 0 0 3 3 3 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain Ank_2 PF12796.7 ELR17034.1 - 2.2e-10 41.0 0.6 5.8e-05 23.6 0.1 4.1 1 1 2 4 4 4 2 Ankyrin repeats (3 copies) F-box-like PF12937.7 ELR17034.1 - 2.5e-08 33.7 5.1 2.5e-08 33.7 5.1 2.2 2 1 0 2 2 2 1 F-box-like F-box PF00646.33 ELR17034.1 - 6.4e-05 22.7 0.2 0.00015 21.5 0.2 1.5 1 0 0 1 1 1 1 F-box domain Ank_3 PF13606.6 ELR17034.1 - 0.00042 20.5 6.0 0.84 10.4 0.0 6.0 8 0 0 8 8 8 1 Ankyrin repeat Ank_4 PF13637.6 ELR17034.1 - 0.0082 16.7 2.8 4.5 8.0 0.1 4.0 4 1 0 4 4 4 2 Ankyrin repeats (many copies) Ank PF00023.30 ELR17034.1 - 0.024 15.1 6.9 0.93 10.1 0.0 5.5 5 1 1 6 6 6 0 Ankyrin repeat KfrA_N PF11740.8 ELR17034.1 - 0.096 13.4 0.2 0.18 12.5 0.2 1.5 1 0 0 1 1 1 0 Plasmid replication region DNA-binding N-term zf-CCHH PF10283.9 ELR17035.1 - 1e-06 28.6 1.8 2.4e-06 27.4 1.8 1.6 1 0 0 1 1 1 1 PBZ domain CENP-B_dimeris PF09026.10 ELR17035.1 - 0.011 16.1 0.2 0.011 16.1 0.2 2.7 2 0 0 2 2 2 0 Centromere protein B dimerisation domain Abhydrolase_6 PF12697.7 ELR17035.1 - 0.027 15.1 0.0 0.068 13.8 0.0 1.7 1 1 0 1 1 1 0 Alpha/beta hydrolase family Rtf2 PF04641.12 ELR17035.1 - 0.16 11.3 8.5 0.27 10.6 0.5 2.2 2 0 0 2 2 2 0 Rtf2 RING-finger DUF913 PF06025.12 ELR17035.1 - 0.32 9.9 3.4 2 7.3 0.0 2.2 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) RR_TM4-6 PF06459.12 ELR17035.1 - 0.89 9.3 9.8 5.5 6.7 3.3 2.3 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 CDC45 PF02724.14 ELR17035.1 - 2.7 6.2 17.2 0.58 8.4 1.0 2.7 3 0 0 3 3 3 0 CDC45-like protein DUF4746 PF15928.5 ELR17035.1 - 2.8 7.3 13.4 0.68 9.3 6.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4746) TLP-20 PF06088.11 ELR17035.1 - 3.6 7.4 10.1 7.3 6.5 2.1 2.4 2 0 0 2 2 2 0 Nucleopolyhedrovirus telokin-like protein-20 (TLP20) Phage_Gp17 PF17549.2 ELR17035.1 - 3.9 7.5 5.7 0.37 10.8 0.3 2.0 2 0 0 2 2 2 0 Gene Product 17 CPSF100_C PF13299.6 ELR17035.1 - 5.8 7.1 8.6 16 5.7 0.9 2.4 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal FAM176 PF14851.6 ELR17035.1 - 9.2 5.9 18.3 0.73 9.5 3.2 2.9 3 0 0 3 3 3 0 FAM176 family Pox_Ag35 PF03286.14 ELR17035.1 - 9.5 5.9 17.3 6 6.6 6.8 2.4 2 0 0 2 2 2 0 Pox virus Ag35 surface protein Herpes_UL6 PF01763.16 ELR17036.1 - 0.085 11.4 0.0 0.11 11.0 0.0 1.0 1 0 0 1 1 1 0 Herpesvirus UL6 like Ank_4 PF13637.6 ELR17037.1 - 4.3e-16 59.0 4.7 1.9e-06 28.3 0.0 7.7 5 2 2 7 7 7 4 Ankyrin repeats (many copies) Ank_2 PF12796.7 ELR17037.1 - 6.3e-15 55.5 5.6 9.1e-05 23.0 0.0 5.7 2 1 6 8 8 8 4 Ankyrin repeats (3 copies) Ank_5 PF13857.6 ELR17037.1 - 1.1e-10 41.5 1.2 0.14 12.6 0.0 6.0 3 1 2 6 6 6 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 ELR17037.1 - 2.7e-09 36.5 7.8 0.67 10.7 0.0 8.3 10 0 0 10 10 10 3 Ankyrin repeat Ank PF00023.30 ELR17037.1 - 5.3e-09 36.1 8.8 0.049 14.1 0.0 6.9 7 1 0 7 7 7 3 Ankyrin repeat F-box-like PF12937.7 ELR17037.1 - 3.5e-08 33.2 7.0 3.5e-08 33.2 4.0 2.5 2 1 0 2 2 2 1 F-box-like F-box PF00646.33 ELR17037.1 - 0.0004 20.2 0.3 0.00087 19.1 0.3 1.5 1 0 0 1 1 1 1 F-box domain F_actin_bund_C PF18060.1 ELR17038.1 - 3.7e-17 62.2 16.5 3.7e-17 62.2 16.5 4.0 1 1 1 3 3 3 1 F actin bundling C terminal Tli4_N PF18443.1 ELR17038.1 - 2.6 8.4 8.0 1.2 9.5 3.9 2.4 1 1 1 2 2 2 0 Tle cognate immunity protein 4 N-terminal domain DUF3450 PF11932.8 ELR17038.1 - 8.8 5.6 31.4 2.1 7.6 11.8 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) RINGv PF12906.7 ELR17039.1 - 1.3e-10 41.3 5.6 1.3e-10 41.3 5.6 2.2 2 0 0 2 2 2 1 RING-variant domain Mito_carr PF00153.27 ELR17040.1 - 5.5e-66 218.5 2.6 2.2e-21 75.6 0.0 3.9 3 1 0 3 3 3 3 Mitochondrial carrier protein GAD-like PF08887.11 ELR17040.1 - 0.69 9.7 0.0 0.69 9.7 0.0 2.0 3 0 0 3 3 3 0 GAD-like domain Glutaminase PF04960.15 ELR17042.1 - 5e-107 357.3 0.0 6.6e-107 356.9 0.0 1.1 1 0 0 1 1 1 1 Glutaminase Ank_2 PF12796.7 ELR17042.1 - 2.1e-10 41.1 0.1 4.6e-10 40.0 0.1 1.6 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ELR17042.1 - 2.3e-09 37.6 0.1 1.6e-08 34.9 0.0 2.3 1 1 2 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 ELR17042.1 - 3.3e-07 30.1 0.1 0.011 16.2 0.0 3.4 3 0 0 3 3 3 2 Ankyrin repeat Ank_5 PF13857.6 ELR17042.1 - 1.2e-06 28.7 0.2 3.7e-06 27.1 0.2 2.0 1 1 0 1 1 1 1 Ankyrin repeats (many copies) Ank PF00023.30 ELR17042.1 - 0.0001 22.6 0.1 0.0037 17.6 0.0 3.1 3 0 0 3 3 3 1 Ankyrin repeat EF-hand_7 PF13499.6 ELR17042.1 - 0.0013 19.2 1.0 0.0044 17.4 0.9 2.0 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 ELR17042.1 - 0.036 14.0 0.1 0.036 14.0 0.1 3.2 3 0 0 3 3 3 0 EF-hand domain EF-hand_1 PF00036.32 ELR17042.1 - 0.068 12.7 1.7 2.6 7.8 0.0 2.8 2 0 0 2 2 2 0 EF hand Ependymin PF00811.18 ELR17043.1 - 0.11 12.8 0.1 0.8 10.0 0.1 2.1 1 1 0 1 1 1 0 Ependymin FH2 PF02181.23 ELR17045.1 - 7e-86 288.7 11.2 3.4e-85 286.4 2.7 3.4 3 1 0 3 3 3 2 Formin Homology 2 Domain PilO PF04350.13 ELR17045.1 - 1.9 8.7 5.2 11 6.1 0.7 3.2 4 0 0 4 4 4 0 Pilus assembly protein, PilO CC2-LZ PF16516.5 ELR17045.1 - 1.9 8.9 5.8 0.49 10.8 1.8 2.1 2 0 0 2 2 2 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator Motilin_ghrelin PF04644.12 ELR17046.1 - 0.015 15.1 1.6 0.023 14.5 1.6 1.3 1 0 0 1 1 1 0 Motilin/ghrelin GTP_EFTU PF00009.27 ELR17047.1 - 2.4e-36 125.1 0.0 3.4e-36 124.6 0.0 1.1 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 ELR17047.1 - 1.8e-28 99.1 0.0 3.8e-28 98.0 0.0 1.5 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 ELR17047.1 - 3.2e-09 37.0 0.1 2.8e-08 34.0 0.1 2.3 2 0 0 2 2 2 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 ELR17047.1 - 1.9e-05 24.7 0.0 0.00029 20.9 0.0 2.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU_D4 PF14578.6 ELR17047.1 - 0.00084 19.2 0.1 0.0022 17.9 0.1 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 4 Nuf2 PF03800.14 ELR17048.1 - 6.3e-39 133.3 0.1 2.1e-38 131.6 0.1 1.9 1 0 0 1 1 1 1 Nuf2 family DHR10 PF18595.1 ELR17048.1 - 1e-21 77.2 20.8 1e-21 77.2 20.8 4.7 2 2 1 4 4 4 1 Designed helical repeat protein 10 domain MscS_porin PF12795.7 ELR17048.1 - 0.0041 16.7 47.3 0.0073 15.9 22.7 2.9 2 1 2 4 4 4 2 Mechanosensitive ion channel porin domain Bacillus_HBL PF05791.11 ELR17048.1 - 0.012 15.5 7.1 0.012 15.5 7.1 3.4 1 1 1 3 3 3 0 Bacillus haemolytic enterotoxin (HBL) DUF4852 PF16144.5 ELR17048.1 - 0.048 13.8 0.9 0.048 13.8 0.9 3.6 3 1 0 3 3 3 0 Domain of unknown function (DUF4852) AAA_13 PF13166.6 ELR17048.1 - 0.42 9.2 39.9 0.33 9.5 3.8 2.1 1 1 0 2 2 2 0 AAA domain Golgin_A5 PF09787.9 ELR17048.1 - 0.95 8.9 54.5 1.5 8.2 12.2 3.1 1 1 2 3 3 3 0 Golgin subfamily A member 5 TPR_MLP1_2 PF07926.12 ELR17048.1 - 4.8 7.2 60.1 0.25 11.4 7.9 3.7 2 2 1 3 3 3 0 TPR/MLP1/MLP2-like protein Y_phosphatase2 PF03162.13 ELR17049.1 - 3e-42 144.0 0.0 4.4e-42 143.4 0.0 1.2 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase3 PF13350.6 ELR17049.1 - 0.051 13.5 0.0 0.11 12.5 0.0 1.5 1 1 0 1 1 1 0 Tyrosine phosphatase family Y_phosphatase PF00102.27 ELR17049.1 - 0.081 12.5 0.1 0.12 11.9 0.1 1.2 1 0 0 1 1 1 0 Protein-tyrosine phosphatase Pap_E4 PF02711.14 ELR17049.1 - 0.15 13.1 2.8 0.28 12.2 2.8 1.4 1 0 0 1 1 1 0 E4 protein DJ-1_PfpI PF01965.24 ELR17050.1 - 1.6e-14 54.0 0.0 1.5e-12 47.6 0.0 2.7 1 1 0 1 1 1 1 DJ-1/PfpI family ThiJ_like PF17124.5 ELR17050.1 - 1.8e-06 27.8 0.0 4.4e-06 26.5 0.0 1.5 1 1 0 1 1 1 1 ThiJ/PfpI family-like Snf7 PF03357.21 ELR17051.1 - 9.5e-13 48.1 10.9 1.2e-12 47.8 10.9 1.1 1 0 0 1 1 1 1 Snf7 Ist1 PF03398.14 ELR17051.1 - 0.033 14.1 5.2 0.067 13.1 5.2 1.5 1 1 0 1 1 1 0 Regulator of Vps4 activity in the MVB pathway Cnn_1N PF07989.11 ELR17051.1 - 0.043 14.0 7.7 1 9.5 0.1 3.2 2 1 1 3 3 3 0 Centrosomin N-terminal motif 1 DUF2652 PF10851.8 ELR17051.1 - 0.12 12.5 1.0 2.1 8.5 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2652) PilJ PF13675.6 ELR17051.1 - 0.12 12.4 5.4 6.8 6.8 0.1 2.9 1 1 2 3 3 3 0 Type IV pili methyl-accepting chemotaxis transducer N-term Fes1 PF08609.10 ELR17051.1 - 0.95 10.4 5.6 0.79 10.6 3.3 2.2 2 1 0 2 2 2 0 Nucleotide exchange factor Fes1 Peptidase_M1_N PF17900.1 ELR17052.1 - 1.3e-43 149.4 0.0 1.6e-43 149.1 0.0 1.0 1 0 0 1 1 1 1 Peptidase M1 N-terminal domain Peptidase_M1 PF01433.20 ELR17053.1 - 5.9e-82 274.5 0.9 8.4e-82 274.0 0.9 1.2 1 0 0 1 1 1 1 Peptidase family M1 domain ERAP1_C PF11838.8 ELR17053.1 - 4.2e-75 253.2 0.0 7e-75 252.5 0.0 1.4 1 0 0 1 1 1 1 ERAP1-like C-terminal domain CBS PF00571.28 ELR17054.1 - 3.3e-10 40.2 2.8 3.5e-05 24.2 0.1 2.8 2 0 0 2 2 2 2 CBS domain Cellulase PF00150.18 ELR17055.1 - 3e-27 95.8 3.3 1.4e-18 67.4 0.2 2.2 2 0 0 2 2 2 2 Cellulase (glycosyl hydrolase family 5) NYD-SP28_assoc PF14775.6 ELR17057.1 - 0.028 14.5 2.6 0.044 13.9 0.4 2.2 2 0 0 2 2 2 0 Sperm tail C-terminal domain DUF2605 PF10792.9 ELR17057.1 - 0.035 14.0 0.4 0.061 13.2 0.1 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2605) Pox_P35 PF03213.14 ELR17057.1 - 0.086 12.1 0.0 0.12 11.6 0.0 1.1 1 0 0 1 1 1 0 Poxvirus P35 protein DUF2207 PF09972.9 ELR17058.1 - 0.0091 14.8 2.6 0.0096 14.7 1.9 1.3 1 1 0 1 1 1 1 Predicted membrane protein (DUF2207) SEO_C PF14577.6 ELR17058.1 - 0.012 15.1 0.4 0.081 12.3 0.0 2.2 2 1 0 2 2 2 0 Sieve element occlusion C-terminus TrbC PF04956.13 ELR17058.1 - 0.038 14.2 6.1 1.9 8.7 4.1 2.7 2 0 0 2 2 2 0 TrbC/VIRB2 family DUF3043 PF11241.8 ELR17058.1 - 0.097 12.7 2.2 0.15 12.1 2.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3043) IRK PF01007.20 ELR17058.1 - 0.1 12.4 0.0 0.1 12.4 0.0 2.3 2 1 1 3 3 3 0 Inward rectifier potassium channel transmembrane domain RasGAP_C PF03836.15 ELR17058.1 - 0.12 12.5 3.6 0.35 11.0 0.5 2.5 2 1 0 2 2 2 0 RasGAP C-terminus Cauli_DNA-bind PF03310.13 ELR17058.1 - 1.8 8.6 6.4 0.51 10.4 1.5 2.1 1 1 0 2 2 2 0 Caulimovirus DNA-binding protein BTB_2 PF02214.22 ELR17059.1 - 2.3e-08 34.3 0.0 2.7e-08 34.0 0.0 1.1 1 0 0 1 1 1 1 BTB/POZ domain PAN_4 PF14295.6 ELR17060.1 - 3.3e-07 30.1 4.7 5.3e-07 29.5 4.7 1.4 1 1 0 1 1 1 1 PAN domain MANEC PF07502.14 ELR17060.1 - 0.023 15.0 3.2 0.023 14.9 2.3 1.5 1 1 0 1 1 1 0 MANEC domain PAN_2 PF08276.11 ELR17060.1 - 0.051 13.7 2.8 0.068 13.3 2.8 1.3 1 0 0 1 1 1 0 PAN-like domain FeoB_associated PF12669.7 ELR17060.1 - 0.51 10.8 9.8 2.3e+02 2.3 9.8 2.3 1 1 0 1 1 1 0 FeoB-associated Cys-rich membrane protein PAN_4 PF14295.6 ELR17061.1 - 1.1e-07 31.7 2.0 1.1e-07 31.7 2.0 2.0 1 1 2 3 3 3 1 PAN domain PAN_2 PF08276.11 ELR17061.1 - 0.024 14.7 3.0 0.033 14.3 3.0 1.3 1 0 0 1 1 1 0 PAN-like domain FixQ PF05545.11 ELR17061.1 - 0.12 12.3 0.5 0.22 11.5 0.5 1.3 1 0 0 1 1 1 0 Cbb3-type cytochrome oxidase component FixQ Peptidase_C1 PF00112.23 ELR17062.1 - 1.8e-39 136.1 7.9 2.8e-23 83.2 0.5 2.2 1 1 1 2 2 2 2 Papain family cysteine protease Inhibitor_I29 PF08246.12 ELR17062.1 - 3.8e-12 46.4 5.8 3.8e-12 46.4 5.8 1.8 2 0 0 2 2 2 1 Cathepsin propeptide inhibitor domain (I29) Peptidase_C1_2 PF03051.15 ELR17062.1 - 0.005 15.7 0.0 0.0072 15.1 0.0 1.2 1 0 0 1 1 1 1 Peptidase C1-like family UDG PF03167.19 ELR17063.1 - 4.9e-12 46.1 0.0 7.4e-12 45.5 0.0 1.2 1 0 0 1 1 1 1 Uracil DNA glycosylase superfamily F-box-like PF12937.7 ELR17063.1 - 6.9e-07 29.1 0.0 2e-06 27.6 0.0 1.8 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ELR17063.1 - 0.0016 18.3 3.6 0.0039 17.0 1.4 2.9 2 1 1 3 3 3 1 F-box domain PCNA_N PF00705.18 ELR17065.1 - 3.6e-27 94.6 1.4 7.1e-27 93.6 1.4 1.5 1 0 0 1 1 1 1 Proliferating cell nuclear antigen, N-terminal domain PCNA_C PF02747.15 ELR17065.1 - 2.9e-24 85.7 0.1 5.8e-24 84.7 0.1 1.6 1 0 0 1 1 1 1 Proliferating cell nuclear antigen, C-terminal domain dNK PF01712.19 ELR17066.1 - 1.5e-09 38.0 0.0 1.6e-09 37.9 0.0 1.0 1 0 0 1 1 1 1 Deoxynucleoside kinase Thymidylate_kin PF02223.17 ELR17066.1 - 0.014 15.1 0.0 0.016 14.9 0.0 1.2 1 0 0 1 1 1 0 Thymidylate kinase Prok-E2_C PF14459.6 ELR17066.1 - 0.043 14.0 0.0 1.5 9.0 0.0 2.1 2 0 0 2 2 2 0 Prokaryotic E2 family C T6PP_N PF18572.1 ELR17067.1 - 0.051 13.4 0.2 0.059 13.2 0.2 1.1 1 0 0 1 1 1 0 Trehalose-6-phosphate phosphatase N-terminal helical bundle domain DHFR_1 PF00186.19 ELR17069.1 - 9e-35 119.7 0.0 1.2e-34 119.3 0.0 1.2 1 0 0 1 1 1 1 Dihydrofolate reductase Lipase_3 PF01764.25 ELR17069.1 - 3.4e-27 95.1 0.0 5e-27 94.5 0.0 1.3 1 0 0 1 1 1 1 Lipase (class 3) Abhydrolase_6 PF12697.7 ELR17069.1 - 0.028 15.0 2.1 0.042 14.5 1.2 1.7 1 1 1 2 2 2 0 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 ELR17069.1 - 0.087 12.1 0.1 0.14 11.4 0.1 1.2 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 ELR17069.1 - 0.16 11.6 0.1 0.26 10.9 0.1 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold 5_3_exonuc_N PF02739.16 ELR17072.1 - 0.072 13.0 0.0 0.12 12.2 0.0 1.4 1 0 0 1 1 1 0 5'-3' exonuclease, N-terminal resolvase-like domain Phage_Coat_B PF05356.11 ELR17073.1 - 0.0071 16.2 0.2 0.02 14.8 0.2 1.7 1 0 0 1 1 1 1 Phage Coat protein B RskA PF10099.9 ELR17073.1 - 0.017 15.4 1.3 0.028 14.7 1.3 1.3 1 0 0 1 1 1 0 Anti-sigma-K factor rskA DUF4690 PF15756.5 ELR17073.1 - 0.58 10.8 2.6 0.38 11.4 0.4 1.8 2 0 0 2 2 2 0 Small Novel Rich in Cartilage CRM1_C PF08767.11 ELR17074.1 - 0.0064 15.7 0.7 0.018 14.3 0.7 1.8 1 0 0 1 1 1 1 CRM1 C terminal IBN_N PF03810.19 ELR17075.1 - 1.2e-06 28.3 0.0 2.6e-06 27.2 0.0 1.5 1 0 0 1 1 1 1 Importin-beta N-terminal domain RRM_1 PF00076.22 ELR17076.1 - 1.1e-27 95.7 0.0 2.5e-14 52.8 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 ELR17076.1 - 5.8e-08 32.6 0.0 2.5e-05 24.2 0.0 2.4 2 0 0 2 2 2 2 Nup53/35/40-type RNA recognition motif RRM_occluded PF16842.5 ELR17076.1 - 0.0023 17.8 0.0 0.064 13.1 0.0 2.4 2 0 0 2 2 2 1 Occluded RNA-recognition motif RRM_5 PF13893.6 ELR17076.1 - 0.044 13.4 0.0 0.69 9.5 0.0 2.2 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-AN1 PF01428.16 ELR17077.1 - 3.8e-06 26.9 15.6 0.0012 18.9 3.4 3.0 2 1 1 3 3 3 2 AN1-like Zinc finger FYDLN_acid PF09538.10 ELR17077.1 - 0.018 15.7 0.0 0.1 13.3 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (FYDLN_acid) Cys_rich_CPXG PF14255.6 ELR17077.1 - 0.038 13.9 0.4 3.3 7.7 0.1 2.6 2 0 0 2 2 2 0 Cysteine-rich CPXCG CpXC PF14353.6 ELR17077.1 - 0.04 14.0 0.1 0.22 11.6 0.0 2.0 2 0 0 2 2 2 0 CpXC protein EndoU_bacteria PF14436.6 ELR17077.1 - 0.071 13.5 0.0 0.12 12.8 0.0 1.3 1 0 0 1 1 1 0 Bacterial EndoU nuclease zf-Di19 PF05605.12 ELR17077.1 - 2.2 8.7 6.8 1.8 8.9 0.1 2.4 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding zf-ribbon_3 PF13248.6 ELR17077.1 - 2.6 7.6 6.9 9.1 5.8 0.6 2.9 3 0 0 3 3 3 0 zinc-ribbon domain Mannosidase_ig PF17786.1 ELR17078.1 - 3.6e-16 59.5 1.5 7.5e-16 58.5 1.5 1.6 1 0 0 1 1 1 1 Mannosidase Ig/CBM-like domain Ig_mannosidase PF17753.1 ELR17078.1 - 2.2e-12 46.5 0.0 1.3e-11 44.1 0.0 2.3 2 0 0 2 2 2 1 Ig-fold domain Glyco_hydro_2 PF00703.21 ELR17078.1 - 1.3e-07 32.2 0.0 1e-05 26.1 0.0 2.7 2 0 0 2 2 2 1 Glycosyl hydrolases family 2 Exo_endo_phos PF03372.23 ELR17079.1 - 0.0035 16.9 0.0 0.0054 16.3 0.0 1.5 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family tRNA_SAD PF07973.14 ELR17080.1 - 2.8e-07 30.5 0.2 5.2e-07 29.7 0.2 1.4 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain DHHA1 PF02272.19 ELR17080.1 - 0.13 12.7 2.4 0.29 11.6 2.4 1.6 1 0 0 1 1 1 0 DHHA1 domain Ras PF00071.22 ELR17081.1 - 3.1e-21 75.6 0.0 6.4e-21 74.6 0.0 1.5 1 1 0 1 1 1 1 Ras family Roc PF08477.13 ELR17081.1 - 4.1e-14 52.8 0.0 7.5e-14 52.0 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase F-box-like PF12937.7 ELR17081.1 - 7.4e-08 32.2 1.1 1.4e-07 31.3 1.1 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ELR17081.1 - 2.8e-07 30.3 1.2 6.6e-07 29.1 1.2 1.6 1 0 0 1 1 1 1 F-box domain F-box_4 PF15966.5 ELR17081.1 - 0.0024 17.8 0.0 0.006 16.4 0.0 1.8 2 0 0 2 2 2 1 F-box Arf PF00025.21 ELR17081.1 - 0.011 15.1 0.1 0.016 14.7 0.1 1.2 1 0 0 1 1 1 0 ADP-ribosylation factor family Lbh PF15317.6 ELR17081.1 - 0.088 13.7 0.1 0.65 10.9 0.0 2.0 2 0 0 2 2 2 0 Cardiac transcription factor regulator, Developmental protein WD40 PF00400.32 ELR17082.1 - 9e-27 92.8 27.4 1.1e-05 26.1 0.7 7.0 7 0 0 7 7 7 6 WD domain, G-beta repeat F-box-like PF12937.7 ELR17082.1 - 3.3e-10 39.7 0.0 5.6e-10 39.0 0.0 1.4 1 0 0 1 1 1 1 F-box-like Nup160 PF11715.8 ELR17082.1 - 1.3e-05 24.1 7.7 0.019 13.7 0.1 4.6 3 2 2 5 5 5 3 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ELR17082.1 - 0.0026 18.0 0.9 5.3 7.4 0.1 4.1 3 2 1 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ELR17082.1 - 0.0046 16.3 0.2 0.84 8.9 0.0 2.2 2 0 0 2 2 2 2 WD40-like domain F-box PF00646.33 ELR17082.1 - 0.012 15.5 0.1 0.021 14.7 0.1 1.5 1 0 0 1 1 1 0 F-box domain DUF1513 PF07433.11 ELR17082.1 - 0.036 13.1 0.1 0.96 8.5 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1513) Coatomer_WDAD PF04053.14 ELR17082.1 - 0.14 11.2 0.2 0.24 10.4 0.2 1.2 1 0 0 1 1 1 0 Coatomer WD associated region PALB2_WD40 PF16756.5 ELR17082.1 - 0.19 10.6 7.7 8 5.3 0.0 3.8 2 2 2 4 4 4 0 Partner and localizer of BRCA2 WD40 domain PBP1_TM PF14812.6 ELR17083.1 - 0.17 12.2 6.3 0.44 10.9 6.3 1.6 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal HPP PF04982.13 ELR17084.1 - 6.4e-40 136.1 8.1 6.4e-40 136.1 8.1 1.7 2 0 0 2 2 2 1 HPP family Phage_holin_3_3 PF16083.5 ELR17084.1 - 0.27 11.4 5.9 0.92 9.7 0.0 2.8 2 1 0 2 2 2 0 LydA holin phage, holin superfamily III RlaP PF10127.9 ELR17085.1 - 5.2e-06 26.2 0.1 0.00013 21.6 0.0 2.2 2 0 0 2 2 2 1 RNA repair pathway DNA polymerase beta family Polbeta PF18765.1 ELR17085.1 - 9.3e-06 25.6 0.0 1.8e-05 24.8 0.0 1.4 1 0 0 1 1 1 1 Polymerase beta, Nucleotidyltransferase NTP_transf_2 PF01909.23 ELR17085.1 - 1.3e-05 25.3 0.0 3.3e-05 24.1 0.0 1.7 1 0 0 1 1 1 1 Nucleotidyltransferase domain Adeno_PVIII PF01310.18 ELR17085.1 - 0.12 11.9 0.0 0.27 10.8 0.0 1.5 2 0 0 2 2 2 0 Adenovirus hexon associated protein, protein VIII NAP PF00956.18 ELR17086.1 - 4.2e-29 101.6 18.3 1.3e-28 100.0 17.7 2.4 1 1 0 1 1 1 1 Nucleosome assembly protein (NAP) Hemagglutinin PF00509.18 ELR17086.1 - 0.09 11.2 0.3 0.12 10.7 0.3 1.1 1 0 0 1 1 1 0 Haemagglutinin Hamartin PF04388.12 ELR17086.1 - 0.96 8.0 7.5 0.99 8.0 7.5 1.1 1 0 0 1 1 1 0 Hamartin protein SOG2 PF10428.9 ELR17086.1 - 7.4 5.6 10.4 10 5.2 10.4 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein Methyltransf_32 PF13679.6 ELR17087.1 - 4.6e-06 26.7 1.3 4.4e-05 23.5 1.3 2.2 1 1 0 1 1 1 1 Methyltransferase domain zf-CCCH_4 PF18044.1 ELR17087.1 - 4.4e-05 23.2 4.5 0.0001 22.0 4.5 1.7 1 0 0 1 1 1 1 CCCH-type zinc finger Torus PF16131.5 ELR17087.1 - 0.00024 21.8 0.2 0.001 19.7 0.1 2.1 2 0 0 2 2 2 1 Torus domain tRNA_anti-codon PF01336.25 ELR17087.1 - 0.0029 17.5 0.0 0.016 15.2 0.0 2.2 1 1 0 1 1 1 1 OB-fold nucleic acid binding domain zf_CCCH_4 PF18345.1 ELR17087.1 - 0.0054 16.8 9.8 0.0098 15.9 9.8 1.5 1 0 0 1 1 1 1 Zinc finger domain zf-CCCH_3 PF15663.5 ELR17087.1 - 0.0074 16.5 0.5 0.022 15.0 0.1 1.9 2 0 0 2 2 2 1 Zinc-finger containing family zf-CCCH PF00642.24 ELR17087.1 - 0.017 15.0 4.3 0.032 14.1 4.3 1.5 1 0 0 1 1 1 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Joubert PF15392.6 ELR17087.1 - 0.16 11.6 2.1 0.38 10.4 2.1 1.6 1 0 0 1 1 1 0 Joubert syndrome-associated DUF3244 PF11589.8 ELR17088.1 - 0.2 11.7 0.0 0.45 10.6 0.0 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF3244) Nop14 PF04147.12 ELR17089.1 - 0.0008 17.8 20.6 0.0012 17.2 20.6 1.2 1 0 0 1 1 1 1 Nop14-like family SDA1 PF05285.12 ELR17089.1 - 0.0062 16.0 23.4 0.0062 16.0 23.4 1.7 2 0 0 2 2 2 1 SDA1 SAPS PF04499.15 ELR17089.1 - 0.24 10.1 4.3 0.32 9.7 4.3 1.2 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein NPR3 PF03666.13 ELR17089.1 - 2.5 6.8 7.2 3.9 6.1 7.2 1.3 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 RNA_pol_3_Rpc31 PF11705.8 ELR17089.1 - 4.9 7.3 29.2 1.8 8.8 26.1 1.9 2 0 0 2 2 2 0 DNA-directed RNA polymerase III subunit Rpc31 BUD22 PF09073.10 ELR17089.1 - 5.6 6.2 27.9 3.7 6.8 25.5 1.7 2 0 0 2 2 2 0 BUD22 VWA_3 PF13768.6 ELR17090.1 - 5.2e-24 85.0 0.0 2.6e-21 76.2 0.0 2.4 1 1 0 1 1 1 1 von Willebrand factor type A domain U-box PF04564.15 ELR17090.1 - 3.8e-13 49.4 0.0 9.8e-13 48.1 0.0 1.8 1 0 0 1 1 1 1 U-box domain VWA PF00092.28 ELR17090.1 - 6.2e-09 36.3 0.0 3.4e-08 33.9 0.0 2.0 1 1 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.6 ELR17090.1 - 9.3e-07 29.5 0.0 2.8e-06 27.9 0.0 1.8 1 0 0 1 1 1 1 von Willebrand factor type A domain Rtf2 PF04641.12 ELR17090.1 - 6.2e-06 25.8 0.0 1.2e-05 24.8 0.0 1.4 1 0 0 1 1 1 1 Rtf2 RING-finger zf-Nse PF11789.8 ELR17090.1 - 1.4e-05 24.8 0.2 3e-05 23.7 0.2 1.5 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_UBOX PF13445.6 ELR17090.1 - 4e-05 23.5 2.9 0.00011 22.2 2.9 1.8 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_2 PF13639.6 ELR17090.1 - 0.00093 19.5 0.9 0.0018 18.5 0.9 1.5 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.7 ELR17090.1 - 0.0017 18.6 0.7 0.0036 17.6 0.7 1.5 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_4 PF15227.6 ELR17090.1 - 0.0018 18.4 0.1 0.0035 17.5 0.1 1.5 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-C3HC4_2 PF13923.6 ELR17090.1 - 0.002 17.9 0.3 0.005 16.7 0.3 1.7 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 ELR17090.1 - 0.034 14.2 0.3 0.063 13.3 0.3 1.4 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger Prok-RING_4 PF14447.6 ELR17090.1 - 0.04 13.8 0.3 0.083 12.8 0.3 1.5 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 Baculo_PEP_C PF04513.12 ELR17090.1 - 0.15 12.1 0.0 0.3 11.1 0.0 1.4 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus PPTA PF01239.22 ELR17090.1 - 0.2 11.5 0.2 0.42 10.4 0.2 1.6 1 0 0 1 1 1 0 Protein prenyltransferase alpha subunit repeat Senescence PF06911.12 ELR17091.1 - 2.6e-26 93.1 7.8 5.7e-26 92.0 7.8 1.5 1 0 0 1 1 1 1 Senescence-associated protein MIT PF04212.18 ELR17091.1 - 1.8e-10 40.7 0.9 4.2e-10 39.6 0.9 1.6 1 0 0 1 1 1 1 MIT (microtubule interacting and transport) domain Inp1 PF12634.7 ELR17091.1 - 0.0056 16.7 0.1 0.015 15.4 0.0 1.7 2 0 0 2 2 2 1 Inheritance of peroxisomes protein 1 TPR_7 PF13176.6 ELR17091.1 - 0.054 13.6 0.4 0.15 12.1 0.4 1.8 1 0 0 1 1 1 0 Tetratricopeptide repeat GOLD_2 PF13897.6 ELR17091.1 - 0.26 11.8 6.3 7.3 7.1 3.0 2.6 2 0 0 2 2 2 0 Golgi-dynamics membrane-trafficking SKIP_SNW PF02731.15 ELR17091.1 - 2.7 7.6 8.7 1 9.0 0.0 2.5 2 0 0 2 2 2 0 SKIP/SNW domain DUF501 PF04417.12 ELR17091.1 - 4.2 7.2 6.4 1 9.1 1.2 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF501) FA_desaturase PF00487.24 ELR17092.1 - 8.8e-29 101.1 26.8 1.2e-28 100.6 22.5 2.2 1 1 1 2 2 2 2 Fatty acid desaturase Cyt-b5 PF00173.28 ELR17092.1 - 3.1e-23 81.7 0.0 6.5e-23 80.7 0.0 1.6 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Multi_Drug_Res PF00893.19 ELR17092.1 - 0.0023 18.6 0.5 0.0057 17.3 0.5 1.6 1 0 0 1 1 1 1 Small Multidrug Resistance protein Peptidase_S8 PF00082.22 ELR17094.1 - 3.8e-35 121.6 2.3 5.2e-35 121.1 2.3 1.2 1 0 0 1 1 1 1 Subtilase family P_proprotein PF01483.20 ELR17094.1 - 1.1e-22 79.8 0.3 2.6e-22 78.7 0.3 1.6 1 0 0 1 1 1 1 Proprotein convertase P-domain S8_pro-domain PF16470.5 ELR17094.1 - 4e-15 56.3 0.6 7.4e-15 55.5 0.6 1.5 1 0 0 1 1 1 1 Peptidase S8 pro-domain F-box-like PF12937.7 ELR17095.1 - 0.00033 20.5 4.6 0.00033 20.5 4.6 1.9 2 0 0 2 2 2 1 F-box-like SMAP PF15477.6 ELR17096.1 - 3.3e-12 47.2 0.0 3.3e-12 47.2 0.0 4.4 2 1 0 2 2 2 1 Small acidic protein family AF-4 PF05110.13 ELR17096.1 - 0.19 9.8 46.3 0.22 9.6 46.3 1.2 1 0 0 1 1 1 0 AF-4 proto-oncoprotein N6-adenineMlase PF10237.9 ELR17097.1 - 1.4e-46 158.2 0.0 1.7e-46 157.9 0.0 1.1 1 0 0 1 1 1 1 Probable N6-adenine methyltransferase WSD PF15613.6 ELR17097.1 - 0.0045 17.4 0.0 0.0094 16.4 0.0 1.6 1 0 0 1 1 1 1 Williams-Beuren syndrome DDT (WSD), D-TOX E motif Cons_hypoth95 PF03602.15 ELR17097.1 - 0.011 15.4 0.0 0.033 13.8 0.0 1.7 1 1 1 2 2 2 0 Conserved hypothetical protein 95 PseudoU_synth_2 PF00849.22 ELR17098.1 - 5.1e-13 49.4 0.0 1.3e-12 48.1 0.0 1.8 1 1 0 1 1 1 1 RNA pseudouridylate synthase PPP4R2 PF09184.11 ELR17098.1 - 1.9 8.0 10.5 2.8 7.4 10.5 1.2 1 0 0 1 1 1 0 PPP4R2 Presenilin PF01080.17 ELR17098.1 - 2 7.1 3.3 2.9 6.5 3.3 1.3 1 0 0 1 1 1 0 Presenilin RR_TM4-6 PF06459.12 ELR17098.1 - 2.5 7.8 9.1 4 7.2 9.1 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 CDC45 PF02724.14 ELR17098.1 - 3.4 5.8 10.5 5 5.3 10.5 1.2 1 0 0 1 1 1 0 CDC45-like protein Dicty_REP PF05086.12 ELR17098.1 - 5.5 4.8 5.2 7 4.5 5.2 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein DUF4778 PF16008.5 ELR17098.1 - 5.9 6.9 7.2 45 4.0 8.0 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4778) WD40 PF00400.32 ELR17100.1 - 5.4e-15 55.5 3.4 3.5e-06 27.6 0.0 4.0 4 0 0 4 4 4 2 WD domain, G-beta repeat Peptidase_S24 PF00717.23 ELR17101.1 - 3.3e-05 23.8 0.0 0.0001 22.2 0.0 1.8 1 1 0 1 1 1 1 Peptidase S24-like Peptidase_S26 PF10502.9 ELR17101.1 - 4.6e-05 23.2 0.0 0.00087 19.1 0.0 2.4 1 1 0 1 1 1 1 Signal peptidase, peptidase S26 LSM PF01423.22 ELR17104.1 - 2.3e-09 36.8 0.1 3.6e-09 36.2 0.1 1.3 1 0 0 1 1 1 1 LSM domain DZR PF12773.7 ELR17104.1 - 0.0022 17.9 1.1 0.005 16.8 1.1 1.6 1 0 0 1 1 1 1 Double zinc ribbon NOB1_Zn_bind PF08772.11 ELR17104.1 - 0.0085 16.2 1.0 0.016 15.3 1.0 1.4 1 0 0 1 1 1 1 Nin one binding (NOB1) Zn-ribbon like DUF2121 PF09894.9 ELR17104.1 - 0.033 13.7 0.2 0.046 13.3 0.2 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2121) zinc_ribbon_15 PF17032.5 ELR17104.1 - 0.094 13.5 0.8 0.094 13.5 0.8 1.9 3 0 0 3 3 3 0 zinc-ribbon family PLATZ PF04640.14 ELR17104.1 - 0.11 13.1 0.2 0.11 13.1 0.2 1.8 2 0 0 2 2 2 0 PLATZ transcription factor LRR_4 PF12799.7 ELR17105.1 - 1.1e-06 28.9 19.6 0.2 12.1 0.2 6.0 2 2 2 5 5 5 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 ELR17105.1 - 0.00059 19.6 23.5 0.023 14.5 1.7 4.8 2 2 2 4 4 4 3 Leucine rich repeat DUF2267 PF10025.9 ELR17106.1 - 4.9e-18 65.6 0.0 6.1e-18 65.3 0.0 1.1 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2267) FRB_dom PF08771.11 ELR17106.1 - 0.023 15.1 0.0 0.041 14.3 0.0 1.4 1 0 0 1 1 1 0 FKBP12-rapamycin binding domain AAA PF00004.29 ELR17107.1 - 3.2e-18 66.4 0.0 1.6e-17 64.2 0.0 2.1 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 ELR17107.1 - 6.5e-05 23.2 1.6 0.0041 17.4 0.1 3.3 2 1 1 3 3 3 1 AAA domain AAA_16 PF13191.6 ELR17107.1 - 0.00014 22.3 0.4 0.0007 20.0 0.4 2.3 1 1 0 1 1 1 1 AAA ATPase domain AAA_5 PF07728.14 ELR17107.1 - 0.00066 19.7 0.0 0.0015 18.5 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) Par3_HAL_N_term PF12053.8 ELR17107.1 - 0.0056 16.9 0.0 0.018 15.2 0.0 1.9 1 0 0 1 1 1 1 N-terminal of Par3 and HAL proteins Zot PF05707.12 ELR17107.1 - 0.0082 15.8 0.1 0.3 10.7 0.0 2.5 1 1 0 2 2 2 1 Zonular occludens toxin (Zot) AAA_2 PF07724.14 ELR17107.1 - 0.013 15.6 0.0 0.04 14.0 0.0 1.8 1 0 0 1 1 1 0 AAA domain (Cdc48 subfamily) Vps36_ESCRT-II PF11605.8 ELR17107.1 - 0.02 15.1 0.0 0.063 13.5 0.0 1.8 1 0 0 1 1 1 0 Vacuolar protein sorting protein 36 Vps36 AAA_11 PF13086.6 ELR17107.1 - 0.04 13.7 0.2 0.28 11.0 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_18 PF13238.6 ELR17107.1 - 0.06 13.9 0.0 0.37 11.3 0.0 2.3 2 0 0 2 2 2 0 AAA domain Mg_chelatase PF01078.21 ELR17107.1 - 0.077 12.4 0.1 0.16 11.3 0.1 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI RuvB_N PF05496.12 ELR17107.1 - 0.13 12.0 0.0 0.25 11.1 0.0 1.4 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain MCM_lid PF17855.1 ELR17107.1 - 0.17 12.3 0.1 0.4 11.1 0.1 1.6 1 0 0 1 1 1 0 MCM AAA-lid domain Ribosomal_60s PF00428.19 ELR17107.1 - 8.1 7.1 10.5 3 8.5 6.9 2.2 2 0 0 2 2 1 0 60s Acidic ribosomal protein zf-C3Hc3H PF13891.6 ELR17108.1 - 2.6e-26 91.7 12.3 2.4e-13 50.2 2.2 2.4 2 0 0 2 2 2 2 Potential DNA-binding domain WRC PF08879.10 ELR17108.1 - 0.044 13.5 3.9 37 4.1 0.1 4.2 4 0 0 4 4 4 0 WRC Methyltransf_11 PF08241.12 ELR17109.1 - 2.9e-13 50.3 0.0 6.7e-13 49.1 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 ELR17109.1 - 2.1e-11 43.9 0.0 3.3e-11 43.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ELR17109.1 - 5.3e-08 33.5 0.0 1.4e-07 32.2 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ELR17109.1 - 2.2e-07 31.5 0.1 5.8e-07 30.2 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 ELR17109.1 - 4.9e-07 29.7 0.0 8.8e-07 28.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 ELR17109.1 - 1.3e-05 24.6 0.0 2.5e-05 23.7 0.0 1.4 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family DUF4202 PF13875.6 ELR17109.1 - 0.0026 17.7 0.7 0.25 11.2 0.0 2.1 2 0 0 2 2 2 2 Domain of unknown function (DUF4202) Methyltransf_8 PF05148.15 ELR17109.1 - 0.005 16.7 0.0 0.0081 16.0 0.0 1.2 1 0 0 1 1 1 1 Hypothetical methyltransferase ECH_1 PF00378.20 ELR17110.1 - 5.8e-33 114.2 0.1 7.6e-33 113.9 0.1 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 ELR17110.1 - 2.5e-17 63.4 0.0 3.1e-17 63.1 0.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase PI_PP_C PF18365.1 ELR17110.1 - 0.0076 16.2 0.0 0.012 15.6 0.0 1.3 1 0 0 1 1 1 1 Phosphoinositide phosphatase C-terminal domain DUF3291 PF11695.8 ELR17110.1 - 0.056 13.1 0.0 0.077 12.7 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3291) Importin_rep_4 PF18808.1 ELR17110.1 - 0.12 12.7 0.3 0.21 11.9 0.1 1.5 1 1 0 1 1 1 0 Importin repeat Beta-lactamase PF00144.24 ELR17110.1 - 0.14 11.4 0.0 0.19 10.9 0.0 1.1 1 0 0 1 1 1 0 Beta-lactamase RNA_pol_3_Rpc31 PF11705.8 ELR17111.1 - 0.46 10.7 37.9 0.031 14.5 12.8 3.5 3 0 0 3 3 3 0 DNA-directed RNA polymerase III subunit Rpc31 CDC45 PF02724.14 ELR17111.1 - 0.49 8.6 29.8 0.023 13.0 3.2 3.1 3 0 0 3 3 3 0 CDC45-like protein Nop14 PF04147.12 ELR17111.1 - 2.4 6.3 38.5 0.1 10.8 11.1 2.9 3 0 0 3 3 3 0 Nop14-like family TFIIA PF03153.13 ELR17111.1 - 2.9 7.8 33.1 0.017 15.2 11.0 2.9 3 0 0 3 3 3 0 Transcription factor IIA, alpha/beta subunit BSP_II PF05432.11 ELR17112.1 - 0.058 13.1 4.9 1.2 8.8 1.8 2.2 2 0 0 2 2 2 0 Bone sialoprotein II (BSP-II) Peptidase_M14 PF00246.24 ELR17113.1 - 1.3e-87 294.3 0.8 1.5e-87 294.0 0.8 1.1 1 0 0 1 1 1 1 Zinc carboxypeptidase DIM PF08194.12 ELR17113.1 - 0.16 12.2 3.6 5.1 7.4 0.1 2.5 2 0 0 2 2 2 0 DIM protein Spo12 PF05032.12 ELR17114.1 - 3.5e-06 26.8 0.2 7.7e-06 25.7 0.2 1.7 1 0 0 1 1 1 1 Spo12 family DUF1084 PF06454.11 ELR17115.1 - 2.1e-20 73.2 18.4 2.5e-20 73.0 18.4 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1084) DUF202 PF02656.15 ELR17115.1 - 0.2 12.1 0.2 0.2 12.1 0.2 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF202) Sdh_cyt PF01127.22 ELR17115.1 - 2 8.4 10.2 0.94 9.5 5.0 2.8 1 1 2 3 3 3 0 Succinate dehydrogenase/Fumarate reductase transmembrane subunit NTP_transf_2 PF01909.23 ELR17116.1 - 0.00011 22.4 0.0 0.00026 21.2 0.0 1.6 1 0 0 1 1 1 1 Nucleotidyltransferase domain Polbeta PF18765.1 ELR17116.1 - 0.00016 21.7 0.0 0.00045 20.2 0.0 1.7 1 0 0 1 1 1 1 Polymerase beta, Nucleotidyltransferase RNA_lig_T4_1 PF09511.10 ELR17116.1 - 0.0031 17.4 0.0 0.016 15.1 0.0 2.2 2 1 0 2 2 2 1 RNA ligase SUIM_assoc PF16619.5 ELR17116.1 - 0.2 11.8 11.3 0.045 13.8 4.5 3.2 3 1 0 3 3 3 0 Unstructured region C-term to UIM in Ataxin3 PTEN_C2 PF10409.9 ELR17117.1 - 1e-15 57.7 0.2 1.6e-15 57.1 0.2 1.3 1 0 0 1 1 1 1 C2 domain of PTEN tumour-suppressor protein DSPc PF00782.20 ELR17117.1 - 2.1e-06 27.6 0.1 3.8e-06 26.7 0.1 1.6 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 ELR17117.1 - 0.0017 18.3 0.0 0.003 17.6 0.0 1.3 1 0 0 1 1 1 1 Tyrosine phosphatase family PTPlike_phytase PF14566.6 ELR17117.1 - 0.068 13.3 0.0 0.15 12.2 0.0 1.6 1 0 0 1 1 1 0 Inositol hexakisphosphate Y_phosphatase PF00102.27 ELR17117.1 - 0.079 12.5 0.2 0.14 11.7 0.0 1.5 2 0 0 2 2 2 0 Protein-tyrosine phosphatase CDC45 PF02724.14 ELR17117.1 - 7.3 4.8 8.3 9.4 4.4 8.3 1.1 1 0 0 1 1 1 0 CDC45-like protein U-box PF04564.15 ELR17118.1 - 2.1e-15 56.7 0.0 3.1e-15 56.1 0.0 1.3 1 0 0 1 1 1 1 U-box domain zf-Nse PF11789.8 ELR17118.1 - 2e-06 27.5 0.4 4.7e-06 26.3 0.4 1.6 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-rbx1 PF12678.7 ELR17118.1 - 3.9e-05 23.8 0.2 3.9e-05 23.8 0.2 2.3 2 1 0 2 2 2 1 RING-H2 zinc finger domain zf-RING_2 PF13639.6 ELR17118.1 - 0.00013 22.2 0.3 0.00013 22.2 0.3 2.9 2 1 0 2 2 2 1 Ring finger domain Rad50_zn_hook PF04423.14 ELR17118.1 - 0.0084 15.9 0.3 0.0084 15.9 0.3 2.2 2 0 0 2 2 2 1 Rad50 zinc hook motif Ras PF00071.22 ELR17119.1 - 7.6e-27 93.9 0.0 1.2e-26 93.3 0.0 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR17119.1 - 2.2e-09 37.6 0.0 3.5e-09 36.9 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Aquarius_N PF16399.5 ELR17120.1 - 0.028 12.5 0.2 0.037 12.1 0.2 1.0 1 0 0 1 1 1 0 Intron-binding protein aquarius N-terminus DDOST_48kD PF03345.14 ELR17121.1 - 0.059 12.2 0.9 0.082 11.7 0.9 1.1 1 0 0 1 1 1 0 Oligosaccharyltransferase 48 kDa subunit beta P120R PF08062.11 ELR17121.1 - 0.9 10.0 5.4 0.16 12.4 1.1 2.0 2 0 0 2 2 2 0 P120R (NUC006) repeat MyTH4 PF00784.17 ELR17121.1 - 1.3 9.6 8.0 0.23 12.0 1.4 2.3 2 0 0 2 2 2 0 MyTH4 domain Proteasome PF00227.26 ELR17123.1 - 2.7e-36 124.9 0.0 3.1e-36 124.6 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit bZIP_1 PF00170.21 ELR17124.1 - 8.1e-12 45.1 6.6 8.1e-12 45.1 6.6 2.1 2 0 0 2 2 2 1 bZIP transcription factor bZIP_2 PF07716.15 ELR17124.1 - 7.3e-10 38.8 4.5 7.3e-10 38.8 4.5 2.5 2 0 0 2 2 2 1 Basic region leucine zipper bZIP_Maf PF03131.17 ELR17124.1 - 0.0013 19.2 4.9 0.0013 19.2 4.9 2.4 2 0 0 2 2 2 1 bZIP Maf transcription factor CtIP_N PF10482.9 ELR17124.1 - 1.1 9.3 7.9 0.14 12.2 0.6 2.2 2 0 0 2 2 2 0 Tumour-suppressor protein CtIP N-terminal domain YabA PF06156.13 ELR17124.1 - 6.2 7.5 6.3 1.7 9.4 0.4 2.2 2 0 0 2 2 2 0 Initiation control protein YabA Ras PF00071.22 ELR17125.1 - 2.5e-50 170.2 0.0 3.3e-50 169.8 0.0 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR17125.1 - 7.1e-27 94.0 0.0 1.1e-26 93.4 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ank_2 PF12796.7 ELR17125.1 - 9e-19 67.9 0.2 4e-15 56.2 0.1 3.1 4 0 0 4 4 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ELR17125.1 - 1.2e-16 60.9 2.1 4.3e-12 46.3 0.6 4.0 2 1 2 4 4 4 2 Ankyrin repeats (many copies) Ank PF00023.30 ELR17125.1 - 8.8e-16 57.6 2.3 1.9e-07 31.2 0.2 5.1 5 0 0 5 5 5 3 Ankyrin repeat Ank_5 PF13857.6 ELR17125.1 - 2.1e-12 47.0 4.0 1.3e-08 34.9 0.8 4.7 3 1 2 5 5 5 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 ELR17125.1 - 3.9e-12 45.2 0.8 0.00017 21.8 0.0 4.9 5 0 0 5 5 5 2 Ankyrin repeat F-box-like PF12937.7 ELR17125.1 - 2.3e-09 37.0 0.3 4.6e-09 36.0 0.3 1.5 1 0 0 1 1 1 1 F-box-like Arf PF00025.21 ELR17125.1 - 2.3e-08 33.7 0.0 4e-08 32.9 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 ELR17125.1 - 0.003 17.5 0.0 1.3 9.0 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase F-box PF00646.33 ELR17125.1 - 0.0053 16.6 0.1 0.0094 15.8 0.1 1.4 1 0 0 1 1 1 1 F-box domain VirE PF05272.11 ELR17125.1 - 0.0062 16.3 0.0 0.048 13.4 0.0 2.0 2 0 0 2 2 2 1 Virulence-associated protein E MMR_HSR1 PF01926.23 ELR17125.1 - 0.03 14.4 0.0 0.054 13.6 0.0 1.4 1 0 0 1 1 1 0 50S ribosome-binding GTPase F-box_4 PF15966.5 ELR17125.1 - 0.057 13.3 0.0 0.11 12.4 0.0 1.4 1 0 0 1 1 1 0 F-box AAA_16 PF13191.6 ELR17125.1 - 0.15 12.4 0.0 0.36 11.2 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain DSPc PF00782.20 ELR17126.1 - 7.2e-33 113.2 0.0 9.6e-33 112.8 0.0 1.2 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.6 ELR17126.1 - 0.00023 21.3 0.1 0.00033 20.8 0.1 1.2 1 0 0 1 1 1 1 Inositol hexakisphosphate Y_phosphatase PF00102.27 ELR17126.1 - 0.0037 16.9 0.0 0.0048 16.5 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase2 PF03162.13 ELR17126.1 - 0.041 13.5 0.1 0.12 11.9 0.1 1.7 1 1 0 1 1 1 0 Tyrosine phosphatase family Rhodanese PF00581.20 ELR17126.1 - 0.05 14.1 0.0 2.8 8.5 0.0 2.9 2 1 0 2 2 2 0 Rhodanese-like domain HSCB_C PF07743.13 ELR17127.1 - 3.8e-20 72.2 5.9 6.4e-20 71.4 4.3 1.9 2 0 0 2 2 2 1 HSCB C-terminal oligomerisation domain DnaJ PF00226.31 ELR17127.1 - 8.9e-07 29.0 0.1 1.8e-06 27.9 0.1 1.5 1 0 0 1 1 1 1 DnaJ domain Salt_tol_Pase PF09506.10 ELR17127.1 - 0.023 13.5 0.0 0.029 13.1 0.0 1.1 1 0 0 1 1 1 0 Glucosylglycerol-phosphate phosphatase (Salt_tol_Pase) DUF1340 PF07067.11 ELR17127.1 - 0.09 12.1 0.3 0.18 11.2 0.0 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1340) zf-ribbon_3 PF13248.6 ELR17127.1 - 8.6 5.9 11.7 2.5 7.6 0.4 2.7 2 0 0 2 2 2 0 zinc-ribbon domain SNF2_N PF00176.23 ELR17128.1 - 2.2e-27 95.7 0.1 3.5e-27 95.0 0.1 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 ELR17128.1 - 7e-13 48.9 0.0 2.5e-12 47.1 0.0 2.0 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 ELR17128.1 - 2.1e-09 37.6 0.0 7.5e-09 35.8 0.0 1.9 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit HARP PF07443.13 ELR17128.1 - 0.0051 16.4 0.0 0.013 15.2 0.0 1.6 1 0 0 1 1 1 1 HepA-related protein (HARP) DUF4407 PF14362.6 ELR17129.1 - 0.77 9.1 4.1 1.3 8.3 4.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Abhydrolase_1 PF00561.20 ELR17130.1 - 1.2e-09 38.2 0.0 2.3e-09 37.3 0.0 1.5 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 ELR17130.1 - 2.8e-07 31.4 6.3 2.8e-07 31.4 6.3 2.3 1 1 0 2 2 2 1 Alpha/beta hydrolase family GST_C_2 PF13410.6 ELR17130.1 - 0.037 14.1 0.9 0.099 12.7 0.1 2.1 2 0 0 2 2 2 0 Glutathione S-transferase, C-terminal domain F-box-like PF12937.7 ELR17131.1 - 0.39 10.7 3.3 0.16 11.9 0.5 1.7 2 0 0 2 2 2 0 F-box-like FAM176 PF14851.6 ELR17131.1 - 0.99 9.1 3.0 1.9 8.1 3.0 1.4 1 0 0 1 1 1 0 FAM176 family Nucleo_P87 PF07267.11 ELR17131.1 - 9.7 4.9 5.3 14 4.4 5.3 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 Pinin_SDK_memA PF04696.13 ELR17133.1 - 0.01 15.9 8.1 0.01 15.9 8.1 2.4 2 0 0 2 2 2 0 pinin/SDK/memA/ protein conserved region D5_N PF08706.11 ELR17133.1 - 2.4 8.4 6.6 5.2 7.3 1.7 2.3 2 0 0 2 2 2 0 D5 N terminal like FKBP_N PF01346.18 ELR17133.1 - 5.4 8.0 7.4 3.7 8.6 2.7 2.4 2 0 0 2 2 2 0 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase Glyco_hydro_38N PF01074.22 ELR17138.1 - 3.4e-94 315.5 0.9 5.5e-94 314.8 0.9 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 N-terminal domain Glyco_hydro_38C PF07748.13 ELR17138.1 - 6.3e-39 134.3 0.1 1.4e-38 133.1 0.0 1.6 2 0 0 2 2 2 1 Glycosyl hydrolases family 38 C-terminal domain Alpha-mann_mid PF09261.11 ELR17138.1 - 1.8e-20 72.9 0.2 5.3e-20 71.4 0.1 1.9 2 0 0 2 2 2 1 Alpha mannosidase middle domain Glyco_hydro38C2 PF17677.1 ELR17138.1 - 5.2e-09 36.1 0.0 1.8e-08 34.4 0.0 2.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 C-terminal beta sandwich domain Far-17a_AIG1 PF04750.14 ELR17139.1 - 6.4e-19 68.1 17.6 1.1e-18 67.3 17.5 1.5 1 1 0 1 1 1 1 FAR-17a/AIG1-like protein Ank_2 PF12796.7 ELR17140.1 - 1.1e-57 192.5 9.6 6.8e-13 49.0 0.0 5.9 3 2 2 5 5 5 5 Ankyrin repeats (3 copies) BTB PF00651.31 ELR17140.1 - 2e-43 147.1 0.1 3e-17 62.9 0.1 6.2 5 2 0 5 5 5 4 BTB/POZ domain Ank PF00023.30 ELR17140.1 - 1.2e-41 139.4 24.3 2.3e-05 24.6 0.1 11.8 11 0 0 11 11 11 10 Ankyrin repeat Ank_5 PF13857.6 ELR17140.1 - 1.6e-41 139.8 14.8 3.7e-09 36.7 0.2 8.5 4 3 2 7 7 7 7 Ankyrin repeats (many copies) Ank_3 PF13606.6 ELR17140.1 - 4.1e-40 131.2 18.5 0.00035 20.8 0.1 13.6 13 1 0 13 13 13 9 Ankyrin repeat Ank_4 PF13637.6 ELR17140.1 - 9.3e-39 131.3 13.6 4.5e-06 27.1 0.0 10.4 5 5 5 10 10 10 9 Ankyrin repeats (many copies) Gpr1_Fun34_YaaH PF01184.19 ELR17141.1 - 1.1e-52 178.7 19.3 1.6e-52 178.2 19.3 1.1 1 0 0 1 1 1 1 GPR1/FUN34/yaaH family US30 PF17624.2 ELR17141.1 - 0.052 12.6 0.2 0.084 11.9 0.2 1.2 1 0 0 1 1 1 0 Family of unknown function zf-BED PF02892.15 ELR17143.1 - 0.0041 17.1 0.2 0.71 9.9 0.1 2.3 2 0 0 2 2 2 2 BED zinc finger zf-C2H2_jaz PF12171.8 ELR17143.1 - 6.2 7.2 5.5 86 3.6 0.0 3.0 2 1 0 2 2 2 0 Zinc-finger double-stranded RNA-binding adh_short PF00106.25 ELR17144.1 - 9.5e-18 64.4 0.0 5.6e-12 45.5 0.0 2.2 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 ELR17144.1 - 2.3e-08 33.9 0.0 8.6e-06 25.5 0.0 2.3 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ELR17144.1 - 0.045 13.7 0.1 0.081 12.8 0.1 1.4 1 1 0 1 1 1 0 KR domain WD40 PF00400.32 ELR17145.1 - 7.6e-13 48.7 5.1 3.8e-05 24.3 0.7 3.8 3 0 0 3 3 3 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ELR17145.1 - 0.00017 21.8 0.1 1.1 9.6 0.0 3.8 2 1 3 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain FA_hydroxylase PF04116.13 ELR17146.1 - 1.4e-28 99.9 18.9 1.4e-28 99.9 18.9 2.0 2 0 0 2 2 2 1 Fatty acid hydroxylase superfamily Erf4 PF10256.9 ELR17147.1 - 5e-27 94.3 0.0 6.5e-27 93.9 0.0 1.0 1 0 0 1 1 1 1 Golgin subfamily A member 7/ERF4 family PNKP_ligase PF16542.5 ELR17149.1 - 2.8e-40 138.8 0.0 3.6e-38 131.9 0.0 2.5 1 1 0 1 1 1 1 PNKP adenylyltransferase domain, ligase domain Methyltransf_23 PF13489.6 ELR17149.1 - 0.0063 16.4 0.0 0.013 15.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ELR17149.1 - 0.01 15.6 0.0 0.12 12.1 0.0 2.5 2 1 0 2 2 2 0 Methyltransferase domain Myc_N PF01056.18 ELR17149.1 - 0.02 14.8 4.1 0.032 14.1 4.1 1.2 1 0 0 1 1 1 0 Myc amino-terminal region Methyltransf_25 PF13649.6 ELR17149.1 - 0.12 13.0 0.0 0.35 11.6 0.0 1.9 1 0 0 1 1 1 0 Methyltransferase domain MTS PF05175.14 ELR17149.1 - 0.2 11.2 0.0 0.43 10.1 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_32 PF13679.6 ELR17149.1 - 0.23 11.5 0.4 0.52 10.3 0.0 1.8 2 0 0 2 2 2 0 Methyltransferase domain RNA_pol_3_Rpc31 PF11705.8 ELR17149.1 - 0.88 9.8 15.6 1.5 9.0 15.6 1.3 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 Spore_coat_CotO PF14153.6 ELR17149.1 - 3.2 7.6 10.8 6.6 6.6 10.8 1.4 1 0 0 1 1 1 0 Spore coat protein CotO CDC27 PF09507.10 ELR17149.1 - 3.9 6.8 17.5 6 6.1 17.5 1.2 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Pkinase PF00069.25 ELR17150.1 - 3e-78 262.8 0.0 7.7e-78 261.5 0.0 1.7 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR17150.1 - 3.6e-54 183.8 0.0 6.3e-54 183.0 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 ELR17150.1 - 7.2e-06 25.0 0.0 7.2e-06 25.0 0.0 2.6 2 1 0 2 2 2 1 Fungal protein kinase Kinase-like PF14531.6 ELR17150.1 - 0.00064 19.1 0.1 0.023 14.0 0.0 2.5 3 0 0 3 3 3 1 Kinase-like CAF-1_p150 PF11600.8 ELR17150.1 - 0.00086 19.0 11.4 0.00086 19.0 11.4 2.4 2 0 0 2 2 2 1 Chromatin assembly factor 1 complex p150 subunit, N-terminal Takusan PF04822.13 ELR17150.1 - 0.018 14.9 3.1 0.018 14.9 3.1 2.4 2 1 0 3 3 3 0 Takusan FTA2 PF13095.6 ELR17150.1 - 0.22 11.1 1.3 3.2 7.3 0.0 2.4 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 MFS_1 PF07690.16 ELR17151.1 - 8.7e-25 87.4 42.9 8.7e-25 87.4 42.9 1.7 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 ELR17151.1 - 0.00016 20.7 7.1 0.00016 20.7 7.1 2.6 2 1 0 2 2 2 1 Sugar (and other) transporter MFS_4 PF06779.14 ELR17151.1 - 0.003 16.9 35.5 0.0038 16.6 35.5 1.1 1 0 0 1 1 1 1 Uncharacterised MFS-type transporter YbfB Shugoshin_C PF07557.11 ELR17152.1 - 1.8e-05 24.4 1.3 8.2e-05 22.3 1.3 2.2 1 0 0 1 1 1 1 Shugoshin C terminus zf-CCCH PF00642.24 ELR17153.1 - 3.9e-10 39.4 3.2 1.1e-09 38.0 3.2 1.8 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-RING_UBOX PF13445.6 ELR17153.1 - 1.1e-06 28.5 5.4 2.9e-06 27.2 5.4 1.8 1 1 0 1 1 1 1 RING-type zinc-finger zf_CCCH_4 PF18345.1 ELR17153.1 - 2.3e-05 24.3 5.1 2.3e-05 24.3 5.1 1.9 2 0 0 2 2 1 1 Zinc finger domain zf-C3HC4_3 PF13920.6 ELR17153.1 - 0.00014 21.7 10.1 0.00027 20.7 10.1 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ELR17153.1 - 0.00036 20.4 15.0 0.00066 19.6 15.0 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_4 PF15227.6 ELR17153.1 - 0.001 19.2 11.0 0.0029 17.7 11.0 1.8 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-C3HC4_2 PF13923.6 ELR17153.1 - 0.001 18.8 13.4 0.0025 17.6 13.4 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-CCCH_4 PF18044.1 ELR17153.1 - 0.0035 17.1 3.2 0.0035 17.1 3.2 2.3 2 0 0 2 2 2 1 CCCH-type zinc finger Prok-RING_4 PF14447.6 ELR17153.1 - 0.012 15.4 9.3 0.023 14.6 9.3 1.4 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-RING_10 PF16685.5 ELR17153.1 - 0.016 15.3 7.3 0.016 15.3 7.3 1.7 2 0 0 2 2 1 0 zinc RING finger of MSL2 zf-CCCH_2 PF14608.6 ELR17153.1 - 0.019 15.4 2.4 0.051 14.1 2.4 1.8 1 0 0 1 1 1 0 RNA-binding, Nab2-type zinc finger zf-RING_2 PF13639.6 ELR17153.1 - 0.026 14.8 12.6 0.026 14.8 12.6 1.7 2 0 0 2 2 2 0 Ring finger domain zf-C3HC4 PF00097.25 ELR17153.1 - 0.042 13.7 13.7 0.097 12.6 13.7 1.7 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Siva PF05458.12 ELR17153.1 - 0.097 12.4 5.6 0.12 12.0 4.0 1.9 2 0 0 2 2 2 0 Cd27 binding protein (Siva) zf-Nse PF11789.8 ELR17153.1 - 1 9.3 5.9 2 8.3 5.9 1.5 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit E1-E2_ATPase PF00122.20 ELR17154.1 - 2.2e-46 157.7 1.3 2.2e-46 157.7 1.3 2.5 2 1 1 3 3 3 1 E1-E2 ATPase Hydrolase PF00702.26 ELR17154.1 - 1.1e-40 140.2 8.4 3.4e-38 132.1 8.0 3.3 2 2 0 2 2 2 1 haloacid dehalogenase-like hydrolase HMA PF00403.26 ELR17154.1 - 1.3e-07 32.0 1.4 0.015 15.7 0.5 3.3 2 1 0 2 2 2 2 Heavy-metal-associated domain HAD PF12710.7 ELR17154.1 - 5e-06 27.0 3.7 5.5e-05 23.7 1.5 3.0 1 1 0 2 2 2 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 ELR17154.1 - 1.8e-05 24.6 1.0 0.023 14.4 0.5 2.4 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase DUF1529 PF07485.11 ELR17154.1 - 0.2 11.5 2.0 20 5.1 0.1 3.7 4 0 0 4 4 4 0 Domain of Unknown Function (DUF1259) CytB6-F_Fe-S PF08802.10 ELR17154.1 - 0.46 10.6 3.7 2 8.5 3.7 2.2 1 0 0 1 1 1 0 Cytochrome B6-F complex Fe-S subunit 3HCDH_RFF PF18321.1 ELR17154.1 - 0.75 10.3 4.0 16 6.0 0.8 3.5 3 0 0 3 3 3 0 3-hydroxybutyryl-CoA dehydrogenase reduced Rossmann-fold domain Spectrin PF00435.21 ELR17157.1 - 0.068 13.7 4.0 4.3 7.9 0.0 2.6 2 1 1 3 3 3 0 Spectrin repeat Seryl_tRNA_N PF02403.22 ELR17157.1 - 0.091 13.0 1.4 9.2 6.6 0.1 2.2 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain ZapB PF06005.12 ELR17157.1 - 0.26 11.7 5.2 0.5 10.9 2.8 2.4 2 1 0 2 2 2 0 Cell division protein ZapB FUSC PF04632.12 ELR17157.1 - 0.41 9.1 4.6 0.48 8.9 4.6 1.0 1 0 0 1 1 1 0 Fusaric acid resistance protein family ABC_tran_CTD PF16326.5 ELR17157.1 - 1.1 9.6 7.4 1.7 8.9 3.8 2.2 1 1 1 2 2 2 0 ABC transporter C-terminal domain DUF1192 PF06698.11 ELR17157.1 - 1.7 8.8 6.4 0.44 10.6 1.1 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1192) RRP36 PF06102.12 ELR17158.1 - 1.2e-42 145.8 19.8 1.2e-42 145.8 19.8 2.3 1 1 1 2 2 2 1 rRNA biogenesis protein RRP36 CCM2_C PF16545.5 ELR17158.1 - 0.06 13.9 1.0 0.11 13.0 1.0 1.4 1 0 0 1 1 1 0 Cerebral cavernous malformation protein, harmonin-homology adh_short_C2 PF13561.6 ELR17159.1 - 7.3e-63 212.3 0.4 8.6e-63 212.0 0.4 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 ELR17159.1 - 4.2e-47 160.1 0.1 6.6e-47 159.5 0.1 1.3 1 1 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 ELR17159.1 - 9.5e-07 28.9 0.2 1.5e-06 28.2 0.2 1.3 1 0 0 1 1 1 1 KR domain DUF1776 PF08643.10 ELR17159.1 - 8.8e-06 25.3 0.0 1.3e-05 24.8 0.0 1.2 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) Homeodomain PF00046.29 ELR17160.1 - 2.5e-17 62.5 0.7 3.6e-17 61.9 0.7 1.2 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 ELR17160.1 - 2.1e-05 24.3 0.1 3.9e-05 23.5 0.1 1.5 1 0 0 1 1 1 1 Homeobox KN domain YdaS_antitoxin PF15943.5 ELR17160.1 - 0.033 14.0 0.1 0.049 13.5 0.1 1.3 1 0 0 1 1 1 0 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT Homez PF11569.8 ELR17160.1 - 0.13 11.7 0.1 0.24 10.9 0.1 1.4 1 0 0 1 1 1 0 Homeodomain leucine-zipper encoding, Homez SET PF00856.28 ELR17161.1 - 6.1e-12 46.3 0.0 3.8e-11 43.7 0.0 2.2 1 1 0 1 1 1 1 SET domain zf-MYND PF01753.18 ELR17161.1 - 8.5e-10 38.6 14.7 1.8e-09 37.5 14.7 1.6 1 0 0 1 1 1 1 MYND finger zf-C6H2 PF15801.5 ELR17161.1 - 5.2 7.5 12.1 19 5.7 12.1 1.9 1 1 0 1 1 1 0 zf-MYND-like zinc finger, mRNA-binding Heliorhodopsin PF18761.1 ELR17162.1 - 1.1e-73 247.6 9.8 1.3e-73 247.3 9.8 1.1 1 0 0 1 1 1 1 Heliorhodopsin LRR_4 PF12799.7 ELR17163.1 - 1.7e-22 79.1 8.7 4.2e-06 27.0 0.1 5.2 4 1 1 5 5 5 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 ELR17163.1 - 4.6e-22 77.5 16.3 4.9e-07 29.4 0.9 4.3 3 1 2 5 5 5 4 Leucine rich repeat LRR_6 PF13516.6 ELR17163.1 - 4e-08 32.7 16.6 1.4 9.1 0.2 7.8 8 0 0 8 8 8 3 Leucine Rich repeat LRR_1 PF00560.33 ELR17163.1 - 2.7e-07 30.2 14.2 2.5 9.0 0.0 7.3 6 2 0 6 6 6 4 Leucine Rich Repeat BUD22 PF09073.10 ELR17163.1 - 0.71 9.1 15.4 1.1 8.5 15.4 1.2 1 0 0 1 1 1 0 BUD22 Methyltransf_11 PF08241.12 ELR17164.1 - 5.6e-18 65.4 0.0 1.1e-17 64.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ELR17164.1 - 5.5e-14 52.6 0.0 1.9e-13 50.9 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ELR17164.1 - 2.3e-09 37.9 0.0 1.2e-08 35.6 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ELR17164.1 - 1.5e-08 34.6 0.0 4.2e-08 33.1 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 ELR17164.1 - 4.2e-06 26.7 0.0 5.1e-06 26.4 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 ELR17164.1 - 0.011 15.1 0.0 0.02 14.2 0.0 1.3 1 1 0 1 1 1 0 ubiE/COQ5 methyltransferase family DUF938 PF06080.12 ELR17164.1 - 0.022 14.5 0.0 0.033 13.9 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF938) ADH_zinc_N PF00107.26 ELR17164.1 - 0.17 11.8 0.0 1.9 8.5 0.0 2.2 1 1 0 1 1 1 0 Zinc-binding dehydrogenase F-box PF00646.33 ELR17165.1 - 0.00012 21.8 0.3 0.00046 20.0 0.1 2.0 2 0 0 2 2 2 1 F-box domain F-box-like PF12937.7 ELR17165.1 - 0.0074 16.2 0.1 0.017 15.0 0.1 1.7 1 0 0 1 1 1 1 F-box-like Thioredox_DsbH PF03190.15 ELR17165.1 - 0.029 14.3 0.0 0.064 13.2 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function, DUF255 Thioredoxin_7 PF13899.6 ELR17165.1 - 0.033 14.4 0.1 0.24 11.6 0.1 2.3 2 1 0 2 2 2 0 Thioredoxin-like LRR_1 PF00560.33 ELR17165.1 - 0.29 11.9 4.3 11 7.0 0.1 4.9 5 1 0 5 5 5 0 Leucine Rich Repeat Kinocilin PF15033.6 ELR17166.1 - 0.15 11.7 0.9 2.7 7.7 0.2 2.3 1 1 1 2 2 2 0 Kinocilin protein SAP PF02037.27 ELR17167.1 - 0.013 15.2 0.9 0.026 14.3 0.9 1.5 1 0 0 1 1 1 0 SAP domain Serinc PF03348.15 ELR17167.1 - 0.46 9.3 2.2 0.97 8.3 2.2 1.4 1 0 0 1 1 1 0 Serine incorporator (Serinc) Ureide_permease PF07168.11 ELR17167.1 - 7.9 5.1 8.1 15 4.2 8.1 1.4 1 0 0 1 1 1 0 Ureide permease Mcl1_mid PF12341.8 ELR17168.1 - 5.7e-50 170.3 0.1 1.7e-47 162.2 0.1 3.2 2 1 0 2 2 2 1 Minichromosome loss protein, Mcl1, middle region WD40 PF00400.32 ELR17168.1 - 6.8e-24 83.7 3.7 1.4e-08 35.2 0.0 7.1 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ELR17168.1 - 3.7e-16 59.2 0.2 0.0038 17.5 0.0 6.7 3 2 4 7 7 7 5 Anaphase-promoting complex subunit 4 WD40 domain RNA_pol_3_Rpc31 PF11705.8 ELR17168.1 - 0.0042 17.4 12.9 0.0042 17.4 12.9 2.6 2 0 0 2 2 2 1 DNA-directed RNA polymerase III subunit Rpc31 BUD22 PF09073.10 ELR17168.1 - 0.014 14.8 49.7 0.29 10.4 28.9 2.1 2 0 0 2 2 2 0 BUD22 eIF2A PF08662.11 ELR17168.1 - 0.015 15.1 0.0 0.2 11.5 0.0 2.3 2 0 0 2 2 2 0 Eukaryotic translation initiation factor eIF2A GGDEF_2 PF17853.1 ELR17169.1 - 0.008 16.4 0.4 0.78 10.0 0.0 2.1 1 1 1 2 2 2 2 GGDEF-like domain ox_reductase_C PF08635.10 ELR17170.1 - 1.2e-19 70.4 0.0 1.6e-14 53.8 0.0 2.2 2 0 0 2 2 2 2 Putative oxidoreductase C terminal domain GFO_IDH_MocA PF01408.22 ELR17170.1 - 4.1e-17 63.1 0.0 1.2e-16 61.6 0.0 1.8 2 0 0 2 2 2 1 Oxidoreductase family, NAD-binding Rossmann fold FMN_red PF03358.15 ELR17170.1 - 0.035 13.8 0.1 0.077 12.7 0.1 1.5 1 0 0 1 1 1 0 NADPH-dependent FMN reductase U-box PF04564.15 ELR17171.1 - 2.9e-10 40.2 0.0 8.3e-10 38.7 0.0 1.6 2 0 0 2 2 2 1 U-box domain zf-Nse PF11789.8 ELR17171.1 - 9.9e-08 31.7 0.4 2.2e-07 30.6 0.4 1.6 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_2 PF13639.6 ELR17171.1 - 2.1e-06 27.9 0.6 2.1e-06 27.9 0.6 2.4 3 0 0 3 3 3 1 Ring finger domain zf-rbx1 PF12678.7 ELR17171.1 - 1.5e-05 25.2 0.2 1.5e-05 25.2 0.2 1.9 2 0 0 2 2 2 1 RING-H2 zinc finger domain zf-RING_UBOX PF13445.6 ELR17171.1 - 1.8e-05 24.6 0.2 0.00011 22.2 0.0 2.3 1 1 1 2 2 2 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 ELR17171.1 - 2e-05 24.4 2.1 2e-05 24.3 0.2 2.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 ELR17171.1 - 0.00028 20.9 0.1 0.00055 19.9 0.1 1.4 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4 PF00097.25 ELR17171.1 - 0.00049 19.9 0.1 0.0014 18.4 0.1 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ELR17171.1 - 0.0032 17.4 0.2 0.0097 15.9 0.2 1.9 1 0 0 1 1 1 1 zinc-RING finger domain Zn-ribbon_8 PF09723.10 ELR17171.1 - 0.021 14.9 0.1 0.055 13.6 0.1 1.7 1 0 0 1 1 1 0 Zinc ribbon domain zf-C3HC4_4 PF15227.6 ELR17171.1 - 0.047 13.8 0.1 0.047 13.8 0.1 2.0 2 0 0 2 2 2 0 zinc finger of C3HC4-type, RING OGFr_N PF04664.13 ELR17172.1 - 8.6e-47 159.4 0.6 1.9e-46 158.2 0.6 1.4 1 1 0 1 1 1 1 Opioid growth factor receptor (OGFr) conserved region KI67R PF08065.12 ELR17172.1 - 0.051 14.1 0.6 0.12 12.9 0.6 1.6 1 0 0 1 1 1 0 KI67R (NUC007) repeat DUF1090 PF06476.12 ELR17172.1 - 0.097 12.8 3.5 0.21 11.7 3.5 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1090) Glyco_transf_10 PF00852.19 ELR17173.1 - 1e-13 51.4 0.2 1.9e-13 50.5 0.0 1.4 2 0 0 2 2 2 1 Glycosyltransferase family 10 (fucosyltransferase) C-term RhoGEF PF00621.20 ELR17174.1 - 1.8e-41 142.4 0.7 3.8e-41 141.3 0.7 1.6 1 0 0 1 1 1 1 RhoGEF domain IQ_SEC7_PH PF16453.5 ELR17174.1 - 0.058 13.4 0.3 0.18 11.8 0.0 1.9 2 0 0 2 2 2 0 PH domain SPRY PF00622.28 ELR17175.1 - 2.5e-05 24.4 0.0 3.9e-05 23.8 0.0 1.4 1 0 0 1 1 1 1 SPRY domain Myco_19_kDa PF05481.12 ELR17175.1 - 0.11 12.8 0.1 0.25 11.6 0.1 1.6 2 0 0 2 2 2 0 Mycobacterium 19 kDa lipoprotein antigen Gpr1_Fun34_YaaH PF01184.19 ELR17176.1 - 1.6e-46 158.5 15.2 2.3e-46 158.1 15.2 1.1 1 0 0 1 1 1 1 GPR1/FUN34/yaaH family DBR1 PF05011.13 ELR17178.1 - 1.9e-22 80.2 0.1 6.6e-21 75.2 0.1 2.5 1 1 0 1 1 1 1 Lariat debranching enzyme, C-terminal domain Metallophos PF00149.28 ELR17178.1 - 2.8e-10 41.1 0.7 1.4e-09 38.8 0.2 2.2 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 ELR17178.1 - 0.00052 20.2 0.0 0.0011 19.2 0.0 1.6 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain LsmAD PF06741.13 ELR17179.1 - 7.4e-22 77.7 4.5 7.4e-22 77.7 4.5 3.5 4 0 0 4 4 4 1 LsmAD domain SM-ATX PF14438.6 ELR17179.1 - 5.3e-14 52.1 0.0 1e-13 51.2 0.0 1.5 1 0 0 1 1 1 1 Ataxin 2 SM domain PAM2 PF07145.15 ELR17179.1 - 0.051 13.3 4.7 0.065 12.9 0.6 3.3 3 0 0 3 3 3 0 Ataxin-2 C-terminal region Myb_DNA-binding PF00249.31 ELR17181.1 - 4e-11 42.9 0.3 1.6e-10 41.0 0.0 2.2 2 0 0 2 2 2 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 ELR17181.1 - 7.3e-05 22.9 0.0 0.00038 20.6 0.0 2.3 2 0 0 2 2 2 1 Myb-like DNA-binding domain DUF2922 PF11148.8 ELR17183.1 - 0.17 11.6 0.7 0.85 9.4 0.1 2.2 3 0 0 3 3 3 0 Protein of unknown function (DUF2922) F-box-like PF12937.7 ELR17186.1 - 2.1e-12 46.7 0.3 4.6e-12 45.6 0.3 1.6 1 0 0 1 1 1 1 F-box-like Arrestin_N PF00339.29 ELR17186.1 - 2.6e-07 30.8 0.0 7.2e-07 29.4 0.0 1.7 2 0 0 2 2 2 1 Arrestin (or S-antigen), N-terminal domain F-box PF00646.33 ELR17186.1 - 1.9e-05 24.4 0.2 3.8e-05 23.4 0.2 1.5 1 0 0 1 1 1 1 F-box domain Arrestin_C PF02752.22 ELR17186.1 - 0.00034 21.1 0.0 0.0024 18.3 0.0 2.3 2 1 0 2 2 2 1 Arrestin (or S-antigen), C-terminal domain NAM PF02365.15 ELR17186.1 - 0.63 11.0 3.4 1.1 10.2 0.2 2.8 3 1 0 3 3 3 0 No apical meristem (NAM) protein SnoaL_2 PF12680.7 ELR17187.1 - 9.2e-05 23.0 0.1 0.00013 22.5 0.1 1.3 1 0 0 1 1 1 1 SnoaL-like domain F-box-like PF12937.7 ELR17188.1 - 4.5e-12 45.7 0.1 8.3e-12 44.8 0.1 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ELR17188.1 - 1.3e-06 28.2 0.1 2.3e-06 27.3 0.1 1.4 1 0 0 1 1 1 1 F-box domain SPRY PF00622.28 ELR17188.1 - 2.6e-06 27.5 0.2 2.5e-05 24.4 0.0 2.4 2 1 0 2 2 2 1 SPRY domain F-box_4 PF15966.5 ELR17188.1 - 0.00091 19.1 1.1 0.0012 18.7 0.3 1.6 1 1 1 2 2 2 1 F-box Coilin_N PF15862.5 ELR17188.1 - 0.01 15.7 4.9 0.36 10.6 6.3 2.1 2 0 0 2 2 2 0 Coilin N-terminus tRNA_lig_CPD PF08302.11 ELR17188.1 - 0.036 13.5 3.1 0.053 13.0 3.1 1.2 1 0 0 1 1 1 0 Fungal tRNA ligase phosphodiesterase domain SR-25 PF10500.9 ELR17188.1 - 0.071 12.7 19.1 0.12 11.9 19.1 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein DUF4604 PF15377.6 ELR17188.1 - 0.072 13.5 12.1 0.12 12.8 12.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4604) Med19 PF10278.9 ELR17188.1 - 0.087 12.8 17.0 0.13 12.2 17.0 1.2 1 0 0 1 1 1 0 Mediator of RNA pol II transcription subunit 19 CMS1 PF14617.6 ELR17188.1 - 0.089 12.1 5.0 0.14 11.5 5.0 1.2 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit OAD_gamma PF04277.13 ELR17188.1 - 0.096 13.3 3.2 0.16 12.6 3.2 1.3 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain Protocadherin PF08374.11 ELR17188.1 - 0.56 10.1 5.9 1 9.3 5.9 1.3 1 0 0 1 1 1 0 Protocadherin Peptidase_S49_N PF08496.10 ELR17188.1 - 0.62 10.1 9.1 0.93 9.5 9.1 1.2 1 0 0 1 1 1 0 Peptidase family S49 N-terminal DUF2829 PF11195.8 ELR17188.1 - 1.5 9.1 4.8 8.6 6.7 0.3 2.5 1 1 0 2 2 2 0 Protein of unknown function (DUF2829) Cnd1_N PF12922.7 ELR17188.1 - 1.5 8.6 7.7 2.1 8.2 6.3 1.7 2 0 0 2 2 2 0 non-SMC mitotic condensation complex subunit 1, N-term AP3D1 PF06375.11 ELR17188.1 - 1.7 8.9 16.9 2.6 8.3 16.9 1.2 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 Peptidase_M19 PF01244.21 ELR17189.1 - 2.1e-72 244.0 0.0 2.6e-72 243.7 0.0 1.1 1 0 0 1 1 1 1 Membrane dipeptidase (Peptidase family M19) TMCO5 PF14992.6 ELR17191.1 - 0.027 14.1 2.0 0.035 13.7 2.0 1.2 1 0 0 1 1 1 0 TMCO5 family HALZ PF02183.18 ELR17191.1 - 0.034 14.4 0.7 0.062 13.5 0.7 1.5 1 0 0 1 1 1 0 Homeobox associated leucine zipper Ax_dynein_light PF10211.9 ELR17191.1 - 0.05 13.5 0.9 0.09 12.7 0.9 1.3 1 0 0 1 1 1 0 Axonemal dynein light chain TPD52 PF04201.15 ELR17191.1 - 0.09 12.4 1.0 0.14 11.8 1.0 1.2 1 0 0 1 1 1 0 Tumour protein D52 family RNA_ligase PF09414.10 ELR17194.1 - 3.9e-10 40.3 0.0 7.2e-10 39.4 0.0 1.4 1 0 0 1 1 1 1 RNA ligase SPRY PF00622.28 ELR17195.1 - 1.9e-09 37.7 0.0 3.6e-09 36.8 0.0 1.4 1 0 0 1 1 1 1 SPRY domain F-box-like PF12937.7 ELR17195.1 - 0.051 13.5 0.4 0.19 11.7 0.4 2.0 1 0 0 1 1 1 0 F-box-like Sporozoite_P67 PF05642.11 ELR17195.1 - 3.7 5.5 5.9 4.9 5.1 5.9 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Pkinase PF00069.25 ELR17196.1 - 5.1e-42 144.1 0.3 3.5e-41 141.3 0.0 2.1 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR17196.1 - 2.9e-12 46.4 0.0 8.7e-12 44.9 0.0 1.7 2 0 0 2 2 2 1 Protein tyrosine kinase U-box PF04564.15 ELR17196.1 - 0.00063 19.9 0.1 0.0057 16.8 0.1 2.5 1 1 0 1 1 1 1 U-box domain Rtf2 PF04641.12 ELR17196.1 - 0.0052 16.2 7.5 0.0052 16.2 7.5 2.9 2 1 1 3 3 3 1 Rtf2 RING-finger LAP1C PF05609.12 ELR17196.1 - 2.2 7.3 16.7 3.2 6.7 16.7 1.2 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) WD40 PF00400.32 ELR17197.1 - 7.3e-48 159.5 23.5 1.1e-07 32.4 1.4 7.6 7 0 0 7 7 7 7 WD domain, G-beta repeat Nup160 PF11715.8 ELR17197.1 - 9.6e-06 24.5 4.6 0.8 8.3 0.1 4.7 4 1 1 5 5 5 3 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ELR17197.1 - 8.2e-05 22.8 1.9 4.7 7.6 0.1 4.7 1 1 3 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain F-box-like PF12937.7 ELR17197.1 - 0.00031 20.6 0.1 0.00068 19.5 0.1 1.6 1 0 0 1 1 1 1 F-box-like WD40_like PF17005.5 ELR17197.1 - 0.0013 18.1 0.0 0.003 17.0 0.0 1.5 1 1 0 1 1 1 1 WD40-like domain PALB2_WD40 PF16756.5 ELR17197.1 - 3.1 6.6 12.0 5.1 5.9 1.2 4.0 1 1 4 5 5 5 0 Partner and localizer of BRCA2 WD40 domain HicB PF05534.12 ELR17198.1 - 0.1 12.4 0.0 20 5.1 0.0 2.5 2 0 0 2 2 2 0 HicB family PP2C PF00481.21 ELR17200.1 - 2.8e-50 171.4 0.3 2.9e-49 168.0 0.0 2.5 2 1 0 2 2 2 1 Protein phosphatase 2C PP2C_2 PF13672.6 ELR17200.1 - 7.7e-06 25.7 0.0 1.8e-05 24.5 0.0 1.5 1 0 0 1 1 1 1 Protein phosphatase 2C LRR_8 PF13855.6 ELR17200.1 - 0.0044 16.7 0.6 0.0069 16.1 0.6 1.3 1 0 0 1 1 1 1 Leucine rich repeat DUF4298 PF14131.6 ELR17200.1 - 0.025 14.5 0.2 0.063 13.2 0.2 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4298) LRR_4 PF12799.7 ELR17200.1 - 0.11 13.0 0.2 0.37 11.3 0.2 1.8 1 1 1 2 2 2 0 Leucine Rich repeats (2 copies) Apt1 PF10351.9 ELR17200.1 - 3.3 6.4 9.9 4.7 6.0 9.9 1.3 1 0 0 1 1 1 0 Golgi-body localisation protein domain LRR_8 PF13855.6 ELR17201.1 - 3.9e-28 97.0 54.3 7.1e-08 32.1 0.4 5.5 2 1 6 8 8 8 8 Leucine rich repeat LRR_4 PF12799.7 ELR17201.1 - 1.2e-21 76.4 25.7 1.1e-05 25.7 0.6 6.4 5 1 1 6 6 6 6 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 ELR17201.1 - 1.8e-09 36.8 13.7 1.4 9.8 0.6 8.4 8 1 1 9 9 9 4 Leucine Rich Repeat LRR_9 PF14580.6 ELR17201.1 - 0.00014 21.4 11.9 0.13 11.7 0.1 3.6 2 1 2 4 4 4 3 Leucine-rich repeat LRR_6 PF13516.6 ELR17201.1 - 0.0044 17.0 18.3 2.4 8.4 0.0 7.3 8 0 0 8 8 8 2 Leucine Rich repeat Pex26 PF07163.12 ELR17201.1 - 0.097 12.0 0.3 0.14 11.4 0.3 1.2 1 0 0 1 1 1 0 Pex26 protein Copine PF07002.16 ELR17203.1 - 1.9e-78 262.8 0.0 2.7e-78 262.4 0.0 1.2 1 0 0 1 1 1 1 Copine C2 PF00168.30 ELR17203.1 - 6.4e-25 87.4 0.1 5.6e-14 52.3 0.0 2.4 2 0 0 2 2 2 2 C2 domain vWA-TerF-like PF10138.9 ELR17203.1 - 1.5e-05 25.2 0.0 4.7e-05 23.6 0.0 1.8 1 1 1 2 2 2 1 vWA found in TerF C terminus Kelch_1 PF01344.25 ELR17203.1 - 0.068 12.8 0.0 0.22 11.1 0.0 1.8 1 0 0 1 1 1 0 Kelch motif Skp1 PF01466.19 ELR17205.1 - 7.9e-30 102.7 1.0 1.4e-29 101.9 1.0 1.4 1 0 0 1 1 1 1 Skp1 family, dimerisation domain Skp1_POZ PF03931.15 ELR17205.1 - 2.7e-27 94.7 0.5 6.4e-27 93.5 0.2 1.8 2 0 0 2 2 2 1 Skp1 family, tetramerisation domain Myb_DNA-binding PF00249.31 ELR17205.1 - 0.15 12.3 0.5 18 5.6 0.3 2.4 2 0 0 2 2 2 0 Myb-like DNA-binding domain DUF3659 PF12396.8 ELR17206.1 - 0.027 14.4 0.9 2.5 8.1 0.0 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF3659) Rab_eff_C PF04698.12 ELR17206.1 - 0.28 9.4 0.0 0.35 9.1 0.0 1.0 1 0 0 1 1 1 0 Rab effector MyRIP/melanophilin C-terminus SNAP PF14938.6 ELR17207.1 - 4.6e-82 275.6 4.5 1.1e-81 274.4 4.5 1.5 1 1 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_12 PF13424.6 ELR17207.1 - 7.9e-09 35.7 11.8 0.013 15.8 0.7 3.7 3 1 0 3 3 3 3 Tetratricopeptide repeat DHR-2 PF06920.13 ELR17207.1 - 4.2e-05 22.4 0.0 0.00011 21.0 0.0 1.6 2 0 0 2 2 2 1 Dock homology region 2 TPR_7 PF13176.6 ELR17207.1 - 0.0022 17.9 6.4 0.75 10.0 0.4 5.1 4 2 2 6 6 5 1 Tetratricopeptide repeat BTAD PF03704.17 ELR17207.1 - 0.0039 17.6 0.9 0.24 11.8 0.0 2.7 1 1 1 2 2 2 1 Bacterial transcriptional activator domain TPR_2 PF07719.17 ELR17207.1 - 0.007 16.4 19.8 0.17 12.1 1.6 5.9 5 1 1 6 6 6 2 Tetratricopeptide repeat TPR_6 PF13174.6 ELR17207.1 - 0.015 15.9 7.2 17 6.3 0.1 5.3 4 1 2 6 6 6 0 Tetratricopeptide repeat TPR_16 PF13432.6 ELR17207.1 - 0.02 15.6 7.9 0.71 10.6 0.2 3.9 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_1 PF00515.28 ELR17207.1 - 0.036 13.9 12.4 2.5 8.1 0.2 4.9 4 1 1 5 5 5 0 Tetratricopeptide repeat TPR_8 PF13181.6 ELR17207.1 - 0.057 13.7 9.3 30 5.2 0.3 5.3 5 2 1 6 6 5 0 Tetratricopeptide repeat NSF PF02071.20 ELR17207.1 - 0.058 14.1 22.7 0.88 10.6 1.9 6.5 7 1 1 8 8 5 0 Aromatic-di-Alanine (AdAR) repeat DUF410 PF04190.13 ELR17207.1 - 0.11 12.3 0.3 3.8 7.2 0.0 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF410) HHH_8 PF14716.6 ELR17207.1 - 0.12 12.8 1.3 3 8.3 0.1 2.6 2 0 0 2 2 2 0 Helix-hairpin-helix domain Clathrin PF00637.20 ELR17207.1 - 1 9.3 3.4 1.3 8.9 0.2 2.7 3 1 0 3 3 3 0 Region in Clathrin and VPS HemY_N PF07219.13 ELR17207.1 - 8.8 6.6 6.9 1.3 9.2 0.1 2.7 3 0 0 3 3 3 0 HemY protein N-terminus Citrate_bind PF16114.5 ELR17208.1 - 2.7e-82 274.6 0.0 4.7e-82 273.8 0.0 1.4 1 0 0 1 1 1 1 ATP citrate lyase citrate-binding Citrate_synt PF00285.21 ELR17208.1 - 6.2e-19 68.3 0.0 8.2e-16 58.0 0.0 2.5 1 1 1 2 2 2 2 Citrate synthase, C-terminal domain Ligase_CoA PF00549.19 ELR17208.1 - 5.2e-16 58.8 0.0 1e-15 57.9 0.0 1.5 1 0 0 1 1 1 1 CoA-ligase ATP-grasp_2 PF08442.10 ELR17208.1 - 9.2e-10 38.4 0.0 1.8e-09 37.5 0.0 1.5 1 0 0 1 1 1 1 ATP-grasp domain CoA_binding PF02629.19 ELR17208.1 - 6.8e-07 29.9 0.0 2.2e-06 28.3 0.0 1.9 2 0 0 2 2 2 1 CoA binding domain Succ_CoA_lig PF13607.6 ELR17208.1 - 0.00053 19.8 0.0 0.0018 18.0 0.0 1.9 2 0 0 2 2 2 1 Succinyl-CoA ligase like flavodoxin domain DEAD_2 PF06733.15 ELR17209.1 - 2.8e-49 167.1 0.0 4.3e-49 166.5 0.0 1.3 1 0 0 1 1 1 1 DEAD_2 HBB PF06777.11 ELR17209.1 - 7.4e-33 113.8 0.1 1.8e-27 96.3 0.0 2.5 2 0 0 2 2 2 2 Helical and beta-bridge domain Helicase_C_2 PF13307.6 ELR17209.1 - 2.2e-20 73.5 0.2 5.1e-20 72.3 0.2 1.6 1 0 0 1 1 1 1 Helicase C-terminal domain ResIII PF04851.15 ELR17209.1 - 0.011 15.8 0.0 4.3 7.3 0.0 2.4 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit SNF2_N PF00176.23 ELR17209.1 - 0.046 12.4 0.0 0.25 10.0 0.0 2.0 1 1 0 1 1 1 0 SNF2 family N-terminal domain DUF2075 PF09848.9 ELR17209.1 - 0.16 11.1 0.0 11 5.1 0.0 2.2 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) Coprogen_oxidas PF01218.18 ELR17210.1 - 1.6e-105 352.1 0.0 1.9e-105 351.9 0.0 1.0 1 0 0 1 1 1 1 Coproporphyrinogen III oxidase Ribosomal_L15e PF00827.17 ELR17211.1 - 6.8e-82 273.8 10.1 1.3e-81 272.9 10.1 1.4 1 1 0 1 1 1 1 Ribosomal L15 ABA_GPCR PF12430.8 ELR17212.1 - 1.7e-39 135.4 10.2 1.7e-39 135.4 10.2 1.8 2 0 0 2 2 2 1 Abscisic acid G-protein coupled receptor GPHR_N PF12537.8 ELR17212.1 - 1.3e-16 60.4 0.1 4.3e-16 58.8 0.1 1.9 1 1 0 1 1 1 1 The Golgi pH Regulator (GPHR) Family N-terminal GDI PF00996.18 ELR17213.1 - 6.7e-205 680.6 2.6 1.4e-105 353.3 0.1 2.0 1 1 1 2 2 2 2 GDP dissociation inhibitor Amino_oxidase PF01593.24 ELR17213.1 - 3.6e-05 23.3 0.0 5e-05 22.8 0.0 1.2 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase Mito_carr PF00153.27 ELR17214.1 - 6.7e-70 231.1 2.7 8.1e-25 86.6 0.1 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 ELR17214.1 - 0.0037 16.5 1.5 0.75 8.9 0.1 3.6 3 2 1 5 5 5 2 Gammaproteobacterial serine protease NAD_binding_5 PF07994.12 ELR17215.1 - 2.6e-145 483.8 0.1 3.1e-145 483.6 0.1 1.0 1 0 0 1 1 1 1 Myo-inositol-1-phosphate synthase Inos-1-P_synth PF01658.17 ELR17215.1 - 5.9e-47 158.4 0.2 2.2e-46 156.6 0.2 1.9 2 0 0 2 2 2 1 Myo-inositol-1-phosphate synthase TQ PF18202.1 ELR17215.1 - 0.22 12.1 1.8 3.1 8.3 0.9 2.3 2 0 0 2 2 2 0 T-Q ester bond containing domain Cyt-b5 PF00173.28 ELR17216.1 - 3.2e-20 72.1 0.0 4.5e-20 71.6 0.0 1.2 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Jiv90 PF14901.6 ELR17216.1 - 0.37 11.0 1.6 1.3 9.2 0.7 2.3 1 1 1 2 2 2 0 Cleavage inducing molecular chaperone PPP4R2 PF09184.11 ELR17217.1 - 1.5e-11 44.4 0.0 3.2e-07 30.2 0.0 2.1 2 0 0 2 2 2 2 PPP4R2 DUF1631 PF07793.11 ELR17217.1 - 0.075 11.4 0.1 0.12 10.8 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1631) HSP90 PF00183.18 ELR17218.1 - 6.4e-184 612.7 5.0 9e-184 612.2 5.0 1.2 1 0 0 1 1 1 1 Hsp90 protein HATPase_c PF02518.26 ELR17218.1 - 1.9e-12 47.7 0.1 3.3e-12 46.9 0.1 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 ELR17218.1 - 4.5e-11 42.7 0.3 1e-10 41.6 0.3 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HSP70 PF00012.20 ELR17219.1 - 1.4e-266 885.5 8.7 1.6e-266 885.3 8.7 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 ELR17219.1 - 2.7e-14 52.7 0.9 1.2e-11 44.0 0.2 2.6 2 1 0 2 2 2 2 MreB/Mbl protein FtsA PF14450.6 ELR17219.1 - 3.9e-05 24.0 0.1 0.087 13.3 0.0 3.2 3 1 0 3 3 3 2 Cell division protein FtsA FGGY_C PF02782.16 ELR17219.1 - 0.0024 17.6 0.0 0.0079 15.9 0.0 1.9 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain Ribosomal_L27A PF00828.19 ELR17220.1 - 3.1e-34 118.4 2.6 4.9e-34 117.8 2.6 1.3 1 0 0 1 1 1 1 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A Arm PF00514.23 ELR17221.1 - 9e-07 28.7 0.5 0.053 13.6 0.0 2.4 2 0 0 2 2 2 2 Armadillo/beta-catenin-like repeat NOA36 PF06524.12 ELR17221.1 - 0.15 11.4 7.6 0.22 10.8 7.6 1.3 1 0 0 1 1 1 0 NOA36 protein Cwf_Cwc_15 PF04889.12 ELR17221.1 - 0.24 11.1 8.3 0.28 10.9 8.3 1.1 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein EF-hand_12 PF17901.1 ELR17222.1 - 1.6e-41 140.7 1.5 4.7e-41 139.2 1.5 1.9 1 0 0 1 1 1 1 EF-hand fold domain STATa_Ig PF18214.1 ELR17222.1 - 8.2e-30 103.3 0.9 2.5e-29 101.8 0.9 1.8 1 0 0 1 1 1 1 STATa Immunoglobulin-like domain Dict-STAT-coil PF09267.10 ELR17222.1 - 7.1e-11 42.5 21.8 7.1e-11 42.5 21.8 2.1 2 0 0 2 2 2 1 Dictyostelium STAT, coiled coil SH2 PF00017.24 ELR17222.1 - 2.6e-09 37.1 0.0 1e-08 35.2 0.0 2.1 2 0 0 2 2 2 1 SH2 domain Cbl_N3 PF02762.14 ELR17222.1 - 0.085 12.7 0.0 0.24 11.3 0.0 1.7 1 0 0 1 1 1 0 CBL proto-oncogene N-terminus, SH2-like domain TFIIA PF03153.13 ELR17222.1 - 9.9 6.0 17.2 15 5.5 17.2 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit TPR_1 PF00515.28 ELR17223.1 - 3.9e-12 45.4 7.6 0.00059 19.6 0.0 3.8 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.17 ELR17223.1 - 1.6e-11 43.3 12.1 0.00034 20.5 1.2 4.3 4 0 0 4 4 4 3 Tetratricopeptide repeat C1_1 PF00130.22 ELR17223.1 - 1.2e-07 31.5 17.8 0.00021 21.1 1.4 3.6 4 0 0 4 4 4 2 Phorbol esters/diacylglycerol binding domain (C1 domain) TPR_12 PF13424.6 ELR17223.1 - 1.6e-07 31.5 8.2 0.0024 18.1 1.1 3.3 2 1 1 3 3 3 3 Tetratricopeptide repeat F-box-like PF12937.7 ELR17223.1 - 9.9e-07 28.6 0.1 2.1e-06 27.5 0.1 1.5 1 0 0 1 1 1 1 F-box-like TPR_6 PF13174.6 ELR17223.1 - 0.00034 21.0 2.9 0.24 12.1 0.7 3.6 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_8 PF13181.6 ELR17223.1 - 0.00064 19.7 3.4 0.71 10.2 0.1 3.7 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_17 PF13431.6 ELR17223.1 - 0.00066 19.9 4.0 2.1 8.9 0.1 3.9 3 0 0 3 3 3 1 Tetratricopeptide repeat F-box PF00646.33 ELR17223.1 - 0.0013 18.6 0.1 0.0027 17.6 0.1 1.4 1 0 0 1 1 1 1 F-box domain TPR_9 PF13371.6 ELR17223.1 - 0.0047 17.0 7.9 0.21 11.8 0.1 3.4 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_7 PF13176.6 ELR17223.1 - 0.0065 16.4 4.3 0.12 12.5 0.3 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_16 PF13432.6 ELR17223.1 - 0.0071 17.0 2.6 0.0071 17.0 2.6 4.0 4 0 0 4 4 4 1 Tetratricopeptide repeat ANAPC3 PF12895.7 ELR17223.1 - 0.0079 16.4 2.3 1.1 9.5 0.5 2.8 2 1 0 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 3 DUF1772 PF08592.11 ELR17223.1 - 0.053 13.8 0.8 0.19 12.1 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF1772) TPR_14 PF13428.6 ELR17223.1 - 0.1 13.5 13.5 1.1 10.2 2.0 4.4 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_4 PF07721.14 ELR17223.1 - 0.1 13.3 4.2 0.41 11.4 4.2 2.1 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_11 PF13414.6 ELR17223.1 - 0.12 12.1 9.1 4.1 7.2 0.1 4.9 4 2 2 6 6 6 0 TPR repeat TPR_10 PF13374.6 ELR17223.1 - 0.97 9.4 5.5 0.93 9.5 0.5 3.2 3 0 0 3 3 2 0 Tetratricopeptide repeat DUF4611 PF15387.6 ELR17224.1 - 0.15 12.3 4.3 12 6.2 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4611) PBP1_TM PF14812.6 ELR17224.1 - 3 8.3 8.3 4.5 7.7 2.3 2.2 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal RabGAP-TBC PF00566.18 ELR17227.1 - 1.1e-44 152.6 0.4 1.9e-44 151.9 0.0 1.5 2 0 0 2 2 2 1 Rab-GTPase-TBC domain FKBP_N PF01346.18 ELR17227.1 - 0.4 11.7 5.0 0.75 10.8 5.0 1.4 1 0 0 1 1 1 0 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase SPOUT_MTase PF02590.17 ELR17227.1 - 0.45 10.5 2.1 0.74 9.8 2.1 1.2 1 0 0 1 1 1 0 Predicted SPOUT methyltransferase Glyco_transf_25 PF01755.17 ELR17228.1 - 0.0021 18.0 0.0 0.0029 17.5 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase family 25 (LPS biosynthesis protein) CAP_N PF01213.19 ELR17228.1 - 0.06 12.8 2.6 0.11 12.0 2.6 1.4 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal Caskin-Pro-rich PF16907.5 ELR17228.1 - 0.12 12.9 1.4 0.27 11.8 1.4 1.7 1 0 0 1 1 1 0 Proline rich region of Caskin proteins PRIMA1 PF16101.5 ELR17228.1 - 0.13 12.3 0.3 0.32 11.0 0.3 1.7 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 IspD PF01128.19 ELR17229.1 - 0.02 14.6 0.0 0.026 14.2 0.0 1.2 1 0 0 1 1 1 0 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase Ribosomal_L19e PF01280.20 ELR17230.1 - 0.022 14.8 4.7 0.061 13.4 4.7 1.6 1 0 0 1 1 1 0 Ribosomal protein L19e Folliculin PF11704.8 ELR17230.1 - 0.17 11.7 2.4 0.35 10.7 2.4 1.5 1 0 0 1 1 1 0 Vesicle coat protein involved in Golgi to plasma membrane transport TALPID3 PF15324.6 ELR17230.1 - 0.52 7.9 8.6 0.73 7.4 8.6 1.1 1 0 0 1 1 1 0 Hedgehog signalling target DUF1840 PF08895.11 ELR17230.1 - 0.82 10.0 5.1 1.8 9.0 5.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF1840) Glyco_transf_25 PF01755.17 ELR17232.1 - 2.4e-08 34.1 0.0 4.8e-08 33.1 0.0 1.5 1 1 0 1 1 1 1 Glycosyltransferase family 25 (LPS biosynthesis protein) PAN_1 PF00024.26 ELR17232.1 - 0.0012 18.8 0.3 0.0021 18.0 0.3 1.3 1 0 0 1 1 1 1 PAN domain Gly_transf_sug PF04488.15 ELR17232.1 - 0.0039 17.8 0.0 0.0086 16.7 0.0 1.5 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif CAP_N PF01213.19 ELR17232.1 - 0.17 11.4 2.5 0.29 10.6 2.5 1.3 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal Glyco_transf_25 PF01755.17 ELR17234.1 - 4.7e-07 29.9 0.0 9e-07 29.0 0.0 1.5 1 0 0 1 1 1 1 Glycosyltransferase family 25 (LPS biosynthesis protein) PAN_4 PF14295.6 ELR17234.1 - 0.0016 18.3 3.7 0.0037 17.1 3.7 1.6 1 0 0 1 1 1 1 PAN domain Gly_transf_sug PF04488.15 ELR17234.1 - 0.0034 18.0 0.0 0.0069 17.0 0.0 1.5 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif PAN_1 PF00024.26 ELR17234.1 - 0.0043 17.0 0.4 0.0083 16.1 0.4 1.3 1 0 0 1 1 1 1 PAN domain Glyco_transf_25 PF01755.17 ELR17235.1 - 6e-08 32.8 0.0 9.9e-08 32.1 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 25 (LPS biosynthesis protein) PAN_1 PF00024.26 ELR17235.1 - 0.0016 18.4 0.3 0.0031 17.4 0.3 1.4 1 0 0 1 1 1 1 PAN domain Gly_transf_sug PF04488.15 ELR17235.1 - 0.0061 17.2 0.0 0.012 16.2 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif PAN_4 PF14295.6 ELR17235.1 - 0.19 11.7 6.0 0.46 10.4 6.0 1.6 1 0 0 1 1 1 0 PAN domain Sel1 PF08238.12 ELR17236.1 - 3.2e-56 186.5 43.8 7.1e-09 36.1 2.2 7.4 7 0 0 7 7 7 7 Sel1 repeat TPR_16 PF13432.6 ELR17236.1 - 0.0002 21.9 46.3 0.19 12.4 11.5 5.4 2 1 3 6 6 6 3 Tetratricopeptide repeat DUF2225 PF09986.9 ELR17236.1 - 0.18 11.5 0.4 41 3.8 0.0 3.2 2 1 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2225) TPR_11 PF13414.6 ELR17236.1 - 1.6 8.5 26.7 7.7 6.3 0.0 7.5 7 3 0 7 7 7 0 TPR repeat CLTH PF10607.9 ELR17237.1 - 3.1e-29 101.8 0.0 4.6e-29 101.2 0.0 1.3 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain PTN13_u3 PF16599.5 ELR17237.1 - 0.055 13.5 0.3 0.086 12.9 0.3 1.2 1 0 0 1 1 1 0 Unstructured linker region on PTN13 protein between PDZ Phage_GPO PF05929.11 ELR17237.1 - 0.14 11.8 2.2 0.36 10.4 1.8 1.8 2 0 0 2 2 2 0 Phage capsid scaffolding protein (GPO) serine peptidase DHHC PF01529.20 ELR17238.1 - 6.2e-18 65.2 1.9 6.2e-18 65.2 1.9 2.3 2 0 0 2 2 2 1 DHHC palmitoyltransferase FtsX PF02687.21 ELR17238.1 - 0.3 11.6 0.0 0.3 11.6 0.0 3.0 3 0 0 3 3 3 0 FtsX-like permease family Ribosomal_L13e PF01294.18 ELR17239.1 - 3.8e-70 235.4 4.9 5.4e-70 234.9 4.9 1.2 1 0 0 1 1 1 1 Ribosomal protein L13e DUF4187 PF13821.6 ELR17240.1 - 1.5e-19 69.5 1.1 4.1e-19 68.1 1.1 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF4187) G-patch PF01585.23 ELR17240.1 - 1.3e-11 44.1 0.6 2.4e-11 43.3 0.6 1.4 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.7 ELR17240.1 - 0.00026 21.0 0.4 0.00026 21.0 0.4 2.0 2 0 0 2 2 2 1 G-patch domain DUF3240 PF11582.8 ELR17240.1 - 0.13 12.4 0.0 0.42 10.8 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3240) Med30 PF11315.8 ELR17240.1 - 2.1 8.5 5.7 0.58 10.3 2.6 1.6 2 0 0 2 2 2 0 Mediator complex subunit 30 SapB_2 PF03489.17 ELR17242.1 - 6.3e-24 83.8 16.1 2.5e-12 46.7 3.4 3.5 3 0 0 3 3 3 2 Saposin-like type B, region 2 SapB_1 PF05184.15 ELR17242.1 - 2.8e-22 78.3 2.7 5.3e-10 39.1 0.3 3.2 2 0 0 2 2 2 2 Saposin-like type B, region 1 YyzF PF14116.6 ELR17242.1 - 0.092 12.8 6.1 0.26 11.3 0.7 3.3 3 0 0 3 3 3 0 YyzF-like protein Glyco_transf_25 PF01755.17 ELR17243.1 - 1.3e-05 25.2 0.0 2.5e-05 24.2 0.0 1.4 1 1 0 1 1 1 1 Glycosyltransferase family 25 (LPS biosynthesis protein) Gly_transf_sug PF04488.15 ELR17243.1 - 0.00011 22.8 0.0 0.0003 21.4 0.0 1.7 2 0 0 2 2 2 1 Glycosyltransferase sugar-binding region containing DXD motif PAN_4 PF14295.6 ELR17243.1 - 0.0044 16.9 5.1 0.011 15.6 5.1 1.6 1 0 0 1 1 1 1 PAN domain EF-hand_7 PF13499.6 ELR17244.1 - 2.2e-13 50.4 0.0 1.8e-09 37.9 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 ELR17244.1 - 2.2e-12 45.8 0.2 3.1e-05 23.6 0.0 4.4 4 0 0 4 4 4 2 EF-hand domain EF-hand_1 PF00036.32 ELR17244.1 - 1.2e-11 43.2 0.0 0.0016 17.8 0.0 4.6 5 0 0 5 5 5 2 EF hand EF-hand_5 PF13202.6 ELR17244.1 - 4.2e-10 38.7 0.0 3.8e-05 23.0 0.0 4.0 4 0 0 4 4 4 2 EF hand EF-hand_8 PF13833.6 ELR17244.1 - 9.6e-10 38.2 0.0 0.0061 16.4 0.0 3.7 3 1 1 4 4 4 3 EF-hand domain pair Phage_min_tail PF05939.13 ELR17244.1 - 0.054 13.9 0.0 0.1 13.0 0.0 1.4 1 0 0 1 1 1 0 Phage minor tail protein Amidohydro_1 PF01979.20 ELR17245.1 - 1.7e-27 96.7 0.1 2.7e-27 96.0 0.1 1.3 1 1 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 ELR17245.1 - 4.6e-13 49.5 7.9 1.7e-07 31.1 0.1 3.2 2 1 1 3 3 3 3 Amidohydrolase family Amidohydro_2 PF04909.14 ELR17245.1 - 0.00072 19.4 0.6 0.0014 18.5 0.6 1.5 1 0 0 1 1 1 1 Amidohydrolase CRAM_rpt PF07016.11 ELR17246.1 - 0.093 12.5 1.8 0.19 11.6 1.8 1.5 1 0 0 1 1 1 0 Cysteine-rich acidic integral membrane protein precursor zf-MYND PF01753.18 ELR17246.1 - 0.91 9.7 6.3 0.22 11.6 2.7 2.0 2 1 0 2 2 2 0 MYND finger Peptidase_M24 PF00557.24 ELR17247.1 - 5.3e-56 189.6 0.4 2.2e-55 187.6 0.4 1.8 2 0 0 2 2 2 1 Metallopeptidase family M24 AMP_N PF05195.16 ELR17247.1 - 7.9e-29 99.9 0.0 1.6e-28 98.9 0.0 1.5 1 0 0 1 1 1 1 Aminopeptidase P, N-terminal domain NUDIX PF00293.28 ELR17248.1 - 4.4e-16 59.1 1.0 5.9e-16 58.7 1.0 1.2 1 0 0 1 1 1 1 NUDIX domain Amnionless PF14828.6 ELR17249.1 - 0.026 13.4 0.0 0.032 13.1 0.0 1.1 1 0 0 1 1 1 0 Amnionless DAP10 PF07213.11 ELR17249.1 - 0.027 14.4 1.7 0.045 13.7 1.7 1.3 1 0 0 1 1 1 0 DAP10 membrane protein TMEM51 PF15345.6 ELR17249.1 - 0.063 13.1 0.8 0.071 12.9 0.0 1.6 2 0 0 2 2 2 0 Transmembrane protein 51 EphA2_TM PF14575.6 ELR17249.1 - 0.078 13.9 0.0 0.12 13.2 0.0 1.4 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Gal_Lectin PF02140.18 ELR17250.1 - 1.2e-05 25.6 0.1 4e-05 24.0 0.1 1.9 1 0 0 1 1 1 1 Galactose binding lectin domain FG-GAP PF01839.23 ELR17250.1 - 0.00036 20.6 0.6 0.00036 20.6 0.6 3.8 4 0 0 4 4 4 1 FG-GAP repeat VCBS PF13517.6 ELR17250.1 - 0.00052 20.6 14.0 0.0058 17.2 1.6 4.1 4 1 1 5 5 5 2 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella DUF5059 PF16502.5 ELR17250.1 - 0.0084 14.9 0.0 0.013 14.2 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF5059) EGF_2 PF07974.13 ELR17250.1 - 0.65 10.4 7.7 2.1 8.8 7.7 1.9 1 0 0 1 1 1 0 EGF-like domain VCBS PF13517.6 ELR17252.1 - 1.2e-05 25.7 5.6 0.0045 17.5 0.3 3.4 2 0 0 2 2 2 2 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.23 ELR17252.1 - 0.0048 17.0 0.0 0.0048 17.0 0.0 3.5 3 0 0 3 3 3 1 FG-GAP repeat CARDB PF07705.11 ELR17252.1 - 0.24 11.7 2.1 1.6 9.0 0.0 2.9 2 1 0 2 2 2 0 CARDB Remorin_N PF03766.13 ELR17252.1 - 0.59 10.2 6.2 0.32 11.1 1.0 2.6 2 0 0 2 2 2 0 Remorin, N-terminal region Ribosomal_60s PF00428.19 ELR17254.1 - 9.3 6.9 11.4 3.7 8.2 3.9 3.0 2 0 0 2 2 2 0 60s Acidic ribosomal protein DUF4984 PF16372.5 ELR17256.1 - 0.04 13.8 0.0 0.04 13.8 0.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4984) Cpn60_TCP1 PF00118.24 ELR17257.1 - 1.6e-156 521.8 2.0 1.9e-156 521.6 2.0 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Pkinase PF00069.25 ELR17258.1 - 5.7e-54 183.2 0.0 1.1e-53 182.3 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR17258.1 - 1.9e-24 86.4 0.0 3.2e-24 85.6 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase NAF PF03822.14 ELR17258.1 - 1.8e-08 34.4 0.0 4.3e-08 33.2 0.0 1.6 1 0 0 1 1 1 1 NAF domain Kinase-like PF14531.6 ELR17258.1 - 0.00022 20.7 0.0 0.00043 19.7 0.0 1.5 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.14 ELR17258.1 - 0.0028 17.0 0.0 0.006 16.0 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 ELR17258.1 - 0.0036 17.2 0.1 0.011 15.7 0.0 2.0 2 0 0 2 2 2 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 ELR17258.1 - 0.023 14.3 0.0 0.041 13.5 0.0 1.3 1 0 0 1 1 1 0 Choline/ethanolamine kinase KA1 PF02149.19 ELR17258.1 - 0.029 14.2 0.0 0.056 13.2 0.0 1.5 1 0 0 1 1 1 0 Kinase associated domain 1 RIO1 PF01163.22 ELR17258.1 - 0.2 11.2 0.0 0.33 10.5 0.0 1.3 1 0 0 1 1 1 0 RIO1 family DnaJ_C PF01556.18 ELR17259.1 - 4.3e-31 108.0 0.0 6.3e-31 107.5 0.0 1.3 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 ELR17259.1 - 1.6e-24 85.8 1.5 2.5e-24 85.2 1.5 1.3 1 0 0 1 1 1 1 DnaJ domain SET PF00856.28 ELR17260.1 - 1.8e-11 44.7 3.6 5.2e-09 36.7 0.0 3.3 3 0 0 3 3 3 1 SET domain CDC45 PF02724.14 ELR17260.1 - 0.00022 19.7 10.4 0.0003 19.2 10.4 1.1 1 0 0 1 1 1 1 CDC45-like protein Tim54 PF11711.8 ELR17260.1 - 0.059 12.2 11.7 0.1 11.4 11.7 1.3 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 DDHD PF02862.17 ELR17260.1 - 0.068 13.3 0.4 0.12 12.5 0.4 1.4 1 0 0 1 1 1 0 DDHD domain Nop14 PF04147.12 ELR17260.1 - 0.13 10.5 27.1 0.2 9.9 27.1 1.2 1 0 0 1 1 1 0 Nop14-like family Borealin PF10512.9 ELR17260.1 - 0.19 11.7 0.0 0.64 10.0 0.0 1.8 2 0 0 2 2 2 0 Cell division cycle-associated protein 8 SAPS PF04499.15 ELR17260.1 - 0.45 9.2 7.6 0.59 8.9 7.6 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein BUD22 PF09073.10 ELR17260.1 - 0.51 9.6 26.2 0.034 13.5 20.5 1.7 2 0 0 2 2 2 0 BUD22 AAA_11 PF13086.6 ELR17260.1 - 0.71 9.6 5.1 1.2 8.8 5.1 1.3 1 0 0 1 1 1 0 AAA domain Mpp10 PF04006.12 ELR17260.1 - 0.94 7.8 29.3 1.5 7.2 29.3 1.2 1 0 0 1 1 1 0 Mpp10 protein Paramyxo_ncap PF00973.19 ELR17260.1 - 2.5 6.9 4.3 3.5 6.5 4.3 1.1 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein PPL5 PF18168.1 ELR17260.1 - 3.1 7.0 11.4 4.9 6.4 11.4 1.3 1 0 0 1 1 1 0 Prim-pol family 5 Sec62 PF03839.16 ELR17260.1 - 4.1 6.8 11.4 9.2 5.7 11.4 1.6 1 1 0 1 1 1 0 Translocation protein Sec62 Zip PF02535.22 ELR17260.1 - 6.3 5.9 11.3 9.6 5.3 11.3 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter SLC12 PF03522.15 ELR17260.1 - 9.3 5.2 8.0 14 4.6 8.0 1.2 1 0 0 1 1 1 0 Solute carrier family 12 Ank_4 PF13637.6 ELR17261.1 - 0.00038 21.0 0.0 0.00078 20.0 0.0 1.6 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank PF00023.30 ELR17261.1 - 0.011 16.2 0.1 0.65 10.5 0.0 2.6 2 0 0 2 2 2 0 Ankyrin repeat Ank_5 PF13857.6 ELR17261.1 - 0.02 15.2 0.0 0.047 14.0 0.0 1.6 1 0 0 1 1 1 0 Ankyrin repeats (many copies) ZZ PF00569.17 ELR17263.1 - 0.0001 22.0 0.3 0.00017 21.3 0.3 1.3 1 0 0 1 1 1 1 Zinc finger, ZZ type F-box-like PF12937.7 ELR17263.1 - 0.00076 19.3 0.2 0.0016 18.3 0.2 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ELR17263.1 - 0.094 12.6 0.1 0.22 11.5 0.1 1.5 1 0 0 1 1 1 0 F-box domain Laminin_G_3 PF13385.6 ELR17263.1 - 0.12 12.5 0.8 12 6.1 0.0 2.7 2 1 0 2 2 2 0 Concanavalin A-like lectin/glucanases superfamily RCC1_2 PF13540.6 ELR17264.1 - 3.9e-19 67.9 43.0 1.4e-08 34.3 2.3 6.9 7 0 0 7 7 7 5 Regulator of chromosome condensation (RCC1) repeat SKG6 PF08693.10 ELR17264.1 - 0.011 15.1 7.7 0.04 13.3 7.7 2.0 1 0 0 1 1 1 0 Transmembrane alpha-helix domain LapA_dom PF06305.11 ELR17264.1 - 0.42 10.5 3.1 0.42 10.5 0.1 2.5 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain SPX PF03105.19 ELR17264.1 - 9.6 6.0 14.5 14 5.5 14.5 1.1 1 0 0 1 1 1 0 SPX domain NatB_MDM20 PF09797.9 ELR17265.1 - 2.2e-55 188.1 9.1 4.6e-54 183.8 0.9 3.4 3 1 0 3 3 3 1 N-acetyltransferase B complex (NatB) non catalytic subunit TPR_15 PF13429.6 ELR17265.1 - 0.0053 16.0 9.8 0.1 11.8 5.6 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_14 PF13428.6 ELR17265.1 - 0.011 16.5 20.1 5.9 8.0 0.1 8.1 6 1 2 8 8 8 0 Tetratricopeptide repeat TPR_16 PF13432.6 ELR17265.1 - 0.02 15.6 0.0 0.02 15.6 0.0 6.2 7 0 0 7 7 7 0 Tetratricopeptide repeat TPR_19 PF14559.6 ELR17265.1 - 0.03 14.8 20.3 0.071 13.6 0.5 6.5 6 2 1 7 7 7 0 Tetratricopeptide repeat EspB PF05802.11 ELR17265.1 - 0.29 11.1 3.3 1 9.3 3.3 2.0 1 1 0 1 1 1 0 Enterobacterial EspB protein TPR_8 PF13181.6 ELR17265.1 - 7.5 7.0 11.2 14 6.2 0.1 4.5 4 0 0 4 4 4 0 Tetratricopeptide repeat Lipase_3 PF01764.25 ELR17266.1 - 1.5e-27 96.2 0.0 7.1e-15 55.1 0.0 2.5 2 0 0 2 2 2 2 Lipase (class 3) Hydrolase_4 PF12146.8 ELR17266.1 - 2.4e-05 23.8 0.0 6.7e-05 22.3 0.0 1.7 1 0 0 1 1 1 1 Serine aminopeptidase, S33 HECW1_helix PF18436.1 ELR17266.1 - 0.0086 16.2 0.1 0.053 13.6 0.0 2.3 2 1 0 2 2 2 1 Helical box domain of E3 ubiquitin-protein ligase HECW1 PEPcase PF00311.17 ELR17267.1 - 1.4e-271 903.2 0.0 8.2e-270 897.3 0.0 2.0 1 1 0 1 1 1 1 Phosphoenolpyruvate carboxylase PEPcase_2 PF14010.6 ELR17267.1 - 4e-05 22.3 0.0 0.00011 20.9 0.0 1.6 2 0 0 2 2 2 1 Phosphoenolpyruvate carboxylase DUF1635 PF07795.11 ELR17267.1 - 0.13 12.1 0.0 0.33 10.8 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1635) HupE_UreJ PF04955.12 ELR17268.1 - 0.033 13.7 6.1 0.071 12.6 6.1 1.5 1 0 0 1 1 1 0 HupE / UreJ protein Sporozoite_P67 PF05642.11 ELR17268.1 - 0.063 11.4 1.6 0.079 11.0 1.6 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Lin-8 PF03353.15 ELR17268.1 - 0.39 10.2 1.8 0.52 9.8 1.8 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist RRM_1 PF00076.22 ELR17269.1 - 1.4e-46 156.2 0.6 7e-19 67.4 0.1 3.4 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 ELR17269.1 - 4.2e-05 23.1 0.0 0.017 14.7 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 ELR17269.1 - 4.9e-05 23.4 0.0 0.042 14.0 0.0 2.7 2 0 0 2 2 2 2 RNA recognition motif RRM_occluded PF16842.5 ELR17269.1 - 0.001 18.9 0.2 0.066 13.1 0.0 3.0 3 0 0 3 3 3 1 Occluded RNA-recognition motif PHM7_cyt PF14703.6 ELR17269.1 - 1.3 9.2 7.6 12 6.1 0.0 4.0 3 1 0 4 4 4 0 Cytosolic domain of 10TM putative phosphate transporter PNP_UDP_1 PF01048.20 ELR17270.1 - 8.1e-67 224.9 8.1 9.3e-29 100.3 0.1 3.1 3 0 0 3 3 3 3 Phosphorylase superfamily VWA_3 PF13768.6 ELR17271.1 - 6.7e-23 81.3 0.0 1.8e-22 80.0 0.0 1.8 1 0 0 1 1 1 1 von Willebrand factor type A domain VIT PF08487.10 ELR17271.1 - 1e-17 64.3 0.0 2.9e-17 62.9 0.0 1.8 1 0 0 1 1 1 1 Vault protein inter-alpha-trypsin domain Actin PF00022.19 ELR17271.1 - 2.8e-12 46.0 0.0 5e-12 45.1 0.0 1.4 1 0 0 1 1 1 1 Actin VWA PF00092.28 ELR17271.1 - 4.3e-11 43.4 0.0 8.4e-11 42.4 0.0 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.6 ELR17271.1 - 5e-09 36.8 0.0 1.9e-08 34.9 0.0 2.1 1 0 0 1 1 1 1 von Willebrand factor type A domain VIT_2 PF13757.6 ELR17271.1 - 4e-06 26.6 0.0 9e-06 25.5 0.0 1.6 1 0 0 1 1 1 1 Vault protein inter-alpha-trypsin domain Actin PF00022.19 ELR17272.1 - 2.8e-72 243.6 0.0 1.8e-71 240.9 0.0 1.9 1 1 0 1 1 1 1 Actin Macoilin PF09726.9 ELR17273.1 - 8.1e-05 21.4 17.9 0.0001 21.0 17.9 1.1 1 0 0 1 1 1 1 Macoilin family DUF919 PF06034.11 ELR17273.1 - 0.062 13.1 2.7 0.17 11.8 1.7 2.1 2 0 0 2 2 2 0 Nucleopolyhedrovirus protein of unknown function (DUF919) GvpL_GvpF PF06386.11 ELR17273.1 - 0.62 10.0 7.6 1.4 8.8 7.6 1.6 1 0 0 1 1 1 0 Gas vesicle synthesis protein GvpL/GvpF DUF724 PF05266.14 ELR17273.1 - 2.2 8.1 12.3 1 9.1 9.7 1.7 1 1 0 2 2 2 0 Protein of unknown function (DUF724) RuvX PF03652.15 ELR17273.1 - 2.5 8.5 7.5 5.7 7.3 6.0 2.3 1 1 0 2 2 2 0 Holliday junction resolvase FUSC PF04632.12 ELR17273.1 - 6.6 5.1 7.4 10 4.5 7.4 1.2 1 0 0 1 1 1 0 Fusaric acid resistance protein family MIR PF02815.19 ELR17274.1 - 8.4e-18 64.9 4.4 2.8e-15 56.7 1.0 3.0 1 1 1 2 2 2 2 MIR domain Ins145_P3_rec PF08709.11 ELR17274.1 - 0.0038 16.4 0.5 0.011 14.9 0.5 1.7 2 1 0 2 2 2 1 Inositol 1,4,5-trisphosphate/ryanodine receptor WD40 PF00400.32 ELR17275.1 - 3.4e-48 160.6 17.3 2.6e-11 43.9 0.1 7.1 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ELR17275.1 - 1.3e-11 44.6 0.1 0.019 15.2 0.0 5.2 1 1 4 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain BBS2_Mid PF14783.6 ELR17275.1 - 0.00053 20.0 0.0 2.8 8.0 0.0 3.6 3 0 0 3 3 3 1 Ciliary BBSome complex subunit 2, middle region Nup160 PF11715.8 ELR17275.1 - 0.0022 16.7 2.3 0.14 10.8 0.2 3.2 2 1 1 4 4 4 2 Nucleoporin Nup120/160 Frtz PF11768.8 ELR17275.1 - 0.0088 14.4 0.6 4.9 5.4 0.0 2.8 2 1 1 3 3 3 2 WD repeat-containing and planar cell polarity effector protein Fritz Kelch_6 PF13964.6 ELR17275.1 - 0.018 15.3 0.3 14 6.2 0.0 3.3 3 0 0 3 3 3 0 Kelch motif PQQ PF01011.21 ELR17275.1 - 0.083 12.9 0.0 0.84 9.7 0.0 2.7 3 0 0 3 3 3 0 PQQ enzyme repeat Ge1_WD40 PF16529.5 ELR17275.1 - 0.17 10.8 0.9 25 3.7 0.0 3.6 1 1 2 4 4 4 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Thioredoxin PF00085.20 ELR17276.1 - 7e-13 48.5 0.0 1.2e-12 47.7 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.6 ELR17276.1 - 0.023 15.1 0.0 0.053 14.0 0.0 1.6 1 0 0 1 1 1 0 Thioredoxin-like domain OST3_OST6 PF04756.13 ELR17276.1 - 0.083 12.2 0.0 0.15 11.4 0.0 1.5 1 1 0 1 1 1 0 OST3 / OST6 family, transporter family Peptidase_C1 PF00112.23 ELR17277.1 - 1e-42 146.7 9.1 1e-42 146.7 9.1 2.1 2 0 0 2 2 2 1 Papain family cysteine protease fn3 PF00041.21 ELR17277.1 - 2.3e-11 43.9 1.1 5.8e-11 42.6 1.1 1.7 1 0 0 1 1 1 1 Fibronectin type III domain Cystatin PF00031.21 ELR17277.1 - 0.049 13.9 1.3 0.54 10.6 0.3 2.9 3 0 0 3 3 3 0 Cystatin domain PT PF04886.12 ELR17277.1 - 0.12 11.9 18.4 0.19 11.3 16.7 2.2 1 1 1 2 2 2 0 PT repeat DUF4690 PF15756.5 ELR17277.1 - 0.38 11.4 4.8 1.4 9.5 4.8 2.1 1 0 0 1 1 1 0 Small Novel Rich in Cartilage RVT_1 PF00078.27 ELR17279.1 - 2.7e-12 46.7 0.4 4.1e-12 46.1 0.4 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) AmiS_UreI PF02293.15 ELR17279.1 - 0.0058 16.6 2.4 0.0095 15.9 2.4 1.3 1 0 0 1 1 1 1 AmiS/UreI family transporter SspB PF04386.13 ELR17279.1 - 0.044 13.7 0.2 0.068 13.1 0.2 1.2 1 0 0 1 1 1 0 Stringent starvation protein B Retrotrans_gag PF03732.17 ELR17281.1 - 0.004 17.4 0.2 0.0066 16.7 0.2 1.4 1 0 0 1 1 1 1 Retrotransposon gag protein DHHC PF01529.20 ELR17282.1 - 4.2e-29 101.3 0.3 4.2e-29 101.3 0.3 1.7 2 0 0 2 2 2 1 DHHC palmitoyltransferase DUF2530 PF10745.9 ELR17282.1 - 5.2 7.4 10.2 22 5.4 0.3 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2530) DENN PF02141.21 ELR17283.1 - 1e-47 162.5 2.4 1.9e-47 161.6 2.4 1.5 1 0 0 1 1 1 1 DENN (AEX-3) domain PH PF00169.29 ELR17283.1 - 3.4e-13 50.0 0.0 6.5e-13 49.1 0.0 1.5 1 0 0 1 1 1 1 PH domain uDENN PF03456.18 ELR17283.1 - 1.5e-12 48.0 0.2 5.4e-12 46.3 0.2 2.1 1 0 0 1 1 1 1 uDENN domain dDENN PF03455.19 ELR17283.1 - 1.7e-11 43.9 1.9 1.7e-11 43.9 1.9 2.2 3 0 0 3 3 3 1 dDENN domain Cupin_8 PF13621.6 ELR17284.1 - 6.6e-21 75.2 0.6 1.7e-20 73.9 0.1 1.9 2 1 0 2 2 2 1 Cupin-like domain BACK PF07707.15 ELR17286.1 - 1.5e-19 70.0 0.2 3.5e-19 68.8 0.2 1.7 1 0 0 1 1 1 1 BTB And C-terminal Kelch BTB PF00651.31 ELR17286.1 - 2.3e-13 50.3 0.0 1.4e-06 28.5 0.0 3.5 3 0 0 3 3 3 2 BTB/POZ domain F5_F8_type_C PF00754.25 ELR17286.1 - 1.9e-07 31.2 0.0 5.1e-07 29.9 0.0 1.7 1 0 0 1 1 1 1 F5/8 type C domain Methyltransf_FA PF12248.8 ELR17286.1 - 5.5e-06 26.6 0.0 1.1e-05 25.7 0.0 1.5 1 0 0 1 1 1 1 Farnesoic acid 0-methyl transferase SET PF00856.28 ELR17287.1 - 0.0031 17.9 0.0 0.0046 17.4 0.0 1.7 1 1 0 1 1 1 1 SET domain Lipase_3 PF01764.25 ELR17289.1 - 5.4e-27 94.4 0.0 2.3e-16 59.9 0.0 2.5 2 0 0 2 2 2 2 Lipase (class 3) Hydrolase_4 PF12146.8 ELR17289.1 - 0.0018 17.6 0.0 0.0059 15.9 0.0 1.8 2 0 0 2 2 2 1 Serine aminopeptidase, S33 DUF2974 PF11187.8 ELR17289.1 - 0.0041 16.7 0.0 0.0093 15.5 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF2974) Abhydrolase_6 PF12697.7 ELR17289.1 - 0.025 15.2 0.0 0.064 13.8 0.0 1.7 1 1 0 1 1 1 0 Alpha/beta hydrolase family Thioesterase PF00975.20 ELR17289.1 - 0.46 10.6 0.0 0.46 10.6 0.0 2.3 2 1 0 2 2 2 0 Thioesterase domain CH PF00307.31 ELR17291.1 - 5e-13 49.2 0.1 1.2e-06 28.6 0.1 2.4 2 0 0 2 2 2 2 Calponin homology (CH) domain CAMSAP_CH PF11971.8 ELR17291.1 - 0.011 15.6 0.0 0.043 13.7 0.0 1.9 2 0 0 2 2 2 0 CAMSAP CH domain EMC3_TMCO1 PF01956.16 ELR17292.1 - 1.9e-52 177.4 0.5 2.9e-52 176.8 0.5 1.3 1 0 0 1 1 1 1 Integral membrane protein EMC3/TMCO1-like D123 PF07065.14 ELR17293.1 - 5.2e-22 78.4 1.0 7.2e-21 74.6 0.0 2.3 2 1 0 2 2 2 1 D123 Opi1 PF08618.10 ELR17293.1 - 0.054 12.8 0.0 0.079 12.2 0.0 1.2 1 0 0 1 1 1 0 Transcription factor Opi1 R2K_2 PF18299.1 ELR17293.1 - 0.061 13.2 0.1 0.12 12.2 0.1 1.4 1 0 0 1 1 1 0 ATP-grasp domain, R2K clade family 2 Ank_2 PF12796.7 ELR17294.1 - 4.5e-39 132.9 11.6 8.8e-13 48.7 2.7 3.3 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ELR17294.1 - 2.6e-38 129.9 5.0 1.8e-08 34.7 0.1 5.2 3 1 2 5 5 5 5 Ankyrin repeats (many copies) Ank_5 PF13857.6 ELR17294.1 - 2e-35 120.3 17.1 7.8e-12 45.2 0.1 5.9 2 2 5 7 7 7 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 ELR17294.1 - 9.9e-35 114.6 7.4 0.00018 21.7 0.0 7.3 8 0 0 8 8 8 6 Ankyrin repeat Ank PF00023.30 ELR17294.1 - 4.4e-31 105.9 18.6 3e-05 24.2 0.1 7.3 7 0 0 7 7 7 6 Ankyrin repeat Sec63 PF02889.16 ELR17295.1 - 1.9e-171 568.0 0.0 3.5e-92 308.2 0.0 2.3 2 0 0 2 2 2 2 Sec63 Brl domain DEAD PF00270.29 ELR17295.1 - 5.2e-49 166.4 3.3 1.3e-25 90.2 0.2 3.8 4 0 0 4 4 4 2 DEAD/DEAH box helicase Helicase_PWI PF18149.1 ELR17295.1 - 2.3e-37 127.6 1.7 4e-37 126.8 0.3 2.3 2 0 0 2 2 1 1 N-terminal helicase PWI domain ResIII PF04851.15 ELR17295.1 - 6.7e-26 91.3 0.1 1.9e-13 50.8 0.0 3.3 3 0 0 3 3 3 2 Type III restriction enzyme, res subunit Helicase_C PF00271.31 ELR17295.1 - 9.8e-17 61.3 0.0 7.5e-08 32.7 0.0 4.0 3 1 0 3 3 3 2 Helicase conserved C-terminal domain AAA_22 PF13401.6 ELR17295.1 - 1.3e-06 28.8 0.2 0.02 15.1 0.1 3.7 2 2 0 2 2 2 2 AAA domain T2SSE PF00437.20 ELR17295.1 - 2.1e-05 23.7 0.0 0.075 12.1 0.0 2.4 2 0 0 2 2 2 2 Type II/IV secretion system protein AAA_25 PF13481.6 ELR17295.1 - 0.0021 17.7 0.3 3.4 7.2 0.1 3.0 2 0 0 2 2 2 2 AAA domain AAA_7 PF12775.7 ELR17295.1 - 0.022 14.3 0.0 4.2 6.8 0.0 2.5 2 0 0 2 2 2 0 P-loop containing dynein motor region Drf_DAD PF06345.11 ELR17295.1 - 0.073 13.1 0.2 14 5.9 0.0 2.8 2 0 0 2 2 2 0 DRF Autoregulatory Domain PhoH PF02562.16 ELR17295.1 - 0.12 11.8 0.0 4.7 6.6 0.0 2.6 2 0 0 2 2 2 0 PhoH-like protein AAA_11 PF13086.6 ELR17295.1 - 0.29 10.9 1.2 24 4.6 0.0 3.5 4 1 0 4 4 4 0 AAA domain SUIM_assoc PF16619.5 ELR17296.1 - 7.1e-05 22.8 0.0 0.0012 18.8 0.0 3.1 2 2 0 2 2 2 1 Unstructured region C-term to UIM in Ataxin3 DUF1640 PF07798.11 ELR17296.1 - 0.045 13.8 13.5 0.31 11.1 3.8 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1640) Baculo_PEP_C PF04513.12 ELR17296.1 - 0.14 12.2 1.4 0.26 11.3 0.3 1.9 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus T6PP_N PF18572.1 ELR17296.1 - 1 9.2 8.0 0.36 10.7 1.1 2.7 2 1 0 2 2 2 0 Trehalose-6-phosphate phosphatase N-terminal helical bundle domain Apolipoprotein PF01442.18 ELR17296.1 - 4.6 7.1 16.7 21 4.9 16.8 1.9 1 1 0 1 1 1 0 Apolipoprotein A1/A4/E domain SR-25 PF10500.9 ELR17297.1 - 0.00044 19.9 52.5 0.00044 19.9 52.5 3.3 1 1 2 3 3 3 1 Nuclear RNA-splicing-associated protein DUF755 PF05501.11 ELR17297.1 - 0.0083 16.4 25.3 0.0083 16.4 25.3 4.2 1 1 3 4 4 4 1 Domain of unknown function (DUF755) Carb_anhydrase PF00194.21 ELR17298.1 - 7.5e-21 74.8 0.0 7.3e-14 51.9 0.0 2.1 2 0 0 2 2 2 2 Eukaryotic-type carbonic anhydrase DUF4536 PF15055.6 ELR17298.1 - 0.043 14.1 0.1 0.15 12.3 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4536) RFX_DNA_binding PF02257.15 ELR17299.1 - 1.7e-20 73.4 0.0 3.1e-20 72.6 0.0 1.5 1 0 0 1 1 1 1 RFX DNA-binding domain Pox_D5 PF03288.16 ELR17299.1 - 0.00037 20.9 0.0 0.00083 19.8 0.0 1.5 1 0 0 1 1 1 1 Poxvirus D5 protein-like Y_phosphatase3 PF13350.6 ELR17300.1 - 1.1e-26 94.3 0.0 1.3e-26 94.1 0.0 1.2 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase2 PF03162.13 ELR17300.1 - 7.1e-09 35.4 0.0 1.3e-08 34.6 0.0 1.4 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase PF00102.27 ELR17300.1 - 0.0033 17.0 0.0 0.0046 16.6 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Myotub-related PF06602.14 ELR17300.1 - 0.027 13.4 0.0 0.04 12.8 0.0 1.1 1 0 0 1 1 1 0 Myotubularin-like phosphatase domain Y_phosphatase3 PF13350.6 ELR17301.1 - 1.4e-06 28.5 0.0 2e-06 28.0 0.0 1.1 1 0 0 1 1 1 1 Tyrosine phosphatase family Stn1 PF10451.9 ELR17301.1 - 0.17 10.8 0.8 0.23 10.4 0.8 1.1 1 0 0 1 1 1 0 Telomere regulation protein Stn1 DnaJ_C PF01556.18 ELR17302.1 - 3.7e-26 92.0 0.0 1.6e-23 83.4 0.0 2.3 2 0 0 2 2 2 2 DnaJ C terminal domain DnaJ_CXXCXGXG PF00684.19 ELR17302.1 - 1.2e-06 28.8 6.9 4.2e-06 27.0 6.9 2.0 1 0 0 1 1 1 1 DnaJ central domain Anti-TRAP PF15777.5 ELR17302.1 - 3.6 7.6 10.1 6.6 6.8 3.8 2.8 1 1 1 2 2 2 0 Tryptophan RNA-binding attenuator protein inhibitory protein F-box-like PF12937.7 ELR17303.1 - 1.1e-06 28.4 0.6 2.7e-06 27.2 0.1 1.9 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 ELR17303.1 - 0.00014 21.7 0.0 0.00029 20.6 0.0 1.6 1 0 0 1 1 1 1 F-box domain Arf PF00025.21 ELR17304.1 - 1.5e-05 24.5 0.0 0.032 13.7 0.0 2.2 2 0 0 2 2 2 2 ADP-ribosylation factor family ABC_tran PF00005.27 ELR17305.1 - 1.5e-26 93.5 0.0 5.3e-26 91.8 0.0 1.9 1 1 0 1 1 1 1 ABC transporter ABC_membrane PF00664.23 ELR17305.1 - 2.6e-14 53.5 9.9 2.6e-14 53.5 9.9 1.5 2 0 0 2 2 2 1 ABC transporter transmembrane region SMC_N PF02463.19 ELR17305.1 - 6.5e-13 48.6 0.0 1.1e-08 34.9 0.0 2.3 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 ELR17305.1 - 9.3e-11 42.1 0.1 9.6e-06 25.6 0.0 2.2 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system NACHT PF05729.12 ELR17305.1 - 1e-05 25.5 0.1 0.043 13.7 0.0 2.6 2 0 0 2 2 2 2 NACHT domain AAA_25 PF13481.6 ELR17305.1 - 0.00012 21.7 0.2 0.00079 19.0 0.0 2.3 3 0 0 3 3 3 1 AAA domain AAA_23 PF13476.6 ELR17305.1 - 0.0025 18.4 0.1 0.0046 17.5 0.1 1.3 1 0 0 1 1 1 1 AAA domain AAA_29 PF13555.6 ELR17305.1 - 0.0044 16.7 0.0 0.0093 15.7 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_15 PF13175.6 ELR17305.1 - 0.0075 16.0 0.0 0.012 15.3 0.0 1.2 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 ELR17305.1 - 0.019 15.2 0.2 3 8.1 0.0 2.8 3 0 0 3 3 3 0 AAA domain DEAD PF00270.29 ELR17305.1 - 0.033 13.9 0.1 0.41 10.4 0.0 2.1 2 0 0 2 2 2 0 DEAD/DEAH box helicase AAA_16 PF13191.6 ELR17305.1 - 0.039 14.3 0.6 0.26 11.7 0.2 2.5 2 1 0 2 2 2 0 AAA ATPase domain SbcCD_C PF13558.6 ELR17305.1 - 0.072 13.3 0.1 2.2 8.6 0.1 2.9 2 1 0 2 2 2 0 Putative exonuclease SbcCD, C subunit DUF3584 PF12128.8 ELR17305.1 - 0.32 8.4 0.1 0.48 7.9 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) LRR_8 PF13855.6 ELR17306.1 - 1.2e-25 89.0 45.5 5.2e-10 38.9 2.7 3.3 1 1 4 5 5 5 5 Leucine rich repeat LRR_4 PF12799.7 ELR17306.1 - 4e-12 46.1 18.7 6.5e-05 23.2 1.7 4.1 3 1 2 5 5 5 4 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 ELR17306.1 - 0.037 14.6 10.4 11 7.1 0.0 5.7 4 1 1 5 5 5 0 Leucine Rich Repeat LRR_9 PF14580.6 ELR17306.1 - 0.065 12.7 4.4 0.23 11.0 0.7 2.4 1 1 2 3 3 3 0 Leucine-rich repeat CH PF00307.31 ELR17307.1 - 0.068 13.4 0.0 0.099 12.8 0.0 1.2 1 0 0 1 1 1 0 Calponin homology (CH) domain RhoGAP PF00620.27 ELR17308.1 - 2.7e-32 111.7 0.0 8.2e-32 110.1 0.0 1.9 1 0 0 1 1 1 1 RhoGAP domain RBD-FIP PF09457.10 ELR17309.1 - 0.085 12.8 0.0 0.19 11.7 0.0 1.6 1 0 0 1 1 1 0 FIP domain mit_SMPDase PF14724.6 ELR17310.1 - 9e-05 20.7 0.2 0.0002 19.5 0.2 1.7 1 1 0 1 1 1 1 Mitochondrial-associated sphingomyelin phosphodiesterase ATG13 PF10033.9 ELR17311.1 - 6.5e-12 45.7 0.0 9.4e-12 45.1 0.0 1.2 1 0 0 1 1 1 1 Autophagy-related protein 13 Med22 PF06179.12 ELR17311.1 - 0.06 13.6 0.0 0.11 12.7 0.0 1.3 1 0 0 1 1 1 0 Surfeit locus protein 5 subunit 22 of Mediator complex Kelch_3 PF13415.6 ELR17312.1 - 1.3e-41 140.1 19.3 1.6e-09 37.8 0.1 7.1 6 1 0 6 6 6 5 Galactose oxidase, central domain Kelch_6 PF13964.6 ELR17312.1 - 2.1e-33 113.5 13.9 1.1e-06 28.7 0.1 6.7 5 1 1 6 6 6 6 Kelch motif Kelch_4 PF13418.6 ELR17312.1 - 4.4e-30 103.4 13.6 4.4e-06 26.6 0.3 6.7 6 1 0 6 6 6 6 Galactose oxidase, central domain Kelch_1 PF01344.25 ELR17312.1 - 9.8e-30 101.9 16.9 7.5e-06 25.4 0.1 6.8 7 0 0 7 7 7 6 Kelch motif Kelch_5 PF13854.6 ELR17312.1 - 6e-27 93.1 14.9 9.6e-06 25.5 0.1 6.7 6 0 0 6 6 6 6 Kelch motif Kelch_2 PF07646.15 ELR17312.1 - 5.3e-21 73.7 16.0 0.0005 19.9 0.1 6.6 6 0 0 6 6 6 5 Kelch motif BTB PF00651.31 ELR17312.1 - 1.7e-08 34.7 0.0 2.5e-07 30.9 0.0 2.3 2 0 0 2 2 2 1 BTB/POZ domain GREB1 PF15782.5 ELR17312.1 - 0.052 10.7 0.4 0.065 10.4 0.4 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer CRAL_TRIO PF00650.20 ELR17313.1 - 6.2e-34 117.0 0.0 8.9e-34 116.5 0.0 1.2 1 0 0 1 1 1 1 CRAL/TRIO domain GOLD_2 PF13897.6 ELR17313.1 - 1e-06 29.3 1.4 0.0016 19.0 0.2 2.7 1 1 1 2 2 2 2 Golgi-dynamics membrane-trafficking CRAL_TRIO_2 PF13716.6 ELR17313.1 - 0.00012 22.3 0.0 0.0002 21.5 0.0 1.3 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain DUF4384 PF14326.6 ELR17313.1 - 0.17 12.0 0.0 0.34 11.1 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4384) DHHC PF01529.20 ELR17315.1 - 1.2e-26 93.4 9.1 1.2e-26 93.4 9.1 1.6 2 0 0 2 2 2 1 DHHC palmitoyltransferase GST_C_3 PF14497.6 ELR17317.1 - 0.00032 20.8 0.1 0.0024 18.1 0.0 2.1 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 ELR17317.1 - 0.0017 18.7 0.0 0.0081 16.5 0.0 2.2 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain T3SS_ExsE PF18286.1 ELR17317.1 - 0.0083 16.0 0.0 0.06 13.3 0.0 2.2 2 0 0 2 2 2 1 Type III secretion system ExsE APH PF01636.23 ELR17318.1 - 1.1e-18 68.0 4.9 1.1e-18 68.0 4.9 2.9 2 2 0 2 2 2 1 Phosphotransferase enzyme family Acetyltransf_7 PF13508.7 ELR17318.1 - 0.075 13.5 0.0 0.26 11.8 0.0 1.9 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 ELR17318.1 - 0.13 12.5 0.0 0.34 11.2 0.0 1.7 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family SelP_N PF04592.14 ELR17318.1 - 0.14 11.6 20.4 0.31 10.4 20.4 1.5 1 0 0 1 1 1 0 Selenoprotein P, N terminal region RskA PF10099.9 ELR17318.1 - 0.62 10.3 9.7 4.6 7.5 9.7 2.4 1 1 0 1 1 1 0 Anti-sigma-K factor rskA SUIM_assoc PF16619.5 ELR17318.1 - 3.3 7.8 5.9 1.1 9.4 0.0 2.6 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 DUF2796 PF10986.8 ELR17318.1 - 4.5 7.2 20.8 10 6.1 20.8 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2796) Herpes_capsid PF06112.11 ELR17319.1 - 5.8 7.0 10.8 13 5.8 10.8 1.5 1 0 0 1 1 1 0 Gammaherpesvirus capsid protein WD40 PF00400.32 ELR17320.1 - 0.029 15.2 0.6 0.49 11.4 0.0 3.2 3 0 0 3 3 3 0 WD domain, G-beta repeat Bd3614-deam PF14439.6 ELR17320.1 - 0.1 12.7 1.5 0.24 11.5 1.5 1.6 1 0 0 1 1 1 0 Bd3614-like deaminase FMO-like PF00743.19 ELR17322.1 - 5.3e-51 173.6 0.0 9.5e-28 96.9 0.0 3.3 3 0 0 3 3 3 3 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 ELR17322.1 - 3.3e-16 59.4 0.0 1.2e-08 34.6 0.0 2.3 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 ELR17322.1 - 2.9e-11 43.2 0.1 1.8e-10 40.5 0.1 1.9 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 ELR17322.1 - 1e-08 35.2 6.1 1.5e-08 34.7 0.3 3.3 3 0 0 3 3 3 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 ELR17322.1 - 5.5e-06 25.7 0.6 1.2e-05 24.6 0.6 1.5 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.24 ELR17322.1 - 2.3e-05 24.2 1.1 0.00082 19.1 0.0 3.3 4 0 0 4 4 4 1 FAD dependent oxidoreductase HI0933_like PF03486.14 ELR17322.1 - 5.7e-05 22.0 1.2 0.00015 20.6 0.0 1.9 2 0 0 2 2 2 1 HI0933-like protein Thi4 PF01946.17 ELR17322.1 - 7.8e-05 22.0 1.4 0.0036 16.6 0.2 2.1 2 0 0 2 2 2 1 Thi4 family Pyr_redox PF00070.27 ELR17322.1 - 0.00044 20.8 3.4 0.019 15.5 0.5 2.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase 2-Hacid_dh_C PF02826.19 ELR17322.1 - 0.0032 16.8 0.0 1.1 8.6 0.0 2.5 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Amino_oxidase PF01593.24 ELR17322.1 - 0.0083 15.5 0.0 0.011 15.0 0.0 1.3 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase K_oxygenase PF13434.6 ELR17322.1 - 0.01 15.0 0.3 0.21 10.7 0.0 2.8 3 0 0 3 3 3 0 L-lysine 6-monooxygenase (NADPH-requiring) IlvN PF07991.12 ELR17322.1 - 0.015 14.8 0.3 0.039 13.5 0.0 1.7 2 0 0 2 2 2 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain NAD_Gly3P_dh_N PF01210.23 ELR17322.1 - 0.02 14.9 0.0 0.038 14.0 0.0 1.4 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus FAD_binding_3 PF01494.19 ELR17322.1 - 0.025 13.8 0.1 0.055 12.7 0.1 1.4 1 0 0 1 1 1 0 FAD binding domain 3HCDH_N PF02737.18 ELR17322.1 - 0.031 14.2 0.1 0.064 13.1 0.1 1.5 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain GIDA PF01134.22 ELR17322.1 - 0.064 12.3 0.3 0.12 11.5 0.3 1.4 1 0 0 1 1 1 0 Glucose inhibited division protein A AlaDh_PNT_C PF01262.21 ELR17322.1 - 2.3 7.5 6.4 0.073 12.4 0.3 1.5 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain Lycopene_cycl PF05834.12 ELR17322.1 - 3.5 6.6 5.2 1.2 8.1 0.0 2.3 3 0 0 3 3 3 0 Lycopene cyclase protein Actin PF00022.19 ELR17323.1 - 2.2e-101 339.4 0.0 2.7e-101 339.1 0.0 1.1 1 0 0 1 1 1 1 Actin MreB_Mbl PF06723.13 ELR17323.1 - 0.0013 17.6 0.0 0.46 9.2 0.0 2.2 2 0 0 2 2 2 2 MreB/Mbl protein MM_CoA_mutase PF01642.22 ELR17324.1 - 1.9e-210 699.8 5.2 2.7e-131 438.6 0.0 2.0 1 1 1 2 2 2 2 Methylmalonyl-CoA mutase B12-binding PF02310.19 ELR17324.1 - 2.4e-15 56.6 0.3 6.2e-15 55.3 0.3 1.7 1 0 0 1 1 1 1 B12 binding domain PhnI PF05861.12 ELR17324.1 - 0.0026 16.7 0.0 0.0049 15.8 0.0 1.3 1 0 0 1 1 1 1 Bacterial phosphonate metabolism protein (PhnI) TPR_2 PF07719.17 ELR17326.1 - 6.3e-09 35.3 0.4 0.0072 16.4 0.1 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_9 PF13371.6 ELR17326.1 - 9.1e-07 28.9 5.1 0.00034 20.7 1.3 2.5 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_11 PF13414.6 ELR17326.1 - 7.5e-06 25.5 0.1 0.00095 18.8 0.0 3.0 1 1 2 3 3 3 1 TPR repeat TPR_16 PF13432.6 ELR17326.1 - 5.7e-05 23.7 7.5 0.0024 18.5 3.1 2.5 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.28 ELR17326.1 - 6.4e-05 22.6 0.0 1.2 9.1 0.0 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.6 ELR17326.1 - 0.0008 20.0 1.3 2.2 9.3 0.5 3.1 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_19 PF14559.6 ELR17326.1 - 0.027 15.0 1.3 0.19 12.3 0.5 2.3 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_17 PF13431.6 ELR17326.1 - 0.063 13.7 0.1 5.4 7.6 0.0 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat NAD_binding_8 PF13450.6 ELR17328.1 - 2.1e-12 47.1 0.5 1.5e-11 44.3 0.5 2.3 1 1 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Amino_oxidase PF01593.24 ELR17328.1 - 4.2e-07 29.6 0.5 0.00015 21.2 0.0 2.7 2 1 0 2 2 2 2 Flavin containing amine oxidoreductase FAD_binding_2 PF00890.24 ELR17328.1 - 2.3e-05 23.7 0.9 3.5e-05 23.1 0.9 1.3 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 ELR17328.1 - 4.2e-05 22.9 0.0 6.1e-05 22.4 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 ELR17328.1 - 0.00012 21.8 2.2 0.00019 21.1 1.9 1.6 1 1 0 1 1 1 1 FAD dependent oxidoreductase HI0933_like PF03486.14 ELR17328.1 - 0.00044 19.1 0.4 0.00064 18.5 0.4 1.2 1 0 0 1 1 1 1 HI0933-like protein 3HCDH_N PF02737.18 ELR17328.1 - 0.00071 19.5 0.0 0.0011 18.8 0.0 1.3 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain FMO-like PF00743.19 ELR17328.1 - 0.00076 18.0 0.0 0.0011 17.5 0.0 1.1 1 0 0 1 1 1 1 Flavin-binding monooxygenase-like NAD_binding_9 PF13454.6 ELR17328.1 - 0.00085 19.3 0.2 0.0026 17.8 0.1 2.0 2 1 1 3 3 3 1 FAD-NAD(P)-binding GIDA PF01134.22 ELR17328.1 - 0.0031 16.7 0.1 0.0043 16.2 0.1 1.1 1 0 0 1 1 1 1 Glucose inhibited division protein A FAD_binding_3 PF01494.19 ELR17328.1 - 0.0033 16.7 0.3 0.0049 16.2 0.3 1.2 1 0 0 1 1 1 1 FAD binding domain Thi4 PF01946.17 ELR17328.1 - 0.0064 15.8 0.2 0.012 14.9 0.2 1.3 1 0 0 1 1 1 1 Thi4 family Pyr_redox PF00070.27 ELR17328.1 - 0.0071 16.9 0.5 0.018 15.6 0.2 1.8 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase AlaDh_PNT_C PF01262.21 ELR17328.1 - 0.0071 15.7 0.2 0.012 14.9 0.2 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain ApbA PF02558.16 ELR17328.1 - 0.028 14.1 0.0 0.47 10.1 0.0 2.1 2 0 0 2 2 2 0 Ketopantoate reductase PanE/ApbA FAD_oxidored PF12831.7 ELR17328.1 - 0.099 12.0 0.1 0.13 11.6 0.1 1.2 1 0 0 1 1 1 0 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 ELR17328.1 - 0.12 11.7 0.0 0.14 11.3 0.0 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase adh_short_C2 PF13561.6 ELR17332.1 - 2.2e-49 168.2 5.1 3.6e-26 92.1 0.0 3.0 1 1 1 2 2 2 2 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 ELR17332.1 - 5e-38 130.5 7.0 5.3e-35 120.7 7.0 3.0 1 1 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 ELR17332.1 - 1.6e-09 37.9 0.2 2.7e-09 37.2 0.2 1.4 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 ELR17332.1 - 0.014 14.9 0.2 0.092 12.2 0.1 2.0 2 0 0 2 2 2 0 NAD dependent epimerase/dehydratase family Shikimate_DH PF01488.20 ELR17332.1 - 0.22 11.6 1.0 0.34 11.0 0.3 1.6 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase SF1-HH PF16275.5 ELR17334.1 - 5.9e-34 116.8 0.0 1e-33 116.1 0.0 1.4 1 0 0 1 1 1 1 Splicing factor 1 helix-hairpin domain KH_1 PF00013.29 ELR17334.1 - 4.4e-09 36.0 0.3 7.7e-09 35.3 0.3 1.4 1 0 0 1 1 1 1 KH domain SIS PF01380.22 ELR17335.1 - 3.2e-39 133.8 1.0 1e-19 70.7 0.0 2.5 2 0 0 2 2 2 2 SIS domain GATase_6 PF13522.6 ELR17335.1 - 4.2e-23 82.0 0.2 1.1e-22 80.7 0.2 1.8 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_7 PF13537.6 ELR17335.1 - 1.3e-17 63.8 0.0 2.5e-17 62.9 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_4 PF13230.6 ELR17335.1 - 0.004 16.1 0.6 0.04 12.8 0.2 2.3 2 0 0 2 2 2 1 Glutamine amidotransferases class-II Fer4_5 PF12801.7 ELR17336.1 - 5.7e-17 61.4 8.5 7e-12 45.1 1.2 3.6 4 0 0 4 4 4 2 4Fe-4S binding domain Fer4_9 PF13187.6 ELR17336.1 - 0.012 15.8 1.3 0.092 12.9 0.8 2.5 2 1 0 2 2 2 0 4Fe-4S dicluster domain Fer4_13 PF13370.6 ELR17336.1 - 0.019 15.5 0.5 0.019 15.5 0.5 2.0 2 0 0 2 2 2 0 4Fe-4S single cluster domain of Ferredoxin I Fer4_7 PF12838.7 ELR17336.1 - 0.032 14.8 2.8 0.22 12.2 2.2 2.4 2 1 0 2 2 2 0 4Fe-4S dicluster domain Fer4_6 PF12837.7 ELR17336.1 - 0.049 13.7 0.7 0.049 13.7 0.7 2.9 3 0 0 3 3 3 0 4Fe-4S binding domain Fer4_15 PF13459.6 ELR17336.1 - 0.053 14.3 0.2 0.12 13.2 0.2 1.5 1 0 0 1 1 1 0 4Fe-4S single cluster domain Fer4_10 PF13237.6 ELR17336.1 - 0.14 12.3 5.4 0.12 12.5 0.9 2.8 3 1 1 4 4 4 0 4Fe-4S dicluster domain Fer4_2 PF12797.7 ELR17336.1 - 0.2 11.9 0.5 0.2 11.9 0.5 3.1 4 0 0 4 4 3 0 4Fe-4S binding domain Fer4 PF00037.27 ELR17336.1 - 0.21 11.5 8.5 0.21 11.5 0.5 3.6 4 0 0 4 4 4 0 4Fe-4S binding domain Fer4_18 PF13746.6 ELR17336.1 - 0.21 11.8 4.0 3.9 7.7 2.5 2.7 2 1 0 2 2 2 0 4Fe-4S dicluster domain Fer4_21 PF14697.6 ELR17336.1 - 0.37 10.9 0.2 0.37 10.9 0.2 2.3 3 0 0 3 3 3 0 4Fe-4S dicluster domain Fer4_17 PF13534.6 ELR17336.1 - 1.4 9.5 3.9 2.3 8.8 2.3 2.2 2 1 0 2 2 2 0 4Fe-4S dicluster domain Arf PF00025.21 ELR17337.1 - 4.9e-71 237.8 0.2 5.5e-71 237.6 0.2 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 ELR17337.1 - 1.6e-11 44.4 0.0 2.2e-11 44.0 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 ELR17337.1 - 1.5e-10 41.0 0.0 1.7e-10 40.7 0.0 1.1 1 0 0 1 1 1 1 Ras family G-alpha PF00503.20 ELR17337.1 - 1.5e-10 40.8 1.1 5e-06 25.9 0.1 2.1 1 1 1 2 2 2 2 G-protein alpha subunit SRPRB PF09439.10 ELR17337.1 - 3.3e-09 36.4 0.0 4.2e-09 36.1 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 ELR17337.1 - 5.6e-07 29.6 0.0 8.4e-07 29.1 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 ELR17337.1 - 5e-06 26.1 0.0 5.8e-06 25.8 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region TniB PF05621.11 ELR17337.1 - 0.092 12.1 0.0 0.14 11.5 0.0 1.2 1 0 0 1 1 1 0 Bacterial TniB protein Pkinase PF00069.25 ELR17338.1 - 4.7e-55 186.8 0.0 7.4e-55 186.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR17338.1 - 1.5e-30 106.3 0.0 2.3e-30 105.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase PH_3 PF14593.6 ELR17338.1 - 6.4e-22 77.6 0.1 1.4e-21 76.6 0.1 1.5 1 0 0 1 1 1 1 PH domain Kinase-like PF14531.6 ELR17338.1 - 1.8e-06 27.5 0.0 4e-06 26.3 0.0 1.6 1 1 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 ELR17338.1 - 0.00032 19.6 0.0 0.00032 19.6 0.0 3.0 3 0 0 3 3 3 1 Fungal protein kinase APH PF01636.23 ELR17338.1 - 0.0038 17.2 1.1 0.0072 16.3 0.0 2.0 2 0 0 2 2 2 1 Phosphotransferase enzyme family FTA2 PF13095.6 ELR17338.1 - 0.011 15.4 0.1 0.084 12.5 0.0 2.3 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Kdo PF06293.14 ELR17338.1 - 0.024 14.0 0.0 0.045 13.1 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family PH PF00169.29 ELR17338.1 - 0.049 14.1 0.1 0.19 12.2 0.0 2.1 2 0 0 2 2 2 0 PH domain DUF4611 PF15387.6 ELR17338.1 - 0.18 12.1 3.1 0.58 10.4 3.1 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF4611) Exo_endo_phos PF03372.23 ELR17339.1 - 3.5e-16 59.4 0.1 5.5e-16 58.8 0.1 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Peptidase_M19 PF01244.21 ELR17340.1 - 2.3e-114 381.9 0.0 2.7e-114 381.6 0.0 1.0 1 0 0 1 1 1 1 Membrane dipeptidase (Peptidase family M19) Amidohydro_2 PF04909.14 ELR17340.1 - 0.062 13.1 0.0 0.29 10.9 0.0 2.0 2 1 0 2 2 2 0 Amidohydrolase MARVEL PF01284.23 ELR17341.1 - 0.00043 20.3 13.0 0.00046 20.2 11.5 1.7 1 1 1 2 2 2 1 Membrane-associating domain Peptidase_U4 PF03419.13 ELR17341.1 - 0.32 10.3 5.0 0.66 9.2 5.0 1.5 1 1 0 1 1 1 0 Sporulation factor SpoIIGA DUF2070 PF09843.9 ELR17341.1 - 3.4 5.9 8.6 4.4 5.5 8.6 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) DUF4658 PF15555.6 ELR17341.1 - 4.9 7.3 5.8 0.37 10.9 0.5 1.9 2 1 0 2 2 2 0 Domain of unknown function (DUF4658) DUF5518 PF17647.1 ELR17341.1 - 7 6.8 30.6 0.072 13.2 6.9 3.0 3 0 0 3 3 3 0 Family of unknown function (DUF5518) MARVEL PF01284.23 ELR17342.1 - 2.7e-06 27.5 10.3 5.1e-06 26.6 10.3 1.6 1 1 0 1 1 1 1 Membrane-associating domain DUF4064 PF13273.6 ELR17342.1 - 0.78 10.1 15.6 0.31 11.3 0.7 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF4064) Heliorhodopsin PF18761.1 ELR17342.1 - 1.6 8.0 6.1 0.078 12.3 0.5 1.6 2 0 0 2 2 2 0 Heliorhodopsin DUF4834 PF16118.5 ELR17343.1 - 0.54 11.3 0.0 0.54 11.3 0.0 2.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4834) DUF4781 PF16013.5 ELR17343.1 - 0.82 8.4 6.0 0.48 9.2 3.8 1.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4781) VKOR PF07884.14 ELR17343.1 - 1.8 8.8 11.1 0.52 10.5 4.8 2.2 2 0 0 2 2 2 0 Vitamin K epoxide reductase family GMC_oxred_N PF00732.19 ELR17344.1 - 1.5e-48 165.7 0.0 1.8e-48 165.4 0.0 1.1 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 ELR17344.1 - 9e-26 91.1 0.0 1.5e-25 90.4 0.0 1.3 1 0 0 1 1 1 1 GMC oxidoreductase XRN_N PF03159.18 ELR17348.1 - 0.00047 19.7 1.7 0.00096 18.6 1.7 1.4 1 0 0 1 1 1 1 XRN 5'-3' exonuclease N-terminus DUF4820 PF16091.5 ELR17348.1 - 0.77 9.1 5.9 2.4 7.5 5.9 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) ubiquitin PF00240.23 ELR17350.1 - 6.2e-102 333.4 14.4 2.7e-34 116.8 0.7 3.0 2 1 1 3 3 3 3 Ubiquitin family Rad60-SLD PF11976.8 ELR17350.1 - 3.7e-49 164.4 13.9 2.1e-16 59.5 0.8 3.0 2 1 1 3 3 3 3 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 ELR17350.1 - 2e-19 69.8 6.2 6.5e-05 23.3 0.2 4.6 2 2 1 3 3 3 3 Ubiquitin-like domain TBK1_ULD PF18396.1 ELR17350.1 - 3.4e-13 49.3 1.6 0.0087 16.0 0.0 3.3 2 1 1 3 3 3 3 TANK binding kinase 1 ubiquitin-like domain DUF2407 PF10302.9 ELR17350.1 - 3.1e-12 47.0 0.4 0.031 14.8 0.0 3.1 1 1 2 3 3 3 3 DUF2407 ubiquitin-like domain Rad60-SLD_2 PF13881.6 ELR17350.1 - 1.5e-11 44.4 2.3 0.032 14.3 0.1 4.0 2 2 1 3 3 3 3 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_5 PF18037.1 ELR17350.1 - 4.4e-11 43.0 5.8 0.014 15.8 0.2 3.1 1 1 2 3 3 3 3 Ubiquitin-like domain DUF3861 PF12977.7 ELR17350.1 - 4.5e-06 26.7 1.5 2.4 8.4 0.0 3.2 3 0 0 3 3 3 3 Domain of Unknown Function with PDB structure (DUF3861) Ubiquitin_4 PF18036.1 ELR17350.1 - 7.9e-06 25.8 16.7 4.7 7.3 0.2 6.0 5 1 1 6 6 6 2 Ubiquitin-like domain Sde2_N_Ubi PF13019.6 ELR17350.1 - 3.2e-05 23.8 0.1 0.8 9.5 0.0 3.1 2 1 1 3 3 3 2 Silencing defective 2 N-terminal ubiquitin domain DUF2870 PF11069.8 ELR17350.1 - 0.0012 19.1 0.0 31 5.0 0.0 3.6 3 0 0 3 3 3 0 Protein of unknown function (DUF2870) Raf1_HTH PF18579.1 ELR17350.1 - 0.0019 17.9 0.5 24 4.7 0.0 3.3 3 0 0 3 3 3 0 Rubisco accumulation factor 1 helix turn helix domain Big_3_3 PF13750.6 ELR17350.1 - 0.0022 17.7 0.2 6.3 6.4 0.1 3.1 2 1 1 3 3 3 0 Bacterial Ig-like domain (group 3) ACT_5 PF13710.6 ELR17350.1 - 0.0035 17.2 3.8 12 5.8 0.1 3.3 3 0 0 3 3 3 0 ACT domain ACT_4 PF13291.6 ELR17350.1 - 0.0044 17.6 0.9 38 5.0 0.1 3.3 3 0 0 3 3 3 0 ACT domain DUF493 PF04359.14 ELR17350.1 - 0.0051 17.4 0.1 48 4.6 0.0 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF493) Big_7 PF17957.1 ELR17350.1 - 0.0065 17.2 0.0 60 4.5 0.0 3.1 3 0 0 3 3 3 0 Bacterial Ig domain DUF1866 PF08952.11 ELR17350.1 - 0.007 16.2 0.3 32 4.4 0.0 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF1866) Plexin_cytopl PF08337.12 ELR17350.1 - 0.0077 15.0 11.1 0.46 9.1 0.2 4.0 3 1 1 5 5 5 2 Plexin cytoplasmic RasGAP domain RBD PF02196.15 ELR17350.1 - 0.0095 16.0 0.0 51 4.1 0.0 3.3 3 0 0 3 3 3 0 Raf-like Ras-binding domain ProRS-C_2 PF09181.10 ELR17350.1 - 0.041 14.0 3.7 39 4.5 0.1 3.2 3 0 0 3 3 3 0 Prolyl-tRNA synthetase, C-terminal UDP-g_GGTase PF06427.11 ELR17350.1 - 0.048 13.8 2.5 2.9 8.0 0.1 3.2 3 0 0 3 3 3 0 UDP-glucose:Glycoprotein Glucosyltransferase Coagulin PF02035.15 ELR17350.1 - 0.052 13.4 1.7 38 4.1 0.0 3.1 3 0 0 3 3 3 0 Coagulin Acp26Ab PF05777.12 ELR17350.1 - 0.072 13.7 2.4 6.6 7.4 0.0 4.0 4 1 0 4 4 4 0 Drosophila accessory gland-specific peptide 26Ab (Acp26Ab) YukD PF08817.10 ELR17350.1 - 0.088 13.5 0.1 1.3e+02 3.4 0.0 3.2 3 0 0 3 3 3 0 WXG100 protein secretion system (Wss), protein YukD PI3K_p85B PF02192.16 ELR17350.1 - 0.1 12.3 7.0 20 5.0 0.2 3.3 3 0 0 3 3 3 0 PI3-kinase family, p85-binding domain Tash_PEST PF07708.11 ELR17350.1 - 0.12 12.6 18.4 4.3 7.6 1.5 3.3 3 0 0 3 3 3 0 Tash protein PEST motif Phage_sheath_1N PF17481.2 ELR17350.1 - 0.24 11.9 4.0 97 3.5 4.0 3.0 1 1 0 1 1 1 0 Phage tail sheath protein beta-sandwich domain Myosin_N PF02736.19 ELR17350.1 - 1.4 8.8 4.1 72 3.3 0.0 3.9 3 0 0 3 3 3 0 Myosin N-terminal SH3-like domain RasGEF PF00617.19 ELR17351.1 - 5.2e-48 163.6 0.2 1e-47 162.6 0.2 1.5 1 0 0 1 1 1 1 RasGEF domain V4R PF02830.18 ELR17351.1 - 2.2e-13 50.0 1.5 8.9e-06 25.6 0.1 3.0 2 1 0 2 2 2 2 V4R domain Ndc1_Nup PF09531.10 ELR17351.1 - 0.79 8.3 5.0 2 7.0 5.0 1.7 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup CsbD PF05532.12 ELR17352.1 - 0.021 14.7 1.4 0.038 13.9 1.4 1.4 1 0 0 1 1 1 0 CsbD-like Suppressor_APC PF11414.8 ELR17352.1 - 0.023 14.8 0.0 1.2e+02 2.9 0.0 4.4 4 1 0 4 4 4 0 Adenomatous polyposis coli tumour suppressor protein Sugar_tr PF00083.24 ELR17354.1 - 6.1e-86 289.1 29.4 1.7e-48 165.6 8.0 3.4 2 2 0 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 ELR17354.1 - 1.1e-26 93.6 29.5 3.6e-21 75.5 14.3 3.4 1 1 2 3 3 3 3 Major Facilitator Superfamily DnaG_DnaB_bind PF08278.11 ELR17354.1 - 0.13 12.9 0.9 0.26 11.9 0.9 1.4 1 0 0 1 1 1 0 DNA primase DnaG DnaB-binding RFX_DNA_binding PF02257.15 ELR17355.1 - 2.8e-19 69.5 0.0 5.5e-19 68.6 0.0 1.5 1 0 0 1 1 1 1 RFX DNA-binding domain Sporozoite_P67 PF05642.11 ELR17355.1 - 0.0031 15.7 2.8 0.0031 15.7 2.8 2.9 3 0 0 3 3 2 1 Sporozoite P67 surface antigen Nop14 PF04147.12 ELR17355.1 - 0.096 10.9 8.3 0.14 10.4 8.3 1.1 1 0 0 1 1 1 0 Nop14-like family PBP1_TM PF14812.6 ELR17355.1 - 0.11 12.9 13.9 0.21 12.0 13.9 1.4 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal RMI1_N PF08585.12 ELR17355.1 - 0.2 11.4 0.0 0.45 10.2 0.0 1.6 1 0 0 1 1 1 0 RecQ mediated genome instability protein RXT2_N PF08595.11 ELR17355.1 - 0.2 11.7 2.8 0.34 10.9 2.8 1.3 1 0 0 1 1 1 0 RXT2-like, N-terminal BUD22 PF09073.10 ELR17355.1 - 0.28 10.5 9.0 0.52 9.6 9.0 1.3 1 0 0 1 1 1 0 BUD22 CDC45 PF02724.14 ELR17355.1 - 0.33 9.2 7.3 0.44 8.8 7.3 1.1 1 0 0 1 1 1 0 CDC45-like protein RNA_pol_3_Rpc31 PF11705.8 ELR17355.1 - 0.49 10.6 17.9 0.46 10.7 14.0 2.4 2 0 0 2 2 2 0 DNA-directed RNA polymerase III subunit Rpc31 PGA2 PF07543.12 ELR17355.1 - 0.55 10.2 8.5 1 9.4 8.5 1.3 1 0 0 1 1 1 0 Protein trafficking PGA2 NOA36 PF06524.12 ELR17355.1 - 0.67 9.2 14.3 1.3 8.3 14.3 1.4 1 0 0 1 1 1 0 NOA36 protein Sigma70_ner PF04546.13 ELR17355.1 - 1 9.2 5.6 1.7 8.5 5.6 1.3 1 0 0 1 1 1 0 Sigma-70, non-essential region GCIP PF13324.6 ELR17355.1 - 1.4 8.5 3.6 2.6 7.6 3.6 1.4 1 0 0 1 1 1 0 Grap2 and cyclin-D-interacting FAM176 PF14851.6 ELR17355.1 - 1.5 8.5 4.6 3.2 7.4 4.6 1.5 1 0 0 1 1 1 0 FAM176 family Cwf_Cwc_15 PF04889.12 ELR17355.1 - 2.6 7.7 13.1 4.2 7.0 13.1 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein CENP-B_dimeris PF09026.10 ELR17355.1 - 3.6 8.0 16.5 7 7.1 16.5 1.4 1 0 0 1 1 1 0 Centromere protein B dimerisation domain HEXIM PF15313.6 ELR17355.1 - 4.6 7.4 10.5 12 6.1 0.0 2.7 3 0 0 3 3 3 0 Hexamethylene bis-acetamide-inducible protein Mito_carr PF00153.27 ELR17356.1 - 0.00019 21.3 0.1 0.013 15.4 0.0 2.8 2 1 1 3 3 3 1 Mitochondrial carrier protein Phenol_monoox PF04663.12 ELR17356.1 - 0.057 13.6 0.1 0.14 12.3 0.1 1.6 1 0 0 1 1 1 0 Phenol hydroxylase conserved region ABC_trans_CmpB PF06541.11 ELR17357.1 - 0.00015 22.1 2.0 0.00029 21.1 2.0 1.4 1 0 0 1 1 1 1 Putative ABC-transporter type IV RGS12_us2 PF16611.5 ELR17357.1 - 0.21 12.0 0.7 0.44 11.0 0.7 1.4 1 0 0 1 1 1 0 Unstructured region between RBD and GoLoco DnaJ PF00226.31 ELR17358.1 - 4.2e-11 42.8 0.0 1.4e-10 41.2 0.0 1.9 1 0 0 1 1 1 1 DnaJ domain FAM199X PF15814.5 ELR17358.1 - 1.1 8.3 12.9 1.8 7.5 12.9 1.3 1 0 0 1 1 1 0 Protein family FAM199X Cdh1_DBD_1 PF18196.1 ELR17358.1 - 1.3 9.4 16.6 0.15 12.4 9.4 2.3 2 0 0 2 2 2 0 Chromodomain helicase DNA-binding domain 1 FYDLN_acid PF09538.10 ELR17358.1 - 2.1 9.0 12.5 2.4 8.9 7.9 2.4 2 0 0 2 2 2 0 Protein of unknown function (FYDLN_acid) RPN2_C PF18004.1 ELR17358.1 - 2.4 8.0 22.6 0.34 10.8 13.5 2.2 2 0 0 2 2 2 0 26S proteasome regulatory subunit RPN2 C-terminal domain DUF1764 PF08576.10 ELR17358.1 - 6.1 7.8 17.1 5.9 7.9 9.0 2.7 2 0 0 2 2 2 0 Eukaryotic protein of unknown function (DUF1764) IFRD PF05004.13 ELR17359.1 - 4.6e-09 35.8 0.1 7.8e-09 35.1 0.1 1.3 1 0 0 1 1 1 1 Interferon-related developmental regulator (IFRD) DUF1318 PF07027.12 ELR17360.1 - 0.13 12.7 0.0 7.4 7.1 0.0 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF1318) Pur_ac_phosph_N PF16656.5 ELR17361.1 - 1.5e-21 76.7 0.1 3.8e-21 75.5 0.1 1.7 1 0 0 1 1 1 1 Purple acid Phosphatase, N-terminal domain Metallophos PF00149.28 ELR17361.1 - 2e-17 64.4 0.1 6.8e-17 62.6 0.1 1.8 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_C PF14008.6 ELR17361.1 - 2.6e-14 53.8 0.0 7.4e-14 52.4 0.0 1.9 1 0 0 1 1 1 1 Iron/zinc purple acid phosphatase-like protein C PhoD_N PF16655.5 ELR17361.1 - 0.0026 18.2 0.0 0.012 16.1 0.0 2.2 1 0 0 1 1 1 1 PhoD-like phosphatase, N-terminal domain ASC PF00858.24 ELR17362.1 - 5.6e-10 38.8 1.1 1.2e-07 31.1 0.2 2.1 1 1 1 2 2 2 2 Amiloride-sensitive sodium channel zf-Tim10_DDP PF02953.15 ELR17363.1 - 2.1e-20 72.1 1.6 2.8e-20 71.7 1.6 1.2 1 0 0 1 1 1 1 Tim10/DDP family zinc finger DUF842 PF05811.13 ELR17363.1 - 0.037 13.7 4.5 0.11 12.1 4.4 1.7 1 1 0 1 1 1 0 Eukaryotic protein of unknown function (DUF842) EMP24_GP25L PF01105.24 ELR17364.1 - 5.3e-35 121.0 0.0 6.3e-35 120.8 0.0 1.1 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD GFO_IDH_MocA PF01408.22 ELR17366.1 - 4.8e-17 62.9 0.0 8.7e-17 62.1 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.17 ELR17366.1 - 8.9e-09 35.4 0.0 2e-08 34.2 0.0 1.7 1 1 0 1 1 1 1 Oxidoreductase family, C-terminal alpha/beta domain CBM49 PF09478.10 ELR17367.1 - 4.3e-23 81.4 4.5 1.4e-12 47.7 0.3 3.2 3 0 0 3 3 3 3 Carbohydrate binding domain CBM49 CBM_2 PF00553.19 ELR17367.1 - 9.6e-11 41.9 21.6 8.4e-06 26.0 2.1 4.6 3 2 2 5 5 5 3 Cellulose binding domain DUF11 PF01345.18 ELR17367.1 - 0.0004 20.6 0.2 4.8 7.5 0.3 4.0 1 1 2 3 3 3 2 Domain of unknown function DUF11 S-methyl_trans PF02574.16 ELR17368.1 - 1.6e-54 185.6 0.0 1.9e-54 185.3 0.0 1.0 1 0 0 1 1 1 1 Homocysteine S-methyltransferase MMR_HSR1_Xtn PF16897.5 ELR17370.1 - 4.3e-42 142.5 0.1 8.1e-42 141.6 0.1 1.5 1 0 0 1 1 1 1 C-terminal region of MMR_HSR1 domain TGS PF02824.21 ELR17370.1 - 8.2e-24 83.4 0.1 2.1e-23 82.1 0.0 1.8 2 0 0 2 2 2 1 TGS domain MMR_HSR1 PF01926.23 ELR17370.1 - 9.5e-18 64.3 0.0 2e-17 63.3 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 ELR17370.1 - 1.8e-08 34.1 0.1 4.6e-08 32.7 0.0 1.7 2 0 0 2 2 2 1 Ferrous iron transport protein B MeaB PF03308.16 ELR17370.1 - 0.007 15.4 0.1 0.013 14.5 0.1 1.4 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB Dynamin_N PF00350.23 ELR17370.1 - 0.1 12.7 1.5 5.2 7.1 0.1 2.5 3 0 0 3 3 3 0 Dynamin family SRPRB PF09439.10 ELR17370.1 - 0.11 11.9 0.0 0.27 10.7 0.0 1.5 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit Glyco_hydro_47 PF01532.20 ELR17371.1 - 6e-120 401.2 0.0 9.2e-120 400.6 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 DUF4482 PF14818.6 ELR17371.1 - 0.0051 17.7 4.6 0.0097 16.8 4.6 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4482) WD40 PF00400.32 ELR17372.1 - 8.3e-12 45.4 4.9 0.3 12.0 0.1 5.5 5 1 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ELR17372.1 - 0.0015 18.8 0.1 0.011 16.0 0.0 2.3 3 0 0 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain SRF-TF PF00319.18 ELR17373.1 - 8.2e-05 22.0 0.3 0.069 12.7 0.1 2.5 2 0 0 2 2 2 2 SRF-type transcription factor (DNA-binding and dimerisation domain) Cnd2 PF05786.14 ELR17373.1 - 0.033 12.8 0.0 0.044 12.4 0.0 1.1 1 0 0 1 1 1 0 Condensin complex subunit 2 LRR_4 PF12799.7 ELR17374.1 - 3e-09 37.0 45.0 2.2 8.8 0.0 15.5 12 4 7 20 20 20 6 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 ELR17374.1 - 0.00078 19.3 44.3 1.1 9.5 0.2 15.3 19 0 0 19 19 19 3 Leucine Rich repeat TFIIA PF03153.13 ELR17374.1 - 1.4 8.8 5.9 2.9 7.8 5.9 1.4 1 1 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit RasGAP PF00616.19 ELR17375.1 - 3.6e-28 98.7 0.0 1.6e-20 73.7 0.0 2.2 1 1 1 2 2 2 2 GTPase-activator protein for Ras-like GTPase WD40 PF00400.32 ELR17376.1 - 1.1e-06 29.2 7.4 0.0094 16.8 0.0 5.4 6 0 0 6 6 6 2 WD domain, G-beta repeat SR-25 PF10500.9 ELR17376.1 - 0.00086 19.0 6.2 0.00086 19.0 6.2 2.5 2 1 0 2 2 2 2 Nuclear RNA-splicing-associated protein UCH PF00443.29 ELR17377.1 - 1.8e-37 129.3 0.0 1.1e-36 126.7 0.0 2.4 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 ELR17377.1 - 1.4e-20 74.1 0.0 4.2e-13 49.6 0.0 2.7 2 1 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase ubiquitin PF00240.23 ELR17377.1 - 1.2e-13 50.6 2.0 0.023 14.4 0.0 7.6 8 0 0 8 8 8 3 Ubiquitin family UBA PF00627.31 ELR17377.1 - 1e-05 25.3 0.3 2.6e-05 24.0 0.3 1.7 1 0 0 1 1 1 1 UBA/TS-N domain YukD PF08817.10 ELR17377.1 - 3.7e-05 24.3 1.9 1.9 9.2 0.0 4.6 3 1 0 3 3 3 1 WXG100 protein secretion system (Wss), protein YukD Ubiquitin_2 PF14560.6 ELR17377.1 - 0.00012 22.5 0.0 0.078 13.4 0.0 3.9 4 0 0 4 4 4 1 Ubiquitin-like domain Ubiquitin_4 PF18036.1 ELR17377.1 - 0.0034 17.4 0.0 36 4.5 0.0 5.1 5 0 0 5 5 5 0 Ubiquitin-like domain DZR PF12773.7 ELR17377.1 - 2.2 8.4 8.6 4.7 7.3 0.9 3.0 2 1 0 2 2 2 0 Double zinc ribbon zf-RanBP PF00641.18 ELR17377.1 - 4.7 6.6 7.2 0.34 10.3 1.7 1.9 2 0 0 2 2 2 0 Zn-finger in Ran binding protein and others WD40 PF00400.32 ELR17378.1 - 4.7e-41 138.0 18.9 7.8e-11 42.4 0.7 5.7 5 1 0 5 5 5 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ELR17378.1 - 1.2e-09 38.3 1.2 0.035 14.4 0.0 4.1 1 1 1 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ELR17378.1 - 1.2e-07 30.8 7.2 0.0045 15.7 0.0 4.6 3 1 2 5 5 5 4 Nucleoporin Nup120/160 WD40_like PF17005.5 ELR17378.1 - 0.027 13.8 0.0 0.25 10.6 0.0 2.2 2 0 0 2 2 2 0 WD40-like domain Bet_v_1 PF00407.19 ELR17378.1 - 0.083 12.8 0.0 0.43 10.5 0.0 1.9 2 0 0 2 2 2 0 Pathogenesis-related protein Bet v I family F-box-like PF12937.7 ELR17379.1 - 0.00039 20.3 0.3 0.00069 19.5 0.3 1.5 1 0 0 1 1 1 1 F-box-like TraG-D_C PF12696.7 ELR17379.1 - 0.08 12.9 0.9 0.17 11.9 0.3 1.9 2 0 0 2 2 2 0 TraM recognition site of TraD and TraG SAM_2 PF07647.17 ELR17380.1 - 5.4e-06 26.4 0.0 9.5e-06 25.6 0.0 1.3 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 ELR17380.1 - 1.2e-05 25.7 0.1 2.5e-05 24.6 0.1 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_4 PF18017.1 ELR17380.1 - 0.0026 17.7 0.0 0.0045 16.9 0.0 1.3 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Dicty_REP PF05086.12 ELR17380.1 - 0.0086 14.1 9.9 0.013 13.5 9.9 1.2 1 0 0 1 1 1 1 Dictyostelium (Slime Mold) REP protein TFIIA PF03153.13 ELR17380.1 - 0.43 10.5 27.1 0.5 10.3 10.3 2.3 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit PRMT5_C PF17286.2 ELR17381.1 - 3.6e-12 46.5 0.1 4.2e-11 43.0 0.1 2.4 1 1 0 1 1 1 1 PRMT5 oligomerisation domain PRMT5 PF05185.16 ELR17381.1 - 6.4e-10 39.2 0.0 1e-09 38.4 0.0 1.3 1 0 0 1 1 1 1 PRMT5 arginine-N-methyltransferase 5_nucleotid_C PF02872.18 ELR17382.1 - 1.6e-09 38.1 0.0 4.1e-09 36.8 0.0 1.6 1 0 0 1 1 1 1 5'-nucleotidase, C-terminal domain Metallophos PF00149.28 ELR17382.1 - 3.5e-06 27.7 0.4 1.6e-05 25.5 0.0 2.2 3 0 0 3 3 3 1 Calcineurin-like phosphoesterase 2OG-FeII_Oxy_3 PF13640.6 ELR17383.1 - 4.1e-13 50.0 0.1 1.8e-12 48.0 0.0 2.1 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy PF03171.20 ELR17383.1 - 0.05 14.1 0.1 0.15 12.5 0.1 1.9 1 1 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily TFIIE-A_C PF11521.8 ELR17383.1 - 0.063 13.6 0.2 0.12 12.7 0.2 1.4 1 0 0 1 1 1 0 C-terminal general transcription factor TFIIE alpha DUF2016 PF09436.10 ELR17383.1 - 0.16 11.8 0.4 0.34 10.7 0.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF2016) RINGv PF12906.7 ELR17384.1 - 6.3e-12 45.4 3.5 1.3e-11 44.4 3.5 1.6 1 0 0 1 1 1 1 RING-variant domain zf-RING_2 PF13639.6 ELR17384.1 - 0.32 11.4 5.4 1.1 9.7 5.2 2.0 1 1 1 2 2 2 0 Ring finger domain PHD PF00628.29 ELR17384.1 - 0.35 10.8 6.7 1.1 9.2 6.1 1.9 1 1 0 1 1 1 0 PHD-finger RPEL PF02755.15 ELR17385.1 - 0.0013 18.3 3.1 0.0013 18.3 3.1 3.5 3 0 0 3 3 3 2 RPEL repeat DUF4834 PF16118.5 ELR17385.1 - 5.5 8.0 10.7 2.5 9.1 2.4 3.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) CLU PF13236.6 ELR17386.1 - 1.3e-50 172.3 0.0 2.2e-50 171.6 0.0 1.4 1 0 0 1 1 1 1 Clustered mitochondria RCC1 PF00415.18 ELR17386.1 - 7.1e-45 151.4 10.6 6.8e-10 39.4 0.0 7.1 7 0 0 7 7 7 6 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 ELR17386.1 - 8.5e-23 79.6 22.7 0.00039 20.1 0.0 6.9 6 0 0 6 6 6 6 Regulator of chromosome condensation (RCC1) repeat eIF3_p135 PF12807.7 ELR17386.1 - 3.6e-06 27.1 1.0 7.7e-06 26.1 1.0 1.5 1 0 0 1 1 1 1 Translation initiation factor eIF3 subunit 135 TPR_12 PF13424.6 ELR17386.1 - 1.7e-05 25.0 0.2 7.3e-05 23.0 0.1 2.2 1 1 1 2 2 2 2 Tetratricopeptide repeat PapC_C PF13953.6 ELR17386.1 - 0.0007 19.4 0.1 0.7 9.7 0.0 3.5 3 0 0 3 3 3 1 PapC C-terminal domain TPR_2 PF07719.17 ELR17386.1 - 0.005 16.8 0.2 0.028 14.5 0.1 2.3 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_1 PF00515.28 ELR17386.1 - 0.0072 16.1 0.1 0.032 14.0 0.0 2.1 2 0 0 2 2 2 1 Tetratricopeptide repeat PaRep2a PF07903.11 ELR17386.1 - 0.012 15.4 0.0 0.028 14.2 0.0 1.6 1 0 0 1 1 1 0 PaRep2a protein TPR_7 PF13176.6 ELR17386.1 - 0.037 14.1 1.1 0.2 11.8 0.2 2.8 3 0 0 3 3 3 0 Tetratricopeptide repeat Paf67 PF10255.9 ELR17386.1 - 0.064 12.2 0.0 0.1 11.6 0.0 1.2 1 0 0 1 1 1 0 RNA polymerase I-associated factor PAF67 HSM3_N PF18795.1 ELR17386.1 - 0.092 12.2 0.0 0.17 11.3 0.0 1.3 1 0 0 1 1 1 0 DNA mismatch repair protein HSM3, N terminal domain TPR_8 PF13181.6 ELR17386.1 - 0.12 12.7 0.0 0.47 10.8 0.0 2.1 1 0 0 1 1 1 0 Tetratricopeptide repeat Rotamase_3 PF13616.6 ELR17387.1 - 1.5e-24 86.8 0.0 2.9e-24 85.8 0.0 1.5 1 1 0 1 1 1 1 PPIC-type PPIASE domain Rotamase PF00639.21 ELR17387.1 - 5.1e-23 81.8 0.0 6.1e-23 81.6 0.0 1.1 1 0 0 1 1 1 1 PPIC-type PPIASE domain Rotamase_2 PF13145.6 ELR17387.1 - 4.3e-09 37.3 0.0 5e-09 37.0 0.0 1.2 1 0 0 1 1 1 1 PPIC-type PPIASE domain IBR PF01485.21 ELR17388.1 - 1.2e-15 57.4 21.7 2.2e-13 50.2 0.9 3.9 4 0 0 4 4 4 2 IBR domain, a half RING-finger domain CDC45 PF02724.14 ELR17388.1 - 0.0063 14.9 6.3 0.0088 14.4 6.3 1.1 1 0 0 1 1 1 1 CDC45-like protein RPN2_C PF18004.1 ELR17388.1 - 0.067 13.1 8.6 0.16 11.8 8.6 1.6 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain RRN3 PF05327.11 ELR17388.1 - 4 5.9 7.3 5.6 5.4 7.3 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Nop14 PF04147.12 ELR17388.1 - 4.2 5.5 19.6 6 4.9 19.6 1.1 1 0 0 1 1 1 0 Nop14-like family zf-RING_2 PF13639.6 ELR17388.1 - 5.7 7.4 40.5 0.36 11.2 11.2 4.0 3 1 0 3 3 3 0 Ring finger domain Cwf_Cwc_15 PF04889.12 ELR17389.1 - 0.36 10.5 2.1 0.44 10.2 2.1 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Ras PF00071.22 ELR17390.1 - 5.2e-27 94.4 0.0 8.1e-27 93.8 0.0 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR17390.1 - 2.4e-12 47.1 0.0 4.7e-12 46.2 0.0 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase F-box-like PF12937.7 ELR17390.1 - 1.9e-09 37.3 0.8 4.2e-09 36.1 0.8 1.6 1 0 0 1 1 1 1 F-box-like DUF1681 PF07933.14 ELR17390.1 - 2e-09 37.3 0.0 3.5e-09 36.5 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1681) F-box PF00646.33 ELR17390.1 - 2.6e-07 30.3 1.7 4.7e-07 29.5 1.7 1.4 1 0 0 1 1 1 1 F-box domain Arf PF00025.21 ELR17390.1 - 0.0031 17.0 0.0 0.005 16.3 0.0 1.4 1 0 0 1 1 1 1 ADP-ribosylation factor family IQ_SEC7_PH PF16453.5 ELR17390.1 - 0.015 15.2 0.1 0.024 14.6 0.1 1.3 1 0 0 1 1 1 0 PH domain Baculo_11_kDa PF06143.11 ELR17390.1 - 0.18 11.4 2.5 0.13 11.8 0.6 1.8 2 0 0 2 2 2 0 Baculovirus 11 kDa family Peptidase_M11 PF05548.11 ELR17391.1 - 0.15 11.2 0.0 0.15 11.2 0.0 1.0 1 0 0 1 1 1 0 Gametolysin peptidase M11 Y_phosphatase3 PF13350.6 ELR17392.1 - 4.4e-38 131.6 0.0 3.7e-37 128.5 0.0 2.4 2 1 0 2 2 2 1 Tyrosine phosphatase family RRM_1 PF00076.22 ELR17392.1 - 2.3e-10 40.1 0.0 0.0016 18.2 0.0 3.2 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Y_phosphatase2 PF03162.13 ELR17392.1 - 2.8e-08 33.5 0.0 1.5e-07 31.2 0.0 2.0 2 0 0 2 2 2 1 Tyrosine phosphatase family Nup35_RRM_2 PF14605.6 ELR17392.1 - 0.00012 22.0 0.1 2.6 8.1 0.0 3.4 3 0 0 3 3 3 1 Nup53/35/40-type RNA recognition motif Y_phosphatase PF00102.27 ELR17392.1 - 0.002 17.7 0.0 0.0035 17.0 0.0 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Myotub-related PF06602.14 ELR17392.1 - 0.099 11.5 0.0 0.17 10.8 0.0 1.3 1 0 0 1 1 1 0 Myotubularin-like phosphatase domain DSPc PF00782.20 ELR17392.1 - 0.13 12.1 0.0 0.32 10.8 0.0 1.5 1 0 0 1 1 1 0 Dual specificity phosphatase, catalytic domain SDA1 PF05285.12 ELR17392.1 - 0.16 11.3 17.1 0.021 14.3 4.6 2.2 2 0 0 2 2 2 0 SDA1 DUF2052 PF09747.9 ELR17392.1 - 0.44 10.7 16.8 0.025 14.7 6.3 2.3 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) Eapp_C PF10238.9 ELR17392.1 - 0.49 10.5 3.6 1.6 8.8 3.6 1.8 1 0 0 1 1 1 0 E2F-associated phosphoprotein EFTUD2 PF16004.5 ELR17392.1 - 1 10.0 14.9 2.7 8.6 0.4 2.5 2 0 0 2 2 2 0 116 kDa U5 small nuclear ribonucleoprotein component N-terminus Connexin PF00029.19 ELR17392.1 - 1.1 9.0 3.2 2.1 8.0 3.2 1.4 1 0 0 1 1 1 0 Connexin Vfa1 PF08432.10 ELR17392.1 - 1.2 9.5 15.3 0.056 13.8 3.4 2.4 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 CENP-B_dimeris PF09026.10 ELR17392.1 - 2.2 8.7 16.6 5.4 7.5 3.7 2.5 2 0 0 2 2 2 0 Centromere protein B dimerisation domain CPSF100_C PF13299.6 ELR17392.1 - 3.8 7.7 11.7 0.76 9.9 4.5 2.4 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal FAM176 PF14851.6 ELR17392.1 - 4 7.1 17.9 1.7 8.3 6.8 2.8 3 0 0 3 3 3 0 FAM176 family DUF3464 PF11947.8 ELR17392.1 - 5.4 6.8 11.0 0.059 13.1 2.0 2.1 2 0 0 2 2 2 0 Photosynthesis affected mutant 68 BSP_II PF05432.11 ELR17392.1 - 6.3 6.4 20.4 0.9 9.2 10.1 2.2 2 0 0 2 2 2 0 Bone sialoprotein II (BSP-II) SpoIIP PF07454.11 ELR17392.1 - 9.8 5.5 9.8 0.11 11.9 1.7 1.8 2 0 0 2 2 2 0 Stage II sporulation protein P (SpoIIP) DUF1674 PF07896.12 ELR17393.1 - 1.1e-16 61.0 5.5 4.2e-16 59.1 5.5 1.9 1 1 0 1 1 1 1 Protein of unknown function (DUF1674) SPICE PF15678.5 ELR17393.1 - 0.046 13.1 0.9 0.053 12.9 0.9 1.0 1 0 0 1 1 1 0 Centriole duplication and mitotic chromosome congression HR1 PF02185.16 ELR17393.1 - 0.048 13.8 0.1 0.06 13.5 0.1 1.2 1 0 0 1 1 1 0 Hr1 repeat FliT PF05400.13 ELR17393.1 - 0.061 14.1 0.1 0.066 14.0 0.1 1.1 1 0 0 1 1 1 0 Flagellar protein FliT DUF3573 PF12097.8 ELR17393.1 - 0.065 12.0 0.0 0.071 11.9 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3573) Dmrt1 PF12374.8 ELR17393.1 - 0.069 13.6 1.6 0.097 13.1 1.6 1.2 1 0 0 1 1 1 0 Double-sex mab3 related transcription factor 1 Beta_helix PF13229.6 ELR17394.1 - 4e-15 56.0 22.8 1.5e-08 34.7 9.5 2.5 2 0 0 2 2 2 2 Right handed beta helix region Pectate_lyase_3 PF12708.7 ELR17394.1 - 0.0078 16.1 2.6 0.0078 16.1 2.6 4.2 3 1 0 3 3 3 1 Pectate lyase superfamily protein Melibiase_2 PF16499.5 ELR17395.1 - 2.6e-76 256.5 1.1 4.6e-76 255.7 1.1 1.4 1 0 0 1 1 1 1 Alpha galactosidase A Melibiase_C PF17801.1 ELR17395.1 - 2e-17 63.0 1.5 5.3e-17 61.7 1.5 1.7 1 0 0 1 1 1 1 Alpha galactosidase C-terminal beta sandwich domain Melibiase PF02065.18 ELR17395.1 - 3.6e-07 29.4 0.2 1.3e-06 27.6 0.0 1.9 2 0 0 2 2 2 1 Melibiase Melibiase_2_C PF17450.2 ELR17395.1 - 0.036 14.3 0.0 0.1 12.9 0.0 1.7 1 1 0 1 1 1 0 Alpha galactosidase A C-terminal beta sandwich domain Methyltransf_16 PF10294.9 ELR17396.1 - 5e-14 52.4 0.1 6e-14 52.2 0.1 1.1 1 0 0 1 1 1 1 Lysine methyltransferase Methyltransf_12 PF08242.12 ELR17396.1 - 0.00044 20.9 0.0 0.00072 20.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ELR17396.1 - 0.016 15.9 0.0 0.025 15.3 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain NodS PF05401.11 ELR17396.1 - 0.039 13.6 0.0 0.053 13.1 0.0 1.2 1 0 0 1 1 1 0 Nodulation protein S (NodS) Acyltransferase PF01553.21 ELR17397.1 - 2.7e-12 46.4 0.0 1.6e-11 44.0 0.0 2.1 1 1 0 1 1 1 1 Acyltransferase C_Hendra PF16821.5 ELR17397.1 - 0.077 12.9 0.4 0.2 11.6 0.2 1.7 2 0 0 2 2 2 0 C protein from hendra and measles viruses TAF4 PF05236.14 ELR17397.1 - 0.27 11.0 5.9 0.43 10.3 5.9 1.2 1 0 0 1 1 1 0 Transcription initiation factor TFIID component TAF4 family Ank_2 PF12796.7 ELR17398.1 - 2e-38 130.9 0.2 6e-07 30.0 0.0 5.8 3 2 2 5 5 5 5 Ankyrin repeats (3 copies) BTB PF00651.31 ELR17398.1 - 4.3e-31 107.4 0.0 5.6e-15 55.5 0.0 3.4 2 1 1 3 3 3 2 BTB/POZ domain Ank_4 PF13637.6 ELR17398.1 - 9.4e-26 89.9 1.8 0.0002 21.9 0.0 7.5 4 3 4 8 8 8 7 Ankyrin repeats (many copies) Ank_5 PF13857.6 ELR17398.1 - 7.5e-24 83.5 2.1 0.001 19.3 0.0 8.4 8 0 0 8 8 8 5 Ankyrin repeats (many copies) Kelch_4 PF13418.6 ELR17398.1 - 8e-23 80.2 8.5 0.00082 19.3 0.0 6.4 5 1 0 5 5 5 5 Galactose oxidase, central domain Ank_3 PF13606.6 ELR17398.1 - 2e-22 76.8 4.5 0.12 13.0 0.0 10.3 10 0 0 10 10 10 6 Ankyrin repeat Kelch_5 PF13854.6 ELR17398.1 - 1.3e-17 63.4 0.3 4.8e-05 23.2 0.0 5.7 5 0 0 5 5 5 3 Kelch motif Kelch_6 PF13964.6 ELR17398.1 - 1.2e-16 60.3 1.9 3e-05 24.1 0.0 5.7 5 1 0 5 5 5 3 Kelch motif Kelch_1 PF01344.25 ELR17398.1 - 5.9e-16 57.8 6.9 3.5e-09 36.1 0.0 5.7 5 1 0 5 5 5 3 Kelch motif Ank PF00023.30 ELR17398.1 - 5e-14 52.0 18.4 0.025 15.0 0.2 8.4 10 0 0 10 10 9 6 Ankyrin repeat Kelch_3 PF13415.6 ELR17398.1 - 4.3e-09 36.4 11.4 0.0014 18.8 0.2 5.9 6 0 0 6 6 6 2 Galactose oxidase, central domain Kelch_2 PF07646.15 ELR17398.1 - 5.3e-08 32.5 7.7 0.033 14.2 0.0 5.7 5 1 0 5 5 5 2 Kelch motif PI3_PI4_kinase PF00454.27 ELR17399.1 - 8.3e-51 173.2 0.0 1.7e-50 172.2 0.0 1.5 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase FAT PF02259.23 ELR17399.1 - 4.9e-17 62.2 5.7 4.9e-17 62.2 5.7 1.8 2 0 0 2 2 2 1 FAT domain FATC PF02260.20 ELR17399.1 - 7.8e-12 44.8 0.1 1.9e-11 43.6 0.1 1.7 1 0 0 1 1 1 1 FATC domain HEAT_2 PF13646.6 ELR17399.1 - 0.00045 20.5 0.1 4.2 7.8 0.0 5.0 4 0 0 4 4 4 1 HEAT repeats CENP-B_dimeris PF09026.10 ELR17399.1 - 0.007 16.7 9.4 0.1 13.0 0.4 2.7 2 0 0 2 2 2 2 Centromere protein B dimerisation domain HEAT PF02985.22 ELR17399.1 - 0.0076 16.4 0.1 5.5 7.5 0.0 4.7 4 0 0 4 4 4 1 HEAT repeat DUF3385 PF11865.8 ELR17399.1 - 0.01 15.7 0.4 1.1 9.1 0.0 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF3385) CLASP_N PF12348.8 ELR17399.1 - 0.072 12.6 0.1 0.27 10.8 0.0 2.0 2 0 0 2 2 2 0 CLASP N terminal Pox_Ag35 PF03286.14 ELR17399.1 - 8.6 6.1 11.9 4.6 7.0 2.0 3.1 3 0 0 3 3 3 0 Pox virus Ag35 surface protein TAN PF11640.8 ELR17400.1 - 2e-06 28.0 2.2 3.1e-06 27.4 1.0 1.9 2 0 0 2 2 2 1 Telomere-length maintenance and DNA damage repair HK PF02110.15 ELR17400.1 - 0.12 11.7 0.1 0.18 11.2 0.1 1.3 1 0 0 1 1 1 0 Hydroxyethylthiazole kinase family EF-hand_7 PF13499.6 ELR17401.1 - 2.5e-30 104.8 11.6 2.3e-10 40.8 0.8 3.5 3 0 0 3 3 3 3 EF-hand domain pair EF-hand_6 PF13405.6 ELR17401.1 - 7.3e-28 94.1 16.5 8.6e-06 25.3 0.1 6.3 6 0 0 6 6 6 5 EF-hand domain EF-hand_1 PF00036.32 ELR17401.1 - 3e-25 85.8 20.7 4.1e-05 22.8 0.1 6.5 6 0 0 6 6 6 5 EF hand EF-hand_5 PF13202.6 ELR17401.1 - 3.5e-13 48.4 17.2 7.2e-05 22.1 0.1 5.7 5 1 0 5 5 5 3 EF hand EF-hand_8 PF13833.6 ELR17401.1 - 5.9e-13 48.5 23.4 2.2e-06 27.4 2.0 6.2 3 3 3 6 6 6 4 EF-hand domain pair EF-hand_9 PF14658.6 ELR17401.1 - 2e-07 31.2 0.1 0.038 14.3 0.0 3.4 3 0 0 3 3 3 2 EF-hand domain SPARC_Ca_bdg PF10591.9 ELR17401.1 - 5.4e-06 26.7 7.2 0.21 11.9 0.3 4.6 4 1 0 4 4 4 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_10 PF14788.6 ELR17401.1 - 0.00016 21.5 9.8 0.3 11.0 0.3 4.7 3 2 2 5 5 5 2 EF hand DUF1456 PF07308.13 ELR17401.1 - 0.0055 17.0 3.4 14 6.1 0.0 4.2 4 1 0 4 4 4 0 Protein of unknown function (DUF1456) EF-hand_11 PF08976.11 ELR17401.1 - 0.0093 16.8 0.2 1 10.2 0.0 2.5 2 0 0 2 2 2 1 EF-hand domain ETF PF01012.21 ELR17401.1 - 0.039 13.9 0.0 0.16 11.9 0.0 1.9 2 0 0 2 2 2 0 Electron transfer flavoprotein domain Beta-lactamase2 PF13354.6 ELR17401.1 - 0.041 13.5 0.1 4.1 6.9 0.1 2.7 2 0 0 2 2 2 0 Beta-lactamase enzyme family Dockerin_1 PF00404.18 ELR17401.1 - 0.043 14.0 1.0 39 4.5 0.1 3.7 3 1 0 4 4 4 0 Dockerin type I domain EF-hand_14 PF17959.1 ELR17401.1 - 0.048 14.0 1.4 13 6.2 0.1 3.7 3 1 1 4 4 4 0 EF-hand domain CCDC106 PF15794.5 ELR17401.1 - 0.049 13.3 0.1 0.075 12.7 0.1 1.3 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 DUF533 PF04391.12 ELR17401.1 - 0.055 13.0 0.2 15 5.1 0.0 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF533) SPOUT_MTase PF02590.17 ELR17401.1 - 0.068 13.1 0.1 0.57 10.2 0.1 2.3 2 0 0 2 2 2 0 Predicted SPOUT methyltransferase Caleosin PF05042.13 ELR17401.1 - 0.08 12.9 5.2 43 4.0 0.2 4.6 3 2 2 5 5 5 0 Caleosin related protein Retrotrans_gag PF03732.17 ELR17401.1 - 0.082 13.2 1.4 0.86 9.9 0.1 2.8 3 0 0 3 3 3 0 Retrotransposon gag protein EF-hand_like PF09279.11 ELR17401.1 - 0.42 11.1 3.4 9.9 6.7 0.1 3.5 3 2 0 3 3 3 0 Phosphoinositide-specific phospholipase C, efhand-like SurA_N_2 PF13623.6 ELR17401.1 - 1.1 9.1 4.7 7.3 6.4 0.1 3.5 3 1 1 4 4 4 0 SurA N-terminal domain RhoGEF PF00621.20 ELR17402.1 - 6.7e-30 104.7 0.0 1.2e-29 103.8 0.0 1.5 1 0 0 1 1 1 1 RhoGEF domain Kelch_6 PF13964.6 ELR17402.1 - 1.4e-21 75.9 1.2 1.4e-06 28.4 0.0 5.8 4 1 1 5 5 5 4 Kelch motif Kelch_4 PF13418.6 ELR17402.1 - 3.9e-20 71.6 4.9 4.1e-05 23.5 0.0 5.9 4 1 1 5 5 5 3 Galactose oxidase, central domain Kelch_1 PF01344.25 ELR17402.1 - 4.3e-20 71.0 1.2 1.1e-05 25.0 0.0 5.7 5 0 0 5 5 5 3 Kelch motif Kelch_3 PF13415.6 ELR17402.1 - 2.2e-18 66.1 7.4 2.8e-05 24.3 0.0 6.1 5 0 0 5 5 5 3 Galactose oxidase, central domain Kelch_2 PF07646.15 ELR17402.1 - 6e-16 57.7 5.8 0.00013 21.8 0.0 6.1 5 0 0 5 5 5 3 Kelch motif Kelch_5 PF13854.6 ELR17402.1 - 7.1e-16 57.8 0.6 0.027 14.5 0.1 6.0 5 0 0 5 5 5 5 Kelch motif Amino_oxidase PF01593.24 ELR17402.1 - 5.7e-14 52.3 0.2 1.9e-13 50.5 0.2 1.9 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 ELR17402.1 - 6e-11 42.4 0.1 1.8e-10 40.9 0.1 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 ELR17402.1 - 5e-08 32.9 5.0 8e-07 29.0 5.0 2.4 1 1 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 ELR17402.1 - 2.2e-07 30.4 2.9 0.00031 20.1 0.6 2.7 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 ELR17402.1 - 8e-06 26.3 2.6 0.0098 16.4 1.3 2.6 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 ELR17402.1 - 1.3e-05 24.7 0.0 2.8e-05 23.7 0.0 1.5 1 0 0 1 1 1 1 FAD dependent oxidoreductase Thi4 PF01946.17 ELR17402.1 - 0.00011 21.6 0.4 0.00011 21.6 0.4 1.8 2 0 0 2 2 2 1 Thi4 family HI0933_like PF03486.14 ELR17402.1 - 0.00044 19.1 1.8 0.012 14.4 0.9 2.3 2 0 0 2 2 2 1 HI0933-like protein FAD_binding_2 PF00890.24 ELR17402.1 - 0.00045 19.4 4.9 0.00045 19.4 4.9 2.6 3 0 0 3 3 3 1 FAD binding domain IQ_SEC7_PH PF16453.5 ELR17402.1 - 0.00057 19.9 0.0 0.0012 18.8 0.0 1.5 1 0 0 1 1 1 1 PH domain FAD_binding_3 PF01494.19 ELR17402.1 - 0.00083 18.7 0.3 0.0022 17.3 0.3 1.7 1 0 0 1 1 1 1 FAD binding domain Trp_halogenase PF04820.14 ELR17402.1 - 0.011 14.6 1.0 0.35 9.6 0.2 2.4 2 0 0 2 2 2 0 Tryptophan halogenase PH PF00169.29 ELR17402.1 - 0.011 16.2 0.0 0.033 14.7 0.0 1.9 1 0 0 1 1 1 0 PH domain PH_10 PF15411.6 ELR17402.1 - 0.063 13.5 0.0 0.14 12.4 0.0 1.6 1 0 0 1 1 1 0 Pleckstrin homology domain GIDA PF01134.22 ELR17402.1 - 0.11 11.6 4.9 0.14 11.2 2.9 2.0 2 0 0 2 2 2 0 Glucose inhibited division protein A Erf4 PF10256.9 ELR17403.1 - 0.03 14.4 0.2 0.066 13.3 0.2 1.6 1 1 0 1 1 1 0 Golgin subfamily A member 7/ERF4 family Ycf9 PF01737.17 ELR17403.1 - 0.15 12.0 0.1 0.43 10.5 0.1 1.7 2 0 0 2 2 2 0 YCF9 Tex_YqgF PF16921.5 ELR17404.1 - 2.5e-44 150.8 0.0 6e-44 149.5 0.0 1.7 1 0 0 1 1 1 1 Tex protein YqgF-like domain Tex_N PF09371.10 ELR17404.1 - 3e-39 134.6 1.7 1e-38 132.8 1.7 1.9 1 0 0 1 1 1 1 Tex-like protein N-terminal domain HHH_3 PF12836.7 ELR17404.1 - 2.8e-23 81.9 0.1 7.3e-23 80.6 0.1 1.8 1 0 0 1 1 1 1 Helix-hairpin-helix motif S1 PF00575.23 ELR17404.1 - 1.2e-13 51.2 1.1 1e-12 48.2 0.1 2.5 2 0 0 2 2 2 1 S1 RNA binding domain HHH_9 PF17674.1 ELR17404.1 - 1.4e-12 48.3 3.4 1.9e-12 47.9 0.1 3.2 3 1 0 3 3 3 1 HHH domain HHH_7 PF14635.6 ELR17404.1 - 3e-07 30.7 0.0 6.4e-07 29.7 0.0 1.5 1 0 0 1 1 1 1 Helix-hairpin-helix motif YqgF PF14639.6 ELR17404.1 - 2.1e-06 27.6 0.0 5.7e-06 26.2 0.0 1.8 1 0 0 1 1 1 1 Holliday-junction resolvase-like of SPT6 HHH PF00633.23 ELR17404.1 - 0.065 13.1 0.0 1.2 9.1 0.0 2.9 3 0 0 3 3 3 0 Helix-hairpin-helix motif LRR_4 PF12799.7 ELR17406.1 - 5.2e-05 23.5 16.5 0.9 10.0 0.1 6.9 6 2 2 8 8 8 4 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 ELR17406.1 - 4.5 8.2 0.0 4.5 8.2 0.0 8.0 9 2 0 9 9 9 0 Leucine Rich Repeat LRR_6 PF13516.6 ELR17406.1 - 6.4 7.1 20.5 6.1 7.2 0.2 9.1 13 0 0 13 13 13 0 Leucine Rich repeat F_actin_bund_C PF18060.1 ELR17407.1 - 2.9e-16 59.4 16.4 2.9e-16 59.4 16.4 5.0 2 1 1 4 4 4 1 F actin bundling C terminal RFX_DNA_binding PF02257.15 ELR17408.1 - 3.2e-22 78.9 0.2 6.5e-22 77.9 0.2 1.5 1 0 0 1 1 1 1 RFX DNA-binding domain PAS_11 PF14598.6 ELR17408.1 - 0.25 11.5 1.6 1.5 8.9 0.4 2.3 2 0 0 2 2 2 0 PAS domain FHA PF00498.26 ELR17409.1 - 1.1e-06 28.9 0.2 2e-06 28.0 0.2 1.4 1 0 0 1 1 1 1 FHA domain Pes-10 PF07149.11 ELR17409.1 - 7.6 5.5 6.2 11 5.0 6.2 1.1 1 0 0 1 1 1 0 Pes-10 5_nucleotid_C PF02872.18 ELR17410.1 - 5.3e-27 95.0 0.2 9.8e-27 94.1 0.2 1.4 1 0 0 1 1 1 1 5'-nucleotidase, C-terminal domain RasGAP PF00616.19 ELR17410.1 - 5e-22 78.6 0.1 1.1e-21 77.6 0.1 1.6 1 0 0 1 1 1 1 GTPase-activator protein for Ras-like GTPase SKG6 PF08693.10 ELR17410.1 - 0.00073 18.9 0.6 0.00073 18.9 0.6 2.0 2 0 0 2 2 1 1 Transmembrane alpha-helix domain EGF_2 PF07974.13 ELR17410.1 - 0.0012 19.2 8.8 0.0025 18.1 8.8 1.6 1 0 0 1 1 1 1 EGF-like domain I-EGF_1 PF18372.1 ELR17410.1 - 0.019 15.0 5.3 0.038 14.1 5.3 1.5 1 0 0 1 1 1 0 Integrin beta epidermal growth factor like domain 1 EGF_Tenascin PF18720.1 ELR17410.1 - 0.062 13.4 5.7 0.13 12.4 5.7 1.5 1 0 0 1 1 1 0 Tenascin EGF domain DUF3377 PF11857.8 ELR17410.1 - 0.076 12.9 0.1 0.076 12.9 0.1 1.9 2 0 0 2 2 1 0 Domain of unknown function (DUF3377) EB PF01683.18 ELR17410.1 - 0.077 13.3 1.8 0.16 12.3 1.8 1.4 1 0 0 1 1 1 0 EB module Laminin_EGF PF00053.24 ELR17410.1 - 0.11 12.7 5.6 0.24 11.6 5.6 1.5 1 0 0 1 1 1 0 Laminin EGF domain hEGF PF12661.7 ELR17410.1 - 0.65 10.7 7.3 1.6 9.5 7.3 1.7 1 0 0 1 1 1 0 Human growth factor-like EGF EGF PF00008.27 ELR17410.1 - 0.73 10.2 5.0 1.4 9.3 5.0 1.5 1 0 0 1 1 1 0 EGF-like domain 5_nucleotid_C PF02872.18 ELR17411.1 - 2e-30 106.1 0.0 3.4e-30 105.3 0.0 1.4 1 0 0 1 1 1 1 5'-nucleotidase, C-terminal domain RasGAP PF00616.19 ELR17411.1 - 6e-23 81.6 0.0 1.3e-22 80.5 0.0 1.6 1 0 0 1 1 1 1 GTPase-activator protein for Ras-like GTPase SKG6 PF08693.10 ELR17411.1 - 0.037 13.4 0.5 0.12 11.8 0.5 2.0 1 0 0 1 1 1 0 Transmembrane alpha-helix domain EGF_2 PF07974.13 ELR17411.1 - 0.076 13.4 7.7 0.14 12.6 7.7 1.5 1 0 0 1 1 1 0 EGF-like domain CBM_X2 PF03442.14 ELR17411.1 - 0.15 12.2 0.0 0.39 10.9 0.0 1.7 1 0 0 1 1 1 0 Carbohydrate binding domain X2 I-EGF_1 PF18372.1 ELR17411.1 - 0.84 9.8 4.0 1.7 8.8 4.0 1.5 1 0 0 1 1 1 0 Integrin beta epidermal growth factor like domain 1 LSM PF01423.22 ELR17412.1 - 2.5e-16 59.1 0.7 3e-16 58.8 0.7 1.1 1 0 0 1 1 1 1 LSM domain Hfq PF17209.3 ELR17412.1 - 0.0032 17.1 0.1 0.0069 16.0 0.0 1.5 2 0 0 2 2 2 1 Hfq protein Ribosomal_L16 PF00252.18 ELR17413.1 - 2.3e-42 144.1 0.2 3e-42 143.8 0.2 1.1 1 0 0 1 1 1 1 Ribosomal protein L16p/L10e Malate_DH PF12434.8 ELR17413.1 - 0.19 11.8 0.0 0.4 10.8 0.0 1.5 1 0 0 1 1 1 0 Malate dehydrogenase enzyme WD40 PF00400.32 ELR17414.1 - 8.6e-21 73.9 6.6 0.0031 18.3 0.0 9.9 10 0 0 10 10 10 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ELR17414.1 - 1.4e-11 44.5 0.0 0.0026 18.0 0.0 6.1 6 3 1 7 7 7 3 Anaphase-promoting complex subunit 4 WD40 domain P-mevalo_kinase PF04275.14 ELR17415.1 - 1.1e-11 44.6 0.5 3.1e-11 43.2 0.5 1.7 1 1 0 1 1 1 1 Phosphomevalonate kinase PH PF00169.29 ELR17416.1 - 9.5e-05 22.9 0.2 0.02 15.4 0.2 2.7 1 1 0 1 1 1 1 PH domain VIR_N PF15912.5 ELR17416.1 - 4.5 6.8 15.0 6.5 6.3 15.0 1.2 1 0 0 1 1 1 0 Virilizer, N-terminal DUF45 PF01863.17 ELR17417.1 - 1.7 8.6 4.2 33 4.4 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function DUF45 bZIP_1 PF00170.21 ELR17418.1 - 2.2e-10 40.5 8.2 6.4e-10 39.0 8.2 1.8 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 ELR17418.1 - 5e-06 26.5 7.8 5e-06 26.5 7.8 2.6 2 0 0 2 2 2 1 Basic region leucine zipper bZIP_Maf PF03131.17 ELR17418.1 - 0.0018 18.8 8.0 0.0018 18.8 8.0 2.1 2 0 0 2 2 2 1 bZIP Maf transcription factor TSC22 PF01166.18 ELR17418.1 - 0.32 11.3 2.6 0.39 11.1 1.2 1.9 1 1 0 1 1 1 0 TSC-22/dip/bun family GAS PF13851.6 ELR17418.1 - 0.78 9.0 15.7 1.6 8.0 14.6 2.0 1 1 0 1 1 1 0 Growth-arrest specific micro-tubule binding DUF3827 PF12877.7 ELR17418.1 - 6.8 4.9 16.4 0.67 8.3 9.6 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF3827) Macoilin PF09726.9 ELR17418.1 - 7.2 5.0 11.9 9.9 4.6 11.9 1.1 1 0 0 1 1 1 0 Macoilin family Actin PF00022.19 ELR17419.1 - 2.2e-86 290.0 0.0 2.7e-85 286.4 0.0 1.9 1 1 0 1 1 1 1 Actin Pkinase PF00069.25 ELR17420.1 - 1.5e-46 158.9 0.0 6e-46 156.9 0.0 2.0 2 1 0 2 2 2 1 Protein kinase domain EDR1 PF14381.6 ELR17420.1 - 1.7e-39 135.6 0.0 2.7e-39 135.0 0.0 1.3 1 0 0 1 1 1 1 Ethylene-responsive protein kinase Le-CTR1 Pkinase_Tyr PF07714.17 ELR17420.1 - 3.1e-38 131.5 0.0 1.3e-37 129.5 0.0 1.9 1 1 0 1 1 1 1 Protein tyrosine kinase Ank_2 PF12796.7 ELR17420.1 - 2.1e-15 57.1 0.0 1.3e-14 54.5 0.0 2.2 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 ELR17420.1 - 3.3e-15 55.9 2.2 1e-08 35.2 0.3 2.6 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 ELR17420.1 - 3.3e-14 52.6 0.7 1.7e-05 25.0 0.1 3.1 2 0 0 2 2 2 2 Ankyrin repeat Ank_4 PF13637.6 ELR17420.1 - 2.4e-12 47.1 0.5 4.9e-07 30.2 0.1 2.7 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 ELR17420.1 - 2.9e-09 36.4 0.1 0.0061 17.0 0.0 3.0 2 0 0 2 2 2 2 Ankyrin repeat EcKinase PF02958.20 ELR17420.1 - 0.00021 20.7 0.0 0.13 11.5 0.0 2.3 2 0 0 2 2 2 2 Ecdysteroid kinase Pkinase_fungal PF17667.1 ELR17420.1 - 0.0039 16.0 0.0 0.0068 15.2 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase DUF1679 PF07914.11 ELR17420.1 - 0.008 15.1 0.0 0.013 14.4 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1679) Transglut_core PF01841.19 ELR17420.1 - 0.11 13.0 0.1 0.25 11.8 0.1 1.5 1 0 0 1 1 1 0 Transglutaminase-like superfamily DUF3384 PF11864.8 ELR17421.1 - 5e-54 184.0 1.1 7.8e-51 173.5 0.9 2.9 1 1 1 2 2 2 2 Domain of unknown function (DUF3384) Rap_GAP PF02145.15 ELR17421.1 - 1.3e-49 168.2 0.1 2.4e-49 167.4 0.1 1.4 1 0 0 1 1 1 1 Rap/ran-GAP Tuberin PF03542.16 ELR17421.1 - 3e-18 66.1 0.1 2.3e-15 56.6 0.0 2.5 2 0 0 2 2 2 2 Tuberin DUF4800 PF16057.5 ELR17421.1 - 0.038 13.2 0.0 0.07 12.4 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4800) DCB PF16213.5 ELR17421.1 - 0.17 11.6 0.4 0.68 9.6 0.1 2.0 2 0 0 2 2 2 0 Dimerisation and cyclophilin-binding domain of Mon2 Str_synth PF03088.16 ELR17422.1 - 7.3e-20 70.9 0.0 7.7e-18 64.4 0.0 3.2 3 1 0 3 3 3 1 Strictosidine synthase SGL PF08450.12 ELR17422.1 - 7.1e-09 35.6 0.0 3.5e-08 33.3 0.0 2.2 2 1 0 2 2 2 1 SMP-30/Gluconolactonase/LRE-like region PQQ_3 PF13570.6 ELR17422.1 - 0.00089 19.7 1.3 0.022 15.3 0.2 3.0 3 0 0 3 3 3 1 PQQ-like domain PQQ PF01011.21 ELR17422.1 - 0.071 13.1 0.1 0.5 10.4 0.1 2.4 2 0 0 2 2 2 0 PQQ enzyme repeat NHL PF01436.21 ELR17422.1 - 0.19 11.9 0.1 8.9 6.6 0.0 3.6 5 0 0 5 5 5 0 NHL repeat PetM PF08041.11 ELR17422.1 - 0.23 11.1 0.8 0.48 10.0 0.8 1.5 1 0 0 1 1 1 0 PetM family of cytochrome b6f complex subunit 7 PARG_cat PF05028.14 ELR17423.1 - 1e-121 406.4 0.0 1.5e-121 405.9 0.0 1.2 1 0 0 1 1 1 1 Poly (ADP-ribose) glycohydrolase (PARG) zf-CCHH PF10283.9 ELR17423.1 - 3.3e-09 36.6 0.6 6e-09 35.7 0.6 1.4 1 0 0 1 1 1 1 PBZ domain LIM PF00412.22 ELR17424.1 - 3e-37 126.6 30.7 2e-12 47.1 1.1 3.4 3 0 0 3 3 3 3 LIM domain CH PF00307.31 ELR17424.1 - 6.5e-11 42.4 0.1 1.2e-10 41.6 0.1 1.5 1 0 0 1 1 1 1 Calponin homology (CH) domain Aconitase PF00330.20 ELR17425.1 - 5.3e-87 292.7 0.5 1.9e-42 145.8 0.1 4.0 1 1 2 3 3 3 3 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 ELR17425.1 - 3.3e-23 82.4 0.0 6e-23 81.6 0.0 1.4 1 0 0 1 1 1 1 Aconitase C-terminal domain Ribosomal_L5_C PF00673.21 ELR17426.1 - 8.8e-21 73.9 0.0 1.3e-20 73.4 0.0 1.3 1 0 0 1 1 1 1 ribosomal L5P family C-terminus Ribosomal_L5 PF00281.19 ELR17426.1 - 2.7e-18 66.1 0.5 7.9e-18 64.5 0.0 1.9 2 0 0 2 2 2 1 Ribosomal protein L5 HTH_ABP1_N PF18107.1 ELR17426.1 - 0.18 11.5 0.3 0.37 10.5 0.0 1.6 2 0 0 2 2 2 0 Fission yeast centromere protein N-terminal domain Patched PF02460.18 ELR17427.1 - 5.1e-29 100.9 14.4 8.4e-29 100.2 14.4 1.2 1 0 0 1 1 1 1 Patched family RhoGEF PF00621.20 ELR17428.1 - 1.8e-16 60.9 1.9 5.5e-12 46.3 0.9 2.4 1 1 1 2 2 2 2 RhoGEF domain PH PF00169.29 ELR17428.1 - 1.2e-15 57.9 3.4 2.2e-09 37.7 0.2 3.5 2 1 1 3 3 3 2 PH domain PH_11 PF15413.6 ELR17428.1 - 1.5e-06 28.5 0.0 5.6e-05 23.5 0.0 2.8 2 0 0 2 2 2 1 Pleckstrin homology domain Vps62 PF06101.11 ELR17428.1 - 5.7e-06 24.9 0.0 1.4e-05 23.6 0.0 1.6 2 0 0 2 2 2 1 Vacuolar protein sorting-associated protein 62 zf-RanBP PF00641.18 ELR17428.1 - 0.0003 20.0 2.3 0.00055 19.2 2.3 1.4 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others RNase_PH PF01138.21 ELR17429.1 - 8.3e-15 55.5 1.7 4.2e-14 53.2 1.7 2.0 1 1 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 ELR17429.1 - 0.00031 20.7 0.0 0.0007 19.6 0.0 1.6 1 0 0 1 1 1 1 3' exoribonuclease family, domain 2 TauE PF01925.19 ELR17430.1 - 1.4e-17 64.1 44.3 1.6e-15 57.4 20.7 2.0 1 1 1 2 2 2 2 Sulfite exporter TauE/SafE DUF1295 PF06966.12 ELR17431.1 - 4.7e-53 180.1 5.7 1e-27 97.2 0.4 2.2 1 1 1 2 2 2 2 Protein of unknown function (DUF1295) ICMT PF04140.14 ELR17431.1 - 0.0023 18.3 0.1 0.0054 17.1 0.1 1.7 1 0 0 1 1 1 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family PEMT PF04191.13 ELR17431.1 - 0.0041 17.5 0.2 0.013 15.8 0.2 1.9 1 0 0 1 1 1 1 Phospholipid methyltransferase Steroid_dh PF02544.16 ELR17431.1 - 0.023 14.7 0.4 0.063 13.3 0.4 1.7 1 0 0 1 1 1 0 3-oxo-5-alpha-steroid 4-dehydrogenase Ank_2 PF12796.7 ELR17433.1 - 2.9e-101 332.2 34.0 2.3e-19 69.7 0.4 8.5 4 2 5 9 9 9 9 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ELR17433.1 - 2.4e-87 286.3 10.5 1.4e-11 44.7 0.5 12.5 3 3 9 13 13 13 13 Ankyrin repeats (many copies) Ank_5 PF13857.6 ELR17433.1 - 9.7e-76 248.8 18.3 5.6e-10 39.3 0.1 12.1 6 3 7 13 13 13 12 Ankyrin repeats (many copies) Ank PF00023.30 ELR17433.1 - 1.4e-69 227.7 27.0 7.9e-06 26.1 0.1 15.9 16 0 0 16 16 16 13 Ankyrin repeat Sec7 PF01369.20 ELR17433.1 - 4.6e-58 195.9 2.2 6.9e-58 195.4 2.2 1.3 1 0 0 1 1 1 1 Sec7 domain Ank_3 PF13606.6 ELR17433.1 - 1.9e-56 181.4 19.9 0.00011 22.3 0.0 16.1 17 0 0 17 17 17 12 Ankyrin repeat PH PF00169.29 ELR17433.1 - 9.9e-23 80.7 0.8 2.2e-22 79.5 0.8 1.7 1 0 0 1 1 1 1 PH domain PH_11 PF15413.6 ELR17433.1 - 2.2e-05 24.8 0.2 5.6e-05 23.5 0.2 1.8 1 0 0 1 1 1 1 Pleckstrin homology domain Ribosomal_S26e PF01283.19 ELR17434.1 - 2.7e-49 166.1 9.5 3.3e-49 165.8 9.5 1.1 1 0 0 1 1 1 1 Ribosomal protein S26e Peptidase_S28 PF05577.12 ELR17435.1 - 1.4e-125 419.5 0.0 1.7e-125 419.2 0.0 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase S28 Abhydrolase_1 PF00561.20 ELR17435.1 - 0.008 15.8 0.0 0.043 13.4 0.0 1.9 1 1 1 2 2 2 1 alpha/beta hydrolase fold Peptidase_S37 PF05576.11 ELR17435.1 - 0.032 12.9 0.0 0.046 12.4 0.0 1.2 1 0 0 1 1 1 0 PS-10 peptidase S37 RabGAP-TBC PF00566.18 ELR17436.1 - 1.7e-52 178.2 0.5 2.7e-52 177.6 0.5 1.3 1 0 0 1 1 1 1 Rab-GTPase-TBC domain Pkinase PF00069.25 ELR17437.1 - 1.2e-61 208.4 0.0 3e-61 207.1 0.0 1.7 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR17437.1 - 4.8e-25 88.3 0.6 4.7e-23 81.8 0.6 2.2 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ELR17437.1 - 1.2e-07 31.4 0.1 7.1e-07 28.8 0.1 2.1 1 1 0 1 1 1 1 Kinase-like APH PF01636.23 ELR17437.1 - 5.5e-07 29.8 0.0 0.0027 17.7 0.2 2.5 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.14 ELR17437.1 - 1.3e-05 24.6 0.1 3.2e-05 23.4 0.1 1.6 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 ELR17437.1 - 0.00065 18.8 0.0 0.0012 17.9 0.0 1.4 1 0 0 1 1 1 1 Haspin like kinase domain RIO1 PF01163.22 ELR17437.1 - 0.0069 16.0 0.0 0.0069 16.0 0.0 2.1 2 0 0 2 2 2 1 RIO1 family TMEM154 PF15102.6 ELR17437.1 - 0.035 14.0 0.5 0.079 12.9 0.0 1.8 2 0 0 2 2 2 0 TMEM154 protein family Pkinase_fungal PF17667.1 ELR17437.1 - 0.04 12.7 1.1 0.051 12.3 0.0 1.6 2 0 0 2 2 2 0 Fungal protein kinase Choline_kinase PF01633.20 ELR17437.1 - 0.09 12.4 0.0 0.21 11.2 0.0 1.6 1 0 0 1 1 1 0 Choline/ethanolamine kinase DUF3945 PF13101.6 ELR17437.1 - 0.13 12.0 0.8 0.66 9.7 0.2 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3945) V_ATPase_I PF01496.19 ELR17437.1 - 0.15 9.9 0.0 0.28 9.0 0.0 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family FHIPEP PF00771.20 ELR17437.1 - 0.19 10.1 0.0 0.29 9.5 0.0 1.2 1 0 0 1 1 1 0 FHIPEP family Seadorna_VP7 PF07387.11 ELR17437.1 - 0.21 10.6 0.0 0.35 9.9 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 Connexin PF00029.19 ELR17437.1 - 0.28 10.9 0.0 0.28 10.9 0.0 1.7 2 0 0 2 2 1 0 Connexin FAM176 PF14851.6 ELR17437.1 - 0.71 9.5 3.8 0.62 9.7 0.1 2.2 2 0 0 2 2 2 0 FAM176 family TRAP_alpha PF03896.16 ELR17437.1 - 1.6 7.9 4.7 0.64 9.2 0.2 2.1 2 0 0 2 2 2 0 Translocon-associated protein (TRAP), alpha subunit YqfQ PF14181.6 ELR17437.1 - 3 8.0 10.2 0.061 13.5 2.2 2.0 2 0 0 2 2 2 0 YqfQ-like protein HK PF02110.15 ELR17438.1 - 1.9e-58 197.8 0.8 1.9e-58 197.8 0.8 2.6 1 1 1 2 2 2 1 Hydroxyethylthiazole kinase family TMP-TENI PF02581.17 ELR17438.1 - 2.7e-49 166.9 4.0 5.2e-49 166.0 4.0 1.5 1 0 0 1 1 1 1 Thiamine monophosphate synthase DUF561 PF04481.12 ELR17438.1 - 0.00078 18.7 0.7 0.0021 17.3 0.2 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF561) SOR_SNZ PF01680.17 ELR17438.1 - 0.0024 17.7 1.4 0.0071 16.2 0.2 2.1 2 0 0 2 2 2 1 SOR/SNZ family His_biosynth PF00977.21 ELR17438.1 - 0.055 12.9 0.4 0.12 11.8 0.4 1.5 1 0 0 1 1 1 0 Histidine biosynthesis protein Dus PF01207.17 ELR17438.1 - 0.077 12.1 0.2 0.15 11.1 0.2 1.6 1 0 0 1 1 1 0 Dihydrouridine synthase (Dus) AWPM-19 PF05512.11 ELR17438.1 - 0.62 10.3 5.9 7.5 6.7 0.2 2.6 2 0 0 2 2 2 0 AWPM-19-like family Phos_pyr_kin PF08543.12 ELR17439.1 - 6.4e-74 248.4 0.9 7.9e-71 238.3 0.9 2.2 1 1 0 1 1 1 1 Phosphomethylpyrimidine kinase TENA_THI-4 PF03070.16 ELR17439.1 - 6.2e-44 150.3 0.0 1.3e-43 149.3 0.0 1.5 1 1 0 1 1 1 1 TENA/THI-4/PQQC family PfkB PF00294.24 ELR17439.1 - 0.00033 20.0 0.6 0.045 13.1 0.1 2.2 2 0 0 2 2 2 2 pfkB family carbohydrate kinase GCK PF07802.11 ELR17439.1 - 0.054 13.9 0.1 0.12 12.8 0.1 1.6 1 0 0 1 1 1 0 GCK domain ERAP1_C PF11838.8 ELR17440.1 - 3.1e-71 240.5 0.7 5.2e-71 239.8 0.7 1.4 1 0 0 1 1 1 1 ERAP1-like C-terminal domain Peptidase_M1 PF01433.20 ELR17440.1 - 1.7e-69 233.7 4.6 2.1e-47 161.5 3.1 2.2 2 0 0 2 2 2 2 Peptidase family M1 domain Peptidase_M1_N PF17900.1 ELR17440.1 - 3e-30 105.8 0.0 6.9e-30 104.6 0.0 1.5 2 0 0 2 2 2 1 Peptidase M1 N-terminal domain RSN1_7TM PF02714.15 ELR17441.1 - 1.7e-56 191.6 28.8 1.7e-56 191.6 28.8 1.9 2 0 0 2 2 2 1 Calcium-dependent channel, 7TM region, putative phosphate RSN1_TM PF13967.6 ELR17441.1 - 4.6e-20 72.0 2.9 4.6e-20 72.0 2.9 2.9 3 0 0 3 3 3 1 Late exocytosis, associated with Golgi transport PHM7_cyt PF14703.6 ELR17441.1 - 9.3e-19 68.3 2.4 2.5e-09 37.6 0.3 2.3 2 0 0 2 2 2 2 Cytosolic domain of 10TM putative phosphate transporter TMEM171 PF15471.6 ELR17441.1 - 0.26 10.2 0.4 0.9 8.5 0.1 1.9 2 0 0 2 2 2 0 Transmembrane protein family 171 Presenilin PF01080.17 ELR17442.1 - 0.018 13.8 0.7 0.027 13.3 0.7 1.1 1 0 0 1 1 1 0 Presenilin Pox_Ag35 PF03286.14 ELR17442.1 - 0.89 9.3 7.3 1.5 8.6 7.3 1.3 1 0 0 1 1 1 0 Pox virus Ag35 surface protein Ank_2 PF12796.7 ELR17443.1 - 1.7e-20 73.4 1.0 1e-05 26.0 0.0 4.6 3 1 1 4 4 4 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ELR17443.1 - 8.4e-14 51.8 3.7 0.022 15.3 0.0 6.0 5 1 1 6 6 6 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 ELR17443.1 - 6.3e-11 41.5 7.8 0.05 14.2 0.0 7.8 8 0 0 8 8 8 3 Ankyrin repeat Ank PF00023.30 ELR17443.1 - 4.8e-09 36.3 12.3 0.026 15.0 0.0 6.5 8 0 0 8 8 8 3 Ankyrin repeat Ank_5 PF13857.6 ELR17443.1 - 2e-08 34.3 15.1 0.048 14.0 0.0 7.1 5 3 2 7 7 7 3 Ankyrin repeats (many copies) ATP_transf PF09830.9 ELR17444.1 - 7.6e-14 51.6 0.0 1.4e-13 50.8 0.0 1.5 1 0 0 1 1 1 1 ATP adenylyltransferase SKI PF01202.22 ELR17445.1 - 1.3e-07 31.9 0.0 2.8e-07 30.8 0.0 1.5 1 1 0 1 1 1 1 Shikimate kinase AAA_16 PF13191.6 ELR17445.1 - 0.00011 22.7 0.0 0.00015 22.2 0.0 1.4 1 1 0 1 1 1 1 AAA ATPase domain CPT PF07931.12 ELR17445.1 - 0.00038 20.4 0.0 0.00063 19.6 0.0 1.3 1 0 0 1 1 1 1 Chloramphenicol phosphotransferase-like protein AAA_33 PF13671.6 ELR17445.1 - 0.0014 18.8 0.0 0.004 17.3 0.0 1.8 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.6 ELR17445.1 - 0.0058 17.2 0.0 0.015 15.9 0.0 1.8 1 1 0 1 1 1 1 AAA domain AAA_14 PF13173.6 ELR17445.1 - 0.012 15.6 0.0 0.019 15.0 0.0 1.3 1 1 0 1 1 1 0 AAA domain AAA PF00004.29 ELR17445.1 - 0.014 15.9 0.3 0.2 12.1 0.1 2.5 2 1 1 3 3 3 0 ATPase family associated with various cellular activities (AAA) ABC_tran PF00005.27 ELR17445.1 - 0.028 14.9 0.0 0.18 12.3 0.0 2.1 2 0 0 2 2 2 0 ABC transporter AAA_22 PF13401.6 ELR17445.1 - 0.043 14.1 0.1 0.077 13.3 0.1 1.8 1 1 1 2 2 2 0 AAA domain Zeta_toxin PF06414.12 ELR17445.1 - 0.078 12.2 0.0 0.15 11.3 0.0 1.5 2 0 0 2 2 2 0 Zeta toxin NACHT PF05729.12 ELR17445.1 - 0.089 12.7 0.2 0.49 10.3 0.0 2.1 2 1 1 3 3 3 0 NACHT domain RNA_helicase PF00910.22 ELR17445.1 - 0.13 12.7 0.0 1.2 9.6 0.0 2.2 2 1 0 2 2 2 0 RNA helicase SMC_N PF02463.19 ELR17445.1 - 0.14 11.5 0.0 0.33 10.4 0.0 1.5 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain PRK PF00485.18 ELR17445.1 - 0.16 11.7 0.0 0.22 11.3 0.0 1.3 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family tRNA_lig_kinase PF08303.11 ELR17445.1 - 0.18 11.9 0.0 0.42 10.7 0.0 1.6 2 0 0 2 2 2 0 tRNA ligase kinase domain ADK PF00406.22 ELR17446.1 - 6e-50 169.3 0.0 7e-50 169.0 0.0 1.0 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 ELR17446.1 - 1.4e-36 125.9 0.0 1.7e-36 125.6 0.0 1.1 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 ELR17446.1 - 1e-13 51.9 0.0 1.4e-13 51.6 0.0 1.1 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 ELR17446.1 - 3.6e-08 33.7 0.0 5.2e-08 33.2 0.0 1.2 1 0 0 1 1 1 1 AAA domain Zeta_toxin PF06414.12 ELR17446.1 - 3.8e-05 23.1 0.0 5.1e-05 22.6 0.0 1.2 1 0 0 1 1 1 1 Zeta toxin Thymidylate_kin PF02223.17 ELR17446.1 - 0.00012 21.9 0.5 0.38 10.4 0.0 2.1 1 1 1 2 2 2 2 Thymidylate kinase AAA_19 PF13245.6 ELR17446.1 - 0.091 13.1 0.1 0.21 11.9 0.1 1.6 1 0 0 1 1 1 0 AAA domain Ploopntkinase3 PF18751.1 ELR17446.1 - 0.11 12.4 0.0 0.18 11.7 0.0 1.4 1 0 0 1 1 1 0 P-loop Nucleotide Kinase3 DHO_dh PF01180.21 ELR17447.1 - 1.2e-95 320.1 0.0 1.4e-95 319.9 0.0 1.0 1 0 0 1 1 1 1 Dihydroorotate dehydrogenase FMN_dh PF01070.18 ELR17447.1 - 0.0078 15.3 0.4 0.066 12.2 0.4 2.3 2 1 0 2 2 2 1 FMN-dependent dehydrogenase NMO PF03060.15 ELR17447.1 - 0.012 15.0 0.1 0.025 14.0 0.1 1.4 1 0 0 1 1 1 0 Nitronate monooxygenase GTP_EFTU_D3 PF03143.17 ELR17448.1 - 4.6e-21 75.2 0.0 7.7e-21 74.5 0.0 1.4 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU PF00009.27 ELR17448.1 - 2e-13 50.3 0.0 8.5e-06 25.4 0.0 3.3 2 1 1 3 3 3 2 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 ELR17448.1 - 0.0018 18.3 0.0 0.067 13.3 0.0 2.9 2 1 0 2 2 2 1 50S ribosome-binding GTPase C2 PF00168.30 ELR17448.1 - 0.015 15.6 0.0 0.033 14.5 0.0 1.6 1 0 0 1 1 1 0 C2 domain SRPRB PF09439.10 ELR17448.1 - 0.042 13.3 0.0 1.1 8.7 0.0 2.9 3 0 0 3 3 3 0 Signal recognition particle receptor beta subunit Ribosomal_S18 PF01084.20 ELR17449.1 - 3.5e-15 55.9 0.4 1.3e-14 54.2 0.1 2.0 2 0 0 2 2 2 1 Ribosomal protein S18 UBA PF00627.31 ELR17450.1 - 5.1e-27 93.4 1.4 1.5e-15 56.7 0.2 2.6 2 0 0 2 2 2 2 UBA/TS-N domain XPC-binding PF09280.11 ELR17450.1 - 2.3e-21 75.3 13.1 4.3e-21 74.4 13.1 1.5 1 0 0 1 1 1 1 XPC-binding domain ubiquitin PF00240.23 ELR17450.1 - 5.5e-16 58.1 0.3 8.5e-16 57.5 0.3 1.3 1 0 0 1 1 1 1 Ubiquitin family UBA_3 PF09288.10 ELR17450.1 - 0.00026 20.7 0.1 0.19 11.6 0.1 2.6 2 0 0 2 2 2 2 Fungal ubiquitin-associated domain Ubiquitin_4 PF18036.1 ELR17450.1 - 0.007 16.4 2.2 0.03 14.3 2.2 2.0 1 1 0 1 1 1 1 Ubiquitin-like domain DUF2407 PF10302.9 ELR17450.1 - 0.023 15.3 0.0 0.037 14.6 0.0 1.3 1 0 0 1 1 1 0 DUF2407 ubiquitin-like domain Rad60-SLD PF11976.8 ELR17450.1 - 0.054 13.3 0.8 0.091 12.6 0.8 1.4 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like DUF3391 PF11871.8 ELR17450.1 - 0.076 13.5 1.0 0.27 11.8 0.2 2.2 2 1 0 2 2 2 0 Domain of unknown function (DUF3391) DUF3306 PF11748.8 ELR17450.1 - 3 8.7 5.9 0.58 11.0 1.5 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3306) DUF3123 PF11321.8 ELR17450.1 - 6.7 7.4 8.1 4.9 7.9 2.9 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3123) MIP PF00230.20 ELR17451.1 - 4.7e-45 154.0 15.0 1.4e-42 146.0 15.0 2.0 1 1 0 1 1 1 1 Major intrinsic protein Isochorismatase PF00857.20 ELR17452.1 - 1.1e-30 107.1 0.1 1.4e-30 106.8 0.1 1.0 1 0 0 1 1 1 1 Isochorismatase family ELO PF01151.18 ELR17453.1 - 2.6e-51 174.6 21.5 3.2e-51 174.3 21.5 1.0 1 0 0 1 1 1 1 GNS1/SUR4 family Trypan_PARP PF05887.11 ELR17454.1 - 0.0029 17.6 4.0 0.0029 17.6 4.0 5.3 4 1 1 5 5 5 2 Procyclic acidic repetitive protein (PARP) SAPS PF04499.15 ELR17455.1 - 1.2e-10 40.8 0.7 2.3e-10 39.9 0.0 1.7 2 0 0 2 2 2 1 SIT4 phosphatase-associated protein F-box-like PF12937.7 ELR17456.1 - 3.2e-10 39.8 0.8 5.9e-10 38.9 0.8 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ELR17456.1 - 4.4e-08 32.8 0.6 7.4e-08 32.1 0.6 1.3 1 0 0 1 1 1 1 F-box domain DEC-1_N PF04625.13 ELR17456.1 - 0.018 14.1 0.2 0.019 14.0 0.2 1.1 1 0 0 1 1 1 0 DEC-1 protein, N-terminal region ubiquitin PF00240.23 ELR17456.1 - 0.093 12.5 0.0 1.1 9.1 0.0 2.2 1 1 0 1 1 1 0 Ubiquitin family Rap_GAP PF02145.15 ELR17457.1 - 5.5e-19 68.4 0.2 4.6e-16 58.9 0.1 2.3 1 1 0 1 1 1 1 Rap/ran-GAP Lipase_3 PF01764.25 ELR17458.1 - 1.1e-24 86.9 0.0 1.6e-24 86.4 0.0 1.2 1 0 0 1 1 1 1 Lipase (class 3) DUF2974 PF11187.8 ELR17458.1 - 0.092 12.3 0.5 0.59 9.6 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2974) SnoaL_2 PF12680.7 ELR17458.1 - 0.19 12.4 1.3 0.85 10.3 0.2 2.2 1 1 1 2 2 2 0 SnoaL-like domain Abhydrolase_6 PF12697.7 ELR17458.1 - 0.22 12.1 4.9 0.46 11.0 4.6 1.6 1 1 0 1 1 1 0 Alpha/beta hydrolase family Usp PF00582.26 ELR17459.1 - 4.5e-17 62.9 4.4 5e-17 62.7 0.0 2.5 1 1 1 2 2 2 1 Universal stress protein family XAP5 PF04921.14 ELR17459.1 - 0.27 11.0 3.5 0.082 12.7 0.6 1.6 2 0 0 2 2 2 0 XAP5, circadian clock regulator CDC45 PF02724.14 ELR17459.1 - 0.51 8.6 4.3 0.61 8.3 4.3 1.0 1 0 0 1 1 1 0 CDC45-like protein Vault PF01505.18 ELR17460.1 - 5.4e-62 205.7 6.0 8.8e-17 61.0 0.2 4.6 4 0 0 4 4 4 4 Major Vault Protein repeat domain Vault_2 PF17794.1 ELR17460.1 - 1.7e-28 98.8 0.1 4.9e-23 81.3 0.0 2.8 3 0 0 3 3 3 2 Major Vault Protein repeat domain DUF3601 PF12208.8 ELR17460.1 - 4.9e-05 23.3 0.1 1.4 9.1 0.0 3.7 2 1 1 3 3 3 2 Domain of unknown function (DUF3601) DNA_pol_A_exo1 PF01612.20 ELR17461.1 - 2e-30 105.8 0.0 5.7e-25 88.0 0.0 2.2 2 0 0 2 2 2 2 3'-5' exonuclease DUF1635 PF07795.11 ELR17461.1 - 0.24 11.2 3.5 0.53 10.1 3.5 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1635) Stm1_N PF09598.10 ELR17461.1 - 0.46 11.4 0.1 0.46 11.4 0.1 3.2 5 0 0 5 5 5 0 Stm1 CCDC53 PF10152.9 ELR17461.1 - 0.96 9.9 8.7 17 5.8 1.9 3.2 3 0 0 3 3 3 0 Subunit CCDC53 of WASH complex PI3K_1B_p101 PF10486.9 ELR17461.1 - 1.3 6.7 9.1 2.5 5.8 9.1 1.4 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit DUF966 PF06136.13 ELR17461.1 - 8.8 5.9 13.1 0.12 12.1 5.2 1.8 3 0 0 3 3 3 0 Domain of unknown function (DUF966) PPR_2 PF13041.6 ELR17462.1 - 3.9e-19 68.6 0.1 5.7e-07 29.6 0.0 4.8 4 1 1 5 5 5 3 PPR repeat family PPR PF01535.20 ELR17462.1 - 2.2e-13 49.5 0.0 0.0059 16.8 0.0 5.2 5 0 0 5 5 5 3 PPR repeat PPR_3 PF13812.6 ELR17462.1 - 3.2e-13 49.5 0.4 3.5e-06 27.0 0.0 3.9 2 2 1 4 4 4 3 Pentatricopeptide repeat domain PPR_long PF17177.4 ELR17462.1 - 1.4e-06 27.8 0.0 0.082 12.3 0.0 2.4 2 1 1 3 3 3 3 Pentacotripeptide-repeat region of PRORP PPR_1 PF12854.7 ELR17462.1 - 9.2e-06 25.3 0.0 0.37 10.5 0.0 3.6 3 0 0 3 3 3 2 PPR repeat DUF2201_N PF13203.6 ELR17462.1 - 0.028 14.0 0.1 0.039 13.5 0.1 1.2 1 0 0 1 1 1 0 Putative metallopeptidase domain DUF2795 PF11387.8 ELR17462.1 - 0.045 14.0 0.2 9.9 6.5 0.0 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF2795) Imm57 PF15596.6 ELR17462.1 - 0.17 12.2 0.0 3.4 8.1 0.0 2.2 2 0 0 2 2 2 0 Immunity protein 57 Beta_helix PF13229.6 ELR17463.1 - 6.7e-12 45.5 24.7 6.1e-10 39.2 13.1 3.1 1 1 3 4 4 4 3 Right handed beta helix region Cas_Csy3 PF09615.10 ELR17463.1 - 0.074 12.4 0.0 0.68 9.2 0.0 2.0 2 0 0 2 2 2 0 CRISPR-associated protein (Cas_Csy3) PP2C PF00481.21 ELR17464.1 - 1e-30 107.2 2.5 6.8e-30 104.5 0.0 2.8 3 1 0 3 3 3 1 Protein phosphatase 2C PP2C_2 PF13672.6 ELR17464.1 - 9.6e-09 35.2 0.0 9.6e-09 35.2 0.0 1.9 2 0 0 2 2 2 1 Protein phosphatase 2C CDC45 PF02724.14 ELR17464.1 - 9.8 4.3 14.1 14 3.9 14.1 1.2 1 0 0 1 1 1 0 CDC45-like protein CsbD PF05532.12 ELR17465.1 - 0.00085 19.2 4.7 0.002 18.0 4.7 1.7 1 1 0 1 1 1 1 CsbD-like DUF2263 PF10021.9 ELR17466.1 - 3.5e-31 108.6 0.1 1.5e-30 106.5 0.0 2.1 3 0 0 3 3 3 1 Uncharacterized protein conserved in bacteria (DUF2263) GRP PF07172.11 ELR17466.1 - 0.96 10.2 17.6 4.5 8.0 13.1 2.3 2 0 0 2 2 2 0 Glycine rich protein family Pyr_redox_2 PF07992.14 ELR17467.1 - 1.9e-53 181.6 0.9 2.5e-53 181.3 0.9 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.22 ELR17467.1 - 6.7e-24 84.3 0.2 1.5e-23 83.1 0.2 1.6 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox_3 PF13738.6 ELR17467.1 - 9e-16 58.0 0.1 1.4e-15 57.4 0.1 1.3 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 ELR17467.1 - 2.5e-11 44.0 5.3 1.1e-10 42.0 0.1 3.3 3 1 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 ELR17467.1 - 9.7e-08 31.5 1.3 0.00015 21.0 0.0 2.6 2 1 0 3 3 3 2 Glucose inhibited division protein A 3HCDH_N PF02737.18 ELR17467.1 - 4.9e-06 26.5 0.1 0.00078 19.4 0.0 2.4 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain K_oxygenase PF13434.6 ELR17467.1 - 6.7e-06 25.5 0.3 0.0042 16.3 0.0 2.8 2 1 1 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) FAD_oxidored PF12831.7 ELR17467.1 - 6.8e-05 22.4 0.0 0.00013 21.5 0.0 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase DAO PF01266.24 ELR17467.1 - 0.00014 21.6 10.5 0.012 15.2 0.1 4.0 2 2 2 4 4 4 1 FAD dependent oxidoreductase UDPG_MGDP_dh_N PF03721.14 ELR17467.1 - 0.00081 19.0 0.1 0.0027 17.3 0.0 1.9 2 0 0 2 2 2 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain NAD_binding_8 PF13450.6 ELR17467.1 - 0.00094 19.4 2.6 0.053 13.8 0.1 3.1 3 0 0 3 3 3 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 ELR17467.1 - 0.0011 18.2 3.7 0.021 13.9 0.0 3.1 3 1 0 3 3 3 1 FAD binding domain HI0933_like PF03486.14 ELR17467.1 - 0.0032 16.2 5.1 2.3 6.8 0.1 3.9 4 0 0 4 4 4 1 HI0933-like protein AlaDh_PNT_C PF01262.21 ELR17467.1 - 0.0041 16.4 0.1 0.01 15.1 0.1 1.7 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain 2-Hacid_dh_C PF02826.19 ELR17467.1 - 0.0041 16.5 0.0 0.0085 15.5 0.0 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_binding_7 PF13241.6 ELR17467.1 - 0.0042 17.5 0.1 0.01 16.2 0.1 1.7 1 0 0 1 1 1 1 Putative NAD(P)-binding Thi4 PF01946.17 ELR17467.1 - 0.0049 16.1 0.4 0.064 12.5 0.0 2.5 3 0 0 3 3 3 1 Thi4 family XdhC_C PF13478.6 ELR17467.1 - 0.0051 17.3 0.1 0.021 15.3 0.0 2.1 2 0 0 2 2 2 1 XdhC Rossmann domain FAD_binding_3 PF01494.19 ELR17467.1 - 0.0077 15.5 2.3 0.0083 15.4 0.0 2.2 3 0 0 3 3 3 1 FAD binding domain Lycopene_cycl PF05834.12 ELR17467.1 - 0.014 14.5 2.8 0.33 10.0 0.5 2.7 2 1 0 3 3 3 0 Lycopene cyclase protein adh_short PF00106.25 ELR17467.1 - 0.048 13.1 0.2 0.2 11.1 0.0 2.0 2 0 0 2 2 2 0 short chain dehydrogenase GidB PF02527.15 ELR17467.1 - 0.084 12.2 0.0 0.21 10.9 0.0 1.7 1 0 0 1 1 1 0 rRNA small subunit methyltransferase G ubiquitin PF00240.23 ELR17468.1 - 4e-20 71.3 0.7 7e-19 67.4 0.1 2.1 1 1 1 2 2 2 1 Ubiquitin family Rad60-SLD PF11976.8 ELR17468.1 - 1e-07 31.6 0.0 1.8e-07 30.9 0.0 1.4 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 ELR17468.1 - 0.0012 19.2 0.1 0.007 16.8 0.1 2.1 1 1 0 1 1 1 1 Ubiquitin-like domain DUF2407 PF10302.9 ELR17468.1 - 0.073 13.6 0.0 0.14 12.7 0.0 1.5 1 1 0 1 1 1 0 DUF2407 ubiquitin-like domain YjgF_endoribonc PF14588.6 ELR17469.1 - 7.5e-21 74.8 0.0 1.5e-20 73.9 0.0 1.5 1 0 0 1 1 1 1 YjgF/chorismate_mutase-like, putative endoribonuclease Ribonuc_L-PSP PF01042.21 ELR17469.1 - 2.9e-09 37.0 0.0 5.6e-09 36.1 0.0 1.3 1 0 0 1 1 1 1 Endoribonuclease L-PSP zf-C3HC4_3 PF13920.6 ELR17470.1 - 3.1e-15 55.8 11.5 3.1e-15 55.8 11.5 3.1 4 0 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 ELR17470.1 - 4.5e-06 26.4 12.6 4.5e-06 26.4 12.6 3.1 4 0 0 4 4 4 1 Prokaryotic RING finger family 4 zf-RING_2 PF13639.6 ELR17470.1 - 4.1e-05 23.8 13.2 4.1e-05 23.8 13.2 2.9 3 0 0 3 3 3 1 Ring finger domain zf-RING_5 PF14634.6 ELR17470.1 - 0.0066 16.4 14.3 0.0066 16.4 14.3 3.0 4 0 0 4 4 4 1 zinc-RING finger domain DUF1450 PF07293.11 ELR17470.1 - 0.012 15.4 0.7 0.012 15.4 0.7 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1450) Pellino PF04710.14 ELR17470.1 - 0.1 11.3 1.7 0.15 10.7 1.7 1.2 1 0 0 1 1 1 0 Pellino zf-C3HC4_2 PF13923.6 ELR17470.1 - 0.18 11.7 14.3 0.7 9.8 14.3 2.1 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) SIP1 PF04938.12 ELR17471.1 - 1.2e-60 205.0 0.0 1.5e-60 204.6 0.0 1.0 1 0 0 1 1 1 1 Survival motor neuron (SMN) interacting protein 1 (SIP1) FAD_SOX PF18371.1 ELR17471.1 - 0.0066 16.8 0.0 0.014 15.7 0.0 1.5 1 0 0 1 1 1 1 Flavin adenine dinucleotide (FAD)-dependent sulfhydryl oxidase Utp12 PF04003.12 ELR17471.1 - 0.013 15.8 0.4 0.026 14.8 0.4 1.5 1 0 0 1 1 1 0 Dip2/Utp12 Family DUF4254 PF14063.6 ELR17471.1 - 0.023 14.5 0.3 0.038 13.8 0.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4254) AraC_N PF06719.13 ELR17471.1 - 0.031 13.9 0.2 0.049 13.3 0.2 1.3 1 0 0 1 1 1 0 AraC-type transcriptional regulator N-terminus ABATE PF07336.11 ELR17471.1 - 0.072 13.8 1.9 0.1 13.3 0.9 1.8 2 0 0 2 2 2 0 Putative stress-induced transcription regulator DUF3106 PF11304.8 ELR17472.1 - 0.033 14.7 8.0 0.05 14.1 8.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3106) Peptidase_M24 PF00557.24 ELR17474.1 - 5.4e-44 150.4 0.0 7.2e-44 150.0 0.0 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 AMP_N PF05195.16 ELR17474.1 - 8.7e-22 77.1 0.0 1.6e-21 76.3 0.0 1.5 1 0 0 1 1 1 1 Aminopeptidase P, N-terminal domain F-box-like PF12937.7 ELR17475.1 - 0.18 11.7 4.6 0.35 10.8 0.1 2.4 2 0 0 2 2 2 0 F-box-like Rhomboid PF01694.22 ELR17476.1 - 1.6e-21 76.9 7.2 1.6e-21 76.9 7.2 1.7 2 0 0 2 2 2 1 Rhomboid family DUF1751 PF08551.10 ELR17476.1 - 0.0012 19.4 0.1 0.0035 17.9 0.1 1.8 1 0 0 1 1 1 1 Eukaryotic integral membrane protein (DUF1751) DUF3980 PF13140.6 ELR17476.1 - 7.2 7.1 7.1 2.8 8.5 1.8 2.6 2 1 1 3 3 3 0 Domain of unknown function (DUF3980) DUF775 PF05603.12 ELR17477.1 - 1.8e-26 92.9 4.7 6.4e-15 55.2 0.0 2.7 1 1 1 2 2 2 2 Protein of unknown function (DUF775) UFD1 PF03152.14 ELR17478.1 - 7.7e-57 191.5 0.0 1e-56 191.2 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin fusion degradation protein UFD1 Ribosomal_60s PF00428.19 ELR17478.1 - 0.012 16.1 6.2 0.012 16.1 6.2 2.4 2 0 0 2 2 2 0 60s Acidic ribosomal protein Spa1_C PF18218.1 ELR17478.1 - 0.089 13.2 0.1 0.17 12.3 0.1 1.5 1 0 0 1 1 1 0 Lantibiotic immunity protein Spa1 C-terminal domain YscJ_FliF_C PF08345.11 ELR17478.1 - 0.31 11.4 0.2 0.31 11.4 0.2 2.0 1 1 1 2 2 2 0 Flagellar M-ring protein C-terminal PseudoU_synth_2 PF00849.22 ELR17479.1 - 1.2e-21 77.5 1.0 4.6e-21 75.6 0.0 2.4 2 1 0 2 2 2 1 RNA pseudouridylate synthase DUF4604 PF15377.6 ELR17479.1 - 1.3 9.4 22.9 3.7 7.9 4.4 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4604) Lipase_3 PF01764.25 ELR17480.1 - 4e-16 59.2 0.1 1.8e-14 53.8 0.1 2.2 1 1 0 1 1 1 1 Lipase (class 3) DUF2974 PF11187.8 ELR17480.1 - 0.12 11.9 0.5 0.65 9.5 0.5 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF2974) Abhydrolase_6 PF12697.7 ELR17480.1 - 0.19 12.3 3.1 0.29 11.7 3.1 1.4 1 1 0 1 1 1 0 Alpha/beta hydrolase family CoatB PF10389.9 ELR17480.1 - 8.5 6.3 7.0 26 4.8 7.0 1.8 1 0 0 1 1 1 0 Bacteriophage coat protein B C2 PF00168.30 ELR17481.1 - 3.3e-09 36.9 0.0 6.8e-09 35.9 0.0 1.6 1 0 0 1 1 1 1 C2 domain Myotub-related PF06602.14 ELR17482.1 - 9.8e-105 350.3 0.0 1.4e-104 349.8 0.0 1.1 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain Y_phosphatase3 PF13350.6 ELR17482.1 - 0.00028 20.9 0.0 0.00049 20.1 0.0 1.3 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase PF00102.27 ELR17482.1 - 0.012 15.2 0.0 0.023 14.3 0.0 1.4 1 0 0 1 1 1 0 Protein-tyrosine phosphatase HTH_29 PF13551.6 ELR17482.1 - 0.015 15.3 0.2 0.058 13.4 0.0 2.1 2 0 0 2 2 2 0 Winged helix-turn helix 3-PAP PF12578.8 ELR17482.1 - 0.036 13.8 0.0 0.082 12.6 0.0 1.6 1 0 0 1 1 1 0 Myotubularin-associated protein Y_phosphatase2 PF03162.13 ELR17482.1 - 0.083 12.5 0.0 0.18 11.3 0.0 1.5 1 0 0 1 1 1 0 Tyrosine phosphatase family C2 PF00168.30 ELR17483.1 - 1.9e-26 92.3 0.1 3.8e-26 91.4 0.0 1.5 2 0 0 2 2 2 1 C2 domain SH3_4 PF06347.13 ELR17483.1 - 7.9e-06 25.6 0.0 1.7e-05 24.5 0.0 1.5 1 0 0 1 1 1 1 Bacterial SH3 domain SH3_1 PF00018.28 ELR17483.1 - 2.8e-05 23.6 0.0 4.6e-05 22.9 0.0 1.4 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 ELR17483.1 - 0.00095 19.0 0.0 0.0018 18.1 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_3 PF08239.11 ELR17483.1 - 0.0019 18.4 0.1 0.0089 16.3 0.0 2.2 2 0 0 2 2 2 1 Bacterial SH3 domain C2 PF00168.30 ELR17484.1 - 3.3e-20 72.3 0.0 7.9e-20 71.1 0.0 1.7 1 0 0 1 1 1 1 C2 domain BTB PF00651.31 ELR17484.1 - 5.2e-19 68.5 1.2 8.7e-09 35.6 0.5 3.4 3 0 0 3 3 3 3 BTB/POZ domain WWE PF02825.20 ELR17484.1 - 1.4e-05 25.5 1.5 2.9e-05 24.6 1.5 1.6 1 0 0 1 1 1 1 WWE domain MLVIN_C PF18697.1 ELR17484.1 - 0.093 12.8 0.0 0.25 11.5 0.0 1.7 1 0 0 1 1 1 0 Murine leukemia virus (MLV) integrase (IN) C-terminal domain Metallophos PF00149.28 ELR17485.1 - 8.3e-29 101.5 0.2 1e-28 101.2 0.2 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 ELR17485.1 - 0.001 19.5 0.1 0.0029 18.0 0.1 1.8 1 1 0 1 1 1 1 Serine-threonine protein phosphatase N-terminal domain Dicty_CAR PF05462.11 ELR17485.1 - 0.03 13.4 0.0 0.044 12.9 0.0 1.2 1 0 0 1 1 1 0 Slime mold cyclic AMP receptor Glyco_hydro_65N PF03636.15 ELR17485.1 - 0.1 12.2 0.0 0.15 11.7 0.0 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase family 65, N-terminal domain TLD PF07534.16 ELR17486.1 - 0.032 14.5 0.0 0.073 13.3 0.0 1.6 1 1 0 1 1 1 0 TLD DUF3325 PF11804.8 ELR17487.1 - 0.064 13.4 2.3 0.064 13.4 0.5 2.0 3 0 0 3 3 3 0 Protein of unknown function (DUF3325) Rab5ip PF07019.12 ELR17488.1 - 7.5e-20 71.3 9.8 8.7e-20 71.1 9.8 1.1 1 0 0 1 1 1 1 Rab5-interacting protein (Rab5ip) zf-HIT PF04438.16 ELR17489.1 - 3.1e-09 36.5 16.2 5.1e-09 35.9 16.2 1.4 1 0 0 1 1 1 1 HIT zinc finger Sel1 PF08238.12 ELR17490.1 - 4.1e-13 49.5 12.6 3.4e-05 24.4 0.1 5.3 5 0 0 5 5 5 3 Sel1 repeat U-box PF04564.15 ELR17490.1 - 2.8e-08 33.8 0.0 6.9e-08 32.6 0.0 1.7 1 0 0 1 1 1 1 U-box domain zf-NOSIP PF15906.5 ELR17490.1 - 0.021 15.0 0.0 0.046 13.9 0.0 1.5 1 0 0 1 1 1 0 Zinc-finger of nitric oxide synthase-interacting protein KASH_CCD PF14662.6 ELR17490.1 - 0.12 12.2 17.5 0.91 9.3 6.1 2.2 1 1 1 2 2 2 0 Coiled-coil region of CCDC155 or KASH TPR_6 PF13174.6 ELR17490.1 - 0.18 12.5 5.9 67 4.4 0.0 4.7 5 0 0 5 5 3 0 Tetratricopeptide repeat SHE3 PF17078.5 ELR17490.1 - 0.3 10.8 4.3 0.57 9.9 4.3 1.5 1 0 0 1 1 1 0 SWI5-dependent HO expression protein 3 MbeD_MobD PF04899.12 ELR17490.1 - 0.66 10.1 3.9 11 6.2 0.6 2.7 2 0 0 2 2 2 0 MbeD/MobD like DUF812 PF05667.11 ELR17490.1 - 0.92 8.3 16.3 1.4 7.7 16.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF812) Lin-8 PF03353.15 ELR17490.1 - 1.3 8.6 4.3 3.4 7.1 4.3 1.8 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist V_ATPase_I PF01496.19 ELR17490.1 - 1.7 6.5 6.5 2.4 6.0 6.5 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Spc7 PF08317.11 ELR17490.1 - 2 7.2 23.2 2 7.2 7.1 2.2 1 1 1 2 2 2 0 Spc7 kinetochore protein CENP-F_leu_zip PF10473.9 ELR17490.1 - 3.5 7.7 21.7 5.6 7.0 4.6 3.2 1 1 2 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Baculo_PEP_C PF04513.12 ELR17490.1 - 3.5 7.7 4.9 8.9 6.3 0.2 2.4 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Fib_alpha PF08702.10 ELR17490.1 - 5.2 7.3 7.7 1.5 9.0 2.3 2.2 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family Laminin_II PF06009.12 ELR17490.1 - 5.4 7.0 11.5 16 5.5 5.0 2.4 2 0 0 2 2 2 0 Laminin Domain II DUF4446 PF14584.6 ELR17490.1 - 6.3 6.8 6.3 1.2 9.1 0.3 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF4446) Fez1 PF06818.15 ELR17490.1 - 7.4 7.0 19.1 6.5 7.2 16.8 2.0 1 1 1 2 2 2 0 Fez1 Nup54_57_C PF18570.1 ELR17490.1 - 7.6 6.2 7.4 13 5.5 0.1 3.4 3 0 0 3 3 3 0 NUP57/Nup54 C-terminal domain Sel1 PF08238.12 ELR17491.1 - 1.3e-19 70.2 12.7 7e-05 23.4 0.1 5.9 5 0 0 5 5 5 4 Sel1 repeat U-box PF04564.15 ELR17491.1 - 2.5e-07 30.8 0.0 9.1e-07 29.0 0.0 2.1 1 1 0 1 1 1 1 U-box domain zf-NOSIP PF15906.5 ELR17491.1 - 0.00015 21.8 0.0 0.00063 19.8 0.0 2.0 2 0 0 2 2 2 1 Zinc-finger of nitric oxide synthase-interacting protein zf-Nse PF11789.8 ELR17491.1 - 0.00028 20.6 0.0 0.00061 19.6 0.0 1.5 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit AAA_13 PF13166.6 ELR17491.1 - 0.071 11.7 10.1 0.1 11.2 10.1 1.1 1 0 0 1 1 1 0 AAA domain SHE3 PF17078.5 ELR17491.1 - 0.2 11.4 9.5 0.33 10.6 9.5 1.3 1 0 0 1 1 1 0 SWI5-dependent HO expression protein 3 GAS PF13851.6 ELR17491.1 - 0.26 10.6 26.2 0.017 14.5 13.4 2.8 1 1 2 3 3 3 0 Growth-arrest specific micro-tubule binding UPF0242 PF06785.11 ELR17491.1 - 0.56 10.3 21.2 2.6 8.1 1.8 2.3 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus APG6_N PF17675.1 ELR17491.1 - 1 9.9 32.2 0.5 10.9 25.2 2.9 1 1 1 2 2 2 0 Apg6 coiled-coil region NPV_P10 PF05531.12 ELR17491.1 - 4.5 7.8 8.3 0.52 10.8 0.7 3.0 2 1 0 3 3 3 0 Nucleopolyhedrovirus P10 protein HAUS-augmin3 PF14932.6 ELR17491.1 - 5.8 6.4 23.1 2.9 7.4 16.9 2.3 1 1 1 2 2 2 0 HAUS augmin-like complex subunit 3 Sec34 PF04136.15 ELR17491.1 - 6.7 6.6 12.3 3.8 7.4 5.7 2.3 1 1 1 2 2 2 0 Sec34-like family Seryl_tRNA_N PF02403.22 ELR17491.1 - 8.1 6.7 20.8 1.8 8.8 8.0 4.1 2 1 2 4 4 4 0 Seryl-tRNA synthetase N-terminal domain Atg14 PF10186.9 ELR17491.1 - 8.3 5.4 22.1 2.2 7.3 6.3 2.4 1 1 1 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 XhlA PF10779.9 ELR17491.1 - 9.7 6.5 5.6 33 4.8 0.2 2.6 2 0 0 2 2 2 0 Haemolysin XhlA Metallophos PF00149.28 ELR17492.1 - 1.4e-09 38.8 0.6 1.8e-09 38.4 0.6 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 ELR17492.1 - 0.083 13.1 0.4 0.41 10.8 0.4 2.1 1 1 0 1 1 1 0 Calcineurin-like phosphoesterase superfamily domain Cofilin_ADF PF00241.20 ELR17493.1 - 7.1e-28 96.9 0.1 8.1e-28 96.7 0.1 1.0 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein Arf PF00025.21 ELR17495.1 - 8.1e-71 237.1 0.0 1.1e-70 236.7 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 ELR17495.1 - 4.6e-15 55.9 0.0 6.7e-15 55.4 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase G-alpha PF00503.20 ELR17495.1 - 2.1e-12 46.9 0.3 2.4e-08 33.6 0.1 2.3 1 1 1 2 2 2 2 G-protein alpha subunit Ras PF00071.22 ELR17495.1 - 9.1e-12 44.9 0.0 1.2e-11 44.5 0.0 1.1 1 0 0 1 1 1 1 Ras family SRPRB PF09439.10 ELR17495.1 - 1.3e-10 41.0 0.0 1.8e-10 40.5 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 ELR17495.1 - 4.9e-09 35.9 0.0 6.5e-09 35.5 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 ELR17495.1 - 4.7e-05 23.4 0.0 0.0001 22.3 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase MeaB PF03308.16 ELR17495.1 - 0.0055 15.7 0.2 0.2 10.6 0.1 2.6 2 1 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB cobW PF02492.19 ELR17495.1 - 0.025 14.2 0.1 4 7.0 0.0 2.2 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain ABC_tran PF00005.27 ELR17495.1 - 0.067 13.7 0.1 0.12 12.9 0.1 1.5 1 1 0 1 1 1 0 ABC transporter AAA_18 PF13238.6 ELR17495.1 - 0.13 12.8 0.0 0.22 12.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain Ras PF00071.22 ELR17497.1 - 3.1e-52 176.4 0.0 3.5e-52 176.3 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR17497.1 - 4e-19 69.0 0.0 6.1e-19 68.4 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR17497.1 - 1.8e-08 34.1 0.0 2e-08 33.9 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 ELR17497.1 - 1.2e-06 28.2 0.0 5.6e-06 26.0 0.0 1.8 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain ATP_bind_1 PF03029.17 ELR17497.1 - 1.7e-06 28.0 0.2 4.5e-05 23.3 0.0 2.0 1 1 1 2 2 2 1 Conserved hypothetical ATP binding protein RsgA_GTPase PF03193.16 ELR17497.1 - 0.00033 20.6 0.0 0.56 10.1 0.0 2.1 2 0 0 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 ELR17497.1 - 0.00063 19.8 0.0 0.00092 19.3 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 ELR17497.1 - 0.0075 15.8 0.0 0.043 13.3 0.0 2.0 1 1 0 1 1 1 1 Ferrous iron transport protein B ParA PF10609.9 ELR17497.1 - 0.072 12.5 0.0 0.78 9.1 0.0 2.0 2 0 0 2 2 2 0 NUBPL iron-transfer P-loop NTPase MMR_HSR1_Xtn PF16897.5 ELR17497.1 - 0.09 12.8 0.0 0.14 12.2 0.0 1.4 1 0 0 1 1 1 0 C-terminal region of MMR_HSR1 domain IstB_IS21 PF01695.17 ELR17497.1 - 0.15 11.8 0.0 0.26 11.0 0.0 1.3 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_16 PF13191.6 ELR17497.1 - 0.21 12.0 0.0 0.31 11.4 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain DUF1712 PF08217.11 ELR17498.1 - 1.4e-74 251.7 3.5 1.3e-51 175.9 0.0 3.0 2 1 1 3 3 3 3 Fungal domain of unknown function (DUF1712) Lipase_3 PF01764.25 ELR17499.1 - 2.8e-16 59.7 0.1 1.4e-14 54.2 0.1 2.2 1 1 0 1 1 1 1 Lipase (class 3) DUF2974 PF11187.8 ELR17499.1 - 0.097 12.2 0.5 0.52 9.8 0.5 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF2974) Abhydrolase_6 PF12697.7 ELR17499.1 - 0.21 12.2 3.8 0.34 11.5 3.7 1.4 1 1 0 1 1 1 0 Alpha/beta hydrolase family DSPc PF00782.20 ELR17500.1 - 9.6e-32 109.6 0.0 2.2e-29 101.9 0.0 2.2 2 0 0 2 2 2 2 Dual specificity phosphatase, catalytic domain Rhodanese PF00581.20 ELR17500.1 - 9.3e-07 29.3 0.0 5.5e-06 26.8 0.0 2.2 2 0 0 2 2 2 1 Rhodanese-like domain PTPlike_phytase PF14566.6 ELR17500.1 - 0.0012 19.0 0.0 0.0022 18.1 0.0 1.3 1 0 0 1 1 1 1 Inositol hexakisphosphate Y_phosphatase PF00102.27 ELR17500.1 - 0.0051 16.4 0.0 0.0088 15.6 0.0 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase SPX PF03105.19 ELR17500.1 - 0.018 15.0 0.7 0.028 14.3 0.7 1.4 1 0 0 1 1 1 0 SPX domain Init_tRNA_PT PF04179.12 ELR17500.1 - 0.025 14.9 0.0 0.049 13.9 0.0 1.4 1 0 0 1 1 1 0 Rit1 DUSP-like domain SOG2 PF10428.9 ELR17500.1 - 0.11 11.7 5.9 3.1 6.9 2.2 2.0 2 0 0 2 2 2 0 RAM signalling pathway protein DUF908 PF06012.12 ELR17500.1 - 0.71 9.2 4.7 3.1 7.1 0.4 2.2 2 0 0 2 2 2 0 Domain of Unknown Function (DUF908) Rrn6 PF10214.9 ELR17500.1 - 0.77 8.2 14.5 2.8 6.3 14.5 1.7 1 1 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor CCDC53 PF10152.9 ELR17500.1 - 1.1 9.7 3.1 3.8 7.9 1.1 2.1 2 0 0 2 2 2 0 Subunit CCDC53 of WASH complex Macoilin PF09726.9 ELR17501.1 - 0.48 8.9 5.8 0.62 8.5 5.8 1.1 1 0 0 1 1 1 0 Macoilin family Myb_DNA-binding PF00249.31 ELR17502.1 - 0.01 16.0 0.1 0.01 16.0 0.1 2.6 3 1 0 3 3 3 0 Myb-like DNA-binding domain BAF1_ABF1 PF04684.13 ELR17502.1 - 0.077 12.0 2.6 0.11 11.6 2.6 1.2 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor NAM-associated PF14303.6 ELR17503.1 - 0.1 13.3 3.4 0.3 11.8 3.3 1.8 2 0 0 2 2 2 0 No apical meristem-associated C-terminal domain Rrn6 PF10214.9 ELR17503.1 - 0.11 11.0 4.8 0.23 9.9 4.8 1.4 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor Lactamase_B_2 PF12706.7 ELR17504.1 - 9.5e-35 119.9 0.0 1.4e-34 119.4 0.0 1.2 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 ELR17504.1 - 1.4e-09 38.1 0.0 2e-09 37.6 0.0 1.2 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B PF00753.27 ELR17504.1 - 0.037 14.0 0.1 0.18 11.8 0.0 2.1 2 0 0 2 2 2 0 Metallo-beta-lactamase superfamily tRNA-synt_2 PF00152.20 ELR17505.1 - 6.7e-79 265.2 0.0 1.4e-78 264.2 0.0 1.5 2 0 0 2 2 2 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 ELR17505.1 - 7.7e-08 32.2 1.4 1.5e-07 31.3 1.4 1.5 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.20 ELR17505.1 - 0.0028 17.2 0.8 1.3 8.4 0.0 3.0 3 0 0 3 3 3 2 tRNA synthetases class II core domain (F) NPV_P10 PF05531.12 ELR17505.1 - 0.023 15.1 1.1 0.023 15.1 1.1 2.4 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein TACC_C PF05010.14 ELR17505.1 - 0.18 11.6 11.5 1.2 8.9 2.3 2.9 3 0 0 3 3 3 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal AATF-Che1 PF13339.6 ELR17505.1 - 0.24 12.1 11.0 0.073 13.8 3.8 2.4 2 0 0 2 2 2 0 Apoptosis antagonizing transcription factor DUF724 PF05266.14 ELR17505.1 - 2.3 8.0 12.1 7.1 6.4 1.6 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF724) DUF4407 PF14362.6 ELR17505.1 - 2.6 7.3 15.0 2.8 7.2 1.9 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) DUF2203 PF09969.9 ELR17505.1 - 3.5 8.4 11.2 9.9 6.9 2.6 2.9 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2203) THOC7 PF05615.13 ELR17505.1 - 5.7 7.2 14.2 9.7 6.5 2.9 2.5 2 0 0 2 2 2 0 Tho complex subunit 7 DUF3138 PF11336.8 ELR17505.1 - 5.9 5.4 8.4 1.1 7.8 2.3 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3138) Caroten_synth PF04240.12 ELR17506.1 - 0.2 11.5 2.1 0.86 9.4 0.6 2.0 2 0 0 2 2 2 0 Carotenoid biosynthesis protein CDP-OH_P_transf PF01066.21 ELR17508.1 - 2.3e-11 44.3 0.3 2.3e-11 44.3 0.3 3.6 3 1 0 3 3 3 1 CDP-alcohol phosphatidyltransferase PEN-2 PF10251.9 ELR17508.1 - 0.34 11.4 3.6 1.2 9.6 3.6 1.9 1 0 0 1 1 1 0 Presenilin enhancer-2 subunit of gamma secretase zf-CCHC_4 PF14392.6 ELR17509.1 - 0.95 9.3 9.0 3.9 7.3 1.6 2.3 2 0 0 2 2 2 0 Zinc knuckle DNA_pol_B PF00136.21 ELR17510.1 - 1e-110 370.6 0.0 2.5e-82 277.0 0.0 2.2 1 1 1 2 2 2 2 DNA polymerase family B zf-DNA_Pol PF08996.10 ELR17510.1 - 2.2e-40 138.4 0.9 4e-40 137.5 0.9 1.4 1 0 0 1 1 1 1 DNA Polymerase alpha zinc finger DNA_pol_B_exo1 PF03104.19 ELR17510.1 - 4.6e-35 121.4 0.0 7e-35 120.8 0.0 1.3 1 0 0 1 1 1 1 DNA polymerase family B, exonuclease domain DNA_pol_B_2 PF03175.13 ELR17510.1 - 0.0069 15.3 0.0 0.014 14.3 0.0 1.5 1 0 0 1 1 1 1 DNA polymerase type B, organellar and viral PAGK PF15284.6 ELR17510.1 - 0.078 12.9 0.0 0.19 11.7 0.0 1.6 1 0 0 1 1 1 0 Phage-encoded virulence factor TPR_17 PF13431.6 ELR17511.1 - 2e-06 27.8 5.1 1.2 9.7 0.0 4.4 4 0 0 4 4 3 3 Tetratricopeptide repeat TPR_19 PF14559.6 ELR17511.1 - 0.00017 22.0 2.2 0.0026 18.3 0.4 3.6 1 1 0 2 2 2 1 Tetratricopeptide repeat TPR_16 PF13432.6 ELR17511.1 - 0.00031 21.3 12.3 0.0016 19.0 0.2 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 ELR17511.1 - 0.0024 17.9 13.3 0.0057 16.7 0.6 4.8 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_14 PF13428.6 ELR17511.1 - 0.0025 18.5 13.4 0.51 11.3 0.1 5.3 2 1 3 5 5 4 2 Tetratricopeptide repeat SBF2 PF12335.8 ELR17511.1 - 0.016 14.9 7.1 0.57 9.7 0.0 3.3 3 0 0 3 3 2 0 Myotubularin protein TPR_7 PF13176.6 ELR17511.1 - 0.026 14.5 4.8 0.15 12.2 0.1 4.3 4 0 0 4 4 3 0 Tetratricopeptide repeat Ssu72 PF04722.13 ELR17511.1 - 0.03 13.9 0.0 0.059 12.9 0.0 1.4 1 0 0 1 1 1 0 Ssu72-like protein TPR_1 PF00515.28 ELR17511.1 - 0.034 14.0 0.5 0.034 14.0 0.5 4.0 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_12 PF13424.6 ELR17511.1 - 0.22 11.8 10.5 0.65 10.3 4.4 3.9 3 1 1 4 4 3 0 Tetratricopeptide repeat RRXRR PF14239.6 ELR17511.1 - 0.34 10.7 6.5 0.24 11.3 1.7 2.6 2 0 0 2 2 2 0 RRXRR protein TPR_8 PF13181.6 ELR17511.1 - 0.43 10.9 9.5 2.8 8.4 0.3 4.3 4 0 0 4 4 3 0 Tetratricopeptide repeat HMG_box_5 PF14887.6 ELR17511.1 - 3.9 7.5 6.3 13 5.9 0.1 3.0 2 0 0 2 2 2 0 HMG (high mobility group) box 5 TPR_10 PF13374.6 ELR17511.1 - 4.6 7.2 10.4 3.4 7.7 0.2 5.0 5 0 0 5 5 5 0 Tetratricopeptide repeat tRNA-synt_1d PF00750.19 ELR17512.1 - 1.8e-103 346.2 2.5 2.5e-103 345.7 2.5 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (R) DALR_1 PF05746.15 ELR17512.1 - 4.7e-25 88.1 0.4 1e-24 87.0 0.4 1.6 1 0 0 1 1 1 1 DALR anticodon binding domain Arg_tRNA_synt_N PF03485.16 ELR17512.1 - 3.5e-07 30.7 0.0 9.3e-07 29.4 0.0 1.8 1 0 0 1 1 1 1 Arginyl tRNA synthetase N terminal domain Ribonucleas_3_3 PF14622.6 ELR17513.1 - 2.6e-26 92.3 0.0 5.4e-26 91.2 0.0 1.6 1 0 0 1 1 1 1 Ribonuclease-III-like zf-H2C2_2 PF13465.6 ELR17513.1 - 2.3e-17 62.6 22.3 1.2e-06 28.7 0.3 4.9 4 0 0 4 4 4 4 Zinc-finger double domain Ribonuclease_3 PF00636.26 ELR17513.1 - 4.8e-14 52.8 0.0 2.6e-13 50.5 0.0 2.4 1 0 0 1 1 1 1 Ribonuclease III domain zf-C2H2 PF00096.26 ELR17513.1 - 2e-13 50.0 19.2 2.4e-05 24.5 0.1 5.0 4 0 0 4 4 4 4 Zinc finger, C2H2 type BET PF17035.5 ELR17513.1 - 2.9e-13 49.8 0.0 1e-12 48.1 0.1 2.0 2 0 0 2 2 2 1 Bromodomain extra-terminal - transcription regulation dsrm PF00035.26 ELR17513.1 - 5.6e-08 33.4 0.1 2.6e-07 31.2 0.0 2.3 2 0 0 2 2 1 1 Double-stranded RNA binding motif zf-H2C2_5 PF13909.6 ELR17513.1 - 0.00023 20.8 14.4 0.024 14.4 0.3 4.7 4 0 0 4 4 4 2 C2H2-type zinc-finger domain zf-met PF12874.7 ELR17513.1 - 0.0004 20.7 0.2 0.0004 20.7 0.2 3.5 4 0 0 4 4 3 1 Zinc-finger of C2H2 type zf-C2H2_4 PF13894.6 ELR17513.1 - 0.001 19.7 23.4 0.02 15.7 0.1 5.2 4 1 0 4 4 4 3 C2H2-type zinc finger SHOCT PF09851.9 ELR17513.1 - 0.001 18.7 0.1 0.001 18.7 0.1 2.0 2 0 0 2 2 1 1 Short C-terminal domain zf-C2H2_jaz PF12171.8 ELR17513.1 - 0.0065 16.7 7.3 0.019 15.3 0.0 3.0 3 0 0 3 3 3 1 Zinc-finger double-stranded RNA-binding GvpG PF05120.12 ELR17513.1 - 0.0072 16.3 0.8 0.021 14.9 0.8 1.8 1 0 0 1 1 1 1 Gas vesicle protein G DUF2716 PF10898.8 ELR17513.1 - 0.14 12.6 2.7 0.34 11.3 2.7 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2716) GAGA PF09237.11 ELR17513.1 - 0.21 11.4 1.5 7.4 6.5 0.1 2.8 2 0 0 2 2 2 0 GAGA factor zf-C2HE PF16278.5 ELR17513.1 - 0.32 11.5 3.6 56 4.3 3.6 3.1 1 1 0 1 1 1 0 C2HE / C2H2 / C2HC zinc-binding finger zf-C2H2_6 PF13912.6 ELR17513.1 - 0.45 10.6 4.9 1 9.4 0.1 2.9 2 0 0 2 2 2 0 C2H2-type zinc finger FAM212 PF15342.6 ELR17513.1 - 4.4 7.2 7.0 2.3 8.1 0.0 3.7 4 0 0 4 4 4 0 FAM212 family Phosducin PF02114.16 ELR17514.1 - 1.2e-26 93.3 0.1 1.4e-26 93.0 0.1 1.0 1 0 0 1 1 1 1 Phosducin Amidinotransf PF02274.17 ELR17514.1 - 0.029 13.5 0.0 0.029 13.5 0.0 1.5 2 0 0 2 2 2 0 Amidinotransferase L27_N PF09060.10 ELR17514.1 - 0.093 12.8 0.1 0.23 11.6 0.1 1.6 1 0 0 1 1 1 0 L27_N HEAT PF02985.22 ELR17515.1 - 3.8e-53 172.9 42.6 0.00071 19.6 0.0 26.2 28 0 0 28 28 27 12 HEAT repeat HEAT_EZ PF13513.6 ELR17515.1 - 8.3e-40 134.7 66.3 2.1e-05 24.9 0.1 25.7 23 2 5 28 28 27 11 HEAT-like repeat HEAT_2 PF13646.6 ELR17515.1 - 8.1e-38 128.7 49.4 0.00012 22.4 0.1 16.8 14 4 2 16 16 15 11 HEAT repeats Cnd1 PF12717.7 ELR17515.1 - 4.3e-25 88.6 6.1 0.0079 16.2 0.0 11.1 6 2 4 11 11 11 5 non-SMC mitotic condensation complex subunit 1 CLASP_N PF12348.8 ELR17515.1 - 3.5e-17 62.7 0.4 0.094 12.3 0.0 8.9 4 2 5 9 9 9 6 CLASP N terminal Vac14_Fab1_bd PF12755.7 ELR17515.1 - 5e-13 49.5 0.1 0.064 13.9 0.0 11.1 9 2 3 12 12 12 1 Vacuolar 14 Fab1-binding region Adaptin_N PF01602.20 ELR17515.1 - 7.8e-13 47.8 19.0 0.016 13.8 0.1 8.5 8 1 0 8 8 8 5 Adaptin N terminal region TFCD_C PF12612.8 ELR17515.1 - 6.5e-06 26.1 2.8 0.017 15.0 0.0 5.7 5 0 0 5 5 5 1 Tubulin folding cofactor D C terminal IFRD PF05004.13 ELR17515.1 - 2.8e-05 23.4 28.4 1.2 8.2 0.0 10.3 9 4 2 11 11 11 3 Interferon-related developmental regulator (IFRD) MMS19_C PF12460.8 ELR17515.1 - 0.00027 20.2 18.7 5.1 6.1 0.0 10.0 9 2 3 12 12 12 1 RNAPII transcription regulator C-terminal Dopey_N PF04118.14 ELR17515.1 - 0.0003 20.0 0.6 6.3 5.8 0.0 5.6 4 1 0 4 4 4 1 Dopey, N-terminal Arm PF00514.23 ELR17515.1 - 0.00038 20.4 5.3 26 5.1 0.1 8.2 8 0 0 8 8 6 0 Armadillo/beta-catenin-like repeat Ecm29 PF13001.7 ELR17515.1 - 0.00058 18.7 11.9 0.14 10.9 0.0 6.4 8 2 1 9 9 9 2 Proteasome stabiliser ParcG PF10274.9 ELR17515.1 - 0.0041 17.2 2.6 51 3.9 0.0 6.4 6 1 1 7 7 7 0 Parkin co-regulated protein DUF2798 PF11391.8 ELR17515.1 - 0.024 14.7 1.6 0.063 13.3 1.6 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2798) Ribosomal_60s PF00428.19 ELR17515.1 - 0.098 13.3 6.1 0.94 10.1 6.1 2.8 1 0 0 1 1 1 0 60s Acidic ribosomal protein FAD-SLDH PF12318.8 ELR17515.1 - 0.24 11.5 2.1 1.8 8.6 0.5 3.3 3 0 0 3 3 3 0 Membrane bound FAD containing D-sorbitol dehydrogenase Lys PF00062.20 ELR17516.1 - 7.1e-06 26.3 2.2 1.7e-05 25.0 2.2 1.7 1 1 0 1 1 1 1 C-type lysozyme/alpha-lactalbumin family SLT PF01464.20 ELR17516.1 - 2.3e-05 24.0 0.0 2.8e-05 23.7 0.0 1.2 1 0 0 1 1 1 1 Transglycosylase SLT domain CBM49 PF09478.10 ELR17517.1 - 2e-09 37.6 0.1 0.037 14.3 0.0 4.0 3 1 0 3 3 3 3 Carbohydrate binding domain CBM49 DASH_Hsk3 PF08227.11 ELR17518.1 - 0.0067 16.8 0.1 0.016 15.5 0.1 1.6 1 0 0 1 1 1 1 DASH complex subunit Hsk3 like TRPM_tetra PF16519.5 ELR17518.1 - 4.4 7.5 5.2 1.6 8.9 0.1 2.6 3 0 0 3 3 3 0 Tetramerisation domain of TRPM SKA2 PF16740.5 ELR17518.1 - 5.3 6.9 10.9 0.68 9.7 3.7 2.7 1 1 2 3 3 3 0 Spindle and kinetochore-associated protein 2 Spectrin PF00435.21 ELR17518.1 - 7.2 7.2 9.5 0.91 10.0 1.8 2.8 2 1 0 2 2 2 0 Spectrin repeat PX PF00787.24 ELR17519.1 - 5.4e-08 32.8 0.0 7.2e-08 32.4 0.0 1.1 1 0 0 1 1 1 1 PX domain Zn_clus PF00172.18 ELR17520.1 - 4.7e-07 29.8 11.1 6.7e-07 29.3 11.1 1.2 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain SDA1 PF05285.12 ELR17520.1 - 0.6 9.5 7.9 0.96 8.8 7.9 1.2 1 0 0 1 1 1 0 SDA1 SPRY PF00622.28 ELR17523.1 - 5e-17 62.1 0.0 9.1e-17 61.3 0.0 1.4 1 0 0 1 1 1 1 SPRY domain BACK PF07707.15 ELR17523.1 - 4.6e-07 29.9 0.4 0.00021 21.4 0.2 2.2 2 0 0 2 2 2 2 BTB And C-terminal Kelch LVIVD PF08309.11 ELR17523.1 - 0.073 12.4 0.0 0.14 11.5 0.0 1.5 1 0 0 1 1 1 0 LVIVD repeat CYTH PF01928.21 ELR17524.1 - 0.0007 19.6 0.0 0.0011 19.0 0.0 1.2 1 0 0 1 1 1 1 CYTH domain DEAD PF00270.29 ELR17525.1 - 1.7e-36 125.7 0.0 1.4e-35 122.6 0.0 2.3 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ELR17525.1 - 8.9e-27 93.6 0.0 3.5e-26 91.7 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 ELR17525.1 - 4.3e-06 26.8 0.0 4.3e-06 26.8 0.0 3.4 4 0 0 4 4 4 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 ELR17525.1 - 0.011 16.0 0.1 0.053 13.8 0.1 2.2 1 1 0 1 1 1 0 AAA domain LAP1C PF05609.12 ELR17525.1 - 0.99 8.4 32.3 0.28 10.2 7.4 2.3 2 0 0 2 2 2 0 Lamina-associated polypeptide 1C (LAP1C) Peptidase_C48 PF02902.19 ELR17526.1 - 4.7e-09 36.4 0.0 6.1e-09 36.0 0.0 1.2 1 0 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain PB1 PF00564.24 ELR17528.1 - 1.2e-05 25.2 0.3 6.4e-05 22.8 0.2 2.2 3 0 0 3 3 3 1 PB1 domain SAM_1 PF00536.30 ELR17528.1 - 0.022 15.2 0.1 1.5 9.4 0.0 2.6 3 0 0 3 3 3 0 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 ELR17528.1 - 0.055 13.6 0.0 0.16 12.1 0.0 1.9 2 1 0 2 2 2 0 SAM domain (Sterile alpha motif) 2OG-FeII_Oxy_2 PF13532.6 ELR17529.1 - 2.9e-11 43.9 0.0 5.6e-11 43.0 0.0 1.4 1 1 1 2 2 2 1 2OG-Fe(II) oxygenase superfamily Cmc1 PF08583.10 ELR17530.1 - 0.013 15.6 2.4 0.013 15.6 2.4 1.7 2 0 0 2 2 2 0 Cytochrome c oxidase biogenesis protein Cmc1 like CHCH PF06747.13 ELR17530.1 - 0.02 15.0 5.1 0.18 12.0 0.4 2.4 2 0 0 2 2 2 0 CHCH domain SRCR PF00530.18 ELR17530.1 - 0.11 13.1 1.1 0.18 12.3 1.1 1.5 1 1 0 1 1 1 0 Scavenger receptor cysteine-rich domain TMA7 PF09072.10 ELR17530.1 - 2.2 9.2 5.8 2.9 8.8 4.7 1.7 1 1 0 1 1 1 0 Translation machinery associated TMA7 DUF3128 PF11326.8 ELR17530.1 - 4.9 7.6 10.6 0.29 11.5 3.5 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3128) WD40 PF00400.32 ELR17531.1 - 1.8e-11 44.4 13.6 0.029 15.2 0.1 5.5 4 1 1 5 5 5 4 WD domain, G-beta repeat PQQ_3 PF13570.6 ELR17531.1 - 0.0046 17.4 0.8 11 6.7 0.0 4.0 4 0 0 4 4 4 1 PQQ-like domain PQQ_2 PF13360.6 ELR17531.1 - 0.0075 15.9 0.1 0.14 11.7 0.0 2.7 3 0 0 3 3 3 1 PQQ-like domain ANAPC4_WD40 PF12894.7 ELR17531.1 - 0.028 14.7 0.1 8.6 6.7 0.0 3.9 3 2 1 4 4 4 0 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ELR17531.1 - 0.11 11.7 0.0 0.37 10.1 0.0 1.8 3 0 0 3 3 3 0 WD40-like domain Ank_2 PF12796.7 ELR17532.1 - 2e-31 108.4 0.9 7.6e-15 55.3 0.0 3.7 4 1 1 5 5 4 2 Ankyrin repeats (3 copies) CLU PF13236.6 ELR17532.1 - 5.4e-29 101.6 0.0 1.2e-28 100.5 0.0 1.5 1 0 0 1 1 1 1 Clustered mitochondria Ank_4 PF13637.6 ELR17532.1 - 7.1e-29 99.8 1.9 2.5e-10 40.7 0.0 5.1 2 2 3 5 5 5 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 ELR17532.1 - 2.4e-26 88.9 0.4 2.1e-06 27.6 0.0 5.9 5 0 0 5 5 5 4 Ankyrin repeat Ank PF00023.30 ELR17532.1 - 9.3e-25 86.0 1.0 5.2e-07 29.8 0.5 6.2 5 1 0 5 5 5 4 Ankyrin repeat Ank_5 PF13857.6 ELR17532.1 - 1e-22 79.9 2.0 1.5e-08 34.7 0.3 3.8 2 1 1 3 3 3 3 Ankyrin repeats (many copies) eIF3_p135 PF12807.7 ELR17532.1 - 1.3e-08 35.1 0.8 3.9e-08 33.5 0.3 2.0 2 0 0 2 2 2 1 Translation initiation factor eIF3 subunit 135 TPR_19 PF14559.6 ELR17532.1 - 0.00016 22.2 2.7 0.031 14.8 0.2 3.0 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_12 PF13424.6 ELR17532.1 - 0.013 15.7 3.5 0.013 15.7 3.5 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_8 PF13181.6 ELR17532.1 - 0.08 13.2 8.7 0.49 10.7 0.2 4.6 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_14 PF13428.6 ELR17532.1 - 0.17 12.8 5.7 16 6.6 0.1 4.5 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_17 PF13431.6 ELR17532.1 - 0.32 11.5 3.3 8.9 6.9 0.0 4.1 4 0 0 4 4 4 0 Tetratricopeptide repeat MIT PF04212.18 ELR17532.1 - 0.55 10.3 9.9 0.38 10.8 1.1 3.5 3 1 0 3 3 3 0 MIT (microtubule interacting and transport) domain PRP38 PF03371.15 ELR17533.1 - 2.1e-53 180.8 0.0 2.8e-53 180.3 0.0 1.2 1 0 0 1 1 1 1 PRP38 family DUF974 PF06159.13 ELR17534.1 - 1.5e-36 126.5 0.2 1.2e-35 123.5 0.2 2.1 1 1 0 1 1 1 1 Protein of unknown function (DUF974) Trs65 PF12735.7 ELR17534.1 - 0.00026 20.5 0.2 0.011 15.2 0.0 2.9 3 1 0 3 3 3 1 TRAPP trafficking subunit Trs65 UPF0561 PF10573.9 ELR17534.1 - 0.086 13.0 0.0 0.14 12.2 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised protein family UPF0561 RasGAP PF00616.19 ELR17535.1 - 1.8e-26 93.1 0.0 2.9e-23 82.7 0.0 3.3 2 1 0 2 2 2 1 GTPase-activator protein for Ras-like GTPase Peptidase_M3 PF01432.20 ELR17536.1 - 4.6e-55 187.7 0.8 9.8e-55 186.6 0.0 1.8 3 0 0 3 3 3 1 Peptidase family M3 Trigger_C PF05698.14 ELR17536.1 - 0.13 12.3 0.9 0.26 11.3 0.9 1.4 1 0 0 1 1 1 0 Bacterial trigger factor protein (TF) C-terminus Peptidase_M3 PF01432.20 ELR17537.1 - 2.1e-76 258.0 0.3 2.4e-76 257.8 0.3 1.0 1 0 0 1 1 1 1 Peptidase family M3 Peptidase_M50B PF13398.6 ELR17537.1 - 0.13 11.9 0.0 0.24 11.0 0.0 1.4 1 0 0 1 1 1 0 Peptidase M50B-like Ras PF00071.22 ELR17538.1 - 1.7e-39 135.1 0.1 2e-39 134.8 0.1 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR17538.1 - 8.9e-21 74.3 0.0 1.3e-20 73.8 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR17538.1 - 1.4e-09 37.7 0.0 1.7e-09 37.4 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 ELR17538.1 - 0.011 15.2 0.5 3.6 7.1 0.1 2.2 1 1 1 2 2 2 0 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 ELR17538.1 - 0.027 14.5 0.1 0.041 14.0 0.1 1.5 1 1 0 1 1 1 0 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 ELR17538.1 - 0.075 12.4 0.1 0.094 12.1 0.1 1.2 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region SRPRB PF09439.10 ELR17538.1 - 0.12 11.8 0.0 0.15 11.5 0.0 1.2 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit RsgA_GTPase PF03193.16 ELR17538.1 - 0.16 11.9 0.4 16 5.4 0.0 2.1 2 0 0 2 2 2 0 RsgA GTPase Cas9_REC PF16592.5 ELR17538.1 - 0.26 10.0 0.0 0.3 9.8 0.0 1.0 1 0 0 1 1 1 0 REC lobe of CRISPR-associated endonuclease Cas9 Arrestin_C PF02752.22 ELR17539.1 - 9.8e-05 22.8 0.4 0.00017 22.1 0.4 1.5 1 1 0 1 1 1 1 Arrestin (or S-antigen), C-terminal domain DUF5549 PF17703.1 ELR17540.1 - 0.073 12.7 2.5 0.044 13.4 1.0 1.4 1 1 0 1 1 1 0 Family of unknown function (DUF5549) Vpu PF00558.19 ELR17541.1 - 0.0076 16.0 0.2 0.016 15.0 0.2 1.5 1 0 0 1 1 1 1 Vpu protein SieB PF14163.6 ELR17541.1 - 0.087 12.3 0.8 0.16 11.4 0.2 1.7 2 0 0 2 2 2 0 Super-infection exclusion protein B Ras PF00071.22 ELR17542.1 - 5e-54 182.3 0.2 5.9e-54 182.0 0.2 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR17542.1 - 2.8e-34 117.9 0.0 4.3e-34 117.3 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR17542.1 - 6.8e-14 51.7 0.0 8.5e-14 51.4 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 ELR17542.1 - 5.5e-05 23.1 0.0 0.017 15.1 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase Gtr1_RagA PF04670.12 ELR17542.1 - 0.00038 19.9 0.0 0.00069 19.0 0.0 1.4 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 ELR17542.1 - 0.0011 19.0 0.0 0.0018 18.3 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 ELR17542.1 - 0.0035 16.9 0.1 0.014 15.0 0.1 1.8 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain SRPRB PF09439.10 ELR17542.1 - 0.0049 16.3 0.0 0.0077 15.7 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit AAA_22 PF13401.6 ELR17542.1 - 0.0066 16.7 0.0 0.026 14.8 0.0 1.9 1 1 1 2 2 2 1 AAA domain TniB PF05621.11 ELR17542.1 - 0.012 15.0 0.0 0.25 10.8 0.0 2.1 2 0 0 2 2 2 0 Bacterial TniB protein PduV-EutP PF10662.9 ELR17542.1 - 0.013 15.3 0.0 5.5 6.7 0.0 2.3 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_16 PF13191.6 ELR17542.1 - 0.031 14.6 0.1 0.048 14.1 0.1 1.7 1 1 0 1 1 1 0 AAA ATPase domain NACHT PF05729.12 ELR17542.1 - 0.042 13.8 0.0 0.074 13.0 0.0 1.4 1 0 0 1 1 1 0 NACHT domain AAA_5 PF07728.14 ELR17542.1 - 0.067 13.2 0.0 0.13 12.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_33 PF13671.6 ELR17542.1 - 0.11 12.7 0.0 0.16 12.1 0.0 1.5 1 1 0 1 1 1 0 AAA domain Septin PF00735.18 ELR17542.1 - 0.13 11.5 0.0 0.22 10.8 0.0 1.3 1 0 0 1 1 1 0 Septin AAA_29 PF13555.6 ELR17542.1 - 0.16 11.7 0.0 0.36 10.6 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain ABC_tran PF00005.27 ELR17542.1 - 0.18 12.3 0.0 0.2 12.2 0.0 1.5 1 1 0 1 1 1 0 ABC transporter G-alpha PF00503.20 ELR17542.1 - 0.21 10.7 0.0 25 3.9 0.0 2.8 1 1 1 2 2 2 0 G-protein alpha subunit PBD PF00786.28 ELR17543.1 - 8.2e-15 54.9 0.1 2e-14 53.7 0.1 1.7 1 0 0 1 1 1 1 P21-Rho-binding domain WH2 PF02205.20 ELR17543.1 - 0.0067 16.2 0.0 0.012 15.4 0.0 1.4 1 0 0 1 1 1 1 WH2 motif ssDNA_DBD PF18333.1 ELR17544.1 - 0.069 13.3 1.5 0.069 13.3 1.5 1.9 2 0 0 2 2 2 0 Non-canonical single-stranded DNA-binding domain Sec16_N PF12935.7 ELR17544.1 - 0.12 12.5 8.3 0.16 12.1 8.2 1.2 1 1 0 1 1 1 0 Vesicle coat trafficking protein Sec16 N-terminus DUF4407 PF14362.6 ELR17544.1 - 1.1 8.6 16.9 1.5 8.1 16.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) SKG6 PF08693.10 ELR17545.1 - 0.0037 16.6 4.9 0.0037 16.6 4.9 2.3 2 0 0 2 2 2 1 Transmembrane alpha-helix domain TMEM154 PF15102.6 ELR17545.1 - 0.3 11.0 0.0 0.3 11.0 0.0 2.0 2 0 0 2 2 2 0 TMEM154 protein family SKG6 PF08693.10 ELR17546.1 - 0.0053 16.1 5.1 0.0053 16.1 5.1 2.2 2 0 0 2 2 2 1 Transmembrane alpha-helix domain TMEM154 PF15102.6 ELR17546.1 - 0.15 11.9 1.4 0.18 11.7 0.0 1.8 2 0 0 2 2 2 0 TMEM154 protein family Aldo_ket_red PF00248.21 ELR17547.1 - 9.9e-22 77.5 0.0 1.8e-21 76.7 0.0 1.4 1 0 0 1 1 1 1 Aldo/keto reductase family HMG-CoA_red PF00368.18 ELR17548.1 - 1.2e-145 485.2 2.3 1.4e-145 484.9 2.3 1.1 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A reductase Alpha_kinase PF02816.18 ELR17549.1 - 5e-42 144.1 0.0 7.3e-42 143.6 0.0 1.2 1 0 0 1 1 1 1 Alpha-kinase family Trypsin_2 PF13365.6 ELR17549.1 - 6.8e-14 53.0 0.0 1.4e-13 52.0 0.0 1.6 1 0 0 1 1 1 1 Trypsin-like peptidase domain Peptidase_S39 PF02122.15 ELR17549.1 - 0.01 15.4 0.1 0.023 14.2 0.1 1.6 1 1 0 1 1 1 0 Peptidase S39 SH3_2 PF07653.17 ELR17549.1 - 0.022 14.5 0.0 0.74 9.5 0.0 2.4 2 0 0 2 2 2 0 Variant SH3 domain MFS_1 PF07690.16 ELR17550.1 - 5.9e-31 107.7 49.0 2.1e-24 86.1 21.7 2.8 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 ELR17550.1 - 8.6e-09 34.8 24.0 1.9e-05 23.7 11.1 3.1 2 1 0 2 2 2 2 Sugar (and other) transporter DUF4133 PF13571.6 ELR17550.1 - 1.6 9.1 5.0 1.2 9.5 0.7 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4133) Cytochrom_B558a PF05038.13 ELR17550.1 - 9.6 5.7 9.8 8.7 5.9 0.2 3.1 3 0 0 3 3 3 0 Cytochrome Cytochrome b558 alpha-subunit MFS_1 PF07690.16 ELR17551.1 - 2.1e-47 161.8 46.2 2.1e-47 161.8 46.2 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 ELR17551.1 - 2.9e-16 59.4 10.2 2.9e-16 59.4 10.2 2.5 2 1 0 2 2 2 1 Sugar (and other) transporter MFS_3 PF05977.13 ELR17551.1 - 1.7 6.9 15.3 3.2 6.0 15.3 1.5 1 1 0 1 1 1 0 Transmembrane secretion effector Cyclin PF08613.11 ELR17552.1 - 0.0061 16.9 0.9 0.0094 16.3 0.9 1.6 1 1 0 1 1 1 1 Cyclin Cyclin_N PF00134.23 ELR17552.1 - 0.13 12.0 2.2 0.34 10.6 0.2 2.5 2 0 0 2 2 2 0 Cyclin, N-terminal domain PI3Ka PF00613.20 ELR17553.1 - 0.0014 18.1 0.1 0.0022 17.4 0.1 1.4 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) KxDL PF10241.9 ELR17553.1 - 0.0026 18.0 0.7 0.03 14.6 0.1 2.5 1 1 2 3 3 3 1 Uncharacterized conserved protein DASH_Duo1 PF08651.10 ELR17553.1 - 0.01 15.6 1.0 0.82 9.5 0.2 2.3 2 0 0 2 2 2 0 DASH complex subunit Duo1 DUF948 PF06103.11 ELR17553.1 - 0.033 14.4 1.3 0.31 11.3 0.5 2.2 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) ABC_tran_CTD PF16326.5 ELR17553.1 - 0.048 13.9 2.8 0.71 10.2 1.0 2.8 1 1 1 2 2 2 0 ABC transporter C-terminal domain BLOC1_2 PF10046.9 ELR17553.1 - 0.066 13.5 3.1 6.9 7.0 0.4 2.3 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Laminin_II PF06009.12 ELR17553.1 - 0.12 12.4 2.1 3.2 7.8 0.4 2.2 1 1 1 2 2 2 0 Laminin Domain II CENP-F_leu_zip PF10473.9 ELR17553.1 - 0.17 11.9 3.6 0.49 10.4 3.6 1.8 1 1 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Snapin_Pallidin PF14712.6 ELR17553.1 - 0.21 12.0 1.8 3.5 8.1 0.1 2.6 1 1 2 3 3 3 0 Snapin/Pallidin DUF2203 PF09969.9 ELR17553.1 - 0.33 11.7 1.4 19 6.0 0.1 2.2 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2203) TrbI_Ftype PF09677.10 ELR17553.1 - 0.53 10.6 2.9 16 5.9 0.2 2.2 1 1 1 2 2 2 0 Type-F conjugative transfer system protein (TrbI_Ftype) zf-RING_2 PF13639.6 ELR17554.1 - 1.5e-09 38.1 4.8 2.2e-09 37.5 4.8 1.3 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.7 ELR17554.1 - 1.6e-07 31.5 5.9 2.4e-07 31.0 5.9 1.3 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_2 PF13923.6 ELR17554.1 - 7.4e-06 25.7 7.6 1.2e-05 25.0 7.6 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 ELR17554.1 - 1.1e-05 25.2 6.2 1.6e-05 24.6 6.2 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 ELR17554.1 - 9.8e-05 22.3 2.0 0.00016 21.7 2.0 1.3 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger Prok-RING_4 PF14447.6 ELR17554.1 - 0.00032 20.5 2.2 0.0005 19.9 2.2 1.3 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_11 PF17123.5 ELR17554.1 - 0.00036 20.2 0.4 0.00071 19.3 0.4 1.5 1 0 0 1 1 1 1 RING-like zinc finger zf-RING_5 PF14634.6 ELR17554.1 - 0.00039 20.3 3.2 0.00059 19.7 3.2 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 ELR17554.1 - 0.0078 16.2 2.0 0.013 15.5 2.0 1.4 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 ELR17554.1 - 0.021 14.7 3.5 0.032 14.1 3.5 1.2 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Tmpp129 PF10272.9 ELR17554.1 - 0.053 12.8 0.4 0.062 12.6 0.4 1.2 1 0 0 1 1 1 0 Putative transmembrane protein precursor Zn_ribbon_17 PF17120.5 ELR17554.1 - 0.18 11.5 3.8 0.22 11.2 3.1 1.5 1 1 0 1 1 1 0 Zinc-ribbon, C4HC2 type START PF01852.19 ELR17555.1 - 9.5e-18 64.4 0.0 1.2e-17 64.0 0.0 1.0 1 0 0 1 1 1 1 START domain dCache_1 PF02743.18 ELR17556.1 - 2.4e-06 27.5 0.2 3e-06 27.2 0.2 1.2 1 0 0 1 1 1 1 Cache domain YdfZ PF14001.6 ELR17556.1 - 0.044 14.2 0.1 0.17 12.3 0.1 1.9 2 0 0 2 2 2 0 YdfZ protein RabGAP-TBC PF00566.18 ELR17557.1 - 2.3e-50 171.2 0.6 2.3e-50 171.2 0.6 2.0 2 0 0 2 2 2 1 Rab-GTPase-TBC domain GRAM PF02893.20 ELR17557.1 - 3.5e-07 30.1 0.0 1.4e-06 28.1 0.0 2.0 2 0 0 2 2 2 1 GRAM domain RNA_pol_3_Rpc31 PF11705.8 ELR17557.1 - 0.67 10.2 15.7 4.7 7.4 5.5 2.8 2 0 0 2 2 2 0 DNA-directed RNA polymerase III subunit Rpc31 PDZ_3 PF17815.1 ELR17558.1 - 2.8e-36 124.5 0.0 6e-36 123.5 0.0 1.6 2 0 0 2 2 2 1 PDZ domain Trypsin_2 PF13365.6 ELR17558.1 - 3.2e-11 44.4 0.1 9.2e-11 42.8 0.1 1.9 1 0 0 1 1 1 1 Trypsin-like peptidase domain PDZ PF00595.24 ELR17558.1 - 9e-07 29.2 1.1 1.3e-05 25.4 0.1 2.6 2 0 0 2 2 2 1 PDZ domain PDZ_2 PF13180.6 ELR17558.1 - 5.8e-06 26.5 0.3 0.00011 22.4 0.0 2.6 2 1 0 2 2 2 1 PDZ domain PDZ_6 PF17820.1 ELR17558.1 - 0.00036 20.3 0.5 0.078 12.8 0.0 2.7 2 0 0 2 2 2 2 PDZ domain Trypsin PF00089.26 ELR17558.1 - 0.014 15.2 0.0 0.034 13.9 0.0 1.7 1 0 0 1 1 1 0 Trypsin TTSSLRR PF12468.8 ELR17558.1 - 0.09 13.0 0.4 0.24 11.7 0.4 1.6 1 0 0 1 1 1 0 Type III secretion system leucine rich repeat protein DUF3228 PF11539.8 ELR17559.1 - 7.8e-85 283.3 0.0 8.7e-85 283.1 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3228) DUF4566 PF15130.6 ELR17559.1 - 0.18 11.2 0.0 0.22 10.9 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4566) Cellulase PF00150.18 ELR17560.1 - 5.8e-38 130.9 0.8 7.4e-38 130.6 0.8 1.1 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) MSA-2c PF12238.8 ELR17560.1 - 9.1 6.2 12.7 17 5.4 12.7 1.4 1 0 0 1 1 1 0 Merozoite surface antigen 2c adh_short PF00106.25 ELR17561.1 - 8e-17 61.3 0.0 2.2e-11 43.6 0.0 2.3 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 ELR17561.1 - 1.5e-16 60.7 0.1 7.8e-08 32.2 0.2 2.3 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ELR17561.1 - 0.0077 16.2 0.0 0.018 14.9 0.0 1.5 1 0 0 1 1 1 1 KR domain zf-MYND PF01753.18 ELR17562.1 - 4.8e-10 39.4 13.5 8.3e-10 38.6 13.5 1.4 1 0 0 1 1 1 1 MYND finger zf-C6H2 PF15801.5 ELR17562.1 - 0.009 16.3 8.0 0.019 15.3 8.0 1.6 1 1 0 1 1 1 1 zf-MYND-like zinc finger, mRNA-binding DUF2015 PF09435.10 ELR17562.1 - 0.15 11.9 0.0 0.25 11.2 0.0 1.3 1 0 0 1 1 1 0 Fungal protein of unknown function (DUF2015) Mucin PF01456.17 ELR17563.1 - 0.0041 17.1 1.6 0.0041 17.1 1.6 1.9 2 0 0 2 2 2 1 Mucin-like glycoprotein LRIF1 PF15741.5 ELR17563.1 - 0.29 9.6 26.4 0.32 9.5 26.4 1.0 1 0 0 1 1 1 0 Ligand-dependent nuclear receptor-interacting factor 1 LAP1C PF05609.12 ELR17563.1 - 3.3 6.7 30.2 4.1 6.4 30.2 1.2 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) SR-25 PF10500.9 ELR17563.1 - 4.5 6.8 51.5 1.3 8.6 23.7 2.1 1 1 1 2 2 2 0 Nuclear RNA-splicing-associated protein AF-4 PF05110.13 ELR17563.1 - 9.4 4.2 35.7 11 4.0 35.7 1.0 1 0 0 1 1 1 0 AF-4 proto-oncoprotein Ycf1 PF05758.12 ELR17564.1 - 0.018 13.0 0.3 0.018 13.0 0.3 1.5 2 0 0 2 2 2 0 Ycf1 Hamartin PF04388.12 ELR17564.1 - 0.024 13.4 11.3 0.032 12.9 11.3 1.2 1 0 0 1 1 1 0 Hamartin protein CMD PF02627.20 ELR17564.1 - 0.061 13.4 0.6 6.2 7.0 0.1 2.5 1 1 1 2 2 2 0 Carboxymuconolactone decarboxylase family Myb_DNA-binding PF00249.31 ELR17564.1 - 0.095 12.9 0.1 0.2 11.9 0.1 1.5 1 0 0 1 1 1 0 Myb-like DNA-binding domain ThiD2 PF17792.1 ELR17564.1 - 2.1 8.8 5.6 0.6 10.6 0.6 2.1 1 1 1 2 2 2 0 ThiD2 family SRP-alpha_N PF04086.13 ELR17564.1 - 6.7 6.5 28.5 10 5.9 28.5 1.3 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal DUF4551 PF15087.6 ELR17564.1 - 9.4 4.9 11.0 9.4 4.9 11.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) DUF2559 PF10832.8 ELR17565.1 - 0.059 13.5 0.2 0.16 12.1 0.2 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2559) MS_channel PF00924.18 ELR17566.1 - 2.6e-19 69.6 2.6 4.7e-19 68.7 2.6 1.4 1 0 0 1 1 1 1 Mechanosensitive ion channel MMPL PF03176.15 ELR17566.1 - 0.45 9.4 2.1 0.88 8.4 2.1 1.4 1 0 0 1 1 1 0 MMPL family PIN_4 PF13638.6 ELR17568.1 - 3e-22 79.3 0.1 2.1e-21 76.6 0.0 2.3 2 0 0 2 2 2 1 PIN domain PIN_9 PF18477.1 ELR17568.1 - 0.013 15.8 0.0 0.055 13.8 0.0 2.1 1 1 0 1 1 1 0 PIN like domain RE_Eco29kI PF09517.10 ELR17568.1 - 0.11 12.2 0.0 0.2 11.3 0.0 1.4 1 0 0 1 1 1 0 Eco29kI restriction endonuclease RhoGEF PF00621.20 ELR17569.1 - 5.3e-33 114.8 0.3 1.6e-32 113.2 0.3 1.9 1 0 0 1 1 1 1 RhoGEF domain Arm PF00514.23 ELR17569.1 - 1.3e-10 40.9 12.9 0.054 13.6 0.0 6.9 7 0 0 7 7 7 3 Armadillo/beta-catenin-like repeat Arm_2 PF04826.13 ELR17569.1 - 6.7e-06 25.7 2.8 0.013 15.0 2.5 3.1 2 1 1 3 3 3 2 Armadillo-like IQ_SEC7_PH PF16453.5 ELR17569.1 - 0.00011 22.2 0.7 0.00027 20.9 0.0 1.9 2 0 0 2 2 2 1 PH domain HEAT_EZ PF13513.6 ELR17569.1 - 0.00025 21.5 3.9 0.0067 16.9 0.2 4.4 3 1 1 4 4 4 1 HEAT-like repeat PH PF00169.29 ELR17569.1 - 0.0017 18.8 0.0 0.0037 17.7 0.0 1.6 1 0 0 1 1 1 1 PH domain WAPL PF07814.13 ELR17569.1 - 0.0061 15.4 0.6 0.48 9.2 0.0 2.8 1 1 1 2 2 2 1 Wings apart-like protein regulation of heterochromatin SEN1_N PF12726.7 ELR17569.1 - 0.0084 14.4 3.3 0.14 10.4 0.8 2.3 1 1 0 2 2 2 2 SEN1 N terminal WD40 PF00400.32 ELR17570.1 - 1.3e-09 38.5 11.6 0.013 16.3 1.1 6.5 6 1 0 6 6 6 4 WD domain, G-beta repeat Dynein_IC2 PF11540.8 ELR17570.1 - 0.0077 16.2 0.2 0.089 12.8 0.0 2.7 3 0 0 3 3 3 1 Cytoplasmic dynein 1 intermediate chain 2 ANAPC4_WD40 PF12894.7 ELR17570.1 - 0.11 12.9 0.0 0.9 9.9 0.0 2.5 2 1 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain PLA2G12 PF06951.11 ELR17572.1 - 5.3e-23 81.9 17.6 7.3e-23 81.4 17.6 1.1 1 0 0 1 1 1 1 Group XII secretory phospholipase A2 precursor (PLA2G12) Phospholip_A2_3 PF09056.11 ELR17572.1 - 3e-05 24.6 8.0 6.8e-05 23.5 8.0 1.5 1 1 0 1 1 1 1 Prokaryotic phospholipase A2 SF3b1 PF08920.10 ELR17574.1 - 1.2e-43 148.4 28.5 4.4e-42 143.3 4.3 3.7 1 1 2 3 3 3 2 Splicing factor 3B subunit 1 HEAT PF02985.22 ELR17574.1 - 3e-10 39.5 6.1 1.1 9.7 0.0 8.1 8 0 0 8 8 8 2 HEAT repeat HEAT_2 PF13646.6 ELR17574.1 - 1.2e-08 35.3 4.4 0.058 13.8 0.0 7.2 5 2 2 8 8 8 3 HEAT repeats HEAT_EZ PF13513.6 ELR17574.1 - 2.8e-06 27.7 5.5 0.28 11.7 0.0 7.0 7 2 1 8 8 8 2 HEAT-like repeat Cnd1 PF12717.7 ELR17574.1 - 4.7e-06 26.8 8.4 0.67 10.0 0.0 6.5 7 1 0 7 7 7 3 non-SMC mitotic condensation complex subunit 1 Dopey_N PF04118.14 ELR17574.1 - 0.00075 18.7 1.5 0.72 8.9 0.0 4.3 4 1 0 4 4 4 1 Dopey, N-terminal Adaptin_N PF01602.20 ELR17574.1 - 0.00082 18.0 3.7 0.7 8.4 0.0 3.4 2 1 1 3 3 3 2 Adaptin N terminal region DUF3385 PF11865.8 ELR17574.1 - 0.0018 18.2 2.5 3.2 7.7 0.4 5.1 4 1 0 4 4 4 1 Domain of unknown function (DUF3385) CLASP_N PF12348.8 ELR17574.1 - 0.0027 17.3 1.9 1.3 8.5 0.1 2.8 3 0 0 3 3 3 2 CLASP N terminal NUC173 PF08161.12 ELR17574.1 - 0.0074 16.0 0.3 1.5 8.4 0.0 4.1 3 1 0 4 4 4 1 NUC173 domain Vac14_Fab1_bd PF12755.7 ELR17574.1 - 0.017 15.7 1.3 2.3 8.9 0.0 4.5 5 0 0 5 5 5 0 Vacuolar 14 Fab1-binding region Ribosomal_L7Ae PF01248.26 ELR17575.1 - 1.5e-25 88.8 0.0 1.7e-25 88.5 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family WD40 PF00400.32 ELR17578.1 - 4.5e-17 62.1 12.0 6.2e-07 30.0 1.6 6.3 6 0 0 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ELR17578.1 - 6.9e-13 48.7 1.7 0.0029 17.9 0.1 4.7 3 2 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Cytochrom_D1 PF02239.16 ELR17578.1 - 1.3e-05 24.0 0.3 0.11 11.0 0.0 2.7 1 1 2 3 3 3 3 Cytochrome D1 heme domain eIF2A PF08662.11 ELR17578.1 - 0.0037 17.2 0.0 0.51 10.2 0.0 2.3 2 0 0 2 2 2 1 Eukaryotic translation initiation factor eIF2A PHTB1_N PF14727.6 ELR17578.1 - 0.013 14.9 0.0 6 6.1 0.0 3.0 2 1 1 3 3 3 0 PTHB1 N-terminus Frtz PF11768.8 ELR17578.1 - 0.017 13.4 0.0 0.041 12.2 0.0 1.5 2 0 0 2 2 2 0 WD repeat-containing and planar cell polarity effector protein Fritz Ge1_WD40 PF16529.5 ELR17578.1 - 0.055 12.4 0.0 3.3 6.6 0.0 2.9 2 1 1 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein RhoGEF PF00621.20 ELR17579.1 - 6.5e-51 173.2 0.1 1.2e-50 172.3 0.1 1.4 1 0 0 1 1 1 1 RhoGEF domain PH PF00169.29 ELR17579.1 - 0.016 15.7 0.2 0.051 14.1 0.2 1.9 1 0 0 1 1 1 0 PH domain DUF4611 PF15387.6 ELR17579.1 - 0.45 10.8 6.6 3.2 8.0 0.5 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4611) CENP-B_dimeris PF09026.10 ELR17579.1 - 4.6 7.7 7.5 2.9 8.3 4.0 2.2 2 0 0 2 2 2 0 Centromere protein B dimerisation domain Renin_r PF07850.14 ELR17580.1 - 4.8 7.9 14.2 4.7 7.9 0.1 3.9 4 1 0 4 4 4 0 Renin receptor-like protein PAS PF00989.25 ELR17581.1 - 0.056 13.5 0.0 0.12 12.4 0.0 1.5 1 0 0 1 1 1 0 PAS fold PAS_9 PF13426.7 ELR17581.1 - 0.15 12.3 0.0 0.34 11.2 0.0 1.5 1 0 0 1 1 1 0 PAS domain AAA PF00004.29 ELR17582.1 - 1.8e-18 67.2 0.0 3.2e-18 66.4 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 ELR17582.1 - 8.3e-06 26.3 1.5 0.00021 21.7 0.0 2.9 1 1 2 3 3 3 1 AAA ATPase domain RuvB_N PF05496.12 ELR17582.1 - 4.8e-05 23.2 0.0 8.8e-05 22.3 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain ATPase_2 PF01637.18 ELR17582.1 - 0.00013 22.0 0.0 0.00023 21.1 0.0 1.4 1 0 0 1 1 1 1 ATPase domain predominantly from Archaea NACHT PF05729.12 ELR17582.1 - 0.00024 21.1 0.0 0.055 13.4 0.0 2.5 2 0 0 2 2 2 1 NACHT domain AAA_22 PF13401.6 ELR17582.1 - 0.00038 20.8 0.5 0.0025 18.1 0.1 2.6 2 1 0 2 2 2 1 AAA domain AAA_28 PF13521.6 ELR17582.1 - 0.00075 19.8 0.1 0.0034 17.6 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.6 ELR17582.1 - 0.00094 19.7 0.0 0.0032 18.0 0.0 1.9 2 0 0 2 2 2 1 AAA domain AAA_14 PF13173.6 ELR17582.1 - 0.001 19.1 0.0 0.0028 17.7 0.0 1.7 1 1 0 1 1 1 1 AAA domain RNA_helicase PF00910.22 ELR17582.1 - 0.0011 19.4 0.0 0.003 17.9 0.0 1.7 2 0 0 2 2 1 1 RNA helicase F-box PF00646.33 ELR17582.1 - 0.0029 17.4 2.1 0.015 15.2 2.1 2.2 1 1 0 1 1 1 1 F-box domain F-box-like PF12937.7 ELR17582.1 - 0.0048 16.8 0.1 0.015 15.2 0.1 1.9 1 0 0 1 1 1 1 F-box-like TsaE PF02367.17 ELR17582.1 - 0.0049 16.9 0.0 0.011 15.7 0.0 1.5 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE Rad17 PF03215.15 ELR17582.1 - 0.021 14.8 0.0 0.038 13.9 0.0 1.5 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_5 PF07728.14 ELR17582.1 - 0.023 14.7 0.1 0.077 13.0 0.0 1.9 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_lid_3 PF17862.1 ELR17582.1 - 0.024 14.4 0.0 0.057 13.2 0.0 1.6 1 0 0 1 1 1 0 AAA+ lid domain AAA_33 PF13671.6 ELR17582.1 - 0.031 14.5 0.0 0.15 12.2 0.0 2.2 1 1 0 1 1 1 0 AAA domain ABC_tran PF00005.27 ELR17582.1 - 0.036 14.6 0.0 0.14 12.7 0.0 1.9 2 1 1 3 3 3 0 ABC transporter DUF815 PF05673.13 ELR17582.1 - 0.036 13.2 0.0 0.067 12.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_25 PF13481.6 ELR17582.1 - 0.1 12.1 0.1 0.7 9.4 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_24 PF13479.6 ELR17582.1 - 0.12 12.1 0.0 0.24 11.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain NTPase_1 PF03266.15 ELR17582.1 - 0.15 11.9 0.0 0.29 11.1 0.0 1.5 1 0 0 1 1 1 0 NTPase dNK PF01712.19 ELR17582.1 - 0.18 11.7 0.0 0.3 10.9 0.0 1.4 1 0 0 1 1 1 0 Deoxynucleoside kinase Myotub-related PF06602.14 ELR17583.1 - 4.3e-49 167.3 7.0 1.1e-29 103.5 3.0 2.2 1 1 1 2 2 2 2 Myotubularin-like phosphatase domain Pkinase_Tyr PF07714.17 ELR17583.1 - 6.1e-46 156.8 0.0 8.2e-45 153.1 0.0 2.3 1 1 0 1 1 1 1 Protein tyrosine kinase COR PF16095.5 ELR17583.1 - 1.2e-45 155.7 0.0 2.9e-45 154.5 0.0 1.7 2 0 0 2 2 2 1 C-terminal of Roc, COR, domain Pkinase PF00069.25 ELR17583.1 - 4.1e-35 121.4 0.0 9.5e-35 120.2 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain LRR_8 PF13855.6 ELR17583.1 - 4.2e-35 119.3 33.5 4e-11 42.5 0.1 6.1 4 2 2 6 6 6 6 Leucine rich repeat WD40 PF00400.32 ELR17583.1 - 4.6e-27 93.7 11.1 2.1e-05 25.2 0.4 7.2 6 0 0 6 6 6 4 WD domain, G-beta repeat LRR_4 PF12799.7 ELR17583.1 - 2.5e-22 78.6 27.4 0.001 19.4 0.0 8.4 5 3 5 10 10 10 8 Leucine Rich repeats (2 copies) Roc PF08477.13 ELR17583.1 - 6.4e-18 65.1 0.0 1.2e-16 61.0 0.0 2.9 2 1 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase PH PF00169.29 ELR17583.1 - 5.8e-11 42.8 0.0 1.6e-10 41.4 0.0 1.8 1 0 0 1 1 1 1 PH domain LRR_1 PF00560.33 ELR17583.1 - 1.8e-05 24.6 22.0 0.065 13.8 0.1 8.8 10 1 0 10 10 7 1 Leucine Rich Repeat Ras PF00071.22 ELR17583.1 - 3.3e-05 23.5 0.0 7.1e-05 22.5 0.0 1.6 1 0 0 1 1 1 1 Ras family ANAPC4_WD40 PF12894.7 ELR17583.1 - 0.00012 22.3 0.7 0.026 14.8 0.2 3.7 2 2 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain LRR_9 PF14580.6 ELR17583.1 - 0.0011 18.5 7.6 0.033 13.7 1.0 3.5 2 1 2 4 4 4 1 Leucine-rich repeat MMR_HSR1 PF01926.23 ELR17583.1 - 0.0033 17.5 0.0 0.0096 16.0 0.0 1.8 1 0 0 1 1 1 1 50S ribosome-binding GTPase LRR_6 PF13516.6 ELR17583.1 - 0.0074 16.3 27.8 4.1 7.7 0.0 8.8 10 0 0 10 10 9 1 Leucine Rich repeat PH_8 PF15409.6 ELR17583.1 - 0.032 14.5 0.1 0.087 13.1 0.1 1.8 1 0 0 1 1 1 0 Pleckstrin homology domain PH_11 PF15413.6 ELR17583.1 - 0.053 14.0 0.8 0.11 12.9 0.1 2.0 2 0 0 2 2 1 0 Pleckstrin homology domain PH_3 PF14593.6 ELR17583.1 - 0.13 12.4 0.0 0.35 11.0 0.0 1.7 1 0 0 1 1 1 0 PH domain SGT1 PF07093.11 ELR17583.1 - 4.6 5.6 13.6 8 4.8 13.6 1.3 1 0 0 1 1 1 0 SGT1 protein DUF4763 PF15960.5 ELR17584.1 - 0.00029 20.3 9.4 0.021 14.2 7.1 2.1 2 0 0 2 2 2 2 Domain of unknown function (DUF4763) CENP-Q PF13094.6 ELR17584.1 - 0.00042 20.6 1.7 0.00042 20.6 1.7 2.1 2 0 0 2 2 2 1 CENP-Q, a CENPA-CAD centromere complex subunit Leu_zip PF15294.6 ELR17584.1 - 0.0038 16.8 0.7 0.0059 16.2 0.7 1.3 1 0 0 1 1 1 1 Leucine zipper PAS_9 PF13426.7 ELR17584.1 - 0.013 15.8 0.0 0.029 14.6 0.0 1.6 1 0 0 1 1 1 0 PAS domain AT_hook PF02178.19 ELR17584.1 - 0.046 13.6 4.2 0.12 12.4 4.2 1.7 1 0 0 1 1 1 0 AT hook motif ZapB PF06005.12 ELR17584.1 - 0.095 13.2 6.1 0.25 11.8 6.1 1.6 1 0 0 1 1 1 0 Cell division protein ZapB Jnk-SapK_ap_N PF09744.9 ELR17584.1 - 0.12 12.6 6.2 0.26 11.5 6.2 1.5 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 DUF1664 PF07889.12 ELR17584.1 - 0.3 11.1 2.3 0.58 10.2 2.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) SKA2 PF16740.5 ELR17584.1 - 0.34 10.7 10.2 1.2 8.9 2.5 2.8 2 1 1 3 3 3 0 Spindle and kinetochore-associated protein 2 TMPIT PF07851.13 ELR17584.1 - 0.4 9.9 1.0 0.69 9.1 1.0 1.3 1 0 0 1 1 1 0 TMPIT-like protein MGC-24 PF05283.11 ELR17584.1 - 1.2 9.6 8.4 0.63 10.5 3.1 2.3 2 0 0 2 2 2 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin Cnn_1N PF07989.11 ELR17584.1 - 1.2 9.3 5.4 3.6 7.8 1.5 2.9 2 1 1 3 3 3 0 Centrosomin N-terminal motif 1 bZIP_2 PF07716.15 ELR17584.1 - 1.3 9.1 12.5 0.55 10.3 1.3 2.5 1 1 1 2 2 2 0 Basic region leucine zipper DUF3450 PF11932.8 ELR17584.1 - 1.5 8.1 14.9 8.2 5.6 11.3 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) Mod_r PF07200.13 ELR17584.1 - 1.5 8.9 8.1 0.8 9.8 5.4 1.8 2 0 0 2 2 2 0 Modifier of rudimentary (Mod(r)) protein OmpH PF03938.14 ELR17584.1 - 2.9 8.2 10.5 1.3 9.4 7.1 1.9 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) ATG16 PF08614.11 ELR17584.1 - 4.1 7.6 19.5 0.16 12.1 10.0 2.4 2 1 1 3 3 3 0 Autophagy protein 16 (ATG16) TPR_MLP1_2 PF07926.12 ELR17584.1 - 4.5 7.3 11.2 0.3 11.2 5.0 1.9 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein DUF4407 PF14362.6 ELR17584.1 - 7.6 5.8 6.6 4.3 6.6 4.8 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) TPR_2 PF07719.17 ELR17585.1 - 7.4e-08 31.9 3.0 0.0092 16.0 0.3 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat FKBP_C PF00254.28 ELR17585.1 - 3.2e-07 30.6 0.0 6e-07 29.7 0.0 1.4 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase TPR_1 PF00515.28 ELR17585.1 - 9.3e-07 28.4 0.6 0.034 14.0 0.0 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat dsrm PF00035.26 ELR17585.1 - 2.2e-05 25.1 0.0 5.8e-05 23.7 0.0 1.8 1 0 0 1 1 1 1 Double-stranded RNA binding motif DND1_DSRM PF14709.7 ELR17585.1 - 0.00079 19.6 0.0 0.0019 18.4 0.0 1.7 1 0 0 1 1 1 1 double strand RNA binding domain from DEAD END PROTEIN 1 dsRBD2 PF17842.1 ELR17585.1 - 0.0046 17.2 0.5 0.045 14.0 0.3 2.2 1 1 1 2 2 2 1 Double-stranded RNA binding domain 2 TPR_14 PF13428.6 ELR17585.1 - 0.014 16.2 4.8 1.6 9.7 1.2 3.6 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_9 PF13371.6 ELR17585.1 - 0.02 15.0 1.8 0.02 15.0 1.8 2.1 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_12 PF13424.6 ELR17585.1 - 0.031 14.6 2.9 1.1 9.5 1.8 3.0 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_8 PF13181.6 ELR17585.1 - 0.049 13.9 0.0 27 5.3 0.0 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_7 PF13176.6 ELR17585.1 - 0.077 13.1 1.5 51 4.2 0.0 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat Dicer_dimer PF03368.14 ELR17585.1 - 0.14 12.4 0.1 1.2 9.3 0.0 2.2 2 0 0 2 2 2 0 Dicer dimerisation domain TPR_16 PF13432.6 ELR17585.1 - 0.14 12.8 6.6 0.75 10.5 2.1 2.9 2 1 1 3 3 3 0 Tetratricopeptide repeat BTAD PF03704.17 ELR17585.1 - 0.67 10.4 5.8 5.6 7.4 0.2 2.4 1 1 1 2 2 2 0 Bacterial transcriptional activator domain U-box PF04564.15 ELR17586.1 - 1e-20 73.7 0.0 4e-20 71.8 0.0 2.0 2 0 0 2 2 2 1 U-box domain zf-Nse PF11789.8 ELR17586.1 - 0.00012 21.8 0.0 0.00026 20.8 0.0 1.5 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit DMA PF03474.14 ELR17586.1 - 0.00052 19.6 0.0 0.0024 17.4 0.1 2.0 2 0 0 2 2 2 1 DMRTA motif Cast PF10174.9 ELR17586.1 - 0.013 13.8 0.2 0.02 13.1 0.2 1.2 1 0 0 1 1 1 0 RIM-binding protein of the cytomatrix active zone zf-NOSIP PF15906.5 ELR17586.1 - 0.013 15.6 0.0 0.027 14.6 0.0 1.5 1 0 0 1 1 1 0 Zinc-finger of nitric oxide synthase-interacting protein CUE PF02845.16 ELR17586.1 - 0.015 15.0 0.1 0.051 13.3 0.1 2.0 1 0 0 1 1 1 0 CUE domain zf-RING_UBOX PF13445.6 ELR17586.1 - 0.04 14.0 0.0 0.078 13.0 0.0 1.5 1 0 0 1 1 1 0 RING-type zinc-finger Met_synt_B12 PF02965.17 ELR17587.1 - 8.8e-117 389.4 0.3 1.4e-116 388.8 0.3 1.3 1 0 0 1 1 1 1 Vitamin B12 dependent methionine synthase, activation domain S-methyl_trans PF02574.16 ELR17587.1 - 1e-61 209.1 0.0 4.1e-59 200.6 0.0 2.5 1 1 0 1 1 1 1 Homocysteine S-methyltransferase Pterin_bind PF00809.22 ELR17587.1 - 6.6e-58 196.3 0.2 5.3e-57 193.3 0.2 2.2 2 0 0 2 2 2 1 Pterin binding enzyme B12-binding_2 PF02607.17 ELR17587.1 - 6.7e-25 87.3 0.0 2.5e-24 85.5 0.0 2.1 1 0 0 1 1 1 1 B12 binding domain B12-binding PF02310.19 ELR17587.1 - 6.4e-19 68.2 0.7 5.3e-18 65.2 0.3 2.8 3 0 0 3 3 3 1 B12 binding domain NFRKB_winged PF14465.6 ELR17587.1 - 0.098 12.9 0.0 0.32 11.2 0.0 1.8 1 0 0 1 1 1 0 NFRKB Winged Helix-like zf-C2H2 PF00096.26 ELR17588.1 - 1e-05 25.7 19.0 0.014 15.8 3.7 5.1 4 0 0 4 4 4 3 Zinc finger, C2H2 type zf-C2HE PF16278.5 ELR17588.1 - 0.0012 19.3 0.0 0.0012 19.3 0.0 3.2 2 1 0 2 2 2 1 C2HE / C2H2 / C2HC zinc-binding finger zf-C2H2_4 PF13894.6 ELR17588.1 - 0.027 15.3 31.1 0.071 14.0 3.0 6.3 6 1 0 6 6 6 0 C2H2-type zinc finger Beta_helix PF13229.6 ELR17589.1 - 7.3e-16 58.4 14.8 6.2e-09 35.9 0.4 3.3 1 1 2 3 3 3 3 Right handed beta helix region BA14K PF07886.11 ELR17590.1 - 0.5 10.3 4.3 1.2 9.1 4.3 1.5 1 0 0 1 1 1 0 BA14K-like protein DUF3367 PF11847.8 ELR17590.1 - 0.97 7.2 3.9 1.4 6.7 3.9 1.1 1 0 0 1 1 1 0 Alpha-(1->3)-arabinofuranosyltransferase MerC PF03203.14 ELR17590.1 - 2.5 8.6 12.4 5.4 7.5 12.5 1.5 1 1 0 1 1 1 0 MerC mercury resistance protein dCMP_cyt_deam_1 PF00383.23 ELR17591.1 - 7.4e-12 45.0 0.0 9.5e-12 44.7 0.0 1.2 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 ELR17591.1 - 3.6e-05 23.5 1.2 0.00017 21.3 1.2 1.8 1 1 0 1 1 1 1 MafB19-like deaminase TNFR_16_TM PF18422.1 ELR17592.1 - 1.3 9.1 4.1 3.2 7.8 4.1 1.7 1 0 0 1 1 1 0 Tumor necrosis factor receptor member 16 trans-membrane domain Tetraspanin PF00335.20 ELR17592.1 - 6.1 6.5 13.9 3.3 7.3 11.6 1.7 1 1 0 1 1 1 0 Tetraspanin family Neurensin PF14927.6 ELR17594.1 - 0.016 14.9 0.0 0.016 14.9 0.0 2.4 1 1 1 2 2 2 0 Neurensin SelK_SelG PF10961.8 ELR17594.1 - 0.18 12.4 0.1 0.32 11.6 0.1 1.5 1 0 0 1 1 1 0 Selenoprotein SelK_SelG Herpes_LMP1 PF05297.11 ELR17594.1 - 0.32 10.2 3.8 0.36 10.0 3.8 1.3 1 0 0 1 1 1 0 Herpesvirus latent membrane protein 1 (LMP1) RasGEF PF00617.19 ELR17595.1 - 2.4e-50 171.2 0.3 4.1e-50 170.4 0.3 1.4 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 ELR17595.1 - 1.6e-22 79.7 0.1 1.6e-22 79.7 0.1 2.1 3 0 0 3 3 3 1 RasGEF N-terminal motif GAS PF13851.6 ELR17595.1 - 0.00081 18.8 1.3 0.0018 17.7 1.3 1.5 1 0 0 1 1 1 1 Growth-arrest specific micro-tubule binding Cnn_1N PF07989.11 ELR17595.1 - 0.0034 17.5 0.2 0.01 16.0 0.2 1.7 1 0 0 1 1 1 1 Centrosomin N-terminal motif 1 FlaC_arch PF05377.11 ELR17595.1 - 0.04 14.3 0.1 0.085 13.3 0.1 1.5 1 0 0 1 1 1 0 Flagella accessory protein C (FlaC) TSC22 PF01166.18 ELR17595.1 - 0.14 12.5 0.3 0.38 11.1 0.3 1.7 1 0 0 1 1 1 0 TSC-22/dip/bun family DivIC PF04977.15 ELR17595.1 - 0.24 11.2 1.0 0.63 9.9 1.0 1.7 1 0 0 1 1 1 0 Septum formation initiator Seryl_tRNA_N PF02403.22 ELR17595.1 - 0.59 10.4 3.0 7.6 6.8 0.6 2.6 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain Nop25 PF09805.9 ELR17595.1 - 1.7 9.1 6.5 10 6.6 1.2 2.7 2 0 0 2 2 2 0 Nucleolar protein 12 (25kDa) Uds1 PF15456.6 ELR17595.1 - 6.3 7.0 6.5 0.93 9.7 1.6 2.1 2 0 0 2 2 2 0 Up-regulated During Septation ZapB PF06005.12 ELR17595.1 - 8.8 6.9 6.6 1.1 9.7 1.0 2.3 2 0 0 2 2 2 0 Cell division protein ZapB zf-CCHC PF00098.23 ELR17596.1 - 2.3e-09 36.9 8.9 3.8e-05 23.6 2.4 2.4 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_4 PF14392.6 ELR17596.1 - 0.0018 18.0 5.4 0.5 10.1 0.4 2.3 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_5 PF14787.6 ELR17596.1 - 0.018 14.8 7.0 0.31 10.8 0.9 2.6 1 1 1 2 2 2 0 GAG-polyprotein viral zinc-finger Zn_ribbon_2 PF12674.7 ELR17596.1 - 0.089 13.5 0.5 0.089 13.5 0.5 2.5 2 1 0 2 2 2 0 Putative zinc ribbon domain zf-CCHC_2 PF13696.6 ELR17596.1 - 0.15 12.0 9.4 0.063 13.1 2.7 2.3 2 0 0 2 2 2 0 Zinc knuckle Vps55 PF04133.14 ELR17597.1 - 5.7e-28 97.2 2.5 6e-27 93.9 2.5 1.9 1 1 0 1 1 1 1 Vacuolar protein sorting 55 CW_binding_2 PF04122.12 ELR17597.1 - 0.14 12.9 0.0 0.18 12.5 0.0 1.2 1 0 0 1 1 1 0 Putative cell wall binding repeat 2 adh_short PF00106.25 ELR17598.1 - 2.6e-38 131.5 3.4 2.6e-38 131.5 3.4 2.0 2 0 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.6 ELR17598.1 - 3.9e-32 111.7 1.1 7.7e-32 110.7 1.1 1.5 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase MaoC_dehydratas PF01575.19 ELR17598.1 - 9.5e-31 105.9 0.0 2.4e-30 104.6 0.0 1.7 2 0 0 2 2 2 1 MaoC like domain SCP2 PF02036.17 ELR17598.1 - 1e-22 80.5 0.1 2.4e-22 79.3 0.1 1.7 1 0 0 1 1 1 1 SCP-2 sterol transfer family MaoC_dehydrat_N PF13452.6 ELR17598.1 - 1.6e-15 57.4 0.0 1.7e-11 44.4 0.0 2.5 2 0 0 2 2 2 2 N-terminal half of MaoC dehydratase KR PF08659.10 ELR17598.1 - 3.4e-14 53.1 1.6 3.4e-14 53.1 1.6 2.2 2 0 0 2 2 2 1 KR domain THF_DHG_CYH_C PF02882.19 ELR17598.1 - 0.00019 20.8 0.7 0.00042 19.7 0.7 1.5 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Alkyl_sulf_C PF14864.6 ELR17598.1 - 0.0012 19.1 0.1 0.0024 18.1 0.1 1.6 1 0 0 1 1 1 1 Alkyl sulfatase C-terminal CHRD PF07452.12 ELR17598.1 - 0.0083 17.1 0.4 0.031 15.2 0.4 2.0 1 0 0 1 1 1 1 CHRD domain CBM_35 PF16990.5 ELR17598.1 - 0.011 16.0 0.1 0.069 13.4 0.0 2.4 2 1 0 2 2 2 0 Carbohydrate binding module (family 35) 3HCDH_N PF02737.18 ELR17598.1 - 0.17 11.7 1.7 0.37 10.7 1.7 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Ribosomal_60s PF00428.19 ELR17598.1 - 1.2 9.8 8.9 5.2 7.7 4.7 2.7 2 0 0 2 2 2 0 60s Acidic ribosomal protein Rep_fac-A_3 PF08661.11 ELR17599.1 - 9.8e-18 64.4 0.0 1.3e-17 64.1 0.0 1.0 1 0 0 1 1 1 1 Replication factor A protein 3 DUF3987 PF13148.6 ELR17599.1 - 0.2 10.6 0.0 0.22 10.5 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3987) CBFD_NFYB_HMF PF00808.23 ELR17600.1 - 1.5e-22 79.6 1.1 3e-22 78.7 1.1 1.5 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 ELR17600.1 - 2.9e-15 56.8 2.0 2.9e-15 56.8 2.0 1.8 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 CENP-X PF09415.10 ELR17600.1 - 0.014 15.6 0.1 0.039 14.3 0.1 1.7 1 0 0 1 1 1 0 CENP-S associating Centromere protein X F-box-like PF12937.7 ELR17602.1 - 7.8e-14 51.3 0.2 1.8e-13 50.2 0.2 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ELR17602.1 - 2.1e-09 37.1 0.0 4e-09 36.1 0.0 1.4 1 0 0 1 1 1 1 F-box domain F-box_4 PF15966.5 ELR17602.1 - 0.0016 18.3 0.0 0.016 15.1 0.0 2.2 2 0 0 2 2 2 1 F-box Taxilin PF09728.9 ELR17602.1 - 0.71 9.0 12.0 0.18 10.9 7.7 1.9 2 0 0 2 2 2 0 Myosin-like coiled-coil protein Mito_carr PF00153.27 ELR17603.1 - 2.7e-54 181.1 5.5 2.6e-18 65.7 0.1 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein RVT_1 PF00078.27 ELR17604.1 - 6.1e-33 114.2 0.0 9.4e-33 113.6 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-C2H2_4 PF13894.6 ELR17604.1 - 0.00021 21.8 20.8 0.065 14.1 3.6 4.2 4 0 0 4 4 4 3 C2H2-type zinc finger zf-Di19 PF05605.12 ELR17604.1 - 0.00053 20.2 11.9 1 9.7 0.1 3.8 3 0 0 3 3 3 3 Drought induced 19 protein (Di19), zinc-binding zf-C2H2 PF00096.26 ELR17604.1 - 0.01 16.2 17.7 0.031 14.7 3.5 3.7 3 0 0 3 3 3 0 Zinc finger, C2H2 type zf-C2H2_11 PF16622.5 ELR17604.1 - 0.025 14.3 5.5 0.38 10.6 0.2 2.7 2 0 0 2 2 2 0 zinc-finger C2H2-type zf-RVT PF13966.6 ELR17604.1 - 0.053 14.2 2.2 0.085 13.6 0.2 2.5 2 0 0 2 2 2 0 zinc-binding in reverse transcriptase Rad50_zn_hook PF04423.14 ELR17604.1 - 0.14 12.0 0.4 1.6 8.6 0.1 2.4 2 0 0 2 2 2 0 Rad50 zinc hook motif zinc_ribbon_9 PF14369.6 ELR17604.1 - 0.3 11.4 4.2 5.6 7.3 0.3 3.0 2 0 0 2 2 2 0 zinc-ribbon zf-C2H2_jaz PF12171.8 ELR17604.1 - 1.5 9.2 3.5 7.1 7.0 0.1 2.9 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding Amidase PF01425.21 ELR17605.1 - 1.5e-102 343.9 0.0 2.7e-102 343.1 0.0 1.4 1 1 0 1 1 1 1 Amidase Snf7 PF03357.21 ELR17606.1 - 2.5e-48 164.0 15.1 2.5e-48 164.0 15.1 1.4 2 0 0 2 2 2 1 Snf7 DUF2840 PF11000.8 ELR17606.1 - 0.017 14.9 0.0 0.024 14.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2840) PIN_8 PF18476.1 ELR17606.1 - 0.019 14.8 2.7 0.054 13.3 2.8 1.7 1 1 0 1 1 1 0 PIN like domain DUF2586 PF10758.9 ELR17606.1 - 0.31 10.2 3.7 0.39 9.8 3.7 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF2586) Cyt-b5 PF00173.28 ELR17607.1 - 1.5e-12 47.4 0.0 1.8e-12 47.2 0.0 1.2 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain AMP-binding PF00501.28 ELR17608.1 - 6.5e-76 255.6 0.0 1.2e-75 254.8 0.0 1.4 1 0 0 1 1 1 1 AMP-binding enzyme NAD_binding_4 PF07993.12 ELR17608.1 - 2.3e-62 210.5 0.0 3.7e-62 209.8 0.0 1.3 1 0 0 1 1 1 1 Male sterility protein Condensation PF00668.20 ELR17608.1 - 1.4e-23 83.3 0.0 2.6e-23 82.4 0.0 1.3 1 0 0 1 1 1 1 Condensation domain AlaDh_PNT_N PF05222.15 ELR17608.1 - 4.3e-17 62.7 0.0 9.5e-17 61.6 0.0 1.5 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, N-terminal domain PP-binding PF00550.25 ELR17608.1 - 2.5e-14 53.4 0.1 8.7e-14 51.6 0.1 2.1 1 0 0 1 1 1 1 Phosphopantetheine attachment site Epimerase PF01370.21 ELR17608.1 - 6.4e-12 45.4 0.0 5.4e-11 42.4 0.0 2.2 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family AMP-binding_C PF13193.6 ELR17608.1 - 1.8e-10 41.6 0.1 1.3e-09 38.9 0.1 2.7 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain GDP_Man_Dehyd PF16363.5 ELR17608.1 - 9e-05 22.0 0.0 0.00014 21.4 0.0 1.3 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase 3Beta_HSD PF01073.19 ELR17608.1 - 0.00015 20.9 0.0 0.0027 16.8 0.0 2.4 2 1 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family DUF2092 PF09865.9 ELR17608.1 - 0.017 14.5 0.1 0.042 13.2 0.1 1.6 1 0 0 1 1 1 0 Predicted periplasmic protein (DUF2092) Polysacc_synt_2 PF02719.15 ELR17608.1 - 0.23 10.5 0.0 0.39 9.8 0.0 1.3 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein TPR_1 PF00515.28 ELR17609.1 - 2.1e-42 141.3 19.8 3.2e-07 29.9 0.0 11.0 11 0 0 11 11 11 9 Tetratricopeptide repeat TPR_2 PF07719.17 ELR17609.1 - 2.3e-36 121.0 25.3 0.00018 21.4 0.7 11.3 10 1 1 11 11 11 9 Tetratricopeptide repeat TPR_8 PF13181.6 ELR17609.1 - 2.7e-27 92.7 5.8 0.0013 18.8 0.6 10.9 10 1 1 11 11 11 5 Tetratricopeptide repeat TPR_16 PF13432.6 ELR17609.1 - 1.1e-25 90.0 34.1 1.4e-07 32.0 1.4 8.3 4 3 3 7 7 7 6 Tetratricopeptide repeat TPR_11 PF13414.6 ELR17609.1 - 2e-23 81.8 15.5 9.3e-06 25.2 0.1 9.0 5 3 3 9 9 9 5 TPR repeat TPR_9 PF13371.6 ELR17609.1 - 1.5e-20 73.1 23.0 0.0016 18.6 0.0 7.6 4 2 3 7 7 7 6 Tetratricopeptide repeat TPR_17 PF13431.6 ELR17609.1 - 4.5e-16 58.0 7.0 0.004 17.4 0.1 8.4 8 0 0 8 8 7 3 Tetratricopeptide repeat TPR_12 PF13424.6 ELR17609.1 - 1.5e-14 54.0 23.4 2.4e-05 24.5 0.4 7.5 3 3 3 6 6 6 4 Tetratricopeptide repeat TPR_14 PF13428.6 ELR17609.1 - 1.1e-13 50.7 35.4 0.052 14.4 0.5 11.6 4 3 8 12 12 12 5 Tetratricopeptide repeat TPR_19 PF14559.6 ELR17609.1 - 4.3e-11 43.2 23.4 0.0024 18.4 0.0 7.0 5 2 2 7 7 7 2 Tetratricopeptide repeat TPR_7 PF13176.6 ELR17609.1 - 7.7e-09 35.0 10.7 4.8 7.4 0.3 8.9 8 2 2 10 10 10 2 Tetratricopeptide repeat TPR_6 PF13174.6 ELR17609.1 - 2.7e-08 33.9 15.5 0.33 11.7 0.0 9.8 10 1 1 11 11 10 1 Tetratricopeptide repeat ANAPC3 PF12895.7 ELR17609.1 - 6.1e-07 29.6 7.6 0.0012 19.0 0.3 4.8 4 1 0 4 4 4 1 Anaphase-promoting complex, cyclosome, subunit 3 NARP1 PF12569.8 ELR17609.1 - 0.0007 18.6 0.0 3.2 6.6 0.0 3.3 2 1 0 3 3 3 1 NMDA receptor-regulated protein 1 TPR_10 PF13374.6 ELR17609.1 - 0.0035 17.1 15.6 6.1 6.9 0.3 7.6 8 1 1 9 9 8 1 Tetratricopeptide repeat AvrB_AvrC PF05394.11 ELR17609.1 - 0.12 11.6 0.0 0.19 10.9 0.0 1.2 1 0 0 1 1 1 0 Avirulence protein EST1_DNA_bind PF10373.9 ELR17609.1 - 0.15 11.5 0.0 0.24 10.8 0.0 1.2 1 0 0 1 1 1 0 Est1 DNA/RNA binding domain BTAD PF03704.17 ELR17609.1 - 0.42 11.0 14.5 3.4 8.1 0.7 4.5 2 1 1 4 4 4 0 Bacterial transcriptional activator domain Fis1_TPR_C PF14853.6 ELR17609.1 - 0.77 9.9 6.1 4.2 7.5 0.3 4.3 5 0 0 5 5 4 0 Fis1 C-terminal tetratricopeptide repeat Med3 PF11593.8 ELR17609.1 - 6 5.9 17.9 9.2 5.3 17.9 1.1 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal Solute_trans_a PF03619.16 ELR17610.1 - 3.6e-89 298.8 8.5 4.7e-89 298.4 8.5 1.1 1 0 0 1 1 1 1 Organic solute transporter Ostalpha BaxI_1 PF12811.7 ELR17610.1 - 0.0052 16.4 3.1 0.57 9.7 0.6 2.3 2 0 0 2 2 2 2 Bax inhibitor 1 like TauD PF02668.16 ELR17611.1 - 1.4e-40 139.8 0.3 1.9e-40 139.4 0.3 1.1 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family CsiD PF08943.10 ELR17611.1 - 0.0018 17.4 0.0 0.0029 16.8 0.0 1.6 1 1 0 1 1 1 1 CsiD PH PF00169.29 ELR17612.1 - 1.5e-19 70.4 0.0 2e-19 70.0 0.0 1.1 1 0 0 1 1 1 1 PH domain PH_11 PF15413.6 ELR17612.1 - 8.4e-06 26.2 0.7 0.00016 22.1 0.7 2.2 1 1 0 1 1 1 1 Pleckstrin homology domain PH_6 PF15406.6 ELR17612.1 - 0.0012 19.1 0.0 0.0025 18.1 0.0 1.5 1 0 0 1 1 1 1 Pleckstrin homology domain PH_9 PF15410.6 ELR17612.1 - 0.013 15.9 0.0 0.03 14.7 0.0 1.7 1 1 0 1 1 1 0 Pleckstrin homology domain PH_13 PF16652.5 ELR17612.1 - 0.016 15.0 0.0 0.034 14.0 0.0 1.5 1 1 0 1 1 1 0 Pleckstrin homology domain PH_3 PF14593.6 ELR17612.1 - 0.018 15.1 0.0 0.28 11.3 0.0 2.3 1 1 1 2 2 2 0 PH domain PAC2 PF09754.9 ELR17612.1 - 0.14 12.2 0.0 0.17 11.9 0.0 1.3 1 0 0 1 1 1 0 PAC2 family PAP_assoc PF03828.19 ELR17614.1 - 3.3e-12 46.4 0.2 7.1e-12 45.4 0.2 1.6 1 0 0 1 1 1 1 Cid1 family poly A polymerase NTP_transf_2 PF01909.23 ELR17614.1 - 7.6e-10 39.0 0.0 1.5e-09 38.0 0.0 1.4 1 0 0 1 1 1 1 Nucleotidyltransferase domain Polbeta PF18765.1 ELR17614.1 - 0.0072 16.4 0.0 0.014 15.4 0.0 1.4 1 0 0 1 1 1 1 Polymerase beta, Nucleotidyltransferase HRCT1 PF15758.5 ELR17614.1 - 2.6 9.1 11.1 1.3 10.1 0.3 3.7 4 0 0 4 4 4 0 Histidine-rich carboxyl terminus protein 1 SPRY PF00622.28 ELR17616.1 - 2.5e-19 69.6 0.0 5.2e-19 68.5 0.0 1.5 1 0 0 1 1 1 1 SPRY domain BACK PF07707.15 ELR17616.1 - 0.0072 16.4 0.0 0.8 9.8 0.0 2.4 2 0 0 2 2 2 1 BTB And C-terminal Kelch Neuralized PF07177.12 ELR17616.1 - 0.014 15.5 0.0 0.18 11.8 0.0 2.2 1 1 0 1 1 1 0 Neuralized DUF2868 PF11067.8 ELR17616.1 - 7.5 6.0 10.4 14 5.0 10.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2868) DHHC PF01529.20 ELR17617.1 - 0.00025 21.1 3.5 0.00025 21.1 3.5 2.5 2 1 1 3 3 3 2 DHHC palmitoyltransferase YrhK PF14145.6 ELR17617.1 - 0.15 12.0 0.3 0.15 12.0 0.3 2.1 2 1 0 2 2 2 0 YrhK-like protein Caa3_CtaG PF09678.10 ELR17617.1 - 0.55 9.7 10.9 0.22 10.9 3.2 2.2 2 0 0 2 2 2 0 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG) VASt PF16016.5 ELR17618.1 - 1.2e-21 77.7 0.0 1.9e-21 77.1 0.0 1.3 1 0 0 1 1 1 1 VAD1 Analog of StAR-related lipid transfer domain GRAM PF02893.20 ELR17618.1 - 0.00021 21.1 0.0 0.00038 20.3 0.0 1.4 1 0 0 1 1 1 1 GRAM domain DUF3275 PF11679.8 ELR17618.1 - 2.5 8.0 4.2 20 5.1 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3275) CDC45 PF02724.14 ELR17619.1 - 0.71 8.1 7.2 0.96 7.7 7.2 1.2 1 0 0 1 1 1 0 CDC45-like protein GtrA PF04138.14 ELR17621.1 - 1.4e-08 35.0 8.4 1.8e-08 34.6 8.4 1.1 1 0 0 1 1 1 1 GtrA-like protein PrgI PF12666.7 ELR17621.1 - 0.076 13.7 0.7 30 5.4 2.2 2.4 2 1 0 2 2 2 0 PrgI family protein GATA PF00320.27 ELR17622.1 - 0.085 12.5 3.7 0.19 11.3 3.7 1.5 1 0 0 1 1 1 0 GATA zinc finger Metallophos PF00149.28 ELR17623.1 - 1.4e-08 35.5 0.0 3.6e-08 34.2 0.0 1.7 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 ELR17623.1 - 3.3e-06 27.4 0.3 0.026 14.7 0.1 2.2 2 0 0 2 2 2 2 Calcineurin-like phosphoesterase superfamily domain DUF4611 PF15387.6 ELR17623.1 - 0.027 14.7 8.4 0.49 10.6 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4611) GEN1_C PF18380.1 ELR17623.1 - 1.1 10.1 7.2 6.3 7.7 4.4 2.4 2 0 0 2 2 2 0 Holliday junction resolvase Gen1 C-terminal domain TLP-20 PF06088.11 ELR17623.1 - 1.6 8.6 5.3 1.9 8.3 1.3 2.1 2 0 0 2 2 2 0 Nucleopolyhedrovirus telokin-like protein-20 (TLP20) CDC45 PF02724.14 ELR17623.1 - 2.8 6.1 6.7 4.6 5.4 4.3 1.9 2 0 0 2 2 2 0 CDC45-like protein RCC1 PF00415.18 ELR17624.1 - 9.3e-57 189.5 26.8 1.7e-14 54.2 0.1 8.4 8 1 1 9 9 9 6 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 ELR17624.1 - 1.1e-29 101.5 26.5 4e-06 26.5 1.5 7.4 7 0 0 7 7 7 5 Regulator of chromosome condensation (RCC1) repeat PapC_C PF13953.6 ELR17624.1 - 0.03 14.1 0.9 7 6.6 0.1 2.8 2 0 0 2 2 2 0 PapC C-terminal domain DUF1459 PF07312.11 ELR17624.1 - 0.32 11.3 6.5 17 5.7 0.0 3.9 5 0 0 5 5 5 0 Protein of unknown function (DUF1459) DAO PF01266.24 ELR17625.1 - 2.8e-31 109.4 0.0 3.2e-31 109.2 0.0 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 ELR17625.1 - 0.022 14.0 0.0 0.037 13.3 0.0 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 ELR17625.1 - 0.11 11.7 0.2 3.4 6.8 0.0 2.1 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase AAA_23 PF13476.6 ELR17626.1 - 6.4e-35 121.5 8.7 6.4e-35 121.5 8.7 8.6 1 1 3 4 4 1 1 AAA domain AAA_15 PF13175.6 ELR17626.1 - 1.1e-10 41.8 0.1 1.1e-10 41.8 0.1 5.5 1 1 1 3 3 1 1 AAA ATPase domain AAA_21 PF13304.6 ELR17626.1 - 1.8e-09 37.9 0.2 0.0033 17.3 0.1 3.2 2 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SbcCD_C PF13558.6 ELR17626.1 - 0.00017 21.8 0.0 0.00051 20.2 0.0 1.9 1 0 0 1 1 1 1 Putative exonuclease SbcCD, C subunit Rad50_zn_hook PF04423.14 ELR17626.1 - 0.00031 20.5 0.0 0.00031 20.5 0.0 6.4 6 0 0 6 6 5 1 Rad50 zinc hook motif AAA_29 PF13555.6 ELR17626.1 - 0.0037 17.0 0.0 0.009 15.7 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain ABC_tran PF00005.27 ELR17626.1 - 0.0075 16.8 0.0 0.0075 16.8 0.0 7.6 4 2 1 5 5 3 1 ABC transporter AAA_13 PF13166.6 ELR17626.1 - 0.024 13.3 0.0 0.024 13.3 0.0 7.0 3 1 2 6 6 4 0 AAA domain AAA_25 PF13481.6 ELR17626.1 - 0.065 12.8 0.0 12 5.5 0.0 3.1 2 0 0 2 2 2 0 AAA domain GTP_EFTU PF00009.27 ELR17626.1 - 0.17 11.4 0.0 0.17 11.4 0.0 3.4 4 0 0 4 4 4 0 Elongation factor Tu GTP binding domain AAA_22 PF13401.6 ELR17626.1 - 0.55 10.5 0.0 0.55 10.5 0.0 5.5 5 1 1 6 6 6 0 AAA domain AAA_27 PF13514.6 ELR17626.1 - 0.67 9.5 0.0 0.67 9.5 0.0 7.7 5 4 3 9 9 9 0 AAA domain THOC7 PF05615.13 ELR17627.1 - 4.3e-23 82.0 9.2 4.3e-23 82.0 9.2 2.4 1 1 1 2 2 2 1 Tho complex subunit 7 Baculo_PP31 PF05311.11 ELR17627.1 - 0.0086 15.6 3.2 0.92 8.9 0.0 2.4 2 1 0 2 2 2 2 Baculovirus 33KDa late protein (PP31) tRNA-synt_1g PF09334.11 ELR17627.1 - 0.059 12.1 0.9 0.08 11.7 0.9 1.2 1 0 0 1 1 1 0 tRNA synthetases class I (M) AAA_13 PF13166.6 ELR17627.1 - 0.41 9.2 11.1 0.58 8.7 11.1 1.2 1 0 0 1 1 1 0 AAA domain LMBR1 PF04791.16 ELR17627.1 - 0.49 9.2 5.0 0.55 9.1 5.0 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein FlxA PF14282.6 ELR17627.1 - 2.1 8.4 14.1 0.16 12.0 4.2 2.6 1 1 0 2 2 2 0 FlxA-like protein CorA PF01544.18 ELR17627.1 - 3.4 6.9 11.5 4.1 6.6 10.3 1.6 1 1 1 2 2 2 0 CorA-like Mg2+ transporter protein AATF-Che1 PF13339.6 ELR17627.1 - 8.9 7.0 11.7 0.8 10.4 4.2 2.3 1 1 1 2 2 2 0 Apoptosis antagonizing transcription factor Ceramidase PF05875.12 ELR17628.1 - 2.4e-35 122.3 0.5 3.4e-35 121.7 0.5 1.2 1 0 0 1 1 1 1 Ceramidase Doppel PF11466.8 ELR17628.1 - 0.21 11.3 3.3 7.2 6.4 0.3 2.8 2 0 0 2 2 2 0 Prion-like protein Doppel THUMP PF02926.17 ELR17629.1 - 2.4e-08 34.2 0.6 5.5e-08 33.0 0.0 1.9 3 0 0 3 3 3 1 THUMP domain RRM_1 PF00076.22 ELR17630.1 - 2.6e-17 62.4 1.6 5.3e-17 61.4 0.1 2.1 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Cas_Cas2CT1978 PF09707.10 ELR17630.1 - 0.039 14.0 0.1 4.3 7.5 0.1 2.3 1 1 1 2 2 2 0 CRISPR-associated protein (Cas_Cas2CT1978) F-box-like PF12937.7 ELR17631.1 - 1.8e-06 27.7 0.1 4.4e-06 26.5 0.1 1.7 1 0 0 1 1 1 1 F-box-like WD40 PF00400.32 ELR17631.1 - 3e-06 27.9 4.5 0.029 15.2 0.6 4.1 3 0 0 3 3 3 1 WD domain, G-beta repeat F-box PF00646.33 ELR17631.1 - 1.8e-05 24.5 0.0 4.6e-05 23.2 0.0 1.7 1 0 0 1 1 1 1 F-box domain Tim54 PF11711.8 ELR17631.1 - 0.022 13.5 1.5 0.032 13.0 1.5 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 CDC45 PF02724.14 ELR17631.1 - 0.16 10.2 3.5 0.22 9.8 3.5 1.1 1 0 0 1 1 1 0 CDC45-like protein CobT PF06213.12 ELR17631.1 - 0.2 11.0 13.0 0.34 10.3 13.0 1.3 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Pox_Ag35 PF03286.14 ELR17631.1 - 0.44 10.3 5.2 0.74 9.6 5.2 1.3 1 0 0 1 1 1 0 Pox virus Ag35 surface protein RNA_pol_Rpc4 PF05132.14 ELR17631.1 - 0.64 10.4 2.6 1.1 9.7 2.6 1.3 1 0 0 1 1 1 0 RNA polymerase III RPC4 DNA_pol_phi PF04931.13 ELR17631.1 - 1.8 6.6 14.3 2.4 6.1 14.3 1.1 1 0 0 1 1 1 0 DNA polymerase phi Nop14 PF04147.12 ELR17631.1 - 1.8 6.7 11.3 2.5 6.2 11.3 1.1 1 0 0 1 1 1 0 Nop14-like family PSK PF06404.12 ELR17631.1 - 2.5 9.2 6.7 5.7 8.0 6.7 1.5 1 0 0 1 1 1 0 Phytosulfokine precursor protein (PSK) FAM176 PF14851.6 ELR17631.1 - 3.3 7.4 8.7 5.9 6.5 8.7 1.4 1 0 0 1 1 1 0 FAM176 family TRAP_alpha PF03896.16 ELR17631.1 - 5 6.2 6.5 8.6 5.5 6.5 1.3 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit SDA1 PF05285.12 ELR17631.1 - 7.1 6.0 13.2 10 5.4 13.2 1.1 1 0 0 1 1 1 0 SDA1 CAP_N PF01213.19 ELR17632.1 - 0.4 10.1 2.4 0.54 9.7 2.4 1.3 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal SH3_9 PF14604.6 ELR17633.1 - 8.5e-44 147.2 0.6 1.7e-14 53.4 0.0 3.2 3 0 0 3 3 3 3 Variant SH3 domain SH3_1 PF00018.28 ELR17633.1 - 1.8e-43 145.9 0.5 7.2e-14 51.1 0.0 3.2 3 0 0 3 3 3 3 SH3 domain SH3_2 PF07653.17 ELR17633.1 - 7.4e-31 105.6 0.2 9.5e-11 41.2 0.0 3.2 3 0 0 3 3 3 3 Variant SH3 domain WH2 PF02205.20 ELR17633.1 - 2.2e-18 65.4 4.4 1.4e-08 34.2 0.5 2.7 2 0 0 2 2 2 2 WH2 motif Thymosin PF01290.20 ELR17633.1 - 0.0016 18.1 0.0 2.3 8.0 0.0 2.3 2 0 0 2 2 2 2 Thymosin beta-4 family TSP9 PF11493.8 ELR17633.1 - 6.4 7.5 10.3 15 6.4 0.8 2.9 2 1 0 2 2 2 0 Thylakoid soluble phosphoprotein TSP9 PC4 PF02229.16 ELR17634.1 - 2.2e-24 84.8 1.0 3.5e-24 84.2 1.0 1.3 1 0 0 1 1 1 1 Transcriptional Coactivator p15 (PC4) Glyco_transf_8 PF01501.20 ELR17635.1 - 0.006 16.2 0.6 0.012 15.1 0.2 1.7 2 0 0 2 2 2 1 Glycosyl transferase family 8 PH PF00169.29 ELR17636.1 - 1.9e-10 41.2 0.0 3e-10 40.5 0.0 1.3 1 0 0 1 1 1 1 PH domain EF-hand_7 PF13499.6 ELR17636.1 - 1.6e-07 31.7 1.7 0.017 15.6 0.0 3.4 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_1 PF00036.32 ELR17636.1 - 6.4e-06 25.3 2.3 0.031 13.8 0.1 3.3 3 0 0 3 3 3 2 EF hand EF-hand_8 PF13833.6 ELR17636.1 - 9.9e-05 22.1 0.5 0.36 10.7 0.1 3.1 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 ELR17636.1 - 0.00025 20.7 0.4 0.16 11.9 0.0 3.8 3 0 0 3 3 3 1 EF-hand domain DUF3395 PF11875.8 ELR17636.1 - 0.0036 17.2 0.0 0.0069 16.3 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3395) EF-hand_5 PF13202.6 ELR17636.1 - 2 8.0 5.2 1.4 8.6 0.1 3.0 3 0 0 3 3 3 0 EF hand PLDc PF00614.22 ELR17637.1 - 2.8e-21 74.8 1.8 1.1e-10 41.3 0.1 2.6 2 0 0 2 2 2 2 Phospholipase D Active site motif PLDc_2 PF13091.6 ELR17637.1 - 4.6e-15 55.7 0.2 2.4e-11 43.7 0.0 2.6 2 1 0 2 2 2 2 PLD-like domain Eaf7 PF07904.13 ELR17638.1 - 3.1e-07 30.7 0.0 3.1e-07 30.7 0.0 3.0 2 2 0 2 2 2 1 Chromatin modification-related protein EAF7 Forkhead PF00250.18 ELR17638.1 - 7.9e-05 22.8 0.2 0.00016 21.8 0.2 1.5 1 0 0 1 1 1 1 Forkhead domain TEA PF01285.18 ELR17638.1 - 0.019 15.1 0.0 0.041 14.0 0.0 1.5 1 0 0 1 1 1 0 TEA/ATTS domain BUD22 PF09073.10 ELR17638.1 - 0.041 13.2 28.1 0.059 12.7 28.1 1.2 1 0 0 1 1 1 0 BUD22 Aldedh PF00171.22 ELR17639.1 - 9.6e-109 363.9 0.9 2.3e-95 319.8 0.1 2.3 1 1 1 2 2 2 2 Aldehyde dehydrogenase family NAD_binding_10 PF13460.6 ELR17640.1 - 1.6e-15 57.5 0.0 2.2e-15 57.0 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 ELR17640.1 - 1.2e-12 47.9 0.0 1.7e-12 47.4 0.0 1.2 1 0 0 1 1 1 1 NmrA-like family Epimerase PF01370.21 ELR17640.1 - 7.4e-12 45.2 0.0 1.4e-10 41.1 0.0 2.5 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 ELR17640.1 - 4.7e-11 42.2 0.0 3.7e-09 36.0 0.0 2.1 1 1 1 2 2 2 2 3-beta hydroxysteroid dehydrogenase/isomerase family RmlD_sub_bind PF04321.17 ELR17640.1 - 1.9e-07 30.5 0.0 4.1e-06 26.1 0.0 2.2 1 1 0 1 1 1 1 RmlD substrate binding domain GDP_Man_Dehyd PF16363.5 ELR17640.1 - 0.0077 15.7 0.0 0.02 14.3 0.0 1.6 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase adh_short PF00106.25 ELR17640.1 - 0.014 14.8 0.0 0.026 14.0 0.0 1.4 1 0 0 1 1 1 0 short chain dehydrogenase NAD_binding_4 PF07993.12 ELR17640.1 - 0.024 13.8 0.1 3.5 6.7 0.1 2.3 1 1 0 2 2 2 0 Male sterility protein Polysacc_synt_2 PF02719.15 ELR17640.1 - 0.043 13.0 0.0 0.16 11.1 0.0 1.8 1 1 0 1 1 1 0 Polysaccharide biosynthesis protein Adaptin_N PF01602.20 ELR17641.1 - 1.6e-111 373.5 0.0 2e-111 373.2 0.0 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Alpha_adaptin_C PF02296.16 ELR17641.1 - 2.5e-24 85.6 0.0 5.3e-24 84.6 0.0 1.6 1 0 0 1 1 1 1 Alpha adaptin AP2, C-terminal domain Alpha_adaptinC2 PF02883.20 ELR17641.1 - 1.3e-17 64.1 0.5 5.5e-17 62.1 0.1 2.3 2 0 0 2 2 2 1 Adaptin C-terminal domain Cnd1 PF12717.7 ELR17641.1 - 2.1e-05 24.6 0.0 0.0014 18.7 0.0 3.0 2 2 0 3 3 3 1 non-SMC mitotic condensation complex subunit 1 AP4E_app_platf PF14807.6 ELR17641.1 - 0.0036 17.6 0.1 0.011 16.0 0.0 1.8 2 0 0 2 2 2 1 Adaptin AP4 complex epsilon appendage platform HEAT_2 PF13646.6 ELR17641.1 - 0.01 16.2 0.3 7 7.1 0.0 3.6 2 2 0 2 2 2 0 HEAT repeats Vac14_Fab1_bd PF12755.7 ELR17641.1 - 0.11 13.1 0.1 2.4 8.8 0.0 2.6 2 0 0 2 2 2 0 Vacuolar 14 Fab1-binding region HEAT PF02985.22 ELR17641.1 - 0.16 12.3 2.0 21 5.7 0.0 4.7 5 0 0 5 5 5 0 HEAT repeat YfiO PF13525.6 ELR17641.1 - 0.23 11.2 0.8 0.51 10.0 0.3 1.8 2 0 0 2 2 2 0 Outer membrane lipoprotein DUF4930 PF16284.5 ELR17642.1 - 0.12 12.4 0.1 0.19 11.7 0.0 1.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4930) YecM PF06185.12 ELR17643.1 - 1.8e-30 105.9 0.0 1.9e-27 96.1 0.0 2.0 1 1 1 2 2 2 2 YecM protein Hamartin PF04388.12 ELR17645.1 - 1.4e-12 47.2 17.0 3.5e-12 45.8 0.0 2.6 2 1 0 2 2 2 1 Hamartin protein TPD52 PF04201.15 ELR17645.1 - 0.0022 17.6 1.4 0.0022 17.6 1.4 2.0 2 1 1 3 3 3 1 Tumour protein D52 family Baculo_PEP_C PF04513.12 ELR17645.1 - 3 7.9 5.7 0.73 9.9 2.2 1.7 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Arrestin_C PF02752.22 ELR17646.1 - 1.2e-10 41.9 0.2 1.9e-10 41.3 0.2 1.3 1 0 0 1 1 1 1 Arrestin (or S-antigen), C-terminal domain Rgp1 PF08737.10 ELR17646.1 - 0.098 11.8 0.1 1.6 7.8 0.0 2.1 2 0 0 2 2 2 0 Rgp1 Vps26 PF03643.15 ELR17646.1 - 0.1 11.6 0.1 0.15 11.0 0.1 1.2 1 0 0 1 1 1 0 Vacuolar protein sorting-associated protein 26 RNA_lig_T4_1 PF09511.10 ELR17647.1 - 6.6e-31 107.9 0.0 1.1e-30 107.2 0.0 1.3 1 0 0 1 1 1 1 RNA ligase RNA_ligase PF09414.10 ELR17647.1 - 6e-05 23.4 0.0 0.00013 22.3 0.0 1.6 1 0 0 1 1 1 1 RNA ligase FAD-oxidase_C PF02913.19 ELR17648.1 - 4.1e-48 164.2 0.3 7.2e-48 163.4 0.3 1.4 1 0 0 1 1 1 1 FAD linked oxidases, C-terminal domain FAD_binding_4 PF01565.23 ELR17648.1 - 3.9e-32 110.9 0.1 9.1e-32 109.7 0.1 1.7 1 0 0 1 1 1 1 FAD binding domain Fer4_7 PF12838.7 ELR17648.1 - 1.8e-08 34.8 3.3 7e-08 32.9 3.3 2.1 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_8 PF13183.6 ELR17648.1 - 3.6e-08 33.7 2.4 1.1e-07 32.2 2.4 1.9 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_17 PF13534.6 ELR17648.1 - 1.3e-06 28.8 5.5 1.8e-06 28.4 4.2 2.0 2 0 0 2 2 2 1 4Fe-4S dicluster domain Fer4_10 PF13237.6 ELR17648.1 - 5e-06 26.5 0.8 0.046 13.8 0.2 2.6 2 0 0 2 2 2 2 4Fe-4S dicluster domain Fer4_16 PF13484.6 ELR17648.1 - 2.5e-05 25.1 3.9 6.5e-05 23.8 3.9 1.8 1 0 0 1 1 1 1 4Fe-4S double cluster binding domain Fer4_9 PF13187.6 ELR17648.1 - 0.00051 20.2 4.5 0.0021 18.2 4.6 2.1 1 1 0 1 1 1 1 4Fe-4S dicluster domain Fer4 PF00037.27 ELR17648.1 - 0.0013 18.5 13.0 0.081 12.8 3.6 2.6 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_6 PF12837.7 ELR17648.1 - 0.017 15.2 12.1 0.069 13.3 2.5 3.0 2 0 0 2 2 2 0 4Fe-4S binding domain HCBP_related PF06594.11 ELR17648.1 - 0.17 11.8 0.0 0.35 10.8 0.0 1.5 1 0 0 1 1 1 0 Haemolysin-type calcium binding protein related domain Fer4_20 PF14691.6 ELR17648.1 - 0.19 11.5 1.7 1.3 8.8 0.0 2.3 2 0 0 2 2 2 0 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster Fer4_18 PF13746.6 ELR17648.1 - 0.22 11.7 1.5 32 4.8 0.3 2.9 3 0 0 3 3 3 0 4Fe-4S dicluster domain Fer4_2 PF12797.7 ELR17648.1 - 1.7 8.9 14.5 0.069 13.3 2.2 3.2 3 0 0 3 3 3 0 4Fe-4S binding domain VASt PF16016.5 ELR17649.1 - 3.9e-33 115.0 0.0 6.2e-33 114.4 0.0 1.3 1 0 0 1 1 1 1 VAD1 Analog of StAR-related lipid transfer domain GRAM PF02893.20 ELR17649.1 - 5.8e-19 68.1 0.8 9.9e-19 67.3 0.8 1.4 1 0 0 1 1 1 1 GRAM domain C2 PF00168.30 ELR17650.1 - 1.8e-14 53.9 0.0 5.8e-06 26.5 0.0 4.7 5 0 0 5 5 5 3 C2 domain Mre11_DNA_bind PF04152.14 ELR17651.1 - 1.6e-46 158.7 0.0 1.6e-46 158.7 0.0 2.6 2 1 0 2 2 2 1 Mre11 DNA-binding presumed domain Metallophos PF00149.28 ELR17651.1 - 1.6e-07 32.0 0.4 2.6e-07 31.3 0.4 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase DDHD PF02862.17 ELR17651.1 - 2 8.5 4.6 3.4 7.8 4.6 1.3 1 0 0 1 1 1 0 DDHD domain Nucleo_P87 PF07267.11 ELR17651.1 - 4.3 6.1 8.6 8.6 5.1 8.6 1.4 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 Mucin PF01456.17 ELR17651.1 - 8.5 6.4 12.1 18 5.3 12.1 1.6 1 0 0 1 1 1 0 Mucin-like glycoprotein PHD PF00628.29 ELR17652.1 - 0.00026 20.8 10.7 0.00052 19.8 10.7 1.5 1 0 0 1 1 1 1 PHD-finger SPX PF03105.19 ELR17653.1 - 0.87 9.4 7.0 1.4 8.7 7.0 1.4 1 1 0 1 1 1 0 SPX domain TFIIA PF03153.13 ELR17653.1 - 1 9.3 12.9 1.2 9.1 12.9 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Prenyltrans PF00432.21 ELR17654.1 - 2.1e-67 222.5 15.8 3.5e-15 55.5 0.0 6.1 6 0 0 6 6 6 5 Prenyltransferase and squalene oxidase repeat SQHop_cyclase_C PF13243.6 ELR17654.1 - 2.7e-05 23.5 0.1 0.0019 17.4 0.1 2.4 1 1 0 1 1 1 1 Squalene-hopene cyclase C-terminal domain SQHop_cyclase_N PF13249.6 ELR17654.1 - 0.00023 20.3 0.1 0.54 9.3 0.0 4.3 4 2 1 5 5 5 2 Squalene-hopene cyclase N-terminal domain DUF1394 PF07159.12 ELR17655.1 - 1.7e-104 349.3 0.0 4e-103 344.8 0.0 1.9 1 1 1 2 2 2 2 Protein of unknown function (DUF1394) Ribosomal_S24e PF01282.19 ELR17655.1 - 0.16 12.0 0.0 0.4 10.7 0.0 1.8 1 0 0 1 1 1 0 Ribosomal protein S24e Ras PF00071.22 ELR17656.1 - 8.3e-54 181.6 0.0 9.6e-54 181.3 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR17656.1 - 3.1e-22 79.0 0.0 5e-22 78.4 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR17656.1 - 4.5e-12 45.8 0.0 5.9e-12 45.4 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 ELR17656.1 - 0.00012 21.7 0.0 0.0002 20.9 0.0 1.4 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 ELR17656.1 - 0.043 13.9 0.0 0.069 13.2 0.0 1.4 1 1 0 1 1 1 0 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 ELR17656.1 - 0.079 12.3 0.0 0.11 11.8 0.0 1.5 1 1 0 1 1 1 0 Gtr1/RagA G protein conserved region RhoGEF PF00621.20 ELR17658.1 - 6.6e-38 130.8 0.0 1.4e-37 129.7 0.0 1.6 1 0 0 1 1 1 1 RhoGEF domain PH PF00169.29 ELR17658.1 - 0.012 16.1 0.0 0.22 12.0 0.0 2.5 2 0 0 2 2 2 0 PH domain PH_10 PF15411.6 ELR17658.1 - 2 8.7 0.0 2 8.7 0.0 3.5 3 1 0 3 3 3 0 Pleckstrin homology domain CKS PF01111.19 ELR17659.1 - 2.3e-36 123.9 0.2 2.7e-36 123.6 0.2 1.1 1 0 0 1 1 1 1 Cyclin-dependent kinase regulatory subunit Ank_2 PF12796.7 ELR17660.1 - 3.7e-61 203.7 10.7 9.7e-17 61.3 0.2 5.3 1 1 5 6 6 6 6 Ankyrin repeats (3 copies) Ank_5 PF13857.6 ELR17660.1 - 4.4e-41 138.4 13.2 2.2e-10 40.5 0.3 7.4 1 1 6 8 8 8 5 Ankyrin repeats (many copies) Ank_4 PF13637.6 ELR17660.1 - 1.8e-40 136.8 9.6 5.4e-09 36.4 0.7 7.3 4 1 4 8 8 8 6 Ankyrin repeats (many copies) Ank PF00023.30 ELR17660.1 - 2.3e-38 129.0 24.4 3.9e-06 27.1 0.2 9.6 10 0 0 10 10 10 8 Ankyrin repeat Ank_3 PF13606.6 ELR17660.1 - 4e-38 125.1 10.2 1.8e-05 24.7 0.0 9.8 10 0 0 10 10 10 8 Ankyrin repeat FIN1 PF17300.2 ELR17661.1 - 0.0021 17.6 0.7 0.0023 17.5 0.7 1.1 1 0 0 1 1 1 1 Filaments in between nuclei protein-1 Stathmin PF00836.19 ELR17661.1 - 0.0041 17.1 6.6 0.0047 16.9 6.6 1.2 1 0 0 1 1 1 1 Stathmin family DSPc PF00782.20 ELR17662.1 - 4.5e-05 23.3 0.0 8.3e-05 22.4 0.0 1.3 1 1 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 ELR17662.1 - 0.0024 17.9 0.0 0.0026 17.8 0.0 1.2 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase PF00102.27 ELR17662.1 - 0.14 11.7 0.0 0.18 11.3 0.0 1.2 1 0 0 1 1 1 0 Protein-tyrosine phosphatase Skp1_POZ PF03931.15 ELR17663.1 - 1.1e-13 51.1 0.0 2.3e-13 50.1 0.0 1.5 2 0 0 2 2 2 1 Skp1 family, tetramerisation domain BTB PF00651.31 ELR17663.1 - 0.0019 18.4 0.0 0.0023 18.1 0.0 1.3 1 1 0 1 1 1 1 BTB/POZ domain Ras PF00071.22 ELR17664.1 - 2.3e-20 72.8 0.0 3.2e-20 72.4 0.0 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR17664.1 - 2.2e-11 44.0 0.0 4.5e-11 43.0 0.0 1.5 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase RsgA_GTPase PF03193.16 ELR17664.1 - 0.0014 18.6 0.4 0.65 9.9 0.3 2.4 2 1 0 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 ELR17664.1 - 0.0023 18.0 0.1 0.0059 16.7 0.0 1.7 2 1 0 2 2 2 1 50S ribosome-binding GTPase Septin PF00735.18 ELR17664.1 - 0.0089 15.3 0.0 0.015 14.6 0.0 1.2 1 0 0 1 1 1 1 Septin AAA_16 PF13191.6 ELR17664.1 - 0.062 13.7 0.0 0.13 12.7 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain LRR_4 PF12799.7 ELR17665.1 - 2.6e-06 27.7 5.5 0.00024 21.4 0.7 4.9 4 1 1 5 5 5 1 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 ELR17665.1 - 5.7e-05 22.9 10.9 0.11 12.6 0.1 5.9 7 0 0 7 7 7 1 Leucine Rich repeat Acetyltransf_7 PF13508.7 ELR17665.1 - 6.6e-05 23.3 0.7 0.00032 21.1 0.7 2.0 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 ELR17665.1 - 0.0001 22.5 0.0 0.00054 20.2 0.0 2.1 2 0 0 2 2 2 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 ELR17665.1 - 0.0022 18.0 0.2 1.8 8.5 0.0 2.4 2 0 0 2 2 2 2 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 ELR17665.1 - 0.01 16.0 0.0 0.023 14.9 0.0 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain G6B PF15096.6 ELR17665.1 - 0.024 14.4 0.1 0.048 13.4 0.1 1.4 1 0 0 1 1 1 0 G6B family LRR_8 PF13855.6 ELR17665.1 - 0.035 13.9 1.0 0.47 10.3 0.1 2.9 2 1 0 2 2 2 0 Leucine rich repeat Acetyltransf_9 PF13527.7 ELR17665.1 - 0.17 12.0 0.1 1.2 9.2 0.0 2.2 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain LRR_1 PF00560.33 ELR17665.1 - 0.19 12.4 7.6 57 4.9 0.0 5.9 5 1 0 5 5 5 0 Leucine Rich Repeat RabGAP-TBC PF00566.18 ELR17666.1 - 2.6e-16 59.9 0.4 8.4e-15 55.0 0.4 2.1 1 1 0 1 1 1 1 Rab-GTPase-TBC domain Gluconate_2-dh3 PF13618.6 ELR17667.1 - 0.1 12.8 0.1 0.22 11.7 0.1 1.6 1 1 0 1 1 1 0 Gluconate 2-dehydrogenase subunit 3 NMD3 PF04981.13 ELR17668.1 - 2.1e-82 276.3 3.2 2.7e-82 275.9 3.2 1.1 1 0 0 1 1 1 1 NMD3 family DUF35_N PF12172.8 ELR17668.1 - 0.13 12.2 1.1 1.1 9.2 0.2 2.5 2 0 0 2 2 2 0 Rubredoxin-like zinc ribbon domain (DUF35_N) DZR PF12773.7 ELR17668.1 - 2.1 8.5 10.2 1.6e+02 2.4 10.2 2.8 1 1 0 1 1 1 0 Double zinc ribbon CpXC PF14353.6 ELR17668.1 - 2.5 8.2 6.2 6.8 6.8 0.1 2.7 2 1 0 2 2 2 0 CpXC protein CCDC53 PF10152.9 ELR17669.1 - 8.7e-58 195.1 33.0 1.4e-05 25.6 0.7 15.8 7 7 9 16 16 16 15 Subunit CCDC53 of WASH complex HemN_C PF06969.16 ELR17669.1 - 4.5e-15 55.5 0.0 2.7 8.1 0.0 12.0 14 1 1 15 15 15 3 HemN C-terminal domain Phage_integrase PF00589.22 ELR17669.1 - 0.0049 16.7 3.3 22 4.8 0.0 6.9 8 0 0 8 8 8 1 Phage integrase family Involucrin_N PF10583.9 ELR17669.1 - 0.29 11.7 4.5 5.3 7.7 0.1 4.3 4 1 1 5 5 5 0 Involucrin of squamous epithelia N-terminus Ras PF00071.22 ELR17670.1 - 1.7e-44 151.3 0.0 3e-44 150.5 0.0 1.3 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR17670.1 - 3.5e-17 62.7 0.0 6.4e-17 61.9 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR17670.1 - 6e-06 25.8 0.0 1e-05 25.1 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family 2OG-FeII_Oxy PF03171.20 ELR17670.1 - 0.05 14.1 0.0 0.13 12.7 0.0 1.8 1 0 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily DUF4554 PF15091.6 ELR17670.1 - 0.16 10.8 0.4 0.31 9.9 0.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4554) adh_short_C2 PF13561.6 ELR17671.1 - 2e-54 184.6 0.0 3.2e-54 184.0 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 ELR17671.1 - 2.7e-53 180.4 0.1 3.4e-53 180.0 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 ELR17671.1 - 6.4e-13 49.0 0.0 1e-12 48.4 0.0 1.3 1 0 0 1 1 1 1 KR domain Homeodomain PF00046.29 ELR17672.1 - 2.6e-13 49.6 0.0 7.5e-13 48.1 0.0 1.8 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 ELR17672.1 - 0.034 14.0 0.0 0.096 12.6 0.0 1.8 1 0 0 1 1 1 0 Homeobox KN domain Pneumo_att_G PF05539.11 ELR17672.1 - 0.22 11.1 11.0 0.35 10.4 11.0 1.3 1 0 0 1 1 1 0 Pneumovirinae attachment membrane glycoprotein G DUF1080 PF06439.11 ELR17673.1 - 0.00079 19.6 0.0 0.0012 18.9 0.0 1.4 1 1 0 1 1 1 1 Domain of Unknown Function (DUF1080) IHABP4_N PF16174.5 ELR17674.1 - 0.24 12.0 11.6 0.63 10.6 11.6 1.7 1 0 0 1 1 1 0 Intracellular hyaluronan-binding protein 4 N-terminal NST1 PF13945.6 ELR17674.1 - 0.3 11.2 14.4 0.69 10.0 14.4 1.6 1 0 0 1 1 1 0 Salt tolerance down-regulator zf-CCHC_4 PF14392.6 ELR17674.1 - 0.37 10.6 5.7 0.71 9.6 5.7 1.5 1 0 0 1 1 1 0 Zinc knuckle Hid1 PF12722.7 ELR17674.1 - 0.95 7.5 6.4 1.4 6.9 6.4 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein zf-CCHC PF00098.23 ELR17674.1 - 1.9 8.7 6.5 3.4 7.9 6.5 1.4 1 0 0 1 1 1 0 Zinc knuckle NPR3 PF03666.13 ELR17674.1 - 7.7 5.2 8.7 12 4.6 8.7 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Vps54 PF07928.12 ELR17675.1 - 2.7e-43 147.6 0.8 2.7e-43 147.6 0.8 3.2 3 0 0 3 3 3 1 Vps54-like protein Vps54_N PF10475.9 ELR17675.1 - 1.6e-13 50.6 4.0 2.6e-13 49.9 1.5 2.3 2 0 0 2 2 2 1 Vacuolar-sorting protein 54, of GARP complex DUF2451 PF10474.9 ELR17675.1 - 0.00027 20.8 0.1 0.0012 18.7 0.0 2.1 2 0 0 2 2 2 1 Protein of unknown function C-terminus (DUF2451) DUF3510 PF12022.8 ELR17675.1 - 0.53 10.7 4.7 0.95 9.9 0.2 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF3510) Dabb PF07876.12 ELR17676.1 - 7.3e-25 87.4 0.0 8e-25 87.3 0.0 1.0 1 0 0 1 1 1 1 Stress responsive A/B Barrel Domain PPTA PF01239.22 ELR17677.1 - 1e-41 139.5 23.4 1.3e-11 43.8 0.3 5.7 6 0 0 6 6 6 5 Protein prenyltransferase alpha subunit repeat HetR_C PF18460.1 ELR17677.1 - 0.15 12.0 3.3 0.3 11.0 0.2 2.7 3 0 0 3 3 3 0 Heterocyst differentiation regulator C-terminal Hood domain Retrotran_gag_3 PF14244.6 ELR17677.1 - 0.26 11.1 1.2 7.1 6.5 0.0 3.0 3 0 0 3 3 3 0 gag-polypeptide of LTR copia-type Ribosomal_S14 PF00253.21 ELR17678.1 - 4.4e-13 48.8 4.3 6.5e-13 48.2 4.3 1.3 1 0 0 1 1 1 1 Ribosomal protein S14p/S29e EI24 PF07264.11 ELR17679.1 - 2.2e-13 50.9 21.7 2.8e-13 50.5 21.7 1.1 1 0 0 1 1 1 1 Etoposide-induced protein 2.4 (EI24) Pox_E8 PF03394.13 ELR17679.1 - 0.0019 17.8 0.1 0.0038 16.8 0.1 1.4 1 0 0 1 1 1 1 Poxvirus E8 protein ETC_C1_NDUFA4 PF04800.12 ELR17680.1 - 2.1e-31 108.1 0.2 3.1e-31 107.5 0.2 1.2 1 0 0 1 1 1 1 ETC complex I subunit conserved region SAM_1 PF00536.30 ELR17681.1 - 1.3e-08 35.1 0.2 7.2e-05 23.2 0.0 2.3 2 0 0 2 2 2 2 SAM domain (Sterile alpha motif) PB1 PF00564.24 ELR17681.1 - 3.7e-06 26.8 0.1 6.2e-06 26.1 0.1 1.4 1 0 0 1 1 1 1 PB1 domain SAM_2 PF07647.17 ELR17681.1 - 8.6e-06 25.8 0.1 0.00032 20.8 0.0 2.3 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) R3H PF01424.22 ELR17682.1 - 2e-05 24.5 0.1 0.0001 22.2 0.0 2.1 2 0 0 2 2 2 1 R3H domain Cpn60_TCP1 PF00118.24 ELR17683.1 - 1.8e-169 564.5 3.2 2.1e-169 564.3 3.2 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family CdhD PF03599.16 ELR17683.1 - 0.035 12.8 0.0 0.09 11.5 0.0 1.6 2 0 0 2 2 2 0 CO dehydrogenase/acetyl-CoA synthase delta subunit MAPEG PF01124.18 ELR17684.1 - 1.1e-13 51.3 2.5 1.3e-13 50.9 2.5 1.2 1 0 0 1 1 1 1 MAPEG family CK2S PF15011.6 ELR17685.1 - 0.00029 20.8 0.4 0.0004 20.3 0.4 1.1 1 0 0 1 1 1 1 Casein Kinase 2 substrate DUF1570 PF07607.11 ELR17685.1 - 0.097 13.0 0.0 0.15 12.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1570) RRM_1 PF00076.22 ELR17686.1 - 1.3e-41 140.2 0.0 3.8e-17 61.9 0.1 4.2 3 1 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-met PF12874.7 ELR17686.1 - 4.5e-07 30.0 0.2 4.5e-07 30.0 0.2 2.1 3 0 0 3 3 3 1 Zinc-finger of C2H2 type RRM_7 PF16367.5 ELR17686.1 - 4.4e-06 26.7 0.0 0.039 14.1 0.0 3.4 3 0 0 3 3 3 2 RNA recognition motif zf-C2H2_jaz PF12171.8 ELR17686.1 - 7.4e-05 22.9 0.1 7.4e-05 22.9 0.1 2.4 3 0 0 3 3 3 1 Zinc-finger double-stranded RNA-binding RRM_5 PF13893.6 ELR17686.1 - 0.0033 17.0 0.0 0.27 10.8 0.0 2.5 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 ELR17686.1 - 0.016 15.2 0.0 13 5.8 0.0 3.3 3 0 0 3 3 3 0 Nup53/35/40-type RNA recognition motif RRM_occluded PF16842.5 ELR17686.1 - 0.18 11.7 0.0 0.9 9.4 0.0 2.1 2 0 0 2 2 2 0 Occluded RNA-recognition motif Helicase_C PF00271.31 ELR17687.1 - 5e-08 33.3 0.0 6.5e-08 32.9 0.0 1.2 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ITI_HC_C PF06668.12 ELR17687.1 - 0.0039 16.9 0.0 0.0047 16.6 0.0 1.3 1 0 0 1 1 1 1 Inter-alpha-trypsin inhibitor heavy chain C-terminus SNF2_N PF00176.23 ELR17688.1 - 0.0035 16.1 0.6 0.01 14.6 0.5 1.7 1 1 0 1 1 1 1 SNF2 family N-terminal domain Endostatin PF06482.11 ELR17690.1 - 0.45 9.9 3.6 0.31 10.5 1.3 1.7 2 0 0 2 2 2 0 Collagenase NC10 and Endostatin IHABP4_N PF16174.5 ELR17690.1 - 2.1 8.9 15.4 3.4 8.2 15.4 1.3 1 0 0 1 1 1 0 Intracellular hyaluronan-binding protein 4 N-terminal NARP1 PF12569.8 ELR17690.1 - 3.8 6.3 11.2 3.5 6.4 10.0 1.5 2 0 0 2 2 2 0 NMDA receptor-regulated protein 1 FliO PF04347.13 ELR17691.1 - 0.036 14.3 0.0 0.044 14.1 0.0 1.2 1 0 0 1 1 1 0 Flagellar biosynthesis protein, FliO Pkinase_Tyr PF07714.17 ELR17693.1 - 1.8e-95 319.1 0.0 9.9e-56 188.9 0.0 2.5 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 ELR17693.1 - 5.6e-80 268.5 0.0 2.6e-48 164.7 0.0 2.4 2 1 0 2 2 2 2 Protein kinase domain PBP_like_2 PF12849.7 ELR17693.1 - 1.3e-35 123.5 5.0 1.4e-19 70.9 0.1 2.2 2 0 0 2 2 2 2 PBP superfamily domain Guanylate_cyc PF00211.20 ELR17693.1 - 1.3e-09 38.0 0.0 9.6e-05 22.1 0.0 2.3 2 0 0 2 2 2 2 Adenylate and Guanylate cyclase catalytic domain TMEM154 PF15102.6 ELR17693.1 - 0.02 14.8 0.0 0.052 13.4 0.0 1.6 1 0 0 1 1 1 0 TMEM154 protein family Zip PF02535.22 ELR17693.1 - 0.039 13.2 1.7 2.8 7.1 0.4 2.2 2 0 0 2 2 2 0 ZIP Zinc transporter HMD PF03201.16 ELR17693.1 - 0.14 12.4 0.0 0.36 11.1 0.0 1.7 1 0 0 1 1 1 0 H2-forming N5,N10-methylene-tetrahydromethanopterin dehydrogenase FTA2 PF13095.6 ELR17693.1 - 0.19 11.4 0.0 0.34 10.5 0.0 1.3 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 EGF_2 PF07974.13 ELR17693.1 - 0.97 9.9 17.6 1.9 8.9 17.6 1.5 1 0 0 1 1 1 0 EGF-like domain MFS_1 PF07690.16 ELR17694.1 - 3.5e-25 88.7 40.7 5.2e-13 48.6 25.8 2.4 2 1 0 2 2 2 2 Major Facilitator Superfamily Ras PF00071.22 ELR17695.1 - 2.3e-54 183.4 0.0 2.6e-54 183.2 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR17695.1 - 1.3e-20 73.8 0.0 2e-20 73.2 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR17695.1 - 3.5e-08 33.1 0.0 4.3e-08 32.8 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 ELR17695.1 - 0.033 13.7 0.0 0.15 11.6 0.0 1.9 2 1 0 2 2 2 0 Elongation factor Tu GTP binding domain Nkap_C PF06047.11 ELR17696.1 - 1.9e-47 159.6 3.5 1.9e-47 159.6 3.5 2.5 2 1 1 3 3 3 1 NF-kappa-B-activating protein C-terminal domain Ndc1_Nup PF09531.10 ELR17696.1 - 0.43 9.2 10.4 0.53 8.9 10.4 1.3 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Mucin PF01456.17 ELR17696.1 - 0.43 10.6 1.7 0.8 9.7 1.7 1.4 1 0 0 1 1 1 0 Mucin-like glycoprotein Mem_trans PF03547.18 ELR17696.1 - 2.7 6.3 5.2 3.3 6.0 5.2 1.4 1 0 0 1 1 1 0 Membrane transport protein Ring_hydroxyl_A PF00848.19 ELR17697.1 - 3.9e-38 131.6 2.1 9.4e-38 130.3 2.1 1.6 1 1 0 1 1 1 1 Ring hydroxylating alpha subunit (catalytic domain) Rieske PF00355.26 ELR17697.1 - 1.3e-14 53.9 0.0 2.5e-14 53.0 0.0 1.4 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain LapA_dom PF06305.11 ELR17698.1 - 2.8 7.8 3.9 1.8 8.4 0.2 2.1 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain Peptidase_C65 PF10275.9 ELR17699.1 - 1.3e-40 139.4 0.0 1.5e-40 139.2 0.0 1.0 1 0 0 1 1 1 1 Peptidase C65 Otubain OTU PF02338.19 ELR17699.1 - 7e-05 23.3 0.0 0.12 12.9 0.0 2.3 1 1 1 2 2 2 2 OTU-like cysteine protease DUF2126 PF09899.9 ELR17699.1 - 0.05 11.7 0.0 0.056 11.5 0.0 1.0 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) Peptidase_C101 PF16218.5 ELR17699.1 - 0.057 12.7 0.0 3.4 6.9 0.0 2.3 2 0 0 2 2 2 0 Peptidase family C101 ubiquitin PF00240.23 ELR17700.1 - 4.5e-16 58.4 0.1 5.4e-16 58.1 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 ELR17700.1 - 5.4e-10 39.0 0.1 7.2e-10 38.6 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 ELR17700.1 - 0.0038 17.6 0.1 0.011 16.2 0.1 1.7 1 1 0 1 1 1 1 Ubiquitin-like domain DUF550 PF04447.12 ELR17700.1 - 0.059 13.5 0.0 0.07 13.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF550) Pet191_N PF10203.9 ELR17701.1 - 2.8e-18 66.0 9.1 6.3e-18 64.8 9.1 1.5 1 1 0 1 1 1 1 Cytochrome c oxidase assembly protein PET191 CX9C PF16860.5 ELR17701.1 - 0.041 13.9 4.8 1.7 8.7 0.2 2.6 1 1 1 2 2 2 0 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, SIR2 PF02146.17 ELR17703.1 - 1.3e-16 61.1 0.1 1.7e-16 60.6 0.1 1.2 1 0 0 1 1 1 1 Sir2 family SIR2 PF02146.17 ELR17704.1 - 5.2e-28 98.2 0.0 1.1e-27 97.1 0.0 1.5 2 0 0 2 2 2 1 Sir2 family Aminotran_4 PF01063.19 ELR17705.1 - 5.5e-32 111.4 0.0 7.4e-32 111.0 0.0 1.2 1 0 0 1 1 1 1 Amino-transferase class IV FYRC PF05965.14 ELR17705.1 - 0.15 12.2 0.0 0.32 11.2 0.0 1.5 1 0 0 1 1 1 0 F/Y rich C-terminus F-box-like PF12937.7 ELR17706.1 - 1.3e-06 28.2 0.2 2.7e-06 27.1 0.2 1.5 1 0 0 1 1 1 1 F-box-like F-box-like PF12937.7 ELR17707.1 - 2.6e-08 33.6 1.4 4.8e-08 32.8 0.5 1.9 2 0 0 2 2 2 1 F-box-like zf-MYND PF01753.18 ELR17709.1 - 7.1e-11 42.0 5.5 1.5e-10 41.0 5.5 1.5 1 0 0 1 1 1 1 MYND finger zf-C6H2 PF15801.5 ELR17709.1 - 3.6 8.0 8.7 0.2 12.0 2.4 2.0 2 0 0 2 2 2 0 zf-MYND-like zinc finger, mRNA-binding SAM_1 PF00536.30 ELR17710.1 - 3.3e-05 24.2 0.4 6.6e-05 23.3 0.1 1.5 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 ELR17710.1 - 0.00017 21.7 0.1 0.0003 20.8 0.1 1.3 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) zinc_ribbon_9 PF14369.6 ELR17710.1 - 0.02 15.1 2.8 0.02 15.1 2.8 2.6 3 1 0 3 3 3 0 zinc-ribbon zf-C3HC4_4 PF15227.6 ELR17710.1 - 0.18 12.0 7.0 1.3 9.3 7.0 2.3 1 1 0 1 1 1 0 zinc finger of C3HC4-type, RING MOR2-PAG1_N PF14222.6 ELR17711.1 - 1.1e-54 186.3 1.2 1.1e-54 186.3 1.2 1.8 2 0 0 2 2 2 1 Cell morphogenesis N-terminal MOR2-PAG1_C PF14225.6 ELR17711.1 - 6.7e-41 140.8 1.3 3.1e-40 138.6 0.1 2.5 2 0 0 2 2 2 1 Cell morphogenesis C-terminal MOR2-PAG1_mid PF14228.6 ELR17711.1 - 2.3e-38 131.6 0.7 2.6e-16 58.5 0.1 4.5 3 2 1 4 4 4 3 Cell morphogenesis central region IFRD PF05004.13 ELR17711.1 - 0.00081 18.6 1.8 0.042 12.9 0.1 2.6 1 1 1 2 2 2 2 Interferon-related developmental regulator (IFRD) Transp_inhibit PF18791.1 ELR17711.1 - 0.015 14.8 0.1 0.04 13.4 0.1 1.7 1 0 0 1 1 1 0 Transport inhibitor response 1 protein domain Vps62 PF06101.11 ELR17712.1 - 1.7e-11 43.1 0.1 3.5e-11 42.1 0.0 1.4 2 0 0 2 2 2 1 Vacuolar protein sorting-associated protein 62 DnaJ_CXXCXGXG PF00684.19 ELR17712.1 - 0.0011 19.2 13.3 0.0025 18.2 6.8 2.5 1 1 0 2 2 2 2 DnaJ central domain TrmB PF01978.19 ELR17713.1 - 0.0094 15.8 0.0 0.021 14.7 0.0 1.5 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB HTH_Crp_2 PF13545.6 ELR17713.1 - 0.064 13.2 0.2 0.18 11.8 0.2 1.7 1 0 0 1 1 1 0 Crp-like helix-turn-helix domain HTH_5 PF01022.20 ELR17713.1 - 0.15 11.9 0.0 0.35 10.8 0.0 1.6 1 0 0 1 1 1 0 Bacterial regulatory protein, arsR family E2F_TDP PF02319.20 ELR17713.1 - 0.2 11.7 0.0 0.43 10.7 0.0 1.5 1 0 0 1 1 1 0 E2F/DP family winged-helix DNA-binding domain Zip PF02535.22 ELR17714.1 - 1.4e-22 80.3 13.7 3.7e-19 69.1 0.7 2.2 2 0 0 2 2 2 2 ZIP Zinc transporter eIF-5_eIF-2B PF01873.17 ELR17716.1 - 2.8e-12 46.5 0.6 1e-10 41.5 0.0 2.8 2 1 0 2 2 2 1 Domain found in IF2B/IF5 SAPS PF04499.15 ELR17717.1 - 4.2e-23 81.9 0.1 2e-14 53.3 0.0 3.2 3 1 0 3 3 3 2 SIT4 phosphatase-associated protein SET PF00856.28 ELR17718.1 - 6.4e-14 52.7 0.0 3.8e-13 50.2 0.0 2.1 1 1 0 1 1 1 1 SET domain ClpS PF02617.17 ELR17718.1 - 0.0042 16.8 0.4 0.011 15.5 0.4 1.8 1 0 0 1 1 1 1 ATP-dependent Clp protease adaptor protein ClpS SAF PF08666.12 ELR17718.1 - 0.032 14.8 0.0 6.1 7.5 0.0 2.4 2 0 0 2 2 2 0 SAF domain SUB1_ProdP9 PF18213.1 ELR17718.1 - 0.048 13.5 0.0 0.093 12.6 0.0 1.5 1 0 0 1 1 1 0 SUB1 protease Prodomain ProdP9 SR-25 PF10500.9 ELR17718.1 - 3.4 7.2 12.5 2.3 7.8 9.6 1.9 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein AAA_34 PF13872.6 ELR17719.1 - 1.2e-114 382.3 0.5 3.5e-114 380.8 0.0 2.0 3 0 0 3 3 3 1 P-loop containing NTP hydrolase pore-1 Helicase_C_4 PF13871.6 ELR17719.1 - 7.1e-81 271.8 0.0 1.8e-80 270.5 0.0 1.8 1 0 0 1 1 1 1 C-terminal domain on Strawberry notch homologue Amino_oxidase PF01593.24 ELR17721.1 - 1.2e-89 301.7 0.1 2.3e-65 221.7 0.0 2.6 3 0 0 3 3 3 2 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 ELR17721.1 - 7.4e-15 54.9 0.3 1.7e-14 53.8 0.3 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain SWIRM PF04433.17 ELR17721.1 - 4.9e-09 36.4 0.0 1.2e-08 35.2 0.0 1.6 1 0 0 1 1 1 1 SWIRM domain DAO PF01266.24 ELR17721.1 - 4.7e-08 33.0 0.0 1.2e-07 31.7 0.0 1.7 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 ELR17721.1 - 3.7e-07 29.7 0.1 4.3e-05 22.9 0.0 2.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 ELR17721.1 - 1.1e-06 27.6 0.4 3.1e-06 26.1 0.4 1.7 1 0 0 1 1 1 1 HI0933-like protein FAD_oxidored PF12831.7 ELR17721.1 - 7.8e-06 25.5 0.1 7.8e-06 25.5 0.1 1.8 2 0 0 2 2 1 1 FAD dependent oxidoreductase Thi4 PF01946.17 ELR17721.1 - 2.6e-05 23.6 0.0 2.6e-05 23.6 0.0 1.6 2 0 0 2 2 1 1 Thi4 family FAD_binding_2 PF00890.24 ELR17721.1 - 7.5e-05 22.0 2.4 7.5e-05 22.0 2.4 1.6 2 0 0 2 2 2 1 FAD binding domain Pyr_redox PF00070.27 ELR17721.1 - 8.5e-05 23.0 3.6 0.00036 21.0 0.2 3.2 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 ELR17721.1 - 0.00072 18.7 0.6 0.00072 18.7 0.6 2.0 2 0 0 2 2 2 1 Glucose inhibited division protein A FAD_binding_3 PF01494.19 ELR17721.1 - 0.00087 18.6 0.3 0.0026 17.1 0.3 1.8 1 0 0 1 1 1 1 FAD binding domain AlaDh_PNT_C PF01262.21 ELR17721.1 - 0.0016 17.8 0.2 0.0043 16.4 0.2 1.6 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain Pyr_redox_3 PF13738.6 ELR17721.1 - 0.0017 17.7 0.0 0.0017 17.7 0.0 1.7 2 0 0 2 2 1 1 Pyridine nucleotide-disulphide oxidoreductase XdhC_C PF13478.6 ELR17721.1 - 0.22 12.0 1.1 0.95 10.0 0.0 2.8 3 0 0 3 3 1 0 XdhC Rossmann domain Lycopene_cycl PF05834.12 ELR17721.1 - 1.6 7.7 9.8 0.058 12.4 0.3 2.4 2 0 0 2 2 2 0 Lycopene cyclase protein Dicty_REP PF05086.12 ELR17721.1 - 3.3 5.6 9.3 6 4.7 9.3 1.4 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein GATA PF00320.27 ELR17722.1 - 1.8e-10 40.3 8.1 3.1e-10 39.5 8.1 1.4 1 0 0 1 1 1 1 GATA zinc finger zf-C2H2_3 PF13878.6 ELR17722.1 - 0.25 11.2 2.0 0.59 10.0 0.0 2.2 2 0 0 2 2 2 0 zinc-finger of acetyl-transferase ESCO OPT PF03169.15 ELR17723.1 - 6.8e-120 401.6 31.5 5.8e-71 239.9 27.1 2.0 1 1 1 2 2 2 2 OPT oligopeptide transporter protein QCR10 PF09796.9 ELR17723.1 - 9.2 6.4 9.4 39 4.4 0.1 3.6 3 0 0 3 3 3 0 Ubiquinol-cytochrome-c reductase complex subunit (QCR10) UQ_con PF00179.26 ELR17724.1 - 7.7e-54 181.2 0.0 8.7e-54 181.0 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 ELR17724.1 - 2e-05 24.3 0.0 2.3e-05 24.1 0.0 1.1 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.22 ELR17724.1 - 0.0049 17.1 0.0 0.0064 16.8 0.0 1.3 1 0 0 1 1 1 1 RWD domain UFC1 PF08694.11 ELR17724.1 - 0.11 12.2 0.0 0.15 11.7 0.0 1.3 1 0 0 1 1 1 0 Ubiquitin-fold modifier-conjugating enzyme 1 Ammonium_transp PF00909.21 ELR17725.1 - 5.5e-41 140.6 24.7 8.5e-41 140.0 24.7 1.2 1 0 0 1 1 1 1 Ammonium Transporter Family PRO8NT PF08082.11 ELR17725.1 - 0.046 13.7 0.5 0.088 12.7 0.5 1.4 1 0 0 1 1 1 0 PRO8NT (NUC069), PrP8 N-terminal domain DUF2207 PF09972.9 ELR17725.1 - 0.15 10.8 9.6 0.38 9.5 0.1 3.2 3 0 0 3 3 3 0 Predicted membrane protein (DUF2207) Drf_GBD PF06371.13 ELR17725.1 - 1.3 8.5 4.4 2.5 7.6 4.4 1.4 1 0 0 1 1 1 0 Diaphanous GTPase-binding Domain Thioredoxin PF00085.20 ELR17727.1 - 0.031 14.2 0.1 0.6 10.1 0.1 2.2 2 0 0 2 2 2 0 Thioredoxin Arm PF00514.23 ELR17728.1 - 6.6e-18 64.1 6.4 0.0027 17.7 0.0 10.9 12 0 0 12 12 12 2 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.6 ELR17728.1 - 2.9e-10 40.4 20.8 0.053 13.9 0.4 7.8 4 2 6 10 10 10 5 HEAT repeats HEAT PF02985.22 ELR17728.1 - 1.9e-07 30.7 3.5 4 8.0 0.0 8.7 10 0 0 10 10 10 1 HEAT repeat Atx10homo_assoc PF09759.9 ELR17728.1 - 5.3e-07 29.6 0.4 1.5 8.9 0.0 6.1 6 0 0 6 6 6 2 Spinocerebellar ataxia type 10 protein domain HEAT_EZ PF13513.6 ELR17728.1 - 7.9e-06 26.3 14.9 9.6e-05 22.8 1.8 6.3 6 0 0 6 6 6 1 HEAT-like repeat Mus7 PF09462.10 ELR17728.1 - 0.006 15.5 2.2 0.01 14.8 2.2 1.3 1 0 0 1 1 1 1 Mus7/MMS22 family FANCI_HD2 PF14680.6 ELR17728.1 - 0.032 13.5 0.8 0.067 12.4 0.8 1.5 1 0 0 1 1 1 0 FANCI helical domain 2 Herpes_IE1 PF07340.11 ELR17728.1 - 0.039 12.9 0.5 0.11 11.4 0.5 1.7 1 0 0 1 1 1 0 Cytomegalovirus IE1 protein Imm5 PF14423.6 ELR17728.1 - 0.076 13.2 0.5 0.2 11.9 0.5 1.7 1 0 0 1 1 1 0 Immunity protein Imm5 DUF5615 PF18480.1 ELR17728.1 - 0.11 12.3 0.0 0.33 10.7 0.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF5615) DUF4635 PF15466.6 ELR17728.1 - 0.11 12.0 4.2 0.25 10.9 4.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4635) Glyco_hydro_cc PF11790.8 ELR17729.1 - 0.00014 21.5 0.4 0.00026 20.7 0.4 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase catalytic core IBR PF01485.21 ELR17730.1 - 1.9e-19 69.6 38.7 7e-14 51.8 2.5 5.8 6 0 0 6 6 6 3 IBR domain, a half RING-finger domain KHA PF11834.8 ELR17730.1 - 7.3e-09 35.6 0.0 1.4e-08 34.7 0.0 1.5 1 0 0 1 1 1 1 KHA, dimerisation domain of potassium ion channel zf-RanBP PF00641.18 ELR17730.1 - 8.3e-06 25.0 1.6 8.3e-06 25.0 1.6 4.3 4 0 0 4 4 4 1 Zn-finger in Ran binding protein and others zf-RING_UBOX PF13445.6 ELR17730.1 - 0.00011 22.2 1.3 0.00011 22.2 1.3 4.8 5 0 0 5 5 5 2 RING-type zinc-finger zf-C3HC4_2 PF13923.6 ELR17730.1 - 0.0025 17.6 5.5 0.0025 17.6 5.5 5.7 7 0 0 7 7 7 3 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 ELR17730.1 - 0.0025 18.1 3.8 0.0025 18.1 3.8 6.7 6 2 1 7 7 7 2 Ring finger domain zf-RING_5 PF14634.6 ELR17730.1 - 0.0079 16.1 1.1 0.0079 16.1 1.1 5.8 6 2 1 7 7 7 1 zinc-RING finger domain zf-C3HC4 PF00097.25 ELR17730.1 - 0.011 15.6 3.5 0.011 15.6 3.5 4.8 6 1 0 6 6 6 0 Zinc finger, C3HC4 type (RING finger) Zn_Tnp_IS91 PF14319.6 ELR17730.1 - 3.6 7.7 22.6 2.7 8.1 0.3 4.5 4 0 0 4 4 4 0 Transposase zinc-binding domain DpnI PF06044.12 ELR17730.1 - 7 6.2 11.6 1.4 8.5 1.2 3.1 3 0 0 3 3 3 0 Dam-replacing family ECH_2 PF16113.5 ELR17732.1 - 1.2e-128 429.4 0.0 1.4e-128 429.1 0.0 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_1 PF00378.20 ELR17732.1 - 2.3e-28 99.2 0.0 8.7e-26 90.7 0.0 2.8 1 1 1 2 2 2 2 Enoyl-CoA hydratase/isomerase LRR_8 PF13855.6 ELR17733.1 - 5.9e-69 227.7 85.8 7.7e-09 35.2 2.0 14.6 8 3 8 16 16 16 13 Leucine rich repeat LRR_4 PF12799.7 ELR17733.1 - 8.6e-61 200.8 81.2 2.1e-06 28.0 2.2 17.5 10 3 9 21 21 21 18 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 ELR17733.1 - 4e-11 42.7 26.4 0.11 11.9 1.9 7.2 2 1 4 7 7 7 7 Leucine-rich repeat F-box-like PF12937.7 ELR17733.1 - 1.8e-10 40.5 6.4 1.9e-10 40.5 3.3 2.9 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 ELR17733.1 - 9.5e-05 22.2 3.0 0.00066 19.5 3.0 2.6 1 0 0 1 1 1 1 F-box domain LRR_6 PF13516.6 ELR17733.1 - 0.0011 18.9 52.1 1.9 8.8 0.2 13.5 13 0 0 13 13 13 4 Leucine Rich repeat LRR_1 PF00560.33 ELR17733.1 - 0.01 16.3 64.1 1.4 9.7 0.6 18.3 19 3 1 20 20 20 0 Leucine Rich Repeat SR-25 PF10500.9 ELR17733.1 - 8.1 6.0 16.1 21 4.6 14.6 2.1 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein HGTP_anticodon2 PF12745.7 ELR17733.1 - 8.9 5.7 8.5 0.94 8.9 2.1 2.1 2 0 0 2 2 2 0 Anticodon binding domain of tRNAs LRR_8 PF13855.6 ELR17734.1 - 1.2e-34 117.9 51.3 3.2e-09 36.4 9.7 6.2 2 1 5 7 7 7 7 Leucine rich repeat LRR_4 PF12799.7 ELR17734.1 - 3.4e-27 94.1 56.5 2.9e-05 24.3 2.7 8.6 2 2 9 11 11 11 11 Leucine Rich repeats (2 copies) Patatin PF01734.22 ELR17734.1 - 1.2e-21 77.9 0.1 3.3e-21 76.4 0.1 1.8 1 1 0 1 1 1 1 Patatin-like phospholipase LRR_1 PF00560.33 ELR17734.1 - 0.00017 21.7 33.9 17 6.5 0.1 11.4 10 2 0 10 10 10 1 Leucine Rich Repeat Arm PF00514.23 ELR17734.1 - 0.0015 18.5 2.1 1.5 9.0 0.0 3.8 3 0 0 3 3 3 2 Armadillo/beta-catenin-like repeat LRR_9 PF14580.6 ELR17734.1 - 0.026 14.1 16.8 0.19 11.2 1.4 4.0 2 1 2 4 4 4 0 Leucine-rich repeat LRR_6 PF13516.6 ELR17734.1 - 3.3 8.0 41.2 4.4 7.6 0.1 10.4 10 0 0 10 10 10 0 Leucine Rich repeat Glutaredoxin PF00462.24 ELR17735.1 - 4e-21 75.0 0.0 5.6e-21 74.5 0.0 1.2 1 0 0 1 1 1 1 Glutaredoxin Thioredoxin_2 PF13098.6 ELR17735.1 - 0.0013 19.1 0.1 0.0015 19.0 0.1 1.3 1 1 0 1 1 1 1 Thioredoxin-like domain DSBA PF01323.20 ELR17735.1 - 0.012 15.4 1.5 1.9 8.2 0.4 2.1 1 1 1 2 2 2 0 DSBA-like thioredoxin domain DUF836 PF05768.14 ELR17735.1 - 0.014 15.8 0.0 0.018 15.4 0.0 1.4 1 1 0 1 1 1 0 Glutaredoxin-like domain (DUF836) Thioredoxin_3 PF13192.6 ELR17735.1 - 0.019 15.0 0.0 0.039 14.0 0.0 1.5 1 1 0 1 1 1 0 Thioredoxin domain Thioredoxin_4 PF13462.6 ELR17735.1 - 0.02 15.1 0.5 0.15 12.2 0.2 2.0 1 1 1 2 2 2 0 Thioredoxin GST_N_3 PF13417.6 ELR17735.1 - 0.042 14.3 0.0 0.059 13.8 0.0 1.3 1 1 0 1 1 1 0 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 ELR17735.1 - 0.052 13.9 0.0 0.063 13.6 0.0 1.3 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain DUF2177 PF09945.9 ELR17736.1 - 3.1e-21 75.8 6.4 4e-21 75.4 6.4 1.1 1 0 0 1 1 1 1 Predicted membrane protein (DUF2177) DUF4017 PF13209.6 ELR17736.1 - 0.033 14.1 4.6 0.35 10.8 2.6 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF4017) IBR PF01485.21 ELR17737.1 - 1.7e-08 34.6 10.0 1.9e-08 34.4 2.2 2.7 3 0 0 3 3 3 2 IBR domain, a half RING-finger domain RCC1 PF00415.18 ELR17738.1 - 2.6e-67 223.2 19.5 2.4e-13 50.5 0.0 7.4 7 0 0 7 7 7 7 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 ELR17738.1 - 1.7e-41 139.2 33.0 3.2e-08 33.2 0.3 8.4 8 0 0 8 8 8 6 Regulator of chromosome condensation (RCC1) repeat BTB PF00651.31 ELR17738.1 - 4.5e-23 81.6 0.2 1.1e-12 48.2 0.0 2.7 2 0 0 2 2 2 2 BTB/POZ domain Chromo PF00385.24 ELR17738.1 - 1.5e-12 47.2 1.0 3e-12 46.2 0.1 2.0 2 0 0 2 2 2 1 Chromo (CHRromatin Organisation MOdifier) domain DUF1921 PF09081.10 ELR17738.1 - 0.011 16.0 0.5 21 5.4 0.0 3.8 4 0 0 4 4 4 0 Domain of unknown function (DUF1921) BACK PF07707.15 ELR17738.1 - 0.046 13.8 8.1 0.46 10.6 0.1 3.7 3 0 0 3 3 3 0 BTB And C-terminal Kelch RbpA PF13397.6 ELR17738.1 - 1.3 9.7 4.1 4.6 7.9 1.8 2.6 2 0 0 2 2 2 0 RNA polymerase-binding protein GATA PF00320.27 ELR17739.1 - 0.00048 19.7 0.3 0.001 18.6 0.3 1.6 1 0 0 1 1 1 1 GATA zinc finger GATA PF00320.27 ELR17740.1 - 1.2e-15 56.8 3.1 2e-15 56.1 3.1 1.4 1 0 0 1 1 1 1 GATA zinc finger zf-C2H2_11 PF16622.5 ELR17740.1 - 0.0045 16.7 2.3 0.12 12.1 0.2 2.5 2 0 0 2 2 2 1 zinc-finger C2H2-type zf-C2H2_3 PF13878.6 ELR17740.1 - 0.011 15.5 0.3 0.18 11.6 0.0 2.5 2 0 0 2 2 2 0 zinc-finger of acetyl-transferase ESCO Zn-ribbon_8 PF09723.10 ELR17740.1 - 0.022 14.9 1.4 0.022 14.9 0.2 1.6 2 0 0 2 2 2 0 Zinc ribbon domain DZR PF12773.7 ELR17740.1 - 0.74 9.9 4.2 0.83 9.7 2.5 1.8 1 1 1 2 2 2 0 Double zinc ribbon PknG_rubred PF16919.5 ELR17740.1 - 1.1 9.4 5.2 0.86 9.8 3.3 1.7 1 1 1 2 2 2 0 Protein kinase G rubredoxin domain zf-HYPF PF07503.12 ELR17740.1 - 1.4 8.7 4.1 21 5.0 0.1 2.6 3 0 0 3 3 3 0 HypF finger GATA PF00320.27 ELR17741.1 - 0.00046 19.7 0.3 0.00096 18.7 0.3 1.6 1 0 0 1 1 1 1 GATA zinc finger Suf PF05843.14 ELR17745.1 - 0.22 11.4 2.3 0.29 11.1 2.3 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) MCM_bind PF09739.9 ELR17745.1 - 0.96 7.8 3.8 1.2 7.5 3.8 1.1 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor Presenilin PF01080.17 ELR17745.1 - 1.6 7.4 4.0 1.9 7.2 4.0 1.1 1 0 0 1 1 1 0 Presenilin CDC45 PF02724.14 ELR17745.1 - 3.2 5.9 6.1 3.8 5.7 6.1 1.1 1 0 0 1 1 1 0 CDC45-like protein DTHCT PF08070.11 ELR17745.1 - 7.3 7.4 14.5 1.6 9.5 3.1 2.4 1 1 1 2 2 2 0 DTHCT (NUC029) region E1-E2_ATPase PF00122.20 ELR17746.1 - 1.3e-43 148.6 0.6 1.3e-43 148.6 0.6 2.2 3 0 0 3 3 3 1 E1-E2 ATPase Cation_ATPase_C PF00689.21 ELR17746.1 - 2.2e-37 128.5 1.2 2.2e-37 128.5 1.2 2.5 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus Cation_ATPase PF13246.6 ELR17746.1 - 7.1e-18 64.5 0.1 2.1e-17 63.0 0.1 1.9 1 1 0 1 1 1 1 Cation transport ATPase (P-type) Cation_ATPase_N PF00690.26 ELR17746.1 - 1.4e-15 56.7 0.0 6.2e-15 54.6 0.0 2.2 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase PF00702.26 ELR17746.1 - 3.6e-13 50.3 0.0 2.1e-12 47.8 0.0 2.2 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 ELR17746.1 - 0.057 13.1 0.6 0.12 12.1 0.6 1.5 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase Lipocalin_2 PF08212.12 ELR17746.1 - 0.14 12.1 0.1 0.26 11.2 0.1 1.4 1 0 0 1 1 1 0 Lipocalin-like domain RhoGAP PF00620.27 ELR17747.1 - 1.4e-19 70.4 0.3 5.5e-13 49.0 0.0 3.7 2 2 1 3 3 3 3 RhoGAP domain Cofilin_ADF PF00241.20 ELR17747.1 - 1.5e-08 34.4 0.0 5e-08 32.8 0.0 1.9 2 0 0 2 2 2 1 Cofilin/tropomyosin-type actin-binding protein BAR_3 PF16746.5 ELR17747.1 - 4.2e-06 26.6 10.7 4.2e-06 26.6 10.7 1.7 2 0 0 2 2 2 1 BAR domain of APPL family BAG6 PF12057.8 ELR17747.1 - 0.36 10.5 3.2 0.37 10.5 1.4 2.0 2 0 0 2 2 2 0 BCL2-associated athanogene 6 DSPc PF00782.20 ELR17748.1 - 1.2e-26 93.1 0.0 3.8e-20 72.0 0.0 2.5 2 0 0 2 2 2 2 Dual specificity phosphatase, catalytic domain Pkinase PF00069.25 ELR17751.1 - 1.2e-68 231.3 0.0 2e-68 230.6 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR17751.1 - 8.3e-51 172.7 0.0 1.2e-50 172.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase RIO1 PF01163.22 ELR17751.1 - 9.5e-05 22.1 0.1 0.00019 21.1 0.1 1.4 1 0 0 1 1 1 1 RIO1 family Pkinase_fungal PF17667.1 ELR17751.1 - 0.00022 20.1 0.0 0.00047 19.0 0.0 1.7 1 1 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 ELR17751.1 - 0.0013 18.1 0.1 0.007 15.7 0.0 1.9 1 1 0 2 2 2 1 Kinase-like APH PF01636.23 ELR17751.1 - 0.0028 17.6 1.5 0.0061 16.5 0.0 2.2 3 1 1 4 4 4 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 ELR17751.1 - 0.034 13.7 0.0 0.057 13.0 0.0 1.4 1 0 0 1 1 1 0 Choline/ethanolamine kinase GATA PF00320.27 ELR17752.1 - 7.2e-16 57.5 5.6 1.7e-15 56.3 5.6 1.7 1 0 0 1 1 1 1 GATA zinc finger DZR PF12773.7 ELR17752.1 - 0.11 12.5 1.1 0.24 11.5 1.1 1.5 1 0 0 1 1 1 0 Double zinc ribbon Ribosomal_S8 PF00410.19 ELR17753.1 - 1.8e-21 76.4 0.0 4e-21 75.3 0.0 1.5 1 1 0 1 1 1 1 Ribosomal protein S8 SH3BGR PF04908.15 ELR17754.1 - 2.7e-12 46.7 0.2 3.9e-12 46.2 0.2 1.2 1 0 0 1 1 1 1 SH3-binding, glutamic acid-rich protein Glutaredoxin PF00462.24 ELR17754.1 - 6e-08 32.8 0.1 1.4e-07 31.6 0.0 1.7 2 0 0 2 2 2 1 Glutaredoxin TruB_N PF01509.18 ELR17755.1 - 8e-20 71.7 0.0 1.2e-09 38.7 0.0 2.3 1 1 1 2 2 2 2 TruB family pseudouridylate synthase (N terminal domain) TruB_C_2 PF16198.5 ELR17755.1 - 0.0001 22.4 0.3 0.00079 19.5 0.1 2.2 2 0 0 2 2 2 1 tRNA pseudouridylate synthase B C-terminal domain cwf18 PF08315.12 ELR17755.1 - 0.62 10.7 7.1 0.6 10.8 5.9 1.6 2 0 0 2 2 2 0 cwf18 pre-mRNA splicing factor CDC45 PF02724.14 ELR17755.1 - 2.8 6.1 5.3 3.4 5.8 5.3 1.1 1 0 0 1 1 1 0 CDC45-like protein PI3_PI4_kinase PF00454.27 ELR17757.1 - 4.3e-54 183.9 0.1 3.2e-53 181.1 0.0 2.3 2 1 0 2 2 2 1 Phosphatidylinositol 3- and 4-kinase PH PF00169.29 ELR17757.1 - 8e-32 109.9 0.6 7.7e-15 55.3 0.2 2.6 2 0 0 2 2 2 2 PH domain PI3Ka PF00613.20 ELR17757.1 - 1e-28 100.0 2.5 1.2e-19 70.5 0.2 2.4 1 1 1 2 2 2 2 Phosphoinositide 3-kinase family, accessory domain (PIK domain) PI3K_rbd PF00794.18 ELR17757.1 - 3e-09 37.0 0.0 8e-09 35.6 0.0 1.8 1 0 0 1 1 1 1 PI3-kinase family, ras-binding domain PI3K_C2 PF00792.24 ELR17757.1 - 1.2e-08 34.9 0.0 2.5e-08 33.9 0.0 1.5 1 0 0 1 1 1 1 Phosphoinositide 3-kinase C2 PH_11 PF15413.6 ELR17757.1 - 3.7e-06 27.3 6.2 0.011 16.1 0.0 3.8 2 1 0 2 2 2 2 Pleckstrin homology domain PH_8 PF15409.6 ELR17757.1 - 1.2e-05 25.5 0.2 0.0038 17.5 0.1 2.8 2 1 0 2 2 2 1 Pleckstrin homology domain DUF4135 PF13575.6 ELR17757.1 - 0.01 15.2 0.0 0.017 14.4 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4135) PH_9 PF15410.6 ELR17757.1 - 0.04 14.3 0.4 1.3 9.4 0.1 3.1 3 0 0 3 3 3 0 Pleckstrin homology domain PH_2 PF08458.10 ELR17757.1 - 0.089 13.1 0.0 0.19 12.1 0.0 1.5 1 0 0 1 1 1 0 Plant pleckstrin homology-like region SRF-TF PF00319.18 ELR17758.1 - 2.5e-21 74.9 0.1 3.6e-21 74.4 0.1 1.2 1 0 0 1 1 1 1 SRF-type transcription factor (DNA-binding and dimerisation domain) PBP_like_2 PF12849.7 ELR17759.1 - 2.6e-07 30.6 1.1 2.8e-07 30.5 1.1 1.0 1 0 0 1 1 1 1 PBP superfamily domain MdcG PF10620.9 ELR17759.1 - 0.27 11.0 1.3 0.43 10.3 0.5 1.6 1 1 1 2 2 2 0 Phosphoribosyl-dephospho-CoA transferase MdcG Pkinase_Tyr PF07714.17 ELR17760.1 - 3.6e-124 413.2 0.0 8.9e-64 215.3 0.0 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 ELR17760.1 - 4e-110 367.3 0.0 6.2e-57 192.9 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Guanylate_cyc PF00211.20 ELR17760.1 - 2.7e-16 59.7 0.0 4.8e-16 58.9 0.0 1.4 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain PBP_like_2 PF12849.7 ELR17760.1 - 6.4e-12 45.7 2.9 1e-11 45.1 0.3 2.4 3 0 0 3 3 3 1 PBP superfamily domain APH PF01636.23 ELR17760.1 - 4.7e-07 30.0 0.8 0.00039 20.4 0.0 3.0 2 1 0 2 2 2 2 Phosphotransferase enzyme family EGF_2 PF07974.13 ELR17760.1 - 4.1e-05 23.9 9.1 7.8e-05 23.0 9.1 1.5 1 0 0 1 1 1 1 EGF-like domain Haspin_kinase PF12330.8 ELR17760.1 - 0.00021 20.4 0.0 0.016 14.2 0.0 2.2 2 0 0 2 2 2 1 Haspin like kinase domain FTA2 PF13095.6 ELR17760.1 - 0.00035 20.3 0.0 1.1 8.8 0.0 3.6 3 1 1 4 4 4 1 Kinetochore Sim4 complex subunit FTA2 Kdo PF06293.14 ELR17760.1 - 0.00041 19.8 0.3 0.22 10.8 0.1 2.4 2 0 0 2 2 2 2 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 ELR17760.1 - 0.0011 18.3 0.0 0.33 10.2 0.0 2.5 2 0 0 2 2 2 2 Kinase-like I-EGF_1 PF18372.1 ELR17760.1 - 0.0026 17.8 5.4 0.0052 16.9 5.4 1.5 1 0 0 1 1 1 1 Integrin beta epidermal growth factor like domain 1 RIO1 PF01163.22 ELR17760.1 - 0.0052 16.4 0.8 3.1 7.3 0.1 2.4 2 0 0 2 2 2 2 RIO1 family EGF PF00008.27 ELR17760.1 - 0.16 12.3 2.0 0.33 11.3 2.0 1.5 1 0 0 1 1 1 0 EGF-like domain EGF_Tenascin PF18720.1 ELR17760.1 - 0.17 12.0 8.9 0.11 12.6 6.1 2.2 2 0 0 2 2 2 0 Tenascin EGF domain EB PF01683.18 ELR17760.1 - 1.7 9.0 8.4 3.7 7.9 8.4 1.5 1 0 0 1 1 1 0 EB module Serpin PF00079.20 ELR17761.1 - 2.7e-90 303.4 0.0 3e-90 303.2 0.0 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) B_lectin PF01453.24 ELR17761.1 - 0.026 15.0 0.1 0.05 14.2 0.1 1.4 1 0 0 1 1 1 0 D-mannose binding lectin PTCB-BRCT PF12738.7 ELR17762.1 - 5.4e-29 99.9 2.2 2.2e-12 46.7 0.0 6.1 6 0 0 6 6 6 3 twin BRCT domain BRCT PF00533.26 ELR17762.1 - 4.4e-24 84.6 0.0 4e-06 27.1 0.0 5.3 6 0 0 6 6 6 3 BRCA1 C Terminus (BRCT) domain GATA PF00320.27 ELR17762.1 - 2.3e-13 49.5 4.4 6.3e-13 48.1 4.4 1.8 1 0 0 1 1 1 1 GATA zinc finger BRCT_2 PF16589.5 ELR17762.1 - 1e-08 35.5 0.0 0.0095 16.3 0.0 5.1 5 0 0 5 5 5 2 BRCT domain, a BRCA1 C-terminus domain LIG3_BRCT PF16759.5 ELR17762.1 - 1.3e-08 35.0 1.7 0.28 11.5 0.0 5.5 4 1 0 4 4 4 2 DNA ligase 3 BRCT domain RTT107_BRCT_5 PF16770.5 ELR17762.1 - 0.0015 18.3 0.6 0.024 14.5 0.0 3.1 4 0 0 4 4 4 1 Regulator of Ty1 transposition protein 107 BRCT domain BRCT_3 PF18428.1 ELR17762.1 - 0.062 13.4 0.1 2.2 8.4 0.1 3.2 4 0 0 4 4 4 0 BRCA1 C Terminus (BRCT) domain OrfB_Zn_ribbon PF07282.11 ELR17762.1 - 0.63 10.0 3.4 2.2 8.3 3.4 1.9 1 0 0 1 1 1 0 Putative transposase DNA-binding domain SPT16 PF08644.11 ELR17762.1 - 2.5 8.3 7.2 6.6 6.9 4.4 2.7 2 0 0 2 2 2 0 FACT complex subunit (SPT16/CDC68) Nudix_N_2 PF14803.6 ELR17762.1 - 3 7.8 5.2 9.2 6.3 5.2 1.9 1 0 0 1 1 1 0 Nudix N-terminal PH PF00169.29 ELR17763.1 - 1.3e-09 38.5 0.7 2.3e-09 37.7 0.1 1.7 2 0 0 2 2 2 1 PH domain PH_11 PF15413.6 ELR17763.1 - 0.0068 16.8 1.6 0.0068 16.8 1.6 2.1 2 1 0 2 2 2 1 Pleckstrin homology domain ECH_1 PF00378.20 ELR17764.1 - 7.2e-35 120.5 0.0 8.6e-35 120.2 0.0 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 ELR17764.1 - 4.9e-10 39.4 0.0 5.1e-09 36.1 0.0 1.8 1 1 1 2 2 2 1 Enoyl-CoA hydratase/isomerase AAA PF00004.29 ELR17765.1 - 1.8e-13 51.1 0.1 5.7e-13 49.4 0.1 1.9 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 ELR17765.1 - 1.3e-05 25.0 0.0 2.6e-05 24.0 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 ELR17765.1 - 1.6e-05 25.2 0.0 0.00059 20.1 0.0 3.0 1 1 0 1 1 1 1 AAA domain AAA_14 PF13173.6 ELR17765.1 - 1.6e-05 25.0 0.0 4e-05 23.7 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 ELR17765.1 - 0.00015 22.2 0.0 0.00097 19.6 0.0 2.2 1 1 0 1 1 1 1 AAA ATPase domain AAA_5 PF07728.14 ELR17765.1 - 0.00015 21.8 0.0 0.00047 20.2 0.0 1.9 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) Rad17 PF03215.15 ELR17765.1 - 0.00027 20.9 0.3 0.033 14.1 0.0 2.5 2 0 0 2 2 2 1 Rad17 P-loop domain IstB_IS21 PF01695.17 ELR17765.1 - 0.00046 20.0 0.0 0.001 18.8 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein Zeta_toxin PF06414.12 ELR17765.1 - 0.0037 16.6 0.0 0.0083 15.4 0.0 1.5 1 0 0 1 1 1 1 Zeta toxin AAA_24 PF13479.6 ELR17765.1 - 0.0044 16.8 0.1 0.0094 15.7 0.1 1.6 1 0 0 1 1 1 1 AAA domain Sfi1_C PF10638.9 ELR17765.1 - 0.0045 17.7 0.4 0.015 16.0 0.4 1.9 1 0 0 1 1 1 1 Spindle body associated protein C-terminus NACHT PF05729.12 ELR17765.1 - 0.0075 16.2 0.1 0.051 13.5 0.1 2.5 1 1 0 1 1 1 1 NACHT domain AAA_33 PF13671.6 ELR17765.1 - 0.0094 16.1 0.0 0.027 14.6 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 ELR17765.1 - 0.01 16.4 0.1 0.042 14.4 0.0 2.1 2 0 0 2 2 1 0 AAA domain NTPase_1 PF03266.15 ELR17765.1 - 0.012 15.5 0.2 0.031 14.2 0.1 1.8 2 0 0 2 2 1 0 NTPase TsaE PF02367.17 ELR17765.1 - 0.021 14.8 0.0 0.046 13.7 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Sigma54_activ_2 PF14532.6 ELR17765.1 - 0.022 14.9 0.0 0.057 13.5 0.0 1.7 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_25 PF13481.6 ELR17765.1 - 0.035 13.7 0.0 0.098 12.2 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_assoc_2 PF16193.5 ELR17765.1 - 0.039 14.3 0.3 0.2 12.0 0.1 2.3 2 0 0 2 2 2 0 AAA C-terminal domain AAA_28 PF13521.6 ELR17765.1 - 0.043 14.1 0.0 0.36 11.1 0.0 2.5 2 0 0 2 2 2 0 AAA domain AAA_30 PF13604.6 ELR17765.1 - 0.055 13.2 0.1 0.16 11.7 0.1 1.7 1 0 0 1 1 1 0 AAA domain ATPase PF06745.13 ELR17765.1 - 0.1 11.9 0.0 1.2 8.5 0.0 2.2 1 1 1 2 2 2 0 KaiC AAA_19 PF13245.6 ELR17765.1 - 0.11 12.9 0.0 0.35 11.2 0.0 1.9 1 0 0 1 1 1 0 AAA domain TniB PF05621.11 ELR17765.1 - 0.12 11.7 0.0 5.1 6.5 0.0 2.3 1 1 1 2 2 2 0 Bacterial TniB protein ABC_tran PF00005.27 ELR17765.1 - 0.12 12.8 0.0 0.52 10.8 0.0 2.1 1 0 0 1 1 1 0 ABC transporter RNA_helicase PF00910.22 ELR17765.1 - 0.16 12.4 0.0 0.44 11.0 0.0 1.8 1 0 0 1 1 1 0 RNA helicase FoP_duplication PF13865.6 ELR17765.1 - 5.1 7.7 14.5 1.1 9.8 3.8 2.8 2 0 0 2 2 2 0 C-terminal duplication domain of Friend of PRMT1 SDA1 PF05285.12 ELR17766.1 - 0.00039 20.0 6.5 0.0005 19.6 6.5 1.1 1 0 0 1 1 1 1 SDA1 zf-His_Me_endon PF05551.11 ELR17766.1 - 0.0098 16.1 2.1 0.022 15.0 2.1 1.6 1 0 0 1 1 1 1 Zinc-binding loop region of homing endonuclease BUD22 PF09073.10 ELR17766.1 - 0.2 11.0 11.5 0.28 10.5 11.5 1.2 1 0 0 1 1 1 0 BUD22 Nop14 PF04147.12 ELR17766.1 - 0.55 8.4 12.7 0.72 8.0 12.7 1.1 1 0 0 1 1 1 0 Nop14-like family Voldacs PF03517.13 ELR17766.1 - 6.8 6.8 9.2 12 6.1 9.2 1.2 1 0 0 1 1 1 0 Regulator of volume decrease after cellular swelling LRR_4 PF12799.7 ELR17767.1 - 7.5e-05 23.0 11.7 35 5.0 0.0 8.5 6 2 1 7 7 7 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 ELR17767.1 - 0.00033 20.3 5.0 2.7 7.8 0.0 7.4 9 1 1 10 10 10 1 Leucine rich repeat LRR_6 PF13516.6 ELR17767.1 - 0.61 10.3 18.7 1.5 9.1 0.1 8.2 10 0 0 10 10 10 0 Leucine Rich repeat Beta-lactamase PF00144.24 ELR17768.1 - 1.2e-29 103.6 1.8 1.7e-29 103.2 1.8 1.2 1 0 0 1 1 1 1 Beta-lactamase Inositol_P PF00459.25 ELR17769.1 - 1.5e-66 224.7 0.1 1.7e-66 224.5 0.1 1.0 1 0 0 1 1 1 1 Inositol monophosphatase family PSI PF01437.25 ELR17770.1 - 0.00086 19.8 7.3 0.0015 19.0 7.3 1.4 1 0 0 1 1 1 1 Plexin repeat Pkinase_Tyr PF07714.17 ELR17771.1 - 5.7e-79 265.0 0.0 1.5e-78 263.7 0.0 1.7 2 0 0 2 2 2 1 Protein tyrosine kinase RCC1 PF00415.18 ELR17771.1 - 5e-55 183.9 18.0 5e-11 43.1 0.0 6.7 6 0 0 6 6 6 6 Regulator of chromosome condensation (RCC1) repeat Pkinase PF00069.25 ELR17771.1 - 7.5e-42 143.5 0.0 1.6e-41 142.5 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain RCC1_2 PF13540.6 ELR17771.1 - 9.6e-26 89.0 20.1 3.1e-06 26.8 0.0 7.5 8 0 0 8 8 8 5 Regulator of chromosome condensation (RCC1) repeat Kdo PF06293.14 ELR17771.1 - 0.025 13.9 0.1 0.043 13.2 0.1 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 ELR17771.1 - 0.21 11.5 0.1 1.9 8.3 0.2 2.1 1 1 1 2 2 2 0 Phosphotransferase enzyme family SRP-alpha_N PF04086.13 ELR17771.1 - 0.22 11.4 37.4 0.19 11.6 17.6 2.2 2 0 0 2 2 2 0 Signal recognition particle, alpha subunit, N-terminal Vfa1 PF08432.10 ELR17771.1 - 6.7 7.0 42.2 0.91 9.8 16.6 2.5 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 p450 PF00067.22 ELR17772.1 - 3.9e-38 131.4 0.0 6.5e-36 124.1 0.0 2.0 2 0 0 2 2 2 2 Cytochrome P450 MMS19_C PF12460.8 ELR17773.1 - 2.9e-85 287.0 0.1 2.9e-85 287.0 0.1 2.6 2 0 0 2 2 2 1 RNAPII transcription regulator C-terminal MMS19_N PF14500.6 ELR17773.1 - 2.6e-76 256.7 5.7 2.8e-76 256.6 0.4 3.4 3 0 0 3 3 3 1 Dos2-interacting transcription regulator of RNA-Pol-II HEAT PF02985.22 ELR17773.1 - 0.00037 20.5 9.2 2.3 8.7 0.1 6.2 5 0 0 5 5 5 1 HEAT repeat ParcG PF10274.9 ELR17773.1 - 0.0017 18.5 0.8 0.0071 16.5 0.2 2.3 2 0 0 2 2 2 1 Parkin co-regulated protein HEAT_EZ PF13513.6 ELR17773.1 - 0.0026 18.2 14.5 0.29 11.7 0.0 7.0 9 0 0 9 9 9 1 HEAT-like repeat IFRD PF05004.13 ELR17773.1 - 0.012 14.8 5.9 0.013 14.6 0.0 3.7 5 1 1 6 6 6 0 Interferon-related developmental regulator (IFRD) HEAT_2 PF13646.6 ELR17773.1 - 0.012 15.9 13.9 0.24 11.8 0.0 5.5 7 0 0 7 7 7 0 HEAT repeats Cnd1 PF12717.7 ELR17773.1 - 0.039 14.0 4.1 12 6.0 0.1 4.3 4 2 0 4 4 4 0 non-SMC mitotic condensation complex subunit 1 FANCI_S2 PF14676.6 ELR17773.1 - 0.069 13.4 4.8 0.07 13.4 0.3 2.9 3 0 0 3 3 3 0 FANCI solenoid 2 Telomere_reg-2 PF10193.9 ELR17773.1 - 0.18 12.3 5.1 16 6.0 0.0 4.9 6 1 0 6 6 4 0 Telomere length regulation protein SelP_N PF04592.14 ELR17773.1 - 5.3 6.4 6.4 9.4 5.6 6.4 1.4 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Adaptin_N PF01602.20 ELR17773.1 - 9.7 4.6 8.1 4.2 5.8 0.3 3.6 4 1 0 4 4 4 0 Adaptin N terminal region EF-hand_7 PF13499.6 ELR17774.1 - 8.6e-13 48.5 0.0 6.5e-09 36.1 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 ELR17774.1 - 1.3e-10 40.4 0.1 0.00043 20.0 0.0 3.8 3 0 0 3 3 3 2 EF-hand domain EF-hand_1 PF00036.32 ELR17774.1 - 2.6e-10 39.1 0.0 0.0041 16.6 0.0 3.7 4 0 0 4 4 4 3 EF hand EF-hand_8 PF13833.6 ELR17774.1 - 2.7e-09 36.7 0.0 2.1e-05 24.3 0.0 3.9 2 2 2 4 4 4 2 EF-hand domain pair EF-hand_5 PF13202.6 ELR17774.1 - 1.6e-08 33.6 0.2 0.00049 19.5 0.0 3.3 3 0 0 3 3 3 2 EF hand Wzt_C PF14524.6 ELR17775.1 - 0.054 13.5 0.0 0.19 11.7 0.0 1.9 2 0 0 2 2 2 0 Wzt C-terminal domain DUF4690 PF15756.5 ELR17775.1 - 0.2 12.3 2.2 0.47 11.1 2.2 1.6 1 0 0 1 1 1 0 Small Novel Rich in Cartilage Usp PF00582.26 ELR17776.1 - 1.7e-24 86.9 0.2 1.9e-24 86.7 0.2 1.0 1 0 0 1 1 1 1 Universal stress protein family WD40 PF00400.32 ELR17777.1 - 3.7e-42 141.5 18.0 6.7e-07 29.9 0.0 11.4 11 0 0 11 11 11 7 WD domain, G-beta repeat Utp12 PF04003.12 ELR17777.1 - 2.7e-22 79.1 0.1 4.3e-22 78.5 0.1 1.3 1 0 0 1 1 1 1 Dip2/Utp12 Family ANAPC4_WD40 PF12894.7 ELR17777.1 - 5.9e-20 71.4 0.0 0.055 13.8 0.0 9.4 3 2 5 9 9 9 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ELR17777.1 - 1.7e-08 33.8 0.0 0.064 12.2 0.0 4.6 3 2 1 5 5 5 3 WD40 region of Ge1, enhancer of mRNA-decapping protein RAB3GAP2_N PF14655.6 ELR17777.1 - 0.014 14.7 0.0 7 5.8 0.0 3.0 2 1 0 3 3 3 0 Rab3 GTPase-activating protein regulatory subunit N-terminus PD40 PF07676.12 ELR17777.1 - 0.095 12.7 3.3 21 5.2 0.1 4.8 6 0 0 6 6 6 0 WD40-like Beta Propeller Repeat Thg1C PF14413.6 ELR17777.1 - 0.16 12.1 0.3 0.33 11.1 0.3 1.5 1 0 0 1 1 1 0 Thg1 C terminal domain Hid1 PF12722.7 ELR17777.1 - 0.25 9.4 0.2 0.36 8.9 0.2 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein PMT_2 PF13231.6 ELR17778.1 - 0.0044 17.2 4.2 0.0044 17.2 4.2 2.0 2 0 0 2 2 2 1 Dolichyl-phosphate-mannose-protein mannosyltransferase MARVEL PF01284.23 ELR17778.1 - 0.086 12.9 14.2 0.26 11.3 14.2 1.8 1 1 0 1 1 1 0 Membrane-associating domain PsbN PF02468.15 ELR17778.1 - 7 6.6 6.2 7.3 6.5 0.5 2.5 2 0 0 2 2 2 0 Photosystem II reaction centre N protein (psbN) P34-Arc PF04045.14 ELR17779.1 - 3.7e-77 259.3 0.0 4.9e-77 258.9 0.0 1.1 1 0 0 1 1 1 1 Arp2/3 complex, 34 kD subunit p34-Arc NTF2 PF02136.20 ELR17780.1 - 9.9e-29 100.4 0.1 1.2e-28 100.1 0.1 1.1 1 0 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain CBS PF00571.28 ELR17781.1 - 3.3e-29 101.1 2.1 2.3e-11 43.9 0.1 4.7 5 0 0 5 5 5 4 CBS domain IF3_N PF05198.16 ELR17781.1 - 0.091 13.0 0.1 7.4 6.9 0.0 3.1 3 0 0 3 3 3 0 Translation initiation factor IF-3, N-terminal domain FlaF PF07309.11 ELR17783.1 - 0.81 9.7 4.0 29 4.7 1.7 2.9 3 0 0 3 3 3 0 Flagellar protein FlaF CDC45 PF02724.14 ELR17783.1 - 1.4 7.2 20.7 0.14 10.4 12.4 2.3 2 0 0 2 2 2 0 CDC45-like protein HEAT PF02985.22 ELR17783.1 - 2.1 8.8 4.5 3.9 8.0 0.0 3.4 4 0 0 4 4 4 0 HEAT repeat DUF3712 PF12505.8 ELR17784.1 - 2e-34 118.6 12.4 8.3e-18 64.8 0.2 4.1 5 0 0 5 5 5 3 Protein of unknown function (DUF3712) LEA_2 PF03168.13 ELR17784.1 - 0.0007 20.1 5.0 15 6.2 0.0 6.0 6 0 0 6 6 6 2 Late embryogenesis abundant protein Tk-SP_N-pro PF18237.1 ELR17784.1 - 0.15 12.1 0.0 0.35 11.0 0.0 1.5 1 0 0 1 1 1 0 Tk-SP N-propeptide domain Thiolase_N PF00108.23 ELR17785.1 - 1.1e-79 267.5 1.7 1.1e-79 267.5 1.7 1.9 2 0 0 2 2 2 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 ELR17785.1 - 9.2e-49 164.2 0.7 1.7e-48 163.4 0.7 1.4 1 0 0 1 1 1 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.26 ELR17785.1 - 0.00026 20.6 1.7 0.00056 19.6 0.8 1.9 1 1 1 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain ACP_syn_III PF08545.10 ELR17785.1 - 0.0045 16.8 0.4 1.3 8.9 0.1 2.8 2 0 0 2 2 2 2 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III PARP_reg PF02877.14 ELR17788.1 - 6.6e-13 48.9 0.0 1.1e-12 48.2 0.0 1.4 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase, regulatory domain WWE PF02825.20 ELR17788.1 - 3.5e-10 40.3 2.5 7.6e-10 39.2 2.5 1.6 1 0 0 1 1 1 1 WWE domain OrsD PF12013.8 ELR17788.1 - 0.049 14.1 0.9 0.049 14.1 0.9 1.8 3 0 0 3 3 3 0 Orsellinic acid/F9775 biosynthesis cluster protein D DUF4554 PF15091.6 ELR17788.1 - 0.056 12.3 0.2 0.092 11.6 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4554) PilJ PF13675.6 ELR17788.1 - 0.093 12.8 3.2 7.8 6.6 0.0 3.1 2 1 2 4 4 4 0 Type IV pili methyl-accepting chemotaxis transducer N-term ArfGap PF01412.18 ELR17789.1 - 2.4e-08 34.1 0.4 9.4e-08 32.1 0.1 2.2 2 0 0 2 2 2 1 Putative GTPase activating protein for Arf CAP PF00188.26 ELR17790.1 - 0.0041 18.0 0.0 0.0069 17.2 0.0 1.4 1 0 0 1 1 1 1 Cysteine-rich secretory protein family Olduvai PF06758.13 ELR17790.1 - 0.018 15.3 1.0 0.039 14.2 1.0 1.5 1 0 0 1 1 1 0 Olduvai domain ProRS-C_1 PF09180.11 ELR17791.1 - 1e-22 80.1 1.1 3e-21 75.4 0.1 3.1 2 1 0 2 2 2 1 Prolyl-tRNA synthetase, C-terminal tRNA-synt_2b PF00587.25 ELR17791.1 - 3.9e-17 62.8 0.1 1.8e-16 60.6 0.0 2.1 3 0 0 3 3 3 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.20 ELR17791.1 - 1.1e-16 60.8 0.2 1.2e-15 57.4 0.0 2.8 2 0 0 2 2 2 1 Anticodon binding domain Fib_alpha PF08702.10 ELR17791.1 - 3.5 7.8 9.2 16 5.7 0.4 2.5 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family DASH_Dad2 PF08654.10 ELR17791.1 - 4 7.9 15.5 0.7 10.3 9.2 2.9 3 1 1 4 4 4 0 DASH complex subunit Dad2 FlxA PF14282.6 ELR17791.1 - 7 6.7 23.9 0.083 12.9 1.9 2.8 2 1 0 2 2 2 0 FlxA-like protein FAM76 PF16046.5 ELR17791.1 - 9.9 5.4 21.7 0.97 8.7 3.7 2.2 2 0 0 2 2 2 0 FAM76 protein Profilin PF00235.19 ELR17792.1 - 1.8e-47 160.7 0.6 2e-47 160.6 0.6 1.0 1 0 0 1 1 1 1 Profilin Clat_adaptor_s PF01217.20 ELR17793.1 - 3.3e-49 166.5 0.4 3.9e-49 166.3 0.4 1.0 1 0 0 1 1 1 1 Clathrin adaptor complex small chain Myosin_head PF00063.21 ELR17794.1 - 2.7e-238 792.6 0.0 4.1e-238 792.0 0.0 1.3 1 0 0 1 1 1 1 Myosin head (motor domain) MyTH4 PF00784.17 ELR17794.1 - 4.5e-53 178.3 0.0 1.1e-24 87.0 0.0 3.7 3 0 0 3 3 3 2 MyTH4 domain FERM_M PF00373.18 ELR17794.1 - 3.9e-34 117.6 0.0 2.5e-20 73.0 0.0 3.3 2 0 0 2 2 2 2 FERM central domain SH3_9 PF14604.6 ELR17794.1 - 1.7e-11 43.8 0.1 5.8e-10 38.9 0.1 2.9 2 0 0 2 2 2 1 Variant SH3 domain IQ PF00612.27 ELR17794.1 - 4e-10 38.6 27.6 0.019 14.7 5.0 4.8 4 0 0 4 4 4 4 IQ calmodulin-binding motif FERM_N PF09379.10 ELR17794.1 - 5e-09 36.0 0.0 3.3e-05 23.8 0.0 2.9 2 0 0 2 2 2 2 FERM N-terminal domain SH3_1 PF00018.28 ELR17794.1 - 1.9e-08 33.8 0.3 4.3e-08 32.6 0.3 1.7 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 ELR17794.1 - 4.8e-08 32.6 0.0 1e-07 31.5 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain RA PF00788.23 ELR17794.1 - 1.8e-07 31.7 0.0 0.0017 19.0 0.0 2.8 2 0 0 2 2 2 2 Ras association (RalGDS/AF-6) domain AAA_lid_6 PF17866.1 ELR17794.1 - 0.04 14.1 0.9 59 3.9 0.0 4.0 4 0 0 4 4 3 0 AAA lid domain AAA_16 PF13191.6 ELR17794.1 - 0.046 14.1 0.8 0.45 10.9 0.0 2.8 2 0 0 2 2 2 0 AAA ATPase domain TsaE PF02367.17 ELR17794.1 - 0.1 12.6 0.0 0.38 10.8 0.0 1.9 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE IML1 PF12257.8 ELR17794.1 - 0.78 8.8 5.8 1.5 7.9 5.8 1.4 1 0 0 1 1 1 0 Vacuolar membrane-associated protein Iml1 Vps39_2 PF10367.9 ELR17795.1 - 0.019 15.4 0.1 0.039 14.4 0.1 1.5 1 0 0 1 1 1 0 Vacuolar sorting protein 39 domain 2 Ima1_N PF09779.9 ELR17795.1 - 0.02 15.7 0.5 0.028 15.3 0.5 1.3 1 0 0 1 1 1 0 Ima1 N-terminal domain Endonuclease_7 PF02945.15 ELR17795.1 - 0.15 12.0 3.1 3.5 7.6 2.7 2.2 2 0 0 2 2 2 0 Recombination endonuclease VII Peptidase_M64 PF09471.10 ELR17795.1 - 0.18 11.3 0.1 0.28 10.7 0.1 1.3 1 0 0 1 1 1 0 IgA Peptidase M64 Actin_micro PF17003.5 ELR17795.1 - 0.37 9.9 0.3 0.69 9.0 0.2 1.6 1 1 1 2 2 2 0 Putative actin-like family G8 PF10162.9 ELR17796.1 - 3e-21 75.7 0.0 5.9e-21 74.8 0.0 1.5 1 0 0 1 1 1 1 G8 domain Ribonuc_red_sm PF00268.21 ELR17798.1 - 3.7e-06 26.6 0.0 5.3e-06 26.1 0.0 1.2 1 0 0 1 1 1 1 Ribonucleotide reductase, small chain Ribonuc_red_sm PF00268.21 ELR17799.1 - 3.1e-48 164.7 0.0 3.7e-48 164.4 0.0 1.0 1 0 0 1 1 1 1 Ribonucleotide reductase, small chain RNA_pol_Rpb2_2 PF04561.14 ELR17800.1 - 3.3 7.3 4.3 5.2 6.6 4.3 1.2 1 0 0 1 1 1 0 RNA polymerase Rpb2, domain 2 Rho_N PF07498.12 ELR17802.1 - 5.5e-10 39.0 0.5 6.3e-08 32.4 0.0 3.2 3 0 0 3 3 3 1 Rho termination factor, N-terminal domain FANC_SAP PF18081.1 ELR17802.1 - 0.095 12.9 0.2 0.3 11.3 0.2 1.9 1 0 0 1 1 1 0 Fanconi anemia-associated nuclease SAP domain Rho_N PF07498.12 ELR17803.1 - 1.8e-11 43.8 4.6 5.6e-09 35.8 0.2 2.4 2 0 0 2 2 2 2 Rho termination factor, N-terminal domain HeH PF12949.7 ELR17803.1 - 0.002 17.8 3.9 0.018 14.7 0.2 3.5 4 0 0 4 4 4 1 HeH/LEM domain SAP PF02037.27 ELR17803.1 - 0.043 13.6 1.2 6.5 6.6 0.0 3.5 4 0 0 4 4 4 0 SAP domain FANC_SAP PF18081.1 ELR17803.1 - 1.7 8.9 7.8 1.2 9.4 2.9 3.2 3 1 0 3 3 3 0 Fanconi anemia-associated nuclease SAP domain PAN_4 PF14295.6 ELR17804.1 - 3.7e-08 33.2 2.8 5.6e-08 32.6 2.8 1.3 1 0 0 1 1 1 1 PAN domain MLANA PF14991.6 ELR17804.1 - 0.008 16.5 0.0 0.0099 16.1 0.0 1.2 1 0 0 1 1 1 1 Protein melan-A DUF565 PF04483.12 ELR17805.1 - 0.027 15.0 0.1 0.044 14.3 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF565) PKD PF00801.20 ELR17805.1 - 0.23 11.3 0.1 0.23 11.3 0.1 3.0 3 1 0 3 3 3 0 PKD domain PKD PF00801.20 ELR17806.1 - 3.6e-05 23.5 5.4 0.17 11.7 0.1 3.8 3 1 0 3 3 3 2 PKD domain MspA PF09203.11 ELR17806.1 - 0.0015 18.4 2.1 0.0022 17.9 1.1 1.9 1 1 0 1 1 1 1 MspA Y_Y_Y PF07495.13 ELR17806.1 - 0.013 15.4 0.1 18 5.3 0.0 3.2 3 0 0 3 3 3 0 Y_Y_Y domain SusE PF14292.6 ELR17806.1 - 0.034 14.4 0.1 0.034 14.4 0.1 2.8 1 1 0 3 3 3 0 SusE outer membrane protein FlgD_ig PF13860.6 ELR17806.1 - 0.71 9.8 3.4 21 5.1 0.0 3.8 4 0 0 4 4 4 0 FlgD Ig-like domain Peptidase_C1 PF00112.23 ELR17807.1 - 1.1e-61 208.7 2.5 9.5e-61 205.7 2.5 2.0 1 1 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.12 ELR17807.1 - 5.8e-15 55.5 7.2 9.9e-15 54.7 7.2 1.4 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) TFIIS_C PF01096.18 ELR17808.1 - 3.3e-10 39.6 7.7 7.7e-10 38.5 7.7 1.7 1 0 0 1 1 1 1 Transcription factor S-II (TFIIS) TFIIS_M PF07500.14 ELR17808.1 - 1.3e-09 38.5 0.0 1.8e-09 38.1 0.0 1.3 1 0 0 1 1 1 1 Transcription factor S-II (TFIIS), central domain Metallophos PF00149.28 ELR17812.1 - 2.4e-16 60.8 2.6 3.7e-16 60.2 2.6 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Pur_ac_phosph_N PF16656.5 ELR17812.1 - 9.5e-10 38.9 0.0 1.9e-09 38.0 0.0 1.5 1 0 0 1 1 1 1 Purple acid Phosphatase, N-terminal domain Metallophos_2 PF12850.7 ELR17812.1 - 3.4e-07 30.6 0.1 1.7e-06 28.3 0.1 2.0 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain PhoD PF09423.10 ELR17812.1 - 0.031 13.3 0.8 0.083 11.9 0.1 2.0 2 1 0 2 2 2 0 PhoD-like phosphatase IMPDH PF00478.25 ELR17813.1 - 8.2e-84 281.5 0.0 1.3e-41 142.8 0.0 2.0 1 1 1 2 2 2 2 IMP dehydrogenase / GMP reductase domain CBS PF00571.28 ELR17813.1 - 1.7e-14 54.0 1.0 3e-06 27.6 0.1 2.8 2 0 0 2 2 2 2 CBS domain Aldolase PF01081.19 ELR17813.1 - 0.003 17.0 0.5 0.0063 16.0 0.5 1.5 1 0 0 1 1 1 1 KDPG and KHG aldolase FMN_dh PF01070.18 ELR17813.1 - 0.24 10.4 2.7 7 5.6 2.5 2.4 1 1 1 2 2 2 0 FMN-dependent dehydrogenase RCC1 PF00415.18 ELR17814.1 - 6.1e-10 39.6 0.1 9.2e-10 39.0 0.1 1.3 1 0 0 1 1 1 1 Regulator of chromosome condensation (RCC1) repeat LRR_8 PF13855.6 ELR17815.1 - 1e-06 28.4 0.4 1.8e-06 27.6 0.4 1.4 1 0 0 1 1 1 1 Leucine rich repeat LRR_4 PF12799.7 ELR17815.1 - 0.0073 16.7 1.3 0.22 12.0 1.3 2.4 1 1 2 3 3 3 2 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 ELR17815.1 - 0.011 16.1 0.4 14 6.7 0.0 3.1 2 0 0 2 2 2 0 Leucine Rich Repeat Nudix_N_2 PF14803.6 ELR17815.1 - 0.059 13.3 0.7 0.14 12.1 0.1 2.0 2 0 0 2 2 2 0 Nudix N-terminal LRR_6 PF13516.6 ELR17815.1 - 0.32 11.2 1.1 20 5.5 0.2 2.7 2 0 0 2 2 2 0 Leucine Rich repeat PAE PF03283.13 ELR17816.1 - 1.1e-64 218.8 1.5 1.8e-64 218.1 1.5 1.3 1 0 0 1 1 1 1 Pectinacetylesterase Yip1 PF04893.17 ELR17817.1 - 6e-08 32.6 12.3 9.5e-08 31.9 12.3 1.3 1 0 0 1 1 1 1 Yip1 domain YIF1 PF03878.15 ELR17817.1 - 4.5e-07 29.6 5.6 4e-05 23.2 5.5 2.1 1 1 0 1 1 1 1 YIF1 WD40 PF00400.32 ELR17818.1 - 5.4e-45 150.5 19.3 8.8e-07 29.5 0.9 7.3 6 1 1 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ELR17818.1 - 2e-16 60.1 0.7 0.0087 16.3 0.0 5.9 2 1 4 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ELR17818.1 - 0.00013 20.7 0.1 0.77 8.3 0.1 3.4 1 1 1 2 2 2 2 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 ELR17818.1 - 0.0017 17.4 1.9 4.5 6.1 0.0 4.7 3 1 2 5 5 5 1 WD40 region of Ge1, enhancer of mRNA-decapping protein Glyco_hyd_65N_2 PF14498.6 ELR17818.1 - 0.045 13.6 0.6 0.11 12.3 0.2 1.7 2 0 0 2 2 2 0 Glycosyl hydrolase family 65, N-terminal domain PYC_OADA PF02436.18 ELR17818.1 - 0.11 12.3 0.3 0.2 11.4 0.3 1.4 1 0 0 1 1 1 0 Conserved carboxylase domain PALB2_WD40 PF16756.5 ELR17818.1 - 0.15 10.9 3.1 3 6.7 0.0 3.0 3 0 0 3 3 3 0 Partner and localizer of BRCA2 WD40 domain DUF3330 PF11809.8 ELR17820.1 - 0.11 12.5 1.2 1 9.5 0.0 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF3330) PIF1 PF05970.14 ELR17822.1 - 1.1e-33 116.9 0.1 2e-33 116.1 0.1 1.4 1 0 0 1 1 1 1 PIF1-like helicase AAA_30 PF13604.6 ELR17822.1 - 3.6e-13 49.7 0.1 5.2e-12 45.9 0.0 2.3 1 1 1 2 2 2 1 AAA domain AAA_19 PF13245.6 ELR17822.1 - 5.5e-09 36.5 0.2 3.6e-08 33.9 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 ELR17822.1 - 1.3e-06 28.7 0.0 4.8e-06 26.9 0.0 1.9 1 0 0 1 1 1 1 AAA domain CUE PF02845.16 ELR17822.1 - 1.6e-05 24.5 0.0 3.4e-05 23.4 0.0 1.5 1 0 0 1 1 1 1 CUE domain AAA PF00004.29 ELR17822.1 - 8.9e-05 22.9 0.1 0.0003 21.2 0.1 1.9 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) AAA_24 PF13479.6 ELR17822.1 - 0.0009 19.0 0.1 0.0029 17.4 0.0 1.8 2 0 0 2 2 2 1 AAA domain Caldesmon PF02029.15 ELR17822.1 - 0.001 18.0 15.2 0.0012 17.7 15.2 1.2 1 0 0 1 1 1 1 Caldesmon AAA_16 PF13191.6 ELR17822.1 - 0.0027 18.1 0.5 0.0074 16.7 0.0 1.9 2 0 0 2 2 2 1 AAA ATPase domain Mg_chelatase PF01078.21 ELR17822.1 - 0.0028 17.1 0.0 0.0058 16.0 0.0 1.5 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 ELR17822.1 - 0.0032 17.5 1.1 0.008 16.2 0.1 2.2 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_14 PF13173.6 ELR17822.1 - 0.0052 16.8 0.0 0.012 15.6 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_7 PF12775.7 ELR17822.1 - 0.0088 15.6 0.0 0.051 13.1 0.0 2.0 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_32 PF13654.6 ELR17822.1 - 0.02 13.7 0.0 0.02 13.7 0.0 1.6 2 0 0 2 2 2 0 AAA domain ATPase_2 PF01637.18 ELR17822.1 - 0.023 14.6 0.0 0.14 12.0 0.0 2.1 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea MMR_HSR1 PF01926.23 ELR17822.1 - 0.024 14.7 0.0 0.062 13.4 0.0 1.7 1 0 0 1 1 1 0 50S ribosome-binding GTPase PhoH PF02562.16 ELR17822.1 - 0.044 13.2 0.0 0.076 12.5 0.0 1.4 1 0 0 1 1 1 0 PhoH-like protein TrwB_AAD_bind PF10412.9 ELR17822.1 - 0.063 12.2 0.0 0.27 10.1 0.0 1.9 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain DEAD PF00270.29 ELR17822.1 - 0.063 13.0 0.0 6 6.6 0.0 2.4 2 0 0 2 2 2 0 DEAD/DEAH box helicase NACHT PF05729.12 ELR17822.1 - 0.067 13.1 0.0 0.14 12.0 0.0 1.5 1 0 0 1 1 1 0 NACHT domain AAA_29 PF13555.6 ELR17822.1 - 0.092 12.5 0.0 0.2 11.4 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain IstB_IS21 PF01695.17 ELR17822.1 - 0.15 11.8 0.0 11 5.7 0.0 2.3 2 0 0 2 2 2 0 IstB-like ATP binding protein UvrD-helicase PF00580.21 ELR17822.1 - 0.19 11.2 0.0 0.19 11.2 0.0 2.1 2 0 0 2 2 2 0 UvrD/REP helicase N-terminal domain Viral_helicase1 PF01443.18 ELR17822.1 - 0.59 9.8 6.7 0.5 10.1 0.1 3.4 3 1 0 3 3 3 0 Viral (Superfamily 1) RNA helicase MCPVI PF02993.14 ELR17822.1 - 1.7 8.4 9.7 0.066 13.0 3.4 1.9 2 1 0 2 2 2 0 Minor capsid protein VI Glyco_hydro_3_C PF01915.22 ELR17824.1 - 7e-41 140.4 0.0 1e-40 139.9 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Fn3-like PF14310.6 ELR17824.1 - 2.1e-16 59.8 1.4 7e-16 58.1 0.4 2.1 2 0 0 2 2 2 1 Fibronectin type III-like domain CARDB PF07705.11 ELR17824.1 - 0.0075 16.5 0.0 0.017 15.4 0.0 1.5 1 0 0 1 1 1 1 CARDB ASH PF15780.5 ELR17824.1 - 0.11 12.7 0.0 0.31 11.3 0.0 1.7 1 0 0 1 1 1 0 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin Beach PF02138.18 ELR17825.1 - 8.5e-123 409.1 0.0 1.6e-122 408.2 0.0 1.5 1 0 0 1 1 1 1 Beige/BEACH domain DUF4704 PF15787.5 ELR17825.1 - 9e-20 71.1 1.6 2.4e-17 63.1 0.2 2.9 2 1 1 3 3 3 2 Domain of unknown function (DUF4704) PH_BEACH PF14844.6 ELR17825.1 - 3.1e-18 65.7 0.0 3.1e-17 62.5 0.0 2.7 1 1 0 1 1 1 1 PH domain associated with Beige/BEACH WD40 PF00400.32 ELR17825.1 - 3.3e-08 34.0 0.6 0.0039 18.0 0.1 4.0 3 0 0 3 3 3 2 WD domain, G-beta repeat Laminin_G_3 PF13385.6 ELR17825.1 - 1.8e-06 28.2 0.0 3.9e-06 27.1 0.0 1.6 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily APH PF01636.23 ELR17826.1 - 2.2e-25 90.0 0.7 2.2e-25 90.0 0.7 2.0 2 0 0 2 2 2 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 ELR17826.1 - 5.7e-05 22.8 0.1 8.8e-05 22.2 0.1 1.2 1 0 0 1 1 1 1 Choline/ethanolamine kinase EcKinase PF02958.20 ELR17826.1 - 0.0011 18.4 0.0 0.0018 17.6 0.0 1.3 1 0 0 1 1 1 1 Ecdysteroid kinase Kdo PF06293.14 ELR17826.1 - 0.0063 15.9 0.2 0.021 14.2 0.2 1.8 1 1 1 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family DUF349 PF03993.12 ELR17826.1 - 0.023 15.0 0.1 13 6.2 0.0 2.8 3 0 0 3 3 3 0 Domain of Unknown Function (DUF349) Glyco_hydro_3 PF00933.21 ELR17827.1 - 3.4e-49 167.9 0.0 5.4e-49 167.3 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Glyco_hydro_3_C PF01915.22 ELR17827.1 - 7.1e-42 143.7 0.0 1.1e-41 143.0 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Fn3-like PF14310.6 ELR17827.1 - 4.6e-16 58.7 1.1 1.4e-15 57.1 0.4 2.1 2 0 0 2 2 2 1 Fibronectin type III-like domain CARDB PF07705.11 ELR17827.1 - 0.0092 16.2 0.1 0.028 14.7 0.1 1.8 1 0 0 1 1 1 1 CARDB PHP PF02811.19 ELR17827.1 - 0.0098 16.2 0.0 0.028 14.7 0.0 1.7 2 0 0 2 2 2 1 PHP domain Glyco_hydro_3 PF00933.21 ELR17828.1 - 4e-44 151.3 0.0 7.4e-44 150.4 0.0 1.5 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Glyco_hydro_3_C PF01915.22 ELR17828.1 - 1.1e-40 139.8 0.0 2e-40 139.0 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Fn3-like PF14310.6 ELR17828.1 - 4.3e-16 58.8 1.1 1.5e-15 57.1 0.4 2.2 2 0 0 2 2 2 1 Fibronectin type III-like domain CARDB PF07705.11 ELR17828.1 - 0.0088 16.3 0.1 0.028 14.7 0.1 1.9 1 0 0 1 1 1 1 CARDB RNase_P_p30 PF01876.16 ELR17829.1 - 2.2e-26 92.6 0.0 2e-15 56.9 0.0 2.1 1 1 1 2 2 2 2 RNase P subunit p30 NADH-u_ox-rdase PF10785.9 ELR17831.1 - 3.9e-11 43.5 0.0 4.3e-11 43.3 0.0 1.0 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase complex I, 21 kDa subunit A_deaminase PF00962.22 ELR17832.1 - 4.6e-168 558.6 0.0 1.4e-89 300.7 0.0 3.2 2 1 0 2 2 2 2 Adenosine/AMP deaminase Vault PF01505.18 ELR17832.1 - 0.089 13.0 0.1 71 3.7 0.0 3.7 3 0 0 3 3 3 0 Major Vault Protein repeat domain C1_4 PF07975.12 ELR17832.1 - 0.14 12.4 2.2 0.34 11.2 2.2 1.5 1 0 0 1 1 1 0 TFIIH C1-like domain zf-B_box PF00643.24 ELR17832.1 - 0.36 11.0 3.5 0.86 9.8 3.5 1.7 1 0 0 1 1 1 0 B-box zinc finger CTNNBL PF08216.11 ELR17833.1 - 5.5e-23 81.1 6.2 1.2e-11 44.7 1.5 4.2 3 1 0 3 3 3 2 Catenin-beta-like, Arm-motif containing nuclear E3_UbLigase_R4 PF13764.6 ELR17833.1 - 0.0021 16.3 0.5 0.55 8.3 0.0 2.3 2 0 0 2 2 2 2 E3 ubiquitin-protein ligase UBR4 MAD PF05557.13 ELR17834.1 - 4.2e-46 157.6 87.3 2e-45 155.4 87.3 1.8 1 1 0 1 1 1 1 Mitotic checkpoint protein adh_short PF00106.25 ELR17834.1 - 1.1e-29 103.3 1.2 6.5e-29 100.8 0.0 2.9 3 1 0 3 3 3 1 short chain dehydrogenase adh_short_C2 PF13561.6 ELR17834.1 - 1.2e-16 60.9 0.0 6.2e-16 58.7 0.0 2.2 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ELR17834.1 - 0.00013 21.9 0.7 0.0056 16.6 0.0 2.9 2 0 0 2 2 2 1 KR domain PKcGMP_CC PF16808.5 ELR17834.1 - 0.0006 19.6 1.9 0.0006 19.6 1.9 4.9 5 0 0 5 5 5 1 Coiled-coil N-terminus of cGMP-dependent protein kinase HALZ PF02183.18 ELR17834.1 - 0.0043 17.2 0.4 0.0043 17.2 0.4 8.7 8 1 0 8 8 8 2 Homeobox associated leucine zipper ZapB PF06005.12 ELR17834.1 - 0.0057 17.1 12.0 0.0057 17.1 12.0 10.2 7 2 0 7 7 5 1 Cell division protein ZapB NAD_binding_10 PF13460.6 ELR17834.1 - 0.015 15.2 0.1 0.015 15.2 0.1 3.8 4 0 0 4 4 4 0 NAD(P)H-binding bZIP_1 PF00170.21 ELR17834.1 - 0.017 15.2 1.1 0.017 15.2 1.1 9.6 9 1 1 10 10 9 0 bZIP transcription factor Transglut_prok PF09017.10 ELR17834.1 - 0.087 12.2 6.0 0.27 10.5 1.4 2.6 3 0 0 3 3 3 0 Microbial transglutaminase NAD_binding_2 PF03446.15 ELR17834.1 - 0.23 11.6 0.7 0.88 9.7 0.0 2.3 2 0 0 2 2 2 0 NAD binding domain of 6-phosphogluconate dehydrogenase DUF4435 PF14491.6 ELR17834.1 - 1.8 8.4 12.1 0.25 11.2 0.1 3.0 3 1 1 4 4 4 0 Protein of unknown function (DUF4435) PhaC_N PF07167.13 ELR17834.1 - 5.3 6.6 8.7 1.2 8.7 0.2 3.8 3 1 0 4 4 4 0 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus ubiquitin PF00240.23 ELR17837.1 - 1.4e-40 136.8 0.0 3.7e-24 84.3 0.0 2.8 2 0 0 2 2 2 2 Ubiquitin family bMG10 PF17973.1 ELR17837.1 - 2.2e-23 82.9 0.0 7.4e-23 81.2 0.0 2.0 1 0 0 1 1 1 1 Bacterial Alpha-2-macroglobulin MG10 domain Rad60-SLD PF11976.8 ELR17837.1 - 1.2e-20 73.1 0.9 1.1e-11 44.4 0.0 4.4 5 0 0 5 5 5 2 Ubiquitin-2 like Rad60 SUMO-like A2M PF00207.22 ELR17837.1 - 5e-17 61.6 0.0 1.5e-16 60.0 0.0 1.9 1 0 0 1 1 1 1 Alpha-2-macroglobulin family MG2 PF01835.19 ELR17837.1 - 1.6e-09 38.1 0.0 5.4e-08 33.2 0.0 3.0 2 0 0 2 2 2 1 MG2 domain A2M_BRD PF07703.14 ELR17837.1 - 5.3e-06 26.8 0.1 1.6e-05 25.3 0.1 1.9 1 0 0 1 1 1 1 Alpha-2-macroglobulin bait region domain bMG3 PF11974.8 ELR17837.1 - 3.5e-05 23.8 0.0 0.00014 21.8 0.0 2.1 1 0 0 1 1 1 1 Bacterial alpha-2-macroglobulin MG3 domain bMG5 PF17972.1 ELR17837.1 - 0.00043 20.6 0.0 0.0014 19.0 0.0 1.9 2 0 0 2 2 1 1 Bacterial Alpha-2-macroglobulin MG5 domain Big_5 PF13205.6 ELR17837.1 - 0.0021 18.7 0.2 0.26 12.0 0.0 3.6 3 0 0 3 3 2 1 Bacterial Ig-like domain Ubiquitin_5 PF18037.1 ELR17837.1 - 0.016 15.5 0.0 2.8 8.3 0.0 3.2 3 0 0 3 3 3 0 Ubiquitin-like domain Big_10 PF17964.1 ELR17837.1 - 0.029 14.4 0.0 0.47 10.4 0.0 2.7 2 0 0 2 2 2 0 Bacterial Ig domain TBK1_ULD PF18396.1 ELR17837.1 - 0.12 12.3 0.0 10 6.1 0.0 2.6 2 0 0 2 2 2 0 TANK binding kinase 1 ubiquitin-like domain Ubiquitin_2 PF14560.6 ELR17837.1 - 0.13 12.7 0.2 1.9 9.0 0.0 3.2 4 0 0 4 4 4 0 Ubiquitin-like domain AMP-binding PF00501.28 ELR17839.1 - 8.2e-105 350.8 0.2 1e-104 350.5 0.2 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 ELR17839.1 - 1.5e-21 77.2 0.9 3.7e-21 75.9 0.9 1.8 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Tctex-1 PF03645.13 ELR17840.1 - 9.1e-27 93.3 1.8 1e-26 93.2 1.8 1.0 1 0 0 1 1 1 1 Tctex-1 family HATPase_c PF02518.26 ELR17841.1 - 2.1e-28 99.0 0.0 1.8e-27 96.1 0.0 2.5 2 1 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 ELR17841.1 - 2.3e-26 91.6 2.7 9e-19 67.3 0.1 3.0 2 0 0 2 2 2 2 His Kinase A (phospho-acceptor) domain Response_reg PF00072.24 ELR17841.1 - 3.1e-21 75.6 2.0 7.2e-21 74.5 2.0 1.7 1 0 0 1 1 1 1 Response regulator receiver domain PAS_3 PF08447.12 ELR17841.1 - 1.4e-07 31.6 0.7 4.9e-07 30.0 0.1 2.2 2 0 0 2 2 2 1 PAS fold PAS PF00989.25 ELR17841.1 - 2.3e-05 24.4 0.0 6.8e-05 22.8 0.0 1.8 1 0 0 1 1 1 1 PAS fold PAS_8 PF13188.7 ELR17841.1 - 0.00022 21.2 0.0 0.0034 17.4 0.0 2.8 3 0 0 3 3 3 1 PAS domain PAS_9 PF13426.7 ELR17841.1 - 0.00037 20.7 0.0 0.0026 18.0 0.0 2.5 2 0 0 2 2 2 1 PAS domain PAS_4 PF08448.10 ELR17841.1 - 0.0036 17.5 0.0 0.014 15.7 0.0 2.1 1 0 0 1 1 1 1 PAS fold OPA3 PF07047.12 ELR17841.1 - 7.1 6.4 8.4 21 4.9 0.0 3.6 3 0 0 3 3 3 0 Optic atrophy 3 protein (OPA3) tRNA-synt_2d PF01409.20 ELR17842.1 - 6.6e-51 173.2 0.8 2.2e-50 171.4 0.8 1.8 1 1 0 1 1 1 1 tRNA synthetases class II core domain (F) FDX-ACB PF03147.14 ELR17842.1 - 1.3e-26 92.8 0.0 6.4e-26 90.6 0.0 2.2 3 0 0 3 3 3 1 Ferredoxin-fold anticodon binding domain Abhydrolase_3 PF07859.13 ELR17843.1 - 2.8e-33 115.6 0.0 5.6e-24 85.2 0.0 2.5 2 0 0 2 2 2 2 alpha/beta hydrolase fold Say1_Mug180 PF10340.9 ELR17843.1 - 2.3e-12 46.5 0.0 3.5e-11 42.6 0.0 2.1 2 0 0 2 2 2 1 Steryl acetyl hydrolase Frag1 PF10277.9 ELR17844.1 - 2.7e-14 53.2 6.0 4.2e-14 52.6 6.0 1.2 1 0 0 1 1 1 1 Frag1/DRAM/Sfk1 family DUF872 PF05915.12 ELR17844.1 - 0.16 12.2 0.7 0.49 10.6 0.9 1.8 2 0 0 2 2 2 0 Eukaryotic protein of unknown function (DUF872) Pox_A14 PF05767.12 ELR17844.1 - 0.52 10.5 2.6 0.31 11.2 0.4 1.8 2 0 0 2 2 2 0 Poxvirus virion envelope protein A14 Phage_holin_3_6 PF07332.11 ELR17844.1 - 5.4 7.1 9.6 2.4 8.2 3.8 2.7 2 1 0 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III DUF4114 PF13448.6 ELR17845.1 - 1.3e-10 41.9 0.0 2.3e-10 41.1 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4114) DUF5593 PF18007.1 ELR17846.1 - 0.08 13.6 0.2 0.17 12.6 0.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF5593) DEAD PF00270.29 ELR17847.1 - 4.4e-27 95.0 0.0 1.6e-26 93.2 0.0 1.9 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ELR17847.1 - 4.8e-22 78.4 0.0 2e-21 76.4 0.0 2.1 2 1 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 ELR17847.1 - 2.1e-06 27.8 0.0 0.00014 21.9 0.0 2.4 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Thioredoxin PF00085.20 ELR17848.1 - 3.6e-37 126.5 0.0 2.3e-28 98.2 0.0 2.5 2 0 0 2 2 2 2 Thioredoxin Thioredoxin_6 PF13848.6 ELR17848.1 - 2.3e-12 47.2 0.0 1.2e-05 25.3 0.0 2.8 2 1 0 2 2 2 2 Thioredoxin-like domain Thioredoxin_2 PF13098.6 ELR17848.1 - 2.5e-09 37.6 0.4 0.0027 18.1 0.0 2.9 3 0 0 3 3 3 2 Thioredoxin-like domain Thioredoxin_8 PF13905.6 ELR17848.1 - 4.7e-07 30.1 0.0 0.011 16.1 0.0 3.2 2 1 1 3 3 3 2 Thioredoxin-like TraF PF13728.6 ELR17848.1 - 0.00017 21.5 1.0 0.83 9.4 0.0 3.1 3 0 0 3 3 3 2 F plasmid transfer operon protein AhpC-TSA PF00578.21 ELR17848.1 - 0.00017 21.5 0.0 0.019 14.8 0.0 2.4 2 0 0 2 2 2 1 AhpC/TSA family HyaE PF07449.11 ELR17848.1 - 0.0019 18.1 0.0 0.13 12.2 0.0 2.6 2 1 0 2 2 2 1 Hydrogenase-1 expression protein HyaE OST3_OST6 PF04756.13 ELR17848.1 - 0.02 14.2 0.0 0.39 10.0 0.0 2.4 1 1 2 3 3 3 0 OST3 / OST6 family, transporter family Thioredoxin_5 PF13743.6 ELR17848.1 - 0.031 14.0 0.0 2.1 8.0 0.0 2.5 2 0 0 2 2 2 0 Thioredoxin Thioredoxin_4 PF13462.6 ELR17848.1 - 0.044 13.9 0.1 2.3 8.4 0.1 2.4 2 0 0 2 2 2 0 Thioredoxin Thioredoxin_7 PF13899.6 ELR17848.1 - 0.11 12.7 0.0 0.33 11.2 0.0 1.9 1 0 0 1 1 1 0 Thioredoxin-like GrpB PF04229.14 ELR17848.1 - 0.15 12.2 0.0 0.34 11.1 0.0 1.5 1 0 0 1 1 1 0 GrpB protein Pkinase_Tyr PF07714.17 ELR17849.1 - 2.1e-61 207.5 0.0 2.5e-61 207.2 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ELR17849.1 - 2.1e-58 197.8 0.0 2.6e-58 197.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.23 ELR17849.1 - 4.3e-06 26.8 0.0 0.00029 20.8 0.0 2.5 2 1 0 3 3 3 1 Phosphotransferase enzyme family CobT PF06213.12 ELR17849.1 - 0.0084 15.5 0.6 0.011 15.1 0.6 1.2 1 0 0 1 1 1 1 Cobalamin biosynthesis protein CobT Utp14 PF04615.13 ELR17849.1 - 0.027 13.1 0.8 0.036 12.7 0.8 1.1 1 0 0 1 1 1 0 Utp14 protein Pkinase_fungal PF17667.1 ELR17849.1 - 0.03 13.1 0.0 0.048 12.4 0.0 1.3 1 0 0 1 1 1 0 Fungal protein kinase Haspin_kinase PF12330.8 ELR17849.1 - 0.06 12.3 0.0 0.089 11.7 0.0 1.4 1 1 0 1 1 1 0 Haspin like kinase domain RIO1 PF01163.22 ELR17849.1 - 0.072 12.7 0.0 0.12 11.9 0.0 1.4 1 1 0 1 1 1 0 RIO1 family Kdo PF06293.14 ELR17849.1 - 0.14 11.5 0.0 0.21 10.9 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Hep_59 PF07052.11 ELR17849.1 - 0.22 12.3 2.9 2.6 8.9 0.0 2.4 2 0 0 2 2 2 0 Hepatocellular carcinoma-associated antigen 59 Cwf_Cwc_15 PF04889.12 ELR17849.1 - 1.6 8.4 9.9 2.8 7.6 9.9 1.4 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein CDC45 PF02724.14 ELR17849.1 - 4.1 5.6 5.7 5.8 5.1 5.7 1.1 1 0 0 1 1 1 0 CDC45-like protein adh_short PF00106.25 ELR17850.1 - 1e-29 103.4 0.0 8.9e-29 100.3 0.0 2.0 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ELR17850.1 - 3.3e-21 75.9 0.0 2.3e-20 73.2 0.0 2.0 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ELR17850.1 - 3.8e-08 33.4 0.0 6.1e-08 32.8 0.0 1.3 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 ELR17850.1 - 3.2e-06 26.8 0.0 4e-06 26.5 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 ELR17850.1 - 0.00037 20.4 0.0 0.0015 18.4 0.0 1.9 2 0 0 2 2 2 1 NAD(P)H-binding DUF1776 PF08643.10 ELR17850.1 - 0.008 15.6 0.1 0.048 13.0 0.1 1.9 1 1 0 1 1 1 1 Fungal family of unknown function (DUF1776) GDP_Man_Dehyd PF16363.5 ELR17850.1 - 0.064 12.7 0.0 0.072 12.5 0.0 1.2 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase LRR_6 PF13516.6 ELR17851.1 - 5.6e-19 66.5 9.5 0.055 13.6 0.1 10.7 11 0 0 11 11 11 6 Leucine Rich repeat LRR_4 PF12799.7 ELR17851.1 - 2.1e-15 56.6 5.8 0.0022 18.4 0.0 6.3 5 3 2 7 7 7 4 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 ELR17851.1 - 3.2e-11 42.2 24.7 2.2 9.2 0.2 10.4 8 2 1 9 9 9 3 Leucine Rich Repeat LRR_8 PF13855.6 ELR17851.1 - 1.1e-09 37.9 9.5 0.077 12.8 1.2 5.4 3 2 3 6 6 6 3 Leucine rich repeat F-box PF00646.33 ELR17851.1 - 4.7e-08 32.7 0.6 4.7e-08 32.7 0.6 3.5 4 0 0 4 4 4 1 F-box domain F-box-like PF12937.7 ELR17851.1 - 7.7e-07 28.9 0.6 7.7e-07 28.9 0.6 3.3 3 0 0 3 3 3 1 F-box-like F-box_5 PF18511.1 ELR17851.1 - 0.18 11.4 0.4 2.3 7.9 0.6 2.3 2 0 0 2 2 2 0 F-box SAM_Ste50p PF09235.10 ELR17851.1 - 0.67 10.2 2.6 50 4.2 0.0 4.0 5 0 0 5 5 5 0 Ste50p, sterile alpha motif CBS PF00571.28 ELR17852.1 - 4e-33 113.7 1.2 2.9e-09 37.2 0.1 4.2 4 0 0 4 4 4 4 CBS domain PRC PF05239.16 ELR17852.1 - 0.042 13.9 0.1 2 8.6 0.0 2.6 2 0 0 2 2 2 0 PRC-barrel domain SAC3_GANP PF03399.16 ELR17853.1 - 3.7e-86 289.1 0.1 8.2e-86 288.0 0.1 1.6 1 0 0 1 1 1 1 SAC3/GANP family MCM3AP_GANP PF16769.5 ELR17853.1 - 3.9e-18 65.1 0.0 3.9e-18 65.1 0.0 2.8 2 1 0 2 2 2 1 MCM3AP domain of GANP CSN8_PSD8_EIF3K PF10075.9 ELR17853.1 - 0.018 15.0 0.0 0.04 13.9 0.0 1.5 1 0 0 1 1 1 0 CSN8/PSMD8/EIF3K family F-box-like PF12937.7 ELR17854.1 - 3.3e-13 49.3 1.1 8.5e-13 48.0 1.1 1.8 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ELR17854.1 - 8.3e-07 28.7 0.4 1.9e-06 27.6 0.4 1.7 1 0 0 1 1 1 1 F-box domain Arrestin_N PF00339.29 ELR17854.1 - 1.9e-06 28.0 0.0 5.2e-06 26.6 0.0 1.7 1 0 0 1 1 1 1 Arrestin (or S-antigen), N-terminal domain Ephrin_rec_like PF07699.13 ELR17854.1 - 2.6e-06 27.1 9.9 0.00011 21.9 0.4 2.9 2 0 0 2 2 2 2 Putative ephrin-receptor like DUF4972 PF16342.5 ELR17854.1 - 0.11 12.2 0.1 21 4.8 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4972) CDC27 PF09507.10 ELR17854.1 - 0.12 11.8 4.2 0.22 10.9 4.2 1.3 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 NCD3G PF07562.14 ELR17854.1 - 1.7 8.6 9.4 3.2 7.8 3.0 2.9 2 0 0 2 2 2 0 Nine Cysteines Domain of family 3 GPCR Stc1 PF12898.7 ELR17855.1 - 0.012 16.2 3.2 0.022 15.3 3.2 1.5 1 0 0 1 1 1 0 Stc1 domain SDA1 PF05285.12 ELR17855.1 - 0.16 11.4 16.6 0.18 11.2 16.6 1.1 1 0 0 1 1 1 0 SDA1 CDC45 PF02724.14 ELR17855.1 - 0.29 9.4 11.1 0.39 9.0 11.1 1.2 1 0 0 1 1 1 0 CDC45-like protein GFA PF04828.14 ELR17855.1 - 0.51 10.7 4.0 8.8 6.7 0.3 2.3 1 1 1 2 2 2 0 Glutathione-dependent formaldehyde-activating enzyme Nop14 PF04147.12 ELR17855.1 - 2.3 6.3 16.6 2.7 6.1 16.6 1.1 1 0 0 1 1 1 0 Nop14-like family Scramblase PF03803.15 ELR17856.1 - 6.8e-13 48.4 0.0 7.9e-13 48.2 0.0 1.1 1 0 0 1 1 1 1 Scramblase Pkinase_Tyr PF07714.17 ELR17857.1 - 4.4e-127 422.7 0.0 4.3e-63 213.0 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 ELR17857.1 - 2.7e-110 367.9 0.0 1.9e-56 191.3 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Guanylate_cyc PF00211.20 ELR17857.1 - 1.4e-12 47.6 0.0 2.4e-12 46.9 0.0 1.3 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain APH PF01636.23 ELR17857.1 - 3e-07 30.6 0.1 0.00024 21.1 0.0 2.7 2 0 0 2 2 2 2 Phosphotransferase enzyme family Haspin_kinase PF12330.8 ELR17857.1 - 6.9e-05 21.9 0.1 0.0055 15.7 0.0 2.2 2 0 0 2 2 2 1 Haspin like kinase domain Kdo PF06293.14 ELR17857.1 - 0.00011 21.7 0.4 0.21 10.9 0.1 2.3 2 0 0 2 2 2 2 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 ELR17857.1 - 0.00036 19.9 0.0 0.15 11.4 0.0 2.3 2 0 0 2 2 2 2 Kinase-like RIO1 PF01163.22 ELR17857.1 - 0.0034 17.0 1.0 1.9 8.1 0.1 2.4 2 0 0 2 2 2 2 RIO1 family FTA2 PF13095.6 ELR17857.1 - 0.0079 15.8 0.0 0.39 10.3 0.0 2.8 2 1 1 3 3 3 1 Kinetochore Sim4 complex subunit FTA2 EGF_2 PF07974.13 ELR17857.1 - 0.015 15.7 13.9 0.027 14.8 13.9 1.5 1 0 0 1 1 1 0 EGF-like domain EGF PF00008.27 ELR17857.1 - 0.017 15.4 5.4 0.033 14.5 5.4 1.4 1 0 0 1 1 1 0 EGF-like domain hEGF PF12661.7 ELR17857.1 - 0.075 13.7 4.9 0.18 12.5 4.9 1.7 1 0 0 1 1 1 0 Human growth factor-like EGF EGF_CA PF07645.15 ELR17857.1 - 1.4 9.2 9.1 3.4 8.0 9.1 1.5 1 0 0 1 1 1 0 Calcium-binding EGF domain Peptidase_C78 PF07910.13 ELR17858.1 - 3.9e-10 39.6 0.1 1.2e-09 37.9 0.1 1.7 1 1 0 1 1 1 1 Peptidase family C78 LIM PF00412.22 ELR17858.1 - 7.7e-09 35.6 0.8 1.5e-08 34.7 0.8 1.5 1 0 0 1 1 1 1 LIM domain Peptidase_C54 PF03416.19 ELR17858.1 - 0.0053 16.2 0.1 0.012 15.0 0.1 1.6 2 0 0 2 2 2 1 Peptidase family C54 DUF1495 PF07381.11 ELR17858.1 - 0.38 10.6 5.1 8.5 6.3 0.1 3.7 3 1 1 4 4 4 0 Winged helix DNA-binding domain (DUF1495) DMAP1 PF05499.12 ELR17859.1 - 4.3e-06 26.7 0.4 4.3e-06 26.7 0.4 2.3 2 1 0 2 2 2 1 DNA methyltransferase 1-associated protein 1 (DMAP1) LAGLIDADG_3 PF14528.6 ELR17859.1 - 0.15 12.4 0.0 0.31 11.4 0.0 1.5 1 0 0 1 1 1 0 LAGLIDADG-like domain DUF1639 PF07797.14 ELR17859.1 - 0.41 10.7 0.2 0.41 10.7 0.2 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF1639) SANT_DAMP1_like PF16282.5 ELR17860.1 - 2.4e-32 111.0 3.6 3.7e-32 110.4 3.6 1.3 1 0 0 1 1 1 1 SANT/Myb-like domain of DAMP1 Myb_DNA-bind_7 PF15963.5 ELR17860.1 - 0.00015 21.6 0.8 0.00026 20.8 0.8 1.5 1 0 0 1 1 1 1 Myb DNA-binding like Myb_DNA-bind_6 PF13921.6 ELR17860.1 - 0.00058 20.1 0.7 0.0012 19.0 0.1 1.9 2 0 0 2 2 2 1 Myb-like DNA-binding domain Myb_DNA-binding PF00249.31 ELR17860.1 - 0.00058 20.0 0.0 0.001 19.2 0.0 1.5 1 0 0 1 1 1 1 Myb-like DNA-binding domain TRAP-gamma PF07074.12 ELR17861.1 - 8.9e-31 106.7 1.0 1.3e-30 106.2 1.0 1.2 1 0 0 1 1 1 1 Translocon-associated protein, gamma subunit (TRAP-gamma) Tom6 PF17112.5 ELR17861.1 - 0.071 12.6 0.4 0.19 11.3 0.0 1.9 2 0 0 2 2 2 0 Mitochondrial import receptor subunit Tom6, fungal EMP24_GP25L PF01105.24 ELR17862.1 - 9.6e-40 136.5 0.7 1.2e-39 136.1 0.7 1.1 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD DUF4271 PF14093.6 ELR17862.1 - 0.11 12.3 0.2 0.11 12.3 0.2 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4271) EMP24_GP25L PF01105.24 ELR17864.1 - 0.00032 20.7 0.0 0.00032 20.7 0.0 1.3 2 0 0 2 2 2 1 emp24/gp25L/p24 family/GOLD BACK PF07707.15 ELR17865.1 - 0.11 12.6 2.0 7.9 6.6 0.1 2.5 2 0 0 2 2 2 0 BTB And C-terminal Kelch GTP_EFTU_D3 PF03143.17 ELR17867.1 - 0.013 15.8 0.1 0.021 15.1 0.1 1.3 1 0 0 1 1 1 0 Elongation factor Tu C-terminal domain Ank_3 PF13606.6 ELR17867.1 - 0.029 14.9 2.6 0.14 12.8 0.1 2.9 3 0 0 3 3 3 0 Ankyrin repeat zf-ZPR1 PF03367.13 ELR17869.1 - 6.9e-113 373.7 0.0 9.4e-59 197.8 0.0 2.2 2 0 0 2 2 2 2 ZPR1 zinc-finger domain zf-RRPl_C4 PF17026.5 ELR17869.1 - 0.3 11.2 1.4 2.1 8.5 0.1 2.2 2 0 0 2 2 2 0 Putative ribonucleoprotein zinc-finger pf C4 type PP2C PF00481.21 ELR17870.1 - 2e-11 44.0 3.0 2.4e-09 37.2 0.1 2.7 2 1 1 3 3 3 2 Protein phosphatase 2C CFIA_Pcf11 PF11526.8 ELR17870.1 - 0.15 12.6 5.2 5.7 7.5 0.8 2.3 2 0 0 2 2 2 0 Subunit of cleavage factor IA Pcf11 Nop14 PF04147.12 ELR17870.1 - 3.9 5.6 11.2 5.6 5.0 11.2 1.3 1 0 0 1 1 1 0 Nop14-like family P120R PF08062.11 ELR17871.1 - 0.25 11.8 1.2 0.6 10.5 1.2 1.7 1 0 0 1 1 1 0 P120R (NUC006) repeat MyTH4 PF00784.17 ELR17871.1 - 1.4 9.4 5.3 0.38 11.3 1.0 2.1 2 0 0 2 2 2 0 MyTH4 domain ANF_receptor PF01094.28 ELR17872.1 - 0.057 12.5 0.0 0.27 10.3 0.0 1.9 2 0 0 2 2 2 0 Receptor family ligand binding region PP2C PF00481.21 ELR17873.1 - 1.1e-31 110.4 0.0 1.3e-31 110.1 0.0 1.1 1 0 0 1 1 1 1 Protein phosphatase 2C Glyco_tranf_2_4 PF13704.6 ELR17874.1 - 4.1e-08 33.6 1.4 1.7e-07 31.7 0.1 2.1 2 0 0 2 2 2 1 Glycosyl transferase family 2 Glyco_transf_92 PF01697.27 ELR17874.1 - 6.6e-07 29.2 1.2 8.7e-07 28.8 0.1 1.6 2 0 0 2 2 2 1 Glycosyltransferase family 92 Glyco_transf_92 PF01697.27 ELR17875.1 - 3.5e-16 59.7 0.8 5.2e-16 59.1 0.8 1.4 1 1 0 1 1 1 1 Glycosyltransferase family 92 Glyco_tranf_2_4 PF13704.6 ELR17875.1 - 9.8e-13 48.5 2.0 2.3e-12 47.3 0.2 2.2 2 0 0 2 2 2 1 Glycosyl transferase family 2 Glycos_transf_2 PF00535.26 ELR17875.1 - 2.5e-05 24.1 0.0 4.8e-05 23.2 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 2 CutC PF03932.14 ELR17876.1 - 9.9e-74 247.2 0.5 1.2e-73 247.0 0.5 1.0 1 0 0 1 1 1 1 CutC family NAPRTase PF04095.16 ELR17876.1 - 0.078 12.6 0.0 4.1 6.9 0.0 2.0 2 0 0 2 2 2 0 Nicotinate phosphoribosyltransferase (NAPRTase) family DOPA_dioxygen PF08883.11 ELR17877.1 - 2.3e-13 50.2 0.8 2.5e-09 37.2 0.2 2.2 1 1 1 2 2 2 2 Dopa 4,5-dioxygenase family TFIID_NTD2 PF04494.15 ELR17877.1 - 0.018 15.2 0.2 0.028 14.6 0.2 1.2 1 0 0 1 1 1 0 WD40 associated region in TFIID subunit, NTD2 domain ACT_7 PF13840.6 ELR17878.1 - 7.2e-21 73.7 0.8 6.7e-12 45.0 0.4 2.4 2 0 0 2 2 2 2 ACT domain Castor1_N PF18700.1 ELR17878.1 - 8.6e-09 35.1 0.1 5.8e-06 26.0 0.1 2.6 2 0 0 2 2 2 2 Cytosolic arginine sensor for mTORC1 subunit 1 N-terminal domain uDENN PF03456.18 ELR17879.1 - 3.2e-13 50.2 2.3 1.3e-12 48.3 0.2 3.1 3 1 0 3 3 3 1 uDENN domain DENN PF02141.21 ELR17879.1 - 4e-07 30.2 0.1 9e-07 29.0 0.1 1.6 1 0 0 1 1 1 1 DENN (AEX-3) domain dDENN PF03455.19 ELR17879.1 - 7.1e-06 25.9 0.3 2.2e-05 24.3 0.3 1.8 1 0 0 1 1 1 1 dDENN domain Serine_rich PF08824.10 ELR17880.1 - 7.6e-05 22.8 0.4 0.00014 21.9 0.4 1.3 1 0 0 1 1 1 1 Serine rich protein interaction domain Vfa1 PF08432.10 ELR17880.1 - 0.0096 16.3 0.7 0.015 15.7 0.7 1.2 1 0 0 1 1 1 1 AAA-ATPase Vps4-associated protein 1 Sel1 PF08238.12 ELR17881.1 - 1.4e-19 70.1 10.4 1.9e-06 28.4 0.2 3.9 4 0 0 4 4 4 3 Sel1 repeat TPR_6 PF13174.6 ELR17881.1 - 0.0043 17.6 4.1 0.25 12.1 0.0 3.5 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_16 PF13432.6 ELR17881.1 - 0.035 14.7 2.9 1.8 9.3 0.2 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat NSF PF02071.20 ELR17881.1 - 9.2 7.5 8.7 73 4.9 0.3 3.7 3 0 0 3 3 3 0 Aromatic-di-Alanine (AdAR) repeat Sel1 PF08238.12 ELR17882.1 - 1.3e-16 60.6 6.3 3.7e-09 37.0 0.2 3.6 3 1 0 3 3 3 3 Sel1 repeat R2K_2 PF18299.1 ELR17882.1 - 0.0095 15.8 0.0 0.014 15.2 0.0 1.2 1 0 0 1 1 1 1 ATP-grasp domain, R2K clade family 2 TPR_7 PF13176.6 ELR17882.1 - 0.058 13.4 1.1 1.5 9.0 0.0 3.0 3 1 0 3 3 3 0 Tetratricopeptide repeat Flu_M1_C PF08289.11 ELR17882.1 - 0.07 13.4 0.4 2.7 8.2 0.0 2.6 1 1 1 2 2 2 0 Influenza Matrix protein (M1) C-terminal domain TPR_6 PF13174.6 ELR17882.1 - 0.12 13.0 8.4 0.82 10.4 0.1 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat PHP PF02811.19 ELR17882.1 - 0.17 12.2 0.6 5.6 7.2 0.1 2.1 2 0 0 2 2 2 0 PHP domain TPR_1 PF00515.28 ELR17882.1 - 1.7 8.6 4.2 2.9 7.8 0.4 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF1736 PF08409.11 ELR17883.1 - 4e-17 62.0 1.9 9.5e-17 60.8 1.9 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF1736) TPR_8 PF13181.6 ELR17883.1 - 2.1e-06 27.5 0.4 0.0057 16.8 0.0 2.8 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 ELR17883.1 - 1.4e-05 24.8 3.7 0.0016 18.4 0.2 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_6 PF13174.6 ELR17883.1 - 0.00014 22.2 1.8 4.4 8.2 0.0 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.6 ELR17883.1 - 0.00015 22.3 1.2 0.0054 17.4 0.3 3.4 2 1 2 4 4 4 1 Tetratricopeptide repeat TPR_19 PF14559.6 ELR17883.1 - 0.0003 21.2 0.1 0.2 12.2 0.0 2.3 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.28 ELR17883.1 - 0.0028 17.4 0.1 0.0028 17.4 0.1 2.8 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_16 PF13432.6 ELR17883.1 - 0.0051 17.4 3.3 0.061 14.0 2.1 2.7 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.6 ELR17883.1 - 0.013 15.8 1.9 0.17 12.2 0.2 2.8 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_17 PF13431.6 ELR17883.1 - 0.18 12.3 1.5 1.2 9.6 0.0 3.2 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_7 PF13176.6 ELR17883.1 - 0.23 11.6 0.6 1.1 9.4 0.1 2.3 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_11 PF13414.6 ELR17883.1 - 0.62 9.8 2.9 1.1 9.0 0.0 2.7 3 0 0 3 3 3 0 TPR repeat SH2 PF00017.24 ELR17884.1 - 7.3e-14 51.6 0.0 1.3e-13 50.9 0.0 1.4 1 0 0 1 1 1 1 SH2 domain Pkinase_Tyr PF07714.17 ELR17884.1 - 2.2e-11 43.5 0.0 3.5e-11 42.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ELR17884.1 - 2.8e-07 30.2 0.0 4.3e-07 29.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain ECR1_N PF14382.6 ELR17884.1 - 0.081 12.7 0.1 0.2 11.5 0.1 1.6 1 0 0 1 1 1 0 Exosome complex exonuclease RRP4 N-terminal region AAA_35 PF14516.6 ELR17885.1 - 1.2e-05 24.3 0.0 3.3e-05 22.9 0.0 1.6 1 1 0 1 1 1 1 AAA-like domain AAA_22 PF13401.6 ELR17885.1 - 3.7e-05 24.0 0.0 0.00014 22.2 0.0 1.9 2 0 0 2 2 2 1 AAA domain ATPase PF06745.13 ELR17885.1 - 0.002 17.5 0.1 0.0058 16.0 0.0 1.7 1 1 0 2 2 2 1 KaiC AAA_16 PF13191.6 ELR17885.1 - 0.0028 18.1 1.8 0.038 14.4 1.8 2.2 1 1 0 1 1 1 1 AAA ATPase domain AAA_18 PF13238.6 ELR17885.1 - 0.0049 17.4 0.0 0.0075 16.8 0.0 1.2 1 0 0 1 1 1 1 AAA domain NACHT PF05729.12 ELR17885.1 - 0.0067 16.4 0.0 0.032 14.2 0.0 2.1 2 1 0 2 2 2 1 NACHT domain AAA_30 PF13604.6 ELR17885.1 - 0.03 14.0 0.0 0.044 13.5 0.0 1.3 1 0 0 1 1 1 0 AAA domain KTI12 PF08433.10 ELR17885.1 - 0.037 13.5 0.0 0.052 13.0 0.0 1.2 1 0 0 1 1 1 0 Chromatin associated protein KTI12 MeaB PF03308.16 ELR17885.1 - 0.079 11.9 0.0 0.12 11.4 0.0 1.2 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Acetyltransf_1 PF00583.25 ELR17886.1 - 3.8e-09 36.8 0.0 4.7e-09 36.5 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 ELR17886.1 - 2.4e-05 24.3 0.0 3.2e-05 23.8 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 ELR17886.1 - 2.5e-05 24.6 0.0 3.5e-05 24.1 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 ELR17886.1 - 0.00015 21.8 0.0 0.00019 21.5 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Methyltrn_RNA_4 PF09936.9 ELR17886.1 - 0.07 13.0 0.1 10 5.9 0.0 2.3 2 0 0 2 2 2 0 SAM-dependent RNA methyltransferase Aminotran_1_2 PF00155.21 ELR17887.1 - 8e-90 301.6 0.0 9.3e-90 301.4 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II LRR_8 PF13855.6 ELR17888.1 - 1.6e-17 63.0 0.3 7.1e-09 35.3 0.1 2.2 2 0 0 2 2 2 2 Leucine rich repeat LRR_4 PF12799.7 ELR17888.1 - 2e-10 40.7 0.6 1.1e-05 25.7 0.1 2.9 2 1 0 3 3 3 2 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 ELR17888.1 - 8.3e-09 34.8 9.4 0.27 11.9 0.0 6.7 7 0 0 7 7 7 3 Leucine Rich Repeat LRR_6 PF13516.6 ELR17888.1 - 1e-05 25.2 3.4 0.21 11.7 0.0 4.8 5 0 0 5 5 5 3 Leucine Rich repeat Pkinase PF00069.25 ELR17890.1 - 4.6e-47 160.6 0.0 8e-47 159.8 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR17890.1 - 1.8e-36 125.7 0.0 2.5e-36 125.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase EDR1 PF14381.6 ELR17890.1 - 1.6e-21 77.0 0.1 2.5e-21 76.3 0.1 1.2 1 0 0 1 1 1 1 Ethylene-responsive protein kinase Le-CTR1 Pkinase_fungal PF17667.1 ELR17890.1 - 0.00013 20.9 0.0 0.00021 20.2 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 ELR17890.1 - 0.02 14.2 0.0 0.034 13.4 0.0 1.3 1 0 0 1 1 1 0 Kinase-like DUF1681 PF07933.14 ELR17890.1 - 0.027 14.2 0.0 0.06 13.1 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1681) Kdo PF06293.14 ELR17890.1 - 0.032 13.6 0.0 0.059 12.7 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DUF5122 PF17164.4 ELR17891.1 - 0.24 11.7 3.2 0.85 10.0 0.3 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF5122) beta-propeller TPR_1 PF00515.28 ELR17892.1 - 4.6e-28 95.9 37.5 1.2e-05 24.9 0.0 8.9 9 0 0 9 9 9 6 Tetratricopeptide repeat ANAPC8 PF04049.13 ELR17892.1 - 4.2e-24 85.2 0.4 4.2e-24 85.2 0.4 2.5 2 1 0 2 2 2 1 Anaphase promoting complex subunit 8 / Cdc23 TPR_2 PF07719.17 ELR17892.1 - 9.7e-23 78.4 45.7 0.0034 17.4 0.2 9.9 9 1 1 10 10 10 6 Tetratricopeptide repeat TPR_14 PF13428.6 ELR17892.1 - 2.5e-21 74.5 30.2 4.8e-06 27.0 0.7 9.4 7 3 2 9 9 9 5 Tetratricopeptide repeat TPR_8 PF13181.6 ELR17892.1 - 5.3e-18 63.7 33.7 0.00068 19.7 0.0 9.6 9 1 1 10 10 10 5 Tetratricopeptide repeat TPR_11 PF13414.6 ELR17892.1 - 5.1e-15 54.9 6.2 6e-07 29.0 0.2 5.9 3 2 3 6 6 6 3 TPR repeat TPR_19 PF14559.6 ELR17892.1 - 1.1e-13 51.5 25.6 0.11 13.0 0.1 8.3 5 2 3 8 8 8 6 Tetratricopeptide repeat TPR_7 PF13176.6 ELR17892.1 - 6.9e-13 47.6 23.0 0.00037 20.3 0.6 7.6 8 1 0 8 8 7 3 Tetratricopeptide repeat TPR_12 PF13424.6 ELR17892.1 - 1.1e-12 48.1 32.1 4.3e-07 30.1 1.6 7.8 7 2 0 7 7 7 3 Tetratricopeptide repeat TPR_16 PF13432.6 ELR17892.1 - 8.3e-12 45.6 28.2 0.00011 22.8 0.1 7.4 5 2 2 7 7 7 4 Tetratricopeptide repeat TPR_17 PF13431.6 ELR17892.1 - 4.1e-11 42.5 12.6 0.043 14.2 0.0 7.7 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_15 PF13429.6 ELR17892.1 - 0.00012 21.4 10.5 0.0031 16.8 0.6 4.7 3 1 2 5 5 5 2 Tetratricopeptide repeat TPR_MalT PF17874.1 ELR17892.1 - 0.0003 20.3 10.4 0.037 13.4 4.1 3.5 3 1 0 4 4 4 2 MalT-like TPR region ANAPC3 PF12895.7 ELR17892.1 - 0.00057 20.1 34.5 0.042 14.1 1.2 7.2 5 4 3 8 8 8 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_9 PF13371.6 ELR17892.1 - 0.0027 17.8 13.7 0.87 9.8 0.1 5.7 4 1 0 6 6 6 1 Tetratricopeptide repeat TPR_10 PF13374.6 ELR17892.1 - 0.0071 16.2 38.9 0.04 13.8 1.4 8.3 8 1 1 9 9 9 1 Tetratricopeptide repeat DUF4919 PF16266.5 ELR17892.1 - 0.012 15.6 1.3 1.3 8.9 0.0 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4919) TPR_4 PF07721.14 ELR17892.1 - 0.042 14.5 14.2 5.3 8.0 0.0 6.5 6 0 0 6 6 5 0 Tetratricopeptide repeat DDE_Tnp_IS1595 PF12762.7 ELR17892.1 - 0.046 13.7 0.2 2.8 7.9 0.0 2.4 1 1 1 2 2 2 0 ISXO2-like transposase domain BTAD PF03704.17 ELR17892.1 - 0.063 13.7 0.1 0.063 13.7 0.1 4.1 3 2 3 6 6 5 0 Bacterial transcriptional activator domain TPR_5 PF12688.7 ELR17892.1 - 0.065 13.5 1.0 0.32 11.2 0.1 2.6 2 1 0 2 2 2 0 Tetratrico peptide repeat TPR_6 PF13174.6 ELR17892.1 - 0.11 13.2 36.3 4.6 8.1 0.0 10.2 10 1 0 10 10 9 0 Tetratricopeptide repeat Nmad4 PF18756.1 ELR17892.1 - 0.35 11.2 2.6 3.4 8.1 0.1 2.8 3 0 0 3 3 2 0 Nucleotide modification associated domain 4 PPR PF01535.20 ELR17892.1 - 2.8 8.4 9.9 43 4.7 0.1 5.1 6 0 0 6 6 5 0 PPR repeat DUF5534 PF17686.1 ELR17893.1 - 0.12 12.6 0.6 0.27 11.5 0.6 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5534) Glyco_transf_17 PF04724.13 ELR17894.1 - 1.6e-25 89.9 0.2 7.1e-25 87.8 0.2 1.8 1 1 0 1 1 1 1 Glycosyltransferase family 17 RasGEF PF00617.19 ELR17895.1 - 1.8e-34 119.5 0.0 3.1e-34 118.7 0.0 1.4 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 ELR17895.1 - 6.7e-24 84.1 0.1 2.3e-23 82.4 0.0 2.0 2 0 0 2 2 2 1 RasGEF N-terminal motif DEP PF00610.21 ELR17895.1 - 2.2e-10 40.4 0.1 6.7e-10 38.9 0.1 1.8 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) IBR PF01485.21 ELR17896.1 - 1.4e-14 54.0 44.6 5.4e-09 36.2 10.8 4.3 3 1 1 4 4 4 2 IBR domain, a half RING-finger domain zf-C3HC4_2 PF13923.6 ELR17896.1 - 8.7e-05 22.3 3.0 8.7e-05 22.3 3.0 4.2 4 0 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 ELR17896.1 - 0.0009 19.2 1.7 0.0009 19.2 1.7 3.2 3 0 0 3 3 3 2 RING-type zinc-finger zf-RING_2 PF13639.6 ELR17896.1 - 0.0011 19.2 4.6 0.0011 19.2 4.6 3.7 3 0 0 3 3 3 1 Ring finger domain zf-C3HC4 PF00097.25 ELR17896.1 - 0.0023 17.8 6.9 0.0023 17.8 6.9 3.8 3 1 1 4 4 4 1 Zinc finger, C3HC4 type (RING finger) NHase_beta PF02211.15 ELR17896.1 - 0.15 12.1 6.9 0.075 13.0 3.6 2.1 1 1 1 2 2 2 0 Nitrile hydratase beta subunit zf-RING_5 PF14634.6 ELR17896.1 - 5.8 7.0 40.0 0.026 14.5 6.5 3.5 3 0 0 3 3 3 0 zinc-RING finger domain UIM PF02809.20 ELR17896.1 - 9.9 6.3 30.1 0.14 12.1 0.9 4.8 4 1 1 5 5 5 0 Ubiquitin interaction motif Cellulase PF00150.18 ELR17897.1 - 3.5e-25 89.0 0.0 3.8e-20 72.5 0.0 2.2 2 0 0 2 2 2 2 Cellulase (glycosyl hydrolase family 5) Glyco_hydro_35 PF01301.19 ELR17897.1 - 3.9e-06 26.7 0.0 6.4e-06 26.0 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 35 Glyco_hydro_42 PF02449.15 ELR17897.1 - 2e-05 24.1 0.0 0.00036 20.0 0.0 2.1 2 0 0 2 2 2 1 Beta-galactosidase Glyco_hydro_5_C PF18564.1 ELR17897.1 - 0.00012 22.5 0.0 0.00028 21.3 0.0 1.7 1 0 0 1 1 1 1 Glycoside hydrolase family 5 C-terminal domain MRPL52 PF18699.1 ELR17898.1 - 3.8e-12 46.2 0.5 4.4e-12 46.0 0.5 1.1 1 0 0 1 1 1 1 Mitoribosomal protein mL52 DnaJ PF00226.31 ELR17899.1 - 2.7e-19 69.1 0.3 1e-18 67.2 0.3 2.1 1 0 0 1 1 1 1 DnaJ domain Potyvirid-P3 PF13608.6 ELR17899.1 - 0.12 11.3 0.1 0.23 10.5 0.1 1.4 1 0 0 1 1 1 0 Protein P3 of Potyviral polyprotein SHOCT PF09851.9 ELR17899.1 - 2.5 7.9 16.0 0.26 11.1 1.3 3.6 3 0 0 3 3 3 0 Short C-terminal domain MOSC_N PF03476.16 ELR17900.1 - 1e-29 102.8 0.0 1.8e-29 102.0 0.0 1.4 1 0 0 1 1 1 1 MOSC N-terminal beta barrel domain MOSC PF03473.17 ELR17900.1 - 1.7e-27 96.0 0.0 3e-27 95.2 0.0 1.3 1 0 0 1 1 1 1 MOSC domain MCM_OB PF17207.3 ELR17901.1 - 3.5e-25 88.3 0.5 5.5e-25 87.6 0.5 1.3 1 0 0 1 1 1 1 MCM OB domain NUFIP1 PF10453.9 ELR17902.1 - 2.8e-11 43.1 1.8 2.8e-11 43.1 1.8 1.9 2 0 0 2 2 2 1 Nuclear fragile X mental retardation-interacting protein 1 (NUFIP1) Keratin_2_head PF16208.5 ELR17902.1 - 3.2 7.9 16.9 4.3 7.5 16.9 1.1 1 0 0 1 1 1 0 Keratin type II head ARS2 PF04959.13 ELR17903.1 - 2.6 8.4 7.1 3.4 8.0 7.1 1.2 1 0 0 1 1 1 0 Arsenite-resistance protein 2 MCM PF00493.23 ELR17905.1 - 2.4e-88 295.0 0.0 3.5e-88 294.5 0.0 1.2 1 0 0 1 1 1 1 MCM P-loop domain MCM_lid PF17855.1 ELR17905.1 - 1.7e-27 95.6 2.3 3.2e-27 94.8 2.3 1.5 1 0 0 1 1 1 1 MCM AAA-lid domain Mg_chelatase PF01078.21 ELR17905.1 - 1.2e-09 37.9 0.0 1.1e-06 28.2 0.0 2.4 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 ELR17905.1 - 2.4e-07 30.9 0.0 5.5e-07 29.7 0.0 1.7 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.11 ELR17905.1 - 1.7e-06 27.9 0.0 5.2e-06 26.4 0.0 1.8 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 ELR17905.1 - 6.9e-06 25.9 0.0 1.6e-05 24.7 0.0 1.6 1 0 0 1 1 1 1 Sigma-54 interaction domain NTPase_1 PF03266.15 ELR17905.1 - 0.0012 18.8 0.1 0.2 11.6 0.0 2.8 3 0 0 3 3 3 1 NTPase AAA_16 PF13191.6 ELR17905.1 - 0.0012 19.3 0.5 0.015 15.7 0.1 2.7 2 1 1 3 3 3 1 AAA ATPase domain AAA PF00004.29 ELR17905.1 - 0.0058 17.0 0.0 0.031 14.7 0.0 2.4 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 ELR17905.1 - 0.0075 16.5 0.0 0.04 14.2 0.0 2.2 1 1 0 1 1 1 1 AAA domain RuvB_N PF05496.12 ELR17905.1 - 0.0083 15.9 0.0 0.047 13.4 0.0 2.2 1 1 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_29 PF13555.6 ELR17905.1 - 0.014 15.1 0.0 0.039 13.7 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_7 PF12775.7 ELR17905.1 - 0.029 13.9 0.0 0.14 11.7 0.0 2.0 2 0 0 2 2 2 0 P-loop containing dynein motor region RNA_helicase PF00910.22 ELR17905.1 - 0.034 14.5 0.1 49 4.4 0.0 3.3 3 0 0 3 3 3 0 RNA helicase FtsK_SpoIIIE PF01580.18 ELR17905.1 - 0.059 12.7 0.0 0.19 11.1 0.0 1.8 1 0 0 1 1 1 0 FtsK/SpoIIIE family NACHT PF05729.12 ELR17905.1 - 0.1 12.5 0.0 0.64 9.9 0.0 2.3 2 0 0 2 2 2 0 NACHT domain HECT PF00632.25 ELR17905.1 - 0.15 11.5 0.2 1.4 8.3 0.0 2.0 1 1 1 2 2 2 0 HECT-domain (ubiquitin-transferase) CsbD PF05532.12 ELR17906.1 - 0.00046 20.0 0.9 0.0014 18.5 0.9 1.8 1 0 0 1 1 1 1 CsbD-like VAPB_antitox PF02697.14 ELR17906.1 - 0.067 14.0 0.1 2 9.3 0.0 2.7 2 0 0 2 2 2 0 Putative antitoxin PI3_PI4_kinase PF00454.27 ELR17908.1 - 3.4e-07 30.3 0.0 3.6e-05 23.7 0.0 2.5 2 1 0 2 2 2 2 Phosphatidylinositol 3- and 4-kinase I-set PF07679.16 ELR17909.1 - 0.0022 18.0 0.0 0.0063 16.6 0.0 1.7 1 0 0 1 1 1 1 Immunoglobulin I-set domain JIP_LZII PF16471.5 ELR17909.1 - 0.0031 17.6 5.2 0.0031 17.6 5.2 10.9 8 4 4 14 14 14 3 JNK-interacting protein leucine zipper II Ig_3 PF13927.6 ELR17909.1 - 0.015 15.9 0.0 0.039 14.5 0.0 1.6 1 0 0 1 1 1 0 Immunoglobulin domain DUF4690 PF15756.5 ELR17910.1 - 0.0053 17.3 1.9 0.0068 17.0 1.0 1.7 1 1 0 1 1 1 1 Small Novel Rich in Cartilage EphA2_TM PF14575.6 ELR17910.1 - 0.017 16.0 0.1 0.08 13.8 0.1 2.0 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain DUF2516 PF10724.9 ELR17910.1 - 3 8.2 5.8 3.7 7.9 2.3 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2516) DUF3439 PF11921.8 ELR17912.1 - 0.027 14.5 5.5 0.053 13.5 5.5 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) PBP1_TM PF14812.6 ELR17912.1 - 0.26 11.7 11.9 0.18 12.2 9.3 2.0 2 1 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Sporozoite_P67 PF05642.11 ELR17912.1 - 2.6 6.0 8.3 4.2 5.3 8.3 1.3 1 0 0 1 1 1 0 Sporozoite P67 surface antigen PARP_reg PF02877.14 ELR17913.1 - 2.6e-43 147.4 0.2 7e-43 146.0 0.1 1.6 2 0 0 2 2 2 1 Poly(ADP-ribose) polymerase, regulatory domain DAGAT PF03982.13 ELR17915.1 - 3.4e-61 206.7 0.1 4.7e-61 206.3 0.1 1.1 1 0 0 1 1 1 1 Diacylglycerol acyltransferase HAD_2 PF13419.6 ELR17916.1 - 4.7e-19 69.2 0.1 4.1e-09 36.8 0.0 2.1 1 1 1 2 2 2 2 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 ELR17916.1 - 4.3e-10 40.3 2.2 2.3e-05 24.8 2.2 2.2 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 ELR17916.1 - 9.2e-05 22.4 0.1 0.00028 20.9 0.1 1.9 2 0 0 2 2 2 1 HAD-hyrolase-like SNARE PF05739.19 ELR17917.1 - 5.6e-15 55.1 0.2 3.4e-14 52.6 0.0 2.3 2 0 0 2 2 2 1 SNARE domain Syntaxin PF00804.25 ELR17917.1 - 0.00082 19.1 0.7 0.00082 19.1 0.7 2.9 3 1 0 3 3 3 1 Syntaxin LTXXQ PF07813.12 ELR17917.1 - 0.046 14.4 0.0 9.2 7.0 0.0 2.3 2 0 0 2 2 2 0 LTXXQ motif family protein Prominin PF05478.11 ELR17917.1 - 0.13 10.2 2.7 0.29 9.0 2.7 1.7 1 1 0 1 1 1 0 Prominin Syntaxin_2 PF14523.6 ELR17917.1 - 0.34 11.3 3.4 0.45 10.9 0.6 2.3 2 1 0 2 2 2 0 Syntaxin-like protein Osmo_CC PF08946.10 ELR17917.1 - 3.7 7.9 5.7 1.6 9.0 0.1 2.9 3 0 0 3 3 3 0 Osmosensory transporter coiled coil PCMT PF01135.19 ELR17918.1 - 1e-28 100.5 0.0 1.5e-25 90.2 0.0 2.2 2 0 0 2 2 2 2 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) BTB PF00651.31 ELR17918.1 - 4.3e-23 81.7 0.0 1.3e-22 80.1 0.0 1.9 1 1 0 1 1 1 1 BTB/POZ domain BACK PF07707.15 ELR17918.1 - 1.2e-05 25.4 0.1 6.2e-05 23.0 0.0 2.2 2 0 0 2 2 2 1 BTB And C-terminal Kelch DOT1 PF08123.13 ELR17918.1 - 0.015 14.9 0.0 0.029 13.9 0.0 1.4 1 0 0 1 1 1 0 Histone methylation protein DOT1 Methyltransf_25 PF13649.6 ELR17918.1 - 0.038 14.7 0.0 0.18 12.5 0.0 2.2 1 0 0 1 1 1 0 Methyltransferase domain CMAS PF02353.20 ELR17918.1 - 0.19 11.0 0.0 0.31 10.3 0.0 1.3 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase GTP_EFTU PF00009.27 ELR17919.1 - 8.3e-41 139.7 0.0 1.6e-40 138.7 0.0 1.5 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 ELR17919.1 - 6.1e-29 100.6 5.2 1e-28 99.9 0.2 3.1 3 0 0 3 3 3 1 Elongation factor Tu C-terminal domain MMR_HSR1 PF01926.23 ELR17919.1 - 7e-08 32.5 0.0 1.5e-06 28.3 0.0 2.6 1 1 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 ELR17919.1 - 0.00018 21.0 0.1 0.0063 16.0 0.1 2.7 2 1 0 2 2 2 1 Ferrous iron transport protein B GTP_EFTU_D2 PF03144.25 ELR17919.1 - 0.00021 21.6 0.2 0.00073 19.9 0.2 2.0 1 1 0 1 1 1 1 Elongation factor Tu domain 2 cobW PF02492.19 ELR17919.1 - 0.0046 16.6 2.0 0.28 10.7 0.0 3.3 3 0 0 3 3 3 1 CobW/HypB/UreG, nucleotide-binding domain G-alpha PF00503.20 ELR17919.1 - 0.0048 16.1 0.1 0.0087 15.3 0.1 1.3 1 0 0 1 1 1 1 G-protein alpha subunit ABC_tran PF00005.27 ELR17919.1 - 0.091 13.3 1.3 15 6.1 0.1 2.6 2 1 0 2 2 2 0 ABC transporter Dynamin_N PF00350.23 ELR17919.1 - 0.19 11.8 2.4 4.9 7.2 0.0 2.8 2 1 1 3 3 3 0 Dynamin family ATP_bind_1 PF03029.17 ELR17919.1 - 0.2 11.4 1.9 8 6.2 0.0 2.9 4 0 0 4 4 4 0 Conserved hypothetical ATP binding protein FDF PF09532.10 ELR17919.1 - 1.9 9.4 5.3 4.9 8.1 5.3 1.7 1 1 0 1 1 1 0 FDF domain Adaptin_binding PF10199.9 ELR17919.1 - 7.1 7.3 8.5 18 5.9 8.5 1.6 1 0 0 1 1 1 0 Alpha and gamma adaptin binding protein p34 Sec1 PF00995.23 ELR17920.1 - 1.4e-66 226.0 0.0 1.6e-66 225.7 0.0 1.1 1 0 0 1 1 1 1 Sec1 family DUF3455 PF11937.8 ELR17921.1 - 2.6e-23 83.2 0.5 3.9e-23 82.6 0.5 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3455) WD40 PF00400.32 ELR17922.1 - 2.1e-10 41.0 1.2 0.0067 17.2 0.0 4.5 4 0 0 4 4 4 2 WD domain, G-beta repeat LPP PF04728.13 ELR17922.1 - 0.038 14.4 0.4 0.083 13.3 0.4 1.5 1 0 0 1 1 1 0 Lipoprotein leucine-zipper PQQ_2 PF13360.6 ELR17922.1 - 0.049 13.2 0.0 0.095 12.3 0.0 1.4 1 0 0 1 1 1 0 PQQ-like domain DUF2383 PF09537.10 ELR17922.1 - 0.057 13.8 0.1 1.8 8.9 0.0 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF2383) PQQ_3 PF13570.6 ELR17922.1 - 0.13 12.8 0.0 1.4 9.5 0.0 2.5 2 1 0 2 2 2 0 PQQ-like domain DUF3450 PF11932.8 ELR17923.1 - 0.24 10.7 10.3 0.33 10.2 6.2 2.7 2 1 1 3 3 3 0 Protein of unknown function (DUF3450) YlqD PF11068.8 ELR17923.1 - 2.6 8.4 7.1 1 9.7 2.9 2.0 1 1 1 2 2 2 0 YlqD protein SAPS PF04499.15 ELR17924.1 - 1.9e-12 46.8 0.0 1.6e-05 23.9 0.0 2.1 2 0 0 2 2 2 2 SIT4 phosphatase-associated protein ELO PF01151.18 ELR17924.1 - 2.1e-12 47.1 0.0 4.1e-12 46.2 0.0 1.5 1 0 0 1 1 1 1 GNS1/SUR4 family HEAT_EZ PF13513.6 ELR17924.1 - 0.00043 20.7 1.9 2.1 9.0 0.1 3.7 4 0 0 4 4 4 2 HEAT-like repeat HEAT PF02985.22 ELR17924.1 - 0.0046 17.1 0.6 28 5.3 0.0 4.2 3 0 0 3 3 3 0 HEAT repeat Chordopox_A30L PF06015.12 ELR17924.1 - 0.057 13.3 0.3 16 5.4 0.0 2.5 2 0 0 2 2 2 0 Chordopoxvirus A30L protein DUF3263 PF11662.8 ELR17924.1 - 0.13 12.1 0.0 19 5.2 0.0 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3263) SMP PF04927.12 ELR17924.1 - 0.33 11.4 0.8 40 4.8 0.1 2.4 2 0 0 2 2 2 0 Seed maturation protein INCENP_ARK-bind PF03941.15 ELR17924.1 - 0.61 10.1 2.0 42 4.2 0.0 2.9 3 0 0 3 3 3 0 Inner centromere protein, ARK binding region ELO PF01151.18 ELR17925.1 - 2.9e-65 220.3 16.4 3.4e-65 220.0 16.4 1.0 1 0 0 1 1 1 1 GNS1/SUR4 family Col_cuticle_N PF01484.17 ELR17925.1 - 0.051 13.7 0.5 0.14 12.3 0.5 1.7 1 0 0 1 1 1 0 Nematode cuticle collagen N-terminal domain GRAM PF02893.20 ELR17926.1 - 1.6e-06 28.0 0.2 3.5e-06 26.9 0.0 1.7 2 0 0 2 2 2 1 GRAM domain Mitovir_RNA_pol PF05919.11 ELR17926.1 - 0.14 11.2 2.0 0.19 10.9 2.0 1.1 1 0 0 1 1 1 0 Mitovirus RNA-dependent RNA polymerase TaqI_C PF12950.7 ELR17926.1 - 0.15 12.1 0.8 0.27 11.3 0.8 1.4 1 0 0 1 1 1 0 TaqI-like C-terminal specificity domain Folliculin PF11704.8 ELR17926.1 - 1.8 8.4 8.6 23 4.8 8.6 2.2 1 1 0 1 1 1 0 Vesicle coat protein involved in Golgi to plasma membrane transport RabGAP-TBC PF00566.18 ELR17927.1 - 6.8e-53 179.5 0.7 6.8e-53 179.5 0.7 2.8 4 0 0 4 4 4 1 Rab-GTPase-TBC domain GRAM PF02893.20 ELR17927.1 - 2.9e-11 43.2 0.1 5.7e-11 42.3 0.1 1.5 1 0 0 1 1 1 1 GRAM domain UPF0270 PF06794.12 ELR17928.1 - 0.012 15.7 0.2 0.022 14.8 0.2 1.4 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0270) Vps51 PF08700.11 ELR17928.1 - 0.079 13.1 1.9 0.14 12.2 0.6 1.8 1 1 0 2 2 2 0 Vps51/Vps67 Fungal_TACC PF12709.7 ELR17928.1 - 0.65 10.5 5.7 0.27 11.7 1.1 2.0 1 1 1 2 2 2 0 Fungal Transforming acidic coiled-coil (TACC) proteins Myb_DNA-binding PF00249.31 ELR17930.1 - 3.6e-11 43.1 0.2 2.1e-08 34.2 0.0 2.6 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 ELR17930.1 - 0.00051 20.2 1.2 0.0023 18.2 0.0 2.6 3 1 0 3 3 3 1 Myb-like DNA-binding domain Inhibitor_I71 PF12628.7 ELR17930.1 - 0.37 10.6 4.7 0.91 9.3 1.0 2.4 2 0 0 2 2 2 0 Falstatin, cysteine peptidase inhibitor RNA_pol_Rpc4 PF05132.14 ELR17930.1 - 8 6.9 28.5 0.72 10.3 5.5 3.4 3 0 0 3 3 3 0 RNA polymerase III RPC4 DnaJ PF00226.31 ELR17932.1 - 3.9e-18 65.3 0.2 3.9e-18 65.3 0.2 2.0 2 0 0 2 2 2 1 DnaJ domain Myb_DNA-binding PF00249.31 ELR17932.1 - 1.2e-10 41.4 0.2 4.3e-08 33.2 0.0 2.8 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 ELR17932.1 - 0.00081 19.6 0.5 0.0048 17.1 0.0 2.7 3 0 0 3 3 3 1 Myb-like DNA-binding domain Inhibitor_I71 PF12628.7 ELR17932.1 - 1.8 8.4 3.9 1.9 8.3 0.9 2.3 2 0 0 2 2 2 0 Falstatin, cysteine peptidase inhibitor eIF-4B PF06273.11 ELR17933.1 - 0.0051 15.9 0.9 0.0051 15.9 0.9 6.7 2 2 4 6 6 6 1 Plant specific eukaryotic initiation factor 4B PI3_PI4_kinase PF00454.27 ELR17934.1 - 1.8e-51 175.3 0.0 2.1e-50 171.9 0.0 2.2 1 1 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase PI3Ka PF00613.20 ELR17934.1 - 2.4e-42 144.4 0.1 4.7e-42 143.5 0.1 1.4 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) PI3K_C2 PF00792.24 ELR17934.1 - 4.6e-13 49.3 0.0 8.7e-13 48.4 0.0 1.4 1 0 0 1 1 1 1 Phosphoinositide 3-kinase C2 PH PF00169.29 ELR17934.1 - 1.1e-10 41.9 0.1 4.1e-10 40.1 0.1 2.0 2 0 0 2 2 2 1 PH domain DUF4135 PF13575.6 ELR17934.1 - 0.0028 17.1 0.0 0.0049 16.2 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4135) HEAT_PBS PF03130.16 ELR17934.1 - 0.022 15.4 0.8 0.099 13.4 0.0 2.7 2 0 0 2 2 2 0 PBS lyase HEAT-like repeat C1_1 PF00130.22 ELR17934.1 - 0.041 13.8 2.8 0.09 12.7 2.8 1.5 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) K_channel_TID PF07941.11 ELR17934.1 - 0.096 13.2 2.0 0.25 11.8 2.0 1.6 1 0 0 1 1 1 0 Potassium channel Kv1.4 tandem inactivation domain DUF501 PF04417.12 ELR17935.1 - 0.025 14.4 1.0 0.63 9.8 0.0 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF501) CH PF00307.31 ELR17936.1 - 1.9e-31 108.5 0.1 3.3e-15 56.2 0.2 2.5 2 0 0 2 2 2 2 Calponin homology (CH) domain ER_lumen_recept PF00810.18 ELR17937.1 - 3.1e-59 200.0 8.8 3.1e-59 200.0 8.8 1.5 2 0 0 2 2 2 1 ER lumen protein retaining receptor PQ-loop PF04193.14 ELR17937.1 - 7.5 6.4 16.8 2.3 8.1 0.2 4.1 5 0 0 5 5 5 0 PQ loop repeat TFIIF_alpha PF05793.12 ELR17939.1 - 3.6 6.1 9.6 4.8 5.6 9.6 1.2 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) VHP PF02209.19 ELR17940.1 - 5.5e-13 48.8 0.2 1.8e-12 47.1 0.2 2.0 1 0 0 1 1 1 1 Villin headpiece domain Zip PF02535.22 ELR17941.1 - 0.064 12.5 1.3 0.078 12.2 1.3 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter CT47 PF15623.6 ELR17941.1 - 0.074 12.9 13.9 0.08 12.8 13.9 1.2 1 0 0 1 1 1 0 Cancer/testis gene family 47 NOA36 PF06524.12 ELR17941.1 - 0.14 11.4 2.5 0.17 11.2 2.5 1.1 1 0 0 1 1 1 0 NOA36 protein FAM176 PF14851.6 ELR17941.1 - 0.21 11.3 5.8 0.36 10.5 5.8 1.4 1 0 0 1 1 1 0 FAM176 family PAF PF15715.5 ELR17941.1 - 0.21 12.1 12.8 0.32 11.6 12.8 1.2 1 0 0 1 1 1 0 PCNA-associated factor histone like domain RNA_pol_Rbc25 PF08292.12 ELR17941.1 - 0.35 11.1 3.8 0.52 10.5 3.8 1.2 1 0 0 1 1 1 0 RNA polymerase III subunit Rpc25 TRAP_alpha PF03896.16 ELR17941.1 - 0.91 8.7 5.2 1.2 8.3 5.2 1.2 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit CDC27 PF09507.10 ELR17941.1 - 1.1 8.6 16.3 1.4 8.2 16.3 1.2 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 DUF4746 PF15928.5 ELR17941.1 - 4.9 6.5 14.5 6.2 6.2 14.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) SIT PF15330.6 ELR17941.1 - 8.6 6.8 6.6 13 6.2 2.1 2.1 2 0 0 2 2 2 0 SHP2-interacting transmembrane adaptor protein, SIT CDC45 PF02724.14 ELR17941.1 - 9.8 4.3 8.5 13 3.9 8.5 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF389 PF04087.14 ELR17942.1 - 6.7e-34 117.0 3.8 6.7e-34 117.0 3.8 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF389) DUF4781 PF16013.5 ELR17942.1 - 6.9 5.4 6.8 0.54 9.0 0.9 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4781) GIY-YIG PF01541.24 ELR17943.1 - 1.9e-13 50.5 0.1 3.2e-13 49.8 0.1 1.4 1 0 0 1 1 1 1 GIY-YIG catalytic domain zf-HC5HC2H PF13771.6 ELR17943.1 - 0.0048 17.1 3.3 0.0083 16.4 3.3 1.4 1 0 0 1 1 1 1 PHD-like zinc-binding domain zf-HC5HC2H_2 PF13832.6 ELR17943.1 - 0.0057 16.8 3.0 0.0096 16.1 3.0 1.3 1 0 0 1 1 1 1 PHD-zinc-finger like domain AF-4 PF05110.13 ELR17943.1 - 0.058 11.5 0.1 0.066 11.3 0.1 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein FANCL_C PF11793.8 ELR17943.1 - 0.12 12.6 4.5 0.19 11.9 4.5 1.3 1 0 0 1 1 1 0 FANCL C-terminal domain PHD PF00628.29 ELR17943.1 - 1.9 8.4 7.5 3.8 7.5 7.5 1.5 1 0 0 1 1 1 0 PHD-finger DNA_ligase_ZBD PF03119.16 ELR17943.1 - 2.9 8.0 6.0 12 6.0 0.3 2.6 2 0 0 2 2 2 0 NAD-dependent DNA ligase C4 zinc finger domain SAC3_GANP PF03399.16 ELR17944.1 - 8.2e-30 104.2 0.1 1.2e-29 103.6 0.1 1.1 1 0 0 1 1 1 1 SAC3/GANP family UcrQ PF02939.16 ELR17944.1 - 1.5e-13 50.4 0.2 4e-13 49.1 0.2 1.7 1 0 0 1 1 1 1 UcrQ family CSN8_PSD8_EIF3K PF10075.9 ELR17944.1 - 1.3e-07 31.7 0.0 2.7e-07 30.6 0.0 1.5 1 0 0 1 1 1 1 CSN8/PSMD8/EIF3K family Cyt_b-c1_8 PF10890.8 ELR17944.1 - 0.012 15.9 0.0 0.027 14.9 0.0 1.5 1 0 0 1 1 1 0 Cytochrome b-c1 complex subunit 8 ProQ PF04352.13 ELR17944.1 - 0.027 14.3 0.0 0.064 13.2 0.0 1.5 1 0 0 1 1 1 0 ProQ/FINO family TRAPPC-Trs85 PF12739.7 ELR17945.1 - 5.4e-51 173.8 0.0 1e-40 140.0 0.0 3.1 2 1 1 3 3 3 2 ER-Golgi trafficking TRAPP I complex 85 kDa subunit TRAPPC9-Trs120 PF08626.11 ELR17945.1 - 0.00011 19.8 0.0 0.00015 19.3 0.0 1.1 1 0 0 1 1 1 1 Transport protein Trs120 or TRAPPC9, TRAPP II complex subunit Aminotran_4 PF01063.19 ELR17946.1 - 2.7e-44 151.7 0.0 3.1e-44 151.5 0.0 1.0 1 0 0 1 1 1 1 Amino-transferase class IV DUF364 PF04016.12 ELR17946.1 - 0.029 14.0 0.0 0.18 11.4 0.0 2.1 2 0 0 2 2 2 0 Putative heavy-metal chelation Phosducin PF02114.16 ELR17947.1 - 1.2e-11 44.1 0.0 1.4e-11 43.8 0.0 1.1 1 0 0 1 1 1 1 Phosducin Thioredoxin PF00085.20 ELR17947.1 - 9.5e-05 22.3 0.0 0.00019 21.4 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin ACOX PF01756.19 ELR17948.1 - 6.2e-36 123.6 0.0 1.4e-35 122.5 0.0 1.6 1 0 0 1 1 1 1 Acyl-CoA oxidase Acyl-CoA_dh_M PF02770.19 ELR17948.1 - 2.9e-20 72.3 0.2 6.4e-20 71.2 0.1 1.7 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_1 PF00441.24 ELR17948.1 - 1.2e-09 38.6 0.1 3.6e-09 37.0 0.0 1.9 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain MlaC PF05494.12 ELR17948.1 - 0.016 15.0 0.5 0.032 14.0 0.5 1.5 1 0 0 1 1 1 0 MlaC protein ORF6N PF10543.9 ELR17948.1 - 0.028 14.6 0.0 0.087 13.0 0.0 1.8 1 0 0 1 1 1 0 ORF6N domain NDUF_B7 PF05676.13 ELR17949.1 - 2.1e-28 97.8 6.4 3.1e-28 97.3 6.4 1.3 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) Methyltransf_16 PF10294.9 ELR17950.1 - 1.4e-30 106.3 0.0 1.8e-30 105.9 0.0 1.1 1 0 0 1 1 1 1 Lysine methyltransferase PrmA PF06325.13 ELR17950.1 - 0.0044 16.4 0.0 0.0073 15.7 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.14 ELR17950.1 - 0.0054 16.3 0.1 0.012 15.2 0.0 1.5 2 0 0 2 2 2 1 Methyltransferase small domain PP2C PF00481.21 ELR17951.1 - 9.1e-61 205.7 0.0 1.2e-57 195.5 0.0 2.3 1 1 1 2 2 2 2 Protein phosphatase 2C PP2C_2 PF13672.6 ELR17951.1 - 0.00015 21.4 0.0 0.00048 19.8 0.0 1.9 2 1 0 2 2 2 1 Protein phosphatase 2C DUF21 PF01595.20 ELR17952.1 - 4.8e-34 117.6 1.4 1e-33 116.5 1.4 1.5 1 0 0 1 1 1 1 Cyclin M transmembrane N-terminal domain CBS PF00571.28 ELR17952.1 - 4.4e-06 27.1 3.3 0.0032 17.9 0.6 2.8 2 0 0 2 2 2 2 CBS domain LBP_BPI_CETP_C PF02886.17 ELR17953.1 - 9.3e-37 126.7 0.0 1.3e-36 126.2 0.0 1.2 1 0 0 1 1 1 1 LBP / BPI / CETP family, C-terminal domain LBP_BPI_CETP PF01273.25 ELR17953.1 - 2.9e-07 30.3 0.0 3.3e-06 26.8 0.0 2.3 1 1 0 1 1 1 1 LBP / BPI / CETP family, N-terminal domain ADP_ribosyl_GH PF03747.14 ELR17954.1 - 3.5e-37 128.7 2.9 7.3e-36 124.4 2.9 2.2 1 1 0 1 1 1 1 ADP-ribosylglycohydrolase FAM176 PF14851.6 ELR17954.1 - 0.014 15.0 2.4 0.23 11.1 0.0 2.3 2 0 0 2 2 2 0 FAM176 family Transgly_assoc PF04226.13 ELR17954.1 - 0.71 10.2 4.3 8.9 6.7 0.3 2.6 2 0 0 2 2 2 0 Transglycosylase associated protein YL1 PF05764.13 ELR17954.1 - 4.6 7.3 12.0 1.5 8.9 1.9 2.1 2 0 0 2 2 2 0 YL1 nuclear protein Nop14 PF04147.12 ELR17954.1 - 6.2 4.9 9.9 2 6.5 0.9 2.0 2 0 0 2 2 2 0 Nop14-like family Actin PF00022.19 ELR17955.1 - 5.5e-44 150.4 0.0 2.3e-22 79.2 0.0 2.5 2 1 0 2 2 2 2 Actin Nup188 PF10487.9 ELR17955.1 - 1.5 6.6 4.2 2.3 6.0 4.2 1.1 1 0 0 1 1 1 0 Nucleoporin subcomplex protein binding to Pom34 DUF334 PF03904.13 ELR17955.1 - 6.2 6.3 7.1 15 5.1 5.7 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF334) PRP1_N PF06424.12 ELR17957.1 - 9.6e-41 139.6 22.1 2.3e-39 135.1 22.1 3.4 1 1 0 1 1 1 1 PRP1 splicing factor, N-terminal TPR_14 PF13428.6 ELR17957.1 - 6.5e-32 107.5 36.6 8.4e-05 23.1 0.1 14.3 6 5 9 15 15 15 9 Tetratricopeptide repeat TPR_19 PF14559.6 ELR17957.1 - 1.3e-21 76.9 15.5 0.00098 19.6 0.4 9.9 6 3 4 10 10 10 5 Tetratricopeptide repeat TPR_16 PF13432.6 ELR17957.1 - 6.2e-08 33.2 16.3 0.18 12.5 0.0 6.9 5 1 0 6 6 6 2 Tetratricopeptide repeat TPR_2 PF07719.17 ELR17957.1 - 5e-07 29.4 15.0 1.3 9.3 0.0 10.2 13 0 0 13 13 11 2 Tetratricopeptide repeat TPR_11 PF13414.6 ELR17957.1 - 0.00015 21.3 1.7 28 4.5 0.0 6.8 7 1 1 8 8 8 0 TPR repeat TPR_17 PF13431.6 ELR17957.1 - 0.00016 21.9 6.0 83 3.9 0.0 9.0 9 2 0 10 10 10 0 Tetratricopeptide repeat Suf PF05843.14 ELR17957.1 - 0.00032 20.8 0.0 0.36 10.8 0.0 3.8 4 0 0 4 4 4 1 Suppressor of forked protein (Suf) TPR_8 PF13181.6 ELR17957.1 - 0.00069 19.6 0.3 46 4.6 0.0 6.6 8 0 0 8 8 7 0 Tetratricopeptide repeat Tcf25 PF04910.14 ELR17957.1 - 0.049 12.7 2.1 11 5.0 0.1 3.5 2 2 1 3 3 3 0 Transcriptional repressor TCF25 TPR_6 PF13174.6 ELR17957.1 - 0.19 12.4 0.0 0.19 12.4 0.0 7.7 10 0 0 10 10 8 0 Tetratricopeptide repeat ZNRF_3_ecto PF18212.1 ELR17957.1 - 0.51 10.4 2.3 6.3 6.8 0.0 3.8 5 2 1 6 6 6 0 ZNRF-3 Ectodomain TPR_10 PF13374.6 ELR17957.1 - 8.9 6.3 8.2 6.1 6.9 0.3 4.4 5 0 0 5 5 5 0 Tetratricopeptide repeat DUF2715 PF10895.8 ELR17958.1 - 0.0068 16.1 1.9 0.012 15.2 1.9 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF2715) DUF3956 PF13104.6 ELR17958.1 - 0.21 11.8 0.0 0.21 11.8 0.0 3.8 5 0 0 5 5 5 0 Protein of unknown function (DUF3956) Pkinase_Tyr PF07714.17 ELR17959.1 - 2.6e-49 167.8 0.0 3.9e-49 167.3 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ELR17959.1 - 4.3e-48 164.0 0.0 6.4e-48 163.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Haspin_kinase PF12330.8 ELR17959.1 - 0.019 14.0 0.0 0.03 13.3 0.0 1.2 1 0 0 1 1 1 0 Haspin like kinase domain APH PF01636.23 ELR17959.1 - 0.059 13.3 0.0 0.11 12.4 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family TRAM_LAG1_CLN8 PF03798.16 ELR17960.1 - 3.2e-26 92.3 22.3 3.2e-26 92.3 22.3 2.1 1 1 0 2 2 2 1 TLC domain TRAM1 PF08390.11 ELR17960.1 - 0.0088 15.7 1.3 0.022 14.4 0.1 2.3 2 0 0 2 2 2 1 TRAM1-like protein EF-hand_7 PF13499.6 ELR17961.1 - 5.9e-12 45.9 2.3 2.8e-07 30.9 0.6 2.7 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 ELR17961.1 - 1.1e-11 43.4 0.1 3.2e-05 23.2 0.1 2.8 2 0 0 2 2 2 2 EF hand EF-hand_5 PF13202.6 ELR17961.1 - 6.1e-11 41.3 0.5 0.00029 20.2 0.3 2.6 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 ELR17961.1 - 1.5e-09 37.0 0.3 0.00013 21.6 0.1 3.0 3 0 0 3 3 3 2 EF-hand domain EF-hand_8 PF13833.6 ELR17961.1 - 6e-07 29.2 0.1 0.00077 19.3 0.0 2.6 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_4 PF12763.7 ELR17961.1 - 0.089 12.8 0.1 2.8 7.9 0.0 2.3 2 0 0 2 2 2 0 Cytoskeletal-regulatory complex EF hand dCache_1 PF02743.18 ELR17961.1 - 0.12 12.1 0.0 0.21 11.4 0.0 1.3 1 0 0 1 1 1 0 Cache domain MCM PF00493.23 ELR17962.1 - 3.9e-98 327.0 0.0 6.1e-98 326.4 0.0 1.3 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 ELR17962.1 - 1.8e-37 128.0 0.1 3e-37 127.3 0.1 1.4 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 ELR17962.1 - 1.7e-26 92.5 0.9 4.9e-26 91.0 0.3 2.2 2 0 0 2 2 2 1 MCM AAA-lid domain MCM2_N PF12619.8 ELR17962.1 - 2.6e-18 66.8 17.0 2.6e-18 66.8 17.0 1.9 2 0 0 2 2 2 1 Mini-chromosome maintenance protein 2 MCM_N PF14551.6 ELR17962.1 - 8.4e-14 52.0 0.0 3.4e-13 50.1 0.0 2.1 1 0 0 1 1 1 1 MCM N-terminal domain Mg_chelatase PF01078.21 ELR17962.1 - 1.2e-08 34.6 0.0 6e-07 29.0 0.0 2.7 2 1 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 ELR17962.1 - 9.5e-06 25.7 0.0 3.7e-05 23.8 0.0 2.1 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.11 ELR17962.1 - 0.0019 18.1 0.0 0.0063 16.4 0.0 1.9 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_lid_2 PF17863.1 ELR17962.1 - 0.0044 16.8 0.2 0.016 15.0 0.1 2.0 2 0 0 2 2 2 1 AAA lid domain Sigma54_activat PF00158.26 ELR17962.1 - 0.014 15.1 0.1 0.13 12.0 0.1 2.3 1 1 0 1 1 1 0 Sigma-54 interaction domain PQQ_2 PF13360.6 ELR17963.1 - 1.6e-08 34.4 0.1 9e-05 22.2 0.0 2.7 2 1 0 3 3 3 2 PQQ-like domain PQQ_3 PF13570.6 ELR17963.1 - 2.5e-06 27.8 21.7 0.19 12.3 0.3 7.1 6 1 1 7 7 7 4 PQQ-like domain NCD3G PF07562.14 ELR17963.1 - 0.00013 21.9 8.5 0.045 13.7 0.2 2.6 1 1 0 2 2 2 2 Nine Cysteines Domain of family 3 GPCR Ephrin_rec_like PF07699.13 ELR17963.1 - 0.00041 20.0 19.3 0.00084 19.0 4.8 3.1 1 1 1 2 2 2 1 Putative ephrin-receptor like F-box-like PF12937.7 ELR17964.1 - 9.2e-06 25.5 0.0 2.2e-05 24.3 0.0 1.7 1 0 0 1 1 1 1 F-box-like DUF4618 PF15397.6 ELR17965.1 - 0.012 15.0 1.7 0.012 15.0 1.7 4.7 2 1 4 6 6 6 0 Domain of unknown function (DUF4618) SNARE PF05739.19 ELR17966.1 - 1.1e-13 50.9 0.6 1.1e-13 50.9 0.6 2.4 2 0 0 2 2 2 1 SNARE domain Syntaxin PF00804.25 ELR17966.1 - 4.6e-07 29.7 11.9 0.00014 21.6 0.5 2.3 2 0 0 2 2 2 2 Syntaxin Cep3 PF16846.5 ELR17966.1 - 0.00037 19.1 2.3 0.00037 19.1 2.3 1.6 2 0 0 2 2 2 1 Centromere DNA-binding protein complex CBF3 subunit B Syntaxin-5_N PF11416.8 ELR17966.1 - 0.00054 19.1 0.0 0.0015 17.7 0.0 1.8 1 0 0 1 1 1 1 Syntaxin-5 N-terminal, Sly1p-binding domain SKA1 PF07160.12 ELR17966.1 - 0.0022 17.9 13.4 0.16 11.8 3.7 2.3 2 0 0 2 2 2 2 Spindle and kinetochore-associated protein 1 zf-XS PF03470.14 ELR17966.1 - 0.083 13.2 0.2 0.4 11.0 0.0 2.1 2 0 0 2 2 2 0 XS zinc finger domain LicD PF04991.13 ELR17966.1 - 0.18 11.9 2.7 0.41 10.8 2.7 1.5 1 0 0 1 1 1 0 LicD family ArsC PF03960.15 ELR17966.1 - 0.21 11.6 0.8 4.1 7.5 0.0 2.6 1 1 1 2 2 2 0 ArsC family HD_4 PF13328.6 ELR17966.1 - 0.3 10.8 4.0 0.2 11.4 1.6 2.0 2 1 0 2 2 2 0 HD domain Retrotran_gag_2 PF14223.6 ELR17966.1 - 0.35 10.5 7.9 5.7 6.6 0.2 2.3 2 0 0 2 2 2 0 gag-polypeptide of LTR copia-type AI-2E_transport PF01594.16 ELR17966.1 - 1.4 8.0 9.9 0.047 12.8 2.9 1.9 2 1 0 2 2 2 0 AI-2E family transporter Collagen_mid PF15984.5 ELR17966.1 - 2 8.1 6.9 13 5.4 0.1 2.6 2 1 0 2 2 2 0 Bacterial collagen, middle region Allexi_40kDa PF05549.11 ELR17966.1 - 2.1 7.8 11.5 0.61 9.5 5.5 2.2 2 1 0 2 2 2 0 Allexivirus 40kDa protein NPV_P10 PF05531.12 ELR17966.1 - 2.9 8.4 12.1 0.1 13.1 1.9 3.0 2 1 1 3 3 3 0 Nucleopolyhedrovirus P10 protein DUF1664 PF07889.12 ELR17966.1 - 3.4 7.7 14.9 1.5 8.8 3.1 3.2 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) Syntaxin-6_N PF09177.11 ELR17966.1 - 3.4 8.3 11.2 5.2 7.7 5.9 3.1 2 2 1 3 3 3 0 Syntaxin 6, N-terminal DUF724 PF05266.14 ELR17966.1 - 7.8 6.3 13.9 5.2 6.9 6.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF724) Epimerase PF01370.21 ELR17967.1 - 3.7e-25 88.8 0.0 4.9e-25 88.4 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 ELR17967.1 - 1.1e-10 41.7 0.0 2.5e-10 40.6 0.0 1.5 1 1 0 1 1 1 1 NAD(P)H-binding RmlD_sub_bind PF04321.17 ELR17967.1 - 2.4e-10 40.0 0.0 3.6e-10 39.4 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain GDP_Man_Dehyd PF16363.5 ELR17967.1 - 3.6e-10 39.8 0.0 4.8e-10 39.3 0.0 1.2 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase 3Beta_HSD PF01073.19 ELR17967.1 - 9e-09 34.7 0.0 3e-08 33.0 0.0 1.8 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Polysacc_synt_2 PF02719.15 ELR17967.1 - 6.8e-05 22.1 0.4 0.00012 21.3 0.1 1.5 2 0 0 2 2 2 1 Polysaccharide biosynthesis protein NAD_binding_4 PF07993.12 ELR17967.1 - 0.001 18.3 1.8 1.5 8.0 0.0 3.0 2 1 0 2 2 2 2 Male sterility protein Semialdhyde_dh PF01118.24 ELR17967.1 - 0.1 13.0 0.1 0.32 11.4 0.0 1.9 2 0 0 2 2 2 0 Semialdehyde dehydrogenase, NAD binding domain NmrA PF05368.13 ELR17967.1 - 0.13 11.8 0.1 1.7 8.2 0.0 2.4 2 1 0 2 2 2 0 NmrA-like family Abhydro_lipase PF04083.16 ELR17968.1 - 3.9e-18 64.8 0.1 1.3e-17 63.1 0.0 1.9 2 0 0 2 2 2 1 Partial alpha/beta-hydrolase lipase region Abhydrolase_1 PF00561.20 ELR17968.1 - 1.1e-12 48.1 0.2 4.3e-09 36.4 0.1 2.2 2 0 0 2 2 2 2 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 ELR17968.1 - 1.2e-06 27.9 0.4 0.00032 20.0 0.1 2.2 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 ELR17968.1 - 0.0016 19.0 0.1 0.0035 18.0 0.1 1.6 1 1 0 1 1 1 1 Alpha/beta hydrolase family DUF1749 PF08538.10 ELR17968.1 - 0.045 12.8 0.0 0.074 12.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1749) DUF3089 PF11288.8 ELR17968.1 - 0.18 11.4 0.0 0.26 10.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3089) DUF563 PF04577.14 ELR17969.1 - 3.2e-20 73.2 0.1 5e-20 72.5 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF563) PQQ_2 PF13360.6 ELR17970.1 - 0.00026 20.6 1.2 0.00059 19.5 0.1 2.1 2 0 0 2 2 2 1 PQQ-like domain WD40 PF00400.32 ELR17970.1 - 0.052 14.4 2.5 1.7 9.7 0.5 4.2 5 0 0 5 5 5 0 WD domain, G-beta repeat Aldedh PF00171.22 ELR17972.1 - 3e-77 260.1 0.0 4.6e-77 259.5 0.0 1.2 1 0 0 1 1 1 1 Aldehyde dehydrogenase family SART-1 PF03343.13 ELR17972.1 - 0.0021 16.7 12.1 0.0032 16.1 12.1 1.2 1 0 0 1 1 1 1 SART-1 family Pox_Ag35 PF03286.14 ELR17972.1 - 0.15 11.9 11.6 0.29 10.9 11.6 1.5 1 0 0 1 1 1 0 Pox virus Ag35 surface protein MMM1 PF10296.9 ELR17972.1 - 1 8.4 2.8 1.6 7.7 2.8 1.2 1 0 0 1 1 1 0 Maintenance of mitochondrial morphology protein 1 Spore_coat_CotO PF14153.6 ELR17972.1 - 1.4 8.8 9.8 1.6 8.6 8.8 1.6 2 0 0 2 2 2 0 Spore coat protein CotO CDC27 PF09507.10 ELR17972.1 - 1.6 8.1 18.0 2.6 7.3 18.0 1.3 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 NPR3 PF03666.13 ELR17972.1 - 1.6 7.4 9.7 2.3 6.9 9.7 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 RNA_pol_3_Rpc31 PF11705.8 ELR17972.1 - 8 6.6 21.4 15 5.8 21.4 1.3 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 PAS PF00989.25 ELR17976.1 - 9.9e-09 35.2 0.0 1.6e-08 34.6 0.0 1.4 1 0 0 1 1 1 1 PAS fold PAS_9 PF13426.7 ELR17976.1 - 3.8e-05 23.9 0.0 6.6e-05 23.1 0.0 1.4 1 0 0 1 1 1 1 PAS domain PAS_4 PF08448.10 ELR17976.1 - 0.0016 18.7 0.0 0.0028 17.9 0.0 1.5 1 0 0 1 1 1 1 PAS fold DUF1180 PF06679.12 ELR17976.1 - 0.043 14.2 0.2 0.057 13.8 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) TSC22 PF01166.18 ELR17976.1 - 0.098 13.0 0.1 0.18 12.1 0.1 1.3 1 0 0 1 1 1 0 TSC-22/dip/bun family PAS_10 PF13596.6 ELR17976.1 - 0.11 13.1 0.0 0.19 12.3 0.0 1.4 1 0 0 1 1 1 0 PAS domain MFS_1_like PF12832.7 ELR17977.1 - 1e-49 169.5 15.1 4.3e-39 134.5 16.0 2.0 1 1 1 2 2 2 2 MFS_1 like family MFS_1 PF07690.16 ELR17977.1 - 9.3e-15 54.4 48.5 6.7e-11 41.7 25.5 3.0 1 1 2 3 3 3 2 Major Facilitator Superfamily LacY_symp PF01306.19 ELR17977.1 - 1.3e-10 40.6 5.6 2.3e-08 33.2 5.6 2.8 1 1 0 1 1 1 1 LacY proton/sugar symporter MFS_2 PF13347.6 ELR17977.1 - 0.0025 16.4 13.2 0.0025 16.4 13.2 2.6 2 1 1 3 3 3 1 MFS/sugar transport protein HpaB_N PF11794.8 ELR17978.1 - 0.025 14.3 0.0 0.61 9.7 0.0 2.4 3 0 0 3 3 3 0 4-hydroxyphenylacetate 3-hydroxylase N terminal Abhydrolase_6 PF12697.7 ELR17979.1 - 1.1e-18 68.7 0.2 1.4e-18 68.4 0.2 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 ELR17979.1 - 7.3e-16 58.6 0.1 1.6e-15 57.4 0.1 1.5 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 ELR17979.1 - 7.3e-11 41.8 0.0 9.8e-11 41.4 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 AAA_2 PF07724.14 ELR17980.1 - 1.6e-05 25.1 0.2 2.6e-05 24.4 0.2 1.3 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.6 ELR17980.1 - 2.2e-05 24.8 1.6 0.00034 20.9 0.5 2.7 3 1 0 3 3 3 1 AAA domain Torsin PF06309.11 ELR17980.1 - 5.7e-05 23.2 0.0 0.00012 22.2 0.0 1.5 1 0 0 1 1 1 1 Torsin AAA PF00004.29 ELR17980.1 - 0.0017 18.8 0.0 0.0035 17.8 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 ELR17980.1 - 0.0029 18.0 0.1 0.073 13.4 0.0 2.4 2 1 1 3 3 3 1 AAA ATPase domain AAA_5 PF07728.14 ELR17980.1 - 0.021 14.8 0.1 0.14 12.2 0.1 2.2 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_30 PF13604.6 ELR17980.1 - 0.086 12.6 0.0 0.15 11.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain DNA_pol3_delta2 PF13177.6 ELR17980.1 - 0.24 11.1 0.7 0.78 9.5 0.7 1.9 1 1 0 1 1 1 0 DNA polymerase III, delta subunit Peripla_BP_6 PF13458.6 ELR17981.1 - 8.4e-63 213.1 15.8 7.2e-37 127.8 5.1 2.6 3 0 0 3 3 3 2 Periplasmic binding protein ANF_receptor PF01094.28 ELR17981.1 - 1.1e-20 74.1 0.3 4.5e-11 42.4 0.0 2.2 2 0 0 2 2 2 2 Receptor family ligand binding region Peripla_BP_5 PF13433.6 ELR17981.1 - 0.00017 20.7 0.4 0.0046 16.0 0.1 2.2 2 0 0 2 2 2 1 Periplasmic binding protein domain COesterase PF00135.28 ELR17982.1 - 8.8e-09 34.8 0.0 1e-08 34.5 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family COesterase PF00135.28 ELR17983.1 - 6.9e-81 272.7 1.5 8.7e-81 272.3 1.5 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 ELR17983.1 - 1.4e-09 38.1 0.8 1.1e-08 35.2 0.8 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold Say1_Mug180 PF10340.9 ELR17983.1 - 0.0016 17.4 0.0 0.012 14.5 0.0 2.0 1 1 0 1 1 1 1 Steryl acetyl hydrolase Esterase PF00756.20 ELR17983.1 - 0.0088 15.7 0.2 0.015 14.9 0.2 1.4 1 0 0 1 1 1 1 Putative esterase Peptidase_S9 PF00326.21 ELR17983.1 - 0.059 12.8 0.0 0.1 12.1 0.0 1.4 1 0 0 1 1 1 0 Prolyl oligopeptidase family COesterase PF00135.28 ELR17984.1 - 5.8e-37 127.7 0.2 8.1e-37 127.3 0.2 1.2 1 0 0 1 1 1 1 Carboxylesterase family Arm_vescicular PF18770.1 ELR17985.1 - 0.0097 15.8 1.3 6.2 6.8 0.0 2.5 2 0 0 2 2 2 2 Armadillo tether-repeat of vescicular transport factor Aldo_ket_red PF00248.21 ELR17986.1 - 3e-19 69.3 0.0 1.8e-16 60.2 0.0 2.3 2 0 0 2 2 2 2 Aldo/keto reductase family HMW1C_N PF18071.1 ELR17987.1 - 0.096 12.5 0.7 11 5.8 0.1 2.3 2 1 0 2 2 2 0 HMW1C N-terminal DUF349 PF03993.12 ELR17987.1 - 0.16 12.2 3.5 6.8 7.1 0.3 2.3 2 0 0 2 2 2 0 Domain of Unknown Function (DUF349) RNase_H2-Ydr279 PF09468.10 ELR17987.1 - 0.23 11.6 1.9 0.3 11.3 0.8 1.7 1 1 1 2 2 2 0 Ydr279p protein family (RNase H2 complex component) wHTH domain HSCB_C PF07743.13 ELR17987.1 - 0.52 10.8 5.5 0.51 10.9 0.2 2.4 2 1 0 2 2 2 0 HSCB C-terminal oligomerisation domain RasGEF PF00617.19 ELR17988.1 - 3.7e-44 151.0 0.0 6.5e-44 150.2 0.0 1.3 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 ELR17988.1 - 8e-05 22.8 0.8 0.027 14.7 0.4 3.2 2 1 0 2 2 2 1 RasGEF N-terminal motif EI24 PF07264.11 ELR17989.1 - 0.00015 22.1 31.3 0.0005 20.4 1.8 3.0 2 1 1 3 3 3 2 Etoposide-induced protein 2.4 (EI24) RFX_DNA_binding PF02257.15 ELR17990.1 - 5.8e-13 49.3 0.1 1.2e-12 48.3 0.1 1.5 1 0 0 1 1 1 1 RFX DNA-binding domain Gelsolin PF00626.22 ELR17990.1 - 1.1e-10 41.3 0.0 2.8e-10 40.0 0.0 1.7 1 0 0 1 1 1 1 Gelsolin repeat LRR_8 PF13855.6 ELR17990.1 - 0.00014 21.5 0.4 0.00028 20.6 0.4 1.4 1 0 0 1 1 1 1 Leucine rich repeat LRR_4 PF12799.7 ELR17990.1 - 0.019 15.4 1.4 0.043 14.3 1.4 1.6 1 0 0 1 1 1 0 Leucine Rich repeats (2 copies) NOA36 PF06524.12 ELR17990.1 - 0.11 11.8 1.9 0.19 11.0 1.9 1.3 1 0 0 1 1 1 0 NOA36 protein DUF4349 PF14257.6 ELR17991.1 - 0.0025 17.3 1.6 0.0031 17.0 1.6 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4349) LMBR1 PF04791.16 ELR17991.1 - 0.0029 16.6 0.4 0.003 16.5 0.4 1.0 1 0 0 1 1 1 1 LMBR1-like membrane protein Syntaxin PF00804.25 ELR17991.1 - 0.0041 16.8 0.5 0.0069 16.1 0.5 1.5 1 0 0 1 1 1 1 Syntaxin Prominin PF05478.11 ELR17991.1 - 0.0049 14.9 1.1 0.0056 14.7 1.1 1.0 1 0 0 1 1 1 1 Prominin ENOD93 PF03386.14 ELR17991.1 - 0.0059 16.5 4.9 0.0078 16.1 4.9 1.2 1 0 0 1 1 1 1 Early nodulin 93 ENOD93 protein DUF2207 PF09972.9 ELR17991.1 - 0.0088 14.9 0.2 0.0092 14.8 0.2 1.0 1 0 0 1 1 1 1 Predicted membrane protein (DUF2207) V-SNARE PF05008.15 ELR17991.1 - 0.019 15.3 0.6 0.03 14.7 0.6 1.4 1 0 0 1 1 1 0 Vesicle transport v-SNARE protein N-terminus Tweety PF04906.13 ELR17991.1 - 0.023 13.4 2.3 0.026 13.2 2.3 1.0 1 0 0 1 1 1 0 Tweety MscS_porin PF12795.7 ELR17991.1 - 0.047 13.2 0.1 0.052 13.1 0.1 1.1 1 0 0 1 1 1 0 Mechanosensitive ion channel porin domain RIFIN PF02009.16 ELR17991.1 - 0.11 12.3 4.8 0.13 12.1 4.8 1.1 1 0 0 1 1 1 0 Rifin SNARE PF05739.19 ELR17991.1 - 0.12 12.3 9.0 0.58 10.2 9.0 2.0 1 1 0 1 1 1 0 SNARE domain DUF3671 PF12420.8 ELR17991.1 - 0.52 10.4 4.2 0.16 12.1 0.5 1.9 2 0 0 2 2 2 0 Protein of unknown function Ferlin_C PF16165.5 ELR17991.1 - 1.5 8.8 5.1 2.1 8.3 5.1 1.5 1 1 0 1 1 1 0 Ferlin C-terminus Synaptobrevin PF00957.21 ELR17991.1 - 1.9 8.3 8.4 3.3 7.6 8.4 1.4 1 1 0 1 1 1 0 Synaptobrevin PsbX PF06596.11 ELR17991.1 - 5.9 7.0 10.3 10 6.2 10.3 1.4 1 0 0 1 1 1 0 Photosystem II reaction centre X protein (PsbX) RRM_1 PF00076.22 ELR17992.1 - 1.5e-22 79.1 0.0 2e-22 78.8 0.0 1.1 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 ELR17992.1 - 0.00044 20.3 0.0 0.00067 19.7 0.0 1.3 1 1 0 1 1 1 1 RNA recognition motif HSP20 PF00011.21 ELR17993.1 - 2e-15 56.8 0.0 3.1e-15 56.2 0.0 1.2 1 0 0 1 1 1 1 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 ELR17993.1 - 4e-09 35.9 0.0 9.8e-09 34.6 0.0 1.7 2 0 0 2 2 2 1 HSP20-like domain found in ArsA DUF2374 PF09574.10 ELR17993.1 - 2 8.3 8.1 21 5.1 0.3 3.5 3 0 0 3 3 3 0 Protein of unknown function (Duf2374) HSP20 PF00011.21 ELR17994.1 - 8.5e-12 45.1 0.0 1.4e-11 44.4 0.0 1.2 1 0 0 1 1 1 1 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 ELR17994.1 - 1.3e-06 27.8 0.0 2.3e-06 27.0 0.0 1.4 1 0 0 1 1 1 1 HSP20-like domain found in ArsA Chorion_1 PF01723.16 ELR17994.1 - 0.6 10.1 8.7 5.2 7.0 2.1 2.1 1 1 1 2 2 2 0 Chorion protein Gln-synt_C PF00120.24 ELR17995.1 - 1.8e-05 23.9 0.0 2.1e-05 23.7 0.0 1.0 1 0 0 1 1 1 1 Glutamine synthetase, catalytic domain MerC PF03203.14 ELR17996.1 - 5.6 7.4 8.2 2.6 8.5 2.3 2.7 2 1 0 2 2 2 0 MerC mercury resistance protein FAD_binding_3 PF01494.19 ELR17997.1 - 2.5e-07 30.3 0.6 0.0014 17.9 0.0 2.5 3 0 0 3 3 3 2 FAD binding domain EF-hand_7 PF13499.6 ELR17997.1 - 5.8e-05 23.5 3.2 0.023 15.2 3.1 2.8 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 ELR17997.1 - 0.00049 19.8 1.6 0.14 12.1 0.0 3.4 3 1 1 4 4 4 1 EF-hand domain Pyr_redox_2 PF07992.14 ELR17997.1 - 0.006 15.9 0.0 0.011 15.0 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase EF-hand_1 PF00036.32 ELR17997.1 - 0.0064 16.0 0.1 0.13 11.9 0.0 2.8 2 0 0 2 2 2 1 EF hand FAD_binding_2 PF00890.24 ELR17997.1 - 0.0076 15.4 0.0 0.014 14.5 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain EF-hand_8 PF13833.6 ELR17997.1 - 0.022 14.6 3.1 0.14 12.0 0.0 3.3 4 1 0 4 4 4 0 EF-hand domain pair Pyr_redox_3 PF13738.6 ELR17997.1 - 0.034 13.4 0.0 0.057 12.7 0.0 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 ELR17997.1 - 0.12 12.6 0.1 0.32 11.3 0.1 1.7 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.14 ELR17997.1 - 0.13 10.9 0.0 0.27 9.9 0.0 1.5 1 0 0 1 1 1 0 HI0933-like protein Pur_ac_phosph_N PF16656.5 ELR17998.1 - 2.8e-17 63.0 0.6 1.1e-16 61.2 0.2 2.1 2 0 0 2 2 2 1 Purple acid Phosphatase, N-terminal domain Metallophos_C PF14008.6 ELR17998.1 - 3.7e-13 50.1 0.0 1.2e-12 48.5 0.0 1.9 1 0 0 1 1 1 1 Iron/zinc purple acid phosphatase-like protein C Metallophos PF00149.28 ELR17998.1 - 1.6e-12 48.4 1.9 5.1e-12 46.7 1.9 1.8 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase SapB_2 PF03489.17 ELR17998.1 - 0.0022 18.1 0.0 0.0043 17.1 0.0 1.5 1 0 0 1 1 1 1 Saposin-like type B, region 2 PhoD_N PF16655.5 ELR17998.1 - 0.0027 18.2 0.0 0.0071 16.9 0.0 1.7 1 0 0 1 1 1 1 PhoD-like phosphatase, N-terminal domain Metallophos_2 PF12850.7 ELR17998.1 - 0.0045 17.2 0.0 0.35 11.0 0.0 2.3 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase superfamily domain SapB_1 PF05184.15 ELR17998.1 - 0.0094 16.0 0.2 0.022 14.8 0.2 1.6 1 0 0 1 1 1 1 Saposin-like type B, region 1 PhoD PF09423.10 ELR17998.1 - 0.062 12.3 0.1 5 6.0 0.0 2.1 2 0 0 2 2 2 0 PhoD-like phosphatase DUF1764 PF08576.10 ELR17999.1 - 0.36 11.7 3.7 0.43 11.5 3.7 1.1 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF1764) Bap31_Bap29_C PF18035.1 ELR17999.1 - 1.4 8.9 6.8 3 7.9 3.6 2.1 2 0 0 2 2 2 0 Bap31/Bap29 cytoplasmic coiled-coil domain Gln-synt_C PF00120.24 ELR18000.1 - 1.8e-05 23.9 0.0 2.1e-05 23.7 0.0 1.0 1 0 0 1 1 1 1 Glutamine synthetase, catalytic domain Turandot PF07240.11 ELR18001.1 - 0.18 11.8 1.2 0.2 11.7 0.1 1.6 2 0 0 2 2 2 0 Stress-inducible humoral factor Turandot MerC PF03203.14 ELR18001.1 - 3.8 8.0 8.9 0.49 10.9 2.4 2.5 2 1 0 2 2 2 0 MerC mercury resistance protein Adeno_PV PF03910.13 ELR18001.1 - 8.9 4.9 6.8 6.9 5.3 0.4 2.4 2 0 0 2 2 2 0 Adenovirus minor core protein PV NHL PF01436.21 ELR18002.1 - 2.6e-07 30.3 0.1 8e-07 28.8 0.0 1.9 2 0 0 2 2 1 1 NHL repeat SlyX PF04102.12 ELR18002.1 - 0.00059 20.4 3.7 0.00093 19.8 3.7 1.3 1 0 0 1 1 1 1 SlyX DivIC PF04977.15 ELR18002.1 - 0.0013 18.5 2.9 0.0018 18.0 2.9 1.2 1 0 0 1 1 1 1 Septum formation initiator HrpB7 PF09486.10 ELR18002.1 - 0.0025 18.2 0.5 0.0025 18.2 0.5 1.6 2 0 0 2 2 2 1 Bacterial type III secretion protein (HrpB7) FliD_N PF02465.18 ELR18002.1 - 0.0029 18.2 0.9 0.0057 17.3 0.9 1.5 1 0 0 1 1 1 1 Flagellar hook-associated protein 2 N-terminus Spc29 PF17082.5 ELR18002.1 - 0.0036 17.2 0.0 0.0047 16.8 0.0 1.1 1 0 0 1 1 1 1 Spindle Pole Component 29 DUF2681 PF10883.8 ELR18002.1 - 0.0044 17.4 1.3 0.0075 16.7 1.3 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2681) USP8_interact PF08941.10 ELR18002.1 - 0.0048 16.7 3.1 0.0066 16.3 3.1 1.1 1 0 0 1 1 1 1 USP8 interacting HAP1_N PF04849.13 ELR18002.1 - 0.006 15.8 2.1 0.0079 15.4 2.1 1.1 1 0 0 1 1 1 1 HAP1 N-terminal conserved region CENP-Q PF13094.6 ELR18002.1 - 0.01 16.1 0.7 0.014 15.6 0.7 1.1 1 0 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit PspA_IM30 PF04012.12 ELR18002.1 - 0.012 15.2 3.2 0.015 14.8 3.2 1.1 1 0 0 1 1 1 0 PspA/IM30 family Lebercilin PF15619.6 ELR18002.1 - 0.017 14.8 4.0 0.024 14.3 4.0 1.1 1 0 0 1 1 1 0 Ciliary protein causing Leber congenital amaurosis disease DUF4340 PF14238.6 ELR18002.1 - 0.027 14.5 0.1 0.04 13.9 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4340) Spc7 PF08317.11 ELR18002.1 - 0.042 12.7 1.1 0.049 12.5 1.1 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF3509 PF12021.8 ELR18002.1 - 0.048 13.4 2.2 0.071 12.9 2.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3509) AbiJ_NTD5 PF18865.1 ELR18002.1 - 0.16 11.8 0.1 0.25 11.2 0.1 1.4 1 0 0 1 1 1 0 AbiJ N-terminal domain 5 FUSC-like PF12805.7 ELR18002.1 - 0.18 10.9 1.1 0.24 10.4 1.1 1.1 1 0 0 1 1 1 0 FUSC-like inner membrane protein yccS DUF3847 PF12958.7 ELR18002.1 - 0.24 11.5 4.3 0.38 10.9 4.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3847) IL4 PF00727.18 ELR18002.1 - 0.28 11.5 2.8 0.41 10.9 2.8 1.3 1 0 0 1 1 1 0 Interleukin 4 Csm1_N PF18504.1 ELR18002.1 - 0.39 11.1 4.9 1.1 9.6 4.9 1.7 1 1 0 1 1 1 0 Csm1 N-terminal domain LCD1 PF09798.9 ELR18002.1 - 2.1 6.7 5.2 2.8 6.3 5.2 1.0 1 0 0 1 1 1 0 DNA damage checkpoint protein SKA2 PF16740.5 ELR18002.1 - 4.8 7.0 8.0 6.7 6.5 0.9 2.1 1 1 1 2 2 2 0 Spindle and kinetochore-associated protein 2 TOBE_2 PF08402.10 ELR18003.1 - 0.081 13.1 0.1 8 6.7 0.0 3.0 2 0 0 2 2 2 0 TOBE domain AMP-binding PF00501.28 ELR18004.1 - 1.1e-57 195.5 0.0 1.1e-57 195.5 0.0 1.8 2 0 0 2 2 2 1 AMP-binding enzyme Ank_2 PF12796.7 ELR18004.1 - 4.6e-17 62.4 0.1 6.7e-06 26.6 0.0 4.3 3 2 0 3 3 3 3 Ankyrin repeats (3 copies) Ank_5 PF13857.6 ELR18004.1 - 2.2e-16 59.7 2.9 0.00015 22.0 0.0 6.4 6 1 1 7 7 7 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 ELR18004.1 - 2.6e-14 53.4 0.0 0.0031 18.1 0.0 5.1 4 0 0 4 4 4 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 ELR18004.1 - 7.1e-14 50.6 2.5 0.048 14.2 0.0 7.1 8 0 0 8 8 8 3 Ankyrin repeat Ank PF00023.30 ELR18004.1 - 2.3e-11 43.6 3.5 0.021 15.3 0.0 6.1 6 0 0 6 6 6 3 Ankyrin repeat F-box-like PF12937.7 ELR18004.1 - 0.00011 22.0 0.0 0.00027 20.8 0.0 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ELR18004.1 - 0.042 13.7 0.1 0.11 12.5 0.1 1.7 1 0 0 1 1 1 0 F-box domain TFIID_20kDa PF03847.13 ELR18005.1 - 1.1e-21 77.1 0.2 1.9e-21 76.3 0.2 1.4 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A TFIID-31kDa PF02291.15 ELR18005.1 - 0.0017 18.4 0.0 0.0026 17.8 0.0 1.3 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit CENP-T_C PF15511.6 ELR18005.1 - 0.0053 16.9 0.1 0.011 15.8 0.1 1.5 1 1 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold Band_7 PF01145.25 ELR18007.1 - 9.4e-18 64.8 4.3 1.1e-12 48.3 1.8 2.2 1 1 1 2 2 2 2 SPFH domain / Band 7 family DUF1269 PF06897.12 ELR18008.1 - 0.036 14.3 3.1 0.036 14.3 3.1 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1269) RhoGAP PF00620.27 ELR18009.1 - 6.4e-29 100.7 0.2 8.1e-29 100.4 0.2 1.1 1 0 0 1 1 1 1 RhoGAP domain Pkinase PF00069.25 ELR18010.1 - 5.1e-42 144.1 0.0 6.5e-42 143.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR18010.1 - 2.6e-26 92.4 0.0 3.5e-26 92.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase FTA2 PF13095.6 ELR18010.1 - 0.073 12.7 0.1 3.1 7.4 0.0 2.2 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 TraT PF05818.12 ELR18011.1 - 0.0028 17.4 0.1 0.006 16.3 0.1 1.5 1 0 0 1 1 1 1 Enterobacterial TraT complement resistance protein EphA2_TM PF14575.6 ELR18011.1 - 0.01 16.7 0.0 0.079 13.8 0.0 2.1 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain MAP17 PF15807.5 ELR18011.1 - 0.25 11.6 0.4 0.46 10.7 0.4 1.3 1 0 0 1 1 1 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 Myotub-related PF06602.14 ELR18012.1 - 8.2e-53 179.6 0.6 2.4e-36 125.4 1.0 3.5 3 1 0 3 3 3 2 Myotubularin-like phosphatase domain LRR_8 PF13855.6 ELR18012.1 - 2.2e-27 94.6 23.4 1.1e-07 31.5 0.8 6.0 5 1 1 6 6 6 5 Leucine rich repeat Roc PF08477.13 ELR18012.1 - 2.7e-18 66.3 1.4 7.6e-14 52.0 0.0 3.0 3 0 0 3 3 2 2 Ras of Complex, Roc, domain of DAPkinase LRR_4 PF12799.7 ELR18012.1 - 5.9e-17 61.5 24.5 0.00011 22.5 0.0 7.4 4 1 5 9 9 9 8 Leucine Rich repeats (2 copies) Ras PF00071.22 ELR18012.1 - 2.3e-14 53.3 0.2 1.6e-11 44.1 0.0 2.6 2 0 0 2 2 2 2 Ras family RasGAP PF00616.19 ELR18012.1 - 1.1e-13 51.3 0.0 1.4e-09 37.9 0.0 2.7 1 1 1 2 2 2 2 GTPase-activator protein for Ras-like GTPase COR PF16095.5 ELR18012.1 - 7.2e-07 29.2 0.0 1.3e-06 28.3 0.0 1.4 1 0 0 1 1 1 1 C-terminal of Roc, COR, domain LRR_1 PF00560.33 ELR18012.1 - 1.8e-05 24.6 6.8 16 6.5 0.0 8.6 9 0 0 9 9 8 0 Leucine Rich Repeat Arf PF00025.21 ELR18012.1 - 2.5e-05 23.8 0.1 0.032 13.7 0.0 3.8 4 0 0 4 4 4 1 ADP-ribosylation factor family Ribosomal_60s PF00428.19 ELR18012.1 - 6e-05 23.6 1.3 0.00072 20.1 0.3 3.3 2 0 0 2 2 2 1 60s Acidic ribosomal protein MMR_HSR1 PF01926.23 ELR18012.1 - 0.0002 21.4 0.8 0.0037 17.3 0.3 3.1 3 0 0 3 3 2 1 50S ribosome-binding GTPase LRR_9 PF14580.6 ELR18012.1 - 0.0006 19.4 12.3 0.31 10.5 1.0 3.5 2 1 1 3 3 3 2 Leucine-rich repeat LRR_6 PF13516.6 ELR18012.1 - 0.0012 18.7 10.4 9.1 6.6 0.0 6.3 5 0 0 5 5 5 1 Leucine Rich repeat GRAM PF02893.20 ELR18012.1 - 0.01 15.7 0.1 0.055 13.3 0.1 2.1 2 0 0 2 2 2 0 GRAM domain RsgA_GTPase PF03193.16 ELR18012.1 - 0.027 14.4 0.1 0.36 10.7 0.0 2.3 2 0 0 2 2 2 0 RsgA GTPase DUF2617 PF10936.8 ELR18012.1 - 0.042 13.9 0.3 0.099 12.7 0.3 1.5 1 0 0 1 1 1 0 Protein of unknown function DUF2617 DUF2610 PF11020.8 ELR18012.1 - 0.13 12.1 0.8 1 9.3 0.0 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF2610) BBL5 PF07289.11 ELR18012.1 - 0.18 10.9 0.0 0.34 9.9 0.0 1.4 1 0 0 1 1 1 0 Bardet-Biedl syndrome 5 protein LMBR1 PF04791.16 ELR18013.1 - 9.7e-47 160.0 25.4 7.1e-37 127.5 11.9 2.0 2 0 0 2 2 2 2 LMBR1-like membrane protein Sad1_UNC PF07738.13 ELR18014.1 - 2.9e-33 114.7 0.0 7.4e-33 113.4 0.0 1.7 2 0 0 2 2 2 1 Sad1 / UNC-like C-terminal HTH_1 PF00126.27 ELR18014.1 - 0.0059 16.5 1.5 0.81 9.7 0.3 3.2 3 0 0 3 3 3 1 Bacterial regulatory helix-turn-helix protein, lysR family DUF4131 PF13567.6 ELR18014.1 - 0.017 14.8 0.3 0.035 13.8 0.3 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) DUF4400 PF14348.6 ELR18014.1 - 0.065 12.7 0.3 4.2 6.8 0.0 3.3 3 1 0 3 3 3 0 Domain of unknown function (DUF4400) DUF3138 PF11336.8 ELR18014.1 - 0.19 10.3 9.8 0.17 10.4 2.7 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3138) Baculo_PEP_C PF04513.12 ELR18014.1 - 0.2 11.7 8.0 5.3 7.1 1.6 2.9 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Tweety PF04906.13 ELR18014.1 - 0.31 9.6 4.7 1.8 7.2 0.7 2.5 1 1 1 2 2 2 0 Tweety DUF1664 PF07889.12 ELR18014.1 - 1.7 8.7 13.4 0.97 9.5 0.5 3.4 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) Syntaxin-6_N PF09177.11 ELR18014.1 - 3.4 8.3 17.9 1 10.0 5.1 3.3 3 2 0 3 3 3 0 Syntaxin 6, N-terminal DASH_Dad3 PF08656.10 ELR18014.1 - 5 7.3 9.6 27 4.9 0.8 3.4 1 1 1 2 2 2 0 DASH complex subunit Dad3 Exonuc_VII_L PF02601.15 ELR18014.1 - 5.8 6.4 17.9 0.51 9.9 6.2 2.2 1 1 1 2 2 2 0 Exonuclease VII, large subunit ING PF12998.7 ELR18014.1 - 6.4 7.4 9.5 1.6 9.3 0.6 3.2 2 1 1 3 3 3 0 Inhibitor of growth proteins N-terminal histone-binding KxDL PF10241.9 ELR18014.1 - 7.7 6.9 9.0 7.6 6.9 1.1 3.1 2 2 1 3 3 3 0 Uncharacterized conserved protein Lectin_N PF03954.14 ELR18014.1 - 8.1 6.2 8.3 20 4.9 0.4 3.2 2 1 1 3 3 3 0 Hepatic lectin, N-terminal domain DUF4239 PF14023.6 ELR18014.1 - 9.8 5.8 13.5 5 6.8 2.8 3.0 2 1 1 4 4 4 0 Protein of unknown function (DUF4239) Kinocilin PF15033.6 ELR18015.1 - 1.2 8.7 3.5 0.71 9.5 1.3 1.6 1 1 1 2 2 2 0 Kinocilin protein Phage_1_1 PF08200.11 ELR18015.1 - 5.6 7.5 7.3 0.2 12.1 1.1 1.9 2 0 0 2 2 2 0 Bacteriophage 1.1 Protein DNA_topoisoIV PF00521.20 ELR18016.1 - 1.3e-91 307.6 0.0 2.1e-91 306.9 0.0 1.3 1 0 0 1 1 1 1 DNA gyrase/topoisomerase IV, subunit A TOPRIM_C PF16898.5 ELR18016.1 - 1.2e-42 145.2 5.9 2.8e-42 144.0 5.9 1.7 1 0 0 1 1 1 1 C-terminal associated domain of TOPRIM DNA_gyraseB PF00204.25 ELR18016.1 - 5.9e-23 81.2 0.0 1.1e-22 80.4 0.0 1.4 1 0 0 1 1 1 1 DNA gyrase B HATPase_c PF02518.26 ELR18016.1 - 5.7e-11 42.9 0.0 1.2e-10 41.9 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Toprim PF01751.22 ELR18016.1 - 3.4e-07 30.4 0.0 7.7e-07 29.3 0.0 1.6 1 0 0 1 1 1 1 Toprim domain RIB43A PF05914.12 ELR18016.1 - 0.19 10.5 1.8 0.33 9.7 1.8 1.3 1 0 0 1 1 1 0 RIB43A DNA_topoisoIV PF00521.20 ELR18017.1 - 5.4e-11 42.0 1.2 6e-11 41.9 1.2 1.0 1 0 0 1 1 1 1 DNA gyrase/topoisomerase IV, subunit A RCC1_2 PF13540.6 ELR18018.1 - 7.1e-35 118.1 57.8 3.2e-09 36.3 2.5 8.9 9 0 0 9 9 9 7 Regulator of chromosome condensation (RCC1) repeat SKG6 PF08693.10 ELR18018.1 - 8.1e-05 21.9 5.5 0.00031 20.1 5.5 2.1 1 0 0 1 1 1 1 Transmembrane alpha-helix domain RCC1 PF00415.18 ELR18018.1 - 0.0079 16.8 0.1 0.0079 16.8 0.1 8.6 7 2 1 8 8 8 2 Regulator of chromosome condensation (RCC1) repeat SKG6 PF08693.10 ELR18019.1 - 7.7 6.0 13.2 21 4.6 13.2 1.8 1 1 0 1 1 1 0 Transmembrane alpha-helix domain UDPGT PF00201.18 ELR18020.1 - 9.8e-11 41.1 0.0 1.3e-10 40.7 0.0 1.1 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.16 ELR18020.1 - 1.4e-08 34.9 0.0 1.7e-08 34.6 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain Glyco_trans_1_3 PF13528.6 ELR18020.1 - 0.11 11.7 0.0 0.14 11.4 0.0 1.1 1 0 0 1 1 1 0 Glycosyl transferase family 1 YL1 PF05764.13 ELR18023.1 - 0.0015 18.7 17.1 0.0018 18.4 17.1 1.1 1 0 0 1 1 1 1 YL1 nuclear protein Conotoxin PF02950.17 ELR18023.1 - 0.033 15.2 1.6 0.033 15.2 1.6 3.0 2 1 1 3 3 3 0 Conotoxin CD20 PF04103.15 ELR18023.1 - 0.034 14.2 2.5 0.43 10.6 2.5 2.5 1 1 0 1 1 1 0 CD20-like family GCOM2 PF15328.6 ELR18023.1 - 2.3 8.6 19.7 2.8 8.3 19.7 1.2 1 0 0 1 1 1 0 Putative GRINL1B complex locus protein 2 Tetraspanin PF00335.20 ELR18023.1 - 4.1 7.0 6.0 5.8 6.5 6.0 1.3 1 0 0 1 1 1 0 Tetraspanin family DUF908 PF06012.12 ELR18023.1 - 4.6 6.6 14.3 5.1 6.4 14.3 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF908) Ank_2 PF12796.7 ELR18024.1 - 9.7e-21 74.2 0.0 9.7e-07 29.3 0.0 4.5 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank_3 PF13606.6 ELR18024.1 - 6.7e-14 50.7 1.1 0.0051 17.2 0.0 8.1 8 0 0 8 8 8 3 Ankyrin repeat Ank_4 PF13637.6 ELR18024.1 - 7e-14 52.0 1.8 1.7e-05 25.2 0.0 6.1 4 1 3 7 7 7 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 ELR18024.1 - 5.7e-13 48.8 5.6 1.8e-08 34.5 0.1 5.3 5 1 0 5 5 5 2 Ankyrin repeats (many copies) Ank PF00023.30 ELR18024.1 - 5.7e-08 32.9 11.5 0.28 11.7 0.0 7.4 7 2 1 8 8 8 3 Ankyrin repeat F-box-like PF12937.7 ELR18024.1 - 0.0062 16.4 0.6 0.014 15.3 0.6 1.7 1 0 0 1 1 1 1 F-box-like DUF4129 PF13559.6 ELR18024.1 - 0.049 13.9 0.5 0.27 11.5 0.2 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4129) ADH_zinc_N PF00107.26 ELR18025.1 - 6.7e-19 68.1 0.0 1.1e-18 67.4 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N_2 PF16884.5 ELR18025.1 - 1.8e-16 59.9 0.0 8.2e-16 57.9 0.0 2.1 2 1 0 2 2 2 1 N-terminal domain of oxidoreductase ADH_zinc_N_2 PF13602.6 ELR18025.1 - 7e-08 33.6 0.0 1.3e-07 32.7 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase PGM_PMM_II PF02879.16 ELR18025.1 - 0.13 12.9 0.0 1.9 9.1 0.1 2.2 2 0 0 2 2 2 0 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II Aldedh PF00171.22 ELR18026.1 - 8.6e-42 143.2 0.0 9.7e-42 143.0 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family SKG6 PF08693.10 ELR18027.1 - 1.2e-05 24.6 1.5 2.1e-05 23.9 1.5 1.4 1 0 0 1 1 1 1 Transmembrane alpha-helix domain SKG6 PF08693.10 ELR18029.1 - 1e-06 28.0 4.3 2.4e-06 26.8 4.3 1.7 1 0 0 1 1 1 1 Transmembrane alpha-helix domain Myc_target_1 PF15179.6 ELR18029.1 - 0.0073 16.2 0.2 0.013 15.4 0.2 1.4 1 0 0 1 1 1 1 Myc target protein 1 EII-Sor PF03609.14 ELR18029.1 - 0.097 12.1 2.3 0.12 11.8 1.0 1.7 2 0 0 2 2 2 0 PTS system sorbose-specific iic component TNFR_16_TM PF18422.1 ELR18029.1 - 0.52 10.3 2.8 2 8.5 2.8 2.0 1 1 0 1 1 1 0 Tumor necrosis factor receptor member 16 trans-membrane domain Kelch_6 PF13964.6 ELR18030.1 - 5.4e-09 36.0 21.5 0.089 13.1 0.0 7.8 8 0 0 8 8 8 4 Kelch motif Kelch_4 PF13418.6 ELR18030.1 - 4e-07 29.9 40.1 0.00011 22.1 0.1 8.3 6 3 2 8 8 8 5 Galactose oxidase, central domain Kelch_2 PF07646.15 ELR18030.1 - 4e-06 26.6 10.7 0.0052 16.7 0.1 5.2 6 0 0 6 6 6 3 Kelch motif Kelch_1 PF01344.25 ELR18030.1 - 1.6e-05 24.4 28.5 0.017 14.7 0.4 6.6 8 0 0 8 8 8 4 Kelch motif Kelch_5 PF13854.6 ELR18030.1 - 0.00025 21.0 6.4 6.5 6.9 0.0 6.4 7 0 0 7 7 7 1 Kelch motif RhoGEF PF00621.20 ELR18032.1 - 4e-44 151.0 1.7 5.8e-44 150.5 0.1 2.0 2 0 0 2 2 2 1 RhoGEF domain PX PF00787.24 ELR18032.1 - 1.4e-19 70.2 2.1 4e-19 68.7 1.2 2.2 2 0 0 2 2 2 1 PX domain Pepsin-I3 PF06394.13 ELR18032.1 - 0.11 12.7 0.1 0.11 12.7 0.1 2.4 2 0 0 2 2 2 0 Pepsin inhibitor-3-like repeated domain DUF4603 PF15376.6 ELR18033.1 - 3.1 5.1 3.8 3.7 4.8 3.8 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4603) GTP_EFTU PF00009.27 ELR18035.1 - 6.6e-37 126.9 0.0 8.1e-37 126.6 0.0 1.1 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain F-box-like PF12937.7 ELR18035.1 - 1.2e-09 38.0 0.4 1.2e-09 38.0 0.4 1.9 2 0 0 2 2 2 1 F-box-like MMR_HSR1 PF01926.23 ELR18035.1 - 7.4e-08 32.5 0.0 8.8e-05 22.6 0.0 2.4 2 0 0 2 2 2 2 50S ribosome-binding GTPase F-box PF00646.33 ELR18035.1 - 0.0046 16.8 0.0 0.01 15.7 0.0 1.5 1 0 0 1 1 1 1 F-box domain Gtr1_RagA PF04670.12 ELR18035.1 - 0.02 14.2 0.0 0.046 13.1 0.0 1.5 1 1 0 1 1 1 0 Gtr1/RagA G protein conserved region SRPRB PF09439.10 ELR18035.1 - 0.057 12.9 0.0 6.1 6.2 0.0 2.2 2 0 0 2 2 2 0 Signal recognition particle receptor beta subunit FeoB_N PF02421.18 ELR18035.1 - 0.058 12.9 0.1 1.5 8.3 0.0 2.8 2 1 0 2 2 2 0 Ferrous iron transport protein B Roc PF08477.13 ELR18035.1 - 0.18 12.0 0.7 7.3 6.8 0.1 2.6 1 1 1 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase Ank_4 PF13637.6 ELR18036.1 - 4.4e-11 43.1 0.0 2.7e-10 40.6 0.0 1.9 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 ELR18036.1 - 2.4e-10 40.8 0.0 3.9e-10 40.2 0.0 1.3 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 ELR18036.1 - 2.9e-09 37.0 0.1 7.1e-08 32.6 0.0 2.0 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 ELR18036.1 - 3.8e-08 33.0 0.0 4.2e-05 23.6 0.0 3.1 3 0 0 3 3 3 1 Ankyrin repeat Ank PF00023.30 ELR18036.1 - 1.9e-07 31.2 0.0 1.7e-05 25.0 0.0 2.9 3 0 0 3 3 3 1 Ankyrin repeat Ank_4 PF13637.6 ELR18038.1 - 4.4e-11 43.1 0.0 2.7e-10 40.6 0.0 1.9 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 ELR18038.1 - 2.9e-10 40.6 0.0 4.5e-10 40.0 0.0 1.3 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 ELR18038.1 - 2.6e-09 37.1 0.1 7.1e-08 32.6 0.0 2.0 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 ELR18038.1 - 4.4e-08 32.8 0.0 4.2e-05 23.6 0.0 3.1 3 0 0 3 3 3 1 Ankyrin repeat Ank PF00023.30 ELR18038.1 - 2.1e-07 31.0 0.0 1.7e-05 25.0 0.0 2.8 3 0 0 3 3 3 1 Ankyrin repeat DUF3754 PF12576.8 ELR18039.1 - 1.2e-21 77.1 0.1 2e-21 76.4 0.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3754) XRN_N PF03159.18 ELR18040.1 - 3.8e-51 173.9 0.0 5.8e-51 173.3 0.0 1.3 1 0 0 1 1 1 1 XRN 5'-3' exonuclease N-terminus XRN_M PF17846.1 ELR18040.1 - 4e-07 29.4 0.0 0.00049 19.2 0.0 2.4 2 0 0 2 2 2 2 Xrn1 helical domain TetR_C_31 PF17940.1 ELR18040.1 - 0.75 10.0 8.9 3.6 7.8 2.5 2.7 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain Nop14 PF04147.12 ELR18040.1 - 0.95 7.6 13.0 1.4 7.0 13.0 1.1 1 0 0 1 1 1 0 Nop14-like family RCC1 PF00415.18 ELR18041.1 - 9.6e-23 80.6 4.5 6.5e-07 29.9 0.1 6.7 7 0 0 7 7 7 4 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 ELR18041.1 - 3.4e-19 68.1 9.7 5.7e-06 26.0 0.6 5.0 5 0 0 5 5 5 3 Regulator of chromosome condensation (RCC1) repeat F-box-like PF12937.7 ELR18041.1 - 7.2e-07 29.0 0.1 1.4e-06 28.1 0.1 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ELR18041.1 - 0.0011 18.7 0.1 0.0022 17.8 0.1 1.4 1 0 0 1 1 1 1 F-box domain F-box_5 PF18511.1 ELR18041.1 - 0.059 12.9 0.1 0.12 11.9 0.1 1.5 1 0 0 1 1 1 0 F-box SAM_MT PF04445.13 ELR18041.1 - 0.061 12.7 0.0 0.13 11.7 0.0 1.4 1 0 0 1 1 1 0 Putative SAM-dependent methyltransferase SUKH-3 PF14433.6 ELR18041.1 - 0.15 12.5 0.0 4.5 7.7 0.0 2.4 2 0 0 2 2 2 0 SUKH-3 immunity protein DUF3658 PF12395.8 ELR18041.1 - 0.2 11.6 0.0 0.34 10.8 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function PQQ_3 PF13570.6 ELR18041.1 - 4.2 8.0 8.9 35 5.1 0.0 4.0 5 0 0 5 5 5 0 PQQ-like domain Fer4_20 PF14691.6 ELR18042.1 - 0.013 15.3 4.9 1.1 9.0 0.2 2.5 2 0 0 2 2 2 0 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster 1-cysPrx_C PF10417.9 ELR18042.1 - 0.024 14.5 0.5 13 5.7 0.1 3.0 3 0 0 3 3 3 0 C-terminal domain of 1-Cys peroxiredoxin BRCT PF00533.26 ELR18045.1 - 0.0013 19.1 0.1 0.0032 17.8 0.1 1.7 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 ELR18045.1 - 0.0054 17.1 0.1 0.016 15.6 0.1 1.8 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain Herpes_UL32 PF06070.11 ELR18045.1 - 0.0067 14.3 4.2 0.0093 13.8 4.2 1.2 1 0 0 1 1 1 1 Herpesvirus large structural phosphoprotein UL32 Helicase_PWI PF18149.1 ELR18045.1 - 0.039 14.1 0.9 0.11 12.7 0.9 1.7 1 0 0 1 1 1 0 N-terminal helicase PWI domain DUF572 PF04502.13 ELR18045.1 - 0.15 11.6 21.5 0.2 11.2 21.5 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) SRP-alpha_N PF04086.13 ELR18045.1 - 0.28 11.0 21.1 0.41 10.5 21.1 1.3 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal Atg14 PF10186.9 ELR18045.1 - 9.7 5.2 12.1 15 4.6 12.1 1.3 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 TIG PF01833.24 ELR18046.1 - 0.0032 17.5 0.0 0.8 9.8 0.0 2.2 2 0 0 2 2 2 2 IPT/TIG domain SPT2 PF08243.11 ELR18047.1 - 5.2e-17 62.4 27.7 8.3e-17 61.7 27.7 1.2 1 0 0 1 1 1 1 SPT2 chromatin protein BUD22 PF09073.10 ELR18047.1 - 0.35 10.2 17.2 0.43 9.9 17.2 1.1 1 0 0 1 1 1 0 BUD22 Pkinase PF00069.25 ELR18048.1 - 1.3e-57 195.2 0.0 2.4e-57 194.3 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR18048.1 - 1.2e-42 146.0 0.0 1.8e-42 145.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 ELR18048.1 - 3.7e-09 35.9 2.1 7.1e-08 31.6 0.0 2.2 2 0 0 2 2 2 1 Fungal protein kinase Haspin_kinase PF12330.8 ELR18048.1 - 0.0019 17.2 0.0 0.0036 16.3 0.0 1.4 1 0 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 ELR18048.1 - 0.0062 15.9 0.0 0.013 14.9 0.0 1.4 1 0 0 1 1 1 1 Kinase-like CDC45 PF02724.14 ELR18048.1 - 0.28 9.4 11.7 0.55 8.4 11.7 1.4 1 0 0 1 1 1 0 CDC45-like protein RR_TM4-6 PF06459.12 ELR18048.1 - 0.97 9.2 8.1 1.8 8.3 8.1 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 FAM76 PF16046.5 ELR18048.1 - 1.2 8.4 10.9 2 7.7 10.9 1.2 1 0 0 1 1 1 0 FAM76 protein XAP5 PF04921.14 ELR18048.1 - 2.4 7.9 10.6 4.3 7.1 10.6 1.4 1 0 0 1 1 1 0 XAP5, circadian clock regulator Coilin_N PF15862.5 ELR18048.1 - 3 7.6 13.9 6 6.7 13.9 1.5 1 0 0 1 1 1 0 Coilin N-terminus Apt1 PF10351.9 ELR18048.1 - 3.9 6.2 9.4 6.6 5.5 9.4 1.3 1 0 0 1 1 1 0 Golgi-body localisation protein domain LIM PF00412.22 ELR18049.1 - 5.8e-25 87.3 14.0 2.1e-12 47.0 3.4 2.3 2 0 0 2 2 2 2 LIM domain Jnk-SapK_ap_N PF09744.9 ELR18049.1 - 0.061 13.5 9.1 0.14 12.3 9.1 1.6 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 GAS PF13851.6 ELR18049.1 - 0.078 12.3 7.4 0.13 11.6 7.4 1.3 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding PKcGMP_CC PF16808.5 ELR18049.1 - 0.095 12.6 6.3 0.21 11.5 6.3 1.5 1 0 0 1 1 1 0 Coiled-coil N-terminus of cGMP-dependent protein kinase TMPIT PF07851.13 ELR18049.1 - 0.18 11.0 5.3 0.26 10.5 5.3 1.1 1 0 0 1 1 1 0 TMPIT-like protein Mod_r PF07200.13 ELR18049.1 - 0.19 11.8 10.1 0.11 12.6 5.8 2.1 2 0 0 2 2 2 0 Modifier of rudimentary (Mod(r)) protein DUF4201 PF13870.6 ELR18049.1 - 0.21 11.3 8.3 0.43 10.3 8.3 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4201) YabA PF06156.13 ELR18049.1 - 0.29 11.8 2.6 0.71 10.5 2.6 1.7 1 0 0 1 1 1 0 Initiation control protein YabA Spc7 PF08317.11 ELR18049.1 - 0.51 9.2 7.5 0.78 8.6 7.5 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF4407 PF14362.6 ELR18049.1 - 0.84 8.9 11.3 1.3 8.3 11.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Herpes_BLRF2 PF05812.12 ELR18049.1 - 1.1 9.4 7.0 21 5.3 7.5 2.6 1 1 1 2 2 2 0 Herpesvirus BLRF2 protein ZapB PF06005.12 ELR18049.1 - 4.1 7.9 14.6 63 4.1 14.7 2.3 1 1 0 1 1 1 0 Cell division protein ZapB SlyX PF04102.12 ELR18049.1 - 6.5 7.4 12.9 0.24 12.0 5.9 2.3 2 1 1 3 3 2 0 SlyX HEAT_2 PF13646.6 ELR18050.1 - 2.3e-05 24.7 6.1 8.3e-05 22.9 0.0 3.2 2 2 0 2 2 2 1 HEAT repeats Cnd1 PF12717.7 ELR18050.1 - 4.2e-05 23.6 0.6 0.00086 19.4 0.1 2.5 3 0 0 3 3 3 1 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.22 ELR18050.1 - 0.00015 21.7 1.2 0.16 12.3 0.0 4.4 4 1 1 5 5 5 1 HEAT repeat HEAT_EZ PF13513.6 ELR18050.1 - 0.15 12.6 5.9 35 5.0 0.0 4.7 3 2 2 5 5 5 0 HEAT-like repeat FKBP_C PF00254.28 ELR18052.1 - 3e-19 69.1 0.0 6.3e-18 64.9 0.0 2.3 1 1 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase TPR_2 PF07719.17 ELR18052.1 - 7.7e-10 38.1 6.8 2.7e-05 23.9 0.8 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 ELR18052.1 - 4.2e-09 35.8 6.4 4e-05 23.2 0.1 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.6 ELR18052.1 - 2.2e-07 31.2 11.5 1.2e-05 25.7 3.0 2.5 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_11 PF13414.6 ELR18052.1 - 4.4e-07 29.5 4.0 0.0016 18.1 0.0 3.4 2 1 1 3 3 3 2 TPR repeat TPR_6 PF13174.6 ELR18052.1 - 4.7e-06 26.9 1.7 0.012 16.2 0.1 3.2 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_7 PF13176.6 ELR18052.1 - 1e-05 25.2 4.6 0.0025 17.7 0.1 3.7 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_8 PF13181.6 ELR18052.1 - 2.1e-05 24.4 4.2 0.0016 18.5 0.2 3.1 3 0 0 3 3 2 1 Tetratricopeptide repeat TPR_16 PF13432.6 ELR18052.1 - 3.1e-05 24.5 2.6 3.1e-05 24.5 2.6 2.9 1 1 3 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.6 ELR18052.1 - 9.5e-05 22.9 7.2 0.0012 19.4 0.1 3.5 2 1 2 4 4 3 2 Tetratricopeptide repeat TPR_12 PF13424.6 ELR18052.1 - 0.00016 21.9 8.1 0.00062 20.0 2.5 3.2 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_17 PF13431.6 ELR18052.1 - 0.00074 19.7 5.7 0.0056 17.0 0.0 3.5 4 0 0 4 4 3 1 Tetratricopeptide repeat TPR_9 PF13371.6 ELR18052.1 - 0.0012 18.9 3.3 0.0027 17.8 3.3 1.6 1 0 0 1 1 1 1 Tetratricopeptide repeat ANAPC3 PF12895.7 ELR18052.1 - 0.0095 16.1 4.2 0.033 14.4 4.2 1.9 1 1 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 Fis1_TPR_C PF14853.6 ELR18052.1 - 0.012 15.7 1.2 0.082 13.0 0.2 2.4 1 1 1 2 2 2 0 Fis1 C-terminal tetratricopeptide repeat DUF3808 PF10300.9 ELR18052.1 - 0.02 13.6 0.5 0.026 13.3 0.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3808) TPR_21 PF09976.9 ELR18052.1 - 0.041 13.6 8.7 0.076 12.7 8.7 1.5 1 1 0 1 1 1 0 Tetratricopeptide repeat-like domain TPR_10 PF13374.6 ELR18052.1 - 0.9 9.5 4.0 4.5 7.3 0.4 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat Gelsolin PF00626.22 ELR18053.1 - 4.2e-16 58.6 0.0 6.4e-16 58.0 0.0 1.3 1 0 0 1 1 1 1 Gelsolin repeat MbeB_N PF04837.12 ELR18053.1 - 0.047 14.0 0.1 0.086 13.2 0.1 1.3 1 0 0 1 1 1 0 MbeB-like, N-term conserved region Ribosomal_L11_N PF03946.14 ELR18053.1 - 0.16 11.8 0.0 0.28 11.1 0.0 1.4 1 0 0 1 1 1 0 Ribosomal protein L11, N-terminal domain Sulfate_transp PF00916.20 ELR18054.1 - 7.7e-33 113.8 6.0 1.1e-32 113.3 6.0 1.3 1 0 0 1 1 1 1 Sulfate permease family STAS PF01740.21 ELR18054.1 - 4.9e-13 48.7 0.0 7.7e-13 48.1 0.0 1.3 1 0 0 1 1 1 1 STAS domain MrpF_PhaF PF04066.13 ELR18054.1 - 0.00079 19.8 0.1 0.00079 19.8 0.1 2.4 2 1 0 2 2 2 1 Multiple resistance and pH regulation protein F (MrpF / PhaF) Pribosyltran PF00156.27 ELR18055.1 - 0.00027 20.5 0.0 0.00043 19.8 0.0 1.4 1 0 0 1 1 1 1 Phosphoribosyl transferase domain SPRY PF00622.28 ELR18056.1 - 0.00065 19.8 0.0 0.00077 19.6 0.0 1.1 1 0 0 1 1 1 1 SPRY domain Pkinase PF00069.25 ELR18057.1 - 9.6e-13 48.1 0.0 7.5e-06 25.5 0.0 2.3 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ELR18057.1 - 0.00054 19.3 0.0 0.96 8.7 0.0 2.4 2 0 0 2 2 2 2 Protein tyrosine kinase ZapB PF06005.12 ELR18057.1 - 0.011 16.1 3.7 0.011 16.1 3.7 3.8 4 0 0 4 4 4 0 Cell division protein ZapB Ank_2 PF12796.7 ELR18057.1 - 0.045 14.4 0.0 0.12 12.9 0.0 1.7 1 0 0 1 1 1 0 Ankyrin repeats (3 copies) PID_2 PF14719.6 ELR18057.1 - 0.11 12.4 0.6 1.6 8.6 0.0 2.5 2 0 0 2 2 2 0 Phosphotyrosine interaction domain (PTB/PID) DUF769 PF05590.11 ELR18057.1 - 0.27 10.6 1.5 0.52 9.7 1.5 1.4 1 0 0 1 1 1 0 Xylella fastidiosa protein of unknown function (DUF769) Ank_2 PF12796.7 ELR18058.1 - 1.7e-46 156.7 3.4 1.9e-17 63.6 0.1 4.7 2 1 1 4 4 4 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ELR18058.1 - 7.4e-45 150.8 6.9 2.9e-10 40.5 0.1 7.8 4 2 4 8 8 8 8 Ankyrin repeats (many copies) Ank_3 PF13606.6 ELR18058.1 - 6.9e-39 127.4 7.4 8.8e-05 22.6 0.0 9.5 9 0 0 9 9 9 8 Ankyrin repeat Ank_5 PF13857.6 ELR18058.1 - 4.6e-38 128.8 18.0 5.9e-07 29.6 0.0 8.2 2 1 6 8 8 8 7 Ankyrin repeats (many copies) Ank PF00023.30 ELR18058.1 - 2.9e-36 122.3 21.5 6.1e-08 32.8 0.0 9.3 9 0 0 9 9 9 8 Ankyrin repeat FYVE PF01363.21 ELR18058.1 - 6.8e-08 32.5 4.8 1.5e-07 31.5 4.8 1.5 1 0 0 1 1 1 1 FYVE zinc finger Arm-DNA-bind_3 PF13356.6 ELR18058.1 - 0.011 16.1 0.1 1.2 9.5 0.1 2.5 2 0 0 2 2 2 0 Arm DNA-binding domain Rotamase PF00639.21 ELR18059.1 - 1.3e-18 67.8 0.0 1.3e-18 67.7 0.0 1.0 1 0 0 1 1 1 1 PPIC-type PPIASE domain Rotamase_3 PF13616.6 ELR18059.1 - 6.4e-14 52.5 0.0 6.9e-14 52.4 0.0 1.0 1 0 0 1 1 1 1 PPIC-type PPIASE domain Rotamase_2 PF13145.6 ELR18059.1 - 0.005 17.7 0.0 0.005 17.7 0.0 1.1 1 0 0 1 1 1 1 PPIC-type PPIASE domain Forkhead PF00250.18 ELR18060.1 - 3.4e-05 24.0 0.0 6e-05 23.2 0.0 1.4 1 0 0 1 1 1 1 Forkhead domain SAP PF02037.27 ELR18060.1 - 0.00011 21.8 0.0 0.00023 20.8 0.0 1.6 1 0 0 1 1 1 1 SAP domain SR-25 PF10500.9 ELR18061.1 - 9.4 5.8 33.1 0.72 9.4 2.2 2.8 2 1 1 3 3 3 0 Nuclear RNA-splicing-associated protein Pkinase PF00069.25 ELR18062.1 - 4e-21 75.6 0.0 5.6e-12 45.6 0.0 2.1 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ELR18062.1 - 1.4e-20 73.7 0.1 2.8e-11 43.2 0.2 2.1 1 1 1 2 2 2 2 Protein tyrosine kinase RskA PF10099.9 ELR18062.1 - 0.044 14.1 0.2 0.061 13.6 0.2 1.3 1 0 0 1 1 1 0 Anti-sigma-K factor rskA G-alpha PF00503.20 ELR18063.1 - 0.00042 19.6 0.0 0.00042 19.6 0.0 1.1 1 0 0 1 1 1 1 G-protein alpha subunit Peptidase_C5 PF00770.18 ELR18064.1 - 0.14 11.8 0.0 1.1 8.9 0.1 2.0 2 0 0 2 2 2 0 Adenovirus endoprotease DUF3421 PF11901.8 ELR18065.1 - 5e-40 136.1 11.1 6.1e-24 84.2 3.6 2.9 1 1 2 3 3 3 3 Protein of unknown function (DUF3421) Frizzled PF01534.17 ELR18066.1 - 2.6e-23 82.6 18.6 3.6e-23 82.1 18.6 1.1 1 0 0 1 1 1 1 Frizzled/Smoothened family membrane region Dicty_CAR PF05462.11 ELR18066.1 - 2e-07 30.4 4.2 3.6e-07 29.6 4.2 1.3 1 0 0 1 1 1 1 Slime mold cyclic AMP receptor HEAT PF02985.22 ELR18068.1 - 0.043 14.1 0.9 52 4.5 0.1 4.7 4 0 0 4 4 4 0 HEAT repeat RCC1 PF00415.18 ELR18070.1 - 8e-32 109.6 2.7 2.5e-14 53.6 0.1 5.5 6 0 0 6 6 6 4 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 ELR18070.1 - 4.1e-23 80.6 8.5 5.4e-08 32.4 0.4 5.6 5 0 0 5 5 5 4 Regulator of chromosome condensation (RCC1) repeat F-box-like PF12937.7 ELR18070.1 - 0.061 13.2 0.0 0.12 12.3 0.0 1.4 1 0 0 1 1 1 0 F-box-like PLAC8 PF04749.17 ELR18071.1 - 3.2 8.8 10.8 0.56 11.2 5.4 2.0 1 1 1 2 2 2 0 PLAC8 family EF-hand_6 PF13405.6 ELR18072.1 - 1.4e-10 40.2 0.7 3.3e-05 23.5 0.1 3.7 3 1 0 3 3 3 2 EF-hand domain EF-hand_7 PF13499.6 ELR18072.1 - 2.7e-10 40.5 1.1 0.0005 20.5 0.1 2.8 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 ELR18072.1 - 5.7e-10 38.0 0.9 1.7e-05 24.0 0.0 3.5 5 0 0 5 5 5 2 EF hand EF-hand_5 PF13202.6 ELR18072.1 - 2.8e-06 26.5 0.7 1.6e-05 24.2 0.1 2.4 3 0 0 3 3 3 1 EF hand EF-hand_8 PF13833.6 ELR18072.1 - 4.1e-05 23.3 1.3 0.025 14.4 0.0 3.2 3 1 0 3 3 3 2 EF-hand domain pair EF-hand_9 PF14658.6 ELR18072.1 - 8.9e-05 22.7 0.1 0.48 10.8 0.0 2.8 3 0 0 3 3 3 2 EF-hand domain EF-hand_4 PF12763.7 ELR18072.1 - 0.00028 20.8 1.0 0.0013 18.6 0.3 2.1 2 1 0 2 2 2 1 Cytoskeletal-regulatory complex EF hand BUD22 PF09073.10 ELR18072.1 - 0.0027 17.1 5.4 0.0031 16.9 5.4 1.1 1 0 0 1 1 1 1 BUD22 Peptidase_S76 PF13611.6 ELR18072.1 - 0.0048 17.2 1.2 0.0096 16.2 1.2 1.6 1 1 0 1 1 1 1 Serine peptidase of plant viral polyprotein, P1 AbiEi_1 PF09407.10 ELR18072.1 - 0.029 14.7 0.3 1.1 9.6 0.0 2.1 2 0 0 2 2 2 0 AbiEi antitoxin C-terminal domain EF-hand_14 PF17959.1 ELR18072.1 - 0.061 13.7 1.4 0.38 11.1 0.5 2.4 2 2 0 2 2 2 0 EF-hand domain Fes1 PF08609.10 ELR18072.1 - 0.22 12.4 5.1 0.43 11.5 4.7 2.0 1 1 0 1 1 1 0 Nucleotide exchange factor Fes1 Ribosomal_60s PF00428.19 ELR18072.1 - 2.7 8.6 15.3 70 4.1 15.2 2.7 1 1 0 1 1 1 0 60s Acidic ribosomal protein Ank_2 PF12796.7 ELR18073.1 - 1.7e-21 76.6 0.0 1.4e-09 38.4 0.0 2.1 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 ELR18073.1 - 1.4e-18 66.7 0.4 5.1e-07 29.8 0.0 3.2 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.30 ELR18073.1 - 3.7e-18 65.1 0.1 0.00015 22.1 0.0 4.1 4 0 0 4 4 4 4 Ankyrin repeat Ank_4 PF13637.6 ELR18073.1 - 1.3e-16 60.7 0.0 1e-06 29.1 0.0 2.9 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 ELR18073.1 - 6.2e-16 56.9 0.0 0.00062 20.0 0.0 4.1 4 0 0 4 4 4 3 Ankyrin repeat Dus PF01207.17 ELR18074.1 - 3.4e-35 121.6 0.0 3.9e-35 121.4 0.0 1.1 1 0 0 1 1 1 1 Dihydrouridine synthase (Dus) His_biosynth PF00977.21 ELR18074.1 - 2.8e-06 27.0 0.0 8.7e-06 25.4 0.0 1.7 2 0 0 2 2 2 1 Histidine biosynthesis protein ThiG PF05690.14 ELR18074.1 - 0.00027 20.4 0.0 0.00036 19.9 0.0 1.2 1 0 0 1 1 1 1 Thiazole biosynthesis protein ThiG TMP-TENI PF02581.17 ELR18074.1 - 0.0015 17.9 0.0 0.0025 17.1 0.0 1.4 1 0 0 1 1 1 1 Thiamine monophosphate synthase NMO PF03060.15 ELR18074.1 - 0.013 14.9 0.0 0.018 14.5 0.0 1.2 1 0 0 1 1 1 0 Nitronate monooxygenase G3P_antiterm PF04309.12 ELR18074.1 - 0.019 14.4 0.0 0.028 13.8 0.0 1.3 1 0 0 1 1 1 0 Glycerol-3-phosphate responsive antiterminator HMGL-like PF00682.19 ELR18074.1 - 0.11 12.0 0.0 0.19 11.2 0.0 1.3 1 0 0 1 1 1 0 HMGL-like EIF_2_alpha PF07541.12 ELR18076.1 - 1.3e-35 122.0 0.0 2.7e-35 121.0 0.0 1.6 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 2 alpha subunit S1 PF00575.23 ELR18076.1 - 4.9e-14 52.4 0.5 8.8e-14 51.6 0.5 1.4 1 0 0 1 1 1 1 S1 RNA binding domain EXOSC1 PF10447.9 ELR18076.1 - 0.0073 16.9 0.2 0.019 15.6 0.1 1.7 1 1 0 1 1 1 1 Exosome component EXOSC1/CSL4 Carot_N PF09150.10 ELR18076.1 - 0.016 15.1 0.0 0.03 14.2 0.0 1.4 1 0 0 1 1 1 0 Orange carotenoid protein, N-terminal Proteasome PF00227.26 ELR18077.1 - 4.2e-57 192.7 0.0 6.8e-57 192.0 0.0 1.3 2 0 0 2 2 2 1 Proteasome subunit Proteasome_A_N PF10584.9 ELR18077.1 - 1e-10 41.1 0.8 2.4e-10 39.9 0.0 2.0 2 0 0 2 2 2 1 Proteasome subunit A N-terminal signature zf-HIT PF04438.16 ELR18078.1 - 1.4e-09 37.6 11.8 2.1e-09 37.1 11.8 1.3 1 0 0 1 1 1 1 HIT zinc finger SHQ1 PF04925.15 ELR18078.1 - 0.00012 21.7 0.0 0.00051 19.6 0.0 2.0 1 1 1 2 2 2 1 SHQ1 protein Cas9_a PF18470.1 ELR18078.1 - 0.032 13.8 0.3 0.087 12.3 0.3 1.8 1 0 0 1 1 1 0 Cas9 alpha-helical lobe domain DUF5347 PF17282.2 ELR18078.1 - 0.068 13.5 3.9 0.044 14.1 1.7 1.8 2 0 0 2 2 2 0 Family of unknown function (DUF5347) MLANA PF14991.6 ELR18078.1 - 0.13 12.5 0.3 0.37 11.1 0.0 1.8 2 0 0 2 2 2 0 Protein melan-A Myc_N PF01056.18 ELR18078.1 - 0.15 11.9 15.7 1.6 8.5 1.7 3.2 3 0 0 3 3 3 0 Myc amino-terminal region zf-3CxxC_2 PF17180.4 ELR18078.1 - 0.85 10.4 6.2 3.5 8.4 6.2 2.1 1 1 0 1 1 1 0 Zinc-binding domain Ank_3 PF13606.6 ELR18079.1 - 2.8e-14 51.8 1.9 0.00052 20.3 0.0 7.8 9 0 0 9 9 9 2 Ankyrin repeat Ank_2 PF12796.7 ELR18079.1 - 1.2e-13 51.4 0.0 2.3e-07 31.3 0.0 4.3 2 1 1 4 4 4 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 ELR18079.1 - 4.5e-11 42.8 0.1 7.8e-06 26.1 0.0 5.7 6 0 0 6 6 6 1 Ankyrin repeats (many copies) Ank_4 PF13637.6 ELR18079.1 - 3.1e-09 37.2 0.1 0.0071 16.9 0.0 5.1 5 0 0 5 5 5 2 Ankyrin repeats (many copies) F-box-like PF12937.7 ELR18079.1 - 5.7e-09 35.7 0.2 1.6e-08 34.3 0.2 1.8 1 0 0 1 1 1 1 F-box-like Ank PF00023.30 ELR18079.1 - 2.1e-07 31.0 0.4 0.072 13.6 0.0 6.0 7 1 0 7 7 7 2 Ankyrin repeat F-box PF00646.33 ELR18079.1 - 0.00016 21.4 0.1 0.00043 20.1 0.1 1.7 1 0 0 1 1 1 1 F-box domain Actin PF00022.19 ELR18080.1 - 1.1e-138 462.2 0.0 5.2e-138 460.1 0.0 1.8 1 1 0 1 1 1 1 Actin Methyltransf_29 PF03141.16 ELR18080.1 - 0.17 10.4 0.0 0.24 9.9 0.0 1.1 1 0 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase Methyltransf_11 PF08241.12 ELR18081.1 - 0.00066 20.3 0.0 0.00085 19.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ELR18081.1 - 0.027 15.1 0.0 0.041 14.6 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain HtrL_YibB PF09612.10 ELR18082.1 - 1.9e-07 30.9 0.0 6.1e-07 29.2 0.0 1.6 1 1 0 1 1 1 1 Bacterial protein of unknown function (HtrL_YibB) DUF2788 PF10981.8 ELR18082.1 - 0.13 12.3 1.2 0.27 11.3 1.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2788) WGG PF10273.9 ELR18083.1 - 0.00013 22.6 0.5 0.00024 21.7 0.5 1.5 1 0 0 1 1 1 1 Pre-rRNA-processing protein TSR2 RRP7 PF12923.7 ELR18083.1 - 0.16 12.1 0.2 0.16 12.1 0.2 2.4 2 1 0 2 2 2 0 Ribosomal RNA-processing protein 7 (RRP7) C-terminal domain Phospholip_B PF04916.13 ELR18084.1 - 3.9e-24 85.1 0.0 4.5e-24 84.9 0.0 1.0 1 0 0 1 1 1 1 Phospholipase B RCC1_2 PF13540.6 ELR18085.1 - 1.7e-11 43.6 39.5 1.6e-06 27.7 1.3 7.1 6 2 0 6 6 6 4 Regulator of chromosome condensation (RCC1) repeat RhoGAP PF00620.27 ELR18087.1 - 2.4e-24 85.9 0.0 4.2e-24 85.1 0.0 1.4 1 0 0 1 1 1 1 RhoGAP domain ATP-synt_10 PF05176.14 ELR18089.1 - 3.8e-18 65.6 0.1 9.4e-18 64.4 0.1 1.5 1 1 0 1 1 1 1 ATP10 protein Toxin_22 PF08092.11 ELR18089.1 - 0.099 12.7 0.4 0.3 11.2 0.4 1.7 1 0 0 1 1 1 0 Magi peptide toxin family Ras PF00071.22 ELR18090.1 - 5.9e-54 182.0 0.0 6.8e-54 181.8 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR18090.1 - 1.8e-30 105.6 0.0 3e-30 104.9 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR18090.1 - 1.6e-11 44.0 0.0 2e-11 43.6 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 ELR18090.1 - 1.7e-06 28.1 0.0 2.7e-06 27.4 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 ELR18090.1 - 3.5e-05 23.3 0.0 4.6e-05 22.9 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 ELR18090.1 - 0.0011 18.9 0.1 1.3 8.9 0.0 2.2 1 1 1 2 2 2 2 RsgA GTPase GTP_EFTU PF00009.27 ELR18090.1 - 0.0086 15.6 0.0 0.015 14.9 0.0 1.4 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain AAA_22 PF13401.6 ELR18090.1 - 0.043 14.1 0.0 0.06 13.6 0.0 1.6 1 1 0 1 1 1 0 AAA domain Septin PF00735.18 ELR18090.1 - 0.047 13.0 0.0 0.079 12.2 0.0 1.2 1 0 0 1 1 1 0 Septin FeoB_N PF02421.18 ELR18090.1 - 0.064 12.8 0.3 6.7 6.2 0.0 3.1 1 1 2 4 4 4 0 Ferrous iron transport protein B AAA_16 PF13191.6 ELR18090.1 - 0.064 13.6 0.0 0.077 13.4 0.0 1.5 1 1 0 1 1 1 0 AAA ATPase domain SNF2_N PF00176.23 ELR18090.1 - 0.066 11.9 0.0 0.089 11.5 0.0 1.2 1 0 0 1 1 1 0 SNF2 family N-terminal domain AAA_29 PF13555.6 ELR18090.1 - 0.084 12.6 0.0 0.2 11.4 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AIG1 PF04548.16 ELR18090.1 - 0.091 12.1 0.0 0.14 11.5 0.0 1.3 1 0 0 1 1 1 0 AIG1 family VirE PF05272.11 ELR18090.1 - 0.093 12.5 0.0 0.17 11.6 0.0 1.3 1 0 0 1 1 1 0 Virulence-associated protein E TniB PF05621.11 ELR18090.1 - 0.14 11.5 0.0 0.23 10.9 0.0 1.2 1 0 0 1 1 1 0 Bacterial TniB protein AAA_7 PF12775.7 ELR18090.1 - 0.16 11.5 0.0 0.25 10.8 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region MFS_1 PF07690.16 ELR18091.1 - 7.1e-40 137.0 44.2 1.2e-28 100.1 18.0 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 ELR18091.1 - 3.1e-12 46.1 18.0 5.3e-12 45.3 2.5 2.3 2 0 0 2 2 2 2 Sugar (and other) transporter MFS_1_like PF12832.7 ELR18091.1 - 0.0029 16.5 0.8 0.0029 16.5 0.8 2.5 2 1 0 2 2 2 1 MFS_1 like family PsaL PF02605.15 ELR18091.1 - 0.28 10.8 4.5 2.4 7.8 0.4 3.0 3 0 0 3 3 3 0 Photosystem I reaction centre subunit XI Ion_trans PF00520.31 ELR18092.1 - 0.00075 18.8 6.8 0.001 18.3 6.8 1.2 1 0 0 1 1 1 1 Ion transport protein ATP-synt_DE_N PF02823.16 ELR18093.1 - 2.3e-13 49.8 0.0 3.8e-13 49.2 0.0 1.4 1 0 0 1 1 1 1 ATP synthase, Delta/Epsilon chain, beta-sandwich domain ATP-synt_ab PF00006.25 ELR18094.1 - 6.4e-56 189.4 0.0 9.4e-56 188.8 0.0 1.3 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_N PF02874.23 ELR18094.1 - 5.9e-21 74.8 0.1 1.3e-20 73.7 0.1 1.6 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain AAA_16 PF13191.6 ELR18094.1 - 3.2e-05 24.4 0.1 0.0015 18.9 0.0 2.7 2 0 0 2 2 2 1 AAA ATPase domain NB-ARC PF00931.22 ELR18094.1 - 0.0043 16.3 1.0 0.03 13.5 0.1 2.1 2 0 0 2 2 2 1 NB-ARC domain AAA PF00004.29 ELR18094.1 - 0.03 14.7 0.2 0.5 10.8 0.0 2.6 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Phage_pRha PF09669.10 ELR18094.1 - 0.037 14.6 1.3 0.23 12.1 0.0 2.7 2 0 0 2 2 2 0 Phage regulatory protein Rha (Phage_pRha) RNA_helicase PF00910.22 ELR18094.1 - 0.2 12.1 0.0 0.52 10.7 0.0 1.7 1 0 0 1 1 1 0 RNA helicase AAA_19 PF13245.6 ELR18094.1 - 0.21 11.9 1.4 0.44 10.9 0.2 2.0 2 0 0 2 2 2 0 AAA domain Med2 PF11214.8 ELR18094.1 - 0.49 10.6 2.6 36 4.6 0.0 2.5 2 0 0 2 2 2 0 Mediator complex subunit 2 Pkinase_Tyr PF07714.17 ELR18095.1 - 3.9e-58 196.8 0.0 5.6e-58 196.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ELR18095.1 - 7.7e-39 133.6 0.0 1.3e-38 132.9 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain SPC25 PF06703.11 ELR18096.1 - 8.4e-31 106.9 0.0 9.7e-31 106.7 0.0 1.0 1 0 0 1 1 1 1 Microsomal signal peptidase 25 kDa subunit (SPC25) Tmemb_9 PF05434.11 ELR18096.1 - 0.15 11.9 0.0 0.23 11.4 0.0 1.3 1 0 0 1 1 1 0 TMEM9 RCC1 PF00415.18 ELR18097.1 - 4.2e-28 97.7 11.8 2.6e-10 40.8 0.0 6.6 5 2 0 5 5 5 5 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 ELR18097.1 - 2.4e-18 65.4 18.3 2.2e-06 27.3 2.0 6.4 6 0 0 6 6 6 5 Regulator of chromosome condensation (RCC1) repeat NARP1 PF12569.8 ELR18097.1 - 0.26 10.1 39.7 0.59 9.0 16.8 3.4 3 0 0 3 3 3 0 NMDA receptor-regulated protein 1 CLPTM1 PF05602.12 ELR18098.1 - 7.3e-149 496.4 0.1 8.7e-149 496.2 0.1 1.0 1 0 0 1 1 1 1 Cleft lip and palate transmembrane protein 1 (CLPTM1) PQ-loop PF04193.14 ELR18098.1 - 0.0099 15.6 1.9 1.9 8.3 0.2 2.9 2 0 0 2 2 2 2 PQ loop repeat UQ_con PF00179.26 ELR18099.1 - 1.4e-36 125.2 0.0 2.2e-36 124.6 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 ELR18099.1 - 0.019 15.2 0.1 0.029 14.6 0.1 1.3 1 0 0 1 1 1 0 RWD domain Prok-E2_B PF14461.6 ELR18099.1 - 0.02 14.6 0.0 0.028 14.1 0.0 1.4 1 0 0 1 1 1 0 Prokaryotic E2 family B DUF4407 PF14362.6 ELR18099.1 - 1.1 8.5 4.4 1.5 8.1 4.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) zf-rbx1 PF12678.7 ELR18101.1 - 1.9e-25 88.9 12.9 2.9e-25 88.3 12.9 1.3 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 ELR18101.1 - 2.1e-17 63.0 10.3 2.7e-17 62.6 10.3 1.1 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_2 PF13639.6 ELR18101.1 - 2.3e-06 27.8 14.8 8.3e-05 22.8 14.8 2.3 1 1 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 ELR18101.1 - 6.8e-05 22.6 3.4 6.8e-05 22.6 3.4 2.4 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 ELR18101.1 - 0.0012 18.7 11.6 0.018 14.9 11.6 2.4 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 ELR18101.1 - 0.21 11.5 11.1 0.55 10.1 4.6 2.6 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 ELR18101.1 - 0.24 11.2 15.6 21 5.0 15.6 2.4 1 1 0 1 1 1 0 RING-like zinc finger Zn_ribbon_17 PF17120.5 ELR18101.1 - 0.38 10.4 15.3 0.069 12.8 5.0 2.3 1 1 1 2 2 2 0 Zinc-ribbon, C4HC2 type zf-RING_UBOX PF13445.6 ELR18101.1 - 0.47 10.5 7.9 1.7 8.8 7.9 2.0 1 1 0 1 1 1 0 RING-type zinc-finger FANCL_C PF11793.8 ELR18101.1 - 0.47 10.7 9.2 2.4 8.4 9.4 1.9 1 1 1 2 2 2 0 FANCL C-terminal domain zf-RING_5 PF14634.6 ELR18101.1 - 10 6.2 12.6 67 3.6 12.6 2.4 1 1 0 1 1 1 0 zinc-RING finger domain Brix PF04427.18 ELR18102.1 - 4.8e-39 134.5 0.4 1.1e-37 130.1 0.4 2.2 1 1 0 1 1 1 1 Brix domain JLPA PF16668.5 ELR18102.1 - 0.14 11.2 0.0 0.2 10.7 0.0 1.1 1 0 0 1 1 1 0 Adhesin from Campylobacter Cation_efflux PF01545.21 ELR18103.1 - 7e-07 29.2 12.7 8.9e-06 25.6 6.1 2.1 2 0 0 2 2 2 2 Cation efflux family DUF2207 PF09972.9 ELR18103.1 - 0.12 11.1 1.3 0.91 8.2 1.1 2.1 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) VIT1 PF01988.19 ELR18103.1 - 2 8.2 5.7 0.79 9.5 3.0 1.6 1 1 0 2 2 2 0 VIT family DUF3784 PF12650.7 ELR18103.1 - 2.1 8.6 12.4 1.5 9.1 0.2 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF3784) Phage_holin_3_7 PF05449.11 ELR18103.1 - 4.8 7.3 10.4 0.17 11.9 0.8 2.8 3 1 1 4 4 4 0 Putative 3TM holin, Phage_holin_3 Glyoxalase_4 PF13669.6 ELR18104.1 - 2.7e-22 79.1 0.0 3.7e-22 78.7 0.0 1.2 1 0 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase PF00903.25 ELR18104.1 - 5e-11 42.9 0.0 6.2e-11 42.6 0.0 1.1 1 0 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_3 PF13468.6 ELR18104.1 - 7.7e-07 29.4 0.0 9.5e-07 29.1 0.0 1.1 1 0 0 1 1 1 1 Glyoxalase-like domain Glyoxalase_6 PF18029.1 ELR18104.1 - 0.03 15.1 0.0 0.042 14.6 0.0 1.2 1 0 0 1 1 1 0 Glyoxalase-like domain Glyoxalase_2 PF12681.7 ELR18104.1 - 0.15 12.0 0.0 0.45 10.4 0.0 1.8 1 1 0 1 1 1 0 Glyoxalase-like domain LRR_8 PF13855.6 ELR18105.1 - 1e-64 214.2 62.8 2.4e-10 40.0 1.5 11.5 6 2 6 13 13 13 12 Leucine rich repeat PP2C PF00481.21 ELR18105.1 - 9.5e-55 186.0 0.1 1.4e-54 185.5 0.1 1.2 1 0 0 1 1 1 1 Protein phosphatase 2C LRR_4 PF12799.7 ELR18105.1 - 2e-48 161.5 63.7 8.3e-07 29.2 2.0 13.8 5 3 4 14 14 14 13 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 ELR18105.1 - 1.4e-14 54.0 34.8 2.9e-05 23.6 1.9 7.6 2 2 6 8 8 8 7 Leucine-rich repeat LRR_1 PF00560.33 ELR18105.1 - 1.1e-06 28.3 55.8 12 7.0 0.1 16.5 20 0 0 20 20 20 5 Leucine Rich Repeat PP2C_2 PF13672.6 ELR18105.1 - 2e-05 24.3 1.7 3.8e-05 23.4 1.7 1.4 1 0 0 1 1 1 1 Protein phosphatase 2C RsmF_methylt_CI PF17126.5 ELR18105.1 - 0.0041 17.1 5.8 4 7.5 0.0 7.0 5 3 3 9 9 9 1 RsmF rRNA methyltransferase first C-terminal domain 7tm_2 PF00002.24 ELR18108.1 - 7.7e-08 31.9 26.2 1.2e-06 28.0 25.9 2.5 1 1 0 1 1 1 1 7 transmembrane receptor (Secretin family) 7tm_1 PF00001.21 ELR18108.1 - 0.00038 19.9 24.1 0.0025 17.2 24.1 2.1 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) PIRT PF15099.6 ELR18108.1 - 0.0036 16.9 0.0 0.0094 15.5 0.0 1.6 1 0 0 1 1 1 1 Phosphoinositide-interacting protein family GPR_Gpa2_C PF11970.8 ELR18108.1 - 0.067 13.3 0.4 0.067 13.3 0.4 2.6 3 0 0 3 3 3 0 G protein-coupled glucose receptor regulating Gpa2 C-term DUF2208 PF09973.9 ELR18108.1 - 0.61 9.7 0.0 0.61 9.7 0.0 2.8 3 0 0 3 3 3 0 Predicted membrane protein (DUF2208) Choline_kinase PF01633.20 ELR18109.1 - 1.7e-53 181.3 0.0 2.6e-53 180.8 0.0 1.2 1 0 0 1 1 1 1 Choline/ethanolamine kinase APH PF01636.23 ELR18109.1 - 2.7e-09 37.3 0.0 4.1e-09 36.7 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family EcKinase PF02958.20 ELR18109.1 - 4.7e-09 36.0 0.5 1.1e-06 28.2 0.5 2.7 2 1 0 2 2 2 1 Ecdysteroid kinase DUF1679 PF07914.11 ELR18109.1 - 0.026 13.4 0.0 0.038 12.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1679) DUF1569 PF07606.11 ELR18109.1 - 0.1 12.6 0.0 10 6.1 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1569) WD40 PF00400.32 ELR18110.1 - 5.1e-37 125.2 25.7 6.6e-09 36.3 0.2 7.1 6 1 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ELR18110.1 - 2.8e-11 43.6 0.6 0.001 19.3 0.1 4.9 1 1 3 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ELR18110.1 - 1.8e-08 34.1 0.2 2.1e-05 24.0 0.0 3.1 2 1 1 3 3 3 3 WD40-like domain F-box-like PF12937.7 ELR18110.1 - 1.9e-08 34.1 2.8 3.7e-08 33.1 2.8 1.5 1 0 0 1 1 1 1 F-box-like Nup160 PF11715.8 ELR18110.1 - 2.7e-06 26.4 12.4 0.15 10.7 0.0 5.5 3 2 2 6 6 6 4 Nucleoporin Nup120/160 F-box PF00646.33 ELR18110.1 - 0.0087 15.9 2.3 0.023 14.6 2.3 1.7 1 0 0 1 1 1 1 F-box domain DUF1513 PF07433.11 ELR18110.1 - 0.086 11.9 0.0 3 6.8 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1513) PQQ PF01011.21 ELR18110.1 - 0.12 12.3 0.3 14 5.9 0.1 3.4 3 0 0 3 3 3 0 PQQ enzyme repeat PQQ_2 PF13360.6 ELR18111.1 - 1.9e-09 37.4 0.4 1.7e-07 31.1 0.0 2.6 1 1 0 2 2 2 1 PQQ-like domain F-box-like PF12937.7 ELR18111.1 - 5.8e-08 32.5 0.8 1.3e-07 31.4 0.8 1.6 1 0 0 1 1 1 1 F-box-like PQQ PF01011.21 ELR18111.1 - 2.6e-06 27.1 0.0 0.013 15.4 0.0 2.7 2 0 0 2 2 2 2 PQQ enzyme repeat F-box PF00646.33 ELR18111.1 - 6.7e-06 25.9 0.4 1.3e-05 24.9 0.4 1.5 1 0 0 1 1 1 1 F-box domain F-box_4 PF15966.5 ELR18111.1 - 0.00072 19.4 0.0 0.00072 19.4 0.0 2.1 2 0 0 2 2 2 1 F-box Elongin_A PF06881.11 ELR18111.1 - 0.0015 19.0 0.6 0.004 17.7 0.1 1.9 2 0 0 2 2 2 1 RNA polymerase II transcription factor SIII (Elongin) subunit A DHHC PF01529.20 ELR18112.1 - 1.8 8.7 2.6 2.8 8.1 2.6 1.3 1 0 0 1 1 1 0 DHHC palmitoyltransferase GATase_4 PF13230.6 ELR18113.1 - 7.5e-14 51.3 0.4 3.9e-12 45.7 0.4 2.2 1 1 0 1 1 1 1 Glutamine amidotransferases class-II GATase_6 PF13522.6 ELR18113.1 - 1.8e-08 34.6 0.1 3.9e-08 33.6 0.1 1.7 1 0 0 1 1 1 1 Glutamine amidotransferase domain Synaptobrevin PF00957.21 ELR18114.1 - 3.3e-18 65.3 0.6 6.6e-18 64.3 0.6 1.5 1 0 0 1 1 1 1 Synaptobrevin Longin PF13774.6 ELR18114.1 - 2.9e-17 62.5 0.3 5.1e-17 61.7 0.3 1.4 1 0 0 1 1 1 1 Regulated-SNARE-like domain LMBR1 PF04791.16 ELR18114.1 - 0.006 15.5 0.3 0.0075 15.2 0.3 1.1 1 0 0 1 1 1 1 LMBR1-like membrane protein Macoilin PF09726.9 ELR18115.1 - 3.8 5.9 18.3 5 5.5 18.3 1.1 1 0 0 1 1 1 0 Macoilin family P16-Arc PF04699.14 ELR18116.1 - 1.4e-31 110.0 0.0 1.5e-31 109.9 0.0 1.0 1 0 0 1 1 1 1 ARP2/3 complex 16 kDa subunit (p16-Arc) Utp12 PF04003.12 ELR18116.1 - 0.0028 17.9 0.0 0.0055 17.0 0.0 1.4 2 0 0 2 2 2 1 Dip2/Utp12 Family NTP_transferase PF00483.23 ELR18117.1 - 1.9e-18 67.0 0.0 1.2e-16 61.1 0.0 2.3 1 1 1 2 2 2 1 Nucleotidyl transferase NTP_transf_3 PF12804.7 ELR18117.1 - 1.1e-11 45.4 0.0 1.9e-11 44.6 0.0 1.5 1 1 0 1 1 1 1 MobA-like NTP transferase domain Hexapep PF00132.24 ELR18117.1 - 5.8e-08 32.2 17.3 0.0024 17.6 0.1 3.1 1 1 1 3 3 3 2 Bacterial transferase hexapeptide (six repeats) DUF4954 PF16314.5 ELR18117.1 - 0.0066 14.6 1.5 0.011 13.9 1.5 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4954) Fucokinase PF07959.12 ELR18117.1 - 0.025 13.5 7.9 0.088 11.7 7.9 1.8 1 1 0 1 1 1 0 L-fucokinase IspD PF01128.19 ELR18117.1 - 0.039 13.7 0.0 0.078 12.7 0.0 1.5 1 0 0 1 1 1 0 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase CTP_transf_3 PF02348.19 ELR18117.1 - 0.059 13.3 0.0 0.1 12.5 0.0 1.3 1 0 0 1 1 1 0 Cytidylyltransferase Hexapep_2 PF14602.6 ELR18117.1 - 0.24 11.2 0.0 0.24 11.2 0.0 3.7 2 1 0 2 2 2 0 Hexapeptide repeat of succinyl-transferase CENP-I PF07778.11 ELR18119.1 - 7.5e-30 104.1 3.2 1.4e-15 57.0 0.2 3.1 2 1 0 2 2 2 2 Mis6 HEAT_UF PF18817.1 ELR18119.1 - 0.11 12.7 0.0 0.36 11.1 0.0 1.9 1 0 0 1 1 1 0 Repeat of uncharacterized protein PH0542 Rad51 PF08423.11 ELR18120.1 - 3.4e-45 154.3 0.0 3.8e-43 147.6 0.0 2.1 2 0 0 2 2 2 2 Rad51 AAA_25 PF13481.6 ELR18120.1 - 6.5e-09 35.7 0.0 1.1e-08 34.9 0.0 1.3 1 0 0 1 1 1 1 AAA domain ATPase PF06745.13 ELR18120.1 - 3.5e-08 33.1 0.2 2.4e-07 30.3 0.2 2.0 1 1 0 1 1 1 1 KaiC RecA PF00154.21 ELR18120.1 - 3.6e-07 29.9 2.0 0.011 15.3 0.4 2.1 2 0 0 2 2 2 2 recA bacterial DNA recombination protein DnaB_C PF03796.15 ELR18120.1 - 5.5e-07 29.2 0.5 0.0011 18.3 0.6 2.1 2 0 0 2 2 2 2 DnaB-like helicase C terminal domain AAA_22 PF13401.6 ELR18120.1 - 0.0054 17.0 0.1 0.017 15.4 0.1 1.8 1 1 0 1 1 1 1 AAA domain DUF2075 PF09848.9 ELR18120.1 - 0.0066 15.7 0.0 0.014 14.7 0.0 1.5 1 1 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) PhoH PF02562.16 ELR18120.1 - 0.12 11.9 0.0 0.21 11.0 0.0 1.3 1 0 0 1 1 1 0 PhoH-like protein ELMO_CED12 PF04727.13 ELR18121.1 - 1.6e-50 171.7 0.3 4.5e-50 170.2 0.3 1.7 1 0 0 1 1 1 1 ELMO/CED-12 family DUF3361 PF11841.8 ELR18121.1 - 5.8e-19 68.5 0.3 1.3e-18 67.5 0.3 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3361) PH_12 PF16457.5 ELR18121.1 - 4.6e-14 53.1 0.0 1e-13 52.0 0.0 1.6 1 0 0 1 1 1 1 Pleckstrin homology domain DUF4042 PF13251.6 ELR18121.1 - 0.026 14.2 0.9 0.13 11.9 0.0 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF4042) Proteasom_PSMB PF10508.9 ELR18121.1 - 0.032 12.7 0.6 0.91 7.9 0.0 2.6 2 2 1 3 3 3 0 Proteasome non-ATPase 26S subunit Tti2 PF10521.9 ELR18121.1 - 0.1 12.1 1.6 0.2 11.2 0.4 1.9 2 0 0 2 2 2 0 Tti2 family Sec3-PIP2_bind PF15277.6 ELR18121.1 - 0.1 12.7 0.2 0.3 11.2 0.2 1.8 1 0 0 1 1 1 0 Exocyst complex component SEC3 N-terminal PIP2 binding PH C2 PF00168.30 ELR18122.1 - 5.7e-09 36.2 0.0 2.3e-08 34.3 0.0 2.0 2 0 0 2 2 2 1 C2 domain Smg8_Smg9 PF10220.9 ELR18123.1 - 0.004 15.6 0.0 0.0056 15.1 0.0 1.3 1 0 0 1 1 1 1 Smg8_Smg9 ABC_tran PF00005.27 ELR18123.1 - 0.024 15.2 0.0 0.048 14.2 0.0 1.6 1 0 0 1 1 1 0 ABC transporter MMR_HSR1 PF01926.23 ELR18123.1 - 0.039 14.0 0.2 0.12 12.5 0.0 1.9 2 0 0 2 2 2 0 50S ribosome-binding GTPase CbiA PF01656.23 ELR18123.1 - 0.076 13.1 0.0 0.12 12.4 0.0 1.4 1 0 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain Ploopntkinase3 PF18751.1 ELR18123.1 - 0.14 12.1 0.0 0.68 9.8 0.0 2.0 2 0 0 2 2 2 0 P-loop Nucleotide Kinase3 LBP_BPI_CETP_C PF02886.17 ELR18124.1 - 8.2e-27 94.2 0.1 1.2e-26 93.6 0.1 1.2 1 0 0 1 1 1 1 LBP / BPI / CETP family, C-terminal domain LBP_BPI_CETP PF01273.25 ELR18124.1 - 2.3e-12 46.9 0.1 7e-12 45.3 0.0 1.7 2 0 0 2 2 2 1 LBP / BPI / CETP family, N-terminal domain PI-PLC-X PF00388.19 ELR18125.1 - 4.3e-56 188.5 0.0 8.6e-56 187.5 0.0 1.5 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y PF00387.19 ELR18125.1 - 7.4e-37 126.2 0.8 1.8e-36 125.0 0.1 2.1 2 0 0 2 2 2 1 Phosphatidylinositol-specific phospholipase C, Y domain C2 PF00168.30 ELR18125.1 - 2.9e-13 50.0 0.0 8e-13 48.6 0.0 1.7 1 0 0 1 1 1 1 C2 domain EF-hand_8 PF13833.6 ELR18125.1 - 1.4e-07 31.2 0.4 1.1e-05 25.2 0.0 2.6 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_like PF09279.11 ELR18125.1 - 8.2e-07 29.4 0.4 8.2e-07 29.4 0.4 3.3 3 0 0 3 3 3 1 Phosphoinositide-specific phospholipase C, efhand-like EF-hand_7 PF13499.6 ELR18125.1 - 1.8e-05 25.1 5.3 0.00041 20.7 0.0 3.7 3 0 0 3 3 3 1 EF-hand domain pair EF-hand_1 PF00036.32 ELR18125.1 - 2.9e-05 23.3 0.2 0.00034 19.9 0.0 2.9 3 0 0 3 3 3 1 EF hand PH_12 PF16457.5 ELR18125.1 - 4.8e-05 23.9 0.0 0.00016 22.2 0.0 2.0 1 1 0 1 1 1 1 Pleckstrin homology domain EF-hand_6 PF13405.6 ELR18125.1 - 9.1e-05 22.1 3.0 0.36 10.9 0.0 3.9 4 0 0 4 4 3 2 EF-hand domain EF-hand_10 PF14788.6 ELR18125.1 - 0.0015 18.4 0.2 0.0034 17.2 0.2 1.7 1 0 0 1 1 1 1 EF hand EF-hand_5 PF13202.6 ELR18125.1 - 0.032 13.7 0.0 0.11 12.1 0.0 1.9 1 0 0 1 1 1 0 EF hand RNase_P_p30 PF01876.16 ELR18125.1 - 0.096 12.1 0.0 0.21 11.0 0.0 1.5 1 0 0 1 1 1 0 RNase P subunit p30 AAA_11 PF13086.6 ELR18126.1 - 2.1e-53 181.7 0.2 2.1e-53 181.7 0.2 4.3 3 2 0 3 3 3 1 AAA domain AAA_12 PF13087.6 ELR18126.1 - 7.4e-50 169.3 0.0 7.4e-50 169.3 0.0 2.0 2 0 0 2 2 2 1 AAA domain R3H PF01424.22 ELR18126.1 - 3.6e-11 42.9 0.0 1.3e-10 41.1 0.0 2.1 1 0 0 1 1 1 1 R3H domain zf-AN1 PF01428.16 ELR18126.1 - 3.9e-07 30.1 6.9 7.2e-07 29.3 6.9 1.5 1 0 0 1 1 1 1 AN1-like Zinc finger AAA_19 PF13245.6 ELR18126.1 - 3.2e-05 24.3 0.1 0.00016 22.1 0.0 2.2 2 0 0 2 2 2 1 AAA domain Viral_helicase1 PF01443.18 ELR18126.1 - 0.00014 21.7 0.0 0.18 11.5 0.0 2.7 2 0 0 2 2 2 2 Viral (Superfamily 1) RNA helicase AAA_30 PF13604.6 ELR18126.1 - 0.00038 20.2 6.8 0.041 13.6 1.9 4.5 2 1 0 2 2 2 1 AAA domain Transp_Tc5_C PF04236.15 ELR18126.1 - 0.037 14.4 4.9 0.071 13.5 4.9 1.4 1 0 0 1 1 1 0 Tc5 transposase C-terminal domain UvrD_C_2 PF13538.6 ELR18126.1 - 0.068 13.0 0.0 0.15 11.9 0.0 1.6 1 0 0 1 1 1 0 UvrD-like helicase C-terminal domain RhoGEF PF00621.20 ELR18127.1 - 5.8e-35 121.2 0.4 1.8e-34 119.6 0.4 1.9 1 0 0 1 1 1 1 RhoGEF domain Arm PF00514.23 ELR18127.1 - 2.2e-21 75.1 4.9 3.5e-05 23.7 0.1 8.8 9 1 1 10 10 10 4 Armadillo/beta-catenin-like repeat SAM_1 PF00536.30 ELR18127.1 - 3.5e-09 37.0 0.0 1.1e-08 35.4 0.0 1.8 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 ELR18127.1 - 3.3e-07 30.3 0.1 8.7e-07 29.0 0.1 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Arm_2 PF04826.13 ELR18127.1 - 3.1e-06 26.8 9.1 0.0042 16.6 6.2 5.1 4 1 0 4 4 4 1 Armadillo-like DUF4704 PF15787.5 ELR18127.1 - 0.00017 20.9 0.1 0.11 11.7 0.0 2.5 2 0 0 2 2 2 2 Domain of unknown function (DUF4704) HEAT_EZ PF13513.6 ELR18127.1 - 0.004 17.6 0.8 0.083 13.4 0.1 6.6 7 1 1 8 8 8 2 HEAT-like repeat HEAT_2 PF13646.6 ELR18127.1 - 0.0073 16.7 3.8 1 9.8 0.1 4.9 5 0 0 5 5 5 1 HEAT repeats MMS19_N PF14500.6 ELR18127.1 - 0.016 14.8 0.2 0.34 10.4 0.0 2.3 2 0 0 2 2 2 0 Dos2-interacting transcription regulator of RNA-Pol-II HEAT PF02985.22 ELR18127.1 - 0.41 11.0 5.7 5.7 7.5 0.0 5.1 6 0 0 6 6 5 0 HEAT repeat DUF5578 PF17741.1 ELR18127.1 - 0.66 9.3 5.9 15 4.9 0.6 4.1 4 1 1 5 5 5 0 Family of unknown function (DUF5578) RWP-RK PF02042.15 ELR18128.1 - 0.0021 18.0 0.6 0.0037 17.2 0.6 1.4 1 0 0 1 1 1 1 RWP-RK domain HTH_8 PF02954.19 ELR18128.1 - 0.015 15.0 0.0 0.029 14.2 0.0 1.4 1 0 0 1 1 1 0 Bacterial regulatory protein, Fis family HTH_23 PF13384.6 ELR18128.1 - 0.13 12.0 0.1 0.38 10.6 0.1 1.8 1 0 0 1 1 1 0 Homeodomain-like domain ELMO_CED12 PF04727.13 ELR18129.1 - 1.4e-41 142.5 0.1 2.3e-41 141.8 0.1 1.3 1 0 0 1 1 1 1 ELMO/CED-12 family Vfa1 PF08432.10 ELR18130.1 - 2.9 8.2 13.7 0.49 10.7 7.3 2.1 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 Zip PF02535.22 ELR18131.1 - 4.9e-49 167.4 8.2 1.7e-48 165.6 8.2 1.7 1 1 0 1 1 1 1 ZIP Zinc transporter DUF5022 PF16425.5 ELR18131.1 - 0.066 12.7 0.0 0.087 12.3 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5022) CCSMST1 PF15013.6 ELR18131.1 - 0.42 10.8 2.2 1.5 9.1 2.2 2.0 1 0 0 1 1 1 0 CCSMST1 family Phage_holin_3_6 PF07332.11 ELR18131.1 - 0.54 10.3 0.0 0.54 10.3 0.0 3.2 3 1 1 4 4 4 0 Putative Actinobacterial Holin-X, holin superfamily III Mito_carr PF00153.27 ELR18132.1 - 1.1e-52 175.9 0.3 4.5e-19 68.2 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein GST_N_4 PF17172.4 ELR18133.1 - 1.2e-17 64.4 0.0 2e-17 63.7 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase N-terminal domain GST_C_6 PF17171.4 ELR18133.1 - 2.4e-14 52.9 0.0 4.5e-14 52.0 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Tom37 PF10568.9 ELR18133.1 - 1.5e-07 31.8 0.0 2.3e-07 31.2 0.0 1.3 1 0 0 1 1 1 1 Outer mitochondrial membrane transport complex protein GST_C_2 PF13410.6 ELR18133.1 - 4.3e-06 26.6 0.0 1.1e-05 25.4 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 ELR18133.1 - 7e-06 26.4 0.0 6.8e-05 23.2 0.0 2.4 2 1 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 ELR18133.1 - 0.003 17.7 0.0 0.065 13.4 0.0 2.2 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 ELR18133.1 - 0.045 14.0 0.0 0.08 13.2 0.0 1.5 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain Pkinase PF00069.25 ELR18134.1 - 2e-58 197.8 0.0 2e-58 197.8 0.0 3.9 2 2 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR18134.1 - 1.1e-36 126.4 8.7 1e-23 83.9 0.0 3.9 4 0 0 4 4 4 2 Protein tyrosine kinase MMR_HSR1 PF01926.23 ELR18135.1 - 4.7e-15 55.7 0.0 2.6e-13 50.1 0.0 2.2 2 0 0 2 2 2 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 ELR18135.1 - 0.00028 20.5 0.0 0.018 14.6 0.0 2.3 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 ELR18135.1 - 0.00033 20.6 0.1 0.0019 18.1 0.1 2.1 1 1 0 1 1 1 1 RsgA GTPase FeoB_N PF02421.18 ELR18135.1 - 0.0021 17.6 0.2 0.029 13.9 0.1 2.6 2 1 0 2 2 2 1 Ferrous iron transport protein B Septin PF00735.18 ELR18135.1 - 0.0076 15.6 0.0 0.012 15.0 0.0 1.3 1 0 0 1 1 1 1 Septin AAA_18 PF13238.6 ELR18135.1 - 0.039 14.5 0.0 0.11 13.1 0.0 1.8 2 0 0 2 2 2 0 AAA domain ATP_bind_1 PF03029.17 ELR18135.1 - 0.11 12.2 0.0 3.2 7.5 0.0 2.3 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein Roc PF08477.13 ELR18135.1 - 0.11 12.7 0.0 0.21 11.8 0.0 1.4 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase Dynamin_N PF00350.23 ELR18135.1 - 0.19 11.8 0.0 28 4.7 0.0 2.4 2 0 0 2 2 2 0 Dynamin family RNA_helicase PF00910.22 ELR18135.1 - 0.21 12.0 0.0 0.53 10.7 0.0 1.7 1 0 0 1 1 1 0 RNA helicase Arf PF00025.21 ELR18135.1 - 0.22 11.0 0.0 0.4 10.1 0.0 1.3 1 0 0 1 1 1 0 ADP-ribosylation factor family Acyltransferase PF01553.21 ELR18136.1 - 1.2e-21 76.8 0.0 2.4e-21 75.8 0.0 1.5 1 0 0 1 1 1 1 Acyltransferase EF-hand_1 PF00036.32 ELR18137.1 - 1.2e-22 77.7 11.9 7.9e-08 31.3 0.6 4.5 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.6 ELR18137.1 - 4.7e-20 69.7 5.9 4.6e-05 23.0 0.1 4.5 4 0 0 4 4 4 4 EF-hand domain EF-hand_7 PF13499.6 ELR18137.1 - 5.9e-18 65.1 7.5 1.2e-10 41.6 1.0 3.1 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.6 ELR18137.1 - 5.7e-14 50.9 14.4 3.2e-05 23.2 0.7 4.1 5 0 0 5 5 5 3 EF hand EF-hand_8 PF13833.6 ELR18137.1 - 1.4e-12 47.3 9.4 0.00014 21.6 0.1 3.8 4 0 0 4 4 4 3 EF-hand domain pair EF-hand_4 PF12763.7 ELR18137.1 - 2.8e-07 30.4 3.4 0.02 14.9 0.0 3.1 1 1 2 3 3 3 2 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.6 ELR18137.1 - 0.00019 21.7 1.2 0.27 11.6 0.0 3.9 2 2 1 4 4 4 1 EF-hand domain Caleosin PF05042.13 ELR18137.1 - 0.0047 16.9 1.6 16 5.4 0.1 3.3 1 1 2 3 3 3 0 Caleosin related protein EF-hand_10 PF14788.6 ELR18137.1 - 0.022 14.6 3.9 12 5.9 0.1 3.5 3 1 0 3 3 3 0 EF hand SPARC_Ca_bdg PF10591.9 ELR18137.1 - 0.025 14.9 1.6 23 5.4 0.0 3.1 2 1 0 3 3 3 0 Secreted protein acidic and rich in cysteine Ca binding region RNA_pol_Rpb5_N PF03871.14 ELR18137.1 - 0.038 14.6 0.7 0.13 12.8 0.1 2.1 3 0 0 3 3 3 0 RNA polymerase Rpb5, N-terminal domain EspA PF03433.13 ELR18137.1 - 0.062 13.1 0.5 0.092 12.6 0.5 1.4 1 1 0 1 1 1 0 EspA-like secreted protein p25-alpha PF05517.12 ELR18137.1 - 0.24 11.6 4.6 0.8 9.9 0.2 2.7 1 1 1 2 2 2 0 p25-alpha SDA1 PF05285.12 ELR18138.1 - 0.5 9.7 9.9 0.65 9.4 9.9 1.1 1 0 0 1 1 1 0 SDA1 BLOC1S3 PF15753.5 ELR18138.1 - 0.56 10.3 29.7 97 3.0 4.6 3.1 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex 1 subunit 3 DUF2457 PF10446.9 ELR18138.1 - 1.5 7.8 9.8 1.7 7.7 9.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) PFK PF00365.20 ELR18139.1 - 1.5e-34 119.7 0.2 8.5e-34 117.2 0.2 2.0 1 1 0 1 1 1 1 Phosphofructokinase FH2 PF02181.23 ELR18140.1 - 2.2e-96 323.2 0.1 2.2e-96 323.2 0.1 2.2 2 1 0 2 2 2 1 Formin Homology 2 Domain Drf_FH3 PF06367.16 ELR18140.1 - 4.6e-35 121.0 1.0 4.6e-35 121.0 1.0 2.1 2 1 0 2 2 2 1 Diaphanous FH3 Domain Drf_GBD PF06371.13 ELR18140.1 - 8.7e-17 61.3 0.0 1.9e-16 60.2 0.0 1.6 1 0 0 1 1 1 1 Diaphanous GTPase-binding Domain FlaC_arch PF05377.11 ELR18140.1 - 0.00074 19.9 4.9 1 9.8 0.0 3.8 3 0 0 3 3 3 2 Flagella accessory protein C (FlaC) Proteasom_PSMB PF10508.9 ELR18140.1 - 0.028 12.9 0.2 1.1 7.6 0.1 2.4 2 0 0 2 2 2 0 Proteasome non-ATPase 26S subunit Telomere_reg-2 PF10193.9 ELR18140.1 - 0.17 12.3 0.6 7.7 7.0 0.2 3.1 2 0 0 2 2 2 0 Telomere length regulation protein HI0933_like PF03486.14 ELR18141.1 - 5.3e-67 226.3 0.0 6e-67 226.1 0.0 1.0 1 0 0 1 1 1 1 HI0933-like protein DAO PF01266.24 ELR18141.1 - 0.0062 16.2 0.0 0.018 14.7 0.0 1.6 1 1 0 2 2 2 1 FAD dependent oxidoreductase Amino_oxidase PF01593.24 ELR18141.1 - 0.056 12.7 0.0 0.2 10.9 0.0 1.7 2 0 0 2 2 2 0 Flavin containing amine oxidoreductase Pyr_redox_2 PF07992.14 ELR18141.1 - 0.098 11.9 0.0 0.16 11.2 0.0 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase AA_permease_2 PF13520.6 ELR18142.1 - 3.1e-37 128.4 32.9 4e-37 128.1 32.9 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 ELR18142.1 - 1.1e-23 83.7 30.4 2e-23 82.8 30.4 1.3 1 1 0 1 1 1 1 Amino acid permease MMM1 PF10296.9 ELR18143.1 - 0.0084 15.2 0.1 0.04 13.0 0.1 2.0 1 1 0 1 1 1 1 Maintenance of mitochondrial morphology protein 1 Muted PF14942.6 ELR18144.1 - 1.4e-12 48.2 3.0 1.7e-12 47.9 3.0 1.0 1 0 0 1 1 1 1 Organelle biogenesis, Muted-like protein Glyco_transf_20 PF00982.21 ELR18145.1 - 4.4e-171 569.7 0.0 5.4e-171 569.4 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 20 Trehalose_PPase PF02358.16 ELR18145.1 - 4.4e-25 88.2 0.0 9.4e-25 87.1 0.0 1.5 1 1 0 1 1 1 1 Trehalose-phosphatase Glycos_transf_1 PF00534.20 ELR18145.1 - 0.2 11.2 0.1 4.4 6.8 0.1 2.8 2 1 0 2 2 2 0 Glycosyl transferases group 1 dCMP_cyt_deam_1 PF00383.23 ELR18146.1 - 7.4e-10 38.6 1.2 2.3e-05 24.2 0.2 2.3 1 1 1 2 2 2 2 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 ELR18146.1 - 7.6e-09 35.4 0.8 6.1e-05 22.8 0.0 2.2 1 1 1 2 2 2 2 MafB19-like deaminase Bd3614-deam PF14439.6 ELR18146.1 - 0.004 17.2 0.0 0.021 14.9 0.1 2.0 1 1 1 2 2 2 1 Bd3614-like deaminase ABC2_membrane PF01061.24 ELR18147.1 - 1.3e-37 129.3 23.8 1.3e-37 129.3 23.8 1.6 2 0 0 2 2 2 1 ABC-2 type transporter ABC_tran PF00005.27 ELR18147.1 - 1.7e-25 90.1 0.0 3e-25 89.3 0.0 1.4 1 0 0 1 1 1 1 ABC transporter RsgA_GTPase PF03193.16 ELR18147.1 - 0.00049 20.0 0.1 0.0011 18.9 0.0 1.5 2 0 0 2 2 2 1 RsgA GTPase AAA_22 PF13401.6 ELR18147.1 - 0.0012 19.1 0.0 0.0038 17.5 0.0 1.9 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 ELR18147.1 - 0.0014 19.1 0.0 0.0029 18.0 0.0 1.6 1 1 0 1 1 1 1 AAA ATPase domain SMC_N PF02463.19 ELR18147.1 - 0.0038 16.7 0.1 0.64 9.4 0.0 2.2 2 0 0 2 2 2 1 RecF/RecN/SMC N terminal domain ABC2_membrane_2 PF12679.7 ELR18147.1 - 0.0058 15.9 9.3 0.011 15.0 9.3 1.4 1 0 0 1 1 1 1 ABC-2 family transporter protein AAA_21 PF13304.6 ELR18147.1 - 0.0063 16.4 0.1 0.65 9.8 0.0 2.3 1 1 1 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system RNA_helicase PF00910.22 ELR18147.1 - 0.011 16.1 0.0 0.044 14.2 0.0 2.0 2 0 0 2 2 2 0 RNA helicase NACHT PF05729.12 ELR18147.1 - 0.03 14.2 0.1 0.081 12.8 0.1 1.7 1 0 0 1 1 1 0 NACHT domain AAA_35 PF14516.6 ELR18147.1 - 0.083 11.7 0.0 0.14 11.0 0.0 1.2 1 0 0 1 1 1 0 AAA-like domain MMR_HSR1 PF01926.23 ELR18147.1 - 0.13 12.4 0.0 0.29 11.2 0.0 1.6 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_30 PF13604.6 ELR18147.1 - 0.15 11.8 0.1 0.39 10.4 0.0 1.7 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.6 ELR18147.1 - 0.15 11.6 1.0 0.23 11.0 0.1 1.7 2 0 0 2 2 2 0 AAA domain APS_kinase PF01583.20 ELR18147.1 - 0.18 11.7 0.4 1.1 9.1 0.0 2.2 2 0 0 2 2 2 0 Adenylylsulphate kinase ABC2_membrane_3 PF12698.7 ELR18147.1 - 2.1 7.4 26.6 6.8 5.7 26.6 1.6 1 1 0 1 1 1 0 ABC-2 family transporter protein CIMR PF00878.18 ELR18148.1 - 1.5e-05 25.1 1.3 0.00014 22.0 0.0 2.4 2 1 0 2 2 2 1 Cation-independent mannose-6-phosphate receptor repeat ATG27 PF09451.10 ELR18148.1 - 3e-05 24.0 0.2 7.5e-05 22.7 0.0 1.6 1 1 0 1 1 1 1 Autophagy-related protein 27 PRKCSH_1 PF13015.6 ELR18148.1 - 0.0013 18.4 0.3 0.0022 17.7 0.3 1.3 1 0 0 1 1 1 1 Glucosidase II beta subunit-like protein Metal_resist PF13801.6 ELR18148.1 - 0.14 12.4 1.2 0.33 11.1 1.2 1.6 1 0 0 1 1 1 0 Heavy-metal resistance Cadherin_C_2 PF16492.5 ELR18148.1 - 0.42 11.4 2.0 1.9 9.3 2.0 2.1 1 1 0 1 1 1 0 Cadherin cytoplasmic C-terminal HALZ PF02183.18 ELR18149.1 - 0.16 12.2 2.3 1.3 9.3 0.2 2.6 2 0 0 2 2 2 0 Homeobox associated leucine zipper CheX PF13690.6 ELR18149.1 - 0.19 11.9 2.4 23 5.3 0.0 3.2 3 1 0 3 3 3 0 Chemotaxis phosphatase CheX Med11 PF10280.9 ELR18149.1 - 0.72 10.3 3.8 0.95 9.9 0.1 2.6 2 1 0 3 3 3 0 Mediator complex protein Kelch_1 PF01344.25 ELR18150.1 - 1.4e-70 232.7 2.6 3.5e-14 52.1 0.0 6.4 6 0 0 6 6 6 6 Kelch motif Kelch_6 PF13964.6 ELR18150.1 - 6.7e-51 169.0 0.1 3.5e-09 36.6 0.0 6.3 2 2 4 6 6 6 6 Kelch motif Kelch_2 PF07646.15 ELR18150.1 - 7.3e-32 108.1 0.0 0.00016 21.5 0.0 6.5 6 0 0 6 6 6 5 Kelch motif Kelch_4 PF13418.6 ELR18150.1 - 2.5e-31 107.4 3.3 3e-05 23.9 0.0 6.5 6 0 0 6 6 6 5 Galactose oxidase, central domain Kelch_3 PF13415.6 ELR18150.1 - 1e-25 89.4 12.1 3.1e-05 24.1 0.1 6.3 7 0 0 7 7 7 5 Galactose oxidase, central domain BTB_2 PF02214.22 ELR18150.1 - 1.9e-19 69.8 0.1 3.3e-19 69.0 0.1 1.4 1 0 0 1 1 1 1 BTB/POZ domain Kelch_5 PF13854.6 ELR18150.1 - 3.8e-14 52.3 3.8 0.015 15.3 0.0 5.8 6 0 0 6 6 6 4 Kelch motif BTB_3 PF16017.5 ELR18150.1 - 4.2e-07 30.0 0.0 6.9e-07 29.3 0.0 1.3 1 0 0 1 1 1 1 BTB/POZ domain DUF1668 PF07893.13 ELR18150.1 - 4.6e-06 26.2 0.0 0.1 11.9 0.0 3.2 1 1 2 3 3 3 2 Protein of unknown function (DUF1668) DUF4164 PF13747.6 ELR18150.1 - 0.017 15.3 1.8 0.04 14.2 1.8 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4164) Fzo_mitofusin PF04799.13 ELR18150.1 - 0.088 12.4 0.1 0.15 11.6 0.1 1.3 1 0 0 1 1 1 0 fzo-like conserved region Peptidase_M24 PF00557.24 ELR18151.1 - 7.1e-46 156.5 0.0 8.1e-46 156.3 0.0 1.0 1 0 0 1 1 1 1 Metallopeptidase family M24 Glu-tRNAGln PF02686.15 ELR18152.1 - 6.9e-14 51.9 0.2 1.5e-12 47.6 0.2 2.1 1 1 0 1 1 1 1 Glu-tRNAGln amidotransferase C subunit Glyco_transf_20 PF00982.21 ELR18153.1 - 2.9e-137 458.2 0.0 8.8e-137 456.6 0.0 1.6 1 1 0 1 1 1 1 Glycosyltransferase family 20 Trehalose_PPase PF02358.16 ELR18153.1 - 6.1e-67 225.2 0.0 1.1e-66 224.3 0.0 1.4 1 0 0 1 1 1 1 Trehalose-phosphatase Hydrolase_3 PF08282.12 ELR18153.1 - 1.8e-07 31.1 0.0 0.00073 19.4 0.0 2.4 1 1 1 2 2 2 2 haloacid dehalogenase-like hydrolase Usp PF00582.26 ELR18154.1 - 6.4e-26 91.6 0.5 6.4e-26 91.6 0.5 1.9 2 0 0 2 2 2 1 Universal stress protein family DUF4857 PF16149.5 ELR18154.1 - 0.044 13.1 0.0 0.25 10.6 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4857) UCMA PF17085.5 ELR18154.1 - 0.11 12.5 2.5 0.09 12.8 1.2 1.5 2 0 0 2 2 2 0 Unique cartilage matrix associated protein bact-PGI_C PF10432.9 ELR18154.1 - 0.17 12.0 0.8 16 5.5 0.0 2.5 1 1 2 3 3 3 0 Bacterial phospho-glucose isomerase C-terminal SIS domain DEAD PF00270.29 ELR18155.1 - 6.8e-47 159.5 0.0 3.8e-46 157.1 0.0 1.9 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ELR18155.1 - 1.2e-31 109.3 0.0 2.4e-31 108.3 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ERCC3_RAD25_C PF16203.5 ELR18155.1 - 0.041 13.1 0.0 0.06 12.5 0.0 1.2 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase AA_kinase PF00696.28 ELR18155.1 - 0.15 11.6 0.0 0.49 9.9 0.0 2.0 3 0 0 3 3 3 0 Amino acid kinase family TPR_2 PF07719.17 ELR18156.1 - 6.2e-12 44.7 0.5 6.7e-05 22.7 0.0 5.5 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_19 PF14559.6 ELR18156.1 - 1.3e-08 35.2 1.9 0.00018 22.0 0.2 4.1 4 1 0 4 4 3 1 Tetratricopeptide repeat TPR_1 PF00515.28 ELR18156.1 - 3.1e-08 33.1 0.1 0.00013 21.7 0.0 4.1 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_16 PF13432.6 ELR18156.1 - 3.1e-08 34.1 5.0 2.4e-06 28.1 0.2 4.3 4 0 0 4 4 3 1 Tetratricopeptide repeat TPR_14 PF13428.6 ELR18156.1 - 4.7e-08 33.2 4.3 0.23 12.4 0.2 6.3 4 2 1 6 6 5 1 Tetratricopeptide repeat TPR_9 PF13371.6 ELR18156.1 - 2e-06 27.8 4.0 0.0011 19.0 1.2 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.6 ELR18156.1 - 2.8e-06 27.5 2.1 0.17 12.2 0.1 4.5 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_8 PF13181.6 ELR18156.1 - 3.9e-06 26.6 0.0 0.2 11.9 0.0 5.1 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_6 PF13174.6 ELR18156.1 - 7.6e-06 26.2 1.0 0.9 10.3 0.0 4.7 5 0 0 5 5 4 1 Tetratricopeptide repeat TPR_17 PF13431.6 ELR18156.1 - 5.5e-05 23.3 0.0 0.00033 20.8 0.0 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat HrpB1_HrpK PF09613.10 ELR18156.1 - 0.00048 19.8 0.3 0.43 10.2 0.0 4.1 3 1 1 4 4 4 1 Bacterial type III secretion protein (HrpB1_HrpK) Fis1_TPR_C PF14853.6 ELR18156.1 - 0.0014 18.6 0.1 1.2 9.2 0.0 3.4 3 0 0 3 3 3 1 Fis1 C-terminal tetratricopeptide repeat TPR_7 PF13176.6 ELR18156.1 - 0.019 15.0 8.3 10 6.4 0.1 5.4 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_11 PF13414.6 ELR18156.1 - 0.023 14.4 2.7 0.08 12.6 0.0 2.9 4 0 0 4 4 4 0 TPR repeat TPR_10 PF13374.6 ELR18156.1 - 0.038 13.9 0.3 8.5 6.4 0.1 3.8 3 0 0 3 3 3 0 Tetratricopeptide repeat ATP13 PF12921.7 ELR18156.1 - 0.079 12.8 0.0 0.26 11.1 0.0 1.9 1 0 0 1 1 1 0 Mitochondrial ATPase expression Helicase_C_2 PF13307.6 ELR18157.1 - 1.7e-50 171.5 0.0 4.1e-50 170.3 0.0 1.7 1 0 0 1 1 1 1 Helicase C-terminal domain DEAD_2 PF06733.15 ELR18157.1 - 1e-45 155.5 0.0 1.8e-45 154.7 0.0 1.4 1 0 0 1 1 1 1 DEAD_2 PAH PF02671.21 ELR18157.1 - 4.5e-05 23.5 0.6 9.3e-05 22.5 0.6 1.6 1 0 0 1 1 1 1 Paired amphipathic helix repeat CCM2_C PF16545.5 ELR18157.1 - 0.00016 22.1 0.0 0.00045 20.7 0.0 1.7 1 0 0 1 1 1 1 Cerebral cavernous malformation protein, harmonin-homology CENP-B_dimeris PF09026.10 ELR18157.1 - 0.5 10.8 6.3 1.2 9.5 6.3 1.5 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Glyco_hydro_65m PF03632.15 ELR18158.1 - 6.2e-34 117.5 0.3 1.7e-31 109.4 0.2 2.2 1 1 1 2 2 2 2 Glycosyl hydrolase family 65 central catalytic domain DUF2152 PF10222.9 ELR18158.1 - 8.6e-05 21.1 0.0 0.11 10.9 0.0 2.9 3 0 0 3 3 3 2 Uncharacterized conserved protein (DUF2152) Glyco_hydro_65C PF03633.15 ELR18158.1 - 0.026 14.4 0.0 0.065 13.2 0.0 1.7 1 0 0 1 1 1 0 Glycosyl hydrolase family 65, C-terminal domain MORN PF02493.20 ELR18159.1 - 3.2e-25 86.5 59.9 2.8e-07 30.0 1.0 9.5 9 0 0 9 9 9 7 MORN repeat VPS9 PF02204.18 ELR18159.1 - 2.7e-10 40.4 0.0 6.1e-10 39.3 0.0 1.5 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain MFS_1 PF07690.16 ELR18160.1 - 1.1e-23 83.8 48.9 9.6e-16 57.6 17.5 3.1 1 1 2 3 3 3 3 Major Facilitator Superfamily MFS_2 PF13347.6 ELR18160.1 - 5.6e-07 28.5 29.0 0.00061 18.5 29.0 2.6 1 1 0 1 1 1 1 MFS/sugar transport protein HbrB PF08539.11 ELR18160.1 - 0.075 13.0 0.0 0.13 12.3 0.0 1.2 1 0 0 1 1 1 0 HbrB-like PsbN PF02468.15 ELR18160.1 - 4.1 7.3 5.6 1.1 9.1 0.5 2.7 2 0 0 2 2 2 0 Photosystem II reaction centre N protein (psbN) PB1 PF00564.24 ELR18161.1 - 0.00023 21.1 0.4 0.00043 20.1 0.4 1.5 1 0 0 1 1 1 1 PB1 domain Peptidase_C13 PF01650.18 ELR18162.1 - 1.2e-42 146.2 0.5 1.4e-42 146.0 0.5 1.1 1 0 0 1 1 1 1 Peptidase C13 family MGS PF02142.22 ELR18163.1 - 0.0027 17.8 0.1 0.18 12.0 0.0 2.9 3 0 0 3 3 3 1 MGS-like domain Orthopox_C10L PF07020.11 ELR18163.1 - 0.1 13.4 0.1 0.23 12.2 0.1 1.5 1 0 0 1 1 1 0 Orthopoxvirus C10L protein Ribosomal_L23 PF00276.20 ELR18164.1 - 4.3e-18 65.5 0.2 5.7e-18 65.1 0.2 1.1 1 0 0 1 1 1 1 Ribosomal protein L23 Lactamase_B_2 PF12706.7 ELR18165.1 - 1.1e-13 51.2 0.0 3.1e-06 26.9 0.0 2.6 2 1 0 2 2 2 2 Beta-lactamase superfamily domain Lactamase_B PF00753.27 ELR18165.1 - 8.2e-10 39.0 0.6 1.6e-09 38.1 0.1 1.7 2 0 0 2 2 2 1 Metallo-beta-lactamase superfamily Lactamase_B_4 PF13691.6 ELR18165.1 - 0.018 14.7 0.0 0.037 13.7 0.0 1.4 1 0 0 1 1 1 0 tRNase Z endonuclease Dynamin_N PF00350.23 ELR18166.1 - 1.5e-36 126.0 2.3 3.4e-35 121.6 0.0 2.7 3 0 0 3 3 3 1 Dynamin family MMR_HSR1 PF01926.23 ELR18166.1 - 2.8e-05 24.2 0.0 0.00022 21.3 0.0 2.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase TFIIA PF03153.13 ELR18166.1 - 1.7 8.5 25.4 3.5 7.5 25.4 1.4 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit AhpC-TSA PF00578.21 ELR18168.1 - 9.4e-31 106.3 0.0 1.3e-30 105.9 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 ELR18168.1 - 7.8e-14 51.6 0.0 9.9e-14 51.3 0.0 1.2 1 0 0 1 1 1 1 Redoxin 1-cysPrx_C PF10417.9 ELR18168.1 - 8.5e-12 44.7 0.7 2.5e-11 43.2 0.1 2.1 2 0 0 2 2 2 1 C-terminal domain of 1-Cys peroxiredoxin DUF1744 PF08490.12 ELR18169.1 - 1.8e-111 372.6 0.0 3e-111 371.8 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1744) DNA_pol_B_exo1 PF03104.19 ELR18169.1 - 9.8e-74 248.5 0.1 9.8e-74 248.5 0.1 2.0 2 0 0 2 2 2 1 DNA polymerase family B, exonuclease domain DNA_pol_B PF00136.21 ELR18169.1 - 6.4e-16 58.1 6.9 5.5e-10 38.5 0.4 3.9 4 1 0 4 4 4 2 DNA polymerase family B DNA_pol_B_exo2 PF10108.9 ELR18169.1 - 2.6e-07 30.6 0.0 7.5e-07 29.0 0.0 1.8 1 0 0 1 1 1 1 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB RNase_H_2 PF13482.6 ELR18169.1 - 6.2e-05 23.1 0.0 0.00025 21.1 0.0 2.0 2 0 0 2 2 2 1 RNase_H superfamily zf-CHY PF05495.12 ELR18169.1 - 0.33 11.5 5.7 0.96 10.0 5.7 1.8 1 0 0 1 1 1 0 CHY zinc finger Acetyltransf_1 PF00583.25 ELR18170.1 - 3.2e-17 62.9 0.0 4e-17 62.5 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 ELR18170.1 - 2.5e-10 40.6 0.1 3.9e-10 40.0 0.1 1.3 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 ELR18170.1 - 5.2e-10 39.3 0.0 6.6e-10 39.0 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 ELR18170.1 - 1.4e-06 28.5 0.1 1.9e-06 28.1 0.1 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 ELR18170.1 - 0.00021 21.2 0.0 0.00045 20.1 0.0 1.6 1 1 0 1 1 1 1 FR47-like protein Acetyltransf_9 PF13527.7 ELR18170.1 - 0.0016 18.5 0.0 0.0022 18.1 0.0 1.5 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain PUF PF00806.19 ELR18170.1 - 0.056 13.1 0.3 5.3 6.9 0.0 2.5 2 0 0 2 2 2 0 Pumilio-family RNA binding repeat Acetyltransf_18 PF18014.1 ELR18170.1 - 0.11 12.3 0.0 0.17 11.7 0.0 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Pfk_N PF18468.1 ELR18170.1 - 0.12 12.8 0.1 0.21 12.0 0.1 1.4 1 0 0 1 1 1 0 Phosphofructokinase N-terminal domain yeast SSB PF00436.25 ELR18170.1 - 0.14 12.2 0.0 0.87 9.7 0.0 2.2 1 1 0 1 1 1 0 Single-strand binding protein family AAA_28 PF13521.6 ELR18171.1 - 1.4e-05 25.4 0.0 1.8e-05 25.1 0.0 1.2 1 0 0 1 1 1 1 AAA domain RELT PF12606.8 ELR18171.1 - 0.086 11.8 0.0 0.15 11.1 0.0 1.3 1 0 0 1 1 1 0 Tumour necrosis factor receptor superfamily member 19 BHD_2 PF10404.9 ELR18172.1 - 4.9 8.2 7.3 7.8 7.5 7.3 1.7 1 1 0 1 1 1 0 Rad4 beta-hairpin domain 2 Cytomega_UL84 PF06284.11 ELR18172.1 - 7.7 4.8 7.1 10 4.5 7.1 1.1 1 0 0 1 1 1 0 Cytomegalovirus UL84 protein Glyco_transf_54 PF04666.13 ELR18173.1 - 2.8e-09 36.3 0.4 1.1e-05 24.4 0.3 3.1 2 1 0 2 2 2 2 N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region Sprouty PF05210.13 ELR18173.1 - 0.25 11.7 1.1 0.46 10.9 0.0 1.9 2 0 0 2 2 2 0 Sprouty protein (Spry) Urm1 PF09138.11 ELR18174.1 - 4.6e-36 123.1 0.4 5.1e-36 122.9 0.4 1.0 1 0 0 1 1 1 1 Urm1 (Ubiquitin related modifier) ThiS PF02597.20 ELR18174.1 - 2.1e-06 28.3 0.1 2.7e-06 27.9 0.1 1.2 1 0 0 1 1 1 1 ThiS family Glyco_transf_24 PF18404.1 ELR18176.1 - 1.2e-143 477.4 2.2 2e-143 476.6 2.2 1.4 1 0 0 1 1 1 1 Glucosyltransferase 24 Thioredoxin_14 PF18402.1 ELR18176.1 - 1.6e-37 129.9 0.1 8.5e-33 114.4 0.0 3.3 3 0 0 3 3 3 2 Thioredoxin-like domain Thioredoxin_12 PF18400.1 ELR18176.1 - 3.3e-34 118.4 0.1 7.8e-34 117.2 0.1 1.6 1 0 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_15 PF18403.1 ELR18176.1 - 7.8e-30 104.4 0.1 8.9e-24 84.6 0.1 3.0 2 1 0 2 2 2 2 Thioredoxin-like domain Thioredoxin_13 PF18401.1 ELR18176.1 - 2.6e-27 95.4 0.1 6.6e-27 94.1 0.1 1.6 1 0 0 1 1 1 1 Thioredoxin-like domain UDP-g_GGTase PF06427.11 ELR18176.1 - 2.6e-18 66.1 0.0 6.5e-18 64.8 0.0 1.7 1 0 0 1 1 1 1 UDP-glucose:Glycoprotein Glucosyltransferase Glyco_transf_8 PF01501.20 ELR18176.1 - 1e-06 28.5 0.4 2e-06 27.6 0.4 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 8 TPP_enzyme_N PF02776.18 ELR18177.1 - 4.6e-46 156.5 1.6 2.2e-45 154.4 1.0 2.1 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_M PF00205.22 ELR18177.1 - 1.1e-37 128.9 0.1 2.4e-37 127.7 0.1 1.7 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, central domain TPP_enzyme_C PF02775.21 ELR18177.1 - 5.2e-29 101.0 0.5 2e-28 99.1 0.1 2.2 3 0 0 3 3 3 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain CO_dh PF02552.16 ELR18177.1 - 0.0082 15.9 0.0 0.016 15.0 0.0 1.4 1 0 0 1 1 1 1 CO dehydrogenase beta subunit/acetyl-CoA synthase epsilon subunit DXP_synthase_N PF13292.6 ELR18177.1 - 0.009 15.3 0.3 0.015 14.5 0.3 1.3 1 0 0 1 1 1 1 1-deoxy-D-xylulose-5-phosphate synthase mit_SMPDase PF14724.6 ELR18178.1 - 0.72 7.7 3.1 1.1 7.2 3.1 1.1 1 0 0 1 1 1 0 Mitochondrial-associated sphingomyelin phosphodiesterase LSM PF01423.22 ELR18179.1 - 2.7e-23 81.4 0.3 3e-23 81.3 0.3 1.0 1 0 0 1 1 1 1 LSM domain PCNA_N PF00705.18 ELR18180.1 - 7.1e-56 187.4 1.7 2.3e-55 185.7 1.2 1.8 2 0 0 2 2 2 1 Proliferating cell nuclear antigen, N-terminal domain PCNA_C PF02747.15 ELR18180.1 - 1.2e-50 170.9 0.0 6.3e-50 168.6 0.0 1.9 2 0 0 2 2 2 1 Proliferating cell nuclear antigen, C-terminal domain Rad9 PF04139.13 ELR18180.1 - 7.9e-06 25.5 0.0 9.2e-06 25.3 0.0 1.1 1 0 0 1 1 1 1 Rad9 HORMA PF02301.18 ELR18181.1 - 6.7e-18 65.1 1.3 6.7e-18 65.1 1.3 2.3 2 1 1 3 3 3 1 HORMA domain ANAPC2 PF08672.11 ELR18181.1 - 0.0069 16.9 0.0 0.018 15.5 0.0 1.7 1 0 0 1 1 1 1 Anaphase promoting complex (APC) subunit 2 CENP-B_dimeris PF09026.10 ELR18181.1 - 0.013 15.9 0.8 0.032 14.6 0.8 1.7 1 0 0 1 1 1 0 Centromere protein B dimerisation domain DNA_pol_phi PF04931.13 ELR18181.1 - 1.5 6.8 6.4 2.2 6.3 6.4 1.1 1 0 0 1 1 1 0 DNA polymerase phi HA2 PF04408.23 ELR18182.1 - 2.7e-21 75.9 0.0 2.7e-21 75.9 0.0 4.2 4 1 0 4 4 3 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 ELR18182.1 - 5.4e-18 65.1 0.0 1.3e-17 63.9 0.0 1.7 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 ELR18182.1 - 1e-14 54.8 0.0 3.1e-14 53.3 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 ELR18182.1 - 6.4e-06 26.1 0.1 2e-05 24.5 0.1 1.8 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 ELR18182.1 - 0.00029 21.1 0.2 0.0011 19.2 0.2 2.0 1 1 0 1 1 1 1 AAA domain T2SSE PF00437.20 ELR18182.1 - 0.00042 19.5 0.0 0.0008 18.5 0.0 1.4 1 0 0 1 1 1 1 Type II/IV secretion system protein Microtub_bd PF16796.5 ELR18182.1 - 0.0018 18.2 0.2 0.0084 16.0 0.2 2.1 1 0 0 1 1 1 1 Microtubule binding AAA_30 PF13604.6 ELR18182.1 - 0.0041 16.8 0.0 0.011 15.5 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 ELR18182.1 - 0.0089 16.4 0.1 0.025 14.9 0.1 1.8 1 0 0 1 1 1 1 AAA domain AAA_23 PF13476.6 ELR18182.1 - 0.034 14.6 23.9 0.067 13.7 0.0 4.5 5 0 0 5 5 4 0 AAA domain Flavi_DEAD PF07652.14 ELR18182.1 - 0.048 13.6 0.0 0.095 12.7 0.0 1.4 1 0 0 1 1 1 0 Flavivirus DEAD domain ATPase PF06745.13 ELR18182.1 - 0.066 12.6 0.3 0.23 10.8 0.0 2.0 2 0 0 2 2 2 0 KaiC DUF2075 PF09848.9 ELR18182.1 - 0.074 12.3 0.0 0.074 12.3 0.0 3.0 3 0 0 3 3 3 0 Uncharacterized conserved protein (DUF2075) ABC_tran PF00005.27 ELR18182.1 - 0.081 13.4 0.3 0.42 11.1 0.0 2.4 2 1 0 2 2 2 0 ABC transporter cobW PF02492.19 ELR18182.1 - 0.1 12.2 0.2 0.82 9.2 0.1 2.4 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_7 PF12775.7 ELR18182.1 - 0.12 11.9 0.0 0.24 10.9 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region Sigma54_activ_2 PF14532.6 ELR18182.1 - 0.13 12.4 0.0 0.32 11.1 0.0 1.6 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_33 PF13671.6 ELR18182.1 - 0.22 11.7 2.5 0.41 10.8 0.0 2.7 2 1 0 2 2 2 0 AAA domain AAA_16 PF13191.6 ELR18182.1 - 0.23 11.8 1.3 0.77 10.1 0.0 2.4 2 0 0 2 2 2 0 AAA ATPase domain Chorein_N PF12624.7 ELR18183.1 - 6.4e-16 58.5 0.0 6.4e-16 58.5 0.0 2.9 4 0 0 4 4 4 1 N-terminal region of Chorein or VPS13 VPS13 PF16908.5 ELR18183.1 - 3.5e-07 30.3 0.8 0.008 16.0 0.5 3.4 2 1 0 2 2 2 2 Vacuolar sorting-associated protein 13, N-terminal Peptidase_M17 PF00883.21 ELR18184.1 - 6.7e-121 403.3 0.2 8.1e-121 403.1 0.2 1.1 1 0 0 1 1 1 1 Cytosol aminopeptidase family, catalytic domain Peptidase_M17_N PF02789.17 ELR18184.1 - 3.9e-13 49.4 0.0 6.9e-11 42.1 0.0 3.2 2 1 0 2 2 2 1 Cytosol aminopeptidase family, N-terminal domain PAP2 PF01569.21 ELR18186.1 - 1.3e-15 57.3 6.1 1.3e-15 57.3 6.1 3.0 2 2 1 3 3 3 1 PAP2 superfamily PAP2_3 PF14378.6 ELR18186.1 - 0.15 11.8 14.0 1.1 9.0 14.0 2.3 1 1 0 1 1 1 0 PAP2 superfamily PCI PF01399.27 ELR18187.1 - 2.3e-21 76.3 0.0 7.9e-21 74.6 0.0 2.0 1 0 0 1 1 1 1 PCI domain Rpn3_C PF08375.11 ELR18187.1 - 5e-18 65.3 11.7 1.6e-17 63.6 0.4 2.6 2 0 0 2 2 2 1 Proteasome regulatory subunit C-terminal TPR_12 PF13424.6 ELR18187.1 - 0.063 13.6 2.5 0.38 11.1 0.5 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF4890 PF16231.5 ELR18187.1 - 0.094 13.2 0.8 0.51 10.9 0.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4890) FliT PF05400.13 ELR18187.1 - 0.12 13.2 1.6 9.3 7.2 0.4 3.4 3 0 0 3 3 3 0 Flagellar protein FliT TPR_2 PF07719.17 ELR18187.1 - 0.13 12.4 2.0 2.1 8.6 0.1 3.4 4 0 0 4 4 4 0 Tetratricopeptide repeat Glyco_transf_22 PF03901.17 ELR18188.1 - 3.1e-52 178.2 10.3 4.4e-52 177.7 10.3 1.1 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family CsbD PF05532.12 ELR18189.1 - 5.8e-15 54.9 15.6 3.7e-11 42.7 4.0 2.1 1 1 1 2 2 2 2 CsbD-like GreA_GreB_N PF03449.15 ELR18189.1 - 0.047 13.9 2.3 1.6 8.9 0.5 2.8 1 1 2 3 3 3 0 Transcription elongation factor, N-terminal IBR PF01485.21 ELR18190.1 - 4.9e-15 55.5 20.1 6.1e-14 52.0 0.5 3.7 3 1 0 3 3 3 2 IBR domain, a half RING-finger domain zf-RING_UBOX PF13445.6 ELR18190.1 - 1e-06 28.7 11.0 7.6e-05 22.7 3.1 2.9 2 0 0 2 2 2 2 RING-type zinc-finger zf-C3HC4_2 PF13923.6 ELR18190.1 - 4.2e-06 26.5 0.6 4.2e-06 26.5 0.6 4.1 4 0 0 4 4 4 2 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 ELR18190.1 - 0.00044 20.1 18.6 0.083 12.8 4.1 3.5 3 0 0 3 3 3 3 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 ELR18190.1 - 0.00053 20.3 5.9 0.00053 20.3 5.9 4.3 4 1 0 4 4 4 1 Ring finger domain zf-RING_5 PF14634.6 ELR18190.1 - 0.00072 19.5 25.7 0.0032 17.4 6.2 3.4 3 0 0 3 3 3 2 zinc-RING finger domain UIM PF02809.20 ELR18190.1 - 0.0021 17.9 13.0 0.0054 16.6 2.5 4.0 4 0 0 4 4 3 2 Ubiquitin interaction motif zf-C3HC4 PF00097.25 ELR18190.1 - 0.0039 17.0 20.3 0.0051 16.7 2.5 3.6 3 0 0 3 3 3 2 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 ELR18190.1 - 0.046 13.6 16.6 0.11 12.4 1.1 3.7 3 0 0 3 3 3 0 Prokaryotic RING finger family 4 zf-RING_11 PF17123.5 ELR18190.1 - 0.069 12.9 11.0 0.052 13.3 3.9 3.0 2 0 0 2 2 2 0 RING-like zinc finger DZR PF12773.7 ELR18190.1 - 2.5 8.2 17.8 0.22 11.6 5.8 3.1 2 1 1 3 3 3 0 Double zinc ribbon RNA_GG_bind PF10258.9 ELR18191.1 - 3.9e-15 55.7 0.3 8.4e-15 54.6 0.3 1.6 1 0 0 1 1 1 1 PHAX RNA-binding domain HTH_32 PF13565.6 ELR18191.1 - 0.15 12.7 0.4 0.15 12.7 0.4 3.3 4 1 0 4 4 4 0 Homeodomain-like domain Trs65 PF12735.7 ELR18192.1 - 0.00014 21.4 0.0 0.038 13.4 0.1 2.5 2 0 0 2 2 2 2 TRAPP trafficking subunit Trs65 Dynamitin PF04912.14 ELR18193.1 - 4e-77 260.1 23.9 4.8e-77 259.9 23.9 1.0 1 0 0 1 1 1 1 Dynamitin DUF3752 PF12572.8 ELR18193.1 - 0.19 12.2 4.0 0.51 10.9 4.0 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF3752) HalX PF08663.10 ELR18193.1 - 0.53 10.6 9.4 1.6 9.1 4.7 3.7 2 1 1 3 3 3 0 HalX domain COG2 PF06148.11 ELR18193.1 - 4 7.5 16.2 1.9 8.6 0.2 4.1 3 2 1 4 4 4 0 COG (conserved oligomeric Golgi) complex component, COG2 TMPIT PF07851.13 ELR18193.1 - 7.5 5.7 17.2 6.7 5.9 0.9 3.2 2 1 1 3 3 3 0 TMPIT-like protein DUF1128 PF06569.11 ELR18193.1 - 9.4 6.3 9.9 1.2 9.2 0.3 3.7 3 1 1 4 4 4 0 Protein of unknown function (DUF1128) Ras PF00071.22 ELR18195.1 - 3.2e-59 199.2 0.3 3.8e-59 198.9 0.3 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR18195.1 - 7.4e-36 123.0 0.1 1.2e-35 122.4 0.1 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR18195.1 - 1.5e-23 83.2 0.1 1.9e-23 82.8 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 ELR18195.1 - 8.5e-07 28.6 0.2 1.2e-06 28.0 0.2 1.3 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 ELR18195.1 - 1.7e-06 28.0 0.0 3.7e-06 27.0 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 ELR18195.1 - 3.6e-06 26.6 0.6 2e-05 24.2 0.1 2.4 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain SRPRB PF09439.10 ELR18195.1 - 0.0001 21.8 1.2 0.003 17.0 0.0 2.1 1 1 1 2 2 2 1 Signal recognition particle receptor beta subunit RsgA_GTPase PF03193.16 ELR18195.1 - 0.0039 17.1 0.5 2.3 8.1 0.1 2.5 1 1 1 3 3 3 2 RsgA GTPase TniB PF05621.11 ELR18195.1 - 0.014 14.8 0.0 0.025 14.0 0.0 1.3 1 0 0 1 1 1 0 Bacterial TniB protein La PF05383.17 ELR18196.1 - 5.2e-19 68.0 0.1 1.1e-18 67.0 0.1 1.6 1 0 0 1 1 1 1 La domain RRM_1 PF00076.22 ELR18196.1 - 3.3e-14 52.5 0.1 2.1e-12 46.7 0.0 2.7 1 1 1 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) MORN PF02493.20 ELR18197.1 - 6.6e-13 47.7 13.3 0.0022 17.8 0.5 5.7 6 0 0 6 6 6 4 MORN repeat Ras PF00071.22 ELR18198.1 - 1.2e-55 187.5 0.0 1.4e-55 187.3 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR18198.1 - 3.4e-21 75.7 0.0 4.6e-21 75.2 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR18198.1 - 2.9e-08 33.4 0.0 3.5e-08 33.1 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family AIM5 PF17050.5 ELR18198.1 - 0.11 13.3 0.2 3.1 8.7 0.0 2.5 2 1 0 2 2 2 0 Altered inheritance of mitochondria 5 Rnk_N PF14760.6 ELR18198.1 - 0.21 12.1 0.4 1.7 9.2 0.0 2.1 2 0 0 2 2 2 0 Rnk N-terminus Pkinase PF00069.25 ELR18199.1 - 9.2e-61 205.5 0.0 1.6e-60 204.8 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR18199.1 - 1e-39 136.4 0.0 1.7e-39 135.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase WD40 PF00400.32 ELR18199.1 - 1.2e-34 117.8 22.5 2.5e-05 24.9 0.9 7.9 7 0 0 7 7 7 7 WD domain, G-beta repeat PB1 PF00564.24 ELR18199.1 - 1.4e-09 37.7 0.0 3e-09 36.7 0.0 1.6 1 0 0 1 1 1 1 PB1 domain F-box-like PF12937.7 ELR18199.1 - 3.9e-09 36.3 1.3 8.3e-09 35.2 1.3 1.6 1 0 0 1 1 1 1 F-box-like Nup160 PF11715.8 ELR18199.1 - 1.4e-06 27.3 9.4 0.022 13.4 0.2 4.7 1 1 3 5 5 5 3 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ELR18199.1 - 3.4e-06 27.3 2.5 0.048 14.0 0.0 4.3 2 1 3 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Kinase-like PF14531.6 ELR18199.1 - 7e-06 25.6 0.0 1.2e-05 24.8 0.0 1.3 1 0 0 1 1 1 1 Kinase-like F-box PF00646.33 ELR18199.1 - 0.0006 19.6 0.1 0.0015 18.4 0.1 1.6 1 0 0 1 1 1 1 F-box domain Pkinase_fungal PF17667.1 ELR18199.1 - 0.0044 15.8 0.0 0.0088 14.9 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase FTA2 PF13095.6 ELR18199.1 - 0.068 12.8 0.0 0.12 12.0 0.0 1.3 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 DUF1899 PF08953.11 ELR18200.1 - 1.5e-41 140.1 0.7 3.5e-20 71.7 0.1 2.6 2 0 0 2 2 2 2 Domain of unknown function (DUF1899) WD40_4 PF16300.5 ELR18200.1 - 3.3e-29 100.5 7.3 1.1e-15 57.2 0.5 3.8 3 0 0 3 3 3 3 Type of WD40 repeat WD40 PF00400.32 ELR18200.1 - 1.8e-23 82.4 6.9 0.00092 20.0 0.1 7.5 8 0 0 8 8 8 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ELR18200.1 - 4.4e-10 39.7 0.1 0.023 15.0 0.0 4.9 2 2 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain SOG2 PF10428.9 ELR18200.1 - 0.033 13.4 4.9 0.048 12.9 4.9 1.2 1 0 0 1 1 1 0 RAM signalling pathway protein Chorion_2 PF03964.15 ELR18200.1 - 0.042 14.7 7.1 2.1 9.2 7.6 2.6 2 0 0 2 2 2 0 Chorion family 2 Ge1_WD40 PF16529.5 ELR18200.1 - 0.056 12.4 0.0 5.6 5.8 0.0 2.8 2 1 0 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein IMUP PF15761.5 ELR18200.1 - 0.66 10.7 9.9 1.5 9.5 9.9 1.5 1 0 0 1 1 1 0 Immortalisation up-regulated protein SR-25 PF10500.9 ELR18200.1 - 0.76 9.3 13.5 1.3 8.5 13.5 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Ras PF00071.22 ELR18201.1 - 2.2e-54 183.5 0.1 2.5e-54 183.2 0.1 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR18201.1 - 1e-19 70.9 0.0 1.4e-19 70.5 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR18201.1 - 2.5e-10 40.1 0.0 2.8e-10 39.9 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 ELR18201.1 - 7.3e-05 22.4 0.5 0.00015 21.4 0.3 1.6 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 ELR18201.1 - 0.00052 20.0 0.5 2.6 7.9 0.1 2.9 1 1 1 3 3 3 2 RsgA GTPase FeoB_N PF02421.18 ELR18201.1 - 0.0041 16.7 0.5 0.017 14.7 0.5 2.2 1 1 0 1 1 1 1 Ferrous iron transport protein B MMR_HSR1 PF01926.23 ELR18201.1 - 0.0065 16.5 0.1 0.012 15.7 0.1 1.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase ATP_bind_1 PF03029.17 ELR18201.1 - 0.013 15.3 0.4 0.22 11.2 0.0 2.1 1 1 1 2 2 2 0 Conserved hypothetical ATP binding protein G-alpha PF00503.20 ELR18201.1 - 0.023 13.8 0.0 0.096 11.8 0.0 1.8 1 1 0 1 1 1 0 G-protein alpha subunit NB-ARC PF00931.22 ELR18201.1 - 0.13 11.4 0.1 0.19 10.9 0.1 1.4 1 1 0 1 1 1 0 NB-ARC domain cobW PF02492.19 ELR18201.1 - 0.18 11.4 0.7 0.81 9.2 0.7 2.0 1 1 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain Laminin_II PF06009.12 ELR18202.1 - 0.019 14.9 0.1 0.02 14.9 0.1 1.0 1 0 0 1 1 1 0 Laminin Domain II cwf21 PF08312.12 ELR18202.1 - 0.024 14.8 0.2 0.067 13.4 0.2 1.6 1 1 0 1 1 1 0 cwf21 domain Thymidylat_synt PF00303.19 ELR18203.1 - 2.1e-78 263.2 0.0 2.4e-78 263.0 0.0 1.0 1 0 0 1 1 1 1 Thymidylate synthase WH2 PF02205.20 ELR18204.1 - 0.00026 20.7 0.8 0.00046 19.9 0.8 1.4 1 0 0 1 1 1 1 WH2 motif MMM1 PF10296.9 ELR18205.1 - 7.1e-06 25.3 0.6 0.059 12.4 0.0 3.2 3 1 0 3 3 3 2 Maintenance of mitochondrial morphology protein 1 TALPID3 PF15324.6 ELR18205.1 - 0.24 9.0 12.3 0.081 10.6 9.6 1.5 2 0 0 2 2 2 0 Hedgehog signalling target SR-25 PF10500.9 ELR18205.1 - 1.4 8.5 12.9 1.9 8.0 12.9 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein IMUP PF15761.5 ELR18205.1 - 2 9.1 11.7 3.3 8.5 11.7 1.3 1 0 0 1 1 1 0 Immortalisation up-regulated protein CS PF04969.16 ELR18206.1 - 1.5e-09 38.7 0.2 2e-09 38.4 0.2 1.1 1 0 0 1 1 1 1 CS domain Sporozoite_P67 PF05642.11 ELR18206.1 - 0.35 8.9 7.4 0.46 8.5 7.4 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Forkhead_N PF08430.12 ELR18206.1 - 0.61 10.7 13.5 0.87 10.2 13.5 1.1 1 0 0 1 1 1 0 Forkhead N-terminal region WD40 PF00400.32 ELR18207.1 - 1.5e-19 70.0 7.9 0.0002 22.1 0.0 7.4 8 0 0 8 8 8 5 WD domain, G-beta repeat Zn_ribbon_17 PF17120.5 ELR18207.1 - 3.3e-06 26.6 7.5 8.6e-06 25.3 7.5 1.7 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type zinc_ribbon_16 PF17034.5 ELR18207.1 - 0.0024 18.1 5.4 0.0058 16.9 5.4 1.6 1 0 0 1 1 1 1 Zinc-ribbon like family BBS2_Mid PF14783.6 ELR18207.1 - 0.042 13.9 0.0 1.3 9.1 0.0 2.5 1 1 1 2 2 2 0 Ciliary BBSome complex subunit 2, middle region Pkinase PF00069.25 ELR18208.1 - 8.4e-33 113.8 0.0 4.4e-28 98.4 0.0 3.8 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ELR18208.1 - 8.9e-14 51.4 0.0 3.9e-11 42.7 0.0 3.4 1 1 0 2 2 2 1 Protein tyrosine kinase Myb_DNA-binding PF00249.31 ELR18208.1 - 2.2e-05 24.6 1.4 3.5e-05 23.9 0.3 2.0 2 0 0 2 2 2 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 ELR18208.1 - 0.00029 21.0 0.3 0.00029 21.0 0.3 2.3 2 0 0 2 2 2 1 Myb-like DNA-binding domain CENP-Q PF13094.6 ELR18208.1 - 0.011 16.0 11.7 0.011 16.0 11.7 2.9 2 0 0 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit Ribosomal_L6e PF01159.19 ELR18209.1 - 7.4e-38 129.5 3.8 2.4e-37 127.9 0.5 2.1 2 0 0 2 2 2 1 Ribosomal protein L6e Ribosomal_L6e_N PF03868.15 ELR18209.1 - 2.2e-10 40.6 3.9 2.2e-10 40.6 3.9 2.2 2 0 0 2 2 2 1 Ribosomal protein L6, N-terminal domain PHD20L1_u1 PF16660.5 ELR18209.1 - 0.24 12.1 3.7 0.16 12.7 0.9 2.1 2 1 1 3 3 3 0 PHD finger protein 20-like protein 1 DUF5383 PF17355.2 ELR18209.1 - 1.2 9.5 4.0 0.25 11.7 0.8 1.5 2 0 0 2 2 2 0 Family of unknown function (DUF5383) SNAPc_SNAP43 PF09808.9 ELR18210.1 - 1.8e-33 116.1 1.1 1.8e-33 116.1 1.1 1.8 2 1 1 3 3 3 1 Small nuclear RNA activating complex (SNAPc), subunit SNAP43 FAP PF07174.11 ELR18210.1 - 0.15 11.5 10.1 0.25 10.8 10.1 1.3 1 0 0 1 1 1 0 Fibronectin-attachment protein (FAP) RasGEF PF00617.19 ELR18211.1 - 5.4e-51 173.3 0.4 1.2e-50 172.1 0.2 1.7 2 0 0 2 2 2 1 RasGEF domain RasGEF_N PF00618.20 ELR18211.1 - 6.3e-16 58.5 1.5 1.6e-15 57.2 0.1 2.4 3 0 0 3 3 3 1 RasGEF N-terminal motif Leu_zip PF15294.6 ELR18211.1 - 9.8e-05 22.0 4.2 0.00021 20.9 4.2 1.7 1 0 0 1 1 1 1 Leucine zipper Cep57_CLD_2 PF14197.6 ELR18211.1 - 0.0066 16.5 4.7 0.0066 16.5 4.7 2.6 2 0 0 2 2 2 1 Centrosome localisation domain of PPC89 DASH_Spc19 PF08287.11 ELR18211.1 - 0.024 14.6 5.9 0.056 13.3 5.9 1.6 1 0 0 1 1 1 0 Spc19 PHM7_cyt PF14703.6 ELR18211.1 - 0.031 14.5 0.8 0.12 12.6 0.3 2.3 3 0 0 3 3 3 0 Cytosolic domain of 10TM putative phosphate transporter Shugoshin_N PF07558.11 ELR18211.1 - 0.18 11.7 2.2 4.4 7.3 0.7 2.9 2 1 0 2 2 2 0 Shugoshin N-terminal coiled-coil region Atg14 PF10186.9 ELR18211.1 - 0.42 9.6 6.1 0.77 8.8 6.1 1.4 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Jnk-SapK_ap_N PF09744.9 ELR18211.1 - 0.94 9.7 12.6 2.7 8.2 12.6 1.7 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 HAUS6_N PF14661.6 ELR18211.1 - 2.3 7.7 7.1 6.3 6.3 7.1 1.7 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus UPF0242 PF06785.11 ELR18211.1 - 6.6 6.8 11.2 15 5.7 11.2 1.5 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus APG6_N PF17675.1 ELR18211.1 - 6.9 7.2 15.0 7.4 7.1 12.4 2.5 2 0 0 2 2 2 0 Apg6 coiled-coil region YabA PF06156.13 ELR18211.1 - 9.8 6.9 11.7 5.7 7.6 6.4 2.6 1 1 1 2 2 2 0 Initiation control protein YabA ELL PF10390.9 ELR18212.1 - 2.9e-20 72.9 0.9 2.9e-20 72.9 0.9 2.7 2 1 0 2 2 2 1 RNA polymerase II elongation factor ELL Occludin_ELL PF07303.13 ELR18212.1 - 6.2e-08 33.3 2.9 6.2e-08 33.3 2.9 3.3 3 0 0 3 3 3 1 Occludin homology domain LINES_N PF14694.6 ELR18213.1 - 7.3e-23 81.6 0.0 1.3e-22 80.8 0.0 1.3 1 0 0 1 1 1 1 Lines N-terminus LINES_C PF14695.6 ELR18213.1 - 6e-10 38.4 0.2 1.6e-09 37.0 0.2 1.8 1 0 0 1 1 1 1 Lines C-terminus GGDEF_2 PF17853.1 ELR18213.1 - 0.007 16.6 1.0 1.5 9.1 0.5 3.7 2 1 0 2 2 2 1 GGDEF-like domain TPR_19 PF14559.6 ELR18214.1 - 2.4e-17 63.2 7.0 2.6e-08 34.2 0.7 4.2 3 1 1 4 4 4 4 Tetratricopeptide repeat TPR_17 PF13431.6 ELR18214.1 - 1.6e-13 50.0 3.9 0.0047 17.2 0.1 5.1 5 0 0 5 5 4 4 Tetratricopeptide repeat TPR_14 PF13428.6 ELR18214.1 - 5.2e-11 42.4 7.0 0.0031 18.2 0.1 5.3 4 2 1 5 5 4 3 Tetratricopeptide repeat TPR_2 PF07719.17 ELR18214.1 - 4.3e-08 32.7 10.7 0.11 12.7 0.1 6.6 7 0 0 7 7 6 2 Tetratricopeptide repeat TPR_8 PF13181.6 ELR18214.1 - 1.8e-07 30.8 11.2 0.0071 16.5 0.0 6.4 7 1 0 7 7 7 2 Tetratricopeptide repeat ANAPC3 PF12895.7 ELR18214.1 - 2.5e-07 30.8 2.6 0.00062 19.9 0.2 3.3 3 0 0 3 3 3 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_20 PF14561.6 ELR18214.1 - 1.3e-05 25.4 4.4 0.13 12.7 0.2 3.6 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_6 PF13174.6 ELR18214.1 - 1.5e-05 25.3 4.6 0.13 13.0 0.0 4.7 5 0 0 5 5 4 1 Tetratricopeptide repeat TPR_1 PF00515.28 ELR18214.1 - 4.4e-05 23.1 10.3 0.54 10.2 0.8 6.1 7 0 0 7 7 6 2 Tetratricopeptide repeat TPR_4 PF07721.14 ELR18214.1 - 8.5e-05 22.8 1.3 0.61 10.9 0.7 3.2 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_12 PF13424.6 ELR18214.1 - 0.00011 22.4 13.2 0.02 15.2 0.3 4.7 4 1 0 4 4 4 2 Tetratricopeptide repeat TPR_16 PF13432.6 ELR18214.1 - 0.00013 22.5 5.5 0.002 18.7 0.2 4.1 3 2 2 5 5 5 1 Tetratricopeptide repeat PknG_TPR PF16918.5 ELR18214.1 - 0.00026 19.8 1.9 0.0089 14.8 0.6 2.1 2 0 0 2 2 2 1 Protein kinase G tetratricopeptide repeat Alkyl_sulf_dimr PF14863.6 ELR18214.1 - 0.0018 18.7 1.8 0.0047 17.4 0.3 2.2 2 0 0 2 2 2 1 Alkyl sulfatase dimerisation YfdX PF10938.8 ELR18214.1 - 0.0019 18.2 5.6 0.0051 16.8 0.6 3.2 2 1 1 3 3 3 1 YfdX protein TPR_9 PF13371.6 ELR18214.1 - 0.0021 18.2 2.1 0.13 12.4 0.2 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat POTRA_TamA_1 PF17243.2 ELR18214.1 - 0.0029 17.7 0.3 0.025 14.7 0.0 2.7 2 1 1 3 3 3 1 POTRA domain TamA domain 1 Fis1_TPR_C PF14853.6 ELR18214.1 - 0.0032 17.5 7.9 0.062 13.4 0.3 4.2 5 0 0 5 5 4 1 Fis1 C-terminal tetratricopeptide repeat TPR_15 PF13429.6 ELR18214.1 - 0.0099 15.1 3.9 0.22 10.7 0.2 2.9 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_11 PF13414.6 ELR18214.1 - 0.023 14.4 9.6 0.79 9.5 0.0 5.2 5 2 1 6 6 6 0 TPR repeat TPR_21 PF09976.9 ELR18214.1 - 0.036 13.8 5.5 0.14 11.8 0.1 3.1 2 1 1 3 3 3 0 Tetratricopeptide repeat-like domain HrpB1_HrpK PF09613.10 ELR18214.1 - 0.041 13.5 0.1 1.7 8.3 0.0 2.9 3 0 0 3 3 3 0 Bacterial type III secretion protein (HrpB1_HrpK) ANAPC5 PF12862.7 ELR18214.1 - 0.12 12.5 1.4 3.5 7.8 0.0 3.0 2 1 0 2 2 2 0 Anaphase-promoting complex subunit 5 Serpin PF00079.20 ELR18214.1 - 0.15 11.3 0.0 0.31 10.3 0.0 1.5 1 1 0 1 1 1 0 Serpin (serine protease inhibitor) MIT PF04212.18 ELR18214.1 - 0.24 11.5 9.3 1.2 9.2 1.8 3.7 4 0 0 4 4 3 0 MIT (microtubule interacting and transport) domain ATP-synt_D PF01813.17 ELR18214.1 - 0.27 11.1 4.3 0.1 12.4 0.3 2.4 3 1 0 3 3 3 0 ATP synthase subunit D RRN3 PF05327.11 ELR18214.1 - 4.6 5.7 6.6 7.9 4.9 6.6 1.3 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 DUF4611 PF15387.6 ELR18214.1 - 4.7 7.5 10.7 2.7 8.3 7.2 2.5 3 0 0 3 3 1 0 Domain of unknown function (DUF4611) DUF4378 PF14309.6 ELR18215.1 - 0.033 14.6 0.0 0.17 12.3 0.0 2.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4378) DUF2451 PF10474.9 ELR18216.1 - 1.3e-65 221.5 0.0 7.5e-63 212.4 0.0 2.6 2 0 0 2 2 2 2 Protein of unknown function C-terminus (DUF2451) Vps54_N PF10475.9 ELR18216.1 - 6.2e-55 186.5 0.0 1.4e-54 185.4 0.0 1.6 2 0 0 2 2 2 1 Vacuolar-sorting protein 54, of GARP complex Trns_repr_metal PF02583.17 ELR18216.1 - 0.13 12.6 0.1 0.57 10.6 0.1 2.1 1 0 0 1 1 1 0 Metal-sensitive transcriptional repressor PH PF00169.29 ELR18217.1 - 1.6e-12 47.9 0.1 4.6e-12 46.4 0.1 1.7 2 0 0 2 2 2 1 PH domain SH3_2 PF07653.17 ELR18217.1 - 2.9e-07 30.1 0.0 5.9e-07 29.1 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain PH_11 PF15413.6 ELR18217.1 - 3.4e-07 30.6 0.1 6.2e-07 29.8 0.1 1.5 1 0 0 1 1 1 1 Pleckstrin homology domain PH_8 PF15409.6 ELR18217.1 - 1.5e-06 28.3 0.2 4.2e-05 23.7 0.1 2.5 2 1 0 2 2 2 1 Pleckstrin homology domain SH3_1 PF00018.28 ELR18217.1 - 5.9e-05 22.6 0.0 0.00016 21.2 0.0 1.8 2 0 0 2 2 2 1 SH3 domain SH3_9 PF14604.6 ELR18217.1 - 0.00048 19.9 0.0 0.00076 19.3 0.0 1.3 1 0 0 1 1 1 1 Variant SH3 domain PH_3 PF14593.6 ELR18217.1 - 0.0011 19.1 0.0 0.014 15.5 0.0 2.3 2 1 0 2 2 2 1 PH domain PH_12 PF16457.5 ELR18217.1 - 0.022 15.3 0.3 0.52 10.9 0.3 2.1 1 1 0 1 1 1 0 Pleckstrin homology domain Mcp5_PH PF12814.7 ELR18217.1 - 0.043 13.9 0.0 0.066 13.3 0.0 1.3 1 0 0 1 1 1 0 Meiotic cell cortex C-terminal pleckstrin homology CBS PF00571.28 ELR18218.1 - 1.6e-31 108.5 0.0 5.4e-10 39.6 0.0 4.2 4 0 0 4 4 4 4 CBS domain BiPBP_C PF06832.12 ELR18218.1 - 0.025 14.6 0.0 2.5 8.2 0.0 2.6 2 0 0 2 2 2 0 Penicillin-Binding Protein C-terminus Family Zn_Tnp_IS1 PF03811.13 ELR18219.1 - 0.09 12.5 5.4 0.73 9.6 0.6 2.2 2 0 0 2 2 2 0 InsA N-terminal domain Zn-ribbon_8 PF09723.10 ELR18219.1 - 0.13 12.4 2.8 0.28 11.3 0.1 2.1 2 0 0 2 2 2 0 Zinc ribbon domain Zn_Tnp_IS1595 PF12760.7 ELR18219.1 - 1.9 8.5 7.4 18 5.4 7.4 2.0 1 1 0 1 1 1 0 Transposase zinc-ribbon domain Nudix_N_2 PF14803.6 ELR18220.1 - 0.00096 19.0 3.3 0.089 12.7 0.5 2.6 3 0 0 3 3 3 2 Nudix N-terminal Zn_Tnp_IS1 PF03811.13 ELR18220.1 - 0.012 15.3 2.9 0.14 11.9 0.2 2.2 2 0 0 2 2 2 0 InsA N-terminal domain Zn-ribbon_8 PF09723.10 ELR18220.1 - 0.023 14.8 0.9 0.12 12.5 0.2 2.0 2 0 0 2 2 2 0 Zinc ribbon domain zf-Dof PF02701.15 ELR18220.1 - 0.074 13.2 1.7 2 8.6 0.1 2.2 2 0 0 2 2 2 0 Dof domain, zinc finger Zn_Tnp_IS1595 PF12760.7 ELR18220.1 - 1.2 9.1 6.8 7.7 6.6 6.8 2.0 1 1 0 1 1 1 0 Transposase zinc-ribbon domain F-box-like PF12937.7 ELR18221.1 - 1.2e-11 44.3 0.4 3.4e-11 42.9 0.4 1.8 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ELR18221.1 - 4e-06 26.6 0.3 7.4e-06 25.7 0.3 1.5 1 0 0 1 1 1 1 F-box domain SH2 PF00017.24 ELR18221.1 - 0.00038 20.5 0.0 0.001 19.1 0.0 1.8 2 0 0 2 2 2 1 SH2 domain F-box_4 PF15966.5 ELR18221.1 - 0.00058 19.7 0.0 0.0012 18.7 0.0 1.5 1 0 0 1 1 1 1 F-box Steroid_dh PF02544.16 ELR18222.1 - 4.6e-60 201.9 2.4 8.9e-60 201.0 2.4 1.5 1 0 0 1 1 1 1 3-oxo-5-alpha-steroid 4-dehydrogenase DUF1295 PF06966.12 ELR18222.1 - 3.3e-06 26.8 0.5 6.4e-06 25.9 0.5 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) PEMT PF04191.13 ELR18222.1 - 1.6 9.2 7.3 0.13 12.6 1.4 2.3 3 1 0 3 3 3 0 Phospholipid methyltransferase DUF4131 PF13567.6 ELR18222.1 - 1.9 8.1 7.0 0.35 10.5 0.9 2.6 3 1 1 4 4 4 0 Domain of unknown function (DUF4131) TPR_16 PF13432.6 ELR18223.1 - 3.1e-20 72.5 19.9 0.0069 17.0 0.4 8.4 8 2 2 10 10 9 6 Tetratricopeptide repeat SRP72 PF08492.12 ELR18223.1 - 3.6e-16 59.3 9.2 3.6e-16 59.3 9.2 2.9 2 0 0 2 2 2 1 SRP72 RNA-binding domain SRP_TPR_like PF17004.5 ELR18223.1 - 1.2e-15 57.6 0.2 1.2e-15 57.6 0.2 2.9 3 1 0 3 3 3 1 Putative TPR-like repeat TPR_2 PF07719.17 ELR18223.1 - 1.7e-14 52.7 20.6 0.00089 19.2 0.0 8.7 8 0 0 8 8 8 3 Tetratricopeptide repeat TPR_14 PF13428.6 ELR18223.1 - 1.1e-13 50.7 14.6 0.82 10.7 0.0 9.3 7 3 2 9 9 8 4 Tetratricopeptide repeat TPR_19 PF14559.6 ELR18223.1 - 1.7e-12 47.7 30.2 0.0012 19.3 0.2 8.2 7 1 1 8 8 8 2 Tetratricopeptide repeat TPR_12 PF13424.6 ELR18223.1 - 9.2e-12 45.1 16.2 0.00059 20.1 0.1 7.4 5 3 1 7 7 7 2 Tetratricopeptide repeat ANAPC3 PF12895.7 ELR18223.1 - 1.6e-09 37.9 10.9 8e-05 22.8 1.1 5.2 3 3 2 5 5 5 4 Anaphase-promoting complex, cyclosome, subunit 3 TPR_11 PF13414.6 ELR18223.1 - 9.2e-09 34.9 14.1 0.018 14.7 0.5 5.9 5 0 0 5 5 5 2 TPR repeat TPR_8 PF13181.6 ELR18223.1 - 1.1e-08 34.6 20.4 0.073 13.3 0.0 8.4 9 0 0 9 9 8 3 Tetratricopeptide repeat TPR_1 PF00515.28 ELR18223.1 - 1.9e-08 33.8 20.2 0.00072 19.3 0.0 7.3 8 0 0 8 8 6 2 Tetratricopeptide repeat TPR_6 PF13174.6 ELR18223.1 - 2.6e-08 34.0 21.0 2.6 8.9 0.1 9.7 11 0 0 11 11 10 3 Tetratricopeptide repeat TPR_7 PF13176.6 ELR18223.1 - 9.4e-08 31.6 11.5 0.018 15.0 0.0 7.4 8 1 1 9 9 7 2 Tetratricopeptide repeat TPR_10 PF13374.6 ELR18223.1 - 8e-07 28.7 6.7 0.014 15.3 0.0 6.7 8 0 0 8 8 7 1 Tetratricopeptide repeat TPR_9 PF13371.6 ELR18223.1 - 1.3e-06 28.4 6.3 1.4 9.1 0.0 6.0 5 1 0 5 5 5 1 Tetratricopeptide repeat DUF3808 PF10300.9 ELR18223.1 - 0.00098 18.0 0.7 0.003 16.4 0.3 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF3808) TPR_17 PF13431.6 ELR18223.1 - 0.0035 17.6 8.8 28 5.4 0.0 7.6 9 0 0 9 9 7 0 Tetratricopeptide repeat TPR_21 PF09976.9 ELR18223.1 - 0.0061 16.3 17.2 0.075 12.7 0.0 4.9 3 1 0 4 4 4 1 Tetratricopeptide repeat-like domain TPR_4 PF07721.14 ELR18223.1 - 0.029 15.0 0.4 36 5.4 0.0 4.3 4 0 0 4 4 3 0 Tetratricopeptide repeat Wzy_C_2 PF11846.8 ELR18223.1 - 0.049 13.6 0.7 3.1 7.7 0.0 3.4 3 0 0 3 3 3 0 Virulence factor membrane-bound polymerase, C-terminal DUF4810 PF16068.5 ELR18223.1 - 0.05 14.1 3.0 70 4.1 0.0 4.6 4 2 1 5 5 4 0 Domain of unknown function (DUF4810) SHNi-TPR PF10516.9 ELR18223.1 - 0.13 11.8 0.9 0.69 9.4 0.2 2.6 2 0 0 2 2 2 0 SHNi-TPR NRDE-2 PF08424.10 ELR18223.1 - 0.15 11.2 1.9 1.4 7.9 0.1 2.5 2 1 0 2 2 2 0 NRDE-2, necessary for RNA interference TPR_3 PF07720.12 ELR18223.1 - 0.17 11.9 11.5 1.4 9.0 0.3 4.5 4 0 0 4 4 4 0 Tetratricopeptide repeat Vps39_1 PF10366.9 ELR18223.1 - 3.9 7.8 8.5 5.5 7.3 0.1 3.5 2 2 2 4 4 4 0 Vacuolar sorting protein 39 domain 1 TRAPPC10 PF12584.8 ELR18224.1 - 1.7e-08 34.3 0.0 4.6e-08 32.9 0.0 1.7 1 0 0 1 1 1 1 Trafficking protein particle complex subunit 10, TRAPPC10 Foie-gras_1 PF11817.8 ELR18224.1 - 1.9e-06 27.7 1.8 4.9e-06 26.3 1.8 1.7 1 1 0 1 1 1 1 Foie gras liver health family 1 Gryzun-like PF12742.7 ELR18224.1 - 0.02 14.9 0.0 0.042 13.9 0.0 1.5 1 0 0 1 1 1 0 Gryzun, putative Golgi trafficking Transglut_core3 PF13471.6 ELR18224.1 - 0.11 12.4 0.4 0.49 10.3 0.4 2.1 1 0 0 1 1 1 0 Transglutaminase-like superfamily DUF3950 PF13132.6 ELR18224.1 - 1 9.2 3.4 0.51 10.1 0.2 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF3950) TSP_3 PF02412.18 ELR18225.1 - 0.0071 16.0 9.4 0.0071 16.0 9.4 4.1 4 1 1 5 5 5 1 Thrombospondin type 3 repeat EF-hand_1 PF00036.32 ELR18225.1 - 0.011 15.2 3.5 0.56 9.9 0.3 2.4 2 0 0 2 2 2 0 EF hand EF-hand_7 PF13499.6 ELR18225.1 - 1.1 9.7 3.0 11 6.5 0.1 2.3 2 0 0 2 2 2 0 EF-hand domain pair EF-hand_5 PF13202.6 ELR18225.1 - 1.7 8.2 8.1 3.9 7.2 1.4 2.3 2 0 0 2 2 2 0 EF hand UQ_con PF00179.26 ELR18226.1 - 3.8e-37 127.1 0.0 5.9e-37 126.4 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UEV PF05743.13 ELR18226.1 - 0.09 12.6 0.0 0.16 11.8 0.0 1.4 1 0 0 1 1 1 0 UEV domain Pkinase PF00069.25 ELR18227.1 - 4.3e-47 160.7 0.0 3.4e-35 121.7 0.0 2.1 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ELR18227.1 - 7.7e-26 90.9 0.0 4.2e-19 68.9 0.0 2.1 1 1 1 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 ELR18227.1 - 1.1e-09 38.0 0.0 4.8e-09 35.9 0.0 1.8 2 0 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 ELR18227.1 - 0.00051 18.9 0.0 0.00096 18.0 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 ELR18227.1 - 0.019 14.9 0.0 0.033 14.1 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family FTA2 PF13095.6 ELR18227.1 - 0.21 11.2 0.0 0.4 10.3 0.0 1.4 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 A_thal_3526 PF09713.10 ELR18228.1 - 4.4e-19 68.5 0.1 7.2e-19 67.8 0.1 1.3 1 0 0 1 1 1 1 Plant protein 1589 of unknown function (A_thal_3526) QLQ PF08880.11 ELR18228.1 - 0.38 10.5 2.2 0.4 10.5 0.2 2.1 2 0 0 2 2 2 0 QLQ BUD22 PF09073.10 ELR18228.1 - 2.9 7.2 10.8 4.6 6.5 10.8 1.2 1 0 0 1 1 1 0 BUD22 Ras PF00071.22 ELR18229.1 - 3.5e-37 127.5 0.2 2.2e-35 121.7 0.2 2.0 1 1 0 1 1 1 1 Ras family Roc PF08477.13 ELR18229.1 - 3.6e-22 78.8 0.3 8e-21 74.5 0.3 2.1 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR18229.1 - 7.3e-08 32.1 0.0 1.6e-07 30.9 0.0 1.5 1 1 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 ELR18229.1 - 4.4e-06 26.2 0.0 7.6e-06 25.4 0.0 1.3 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.10 ELR18229.1 - 0.0005 19.6 0.0 0.00078 18.9 0.0 1.3 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 ELR18229.1 - 0.011 15.8 0.0 0.016 15.3 0.0 1.3 1 0 0 1 1 1 0 50S ribosome-binding GTPase Septin PF00735.18 ELR18229.1 - 0.022 14.1 0.0 0.027 13.8 0.0 1.1 1 0 0 1 1 1 0 Septin TniB PF05621.11 ELR18229.1 - 0.023 14.1 0.0 0.033 13.6 0.0 1.4 1 1 0 1 1 1 0 Bacterial TniB protein DUF2791 PF10923.8 ELR18229.1 - 0.031 13.1 0.0 0.082 11.7 0.0 1.6 2 0 0 2 2 2 0 P-loop Domain of unknown function (DUF2791) AAA_22 PF13401.6 ELR18229.1 - 0.071 13.4 0.1 0.2 11.9 0.1 1.7 1 1 0 1 1 1 0 AAA domain AAA_16 PF13191.6 ELR18229.1 - 0.08 13.3 0.0 0.18 12.1 0.0 1.5 1 1 0 1 1 1 0 AAA ATPase domain AAA_28 PF13521.6 ELR18229.1 - 0.1 12.8 0.8 0.55 10.5 0.8 2.3 1 1 0 1 1 1 0 AAA domain PduV-EutP PF10662.9 ELR18229.1 - 0.11 12.3 0.0 0.49 10.1 0.0 2.0 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation ABC_tran PF00005.27 ELR18229.1 - 0.12 12.9 0.0 0.21 12.1 0.0 1.7 1 1 0 1 1 1 0 ABC transporter DUF1971 PF09313.11 ELR18229.1 - 0.12 12.3 0.1 0.21 11.6 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1971) AAA_7 PF12775.7 ELR18229.1 - 0.13 11.8 0.0 0.23 11.0 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region His_Phos_1 PF00300.22 ELR18230.1 - 2.4e-28 99.2 0.3 3.9e-28 98.5 0.3 1.3 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) DUF3431 PF11913.8 ELR18230.1 - 0.0046 16.8 0.2 0.0091 15.8 0.2 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3431) Cyclin_N PF00134.23 ELR18231.1 - 1.5e-14 53.9 0.9 1e-12 47.9 0.2 2.2 2 0 0 2 2 2 2 Cyclin, N-terminal domain TFIIB PF00382.19 ELR18231.1 - 0.04 14.0 0.3 0.13 12.4 0.2 1.9 2 0 0 2 2 2 0 Transcription factor TFIIB repeat FAM27 PF15832.5 ELR18231.1 - 0.053 14.1 7.6 0.1 13.2 7.6 1.5 1 0 0 1 1 1 0 FAM27 D and E protein family DUF3915 PF13054.6 ELR18231.1 - 0.53 10.3 5.9 0.88 9.6 5.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) Atrophin-1 PF03154.15 ELR18231.1 - 0.58 8.4 10.4 0.96 7.7 10.4 1.3 1 0 0 1 1 1 0 Atrophin-1 family RRM_1 PF00076.22 ELR18232.1 - 7.2e-11 41.7 0.7 7.5e-09 35.3 0.0 2.9 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SET_assoc PF11767.8 ELR18232.1 - 0.094 12.4 0.1 0.46 10.2 0.0 2.0 2 0 0 2 2 2 0 Histone lysine methyltransferase SET associated Yippee-Mis18 PF03226.14 ELR18233.1 - 0.015 15.5 0.1 0.032 14.5 0.1 1.5 1 0 0 1 1 1 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly YliH PF10799.8 ELR18233.1 - 0.018 15.0 0.8 0.018 15.0 0.8 1.7 2 0 0 2 2 2 0 Biofilm formation protein (YliH/bssR) LIM PF00412.22 ELR18233.1 - 0.028 14.7 0.0 0.053 13.8 0.0 1.4 1 0 0 1 1 1 0 LIM domain Presenilin PF01080.17 ELR18233.1 - 0.22 10.3 4.7 0.31 9.8 4.7 1.2 1 0 0 1 1 1 0 Presenilin DUF883 PF05957.13 ELR18233.1 - 0.27 11.8 8.1 0.071 13.7 4.0 2.1 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF883) KCT2 PF17818.1 ELR18233.1 - 0.31 11.2 3.3 0.29 11.2 2.3 1.5 1 1 0 1 1 1 0 Keratinocyte-associated gene product CDC45 PF02724.14 ELR18233.1 - 0.32 9.3 7.3 0.33 9.2 7.3 1.1 1 0 0 1 1 1 0 CDC45-like protein Tfb4 PF03850.14 ELR18233.1 - 5.1 6.5 7.8 6.9 6.1 6.7 1.8 1 1 1 2 2 2 0 Transcription factor Tfb4 XRN_M PF17846.1 ELR18233.1 - 8.3 5.2 7.7 10 4.9 7.2 1.4 1 1 0 1 1 1 0 Xrn1 helical domain Methyltransf_2 PF00891.18 ELR18234.1 - 4.1e-34 117.7 0.0 5.9e-34 117.2 0.0 1.3 1 0 0 1 1 1 1 O-methyltransferase domain Methyltransf_31 PF13847.6 ELR18234.1 - 5.7e-07 29.4 0.0 8.3e-07 28.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ELR18234.1 - 0.00023 21.8 0.0 0.00039 21.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ELR18234.1 - 0.0003 21.5 0.0 0.00061 20.4 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Dimerisation PF08100.11 ELR18234.1 - 0.0012 18.8 0.0 0.0027 17.7 0.0 1.7 1 0 0 1 1 1 1 Dimerisation domain Methyltransf_23 PF13489.6 ELR18234.1 - 0.0078 16.1 0.0 0.014 15.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Dimerisation2 PF16864.5 ELR18234.1 - 0.078 13.0 0.0 0.13 12.2 0.0 1.3 1 0 0 1 1 1 0 Dimerisation domain Methyltransf_11 PF08241.12 ELR18234.1 - 0.08 13.6 0.0 0.15 12.7 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_2 PF00891.18 ELR18235.1 - 3.7e-09 36.2 0.0 4.2e-09 36.0 0.0 1.1 1 0 0 1 1 1 1 O-methyltransferase domain DREV PF05219.12 ELR18235.1 - 0.056 12.5 0.0 0.056 12.5 0.0 1.0 1 0 0 1 1 1 0 DREV methyltransferase Methyltransf_2 PF00891.18 ELR18237.1 - 1.1e-42 145.7 0.0 1.5e-42 145.3 0.0 1.2 1 0 0 1 1 1 1 O-methyltransferase domain Methyltransf_12 PF08242.12 ELR18237.1 - 1.4e-06 28.9 0.0 2.5e-06 28.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ELR18237.1 - 6.7e-06 26.0 0.0 9.9e-06 25.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ELR18237.1 - 2.7e-05 24.8 0.0 6e-05 23.7 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 ELR18237.1 - 6.2e-05 22.9 0.0 9e-05 22.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain DREV PF05219.12 ELR18237.1 - 0.00067 18.8 0.0 0.00099 18.3 0.0 1.2 1 0 0 1 1 1 1 DREV methyltransferase Methyltransf_11 PF08241.12 ELR18237.1 - 0.018 15.7 0.0 0.04 14.6 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain MTS PF05175.14 ELR18237.1 - 0.09 12.3 0.0 0.23 11.0 0.0 1.5 1 1 0 1 1 1 0 Methyltransferase small domain DUF3725 PF12523.8 ELR18237.1 - 0.17 12.2 0.0 3.1 8.2 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3725) DEAD PF00270.29 ELR18238.1 - 5.4e-40 137.0 0.0 9.1e-40 136.3 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ELR18238.1 - 1.3e-20 73.8 0.0 5.3e-20 71.8 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 ELR18238.1 - 1.3e-15 57.4 0.2 3e-15 56.2 0.2 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) AAA_22 PF13401.6 ELR18238.1 - 3.5e-05 24.1 0.0 9.7e-05 22.7 0.0 1.8 1 0 0 1 1 1 1 AAA domain K_channel_TID PF07941.11 ELR18238.1 - 0.43 11.1 4.6 1 9.9 4.6 1.6 1 0 0 1 1 1 0 Potassium channel Kv1.4 tandem inactivation domain BTB PF00651.31 ELR18239.1 - 1.2e-16 60.9 0.6 9.7e-16 58.0 0.1 2.1 1 1 1 2 2 2 1 BTB/POZ domain UBA_4 PF14555.6 ELR18239.1 - 5.8e-13 48.4 0.3 1.3e-12 47.3 0.3 1.6 1 0 0 1 1 1 1 UBA-like domain BACK PF07707.15 ELR18239.1 - 1.8e-12 47.2 0.0 5.9e-12 45.6 0.0 1.9 1 1 1 2 2 2 1 BTB And C-terminal Kelch SPRY PF00622.28 ELR18239.1 - 2.9e-08 33.8 0.1 4.7e-08 33.2 0.1 1.4 1 0 0 1 1 1 1 SPRY domain Neuralized PF07177.12 ELR18239.1 - 0.0083 16.1 0.0 0.02 14.9 0.0 1.7 1 1 0 1 1 1 1 Neuralized TAP_C PF03943.13 ELR18239.1 - 0.059 13.0 0.0 0.18 11.5 0.0 1.9 1 0 0 1 1 1 0 TAP C-terminal domain LZ3wCH PF18517.1 ELR18240.1 - 9.2e-21 73.7 0.5 9.2e-21 73.7 0.5 2.4 2 0 0 2 2 2 1 Leucine zipper with capping helix domain Mnd1 PF03962.15 ELR18240.1 - 2.1e-20 72.8 0.1 4.3e-20 71.8 0.1 1.6 1 0 0 1 1 1 1 Mnd1 HTH domain Remorin_N PF03766.13 ELR18240.1 - 0.025 14.6 0.5 0.067 13.3 0.5 1.7 1 0 0 1 1 1 0 Remorin, N-terminal region MIF4G_like_2 PF09090.11 ELR18240.1 - 0.033 13.7 5.4 0.047 13.2 2.0 2.0 2 0 0 2 2 2 0 MIF4G like DUF4407 PF14362.6 ELR18240.1 - 0.073 12.4 1.9 0.082 12.2 1.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DivIC PF04977.15 ELR18240.1 - 0.098 12.4 16.6 0.45 10.3 2.1 3.3 2 1 1 3 3 3 0 Septum formation initiator Allexi_40kDa PF05549.11 ELR18240.1 - 0.11 12.0 2.1 0.15 11.5 1.7 1.5 1 1 0 1 1 1 0 Allexivirus 40kDa protein UPF0242 PF06785.11 ELR18240.1 - 0.31 11.1 10.8 0.58 10.2 10.8 1.6 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus TMF_TATA_bd PF12325.8 ELR18240.1 - 7.1 6.9 14.7 0.64 10.2 7.9 2.1 2 0 0 2 2 2 0 TATA element modulatory factor 1 TATA binding Glyco_hydro_16 PF00722.21 ELR18241.1 - 5.4e-09 35.8 0.1 1.3e-08 34.6 0.1 1.6 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 Glyco_hydro_42 PF02449.15 ELR18241.1 - 1.5e-06 27.8 0.0 2.3e-06 27.2 0.0 1.2 1 0 0 1 1 1 1 Beta-galactosidase EGF_2 PF07974.13 ELR18241.1 - 0.0007 19.9 20.0 0.0016 18.7 20.0 1.7 1 0 0 1 1 1 1 EGF-like domain EGF_Tenascin PF18720.1 ELR18241.1 - 0.28 11.3 11.4 0.78 9.9 11.4 1.8 1 0 0 1 1 1 0 Tenascin EGF domain AAA_2 PF07724.14 ELR18242.1 - 2.3e-53 180.8 0.0 1.9e-51 174.6 0.0 2.4 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_lid_9 PF17871.1 ELR18242.1 - 4.4e-36 123.0 1.0 4.4e-36 123.0 1.0 2.3 1 1 1 2 2 2 1 AAA lid domain ClpB_D2-small PF10431.9 ELR18242.1 - 1.1e-28 99.1 0.1 4.2e-28 97.2 0.1 2.1 1 0 0 1 1 1 1 C-terminal, D2-small domain, of ClpB protein AAA PF00004.29 ELR18242.1 - 2.6e-23 82.9 0.0 3.8e-13 50.0 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 ELR18242.1 - 1.4e-16 60.7 0.0 1.1e-11 44.9 0.0 3.2 3 0 0 3 3 3 2 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 ELR18242.1 - 6.7e-10 39.6 6.5 1.9e-05 25.1 0.0 4.3 3 2 2 5 5 5 2 AAA ATPase domain Sigma54_activat PF00158.26 ELR18242.1 - 1e-06 28.6 0.0 0.00031 20.5 0.0 2.7 2 0 0 2 2 2 1 Sigma-54 interaction domain AAA_22 PF13401.6 ELR18242.1 - 1.5e-06 28.5 5.3 0.15 12.3 0.1 5.0 3 2 0 3 3 3 2 AAA domain TniB PF05621.11 ELR18242.1 - 1.9e-06 27.5 0.0 0.0074 15.7 0.0 3.5 2 1 0 2 2 2 1 Bacterial TniB protein AAA_7 PF12775.7 ELR18242.1 - 1.1e-05 25.1 0.0 0.021 14.4 0.0 2.5 2 0 0 2 2 2 2 P-loop containing dynein motor region ATPase_2 PF01637.18 ELR18242.1 - 7.2e-05 22.8 3.2 2.3 8.1 0.1 4.1 4 1 0 4 4 4 1 ATPase domain predominantly from Archaea Roc PF08477.13 ELR18242.1 - 0.00012 22.3 0.0 0.41 10.9 0.0 2.5 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase AAA_24 PF13479.6 ELR18242.1 - 0.00015 21.6 0.0 0.48 10.1 0.0 2.6 2 0 0 2 2 2 2 AAA domain RNA_helicase PF00910.22 ELR18242.1 - 0.00019 21.8 0.1 0.62 10.5 0.0 3.0 3 0 0 3 3 3 1 RNA helicase IstB_IS21 PF01695.17 ELR18242.1 - 0.0002 21.1 0.1 0.29 10.8 0.0 2.8 3 0 0 3 3 2 2 IstB-like ATP binding protein Mg_chelatase PF01078.21 ELR18242.1 - 0.00028 20.4 0.1 0.7 9.2 0.0 3.0 3 0 0 3 3 3 2 Magnesium chelatase, subunit ChlI AAA_18 PF13238.6 ELR18242.1 - 0.00039 21.0 2.4 0.12 12.9 0.0 3.1 3 1 0 3 3 2 1 AAA domain AAA_14 PF13173.6 ELR18242.1 - 0.00058 19.9 0.0 0.83 9.7 0.0 3.0 3 0 0 3 3 2 1 AAA domain AAA_28 PF13521.6 ELR18242.1 - 0.00064 20.0 0.2 7.2 6.8 0.0 3.9 3 1 0 3 3 3 0 AAA domain AAA_25 PF13481.6 ELR18242.1 - 0.00099 18.7 0.0 0.19 11.3 0.0 2.7 2 0 0 2 2 2 1 AAA domain RuvB_N PF05496.12 ELR18242.1 - 0.001 18.8 0.5 14 5.4 0.0 3.7 4 0 0 4 4 3 0 Holliday junction DNA helicase RuvB P-loop domain RsgA_GTPase PF03193.16 ELR18242.1 - 0.0011 18.9 0.2 2.4 8.0 0.0 2.9 3 0 0 3 3 2 2 RsgA GTPase NACHT PF05729.12 ELR18242.1 - 0.0013 18.7 0.0 0.23 11.3 0.0 2.5 2 0 0 2 2 2 1 NACHT domain TsaE PF02367.17 ELR18242.1 - 0.0013 18.7 0.0 2 8.4 0.0 2.5 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_23 PF13476.6 ELR18242.1 - 0.0086 16.6 9.3 14 6.1 0.0 3.4 3 0 0 3 3 3 0 AAA domain AAA_33 PF13671.6 ELR18242.1 - 0.0088 16.2 0.0 2.4 8.3 0.0 2.9 2 0 0 2 2 2 1 AAA domain DNA_pol3_delta2 PF13177.6 ELR18242.1 - 0.015 15.1 0.0 7.9 6.2 0.0 2.6 2 0 0 2 2 2 0 DNA polymerase III, delta subunit AAA_3 PF07726.11 ELR18242.1 - 0.015 15.2 0.1 5.6 6.8 0.0 3.1 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_19 PF13245.6 ELR18242.1 - 0.026 14.8 0.2 4.3 7.7 0.2 3.1 3 1 1 4 4 2 0 AAA domain AAA_30 PF13604.6 ELR18242.1 - 0.027 14.2 0.0 4.3 7.0 0.1 2.8 2 0 0 2 2 2 0 AAA domain DUF815 PF05673.13 ELR18242.1 - 0.03 13.5 0.1 1 8.4 0.1 2.9 2 1 0 2 2 2 0 Protein of unknown function (DUF815) NTPase_1 PF03266.15 ELR18242.1 - 0.034 14.0 0.1 13 5.7 0.0 2.7 2 0 0 2 2 2 0 NTPase AAA_29 PF13555.6 ELR18242.1 - 0.039 13.7 0.0 7.8 6.3 0.0 2.5 2 0 0 2 2 2 0 P-loop containing region of AAA domain SRP54 PF00448.22 ELR18242.1 - 0.043 13.4 0.0 1.1 8.8 0.0 2.6 3 0 0 3 3 2 0 SRP54-type protein, GTPase domain ATP_bind_1 PF03029.17 ELR18242.1 - 0.07 12.9 0.0 0.95 9.2 0.0 2.2 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein MCM PF00493.23 ELR18242.1 - 0.075 12.1 0.1 2.3 7.3 0.0 2.6 2 1 0 2 2 2 0 MCM P-loop domain ABC_tran PF00005.27 ELR18242.1 - 0.086 13.4 1.9 5.8 7.4 0.0 3.0 3 0 0 3 3 2 0 ABC transporter PduV-EutP PF10662.9 ELR18242.1 - 0.15 11.8 0.0 2.1 8.1 0.0 2.3 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation DUF2959 PF11172.8 ELR18242.1 - 0.44 10.7 3.9 1.2 9.3 3.9 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2959) DUF4407 PF14362.6 ELR18242.1 - 0.48 9.7 4.9 0.76 9.1 4.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Cnn_1N PF07989.11 ELR18242.1 - 1.8 8.8 11.9 0.28 11.4 1.1 3.4 2 1 1 3 3 3 0 Centrosomin N-terminal motif 1 ADIP PF11559.8 ELR18242.1 - 4.5 7.3 13.7 9.2 6.3 13.7 1.4 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding DUF3450 PF11932.8 ELR18242.1 - 5.8 6.1 10.3 4.8 6.4 4.8 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) FlxA PF14282.6 ELR18242.1 - 7.9 6.5 9.6 3.5 7.7 3.7 2.2 1 1 1 2 2 2 0 FlxA-like protein APG6_N PF17675.1 ELR18242.1 - 8.8 6.9 14.2 21 5.7 14.2 1.6 1 0 0 1 1 1 0 Apg6 coiled-coil region Arf PF00025.21 ELR18243.1 - 9.3e-41 139.2 0.0 1e-40 139.1 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family G-alpha PF00503.20 ELR18243.1 - 2.1e-06 27.1 0.0 2.4e-06 27.0 0.0 1.1 1 0 0 1 1 1 1 G-protein alpha subunit Roc PF08477.13 ELR18243.1 - 6e-06 26.5 0.0 7.9e-06 26.1 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 ELR18243.1 - 0.001 18.7 0.0 0.0012 18.5 0.0 1.1 1 0 0 1 1 1 1 Ras family SRPRB PF09439.10 ELR18243.1 - 0.0048 16.4 0.0 0.0049 16.3 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 ELR18243.1 - 0.0071 15.7 0.0 0.0071 15.7 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 ELR18243.1 - 0.033 14.3 0.0 0.05 13.7 0.0 1.2 1 0 0 1 1 1 0 50S ribosome-binding GTPase eIF3_N PF09440.10 ELR18244.1 - 2.5e-38 131.5 3.9 3.1e-38 131.2 1.3 2.4 2 1 0 2 2 2 1 eIF3 subunit 6 N terminal domain PCI PF01399.27 ELR18244.1 - 6.5e-20 71.6 0.1 1.9e-19 70.1 0.1 1.9 1 0 0 1 1 1 1 PCI domain DUF1682 PF07946.14 ELR18245.1 - 1.7e-68 231.3 8.0 4.6e-68 229.8 8.0 1.6 1 1 0 1 1 1 1 Protein of unknown function (DUF1682) RNA_pol_Rpc4 PF05132.14 ELR18245.1 - 0.0013 19.2 9.2 0.0027 18.1 3.3 2.2 2 0 0 2 2 2 2 RNA polymerase III RPC4 rRNA_processing PF08524.11 ELR18245.1 - 2.4 8.2 18.8 3.9 7.5 18.8 1.2 1 0 0 1 1 1 0 rRNA processing ORMDL PF04061.14 ELR18246.1 - 2.6e-52 176.3 4.7 2.9e-52 176.1 4.7 1.0 1 0 0 1 1 1 1 ORMDL family CsbD PF05532.12 ELR18248.1 - 0.002 18.0 1.2 0.0031 17.4 1.2 1.2 1 0 0 1 1 1 1 CsbD-like Lactamase_B_6 PF16661.5 ELR18249.1 - 2.1e-41 141.5 0.3 5.8e-27 94.4 0.0 2.4 1 1 1 2 2 2 2 Metallo-beta-lactamase superfamily domain CPSF100_C PF13299.6 ELR18249.1 - 7.2e-38 130.4 1.7 3.2e-19 69.7 0.0 4.1 2 1 2 4 4 4 3 Cleavage and polyadenylation factor 2 C-terminal Beta-Casp PF10996.8 ELR18249.1 - 8.6e-18 64.6 0.0 2.3e-17 63.2 0.0 1.7 1 0 0 1 1 1 1 Beta-Casp domain RMMBL PF07521.12 ELR18249.1 - 2.3e-07 30.6 0.0 5.4e-07 29.4 0.0 1.7 1 0 0 1 1 1 1 Zn-dependent metallo-hydrolase RNA specificity domain Lactamase_B PF00753.27 ELR18249.1 - 0.00017 21.6 0.0 0.00061 19.9 0.0 1.9 2 0 0 2 2 2 1 Metallo-beta-lactamase superfamily DFRP_C PF16543.5 ELR18249.1 - 0.0021 18.5 2.6 1.2 9.6 2.3 4.0 4 0 0 4 4 4 1 DRG Family Regulatory Proteins, Tma46 Lactamase_B_2 PF12706.7 ELR18249.1 - 0.0021 17.6 0.3 0.0075 15.8 0.3 2.0 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Cnn_1N PF07989.11 ELR18250.1 - 0.00015 21.8 3.1 0.00022 21.3 3.0 1.4 1 1 0 1 1 1 1 Centrosomin N-terminal motif 1 bZIP_1 PF00170.21 ELR18250.1 - 0.00031 20.8 1.7 0.00043 20.3 1.7 1.3 1 0 0 1 1 1 1 bZIP transcription factor DivIC PF04977.15 ELR18250.1 - 0.0009 19.0 3.4 0.0015 18.2 3.4 1.4 1 0 0 1 1 1 1 Septum formation initiator HALZ PF02183.18 ELR18250.1 - 0.0017 18.5 1.7 0.0034 17.6 1.7 1.6 1 0 0 1 1 1 1 Homeobox associated leucine zipper DUF2205 PF10224.9 ELR18250.1 - 0.0038 17.2 0.3 0.0052 16.8 0.3 1.3 1 0 0 1 1 1 1 Short coiled-coil protein ZapB PF06005.12 ELR18250.1 - 0.009 16.4 5.5 0.014 15.9 5.3 1.5 1 1 0 1 1 1 1 Cell division protein ZapB bZIP_2 PF07716.15 ELR18250.1 - 0.0099 15.9 2.1 0.016 15.3 2.1 1.4 1 0 0 1 1 1 1 Basic region leucine zipper GED PF02212.18 ELR18250.1 - 0.013 15.6 1.0 0.02 15.0 1.0 1.3 1 0 0 1 1 1 0 Dynamin GTPase effector domain Shugoshin_N PF07558.11 ELR18250.1 - 0.014 15.3 0.6 0.024 14.5 0.6 1.5 1 0 0 1 1 1 0 Shugoshin N-terminal coiled-coil region CENP-H PF05837.12 ELR18250.1 - 0.018 15.4 1.3 0.023 15.1 1.3 1.2 1 0 0 1 1 1 0 Centromere protein H (CENP-H) FlaC_arch PF05377.11 ELR18250.1 - 0.021 15.2 1.6 0.049 14.0 0.3 2.0 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) YabA PF06156.13 ELR18250.1 - 0.075 13.7 2.6 0.13 12.9 2.5 1.6 1 1 0 1 1 1 0 Initiation control protein YabA tRNA-synt_2c PF01411.19 ELR18251.1 - 7.6e-150 500.0 0.0 1e-149 499.6 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (A) tRNA_SAD PF07973.14 ELR18251.1 - 1.4e-14 53.9 0.1 3.1e-14 52.8 0.1 1.7 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain DHHA1 PF02272.19 ELR18251.1 - 1.9e-11 44.5 0.6 5e-11 43.2 0.3 1.9 2 0 0 2 2 2 1 DHHA1 domain TMF_DNA_bd PF12329.8 ELR18251.1 - 0.045 13.8 0.2 0.1 12.6 0.2 1.6 1 0 0 1 1 1 0 TATA element modulatory factor 1 DNA binding SMC_N PF02463.19 ELR18252.1 - 1.2e-66 224.3 41.6 3.5e-66 222.8 41.6 2.0 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 ELR18252.1 - 2.8e-23 82.5 2.3 5.9e-22 78.2 0.0 3.3 3 0 0 3 3 3 1 SMC proteins Flexible Hinge Domain AAA_15 PF13175.6 ELR18252.1 - 9.4e-16 58.5 0.1 9.4e-16 58.5 0.1 3.9 2 2 1 3 3 3 1 AAA ATPase domain AAA_21 PF13304.6 ELR18252.1 - 6.6e-13 49.1 5.0 2.2e-07 31.0 0.1 3.0 2 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 ELR18252.1 - 1.7e-05 24.5 0.0 3.7e-05 23.4 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_22 PF13401.6 ELR18252.1 - 0.55 10.5 6.9 5.6 7.2 0.0 4.8 4 1 0 4 4 4 0 AAA domain WD40 PF00400.32 ELR18253.1 - 1.4e-154 497.3 83.0 4.3e-10 40.0 0.2 20.9 21 0 0 21 21 20 20 WD domain, G-beta repeat TROVE PF05731.11 ELR18253.1 - 1.3e-89 301.3 1.1 2.1e-58 198.5 0.2 2.5 1 1 1 2 2 2 2 TROVE domain ANAPC4_WD40 PF12894.7 ELR18253.1 - 8.9e-49 163.7 8.8 0.0019 18.5 0.0 15.7 1 1 14 16 16 16 11 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ELR18253.1 - 2.5e-27 95.7 17.4 0.16 10.9 0.0 15.9 3 3 13 17 17 17 8 WD40 region of Ge1, enhancer of mRNA-decapping protein DUF4062 PF13271.6 ELR18253.1 - 2.8e-19 69.2 0.0 8e-19 67.8 0.0 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF4062) eIF2A PF08662.11 ELR18253.1 - 4e-16 59.5 0.4 0.0015 18.4 0.0 8.0 2 2 6 9 9 9 4 Eukaryotic translation initiation factor eIF2A APAF1_C PF17908.1 ELR18253.1 - 2.1e-11 44.0 0.0 4.4e-11 42.9 0.0 1.4 1 0 0 1 1 1 1 APAF-1 helical domain PD40 PF07676.12 ELR18253.1 - 1.4e-10 40.8 6.7 19 5.3 0.0 11.0 12 0 0 12 12 12 0 WD40-like Beta Propeller Repeat NACHT PF05729.12 ELR18253.1 - 1.7e-10 41.1 0.0 4.4e-10 39.7 0.0 1.8 1 0 0 1 1 1 1 NACHT domain Cytochrom_D1 PF02239.16 ELR18253.1 - 5.3e-10 38.4 4.0 0.024 13.2 0.0 5.9 3 2 2 6 6 6 4 Cytochrome D1 heme domain AAA_16 PF13191.6 ELR18253.1 - 1.6e-09 38.4 0.1 1.6e-09 38.4 0.1 2.4 2 0 0 2 2 1 1 AAA ATPase domain VID27 PF08553.10 ELR18253.1 - 1.9e-07 30.5 0.6 0.026 13.6 0.0 5.3 3 2 2 5 5 5 1 VID27 C-terminal WD40-like domain AAA_22 PF13401.6 ELR18253.1 - 6.6e-07 29.7 0.0 4e-06 27.1 0.0 2.4 2 1 1 3 3 2 1 AAA domain Frtz PF11768.8 ELR18253.1 - 2.9e-06 25.9 0.2 0.57 8.4 0.0 5.6 5 2 2 7 7 7 2 WD repeat-containing and planar cell polarity effector protein Fritz ATPase_2 PF01637.18 ELR18253.1 - 0.001 19.0 0.0 0.0037 17.2 0.0 2.0 2 0 0 2 2 1 1 ATPase domain predominantly from Archaea Nup160 PF11715.8 ELR18253.1 - 0.0014 17.4 26.6 3.2 6.3 0.2 10.4 5 5 6 13 13 13 1 Nucleoporin Nup120/160 WD40_like PF17005.5 ELR18253.1 - 0.0023 17.3 0.0 8.8 5.6 0.0 4.2 5 1 1 6 6 6 0 WD40-like domain AAA_5 PF07728.14 ELR18253.1 - 0.0076 16.3 0.0 0.039 13.9 0.0 2.2 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_30 PF13604.6 ELR18253.1 - 0.022 14.5 0.2 0.2 11.3 0.0 2.3 2 0 0 2 2 2 0 AAA domain DPPIV_N PF00930.21 ELR18253.1 - 0.077 11.7 3.8 24 3.5 0.0 4.9 5 0 0 5 5 5 0 Dipeptidyl peptidase IV (DPP IV) N-terminal region AAA PF00004.29 ELR18253.1 - 0.094 13.1 0.0 0.28 11.6 0.0 1.8 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) nos_propeller PF18764.1 ELR18253.1 - 0.1 12.6 0.9 23 5.0 0.0 4.0 4 0 0 4 4 3 0 Nitrous oxide reductase propeller repeat NB-ARC PF00931.22 ELR18253.1 - 0.11 11.6 0.0 0.19 10.9 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain DUF2075 PF09848.9 ELR18253.1 - 0.12 11.6 0.0 1.3 8.2 0.0 2.3 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) KAP_NTPase PF07693.14 ELR18253.1 - 0.14 11.4 0.0 0.84 8.8 0.0 2.1 1 1 1 2 2 2 0 KAP family P-loop domain ABC_tran PF00005.27 ELR18253.1 - 0.18 12.3 0.1 0.71 10.4 0.0 2.0 2 0 0 2 2 1 0 ABC transporter 120_Rick_ant PF12574.8 ELR18253.1 - 0.2 10.9 0.9 2.5 7.2 0.0 3.0 4 0 0 4 4 4 0 120 KDa Rickettsia surface antigen Roc PF08477.13 ELR18253.1 - 0.48 10.6 2.5 9.7 6.4 0.0 4.4 5 1 1 6 6 4 0 Ras of Complex, Roc, domain of DAPkinase DUF5570 PF17731.1 ELR18253.1 - 2.3 8.3 21.0 8.5 6.5 0.4 7.0 4 2 2 7 7 7 0 Family of unknown function (DUF5570) NMT_C PF02799.15 ELR18254.1 - 1.2e-77 260.2 0.0 1.9e-77 259.5 0.0 1.2 1 0 0 1 1 1 1 Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain NMT PF01233.19 ELR18254.1 - 1.4e-74 249.3 0.2 3.3e-74 248.1 0.0 1.8 2 0 0 2 2 2 1 Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain ICAT PF06384.11 ELR18254.1 - 0.0082 16.4 1.1 0.024 14.9 0.7 1.9 1 1 0 1 1 1 1 Beta-catenin-interacting protein ICAT Acetyltransf_9 PF13527.7 ELR18254.1 - 0.086 12.9 0.0 0.63 10.1 0.0 2.3 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain Spt20 PF12090.8 ELR18254.1 - 1.5 8.4 7.9 0.06 12.9 1.4 1.9 2 0 0 2 2 2 0 Spt20 family CCDC53 PF10152.9 ELR18254.1 - 2.3 8.6 9.8 0.081 13.3 1.3 2.2 2 0 0 2 2 2 0 Subunit CCDC53 of WASH complex DEAD PF00270.29 ELR18255.1 - 9.6e-47 159.0 0.0 1.4e-46 158.5 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ELR18255.1 - 2.1e-23 82.7 0.0 4.6e-23 81.7 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain SPRY PF00622.28 ELR18255.1 - 3.4e-23 82.0 0.2 5.9e-23 81.3 0.2 1.4 1 0 0 1 1 1 1 SPRY domain DUF3446 PF11928.8 ELR18255.1 - 0.0028 17.9 5.1 0.0068 16.7 5.1 1.6 1 0 0 1 1 1 1 Early growth response N-terminal domain IMUP PF15761.5 ELR18255.1 - 0.31 11.7 7.5 0.11 13.1 3.6 2.1 2 0 0 2 2 2 0 Immortalisation up-regulated protein SR-25 PF10500.9 ELR18255.1 - 1.5 8.4 9.4 2.4 7.7 9.4 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein DUF2053 PF09767.9 ELR18256.1 - 2.7e-56 190.1 3.6 4.4e-56 189.4 3.6 1.3 1 0 0 1 1 1 1 Predicted membrane protein (DUF2053) Rib_recp_KP_reg PF05104.12 ELR18257.1 - 0.16 13.0 18.1 0.34 11.9 18.1 1.6 1 0 0 1 1 1 0 Ribosome receptor lysine/proline rich region Sec62 PF03839.16 ELR18257.1 - 4.3 6.8 6.0 7.1 6.1 6.0 1.3 1 0 0 1 1 1 0 Translocation protein Sec62 AP3D1 PF06375.11 ELR18257.1 - 6 7.1 31.6 2.8 8.2 21.0 2.2 2 0 0 2 2 2 0 AP-3 complex subunit delta-1 Eapp_C PF10238.9 ELR18257.1 - 8.3 6.5 9.7 11 6.0 6.7 2.1 2 0 0 2 2 2 0 E2F-associated phosphoprotein CwfJ_C_1 PF04677.15 ELR18258.1 - 6.1e-32 110.1 0.0 9.3e-32 109.5 0.0 1.2 1 0 0 1 1 1 1 Protein similar to CwfJ C-terminus 1 CwfJ_C_2 PF04676.14 ELR18258.1 - 8.9e-26 90.7 0.0 1.9e-25 89.6 0.0 1.6 1 0 0 1 1 1 1 Protein similar to CwfJ C-terminus 2 ABC_tran_CTD PF16326.5 ELR18258.1 - 0.26 11.6 2.0 0.54 10.5 2.0 1.4 1 0 0 1 1 1 0 ABC transporter C-terminal domain Metallophos PF00149.28 ELR18259.1 - 2.5e-06 28.1 1.3 2.3e-05 25.0 0.2 2.5 1 1 2 3 3 3 1 Calcineurin-like phosphoesterase RFX_DNA_binding PF02257.15 ELR18260.1 - 1.1e-17 64.4 0.0 2.5e-17 63.2 0.0 1.6 1 0 0 1 1 1 1 RFX DNA-binding domain Pox_D5 PF03288.16 ELR18260.1 - 0.003 18.0 0.0 0.011 16.2 0.0 1.9 2 0 0 2 2 2 1 Poxvirus D5 protein-like Nse4_C PF08743.10 ELR18261.1 - 1.1e-27 96.1 0.4 3.8e-27 94.4 0.0 2.1 2 0 0 2 2 2 1 Nse4 C-terminal Nse4-Nse3_bdg PF15412.6 ELR18261.1 - 0.0019 18.3 0.0 0.0019 18.3 0.0 3.6 4 0 0 4 4 4 1 Binding domain of Nse4/EID3 to Nse3-MAGE DUF3246 PF11596.8 ELR18261.1 - 0.091 12.2 0.6 0.18 11.2 0.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3246) PGA2 PF07543.12 ELR18261.1 - 1.7 8.6 24.9 2 8.4 11.4 3.3 2 1 1 3 3 3 0 Protein trafficking PGA2 Pmp3 PF01679.17 ELR18262.1 - 1e-16 60.8 13.3 1.3e-16 60.5 13.3 1.2 1 0 0 1 1 1 1 Proteolipid membrane potential modulator DUF3681 PF12442.8 ELR18262.1 - 0.04 14.4 0.4 0.067 13.7 0.3 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3681) FKBP_C PF00254.28 ELR18263.1 - 2e-30 105.0 0.0 3.5e-30 104.2 0.0 1.4 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase Sec2p PF06428.11 ELR18263.1 - 0.02 14.8 0.8 0.02 14.8 0.8 1.8 2 0 0 2 2 2 0 GDP/GTP exchange factor Sec2p Presenilin PF01080.17 ELR18263.1 - 0.073 11.8 2.7 0.086 11.6 2.7 1.1 1 0 0 1 1 1 0 Presenilin Ndc1_Nup PF09531.10 ELR18263.1 - 0.074 11.7 11.3 0.088 11.5 11.3 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Sirohm_synth_M PF14824.6 ELR18263.1 - 0.26 10.8 0.1 0.26 10.8 0.1 2.2 2 0 0 2 2 2 0 Sirohaem biosynthesis protein central DUF3138 PF11336.8 ELR18263.1 - 0.31 9.6 3.5 0.46 9.0 3.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) Amelogenin PF02948.15 ELR18263.1 - 1.6 9.4 8.0 0.85 10.2 5.1 1.8 1 1 1 2 2 2 0 Amelogenin CDC27 PF09507.10 ELR18263.1 - 2.5 7.4 25.1 3.3 7.0 25.1 1.2 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 SOG2 PF10428.9 ELR18263.1 - 4.1 6.5 14.3 5.2 6.1 14.3 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein SRP-alpha_N PF04086.13 ELR18263.1 - 4.2 7.2 18.4 5.2 6.9 18.4 1.2 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal DUF2981 PF11200.8 ELR18263.1 - 4.8 6.8 10.3 6 6.5 10.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2981) Hamartin PF04388.12 ELR18263.1 - 5.7 5.5 14.6 6.8 5.2 14.6 1.0 1 0 0 1 1 1 0 Hamartin protein Menin PF05053.13 ELR18263.1 - 8.2 4.6 9.9 12 4.1 9.9 1.2 1 0 0 1 1 1 0 Menin NAD_binding_6 PF08030.12 ELR18264.1 - 6.1e-30 104.4 0.0 9.2e-30 103.8 0.0 1.3 1 0 0 1 1 1 1 Ferric reductase NAD binding domain Ferric_reduct PF01794.19 ELR18264.1 - 1.1e-20 74.0 8.8 2.4e-20 72.9 8.8 1.6 1 0 0 1 1 1 1 Ferric reductase like transmembrane component FAD_binding_8 PF08022.12 ELR18264.1 - 2.5e-18 66.2 0.0 5e-18 65.2 0.0 1.5 1 0 0 1 1 1 1 FAD-binding domain FAD_binding_6 PF00970.24 ELR18264.1 - 0.00017 21.9 0.0 0.00038 20.8 0.0 1.6 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain C2 PF00168.30 ELR18265.1 - 1.1e-23 83.4 0.1 1.5e-23 83.0 0.1 1.2 1 0 0 1 1 1 1 C2 domain SR-25 PF10500.9 ELR18265.1 - 0.38 10.3 4.5 0.6 9.7 4.5 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein ABC2_membrane PF01061.24 ELR18266.1 - 5.7e-38 130.4 27.5 8.8e-38 129.8 27.5 1.3 1 0 0 1 1 1 1 ABC-2 type transporter ABC_tran PF00005.27 ELR18266.1 - 5.5e-28 98.2 0.0 9.2e-28 97.5 0.0 1.4 1 0 0 1 1 1 1 ABC transporter ABC2_membrane_3 PF12698.7 ELR18266.1 - 1.6e-05 24.2 23.6 2.4e-05 23.7 23.6 1.2 1 0 0 1 1 1 1 ABC-2 family transporter protein AAA_21 PF13304.6 ELR18266.1 - 4.7e-05 23.3 0.9 0.068 13.0 0.1 2.3 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_25 PF13481.6 ELR18266.1 - 0.00048 19.7 0.1 0.00089 18.9 0.1 1.3 1 0 0 1 1 1 1 AAA domain SMC_N PF02463.19 ELR18266.1 - 0.0029 17.1 0.0 0.044 13.2 0.0 2.1 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 ELR18266.1 - 0.0041 16.8 0.1 0.0081 15.9 0.1 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_16 PF13191.6 ELR18266.1 - 0.0044 17.4 0.4 0.017 15.5 0.1 2.0 2 0 0 2 2 2 1 AAA ATPase domain RsgA_GTPase PF03193.16 ELR18266.1 - 0.0048 16.8 0.0 0.011 15.7 0.0 1.5 1 0 0 1 1 1 1 RsgA GTPase AAA_28 PF13521.6 ELR18266.1 - 0.021 15.1 0.1 0.021 15.1 0.1 2.0 2 1 0 2 2 2 0 AAA domain AAA_18 PF13238.6 ELR18266.1 - 0.028 14.9 0.0 0.079 13.5 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_23 PF13476.6 ELR18266.1 - 0.13 12.7 0.0 0.3 11.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 ELR18266.1 - 0.16 11.9 0.1 0.33 10.9 0.1 1.5 1 0 0 1 1 1 0 NACHT domain Erg28 PF03694.13 ELR18266.1 - 1.5 9.2 13.2 0.1 13.0 6.4 2.2 1 1 1 2 2 2 0 Erg28 like protein F-box-like PF12937.7 ELR18267.1 - 1.6e-12 47.1 0.7 4.6e-12 45.6 0.1 2.2 2 0 0 2 2 2 1 F-box-like WD40 PF00400.32 ELR18267.1 - 3.5e-08 34.0 18.8 0.16 12.9 0.2 7.3 7 0 0 7 7 7 5 WD domain, G-beta repeat F-box PF00646.33 ELR18267.1 - 0.076 12.9 0.6 0.3 11.0 0.6 2.0 1 1 0 1 1 1 0 F-box domain Cellulase PF00150.18 ELR18268.1 - 1.2e-45 156.2 0.2 1.5e-45 155.8 0.2 1.1 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) Glyco_hydro_53 PF07745.13 ELR18268.1 - 0.063 12.2 0.0 0.11 11.4 0.0 1.3 1 0 0 1 1 1 0 Glycosyl hydrolase family 53 PRCC PF10253.9 ELR18268.1 - 0.25 12.1 11.8 0.38 11.5 11.8 1.2 1 0 0 1 1 1 0 Mitotic checkpoint regulator, MAD2B-interacting Calcipressin PF04847.12 ELR18269.1 - 4e-11 43.0 1.1 7.9e-11 42.0 1.1 1.5 1 1 0 1 1 1 1 Calcipressin Hydrolase PF00702.26 ELR18270.1 - 2.7e-20 73.6 0.0 3.6e-20 73.2 0.0 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 ELR18270.1 - 1.5e-17 64.2 0.0 1.7e-17 64.1 0.0 1.1 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 ELR18270.1 - 2.8e-06 27.3 0.1 7e-06 26.0 0.1 1.7 1 0 0 1 1 1 1 HAD-hyrolase-like HAD PF12710.7 ELR18270.1 - 0.036 14.4 0.1 0.047 14.1 0.1 1.3 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase TLD PF07534.16 ELR18272.1 - 5.6e-32 110.9 0.0 1.3e-31 109.7 0.0 1.6 1 0 0 1 1 1 1 TLD WD40 PF00400.32 ELR18272.1 - 3.3e-06 27.7 7.7 3.5 8.6 0.0 5.8 5 0 0 5 5 5 2 WD domain, G-beta repeat RWD PF05773.22 ELR18272.1 - 0.011 16.0 0.0 0.025 14.8 0.0 1.6 1 0 0 1 1 1 0 RWD domain Hid1 PF12722.7 ELR18272.1 - 7.5 4.5 11.5 0.047 11.8 1.2 2.0 2 0 0 2 2 2 0 High-temperature-induced dauer-formation protein Laminin_G_3 PF13385.6 ELR18273.1 - 2.4e-08 34.3 1.4 2.4e-08 34.3 1.4 1.9 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily CHB_HEX_C_1 PF13290.6 ELR18273.1 - 0.005 16.8 0.0 0.011 15.7 0.0 1.7 1 0 0 1 1 1 1 Chitobiase/beta-hexosaminidase C-terminal domain EGF_2 PF07974.13 ELR18273.1 - 5.9 7.3 10.8 6.8 7.2 1.0 3.2 3 0 0 3 3 3 0 EGF-like domain Ephrin_rec_like PF07699.13 ELR18273.1 - 8.8 6.2 16.9 3.1 7.6 0.1 4.6 5 0 0 5 5 5 0 Putative ephrin-receptor like Ribosomal_S9 PF00380.19 ELR18274.1 - 6e-42 143.0 0.1 9.4e-42 142.4 0.1 1.3 1 0 0 1 1 1 1 Ribosomal protein S9/S16 DUF2875 PF11394.8 ELR18274.1 - 0.1 11.5 0.0 2.6 6.8 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2875) PA-IIL PF07472.11 ELR18274.1 - 0.14 12.5 0.1 0.32 11.3 0.0 1.6 2 0 0 2 2 2 0 Fucose-binding lectin II (PA-IIL) Ras PF00071.22 ELR18275.1 - 4.6e-32 110.9 0.0 5.8e-32 110.5 0.0 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR18275.1 - 8.9e-14 51.7 0.0 5.2e-13 49.3 0.0 2.0 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase AAA_7 PF12775.7 ELR18275.1 - 0.08 12.5 0.1 0.15 11.5 0.1 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region Arf PF00025.21 ELR18275.1 - 0.14 11.6 0.0 0.21 11.0 0.0 1.4 1 1 0 1 1 1 0 ADP-ribosylation factor family DUF4839 PF16127.5 ELR18276.1 - 0.18 11.9 0.0 0.35 11.0 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4839) CLU PF13236.6 ELR18277.1 - 4.7e-54 183.6 0.0 2e-53 181.5 0.0 2.0 2 0 0 2 2 2 1 Clustered mitochondria eIF3_p135 PF12807.7 ELR18277.1 - 3.4e-07 30.5 0.4 8.1e-07 29.2 0.0 1.8 2 0 0 2 2 2 1 Translation initiation factor eIF3 subunit 135 CUE PF02845.16 ELR18278.1 - 2.3e-07 30.4 0.0 4e-07 29.6 0.0 1.2 1 0 0 1 1 1 1 CUE domain zf-RanBP PF00641.18 ELR18278.1 - 0.0025 17.1 4.9 0.0038 16.5 4.9 1.3 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others Pkinase_Tyr PF07714.17 ELR18280.1 - 6.6e-73 245.2 0.0 7.1e-24 84.5 0.0 5.2 4 1 1 5 5 5 5 Protein tyrosine kinase Pkinase PF00069.25 ELR18280.1 - 3.6e-66 223.2 0.0 1.5e-23 83.5 0.0 5.1 3 2 2 5 5 5 4 Protein kinase domain Guanylate_cyc PF00211.20 ELR18280.1 - 1.3e-10 41.2 0.0 0.00014 21.6 0.0 2.8 3 0 0 3 3 3 2 Adenylate and Guanylate cyclase catalytic domain APH PF01636.23 ELR18280.1 - 1.7e-07 31.4 1.8 0.016 15.2 0.0 4.1 3 1 1 4 4 4 3 Phosphotransferase enzyme family FTA2 PF13095.6 ELR18280.1 - 0.01 15.5 0.0 1.1 8.9 0.0 2.7 2 1 0 3 3 3 0 Kinetochore Sim4 complex subunit FTA2 EGF_2 PF07974.13 ELR18280.1 - 0.036 14.4 1.0 0.092 13.1 1.0 1.7 1 0 0 1 1 1 0 EGF-like domain DUF3984 PF13136.6 ELR18281.1 - 0.072 12.5 2.7 0.1 12.0 2.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3984) SR-25 PF10500.9 ELR18281.1 - 0.34 10.5 7.6 0.025 14.2 2.8 1.5 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein Peptidase_M28 PF04389.17 ELR18282.1 - 1.2e-06 28.4 0.0 3.7e-06 26.8 0.0 1.7 1 1 0 1 1 1 1 Peptidase family M28 Nicastrin PF05450.15 ELR18282.1 - 0.15 11.5 0.0 0.21 11.0 0.0 1.3 1 0 0 1 1 1 0 Nicastrin THAP PF05485.12 ELR18287.1 - 0.057 14.3 0.1 0.077 13.9 0.1 1.2 1 0 0 1 1 1 0 THAP domain DUF1993 PF09351.10 ELR18287.1 - 0.092 12.9 0.3 0.11 12.6 0.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1993) CCSAP PF15748.5 ELR18291.1 - 1.7 8.7 20.1 2 8.5 20.1 1.1 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated SpoIIIAC PF06686.11 ELR18293.1 - 0.67 10.2 4.7 0.78 10.0 0.2 2.1 2 0 0 2 2 2 0 Stage III sporulation protein AC/AD protein family Mcp5_PH PF12814.7 ELR18295.1 - 0.041 14.0 0.5 0.13 12.4 0.3 1.8 1 1 1 2 2 2 0 Meiotic cell cortex C-terminal pleckstrin homology PP2C PF00481.21 ELR18296.1 - 0.00013 21.7 0.1 0.0018 17.9 0.1 2.0 1 1 0 1 1 1 1 Protein phosphatase 2C dUTPase PF00692.19 ELR18300.1 - 5.5e-12 45.5 0.1 2.3e-11 43.5 0.1 1.6 1 1 1 2 2 2 1 dUTPase Thioredoxin PF00085.20 ELR18302.1 - 2.8e-08 33.7 0.0 4.5e-08 33.0 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin AhpC-TSA PF00578.21 ELR18302.1 - 0.046 13.6 0.0 0.066 13.1 0.0 1.3 1 0 0 1 1 1 0 AhpC/TSA family Thioredoxin_2 PF13098.6 ELR18302.1 - 0.055 13.9 0.3 0.32 11.5 0.1 2.1 1 1 1 2 2 2 0 Thioredoxin-like domain Redoxin PF08534.10 ELR18302.1 - 0.091 12.5 0.1 0.2 11.4 0.0 1.5 1 1 0 1 1 1 0 Redoxin Thioredoxin_9 PF14595.6 ELR18302.1 - 0.16 11.7 0.0 0.26 11.0 0.0 1.4 1 0 0 1 1 1 0 Thioredoxin DUF3040 PF11239.8 ELR18304.1 - 0.0016 18.7 0.1 0.0047 17.2 0.1 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF3040) DAG1 PF05454.11 ELR18304.1 - 0.013 14.8 0.1 0.019 14.3 0.1 1.2 1 0 0 1 1 1 0 Dystroglycan (Dystrophin-associated glycoprotein 1) DUF2157 PF09925.9 ELR18304.1 - 0.02 14.7 0.0 0.029 14.1 0.0 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2157) ETRAMP PF09716.10 ELR18304.1 - 0.046 13.8 0.1 0.058 13.5 0.1 1.4 1 1 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) DUF2207 PF09972.9 ELR18304.1 - 0.056 12.2 0.0 0.056 12.2 0.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Ank_4 PF13637.6 ELR18305.1 - 9.2e-05 22.9 0.0 0.81 10.3 0.0 3.5 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 ELR18305.1 - 0.012 16.2 0.0 0.04 14.5 0.0 1.9 1 1 0 1 1 1 0 Ankyrin repeats (3 copies) Ank_3 PF13606.6 ELR18305.1 - 0.17 12.6 0.1 30 5.6 0.0 3.0 3 0 0 3 3 3 0 Ankyrin repeat DHBP_synthase PF00926.19 ELR18306.1 - 2.4e-78 262.1 0.1 7.3e-78 260.5 0.0 1.8 2 0 0 2 2 2 1 3,4-dihydroxy-2-butanone 4-phosphate synthase GTP_cyclohydro2 PF00925.20 ELR18306.1 - 2.5e-50 170.2 0.1 2.1e-49 167.2 0.0 2.1 2 0 0 2 2 2 1 GTP cyclohydrolase II DMRL_synthase PF00885.19 ELR18306.1 - 4e-40 136.9 0.0 8.2e-40 135.9 0.0 1.6 1 0 0 1 1 1 1 6,7-dimethyl-8-ribityllumazine synthase RepL PF05732.11 ELR18306.1 - 0.0071 15.8 0.0 1.8 7.9 0.0 2.4 2 0 0 2 2 2 2 Firmicute plasmid replication protein (RepL) KdgT PF03812.13 ELR18306.1 - 0.17 11.2 4.9 5.3 6.3 0.1 2.1 2 0 0 2 2 2 0 2-keto-3-deoxygluconate permease RibD_C PF01872.17 ELR18307.1 - 2.4e-34 118.9 0.3 3.2e-34 118.5 0.3 1.2 1 0 0 1 1 1 1 RibD C-terminal domain dCMP_cyt_deam_1 PF00383.23 ELR18307.1 - 1.2e-05 25.1 0.0 2.4e-05 24.1 0.0 1.5 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region Inv-AAD PF18785.1 ELR18307.1 - 0.012 15.5 0.0 0.023 14.6 0.0 1.4 1 0 0 1 1 1 0 Invertebrate-AID/APOBEC-deaminase PTPlike_phytase PF14566.6 ELR18308.1 - 3.3e-95 316.4 0.2 7.1e-52 175.6 0.2 2.8 2 0 0 2 2 2 2 Inositol hexakisphosphate Y_phosphatase PF00102.27 ELR18308.1 - 0.022 14.3 0.0 1.9 8.0 0.0 2.4 2 0 0 2 2 2 0 Protein-tyrosine phosphatase Eco57I PF07669.11 ELR18308.1 - 0.042 14.3 0.6 1.2 9.6 0.4 2.6 2 0 0 2 2 2 0 Eco57I restriction-modification methylase CRAL_TRIO PF00650.20 ELR18309.1 - 2.4e-08 33.8 0.0 3.9e-08 33.2 0.0 1.4 1 0 0 1 1 1 1 CRAL/TRIO domain BTB_2 PF02214.22 ELR18310.1 - 1e-16 61.0 0.0 1.8e-16 60.2 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain CDC45 PF02724.14 ELR18310.1 - 0.00095 17.6 5.9 0.00095 17.6 5.9 2.0 1 1 1 2 2 2 1 CDC45-like protein BTB_3 PF16017.5 ELR18310.1 - 0.18 11.9 0.1 0.5 10.5 0.0 1.7 2 0 0 2 2 2 0 BTB/POZ domain TFIIA PF03153.13 ELR18310.1 - 0.76 9.7 13.4 1.4 8.8 13.4 1.4 1 1 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Sigma70_ner PF04546.13 ELR18310.1 - 1.5 8.7 20.2 0.21 11.4 7.1 2.1 2 0 0 2 2 2 0 Sigma-70, non-essential region TLP-20 PF06088.11 ELR18310.1 - 1.8 8.5 4.8 0.47 10.3 0.1 2.0 2 0 0 2 2 2 0 Nucleopolyhedrovirus telokin-like protein-20 (TLP20) RXT2_N PF08595.11 ELR18310.1 - 3.9 7.5 14.9 0.51 10.3 6.8 2.2 2 0 0 2 2 2 0 RXT2-like, N-terminal D123 PF07065.14 ELR18310.1 - 5.2 6.1 9.1 0.11 11.6 1.4 1.8 2 0 0 2 2 2 0 D123 Cwf_Cwc_15 PF04889.12 ELR18310.1 - 8.6 6.0 34.5 0.026 14.3 13.8 2.4 2 1 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein PTPlike_phytase PF14566.6 ELR18311.1 - 1.4e-40 138.9 0.7 1.4e-40 138.9 0.7 2.2 2 1 0 2 2 2 1 Inositol hexakisphosphate zf-RanBP PF00641.18 ELR18312.1 - 2.1e-05 23.7 6.2 3e-05 23.3 6.2 1.2 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others CUE PF02845.16 ELR18312.1 - 3.4e-05 23.4 0.0 5.4e-05 22.8 0.0 1.4 1 0 0 1 1 1 1 CUE domain HTH_8 PF02954.19 ELR18312.1 - 0.012 15.4 0.0 0.021 14.6 0.0 1.4 1 0 0 1 1 1 0 Bacterial regulatory protein, Fis family Vps36-NZF-N PF16988.5 ELR18312.1 - 0.02 14.3 3.0 0.095 12.1 3.0 1.9 1 1 0 1 1 1 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain DMA PF03474.14 ELR18312.1 - 0.038 13.6 0.0 0.09 12.4 0.0 1.6 2 0 0 2 2 2 0 DMRTA motif CRAL_TRIO PF00650.20 ELR18313.1 - 6.1e-33 113.8 0.0 8.1e-33 113.4 0.0 1.2 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_2 PF13716.6 ELR18313.1 - 7.8e-08 32.6 0.0 1.1e-07 32.1 0.0 1.2 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain DUF1681 PF07933.14 ELR18314.1 - 5.6e-08 32.6 0.1 9.8e-08 31.8 0.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1681) PTEN_C2 PF10409.9 ELR18315.1 - 7.8e-13 48.4 0.4 1.8e-12 47.2 0.4 1.5 1 0 0 1 1 1 1 C2 domain of PTEN tumour-suppressor protein DSPc PF00782.20 ELR18315.1 - 0.0035 17.2 0.0 0.0075 16.1 0.0 1.6 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 ELR18315.1 - 0.009 15.6 0.1 0.032 13.8 0.0 1.9 2 0 0 2 2 2 1 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.6 ELR18315.1 - 0.012 15.6 0.0 0.035 14.1 0.0 1.8 2 0 0 2 2 2 0 Tyrosine phosphatase family CDKN3 PF05706.12 ELR18315.1 - 0.094 12.4 0.0 0.16 11.6 0.0 1.3 1 0 0 1 1 1 0 Cyclin-dependent kinase inhibitor 3 (CDKN3) PTPlike_phytase PF14566.6 ELR18315.1 - 0.26 11.4 0.0 0.26 11.4 0.0 2.8 3 0 0 3 3 3 0 Inositol hexakisphosphate UPF0231 PF06062.11 ELR18315.1 - 0.42 10.9 4.0 1.1 9.6 4.0 1.7 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0231) DUF1722 PF08349.11 ELR18316.1 - 0.0066 16.7 0.1 0.011 16.0 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1722) Rotamase PF00639.21 ELR18316.1 - 0.07 14.1 0.4 0.16 13.0 0.4 1.5 1 0 0 1 1 1 0 PPIC-type PPIASE domain TAF8_C PF10406.9 ELR18316.1 - 0.079 13.5 1.3 0.14 12.7 0.3 2.0 2 0 0 2 2 2 0 Transcription factor TFIID complex subunit 8 C-term BTB_2 PF02214.22 ELR18316.1 - 0.16 12.3 0.1 0.34 11.3 0.1 1.6 1 0 0 1 1 1 0 BTB/POZ domain Amidohydro_3 PF07969.11 ELR18317.1 - 3.6e-83 280.6 0.5 4.5e-83 280.3 0.5 1.0 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_1 PF01979.20 ELR18317.1 - 4.8e-20 72.2 0.0 1.9e-17 63.6 0.0 3.1 2 1 0 2 2 2 2 Amidohydrolase family adh_short PF00106.25 ELR18318.1 - 2.3e-55 187.1 0.0 2.7e-55 186.8 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ELR18318.1 - 1.1e-35 123.3 0.0 1.6e-35 122.8 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ELR18318.1 - 3.1e-18 66.3 0.1 4.5e-18 65.8 0.1 1.1 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.6 ELR18318.1 - 0.00014 21.8 0.5 0.00048 20.1 0.5 1.8 2 0 0 2 2 2 1 NAD(P)H-binding Epimerase PF01370.21 ELR18318.1 - 0.00047 19.7 0.1 0.00079 19.0 0.1 1.4 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Eno-Rase_NADH_b PF12242.8 ELR18318.1 - 0.0037 17.0 0.3 0.0093 15.7 0.3 1.6 1 0 0 1 1 1 1 NAD(P)H binding domain of trans-2-enoyl-CoA reductase GDP_Man_Dehyd PF16363.5 ELR18318.1 - 0.0039 16.6 0.1 0.0072 15.8 0.1 1.5 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase Sacchrp_dh_NADP PF03435.18 ELR18318.1 - 0.0055 17.0 0.1 0.0089 16.3 0.1 1.4 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain Polysacc_synt_2 PF02719.15 ELR18318.1 - 0.0071 15.5 0.1 0.0089 15.2 0.1 1.1 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein Pyr_redox_2 PF07992.14 ELR18318.1 - 0.0087 15.3 0.1 0.012 14.8 0.1 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase ApbA PF02558.16 ELR18318.1 - 0.014 15.1 0.1 0.022 14.4 0.1 1.2 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA RRF PF01765.19 ELR18318.1 - 0.095 12.7 0.6 2.9 7.8 0.5 2.2 2 0 0 2 2 2 0 Ribosome recycling factor DUF1776 PF08643.10 ELR18318.1 - 0.1 11.9 0.0 0.17 11.3 0.0 1.3 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) 2-Hacid_dh_C PF02826.19 ELR18318.1 - 0.11 11.9 0.0 0.16 11.3 0.0 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Pyr_redox_3 PF13738.6 ELR18318.1 - 0.12 11.6 0.1 0.19 11.0 0.1 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase PHA-1 PF06542.11 ELR18318.1 - 0.16 10.7 0.0 0.22 10.3 0.0 1.1 1 0 0 1 1 1 0 Regulator protein PHA-1 Glyco_transf_49 PF13896.6 ELR18319.1 - 4.5e-53 180.7 0.0 2.5e-42 145.4 0.0 2.2 1 1 1 2 2 2 2 Glycosyl-transferase for dystroglycan fn3 PF00041.21 ELR18319.1 - 0.0093 16.3 0.0 0.025 14.9 0.0 1.6 1 0 0 1 1 1 1 Fibronectin type III domain Glycos_transf_2 PF00535.26 ELR18319.1 - 0.14 12.0 0.0 0.29 10.9 0.0 1.5 1 0 0 1 1 1 0 Glycosyl transferase family 2 BAR PF03114.18 ELR18320.1 - 7.4e-31 107.6 0.4 9.8e-31 107.2 0.4 1.1 1 0 0 1 1 1 1 BAR domain SH3_9 PF14604.6 ELR18320.1 - 4.4e-15 55.3 0.0 7.4e-15 54.5 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 ELR18320.1 - 7.5e-13 47.9 0.0 1.3e-12 47.1 0.0 1.4 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 ELR18320.1 - 4.6e-11 42.2 0.0 8.8e-11 41.3 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain Pericardin_rpt PF07054.11 ELR18320.1 - 0.0026 17.9 46.7 0.17 12.1 26.5 2.8 2 0 0 2 2 2 2 Pericardin like repeat SYF2 PF08231.12 ELR18320.1 - 0.0047 17.3 1.4 0.0077 16.6 0.3 1.8 2 0 0 2 2 2 1 SYF2 splicing factor Arfaptin PF06456.13 ELR18320.1 - 0.049 13.2 1.7 0.27 10.8 1.7 2.0 1 1 0 1 1 1 0 Arfaptin-like domain KxDL PF10241.9 ELR18320.1 - 0.17 12.2 0.4 0.38 11.0 0.4 1.6 1 0 0 1 1 1 0 Uncharacterized conserved protein Vps5 PF09325.10 ELR18320.1 - 0.18 11.3 0.8 2.6 7.6 0.1 2.1 2 0 0 2 2 2 0 Vps5 C terminal like UCH PF00443.29 ELR18321.1 - 5.9e-59 199.6 0.0 1.1e-58 198.8 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase DUSP PF06337.12 ELR18321.1 - 1.4e-20 73.7 0.0 3e-14 53.4 0.0 2.4 2 0 0 2 2 2 2 DUSP domain UCH_1 PF13423.6 ELR18321.1 - 1.6e-18 67.4 0.0 4.4e-17 62.7 0.0 2.5 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP PF02148.19 ELR18321.1 - 2.9e-13 49.9 10.9 2.9e-13 49.9 10.9 3.2 3 0 0 3 3 3 1 Zn-finger in ubiquitin-hydrolases and other protein Ank_4 PF13637.6 ELR18322.1 - 1.7e-18 66.7 0.5 4e-15 56.0 0.2 2.7 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 ELR18322.1 - 1.1e-16 61.1 0.9 1.8e-12 47.7 0.1 2.2 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 ELR18322.1 - 1.7e-15 56.9 0.2 1.5e-12 47.4 0.1 2.7 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 ELR18322.1 - 5.3e-15 55.1 1.1 7.7e-07 29.3 0.0 3.2 3 0 0 3 3 3 2 Ankyrin repeat Ank_3 PF13606.6 ELR18322.1 - 7.6e-14 50.5 0.5 3.8e-07 29.9 0.0 3.5 3 0 0 3 3 3 2 Ankyrin repeat F-box-like PF12937.7 ELR18322.1 - 2.3e-11 43.4 4.4 4.2e-11 42.6 4.4 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ELR18322.1 - 3.9e-08 33.0 3.0 9.7e-08 31.7 3.0 1.6 1 0 0 1 1 1 1 F-box domain F-box_4 PF15966.5 ELR18322.1 - 0.15 12.0 0.3 0.5 10.3 0.1 1.9 2 0 0 2 2 2 0 F-box Pkinase_Tyr PF07714.17 ELR18323.1 - 2.5e-36 125.3 0.0 2.2e-23 82.9 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 ELR18323.1 - 2e-34 119.2 0.0 1.7e-24 86.6 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain RIO1 PF01163.22 ELR18323.1 - 0.00077 19.1 0.0 0.0036 16.9 0.0 1.8 1 1 1 2 2 2 1 RIO1 family APH PF01636.23 ELR18323.1 - 0.051 13.5 2.2 0.081 12.8 0.5 1.9 2 1 0 2 2 2 0 Phosphotransferase enzyme family FTA2 PF13095.6 ELR18323.1 - 0.16 11.6 0.1 0.86 9.2 0.0 2.1 3 0 0 3 3 3 0 Kinetochore Sim4 complex subunit FTA2 DUF755 PF05501.11 ELR18324.1 - 0.0039 17.5 26.9 0.0039 17.5 26.9 3.7 3 0 0 3 3 3 2 Domain of unknown function (DUF755) SR-25 PF10500.9 ELR18324.1 - 0.018 14.6 74.1 0.09 12.4 11.6 4.4 3 1 1 4 4 4 0 Nuclear RNA-splicing-associated protein Cir_N PF10197.9 ELR18324.1 - 0.019 15.1 15.4 0.019 15.1 15.4 6.9 8 1 0 8 8 8 0 N-terminal domain of CBF1 interacting co-repressor CIR Dicty_REP PF05086.12 ELR18324.1 - 0.021 12.9 9.0 0.032 12.2 9.0 1.5 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Med3 PF11593.8 ELR18324.1 - 0.064 12.4 10.8 0.11 11.6 10.8 1.3 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal PH PF00169.29 ELR18326.1 - 6.1e-13 49.2 0.0 8.8e-13 48.7 0.0 1.2 1 0 0 1 1 1 1 PH domain PH_11 PF15413.6 ELR18326.1 - 0.071 13.5 0.1 0.16 12.4 0.1 1.6 1 1 0 1 1 1 0 Pleckstrin homology domain Coq4 PF05019.13 ELR18327.1 - 2.9e-70 236.0 0.0 3.6e-61 206.3 0.0 2.1 1 1 1 2 2 2 2 Coenzyme Q (ubiquinone) biosynthesis protein Coq4 Pex24p PF06398.11 ELR18328.1 - 5.9 5.8 5.9 7.9 5.4 5.9 1.1 1 0 0 1 1 1 0 Integral peroxisomal membrane peroxin EF-hand_1 PF00036.32 ELR18329.1 - 4e-29 98.0 10.8 2.3e-07 29.9 0.3 4.3 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 ELR18329.1 - 1.9e-25 89.1 4.3 2e-12 47.4 0.9 2.5 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_6 PF13405.6 ELR18329.1 - 5.6e-24 82.0 4.6 1.6e-07 30.7 0.1 4.3 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.6 ELR18329.1 - 2.5e-21 74.2 11.2 1.2e-06 27.7 0.4 4.4 4 0 0 4 4 4 4 EF hand EF-hand_8 PF13833.6 ELR18329.1 - 3.1e-16 59.0 12.8 2.1e-08 33.9 3.0 4.2 2 2 2 4 4 4 4 EF-hand domain pair EF-hand_9 PF14658.6 ELR18329.1 - 1.9e-08 34.5 0.0 0.00034 20.9 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.7 ELR18329.1 - 4.7e-07 29.7 2.5 0.008 16.1 0.2 3.0 1 1 2 3 3 3 2 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 ELR18329.1 - 2e-05 24.9 11.6 0.0017 18.7 0.0 3.7 2 2 1 3 3 2 2 Secreted protein acidic and rich in cysteine Ca binding region Dockerin_1 PF00404.18 ELR18329.1 - 0.0013 18.9 2.8 0.65 10.2 0.4 3.5 2 2 2 4 4 4 1 Dockerin type I domain Caleosin PF05042.13 ELR18329.1 - 0.028 14.4 0.4 2.7 7.9 0.0 3.1 2 2 2 4 4 4 0 Caleosin related protein SpoVT_C PF15714.5 ELR18329.1 - 0.053 13.6 2.0 0.088 12.9 2.0 1.4 1 0 0 1 1 1 0 Stage V sporulation protein T C-terminal, transcription factor AAA_23 PF13476.6 ELR18329.1 - 0.17 12.4 10.6 0.24 11.9 10.6 1.4 1 0 0 1 1 1 0 AAA domain HSP70 PF00012.20 ELR18329.1 - 0.7 8.0 11.5 1.2 7.3 10.2 1.8 1 1 0 2 2 2 0 Hsp70 protein Agouti PF05039.12 ELR18329.1 - 4.1 8.2 9.7 9.4 7.0 9.7 1.6 1 0 0 1 1 1 0 Agouti protein Presenilin PF01080.17 ELR18329.1 - 7.7 5.2 10.0 9.6 4.8 10.0 1.1 1 0 0 1 1 1 0 Presenilin MORN PF02493.20 ELR18330.1 - 2.6e-46 152.8 61.7 1.6e-08 33.9 1.0 8.8 9 0 0 9 9 9 8 MORN repeat F-box-like PF12937.7 ELR18330.1 - 2.2e-12 46.7 0.0 8.5e-12 44.8 0.0 1.9 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 ELR18330.1 - 1.3e-06 28.1 0.0 2.6e-06 27.2 0.0 1.5 1 0 0 1 1 1 1 F-box domain Stealth_CR1 PF17101.5 ELR18330.1 - 0.47 10.2 3.5 1.3 8.8 3.5 1.8 1 0 0 1 1 1 0 Stealth protein CR1, conserved region 1 DUF1768 PF08719.11 ELR18331.1 - 3.1e-16 60.1 0.1 3.4e-16 59.9 0.1 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1768) PAS_9 PF13426.7 ELR18332.1 - 0.0021 18.3 0.0 0.0037 17.5 0.0 1.4 1 0 0 1 1 1 1 PAS domain Zn_clus PF00172.18 ELR18332.1 - 0.0022 18.1 12.7 0.0037 17.3 12.7 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain PAS_3 PF08447.12 ELR18332.1 - 0.032 14.5 0.0 0.055 13.8 0.0 1.4 1 0 0 1 1 1 0 PAS fold CCDC85 PF10226.9 ELR18332.1 - 0.074 12.7 0.1 0.17 11.5 0.1 1.6 1 0 0 1 1 1 0 CCDC85 family AT_hook PF02178.19 ELR18332.1 - 8.4 6.6 6.8 30 5.0 6.8 1.9 1 0 0 1 1 1 0 AT hook motif SPX PF03105.19 ELR18332.1 - 9.9 6.0 17.3 2.6 7.9 0.0 2.7 2 1 1 3 3 3 0 SPX domain UBX PF00789.20 ELR18333.1 - 2.4e-16 59.7 0.1 6.3e-16 58.4 0.0 1.8 2 0 0 2 2 2 1 UBX domain ZZ PF00569.17 ELR18333.1 - 9.6e-10 38.1 8.6 1.5e-09 37.5 8.6 1.3 1 0 0 1 1 1 1 Zinc finger, ZZ type UBA PF00627.31 ELR18333.1 - 2e-06 27.5 0.3 5.7e-06 26.1 0.3 1.8 1 0 0 1 1 1 1 UBA/TS-N domain Atg14 PF10186.9 ELR18333.1 - 0.17 10.9 5.9 0.23 10.5 5.9 1.3 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF4195 PF13836.6 ELR18333.1 - 0.19 11.9 0.5 0.31 11.2 0.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4195) C1_2 PF03107.16 ELR18333.1 - 0.49 10.7 6.6 0.86 10.0 6.6 1.3 1 0 0 1 1 1 0 C1 domain RR_TM4-6 PF06459.12 ELR18333.1 - 3 7.6 11.3 4.5 7.0 11.3 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF2057 PF09829.9 ELR18333.1 - 3.6 7.7 9.4 0.61 10.2 2.3 2.2 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2057) DUF4407 PF14362.6 ELR18333.1 - 5.8 6.2 12.3 8.6 5.6 12.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Aldo_ket_red PF00248.21 ELR18334.1 - 1.2e-70 238.0 0.0 1.4e-70 237.8 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Hep_59 PF07052.11 ELR18335.1 - 1e-22 80.8 3.9 1e-22 80.8 3.9 2.6 3 0 0 3 3 3 1 Hepatocellular carcinoma-associated antigen 59 p450 PF00067.22 ELR18336.1 - 5.1e-70 236.5 0.0 7.8e-70 235.9 0.0 1.2 1 0 0 1 1 1 1 Cytochrome P450 OTU PF02338.19 ELR18338.1 - 7.2e-06 26.5 0.0 1.2e-05 25.8 0.0 1.3 1 0 0 1 1 1 1 OTU-like cysteine protease zf-C2H2_2 PF12756.7 ELR18338.1 - 0.11 12.8 0.0 0.26 11.6 0.0 1.6 2 0 0 2 2 2 0 C2H2 type zinc-finger (2 copies) PAD_porph PF04371.15 ELR18339.1 - 1.4e-67 228.3 0.0 1.8e-67 227.9 0.0 1.1 1 0 0 1 1 1 1 Porphyromonas-type peptidyl-arginine deiminase Amidinotransf PF02274.17 ELR18339.1 - 0.065 12.3 0.1 0.14 11.2 0.0 1.5 2 0 0 2 2 2 0 Amidinotransferase Hydrolase_6 PF13344.6 ELR18340.1 - 8.9e-20 70.7 0.0 2.1e-19 69.5 0.0 1.6 2 0 0 2 2 2 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 ELR18340.1 - 1.4e-13 50.7 0.0 3.9e-13 49.3 0.0 1.8 1 1 0 1 1 1 1 HAD-hyrolase-like Hydrolase PF00702.26 ELR18340.1 - 0.039 14.2 0.0 12 6.1 0.0 2.3 2 1 0 2 2 2 0 haloacid dehalogenase-like hydrolase Rad60-SLD PF11976.8 ELR18344.1 - 2.2e-12 46.6 0.0 2.9e-12 46.3 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.23 ELR18344.1 - 1.9e-05 24.3 0.0 2.6e-05 23.9 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin family YukD PF08817.10 ELR18344.1 - 0.0064 17.2 0.1 0.0096 16.6 0.1 1.3 1 1 0 1 1 1 1 WXG100 protein secretion system (Wss), protein YukD DUF3589 PF12141.8 ELR18345.1 - 0.056 12.0 0.0 0.076 11.6 0.0 1.1 1 0 0 1 1 1 0 Beta-mannosyltransferases Peptidase_C92 PF05708.12 ELR18345.1 - 0.07 13.2 0.5 0.22 11.6 0.0 1.9 2 1 1 3 3 3 0 Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family TFIIA PF03153.13 ELR18345.1 - 4.8 7.1 20.3 6.8 6.6 20.3 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF2968 PF11180.8 ELR18346.1 - 0.002 17.8 2.7 0.0024 17.5 2.7 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2968) Rubis-subs-bind PF09273.11 ELR18348.1 - 3.7e-11 43.8 0.8 1.1e-10 42.3 0.3 2.0 3 0 0 3 3 3 1 Rubisco LSMT substrate-binding SET PF00856.28 ELR18348.1 - 1.1e-09 38.9 0.0 2.3e-09 37.9 0.0 1.5 2 0 0 2 2 2 1 SET domain DUF1324 PF07038.11 ELR18348.1 - 0.13 12.5 0.0 0.3 11.3 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1324) DUF179 PF02622.15 ELR18349.1 - 9.8e-10 38.6 0.0 8e-09 35.7 0.0 2.1 2 0 0 2 2 2 1 Uncharacterized ACR, COG1678 DUF2514 PF10721.9 ELR18349.1 - 0.49 10.4 4.4 1.1 9.3 4.4 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF2514) Sacchrp_dh_C PF16653.5 ELR18350.1 - 1.7e-77 261.1 0.0 2.7e-77 260.5 0.0 1.3 1 0 0 1 1 1 1 Saccharopine dehydrogenase C-terminal domain Sacchrp_dh_NADP PF03435.18 ELR18350.1 - 4.2e-21 75.6 0.0 7.4e-21 74.8 0.0 1.4 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain Shikimate_DH PF01488.20 ELR18350.1 - 1.6e-07 31.4 0.0 3.4e-07 30.4 0.0 1.5 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase NAD_binding_2 PF03446.15 ELR18350.1 - 0.0018 18.5 0.0 0.0028 17.9 0.0 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase XdhC_C PF13478.6 ELR18350.1 - 0.069 13.7 0.1 0.13 12.7 0.1 1.5 1 0 0 1 1 1 0 XdhC Rossmann domain Pkinase_Tyr PF07714.17 ELR18351.1 - 2.8e-65 220.2 0.0 4.2e-65 219.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ELR18351.1 - 3.2e-58 197.2 0.0 5.7e-58 196.4 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Kelch_4 PF13418.6 ELR18351.1 - 8.1e-34 115.4 6.3 3.4e-08 33.3 0.0 6.4 6 0 0 6 6 6 5 Galactose oxidase, central domain Kelch_3 PF13415.6 ELR18351.1 - 4.3e-25 87.5 10.1 8.4e-06 25.9 0.1 6.8 6 0 0 6 6 6 5 Galactose oxidase, central domain Kelch_5 PF13854.6 ELR18351.1 - 1.7e-22 79.0 4.3 1e-05 25.4 0.0 6.4 6 0 0 6 6 6 4 Kelch motif Kelch_1 PF01344.25 ELR18351.1 - 2.3e-22 78.3 4.7 0.00017 21.1 0.0 5.9 6 0 0 6 6 6 4 Kelch motif Kelch_6 PF13964.6 ELR18351.1 - 8.2e-21 73.5 5.4 0.00085 19.5 0.1 6.0 4 2 2 6 6 6 5 Kelch motif Kelch_2 PF07646.15 ELR18351.1 - 6.6e-18 63.9 13.8 4.8e-06 26.3 0.0 5.9 7 0 0 7 7 6 4 Kelch motif Kdo PF06293.14 ELR18351.1 - 0.00046 19.6 0.1 0.0012 18.3 0.1 1.7 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 ELR18351.1 - 0.021 13.8 0.0 0.045 12.7 0.0 1.4 1 0 0 1 1 1 0 Haspin like kinase domain Pkinase_fungal PF17667.1 ELR18351.1 - 0.057 12.2 0.0 0.057 12.2 0.0 2.2 2 0 0 2 2 2 0 Fungal protein kinase Kinase-like PF14531.6 ELR18351.1 - 0.064 12.6 0.0 0.12 11.7 0.0 1.4 1 0 0 1 1 1 0 Kinase-like PCM1_C PF15717.5 ELR18351.1 - 0.12 11.1 6.6 0.16 10.6 6.6 1.1 1 0 0 1 1 1 0 Pericentriolar material 1 C terminus ATP11 PF06644.11 ELR18351.1 - 1.9 8.2 8.5 3.9 7.2 8.5 1.5 1 0 0 1 1 1 0 ATP11 protein F-box-like PF12937.7 ELR18354.1 - 0.00016 21.5 5.0 0.00023 21.0 0.0 2.8 2 1 0 2 2 2 1 F-box-like F-box PF00646.33 ELR18354.1 - 0.00022 21.0 0.1 0.00022 21.0 0.1 2.1 2 0 0 2 2 2 1 F-box domain FXR_C1 PF16096.5 ELR18355.1 - 1.1 9.5 0.0 1.1 9.5 0.0 2.8 3 0 0 3 3 3 0 Fragile X-related 1 protein C-terminal region 2 SQS_PSY PF00494.19 ELR18356.1 - 1.5e-51 175.4 0.1 1.9e-51 175.1 0.1 1.1 1 0 0 1 1 1 1 Squalene/phytoene synthase Pkinase PF00069.25 ELR18357.1 - 4e-58 196.9 0.1 2.4e-57 194.3 0.1 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR18357.1 - 2.6e-23 82.6 5.3 2e-16 60.1 0.7 3.0 2 1 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 ELR18357.1 - 2.8e-05 23.6 0.6 0.013 14.8 0.1 2.5 2 0 0 2 2 2 2 Kinase-like APH PF01636.23 ELR18357.1 - 0.0054 16.7 2.1 0.11 12.4 0.4 2.7 2 1 1 3 3 3 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 ELR18357.1 - 0.0072 15.3 0.1 0.011 14.8 0.1 1.3 1 0 0 1 1 1 1 Haspin like kinase domain Seadorna_VP7 PF07387.11 ELR18357.1 - 0.009 15.1 0.0 0.014 14.5 0.0 1.2 1 0 0 1 1 1 1 Seadornavirus VP7 Pkinase_C PF00433.24 ELR18357.1 - 0.051 14.3 0.2 0.051 14.3 0.2 2.6 3 0 0 3 3 3 0 Protein kinase C terminal domain IQ PF00612.27 ELR18358.1 - 4.3e-06 26.0 4.6 1.4e-05 24.5 4.6 2.0 1 0 0 1 1 1 1 IQ calmodulin-binding motif FYVE PF01363.21 ELR18358.1 - 0.055 13.6 8.9 0.1 12.8 8.9 1.4 1 0 0 1 1 1 0 FYVE zinc finger RPEL PF02755.15 ELR18358.1 - 0.067 12.9 0.3 0.18 11.6 0.3 1.8 1 0 0 1 1 1 0 RPEL repeat FYVE_2 PF02318.16 ELR18358.1 - 0.071 13.3 9.0 0.032 14.4 6.6 1.6 2 0 0 2 2 2 0 FYVE-type zinc finger C1_1 PF00130.22 ELR18358.1 - 0.7 9.8 7.6 1.4 8.9 7.6 1.4 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-piccolo PF05715.13 ELR18358.1 - 6.1 7.1 11.0 14 5.9 11.0 1.6 1 1 0 1 1 1 0 Piccolo Zn-finger ubiquitin PF00240.23 ELR18359.1 - 1.5e-35 120.7 0.9 5e-14 51.8 0.0 4.4 4 0 0 4 4 4 3 Ubiquitin family PARP PF00644.20 ELR18359.1 - 8.2e-33 113.6 0.7 8.2e-33 113.6 0.7 2.9 2 1 0 2 2 2 1 Poly(ADP-ribose) polymerase catalytic domain PARP_reg PF02877.14 ELR18359.1 - 4.2e-17 62.5 0.1 9.1e-17 61.4 0.1 1.6 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase, regulatory domain Rad60-SLD PF11976.8 ELR18359.1 - 7.3e-12 44.9 0.0 0.0011 18.8 0.0 3.7 3 0 0 3 3 3 2 Ubiquitin-2 like Rad60 SUMO-like WGR PF05406.15 ELR18359.1 - 4.5e-08 33.1 0.7 1.3e-07 31.6 0.7 1.8 1 0 0 1 1 1 1 WGR domain BRCT_2 PF16589.5 ELR18359.1 - 0.002 18.5 0.0 0.0052 17.2 0.0 1.8 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain DUF2407 PF10302.9 ELR18359.1 - 0.0031 18.0 0.6 0.84 10.2 0.1 2.9 2 0 0 2 2 2 1 DUF2407 ubiquitin-like domain Rad60-SLD_2 PF13881.6 ELR18359.1 - 0.009 16.1 0.0 8 6.6 0.0 2.7 2 0 0 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like RTT107_BRCT_5 PF16770.5 ELR18359.1 - 0.022 14.6 0.0 0.065 13.1 0.0 1.8 1 0 0 1 1 1 0 Regulator of Ty1 transposition protein 107 BRCT domain BRCT PF00533.26 ELR18359.1 - 0.16 12.3 0.0 0.46 10.9 0.0 1.7 1 0 0 1 1 1 0 BRCA1 C Terminus (BRCT) domain MaoC_dehydrat_N PF13452.6 ELR18359.1 - 0.17 12.0 0.4 11 6.1 0.0 3.1 3 0 0 3 3 3 0 N-terminal half of MaoC dehydratase Nucleoporin_FG2 PF15967.5 ELR18359.1 - 3.4 6.1 71.7 0.011 14.4 47.9 2.5 2 0 0 2 2 2 0 Nucleoporin FG repeated region Peptidase_S30 PF01577.16 ELR18359.1 - 8.3 5.9 11.3 20 4.7 11.3 1.6 1 0 0 1 1 1 0 Potyvirus P1 protease ABC2_membrane PF01061.24 ELR18360.1 - 1.3e-44 152.2 13.9 1.3e-44 152.2 13.9 1.6 2 0 0 2 2 2 1 ABC-2 type transporter ABC_tran PF00005.27 ELR18360.1 - 3.7e-29 102.0 0.0 5.9e-29 101.3 0.0 1.3 1 0 0 1 1 1 1 ABC transporter RsgA_GTPase PF03193.16 ELR18360.1 - 7.7e-06 25.9 0.2 1.4e-05 25.1 0.2 1.3 1 0 0 1 1 1 1 RsgA GTPase AAA_21 PF13304.6 ELR18360.1 - 0.0002 21.3 1.2 0.24 11.2 0.4 2.4 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_25 PF13481.6 ELR18360.1 - 0.00058 19.5 0.0 0.0023 17.5 0.0 2.0 2 0 0 2 2 2 1 AAA domain ABC2_membrane_2 PF12679.7 ELR18360.1 - 0.0011 18.3 4.1 0.0011 18.3 4.1 1.4 2 0 0 2 2 2 1 ABC-2 family transporter protein ABC2_membrane_3 PF12698.7 ELR18360.1 - 0.0031 16.7 16.5 0.0031 16.7 16.5 1.5 1 1 0 1 1 1 1 ABC-2 family transporter protein AAA_16 PF13191.6 ELR18360.1 - 0.0072 16.7 0.0 0.015 15.7 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain AAA_29 PF13555.6 ELR18360.1 - 0.0075 16.0 0.0 0.015 15.0 0.0 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_22 PF13401.6 ELR18360.1 - 0.0081 16.4 0.1 0.051 13.8 0.1 2.1 2 1 0 2 2 2 1 AAA domain cobW PF02492.19 ELR18360.1 - 0.01 15.4 0.0 0.019 14.6 0.0 1.4 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA_23 PF13476.6 ELR18360.1 - 0.015 15.9 3.6 0.021 15.3 1.3 2.2 1 1 1 2 2 2 0 AAA domain SMC_N PF02463.19 ELR18360.1 - 0.015 14.7 0.0 3.2 7.1 0.0 2.2 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain AAA_28 PF13521.6 ELR18360.1 - 0.029 14.6 0.1 0.093 13.0 0.1 1.8 2 0 0 2 2 2 0 AAA domain AAA_18 PF13238.6 ELR18360.1 - 0.047 14.2 0.0 0.1 13.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain MMR_HSR1 PF01926.23 ELR18360.1 - 0.066 13.3 0.1 0.14 12.3 0.1 1.5 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_24 PF13479.6 ELR18360.1 - 0.095 12.4 0.0 0.19 11.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 ELR18360.1 - 0.13 12.2 0.1 0.27 11.1 0.1 1.5 1 0 0 1 1 1 0 NACHT domain AAA_30 PF13604.6 ELR18360.1 - 0.18 11.5 0.4 0.32 10.7 0.4 1.3 1 0 0 1 1 1 0 AAA domain Pkinase_Tyr PF07714.17 ELR18361.1 - 1.6e-97 325.8 0.0 7e-64 215.6 0.0 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 ELR18361.1 - 2.2e-88 296.1 0.0 1.5e-57 195.0 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Guanylate_cyc PF00211.20 ELR18361.1 - 7.8e-12 45.2 0.0 1.5e-10 41.0 0.0 2.2 1 1 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain APH PF01636.23 ELR18361.1 - 1.3e-08 35.1 0.0 9.4e-06 25.7 0.0 2.4 2 0 0 2 2 2 2 Phosphotransferase enzyme family Kinase-like PF14531.6 ELR18361.1 - 3.8e-06 26.4 0.0 0.022 14.1 0.0 2.2 2 0 0 2 2 2 2 Kinase-like Haspin_kinase PF12330.8 ELR18361.1 - 0.00015 20.8 0.0 0.064 12.2 0.0 2.3 2 0 0 2 2 2 2 Haspin like kinase domain Kdo PF06293.14 ELR18361.1 - 0.00068 19.0 0.0 0.56 9.5 0.0 2.4 2 0 0 2 2 2 2 Lipopolysaccharide kinase (Kdo/WaaP) family Seadorna_VP7 PF07387.11 ELR18361.1 - 0.0055 15.8 0.3 0.035 13.2 0.0 2.0 2 0 0 2 2 2 1 Seadornavirus VP7 SSP160 PF06933.11 ELR18361.1 - 6.2 4.9 12.0 9.1 4.3 12.0 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 RVT_2 PF07727.14 ELR18363.1 - 3.7e-60 203.6 0.0 4.2e-60 203.4 0.0 1.0 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DcpS_C PF11969.8 ELR18364.1 - 0.22 12.0 5.2 5.7 7.5 2.4 2.1 1 1 1 2 2 2 0 Scavenger mRNA decapping enzyme C-term binding NCD3G PF07562.14 ELR18366.1 - 0.19 11.7 5.8 0.12 12.3 3.3 2.0 2 0 0 2 2 2 0 Nine Cysteines Domain of family 3 GPCR Tubulin PF00091.25 ELR18368.1 - 1.5e-27 97.1 0.0 2e-27 96.7 0.0 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain F-box-like PF12937.7 ELR18368.1 - 4.7e-05 23.2 0.2 0.00014 21.7 0.2 1.8 1 0 0 1 1 1 1 F-box-like Tubulin_3 PF14881.6 ELR18368.1 - 9.2e-05 22.2 0.0 0.00017 21.3 0.0 1.4 1 0 0 1 1 1 1 Tubulin domain F-box PF00646.33 ELR18368.1 - 0.00027 20.7 0.0 0.0006 19.6 0.0 1.5 1 0 0 1 1 1 1 F-box domain RVT_2 PF07727.14 ELR18371.1 - 2.3e-13 50.3 0.0 3.6e-13 49.7 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) COesterase PF00135.28 ELR18374.1 - 1.8e-06 27.2 0.1 1.9e-06 27.0 0.1 1.0 1 0 0 1 1 1 1 Carboxylesterase family Pkinase_Tyr PF07714.17 ELR18375.1 - 7.4e-102 340.1 0.0 9.7e-59 198.7 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 ELR18375.1 - 1.9e-90 302.8 0.0 3.9e-55 187.1 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Kinase-like PF14531.6 ELR18375.1 - 1.6e-08 34.2 0.0 0.00024 20.5 0.0 2.2 2 0 0 2 2 2 2 Kinase-like PBP_like_2 PF12849.7 ELR18375.1 - 3.5e-07 30.2 0.1 4.8e-07 29.7 0.1 1.2 1 0 0 1 1 1 1 PBP superfamily domain APH PF01636.23 ELR18375.1 - 6.8e-06 26.2 1.9 0.0025 17.8 0.1 3.1 2 1 1 3 3 3 1 Phosphotransferase enzyme family EGF_2 PF07974.13 ELR18375.1 - 8.3e-06 26.1 7.7 1.6e-05 25.2 7.7 1.5 1 0 0 1 1 1 1 EGF-like domain Kdo PF06293.14 ELR18375.1 - 2.5e-05 23.8 0.0 0.0033 16.8 0.0 2.3 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 ELR18375.1 - 0.00035 20.2 0.2 0.093 12.3 0.0 2.2 2 0 0 2 2 2 2 RIO1 family FTA2 PF13095.6 ELR18375.1 - 0.00069 19.3 0.0 0.26 10.9 0.0 3.0 3 0 0 3 3 3 1 Kinetochore Sim4 complex subunit FTA2 Pkinase_fungal PF17667.1 ELR18375.1 - 0.0049 15.7 0.0 0.099 11.4 0.0 2.1 2 0 0 2 2 2 1 Fungal protein kinase Haspin_kinase PF12330.8 ELR18375.1 - 0.017 14.1 0.0 2 7.3 0.0 2.5 2 1 0 2 2 2 0 Haspin like kinase domain I-EGF_1 PF18372.1 ELR18375.1 - 0.12 12.5 4.7 0.26 11.4 4.7 1.5 1 0 0 1 1 1 0 Integrin beta epidermal growth factor like domain 1 hEGF PF12661.7 ELR18375.1 - 0.13 13.0 5.2 0.32 11.7 5.2 1.7 1 0 0 1 1 1 0 Human growth factor-like EGF EGF PF00008.27 ELR18375.1 - 0.27 11.6 3.6 0.57 10.5 3.6 1.6 1 0 0 1 1 1 0 EGF-like domain SKG6 PF08693.10 ELR18375.1 - 0.3 10.5 2.8 0.79 9.2 2.8 1.8 1 0 0 1 1 1 0 Transmembrane alpha-helix domain Toxin_29 PF08116.11 ELR18376.1 - 0.0012 18.8 0.4 0.0026 17.7 0.4 1.6 1 0 0 1 1 1 1 PhTx neurotoxin family Dickkopf_N PF04706.12 ELR18376.1 - 0.055 14.0 3.7 0.1 13.1 3.7 1.4 1 0 0 1 1 1 0 Dickkopf N-terminal cysteine-rich region Lustrin_cystein PF14625.6 ELR18376.1 - 4.8 7.6 8.8 1.4 9.4 5.3 1.9 2 1 0 2 2 2 0 Lustrin, cysteine-rich repeated domain WAP PF00095.21 ELR18376.1 - 8 7.0 10.4 14 6.2 10.2 1.7 1 1 0 1 1 1 0 WAP-type (Whey Acidic Protein) 'four-disulfide core' Rubredoxin_2 PF18073.1 ELR18378.1 - 0.021 14.5 3.5 0.045 13.5 3.5 1.6 1 0 0 1 1 1 0 Rubredoxin metal binding domain DUF3716 PF12511.8 ELR18378.1 - 0.023 14.7 0.6 0.039 14.0 0.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3716) Zn_ribbon_SprT PF17283.2 ELR18378.1 - 7.2 6.6 8.3 2.5 8.1 2.2 2.6 2 1 0 2 2 2 0 SprT-like zinc ribbon domain Chorion_3 PF05387.11 ELR18379.1 - 0.51 9.9 5.1 0.68 9.5 5.1 1.1 1 0 0 1 1 1 0 Chorion family 3 EXS PF03124.14 ELR18380.1 - 2e-61 208.2 34.0 3e-61 207.6 34.0 1.2 1 0 0 1 1 1 1 EXS family SPX PF03105.19 ELR18380.1 - 1.7e-25 90.8 29.8 2e-15 57.6 4.8 3.8 1 1 3 4 4 4 3 SPX domain eIF-3_zeta PF05091.12 ELR18380.1 - 0.2 10.6 2.8 0.32 9.9 2.8 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) zf-LYAR PF08790.11 ELR18381.1 - 3.6e-15 55.5 4.7 3.9e-13 49.1 1.1 2.6 2 0 0 2 2 2 2 LYAR-type C2HC zinc finger RE_HaeII PF09554.10 ELR18381.1 - 0.00054 19.3 0.7 0.00085 18.7 0.7 1.3 1 0 0 1 1 1 1 HaeII restriction endonuclease VIR_N PF15912.5 ELR18381.1 - 0.032 13.8 19.7 0.05 13.2 19.7 1.2 1 0 0 1 1 1 0 Virilizer, N-terminal Sgf11 PF08209.11 ELR18381.1 - 0.085 12.4 2.3 4.1 7.1 0.6 2.3 1 1 1 2 2 2 0 Sgf11 (transcriptional regulation protein) Caldesmon PF02029.15 ELR18381.1 - 0.14 10.9 47.7 0.17 10.6 47.7 1.0 1 0 0 1 1 1 0 Caldesmon DUF966 PF06136.13 ELR18381.1 - 0.35 10.5 23.2 0.43 10.2 23.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF966) Presenilin PF01080.17 ELR18381.1 - 0.46 9.2 25.7 0.57 8.9 25.7 1.3 1 0 0 1 1 1 0 Presenilin BAF1_ABF1 PF04684.13 ELR18381.1 - 0.88 8.6 31.1 1.1 8.2 31.1 1.0 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor Hid1 PF12722.7 ELR18381.1 - 1.5 6.8 25.6 1.8 6.6 25.6 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein DUF2981 PF11200.8 ELR18381.1 - 4.1 7.1 7.7 5.5 6.6 7.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2981) DUF4778 PF16008.5 ELR18381.1 - 4.2 7.3 21.8 6.3 6.8 21.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4778) Menin PF05053.13 ELR18381.1 - 4.7 5.5 22.0 5.8 5.2 22.0 1.0 1 0 0 1 1 1 0 Menin SOBP PF15279.6 ELR18381.1 - 8.2 6.9 16.9 11 6.6 16.9 1.2 1 0 0 1 1 1 0 Sine oculis-binding protein Penicil_amidase PF01804.18 ELR18382.1 - 2.1e-109 367.4 0.0 4.9e-109 366.2 0.0 1.5 1 1 0 1 1 1 1 Penicillin amidase HemX PF04375.14 ELR18382.1 - 0.12 11.7 0.0 0.16 11.2 0.0 1.2 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase DUF5414 PF17435.2 ELR18382.1 - 0.16 11.6 0.0 0.32 10.7 0.0 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5414) CDC45 PF02724.14 ELR18383.1 - 1.4 7.1 7.4 1.5 7.1 7.4 1.0 1 0 0 1 1 1 0 CDC45-like protein U79_P34 PF03064.16 ELR18383.1 - 3.5 6.9 9.9 4.3 6.6 9.9 1.3 1 0 0 1 1 1 0 HSV U79 / HCMV P34 LRR_4 PF12799.7 ELR18385.1 - 0.0014 19.0 8.1 2.7 8.5 1.2 7.1 7 1 1 8 8 8 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 ELR18385.1 - 0.0021 17.8 8.1 1 9.2 0.0 5.9 4 2 1 5 5 5 3 Leucine rich repeat LRR_4 PF12799.7 ELR18386.1 - 3.5e-05 24.1 18.4 1.2 9.6 0.0 5.9 3 3 5 8 8 8 5 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 ELR18386.1 - 0.00052 19.9 13.3 4.6 7.5 0.0 7.3 8 0 0 8 8 8 2 Leucine Rich repeat FNIP PF05725.12 ELR18386.1 - 0.0091 16.1 1.2 21 5.4 0.2 4.5 4 1 0 4 4 4 2 FNIP Repeat LRR_8 PF13855.6 ELR18386.1 - 0.015 15.0 18.9 0.32 10.8 0.5 5.4 4 2 2 6 6 6 0 Leucine rich repeat LRR_1 PF00560.33 ELR18386.1 - 0.62 10.8 15.0 21 6.2 0.9 6.8 6 2 0 6 6 6 0 Leucine Rich Repeat DUF4246 PF14033.6 ELR18387.1 - 5.7e-65 220.2 0.0 2e-33 116.2 0.0 2.5 1 1 1 2 2 2 2 Protein of unknown function (DUF4246) 2OG-FeII_Oxy_5 PF13759.6 ELR18387.1 - 0.00027 21.3 0.3 0.00082 19.7 0.0 1.9 2 0 0 2 2 2 1 Putative 2OG-Fe(II) oxygenase Retrotran_gag_2 PF14223.6 ELR18388.1 - 0.049 13.3 0.1 0.12 12.0 0.0 1.6 2 0 0 2 2 2 0 gag-polypeptide of LTR copia-type RVT_2 PF07727.14 ELR18389.1 - 1.8e-26 93.3 0.0 7.5e-26 91.2 0.0 1.7 1 1 1 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) NHL PF01436.21 ELR18391.1 - 1.1e-08 34.7 3.9 4.1e-05 23.4 0.4 2.3 2 0 0 2 2 2 2 NHL repeat LRR_6 PF13516.6 ELR18393.1 - 0.00024 20.9 5.5 77 3.7 0.0 7.7 9 0 0 9 9 9 0 Leucine Rich repeat LRR_4 PF12799.7 ELR18393.1 - 0.00028 21.2 11.6 5.5 7.5 0.2 6.9 4 3 3 7 7 7 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 ELR18393.1 - 0.0051 16.6 13.6 0.025 14.3 1.4 5.6 4 3 2 6 6 6 1 Leucine rich repeat LRR_1 PF00560.33 ELR18393.1 - 0.018 15.5 5.8 1.1e+02 4.0 0.0 6.7 6 2 0 6 6 6 0 Leucine Rich Repeat FNIP PF05725.12 ELR18393.1 - 0.045 13.9 6.7 4.4 7.6 0.2 4.7 5 0 0 5 5 5 0 FNIP Repeat F-box PF00646.33 ELR18393.1 - 0.046 13.6 2.9 0.12 12.3 0.5 2.7 2 0 0 2 2 2 0 F-box domain 4HBT_2 PF13279.6 ELR18394.1 - 2.3e-21 76.5 0.0 2.9e-21 76.2 0.0 1.1 1 0 0 1 1 1 1 Thioesterase-like superfamily 4HBT PF03061.22 ELR18394.1 - 0.00027 21.2 0.0 0.00042 20.6 0.0 1.3 1 0 0 1 1 1 1 Thioesterase superfamily IBR PF01485.21 ELR18397.1 - 1e-08 35.2 1.1 1e-08 35.2 1.1 1.9 2 0 0 2 2 2 1 IBR domain, a half RING-finger domain CUE PF02845.16 ELR18398.1 - 6.7e-05 22.5 0.1 0.0001 21.9 0.1 1.2 1 0 0 1 1 1 1 CUE domain PPR_2 PF13041.6 ELR18399.1 - 7.8e-41 138.1 6.6 9.9e-12 44.9 0.1 9.8 4 2 6 10 10 10 6 PPR repeat family PPR_3 PF13812.6 ELR18399.1 - 7.3e-36 122.1 0.1 2e-10 40.6 0.0 8.9 7 2 2 9 9 9 6 Pentatricopeptide repeat domain PPR_long PF17177.4 ELR18399.1 - 4.3e-28 98.2 0.1 4.6e-09 35.9 0.0 4.8 3 2 1 4 4 4 4 Pentacotripeptide-repeat region of PRORP PPR PF01535.20 ELR18399.1 - 4.7e-23 79.8 0.6 0.00037 20.5 0.0 8.2 8 0 0 8 8 8 4 PPR repeat PPR_1 PF12854.7 ELR18399.1 - 3e-15 55.6 1.4 0.00012 21.7 0.0 8.0 9 0 0 9 9 9 3 PPR repeat ATP13 PF12921.7 ELR18399.1 - 0.063 13.1 0.0 3.7 7.4 0.0 2.7 2 0 0 2 2 2 0 Mitochondrial ATPase expression GTP_EFTU PF00009.27 ELR18400.1 - 1.5e-19 70.3 0.1 1.9e-19 70.0 0.1 1.1 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 ELR18402.1 - 7.4e-42 142.2 0.0 1.7e-41 141.1 0.0 1.6 2 0 0 2 2 2 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 ELR18402.1 - 1.8e-16 60.3 0.6 4.8e-16 58.9 0.6 1.8 1 0 0 1 1 1 1 Elongation factor Tu domain 2 GTP_EFTU PF00009.27 ELR18402.1 - 1.7e-12 47.3 0.0 3.1e-12 46.4 0.0 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D4 PF14578.6 ELR18402.1 - 0.01 15.7 0.9 0.019 14.8 0.2 1.7 2 0 0 2 2 2 0 Elongation factor Tu domain 4 Semialdhyde_dhC PF02774.18 ELR18402.1 - 0.025 14.6 0.2 0.072 13.2 0.1 1.8 1 1 1 2 2 2 0 Semialdehyde dehydrogenase, dimerisation domain Tyr-DNA_phospho PF06087.12 ELR18403.1 - 3.7e-55 187.5 0.0 1e-53 182.8 0.0 2.0 1 1 0 1 1 1 1 Tyrosyl-DNA phosphodiesterase PLDc_2 PF13091.6 ELR18403.1 - 0.00075 19.4 0.0 0.51 10.2 0.0 2.3 2 0 0 2 2 2 2 PLD-like domain DUF4551 PF15087.6 ELR18403.1 - 0.18 10.6 3.3 0.26 10.1 3.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) Dicty_REP PF05086.12 ELR18403.1 - 0.68 7.9 8.5 0.89 7.4 8.5 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Raftlin PF15250.6 ELR18403.1 - 0.86 8.3 4.5 1.2 7.8 4.5 1.1 1 0 0 1 1 1 0 Raftlin DUF3439 PF11921.8 ELR18403.1 - 1.2 9.1 7.7 1.4 8.9 4.4 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3439) SWI-SNF_Ssr4 PF08549.10 ELR18403.1 - 2.7 6.5 8.9 3.7 6.1 8.9 1.1 1 0 0 1 1 1 0 Fungal domain of unknown function (DUF1750) FAM199X PF15814.5 ELR18403.1 - 3.8 6.5 12.3 5.9 5.9 12.3 1.3 1 0 0 1 1 1 0 Protein family FAM199X Hamartin PF04388.12 ELR18403.1 - 5.8 5.5 10.5 8 5.0 10.5 1.1 1 0 0 1 1 1 0 Hamartin protein RsgA_GTPase PF03193.16 ELR18404.1 - 0.012 15.5 0.1 0.04 13.8 0.0 1.7 1 1 1 2 2 2 0 RsgA GTPase AAA_16 PF13191.6 ELR18404.1 - 0.02 15.3 0.1 0.073 13.5 0.0 1.8 1 1 1 2 2 2 0 AAA ATPase domain AAA_29 PF13555.6 ELR18404.1 - 0.026 14.3 0.0 0.061 13.1 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain Ras PF00071.22 ELR18404.1 - 0.03 13.9 0.0 0.044 13.4 0.0 1.3 1 0 0 1 1 1 0 Ras family AAA_22 PF13401.6 ELR18404.1 - 0.093 13.0 0.0 0.2 12.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain MMR_HSR1 PF01926.23 ELR18404.1 - 0.1 12.7 0.0 0.46 10.6 0.0 2.0 2 1 1 3 3 3 0 50S ribosome-binding GTPase Roc PF08477.13 ELR18404.1 - 0.14 12.4 0.0 0.25 11.6 0.0 1.4 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase AAA_24 PF13479.6 ELR18404.1 - 0.22 11.2 0.0 0.39 10.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain RPN6_C_helix PF18503.1 ELR18404.1 - 0.3 10.9 0.5 0.73 9.6 0.2 1.9 2 0 0 2 2 2 0 26S proteasome subunit RPN6 C-terminal helix domain Pkinase_Tyr PF07714.17 ELR18405.1 - 9.1e-114 379.1 0.0 2.8e-59 200.5 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 ELR18405.1 - 4.2e-92 308.2 0.0 5.8e-46 157.0 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain PBP_like_2 PF12849.7 ELR18405.1 - 3.3e-16 59.8 0.0 1.7e-08 34.5 0.0 2.3 2 0 0 2 2 2 2 PBP superfamily domain APH PF01636.23 ELR18405.1 - 4.7e-05 23.4 0.2 0.28 11.1 0.0 2.7 2 0 0 2 2 2 2 Phosphotransferase enzyme family Guanylate_cyc PF00211.20 ELR18405.1 - 0.00026 20.7 0.0 0.082 12.5 0.0 2.3 2 0 0 2 2 2 2 Adenylate and Guanylate cyclase catalytic domain Kdo PF06293.14 ELR18405.1 - 0.036 13.4 0.0 0.36 10.1 0.0 2.1 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family WHIM1 PF15612.6 ELR18405.1 - 0.095 12.3 0.0 0.37 10.4 0.0 2.1 1 0 0 1 1 1 0 WSTF, HB1, Itc1p, MBD9 motif 1 Kinase-like PF14531.6 ELR18405.1 - 0.14 11.4 0.0 0.31 10.3 0.0 1.5 2 0 0 2 2 2 0 Kinase-like DUF5054 PF16477.5 ELR18406.1 - 8.2e-45 153.8 0.0 2.2e-44 152.4 0.0 1.6 1 1 0 1 1 1 1 Domain of unknown function (DUF5054) GGACT PF06094.12 ELR18408.1 - 4.2e-07 30.6 0.1 1.1e-06 29.2 0.0 1.7 2 0 0 2 2 2 1 Gamma-glutamyl cyclotransferase, AIG2-like AIG2_2 PF13772.6 ELR18408.1 - 7.1e-05 23.1 0.0 0.00014 22.2 0.0 1.5 1 0 0 1 1 1 1 AIG2-like family Rap_GAP PF02145.15 ELR18409.1 - 4e-57 192.8 0.0 2.1e-56 190.4 0.0 2.1 2 1 0 2 2 2 1 Rap/ran-GAP Ras PF00071.22 ELR18409.1 - 2.4e-26 92.3 0.0 4.2e-26 91.5 0.0 1.4 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR18409.1 - 2.3e-05 24.6 0.0 8.5e-05 22.8 0.0 2.0 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR18409.1 - 0.00017 21.1 0.0 0.00033 20.1 0.0 1.5 1 0 0 1 1 1 1 ADP-ribosylation factor family Ecl1 PF12855.7 ELR18409.1 - 0.22 12.7 24.5 1.8 9.7 0.2 2.7 2 0 0 2 2 2 0 ECL1/2/3 zinc binding proteins Brix PF04427.18 ELR18410.1 - 2.5e-42 145.2 2.0 4.6e-42 144.3 2.0 1.4 1 0 0 1 1 1 1 Brix domain C2 PF00168.30 ELR18411.1 - 0.00028 21.1 0.0 0.00028 21.1 0.0 2.8 3 0 0 3 3 3 1 C2 domain PH PF00169.29 ELR18412.1 - 1.3e-13 51.4 0.0 2.6e-13 50.4 0.0 1.4 1 0 0 1 1 1 1 PH domain LIM PF00412.22 ELR18412.1 - 8.3e-07 29.2 5.2 8.3e-07 29.2 5.2 2.6 3 0 0 3 3 3 1 LIM domain DZR PF12773.7 ELR18412.1 - 0.016 15.3 17.2 0.036 14.1 1.4 3.3 2 1 0 2 2 2 0 Double zinc ribbon PH_11 PF15413.6 ELR18412.1 - 0.12 12.8 1.7 1 9.8 1.7 2.3 1 1 0 1 1 1 0 Pleckstrin homology domain zf-ribbon_3 PF13248.6 ELR18412.1 - 0.5 9.9 12.7 3 7.4 0.1 3.9 3 1 0 3 3 3 0 zinc-ribbon domain UPF0547 PF10571.9 ELR18412.1 - 9.6 6.4 8.7 0.27 11.3 0.4 2.8 3 0 0 3 3 3 0 Uncharacterised protein family UPF0547 PI-PLC-C1 PF16670.5 ELR18413.1 - 0.19 10.8 0.0 0.29 10.2 0.0 1.3 1 0 0 1 1 1 0 Phosphoinositide phospholipase C, Ca2+-dependent UQ_con PF00179.26 ELR18414.1 - 4.9e-11 42.4 0.0 1.1e-10 41.3 0.0 1.6 1 1 0 1 1 1 1 Ubiquitin-conjugating enzyme MetallophosC PF16370.5 ELR18414.1 - 0.03 14.6 0.4 0.059 13.6 0.0 1.7 2 0 0 2 2 2 0 C terminal of Calcineurin-like phosphoesterase Prok-E2_A PF14457.6 ELR18414.1 - 0.059 13.0 0.0 0.1 12.2 0.0 1.3 1 0 0 1 1 1 0 Prokaryotic E2 family A tRNA_synt_1c_R2 PF04557.15 ELR18414.1 - 0.2 12.6 7.1 0.32 12.0 7.1 1.3 1 0 0 1 1 1 0 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2 Roc PF08477.13 ELR18415.1 - 2.3e-13 50.4 0.0 2.7e-12 46.9 0.0 2.3 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 ELR18415.1 - 5.4e-12 45.6 0.0 6.5e-10 38.8 0.0 2.2 2 0 0 2 2 2 2 Ras family GRDP-like PF07173.12 ELR18415.1 - 2.1e-10 41.4 1.0 1.4e-06 29.0 0.3 2.9 3 0 0 3 3 3 2 Glycine-rich domain-containing protein-like Gtr1_RagA PF04670.12 ELR18415.1 - 0.00057 19.3 0.0 0.00094 18.6 0.0 1.3 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 ELR18415.1 - 0.14 12.2 0.0 0.25 11.4 0.0 1.4 1 0 0 1 1 1 0 50S ribosome-binding GTPase Peptidase_C1 PF00112.23 ELR18416.1 - 1.2e-67 228.2 0.2 1.5e-67 227.8 0.2 1.1 1 0 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.12 ELR18416.1 - 1.1e-11 45.0 0.1 1.6e-11 44.5 0.1 1.3 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Peptidase_C1_2 PF03051.15 ELR18416.1 - 0.0021 16.9 0.6 0.35 9.6 0.1 2.1 2 0 0 2 2 2 2 Peptidase C1-like family DUF3140 PF11338.8 ELR18417.1 - 0.015 15.7 1.6 0.067 13.6 1.6 2.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3140) Methyltransf_23 PF13489.6 ELR18419.1 - 5.5e-06 26.3 0.0 7.4e-06 25.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ELR18419.1 - 0.00023 21.9 0.0 0.00049 20.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ELR18419.1 - 0.0013 18.5 0.0 0.0027 17.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ELR18419.1 - 0.0017 19.0 0.0 0.086 13.6 0.0 2.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ELR18419.1 - 0.015 16.0 0.4 0.36 11.5 0.0 2.6 2 1 0 2 2 2 0 Methyltransferase domain DUF2236 PF09995.9 ELR18420.1 - 1.3e-26 94.2 0.1 1.6e-17 64.5 0.0 2.2 2 0 0 2 2 2 2 Uncharacterized protein conserved in bacteria (DUF2236) DNA_pol3_finger PF17657.1 ELR18420.1 - 0.035 13.4 0.0 0.061 12.7 0.0 1.3 1 0 0 1 1 1 0 Bacterial DNA polymerase III alpha subunit finger domain DMAP_binding PF06464.11 ELR18420.1 - 0.2 12.5 4.9 3.3 8.5 0.9 2.3 2 0 0 2 2 2 0 DMAP1-binding Domain DUF3245 PF11595.8 ELR18420.1 - 4.4 7.8 8.7 6.5 7.2 2.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3245) Bromodomain PF00439.25 ELR18421.1 - 1.7e-18 66.4 0.0 3e-18 65.6 0.0 1.4 1 0 0 1 1 1 1 Bromodomain Antimicrobial10 PF08105.11 ELR18422.1 - 0.087 12.9 1.6 0.13 12.4 0.1 1.9 1 1 1 2 2 2 0 Metchnikowin family S1-P1_nuclease PF02265.16 ELR18423.1 - 9.5e-61 205.8 0.0 1.1e-60 205.6 0.0 1.0 1 0 0 1 1 1 1 S1/P1 Nuclease DNA_ligase_aden PF01653.18 ELR18424.1 - 1.3e-79 267.6 0.0 1.7e-79 267.2 0.0 1.2 1 0 0 1 1 1 1 NAD-dependent DNA ligase adenylation domain DNA_ligase_OB PF03120.16 ELR18424.1 - 5.2e-27 93.5 0.4 1.1e-26 92.5 0.4 1.6 1 0 0 1 1 1 1 NAD-dependent DNA ligase OB-fold domain HHH_2 PF12826.7 ELR18424.1 - 1.6e-20 73.0 0.0 4.3e-20 71.6 0.0 1.8 1 0 0 1 1 1 1 Helix-hairpin-helix motif HHH_5 PF14520.6 ELR18424.1 - 2.7e-07 31.1 0.1 0.00033 21.2 0.0 2.7 2 0 0 2 2 2 2 Helix-hairpin-helix domain BRCT PF00533.26 ELR18424.1 - 8.4e-07 29.3 0.0 1.7e-06 28.3 0.0 1.5 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain PTCB-BRCT PF12738.7 ELR18424.1 - 0.00018 21.3 0.0 0.00054 19.9 0.0 1.8 1 0 0 1 1 1 1 twin BRCT domain DNA_ligase_A_M PF01068.21 ELR18424.1 - 0.094 12.3 0.0 0.16 11.6 0.0 1.4 1 0 0 1 1 1 0 ATP dependent DNA ligase domain Ribosomal_L11_N PF03946.14 ELR18425.1 - 6.6e-05 22.7 0.0 0.00012 21.8 0.0 1.5 1 0 0 1 1 1 1 Ribosomal protein L11, N-terminal domain Ribosomal_L11 PF00298.19 ELR18425.1 - 7.2e-05 23.2 0.9 0.00012 22.5 0.0 1.9 2 1 0 2 2 2 1 Ribosomal protein L11, RNA binding domain RCC1 PF00415.18 ELR18426.1 - 7.3e-08 32.9 0.5 0.044 14.4 0.0 3.3 2 1 0 2 2 2 2 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 ELR18426.1 - 0.00085 19.1 7.8 0.072 12.9 0.2 2.6 3 0 0 3 3 3 2 Regulator of chromosome condensation (RCC1) repeat Y_phosphatase PF00102.27 ELR18427.1 - 2.1e-58 197.7 0.4 3.8e-58 196.8 0.4 1.5 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Rap1_C PF11626.8 ELR18427.1 - 0.11 12.6 0.0 0.37 10.9 0.0 2.0 1 1 0 1 1 1 0 TRF2-interacting telomeric protein/Rap1 - C terminal domain UQ_con PF00179.26 ELR18428.1 - 1.8e-22 79.5 0.0 3e-22 78.8 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme SR-25 PF10500.9 ELR18428.1 - 0.0094 15.6 5.2 0.013 15.1 5.2 1.3 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein SRP-alpha_N PF04086.13 ELR18428.1 - 0.33 10.8 11.7 0.45 10.4 11.7 1.1 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal Lectin_legB PF00139.19 ELR18429.1 - 9.7e-22 77.7 0.0 1.5e-21 77.1 0.0 1.2 1 0 0 1 1 1 1 Legume lectin domain Bact_lectin PF18483.1 ELR18429.1 - 2e-20 73.7 0.0 3e-20 73.1 0.0 1.2 1 0 0 1 1 1 1 Bacterial lectin Transglut_core PF01841.19 ELR18429.1 - 3.6e-15 56.4 1.6 9.3e-15 55.1 1.6 1.7 1 0 0 1 1 1 1 Transglutaminase-like superfamily Rad4 PF03835.15 ELR18429.1 - 2e-11 43.8 3.0 3.9e-11 42.8 3.0 1.4 1 0 0 1 1 1 1 Rad4 transglutaminase-like domain Lectin_leg-like PF03388.13 ELR18429.1 - 2.2e-06 27.2 0.0 1.3e-05 24.7 0.0 2.0 1 1 0 1 1 1 1 Legume-like lectin family PAW PF04721.17 ELR18429.1 - 0.0038 17.0 0.1 0.0073 16.1 0.1 1.5 1 0 0 1 1 1 1 PNGase C-terminal domain, mannose-binding module PAW Desulfoferrod_N PF06397.12 ELR18429.1 - 0.051 13.2 0.1 0.051 13.2 0.1 1.7 2 0 0 2 2 2 0 Desulfoferrodoxin, N-terminal domain DUF2336 PF10098.9 ELR18429.1 - 2.7 7.4 12.0 0.064 12.7 3.7 2.1 2 0 0 2 2 2 0 Uncharacterised protein conserved in bacteria (DUF2336) Phospholip_B PF04916.13 ELR18430.1 - 5e-158 527.0 0.1 5.6e-158 526.8 0.1 1.0 1 0 0 1 1 1 1 Phospholipase B Rhomboid PF01694.22 ELR18431.1 - 1.9e-23 83.1 3.6 3e-23 82.5 3.6 1.3 1 0 0 1 1 1 1 Rhomboid family DUF1751 PF08551.10 ELR18431.1 - 0.0011 19.5 0.3 0.0028 18.2 0.3 1.6 1 0 0 1 1 1 1 Eukaryotic integral membrane protein (DUF1751) DUF1576 PF07613.11 ELR18431.1 - 0.025 14.1 0.7 0.043 13.3 0.7 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1576) zf-C3HC4_3 PF13920.6 ELR18432.1 - 6.3e-07 29.2 8.7 6.3e-07 29.2 8.7 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ELR18432.1 - 0.0012 18.8 11.0 0.0028 17.6 7.3 2.3 2 0 0 2 2 2 1 zinc-RING finger domain Prok-RING_4 PF14447.6 ELR18432.1 - 0.026 14.4 9.0 0.026 14.4 9.0 2.2 2 0 0 2 2 2 0 Prokaryotic RING finger family 4 zf-RING_2 PF13639.6 ELR18432.1 - 0.4 11.1 12.8 0.11 12.8 7.9 2.3 2 0 0 2 2 2 0 Ring finger domain zf-C3HC4_4 PF15227.6 ELR18432.1 - 0.57 10.4 9.2 0.49 10.6 4.3 2.4 2 0 0 2 2 2 0 zinc finger of C3HC4-type, RING PRIMA1 PF16101.5 ELR18432.1 - 1.5 8.9 5.7 1.9 8.6 1.9 2.3 2 0 0 2 2 2 0 Proline-rich membrane anchor 1 zf-RING_UBOX PF13445.6 ELR18432.1 - 3.2 7.8 9.9 1.8 8.7 6.3 2.3 2 0 0 2 2 2 0 RING-type zinc-finger FYVE PF01363.21 ELR18433.1 - 7.1e-20 70.9 8.0 9.2e-20 70.6 8.0 1.2 1 0 0 1 1 1 1 FYVE zinc finger zf_C2HC_14 PF18574.1 ELR18433.1 - 0.00081 19.1 2.1 0.0018 18.0 2.1 1.6 1 0 0 1 1 1 1 C2HC Zing finger domain FYVE_2 PF02318.16 ELR18433.1 - 0.00093 19.4 7.9 0.0015 18.8 7.9 1.3 1 1 0 1 1 1 1 FYVE-type zinc finger UNC-79 PF14776.6 ELR18433.1 - 0.6 8.8 5.0 0.72 8.5 5.0 1.0 1 0 0 1 1 1 0 Cation-channel complex subunit UNC-79 EF-hand_5 PF13202.6 ELR18434.1 - 0.022 14.2 0.0 0.048 13.2 0.0 1.5 1 0 0 1 1 1 0 EF hand EF-hand_1 PF00036.32 ELR18434.1 - 0.067 12.8 0.0 0.14 11.8 0.0 1.5 1 0 0 1 1 1 0 EF hand RhoGEF PF00621.20 ELR18435.1 - 1.1e-43 149.6 0.0 1.6e-43 149.0 0.0 1.3 1 0 0 1 1 1 1 RhoGEF domain PH_10 PF15411.6 ELR18435.1 - 0.0084 16.4 0.1 0.017 15.4 0.1 1.5 1 0 0 1 1 1 1 Pleckstrin homology domain PH_16 PF17838.1 ELR18435.1 - 0.039 13.8 0.0 0.08 12.8 0.0 1.4 1 0 0 1 1 1 0 PH domain AT_hook PF02178.19 ELR18437.1 - 0.02 14.7 3.6 0.047 13.6 3.6 1.7 1 0 0 1 1 1 0 AT hook motif RIC3 PF15361.6 ELR18437.1 - 2.2 8.6 4.4 4.2 7.8 3.5 1.9 1 1 1 2 2 2 0 Resistance to inhibitors of cholinesterase homologue 3 RAP1 PF07218.11 ELR18438.1 - 0.51 8.6 6.6 0.51 8.6 6.6 1.0 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) MAP65_ASE1 PF03999.12 ELR18438.1 - 8.6 4.9 6.9 9.8 4.7 6.9 1.0 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) Metallophos PF00149.28 ELR18440.1 - 8.3e-05 23.2 0.0 0.0002 21.9 0.0 1.6 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 ELR18440.1 - 0.013 15.7 0.0 0.16 12.1 0.0 2.2 1 1 0 1 1 1 0 Calcineurin-like phosphoesterase superfamily domain PGA_cap PF09587.10 ELR18440.1 - 0.033 13.6 0.3 0.6 9.5 0.1 2.0 1 1 1 2 2 2 0 Bacterial capsule synthesis protein PGA_cap Tautomerase PF01361.21 ELR18440.1 - 0.05 13.5 0.0 0.12 12.4 0.0 1.6 1 0 0 1 1 1 0 Tautomerase enzyme hemP PF10636.9 ELR18440.1 - 0.1 12.4 0.0 0.18 11.6 0.0 1.4 1 0 0 1 1 1 0 Hemin uptake protein hemP CAP_N PF01213.19 ELR18440.1 - 0.6 9.5 4.4 1 8.8 4.4 1.3 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal KxDL PF10241.9 ELR18441.1 - 2.2e-16 59.9 2.0 3.9e-16 59.1 2.0 1.3 1 0 0 1 1 1 1 Uncharacterized conserved protein DUF4743 PF15916.5 ELR18441.1 - 0.025 14.6 0.6 0.077 13.0 0.6 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4743) Tweety PF04906.13 ELR18441.1 - 0.051 12.2 0.1 0.07 11.8 0.1 1.1 1 0 0 1 1 1 0 Tweety CorA PF01544.18 ELR18441.1 - 0.14 11.5 0.4 0.2 10.9 0.4 1.2 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein Nop16 PF09420.10 ELR18441.1 - 3.8 7.5 16.0 8.2 6.4 16.0 1.5 1 0 0 1 1 1 0 Ribosome biogenesis protein Nop16 Mito_carr PF00153.27 ELR18443.1 - 8.9e-18 64.0 2.3 6.9e-08 32.3 0.0 3.5 3 1 0 3 3 3 3 Mitochondrial carrier protein PH PF00169.29 ELR18444.1 - 4.7e-20 72.1 0.2 1.2e-10 41.8 0.0 2.8 2 0 0 2 2 2 2 PH domain PH_11 PF15413.6 ELR18444.1 - 8.2e-06 26.2 0.2 0.023 15.1 0.1 2.7 2 0 0 2 2 2 2 Pleckstrin homology domain PH_8 PF15409.6 ELR18444.1 - 6.4e-05 23.2 0.2 0.072 13.4 0.0 2.4 2 0 0 2 2 2 2 Pleckstrin homology domain DUF4452 PF14618.6 ELR18444.1 - 0.0037 17.2 4.3 0.0037 17.2 4.3 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF4452) PH_3 PF14593.6 ELR18444.1 - 0.0089 16.1 0.0 0.036 14.2 0.0 2.0 2 0 0 2 2 2 1 PH domain LRR_6 PF13516.6 ELR18444.1 - 0.021 14.8 3.1 12 6.2 0.1 3.9 4 0 0 4 4 4 0 Leucine Rich repeat LRR_1 PF00560.33 ELR18444.1 - 0.076 13.6 2.1 63 4.7 0.1 4.1 3 0 0 3 3 3 0 Leucine Rich Repeat F-box-like PF12937.7 ELR18445.1 - 1.6e-06 27.9 0.3 3.2e-06 26.9 0.3 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ELR18445.1 - 2e-05 24.3 0.0 4.3e-05 23.3 0.0 1.6 1 0 0 1 1 1 1 F-box domain UCH PF00443.29 ELR18446.1 - 3.6e-36 125.0 0.0 4.7e-36 124.6 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 ELR18446.1 - 5.5e-11 42.6 0.0 0.00026 20.7 0.0 2.1 2 0 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase USP7_C2 PF14533.6 ELR18446.1 - 0.0027 17.4 0.0 0.0042 16.8 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-specific protease C-terminal HypA PF01155.19 ELR18446.1 - 0.44 10.6 0.1 0.44 10.6 0.1 2.7 3 0 0 3 3 3 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA RNA_POL_M_15KD PF02150.16 ELR18446.1 - 0.56 10.1 3.2 17 5.4 0.0 3.2 3 0 0 3 3 3 0 RNA polymerases M/15 Kd subunit U-box PF04564.15 ELR18447.1 - 0.00016 21.8 0.1 0.053 13.7 0.1 2.4 1 1 0 1 1 1 1 U-box domain TMEM239 PF15841.5 ELR18447.1 - 0.031 14.2 0.9 0.054 13.4 0.9 1.3 1 0 0 1 1 1 0 Transmembrane protein 239 family ADH_N_2 PF16884.5 ELR18448.1 - 7.3e-31 106.3 0.0 1.5e-30 105.3 0.0 1.5 1 0 0 1 1 1 1 N-terminal domain of oxidoreductase ADH_zinc_N PF00107.26 ELR18448.1 - 4.5e-21 75.2 0.0 6.7e-21 74.6 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 ELR18448.1 - 5.8e-15 56.5 0.0 8.6e-15 56.0 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase WD40 PF00400.32 ELR18449.1 - 8e-10 39.2 8.7 7.2e-05 23.5 0.1 5.0 5 0 0 5 5 5 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ELR18449.1 - 1.9e-05 24.9 0.2 0.0095 16.2 0.0 2.8 2 0 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ELR18449.1 - 0.00045 19.0 0.0 0.00079 18.2 0.0 1.5 1 1 0 1 1 1 1 Nucleoporin Nup120/160 SH3_16 PF18348.1 ELR18449.1 - 0.013 15.2 3.5 0.093 12.5 0.1 2.5 2 0 0 2 2 2 0 Bacterial dipeptidyl-peptidase Sh3 domain CDtoxinA PF03498.14 ELR18449.1 - 0.055 13.1 0.1 2.4 7.7 0.0 2.5 3 0 0 3 3 3 0 Cytolethal distending toxin A/C domain Scm3 PF10384.9 ELR18449.1 - 0.094 12.5 0.1 0.27 11.0 0.1 1.7 1 0 0 1 1 1 0 Centromere protein Scm3 Ank_2 PF12796.7 ELR18450.1 - 1.3e-56 189.1 12.1 3.5e-17 62.8 0.7 4.2 1 1 4 5 5 5 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ELR18450.1 - 1.7e-40 136.9 5.3 6.9e-11 42.4 0.3 5.5 3 2 3 6 6 6 6 Ankyrin repeats (many copies) Ank PF00023.30 ELR18450.1 - 3.7e-37 125.2 8.1 2.1e-05 24.7 0.1 7.0 7 0 0 7 7 7 6 Ankyrin repeat Ank_5 PF13857.6 ELR18450.1 - 3e-34 116.6 15.9 9.6e-09 35.3 0.1 5.9 3 1 4 7 7 7 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 ELR18450.1 - 2.1e-30 101.4 5.9 0.00035 20.8 0.1 8.0 8 0 0 8 8 8 6 Ankyrin repeat BTB PF00651.31 ELR18451.1 - 2.7e-33 114.5 0.0 1.1e-16 61.0 0.0 3.7 4 0 0 4 4 4 3 BTB/POZ domain Kelch_2 PF07646.15 ELR18451.1 - 7.1e-28 95.5 2.4 1e-07 31.6 0.0 7.4 7 0 0 7 7 7 4 Kelch motif Kelch_3 PF13415.6 ELR18451.1 - 5.2e-25 87.2 2.2 1.6e-05 25.1 0.0 6.6 6 0 0 6 6 6 4 Galactose oxidase, central domain Kelch_5 PF13854.6 ELR18451.1 - 1.6e-24 85.4 4.6 7.2e-09 35.4 0.0 6.6 6 0 0 6 6 6 5 Kelch motif Kelch_4 PF13418.6 ELR18451.1 - 3.2e-23 81.5 3.7 1.7e-05 24.7 0.0 6.9 6 1 1 7 7 7 4 Galactose oxidase, central domain SPRY PF00622.28 ELR18451.1 - 1.8e-22 79.7 0.2 3.1e-22 78.9 0.2 1.4 1 0 0 1 1 1 1 SPRY domain Kelch_6 PF13964.6 ELR18451.1 - 3.2e-21 74.8 1.6 1.1e-06 28.7 0.0 6.3 6 0 0 6 6 6 4 Kelch motif Kelch_1 PF01344.25 ELR18451.1 - 2.2e-12 46.3 13.7 0.00015 21.2 0.0 5.6 7 0 0 7 7 7 3 Kelch motif Neuralized PF07177.12 ELR18451.1 - 0.022 14.8 0.0 0.13 12.2 0.0 2.3 2 1 0 2 2 2 0 Neuralized DUF4148 PF13663.6 ELR18452.1 - 0.13 12.4 0.4 0.26 11.5 0.4 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4148) Glyco_tran_WbsX PF14307.6 ELR18453.1 - 8.1e-53 180.1 0.0 3.9e-29 102.2 0.0 2.2 2 0 0 2 2 2 2 Glycosyltransferase WbsX Ank PF00023.30 ELR18454.1 - 3.2e-22 77.9 2.7 1e-07 32.1 0.1 3.6 3 0 0 3 3 3 3 Ankyrin repeat Ank_2 PF12796.7 ELR18454.1 - 2.1e-20 73.1 0.7 6.1e-15 55.6 0.3 2.3 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ELR18454.1 - 4e-20 71.9 3.7 1.3e-09 38.4 0.1 3.6 1 1 3 4 4 4 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 ELR18454.1 - 2e-18 64.5 0.4 0.00011 22.3 0.0 4.0 4 0 0 4 4 4 3 Ankyrin repeat Ank_5 PF13857.6 ELR18454.1 - 2.2e-17 62.9 0.7 7.1e-08 32.6 0.1 3.3 2 1 1 3 3 3 3 Ankyrin repeats (many copies) zf-C3HC4_3 PF13920.6 ELR18454.1 - 8.9e-07 28.7 10.2 1.3e-06 28.1 10.2 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 ELR18454.1 - 0.31 10.9 10.5 0.56 10.1 10.5 1.4 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 DUF1501 PF07394.12 ELR18454.1 - 0.58 9.1 2.7 0.75 8.8 2.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1501) zf-RING_5 PF14634.6 ELR18454.1 - 0.92 9.5 12.0 1.6 8.8 12.0 1.4 1 0 0 1 1 1 0 zinc-RING finger domain AAA PF00004.29 ELR18455.1 - 3.4e-42 144.0 0.0 5.7e-42 143.3 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 ELR18455.1 - 1.5e-10 40.7 0.1 3.7e-10 39.4 0.1 1.7 1 0 0 1 1 1 1 AAA+ lid domain Prot_ATP_ID_OB PF16450.5 ELR18455.1 - 2.5e-09 36.9 0.1 6.3e-09 35.7 0.1 1.7 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain AAA_16 PF13191.6 ELR18455.1 - 3.8e-07 30.6 0.0 0.00025 21.5 0.0 2.7 2 1 1 3 3 3 1 AAA ATPase domain AAA_2 PF07724.14 ELR18455.1 - 2.8e-06 27.5 0.0 7e-06 26.3 0.0 1.7 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_5 PF07728.14 ELR18455.1 - 3.8e-06 26.9 0.1 7.8e-05 22.7 0.1 2.6 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) RuvB_N PF05496.12 ELR18455.1 - 1.3e-05 25.0 0.0 3e-05 23.8 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 ELR18455.1 - 9e-05 22.8 0.1 0.0099 16.1 0.0 2.6 1 1 1 2 2 2 1 AAA domain DUF815 PF05673.13 ELR18455.1 - 0.00055 19.2 0.0 0.0011 18.1 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF815) IstB_IS21 PF01695.17 ELR18455.1 - 0.00091 19.0 0.0 0.002 17.9 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein Sigma54_activat PF00158.26 ELR18455.1 - 0.0014 18.3 0.1 0.0045 16.7 0.1 1.9 1 1 0 1 1 1 1 Sigma-54 interaction domain AAA_7 PF12775.7 ELR18455.1 - 0.0015 18.0 0.0 0.0039 16.7 0.0 1.7 1 1 0 1 1 1 1 P-loop containing dynein motor region RNA_helicase PF00910.22 ELR18455.1 - 0.0016 18.8 0.0 0.0039 17.6 0.0 1.7 1 0 0 1 1 1 1 RNA helicase AAA_33 PF13671.6 ELR18455.1 - 0.003 17.7 0.0 0.015 15.5 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_24 PF13479.6 ELR18455.1 - 0.0034 17.1 0.0 0.035 13.8 0.0 2.3 2 0 0 2 2 2 1 AAA domain TIP49 PF06068.13 ELR18455.1 - 0.0047 16.2 0.0 0.0097 15.1 0.0 1.5 1 0 0 1 1 1 1 TIP49 P-loop domain Mg_chelatase PF01078.21 ELR18455.1 - 0.0047 16.3 0.0 0.0097 15.3 0.0 1.5 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI TsaE PF02367.17 ELR18455.1 - 0.0054 16.7 0.0 0.0098 15.9 0.0 1.4 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE Parvo_NS1 PF01057.17 ELR18455.1 - 0.0075 15.4 0.0 0.013 14.6 0.0 1.3 1 0 0 1 1 1 1 Parvovirus non-structural protein NS1 AAA_3 PF07726.11 ELR18455.1 - 0.0099 15.7 0.0 0.022 14.6 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_14 PF13173.6 ELR18455.1 - 0.019 15.0 0.0 0.041 13.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain PhoH PF02562.16 ELR18455.1 - 0.02 14.3 0.0 0.038 13.5 0.0 1.4 1 0 0 1 1 1 0 PhoH-like protein AAA_18 PF13238.6 ELR18455.1 - 0.021 15.4 0.1 0.086 13.4 0.0 2.1 2 1 0 2 2 2 0 AAA domain AAA_30 PF13604.6 ELR18455.1 - 0.025 14.3 0.0 0.072 12.8 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.6 ELR18455.1 - 0.027 14.7 0.0 0.07 13.4 0.0 1.7 2 0 0 2 2 1 0 AAA domain AAA_25 PF13481.6 ELR18455.1 - 0.027 14.0 0.1 0.087 12.4 0.0 1.8 2 0 0 2 2 2 0 AAA domain ATPase PF06745.13 ELR18455.1 - 0.048 13.0 1.0 0.12 11.6 0.0 2.1 2 1 1 3 3 3 0 KaiC AAA_11 PF13086.6 ELR18455.1 - 0.05 13.4 0.4 0.24 11.2 0.0 2.0 2 0 0 2 2 2 0 AAA domain ABC_tran PF00005.27 ELR18455.1 - 0.068 13.7 0.0 0.26 11.8 0.0 2.0 2 0 0 2 2 2 0 ABC transporter AAA_19 PF13245.6 ELR18455.1 - 0.099 13.0 0.0 0.22 11.8 0.0 1.7 1 0 0 1 1 1 0 AAA domain Sigma54_activ_2 PF14532.6 ELR18455.1 - 0.17 12.0 0.0 0.47 10.6 0.0 1.7 1 0 0 1 1 1 0 Sigma-54 interaction domain Prot_ATP_OB_N PF17758.1 ELR18455.1 - 0.17 11.5 0.1 0.46 10.2 0.0 1.7 2 0 0 2 2 1 0 Proteasomal ATPase OB N-terminal domain Acyl-CoA_dh_N PF02771.16 ELR18456.1 - 1.4e-31 109.5 0.0 2e-31 109.0 0.0 1.2 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.19 ELR18456.1 - 5.7e-25 87.3 0.0 8.9e-25 86.7 0.0 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain PHM7_cyt PF14703.6 ELR18457.1 - 0.023 14.9 2.8 0.056 13.7 2.8 1.6 1 0 0 1 1 1 0 Cytosolic domain of 10TM putative phosphate transporter CENP-B_dimeris PF09026.10 ELR18457.1 - 0.035 14.5 10.1 0.45 10.9 5.3 2.6 2 0 0 2 2 2 0 Centromere protein B dimerisation domain FAM176 PF14851.6 ELR18457.1 - 0.23 11.1 11.4 2.2 7.9 8.9 2.4 2 0 0 2 2 2 0 FAM176 family FAM177 PF14774.6 ELR18457.1 - 0.58 10.5 6.7 8.9 6.7 4.2 2.6 2 0 0 2 2 2 0 FAM177 family Radial_spoke PF04712.12 ELR18457.1 - 2.2 7.1 15.0 0.96 8.3 9.7 2.1 2 0 0 2 2 2 0 Radial spokehead-like protein BSP_II PF05432.11 ELR18457.1 - 2.4 7.8 16.7 0.036 13.8 7.6 2.0 2 0 0 2 2 2 0 Bone sialoprotein II (BSP-II) Peptidase_S30 PF01577.16 ELR18457.1 - 4.2 6.9 6.0 7 6.2 6.0 1.3 1 0 0 1 1 1 0 Potyvirus P1 protease PTPRCAP PF15713.5 ELR18457.1 - 4.3 7.6 13.7 5.4 7.3 8.5 2.5 2 0 0 2 2 2 0 Protein tyrosine phosphatase receptor type C-associated DNA_pol_phi PF04931.13 ELR18457.1 - 8.7 4.3 14.3 3.5 5.6 9.2 2.0 2 0 0 2 2 2 0 DNA polymerase phi Phage_holin_3_6 PF07332.11 ELR18459.1 - 0.18 11.9 1.9 9.7 6.3 0.2 2.3 2 0 0 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III DUF1664 PF07889.12 ELR18460.1 - 0.059 13.4 0.6 0.22 11.6 0.7 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) IFT20 PF14931.6 ELR18460.1 - 0.064 13.4 0.8 0.1 12.8 0.8 1.3 1 0 0 1 1 1 0 Intraflagellar transport complex B, subunit 20 DUF349 PF03993.12 ELR18460.1 - 0.089 13.1 0.1 0.19 12.1 0.1 1.6 1 0 0 1 1 1 0 Domain of Unknown Function (DUF349) Ribonuc_L-PSP PF01042.21 ELR18462.1 - 0.037 14.0 0.0 0.053 13.5 0.0 1.4 1 0 0 1 1 1 0 Endoribonuclease L-PSP YdiH PF15930.5 ELR18464.1 - 0.14 12.4 0.0 0.19 11.9 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function AAA_16 PF13191.6 ELR18466.1 - 0.00085 19.7 1.2 0.0026 18.2 1.2 2.2 1 1 0 1 1 1 1 AAA ATPase domain AAA PF00004.29 ELR18466.1 - 0.024 15.1 0.0 0.061 13.8 0.0 1.7 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) DUF87 PF01935.17 ELR18466.1 - 0.045 13.8 0.0 0.066 13.3 0.0 1.6 1 1 0 1 1 1 0 Helicase HerA, central domain AAA_5 PF07728.14 ELR18466.1 - 0.067 13.2 0.0 0.71 9.9 0.0 2.3 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) Torsin PF06309.11 ELR18466.1 - 0.096 12.8 0.0 0.19 11.9 0.0 1.4 1 0 0 1 1 1 0 Torsin AAA_22 PF13401.6 ELR18466.1 - 0.11 12.7 0.0 0.25 11.6 0.0 1.7 1 0 0 1 1 1 0 AAA domain SP_C-Propep PF08999.10 ELR18467.1 - 0.14 12.0 2.5 0.27 11.0 2.5 1.4 1 0 0 1 1 1 0 Surfactant protein C, N terminal propeptide Herpes_US9 PF06072.11 ELR18467.1 - 0.27 11.1 3.3 12 5.9 1.2 2.6 2 0 0 2 2 2 0 Alphaherpesvirus tegument protein US9 SR-25 PF10500.9 ELR18468.1 - 0.34 10.5 7.5 0.67 9.5 7.5 1.4 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein MatC_N PF07158.11 ELR18469.1 - 0.082 12.9 1.5 0.45 10.5 1.3 2.1 1 1 0 1 1 1 0 Dicarboxylate carrier protein MatC N-terminus DUF5082 PF16888.5 ELR18470.1 - 0.0063 16.8 1.4 0.0063 16.8 1.4 3.0 2 1 0 3 3 3 1 Domain of unknown function (DUF5082) DUF713 PF05218.14 ELR18470.1 - 0.029 14.1 2.1 0.41 10.4 0.4 2.6 1 1 0 2 2 2 0 Protein of unknown function (DUF713) DUF3106 PF11304.8 ELR18470.1 - 0.045 14.2 5.6 3.2 8.3 1.2 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF3106) bact-PGI_C PF10432.9 ELR18470.1 - 0.1 12.6 0.0 0.24 11.5 0.0 1.7 1 0 0 1 1 1 0 Bacterial phospho-glucose isomerase C-terminal SIS domain ATG16 PF08614.11 ELR18470.1 - 0.38 11.0 11.5 2.4 8.3 7.6 2.2 2 0 0 2 2 2 0 Autophagy protein 16 (ATG16) Imm68 PF15583.6 ELR18470.1 - 0.44 10.7 3.7 1.2 9.3 0.4 2.8 1 1 2 3 3 3 0 Immunity protein 68 Fib_alpha PF08702.10 ELR18470.1 - 5.3 7.2 10.6 0.12 12.5 2.4 2.3 3 0 0 3 3 3 0 Fibrinogen alpha/beta chain family CENP-H PF05837.12 ELR18470.1 - 8.9 6.8 13.8 51 4.3 0.1 3.6 3 1 0 3 3 3 0 Centromere protein H (CENP-H) Pkinase PF00069.25 ELR18471.1 - 5.2e-53 180.1 0.0 7.3e-53 179.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR18471.1 - 7e-52 176.3 0.0 9.3e-52 175.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase PIP49_C PF12260.8 ELR18471.1 - 0.0008 19.1 1.1 0.0011 18.7 0.0 1.7 2 0 0 2 2 2 1 Protein-kinase domain of FAM69 Kdo PF06293.14 ELR18471.1 - 0.0021 17.4 0.1 0.0039 16.6 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 ELR18471.1 - 0.083 12.2 0.0 0.14 11.5 0.0 1.2 1 0 0 1 1 1 0 Kinase-like Barttin PF15462.6 ELR18471.1 - 1.5 8.6 6.6 2.7 7.7 6.6 1.5 1 0 0 1 1 1 0 Bartter syndrome, infantile, with sensorineural deafness (Barttin) CDC45 PF02724.14 ELR18471.1 - 6.1 5.0 20.3 9 4.4 20.3 1.1 1 0 0 1 1 1 0 CDC45-like protein F-box PF00646.33 ELR18472.1 - 8.4e-09 35.1 0.0 1.6e-08 34.2 0.0 1.4 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 ELR18472.1 - 2.3e-08 33.8 0.8 5.1e-08 32.7 0.8 1.6 1 0 0 1 1 1 1 F-box-like Ras PF00071.22 ELR18472.1 - 4.7e-06 26.3 0.0 2.6e-05 23.9 0.0 2.0 1 1 1 2 2 2 1 Ras family SAP PF02037.27 ELR18473.1 - 1.1e-10 41.0 0.8 2e-10 40.2 0.8 1.5 1 0 0 1 1 1 1 SAP domain PI3K_1B_p101 PF10486.9 ELR18473.1 - 1.2 6.8 11.2 1.8 6.3 11.2 1.2 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit Thioredoxin_6 PF13848.6 ELR18474.1 - 0.048 13.6 0.0 5.9 6.8 0.0 2.3 2 0 0 2 2 2 0 Thioredoxin-like domain Thioredoxin PF00085.20 ELR18474.1 - 0.053 13.5 0.0 0.11 12.6 0.0 1.5 1 0 0 1 1 1 0 Thioredoxin DUF4174 PF13778.6 ELR18474.1 - 0.083 13.4 0.0 0.15 12.5 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4174) Acetyltransf_1 PF00583.25 ELR18475.1 - 1e-11 45.1 0.0 1.2e-11 44.8 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 ELR18475.1 - 3.9e-11 43.0 0.0 4.9e-11 42.7 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 ELR18475.1 - 1.8e-09 37.9 0.0 2.4e-09 37.5 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.7 ELR18475.1 - 9.5e-06 26.3 0.0 1.2e-05 26.0 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 ELR18475.1 - 2.1e-05 24.4 0.0 3.1e-05 23.9 0.0 1.2 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_CG PF14542.6 ELR18475.1 - 6.3e-05 23.0 0.1 0.00012 22.2 0.1 1.4 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase Acetyltransf_9 PF13527.7 ELR18475.1 - 0.002 18.2 0.3 0.014 15.4 0.1 2.1 2 1 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_13 PF13880.6 ELR18475.1 - 0.013 15.5 0.1 0.024 14.6 0.1 1.4 1 0 0 1 1 1 0 ESCO1/2 acetyl-transferase Acetyltransf_6 PF13480.7 ELR18475.1 - 0.024 14.8 0.1 0.034 14.3 0.1 1.4 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 ELR18475.1 - 0.052 13.7 0.0 0.058 13.5 0.0 1.2 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_18 PF18014.1 ELR18475.1 - 0.11 12.3 0.0 0.17 11.7 0.0 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain F-box-like PF12937.7 ELR18476.1 - 2.4e-07 30.5 0.1 4.3e-07 29.7 0.1 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ELR18476.1 - 0.0041 17.0 0.1 0.01 15.7 0.1 1.6 1 0 0 1 1 1 1 F-box domain DUF4217 PF13959.6 ELR18476.1 - 0.085 13.1 0.0 0.16 12.2 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4217) SMK-1 PF04802.15 ELR18477.1 - 0.04 13.8 0.1 0.29 10.9 0.0 2.5 2 1 1 3 3 3 0 Component of IIS longevity pathway SMK-1 TetR_C_8 PF14278.6 ELR18477.1 - 0.16 12.1 1.4 1.3 9.1 0.0 2.9 3 0 0 3 3 3 0 Transcriptional regulator C-terminal region SAP30_Sin3_bdg PF13867.6 ELR18480.1 - 8.9e-17 61.2 0.1 1.5e-16 60.5 0.1 1.3 1 0 0 1 1 1 1 Sin3 binding region of histone deacetylase complex subunit SAP30 DUF2722 PF10846.8 ELR18480.1 - 0.011 14.8 2.6 0.013 14.4 2.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Stork_head PF10264.9 ELR18480.1 - 0.071 13.3 0.0 0.11 12.7 0.0 1.2 1 0 0 1 1 1 0 Winged helix Storkhead-box1 domain DUF5473 PF17567.2 ELR18480.1 - 0.08 13.2 7.1 0.15 12.3 7.1 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5473) zf-AN1 PF01428.16 ELR18481.1 - 5e-11 42.6 2.4 5e-11 42.6 2.4 1.7 1 1 0 1 1 1 1 AN1-like Zinc finger ubiquitin PF00240.23 ELR18481.1 - 1.8e-09 37.2 0.1 3.1e-09 36.5 0.1 1.4 1 0 0 1 1 1 1 Ubiquitin family Transp_Tc5_C PF04236.15 ELR18481.1 - 7.9e-05 22.9 2.0 0.00016 22.0 2.0 1.5 1 0 0 1 1 1 1 Tc5 transposase C-terminal domain Rad60-SLD PF11976.8 ELR18481.1 - 0.0054 16.5 0.0 0.011 15.6 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Herpes_pp85 PF04637.12 ELR18481.1 - 0.066 11.6 1.9 0.08 11.3 1.9 1.1 1 0 0 1 1 1 0 Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25) MRP_L53 PF10780.9 ELR18482.1 - 0.0011 19.1 0.0 0.0024 18.0 0.0 1.6 1 0 0 1 1 1 1 39S ribosomal protein L53/MRP-L53 L51_S25_CI-B8 PF05047.16 ELR18482.1 - 0.025 14.5 0.0 0.069 13.1 0.0 1.9 1 1 1 2 2 2 0 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain HA PF03457.14 ELR18483.1 - 2.4e-07 31.0 20.2 9.5e-05 22.7 4.8 3.7 3 1 1 4 4 4 2 Helicase associated domain BTB PF00651.31 ELR18484.1 - 1.2e-10 41.6 0.0 9.5e-09 35.5 0.0 2.6 2 0 0 2 2 2 2 BTB/POZ domain MOZART1 PF12554.8 ELR18485.1 - 3.9e-22 77.8 0.1 4.5e-22 77.6 0.1 1.0 1 0 0 1 1 1 1 Mitotic-spindle organizing gamma-tubulin ring associated zf-MYND PF01753.18 ELR18486.1 - 8.4e-13 48.2 14.7 1.5e-12 47.4 14.7 1.4 1 0 0 1 1 1 1 MYND finger zf-C6H2 PF15801.5 ELR18486.1 - 0.043 14.1 5.5 0.1 12.9 5.5 1.6 1 0 0 1 1 1 0 zf-MYND-like zinc finger, mRNA-binding PHF5 PF03660.14 ELR18486.1 - 0.058 13.6 2.7 0.13 12.5 2.7 1.5 1 0 0 1 1 1 0 PHF5-like protein PBP_N PF17093.5 ELR18486.1 - 0.11 12.7 1.7 3.8 7.8 0.1 2.4 2 0 0 2 2 2 0 Penicillin-binding protein N-terminus SAYSvFN PF10260.9 ELR18487.1 - 5.9e-21 74.2 0.9 8.4e-21 73.7 0.9 1.2 1 0 0 1 1 1 1 Uncharacterized conserved domain (SAYSvFN) CCDC24 PF15669.5 ELR18487.1 - 0.018 14.9 3.1 0.8 9.5 0.0 2.1 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 24 family KleE PF17394.2 ELR18487.1 - 0.047 13.9 1.4 0.057 13.6 0.1 1.7 2 0 0 2 2 2 0 Uncharacterized KleE stable inheritance protein TrbE PF11100.8 ELR18487.1 - 2.4 8.5 6.8 15 5.9 3.6 2.2 1 1 1 2 2 2 0 Conjugal transfer protein TrbE Thioredoxin PF00085.20 ELR18488.1 - 4.2e-27 94.1 0.0 6.1e-27 93.6 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin UBX PF00789.20 ELR18488.1 - 4.7e-19 68.4 0.0 4.4e-18 65.3 0.0 2.1 2 0 0 2 2 2 1 UBX domain Thioredoxin_2 PF13098.6 ELR18488.1 - 0.00017 22.0 0.1 0.00052 20.4 0.1 1.7 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_8 PF13905.6 ELR18488.1 - 0.00021 21.6 0.0 0.00034 20.9 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin-like Thioredoxin_9 PF14595.6 ELR18488.1 - 0.026 14.3 0.0 0.038 13.8 0.0 1.1 1 0 0 1 1 1 0 Thioredoxin Thioredoxin_7 PF13899.6 ELR18488.1 - 0.12 12.6 0.0 0.2 11.9 0.0 1.4 1 0 0 1 1 1 0 Thioredoxin-like AhpC-TSA PF00578.21 ELR18488.1 - 0.14 12.0 0.0 0.24 11.3 0.0 1.3 1 0 0 1 1 1 0 AhpC/TSA family OST3_OST6 PF04756.13 ELR18488.1 - 0.27 10.6 0.0 0.38 10.1 0.0 1.1 1 0 0 1 1 1 0 OST3 / OST6 family, transporter family Arf PF00025.21 ELR18489.1 - 9.1e-54 181.5 0.0 1.2e-53 181.1 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 ELR18489.1 - 7.1e-08 32.7 0.0 1.1e-07 32.0 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 ELR18489.1 - 8.6e-08 31.9 0.0 1.1e-07 31.6 0.0 1.2 1 0 0 1 1 1 1 Ras family G-alpha PF00503.20 ELR18489.1 - 2e-05 24.0 0.0 9.1e-05 21.8 0.0 1.9 1 1 1 2 2 2 1 G-protein alpha subunit SRPRB PF09439.10 ELR18489.1 - 8.3e-05 22.1 0.0 0.00017 21.1 0.0 1.4 2 0 0 2 2 2 1 Signal recognition particle receptor beta subunit F-box PF00646.33 ELR18489.1 - 0.00011 21.9 0.3 0.00032 20.5 0.3 1.8 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 ELR18489.1 - 0.00064 19.6 0.6 0.00064 19.6 0.6 1.7 2 0 0 2 2 2 1 F-box-like Gtr1_RagA PF04670.12 ELR18489.1 - 0.0012 18.3 0.0 0.0022 17.4 0.0 1.4 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region Zeta_toxin PF06414.12 ELR18489.1 - 0.099 11.9 0.0 0.19 11.0 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin Porphobil_deam PF01379.20 ELR18490.1 - 8.4e-74 247.5 0.0 1e-73 247.2 0.0 1.1 1 0 0 1 1 1 1 Porphobilinogen deaminase, dipyromethane cofactor binding domain Porphobil_deamC PF03900.15 ELR18490.1 - 2.3e-18 66.4 0.2 4.5e-18 65.4 0.2 1.5 1 0 0 1 1 1 1 Porphobilinogen deaminase, C-terminal domain LysR_substrate PF03466.20 ELR18490.1 - 0.07 12.5 0.1 2.7 7.3 0.0 2.6 3 0 0 3 3 3 0 LysR substrate binding domain PolyA_pol PF01743.20 ELR18491.1 - 3.5e-14 53.3 0.0 5.7e-14 52.6 0.0 1.3 1 0 0 1 1 1 1 Poly A polymerase head domain PolyA_pol_RNAbd PF12627.7 ELR18491.1 - 2e-06 27.5 0.0 0.00016 21.4 0.0 2.5 2 0 0 2 2 2 2 Probable RNA and SrmB- binding site of polymerase A HATPase_c PF02518.26 ELR18492.1 - 2.6e-23 82.7 0.0 4.8e-23 81.8 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 ELR18492.1 - 6.7e-13 48.5 0.1 1.4e-12 47.4 0.1 1.6 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain GAF_3 PF13492.6 ELR18492.1 - 0.0045 17.3 0.0 0.013 15.8 0.0 1.8 2 0 0 2 2 2 1 GAF domain PAS_4 PF08448.10 ELR18492.1 - 0.0058 16.9 0.0 0.014 15.6 0.0 1.7 1 0 0 1 1 1 1 PAS fold GAF_2 PF13185.6 ELR18492.1 - 0.0067 16.7 0.0 0.013 15.8 0.0 1.5 1 0 0 1 1 1 1 GAF domain HATPase_c_3 PF13589.6 ELR18492.1 - 0.026 14.4 0.0 0.05 13.4 0.0 1.4 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 ELR18493.1 - 4e-35 120.4 0.4 2e-24 85.9 0.0 3.4 2 1 1 3 3 3 2 Response regulator receiver domain HATPase_c PF02518.26 ELR18493.1 - 1.4e-18 67.5 0.0 4e-18 65.9 0.0 1.9 1 1 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 ELR18493.1 - 3.2e-11 43.1 1.1 3.2e-11 43.1 1.1 2.3 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain PAS_4 PF08448.10 ELR18493.1 - 5.1e-11 42.8 0.0 1.2e-10 41.6 0.0 1.7 1 0 0 1 1 1 1 PAS fold PAS PF00989.25 ELR18493.1 - 9.7e-06 25.6 1.5 1.3e-05 25.2 0.1 1.9 2 0 0 2 2 2 1 PAS fold PAS_9 PF13426.7 ELR18493.1 - 0.00024 21.3 0.0 0.00053 20.2 0.0 1.6 1 0 0 1 1 1 1 PAS domain PAS_8 PF13188.7 ELR18493.1 - 0.0054 16.7 0.1 0.014 15.4 0.1 1.7 1 0 0 1 1 1 1 PAS domain Pkinase_Tyr PF07714.17 ELR18495.1 - 7.6e-128 425.2 0.0 3.4e-64 216.6 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 ELR18495.1 - 4.8e-109 363.8 0.0 5e-56 190.0 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain PBP_like_2 PF12849.7 ELR18495.1 - 1.2e-30 107.2 4.3 1.5e-15 57.6 1.2 2.4 2 0 0 2 2 2 2 PBP superfamily domain Guanylate_cyc PF00211.20 ELR18495.1 - 1e-11 44.8 0.0 8.8e-11 41.8 0.0 2.2 1 1 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain Kinase-like PF14531.6 ELR18495.1 - 6.1e-07 29.0 0.0 0.024 13.9 0.0 2.4 2 0 0 2 2 2 2 Kinase-like Pkinase_fungal PF17667.1 ELR18495.1 - 1.4e-05 24.1 0.0 0.02 13.7 0.0 2.3 2 0 0 2 2 2 2 Fungal protein kinase APH PF01636.23 ELR18495.1 - 1.6e-05 24.9 0.3 0.008 16.1 0.0 2.6 2 0 0 2 2 2 2 Phosphotransferase enzyme family FTA2 PF13095.6 ELR18495.1 - 0.00038 20.1 0.0 0.41 10.2 0.0 3.7 2 2 1 4 4 4 1 Kinetochore Sim4 complex subunit FTA2 Kdo PF06293.14 ELR18495.1 - 0.0004 19.8 0.1 0.33 10.3 0.0 2.4 2 0 0 2 2 2 2 Lipopolysaccharide kinase (Kdo/WaaP) family EGF_2 PF07974.13 ELR18495.1 - 0.00046 20.5 11.1 0.00088 19.6 11.1 1.5 1 0 0 1 1 1 1 EGF-like domain Haspin_kinase PF12330.8 ELR18495.1 - 0.0056 15.7 0.2 0.33 9.8 0.0 2.3 2 0 0 2 2 2 1 Haspin like kinase domain TMEM154 PF15102.6 ELR18495.1 - 0.013 15.4 0.0 0.04 13.8 0.0 1.8 1 0 0 1 1 1 0 TMEM154 protein family RIO1 PF01163.22 ELR18495.1 - 0.015 14.9 0.5 5.6 6.5 0.1 2.6 2 1 0 2 2 2 0 RIO1 family EGF PF00008.27 ELR18495.1 - 0.56 10.6 4.9 1.1 9.6 4.9 1.5 1 0 0 1 1 1 0 EGF-like domain hEGF PF12661.7 ELR18495.1 - 0.73 10.6 3.3 2 9.2 3.3 1.8 1 0 0 1 1 1 0 Human growth factor-like EGF Laminin_EGF PF00053.24 ELR18495.1 - 2.1 8.6 6.9 4.5 7.5 6.9 1.5 1 0 0 1 1 1 0 Laminin EGF domain VPS28 PF03997.12 ELR18496.1 - 4.1e-62 209.2 0.3 4.9e-62 209.0 0.3 1.1 1 0 0 1 1 1 1 VPS28 protein RNase_3_N PF18497.1 ELR18496.1 - 0.044 14.0 0.2 5.6 7.2 0.0 3.2 2 2 1 3 3 3 0 Ribonuclease III N-terminal domain Pkinase PF00069.25 ELR18497.1 - 2.4e-52 177.9 0.0 3.6e-52 177.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR18497.1 - 1.4e-51 175.3 0.0 1.9e-51 174.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 ELR18497.1 - 0.00041 19.8 0.2 0.00086 18.7 0.2 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 ELR18497.1 - 0.001 18.1 0.0 0.002 17.1 0.0 1.4 1 0 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 ELR18497.1 - 0.0011 19.0 0.0 0.0021 18.0 0.0 1.5 1 0 0 1 1 1 1 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 ELR18497.1 - 0.0028 16.5 0.0 0.0028 16.5 0.0 3.2 3 1 0 3 3 3 1 Fungal protein kinase adh_short PF00106.25 ELR18498.1 - 3.7e-54 183.2 0.2 4.3e-54 182.9 0.2 1.0 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ELR18498.1 - 7.5e-36 123.8 0.3 2.4e-35 122.2 0.3 1.7 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ELR18498.1 - 1.8e-09 37.8 0.3 2.7e-09 37.2 0.3 1.3 1 1 0 1 1 1 1 KR domain NAD_binding_10 PF13460.6 ELR18498.1 - 0.00062 19.7 0.1 0.0018 18.2 0.1 1.9 1 1 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 ELR18498.1 - 0.0016 17.9 0.0 0.0049 16.4 0.0 1.6 1 1 1 2 2 2 1 NAD dependent epimerase/dehydratase family DUF1776 PF08643.10 ELR18498.1 - 0.013 14.9 0.0 0.025 13.9 0.0 1.4 2 0 0 2 2 2 0 Fungal family of unknown function (DUF1776) Sacchrp_dh_NADP PF03435.18 ELR18498.1 - 0.041 14.1 0.1 0.081 13.2 0.1 1.5 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain ADH_zinc_N PF00107.26 ELR18498.1 - 0.092 12.7 0.9 0.16 12.0 0.9 1.3 1 0 0 1 1 1 0 Zinc-binding dehydrogenase Methyltransf_16 PF10294.9 ELR18499.1 - 1.6e-29 102.8 0.0 2.1e-29 102.5 0.0 1.1 1 0 0 1 1 1 1 Lysine methyltransferase Methyltransf_25 PF13649.6 ELR18499.1 - 1.5e-06 28.9 0.0 2.7e-06 28.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 ELR18499.1 - 1.6e-06 27.7 0.0 2.2e-06 27.3 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.14 ELR18499.1 - 1.8e-05 24.3 0.0 2.8e-05 23.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_23 PF13489.6 ELR18499.1 - 7.3e-05 22.7 0.0 0.00011 22.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ELR18499.1 - 0.00048 19.9 0.0 0.0007 19.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ELR18499.1 - 0.0015 19.3 0.0 0.0024 18.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Cons_hypoth95 PF03602.15 ELR18499.1 - 0.0072 16.0 0.0 0.011 15.4 0.0 1.3 1 0 0 1 1 1 1 Conserved hypothetical protein 95 Methyltransf_11 PF08241.12 ELR18499.1 - 0.022 15.4 0.1 0.045 14.4 0.1 1.5 1 1 0 1 1 1 0 Methyltransferase domain PCMT PF01135.19 ELR18499.1 - 0.054 13.2 0.0 0.07 12.9 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) TehB PF03848.14 ELR18499.1 - 0.082 12.3 0.0 0.12 11.7 0.0 1.2 1 0 0 1 1 1 0 Tellurite resistance protein TehB Ras PF00071.22 ELR18500.1 - 2.4e-51 173.5 0.2 2.9e-51 173.3 0.2 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR18500.1 - 8.6e-16 58.2 0.1 1.4e-15 57.6 0.1 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR18500.1 - 8.8e-07 28.5 0.1 1.1e-06 28.2 0.1 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 ELR18500.1 - 0.00023 21.1 1.1 0.28 11.1 0.0 2.3 2 1 0 2 2 2 2 RsgA GTPase FeoB_N PF02421.18 ELR18500.1 - 0.005 16.4 0.2 0.036 13.6 0.0 2.0 2 0 0 2 2 2 1 Ferrous iron transport protein B MMR_HSR1 PF01926.23 ELR18500.1 - 0.0099 16.0 0.0 0.017 15.2 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase ThiF PF00899.21 ELR18500.1 - 0.17 11.2 0.1 0.34 10.2 0.1 1.5 1 0 0 1 1 1 0 ThiF family BAF1_ABF1 PF04684.13 ELR18501.1 - 0.00091 18.4 0.6 0.0012 18.0 0.6 1.1 1 0 0 1 1 1 1 BAF1 / ABF1 chromatin reorganising factor TerB_C PF15615.6 ELR18501.1 - 0.87 9.9 5.2 2.7 8.3 5.2 1.9 1 0 0 1 1 1 0 TerB-C domain XRCC4 PF06632.12 ELR18501.1 - 2 7.2 12.8 4.1 6.2 12.8 1.5 1 0 0 1 1 1 0 DNA double-strand break repair and V(D)J recombination protein XRCC4 Bud13 PF09736.9 ELR18501.1 - 2.4 8.5 10.4 4 7.8 10.4 1.3 1 0 0 1 1 1 0 Pre-mRNA-splicing factor of RES complex MitMem_reg PF13012.6 ELR18503.1 - 1.7e-19 70.3 0.0 2.5e-19 69.7 0.0 1.3 1 0 0 1 1 1 1 Maintenance of mitochondrial structure and function JAB PF01398.21 ELR18503.1 - 5.7e-19 68.2 0.1 4.5e-18 65.3 0.0 2.0 2 0 0 2 2 2 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease HSP20 PF00011.21 ELR18504.1 - 9.7e-10 38.5 0.0 2.5e-09 37.2 0.0 1.8 1 1 0 1 1 1 1 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 ELR18504.1 - 4e-06 26.3 1.2 1.8e-05 24.2 0.5 2.4 2 1 0 2 2 2 1 HSP20-like domain found in ArsA TMEM144 PF07857.12 ELR18505.1 - 8.2e-113 376.8 7.1 9.5e-113 376.6 7.1 1.0 1 0 0 1 1 1 1 Transmembrane family, TMEM144 of transporters Sugar_transport PF06800.12 ELR18505.1 - 2.6e-06 27.0 4.3 2.6e-06 27.0 4.3 2.5 2 1 0 2 2 2 1 Sugar transport protein Ureide_permease PF07168.11 ELR18505.1 - 0.37 9.5 6.9 5.5 5.6 0.1 2.3 2 1 0 2 2 2 0 Ureide permease DMT_YdcZ PF04657.13 ELR18505.1 - 5.3 7.3 25.9 0.098 12.9 10.6 3.2 3 2 0 3 3 3 0 Putative inner membrane exporter, YdcZ Endotoxin_C PF03944.14 ELR18506.1 - 0.016 15.5 0.2 0.043 14.2 0.2 1.8 1 0 0 1 1 1 0 delta endotoxin Pkinase PF00069.25 ELR18507.1 - 4.6e-38 131.1 0.0 1.1e-37 129.9 0.0 1.6 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR18507.1 - 3.9e-16 59.1 0.0 7.1e-16 58.3 0.0 1.4 1 1 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 ELR18507.1 - 6.7e-05 22.9 2.2 0.21 11.5 0.0 2.9 2 2 2 4 4 4 2 Phosphotransferase enzyme family Kdo PF06293.14 ELR18507.1 - 0.096 12.0 0.1 0.22 10.8 0.0 1.6 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family Acetyltransf_1 PF00583.25 ELR18508.1 - 2.5e-16 60.0 0.0 4.2e-16 59.2 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 ELR18508.1 - 4e-09 36.5 0.1 6.9e-09 35.7 0.1 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 ELR18508.1 - 2.6e-07 30.5 0.0 5.2e-07 29.5 0.0 1.4 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_7 PF13508.7 ELR18508.1 - 3.9e-07 30.4 0.0 6.3e-07 29.7 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 ELR18508.1 - 0.012 15.6 0.0 0.021 14.9 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_13 PF13880.6 ELR18508.1 - 0.065 13.2 0.0 0.12 12.3 0.0 1.5 1 0 0 1 1 1 0 ESCO1/2 acetyl-transferase Acetyltransf_15 PF17013.5 ELR18508.1 - 0.077 12.4 0.0 0.11 12.0 0.0 1.2 1 0 0 1 1 1 0 Putative acetyl-transferase DUF3206 PF11472.8 ELR18508.1 - 0.1 12.6 0.0 0.4 10.7 0.0 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF3206) TUTF7_u4 PF16631.5 ELR18508.1 - 0.35 11.5 12.6 0.54 10.9 4.1 2.3 1 1 1 2 2 2 0 Unstructured region 4 on terminal uridylyltransferase 7 SRP-alpha_N PF04086.13 ELR18508.1 - 1.6 8.6 14.2 2 8.3 14.2 1.1 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal Mito_carr PF00153.27 ELR18509.1 - 1.9e-08 34.1 0.1 1.7e-07 31.1 0.0 2.2 2 1 0 2 2 2 1 Mitochondrial carrier protein DUF4235 PF14019.6 ELR18509.1 - 0.13 12.4 0.3 0.34 11.0 0.3 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF4235) Homeodomain PF00046.29 ELR18510.1 - 1.2e-16 60.3 0.5 1.2e-16 60.3 0.5 2.5 2 0 0 2 2 2 1 Homeodomain Homeobox_KN PF05920.11 ELR18510.1 - 0.0026 17.6 0.0 0.0083 16.0 0.0 1.9 1 0 0 1 1 1 1 Homeobox KN domain Upf2 PF04050.14 ELR18510.1 - 0.2 12.4 8.4 2.2 9.0 0.4 3.1 3 0 0 3 3 3 0 Up-frameshift suppressor 2 ABC2_membrane PF01061.24 ELR18511.1 - 4.9e-37 127.4 17.7 4.9e-37 127.4 17.7 1.6 2 0 0 2 2 2 1 ABC-2 type transporter ABC_tran PF00005.27 ELR18511.1 - 3.7e-10 40.4 0.0 6.5e-10 39.7 0.0 1.4 1 0 0 1 1 1 1 ABC transporter ABC2_membrane_3 PF12698.7 ELR18511.1 - 0.16 11.0 17.3 0.37 9.9 17.3 1.6 1 1 0 1 1 1 0 ABC-2 family transporter protein ABC2_membrane_2 PF12679.7 ELR18511.1 - 0.24 10.7 12.5 0.032 13.5 6.6 2.1 2 1 0 2 2 2 0 ABC-2 family transporter protein MORN PF02493.20 ELR18513.1 - 3.2e-40 133.7 63.1 8.8e-08 31.6 0.8 9.3 10 0 0 10 10 10 7 MORN repeat F-box-like PF12937.7 ELR18513.1 - 4e-06 26.6 0.0 6.4e-06 26.0 0.0 1.3 1 0 0 1 1 1 1 F-box-like RAP1 PF07218.11 ELR18513.1 - 0.24 9.6 3.2 0.34 9.2 3.2 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) ArfGap PF01412.18 ELR18514.1 - 1.2e-34 118.9 0.0 1.2e-34 118.9 0.0 3.9 4 0 0 4 4 4 1 Putative GTPase activating protein for Arf PH PF00169.29 ELR18514.1 - 1.5e-16 60.8 1.1 1.3e-07 32.1 0.0 3.8 2 1 0 2 2 2 2 PH domain PH_11 PF15413.6 ELR18514.1 - 0.23 11.9 0.0 0.21 12.1 0.3 5.0 5 1 0 5 5 5 0 Pleckstrin homology domain Kisspeptin PF15152.6 ELR18514.1 - 2.8 8.8 0.0 2.8 8.8 0.0 3.4 3 1 0 3 3 3 0 Kisspeptin ArfGap PF01412.18 ELR18516.1 - 3e-36 124.1 0.0 3.8e-36 123.7 0.0 1.1 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf NmrA PF05368.13 ELR18519.1 - 6.2e-56 189.6 0.3 7.5e-56 189.3 0.3 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 ELR18519.1 - 1e-14 54.8 0.5 1.8e-14 54.1 0.5 1.4 1 0 0 1 1 1 1 NAD(P)H-binding 3Beta_HSD PF01073.19 ELR18519.1 - 7.9e-06 25.1 0.1 1.6e-05 24.1 0.1 1.5 2 0 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 ELR18519.1 - 0.00026 20.5 0.1 0.0005 19.6 0.1 1.5 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family SIR2 PF02146.17 ELR18520.1 - 3.9e-18 66.0 0.0 5.2e-18 65.6 0.0 1.2 1 0 0 1 1 1 1 Sir2 family OrfB_Zn_ribbon PF07282.11 ELR18520.1 - 0.012 15.5 3.8 4.2 7.4 0.2 3.5 2 1 1 3 3 3 0 Putative transposase DNA-binding domain Zn-ribbon_8 PF09723.10 ELR18520.1 - 0.016 15.4 0.5 0.05 13.7 0.5 1.9 1 0 0 1 1 1 0 Zinc ribbon domain HTH_IclR PF09339.10 ELR18520.1 - 0.038 13.8 0.0 0.078 12.8 0.0 1.5 1 0 0 1 1 1 0 IclR helix-turn-helix domain DEP PF00610.21 ELR18520.1 - 0.18 11.9 0.1 0.88 9.7 0.0 2.2 2 1 0 2 2 2 0 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) DUF1700 PF08006.11 ELR18521.1 - 0.032 13.8 2.6 0.054 13.0 0.2 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1700) PolC_DP2 PF03833.13 ELR18521.1 - 8.1 4.2 6.1 9.9 3.9 6.1 1.0 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 SelK_SelG PF10961.8 ELR18522.1 - 0.017 15.8 3.4 0.028 15.0 3.4 1.4 1 0 0 1 1 1 0 Selenoprotein SelK_SelG DSPc PF00782.20 ELR18524.1 - 1.5e-08 34.5 0.0 0.00057 19.7 0.0 2.1 1 1 1 2 2 2 2 Dual specificity phosphatase, catalytic domain CDI PF02234.19 ELR18526.1 - 5.2e-05 23.4 0.0 0.00012 22.2 0.0 1.5 1 0 0 1 1 1 1 Cyclin-dependent kinase inhibitor SOG2 PF10428.9 ELR18526.1 - 0.0091 15.2 19.2 0.011 15.0 19.2 1.2 1 0 0 1 1 1 1 RAM signalling pathway protein Apt1 PF10351.9 ELR18526.1 - 0.086 11.7 11.3 0.099 11.5 11.3 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain ADH_zinc_N_2 PF13602.6 ELR18527.1 - 1.9e-19 71.1 0.0 9e-19 68.8 0.1 2.1 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.26 ELR18527.1 - 2.3e-10 40.6 0.0 5.1e-10 39.4 0.0 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 ELR18527.1 - 7.3e-10 38.7 0.0 3.6e-09 36.5 0.0 1.9 1 1 1 2 2 2 1 Alcohol dehydrogenase GroES-like domain DUF758 PF05527.11 ELR18528.1 - 1.2e-13 51.5 0.7 1.9e-13 50.8 0.7 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF758) PH PF00169.29 ELR18528.1 - 1.1e-10 41.9 0.0 2.6e-10 40.7 0.0 1.6 1 0 0 1 1 1 1 PH domain PH_9 PF15410.6 ELR18528.1 - 0.0036 17.7 0.1 0.046 14.1 0.1 2.3 1 1 0 1 1 1 1 Pleckstrin homology domain PH_8 PF15409.6 ELR18528.1 - 0.02 15.2 0.6 0.25 11.6 0.6 2.4 1 1 0 1 1 1 0 Pleckstrin homology domain PH_6 PF15406.6 ELR18528.1 - 0.044 14.1 0.1 0.12 12.7 0.0 1.7 2 0 0 2 2 2 0 Pleckstrin homology domain Ald_Xan_dh_C2 PF02738.18 ELR18529.1 - 1.7e-135 452.6 0.1 3e-135 451.8 0.1 1.3 1 0 0 1 1 1 1 Molybdopterin-binding domain of aldehyde dehydrogenase FAD_binding_5 PF00941.21 ELR18529.1 - 3.7e-36 124.4 0.0 7.4e-36 123.4 0.0 1.5 1 0 0 1 1 1 1 FAD binding domain in molybdopterin dehydrogenase CO_deh_flav_C PF03450.17 ELR18529.1 - 2.1e-34 117.8 0.1 5.4e-34 116.5 0.1 1.8 1 0 0 1 1 1 1 CO dehydrogenase flavoprotein C-terminal domain Ald_Xan_dh_C PF01315.22 ELR18529.1 - 3.3e-32 111.1 0.1 8.9e-32 109.7 0.1 1.8 1 0 0 1 1 1 1 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain Fer2_2 PF01799.20 ELR18529.1 - 1.7e-27 95.3 0.0 6.7e-27 93.3 0.0 2.1 2 0 0 2 2 2 1 [2Fe-2S] binding domain Fer2 PF00111.27 ELR18529.1 - 1.4e-08 34.5 0.4 3.9e-08 33.1 0.4 1.8 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain DHODB_Fe-S_bind PF10418.9 ELR18529.1 - 0.0059 16.4 1.9 0.02 14.7 1.9 1.8 1 0 0 1 1 1 1 Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B Bac_DnaA_C PF08299.11 ELR18529.1 - 0.17 12.0 0.0 0.57 10.2 0.0 1.9 1 0 0 1 1 1 0 Bacterial dnaA protein helix-turn-helix TruD PF01142.18 ELR18530.1 - 5.5e-43 147.3 0.1 6.8e-43 147.0 0.1 1.1 1 0 0 1 1 1 1 tRNA pseudouridine synthase D (TruD) Viral_helicase1 PF01443.18 ELR18531.1 - 0.065 13.0 0.3 0.094 12.4 0.2 1.5 1 1 0 1 1 1 0 Viral (Superfamily 1) RNA helicase Peptidase_S8 PF00082.22 ELR18532.1 - 5.7e-06 25.8 0.1 5.7e-06 25.8 0.1 1.5 2 0 0 2 2 2 1 Subtilase family APG17 PF04108.12 ELR18533.1 - 1.7e-16 60.4 16.8 7.1e-13 48.4 14.9 2.2 1 1 1 2 2 2 2 Autophagy protein Apg17 DUF948 PF06103.11 ELR18533.1 - 0.004 17.4 3.4 0.32 11.3 0.4 3.2 3 0 0 3 3 3 1 Bacterial protein of unknown function (DUF948) DUF2125 PF09898.9 ELR18533.1 - 0.0052 16.5 0.5 0.019 14.6 0.1 1.9 1 1 0 2 2 2 1 Uncharacterized protein conserved in bacteria (DUF2125) DUF1664 PF07889.12 ELR18533.1 - 0.014 15.4 6.3 1.2 9.2 0.3 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF1664) Dynein_C PF18199.1 ELR18533.1 - 0.019 14.2 1.5 0.04 13.1 1.5 1.4 1 0 0 1 1 1 0 Dynein heavy chain C-terminal domain NCA2 PF08637.10 ELR18533.1 - 0.051 12.7 2.9 0.097 11.8 2.9 1.4 1 0 0 1 1 1 0 ATP synthase regulation protein NCA2 Fib_alpha PF08702.10 ELR18533.1 - 0.057 13.6 8.9 0.33 11.1 4.3 2.6 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family DUF4446 PF14584.6 ELR18533.1 - 0.06 13.3 3.6 5.6 6.9 0.0 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF4446) V_ATPase_I PF01496.19 ELR18533.1 - 0.13 10.1 5.8 0.088 10.7 3.6 1.7 1 1 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF4795 PF16043.5 ELR18533.1 - 0.14 11.8 7.9 0.2 11.3 3.8 2.5 1 1 0 2 2 2 0 Domain of unknown function (DUF4795) ALIX_LYPXL_bnd PF13949.6 ELR18533.1 - 0.41 9.9 18.3 3.7 6.8 18.3 2.0 1 1 0 1 1 1 0 ALIX V-shaped domain binding to HIV Baculo_PEP_C PF04513.12 ELR18533.1 - 4.2 7.4 8.0 4.5 7.3 0.5 2.9 2 1 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus BLOC1_2 PF10046.9 ELR18533.1 - 6 7.2 8.9 20 5.6 0.5 3.7 3 2 1 4 4 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Zip PF02535.22 ELR18534.1 - 4.3e-28 98.5 15.4 9.6e-27 94.1 15.4 2.2 1 1 0 1 1 1 1 ZIP Zinc transporter DUF4407 PF14362.6 ELR18534.1 - 0.51 9.6 3.6 0.98 8.7 3.6 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF4191 PF13829.6 ELR18534.1 - 4.4 6.6 7.3 0.78 9.0 1.6 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4191) adh_short_C2 PF13561.6 ELR18535.1 - 2e-56 191.2 7.3 3.6e-56 190.3 7.3 1.3 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 ELR18535.1 - 8.6e-44 149.3 5.8 2.8e-43 147.7 5.8 1.7 1 1 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 ELR18535.1 - 5.4e-12 46.0 2.0 9.9e-12 45.1 1.8 1.5 1 1 1 2 2 2 1 KR domain SIMPL PF04402.14 ELR18536.1 - 7.8e-14 52.6 0.1 8.8e-14 52.4 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF541) Peptidase_M60_C PF18630.1 ELR18536.1 - 0.019 15.1 0.3 3.3 7.9 0.0 2.6 3 0 0 3 3 3 0 Peptidase M60 C-terminal domain Pro-kuma_activ PF09286.11 ELR18537.1 - 5.2e-31 107.9 0.0 9.1e-31 107.1 0.0 1.4 1 0 0 1 1 1 1 Pro-kumamolisin, activation domain Peptidase_S8 PF00082.22 ELR18537.1 - 0.018 14.3 0.1 0.033 13.5 0.1 1.4 1 0 0 1 1 1 0 Subtilase family Soyouz_module PF14313.6 ELR18537.1 - 0.11 12.3 0.0 0.29 10.9 0.0 1.6 1 0 0 1 1 1 0 N-terminal region of Paramyxovirinae phosphoprotein (P) 4HPAD_g_N PF18671.1 ELR18537.1 - 0.13 12.0 0.0 0.28 10.9 0.0 1.6 1 0 0 1 1 1 0 4-Hydroxyphenylacetate decarboxylase subunit gamma N-terminal BcrAD_BadFG PF01869.20 ELR18538.1 - 6.6e-47 160.2 0.1 8.7e-47 159.9 0.1 1.2 1 0 0 1 1 1 1 BadF/BadG/BcrA/BcrD ATPase family ROK PF00480.20 ELR18538.1 - 0.021 14.3 0.2 2.3 7.6 0.0 2.2 2 0 0 2 2 2 0 ROK family FGGY_N PF00370.21 ELR18538.1 - 0.024 14.2 0.0 0.043 13.4 0.0 1.4 1 0 0 1 1 1 0 FGGY family of carbohydrate kinases, N-terminal domain Peripla_BP_3 PF13377.6 ELR18538.1 - 0.079 13.3 0.0 0.89 9.9 0.0 2.3 2 0 0 2 2 2 0 Periplasmic binding protein-like domain PALP PF00291.25 ELR18539.1 - 1.4e-75 254.5 1.5 1.7e-75 254.1 1.5 1.0 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme VDE PF07137.11 ELR18540.1 - 3.5e-05 23.5 14.6 3.5e-05 23.5 14.6 1.8 1 1 1 2 2 2 1 VDE lipocalin domain F-box-like PF12937.7 ELR18541.1 - 6.9e-11 41.9 0.1 1.4e-10 40.9 0.1 1.5 1 0 0 1 1 1 1 F-box-like Cbl_N2 PF02761.14 ELR18541.1 - 7.8e-06 26.5 0.4 2.2e-05 25.1 0.2 1.8 2 0 0 2 2 2 1 CBL proto-oncogene N-terminus, EF hand-like domain F-box PF00646.33 ELR18541.1 - 0.00038 20.2 0.0 0.00084 19.2 0.0 1.5 1 0 0 1 1 1 1 F-box domain PBP1_TM PF14812.6 ELR18542.1 - 0.0094 16.3 0.7 0.016 15.6 0.7 1.3 1 0 0 1 1 1 1 Transmembrane domain of transglycosylase PBP1 at N-terminal Gram_pos_anchor PF00746.21 ELR18542.1 - 0.015 15.2 2.0 0.016 15.1 0.1 2.1 2 0 0 2 2 2 0 LPXTG cell wall anchor motif FAM176 PF14851.6 ELR18542.1 - 0.11 12.2 0.0 0.18 11.4 0.0 1.4 1 0 0 1 1 1 0 FAM176 family DNA_pol_phi PF04931.13 ELR18542.1 - 1.9 6.5 3.7 2.9 5.9 3.7 1.1 1 0 0 1 1 1 0 DNA polymerase phi NOA36 PF06524.12 ELR18542.1 - 3.8 6.8 5.4 5.6 6.2 5.4 1.1 1 0 0 1 1 1 0 NOA36 protein PH PF00169.29 ELR18543.1 - 0.00033 21.1 0.0 0.00041 20.8 0.0 1.1 1 0 0 1 1 1 1 PH domain DNA_Packaging_2 PF11123.8 ELR18544.1 - 0.097 12.9 0.0 0.11 12.7 0.0 1.1 1 0 0 1 1 1 0 DNA packaging protein TPR_7 PF13176.6 ELR18545.1 - 1.3e-05 24.9 0.0 0.27 11.3 0.0 3.0 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 ELR18545.1 - 6.5e-05 22.6 0.0 0.33 10.8 0.0 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 ELR18545.1 - 0.00032 20.6 0.0 0.85 9.9 0.0 3.1 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.6 ELR18545.1 - 0.0012 19.3 0.0 0.0028 18.1 0.0 1.6 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_8 PF13181.6 ELR18545.1 - 0.0037 17.3 0.0 1.7 9.0 0.0 2.9 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.6 ELR18545.1 - 0.036 14.4 0.0 4.7 7.6 0.0 2.6 1 1 0 2 2 2 0 Tetratricopeptide repeat Bap31 PF05529.12 ELR18545.1 - 0.067 13.0 0.1 0.13 12.1 0.1 1.4 1 0 0 1 1 1 0 Bap31/Bap29 transmembrane region ANAPC3 PF12895.7 ELR18545.1 - 0.088 13.0 0.1 0.25 11.6 0.1 1.7 1 0 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_10 PF13374.6 ELR18545.1 - 0.098 12.6 0.0 15 5.6 0.0 2.7 2 1 0 2 2 2 0 Tetratricopeptide repeat RasGEF PF00617.19 ELR18546.1 - 1.2e-47 162.4 0.1 2.3e-47 161.5 0.1 1.5 1 0 0 1 1 1 1 RasGEF domain V4R PF02830.18 ELR18546.1 - 3.8e-09 36.4 4.0 0.00038 20.4 0.2 2.9 2 1 0 2 2 2 2 V4R domain Folate_rec PF03024.14 ELR18547.1 - 0.02 14.8 3.6 0.061 13.2 3.6 1.7 1 1 0 1 1 1 0 Folate receptor family ADH_zinc_N PF00107.26 ELR18548.1 - 1.4e-33 115.6 0.9 2.3e-33 115.0 0.9 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 ELR18548.1 - 1.8e-20 74.4 0.0 3.8e-20 73.3 0.0 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 ELR18548.1 - 1.4e-12 47.4 0.3 1.1e-10 41.4 0.0 2.9 2 1 1 3 3 3 2 Alcohol dehydrogenase GroES-like domain ADH_N_2 PF16884.5 ELR18548.1 - 0.0053 16.6 1.2 0.017 15.0 0.0 2.2 2 0 0 2 2 2 1 N-terminal domain of oxidoreductase DLH PF01738.18 ELR18549.1 - 5.1e-43 147.2 0.1 8.2e-43 146.5 0.1 1.4 1 0 0 1 1 1 1 Dienelactone hydrolase family AhpC-TSA PF00578.21 ELR18549.1 - 2.2e-35 121.2 0.0 4.5e-35 120.3 0.0 1.5 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 ELR18549.1 - 2e-13 50.3 0.0 4.3e-13 49.2 0.0 1.5 1 0 0 1 1 1 1 Redoxin 1-cysPrx_C PF10417.9 ELR18549.1 - 5.6e-08 32.5 0.3 6e-06 26.0 0.1 2.5 2 0 0 2 2 2 1 C-terminal domain of 1-Cys peroxiredoxin Abhydrolase_1 PF00561.20 ELR18549.1 - 0.00016 21.4 0.1 0.00044 20.0 0.0 1.8 2 0 0 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 ELR18549.1 - 0.00044 20.9 0.2 0.0011 19.6 0.2 1.7 1 1 0 1 1 1 1 Alpha/beta hydrolase family AXE1 PF05448.12 ELR18549.1 - 0.0012 17.6 0.1 0.0019 17.0 0.1 1.2 1 0 0 1 1 1 1 Acetyl xylan esterase (AXE1) BAAT_C PF08840.11 ELR18549.1 - 0.004 17.1 1.5 0.062 13.2 0.1 3.0 1 1 2 3 3 3 1 BAAT / Acyl-CoA thioester hydrolase C terminal Abhydrolase_3 PF07859.13 ELR18549.1 - 0.0044 16.9 0.4 2.3 8.0 0.0 2.4 2 0 0 2 2 2 2 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 ELR18549.1 - 0.011 15.0 0.1 0.087 12.1 0.0 1.9 1 1 1 2 2 2 0 Serine aminopeptidase, S33 DUF4013 PF13197.6 ELR18549.1 - 0.02 14.7 4.7 0.041 13.7 4.7 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4013) SCO1-SenC PF02630.14 ELR18549.1 - 0.13 12.2 0.0 0.78 9.6 0.0 2.1 2 0 0 2 2 2 0 SCO1/SenC Peptidase_S9 PF00326.21 ELR18549.1 - 0.16 11.5 0.3 4 6.9 0.0 2.2 1 1 1 2 2 2 0 Prolyl oligopeptidase family FtsX PF02687.21 ELR18549.1 - 3.3 8.2 8.3 0.57 10.7 1.8 2.7 3 0 0 3 3 3 0 FtsX-like permease family SSP160 PF06933.11 ELR18549.1 - 3.9 5.5 13.5 5.6 5.0 13.5 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 GATase_2 PF00310.21 ELR18550.1 - 1.2e-29 103.3 0.0 1.6e-29 102.9 0.0 1.2 1 0 0 1 1 1 1 Glutamine amidotransferases class-II GATase_2 PF00310.21 ELR18551.1 - 4e-147 490.3 0.0 5.7e-147 489.8 0.0 1.2 1 0 0 1 1 1 1 Glutamine amidotransferases class-II Glu_syn_central PF04898.14 ELR18551.1 - 5.5e-87 291.8 0.0 7.9e-87 291.3 0.0 1.2 1 0 0 1 1 1 1 Glutamate synthase central domain Glu_synthase PF01645.17 ELR18551.1 - 3.1e-27 95.7 0.1 2.1e-25 89.6 0.0 2.2 2 0 0 2 2 2 2 Conserved region in glutamate synthase GATase_6 PF13522.6 ELR18551.1 - 0.096 12.9 0.0 0.31 11.2 0.0 1.8 1 0 0 1 1 1 0 Glutamine amidotransferase domain Glu_synthase PF01645.17 ELR18552.1 - 3.3e-103 345.7 0.5 5.1e-103 345.0 0.5 1.3 1 0 0 1 1 1 1 Conserved region in glutamate synthase GXGXG PF01493.19 ELR18552.1 - 3.6e-67 225.7 5.9 7e-67 224.7 5.9 1.5 1 0 0 1 1 1 1 GXGXG motif Pyr_redox_2 PF07992.14 ELR18552.1 - 2.9e-22 79.3 0.9 1.2e-16 60.9 0.0 2.4 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Fer4_20 PF14691.6 ELR18552.1 - 5.1e-21 74.5 0.3 1.2e-20 73.3 0.3 1.5 1 0 0 1 1 1 1 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster NAD_binding_8 PF13450.6 ELR18552.1 - 4.4e-08 33.2 0.0 1.3e-07 31.8 0.0 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 ELR18552.1 - 1.9e-07 31.0 0.4 0.0039 16.8 0.1 2.7 2 0 0 2 2 2 2 FAD dependent oxidoreductase Pyr_redox PF00070.27 ELR18552.1 - 5.1e-07 30.2 0.1 0.0047 17.5 0.1 3.0 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Amino_oxidase PF01593.24 ELR18552.1 - 6.9e-05 22.3 1.6 0.00011 21.7 0.0 2.2 3 0 0 3 3 3 1 Flavin containing amine oxidoreductase HI0933_like PF03486.14 ELR18552.1 - 0.0002 20.2 0.3 0.00072 18.4 0.1 2.0 2 0 0 2 2 2 1 HI0933-like protein Pyr_redox_3 PF13738.6 ELR18552.1 - 0.0012 18.1 0.3 0.16 11.2 0.1 2.7 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_7 PF13241.6 ELR18552.1 - 0.0013 19.1 0.1 1 9.8 0.0 2.6 2 0 0 2 2 2 1 Putative NAD(P)-binding FAD_oxidored PF12831.7 ELR18552.1 - 0.0034 16.8 0.1 0.0076 15.6 0.1 1.5 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_3 PF01494.19 ELR18552.1 - 0.0066 15.7 0.1 0.025 13.8 0.0 2.1 2 0 0 2 2 2 1 FAD binding domain AlaDh_PNT_C PF01262.21 ELR18552.1 - 0.0099 15.2 0.1 5.5 6.2 0.1 2.6 2 0 0 2 2 2 2 Alanine dehydrogenase/PNT, C-terminal domain Thi4 PF01946.17 ELR18552.1 - 0.023 14.0 0.0 0.071 12.3 0.0 1.8 1 0 0 1 1 1 0 Thi4 family GIDA PF01134.22 ELR18552.1 - 0.085 11.9 1.4 0.47 9.5 0.0 2.2 2 0 0 2 2 2 0 Glucose inhibited division protein A FMN_dh PF01070.18 ELR18552.1 - 0.55 9.2 10.0 0.19 10.7 4.7 2.8 4 0 0 4 4 4 0 FMN-dependent dehydrogenase NAD_binding_9 PF13454.6 ELR18552.1 - 1.8 8.5 4.4 9.1 6.3 0.1 3.2 3 0 0 3 3 3 0 FAD-NAD(P)-binding F-box-like PF12937.7 ELR18553.1 - 7.6e-09 35.3 0.3 1.5e-08 34.4 0.3 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ELR18553.1 - 0.00015 21.6 0.2 0.00034 20.4 0.0 1.7 2 0 0 2 2 2 1 F-box domain Mannosyl_trans3 PF11051.8 ELR18553.1 - 0.094 12.0 0.0 0.18 11.1 0.0 1.4 1 0 0 1 1 1 0 Mannosyltransferase putative PRA1 PF03208.19 ELR18554.1 - 0.096 12.3 0.2 0.12 12.0 0.2 1.1 1 0 0 1 1 1 0 PRA1 family protein AMP-binding PF00501.28 ELR18555.1 - 8.4e-67 225.6 0.0 1.4e-59 201.8 0.0 2.2 1 1 1 2 2 2 2 AMP-binding enzyme NAD_binding_4 PF07993.12 ELR18555.1 - 1e-57 195.3 0.0 1.6e-57 194.6 0.0 1.3 1 0 0 1 1 1 1 Male sterility protein Epimerase PF01370.21 ELR18555.1 - 8.4e-10 38.5 0.0 2.6e-09 36.9 0.0 1.7 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 ELR18555.1 - 3.5e-08 33.2 0.0 0.0014 18.1 0.0 2.1 2 0 0 2 2 2 2 GDP-mannose 4,6 dehydratase AMP-binding_C PF13193.6 ELR18555.1 - 0.00063 20.7 0.0 0.0034 18.3 0.0 2.4 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain NAD_binding_10 PF13460.6 ELR18555.1 - 0.0008 19.3 0.0 0.0052 16.7 0.0 2.4 2 1 0 2 2 2 1 NAD(P)H-binding RmlD_sub_bind PF04321.17 ELR18555.1 - 0.021 13.9 0.0 1.3 8.0 0.0 2.9 2 1 0 2 2 2 0 RmlD substrate binding domain SNARE PF05739.19 ELR18556.1 - 1.7e-05 24.7 2.4 1.7e-05 24.7 2.4 3.1 2 1 1 3 3 3 1 SNARE domain AAA_13 PF13166.6 ELR18556.1 - 0.0033 16.1 19.0 0.0095 14.6 13.5 2.0 1 1 1 2 2 2 2 AAA domain TetR_C_13 PF16925.5 ELR18556.1 - 0.031 14.2 1.6 0.41 10.6 0.1 2.4 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain DUF5345 PF17280.2 ELR18556.1 - 0.043 13.8 0.8 0.15 12.1 0.8 2.0 1 0 0 1 1 1 0 Family of unknown function (DUF5345) Fusion_gly PF00523.18 ELR18556.1 - 0.061 11.6 5.0 0.1 10.8 5.0 1.4 1 0 0 1 1 1 0 Fusion glycoprotein F0 AAA_5 PF07728.14 ELR18556.1 - 0.14 12.2 1.5 0.35 10.9 1.5 1.7 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) LOH1CR12 PF10158.9 ELR18556.1 - 0.15 12.0 9.3 0.24 11.4 4.0 2.9 1 1 0 2 2 2 0 Tumour suppressor protein T2SSF PF00482.23 ELR18556.1 - 1.2 9.1 6.6 0.18 11.7 0.5 2.6 3 0 0 3 3 3 0 Type II secretion system (T2SS), protein F Tweety PF04906.13 ELR18556.1 - 6.9 5.2 7.6 1.3 7.7 2.7 2.1 1 1 1 2 2 2 0 Tweety TBCC_N PF16752.5 ELR18556.1 - 9.2 6.7 10.9 2 8.8 1.2 2.7 1 1 0 2 2 2 0 Tubulin-specific chaperone C N-terminal domain Pkinase_Tyr PF07714.17 ELR18557.1 - 2.8e-47 161.2 0.0 3.7e-47 160.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ELR18557.1 - 7.1e-44 150.1 0.0 9.5e-44 149.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Kdo PF06293.14 ELR18557.1 - 0.0019 17.6 0.0 0.0029 17.0 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 ELR18557.1 - 0.0039 16.8 0.0 0.0078 15.8 0.0 1.4 1 0 0 1 1 1 1 RIO1 family Pkinase_fungal PF17667.1 ELR18557.1 - 0.0077 15.0 0.0 0.014 14.1 0.0 1.4 2 0 0 2 2 2 1 Fungal protein kinase APH PF01636.23 ELR18557.1 - 0.035 14.0 0.0 0.067 13.1 0.0 1.5 1 0 0 1 1 1 0 Phosphotransferase enzyme family Pkinase_Tyr PF07714.17 ELR18558.1 - 6.3e-18 65.0 0.0 8.3e-18 64.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ELR18558.1 - 7e-09 35.4 0.0 9.5e-09 35.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain BAR_3 PF16746.5 ELR18558.1 - 0.035 13.8 0.0 0.048 13.4 0.0 1.1 1 0 0 1 1 1 0 BAR domain of APPL family UCH PF00443.29 ELR18560.1 - 0.092 12.2 0.0 0.12 11.9 0.0 1.2 1 0 0 1 1 1 0 Ubiquitin carboxyl-terminal hydrolase Methyltransf_11 PF08241.12 ELR18561.1 - 3.9e-21 75.5 0.4 6.2e-21 74.8 0.1 1.5 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ELR18561.1 - 8.4e-21 74.5 0.2 1.7e-20 73.5 0.1 1.5 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ELR18561.1 - 2e-20 73.4 0.0 3.3e-20 72.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ELR18561.1 - 5e-18 65.3 0.0 6.7e-18 64.9 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 ELR18561.1 - 2.1e-14 53.7 0.0 5.6e-14 52.3 0.0 1.5 1 1 1 2 2 2 1 Methyltransferase domain Ubie_methyltran PF01209.18 ELR18561.1 - 8.5e-14 51.5 0.0 1.2e-13 50.9 0.0 1.1 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family NodS PF05401.11 ELR18561.1 - 9e-08 32.0 0.0 1.3e-07 31.4 0.0 1.1 1 0 0 1 1 1 1 Nodulation protein S (NodS) MTS PF05175.14 ELR18561.1 - 9.1e-07 28.6 0.0 2.4e-06 27.2 0.0 1.6 1 1 1 2 2 2 1 Methyltransferase small domain CMAS PF02353.20 ELR18561.1 - 3.8e-06 26.4 0.0 5.9e-06 25.8 0.0 1.3 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase PrmA PF06325.13 ELR18561.1 - 2.1e-05 24.1 0.0 3e-05 23.6 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_32 PF13679.6 ELR18561.1 - 2.7e-05 24.2 0.0 3.7e-05 23.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_9 PF08003.11 ELR18561.1 - 0.00023 20.2 0.0 0.00035 19.6 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) TehB PF03848.14 ELR18561.1 - 0.00043 19.8 0.0 0.00062 19.2 0.0 1.1 1 0 0 1 1 1 1 Tellurite resistance protein TehB MetW PF07021.12 ELR18561.1 - 0.0053 16.4 0.0 0.0089 15.6 0.0 1.3 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW Methyltransf_8 PF05148.15 ELR18561.1 - 0.006 16.5 0.0 0.046 13.6 0.0 2.0 1 1 0 1 1 1 1 Hypothetical methyltransferase N2227 PF07942.12 ELR18561.1 - 0.016 14.4 0.0 0.16 11.1 0.0 1.9 1 1 1 2 2 2 0 N2227-like protein NAS PF03059.16 ELR18561.1 - 0.017 14.5 0.0 0.024 14.0 0.0 1.1 1 0 0 1 1 1 0 Nicotianamine synthase protein DREV PF05219.12 ELR18561.1 - 0.053 12.6 0.0 0.095 11.8 0.0 1.3 1 0 0 1 1 1 0 DREV methyltransferase Methyltransf_24 PF13578.6 ELR18561.1 - 0.059 14.4 1.4 0.095 13.7 0.1 1.9 2 1 0 2 2 2 0 Methyltransferase domain AdoMet_MTase PF07757.13 ELR18561.1 - 0.063 13.6 0.0 0.12 12.7 0.0 1.4 1 0 0 1 1 1 0 Predicted AdoMet-dependent methyltransferase Methyltransf_18 PF12847.7 ELR18561.1 - 0.14 12.1 0.0 0.21 11.5 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain TauD PF02668.16 ELR18563.1 - 6.1e-47 160.7 0.0 1.3e-45 156.3 0.0 2.2 1 1 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family DUF971 PF06155.12 ELR18563.1 - 1.1e-14 54.8 1.2 3.1e-12 47.0 0.1 2.4 1 1 1 2 2 2 2 Protein of unknown function (DUF971) DUF4706 PF15797.5 ELR18563.1 - 0.04 14.4 0.1 1.5 9.3 0.1 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF4706) Tudor_2 PF18104.1 ELR18563.1 - 3.7 7.3 4.7 22 4.8 0.6 2.5 2 0 0 2 2 2 0 Jumonji domain-containing protein 2A Tudor domain DUF3459 PF11941.8 ELR18563.1 - 6 7.3 7.5 0.95 9.8 1.5 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF3459) zf-Tim10_DDP PF02953.15 ELR18564.1 - 2.4e-09 36.7 0.9 3.9e-09 36.0 0.9 1.3 1 0 0 1 1 1 1 Tim10/DDP family zinc finger EF-hand_6 PF13405.6 ELR18564.1 - 0.003 17.3 0.0 0.015 15.2 0.0 2.1 2 0 0 2 2 2 1 EF-hand domain EF-hand_7 PF13499.6 ELR18564.1 - 0.0067 16.8 0.7 0.011 16.2 0.2 1.7 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_1 PF00036.32 ELR18564.1 - 0.016 14.7 0.4 0.45 10.2 0.0 2.7 3 0 0 3 3 3 0 EF hand EF-hand_8 PF13833.6 ELR18564.1 - 0.028 14.2 0.3 2.2 8.2 0.1 2.7 2 1 0 2 2 2 0 EF-hand domain pair WYL_2 PF10902.8 ELR18564.1 - 0.036 14.4 0.1 0.054 13.9 0.1 1.3 1 0 0 1 1 1 0 WYL_2, Sm-like SH3 beta-barrel fold RTX_C PF08339.10 ELR18564.1 - 0.13 12.3 0.0 0.15 12.1 0.0 1.3 1 1 0 1 1 1 0 RTX C-terminal domain Cyclin_N PF00134.23 ELR18565.1 - 8.8e-26 90.1 0.0 7.3e-24 83.9 0.0 2.2 2 0 0 2 2 2 2 Cyclin, N-terminal domain Cyclin_C PF02984.19 ELR18565.1 - 3.5e-10 40.0 0.1 1.3e-09 38.2 0.0 2.0 1 1 2 3 3 3 1 Cyclin, C-terminal domain MORN PF02493.20 ELR18567.1 - 2.4e-63 206.4 87.3 3e-06 26.8 3.0 14.2 14 0 0 14 14 14 13 MORN repeat RhoGEF PF00621.20 ELR18567.1 - 1.7e-42 145.7 1.8 1.7e-42 145.7 1.8 1.6 2 0 0 2 2 2 1 RhoGEF domain PX PF00787.24 ELR18567.1 - 2.5e-19 69.3 0.0 4.9e-19 68.4 0.0 1.5 1 0 0 1 1 1 1 PX domain SH3_1 PF00018.28 ELR18567.1 - 4e-07 29.5 0.6 4e-07 29.5 0.6 2.5 2 0 0 2 2 2 1 SH3 domain SH3_9 PF14604.6 ELR18567.1 - 3.1e-06 27.0 0.9 3.1e-06 27.0 0.9 2.4 2 0 0 2 2 2 1 Variant SH3 domain SH3_2 PF07653.17 ELR18567.1 - 9.6e-06 25.2 0.0 3.4e-05 23.4 0.0 2.0 1 0 0 1 1 1 1 Variant SH3 domain Maf PF02545.14 ELR18568.1 - 2e-32 112.3 0.0 2.3e-32 112.2 0.0 1.0 1 0 0 1 1 1 1 Maf-like protein DUF5549 PF17703.1 ELR18569.1 - 0.48 10.1 7.5 0.67 9.6 7.5 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5549) DUF4649 PF15507.6 ELR18570.1 - 0.2 11.6 0.0 0.38 10.7 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4649) Gemin6 PF06372.12 ELR18571.1 - 2.5e-16 59.7 0.0 2.8e-15 56.3 0.0 2.1 1 1 0 1 1 1 1 Gemin6 protein AD PF09793.9 ELR18571.1 - 0.025 14.7 0.0 0.043 14.0 0.0 1.5 1 1 0 1 1 1 0 Anticodon-binding domain RESP18 PF14948.6 ELR18571.1 - 0.16 12.3 0.6 12 6.3 0.0 2.4 1 1 1 2 2 2 0 RESP18 domain SapB_1 PF05184.15 ELR18572.1 - 4.5e-13 48.9 0.5 4.5e-13 48.9 0.5 2.4 3 0 0 3 3 3 1 Saposin-like type B, region 1 SapB_2 PF03489.17 ELR18572.1 - 8.9e-05 22.5 0.3 0.00022 21.3 0.3 1.7 1 0 0 1 1 1 1 Saposin-like type B, region 2 Epimerase PF01370.21 ELR18573.1 - 1.2e-18 67.4 0.1 2.1e-18 66.7 0.1 1.4 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 ELR18573.1 - 5.6e-10 39.4 0.0 6.8e-10 39.1 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding GDP_Man_Dehyd PF16363.5 ELR18573.1 - 2.6e-09 37.0 0.3 0.067 12.6 0.0 3.9 3 1 0 3 3 3 3 GDP-mannose 4,6 dehydratase 3Beta_HSD PF01073.19 ELR18573.1 - 5.8e-08 32.1 0.0 2.1e-07 30.2 0.0 1.9 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family RmlD_sub_bind PF04321.17 ELR18573.1 - 9e-07 28.3 0.0 1.3e-06 27.8 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain NmrA PF05368.13 ELR18573.1 - 1.8e-05 24.4 0.0 9.5e-05 22.1 0.0 1.9 2 0 0 2 2 2 1 NmrA-like family adh_short PF00106.25 ELR18573.1 - 0.00014 21.4 0.0 0.00028 20.4 0.0 1.5 2 0 0 2 2 2 1 short chain dehydrogenase Fibrillarin PF01269.17 ELR18573.1 - 0.0015 17.7 0.0 0.0028 16.8 0.0 1.4 1 0 0 1 1 1 1 Fibrillarin NAD_binding_4 PF07993.12 ELR18573.1 - 0.0035 16.6 0.1 0.5 9.5 0.0 3.1 1 1 1 2 2 2 1 Male sterility protein Pyr_redox PF00070.27 ELR18573.1 - 0.065 13.8 0.1 0.13 12.9 0.1 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase CODH_A_N PF18537.1 ELR18574.1 - 0.021 14.8 0.1 0.034 14.2 0.1 1.2 1 0 0 1 1 1 0 Carbon monoxide dehydrogenase subunit alpha N-terminal domain CLP1_P PF16575.5 ELR18575.1 - 8.8e-58 195.2 0.0 2.9e-56 190.3 0.0 2.2 2 0 0 2 2 2 1 mRNA cleavage and polyadenylation factor CLP1 P-loop Clp1 PF06807.14 ELR18575.1 - 6.9e-33 113.5 0.0 1.1e-32 112.8 0.0 1.4 1 0 0 1 1 1 1 Pre-mRNA cleavage complex II protein Clp1 CLP1_N PF16573.5 ELR18575.1 - 1.7e-26 92.3 0.0 3e-26 91.5 0.0 1.4 1 0 0 1 1 1 1 N-terminal beta-sandwich domain of polyadenylation factor MMR_HSR1 PF01926.23 ELR18575.1 - 0.0023 18.0 0.1 0.1 12.7 0.0 2.5 2 0 0 2 2 2 1 50S ribosome-binding GTPase CbiA PF01656.23 ELR18575.1 - 0.023 14.7 0.0 0.042 13.9 0.0 1.5 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain TniB PF05621.11 ELR18575.1 - 0.031 13.7 0.0 0.061 12.7 0.0 1.4 1 0 0 1 1 1 0 Bacterial TniB protein ABC_tran PF00005.27 ELR18575.1 - 0.095 13.2 0.0 0.42 11.1 0.0 1.9 2 0 0 2 2 2 0 ABC transporter ParA PF10609.9 ELR18575.1 - 0.14 11.6 0.0 0.25 10.8 0.0 1.3 1 0 0 1 1 1 0 NUBPL iron-transfer P-loop NTPase AAA_35 PF14516.6 ELR18575.1 - 0.15 10.8 0.0 0.27 10.0 0.0 1.3 1 0 0 1 1 1 0 AAA-like domain Sigma54_activat PF00158.26 ELR18575.1 - 0.2 11.3 0.0 0.87 9.3 0.0 1.9 2 0 0 2 2 2 0 Sigma-54 interaction domain Exo_endo_phos PF03372.23 ELR18576.1 - 2.8e-05 23.8 0.0 5.4e-05 22.8 0.0 1.4 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Metallophos PF00149.28 ELR18577.1 - 2.4e-09 38.0 0.0 1.5e-08 35.4 0.0 2.0 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase XPG_I PF00867.18 ELR18579.1 - 3.8e-29 100.9 1.1 5.4e-29 100.4 0.0 1.9 2 0 0 2 2 2 1 XPG I-region XPG_N PF00752.17 ELR18579.1 - 2e-14 53.9 0.0 3.9e-14 52.9 0.0 1.5 1 0 0 1 1 1 1 XPG N-terminal domain 5_3_exonuc PF01367.20 ELR18579.1 - 2.2e-06 28.2 0.0 6.6e-06 26.6 0.0 1.8 1 0 0 1 1 1 1 5'-3' exonuclease, C-terminal SAM fold HHH_5 PF14520.6 ELR18579.1 - 0.052 14.2 0.0 0.11 13.1 0.0 1.6 1 0 0 1 1 1 0 Helix-hairpin-helix domain DUF2201_N PF13203.6 ELR18579.1 - 0.65 9.5 4.9 1.1 8.8 4.9 1.4 1 0 0 1 1 1 0 Putative metallopeptidase domain DUF508 PF04370.12 ELR18579.1 - 4.3 7.1 5.2 51 3.6 5.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF508) FXMRP1_C_core PF12235.8 ELR18579.1 - 8.9 7.0 19.2 0.64 10.7 13.9 1.8 2 0 0 2 2 2 0 Fragile X-related 1 protein core C terminal PhyH PF05721.13 ELR18580.1 - 3.3e-18 66.7 0.0 6.5e-18 65.8 0.0 1.5 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) S-methyl_trans PF02574.16 ELR18581.1 - 3.3e-20 73.0 0.1 8.5e-19 68.4 0.1 2.2 1 1 0 1 1 1 1 Homocysteine S-methyltransferase Meth_synt_1 PF08267.12 ELR18581.1 - 0.14 11.6 0.0 0.51 9.8 0.0 1.8 2 0 0 2 2 2 0 Cobalamin-independent synthase, N-terminal domain Pkinase_Tyr PF07714.17 ELR18583.1 - 1.2e-43 149.3 0.0 1.5e-43 149.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ELR18583.1 - 6.1e-28 97.9 0.0 1.2e-27 96.9 0.0 1.4 2 0 0 2 2 2 1 Protein kinase domain APH PF01636.23 ELR18583.1 - 9.6e-05 22.4 0.1 0.0054 16.7 0.0 2.1 2 0 0 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.14 ELR18583.1 - 0.0012 18.2 0.0 0.0024 17.3 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 ELR18583.1 - 0.09 12.4 0.0 0.14 11.7 0.0 1.3 1 0 0 1 1 1 0 RIO1 family EPO_TPO PF00758.18 ELR18584.1 - 0.028 14.5 0.0 0.042 13.9 0.0 1.2 1 0 0 1 1 1 0 Erythropoietin/thrombopoietin DTHCT PF08070.11 ELR18584.1 - 0.47 11.2 3.8 1.3 9.8 3.8 1.8 1 0 0 1 1 1 0 DTHCT (NUC029) region WD40 PF00400.32 ELR18585.1 - 7e-44 146.9 19.2 1.5e-08 35.1 0.1 7.3 7 1 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ELR18585.1 - 1.4e-25 89.4 3.9 0.0029 17.9 0.0 6.9 1 1 6 7 7 7 5 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 ELR18585.1 - 1.2e-06 28.5 0.5 0.0019 18.1 0.0 3.2 1 1 3 4 4 4 3 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 ELR18585.1 - 2.3e-06 26.8 8.8 0.87 8.5 0.0 5.6 1 1 4 6 6 6 3 WD40 region of Ge1, enhancer of mRNA-decapping protein IKI3 PF04762.12 ELR18585.1 - 3.2e-06 25.5 1.6 0.076 11.0 0.0 3.3 1 1 0 3 3 3 2 IKI3 family PQQ_2 PF13360.6 ELR18585.1 - 8.2e-06 25.6 2.0 0.00016 21.3 1.7 2.1 1 1 1 2 2 2 1 PQQ-like domain Nup160 PF11715.8 ELR18585.1 - 6.4e-05 21.8 3.7 0.0009 18.0 0.2 2.6 2 1 1 3 3 3 1 Nucleoporin Nup120/160 WD40_like PF17005.5 ELR18585.1 - 0.00011 21.6 0.0 1.3 8.3 0.0 3.9 1 1 3 4 4 4 1 WD40-like domain Cytochrom_D1 PF02239.16 ELR18585.1 - 0.00015 20.5 0.1 0.022 13.3 0.0 3.0 1 1 2 3 3 3 1 Cytochrome D1 heme domain PD40 PF07676.12 ELR18585.1 - 0.00041 20.2 2.1 0.13 12.3 0.2 3.4 4 0 0 4 4 3 1 WD40-like Beta Propeller Repeat PALB2_WD40 PF16756.5 ELR18585.1 - 0.0019 17.2 0.9 0.96 8.3 0.1 3.3 2 1 1 3 3 3 1 Partner and localizer of BRCA2 WD40 domain DUF1513 PF07433.11 ELR18585.1 - 0.0056 15.8 4.1 0.76 8.8 0.2 3.8 2 1 2 4 4 4 1 Protein of unknown function (DUF1513) Nbas_N PF15492.6 ELR18585.1 - 0.01 15.2 0.2 7.7 5.7 0.0 3.1 3 1 1 4 4 4 0 Neuroblastoma-amplified sequence, N terminal Me-amine-dh_H PF06433.11 ELR18585.1 - 0.017 14.0 0.3 2.9 6.7 0.0 3.4 2 2 2 4 4 4 0 Methylamine dehydrogenase heavy chain (MADH) Proteasome_A_N PF10584.9 ELR18585.1 - 0.019 14.6 0.0 1.3 8.8 0.0 3.5 3 0 0 3 3 3 0 Proteasome subunit A N-terminal signature DUF4221 PF13970.6 ELR18585.1 - 0.031 13.8 0.0 11 5.4 0.0 2.6 2 1 1 3 3 3 0 Domain of unknown function (DUF4221) TruB_C PF09142.11 ELR18585.1 - 0.032 14.0 0.5 20 5.0 0.0 4.2 5 0 0 5 5 5 0 tRNA Pseudouridine synthase II, C terminal Gmad1 PF10647.9 ELR18585.1 - 0.04 13.7 3.8 0.074 12.8 0.4 2.9 1 1 2 3 3 3 0 Lipoprotein LpqB beta-propeller domain DUF5046 PF16465.5 ELR18585.1 - 0.053 13.0 0.0 1 8.8 0.0 2.6 1 1 1 3 3 3 0 Domain of unknown function (DUF5046) PQQ_3 PF13570.6 ELR18585.1 - 0.056 13.9 0.1 12 6.5 0.0 3.5 3 1 0 3 3 2 0 PQQ-like domain ArlS_N PF18719.1 ELR18585.1 - 0.16 12.2 0.0 6 7.1 0.0 2.7 2 1 0 2 2 2 0 ArlS sensor domain PTPA PF03095.15 ELR18586.1 - 7 6.0 6.9 1.7 8.0 3.1 1.9 2 1 0 2 2 2 0 Phosphotyrosyl phosphate activator (PTPA) protein PI3Ka PF00613.20 ELR18587.1 - 5.4e-58 195.4 1.0 9.9e-58 194.6 1.0 1.4 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) PI3_PI4_kinase PF00454.27 ELR18587.1 - 1e-54 186.0 0.0 1.5e-53 182.2 0.0 2.3 1 1 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase PI3K_C2 PF00792.24 ELR18587.1 - 1e-23 83.8 0.0 2.6e-23 82.5 0.0 1.6 1 0 0 1 1 1 1 Phosphoinositide 3-kinase C2 PI3K_rbd PF00794.18 ELR18587.1 - 1.1e-13 51.3 0.0 5e-13 49.1 0.0 2.2 2 0 0 2 2 2 1 PI3-kinase family, ras-binding domain C2 PF00168.30 ELR18587.1 - 0.00074 19.8 0.0 0.0017 18.6 0.0 1.7 1 0 0 1 1 1 1 C2 domain DUF4135 PF13575.6 ELR18587.1 - 0.12 11.7 0.0 0.23 10.7 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4135) ABC2_membrane PF01061.24 ELR18588.1 - 2.5e-33 115.3 16.4 3.9e-33 114.7 16.4 1.3 1 0 0 1 1 1 1 ABC-2 type transporter ABC_tran PF00005.27 ELR18588.1 - 1.2e-30 106.8 0.0 2.2e-30 106.0 0.0 1.4 1 0 0 1 1 1 1 ABC transporter T2SSE PF00437.20 ELR18588.1 - 0.00014 21.0 1.7 0.0016 17.6 0.1 2.3 2 0 0 2 2 2 1 Type II/IV secretion system protein AAA_16 PF13191.6 ELR18588.1 - 0.00026 21.4 0.0 0.0004 20.8 0.0 1.3 1 0 0 1 1 1 1 AAA ATPase domain AAA_21 PF13304.6 ELR18588.1 - 0.0005 20.0 0.0 0.18 11.6 0.0 2.4 2 0 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system RsgA_GTPase PF03193.16 ELR18588.1 - 0.00062 19.7 0.1 0.0012 18.7 0.1 1.4 1 0 0 1 1 1 1 RsgA GTPase AAA_30 PF13604.6 ELR18588.1 - 0.0009 19.0 0.0 0.0017 18.1 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_25 PF13481.6 ELR18588.1 - 0.0011 18.6 0.0 0.0018 17.8 0.0 1.3 1 0 0 1 1 1 1 AAA domain ABC_ATPase PF09818.9 ELR18588.1 - 0.0017 17.2 0.1 0.0048 15.7 0.1 1.6 2 0 0 2 2 2 1 Predicted ATPase of the ABC class AAA_18 PF13238.6 ELR18588.1 - 0.003 18.1 0.1 0.0078 16.8 0.1 1.8 1 1 0 1 1 1 1 AAA domain AAA_28 PF13521.6 ELR18588.1 - 0.0055 17.0 0.0 0.035 14.4 0.0 2.2 2 0 0 2 2 2 1 AAA domain cobW PF02492.19 ELR18588.1 - 0.0055 16.3 0.0 0.011 15.3 0.0 1.5 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain MMR_HSR1 PF01926.23 ELR18588.1 - 0.0066 16.5 0.0 0.015 15.4 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_22 PF13401.6 ELR18588.1 - 0.0069 16.7 0.0 0.017 15.4 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_23 PF13476.6 ELR18588.1 - 0.0087 16.6 0.1 0.019 15.5 0.1 1.5 1 0 0 1 1 1 1 AAA domain NTPase_1 PF03266.15 ELR18588.1 - 0.01 15.7 0.1 0.15 12.0 0.1 2.2 2 0 0 2 2 2 0 NTPase NACHT PF05729.12 ELR18588.1 - 0.011 15.6 0.0 0.022 14.7 0.0 1.4 1 0 0 1 1 1 0 NACHT domain KAP_NTPase PF07693.14 ELR18588.1 - 0.012 14.8 0.0 0.016 14.5 0.0 1.2 1 0 0 1 1 1 0 KAP family P-loop domain DUF87 PF01935.17 ELR18588.1 - 0.012 15.7 0.3 0.027 14.6 0.3 1.5 1 0 0 1 1 1 0 Helicase HerA, central domain AAA_29 PF13555.6 ELR18588.1 - 0.016 14.9 0.1 0.037 13.8 0.1 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain SRP54 PF00448.22 ELR18588.1 - 0.02 14.5 0.5 0.037 13.6 0.1 1.6 2 0 0 2 2 1 0 SRP54-type protein, GTPase domain SMC_N PF02463.19 ELR18588.1 - 0.022 14.2 0.0 0.066 12.6 0.0 1.7 1 1 0 1 1 1 0 RecF/RecN/SMC N terminal domain ATPase_2 PF01637.18 ELR18588.1 - 0.033 14.1 0.0 0.054 13.4 0.0 1.3 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_35 PF14516.6 ELR18588.1 - 0.059 12.2 0.0 0.089 11.6 0.0 1.2 1 0 0 1 1 1 0 AAA-like domain AAA PF00004.29 ELR18588.1 - 0.059 13.8 0.1 0.2 12.1 0.1 1.9 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_33 PF13671.6 ELR18588.1 - 0.067 13.4 0.0 0.12 12.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_14 PF13173.6 ELR18588.1 - 0.067 13.2 0.0 0.39 10.8 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_5 PF07728.14 ELR18588.1 - 0.083 12.9 0.0 0.19 11.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_19 PF13245.6 ELR18588.1 - 0.095 13.0 0.2 0.21 11.9 0.1 1.6 1 1 0 1 1 1 0 AAA domain dNK PF01712.19 ELR18588.1 - 0.096 12.5 0.0 0.2 11.5 0.0 1.6 1 0 0 1 1 1 0 Deoxynucleoside kinase TsaE PF02367.17 ELR18588.1 - 0.098 12.7 0.1 0.21 11.6 0.1 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE RNA_helicase PF00910.22 ELR18588.1 - 0.099 13.0 0.0 0.21 12.0 0.0 1.5 1 0 0 1 1 1 0 RNA helicase NB-ARC PF00931.22 ELR18588.1 - 0.17 11.0 0.1 0.33 10.1 0.1 1.4 1 0 0 1 1 1 0 NB-ARC domain YpM PF09144.10 ELR18588.1 - 0.17 12.0 0.1 0.51 10.5 0.1 1.8 1 0 0 1 1 1 0 Yersinia pseudo-tuberculosis mitogen SPRY PF00622.28 ELR18589.1 - 1.4e-06 28.4 0.0 2.1e-06 27.8 0.0 1.2 1 0 0 1 1 1 1 SPRY domain AAA PF00004.29 ELR18590.1 - 2.8e-28 99.0 1.0 1.8e-25 89.9 1.0 2.3 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 ELR18590.1 - 2.6e-07 30.4 0.0 1.2e-06 28.2 0.0 2.2 1 1 0 1 1 1 1 AAA+ lid domain Vps4_C PF09336.10 ELR18590.1 - 3.7e-07 30.0 0.0 1e-06 28.6 0.0 1.8 1 0 0 1 1 1 1 Vps4 C terminal oligomerisation domain RuvB_N PF05496.12 ELR18590.1 - 0.00011 22.0 0.1 0.00037 20.3 0.1 1.8 1 1 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 ELR18590.1 - 0.00053 20.3 0.4 0.0047 17.2 0.4 2.3 1 1 0 1 1 1 1 AAA domain AAA_5 PF07728.14 ELR18590.1 - 0.00091 19.2 0.4 0.015 15.3 0.0 2.5 1 1 1 2 2 2 1 AAA domain (dynein-related subfamily) AAA_18 PF13238.6 ELR18590.1 - 0.0042 17.6 0.1 0.013 16.0 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 ELR18590.1 - 0.0073 16.7 0.3 0.027 14.8 0.2 1.9 1 1 0 1 1 1 1 AAA ATPase domain TIP49 PF06068.13 ELR18590.1 - 0.011 15.0 0.0 0.019 14.2 0.0 1.3 1 0 0 1 1 1 0 TIP49 P-loop domain Mg_chelatase PF01078.21 ELR18590.1 - 0.023 14.1 0.2 0.049 13.0 0.2 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_2 PF07724.14 ELR18590.1 - 0.035 14.2 0.2 7.5 6.6 0.1 2.4 1 1 1 2 2 2 0 AAA domain (Cdc48 subfamily) IstB_IS21 PF01695.17 ELR18590.1 - 0.039 13.7 0.0 0.068 12.9 0.0 1.3 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_25 PF13481.6 ELR18590.1 - 0.041 13.5 0.1 2.7 7.5 0.0 2.4 2 0 0 2 2 2 0 AAA domain TniB PF05621.11 ELR18590.1 - 0.067 12.6 0.1 5.4 6.4 0.0 2.3 2 0 0 2 2 2 0 Bacterial TniB protein AAA_7 PF12775.7 ELR18590.1 - 0.22 11.0 0.0 0.44 10.0 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region SR-25 PF10500.9 ELR18590.1 - 3.8 7.0 18.7 0.031 13.9 2.3 2.2 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein UQ_con PF00179.26 ELR18591.1 - 4.9e-27 94.3 0.3 6.1e-27 94.0 0.3 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 ELR18591.1 - 0.0081 16.4 0.4 0.011 16.0 0.4 1.3 1 1 0 1 1 1 1 RWD domain Glyco_hydro_38N PF01074.22 ELR18592.1 - 1.9e-62 211.3 0.3 3.7e-62 210.3 0.3 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 N-terminal domain Glyco_hydro_38C PF07748.13 ELR18592.1 - 7.5e-55 186.3 0.0 1.1e-54 185.7 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 C-terminal domain Alpha-mann_mid PF09261.11 ELR18592.1 - 2.1e-21 75.8 0.3 4.9e-21 74.7 0.3 1.6 1 0 0 1 1 1 1 Alpha mannosidase middle domain Glyco_hydro38C2 PF17677.1 ELR18592.1 - 2e-08 34.2 0.0 4.2e-08 33.2 0.0 1.6 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 C-terminal beta sandwich domain COBRA1 PF06209.13 ELR18593.1 - 5.3e-83 279.5 6.6 3.2e-62 211.0 2.9 2.2 2 0 0 2 2 2 2 Cofactor of BRCA1 (COBRA1) Inj_translocase PF16928.5 ELR18593.1 - 0.21 11.0 1.1 0.53 9.7 0.6 1.8 2 0 0 2 2 2 0 DNA/protein translocase of phage P22 injectosome AAA_35 PF14516.6 ELR18594.1 - 7.4e-06 25.0 0.0 1.2e-05 24.3 0.0 1.3 1 0 0 1 1 1 1 AAA-like domain AAA_16 PF13191.6 ELR18594.1 - 0.1 13.0 0.4 3.3 8.1 0.4 2.5 2 1 0 2 2 2 0 AAA ATPase domain Acetyltransf_1 PF00583.25 ELR18595.1 - 3.8e-09 36.8 0.0 4.7e-09 36.5 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 ELR18595.1 - 2.4e-05 24.3 0.0 3.2e-05 23.8 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 ELR18595.1 - 2.4e-05 24.6 0.0 3.5e-05 24.1 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 ELR18595.1 - 0.00015 21.8 0.0 0.00019 21.5 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Methyltrn_RNA_4 PF09936.9 ELR18595.1 - 0.07 13.0 0.1 10 5.9 0.0 2.3 2 0 0 2 2 2 0 SAM-dependent RNA methyltransferase Peptidase_C1 PF00112.23 ELR18596.1 - 2.3e-65 220.8 2.7 2.9e-65 220.4 2.7 1.1 1 0 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.12 ELR18596.1 - 1.7e-18 66.8 2.7 2.7e-18 66.2 2.7 1.3 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Peptidase_C1_2 PF03051.15 ELR18596.1 - 0.00032 19.6 1.6 0.00071 18.5 0.6 1.8 2 0 0 2 2 2 1 Peptidase C1-like family DUF3574 PF12098.8 ELR18597.1 - 7.2e-25 86.8 0.0 9.9e-25 86.3 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3574) Peptidase_S8 PF00082.22 ELR18598.1 - 5.3e-39 134.2 13.6 1.1e-38 133.2 13.6 1.4 1 1 0 1 1 1 1 Subtilase family Inhibitor_I9 PF05922.16 ELR18598.1 - 0.0033 18.1 0.0 0.006 17.2 0.0 1.4 1 0 0 1 1 1 1 Peptidase inhibitor I9 Aminotran_1_2 PF00155.21 ELR18599.1 - 6.9e-90 301.8 0.0 8e-90 301.6 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II LRR_8 PF13855.6 ELR18600.1 - 1.6e-17 63.0 0.3 7.1e-09 35.3 0.1 2.2 2 0 0 2 2 2 2 Leucine rich repeat LRR_4 PF12799.7 ELR18600.1 - 2e-10 40.7 0.6 1.1e-05 25.7 0.1 2.9 2 1 0 3 3 3 2 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 ELR18600.1 - 8.3e-09 34.8 9.4 0.27 11.9 0.0 6.7 7 0 0 7 7 7 3 Leucine Rich Repeat LRR_6 PF13516.6 ELR18600.1 - 1e-05 25.2 3.4 0.21 11.7 0.0 4.8 5 0 0 5 5 5 3 Leucine Rich repeat Chitin_synth_2 PF03142.15 ELR18601.1 - 1.3e-14 53.8 10.8 2.8e-07 29.5 1.9 3.4 2 1 1 3 3 3 3 Chitin synthase Glyco_tranf_2_3 PF13641.6 ELR18601.1 - 1e-05 25.6 0.5 0.0011 18.9 0.2 2.3 2 0 0 2 2 2 2 Glycosyltransferase like family 2 Glycos_transf_2 PF00535.26 ELR18601.1 - 0.0013 18.6 0.0 0.28 11.0 0.0 2.4 2 0 0 2 2 2 2 Glycosyl transferase family 2 Chitin_synth_1 PF01644.17 ELR18601.1 - 0.17 11.8 0.0 21 5.1 0.0 2.4 2 0 0 2 2 2 0 Chitin synthase RRM_1 PF00076.22 ELR18602.1 - 3.5e-16 58.8 0.0 5.1e-16 58.3 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 ELR18602.1 - 0.025 14.7 0.1 0.025 14.7 0.1 2.5 2 2 0 2 2 2 0 RNA recognition motif Paired_CXXCH_1 PF09699.10 ELR18602.1 - 0.025 14.3 0.2 0.06 13.1 0.2 1.6 1 0 0 1 1 1 0 Doubled CXXCH motif (Paired_CXXCH_1) TFIIA PF03153.13 ELR18602.1 - 0.046 13.7 29.5 0.067 13.2 29.5 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Methyltransf_25 PF13649.6 ELR18603.1 - 3e-07 31.0 0.0 1.7e-06 28.6 0.0 2.2 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 ELR18603.1 - 0.00013 22.6 0.0 0.00084 20.0 0.0 2.3 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 ELR18603.1 - 0.00018 22.1 0.1 0.00065 20.3 0.1 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 ELR18603.1 - 0.0013 18.6 0.0 0.0093 15.8 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain RRM_1 PF00076.22 ELR18604.1 - 8.7e-54 179.2 0.0 3.7e-22 77.9 0.0 3.4 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 ELR18604.1 - 4e-07 30.1 0.0 0.0064 16.6 0.0 2.8 2 0 0 2 2 2 2 RNA recognition motif RRM_occluded PF16842.5 ELR18604.1 - 1.1e-05 25.1 0.0 0.91 9.4 0.0 3.5 3 0 0 3 3 3 2 Occluded RNA-recognition motif RRM_5 PF13893.6 ELR18604.1 - 0.00032 20.3 0.0 2.3 7.8 0.0 3.2 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 ELR18604.1 - 0.0024 17.9 0.0 4.9 7.3 0.0 3.5 3 0 0 3 3 3 2 RNA binding motif DbpA PF03880.15 ELR18604.1 - 0.06 13.3 0.0 38 4.4 0.0 3.4 3 0 0 3 3 3 0 DbpA RNA binding domain RRM_8 PF11835.8 ELR18604.1 - 0.17 12.1 0.0 0.94 9.7 0.0 2.1 2 0 0 2 2 2 0 RRM-like domain DUF1479 PF07350.12 ELR18605.1 - 0.00033 19.6 6.2 0.0076 15.1 0.0 2.6 3 0 0 3 3 3 2 Protein of unknown function (DUF1479) Myc_N PF01056.18 ELR18605.1 - 0.22 11.4 9.4 0.36 10.7 9.4 1.4 1 0 0 1 1 1 0 Myc amino-terminal region PhyH PF05721.13 ELR18605.1 - 0.38 11.0 7.9 0.079 13.2 1.1 2.9 2 1 0 2 2 2 0 Phytanoyl-CoA dioxygenase (PhyH) SURF2 PF05477.11 ELR18605.1 - 0.49 10.1 12.2 0.82 9.3 12.2 1.3 1 0 0 1 1 1 0 Surfeit locus protein 2 (SURF2) GAGA_bind PF06217.12 ELR18605.1 - 0.55 10.5 5.8 0.71 10.1 5.8 1.2 1 0 0 1 1 1 0 GAGA binding protein-like family RR_TM4-6 PF06459.12 ELR18605.1 - 0.73 9.6 18.9 1.1 9.0 18.9 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Nop53 PF07767.11 ELR18605.1 - 2.1 7.6 27.2 3.1 7.1 27.2 1.1 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) SDA1 PF05285.12 ELR18605.1 - 2.7 7.3 28.1 4 6.8 28.1 1.1 1 0 0 1 1 1 0 SDA1 Nop14 PF04147.12 ELR18605.1 - 3.5 5.7 26.5 4.4 5.4 26.5 1.1 1 0 0 1 1 1 0 Nop14-like family Ank_2 PF12796.7 ELR18606.1 - 7.4e-47 157.9 9.5 1.1e-15 57.9 0.0 4.3 2 2 3 5 5 5 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ELR18606.1 - 4.5e-37 126.0 8.2 1.7e-09 38.0 0.0 6.2 4 2 3 7 7 7 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 ELR18606.1 - 3.2e-32 106.9 11.4 9.5e-05 22.5 0.0 8.6 9 0 0 9 9 9 7 Ankyrin repeat Ank PF00023.30 ELR18606.1 - 5.2e-32 108.9 19.3 0.00089 19.6 0.1 8.4 8 0 0 8 8 8 8 Ankyrin repeat Ank_5 PF13857.6 ELR18606.1 - 3.1e-29 100.6 14.9 9.8e-08 32.1 0.1 7.9 3 2 6 9 9 9 7 Ankyrin repeats (many copies) VPS9 PF02204.18 ELR18607.1 - 9.4e-18 64.4 0.2 1.9e-17 63.4 0.2 1.5 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain MEIOC PF15189.6 ELR18607.1 - 0.07 12.7 0.0 0.13 11.9 0.0 1.3 1 0 0 1 1 1 0 Meiosis-specific coiled-coil domain-containing protein MEIOC Lactamase_B PF00753.27 ELR18608.1 - 7.7e-16 58.7 4.0 4.9e-14 52.8 4.0 2.4 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Rhodanese PF00581.20 ELR18608.1 - 2.8e-14 53.5 0.0 4.7e-14 52.8 0.0 1.4 1 0 0 1 1 1 1 Rhodanese-like domain SelR PF01641.18 ELR18609.1 - 0.031 14.4 0.5 0.2 11.7 0.0 2.2 2 0 0 2 2 2 0 SelR domain HECT_2 PF09814.9 ELR18609.1 - 0.043 12.7 1.7 0.69 8.7 0.0 2.1 1 1 1 2 2 2 0 HECT-like Ubiquitin-conjugating enzyme (E2)-binding Trm112p PF03966.16 ELR18609.1 - 0.061 13.9 0.0 0.17 12.5 0.0 1.7 1 0 0 1 1 1 0 Trm112p-like protein F-box-like PF12937.7 ELR18610.1 - 1.1e-05 25.2 0.0 2.2e-05 24.3 0.0 1.5 1 0 0 1 1 1 1 F-box-like SPRY PF00622.28 ELR18610.1 - 0.0017 18.5 0.0 0.0028 17.8 0.0 1.3 1 0 0 1 1 1 1 SPRY domain F-box PF00646.33 ELR18610.1 - 0.011 15.6 0.0 0.022 14.7 0.0 1.5 1 0 0 1 1 1 0 F-box domain F-box_4 PF15966.5 ELR18610.1 - 0.056 13.3 0.0 0.14 12.1 0.0 1.7 2 0 0 2 2 2 0 F-box GATA PF00320.27 ELR18611.1 - 0.00015 21.3 4.4 0.00028 20.4 4.4 1.4 1 0 0 1 1 1 1 GATA zinc finger F420_oxidored PF03807.17 ELR18612.1 - 2e-07 31.5 1.6 6.4e-07 29.9 1.6 1.9 1 1 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent 2-Hacid_dh_C PF02826.19 ELR18612.1 - 0.0011 18.3 1.1 0.0039 16.6 0.3 2.2 2 1 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Semialdhyde_dh PF01118.24 ELR18612.1 - 0.009 16.5 0.0 0.017 15.6 0.0 1.5 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain NAD_Gly3P_dh_N PF01210.23 ELR18612.1 - 0.051 13.5 0.3 0.14 12.2 0.3 1.7 1 1 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus IlvN PF07991.12 ELR18612.1 - 0.079 12.5 0.4 0.18 11.4 0.4 1.5 1 1 0 1 1 1 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain ApbA PF02558.16 ELR18612.1 - 0.12 12.0 0.2 0.23 11.1 0.2 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA Ferric_reduct PF01794.19 ELR18612.1 - 0.29 11.3 9.6 0.067 13.3 4.6 2.3 1 1 1 2 2 2 0 Ferric reductase like transmembrane component NOA36 PF06524.12 ELR18612.1 - 2.5 7.3 4.8 3.7 6.8 4.8 1.2 1 0 0 1 1 1 0 NOA36 protein SMC_N PF02463.19 ELR18613.1 - 8.6e-60 201.9 11.5 5.4e-59 199.3 11.5 2.4 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 ELR18613.1 - 1.2e-28 99.8 0.2 3.8e-28 98.1 0.2 2.0 1 0 0 1 1 1 1 SMC proteins Flexible Hinge Domain AAA_21 PF13304.6 ELR18613.1 - 1.1e-10 41.9 0.1 1e-05 25.5 0.0 5.0 3 2 0 5 5 5 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 ELR18613.1 - 1.2e-09 39.0 21.1 1.2e-09 39.0 21.1 7.2 2 2 1 4 4 1 1 AAA domain AAA_15 PF13175.6 ELR18613.1 - 7.3e-08 32.5 21.3 7.3e-08 32.5 21.3 4.3 2 2 2 4 4 2 1 AAA ATPase domain AAA_29 PF13555.6 ELR18613.1 - 1.1e-07 31.5 0.0 2.7e-07 30.2 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain APG6_N PF17675.1 ELR18613.1 - 0.002 18.7 23.4 0.002 18.7 23.4 8.7 3 3 6 9 9 7 2 Apg6 coiled-coil region SbcCD_C PF13558.6 ELR18613.1 - 0.002 18.3 0.0 0.011 16.0 0.0 2.3 1 0 0 1 1 1 1 Putative exonuclease SbcCD, C subunit ADIP PF11559.8 ELR18613.1 - 0.0025 17.9 19.9 0.0025 17.9 19.9 8.1 4 3 3 9 9 9 2 Afadin- and alpha -actinin-Binding AAA_22 PF13401.6 ELR18613.1 - 0.012 15.9 1.6 7.7 6.8 0.0 4.2 3 1 0 3 3 3 0 AAA domain Baculo_PEP_C PF04513.12 ELR18613.1 - 0.041 13.9 25.9 2.2 8.3 0.2 6.2 5 2 0 5 5 5 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF3882 PF07066.11 ELR18613.1 - 0.12 12.4 0.7 2.4 8.2 0.2 2.5 2 0 0 2 2 2 0 Lactococcus phage M3 protein ABC_tran PF00005.27 ELR18613.1 - 0.44 11.1 0.0 0.44 11.1 0.0 6.7 4 3 0 4 4 2 0 ABC transporter TAF6_C PF07571.13 ELR18614.1 - 2.8e-31 107.7 0.1 6.7e-31 106.5 0.1 1.7 1 0 0 1 1 1 1 TAF6 C-terminal HEAT repeat domain TAF PF02969.17 ELR18614.1 - 0.00026 21.1 0.1 0.0012 19.0 0.3 2.0 2 0 0 2 2 2 1 TATA box binding protein associated factor (TAF) MMS19_C PF12460.8 ELR18614.1 - 0.024 13.8 0.0 0.035 13.2 0.0 1.3 1 0 0 1 1 1 0 RNAPII transcription regulator C-terminal Ras PF00071.22 ELR18616.1 - 1.9e-24 86.1 0.0 3.1e-24 85.4 0.0 1.3 1 0 0 1 1 1 1 Ras family UBA_4 PF14555.6 ELR18616.1 - 3e-16 59.0 0.2 6.7e-16 57.8 0.2 1.7 1 0 0 1 1 1 1 UBA-like domain Roc PF08477.13 ELR18616.1 - 1.5e-05 25.2 0.0 2.8e-05 24.3 0.0 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR18616.1 - 0.00055 19.4 0.0 0.0012 18.3 0.0 1.5 1 0 0 1 1 1 1 ADP-ribosylation factor family AAA_23 PF13476.6 ELR18616.1 - 0.15 12.5 0.4 0.33 11.4 0.4 1.5 1 0 0 1 1 1 0 AAA domain DUF3168 PF11367.8 ELR18616.1 - 3.2 8.0 6.8 0.64 10.2 0.3 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF3168) Allene_ox_cyc PF06351.11 ELR18617.1 - 3.9e-05 23.5 0.1 4.4e-05 23.3 0.1 1.1 1 0 0 1 1 1 1 Allene oxide cyclase Dirigent PF03018.14 ELR18617.1 - 8.6e-05 22.4 0.0 0.0001 22.1 0.0 1.1 1 0 0 1 1 1 1 Dirigent-like protein Hydrolase_4 PF12146.8 ELR18618.1 - 1.2e-05 24.7 0.4 0.23 10.7 0.0 3.0 2 1 0 3 3 3 2 Serine aminopeptidase, S33 DLH PF01738.18 ELR18618.1 - 2.9e-05 23.7 0.0 3.3e-05 23.6 0.0 1.1 1 0 0 1 1 1 1 Dienelactone hydrolase family Abhydrolase_6 PF12697.7 ELR18618.1 - 0.0017 19.0 0.5 0.2 12.2 0.1 2.0 1 1 1 2 2 2 2 Alpha/beta hydrolase family Peptidase_S9 PF00326.21 ELR18618.1 - 0.002 17.6 1.6 0.76 9.2 0.0 2.6 2 1 0 3 3 3 2 Prolyl oligopeptidase family DUF4574 PF15141.6 ELR18618.1 - 0.0067 16.3 0.0 0.012 15.5 0.0 1.4 1 0 0 1 1 1 1 Ubiquinol-cytochrome-c reductase complex assembly factor 3 BAAT_C PF08840.11 ELR18618.1 - 0.023 14.6 0.0 0.069 13.1 0.0 1.6 2 0 0 2 2 2 0 BAAT / Acyl-CoA thioester hydrolase C terminal Peptidase_S15 PF02129.18 ELR18618.1 - 0.031 13.9 0.1 0.12 12.0 0.1 1.7 1 1 1 2 2 2 0 X-Pro dipeptidyl-peptidase (S15 family) Abhydrolase_3 PF07859.13 ELR18618.1 - 0.16 11.8 0.1 0.88 9.4 0.2 1.9 1 1 1 2 2 2 0 alpha/beta hydrolase fold PAH PF02671.21 ELR18619.1 - 4e-15 55.7 0.1 6.6e-15 55.0 0.1 1.4 1 0 0 1 1 1 1 Paired amphipathic helix repeat SseB_C PF14581.6 ELR18619.1 - 0.01 15.9 0.1 0.062 13.4 0.1 2.2 1 1 0 1 1 1 0 SseB protein C-terminal domain DUF3506 PF12014.8 ELR18620.1 - 3.3e-08 33.6 1.3 3.6e-05 23.8 1.3 3.8 1 1 0 1 1 1 1 Domain of unknown function (DUF3506) F-box PF00646.33 ELR18620.1 - 1.8e-07 30.9 0.0 3e-07 30.1 0.0 1.4 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 ELR18620.1 - 1e-06 28.5 0.3 1.9e-06 27.6 0.3 1.5 1 0 0 1 1 1 1 F-box-like SART-1 PF03343.13 ELR18622.1 - 5.7e-10 38.4 0.8 7.4e-10 38.0 0.8 1.1 1 0 0 1 1 1 1 SART-1 family 6PF2K PF01591.18 ELR18623.1 - 1.2e-75 253.7 0.0 1.6e-75 253.2 0.0 1.2 1 0 0 1 1 1 1 6-phosphofructo-2-kinase His_Phos_1 PF00300.22 ELR18623.1 - 1.3e-33 116.4 0.1 1.3e-23 83.7 0.0 3.2 3 0 0 3 3 3 3 Histidine phosphatase superfamily (branch 1) AIP3 PF03915.13 ELR18623.1 - 9e-08 31.6 0.0 1.3e-07 31.1 0.0 1.2 1 0 0 1 1 1 1 Actin interacting protein 3 AAA_33 PF13671.6 ELR18623.1 - 0.00044 20.4 0.0 0.0012 19.0 0.0 1.8 1 0 0 1 1 1 1 AAA domain KTI12 PF08433.10 ELR18623.1 - 0.005 16.3 0.1 0.025 14.0 0.0 2.1 2 1 0 2 2 2 1 Chromatin associated protein KTI12 Tubulin PF00091.25 ELR18624.1 - 1.4e-30 107.0 0.0 1.9e-30 106.5 0.0 1.1 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_3 PF14881.6 ELR18624.1 - 5.6e-06 26.2 0.0 7.5e-06 25.7 0.0 1.3 1 0 0 1 1 1 1 Tubulin domain F-box PF00646.33 ELR18624.1 - 0.0012 18.6 0.1 0.0028 17.5 0.1 1.5 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 ELR18624.1 - 0.0058 16.5 0.7 0.0058 16.5 0.7 2.0 2 0 0 2 2 2 1 F-box-like HATPase_c PF02518.26 ELR18625.1 - 6.6e-29 100.7 0.0 1.8e-28 99.3 0.0 1.7 1 1 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 ELR18625.1 - 4.8e-25 87.9 0.0 7.3e-25 87.3 0.0 1.3 1 0 0 1 1 1 1 Response regulator receiver domain PMAIP1 PF15150.6 ELR18625.1 - 0.023 14.6 0.0 0.078 12.9 0.0 1.9 1 0 0 1 1 1 0 Phorbol-12-myristate-13-acetate-induced HATPase_c_2 PF13581.6 ELR18625.1 - 0.044 13.7 0.0 0.25 11.3 0.0 2.2 1 1 0 1 1 1 0 Histidine kinase-like ATPase domain Sulfate_transp PF00916.20 ELR18626.1 - 2.7e-58 197.6 22.6 3.5e-58 197.2 22.6 1.1 1 0 0 1 1 1 1 Sulfate permease family MFS_MOT1 PF16983.5 ELR18626.1 - 1.1e-05 25.8 7.1 1.1e-05 25.8 7.1 3.2 4 0 0 4 4 4 2 Molybdate transporter of MFS superfamily STAS PF01740.21 ELR18626.1 - 0.00028 20.5 0.0 0.0006 19.4 0.0 1.5 1 0 0 1 1 1 1 STAS domain Cwf_Cwc_15 PF04889.12 ELR18626.1 - 0.43 10.3 25.4 0.11 12.2 15.5 2.3 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein MR_MLE_C PF13378.6 ELR18627.1 - 2.3e-16 60.1 0.0 4.4e-16 59.1 0.0 1.4 1 0 0 1 1 1 1 Enolase C-terminal domain-like MR_MLE_N PF02746.16 ELR18627.1 - 0.033 14.4 0.0 0.078 13.2 0.0 1.6 1 0 0 1 1 1 0 Mandelate racemase / muconate lactonizing enzyme, N-terminal domain MAAL_C PF07476.11 ELR18627.1 - 0.12 11.5 0.0 0.18 10.9 0.0 1.2 1 0 0 1 1 1 0 Methylaspartate ammonia-lyase C-terminus OB_NTP_bind PF07717.16 ELR18629.1 - 1.5e-21 76.5 0.2 5.9e-21 74.6 0.1 2.0 2 0 0 2 2 2 1 Oligonucleotide/oligosaccharide-binding (OB)-fold HA2 PF04408.23 ELR18629.1 - 3.6e-19 69.0 0.0 8.9e-19 67.8 0.0 1.7 1 0 0 1 1 1 1 Helicase associated domain (HA2) Helicase_C PF00271.31 ELR18629.1 - 1e-12 48.3 0.0 3.3e-12 46.7 0.0 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 ELR18629.1 - 1.5e-05 24.9 0.1 3.8e-05 23.5 0.1 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_30 PF13604.6 ELR18629.1 - 0.0019 17.9 0.2 0.0036 17.0 0.2 1.4 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 ELR18629.1 - 0.0065 16.8 0.1 0.012 16.0 0.1 1.4 1 0 0 1 1 1 1 AAA domain T2SSE PF00437.20 ELR18629.1 - 0.0068 15.5 0.0 0.014 14.4 0.0 1.5 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_22 PF13401.6 ELR18629.1 - 0.011 16.0 0.0 0.03 14.6 0.0 1.8 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 ELR18629.1 - 0.026 15.0 0.0 0.052 14.1 0.0 1.5 1 0 0 1 1 1 0 ABC transporter AAA_7 PF12775.7 ELR18629.1 - 0.027 14.0 0.0 0.055 13.0 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region SRP54 PF00448.22 ELR18629.1 - 0.031 13.9 0.2 0.075 12.7 0.2 1.6 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain cobW PF02492.19 ELR18629.1 - 0.073 12.7 1.1 0.93 9.1 0.1 2.4 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain TrwB_AAD_bind PF10412.9 ELR18629.1 - 0.11 11.3 0.0 0.21 10.5 0.0 1.3 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain Vps16_C PF04840.12 ELR18630.1 - 1.8e-85 286.8 1.5 2.5e-85 286.4 1.5 1.1 1 0 0 1 1 1 1 Vps16, C-terminal region Vps16_N PF04841.13 ELR18630.1 - 4e-85 286.1 0.0 5.3e-85 285.6 0.0 1.1 1 0 0 1 1 1 1 Vps16, N-terminal region ANAPC4_WD40 PF12894.7 ELR18630.1 - 0.0034 17.7 0.1 2.4 8.5 0.1 3.7 3 1 0 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain V-ATPase_C PF03223.15 ELR18631.1 - 1.1e-118 396.8 0.0 1.3e-118 396.7 0.0 1.0 1 0 0 1 1 1 1 V-ATPase subunit C Met_synt_B12 PF02965.17 ELR18631.1 - 0.0062 16.0 0.3 0.22 11.0 0.1 2.3 1 1 0 2 2 2 1 Vitamin B12 dependent methionine synthase, activation domain Scm3 PF10384.9 ELR18631.1 - 0.037 13.8 0.0 0.12 12.2 0.0 1.8 2 0 0 2 2 2 0 Centromere protein Scm3 Tcf25 PF04910.14 ELR18632.1 - 2.5e-60 204.4 0.0 3.1e-35 121.9 0.0 2.1 1 1 1 2 2 2 2 Transcriptional repressor TCF25 TPR_19 PF14559.6 ELR18632.1 - 0.00013 22.3 0.0 0.024 15.1 0.0 3.0 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.6 ELR18632.1 - 0.0003 21.3 0.2 1.7 9.7 0.0 3.9 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.17 ELR18632.1 - 0.0057 16.7 1.8 2.5 8.4 0.0 3.7 4 0 0 4 4 3 1 Tetratricopeptide repeat TPR_12 PF13424.6 ELR18632.1 - 0.012 15.9 0.4 1.6 9.1 0.0 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_7 PF13176.6 ELR18632.1 - 0.03 14.3 0.1 26 5.2 0.0 3.7 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_8 PF13181.6 ELR18632.1 - 0.077 13.3 0.1 43 4.7 0.0 3.6 4 0 0 4 4 3 0 Tetratricopeptide repeat YL1 PF05764.13 ELR18632.1 - 0.13 12.4 11.5 0.22 11.6 11.5 1.4 1 0 0 1 1 1 0 YL1 nuclear protein TPR_4 PF07721.14 ELR18632.1 - 0.35 11.6 5.1 2.9 8.8 0.0 3.4 3 0 0 3 3 2 0 Tetratricopeptide repeat NARP1 PF12569.8 ELR18632.1 - 0.38 9.6 0.0 0.38 9.6 0.0 2.2 2 0 0 2 2 1 0 NMDA receptor-regulated protein 1 Nop53 PF07767.11 ELR18632.1 - 1.6 8.0 13.9 2.6 7.3 13.9 1.3 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) CDC45 PF02724.14 ELR18632.1 - 6.8 4.9 9.2 9.2 4.4 9.2 1.1 1 0 0 1 1 1 0 CDC45-like protein Bromodomain PF00439.25 ELR18633.1 - 2.4e-07 30.7 0.0 4.8e-07 29.7 0.0 1.5 1 0 0 1 1 1 1 Bromodomain BET PF17035.5 ELR18633.1 - 4.3e-07 30.0 0.0 4.3e-07 30.0 0.0 2.6 3 0 0 3 3 3 1 Bromodomain extra-terminal - transcription regulation Alg6_Alg8 PF03155.15 ELR18634.1 - 1.8e-159 531.8 6.6 2.3e-159 531.4 6.6 1.1 1 0 0 1 1 1 1 ALG6, ALG8 glycosyltransferase family PT PF04886.12 ELR18634.1 - 0.34 10.5 5.4 0.6 9.7 5.4 1.3 1 0 0 1 1 1 0 PT repeat LIM PF00412.22 ELR18635.1 - 1.3e-49 166.2 31.2 3.5e-15 56.0 0.1 4.1 3 1 1 4 4 4 4 LIM domain DNA_pol_A_exo1 PF01612.20 ELR18636.1 - 5.8e-44 149.9 0.8 8.4e-44 149.4 0.8 1.2 1 0 0 1 1 1 1 3'-5' exonuclease PMC2NT PF08066.12 ELR18636.1 - 9.3e-14 51.9 0.0 2.9e-13 50.3 0.0 1.9 1 0 0 1 1 1 1 PMC2NT (NUC016) domain HRDC PF00570.23 ELR18636.1 - 1.1e-12 47.7 0.0 2.7e-12 46.5 0.0 1.7 1 0 0 1 1 1 1 HRDC domain USP19_linker PF16602.5 ELR18636.1 - 8.1 7.0 15.4 0.078 13.5 1.4 3.1 3 0 0 3 3 3 0 Linker region of USP19 deubiquitinase Pkinase PF00069.25 ELR18637.1 - 1.1e-62 211.8 0.1 4.4e-62 209.8 0.0 2.0 3 0 0 3 3 3 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR18637.1 - 4.4e-40 137.6 0.0 2.2e-38 132.0 0.0 2.5 2 1 0 2 2 2 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 ELR18637.1 - 1.5e-05 23.9 0.0 1.5e-05 23.9 0.0 2.3 2 1 0 2 2 1 1 Fungal protein kinase APG6_N PF17675.1 ELR18637.1 - 0.00035 21.1 5.9 0.00035 21.1 5.9 4.1 4 1 0 4 4 4 1 Apg6 coiled-coil region Kinase-like PF14531.6 ELR18637.1 - 0.00072 19.0 0.3 0.0026 17.1 0.0 2.1 2 0 0 2 2 2 1 Kinase-like APH PF01636.23 ELR18637.1 - 0.0025 17.8 0.1 0.0025 17.8 0.1 2.9 2 1 1 3 3 3 1 Phosphotransferase enzyme family Kdo PF06293.14 ELR18637.1 - 0.0028 17.0 3.1 0.0057 16.0 0.0 2.4 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family ERM PF00769.19 ELR18637.1 - 0.0078 16.1 13.4 0.0078 16.1 13.4 3.5 4 0 0 4 4 4 1 Ezrin/radixin/moesin family Fez1 PF06818.15 ELR18637.1 - 0.013 15.9 15.5 0.013 15.9 15.5 2.9 3 0 0 3 3 3 0 Fez1 TMF_TATA_bd PF12325.8 ELR18637.1 - 0.019 15.2 2.2 0.019 15.2 2.2 4.4 3 1 1 4 4 3 0 TATA element modulatory factor 1 TATA binding DUF3685 PF12452.8 ELR18637.1 - 0.076 12.7 0.8 0.16 11.7 0.8 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3685) FapA PF03961.13 ELR18637.1 - 0.29 9.7 11.0 1 7.9 0.2 2.4 2 0 0 2 2 2 0 Flagellar Assembly Protein A TACC_C PF05010.14 ELR18637.1 - 0.73 9.6 22.8 0.1 12.4 11.8 2.7 2 0 0 2 2 2 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal DUF4201 PF13870.6 ELR18637.1 - 3.2 7.5 34.1 0.27 10.9 13.7 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4201) Ish1 PF10281.9 ELR18638.1 - 0.16 12.3 0.0 0.35 11.2 0.0 1.6 1 0 0 1 1 1 0 Putative stress-responsive nuclear envelope protein Laminin_G_3 PF13385.6 ELR18639.1 - 4.6e-21 75.6 0.8 8e-21 74.8 0.8 1.4 1 1 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Sialidase PF02973.16 ELR18639.1 - 0.042 13.3 0.0 0.14 11.6 0.0 1.8 1 1 0 1 1 1 0 Sialidase, N-terminal domain GH114_assoc PF14741.6 ELR18639.1 - 0.15 12.3 0.0 0.25 11.6 0.0 1.3 1 0 0 1 1 1 0 N-terminal glycosyl-hydrolase-114-associated domain Glyco_tran_28_C PF04101.16 ELR18641.1 - 1.6e-23 83.5 0.0 1.7e-23 83.4 0.0 1.0 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain PucR PF07905.11 ELR18641.1 - 0.0072 16.6 0.1 0.011 16.0 0.1 1.4 1 0 0 1 1 1 1 Purine catabolism regulatory protein-like family COX8 PF02285.15 ELR18641.1 - 0.12 12.3 0.1 0.24 11.3 0.1 1.4 1 0 0 1 1 1 0 Cytochrome oxidase c subunit VIII Sec23_trunk PF04811.15 ELR18642.1 - 1.7e-72 243.9 0.0 2.3e-72 243.5 0.0 1.2 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_BS PF08033.12 ELR18642.1 - 8.9e-26 90.5 0.1 1.9e-25 89.4 0.1 1.6 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain Sec23_helical PF04815.15 ELR18642.1 - 1.4e-23 82.7 0.2 3e-23 81.6 0.2 1.6 1 0 0 1 1 1 1 Sec23/Sec24 helical domain zf-Sec23_Sec24 PF04810.15 ELR18642.1 - 3.5e-15 55.8 6.4 6e-15 55.0 6.4 1.4 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Gelsolin PF00626.22 ELR18642.1 - 1.2e-11 44.3 0.0 7.5e-11 41.8 0.0 2.3 1 1 0 1 1 1 1 Gelsolin repeat Vps36-NZF-N PF16988.5 ELR18642.1 - 0.15 11.5 0.0 0.36 10.2 0.0 1.6 1 0 0 1 1 1 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain CLU PF13236.6 ELR18643.1 - 1.4e-48 165.7 0.0 4e-48 164.2 0.0 1.7 2 0 0 2 2 2 1 Clustered mitochondria eIF3_p135 PF12807.7 ELR18643.1 - 2.7e-06 27.6 1.6 1.5e-05 25.1 1.8 2.0 1 1 1 2 2 2 1 Translation initiation factor eIF3 subunit 135 PAS_3 PF08447.12 ELR18644.1 - 0.0013 18.9 0.0 0.0051 17.1 0.0 1.8 2 0 0 2 2 2 1 PAS fold DNA_pol_A_exo1 PF01612.20 ELR18645.1 - 0.00026 20.7 0.0 0.00034 20.4 0.0 1.3 1 1 0 1 1 1 1 3'-5' exonuclease Mito_fiss_reg PF05308.11 ELR18646.1 - 0.13 12.4 3.6 0.13 12.4 3.6 1.0 1 0 0 1 1 1 0 Mitochondrial fission regulator CAP_N PF01213.19 ELR18646.1 - 0.8 9.1 5.3 0.81 9.1 5.3 1.1 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal CLU PF13236.6 ELR18647.1 - 2.4e-06 27.6 0.0 4.4e-06 26.7 0.0 1.4 1 0 0 1 1 1 1 Clustered mitochondria GBP_C PF02841.14 ELR18647.1 - 0.099 12.0 4.0 0.13 11.7 4.0 1.1 1 0 0 1 1 1 0 Guanylate-binding protein, C-terminal domain Anillin PF08174.11 ELR18647.1 - 0.23 11.9 0.7 1.4 9.4 0.1 2.1 1 1 1 2 2 2 0 Cell division protein anillin NUDIX PF00293.28 ELR18648.1 - 0.0015 18.6 0.1 0.42 10.7 0.0 3.0 3 0 0 3 3 3 2 NUDIX domain Cupin_4 PF08007.12 ELR18649.1 - 7.4e-51 173.5 0.1 9.9e-51 173.1 0.1 1.2 1 0 0 1 1 1 1 Cupin superfamily protein Cupin_8 PF13621.6 ELR18649.1 - 4.1e-07 30.0 0.0 0.00014 21.7 0.0 2.6 1 1 0 1 1 1 1 Cupin-like domain Cupin_2 PF07883.11 ELR18649.1 - 0.014 15.1 0.0 0.12 12.0 0.0 2.3 2 0 0 2 2 2 0 Cupin domain RNA_pol_3_Rpc31 PF11705.8 ELR18649.1 - 0.031 14.5 13.8 0.054 13.8 13.8 1.4 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 Cupin_1 PF00190.22 ELR18649.1 - 0.074 12.7 0.0 0.13 11.9 0.0 1.3 1 0 0 1 1 1 0 Cupin TFIIF_alpha PF05793.12 ELR18649.1 - 1.1 7.8 19.1 2 6.9 19.1 1.4 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Nop14 PF04147.12 ELR18649.1 - 3 5.9 15.1 4.3 5.4 15.1 1.1 1 0 0 1 1 1 0 Nop14-like family Usp PF00582.26 ELR18650.1 - 2.7e-21 76.5 0.1 1.1e-20 74.6 0.1 1.8 1 1 0 1 1 1 1 Universal stress protein family Abhydrolase_1 PF00561.20 ELR18651.1 - 2.7e-09 37.0 0.0 1e-08 35.2 0.0 1.9 2 0 0 2 2 2 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 ELR18651.1 - 1.4e-08 34.3 0.0 5.8e-06 25.7 0.0 3.0 3 0 0 3 3 3 2 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 ELR18651.1 - 1.1e-06 29.4 8.6 4.8e-06 27.3 8.6 2.0 1 1 0 1 1 1 1 Alpha/beta hydrolase family Ser_hydrolase PF06821.13 ELR18651.1 - 0.0064 16.4 0.1 0.012 15.4 0.1 1.4 1 0 0 1 1 1 1 Serine hydrolase SSP160 PF06933.11 ELR18651.1 - 0.013 13.7 6.1 0.34 9.1 0.5 2.2 2 0 0 2 2 2 0 Special lobe-specific silk protein SSP160 SPX PF03105.19 ELR18651.1 - 0.054 13.4 0.0 0.073 13.0 0.0 1.4 1 0 0 1 1 1 0 SPX domain LIDHydrolase PF10230.9 ELR18651.1 - 0.11 12.1 0.0 0.18 11.3 0.0 1.3 1 0 0 1 1 1 0 Lipid-droplet associated hydrolase Arb2 PF09757.9 ELR18652.1 - 1.4e-06 27.7 0.0 2e-06 27.1 0.0 1.2 1 0 0 1 1 1 1 Arb2 domain UBA PF00627.31 ELR18652.1 - 6.1e-06 26.0 0.8 1.5e-05 24.8 0.8 1.6 1 0 0 1 1 1 1 UBA/TS-N domain Syja_N PF02383.18 ELR18652.1 - 0.14 11.4 0.0 0.21 10.9 0.0 1.2 1 0 0 1 1 1 0 SacI homology domain Ank PF00023.30 ELR18653.1 - 1.8e-23 81.9 6.7 0.0014 19.0 0.0 6.6 5 2 0 5 5 5 5 Ankyrin repeat Ank_4 PF13637.6 ELR18653.1 - 5.2e-18 65.2 4.4 0.009 16.6 0.6 6.1 4 2 2 6 6 6 5 Ankyrin repeats (many copies) Ank_5 PF13857.6 ELR18653.1 - 5.1e-17 61.7 6.7 0.0004 20.6 0.2 5.2 5 0 0 5 5 5 4 Ankyrin repeats (many copies) Ank_2 PF12796.7 ELR18653.1 - 3.2e-16 59.7 4.3 4.9e-05 23.8 0.1 4.7 3 2 1 4 4 4 4 Ankyrin repeats (3 copies) Ank_3 PF13606.6 ELR18653.1 - 2e-12 46.1 6.7 0.04 14.5 0.0 6.7 6 0 0 6 6 6 3 Ankyrin repeat DUF362 PF04015.12 ELR18653.1 - 0.0047 17.2 0.0 0.0072 16.6 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF362) eIF-5_eIF-2B PF01873.17 ELR18654.1 - 2.4e-22 79.0 0.0 4.5e-22 78.1 0.0 1.5 1 0 0 1 1 1 1 Domain found in IF2B/IF5 W2 PF02020.18 ELR18654.1 - 4.7e-17 61.9 0.1 4.7e-17 61.9 0.1 2.5 2 1 0 2 2 2 1 eIF4-gamma/eIF5/eIF2-epsilon MCM3AP_GANP PF16769.5 ELR18654.1 - 0.082 11.1 1.3 0.12 10.6 1.3 1.2 1 0 0 1 1 1 0 MCM3AP domain of GANP CDC45 PF02724.14 ELR18654.1 - 1.5 7.0 11.4 0.19 10.0 1.7 2.1 2 0 0 2 2 2 0 CDC45-like protein tRNA-synt_His PF13393.6 ELR18655.1 - 9.4e-45 153.2 0.0 1.2e-44 152.8 0.0 1.1 1 0 0 1 1 1 1 Histidyl-tRNA synthetase HGTP_anticodon PF03129.20 ELR18655.1 - 9.7e-07 28.9 0.2 1.9e-06 27.9 0.2 1.5 1 0 0 1 1 1 1 Anticodon binding domain tRNA-synt_2b PF00587.25 ELR18655.1 - 1e-05 25.6 0.0 1.2e-05 25.4 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) tRNA-synt_2d PF01409.20 ELR18655.1 - 0.002 17.6 0.0 0.0042 16.6 0.0 1.5 1 0 0 1 1 1 1 tRNA synthetases class II core domain (F) Alpha-E PF04168.12 ELR18655.1 - 0.057 13.2 0.0 0.087 12.6 0.0 1.2 1 0 0 1 1 1 0 A predicted alpha-helical domain with a conserved ER motif. DIM PF08194.12 ELR18657.1 - 0.16 12.2 1.0 0.34 11.2 1.0 1.5 1 0 0 1 1 1 0 DIM protein Fn_bind PF02986.14 ELR18657.1 - 1.1 9.0 4.6 1.2 9.0 1.9 2.1 2 0 0 2 2 2 0 Fibronectin binding repeat RhoGEF PF00621.20 ELR18659.1 - 6.2e-50 170.0 1.4 1e-49 169.3 1.4 1.4 1 0 0 1 1 1 1 RhoGEF domain PH PF00169.29 ELR18659.1 - 0.00015 22.2 0.0 0.00046 20.7 0.0 1.8 1 0 0 1 1 1 1 PH domain IQ_SEC7_PH PF16453.5 ELR18659.1 - 0.0098 15.9 0.0 0.028 14.4 0.0 1.8 1 0 0 1 1 1 1 PH domain NACHT PF05729.12 ELR18660.1 - 0.0055 16.6 0.0 0.012 15.5 0.0 1.5 1 0 0 1 1 1 1 NACHT domain SUIM_assoc PF16619.5 ELR18660.1 - 0.91 9.6 10.5 4.2 7.5 10.5 2.2 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 VIT PF08487.10 ELR18661.1 - 2.3e-31 108.3 0.0 6.8e-31 106.8 0.0 1.9 1 0 0 1 1 1 1 Vault protein inter-alpha-trypsin domain VWA_3 PF13768.6 ELR18661.1 - 5e-30 104.5 0.1 1.1e-15 57.9 0.0 3.7 1 1 2 3 3 3 3 von Willebrand factor type A domain VIT_2 PF13757.6 ELR18661.1 - 1.6e-15 56.7 0.0 3.3e-15 55.7 0.0 1.5 1 0 0 1 1 1 1 Vault protein inter-alpha-trypsin domain VWA_2 PF13519.6 ELR18661.1 - 9.3e-07 29.5 0.0 0.0032 18.1 0.0 2.7 1 1 1 2 2 2 2 von Willebrand factor type A domain VWA PF00092.28 ELR18661.1 - 0.00014 22.2 0.1 0.011 16.0 0.1 3.1 1 1 2 3 3 3 1 von Willebrand factor type A domain DUF2201 PF09967.9 ELR18661.1 - 0.0046 17.1 0.7 0.76 9.9 0.0 2.8 3 0 0 3 3 3 1 VWA-like domain (DUF2201) Rsa3 PF14615.6 ELR18661.1 - 0.034 13.7 0.1 2 8.0 0.0 2.5 2 0 0 2 2 2 0 Ribosome-assembly protein 3 gpW PF02831.15 ELR18661.1 - 0.096 12.6 0.0 1.3 9.0 0.0 2.7 3 0 0 3 3 3 0 gpW AAA_12 PF13087.6 ELR18662.1 - 2.8e-46 157.7 0.0 5.1e-46 156.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 ELR18662.1 - 8.5e-21 74.9 11.8 3.5e-14 53.2 0.0 3.8 3 2 1 4 4 4 2 AAA domain Viral_helicase1 PF01443.18 ELR18662.1 - 1.4e-09 38.1 0.0 0.0092 15.7 0.0 3.2 3 0 0 3 3 3 3 Viral (Superfamily 1) RNA helicase AAA_30 PF13604.6 ELR18662.1 - 2.8e-05 23.9 0.0 0.14 11.8 0.1 2.6 2 0 0 2 2 2 2 AAA domain UvrD_C_2 PF13538.6 ELR18662.1 - 0.00034 20.4 0.0 0.0023 17.7 0.1 2.2 2 0 0 2 2 2 1 UvrD-like helicase C-terminal domain AAA_19 PF13245.6 ELR18662.1 - 0.0013 19.1 0.3 0.017 15.5 0.0 2.8 2 1 0 2 2 2 1 AAA domain Adeno_IVa2 PF02456.15 ELR18662.1 - 0.13 11.0 0.0 0.24 10.2 0.0 1.3 1 0 0 1 1 1 0 Adenovirus IVa2 protein Exostosin PF03016.15 ELR18663.1 - 1.7e-32 112.9 0.0 2.2e-32 112.5 0.0 1.1 1 0 0 1 1 1 1 Exostosin family Sporozoite_P67 PF05642.11 ELR18665.1 - 0.013 13.7 1.0 0.015 13.4 1.0 1.0 1 0 0 1 1 1 0 Sporozoite P67 surface antigen SR-25 PF10500.9 ELR18665.1 - 8.9 5.8 11.4 12 5.5 11.2 1.3 1 1 0 1 1 1 0 Nuclear RNA-splicing-associated protein Glyco_hydro_15 PF00723.21 ELR18666.1 - 3.2e-09 36.1 0.1 0.00078 18.3 0.0 2.2 1 1 1 2 2 2 2 Glycosyl hydrolases family 15 Glyco_hydro_36 PF17167.4 ELR18666.1 - 0.034 12.8 0.0 0.059 12.0 0.0 1.3 1 0 0 1 1 1 0 Glycosyl hydrolase 36 superfamily, catalytic domain TAF1_subA PF14929.6 ELR18667.1 - 4.4e-15 56.0 0.0 7.2e-15 55.3 0.0 1.2 1 0 0 1 1 1 1 TAF RNA Polymerase I subunit A TPR_19 PF14559.6 ELR18667.1 - 0.029 14.9 1.5 2.1 8.9 0.2 2.9 2 0 0 2 2 2 0 Tetratricopeptide repeat SR-25 PF10500.9 ELR18667.1 - 0.84 9.2 9.8 0.028 14.0 3.1 1.9 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein TPR_14 PF13428.6 ELR18667.1 - 1.2 10.1 0.1 1.2 10.1 0.1 5.3 4 1 1 5 5 5 0 Tetratricopeptide repeat NUDIX PF00293.28 ELR18668.1 - 5.5e-12 45.9 0.1 7.9e-12 45.4 0.1 1.2 1 0 0 1 1 1 1 NUDIX domain NUDIX PF00293.28 ELR18670.1 - 1.2e-19 70.6 0.6 1.7e-19 70.1 0.6 1.2 1 0 0 1 1 1 1 NUDIX domain SH3_2 PF07653.17 ELR18671.1 - 4e-25 87.3 0.2 3e-11 42.8 0.0 3.4 3 0 0 3 3 3 3 Variant SH3 domain SH3_9 PF14604.6 ELR18671.1 - 1.9e-22 78.9 0.1 9.6e-09 35.0 0.1 3.5 3 0 0 3 3 3 3 Variant SH3 domain SH3_1 PF00018.28 ELR18671.1 - 4.5e-20 71.0 3.7 8e-09 35.0 0.2 3.8 3 1 0 3 3 3 3 SH3 domain Fer4_8 PF13183.6 ELR18673.1 - 5.8e-09 36.3 3.6 2.2e-08 34.4 3.8 1.8 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_17 PF13534.6 ELR18673.1 - 3.4e-08 33.9 3.8 7.6e-08 32.8 3.8 1.6 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_10 PF13237.6 ELR18673.1 - 1.1e-05 25.4 2.7 2e-05 24.6 2.7 1.4 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_7 PF12838.7 ELR18673.1 - 0.00055 20.5 2.9 0.0014 19.2 2.9 1.7 1 1 0 1 1 1 1 4Fe-4S dicluster domain Fer4_16 PF13484.6 ELR18673.1 - 0.46 11.4 7.4 2.3 9.2 7.7 2.0 1 1 0 1 1 1 0 4Fe-4S double cluster binding domain Fer4_3 PF12798.7 ELR18673.1 - 5.2 8.3 14.6 14 6.9 1.8 2.3 2 0 0 2 2 2 0 4Fe-4S binding domain Fer4_9 PF13187.6 ELR18673.1 - 6.2 7.1 11.0 44 4.4 5.2 2.2 1 1 1 2 2 2 0 4Fe-4S dicluster domain ABC_membrane PF00664.23 ELR18674.1 - 7e-57 193.2 14.5 9.2e-57 192.8 14.5 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region Abhydrolase_3 PF07859.13 ELR18674.1 - 1.3e-13 51.3 0.0 2.8e-13 50.2 0.0 1.5 2 0 0 2 2 2 1 alpha/beta hydrolase fold ABC_tran PF00005.27 ELR18674.1 - 1.4e-11 45.1 0.0 2.8e-11 44.1 0.0 1.5 1 0 0 1 1 1 1 ABC transporter RsgA_GTPase PF03193.16 ELR18674.1 - 0.051 13.5 0.0 0.095 12.6 0.0 1.4 1 0 0 1 1 1 0 RsgA GTPase AAA_29 PF13555.6 ELR18674.1 - 0.06 13.1 0.1 0.16 11.8 0.1 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_PrkA PF08298.11 ELR18674.1 - 0.14 11.0 0.0 0.24 10.3 0.0 1.2 1 0 0 1 1 1 0 PrkA AAA domain APS_kinase PF01583.20 ELR18674.1 - 0.16 11.8 0.0 0.44 10.4 0.0 1.7 2 0 0 2 2 2 0 Adenylylsulphate kinase DUF4191 PF13829.6 ELR18674.1 - 1.6 8.0 7.6 0.66 9.3 3.8 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4191) PPR_2 PF13041.6 ELR18675.1 - 1.4e-39 134.0 0.0 2.2e-12 46.9 0.0 6.8 4 2 3 7 7 7 7 PPR repeat family PPR_3 PF13812.6 ELR18675.1 - 3.1e-38 129.6 0.0 9.1e-13 48.1 0.0 5.3 5 0 0 5 5 5 5 Pentatricopeptide repeat domain PPR_1 PF12854.7 ELR18675.1 - 1.5e-19 69.4 16.1 0.0025 17.4 0.0 10.2 10 1 0 10 10 10 4 PPR repeat PPR PF01535.20 ELR18675.1 - 1.6e-18 65.6 16.4 0.018 15.2 0.0 8.7 8 1 0 8 8 8 6 PPR repeat PPR_long PF17177.4 ELR18675.1 - 2.3e-18 66.3 0.0 4.4e-08 32.7 0.0 4.0 3 1 1 4 4 4 4 Pentacotripeptide-repeat region of PRORP TPR_16 PF13432.6 ELR18675.1 - 0.0042 17.7 7.2 0.053 14.2 4.4 3.1 2 0 0 2 2 2 1 Tetratricopeptide repeat Glyco_trans_4_3 PF12000.8 ELR18675.1 - 0.0068 16.1 0.1 3.5 7.3 0.0 3.5 3 0 0 3 3 3 1 Glycosyl transferase family 4 group TPR_14 PF13428.6 ELR18675.1 - 0.48 11.4 16.2 11 7.1 0.4 5.8 5 1 2 7 7 7 0 Tetratricopeptide repeat Tubulin PF00091.25 ELR18676.1 - 6.8e-22 78.6 0.1 3.6e-19 69.7 0.1 2.2 1 1 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain F-box-like PF12937.7 ELR18676.1 - 0.00074 19.4 1.0 0.00074 19.4 1.0 2.7 2 1 1 3 3 3 1 F-box-like TALPID3 PF15324.6 ELR18677.1 - 0.63 7.6 1.5 0.76 7.4 1.5 1.0 1 0 0 1 1 1 0 Hedgehog signalling target FYDLN_acid PF09538.10 ELR18678.1 - 1.8 9.3 11.7 0.75 10.5 6.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (FYDLN_acid) DNA_pol_phi PF04931.13 ELR18678.1 - 3.3 5.7 16.2 4.2 5.4 16.2 1.0 1 0 0 1 1 1 0 DNA polymerase phi SIT PF15330.6 ELR18679.1 - 0.71 10.3 5.5 0.16 12.4 1.1 2.2 2 1 0 2 2 2 0 SHP2-interacting transmembrane adaptor protein, SIT WD40 PF00400.32 ELR18681.1 - 3.6e-15 56.1 2.5 2.2e-05 25.1 0.0 6.1 7 0 0 7 7 7 3 WD domain, G-beta repeat F-box-like PF12937.7 ELR18681.1 - 6.2e-08 32.4 0.0 1.2e-07 31.5 0.0 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ELR18681.1 - 5.7e-07 29.3 0.0 1e-06 28.4 0.0 1.4 1 0 0 1 1 1 1 F-box domain ANAPC4_WD40 PF12894.7 ELR18681.1 - 7.2e-06 26.2 0.1 0.00021 21.5 0.1 3.4 3 1 1 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain TALPID3 PF15324.6 ELR18682.1 - 0.79 7.3 1.5 1 7.0 1.5 1.1 1 0 0 1 1 1 0 Hedgehog signalling target Ank_5 PF13857.6 ELR18683.1 - 1e-07 32.0 2.6 0.021 15.1 0.0 5.9 6 1 1 7 7 7 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 ELR18683.1 - 1.1e-07 32.2 0.2 0.086 13.5 0.0 4.6 3 3 0 3 3 3 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 ELR18683.1 - 2.8e-05 24.6 0.0 0.27 11.8 0.0 3.0 2 1 1 3 3 3 2 Ankyrin repeats (3 copies) DUF2514 PF10721.9 ELR18684.1 - 0.0054 16.8 0.2 0.0054 16.8 0.2 3.5 2 2 2 4 4 4 1 Protein of unknown function (DUF2514) Hemagglutinin PF00509.18 ELR18686.1 - 0.027 12.9 0.0 0.036 12.5 0.0 1.3 1 0 0 1 1 1 0 Haemagglutinin Glyco_hydro_53 PF07745.13 ELR18688.1 - 0.0037 16.3 0.4 0.005 15.9 0.4 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 53 Tetraspanin PF00335.20 ELR18690.1 - 0.00031 20.5 10.1 0.00048 19.9 10.1 1.2 1 0 0 1 1 1 1 Tetraspanin family DUF4342 PF14242.6 ELR18690.1 - 0.9 9.6 4.3 1.7 8.7 0.5 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4342) Beta-APP PF03494.13 ELR18690.1 - 0.91 9.4 7.7 1.6 8.6 7.7 1.4 1 0 0 1 1 1 0 Beta-amyloid peptide (beta-APP) DNA_pol_A_exo1 PF01612.20 ELR18691.1 - 1.6e-12 47.5 0.6 6.8e-10 38.9 0.0 2.4 1 1 1 2 2 2 2 3'-5' exonuclease Filament PF00038.21 ELR18691.1 - 0.0035 17.0 3.3 0.0055 16.3 3.3 1.3 1 0 0 1 1 1 1 Intermediate filament protein Mod_r PF07200.13 ELR18691.1 - 0.034 14.2 3.6 0.061 13.4 3.6 1.4 1 0 0 1 1 1 0 Modifier of rudimentary (Mod(r)) protein Baculo_PEP_C PF04513.12 ELR18691.1 - 0.036 14.1 0.3 0.072 13.1 0.3 1.5 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus YabA PF06156.13 ELR18691.1 - 0.038 14.6 1.6 0.08 13.6 1.6 1.6 1 1 0 1 1 1 0 Initiation control protein YabA CENP-H PF05837.12 ELR18691.1 - 0.041 14.3 6.0 0.069 13.6 6.0 1.4 1 0 0 1 1 1 0 Centromere protein H (CENP-H) Cnn_1N PF07989.11 ELR18691.1 - 0.048 13.8 0.8 0.088 13.0 0.8 1.5 1 0 0 1 1 1 0 Centrosomin N-terminal motif 1 Ax_dynein_light PF10211.9 ELR18691.1 - 0.063 13.2 4.2 0.098 12.6 4.2 1.3 1 0 0 1 1 1 0 Axonemal dynein light chain GAS PF13851.6 ELR18691.1 - 0.12 11.7 6.7 0.19 11.1 6.7 1.2 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding OmpH PF03938.14 ELR18691.1 - 0.17 12.2 10.7 0.28 11.5 10.7 1.3 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) APG6_N PF17675.1 ELR18691.1 - 0.2 12.1 9.1 0.44 11.1 9.1 1.6 1 1 0 1 1 1 0 Apg6 coiled-coil region DUF4472 PF14739.6 ELR18691.1 - 0.24 12.2 5.7 0.53 11.0 5.0 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4472) Uso1_p115_C PF04871.13 ELR18691.1 - 0.77 10.1 6.5 1.5 9.2 6.5 1.5 1 0 0 1 1 1 0 Uso1 / p115 like vesicle tethering protein, C terminal region PRKG1_interact PF15898.5 ELR18691.1 - 3.2 8.7 7.2 9 7.3 7.2 1.8 1 1 0 1 1 1 0 cGMP-dependent protein kinase interacting domain DUF1192 PF06698.11 ELR18691.1 - 3.5 7.8 11.3 20 5.4 0.4 2.7 1 1 1 2 2 2 0 Protein of unknown function (DUF1192) ZapB PF06005.12 ELR18691.1 - 6.9 7.2 9.1 24 5.5 9.1 1.9 1 1 0 1 1 1 0 Cell division protein ZapB RhoGAP PF00620.27 ELR18692.1 - 1.5e-07 31.4 0.1 1.5e-07 31.4 0.1 2.7 3 0 0 3 3 3 1 RhoGAP domain SWIRM-assoc_2 PF16496.5 ELR18692.1 - 0.019 13.9 21.0 0.027 13.3 21.0 1.3 1 0 0 1 1 1 0 SWIRM-associated domain at the N-terminal CDC45 PF02724.14 ELR18692.1 - 0.13 10.5 13.7 0.17 10.2 13.7 1.2 1 0 0 1 1 1 0 CDC45-like protein Apt1 PF10351.9 ELR18692.1 - 0.83 8.4 13.7 1.1 8.1 13.7 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain ArAE_2_N PF10337.9 ELR18692.1 - 1.3 7.9 3.5 2.4 7.1 3.5 1.3 1 0 0 1 1 1 0 Putative ER transporter, 6TM, N-terminal SRP-alpha_N PF04086.13 ELR18692.1 - 3.7 7.4 27.4 5.3 6.9 27.4 1.3 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal Borrelia_P83 PF05262.11 ELR18692.1 - 4.6 5.6 25.6 5.8 5.3 25.6 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein GRIP PF01465.20 ELR18693.1 - 1.7e-13 50.2 0.0 5e-13 48.7 0.0 1.9 1 0 0 1 1 1 1 GRIP domain DUF3800 PF12686.7 ELR18693.1 - 0.0098 16.5 0.1 7.4 7.2 0.1 5.2 1 1 0 1 1 1 1 Protein of unknown function (DUF3800) Par3_HAL_N_term PF12053.8 ELR18693.1 - 0.052 13.8 4.8 1.9 8.7 0.1 3.8 3 0 0 3 3 3 0 N-terminal of Par3 and HAL proteins GIT_CC PF16559.5 ELR18693.1 - 5.9 6.8 16.2 0.11 12.4 0.3 6.0 4 0 0 4 4 4 0 GIT coiled-coil Rho guanine nucleotide exchange factor WD40_alt PF14077.6 ELR18693.1 - 9.5 6.2 14.2 4.7 7.1 0.0 5.5 5 0 0 5 5 5 0 Alternative WD40 repeat motif PfkB PF00294.24 ELR18694.1 - 8e-42 143.6 2.7 9.9e-42 143.3 2.7 1.0 1 0 0 1 1 1 1 pfkB family carbohydrate kinase DUF2877 PF11392.8 ELR18694.1 - 0.062 14.0 0.0 15 6.3 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2877) RasGEF PF00617.19 ELR18695.1 - 1.3e-53 181.8 2.1 2.5e-53 180.9 2.1 1.4 1 0 0 1 1 1 1 RasGEF domain XylR_N PF06505.11 ELR18695.1 - 1.1e-06 28.2 0.0 7.2e-05 22.5 0.0 2.5 2 0 0 2 2 2 1 Activator of aromatic catabolism V4R PF02830.18 ELR18695.1 - 2.9e-06 27.2 0.4 0.0016 18.4 0.0 2.5 2 0 0 2 2 2 2 V4R domain Y_phosphatase2 PF03162.13 ELR18696.1 - 4.2e-52 176.1 0.0 4.6e-52 175.9 0.0 1.0 1 0 0 1 1 1 1 Tyrosine phosphatase family DSPc PF00782.20 ELR18696.1 - 0.11 12.3 0.0 0.15 11.9 0.0 1.3 1 1 0 1 1 1 0 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 ELR18696.1 - 0.18 11.8 0.0 0.31 11.0 0.0 1.6 1 1 0 1 1 1 0 Tyrosine phosphatase family PH PF00169.29 ELR18698.1 - 3.9e-62 207.3 9.1 1.9e-22 79.7 0.4 3.8 4 0 0 4 4 4 3 PH domain PH_11 PF15413.6 ELR18698.1 - 3e-20 72.6 19.5 2.4e-08 34.4 0.7 5.9 4 2 0 4 4 4 3 Pleckstrin homology domain PH_3 PF14593.6 ELR18698.1 - 3.4e-16 59.2 3.2 5.8e-06 26.3 0.4 3.5 3 0 0 3 3 3 3 PH domain PH_8 PF15409.6 ELR18698.1 - 3.3e-13 49.7 1.9 0.0003 21.0 0.0 3.9 3 0 0 3 3 3 3 Pleckstrin homology domain PH_9 PF15410.6 ELR18698.1 - 3.7e-10 40.2 7.9 0.0021 18.4 0.2 5.1 3 3 0 3 3 3 3 Pleckstrin homology domain PH_6 PF15406.6 ELR18698.1 - 5.7e-08 33.0 0.2 0.045 14.0 0.0 3.5 3 0 0 3 3 3 2 Pleckstrin homology domain PH_13 PF16652.5 ELR18698.1 - 1.6e-06 28.0 7.4 0.008 16.0 0.2 3.8 4 0 0 4 4 4 2 Pleckstrin homology domain PH_2 PF08458.10 ELR18698.1 - 1.8e-05 25.0 0.5 1.6 9.1 0.2 3.9 3 0 0 3 3 3 2 Plant pleckstrin homology-like region PH_17 PF18012.1 ELR18698.1 - 3.7e-05 23.3 1.5 0.068 12.9 0.0 3.5 3 0 0 3 3 3 1 PH domain PH_16 PF17838.1 ELR18698.1 - 0.08 12.8 0.8 7.5 6.4 0.0 3.5 4 0 0 4 4 4 0 PH domain Ribosomal_S10 PF00338.22 ELR18698.1 - 0.15 12.3 0.7 5.4 7.3 0.0 3.3 3 0 0 3 3 3 0 Ribosomal protein S10p/S20e Peptidase_M28 PF04389.17 ELR18699.1 - 5.5e-41 140.5 0.0 8e-41 139.9 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M28 PA PF02225.22 ELR18699.1 - 6.8e-09 35.6 0.7 2.4e-08 33.9 0.1 2.1 2 0 0 2 2 2 1 PA domain Peptidase_M20 PF01546.28 ELR18699.1 - 9e-07 28.8 0.0 3e-06 27.1 0.0 1.7 1 1 0 1 1 1 1 Peptidase family M20/M25/M40 VanW PF04294.13 ELR18699.1 - 0.017 14.8 0.0 0.04 13.6 0.0 1.6 1 0 0 1 1 1 0 VanW like protein SP_C-Propep PF08999.10 ELR18699.1 - 0.079 12.8 0.0 0.27 11.1 0.0 1.8 2 0 0 2 2 2 0 Surfactant protein C, N terminal propeptide DUF3379 PF11859.8 ELR18699.1 - 0.13 11.6 0.2 0.21 10.9 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3379) FYVE PF01363.21 ELR18700.1 - 1.7e-06 28.1 2.5 3.9e-06 26.9 2.5 1.6 1 0 0 1 1 1 1 FYVE zinc finger EI24 PF07264.11 ELR18701.1 - 3.3e-19 69.8 14.6 3.3e-19 69.8 14.6 1.8 2 0 0 2 2 2 1 Etoposide-induced protein 2.4 (EI24) PgaD PF13994.6 ELR18701.1 - 4.6 7.3 7.9 27 4.8 0.1 3.1 2 1 1 3 3 3 0 PgaD-like protein DUF2520 PF10728.9 ELR18702.1 - 0.017 14.9 0.6 0.03 14.1 0.6 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF2520) Mucin PF01456.17 ELR18703.1 - 2.2e-05 24.5 3.9 2.8e-05 24.2 3.9 1.1 1 0 0 1 1 1 1 Mucin-like glycoprotein BSP_II PF05432.11 ELR18703.1 - 0.055 13.2 8.4 0.068 12.9 8.4 1.1 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) Fungus-induced PF10917.8 ELR18703.1 - 0.062 13.6 0.4 0.11 12.8 0.4 1.4 1 0 0 1 1 1 0 Fungus-induced protein Thiolase_C PF02803.18 ELR18704.1 - 0.045 13.4 0.0 0.19 11.4 0.0 2.0 2 0 0 2 2 2 0 Thiolase, C-terminal domain IF4E PF01652.18 ELR18705.1 - 1.8e-58 196.8 0.1 2.2e-58 196.5 0.1 1.1 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E WWE PF02825.20 ELR18706.1 - 5.1e-13 49.4 3.1 1e-12 48.4 3.1 1.5 1 0 0 1 1 1 1 WWE domain MTS PF05175.14 ELR18708.1 - 9.9e-05 21.9 0.0 0.00012 21.7 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_25 PF13649.6 ELR18708.1 - 0.0025 18.5 0.0 0.0035 18.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 ELR18708.1 - 0.031 13.7 0.0 0.036 13.4 0.0 1.1 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_32 PF13679.6 ELR18708.1 - 0.046 13.7 0.0 0.051 13.6 0.0 1.1 1 0 0 1 1 1 0 Methyltransferase domain PCMT PF01135.19 ELR18708.1 - 0.068 12.9 0.0 0.083 12.6 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_16 PF10294.9 ELR18708.1 - 0.078 12.7 0.0 0.1 12.3 0.0 1.1 1 0 0 1 1 1 0 Lysine methyltransferase Methyltransf_12 PF08242.12 ELR18708.1 - 0.088 13.6 0.0 0.12 13.1 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain GidB PF02527.15 ELR18708.1 - 0.1 11.9 0.0 0.16 11.3 0.0 1.3 1 0 0 1 1 1 0 rRNA small subunit methyltransferase G Methyltransf_23 PF13489.6 ELR18708.1 - 0.13 12.0 0.0 0.16 11.8 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_31 PF13847.6 ELR18708.1 - 0.15 11.9 0.0 0.18 11.6 0.0 1.1 1 0 0 1 1 1 0 Methyltransferase domain FAM76 PF16046.5 ELR18709.1 - 0.01 15.2 2.7 0.013 14.8 2.7 1.1 1 0 0 1 1 1 0 FAM76 protein Prominin PF05478.11 ELR18709.1 - 0.46 8.4 1.3 0.61 8.0 1.3 1.1 1 0 0 1 1 1 0 Prominin MTS PF05175.14 ELR18710.1 - 0.026 14.1 0.0 0.031 13.8 0.0 1.1 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_16 PF10294.9 ELR18710.1 - 0.052 13.3 0.0 0.06 13.1 0.0 1.1 1 0 0 1 1 1 0 Lysine methyltransferase GidB PF02527.15 ELR18710.1 - 0.056 12.8 0.0 0.067 12.5 0.0 1.1 1 0 0 1 1 1 0 rRNA small subunit methyltransferase G PCMT PF01135.19 ELR18710.1 - 0.18 11.5 0.0 0.19 11.5 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) PAS_9 PF13426.7 ELR18711.1 - 0.0012 19.1 0.0 0.0025 18.0 0.0 1.5 1 0 0 1 1 1 1 PAS domain PAS_8 PF13188.7 ELR18711.1 - 0.011 15.8 0.0 0.036 14.1 0.0 1.8 2 0 0 2 2 2 0 PAS domain PAS PF00989.25 ELR18711.1 - 0.03 14.3 0.0 1.9 8.5 0.0 2.2 2 0 0 2 2 2 0 PAS fold PAS_3 PF08447.12 ELR18711.1 - 0.14 12.5 0.0 0.27 11.6 0.0 1.5 1 0 0 1 1 1 0 PAS fold zf-C4H2 PF10146.9 ELR18715.1 - 0.037 14.3 1.8 0.062 13.6 1.8 1.4 1 0 0 1 1 1 0 Zinc finger-containing protein Jnk-SapK_ap_N PF09744.9 ELR18715.1 - 0.13 12.5 10.9 0.33 11.2 10.9 1.6 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 Filament PF00038.21 ELR18715.1 - 0.26 10.8 10.2 0.43 10.1 10.2 1.3 1 0 0 1 1 1 0 Intermediate filament protein DUF5494 PF17598.2 ELR18715.1 - 0.26 11.4 2.3 1 9.5 0.2 2.6 1 1 0 2 2 2 0 Family of unknown function (DUF5494) ABC_tran_CTD PF16326.5 ELR18715.1 - 0.56 10.5 7.2 1.5 9.1 7.2 1.7 1 0 0 1 1 1 0 ABC transporter C-terminal domain PRKG1_interact PF15898.5 ELR18715.1 - 0.7 10.8 11.5 0.86 10.5 10.2 1.8 2 0 0 2 2 2 0 cGMP-dependent protein kinase interacting domain SR-25 PF10500.9 ELR18716.1 - 0.5 9.9 19.7 0.47 10.0 6.3 3.2 3 0 0 3 3 3 0 Nuclear RNA-splicing-associated protein Copine PF07002.16 ELR18717.1 - 2.9e-70 236.1 0.0 4.3e-70 235.6 0.0 1.2 1 0 0 1 1 1 1 Copine C2 PF00168.30 ELR18717.1 - 4.3e-24 84.8 0.1 2.8e-14 53.3 0.1 3.3 2 1 0 2 2 2 2 C2 domain vWA-TerF-like PF10138.9 ELR18717.1 - 0.00099 19.3 0.0 0.0017 18.5 0.0 1.4 1 0 0 1 1 1 1 vWA found in TerF C terminus SAM_2 PF07647.17 ELR18717.1 - 0.0022 18.1 0.0 0.005 16.9 0.0 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 ELR18717.1 - 0.026 15.0 0.1 0.065 13.7 0.0 1.6 2 0 0 2 2 2 0 SAM domain (Sterile alpha motif) SpoVIF PF14069.6 ELR18717.1 - 0.12 12.2 0.0 0.3 10.9 0.0 1.6 1 0 0 1 1 1 0 Stage VI sporulation protein F SOG2 PF10428.9 ELR18717.1 - 0.47 9.6 12.6 0.69 9.0 12.6 1.2 1 0 0 1 1 1 0 RAM signalling pathway protein TFIIA PF03153.13 ELR18717.1 - 0.77 9.7 27.8 1.5 8.8 27.8 1.5 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit FAM83 PF07894.12 ELR18717.1 - 5.8 6.4 8.4 10 5.5 8.4 1.4 1 0 0 1 1 1 0 FAM83 A-H G_path_suppress PF15991.5 ELR18717.1 - 7.3 6.6 35.9 14 5.7 35.9 1.4 1 0 0 1 1 1 0 G-protein pathway suppressor Ank_4 PF13637.6 ELR18718.1 - 6.1e-24 84.1 0.3 1.8e-14 53.9 0.1 3.3 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 ELR18718.1 - 5.6e-23 81.3 0.1 1.2e-12 48.3 0.1 2.4 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.30 ELR18718.1 - 8e-19 67.2 0.0 2.3e-06 27.8 0.0 4.5 4 0 0 4 4 4 3 Ankyrin repeat Ank_5 PF13857.6 ELR18718.1 - 6.3e-17 61.4 0.8 3.5e-10 39.9 0.1 3.6 2 1 1 4 4 4 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 ELR18718.1 - 1e-16 59.3 0.0 8.1e-06 25.8 0.0 4.3 4 0 0 4 4 4 3 Ankyrin repeat RhoGAP PF00620.27 ELR18719.1 - 6.6e-37 126.7 0.0 9.7e-37 126.1 0.0 1.2 1 0 0 1 1 1 1 RhoGAP domain Pro-NT_NN PF07421.11 ELR18719.1 - 0.037 14.3 0.0 0.058 13.6 0.0 1.2 1 0 0 1 1 1 0 Neurotensin/neuromedin N precursor zf-Tim10_DDP PF02953.15 ELR18720.1 - 3.6e-13 48.9 6.2 3.6e-13 48.9 6.2 1.5 2 0 0 2 2 2 1 Tim10/DDP family zinc finger VasI PF11319.8 ELR18720.1 - 0.02 14.6 0.5 0.024 14.3 0.5 1.1 1 0 0 1 1 1 0 Type VI secretion system VasI, EvfG, VC_A0118 TLP-20 PF06088.11 ELR18720.1 - 0.032 14.1 0.7 0.037 13.9 0.7 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus telokin-like protein-20 (TLP20) Zn_clus PF00172.18 ELR18722.1 - 5.9e-06 26.3 10.3 1.4e-05 25.1 10.3 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain PAS_9 PF13426.7 ELR18722.1 - 0.00024 21.3 0.0 0.00078 19.7 0.0 1.8 1 1 0 1 1 1 1 PAS domain AT_hook PF02178.19 ELR18722.1 - 0.17 11.8 6.7 0.62 10.1 6.7 2.1 1 0 0 1 1 1 0 AT hook motif PAS_3 PF08447.12 ELR18722.1 - 0.19 12.1 0.0 0.42 10.9 0.0 1.6 1 0 0 1 1 1 0 PAS fold KxDL PF10241.9 ELR18722.1 - 0.22 11.9 8.1 0.39 11.0 8.1 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein ADIP PF11559.8 ELR18722.1 - 0.25 11.4 11.7 0.38 10.8 11.7 1.2 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding PspA_IM30 PF04012.12 ELR18723.1 - 0.0017 18.0 3.3 0.0033 17.0 3.3 1.4 1 0 0 1 1 1 1 PspA/IM30 family Tmemb_cc2 PF10267.9 ELR18723.1 - 0.046 12.9 5.4 0.07 12.3 5.4 1.2 1 0 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein RAP1 PF07218.11 ELR18723.1 - 0.35 9.1 4.0 0.46 8.7 4.0 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) ADIP PF11559.8 ELR18723.1 - 2.1 8.4 8.4 4.2 7.4 8.4 1.4 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding ABC_tran_CTD PF16326.5 ELR18723.1 - 8.5 6.7 7.5 0.41 10.9 1.5 1.9 2 0 0 2 2 2 0 ABC transporter C-terminal domain PAS_8 PF13188.7 ELR18724.1 - 0.0078 16.2 0.0 0.019 15.0 0.0 1.6 1 0 0 1 1 1 1 PAS domain HAUS-augmin3 PF14932.6 ELR18724.1 - 0.033 13.8 4.8 0.071 12.7 4.8 1.5 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 3 PAS_9 PF13426.7 ELR18724.1 - 0.033 14.4 0.0 0.11 12.8 0.0 1.8 2 0 0 2 2 2 0 PAS domain DUF515 PF04415.12 ELR18724.1 - 0.13 10.6 0.7 0.24 9.8 0.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF515) Baculo_p24 PF05073.12 ELR18724.1 - 0.23 11.2 0.4 0.41 10.4 0.4 1.3 1 0 0 1 1 1 0 Baculovirus P24 capsid protein ABC_tran_CTD PF16326.5 ELR18724.1 - 0.28 11.4 5.0 0.77 10.1 5.0 1.8 1 0 0 1 1 1 0 ABC transporter C-terminal domain DUF1484 PF07363.11 ELR18724.1 - 0.3 12.1 4.0 1.6 9.8 4.0 2.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1484) DUF4106 PF13388.6 ELR18725.1 - 6.6 5.9 6.7 11 5.1 6.7 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4106) KAP PF05804.12 ELR18727.1 - 8.8e-05 20.9 0.0 0.00011 20.5 0.0 1.1 1 0 0 1 1 1 1 Kinesin-associated protein (KAP) IFRD PF05004.13 ELR18727.1 - 0.00045 19.4 1.4 0.00088 18.5 0.5 1.9 2 0 0 2 2 2 1 Interferon-related developmental regulator (IFRD) V-ATPase_H_N PF03224.14 ELR18727.1 - 0.0085 15.4 0.1 0.018 14.4 0.1 1.6 1 1 0 1 1 1 1 V-ATPase subunit H DUF3361 PF11841.8 ELR18727.1 - 0.032 14.2 0.0 0.08 12.9 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3361) U3snoRNP10 PF12397.8 ELR18727.1 - 0.056 13.8 0.3 2.2 8.7 0.0 2.6 1 1 0 2 2 2 0 U3 small nucleolar RNA-associated protein 10 DUF3791 PF12668.7 ELR18727.1 - 0.16 12.1 0.1 1.7 8.8 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3791) APC_rep PF18797.1 ELR18727.1 - 0.31 12.0 1.2 30 5.6 0.0 3.6 3 2 2 5 5 5 0 Adenomatous polyposis coli (APC) repeat Aldedh PF00171.22 ELR18728.1 - 3.6e-137 457.6 0.0 4.4e-137 457.4 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Rep_fac-A_C PF08646.10 ELR18729.1 - 2.9e-36 124.4 0.6 4.9e-36 123.7 0.1 1.7 2 0 0 2 2 2 1 Replication factor-A C terminal domain Rep-A_N PF04057.12 ELR18729.1 - 7e-22 77.4 0.0 2.1e-21 75.8 0.0 1.9 2 0 0 2 2 2 1 Replication factor-A protein 1, N-terminal domain REPA_OB_2 PF16900.5 ELR18729.1 - 5.4e-10 39.1 0.1 2.1e-07 30.8 0.0 3.1 2 1 0 2 2 2 1 Replication protein A OB domain tRNA_anti-codon PF01336.25 ELR18729.1 - 1.7e-07 31.1 0.3 7.9e-07 29.0 0.1 2.2 3 0 0 3 3 3 1 OB-fold nucleic acid binding domain DUF223 PF02721.14 ELR18729.1 - 0.011 16.1 0.1 0.02 15.1 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function DUF223 CDC24_OB3 PF17244.2 ELR18729.1 - 0.014 15.1 0.1 0.077 12.7 0.1 2.2 3 1 0 3 3 3 0 Cell division control protein 24, OB domain 3 DUF4539 PF15072.6 ELR18729.1 - 0.14 12.2 0.1 32 4.7 0.0 3.4 4 0 0 4 4 4 0 Domain of unknown function (DUF4539) BRCA-2_OB1 PF09103.10 ELR18729.1 - 0.17 11.9 0.0 0.36 10.8 0.0 1.5 1 0 0 1 1 1 0 BRCA2, oligonucleotide/oligosaccharide-binding, domain 1 PB1 PF00564.24 ELR18730.1 - 0.073 13.0 0.0 0.14 12.1 0.0 1.4 1 0 0 1 1 1 0 PB1 domain Dam PF05869.11 ELR18732.1 - 0.00018 21.1 0.1 0.00032 20.3 0.1 1.3 1 0 0 1 1 1 1 DNA N-6-adenine-methyltransferase (Dam) YppG PF14179.6 ELR18732.1 - 5.9 7.7 6.6 7.3 7.4 5.8 1.6 2 0 0 2 2 2 0 YppG-like protein DUF4614 PF15391.6 ELR18733.1 - 0.074 13.0 18.8 0.062 13.3 1.0 2.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4614) Peptidase_A21 PF03566.13 ELR18733.1 - 0.096 10.9 3.7 0.14 10.4 3.7 1.1 1 0 0 1 1 1 0 Peptidase family A21 SUR7 PF06687.12 ELR18734.1 - 0.66 9.6 16.8 0.019 14.6 6.1 2.7 2 1 1 3 3 3 0 SUR7/PalI family DUF202 PF02656.15 ELR18734.1 - 2.3 8.8 13.9 5.7 7.5 0.2 3.4 2 1 0 2 2 2 0 Domain of unknown function (DUF202) Kelch_5 PF13854.6 ELR18735.1 - 4.8e-14 52.0 0.0 1.2e-05 25.2 0.0 2.2 2 0 0 2 2 2 2 Kelch motif Kelch_1 PF01344.25 ELR18735.1 - 9.1e-11 41.2 0.0 1.9e-05 24.1 0.0 2.2 2 0 0 2 2 2 2 Kelch motif Kelch_3 PF13415.6 ELR18735.1 - 6e-10 39.2 2.3 4.8e-05 23.5 0.2 2.9 3 0 0 3 3 3 2 Galactose oxidase, central domain Kelch_2 PF07646.15 ELR18735.1 - 1.2e-08 34.6 0.3 0.0035 17.3 0.0 2.4 2 0 0 2 2 2 2 Kelch motif Kelch_6 PF13964.6 ELR18735.1 - 1.4e-07 31.5 0.2 0.0033 17.6 0.1 2.2 2 0 0 2 2 2 2 Kelch motif Kelch_4 PF13418.6 ELR18735.1 - 3.1e-07 30.3 0.2 0.0025 17.8 0.0 2.4 2 0 0 2 2 2 2 Galactose oxidase, central domain PQQ_3 PF13570.6 ELR18735.1 - 0.23 12.0 1.3 0.74 10.4 0.6 2.2 2 1 0 2 2 2 0 PQQ-like domain Orn_Arg_deC_N PF02784.16 ELR18737.1 - 3.5e-07 29.9 0.0 4.1e-07 29.6 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, pyridoxal binding domain Vac14_Fig4_bd PF11916.8 ELR18739.1 - 3.8e-75 251.5 9.0 7.7e-75 250.5 9.0 1.6 1 0 0 1 1 1 1 Vacuolar protein 14 C-terminal Fig4p binding Vac14_Fab1_bd PF12755.7 ELR18739.1 - 2e-47 159.7 0.0 2.9e-41 140.0 0.0 3.8 3 0 0 3 3 3 2 Vacuolar 14 Fab1-binding region HEAT_EZ PF13513.6 ELR18739.1 - 5e-11 42.9 0.2 0.0095 16.4 0.0 4.8 5 0 0 5 5 4 3 HEAT-like repeat HEAT PF02985.22 ELR18739.1 - 4e-10 39.1 0.3 0.00067 19.7 0.0 4.8 4 0 0 4 4 4 2 HEAT repeat Cnd1 PF12717.7 ELR18739.1 - 1.9e-09 37.7 0.2 0.031 14.3 0.0 3.8 4 0 0 4 4 4 3 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 ELR18739.1 - 0.00011 22.5 0.5 2.5 8.5 0.0 4.7 5 0 0 5 5 4 1 HEAT repeats CLASP_N PF12348.8 ELR18739.1 - 0.00036 20.2 0.0 8.5 5.9 0.0 4.6 2 1 1 4 4 4 1 CLASP N terminal ParcG PF10274.9 ELR18739.1 - 0.0013 18.9 0.1 0.072 13.2 0.0 3.0 1 1 2 3 3 3 1 Parkin co-regulated protein RTP1_C1 PF10363.9 ELR18739.1 - 0.0056 16.9 0.0 4.1 7.6 0.0 3.6 2 2 1 3 3 3 1 Required for nuclear transport of RNA pol II C-terminus 1 Arm PF00514.23 ELR18739.1 - 0.0084 16.1 0.0 2.3 8.4 0.0 3.9 3 0 0 3 3 3 1 Armadillo/beta-catenin-like repeat RasGEF_N_2 PF14663.6 ELR18739.1 - 0.021 15.2 1.5 5.4 7.5 0.2 3.5 3 0 0 3 3 3 0 Rapamycin-insensitive companion of mTOR RasGEF_N domain DUF4197 PF13852.6 ELR18739.1 - 0.14 11.8 0.0 0.33 10.6 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4197) Mito_carr PF00153.27 ELR18740.1 - 1.6e-67 223.5 1.1 6.1e-24 83.8 0.1 3.0 2 1 1 3 3 3 3 Mitochondrial carrier protein Thioredoxin PF00085.20 ELR18741.1 - 1.6e-65 217.6 0.2 5.9e-33 112.9 0.1 2.3 2 0 0 2 2 2 2 Thioredoxin ERp29 PF07749.12 ELR18741.1 - 2.5e-20 73.2 1.0 4.2e-20 72.4 0.4 1.7 2 0 0 2 2 1 1 Endoplasmic reticulum protein ERp29, C-terminal domain OST3_OST6 PF04756.13 ELR18741.1 - 3.9e-17 62.5 0.0 4.1e-08 32.9 0.0 2.3 2 1 0 2 2 2 2 OST3 / OST6 family, transporter family Thioredoxin_2 PF13098.6 ELR18741.1 - 8.2e-14 52.0 0.6 9.3e-06 26.1 0.0 3.0 2 1 0 2 2 2 2 Thioredoxin-like domain Thioredoxin_8 PF13905.6 ELR18741.1 - 2.9e-09 37.1 0.1 0.021 15.1 0.0 3.7 2 2 2 4 4 4 2 Thioredoxin-like AhpC-TSA PF00578.21 ELR18741.1 - 8e-08 32.2 0.1 0.0089 15.9 0.0 2.4 2 0 0 2 2 2 2 AhpC/TSA family Thioredoxin_7 PF13899.6 ELR18741.1 - 1.5e-06 28.3 0.1 0.0086 16.2 0.0 2.5 2 0 0 2 2 2 2 Thioredoxin-like Thioredoxin_6 PF13848.6 ELR18741.1 - 1e-05 25.6 0.1 0.27 11.1 0.0 3.4 4 0 0 4 4 4 2 Thioredoxin-like domain Redoxin PF08534.10 ELR18741.1 - 3.2e-05 23.7 0.5 0.12 12.1 0.1 2.4 2 0 0 2 2 2 2 Redoxin HyaE PF07449.11 ELR18741.1 - 0.00011 22.1 0.0 0.13 12.2 0.0 2.8 3 0 0 3 3 3 2 Hydrogenase-1 expression protein HyaE Thioredoxin_9 PF14595.6 ELR18741.1 - 0.0005 19.8 0.0 1 9.2 0.0 2.6 3 0 0 3 3 3 2 Thioredoxin TraF PF13728.6 ELR18741.1 - 0.00077 19.3 0.0 1.4 8.6 0.0 2.3 2 0 0 2 2 2 2 F plasmid transfer operon protein Thioredoxin_3 PF13192.6 ELR18741.1 - 0.15 12.2 0.1 2.8 8.0 0.1 2.4 2 0 0 2 2 2 0 Thioredoxin domain RRM_9 PF18444.1 ELR18741.1 - 0.18 11.7 0.0 0.51 10.2 0.0 1.8 1 0 0 1 1 1 0 RNA recognition motif Peptidase_M1 PF01433.20 ELR18742.1 - 4.5e-47 160.4 0.0 6.7e-47 159.9 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M1 domain Leuk-A4-hydro_C PF09127.11 ELR18742.1 - 7e-40 135.6 0.0 1.4e-39 134.7 0.0 1.5 1 0 0 1 1 1 1 Leukotriene A4 hydrolase, C-terminal Peptidase_M1_N PF17900.1 ELR18742.1 - 4.4e-24 85.7 0.0 9.9e-24 84.5 0.0 1.6 1 1 0 1 1 1 1 Peptidase M1 N-terminal domain Voltage_CLC PF00654.20 ELR18743.1 - 1e-71 242.1 30.1 1.3e-71 241.7 23.9 2.0 1 1 1 2 2 2 2 Voltage gated chloride channel CBS PF00571.28 ELR18743.1 - 4.5e-07 30.2 0.0 0.00075 19.9 0.0 2.6 2 0 0 2 2 2 2 CBS domain Herpes_UL73 PF03554.13 ELR18743.1 - 1 9.4 4.7 3 7.9 0.5 2.7 2 0 0 2 2 2 0 UL73 viral envelope glycoprotein WD40 PF00400.32 ELR18744.1 - 7.1e-27 93.1 9.0 1.6e-05 25.6 0.1 6.5 6 0 0 6 6 6 6 WD domain, G-beta repeat ATG16 PF08614.11 ELR18744.1 - 3.4e-16 60.1 29.0 1.9e-15 57.6 25.6 2.6 2 1 0 2 2 2 1 Autophagy protein 16 (ATG16) ANAPC4_WD40 PF12894.7 ELR18744.1 - 4.7e-10 39.6 0.6 0.047 14.0 0.0 5.1 1 1 5 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ELR18744.1 - 2.3e-07 29.8 2.7 0.002 16.8 0.2 3.4 2 1 1 3 3 3 3 Nucleoporin Nup120/160 eIF2A PF08662.11 ELR18744.1 - 0.00032 20.6 0.1 0.42 10.5 0.0 3.3 1 1 1 3 3 3 1 Eukaryotic translation initiation factor eIF2A DUF4407 PF14362.6 ELR18744.1 - 0.0088 15.4 9.5 0.016 14.6 9.5 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4407) Cytochrom_D1 PF02239.16 ELR18744.1 - 0.037 12.6 0.0 0.19 10.2 0.0 1.9 2 0 0 2 2 2 0 Cytochrome D1 heme domain DUF641 PF04859.12 ELR18744.1 - 0.077 13.3 7.5 0.26 11.6 6.1 2.3 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) Cas_DxTHG PF09455.10 ELR18744.1 - 0.09 12.3 3.1 0.12 11.9 3.1 1.1 1 0 0 1 1 1 0 CRISPR-associated (Cas) DxTHG family Mod_r PF07200.13 ELR18744.1 - 0.21 11.7 14.1 0.53 10.4 13.7 1.8 1 1 0 1 1 1 0 Modifier of rudimentary (Mod(r)) protein APG6_N PF17675.1 ELR18744.1 - 1.6 9.3 23.1 4 8.0 7.8 2.3 1 1 0 2 2 2 0 Apg6 coiled-coil region Fez1 PF06818.15 ELR18744.1 - 4.5 7.7 15.3 6.2 7.2 14.6 1.5 1 1 0 1 1 1 0 Fez1 YabA PF06156.13 ELR18744.1 - 6.2 7.5 14.9 2.6 8.7 3.3 2.3 1 1 1 2 2 2 0 Initiation control protein YabA TPR_MLP1_2 PF07926.12 ELR18744.1 - 6.6 6.8 21.0 0.62 10.1 8.0 2.8 1 1 0 2 2 2 0 TPR/MLP1/MLP2-like protein ZapB PF06005.12 ELR18744.1 - 9.3 6.8 15.6 9.1 6.8 5.3 2.5 2 0 0 2 2 2 0 Cell division protein ZapB ubiquitin PF00240.23 ELR18745.1 - 4.1e-11 42.5 0.0 6.9e-11 41.7 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin family UQ_con PF00179.26 ELR18745.1 - 2e-09 37.2 0.0 3.3e-09 36.5 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Rad60-SLD_2 PF13881.6 ELR18745.1 - 0.12 12.5 0.0 0.51 10.5 0.0 2.0 2 0 0 2 2 2 0 Ubiquitin-2 like Rad60 SUMO-like COPIIcoated_ERV PF07970.12 ELR18746.1 - 4.3e-89 298.1 0.1 5.4e-89 297.8 0.1 1.1 1 0 0 1 1 1 1 Endoplasmic reticulum vesicle transporter ERGIC_N PF13850.6 ELR18746.1 - 2.7e-32 111.0 0.0 5.7e-32 109.9 0.0 1.5 1 0 0 1 1 1 1 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) NAD_Gly3P_dh_N PF01210.23 ELR18747.1 - 7.4e-47 159.2 0.1 1.7e-46 158.1 0.0 1.6 2 0 0 2 2 2 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus NAD_Gly3P_dh_C PF07479.14 ELR18747.1 - 2.3e-46 157.6 0.2 3.9e-46 156.8 0.2 1.4 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus MFS_1 PF07690.16 ELR18748.1 - 2.3e-20 72.9 22.5 5.5e-18 65.0 11.4 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 ELR18748.1 - 4e-11 42.1 2.7 4e-11 42.1 2.7 2.3 1 1 1 2 2 2 1 MFS/sugar transport protein Phage_holin_3_6 PF07332.11 ELR18748.1 - 0.073 13.1 0.0 0.073 13.1 0.0 3.1 3 0 0 3 3 3 0 Putative Actinobacterial Holin-X, holin superfamily III Diedel PF13164.6 ELR18749.1 - 0.0062 17.0 0.2 0.013 15.9 0.2 1.5 1 0 0 1 1 1 1 Diedel GAF PF01590.26 ELR18749.1 - 0.0079 16.8 0.0 0.02 15.5 0.0 1.6 1 0 0 1 1 1 1 GAF domain PC_rep PF01851.22 ELR18749.1 - 0.028 14.9 0.2 0.071 13.6 0.2 1.7 1 0 0 1 1 1 0 Proteasome/cyclosome repeat TMEM135_C_rich PF15982.5 ELR18749.1 - 0.056 14.0 0.0 0.2 12.2 0.0 1.8 2 0 0 2 2 2 0 N-terminal cysteine-rich region of Transmembrane protein 135 FeS_assembly_P PF01883.19 ELR18750.1 - 1.4e-12 47.6 0.0 3.3e-12 46.4 0.0 1.6 1 0 0 1 1 1 1 Iron-sulfur cluster assembly protein GAF PF01590.26 ELR18750.1 - 0.055 14.1 0.0 0.11 13.1 0.0 1.6 1 0 0 1 1 1 0 GAF domain HCO3_cotransp PF00955.21 ELR18751.1 - 4.1e-87 293.1 12.8 5e-60 203.8 0.9 2.7 1 1 1 2 2 2 2 HCO3- transporter family Ost5 PF05251.12 ELR18751.1 - 0.74 10.1 7.2 0.63 10.3 0.6 3.2 3 0 0 3 3 3 0 Oligosaccharyltransferase subunit 5 HATPase_c PF02518.26 ELR18752.1 - 1.2e-29 103.1 0.1 2e-28 99.1 0.0 2.5 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 ELR18752.1 - 6.6e-20 71.3 0.0 1.5e-19 70.2 0.0 1.6 1 0 0 1 1 1 1 Response regulator receiver domain HisKA PF00512.25 ELR18752.1 - 2.9e-18 65.6 0.5 1e-17 63.9 0.0 2.1 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain GAF PF01590.26 ELR18752.1 - 0.0026 18.4 0.1 0.1 13.2 0.0 2.9 2 1 0 2 2 2 1 GAF domain GFO_IDH_MocA PF01408.22 ELR18752.1 - 0.035 14.9 0.0 0.093 13.6 0.0 1.7 1 0 0 1 1 1 0 Oxidoreductase family, NAD-binding Rossmann fold DUF308 PF03729.13 ELR18752.1 - 0.075 13.4 6.0 0.092 13.1 4.8 1.8 1 1 0 1 1 1 0 Short repeat of unknown function (DUF308) HATPase_c PF02518.26 ELR18753.1 - 3.5e-29 101.6 0.0 7.5e-29 100.5 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 ELR18753.1 - 2.3e-22 79.3 0.1 1.1e-21 77.1 0.1 2.1 2 0 0 2 2 2 1 Response regulator receiver domain HisKA PF00512.25 ELR18753.1 - 6.8e-19 67.7 0.6 2.3e-18 66.0 0.0 2.2 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain GAF PF01590.26 ELR18753.1 - 0.0015 19.2 0.4 0.0055 17.3 0.4 2.0 1 1 0 1 1 1 1 GAF domain Apt1 PF10351.9 ELR18753.1 - 0.24 10.2 4.3 0.45 9.3 4.3 1.4 1 0 0 1 1 1 0 Golgi-body localisation protein domain FAM117 PF15388.6 ELR18753.1 - 0.49 9.8 15.7 1.1 8.6 15.7 1.5 1 0 0 1 1 1 0 Protein Family FAM117 SPX PF03105.19 ELR18753.1 - 6.5 6.6 13.0 0.32 10.9 7.1 1.7 3 0 0 3 3 3 0 SPX domain SR-25 PF10500.9 ELR18753.1 - 6.8 6.2 24.7 0.57 9.8 19.4 1.9 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein GLE1 PF07817.13 ELR18754.1 - 4.2e-63 212.9 0.2 9.3e-63 211.8 0.2 1.6 1 0 0 1 1 1 1 GLE1-like protein Peptidase_M41 PF01434.18 ELR18755.1 - 2.5e-68 229.7 0.0 3.5e-68 229.2 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M41 AAA PF00004.29 ELR18755.1 - 1.5e-42 145.2 0.0 3.8e-42 143.8 0.0 1.7 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 ELR18755.1 - 2e-13 49.9 0.1 7.5e-13 48.1 0.0 1.9 2 0 0 2 2 2 1 AAA+ lid domain FtsH_ext PF06480.15 ELR18755.1 - 5.9e-10 39.5 0.0 6.3e-09 36.2 0.0 2.2 2 0 0 2 2 2 1 FtsH Extracellular AAA_5 PF07728.14 ELR18755.1 - 0.00018 21.5 0.0 0.00092 19.2 0.0 2.2 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 ELR18755.1 - 0.00027 21.4 0.1 0.046 14.1 0.0 3.1 3 0 0 3 3 3 1 AAA ATPase domain AAA_22 PF13401.6 ELR18755.1 - 0.0007 19.9 0.8 0.25 11.6 0.1 3.1 3 0 0 3 3 3 1 AAA domain RuvB_N PF05496.12 ELR18755.1 - 0.0032 17.2 0.0 0.011 15.4 0.0 2.0 1 1 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain TIP49 PF06068.13 ELR18755.1 - 0.0033 16.7 0.0 0.0057 15.9 0.0 1.3 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_33 PF13671.6 ELR18755.1 - 0.024 14.8 0.0 0.05 13.8 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_2 PF07724.14 ELR18755.1 - 0.027 14.6 0.0 0.11 12.6 0.0 1.9 1 1 0 1 1 1 0 AAA domain (Cdc48 subfamily) IstB_IS21 PF01695.17 ELR18755.1 - 0.078 12.7 0.1 0.18 11.5 0.1 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein Mg_chelatase PF01078.21 ELR18755.1 - 0.11 11.8 0.3 0.21 10.9 0.3 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI Adaptin_N PF01602.20 ELR18756.1 - 5.2e-121 404.8 8.3 6.6e-121 404.4 8.3 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 ELR18756.1 - 6.1e-13 49.1 0.8 4.1e-09 36.7 0.1 2.7 1 1 1 2 2 2 2 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.22 ELR18756.1 - 0.00012 22.0 0.1 1.5 9.2 0.0 4.2 4 0 0 4 4 4 2 HEAT repeat RTP1_C1 PF10363.9 ELR18756.1 - 0.00037 20.7 0.7 1.1 9.4 0.1 3.3 3 0 0 3 3 3 2 Required for nuclear transport of RNA pol II C-terminus 1 AP4E_app_platf PF14807.6 ELR18756.1 - 0.01 16.2 0.5 0.026 14.9 0.5 1.7 1 0 0 1 1 1 0 Adaptin AP4 complex epsilon appendage platform Pkinase PF00069.25 ELR18757.1 - 1.3e-59 201.7 0.0 3.8e-59 200.2 0.0 1.9 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR18757.1 - 8.2e-43 146.6 0.0 1.7e-42 145.5 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase tRNA_m1G_MT PF01746.21 ELR18758.1 - 2.7e-15 56.6 0.0 9.7e-15 54.8 0.0 2.0 1 1 0 1 1 1 1 tRNA (Guanine-1)-methyltransferase Transglut_prok PF09017.10 ELR18758.1 - 0.027 13.8 0.0 0.036 13.4 0.0 1.2 1 0 0 1 1 1 0 Microbial transglutaminase Med19 PF10278.9 ELR18758.1 - 0.066 13.1 5.3 0.11 12.4 5.3 1.3 1 0 0 1 1 1 0 Mediator of RNA pol II transcription subunit 19 Peptidase_S49_N PF08496.10 ELR18758.1 - 1.8 8.6 5.3 3.6 7.6 5.3 1.5 1 0 0 1 1 1 0 Peptidase family S49 N-terminal AI-2E_transport PF01594.16 ELR18759.1 - 1.4e-35 123.0 36.5 5.8e-34 117.7 36.5 2.2 1 1 0 1 1 1 1 AI-2E family transporter Snf7 PF03357.21 ELR18760.1 - 2.9e-34 118.1 20.7 3.5e-34 117.9 20.7 1.0 1 0 0 1 1 1 1 Snf7 SNF2_N PF00176.23 ELR18761.1 - 1.6e-60 204.7 0.4 2.9e-58 197.3 0.1 2.3 1 1 1 2 2 2 2 SNF2 family N-terminal domain Helicase_C PF00271.31 ELR18761.1 - 3e-19 69.4 0.0 1.3e-18 67.4 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 ELR18761.1 - 5.3e-08 33.0 0.0 8.7e-08 32.4 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit WW PF00397.26 ELR18761.1 - 6e-08 32.6 6.2 1.1e-07 31.7 6.2 1.5 1 0 0 1 1 1 1 WW domain zf-C3HC4 PF00097.25 ELR18761.1 - 3.7e-07 29.9 11.6 6.8e-07 29.1 11.6 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 ELR18761.1 - 1.1e-06 28.4 9.5 1.8e-06 27.7 9.5 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ELR18761.1 - 2.3e-06 27.4 10.2 3.9e-06 26.7 10.2 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_2 PF13923.6 ELR18761.1 - 2.3e-06 27.3 12.7 4.6e-06 26.4 12.7 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) HIRAN PF08797.11 ELR18761.1 - 2.4e-06 27.4 0.0 5.5e-06 26.2 0.0 1.6 1 0 0 1 1 1 1 HIRAN domain zf-RING_2 PF13639.6 ELR18761.1 - 2.7e-06 27.6 11.8 5.2e-06 26.7 11.8 1.5 1 0 0 1 1 1 1 Ring finger domain Prok-RING_4 PF14447.6 ELR18761.1 - 3e-05 23.8 11.2 6.4e-05 22.7 11.2 1.6 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_UBOX PF13445.6 ELR18761.1 - 3.5e-05 23.7 12.4 8.8e-05 22.4 12.4 1.7 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_11 PF17123.5 ELR18761.1 - 0.02 14.7 5.6 0.046 13.5 5.6 1.7 1 0 0 1 1 1 0 RING-like zinc finger RHH_5 PF07878.11 ELR18761.1 - 0.022 14.7 0.2 0.062 13.2 0.2 1.8 1 0 0 1 1 1 0 CopG-like RHH_1 or ribbon-helix-helix domain, RHH_5 zf-rbx1 PF12678.7 ELR18761.1 - 0.04 14.2 7.8 0.095 13.0 7.8 1.6 1 0 0 1 1 1 0 RING-H2 zinc finger domain Peptidase_M3_N PF08439.10 ELR18761.1 - 0.04 14.2 0.0 0.1 12.9 0.0 1.7 1 0 0 1 1 1 0 Oligopeptidase F zf-C3HC4_4 PF15227.6 ELR18761.1 - 0.043 14.0 12.9 0.077 13.2 12.9 1.4 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING Rtf2 PF04641.12 ELR18761.1 - 0.07 12.5 0.1 0.2 11.0 0.1 1.8 1 1 0 1 1 1 0 Rtf2 RING-finger zf-ANAPC11 PF12861.7 ELR18761.1 - 0.088 12.9 4.3 0.21 11.7 4.3 1.6 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger DNA_binding_1 PF01035.20 ELR18761.1 - 0.14 12.3 0.1 0.31 11.2 0.1 1.6 1 0 0 1 1 1 0 6-O-methylguanine DNA methyltransferase, DNA binding domain zf-RING_6 PF14835.6 ELR18761.1 - 1.8 8.5 4.1 4.1 7.4 4.1 1.5 1 0 0 1 1 1 0 zf-RING of BARD1-type protein zf-Nse PF11789.8 ELR18761.1 - 1.9 8.4 6.6 6.6 6.6 6.6 2.0 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit cpYpsA PF12694.7 ELR18762.1 - 1.4e-09 37.9 0.0 1.7e-09 37.6 0.0 1.1 1 0 0 1 1 1 1 Circularly permutated YpsA SLOG family GTP_EFTU PF00009.27 ELR18763.1 - 6.2e-32 110.7 0.0 1.1e-31 109.9 0.0 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_IV PF03764.18 ELR18763.1 - 6.7e-27 93.7 0.0 1.6e-26 92.4 0.0 1.6 1 0 0 1 1 1 1 Elongation factor G, domain IV EFG_C PF00679.24 ELR18763.1 - 9.5e-14 51.2 0.0 2.1e-13 50.1 0.0 1.6 1 0 0 1 1 1 1 Elongation factor G C-terminus EFG_II PF14492.6 ELR18763.1 - 2.7e-11 43.4 0.0 6.2e-11 42.2 0.0 1.6 1 0 0 1 1 1 1 Elongation Factor G, domain II GTP_EFTU_D2 PF03144.25 ELR18763.1 - 9.5e-05 22.7 0.0 0.00019 21.7 0.0 1.5 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 ELR18763.1 - 0.01 15.9 0.0 0.024 14.7 0.0 1.6 1 1 0 1 1 1 0 50S ribosome-binding GTPase DUF4347 PF14252.6 ELR18763.1 - 0.21 11.4 0.2 0.97 9.3 0.1 2.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4347) adh_short PF00106.25 ELR18764.1 - 3.6e-31 108.2 0.0 1.6e-30 106.1 0.0 1.9 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ELR18764.1 - 5.6e-20 71.9 0.0 1.4e-19 70.6 0.0 1.6 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ELR18764.1 - 1.2e-06 28.6 0.0 2e-06 27.8 0.0 1.3 1 0 0 1 1 1 1 KR domain SAM_1 PF00536.30 ELR18764.1 - 9.4e-05 22.8 0.1 0.00019 21.8 0.1 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Epimerase PF01370.21 ELR18764.1 - 0.0041 16.6 0.1 2 7.8 0.0 2.1 2 0 0 2 2 2 2 NAD dependent epimerase/dehydratase family CbtA PF09490.10 ELR18765.1 - 0.014 15.2 0.1 0.014 15.2 0.1 1.0 1 0 0 1 1 1 0 Probable cobalt transporter subunit (CbtA) Sde2_N_Ubi PF13019.6 ELR18766.1 - 3.3e-29 101.8 1.9 3.3e-29 101.8 1.9 2.7 2 2 0 2 2 2 1 Silencing defective 2 N-terminal ubiquitin domain ubiquitin PF00240.23 ELR18766.1 - 0.00043 20.0 0.0 0.0027 17.4 0.0 2.1 2 0 0 2 2 2 1 Ubiquitin family CDC45 PF02724.14 ELR18766.1 - 0.12 10.7 15.1 0.14 10.4 15.1 1.1 1 0 0 1 1 1 0 CDC45-like protein CCDC71L PF15374.6 ELR18766.1 - 0.23 10.7 6.7 0.31 10.2 6.7 1.1 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 71L Nop14 PF04147.12 ELR18766.1 - 0.58 8.3 18.7 0.74 7.9 18.7 1.1 1 0 0 1 1 1 0 Nop14-like family DUF3761 PF12587.8 ELR18766.1 - 0.59 10.6 2.0 1.3 9.5 2.0 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF3761) Coilin_N PF15862.5 ELR18766.1 - 1.2 9.0 9.2 2 8.2 9.2 1.4 1 0 0 1 1 1 0 Coilin N-terminus UQ_con PF00179.26 ELR18767.1 - 1.8e-50 170.2 0.0 2.1e-50 170.0 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme BRO1 PF03097.18 ELR18768.1 - 3.7e-104 348.6 10.5 5.7e-104 348.0 10.5 1.3 1 0 0 1 1 1 1 BRO1-like domain ALIX_LYPXL_bnd PF13949.6 ELR18768.1 - 3.1e-72 243.4 2.9 7.9e-72 242.0 0.6 2.5 2 0 0 2 2 2 1 ALIX V-shaped domain binding to HIV Connexin50 PF03509.14 ELR18768.1 - 0.022 15.6 0.1 0.32 11.8 0.0 2.9 2 0 0 2 2 2 0 Gap junction alpha-8 protein (Cx50) RuvC PF02075.17 ELR18768.1 - 0.039 13.8 0.3 0.087 12.7 0.3 1.6 1 0 0 1 1 1 0 Crossover junction endodeoxyribonuclease RuvC Sec20 PF03908.13 ELR18768.1 - 0.22 11.4 1.3 2.3 8.2 0.0 3.1 3 0 0 3 3 3 0 Sec20 Oxidored_q6 PF01058.22 ELR18769.1 - 1.9e-24 86.0 0.2 2.4e-24 85.6 0.2 1.1 1 0 0 1 1 1 1 NADH ubiquinone oxidoreductase, 20 Kd subunit Rep_fac_C PF08542.11 ELR18770.1 - 4.9e-25 87.7 0.1 3.3e-24 85.1 0.1 2.3 2 0 0 2 2 2 1 Replication factor C C-terminal domain AAA PF00004.29 ELR18770.1 - 3.5e-13 50.1 0.0 6.2e-13 49.3 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DNA_pol3_delta2 PF13177.6 ELR18770.1 - 1.2e-11 44.7 0.1 1.2e-09 38.1 0.2 2.2 1 1 1 2 2 2 1 DNA polymerase III, delta subunit Mg_chelatase PF01078.21 ELR18770.1 - 2.8e-06 26.9 0.0 9.4e-05 21.9 0.0 2.3 1 1 1 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_16 PF13191.6 ELR18770.1 - 4.2e-06 27.2 0.1 0.002 18.5 0.0 2.4 1 1 1 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 ELR18770.1 - 7.9e-06 26.2 0.3 0.0054 17.0 0.1 2.7 2 1 0 2 2 1 1 AAA domain AAA_14 PF13173.6 ELR18770.1 - 1.8e-05 24.7 0.0 3.2e-05 24.0 0.0 1.4 1 0 0 1 1 1 1 AAA domain Rad17 PF03215.15 ELR18770.1 - 3.9e-05 23.7 0.0 8.9e-05 22.5 0.0 1.6 1 1 0 1 1 1 1 Rad17 P-loop domain AAA_5 PF07728.14 ELR18770.1 - 4.8e-05 23.4 0.0 0.00013 22.0 0.0 1.7 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_24 PF13479.6 ELR18770.1 - 0.00038 20.2 0.0 0.00074 19.3 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 ELR18770.1 - 0.00042 20.2 0.1 0.0007 19.5 0.1 1.4 1 1 0 1 1 1 1 AAA domain AAA_25 PF13481.6 ELR18770.1 - 0.00092 18.8 0.2 0.0055 16.3 0.2 2.2 2 1 0 2 2 2 1 AAA domain AAA_19 PF13245.6 ELR18770.1 - 0.0012 19.2 0.5 0.035 14.4 0.1 2.4 1 1 0 2 2 2 1 AAA domain Viral_helicase1 PF01443.18 ELR18770.1 - 0.0015 18.3 0.0 0.0024 17.6 0.0 1.3 1 0 0 1 1 1 1 Viral (Superfamily 1) RNA helicase AAA_30 PF13604.6 ELR18770.1 - 0.0017 18.1 0.2 0.0071 16.1 0.2 2.0 1 1 0 1 1 1 1 AAA domain RuvB_N PF05496.12 ELR18770.1 - 0.0036 17.1 0.0 0.013 15.3 0.0 2.0 1 1 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain DEAD PF00270.29 ELR18770.1 - 0.0073 16.1 0.3 0.42 10.3 0.0 2.5 1 1 0 2 2 2 1 DEAD/DEAH box helicase AAA_3 PF07726.11 ELR18770.1 - 0.011 15.6 0.0 0.019 14.8 0.0 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_assoc_2 PF16193.5 ELR18770.1 - 0.017 15.5 0.0 0.067 13.5 0.0 2.0 2 0 0 2 2 2 0 AAA C-terminal domain ABC_tran PF00005.27 ELR18770.1 - 0.02 15.4 0.0 0.055 14.0 0.0 1.7 1 1 0 1 1 1 0 ABC transporter TniB PF05621.11 ELR18770.1 - 0.02 14.3 0.1 1 8.8 0.0 2.3 2 0 0 2 2 2 0 Bacterial TniB protein RNA_helicase PF00910.22 ELR18770.1 - 0.048 14.0 0.0 0.19 12.2 0.0 1.9 1 1 0 1 1 1 0 RNA helicase NTPase_1 PF03266.15 ELR18770.1 - 0.055 13.4 0.2 0.43 10.5 0.0 2.1 1 1 0 2 2 2 0 NTPase IstB_IS21 PF01695.17 ELR18770.1 - 0.058 13.1 0.1 0.13 12.0 0.1 1.6 1 1 0 1 1 1 0 IstB-like ATP binding protein AAA_18 PF13238.6 ELR18770.1 - 0.07 13.7 0.0 0.17 12.4 0.0 1.7 2 0 0 2 2 1 0 AAA domain BCS1_N PF08740.11 ELR18771.1 - 4.3e-37 127.9 0.1 1.2e-36 126.4 0.1 1.7 1 0 0 1 1 1 1 BCS1 N terminal AAA PF00004.29 ELR18771.1 - 2.4e-18 66.8 0.0 4.5e-18 65.9 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 ELR18771.1 - 0.00053 19.8 0.0 0.0014 18.4 0.0 1.7 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_33 PF13671.6 ELR18771.1 - 0.0053 16.9 0.5 0.011 15.9 0.0 2.0 2 1 0 2 2 2 1 AAA domain TIP49 PF06068.13 ELR18771.1 - 0.0083 15.4 0.3 0.013 14.7 0.0 1.5 2 0 0 2 2 2 1 TIP49 P-loop domain PPV_E1_C PF00519.17 ELR18771.1 - 0.012 14.5 0.0 0.018 13.9 0.0 1.2 1 0 0 1 1 1 0 Papillomavirus helicase AAA_18 PF13238.6 ELR18771.1 - 0.021 15.3 1.1 0.31 11.6 0.0 2.8 3 0 0 3 3 3 0 AAA domain AAA_5 PF07728.14 ELR18771.1 - 0.026 14.5 0.0 0.4 10.7 0.0 2.5 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) RNA_helicase PF00910.22 ELR18771.1 - 0.027 14.9 0.0 0.091 13.2 0.0 1.9 2 0 0 2 2 2 0 RNA helicase IstB_IS21 PF01695.17 ELR18771.1 - 0.037 13.7 0.0 0.079 12.7 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_11 PF13086.6 ELR18771.1 - 0.043 13.6 2.0 1.4 8.6 0.0 2.3 2 0 0 2 2 2 0 AAA domain DUF815 PF05673.13 ELR18771.1 - 0.05 12.7 0.5 0.18 10.9 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF815) ATPase PF06745.13 ELR18771.1 - 0.08 12.3 0.1 0.37 10.1 0.0 2.0 2 0 0 2 2 2 0 KaiC AAA_16 PF13191.6 ELR18771.1 - 0.097 13.1 0.8 0.28 11.6 0.0 2.0 2 1 0 2 2 2 0 AAA ATPase domain DUF4211 PF13926.6 ELR18772.1 - 1.1e-17 64.4 0.0 1.1e-17 64.4 0.0 3.1 3 0 0 3 3 3 1 Domain of unknown function (DUF4211) Ras PF00071.22 ELR18773.1 - 3.2e-40 137.4 0.0 2e-19 69.8 0.0 2.1 1 1 1 2 2 2 2 Ras family Roc PF08477.13 ELR18773.1 - 6.9e-22 77.9 0.0 2.1e-19 69.9 0.0 2.3 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR18773.1 - 5.2e-06 26.0 0.1 0.0002 20.8 0.0 2.1 1 1 0 2 2 2 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 ELR18773.1 - 0.00023 20.8 1.1 5.8 6.4 0.0 3.3 1 1 1 3 3 3 3 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 ELR18773.1 - 0.0011 19.0 0.0 0.0017 18.5 0.0 1.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 ELR18773.1 - 0.0071 15.9 0.0 0.32 10.5 0.0 2.2 2 1 0 2 2 2 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 ELR18773.1 - 0.031 14.2 0.0 1.3 8.9 0.0 2.1 2 0 0 2 2 2 0 RsgA GTPase AAA_24 PF13479.6 ELR18773.1 - 0.057 13.1 0.2 1.6 8.4 0.0 2.3 1 1 1 2 2 2 0 AAA domain AAA_22 PF13401.6 ELR18773.1 - 0.058 13.7 0.0 0.6 10.4 0.0 2.2 1 1 0 1 1 1 0 AAA domain TniB PF05621.11 ELR18773.1 - 0.075 12.4 0.0 0.13 11.6 0.0 1.4 1 0 0 1 1 1 0 Bacterial TniB protein Dynamin_N PF00350.23 ELR18773.1 - 0.17 11.9 0.0 0.24 11.4 0.0 1.5 1 1 0 1 1 1 0 Dynamin family RRM_1 PF00076.22 ELR18774.1 - 7.5e-08 32.1 0.0 9.7e-08 31.7 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 ELR18774.1 - 0.061 13.5 0.1 0.077 13.1 0.1 1.1 1 0 0 1 1 1 0 RNA recognition motif SMC_N PF02463.19 ELR18776.1 - 4.1e-29 101.6 0.2 4.7e-29 101.4 0.2 1.0 1 0 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 ELR18776.1 - 2.5e-13 51.0 0.3 3e-13 50.7 0.3 1.0 1 0 0 1 1 1 1 AAA domain AAA_21 PF13304.6 ELR18776.1 - 7.7e-07 29.2 0.2 8.8e-07 29.0 0.2 1.1 1 0 0 1 1 1 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 ELR18776.1 - 1.4e-05 24.7 0.0 2.8e-05 23.7 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_15 PF13175.6 ELR18776.1 - 1.9e-05 24.6 0.1 1.9e-05 24.5 0.1 1.1 1 0 0 1 1 1 1 AAA ATPase domain ABC_tran PF00005.27 ELR18776.1 - 0.053 14.0 0.5 0.07 13.6 0.5 1.4 1 1 0 1 1 1 0 ABC transporter DUF2813 PF11398.8 ELR18776.1 - 0.082 12.1 0.0 0.085 12.1 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2813) PDDEXK_1 PF12705.7 ELR18777.1 - 0.012 15.6 0.0 0.02 14.8 0.0 1.3 1 1 0 1 1 1 0 PD-(D/E)XK nuclease superfamily DUF3446 PF11928.8 ELR18777.1 - 0.024 15.0 3.0 0.024 15.0 3.0 4.6 3 1 1 4 4 4 0 Early growth response N-terminal domain Cas_Cas4 PF01930.17 ELR18777.1 - 0.027 14.6 0.7 0.27 11.3 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function DUF83 2_5_RNA_ligase2 PF13563.6 ELR18779.1 - 6.2e-30 104.1 0.2 6.2e-30 104.1 0.2 1.4 2 0 0 2 2 2 1 2'-5' RNA ligase superfamily LigT_PEase PF02834.16 ELR18779.1 - 0.00018 21.6 1.6 0.011 15.9 0.1 2.6 2 1 1 3 3 3 2 LigT like Phosphoesterase RRM_1 PF00076.22 ELR18780.1 - 7.3e-08 32.1 0.2 3.1e-06 26.9 0.2 2.2 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nop10p PF04135.12 ELR18781.1 - 5.3e-25 87.2 0.6 6.4e-25 86.9 0.6 1.1 1 0 0 1 1 1 1 Nucleolar RNA-binding protein, Nop10p family Myotub-related PF06602.14 ELR18783.1 - 2e-109 365.8 0.0 5.2e-109 364.4 0.0 1.6 1 1 0 1 1 1 1 Myotubularin-like phosphatase domain Ebp2 PF05890.12 ELR18784.1 - 8.1e-32 110.8 0.0 8.9e-32 110.7 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic rRNA processing protein EBP2 rve PF00665.26 ELR18785.1 - 2.7e-11 43.7 0.1 4.6e-11 42.9 0.1 1.4 1 1 0 1 1 1 1 Integrase core domain Retrotran_gag_2 PF14223.6 ELR18786.1 - 0.00013 21.6 0.0 0.0003 20.5 0.0 1.5 2 0 0 2 2 2 1 gag-polypeptide of LTR copia-type zf-C2H2_10 PF16588.5 ELR18786.1 - 0.046 13.5 0.8 0.11 12.3 0.8 1.6 1 0 0 1 1 1 0 C2H2 zinc-finger DUF4219 PF13961.6 ELR18786.1 - 0.068 12.8 0.1 0.19 11.4 0.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4219) zf-CCHC PF00098.23 ELR18786.1 - 0.19 11.9 2.1 0.44 10.7 2.1 1.6 1 0 0 1 1 1 0 Zinc knuckle Exo_endo_phos PF03372.23 ELR18788.1 - 0.0023 17.5 0.1 0.0025 17.3 0.1 1.1 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Ribosomal_60s PF00428.19 ELR18789.1 - 0.027 15.1 7.8 0.13 12.9 7.8 2.2 1 0 0 1 1 1 0 60s Acidic ribosomal protein Pkinase_Tyr PF07714.17 ELR18791.1 - 2.6e-55 187.5 0.0 4e-55 186.9 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ELR18791.1 - 1.7e-50 171.9 0.0 2.1e-50 171.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain EGF_2 PF07974.13 ELR18791.1 - 7.5e-05 23.0 13.9 0.00014 22.2 13.9 1.5 1 0 0 1 1 1 1 EGF-like domain FTA2 PF13095.6 ELR18791.1 - 0.0022 17.6 0.0 0.082 12.5 0.0 2.1 1 1 1 2 2 2 1 Kinetochore Sim4 complex subunit FTA2 ABC1 PF03109.16 ELR18791.1 - 0.0047 17.1 0.1 0.02 15.0 0.0 2.2 2 1 0 2 2 2 1 ABC1 family TMEM154 PF15102.6 ELR18791.1 - 0.028 14.3 0.0 0.046 13.6 0.0 1.3 1 0 0 1 1 1 0 TMEM154 protein family PBP_like_2 PF12849.7 ELR18791.1 - 0.041 13.6 0.0 0.061 13.0 0.0 1.2 1 0 0 1 1 1 0 PBP superfamily domain EGF_Tenascin PF18720.1 ELR18791.1 - 0.062 13.4 5.3 0.13 12.3 5.3 1.5 1 0 0 1 1 1 0 Tenascin EGF domain Kinase-like PF14531.6 ELR18791.1 - 0.069 12.4 0.0 0.18 11.1 0.0 1.6 2 0 0 2 2 2 0 Kinase-like RIO1 PF01163.22 ELR18791.1 - 0.14 11.7 0.3 0.43 10.2 0.1 1.7 1 1 1 2 2 2 0 RIO1 family SKG6 PF08693.10 ELR18791.1 - 3.9 7.0 6.3 0.49 9.8 0.2 2.3 2 0 0 2 2 2 0 Transmembrane alpha-helix domain Hid1 PF12722.7 ELR18792.1 - 2.4e-24 85.6 0.0 2.6e-24 85.4 0.0 1.0 1 0 0 1 1 1 1 High-temperature-induced dauer-formation protein Dymeclin PF09742.9 ELR18792.1 - 2.3e-18 66.0 0.0 2.7e-18 65.8 0.0 1.0 1 0 0 1 1 1 1 Dyggve-Melchior-Clausen syndrome protein Pmp3 PF01679.17 ELR18793.1 - 1.9e-19 69.6 10.5 2.1e-19 69.4 10.5 1.0 1 0 0 1 1 1 1 Proteolipid membrane potential modulator TMEMspv1-c74-12 PF11044.8 ELR18793.1 - 4 7.5 7.6 4.5 7.3 1.5 2.3 2 0 0 2 2 2 0 Plectrovirus spv1-c74 ORF 12 transmembrane protein Cep57_CLD_2 PF14197.6 ELR18794.1 - 0.00086 19.3 5.6 0.11 12.6 0.9 2.1 2 0 0 2 2 2 2 Centrosome localisation domain of PPC89 TPR_MLP1_2 PF07926.12 ELR18794.1 - 0.0034 17.4 5.2 0.0035 17.4 5.2 1.0 1 0 0 1 1 1 1 TPR/MLP1/MLP2-like protein ADIP PF11559.8 ELR18794.1 - 0.015 15.4 7.9 0.017 15.2 7.9 1.0 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding DUF5595 PF18077.1 ELR18794.1 - 0.018 15.1 0.5 2.2 8.4 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF5595) Lectin_N PF03954.14 ELR18794.1 - 0.058 13.1 0.9 0.065 13.0 0.9 1.1 1 0 0 1 1 1 0 Hepatic lectin, N-terminal domain HALZ PF02183.18 ELR18794.1 - 0.099 12.9 6.1 2.2 8.6 0.0 2.7 3 0 0 3 3 3 0 Homeobox associated leucine zipper DUF4407 PF14362.6 ELR18794.1 - 0.11 11.8 3.1 0.11 11.8 3.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Fungal_TACC PF12709.7 ELR18794.1 - 0.13 12.8 5.1 0.2 12.1 1.3 2.0 1 1 1 2 2 2 0 Fungal Transforming acidic coiled-coil (TACC) proteins Csm1_N PF18504.1 ELR18794.1 - 0.17 12.3 6.9 0.21 11.9 1.6 2.1 1 1 1 2 2 2 0 Csm1 N-terminal domain CENP-H PF05837.12 ELR18794.1 - 0.5 10.8 6.4 0.19 12.2 1.8 1.9 1 1 1 2 2 2 0 Centromere protein H (CENP-H) Rhodanese PF00581.20 ELR18795.1 - 1.3e-14 54.6 0.0 1.7e-14 54.2 0.0 1.2 1 0 0 1 1 1 1 Rhodanese-like domain DUF3394 PF11874.8 ELR18795.1 - 0.022 14.5 0.0 0.093 12.4 0.0 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF3394) Hid1 PF12722.7 ELR18796.1 - 5.2e-66 223.4 0.0 5.8e-66 223.2 0.0 1.0 1 0 0 1 1 1 1 High-temperature-induced dauer-formation protein Dymeclin PF09742.9 ELR18796.1 - 6.3e-55 186.8 0.0 7.1e-55 186.6 0.0 1.0 1 0 0 1 1 1 1 Dyggve-Melchior-Clausen syndrome protein Pmp3 PF01679.17 ELR18797.1 - 5.7e-19 68.1 11.8 1e-18 67.2 11.8 1.4 1 0 0 1 1 1 1 Proteolipid membrane potential modulator ATP-synt_F PF01990.17 ELR18797.1 - 5.9e-19 68.2 0.0 7.4e-19 67.9 0.0 1.2 1 0 0 1 1 1 1 ATP synthase (F/14-kDa) subunit SSXT PF05030.12 ELR18797.1 - 0.0049 16.5 0.0 0.0089 15.6 0.0 1.4 1 0 0 1 1 1 1 SSXT protein (N-terminal region) DUF3810 PF12725.7 ELR18797.1 - 0.077 12.3 0.0 0.092 12.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3810) TMEM154 PF15102.6 ELR18798.1 - 0.12 12.3 0.0 0.43 10.5 0.0 1.9 1 1 0 1 1 1 0 TMEM154 protein family SPX PF03105.19 ELR18798.1 - 0.24 11.3 7.6 0.37 10.7 7.6 1.3 1 0 0 1 1 1 0 SPX domain SOG2 PF10428.9 ELR18798.1 - 0.28 10.3 12.4 0.38 9.9 12.4 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein Cofilin_ADF PF00241.20 ELR18799.1 - 6.1e-08 32.5 0.0 1.5e-07 31.3 0.0 1.6 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein TPR_1 PF00515.28 ELR18800.1 - 4.8e-28 95.8 9.7 9.6e-05 22.0 0.0 6.3 7 0 0 7 7 7 5 Tetratricopeptide repeat TPR_2 PF07719.17 ELR18800.1 - 1.5e-25 87.2 10.7 0.00046 20.1 0.1 7.2 7 0 0 7 7 7 5 Tetratricopeptide repeat TPR_11 PF13414.6 ELR18800.1 - 3.6e-12 45.8 9.8 0.00094 18.8 0.0 5.7 6 1 1 7 7 7 3 TPR repeat TPR_8 PF13181.6 ELR18800.1 - 4.1e-10 39.1 5.4 0.045 14.0 0.1 6.4 5 2 1 6 6 6 3 Tetratricopeptide repeat TPR_14 PF13428.6 ELR18800.1 - 9.9e-08 32.2 16.0 0.29 12.1 1.4 6.4 3 3 3 6 6 6 3 Tetratricopeptide repeat TPR_16 PF13432.6 ELR18800.1 - 1.8e-07 31.7 15.8 0.25 12.0 0.7 4.9 2 2 2 5 5 5 4 Tetratricopeptide repeat TPR_9 PF13371.6 ELR18800.1 - 1.9e-07 31.1 13.2 0.26 11.4 2.8 4.5 3 2 2 5 5 4 4 Tetratricopeptide repeat TPR_19 PF14559.6 ELR18800.1 - 7.5e-06 26.4 11.8 0.019 15.5 0.0 4.9 2 2 3 5 5 5 2 Tetratricopeptide repeat TPR_17 PF13431.6 ELR18800.1 - 9.3e-06 25.7 7.5 0.028 14.8 0.0 5.5 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_12 PF13424.6 ELR18800.1 - 8.4e-05 22.8 16.0 0.043 14.1 2.0 5.2 3 3 2 5 5 5 1 Tetratricopeptide repeat TPR_6 PF13174.6 ELR18800.1 - 0.001 19.5 7.5 1.5 9.6 0.4 4.9 4 1 1 5 5 5 2 Tetratricopeptide repeat ANAPC3 PF12895.7 ELR18800.1 - 0.0074 16.5 4.1 1.3 9.3 0.5 3.9 2 2 0 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 PF13176.6 ELR18800.1 - 0.0088 16.0 3.6 36 4.7 0.7 5.5 5 1 0 5 5 5 0 Tetratricopeptide repeat BTAD PF03704.17 ELR18800.1 - 0.028 14.9 13.8 0.11 12.9 2.1 3.0 2 1 1 3 3 3 0 Bacterial transcriptional activator domain TBK1_ULD PF18396.1 ELR18800.1 - 0.14 12.1 0.1 0.36 10.8 0.1 1.6 1 0 0 1 1 1 0 TANK binding kinase 1 ubiquitin-like domain NBD_C PF17042.5 ELR18800.1 - 2 8.9 4.6 3.6 8.1 2.4 2.2 2 0 0 2 2 2 0 Nucleotide-binding C-terminal domain zf-AN1 PF01428.16 ELR18802.1 - 1.1e-11 44.7 8.3 2e-11 43.8 8.3 1.4 1 0 0 1 1 1 1 AN1-like Zinc finger Porin_3 PF01459.22 ELR18802.1 - 2.9e-06 27.0 0.0 4.4e-06 26.3 0.0 1.2 1 0 0 1 1 1 1 Eukaryotic porin Transp_Tc5_C PF04236.15 ELR18802.1 - 0.0076 16.6 1.8 0.014 15.8 1.8 1.4 1 0 0 1 1 1 1 Tc5 transposase C-terminal domain MDM10 PF12519.8 ELR18802.1 - 0.043 12.7 0.2 0.064 12.1 0.2 1.4 1 1 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 IBR PF01485.21 ELR18802.1 - 0.36 11.1 5.0 0.75 10.1 5.0 1.5 1 0 0 1 1 1 0 IBR domain, a half RING-finger domain Sec6 PF06046.13 ELR18803.1 - 2.9e-83 280.2 14.5 1.6e-76 258.0 9.3 2.4 3 0 0 3 3 3 2 Exocyst complex component Sec6 HR1 PF02185.16 ELR18803.1 - 2.8 8.1 6.6 2.9 8.1 0.2 3.3 2 1 1 3 3 3 0 Hr1 repeat BRCT PF00533.26 ELR18804.1 - 1.8e-05 25.0 0.0 3.2e-05 24.2 0.0 1.4 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain DUF4062 PF13271.6 ELR18804.1 - 3.8e-05 24.0 0.0 0.00011 22.5 0.0 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF4062) TIG PF01833.24 ELR18804.1 - 0.00041 20.4 0.1 0.00068 19.7 0.1 1.4 1 0 0 1 1 1 1 IPT/TIG domain PTCB-BRCT PF12738.7 ELR18804.1 - 0.00049 20.0 0.2 0.00088 19.2 0.2 1.4 1 0 0 1 1 1 1 twin BRCT domain BRCT_2 PF16589.5 ELR18804.1 - 0.0022 18.4 0.0 0.0043 17.4 0.0 1.4 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain Actin PF00022.19 ELR18805.1 - 5.6e-72 242.6 0.0 2.2e-71 240.6 0.0 1.7 1 1 0 1 1 1 1 Actin Ribosomal_L3 PF00297.22 ELR18806.1 - 7.6e-25 87.7 0.2 9.3e-23 80.8 0.3 2.3 1 1 1 2 2 2 2 Ribosomal protein L3 FbpA PF05833.11 ELR18808.1 - 5e-42 144.2 7.5 7.8e-35 120.5 0.1 2.6 3 0 0 3 3 3 2 Fibronectin-binding protein A N-terminus (FbpA) NFACT-R_1 PF05670.13 ELR18808.1 - 1.2e-24 87.1 0.4 9.7e-24 84.1 0.0 2.7 2 1 0 2 2 2 1 NFACT protein RNA binding domain DUF5590 PF17881.1 ELR18808.1 - 0.018 15.1 0.0 0.12 12.5 0.0 2.5 1 1 0 1 1 1 0 Domain of unknown function (DUF5590) Sec23_trunk PF04811.15 ELR18809.1 - 1.6e-72 244.0 0.0 2.5e-72 243.4 0.0 1.3 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_helical PF04815.15 ELR18809.1 - 1.7e-28 98.4 0.4 3.4e-28 97.5 0.4 1.5 1 0 0 1 1 1 1 Sec23/Sec24 helical domain Sec23_BS PF08033.12 ELR18809.1 - 3.2e-18 66.3 0.0 5.5e-18 65.5 0.0 1.4 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain zf-Sec23_Sec24 PF04810.15 ELR18809.1 - 5e-17 61.7 3.4 9.5e-17 60.8 3.4 1.5 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Gelsolin PF00626.22 ELR18809.1 - 4.4e-07 29.7 0.0 8.1e-07 28.9 0.0 1.4 1 0 0 1 1 1 1 Gelsolin repeat VWA PF00092.28 ELR18809.1 - 0.026 14.8 0.0 0.064 13.5 0.0 1.6 1 1 0 1 1 1 0 von Willebrand factor type A domain VWA_2 PF13519.6 ELR18809.1 - 0.063 13.9 0.1 2.6 8.8 0.1 2.6 1 1 0 1 1 1 0 von Willebrand factor type A domain Ribosomal_L7Ae PF01248.26 ELR18810.1 - 4.6e-25 87.2 1.3 5.8e-25 86.9 1.3 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family OTU PF02338.19 ELR18811.1 - 3.1e-13 50.3 0.0 6.4e-13 49.3 0.0 1.5 1 0 0 1 1 1 1 OTU-like cysteine protease DUF2052 PF09747.9 ELR18811.1 - 7.2 6.7 31.0 0.8 9.8 8.2 3.3 3 0 0 3 3 3 0 Coiled-coil domain containing protein (DUF2052) GCV_T PF01571.21 ELR18812.1 - 1.3e-05 24.7 0.0 2e-05 24.1 0.0 1.2 1 0 0 1 1 1 1 Aminomethyltransferase folate-binding domain zf-4CXXC_R1 PF10497.9 ELR18813.1 - 2.9e-36 123.7 10.0 6.8e-36 122.5 10.0 1.7 1 0 0 1 1 1 1 Zinc-finger domain of monoamine-oxidase A repressor R1 BORA_N PF15280.6 ELR18813.1 - 0.038 13.7 0.1 0.079 12.6 0.1 1.5 1 0 0 1 1 1 0 Protein aurora borealis N-terminus TipE PF16972.5 ELR18813.1 - 6.7 5.8 12.5 0.028 13.6 3.3 1.6 2 0 0 2 2 2 0 Na+ channel auxiliary subunit TipE PPP4R2 PF09184.11 ELR18814.1 - 0.0066 16.1 7.9 0.17 11.4 1.9 2.2 2 0 0 2 2 2 2 PPP4R2 PBP1_TM PF14812.6 ELR18814.1 - 0.0093 16.3 13.5 0.0093 16.3 13.5 2.5 2 0 0 2 2 2 1 Transmembrane domain of transglycosylase PBP1 at N-terminal KORA PF16509.5 ELR18814.1 - 0.012 15.8 0.0 0.025 14.9 0.0 1.4 1 0 0 1 1 1 0 TrfB plasmid transcriptional repressor Afi1 PF07792.12 ELR18814.1 - 0.056 13.9 5.5 0.66 10.5 1.5 2.3 2 0 0 2 2 2 0 Docking domain of Afi1 for Arf3 in vesicle trafficking YL1 PF05764.13 ELR18814.1 - 0.4 10.8 16.0 0.54 10.3 5.8 2.4 2 0 0 2 2 2 0 YL1 nuclear protein Nucleo_P87 PF07267.11 ELR18814.1 - 0.96 8.2 5.3 0.42 9.4 1.4 1.9 2 0 0 2 2 2 0 Nucleopolyhedrovirus capsid protein P87 IHABP4_N PF16174.5 ELR18814.1 - 1.3 9.6 17.7 3.3 8.3 5.9 2.3 2 0 0 2 2 2 0 Intracellular hyaluronan-binding protein 4 N-terminal Pox_Ag35 PF03286.14 ELR18814.1 - 1.4 8.6 7.3 11 5.7 0.1 2.2 2 0 0 2 2 2 0 Pox virus Ag35 surface protein PTPRCAP PF15713.5 ELR18814.1 - 1.8 8.8 12.8 2.1 8.6 0.7 2.3 2 0 0 2 2 2 0 Protein tyrosine phosphatase receptor type C-associated Cwf_Cwc_15 PF04889.12 ELR18814.1 - 3.7 7.2 18.7 1.3 8.7 5.4 2.2 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein Peroxin-3 PF04882.12 ELR18815.1 - 1.8e-38 132.8 0.1 8.9e-35 120.6 0.2 2.9 1 1 1 2 2 2 2 Peroxin-3 DUF810 PF05664.11 ELR18815.1 - 0.093 11.3 0.0 0.13 10.8 0.0 1.1 1 0 0 1 1 1 0 Plant family of unknown function (DUF810) Exo_endo_phos PF03372.23 ELR18816.1 - 5.4e-10 39.2 0.0 1.2e-09 38.0 0.0 1.6 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family TIM21 PF08294.11 ELR18817.1 - 1.5e-19 70.3 0.0 1.9e-19 70.0 0.0 1.1 1 0 0 1 1 1 1 TIM21 Coa1 PF08695.10 ELR18817.1 - 0.039 13.7 0.0 0.077 12.7 0.0 1.5 1 0 0 1 1 1 0 Cytochrome oxidase complex assembly protein 1 BTB PF00651.31 ELR18818.1 - 6.5e-18 65.0 0.0 2.2e-15 56.8 0.0 2.6 1 1 1 2 2 2 2 BTB/POZ domain PP2C_2 PF13672.6 ELR18819.1 - 0.00029 20.5 0.0 0.4 10.3 0.0 2.3 2 0 0 2 2 2 2 Protein phosphatase 2C fn3_PAP PF17808.1 ELR18820.1 - 1e-36 125.6 0.3 5e-36 123.4 0.3 2.1 1 1 0 1 1 1 1 Fn3-like domain from Purple Acid Phosphatase Pur_ac_phosph_N PF16656.5 ELR18820.1 - 1.2e-19 70.6 0.0 3.6e-19 69.1 0.0 1.9 1 0 0 1 1 1 1 Purple acid Phosphatase, N-terminal domain Metallophos PF00149.28 ELR18820.1 - 1.4e-17 64.9 0.3 2.6e-17 64.0 0.3 1.5 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_C PF14008.6 ELR18820.1 - 4.7e-11 43.4 1.3 1.5e-09 38.6 0.2 2.8 2 0 0 2 2 2 1 Iron/zinc purple acid phosphatase-like protein C Ank PF00023.30 ELR18822.1 - 5.4e-08 32.9 0.0 1.5e-07 31.5 0.0 1.8 1 0 0 1 1 1 1 Ankyrin repeat Ank_2 PF12796.7 ELR18822.1 - 1.2e-07 32.2 0.0 2.5e-07 31.2 0.0 1.5 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 ELR18822.1 - 1.9e-07 30.8 0.0 7.2e-07 29.0 0.0 2.0 1 0 0 1 1 1 1 Ankyrin repeat WD40 PF00400.32 ELR18822.1 - 6.5e-07 29.9 6.5 0.38 11.7 0.0 5.5 5 0 0 5 5 5 2 WD domain, G-beta repeat Ank_5 PF13857.6 ELR18822.1 - 8.9e-06 25.9 0.0 2.1e-05 24.7 0.0 1.6 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_4 PF13637.6 ELR18822.1 - 2.9e-05 24.5 0.0 0.00015 22.3 0.0 2.1 1 1 1 2 2 2 1 Ankyrin repeats (many copies) T-box PF00907.22 ELR18822.1 - 0.13 12.5 0.1 0.2 11.9 0.1 1.2 1 0 0 1 1 1 0 T-box AXH PF08517.12 ELR18823.1 - 0.044 14.3 3.5 0.093 13.3 3.5 1.5 1 0 0 1 1 1 0 Ataxin-1 and HBP1 module (AXH) DDHD PF02862.17 ELR18823.1 - 0.19 11.9 9.5 0.18 12.0 2.8 2.2 2 0 0 2 2 2 0 DDHD domain SRP-alpha_N PF04086.13 ELR18823.1 - 0.19 11.6 24.7 0.15 12.0 14.1 2.1 2 0 0 2 2 2 0 Signal recognition particle, alpha subunit, N-terminal DUF1168 PF06658.12 ELR18823.1 - 1.3 8.8 31.0 4.5 7.1 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1168) DUF853 PF05872.12 ELR18823.1 - 3 6.3 6.0 5.3 5.5 6.0 1.3 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF853) Striatin PF08232.12 ELR18823.1 - 4.3 7.9 24.6 1.1 9.9 13.2 2.3 2 0 0 2 2 2 0 Striatin family NARP1 PF12569.8 ELR18823.1 - 8.5 5.2 27.1 0.67 8.8 21.9 1.6 2 0 0 2 2 2 0 NMDA receptor-regulated protein 1 PPL5 PF18168.1 ELR18823.1 - 8.8 5.5 11.6 18 4.5 11.6 1.4 1 0 0 1 1 1 0 Prim-pol family 5 MBOAT PF03062.19 ELR18824.1 - 1.9e-31 109.7 22.6 2.7e-31 109.2 22.6 1.3 1 0 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family MBOAT_2 PF13813.6 ELR18824.1 - 0.00015 21.9 4.9 0.00039 20.6 4.9 1.7 1 0 0 1 1 1 1 Membrane bound O-acyl transferase family SPT_ssu-like PF11779.8 ELR18825.1 - 3.9e-06 26.4 2.1 4.6e-06 26.1 2.1 1.2 1 0 0 1 1 1 1 Small subunit of serine palmitoyltransferase-like Motilin_ghrelin PF04644.12 ELR18826.1 - 0.015 15.1 1.6 0.023 14.5 1.6 1.3 1 0 0 1 1 1 0 Motilin/ghrelin Ribonuc_L-PSP PF01042.21 ELR18829.1 - 1.2e-33 115.6 0.0 3e-17 62.8 0.0 3.5 3 0 0 3 3 3 3 Endoribonuclease L-PSP SnoaL_2 PF12680.7 ELR18831.1 - 1.5e-13 51.2 0.2 1.9e-13 50.9 0.2 1.1 1 0 0 1 1 1 1 SnoaL-like domain SnoaL_3 PF13474.6 ELR18831.1 - 0.0073 16.6 0.1 0.01 16.1 0.1 1.1 1 0 0 1 1 1 1 SnoaL-like domain SnoaL PF07366.12 ELR18831.1 - 0.016 15.0 0.0 0.021 14.6 0.0 1.2 1 0 0 1 1 1 0 SnoaL-like polyketide cyclase SchA_CurD PF04486.12 ELR18831.1 - 0.049 13.7 0.0 0.062 13.4 0.0 1.2 1 0 0 1 1 1 0 SchA/CurD like domain zf-4CXXC_R1 PF10497.9 ELR18832.1 - 2.8e-27 94.9 10.9 2.8e-27 94.9 10.9 2.5 2 0 0 2 2 2 1 Zinc-finger domain of monoamine-oxidase A repressor R1 Chromo PF00385.24 ELR18832.1 - 8e-15 54.5 0.0 2.8e-14 52.7 0.0 2.1 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain TauE PF01925.19 ELR18833.1 - 7e-09 35.7 30.8 7e-09 35.7 30.8 2.0 1 1 1 2 2 2 2 Sulfite exporter TauE/SafE SPT6_acidic PF14632.6 ELR18833.1 - 0.26 11.9 6.0 0.41 11.3 6.0 1.2 1 0 0 1 1 1 0 Acidic N-terminal SPT6 DUF3093 PF11292.8 ELR18833.1 - 0.27 11.5 4.1 1.1 9.5 0.0 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF3093) Rad51 PF08423.11 ELR18834.1 - 1.4e-38 132.6 0.2 4.8e-38 130.9 0.2 1.6 1 1 0 1 1 1 1 Rad51 ATPase PF06745.13 ELR18834.1 - 3.2e-09 36.5 0.1 5e-09 35.8 0.1 1.3 1 0 0 1 1 1 1 KaiC AAA_25 PF13481.6 ELR18834.1 - 8.2e-06 25.5 0.0 1.8e-05 24.4 0.0 1.6 1 1 0 1 1 1 1 AAA domain DnaB_C PF03796.15 ELR18834.1 - 0.00072 19.0 0.0 0.0013 18.1 0.0 1.4 1 0 0 1 1 1 1 DnaB-like helicase C terminal domain ATP-synt_ab PF00006.25 ELR18834.1 - 0.051 13.2 0.3 8.7 5.9 0.2 2.3 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain AAA_24 PF13479.6 ELR18834.1 - 0.12 12.1 0.0 0.28 10.9 0.0 1.6 1 1 0 1 1 1 0 AAA domain AAA_33 PF13671.6 ELR18834.1 - 0.12 12.5 0.0 0.36 11.0 0.0 1.8 1 0 0 1 1 1 0 AAA domain RasGAP PF00616.19 ELR18835.1 - 1.5e-19 70.6 0.0 8.4e-19 68.1 0.0 2.0 1 1 0 1 1 1 1 GTPase-activator protein for Ras-like GTPase Laminin_G_3 PF13385.6 ELR18835.1 - 1.2e-16 61.2 0.8 1.2e-16 61.2 0.8 2.1 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Ig_3 PF13927.6 ELR18835.1 - 0.095 13.3 0.1 0.32 11.6 0.1 2.0 1 0 0 1 1 1 0 Immunoglobulin domain RabGAP-TBC PF00566.18 ELR18836.1 - 3e-26 92.4 0.0 1.4e-25 90.2 0.0 1.9 1 1 0 1 1 1 1 Rab-GTPase-TBC domain PARP PF00644.20 ELR18837.1 - 8.9e-17 61.3 0.0 8.5e-15 54.9 0.0 2.3 1 1 1 2 2 2 2 Poly(ADP-ribose) polymerase catalytic domain FHA_2 PF17913.1 ELR18837.1 - 1.1e-08 35.1 0.0 2.4e-08 34.1 0.0 1.5 1 0 0 1 1 1 1 FHA domain HBS1_N PF08938.10 ELR18837.1 - 0.0015 18.8 0.3 0.02 15.2 0.1 2.5 2 0 0 2 2 2 1 HBS1 N-terminus DUF1296 PF06972.11 ELR18837.1 - 0.034 14.3 0.1 0.079 13.1 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1296) CUE PF02845.16 ELR18837.1 - 0.034 13.9 0.0 0.065 13.0 0.0 1.4 1 0 0 1 1 1 0 CUE domain ASCH PF04266.14 ELR18839.1 - 0.012 16.2 0.0 0.02 15.5 0.0 1.3 1 0 0 1 1 1 0 ASCH domain DUF3128 PF11326.8 ELR18840.1 - 1.8e-10 41.1 3.7 2.5e-10 40.6 3.7 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3128) AMP-binding PF00501.28 ELR18841.1 - 5.9e-103 344.7 0.0 8.5e-103 344.2 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 ELR18841.1 - 5.3e-11 43.3 0.3 3.1e-09 37.7 0.1 2.8 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain Ion_trans PF00520.31 ELR18842.1 - 8.7e-28 97.2 52.7 2.4e-13 49.9 20.4 3.2 2 1 1 3 3 3 3 Ion transport protein AP3D1 PF06375.11 ELR18842.1 - 0.0053 17.0 0.5 0.01 16.1 0.5 1.4 1 0 0 1 1 1 1 AP-3 complex subunit delta-1 EF-hand_7 PF13499.6 ELR18842.1 - 0.038 14.4 0.0 0.1 13.1 0.0 1.7 1 0 0 1 1 1 0 EF-hand domain pair ELO PF01151.18 ELR18844.1 - 9.7e-47 159.6 8.1 1.2e-46 159.3 8.1 1.0 1 0 0 1 1 1 1 GNS1/SUR4 family Ras PF00071.22 ELR18845.1 - 6.5e-25 87.6 0.0 1e-24 87.0 0.0 1.3 1 0 0 1 1 1 1 Ras family F-box-like PF12937.7 ELR18845.1 - 3.5e-10 39.6 1.0 7.6e-10 38.5 1.0 1.6 1 0 0 1 1 1 1 F-box-like Ank_4 PF13637.6 ELR18845.1 - 3.9e-10 40.1 0.0 3.2e-06 27.6 0.0 2.6 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 ELR18845.1 - 8.6e-10 39.1 0.0 1.7e-09 38.1 0.0 1.4 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 ELR18845.1 - 1.3e-08 34.9 0.2 3.5e-08 33.6 0.2 1.8 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank PF00023.30 ELR18845.1 - 2.2e-08 34.2 0.0 0.00095 19.5 0.0 3.5 3 0 0 3 3 3 1 Ankyrin repeat Roc PF08477.13 ELR18845.1 - 7e-08 32.7 0.0 1.3e-07 31.8 0.0 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ank_3 PF13606.6 ELR18845.1 - 2.7e-07 30.3 0.0 0.0032 17.8 0.0 3.5 3 0 0 3 3 3 2 Ankyrin repeat F-box PF00646.33 ELR18845.1 - 6e-07 29.2 0.6 1.1e-06 28.3 0.6 1.5 1 0 0 1 1 1 1 F-box domain Arf PF00025.21 ELR18845.1 - 0.067 12.7 0.0 0.14 11.6 0.0 1.5 1 0 0 1 1 1 0 ADP-ribosylation factor family DUF772 PF05598.11 ELR18845.1 - 0.089 12.8 0.0 0.29 11.2 0.0 1.8 1 0 0 1 1 1 0 Transposase domain (DUF772) FAD_binding_1 PF00667.20 ELR18846.1 - 6.2e-27 94.6 0.0 1.7e-26 93.2 0.0 1.6 1 1 0 1 1 1 1 FAD binding domain NAD_binding_1 PF00175.21 ELR18846.1 - 2.1e-10 41.2 0.0 3.6e-09 37.2 0.0 2.8 2 1 0 2 2 2 1 Oxidoreductase NAD-binding domain Oxidored-like PF09791.9 ELR18846.1 - 1.9e-07 30.6 4.1 5.6e-07 29.1 4.1 1.8 1 0 0 1 1 1 1 Oxidoreductase-like protein, N-terminal Clathrin PF00637.20 ELR18847.1 - 1.1e-189 621.9 48.1 4.9e-33 114.0 1.1 8.1 8 0 0 8 8 8 7 Region in Clathrin and VPS Clathrin_propel PF01394.20 ELR18847.1 - 1.3e-34 116.8 2.5 4.3e-06 26.8 0.0 6.8 6 0 0 6 6 6 6 Clathrin propeller repeat Clathrin_H_link PF13838.6 ELR18847.1 - 1.5e-30 104.9 1.4 7.2e-29 99.5 0.3 3.1 2 0 0 2 2 2 1 Clathrin-H-link Clathrin-link PF09268.10 ELR18847.1 - 2.5e-10 39.5 0.6 7.4e-10 38.0 0.0 2.3 2 0 0 2 2 2 1 Clathrin, heavy-chain linker Tenui_NS4 PF03300.13 ELR18847.1 - 0.00018 21.0 0.1 0.0004 19.9 0.1 1.5 1 0 0 1 1 1 1 Tenuivirus non-structural, movement protein NS4 TPR_1 PF00515.28 ELR18847.1 - 0.00023 20.9 10.2 12 5.9 0.5 6.4 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_19 PF14559.6 ELR18847.1 - 0.00053 20.4 5.3 2.6 8.6 0.3 7.3 8 2 0 8 8 8 1 Tetratricopeptide repeat TPR_7 PF13176.6 ELR18847.1 - 0.0047 16.9 14.5 3.6 7.8 0.1 8.6 9 0 0 9 9 9 1 Tetratricopeptide repeat TPR_2 PF07719.17 ELR18847.1 - 0.013 15.5 15.0 21 5.5 0.4 7.3 8 0 0 8 8 8 0 Tetratricopeptide repeat Coatomer_WDAD PF04053.14 ELR18847.1 - 0.014 14.5 8.8 0.13 11.3 0.2 4.9 5 0 0 5 5 5 0 Coatomer WD associated region Vps39_1 PF10366.9 ELR18847.1 - 0.076 13.3 12.8 0.13 12.5 0.4 6.1 7 1 1 8 8 7 0 Vacuolar sorting protein 39 domain 1 TPR_8 PF13181.6 ELR18847.1 - 0.11 12.8 13.2 27 5.3 0.0 7.8 9 0 0 9 9 8 0 Tetratricopeptide repeat eIF-5a PF01287.20 ELR18848.1 - 1.8e-06 27.9 0.0 3e-06 27.2 0.0 1.3 1 0 0 1 1 1 1 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold RUN PF02759.19 ELR18849.1 - 5.8e-16 58.7 0.0 1.2e-15 57.7 0.0 1.5 1 1 0 1 1 1 1 RUN domain SAE2 PF08573.10 ELR18850.1 - 9e-08 33.2 3.1 1.7e-05 25.9 0.2 4.5 2 2 1 3 3 3 2 DNA repair protein endonuclease SAE2/CtIP C-terminus BUD22 PF09073.10 ELR18851.1 - 0.043 13.2 9.3 0.11 11.8 9.3 1.6 1 1 0 1 1 1 0 BUD22 PBP1_TM PF14812.6 ELR18851.1 - 0.078 13.4 10.7 1 9.7 4.3 2.7 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal RXT2_N PF08595.11 ELR18851.1 - 1.1 9.2 4.5 9.1 6.3 0.3 2.4 2 0 0 2 2 2 0 RXT2-like, N-terminal Nop14 PF04147.12 ELR18851.1 - 4.2 5.5 6.9 4 5.5 1.8 2.1 2 0 0 2 2 2 0 Nop14-like family DUF4746 PF15928.5 ELR18851.1 - 5.4 6.3 5.0 1.6 8.0 1.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4746) PALP PF00291.25 ELR18853.1 - 0.0015 18.0 0.0 0.0021 17.5 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Peptidase_C39_2 PF13529.6 ELR18854.1 - 4.8e-12 46.6 0.0 1.1e-11 45.5 0.0 1.6 1 1 0 1 1 1 1 Peptidase_C39 like family Peptidase_C70 PF12385.8 ELR18854.1 - 8.1e-09 35.6 0.0 5.1e-08 33.0 0.0 2.1 1 1 0 1 1 1 1 Papain-like cysteine protease AvrRpt2 DUF3335 PF11814.8 ELR18854.1 - 7.1e-05 22.4 0.0 0.00012 21.6 0.0 1.3 1 0 0 1 1 1 1 Peptidase_C39 like family Guanylate_cyc_2 PF09778.9 ELR18854.1 - 0.0036 16.7 0.0 0.15 11.4 0.0 2.3 2 1 1 3 3 3 1 Guanylylate cyclase Ras PF00071.22 ELR18855.1 - 4.1e-45 153.3 0.0 4.7e-45 153.1 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR18855.1 - 3.5e-27 95.0 0.0 4.7e-27 94.6 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR18855.1 - 6.7e-13 48.5 0.0 8.7e-13 48.1 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 ELR18855.1 - 1.4e-06 28.3 0.2 0.0011 19.0 0.0 2.1 2 0 0 2 2 2 2 RsgA GTPase Gtr1_RagA PF04670.12 ELR18855.1 - 0.0019 17.6 0.0 0.0026 17.2 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 ELR18855.1 - 0.0027 17.3 0.0 0.0038 16.8 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 ELR18855.1 - 0.003 17.6 0.0 0.0048 17.0 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase G-alpha PF00503.20 ELR18855.1 - 0.0038 16.4 0.3 0.039 13.1 0.1 2.1 1 1 1 2 2 2 1 G-protein alpha subunit AAA_14 PF13173.6 ELR18855.1 - 0.0057 16.7 0.0 0.008 16.2 0.0 1.3 1 0 0 1 1 1 1 AAA domain SRPRB PF09439.10 ELR18855.1 - 0.011 15.2 0.0 0.017 14.6 0.0 1.2 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit AAA_25 PF13481.6 ELR18855.1 - 0.012 15.2 0.2 0.023 14.2 0.2 1.5 1 1 0 1 1 1 0 AAA domain AAA_24 PF13479.6 ELR18855.1 - 0.032 14.0 0.0 0.032 13.9 0.0 1.2 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 ELR18855.1 - 0.039 14.3 2.8 0.5 10.7 2.8 2.1 1 1 0 1 1 1 0 AAA ATPase domain DAP3 PF10236.9 ELR18855.1 - 0.054 12.6 0.1 0.08 12.1 0.1 1.2 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 AAA_23 PF13476.6 ELR18855.1 - 0.055 14.0 0.0 0.069 13.6 0.0 1.2 1 0 0 1 1 1 0 AAA domain UDPGP PF01704.18 ELR18856.1 - 7.9e-189 627.5 0.4 9.4e-189 627.3 0.4 1.0 1 0 0 1 1 1 1 UTP--glucose-1-phosphate uridylyltransferase Phage_CI_C PF16452.5 ELR18856.1 - 0.057 13.7 0.1 0.35 11.2 0.1 2.3 2 0 0 2 2 2 0 Bacteriophage CI repressor C-terminal domain FPP PF05911.11 ELR18856.1 - 0.094 10.9 0.1 0.15 10.3 0.1 1.2 1 0 0 1 1 1 0 Filament-like plant protein, long coiled-coil SAM_1 PF00536.30 ELR18857.1 - 5.3e-09 36.4 0.0 8e-09 35.8 0.0 1.2 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 ELR18857.1 - 1.7e-05 24.8 0.0 2.6e-05 24.2 0.0 1.3 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) CAF-1_p150 PF11600.8 ELR18857.1 - 0.0035 17.1 19.2 0.0051 16.5 19.2 1.3 1 0 0 1 1 1 1 Chromatin assembly factor 1 complex p150 subunit, N-terminal RR_TM4-6 PF06459.12 ELR18857.1 - 0.055 13.3 15.6 0.073 12.9 15.6 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Fibrillarin_2 PF10113.9 ELR18857.1 - 0.075 11.6 2.8 0.1 11.2 2.8 1.1 1 0 0 1 1 1 0 Fibrillarin-like archaeal protein PTPRCAP PF15713.5 ELR18857.1 - 0.39 11.0 17.9 0.62 10.3 17.9 1.3 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated NPR3 PF03666.13 ELR18857.1 - 1.7 7.4 13.3 2.1 7.0 13.3 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 TFB6 PF17110.5 ELR18857.1 - 3.3 7.4 6.5 4.8 6.9 6.5 1.3 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH DUF4718 PF15842.5 ELR18857.1 - 7.9 6.2 9.5 8.6 6.1 8.5 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4718) Tim54 PF11711.8 ELR18857.1 - 8.5 5.0 16.1 12 4.6 16.1 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Rhodanese PF00581.20 ELR18858.1 - 1.3e-11 45.0 0.0 2.6e-11 44.0 0.0 1.5 1 0 0 1 1 1 1 Rhodanese-like domain Prenyltransf PF01255.19 ELR18859.1 - 1.4e-66 224.2 0.0 3e-66 223.2 0.0 1.5 1 1 0 1 1 1 1 Putative undecaprenyl diphosphate synthase DUF4726 PF15855.5 ELR18859.1 - 0.15 12.3 0.4 0.3 11.3 0.4 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4726) zf-RING_11 PF17123.5 ELR18860.1 - 0.0011 18.7 6.0 0.0021 17.8 6.0 1.5 1 0 0 1 1 1 1 RING-like zinc finger Zn_ribbon_17 PF17120.5 ELR18860.1 - 0.0015 18.1 2.2 0.0031 17.1 2.2 1.5 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type zf-RING_2 PF13639.6 ELR18860.1 - 0.002 18.4 10.2 0.002 18.4 10.2 2.0 2 1 0 2 2 1 1 Ring finger domain PHD PF00628.29 ELR18860.1 - 0.0043 16.9 6.5 0.0043 16.9 6.5 2.1 2 1 0 2 2 2 1 PHD-finger Prok-RING_1 PF14446.6 ELR18860.1 - 0.0063 16.4 1.0 0.0063 16.4 1.0 2.1 2 0 0 2 2 2 1 Prokaryotic RING finger family 1 Zf_RING PF16744.5 ELR18860.1 - 0.0073 16.4 3.9 0.016 15.3 3.9 1.5 1 0 0 1 1 1 1 KIAA1045 RING finger C1_1 PF00130.22 ELR18860.1 - 0.0075 16.1 2.6 0.0075 16.1 2.6 2.3 2 0 0 2 2 2 1 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-CpG_bind_C PF12269.8 ELR18860.1 - 0.031 14.1 2.1 0.049 13.4 2.1 1.2 1 0 0 1 1 1 0 CpG binding protein zinc finger C terminal domain OrfB_Zn_ribbon PF07282.11 ELR18860.1 - 0.72 9.8 7.2 10 6.2 0.5 2.7 2 0 0 2 2 2 0 Putative transposase DNA-binding domain PHD_4 PF16866.5 ELR18860.1 - 1 9.5 10.0 6.3 7.0 10.1 2.2 1 1 1 2 2 2 0 PHD-finger Ribosomal_L37ae PF01780.19 ELR18860.1 - 1.1 9.3 5.6 0.29 11.3 0.4 2.2 2 0 0 2 2 2 0 Ribosomal L37ae protein family FANCL_C PF11793.8 ELR18860.1 - 2.4 8.4 9.6 6.5 7.0 9.6 1.7 1 1 0 1 1 1 0 FANCL C-terminal domain zf-rbx1 PF12678.7 ELR18860.1 - 3.5 8.0 9.8 9.4 6.6 9.3 2.0 1 1 0 1 1 1 0 RING-H2 zinc finger domain R3H PF01424.22 ELR18861.1 - 1.8e-12 47.1 0.0 3.4e-12 46.2 0.0 1.5 1 0 0 1 1 1 1 R3H domain zf-RanBP PF00641.18 ELR18861.1 - 3.7e-05 23.0 3.9 0.00011 21.4 3.9 1.9 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others zf-NF-X1 PF01422.17 ELR18861.1 - 0.0021 18.1 7.0 0.0021 18.1 7.0 6.2 6 2 0 6 6 6 1 NF-X1 type zinc finger RNA_bind PF08675.11 ELR18861.1 - 0.19 11.8 0.0 0.36 10.9 0.0 1.4 1 0 0 1 1 1 0 RNA binding domain IKI3 PF04762.12 ELR18862.1 - 3e-242 806.6 0.0 2.4e-220 734.1 0.0 2.1 1 1 1 2 2 2 2 IKI3 family ANAPC4_WD40 PF12894.7 ELR18862.1 - 1.9e-05 24.9 0.0 0.0035 17.6 0.0 3.3 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain TPR_8 PF13181.6 ELR18862.1 - 0.0017 18.4 1.9 0.05 13.8 0.0 3.6 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_1 PF00515.28 ELR18862.1 - 0.015 15.1 0.4 1.2 9.1 0.0 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat SNAP PF14938.6 ELR18862.1 - 0.074 12.5 5.9 0.072 12.5 1.9 2.2 1 1 1 2 2 2 0 Soluble NSF attachment protein, SNAP TPR_11 PF13414.6 ELR18862.1 - 0.09 12.5 0.0 3.6 7.4 0.0 2.5 2 0 0 2 2 2 0 TPR repeat TPR_7 PF13176.6 ELR18862.1 - 0.13 12.4 1.1 12 6.2 0.1 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_2 PF07719.17 ELR18862.1 - 9.4 6.6 9.5 6.6 7.1 0.0 4.1 5 0 0 5 5 5 0 Tetratricopeptide repeat Complex1_LYR PF05347.15 ELR18863.1 - 4.7e-05 23.3 0.0 6.7e-05 22.9 0.0 1.3 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Peptidase_M20 PF01546.28 ELR18865.1 - 3.4e-23 82.5 0.0 4.5e-23 82.1 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 ELR18865.1 - 2.5e-11 43.4 0.0 6.4e-11 42.1 0.0 1.7 1 1 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M28 PF04389.17 ELR18865.1 - 0.057 13.1 0.0 0.091 12.4 0.0 1.3 1 0 0 1 1 1 0 Peptidase family M28 DUF4783 PF16022.5 ELR18865.1 - 0.21 11.8 0.0 0.4 10.9 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4783) Tom7 PF08038.12 ELR18866.1 - 1.5e-09 37.3 0.1 2e-09 37.0 0.1 1.2 1 0 0 1 1 1 1 TOM7 family Gln-synt_C-ter PF18318.1 ELR18867.1 - 2.3e-37 127.4 0.2 6.8e-37 125.9 0.3 1.7 2 0 0 2 2 2 1 Glutamine synthetase C-terminal domain Imm12 PF15560.6 ELR18867.1 - 0.12 12.4 0.0 0.4 10.6 0.0 1.9 2 0 0 2 2 2 0 Immunity protein 12 GSIII_N PF12437.8 ELR18868.1 - 2.7e-67 225.4 0.0 3.9e-67 224.9 0.0 1.2 1 0 0 1 1 1 1 Glutamine synthetase type III N terminal Gln-synt_C PF00120.24 ELR18868.1 - 1.8e-19 69.9 0.0 6.7e-19 68.1 0.0 1.8 2 0 0 2 2 2 1 Glutamine synthetase, catalytic domain PX PF00787.24 ELR18869.1 - 0.0018 18.2 0.5 0.0056 16.7 0.0 2.0 2 0 0 2 2 2 1 PX domain DIL PF01843.19 ELR18872.1 - 5.5e-17 62.0 0.0 2e-16 60.2 0.0 2.0 1 0 0 1 1 1 1 DIL domain DLH PF01738.18 ELR18873.1 - 6.6e-22 78.1 0.2 7.4e-22 78.0 0.2 1.0 1 0 0 1 1 1 1 Dienelactone hydrolase family Abhydrolase_3 PF07859.13 ELR18873.1 - 0.00073 19.4 0.2 0.002 18.0 0.0 1.6 1 1 1 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_2 PF02230.16 ELR18873.1 - 0.083 12.7 0.0 0.13 12.0 0.0 1.3 1 0 0 1 1 1 0 Phospholipase/Carboxylesterase DUF3530 PF12048.8 ELR18873.1 - 0.13 11.6 0.0 0.17 11.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3530) ABC_tran PF00005.27 ELR18874.1 - 2.9e-47 160.6 0.6 1.4e-22 80.7 0.0 3.1 3 0 0 3 3 3 2 ABC transporter AAA_21 PF13304.6 ELR18874.1 - 4.7e-18 66.0 1.8 7.1e-05 22.8 0.0 4.4 4 0 0 4 4 4 4 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 ELR18874.1 - 3e-09 36.7 2.5 0.0014 18.1 0.0 4.1 3 2 1 4 4 3 3 RecF/RecN/SMC N terminal domain AAA_15 PF13175.6 ELR18874.1 - 2.2e-08 34.2 2.3 0.07 12.8 0.2 4.4 4 0 0 4 4 4 3 AAA ATPase domain MMR_HSR1 PF01926.23 ELR18874.1 - 5.4e-08 32.9 0.0 0.00015 21.8 0.0 2.8 2 0 0 2 2 2 2 50S ribosome-binding GTPase ABC_tran_Xtn PF12848.7 ELR18874.1 - 1.2e-07 31.6 13.6 1.2e-07 31.6 13.6 4.0 4 0 0 4 4 3 1 ABC transporter RsgA_GTPase PF03193.16 ELR18874.1 - 9.9e-07 28.8 0.2 0.0058 16.6 0.0 2.9 2 1 0 2 2 2 2 RsgA GTPase AAA_29 PF13555.6 ELR18874.1 - 3e-06 26.9 0.1 0.012 15.4 0.0 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_16 PF13191.6 ELR18874.1 - 6.1e-06 26.7 1.3 0.06 13.7 0.0 2.9 3 1 0 3 3 2 2 AAA ATPase domain AAA_28 PF13521.6 ELR18874.1 - 5e-05 23.6 0.9 0.076 13.2 0.0 2.8 3 0 0 3 3 2 2 AAA domain NACHT PF05729.12 ELR18874.1 - 0.00014 21.8 0.1 0.15 11.9 0.0 2.6 2 0 0 2 2 2 2 NACHT domain Dynamin_N PF00350.23 ELR18874.1 - 0.00027 21.0 8.9 0.00066 19.8 0.0 3.9 4 1 0 4 4 4 1 Dynamin family AAA_33 PF13671.6 ELR18874.1 - 0.00032 20.9 3.7 0.25 11.5 0.0 3.7 4 0 0 4 4 3 2 AAA domain AAA_14 PF13173.6 ELR18874.1 - 0.00038 20.5 0.0 0.054 13.5 0.0 3.2 3 0 0 3 3 3 1 AAA domain AAA_25 PF13481.6 ELR18874.1 - 0.00042 20.0 0.1 4.8 6.7 0.0 4.0 3 1 0 3 3 3 1 AAA domain AAA PF00004.29 ELR18874.1 - 0.00072 20.0 0.1 3.6 8.0 0.0 3.6 3 1 0 3 3 2 2 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 ELR18874.1 - 0.0014 18.9 0.0 1.7 8.9 0.1 2.9 2 1 0 2 2 2 1 AAA domain RNA_helicase PF00910.22 ELR18874.1 - 0.002 18.5 0.0 4.5 7.7 0.0 2.8 2 0 0 2 2 2 2 RNA helicase Roc PF08477.13 ELR18874.1 - 0.009 16.2 0.0 3.9 7.7 0.0 2.7 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase NB-ARC PF00931.22 ELR18874.1 - 0.0099 15.1 0.2 6.2 5.9 0.0 3.0 3 0 0 3 3 3 0 NB-ARC domain SbcCD_C PF13558.6 ELR18874.1 - 0.011 16.0 0.0 0.45 10.8 0.1 3.2 2 1 0 2 2 2 0 Putative exonuclease SbcCD, C subunit DUF87 PF01935.17 ELR18874.1 - 0.013 15.6 0.8 13 5.8 0.0 3.3 3 0 0 3 3 3 0 Helicase HerA, central domain AAA_24 PF13479.6 ELR18874.1 - 0.015 15.0 0.9 4.3 7.0 0.0 2.8 3 0 0 3 3 3 0 AAA domain AAA_18 PF13238.6 ELR18874.1 - 0.016 15.8 0.3 11 6.6 0.0 3.2 3 1 0 3 3 2 0 AAA domain AAA_5 PF07728.14 ELR18874.1 - 0.016 15.2 0.0 2.4 8.2 0.0 2.8 3 0 0 3 3 2 0 AAA domain (dynein-related subfamily) AAA_23 PF13476.6 ELR18874.1 - 0.028 14.9 0.1 0.028 14.9 0.1 4.4 4 1 1 5 5 4 0 AAA domain cobW PF02492.19 ELR18874.1 - 0.028 14.0 0.7 3.4 7.2 0.1 2.7 3 0 0 3 3 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_27 PF13514.6 ELR18874.1 - 0.056 13.0 2.5 5.7 6.5 0.0 3.2 3 0 0 3 3 3 0 AAA domain FeoB_N PF02421.18 ELR18874.1 - 0.078 12.5 1.2 0.2 11.2 0.0 2.2 3 0 0 3 3 2 0 Ferrous iron transport protein B SRP54 PF00448.22 ELR18874.1 - 0.27 10.8 4.2 11 5.6 0.0 3.5 4 0 0 4 4 3 0 SRP54-type protein, GTPase domain DUF4140 PF13600.6 ELR18874.1 - 1.3 9.5 5.8 10 6.7 0.5 3.1 2 0 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) Ank_2 PF12796.7 ELR18875.1 - 1.6e-17 63.9 0.3 0.0017 18.9 0.0 5.1 4 1 1 5 5 5 4 Ankyrin repeats (3 copies) WWE PF02825.20 ELR18875.1 - 1.3e-12 48.1 0.3 4.3e-12 46.4 0.3 1.9 1 0 0 1 1 1 1 WWE domain Ank_3 PF13606.6 ELR18875.1 - 2e-11 43.0 1.5 0.023 15.2 0.0 5.5 6 0 0 6 6 4 2 Ankyrin repeat Ank PF00023.30 ELR18875.1 - 2.1e-11 43.7 2.4 0.00087 19.6 0.0 4.6 4 0 0 4 4 3 3 Ankyrin repeat Ank_5 PF13857.6 ELR18875.1 - 5e-11 42.6 0.3 0.02 15.2 0.0 5.2 5 0 0 5 5 5 3 Ankyrin repeats (many copies) BTB PF00651.31 ELR18875.1 - 6.2e-09 36.1 5.0 6.1e-07 29.6 1.2 2.6 2 0 0 2 2 2 2 BTB/POZ domain Ank_4 PF13637.6 ELR18875.1 - 4.1e-07 30.4 1.6 0.23 12.1 0.0 4.8 4 1 1 5 5 5 2 Ankyrin repeats (many copies) Vps39_1 PF10366.9 ELR18875.1 - 0.0083 16.4 0.6 0.026 14.8 0.1 2.1 2 0 0 2 2 2 1 Vacuolar sorting protein 39 domain 1 TPR_1 PF00515.28 ELR18875.1 - 0.023 14.5 0.9 6.9 6.7 0.2 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_2 PF07719.17 ELR18875.1 - 0.094 12.9 5.5 2.9 8.2 0.1 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat Inhibitor_I34 PF10466.9 ELR18875.1 - 0.16 12.6 0.8 0.52 11.0 0.8 1.8 1 0 0 1 1 1 0 Saccharopepsin inhibitor I34 Pantoate_transf PF02548.15 ELR18876.1 - 1.9e-106 355.2 0.3 2.4e-106 354.9 0.3 1.1 1 0 0 1 1 1 1 Ketopantoate hydroxymethyltransferase RIBIOP_C PF04950.12 ELR18877.1 - 5.9e-118 393.5 0.0 8.5e-118 393.0 0.0 1.2 1 0 0 1 1 1 1 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal AARP2CN PF08142.12 ELR18877.1 - 2.7e-19 69.0 0.0 1.4e-18 66.8 0.0 2.2 2 0 0 2 2 2 1 AARP2CN (NUC121) domain COMM_domain PF07258.14 ELR18878.1 - 2.1e-11 43.8 0.2 4.3e-11 42.8 0.2 1.5 1 0 0 1 1 1 1 COMM domain BRCA-2_OB3 PF09104.10 ELR18878.1 - 0.0053 16.4 0.2 0.013 15.2 0.1 1.7 2 0 0 2 2 2 1 BRCA2, oligonucleotide/oligosaccharide-binding, domain 3 Asp_Arg_Hydrox PF05118.15 ELR18879.1 - 6.7e-14 52.0 0.1 4.8e-09 36.2 0.0 2.6 2 0 0 2 2 2 2 Aspartyl/Asparaginyl beta-hydroxylase DUF1990 PF09348.10 ELR18881.1 - 3.1e-40 137.7 0.4 5.2e-40 137.0 0.4 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1990) LRR_6 PF13516.6 ELR18882.1 - 1.4e-16 59.1 34.6 0.00068 19.5 0.1 8.5 9 0 0 9 9 9 6 Leucine Rich repeat SAPS PF04499.15 ELR18882.1 - 4.9e-12 45.4 3.9 4.5e-11 42.2 0.2 2.7 3 0 0 3 3 3 2 SIT4 phosphatase-associated protein tRNA-synt_1 PF00133.22 ELR18883.1 - 0.082 11.1 0.1 1.3 7.2 0.1 2.1 2 0 0 2 2 2 0 tRNA synthetases class I (I, L, M and V) Aminotran_5 PF00266.19 ELR18885.1 - 1.2e-19 70.6 0.0 4.4e-14 52.2 0.0 3.1 3 0 0 3 3 3 3 Aminotransferase class-V Cys_Met_Meta_PP PF01053.20 ELR18885.1 - 0.0037 15.8 0.1 0.15 10.6 0.1 2.3 1 1 1 2 2 2 2 Cys/Met metabolism PLP-dependent enzyme DUF4407 PF14362.6 ELR18889.1 - 0.074 12.4 6.4 0.11 11.8 6.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) OSCP PF00213.18 ELR18889.1 - 0.2 11.8 4.6 0.46 10.6 0.6 2.4 2 0 0 2 2 2 0 ATP synthase delta (OSCP) subunit Spectrin PF00435.21 ELR18889.1 - 0.85 10.1 7.8 4 8.0 4.5 2.4 1 1 1 2 2 2 0 Spectrin repeat FliE PF02049.18 ELR18889.1 - 1.8 8.8 6.3 2.2 8.5 0.4 2.9 3 0 0 3 3 3 0 Flagellar hook-basal body complex protein FliE CCDC-167 PF15188.6 ELR18889.1 - 4.5 7.7 8.9 12 6.4 7.0 2.4 1 1 1 2 2 2 0 Coiled-coil domain-containing protein 167 ADIP PF11559.8 ELR18889.1 - 8.7 6.4 13.4 7.6 6.6 4.9 2.3 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding SNF2_N PF00176.23 ELR18890.1 - 9.4e-22 77.2 0.3 3e-21 75.5 0.3 1.9 1 1 0 1 1 1 1 SNF2 family N-terminal domain F-box-like PF12937.7 ELR18890.1 - 0.082 12.8 0.0 0.21 11.5 0.0 1.7 1 0 0 1 1 1 0 F-box-like NTPase_I-T PF01931.18 ELR18891.1 - 1.7e-13 50.7 0.1 2.5e-13 50.2 0.1 1.3 1 1 0 1 1 1 1 Protein of unknown function DUF84 UCR_14kD PF02271.16 ELR18892.1 - 1.2e-26 92.6 0.0 1.4e-26 92.3 0.0 1.1 1 0 0 1 1 1 1 Ubiquinol-cytochrome C reductase complex 14kD subunit RhoGAP PF00620.27 ELR18893.1 - 1e-23 83.9 0.0 2.2e-23 82.8 0.0 1.5 1 0 0 1 1 1 1 RhoGAP domain SH3_2 PF07653.17 ELR18893.1 - 7.7e-09 35.1 0.1 1.4e-08 34.3 0.1 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.6 ELR18893.1 - 0.0076 16.1 0.0 0.014 15.2 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain Peptidase_S49_N PF08496.10 ELR18893.1 - 0.77 9.8 5.5 2.1 8.4 5.5 1.7 1 0 0 1 1 1 0 Peptidase family S49 N-terminal FAM176 PF14851.6 ELR18893.1 - 1.2 8.7 4.5 2.6 7.7 4.5 1.4 1 0 0 1 1 1 0 FAM176 family Nucleo_P87 PF07267.11 ELR18893.1 - 2.2 7.0 10.8 3.7 6.3 10.8 1.3 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 SRP-alpha_N PF04086.13 ELR18893.1 - 4.6 7.1 11.8 0.7 9.8 7.8 1.7 2 0 0 2 2 2 0 Signal recognition particle, alpha subunit, N-terminal Abhydrolase_1 PF00561.20 ELR18894.1 - 9.9e-23 81.1 0.0 1.2e-22 80.8 0.0 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold Esterase PF00756.20 ELR18894.1 - 0.0012 18.5 0.0 0.0021 17.8 0.0 1.3 1 0 0 1 1 1 1 Putative esterase Hydrolase_4 PF12146.8 ELR18894.1 - 0.007 15.7 0.0 0.017 14.4 0.0 1.6 2 0 0 2 2 2 1 Serine aminopeptidase, S33 BAAT_C PF08840.11 ELR18894.1 - 0.091 12.7 0.0 0.41 10.5 0.0 1.9 2 0 0 2 2 2 0 BAAT / Acyl-CoA thioester hydrolase C terminal DUF4407 PF14362.6 ELR18895.1 - 0.0078 15.6 0.5 0.0078 15.6 0.5 1.4 2 0 0 2 2 2 1 Domain of unknown function (DUF4407) DUF4632 PF15451.6 ELR18895.1 - 0.43 10.7 4.5 1.3 9.1 4.5 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4632) FSA_C PF10479.9 ELR18895.1 - 3.1 5.8 5.8 4.4 5.3 5.8 1.1 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus BOP1NT PF08145.12 ELR18897.1 - 4.2e-50 171.1 1.9 5.3e-50 170.8 1.9 1.1 1 0 0 1 1 1 1 BOP1NT (NUC169) domain Methyltransf_25 PF13649.6 ELR18898.1 - 5.4e-12 46.3 0.1 6.5e-12 46.0 0.1 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ELR18898.1 - 3.3e-11 43.7 0.0 4.1e-11 43.4 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ELR18898.1 - 1.3e-07 31.6 0.0 1.5e-07 31.3 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 ELR18898.1 - 1.7e-06 28.0 0.0 1.7e-06 28.0 0.0 1.0 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ELR18898.1 - 4.9e-06 27.2 0.1 5.6e-06 27.0 0.1 1.2 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 ELR18898.1 - 0.0019 17.6 0.0 0.0024 17.3 0.0 1.1 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family MetW PF07021.12 ELR18898.1 - 0.0085 15.7 0.0 0.0093 15.6 0.0 1.0 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW Methyltransf_32 PF13679.6 ELR18898.1 - 0.028 14.4 0.0 0.028 14.4 0.0 1.1 1 0 0 1 1 1 0 Methyltransferase domain PCMT PF01135.19 ELR18898.1 - 0.029 14.1 0.0 0.03 14.1 0.0 1.1 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) N6_N4_Mtase PF01555.18 ELR18898.1 - 0.037 13.7 0.0 0.041 13.6 0.0 1.1 1 0 0 1 1 1 0 DNA methylase PrmA PF06325.13 ELR18898.1 - 0.081 12.3 0.0 0.091 12.1 0.0 1.1 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) AdoMet_MTase PF07757.13 ELR18898.1 - 0.09 13.1 0.0 0.12 12.7 0.0 1.2 1 0 0 1 1 1 0 Predicted AdoMet-dependent methyltransferase Methyltransf_9 PF08003.11 ELR18898.1 - 0.12 11.2 0.0 0.12 11.2 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1698) CMAS PF02353.20 ELR18898.1 - 0.13 11.6 0.0 0.15 11.4 0.0 1.1 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase TPMT PF05724.11 ELR18898.1 - 0.16 11.6 0.0 0.17 11.5 0.0 1.1 1 0 0 1 1 1 0 Thiopurine S-methyltransferase (TPMT) MTS PF05175.14 ELR18898.1 - 0.19 11.3 0.0 0.2 11.2 0.0 1.1 1 0 0 1 1 1 0 Methyltransferase small domain CsbD PF05532.12 ELR18899.1 - 1.8e-20 72.6 22.0 1.2e-13 50.8 9.1 2.0 1 1 1 2 2 2 2 CsbD-like PsiF_repeat PF07769.14 ELR18899.1 - 0.07 13.0 1.3 0.21 11.5 1.3 1.8 1 0 0 1 1 1 0 psiF repeat DUF1664 PF07889.12 ELR18900.1 - 0.03 14.4 3.1 2.5 8.2 1.2 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) DUF4502 PF14950.6 ELR18900.1 - 1.8 7.9 25.9 2.4 7.5 15.9 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4502) GTP_EFTU PF00009.27 ELR18901.1 - 2.6e-25 89.1 0.0 3.3e-25 88.8 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain F-box-like PF12937.7 ELR18901.1 - 3.3e-10 39.7 0.7 9.9e-10 38.2 0.7 1.9 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ELR18901.1 - 1.5e-06 27.9 1.2 5.1e-06 26.2 0.4 2.2 2 0 0 2 2 2 1 F-box domain MMR_HSR1 PF01926.23 ELR18901.1 - 7.2e-05 22.8 0.1 0.00095 19.2 0.0 2.6 2 1 0 2 2 2 1 50S ribosome-binding GTPase Spore_III_AB PF09548.10 ELR18901.1 - 0.003 17.7 0.0 2.4 8.2 0.0 2.9 3 0 0 3 3 3 2 Stage III sporulation protein AB (spore_III_AB) F-box_5 PF18511.1 ELR18901.1 - 0.0067 16.0 0.1 0.021 14.4 0.1 1.9 1 0 0 1 1 1 1 F-box Ad_Cy_reg PF16701.5 ELR18901.1 - 0.034 13.9 2.3 5.4 6.7 0.2 2.2 2 0 0 2 2 2 0 Adenylate cyclase regulatory domain DUF4404 PF14357.6 ELR18901.1 - 0.061 14.0 0.0 12 6.6 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4404) Transglut_core PF01841.19 ELR18901.1 - 0.2 12.1 4.3 11 6.5 0.1 3.0 3 0 0 3 3 3 0 Transglutaminase-like superfamily SOR_SNZ PF01680.17 ELR18902.1 - 9.3e-101 335.9 5.5 1.4e-100 335.3 5.5 1.3 1 0 0 1 1 1 1 SOR/SNZ family ThiG PF05690.14 ELR18902.1 - 1.2e-10 41.1 6.0 1.3e-06 27.9 0.4 2.4 2 0 0 2 2 2 2 Thiazole biosynthesis protein ThiG Dus PF01207.17 ELR18902.1 - 0.00035 19.8 1.5 0.3 10.2 0.1 2.8 2 2 0 2 2 2 2 Dihydrouridine synthase (Dus) TetR_C_27 PF17935.1 ELR18902.1 - 0.0025 17.8 0.0 0.0059 16.7 0.0 1.6 1 0 0 1 1 1 1 Tetracyclin repressor-like, C-terminal domain IGPS PF00218.21 ELR18902.1 - 0.012 14.9 0.0 0.58 9.3 0.0 2.3 2 0 0 2 2 2 0 Indole-3-glycerol phosphate synthase His_biosynth PF00977.21 ELR18902.1 - 0.013 15.0 1.1 0.18 11.2 0.1 2.5 2 1 1 3 3 3 0 Histidine biosynthesis protein NMO PF03060.15 ELR18902.1 - 0.014 14.8 9.0 0.41 10.0 0.6 2.2 2 0 0 2 2 2 0 Nitronate monooxygenase NanE PF04131.14 ELR18902.1 - 0.015 14.5 0.8 0.23 10.6 0.1 2.4 2 0 0 2 2 2 0 Putative N-acetylmannosamine-6-phosphate epimerase OMPdecase PF00215.24 ELR18902.1 - 0.033 13.8 0.1 2 8.0 0.0 2.3 1 1 1 2 2 2 0 Orotidine 5'-phosphate decarboxylase / HUMPS family Milton PF12448.8 ELR18902.1 - 0.043 13.9 0.0 0.076 13.1 0.0 1.4 1 0 0 1 1 1 0 Kinesin associated protein SNO PF01174.19 ELR18903.1 - 3.1e-53 180.4 0.0 3.6e-53 180.2 0.0 1.0 1 0 0 1 1 1 1 SNO glutamine amidotransferase family GATase_3 PF07685.14 ELR18903.1 - 1.4e-08 34.6 0.0 3.1e-08 33.4 0.0 1.5 2 0 0 2 2 2 1 CobB/CobQ-like glutamine amidotransferase domain Peptidase_S51 PF03575.17 ELR18903.1 - 0.022 14.4 0.1 0.031 13.9 0.1 1.2 1 0 0 1 1 1 0 Peptidase family S51 DJ-1_PfpI PF01965.24 ELR18903.1 - 0.11 12.3 0.0 0.15 11.8 0.0 1.3 1 0 0 1 1 1 0 DJ-1/PfpI family adh_short_C2 PF13561.6 ELR18904.1 - 2.9e-43 148.1 0.8 5.8e-40 137.3 0.8 2.9 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 ELR18904.1 - 2.4e-32 112.0 0.0 3.3e-31 108.3 0.0 2.0 1 1 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 ELR18904.1 - 7.5e-06 26.0 0.0 1e-05 25.5 0.0 1.2 1 0 0 1 1 1 1 KR domain MJ1316 PF04457.12 ELR18904.1 - 0.12 13.2 0.1 0.26 12.0 0.1 1.6 2 0 0 2 2 2 0 MJ1316 RNA cyclic group end recognition domain MIP PF00230.20 ELR18905.1 - 9.2e-27 94.2 11.7 6.7e-15 55.4 3.5 2.2 1 1 1 2 2 2 2 Major intrinsic protein TPR_2 PF07719.17 ELR18906.1 - 2.2e-09 36.7 7.0 0.0018 18.2 0.0 3.8 4 0 0 4 4 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 ELR18906.1 - 1.3e-08 34.3 5.5 0.0046 16.7 0.0 3.9 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_11 PF13414.6 ELR18906.1 - 4.1e-06 26.4 1.3 0.022 14.4 0.1 3.5 2 1 1 3 3 3 2 TPR repeat TPR_8 PF13181.6 ELR18906.1 - 0.00025 21.0 0.8 0.65 10.3 0.0 3.6 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_9 PF13371.6 ELR18906.1 - 0.00075 19.6 2.1 0.0017 18.4 0.2 2.2 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_7 PF13176.6 ELR18906.1 - 0.0011 18.8 0.8 0.33 11.1 0.0 2.7 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.6 ELR18906.1 - 0.0029 17.8 7.3 0.065 13.5 1.9 3.0 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_16 PF13432.6 ELR18906.1 - 0.003 18.2 10.5 0.077 13.7 1.7 3.1 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_17 PF13431.6 ELR18906.1 - 0.012 15.9 0.1 0.44 11.0 0.0 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF3856 PF12968.7 ELR18906.1 - 0.019 15.0 0.7 1.1 9.3 0.7 2.2 1 1 0 1 1 1 0 Domain of Unknown Function (DUF3856) MAS20 PF02064.15 ELR18906.1 - 0.028 14.5 3.3 0.054 13.6 0.1 2.2 2 1 0 2 2 2 0 MAS20 protein import receptor DUF2856 PF11043.8 ELR18906.1 - 0.028 14.5 0.2 0.22 11.6 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2856) TPR_19 PF14559.6 ELR18906.1 - 0.03 14.8 8.7 0.12 12.9 0.2 2.9 2 1 1 3 3 3 0 Tetratricopeptide repeat RhoGEF67_u2 PF16614.5 ELR18906.1 - 0.074 13.1 0.4 0.21 11.7 0.2 1.9 1 1 0 1 1 1 0 Unstructured region two on RhoGEF 6 and 7 DNA_pol_B_2 PF03175.13 ELR18906.1 - 0.26 10.1 0.0 0.39 9.5 0.0 1.2 1 0 0 1 1 1 0 DNA polymerase type B, organellar and viral TPR_10 PF13374.6 ELR18906.1 - 0.31 11.0 4.5 3.6 7.6 1.0 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_14 PF13428.6 ELR18906.1 - 1.1 10.3 10.7 0.97 10.4 0.4 3.1 3 0 0 3 3 2 0 Tetratricopeptide repeat CBS PF00571.28 ELR18907.1 - 2.2e-30 104.9 2.4 7.9e-10 39.0 0.0 4.4 4 0 0 4 4 4 4 CBS domain MFS_1 PF07690.16 ELR18908.1 - 3.9e-50 170.7 40.5 2.8e-38 131.7 16.3 2.4 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 ELR18908.1 - 3.7e-07 29.4 18.1 5.9e-05 22.1 4.8 4.2 3 2 0 3 3 3 2 Sugar (and other) transporter MFS_1_like PF12832.7 ELR18908.1 - 7.7e-06 25.0 20.7 0.0045 15.9 1.1 3.6 2 2 1 4 4 4 3 MFS_1 like family LacY_symp PF01306.19 ELR18908.1 - 0.0019 17.0 14.5 0.029 13.2 1.7 3.7 4 0 0 4 4 4 3 LacY proton/sugar symporter OATP PF03137.20 ELR18908.1 - 0.0057 15.0 7.8 0.0071 14.7 0.6 2.5 2 0 0 2 2 2 2 Organic Anion Transporter Polypeptide (OATP) family LRR19-TM PF15176.6 ELR18908.1 - 0.053 13.5 0.2 0.43 10.6 0.1 2.6 1 1 1 2 2 2 0 Leucine-rich repeat family 19 TM domain DUF2784 PF10861.8 ELR18908.1 - 5.6 7.0 9.8 1.7 8.7 2.6 2.8 2 0 0 2 2 2 0 Protein of Unknown function (DUF2784) Pkinase PF00069.25 ELR18909.1 - 4.7e-52 177.0 0.0 2.9e-51 174.4 0.0 1.9 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR18909.1 - 2e-25 89.5 0.0 2.1e-24 86.2 0.0 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ELR18909.1 - 6.6e-09 35.5 0.0 9.2e-09 35.0 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 ELR18909.1 - 7.8e-07 28.7 0.0 1.3e-06 27.9 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 ELR18909.1 - 0.0076 16.2 0.1 0.079 12.9 0.1 2.1 1 1 0 2 2 2 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 ELR18909.1 - 0.016 14.2 0.0 0.03 13.3 0.0 1.4 1 1 0 1 1 1 0 Haspin like kinase domain Pkinase_Tyr PF07714.17 ELR18910.1 - 1.9e-65 220.7 0.0 2.8e-65 220.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ELR18910.1 - 2.7e-46 158.1 0.0 4.5e-46 157.4 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Kdo PF06293.14 ELR18910.1 - 1.1e-05 25.0 0.1 1.8e-05 24.2 0.1 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 ELR18910.1 - 0.00011 21.6 0.0 0.00019 20.8 0.0 1.3 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 ELR18910.1 - 0.039 13.9 0.0 0.039 13.9 0.0 2.1 2 1 0 2 2 2 0 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 ELR18910.1 - 0.1 11.3 0.0 0.1 11.3 0.0 1.9 2 0 0 2 2 2 0 Fungal protein kinase BORCS6 PF10157.9 ELR18911.1 - 6.8e-13 49.1 0.1 1.2e-12 48.3 0.1 1.3 1 1 0 1 1 1 1 BLOC-1-related complex sub-unit 6 Ribosom_S12_S23 PF00164.25 ELR18912.1 - 1.9e-49 166.0 0.3 2.5e-49 165.7 0.3 1.1 1 0 0 1 1 1 1 Ribosomal protein S12/S23 Methyltransf_15 PF09445.10 ELR18912.1 - 0.03 13.9 0.0 0.032 13.8 0.0 1.1 1 0 0 1 1 1 0 RNA cap guanine-N2 methyltransferase DUF3007 PF11460.8 ELR18913.1 - 1.3 9.3 2.6 3.3 8.0 2.6 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3007) Trp_dioxygenase PF03301.13 ELR18914.1 - 1.3e-112 376.5 2.8 1.7e-112 376.2 2.8 1.0 1 0 0 1 1 1 1 Tryptophan 2,3-dioxygenase DUF2856 PF11043.8 ELR18914.1 - 0.087 12.9 0.0 0.24 11.5 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2856) SAPS PF04499.15 ELR18915.1 - 5.8e-36 124.3 20.8 1.6e-15 56.9 0.9 5.1 2 1 1 4 4 4 3 SIT4 phosphatase-associated protein Rcd1 PF04078.13 ELR18915.1 - 0.00027 20.3 0.0 1.1 8.5 0.0 3.3 3 0 0 3 3 3 2 Cell differentiation family, Rcd1-like FYVE PF01363.21 ELR18916.1 - 1.2e-17 63.8 10.2 1.9e-17 63.1 10.2 1.3 1 0 0 1 1 1 1 FYVE zinc finger Gly-zipper_Omp PF13488.6 ELR18916.1 - 0.13 12.3 40.2 0.32 11.0 34.3 2.4 1 1 1 2 2 2 0 Glycine zipper Rick_17kDa_Anti PF05433.15 ELR18916.1 - 1.3 9.0 41.1 5.1 7.1 41.1 2.0 1 1 0 1 1 1 0 Glycine zipper 2TM domain DHHA2 PF02833.14 ELR18917.1 - 8.9e-25 87.5 0.1 2.6e-24 86.0 0.1 1.8 1 1 0 1 1 1 1 DHHA2 domain DHH PF01368.20 ELR18917.1 - 4.4e-09 36.5 0.6 7.1e-09 35.8 0.6 1.3 1 0 0 1 1 1 1 DHH family AMP-binding PF00501.28 ELR18918.1 - 4.8e-31 107.8 0.4 1e-30 106.7 0.4 1.5 1 1 0 1 1 1 1 AMP-binding enzyme Cwf_Cwc_15 PF04889.12 ELR18919.1 - 0.23 11.1 17.9 0.38 10.4 17.9 1.3 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Sec62 PF03839.16 ELR18919.1 - 1.8 8.0 4.9 3.3 7.2 4.9 1.4 1 0 0 1 1 1 0 Translocation protein Sec62 Nucleo_P87 PF07267.11 ELR18919.1 - 7.4 5.3 10.7 11 4.8 10.7 1.3 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 SRP-alpha_N PF04086.13 ELR18919.1 - 8 6.3 24.5 16 5.3 24.5 1.5 1 1 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal BAH PF01426.18 ELR18920.1 - 3.6e-17 62.3 0.3 7.3e-17 61.4 0.3 1.6 1 0 0 1 1 1 1 BAH domain JAB PF01398.21 ELR18920.1 - 3.7e-10 39.8 0.0 1.2e-09 38.2 0.0 1.8 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Prok-JAB PF14464.6 ELR18920.1 - 3.8e-07 29.9 0.1 2.5e-06 27.3 0.0 2.3 1 1 1 2 2 2 1 Prokaryotic homologs of the JAB domain DUF2052 PF09747.9 ELR18920.1 - 1.1 9.3 30.1 1.9 8.6 9.4 3.7 3 0 0 3 3 3 0 Coiled-coil domain containing protein (DUF2052) Pkinase PF00069.25 ELR18921.1 - 1.4e-76 257.4 0.0 1.7e-76 257.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR18921.1 - 2.2e-39 135.3 0.0 3e-39 134.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ELR18921.1 - 3.5e-09 36.4 0.1 1.3e-08 34.5 0.0 1.8 2 0 0 2 2 2 1 Kinase-like Pkinase_C PF00433.24 ELR18921.1 - 3.4e-08 34.1 0.5 3.4e-08 34.1 0.5 2.4 2 0 0 2 2 1 1 Protein kinase C terminal domain Pkinase_fungal PF17667.1 ELR18921.1 - 3.1e-07 29.5 0.1 1.4e-06 27.4 0.0 1.8 2 0 0 2 2 2 1 Fungal protein kinase APH PF01636.23 ELR18921.1 - 0.00076 19.5 0.2 0.0025 17.8 0.1 1.8 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.14 ELR18921.1 - 0.0012 18.2 0.0 0.0019 17.6 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family FTA2 PF13095.6 ELR18921.1 - 0.0026 17.4 0.1 0.63 9.6 0.0 2.2 2 0 0 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 Haspin_kinase PF12330.8 ELR18921.1 - 0.0077 15.2 0.1 0.016 14.1 0.1 1.6 1 1 0 1 1 1 1 Haspin like kinase domain RIO1 PF01163.22 ELR18921.1 - 0.011 15.3 0.7 0.019 14.6 0.0 1.6 2 0 0 2 2 2 0 RIO1 family SR-25 PF10500.9 ELR18921.1 - 5.1 6.7 11.3 0.2 11.3 5.2 1.8 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein RAP1 PF07218.11 ELR18921.1 - 10 4.3 8.0 15 3.7 8.0 1.2 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) vATP-synt_AC39 PF01992.16 ELR18922.1 - 2.3e-90 303.5 3.3 4.6e-60 203.9 2.5 2.0 1 1 1 2 2 2 2 ATP synthase (C/AC39) subunit Porin_OmpL1 PF11389.8 ELR18922.1 - 0.11 11.7 0.0 0.15 11.3 0.0 1.1 1 0 0 1 1 1 0 Leptospira porin protein OmpL1 M20_dimer PF07687.14 ELR18923.1 - 2.8e-18 65.8 0.0 6e-18 64.8 0.0 1.5 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M20 PF01546.28 ELR18923.1 - 1.6e-17 63.9 0.1 4.4e-17 62.5 0.1 1.7 1 1 0 1 1 1 1 Peptidase family M20/M25/M40 Peptidase_M28 PF04389.17 ELR18923.1 - 1.8e-06 27.8 0.0 2.6e-06 27.3 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M28 zf-CHY PF05495.12 ELR18924.1 - 3.3e-12 46.7 14.2 3.3e-12 46.7 14.2 3.4 3 0 0 3 3 3 1 CHY zinc finger RWD PF05773.22 ELR18924.1 - 0.0001 22.6 0.0 0.00019 21.7 0.0 1.4 1 0 0 1 1 1 1 RWD domain Pox_Ag35 PF03286.14 ELR18924.1 - 0.025 14.4 2.8 0.047 13.5 2.8 1.4 1 0 0 1 1 1 0 Pox virus Ag35 surface protein RXT2_N PF08595.11 ELR18924.1 - 0.08 13.0 2.2 0.13 12.3 2.2 1.2 1 0 0 1 1 1 0 RXT2-like, N-terminal PBP1_TM PF14812.6 ELR18924.1 - 0.38 11.1 9.3 1.1 9.7 9.3 1.7 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DUF4746 PF15928.5 ELR18924.1 - 0.66 9.3 2.8 1 8.7 2.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Nucleo_P87 PF07267.11 ELR18924.1 - 1 8.1 2.2 1.4 7.7 2.2 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 DUF3245 PF11595.8 ELR18924.1 - 1.3 9.5 7.4 2.5 8.5 7.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3245) CDC45 PF02724.14 ELR18924.1 - 2.1 6.6 4.7 3.1 6.0 4.7 1.1 1 0 0 1 1 1 0 CDC45-like protein CENP-B_dimeris PF09026.10 ELR18924.1 - 6.4 7.2 11.9 13 6.2 11.9 1.4 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Vinculin PF01044.19 ELR18925.1 - 4.8e-23 81.4 13.8 4.8e-23 81.4 13.8 9.4 3 1 6 9 9 9 3 Vinculin family DUF4363 PF14276.6 ELR18925.1 - 0.0012 19.0 23.6 3.4 7.8 0.2 9.2 9 0 0 9 9 9 2 Domain of unknown function (DUF4363) F_actin_bind PF08919.10 ELR18925.1 - 0.0055 16.8 29.1 1.1 9.3 0.1 9.4 8 1 2 10 10 10 3 F-actin binding NIR_SIR_ferr PF03460.17 ELR18925.1 - 0.021 14.6 0.2 0.31 10.9 0.2 3.2 1 0 0 1 1 1 0 Nitrite/Sulfite reductase ferredoxin-like half domain DUF4726 PF15855.5 ELR18925.1 - 0.048 13.9 4.8 3.2 8.0 0.1 5.0 3 1 1 4 4 4 0 Domain of unknown function (DUF4726) ComP_DUS PF16732.5 ELR18925.1 - 0.37 11.7 1.7 1.9 9.4 1.7 2.3 1 0 0 1 1 1 0 Type IV minor pilin ComP, DNA uptake sequence receptor DUF1657 PF07870.11 ELR18925.1 - 4.1 7.4 27.8 2.9 7.8 0.1 7.8 8 1 0 8 8 8 0 Protein of unknown function (DUF1657) Med22 PF06179.12 ELR18926.1 - 1.4e-18 67.1 1.6 2.1e-18 66.4 1.6 1.2 1 0 0 1 1 1 1 Surfeit locus protein 5 subunit 22 of Mediator complex Methyltransf_33 PF10017.9 ELR18926.1 - 0.025 13.7 0.2 0.12 11.5 0.1 1.8 1 1 1 2 2 2 0 Histidine-specific methyltransferase, SAM-dependent Arteri_nsp7a PF16749.5 ELR18926.1 - 0.029 14.5 0.3 0.044 14.0 0.3 1.3 1 0 0 1 1 1 0 Arterivirus nonstructural protein 7 alpha DUF4407 PF14362.6 ELR18926.1 - 0.19 11.0 3.4 0.25 10.6 3.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DcrB PF08786.11 ELR18927.1 - 4.2e-10 39.8 0.0 9.9e-06 25.7 0.0 2.7 3 0 0 3 3 3 2 DcrB PsbP PF01789.16 ELR18927.1 - 1.9e-09 37.8 0.1 0.0061 16.7 0.0 4.9 4 1 0 4 4 4 3 PsbP DUF642 PF04862.12 ELR18927.1 - 0.077 12.8 0.2 10 5.9 0.0 3.3 4 0 0 4 4 4 0 Protein of unknown function (DUF642) Collagen_bind PF05737.12 ELR18927.1 - 0.18 12.0 1.0 2.4 8.3 0.1 2.7 3 0 0 3 3 3 0 Collagen binding domain TPP1 PF10341.9 ELR18928.1 - 2.7e-06 27.3 0.0 3.8e-06 26.9 0.0 1.1 1 0 0 1 1 1 1 Shelterin complex subunit, TPP1/ACD Vps23_core PF09454.10 ELR18928.1 - 0.13 12.2 0.0 0.18 11.8 0.0 1.2 1 0 0 1 1 1 0 Vps23 core domain Carb_anhydrase PF00194.21 ELR18928.1 - 0.14 11.6 0.0 0.15 11.5 0.0 1.0 1 0 0 1 1 1 0 Eukaryotic-type carbonic anhydrase zf-RanBP PF00641.18 ELR18930.1 - 2.1e-24 84.5 39.2 1.1e-06 27.9 3.8 4.1 4 0 0 4 4 4 4 Zn-finger in Ran binding protein and others TackOD1 PF18551.1 ELR18930.1 - 5e-08 32.8 17.9 0.014 15.1 0.4 4.2 4 0 0 4 4 4 4 Thaumarchaeal output domain 1 zf-4CXXC_R1 PF10497.9 ELR18930.1 - 4.8e-05 23.5 25.7 0.089 13.0 4.0 4.2 1 1 3 4 4 4 4 Zinc-finger domain of monoamine-oxidase A repressor R1 DZR PF12773.7 ELR18930.1 - 5.2e-05 23.2 30.9 0.014 15.4 11.6 3.1 2 1 0 2 2 2 2 Double zinc ribbon Auto_anti-p27 PF06677.12 ELR18930.1 - 0.046 13.9 23.9 0.56 10.4 0.9 5.9 6 0 0 6 6 6 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) Rubredoxin PF00301.20 ELR18930.1 - 0.069 13.2 32.1 0.39 10.8 0.3 5.4 7 0 0 7 7 6 0 Rubredoxin PHD PF00628.29 ELR18930.1 - 0.089 12.7 29.2 2.9 7.9 0.0 5.7 5 3 0 5 5 5 0 PHD-finger PHD_4 PF16866.5 ELR18930.1 - 0.31 11.2 20.3 2.2 8.4 0.4 4.8 5 0 0 5 5 5 0 PHD-finger HypA PF01155.19 ELR18930.1 - 0.7 9.9 22.9 1.2 9.1 0.5 4.2 2 2 2 4 4 4 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA NADH_4Fe-4S PF10589.9 ELR18930.1 - 0.82 9.8 16.1 6.3 7.0 0.6 4.4 5 0 0 5 5 5 0 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region zinc-ribbon_6 PF10005.9 ELR18930.1 - 3.8 8.3 23.5 7.5 7.3 1.0 4.7 5 0 0 5 5 5 0 zinc-ribbon domain Prim_Zn_Ribbon PF08273.12 ELR18930.1 - 4.5 7.6 29.8 1.3 9.3 0.2 6.3 5 2 2 7 7 7 0 Zinc-binding domain of primase-helicase zinc_ribbon_10 PF10058.9 ELR18930.1 - 7.4 6.4 26.7 0.55 10.0 0.7 5.0 6 1 0 6 6 6 0 Predicted integral membrane zinc-ribbon metal-binding protein RecR PF02132.15 ELR18930.1 - 8.1 6.1 27.3 1.8 8.2 1.6 4.7 4 0 0 4 4 4 0 RecR protein Fucokinase PF07959.12 ELR18931.1 - 9.9e-47 159.8 0.0 1.3e-46 159.3 0.0 1.2 1 0 0 1 1 1 1 L-fucokinase GHMP_kinases_N PF00288.26 ELR18931.1 - 5.8e-05 23.2 4.3 0.0015 18.7 1.1 3.2 2 0 0 2 2 2 1 GHMP kinases N terminal domain PAS_4 PF08448.10 ELR18931.1 - 0.45 10.8 5.1 1.9 8.8 0.5 3.6 4 0 0 4 4 4 0 PAS fold GHMP_kinases_C PF08544.13 ELR18932.1 - 7.8e-07 29.4 0.1 1.3e-06 28.7 0.1 1.4 1 0 0 1 1 1 1 GHMP kinases C terminal adh_short_C2 PF13561.6 ELR18933.1 - 4.6e-68 229.3 2.8 5.4e-68 229.1 2.8 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 ELR18933.1 - 8.5e-48 162.4 2.8 1.1e-47 162.1 2.8 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 ELR18933.1 - 8.6e-07 29.0 2.5 1.8e-06 28.0 2.4 1.6 1 1 0 1 1 1 1 KR domain Ank_2 PF12796.7 ELR18935.1 - 3.1e-47 159.1 10.3 1.3e-15 57.7 0.1 4.4 1 1 4 5 5 5 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ELR18935.1 - 1.4e-32 111.7 11.4 2.2e-08 34.4 0.1 6.1 3 2 3 6 6 6 5 Ankyrin repeats (many copies) Ank_5 PF13857.6 ELR18935.1 - 1.9e-31 107.7 13.9 1.1e-07 32.0 0.3 6.9 3 2 5 8 8 8 7 Ankyrin repeats (many copies) Ank PF00023.30 ELR18935.1 - 4.3e-31 106.0 17.6 7.3e-06 26.2 0.0 8.1 8 0 0 8 8 8 6 Ankyrin repeat Ank_3 PF13606.6 ELR18935.1 - 3e-27 91.7 14.6 0.00011 22.3 0.0 8.1 8 1 0 8 8 8 7 Ankyrin repeat DUF3678 PF12435.8 ELR18935.1 - 0.55 9.7 3.2 16 5.0 0.3 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3678) RhoGAP PF00620.27 ELR18936.1 - 9e-40 136.0 0.0 1.6e-39 135.2 0.0 1.3 1 0 0 1 1 1 1 RhoGAP domain CRAL_TRIO_2 PF13716.6 ELR18936.1 - 1.2e-35 122.7 1.8 2e-35 122.0 1.8 1.3 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain CRAL_TRIO PF00650.20 ELR18936.1 - 9.5e-12 44.9 0.8 1.5e-11 44.3 0.8 1.2 1 0 0 1 1 1 1 CRAL/TRIO domain CorC_HlyC PF03471.17 ELR18936.1 - 0.12 12.4 0.0 0.28 11.2 0.0 1.6 1 0 0 1 1 1 0 Transporter associated domain aGPT-Pplase2 PF18724.1 ELR18936.1 - 0.16 11.7 0.1 0.24 11.1 0.1 1.2 1 0 0 1 1 1 0 Alpha-glutamyl/putrescinyl thymine pyrophosphorylase clade 2 U-box PF04564.15 ELR18937.1 - 1.6e-20 73.1 0.0 2.6e-20 72.3 0.0 1.4 1 0 0 1 1 1 1 U-box domain zf-Nse PF11789.8 ELR18937.1 - 0.0003 20.5 0.0 0.00058 19.6 0.0 1.4 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-NOSIP PF15906.5 ELR18937.1 - 0.015 15.4 0.0 0.029 14.5 0.0 1.4 1 0 0 1 1 1 0 Zinc-finger of nitric oxide synthase-interacting protein WD40 PF00400.32 ELR18938.1 - 6.2e-64 210.4 18.7 5.7e-11 42.8 0.1 9.1 9 0 0 9 9 9 9 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ELR18938.1 - 7.3e-23 80.7 1.5 1.1e-05 25.6 0.0 6.8 2 2 5 7 7 7 7 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ELR18938.1 - 9.5e-12 44.5 0.0 0.0097 14.9 0.0 5.0 3 1 1 5 5 5 3 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 ELR18938.1 - 1.5e-09 37.6 1.6 0.06 13.3 0.0 4.8 5 0 0 5 5 5 3 WD40-like Beta Propeller Repeat eIF2A PF08662.11 ELR18938.1 - 3e-07 30.5 0.0 0.092 12.6 0.0 3.8 2 2 2 4 4 4 3 Eukaryotic translation initiation factor eIF2A Proteasome_A_N PF10584.9 ELR18938.1 - 8.2e-07 28.6 0.6 0.12 12.1 0.1 4.8 5 0 0 5 5 5 2 Proteasome subunit A N-terminal signature Nbas_N PF15492.6 ELR18938.1 - 0.0023 17.3 1.4 2.9 7.1 0.0 4.2 2 2 3 5 5 5 1 Neuroblastoma-amplified sequence, N terminal PALB2_WD40 PF16756.5 ELR18938.1 - 0.0058 15.6 3.9 0.19 10.6 0.1 3.6 4 0 0 4 4 4 1 Partner and localizer of BRCA2 WD40 domain Nup160 PF11715.8 ELR18938.1 - 0.024 13.3 2.6 2.1 6.9 0.0 3.8 4 2 1 5 5 5 0 Nucleoporin Nup120/160 WD40_like PF17005.5 ELR18938.1 - 0.033 13.5 0.0 4.4 6.6 0.0 3.2 3 1 1 4 4 4 0 WD40-like domain TruB_C PF09142.11 ELR18938.1 - 0.045 13.5 1.2 18 5.2 0.1 4.0 4 0 0 4 4 4 0 tRNA Pseudouridine synthase II, C terminal DPPIV_N PF00930.21 ELR18938.1 - 0.063 12.0 0.2 32 3.1 0.0 3.5 4 0 0 4 4 4 0 Dipeptidyl peptidase IV (DPP IV) N-terminal region Frtz PF11768.8 ELR18938.1 - 0.12 10.7 0.0 1.2 7.4 0.0 2.4 2 1 1 3 3 3 0 WD repeat-containing and planar cell polarity effector protein Fritz VID27 PF08553.10 ELR18938.1 - 0.13 11.2 0.0 0.37 9.8 0.0 1.7 2 0 0 2 2 2 0 VID27 C-terminal WD40-like domain TAP42 PF04177.12 ELR18939.1 - 4.4e-31 108.2 0.1 5.4e-31 107.9 0.1 1.1 1 0 0 1 1 1 1 TAP42-like family NOT2_3_5 PF04153.18 ELR18940.1 - 5.5e-31 107.4 1.5 1.1e-30 106.4 1.5 1.5 1 0 0 1 1 1 1 NOT2 / NOT3 / NOT5 family eIF2A PF08662.11 ELR18941.1 - 1.6e-44 152.1 2.7 2.5e-39 135.2 0.0 4.2 1 1 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A RRM_1 PF00076.22 ELR18941.1 - 1.7e-10 40.6 0.0 5.3e-10 39.0 0.0 1.8 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) ANAPC4_WD40 PF12894.7 ELR18941.1 - 0.00077 19.7 0.2 8.5 6.8 0.0 4.9 5 2 2 7 7 7 1 Anaphase-promoting complex subunit 4 WD40 domain IKI3 PF04762.12 ELR18941.1 - 0.019 13.0 0.0 2.3 6.1 0.0 2.8 3 0 0 3 3 3 0 IKI3 family Lactonase PF10282.9 ELR18941.1 - 0.028 13.7 0.0 0.43 9.8 0.0 2.2 1 1 1 2 2 2 0 Lactonase, 7-bladed beta-propeller AAA_11 PF13086.6 ELR18942.1 - 3.3e-14 53.3 0.0 3.6e-14 53.2 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 ELR18942.1 - 1.3e-09 38.6 0.0 1.3e-09 38.5 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 ELR18942.1 - 2.6e-07 30.5 0.0 4.3e-07 29.9 0.0 1.4 1 0 0 1 1 1 1 AAA domain ResIII PF04851.15 ELR18942.1 - 3.5e-05 23.9 0.0 5.2e-05 23.3 0.0 1.2 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit UvrD-helicase PF00580.21 ELR18942.1 - 4.9e-05 23.0 0.0 5.9e-05 22.7 0.0 1.1 1 0 0 1 1 1 1 UvrD/REP helicase N-terminal domain DEAD PF00270.29 ELR18942.1 - 0.00061 19.6 0.0 0.00085 19.1 0.0 1.2 1 0 0 1 1 1 1 DEAD/DEAH box helicase PhoH PF02562.16 ELR18942.1 - 0.00085 18.8 0.0 0.0016 17.9 0.0 1.4 1 0 0 1 1 1 1 PhoH-like protein DUF2075 PF09848.9 ELR18942.1 - 0.0023 17.2 0.0 0.003 16.9 0.0 1.1 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) AAA_16 PF13191.6 ELR18942.1 - 0.0082 16.5 0.0 0.014 15.8 0.0 1.3 1 0 0 1 1 1 1 AAA ATPase domain AAA_5 PF07728.14 ELR18942.1 - 0.0094 15.9 0.1 0.022 14.7 0.1 1.6 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_25 PF13481.6 ELR18942.1 - 0.015 14.9 0.0 0.044 13.4 0.0 1.7 2 0 0 2 2 2 0 AAA domain AAA_22 PF13401.6 ELR18942.1 - 0.023 14.9 0.0 0.045 14.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA PF00004.29 ELR18942.1 - 0.041 14.3 0.2 0.074 13.5 0.2 1.5 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.6 ELR18942.1 - 0.1 13.1 0.0 0.25 11.9 0.0 1.6 1 1 0 1 1 1 0 AAA domain RuvB_N PF05496.12 ELR18942.1 - 0.11 12.2 0.0 0.17 11.6 0.0 1.2 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain Sigma54_activat PF00158.26 ELR18942.1 - 0.17 11.6 0.0 0.24 11.1 0.0 1.2 1 0 0 1 1 1 0 Sigma-54 interaction domain ATPase PF06745.13 ELR18942.1 - 0.22 10.8 0.0 0.32 10.3 0.0 1.3 1 0 0 1 1 1 0 KaiC HMMR_N PF15905.5 ELR18944.1 - 0.0029 17.1 2.9 0.0049 16.4 2.9 1.3 1 0 0 1 1 1 1 Hyaluronan mediated motility receptor N-terminal zf-RING_2 PF13639.6 ELR18944.1 - 0.0049 17.2 0.2 0.0049 17.2 0.2 2.3 2 0 0 2 2 2 1 Ring finger domain FPP PF05911.11 ELR18944.1 - 0.016 13.5 2.0 0.021 13.0 2.0 1.1 1 0 0 1 1 1 0 Filament-like plant protein, long coiled-coil Seryl_tRNA_N PF02403.22 ELR18944.1 - 0.025 14.8 2.3 0.071 13.3 2.3 1.7 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain Zn-ribbon_8 PF09723.10 ELR18944.1 - 0.03 14.4 4.2 0.75 10.0 0.1 2.8 2 0 0 2 2 2 0 Zinc ribbon domain YscO-like PF16789.5 ELR18944.1 - 0.034 14.2 6.7 0.065 13.3 6.7 1.4 1 0 0 1 1 1 0 YscO-like protein DUF4407 PF14362.6 ELR18944.1 - 0.087 12.2 2.0 0.073 12.4 0.2 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) zinc_ribbon_15 PF17032.5 ELR18944.1 - 0.099 13.4 1.0 1.4 9.7 0.1 2.3 2 0 0 2 2 2 0 zinc-ribbon family GldM_N PF12081.8 ELR18944.1 - 0.11 12.6 0.1 0.17 11.9 0.1 1.2 1 0 0 1 1 1 0 GldM N-terminal domain FANCL_C PF11793.8 ELR18944.1 - 0.19 11.9 1.0 0.89 9.8 0.2 2.2 2 0 0 2 2 2 0 FANCL C-terminal domain APG6_N PF17675.1 ELR18944.1 - 0.2 12.2 7.3 0.055 14.0 3.7 1.8 2 0 0 2 2 2 0 Apg6 coiled-coil region DZR PF12773.7 ELR18944.1 - 0.23 11.5 4.3 12 6.0 1.4 2.3 2 0 0 2 2 2 0 Double zinc ribbon Microtub_bind PF13931.6 ELR18944.1 - 0.24 11.8 2.8 0.15 12.4 0.9 1.6 2 0 0 2 2 1 0 Kinesin-associated microtubule-binding Metal_resist PF13801.6 ELR18944.1 - 0.34 11.1 9.7 0.078 13.2 2.4 2.5 2 1 0 2 2 2 0 Heavy-metal resistance COX14 PF14880.6 ELR18944.1 - 0.38 10.6 2.8 0.71 9.8 0.0 2.4 2 1 0 2 2 2 0 Cytochrome oxidase c assembly zinc-ribbons_6 PF07191.12 ELR18944.1 - 0.38 10.8 3.8 8.7 6.4 0.1 2.4 2 0 0 2 2 2 0 zinc-ribbons GFA PF04828.14 ELR18944.1 - 0.43 11.0 3.0 8.7 6.8 0.1 2.5 2 0 0 2 2 2 0 Glutathione-dependent formaldehyde-activating enzyme zf-TFIIB PF13453.6 ELR18944.1 - 0.47 9.8 2.3 1.6 8.1 0.1 2.7 2 0 0 2 2 2 0 Transcription factor zinc-finger zinc_ribbon_2 PF13240.6 ELR18944.1 - 0.72 9.7 3.4 4.9 7.0 0.1 2.7 2 0 0 2 2 2 0 zinc-ribbon domain DUF2203 PF09969.9 ELR18944.1 - 1.5 9.6 4.7 1.4 9.6 1.4 2.3 2 1 0 2 2 2 0 Uncharacterized conserved protein (DUF2203) Auto_anti-p27 PF06677.12 ELR18944.1 - 7.1 6.9 5.9 7.5 6.8 0.3 2.4 2 0 0 2 2 2 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) Kelch_6 PF13964.6 ELR18946.1 - 5.6e-08 32.8 2.4 2 8.8 0.0 6.8 6 1 1 7 7 7 2 Kelch motif Kelch_3 PF13415.6 ELR18946.1 - 1.3e-07 31.7 10.8 0.51 10.7 0.0 7.1 7 2 0 7 7 7 3 Galactose oxidase, central domain Kelch_4 PF13418.6 ELR18946.1 - 3.6e-07 30.1 11.1 0.017 15.1 0.2 6.3 7 0 0 7 7 7 2 Galactose oxidase, central domain Kelch_2 PF07646.15 ELR18946.1 - 9.3e-05 22.2 2.1 1.2 9.2 0.1 5.6 8 0 0 8 8 8 1 Kelch motif Kelch_1 PF01344.25 ELR18946.1 - 0.14 11.8 4.7 15 5.3 0.1 4.0 4 0 0 4 4 4 0 Kelch motif Pkinase_Tyr PF07714.17 ELR18947.1 - 7.4e-104 346.6 0.0 4.1e-51 173.8 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 ELR18947.1 - 6.4e-98 327.3 0.0 6.3e-49 166.7 0.0 2.5 3 0 0 3 3 3 2 Protein kinase domain PBP_like_2 PF12849.7 ELR18947.1 - 7.2e-41 140.7 8.9 1.1e-20 74.4 0.4 2.9 3 0 0 3 3 3 2 PBP superfamily domain Kinase-like PF14531.6 ELR18947.1 - 1.4e-09 37.7 0.0 0.0001 21.7 0.0 2.3 2 0 0 2 2 2 2 Kinase-like APH PF01636.23 ELR18947.1 - 1.5e-05 25.1 0.1 0.0077 16.2 0.0 2.6 2 0 0 2 2 2 2 Phosphotransferase enzyme family FTA2 PF13095.6 ELR18947.1 - 9.9e-05 22.1 0.0 0.052 13.2 0.0 3.3 2 1 1 3 3 3 1 Kinetochore Sim4 complex subunit FTA2 Pkinase_fungal PF17667.1 ELR18947.1 - 0.00026 19.9 0.0 0.16 10.7 0.0 2.2 2 0 0 2 2 2 2 Fungal protein kinase Kdo PF06293.14 ELR18947.1 - 0.00049 19.5 0.0 0.79 9.0 0.0 2.3 2 0 0 2 2 2 2 Lipopolysaccharide kinase (Kdo/WaaP) family TMEM154 PF15102.6 ELR18947.1 - 0.00064 19.6 0.0 0.002 18.0 0.0 1.8 1 0 0 1 1 1 1 TMEM154 protein family ABC1 PF03109.16 ELR18947.1 - 0.025 14.7 0.0 0.067 13.4 0.0 1.6 1 0 0 1 1 1 0 ABC1 family CENP-B_dimeris PF09026.10 ELR18947.1 - 0.035 14.5 3.8 0.092 13.1 3.8 1.6 1 0 0 1 1 1 0 Centromere protein B dimerisation domain EphA2_TM PF14575.6 ELR18947.1 - 0.12 13.3 0.0 0.34 11.8 0.0 1.7 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain RIO1 PF01163.22 ELR18947.1 - 0.12 11.9 0.2 8.4 5.9 0.3 2.6 2 1 0 2 2 2 0 RIO1 family FSAP_sig_propep PF03032.15 ELR18947.1 - 0.67 10.0 0.0 0.67 10.0 0.0 2.6 3 0 0 3 3 1 0 Frog skin active peptide family signal and propeptide DUF2457 PF10446.9 ELR18947.1 - 0.73 8.9 3.4 1.1 8.3 3.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) EGF_2 PF07974.13 ELR18947.1 - 3.3 8.2 16.9 0.36 11.2 11.1 2.5 2 0 0 2 2 2 0 EGF-like domain EGF PF00008.27 ELR18947.1 - 5.8 7.3 10.1 1.8 8.9 6.6 2.1 2 0 0 2 2 1 0 EGF-like domain Peptidase_C97 PF05903.14 ELR18948.1 - 2.6e-05 24.1 0.0 4.3e-05 23.4 0.0 1.5 1 0 0 1 1 1 1 PPPDE putative peptidase domain ApoL PF05461.11 ELR18948.1 - 0.0043 16.4 0.2 0.0058 16.0 0.2 1.2 1 0 0 1 1 1 1 Apolipoprotein L DUF3381 PF11861.8 ELR18951.1 - 0.1 12.4 3.3 0.51 10.1 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF3381) TP6A_N PF04406.14 ELR18952.1 - 0.00041 20.3 1.7 0.0018 18.2 0.0 2.5 2 1 1 3 3 3 1 Type IIB DNA topoisomerase Bravo_FIGEY PF13882.6 ELR18952.1 - 1.8 10.0 6.2 4.5 8.7 6.2 1.6 1 0 0 1 1 1 0 Bravo-like intracellular region FAM176 PF14851.6 ELR18954.1 - 2 8.1 6.1 11 5.6 0.3 2.7 2 0 0 2 2 2 0 FAM176 family Vwaint PF14624.6 ELR18955.1 - 4.9e-26 90.7 0.1 9.7e-26 89.7 0.1 1.5 1 0 0 1 1 1 1 VWA / Hh protein intein-like Vint PF14623.6 ELR18955.1 - 1.6e-21 76.8 0.0 2.1e-20 73.2 0.0 2.3 2 0 0 2 2 2 1 Hint-domain U-box PF04564.15 ELR18955.1 - 1.2e-17 63.8 0.0 2.6e-17 62.7 0.0 1.5 1 0 0 1 1 1 1 U-box domain VWA PF00092.28 ELR18955.1 - 5.1e-15 56.1 0.0 1.2e-14 54.9 0.0 1.6 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.6 ELR18955.1 - 2.9e-12 47.2 0.0 7e-12 45.9 0.0 1.7 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_3 PF13768.6 ELR18955.1 - 3.5e-08 33.5 0.0 7.8e-08 32.4 0.0 1.6 1 1 0 1 1 1 1 von Willebrand factor type A domain zf-Nse PF11789.8 ELR18955.1 - 0.0094 15.7 0.0 0.019 14.8 0.0 1.4 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit Hint PF01079.20 ELR18955.1 - 0.1 12.1 0.1 0.1 12.1 0.1 1.6 2 0 0 2 2 2 0 Hint module DUF43 PF01861.16 ELR18955.1 - 0.11 11.7 0.0 0.19 11.0 0.0 1.2 1 0 0 1 1 1 0 Branched-chain polyamine synthase A C-terminal domain Hydrolase PF00702.26 ELR18957.1 - 0.0056 17.0 0.0 0.0084 16.4 0.0 1.3 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase DUF4476 PF14771.6 ELR18958.1 - 1.4e-06 28.5 0.0 0.00015 22.0 0.0 2.3 1 1 1 2 2 2 2 Domain of unknown function (DUF4476) fn3_PAP PF17808.1 ELR18960.1 - 5.3e-23 81.4 1.8 4.4e-22 78.4 1.8 2.4 1 1 0 1 1 1 1 Fn3-like domain from Purple Acid Phosphatase Metallophos PF00149.28 ELR18960.1 - 1.7e-18 67.9 0.9 3.2e-18 67.0 0.9 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Pur_ac_phosph_N PF16656.5 ELR18960.1 - 5.8e-18 65.2 2.3 1.5e-17 64.0 0.2 2.3 2 0 0 2 2 2 1 Purple acid Phosphatase, N-terminal domain Metallophos_C PF14008.6 ELR18960.1 - 1.1e-09 39.0 0.4 7.6e-09 36.3 0.0 2.7 3 0 0 3 3 3 1 Iron/zinc purple acid phosphatase-like protein C Metallophos_2 PF12850.7 ELR18960.1 - 0.021 15.0 0.0 0.094 12.9 0.0 1.9 1 1 0 1 1 1 0 Calcineurin-like phosphoesterase superfamily domain WD40 PF00400.32 ELR18961.1 - 5e-07 30.3 0.1 0.026 15.4 0.0 2.5 1 1 1 2 2 2 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ELR18961.1 - 0.00017 21.8 0.0 0.4 11.0 0.0 2.5 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ELR18961.1 - 0.0037 16.3 0.8 0.27 10.1 0.1 2.1 1 1 1 2 2 2 2 WD40 region of Ge1, enhancer of mRNA-decapping protein fn3_PAP PF17808.1 ELR18962.1 - 1.8e-28 99.0 1.9 1.5e-27 96.0 1.9 2.3 1 1 0 1 1 1 1 Fn3-like domain from Purple Acid Phosphatase Metallophos PF00149.28 ELR18962.1 - 6.4e-19 69.3 2.4 3.8e-18 66.8 2.0 2.0 1 1 1 2 2 2 1 Calcineurin-like phosphoesterase Pur_ac_phosph_N PF16656.5 ELR18962.1 - 1e-18 67.7 0.2 6.3e-18 65.1 0.0 2.2 2 0 0 2 2 2 1 Purple acid Phosphatase, N-terminal domain Metallophos_C PF14008.6 ELR18962.1 - 8.3e-13 49.0 0.1 4.4e-11 43.5 0.0 2.7 2 0 0 2 2 2 1 Iron/zinc purple acid phosphatase-like protein C HECW_N PF16562.5 ELR18962.1 - 0.032 14.0 0.0 0.077 12.8 0.0 1.6 1 0 0 1 1 1 0 N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2 DNMT1-RFD PF12047.8 ELR18963.1 - 0.024 14.7 0.0 0.024 14.7 0.0 1.0 1 0 0 1 1 1 0 Cytosine specific DNA methyltransferase replication foci domain FRG1 PF06229.12 ELR18965.1 - 7.2e-16 58.5 0.1 6.6e-06 26.0 0.0 2.9 1 1 2 3 3 3 3 FRG1-like domain Fascin PF06268.13 ELR18965.1 - 5.6e-15 55.5 0.1 1.2e-12 48.0 0.1 2.1 1 1 1 2 2 2 2 Fascin domain RicinB_lectin_2 PF14200.6 ELR18965.1 - 3.6e-06 27.6 0.3 0.0018 19.0 0.0 1.7 1 1 1 2 2 2 2 Ricin-type beta-trefoil lectin domain-like DUF569 PF04601.13 ELR18965.1 - 2e-05 24.3 0.0 0.00033 20.4 0.0 2.0 1 1 1 2 2 2 1 Domain of unknown function (DUF569) FGF PF00167.18 ELR18965.1 - 2e-05 24.7 0.0 0.00012 22.2 0.0 1.8 1 1 1 2 2 2 1 Fibroblast growth factor IL8 PF00048.20 ELR18965.1 - 0.071 13.3 0.0 3.5 7.8 0.0 2.3 2 0 0 2 2 2 0 Small cytokines (intecrine/chemokine), interleukin-8 like Inhibitor_I67 PF11405.8 ELR18965.1 - 0.12 12.7 0.7 15 5.9 0.0 2.7 3 0 0 3 3 3 0 Bromelain inhibitor VI DnaJ_CXXCXGXG PF00684.19 ELR18967.1 - 0.98 9.8 22.2 0.076 13.4 15.3 2.4 1 1 1 2 2 2 0 DnaJ central domain SPRY PF00622.28 ELR18968.1 - 1.5e-15 57.4 0.6 4.6e-15 55.8 0.6 1.9 1 1 0 1 1 1 1 SPRY domain F-box-like PF12937.7 ELR18968.1 - 9.2e-08 31.9 1.4 1.8e-07 30.9 1.4 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ELR18968.1 - 0.0077 16.1 1.6 0.012 15.4 1.6 1.4 1 0 0 1 1 1 1 F-box domain EAP30 PF04157.16 ELR18969.1 - 2.3e-68 230.0 0.0 2.6e-68 229.8 0.0 1.0 1 0 0 1 1 1 1 EAP30/Vps36 family LBP_BPI_CETP_C PF02886.17 ELR18970.1 - 5.5e-28 98.0 0.0 8.6e-28 97.4 0.0 1.3 1 0 0 1 1 1 1 LBP / BPI / CETP family, C-terminal domain LBP_BPI_CETP PF01273.25 ELR18970.1 - 3.8e-17 62.4 1.1 3.8e-17 62.4 1.1 1.8 2 0 0 2 2 2 1 LBP / BPI / CETP family, N-terminal domain Lum_binding PF00677.17 ELR18970.1 - 0.07 13.1 0.5 2.5 8.1 0.0 3.0 3 0 0 3 3 3 0 Lumazine binding domain F-box-like PF12937.7 ELR18971.1 - 6.5e-09 35.5 1.1 1.3e-08 34.6 1.1 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ELR18971.1 - 3.4e-07 30.0 0.6 7.1e-07 28.9 0.6 1.5 1 0 0 1 1 1 1 F-box domain Elongin_A PF06881.11 ELR18971.1 - 0.037 14.6 0.0 0.052 14.1 0.0 1.2 1 0 0 1 1 1 0 RNA polymerase II transcription factor SIII (Elongin) subunit A Fz PF01392.22 ELR18972.1 - 7.5e-07 29.8 5.7 7.5e-07 29.8 5.7 1.9 2 0 0 2 2 2 1 Fz domain Folate_rec PF03024.14 ELR18972.1 - 0.034 14.0 2.1 0.059 13.2 2.1 1.3 1 0 0 1 1 1 0 Folate receptor family Promethin PF16015.5 ELR18972.1 - 0.052 13.5 0.3 0.052 13.5 0.3 3.2 3 1 0 3 3 3 0 Promethin Rhodanese PF00581.20 ELR18973.1 - 4e-17 62.7 0.0 1.7e-09 38.1 0.0 2.5 2 1 0 2 2 2 2 Rhodanese-like domain LIM PF00412.22 ELR18974.1 - 1.9e-09 37.6 4.9 6e-09 36.0 4.9 1.9 1 1 0 1 1 1 1 LIM domain DAO PF01266.24 ELR18975.1 - 2.2e-05 24.2 0.0 2.6e-05 24.0 0.0 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 ELR18975.1 - 0.0043 16.3 0.0 0.0043 16.3 0.0 1.0 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 ELR18975.1 - 0.0047 17.4 0.0 0.0057 17.2 0.0 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Mqo PF06039.15 ELR18975.1 - 0.005 15.4 0.0 0.005 15.4 0.0 1.0 1 0 0 1 1 1 1 Malate:quinone oxidoreductase (Mqo) NAD_binding_8 PF13450.6 ELR18975.1 - 0.012 15.8 0.0 0.016 15.4 0.0 1.2 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain AlaDh_PNT_C PF01262.21 ELR18975.1 - 0.024 14.0 0.3 0.026 13.8 0.3 1.1 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Thi4 PF01946.17 ELR18975.1 - 0.03 13.5 0.0 0.032 13.5 0.0 1.1 1 0 0 1 1 1 0 Thi4 family Glu_dehyd_C PF16912.5 ELR18975.1 - 0.036 13.5 0.0 0.036 13.5 0.0 1.0 1 0 0 1 1 1 0 Glucose dehydrogenase C-terminus Trp_halogenase PF04820.14 ELR18975.1 - 0.058 12.2 0.0 0.06 12.2 0.0 1.0 1 0 0 1 1 1 0 Tryptophan halogenase ApbA PF02558.16 ELR18975.1 - 0.069 12.8 0.0 0.078 12.6 0.0 1.1 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA NAD_Gly3P_dh_N PF01210.23 ELR18975.1 - 0.09 12.7 0.0 0.09 12.7 0.0 1.1 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus FAD_binding_3 PF01494.19 ELR18975.1 - 0.1 11.8 0.2 0.12 11.6 0.2 1.1 1 0 0 1 1 1 0 FAD binding domain UDPG_MGDP_dh_N PF03721.14 ELR18975.1 - 0.14 11.8 0.1 0.17 11.4 0.1 1.2 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain DAO PF01266.24 ELR18976.1 - 3.9e-21 76.0 0.0 4.4e-21 75.8 0.0 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase VWA_2 PF13519.6 ELR18977.1 - 1.5e-13 51.3 0.0 4.3e-13 49.9 0.0 1.8 1 0 0 1 1 1 1 von Willebrand factor type A domain INT_SG_DDX_CT_C PF15300.6 ELR18977.1 - 0.00019 21.2 0.3 0.00078 19.2 0.2 2.0 2 0 0 2 2 2 1 INTS6/SAGE1/DDX26B/CT45 C-terminus VWA PF00092.28 ELR18977.1 - 0.0013 19.0 0.0 0.0025 18.1 0.0 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain TFIIB PF00382.19 ELR18978.1 - 4.3e-31 106.8 4.5 5.9e-15 55.1 0.2 2.2 2 0 0 2 2 2 2 Transcription factor TFIIB repeat TF_Zn_Ribbon PF08271.12 ELR18978.1 - 3.1e-13 49.0 2.3 5.5e-13 48.2 2.3 1.4 1 0 0 1 1 1 1 TFIIB zinc-binding Cyclin_C PF02984.19 ELR18978.1 - 2.8e-05 24.2 0.1 0.017 15.2 0.0 2.2 1 1 1 2 2 2 2 Cyclin, C-terminal domain Rrf2 PF02082.20 ELR18978.1 - 5.4e-05 23.5 1.1 0.05 14.0 0.0 2.7 3 0 0 3 3 3 2 Transcriptional regulator Cyclin_N PF00134.23 ELR18978.1 - 0.00047 19.9 0.2 0.014 15.1 0.0 2.1 1 1 1 2 2 2 1 Cyclin, N-terminal domain HTH_Mga PF08280.11 ELR18978.1 - 0.0018 18.3 0.1 0.0067 16.4 0.0 2.0 2 0 0 2 2 2 1 M protein trans-acting positive regulator (MGA) HTH domain HTH_Tnp_ISL3 PF13542.6 ELR18978.1 - 0.0065 15.9 0.0 2.2 7.7 0.0 2.4 2 0 0 2 2 2 2 Helix-turn-helix domain of transposase family ISL3 GerE PF00196.19 ELR18978.1 - 0.0082 15.7 0.3 6.7 6.4 0.0 2.9 3 0 0 3 3 3 2 Bacterial regulatory proteins, luxR family HTH_11 PF08279.12 ELR18978.1 - 0.012 15.5 0.0 1.5 8.9 0.0 2.4 2 0 0 2 2 2 0 HTH domain Put_DNA-bind_N PF06971.13 ELR18978.1 - 0.034 14.1 0.2 3.6 7.7 0.0 3.1 2 1 1 3 3 3 0 Putative DNA-binding protein N-terminus HTH_5 PF01022.20 ELR18978.1 - 0.052 13.4 0.0 1.2 9.0 0.0 2.6 2 0 0 2 2 2 0 Bacterial regulatory protein, arsR family Phage_terminase PF10668.9 ELR18978.1 - 0.064 13.3 2.2 1.9 8.5 0.0 3.2 3 1 0 3 3 3 0 Phage terminase small subunit RB_B PF01857.20 ELR18978.1 - 0.088 12.8 0.1 2.3 8.3 0.2 2.1 1 1 0 2 2 2 0 Retinoblastoma-associated protein B domain Sigma70_r4_2 PF08281.12 ELR18978.1 - 0.17 11.6 0.2 2 8.1 0.1 2.5 2 0 0 2 2 2 0 Sigma-70, region 4 Bac_surface_Ag PF01103.23 ELR18979.1 - 2e-27 96.5 0.0 1.2e-14 54.6 0.0 2.7 1 1 1 2 2 2 2 Surface antigen Nitroreductase PF00881.24 ELR18980.1 - 3.9e-29 101.9 0.0 5.1e-29 101.5 0.0 1.2 1 0 0 1 1 1 1 Nitroreductase family TM1586_NiRdase PF14512.6 ELR18980.1 - 9.1e-07 28.7 0.0 0.045 13.3 0.0 3.0 2 1 1 3 3 3 3 Putative TM nitroreductase CENP-H PF05837.12 ELR18982.1 - 4.8e-09 36.6 10.8 4.8e-09 36.6 10.8 3.3 1 1 1 2 2 2 1 Centromere protein H (CENP-H) Amidinotransf PF02274.17 ELR18982.1 - 0.11 11.5 5.7 0.21 10.6 5.8 1.4 1 1 0 1 1 1 0 Amidinotransferase PPP4R2 PF09184.11 ELR18982.1 - 4.7 6.7 13.7 7.4 6.1 13.7 1.3 1 0 0 1 1 1 0 PPP4R2 Geminin PF07412.12 ELR18983.1 - 0.018 14.8 0.1 0.025 14.3 0.1 1.3 1 0 0 1 1 1 0 Geminin Cnn_1N PF07989.11 ELR18983.1 - 0.029 14.5 0.9 0.045 13.9 0.9 1.3 1 0 0 1 1 1 0 Centrosomin N-terminal motif 1 Herpes_BLRF2 PF05812.12 ELR18983.1 - 0.031 14.4 0.0 0.088 12.9 0.0 1.8 1 1 1 2 2 2 0 Herpesvirus BLRF2 protein YabA PF06156.13 ELR18983.1 - 0.057 14.1 0.1 0.065 13.9 0.1 1.2 1 0 0 1 1 1 0 Initiation control protein YabA DivIC PF04977.15 ELR18983.1 - 0.067 13.0 0.1 0.092 12.5 0.1 1.2 1 0 0 1 1 1 0 Septum formation initiator Herpes_pp85 PF04637.12 ELR18983.1 - 0.12 10.8 1.5 0.12 10.7 1.5 1.1 1 0 0 1 1 1 0 Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25) FAM184 PF15665.5 ELR18984.1 - 1.7e-05 24.7 18.0 1.7e-05 24.7 18.0 6.9 4 2 3 7 7 7 1 Family with sequence similarity 184, A and B ATG16 PF08614.11 ELR18984.1 - 0.0096 16.2 26.5 0.0096 16.2 26.5 9.0 6 2 4 10 10 10 2 Autophagy protein 16 (ATG16) Peptidase_S8 PF00082.22 ELR18985.1 - 1e-31 110.4 0.6 5.4e-24 85.0 0.1 2.3 1 1 1 2 2 2 2 Subtilase family P_proprotein PF01483.20 ELR18985.1 - 1.2e-13 50.8 0.4 2.9e-13 49.6 0.4 1.7 1 0 0 1 1 1 1 Proprotein convertase P-domain S8_pro-domain PF16470.5 ELR18985.1 - 5e-09 36.8 1.1 1.3e-08 35.5 1.1 1.7 1 0 0 1 1 1 1 Peptidase S8 pro-domain TruD PF01142.18 ELR18985.1 - 0.059 12.2 0.0 0.085 11.7 0.0 1.1 1 0 0 1 1 1 0 tRNA pseudouridine synthase D (TruD) Xpo1 PF08389.12 ELR18986.1 - 9.2e-11 42.0 0.0 4.9e-10 39.7 0.0 2.3 2 0 0 2 2 2 1 Exportin 1-like protein Yae1_N PF09811.9 ELR18986.1 - 0.024 14.3 7.0 0.053 13.2 7.0 1.5 1 0 0 1 1 1 0 Essential protein Yae1, N terminal Viral_DNA_bi PF02236.17 ELR18986.1 - 0.069 13.3 0.0 0.23 11.7 0.0 1.9 1 0 0 1 1 1 0 Viral DNA-binding protein, all alpha domain GST_C_2 PF13410.6 ELR18986.1 - 0.12 12.4 0.2 1 9.4 0.2 2.7 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain Pkinase_Tyr PF07714.17 ELR18987.1 - 2e-41 142.0 0.0 5.1e-41 140.7 0.0 1.7 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ELR18987.1 - 3.6e-27 95.4 0.0 1.3e-26 93.5 0.0 2.0 1 0 0 1 1 1 1 Protein kinase domain Arm PF00514.23 ELR18987.1 - 1e-15 57.2 13.7 0.00091 19.2 0.3 8.1 8 1 0 8 8 7 5 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.6 ELR18987.1 - 1.6e-10 41.2 23.9 0.0014 18.9 0.1 7.0 4 2 0 6 6 6 4 HEAT repeats LRR_8 PF13855.6 ELR18987.1 - 5.7e-10 38.8 14.9 5.7e-06 26.0 4.7 4.3 2 2 2 4 4 4 3 Leucine rich repeat Arm_2 PF04826.13 ELR18987.1 - 2.9e-07 30.2 1.7 0.0044 16.5 0.1 4.3 3 1 1 4 4 4 2 Armadillo-like LRR_9 PF14580.6 ELR18987.1 - 4.3e-07 29.6 11.8 1.2e-06 28.2 0.1 3.5 2 1 1 3 3 3 2 Leucine-rich repeat LRR_4 PF12799.7 ELR18987.1 - 1.9e-06 28.1 9.7 2.4e-05 24.6 0.5 3.9 1 1 2 4 4 4 2 Leucine Rich repeats (2 copies) V-ATPase_H_C PF11698.8 ELR18987.1 - 6.1e-05 23.1 13.0 1.3 9.1 0.0 6.3 7 1 1 8 8 7 3 V-ATPase subunit H HEAT PF02985.22 ELR18987.1 - 0.094 13.0 16.3 0.28 11.6 0.7 7.3 7 1 1 8 8 6 0 HEAT repeat V_ATPase_I PF01496.19 ELR18987.1 - 0.84 7.5 19.6 1.2 6.9 19.6 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Presenilin PF01080.17 ELR18987.1 - 1.5 7.5 17.8 2.8 6.6 17.8 1.4 1 0 0 1 1 1 0 Presenilin PAT1 PF09770.9 ELR18987.1 - 9.7 4.3 29.2 16 3.6 29.2 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 RhoGEF PF00621.20 ELR18988.1 - 2.4e-24 86.6 0.0 2.8e-24 86.4 0.0 1.0 1 0 0 1 1 1 1 RhoGEF domain CDC73_N PF16050.5 ELR18990.1 - 1.2e-44 152.8 0.2 2e-44 152.1 0.2 1.3 1 0 0 1 1 1 1 Paf1 complex subunit CDC73 N-terminal CDC73_C PF05179.14 ELR18990.1 - 3.9e-42 143.6 4.6 2.2e-41 141.2 1.1 3.2 2 1 0 2 2 2 1 RNA pol II accessory factor, Cdc73 family, C-terminal SIR2 PF02146.17 ELR18991.1 - 9.6e-23 81.0 0.7 3.7e-20 72.6 0.0 2.4 2 1 0 2 2 2 2 Sir2 family DUF4209 PF13910.6 ELR18992.1 - 2.2e-16 59.8 0.0 4.4e-16 58.9 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4209) Ribosomal_60s PF00428.19 ELR18992.1 - 7.4 7.2 12.4 10 6.8 3.2 4.4 4 0 0 4 4 4 0 60s Acidic ribosomal protein RRM_1 PF00076.22 ELR18993.1 - 1.2e-13 50.7 0.0 1.9e-13 50.0 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 ELR18993.1 - 0.00048 19.7 0.0 0.00096 18.7 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Calcipressin PF04847.12 ELR18993.1 - 0.004 16.9 0.0 0.004 16.9 0.0 2.1 2 0 0 2 2 2 1 Calcipressin DnaJ PF00226.31 ELR18994.1 - 4.6e-14 52.3 0.0 1.4e-13 50.7 0.0 1.8 1 0 0 1 1 1 1 DnaJ domain fn3 PF00041.21 ELR18994.1 - 4e-12 46.3 0.0 1.2e-11 44.8 0.0 1.9 1 0 0 1 1 1 1 Fibronectin type III domain Pur_ac_phosph_N PF16656.5 ELR18994.1 - 1.6e-07 31.8 0.1 3.2e-06 27.6 0.0 3.1 3 0 0 3 3 3 1 Purple acid Phosphatase, N-terminal domain RRM_1 PF00076.22 ELR18994.1 - 0.00015 21.5 0.0 0.00032 20.5 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) B2-adapt-app_C PF09066.10 ELR18995.1 - 1.9e-16 60.1 0.0 2.7e-16 59.6 0.0 1.2 1 0 0 1 1 1 1 Beta2-adaptin appendage, C-terminal sub-domain DUF3042 PF11240.8 ELR18995.1 - 0.24 11.4 0.8 0.43 10.6 0.8 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3042) USP7_ICP0_bdg PF12436.8 ELR18996.1 - 6.9e-59 199.1 0.0 1.7e-58 197.8 0.0 1.7 2 0 0 2 2 2 1 ICP0-binding domain of Ubiquitin-specific protease 7 USP7_C2 PF14533.6 ELR18996.1 - 4.2e-50 170.3 0.0 1.2e-49 168.8 0.0 1.8 2 0 0 2 2 2 1 Ubiquitin-specific protease C-terminal UCH PF00443.29 ELR18996.1 - 3.2e-47 161.2 0.1 5.8e-47 160.4 0.1 1.4 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 ELR18996.1 - 1.1e-18 67.9 0.0 5.9e-17 62.2 0.0 2.3 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase MATH PF00917.26 ELR18996.1 - 1.3e-07 31.7 0.0 5.8e-07 29.7 0.0 2.0 2 0 0 2 2 2 1 MATH domain Stealth_CR2 PF11380.8 ELR18996.1 - 0.0065 16.6 0.0 0.031 14.5 0.0 2.1 2 0 0 2 2 2 1 Stealth protein CR2, conserved region 2 RA PF00788.23 ELR18996.1 - 0.007 17.0 0.1 17 6.1 0.0 3.7 4 0 0 4 4 4 1 Ras association (RalGDS/AF-6) domain ubiquitin PF00240.23 ELR18996.1 - 0.033 13.9 0.0 0.89 9.3 0.0 2.7 2 0 0 2 2 2 0 Ubiquitin family NOA36 PF06524.12 ELR18996.1 - 2.4 7.4 11.0 3.8 6.8 11.0 1.3 1 0 0 1 1 1 0 NOA36 protein DUF2852 PF11014.8 ELR18998.1 - 0.1 12.8 0.1 0.2 11.8 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2852) SUIM_assoc PF16619.5 ELR18998.1 - 0.24 11.5 7.1 0.4 10.8 7.1 1.5 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 Androgen_recep PF02166.16 ELR18998.1 - 1.5 7.6 13.0 2 7.2 13.0 1.1 1 0 0 1 1 1 0 Androgen receptor Spt20 PF12090.8 ELR18998.1 - 2.1 7.9 8.0 2.3 7.8 8.0 1.1 1 0 0 1 1 1 0 Spt20 family PPR_2 PF13041.6 ELR18999.1 - 1.3e-19 70.1 0.0 0.057 13.6 0.0 8.7 8 1 3 11 11 11 6 PPR repeat family PPR PF01535.20 ELR18999.1 - 1.2e-16 59.7 1.7 9e-05 22.5 0.0 9.5 10 0 0 10 10 10 4 PPR repeat PPR_3 PF13812.6 ELR18999.1 - 3.1e-09 36.7 0.0 0.031 14.3 0.0 6.0 5 1 0 5 5 5 2 Pentatricopeptide repeat domain PPR_1 PF12854.7 ELR18999.1 - 1.9e-08 33.8 0.6 0.48 10.2 0.0 6.8 9 0 0 9 9 9 3 PPR repeat PPR_long PF17177.4 ELR18999.1 - 1.5e-05 24.5 0.0 0.008 15.6 0.0 3.2 4 0 0 4 4 4 2 Pentacotripeptide-repeat region of PRORP TPR_14 PF13428.6 ELR18999.1 - 1.8e-05 25.1 6.5 0.29 12.1 0.0 7.2 7 1 0 7 7 7 1 Tetratricopeptide repeat RWP-RK PF02042.15 ELR19000.1 - 3.9e-24 84.4 0.1 6.6e-24 83.6 0.1 1.4 1 0 0 1 1 1 1 RWP-RK domain HTH_6 PF01418.17 ELR19000.1 - 0.19 11.7 0.0 0.43 10.6 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain, rpiR family PH PF00169.29 ELR19001.1 - 5.6e-13 49.3 0.0 1.1e-12 48.3 0.0 1.5 1 0 0 1 1 1 1 PH domain PH_11 PF15413.6 ELR19001.1 - 4.4e-05 23.9 0.1 0.00016 22.0 0.0 2.1 2 0 0 2 2 1 1 Pleckstrin homology domain PH_3 PF14593.6 ELR19001.1 - 0.00016 21.7 0.0 0.00031 20.8 0.0 1.3 1 0 0 1 1 1 1 PH domain ATG16 PF08614.11 ELR19001.1 - 0.00069 19.9 16.0 0.00069 19.9 16.0 3.9 3 1 2 5 5 4 1 Autophagy protein 16 (ATG16) Rootletin PF15035.6 ELR19001.1 - 0.0038 17.3 9.4 0.015 15.4 1.6 2.4 2 0 0 2 2 2 1 Ciliary rootlet component, centrosome cohesion DUF3584 PF12128.8 ELR19001.1 - 0.0043 14.7 21.4 0.0063 14.1 21.4 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3584) TPR_MLP1_2 PF07926.12 ELR19001.1 - 0.0047 17.0 21.0 0.0047 17.0 21.0 2.7 2 1 1 3 3 3 1 TPR/MLP1/MLP2-like protein PAT1 PF09770.9 ELR19001.1 - 0.012 13.9 12.1 0.014 13.7 12.1 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 AAA_13 PF13166.6 ELR19001.1 - 0.012 14.3 7.9 0.019 13.7 7.9 1.3 1 0 0 1 1 1 0 AAA domain Fez1 PF06818.15 ELR19001.1 - 0.064 13.7 22.0 0.75 10.2 19.6 2.7 2 1 0 2 2 2 0 Fez1 Tropomyosin_1 PF12718.7 ELR19001.1 - 0.067 13.4 20.7 9.8 6.3 0.0 3.5 2 1 1 3 3 3 0 Tropomyosin like DUF4140 PF13600.6 ELR19001.1 - 0.073 13.5 0.2 0.073 13.5 0.2 4.7 3 1 0 3 3 2 0 N-terminal domain of unknown function (DUF4140) DUF4407 PF14362.6 ELR19001.1 - 0.15 11.4 24.1 0.044 13.1 13.2 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) DUF4795 PF16043.5 ELR19001.1 - 0.31 10.6 7.9 0.72 9.4 7.9 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4795) EzrA PF06160.12 ELR19001.1 - 0.32 9.1 10.1 0.71 8.0 9.8 1.7 1 1 0 1 1 1 0 Septation ring formation regulator, EzrA Golgin_A5 PF09787.9 ELR19001.1 - 0.39 10.1 17.2 2.3 7.6 17.2 2.1 1 1 0 1 1 1 0 Golgin subfamily A member 5 V_ATPase_I PF01496.19 ELR19001.1 - 0.47 8.3 3.0 0.72 7.7 3.0 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Atg14 PF10186.9 ELR19001.1 - 0.51 9.4 16.5 1.2 8.1 16.5 1.6 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF2009 PF09418.10 ELR19001.1 - 0.7 8.9 4.3 1 8.3 4.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2009) FAM76 PF16046.5 ELR19001.1 - 0.93 8.8 7.8 1.6 8.0 7.8 1.4 1 0 0 1 1 1 0 FAM76 protein DUF5082 PF16888.5 ELR19001.1 - 1.2 9.4 14.5 9.5 6.5 1.9 3.5 2 1 1 3 3 3 0 Domain of unknown function (DUF5082) CENP-F_leu_zip PF10473.9 ELR19001.1 - 1.2 9.1 19.8 0.83 9.7 13.5 2.9 2 1 1 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 HMMR_N PF15905.5 ELR19001.1 - 1.3 8.4 17.5 0.32 10.4 13.9 1.7 2 0 0 2 2 2 0 Hyaluronan mediated motility receptor N-terminal Fib_alpha PF08702.10 ELR19001.1 - 1.4 9.1 10.4 0.56 10.4 2.3 2.8 2 1 1 3 3 2 0 Fibrinogen alpha/beta chain family Exonuc_VII_L PF02601.15 ELR19001.1 - 1.6 8.2 18.6 4.8 6.7 18.6 1.9 1 1 0 1 1 1 0 Exonuclease VII, large subunit Asp-B-Hydro_N PF05279.11 ELR19001.1 - 1.7 8.7 9.6 2.7 8.0 9.6 1.4 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region ZapB PF06005.12 ELR19001.1 - 2.1 8.8 21.8 0.98 9.9 1.8 3.4 3 1 0 3 3 3 0 Cell division protein ZapB Spc7 PF08317.11 ELR19001.1 - 2.2 7.1 21.6 1.8 7.4 3.8 2.7 2 1 1 3 3 3 0 Spc7 kinetochore protein Sec34 PF04136.15 ELR19001.1 - 2.2 8.1 7.1 0.32 10.9 2.5 1.9 2 0 0 2 2 2 0 Sec34-like family DUF1664 PF07889.12 ELR19001.1 - 2.3 8.3 6.8 0.19 11.7 0.5 2.2 3 0 0 3 3 2 0 Protein of unknown function (DUF1664) DivIC PF04977.15 ELR19001.1 - 3.2 7.6 20.9 0.53 10.1 4.1 4.1 3 1 1 4 4 4 0 Septum formation initiator Leu_zip PF15294.6 ELR19001.1 - 3.6 7.0 12.9 2.9 7.4 11.3 1.6 2 0 0 2 2 1 0 Leucine zipper UPF0242 PF06785.11 ELR19001.1 - 4 7.5 15.9 4.7 7.3 13.9 2.1 2 1 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus DUF948 PF06103.11 ELR19001.1 - 4.2 7.7 5.1 11 6.4 0.9 2.6 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) Tropomyosin PF00261.20 ELR19001.1 - 4.7 6.5 22.2 14 5.0 18.5 2.5 2 1 0 2 2 2 0 Tropomyosin Lebercilin PF15619.6 ELR19001.1 - 4.7 6.8 25.2 2.1 8.0 18.4 2.7 2 1 0 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease SlyX PF04102.12 ELR19001.1 - 4.8 7.9 19.4 35 5.1 2.3 4.9 3 2 2 5 5 5 0 SlyX PDDEXK_9 PF08011.11 ELR19001.1 - 5.3 7.0 5.2 3.4 7.6 0.0 2.6 2 1 1 3 3 3 0 PD-(D/E)XK nuclease superfamily Prismane PF03063.20 ELR19001.1 - 6.6 5.3 6.0 9.2 4.8 6.0 1.1 1 0 0 1 1 1 0 Prismane/CO dehydrogenase family YabA PF06156.13 ELR19001.1 - 8.2 7.1 13.7 13 6.5 1.8 2.7 1 1 0 2 2 2 0 Initiation control protein YabA CSN5_C PF18323.1 ELR19001.1 - 8.6 7.4 14.4 3.8 8.5 5.8 3.4 3 0 0 3 3 3 0 Cop9 signalosome subunit 5 C-terminal domain GAS PF13851.6 ELR19001.1 - 8.7 5.6 20.8 0.41 10.0 6.8 2.7 3 0 0 3 3 3 0 Growth-arrest specific micro-tubule binding SPATA1_C PF15743.5 ELR19001.1 - 9.2 6.3 18.7 0.37 10.9 11.5 2.4 2 1 0 2 2 1 0 Spermatogenesis-associated C-terminus DUF3450 PF11932.8 ELR19001.1 - 9.6 5.4 24.6 0.43 9.8 13.3 2.6 2 1 1 3 3 3 0 Protein of unknown function (DUF3450) KH_1 PF00013.29 ELR19002.1 - 1.3e-34 117.8 7.3 3.8e-19 68.3 2.3 2.6 2 0 0 2 2 2 2 KH domain Ank_4 PF13637.6 ELR19002.1 - 2.7e-19 69.2 1.4 1.1e-11 45.0 0.1 2.8 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 ELR19002.1 - 9.3e-16 57.7 3.5 1.4e-08 34.8 0.1 2.8 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 ELR19002.1 - 1e-13 51.7 0.3 4.4e-13 49.6 0.3 2.0 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 ELR19002.1 - 5.4e-12 44.8 0.1 7.9e-05 22.8 0.0 3.2 3 0 0 3 3 3 2 Ankyrin repeat Ank PF00023.30 ELR19002.1 - 4e-10 39.7 2.7 8.7e-05 22.8 0.1 2.7 2 0 0 2 2 2 2 Ankyrin repeat KH_2 PF07650.17 ELR19002.1 - 1.9e-05 24.4 12.9 0.0048 16.7 0.6 3.2 2 2 1 3 3 3 2 KH domain KH_4 PF13083.6 ELR19002.1 - 0.00015 21.6 3.2 0.1 12.5 0.1 2.6 2 0 0 2 2 2 2 KH domain SLS PF14611.6 ELR19002.1 - 0.0003 20.7 0.0 0.34 10.7 0.0 2.3 1 1 1 2 2 2 2 Mitochondrial inner-membrane-bound regulator Pro_isomerase PF00160.21 ELR19003.1 - 1.1e-46 159.0 0.0 1.3e-46 158.7 0.0 1.1 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD RRM_1 PF00076.22 ELR19004.1 - 1.8e-88 290.4 2.5 8.5e-22 76.8 0.2 4.2 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PABP PF00658.18 ELR19004.1 - 3.1e-21 75.3 0.1 6.4e-21 74.3 0.1 1.5 1 0 0 1 1 1 1 Poly-adenylate binding protein, unique domain RRM_5 PF13893.6 ELR19004.1 - 7.3e-11 41.8 0.0 0.38 10.3 0.0 4.2 2 2 2 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 ELR19004.1 - 4.2e-07 29.7 0.0 0.0044 16.8 0.0 3.8 4 0 0 4 4 4 2 Occluded RNA-recognition motif Nup35_RRM_2 PF14605.6 ELR19004.1 - 7.3e-06 25.9 0.2 2.7 8.0 0.0 4.2 4 0 0 4 4 4 2 Nup53/35/40-type RNA recognition motif DUF4523 PF15023.6 ELR19004.1 - 0.0013 18.6 0.0 4.4 7.1 0.0 3.9 3 1 0 4 4 4 1 Protein of unknown function (DUF4523) DUF5526 PF17664.1 ELR19004.1 - 0.0025 17.4 0.9 0.0049 16.5 0.9 1.4 1 0 0 1 1 1 1 Family of unknown function (DUF5526) SET_assoc PF11767.8 ELR19004.1 - 0.0031 17.1 0.1 14 5.4 0.0 3.9 4 0 0 4 4 4 1 Histone lysine methyltransferase SET associated OB_RNB PF08206.11 ELR19004.1 - 0.0043 16.7 0.6 0.49 10.1 0.0 2.9 3 0 0 3 3 3 1 Ribonuclease B OB domain RRM_7 PF16367.5 ELR19004.1 - 0.0087 16.2 0.1 8.8 6.5 0.0 4.0 4 1 0 4 4 4 1 RNA recognition motif GNAT_acetyltran PF12746.7 ELR19004.1 - 0.04 13.5 0.3 0.082 12.5 0.1 1.6 2 0 0 2 2 2 0 GNAT acetyltransferase RRM_8 PF11835.8 ELR19004.1 - 0.087 13.0 0.0 9.2 6.6 0.0 3.0 3 0 0 3 3 3 0 RRM-like domain Limkain-b1 PF11608.8 ELR19004.1 - 0.13 12.4 0.9 29 4.8 0.1 3.7 4 0 0 4 4 4 0 Limkain b1 LRIF1 PF15741.5 ELR19005.1 - 0.077 11.5 16.9 0.1 11.1 16.9 1.2 1 0 0 1 1 1 0 Ligand-dependent nuclear receptor-interacting factor 1 SieB PF14163.6 ELR19005.1 - 0.75 9.3 2.6 1.5 8.3 2.6 1.4 1 0 0 1 1 1 0 Super-infection exclusion protein B MDFI PF15316.6 ELR19005.1 - 7.1 6.7 13.9 20 5.2 13.9 1.8 1 0 0 1 1 1 0 MyoD family inhibitor Rhomboid PF01694.22 ELR19006.1 - 7.5e-27 94.2 14.0 6.9e-26 91.0 14.0 2.2 1 1 0 1 1 1 1 Rhomboid family Complex1_LYR PF05347.15 ELR19007.1 - 1.4e-09 37.8 0.1 2.3e-09 37.2 0.1 1.3 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_2 PF13233.6 ELR19007.1 - 0.0004 21.1 0.2 0.00048 20.8 0.2 1.1 1 0 0 1 1 1 1 Complex1_LYR-like AAA_lid_7 PF17867.1 ELR19007.1 - 0.0021 18.2 0.0 0.0026 18.0 0.0 1.2 1 0 0 1 1 1 1 Midasin AAA lid domain WH1 PF00568.23 ELR19008.1 - 3.6e-17 62.3 0.0 5.4e-17 61.7 0.0 1.2 1 0 0 1 1 1 1 WH1 domain PBD PF00786.28 ELR19008.1 - 3.7e-15 56.0 0.1 6.5e-15 55.2 0.1 1.4 1 0 0 1 1 1 1 P21-Rho-binding domain DUF1325 PF07039.11 ELR19009.1 - 4e-15 56.1 0.2 6.5e-15 55.4 0.2 1.3 1 0 0 1 1 1 1 SGF29 tudor-like domain DUF4537 PF15057.6 ELR19009.1 - 0.02 14.9 0.1 0.13 12.2 0.0 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4537) BUD22 PF09073.10 ELR19010.1 - 0.00011 21.7 9.3 0.00013 21.5 9.3 1.1 1 0 0 1 1 1 1 BUD22 SR-25 PF10500.9 ELR19010.1 - 0.012 15.2 16.5 0.017 14.8 16.5 1.4 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein NPR3 PF03666.13 ELR19010.1 - 0.12 11.1 7.8 0.15 10.8 7.8 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Paramyxo_ncap PF00973.19 ELR19010.1 - 0.74 8.7 5.7 0.92 8.3 5.7 1.1 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein Med19 PF10278.9 ELR19010.1 - 0.9 9.5 19.3 1.6 8.6 19.3 1.4 1 0 0 1 1 1 0 Mediator of RNA pol II transcription subunit 19 Peptidase_S49_N PF08496.10 ELR19010.1 - 1.2 9.2 11.4 2.2 8.3 11.4 1.5 1 0 0 1 1 1 0 Peptidase family S49 N-terminal DUF3824 PF12868.7 ELR19010.1 - 3.8 8.2 11.3 5.7 7.6 11.3 1.3 1 0 0 1 1 1 0 Domain of unknwon function (DUF3824) BORG_CEP PF14957.6 ELR19010.1 - 5.6 8.2 8.8 8.4 7.6 8.7 1.5 1 1 0 1 1 1 0 Cdc42 effector PP2C PF00481.21 ELR19011.1 - 5.1e-36 124.6 8.4 2.6e-14 53.5 0.0 4.6 5 0 0 5 5 5 3 Protein phosphatase 2C SIR4_SID PF16991.5 ELR19011.1 - 6.5 6.8 8.3 0.56 10.3 2.2 2.3 2 0 0 2 2 2 0 Sir4 SID domain Vfa1 PF08432.10 ELR19012.1 - 0.96 9.8 22.3 0.11 12.8 16.7 2.1 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 MCM_bind PF09739.9 ELR19012.1 - 6.1 5.2 6.7 9.1 4.6 6.7 1.2 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor NPR3 PF03666.13 ELR19012.1 - 8.6 5.0 12.1 15 4.2 12.1 1.3 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Metallophos PF00149.28 ELR19014.1 - 4e-33 115.7 0.1 6.4e-33 115.0 0.1 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase PPP5 PF08321.12 ELR19014.1 - 1.7e-26 92.3 0.0 3.3e-26 91.4 0.0 1.5 1 0 0 1 1 1 1 PPP5 TPR repeat region TPR_1 PF00515.28 ELR19014.1 - 6.1e-10 38.5 5.5 2.8e-05 23.7 0.0 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 ELR19014.1 - 9.1e-09 34.8 4.6 8.1e-05 22.4 0.0 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.6 ELR19014.1 - 2.7e-05 23.7 0.2 0.00069 19.2 0.1 2.6 1 1 1 2 2 2 1 TPR repeat TPR_8 PF13181.6 ELR19014.1 - 5.2e-05 23.1 7.5 0.019 15.1 0.0 3.1 3 0 0 3 3 2 2 Tetratricopeptide repeat TPR_17 PF13431.6 ELR19014.1 - 0.0025 18.1 0.0 0.0067 16.7 0.0 1.8 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_16 PF13432.6 ELR19014.1 - 0.0053 17.4 0.1 0.011 16.3 0.1 1.6 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_14 PF13428.6 ELR19014.1 - 0.024 15.4 0.1 0.14 13.1 0.0 2.4 1 1 2 3 3 3 0 Tetratricopeptide repeat TPR_9 PF13371.6 ELR19014.1 - 0.032 14.4 0.0 0.055 13.6 0.0 1.3 1 0 0 1 1 1 0 Tetratricopeptide repeat DUF3791 PF12668.7 ELR19014.1 - 0.056 13.5 0.1 0.18 11.8 0.1 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF3791) Adeno_PV PF03910.13 ELR19015.1 - 0.11 11.2 3.8 0.1 11.3 3.8 1.0 1 0 0 1 1 1 0 Adenovirus minor core protein PV 4HBT PF03061.22 ELR19016.1 - 2.7e-05 24.4 0.5 0.00033 20.9 0.5 2.2 1 1 0 1 1 1 1 Thioesterase superfamily BBP2 PF07642.11 ELR19016.1 - 0.1 11.7 0.0 0.12 11.5 0.0 1.1 1 0 0 1 1 1 0 Putative beta-barrel porin-2, OmpL-like. bbp2 RNA_ligase PF09414.10 ELR19017.1 - 9.5e-18 65.0 0.0 1.4e-17 64.4 0.0 1.3 1 0 0 1 1 1 1 RNA ligase T4_Rnl2_C PF18043.1 ELR19017.1 - 1e-09 38.4 0.0 1.7e-09 37.7 0.0 1.3 1 0 0 1 1 1 1 T4 RNA ligase 2 C-terminal GST_C_3 PF14497.6 ELR19018.1 - 8e-18 64.5 0.0 1.2e-17 63.9 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 ELR19018.1 - 3.2e-10 40.1 0.0 6.3e-10 39.2 0.0 1.5 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 ELR19018.1 - 0.00031 21.0 0.0 0.00067 19.9 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 ELR19018.1 - 0.007 16.4 0.1 0.022 14.8 0.0 1.9 2 1 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 ELR19018.1 - 0.023 15.1 0.0 0.038 14.4 0.0 1.3 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain GST_C_5 PF16865.5 ELR19018.1 - 0.13 12.8 0.0 0.21 12.2 0.0 1.4 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain EamA PF00892.20 ELR19019.1 - 2.8e-38 131.2 43.8 1.2e-20 74.1 14.4 2.1 2 0 0 2 2 2 2 EamA-like transporter family Nuc_sug_transp PF04142.15 ELR19019.1 - 0.0086 15.3 8.5 0.011 15.0 0.9 2.9 2 1 0 2 2 2 2 Nucleotide-sugar transporter Ank_2 PF12796.7 ELR19020.1 - 1.8e-29 102.2 0.6 1.4e-11 44.8 0.4 3.5 2 2 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ELR19020.1 - 5.7e-27 93.7 2.8 3.3e-07 30.7 0.0 5.2 2 1 3 5 5 5 5 Ankyrin repeats (many copies) Ank PF00023.30 ELR19020.1 - 4.2e-23 80.7 5.5 0.00032 21.0 0.3 7.9 7 1 0 7 7 7 6 Ankyrin repeat Ank_3 PF13606.6 ELR19020.1 - 4.8e-23 78.7 5.0 0.0095 16.4 0.0 7.5 7 0 0 7 7 7 7 Ankyrin repeat Ank_5 PF13857.6 ELR19020.1 - 2.4e-18 66.0 8.6 1.1e-07 32.0 0.1 5.4 2 2 3 5 5 5 5 Ankyrin repeats (many copies) DpaA_N PF16924.5 ELR19020.1 - 0.17 12.0 0.3 3.2 7.9 0.0 2.7 3 0 0 3 3 3 0 Dipicolinate synthase subunit A N-terminal domain Hydrolase_4 PF12146.8 ELR19021.1 - 1.2e-54 185.2 0.9 1.9e-29 102.6 0.0 2.1 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 ELR19021.1 - 0.00021 21.0 0.1 0.0023 17.6 0.1 2.1 2 0 0 2 2 2 1 alpha/beta hydrolase fold AXE1 PF05448.12 ELR19021.1 - 0.0025 16.5 0.0 0.017 13.8 0.0 1.9 2 0 0 2 2 2 1 Acetyl xylan esterase (AXE1) Abhydrolase_6 PF12697.7 ELR19021.1 - 0.035 14.7 7.9 0.14 12.7 7.8 2.1 1 1 0 1 1 1 0 Alpha/beta hydrolase family CAP PF00188.26 ELR19022.1 - 3e-18 66.9 3.7 3e-18 66.9 3.7 1.9 2 0 0 2 2 2 1 Cysteine-rich secretory protein family fn3_3 PF14686.6 ELR19022.1 - 0.02 14.7 6.1 0.02 14.7 6.1 2.7 3 1 0 3 3 3 0 Polysaccharide lyase family 4, domain II TetR_C_32 PF09209.11 ELR19025.1 - 0.031 14.3 0.3 0.15 12.0 0.1 2.0 1 1 1 2 2 2 0 Tetracyclin repressor-like, C-terminal domain Thioredoxin PF00085.20 ELR19026.1 - 1e-11 44.8 0.0 1.2e-11 44.5 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin DIM1 PF02966.16 ELR19026.1 - 0.0007 19.4 0.1 0.00084 19.1 0.1 1.1 1 0 0 1 1 1 1 Mitosis protein DIM1 DUF2847 PF11009.8 ELR19026.1 - 0.0027 17.6 0.1 0.0035 17.2 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2847) OST3_OST6 PF04756.13 ELR19026.1 - 0.0042 16.5 0.0 0.0044 16.4 0.0 1.1 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family Thioredoxin_8 PF13905.6 ELR19026.1 - 0.0078 16.5 0.1 0.35 11.2 0.0 2.1 1 1 1 2 2 2 1 Thioredoxin-like HyaE PF07449.11 ELR19026.1 - 0.022 14.7 0.0 0.031 14.2 0.0 1.3 1 0 0 1 1 1 0 Hydrogenase-1 expression protein HyaE Thioredoxin_2 PF13098.6 ELR19026.1 - 0.12 12.9 0.0 0.16 12.4 0.0 1.3 1 0 0 1 1 1 0 Thioredoxin-like domain RasGEF PF00617.19 ELR19028.1 - 2e-36 125.9 2.6 2.2e-36 125.7 2.6 1.0 1 0 0 1 1 1 1 RasGEF domain Glyco_transf_64 PF09258.10 ELR19029.1 - 1.2e-16 60.7 0.5 1.9e-16 60.1 0.5 1.3 1 1 0 1 1 1 1 Glycosyl transferase family 64 domain Rap_GAP PF02145.15 ELR19030.1 - 1.4e-44 151.9 0.1 4.8e-44 150.1 0.1 1.8 1 1 0 1 1 1 1 Rap/ran-GAP TLD PF07534.16 ELR19032.1 - 2.4e-24 86.1 0.0 3.3e-24 85.7 0.0 1.2 1 0 0 1 1 1 1 TLD zf-C2HC_2 PF13913.6 ELR19032.1 - 1.7e-06 27.8 0.3 4.5e-06 26.4 0.3 1.7 1 0 0 1 1 1 1 zinc-finger of a C2HC-type RNF220 PF15926.5 ELR19032.1 - 0.012 15.3 0.2 0.018 14.7 0.2 1.3 1 0 0 1 1 1 0 E3 ubiquitin-protein ligase RNF220 Rad50_zn_hook PF04423.14 ELR19032.1 - 0.025 14.4 0.4 0.025 14.4 0.4 1.8 2 1 0 2 2 2 0 Rad50 zinc hook motif Dehydrin PF00257.19 ELR19032.1 - 0.029 14.9 2.8 0.049 14.2 2.8 1.3 1 0 0 1 1 1 0 Dehydrin IMUP PF15761.5 ELR19032.1 - 0.044 14.5 0.8 0.066 13.9 0.8 1.3 1 0 0 1 1 1 0 Immortalisation up-regulated protein TRAF6_Z2 PF18048.1 ELR19032.1 - 0.055 13.6 0.4 0.095 12.8 0.4 1.4 1 0 0 1 1 1 0 TNF receptor-associated factor 6 zinc finger 2 DUF2225 PF09986.9 ELR19032.1 - 0.11 12.2 0.2 0.15 11.8 0.2 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2225) UBZ_FAAP20 PF15750.5 ELR19032.1 - 0.14 12.1 1.8 0.56 10.2 0.2 2.4 2 0 0 2 2 2 0 Ubiquitin-binding zinc-finger SR-25 PF10500.9 ELR19032.1 - 0.17 11.5 2.2 0.23 11.0 2.2 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein zf-WRNIP1_ubi PF18279.1 ELR19032.1 - 0.22 12.2 0.5 0.38 11.5 0.1 1.7 1 1 0 1 1 1 0 Werner helicase-interacting protein 1 ubiquitin-binding domain HAT_KAT11 PF08214.11 ELR19033.1 - 0.058 12.7 0.1 0.07 12.4 0.1 1.3 1 1 0 1 1 1 0 Histone acetylation protein DUF4724 PF15852.5 ELR19033.1 - 2.5 8.7 4.7 3.4 8.2 3.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4724) CtIP_N PF10482.9 ELR19034.1 - 0.028 14.5 0.0 0.044 13.8 0.0 1.4 1 1 0 1 1 1 0 Tumour-suppressor protein CtIP N-terminal domain DBINO PF13892.6 ELR19036.1 - 0.069 13.5 0.4 0.11 12.9 0.4 1.2 1 0 0 1 1 1 0 DNA-binding domain RUN PF02759.19 ELR19037.1 - 1.4e-16 60.7 0.0 1.8e-16 60.3 0.0 1.1 1 0 0 1 1 1 1 RUN domain TetR_C_3 PF08362.11 ELR19037.1 - 0.054 13.4 0.2 0.14 12.1 0.0 1.7 2 0 0 2 2 2 0 YcdC-like protein, C-terminal region DUF2967 PF11179.8 ELR19039.1 - 0.1 10.7 0.6 0.15 10.1 0.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2967) PheRS_DBD3 PF18553.1 ELR19040.1 - 1.3e-06 28.5 0.0 4.4e-06 26.9 0.0 1.9 1 0 0 1 1 1 1 PheRS DNA binding domain 3 Ribosomal_60s PF00428.19 ELR19040.1 - 3.2 8.4 10.7 5.8 7.6 8.4 2.2 2 0 0 2 2 2 0 60s Acidic ribosomal protein PheRS_DBD3 PF18553.1 ELR19041.1 - 3.2e-06 27.3 0.0 8.9e-06 25.9 0.0 1.8 1 0 0 1 1 1 1 PheRS DNA binding domain 3 HSP70 PF00012.20 ELR19042.1 - 3.1e-05 22.4 0.1 0.00046 18.5 0.1 1.9 1 1 1 2 2 2 2 Hsp70 protein SPRY PF00622.28 ELR19043.1 - 2.7e-09 37.2 0.2 0.0019 18.3 0.1 2.4 2 0 0 2 2 2 2 SPRY domain Spike_torovirin PF17072.5 ELR19043.1 - 0.071 10.3 0.3 0.097 9.8 0.3 1.0 1 0 0 1 1 1 0 Torovirinae spike glycoprotein PDCD7 PF16021.5 ELR19043.1 - 1.9 7.6 7.8 1.4 7.9 3.2 2.1 2 0 0 2 2 2 0 Programmed cell death protein 7 RRM_1 PF00076.22 ELR19044.1 - 1.4e-05 24.8 0.0 3e-05 23.8 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DDE_Tnp_Tn3 PF01526.17 ELR19044.1 - 0.013 14.3 1.5 0.013 14.3 1.5 1.9 1 1 1 2 2 2 0 Tn3 transposase DDE domain Nup35_RRM_2 PF14605.6 ELR19044.1 - 0.11 12.5 0.0 0.26 11.3 0.0 1.7 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif EF-1_beta_acid PF10587.9 ELR19046.1 - 0.12 12.8 0.8 0.12 12.8 0.8 6.5 5 1 1 6 6 6 0 Eukaryotic elongation factor 1 beta central acidic region Peptidase_S64 PF08192.11 ELR19046.1 - 1.2 7.5 12.5 2 6.8 12.5 1.3 1 0 0 1 1 1 0 Peptidase family S64 DUF4407 PF14362.6 ELR19046.1 - 1.9 7.8 12.2 2.6 7.3 12.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Folate_rec PF03024.14 ELR19047.1 - 0.00077 19.4 0.3 0.0017 18.2 0.3 1.6 1 1 0 1 1 1 1 Folate receptor family CIMR PF00878.18 ELR19048.1 - 2.8e-11 43.7 0.1 4.9e-05 23.4 0.1 3.0 2 1 1 3 3 3 2 Cation-independent mannose-6-phosphate receptor repeat Folate_rec PF03024.14 ELR19048.1 - 1.3e-06 28.4 3.2 4.5e-06 26.7 3.2 1.9 1 0 0 1 1 1 1 Folate receptor family Ephrin_rec_like PF07699.13 ELR19048.1 - 1.1e-05 25.1 38.3 1.6e-05 24.6 3.5 6.6 5 1 1 6 6 6 4 Putative ephrin-receptor like Ephrin_rec_like PF07699.13 ELR19049.1 - 8.6e-10 38.2 43.1 0.015 15.1 7.1 7.3 4 3 2 6 6 6 5 Putative ephrin-receptor like CIMR PF00878.18 ELR19049.1 - 0.07 13.2 0.1 0.25 11.4 0.0 1.9 2 0 0 2 2 2 0 Cation-independent mannose-6-phosphate receptor repeat NCD3G PF07562.14 ELR19049.1 - 0.13 12.3 37.9 0.022 14.7 2.6 6.8 6 2 2 8 8 8 0 Nine Cysteines Domain of family 3 GPCR SH3_2 PF07653.17 ELR19050.1 - 1.8e-05 24.3 0.1 3.4e-05 23.5 0.1 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.6 ELR19050.1 - 0.00023 21.0 0.0 0.00039 20.2 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 ELR19050.1 - 0.0053 16.3 0.0 0.01 15.4 0.0 1.4 1 0 0 1 1 1 1 SH3 domain PUL PF08324.11 ELR19051.1 - 2.8e-39 135.0 0.8 3.7e-39 134.6 0.8 1.1 1 0 0 1 1 1 1 PUL domain PFU PF09070.11 ELR19051.1 - 0.017 15.3 0.0 0.037 14.3 0.0 1.5 1 0 0 1 1 1 0 PFU (PLAA family ubiquitin binding) DUF3390 PF11870.8 ELR19051.1 - 0.097 13.0 0.1 30 5.1 0.1 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF3390) OTU PF02338.19 ELR19052.1 - 6.3e-14 52.6 0.0 1.2e-13 51.7 0.0 1.4 1 0 0 1 1 1 1 OTU-like cysteine protease DMAP1 PF05499.12 ELR19052.1 - 0.33 10.8 4.3 0.52 10.2 4.3 1.3 1 0 0 1 1 1 0 DNA methyltransferase 1-associated protein 1 (DMAP1) PP2C PF00481.21 ELR19053.1 - 1.3e-40 139.6 0.0 2e-40 139.1 0.0 1.2 1 0 0 1 1 1 1 Protein phosphatase 2C LRR_8 PF13855.6 ELR19053.1 - 3.5e-35 119.6 68.9 1.8e-09 37.2 1.6 5.4 1 1 7 8 8 8 8 Leucine rich repeat LRR_4 PF12799.7 ELR19053.1 - 8.3e-25 86.5 30.0 3.8e-05 24.0 3.9 6.8 5 1 4 9 9 9 7 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 ELR19053.1 - 0.00011 22.2 18.1 28 5.8 0.1 9.5 10 0 0 10 10 10 0 Leucine Rich Repeat PP2C_2 PF13672.6 ELR19053.1 - 0.0006 19.5 0.1 0.0011 18.7 0.1 1.3 1 0 0 1 1 1 1 Protein phosphatase 2C SpoIIE PF07228.12 ELR19053.1 - 0.0014 18.5 0.9 0.017 15.0 0.4 2.8 2 1 0 2 2 2 1 Stage II sporulation protein E (SpoIIE) LRR_9 PF14580.6 ELR19053.1 - 0.0022 17.5 16.6 0.017 14.7 1.2 3.8 1 1 3 4 4 4 2 Leucine-rich repeat DDA1 PF10172.9 ELR19054.1 - 7e-18 64.7 0.0 1.9e-17 63.3 0.0 1.8 1 0 0 1 1 1 1 Det1 complexing ubiquitin ligase Nop14 PF04147.12 ELR19054.1 - 0.12 10.6 21.8 0.13 10.5 21.8 1.0 1 0 0 1 1 1 0 Nop14-like family CDC27 PF09507.10 ELR19054.1 - 1.1 8.6 30.4 1.3 8.4 30.4 1.0 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 RR_TM4-6 PF06459.12 ELR19054.1 - 3.7 7.3 20.6 4.3 7.1 20.6 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 MRG PF05712.13 ELR19055.1 - 3.8e-37 127.5 0.0 6.1e-37 126.8 0.0 1.3 1 0 0 1 1 1 1 MRG Tudor-knot PF11717.8 ELR19055.1 - 1.7e-09 37.4 1.1 4.3e-09 36.1 1.1 1.7 1 0 0 1 1 1 1 RNA binding activity-knot of a chromodomain RRM_1 PF00076.22 ELR19056.1 - 3.8e-38 129.2 0.0 2.6e-19 68.8 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 ELR19056.1 - 0.00077 19.5 0.0 0.009 16.1 0.0 2.2 2 0 0 2 2 2 1 RNA recognition motif RRM_5 PF13893.6 ELR19056.1 - 0.0014 18.2 0.0 0.0082 15.7 0.0 2.0 1 1 1 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) OB_RNB PF08206.11 ELR19056.1 - 0.0019 17.8 0.6 0.19 11.4 0.0 2.6 2 1 0 2 2 2 1 Ribonuclease B OB domain XYPPX PF02162.17 ELR19056.1 - 0.014 15.2 6.3 0.014 15.2 6.3 5.3 5 0 0 5 5 5 0 XYPPX repeat (two copies) PHM7_cyt PF14703.6 ELR19056.1 - 0.03 14.5 0.0 3.6 7.8 0.0 2.1 2 0 0 2 2 2 0 Cytosolic domain of 10TM putative phosphate transporter Limkain-b1 PF11608.8 ELR19056.1 - 0.054 13.6 0.1 3.6 7.7 0.0 2.2 2 0 0 2 2 2 0 Limkain b1 Cas_Cas2CT1978 PF09707.10 ELR19056.1 - 0.12 12.5 0.0 6.1 7.0 0.0 2.2 2 0 0 2 2 2 0 CRISPR-associated protein (Cas_Cas2CT1978) DNA_pol_phi PF04931.13 ELR19057.1 - 1.4e-144 483.1 24.9 1.4e-144 483.1 24.9 3.1 4 0 0 4 4 4 1 DNA polymerase phi Nop14 PF04147.12 ELR19057.1 - 2.8e-05 22.6 25.8 2.8e-05 22.6 25.8 4.3 4 1 0 4 4 4 1 Nop14-like family DNA_photolyase PF00875.18 ELR19058.1 - 5.7e-32 111.0 0.0 1.1e-31 110.0 0.0 1.5 1 0 0 1 1 1 1 DNA photolyase Cnd2 PF05786.14 ELR19058.1 - 0.0023 16.7 10.6 0.0038 16.0 10.6 1.3 1 0 0 1 1 1 1 Condensin complex subunit 2 RXT2_N PF08595.11 ELR19058.1 - 0.21 11.6 8.0 0.52 10.3 8.0 1.6 1 0 0 1 1 1 0 RXT2-like, N-terminal Pox_Ag35 PF03286.14 ELR19058.1 - 0.21 11.4 16.3 0.53 10.1 16.3 1.6 1 0 0 1 1 1 0 Pox virus Ag35 surface protein NOA36 PF06524.12 ELR19058.1 - 0.47 9.7 10.8 0.91 8.8 10.8 1.4 1 0 0 1 1 1 0 NOA36 protein Myc_N PF01056.18 ELR19058.1 - 0.66 9.8 10.4 1.4 8.8 10.4 1.4 1 0 0 1 1 1 0 Myc amino-terminal region Pkinase_fungal PF17667.1 ELR19058.1 - 0.73 8.5 4.7 1.2 7.8 4.7 1.2 1 0 0 1 1 1 0 Fungal protein kinase PBP1_TM PF14812.6 ELR19058.1 - 0.76 10.2 20.3 0.17 12.3 13.8 2.7 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal FancD2 PF14631.6 ELR19058.1 - 0.87 6.9 11.9 1.2 6.5 11.9 1.1 1 0 0 1 1 1 0 Fanconi anaemia protein FancD2 nuclease Sporozoite_P67 PF05642.11 ELR19058.1 - 1.6 6.7 11.7 2.2 6.2 11.7 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen DUF913 PF06025.12 ELR19058.1 - 3.1 6.7 8.2 5.4 5.9 8.2 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) DNA_pol_phi PF04931.13 ELR19058.1 - 5.9 4.9 15.4 10 4.1 15.4 1.3 1 0 0 1 1 1 0 DNA polymerase phi FRG PF08867.11 ELR19058.1 - 6.4 7.8 12.2 0.69 10.9 0.4 3.9 3 1 1 4 4 4 0 FRG domain DUF3464 PF11947.8 ELR19058.1 - 9 6.0 11.8 30 4.3 9.8 2.4 2 0 0 2 2 2 0 Photosynthesis affected mutant 68 S-antigen PF05756.11 ELR19058.1 - 9.1 6.7 7.2 26 5.2 7.2 1.8 1 0 0 1 1 1 0 S-antigen protein SpoIIIAH PF12685.7 ELR19058.1 - 9.8 5.9 15.3 2.9 7.7 11.9 1.8 2 0 0 2 2 2 0 SpoIIIAH-like protein Rap_GAP PF02145.15 ELR19059.1 - 3.5e-49 166.9 0.0 1.3e-34 119.4 0.1 2.1 1 1 1 2 2 2 2 Rap/ran-GAP Mito_carr PF00153.27 ELR19061.1 - 8.7e-48 160.2 1.5 2.9e-21 75.2 0.0 3.3 3 1 0 3 3 3 3 Mitochondrial carrier protein Calpain_III PF01067.22 ELR19063.1 - 7.8e-77 256.3 0.0 2e-16 60.6 0.0 7.8 6 2 0 6 6 6 6 Calpain large subunit, domain III Peptidase_C2 PF00648.21 ELR19063.1 - 5.7e-72 242.2 0.1 2.7e-71 240.0 0.1 2.0 1 1 0 1 1 1 1 Calpain family cysteine protease p450 PF00067.22 ELR19064.1 - 1e-85 288.2 0.0 1.3e-85 287.9 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 HMG_box PF00505.19 ELR19065.1 - 5.7e-22 77.9 2.8 5.7e-22 77.9 2.8 2.0 2 0 0 2 2 2 1 HMG (high mobility group) box HMG_box_2 PF09011.10 ELR19065.1 - 3.2e-21 75.7 4.1 1.3e-20 73.7 4.1 2.1 1 0 0 1 1 1 1 HMG-box domain YABBY PF04690.13 ELR19065.1 - 1.7 9.2 15.6 0.18 12.3 9.5 2.1 1 1 1 2 2 2 0 YABBY protein Peptidase_M28 PF04389.17 ELR19067.1 - 3.4e-37 128.0 0.0 5.4e-37 127.4 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M28 Peptidase_M20 PF01546.28 ELR19067.1 - 1.1e-08 35.0 0.3 6.9e-08 32.4 0.3 2.0 1 1 0 1 1 1 1 Peptidase family M20/M25/M40 Peptidase_M42 PF05343.14 ELR19067.1 - 0.015 14.3 0.0 0.053 12.5 0.0 1.8 2 0 0 2 2 2 0 M42 glutamyl aminopeptidase Phage_cap_E PF03864.15 ELR19067.1 - 0.022 14.0 0.0 0.035 13.3 0.0 1.2 1 0 0 1 1 1 0 Phage major capsid protein E AP3B1_C PF14796.6 ELR19068.1 - 0.00089 19.5 0.1 0.0022 18.3 0.1 1.6 2 0 0 2 2 2 1 Clathrin-adaptor complex-3 beta-1 subunit C-terminal Ribosomal_L28e PF01778.17 ELR19069.1 - 3.6e-14 53.5 1.0 3.6e-14 53.5 1.0 1.8 1 1 1 2 2 2 1 Ribosomal L28e protein family Ribosomal_L28e PF01778.17 ELR19070.1 - 2e-24 86.5 0.6 2e-24 86.5 0.6 1.7 1 1 1 2 2 2 1 Ribosomal L28e protein family Tho1_MOS11_C PF18592.1 ELR19071.1 - 2.1e-05 24.3 26.9 0.13 12.1 4.9 4.6 2 1 2 4 4 4 4 Tho1/MOS11 C-terminal domain Nucleoporin_FG PF13634.6 ELR19071.1 - 0.35 11.8 6.2 0.74 10.7 6.2 1.7 1 1 0 1 1 1 0 Nucleoporin FG repeat region UBA PF00627.31 ELR19072.1 - 1.5e-14 53.5 5.3 2.6e-07 30.4 0.2 3.3 3 0 0 3 3 3 2 UBA/TS-N domain STI1 PF17830.1 ELR19072.1 - 1.8e-06 27.8 0.0 3e-06 27.0 0.0 1.3 1 0 0 1 1 1 1 STI1 domain ubiquitin PF00240.23 ELR19072.1 - 0.076 12.8 0.0 0.15 11.9 0.0 1.4 1 0 0 1 1 1 0 Ubiquitin family HOIP-UBA PF16678.5 ELR19072.1 - 0.12 12.4 0.7 1.1 9.3 0.0 2.5 2 1 0 2 2 2 0 HOIP UBA domain pair KH_1 PF00013.29 ELR19073.1 - 4.2e-10 39.3 0.0 1.5e-07 31.1 0.0 2.3 2 0 0 2 2 2 2 KH domain PX PF00787.24 ELR19075.1 - 2.1e-05 24.5 0.2 4.9e-05 23.3 0.2 1.6 1 0 0 1 1 1 1 PX domain PVL_ORF50 PF07768.11 ELR19075.1 - 0.14 12.5 3.2 0.31 11.3 3.2 1.6 1 0 0 1 1 1 0 PVL ORF-50-like family Nop PF01798.18 ELR19076.1 - 0.0007 19.1 0.1 0.00073 19.1 0.1 1.0 1 0 0 1 1 1 1 snoRNA binding domain, fibrillarin Mito_carr PF00153.27 ELR19077.1 - 4e-72 238.2 3.5 8e-25 86.6 0.0 3.9 4 0 0 4 4 4 3 Mitochondrial carrier protein EF-hand_7 PF13499.6 ELR19077.1 - 1.3e-12 48.0 0.9 0.00024 21.5 0.0 3.6 3 0 0 3 3 3 3 EF-hand domain pair EF-hand_8 PF13833.6 ELR19077.1 - 1.7e-09 37.3 2.9 1.4e-05 24.8 0.1 3.5 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_1 PF00036.32 ELR19077.1 - 4.8e-08 32.0 4.1 0.004 16.6 0.0 5.3 5 0 0 5 5 5 2 EF hand EF-hand_6 PF13405.6 ELR19077.1 - 4.1e-07 29.4 8.0 0.051 13.5 0.1 6.0 6 0 0 6 6 6 3 EF-hand domain EF-hand_5 PF13202.6 ELR19077.1 - 0.00054 19.3 5.8 0.015 14.8 0.1 3.7 4 0 0 4 4 4 2 EF hand Serine_protease PF18405.1 ELR19077.1 - 0.11 11.6 0.4 5.2 6.1 0.0 2.6 3 0 0 3 3 3 0 Gammaproteobacterial serine protease F-box-like PF12937.7 ELR19078.1 - 1.6e-10 40.7 0.9 4.1e-10 39.4 0.9 1.7 1 0 0 1 1 1 1 F-box-like TPR_1 PF00515.28 ELR19078.1 - 1.7e-07 30.8 0.5 0.078 12.8 0.0 3.9 4 1 1 5 5 5 2 Tetratricopeptide repeat TPR_2 PF07719.17 ELR19078.1 - 3.1e-07 30.0 1.3 0.044 13.9 0.3 4.9 3 2 2 5 5 5 2 Tetratricopeptide repeat F-box PF00646.33 ELR19078.1 - 1.5e-05 24.7 0.3 2.7e-05 23.9 0.3 1.4 1 0 0 1 1 1 1 F-box domain TPR_8 PF13181.6 ELR19078.1 - 0.00073 19.6 3.9 0.029 14.6 0.1 3.8 4 0 0 4 4 4 1 Tetratricopeptide repeat Elongin_A PF06881.11 ELR19078.1 - 0.0026 18.2 0.7 0.0066 16.9 0.2 1.9 2 0 0 2 2 2 1 RNA polymerase II transcription factor SIII (Elongin) subunit A TPR_12 PF13424.6 ELR19078.1 - 0.0089 16.3 3.8 18 5.7 0.2 4.4 2 1 1 3 3 3 0 Tetratricopeptide repeat DUF3856 PF12968.7 ELR19078.1 - 0.012 15.7 0.8 0.051 13.6 0.8 2.1 1 1 0 1 1 1 0 Domain of Unknown Function (DUF3856) TPR_16 PF13432.6 ELR19078.1 - 0.027 15.1 8.5 16 6.2 0.2 5.2 4 1 1 5 5 5 0 Tetratricopeptide repeat TPR_14 PF13428.6 ELR19078.1 - 0.045 14.6 12.5 2 9.5 0.1 5.3 4 2 1 5 5 5 0 Tetratricopeptide repeat TPR_7 PF13176.6 ELR19078.1 - 0.058 13.4 4.8 1.6 8.9 0.0 4.2 4 1 0 4 4 4 0 Tetratricopeptide repeat TPR_10 PF13374.6 ELR19078.1 - 0.41 10.6 0.1 0.41 10.6 0.1 4.1 4 1 1 5 5 5 0 Tetratricopeptide repeat Usp PF00582.26 ELR19079.1 - 3.2e-17 63.4 1.1 2e-14 54.3 0.3 2.1 1 1 1 2 2 2 2 Universal stress protein family YccF PF03733.13 ELR19080.1 - 4.5e-16 59.3 34.1 4.4e-09 36.9 10.2 2.1 2 0 0 2 2 2 2 Inner membrane component domain SH PF01445.17 ELR19080.1 - 0.045 13.7 2.1 0.14 12.1 2.1 1.8 1 0 0 1 1 1 0 Viral small hydrophobic protein PrgI PF12666.7 ELR19080.1 - 0.25 12.1 8.4 1.8 9.4 3.4 2.3 2 0 0 2 2 2 0 PrgI family protein DUF3930 PF13067.6 ELR19080.1 - 0.71 10.2 0.2 0.71 10.2 0.2 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3930) Pro_isomerase PF00160.21 ELR19081.1 - 8.1e-53 178.9 0.1 9.8e-53 178.7 0.1 1.1 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD TAF6_C PF07571.13 ELR19082.1 - 0.048 14.0 6.6 6 7.3 0.2 3.8 3 1 0 3 3 3 0 TAF6 C-terminal HEAT repeat domain HTH_AraC PF00165.23 ELR19082.1 - 0.53 10.5 29.7 0.48 10.6 0.6 4.9 5 0 0 5 5 5 0 Bacterial regulatory helix-turn-helix proteins, AraC family LIM PF00412.22 ELR19083.1 - 9.9e-09 35.3 2.9 2.1e-08 34.3 2.9 1.6 1 0 0 1 1 1 1 LIM domain Peptidase_A24 PF01478.18 ELR19084.1 - 0.042 14.2 0.5 0.052 14.0 0.5 1.2 1 0 0 1 1 1 0 Type IV leader peptidase family DUF4781 PF16013.5 ELR19084.1 - 0.079 11.8 0.4 0.11 11.2 0.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4781) Ldr_toxin PF13940.6 ELR19084.1 - 0.11 12.6 1.8 0.24 11.5 1.8 1.5 1 0 0 1 1 1 0 Toxin Ldr, type I toxin-antitoxin system LapA_dom PF06305.11 ELR19084.1 - 2.7 7.9 4.8 5.6 6.9 2.3 2.2 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain Pilin_N PF07790.11 ELR19084.1 - 2.8 8.9 7.9 6.7 7.7 6.2 2.3 2 0 0 2 2 2 0 Archaeal Type IV pilin, N-terminal IncF PF17626.2 ELR19086.1 - 0.1 13.0 0.4 0.26 11.6 0.2 1.8 2 0 0 2 2 2 0 Inclusion membrane protein F DUF179 PF02622.15 ELR19087.1 - 2.6e-13 50.2 0.0 1.1e-12 48.2 0.0 2.2 2 1 0 2 2 2 1 Uncharacterized ACR, COG1678 LRR_8 PF13855.6 ELR19087.1 - 0.00018 21.2 0.5 0.00064 19.4 0.4 1.9 1 1 1 2 2 2 1 Leucine rich repeat LRR_1 PF00560.33 ELR19087.1 - 0.0052 17.1 0.5 1.6 9.6 0.1 3.2 2 0 0 2 2 2 1 Leucine Rich Repeat RhoGEF PF00621.20 ELR19088.1 - 3.2e-40 138.3 2.9 4.3e-40 137.9 2.9 1.2 1 0 0 1 1 1 1 RhoGEF domain PTS_2-RNA PF01885.16 ELR19089.1 - 1.7e-30 106.4 0.0 2e-30 106.2 0.0 1.1 1 0 0 1 1 1 1 RNA 2'-phosphotransferase, Tpt1 / KptA family 2OG-FeII_Oxy_2 PF13532.6 ELR19090.1 - 1e-35 123.7 0.0 1.3e-35 123.4 0.0 1.2 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Utp21 PF04192.12 ELR19091.1 - 1.4e-22 80.3 0.2 1.4e-22 80.3 0.2 1.4 2 0 0 2 2 2 1 Utp21 specific WD40 associated putative domain Cnn_1N PF07989.11 ELR19091.1 - 0.0013 18.8 0.2 0.0028 17.8 0.2 1.6 1 0 0 1 1 1 1 Centrosomin N-terminal motif 1 Utp12 PF04003.12 ELR19091.1 - 0.003 17.8 0.4 0.0043 17.3 0.4 1.2 1 0 0 1 1 1 1 Dip2/Utp12 Family TMEM223 PF14640.6 ELR19093.1 - 3.4e-05 24.1 0.0 3.9e-05 23.9 0.0 1.0 1 0 0 1 1 1 1 Transmembrane protein 223 Pro_isomerase PF00160.21 ELR19094.1 - 1e-42 146.1 0.0 1.4e-42 145.7 0.0 1.1 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD R3H PF01424.22 ELR19096.1 - 1.2e-12 47.6 0.5 2.2e-12 46.8 0.1 1.6 2 0 0 2 2 2 1 R3H domain Atg14 PF10186.9 ELR19096.1 - 0.029 13.4 0.0 0.029 13.4 0.0 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Nop14 PF04147.12 ELR19097.1 - 0.00078 17.8 31.7 0.00078 17.8 31.7 1.6 2 0 0 2 2 2 1 Nop14-like family Phage_TAC_6 PF09550.10 ELR19097.1 - 0.03 14.8 0.3 6.4 7.3 0.0 2.4 2 0 0 2 2 2 0 Phage tail assembly chaperone protein, TAC G-patch PF01585.23 ELR19098.1 - 4.4e-10 39.3 2.6 1.9e-09 37.2 2.6 2.1 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.7 ELR19098.1 - 0.0012 18.9 1.3 0.0012 18.9 1.3 5.9 3 1 0 3 3 3 1 G-patch domain Cwf_Cwc_15 PF04889.12 ELR19098.1 - 0.0078 16.0 5.8 0.0078 16.0 5.8 3.0 2 1 0 2 2 2 1 Cwf15/Cwc15 cell cycle control protein Cullin PF00888.22 ELR19099.1 - 1.6e-50 172.4 6.2 1.2e-45 156.3 0.2 2.0 1 1 1 2 2 2 2 Cullin family Cullin_Nedd8 PF10557.9 ELR19099.1 - 1.8e-16 59.9 0.0 6.7e-16 58.1 0.0 2.0 2 0 0 2 2 2 1 Cullin protein neddylation domain Sec7 PF01369.20 ELR19099.1 - 0.09 12.4 0.0 0.49 10.0 0.0 2.1 2 0 0 2 2 2 0 Sec7 domain HSP20 PF00011.21 ELR19100.1 - 1.7e-06 28.1 0.0 3e-06 27.3 0.0 1.3 1 0 0 1 1 1 1 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 ELR19100.1 - 0.00047 19.6 0.0 0.00078 18.9 0.0 1.4 1 0 0 1 1 1 1 HSP20-like domain found in ArsA Auts2 PF15336.6 ELR19100.1 - 0.14 12.2 0.5 0.19 11.8 0.5 1.2 1 0 0 1 1 1 0 Autism susceptibility gene 2 protein TPT PF03151.16 ELR19101.1 - 7e-35 120.8 27.1 8.3e-35 120.5 27.1 1.0 1 0 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 ELR19101.1 - 8.3e-05 22.8 40.3 0.03 14.5 16.8 2.4 2 0 0 2 2 2 2 EamA-like transporter family SUI1 PF01253.22 ELR19102.1 - 4.8e-20 71.9 0.4 7.8e-20 71.2 0.4 1.4 1 0 0 1 1 1 1 Translation initiation factor SUI1 HSP20 PF00011.21 ELR19103.1 - 1.9e-15 56.9 0.0 2.5e-15 56.5 0.0 1.2 1 0 0 1 1 1 1 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 ELR19103.1 - 2.9e-10 39.6 0.0 4.8e-10 38.8 0.0 1.4 1 0 0 1 1 1 1 HSP20-like domain found in ArsA ADP_ribosyl_GH PF03747.14 ELR19104.1 - 2.1e-39 136.0 5.7 1.1e-30 107.4 1.9 2.1 1 1 1 2 2 2 2 ADP-ribosylglycohydrolase MFS_1 PF07690.16 ELR19106.1 - 3.1e-52 177.6 36.2 3.1e-52 177.6 36.2 2.0 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 ELR19106.1 - 1.3e-10 40.8 12.8 1.3e-10 40.8 12.8 2.1 2 1 0 2 2 2 1 Sugar (and other) transporter OATP PF03137.20 ELR19106.1 - 0.00015 20.2 2.3 0.00015 20.2 2.3 2.7 3 0 0 3 3 3 1 Organic Anion Transporter Polypeptide (OATP) family SnoaL PF07366.12 ELR19109.1 - 1.1e-22 80.1 0.1 3.8e-22 78.4 0.0 1.8 2 0 0 2 2 2 1 SnoaL-like polyketide cyclase SnoaL_2 PF12680.7 ELR19109.1 - 7.3e-13 49.0 0.1 1e-12 48.5 0.1 1.2 1 0 0 1 1 1 1 SnoaL-like domain Shadoo PF14999.6 ELR19110.1 - 0.074 13.2 6.8 0.032 14.3 4.3 1.6 2 0 0 2 2 2 0 Shadow of prion protein, neuroprotective IDO PF01231.18 ELR19110.1 - 0.85 8.3 5.0 0.3 9.8 2.3 1.5 1 1 0 1 1 1 0 Indoleamine 2,3-dioxygenase Sporozoite_P67 PF05642.11 ELR19110.1 - 4.9 5.1 8.3 7.1 4.6 8.0 1.5 1 1 0 1 1 1 0 Sporozoite P67 surface antigen DEP PF00610.21 ELR19112.1 - 1.3e-19 70.0 0.0 2.9e-19 68.9 0.0 1.6 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) PH PF00169.29 ELR19112.1 - 0.015 15.8 0.1 0.069 13.7 0.0 2.1 2 1 0 2 2 2 0 PH domain TSC22 PF01166.18 ELR19113.1 - 0.0021 18.3 1.8 0.0042 17.4 1.3 1.8 1 1 0 1 1 1 1 TSC-22/dip/bun family PcfJ PF14284.6 ELR19113.1 - 0.031 14.1 2.4 0.031 14.1 2.4 1.7 2 0 0 2 2 2 0 PcfJ-like protein Macoilin PF09726.9 ELR19113.1 - 0.089 11.3 7.7 0.11 11.0 7.7 1.1 1 0 0 1 1 1 0 Macoilin family Lipoprotein_6 PF01441.19 ELR19113.1 - 0.15 12.1 4.1 0.11 12.5 1.9 1.7 1 1 1 2 2 2 0 Lipoprotein FPP PF05911.11 ELR19113.1 - 0.15 10.2 18.6 0.23 9.6 18.6 1.2 1 0 0 1 1 1 0 Filament-like plant protein, long coiled-coil SNCAIP_SNCA_bd PF16700.5 ELR19113.1 - 0.26 11.0 5.0 0.58 9.9 0.1 3.1 3 0 0 3 3 3 0 Synphilin-1 alpha-Synuclein-binding domain ALMT PF11744.8 ELR19113.1 - 0.61 8.9 9.0 0.87 8.3 9.0 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Dynamin_N PF00350.23 ELR19114.1 - 2.3e-10 40.8 0.0 4.3e-09 36.6 0.0 2.8 3 0 0 3 3 3 1 Dynamin family MMR_HSR1 PF01926.23 ELR19114.1 - 9e-06 25.7 0.0 4.7e-05 23.4 0.0 2.2 2 0 0 2 2 2 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 ELR19114.1 - 0.0039 17.1 0.0 0.015 15.2 0.0 2.0 1 0 0 1 1 1 1 RsgA GTPase AAA_16 PF13191.6 ELR19114.1 - 0.0098 16.3 0.1 0.055 13.8 0.0 2.3 2 0 0 2 2 2 1 AAA ATPase domain DUF815 PF05673.13 ELR19114.1 - 0.014 14.5 0.0 0.036 13.2 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF815) ABC_tran PF00005.27 ELR19114.1 - 0.044 14.3 0.0 0.18 12.3 0.0 2.1 1 0 0 1 1 1 0 ABC transporter AAA_29 PF13555.6 ELR19114.1 - 0.058 13.1 0.0 0.14 11.9 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain KAP_NTPase PF07693.14 ELR19114.1 - 0.058 12.6 0.0 0.68 9.1 0.0 2.2 1 1 0 1 1 1 0 KAP family P-loop domain AAA_28 PF13521.6 ELR19114.1 - 0.14 12.4 2.2 6.6 7.0 0.0 2.9 2 0 0 2 2 2 0 AAA domain AAA_23 PF13476.6 ELR19114.1 - 2.4 8.6 0.0 2.4 8.6 0.0 3.6 3 1 1 4 4 4 0 AAA domain RhoGEF PF00621.20 ELR19115.1 - 4.1e-32 111.9 0.8 1.5e-31 110.1 0.8 2.0 1 1 0 1 1 1 1 RhoGEF domain ADIP PF11559.8 ELR19115.1 - 0.006 16.7 1.8 0.006 16.7 1.8 2.2 3 0 0 3 3 3 1 Afadin- and alpha -actinin-Binding Med10 PF09748.9 ELR19115.1 - 0.044 13.7 0.2 0.14 12.2 0.2 1.8 1 0 0 1 1 1 0 Transcription factor subunit Med10 of Mediator complex Sporozoite_P67 PF05642.11 ELR19115.1 - 0.75 7.8 4.9 2.1 6.4 0.4 2.2 1 1 1 2 2 2 0 Sporozoite P67 surface antigen PBD PF00786.28 ELR19116.1 - 8e-15 54.9 0.0 1.7e-14 53.9 0.0 1.5 1 0 0 1 1 1 1 P21-Rho-binding domain WH1 PF00568.23 ELR19116.1 - 2.8e-10 40.1 0.8 8.2e-10 38.6 0.3 1.9 1 1 1 2 2 2 1 WH1 domain Mito_fiss_reg PF05308.11 ELR19116.1 - 0.26 11.3 6.3 0.038 14.1 1.8 1.7 2 0 0 2 2 2 0 Mitochondrial fission regulator Ependymin PF00811.18 ELR19117.1 - 0.029 14.6 0.0 0.054 13.8 0.0 1.5 1 0 0 1 1 1 0 Ependymin IU_nuc_hydro PF01156.19 ELR19118.1 - 1e-63 215.8 2.7 3e-52 178.1 0.1 2.0 2 0 0 2 2 2 2 Inosine-uridine preferring nucleoside hydrolase F-box-like PF12937.7 ELR19119.1 - 2.9e-05 23.9 0.0 5.5e-05 23.0 0.0 1.4 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ELR19119.1 - 0.013 15.4 0.1 0.024 14.5 0.1 1.5 1 0 0 1 1 1 0 F-box domain Zip PF02535.22 ELR19119.1 - 0.14 11.4 0.8 4.8 6.3 0.1 2.3 2 0 0 2 2 2 0 ZIP Zinc transporter TFIIF_alpha PF05793.12 ELR19119.1 - 0.85 8.1 27.3 1.2 7.6 9.1 2.1 2 0 0 2 2 2 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Coilin_N PF15862.5 ELR19119.1 - 0.87 9.4 10.7 0.89 9.4 0.1 2.4 2 0 0 2 2 2 0 Coilin N-terminus DUF913 PF06025.12 ELR19119.1 - 1.3 7.9 2.7 7.8 5.4 0.1 2.1 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) eIF3_subunit PF08597.10 ELR19119.1 - 1.6 8.6 26.8 2.1 8.2 8.4 2.3 2 0 0 2 2 2 0 Translation initiation factor eIF3 subunit AP3D1 PF06375.11 ELR19119.1 - 1.6 8.9 23.0 3.6 7.8 8.3 2.4 2 0 0 2 2 2 0 AP-3 complex subunit delta-1 CDC45 PF02724.14 ELR19119.1 - 3.7 5.7 15.4 1 7.6 2.9 2.1 2 0 0 2 2 2 0 CDC45-like protein HEAT_2 PF13646.6 ELR19120.1 - 0.0016 18.8 0.8 2.9 8.3 0.1 4.2 3 0 0 3 3 3 3 HEAT repeats Tubulin_3 PF14881.6 ELR19121.1 - 2.4e-18 66.5 0.0 6.5e-18 65.0 0.0 1.6 2 0 0 2 2 2 1 Tubulin domain Misat_Tub_SegII PF10644.9 ELR19121.1 - 7.1e-10 39.2 0.4 2e-09 37.8 0.4 1.9 1 1 0 1 1 1 1 Misato Segment II tubulin-like domain Tubulin PF00091.25 ELR19121.1 - 1.9e-06 28.2 0.0 0.002 18.3 0.0 2.3 2 0 0 2 2 2 2 Tubulin/FtsZ family, GTPase domain U79_P34 PF03064.16 ELR19121.1 - 0.067 12.5 0.7 0.11 11.9 0.7 1.2 1 0 0 1 1 1 0 HSV U79 / HCMV P34 DUF4746 PF15928.5 ELR19121.1 - 3.7 6.9 4.4 0.6 9.5 0.8 1.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4746) DUF4632 PF15451.6 ELR19121.1 - 9 6.5 13.1 0.18 11.9 0.7 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4632) Usp PF00582.26 ELR19122.1 - 1.2e-24 87.4 2.6 1.7e-24 87.0 2.6 1.1 1 0 0 1 1 1 1 Universal stress protein family Ras PF00071.22 ELR19123.1 - 6.8e-50 168.8 0.3 1.2e-49 168.1 0.1 1.5 2 0 0 2 2 2 1 Ras family Roc PF08477.13 ELR19123.1 - 4.5e-31 107.6 0.3 1.5e-30 105.9 0.0 1.9 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR19123.1 - 1.9e-14 53.5 0.0 2.7e-14 53.0 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 ELR19123.1 - 1.8e-05 24.2 0.1 2.6e-05 23.7 0.1 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 ELR19123.1 - 3.5e-05 23.8 0.0 5.6e-05 23.2 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_16 PF13191.6 ELR19123.1 - 0.00019 21.8 0.0 0.00043 20.7 0.0 1.7 1 1 0 1 1 1 1 AAA ATPase domain TniB PF05621.11 ELR19123.1 - 0.00098 18.6 0.1 0.0042 16.5 0.0 1.9 2 0 0 2 2 2 1 Bacterial TniB protein CPT PF07931.12 ELR19123.1 - 0.0038 17.1 0.0 0.0064 16.3 0.0 1.5 1 0 0 1 1 1 1 Chloramphenicol phosphotransferase-like protein SRPRB PF09439.10 ELR19123.1 - 0.0064 15.9 0.0 0.014 14.8 0.0 1.5 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit PduV-EutP PF10662.9 ELR19123.1 - 0.096 12.4 0.0 0.51 10.1 0.0 2.0 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation FeoB_N PF02421.18 ELR19123.1 - 0.13 11.8 0.0 11 5.6 0.0 2.2 2 0 0 2 2 2 0 Ferrous iron transport protein B DUF1471 PF07338.13 ELR19123.1 - 0.31 11.1 1.4 17 5.5 0.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1471) WD40 PF00400.32 ELR19124.1 - 2.6e-36 123.0 19.6 1.3e-08 35.3 0.1 9.6 10 0 0 10 10 10 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ELR19124.1 - 2.5e-12 46.9 0.8 0.00053 20.2 0.0 4.5 2 2 3 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Nucleoporin_N PF08801.11 ELR19124.1 - 0.00022 20.1 1.0 0.025 13.3 0.1 3.3 4 0 0 4 4 4 1 Nup133 N terminal like Ge1_WD40 PF16529.5 ELR19124.1 - 0.00048 19.2 1.0 6.7 5.6 0.0 4.1 2 2 1 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ELR19124.1 - 0.0012 18.7 0.1 3.2 7.6 0.0 3.3 2 1 0 3 3 3 2 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 ELR19124.1 - 0.0019 17.0 0.6 0.0072 15.0 0.1 2.0 2 0 0 2 2 2 1 Nucleoporin Nup120/160 PD40 PF07676.12 ELR19124.1 - 0.0076 16.2 0.1 21 5.2 0.0 4.1 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat WD40_like PF17005.5 ELR19124.1 - 0.0076 15.6 0.0 2.9 7.1 0.0 2.2 2 0 0 2 2 2 2 WD40-like domain Coatomer_WDAD PF04053.14 ELR19124.1 - 0.1 11.7 0.0 0.37 9.8 0.0 2.0 2 0 0 2 2 2 0 Coatomer WD associated region PQQ_3 PF13570.6 ELR19124.1 - 0.16 12.5 1.2 23 5.6 0.0 3.8 4 0 0 4 4 4 0 PQQ-like domain DUF4402 PF14352.6 ELR19124.1 - 0.34 11.5 3.7 0.5 11.0 2.1 2.1 2 1 0 2 2 2 0 Domain of unknown function (DUF4402) F-box-like PF12937.7 ELR19125.1 - 6.1e-08 32.4 0.8 9.4e-08 31.8 0.8 1.3 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ELR19125.1 - 0.00061 19.6 0.5 0.00098 18.9 0.5 1.3 1 0 0 1 1 1 1 F-box domain Exostosin PF03016.15 ELR19126.1 - 9.6e-33 113.7 0.0 1.5e-32 113.0 0.0 1.3 1 0 0 1 1 1 1 Exostosin family CENP-N PF05238.13 ELR19127.1 - 1.7e-20 73.7 5.5 3.2e-20 72.8 0.0 2.1 1 1 1 2 2 2 1 Kinetochore protein CHL4 like SR-25 PF10500.9 ELR19127.1 - 0.0055 16.3 6.9 0.0055 16.3 6.9 1.9 2 0 0 2 2 2 1 Nuclear RNA-splicing-associated protein Mucin PF01456.17 ELR19127.1 - 0.066 13.2 6.9 0.14 12.1 6.9 1.5 1 0 0 1 1 1 0 Mucin-like glycoprotein Polyketide_cyc2 PF10604.9 ELR19128.1 - 6.4e-24 84.8 0.0 7.1e-24 84.7 0.0 1.0 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport Polyketide_cyc PF03364.20 ELR19128.1 - 0.00071 19.8 0.0 0.00085 19.5 0.0 1.3 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport START PF01852.19 ELR19128.1 - 0.049 13.0 0.0 0.063 12.7 0.0 1.3 1 0 0 1 1 1 0 START domain ubiquitin PF00240.23 ELR19129.1 - 3.1e-104 340.8 14.4 2.9e-34 116.6 0.8 3.0 3 0 0 3 3 3 3 Ubiquitin family Rad60-SLD PF11976.8 ELR19129.1 - 1.6e-50 168.8 15.0 2.3e-16 59.4 0.8 3.0 3 0 0 3 3 3 3 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 ELR19129.1 - 3e-19 69.2 6.5 8e-05 23.0 0.2 4.5 3 3 0 3 3 3 3 Ubiquitin-like domain TBK1_ULD PF18396.1 ELR19129.1 - 3.5e-12 46.1 4.3 0.011 15.6 0.1 3.2 3 0 0 3 3 3 3 TANK binding kinase 1 ubiquitin-like domain DUF2407 PF10302.9 ELR19129.1 - 3.6e-12 46.8 0.4 0.032 14.8 0.0 3.1 1 1 1 3 3 3 3 DUF2407 ubiquitin-like domain Rad60-SLD_2 PF13881.6 ELR19129.1 - 1e-11 44.9 2.1 0.04 14.0 0.1 4.0 3 3 0 3 3 3 3 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_5 PF18037.1 ELR19129.1 - 1.4e-11 44.6 5.3 0.014 15.7 0.2 3.1 1 1 2 3 3 3 3 Ubiquitin-like domain Sde2_N_Ubi PF13019.6 ELR19129.1 - 2.6e-07 30.6 0.1 0.87 9.4 0.0 3.2 1 1 2 3 3 3 3 Silencing defective 2 N-terminal ubiquitin domain Ubiquitin_4 PF18036.1 ELR19129.1 - 1.7e-06 28.0 17.2 5 7.3 0.2 6.0 6 0 0 6 6 6 3 Ubiquitin-like domain DUF3861 PF12977.7 ELR19129.1 - 5.3e-06 26.5 1.4 2.9 8.1 0.0 3.2 3 0 0 3 3 3 3 Domain of Unknown Function with PDB structure (DUF3861) Methyltrans_RNA PF04452.14 ELR19129.1 - 0.00073 18.9 0.3 1.2 8.4 0.0 2.4 2 0 0 2 2 2 2 RNA methyltransferase DUF2870 PF11069.8 ELR19129.1 - 0.0013 19.1 0.0 33 4.9 0.0 3.6 3 0 0 3 3 3 0 Protein of unknown function (DUF2870) Big_3_3 PF13750.6 ELR19129.1 - 0.002 17.8 0.0 21 4.7 0.0 3.2 3 0 0 3 3 3 0 Bacterial Ig-like domain (group 3) Raf1_HTH PF18579.1 ELR19129.1 - 0.0021 17.7 0.5 26 4.6 0.0 3.3 3 0 0 3 3 3 0 Rubisco accumulation factor 1 helix turn helix domain UDP-g_GGTase PF06427.11 ELR19129.1 - 0.0023 18.0 2.9 3.1 7.9 0.1 3.2 3 0 0 3 3 3 2 UDP-glucose:Glycoprotein Glucosyltransferase ACT_5 PF13710.6 ELR19129.1 - 0.0027 17.5 3.6 13 5.7 0.1 3.3 3 0 0 3 3 3 0 ACT domain ACT_4 PF13291.6 ELR19129.1 - 0.0041 17.7 0.5 45 4.7 0.0 3.3 3 0 0 3 3 3 0 ACT domain DUF493 PF04359.14 ELR19129.1 - 0.0061 17.1 0.1 54 4.5 0.0 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF493) DUF969 PF06149.12 ELR19129.1 - 0.0061 16.0 0.0 13 5.1 0.0 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF969) Big_7 PF17957.1 ELR19129.1 - 0.0076 17.0 0.0 64 4.4 0.0 3.1 3 0 0 3 3 3 0 Bacterial Ig domain DUF1866 PF08952.11 ELR19129.1 - 0.0078 16.1 0.3 34 4.3 0.0 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF1866) RBD PF02196.15 ELR19129.1 - 0.011 15.8 0.0 54 4.0 0.0 3.3 3 0 0 3 3 3 0 Raf-like Ras-binding domain ProRS-C_2 PF09181.10 ELR19129.1 - 0.048 13.8 3.7 41 4.4 0.1 3.2 3 0 0 3 3 3 0 Prolyl-tRNA synthetase, C-terminal Baculo_p48 PF04878.13 ELR19129.1 - 0.075 12.0 0.0 12 4.7 0.0 2.4 3 0 0 3 3 3 0 Baculovirus P48 protein ORF11CD3 PF10549.9 ELR19129.1 - 0.081 13.0 1.3 1e+02 3.1 0.0 4.7 6 0 0 6 6 6 0 ORF11CD3 domain Coagulin PF02035.15 ELR19129.1 - 0.097 12.6 2.0 59 3.5 0.0 3.1 3 0 0 3 3 3 0 Coagulin YukD PF08817.10 ELR19129.1 - 0.1 13.3 0.1 1.4e+02 3.3 0.0 3.3 3 0 0 3 3 3 0 WXG100 protein secretion system (Wss), protein YukD PI3K_p85B PF02192.16 ELR19129.1 - 0.12 12.1 7.0 21 4.9 0.2 3.3 3 0 0 3 3 3 0 PI3-kinase family, p85-binding domain Tash_PEST PF07708.11 ELR19129.1 - 0.13 12.4 18.4 4.5 7.6 1.4 3.3 3 0 0 3 3 3 0 Tash protein PEST motif Plexin_cytopl PF08337.12 ELR19129.1 - 0.17 10.5 12.9 5.8 5.5 0.6 4.3 3 2 1 4 4 4 0 Plexin cytoplasmic RasGAP domain Phage_sheath_1N PF17481.2 ELR19129.1 - 0.19 12.2 3.8 79 3.8 3.8 3.0 1 1 0 1 1 1 0 Phage tail sheath protein beta-sandwich domain DMA PF03474.14 ELR19129.1 - 0.24 11.0 1.5 72 3.1 0.0 3.3 3 0 0 3 3 3 0 DMRTA motif Myosin_N PF02736.19 ELR19129.1 - 0.41 10.5 3.4 76 3.3 0.0 3.9 3 0 0 3 3 3 0 Myosin N-terminal SH3-like domain Apc13p PF05839.11 ELR19130.1 - 2e-05 24.7 3.7 7e-05 22.9 3.7 1.7 1 1 1 2 2 2 1 Apc13p protein RRM_1 PF00076.22 ELR19131.1 - 3.4e-36 122.9 0.1 9.8e-15 54.1 0.0 3.5 3 1 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 ELR19131.1 - 2.8e-09 36.6 0.0 9.9e-06 25.2 0.0 2.9 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 ELR19131.1 - 5e-06 26.6 0.0 0.0063 16.6 0.0 3.4 3 0 0 3 3 3 1 RNA recognition motif RRM_occluded PF16842.5 ELR19131.1 - 0.0021 17.9 0.0 0.079 12.8 0.0 2.8 3 0 0 3 3 3 1 Occluded RNA-recognition motif RRM_3 PF08777.11 ELR19131.1 - 0.022 14.8 0.1 0.31 11.1 0.0 2.7 2 2 1 3 3 3 0 RNA binding motif DUF4388 PF14332.6 ELR19132.1 - 0.046 14.0 0.0 0.15 12.3 0.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4388) LRR_1 PF00560.33 ELR19133.1 - 0.18 12.5 0.5 4.9 8.1 0.3 2.5 2 1 0 2 2 2 0 Leucine Rich Repeat ADP_ribosyl_GH PF03747.14 ELR19134.1 - 1.1e-64 218.9 2.2 1.4e-64 218.6 2.2 1.1 1 0 0 1 1 1 1 ADP-ribosylglycohydrolase Ribosomal_L11 PF00298.19 ELR19137.1 - 0.015 15.8 0.0 8.4 7.0 0.0 2.4 2 0 0 2 2 2 0 Ribosomal protein L11, RNA binding domain Ribosomal_L11_N PF03946.14 ELR19137.1 - 0.021 14.7 0.0 0.036 13.9 0.0 1.3 1 0 0 1 1 1 0 Ribosomal protein L11, N-terminal domain zf-RING_2 PF13639.6 ELR19138.1 - 9.7e-14 51.4 2.6 9.7e-14 51.4 2.6 1.7 2 0 0 2 2 1 1 Ring finger domain zf-RING_11 PF17123.5 ELR19138.1 - 6.7e-09 35.3 1.2 6.7e-09 35.3 1.2 2.1 2 0 0 2 2 2 1 RING-like zinc finger zf-C3HC4_3 PF13920.6 ELR19138.1 - 1.4e-07 31.2 1.8 2.8e-07 30.3 1.8 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 ELR19138.1 - 2.2e-06 27.4 3.0 4.7e-06 26.4 3.0 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 ELR19138.1 - 2.6e-06 27.2 2.8 5.3e-06 26.2 2.8 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 ELR19138.1 - 2e-05 24.5 0.4 5.2e-05 23.2 0.4 1.7 1 0 0 1 1 1 1 RING-type zinc-finger zf-rbx1 PF12678.7 ELR19138.1 - 2.6e-05 24.4 7.6 0.00019 21.6 7.6 2.2 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_5 PF14634.6 ELR19138.1 - 0.00021 21.2 3.3 0.00042 20.2 3.3 1.5 1 0 0 1 1 1 1 zinc-RING finger domain Zn_ribbon_17 PF17120.5 ELR19138.1 - 0.0004 19.9 4.4 0.00086 18.9 4.4 1.5 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type Tetraspanin PF00335.20 ELR19138.1 - 0.0043 16.8 1.9 0.0057 16.4 1.4 1.5 1 1 0 1 1 1 1 Tetraspanin family Prok-RING_4 PF14447.6 ELR19138.1 - 0.0062 16.4 2.2 0.012 15.4 2.2 1.6 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 FANCL_C PF11793.8 ELR19138.1 - 0.02 15.0 2.8 0.02 15.0 2.8 2.0 2 0 0 2 2 2 0 FANCL C-terminal domain zf-ANAPC11 PF12861.7 ELR19138.1 - 0.042 13.9 3.8 0.18 11.9 3.8 2.1 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger FMN_red PF03358.15 ELR19138.1 - 0.057 13.2 0.1 0.17 11.6 0.2 1.8 2 0 0 2 2 2 0 NADPH-dependent FMN reductase zf-RING-like PF08746.11 ELR19138.1 - 0.06 13.7 5.1 0.13 12.6 5.1 1.6 1 0 0 1 1 1 0 RING-like domain zf-RING_4 PF14570.6 ELR19138.1 - 0.5 10.2 2.4 1.3 8.9 2.4 1.7 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain RINGv PF12906.7 ELR19138.1 - 1.2 9.3 6.5 3.7 7.8 6.5 1.8 1 1 0 1 1 1 0 RING-variant domain zf-HC5HC2H_2 PF13832.6 ELR19138.1 - 4.3 7.5 8.4 0.4 10.9 3.1 2.0 2 1 0 2 2 2 0 PHD-zinc-finger like domain zf-HC5HC2H PF13771.6 ELR19138.1 - 5.7 7.3 10.2 1.7 9.0 5.6 2.3 2 1 0 2 2 2 0 PHD-like zinc-binding domain Ank_2 PF12796.7 ELR19139.1 - 3.3e-26 91.7 10.3 2.7e-09 37.5 0.2 6.2 3 1 4 7 7 7 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ELR19139.1 - 9.2e-23 80.3 12.0 2.7e-08 34.2 0.4 7.2 7 1 1 8 8 8 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 ELR19139.1 - 2.2e-20 70.6 21.3 3.4e-06 27.0 0.0 10.2 10 0 0 10 10 10 5 Ankyrin repeat Ank PF00023.30 ELR19139.1 - 3.5e-14 52.5 29.9 1.1e-05 25.6 0.1 9.8 11 1 0 11 11 11 5 Ankyrin repeat Ank_5 PF13857.6 ELR19139.1 - 3.7e-12 46.2 22.6 0.00042 20.5 0.1 8.5 6 1 3 9 9 9 4 Ankyrin repeats (many copies) F-box-like PF12937.7 ELR19139.1 - 2.3e-09 37.0 0.1 5.7e-09 35.7 0.1 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ELR19139.1 - 6.4e-07 29.1 0.0 1.7e-06 27.7 0.0 1.7 1 0 0 1 1 1 1 F-box domain CENP-B_dimeris PF09026.10 ELR19139.1 - 0.0013 19.1 3.8 0.004 17.5 1.3 2.5 2 0 0 2 2 2 1 Centromere protein B dimerisation domain FAM176 PF14851.6 ELR19139.1 - 0.018 14.7 1.9 0.42 10.3 0.1 2.3 2 0 0 2 2 2 0 FAM176 family MarR_2 PF12802.7 ELR19139.1 - 0.038 13.9 0.2 0.67 9.9 0.0 3.3 4 0 0 4 4 4 0 MarR family Filamin PF00630.19 ELR19140.1 - 2.8e-59 198.3 1.7 3.2e-13 50.4 0.6 5.8 5 0 0 5 5 5 5 Filamin/ABP280 repeat Invasin_D3 PF09134.10 ELR19140.1 - 1.3e-13 51.1 38.5 0.00045 20.5 1.3 5.8 5 1 1 6 6 6 4 Invasin, domain 3 YtkA PF13115.6 ELR19140.1 - 0.00059 20.4 5.0 1.8 9.2 0.0 4.7 5 0 0 5 5 5 2 YtkA-like Neurexophilin PF06312.12 ELR19140.1 - 0.019 14.4 1.5 0.049 13.1 0.1 2.0 2 0 0 2 2 2 0 Neurexophilin DUF5060 PF16586.5 ELR19140.1 - 0.022 15.1 3.4 26 5.3 0.0 5.2 5 0 0 5 5 5 0 Domain of unknown function (DUF5060) DUF4366 PF14283.6 ELR19140.1 - 0.026 14.6 0.1 0.052 13.6 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4366) CopC PF04234.12 ELR19140.1 - 0.041 14.9 0.8 43 5.2 0.1 4.2 4 1 0 4 4 3 0 CopC domain Big_3_5 PF16640.5 ELR19140.1 - 0.097 12.9 53.8 0.018 15.2 6.3 5.8 4 1 0 5 5 5 0 Bacterial Ig-like domain (group 3) DUF3244 PF11589.8 ELR19140.1 - 0.12 12.4 0.8 10 6.3 0.0 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF3244) PBP_N PF17093.5 ELR19140.1 - 0.18 12.1 0.4 0.72 10.1 0.4 2.0 1 0 0 1 1 1 0 Penicillin-binding protein N-terminus Big_3 PF07523.12 ELR19140.1 - 0.22 11.8 17.8 4.5 7.6 0.4 5.8 5 2 1 6 6 5 0 Bacterial Ig-like domain (group 3) DUF756 PF05506.12 ELR19140.1 - 0.59 11.1 4.7 66 4.5 0.0 4.5 4 1 1 5 5 5 0 Domain of unknown function (DUF756) SpaA PF17802.1 ELR19140.1 - 1.4 9.3 5.8 2.5 8.5 1.1 3.5 3 1 0 3 3 3 0 Prealbumin-like fold domain 4HBT_2 PF13279.6 ELR19141.1 - 3.9e-28 98.4 0.0 6.7e-14 52.4 0.0 2.1 2 0 0 2 2 2 2 Thioesterase-like superfamily 4HBT PF03061.22 ELR19141.1 - 4e-19 68.8 0.1 8e-11 42.2 0.0 2.4 2 0 0 2 2 2 2 Thioesterase superfamily Acyl-ACP_TE PF01643.17 ELR19141.1 - 1.8e-09 37.2 0.0 0.00093 18.6 0.0 2.6 2 0 0 2 2 2 2 Acyl-ACP thioesterase Ribosomal_60s PF00428.19 ELR19141.1 - 6.8 7.4 11.1 1.7 9.3 7.1 2.0 2 0 0 2 2 2 0 60s Acidic ribosomal protein Pkinase_Tyr PF07714.17 ELR19142.1 - 4.1e-81 272.1 0.0 6.3e-81 271.5 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ELR19142.1 - 1.9e-45 155.3 0.0 3.2e-45 154.6 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain SAM_1 PF00536.30 ELR19142.1 - 1.5e-08 35.0 0.6 4e-08 33.6 0.6 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 ELR19142.1 - 1.9e-08 34.3 0.5 5.6e-08 32.8 0.5 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Ras PF00071.22 ELR19142.1 - 2.4e-06 27.2 0.0 4.5e-06 26.4 0.0 1.3 1 0 0 1 1 1 1 Ras family Kdo PF06293.14 ELR19142.1 - 0.0029 17.0 0.0 0.0063 15.9 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family WD40 PF00400.32 ELR19142.1 - 0.0051 17.6 8.1 6.4 7.8 0.3 5.0 4 0 0 4 4 4 1 WD domain, G-beta repeat Kinase-like PF14531.6 ELR19142.1 - 0.027 13.8 0.0 0.057 12.7 0.0 1.5 1 0 0 1 1 1 0 Kinase-like Pkinase_fungal PF17667.1 ELR19142.1 - 0.054 12.3 0.1 0.054 12.3 0.1 2.3 2 0 0 2 2 2 0 Fungal protein kinase APH PF01636.23 ELR19142.1 - 0.079 12.9 0.1 0.18 11.7 0.1 1.6 1 0 0 1 1 1 0 Phosphotransferase enzyme family Pkinase_Tyr PF07714.17 ELR19143.1 - 6.7e-45 153.4 0.8 1.7e-32 112.8 0.2 2.1 1 1 1 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 ELR19143.1 - 7.9e-33 113.9 0.2 5.3e-24 85.0 0.1 2.1 1 1 1 2 2 2 2 Protein kinase domain Kdo PF06293.14 ELR19143.1 - 1.8e-05 24.2 0.3 3.3e-05 23.3 0.3 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family FTA2 PF13095.6 ELR19143.1 - 0.00034 20.3 0.0 0.0022 17.7 0.0 2.0 1 1 0 1 1 1 1 Kinetochore Sim4 complex subunit FTA2 APH PF01636.23 ELR19143.1 - 0.00048 20.1 0.0 0.001 19.1 0.0 1.6 1 0 0 1 1 1 1 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 ELR19143.1 - 0.013 14.3 0.0 0.023 13.5 0.0 1.3 1 0 0 1 1 1 0 Fungal protein kinase CAP_GLY PF01302.25 ELR19143.1 - 0.03 14.4 0.1 2.2 8.3 0.0 3.2 3 0 0 3 3 3 0 CAP-Gly domain Kinase-like PF14531.6 ELR19143.1 - 0.044 13.1 0.0 0.07 12.4 0.0 1.2 1 0 0 1 1 1 0 Kinase-like Haspin_kinase PF12330.8 ELR19143.1 - 0.072 12.0 0.0 0.13 11.2 0.0 1.4 1 1 0 1 1 1 0 Haspin like kinase domain TPX2 PF06886.11 ELR19143.1 - 0.15 12.3 4.5 7.1 7.0 0.3 2.2 2 0 0 2 2 2 0 Targeting protein for Xklp2 (TPX2) Actin PF00022.19 ELR19144.1 - 2.1e-97 326.3 0.0 9.1e-97 324.2 0.0 1.7 1 1 0 1 1 1 1 Actin RasGEF PF00617.19 ELR19145.1 - 3.4e-52 177.2 0.4 5.5e-52 176.5 0.4 1.4 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 ELR19145.1 - 1.4e-12 47.8 0.0 7.1e-12 45.5 0.0 2.2 2 0 0 2 2 2 1 RasGEF N-terminal motif Mon2_C PF16206.5 ELR19146.1 - 6.5e-71 239.6 0.4 2e-58 198.2 1.9 3.2 3 0 0 3 3 3 3 C-terminal region of Mon2 protein DCB PF16213.5 ELR19146.1 - 5.8e-49 166.2 7.1 1.6e-47 161.5 7.5 2.8 2 0 0 2 2 2 1 Dimerisation and cyclophilin-binding domain of Mon2 Sec7_N PF12783.7 ELR19146.1 - 1e-37 129.5 2.0 8.2e-37 126.5 0.6 3.1 2 0 0 2 2 2 1 Guanine nucleotide exchange factor in Golgi transport N-terminal DUF1981 PF09324.10 ELR19146.1 - 4.5e-09 36.1 2.1 1e-06 28.5 0.0 4.7 5 0 0 5 5 5 1 Domain of unknown function (DUF1981) OST-HTH PF12872.7 ELR19146.1 - 0.0012 18.6 0.0 0.0044 16.8 0.0 1.9 1 0 0 1 1 1 1 OST-HTH/LOTUS domain UME PF08064.13 ELR19146.1 - 0.0018 18.2 0.1 1.2 9.1 0.0 4.8 4 0 0 4 4 4 1 UME (NUC010) domain HEAT PF02985.22 ELR19146.1 - 0.044 14.0 2.4 43 4.7 0.0 5.3 5 0 0 5 5 5 0 HEAT repeat Secretin_N_2 PF07655.13 ELR19146.1 - 0.13 12.8 0.8 0.47 11.0 0.8 1.9 1 0 0 1 1 1 0 Secretin N-terminal domain RTP1_C1 PF10363.9 ELR19146.1 - 0.33 11.1 1.6 1.9 8.7 0.1 3.1 4 0 0 4 4 4 0 Required for nuclear transport of RNA pol II C-terminus 1 BTB PF00651.31 ELR19147.1 - 8.9e-13 48.4 0.0 2.3e-12 47.1 0.0 1.7 1 0 0 1 1 1 1 BTB/POZ domain BTB PF00651.31 ELR19149.1 - 1.8e-12 47.5 0.0 4.7e-12 46.1 0.0 1.7 1 1 0 1 1 1 1 BTB/POZ domain Peptidase_C54 PF03416.19 ELR19150.1 - 1.6e-98 329.5 0.0 1.9e-98 329.3 0.0 1.0 1 0 0 1 1 1 1 Peptidase family C54 Peptidase_C78 PF07910.13 ELR19150.1 - 0.19 11.2 0.0 0.29 10.6 0.0 1.2 1 0 0 1 1 1 0 Peptidase family C78 SCAI PF12070.8 ELR19151.1 - 8e-35 120.7 3.1 1e-34 120.4 3.1 1.1 1 0 0 1 1 1 1 Protein SCAI SnoaL PF07366.12 ELR19151.1 - 6e-09 35.8 0.0 9.8e-09 35.1 0.0 1.3 1 0 0 1 1 1 1 SnoaL-like polyketide cyclase SnoaL_2 PF12680.7 ELR19151.1 - 1e-08 35.8 0.1 3.1e-08 34.2 0.0 1.8 2 1 0 2 2 2 1 SnoaL-like domain SnoaL_4 PF13577.6 ELR19151.1 - 0.00028 21.0 0.1 0.00046 20.3 0.1 1.5 1 0 0 1 1 1 1 SnoaL-like domain SnoaL_3 PF13474.6 ELR19151.1 - 0.003 17.8 0.4 0.034 14.4 0.1 2.2 1 1 1 2 2 2 1 SnoaL-like domain XRN_N PF03159.18 ELR19152.1 - 4.6e-23 81.9 0.1 5.2e-23 81.7 0.1 1.0 1 0 0 1 1 1 1 XRN 5'-3' exonuclease N-terminus DUF4595 PF15283.6 ELR19152.1 - 0.02 15.0 0.0 0.022 14.8 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4595) with porin-like fold PQ-loop PF04193.14 ELR19152.1 - 0.13 12.1 0.0 0.17 11.7 0.0 1.3 1 0 0 1 1 1 0 PQ loop repeat Adeno_E3 PF06040.11 ELR19153.1 - 0.051 13.8 0.1 0.087 13.0 0.1 1.3 1 0 0 1 1 1 0 Adenovirus E3 protein DUF3040 PF11239.8 ELR19153.1 - 0.16 12.3 2.7 0.44 10.9 0.8 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3040) EphA2_TM PF14575.6 ELR19153.1 - 1.3 9.9 3.7 9.7 7.2 2.8 2.2 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain Lactamase_B_2 PF12706.7 ELR19154.1 - 1.7e-08 34.2 0.3 1.1e-07 31.6 0.3 1.9 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B PF00753.27 ELR19154.1 - 3.7e-05 23.8 0.0 9e-05 22.6 0.0 1.6 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_3 PF13483.6 ELR19154.1 - 0.083 12.8 0.0 0.14 12.1 0.0 1.4 1 0 0 1 1 1 0 Beta-lactamase superfamily domain Rap_GAP PF02145.15 ELR19155.1 - 8.8e-57 191.7 0.0 1.4e-56 191.0 0.0 1.3 1 0 0 1 1 1 1 Rap/ran-GAP Glyco_hydro_52 PF03512.13 ELR19155.1 - 0.12 11.3 0.0 0.24 10.3 0.0 1.4 1 0 0 1 1 1 0 Glycosyl hydrolase family 52 VWA PF00092.28 ELR19156.1 - 2.6e-12 47.4 0.0 4.7e-12 46.5 0.0 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.6 ELR19156.1 - 5e-10 40.0 0.1 1.2e-09 38.7 0.1 1.7 1 0 0 1 1 1 1 von Willebrand factor type A domain vWA-TerF-like PF10138.9 ELR19156.1 - 0.0011 19.1 0.0 0.0028 17.8 0.0 1.7 1 0 0 1 1 1 1 vWA found in TerF C terminus VWA_3 PF13768.6 ELR19156.1 - 0.0044 17.0 0.1 0.011 15.7 0.1 1.7 1 0 0 1 1 1 1 von Willebrand factor type A domain Ku_N PF03731.15 ELR19156.1 - 0.16 11.7 0.2 2.7 7.7 0.0 2.2 2 0 0 2 2 2 0 Ku70/Ku80 N-terminal alpha/beta domain GRP PF07172.11 ELR19157.1 - 0.026 15.2 0.1 0.04 14.6 0.1 1.2 1 0 0 1 1 1 0 Glycine rich protein family SH3_2 PF07653.17 ELR19158.1 - 0.0017 18.0 0.0 0.005 16.5 0.0 1.9 1 0 0 1 1 1 1 Variant SH3 domain LRR_6 PF13516.6 ELR19159.1 - 8.6e-08 31.6 4.8 11 6.3 0.0 7.8 9 0 0 9 9 9 3 Leucine Rich repeat F-box-like PF12937.7 ELR19159.1 - 2.9e-05 23.9 1.8 0.00022 21.1 0.0 2.5 2 0 0 2 2 2 1 F-box-like LRR_4 PF12799.7 ELR19159.1 - 0.00026 21.3 0.2 3 8.4 0.1 4.3 4 1 1 5 5 5 2 Leucine Rich repeats (2 copies) F-box PF00646.33 ELR19159.1 - 0.0098 15.8 4.2 1.1 9.2 0.1 3.8 3 1 0 3 3 3 1 F-box domain PRANC PF09372.10 ELR19159.1 - 0.013 15.8 0.0 0.026 14.8 0.0 1.5 1 0 0 1 1 1 0 PRANC domain DUF3223 PF11523.8 ELR19160.1 - 3.5e-08 34.2 0.1 2.3e-07 31.6 0.1 2.2 2 1 0 2 2 2 1 Protein of unknown function (DUF3223) Y_phosphatase PF00102.27 ELR19161.1 - 8.3e-59 199.0 0.0 1.2e-58 198.4 0.0 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase DSPc PF00782.20 ELR19161.1 - 4.9e-06 26.4 0.0 1.2e-05 25.2 0.0 1.6 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 ELR19161.1 - 0.0041 17.1 0.0 0.0098 15.9 0.0 1.6 1 0 0 1 1 1 1 Tyrosine phosphatase family PTPlike_phytase PF14566.6 ELR19161.1 - 0.69 10.0 0.0 0.69 10.0 0.0 3.1 3 1 0 3 3 3 0 Inositol hexakisphosphate Dicty_CAR PF05462.11 ELR19162.1 - 4.4e-17 62.2 10.3 5.7e-17 61.8 10.3 1.1 1 0 0 1 1 1 1 Slime mold cyclic AMP receptor 7tm_2 PF00002.24 ELR19162.1 - 9.8e-09 34.9 16.0 1.4e-08 34.4 16.0 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) Git3 PF11710.8 ELR19162.1 - 1.2e-06 28.4 16.5 3.1e-06 27.1 16.5 1.6 1 1 0 1 1 1 1 G protein-coupled glucose receptor regulating Gpa2 GPR_Gpa2_C PF11970.8 ELR19162.1 - 2.2e-06 27.6 0.0 7.6e-06 25.9 0.0 1.9 1 0 0 1 1 1 1 G protein-coupled glucose receptor regulating Gpa2 C-term SR-25 PF10500.9 ELR19162.1 - 5.9 6.4 11.4 7.6 6.1 11.4 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Y_phosphatase2 PF03162.13 ELR19163.1 - 7.2e-62 207.8 0.0 8e-62 207.7 0.0 1.0 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase3 PF13350.6 ELR19163.1 - 3.2e-06 27.3 0.0 4.2e-06 26.9 0.0 1.3 1 0 0 1 1 1 1 Tyrosine phosphatase family DSPc PF00782.20 ELR19163.1 - 0.0014 18.4 0.1 0.002 17.9 0.1 1.4 1 1 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 ELR19163.1 - 0.0031 17.1 0.0 0.0039 16.8 0.0 1.1 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Pkinase_Tyr PF07714.17 ELR19165.1 - 3e-108 361.0 0.0 7.4e-56 189.3 0.0 2.5 2 1 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 ELR19165.1 - 6e-102 340.5 0.0 2.4e-50 171.4 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Peripla_BP_6 PF13458.6 ELR19165.1 - 1.3e-43 150.0 7.2 5.3e-20 72.4 0.1 3.6 3 0 0 3 3 3 3 Periplasmic binding protein Pkinase_fungal PF17667.1 ELR19165.1 - 4.1e-08 32.4 0.0 3.3e-05 22.8 0.0 2.2 2 0 0 2 2 2 2 Fungal protein kinase Kdo PF06293.14 ELR19165.1 - 0.00045 19.6 0.1 0.81 9.0 0.0 2.3 2 0 0 2 2 2 2 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 ELR19165.1 - 0.00045 20.2 2.4 0.13 12.2 0.1 3.4 3 1 1 4 4 4 2 Phosphotransferase enzyme family ANF_receptor PF01094.28 ELR19165.1 - 0.0015 17.7 0.0 0.74 8.8 0.0 2.2 2 0 0 2 2 2 2 Receptor family ligand binding region Kinase-like PF14531.6 ELR19165.1 - 0.0023 17.3 0.0 0.83 8.9 0.0 2.3 2 0 0 2 2 2 2 Kinase-like FAO_M PF16350.5 ELR19165.1 - 0.031 14.6 0.1 0.08 13.3 0.1 1.7 1 0 0 1 1 1 0 FAD dependent oxidoreductase central domain RIO1 PF01163.22 ELR19165.1 - 0.12 11.9 0.1 4 7.0 0.2 2.2 2 0 0 2 2 2 0 RIO1 family FAM76 PF16046.5 ELR19166.1 - 0.0025 17.2 6.5 0.0052 16.2 6.5 1.5 1 0 0 1 1 1 1 FAM76 protein IHO1 PF15771.5 ELR19166.1 - 0.003 16.4 4.3 0.003 16.4 4.3 1.4 2 0 0 2 2 2 1 Interactor of HORMAD1 protein 1 DUF812 PF05667.11 ELR19166.1 - 0.13 11.2 10.1 0.16 10.8 10.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF812) FAM176 PF14851.6 ELR19166.1 - 0.22 11.2 11.3 0.88 9.2 6.1 2.5 2 0 0 2 2 2 0 FAM176 family Atrophin-1 PF03154.15 ELR19166.1 - 0.82 7.9 8.8 1.4 7.1 8.8 1.3 1 0 0 1 1 1 0 Atrophin-1 family Kei1 PF08552.11 ELR19166.1 - 0.9 9.4 4.0 0.33 10.8 1.1 1.7 2 0 0 2 2 2 0 Inositolphosphorylceramide synthase subunit Kei1 CPSF100_C PF13299.6 ELR19166.1 - 1.5 9.0 6.7 1.5 9.0 1.9 2.3 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal Connexin PF00029.19 ELR19166.1 - 3.6 7.3 6.6 1.9 8.2 3.9 1.8 2 0 0 2 2 2 0 Connexin F-box-like PF12937.7 ELR19168.1 - 0.0043 16.9 3.4 0.0088 15.9 3.4 1.6 1 0 0 1 1 1 1 F-box-like CRISPR_Cse2 PF09485.10 ELR19168.1 - 0.014 15.9 0.1 0.024 15.1 0.1 1.5 1 0 0 1 1 1 0 CRISPR-associated protein Cse2 (CRISPR_cse2) F-box PF00646.33 ELR19168.1 - 0.03 14.2 3.0 0.03 14.2 3.0 1.9 2 0 0 2 2 2 0 F-box domain DUF4690 PF15756.5 ELR19170.1 - 0.018 15.6 0.1 0.018 15.6 0.1 1.8 2 1 0 2 2 2 0 Small Novel Rich in Cartilage CBS PF00571.28 ELR19171.1 - 4.4e-30 103.9 3.9 4.4e-10 39.8 0.0 4.3 4 0 0 4 4 4 4 CBS domain CAAD PF14159.6 ELR19171.1 - 0.043 13.7 0.0 0.11 12.4 0.0 1.6 1 0 0 1 1 1 0 CAAD domains of cyanobacterial aminoacyl-tRNA synthetase SL4P PF17618.2 ELR19171.1 - 0.051 13.6 0.0 1.3 9.1 0.0 2.8 2 1 2 4 4 4 0 Uncharacterized Strongylid L4 protein MIOX PF05153.15 ELR19172.1 - 8.7e-101 336.7 2.1 1e-100 336.5 2.1 1.0 1 0 0 1 1 1 1 Myo-inositol oxygenase Actin PF00022.19 ELR19173.1 - 5.7e-27 94.4 0.0 6.7e-19 67.8 0.0 3.3 2 1 1 3 3 3 3 Actin CcmH PF03918.14 ELR19174.1 - 0.06 12.6 0.3 0.21 10.9 0.3 2.0 1 1 0 1 1 1 0 Cytochrome C biogenesis protein SAPS PF04499.15 ELR19174.1 - 9.2 4.9 8.0 11 4.7 8.0 1.0 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Rax2 PF12768.7 ELR19175.1 - 0.11 12.0 0.1 0.24 10.8 0.1 1.6 1 0 0 1 1 1 0 Cortical protein marker for cell polarity CcmD PF04995.14 ELR19175.1 - 7.9 6.7 11.6 0.034 14.2 2.1 2.0 3 0 0 3 3 3 0 Heme exporter protein D (CcmD) SVM_signal PF12113.8 ELR19176.1 - 0.021 14.7 3.5 0.021 14.7 3.5 3.5 3 0 0 3 3 3 0 SVM protein signal sequence SAP PF02037.27 ELR19177.1 - 3e-62 205.5 33.3 6.7e-14 51.3 0.1 6.6 6 0 0 6 6 6 6 SAP domain HeH PF12949.7 ELR19177.1 - 8.7e-09 34.9 15.1 0.84 9.4 0.1 7.2 6 3 0 6 6 6 5 HeH/LEM domain HTH_27 PF13463.6 ELR19177.1 - 0.027 14.9 4.2 1.1 9.8 0.0 5.3 5 1 1 6 6 6 0 Winged helix DNA-binding domain LEM PF03020.15 ELR19177.1 - 0.37 10.4 4.4 27 4.4 0.0 4.7 5 0 0 5 5 5 0 LEM domain DUF5600 PF18150.1 ELR19177.1 - 0.38 11.3 1.5 0.84 10.2 0.1 2.3 3 0 0 3 3 3 0 Domain of unknown function (DUF5600) PASTA PF03793.19 ELR19177.1 - 0.41 10.5 4.0 17 5.3 0.0 5.4 7 0 0 7 7 7 0 PASTA domain FANC_SAP PF18081.1 ELR19177.1 - 0.55 10.4 22.5 2.2 8.5 0.4 6.9 7 0 0 7 7 7 0 Fanconi anemia-associated nuclease SAP domain DUF4119 PF13494.6 ELR19177.1 - 4.6 7.4 7.1 5.9 7.1 0.1 3.5 3 0 0 3 3 3 0 Domain of unknown function, B. Theta Gene description (DUF4119) SOG2 PF10428.9 ELR19178.1 - 3 6.9 18.0 3.5 6.7 18.0 1.0 1 0 0 1 1 1 0 RAM signalling pathway protein DUF747 PF05346.11 ELR19179.1 - 1.2e-29 103.8 1.4 1.6e-29 103.4 1.4 1.1 1 0 0 1 1 1 1 Eukaryotic membrane protein family Cullin_binding PF03556.15 ELR19180.1 - 8.5e-23 81.1 0.4 1.3e-22 80.5 0.4 1.3 1 0 0 1 1 1 1 Cullin binding Cupin_8 PF13621.6 ELR19182.1 - 1.1e-32 113.7 0.0 1.4e-32 113.4 0.0 1.1 1 0 0 1 1 1 1 Cupin-like domain Cupin_4 PF08007.12 ELR19182.1 - 7.5e-08 32.2 0.0 0.0047 16.4 0.0 2.3 2 0 0 2 2 2 2 Cupin superfamily protein PH PF00169.29 ELR19182.1 - 3.2e-05 24.4 0.0 0.00012 22.5 0.0 1.9 1 1 1 2 2 2 1 PH domain JmjC PF02373.22 ELR19182.1 - 0.00053 20.4 0.1 0.0029 18.0 0.0 2.2 3 0 0 3 3 3 1 JmjC domain, hydroxylase Cupin_2 PF07883.11 ELR19182.1 - 0.0069 16.1 0.0 0.019 14.6 0.0 1.7 1 0 0 1 1 1 1 Cupin domain VIT PF08487.10 ELR19183.1 - 2.1e-43 147.0 1.6 7.2e-43 145.3 0.1 2.6 2 0 0 2 2 2 1 Vault protein inter-alpha-trypsin domain PARP PF00644.20 ELR19183.1 - 1.2e-35 122.9 0.6 6.8e-35 120.4 0.6 2.3 1 1 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain ubiquitin PF00240.23 ELR19183.1 - 4.5e-29 100.0 0.3 1.1e-26 92.3 0.1 2.8 2 0 0 2 2 2 1 Ubiquitin family 14-3-3 PF00244.20 ELR19183.1 - 6.6e-25 87.9 2.0 6.6e-25 87.9 2.0 2.5 3 0 0 3 3 2 1 14-3-3 protein VWA_3 PF13768.6 ELR19183.1 - 3.7e-24 85.4 0.0 8.9e-24 84.2 0.0 1.7 1 0 0 1 1 1 1 von Willebrand factor type A domain PARP_reg PF02877.14 ELR19183.1 - 3.1e-13 50.0 2.2 1.2e-12 48.1 2.2 2.1 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase, regulatory domain VIT_2 PF13757.6 ELR19183.1 - 3.2e-13 49.4 0.0 7.8e-13 48.1 0.0 1.7 1 0 0 1 1 1 1 Vault protein inter-alpha-trypsin domain Rad60-SLD PF11976.8 ELR19183.1 - 1.1e-12 47.6 0.8 9.1e-12 44.6 0.4 2.4 2 0 0 2 2 2 1 Ubiquitin-2 like Rad60 SUMO-like VWA PF00092.28 ELR19183.1 - 1.5e-11 44.8 0.0 4.5e-11 43.3 0.0 1.8 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.6 ELR19183.1 - 1.2e-09 38.8 0.0 5.4e-09 36.7 0.0 2.3 1 0 0 1 1 1 1 von Willebrand factor type A domain Ribosomal_60s PF00428.19 ELR19183.1 - 4.8e-07 30.3 8.6 4.8e-07 30.3 8.6 5.5 6 1 0 6 6 3 1 60s Acidic ribosomal protein WH2 PF02205.20 ELR19183.1 - 0.00084 19.1 0.0 0.0024 17.7 0.0 1.8 1 0 0 1 1 1 1 WH2 motif DUF763 PF05559.11 ELR19183.1 - 0.0033 16.7 0.5 0.0083 15.3 0.2 1.7 1 1 0 1 1 1 1 Protein of unknown function (DUF763) Ubiquitin_2 PF14560.6 ELR19183.1 - 0.041 14.3 0.0 0.1 13.1 0.0 1.6 1 0 0 1 1 1 0 Ubiquitin-like domain BRCT PF00533.26 ELR19184.1 - 3.6e-10 40.1 0.0 9.1e-10 38.8 0.0 1.7 2 0 0 2 2 2 1 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 ELR19184.1 - 3.3e-08 33.8 0.0 8.2e-08 32.6 0.0 1.6 2 0 0 2 2 2 1 BRCT domain, a BRCA1 C-terminus domain PTCB-BRCT PF12738.7 ELR19184.1 - 8.1e-07 28.9 0.0 1.9e-06 27.7 0.0 1.6 1 0 0 1 1 1 1 twin BRCT domain RhoGEF PF00621.20 ELR19185.1 - 2.1e-37 129.2 3.1 2.1e-37 129.2 3.1 2.5 3 0 0 3 3 3 1 RhoGEF domain PH PF00169.29 ELR19185.1 - 4.9e-09 36.6 0.0 1.5e-08 35.0 0.0 1.9 1 0 0 1 1 1 1 PH domain IQ_SEC7_PH PF16453.5 ELR19185.1 - 0.019 14.9 0.1 0.075 13.0 0.1 2.0 1 0 0 1 1 1 0 PH domain DUF4806 PF16064.5 ELR19185.1 - 0.18 12.1 1.7 1.8 8.9 0.0 2.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4806) PH_13 PF16652.5 ELR19185.1 - 5.7 6.7 16.6 0.21 11.4 2.2 4.3 2 2 2 4 4 4 0 Pleckstrin homology domain PCIF1_WW PF12237.8 ELR19186.1 - 0.095 12.3 0.0 0.22 11.1 0.0 1.6 2 0 0 2 2 2 0 Phosphorylated CTD interacting factor 1 WW domain FMO-like PF00743.19 ELR19187.1 - 3.3e-83 279.9 0.1 4.1e-83 279.6 0.1 1.0 1 0 0 1 1 1 1 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 ELR19187.1 - 4.6e-23 81.9 0.0 9.8e-19 67.7 0.0 2.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 ELR19187.1 - 1.4e-11 44.2 0.0 6.2e-09 35.5 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 ELR19187.1 - 8.6e-09 35.0 0.2 2.1e-05 23.9 0.0 3.0 3 0 0 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_8 PF13450.6 ELR19187.1 - 9.4e-07 29.0 0.0 2.4e-06 27.7 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 ELR19187.1 - 3.9e-06 26.7 1.5 0.022 14.4 0.0 2.8 2 1 1 3 3 3 2 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 ELR19187.1 - 1.3e-05 25.2 0.0 0.00072 19.6 0.0 3.1 3 1 0 3 3 3 1 FAD-NAD(P)-binding Pyr_redox PF00070.27 ELR19187.1 - 2.7e-05 24.6 0.3 0.042 14.4 0.0 2.5 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 ELR19187.1 - 6.6e-05 22.4 0.1 6.6e-05 22.4 0.1 1.6 2 0 0 2 2 2 1 FAD dependent oxidoreductase Thi4 PF01946.17 ELR19187.1 - 0.00046 19.5 0.2 0.0014 17.9 0.1 1.7 2 0 0 2 2 2 1 Thi4 family FAD_binding_2 PF00890.24 ELR19187.1 - 0.00096 18.3 0.2 0.0019 17.4 0.2 1.4 1 0 0 1 1 1 1 FAD binding domain HI0933_like PF03486.14 ELR19187.1 - 0.0015 17.3 0.1 0.0047 15.7 0.2 1.7 2 0 0 2 2 2 1 HI0933-like protein IlvN PF07991.12 ELR19187.1 - 0.012 15.2 0.0 0.037 13.6 0.0 1.8 2 0 0 2 2 2 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain GIDA PF01134.22 ELR19187.1 - 0.017 14.2 0.2 0.065 12.3 0.4 1.8 2 0 0 2 2 2 0 Glucose inhibited division protein A AlaDh_PNT_C PF01262.21 ELR19187.1 - 0.04 13.2 0.5 0.077 12.3 0.5 1.4 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain 2-Hacid_dh_C PF02826.19 ELR19187.1 - 0.057 12.8 0.0 0.83 9.0 0.0 2.2 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_Gly3P_dh_N PF01210.23 ELR19187.1 - 0.16 11.9 0.0 0.27 11.2 0.0 1.4 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus 3HCDH_N PF02737.18 ELR19187.1 - 0.23 11.3 0.1 0.36 10.7 0.1 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Methyltransf_11 PF08241.12 ELR19188.1 - 4.1e-09 37.0 0.0 7.9e-09 36.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 ELR19188.1 - 1.6e-08 34.3 0.0 2.4e-08 33.7 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_25 PF13649.6 ELR19188.1 - 1.6e-08 35.1 0.0 2.9e-08 34.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 ELR19188.1 - 1.6e-06 27.8 0.0 2.9e-06 26.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain PRMT5 PF05185.16 ELR19188.1 - 4.4e-06 26.7 0.0 8e-06 25.8 0.0 1.5 1 0 0 1 1 1 1 PRMT5 arginine-N-methyltransferase Methyltransf_18 PF12847.7 ELR19188.1 - 0.00025 21.0 0.0 0.00061 19.7 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ELR19188.1 - 0.0016 19.2 0.0 0.0025 18.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 ELR19188.1 - 0.0016 18.3 0.0 0.0025 17.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 ELR19188.1 - 0.002 17.5 0.0 0.0031 16.9 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_9 PF08003.11 ELR19188.1 - 0.0022 17.0 0.0 0.0043 16.0 0.0 1.5 2 0 0 2 2 2 1 Protein of unknown function (DUF1698) Methyltransf_24 PF13578.6 ELR19188.1 - 0.0022 19.0 0.0 0.0054 17.7 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain TehB PF03848.14 ELR19188.1 - 0.0043 16.5 0.0 0.0086 15.5 0.0 1.4 1 0 0 1 1 1 1 Tellurite resistance protein TehB Methyltransf_31 PF13847.6 ELR19188.1 - 0.0062 16.3 0.0 0.0097 15.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Met_10 PF02475.16 ELR19188.1 - 0.017 14.9 0.0 0.025 14.3 0.0 1.2 1 0 0 1 1 1 0 Met-10+ like-protein Tim44 PF04280.15 ELR19189.1 - 6.1e-05 23.2 0.1 0.0004 20.5 0.0 1.9 2 0 0 2 2 2 1 Tim44-like domain Polysacc_deac_1 PF01522.21 ELR19190.1 - 1.2e-18 67.2 0.0 1.6e-18 66.8 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide deacetylase Glyco_hydro_57 PF03065.15 ELR19190.1 - 0.018 14.3 0.0 0.022 13.9 0.0 1.1 1 0 0 1 1 1 0 Glycosyl hydrolase family 57 PhoD PF09423.10 ELR19191.1 - 5.1e-12 45.5 5.9 2.3e-11 43.3 5.8 1.9 1 1 1 2 2 2 1 PhoD-like phosphatase Drc1-Sld2 PF11719.8 ELR19191.1 - 0.0043 16.7 0.3 0.0066 16.1 0.3 1.2 1 0 0 1 1 1 1 DNA replication and checkpoint protein Peptidase_M22 PF00814.25 ELR19192.1 - 2.9e-86 289.5 0.0 3.4e-86 289.3 0.0 1.0 1 0 0 1 1 1 1 Glycoprotease family BcrAD_BadFG PF01869.20 ELR19192.1 - 0.044 13.3 0.0 0.25 10.8 0.0 2.0 2 1 0 2 2 2 0 BadF/BadG/BcrA/BcrD ATPase family RRM_1 PF00076.22 ELR19193.1 - 8.1e-36 121.7 0.3 1.7e-12 47.0 0.0 3.5 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 ELR19193.1 - 7.8e-07 28.7 0.0 0.05 13.2 0.0 3.5 2 1 1 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.8 ELR19193.1 - 0.00058 19.9 0.0 0.49 10.5 0.0 2.9 2 0 0 2 2 2 2 Limkain b1 RRM_occluded PF16842.5 ELR19193.1 - 0.0071 16.2 0.0 6.4 6.7 0.0 3.2 3 0 0 3 3 3 2 Occluded RNA-recognition motif Nup35_RRM_2 PF14605.6 ELR19193.1 - 0.03 14.3 1.5 0.2 11.7 0.1 2.8 3 0 0 3 3 3 0 Nup53/35/40-type RNA recognition motif RRM_7 PF16367.5 ELR19193.1 - 0.11 12.7 0.0 1.1 9.4 0.0 2.4 2 0 0 2 2 2 0 RNA recognition motif Histone PF00125.24 ELR19194.1 - 7.1e-08 32.9 0.9 6.3e-07 29.8 0.0 2.0 1 1 1 2 2 2 1 Core histone H2A/H2B/H3/H4 SH3_9 PF14604.6 ELR19195.1 - 1.5e-16 60.0 0.2 2.6e-16 59.2 0.2 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 ELR19195.1 - 2.3e-16 59.1 0.2 4.5e-16 58.2 0.2 1.5 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 ELR19195.1 - 5.4e-16 58.0 0.1 1e-15 57.1 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain DUF812 PF05667.11 ELR19195.1 - 0.00082 18.4 2.1 0.00093 18.2 2.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF812) DUF2967 PF11179.8 ELR19195.1 - 0.11 10.5 1.3 0.16 10.1 1.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2967) HAUS-augmin3 PF14932.6 ELR19195.1 - 0.68 9.5 12.1 0.95 9.0 10.0 2.0 1 1 1 2 2 2 0 HAUS augmin-like complex subunit 3 baeRF_family12 PF18856.1 ELR19195.1 - 1.2 9.8 8.5 0.076 13.6 2.3 2.0 2 0 0 2 2 2 0 Bacterial archaeo-eukaryotic release factor family 12 Seryl_tRNA_N PF02403.22 ELR19195.1 - 2 8.7 10.1 14 6.0 0.2 2.5 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain DUF3450 PF11932.8 ELR19195.1 - 2.1 7.6 10.5 5.6 6.2 10.3 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) Syntaxin-6_N PF09177.11 ELR19195.1 - 2.2 8.9 6.6 8.8 7.0 0.1 2.7 2 1 1 3 3 3 0 Syntaxin 6, N-terminal Nop53 PF07767.11 ELR19195.1 - 4.7 6.5 12.0 0.056 12.8 4.2 1.6 2 0 0 2 2 2 0 Nop53 (60S ribosomal biogenesis) TPR_1 PF00515.28 ELR19196.1 - 1.2e-16 59.7 0.1 0.00018 21.2 0.0 4.6 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.17 ELR19196.1 - 6.7e-15 53.9 4.5 0.004 17.1 0.1 5.1 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_8 PF13181.6 ELR19196.1 - 9.8e-12 44.1 0.4 5.6e-05 23.0 0.0 4.1 4 0 0 4 4 4 2 Tetratricopeptide repeat DUF1736 PF08409.11 ELR19196.1 - 1.7e-11 43.9 0.7 4.4e-11 42.6 0.7 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF1736) TPR_12 PF13424.6 ELR19196.1 - 4.7e-11 42.8 0.1 5.4e-05 23.4 0.0 3.2 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.6 ELR19196.1 - 3e-09 37.4 0.0 5.5e-06 26.9 0.0 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_7 PF13176.6 ELR19196.1 - 4.5e-09 35.7 0.4 0.18 11.9 0.0 4.6 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_10 PF13374.6 ELR19196.1 - 9.9e-09 34.8 0.0 0.00064 19.5 0.0 3.7 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_19 PF14559.6 ELR19196.1 - 6.9e-08 32.9 0.0 0.00021 21.7 0.1 3.2 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.6 ELR19196.1 - 1.8e-06 28.3 0.0 2 9.5 0.0 4.7 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_6 PF13174.6 ELR19196.1 - 2.1e-05 24.9 0.0 13 6.7 0.1 4.6 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_11 PF13414.6 ELR19196.1 - 4e-05 23.2 0.1 0.011 15.3 0.1 3.0 3 1 0 3 3 3 1 TPR repeat TPR_3 PF07720.12 ELR19196.1 - 9.8e-05 22.3 0.2 0.01 15.8 0.0 2.8 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_17 PF13431.6 ELR19196.1 - 0.037 14.4 6.6 0.096 13.1 0.3 4.1 5 0 0 5 5 4 0 Tetratricopeptide repeat BTAD PF03704.17 ELR19196.1 - 0.069 13.6 0.1 0.37 11.2 0.0 1.9 2 0 0 2 2 2 0 Bacterial transcriptional activator domain TPR_9 PF13371.6 ELR19196.1 - 0.089 13.0 0.0 4.3 7.5 0.0 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat tRNA_m1G_MT PF01746.21 ELR19197.1 - 5.2e-33 114.4 0.1 5.2e-33 114.4 0.1 2.0 2 0 0 2 2 2 1 tRNA (Guanine-1)-methyltransferase DUF3677 PF12432.8 ELR19197.1 - 0.028 14.7 0.0 0.083 13.2 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3677) NAM-associated PF14303.6 ELR19197.1 - 2.7 8.7 18.7 4.1 8.1 18.7 1.2 1 0 0 1 1 1 0 No apical meristem-associated C-terminal domain MOSC PF03473.17 ELR19198.1 - 4.7e-14 52.5 0.0 8.2e-14 51.7 0.0 1.4 1 0 0 1 1 1 1 MOSC domain TFIIB PF00382.19 ELR19198.1 - 4.6e-09 36.2 0.0 8.6e-09 35.3 0.0 1.4 1 0 0 1 1 1 1 Transcription factor TFIIB repeat TF_Zn_Ribbon PF08271.12 ELR19198.1 - 3.1e-06 26.6 0.9 5.5e-06 25.8 0.9 1.4 1 0 0 1 1 1 1 TFIIB zinc-binding F-box-like PF12937.7 ELR19198.1 - 2.2e-05 24.2 0.0 2.2e-05 24.2 0.0 1.8 2 0 0 2 2 2 1 F-box-like RB_B PF01857.20 ELR19198.1 - 0.034 14.2 0.0 0.18 11.8 0.0 1.9 2 0 0 2 2 2 0 Retinoblastoma-associated protein B domain F-box PF00646.33 ELR19198.1 - 0.48 10.4 2.3 3.2 7.7 2.3 2.2 1 1 0 1 1 1 0 F-box domain GvpD PF07088.11 ELR19199.1 - 0.078 11.6 0.0 0.12 11.0 0.0 1.1 1 0 0 1 1 1 0 GvpD gas vesicle protein TFIIB PF00382.19 ELR19200.1 - 1.2e-09 38.1 0.0 1.6e-09 37.7 0.0 1.3 1 0 0 1 1 1 1 Transcription factor TFIIB repeat RB_B PF01857.20 ELR19200.1 - 0.0048 16.9 0.0 0.0055 16.7 0.0 1.1 1 0 0 1 1 1 1 Retinoblastoma-associated protein B domain TFIIB PF00382.19 ELR19201.1 - 1.9e-22 79.1 0.0 7e-13 48.4 0.0 2.6 2 0 0 2 2 2 2 Transcription factor TFIIB repeat MOSC_N PF03476.16 ELR19201.1 - 3e-20 72.3 0.0 5.1e-20 71.5 0.0 1.4 1 0 0 1 1 1 1 MOSC N-terminal beta barrel domain Aminotran_5 PF00266.19 ELR19201.1 - 3.3e-18 65.8 0.0 5.9e-18 65.0 0.0 1.4 1 1 0 1 1 1 1 Aminotransferase class-V RB_B PF01857.20 ELR19201.1 - 0.068 13.2 0.1 0.12 12.4 0.1 1.3 1 0 0 1 1 1 0 Retinoblastoma-associated protein B domain Polyketide_cyc PF03364.20 ELR19202.1 - 0.079 13.2 0.0 0.14 12.4 0.0 1.4 1 0 0 1 1 1 0 Polyketide cyclase / dehydrase and lipid transport Aminotran_5 PF00266.19 ELR19203.1 - 1.4e-25 90.0 0.0 2.6e-25 89.2 0.0 1.4 1 0 0 1 1 1 1 Aminotransferase class-V MOSC PF03473.17 ELR19203.1 - 4.3e-23 81.8 0.0 1e-22 80.5 0.0 1.7 1 0 0 1 1 1 1 MOSC domain MOSC_N PF03476.16 ELR19203.1 - 6.1e-23 81.0 0.0 1.4e-22 79.8 0.0 1.6 1 0 0 1 1 1 1 MOSC N-terminal beta barrel domain LRR_4 PF12799.7 ELR19203.1 - 8.5e-08 32.4 22.0 0.13 12.7 0.1 7.8 8 1 0 8 8 8 3 Leucine Rich repeats (2 copies) F-box-like PF12937.7 ELR19203.1 - 2.5e-05 24.1 0.0 0.0001 22.1 0.0 2.1 1 0 0 1 1 1 1 F-box-like Kinesin PF00225.23 ELR19204.1 - 9.8e-114 379.7 0.1 9.8e-114 379.7 0.1 1.8 2 0 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 ELR19204.1 - 9.3e-26 90.6 0.0 3.9e-25 88.5 0.0 2.1 2 0 0 2 2 2 1 Microtubule binding Zot PF05707.12 ELR19204.1 - 0.035 13.7 1.8 17 5.0 0.0 3.5 2 1 0 2 2 2 0 Zonular occludens toxin (Zot) DUF3605 PF12239.8 ELR19205.1 - 1.7e-23 83.6 0.0 1.3e-21 77.6 0.0 2.1 1 1 0 1 1 1 1 Protein of unknown function (DUF3605) TAL_FSA PF00923.19 ELR19206.1 - 5.5e-92 308.2 0.0 6.3e-92 308.0 0.0 1.0 1 0 0 1 1 1 1 Transaldolase/Fructose-6-phosphate aldolase Homeodomain PF00046.29 ELR19207.1 - 1.2e-11 44.3 4.2 3.1e-10 39.7 4.2 2.4 1 1 0 1 1 1 1 Homeodomain Yae1_N PF09811.9 ELR19207.1 - 0.0087 15.7 18.6 0.31 10.8 6.5 2.4 2 0 0 2 2 2 2 Essential protein Yae1, N terminal DUF4662 PF15578.6 ELR19207.1 - 6.5 6.5 8.1 4.5 7.0 6.4 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4662) TRAM_LAG1_CLN8 PF03798.16 ELR19208.1 - 1.8e-10 40.9 27.6 1.8e-10 40.9 27.6 1.5 2 0 0 2 2 2 1 TLC domain 60KD_IMP PF02096.20 ELR19208.1 - 8.8 6.2 12.3 43 4.0 12.3 2.2 1 1 0 1 1 1 0 60Kd inner membrane protein PRMT5_TIM PF17285.2 ELR19209.1 - 2.4e-69 233.4 0.0 3.4e-69 232.9 0.0 1.1 1 0 0 1 1 1 1 PRMT5 TIM barrel domain PRMT5 PF05185.16 ELR19209.1 - 6.9e-67 224.6 0.0 9.8e-67 224.1 0.0 1.2 1 0 0 1 1 1 1 PRMT5 arginine-N-methyltransferase PRMT5_C PF17286.2 ELR19209.1 - 1.6e-24 86.7 0.1 2.7e-24 86.0 0.1 1.3 1 0 0 1 1 1 1 PRMT5 oligomerisation domain Methyltransf_25 PF13649.6 ELR19209.1 - 0.00034 21.3 0.0 0.00087 20.0 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ELR19209.1 - 0.00047 20.0 0.0 0.001 18.9 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain Met_10 PF02475.16 ELR19209.1 - 0.028 14.2 0.0 0.044 13.5 0.0 1.2 1 0 0 1 1 1 0 Met-10+ like-protein PALP PF00291.25 ELR19209.1 - 0.032 13.6 0.0 0.049 13.0 0.0 1.2 1 0 0 1 1 1 0 Pyridoxal-phosphate dependent enzyme Methyltransf_28 PF02636.17 ELR19209.1 - 0.12 12.0 0.0 0.25 10.9 0.0 1.5 1 0 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase IF-2B PF01008.17 ELR19209.1 - 0.19 10.9 0.0 0.3 10.2 0.0 1.3 1 0 0 1 1 1 0 Initiation factor 2 subunit family RVT_1 PF00078.27 ELR19210.1 - 8.3e-08 32.0 0.1 1e-07 31.7 0.1 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Pox_A6 PF04924.12 ELR19210.1 - 0.11 11.5 0.0 0.14 11.1 0.0 1.1 1 0 0 1 1 1 0 Poxvirus A6 protein Ubiq_cyt_C_chap PF03981.12 ELR19211.1 - 2.4e-15 56.9 0.1 4.1e-15 56.1 0.1 1.3 1 0 0 1 1 1 1 Ubiquinol-cytochrome C chaperone NIF PF03031.18 ELR19212.1 - 4.8e-12 45.9 0.0 5.6e-12 45.7 0.0 1.0 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase HAD PF12710.7 ELR19212.1 - 0.036 14.5 0.0 0.047 14.1 0.0 1.2 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase DUF3343 PF11823.8 ELR19212.1 - 0.17 11.4 0.0 0.31 10.5 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3343) Aa_trans PF01490.18 ELR19214.1 - 1.6e-08 33.7 22.5 3.3e-08 32.7 22.5 1.4 1 1 0 1 1 1 1 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.13 ELR19214.1 - 0.00066 18.8 5.4 0.00066 18.8 5.4 2.5 2 1 1 3 3 3 1 Tryptophan/tyrosine permease family DUF5367 PF17329.2 ELR19214.1 - 2.3 8.4 9.5 0.1 12.7 1.6 2.9 3 0 0 3 3 3 0 Family of unknown function (DUF5367) Pkinase_Tyr PF07714.17 ELR19215.1 - 2.5e-129 430.1 0.0 1e-64 218.3 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 ELR19215.1 - 1.1e-112 375.8 0.0 1.2e-55 188.8 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain PBP_like_2 PF12849.7 ELR19215.1 - 4.4e-24 85.6 10.3 4.9e-15 55.9 6.6 2.8 2 1 0 2 2 2 2 PBP superfamily domain Guanylate_cyc PF00211.20 ELR19215.1 - 2.1e-09 37.3 0.0 5.3e-09 35.9 0.0 1.7 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain APH PF01636.23 ELR19215.1 - 2.5e-07 30.9 0.7 0.00026 21.0 0.0 3.2 2 1 1 3 3 3 2 Phosphotransferase enzyme family Haspin_kinase PF12330.8 ELR19215.1 - 4.3e-05 22.6 0.6 0.031 13.2 0.0 3.9 4 1 0 4 4 4 1 Haspin like kinase domain Pkinase_fungal PF17667.1 ELR19215.1 - 0.00081 18.3 0.0 0.78 8.4 0.0 2.3 2 0 0 2 2 2 2 Fungal protein kinase Kinase-like PF14531.6 ELR19215.1 - 0.0014 18.0 0.0 0.084 12.2 0.0 2.3 2 0 0 2 2 2 1 Kinase-like FTA2 PF13095.6 ELR19215.1 - 0.0021 17.7 0.0 0.58 9.7 0.0 3.7 2 2 1 4 4 4 1 Kinetochore Sim4 complex subunit FTA2 Kdo PF06293.14 ELR19215.1 - 0.0024 17.3 0.7 0.79 9.0 0.2 2.3 2 0 0 2 2 2 2 Lipopolysaccharide kinase (Kdo/WaaP) family Seadorna_VP7 PF07387.11 ELR19215.1 - 0.14 11.2 0.1 0.35 9.9 0.0 1.6 2 0 0 2 2 2 0 Seadornavirus VP7 EGF_2 PF07974.13 ELR19215.1 - 0.86 10.0 10.0 1.7 9.1 10.0 1.5 1 0 0 1 1 1 0 EGF-like domain Ribosomal_S5 PF00333.20 ELR19216.1 - 7.6e-16 57.9 0.0 1.4e-15 57.0 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein S5, N-terminal domain Ribosomal_S5_C PF03719.15 ELR19216.1 - 5.8e-05 22.5 0.0 0.00011 21.6 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein S5, C-terminal domain MAGE PF01454.19 ELR19217.1 - 2.7e-34 118.7 1.3 4.9e-34 117.9 0.0 2.0 3 0 0 3 3 3 1 MAGE family DTHCT PF08070.11 ELR19217.1 - 4.2 8.2 15.9 3 8.6 6.8 2.4 2 0 0 2 2 2 0 DTHCT (NUC029) region DSPc PF00782.20 ELR19218.1 - 2.4e-21 75.9 0.0 1.2e-18 67.2 0.0 2.2 2 0 0 2 2 2 2 Dual specificity phosphatase, catalytic domain DUF5427 PF10310.9 ELR19218.1 - 0.044 12.8 2.6 0.053 12.5 2.6 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5427) SWIRM-assoc_2 PF16496.5 ELR19218.1 - 0.098 11.5 1.3 0.12 11.2 1.3 1.1 1 0 0 1 1 1 0 SWIRM-associated domain at the N-terminal Init_tRNA_PT PF04179.12 ELR19218.1 - 0.16 12.3 0.0 0.82 10.0 0.0 2.0 1 1 0 1 1 1 0 Rit1 DUSP-like domain THRAP3_BCLAF1 PF15440.6 ELR19218.1 - 0.46 9.4 12.5 0.61 9.0 12.5 1.1 1 0 0 1 1 1 0 THRAP3/BCLAF1 family SR-25 PF10500.9 ELR19218.1 - 0.51 9.9 10.8 0.73 9.4 10.8 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein DNA_pol_phi PF04931.13 ELR19218.1 - 6.2 4.8 6.2 8 4.4 6.2 1.0 1 0 0 1 1 1 0 DNA polymerase phi Methyltransf_11 PF08241.12 ELR19219.1 - 1.9e-14 54.1 0.0 3e-14 53.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ELR19219.1 - 1.9e-14 54.1 0.0 3.1e-14 53.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ELR19219.1 - 3.3e-11 43.2 0.0 4.3e-11 42.8 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ELR19219.1 - 1.7e-06 28.7 0.0 2.6e-06 28.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 ELR19219.1 - 0.00087 19.2 0.0 0.0021 17.9 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 ELR19219.1 - 0.074 12.4 0.0 0.12 11.7 0.0 1.2 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family Methyltransf_29 PF03141.16 ELR19219.1 - 0.25 9.9 0.0 0.5 8.9 0.0 1.5 1 1 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase CH PF00307.31 ELR19220.1 - 2.2e-20 72.8 0.1 7.7e-11 42.2 0.0 2.6 2 0 0 2 2 2 2 Calponin homology (CH) domain LIM PF00412.22 ELR19220.1 - 1.2e-11 44.7 5.8 2.9e-11 43.4 5.8 1.7 1 0 0 1 1 1 1 LIM domain zf-RRN7 PF11781.8 ELR19220.1 - 0.022 14.4 2.0 3.8 7.3 0.0 2.5 2 0 0 2 2 2 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 Autophagy_N PF03986.13 ELR19221.1 - 1e-17 64.4 0.1 1.7e-17 63.6 0.1 1.4 1 1 0 1 1 1 1 Autophagocytosis associated protein (Atg3), N-terminal domain Autophagy_C PF10381.9 ELR19221.1 - 1.1e-15 56.8 2.4 2e-15 56.0 2.4 1.4 1 0 0 1 1 1 1 Autophagocytosis associated protein C-terminal Autophagy_act_C PF03987.15 ELR19221.1 - 4.9e-13 49.4 0.2 8.5e-13 48.7 0.2 1.3 1 0 0 1 1 1 1 Autophagocytosis associated protein, active-site domain DSBA PF01323.20 ELR19222.1 - 5.4e-25 88.3 0.0 1.1e-24 87.3 0.0 1.4 1 1 0 1 1 1 1 DSBA-like thioredoxin domain RSN1_7TM PF02714.15 ELR19224.1 - 1.1e-52 179.1 21.8 1.1e-52 179.1 21.8 2.0 2 0 0 2 2 2 1 Calcium-dependent channel, 7TM region, putative phosphate RSN1_TM PF13967.6 ELR19224.1 - 2.2e-33 115.2 0.0 1.5e-32 112.5 0.0 2.6 1 0 0 1 1 1 1 Late exocytosis, associated with Golgi transport PHM7_cyt PF14703.6 ELR19224.1 - 3e-24 86.2 0.0 4.1e-24 85.8 0.0 1.2 1 0 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter DSPc PF00782.20 ELR19225.1 - 3.2e-21 75.5 0.0 3.8e-21 75.3 0.0 1.1 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Init_tRNA_PT PF04179.12 ELR19225.1 - 4.6e-05 23.7 0.1 7.4e-05 23.0 0.1 1.3 1 0 0 1 1 1 1 Rit1 DUSP-like domain CDKN3 PF05706.12 ELR19225.1 - 0.00028 20.6 0.0 0.00039 20.1 0.0 1.2 1 0 0 1 1 1 1 Cyclin-dependent kinase inhibitor 3 (CDKN3) PTPlike_phytase PF14566.6 ELR19225.1 - 0.0005 20.2 0.0 0.00071 19.7 0.0 1.3 1 0 0 1 1 1 1 Inositol hexakisphosphate Y_phosphatase2 PF03162.13 ELR19225.1 - 0.0017 17.9 0.0 0.0026 17.4 0.0 1.2 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase PF00102.27 ELR19225.1 - 0.006 16.2 0.0 0.0081 15.8 0.0 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.6 ELR19225.1 - 0.019 14.9 0.0 0.022 14.8 0.0 1.2 1 0 0 1 1 1 0 Tyrosine phosphatase family Mito_carr PF00153.27 ELR19226.1 - 4.5e-13 48.9 0.0 4.8e-06 26.4 0.0 2.8 3 0 0 3 3 3 2 Mitochondrial carrier protein DRMBL PF07522.14 ELR19228.1 - 7.6e-19 67.9 0.0 1.4e-18 67.1 0.0 1.5 1 0 0 1 1 1 1 DNA repair metallo-beta-lactamase RMMBL PF07521.12 ELR19228.1 - 0.1 12.6 0.0 0.2 11.6 0.0 1.5 1 0 0 1 1 1 0 Zn-dependent metallo-hydrolase RNA specificity domain BUD22 PF09073.10 ELR19228.1 - 0.35 10.1 10.6 0.53 9.6 10.6 1.4 1 0 0 1 1 1 0 BUD22 CobT PF06213.12 ELR19228.1 - 0.42 10.0 10.4 0.76 9.1 10.4 1.3 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT SDA1 PF05285.12 ELR19228.1 - 0.55 9.6 10.7 0.83 9.0 10.7 1.2 1 0 0 1 1 1 0 SDA1 Nop14 PF04147.12 ELR19228.1 - 1.3 7.2 11.5 1.7 6.7 11.5 1.1 1 0 0 1 1 1 0 Nop14-like family GATase PF00117.28 ELR19230.1 - 5.7e-14 52.3 0.0 7.4e-14 52.0 0.0 1.2 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.13 ELR19230.1 - 1.1e-07 31.8 0.0 1.5e-07 31.4 0.0 1.2 1 0 0 1 1 1 1 Peptidase C26 TFIIA_gamma_N PF02268.16 ELR19230.1 - 0.15 12.1 0.0 0.48 10.5 0.0 1.9 1 1 1 2 2 2 0 Transcription initiation factor IIA, gamma subunit, helical domain Proteasome PF00227.26 ELR19231.1 - 5.9e-34 117.2 0.0 6.6e-34 117.1 0.0 1.0 1 0 0 1 1 1 1 Proteasome subunit SMK-1 PF04802.15 ELR19232.1 - 1.6e-66 223.8 8.1 1.6e-66 223.8 8.1 2.1 2 0 0 2 2 2 1 Component of IIS longevity pathway SMK-1 CID_GANP PF16766.5 ELR19232.1 - 0.028 14.6 0.0 0.09 13.0 0.0 2.0 1 0 0 1 1 1 0 Binding region of GANP to ENY2 Lin-8 PF03353.15 ELR19232.1 - 7.6 6.0 14.0 17 4.8 14.0 1.7 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Pkinase PF00069.25 ELR19234.1 - 3.9e-65 219.8 0.7 7.4e-65 218.9 0.0 1.8 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR19234.1 - 2.8e-46 157.9 0.1 7.6e-46 156.5 0.0 1.7 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 ELR19234.1 - 2.5e-05 23.3 2.9 0.0011 17.9 0.0 2.4 2 0 0 2 2 2 1 Fungal protein kinase APH PF01636.23 ELR19234.1 - 8.7e-05 22.5 0.1 0.059 13.3 0.1 2.5 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.14 ELR19234.1 - 0.0013 18.1 1.0 0.0038 16.6 0.0 2.0 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family PCEMA1 PF07418.11 ELR19234.1 - 2.2 7.7 16.7 3.6 7.0 16.7 1.2 1 0 0 1 1 1 0 Acidic phosphoprotein precursor PCEMA1 Polyketide_cyc2 PF10604.9 ELR19235.1 - 0.08 13.2 0.0 0.11 12.8 0.0 1.2 1 0 0 1 1 1 0 Polyketide cyclase / dehydrase and lipid transport COPI_C PF06957.11 ELR19236.1 - 5.9e-09 35.2 0.3 5.9e-09 35.2 0.3 2.9 3 0 0 3 3 3 1 Coatomer (COPI) alpha subunit C-terminus SelP_N PF04592.14 ELR19236.1 - 4.4 6.7 19.0 7.8 5.8 19.0 1.3 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Zip PF02535.22 ELR19236.1 - 9.1 5.4 15.4 15 4.7 15.4 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter BSD PF03909.17 ELR19237.1 - 2.3e-10 40.3 0.1 5.8e-10 39.0 0.1 1.6 1 0 0 1 1 1 1 BSD domain Myosin_head PF00063.21 ELR19238.1 - 2.3e-235 783.0 2.7 3.8e-235 782.2 2.7 1.4 1 0 0 1 1 1 1 Myosin head (motor domain) MyTH4 PF00784.17 ELR19238.1 - 8.1e-53 177.5 0.1 1.4e-27 96.3 0.0 3.2 3 0 0 3 3 3 2 MyTH4 domain FERM_M PF00373.18 ELR19238.1 - 1.8e-28 99.3 0.0 1.3e-15 57.8 0.0 3.1 2 0 0 2 2 2 2 FERM central domain SH3_2 PF07653.17 ELR19238.1 - 4.7e-12 45.4 0.0 1.2e-10 40.9 0.0 2.5 2 0 0 2 2 2 1 Variant SH3 domain SH3_9 PF14604.6 ELR19238.1 - 5.3e-09 35.8 0.1 1.4e-08 34.4 0.0 1.8 2 0 0 2 2 2 1 Variant SH3 domain SH3_1 PF00018.28 ELR19238.1 - 6.5e-09 35.3 0.0 1.5e-08 34.1 0.0 1.7 1 0 0 1 1 1 1 SH3 domain IQ PF00612.27 ELR19238.1 - 9.2e-06 25.0 14.7 0.0012 18.4 2.7 3.1 3 0 0 3 3 3 2 IQ calmodulin-binding motif AAA_16 PF13191.6 ELR19238.1 - 0.0012 19.2 0.3 0.011 16.1 0.0 2.5 2 0 0 2 2 2 1 AAA ATPase domain RA PF00788.23 ELR19238.1 - 0.0029 18.2 0.0 0.051 14.2 0.0 2.6 2 0 0 2 2 2 1 Ras association (RalGDS/AF-6) domain AAA_22 PF13401.6 ELR19238.1 - 0.0068 16.7 0.0 0.029 14.6 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.6 ELR19238.1 - 0.02 15.2 0.1 7.3 6.9 0.0 3.5 4 0 0 4 4 4 0 AAA domain RsgA_GTPase PF03193.16 ELR19238.1 - 0.12 12.3 0.0 0.85 9.5 0.0 2.3 3 0 0 3 3 2 0 RsgA GTPase Zeta_toxin PF06414.12 ELR19238.1 - 0.67 9.2 0.0 0.67 9.2 0.0 2.8 3 0 0 3 3 3 0 Zeta toxin CH PF00307.31 ELR19239.1 - 3.6e-35 120.5 0.0 3e-16 59.6 0.0 2.9 2 0 0 2 2 2 2 Calponin homology (CH) domain LRR_6 PF13516.6 ELR19239.1 - 3e-18 64.2 9.7 0.0059 16.6 0.1 8.4 8 0 0 8 8 8 5 Leucine Rich repeat PH PF00169.29 ELR19239.1 - 3e-11 43.8 0.0 6.7e-11 42.6 0.0 1.5 1 0 0 1 1 1 1 PH domain LRR_4 PF12799.7 ELR19239.1 - 2.4e-05 24.6 13.8 0.6 10.6 1.2 6.0 2 1 7 9 9 9 6 Leucine Rich repeats (2 copies) PH_11 PF15413.6 ELR19239.1 - 0.00032 21.1 2.6 0.00032 21.1 2.6 3.0 3 1 0 3 3 3 1 Pleckstrin homology domain CAMSAP_CH PF11971.8 ELR19239.1 - 0.0007 19.4 0.0 0.049 13.5 0.0 2.8 2 1 0 2 2 2 1 CAMSAP CH domain LRR_8 PF13855.6 ELR19239.1 - 0.001 18.8 18.5 0.14 11.9 0.7 6.4 3 2 1 4 4 4 2 Leucine rich repeat PDDEXK_6 PF04720.12 ELR19239.1 - 1.5 8.7 14.8 0.51 10.3 7.6 2.3 2 0 0 2 2 2 0 PDDEXK-like family of unknown function Ribosomal_L3 PF00297.22 ELR19240.1 - 5.5e-174 578.4 6.5 6.3e-174 578.2 6.5 1.0 1 0 0 1 1 1 1 Ribosomal protein L3 PCRF PF03462.18 ELR19242.1 - 2.7e-54 184.0 4.5 3.9e-54 183.5 4.5 1.2 1 0 0 1 1 1 1 PCRF domain RF-1 PF00472.20 ELR19242.1 - 8.8e-22 77.2 8.4 1.5e-10 41.0 1.8 2.9 2 1 1 3 3 3 2 RF-1 domain OmpH PF03938.14 ELR19242.1 - 0.17 12.2 4.4 0.35 11.2 4.4 1.5 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) DUF4515 PF14988.6 ELR19242.1 - 0.17 11.7 11.0 0.34 10.7 11.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4515) BshC PF10079.9 ELR19242.1 - 0.21 10.3 3.9 0.38 9.4 3.9 1.4 1 0 0 1 1 1 0 Bacillithiol biosynthesis BshC MCC-bdg_PDZ PF10506.9 ELR19242.1 - 0.41 10.7 3.6 2.5 8.2 0.0 2.6 2 0 0 2 2 2 0 PDZ domain of MCC-2 bdg protein for Usher syndrome DUF848 PF05852.11 ELR19242.1 - 0.53 10.4 5.0 0.8 9.8 3.9 1.7 1 1 1 2 2 2 0 Gammaherpesvirus protein of unknown function (DUF848) DUF4140 PF13600.6 ELR19242.1 - 4.2 7.9 8.2 1.6 9.2 0.4 2.8 2 1 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) Homeodomain PF00046.29 ELR19243.1 - 8.4e-18 64.0 1.6 1.6e-17 63.1 1.6 1.5 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 ELR19243.1 - 2.7e-05 24.0 0.1 5.7e-05 22.9 0.1 1.6 1 0 0 1 1 1 1 Homeobox KN domain G_glu_transpept PF01019.21 ELR19244.1 - 3.4e-147 491.3 0.0 3.9e-147 491.1 0.0 1.0 1 0 0 1 1 1 1 Gamma-glutamyltranspeptidase SHNi-TPR PF10516.9 ELR19245.1 - 2.7e-05 23.5 0.1 2.7e-05 23.5 0.1 2.3 3 0 0 3 3 3 1 SHNi-TPR TPR_12 PF13424.6 ELR19245.1 - 0.00039 20.7 5.4 0.00039 20.7 5.4 2.3 1 1 0 2 2 2 1 Tetratricopeptide repeat SNAP PF14938.6 ELR19245.1 - 0.0062 16.0 7.7 0.23 10.9 0.7 2.3 2 0 0 2 2 2 2 Soluble NSF attachment protein, SNAP TPR_1 PF00515.28 ELR19245.1 - 0.095 12.6 1.5 2.6 8.0 0.1 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat Prefoldin_2 PF01920.20 ELR19245.1 - 0.19 11.7 1.8 30 4.6 0.0 2.8 2 1 0 2 2 2 0 Prefoldin subunit TPR_2 PF07719.17 ELR19245.1 - 0.87 9.9 8.5 1.5 9.1 0.3 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_7 PF13176.6 ELR19245.1 - 0.98 9.6 7.0 0.58 10.3 0.4 3.5 3 1 1 4 4 4 0 Tetratricopeptide repeat Spc7 PF08317.11 ELR19245.1 - 1.2 7.9 7.5 1.4 7.7 6.5 1.5 1 1 0 1 1 1 0 Spc7 kinetochore protein TPR_8 PF13181.6 ELR19245.1 - 3.3 8.2 4.7 11 6.5 0.1 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat adh_short_C2 PF13561.6 ELR19247.1 - 1e-59 201.9 0.0 2.8e-54 184.2 0.0 2.0 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 ELR19247.1 - 1.8e-46 158.1 0.0 2.1e-36 125.2 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase DUF1776 PF08643.10 ELR19247.1 - 0.0037 16.7 0.0 0.0056 16.1 0.0 1.2 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) KNOX2 PF03791.13 ELR19249.1 - 0.093 12.3 1.8 5.7 6.5 0.1 2.4 2 0 0 2 2 2 0 KNOX2 domain GNVR PF13807.6 ELR19249.1 - 0.14 12.1 0.3 0.26 11.2 0.3 1.4 1 0 0 1 1 1 0 G-rich domain on putative tyrosine kinase DUF5344 PF17279.2 ELR19249.1 - 0.56 10.8 4.6 6.6 7.4 0.7 2.7 3 0 0 3 3 3 0 Family of unknown function (DUF5344) TT_ORF2 PF02957.15 ELR19249.1 - 0.86 10.5 9.8 1.6 9.7 9.8 1.4 1 0 0 1 1 1 0 TT viral ORF2 Alpha-L-AF_C PF06964.12 ELR19251.1 - 0.15 12.2 0.0 0.23 11.6 0.0 1.3 1 0 0 1 1 1 0 Alpha-L-arabinofuranosidase C-terminal domain ParA PF10609.9 ELR19252.1 - 3.2e-95 318.2 0.2 3.9e-95 318.0 0.2 1.1 1 0 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase CbiA PF01656.23 ELR19252.1 - 5.9e-16 58.7 0.0 8.7e-16 58.1 0.0 1.2 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain Fer4_NifH PF00142.18 ELR19252.1 - 2.5e-10 40.2 0.0 0.00015 21.4 0.0 2.2 2 0 0 2 2 2 2 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family AAA_31 PF13614.6 ELR19252.1 - 4.3e-10 39.8 0.6 1.2e-08 35.1 0.6 2.1 1 1 1 2 2 2 1 AAA domain ArsA_ATPase PF02374.15 ELR19252.1 - 2.1e-08 33.7 0.4 5.1e-06 25.9 0.1 2.9 2 1 1 3 3 3 1 Anion-transporting ATPase MipZ PF09140.11 ELR19252.1 - 2.9e-07 30.1 0.0 5.3e-07 29.2 0.0 1.5 1 1 0 1 1 1 1 ATPase MipZ VirC1 PF07015.11 ELR19252.1 - 0.00091 18.6 0.1 0.0027 17.0 0.0 1.7 2 0 0 2 2 2 1 VirC1 protein AAA_33 PF13671.6 ELR19252.1 - 0.0048 17.1 0.0 0.097 12.8 0.0 2.2 1 1 1 2 2 2 1 AAA domain CBP_BcsQ PF06564.12 ELR19252.1 - 0.0049 16.4 0.0 0.018 14.5 0.0 1.8 2 0 0 2 2 2 1 Cellulose biosynthesis protein BcsQ CLP1_P PF16575.5 ELR19252.1 - 0.0055 16.5 0.1 0.0087 15.9 0.1 1.4 1 1 0 1 1 1 1 mRNA cleavage and polyadenylation factor CLP1 P-loop DUF1610 PF07754.11 ELR19252.1 - 0.0095 15.9 0.2 0.021 14.7 0.2 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF1610) AAA_25 PF13481.6 ELR19252.1 - 0.012 15.2 1.1 0.025 14.2 1.1 1.6 1 1 0 1 1 1 0 AAA domain Zeta_toxin PF06414.12 ELR19252.1 - 0.024 13.9 0.0 0.055 12.7 0.0 1.5 1 0 0 1 1 1 0 Zeta toxin MeaB PF03308.16 ELR19252.1 - 0.031 13.3 0.2 0.061 12.3 0.2 1.4 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_26 PF13500.6 ELR19252.1 - 0.031 14.1 0.1 13 5.6 0.0 2.7 2 1 1 3 3 3 0 AAA domain APS_kinase PF01583.20 ELR19252.1 - 0.063 13.2 0.0 0.11 12.4 0.0 1.4 1 0 0 1 1 1 0 Adenylylsulphate kinase SRP54 PF00448.22 ELR19252.1 - 0.075 12.7 0.0 0.14 11.8 0.0 1.4 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain zf_C2H2_10 PF18414.1 ELR19252.1 - 0.14 11.7 0.3 0.28 10.8 0.3 1.4 1 0 0 1 1 1 0 C2H2 type zinc-finger AAA_30 PF13604.6 ELR19252.1 - 0.15 11.7 0.4 0.44 10.2 0.3 1.8 2 0 0 2 2 2 0 AAA domain Glycos_transf_3 PF00591.21 ELR19252.1 - 0.19 11.3 0.7 0.34 10.4 0.7 1.4 1 0 0 1 1 1 0 Glycosyl transferase family, a/b domain CDC27 PF09507.10 ELR19253.1 - 8.6e-25 88.0 109.1 1.6e-13 50.9 0.0 3.4 2 1 2 4 4 4 3 DNA polymerase subunit Cdc27 BUD22 PF09073.10 ELR19254.1 - 1.3 8.3 46.8 2.3 7.5 38.4 2.3 2 0 0 2 2 2 0 BUD22 SET PF00856.28 ELR19255.1 - 3.2e-15 56.9 0.0 3.6e-14 53.5 0.0 2.4 1 1 0 1 1 1 1 SET domain TPR_12 PF13424.6 ELR19255.1 - 8.4e-08 32.4 3.2 1.7e-06 28.2 0.7 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_2 PF07719.17 ELR19255.1 - 2.9e-07 30.1 2.0 0.23 11.7 0.1 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_1 PF00515.28 ELR19255.1 - 3.2e-06 26.7 3.8 0.1 12.5 0.1 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_11 PF13414.6 ELR19255.1 - 0.0004 20.0 0.3 0.0039 16.8 0.0 2.3 2 0 0 2 2 2 1 TPR repeat TPR_16 PF13432.6 ELR19255.1 - 0.0005 20.7 1.4 0.083 13.6 0.1 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_8 PF13181.6 ELR19255.1 - 0.0015 18.6 3.5 0.85 10.0 0.1 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat ANAPC3 PF12895.7 ELR19255.1 - 0.018 15.2 0.5 0.067 13.4 0.5 2.0 1 1 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 3 RPN7 PF10602.9 ELR19255.1 - 0.029 14.1 0.2 0.078 12.7 0.1 1.8 2 0 0 2 2 2 0 26S proteasome subunit RPN7 TPR_19 PF14559.6 ELR19255.1 - 0.03 14.8 2.4 0.53 10.8 0.2 2.5 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_21 PF09976.9 ELR19255.1 - 0.056 13.2 1.8 0.23 11.2 1.8 1.9 1 1 0 1 1 1 0 Tetratricopeptide repeat-like domain TPR_14 PF13428.6 ELR19255.1 - 0.069 14.0 3.7 28 5.9 0.3 3.6 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_6 PF13174.6 ELR19255.1 - 0.19 12.4 3.1 14 6.6 0.1 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_9 PF13371.6 ELR19255.1 - 0.58 10.3 2.9 1.6 8.9 0.8 2.4 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_MalT PF17874.1 ELR19255.1 - 0.67 9.3 4.1 0.31 10.4 0.8 2.0 3 0 0 3 3 3 0 MalT-like TPR region Ecl1 PF12855.7 ELR19255.1 - 3 9.0 18.8 1.3 10.2 0.1 2.7 3 0 0 3 3 3 0 ECL1/2/3 zinc binding proteins FSA_C PF10479.9 ELR19255.1 - 4.7 5.2 12.6 7.1 4.6 12.6 1.2 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus adh_short PF00106.25 ELR19256.1 - 8e-36 123.3 5.5 6e-20 71.5 0.9 2.1 1 1 1 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 ELR19256.1 - 9.1e-20 71.2 4.1 4.7e-10 39.4 0.1 2.1 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ELR19256.1 - 1.2e-05 25.4 3.0 0.00015 21.8 0.7 2.2 2 0 0 2 2 2 1 KR domain DUF1776 PF08643.10 ELR19256.1 - 0.008 15.6 0.0 0.015 14.7 0.0 1.4 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) SP_C-Propep PF08999.10 ELR19256.1 - 0.23 11.3 5.6 0.62 9.9 5.6 1.7 1 0 0 1 1 1 0 Surfactant protein C, N terminal propeptide Cation_ATPase_C PF00689.21 ELR19256.1 - 4.2 7.0 9.7 2.7 7.7 0.7 2.3 2 0 0 2 2 2 0 Cation transporting ATPase, C-terminus ECSCR PF15820.5 ELR19256.1 - 7.9 6.4 8.6 21 5.0 8.6 1.7 1 0 0 1 1 1 0 Endothelial cell-specific chemotaxis regulator polyprenyl_synt PF00348.17 ELR19258.1 - 8.1e-63 211.9 0.0 9.8e-63 211.6 0.0 1.1 1 0 0 1 1 1 1 Polyprenyl synthetase FERM_f0 PF16511.5 ELR19260.1 - 9.9e-15 54.6 0.0 5.5e-06 26.6 0.0 4.7 4 0 0 4 4 4 3 N-terminal or F0 domain of Talin-head FERM PH PF00169.29 ELR19260.1 - 3.1e-13 50.1 1.8 6.3e-07 29.9 0.2 3.2 3 0 0 3 3 3 2 PH domain PH_11 PF15413.6 ELR19260.1 - 2.5e-07 31.1 2.0 0.0023 18.3 0.3 3.3 2 0 0 2 2 2 2 Pleckstrin homology domain FERM_N PF09379.10 ELR19260.1 - 4.4e-05 23.4 0.1 0.51 10.3 0.0 3.5 4 0 0 4 4 4 2 FERM N-terminal domain PH_3 PF14593.6 ELR19260.1 - 0.0042 17.2 0.5 2 8.6 0.1 2.7 2 0 0 2 2 2 2 PH domain FERM_N_2 PF18038.1 ELR19260.1 - 0.11 13.4 0.1 1 10.2 0.0 2.7 2 0 0 2 2 2 0 FERM N-terminal domain Alpha_adaptinC2 PF02883.20 ELR19260.1 - 0.25 11.6 0.4 0.58 10.5 0.4 1.5 1 0 0 1 1 1 0 Adaptin C-terminal domain PH_2 PF08458.10 ELR19260.1 - 0.53 10.7 0.0 0.53 10.7 0.0 2.9 3 0 0 3 3 3 0 Plant pleckstrin homology-like region PH_13 PF16652.5 ELR19260.1 - 7.9 6.3 14.1 0.043 13.6 0.6 2.7 1 1 1 2 2 2 0 Pleckstrin homology domain COesterase PF00135.28 ELR19261.1 - 5e-14 52.1 0.0 6.9e-06 25.2 0.0 2.1 2 0 0 2 2 2 2 Carboxylesterase family Abhydrolase_3 PF07859.13 ELR19261.1 - 5.8e-14 52.5 0.9 7.2e-13 48.9 0.9 2.4 1 1 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 ELR19261.1 - 4e-07 29.7 0.2 1.8e-06 27.6 0.0 2.1 2 1 0 2 2 2 1 Prolyl oligopeptidase family Abhydrolase_6 PF12697.7 ELR19261.1 - 1.2e-05 26.1 1.7 1.9e-05 25.4 1.7 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Chlorophyllase2 PF12740.7 ELR19261.1 - 1.5e-05 24.1 0.0 2.5e-05 23.3 0.0 1.3 1 0 0 1 1 1 1 Chlorophyllase enzyme PAF-AH_p_II PF03403.13 ELR19261.1 - 0.00047 18.8 0.0 0.0007 18.2 0.0 1.3 1 0 0 1 1 1 1 Platelet-activating factor acetylhydrolase, isoform II Abhydrolase_5 PF12695.7 ELR19261.1 - 0.0034 17.2 0.1 0.0059 16.4 0.1 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Say1_Mug180 PF10340.9 ELR19261.1 - 0.0051 15.7 0.0 0.0077 15.1 0.0 1.2 1 0 0 1 1 1 1 Steryl acetyl hydrolase Chlorophyllase PF07224.11 ELR19261.1 - 0.011 14.8 0.3 0.045 12.8 0.3 1.8 1 1 0 1 1 1 0 Chlorophyllase Hydrolase_4 PF12146.8 ELR19261.1 - 0.011 15.0 0.4 0.17 11.1 1.0 2.4 2 1 0 2 2 2 0 Serine aminopeptidase, S33 Lipase_3 PF01764.25 ELR19261.1 - 0.047 13.6 0.0 0.075 12.9 0.0 1.3 1 0 0 1 1 1 0 Lipase (class 3) Abhydrolase_1 PF00561.20 ELR19261.1 - 0.067 12.8 0.3 0.56 9.8 0.0 2.1 2 0 0 2 2 2 0 alpha/beta hydrolase fold Vsr PF03852.15 ELR19261.1 - 0.073 12.9 0.6 7.3 6.5 0.0 2.8 3 0 0 3 3 3 0 DNA mismatch endonuclease Vsr RasGEF PF00617.19 ELR19264.1 - 3.1e-54 183.8 0.1 2.3e-53 181.0 0.0 2.3 2 0 0 2 2 2 1 RasGEF domain RasGEF_N PF00618.20 ELR19264.1 - 1.7e-17 63.6 0.1 7.2e-17 61.6 0.0 2.2 2 0 0 2 2 2 1 RasGEF N-terminal motif GldM_N PF12081.8 ELR19264.1 - 0.14 12.3 1.7 0.55 10.3 0.3 2.6 2 1 0 2 2 2 0 GldM N-terminal domain Spatacsin_C PF14649.6 ELR19264.1 - 0.82 8.7 8.9 4.4 6.3 0.0 3.7 4 0 0 4 4 4 0 Spatacsin C-terminus SR-25 PF10500.9 ELR19264.1 - 2.7 7.5 9.4 7.5 6.1 9.4 1.7 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Esterase PF00756.20 ELR19265.1 - 6.8e-70 235.6 0.0 7.8e-70 235.4 0.0 1.0 1 0 0 1 1 1 1 Putative esterase Esterase_phd PF10503.9 ELR19265.1 - 6.4e-06 25.8 0.1 5.9e-05 22.7 0.1 2.0 1 1 0 1 1 1 1 Esterase PHB depolymerase Chlorophyllase2 PF12740.7 ELR19265.1 - 0.00014 20.9 0.0 0.00024 20.1 0.0 1.3 1 0 0 1 1 1 1 Chlorophyllase enzyme Hydrolase_4 PF12146.8 ELR19265.1 - 0.00034 20.0 0.1 0.0014 17.9 0.0 1.8 1 1 1 2 2 2 1 Serine aminopeptidase, S33 Peptidase_S9 PF00326.21 ELR19265.1 - 0.00036 20.1 0.0 0.00051 19.6 0.0 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family Lipase_3 PF01764.25 ELR19265.1 - 0.015 15.2 0.0 0.026 14.4 0.0 1.4 1 0 0 1 1 1 0 Lipase (class 3) Abhydrolase_6 PF12697.7 ELR19265.1 - 0.021 15.4 0.3 0.035 14.7 0.3 1.5 1 1 0 1 1 1 0 Alpha/beta hydrolase family AXE1 PF05448.12 ELR19265.1 - 0.021 13.5 0.0 0.028 13.1 0.0 1.3 1 0 0 1 1 1 0 Acetyl xylan esterase (AXE1) Abhydrolase_3 PF07859.13 ELR19265.1 - 0.026 14.4 0.0 0.05 13.5 0.0 1.6 1 1 0 1 1 1 0 alpha/beta hydrolase fold Chlorophyllase PF07224.11 ELR19265.1 - 0.03 13.3 0.0 0.073 12.1 0.0 1.5 2 0 0 2 2 2 0 Chlorophyllase Abhydrolase_2 PF02230.16 ELR19265.1 - 0.031 14.1 0.0 0.057 13.2 0.0 1.4 1 0 0 1 1 1 0 Phospholipase/Carboxylesterase Peptidase_S15 PF02129.18 ELR19265.1 - 0.052 13.1 0.0 1.3 8.5 0.0 2.4 1 1 1 2 2 2 0 X-Pro dipeptidyl-peptidase (S15 family) PGAP1 PF07819.13 ELR19265.1 - 0.12 12.1 0.0 0.16 11.7 0.0 1.3 1 0 0 1 1 1 0 PGAP1-like protein DLH PF01738.18 ELR19265.1 - 0.15 11.6 0.4 0.43 10.1 0.4 1.9 1 1 0 1 1 1 0 Dienelactone hydrolase family EMP24_GP25L PF01105.24 ELR19266.1 - 4.7e-44 150.5 0.0 5.8e-44 150.2 0.0 1.1 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD RED_N PF07808.13 ELR19267.1 - 3.9e-58 196.8 5.3 3.9e-58 196.8 5.3 2.7 2 0 0 2 2 2 1 RED-like protein N-terminal region RED_C PF07807.11 ELR19267.1 - 1.4e-27 96.4 3.5 1.4e-27 96.4 3.5 3.4 5 0 0 5 5 5 1 RED-like protein C-terminal region YbaB_DNA_bd PF02575.16 ELR19268.1 - 1.9e-06 28.0 1.0 2.6e-06 27.6 0.5 1.4 1 1 0 1 1 1 1 YbaB/EbfC DNA-binding family ABC_membrane_2 PF06472.15 ELR19269.1 - 4.4e-75 252.6 1.3 7.1e-75 251.9 1.3 1.3 1 0 0 1 1 1 1 ABC transporter transmembrane region 2 ABC_tran PF00005.27 ELR19269.1 - 5.2e-22 78.8 0.0 9.6e-22 78.0 0.0 1.5 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 ELR19269.1 - 0.00025 20.6 0.0 0.14 11.6 0.0 2.2 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 ELR19269.1 - 0.00026 21.6 0.0 0.00053 20.5 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_21 PF13304.6 ELR19269.1 - 0.00061 19.7 0.0 0.0013 18.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 ELR19269.1 - 0.0049 16.6 0.0 0.012 15.3 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_16 PF13191.6 ELR19269.1 - 0.076 13.4 0.0 0.31 11.4 0.0 2.0 2 0 0 2 2 2 0 AAA ATPase domain AAA_13 PF13166.6 ELR19269.1 - 0.14 10.8 0.0 0.21 10.2 0.0 1.2 1 0 0 1 1 1 0 AAA domain Rhodanese PF00581.20 ELR19270.1 - 4.6e-22 78.6 0.0 2e-10 41.1 0.0 2.3 2 0 0 2 2 2 2 Rhodanese-like domain PTE PF02126.18 ELR19270.1 - 0.21 11.0 0.0 0.33 10.3 0.0 1.2 1 0 0 1 1 1 0 Phosphotriesterase family RhoGAP PF00620.27 ELR19271.1 - 9.7e-29 100.2 0.0 2.6e-28 98.8 0.0 1.7 2 0 0 2 2 2 1 RhoGAP domain RPEL PF02755.15 ELR19271.1 - 0.02 14.6 0.0 0.072 12.8 0.0 2.0 1 0 0 1 1 1 0 RPEL repeat FERM_f0 PF16511.5 ELR19271.1 - 0.082 13.2 0.1 30 5.0 0.0 3.6 3 0 0 3 3 3 0 N-terminal or F0 domain of Talin-head FERM Ras PF00071.22 ELR19272.1 - 1e-51 174.8 0.0 1.2e-51 174.6 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR19272.1 - 1.8e-32 112.1 0.0 2.6e-32 111.6 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR19272.1 - 1.6e-13 50.4 0.0 2e-13 50.2 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 ELR19272.1 - 4.3e-05 23.5 0.0 0.14 12.1 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 ELR19272.1 - 4.4e-05 23.5 0.0 0.00014 21.9 0.0 1.7 1 1 1 2 2 2 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 ELR19272.1 - 0.00017 21.2 0.0 0.11 12.0 0.0 2.4 1 1 1 2 2 2 2 Elongation factor Tu GTP binding domain ATP_bind_1 PF03029.17 ELR19272.1 - 0.00042 20.2 0.1 0.032 14.0 0.0 2.1 1 1 0 2 2 2 1 Conserved hypothetical ATP binding protein Gtr1_RagA PF04670.12 ELR19272.1 - 0.0019 17.6 0.0 0.0023 17.3 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region PduV-EutP PF10662.9 ELR19272.1 - 0.0045 16.7 0.0 0.77 9.5 0.0 2.2 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation SRPRB PF09439.10 ELR19272.1 - 0.0067 15.9 0.0 0.013 15.0 0.0 1.5 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit AAA_7 PF12775.7 ELR19272.1 - 0.01 15.4 0.0 0.017 14.7 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_16 PF13191.6 ELR19272.1 - 0.01 16.2 0.0 0.018 15.4 0.0 1.6 1 1 0 1 1 1 0 AAA ATPase domain NACHT PF05729.12 ELR19272.1 - 0.012 15.5 0.0 0.022 14.7 0.0 1.3 1 0 0 1 1 1 0 NACHT domain cobW PF02492.19 ELR19272.1 - 0.029 13.9 0.0 0.89 9.1 0.0 2.2 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain FeoB_N PF02421.18 ELR19272.1 - 0.035 13.6 0.0 2.6 7.6 0.0 2.3 3 0 0 3 3 3 0 Ferrous iron transport protein B TniB PF05621.11 ELR19272.1 - 0.053 12.9 0.1 0.12 11.7 0.0 1.6 2 0 0 2 2 2 0 Bacterial TniB protein AAA_22 PF13401.6 ELR19272.1 - 0.087 13.1 0.0 0.24 11.7 0.0 1.8 1 1 0 1 1 1 0 AAA domain NTPase_1 PF03266.15 ELR19272.1 - 0.096 12.6 0.0 0.15 12.0 0.0 1.3 1 0 0 1 1 1 0 NTPase ATPase_2 PF01637.18 ELR19272.1 - 0.1 12.5 0.0 0.16 11.8 0.0 1.2 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea Septin PF00735.18 ELR19272.1 - 0.11 11.8 0.1 0.21 10.8 0.0 1.5 2 0 0 2 2 2 0 Septin ATPase PF06745.13 ELR19272.1 - 0.15 11.4 0.0 0.21 10.9 0.0 1.2 1 0 0 1 1 1 0 KaiC MMR_HSR1_Xtn PF16897.5 ELR19272.1 - 0.15 12.1 0.0 0.46 10.5 0.0 1.7 2 0 0 2 2 2 0 C-terminal region of MMR_HSR1 domain Rap1_C PF11626.8 ELR19273.1 - 0.075 13.1 0.0 0.081 13.0 0.0 1.2 1 0 0 1 1 1 0 TRF2-interacting telomeric protein/Rap1 - C terminal domain DUF3430 PF11912.8 ELR19275.1 - 0.03 14.4 6.5 0.039 14.0 6.5 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3430) zf-C2H2 PF00096.26 ELR19277.1 - 0.003 17.9 0.1 0.013 15.9 0.1 2.2 1 0 0 1 1 1 1 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 ELR19277.1 - 0.021 15.6 0.2 0.021 15.6 0.2 2.4 2 0 0 2 2 2 0 C2H2-type zinc finger Cyt-b5 PF00173.28 ELR19278.1 - 1.9e-10 40.7 0.0 3.2e-10 40.0 0.0 1.4 1 1 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain CrgA PF06781.12 ELR19278.1 - 0.085 12.9 0.2 0.22 11.6 0.0 1.8 2 0 0 2 2 2 0 Cell division protein CrgA SFTA2 PF15210.6 ELR19278.1 - 0.18 11.7 0.0 0.33 10.9 0.0 1.3 1 0 0 1 1 1 0 Surfactant-associated protein 2 Acetyltransf_1 PF00583.25 ELR19279.1 - 4e-09 36.7 0.2 5.6e-09 36.3 0.2 1.3 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 ELR19279.1 - 1.1e-07 32.1 0.1 1.9e-07 31.4 0.1 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 ELR19279.1 - 8.3e-07 29.0 0.0 1.4e-06 28.3 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 ELR19279.1 - 0.047 13.6 0.0 0.085 12.8 0.0 1.4 1 0 0 1 1 1 0 FR47-like protein AAA PF00004.29 ELR19280.1 - 3.9e-93 308.8 0.0 3.9e-45 153.5 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 ELR19280.1 - 3.8e-26 90.6 5.4 2.3e-14 52.9 0.0 3.0 3 0 0 3 3 3 2 AAA+ lid domain RuvB_N PF05496.12 ELR19280.1 - 1e-13 51.3 0.0 2e-06 27.6 0.0 3.2 2 1 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 ELR19280.1 - 9.4e-13 48.9 0.0 7.3e-06 26.5 0.0 3.6 2 1 1 3 3 3 2 AAA ATPase domain AAA_5 PF07728.14 ELR19280.1 - 7.8e-11 42.1 0.1 0.00014 21.9 0.1 3.5 2 2 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 ELR19280.1 - 3.6e-08 33.7 0.0 0.0034 17.5 0.0 2.5 2 0 0 2 2 2 2 AAA domain (Cdc48 subfamily) TIP49 PF06068.13 ELR19280.1 - 9.2e-08 31.7 0.0 0.0058 15.9 0.0 2.2 2 0 0 2 2 2 2 TIP49 P-loop domain AAA_33 PF13671.6 ELR19280.1 - 9.9e-08 32.3 0.0 0.00079 19.6 0.0 2.7 2 1 0 2 2 2 2 AAA domain AAA_22 PF13401.6 ELR19280.1 - 2.2e-06 28.0 0.7 0.028 14.7 0.1 4.0 2 2 2 4 4 4 1 AAA domain Mg_chelatase PF01078.21 ELR19280.1 - 1.7e-05 24.3 0.3 0.099 12.0 0.0 2.6 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI RNA_helicase PF00910.22 ELR19280.1 - 2.5e-05 24.6 0.0 0.44 10.9 0.0 2.8 3 0 0 3 3 2 2 RNA helicase Rad17 PF03215.15 ELR19280.1 - 3.6e-05 23.8 0.0 0.015 15.2 0.0 2.5 2 0 0 2 2 2 1 Rad17 P-loop domain IstB_IS21 PF01695.17 ELR19280.1 - 4.2e-05 23.4 0.0 0.14 11.9 0.0 2.7 3 0 0 3 3 2 2 IstB-like ATP binding protein AAA_14 PF13173.6 ELR19280.1 - 7.2e-05 22.8 0.0 0.059 13.4 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_28 PF13521.6 ELR19280.1 - 0.00012 22.4 0.0 0.099 12.9 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_25 PF13481.6 ELR19280.1 - 0.00015 21.4 3.7 3.2 7.3 0.0 4.0 3 1 0 3 3 3 1 AAA domain AAA_18 PF13238.6 ELR19280.1 - 0.00018 22.0 0.0 0.039 14.5 0.0 2.4 2 0 0 2 2 2 1 AAA domain ATPase PF06745.13 ELR19280.1 - 0.00069 19.0 0.0 1.5 8.1 0.0 2.5 3 0 0 3 3 3 2 KaiC TsaE PF02367.17 ELR19280.1 - 0.0011 19.0 0.0 0.39 10.7 0.0 2.5 2 1 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_7 PF12775.7 ELR19280.1 - 0.0023 17.5 0.1 1.1 8.8 0.0 2.9 3 0 0 3 3 2 1 P-loop containing dynein motor region AAA_3 PF07726.11 ELR19280.1 - 0.003 17.4 0.0 2.9 7.8 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 ELR19280.1 - 0.0036 17.0 0.0 0.78 9.4 0.0 3.2 3 1 0 3 3 2 1 Sigma-54 interaction domain Sigma54_activ_2 PF14532.6 ELR19280.1 - 0.0046 17.1 0.0 3.2 7.9 0.0 2.6 2 0 0 2 2 2 1 Sigma-54 interaction domain ATPase_2 PF01637.18 ELR19280.1 - 0.0068 16.3 0.0 0.22 11.4 0.0 2.5 2 1 1 3 3 3 1 ATPase domain predominantly from Archaea AAA_24 PF13479.6 ELR19280.1 - 0.0088 15.8 0.0 0.35 10.6 0.0 2.4 2 0 0 2 2 2 1 AAA domain IPT PF01745.16 ELR19280.1 - 0.012 15.0 0.1 4.9 6.5 0.0 3.5 4 0 0 4 4 4 0 Isopentenyl transferase ATP-synt_ab PF00006.25 ELR19280.1 - 0.041 13.5 0.5 0.39 10.3 0.2 2.4 2 1 0 2 2 1 0 ATP synthase alpha/beta family, nucleotide-binding domain Parvo_NS1 PF01057.17 ELR19280.1 - 0.043 12.9 0.0 2.3 7.3 0.0 2.2 2 0 0 2 2 2 0 Parvovirus non-structural protein NS1 Zeta_toxin PF06414.12 ELR19280.1 - 0.056 12.7 0.1 3.5 6.9 0.0 2.7 3 0 0 3 3 2 0 Zeta toxin AAA_11 PF13086.6 ELR19280.1 - 0.066 13.0 0.0 2.1 8.0 0.0 2.2 2 0 0 2 2 2 0 AAA domain PhoH PF02562.16 ELR19280.1 - 0.13 11.7 0.5 2.6 7.4 0.0 2.5 3 0 0 3 3 2 0 PhoH-like protein AAA_17 PF13207.6 ELR19280.1 - 0.16 12.4 0.0 3.9 7.9 0.0 2.4 2 0 0 2 2 2 0 AAA domain SKI PF01202.22 ELR19280.1 - 0.17 12.0 0.0 2.6 8.2 0.0 2.2 2 0 0 2 2 2 0 Shikimate kinase Cys_Met_Meta_PP PF01053.20 ELR19281.1 - 1.1e-125 419.2 0.0 1.5e-125 418.7 0.0 1.1 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_5 PF00266.19 ELR19281.1 - 3.5e-12 46.0 0.0 6.2e-12 45.1 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class-V Aminotran_1_2 PF00155.21 ELR19281.1 - 7.2e-11 41.9 0.0 1.2e-10 41.2 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class I and II Met_gamma_lyase PF06838.11 ELR19281.1 - 0.00022 19.9 0.0 0.00033 19.3 0.0 1.2 1 0 0 1 1 1 1 Methionine gamma-lyase SL4P PF17618.2 ELR19281.1 - 0.22 11.6 0.0 0.41 10.7 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized Strongylid L4 protein RasGEF PF00617.19 ELR19282.1 - 4.2e-46 157.4 3.3 7.8e-46 156.5 3.3 1.5 1 0 0 1 1 1 1 RasGEF domain SAM_2 PF07647.17 ELR19282.1 - 2.2e-10 40.5 0.1 8.9e-10 38.5 0.0 2.1 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 ELR19282.1 - 7.1e-10 39.2 0.8 4e-09 36.8 0.0 2.7 3 0 0 3 3 3 1 SAM domain (Sterile alpha motif) RasGEF_N PF00618.20 ELR19282.1 - 0.00024 21.3 0.4 0.0068 16.6 0.0 3.3 2 1 0 2 2 2 1 RasGEF N-terminal motif SR-25 PF10500.9 ELR19282.1 - 0.00096 18.8 8.6 0.0019 17.9 8.6 1.4 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein DUF240 PF03086.14 ELR19282.1 - 0.051 13.5 1.3 4.1 7.4 0.1 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF240) Pneumo_att_G PF05539.11 ELR19282.1 - 3.6 7.1 12.6 5.9 6.4 12.6 1.2 1 0 0 1 1 1 0 Pneumovirinae attachment membrane glycoprotein G Jnk-SapK_ap_N PF09744.9 ELR19282.1 - 7 6.9 8.0 4.8 7.4 0.8 3.1 2 1 0 2 2 2 0 JNK_SAPK-associated protein-1 PAS_9 PF13426.7 ELR19283.1 - 2.1e-14 53.6 0.0 1.9e-07 31.3 0.0 3.5 2 1 0 2 2 2 2 PAS domain SAM_2 PF07647.17 ELR19283.1 - 1.3e-07 31.6 0.1 2.4e-07 30.8 0.1 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 ELR19283.1 - 4.7e-05 23.7 0.1 9.1e-05 22.8 0.1 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_PNT PF02198.16 ELR19283.1 - 0.00019 21.4 0.0 0.00037 20.4 0.0 1.5 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain PAS_4 PF08448.10 ELR19283.1 - 0.00027 21.1 0.0 0.0069 16.6 0.0 2.4 2 1 0 2 2 2 1 PAS fold PAS PF00989.25 ELR19283.1 - 0.001 19.1 0.0 0.032 14.2 0.0 2.4 2 0 0 2 2 2 1 PAS fold PAS_8 PF13188.7 ELR19283.1 - 0.0033 17.4 0.0 3.8 7.6 0.0 2.5 2 0 0 2 2 2 2 PAS domain PAS_12 PF18095.1 ELR19283.1 - 0.079 12.6 0.1 0.87 9.2 0.0 2.6 3 0 0 3 3 3 0 UPF0242 C-terminal PAS-like domain Metallophos PF00149.28 ELR19284.1 - 3.9e-15 56.9 1.0 6.7e-15 56.1 0.1 1.7 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase SapB_1 PF05184.15 ELR19285.1 - 1.2e-06 28.4 3.1 2.2e-06 27.6 3.1 1.4 1 0 0 1 1 1 1 Saposin-like type B, region 1 DNA_pol_A PF00476.20 ELR19286.1 - 7.8e-103 344.4 0.0 1e-101 340.7 0.0 2.0 1 1 0 1 1 1 1 DNA polymerase family A Ter PF05472.11 ELR19286.1 - 0.023 13.7 0.0 0.045 12.8 0.0 1.4 1 0 0 1 1 1 0 DNA replication terminus site-binding protein (Ter protein) Peptidase_M28 PF04389.17 ELR19287.1 - 1.1e-37 129.7 0.0 1.6e-37 129.1 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M28 Peptidase_M20 PF01546.28 ELR19287.1 - 1.1e-07 31.7 0.2 1e-06 28.6 0.2 2.1 1 1 0 1 1 1 1 Peptidase family M20/M25/M40 Peptidase_M42 PF05343.14 ELR19287.1 - 0.001 18.1 0.0 0.0047 16.0 0.0 1.9 2 0 0 2 2 2 1 M42 glutamyl aminopeptidase Spond_N PF06468.13 ELR19287.1 - 0.065 13.3 0.0 0.13 12.4 0.0 1.4 1 0 0 1 1 1 0 Spondin_N Sec15 PF04091.12 ELR19287.1 - 0.12 11.8 0.0 0.23 10.8 0.0 1.4 1 0 0 1 1 1 0 Exocyst complex subunit Sec15-like AMP-binding PF00501.28 ELR19288.1 - 8.6e-55 186.0 0.0 1.3e-54 185.4 0.0 1.3 1 0 0 1 1 1 1 AMP-binding enzyme Ank_2 PF12796.7 ELR19288.1 - 6.2e-21 74.8 0.4 7.5e-07 29.6 0.0 5.3 4 1 1 5 5 5 3 Ankyrin repeats (3 copies) Ank_5 PF13857.6 ELR19288.1 - 2.8e-20 72.1 4.3 2.7e-06 27.6 0.2 5.7 4 1 1 5 5 5 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 ELR19288.1 - 2.1e-18 64.5 0.8 0.00049 20.3 0.0 6.1 5 0 0 5 5 5 4 Ankyrin repeat Ank_4 PF13637.6 ELR19288.1 - 5.5e-12 46.0 1.2 0.00011 22.7 0.0 5.1 5 0 0 5 5 5 2 Ankyrin repeats (many copies) Ank PF00023.30 ELR19288.1 - 2.4e-11 43.5 6.4 0.0014 19.0 0.6 7.0 8 0 0 8 8 8 2 Ankyrin repeat AMP-binding_C PF13193.6 ELR19288.1 - 7.4e-06 26.9 0.1 3e-05 24.9 0.0 2.2 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain PP-binding PF00550.25 ELR19288.1 - 0.00021 21.6 0.0 0.00052 20.3 0.0 1.7 1 0 0 1 1 1 1 Phosphopantetheine attachment site DUF4704 PF15787.5 ELR19290.1 - 3e-21 75.9 0.1 6.2e-21 74.9 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4704) Laminin_G_3 PF13385.6 ELR19290.1 - 9.4e-05 22.6 0.0 0.00025 21.2 0.0 1.8 1 1 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily WD40 PF00400.32 ELR19291.1 - 3.9e-13 49.7 5.8 0.00057 20.6 0.1 3.9 3 0 0 3 3 3 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ELR19291.1 - 0.00013 22.2 0.0 6.8 7.1 0.0 4.3 3 2 2 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain NMT1 PF09084.11 ELR19291.1 - 0.027 14.4 0.0 0.74 9.7 0.0 2.2 2 0 0 2 2 2 0 NMT1/THI5 like Mem_trans PF03547.18 ELR19292.1 - 0.086 11.2 6.3 2 6.7 7.0 2.1 2 0 0 2 2 2 0 Membrane transport protein Pkinase_Tyr PF07714.17 ELR19294.1 - 1.7e-32 112.7 0.0 1.6e-31 109.5 0.0 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ELR19294.1 - 2.8e-32 112.1 0.0 6.4e-32 111.0 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Kdo PF06293.14 ELR19294.1 - 8.5e-06 25.3 0.0 1.4e-05 24.5 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family polyprenyl_synt PF00348.17 ELR19295.1 - 1.1e-72 244.2 0.0 1.4e-72 243.8 0.0 1.1 1 0 0 1 1 1 1 Polyprenyl synthetase Peptidase_S8 PF00082.22 ELR19297.1 - 1.1e-34 120.1 0.1 3.7e-34 118.3 0.1 1.8 1 1 0 1 1 1 1 Subtilase family DUSP PF06337.12 ELR19300.1 - 2.7e-18 66.4 0.0 2.7e-16 60.0 0.0 2.3 1 1 0 1 1 1 1 DUSP domain Med8 PF10232.9 ELR19301.1 - 2.3e-09 37.2 0.6 3.2e-09 36.7 0.6 1.3 1 0 0 1 1 1 1 Mediator of RNA polymerase II transcription complex subunit 8 Hemerythrin PF01814.23 ELR19301.1 - 0.024 15.3 0.2 11 6.7 0.0 2.4 2 1 0 2 2 2 0 Hemerythrin HHE cation binding domain HSF_DNA-bind PF00447.17 ELR19303.1 - 3.3e-22 78.9 0.0 8.1e-22 77.7 0.0 1.7 1 0 0 1 1 1 1 HSF-type DNA-binding Mit_ribos_Mrp51 PF11709.8 ELR19303.1 - 0.014 15.0 3.4 0.029 14.0 3.4 1.5 1 0 0 1 1 1 0 Mitochondrial ribosomal protein subunit KIAA1430 PF13879.6 ELR19303.1 - 1.2 9.9 13.2 9.7 7.0 13.2 2.3 1 1 0 1 1 1 0 KIAA1430 homologue LRR_6 PF13516.6 ELR19306.1 - 0.0017 18.3 7.2 3.1 8.1 0.1 5.0 5 0 0 5 5 5 2 Leucine Rich repeat LRR_4 PF12799.7 ELR19306.1 - 0.0024 18.3 1.7 16 6.1 0.1 4.1 3 1 1 4 4 4 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 ELR19306.1 - 0.69 9.7 2.8 7 6.5 0.1 3.3 3 0 0 3 3 3 0 Leucine rich repeat LRR_8 PF13855.6 ELR19307.1 - 2.6e-36 123.2 34.4 5.1e-09 35.8 1.9 7.7 3 3 5 9 9 9 8 Leucine rich repeat LRR_4 PF12799.7 ELR19307.1 - 1.2e-29 101.8 33.3 4.7e-05 23.7 0.6 9.6 4 2 6 11 11 11 11 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 ELR19307.1 - 5.2e-07 29.3 11.1 0.042 13.4 2.2 4.9 3 3 1 4 4 4 2 Leucine-rich repeat LRR_1 PF00560.33 ELR19307.1 - 6.8e-07 29.0 27.0 26 5.9 0.0 12.2 12 2 0 12 12 12 1 Leucine Rich Repeat LRR_2 PF07723.13 ELR19307.1 - 0.037 14.7 0.0 14 6.6 0.0 3.1 2 0 0 2 2 2 0 Leucine Rich Repeat DUF4423 PF14394.6 ELR19307.1 - 0.23 11.2 0.0 0.46 10.2 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4423) Kelch_6 PF13964.6 ELR19308.1 - 3e-20 71.8 21.4 0.024 14.9 0.1 8.1 9 0 0 9 9 9 7 Kelch motif Kelch_4 PF13418.6 ELR19308.1 - 4.8e-20 71.3 26.5 0.0002 21.3 0.5 7.6 6 1 1 7 7 7 6 Galactose oxidase, central domain Kelch_1 PF01344.25 ELR19308.1 - 6.5e-18 64.1 14.5 0.012 15.2 0.4 7.4 7 0 0 7 7 7 5 Kelch motif Kelch_2 PF07646.15 ELR19308.1 - 2.4e-09 36.8 8.0 1.2 9.2 0.0 6.7 7 0 0 7 7 7 4 Kelch motif Kelch_5 PF13854.6 ELR19308.1 - 0.081 12.9 27.9 7.7 6.6 0.7 7.5 6 1 1 7 7 7 0 Kelch motif GH114_assoc PF14741.6 ELR19308.1 - 8.5 6.6 15.1 28 4.9 0.3 5.2 3 1 1 5 5 5 0 N-terminal glycosyl-hydrolase-114-associated domain SR-25 PF10500.9 ELR19309.1 - 0.0089 15.7 1.5 0.013 15.1 1.5 1.2 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein DUF4570 PF15134.6 ELR19309.1 - 0.16 12.0 0.8 0.28 11.2 0.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4570) LRR_8 PF13855.6 ELR19310.1 - 2.2e-43 145.8 64.3 2.4e-12 46.4 2.6 8.4 1 1 6 8 8 8 8 Leucine rich repeat LRR_4 PF12799.7 ELR19310.1 - 7.3e-43 143.8 74.8 3.1e-06 27.4 2.7 9.6 8 1 1 9 9 9 9 Leucine Rich repeats (2 copies) DUF2322 PF10084.9 ELR19310.1 - 6.4e-06 26.1 1.6 8.9 6.4 0.0 6.0 5 2 2 7 7 7 2 Uncharacterized protein conserved in bacteria (DUF2322) LRR_1 PF00560.33 ELR19310.1 - 9.6e-06 25.5 54.8 0.72 10.6 0.1 14.0 14 2 1 15 15 15 3 Leucine Rich Repeat LRR_9 PF14580.6 ELR19310.1 - 0.0014 18.2 48.4 0.02 14.4 1.2 5.4 2 1 4 6 6 6 5 Leucine-rich repeat RsmF_methylt_CI PF17126.5 ELR19310.1 - 0.044 13.8 3.7 72 3.5 0.0 5.8 5 2 2 7 7 7 0 RsmF rRNA methyltransferase first C-terminal domain Med3 PF11593.8 ELR19310.1 - 0.87 8.7 10.8 1.6 7.9 10.8 1.4 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal CAF-1_p150 PF11600.8 ELR19310.1 - 1.1 8.9 48.7 0.12 12.0 20.1 2.2 2 0 0 2 2 2 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal FAM76 PF16046.5 ELR19310.1 - 1.5 8.1 16.2 0.33 10.3 4.9 2.3 2 0 0 2 2 2 0 FAM76 protein FAM60A PF15396.6 ELR19310.1 - 5.4 6.9 22.5 0.29 11.1 6.9 2.1 2 0 0 2 2 2 0 Protein Family FAM60A MaoC_dehydratas PF01575.19 ELR19311.1 - 2.2e-20 72.5 0.0 2.8e-20 72.1 0.0 1.2 1 0 0 1 1 1 1 MaoC like domain MaoC_dehydrat_N PF13452.6 ELR19311.1 - 3.8e-06 27.1 0.0 1.4e-05 25.2 0.0 1.8 1 1 0 1 1 1 1 N-terminal half of MaoC dehydratase PRP3 PF08572.10 ELR19312.1 - 7.6e-65 218.8 17.0 7.6e-65 218.8 17.0 1.8 2 0 0 2 2 2 1 pre-mRNA processing factor 3 (PRP3) DUF1115 PF06544.12 ELR19312.1 - 1.1e-42 145.5 0.3 1.1e-42 145.5 0.3 2.8 3 0 0 3 3 3 1 Protein of unknown function (DUF1115) Peptidase_S30 PF01577.16 ELR19312.1 - 9.1 5.8 13.3 0.4 10.3 6.6 2.0 2 0 0 2 2 2 0 Potyvirus P1 protease Pep_deformylase PF01327.21 ELR19313.1 - 4.9e-24 84.7 0.0 6.2e-24 84.4 0.0 1.2 1 0 0 1 1 1 1 Polypeptide deformylase Epimerase PF01370.21 ELR19315.1 - 3.9e-33 114.9 0.0 5.8e-33 114.3 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 ELR19315.1 - 1.3e-28 100.4 0.0 4.2e-27 95.4 0.0 2.2 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase 3Beta_HSD PF01073.19 ELR19315.1 - 3.7e-24 85.2 0.0 1.1e-23 83.7 0.0 1.7 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.12 ELR19315.1 - 7e-24 84.4 0.0 3.4e-14 52.6 0.0 2.8 2 1 0 2 2 2 2 Male sterility protein RmlD_sub_bind PF04321.17 ELR19315.1 - 3.7e-14 52.5 0.0 5.3e-14 52.0 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain NAD_binding_10 PF13460.6 ELR19315.1 - 1.5e-09 38.0 0.0 2.4e-09 37.4 0.0 1.4 1 0 0 1 1 1 1 NAD(P)H-binding Polysacc_synt_2 PF02719.15 ELR19315.1 - 1.6e-05 24.2 0.1 0.2 10.8 0.1 2.7 2 1 0 2 2 2 2 Polysaccharide biosynthesis protein NmrA PF05368.13 ELR19315.1 - 2.1e-05 24.2 0.3 0.23 11.0 0.5 3.1 2 1 0 2 2 2 2 NmrA-like family adh_short PF00106.25 ELR19315.1 - 5.8e-05 22.6 0.1 0.018 14.5 0.0 2.5 2 1 0 3 3 3 2 short chain dehydrogenase KR PF08659.10 ELR19315.1 - 0.00096 19.1 0.1 1.2 9.0 0.2 2.4 1 1 1 2 2 2 2 KR domain DFP PF04127.15 ELR19315.1 - 0.056 13.3 0.0 0.1 12.4 0.0 1.3 1 0 0 1 1 1 0 DNA / pantothenate metabolism flavoprotein F420_oxidored PF03807.17 ELR19315.1 - 0.076 13.6 0.0 0.19 12.3 0.0 1.7 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent GP70 PF17429.2 ELR19315.1 - 0.081 12.8 0.4 14 5.6 0.0 2.9 3 0 0 3 3 3 0 Gene product 70 DUF2868 PF11067.8 ELR19316.1 - 0.15 11.5 0.0 0.19 11.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2868) Seryl_tRNA_N PF02403.22 ELR19316.1 - 0.51 10.6 4.0 0.56 10.5 0.4 2.4 2 1 1 3 3 3 0 Seryl-tRNA synthetase N-terminal domain Phage_integrase PF00589.22 ELR19317.1 - 0.05 13.4 0.0 0.099 12.4 0.0 1.5 2 0 0 2 2 2 0 Phage integrase family Pkinase_Tyr PF07714.17 ELR19318.1 - 3.3e-49 167.5 0.0 6.3e-49 166.6 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ELR19318.1 - 5.4e-32 111.2 0.0 1.5e-31 109.8 0.0 1.7 1 0 0 1 1 1 1 Protein kinase domain Kinase-like PF14531.6 ELR19318.1 - 0.0001 21.7 0.0 0.00018 20.9 0.0 1.3 1 0 0 1 1 1 1 Kinase-like DPCD PF14913.6 ELR19318.1 - 0.022 14.1 0.8 3.7 6.8 0.1 2.6 2 0 0 2 2 2 0 DPCD protein family Methyltransf_25 PF13649.6 ELR19318.1 - 0.068 13.9 0.6 5.5 7.8 0.3 3.3 2 0 0 2 2 2 0 Methyltransferase domain Glyco_transf_25 PF01755.17 ELR19318.1 - 6.8 6.5 10.2 4.3 7.1 0.6 3.6 2 1 1 3 3 3 0 Glycosyltransferase family 25 (LPS biosynthesis protein) Keratin_2_head PF16208.5 ELR19319.1 - 0.014 15.6 21.9 0.014 15.6 21.9 2.2 2 0 0 2 2 2 0 Keratin type II head KRTAP PF11759.8 ELR19319.1 - 0.027 15.0 24.7 0.06 13.9 24.7 1.6 1 0 0 1 1 1 0 Keratin-associated matrix Sporozoite_P67 PF05642.11 ELR19319.1 - 1.8 6.5 23.9 0.013 13.7 13.5 1.9 2 0 0 2 2 2 0 Sporozoite P67 surface antigen SPRY PF00622.28 ELR19320.1 - 4.2e-09 36.5 0.1 8.5e-09 35.6 0.1 1.5 1 0 0 1 1 1 1 SPRY domain Pkinase_Tyr PF07714.17 ELR19321.1 - 1.4e-40 139.2 0.0 3.4e-35 121.6 0.0 2.2 1 1 1 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 ELR19321.1 - 3.7e-26 92.1 0.0 7.5e-20 71.4 0.0 2.3 1 1 1 2 2 2 2 Protein kinase domain Kinase-like PF14531.6 ELR19321.1 - 0.00024 20.5 0.0 0.00045 19.6 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 ELR19321.1 - 0.17 10.6 0.0 0.32 9.7 0.0 1.3 1 0 0 1 1 1 0 Fungal protein kinase Filo_glycop PF01611.16 ELR19321.1 - 0.45 9.4 6.3 0.85 8.5 6.3 1.3 1 0 0 1 1 1 0 Filovirus glycoprotein I_LWEQ PF01608.17 ELR19322.1 - 0.067 13.4 5.9 0.11 12.8 5.9 1.4 1 0 0 1 1 1 0 I/LWEQ domain Seryl_tRNA_N PF02403.22 ELR19322.1 - 0.27 11.5 3.3 1.4 9.2 2.9 2.1 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain Prefoldin_2 PF01920.20 ELR19323.1 - 2e-12 47.0 16.4 2.6e-12 46.6 16.4 1.2 1 0 0 1 1 1 1 Prefoldin subunit DUF2584 PF10763.9 ELR19323.1 - 0.057 13.6 0.2 0.098 12.8 0.1 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF2584) Fib_alpha PF08702.10 ELR19323.1 - 0.31 11.2 7.7 0.43 10.8 0.9 2.1 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family NAP PF00956.18 ELR19323.1 - 4.1 6.5 9.8 6.5 5.8 8.4 1.7 1 1 0 1 1 1 0 Nucleosome assembly protein (NAP) Palm_thioest PF02089.15 ELR19324.1 - 3.4e-62 210.4 0.0 4e-62 210.2 0.0 1.0 1 0 0 1 1 1 1 Palmitoyl protein thioesterase SPRY PF00622.28 ELR19325.1 - 1.9e-11 44.1 0.0 1.9e-11 44.1 0.0 2.3 2 0 0 2 2 2 1 SPRY domain PH PF00169.29 ELR19325.1 - 4.8e-08 33.5 0.9 3.8e-07 30.6 0.0 2.4 2 0 0 2 2 2 1 PH domain Arm PF00514.23 ELR19325.1 - 0.0036 17.3 3.1 1.3 9.1 0.0 5.5 6 0 0 6 6 6 1 Armadillo/beta-catenin-like repeat HEAT PF02985.22 ELR19325.1 - 0.016 15.5 0.0 4.2 7.9 0.0 4.6 5 0 0 5 5 5 0 HEAT repeat PH_11 PF15413.6 ELR19325.1 - 0.11 12.9 0.0 0.11 12.9 0.0 3.2 4 0 0 4 4 4 0 Pleckstrin homology domain COG4 PF08318.12 ELR19326.1 - 9.5e-70 235.3 1.5 1.9e-69 234.3 1.5 1.5 1 0 0 1 1 1 1 COG4 transport protein DUF3348 PF11828.8 ELR19326.1 - 0.029 14.1 0.0 0.073 12.7 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3348) DUF1722 PF08349.11 ELR19326.1 - 0.1 12.9 2.1 1.1 9.5 0.0 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF1722) CRAL_TRIO PF00650.20 ELR19326.1 - 0.1 12.3 0.7 0.48 10.1 0.8 2.0 2 0 0 2 2 2 0 CRAL/TRIO domain DUF948 PF06103.11 ELR19326.1 - 1.6 9.0 6.9 0.39 11.0 0.4 3.5 4 1 0 4 4 4 0 Bacterial protein of unknown function (DUF948) BCAS3 PF12490.8 ELR19327.1 - 4.8e-15 55.8 0.1 2.1e-11 43.9 0.0 3.2 1 1 1 2 2 2 1 Breast carcinoma amplified sequence 3 WD40 PF00400.32 ELR19327.1 - 0.0019 19.0 0.0 0.68 10.9 0.0 2.9 2 0 0 2 2 2 2 WD domain, G-beta repeat Glycos_transf_2 PF00535.26 ELR19328.1 - 6.7e-05 22.8 0.3 0.25 11.1 0.0 3.3 2 1 0 2 2 2 2 Glycosyl transferase family 2 Glyco_tranf_2_2 PF10111.9 ELR19328.1 - 0.02 14.4 0.0 0.94 8.9 0.0 2.2 2 0 0 2 2 2 0 Glycosyltransferase like family 2 F-actin_cap_A PF01267.17 ELR19329.1 - 7.7e-79 264.9 0.0 2.1e-78 263.5 0.0 1.6 1 1 0 1 1 1 1 F-actin capping protein alpha subunit Pkinase PF00069.25 ELR19330.1 - 5.3e-66 222.7 0.1 7.9e-43 146.7 1.0 2.4 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ELR19330.1 - 1.9e-36 125.7 0.1 7.8e-27 94.2 0.7 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase PH PF00169.29 ELR19330.1 - 2.8e-17 63.1 0.0 7.1e-17 61.8 0.0 1.7 1 0 0 1 1 1 1 PH domain PX PF00787.24 ELR19330.1 - 7.7e-15 54.9 0.2 7.7e-15 54.9 0.2 2.2 2 0 0 2 2 2 1 PX domain APH PF01636.23 ELR19330.1 - 0.0002 21.4 0.0 0.00082 19.4 0.0 2.0 1 1 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.14 ELR19330.1 - 0.00038 19.9 0.1 0.00081 18.8 0.1 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family PH_11 PF15413.6 ELR19330.1 - 0.0027 18.1 3.5 0.0053 17.2 0.5 2.9 2 1 0 2 2 2 1 Pleckstrin homology domain PH_8 PF15409.6 ELR19330.1 - 0.0057 16.9 0.0 0.016 15.5 0.0 1.8 1 0 0 1 1 1 1 Pleckstrin homology domain Kinase-like PF14531.6 ELR19330.1 - 0.016 14.5 0.0 0.016 14.5 0.0 2.5 4 0 0 4 4 4 0 Kinase-like RIO1 PF01163.22 ELR19330.1 - 0.023 14.3 1.0 0.07 12.7 0.2 2.1 1 1 1 2 2 2 0 RIO1 family Ribosomal_L37e PF01907.19 ELR19330.1 - 0.27 11.4 1.5 0.72 10.1 0.1 2.2 2 0 0 2 2 2 0 Ribosomal protein L37e P16-Arc PF04699.14 ELR19330.1 - 0.46 11.0 2.9 1.4 9.4 2.9 1.7 1 0 0 1 1 1 0 ARP2/3 complex 16 kDa subunit (p16-Arc) UPF0149 PF03695.13 ELR19330.1 - 1.5 9.1 4.3 0.44 10.8 0.6 2.1 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0149) F_actin_bund_C PF18060.1 ELR19331.1 - 3.9e-12 46.1 20.1 3.9e-12 46.1 20.1 4.0 2 2 1 3 3 3 1 F actin bundling C terminal DUF4192 PF13830.6 ELR19331.1 - 5.5 7.0 45.7 1.2 9.2 17.6 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4192) THRAP3_BCLAF1 PF15440.6 ELR19331.1 - 9.4 5.1 18.6 12 4.7 18.6 1.1 1 0 0 1 1 1 0 THRAP3/BCLAF1 family zf-C3HC4_2 PF13923.6 ELR19332.1 - 5.2e-11 42.2 8.3 5.2e-11 42.2 8.3 2.0 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 ELR19332.1 - 4.3e-09 36.4 6.4 4.3e-09 36.4 6.4 2.8 2 1 1 3 3 3 1 zinc finger of C3HC4-type, RING zf-C3HC4_3 PF13920.6 ELR19332.1 - 1.4e-08 34.5 5.4 1.4e-08 34.5 5.4 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 ELR19332.1 - 2e-08 34.1 4.8 2e-08 34.1 4.8 2.2 2 1 1 3 3 2 1 RING-type zinc-finger zf-C3HC4 PF00097.25 ELR19332.1 - 2.7e-08 33.6 8.2 2.7e-08 33.6 8.2 2.5 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 ELR19332.1 - 7.4e-08 32.6 7.3 7.4e-08 32.6 7.3 2.5 2 0 0 2 2 2 1 Ring finger domain zf-RING_5 PF14634.6 ELR19332.1 - 3.6e-06 26.8 7.6 3.6e-06 26.8 7.6 2.4 1 1 1 2 2 1 1 zinc-RING finger domain zf-RING_6 PF14835.6 ELR19332.1 - 4.1e-06 26.6 3.1 4.1e-06 26.6 3.1 2.1 2 0 0 2 2 2 1 zf-RING of BARD1-type protein Prok-RING_4 PF14447.6 ELR19332.1 - 1.8e-05 24.5 5.9 5.6e-05 22.9 5.9 1.8 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_4 PF14570.6 ELR19332.1 - 0.004 16.9 5.8 0.004 16.9 5.8 2.5 1 1 1 2 2 1 1 RING/Ubox like zinc-binding domain Rtf2 PF04641.12 ELR19332.1 - 0.011 15.1 3.4 0.013 14.9 1.1 2.2 1 1 1 2 2 2 0 Rtf2 RING-finger zf-RING_10 PF16685.5 ELR19332.1 - 0.02 15.0 3.0 0.02 15.0 3.0 2.3 2 0 0 2 2 2 0 zinc RING finger of MSL2 DUF1272 PF06906.11 ELR19332.1 - 3.9 7.6 15.4 0.044 13.9 6.6 2.3 1 1 1 2 2 1 0 Protein of unknown function (DUF1272) PIG-S PF10510.9 ELR19333.1 - 3.9e-91 306.4 0.1 4.8e-91 306.1 0.1 1.1 1 0 0 1 1 1 1 Phosphatidylinositol-glycan biosynthesis class S protein F_actin_bund_C PF18060.1 ELR19334.1 - 3.8e-17 62.2 22.5 3.8e-17 62.2 22.5 3.6 2 2 1 3 3 3 1 F actin bundling C terminal Rx_N PF18052.1 ELR19334.1 - 0.097 13.0 7.6 0.1 12.9 4.3 2.6 2 0 0 2 2 2 0 Rx N-terminal domain DUF1993 PF09351.10 ELR19334.1 - 0.86 9.7 14.4 0.096 12.8 4.4 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF1993) TBCA PF02970.16 ELR19334.1 - 1.2 9.6 19.7 0.3 11.5 4.6 3.6 2 1 1 3 3 3 0 Tubulin binding cofactor A Vps35 PF03635.17 ELR19335.1 - 1.9e-294 978.9 11.5 2.1e-294 978.7 11.5 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 35 FPL PF09758.9 ELR19335.1 - 0.052 13.5 2.4 0.059 13.4 0.3 2.2 2 1 0 2 2 2 0 Uncharacterised conserved protein ExoD PF06055.12 ELR19336.1 - 0.0088 15.4 0.2 0.011 15.1 0.2 1.1 1 0 0 1 1 1 1 Exopolysaccharide synthesis, ExoD BSP_II PF05432.11 ELR19337.1 - 0.013 15.2 2.1 0.013 15.2 2.1 3.9 4 0 0 4 4 4 0 Bone sialoprotein II (BSP-II) PBP1_TM PF14812.6 ELR19337.1 - 0.016 15.6 15.2 0.016 15.6 15.2 5.9 5 2 0 5 5 5 0 Transmembrane domain of transglycosylase PBP1 at N-terminal BUD22 PF09073.10 ELR19337.1 - 0.081 12.3 41.8 0.072 12.4 15.4 3.3 3 0 0 3 3 3 0 BUD22 Nop14 PF04147.12 ELR19337.1 - 0.12 10.6 36.0 0.029 12.6 7.4 3.1 3 0 0 3 3 3 0 Nop14-like family Zip PF02535.22 ELR19337.1 - 0.42 9.8 11.4 0.79 8.9 1.3 3.1 3 0 0 3 3 3 0 ZIP Zinc transporter TLP-20 PF06088.11 ELR19337.1 - 2.4 8.0 17.6 5.1 7.0 1.3 3.5 3 0 0 3 3 3 0 Nucleopolyhedrovirus telokin-like protein-20 (TLP20) SAPS PF04499.15 ELR19337.1 - 2.7 6.7 14.5 2 7.1 3.2 2.5 2 0 0 2 2 2 0 SIT4 phosphatase-associated protein RR_TM4-6 PF06459.12 ELR19337.1 - 4.2 7.1 21.0 1.3 8.8 1.2 3.8 4 0 0 4 4 4 0 Ryanodine Receptor TM 4-6 Chromo PF00385.24 ELR19338.1 - 1.3e-17 63.4 0.4 1.5e-14 53.6 0.5 2.7 2 0 0 2 2 2 2 Chromo (CHRromatin Organisation MOdifier) domain Chromo_shadow PF01393.19 ELR19338.1 - 2.8e-13 49.7 0.1 4.1e-09 36.4 0.0 2.5 2 0 0 2 2 2 2 Chromo shadow domain Mtf2_C PF14061.6 ELR19338.1 - 0.0065 16.6 0.1 0.012 15.8 0.1 1.4 1 0 0 1 1 1 1 Polycomb-like MTF2 factor 2 AP3D1 PF06375.11 ELR19338.1 - 0.55 10.4 10.4 0.79 9.9 4.1 2.6 2 0 0 2 2 2 0 AP-3 complex subunit delta-1 Myosin_head PF00063.21 ELR19339.1 - 2.9e-252 838.8 0.0 4.6e-252 838.1 0.0 1.3 1 0 0 1 1 1 1 Myosin head (motor domain) MyTH4 PF00784.17 ELR19339.1 - 5.8e-41 139.3 1.1 2.3e-27 95.6 0.2 3.0 2 0 0 2 2 2 2 MyTH4 domain FERM_M PF00373.18 ELR19339.1 - 1.9e-32 112.1 0.0 2.3e-15 57.1 0.0 3.1 2 0 0 2 2 2 2 FERM central domain SH3_2 PF07653.17 ELR19339.1 - 4.3e-10 39.1 0.0 1e-09 37.9 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 ELR19339.1 - 2.9e-09 36.4 0.1 7.9e-09 35.0 0.1 1.8 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 ELR19339.1 - 4e-07 29.8 0.0 8.9e-07 28.7 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain RA PF00788.23 ELR19339.1 - 5.8e-06 26.9 0.0 0.012 16.2 0.0 2.9 2 0 0 2 2 2 2 Ras association (RalGDS/AF-6) domain IQ PF00612.27 ELR19339.1 - 3.5e-05 23.2 14.4 0.076 12.8 0.3 4.6 4 0 0 4 4 4 2 IQ calmodulin-binding motif FERM_N PF09379.10 ELR19339.1 - 0.0011 18.9 0.0 3.1 7.8 0.0 3.4 4 0 0 4 4 3 2 FERM N-terminal domain AAA_16 PF13191.6 ELR19339.1 - 0.0072 16.7 0.0 0.0072 16.7 0.0 3.6 3 0 0 3 3 3 1 AAA ATPase domain TraF PF13728.6 ELR19339.1 - 0.069 13.0 11.2 0.14 11.9 11.2 1.4 1 0 0 1 1 1 0 F plasmid transfer operon protein AAA_22 PF13401.6 ELR19339.1 - 0.096 13.0 0.0 0.92 9.8 0.0 2.8 2 0 0 2 2 1 0 AAA domain V_ATPase_I PF01496.19 ELR19339.1 - 0.23 9.3 3.2 0.37 8.7 3.2 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family CAF-1_p150 PF11600.8 ELR19339.1 - 0.29 10.8 36.7 0.78 9.4 36.7 1.7 1 0 0 1 1 1 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal Paf1 PF03985.13 ELR19339.1 - 1.1 8.2 18.3 2.4 7.1 18.3 1.5 1 0 0 1 1 1 0 Paf1 GAGA_bind PF06217.12 ELR19339.1 - 5.1 7.3 10.7 16 5.6 10.7 1.8 1 0 0 1 1 1 0 GAGA binding protein-like family RNA_polI_A34 PF08208.11 ELR19339.1 - 6.4 6.8 16.6 14 5.7 16.6 1.5 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 Sel1 PF08238.12 ELR19340.1 - 2.3e-99 323.5 63.8 1.5e-08 35.0 0.2 16.5 16 0 0 16 16 16 15 Sel1 repeat U-box PF04564.15 ELR19340.1 - 1.2e-16 60.6 0.1 3.1e-16 59.3 0.0 1.7 2 0 0 2 2 2 1 U-box domain TPR_6 PF13174.6 ELR19340.1 - 1.3e-14 53.7 35.5 0.054 14.1 0.1 13.2 13 1 1 14 14 13 3 Tetratricopeptide repeat TPR_7 PF13176.6 ELR19340.1 - 2.3e-05 24.1 14.2 0.65 10.2 0.3 8.1 6 2 2 8 8 8 2 Tetratricopeptide repeat zf-Nse PF11789.8 ELR19340.1 - 5.6e-05 22.9 0.0 0.00012 21.8 0.0 1.5 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit Tai4 PF16695.5 ELR19340.1 - 0.0011 19.4 6.5 21 5.7 0.0 6.1 4 3 2 6 6 6 0 Type VI secretion system (T6SS), amidase immunity protein TPR_19 PF14559.6 ELR19340.1 - 0.003 18.0 21.9 11 6.7 0.1 9.3 7 3 3 10 10 10 2 Tetratricopeptide repeat zf-NOSIP PF15906.5 ELR19340.1 - 0.011 15.9 0.0 0.031 14.4 0.0 1.7 1 0 0 1 1 1 0 Zinc-finger of nitric oxide synthase-interacting protein zf-rbx1 PF12678.7 ELR19340.1 - 0.18 12.1 2.5 0.21 11.9 0.0 2.5 2 0 0 2 2 1 0 RING-H2 zinc finger domain Transglut_core PF01841.19 ELR19340.1 - 0.51 10.8 4.3 27 5.3 0.1 4.2 3 1 0 3 3 3 0 Transglutaminase-like superfamily TPR_12 PF13424.6 ELR19340.1 - 3.9 7.8 0.0 3.9 7.8 0.0 8.3 6 2 6 12 12 11 0 Tetratricopeptide repeat MIT PF04212.18 ELR19340.1 - 7.9 6.6 17.5 22 5.2 0.1 7.4 10 0 0 10 10 10 0 MIT (microtubule interacting and transport) domain Ribophorin_II PF05817.14 ELR19341.1 - 2.4e-121 406.3 0.2 3e-121 406.0 0.2 1.0 1 0 0 1 1 1 1 Oligosaccharyltransferase subunit Ribophorin II SEN1_N PF12726.7 ELR19341.1 - 0.0012 17.2 2.3 0.0019 16.5 2.3 1.3 1 0 0 1 1 1 1 SEN1 N terminal Nrap_D5 PF17406.2 ELR19341.1 - 0.059 13.1 0.3 0.46 10.2 0.0 2.5 2 0 0 2 2 2 0 Nrap protein PAP/OAS1-like domain 5 Pentapeptide_4 PF13599.6 ELR19342.1 - 3.7e-26 91.1 22.4 4.7e-14 52.3 4.4 3.9 1 1 3 4 4 4 4 Pentapeptide repeats (9 copies) Pentapeptide PF00805.22 ELR19342.1 - 2.6e-21 74.9 23.5 2.9e-09 36.4 3.5 4.8 4 1 1 5 5 5 3 Pentapeptide repeats (8 copies) BTB_2 PF02214.22 ELR19342.1 - 3.4e-16 59.4 0.0 7.6e-16 58.3 0.0 1.6 1 0 0 1 1 1 1 BTB/POZ domain Pentapeptide_3 PF13576.6 ELR19342.1 - 1.1e-06 28.7 18.1 0.0016 18.6 0.1 4.8 3 1 1 4 4 4 2 Pentapeptide repeats (9 copies) BTB_3 PF16017.5 ELR19342.1 - 0.03 14.4 0.0 0.066 13.3 0.0 1.5 1 0 0 1 1 1 0 BTB/POZ domain Pkinase_Tyr PF07714.17 ELR19343.1 - 2.3e-102 341.7 0.1 8.6e-57 192.4 0.0 4.0 2 2 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 ELR19343.1 - 2.1e-88 296.1 0.0 1.4e-49 168.9 0.0 4.0 2 2 0 2 2 2 2 Protein kinase domain 5_nucleotid_C PF02872.18 ELR19343.1 - 5.1e-26 91.8 0.0 9.1e-26 91.0 0.0 1.4 1 0 0 1 1 1 1 5'-nucleotidase, C-terminal domain Kdo PF06293.14 ELR19343.1 - 2.9e-05 23.5 0.0 0.076 12.4 0.0 2.3 2 0 0 2 2 2 2 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 ELR19343.1 - 6.1e-05 22.5 0.0 0.025 13.9 0.0 2.4 2 0 0 2 2 2 2 Kinase-like APH PF01636.23 ELR19343.1 - 0.00014 21.8 0.2 0.019 14.9 0.0 2.5 2 0 0 2 2 2 1 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 ELR19343.1 - 0.0002 20.2 0.0 0.0094 14.8 0.0 2.2 2 0 0 2 2 2 1 Fungal protein kinase FTA2 PF13095.6 ELR19343.1 - 0.00096 18.8 0.0 0.052 13.2 0.0 2.3 2 0 0 2 2 2 1 Kinetochore Sim4 complex subunit FTA2 Haspin_kinase PF12330.8 ELR19343.1 - 0.19 10.7 0.0 19 4.1 0.0 2.2 2 0 0 2 2 2 0 Haspin like kinase domain EGF_2 PF07974.13 ELR19343.1 - 0.7 10.3 6.7 1.9 8.9 6.7 1.7 1 0 0 1 1 1 0 EGF-like domain IU_nuc_hydro PF01156.19 ELR19344.1 - 1.4e-20 74.1 0.0 1.3e-19 70.9 0.0 1.9 1 1 0 1 1 1 1 Inosine-uridine preferring nucleoside hydrolase F-box-like PF12937.7 ELR19345.1 - 3.7e-08 33.1 0.5 6.5e-08 32.3 0.5 1.4 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ELR19345.1 - 0.00026 20.8 0.0 0.00056 19.7 0.0 1.5 1 0 0 1 1 1 1 F-box domain RNF220 PF15926.5 ELR19345.1 - 0.0073 16.0 1.5 0.023 14.4 0.2 2.4 2 0 0 2 2 2 1 E3 ubiquitin-protein ligase RNF220 Methyltrn_RNA_4 PF09936.9 ELR19345.1 - 0.086 12.7 1.3 0.16 11.8 1.3 1.3 1 0 0 1 1 1 0 SAM-dependent RNA methyltransferase F-box_4 PF15966.5 ELR19345.1 - 0.18 11.7 1.3 1.3 9.0 0.0 2.3 2 0 0 2 2 2 0 F-box Palm_thioest PF02089.15 ELR19346.1 - 1.6e-61 208.2 0.0 2e-61 208.0 0.0 1.0 1 0 0 1 1 1 1 Palmitoyl protein thioesterase Hydrolase_4 PF12146.8 ELR19346.1 - 0.013 14.8 0.1 0.058 12.7 0.1 1.9 1 1 0 1 1 1 0 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 ELR19346.1 - 0.014 16.0 0.0 0.017 15.7 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase family DUF2532 PF10811.8 ELR19346.1 - 0.039 14.0 0.0 0.061 13.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2532) DUF676 PF05057.14 ELR19346.1 - 0.11 12.0 0.0 0.32 10.5 0.0 1.7 1 1 0 1 1 1 0 Putative serine esterase (DUF676) FUSC PF04632.12 ELR19348.1 - 0.024 13.2 5.5 0.03 12.9 5.5 1.0 1 0 0 1 1 1 0 Fusaric acid resistance protein family LMBR1 PF04791.16 ELR19348.1 - 0.025 13.5 5.4 0.03 13.2 5.4 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein DUF1917 PF08939.10 ELR19348.1 - 0.068 13.1 11.3 0.11 12.4 11.3 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF1917) TRH PF05438.12 ELR19348.1 - 0.073 12.8 10.4 0.087 12.5 10.4 1.1 1 0 0 1 1 1 0 Thyrotropin-releasing hormone (TRH) Tam41_Mmp37 PF09139.11 ELR19348.1 - 0.16 11.3 4.6 0.19 11.1 4.6 1.0 1 0 0 1 1 1 0 Phosphatidate cytidylyltransferase, mitochondrial DUF3584 PF12128.8 ELR19348.1 - 0.2 9.1 22.0 0.24 8.9 22.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Cob_adeno_trans PF01923.18 ELR19348.1 - 0.38 10.9 8.2 0.77 9.9 8.2 1.5 1 1 0 1 1 1 0 Cobalamin adenosyltransferase Nop53 PF07767.11 ELR19348.1 - 0.5 9.7 24.4 0.64 9.3 24.4 1.1 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) CDC45 PF02724.14 ELR19348.1 - 0.8 7.9 15.6 0.95 7.7 15.6 1.0 1 0 0 1 1 1 0 CDC45-like protein V_ATPase_I PF01496.19 ELR19348.1 - 0.81 7.5 9.6 0.92 7.3 9.6 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family RRN3 PF05327.11 ELR19348.1 - 0.84 8.1 10.5 0.98 7.9 10.5 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 PA26 PF04636.13 ELR19348.1 - 0.85 8.5 10.8 1 8.2 10.8 1.2 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) CRIC_ras_sig PF10534.9 ELR19348.1 - 1.2 9.3 4.5 0.35 11.1 1.0 1.8 2 0 0 2 2 2 0 Connector enhancer of kinase suppressor of ras JCAD PF15351.6 ELR19348.1 - 1.2 6.8 11.6 1.4 6.6 11.6 1.0 1 0 0 1 1 1 0 Junctional protein associated with coronary artery disease Mobilization_B PF17511.2 ELR19348.1 - 1.3 9.4 7.9 0.77 10.1 4.8 1.8 1 1 1 2 2 2 0 Mobilization protein B GREB1 PF15782.5 ELR19348.1 - 2 5.4 7.8 2.4 5.2 7.8 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer DUF2052 PF09747.9 ELR19348.1 - 2.3 8.3 18.9 3.2 7.8 18.9 1.3 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) Atg14 PF10186.9 ELR19348.1 - 2.3 7.2 13.2 3.1 6.8 13.2 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF4094 PF13334.6 ELR19348.1 - 3 8.3 6.9 6.6 7.2 6.9 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4094) Presenilin PF01080.17 ELR19348.1 - 3.2 6.4 6.5 3.6 6.2 6.5 1.1 1 0 0 1 1 1 0 Presenilin Mem_trans PF03547.18 ELR19348.1 - 3.3 6.0 4.8 3.8 5.8 4.8 1.1 1 0 0 1 1 1 0 Membrane transport protein FAM176 PF14851.6 ELR19348.1 - 3.6 7.2 15.3 5 6.8 15.3 1.2 1 0 0 1 1 1 0 FAM176 family DUF4611 PF15387.6 ELR19348.1 - 3.8 7.8 15.1 0.42 10.9 9.7 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4611) HAT_KAT11 PF08214.11 ELR19348.1 - 4.5 6.5 10.0 5.2 6.2 10.0 1.0 1 0 0 1 1 1 0 Histone acetylation protein ALMT PF11744.8 ELR19348.1 - 6.5 5.5 10.2 7.8 5.2 10.2 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter DUF4407 PF14362.6 ELR19348.1 - 6.9 5.9 13.9 11 5.3 13.9 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) SLY PF12485.8 ELR19348.1 - 7.6 7.2 12.4 13 6.4 12.4 1.3 1 1 0 1 1 1 0 Lymphocyte signaling adaptor protein Exonuc_VII_L PF02601.15 ELR19348.1 - 7.8 6.0 12.4 9.7 5.7 12.4 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit Pex26 PF07163.12 ELR19348.1 - 9.3 5.5 11.0 2.4 7.4 7.5 1.7 1 1 1 2 2 2 0 Pex26 protein TMPIT PF07851.13 ELR19348.1 - 9.4 5.4 12.4 16 4.6 12.4 1.4 1 1 0 1 1 1 0 TMPIT-like protein SprA-related PF12118.8 ELR19348.1 - 9.5 5.3 18.3 12 5.0 18.3 1.1 1 0 0 1 1 1 0 SprA-related family Aa_trans PF01490.18 ELR19349.1 - 9.8e-08 31.1 2.8 9.8e-08 31.1 2.8 3.1 2 1 0 3 3 3 2 Transmembrane amino acid transporter protein DUF4229 PF14012.6 ELR19349.1 - 0.14 12.3 0.0 0.14 12.3 0.0 3.7 4 0 0 4 4 4 0 Protein of unknown function (DUF4229) CH PF00307.31 ELR19350.1 - 1.3e-07 31.8 0.2 2.4e-07 30.9 0.2 1.4 1 0 0 1 1 1 1 Calponin homology (CH) domain EB1 PF03271.17 ELR19350.1 - 0.013 15.7 0.3 0.029 14.6 0.3 1.6 1 0 0 1 1 1 0 EB1-like C-terminal motif Auxin_repressed PF05564.12 ELR19350.1 - 1.3 9.8 5.0 2.5 8.8 3.7 2.1 2 0 0 2 2 2 0 Dormancy/auxin associated protein CobT PF06213.12 ELR19350.1 - 3.9 6.8 13.9 7.6 5.8 13.9 1.4 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT RFX_DNA_binding PF02257.15 ELR19351.1 - 5e-34 116.8 0.1 1.3e-33 115.5 0.1 1.7 1 0 0 1 1 1 1 RFX DNA-binding domain Pox_D5 PF03288.16 ELR19351.1 - 0.12 12.9 0.0 0.28 11.7 0.0 1.6 1 0 0 1 1 1 0 Poxvirus D5 protein-like Ribosomal_L2_C PF03947.18 ELR19352.1 - 2.4e-47 160.2 2.6 4e-47 159.5 2.6 1.3 1 0 0 1 1 1 1 Ribosomal Proteins L2, C-terminal domain Ribosomal_L2 PF00181.23 ELR19352.1 - 2.1e-19 69.2 0.1 6.8e-19 67.6 0.1 1.9 1 0 0 1 1 1 1 Ribosomal Proteins L2, RNA binding domain Sod_Fe_C PF02777.18 ELR19353.1 - 7.8e-39 132.0 3.5 2.1e-38 130.6 1.5 2.1 2 0 0 2 2 2 1 Iron/manganese superoxide dismutases, C-terminal domain Sod_Fe_N PF00081.22 ELR19353.1 - 1.5e-24 86.2 0.9 3.7e-24 85.0 0.9 1.7 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, alpha-hairpin domain PITH PF06201.13 ELR19354.1 - 1.8e-33 115.9 0.2 3.7e-33 114.9 0.2 1.5 1 1 0 1 1 1 1 PITH domain RhoGAP PF00620.27 ELR19355.1 - 9.9e-29 100.1 0.1 1.4e-26 93.2 0.0 4.7 2 0 0 2 2 2 1 RhoGAP domain CH PF00307.31 ELR19355.1 - 1.4e-28 99.3 16.1 4e-16 59.2 0.3 5.4 6 0 0 6 6 6 2 Calponin homology (CH) domain CAMSAP_CH PF11971.8 ELR19355.1 - 1.6e-07 31.1 0.2 0.0016 18.2 0.0 3.5 3 0 0 3 3 3 2 CAMSAP CH domain AT_hook PF02178.19 ELR19356.1 - 0.043 13.7 3.5 0.043 13.7 3.5 3.5 3 0 0 3 3 3 0 AT hook motif Pol_alpha_B_N PF08418.10 ELR19356.1 - 7.5 6.4 16.8 9.4 6.1 16.8 1.2 1 0 0 1 1 1 0 DNA polymerase alpha subunit B N-terminal Myb_DNA-bind_6 PF13921.6 ELR19357.1 - 4.2e-11 42.9 0.6 5.7e-11 42.5 0.6 1.2 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-binding PF00249.31 ELR19357.1 - 1.9e-09 37.5 1.4 2.8e-09 37.0 1.4 1.3 1 0 0 1 1 1 1 Myb-like DNA-binding domain MADF_DNA_bdg PF10545.9 ELR19357.1 - 0.0063 16.8 0.3 0.0086 16.4 0.3 1.3 1 0 0 1 1 1 1 Alcohol dehydrogenase transcription factor Myb/SANT-like Myb_DNA-bind_4 PF13837.6 ELR19357.1 - 0.011 16.1 0.7 0.017 15.5 0.7 1.3 1 0 0 1 1 1 0 Myb/SANT-like DNA-binding domain Glyco_hydro_15 PF00723.21 ELR19358.1 - 4.1e-28 98.4 0.2 1.4e-23 83.4 0.0 2.3 1 1 1 2 2 2 2 Glycosyl hydrolases family 15 Glyco_hydro_15 PF00723.21 ELR19359.1 - 9.4e-09 34.6 0.1 1.3e-08 34.1 0.1 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 15 Ncstrn_small PF18266.1 ELR19360.1 - 1e-34 120.0 0.0 2.3e-34 118.9 0.0 1.6 2 0 0 2 2 2 1 Nicastrin small lobe Nicastrin PF05450.15 ELR19360.1 - 3.3e-29 102.0 0.0 7.8e-29 100.8 0.0 1.6 1 1 0 1 1 1 1 Nicastrin Peptidase_M28 PF04389.17 ELR19360.1 - 5e-06 26.3 0.0 7.8e-06 25.7 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M28 Histone PF00125.24 ELR19361.1 - 6.8e-21 75.0 0.1 9.7e-21 74.5 0.1 1.3 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 ELR19361.1 - 5.3e-06 26.6 0.0 1.3e-05 25.4 0.0 1.6 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID_20kDa PF03847.13 ELR19361.1 - 0.0012 19.3 0.0 0.002 18.6 0.0 1.3 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A DUF1931 PF09123.11 ELR19361.1 - 0.071 13.2 0.0 0.11 12.6 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1931) CENP-T_C PF15511.6 ELR19362.1 - 8.2e-09 35.6 0.1 1e-08 35.2 0.1 1.2 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold CENP-S PF15630.6 ELR19362.1 - 0.0001 22.6 0.1 0.00014 22.2 0.1 1.3 1 1 0 1 1 1 1 CENP-S protein TAF PF02969.17 ELR19362.1 - 0.00015 21.8 0.2 0.00021 21.4 0.2 1.3 1 1 0 1 1 1 1 TATA box binding protein associated factor (TAF) Histone PF00125.24 ELR19362.1 - 0.00026 21.4 0.1 0.00029 21.2 0.1 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 ELR19362.1 - 0.00062 20.0 0.1 0.00095 19.4 0.1 1.4 1 1 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID-31kDa PF02291.15 ELR19362.1 - 0.0079 16.3 0.0 0.0094 16.0 0.0 1.1 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit Bromo_TP PF07524.13 ELR19362.1 - 0.01 15.8 0.0 0.014 15.4 0.0 1.2 1 0 0 1 1 1 0 Bromodomain associated HIGH_NTase1_ass PF16581.5 ELR19362.1 - 0.09 12.8 0.1 0.1 12.6 0.1 1.1 1 0 0 1 1 1 0 Cytidyltransferase-related C-terminal region UPF0137 PF03677.13 ELR19362.1 - 0.11 12.3 0.1 0.14 12.0 0.1 1.0 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0137) TAFII28 PF04719.14 ELR19362.1 - 0.14 12.3 0.0 0.17 12.0 0.0 1.2 1 0 0 1 1 1 0 hTAFII28-like protein conserved region Histone PF00125.24 ELR19363.1 - 6.8e-21 75.0 0.1 9.7e-21 74.5 0.1 1.3 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 ELR19363.1 - 5.3e-06 26.6 0.0 1.3e-05 25.4 0.0 1.6 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID_20kDa PF03847.13 ELR19363.1 - 0.0012 19.3 0.0 0.002 18.6 0.0 1.3 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A DUF1931 PF09123.11 ELR19363.1 - 0.071 13.2 0.0 0.11 12.6 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1931) F_actin_bund_C PF18060.1 ELR19364.1 - 6.2e-17 61.5 19.5 6.2e-17 61.5 19.5 3.8 2 1 2 4 4 4 1 F actin bundling C terminal DUF3584 PF12128.8 ELR19364.1 - 0.9 7.0 36.2 0.47 7.9 30.6 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3584) Mis12 PF05859.12 ELR19364.1 - 2.3 8.3 7.8 0.13 12.3 1.2 2.2 2 0 0 2 2 2 0 Mis12 protein Fib_alpha PF08702.10 ELR19364.1 - 4.2 7.5 7.0 3.8 7.7 3.8 2.4 2 1 0 2 2 2 0 Fibrinogen alpha/beta chain family PARG_cat PF05028.14 ELR19365.1 - 1.2e-122 409.5 0.0 3.3e-122 408.0 0.0 1.7 2 0 0 2 2 2 1 Poly (ADP-ribose) glycohydrolase (PARG) GCP_C_terminal PF04130.13 ELR19366.1 - 2.4e-30 106.1 0.0 3.2e-30 105.7 0.0 1.1 1 0 0 1 1 1 1 Gamma tubulin complex component C-terminal GCP_N_terminal PF17681.1 ELR19366.1 - 2.2e-12 47.3 0.0 1e-09 38.5 0.0 2.4 1 1 0 1 1 1 1 Gamma tubulin complex component N-terminal SARAF PF06682.12 ELR19367.1 - 0.018 14.7 7.9 0.021 14.5 7.9 1.0 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis Romo1 PF10247.9 ELR19367.1 - 0.095 13.1 0.1 0.16 12.4 0.0 1.4 2 0 0 2 2 2 0 Reactive mitochondrial oxygen species modulator 1 ATP_bind_3 PF01171.20 ELR19368.1 - 5.8e-44 150.0 0.0 1.4e-43 148.8 0.0 1.7 1 1 0 1 1 1 1 PP-loop family QueC PF06508.13 ELR19368.1 - 0.11 12.0 0.0 0.26 10.8 0.0 1.6 2 0 0 2 2 2 0 Queuosine biosynthesis protein QueC COPIIcoated_ERV PF07970.12 ELR19370.1 - 1.2e-30 107.0 0.0 2.3e-30 106.1 0.0 1.4 1 0 0 1 1 1 1 Endoplasmic reticulum vesicle transporter ERGIC_N PF13850.6 ELR19370.1 - 2.1e-24 85.7 0.2 4.9e-24 84.5 0.0 1.7 2 0 0 2 2 2 1 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) Mac PF12464.8 ELR19371.1 - 1.8e-18 66.5 0.3 3e-18 65.8 0.3 1.4 1 0 0 1 1 1 1 Maltose acetyltransferase Hexapep PF00132.24 ELR19371.1 - 3.7e-11 42.3 9.8 1.3e-10 40.6 5.6 3.0 3 0 0 3 3 3 1 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 ELR19371.1 - 4e-09 36.1 4.7 4e-09 36.1 4.7 2.4 2 0 0 2 2 2 1 Hexapeptide repeat of succinyl-transferase Ank_2 PF12796.7 ELR19372.1 - 7.5e-28 96.9 9.1 6.9e-11 42.6 0.1 3.7 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ELR19372.1 - 6.9e-20 71.1 2.5 7.4e-09 36.0 0.1 4.5 3 2 2 5 5 5 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 ELR19372.1 - 5.8e-17 61.5 4.0 3.9e-06 27.0 0.1 4.6 2 2 2 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 ELR19372.1 - 7.8e-17 59.7 0.4 0.00015 22.0 0.0 5.2 5 0 0 5 5 5 3 Ankyrin repeat Ank PF00023.30 ELR19372.1 - 2.5e-15 56.1 1.0 0.00055 20.3 0.0 5.6 5 1 0 5 5 5 3 Ankyrin repeat SAM_1 PF00536.30 ELR19372.1 - 4.4e-12 46.3 0.2 1e-11 45.1 0.2 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 ELR19372.1 - 1.2e-09 38.1 0.2 3.5e-09 36.6 0.2 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Pterin_bind PF00809.22 ELR19375.1 - 4.7e-82 275.3 0.1 6.7e-82 274.8 0.1 1.2 1 0 0 1 1 1 1 Pterin binding enzyme HPPK PF01288.20 ELR19375.1 - 8e-35 119.7 0.0 2.1e-34 118.4 0.0 1.8 1 0 0 1 1 1 1 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK) FolB PF02152.18 ELR19375.1 - 5.6e-25 88.0 0.9 1.2e-24 87.0 0.9 1.5 1 0 0 1 1 1 1 Dihydroneopterin aldolase Ycf54 PF10674.9 ELR19375.1 - 0.00043 20.5 0.1 0.015 15.6 0.1 2.4 2 0 0 2 2 2 1 Protein of unknown function (DUF2488) SAP PF02037.27 ELR19376.1 - 0.0005 19.7 3.3 0.046 13.5 1.1 3.5 3 0 0 3 3 3 1 SAP domain Oest_recep PF02159.15 ELR19376.1 - 0.021 15.3 4.6 0.063 13.8 4.6 1.8 1 0 0 1 1 1 0 Oestrogen receptor Gyro_capsid PF04162.12 ELR19376.1 - 0.75 8.2 2.3 1.3 7.5 2.3 1.3 1 0 0 1 1 1 0 Gyrovirus capsid protein (VP1) DUF508 PF04370.12 ELR19376.1 - 0.89 9.3 5.4 1.8 8.3 5.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF508) PAP2 PF01569.21 ELR19377.1 - 6.3e-07 29.2 0.1 6.3e-07 29.2 0.1 2.2 2 0 0 2 2 2 1 PAP2 superfamily PHD PF00628.29 ELR19377.1 - 1.3e-06 28.2 2.9 2.1e-06 27.5 2.9 1.4 1 0 0 1 1 1 1 PHD-finger PHD_2 PF13831.6 ELR19377.1 - 0.019 14.5 1.8 0.031 13.8 1.8 1.4 1 0 0 1 1 1 0 PHD-finger C1_1 PF00130.22 ELR19377.1 - 0.032 14.1 0.5 0.032 14.1 0.5 1.8 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Rick_17kDa_Anti PF05433.15 ELR19377.1 - 0.054 13.4 1.3 0.21 11.5 1.3 2.0 1 0 0 1 1 1 0 Glycine zipper 2TM domain Endostatin PF06482.11 ELR19378.1 - 0.043 13.3 4.5 0.072 12.5 4.5 1.3 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin GvpL_GvpF PF06386.11 ELR19378.1 - 0.065 13.2 6.0 0.11 12.5 6.0 1.2 1 0 0 1 1 1 0 Gas vesicle synthesis protein GvpL/GvpF Tim54 PF11711.8 ELR19378.1 - 0.15 10.8 10.6 0.22 10.3 10.6 1.2 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 SAPS PF04499.15 ELR19378.1 - 0.16 10.7 6.0 0.22 10.3 6.0 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein GAGA_bind PF06217.12 ELR19378.1 - 0.3 11.3 9.3 0.53 10.5 9.3 1.4 1 0 0 1 1 1 0 GAGA binding protein-like family FGF-BP1 PF06473.12 ELR19378.1 - 0.38 10.5 14.3 0.6 9.9 13.2 1.7 2 0 0 2 2 2 0 FGF binding protein 1 (FGF-BP1) Zip PF02535.22 ELR19378.1 - 0.62 9.2 4.8 0.65 9.2 4.8 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Presenilin PF01080.17 ELR19378.1 - 0.76 8.5 11.8 1 8.0 11.8 1.2 1 0 0 1 1 1 0 Presenilin Hid1 PF12722.7 ELR19378.1 - 0.82 7.7 8.3 1 7.4 8.3 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein PBP_sp32 PF07222.12 ELR19378.1 - 1.1 8.7 10.7 1.9 7.9 10.7 1.4 1 0 0 1 1 1 0 Proacrosin binding protein sp32 CPSF100_C PF13299.6 ELR19378.1 - 1.9 8.6 10.6 0.72 10.0 6.2 2.1 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal AIF_C PF14721.6 ELR19378.1 - 2.9 8.3 5.4 6.5 7.1 5.4 1.7 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term CDC45 PF02724.14 ELR19378.1 - 4.4 5.5 13.0 5.7 5.1 13.0 1.1 1 0 0 1 1 1 0 CDC45-like protein DAG_kinase_N PF14513.6 ELR19378.1 - 4.5 7.5 12.3 1.4 9.1 9.4 1.6 2 0 0 2 2 2 0 Diacylglycerol kinase N-terminus RNA_pol_Rpc4 PF05132.14 ELR19378.1 - 4.8 7.6 15.2 1.1 9.6 11.3 1.9 2 0 0 2 2 2 0 RNA polymerase III RPC4 Sec62 PF03839.16 ELR19378.1 - 8.6 5.8 12.5 14 5.1 12.5 1.3 1 0 0 1 1 1 0 Translocation protein Sec62 PPL5 PF18168.1 ELR19378.1 - 9.5 5.4 9.7 14 4.8 9.7 1.2 1 0 0 1 1 1 0 Prim-pol family 5 SprT-like PF10263.9 ELR19379.1 - 4.8e-10 39.3 1.7 5.4e-10 39.1 1.7 1.1 1 0 0 1 1 1 1 SprT-like family WLM PF08325.10 ELR19379.1 - 0.13 12.3 0.2 0.15 12.1 0.2 1.1 1 0 0 1 1 1 0 WLM domain WD40 PF00400.32 ELR19380.1 - 5.3e-06 27.1 0.2 1.4e-05 25.7 0.2 1.8 1 0 0 1 1 1 1 WD domain, G-beta repeat PRCC PF10253.9 ELR19381.1 - 1.5 9.6 7.7 3 8.6 7.7 1.5 1 0 0 1 1 1 0 Mitotic checkpoint regulator, MAD2B-interacting SPX PF03105.19 ELR19381.1 - 2.5 7.9 5.9 3.6 7.4 5.9 1.2 1 0 0 1 1 1 0 SPX domain SOG2 PF10428.9 ELR19381.1 - 5.2 6.1 19.7 13 4.8 19.7 1.6 1 0 0 1 1 1 0 RAM signalling pathway protein DEAD PF00270.29 ELR19382.1 - 4.3e-45 153.6 0.6 1e-44 152.4 0.2 1.7 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ELR19382.1 - 1.7e-31 108.9 0.1 3.1e-30 104.7 0.0 2.4 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 ELR19382.1 - 2.3e-05 24.5 0.0 4e-05 23.7 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_30 PF13604.6 ELR19382.1 - 3.1e-05 23.8 0.4 6.2e-05 22.8 0.0 1.7 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.6 ELR19382.1 - 5.7e-05 23.5 0.4 0.0055 17.0 0.2 2.4 2 1 0 2 2 2 1 AAA domain UTP25 PF06862.12 ELR19382.1 - 0.0017 17.2 0.1 1.7 7.3 0.0 2.4 3 0 0 3 3 3 2 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 AAA_22 PF13401.6 ELR19382.1 - 0.011 16.1 0.3 0.04 14.2 0.3 1.9 1 1 0 1 1 1 0 AAA domain Pkinase PF00069.25 ELR19383.1 - 2.2e-05 24.0 0.0 4.7e-05 22.9 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase PF00069.25 ELR19384.1 - 6.8e-40 137.1 0.0 1.4e-39 136.1 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR19384.1 - 1.4e-28 99.9 0.0 3.3e-28 98.7 0.0 1.6 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 ELR19384.1 - 3.6e-05 22.7 1.1 0.00013 20.9 0.0 2.0 2 0 0 2 2 2 1 Fungal protein kinase Kinase-like PF14531.6 ELR19384.1 - 0.0085 15.4 0.0 0.014 14.7 0.0 1.2 1 0 0 1 1 1 1 Kinase-like TED_complement PF07678.14 ELR19385.1 - 4.1e-23 81.9 0.0 8.6e-23 80.8 0.0 1.5 1 0 0 1 1 1 1 A-macroglobulin TED domain SPRY PF00622.28 ELR19385.1 - 3.7e-19 69.0 0.0 6.9e-19 68.1 0.0 1.5 1 0 0 1 1 1 1 SPRY domain A2M PF00207.22 ELR19385.1 - 1.8e-16 59.8 0.3 6.4e-15 54.8 0.2 3.0 2 0 0 2 2 2 1 Alpha-2-macroglobulin family MG2 PF01835.19 ELR19385.1 - 1e-09 38.7 0.4 0.00088 19.7 0.0 4.3 4 0 0 4 4 4 2 MG2 domain bMG10 PF17973.1 ELR19385.1 - 2.1e-05 24.7 0.7 0.0002 21.6 0.0 2.7 3 0 0 3 3 3 1 Bacterial Alpha-2-macroglobulin MG10 domain A2M_recep PF07677.14 ELR19385.1 - 4.4e-05 24.1 0.0 0.00031 21.4 0.0 2.4 2 0 0 2 2 2 1 A-macroglobulin receptor binding domain A2M_BRD PF07703.14 ELR19385.1 - 0.026 14.9 0.2 0.44 10.9 0.1 3.2 3 0 0 3 3 3 0 Alpha-2-macroglobulin bait region domain Big_1 PF02369.16 ELR19385.1 - 0.16 12.0 1.7 0.6 10.2 0.1 2.8 3 0 0 3 3 3 0 Bacterial Ig-like domain (group 1) Big_6 PF17936.1 ELR19385.1 - 0.3 11.4 3.5 0.75 10.1 0.8 2.9 2 0 0 2 2 2 0 Bacterial Ig domain SAM_1 PF00536.30 ELR19386.1 - 2.2e-06 28.0 0.0 6e-06 26.6 0.0 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 ELR19386.1 - 0.00043 20.3 0.0 0.00081 19.5 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Pkinase PF00069.25 ELR19386.1 - 0.0012 18.2 0.0 0.0035 16.7 0.0 1.6 2 0 0 2 2 2 1 Protein kinase domain GvpL_GvpF PF06386.11 ELR19386.1 - 0.02 14.8 0.2 0.16 11.9 0.0 2.1 2 0 0 2 2 2 0 Gas vesicle synthesis protein GvpL/GvpF TSC22 PF01166.18 ELR19386.1 - 0.069 13.5 0.1 12 6.3 0.0 3.2 3 0 0 3 3 3 0 TSC-22/dip/bun family DUF4239 PF14023.6 ELR19386.1 - 0.098 12.4 0.1 0.17 11.6 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4239) HEAT PF02985.22 ELR19387.1 - 0.13 12.5 5.7 56 4.4 0.2 5.4 5 0 0 5 5 5 0 HEAT repeat HEAT_2 PF13646.6 ELR19387.1 - 0.16 12.4 2.8 7.5 7.0 0.0 3.8 4 0 0 4 4 4 0 HEAT repeats CBAH PF02275.18 ELR19388.1 - 4.5e-11 43.0 0.0 2.6e-09 37.2 0.0 2.1 1 1 1 2 2 2 2 Linear amide C-N hydrolases, choloylglycine hydrolase family NAAA-beta PF15508.6 ELR19388.1 - 6e-05 23.3 0.3 0.0007 19.8 0.7 2.5 2 1 0 2 2 2 1 beta subunit of N-acylethanolamine-hydrolyzing acid amidase HEAT_2 PF13646.6 ELR19389.1 - 7.4e-14 51.9 0.3 2.1e-06 28.0 0.3 3.5 4 0 0 4 4 4 2 HEAT repeats Peptidase_M1 PF01433.20 ELR19389.1 - 5.4e-08 32.7 0.1 1.2e-07 31.5 0.1 1.5 1 0 0 1 1 1 1 Peptidase family M1 domain Peptidase_M1_N PF17900.1 ELR19389.1 - 0.001 19.3 0.0 0.0019 18.4 0.0 1.3 1 0 0 1 1 1 1 Peptidase M1 N-terminal domain HEAT_PBS PF03130.16 ELR19389.1 - 0.0024 18.4 10.4 2.7 8.9 4.2 4.6 4 0 0 4 4 4 1 PBS lyase HEAT-like repeat HEAT_EZ PF13513.6 ELR19389.1 - 0.02 15.4 0.3 4.4 7.9 0.1 3.0 2 0 0 2 2 2 0 HEAT-like repeat HEAT PF02985.22 ELR19389.1 - 0.043 14.1 6.0 4 8.0 0.0 4.4 4 0 0 4 4 4 0 HEAT repeat UPF0552 PF10574.9 ELR19390.1 - 1.5e-28 99.6 0.0 2.1e-28 99.2 0.0 1.2 1 0 0 1 1 1 1 Arp2/3-interacting proteins Arpin baeRF_family10 PF18854.1 ELR19390.1 - 0.0048 17.2 1.1 0.0084 16.4 0.4 1.7 2 0 0 2 2 2 1 Bacterial archaeo-eukaryotic release factor family 10 MazE_antitoxin PF04014.18 ELR19390.1 - 0.044 13.7 0.0 0.14 12.1 0.0 1.8 2 0 0 2 2 2 0 Antidote-toxin recognition MazE, bacterial antitoxin Cupin_8 PF13621.6 ELR19391.1 - 7.6e-25 88.1 0.1 7.6e-25 88.1 0.1 1.8 2 0 0 2 2 2 1 Cupin-like domain JmjC PF02373.22 ELR19391.1 - 5.5e-12 46.1 0.0 1.6e-11 44.6 0.0 1.9 1 1 0 1 1 1 1 JmjC domain, hydroxylase F-box PF00646.33 ELR19391.1 - 3.4e-06 26.8 0.0 8.4e-06 25.5 0.0 1.7 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 ELR19391.1 - 1.8e-05 24.5 0.5 3.6e-05 23.6 0.5 1.5 1 0 0 1 1 1 1 F-box-like Cupin_4 PF08007.12 ELR19391.1 - 0.0023 17.5 0.1 0.0091 15.5 0.1 2.0 1 1 0 1 1 1 1 Cupin superfamily protein GPI PF06560.11 ELR19391.1 - 0.018 14.3 0.0 0.033 13.4 0.0 1.4 1 0 0 1 1 1 0 Glucose-6-phosphate isomerase (GPI) Cupin_2 PF07883.11 ELR19391.1 - 0.025 14.3 0.0 0.055 13.2 0.0 1.5 1 0 0 1 1 1 0 Cupin domain Cupin_1 PF00190.22 ELR19391.1 - 0.029 14.0 0.0 0.045 13.4 0.0 1.2 1 0 0 1 1 1 0 Cupin Ank_2 PF12796.7 ELR19392.1 - 3.8e-101 331.8 31.7 1.7e-16 60.5 0.1 6.3 1 1 7 8 8 8 8 Ankyrin repeats (3 copies) Ank PF00023.30 ELR19392.1 - 2.5e-60 198.4 22.1 8.7e-06 26.0 0.1 12.3 13 0 0 13 13 13 10 Ankyrin repeat Ank_4 PF13637.6 ELR19392.1 - 9.9e-59 195.0 10.6 2.7e-10 40.6 0.1 10.8 2 2 7 10 10 10 9 Ankyrin repeats (many copies) Ank_3 PF13606.6 ELR19392.1 - 8.4e-54 173.2 10.2 0.00085 19.6 0.0 12.6 13 0 0 13 13 13 10 Ankyrin repeat Ank_5 PF13857.6 ELR19392.1 - 4.6e-51 170.2 13.5 4.9e-10 39.5 1.1 8.9 5 4 4 9 9 9 8 Ankyrin repeats (many copies) YqzE PF14038.6 ELR19392.1 - 1.2 9.2 5.3 2.1 8.4 5.3 1.3 1 0 0 1 1 1 0 YqzE-like protein SGL PF08450.12 ELR19393.1 - 5.9e-40 137.4 0.0 8.5e-40 136.9 0.0 1.2 1 0 0 1 1 1 1 SMP-30/Gluconolactonase/LRE-like region NHL PF01436.21 ELR19393.1 - 0.00034 20.5 3.7 10 6.4 0.1 5.5 6 0 0 6 6 6 1 NHL repeat SBBP PF06739.11 ELR19393.1 - 0.00047 20.1 0.7 0.05 13.6 0.2 3.2 3 0 0 3 3 3 1 Beta-propeller repeat DUF839 PF05787.13 ELR19393.1 - 0.0049 16.1 0.0 0.91 8.6 0.0 2.8 2 1 1 3 3 3 1 Bacterial protein of unknown function (DUF839) Reg_prop PF07494.11 ELR19393.1 - 0.017 15.3 0.3 22 5.7 0.0 4.3 4 0 0 4 4 4 0 Two component regulator propeller Str_synth PF03088.16 ELR19393.1 - 0.094 12.8 0.0 0.32 11.1 0.0 1.9 2 0 0 2 2 2 0 Strictosidine synthase eIF3_subunit PF08597.10 ELR19393.1 - 0.1 12.5 0.1 0.1 12.5 0.1 2.0 1 1 1 2 2 1 0 Translation initiation factor eIF3 subunit Kelch_1 PF01344.25 ELR19393.1 - 0.11 12.2 0.0 0.39 10.4 0.0 2.0 1 0 0 1 1 1 0 Kelch motif CENP-Q PF13094.6 ELR19393.1 - 0.3 11.3 2.9 0.51 10.5 2.9 1.3 1 0 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit Nucleo_P87 PF07267.11 ELR19393.1 - 0.42 9.4 4.1 0.58 9.0 4.1 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 PBP1_TM PF14812.6 ELR19393.1 - 1.9 8.9 21.7 1.4 9.3 17.8 2.6 1 1 1 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DUF3040 PF11239.8 ELR19393.1 - 2.7 8.3 6.0 2.5 8.5 3.5 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3040) PKcGMP_CC PF16808.5 ELR19393.1 - 3.1 7.7 5.6 6.3 6.7 5.6 1.5 1 0 0 1 1 1 0 Coiled-coil N-terminus of cGMP-dependent protein kinase PX PF00787.24 ELR19394.1 - 1.5e-12 47.5 0.5 3.9e-12 46.2 0.5 1.7 1 0 0 1 1 1 1 PX domain GNAT_acetyltran PF12746.7 ELR19394.1 - 0.066 12.8 0.1 0.1 12.2 0.1 1.3 1 0 0 1 1 1 0 GNAT acetyltransferase OmpH PF03938.14 ELR19394.1 - 1.5 9.2 14.7 3 8.2 14.7 1.4 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) APG6_N PF17675.1 ELR19394.1 - 3.2 8.3 17.3 0.72 10.4 13.8 1.7 2 0 0 2 2 2 0 Apg6 coiled-coil region AAA_17 PF13207.6 ELR19396.1 - 1.9e-11 44.6 1.2 2.8e-11 44.0 0.0 1.9 2 1 0 2 2 1 1 AAA domain AAA_18 PF13238.6 ELR19396.1 - 5.6e-11 43.1 0.3 8.3e-10 39.3 0.0 2.2 1 1 0 2 2 2 1 AAA domain ADK PF00406.22 ELR19396.1 - 2.6e-10 40.6 0.0 4.3e-10 39.9 0.0 1.3 1 0 0 1 1 1 1 Adenylate kinase AAA_33 PF13671.6 ELR19396.1 - 5.1e-07 29.9 0.3 2.8e-06 27.6 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 ELR19396.1 - 0.00052 20.3 0.0 0.014 15.6 0.0 2.2 2 0 0 2 2 2 1 AAA domain dNK PF01712.19 ELR19396.1 - 0.00074 19.4 0.5 0.069 13.0 0.0 2.6 2 1 1 3 3 3 1 Deoxynucleoside kinase ABC_tran PF00005.27 ELR19396.1 - 0.00077 20.0 0.1 0.0017 18.9 0.1 1.5 1 1 0 1 1 1 1 ABC transporter AAA_28 PF13521.6 ELR19396.1 - 0.00093 19.5 0.1 0.0024 18.2 0.1 2.0 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 ELR19396.1 - 0.0013 19.2 0.0 0.0022 18.4 0.0 1.6 1 1 0 1 1 1 1 AAA ATPase domain AAA_30 PF13604.6 ELR19396.1 - 0.0018 18.0 0.9 0.006 16.3 0.6 1.9 2 0 0 2 2 2 1 AAA domain ATP_bind_1 PF03029.17 ELR19396.1 - 0.0067 16.2 0.0 0.0096 15.7 0.0 1.2 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein AAA PF00004.29 ELR19396.1 - 0.0085 16.5 0.0 0.019 15.4 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_19 PF13245.6 ELR19396.1 - 0.013 15.8 0.6 0.037 14.4 0.2 1.9 2 0 0 2 2 2 0 AAA domain Cytidylate_kin PF02224.18 ELR19396.1 - 0.025 14.3 1.0 0.029 14.1 0.0 1.5 2 0 0 2 2 2 0 Cytidylate kinase Rad17 PF03215.15 ELR19396.1 - 0.03 14.3 0.0 0.052 13.5 0.0 1.3 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_24 PF13479.6 ELR19396.1 - 0.052 13.3 0.0 0.1 12.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain RuvB_N PF05496.12 ELR19396.1 - 0.052 13.3 0.1 0.089 12.5 0.1 1.3 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain AAA_5 PF07728.14 ELR19396.1 - 0.053 13.5 0.1 0.11 12.5 0.1 1.5 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) PRK PF00485.18 ELR19396.1 - 0.061 13.0 0.0 0.12 12.1 0.0 1.4 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family Thymidylate_kin PF02223.17 ELR19396.1 - 0.068 12.9 0.4 6.4 6.4 0.0 2.6 3 0 0 3 3 3 0 Thymidylate kinase Hydin_ADK PF17213.3 ELR19396.1 - 0.07 13.4 0.6 0.17 12.1 0.0 1.9 1 1 1 2 2 2 0 Hydin Adenylate kinase-like domain PduV-EutP PF10662.9 ELR19396.1 - 0.092 12.5 0.1 0.15 11.8 0.1 1.3 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation AAA_11 PF13086.6 ELR19396.1 - 0.11 12.2 0.1 0.19 11.5 0.1 1.4 1 0 0 1 1 1 0 AAA domain Ploopntkinase3 PF18751.1 ELR19396.1 - 0.14 12.0 0.0 0.28 11.1 0.0 1.5 1 0 0 1 1 1 0 P-loop Nucleotide Kinase3 cobW PF02492.19 ELR19396.1 - 0.16 11.6 0.1 0.25 10.9 0.1 1.3 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain Mg_chelatase PF01078.21 ELR19396.1 - 0.17 11.2 0.0 0.28 10.5 0.0 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI NTPase_1 PF03266.15 ELR19396.1 - 0.19 11.6 0.5 0.59 10.0 0.2 1.9 2 0 0 2 2 2 0 NTPase DIL PF01843.19 ELR19397.1 - 9.5e-13 48.3 0.1 2.2e-12 47.2 0.1 1.7 1 0 0 1 1 1 1 DIL domain zf-C4H2 PF10146.9 ELR19397.1 - 0.12 12.7 1.2 0.41 10.9 1.2 1.8 1 0 0 1 1 1 0 Zinc finger-containing protein UreE_C PF05194.12 ELR19397.1 - 0.13 12.7 8.5 1.1 9.8 8.5 2.6 1 1 0 1 1 1 0 UreE urease accessory protein, C-terminal domain SAS4 PF15460.6 ELR19397.1 - 0.2 11.8 0.0 0.2 11.8 0.0 2.2 3 0 0 3 3 3 0 Something about silencing, SAS, complex subunit 4 Golgin_A5 PF09787.9 ELR19397.1 - 7 6.0 12.3 14 5.0 12.3 1.5 1 0 0 1 1 1 0 Golgin subfamily A member 5 HEAT PF02985.22 ELR19398.1 - 0.00056 19.9 4.8 0.17 12.2 0.2 5.4 5 0 0 5 5 5 1 HEAT repeat HEAT_2 PF13646.6 ELR19398.1 - 0.014 15.7 6.4 0.77 10.2 0.0 4.8 5 1 0 5 5 5 0 HEAT repeats Cnd1 PF12717.7 ELR19398.1 - 0.078 13.0 0.2 7.5 6.6 0.0 3.1 3 1 0 3 3 3 0 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.22 ELR19400.1 - 0.0001 22.3 7.5 0.16 12.3 0.2 5.2 4 0 0 4 4 4 2 HEAT repeat HEAT_2 PF13646.6 ELR19400.1 - 0.0024 18.2 9.3 0.034 14.5 0.3 4.9 4 2 0 4 4 4 1 HEAT repeats HEAT_EZ PF13513.6 ELR19400.1 - 0.44 11.1 3.7 3.1 8.4 0.0 3.8 4 0 0 4 4 4 0 HEAT-like repeat RhoGEF PF00621.20 ELR19402.1 - 1.3e-37 129.8 0.0 3.6e-37 128.4 0.0 1.7 1 0 0 1 1 1 1 RhoGEF domain PH PF00169.29 ELR19402.1 - 0.00096 19.6 0.0 0.0086 16.6 0.0 2.8 2 1 0 2 2 2 1 PH domain tRNA_bind_4 PF18490.1 ELR19403.1 - 0.0036 17.1 3.3 0.011 15.6 0.3 2.4 1 1 1 2 2 2 1 tRNA-binding domain DUF3232 PF11554.8 ELR19405.1 - 0.0034 17.8 0.6 0.0055 17.1 0.6 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3232) CENP-F_leu_zip PF10473.9 ELR19405.1 - 0.032 14.3 15.3 1.8 8.6 9.8 2.6 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Cep57_CLD_2 PF14197.6 ELR19405.1 - 0.11 12.6 16.4 0.94 9.6 1.3 3.4 2 1 1 3 3 3 0 Centrosome localisation domain of PPC89 DUF4201 PF13870.6 ELR19405.1 - 0.32 10.7 13.6 0.077 12.7 5.7 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4201) Spectrin PF00435.21 ELR19405.1 - 0.85 10.1 17.8 1.3 9.6 4.9 3.1 3 1 1 4 4 4 0 Spectrin repeat Fib_alpha PF08702.10 ELR19405.1 - 2.3 8.4 11.4 1.3 9.2 7.6 2.5 1 1 0 2 2 2 0 Fibrinogen alpha/beta chain family BLOC1_2 PF10046.9 ELR19405.1 - 2.8 8.3 10.2 17 5.8 8.9 2.7 2 1 0 2 2 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 YabA PF06156.13 ELR19405.1 - 3.6 8.3 13.9 1.3 9.7 2.0 3.1 1 1 2 3 3 3 0 Initiation control protein YabA Herpes_UL6 PF01763.16 ELR19405.1 - 3.9 5.9 9.1 6.2 5.2 0.2 2.2 1 1 0 2 2 2 0 Herpesvirus UL6 like FlaC_arch PF05377.11 ELR19405.1 - 4.2 7.8 8.7 9.5 6.7 0.8 3.1 3 0 0 3 3 2 0 Flagella accessory protein C (FlaC) Cauli_AT PF03233.13 ELR19405.1 - 5.7 6.8 8.8 2 8.3 0.4 3.1 2 1 1 3 3 3 0 Aphid transmission protein Spc7 PF08317.11 ELR19405.1 - 5.9 5.7 20.2 1 8.2 13.2 2.3 2 0 0 2 2 2 0 Spc7 kinetochore protein VPS38 PF17649.1 ELR19405.1 - 6.4 5.5 8.5 2.8 6.7 5.7 1.8 1 1 1 2 2 2 0 Vacuolar protein sorting 38 GAS PF13851.6 ELR19405.1 - 9.8 5.5 20.5 0.83 9.0 6.5 2.9 3 0 0 3 3 3 0 Growth-arrest specific micro-tubule binding LIM PF00412.22 ELR19406.1 - 1.9e-22 79.2 20.4 3.4e-14 52.8 5.5 3.9 3 1 1 4 4 4 2 LIM domain CH PF00307.31 ELR19406.1 - 7.7e-11 42.1 0.6 1.8e-10 41.0 0.1 1.9 2 0 0 2 2 2 1 Calponin homology (CH) domain Yippee-Mis18 PF03226.14 ELR19406.1 - 0.08 13.2 7.0 0.29 11.4 2.1 2.6 2 0 0 2 2 2 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly zinc_ribbon_15 PF17032.5 ELR19406.1 - 6.8 7.5 9.5 4.6 8.0 6.0 2.5 1 1 1 2 2 2 0 zinc-ribbon family DHHC PF01529.20 ELR19407.1 - 0.00033 20.8 8.7 0.00033 20.8 8.7 3.8 3 1 0 3 3 3 1 DHHC palmitoyltransferase DUF4834 PF16118.5 ELR19407.1 - 0.0015 19.5 19.6 0.011 16.6 0.7 5.3 5 0 0 5 5 5 2 Domain of unknown function (DUF4834) FtsH_ext PF06480.15 ELR19407.1 - 0.65 10.4 2.4 7 7.1 0.1 2.5 2 0 0 2 2 2 0 FtsH Extracellular CDC45 PF02724.14 ELR19407.1 - 6.8 4.9 19.4 11 4.2 19.4 1.2 1 0 0 1 1 1 0 CDC45-like protein DUF4337 PF14235.6 ELR19407.1 - 7.6 6.6 10.5 1 9.5 3.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4337) 2OG-FeII_Oxy_2 PF13532.6 ELR19408.1 - 4.1e-19 69.5 0.0 1.2e-18 68.0 0.0 1.8 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Methyltransf_11 PF08241.12 ELR19408.1 - 3.4e-07 30.8 0.0 8.4e-07 29.6 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 ELR19408.1 - 4.3e-05 23.4 0.2 9e-05 22.4 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 ELR19408.1 - 0.00012 22.7 0.0 0.00034 21.3 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ELR19408.1 - 0.00032 21.4 0.0 0.00074 20.2 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ELR19408.1 - 0.0098 15.7 0.0 0.019 14.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain RRM_1 PF00076.22 ELR19408.1 - 0.031 14.1 0.0 0.068 13.0 0.0 1.5 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nbl1_Borealin_N PF10444.9 ELR19409.1 - 1.4e-15 56.7 2.0 3e-15 55.6 0.5 2.1 2 0 0 2 2 2 1 Nbl1 / Borealin N terminal Nup54 PF13874.6 ELR19409.1 - 0.11 12.6 1.1 0.26 11.4 1.1 1.7 1 1 0 1 1 1 0 Nucleoporin complex subunit 54 PSK_trans_fac PF07704.11 ELR19409.1 - 0.49 11.2 3.4 1.4 9.8 0.1 2.5 1 1 1 2 2 2 0 Rv0623-like transcription factor Proteasom_PSMB PF10508.9 ELR19410.1 - 1.6e-62 211.6 0.0 2e-62 211.3 0.0 1.0 1 0 0 1 1 1 1 Proteasome non-ATPase 26S subunit RICTOR_M PF14666.6 ELR19410.1 - 0.02 14.7 0.0 11 5.8 0.0 3.5 3 0 0 3 3 3 0 Rapamycin-insensitive companion of mTOR, middle domain HEAT PF02985.22 ELR19410.1 - 0.026 14.8 7.2 1.2e+02 3.4 0.2 6.2 7 0 0 7 7 7 0 HEAT repeat RTTN_N PF14726.6 ELR19410.1 - 0.065 14.0 1.5 0.15 12.9 0.2 2.4 2 0 0 2 2 2 0 Rotatin, an armadillo repeat protein, centriole functioning Methyltransf_11 PF08241.12 ELR19411.1 - 8e-19 68.1 0.0 1.6e-18 67.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ELR19411.1 - 2.6e-15 56.9 0.0 4.4e-15 56.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ELR19411.1 - 1.1e-11 45.3 0.0 1.7e-11 44.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ELR19411.1 - 2.8e-10 40.2 0.0 3.9e-10 39.7 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 ELR19411.1 - 4.9e-09 36.2 0.0 6.8e-09 35.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 ELR19411.1 - 1.3e-08 34.5 0.0 1.8e-08 34.0 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_9 PF08003.11 ELR19411.1 - 0.00032 19.7 0.0 0.0017 17.3 0.0 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF1698) Methyltransf_8 PF05148.15 ELR19411.1 - 0.0019 18.1 0.0 0.3 10.9 0.0 2.3 2 0 0 2 2 2 1 Hypothetical methyltransferase Lactamase_B_3 PF13483.6 ELR19411.1 - 0.0064 16.4 0.0 0.0097 15.8 0.0 1.2 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Methyltransf_7 PF03492.15 ELR19411.1 - 0.022 14.0 0.0 1.8 7.7 0.0 2.3 2 0 0 2 2 2 0 SAM dependent carboxyl methyltransferase MTS PF05175.14 ELR19411.1 - 0.13 11.8 0.0 0.24 10.9 0.0 1.5 1 1 0 1 1 1 0 Methyltransferase small domain PCMT PF01135.19 ELR19411.1 - 0.2 11.4 0.0 0.27 11.0 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) RhoGEF PF00621.20 ELR19412.1 - 1.2e-28 100.5 1.7 1.7e-28 100.1 1.7 1.2 1 0 0 1 1 1 1 RhoGEF domain PH PF00169.29 ELR19412.1 - 2e-09 37.9 0.0 1.1e-06 29.1 0.0 2.5 2 0 0 2 2 2 2 PH domain IQ_SEC7_PH PF16453.5 ELR19412.1 - 0.001 19.0 0.0 0.0021 18.0 0.0 1.5 1 0 0 1 1 1 1 PH domain PH_13 PF16652.5 ELR19412.1 - 0.033 14.0 0.1 0.088 12.6 0.1 1.7 1 1 0 1 1 1 0 Pleckstrin homology domain PH_2 PF08458.10 ELR19412.1 - 0.57 10.6 2.4 1.8 8.9 0.4 2.5 2 1 0 2 2 2 0 Plant pleckstrin homology-like region BTB PF00651.31 ELR19413.1 - 1e-18 67.5 0.1 2.7e-18 66.2 0.1 1.8 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.15 ELR19413.1 - 5.1e-09 36.2 3.0 1.8e-07 31.2 1.1 2.5 2 0 0 2 2 2 2 BTB And C-terminal Kelch DUF3824 PF12868.7 ELR19413.1 - 0.032 14.9 1.4 0.032 14.9 1.4 2.0 3 0 0 3 3 3 0 Domain of unknwon function (DUF3824) Ribosomal_60s PF00428.19 ELR19413.1 - 3 8.5 8.5 4.7 7.9 4.7 2.9 2 0 0 2 2 2 0 60s Acidic ribosomal protein BACK PF07707.15 ELR19414.1 - 2.3e-08 34.0 1.1 3.8e-08 33.3 1.1 1.4 1 0 0 1 1 1 1 BTB And C-terminal Kelch RhoGEF PF00621.20 ELR19415.1 - 4.8e-30 105.1 0.4 1.2e-29 103.8 0.3 1.8 2 0 0 2 2 2 1 RhoGEF domain PH PF00169.29 ELR19415.1 - 0.0024 18.3 0.0 0.012 16.1 0.0 2.2 1 1 0 1 1 1 1 PH domain DUF2362 PF10154.9 ELR19416.1 - 1.3 7.8 14.0 1.7 7.5 14.0 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2362) Metal_resist PF13801.6 ELR19416.1 - 7.8 6.7 8.6 2.2 8.5 4.6 1.9 1 1 0 2 2 2 0 Heavy-metal resistance Ank_2 PF12796.7 ELR19417.1 - 3.9e-37 126.7 5.9 4.2e-15 56.1 0.8 4.1 4 1 1 5 5 5 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ELR19417.1 - 1.1e-29 102.4 1.8 2e-08 34.6 0.2 6.1 3 1 3 6 6 6 5 Ankyrin repeats (many copies) Ank PF00023.30 ELR19417.1 - 2.8e-24 84.5 20.1 9.2e-08 32.2 0.2 7.3 8 0 0 8 8 8 4 Ankyrin repeat Ank_5 PF13857.6 ELR19417.1 - 4.6e-23 81.0 11.4 1.7e-06 28.2 0.9 4.9 3 2 2 5 5 5 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 ELR19417.1 - 5e-23 78.7 9.7 1.5e-05 25.0 0.0 7.0 8 0 0 8 8 8 4 Ankyrin repeat UBA PF00627.31 ELR19417.1 - 1e-06 28.5 0.0 0.076 12.9 0.0 3.2 3 0 0 3 3 3 2 UBA/TS-N domain AMNp_N PF10423.9 ELR19417.1 - 0.019 14.6 0.0 5.4 6.6 0.0 2.4 2 0 0 2 2 2 0 Bacterial AMP nucleoside phosphorylase N-terminus CUE PF02845.16 ELR19417.1 - 0.09 12.5 0.0 0.19 11.5 0.0 1.6 1 0 0 1 1 1 0 CUE domain Asp_protease PF09668.10 ELR19418.1 - 2.1e-54 182.6 0.0 3e-54 182.1 0.0 1.2 1 0 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.6 ELR19418.1 - 2.2e-20 73.0 0.0 5e-20 71.9 0.0 1.6 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease ubiquitin PF00240.23 ELR19418.1 - 3.6e-12 45.8 0.0 6.2e-12 45.1 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin family Asp_protease_2 PF13650.6 ELR19418.1 - 1.4e-10 41.6 0.0 3.7e-10 40.3 0.0 1.7 1 0 0 1 1 1 1 Aspartyl protease Rad60-SLD PF11976.8 ELR19418.1 - 5.8e-05 22.8 0.0 0.0001 22.1 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like RVP_2 PF08284.11 ELR19418.1 - 0.00011 22.0 0.0 0.00026 20.8 0.0 1.6 1 0 0 1 1 1 1 Retroviral aspartyl protease RVP PF00077.20 ELR19418.1 - 0.0009 19.5 0.0 0.0024 18.1 0.0 1.7 1 1 0 1 1 1 1 Retroviral aspartyl protease UBA PF00627.31 ELR19418.1 - 0.0034 17.2 0.1 0.012 15.5 0.1 2.1 1 0 0 1 1 1 1 UBA/TS-N domain Ubiquitin_2 PF14560.6 ELR19418.1 - 0.012 16.1 0.0 0.027 14.9 0.0 1.6 1 1 0 1 1 1 0 Ubiquitin-like domain GABP-alpha PF11620.8 ELR19418.1 - 0.016 15.4 0.0 0.039 14.1 0.0 1.6 1 0 0 1 1 1 0 GA-binding protein alpha chain UBA_4 PF14555.6 ELR19418.1 - 0.02 14.7 0.0 0.054 13.3 0.0 1.7 1 0 0 1 1 1 0 UBA-like domain P2X_receptor PF00864.19 ELR19419.1 - 1.8e-11 43.8 1.3 5.3e-06 25.8 0.3 2.2 2 0 0 2 2 2 2 ATP P2X receptor Zip PF02535.22 ELR19419.1 - 0.069 12.4 0.4 0.11 11.7 0.4 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter 2OG-FeII_Oxy_3 PF13640.6 ELR19420.1 - 4.1e-11 43.6 0.0 1.9e-10 41.5 0.0 1.9 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy PF03171.20 ELR19420.1 - 0.13 12.8 0.1 0.31 11.5 0.0 1.7 2 1 0 2 2 2 0 2OG-Fe(II) oxygenase superfamily Spb1_C PF07780.12 ELR19421.1 - 2.7e-51 174.2 21.6 2.7e-51 174.2 21.6 3.8 2 2 1 3 3 3 1 Spb1 C-terminal domain FtsJ PF01728.19 ELR19421.1 - 2.2e-38 132.2 0.0 1.5e-37 129.4 0.0 2.3 2 0 0 2 2 2 1 FtsJ-like methyltransferase DUF3381 PF11861.8 ELR19421.1 - 7.3e-25 87.7 24.8 6.6e-19 68.3 22.7 6.7 4 3 2 6 6 6 2 Domain of unknown function (DUF3381) GST_N_3 PF13417.6 ELR19422.1 - 1.5e-06 28.5 0.0 5.5e-06 26.7 0.0 1.9 1 1 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 ELR19422.1 - 9.2e-06 25.9 0.2 2.3e-05 24.6 0.1 1.8 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 ELR19422.1 - 1.2e-05 25.2 0.1 2.5e-05 24.2 0.1 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 ELR19422.1 - 0.011 15.9 0.0 0.029 14.6 0.0 1.7 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 ELR19422.1 - 0.09 13.0 0.0 0.19 11.9 0.0 1.5 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain Pkinase PF00069.25 ELR19423.1 - 1.6e-63 214.6 0.0 2e-63 214.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR19423.1 - 7.3e-26 91.0 0.0 1.1e-25 90.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase PHD PF00628.29 ELR19423.1 - 1.5e-08 34.4 8.8 2.7e-08 33.6 8.8 1.5 1 0 0 1 1 1 1 PHD-finger FTA2 PF13095.6 ELR19423.1 - 7.4e-06 25.7 0.1 0.0049 16.5 0.0 2.2 2 0 0 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 RIO1 PF01163.22 ELR19423.1 - 0.0032 17.1 0.4 0.0058 16.2 0.2 1.4 1 1 1 2 2 2 1 RIO1 family APH PF01636.23 ELR19423.1 - 0.039 13.9 0.1 0.15 11.9 0.1 1.9 1 1 1 2 2 2 0 Phosphotransferase enzyme family Sporozoite_P67 PF05642.11 ELR19423.1 - 0.054 11.6 0.0 0.054 11.6 0.0 2.5 2 1 0 2 2 2 0 Sporozoite P67 surface antigen PHD_2 PF13831.6 ELR19423.1 - 0.11 12.1 5.3 0.19 11.3 5.3 1.4 1 0 0 1 1 1 0 PHD-finger SWIRM-assoc_2 PF16496.5 ELR19423.1 - 0.45 9.3 2.3 0.74 8.6 2.3 1.2 1 0 0 1 1 1 0 SWIRM-associated domain at the N-terminal RIO1 PF01163.22 ELR19424.1 - 8.1e-70 234.3 0.0 9.5e-54 181.9 0.0 2.7 2 0 0 2 2 2 2 RIO1 family APH PF01636.23 ELR19424.1 - 0.073 13.0 0.0 5.9 6.7 0.0 2.4 1 1 0 2 2 2 0 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 ELR19424.1 - 0.22 10.2 5.6 0.02 13.7 0.4 1.9 2 1 0 2 2 2 0 Fungal protein kinase SRP-alpha_N PF04086.13 ELR19424.1 - 2.8 7.8 20.0 0.073 13.0 7.2 2.1 2 0 0 2 2 2 0 Signal recognition particle, alpha subunit, N-terminal DREV PF05219.12 ELR19425.1 - 1.2e-49 168.8 0.0 3.6e-49 167.2 0.0 1.6 1 1 0 1 1 1 1 DREV methyltransferase Methyltransf_23 PF13489.6 ELR19425.1 - 3.5e-14 53.0 0.0 5.6e-14 52.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ELR19425.1 - 8.2e-09 36.1 0.0 2e-08 34.8 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ELR19425.1 - 4.6e-07 30.4 0.0 1.2e-06 29.0 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ELR19425.1 - 6.9e-06 26.7 0.0 2.4e-05 24.9 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 ELR19425.1 - 0.002 17.9 0.1 0.11 12.3 0.0 2.7 2 1 1 3 3 3 1 Methyltransferase domain PIF1 PF05970.14 ELR19426.1 - 1e-57 196.0 0.0 1.4e-43 149.5 0.0 2.2 2 0 0 2 2 2 2 PIF1-like helicase AAA_30 PF13604.6 ELR19426.1 - 5.6e-21 75.1 0.0 9.9e-21 74.3 0.0 1.4 1 0 0 1 1 1 1 AAA domain Cauli_VI PF01693.16 ELR19426.1 - 1.8e-18 66.6 1.4 5.1e-18 65.1 1.1 2.0 2 0 0 2 2 2 1 Caulimovirus viroplasmin AAA_19 PF13245.6 ELR19426.1 - 2.6e-11 44.1 0.0 6.7e-11 42.7 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_5 PF07728.14 ELR19426.1 - 0.00066 19.7 0.1 0.0025 17.8 0.1 1.9 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 ELR19426.1 - 0.00072 19.8 0.0 0.0019 18.5 0.0 1.6 1 1 0 1 1 1 1 AAA domain Helicase_RecD PF05127.14 ELR19426.1 - 0.0044 16.9 0.5 0.1 12.5 0.5 2.2 1 1 0 1 1 1 1 Helicase Mg_chelatase PF01078.21 ELR19426.1 - 0.0082 15.5 0.1 0.015 14.7 0.1 1.3 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI UvrD-helicase PF00580.21 ELR19426.1 - 0.046 13.3 0.0 0.068 12.7 0.0 1.2 1 0 0 1 1 1 0 UvrD/REP helicase N-terminal domain AAA PF00004.29 ELR19426.1 - 0.046 14.1 0.0 0.079 13.4 0.0 1.3 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) DUF2075 PF09848.9 ELR19426.1 - 0.055 12.7 0.0 0.12 11.6 0.0 1.5 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) NACHT PF05729.12 ELR19426.1 - 0.074 13.0 0.0 0.2 11.6 0.0 1.7 1 0 0 1 1 1 0 NACHT domain AAA_16 PF13191.6 ELR19426.1 - 0.083 13.3 0.1 0.25 11.7 0.1 1.8 1 0 0 1 1 1 0 AAA ATPase domain AAA_11 PF13086.6 ELR19426.1 - 0.15 11.9 0.0 1.6 8.5 0.0 2.2 2 0 0 2 2 2 0 AAA domain ChapFlgA_N PF17656.1 ELR19426.1 - 0.17 12.1 0.0 16 5.7 0.0 2.5 2 0 0 2 2 2 0 FlgA N-terminal domain RhoGEF PF00621.20 ELR19427.1 - 1.2e-21 77.8 0.9 2.2e-19 70.4 0.1 2.1 1 1 1 2 2 2 2 RhoGEF domain F-box PF00646.33 ELR19427.1 - 0.058 13.3 1.4 0.098 12.6 0.1 2.0 2 0 0 2 2 2 0 F-box domain Methyltransf_24 PF13578.6 ELR19428.1 - 5.7e-05 24.1 0.0 0.00013 22.9 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Gelsolin PF00626.22 ELR19430.1 - 1.1e-12 47.7 0.0 4.8e-06 26.4 0.0 3.5 2 0 0 2 2 2 2 Gelsolin repeat Rrn6 PF10214.9 ELR19431.1 - 0.0037 15.8 0.0 0.0037 15.8 0.0 5.2 5 1 1 6 6 6 3 RNA polymerase I-specific transcription-initiation factor Oxysterol_BP PF01237.18 ELR19431.1 - 3 6.6 6.2 6.2 5.5 6.2 1.4 1 0 0 1 1 1 0 Oxysterol-binding protein GST_C_2 PF13410.6 ELR19432.1 - 3.9e-11 42.8 0.2 8.5e-11 41.7 0.2 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 ELR19432.1 - 1.5e-10 41.1 0.0 2.6e-10 40.4 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 ELR19432.1 - 6.6e-09 35.9 0.0 1e-08 35.3 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 ELR19432.1 - 5.3e-08 33.2 0.0 1e-07 32.2 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.20 ELR19432.1 - 0.00097 19.4 0.0 0.0017 18.7 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 ELR19432.1 - 0.0024 18.1 0.0 0.0039 17.4 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_6 PF17171.4 ELR19432.1 - 0.0099 15.7 0.0 0.017 14.9 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_5 PF16865.5 ELR19432.1 - 0.15 12.6 0.0 0.25 11.9 0.0 1.4 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain Peptidase_C26 PF07722.13 ELR19434.1 - 1.4e-15 57.7 0.0 1.2e-14 54.6 0.0 2.1 1 1 0 1 1 1 1 Peptidase C26 GATase PF00117.28 ELR19434.1 - 1.4e-12 47.7 0.0 2.1e-12 47.2 0.0 1.2 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Pex14_N PF04695.13 ELR19435.1 - 0.018 15.7 1.0 0.039 14.6 1.0 1.5 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region NUDIX PF00293.28 ELR19436.1 - 8.2e-19 67.9 0.6 1.7e-18 67.0 0.1 1.7 2 0 0 2 2 2 1 NUDIX domain MRP-L46 PF11788.8 ELR19436.1 - 3.7e-08 34.1 1.0 8.4e-08 33.0 1.0 1.6 1 0 0 1 1 1 1 39S mitochondrial ribosomal protein L46 TPR_1 PF00515.28 ELR19437.1 - 3.3e-21 74.2 7.2 8e-08 31.8 0.0 4.1 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.17 ELR19437.1 - 1.2e-16 59.4 6.6 1.1e-06 28.2 0.1 4.1 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_11 PF13414.6 ELR19437.1 - 6e-09 35.5 4.5 0.0019 17.9 0.0 3.8 3 1 1 4 4 4 3 TPR repeat TPR_8 PF13181.6 ELR19437.1 - 1.5e-08 34.2 5.2 5.2e-05 23.1 0.0 4.0 4 1 1 5 5 5 2 Tetratricopeptide repeat TPR_9 PF13371.6 ELR19437.1 - 1.7e-07 31.3 0.2 3.4e-07 30.3 0.2 1.5 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_16 PF13432.6 ELR19437.1 - 7.8e-06 26.4 0.2 0.0011 19.5 0.0 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_6 PF13174.6 ELR19437.1 - 4.2e-05 23.9 4.9 0.021 15.5 0.2 4.1 4 1 1 5 5 5 1 Tetratricopeptide repeat TPR_14 PF13428.6 ELR19437.1 - 5.1e-05 23.8 1.7 0.018 15.8 0.4 3.2 2 1 2 4 4 4 2 Tetratricopeptide repeat ANAPC3 PF12895.7 ELR19437.1 - 6.9e-05 23.0 4.8 8.8e-05 22.7 0.2 2.5 3 0 0 3 3 3 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 PF13176.6 ELR19437.1 - 0.00011 22.0 0.6 1.7 8.8 0.0 3.7 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_17 PF13431.6 ELR19437.1 - 0.00013 22.1 2.2 0.00067 19.9 0.1 3.2 4 0 0 4 4 4 1 Tetratricopeptide repeat NARP1 PF12569.8 ELR19437.1 - 0.00052 19.1 1.6 0.0055 15.7 0.4 2.0 2 0 0 2 2 2 1 NMDA receptor-regulated protein 1 TPR_12 PF13424.6 ELR19437.1 - 0.0011 19.3 3.1 0.024 14.9 0.1 3.2 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_19 PF14559.6 ELR19437.1 - 0.0016 18.9 5.2 0.011 16.2 0.8 3.3 2 1 1 3 3 3 1 Tetratricopeptide repeat F_actin_bund_C PF18060.1 ELR19438.1 - 2.4e-18 66.0 16.2 2.4e-18 66.0 16.2 4.9 4 2 0 4 4 4 1 F actin bundling C terminal HAP2-GCS1 PF10699.9 ELR19439.1 - 9.6e-16 57.5 0.1 2.3e-15 56.3 0.1 1.7 1 0 0 1 1 1 1 Male gamete fusion factor Sre PF03125.18 ELR19439.1 - 0.05 12.7 0.2 0.097 11.8 0.2 1.3 1 0 0 1 1 1 0 C. elegans Sre G protein-coupled chemoreceptor FapA PF03961.13 ELR19439.1 - 0.76 8.3 4.5 1.3 7.5 4.5 1.3 1 0 0 1 1 1 0 Flagellar Assembly Protein A OmpH PF03938.14 ELR19439.1 - 4.3 7.7 15.9 9.8 6.5 15.9 1.5 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) HSP70 PF00012.20 ELR19440.1 - 6.3e-54 183.2 0.4 1.2e-45 155.9 0.0 2.1 2 0 0 2 2 2 2 Hsp70 protein MreB_Mbl PF06723.13 ELR19440.1 - 0.014 14.2 0.0 0.043 12.6 0.0 1.8 1 0 0 1 1 1 0 MreB/Mbl protein Phage_GPO PF05929.11 ELR19440.1 - 2.9 7.4 6.1 4.4 6.9 6.1 1.2 1 0 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase Rsm22 PF09243.10 ELR19441.1 - 9.7e-54 182.5 0.0 3.6e-51 174.0 0.0 2.1 1 1 0 1 1 1 1 Mitochondrial small ribosomal subunit Rsm22 Methyltransf_23 PF13489.6 ELR19441.1 - 3.6e-08 33.4 0.0 6e-08 32.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ELR19441.1 - 4.5e-06 27.3 0.0 0.00017 22.3 0.0 2.4 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 ELR19441.1 - 5.1e-06 27.1 0.0 1e-05 26.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ELR19441.1 - 0.00017 22.2 0.0 0.00054 20.6 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain DREV PF05219.12 ELR19441.1 - 0.035 13.2 0.0 0.23 10.5 0.0 2.0 2 0 0 2 2 2 0 DREV methyltransferase Methyltransf_31 PF13847.6 ELR19441.1 - 0.043 13.6 0.0 0.13 12.0 0.0 1.7 1 1 1 2 2 2 0 Methyltransferase domain Las1 PF04031.13 ELR19442.1 - 2.3e-44 151.2 0.3 5e-44 150.1 0.3 1.6 1 0 0 1 1 1 1 Las1-like Pkinase PF00069.25 ELR19443.1 - 1.3e-76 257.4 0.0 1.7e-76 257.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR19443.1 - 1.8e-37 129.0 0.0 2.9e-37 128.4 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ELR19443.1 - 3.7e-06 26.5 0.0 5.1e-06 26.0 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 ELR19443.1 - 0.0011 18.0 0.2 0.0019 17.2 0.2 1.3 1 0 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 ELR19443.1 - 0.0022 17.4 0.0 0.0039 16.6 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 ELR19443.1 - 0.07 13.0 0.0 0.16 11.9 0.0 1.6 1 0 0 1 1 1 0 Phosphotransferase enzyme family DUF3292 PF11696.8 ELR19444.1 - 1.6 7.0 4.5 2.2 6.6 4.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3292) WD40 PF00400.32 ELR19446.1 - 9.9e-11 42.0 12.0 0.13 13.2 0.1 6.8 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ELR19446.1 - 0.063 13.6 0.1 4.6 7.6 0.0 3.1 3 0 0 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ELR19446.1 - 0.22 10.5 0.0 1.8 7.4 0.0 2.1 2 0 0 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein PIN_6 PF17146.4 ELR19447.1 - 1.4e-27 96.0 0.0 4.3e-27 94.4 0.0 1.9 1 0 0 1 1 1 1 PIN domain of ribonuclease NOB1_Zn_bind PF08772.11 ELR19447.1 - 5.1e-25 87.4 0.2 1.2e-24 86.3 0.2 1.7 1 0 0 1 1 1 1 Nin one binding (NOB1) Zn-ribbon like Zn-ribbon_8 PF09723.10 ELR19447.1 - 0.039 14.1 1.6 0.084 13.0 1.6 1.6 1 0 0 1 1 1 0 Zinc ribbon domain zf-ribbon_3 PF13248.6 ELR19447.1 - 0.06 12.8 0.2 0.15 11.5 0.2 1.7 1 0 0 1 1 1 0 zinc-ribbon domain Nudix_N_2 PF14803.6 ELR19447.1 - 0.11 12.4 1.0 0.28 11.1 0.1 2.3 2 0 0 2 2 2 0 Nudix N-terminal zinc_ribbon_2 PF13240.6 ELR19447.1 - 0.29 10.9 2.5 0.29 10.9 0.3 2.1 2 0 0 2 2 2 0 zinc-ribbon domain zf-RING_4 PF14570.6 ELR19447.1 - 0.68 9.8 2.4 1.4 8.8 2.4 1.4 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain LAP1C PF05609.12 ELR19447.1 - 1.2 8.1 11.4 2.6 7.0 11.4 1.5 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) zf-RING_11 PF17123.5 ELR19447.1 - 1.5 8.6 3.1 2.7 7.8 3.1 1.4 1 0 0 1 1 1 0 RING-like zinc finger Apt1 PF10351.9 ELR19447.1 - 2.2 7.1 9.0 4.9 5.9 9.0 1.5 1 0 0 1 1 1 0 Golgi-body localisation protein domain SOG2 PF10428.9 ELR19447.1 - 2.3 7.3 11.9 4.3 6.4 11.9 1.5 1 0 0 1 1 1 0 RAM signalling pathway protein Presenilin PF01080.17 ELR19447.1 - 8.6 5.0 9.2 20 3.8 9.2 1.7 1 0 0 1 1 1 0 Presenilin Pkinase_Tyr PF07714.17 ELR19448.1 - 1.7e-08 34.1 0.0 2e-08 33.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ELR19448.1 - 0.00045 19.7 0.0 0.00054 19.4 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR19450.1 - 8.6e-123 408.7 0.0 2.6e-60 203.9 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 ELR19450.1 - 8.7e-106 353.1 0.0 8.2e-54 182.7 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain PBP_like_2 PF12849.7 ELR19450.1 - 1.1e-23 84.3 4.4 1.4e-15 57.8 1.4 2.4 2 0 0 2 2 2 2 PBP superfamily domain Guanylate_cyc PF00211.20 ELR19450.1 - 1.8e-14 53.8 0.0 3.4e-14 52.9 0.0 1.4 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain APH PF01636.23 ELR19450.1 - 1e-06 28.9 0.2 0.00053 20.0 0.0 2.7 2 0 0 2 2 2 1 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 ELR19450.1 - 9.9e-06 24.6 0.0 0.098 11.4 0.1 2.3 2 0 0 2 2 2 2 Fungal protein kinase Kinase-like PF14531.6 ELR19450.1 - 2.1e-05 24.0 0.0 0.16 11.3 0.0 2.3 2 0 0 2 2 2 2 Kinase-like FTA2 PF13095.6 ELR19450.1 - 0.00029 20.5 0.0 0.3 10.7 0.0 3.9 3 1 1 4 4 4 1 Kinetochore Sim4 complex subunit FTA2 EGF_2 PF07974.13 ELR19450.1 - 0.0026 18.1 9.2 0.0049 17.2 9.2 1.5 1 0 0 1 1 1 1 EGF-like domain RIO1 PF01163.22 ELR19450.1 - 0.018 14.7 0.1 1.3 8.5 0.1 2.5 2 1 0 2 2 2 0 RIO1 family Haspin_kinase PF12330.8 ELR19450.1 - 0.018 14.0 0.0 1.2 8.0 0.0 2.2 2 0 0 2 2 2 0 Haspin like kinase domain Kdo PF06293.14 ELR19450.1 - 0.026 13.9 0.2 1.3 8.4 0.1 3.1 3 0 0 3 3 3 0 Lipopolysaccharide kinase (Kdo/WaaP) family SfLAP PF11139.8 ELR19450.1 - 0.051 13.0 1.5 0.14 11.5 1.5 1.7 1 0 0 1 1 1 0 Sap, sulfolipid-1-addressing protein Syndecan PF01034.20 ELR19450.1 - 0.053 13.5 0.2 0.12 12.3 0.2 1.6 1 0 0 1 1 1 0 Syndecan domain RAMP PF04901.13 ELR19450.1 - 0.054 13.5 0.0 0.17 11.9 0.0 1.8 1 0 0 1 1 1 0 Receptor activity modifying family EGF_Tenascin PF18720.1 ELR19450.1 - 0.072 13.2 5.9 0.17 12.0 5.9 1.6 1 0 0 1 1 1 0 Tenascin EGF domain EGF PF00008.27 ELR19450.1 - 0.084 13.2 4.1 0.14 12.4 4.1 1.4 1 0 0 1 1 1 0 EGF-like domain hEGF PF12661.7 ELR19450.1 - 0.3 11.8 2.7 0.64 10.7 2.7 1.6 1 0 0 1 1 1 0 Human growth factor-like EGF Laminin_EGF PF00053.24 ELR19450.1 - 6.4 7.0 6.3 13 6.1 6.3 1.4 1 0 0 1 1 1 0 Laminin EGF domain Pkinase_Tyr PF07714.17 ELR19451.1 - 9.6e-55 185.6 0.0 1.4e-54 185.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ELR19451.1 - 9.3e-41 139.9 0.0 1.5e-40 139.2 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Kdo PF06293.14 ELR19451.1 - 4.7e-05 22.8 0.0 9e-05 21.9 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family SAM_3 PF18016.1 ELR19451.1 - 0.0013 18.5 0.0 0.0033 17.2 0.0 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 ELR19451.1 - 0.0048 17.0 0.0 0.011 15.9 0.0 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 ELR19451.1 - 0.0095 16.4 0.0 0.028 14.9 0.0 1.8 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Kinase-like PF14531.6 ELR19451.1 - 0.066 12.5 0.0 0.11 11.8 0.0 1.2 1 0 0 1 1 1 0 Kinase-like SusD-like_2 PF12771.7 ELR19451.1 - 0.13 11.2 0.0 0.2 10.6 0.0 1.2 1 0 0 1 1 1 0 Starch-binding associating with outer membrane Pkinase_fungal PF17667.1 ELR19451.1 - 0.19 10.5 0.0 0.33 9.7 0.0 1.3 1 0 0 1 1 1 0 Fungal protein kinase tRNA-synt_2b PF00587.25 ELR19452.1 - 1.8e-36 125.8 0.0 2.5e-36 125.3 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.20 ELR19452.1 - 6.9e-13 48.6 0.0 1.5e-12 47.4 0.0 1.6 1 0 0 1 1 1 1 Anticodon binding domain Peptidase_C26 PF07722.13 ELR19453.1 - 4.4e-19 69.1 0.0 7.1e-19 68.4 0.0 1.4 1 0 0 1 1 1 1 Peptidase C26 GATase PF00117.28 ELR19453.1 - 3.7e-09 36.6 0.0 7.5e-09 35.6 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase class-I SNO PF01174.19 ELR19453.1 - 0.058 13.2 0.0 0.39 10.6 0.0 2.2 2 0 0 2 2 2 0 SNO glutamine amidotransferase family DNA_ligase_IV PF11411.8 ELR19453.1 - 0.14 12.3 0.3 0.69 10.1 0.0 2.3 3 0 0 3 3 3 0 DNA ligase IV OTU PF02338.19 ELR19454.1 - 1e-09 38.9 0.0 2.5e-09 37.7 0.0 1.5 1 0 0 1 1 1 1 OTU-like cysteine protease TMEM154 PF15102.6 ELR19454.1 - 0.00096 19.1 0.1 0.00096 19.1 0.1 1.8 2 0 0 2 2 2 1 TMEM154 protein family SID-1_RNA_chan PF13965.6 ELR19454.1 - 0.0026 16.3 0.0 0.0037 15.8 0.0 1.1 1 0 0 1 1 1 1 dsRNA-gated channel SID-1 Orf78 PF06024.12 ELR19454.1 - 0.015 15.6 0.3 0.015 15.6 0.3 3.2 3 0 0 3 3 3 0 Orf78 (ac78) Kei1 PF08552.11 ELR19454.1 - 0.077 12.9 1.8 0.74 9.7 0.0 2.2 2 0 0 2 2 2 0 Inositolphosphorylceramide synthase subunit Kei1 DUF4577 PF15145.6 ELR19454.1 - 0.17 11.9 0.4 0.32 11.0 0.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4577) Synaptobrevin PF00957.21 ELR19454.1 - 0.44 10.4 3.0 0.95 9.3 3.0 1.5 1 0 0 1 1 1 0 Synaptobrevin LAP1C PF05609.12 ELR19454.1 - 0.47 9.5 9.0 8.1 5.4 8.0 2.0 2 0 0 2 2 2 0 Lamina-associated polypeptide 1C (LAP1C) Sigma_reg_N PF13800.6 ELR19454.1 - 1.4 9.3 8.1 3 8.2 8.1 1.5 1 0 0 1 1 1 0 Sigma factor regulator N-terminal Connexin PF00029.19 ELR19454.1 - 1.5 8.5 5.9 7.2 6.3 0.0 2.3 2 0 0 2 2 2 0 Connexin DUF2207 PF09972.9 ELR19454.1 - 2.8 6.6 6.9 0.11 11.2 0.2 1.8 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) CrgA PF06781.12 ELR19454.1 - 3.8 7.6 4.8 4.1 7.5 0.0 2.5 2 0 0 2 2 2 0 Cell division protein CrgA YchF-GTPase_C PF06071.13 ELR19455.1 - 2.3e-39 133.5 0.3 5.8e-39 132.2 0.3 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF933) MMR_HSR1 PF01926.23 ELR19455.1 - 9.6e-22 77.2 0.0 5.7e-21 74.7 0.0 2.1 1 1 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 ELR19455.1 - 8.6e-07 28.6 0.0 1.8e-06 27.5 0.0 1.5 1 0 0 1 1 1 1 Ferrous iron transport protein B Roc PF08477.13 ELR19455.1 - 0.06 13.6 0.0 2.8 8.2 0.0 2.4 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase MeaB PF03308.16 ELR19455.1 - 0.095 11.7 0.0 0.21 10.5 0.0 1.5 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB ABC_tran PF00005.27 ELR19455.1 - 0.11 13.0 0.0 0.37 11.3 0.0 1.8 2 0 0 2 2 2 0 ABC transporter AAA_29 PF13555.6 ELR19455.1 - 0.15 11.8 0.0 0.3 10.9 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain UbiA PF01040.18 ELR19456.1 - 1e-54 185.5 18.4 1.2e-54 185.2 18.4 1.1 1 0 0 1 1 1 1 UbiA prenyltransferase family START PF01852.19 ELR19458.1 - 1.5e-12 47.4 0.0 4.9e-12 45.7 0.0 1.7 1 1 0 1 1 1 1 START domain CPSase_L_D2 PF02786.17 ELR19459.1 - 1.3e-106 354.9 0.3 2.8e-65 219.8 0.1 3.4 2 1 1 3 3 3 3 Carbamoyl-phosphate synthase L chain, ATP binding domain CPSase_sm_chain PF00988.22 ELR19459.1 - 9.8e-49 164.4 0.0 3e-48 162.9 0.0 1.9 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase small chain, CPSase domain OTCace_N PF02729.21 ELR19459.1 - 9.8e-48 161.9 0.0 2e-47 160.9 0.0 1.6 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain GATase PF00117.28 ELR19459.1 - 2.7e-44 151.2 0.0 5e-44 150.3 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase class-I CPSase_L_D3 PF02787.19 ELR19459.1 - 6.6e-40 136.3 0.1 1.7e-39 134.9 0.1 1.8 1 0 0 1 1 1 1 Carbamoyl-phosphate synthetase large chain, oligomerisation domain OTCace PF00185.24 ELR19459.1 - 3e-33 115.1 0.0 5.8e-33 114.2 0.0 1.5 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain ATP-grasp PF02222.22 ELR19459.1 - 2.4e-21 76.0 1.1 3.4e-11 43.0 0.1 3.0 3 0 0 3 3 3 2 ATP-grasp domain Dala_Dala_lig_C PF07478.13 ELR19459.1 - 2.4e-17 63.1 0.3 1.2e-08 34.8 0.0 2.4 2 0 0 2 2 2 2 D-ala D-ala ligase C-terminus MGS PF02142.22 ELR19459.1 - 3.4e-16 59.2 0.0 1.3e-15 57.3 0.0 2.1 2 0 0 2 2 1 1 MGS-like domain Amidohydro_1 PF01979.20 ELR19459.1 - 1.4e-12 47.6 3.8 2.5e-11 43.5 3.4 3.0 2 1 0 2 2 2 1 Amidohydrolase family ATPgrasp_Ter PF15632.6 ELR19459.1 - 5.3e-11 42.4 0.1 7.3e-07 29.0 0.0 3.8 3 0 0 3 3 3 1 ATP-grasp in the biosynthetic pathway with Ter operon ATP-grasp_3 PF02655.14 ELR19459.1 - 2.7e-05 24.3 0.2 0.0013 18.8 0.0 2.6 2 0 0 2 2 2 1 ATP-grasp domain Peptidase_C26 PF07722.13 ELR19459.1 - 0.00011 22.1 0.1 0.0034 17.1 0.1 2.7 1 1 0 1 1 1 1 Peptidase C26 DHOase PF12890.7 ELR19459.1 - 0.016 15.2 0.0 0.037 14.0 0.0 1.6 1 0 0 1 1 1 0 Dihydro-orotase-like ATP-grasp_4 PF13535.6 ELR19459.1 - 0.019 14.6 0.4 0.048 13.3 0.0 1.9 2 0 0 2 2 2 0 ATP-grasp domain ATP-grasp_5 PF13549.6 ELR19459.1 - 0.033 13.6 0.1 0.073 12.5 0.1 1.5 1 0 0 1 1 1 0 ATP-grasp domain Thioredoxin PF00085.20 ELR19460.1 - 3.5e-08 33.3 0.0 3.4e-06 27.0 0.0 2.7 2 1 0 2 2 2 1 Thioredoxin Thioredoxin_2 PF13098.6 ELR19460.1 - 0.033 14.6 0.2 1.6 9.2 0.1 2.6 2 0 0 2 2 2 0 Thioredoxin-like domain HyaE PF07449.11 ELR19460.1 - 0.073 13.0 0.0 0.22 11.5 0.0 1.8 1 0 0 1 1 1 0 Hydrogenase-1 expression protein HyaE FAA_hydrolase PF01557.18 ELR19462.1 - 1.4e-60 204.7 0.0 1.7e-60 204.4 0.0 1.0 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family MTHFR PF02219.17 ELR19464.1 - 4e-123 410.3 0.0 6.3e-123 409.7 0.0 1.3 1 0 0 1 1 1 1 Methylenetetrahydrofolate reductase UQ_con PF00179.26 ELR19465.1 - 2e-37 127.9 0.1 2.7e-37 127.5 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme adh_short PF00106.25 ELR19466.1 - 2e-53 180.7 1.3 2.6e-53 180.4 1.3 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ELR19466.1 - 8.2e-49 166.3 0.7 1.1e-48 165.9 0.7 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ELR19466.1 - 5.3e-08 33.0 2.0 1.8e-07 31.3 2.0 1.8 1 1 0 1 1 1 1 KR domain Epimerase PF01370.21 ELR19466.1 - 8.1e-06 25.5 0.1 1.8e-05 24.4 0.1 1.7 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 ELR19466.1 - 0.00015 20.8 0.1 0.00057 19.0 0.0 1.7 2 0 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.6 ELR19466.1 - 0.0013 18.7 1.0 0.0021 18.0 1.0 1.5 1 1 0 1 1 1 1 NAD(P)H-binding AdoHcyase_NAD PF00670.21 ELR19466.1 - 0.0025 17.9 0.2 0.0025 17.9 0.2 1.6 2 0 0 2 2 2 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain DFP PF04127.15 ELR19466.1 - 0.0026 17.6 0.5 0.0042 16.9 0.5 1.2 1 0 0 1 1 1 1 DNA / pantothenate metabolism flavoprotein THF_DHG_CYH_C PF02882.19 ELR19466.1 - 0.0049 16.2 0.1 0.012 15.0 0.1 1.6 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain LpxI_N PF17930.1 ELR19466.1 - 0.034 14.1 0.1 0.061 13.2 0.1 1.5 1 0 0 1 1 1 0 LpxI N-terminal domain NmrA PF05368.13 ELR19466.1 - 0.057 13.0 0.9 0.1 12.2 0.2 1.7 2 0 0 2 2 2 0 NmrA-like family Methyltransf_25 PF13649.6 ELR19467.1 - 1.1e-14 54.9 0.5 3.2e-13 50.2 0.1 2.3 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 ELR19467.1 - 5e-14 52.7 0.1 1.7e-13 51.0 0.1 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ELR19467.1 - 3.5e-13 49.6 0.1 7.4e-13 48.6 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 ELR19467.1 - 7.2e-11 42.2 0.0 1.2e-10 41.5 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 ELR19467.1 - 8.3e-11 41.7 0.1 2e-10 40.4 0.1 1.6 1 1 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_12 PF08242.12 ELR19467.1 - 3.8e-10 40.4 0.1 1e-09 39.0 0.0 1.8 2 0 0 2 2 1 1 Methyltransferase domain FtsJ PF01728.19 ELR19467.1 - 4.7e-07 30.1 0.0 1.3e-06 28.6 0.0 1.8 1 1 0 1 1 1 1 FtsJ-like methyltransferase Ubie_methyltran PF01209.18 ELR19467.1 - 2.7e-05 23.6 0.0 0.0013 18.1 0.0 2.2 1 1 1 2 2 2 1 ubiE/COQ5 methyltransferase family Methyltransf_9 PF08003.11 ELR19467.1 - 2.8e-05 23.2 0.0 4.3e-05 22.6 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) PCMT PF01135.19 ELR19467.1 - 0.0001 22.1 0.0 0.00015 21.6 0.0 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) DOT1 PF08123.13 ELR19467.1 - 0.00071 19.2 0.0 0.0012 18.4 0.0 1.3 1 0 0 1 1 1 1 Histone methylation protein DOT1 Methyltransf_32 PF13679.6 ELR19467.1 - 0.0031 17.5 0.1 0.0068 16.4 0.1 1.7 1 1 0 1 1 1 1 Methyltransferase domain RrnaAD PF00398.20 ELR19467.1 - 0.0061 15.7 0.0 0.0096 15.0 0.0 1.3 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase MetW PF07021.12 ELR19467.1 - 0.0066 16.1 0.1 0.01 15.4 0.1 1.4 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW MTS PF05175.14 ELR19467.1 - 0.04 13.4 0.0 0.21 11.1 0.0 1.9 2 0 0 2 2 2 0 Methyltransferase small domain ADH_zinc_N PF00107.26 ELR19467.1 - 0.042 13.8 0.0 0.23 11.4 0.0 2.1 2 0 0 2 2 2 0 Zinc-binding dehydrogenase DUF938 PF06080.12 ELR19467.1 - 0.056 13.2 0.0 0.11 12.2 0.0 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF938) Ribosomal_L14e PF01929.17 ELR19468.1 - 1.2e-26 93.0 4.9 2.2e-26 92.2 4.9 1.4 1 0 0 1 1 1 1 Ribosomal protein L14 KOW PF00467.29 ELR19468.1 - 0.065 13.2 0.0 0.12 12.3 0.0 1.4 1 0 0 1 1 1 0 KOW motif Adaptin_N PF01602.20 ELR19469.1 - 1.1e-116 390.5 5.8 1.5e-116 390.0 5.8 1.2 1 0 0 1 1 1 1 Adaptin N terminal region COP-gamma_platf PF08752.10 ELR19469.1 - 1.1e-52 178.2 0.0 2.2e-52 177.2 0.0 1.5 1 0 0 1 1 1 1 Coatomer gamma subunit appendage platform subdomain Coatomer_g_Cpla PF16381.5 ELR19469.1 - 7.8e-32 109.8 0.0 1.7e-31 108.7 0.0 1.6 1 0 0 1 1 1 1 Coatomer subunit gamma-1 C-terminal appendage platform HEAT_2 PF13646.6 ELR19469.1 - 3.4e-18 65.8 5.7 5.7e-10 39.5 0.1 6.2 3 2 4 7 7 7 3 HEAT repeats Cnd1 PF12717.7 ELR19469.1 - 2.4e-13 50.5 7.0 1.1e-05 25.5 0.1 3.5 2 1 1 3 3 3 3 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.22 ELR19469.1 - 1.6e-05 24.7 9.2 3.2 8.3 0.1 6.4 7 0 0 7 7 5 3 HEAT repeat ATPase PF06745.13 ELR19469.1 - 0.0032 16.8 0.2 0.0064 15.9 0.2 1.4 1 0 0 1 1 1 1 KaiC HEAT_EZ PF13513.6 ELR19469.1 - 0.013 16.0 7.9 2.6 8.7 1.4 5.6 6 0 0 6 6 6 0 HEAT-like repeat U3snoRNP10 PF12397.8 ELR19469.1 - 0.09 13.1 6.9 0.77 10.1 1.3 3.7 4 0 0 4 4 4 0 U3 small nucleolar RNA-associated protein 10 Coatomer_b_Cpla PF14806.6 ELR19469.1 - 0.096 12.7 0.2 0.47 10.4 0.0 2.2 2 0 0 2 2 2 0 Coatomer beta subunit appendage platform OS-D PF03392.13 ELR19469.1 - 0.097 12.8 0.4 1.6 8.9 0.0 2.6 2 0 0 2 2 2 0 Insect pheromone-binding family, A10/OS-D UNC45-central PF11701.8 ELR19469.1 - 1.2 9.1 6.0 5.2 7.0 0.1 4.0 6 0 0 6 6 6 0 Myosin-binding striated muscle assembly central Dynactin_p62 PF05502.13 ELR19470.1 - 3.5e-28 98.6 5.7 6.9e-17 61.4 4.6 2.1 1 1 0 2 2 2 2 Dynactin p62 family PH PF00169.29 ELR19471.1 - 1.6e-13 51.0 0.0 4.1e-13 49.8 0.0 1.7 1 0 0 1 1 1 1 PH domain PH_8 PF15409.6 ELR19471.1 - 5.6e-06 26.5 0.1 1.1e-05 25.6 0.1 1.5 1 0 0 1 1 1 1 Pleckstrin homology domain PH_11 PF15413.6 ELR19471.1 - 7.4e-06 26.3 1.3 0.00015 22.1 1.3 2.4 1 1 0 1 1 1 1 Pleckstrin homology domain Exo_endo_phos PF03372.23 ELR19471.1 - 9.9e-06 25.2 0.0 1.7e-05 24.5 0.0 1.4 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family FHA PF00498.26 ELR19472.1 - 1.3e-12 47.9 0.0 2.4e-12 47.0 0.0 1.4 1 0 0 1 1 1 1 FHA domain PHD PF00628.29 ELR19472.1 - 1.2e-10 41.0 8.6 3e-10 39.8 8.6 1.7 1 0 0 1 1 1 1 PHD-finger TFIIF_alpha PF05793.12 ELR19472.1 - 1.4e-06 27.2 31.6 1.9e-06 26.8 31.6 1.3 1 0 0 1 1 1 1 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Yop-YscD_cpl PF16697.5 ELR19472.1 - 2.8e-05 24.3 0.0 0.00014 22.1 0.0 2.0 2 0 0 2 2 2 1 Inner membrane component of T3SS, cytoplasmic domain PHD_2 PF13831.6 ELR19472.1 - 0.00075 19.0 3.1 0.0016 18.0 3.1 1.6 1 0 0 1 1 1 1 PHD-finger Nop14 PF04147.12 ELR19472.1 - 0.0056 15.0 39.8 0.0076 14.5 39.8 1.1 1 0 0 1 1 1 1 Nop14-like family PHD_3 PF13922.6 ELR19472.1 - 0.0082 16.5 4.3 0.0082 16.5 4.3 2.1 2 0 0 2 2 2 1 PHD domain of transcriptional enhancer, Asx SLC12 PF03522.15 ELR19472.1 - 0.18 10.8 12.9 0.24 10.4 12.9 1.2 1 0 0 1 1 1 0 Solute carrier family 12 Coilin_N PF15862.5 ELR19472.1 - 0.18 11.6 16.6 1.2 8.9 15.5 2.4 1 1 1 2 2 2 0 Coilin N-terminus CxC4 PF18717.1 ELR19472.1 - 0.33 10.8 2.2 0.67 9.8 2.2 1.5 1 0 0 1 1 1 0 CxC4 like cysteine cluster associated with KDZ transposases BUD22 PF09073.10 ELR19472.1 - 0.78 9.0 39.8 1.5 8.1 39.8 1.4 1 0 0 1 1 1 0 BUD22 Presenilin PF01080.17 ELR19472.1 - 0.85 8.3 21.6 1.3 7.7 21.6 1.4 1 0 0 1 1 1 0 Presenilin Mpp10 PF04006.12 ELR19472.1 - 1.1 7.6 46.8 1.6 7.1 46.8 1.1 1 0 0 1 1 1 0 Mpp10 protein CDC27 PF09507.10 ELR19472.1 - 1.3 8.3 40.6 2.1 7.6 40.6 1.3 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Macoilin PF09726.9 ELR19472.1 - 1.6 7.2 17.1 2.1 6.8 17.1 1.1 1 0 0 1 1 1 0 Macoilin family CCSAP PF15748.5 ELR19472.1 - 1.9 8.6 28.0 3.7 7.7 28.0 1.5 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated SAPS PF04499.15 ELR19472.1 - 2.4 6.9 18.6 3.1 6.5 18.6 1.2 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein SDA1 PF05285.12 ELR19472.1 - 4.1 6.7 48.3 0.039 13.4 40.6 1.5 2 0 0 2 2 2 0 SDA1 CDC45 PF02724.14 ELR19472.1 - 5.3 5.2 36.9 8.3 4.6 36.9 1.2 1 0 0 1 1 1 0 CDC45-like protein Apt1 PF10351.9 ELR19472.1 - 8.8 5.1 14.1 12 4.6 14.1 1.3 1 0 0 1 1 1 0 Golgi-body localisation protein domain Vfa1 PF08432.10 ELR19472.1 - 8.9 6.6 32.3 20 5.5 32.3 1.6 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Red1 PF07964.11 ELR19472.1 - 9.6 4.3 26.0 13 3.9 26.0 1.1 1 0 0 1 1 1 0 Rec10 / Red1 YiaAB PF05360.14 ELR19473.1 - 9.4e-21 73.8 6.7 3.3e-13 49.6 0.7 2.2 2 0 0 2 2 2 2 yiaA/B two helix domain cNMP_binding PF00027.29 ELR19474.1 - 4.1e-38 129.3 0.5 4.3e-20 71.6 0.0 3.3 3 0 0 3 3 3 3 Cyclic nucleotide-binding domain Cupin_2 PF07883.11 ELR19474.1 - 0.0012 18.5 0.7 0.75 9.6 0.2 2.5 2 0 0 2 2 2 2 Cupin domain CBS PF00571.28 ELR19475.1 - 3e-21 75.6 0.4 1.4e-07 31.8 0.0 4.2 4 0 0 4 4 4 3 CBS domain GST_C_3 PF14497.6 ELR19476.1 - 2.7e-20 72.4 0.0 2.9e-20 72.3 0.0 1.0 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 ELR19476.1 - 3.7e-10 39.9 0.0 4.4e-10 39.7 0.0 1.1 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 ELR19476.1 - 2.2e-05 24.4 0.0 2.9e-05 24.0 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Hamartin PF04388.12 ELR19478.1 - 3.8 6.1 21.7 5 5.7 21.7 1.1 1 0 0 1 1 1 0 Hamartin protein UCR_hinge PF02320.16 ELR19479.1 - 4.4e-17 62.0 0.7 5.5e-17 61.7 0.7 1.1 1 0 0 1 1 1 1 Ubiquinol-cytochrome C reductase hinge protein UPF0203 PF05254.12 ELR19479.1 - 0.013 15.8 5.2 0.26 11.6 4.1 2.1 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0203) PIF1 PF05970.14 ELR19480.1 - 2.8e-09 36.6 0.0 3.7e-09 36.2 0.0 1.1 1 0 0 1 1 1 1 PIF1-like helicase FliD_N PF02465.18 ELR19481.1 - 0.058 14.1 2.5 0.086 13.5 2.5 1.2 1 0 0 1 1 1 0 Flagellar hook-associated protein 2 N-terminus FAM221 PF14753.6 ELR19481.1 - 0.13 11.8 0.7 0.2 11.2 0.7 1.3 1 0 0 1 1 1 0 Protein FAM221A/B Med3 PF11593.8 ELR19481.1 - 0.29 10.3 2.8 0.32 10.1 2.8 1.1 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal PIF1 PF05970.14 ELR19482.1 - 5.2e-53 180.5 0.0 8.8e-52 176.5 0.0 2.0 1 1 0 1 1 1 1 PIF1-like helicase AAA_30 PF13604.6 ELR19482.1 - 3.4e-20 72.6 0.0 1e-19 71.0 0.0 1.7 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.6 ELR19482.1 - 2.1e-10 41.1 0.0 4.9e-10 39.9 0.0 1.7 2 0 0 2 2 1 1 AAA domain Cauli_VI PF01693.16 ELR19482.1 - 8.7e-07 29.2 0.1 2.6e-06 27.6 0.1 1.8 1 0 0 1 1 1 1 Caulimovirus viroplasmin Herpes_Helicase PF02689.14 ELR19482.1 - 2.6e-05 22.4 0.1 0.00058 17.9 0.0 2.5 3 0 0 3 3 3 1 Helicase Viral_helicase1 PF01443.18 ELR19482.1 - 2.8e-05 24.0 0.1 0.12 12.1 0.0 2.8 2 1 0 2 2 2 2 Viral (Superfamily 1) RNA helicase AAA_22 PF13401.6 ELR19482.1 - 0.00016 21.9 0.0 0.00043 20.6 0.0 1.7 1 1 0 1 1 1 1 AAA domain AAA_5 PF07728.14 ELR19482.1 - 0.00066 19.7 0.1 0.0039 17.2 0.1 2.1 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.21 ELR19482.1 - 0.0015 17.9 0.0 0.0028 17.1 0.0 1.4 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA PF00004.29 ELR19482.1 - 0.0044 17.4 0.0 0.0091 16.4 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 ELR19482.1 - 0.007 16.8 0.1 0.017 15.5 0.1 1.6 1 0 0 1 1 1 1 AAA ATPase domain DUF2075 PF09848.9 ELR19482.1 - 0.015 14.6 0.0 0.39 9.9 0.0 2.3 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) UvrD_C_2 PF13538.6 ELR19482.1 - 0.015 15.1 0.0 0.04 13.7 0.0 1.8 1 0 0 1 1 1 0 UvrD-like helicase C-terminal domain Helicase_RecD PF05127.14 ELR19482.1 - 0.053 13.4 0.4 0.61 9.9 0.4 2.2 1 1 0 1 1 1 0 Helicase AAA_7 PF12775.7 ELR19482.1 - 0.077 12.5 0.0 0.28 10.7 0.0 1.8 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_11 PF13086.6 ELR19482.1 - 0.13 12.1 0.1 1.7 8.4 0.0 2.3 2 0 0 2 2 2 0 AAA domain Atg14 PF10186.9 ELR19484.1 - 8.5e-21 74.4 15.9 1.3e-18 67.1 0.0 2.0 2 0 0 2 2 2 2 Vacuolar sorting 38 and autophagy-related subunit 14 VPS38 PF17649.1 ELR19484.1 - 0.03 13.2 9.3 1.7 7.4 9.3 2.1 1 1 0 1 1 1 0 Vacuolar protein sorting 38 Exonuc_VII_L PF02601.15 ELR19484.1 - 7.3 6.1 11.2 10 5.6 11.2 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit EMP70 PF02990.16 ELR19485.1 - 2e-159 531.6 14.9 2.7e-159 531.2 14.9 1.1 1 0 0 1 1 1 1 Endomembrane protein 70 HAUS5 PF14817.6 ELR19486.1 - 1.6e-18 66.9 16.2 4.1e-17 62.2 2.1 3.1 2 1 1 3 3 3 3 HAUS augmin-like complex subunit 5 BrkDBD PF09607.10 ELR19486.1 - 0.14 12.0 0.6 12 5.8 0.0 2.6 2 0 0 2 2 2 0 Brinker DNA-binding domain Atg14 PF10186.9 ELR19486.1 - 0.99 8.4 3.0 0.49 9.4 0.3 1.8 2 0 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 Ribosomal_L22 PF00237.19 ELR19487.1 - 2.9e-40 136.6 0.2 4.5e-40 136.0 0.2 1.3 1 0 0 1 1 1 1 Ribosomal protein L22p/L17e DUF3592 PF12158.8 ELR19488.1 - 7.9e-06 26.0 0.1 1.7e-05 25.0 0.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3592) Sec7_N PF12783.7 ELR19489.1 - 3.4e-18 66.1 4.6 3.4e-18 66.1 4.6 2.9 2 1 2 4 4 4 1 Guanine nucleotide exchange factor in Golgi transport N-terminal Sec7 PF01369.20 ELR19489.1 - 8.6e-16 58.1 0.0 1.6e-15 57.2 0.0 1.4 1 0 0 1 1 1 1 Sec7 domain DCB PF16213.5 ELR19489.1 - 8.9e-06 25.5 0.1 1.8e-05 24.5 0.1 1.4 1 0 0 1 1 1 1 Dimerisation and cyclophilin-binding domain of Mon2 Dopey_N PF04118.14 ELR19489.1 - 0.034 13.2 2.2 0.39 9.8 1.1 2.1 2 0 0 2 2 2 0 Dopey, N-terminal PAS_9 PF13426.7 ELR19492.1 - 1.1e-25 89.8 0.1 3.9e-20 72.0 0.0 2.9 3 0 0 3 3 3 2 PAS domain PAS_8 PF13188.7 ELR19492.1 - 1e-09 38.2 0.1 8.4e-05 22.5 0.0 3.2 3 0 0 3 3 3 2 PAS domain PAS PF00989.25 ELR19492.1 - 1.1e-07 31.8 0.0 0.0018 18.3 0.0 2.8 2 0 0 2 2 2 2 PAS fold SAM_2 PF07647.17 ELR19492.1 - 7.3e-07 29.2 0.0 1.7e-06 28.0 0.0 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) PAS_4 PF08448.10 ELR19492.1 - 2.2e-06 27.9 0.0 0.061 13.6 0.0 2.9 3 0 0 3 3 3 2 PAS fold PAS_3 PF08447.12 ELR19492.1 - 0.00013 22.2 0.0 0.043 14.1 0.0 2.9 2 1 0 2 2 2 1 PAS fold SAM_1 PF00536.30 ELR19492.1 - 0.001 19.4 0.0 0.0021 18.4 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_3 PF18016.1 ELR19492.1 - 0.018 14.9 0.0 0.04 13.7 0.0 1.6 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) PB1 PF00564.24 ELR19492.1 - 0.072 13.0 0.0 0.16 12.0 0.0 1.6 1 0 0 1 1 1 0 PB1 domain RasGEF PF00617.19 ELR19493.1 - 2e-45 155.2 0.1 4.3e-45 154.1 0.0 1.6 2 0 0 2 2 2 1 RasGEF domain RRP14 PF15459.6 ELR19493.1 - 0.096 13.3 0.3 13 6.4 0.1 2.7 2 0 0 2 2 2 0 60S ribosome biogenesis protein Rrp14 Thioredoxin_8 PF13905.6 ELR19494.1 - 3.5e-25 88.2 0.0 4.4e-25 87.8 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin-like Thioredoxin PF00085.20 ELR19494.1 - 2.5e-07 30.6 0.0 0.00017 21.6 0.0 2.1 2 0 0 2 2 2 2 Thioredoxin Redoxin PF08534.10 ELR19494.1 - 8.2e-06 25.6 0.0 1.2e-05 25.1 0.0 1.2 1 0 0 1 1 1 1 Redoxin Thioredoxin_2 PF13098.6 ELR19494.1 - 0.00061 20.2 0.0 0.0024 18.3 0.0 1.8 1 1 0 1 1 1 1 Thioredoxin-like domain AhpC-TSA PF00578.21 ELR19494.1 - 0.0018 18.2 0.0 0.0034 17.3 0.0 1.4 1 1 0 1 1 1 1 AhpC/TSA family Thioredoxin_9 PF14595.6 ELR19494.1 - 0.23 11.2 0.1 25 4.7 0.1 2.5 2 1 1 3 3 3 0 Thioredoxin Pkinase_Tyr PF07714.17 ELR19495.1 - 1.7e-52 178.3 0.0 4.1e-51 173.8 0.0 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase MORN PF02493.20 ELR19495.1 - 2.2e-45 149.9 47.0 3.8e-08 32.8 1.9 8.7 8 0 0 8 8 8 8 MORN repeat Pkinase PF00069.25 ELR19495.1 - 4.3e-26 91.9 0.0 8.6e-25 87.6 0.0 2.1 1 1 0 1 1 1 1 Protein kinase domain SAM_1 PF00536.30 ELR19495.1 - 1.6e-05 25.2 0.0 4.6e-05 23.8 0.0 1.8 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 ELR19495.1 - 5.1e-05 23.3 0.0 0.00012 22.2 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) HEAT PF02985.22 ELR19496.1 - 1.8e-06 27.7 4.6 0.053 13.8 0.4 6.2 5 0 0 5 5 5 2 HEAT repeat MMS19_C PF12460.8 ELR19496.1 - 0.034 13.3 0.2 2.1 7.3 0.3 3.1 2 0 0 2 2 2 0 RNAPII transcription regulator C-terminal Ribosomal_S9 PF00380.19 ELR19497.1 - 6.4e-33 113.8 0.1 7.4e-33 113.6 0.1 1.0 1 0 0 1 1 1 1 Ribosomal protein S9/S16 ADK PF00406.22 ELR19498.1 - 2.1e-08 34.4 0.4 4.8e-07 30.0 0.4 2.2 1 1 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 ELR19498.1 - 0.00088 19.7 0.0 0.0029 18.0 0.0 1.8 1 1 0 1 1 1 1 AAA domain Viral_DNA_bi PF02236.17 ELR19498.1 - 0.14 12.4 0.0 0.24 11.6 0.0 1.3 1 0 0 1 1 1 0 Viral DNA-binding protein, all alpha domain EF1G PF00647.19 ELR19500.1 - 2.1e-46 156.3 0.1 4.6e-46 155.3 0.1 1.6 1 0 0 1 1 1 1 Elongation factor 1 gamma, conserved domain GST_N PF02798.20 ELR19500.1 - 1.4e-14 54.2 0.0 3.5e-14 52.9 0.0 1.8 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 ELR19500.1 - 2.4e-13 50.1 0.0 4.9e-13 49.1 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 ELR19500.1 - 5.5e-11 42.3 0.0 1.8e-10 40.6 0.0 1.8 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 ELR19500.1 - 2.6e-07 30.9 0.0 8.5e-07 29.3 0.0 1.8 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 ELR19500.1 - 4e-05 23.7 0.0 0.0001 22.5 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.6 ELR19500.1 - 0.0062 16.8 0.0 0.013 15.8 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain Transket_pyr PF02779.24 ELR19501.1 - 3.2e-64 215.9 0.0 5.3e-64 215.2 0.0 1.4 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain E1_dh PF00676.20 ELR19501.1 - 1.4e-58 198.3 0.0 2e-58 197.7 0.0 1.2 1 0 0 1 1 1 1 Dehydrogenase E1 component OxoGdeHyase_C PF16870.5 ELR19501.1 - 3.1e-50 169.8 0.0 6e-50 168.9 0.0 1.5 1 0 0 1 1 1 1 2-oxoglutarate dehydrogenase C-terminal 2-oxogl_dehyd_N PF16078.5 ELR19501.1 - 4.9e-16 58.0 0.6 1.2e-15 56.8 0.6 1.7 1 0 0 1 1 1 1 2-oxoglutarate dehydrogenase N-terminus Sterile PF03015.19 ELR19501.1 - 0.018 15.2 0.3 0.05 13.8 0.1 1.8 2 0 0 2 2 2 0 Male sterility protein PWI PF01480.17 ELR19502.1 - 2.7e-26 91.7 0.0 4.4e-26 91.0 0.0 1.4 1 0 0 1 1 1 1 PWI domain DUF3439 PF11921.8 ELR19502.1 - 0.057 13.4 0.7 0.1 12.6 0.7 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) DUF4683 PF15735.5 ELR19503.1 - 0.16 11.6 14.1 0.23 11.1 14.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4683) IFT46_B_C PF12317.8 ELR19503.1 - 0.45 10.2 1.3 0.7 9.6 1.3 1.3 1 0 0 1 1 1 0 Intraflagellar transport complex B protein 46 C terminal Apt1 PF10351.9 ELR19503.1 - 1.4 7.7 12.7 2.5 6.9 12.7 1.4 1 0 0 1 1 1 0 Golgi-body localisation protein domain DUF572 PF04502.13 ELR19503.1 - 1.9 8.1 15.5 3.1 7.4 15.5 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF572) DUF3246 PF11596.8 ELR19503.1 - 2 7.8 15.8 0.68 9.3 1.3 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3246) Peptidase_S64 PF08192.11 ELR19503.1 - 4.5 5.6 11.7 5.9 5.2 11.7 1.1 1 0 0 1 1 1 0 Peptidase family S64 DUF2956 PF11169.8 ELR19503.1 - 5.6 7.2 12.2 0.24 11.6 0.5 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF2956) RhoGAP PF00620.27 ELR19504.1 - 9.7e-34 116.4 0.0 9.7e-34 116.4 0.0 2.7 3 0 0 3 3 3 1 RhoGAP domain FYVE PF01363.21 ELR19504.1 - 5.5e-06 26.4 4.8 1.2e-05 25.3 4.8 1.5 1 0 0 1 1 1 1 FYVE zinc finger LRR_8 PF13855.6 ELR19504.1 - 6.6e-05 22.6 4.0 0.00015 21.4 4.0 1.5 1 0 0 1 1 1 1 Leucine rich repeat LRR_4 PF12799.7 ELR19504.1 - 0.00021 21.6 3.6 0.0006 20.1 3.6 1.8 1 0 0 1 1 1 1 Leucine Rich repeats (2 copies) DUF812 PF05667.11 ELR19504.1 - 0.0045 16.0 0.7 0.0045 16.0 0.7 6.1 3 2 1 5 5 5 1 Protein of unknown function (DUF812) NPV_P10 PF05531.12 ELR19504.1 - 1.5 9.3 11.6 9.3 6.8 0.1 4.5 4 1 1 5 5 5 0 Nucleopolyhedrovirus P10 protein BRICHOS PF04089.14 ELR19504.1 - 9.1 6.6 9.6 0.44 10.8 0.3 3.7 3 0 0 3 3 3 0 BRICHOS domain Ras PF00071.22 ELR19505.1 - 1.6e-37 128.6 0.0 3.6e-37 127.5 0.0 1.5 1 1 0 1 1 1 1 Ras family Roc PF08477.13 ELR19505.1 - 5.8e-27 94.3 0.0 7.9e-27 93.9 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR19505.1 - 3.8e-09 36.2 0.0 4.2e-09 36.1 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 ELR19505.1 - 0.017 15.2 0.0 0.025 14.7 0.0 1.3 1 0 0 1 1 1 0 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 ELR19505.1 - 0.024 14.5 0.0 0.73 9.7 0.0 2.1 2 0 0 2 2 2 0 RsgA GTPase Gtr1_RagA PF04670.12 ELR19505.1 - 0.097 12.0 0.0 0.18 11.2 0.0 1.6 1 1 0 1 1 1 0 Gtr1/RagA G protein conserved region SRPRB PF09439.10 ELR19505.1 - 0.11 11.9 0.0 0.15 11.5 0.0 1.2 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit SpoIIE PF07228.12 ELR19506.1 - 6.5e-18 65.3 0.4 9.5e-18 64.8 0.4 1.2 1 0 0 1 1 1 1 Stage II sporulation protein E (SpoIIE) PP2C PF00481.21 ELR19506.1 - 4.7e-12 46.1 0.2 7.6e-07 29.0 0.0 2.2 2 0 0 2 2 2 2 Protein phosphatase 2C PP2C_2 PF13672.6 ELR19506.1 - 3.3e-05 23.6 0.5 6.5e-05 22.7 0.5 1.4 1 0 0 1 1 1 1 Protein phosphatase 2C Methyltrans_RNA PF04452.14 ELR19507.1 - 3.3e-42 144.4 0.2 9.5e-20 70.9 0.0 3.1 2 1 1 3 3 3 3 RNA methyltransferase Vps62 PF06101.11 ELR19508.1 - 1.9e-16 59.5 0.0 2.4e-16 59.2 0.0 1.1 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 62 zf-C3HC4_3 PF13920.6 ELR19508.1 - 1.3e-08 34.5 8.4 1.3e-08 34.5 8.4 2.7 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 ELR19508.1 - 1.4e-07 31.7 10.6 1.4e-07 31.7 10.6 3.3 3 0 0 3 3 3 1 Ring finger domain zf-C3HC4 PF00097.25 ELR19508.1 - 5.3e-07 29.4 8.1 5.3e-07 29.4 8.1 2.9 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 ELR19508.1 - 3.5e-06 26.8 9.3 3.5e-06 26.8 9.3 2.6 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 ELR19508.1 - 0.00069 19.7 7.9 0.00069 19.7 7.9 2.5 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-TRAF PF02176.18 ELR19508.1 - 0.014 16.1 1.3 0.014 16.1 1.3 3.1 3 0 0 3 3 3 0 TRAF-type zinc finger zf-RING_6 PF14835.6 ELR19508.1 - 0.015 15.1 5.2 0.015 15.1 5.2 1.9 2 0 0 2 2 2 0 zf-RING of BARD1-type protein zf-RING_UBOX PF13445.6 ELR19508.1 - 0.026 14.6 9.0 0.026 14.6 9.0 2.5 2 0 0 2 2 2 0 RING-type zinc-finger Sina PF03145.16 ELR19508.1 - 3.3 7.6 5.5 0.63 9.9 1.6 1.8 2 0 0 2 2 2 0 Seven in absentia protein family zf-Nse PF11789.8 ELR19508.1 - 9.5 6.1 10.4 0.12 12.2 2.5 1.9 2 0 0 2 2 1 0 Zinc-finger of the MIZ type in Nse subunit zf-C3HC4_2 PF13923.6 ELR19510.1 - 0.00019 21.2 2.6 0.00085 19.1 2.6 2.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 ELR19510.1 - 0.00038 20.3 2.2 0.0011 18.7 2.2 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 ELR19510.1 - 0.00056 20.2 6.6 0.00094 19.5 4.7 2.4 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_3 PF13920.6 ELR19510.1 - 0.0011 18.8 3.0 0.0026 17.6 3.0 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) DUF4428 PF14471.6 ELR19510.1 - 0.0093 15.9 1.4 0.019 14.9 1.4 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4428) zf-RING_UBOX PF13445.6 ELR19510.1 - 0.011 15.8 1.9 0.029 14.4 1.9 1.8 1 0 0 1 1 1 0 RING-type zinc-finger zf-RING_11 PF17123.5 ELR19510.1 - 0.016 14.9 0.5 0.051 13.3 0.5 1.9 1 0 0 1 1 1 0 RING-like zinc finger zf-RING_5 PF14634.6 ELR19510.1 - 0.029 14.3 3.9 0.092 12.7 3.9 1.9 1 1 0 1 1 1 0 zinc-RING finger domain Prok-RING_4 PF14447.6 ELR19510.1 - 0.036 13.9 2.3 0.13 12.2 2.3 2.0 1 1 0 1 1 1 0 Prokaryotic RING finger family 4 zf-HC5HC2H PF13771.6 ELR19510.1 - 0.08 13.2 2.6 0.18 12.1 2.6 1.7 1 0 0 1 1 1 0 PHD-like zinc-binding domain eIF2_C PF09173.11 ELR19511.1 - 1.8e-20 73.0 0.1 3e-20 72.2 0.1 1.4 1 0 0 1 1 1 1 Initiation factor eIF2 gamma, C terminal GTP_EFTU PF00009.27 ELR19511.1 - 6.9e-10 38.8 0.0 1e-09 38.3 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D2 PF03144.25 ELR19511.1 - 1e-06 29.1 0.1 2.3e-06 27.9 0.1 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1_Xtn PF16897.5 ELR19511.1 - 0.17 11.9 0.0 0.34 10.9 0.0 1.5 1 0 0 1 1 1 0 C-terminal region of MMR_HSR1 domain GTP_EFTU PF00009.27 ELR19512.1 - 1.4e-09 37.8 0.0 2.4e-09 37.0 0.0 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 ELR19512.1 - 0.00084 19.4 0.0 0.0014 18.7 0.0 1.3 1 1 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_N PF00350.23 ELR19512.1 - 0.094 12.8 0.1 0.45 10.6 0.1 1.9 1 1 0 2 2 2 0 Dynamin family DUF674 PF05056.12 ELR19512.1 - 0.13 11.1 1.1 0.16 10.8 1.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF674) GATase_6 PF13522.6 ELR19513.1 - 6.9e-15 55.4 0.0 2.1e-14 53.9 0.0 1.7 2 0 0 2 2 2 1 Glutamine amidotransferase domain GATase_7 PF13537.6 ELR19513.1 - 1e-13 51.3 0.0 3.3e-13 49.6 0.0 1.9 2 0 0 2 2 2 1 Glutamine amidotransferase domain Pribosyltran PF00156.27 ELR19513.1 - 3.5e-06 26.6 0.0 6.1e-06 25.8 0.0 1.3 1 0 0 1 1 1 1 Phosphoribosyl transferase domain GATase_4 PF13230.6 ELR19513.1 - 7.2e-06 25.1 0.0 1.2e-05 24.4 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferases class-II PRTase_2 PF15609.6 ELR19513.1 - 0.019 14.5 0.0 0.039 13.4 0.0 1.4 1 0 0 1 1 1 0 Phosphoribosyl transferase GATase_5 PF13507.6 ELR19514.1 - 2.5e-105 351.2 0.0 4.2e-105 350.5 0.0 1.4 1 0 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain AIRS_C PF02769.22 ELR19514.1 - 1.3e-31 109.9 4.1 3.7e-15 56.4 0.5 2.4 2 0 0 2 2 2 2 AIR synthase related protein, C-terminal domain FGAR-AT_N PF18076.1 ELR19514.1 - 2.6e-17 62.9 0.0 5.5e-17 61.8 0.0 1.5 1 0 0 1 1 1 1 Formylglycinamide ribonucleotide amidotransferase N-terminal FGAR-AT_linker PF18072.1 ELR19514.1 - 7.6e-12 45.6 0.1 2.7e-11 43.8 0.1 2.0 1 0 0 1 1 1 1 Formylglycinamide ribonucleotide amidotransferase linker domain Abhydrolase_6 PF12697.7 ELR19518.1 - 2.8e-13 51.0 0.4 4.2e-13 50.4 0.4 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 ELR19518.1 - 7.4e-13 48.7 0.0 5.1e-12 46.0 0.1 1.9 1 1 1 2 2 2 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 ELR19518.1 - 8.1e-09 35.1 0.0 1.8e-08 33.9 0.0 1.6 1 1 0 1 1 1 1 Serine aminopeptidase, S33 PGAP1 PF07819.13 ELR19518.1 - 0.033 13.9 0.0 0.052 13.3 0.0 1.4 1 0 0 1 1 1 0 PGAP1-like protein Esterase PF00756.20 ELR19518.1 - 0.056 13.1 0.8 0.72 9.5 0.0 2.1 1 1 0 2 2 2 0 Putative esterase Thioesterase PF00975.20 ELR19518.1 - 0.073 13.2 0.3 0.24 11.5 0.0 1.9 2 0 0 2 2 2 0 Thioesterase domain PH PF00169.29 ELR19520.1 - 2.2e-14 53.9 2.1 1.7e-09 38.1 0.0 2.7 2 1 0 2 2 2 2 PH domain FHA PF00498.26 ELR19520.1 - 4.8e-12 46.0 0.2 1.1e-11 44.9 0.2 1.7 1 0 0 1 1 1 1 FHA domain Yop-YscD_cpl PF16697.5 ELR19520.1 - 7.2e-12 45.5 0.1 1.5e-11 44.4 0.1 1.5 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain PH_11 PF15413.6 ELR19520.1 - 9.1e-05 22.8 5.6 0.0087 16.5 1.3 3.1 2 1 0 2 2 2 2 Pleckstrin homology domain PH_8 PF15409.6 ELR19520.1 - 0.037 14.3 0.2 0.56 10.5 0.0 2.6 2 0 0 2 2 2 0 Pleckstrin homology domain PH_17 PF18012.1 ELR19520.1 - 0.095 12.4 0.0 0.27 11.0 0.0 1.8 2 0 0 2 2 2 0 PH domain ATG101 PF07855.12 ELR19521.1 - 5e-32 111.0 4.1 5.6e-32 110.9 4.1 1.0 1 0 0 1 1 1 1 Autophagy-related protein 101 ATG101 PF07855.12 ELR19523.1 - 3e-38 131.2 4.6 4e-38 130.8 4.6 1.1 1 0 0 1 1 1 1 Autophagy-related protein 101 Swi3 PF07962.12 ELR19524.1 - 1.1e-12 47.7 0.0 3.3e-12 46.2 0.0 1.7 1 0 0 1 1 1 1 Replication Fork Protection Component Swi3 TPR_2 PF07719.17 ELR19525.1 - 7.2e-07 28.9 9.2 0.055 13.6 0.1 6.3 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_16 PF13432.6 ELR19525.1 - 6.9e-06 26.6 6.6 0.033 14.8 0.0 4.7 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_14 PF13428.6 ELR19525.1 - 2.2e-05 24.9 11.5 0.16 12.9 0.2 6.1 4 2 2 6 6 6 1 Tetratricopeptide repeat TPR_19 PF14559.6 ELR19525.1 - 6.7e-05 23.3 6.6 0.027 15.0 0.0 4.7 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_12 PF13424.6 ELR19525.1 - 0.00024 21.3 6.0 2 8.7 0.1 4.6 4 1 1 5 5 5 2 Tetratricopeptide repeat TPR_1 PF00515.28 ELR19525.1 - 0.00044 19.9 0.1 2.8 7.9 0.1 4.8 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_11 PF13414.6 ELR19525.1 - 0.0012 18.5 0.5 0.0038 16.9 0.1 2.1 2 0 0 2 2 2 1 TPR repeat TPR_8 PF13181.6 ELR19525.1 - 0.036 14.3 5.4 25 5.4 0.0 5.2 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_4 PF07721.14 ELR19525.1 - 0.12 13.0 13.5 11 7.0 0.1 5.4 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_10 PF13374.6 ELR19525.1 - 1.5 8.8 4.8 22 5.1 0.2 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat OMPdecase PF00215.24 ELR19526.1 - 3.9e-58 196.7 0.2 3.9e-58 196.7 0.2 1.9 2 0 0 2 2 2 1 Orotidine 5'-phosphate decarboxylase / HUMPS family Pribosyltran PF00156.27 ELR19526.1 - 2.4e-11 43.4 0.1 5.1e-11 42.3 0.1 1.5 1 0 0 1 1 1 1 Phosphoribosyl transferase domain DUF4142 PF13628.6 ELR19526.1 - 0.008 16.4 3.9 0.0097 16.1 2.0 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF4142) DJ-1_PfpI PF01965.24 ELR19528.1 - 9.5e-43 145.9 0.0 1.1e-42 145.6 0.0 1.1 1 0 0 1 1 1 1 DJ-1/PfpI family GATase PF00117.28 ELR19528.1 - 0.018 14.8 0.0 0.023 14.5 0.0 1.2 1 0 0 1 1 1 0 Glutamine amidotransferase class-I DNA_Packaging_2 PF11123.8 ELR19528.1 - 0.045 14.0 0.0 0.098 12.9 0.0 1.5 1 0 0 1 1 1 0 DNA packaging protein WD40 PF00400.32 ELR19529.1 - 5.5e-17 61.8 6.6 9e-06 26.3 0.2 5.4 6 0 0 6 6 6 4 WD domain, G-beta repeat EF-hand_7 PF13499.6 ELR19530.1 - 3.7e-27 94.6 7.8 1e-12 48.3 0.1 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 ELR19530.1 - 1.1e-26 90.3 9.5 9.5e-06 24.8 0.9 4.2 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.6 ELR19530.1 - 9.6e-26 87.5 7.8 5.2e-07 29.1 0.0 4.3 4 0 0 4 4 4 4 EF-hand domain EF-hand_8 PF13833.6 ELR19530.1 - 1.2e-25 89.1 9.3 7e-06 25.8 0.0 4.1 2 2 2 4 4 4 4 EF-hand domain pair EF-hand_5 PF13202.6 ELR19530.1 - 9.4e-23 78.7 12.9 2.1e-05 23.8 0.2 4.3 4 0 0 4 4 4 4 EF hand SPARC_Ca_bdg PF10591.9 ELR19530.1 - 3.6e-08 33.7 0.5 0.0051 17.1 0.1 3.1 2 1 1 3 3 3 3 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 ELR19530.1 - 5.5e-05 23.1 8.6 0.16 11.9 0.3 4.0 2 2 2 4 4 4 2 Cytoskeletal-regulatory complex EF hand TerB PF05099.13 ELR19530.1 - 0.00038 20.4 0.1 0.14 12.1 0.0 2.1 1 1 1 2 2 2 2 Tellurite resistance protein TerB Caleosin PF05042.13 ELR19530.1 - 0.021 14.7 3.3 2.4 8.0 1.1 3.3 1 1 0 2 2 2 0 Caleosin related protein PTPS PF01242.19 ELR19530.1 - 0.035 14.1 0.0 0.13 12.3 0.0 1.8 2 0 0 2 2 2 0 6-pyruvoyl tetrahydropterin synthase Cbl_N2 PF02761.14 ELR19530.1 - 0.1 13.4 0.4 0.59 10.9 0.1 2.0 2 0 0 2 2 2 0 CBL proto-oncogene N-terminus, EF hand-like domain EF-hand_9 PF14658.6 ELR19530.1 - 0.13 12.6 0.3 5.1 7.5 0.0 2.8 2 2 0 2 2 2 0 EF-hand domain Herpes_UL33 PF03581.13 ELR19530.1 - 0.2 12.0 0.0 14 6.2 0.0 2.3 2 0 0 2 2 2 0 Herpesvirus UL33-like protein EF-hand_10 PF14788.6 ELR19530.1 - 0.28 11.1 1.8 21 5.1 0.0 2.6 3 0 0 3 3 3 0 EF hand Metallophos PF00149.28 ELR19531.1 - 2.6e-09 37.9 0.0 7.2e-09 36.4 0.0 1.7 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 ELR19531.1 - 1.9e-06 28.2 0.0 9.3e-06 25.9 0.0 2.1 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain DUF719 PF05334.13 ELR19531.1 - 4.4e-05 23.8 0.3 9.1e-05 22.7 0.3 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF719) CDC45 PF02724.14 ELR19531.1 - 0.13 10.6 4.0 0.17 10.2 4.0 1.1 1 0 0 1 1 1 0 CDC45-like protein Mlh1_C PF16413.5 ELR19531.1 - 0.13 11.6 2.2 0.14 11.5 1.3 1.4 2 0 0 2 2 2 0 DNA mismatch repair protein Mlh1 C-terminus RAB3GAP2_C PF14656.6 ELR19531.1 - 0.37 9.0 2.8 0.53 8.5 2.8 1.1 1 0 0 1 1 1 0 Rab3 GTPase-activating protein regulatory subunit C-terminus Connexin PF00029.19 ELR19531.1 - 0.45 10.2 1.6 0.71 9.6 1.6 1.2 1 0 0 1 1 1 0 Connexin DNA_pol_phi PF04931.13 ELR19531.1 - 0.54 8.3 7.3 0.8 7.7 7.3 1.1 1 0 0 1 1 1 0 DNA polymerase phi THOC2_N PF16134.5 ELR19531.1 - 1.1 7.8 3.5 1.6 7.3 3.5 1.1 1 0 0 1 1 1 0 THO complex subunit 2 N-terminus FAM176 PF14851.6 ELR19531.1 - 1.6 8.3 7.1 2.9 7.5 7.1 1.3 1 0 0 1 1 1 0 FAM176 family RNA_pol_Rpc4 PF05132.14 ELR19531.1 - 2.6 8.5 7.8 6 7.3 4.1 2.2 2 0 0 2 2 2 0 RNA polymerase III RPC4 NOA36 PF06524.12 ELR19531.1 - 3 7.1 8.8 4.9 6.4 8.8 1.2 1 0 0 1 1 1 0 NOA36 protein TRAP_alpha PF03896.16 ELR19531.1 - 5.6 6.1 5.8 8 5.6 5.8 1.1 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit PfkB PF00294.24 ELR19532.1 - 1.6e-05 24.4 0.0 0.16 11.2 0.0 2.4 1 1 1 2 2 2 2 pfkB family carbohydrate kinase DUF953 PF06110.11 ELR19533.1 - 1.9e-21 75.9 0.0 2.7e-21 75.4 0.0 1.2 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF953) Glutaredoxin PF00462.24 ELR19533.1 - 0.87 9.8 0.1 0.87 9.8 0.1 2.2 2 2 0 2 2 2 0 Glutaredoxin Hexapep PF00132.24 ELR19534.1 - 2.5e-09 36.5 28.3 8.6e-05 22.1 0.4 9.0 7 2 3 10 10 10 6 Bacterial transferase hexapeptide (six repeats) CRT-like PF08627.10 ELR19537.1 - 2.9e-99 332.2 16.5 3.7e-99 331.8 16.5 1.1 1 0 0 1 1 1 1 CRT-like, chloroquine-resistance transporter-like SLC35F PF06027.12 ELR19537.1 - 8.7e-06 25.5 5.6 8.7e-06 25.5 5.6 2.2 2 0 0 2 2 2 1 Solute carrier family 35 PIG-S PF10510.9 ELR19537.1 - 0.24 10.2 0.5 0.36 9.6 0.5 1.1 1 0 0 1 1 1 0 Phosphatidylinositol-glycan biosynthesis class S protein zf-CHY PF05495.12 ELR19538.1 - 1.7e-16 60.4 20.7 1.7e-16 60.4 20.7 2.2 2 0 0 2 2 2 1 CHY zinc finger F-box-like PF12937.7 ELR19538.1 - 6.1e-06 26.0 0.4 1.5e-05 24.8 0.0 1.9 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 ELR19538.1 - 2.5e-05 24.0 0.0 7e-05 22.6 0.0 1.8 1 0 0 1 1 1 1 F-box domain Cut12 PF11500.8 ELR19538.1 - 0.12 12.3 0.0 0.2 11.6 0.0 1.3 1 0 0 1 1 1 0 Spindle pole body formation-associated protein Ephrin_rec_like PF07699.13 ELR19539.1 - 7.3e-05 22.5 23.8 0.015 15.1 3.1 3.5 1 1 3 4 4 4 4 Putative ephrin-receptor like TNFR_c6 PF00020.18 ELR19539.1 - 0.017 15.5 2.6 0.017 15.5 2.6 4.6 1 1 1 2 2 2 0 TNFR/NGFR cysteine-rich region Lipoprotein_15 PF03640.15 ELR19540.1 - 0.004 16.7 0.1 0.007 15.9 0.1 1.4 1 0 0 1 1 1 1 Secreted repeat of unknown function DPM3 PF08285.11 ELR19540.1 - 5.2 7.3 6.7 92 3.3 6.7 2.5 1 1 0 1 1 1 0 Dolichol-phosphate mannosyltransferase subunit 3 (DPM3) AMP-binding PF00501.28 ELR19541.1 - 9e-73 245.3 0.0 1.6e-72 244.5 0.0 1.3 1 0 0 1 1 1 1 AMP-binding enzyme NAD_binding_4 PF07993.12 ELR19541.1 - 8.4e-35 120.2 1.3 1.7e-33 115.9 0.0 2.8 1 1 1 2 2 2 1 Male sterility protein AMP-binding_C PF13193.6 ELR19541.1 - 5.4e-06 27.3 0.0 1.6e-05 25.7 0.0 1.9 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain PP-binding PF00550.25 ELR19541.1 - 0.00026 21.3 0.1 0.00084 19.6 0.0 2.0 2 0 0 2 2 2 1 Phosphopantetheine attachment site Epimerase PF01370.21 ELR19541.1 - 0.0004 19.9 0.0 0.00087 18.8 0.0 1.6 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Fascin PF06268.13 ELR19542.1 - 5.1e-13 49.2 0.4 2.9e-09 37.1 0.1 2.1 1 1 1 2 2 2 2 Fascin domain FRG1 PF06229.12 ELR19542.1 - 3.3e-09 36.7 0.0 0.00074 19.3 0.0 2.3 1 1 1 2 2 2 2 FRG1-like domain DUF569 PF04601.13 ELR19542.1 - 7.3e-08 32.2 0.0 0.00074 19.2 0.0 2.2 2 0 0 2 2 2 2 Domain of unknown function (DUF569) FGF PF00167.18 ELR19542.1 - 0.00034 20.7 0.0 0.0023 18.0 0.0 1.9 1 1 1 2 2 2 1 Fibroblast growth factor VWA PF00092.28 ELR19543.1 - 3.3e-18 66.5 0.0 2.6e-16 60.4 0.0 2.5 2 0 0 2 2 2 1 von Willebrand factor type A domain VWA_2 PF13519.6 ELR19543.1 - 1.6e-15 57.7 0.3 5.1e-15 56.0 0.0 2.0 2 0 0 2 2 2 1 von Willebrand factor type A domain VWA_3 PF13768.6 ELR19543.1 - 1.1e-09 38.4 0.0 1.8e-05 24.7 0.1 2.5 2 0 0 2 2 2 2 von Willebrand factor type A domain Vwaint PF14624.6 ELR19543.1 - 0.00089 19.3 3.4 0.0015 18.6 3.4 1.4 1 0 0 1 1 1 1 VWA / Hh protein intein-like DUF2201 PF09967.9 ELR19543.1 - 0.014 15.5 0.1 0.035 14.2 0.1 1.7 1 0 0 1 1 1 0 VWA-like domain (DUF2201) DUF444 PF04285.12 ELR19543.1 - 0.18 10.9 0.1 0.18 10.9 0.1 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF444) Glyco_transf_4 PF13439.6 ELR19544.1 - 1.8e-09 37.8 1.4 3.2e-09 37.0 1.4 1.3 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glycos_transf_1 PF00534.20 ELR19544.1 - 2.2e-08 33.8 0.0 3.9e-08 33.0 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.6 ELR19544.1 - 1.1e-07 32.4 0.1 2e-07 31.6 0.1 1.4 1 0 0 1 1 1 1 Glycosyl transferase 4-like domain Glyco_trans_1_4 PF13692.6 ELR19544.1 - 1.4e-06 28.8 0.0 3.1e-06 27.7 0.0 1.6 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glyco_trans_1_2 PF13524.6 ELR19544.1 - 0.17 12.3 0.0 0.39 11.2 0.0 1.6 1 0 0 1 1 1 0 Glycosyl transferases group 1 CbbQ_C PF08406.10 ELR19545.1 - 1.8 8.9 7.9 1.7e+02 2.6 0.1 5.1 4 2 2 6 6 6 0 CbbQ/NirQ/NorQ C-terminal FYVE PF01363.21 ELR19546.1 - 1.5e-17 63.4 9.0 2.4e-17 62.8 9.0 1.3 1 0 0 1 1 1 1 FYVE zinc finger Glyco_transf_28 PF03033.20 ELR19546.1 - 7.2e-10 39.0 0.0 1.4e-09 38.1 0.0 1.5 1 0 0 1 1 1 1 Glycosyltransferase family 28 N-terminal domain UDPGT PF00201.18 ELR19546.1 - 1.9e-05 23.7 0.0 2.7e-05 23.2 0.0 1.2 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.16 ELR19546.1 - 3e-05 24.0 0.0 5.9e-05 23.1 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain FYVE_2 PF02318.16 ELR19546.1 - 0.069 13.4 6.7 0.11 12.7 6.7 1.3 1 0 0 1 1 1 0 FYVE-type zinc finger Glyco_transf_4 PF13439.6 ELR19546.1 - 0.17 11.8 0.4 0.89 9.5 0.0 2.3 2 1 0 2 2 2 0 Glycosyltransferase Family 4 IBR PF01485.21 ELR19546.1 - 0.18 12.0 2.5 0.4 10.9 2.5 1.5 1 0 0 1 1 1 0 IBR domain, a half RING-finger domain XPA_N PF01286.18 ELR19546.1 - 1.8 8.7 5.4 2.2 8.4 1.4 2.3 2 0 0 2 2 2 0 XPA protein N-terminal zf-RING_2 PF13639.6 ELR19546.1 - 5.4 7.4 10.5 9.8 6.6 10.5 1.5 1 0 0 1 1 1 0 Ring finger domain SR-25 PF10500.9 ELR19547.1 - 0.046 13.3 4.6 0.054 13.1 4.6 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Exo_endo_phos PF03372.23 ELR19547.1 - 0.087 12.3 3.8 0.22 11.0 3.8 1.7 1 1 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family IMUP PF15761.5 ELR19547.1 - 0.32 11.7 4.4 0.43 11.3 4.4 1.2 1 0 0 1 1 1 0 Immortalisation up-regulated protein DUF755 PF05501.11 ELR19547.1 - 7 6.9 12.4 9.4 6.5 12.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF755) Exo_endo_phos PF03372.23 ELR19548.1 - 2.9e-09 36.8 0.1 4.7e-09 36.1 0.1 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family SOG2 PF10428.9 ELR19549.1 - 0.00021 20.7 29.7 0.00021 20.7 29.7 2.8 3 0 0 3 3 3 1 RAM signalling pathway protein DC_STAMP PF07782.13 ELR19549.1 - 0.27 11.0 3.1 0.2 11.4 0.4 2.1 1 1 0 2 2 2 0 DC-STAMP-like protein Tmpp129 PF10272.9 ELR19549.1 - 0.92 8.7 2.9 1.6 8.0 2.5 1.5 1 1 0 1 1 1 0 Putative transmembrane protein precursor Mor PF08765.11 ELR19549.1 - 8.6 6.4 11.3 42 4.2 1.2 4.5 1 1 3 4 4 4 0 Mor transcription activator family DAO PF01266.24 ELR19550.1 - 4.8e-49 167.8 0.0 5.7e-49 167.6 0.0 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 ELR19550.1 - 5.4e-08 32.4 0.1 0.00093 18.5 0.2 2.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 ELR19550.1 - 2.8e-06 26.8 2.6 0.0008 18.7 1.3 2.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 ELR19550.1 - 0.00038 21.0 0.7 0.0055 17.2 0.4 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 ELR19550.1 - 0.00042 20.5 0.1 0.0012 19.0 0.1 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain 3HCDH_N PF02737.18 ELR19550.1 - 0.0095 15.8 0.0 0.026 14.4 0.1 1.7 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Lycopene_cycl PF05834.12 ELR19550.1 - 0.015 14.4 0.3 4.6 6.2 0.1 2.1 2 0 0 2 2 2 0 Lycopene cyclase protein ApbA PF02558.16 ELR19550.1 - 0.029 14.0 0.0 0.056 13.1 0.0 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA NAD_binding_7 PF13241.6 ELR19550.1 - 0.032 14.7 0.1 0.3 11.5 0.1 2.1 2 0 0 2 2 2 0 Putative NAD(P)-binding TrkA_N PF02254.18 ELR19550.1 - 0.034 14.4 0.1 0.062 13.6 0.1 1.4 1 0 0 1 1 1 0 TrkA-N domain F420_oxidored PF03807.17 ELR19550.1 - 0.036 14.7 0.1 0.072 13.7 0.1 1.5 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent GMC_oxred_N PF00732.19 ELR19550.1 - 0.038 13.4 0.1 0.14 11.5 0.0 1.8 2 0 0 2 2 2 0 GMC oxidoreductase adh_short PF00106.25 ELR19550.1 - 0.04 13.4 0.0 0.81 9.1 0.1 2.3 2 0 0 2 2 2 0 short chain dehydrogenase FAD_binding_2 PF00890.24 ELR19550.1 - 0.072 12.2 0.0 0.097 11.7 0.0 1.2 1 0 0 1 1 1 0 FAD binding domain PD40 PF07676.12 ELR19550.1 - 0.091 12.7 0.1 0.38 10.7 0.1 2.1 2 0 0 2 2 2 0 WD40-like Beta Propeller Repeat HI0933_like PF03486.14 ELR19550.1 - 0.15 10.7 2.0 4.1 6.0 0.6 2.2 2 0 0 2 2 2 0 HI0933-like protein Sacchrp_dh_NADP PF03435.18 ELR19550.1 - 0.16 12.2 0.2 0.37 11.1 0.2 1.6 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain Shikimate_DH PF01488.20 ELR19550.1 - 0.16 12.0 0.0 0.36 10.9 0.0 1.5 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Lyase_1 PF00206.20 ELR19551.1 - 2.8e-46 158.4 0.0 4.8e-46 157.6 0.0 1.3 1 0 0 1 1 1 1 Lyase ASL_C PF08328.11 ELR19551.1 - 1.8e-45 153.7 1.0 2.5e-45 153.3 0.1 1.7 2 0 0 2 2 2 1 Adenylosuccinate lyase C-terminal EF-hand_5 PF13202.6 ELR19552.1 - 2.8e-05 23.4 0.0 6.6e-05 22.2 0.0 1.6 1 0 0 1 1 1 1 EF hand EF-hand_1 PF00036.32 ELR19552.1 - 0.0066 15.9 0.0 0.016 14.7 0.0 1.7 1 0 0 1 1 1 1 EF hand M20_dimer PF07687.14 ELR19552.1 - 0.045 13.7 1.3 0.2 11.6 0.5 2.1 1 1 1 2 2 2 0 Peptidase dimerisation domain EF-hand_8 PF13833.6 ELR19552.1 - 0.075 12.9 0.1 0.21 11.5 0.0 1.7 2 0 0 2 2 2 0 EF-hand domain pair EF-hand_6 PF13405.6 ELR19552.1 - 0.11 12.4 0.0 0.31 11.1 0.0 1.7 1 0 0 1 1 1 0 EF-hand domain VCBS PF13517.6 ELR19552.1 - 0.19 12.4 0.9 0.4 11.3 0.9 1.7 1 1 0 1 1 1 0 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella Patatin PF01734.22 ELR19553.1 - 1.8e-07 31.6 0.8 1.8e-07 31.6 0.8 3.3 2 2 0 3 3 3 1 Patatin-like phospholipase PH PF00169.29 ELR19553.1 - 0.00059 20.3 0.6 0.0019 18.7 0.6 1.9 1 0 0 1 1 1 1 PH domain CBM49 PF09478.10 ELR19554.1 - 8.5e-18 64.5 0.0 1.3e-11 44.6 0.0 2.1 2 0 0 2 2 2 2 Carbohydrate binding domain CBM49 CBM_2 PF00553.19 ELR19554.1 - 2.6e-07 30.9 2.7 2.8e-05 24.3 0.1 2.9 2 1 0 2 2 2 2 Cellulose binding domain Glyco_transf_34 PF05637.12 ELR19556.1 - 3.6e-15 56.3 0.9 3.9e-07 30.1 0.0 2.1 1 1 1 2 2 2 2 galactosyl transferase GMA12/MNN10 family DcpS_C PF11969.8 ELR19557.1 - 4.9e-16 59.2 0.2 1.1e-15 58.1 0.2 1.5 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding zf-C2HE PF16278.5 ELR19557.1 - 6.4e-15 55.4 0.4 2.1e-14 53.7 0.4 2.0 1 0 0 1 1 1 1 C2HE / C2H2 / C2HC zinc-binding finger HIT PF01230.23 ELR19557.1 - 3.7e-05 24.4 0.0 7.9e-05 23.3 0.0 1.5 1 0 0 1 1 1 1 HIT domain FAM176 PF14851.6 ELR19557.1 - 0.063 12.9 1.4 0.087 12.5 0.1 1.8 2 0 0 2 2 2 0 FAM176 family OAD_gamma PF04277.13 ELR19557.1 - 1.1 9.9 4.2 5.7 7.6 0.0 2.9 2 1 1 3 3 3 0 Oxaloacetate decarboxylase, gamma chain RR_TM4-6 PF06459.12 ELR19558.1 - 5 6.9 50.4 0.028 14.2 22.6 2.6 3 0 0 3 3 3 0 Ryanodine Receptor TM 4-6 SspH PF08141.12 ELR19559.1 - 0.082 13.0 0.0 0.15 12.2 0.0 1.3 1 0 0 1 1 1 0 Small acid-soluble spore protein H family Peptidase_C1 PF00112.23 ELR19560.1 - 4.2e-57 193.7 1.3 4.8e-57 193.5 0.5 1.5 2 0 0 2 2 2 1 Papain family cysteine protease Inhibitor_I29 PF08246.12 ELR19560.1 - 1.3e-08 35.1 0.1 2.3e-08 34.4 0.1 1.4 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Peptidase_C1_2 PF03051.15 ELR19560.1 - 0.032 13.0 0.7 1.4 7.6 0.0 2.1 2 0 0 2 2 2 0 Peptidase C1-like family DUF5637 PF18687.1 ELR19560.1 - 5.2 7.1 9.8 15 5.6 2.5 2.6 2 0 0 2 2 2 0 Family of unknown function (DUF5637) GARS_A PF01071.19 ELR19561.1 - 1.4e-82 276.2 0.0 2.7e-82 275.3 0.0 1.5 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain Formyl_trans_N PF00551.19 ELR19561.1 - 6.1e-46 156.4 0.0 1.2e-45 155.5 0.0 1.5 1 0 0 1 1 1 1 Formyl transferase GARS_N PF02844.15 ELR19561.1 - 1.7e-33 115.3 1.1 6.4e-33 113.4 0.5 2.4 2 0 0 2 2 2 1 Phosphoribosylglycinamide synthetase, N domain AIRS_C PF02769.22 ELR19561.1 - 1.9e-33 115.8 0.0 5.9e-33 114.2 0.0 1.9 1 0 0 1 1 1 1 AIR synthase related protein, C-terminal domain GARS_C PF02843.16 ELR19561.1 - 6.5e-28 96.8 0.7 3e-27 94.7 0.8 2.2 2 0 0 2 2 2 1 Phosphoribosylglycinamide synthetase, C domain AIRS PF00586.24 ELR19561.1 - 1.7e-14 54.2 2.8 3.6e-14 53.2 0.4 2.8 3 0 0 3 3 2 1 AIR synthase related protein, N-terminal domain ATP-grasp PF02222.22 ELR19561.1 - 0.00071 19.2 0.0 0.0023 17.5 0.0 1.8 1 0 0 1 1 1 1 ATP-grasp domain ATP-grasp_2 PF08442.10 ELR19561.1 - 0.0027 17.3 0.1 0.006 16.2 0.1 1.5 1 0 0 1 1 1 1 ATP-grasp domain ATP-grasp_3 PF02655.14 ELR19561.1 - 0.0083 16.2 0.0 0.022 14.8 0.0 1.7 1 0 0 1 1 1 1 ATP-grasp domain RimK PF08443.11 ELR19561.1 - 0.009 15.6 0.0 0.023 14.3 0.0 1.6 1 0 0 1 1 1 1 RimK-like ATP-grasp domain CPSase_L_D2 PF02786.17 ELR19561.1 - 0.016 14.7 0.0 0.032 13.7 0.0 1.5 1 0 0 1 1 1 0 Carbamoyl-phosphate synthase L chain, ATP binding domain Usp PF00582.26 ELR19561.1 - 0.056 13.9 4.1 0.075 13.5 0.1 3.1 2 1 0 2 2 2 0 Universal stress protein family PX PF00787.24 ELR19565.1 - 7e-22 77.5 2.4 1.2e-21 76.8 1.2 1.9 2 0 0 2 2 2 1 PX domain Ank_5 PF13857.6 ELR19565.1 - 8.3e-14 51.5 0.2 2.2e-07 31.0 0.1 3.4 1 1 2 3 3 3 2 Ankyrin repeats (many copies) SH3_1 PF00018.28 ELR19565.1 - 1.8e-12 46.7 0.1 3.4e-12 45.8 0.1 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 ELR19565.1 - 2.2e-11 43.4 0.2 3.7e-11 42.7 0.2 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 ELR19565.1 - 4.2e-11 42.4 0.0 8.8e-11 41.3 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain Ank_2 PF12796.7 ELR19565.1 - 6.9e-11 42.6 0.0 2.6e-10 40.7 0.0 1.9 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 ELR19565.1 - 2.8e-09 36.4 0.0 0.00019 21.6 0.0 2.6 2 0 0 2 2 2 2 Ankyrin repeat Ank_4 PF13637.6 ELR19565.1 - 1.3e-08 35.2 0.0 4.1e-08 33.6 0.0 1.8 1 1 1 2 2 2 1 Ankyrin repeats (many copies) Ank PF00023.30 ELR19565.1 - 2.1e-05 24.8 0.0 0.22 12.1 0.0 2.5 2 0 0 2 2 2 2 Ankyrin repeat DUF1098 PF06497.11 ELR19565.1 - 1.7 9.1 0.0 1.7 9.1 0.0 3.0 4 0 0 4 4 4 0 Protein of unknown function (DUF1098) KR PF08659.10 ELR19566.1 - 0.18 11.7 1.7 0.42 10.5 1.7 1.6 1 0 0 1 1 1 0 KR domain Abhydrolase_6 PF12697.7 ELR19567.1 - 4.1e-31 109.3 0.7 4.1e-31 109.3 0.7 1.9 2 0 0 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 ELR19567.1 - 1.4e-14 54.4 0.7 3.1e-14 53.2 0.2 2.0 2 1 0 2 2 2 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 ELR19567.1 - 5.1e-13 48.8 0.1 8.4e-13 48.1 0.1 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Thioesterase PF00975.20 ELR19567.1 - 1.2e-05 25.5 0.0 1.8e-05 25.0 0.0 1.3 1 0 0 1 1 1 1 Thioesterase domain Lipase_3 PF01764.25 ELR19567.1 - 0.00028 20.8 0.3 0.00064 19.6 0.3 1.5 1 0 0 1 1 1 1 Lipase (class 3) PGAP1 PF07819.13 ELR19567.1 - 0.00034 20.4 0.4 0.00065 19.5 0.4 1.4 1 0 0 1 1 1 1 PGAP1-like protein Abhydrolase_2 PF02230.16 ELR19567.1 - 0.0092 15.8 0.2 0.2 11.4 0.0 2.2 2 0 0 2 2 2 1 Phospholipase/Carboxylesterase Beta-lactamase2 PF13354.6 ELR19567.1 - 0.024 14.3 0.0 0.14 11.8 0.0 2.1 1 1 1 2 2 2 0 Beta-lactamase enzyme family Esterase PF00756.20 ELR19567.1 - 0.042 13.5 0.0 0.11 12.1 0.0 1.7 1 0 0 1 1 1 0 Putative esterase Cutinase PF01083.22 ELR19567.1 - 0.17 11.9 0.0 0.33 10.9 0.0 1.4 1 0 0 1 1 1 0 Cutinase Chlorophyllase2 PF12740.7 ELR19567.1 - 0.2 10.5 0.1 0.46 9.4 0.1 1.6 1 1 0 1 1 1 0 Chlorophyllase enzyme TMEM164 PF14808.6 ELR19569.1 - 1.2e-15 57.5 2.3 1.6e-15 57.2 2.3 1.2 1 0 0 1 1 1 1 TMEM164 family DUF2149 PF09919.9 ELR19569.1 - 0.16 12.2 0.0 0.43 10.9 0.0 1.7 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2149) Intg_mem_TP0381 PF09529.10 ELR19569.1 - 0.48 9.9 16.0 6.8 6.1 17.8 1.9 2 1 0 2 2 2 0 Integral membrane protein (intg_mem_TP0381) Pro_3_hydrox_C PF05373.11 ELR19570.1 - 0.0018 18.4 0.1 0.0024 17.9 0.1 1.3 1 1 0 1 1 1 1 L-proline 3-hydroxylase, C-terminal PSY3 PF16836.5 ELR19570.1 - 0.11 12.0 0.0 0.11 12.0 0.0 1.0 1 0 0 1 1 1 0 Shu complex component Psy3, DNA-binding description CBFB_NFYA PF02045.15 ELR19571.1 - 2.4e-22 79.3 5.2 4.4e-22 78.5 5.2 1.4 1 0 0 1 1 1 1 CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B tRNA-synt_2 PF00152.20 ELR19573.1 - 1.3e-71 241.3 0.0 1.7e-71 240.9 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 ELR19573.1 - 5.8e-10 39.0 0.0 1.1e-09 38.1 0.0 1.5 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.20 ELR19573.1 - 1.7e-06 27.7 0.1 0.0027 17.2 0.0 2.3 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) C2 PF00168.30 ELR19574.1 - 4e-54 181.2 0.1 2.1e-29 101.9 0.0 2.4 2 0 0 2 2 2 2 C2 domain RasGAP PF00616.19 ELR19574.1 - 3.9e-34 118.2 0.0 3.7e-20 72.5 0.0 2.8 2 1 1 3 3 3 2 GTPase-activator protein for Ras-like GTPase PLAC8 PF04749.17 ELR19576.1 - 4.2e-09 37.3 16.6 6.3e-09 36.7 16.6 1.2 1 0 0 1 1 1 1 PLAC8 family CcmB PF03379.13 ELR19576.1 - 0.17 11.4 0.0 0.21 11.1 0.0 1.1 1 0 0 1 1 1 0 CcmB protein LigB PF02900.18 ELR19577.1 - 2e-09 36.9 0.0 6.9e-05 22.0 0.0 2.2 2 0 0 2 2 2 2 Catalytic LigB subunit of aromatic ring-opening dioxygenase bPH_6 PF10756.9 ELR19577.1 - 0.092 12.8 0.1 11 6.1 0.0 2.4 2 0 0 2 2 2 0 Bacterial PH domain Ank_2 PF12796.7 ELR19578.1 - 4.3e-38 129.8 0.3 1.5e-09 38.3 0.0 5.7 2 2 3 5 5 5 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ELR19578.1 - 1.1e-35 121.5 4.9 5.3e-07 30.1 0.0 7.9 4 3 4 8 8 8 7 Ankyrin repeats (many copies) Ank PF00023.30 ELR19578.1 - 1.2e-35 120.4 4.3 6.2e-05 23.3 0.0 9.2 9 0 0 9 9 9 5 Ankyrin repeat Ank_5 PF13857.6 ELR19578.1 - 8e-27 93.0 6.4 4.8e-06 26.7 0.0 7.3 5 2 2 8 8 8 7 Ankyrin repeats (many copies) Ank_3 PF13606.6 ELR19578.1 - 1.3e-25 86.6 0.6 0.0067 16.9 0.0 9.4 10 0 0 10 10 10 6 Ankyrin repeat BTB PF00651.31 ELR19578.1 - 3.5e-20 72.3 0.4 5e-19 68.6 0.1 2.4 1 1 1 2 2 2 1 BTB/POZ domain CAF1 PF04857.20 ELR19578.1 - 0.22 10.7 5.1 21 4.1 8.7 2.0 2 0 0 2 2 2 0 CAF1 family ribonuclease Hid1 PF12722.7 ELR19578.1 - 1.7 6.7 8.5 2.4 6.2 8.5 1.2 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Mlh1_C PF16413.5 ELR19578.1 - 1.8 7.9 10.5 1 8.7 0.5 2.3 1 1 1 2 2 2 0 DNA mismatch repair protein Mlh1 C-terminus EOS1 PF12326.8 ELR19578.1 - 7 6.5 5.8 0.81 9.6 0.8 1.8 2 0 0 2 2 2 0 N-glycosylation protein DUF4832 PF16116.5 ELR19579.1 - 4.7e-11 43.0 0.0 5.7e-11 42.7 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4832) Ezh2_MCSS PF18600.1 ELR19581.1 - 0.18 11.5 0.0 0.31 10.7 0.0 1.4 1 0 0 1 1 1 0 MCSS domain DnaJ PF00226.31 ELR19583.1 - 1.5e-22 79.5 4.1 4.2e-22 78.0 4.1 1.8 1 0 0 1 1 1 1 DnaJ domain WD40 PF00400.32 ELR19584.1 - 0.00022 22.0 0.6 0.53 11.3 0.2 3.2 3 0 0 3 3 3 2 WD domain, G-beta repeat MCD PF05292.11 ELR19585.1 - 3.1e-51 174.4 0.0 3.9e-51 174.1 0.0 1.0 1 0 0 1 1 1 1 Malonyl-CoA decarboxylase C-terminal domain MCD PF05292.11 ELR19586.1 - 6.6e-12 45.5 0.0 9e-12 45.1 0.0 1.1 1 0 0 1 1 1 1 Malonyl-CoA decarboxylase C-terminal domain HisKA PF00512.25 ELR19587.1 - 6.6e-15 54.9 0.3 2.1e-14 53.3 0.3 1.9 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain HATPase_c PF02518.26 ELR19587.1 - 1.2e-13 51.5 0.0 5.7e-13 49.4 0.0 2.1 1 1 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 ELR19587.1 - 1.7e-08 34.6 0.0 3.3e-08 33.7 0.0 1.4 1 0 0 1 1 1 1 Response regulator receiver domain GAF_2 PF13185.6 ELR19587.1 - 0.0032 17.8 0.0 0.071 13.4 0.0 2.9 2 0 0 2 2 2 1 GAF domain Macoilin PF09726.9 ELR19587.1 - 2.9 6.3 11.0 4.6 5.7 11.0 1.2 1 0 0 1 1 1 0 Macoilin family HATPase_c PF02518.26 ELR19588.1 - 1.6e-22 80.1 0.0 4.6e-22 78.6 0.0 1.8 1 1 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 ELR19588.1 - 1.3e-17 64.0 0.0 2.5e-17 63.1 0.0 1.5 1 0 0 1 1 1 1 Response regulator receiver domain HisKA PF00512.25 ELR19588.1 - 0.038 14.0 0.9 0.089 12.8 0.1 2.1 2 0 0 2 2 2 0 His Kinase A (phospho-acceptor) domain Ist1 PF03398.14 ELR19589.1 - 5.3e-45 153.3 2.8 1e-44 152.4 2.8 1.5 1 0 0 1 1 1 1 Regulator of Vps4 activity in the MVB pathway I_LWEQ PF01608.17 ELR19589.1 - 2.5e-05 24.6 36.3 0.001 19.3 0.1 5.5 4 2 2 6 6 6 3 I/LWEQ domain JAB PF01398.21 ELR19590.1 - 4.2e-26 91.2 0.1 6.3e-26 90.7 0.1 1.3 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease BRCC36_C PF18110.1 ELR19590.1 - 3.3e-18 65.6 0.1 6.4e-18 64.7 0.1 1.5 1 0 0 1 1 1 1 BRCC36 C-terminal helical domain Prok-JAB PF14464.6 ELR19590.1 - 6.7e-08 32.3 0.1 1.2e-07 31.4 0.1 1.5 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain Tho2 PF11262.8 ELR19591.1 - 0.1 11.8 1.1 0.19 10.9 1.1 1.3 1 0 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 GLTSCR1 PF15249.6 ELR19591.1 - 0.67 10.4 7.1 0.92 10.0 4.9 2.2 2 0 0 2 2 2 0 Conserved region of unknown function on GLTSCR protein Shugoshin_N PF07558.11 ELR19591.1 - 2.5 8.0 7.4 0.67 9.9 2.2 2.4 2 0 0 2 2 2 0 Shugoshin N-terminal coiled-coil region YabA PF06156.13 ELR19591.1 - 2.6 8.7 11.8 3.6 8.3 6.2 3.1 2 1 1 3 3 3 0 Initiation control protein YabA DUF2892 PF11127.8 ELR19592.1 - 3.2e-06 27.1 1.0 5.3e-06 26.4 1.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2892) SDA1 PF05285.12 ELR19594.1 - 2.5e-05 23.9 12.2 3.1e-05 23.6 12.2 1.2 1 0 0 1 1 1 1 SDA1 BUD22 PF09073.10 ELR19594.1 - 4.8e-05 22.9 9.6 4.8e-05 22.9 9.6 1.4 2 0 0 2 2 1 1 BUD22 PTPRCAP PF15713.5 ELR19594.1 - 0.00021 21.6 11.5 0.0004 20.7 10.1 2.1 2 0 0 2 2 2 1 Protein tyrosine phosphatase receptor type C-associated DNA_pol_phi PF04931.13 ELR19594.1 - 0.00039 18.7 24.7 0.00051 18.3 24.7 1.2 1 0 0 1 1 1 1 DNA polymerase phi Nop14 PF04147.12 ELR19594.1 - 0.0013 17.1 19.6 0.0017 16.7 19.6 1.1 1 0 0 1 1 1 1 Nop14-like family ATP_bind_2 PF03668.15 ELR19594.1 - 0.0014 18.0 0.0 0.0096 15.3 0.0 2.1 2 0 0 2 2 2 1 P-loop ATPase protein family Cnd2 PF05786.14 ELR19594.1 - 0.0015 17.3 3.0 0.002 16.9 3.0 1.1 1 0 0 1 1 1 1 Condensin complex subunit 2 TFIIA PF03153.13 ELR19594.1 - 0.0017 18.5 9.5 0.0021 18.2 9.5 1.2 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit Mpp10 PF04006.12 ELR19594.1 - 0.003 16.1 13.7 0.0043 15.6 13.7 1.2 1 0 0 1 1 1 1 Mpp10 protein CDC45 PF02724.14 ELR19594.1 - 0.0036 15.7 10.9 0.0042 15.4 10.9 1.2 1 0 0 1 1 1 1 CDC45-like protein SpoIIIAH PF12685.7 ELR19594.1 - 0.0052 16.6 2.1 0.0055 16.5 2.1 1.2 1 0 0 1 1 1 1 SpoIIIAH-like protein CNDH2_C PF16858.5 ELR19594.1 - 0.029 14.3 3.7 0.037 13.9 3.7 1.2 1 0 0 1 1 1 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term CobT PF06213.12 ELR19594.1 - 0.05 13.0 19.7 0.089 12.2 19.7 1.4 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Presenilin PF01080.17 ELR19594.1 - 0.07 11.9 1.6 0.08 11.7 1.6 1.1 1 0 0 1 1 1 0 Presenilin SAPS PF04499.15 ELR19594.1 - 0.073 11.8 2.4 0.076 11.8 2.4 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein DUF913 PF06025.12 ELR19594.1 - 0.099 11.6 3.6 0.14 11.1 3.6 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Vfa1 PF08432.10 ELR19594.1 - 0.14 12.5 5.4 0.26 11.6 5.4 1.4 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Zip PF02535.22 ELR19594.1 - 0.23 10.6 0.7 0.27 10.4 0.7 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Paf1 PF03985.13 ELR19594.1 - 0.26 10.3 12.8 0.34 9.9 12.8 1.2 1 0 0 1 1 1 0 Paf1 CPSF100_C PF13299.6 ELR19594.1 - 0.31 11.2 3.9 0.57 10.4 3.9 1.4 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal RRN3 PF05327.11 ELR19594.1 - 0.31 9.5 18.2 0.42 9.1 18.2 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 SURF2 PF05477.11 ELR19594.1 - 0.32 10.7 6.8 0.52 10.0 6.8 1.4 1 0 0 1 1 1 0 Surfeit locus protein 2 (SURF2) V_ATPase_I PF01496.19 ELR19594.1 - 0.4 8.6 2.7 0.51 8.2 2.7 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family TRAP_alpha PF03896.16 ELR19594.1 - 0.64 9.2 10.0 1 8.5 10.0 1.3 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Pox_Ag35 PF03286.14 ELR19594.1 - 0.81 9.4 10.7 1.6 8.5 10.7 1.6 1 0 0 1 1 1 0 Pox virus Ag35 surface protein DUF4820 PF16091.5 ELR19594.1 - 0.85 8.9 4.3 1.3 8.3 4.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) NPR3 PF03666.13 ELR19594.1 - 1.3 7.7 5.5 1.9 7.2 5.5 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 RPN2_C PF18004.1 ELR19594.1 - 1.6 8.6 8.1 3.2 7.6 8.1 1.5 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain Afi1 PF07792.12 ELR19594.1 - 2.5 8.6 11.7 5 7.6 11.7 1.4 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking RNA_pol_Rpc4 PF05132.14 ELR19594.1 - 6.3 7.2 7.1 1 9.8 3.3 1.7 2 0 0 2 2 1 0 RNA polymerase III RPC4 PPP4R2 PF09184.11 ELR19594.1 - 6.6 6.2 23.7 9.1 5.8 23.7 1.2 1 0 0 1 1 1 0 PPP4R2 RNA_polI_A34 PF08208.11 ELR19594.1 - 7.6 6.6 12.0 0.96 9.5 7.6 1.6 2 0 0 2 2 2 0 DNA-directed RNA polymerase I subunit RPA34.5 Hydrolase_6 PF13344.6 ELR19595.1 - 1.5e-21 76.4 0.0 2.8e-21 75.5 0.0 1.5 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 ELR19595.1 - 3.5e-21 75.0 0.2 2.5e-20 72.3 0.0 2.3 2 0 0 2 2 2 1 HAD-hyrolase-like HAD_2 PF13419.6 ELR19595.1 - 1.7e-09 38.0 0.2 6.8e-06 26.3 0.0 2.2 2 0 0 2 2 2 2 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 ELR19595.1 - 2.7e-07 31.1 0.0 0.033 14.5 0.0 2.7 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Amidase02_C PF12123.8 ELR19595.1 - 0.028 14.1 0.1 12 5.7 0.0 2.6 2 0 0 2 2 2 0 N-acetylmuramoyl-l-alanine amidase Glucosamine_iso PF01182.20 ELR19596.1 - 9.6e-22 78.0 0.0 1.3e-21 77.5 0.0 1.2 1 0 0 1 1 1 1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase PP2C PF00481.21 ELR19597.1 - 4.1e-61 206.9 0.1 5.7e-61 206.4 0.1 1.2 1 0 0 1 1 1 1 Protein phosphatase 2C SpoIIE PF07228.12 ELR19597.1 - 2.2e-05 24.5 1.2 0.0028 17.6 0.0 2.2 2 0 0 2 2 2 2 Stage II sporulation protein E (SpoIIE) PP2C_2 PF13672.6 ELR19597.1 - 0.00093 18.9 2.5 0.0031 17.2 2.5 1.8 1 1 0 1 1 1 1 Protein phosphatase 2C Hypoth_Ymh PF09509.10 ELR19597.1 - 0.063 13.2 0.0 0.13 12.2 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (Hypoth_ymh) Pex14_N PF04695.13 ELR19597.1 - 0.87 10.2 12.3 12 6.5 0.9 3.1 3 0 0 3 3 3 0 Peroxisomal membrane anchor protein (Pex14p) conserved region SR-25 PF10500.9 ELR19597.1 - 1.2 8.7 9.7 0.12 12.0 2.7 2.1 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein Med3 PF11593.8 ELR19597.1 - 4.4 6.4 7.4 7.3 5.7 7.4 1.3 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal Polbeta PF18765.1 ELR19598.1 - 2.8e-05 24.1 0.0 7.7e-05 22.7 0.0 1.8 2 0 0 2 2 2 1 Polymerase beta, Nucleotidyltransferase NTP_transf_2 PF01909.23 ELR19598.1 - 6.8e-05 23.1 0.1 0.00018 21.7 0.0 1.7 2 0 0 2 2 2 1 Nucleotidyltransferase domain RlaP PF10127.9 ELR19598.1 - 0.0037 16.9 0.1 0.016 14.8 0.1 1.9 1 1 0 1 1 1 1 RNA repair pathway DNA polymerase beta family baeRF_family5 PF18846.1 ELR19598.1 - 0.39 10.9 5.0 1.1 9.5 0.1 2.3 1 1 1 2 2 2 0 Bacterial archaeo-eukaryotic release factor family 5 DUF4820 PF16091.5 ELR19599.1 - 0.0077 15.6 0.0 0.017 14.5 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4820) zf-BED PF02892.15 ELR19599.1 - 0.15 12.1 0.9 0.38 10.8 0.9 1.7 1 0 0 1 1 1 0 BED zinc finger Cyclin_N PF00134.23 ELR19600.1 - 6e-24 84.2 0.0 1.4e-10 41.0 0.0 2.3 2 0 0 2 2 2 2 Cyclin, N-terminal domain Cyclin PF08613.11 ELR19600.1 - 4.2e-16 59.7 1.3 9e-07 29.4 0.1 2.3 2 0 0 2 2 2 2 Cyclin Tropomyosin PF00261.20 ELR19600.1 - 0.083 12.2 2.9 5.9 6.2 0.2 2.1 2 0 0 2 2 2 0 Tropomyosin DUF4239 PF14023.6 ELR19600.1 - 0.14 11.8 0.0 35 4.0 0.0 2.9 4 0 0 4 4 4 0 Protein of unknown function (DUF4239) RNA_pol_Rpo13 PF12136.8 ELR19600.1 - 0.16 11.9 0.4 28 4.7 0.1 2.6 2 0 0 2 2 2 0 RNA polymerase Rpo13 subunit HTH domain DUF3754 PF12576.8 ELR19602.1 - 8.4e-10 38.7 0.0 1.4e-09 38.0 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3754) CDC45 PF02724.14 ELR19603.1 - 0.0041 15.5 4.0 0.005 15.2 4.0 1.1 1 0 0 1 1 1 1 CDC45-like protein Nop14 PF04147.12 ELR19603.1 - 0.022 13.0 7.0 0.022 13.0 7.0 1.1 1 0 0 1 1 1 0 Nop14-like family SDA1 PF05285.12 ELR19603.1 - 0.035 13.5 7.7 0.04 13.4 7.7 1.2 1 0 0 1 1 1 0 SDA1 BUD22 PF09073.10 ELR19603.1 - 0.079 12.3 10.9 0.089 12.1 10.9 1.1 1 0 0 1 1 1 0 BUD22 Orthopox_A36R PF05950.11 ELR19603.1 - 0.55 10.4 3.0 0.87 9.7 3.0 1.3 1 0 0 1 1 1 0 Orthopoxvirus A36R protein RRN3 PF05327.11 ELR19603.1 - 0.56 8.7 3.8 0.67 8.4 3.8 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 COPI_C PF06957.11 ELR19603.1 - 3.3 6.3 5.4 4.4 6.0 5.4 1.1 1 0 0 1 1 1 0 Coatomer (COPI) alpha subunit C-terminus eIF-3c_N PF05470.12 ELR19603.1 - 5.2 5.3 7.7 7.2 4.8 7.7 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 8 N-terminus DNA_pol_phi PF04931.13 ELR19603.1 - 9.6 4.2 17.0 13 3.8 17.0 1.1 1 0 0 1 1 1 0 DNA polymerase phi TPR_12 PF13424.6 ELR19604.1 - 2.1e-23 82.4 8.9 8.3e-11 42.0 0.3 3.4 1 1 1 3 3 3 3 Tetratricopeptide repeat TPR_10 PF13374.6 ELR19604.1 - 1e-12 47.4 8.6 1.9e-06 27.5 0.1 4.7 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_2 PF07719.17 ELR19604.1 - 2.2e-05 24.2 3.4 0.36 11.1 0.1 3.9 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_1 PF00515.28 ELR19604.1 - 7.3e-05 22.4 1.2 0.57 10.1 0.1 3.0 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_MalT PF17874.1 ELR19604.1 - 0.00018 21.0 0.1 0.00065 19.2 0.2 1.6 1 1 0 1 1 1 1 MalT-like TPR region TPR_7 PF13176.6 ELR19604.1 - 0.001 19.0 0.6 2.3 8.4 0.1 4.1 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_8 PF13181.6 ELR19604.1 - 0.048 13.9 3.7 9 6.8 0.0 3.8 4 0 0 4 4 4 0 Tetratricopeptide repeat ANAPC3 PF12895.7 ELR19604.1 - 0.11 12.7 2.4 27 5.1 0.0 3.5 2 1 1 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 ANAPC5 PF12862.7 ELR19604.1 - 0.13 12.4 0.0 0.35 11.0 0.0 1.8 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 5 TPR_14 PF13428.6 ELR19604.1 - 0.15 12.9 1.1 36 5.5 0.1 4.0 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_19 PF14559.6 ELR19604.1 - 0.68 10.5 6.6 8.2 7.0 0.1 3.4 4 0 0 4 4 3 0 Tetratricopeptide repeat DUF3754 PF12576.8 ELR19605.1 - 1.6e-10 41.1 0.1 2.6e-10 40.4 0.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3754) DUF826 PF05696.11 ELR19605.1 - 0.068 13.3 0.0 0.18 11.9 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF826) CsbD PF05532.12 ELR19606.1 - 3.2e-14 52.5 8.8 3.2e-14 52.5 8.8 2.0 1 1 1 2 2 2 2 CsbD-like PsiF_repeat PF07769.14 ELR19606.1 - 0.037 13.9 0.7 0.12 12.3 0.7 1.8 1 0 0 1 1 1 0 psiF repeat Peptidase_C1 PF00112.23 ELR19607.1 - 4.1e-65 219.9 3.0 5.2e-65 219.6 3.0 1.1 1 0 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.12 ELR19607.1 - 2e-14 53.8 0.8 3.6e-14 52.9 0.8 1.5 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Peptidase_C1_2 PF03051.15 ELR19607.1 - 0.00086 18.2 0.5 0.015 14.1 0.4 2.0 2 0 0 2 2 2 1 Peptidase C1-like family EpsG PF14897.6 ELR19607.1 - 0.17 11.1 0.2 0.3 10.3 0.2 1.3 1 0 0 1 1 1 0 EpsG family Rad51 PF08423.11 ELR19608.1 - 3e-18 66.0 0.0 5.3e-18 65.2 0.0 1.3 1 1 0 1 1 1 1 Rad51 RecA PF00154.21 ELR19608.1 - 4.4e-08 32.9 0.1 1.6e-07 31.0 0.0 1.8 2 0 0 2 2 2 1 recA bacterial DNA recombination protein DnaB_C PF03796.15 ELR19608.1 - 1.1e-05 24.9 0.1 0.017 14.5 0.0 2.1 2 0 0 2 2 2 2 DnaB-like helicase C terminal domain AAA_25 PF13481.6 ELR19608.1 - 0.00026 20.6 1.8 0.00055 19.6 1.8 1.5 1 1 0 1 1 1 1 AAA domain ATPase PF06745.13 ELR19608.1 - 0.00046 19.6 0.0 0.00073 19.0 0.0 1.3 1 0 0 1 1 1 1 KaiC AAA_16 PF13191.6 ELR19608.1 - 0.0039 17.6 0.6 0.0084 16.5 0.6 1.5 1 1 0 1 1 1 1 AAA ATPase domain CobU PF02283.16 ELR19608.1 - 0.0085 15.7 0.1 0.11 12.0 0.0 2.3 2 0 0 2 2 2 1 Cobinamide kinase / cobinamide phosphate guanyltransferase PAXNEB PF05625.11 ELR19608.1 - 0.17 11.0 1.4 7.5 5.6 0.1 2.1 2 0 0 2 2 2 0 PAXNEB protein ABC_ATPase PF09818.9 ELR19608.1 - 0.21 10.3 0.0 0.31 9.8 0.0 1.1 1 0 0 1 1 1 0 Predicted ATPase of the ABC class VASt PF16016.5 ELR19609.1 - 4.5e-10 40.1 0.0 7.7e-10 39.4 0.0 1.3 1 0 0 1 1 1 1 VAD1 Analog of StAR-related lipid transfer domain YabA PF06156.13 ELR19609.1 - 0.035 14.7 0.1 0.077 13.6 0.1 1.5 1 0 0 1 1 1 0 Initiation control protein YabA YscO PF07321.12 ELR19609.1 - 0.037 14.0 0.4 0.037 14.0 0.4 2.0 3 0 0 3 3 3 0 Type III secretion protein YscO MIS13 PF08202.11 ELR19609.1 - 0.052 12.8 0.1 0.081 12.2 0.1 1.3 1 0 0 1 1 1 0 Mis12-Mtw1 protein family DNA_pol_phi PF04931.13 ELR19609.1 - 0.1 10.6 1.4 0.13 10.3 1.4 1.1 1 0 0 1 1 1 0 DNA polymerase phi MRP-L20 PF12824.7 ELR19609.1 - 0.34 11.1 3.5 2.5 8.2 0.5 2.4 1 1 0 2 2 2 0 Mitochondrial ribosomal protein subunit L20 Vps26 PF03643.15 ELR19610.1 - 1.8e-49 168.2 0.2 2.5e-49 167.8 0.2 1.1 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 26 Arrestin_N PF00339.29 ELR19610.1 - 8.6e-08 32.4 0.0 2.7e-07 30.7 0.0 1.9 1 1 0 1 1 1 1 Arrestin (or S-antigen), N-terminal domain Arrestin_C PF02752.22 ELR19610.1 - 0.097 13.1 0.4 0.66 10.4 0.0 2.3 1 1 1 2 2 2 0 Arrestin (or S-antigen), C-terminal domain DUF1741 PF08427.10 ELR19612.1 - 8.3e-61 205.6 2.1 1.5e-60 204.8 2.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1741) DUF3361 PF11841.8 ELR19612.1 - 0.064 13.2 0.1 0.16 11.9 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3361) DUF3494 PF11999.8 ELR19613.1 - 3.4e-40 137.9 5.2 1.1e-37 129.8 5.2 2.1 1 1 0 1 1 1 1 Protein of unknown function (DUF3494) Peptidase_C1 PF00112.23 ELR19614.1 - 3e-37 128.8 0.0 3.7e-37 128.5 0.0 1.0 1 0 0 1 1 1 1 Papain family cysteine protease Peptidase_C1_2 PF03051.15 ELR19614.1 - 0.11 11.3 0.1 0.15 10.8 0.1 1.1 1 0 0 1 1 1 0 Peptidase C1-like family HA PF03457.14 ELR19615.1 - 2.2e-16 59.9 0.1 2.2e-16 59.9 0.1 2.8 2 0 0 2 2 2 1 Helicase associated domain HALZ PF02183.18 ELR19615.1 - 0.044 14.0 0.3 0.044 14.0 0.3 3.8 2 1 1 3 3 3 0 Homeobox associated leucine zipper Kelch_1 PF01344.25 ELR19616.1 - 9.1e-31 105.2 0.0 1.5e-08 34.1 0.0 5.9 5 1 0 5 5 5 5 Kelch motif Kelch_4 PF13418.6 ELR19616.1 - 8.1e-29 99.4 6.9 1.3e-06 28.3 0.0 6.0 5 1 0 5 5 5 5 Galactose oxidase, central domain Kelch_3 PF13415.6 ELR19616.1 - 8.3e-29 99.3 9.0 3.4e-08 33.6 0.1 6.4 6 1 0 6 6 6 5 Galactose oxidase, central domain Kelch_6 PF13964.6 ELR19616.1 - 2.9e-25 87.6 0.1 5.9e-05 23.2 0.0 6.0 5 1 0 5 5 5 4 Kelch motif Kelch_2 PF07646.15 ELR19616.1 - 4.2e-18 64.5 0.1 0.00032 20.6 0.0 5.7 5 1 0 5 5 5 4 Kelch motif Kelch_5 PF13854.6 ELR19616.1 - 4.8e-17 61.6 3.2 0.0023 17.9 0.0 5.6 5 1 0 5 5 5 5 Kelch motif DUF1668 PF07893.13 ELR19616.1 - 0.028 13.8 1.5 4.7 6.5 0.0 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF1668) TPT PF03151.16 ELR19617.1 - 6.7e-12 45.4 17.6 8.7e-12 45.0 17.6 1.1 1 0 0 1 1 1 1 Triose-phosphate Transporter family Gram_pos_anchor PF00746.21 ELR19617.1 - 1.4 9.0 4.3 11 6.1 0.2 3.3 1 1 1 2 2 2 0 LPXTG cell wall anchor motif AMP-binding PF00501.28 ELR19618.1 - 4.4e-73 246.3 0.2 9.6e-73 245.2 0.2 1.5 1 0 0 1 1 1 1 AMP-binding enzyme DUF3377 PF11857.8 ELR19619.1 - 0.11 12.4 1.4 0.21 11.6 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3377) Adeno_E3_CR2 PF02439.15 ELR19619.1 - 0.37 10.6 10.9 0.88 9.4 0.1 2.7 3 0 0 3 3 3 0 Adenovirus E3 region protein CR2 EphA2_TM PF14575.6 ELR19619.1 - 0.57 11.1 3.4 6.9 7.6 0.0 3.1 3 0 0 3 3 3 0 Ephrin type-A receptor 2 transmembrane domain P5-ATPase PF12409.8 ELR19619.1 - 0.83 9.8 0.1 0.83 9.8 0.1 2.9 4 0 0 4 4 4 0 P5-type ATPase cation transporter DUF4131 PF13567.6 ELR19619.1 - 1.1 8.9 9.5 0.37 10.4 3.5 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF4131) G3P_acyltransf PF02660.15 ELR19619.1 - 2.7 8.1 13.4 3.5 7.7 8.1 2.3 2 0 0 2 2 2 0 Glycerol-3-phosphate acyltransferase DUF4231 PF14015.6 ELR19619.1 - 3.9 8.0 6.9 1.7 9.2 3.3 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF4231) Mito_carr PF00153.27 ELR19620.1 - 6.8e-60 199.0 2.6 5.5e-21 74.3 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein RasGEF PF00617.19 ELR19622.1 - 1.1e-51 175.5 0.0 1.8e-51 174.9 0.0 1.3 1 0 0 1 1 1 1 RasGEF domain MRP-S27 PF10037.9 ELR19622.1 - 0.12 11.2 0.1 0.2 10.5 0.1 1.2 1 0 0 1 1 1 0 Mitochondrial 28S ribosomal protein S27 DUF4050 PF13259.6 ELR19623.1 - 9.8e-07 29.3 6.3 0.00038 20.8 0.4 2.1 1 1 1 2 2 2 2 Protein of unknown function (DUF4050) Peptidase_C65 PF10275.9 ELR19624.1 - 2.2e-06 27.3 0.0 0.009 15.5 0.1 2.5 1 1 1 2 2 2 2 Peptidase C65 Otubain OTU PF02338.19 ELR19624.1 - 3.1e-05 24.5 0.0 6.7e-05 23.4 0.0 1.6 1 0 0 1 1 1 1 OTU-like cysteine protease Kinetochor_Ybp2 PF08568.10 ELR19625.1 - 4.5e-22 78.3 0.0 1.6e-11 43.5 0.0 2.1 2 0 0 2 2 2 2 Uncharacterised protein family, YAP/Alf4/glomulin DRIM PF07539.12 ELR19625.1 - 0.18 10.1 0.0 0.36 9.1 0.0 1.6 1 1 0 1 1 1 0 Down-regulated in metastasis SAP PF02037.27 ELR19626.1 - 3.2e-08 33.1 0.6 6.8e-08 32.1 0.6 1.5 1 0 0 1 1 1 1 SAP domain DUF1087 PF06465.13 ELR19626.1 - 2.1 8.4 4.3 0.76 9.8 1.3 1.8 2 0 0 2 2 2 0 Domain of Unknown Function (DUF1087) Tau95 PF09734.9 ELR19627.1 - 2.5e-37 128.8 2.4 3.6e-37 128.3 0.6 2.0 2 0 0 2 2 2 1 RNA polymerase III transcription factor (TF)IIIC subunit HTH domain Tau95_N PF17682.1 ELR19627.1 - 1.4e-21 77.0 0.0 3.9e-21 75.6 0.0 1.8 1 1 0 1 1 1 1 Tau95 Triple barrel domain TFIIF_beta PF02270.15 ELR19627.1 - 0.0049 17.0 0.0 0.011 15.9 0.0 1.5 1 0 0 1 1 1 1 TFIIF, beta subunit HTH domain NOA36 PF06524.12 ELR19627.1 - 0.016 14.5 0.8 0.024 13.9 0.8 1.2 1 0 0 1 1 1 0 NOA36 protein DUF4611 PF15387.6 ELR19627.1 - 3.1 8.1 11.5 45 4.4 0.0 3.5 3 0 0 3 3 3 0 Domain of unknown function (DUF4611) Ran_BP1 PF00638.18 ELR19628.1 - 1.4e-48 164.2 2.9 2e-48 163.7 2.9 1.1 1 0 0 1 1 1 1 RanBP1 domain WH1 PF00568.23 ELR19628.1 - 0.0003 20.7 0.3 0.0015 18.5 0.3 1.9 1 1 0 1 1 1 1 WH1 domain CTD PF12815.7 ELR19628.1 - 0.016 15.8 9.0 0.036 14.6 8.5 1.9 2 0 0 2 2 2 0 Spt5 C-terminal nonapeptide repeat binding Spt4 Ubie_methyltran PF01209.18 ELR19629.1 - 8.9e-77 257.5 0.1 1.2e-76 257.2 0.1 1.1 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_25 PF13649.6 ELR19629.1 - 2.6e-15 56.9 0.0 1.3e-14 54.6 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ELR19629.1 - 4.7e-15 56.0 0.0 9.8e-15 55.0 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ELR19629.1 - 2.2e-09 37.3 0.0 4.9e-09 36.2 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ELR19629.1 - 3.4e-07 30.9 0.0 1.1e-06 29.2 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_8 PF05148.15 ELR19629.1 - 2.3e-05 24.3 0.2 0.00021 21.2 0.0 2.5 3 1 1 4 4 4 1 Hypothetical methyltransferase Methyltransf_23 PF13489.6 ELR19629.1 - 0.0036 17.2 0.0 0.0071 16.2 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 ELR19629.1 - 0.029 13.9 0.0 3 7.4 0.0 2.3 2 0 0 2 2 2 0 Methyltransferase small domain Methyltransf_5 PF01795.19 ELR19629.1 - 0.034 13.7 0.0 0.055 13.0 0.0 1.2 1 0 0 1 1 1 0 MraW methylase family Ribosomal_60s PF00428.19 ELR19629.1 - 0.053 14.1 0.3 0.11 13.1 0.3 1.5 1 0 0 1 1 1 0 60s Acidic ribosomal protein Transferase PF02458.15 ELR19630.1 - 3.2e-32 111.8 0.0 2.8e-18 65.8 0.0 2.8 2 1 0 2 2 2 2 Transferase family Mito_carr PF00153.27 ELR19631.1 - 2.7e-42 142.6 6.4 9.1e-20 70.4 0.1 3.1 2 1 1 3 3 3 3 Mitochondrial carrier protein PrcB_C PF14343.6 ELR19631.1 - 0.1 12.7 0.5 0.58 10.3 0.1 2.4 3 0 0 3 3 3 0 PrcB C-terminal Bacteriocin_IIc PF10439.9 ELR19631.1 - 2.1 8.5 7.1 9.3 6.5 0.2 2.4 2 0 0 2 2 2 0 Bacteriocin class II with double-glycine leader peptide WD40 PF00400.32 ELR19632.1 - 1.3e-23 82.9 0.1 6.2e-06 26.9 0.1 6.9 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ELR19632.1 - 5.3e-12 45.9 0.0 0.041 14.2 0.0 4.9 3 2 2 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ELR19632.1 - 0.097 11.3 0.0 0.75 8.4 0.0 1.9 2 0 0 2 2 2 0 Nucleoporin Nup120/160 SMC_N PF02463.19 ELR19633.1 - 6.7e-30 104.2 0.2 9.7e-30 103.6 0.2 1.2 1 0 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_15 PF13175.6 ELR19633.1 - 1.5e-13 51.3 0.1 1.5e-13 51.3 0.1 2.7 2 2 0 2 2 2 1 AAA ATPase domain AAA_23 PF13476.6 ELR19633.1 - 1.8e-10 41.7 63.1 8.5e-10 39.5 34.2 4.9 2 2 0 2 2 1 1 AAA domain AAA_21 PF13304.6 ELR19633.1 - 1.7e-06 28.1 6.6 0.00065 19.6 0.3 3.0 2 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_hinge PF06470.13 ELR19633.1 - 1.5e-05 25.3 0.0 4e-05 23.9 0.0 1.8 1 0 0 1 1 1 1 SMC proteins Flexible Hinge Domain DUF1664 PF07889.12 ELR19633.1 - 0.0014 18.7 39.3 0.52 10.4 3.2 6.7 3 2 3 7 7 7 3 Protein of unknown function (DUF1664) AAA_29 PF13555.6 ELR19633.1 - 0.0014 18.3 0.0 0.0033 17.1 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain DUF16 PF01519.16 ELR19633.1 - 0.0034 17.8 6.3 0.0034 17.8 6.3 6.4 3 3 2 5 5 4 1 Protein of unknown function DUF16 Fusion_gly PF00523.18 ELR19633.1 - 0.005 15.1 0.3 0.005 15.1 0.3 2.0 2 0 0 2 2 2 1 Fusion glycoprotein F0 HMMR_N PF15905.5 ELR19633.1 - 0.014 14.9 68.5 0.21 11.0 1.8 5.1 2 2 3 5 5 5 0 Hyaluronan mediated motility receptor N-terminal SbcCD_C PF13558.6 ELR19633.1 - 0.023 14.9 0.0 0.088 13.1 0.0 2.0 1 0 0 1 1 1 0 Putative exonuclease SbcCD, C subunit Spc7 PF08317.11 ELR19633.1 - 0.04 12.8 81.2 0.051 12.4 16.3 5.5 2 2 4 6 6 6 0 Spc7 kinetochore protein DUF5426 PF17473.2 ELR19633.1 - 0.11 12.7 0.6 10 6.4 0.0 2.8 2 0 0 2 2 2 0 Family of unknown function (DUF5426) ABC_tran PF00005.27 ELR19633.1 - 0.26 11.8 0.1 0.26 11.8 0.1 5.0 3 2 1 4 4 3 0 ABC transporter FlaC_arch PF05377.11 ELR19633.1 - 6 7.3 22.8 9.3 6.7 0.5 6.7 5 1 1 6 6 6 0 Flagella accessory protein C (FlaC) Tim17 PF02466.19 ELR19634.1 - 4.8e-08 33.4 0.1 1.1e-07 32.2 0.1 1.6 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family NIF PF03031.18 ELR19635.1 - 1e-54 184.5 0.9 1.3e-54 184.2 0.9 1.1 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase HAD PF12710.7 ELR19635.1 - 0.04 14.3 0.2 0.27 11.6 0.0 2.0 1 1 1 2 2 2 0 haloacid dehalogenase-like hydrolase PCI PF01399.27 ELR19636.1 - 6.1e-16 58.8 0.9 6e-15 55.7 0.2 2.4 2 0 0 2 2 2 1 PCI domain TPR_12 PF13424.6 ELR19636.1 - 0.0013 18.9 0.1 0.0043 17.3 0.1 1.9 1 0 0 1 1 1 1 Tetratricopeptide repeat CSN4_RPN5_eIF3a PF18420.1 ELR19636.1 - 0.0092 16.1 0.0 0.028 14.6 0.0 1.8 1 0 0 1 1 1 1 CSN4/RPN5/eIF3a helix turn helix domain TPR_14 PF13428.6 ELR19636.1 - 0.096 13.6 0.1 44 5.3 0.0 3.1 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_19 PF14559.6 ELR19636.1 - 0.098 13.2 4.8 3 8.4 0.1 3.3 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_7 PF13176.6 ELR19636.1 - 0.14 12.2 0.4 0.95 9.6 0.0 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat WD40 PF00400.32 ELR19637.1 - 2.5e-33 113.5 3.1 2.5e-06 28.1 0.2 7.1 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ELR19637.1 - 9.5e-07 29.0 0.0 1.3 9.4 0.0 4.5 3 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain PQQ PF01011.21 ELR19637.1 - 0.0012 18.7 0.2 0.0051 16.7 0.2 2.2 1 0 0 1 1 1 1 PQQ enzyme repeat PQQ_2 PF13360.6 ELR19637.1 - 0.02 14.5 6.4 0.04 13.5 0.9 2.9 2 1 2 4 4 4 0 PQQ-like domain WD40_like PF17005.5 ELR19637.1 - 0.25 10.6 0.0 8.6 5.6 0.0 2.1 1 1 0 2 2 2 0 WD40-like domain PA26 PF04636.13 ELR19638.1 - 4.1e-135 451.1 0.1 2.1e-134 448.8 0.1 1.8 1 1 0 1 1 1 1 PA26 p53-induced protein (sestrin) ABC_tran PF00005.27 ELR19639.1 - 2e-29 102.8 0.1 4e-29 101.9 0.1 1.5 1 0 0 1 1 1 1 ABC transporter RsgA_GTPase PF03193.16 ELR19639.1 - 0.0061 16.5 0.0 0.011 15.7 0.0 1.4 1 0 0 1 1 1 1 RsgA GTPase SbcCD_C PF13558.6 ELR19639.1 - 0.15 12.3 0.2 4.9 7.5 0.2 2.8 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit AAA_16 PF13191.6 ELR19639.1 - 0.15 12.4 0.4 0.33 11.3 0.4 1.8 1 1 0 1 1 1 0 AAA ATPase domain AAA_21 PF13304.6 ELR19639.1 - 1.7 8.4 4.2 17 5.1 0.1 2.3 1 1 1 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system 14-3-3 PF00244.20 ELR19640.1 - 5.7e-131 434.8 11.0 7.7e-105 349.3 2.2 2.0 1 1 1 2 2 2 2 14-3-3 protein DUF1320 PF07030.12 ELR19640.1 - 0.00021 21.4 0.8 0.73 10.0 0.1 3.3 3 0 0 3 3 3 2 Protein of unknown function (DUF1320) FRG PF08867.11 ELR19640.1 - 0.00023 22.0 1.0 1.4 9.9 0.0 3.0 3 0 0 3 3 3 2 FRG domain Orbi_VP5 PF00901.17 ELR19640.1 - 0.0024 16.3 4.2 0.0058 15.1 3.7 1.8 2 0 0 2 2 2 1 Orbivirus outer capsid protein VP5 Protoglobin PF11563.8 ELR19640.1 - 0.0039 17.1 0.3 4.4 7.2 0.0 2.9 2 1 1 3 3 3 2 Protoglobin DUF3014 PF11219.8 ELR19640.1 - 0.0042 17.4 3.0 0.37 11.1 0.1 2.3 1 1 1 2 2 2 2 Protein of unknown function (DUF3014) SF3A2 PF16835.5 ELR19640.1 - 0.0049 17.2 0.8 4 7.9 0.1 2.5 2 0 0 2 2 2 2 Pre-mRNA-splicing factor SF3a complex subunit 2 (Prp11) ATP-synt_D PF01813.17 ELR19640.1 - 0.092 12.6 6.5 0.038 13.8 3.0 2.1 2 1 0 2 2 2 0 ATP synthase subunit D CodY PF06018.14 ELR19640.1 - 0.11 12.0 2.7 4 6.9 0.5 2.2 1 1 1 2 2 2 0 CodY GAF-like domain Glu-tRNAGln PF02686.15 ELR19640.1 - 0.13 12.6 2.5 6.9 7.0 0.2 2.8 2 0 0 2 2 2 0 Glu-tRNAGln amidotransferase C subunit Bac_luciferase PF00296.20 ELR19640.1 - 0.14 11.6 1.0 1.2 8.5 0.1 2.4 2 0 0 2 2 2 0 Luciferase-like monooxygenase Sec34 PF04136.15 ELR19641.1 - 1.3e-34 119.2 0.0 2.7e-34 118.2 0.0 1.5 1 0 0 1 1 1 1 Sec34-like family VKOR PF07884.14 ELR19642.1 - 1e-20 74.2 15.0 1e-20 74.2 15.0 1.9 2 0 0 2 2 2 1 Vitamin K epoxide reductase family DUF716 PF04819.12 ELR19642.1 - 0.0022 17.7 0.6 0.0022 17.7 0.6 1.9 2 0 0 2 2 2 1 Family of unknown function (DUF716) Adeno_E3B PF03376.14 ELR19642.1 - 0.035 14.3 0.6 0.12 12.6 0.6 1.9 1 0 0 1 1 1 0 Adenovirus E3B protein CBM_5_12_2 PF14600.6 ELR19642.1 - 0.057 13.4 0.2 0.29 11.1 0.1 2.0 2 0 0 2 2 2 0 Cellulose-binding domain DUF4064 PF13273.6 ELR19642.1 - 0.23 11.8 3.9 2.5 8.4 0.0 2.7 1 1 2 3 3 3 0 Protein of unknown function (DUF4064) Phage_holin_2_4 PF16082.5 ELR19642.1 - 6.2 6.6 9.7 5.7 6.7 0.3 3.3 3 0 0 3 3 3 0 Bacteriophage holin family, superfamily II-like Maelstrom PF13017.6 ELR19643.1 - 1.7e-17 63.8 0.0 3.9e-17 62.6 0.0 1.6 2 0 0 2 2 2 1 piRNA pathway germ-plasm component RRM_1 PF00076.22 ELR19643.1 - 8.5e-11 41.5 0.0 1.5e-10 40.7 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) XS PF03468.14 ELR19643.1 - 0.0028 18.0 0.0 0.0068 16.7 0.0 1.6 1 0 0 1 1 1 1 XS domain Sporozoite_P67 PF05642.11 ELR19643.1 - 1 7.4 7.4 1.3 7.0 7.4 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Prefoldin PF02996.17 ELR19644.1 - 9.2e-30 103.0 1.8 9.2e-30 103.0 1.8 1.6 1 1 0 1 1 1 1 Prefoldin subunit Prefoldin_2 PF01920.20 ELR19644.1 - 4.2e-05 23.4 4.1 0.02 14.8 0.0 2.4 1 1 0 2 2 2 2 Prefoldin subunit Syntaxin-6_N PF09177.11 ELR19644.1 - 0.0019 18.7 3.7 2 9.0 3.7 2.4 1 1 0 1 1 1 1 Syntaxin 6, N-terminal Laminin_II PF06009.12 ELR19644.1 - 0.004 17.2 3.8 0.24 11.4 1.0 2.1 2 0 0 2 2 2 2 Laminin Domain II Prefoldin_3 PF13758.6 ELR19644.1 - 0.014 15.4 0.4 0.052 13.6 0.3 2.0 1 1 1 2 2 2 0 Prefoldin subunit Meis_PKNOX_N PF16493.5 ELR19644.1 - 0.014 15.7 0.7 1.3 9.5 0.1 2.3 2 0 0 2 2 2 0 N-terminal of Homeobox Meis and PKNOX1 NPV_P10 PF05531.12 ELR19644.1 - 0.016 15.7 1.3 1.1 9.8 0.1 2.4 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein DUF1664 PF07889.12 ELR19644.1 - 0.019 15.0 1.3 0.6 10.1 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) DHR10 PF18595.1 ELR19644.1 - 0.031 14.3 5.8 0.15 12.2 2.1 2.1 2 0 0 2 2 2 0 Designed helical repeat protein 10 domain End3 PF12761.7 ELR19644.1 - 0.061 13.5 2.8 0.3 11.2 2.9 1.8 1 1 0 1 1 1 0 Actin cytoskeleton-regulatory complex protein END3 Bcr-Abl_Oligo PF09036.10 ELR19644.1 - 0.11 12.5 1.2 1.8 8.6 0.0 2.6 2 1 1 3 3 3 0 Bcr-Abl oncoprotein oligomerisation domain TRAF_BIRC3_bd PF16673.5 ELR19644.1 - 0.4 10.5 3.0 0.31 10.9 0.3 2.0 2 0 0 2 2 2 0 TNF receptor-associated factor BIRC3 binding domain bZIP_1 PF00170.21 ELR19645.1 - 7 6.8 31.9 1.5 9.0 1.0 6.3 2 1 3 6 6 6 0 bZIP transcription factor RhoGAP PF00620.27 ELR19646.1 - 5.8e-27 94.4 0.2 2.2e-26 92.5 0.2 1.9 1 1 0 1 1 1 1 RhoGAP domain MIT PF04212.18 ELR19646.1 - 1.9e-07 31.0 5.7 3.9e-07 30.0 5.7 1.6 1 0 0 1 1 1 1 MIT (microtubule interacting and transport) domain PPR_2 PF13041.6 ELR19647.1 - 1.2e-11 44.6 0.0 0.017 15.3 0.0 4.0 3 2 1 4 4 4 3 PPR repeat family PPR_1 PF12854.7 ELR19647.1 - 2.2e-11 43.3 0.0 5.8e-05 22.7 0.0 3.6 4 0 0 4 4 4 2 PPR repeat PPR_3 PF13812.6 ELR19647.1 - 5.3e-11 42.4 0.0 0.023 14.8 0.0 3.4 3 1 0 3 3 3 3 Pentatricopeptide repeat domain PPR PF01535.20 ELR19647.1 - 4.1e-09 36.1 0.0 0.0013 18.8 0.0 3.4 3 0 0 3 3 3 2 PPR repeat PPR_long PF17177.4 ELR19647.1 - 5.2e-06 26.0 0.0 0.0033 16.8 0.0 2.1 1 1 1 2 2 2 2 Pentacotripeptide-repeat region of PRORP TPR_14 PF13428.6 ELR19647.1 - 3.4e-05 24.3 8.5 0.0042 17.8 0.6 4.3 3 2 2 5 5 5 1 Tetratricopeptide repeat TPR_19 PF14559.6 ELR19647.1 - 0.0023 18.4 1.5 0.0039 17.7 0.2 2.1 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_16 PF13432.6 ELR19647.1 - 0.01 16.5 1.7 0.01 16.5 1.7 2.4 2 1 1 3 3 3 0 Tetratricopeptide repeat Wzy_C_2 PF11846.8 ELR19647.1 - 0.021 14.7 0.2 0.7 9.8 0.2 2.2 1 1 1 2 2 2 0 Virulence factor membrane-bound polymerase, C-terminal CBP_BcsQ PF06564.12 ELR19647.1 - 0.064 12.7 0.0 0.1 12.1 0.0 1.3 1 0 0 1 1 1 0 Cellulose biosynthesis protein BcsQ TPR_4 PF07721.14 ELR19647.1 - 0.29 11.9 0.0 0.29 11.9 0.0 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat SnoaL_2 PF12680.7 ELR19648.1 - 5.5e-07 30.2 6.5 2.8e-05 24.7 0.4 2.3 2 0 0 2 2 2 2 SnoaL-like domain Cupin_8 PF13621.6 ELR19649.1 - 3e-24 86.1 0.1 6.1e-12 45.8 0.0 2.2 1 1 0 2 2 2 2 Cupin-like domain Cupin_4 PF08007.12 ELR19649.1 - 0.0022 17.5 0.0 0.0034 16.9 0.0 1.4 1 0 0 1 1 1 1 Cupin superfamily protein JmjC PF02373.22 ELR19649.1 - 0.033 14.6 0.1 0.07 13.6 0.1 1.5 1 0 0 1 1 1 0 JmjC domain, hydroxylase CH PF00307.31 ELR19650.1 - 1.6e-22 79.8 0.0 3.9e-22 78.5 0.0 1.6 1 0 0 1 1 1 1 Calponin homology (CH) domain PH PF00169.29 ELR19650.1 - 2e-20 73.3 0.0 7.8e-11 42.4 0.0 2.6 2 0 0 2 2 2 2 PH domain CAMSAP_CH PF11971.8 ELR19650.1 - 6.8e-06 25.8 0.0 1.1e-05 25.2 0.0 1.3 1 0 0 1 1 1 1 CAMSAP CH domain Phostensin_N PF13916.6 ELR19650.1 - 0.001 19.4 1.0 0.001 19.4 1.0 3.4 3 0 0 3 3 3 1 PP1-regulatory protein, Phostensin N-terminal PH_11 PF15413.6 ELR19650.1 - 0.0021 18.5 7.2 0.27 11.7 0.0 4.0 3 1 0 3 3 3 2 Pleckstrin homology domain PH_9 PF15410.6 ELR19650.1 - 0.019 15.3 0.1 0.93 9.9 0.0 2.8 1 1 1 2 2 2 0 Pleckstrin homology domain SAPS PF04499.15 ELR19650.1 - 1.9 7.2 18.8 3.5 6.3 18.8 1.3 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein EF-hand_1 PF00036.32 ELR19651.1 - 1.3e-10 40.1 1.9 0.00046 19.5 0.1 3.3 3 0 0 3 3 3 2 EF hand Acyltransferase PF01553.21 ELR19651.1 - 1.3e-10 41.0 0.1 4.1e-05 23.2 0.0 2.9 3 1 0 3 3 3 2 Acyltransferase EF-hand_5 PF13202.6 ELR19651.1 - 9.6e-09 34.4 0.6 0.0021 17.5 0.0 3.0 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 ELR19651.1 - 7.1e-07 29.0 0.4 0.025 14.4 0.0 2.7 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_7 PF13499.6 ELR19651.1 - 2.1e-06 28.1 9.0 0.00023 21.5 0.9 4.0 3 1 1 4 4 4 3 EF-hand domain pair EF-hand_6 PF13405.6 ELR19651.1 - 2.9e-06 26.8 0.5 0.027 14.4 0.0 3.2 3 0 0 3 3 3 2 EF-hand domain JmjN PF02375.17 ELR19651.1 - 0.0085 16.0 0.0 0.022 14.7 0.0 1.7 1 0 0 1 1 1 1 jmjN domain Ribosomal_60s PF00428.19 ELR19651.1 - 0.029 15.0 1.6 0.029 15.0 1.6 3.9 3 1 0 3 3 3 0 60s Acidic ribosomal protein EF-hand_4 PF12763.7 ELR19651.1 - 0.036 14.0 1.3 1.3 9.0 0.0 2.7 2 1 1 3 3 3 0 Cytoskeletal-regulatory complex EF hand Pox_Ag35 PF03286.14 ELR19651.1 - 0.037 13.8 0.4 0.037 13.8 0.4 3.6 2 2 1 3 3 3 0 Pox virus Ag35 surface protein PUF PF00806.19 ELR19652.1 - 2.2e-12 45.9 0.0 2.3 8.1 0.0 7.5 7 1 1 8 8 8 4 Pumilio-family RNA binding repeat DUF4908 PF16252.5 ELR19652.1 - 0.1 12.2 0.7 0.16 11.5 0.1 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4908) PPR_2 PF13041.6 ELR19653.1 - 1.7e-42 143.4 0.0 1.7e-07 31.4 0.0 11.0 6 2 5 11 11 11 11 PPR repeat family PPR_1 PF12854.7 ELR19653.1 - 9e-42 140.5 0.0 7.2e-07 28.8 0.0 11.0 12 0 0 12 12 12 6 PPR repeat PPR_3 PF13812.6 ELR19653.1 - 1.1e-34 118.3 0.0 7.6e-05 22.7 0.0 8.2 6 2 1 8 8 8 7 Pentatricopeptide repeat domain PPR PF01535.20 ELR19653.1 - 2.1e-33 112.2 0.0 0.0038 17.4 0.0 10.2 10 0 0 10 10 10 7 PPR repeat PPR_long PF17177.4 ELR19653.1 - 7.4e-17 61.4 0.0 0.00043 19.7 0.0 5.3 2 2 3 5 5 5 4 Pentacotripeptide-repeat region of PRORP TPR_14 PF13428.6 ELR19653.1 - 2e-06 28.1 12.1 0.034 14.9 0.4 7.9 8 1 1 9 9 9 1 Tetratricopeptide repeat TPR_19 PF14559.6 ELR19653.1 - 1.2e-05 25.7 2.3 0.018 15.5 0.1 4.9 3 1 2 5 5 5 1 Tetratricopeptide repeat Wzy_C_2 PF11846.8 ELR19653.1 - 0.00087 19.3 0.7 5.8 6.8 0.1 4.8 3 2 1 4 4 4 1 Virulence factor membrane-bound polymerase, C-terminal TPR_12 PF13424.6 ELR19653.1 - 0.0092 16.3 1.0 19 5.6 0.0 4.7 5 1 1 6 6 6 0 Tetratricopeptide repeat TPR_16 PF13432.6 ELR19653.1 - 0.022 15.4 9.0 0.83 10.4 1.0 5.2 5 2 0 5 5 5 0 Tetratricopeptide repeat Terminase_4 PF05119.12 ELR19653.1 - 0.032 14.7 0.0 0.2 12.1 0.0 2.4 1 1 1 2 2 2 0 Phage terminase, small subunit Glyco_transf_4 PF13439.6 ELR19653.1 - 0.039 14.0 0.5 0.15 12.1 0.2 2.1 2 0 0 2 2 2 0 Glycosyltransferase Family 4 ATP13 PF12921.7 ELR19653.1 - 0.04 13.8 0.0 6.4 6.7 0.0 3.6 3 1 0 4 4 4 0 Mitochondrial ATPase expression CysG_dimeriser PF10414.9 ELR19653.1 - 0.12 12.1 2.6 25 4.7 0.0 4.7 5 0 0 5 5 5 0 Sirohaem synthase dimerisation region TPR_4 PF07721.14 ELR19653.1 - 0.29 11.9 32.1 0.39 11.5 0.0 6.7 8 0 0 8 8 6 0 Tetratricopeptide repeat HECT PF00632.25 ELR19654.1 - 6.6e-74 249.2 0.0 8.4e-74 248.8 0.0 1.1 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) zf-RING_12 PF17976.1 ELR19654.1 - 0.00065 19.9 0.4 0.0014 18.8 0.4 1.5 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain F_actin_bund_C PF18060.1 ELR19655.1 - 9.7e-06 25.6 2.6 9.7e-06 25.6 2.6 4.4 2 1 2 4 4 2 1 F actin bundling C terminal RPOL_N PF14700.6 ELR19655.1 - 0.02 14.3 12.8 0.026 13.9 12.8 1.1 1 0 0 1 1 1 0 DNA-directed RNA polymerase N-terminal DUF812 PF05667.11 ELR19655.1 - 0.34 9.8 15.0 0.41 9.5 15.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF812) Golgin_A5 PF09787.9 ELR19655.1 - 0.5 9.8 12.9 0.67 9.4 12.9 1.2 1 0 0 1 1 1 0 Golgin subfamily A member 5 SLC12 PF03522.15 ELR19655.1 - 1.1 8.2 5.1 1.3 8.0 5.1 1.0 1 0 0 1 1 1 0 Solute carrier family 12 AAA_11 PF13086.6 ELR19655.1 - 2.8 7.7 10.7 4.2 7.1 10.7 1.3 1 0 0 1 1 1 0 AAA domain TPR_MLP1_2 PF07926.12 ELR19655.1 - 2.9 8.0 39.1 0.52 10.4 34.8 2.0 2 1 0 2 2 2 0 TPR/MLP1/MLP2-like protein ERM PF00769.19 ELR19655.1 - 3.5 7.4 37.4 4.9 6.9 37.4 1.2 1 0 0 1 1 1 0 Ezrin/radixin/moesin family TMPIT PF07851.13 ELR19655.1 - 3.5 6.8 5.4 4.2 6.5 5.4 1.3 1 0 0 1 1 1 0 TMPIT-like protein DDHD PF02862.17 ELR19655.1 - 3.6 7.7 5.5 4.4 7.4 5.5 1.2 1 0 0 1 1 1 0 DDHD domain AAA_13 PF13166.6 ELR19655.1 - 4.4 5.8 11.4 5.1 5.6 11.4 1.1 1 0 0 1 1 1 0 AAA domain Asp-B-Hydro_N PF05279.11 ELR19655.1 - 5.1 7.1 20.1 7.5 6.5 20.1 1.3 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region DUF4407 PF14362.6 ELR19655.1 - 5.4 6.3 23.7 7.9 5.7 23.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Alanine_zipper PF11839.8 ELR19655.1 - 5.5 7.4 77.0 8.5 6.8 20.0 3.3 1 1 2 3 3 1 0 Alanine-zipper, major outer membrane lipoprotein Presenilin PF01080.17 ELR19655.1 - 6.5 5.4 14.0 7 5.3 14.0 1.0 1 0 0 1 1 1 0 Presenilin BAF1_ABF1 PF04684.13 ELR19655.1 - 7.9 5.4 10.7 8.8 5.3 10.7 1.0 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor PPR_1 PF12854.7 ELR19656.1 - 1.2e-25 88.9 0.0 8.9e-06 25.3 0.0 6.7 6 1 0 6 6 6 4 PPR repeat PPR PF01535.20 ELR19656.1 - 2.9e-24 83.6 0.0 0.015 15.5 0.0 6.9 7 0 0 7 7 7 5 PPR repeat PPR_2 PF13041.6 ELR19656.1 - 2.7e-23 81.9 0.0 3.9e-08 33.3 0.0 6.1 2 1 4 6 6 6 5 PPR repeat family PPR_3 PF13812.6 ELR19656.1 - 6.3e-12 45.4 0.0 1.6e-05 24.9 0.0 3.6 3 0 0 3 3 3 3 Pentatricopeptide repeat domain PPR_long PF17177.4 ELR19656.1 - 1.9e-08 33.9 0.2 0.0061 16.0 0.0 2.8 1 1 1 2 2 2 2 Pentacotripeptide-repeat region of PRORP SPOB_a PF14689.6 ELR19656.1 - 0.042 13.5 0.1 22 4.8 0.0 4.2 5 0 0 5 5 5 0 Sensor_kinase_SpoOB-type, alpha-helical domain TPR_MLP1_2 PF07926.12 ELR19656.1 - 0.1 12.7 9.2 0.24 11.5 9.2 1.6 1 0 0 1 1 1 0 TPR/MLP1/MLP2-like protein DUF3584 PF12128.8 ELR19656.1 - 0.13 9.8 9.0 0.19 9.2 9.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) ECSIT PF06239.11 ELR19656.1 - 0.16 11.1 0.1 7.3 5.6 0.0 2.9 3 0 0 3 3 3 0 Evolutionarily conserved signalling intermediate in Toll pathway Wzy_C_2 PF11846.8 ELR19656.1 - 0.31 10.9 4.3 36 4.2 0.0 3.6 2 2 1 3 3 3 0 Virulence factor membrane-bound polymerase, C-terminal HSP70 PF00012.20 ELR19656.1 - 0.51 8.5 2.8 0.77 7.9 2.8 1.2 1 0 0 1 1 1 0 Hsp70 protein ARGLU PF15346.6 ELR19656.1 - 0.55 10.1 11.2 1.4 8.8 11.2 1.7 1 0 0 1 1 1 0 Arginine and glutamate-rich 1 DctP PF03480.13 ELR19656.1 - 2.3 7.5 4.7 29 3.9 0.0 2.2 2 0 0 2 2 2 0 Bacterial extracellular solute-binding protein, family 7 DUF1682 PF07946.14 ELR19656.1 - 3.8 6.6 9.5 6.3 5.9 9.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) RhoGAP PF00620.27 ELR19657.1 - 3.9e-32 111.2 0.0 6.6e-32 110.4 0.0 1.4 1 0 0 1 1 1 1 RhoGAP domain F_actin_bund_C PF18060.1 ELR19658.1 - 1.9e-19 69.6 14.2 1.9e-19 69.6 14.2 3.3 2 1 1 3 3 3 1 F actin bundling C terminal Methyltransf_24 PF13578.6 ELR19658.1 - 2.7 9.0 5.2 1.3 10.1 2.1 2.2 2 1 0 2 2 2 0 Methyltransferase domain RR_TM4-6 PF06459.12 ELR19658.1 - 5.6 6.7 10.8 8.2 6.2 10.8 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 F_actin_bund_C PF18060.1 ELR19659.1 - 2.1e-18 66.2 15.7 2.1e-18 66.2 15.7 4.3 1 1 2 3 3 3 1 F actin bundling C terminal Patatin PF01734.22 ELR19659.1 - 2.5 8.2 5.6 1.4 9.0 3.3 1.7 1 1 1 2 2 2 0 Patatin-like phospholipase ETF PF01012.21 ELR19660.1 - 2.8e-43 147.9 0.1 4.1e-43 147.4 0.1 1.2 1 0 0 1 1 1 1 Electron transfer flavoprotein domain NHL PF01436.21 ELR19661.1 - 1.3e-50 166.9 29.6 4.4e-10 39.1 0.2 6.7 6 0 0 6 6 6 6 NHL repeat DUF5128 PF17170.4 ELR19661.1 - 1.3e-15 57.4 0.0 7.5e-06 25.3 0.0 3.7 1 1 3 4 4 4 4 6-bladed beta-propeller zf-B_box PF00643.24 ELR19661.1 - 2.2e-12 46.9 16.7 1.5e-07 31.5 0.5 3.3 3 0 0 3 3 3 2 B-box zinc finger SGL PF08450.12 ELR19661.1 - 6.9e-08 32.4 12.5 8.2e-05 22.3 1.8 4.7 1 1 3 4 4 4 2 SMP-30/Gluconolactonase/LRE-like region zf-RING_5 PF14634.6 ELR19661.1 - 5.6e-06 26.2 1.4 5.6e-06 26.2 1.4 3.1 2 0 0 2 2 1 1 zinc-RING finger domain Arylesterase PF01731.20 ELR19661.1 - 5.5e-05 23.3 0.0 11 6.3 0.0 5.2 6 0 0 6 6 5 0 Arylesterase zf-C3HC4 PF00097.25 ELR19661.1 - 0.00078 19.3 0.6 0.00078 19.3 0.6 2.9 2 1 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) TolB_like PF15869.5 ELR19661.1 - 0.0008 18.7 0.0 0.07 12.4 0.0 3.0 1 1 3 4 4 4 1 TolB-like 6-blade propeller-like zf-RING_UBOX PF13445.6 ELR19661.1 - 0.00096 19.1 1.8 0.00096 19.1 1.8 2.8 4 0 0 4 4 3 1 RING-type zinc-finger Ldl_recept_b PF00058.17 ELR19661.1 - 0.0012 19.2 0.2 1.1e+02 3.4 0.0 5.7 6 1 0 6 6 5 0 Low-density lipoprotein receptor repeat class B DUF4082 PF13313.6 ELR19661.1 - 0.0016 18.5 1.5 3.8 7.5 0.0 3.7 1 1 3 4 4 4 1 Domain of unknown function (DUF4082) zf-RING_2 PF13639.6 ELR19661.1 - 0.0042 17.4 6.2 0.0042 17.4 6.2 4.0 2 2 1 3 3 2 1 Ring finger domain Lactonase PF10282.9 ELR19661.1 - 0.025 13.8 0.8 0.58 9.3 0.1 2.6 1 1 0 2 2 2 0 Lactonase, 7-bladed beta-propeller zf-RING_11 PF17123.5 ELR19661.1 - 0.026 14.3 0.4 0.026 14.3 0.4 2.7 3 0 0 3 3 2 0 RING-like zinc finger DUF3472 PF11958.8 ELR19661.1 - 0.22 12.0 1.1 1.1e+02 3.2 0.0 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF3472) Spectrin PF00435.21 ELR19661.1 - 0.74 10.3 6.5 0.046 14.2 1.3 1.7 2 0 0 2 2 1 0 Spectrin repeat zf-UBR PF02207.20 ELR19661.1 - 1.7 8.9 14.5 0.29 11.3 0.1 3.6 2 1 1 3 3 1 0 Putative zinc finger in N-recognin (UBR box) OmpH PF03938.14 ELR19661.1 - 3.5 8.0 11.4 7.3 6.9 11.4 1.5 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) ERM PF00769.19 ELR19661.1 - 6 6.6 17.8 9.7 5.9 17.8 1.2 1 0 0 1 1 1 0 Ezrin/radixin/moesin family Spc7 PF08317.11 ELR19661.1 - 8 5.2 8.7 2.4 7.0 5.1 1.6 1 1 1 2 2 2 0 Spc7 kinetochore protein GTP-bdg_M PF16360.5 ELR19661.1 - 9.2 6.9 14.4 3.7 8.2 4.1 2.6 1 1 1 2 2 2 0 GTP-binding GTPase Middle Region BRCT PF00533.26 ELR19662.1 - 2e-11 44.1 0.0 3.3e-11 43.4 0.0 1.4 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 ELR19662.1 - 1.5e-06 28.5 0.0 3.4e-06 27.4 0.0 1.6 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain PTCB-BRCT PF12738.7 ELR19662.1 - 9.4e-05 22.3 0.0 0.00017 21.4 0.0 1.5 1 0 0 1 1 1 1 twin BRCT domain LIG3_BRCT PF16759.5 ELR19662.1 - 0.015 15.6 0.0 0.027 14.8 0.0 1.4 1 0 0 1 1 1 0 DNA ligase 3 BRCT domain EF1_GNE PF00736.19 ELR19663.1 - 2.2e-29 101.5 1.1 2.2e-29 101.5 1.1 1.8 2 0 0 2 2 2 1 EF-1 guanine nucleotide exchange domain TMA7 PF09072.10 ELR19663.1 - 9.5 7.1 18.4 18 6.3 2.4 2.5 1 1 1 2 2 2 0 Translation machinery associated TMA7 DUF3800 PF12686.7 ELR19665.1 - 0.0012 19.5 0.0 2 9.1 0.0 4.8 2 1 0 2 2 2 1 Protein of unknown function (DUF3800) Baculo_PEP_C PF04513.12 ELR19665.1 - 0.027 14.5 0.3 0.027 14.5 0.3 6.2 5 1 1 7 7 7 0 Baculovirus polyhedron envelope protein, PEP, C terminus Phosphodiest PF01663.22 ELR19666.1 - 1.4e-39 136.7 0.0 1.9e-39 136.3 0.0 1.2 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.23 ELR19666.1 - 1.5e-07 31.1 0.0 0.00087 18.8 0.0 2.1 2 0 0 2 2 2 2 Sulfatase DUF229 PF02995.17 ELR19666.1 - 0.0016 17.1 0.0 0.002 16.8 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF229) Metalloenzyme PF01676.18 ELR19666.1 - 0.034 13.5 0.0 0.05 13.0 0.0 1.3 1 0 0 1 1 1 0 Metalloenzyme superfamily DEAD PF00270.29 ELR19667.1 - 5.6e-36 123.9 0.4 9.1e-36 123.2 0.4 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ELR19667.1 - 5.6e-25 87.9 0.2 1.5e-24 86.5 0.2 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 ELR19667.1 - 8.7e-05 22.6 0.0 0.00015 21.8 0.0 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_19 PF13245.6 ELR19667.1 - 0.022 15.1 0.2 0.044 14.1 0.2 1.6 1 1 0 1 1 1 0 AAA domain CMS1 PF14617.6 ELR19667.1 - 0.037 13.4 0.0 0.068 12.5 0.0 1.3 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit EF-hand_7 PF13499.6 ELR19668.1 - 3e-20 72.4 17.1 1.1e-09 38.6 0.4 3.5 1 1 3 4 4 4 4 EF-hand domain pair EF-hand_6 PF13405.6 ELR19668.1 - 4.4e-18 63.6 10.9 5.5e-05 22.8 0.0 5.5 7 0 0 7 7 7 4 EF-hand domain EF-hand_1 PF00036.32 ELR19668.1 - 9.2e-18 62.4 9.5 0.00046 19.6 0.0 4.9 5 0 0 5 5 5 4 EF hand EF-hand_8 PF13833.6 ELR19668.1 - 3.3e-15 55.7 4.2 0.00011 22.0 0.5 4.5 3 1 1 4 4 4 4 EF-hand domain pair Acyltransferase PF01553.21 ELR19668.1 - 3.1e-11 43.0 0.0 6.1e-11 42.1 0.0 1.4 1 0 0 1 1 1 1 Acyltransferase EF-hand_5 PF13202.6 ELR19668.1 - 1.1e-10 40.5 13.1 0.04 13.4 0.0 4.9 5 0 0 5 5 5 4 EF hand EF-hand_4 PF12763.7 ELR19668.1 - 4.5e-05 23.3 0.0 0.43 10.6 0.0 2.7 1 1 1 2 2 2 2 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.6 ELR19668.1 - 0.00017 21.9 0.1 0.0085 16.4 0.0 2.4 1 1 1 2 2 2 1 EF-hand domain EF-hand_11 PF08976.11 ELR19668.1 - 0.00064 20.6 0.0 0.0027 18.5 0.0 1.9 1 1 0 2 2 2 1 EF-hand domain SPARC_Ca_bdg PF10591.9 ELR19668.1 - 0.039 14.3 0.0 1.3 9.3 0.0 2.5 2 0 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region NCD1 PF04904.13 ELR19668.1 - 0.1 12.6 0.0 0.27 11.3 0.0 1.7 1 0 0 1 1 1 0 NAB conserved region 1 (NCD1) DUF4336 PF14234.6 ELR19669.1 - 0.0071 15.6 1.2 0.011 14.9 1.2 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4336) DUF812 PF05667.11 ELR19669.1 - 0.062 12.2 12.3 0.093 11.6 12.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF812) MOR2-PAG1_N PF14222.6 ELR19669.1 - 0.1 11.6 2.0 0.15 10.9 2.0 1.3 1 0 0 1 1 1 0 Cell morphogenesis N-terminal F_actin_bund_C PF18060.1 ELR19670.1 - 3.1e-18 65.7 13.6 3.1e-18 65.7 13.6 3.3 2 1 1 3 3 3 2 F actin bundling C terminal F_actin_bund_C PF18060.1 ELR19671.1 - 2e-17 63.1 18.2 2e-17 63.1 18.2 3.6 2 1 1 3 3 3 1 F actin bundling C terminal YopH_N PF09013.10 ELR19671.1 - 0.12 12.7 4.6 0.3 11.4 4.6 1.7 1 0 0 1 1 1 0 YopH, N-terminal Patatin PF01734.22 ELR19671.1 - 0.77 9.9 2.2 0.96 9.6 1.4 1.5 1 1 1 2 2 2 0 Patatin-like phospholipase DRMBL PF07522.14 ELR19672.1 - 8.2e-10 38.8 0.0 2e-09 37.6 0.0 1.6 1 0 0 1 1 1 1 DNA repair metallo-beta-lactamase Lactamase_B_2 PF12706.7 ELR19672.1 - 0.00028 20.5 0.0 0.00091 18.8 0.0 1.8 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B PF00753.27 ELR19672.1 - 0.025 14.6 2.6 0.4 10.7 0.5 2.9 4 0 0 4 4 4 0 Metallo-beta-lactamase superfamily Bindin PF02084.15 ELR19672.1 - 0.19 12.0 3.1 0.38 11.0 3.1 1.4 1 0 0 1 1 1 0 Bindin DUF3995 PF13160.6 ELR19673.1 - 0.15 12.5 0.0 0.15 12.5 0.0 2.9 3 1 0 3 3 3 0 Protein of unknown function (DUF3995) DUF716 PF04819.12 ELR19673.1 - 0.19 11.3 7.4 0.046 13.4 3.4 2.0 2 1 0 2 2 2 0 Family of unknown function (DUF716) Spectrin PF00435.21 ELR19674.1 - 0.057 13.9 0.4 0.12 12.9 0.4 1.5 1 0 0 1 1 1 0 Spectrin repeat DUF4755 PF15947.5 ELR19674.1 - 0.14 12.1 0.0 0.28 11.1 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4755) PH PF00169.29 ELR19677.1 - 9.9e-07 29.2 7.8 2.8e-06 27.8 0.1 2.9 3 0 0 3 3 3 2 PH domain RskA PF10099.9 ELR19677.1 - 1.5 9.1 10.8 0.63 10.3 0.6 2.3 2 0 0 2 2 2 0 Anti-sigma-K factor rskA PI3_PI4_kinase PF00454.27 ELR19679.1 - 1.7e-40 139.4 0.2 9.1e-39 133.8 0.2 2.4 1 1 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase PI3Ka PF00613.20 ELR19679.1 - 1.8e-39 135.1 0.3 2.8e-39 134.5 0.3 1.3 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) PI3K_C2 PF00792.24 ELR19679.1 - 5.2e-14 52.4 0.0 1.1e-13 51.3 0.0 1.5 1 0 0 1 1 1 1 Phosphoinositide 3-kinase C2 DUF4135 PF13575.6 ELR19679.1 - 0.0032 16.8 0.0 0.0063 15.9 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4135) PRAI PF00697.22 ELR19680.1 - 1.6e-14 54.1 0.0 2.1e-14 53.7 0.0 1.2 1 0 0 1 1 1 1 N-(5'phosphoribosyl)anthranilate (PRA) isomerase RFX_DNA_binding PF02257.15 ELR19681.1 - 7.9e-17 61.7 0.2 1.6e-16 60.7 0.2 1.4 1 0 0 1 1 1 1 RFX DNA-binding domain Pox_D5 PF03288.16 ELR19681.1 - 0.08 13.4 0.0 0.15 12.6 0.0 1.4 1 0 0 1 1 1 0 Poxvirus D5 protein-like RFX_DNA_binding PF02257.15 ELR19682.1 - 8e-08 32.8 0.0 9.3e-08 32.6 0.0 1.1 1 0 0 1 1 1 1 RFX DNA-binding domain Pox_D5 PF03288.16 ELR19682.1 - 0.073 13.6 0.0 0.087 13.3 0.0 1.1 1 0 0 1 1 1 0 Poxvirus D5 protein-like Zip PF02535.22 ELR19683.1 - 9.9 5.3 7.0 14 4.8 7.0 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter RhoGEF PF00621.20 ELR19685.1 - 5.7e-36 124.5 0.0 2.8e-35 122.2 0.0 2.2 2 1 0 2 2 2 1 RhoGEF domain FYVE PF01363.21 ELR19685.1 - 1.5e-17 63.5 1.3 2.7e-17 62.6 1.3 1.4 1 0 0 1 1 1 1 FYVE zinc finger SH3_1 PF00018.28 ELR19685.1 - 7.2e-13 47.9 0.1 1.5e-12 46.9 0.1 1.6 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 ELR19685.1 - 2e-12 46.7 0.1 3.9e-12 45.8 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain PH PF00169.29 ELR19685.1 - 6.2e-10 39.5 0.1 1.9e-09 37.9 0.1 1.9 1 0 0 1 1 1 1 PH domain SH3_2 PF07653.17 ELR19685.1 - 1.9e-07 30.7 0.0 4.2e-07 29.6 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain PH_13 PF16652.5 ELR19685.1 - 0.0011 18.9 0.3 0.0027 17.6 0.3 1.6 1 0 0 1 1 1 1 Pleckstrin homology domain CENP-B_dimeris PF09026.10 ELR19685.1 - 0.011 16.1 1.1 0.026 14.9 1.1 1.6 1 0 0 1 1 1 0 Centromere protein B dimerisation domain FYVE_2 PF02318.16 ELR19685.1 - 0.016 15.4 3.2 0.05 13.8 3.2 1.8 1 0 0 1 1 1 0 FYVE-type zinc finger SH3_3 PF08239.11 ELR19685.1 - 0.13 12.6 0.0 0.25 11.6 0.0 1.5 1 0 0 1 1 1 0 Bacterial SH3 domain zf-B_box PF00643.24 ELR19685.1 - 0.18 12.0 4.6 0.44 10.7 4.6 1.6 1 0 0 1 1 1 0 B-box zinc finger zf_C2HC_14 PF18574.1 ELR19685.1 - 0.24 11.2 4.6 0.44 10.4 4.6 1.4 1 0 0 1 1 1 0 C2HC Zing finger domain RFX_DNA_binding PF02257.15 ELR19686.1 - 1.2e-17 64.3 0.2 2.1e-17 63.5 0.2 1.4 1 0 0 1 1 1 1 RFX DNA-binding domain Pox_D5 PF03288.16 ELR19686.1 - 0.15 12.5 0.1 0.24 11.9 0.1 1.3 1 0 0 1 1 1 0 Poxvirus D5 protein-like PHO4 PF01384.20 ELR19687.1 - 2.2e-76 257.1 0.0 4.6e-64 216.6 0.0 2.8 2 1 0 2 2 2 2 Phosphate transporter family PPR_2 PF13041.6 ELR19688.1 - 2e-38 130.3 3.1 1.7e-08 34.5 0.0 8.7 5 3 4 9 9 9 8 PPR repeat family PPR PF01535.20 ELR19688.1 - 1.3e-28 97.1 6.6 2.6e-05 24.1 0.0 9.5 10 0 0 10 10 10 6 PPR repeat PPR_3 PF13812.6 ELR19688.1 - 9e-25 86.5 0.0 3.5e-05 23.8 0.0 5.5 5 0 0 5 5 5 5 Pentatricopeptide repeat domain PPR_1 PF12854.7 ELR19688.1 - 4.4e-18 64.7 0.1 6.7e-05 22.5 0.0 6.9 7 0 0 7 7 7 4 PPR repeat PPR_long PF17177.4 ELR19688.1 - 1.5e-17 63.7 7.2 4.5e-08 32.7 0.1 5.5 1 1 5 6 6 6 5 Pentacotripeptide-repeat region of PRORP TPR_16 PF13432.6 ELR19688.1 - 0.0051 17.4 2.1 0.023 15.4 1.0 2.7 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.6 ELR19688.1 - 0.032 15.0 7.7 0.9 10.5 0.1 4.9 5 0 0 5 5 5 0 Tetratricopeptide repeat DHFR_1 PF00186.19 ELR19689.1 - 7.2e-27 94.1 0.0 6.2e-24 84.5 0.0 2.2 1 1 0 1 1 1 1 Dihydrofolate reductase Thymidylat_synt PF00303.19 ELR19689.1 - 2.6e-26 92.3 0.2 3.7e-26 91.9 0.2 1.1 1 0 0 1 1 1 1 Thymidylate synthase DUF21 PF01595.20 ELR19690.1 - 5.9e-31 107.5 0.8 9e-31 106.9 0.8 1.3 1 0 0 1 1 1 1 Cyclin M transmembrane N-terminal domain CBS PF00571.28 ELR19690.1 - 2.8e-08 34.1 0.4 4.8e-05 23.7 0.0 2.7 2 0 0 2 2 2 2 CBS domain PHO4 PF01384.20 ELR19690.1 - 0.17 10.9 0.1 0.18 10.8 0.1 1.2 1 0 0 1 1 1 0 Phosphate transporter family CX9C PF16860.5 ELR19691.1 - 2.1e-05 24.4 1.9 0.017 15.2 0.0 3.3 3 0 0 3 3 3 2 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, CHCH PF06747.13 ELR19691.1 - 6.1e-05 23.1 3.6 0.0057 16.7 0.1 3.2 3 0 0 3 3 3 2 CHCH domain SPESP1 PF15754.5 ELR19693.1 - 0.037 13.2 1.3 0.053 12.7 1.3 1.1 1 0 0 1 1 1 0 Sperm equatorial segment protein 1 Ig_5 PF16681.5 ELR19693.1 - 0.27 11.7 4.9 2.2 8.7 2.0 2.4 2 0 0 2 2 2 0 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain ABC1 PF03109.16 ELR19694.1 - 3.4e-20 72.4 0.0 6.3e-20 71.5 0.0 1.4 1 0 0 1 1 1 1 ABC1 family RFX_DNA_binding PF02257.15 ELR19695.1 - 7e-06 26.6 0.0 2e-05 25.1 0.0 1.7 1 1 0 1 1 1 1 RFX DNA-binding domain SR-25 PF10500.9 ELR19695.1 - 2.9 7.5 5.2 15 5.1 1.3 2.2 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein HAUS-augmin3 PF14932.6 ELR19696.1 - 4.1e-16 59.3 3.1 4.1e-16 59.3 3.1 2.5 3 1 0 3 3 3 1 HAUS augmin-like complex subunit 3 FliD_N PF02465.18 ELR19696.1 - 0.0016 19.1 1.6 0.96 10.2 0.1 3.4 2 1 0 2 2 2 1 Flagellar hook-associated protein 2 N-terminus Surfac_D-trimer PF09006.11 ELR19696.1 - 0.0023 17.8 0.4 1.6 8.6 0.1 3.2 3 0 0 3 3 3 1 Lung surfactant protein D coiled-coil trimerisation Tho2 PF11262.8 ELR19696.1 - 0.0032 16.7 1.3 0.21 10.7 0.8 2.3 2 0 0 2 2 2 1 Transcription factor/nuclear export subunit protein 2 THOC7 PF05615.13 ELR19696.1 - 0.006 16.9 12.5 0.011 16.1 1.2 3.4 3 1 0 3 3 3 1 Tho complex subunit 7 Fib_alpha PF08702.10 ELR19696.1 - 0.17 12.0 1.4 7.8 6.7 0.7 3.2 3 0 0 3 3 3 0 Fibrinogen alpha/beta chain family Fez1 PF06818.15 ELR19696.1 - 0.42 11.0 12.3 0.053 14.0 3.3 3.0 3 0 0 3 3 3 0 Fez1 DUF2730 PF10805.8 ELR19696.1 - 0.42 10.7 2.6 28 4.9 0.5 3.5 3 0 0 3 3 3 0 Protein of unknown function (DUF2730) MIF4G_like_2 PF09090.11 ELR19696.1 - 0.48 9.8 4.3 0.21 11.0 1.3 1.9 2 0 0 2 2 2 0 MIF4G like TMPIT PF07851.13 ELR19696.1 - 0.6 9.3 2.2 0.59 9.3 0.3 1.9 2 0 0 2 2 2 0 TMPIT-like protein Cob_adeno_trans PF01923.18 ELR19696.1 - 0.84 9.8 8.6 3.4 7.8 0.7 3.4 4 0 0 4 4 4 0 Cobalamin adenosyltransferase JIP_LZII PF16471.5 ELR19696.1 - 0.99 9.6 5.2 0.6 10.3 1.2 2.9 3 0 0 3 3 2 0 JNK-interacting protein leucine zipper II CENP-F_leu_zip PF10473.9 ELR19696.1 - 1.3 9.0 15.8 0.23 11.5 9.8 2.7 3 0 0 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 TACC_C PF05010.14 ELR19696.1 - 7.1 6.4 13.2 0.047 13.5 2.6 2.6 4 0 0 4 4 4 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal GDC-P PF02347.16 ELR19697.1 - 1.4e-185 617.3 0.3 1.3e-171 571.2 0.4 2.7 3 0 0 3 3 3 2 Glycine cleavage system P-protein Aminotran_5 PF00266.19 ELR19697.1 - 6.4e-07 28.7 1.5 0.00015 20.8 0.2 2.3 2 0 0 2 2 2 2 Aminotransferase class-V Beta_elim_lyase PF01212.21 ELR19697.1 - 0.0002 20.7 0.3 0.0095 15.2 0.0 2.6 2 1 0 2 2 2 1 Beta-eliminating lyase DivIVA PF05103.13 ELR19698.1 - 0.12 12.5 16.1 0.15 12.1 1.7 3.3 3 0 0 3 3 3 0 DivIVA protein NLRC4_HD PF17889.1 ELR19698.1 - 1.1 9.7 3.0 0.6 10.5 0.1 2.0 2 0 0 2 2 2 0 NLRC4 helical domain YL1 PF05764.13 ELR19698.1 - 3.4 7.7 20.8 9.5 6.3 0.0 2.5 2 1 0 2 2 2 0 YL1 nuclear protein SRF-TF PF00319.18 ELR19699.1 - 2.3e-19 68.6 0.2 3.9e-19 67.9 0.2 1.4 1 0 0 1 1 1 1 SRF-type transcription factor (DNA-binding and dimerisation domain) RCC1 PF00415.18 ELR19700.1 - 2.5e-73 242.5 31.2 1.7e-15 57.3 1.3 7.8 8 0 0 8 8 8 7 Regulator of chromosome condensation (RCC1) repeat BTB PF00651.31 ELR19700.1 - 8.7e-35 119.3 0.0 4.2e-17 62.4 0.0 3.1 2 1 0 2 2 2 2 BTB/POZ domain RCC1_2 PF13540.6 ELR19700.1 - 9.5e-32 108.1 43.6 1.2e-06 28.2 2.2 7.4 7 0 0 7 7 7 7 Regulator of chromosome condensation (RCC1) repeat Glyco_hydro_39 PF01229.17 ELR19701.1 - 8.7e-121 403.9 0.5 2.1e-120 402.6 0.5 1.6 1 1 0 1 1 1 1 Glycosyl hydrolases family 39 TPR_14 PF13428.6 ELR19702.1 - 0.064 14.1 0.2 0.6 11.1 0.0 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_2 PF07719.17 ELR19702.1 - 0.08 13.1 0.0 0.49 10.6 0.0 2.1 2 0 0 2 2 2 0 Tetratricopeptide repeat WD40 PF00400.32 ELR19703.1 - 3.9e-48 160.4 22.2 2.2e-08 34.6 0.1 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ELR19703.1 - 1e-10 41.8 0.8 0.34 11.2 0.0 4.8 2 2 1 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain Cytochrom_D1 PF02239.16 ELR19703.1 - 0.0001 21.0 0.0 0.057 11.9 0.1 2.2 2 0 0 2 2 2 2 Cytochrome D1 heme domain Nup160 PF11715.8 ELR19703.1 - 0.00016 20.5 10.8 0.12 11.0 0.2 4.3 3 1 2 5 5 5 2 Nucleoporin Nup120/160 Nbas_N PF15492.6 ELR19703.1 - 0.015 14.6 0.0 0.43 9.9 0.0 2.5 2 0 0 2 2 2 0 Neuroblastoma-amplified sequence, N terminal WD40_like PF17005.5 ELR19703.1 - 0.033 13.5 0.0 0.44 9.8 0.0 2.4 2 1 0 2 2 2 0 WD40-like domain PD40 PF07676.12 ELR19703.1 - 0.073 13.0 0.1 36 4.5 0.1 4.4 6 0 0 6 6 6 0 WD40-like Beta Propeller Repeat MeaB PF03308.16 ELR19704.1 - 1.6e-96 322.4 1.2 7.4e-96 320.2 1.2 1.8 1 1 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB cobW PF02492.19 ELR19704.1 - 1.1e-06 28.3 0.1 7.1e-06 25.7 0.1 2.0 1 1 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain ATP_bind_1 PF03029.17 ELR19704.1 - 0.0004 20.2 0.0 0.0035 17.2 0.0 2.3 2 1 0 2 2 2 1 Conserved hypothetical ATP binding protein AAA_24 PF13479.6 ELR19704.1 - 0.002 17.9 0.0 0.0038 17.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 ELR19704.1 - 0.0024 18.4 0.4 0.0047 17.5 0.0 1.9 2 0 0 2 2 2 1 AAA domain MMR_HSR1 PF01926.23 ELR19704.1 - 0.0024 18.0 0.0 0.013 15.5 0.0 2.2 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_22 PF13401.6 ELR19704.1 - 0.0024 18.2 0.0 0.0066 16.7 0.0 1.8 1 0 0 1 1 1 1 AAA domain IstB_IS21 PF01695.17 ELR19704.1 - 0.0054 16.5 0.0 0.011 15.5 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein ArsA_ATPase PF02374.15 ELR19704.1 - 0.0064 15.7 0.0 0.015 14.5 0.0 1.5 1 0 0 1 1 1 1 Anion-transporting ATPase AAA_33 PF13671.6 ELR19704.1 - 0.0087 16.2 0.1 0.028 14.6 0.0 1.9 2 0 0 2 2 2 1 AAA domain ParA PF10609.9 ELR19704.1 - 0.012 15.1 0.1 0.18 11.3 0.0 2.1 2 0 0 2 2 2 0 NUBPL iron-transfer P-loop NTPase AAA_30 PF13604.6 ELR19704.1 - 0.013 15.2 0.2 0.046 13.4 0.0 1.9 2 0 0 2 2 2 0 AAA domain NTPase_1 PF03266.15 ELR19704.1 - 0.021 14.8 0.0 0.035 14.0 0.0 1.4 1 0 0 1 1 1 0 NTPase AAA_29 PF13555.6 ELR19704.1 - 0.022 14.5 0.0 0.049 13.4 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_16 PF13191.6 ELR19704.1 - 0.036 14.4 0.2 0.12 12.8 0.1 1.9 1 1 0 1 1 1 0 AAA ATPase domain RsgA_GTPase PF03193.16 ELR19704.1 - 0.045 13.7 0.0 0.78 9.6 0.0 2.3 2 0 0 2 2 2 0 RsgA GTPase RNA_helicase PF00910.22 ELR19704.1 - 0.063 13.7 0.0 0.15 12.5 0.0 1.7 1 0 0 1 1 1 0 RNA helicase ABC_tran PF00005.27 ELR19704.1 - 0.074 13.6 0.2 0.19 12.2 0.0 1.7 2 0 0 2 2 1 0 ABC transporter AAA PF00004.29 ELR19704.1 - 0.081 13.4 0.0 0.21 12.0 0.0 1.7 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) KAP_NTPase PF07693.14 ELR19704.1 - 0.13 11.5 0.0 0.19 10.9 0.0 1.3 1 0 0 1 1 1 0 KAP family P-loop domain CbiA PF01656.23 ELR19704.1 - 0.15 12.1 0.0 0.46 10.5 0.0 1.7 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain CLP1_P PF16575.5 ELR19704.1 - 0.16 11.8 0.0 0.3 10.8 0.0 1.4 1 0 0 1 1 1 0 mRNA cleavage and polyadenylation factor CLP1 P-loop Pkinase_Tyr PF07714.17 ELR19705.1 - 1.4e-59 201.5 0.0 1.8e-59 201.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ELR19705.1 - 3.5e-51 174.1 0.0 4.9e-51 173.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain SH2 PF00017.24 ELR19705.1 - 2.5e-11 43.5 0.0 4.8e-11 42.6 0.0 1.4 1 0 0 1 1 1 1 SH2 domain APH PF01636.23 ELR19705.1 - 7.5e-05 22.8 0.0 0.00011 22.2 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Herpes_BLLF1 PF05109.13 ELR19705.1 - 0.013 13.5 7.7 0.017 13.2 7.7 1.1 1 0 0 1 1 1 0 Herpes virus major outer envelope glycoprotein (BLLF1) Seadorna_VP7 PF07387.11 ELR19705.1 - 0.085 11.9 0.1 0.14 11.2 0.1 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 Haspin_kinase PF12330.8 ELR19705.1 - 0.11 11.5 0.0 0.19 10.6 0.0 1.3 1 0 0 1 1 1 0 Haspin like kinase domain Pkinase_fungal PF17667.1 ELR19705.1 - 0.19 10.5 0.0 0.31 9.8 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase LELP1 PF15042.6 ELR19705.1 - 9.1 6.7 12.1 11 6.5 7.8 2.4 2 0 0 2 2 2 0 Late cornified envelope-like proline-rich protein 1 Pkinase PF00069.25 ELR19706.1 - 7.6e-48 163.2 0.0 9.5e-48 162.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR19706.1 - 4.1e-25 88.5 0.0 6e-25 88.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 ELR19706.1 - 0.00094 18.6 0.0 0.0016 17.9 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family PARP PF00644.20 ELR19708.1 - 2.1e-63 213.5 0.0 4.4e-63 212.4 0.0 1.6 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain PARP_reg PF02877.14 ELR19708.1 - 6.6e-42 142.8 0.1 1.2e-41 142.0 0.1 1.4 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase, regulatory domain PADR1 PF08063.12 ELR19708.1 - 1.2e-17 63.4 1.5 2.5e-17 62.4 1.5 1.5 1 0 0 1 1 1 1 PADR1 (NUC008) domain zf-PARP PF00645.18 ELR19708.1 - 2.7e-15 57.0 0.3 8.1e-15 55.5 0.3 1.9 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region WGR PF05406.15 ELR19708.1 - 2.4e-10 40.3 3.6 6.1e-06 26.2 0.9 3.0 2 0 0 2 2 2 2 WGR domain WWE PF02825.20 ELR19708.1 - 3.9e-10 40.2 10.5 3.3e-07 30.8 2.2 3.3 3 0 0 3 3 3 2 WWE domain Nucleo_P87 PF07267.11 ELR19708.1 - 0.0016 17.4 2.7 0.0016 17.4 2.7 3.3 3 0 0 3 3 3 1 Nucleopolyhedrovirus capsid protein P87 Myc_N PF01056.18 ELR19708.1 - 0.011 15.7 3.1 0.011 15.7 3.1 2.9 3 0 0 3 3 3 0 Myc amino-terminal region DUF3450 PF11932.8 ELR19708.1 - 0.049 12.9 0.2 0.049 12.9 0.2 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) FYDLN_acid PF09538.10 ELR19708.1 - 0.54 11.0 42.5 0.16 12.7 2.9 4.9 4 0 0 4 4 4 0 Protein of unknown function (FYDLN_acid) DUF2206 PF09971.9 ELR19709.1 - 1.4 7.6 13.8 0.13 10.9 9.5 1.4 2 0 0 2 2 2 0 Predicted membrane protein (DUF2206) TPR_1 PF00515.28 ELR19710.1 - 1.6e-16 59.3 4.2 0.00012 21.7 0.2 3.6 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 ELR19710.1 - 6.3e-14 50.9 5.7 0.00015 21.6 0.8 3.7 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_11 PF13414.6 ELR19710.1 - 2.5e-11 43.1 0.3 0.00018 21.1 0.1 2.8 2 1 1 3 3 3 2 TPR repeat TPR_17 PF13431.6 ELR19710.1 - 1.5e-07 31.3 0.4 0.28 11.6 0.0 3.7 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 ELR19710.1 - 4.9e-06 26.3 1.2 0.051 13.8 0.1 3.7 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.6 ELR19710.1 - 6.8e-05 23.4 1.5 1 10.4 3.9 3.3 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_16 PF13432.6 ELR19710.1 - 0.0013 19.3 0.6 3.5 8.4 0.0 2.5 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_19 PF14559.6 ELR19710.1 - 0.017 15.6 0.5 0.32 11.5 0.3 2.5 2 1 0 2 2 2 0 Tetratricopeptide repeat TPR_9 PF13371.6 ELR19710.1 - 0.02 15.0 2.0 3 8.0 4.2 2.3 1 1 0 2 2 2 0 Tetratricopeptide repeat TPR_7 PF13176.6 ELR19710.1 - 0.026 14.5 0.2 0.69 10.1 0.0 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_6 PF13174.6 ELR19710.1 - 0.078 13.6 0.2 5.2 7.9 0.2 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat GT-D PF08759.11 ELR19710.1 - 0.1 12.3 0.0 0.17 11.5 0.0 1.3 1 0 0 1 1 1 0 Glycosyltransferase GT-D fold TPR_10 PF13374.6 ELR19710.1 - 0.4 10.6 2.1 13 5.8 1.1 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF3439 PF11921.8 ELR19711.1 - 0.053 13.5 4.7 0.14 12.1 4.7 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) PBP1_TM PF14812.6 ELR19711.1 - 0.52 10.7 29.0 0.49 10.8 8.0 3.7 3 0 0 3 3 3 0 Transmembrane domain of transglycosylase PBP1 at N-terminal TetR_C_21 PF17926.1 ELR19711.1 - 1.8 8.8 11.0 4.8 7.3 0.5 3.4 2 1 1 3 3 3 0 Tetracyclin repressor-like, C-terminal domain Flavin_Reduct PF01613.18 ELR19712.1 - 1.2e-15 57.9 0.0 1.4e-15 57.7 0.0 1.1 1 0 0 1 1 1 1 Flavin reductase like domain SET_assoc PF11767.8 ELR19712.1 - 0.2 11.3 0.0 0.33 10.6 0.0 1.3 1 0 0 1 1 1 0 Histone lysine methyltransferase SET associated Ninjurin PF04923.12 ELR19713.1 - 0.015 15.3 0.0 0.028 14.3 0.0 1.4 1 0 0 1 1 1 0 Ninjurin Tweety PF04906.13 ELR19713.1 - 0.051 12.2 1.9 0.08 11.6 1.9 1.3 1 0 0 1 1 1 0 Tweety DUF2254 PF10011.9 ELR19713.1 - 0.093 11.5 0.6 0.2 10.4 0.6 1.5 1 0 0 1 1 1 0 Predicted membrane protein (DUF2254) Pro-kuma_activ PF09286.11 ELR19714.1 - 9.4e-29 100.5 0.0 1.7e-28 99.7 0.0 1.4 1 0 0 1 1 1 1 Pro-kumamolisin, activation domain Peptidase_S8 PF00082.22 ELR19714.1 - 0.011 15.0 0.1 0.017 14.4 0.1 1.2 1 0 0 1 1 1 0 Subtilase family RhoGAP PF00620.27 ELR19715.1 - 1.9e-23 83.0 0.0 5e-23 81.6 0.0 1.7 2 0 0 2 2 2 1 RhoGAP domain FYVE PF01363.21 ELR19715.1 - 0.0047 17.0 0.3 0.011 15.9 0.3 1.7 1 0 0 1 1 1 1 FYVE zinc finger SH3_1 PF00018.28 ELR19716.1 - 7.5e-15 54.3 0.1 1.2e-14 53.6 0.1 1.4 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 ELR19716.1 - 2.1e-13 49.9 0.1 3.3e-13 49.2 0.1 1.3 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 ELR19716.1 - 1.1e-12 47.4 0.0 1.9e-12 46.6 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain CS PF04969.16 ELR19716.1 - 1.9e-08 35.2 0.0 3.4e-08 34.4 0.0 1.4 1 0 0 1 1 1 1 CS domain Glutaminase PF04960.15 ELR19717.1 - 8.5e-41 140.0 0.0 1.3e-40 139.4 0.0 1.1 1 0 0 1 1 1 1 Glutaminase SH3_9 PF14604.6 ELR19717.1 - 3.2e-16 58.9 0.2 6e-16 58.0 0.2 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 ELR19717.1 - 4.2e-16 58.3 0.3 7.9e-16 57.4 0.3 1.5 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 ELR19717.1 - 3.5e-10 39.4 0.0 7.2e-10 38.4 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain DEAD PF00270.29 ELR19719.1 - 8.5e-47 159.2 0.0 2e-46 158.0 0.0 1.7 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ELR19719.1 - 5.8e-31 107.1 0.0 1.8e-30 105.6 0.0 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain PRKG1_interact PF15898.5 ELR19719.1 - 4.8 8.1 14.2 1.2 10.1 5.0 3.1 2 0 0 2 2 2 0 cGMP-dependent protein kinase interacting domain eIF-5_eIF-2B PF01873.17 ELR19722.1 - 1.2e-32 112.2 0.0 2e-32 111.5 0.0 1.3 1 0 0 1 1 1 1 Domain found in IF2B/IF5 A_deamin PF02137.18 ELR19722.1 - 0.063 12.7 0.0 0.11 11.9 0.0 1.3 1 0 0 1 1 1 0 Adenosine-deaminase (editase) domain Asp_Arg_Hydrox PF05118.15 ELR19723.1 - 7.2e-36 123.4 0.0 1.1e-35 122.8 0.0 1.3 1 0 0 1 1 1 1 Aspartyl/Asparaginyl beta-hydroxylase DUF2418 PF10332.9 ELR19724.1 - 8e-13 48.7 1.6 1.5e-12 47.9 1.6 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2418) Reticulon PF02453.17 ELR19724.1 - 0.0026 17.7 1.2 0.051 13.5 0.3 2.1 2 0 0 2 2 2 1 Reticulon OPT PF03169.15 ELR19724.1 - 0.013 14.2 1.6 0.076 11.6 0.0 2.0 2 0 0 2 2 2 0 OPT oligopeptide transporter protein Pex24p PF06398.11 ELR19724.1 - 0.28 10.1 2.3 0.54 9.2 0.1 2.0 2 0 0 2 2 2 0 Integral peroxisomal membrane peroxin FBPase PF00316.20 ELR19725.1 - 5.6e-71 237.9 0.5 7.6e-71 237.5 0.5 1.2 1 0 0 1 1 1 1 Fructose-1-6-bisphosphatase, N-terminal domain Inositol_P PF00459.25 ELR19725.1 - 0.0013 18.3 0.0 0.0026 17.3 0.0 1.5 1 0 0 1 1 1 1 Inositol monophosphatase family tRNA_NucTransf2 PF09249.11 ELR19725.1 - 0.034 14.4 0.0 0.058 13.6 0.0 1.3 1 0 0 1 1 1 0 tRNA nucleotidyltransferase, second domain PLDc PF00614.22 ELR19727.1 - 4.4e-18 64.7 1.1 5.5e-10 39.0 0.1 3.0 3 0 0 3 3 3 2 Phospholipase D Active site motif PLDc_2 PF13091.6 ELR19727.1 - 1.4e-14 54.1 0.3 4.2e-07 29.9 0.1 2.7 2 1 0 2 2 2 2 PLD-like domain PH PF00169.29 ELR19727.1 - 1.7e-10 41.4 1.1 2.9e-10 40.6 1.1 1.4 1 0 0 1 1 1 1 PH domain PH_9 PF15410.6 ELR19727.1 - 0.023 15.0 0.2 0.05 14.0 0.2 1.4 1 0 0 1 1 1 0 Pleckstrin homology domain PH_11 PF15413.6 ELR19727.1 - 0.026 14.9 1.0 0.053 14.0 1.0 1.5 1 0 0 1 1 1 0 Pleckstrin homology domain Mito_carr PF00153.27 ELR19728.1 - 3e-09 36.7 0.0 6.1e-09 35.7 0.0 1.5 1 0 0 1 1 1 1 Mitochondrial carrier protein TMEM135_C_rich PF15982.5 ELR19728.1 - 3.2e-06 27.8 2.9 1.7e-05 25.4 2.9 2.1 1 1 0 1 1 1 1 N-terminal cysteine-rich region of Transmembrane protein 135 LRR_8 PF13855.6 ELR19729.1 - 1.9e-23 82.0 12.0 1.4e-09 37.6 0.6 3.3 2 1 1 3 3 3 3 Leucine rich repeat LRR_4 PF12799.7 ELR19729.1 - 4.9e-21 74.5 32.3 3.4e-06 27.3 0.5 5.0 1 1 3 5 5 5 5 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 ELR19729.1 - 2.2e-08 33.5 18.7 0.83 10.4 0.5 7.5 8 0 0 8 8 8 3 Leucine Rich Repeat LRR_6 PF13516.6 ELR19729.1 - 6.8e-08 32.0 25.2 0.34 11.1 0.3 7.8 8 0 0 8 8 8 5 Leucine Rich repeat DASH_Dam1 PF08653.10 ELR19729.1 - 0.075 12.8 0.2 17 5.3 0.0 3.0 3 0 0 3 3 3 0 DASH complex subunit Dam1 Ank_2 PF12796.7 ELR19730.1 - 5.4e-22 78.2 13.1 1.7e-09 38.1 0.1 4.2 1 1 4 5 5 5 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ELR19730.1 - 2.2e-15 56.8 11.8 1.6e-07 31.7 0.1 5.6 5 2 0 5 5 5 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 ELR19730.1 - 4.9e-14 51.1 9.5 0.042 14.4 0.0 7.3 7 0 0 7 7 7 4 Ankyrin repeat F-box-like PF12937.7 ELR19730.1 - 1.8e-08 34.1 1.4 4.2e-08 33.0 1.4 1.7 1 0 0 1 1 1 1 F-box-like Ank_5 PF13857.6 ELR19730.1 - 3.2e-07 30.5 12.1 0.15 12.5 0.1 6.3 5 1 1 6 6 6 3 Ankyrin repeats (many copies) Ank PF00023.30 ELR19730.1 - 2.6e-06 27.6 16.5 0.39 11.3 0.0 6.6 6 0 0 6 6 6 1 Ankyrin repeat F-box PF00646.33 ELR19730.1 - 0.00016 21.4 3.2 0.00037 20.3 0.8 2.4 2 0 0 2 2 2 1 F-box domain TFIIF_alpha PF05793.12 ELR19730.1 - 0.00051 18.8 21.2 0.00069 18.3 21.2 1.1 1 0 0 1 1 1 1 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) SDA1 PF05285.12 ELR19730.1 - 0.0019 17.7 19.7 0.0035 16.8 19.7 1.4 1 0 0 1 1 1 1 SDA1 SR-25 PF10500.9 ELR19730.1 - 0.014 15.0 21.4 0.024 14.2 21.4 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Macoilin PF09726.9 ELR19730.1 - 0.16 10.5 11.4 0.23 10.0 11.4 1.1 1 0 0 1 1 1 0 Macoilin family Nop14 PF04147.12 ELR19730.1 - 0.25 9.5 23.8 0.34 9.1 23.8 1.1 1 0 0 1 1 1 0 Nop14-like family MAJIN PF15077.6 ELR19730.1 - 0.26 11.0 11.8 0.47 10.2 11.8 1.4 1 0 0 1 1 1 0 Membrane-anchored junction protein DUF3827 PF12877.7 ELR19730.1 - 0.34 9.2 13.0 0.47 8.8 13.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3827) PA26 PF04636.13 ELR19730.1 - 0.56 9.1 3.6 0.87 8.4 3.6 1.3 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Mpp10 PF04006.12 ELR19730.1 - 0.58 8.5 26.9 0.8 8.1 26.9 1.1 1 0 0 1 1 1 0 Mpp10 protein eIF-3c_N PF05470.12 ELR19730.1 - 0.8 7.9 14.1 1.1 7.5 14.1 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 8 N-terminus ORC6 PF05460.13 ELR19730.1 - 1 8.6 13.5 1.7 7.8 13.5 1.3 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) SLC12 PF03522.15 ELR19730.1 - 1.1 8.2 12.5 1.7 7.6 12.5 1.2 1 0 0 1 1 1 0 Solute carrier family 12 Vfa1 PF08432.10 ELR19730.1 - 1.3 9.4 19.0 2.8 8.2 19.0 1.6 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 CDC45 PF02724.14 ELR19730.1 - 1.5 7.1 26.7 2.3 6.4 26.7 1.2 1 0 0 1 1 1 0 CDC45-like protein Apt1 PF10351.9 ELR19730.1 - 2.8 6.7 14.6 4.2 6.1 14.6 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain Presenilin PF01080.17 ELR19730.1 - 4.1 6.0 18.4 6.2 5.5 18.4 1.1 1 0 0 1 1 1 0 Presenilin ALMT PF11744.8 ELR19730.1 - 4.5 6.0 8.4 6.6 5.4 8.4 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter RR_TM4-6 PF06459.12 ELR19730.1 - 6.6 6.5 19.4 10 5.8 19.4 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 SAPS PF04499.15 ELR19730.1 - 7.3 5.3 15.0 10 4.8 15.0 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein SOBP PF15279.6 ELR19730.1 - 8.2 6.9 8.0 12 6.3 8.0 1.3 1 0 0 1 1 1 0 Sine oculis-binding protein Bgal_small_N PF02929.17 ELR19731.1 - 7e-58 196.1 0.0 1e-57 195.5 0.0 1.2 1 0 0 1 1 1 1 Beta galactosidase small chain Glyco_hydro_2_C PF02836.17 ELR19731.1 - 1.3e-43 149.3 0.0 4.3e-21 75.3 0.0 2.2 1 1 1 2 2 2 2 Glycosyl hydrolases family 2, TIM barrel domain DUF4981 PF16353.5 ELR19731.1 - 2.1e-21 76.2 0.0 4.1e-21 75.2 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function(DUF4981) Glyco_hydro_2_C PF02836.17 ELR19732.1 - 4.6e-27 94.9 0.7 6.1e-20 71.5 0.1 2.4 3 0 0 3 3 3 2 Glycosyl hydrolases family 2, TIM barrel domain Glyco_hydro_2 PF00703.21 ELR19732.1 - 0.0031 18.2 0.0 0.0056 17.3 0.0 1.5 1 0 0 1 1 1 1 Glycosyl hydrolases family 2 Glyco_hydro_2_N PF02837.18 ELR19733.1 - 6e-30 104.4 0.0 8.3e-30 103.9 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, sugar binding domain TPR_1 PF00515.28 ELR19734.1 - 5e-27 92.6 20.3 7.1e-08 32.0 0.3 8.6 8 1 0 8 8 8 6 Tetratricopeptide repeat TPR_2 PF07719.17 ELR19734.1 - 2.8e-24 83.2 17.4 0.00074 19.5 0.5 8.0 9 0 0 9 9 7 7 Tetratricopeptide repeat TPR_17 PF13431.6 ELR19734.1 - 6.9e-22 76.2 4.7 0.0027 18.0 0.0 7.6 6 2 1 7 7 7 5 Tetratricopeptide repeat TPR_11 PF13414.6 ELR19734.1 - 2.9e-19 68.5 19.1 0.00029 20.5 0.3 7.3 4 2 3 7 7 7 5 TPR repeat TPR_9 PF13371.6 ELR19734.1 - 6.5e-16 58.2 6.4 0.0078 16.3 0.7 5.4 2 1 3 5 5 5 4 Tetratricopeptide repeat TPR_8 PF13181.6 ELR19734.1 - 1.1e-15 56.5 8.6 0.029 14.6 0.0 7.5 8 0 0 8 8 8 4 Tetratricopeptide repeat TPR_14 PF13428.6 ELR19734.1 - 1.7e-15 56.4 5.8 0.2 12.6 0.1 7.3 3 1 4 7 7 7 5 Tetratricopeptide repeat TPR_16 PF13432.6 ELR19734.1 - 2.5e-14 53.6 10.8 0.0046 17.6 0.1 5.8 3 1 2 6 6 6 5 Tetratricopeptide repeat TPR_19 PF14559.6 ELR19734.1 - 3e-09 37.3 2.9 0.75 10.4 0.0 5.3 3 1 1 5 5 5 1 Tetratricopeptide repeat TPR_12 PF13424.6 ELR19734.1 - 2.1e-07 31.1 9.5 0.00012 22.2 0.8 5.1 4 2 1 5 5 5 1 Tetratricopeptide repeat TPR_7 PF13176.6 ELR19734.1 - 1.1e-06 28.3 5.9 0.0054 16.7 0.1 5.7 7 1 0 7 7 7 1 Tetratricopeptide repeat SHNi-TPR PF10516.9 ELR19734.1 - 4.7e-05 22.7 1.1 1.4 8.4 0.0 4.9 5 0 0 5 5 5 2 SHNi-TPR TPR_20 PF14561.6 ELR19734.1 - 7.7e-05 22.9 0.1 1.7 9.0 0.0 3.6 2 1 1 3 3 3 1 Tetratricopeptide repeat NARP1 PF12569.8 ELR19734.1 - 0.00012 21.2 0.3 0.084 11.8 0.0 2.7 3 0 0 3 3 3 2 NMDA receptor-regulated protein 1 TPR_6 PF13174.6 ELR19734.1 - 0.00018 21.9 3.7 22 6.0 0.0 5.4 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_15 PF13429.6 ELR19734.1 - 0.00025 20.4 0.5 0.8 8.9 0.0 3.4 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_10 PF13374.6 ELR19734.1 - 0.00054 19.7 21.2 0.0013 18.5 1.1 5.9 7 0 0 7 7 7 2 Tetratricopeptide repeat BTAD PF03704.17 ELR19734.1 - 0.0058 17.1 3.2 4.3 7.8 0.0 3.8 1 1 3 4 4 4 1 Bacterial transcriptional activator domain Fis1_TPR_C PF14853.6 ELR19734.1 - 0.15 12.2 1.6 18 5.5 0.2 3.4 3 0 0 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat PDEase_I PF00233.19 ELR19734.1 - 0.2 11.3 0.0 0.33 10.6 0.0 1.3 1 0 0 1 1 1 0 3'5'-cyclic nucleotide phosphodiesterase ATG27 PF09451.10 ELR19735.1 - 2e-17 64.0 0.0 7.3e-17 62.1 0.0 1.7 1 1 0 1 1 1 1 Autophagy-related protein 27 Man-6-P_recep PF02157.15 ELR19735.1 - 1.1e-09 37.8 0.1 1.9e-09 37.0 0.1 1.3 1 0 0 1 1 1 1 Mannose-6-phosphate receptor CIMR PF00878.18 ELR19735.1 - 0.00023 21.2 0.8 0.052 13.6 0.0 2.3 2 0 0 2 2 2 2 Cation-independent mannose-6-phosphate receptor repeat GTP_EFTU PF00009.27 ELR19736.1 - 1.1e-50 171.9 0.0 2.1e-50 170.9 0.0 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 ELR19736.1 - 7.3e-38 129.3 0.0 1.3e-37 128.5 0.0 1.4 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain MMR_HSR1 PF01926.23 ELR19736.1 - 3.1e-06 27.3 0.1 9.4e-05 22.5 0.1 2.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 ELR19736.1 - 0.074 12.4 0.0 0.13 11.6 0.0 1.4 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region Amelogenin PF02948.15 ELR19736.1 - 0.11 13.1 0.1 0.17 12.5 0.1 1.2 1 0 0 1 1 1 0 Amelogenin Pkinase PF00069.25 ELR19738.1 - 1.3e-60 205.0 0.0 1.7e-60 204.7 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR19738.1 - 4.2e-31 108.2 0.0 5.3e-31 107.8 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 ELR19738.1 - 2.5e-07 30.2 0.0 4e-07 29.6 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 ELR19738.1 - 1.6e-05 24.9 0.2 0.014 15.3 0.0 2.3 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kinase-like PF14531.6 ELR19738.1 - 0.0054 16.1 0.0 0.021 14.2 0.0 1.8 1 1 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 ELR19738.1 - 0.057 12.2 0.0 0.069 11.9 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase EF-hand_1 PF00036.32 ELR19739.1 - 1.5e-20 71.1 12.9 2.6e-07 29.7 0.0 7.2 8 0 0 8 8 8 4 EF hand EF-hand_7 PF13499.6 ELR19739.1 - 1.8e-19 69.9 4.8 9e-07 29.3 0.1 5.8 4 1 0 4 4 4 4 EF-hand domain pair EF-hand_6 PF13405.6 ELR19739.1 - 2e-18 64.7 6.8 6.9e-07 28.7 0.0 7.5 7 1 1 8 8 8 2 EF-hand domain EF-hand_5 PF13202.6 ELR19739.1 - 1.1e-12 46.9 10.4 1.5e-07 30.6 0.1 5.2 5 0 0 5 5 5 2 EF hand EF-hand_8 PF13833.6 ELR19739.1 - 1.9e-09 37.2 9.0 0.0074 16.1 0.0 5.5 5 1 1 6 6 6 3 EF-hand domain pair EF-hand_4 PF12763.7 ELR19739.1 - 0.014 15.3 0.5 6.5 6.8 0.0 3.6 3 1 1 4 4 4 0 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 ELR19739.1 - 0.071 13.4 0.1 25 5.2 0.0 3.2 2 1 0 3 3 3 0 Secreted protein acidic and rich in cysteine Ca binding region Peptidase_C2 PF00648.21 ELR19739.1 - 0.1 11.6 0.5 0.18 10.8 0.5 1.3 1 0 0 1 1 1 0 Calpain family cysteine protease Abhydrolase_1 PF00561.20 ELR19740.1 - 2.2e-08 34.1 0.1 3.5e-08 33.4 0.1 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 ELR19740.1 - 1.8e-06 27.4 0.0 3.3e-06 26.6 0.0 1.4 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 ELR19740.1 - 6.5e-06 26.9 0.3 1.1e-05 26.1 0.3 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family VirJ PF06057.11 ELR19740.1 - 0.11 12.4 0.0 0.18 11.7 0.0 1.3 1 0 0 1 1 1 0 Bacterial virulence protein (VirJ) CDT1 PF08839.11 ELR19741.1 - 0.039 14.2 0.0 0.048 14.0 0.0 1.0 1 0 0 1 1 1 0 DNA replication factor CDT1 like EF-hand_1 PF00036.32 ELR19742.1 - 1.5e-20 71.1 12.9 2.6e-07 29.7 0.0 7.2 8 0 0 8 8 8 4 EF hand EF-hand_7 PF13499.6 ELR19742.1 - 1.8e-19 69.9 4.8 9e-07 29.3 0.1 5.8 4 1 0 4 4 4 4 EF-hand domain pair EF-hand_6 PF13405.6 ELR19742.1 - 2e-18 64.7 6.8 6.9e-07 28.7 0.0 7.5 7 1 1 8 8 8 2 EF-hand domain EF-hand_5 PF13202.6 ELR19742.1 - 1.1e-12 46.9 10.4 1.5e-07 30.6 0.1 5.2 5 0 0 5 5 5 2 EF hand EF-hand_8 PF13833.6 ELR19742.1 - 1.9e-09 37.2 9.0 0.0074 16.1 0.0 5.5 5 1 1 6 6 6 3 EF-hand domain pair EF-hand_4 PF12763.7 ELR19742.1 - 0.014 15.3 0.5 6.5 6.8 0.0 3.6 3 1 1 4 4 4 0 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 ELR19742.1 - 0.071 13.4 0.1 25 5.2 0.0 3.2 2 1 0 3 3 3 0 Secreted protein acidic and rich in cysteine Ca binding region Peptidase_C2 PF00648.21 ELR19742.1 - 0.1 11.6 0.5 0.18 10.8 0.5 1.3 1 0 0 1 1 1 0 Calpain family cysteine protease 2OG-FeII_Oxy_3 PF13640.6 ELR19744.1 - 0.00075 20.3 0.0 0.0014 19.5 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy PF03171.20 ELR19744.1 - 0.13 12.8 0.0 0.2 12.1 0.0 1.4 1 0 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily NifW PF03206.14 ELR19745.1 - 0.4 11.2 5.7 0.46 11.0 4.4 1.8 1 1 0 1 1 1 0 Nitrogen fixation protein NifW Connexin PF00029.19 ELR19745.1 - 0.79 9.4 2.7 1.5 8.5 2.7 1.4 1 0 0 1 1 1 0 Connexin Ras PF00071.22 ELR19746.1 - 2.2e-36 124.9 0.0 3.1e-36 124.4 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR19746.1 - 2.9e-14 53.3 0.0 4.2e-14 52.8 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase F-box-like PF12937.7 ELR19746.1 - 1.2e-08 34.7 0.4 3e-08 33.4 0.4 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ELR19746.1 - 4.2e-06 26.5 0.1 1e-05 25.3 0.1 1.7 1 0 0 1 1 1 1 F-box domain Arf PF00025.21 ELR19746.1 - 0.00076 19.0 0.0 0.0011 18.4 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 ELR19746.1 - 0.0067 16.5 0.0 0.01 15.9 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase DUF2288 PF10052.9 ELR19746.1 - 0.097 12.8 0.0 0.21 11.7 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2288) VirE PF05272.11 ELR19746.1 - 0.15 11.8 0.0 0.24 11.1 0.0 1.3 1 0 0 1 1 1 0 Virulence-associated protein E Hpr_kinase_C PF07475.12 ELR19746.1 - 0.19 11.2 0.0 0.77 9.3 0.0 1.8 2 0 0 2 2 2 0 HPr Serine kinase C-terminal domain Laminin_G_3 PF13385.6 ELR19747.1 - 9.8e-15 55.0 0.0 4.2e-14 53.0 0.0 2.1 2 1 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily PEGA PF08308.11 ELR19747.1 - 0.13 12.1 0.0 22 5.0 0.0 2.6 2 0 0 2 2 2 0 PEGA domain DUF898 PF05987.13 ELR19749.1 - 0.072 12.1 0.0 0.13 11.3 0.0 1.3 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF898) Rsm22 PF09243.10 ELR19750.1 - 0.12 11.7 0.0 0.14 11.4 0.0 1.1 1 0 0 1 1 1 0 Mitochondrial small ribosomal subunit Rsm22 Rsm22 PF09243.10 ELR19751.1 - 0.11 11.7 0.0 0.13 11.5 0.0 1.1 1 0 0 1 1 1 0 Mitochondrial small ribosomal subunit Rsm22 Rsm22 PF09243.10 ELR19752.1 - 0.1 11.9 0.0 0.12 11.6 0.0 1.1 1 0 0 1 1 1 0 Mitochondrial small ribosomal subunit Rsm22 Transferase PF02458.15 ELR19753.1 - 2.8e-11 42.7 0.0 8.6e-08 31.3 0.0 2.1 2 0 0 2 2 2 2 Transferase family Adeno_PV PF03910.13 ELR19753.1 - 0.84 8.3 4.4 0.92 8.1 4.4 1.1 1 0 0 1 1 1 0 Adenovirus minor core protein PV F-box-like PF12937.7 ELR19756.1 - 0.043 13.7 0.1 0.14 12.1 0.1 1.9 1 0 0 1 1 1 0 F-box-like F-box PF00646.33 ELR19756.1 - 0.093 12.6 0.1 0.21 11.5 0.1 1.6 1 0 0 1 1 1 0 F-box domain YL1 PF05764.13 ELR19756.1 - 3.2 7.8 28.8 1.9 8.5 9.2 3.3 3 0 0 3 3 3 0 YL1 nuclear protein RNase_T PF00929.24 ELR19757.1 - 0.046 14.3 0.0 0.13 12.8 0.0 1.8 1 1 0 1 1 1 0 Exonuclease DCA16 PF15349.6 ELR19757.1 - 0.17 11.4 1.0 0.21 11.1 0.4 1.4 2 0 0 2 2 2 0 DDB1- and CUL4-associated factor 16 FAM176 PF14851.6 ELR19757.1 - 0.91 9.2 4.4 1.4 8.6 4.4 1.2 1 0 0 1 1 1 0 FAM176 family RasGEF PF00617.19 ELR19758.1 - 2e-46 158.4 0.3 3.4e-46 157.7 0.3 1.4 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 ELR19758.1 - 2.2e-07 31.0 0.4 5.8e-07 29.7 0.4 1.7 1 0 0 1 1 1 1 RasGEF N-terminal motif DUF1115 PF06544.12 ELR19759.1 - 8.8e-11 42.1 0.0 1.6e-10 41.3 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1115) RWD PF05773.22 ELR19759.1 - 7.4e-10 39.1 0.0 1.2e-09 38.5 0.0 1.3 1 0 0 1 1 1 1 RWD domain Mito_carr PF00153.27 ELR19760.1 - 0.003 17.4 0.0 0.037 14.0 0.0 2.6 3 0 0 3 3 3 1 Mitochondrial carrier protein Exo_endo_phos PF03372.23 ELR19761.1 - 5.2e-09 36.0 0.0 7.8e-09 35.4 0.0 1.2 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family DUF5051 PF16473.5 ELR19761.1 - 0.057 13.4 0.0 0.082 12.9 0.0 1.3 1 0 0 1 1 1 0 3' exoribonuclease, RNase T-like Ras PF00071.22 ELR19762.1 - 1.5e-47 161.2 0.0 2.3e-47 160.6 0.0 1.3 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR19762.1 - 2.6e-27 95.4 0.0 4.7e-27 94.6 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ank_5 PF13857.6 ELR19762.1 - 1.4e-16 60.3 0.7 7.6e-08 32.5 0.0 3.4 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 ELR19762.1 - 7.5e-16 58.5 0.0 9.2e-14 51.8 0.0 2.4 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank PF00023.30 ELR19762.1 - 1.1e-15 57.3 1.7 3e-06 27.4 0.1 3.9 3 0 0 3 3 3 3 Ankyrin repeat Ank_3 PF13606.6 ELR19762.1 - 1.3e-14 52.8 0.5 0.00024 21.3 0.0 4.1 4 0 0 4 4 3 3 Ankyrin repeat Ank_4 PF13637.6 ELR19762.1 - 3.1e-14 53.1 0.0 5.5e-10 39.6 0.0 3.4 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Arf PF00025.21 ELR19762.1 - 1.4e-09 37.6 0.0 2.2e-09 37.0 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family F-box-like PF12937.7 ELR19762.1 - 4.6e-06 26.4 0.1 7.9e-06 25.7 0.1 1.4 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ELR19762.1 - 0.00012 21.8 0.2 0.00023 20.9 0.2 1.5 1 0 0 1 1 1 1 F-box domain F-box_4 PF15966.5 ELR19762.1 - 0.00014 21.7 0.1 0.00028 20.8 0.1 1.5 1 0 0 1 1 1 1 F-box Gtr1_RagA PF04670.12 ELR19762.1 - 0.0041 16.5 0.0 0.0061 15.9 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region AAA_22 PF13401.6 ELR19762.1 - 0.023 14.9 0.0 0.16 12.2 0.0 2.1 1 1 0 1 1 1 0 AAA domain AAA_7 PF12775.7 ELR19762.1 - 0.25 10.8 0.0 0.41 10.1 0.0 1.2 1 0 0 1 1 1 0 P-loop containing dynein motor region Gal_Lectin PF02140.18 ELR19763.1 - 1.2e-64 214.7 11.7 4.2e-16 59.1 0.5 4.1 4 0 0 4 4 4 4 Galactose binding lectin domain BAF250_C PF12031.8 ELR19765.1 - 0.2 10.9 0.0 0.29 10.4 0.0 1.2 1 0 0 1 1 1 0 SWI/SNF-like complex subunit BAF250/Osa Pkinase PF00069.25 ELR19766.1 - 1.7e-28 99.7 0.0 4.2e-28 98.5 0.0 1.6 1 0 0 1 1 1 1 Protein kinase domain DSPc PF00782.20 ELR19766.1 - 2.5e-12 46.8 1.7 1.3e-11 44.5 0.8 2.3 2 0 0 2 2 2 1 Dual specificity phosphatase, catalytic domain Pkinase_Tyr PF07714.17 ELR19766.1 - 7.9e-12 45.0 0.0 1.4e-11 44.2 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase GST_C_3 PF14497.6 ELR19767.1 - 2.9e-21 75.5 0.0 4.1e-21 75.0 0.0 1.2 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 ELR19767.1 - 6e-11 42.5 0.0 1.1e-10 41.7 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 ELR19767.1 - 2.3e-09 37.3 0.2 5e-09 36.3 0.0 1.8 2 1 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 ELR19767.1 - 0.00013 22.0 0.0 0.00026 20.9 0.0 1.7 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 ELR19767.1 - 0.00026 21.4 0.0 0.00056 20.3 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain RCC1 PF00415.18 ELR19768.1 - 1.7e-47 159.8 5.9 2.2e-09 37.8 0.0 6.9 6 1 0 6 6 6 6 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 ELR19768.1 - 4.2e-32 109.3 19.6 2.4e-07 30.4 0.3 5.3 5 0 0 5 5 5 5 Regulator of chromosome condensation (RCC1) repeat Allantoicase PF03561.15 ELR19769.1 - 1.6e-68 229.2 0.0 9.9e-34 116.4 0.0 2.9 3 0 0 3 3 3 2 Allantoicase repeat Malate_synthase PF01274.22 ELR19769.1 - 5.6e-64 216.3 0.0 1.7e-38 132.2 0.0 2.0 2 0 0 2 2 2 2 Malate synthase HpcH_HpaI PF03328.14 ELR19769.1 - 0.033 13.3 0.0 0.14 11.3 0.0 1.8 2 0 0 2 2 2 0 HpcH/HpaI aldolase/citrate lyase family EMP70 PF02990.16 ELR19771.1 - 2.6e-215 716.0 6.6 3.8e-215 715.5 6.6 1.2 1 0 0 1 1 1 1 Endomembrane protein 70 MFS_1 PF07690.16 ELR19771.1 - 0.00055 19.0 12.1 0.00055 19.0 12.1 3.2 1 1 2 3 3 3 1 Major Facilitator Superfamily Shisa PF13908.6 ELR19771.1 - 0.82 9.9 4.5 13 6.0 0.0 2.8 3 1 0 3 3 3 0 Wnt and FGF inhibitory regulator CBS PF00571.28 ELR19772.1 - 3.2e-16 59.5 0.0 0.00014 22.2 0.0 4.3 4 0 0 4 4 4 3 CBS domain D123 PF07065.14 ELR19773.1 - 3.6e-07 29.6 0.1 5.1e-07 29.1 0.1 1.4 1 1 0 1 1 1 1 D123 Rsm22 PF09243.10 ELR19774.1 - 0.14 11.4 0.0 0.18 11.0 0.0 1.1 1 0 0 1 1 1 0 Mitochondrial small ribosomal subunit Rsm22 Sortilin-Vps10 PF15902.5 ELR19776.1 - 1.9e-05 23.7 2.0 0.02 13.7 0.2 2.8 1 1 3 4 4 4 4 Sortilin, neurotensin receptor 3, PSII_BNR PF14870.6 ELR19776.1 - 6.7e-05 22.3 4.9 0.0092 15.3 3.9 3.0 1 1 1 2 2 2 1 Photosynthesis system II assembly factor YCF48 BNR PF02012.20 ELR19776.1 - 0.0006 19.4 9.9 2.9 8.3 0.0 5.6 5 1 1 6 6 6 2 BNR/Asp-box repeat YDG PF18657.1 ELR19776.1 - 0.15 12.3 0.2 6.8 7.0 0.0 2.6 2 0 0 2 2 2 0 YDG domain Arf PF00025.21 ELR19777.1 - 2e-68 229.3 0.0 2.2e-68 229.1 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.22 ELR19777.1 - 4.2e-16 59.0 0.0 4.7e-16 58.8 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR19777.1 - 9.9e-15 54.8 0.0 1.3e-14 54.4 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 ELR19777.1 - 4.4e-12 45.8 0.0 5.6e-12 45.5 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.20 ELR19777.1 - 2.2e-10 40.3 0.6 4.2e-06 26.2 0.1 2.2 1 1 1 2 2 2 2 G-protein alpha subunit Gtr1_RagA PF04670.12 ELR19777.1 - 2.7e-09 36.7 0.0 3.3e-09 36.4 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 ELR19777.1 - 0.00058 19.5 0.0 0.001 18.6 0.0 1.4 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 ELR19777.1 - 0.0016 18.5 0.0 0.0026 17.8 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase NACHT PF05729.12 ELR19777.1 - 0.0086 16.0 0.3 0.018 14.9 0.1 1.5 1 1 1 2 2 2 1 NACHT domain 6PF2K PF01591.18 ELR19777.1 - 0.031 13.6 0.3 0.25 10.6 0.3 2.0 1 1 0 1 1 1 0 6-phosphofructo-2-kinase AAA_18 PF13238.6 ELR19777.1 - 0.12 13.0 0.1 0.34 11.5 0.1 1.8 1 1 0 1 1 1 0 AAA domain Lipase_3 PF01764.25 ELR19778.1 - 9.4e-21 74.2 0.0 2.1e-20 73.0 0.0 1.5 1 0 0 1 1 1 1 Lipase (class 3) Abhydrolase_6 PF12697.7 ELR19778.1 - 0.0026 18.4 0.2 0.0066 17.1 0.0 1.7 2 0 0 2 2 2 1 Alpha/beta hydrolase family DUF4667 PF15700.5 ELR19778.1 - 0.038 14.1 28.4 0.15 12.1 18.5 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4667) Hydrolase_4 PF12146.8 ELR19778.1 - 0.051 12.8 0.0 0.11 11.8 0.0 1.5 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Thioesterase PF00975.20 ELR19778.1 - 0.085 12.9 1.2 0.15 12.2 0.0 2.0 2 0 0 2 2 2 0 Thioesterase domain Ras PF00071.22 ELR19779.1 - 7.4e-59 198.0 0.1 8.6e-59 197.8 0.1 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR19779.1 - 5.3e-31 107.3 0.1 8.3e-31 106.7 0.1 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR19779.1 - 6.4e-13 48.5 0.0 8.1e-13 48.2 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 ELR19779.1 - 0.00011 22.3 0.0 0.00017 21.6 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 ELR19779.1 - 0.00066 19.3 0.0 0.0019 17.8 0.0 1.7 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 ELR19779.1 - 0.0045 16.4 0.0 0.0052 16.2 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 ELR19779.1 - 0.029 14.3 0.0 8.3 6.3 0.0 2.3 2 0 0 2 2 2 0 RsgA GTPase ADH_N PF08240.12 ELR19780.1 - 8.5e-34 115.7 3.1 1.4e-33 115.0 3.1 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 ELR19780.1 - 1.2e-27 96.5 0.3 1.2e-27 96.5 0.3 1.9 3 0 0 3 3 3 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 ELR19780.1 - 1.8e-06 29.1 0.0 3.2e-06 28.2 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase AlaDh_PNT_C PF01262.21 ELR19780.1 - 0.026 13.8 0.5 0.042 13.1 0.5 1.4 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain ThiF PF00899.21 ELR19780.1 - 0.26 10.6 0.9 0.4 10.0 0.3 1.6 2 0 0 2 2 2 0 ThiF family T5orf172 PF10544.9 ELR19781.1 - 0.093 13.3 7.6 2 9.0 0.3 4.6 3 1 0 4 4 4 0 T5orf172 domain DUF2344 PF10105.9 ELR19781.1 - 2 8.2 5.3 4.5 7.1 0.0 3.4 3 1 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2344) Exo_endo_phos PF03372.23 ELR19782.1 - 4.4e-13 49.3 0.0 1e-12 48.1 0.0 1.6 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.6 ELR19782.1 - 0.037 13.9 0.0 0.12 12.3 0.0 1.9 2 0 0 2 2 2 0 Endonuclease-reverse transcriptase MctB PF11382.8 ELR19782.1 - 0.19 11.4 0.0 0.53 9.9 0.0 1.6 2 0 0 2 2 2 0 Copper transport outer membrane protein, MctB UFD1 PF03152.14 ELR19783.1 - 2e-50 170.6 0.0 2.8e-50 170.2 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin fusion degradation protein UFD1 UQ_con PF00179.26 ELR19783.1 - 5.7e-07 29.3 0.0 1.3e-06 28.1 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme zf-TRAF PF02176.18 ELR19783.1 - 3.2e-06 27.7 2.1 3.2e-06 27.7 2.1 3.5 1 1 2 3 3 3 2 TRAF-type zinc finger zf_UBZ PF18439.1 ELR19783.1 - 0.00059 19.4 19.1 1.4 8.6 0.0 5.7 5 0 0 5 5 5 4 Ubiquitin-Binding Zinc Finger zf_C2H2_13 PF18508.1 ELR19783.1 - 0.045 13.3 0.2 0.045 13.3 0.2 4.4 4 0 0 4 4 4 0 Zinc finger domain PRP21_like_P PF12230.8 ELR19783.1 - 0.42 10.4 3.8 1.4 8.7 0.5 2.5 2 1 0 2 2 2 0 Pre-mRNA splicing factor PRP21 like protein Lyase_8 PF02278.18 ELR19785.1 - 1.9e-65 220.9 0.7 3e-65 220.3 0.1 1.6 2 0 0 2 2 2 1 Polysaccharide lyase family 8, super-sandwich domain Lyase_8_N PF08124.11 ELR19785.1 - 6.8e-23 81.1 0.1 1.2e-22 80.2 0.1 1.3 1 0 0 1 1 1 1 Polysaccharide lyase family 8, N terminal alpha-helical domain Lyase_8_C PF02884.17 ELR19785.1 - 6.8e-18 64.9 0.1 2.2e-17 63.3 0.1 2.0 1 0 0 1 1 1 1 Polysaccharide lyase family 8, C-terminal beta-sandwich domain Lyase_catalyt PF09093.11 ELR19785.1 - 0.0044 16.2 0.1 0.0085 15.3 0.1 1.4 1 0 0 1 1 1 1 Lyase, catalytic PTCRA PF15028.6 ELR19785.1 - 0.28 10.9 4.9 0.081 12.6 0.4 2.3 2 0 0 2 2 2 0 Pre-T-cell antigen receptor WD40 PF00400.32 ELR19786.1 - 1.1e-19 70.4 16.0 1.1e-06 29.3 0.4 6.3 6 1 1 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ELR19786.1 - 3.7e-13 49.6 0.5 3.3e-05 24.1 0.0 3.7 2 1 1 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ELR19786.1 - 1.8e-06 26.9 2.1 0.0082 14.8 0.1 2.7 1 1 2 3 3 3 2 Nucleoporin Nup120/160 Nucleoporin_N PF08801.11 ELR19786.1 - 0.018 13.8 0.0 0.039 12.7 0.0 1.5 1 1 0 1 1 1 0 Nup133 N terminal like Ge1_WD40 PF16529.5 ELR19786.1 - 0.079 11.9 0.1 0.15 11.0 0.1 1.4 1 0 0 1 1 1 0 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ELR19786.1 - 0.11 11.8 0.0 3.4 6.9 0.0 2.5 2 1 0 2 2 2 0 WD40-like domain Cytochrom_D1 PF02239.16 ELR19786.1 - 0.12 10.9 0.0 0.47 8.9 0.0 1.9 2 0 0 2 2 2 0 Cytochrome D1 heme domain Ras PF00071.22 ELR19787.1 - 4.1e-18 65.5 0.2 2.7e-13 49.8 0.1 2.7 2 1 0 2 2 2 2 Ras family Roc PF08477.13 ELR19787.1 - 3.2e-10 40.2 0.1 1.2e-08 35.2 0.1 2.3 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase AAA_16 PF13191.6 ELR19787.1 - 0.026 14.9 2.3 0.11 12.9 2.3 2.0 1 1 0 1 1 1 0 AAA ATPase domain TniB PF05621.11 ELR19787.1 - 0.036 13.5 0.0 0.066 12.6 0.0 1.6 2 1 0 2 2 2 0 Bacterial TniB protein Arf PF00025.21 ELR19787.1 - 0.043 13.3 0.0 0.093 12.2 0.0 1.6 2 0 0 2 2 2 0 ADP-ribosylation factor family PRR20 PF15708.5 ELR19787.1 - 1.7 8.5 8.5 2.3 8.1 8.5 1.2 1 0 0 1 1 1 0 Proline-rich protein family 20 Rrn6 PF10214.9 ELR19787.1 - 4.8 5.6 5.5 5.9 5.2 5.5 1.0 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor Response_reg PF00072.24 ELR19788.1 - 7.5e-27 93.7 2.4 9.4e-23 80.5 0.5 3.5 3 0 0 3 3 3 2 Response regulator receiver domain HATPase_c PF02518.26 ELR19788.1 - 2.2e-24 86.1 0.0 9.9e-19 67.9 0.0 2.5 2 0 0 2 2 2 2 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 ELR19788.1 - 1.7e-18 66.4 0.0 1.6e-17 63.2 0.0 2.5 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain Clavanin PF05452.11 ELR19789.1 - 0.062 13.5 0.0 0.12 12.6 0.0 1.4 1 0 0 1 1 1 0 Clavanin PFK PF00365.20 ELR19790.1 - 7.1e-99 330.7 1.3 8.4e-99 330.5 1.3 1.0 1 0 0 1 1 1 1 Phosphofructokinase NAD_kinase PF01513.21 ELR19790.1 - 0.0018 17.5 0.1 0.0026 17.0 0.1 1.3 1 0 0 1 1 1 1 ATP-NAD kinase DAGK_cat PF00781.24 ELR19790.1 - 0.051 13.2 0.1 0.11 12.1 0.1 1.7 1 0 0 1 1 1 0 Diacylglycerol kinase catalytic domain DEAD PF00270.29 ELR19790.1 - 0.065 13.0 0.0 0.11 12.3 0.0 1.2 1 0 0 1 1 1 0 DEAD/DEAH box helicase Ezh2_MCSS PF18600.1 ELR19790.1 - 0.21 11.2 0.8 3.7 7.2 0.1 2.4 2 0 0 2 2 2 0 MCSS domain Ank_2 PF12796.7 ELR19791.1 - 2.5e-21 76.0 0.0 1.2e-10 41.8 0.0 2.2 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ELR19791.1 - 7.8e-16 58.2 4.8 3.8e-05 24.2 0.1 4.3 2 2 3 5 5 5 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 ELR19791.1 - 2.2e-13 49.1 0.8 0.016 15.7 0.0 5.7 6 0 0 6 6 6 3 Ankyrin repeat Ank PF00023.30 ELR19791.1 - 1.2e-10 41.3 8.3 0.47 11.0 0.1 5.7 3 2 3 6 6 6 4 Ankyrin repeat Ank_5 PF13857.6 ELR19791.1 - 4.2e-08 33.3 4.5 0.57 10.6 0.0 4.8 2 2 3 5 5 5 3 Ankyrin repeats (many copies) DUF4604 PF15377.6 ELR19791.1 - 0.033 14.6 11.2 0.044 14.2 11.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4604) UPF0239 PF06783.11 ELR19791.1 - 2.2 8.5 8.1 3.2 8.0 7.3 1.7 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0239) F-box-like PF12937.7 ELR19792.1 - 5.4e-07 29.4 0.5 5.4e-07 29.4 0.5 1.8 2 0 0 2 2 2 1 F-box-like Ank_2 PF12796.7 ELR19792.1 - 0.00013 22.5 0.0 0.00032 21.2 0.0 1.8 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 ELR19792.1 - 0.00022 21.5 1.5 0.016 15.5 0.0 3.0 2 1 1 3 3 3 1 Ankyrin repeats (many copies) Ank_4 PF13637.6 ELR19792.1 - 0.0029 18.1 0.0 0.0093 16.5 0.0 1.8 1 1 1 2 2 2 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 ELR19792.1 - 0.021 15.3 0.0 12 6.8 0.0 2.8 2 0 0 2 2 2 0 Ankyrin repeat Ank PF00023.30 ELR19792.1 - 0.076 13.5 0.1 24 5.6 0.0 2.7 2 0 0 2 2 2 0 Ankyrin repeat HPP PF04982.13 ELR19793.1 - 0.011 15.9 0.1 0.011 15.9 0.1 2.6 2 1 0 3 3 3 0 HPP family ArAE_1 PF06081.11 ELR19793.1 - 0.033 14.3 3.8 0.039 14.1 1.2 2.1 2 0 0 2 2 2 0 Aromatic acid exporter family member 1 Phage-A118_gp45 PF10653.9 ELR19793.1 - 0.21 11.6 0.1 1.2 9.2 0.0 2.1 2 0 0 2 2 2 0 Protein gp45 of Bacteriophage A118 DUF389 PF04087.14 ELR19793.1 - 0.42 10.6 4.8 0.66 10.0 1.8 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF389) SMC_N PF02463.19 ELR19794.1 - 1.6e-21 76.8 0.0 3.5e-21 75.6 0.0 1.7 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_15 PF13175.6 ELR19794.1 - 1.4e-12 48.0 0.4 1.1e-07 31.9 0.0 3.1 3 1 0 3 3 3 1 AAA ATPase domain AAA_23 PF13476.6 ELR19794.1 - 3.2e-09 37.6 34.1 3.2e-09 37.6 34.1 5.8 3 2 0 3 3 3 1 AAA domain AAA_21 PF13304.6 ELR19794.1 - 9.7e-05 22.3 2.0 0.11 12.3 0.1 3.1 3 0 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 ELR19794.1 - 0.00016 21.3 0.0 0.00042 20.0 0.0 1.7 2 0 0 2 2 2 1 P-loop containing region of AAA domain Dopey_N PF04118.14 ELR19794.1 - 0.029 13.5 7.1 0.11 11.6 3.5 2.5 2 0 0 2 2 2 0 Dopey, N-terminal PatG_C PF18065.1 ELR19794.1 - 0.16 11.9 0.0 0.16 11.9 0.0 3.0 4 0 0 4 4 4 0 PatG C-terminal AAA_25 PF13481.6 ELR19794.1 - 0.18 11.4 3.1 0.35 10.4 0.0 2.9 2 1 0 2 2 2 0 AAA domain ABC_tran PF00005.27 ELR19794.1 - 0.18 12.3 0.0 0.18 12.3 0.0 4.4 3 2 0 3 3 3 0 ABC transporter MMPL PF03176.15 ELR19794.1 - 6.2 5.7 4.5 1.3 7.9 0.8 1.7 2 0 0 2 2 2 0 MMPL family RNase_P_Rpp14 PF01900.19 ELR19795.1 - 6.8e-30 103.4 0.1 7.9e-30 103.1 0.1 1.0 1 0 0 1 1 1 1 Rpp14/Pop5 family GAPT PF11770.8 ELR19796.1 - 0.091 12.6 0.0 0.16 11.8 0.0 1.4 1 0 0 1 1 1 0 GRB2-binding adapter (GAPT) OppC_N PF12911.7 ELR19796.1 - 0.55 10.2 3.3 0.7 9.9 0.0 2.1 2 0 0 2 2 2 0 N-terminal TM domain of oligopeptide transport permease C Rad51 PF08423.11 ELR19797.1 - 9.8e-132 437.9 0.1 1.2e-131 437.6 0.1 1.1 1 0 0 1 1 1 1 Rad51 AAA_25 PF13481.6 ELR19797.1 - 4.7e-12 45.9 0.0 7.2e-12 45.3 0.0 1.2 1 0 0 1 1 1 1 AAA domain RecA PF00154.21 ELR19797.1 - 1.6e-10 41.0 0.1 2.2e-10 40.5 0.1 1.1 1 0 0 1 1 1 1 recA bacterial DNA recombination protein ATPase PF06745.13 ELR19797.1 - 8.1e-07 28.6 0.3 2.3e-06 27.2 0.3 1.8 1 1 0 1 1 1 1 KaiC HHH_5 PF14520.6 ELR19797.1 - 7.7e-06 26.4 1.1 2e-05 25.1 0.3 2.0 2 0 0 2 2 2 1 Helix-hairpin-helix domain DnaB_C PF03796.15 ELR19797.1 - 0.0038 16.6 0.0 0.11 11.9 0.0 2.1 2 0 0 2 2 2 1 DnaB-like helicase C terminal domain AAA_24 PF13479.6 ELR19797.1 - 0.015 15.0 0.0 0.029 14.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain ssDNA_TraI_N PF18272.1 ELR19797.1 - 0.03 14.3 0.2 0.1 12.6 0.2 1.9 1 0 0 1 1 1 0 single-stranded DNA binding TraI N-terminal subdomain AAA_22 PF13401.6 ELR19797.1 - 0.033 14.5 0.1 0.08 13.2 0.1 1.6 1 1 0 1 1 1 0 AAA domain AAA_28 PF13521.6 ELR19797.1 - 0.15 12.3 0.5 0.34 11.2 0.1 1.8 2 0 0 2 2 2 0 AAA domain DEAD PF00270.29 ELR19798.1 - 5.9e-39 133.6 0.0 1.4e-38 132.5 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ELR19798.1 - 5e-24 84.8 0.0 1.3e-23 83.5 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain UTP25 PF06862.12 ELR19798.1 - 0.0033 16.3 0.0 0.007 15.2 0.0 1.5 2 0 0 2 2 2 1 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 zf-CCHC PF00098.23 ELR19798.1 - 0.0082 16.2 2.0 0.017 15.2 2.0 1.6 1 0 0 1 1 1 1 Zinc knuckle Helicase_C_2 PF13307.6 ELR19798.1 - 0.023 14.9 0.0 0.049 13.8 0.0 1.5 1 0 0 1 1 1 0 Helicase C-terminal domain SecA_DEAD PF07517.14 ELR19798.1 - 0.026 13.8 0.0 0.058 12.7 0.0 1.6 1 0 0 1 1 1 0 SecA DEAD-like domain DUF228 PF02989.14 ELR19798.1 - 0.075 12.8 0.0 0.17 11.7 0.0 1.5 1 0 0 1 1 1 0 Lyme disease proteins of unknown function zf-CCHC_4 PF14392.6 ELR19798.1 - 0.17 11.6 0.4 0.46 10.2 0.4 1.7 1 0 0 1 1 1 0 Zinc knuckle CT_C_D PF02682.16 ELR19798.1 - 0.18 11.5 0.0 0.31 10.7 0.0 1.3 1 0 0 1 1 1 0 Carboxyltransferase domain, subdomain C and D zf-C2H2_10 PF16588.5 ELR19798.1 - 0.27 11.0 1.6 0.54 10.0 1.6 1.4 1 0 0 1 1 1 0 C2H2 zinc-finger DnaJ-X PF14308.6 ELR19799.1 - 2.1e-23 82.9 4.6 2e-22 79.7 4.6 2.0 1 1 0 1 1 1 1 X-domain of DnaJ-containing MCPVI PF02993.14 ELR19799.1 - 0.0035 17.2 0.2 0.0054 16.6 0.2 1.2 1 0 0 1 1 1 1 Minor capsid protein VI HR1 PF02185.16 ELR19799.1 - 7.3 6.8 9.8 1.3 9.2 0.6 3.2 3 1 1 4 4 4 0 Hr1 repeat cNMP_binding PF00027.29 ELR19800.1 - 1.3e-08 34.8 0.0 2.7e-08 33.7 0.0 1.5 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain PPR_2 PF13041.6 ELR19800.1 - 1.4e-05 25.2 0.1 3.9e-05 23.8 0.0 1.7 2 0 0 2 2 2 1 PPR repeat family ECSIT PF06239.11 ELR19800.1 - 0.0034 16.6 0.0 0.42 9.7 0.0 2.2 2 0 0 2 2 2 2 Evolutionarily conserved signalling intermediate in Toll pathway PPR_3 PF13812.6 ELR19800.1 - 0.0048 16.9 0.0 0.0099 15.9 0.0 1.5 1 0 0 1 1 1 1 Pentatricopeptide repeat domain RRF_GI PF12614.8 ELR19800.1 - 0.084 13.0 0.0 0.2 11.8 0.0 1.6 1 0 0 1 1 1 0 Ribosome recycling factor cNMP_binding PF00027.29 ELR19801.1 - 2.2e-11 43.6 0.0 2.8e-11 43.3 0.0 1.2 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain Tmemb_14 PF03647.13 ELR19804.1 - 1.6e-19 70.4 9.9 2.1e-19 70.0 9.9 1.1 1 0 0 1 1 1 1 Transmembrane proteins 14C Aim19 PF10315.9 ELR19804.1 - 0.0016 18.7 3.3 0.002 18.4 3.3 1.2 1 0 0 1 1 1 1 Altered inheritance of mitochondria protein 19 DUF441 PF04284.13 ELR19804.1 - 0.015 15.3 0.3 0.028 14.4 0.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF441) NAD_Gly3P_dh_N PF01210.23 ELR19805.1 - 4.8e-26 91.6 0.0 6.6e-26 91.2 0.0 1.3 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus NAD_Gly3P_dh_C PF07479.14 ELR19805.1 - 5.9e-15 55.8 0.0 1.4e-14 54.5 0.0 1.5 2 0 0 2 2 2 1 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus ApbA PF02558.16 ELR19805.1 - 1.1e-08 34.8 0.0 1.5e-08 34.4 0.0 1.3 1 1 0 1 1 1 1 Ketopantoate reductase PanE/ApbA F420_oxidored PF03807.17 ELR19805.1 - 3.8e-06 27.4 0.0 1.1e-05 26.0 0.0 1.8 2 0 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent NAD_binding_2 PF03446.15 ELR19805.1 - 0.0018 18.4 0.0 0.0036 17.5 0.0 1.5 1 1 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase Sacchrp_dh_NADP PF03435.18 ELR19805.1 - 0.0023 18.2 0.0 0.0037 17.5 0.0 1.4 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain TrkA_N PF02254.18 ELR19805.1 - 0.0025 18.1 0.0 0.007 16.6 0.0 1.9 1 1 0 2 2 2 1 TrkA-N domain 3HCDH_N PF02737.18 ELR19805.1 - 0.0035 17.3 0.0 0.014 15.3 0.0 1.9 1 1 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain DAO PF01266.24 ELR19805.1 - 0.0082 15.8 0.0 0.0083 15.7 0.0 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 ELR19805.1 - 0.014 14.6 0.0 0.022 14.0 0.0 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Shikimate_DH PF01488.20 ELR19805.1 - 0.018 15.1 0.0 0.036 14.1 0.0 1.5 1 1 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Pyr_redox PF00070.27 ELR19805.1 - 0.02 15.4 0.0 0.041 14.5 0.0 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_7 PF13241.6 ELR19805.1 - 0.029 14.8 0.0 0.044 14.2 0.0 1.3 1 0 0 1 1 1 0 Putative NAD(P)-binding Cas_Cas1 PF01867.16 ELR19805.1 - 0.049 12.8 0.0 0.06 12.5 0.0 1.2 1 0 0 1 1 1 0 CRISPR associated protein Cas1 adh_short PF00106.25 ELR19805.1 - 0.051 13.0 0.0 0.078 12.4 0.0 1.3 1 0 0 1 1 1 0 short chain dehydrogenase XdhC_C PF13478.6 ELR19805.1 - 0.055 14.0 0.1 0.089 13.3 0.1 1.6 1 1 0 1 1 1 0 XdhC Rossmann domain NAD_binding_8 PF13450.6 ELR19805.1 - 0.092 13.0 0.0 0.18 12.1 0.0 1.5 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain E3_binding PF02817.17 ELR19805.1 - 0.1 13.0 0.0 0.24 11.8 0.0 1.7 1 0 0 1 1 1 0 e3 binding domain AlaDh_PNT_C PF01262.21 ELR19805.1 - 0.12 11.7 0.0 0.17 11.1 0.0 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain NAD_binding_10 PF13460.6 ELR19805.1 - 0.13 12.1 1.3 1.2 8.9 0.3 2.6 1 1 2 3 3 3 0 NAD(P)H-binding Pyr_redox_3 PF13738.6 ELR19805.1 - 0.15 11.3 0.0 0.2 10.9 0.0 1.1 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase AMP-binding PF00501.28 ELR19808.1 - 9.2e-28 97.0 0.0 1.1e-27 96.7 0.0 1.0 1 0 0 1 1 1 1 AMP-binding enzyme Methyltransf_16 PF10294.9 ELR19810.1 - 2.2e-23 82.9 0.1 3.5e-23 82.2 0.1 1.3 1 0 0 1 1 1 1 Lysine methyltransferase Methyltransf_23 PF13489.6 ELR19810.1 - 0.0005 19.9 0.0 0.00087 19.2 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain GidB PF02527.15 ELR19810.1 - 0.047 13.0 0.0 0.1 11.9 0.0 1.5 1 0 0 1 1 1 0 rRNA small subunit methyltransferase G MTS PF05175.14 ELR19810.1 - 0.063 12.8 0.0 0.65 9.5 0.0 2.0 2 0 0 2 2 2 0 Methyltransferase small domain HLH PF00010.26 ELR19811.1 - 4.3e-13 49.0 0.8 8.4e-13 48.1 0.8 1.5 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain PhoLip_ATPase_C PF16212.5 ELR19812.1 - 1.7e-19 70.6 12.6 2.6e-19 69.9 12.6 1.3 1 0 0 1 1 1 1 Phospholipid-translocating P-type ATPase C-terminal Hydrolase PF00702.26 ELR19812.1 - 0.0004 20.7 0.0 0.41 10.9 0.0 2.3 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 ELR19812.1 - 0.00047 20.2 0.0 0.001 19.1 0.0 1.6 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 ELR19812.1 - 0.0012 18.7 1.0 0.022 14.5 0.2 2.3 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase DUF3920 PF13058.6 ELR19812.1 - 0.077 13.2 0.5 0.16 12.2 0.5 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3920) DUF572 PF04502.13 ELR19812.1 - 0.12 12.0 9.3 0.17 11.5 9.3 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) E1-E2_ATPase PF00122.20 ELR19813.1 - 2.7e-09 36.8 0.0 5.2e-09 35.9 0.0 1.5 1 0 0 1 1 1 1 E1-E2 ATPase PhoLip_ATPase_N PF16209.5 ELR19813.1 - 0.0036 17.0 0.1 0.0036 17.0 0.1 2.4 3 0 0 3 3 3 1 Phospholipid-translocating ATPase N-terminal Yip1 PF04893.17 ELR19813.1 - 0.23 11.1 5.1 3.7 7.2 1.0 2.1 2 0 0 2 2 2 0 Yip1 domain Thr_synth_N PF14821.6 ELR19815.1 - 3.4e-21 75.3 0.0 9.8e-21 73.8 0.0 1.9 2 0 0 2 2 2 1 Threonine synthase N terminus PALP PF00291.25 ELR19815.1 - 4.9e-13 49.2 0.0 1.2e-12 47.9 0.0 1.5 1 1 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme LpxK PF02606.14 ELR19815.1 - 0.13 11.4 0.1 0.2 10.8 0.1 1.2 1 0 0 1 1 1 0 Tetraacyldisaccharide-1-P 4'-kinase PK_C PF02887.16 ELR19815.1 - 0.16 12.2 0.0 0.41 10.9 0.0 1.6 1 0 0 1 1 1 0 Pyruvate kinase, alpha/beta domain Metallophos PF00149.28 ELR19816.1 - 1.3e-13 51.9 0.1 2.2e-13 51.2 0.1 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 ELR19816.1 - 1e-08 35.6 0.0 2.2e-08 34.5 0.0 1.6 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Epimerase_2 PF02350.19 ELR19816.1 - 0.069 12.0 0.0 0.096 11.5 0.0 1.1 1 0 0 1 1 1 0 UDP-N-acetylglucosamine 2-epimerase HTH_Tnp_Tc5 PF03221.16 ELR19816.1 - 0.11 12.5 0.1 0.11 12.5 0.1 1.9 2 1 0 2 2 2 0 Tc5 transposase DNA-binding domain Pkinase_Tyr PF07714.17 ELR19817.1 - 6.7e-59 199.3 0.0 9.8e-59 198.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ELR19817.1 - 4.4e-36 124.6 0.0 6.8e-36 124.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain SAM_1 PF00536.30 ELR19817.1 - 8.7e-10 38.9 0.0 1.8e-09 37.9 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 ELR19817.1 - 6.8e-07 29.3 0.1 1.5e-06 28.2 0.1 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) F-box-like PF12937.7 ELR19817.1 - 0.00023 21.0 0.3 0.00023 21.0 0.3 1.9 2 0 0 2 2 2 1 F-box-like MORN PF02493.20 ELR19817.1 - 0.0052 16.6 0.4 0.014 15.3 0.4 1.8 1 0 0 1 1 1 1 MORN repeat Kinase-like PF14531.6 ELR19817.1 - 0.013 14.9 0.0 0.022 14.1 0.0 1.3 1 0 0 1 1 1 0 Kinase-like Kdo PF06293.14 ELR19817.1 - 0.068 12.5 0.0 0.11 11.8 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family F-box PF00646.33 ELR19817.1 - 0.084 12.8 0.1 0.21 11.5 0.1 1.6 1 0 0 1 1 1 0 F-box domain BAR PF03114.18 ELR19818.1 - 1.3e-27 97.0 0.5 1.8e-27 96.6 0.5 1.2 1 0 0 1 1 1 1 BAR domain SH3_9 PF14604.6 ELR19818.1 - 1.2e-14 53.9 0.0 1.9e-14 53.3 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 ELR19818.1 - 2.4e-14 52.6 0.0 3.9e-14 52.0 0.0 1.4 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 ELR19818.1 - 2.3e-08 33.6 0.0 4.4e-08 32.7 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain Arfaptin PF06456.13 ELR19818.1 - 7.2e-05 22.5 0.7 0.14 11.7 0.1 2.2 2 0 0 2 2 2 2 Arfaptin-like domain DUF166 PF02593.14 ELR19818.1 - 0.14 11.7 0.1 0.22 11.0 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function Nucleoporin_FG PF13634.6 ELR19818.1 - 1.2 10.0 13.4 2 9.3 12.7 1.7 1 1 0 1 1 1 0 Nucleoporin FG repeat region DUF4962 PF16332.5 ELR19818.1 - 1.3 7.4 3.7 0.58 8.6 0.5 1.9 2 1 1 3 3 3 0 Domain of unknown function (DUF4962) Homeodomain PF00046.29 ELR19819.1 - 2.3e-18 65.8 1.4 2.3e-18 65.8 1.4 2.3 2 0 0 2 2 2 1 Homeodomain Homeobox_KN PF05920.11 ELR19819.1 - 0.0017 18.2 0.3 0.0065 16.4 0.3 2.0 1 0 0 1 1 1 1 Homeobox KN domain CLTH PF10607.9 ELR19820.1 - 6.5e-22 78.0 0.0 1.1e-21 77.3 0.0 1.4 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain zf-RING_UBOX PF13445.6 ELR19820.1 - 0.00037 20.5 5.0 0.00078 19.4 5.0 1.6 1 0 0 1 1 1 1 RING-type zinc-finger LisH PF08513.11 ELR19820.1 - 0.00082 19.3 0.1 0.0016 18.3 0.1 1.5 1 0 0 1 1 1 1 LisH DUF1382 PF07131.11 ELR19820.1 - 0.043 13.8 0.2 0.1 12.6 0.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1382) Urocanase PF01175.18 ELR19820.1 - 0.05 13.3 0.2 0.083 12.5 0.2 1.3 1 0 0 1 1 1 0 Urocanase Rossmann-like domain Mu-like_Pro PF10123.9 ELR19820.1 - 0.06 12.9 1.8 0.11 12.1 1.8 1.3 1 0 0 1 1 1 0 Mu-like prophage I protein zf-RING_5 PF14634.6 ELR19820.1 - 0.11 12.4 1.9 0.23 11.5 1.9 1.5 1 0 0 1 1 1 0 zinc-RING finger domain DUF5446 PF17522.2 ELR19820.1 - 0.12 12.6 0.3 0.39 10.9 0.3 1.8 1 0 0 1 1 1 0 Family of unknown function (DUF5446) TFIID_NTD2 PF04494.15 ELR19820.1 - 0.27 11.5 2.0 0.74 10.0 0.1 2.4 3 1 1 4 4 4 0 WD40 associated region in TFIID subunit, NTD2 domain zf-RING_2 PF13639.6 ELR19820.1 - 1.2 9.5 4.2 2.8 8.4 4.2 1.7 1 0 0 1 1 1 0 Ring finger domain SAM_1 PF00536.30 ELR19821.1 - 1.2e-06 28.8 0.1 2.4e-06 27.9 0.1 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 ELR19821.1 - 0.18 11.9 0.1 0.34 11.0 0.1 1.4 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) Acyltransferase PF01553.21 ELR19822.1 - 1.1e-19 70.4 0.0 1.6e-19 69.8 0.0 1.3 1 0 0 1 1 1 1 Acyltransferase Acyltransf_C PF16076.5 ELR19822.1 - 3.4e-17 62.3 0.5 6.7e-17 61.4 0.5 1.5 1 0 0 1 1 1 1 Acyltransferase C-terminus PBP PF01161.20 ELR19823.1 - 1.2e-13 51.5 0.0 1.9e-13 50.9 0.0 1.3 1 1 0 1 1 1 1 Phosphatidylethanolamine-binding protein Neurochondrin PF05536.11 ELR19824.1 - 6.9e-13 47.8 0.0 1.2e-12 47.1 0.0 1.3 1 0 0 1 1 1 1 Neurochondrin JMY PF15871.5 ELR19824.1 - 0.17 11.2 2.7 0.28 10.4 2.7 1.2 1 0 0 1 1 1 0 Junction-mediating and -regulatory protein DGF-1_C PF11040.8 ELR19824.1 - 2 8.4 7.4 0.63 10.1 2.4 2.7 2 1 1 3 3 3 0 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus Spc7 PF08317.11 ELR19824.1 - 2.3 7.0 6.9 3.9 6.3 6.9 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein Neurochondrin PF05536.11 ELR19825.1 - 2.7e-26 92.1 0.0 3.4e-26 91.8 0.0 1.0 1 0 0 1 1 1 1 Neurochondrin DUF3453 PF11935.8 ELR19825.1 - 0.12 12.0 0.0 15 5.1 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF3453) XPG_I_2 PF12813.7 ELR19826.1 - 2.2e-09 37.2 0.0 4e-09 36.3 0.0 1.4 1 0 0 1 1 1 1 XPG domain containing XPG_I PF00867.18 ELR19826.1 - 0.061 13.7 0.0 0.21 12.0 0.0 2.0 1 0 0 1 1 1 0 XPG I-region Neurochondrin PF05536.11 ELR19826.1 - 0.14 10.5 0.0 0.23 9.8 0.0 1.2 1 0 0 1 1 1 0 Neurochondrin XPG_N PF00752.17 ELR19826.1 - 0.14 12.6 0.0 5.9 7.4 0.0 3.0 2 1 0 2 2 2 0 XPG N-terminal domain SelK_SelG PF10961.8 ELR19826.1 - 5.7 7.6 7.9 42 4.8 1.2 3.9 3 0 0 3 3 3 0 Selenoprotein SelK_SelG MspA PF09203.11 ELR19827.1 - 0.086 12.7 2.0 0.21 11.4 0.0 2.4 3 0 0 3 3 3 0 MspA EF-hand_1 PF00036.32 ELR19828.1 - 3.8e-25 85.5 5.7 4.7e-07 28.9 0.0 4.2 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.6 ELR19828.1 - 7e-24 81.7 4.4 2.3e-07 30.2 0.4 4.5 4 0 0 4 4 4 3 EF-hand domain EF-hand_5 PF13202.6 ELR19828.1 - 8.6e-20 69.3 6.8 1.5e-06 27.4 0.0 4.4 4 0 0 4 4 4 3 EF hand EF-hand_7 PF13499.6 ELR19828.1 - 1.1e-17 64.3 7.1 1.5e-12 47.8 0.7 3.6 2 2 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 ELR19828.1 - 3.7e-15 55.5 8.2 3.4e-06 26.8 0.2 4.1 3 1 1 4 4 4 3 EF-hand domain pair EF-hand_4 PF12763.7 ELR19828.1 - 2.3e-08 33.9 0.4 0.03 14.3 0.0 3.2 2 1 1 3 3 3 2 Cytoskeletal-regulatory complex EF hand ZZ PF00569.17 ELR19828.1 - 4.5e-08 32.8 5.2 7.4e-08 32.1 5.2 1.3 1 0 0 1 1 1 1 Zinc finger, ZZ type SPARC_Ca_bdg PF10591.9 ELR19828.1 - 1.5e-05 25.2 0.8 0.16 12.3 0.0 3.3 3 1 0 3 3 3 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_3 PF09069.11 ELR19828.1 - 0.0027 18.1 0.1 0.054 13.9 0.0 2.6 2 0 0 2 2 2 1 EF-hand Dockerin_1 PF00404.18 ELR19828.1 - 0.004 17.3 0.0 0.36 11.1 0.0 2.8 3 0 0 3 3 3 1 Dockerin type I domain C1_2 PF03107.16 ELR19828.1 - 0.012 15.9 3.6 0.02 15.2 3.6 1.4 1 0 0 1 1 1 0 C1 domain EF-hand_9 PF14658.6 ELR19828.1 - 0.066 13.5 0.0 1.5 9.2 0.0 2.8 3 0 0 3 3 3 0 EF-hand domain EF-hand_2 PF09068.11 ELR19828.1 - 0.1 12.8 0.1 4.9 7.3 0.0 2.7 2 1 1 3 3 3 0 EF hand VCBS PF13517.6 ELR19828.1 - 0.42 11.2 2.9 50 4.6 0.0 2.9 2 1 0 2 2 2 0 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella Caleosin PF05042.13 ELR19828.1 - 0.53 10.2 3.9 7 6.6 0.1 3.4 3 1 1 4 4 4 0 Caleosin related protein FG-GAP PF01839.23 ELR19828.1 - 2.1 8.5 6.0 9.4 6.5 0.2 2.6 2 0 0 2 2 2 0 FG-GAP repeat NADH_B2 PF14813.6 ELR19829.1 - 2.1e-08 33.8 1.0 2.4e-08 33.6 1.0 1.1 1 0 0 1 1 1 1 NADH dehydrogenase 1 beta subcomplex subunit 2 DUF92 PF01940.16 ELR19830.1 - 5.3e-76 255.1 5.9 6.2e-76 254.9 5.9 1.0 1 0 0 1 1 1 1 Integral membrane protein DUF92 zf-CCCH PF00642.24 ELR19831.1 - 5.4e-21 74.0 15.0 2.9e-11 43.0 3.1 2.5 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 ELR19831.1 - 5.7e-13 48.5 13.0 2.4e-06 27.4 2.6 2.4 2 0 0 2 2 2 2 Zinc finger domain zf-CCCH_4 PF18044.1 ELR19831.1 - 6.2e-10 38.6 9.9 1.2e-06 28.1 0.9 2.4 2 0 0 2 2 2 2 CCCH-type zinc finger Torus PF16131.5 ELR19831.1 - 0.00027 21.6 10.2 0.0051 17.5 0.1 3.2 3 0 0 3 3 3 2 Torus domain zf-CCCH_2 PF14608.6 ELR19831.1 - 0.0003 21.1 8.4 0.035 14.6 0.3 2.6 2 0 0 2 2 2 2 RNA-binding, Nab2-type zinc finger Ribosomal_60s PF00428.19 ELR19831.1 - 0.68 10.6 7.7 0.12 13.0 3.9 1.8 2 0 0 2 2 2 0 60s Acidic ribosomal protein HECT PF00632.25 ELR19832.1 - 9.8e-86 288.0 0.0 1.6e-85 287.3 0.0 1.3 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) AZUL PF16558.5 ELR19832.1 - 1.3e-15 57.3 0.8 3.2e-15 56.1 0.8 1.7 1 0 0 1 1 1 1 Amino-terminal Zinc-binding domain of ubiquitin ligase E3A Nucleo_P87 PF07267.11 ELR19832.1 - 0.87 8.4 13.2 2 7.2 13.2 1.6 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 RR_TM4-6 PF06459.12 ELR19832.1 - 1.9 8.3 21.6 3 7.6 21.6 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Macro PF01661.21 ELR19833.1 - 3.2e-25 88.5 0.0 7.8e-25 87.2 0.0 1.6 1 1 0 1 1 1 1 Macro domain Actin PF00022.19 ELR19834.1 - 7.8e-59 199.3 0.0 1.3e-57 195.3 0.0 2.4 1 1 0 1 1 1 1 Actin Pyrophosphatase PF00719.19 ELR19836.1 - 0.027 14.3 0.7 0.074 12.9 0.7 1.7 1 0 0 1 1 1 0 Inorganic pyrophosphatase CBS PF00571.28 ELR19837.1 - 2e-14 53.8 1.8 0.0032 17.9 0.0 5.9 6 0 0 6 6 6 4 CBS domain DEP PF00610.21 ELR19838.1 - 3.1e-47 158.5 0.5 7.4e-23 80.4 0.1 2.2 2 0 0 2 2 2 2 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) GSHPx PF00255.19 ELR19838.1 - 1.8e-24 85.4 0.4 6.5e-22 77.1 0.5 2.3 1 1 1 2 2 2 2 Glutathione peroxidase APH PF01636.23 ELR19839.1 - 6.1e-20 72.2 0.9 7.2e-20 71.9 0.9 1.1 1 0 0 1 1 1 1 Phosphotransferase enzyme family EcKinase PF02958.20 ELR19839.1 - 0.00089 18.7 0.0 0.0012 18.2 0.0 1.1 1 0 0 1 1 1 1 Ecdysteroid kinase T6SS_HCP PF05638.12 ELR19840.1 - 7.2e-15 55.5 0.2 8.6e-10 39.1 0.1 2.2 1 1 1 2 2 2 2 Type VI secretion system effector, Hcp Eapp_C PF10238.9 ELR19840.1 - 0.095 12.8 0.3 0.13 12.3 0.3 1.2 1 0 0 1 1 1 0 E2F-associated phosphoprotein SRPRB PF09439.10 ELR19841.1 - 1e-30 106.6 0.0 1.3e-30 106.2 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Arf PF00025.21 ELR19841.1 - 5.6e-11 42.2 0.0 7.6e-11 41.8 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 ELR19841.1 - 3.8e-05 23.3 0.0 5.4e-05 22.8 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 ELR19841.1 - 0.0077 16.3 0.0 0.013 15.5 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase NRD1_2 PF01995.16 ELR19841.1 - 0.13 11.5 0.0 0.2 10.9 0.0 1.3 1 0 0 1 1 1 0 NrpR regulatory domains NRD1 and 2 Lactamase_B PF00753.27 ELR19842.1 - 1.3e-05 25.3 3.2 9.4e-05 22.5 3.2 2.1 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily LRR_8 PF13855.6 ELR19843.1 - 1.9e-34 117.2 56.5 1.7e-06 27.7 1.3 10.5 7 4 4 11 11 11 11 Leucine rich repeat LRR_4 PF12799.7 ELR19843.1 - 2.3e-33 113.6 55.7 7.4e-06 26.2 2.6 12.5 8 4 5 13 13 13 12 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 ELR19843.1 - 2.6e-21 75.9 25.3 3e-05 23.6 0.1 8.0 7 2 0 7 7 7 6 Leucine-rich repeat LRR_6 PF13516.6 ELR19843.1 - 1.8e-14 52.5 43.1 5.4e-05 22.9 0.1 13.7 15 0 0 15 15 15 6 Leucine Rich repeat LRR_1 PF00560.33 ELR19843.1 - 0.0014 18.9 40.9 11 7.1 0.1 13.8 11 2 2 13 13 13 2 Leucine Rich Repeat PAP1 PF08601.10 ELR19844.1 - 0.22 11.2 3.4 0.29 10.8 3.4 1.3 1 0 0 1 1 1 0 Transcription factor PAP1 F-box PF00646.33 ELR19845.1 - 0.00046 20.0 0.0 0.00093 19.0 0.0 1.5 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 ELR19845.1 - 0.026 14.4 0.0 0.065 13.1 0.0 1.7 1 0 0 1 1 1 0 F-box-like Filamin PF00630.19 ELR19847.1 - 1e-102 337.9 11.9 1.6e-22 80.3 0.1 5.2 5 0 0 5 5 5 5 Filamin/ABP280 repeat CH PF00307.31 ELR19847.1 - 2e-43 147.0 0.1 3.8e-23 81.8 0.0 2.3 2 0 0 2 2 2 2 Calponin homology (CH) domain Invasin_D3 PF09134.10 ELR19847.1 - 1e-26 93.1 11.9 3.1e-06 27.4 0.2 5.6 6 0 0 6 6 6 4 Invasin, domain 3 YtkA PF13115.6 ELR19847.1 - 9.9e-13 48.5 9.3 0.015 15.9 0.2 5.4 5 0 0 5 5 5 3 YtkA-like Y_Y_Y PF07495.13 ELR19847.1 - 1.9e-07 30.9 1.0 0.13 12.2 0.0 4.5 4 0 0 4 4 4 2 Y_Y_Y domain DUF5060 PF16586.5 ELR19847.1 - 2.1e-06 28.0 0.8 0.21 12.0 0.0 4.3 4 0 0 4 4 4 2 Domain of unknown function (DUF5060) Big_1 PF02369.16 ELR19847.1 - 6e-06 26.2 11.7 0.02 14.9 0.1 5.1 5 0 0 5 5 5 2 Bacterial Ig-like domain (group 1) Big_6 PF17936.1 ELR19847.1 - 1.4e-05 25.2 9.5 0.16 12.3 0.0 5.2 5 0 0 5 5 5 2 Bacterial Ig domain DUF756 PF05506.12 ELR19847.1 - 0.002 19.0 2.3 6.2 7.8 0.1 5.4 4 2 2 6 6 6 1 Domain of unknown function (DUF756) PKD PF00801.20 ELR19847.1 - 0.007 16.2 3.3 0.83 9.5 0.7 3.8 4 0 0 4 4 4 1 PKD domain CAMSAP_CH PF11971.8 ELR19847.1 - 0.014 15.2 0.0 4.1 7.3 0.0 2.5 2 0 0 2 2 2 0 CAMSAP CH domain CopC PF04234.12 ELR19847.1 - 0.016 16.3 5.2 19 6.4 0.1 5.1 4 1 1 5 5 5 0 CopC domain Big_3_5 PF16640.5 ELR19847.1 - 0.021 15.0 8.6 3.9 7.7 0.2 4.3 4 0 0 4 4 4 0 Bacterial Ig-like domain (group 3) Cadherin_5 PF17892.1 ELR19847.1 - 0.027 14.5 17.9 0.12 12.3 0.6 5.3 5 0 0 5 5 5 0 Cadherin-like domain FixH PF05751.11 ELR19847.1 - 0.047 13.7 0.2 18 5.3 0.0 4.2 5 0 0 5 5 5 0 FixH HepII_C PF18675.1 ELR19847.1 - 0.31 11.1 3.6 15 5.8 0.0 4.3 5 0 0 5 5 5 0 Heparinase II C-terminal domain Glyco_hydro2_C5 PF18565.1 ELR19847.1 - 1.3 8.9 8.2 4.9 7.0 0.1 3.5 4 0 0 4 4 4 0 Glycoside hydrolase family 2 C-terminal domain 5 CH PF00307.31 ELR19848.1 - 7.2e-25 87.3 0.0 8.1e-25 87.1 0.0 1.0 1 0 0 1 1 1 1 Calponin homology (CH) domain Ribosomal_L3 PF00297.22 ELR19848.1 - 0.19 10.6 0.1 0.24 10.4 0.1 1.1 1 0 0 1 1 1 0 Ribosomal protein L3 PH PF00169.29 ELR19849.1 - 1.4e-08 35.2 0.2 5.8e-08 33.2 0.1 2.0 2 0 0 2 2 2 1 PH domain PH_11 PF15413.6 ELR19849.1 - 0.022 15.2 0.1 0.062 13.7 0.1 1.8 1 0 0 1 1 1 0 Pleckstrin homology domain PH PF00169.29 ELR19850.1 - 3e-09 37.3 0.1 8.1e-09 35.9 0.0 1.8 2 0 0 2 2 2 1 PH domain PH_8 PF15409.6 ELR19850.1 - 0.04 14.2 0.3 0.2 12.0 0.3 2.1 1 1 0 1 1 1 0 Pleckstrin homology domain Methyltransf_16 PF10294.9 ELR19852.1 - 1.4e-11 44.4 0.2 1.9e-11 44.0 0.2 1.2 1 0 0 1 1 1 1 Lysine methyltransferase PrmA PF06325.13 ELR19852.1 - 0.02 14.3 0.4 0.02 14.3 0.4 1.6 2 0 0 2 2 2 0 Ribosomal protein L11 methyltransferase (PrmA) ApoL PF05461.11 ELR19852.1 - 0.18 11.1 1.7 0.24 10.7 1.7 1.2 1 0 0 1 1 1 0 Apolipoprotein L Aa_trans PF01490.18 ELR19853.1 - 1.7e-23 83.0 4.8 2e-23 82.8 4.8 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein GCV_T_C PF08669.11 ELR19855.1 - 0.031 14.2 0.0 0.068 13.1 0.0 1.6 1 0 0 1 1 1 0 Glycine cleavage T-protein C-terminal barrel domain PBP_like_2 PF12849.7 ELR19856.1 - 4.2e-26 92.3 9.6 3.2e-14 53.3 2.1 2.1 2 0 0 2 2 2 2 PBP superfamily domain Pkinase_Tyr PF07714.17 ELR19857.1 - 3.9e-15 55.8 0.1 9.7e-15 54.5 0.1 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ELR19857.1 - 2.9e-14 53.1 0.8 6.4e-14 51.9 0.8 1.7 1 1 0 1 1 1 1 Protein kinase domain Kinase-like PF14531.6 ELR19857.1 - 0.019 14.3 0.0 0.023 14.0 0.0 1.1 1 0 0 1 1 1 0 Kinase-like RNA_ligase PF09414.10 ELR19858.1 - 2.5e-11 44.2 0.0 3.2e-11 43.8 0.0 1.1 1 0 0 1 1 1 1 RNA ligase DUF3348 PF11828.8 ELR19859.1 - 0.011 15.5 0.6 0.011 15.5 0.6 2.2 3 0 0 3 3 3 0 Protein of unknown function (DUF3348) FliJ PF02050.16 ELR19859.1 - 0.011 16.0 5.8 0.12 12.6 1.0 2.4 2 0 0 2 2 2 0 Flagellar FliJ protein DUF4407 PF14362.6 ELR19859.1 - 0.14 11.5 6.9 0.26 10.6 6.9 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) OmpH PF03938.14 ELR19859.1 - 0.38 11.1 4.7 1.9 8.8 0.2 2.3 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) Golgin_A5 PF09787.9 ELR19859.1 - 0.57 9.6 11.7 0.21 11.0 1.4 2.2 2 0 0 2 2 2 0 Golgin subfamily A member 5 DUF4140 PF13600.6 ELR19859.1 - 1.3 9.5 7.4 0.21 12.0 0.7 2.5 2 0 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) DUF883 PF05957.13 ELR19859.1 - 8.9 7.0 14.7 5 7.8 0.9 2.7 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF883) Inhibitor_I29 PF08246.12 ELR19860.1 - 3.1e-10 40.3 1.9 5.3e-10 39.6 1.8 1.4 1 1 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) EpsG PF14897.6 ELR19860.1 - 0.22 10.8 0.2 0.22 10.8 0.2 1.4 2 0 0 2 2 2 0 EpsG family HATPase_c PF02518.26 ELR19861.1 - 5.1e-29 101.0 0.1 2e-28 99.1 0.0 1.9 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 ELR19861.1 - 1.3e-08 34.7 0.1 2.3e-08 33.9 0.1 1.4 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain HATPase_c_3 PF13589.6 ELR19861.1 - 0.0057 16.5 0.0 0.015 15.1 0.0 2.0 1 1 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Aldedh PF00171.22 ELR19862.1 - 4.9e-84 282.5 0.0 6e-84 282.2 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DHC_N1 PF08385.12 ELR19862.1 - 0.2 10.3 0.0 0.29 9.7 0.0 1.1 1 0 0 1 1 1 0 Dynein heavy chain, N-terminal region 1 DDT PF02791.17 ELR19863.1 - 0.00037 20.8 0.1 0.019 15.2 0.1 2.4 2 0 0 2 2 2 1 DDT domain BUD22 PF09073.10 ELR19863.1 - 0.4 10.0 64.8 0.18 11.1 47.6 2.3 2 0 0 2 2 2 0 BUD22 CDC27 PF09507.10 ELR19863.1 - 7.8 5.8 75.5 0.37 10.1 52.1 2.1 2 0 0 2 2 2 0 DNA polymerase subunit Cdc27 D123 PF07065.14 ELR19864.1 - 4.5e-100 334.8 8.0 1.4e-88 297.1 0.2 2.1 1 1 1 2 2 2 2 D123 DNA_pol_phi PF04931.13 ELR19864.1 - 0.93 7.5 14.2 1.4 6.9 14.2 1.2 1 0 0 1 1 1 0 DNA polymerase phi Cwf_Cwc_15 PF04889.12 ELR19864.1 - 5.2 6.7 16.6 1.6 8.4 11.9 2.1 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein Pox_Ag35 PF03286.14 ELR19864.1 - 6.1 6.6 11.7 9.8 5.9 8.4 2.2 2 0 0 2 2 2 0 Pox virus Ag35 surface protein MFS_1 PF07690.16 ELR19865.1 - 1e-26 93.7 46.5 8.6e-20 70.9 23.8 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily SPC12 PF06645.13 ELR19865.1 - 0.097 12.8 10.1 0.15 12.1 0.4 3.6 3 0 0 3 3 3 0 Microsomal signal peptidase 12 kDa subunit (SPC12) Fez1 PF06818.15 ELR19866.1 - 0.0003 21.3 5.4 0.0003 21.3 5.4 2.6 2 1 1 3 3 3 1 Fez1 DUF1640 PF07798.11 ELR19866.1 - 0.016 15.3 18.1 0.59 10.2 0.7 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1640) DUF4239 PF14023.6 ELR19866.1 - 0.067 12.9 8.5 0.58 9.8 0.0 2.7 1 1 2 3 3 3 0 Protein of unknown function (DUF4239) Herpes_BLRF2 PF05812.12 ELR19866.1 - 0.81 9.8 18.9 0.15 12.2 5.5 3.1 1 1 2 3 3 3 0 Herpesvirus BLRF2 protein Pepsin-I3 PF06394.13 ELR19866.1 - 1.5 9.1 12.1 1.4 9.2 0.1 3.4 2 1 1 3 3 3 0 Pepsin inhibitor-3-like repeated domain DUF3450 PF11932.8 ELR19866.1 - 3 7.1 26.8 0.044 13.1 11.4 3.1 1 1 2 3 3 3 0 Protein of unknown function (DUF3450) CENP-Q PF13094.6 ELR19866.1 - 3.7 7.7 22.2 2.2 8.5 2.3 2.8 1 1 1 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit DUF4618 PF15397.6 ELR19866.1 - 4 6.8 27.0 1.2 8.5 1.3 2.3 1 1 0 2 2 2 0 Domain of unknown function (DUF4618) Mto2_bdg PF12808.7 ELR19866.1 - 4.9 7.5 14.3 1.4 9.3 0.3 4.1 3 2 1 4 4 4 0 Micro-tubular organiser Mto1 C-term Mto2-binding region FUSC PF04632.12 ELR19866.1 - 5.4 5.4 5.4 9.3 4.6 5.4 1.5 1 1 0 1 1 1 0 Fusaric acid resistance protein family Tup_N PF08581.10 ELR19866.1 - 6 7.2 17.9 0.46 10.8 9.1 3.4 3 1 0 3 3 3 0 Tup N-terminal ABC_ATPase PF09818.9 ELR19867.1 - 3.1e-174 580.0 0.0 4.5e-174 579.5 0.0 1.2 1 0 0 1 1 1 1 Predicted ATPase of the ABC class AAA_23 PF13476.6 ELR19867.1 - 1.1e-05 26.0 0.2 0.001 19.6 0.1 2.2 2 0 0 2 2 2 2 AAA domain AAA_29 PF13555.6 ELR19867.1 - 0.0097 15.6 0.2 0.062 13.1 0.1 2.4 2 0 0 2 2 2 1 P-loop containing region of AAA domain GST_N PF02798.20 ELR19868.1 - 1.5e-15 57.2 0.0 5.2e-15 55.6 0.0 1.8 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 ELR19868.1 - 1.8e-14 53.8 0.0 2.6e-14 53.2 0.0 1.2 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 ELR19868.1 - 1.1e-09 38.3 0.0 1.8e-09 37.7 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 ELR19868.1 - 0.00045 20.2 0.1 0.0025 17.8 0.1 2.2 2 1 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_6 PF17171.4 ELR19868.1 - 0.046 13.5 0.2 0.1 12.4 0.2 1.7 1 1 0 1 1 1 0 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 ELR19868.1 - 0.048 14.1 0.0 0.14 12.6 0.0 1.7 1 1 0 1 1 1 0 Glutathione S-transferase, N-terminal domain Prok-E2_E PF14462.6 ELR19868.1 - 0.14 12.0 0.0 0.27 11.1 0.0 1.4 1 0 0 1 1 1 0 Prokaryotic E2 family E Aldo_ket_red PF00248.21 ELR19870.1 - 2.1e-58 197.8 0.0 7.5e-58 196.0 0.0 1.7 1 1 0 1 1 1 1 Aldo/keto reductase family RabGAP-TBC PF00566.18 ELR19871.1 - 4.5e-53 180.1 0.0 6.7e-53 179.5 0.0 1.2 1 0 0 1 1 1 1 Rab-GTPase-TBC domain BTB_2 PF02214.22 ELR19871.1 - 0.03 14.7 0.1 0.85 10.0 0.0 2.8 3 0 0 3 3 3 0 BTB/POZ domain PTEN_C2 PF10409.9 ELR19872.1 - 2.6e-15 56.4 0.1 7.9e-15 54.8 0.0 2.0 2 1 0 2 2 2 1 C2 domain of PTEN tumour-suppressor protein PTPlike_phytase PF14566.6 ELR19872.1 - 1.6e-08 34.9 0.0 3.2e-08 33.8 0.0 1.5 1 0 0 1 1 1 1 Inositol hexakisphosphate DSPc PF00782.20 ELR19872.1 - 3e-07 30.3 0.0 5.4e-07 29.5 0.0 1.4 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 ELR19872.1 - 0.00034 20.7 0.0 0.00052 20.1 0.0 1.4 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase PF00102.27 ELR19872.1 - 0.00069 19.2 0.0 0.0011 18.6 0.0 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase CDKN3 PF05706.12 ELR19872.1 - 0.0019 17.9 0.0 0.003 17.2 0.0 1.3 1 0 0 1 1 1 1 Cyclin-dependent kinase inhibitor 3 (CDKN3) Peptidase_M54 PF07998.11 ELR19873.1 - 1e-05 25.6 2.1 1.7e-05 24.9 2.1 1.3 1 0 0 1 1 1 1 Peptidase family M54 P_C PF06640.11 ELR19873.1 - 0.0013 19.0 0.8 0.0022 18.2 0.2 1.6 2 0 0 2 2 2 1 P protein C-terminus AP3D1 PF06375.11 ELR19873.1 - 0.018 15.3 4.9 0.018 15.3 4.9 1.9 3 0 0 3 3 3 0 AP-3 complex subunit delta-1 Reprolysin_4 PF13583.6 ELR19873.1 - 0.06 13.0 0.2 0.094 12.3 0.2 1.2 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like RNA_pol_Rpc4 PF05132.14 ELR19873.1 - 0.32 11.4 3.6 0.54 10.7 3.6 1.3 1 0 0 1 1 1 0 RNA polymerase III RPC4 MAS20 PF02064.15 ELR19873.1 - 6.2 6.9 13.2 0.69 10.0 8.3 1.9 2 0 0 2 2 2 0 MAS20 protein import receptor CCDC92 PF14916.6 ELR19874.1 - 0.15 11.8 2.2 0.28 11.0 2.2 1.3 1 0 0 1 1 1 0 Coiled-coil domain of unknown function WD40_alt PF14077.6 ELR19874.1 - 0.16 11.9 0.1 0.29 11.0 0.1 1.3 1 0 0 1 1 1 0 Alternative WD40 repeat motif DUF3825 PF12873.7 ELR19875.1 - 6.1e-18 65.2 0.3 4.9e-16 58.9 0.0 2.3 2 0 0 2 2 2 2 Domain of unknown function (DUF3825) BTB_2 PF02214.22 ELR19876.1 - 1.4e-14 54.2 0.0 3.6e-14 52.9 0.0 1.7 1 0 0 1 1 1 1 BTB/POZ domain BTB_3 PF16017.5 ELR19876.1 - 0.0062 16.6 0.0 0.016 15.3 0.0 1.7 1 0 0 1 1 1 1 BTB/POZ domain Sugar_tr PF00083.24 ELR19877.1 - 4.3e-36 124.8 24.3 2.3e-33 115.8 4.9 2.1 2 0 0 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 ELR19877.1 - 2.5e-29 102.3 42.0 3e-23 82.3 24.4 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.7 ELR19877.1 - 9.3e-05 21.4 19.9 0.00084 18.3 0.1 2.9 1 1 1 3 3 3 2 MFS_1 like family PhosphMutase PF10143.9 ELR19878.1 - 2.6e-38 131.6 0.0 1.1e-37 129.5 0.0 1.9 1 1 0 1 1 1 1 2,3-bisphosphoglycerate-independent phosphoglycerate mutase Metalloenzyme PF01676.18 ELR19878.1 - 1.6e-24 86.6 0.0 2.1e-24 86.3 0.0 1.1 1 0 0 1 1 1 1 Metalloenzyme superfamily WD40 PF00400.32 ELR19879.1 - 1.1e-23 83.0 21.2 8.1e-05 23.3 1.4 7.3 7 0 0 7 7 7 5 WD domain, G-beta repeat F-box-like PF12937.7 ELR19879.1 - 2.5e-08 33.7 0.2 4e-08 33.0 0.2 1.4 1 0 0 1 1 1 1 F-box-like ANAPC4_WD40 PF12894.7 ELR19879.1 - 2e-07 31.2 3.6 0.48 10.8 0.1 4.6 1 1 4 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ELR19879.1 - 2.8e-06 26.9 3.6 3e-06 26.8 0.7 2.0 1 1 1 2 2 2 1 WD40-like domain F-box PF00646.33 ELR19879.1 - 3.7e-05 23.5 0.1 7.4e-05 22.5 0.1 1.5 1 0 0 1 1 1 1 F-box domain Nup160 PF11715.8 ELR19879.1 - 0.00024 19.9 9.6 0.32 9.6 0.2 4.5 2 1 2 4 4 4 2 Nucleoporin Nup120/160 F-box_5 PF18511.1 ELR19879.1 - 0.0012 18.3 0.0 0.0031 17.0 0.0 1.7 1 0 0 1 1 1 1 F-box DUF5046 PF16465.5 ELR19879.1 - 0.0072 15.8 0.2 5.5 6.3 0.1 2.8 1 1 2 3 3 3 2 Domain of unknown function (DUF5046) NUP214 PF16755.5 ELR19879.1 - 0.042 13.1 0.1 0.079 12.2 0.1 1.4 1 0 0 1 1 1 0 Nucleoporin or Nuclear pore complex subunit NUP214=Nup159 Dsh_C PF12316.8 ELR19879.1 - 0.053 13.9 8.0 0.085 13.3 8.0 1.3 1 0 0 1 1 1 0 Segment polarity protein dishevelled (Dsh) C terminal Presenilin PF01080.17 ELR19879.1 - 0.52 9.0 12.4 0.8 8.4 12.4 1.3 1 0 0 1 1 1 0 Presenilin RR_TM4-6 PF06459.12 ELR19879.1 - 4.1 7.1 27.5 8.3 6.1 27.5 1.5 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 adh_short_C2 PF13561.6 ELR19881.1 - 8.8e-17 61.4 3.8 1e-14 54.7 3.8 2.1 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 ELR19881.1 - 1.3e-15 57.4 1.9 1.7e-15 57.0 1.9 1.2 1 0 0 1 1 1 1 short chain dehydrogenase Usp PF00582.26 ELR19882.1 - 5.7e-22 78.7 0.1 7.5e-22 78.4 0.1 1.1 1 0 0 1 1 1 1 Universal stress protein family CN_hydrolase PF00795.22 ELR19882.1 - 0.14 11.4 0.0 0.16 11.2 0.0 1.1 1 0 0 1 1 1 0 Carbon-nitrogen hydrolase F-box PF00646.33 ELR19883.1 - 4.5e-06 26.4 0.0 1.2e-05 25.1 0.0 1.8 1 0 0 1 1 1 1 F-box domain CDKN3 PF05706.12 ELR19885.1 - 8.5e-12 45.1 0.1 1.4e-11 44.3 0.0 1.3 1 1 0 1 1 1 1 Cyclin-dependent kinase inhibitor 3 (CDKN3) DSPc PF00782.20 ELR19885.1 - 5.8e-07 29.4 0.0 8.1e-07 28.9 0.0 1.2 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 ELR19885.1 - 2.2e-05 24.1 0.0 3.9e-05 23.4 0.0 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.6 ELR19885.1 - 2.7e-05 24.3 0.0 4.1e-05 23.7 0.0 1.4 1 0 0 1 1 1 1 Tyrosine phosphatase family PTPlike_phytase PF14566.6 ELR19885.1 - 0.0037 17.4 0.0 0.0071 16.5 0.0 1.4 1 0 0 1 1 1 1 Inositol hexakisphosphate U79_P34 PF03064.16 ELR19885.1 - 0.05 13.0 3.8 0.073 12.4 3.8 1.2 1 0 0 1 1 1 0 HSV U79 / HCMV P34 Init_tRNA_PT PF04179.12 ELR19885.1 - 0.18 12.1 0.1 0.57 10.5 0.0 1.8 2 0 0 2 2 2 0 Rit1 DUSP-like domain PBP_sp32 PF07222.12 ELR19885.1 - 0.32 10.4 1.4 0.45 9.9 1.4 1.2 1 0 0 1 1 1 0 Proacrosin binding protein sp32 SelP_N PF04592.14 ELR19885.1 - 5.8 6.2 14.0 8.7 5.7 14.0 1.2 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Ank_2 PF12796.7 ELR19886.1 - 6.7e-17 61.9 0.0 3.1e-11 43.7 0.0 2.2 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ELR19886.1 - 1e-15 57.9 2.5 6.6e-06 26.6 0.0 3.2 1 1 3 4 4 4 4 Ankyrin repeats (many copies) Ank_5 PF13857.6 ELR19886.1 - 5e-15 55.4 1.3 7.7e-09 35.7 0.0 3.4 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.30 ELR19886.1 - 1.1e-14 54.1 1.8 0.00012 22.4 0.1 3.4 3 0 0 3 3 3 3 Ankyrin repeat Ank_3 PF13606.6 ELR19886.1 - 1.1e-10 40.7 0.5 0.029 14.9 0.1 3.6 4 0 0 4 4 4 3 Ankyrin repeat Nop14 PF04147.12 ELR19886.1 - 3.7 5.6 9.3 4.4 5.4 9.3 1.0 1 0 0 1 1 1 0 Nop14-like family LIM PF00412.22 ELR19887.1 - 9.5e-14 51.4 3.2 1.4e-13 50.8 3.2 1.3 1 0 0 1 1 1 1 LIM domain EamA PF00892.20 ELR19888.1 - 4e-15 56.2 32.6 8.1e-10 39.0 13.6 2.7 2 1 0 2 2 2 2 EamA-like transporter family SLC35F PF06027.12 ELR19888.1 - 9.7e-06 25.3 6.9 1.4e-05 24.7 6.9 1.3 1 0 0 1 1 1 1 Solute carrier family 35 Nuc_sug_transp PF04142.15 ELR19888.1 - 2.5e-05 23.6 0.5 3.4e-05 23.2 0.5 1.3 1 0 0 1 1 1 1 Nucleotide-sugar transporter TPT PF03151.16 ELR19888.1 - 0.00057 19.3 3.8 0.00063 19.2 1.3 2.0 2 0 0 2 2 2 1 Triose-phosphate Transporter family PUNUT PF16913.5 ELR19888.1 - 0.0013 18.0 3.6 0.0013 18.0 3.6 2.8 2 1 1 3 3 3 1 Purine nucleobase transmembrane transport DUF4337 PF14235.6 ELR19888.1 - 2.2 8.4 5.7 0.8 9.8 0.1 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4337) Laminin_G_2 PF02210.24 ELR19890.1 - 0.054 14.1 0.0 2.8 8.5 0.0 3.4 4 0 0 4 4 4 0 Laminin G domain Hemerythrin PF01814.23 ELR19891.1 - 1.6e-05 25.5 9.6 0.00016 22.3 8.7 2.2 1 1 1 2 2 2 2 Hemerythrin HHE cation binding domain MORN PF02493.20 ELR19892.1 - 5.1e-94 302.9 129.2 5.3e-09 35.5 5.8 14.3 14 0 0 14 14 14 14 MORN repeat RabGGT_insert PF07711.11 ELR19892.1 - 1.6 9.3 4.2 1.9e+02 2.6 0.0 4.6 3 1 2 6 6 6 0 Rab geranylgeranyl transferase alpha-subunit, insert domain 4HBT PF03061.22 ELR19893.1 - 2.1e-13 50.4 0.9 2.9e-13 50.0 0.9 1.2 1 0 0 1 1 1 1 Thioesterase superfamily 4HBT_3 PF13622.6 ELR19893.1 - 6.4e-05 23.3 3.1 8.4e-05 22.9 3.1 1.1 1 0 0 1 1 1 1 Thioesterase-like superfamily DUF4442 PF14539.6 ELR19893.1 - 0.00036 20.7 2.6 0.0005 20.2 2.6 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4442) sCache_3_2 PF17203.4 ELR19893.1 - 0.013 15.7 0.0 0.037 14.2 0.0 1.9 1 1 0 1 1 1 0 Single cache domain 3 ApbE PF02424.15 ELR19893.1 - 0.018 14.6 0.3 0.022 14.3 0.3 1.1 1 0 0 1 1 1 0 ApbE family DUF4832 PF16116.5 ELR19894.1 - 3.3e-40 138.2 0.0 4.7e-40 137.7 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4832) DUF4874 PF16173.5 ELR19894.1 - 1.5e-35 122.2 0.0 2.1e-35 121.7 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4874) Amidinotransf PF02274.17 ELR19895.1 - 1.5e-05 24.3 0.0 1.5e-05 24.3 0.0 1.2 1 0 0 1 1 1 1 Amidinotransferase YL1 PF05764.13 ELR19896.1 - 1.2e-11 45.2 39.8 1.7e-09 38.2 39.8 2.0 1 1 0 1 1 1 1 YL1 nuclear protein Mito_carr PF00153.27 ELR19897.1 - 3.6e-09 36.4 0.1 4.3e-06 26.5 0.0 2.7 3 0 0 3 3 3 2 Mitochondrial carrier protein Nsp3_PL2pro PF12124.8 ELR19898.1 - 1 9.2 9.7 66 3.4 0.1 4.9 4 1 1 5 5 5 0 Coronavirus polyprotein cleavage domain DUF780 PF05611.11 ELR19898.1 - 4.3 8.2 28.8 4.8 8.0 5.6 3.4 1 1 2 3 3 3 0 Caenorhabditis elegans protein of unknown function (DUF780) Pentapeptide PF00805.22 ELR19899.1 - 5.6e-19 67.4 6.3 1.9e-09 37.0 1.2 2.5 1 1 0 2 2 2 2 Pentapeptide repeats (8 copies) BTB_2 PF02214.22 ELR19899.1 - 2.3e-12 47.1 0.0 4.1e-12 46.3 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain Pentapeptide_4 PF13599.6 ELR19899.1 - 2.4e-11 43.7 0.2 1.3e-08 34.9 0.1 2.0 1 1 1 2 2 2 2 Pentapeptide repeats (9 copies) Pentapeptide_3 PF13576.6 ELR19899.1 - 1.1e-06 28.7 0.0 8.5e-06 25.8 0.0 2.2 2 0 0 2 2 2 1 Pentapeptide repeats (9 copies) T2SSM PF04612.12 ELR19899.1 - 0.033 14.3 0.1 0.11 12.6 0.1 2.0 1 1 0 1 1 1 0 Type II secretion system (T2SS), protein M AP3D1 PF06375.11 ELR19900.1 - 0.033 14.4 10.7 0.16 12.2 4.4 2.6 2 0 0 2 2 2 0 AP-3 complex subunit delta-1 DUF4820 PF16091.5 ELR19900.1 - 0.056 12.8 3.4 0.17 11.2 1.7 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4820) Vfa1 PF08432.10 ELR19900.1 - 0.26 11.6 9.2 0.83 10.0 4.8 2.4 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 NST1 PF13945.6 ELR19900.1 - 1.3 9.1 13.8 3.8 7.6 0.1 2.8 3 0 0 3 3 3 0 Salt tolerance down-regulator Dicty_REP PF05086.12 ELR19900.1 - 2.8 5.8 14.2 5.2 4.9 9.5 2.3 2 0 0 2 2 2 0 Dictyostelium (Slime Mold) REP protein FAM176 PF14851.6 ELR19900.1 - 3.5 7.3 11.9 3.2 7.4 1.0 3.5 3 1 0 4 4 4 0 FAM176 family XRCC4 PF06632.12 ELR19900.1 - 3.9 6.2 10.0 11 4.7 10.0 1.8 1 0 0 1 1 1 0 DNA double-strand break repair and V(D)J recombination protein XRCC4 RNA_polI_A34 PF08208.11 ELR19900.1 - 5.9 6.9 24.2 2.5 8.2 0.3 3.2 3 0 0 3 3 3 0 DNA-directed RNA polymerase I subunit RPA34.5 DUF4820 PF16091.5 ELR19901.1 - 0.16 11.3 6.9 0.21 11.0 6.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) Nucleo_P87 PF07267.11 ELR19901.1 - 0.56 9.0 11.5 0.62 8.9 11.5 1.0 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 Borrelia_P83 PF05262.11 ELR19901.1 - 1.7 7.1 16.5 1.7 7.1 16.5 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein U79_P34 PF03064.16 ELR19901.1 - 1.8 7.9 14.5 1.9 7.8 14.5 1.1 1 0 0 1 1 1 0 HSV U79 / HCMV P34 SRP-alpha_N PF04086.13 ELR19901.1 - 3 7.7 22.4 3.2 7.6 22.4 1.0 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal SAPS PF04499.15 ELR19901.1 - 3.2 6.4 10.4 3.1 6.5 10.4 1.0 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Smg8_Smg9 PF10220.9 ELR19901.1 - 3.2 6.0 12.2 3.1 6.0 12.2 1.0 1 0 0 1 1 1 0 Smg8_Smg9 GAGA_bind PF06217.12 ELR19901.1 - 3.2 7.9 14.6 3.7 7.8 14.6 1.1 1 0 0 1 1 1 0 GAGA binding protein-like family Serinc PF03348.15 ELR19901.1 - 3.3 6.5 4.1 3.2 6.6 4.1 1.2 1 0 0 1 1 1 0 Serine incorporator (Serinc) SLC12 PF03522.15 ELR19901.1 - 4.5 6.2 15.8 5.2 6.0 15.8 1.0 1 0 0 1 1 1 0 Solute carrier family 12 Presenilin PF01080.17 ELR19901.1 - 7.9 5.1 19.8 8.8 5.0 19.8 1.1 1 0 0 1 1 1 0 Presenilin TFIIF_alpha PF05793.12 ELR19901.1 - 8.2 4.9 28.4 10 4.6 28.4 1.2 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) PA26 PF04636.13 ELR19901.1 - 9 5.1 10.0 9.1 5.1 10.0 1.0 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) DUF4604 PF15377.6 ELR19901.1 - 9.2 6.7 30.1 11 6.4 30.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4604) Pentapeptide PF00805.22 ELR19902.1 - 7.1e-20 70.3 17.7 5.8e-10 38.6 3.1 3.2 2 1 1 3 3 3 3 Pentapeptide repeats (8 copies) Pentapeptide_4 PF13599.6 ELR19902.1 - 3.1e-15 56.1 1.5 1.8e-12 47.2 0.4 2.0 1 1 1 2 2 2 2 Pentapeptide repeats (9 copies) Pentapeptide_3 PF13576.6 ELR19902.1 - 1.3e-11 44.4 0.5 4e-06 26.9 0.0 2.8 3 0 0 3 3 3 2 Pentapeptide repeats (9 copies) Glyco_hydro_47 PF01532.20 ELR19903.1 - 1.8e-143 478.7 0.0 2.1e-143 478.6 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 ADIP PF11559.8 ELR19904.1 - 5.4e-20 72.0 15.7 5.4e-20 72.0 15.7 2.8 3 0 0 3 3 3 1 Afadin- and alpha -actinin-Binding YjbH PF06082.11 ELR19904.1 - 2 7.1 7.3 2.8 6.6 7.3 1.2 1 0 0 1 1 1 0 Exopolysaccharide biosynthesis protein YbjH ERM PF00769.19 ELR19904.1 - 6.2 6.6 37.2 55 3.5 37.2 2.2 1 1 0 1 1 1 0 Ezrin/radixin/moesin family ADIP PF11559.8 ELR19905.1 - 1.2e-20 74.2 15.3 1.3e-20 74.0 15.3 1.1 1 0 0 1 1 1 1 Afadin- and alpha -actinin-Binding Exonuc_VII_L PF02601.15 ELR19905.1 - 0.72 9.4 11.4 0.87 9.1 11.4 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit ERM PF00769.19 ELR19905.1 - 1.1 9.0 25.6 1.3 8.8 25.6 1.1 1 0 0 1 1 1 0 Ezrin/radixin/moesin family FapA PF03961.13 ELR19905.1 - 1.5 7.3 12.7 1.7 7.1 12.7 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A PhoU PF01895.19 ELR19905.1 - 1.6 9.2 5.6 5.7 7.5 0.2 3.0 2 1 1 3 3 3 0 PhoU domain FUSC PF04632.12 ELR19905.1 - 2.1 6.8 4.1 2.3 6.6 4.1 1.2 1 0 0 1 1 1 0 Fusaric acid resistance protein family DUF4407 PF14362.6 ELR19905.1 - 6.2 6.1 13.2 9.5 5.5 13.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) RhoGAP PF00620.27 ELR19906.1 - 4.7e-38 130.4 0.0 1.3e-37 129.0 0.0 1.8 1 1 0 1 1 1 1 RhoGAP domain NT5C PF06941.12 ELR19906.1 - 0.00015 21.7 0.0 0.00027 20.9 0.0 1.3 1 0 0 1 1 1 1 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C) La PF05383.17 ELR19906.1 - 0.028 14.5 0.0 0.067 13.3 0.0 1.6 1 0 0 1 1 1 0 La domain CPSF_A PF03178.15 ELR19906.1 - 0.052 12.8 0.0 0.086 12.1 0.0 1.3 1 0 0 1 1 1 0 CPSF A subunit region WD40 PF00400.32 ELR19906.1 - 4.2 8.4 16.4 0.39 11.7 0.2 5.1 5 0 0 5 5 5 0 WD domain, G-beta repeat Totivirus_coat PF05518.11 ELR19907.1 - 4.9 5.1 9.3 11 4.0 9.3 1.5 1 0 0 1 1 1 0 Totivirus coat protein Glyco_trans_1_2 PF13524.6 ELR19907.1 - 7.8 7.0 8.8 0.71 10.3 1.3 2.7 2 0 0 2 2 2 0 Glycosyl transferases group 1 Pentapeptide PF00805.22 ELR19908.1 - 1.3e-18 66.2 12.7 9.9e-10 37.9 0.5 3.4 1 1 2 3 3 3 3 Pentapeptide repeats (8 copies) Pentapeptide_4 PF13599.6 ELR19908.1 - 3.5e-09 36.7 0.1 1.2e-07 31.7 0.0 2.2 1 1 1 2 2 2 1 Pentapeptide repeats (9 copies) Pentapeptide_3 PF13576.6 ELR19908.1 - 1.1e-06 28.7 3.3 0.0025 17.9 0.5 3.4 1 1 3 4 4 4 4 Pentapeptide repeats (9 copies) BTB_2 PF02214.22 ELR19908.1 - 8.7e-05 22.8 0.0 0.00018 21.8 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain MerE PF05052.12 ELR19909.1 - 1.1 9.3 9.3 0.064 13.2 2.0 2.6 2 1 1 3 3 3 0 MerE protein MgtC PF02308.16 ELR19909.1 - 5.9 7.3 17.6 0.027 14.8 6.8 2.6 3 1 1 4 4 4 0 MgtC family Phasin PF05597.11 ELR19911.1 - 0.29 11.1 9.5 1.6 8.7 4.0 2.4 1 1 0 2 2 2 0 Poly(hydroxyalcanoate) granule associated protein (phasin) IBN_N PF03810.19 ELR19913.1 - 4e-07 29.9 0.3 1.6e-06 28.0 0.3 2.2 1 0 0 1 1 1 1 Importin-beta N-terminal domain CRM1_C PF08767.11 ELR19913.1 - 0.00077 18.7 0.0 0.0032 16.7 0.0 2.1 2 0 0 2 2 2 1 CRM1 C terminal DUF3535 PF12054.8 ELR19914.1 - 3e-72 244.3 0.6 5.1e-71 240.2 0.3 3.0 3 0 0 3 3 3 1 Domain of unknown function (DUF3535) SNF2_N PF00176.23 ELR19914.1 - 7.6e-53 179.4 0.1 1.2e-51 175.6 0.0 2.6 1 1 1 2 2 2 1 SNF2 family N-terminal domain Helicase_C PF00271.31 ELR19914.1 - 1.4e-16 60.8 0.0 5.7e-16 58.9 0.0 2.1 1 0 0 1 1 1 1 Helicase conserved C-terminal domain HEAT PF02985.22 ELR19914.1 - 1.5e-10 40.4 15.2 0.96 9.9 0.0 9.9 10 0 0 10 10 10 4 HEAT repeat Vac14_Fab1_bd PF12755.7 ELR19914.1 - 2.6e-06 27.9 0.0 0.13 12.8 0.0 3.9 3 1 1 4 4 4 2 Vacuolar 14 Fab1-binding region UME PF08064.13 ELR19914.1 - 0.032 14.1 1.3 19 5.2 0.0 4.7 5 1 0 5 5 5 0 UME (NUC010) domain HEAT_EZ PF13513.6 ELR19914.1 - 0.035 14.6 20.4 0.065 13.8 0.0 7.4 7 0 0 7 7 7 0 HEAT-like repeat 2OG-FeII_Oxy_4 PF13661.6 ELR19914.1 - 0.043 14.5 0.0 0.11 13.2 0.0 1.6 1 0 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily DUF3385 PF11865.8 ELR19914.1 - 0.077 12.9 2.4 2.9 7.8 0.1 3.6 4 0 0 4 4 4 0 Domain of unknown function (DUF3385) DUF1258 PF06869.12 ELR19914.1 - 0.13 11.8 0.0 0.78 9.2 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1258) HEAT_2 PF13646.6 ELR19914.1 - 0.18 12.2 21.3 1.4 9.3 0.1 7.2 8 1 0 8 8 8 0 HEAT repeats SMAP PF15477.6 ELR19915.1 - 4e-10 40.5 0.1 4e-10 40.5 0.1 3.1 3 1 0 3 3 3 1 Small acidic protein family EF-hand_1 PF00036.32 ELR19916.1 - 4.8e-20 69.5 3.4 5.7e-05 22.4 0.0 4.4 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.6 ELR19916.1 - 1.5e-18 65.0 1.6 0.00036 20.2 0.0 4.4 4 0 0 4 4 4 3 EF-hand domain EF-hand_7 PF13499.6 ELR19916.1 - 4.4e-17 62.3 0.7 3.5e-09 37.0 0.1 3.1 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_8 PF13833.6 ELR19916.1 - 1.3e-12 47.4 3.3 0.00042 20.1 0.1 3.4 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.6 ELR19916.1 - 1.7e-12 46.2 4.2 0.0011 18.4 0.1 4.1 4 0 0 4 4 4 3 EF hand EF-hand_4 PF12763.7 ELR19916.1 - 0.034 14.1 0.0 0.22 11.5 0.0 2.2 2 1 1 3 3 3 0 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.6 ELR19916.1 - 0.043 14.1 0.0 0.77 10.1 0.0 2.7 3 0 0 3 3 3 0 EF-hand domain SPARC_Ca_bdg PF10591.9 ELR19916.1 - 0.066 13.5 0.3 35 4.8 0.0 3.0 2 1 1 3 3 3 0 Secreted protein acidic and rich in cysteine Ca binding region SPT16 PF08644.11 ELR19917.1 - 4.1e-47 160.1 0.8 1.4e-46 158.4 0.0 2.3 2 0 0 2 2 2 1 FACT complex subunit (SPT16/CDC68) Peptidase_M24 PF00557.24 ELR19917.1 - 1.4e-33 116.4 0.0 2.2e-33 115.7 0.0 1.3 1 0 0 1 1 1 1 Metallopeptidase family M24 FACT-Spt16_Nlob PF14826.6 ELR19917.1 - 1.2e-32 112.9 0.1 5.1e-32 110.9 0.0 2.1 2 0 0 2 2 2 1 FACT complex subunit SPT16 N-terminal lobe domain Rtt106 PF08512.12 ELR19917.1 - 8.2e-07 29.4 0.2 3.6e-06 27.3 0.2 2.0 1 1 0 1 1 1 1 Histone chaperone Rttp106-like Histone PF00125.24 ELR19918.1 - 1.9e-50 170.6 1.3 2.1e-50 170.4 1.3 1.0 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-T_C PF15511.6 ELR19918.1 - 0.00012 22.2 0.1 0.00022 21.3 0.1 1.5 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold CENP-S PF15630.6 ELR19918.1 - 0.00053 20.3 0.0 0.00085 19.7 0.0 1.3 1 0 0 1 1 1 1 CENP-S protein PAF PF15715.5 ELR19918.1 - 0.0016 19.0 1.3 0.0019 18.8 1.3 1.2 1 0 0 1 1 1 1 PCNA-associated factor histone like domain FtsK_gamma PF09397.10 ELR19919.1 - 2.4e-09 36.9 0.0 0.0026 17.5 0.0 2.5 2 0 0 2 2 2 2 Ftsk gamma domain GFA PF04828.14 ELR19920.1 - 1e-06 29.0 0.2 1.6e-06 28.4 0.2 1.4 1 1 0 1 1 1 1 Glutathione-dependent formaldehyde-activating enzyme CD20 PF04103.15 ELR19921.1 - 0.016 15.3 1.9 0.066 13.3 0.3 1.9 1 1 0 2 2 2 0 CD20-like family HRG PF16954.5 ELR19921.1 - 0.16 12.4 1.2 0.98 9.9 0.4 2.2 2 1 0 2 2 2 0 Haem-transporter, endosomal/lysosomal, haem-responsive gene Vitellogenin_N PF01347.22 ELR19922.1 - 0.029 12.8 2.6 0.19 10.1 0.2 2.1 2 0 0 2 2 2 0 Lipoprotein amino terminal region OCD_Mu_crystall PF02423.15 ELR19923.1 - 1.1e-66 224.9 8.3 1.4e-66 224.7 8.3 1.1 1 0 0 1 1 1 1 Ornithine cyclodeaminase/mu-crystallin family Shikimate_DH PF01488.20 ELR19923.1 - 6.6e-08 32.7 0.5 3.3e-07 30.4 0.5 2.1 1 1 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase THF_DHG_CYH_C PF02882.19 ELR19923.1 - 0.029 13.7 0.6 0.072 12.4 0.2 1.8 1 1 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain ParBc PF02195.18 ELR19924.1 - 6.9e-08 32.7 0.0 9.4e-08 32.3 0.0 1.2 1 0 0 1 1 1 1 ParB-like nuclease domain EF-hand_5 PF13202.6 ELR19925.1 - 7.7e-13 47.3 0.0 3.1e-05 23.2 0.0 3.3 3 0 0 3 3 3 2 EF hand EF-hand_1 PF00036.32 ELR19925.1 - 2e-10 39.4 0.0 0.00041 19.7 0.0 3.1 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.6 ELR19925.1 - 5.5e-10 38.4 0.1 0.0015 18.3 0.0 2.7 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.6 ELR19925.1 - 7.1e-09 36.0 0.0 1.5e-08 34.9 0.0 1.5 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.6 ELR19925.1 - 3.5e-06 26.7 0.1 0.00075 19.3 0.0 2.3 1 1 1 2 2 2 2 EF-hand domain pair Ribosomal_L2_C PF03947.18 ELR19925.1 - 0.11 12.7 0.3 0.21 11.8 0.3 1.4 1 0 0 1 1 1 0 Ribosomal Proteins L2, C-terminal domain SPARC_Ca_bdg PF10591.9 ELR19925.1 - 0.18 12.1 0.0 0.45 10.8 0.0 1.7 1 1 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region NinG PF05766.12 ELR19926.1 - 5.5 6.9 14.9 11 5.9 14.9 1.4 1 0 0 1 1 1 0 Bacteriophage Lambda NinG protein RhoGAP PF00620.27 ELR19927.1 - 3.9e-37 127.4 0.0 7.4e-37 126.5 0.0 1.4 1 0 0 1 1 1 1 RhoGAP domain SH3_1 PF00018.28 ELR19927.1 - 0.0012 18.5 1.6 0.0088 15.6 0.7 2.7 2 1 0 2 2 2 1 SH3 domain SH3_2 PF07653.17 ELR19927.1 - 0.0041 16.8 0.2 0.04 13.6 0.2 2.5 1 1 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.6 ELR19927.1 - 0.012 15.4 3.1 0.16 11.9 1.0 2.8 2 1 0 2 2 2 0 Variant SH3 domain EF-hand_7 PF13499.6 ELR19928.1 - 2.7e-16 59.8 4.9 1.9e-08 34.6 0.1 3.1 1 1 2 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.6 ELR19928.1 - 7.8e-13 47.3 1.2 4.2e-05 22.8 0.0 3.9 4 0 0 4 4 4 2 EF hand EF-hand_1 PF00036.32 ELR19928.1 - 2.2e-11 42.4 0.2 0.00076 18.9 0.0 4.2 4 0 0 4 4 4 2 EF hand EF-hand_6 PF13405.6 ELR19928.1 - 9.1e-11 40.8 0.1 0.0013 18.5 0.0 3.6 4 0 0 4 4 4 2 EF-hand domain EF-hand_8 PF13833.6 ELR19928.1 - 8.1e-09 35.2 0.4 0.00018 21.3 0.0 3.5 3 1 1 4 4 4 2 EF-hand domain pair SPARC_Ca_bdg PF10591.9 ELR19928.1 - 0.02 15.2 0.1 0.08 13.3 0.0 2.0 1 1 2 3 3 3 0 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_9 PF14658.6 ELR19928.1 - 0.025 14.9 0.0 1 9.7 0.0 2.6 2 1 0 2 2 2 0 EF-hand domain RhoGEF PF00621.20 ELR19929.1 - 2.7e-49 167.9 1.2 2.7e-49 167.9 1.2 1.9 2 0 0 2 2 2 1 RhoGEF domain PH_13 PF16652.5 ELR19929.1 - 5.5e-07 29.5 0.0 5.5e-07 29.5 0.0 1.8 2 1 0 2 2 2 1 Pleckstrin homology domain IQ_SEC7_PH PF16453.5 ELR19929.1 - 0.00011 22.2 0.0 0.00026 21.0 0.0 1.7 1 0 0 1 1 1 1 PH domain PH PF00169.29 ELR19929.1 - 0.0003 21.3 0.0 0.00084 19.8 0.0 1.8 1 0 0 1 1 1 1 PH domain DUF4248 PF14053.6 ELR19929.1 - 0.87 9.7 3.5 0.37 10.9 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4248) COMM_domain PF07258.14 ELR19930.1 - 8.1e-15 54.7 0.1 1.9e-14 53.5 0.1 1.6 1 0 0 1 1 1 1 COMM domain Leptin PF02024.15 ELR19931.1 - 0.025 14.4 0.7 0.044 13.6 0.7 1.3 1 0 0 1 1 1 0 Leptin SH3_2 PF07653.17 ELR19932.1 - 6.4e-05 22.6 0.0 0.00012 21.7 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.6 ELR19932.1 - 0.00091 19.0 0.0 0.002 17.9 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 ELR19932.1 - 0.014 15.0 0.0 0.028 14.0 0.0 1.5 1 0 0 1 1 1 0 SH3 domain PCMT PF01135.19 ELR19933.1 - 3.2e-59 200.2 0.0 8.8e-57 192.2 0.0 2.0 1 1 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) PrmA PF06325.13 ELR19933.1 - 0.0075 15.7 0.0 0.011 15.2 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_23 PF13489.6 ELR19933.1 - 0.18 11.7 0.0 0.28 11.0 0.0 1.4 1 1 0 1 1 1 0 Methyltransferase domain DnaJ PF00226.31 ELR19934.1 - 1.1e-21 76.7 0.1 1.9e-21 75.9 0.1 1.4 1 0 0 1 1 1 1 DnaJ domain DUF1510 PF07423.11 ELR19934.1 - 0.065 13.4 0.2 0.14 12.3 0.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1510) TMEM65 PF10507.9 ELR19934.1 - 0.13 12.2 0.4 0.13 12.2 0.4 1.8 2 0 0 2 2 2 0 Transmembrane protein 65 Radial_spoke_3 PF06098.11 ELR19934.1 - 4.8 6.4 19.1 1.4 8.1 11.5 2.2 2 0 0 2 2 2 0 Radial spoke protein 3 Mpp10 PF04006.12 ELR19935.1 - 0.0036 15.8 4.8 0.005 15.4 4.8 1.1 1 0 0 1 1 1 1 Mpp10 protein zf-4CXXC_R1 PF10497.9 ELR19935.1 - 0.0073 16.5 9.9 0.016 15.4 9.9 1.5 1 0 0 1 1 1 1 Zinc-finger domain of monoamine-oxidase A repressor R1 Nop14 PF04147.12 ELR19935.1 - 0.075 11.3 12.1 0.12 10.6 12.1 1.2 1 0 0 1 1 1 0 Nop14-like family Paramyxo_ncap PF00973.19 ELR19935.1 - 0.68 8.8 1.9 1 8.2 1.9 1.1 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein BUD22 PF09073.10 ELR19935.1 - 2 7.7 17.6 8.3 5.6 17.6 2.0 1 0 0 1 1 1 0 BUD22 Kelch_4 PF13418.6 ELR19937.1 - 1.7e-44 149.5 4.8 3.2e-07 30.3 0.0 6.5 6 0 0 6 6 6 6 Galactose oxidase, central domain Kelch_1 PF01344.25 ELR19937.1 - 1.4e-41 139.9 13.7 5e-10 38.8 0.0 6.5 6 0 0 6 6 6 6 Kelch motif Kelch_3 PF13415.6 ELR19937.1 - 3e-39 132.6 8.8 4.1e-08 33.3 0.0 7.1 7 0 0 7 7 7 5 Galactose oxidase, central domain Kelch_6 PF13964.6 ELR19937.1 - 2.5e-32 110.1 6.5 4.2e-07 30.0 0.0 6.5 5 1 1 6 6 6 6 Kelch motif Kelch_2 PF07646.15 ELR19937.1 - 6e-31 105.2 6.2 2e-06 27.5 0.0 6.8 6 0 0 6 6 6 6 Kelch motif Kelch_5 PF13854.6 ELR19937.1 - 5.3e-29 99.7 13.3 1.2e-05 25.2 0.0 6.6 6 0 0 6 6 6 6 Kelch motif BTB PF00651.31 ELR19937.1 - 2.3e-26 92.2 0.0 2.2e-10 40.8 0.0 3.4 3 0 0 3 3 3 3 BTB/POZ domain Glyco_transf_10 PF00852.19 ELR19938.1 - 7.9e-38 129.9 0.0 1.3e-37 129.2 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Laminin_G_3 PF13385.6 ELR19938.1 - 3.4e-21 76.0 0.1 6.4e-21 75.1 0.1 1.5 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Glyco_tran_10_N PF17039.5 ELR19938.1 - 5.9e-10 39.6 0.0 1.1e-09 38.7 0.0 1.5 1 0 0 1 1 1 1 Fucosyltransferase, N-terminal Pentaxin PF00354.17 ELR19938.1 - 0.16 11.6 0.0 0.29 10.8 0.0 1.3 1 0 0 1 1 1 0 Pentaxin family C2 PF00168.30 ELR19940.1 - 1.7e-22 79.7 0.1 4.6e-22 78.3 0.1 1.7 1 0 0 1 1 1 1 C2 domain RGS PF00615.19 ELR19940.1 - 3e-21 75.9 3.8 5.9e-21 74.9 0.9 2.3 2 0 0 2 2 2 1 Regulator of G protein signaling domain CEP76-C2 PF15627.6 ELR19940.1 - 0.016 14.7 0.4 0.15 11.6 0.0 2.3 2 0 0 2 2 2 0 CEP76 C2 domain DUF4298 PF14131.6 ELR19940.1 - 1.1 9.3 3.2 9.4 6.3 1.4 2.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4298) GIT_CC PF16559.5 ELR19940.1 - 1.9 8.4 6.3 2 8.3 1.6 2.7 2 0 0 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor FapA PF03961.13 ELR19940.1 - 2.4 6.7 4.4 5.9 5.4 1.3 2.1 2 0 0 2 2 2 0 Flagellar Assembly Protein A Herpes_BLRF2 PF05812.12 ELR19940.1 - 5.5 7.1 10.1 0.39 10.9 3.8 2.4 2 0 0 2 2 2 0 Herpesvirus BLRF2 protein YabA PF06156.13 ELR19940.1 - 6.8 7.4 6.4 17 6.1 1.8 2.7 3 0 0 3 3 3 0 Initiation control protein YabA Hydrolase_6 PF13344.6 ELR19941.1 - 1.2e-22 79.9 0.0 2.9e-22 78.7 0.0 1.7 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 ELR19941.1 - 6.9e-22 77.3 0.0 2.1e-21 75.8 0.0 1.8 2 0 0 2 2 2 1 HAD-hyrolase-like HAD_2 PF13419.6 ELR19941.1 - 6e-05 23.2 0.0 0.047 13.8 0.0 2.3 2 0 0 2 2 2 2 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 ELR19941.1 - 0.00064 20.1 0.0 1.5 9.1 0.0 2.9 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase PGP_phosphatase PF09419.10 ELR19941.1 - 0.029 14.0 0.0 0.079 12.6 0.0 1.7 2 0 0 2 2 2 0 Mitochondrial PGP phosphatase RasGEF PF00617.19 ELR19942.1 - 3.8e-52 177.0 1.7 6.5e-52 176.3 1.7 1.4 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 ELR19942.1 - 2.4e-21 75.9 1.1 2.4e-21 75.9 1.1 2.5 2 0 0 2 2 2 1 RasGEF N-terminal motif FERM_f0 PF16511.5 ELR19942.1 - 1.9e-11 44.1 0.3 5.6e-05 23.4 0.0 4.8 5 2 1 6 6 6 2 N-terminal or F0 domain of Talin-head FERM VWA_3 PF13768.6 ELR19942.1 - 0.0022 18.0 0.1 0.087 12.8 0.0 2.6 2 0 0 2 2 2 1 von Willebrand factor type A domain ubiquitin PF00240.23 ELR19942.1 - 0.11 12.2 0.1 21 5.0 0.0 2.8 2 0 0 2 2 2 0 Ubiquitin family Pkinase_Tyr PF07714.17 ELR19943.1 - 7.6e-60 202.4 0.0 9.5e-60 202.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ELR19943.1 - 1.6e-50 171.9 0.0 2.2e-50 171.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain SH2 PF00017.24 ELR19943.1 - 2.2e-15 56.5 0.0 4e-15 55.7 0.0 1.5 1 0 0 1 1 1 1 SH2 domain Pkinase_fungal PF17667.1 ELR19943.1 - 0.021 13.6 0.0 0.03 13.1 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase APH PF01636.23 ELR19943.1 - 0.025 14.5 0.0 0.053 13.4 0.0 1.5 1 0 0 1 1 1 0 Phosphotransferase enzyme family Haspin_kinase PF12330.8 ELR19943.1 - 0.12 11.3 0.2 1 8.2 0.0 2.3 3 0 0 3 3 3 0 Haspin like kinase domain PP2C PF00481.21 ELR19944.1 - 1e-58 199.0 0.0 1e-58 199.0 0.0 2.2 2 0 0 2 2 2 1 Protein phosphatase 2C CENP-N PF05238.13 ELR19944.1 - 0.027 13.8 11.6 0.26 10.5 7.7 2.3 2 0 0 2 2 2 0 Kinetochore protein CHL4 like DUF2052 PF09747.9 ELR19944.1 - 0.066 13.3 18.8 0.16 12.0 18.8 1.6 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) Borrelia_P83 PF05262.11 ELR19944.1 - 0.17 10.4 16.6 0.25 9.8 16.6 1.2 1 0 0 1 1 1 0 Borrelia P83/100 protein DUF2201_N PF13203.6 ELR19944.1 - 0.53 9.8 8.1 1.6 8.3 7.9 2.0 2 1 0 2 2 2 0 Putative metallopeptidase domain AAA_11 PF13086.6 ELR19944.1 - 0.72 9.6 16.9 0.22 11.3 13.3 1.9 2 0 0 2 2 2 0 AAA domain SAPS PF04499.15 ELR19944.1 - 1 8.1 15.1 0.11 11.3 10.6 1.5 2 0 0 2 2 2 0 SIT4 phosphatase-associated protein RR_TM4-6 PF06459.12 ELR19944.1 - 1.3 8.8 23.4 3.5 7.4 23.4 1.7 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 FAM60A PF15396.6 ELR19944.1 - 1.8 8.5 16.7 0.31 11.0 9.8 2.4 2 0 0 2 2 2 0 Protein Family FAM60A SLC12 PF03522.15 ELR19944.1 - 2.3 7.2 17.3 5.4 5.9 17.3 1.5 1 0 0 1 1 1 0 Solute carrier family 12 DUF2151 PF10221.9 ELR19944.1 - 3.5 6.1 18.6 1.2 7.7 12.9 2.1 2 0 0 2 2 2 0 Cell cycle and development regulator RNA_polI_A34 PF08208.11 ELR19944.1 - 3.7 7.6 40.3 15 5.6 40.3 2.1 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 FGF-BP1 PF06473.12 ELR19944.1 - 4 7.2 20.1 12 5.6 19.4 2.3 2 0 0 2 2 2 0 FGF binding protein 1 (FGF-BP1) Band_3_cyto PF07565.13 ELR19944.1 - 4.1 7.1 11.8 1.3 8.8 5.6 2.4 2 0 0 2 2 2 0 Band 3 cytoplasmic domain CDC45 PF02724.14 ELR19944.1 - 7 4.8 26.2 13 3.9 26.2 1.3 1 0 0 1 1 1 0 CDC45-like protein MFS_1 PF07690.16 ELR19945.1 - 1.4e-26 93.3 40.8 4.8e-19 68.5 11.2 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 ELR19945.1 - 4.1e-11 42.1 27.6 1.4e-09 37.1 27.6 3.5 1 1 0 1 1 1 1 MFS/sugar transport protein Sugar_tr PF00083.24 ELR19945.1 - 5.2e-07 28.9 6.0 5.2e-07 28.9 6.0 2.4 2 2 0 2 2 2 1 Sugar (and other) transporter BT1 PF03092.16 ELR19945.1 - 4e-06 25.4 11.7 8e-05 21.1 0.3 2.4 2 0 0 2 2 2 2 BT1 family MFS_1_like PF12832.7 ELR19945.1 - 0.0012 17.8 11.1 0.34 9.7 0.0 3.2 1 1 1 3 3 3 2 MFS_1 like family PTR2 PF00854.21 ELR19945.1 - 3.9 6.2 7.3 1.2 7.9 1.1 2.6 3 0 0 3 3 3 0 POT family RHH_5 PF07878.11 ELR19946.1 - 0.004 17.0 0.1 0.011 15.6 0.1 1.6 1 0 0 1 1 1 1 CopG-like RHH_1 or ribbon-helix-helix domain, RHH_5 SapB_1 PF05184.15 ELR19946.1 - 0.15 12.1 0.1 0.37 10.9 0.1 1.6 1 0 0 1 1 1 0 Saposin-like type B, region 1 IQCJ-SCHIP1 PF15157.6 ELR19947.1 - 2.1 8.1 5.0 6.4 6.6 5.0 1.8 1 0 0 1 1 1 0 Fusion protein IQCJ-SCHIP1 with IQ-like motif Pkinase PF00069.25 ELR19948.1 - 6.2e-28 97.9 0.0 7.9e-28 97.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR19948.1 - 5.1e-15 55.5 0.0 7.8e-15 54.9 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 ELR19948.1 - 2.1e-10 39.9 0.1 3.9e-10 39.1 0.1 1.4 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 ELR19948.1 - 0.0012 18.8 0.6 0.015 15.2 0.0 2.3 2 0 0 2 2 2 1 Phosphotransferase enzyme family Kinase-like PF14531.6 ELR19948.1 - 0.004 16.5 0.0 0.22 10.8 0.0 2.2 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.14 ELR19948.1 - 0.0054 16.1 0.1 0.01 15.2 0.1 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pox_ser-thr_kin PF05445.11 ELR19948.1 - 0.0072 15.3 0.1 0.01 14.8 0.1 1.1 1 0 0 1 1 1 1 Poxvirus serine/threonine protein kinase PGC7_Stella PF15549.6 ELR19948.1 - 2 8.4 5.3 3.4 7.6 5.3 1.3 1 0 0 1 1 1 0 PGC7/Stella/Dppa3 domain Aminotran_1_2 PF00155.21 ELR19949.1 - 1e-25 90.7 0.0 1.2e-25 90.5 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Pkinase PF00069.25 ELR19950.1 - 8.2e-16 58.2 0.0 1.1e-15 57.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_fungal PF17667.1 ELR19950.1 - 2.8e-09 36.3 0.0 2.8e-09 36.3 0.0 1.6 2 0 0 2 2 2 1 Fungal protein kinase Pkinase_Tyr PF07714.17 ELR19950.1 - 6.3e-07 28.9 0.0 9.2e-07 28.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 ELR19950.1 - 0.017 15.0 2.3 0.023 14.6 0.0 2.1 2 1 0 2 2 2 0 Phosphotransferase enzyme family Kdo PF06293.14 ELR19950.1 - 0.02 14.3 0.1 0.044 13.1 0.1 1.6 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pox_ser-thr_kin PF05445.11 ELR19950.1 - 0.082 11.9 0.1 0.11 11.4 0.1 1.1 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Aminotran_1_2 PF00155.21 ELR19951.1 - 7.4e-58 196.5 0.0 8.7e-58 196.2 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.19 ELR19951.1 - 4.7e-06 25.8 0.0 0.0011 18.0 0.0 2.1 2 0 0 2 2 2 2 Aminotransferase class-V DegT_DnrJ_EryC1 PF01041.17 ELR19951.1 - 0.00081 18.8 0.0 0.0015 17.9 0.0 1.4 1 1 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Cys_Met_Meta_PP PF01053.20 ELR19951.1 - 0.0012 17.5 0.0 0.0022 16.6 0.0 1.4 1 1 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Beta_elim_lyase PF01212.21 ELR19951.1 - 0.0023 17.3 0.0 0.0035 16.7 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase AKAP7_NLS PF10469.9 ELR19953.1 - 3.4e-52 177.4 0.0 4.2e-52 177.0 0.0 1.1 1 0 0 1 1 1 1 AKAP7 2'5' RNA ligase-like domain KH_1 PF00013.29 ELR19953.1 - 1.2e-10 41.1 0.4 1.2e-10 41.1 0.4 1.8 2 0 0 2 2 2 1 KH domain LigT_PEase PF02834.16 ELR19953.1 - 0.029 14.5 0.0 0.4 10.9 0.0 2.7 3 0 0 3 3 3 0 LigT like Phosphoesterase F-box-like PF12937.7 ELR19954.1 - 4.2e-08 33.0 1.3 5.6e-08 32.6 0.1 1.9 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 ELR19954.1 - 3.7e-06 26.7 0.0 3.7e-06 26.7 0.0 2.0 2 0 0 2 2 2 1 F-box domain F-box_4 PF15966.5 ELR19954.1 - 4.1e-05 23.4 0.3 8.3e-05 22.5 0.0 1.7 2 0 0 2 2 2 1 F-box BTK PF00779.19 ELR19954.1 - 0.00056 19.7 6.3 0.00063 19.5 2.4 2.3 2 0 0 2 2 2 1 BTK motif Dirigent PF03018.14 ELR19955.1 - 7.3e-05 22.6 0.0 8.1e-05 22.5 0.0 1.1 1 0 0 1 1 1 1 Dirigent-like protein RabGAP-TBC PF00566.18 ELR19956.1 - 1.9e-39 135.6 0.3 1.9e-39 135.6 0.3 1.7 2 0 0 2 2 2 1 Rab-GTPase-TBC domain Ank_2 PF12796.7 ELR19956.1 - 7.2e-15 55.3 0.1 4.6e-12 46.4 0.1 2.7 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ELR19956.1 - 7.7e-11 42.3 0.1 1.6e-06 28.5 0.1 3.0 3 0 0 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.30 ELR19956.1 - 1.1e-09 38.2 2.8 0.00031 21.1 0.1 4.6 4 0 0 4 4 4 2 Ankyrin repeat Ank_5 PF13857.6 ELR19956.1 - 2.6e-07 30.8 1.5 1.4e-05 25.3 0.2 3.6 3 1 1 4 4 4 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 ELR19956.1 - 2.9e-07 30.3 0.1 0.0033 17.8 0.0 4.2 4 0 0 4 4 4 1 Ankyrin repeat SR-25 PF10500.9 ELR19956.1 - 0.0029 17.2 4.7 0.0029 17.2 4.7 10.2 5 3 7 12 12 12 1 Nuclear RNA-splicing-associated protein PPP4R2 PF09184.11 ELR19956.1 - 0.0031 17.2 2.9 0.0031 17.2 2.9 5.0 5 0 0 5 5 5 1 PPP4R2 DAG1 PF05454.11 ELR19956.1 - 1.2 8.4 2.9 0.62 9.4 0.0 1.9 2 0 0 2 2 2 0 Dystroglycan (Dystrophin-associated glycoprotein 1) DAGK_cat PF00781.24 ELR19957.1 - 3.7e-28 97.7 0.0 9.3e-28 96.4 0.0 1.7 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain Peptidase_C92 PF05708.12 ELR19959.1 - 2.3e-11 44.1 0.0 8.4e-11 42.2 0.0 1.9 2 0 0 2 2 2 1 Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family TFIIA PF03153.13 ELR19959.1 - 0.00028 21.0 21.3 0.00028 21.0 21.3 1.8 2 0 0 2 2 2 1 Transcription factor IIA, alpha/beta subunit C2 PF00168.30 ELR19959.1 - 0.0092 16.3 0.0 3.5 8.0 0.0 2.7 3 0 0 3 3 3 2 C2 domain Zip PF02535.22 ELR19959.1 - 0.36 10.0 5.7 0.34 10.1 3.6 1.9 2 0 0 2 2 2 0 ZIP Zinc transporter CCSAP PF15748.5 ELR19959.1 - 6.2 6.9 15.5 3.6 7.7 9.1 2.6 2 0 0 2 2 2 0 Centriole, cilia and spindle-associated UQ_con PF00179.26 ELR19960.1 - 1.8e-11 43.9 0.0 1.4e-10 41.0 0.0 2.3 2 0 0 2 2 2 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 ELR19960.1 - 0.0031 17.2 0.0 0.0062 16.2 0.0 1.5 1 0 0 1 1 1 1 Prokaryotic E2 family B BUD22 PF09073.10 ELR19960.1 - 0.0083 15.5 14.6 0.011 15.1 14.6 1.1 1 0 0 1 1 1 1 BUD22 RWD PF05773.22 ELR19960.1 - 0.043 14.1 0.2 0.11 12.8 0.0 1.9 2 0 0 2 2 2 0 RWD domain PAC1 PF16094.5 ELR19960.1 - 1 8.5 3.8 6.5 5.8 0.5 2.2 2 0 0 2 2 2 0 Proteasome assembly chaperone 4 GEN1_C PF18380.1 ELR19960.1 - 2.7 8.9 7.9 2.8 8.9 0.1 2.5 2 0 0 2 2 2 0 Holliday junction resolvase Gen1 C-terminal domain CENP-B_dimeris PF09026.10 ELR19960.1 - 7.6 7.0 10.8 12 6.4 9.3 2.1 2 0 0 2 2 2 0 Centromere protein B dimerisation domain PH PF00169.29 ELR19961.1 - 2.4e-15 56.9 0.0 3.5e-15 56.4 0.0 1.2 1 0 0 1 1 1 1 PH domain HMA PF00403.26 ELR19961.1 - 3.5e-09 37.0 1.2 6.3e-09 36.1 0.4 1.9 3 0 0 3 3 3 1 Heavy-metal-associated domain PH_3 PF14593.6 ELR19961.1 - 1.4e-07 31.5 0.0 1.2e-06 28.6 0.0 2.0 2 0 0 2 2 2 1 PH domain PH_11 PF15413.6 ELR19961.1 - 2.6e-06 27.8 1.3 2.7e-05 24.5 1.3 2.2 1 1 0 1 1 1 1 Pleckstrin homology domain PH_8 PF15409.6 ELR19961.1 - 0.021 15.1 0.1 0.1 12.9 0.0 2.1 1 1 1 2 2 2 0 Pleckstrin homology domain Jas PF16135.5 ELR19961.1 - 0.051 13.7 0.2 0.16 12.2 0.2 1.8 1 0 0 1 1 1 0 TPL-binding domain in jasmonate signalling Glyco_hydro_2_C PF02836.17 ELR19962.1 - 0.098 11.8 0.0 0.16 11.0 0.0 1.3 1 0 0 1 1 1 0 Glycosyl hydrolases family 2, TIM barrel domain Pkinase PF00069.25 ELR19963.1 - 1e-14 54.6 0.0 8.5e-08 31.9 0.0 3.0 3 0 0 3 3 3 2 Protein kinase domain Arrestin_C PF02752.22 ELR19963.1 - 7.6e-05 23.2 0.0 0.00021 21.7 0.0 1.7 2 0 0 2 2 2 1 Arrestin (or S-antigen), C-terminal domain SPRY PF00622.28 ELR19963.1 - 0.0019 18.3 0.0 0.0053 16.9 0.0 1.7 1 0 0 1 1 1 1 SPRY domain F-box-like PF12937.7 ELR19963.1 - 0.027 14.4 0.0 0.064 13.2 0.0 1.6 1 0 0 1 1 1 0 F-box-like Nsp1_C PF05064.13 ELR19964.1 - 8.8e-28 96.4 4.2 8.8e-28 96.4 4.2 2.5 2 1 0 2 2 2 1 Nsp1-like C-terminal region DUF573 PF04504.14 ELR19964.1 - 0.11 13.2 0.3 0.35 11.6 0.3 1.8 1 0 0 1 1 1 0 Protein of unknown function, DUF573 V-SNARE PF05008.15 ELR19964.1 - 0.17 12.2 5.2 0.13 12.6 1.5 2.3 2 1 0 2 2 2 0 Vesicle transport v-SNARE protein N-terminus Vip3A_N PF12495.8 ELR19964.1 - 0.94 9.3 3.4 1.8 8.4 3.3 1.5 1 1 0 1 1 1 0 Vegetative insecticide protein 3A N terminal DUF1664 PF07889.12 ELR19964.1 - 1.5 8.8 5.7 2.2 8.3 0.6 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) WXG100 PF06013.12 ELR19964.1 - 1.6 9.0 8.7 1.8 8.9 4.0 3.2 2 1 0 2 2 2 0 Proteins of 100 residues with WXG DASH_Dad2 PF08654.10 ELR19964.1 - 1.6 9.2 6.2 3.7 8.0 0.2 3.3 2 1 1 3 3 3 0 DASH complex subunit Dad2 DUF489 PF04356.12 ELR19964.1 - 2 8.4 5.3 2.3 8.2 0.8 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF489) Prefoldin PF02996.17 ELR19964.1 - 2.5 8.0 6.6 1.7 8.6 0.8 2.9 3 0 0 3 3 3 0 Prefoldin subunit APG6_N PF17675.1 ELR19964.1 - 2.7 8.5 12.5 2.3 8.8 1.5 2.3 1 1 0 2 2 2 0 Apg6 coiled-coil region Snapin_Pallidin PF14712.6 ELR19964.1 - 3.1 8.3 12.0 1.9 8.9 1.2 3.1 2 1 0 3 3 3 0 Snapin/Pallidin Laminin_II PF06009.12 ELR19964.1 - 3.4 7.7 12.4 0.36 10.8 3.1 2.5 1 1 0 2 2 2 0 Laminin Domain II CLZ PF16526.5 ELR19964.1 - 3.6 8.0 6.0 43 4.6 0.4 3.2 3 0 0 3 3 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels FlaC_arch PF05377.11 ELR19964.1 - 8.8 6.8 6.2 26 5.3 2.4 3.0 3 0 0 3 3 3 0 Flagella accessory protein C (FlaC) WH2 PF02205.20 ELR19965.1 - 2.4e-05 24.0 0.3 0.00012 21.7 0.0 2.4 2 0 0 2 2 2 1 WH2 motif Med9 PF07544.13 ELR19965.1 - 0.011 15.8 7.7 0.073 13.2 7.7 2.5 1 0 0 1 1 1 0 RNA polymerase II transcription mediator complex subunit 9 Pex26 PF07163.12 ELR19965.1 - 3.9 6.7 14.2 3.4 6.9 4.5 2.6 2 0 0 2 2 2 0 Pex26 protein SR-25 PF10500.9 ELR19965.1 - 4.1 6.9 74.0 0.24 11.0 16.6 3.6 3 0 0 3 3 3 0 Nuclear RNA-splicing-associated protein LMBR1 PF04791.16 ELR19965.1 - 5.6 5.8 9.1 0.23 10.3 3.5 1.5 2 0 0 2 2 2 0 LMBR1-like membrane protein Amidohydro_1 PF01979.20 ELR19967.1 - 4.6e-45 154.4 0.0 4.5e-33 115.0 0.0 2.1 2 0 0 2 2 2 2 Amidohydrolase family Amidohydro_3 PF07969.11 ELR19967.1 - 1.6e-12 47.6 0.1 8.7e-08 32.1 0.0 3.0 2 1 0 2 2 2 2 Amidohydrolase family MBOAT PF03062.19 ELR19969.1 - 4.9e-18 65.6 19.2 4.9e-18 65.6 19.2 2.9 3 1 0 3 3 3 1 MBOAT, membrane-bound O-acyltransferase family CENP-B_dimeris PF09026.10 ELR19969.1 - 0.3 11.5 7.8 1.4 9.4 0.1 2.4 2 0 0 2 2 2 0 Centromere protein B dimerisation domain Methyltransf_16 PF10294.9 ELR19970.1 - 2e-17 63.5 0.1 2.7e-17 63.0 0.1 1.1 1 0 0 1 1 1 1 Lysine methyltransferase PrmA PF06325.13 ELR19970.1 - 2e-07 30.7 0.1 2.9e-07 30.2 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_23 PF13489.6 ELR19970.1 - 3.2e-07 30.4 0.0 4.6e-07 29.8 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ELR19970.1 - 0.0001 22.9 0.1 0.0002 22.1 0.1 1.5 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 ELR19970.1 - 0.00015 21.3 0.3 0.00095 18.7 0.3 1.9 1 1 0 1 1 1 1 Methyltransferase small domain Methyltransf_31 PF13847.6 ELR19970.1 - 0.0027 17.5 0.1 0.0058 16.4 0.1 1.6 1 1 0 1 1 1 1 Methyltransferase domain DREV PF05219.12 ELR19970.1 - 0.12 11.5 0.8 1.4 7.9 0.8 2.5 1 1 0 1 1 1 0 DREV methyltransferase BTB_2 PF02214.22 ELR19971.1 - 2.1e-13 50.4 0.0 4.8e-13 49.3 0.0 1.6 1 0 0 1 1 1 1 BTB/POZ domain Pentapeptide_4 PF13599.6 ELR19971.1 - 0.019 15.1 0.9 0.034 14.3 0.9 1.3 1 0 0 1 1 1 0 Pentapeptide repeats (9 copies) RFX_DNA_binding PF02257.15 ELR19975.1 - 1.8e-11 44.5 0.0 5e-11 43.1 0.0 1.8 1 0 0 1 1 1 1 RFX DNA-binding domain zinc_ribbon_2 PF13240.6 ELR19975.1 - 0.16 11.7 0.3 0.16 11.7 0.3 1.9 2 0 0 2 2 2 0 zinc-ribbon domain Pkinase PF00069.25 ELR19976.1 - 2.5e-63 213.9 0.0 5.6e-63 212.8 0.0 1.6 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR19976.1 - 1.9e-25 89.6 0.0 4.5e-24 85.1 0.0 2.3 1 1 0 1 1 1 1 Protein tyrosine kinase zf_C2HC_14 PF18574.1 ELR19976.1 - 6.1e-05 22.7 0.1 0.00013 21.7 0.1 1.4 1 0 0 1 1 1 1 C2HC Zing finger domain Kinase-like PF14531.6 ELR19976.1 - 7.5e-05 22.2 0.2 0.00047 19.6 0.0 2.2 3 0 0 3 3 3 1 Kinase-like Haspin_kinase PF12330.8 ELR19976.1 - 0.00074 18.6 0.0 0.0015 17.5 0.0 1.4 1 0 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 ELR19976.1 - 0.001 18.5 0.0 0.0023 17.3 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 ELR19976.1 - 0.0021 16.9 2.6 0.0057 15.5 0.0 2.4 2 0 0 2 2 2 1 Fungal protein kinase RIO1 PF01163.22 ELR19976.1 - 0.014 15.0 0.0 0.055 13.1 0.0 2.0 1 0 0 1 1 1 0 RIO1 family APH PF01636.23 ELR19976.1 - 0.015 15.2 0.1 0.015 15.2 0.1 3.3 2 1 1 3 3 3 0 Phosphotransferase enzyme family GlutR_N PF05201.15 ELR19976.1 - 0.051 13.3 0.1 0.14 11.9 0.1 1.7 1 0 0 1 1 1 0 Glutamyl-tRNAGlu reductase, N-terminal domain PTH2 PF01981.16 ELR19977.1 - 7.1e-45 152.1 0.1 1e-44 151.6 0.1 1.2 1 0 0 1 1 1 1 Peptidyl-tRNA hydrolase PTH2 BUD22 PF09073.10 ELR19977.1 - 3.6e-05 23.3 7.2 4.2e-05 23.1 7.2 1.1 1 0 0 1 1 1 1 BUD22 Mpp10 PF04006.12 ELR19977.1 - 0.00033 19.3 7.5 0.00038 19.1 7.5 1.1 1 0 0 1 1 1 1 Mpp10 protein SpoIIIAH PF12685.7 ELR19977.1 - 0.001 18.9 0.2 0.0013 18.6 0.2 1.1 1 0 0 1 1 1 1 SpoIIIAH-like protein Sigma70_ner PF04546.13 ELR19977.1 - 0.001 19.0 3.6 0.0013 18.7 3.6 1.2 1 0 0 1 1 1 1 Sigma-70, non-essential region Myc_N PF01056.18 ELR19977.1 - 0.0022 18.0 2.3 0.0028 17.6 2.3 1.2 1 0 0 1 1 1 1 Myc amino-terminal region DNA_pol_phi PF04931.13 ELR19977.1 - 0.0075 14.4 19.2 0.0088 14.2 19.2 1.1 1 0 0 1 1 1 1 DNA polymerase phi Nop14 PF04147.12 ELR19977.1 - 0.014 13.7 12.4 0.016 13.5 12.4 1.1 1 0 0 1 1 1 0 Nop14-like family SDA1 PF05285.12 ELR19977.1 - 0.018 14.5 11.8 0.022 14.2 11.8 1.2 1 0 0 1 1 1 0 SDA1 TRAP_alpha PF03896.16 ELR19977.1 - 0.025 13.8 5.0 0.033 13.4 5.0 1.2 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit DUF4834 PF16118.5 ELR19977.1 - 0.04 14.9 0.0 0.082 13.9 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) CDC27 PF09507.10 ELR19977.1 - 0.048 13.0 9.1 0.058 12.8 9.1 1.1 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 SID-1_RNA_chan PF13965.6 ELR19977.1 - 0.05 12.0 0.0 0.063 11.7 0.0 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Astro_capsid_p PF12226.8 ELR19977.1 - 0.054 12.6 11.6 0.076 12.2 11.6 1.1 1 0 0 1 1 1 0 Turkey astrovirus capsid protein Nop53 PF07767.11 ELR19977.1 - 0.064 12.6 9.6 0.082 12.3 9.6 1.2 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) RNA_pol_Rpc4 PF05132.14 ELR19977.1 - 0.074 13.5 0.7 0.11 12.9 0.3 1.5 2 0 0 2 2 2 0 RNA polymerase III RPC4 CPSF100_C PF13299.6 ELR19977.1 - 0.079 13.1 2.8 0.09 13.0 2.2 1.4 1 1 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal DUF913 PF06025.12 ELR19977.1 - 0.089 11.8 0.3 0.11 11.5 0.3 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) SAPS PF04499.15 ELR19977.1 - 0.1 11.4 0.4 0.12 11.2 0.4 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein IFT57 PF10498.9 ELR19977.1 - 0.12 11.3 4.3 0.16 10.9 4.3 1.1 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 Pox_Ag35 PF03286.14 ELR19977.1 - 0.13 12.0 11.5 0.22 11.3 11.5 1.3 1 0 0 1 1 1 0 Pox virus Ag35 surface protein Zip PF02535.22 ELR19977.1 - 0.17 11.1 0.1 0.21 10.8 0.1 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter NOA36 PF06524.12 ELR19977.1 - 0.21 10.9 18.6 0.34 10.2 18.6 1.3 1 0 0 1 1 1 0 NOA36 protein CDC45 PF02724.14 ELR19977.1 - 0.28 9.4 14.5 0.34 9.2 14.5 1.1 1 0 0 1 1 1 0 CDC45-like protein Afi1 PF07792.12 ELR19977.1 - 0.33 11.4 8.8 0.59 10.6 8.8 1.3 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking NPR3 PF03666.13 ELR19977.1 - 0.8 8.4 4.3 0.94 8.2 4.3 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 DUF2457 PF10446.9 ELR19977.1 - 1.4 8.0 24.6 2 7.5 24.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) TFIIA PF03153.13 ELR19977.1 - 2 8.3 18.2 3 7.7 18.2 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit RXT2_N PF08595.11 ELR19977.1 - 3 7.8 12.4 5.3 7.0 12.4 1.4 1 0 0 1 1 1 0 RXT2-like, N-terminal Cytomega_UL84 PF06284.11 ELR19977.1 - 3.9 5.8 9.2 5.3 5.4 9.2 1.2 1 0 0 1 1 1 0 Cytomegalovirus UL84 protein Sporozoite_P67 PF05642.11 ELR19977.1 - 4.7 5.2 8.3 5.8 4.9 8.3 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen RFX_DNA_binding PF02257.15 ELR19978.1 - 1.1e-14 54.8 0.0 2.4e-14 53.7 0.0 1.6 1 0 0 1 1 1 1 RFX DNA-binding domain C2-set_2 PF08205.12 ELR19978.1 - 0.11 12.6 0.0 0.23 11.5 0.0 1.5 1 0 0 1 1 1 0 CD80-like C2-set immunoglobulin domain Glyco_transf_20 PF00982.21 ELR19980.1 - 2.8e-130 435.2 0.0 4e-130 434.7 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 20 Trehalose_PPase PF02358.16 ELR19980.1 - 7.2e-63 211.8 0.0 1.1e-62 211.3 0.0 1.2 1 0 0 1 1 1 1 Trehalose-phosphatase Glyco_trans_1_4 PF13692.6 ELR19980.1 - 0.0072 16.8 0.1 0.023 15.1 0.1 1.8 1 0 0 1 1 1 1 Glycosyl transferases group 1 Hydrolase_3 PF08282.12 ELR19980.1 - 0.039 13.7 0.0 0.38 10.4 0.0 2.1 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase EF-hand_1 PF00036.32 ELR19981.1 - 4.7e-05 22.6 0.0 0.27 10.9 0.0 2.5 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 ELR19981.1 - 9.6e-05 22.8 0.0 0.0002 21.8 0.0 1.5 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 ELR19981.1 - 0.00096 18.9 0.0 0.19 11.8 0.0 2.5 2 0 0 2 2 2 2 EF-hand domain Methyltransf_16 PF10294.9 ELR19982.1 - 6.6e-19 68.3 0.0 3.4e-18 66.0 0.0 1.8 2 0 0 2 2 2 1 Lysine methyltransferase PrmA PF06325.13 ELR19982.1 - 2.7e-06 27.0 0.1 3.9e-06 26.5 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_23 PF13489.6 ELR19982.1 - 7.1e-06 25.9 0.0 1e-05 25.5 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 ELR19982.1 - 1.7e-05 24.5 0.1 0.00016 21.3 0.1 2.0 1 1 0 1 1 1 1 Methyltransferase small domain Methyltransf_12 PF08242.12 ELR19982.1 - 0.00014 22.5 0.1 0.00023 21.8 0.1 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ELR19982.1 - 0.00033 21.3 0.0 0.00087 19.9 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ELR19982.1 - 0.0016 19.1 0.0 0.0033 18.0 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain NNMT_PNMT_TEMT PF01234.17 ELR19982.1 - 0.031 13.4 0.0 0.058 12.6 0.0 1.4 1 0 0 1 1 1 0 NNMT/PNMT/TEMT family Methyltransf_2 PF00891.18 ELR19982.1 - 0.052 12.8 0.1 0.087 12.1 0.1 1.5 1 1 0 1 1 1 0 O-methyltransferase domain Methyltransf_31 PF13847.6 ELR19982.1 - 0.081 12.7 0.1 0.21 11.4 0.1 1.7 1 1 0 1 1 1 0 Methyltransferase domain DREV PF05219.12 ELR19982.1 - 0.085 11.9 0.7 1.5 7.8 0.1 2.3 1 1 1 2 2 2 0 DREV methyltransferase DUF3577 PF12101.8 ELR19982.1 - 0.11 12.3 0.0 0.2 11.4 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3577) G-alpha PF00503.20 ELR19983.1 - 6.7e-110 367.6 8.7 8e-110 367.3 8.7 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 ELR19983.1 - 3.5e-15 55.9 1.8 7.2e-11 41.8 0.2 2.6 2 1 0 2 2 2 2 ADP-ribosylation factor family Gtr1_RagA PF04670.12 ELR19983.1 - 1.4e-05 24.6 2.9 0.00027 20.4 0.2 2.4 2 0 0 2 2 2 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 ELR19983.1 - 0.0012 18.5 0.1 0.023 14.3 0.1 2.5 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain Sigma54_activat PF00158.26 ELR19983.1 - 0.0047 16.7 0.3 0.014 15.1 0.1 1.8 2 0 0 2 2 2 1 Sigma-54 interaction domain Roc PF08477.13 ELR19983.1 - 0.043 14.0 0.2 15 5.8 0.0 2.7 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase RPM2 PF08579.11 ELR19983.1 - 0.064 13.7 0.5 0.34 11.3 0.1 2.1 1 1 1 2 2 2 0 Mitochondrial ribonuclease P subunit (RPM2) TniB PF05621.11 ELR19983.1 - 0.11 11.9 0.0 0.21 11.0 0.0 1.4 1 0 0 1 1 1 0 Bacterial TniB protein Pyridoxal_deC PF00282.19 ELR19984.1 - 1.8e-15 56.6 0.0 5.2e-14 51.7 0.0 2.3 1 1 1 2 2 2 1 Pyridoxal-dependent decarboxylase conserved domain Aminotran_5 PF00266.19 ELR19984.1 - 1.2e-05 24.5 0.0 4.1e-05 22.7 0.0 1.8 1 1 0 1 1 1 1 Aminotransferase class-V DegT_DnrJ_EryC1 PF01041.17 ELR19984.1 - 0.015 14.7 0.1 0.023 14.0 0.1 1.2 1 0 0 1 1 1 0 DegT/DnrJ/EryC1/StrS aminotransferase family Cys_Met_Meta_PP PF01053.20 ELR19984.1 - 0.021 13.4 0.0 0.03 12.8 0.0 1.2 1 0 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme Na_Ca_ex PF01699.24 ELR19985.1 - 6.9e-22 78.0 28.1 2.2e-12 47.2 12.1 2.1 2 0 0 2 2 2 2 Sodium/calcium exchanger protein Wzy_C PF04932.15 ELR19985.1 - 0.29 10.8 5.6 0.057 13.1 0.9 2.2 2 1 0 2 2 2 0 O-Antigen ligase DUF4131 PF13567.6 ELR19985.1 - 1.9 8.1 10.2 2.4 7.8 2.4 3.3 2 2 1 3 3 3 0 Domain of unknown function (DUF4131) TPR_1 PF00515.28 ELR19986.1 - 3.9e-23 80.3 5.8 3.3e-07 29.8 0.3 4.0 3 1 0 3 3 3 3 Tetratricopeptide repeat TPR_11 PF13414.6 ELR19986.1 - 1.2e-17 63.3 7.0 3.4e-07 29.8 2.3 3.6 1 1 2 3 3 3 3 TPR repeat TPR_2 PF07719.17 ELR19986.1 - 8.5e-17 59.9 4.5 2.2e-05 24.2 0.2 4.1 3 1 0 3 3 3 3 Tetratricopeptide repeat TPR_8 PF13181.6 ELR19986.1 - 5.1e-14 51.2 2.5 0.00071 19.6 0.1 4.2 4 1 0 4 4 3 3 Tetratricopeptide repeat SGTA_dimer PF16546.5 ELR19986.1 - 2.9e-12 46.2 0.0 9.5e-12 44.5 0.0 1.9 2 0 0 2 2 2 1 Homodimerisation domain of SGTA TPR_17 PF13431.6 ELR19986.1 - 8.3e-12 44.6 4.7 0.00017 21.7 1.4 4.3 4 0 0 4 4 3 2 Tetratricopeptide repeat TPR_14 PF13428.6 ELR19986.1 - 4.2e-11 42.7 0.1 0.00017 22.2 0.0 3.7 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_16 PF13432.6 ELR19986.1 - 3.4e-09 37.2 0.1 1.4e-05 25.6 0.2 2.7 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_19 PF14559.6 ELR19986.1 - 2.9e-08 34.1 2.1 0.027 15.0 0.0 3.8 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.6 ELR19986.1 - 1.5e-06 28.4 3.4 0.0059 16.9 0.4 3.3 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_7 PF13176.6 ELR19986.1 - 4.4e-05 23.2 0.1 4.9 7.4 0.1 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_10 PF13374.6 ELR19986.1 - 8.3e-05 22.3 2.6 0.71 9.8 0.0 4.3 4 0 0 4 4 4 1 Tetratricopeptide repeat ANAPC3 PF12895.7 ELR19986.1 - 0.00017 21.8 0.7 0.0004 20.5 0.7 1.6 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 SGT1 PF07093.11 ELR19986.1 - 0.0004 19.0 0.0 0.00063 18.3 0.0 1.2 1 0 0 1 1 1 1 SGT1 protein TPR_3 PF07720.12 ELR19986.1 - 0.0023 17.9 0.0 0.035 14.1 0.0 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_15 PF13429.6 ELR19986.1 - 0.0066 15.7 0.1 0.95 8.6 0.0 2.3 1 1 1 2 2 2 2 Tetratricopeptide repeat STI1 PF17830.1 ELR19986.1 - 0.019 14.9 10.7 0.019 14.9 10.7 2.9 1 1 1 2 2 2 0 STI1 domain TPR_6 PF13174.6 ELR19986.1 - 0.026 15.1 7.1 2.5 8.9 0.1 3.8 6 0 0 6 6 2 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 ELR19986.1 - 0.064 13.3 1.0 4.5 7.4 0.0 2.8 2 0 0 2 2 2 0 Fis1 C-terminal tetratricopeptide repeat GerD PF17898.1 ELR19986.1 - 1.4 8.9 5.8 25 4.8 3.2 2.8 2 1 0 2 2 2 0 Spore germination GerD central core domain OGG_N PF07934.12 ELR19987.1 - 5.4e-20 71.7 0.0 1.3e-19 70.4 0.0 1.7 1 0 0 1 1 1 1 8-oxoguanine DNA glycosylase, N-terminal domain HhH-GPD PF00730.25 ELR19987.1 - 5e-17 62.3 0.0 1e-16 61.4 0.0 1.5 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein HHH PF00633.23 ELR19987.1 - 0.024 14.5 0.0 0.13 12.2 0.0 2.3 2 0 0 2 2 2 0 Helix-hairpin-helix motif DUF966 PF06136.13 ELR19987.1 - 0.025 14.3 4.7 0.035 13.8 4.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF966) Sporozoite_P67 PF05642.11 ELR19987.1 - 0.64 8.0 5.3 0.93 7.5 5.3 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen CAML PF14963.6 ELR19987.1 - 4.2 7.4 8.5 7.8 6.5 8.5 1.4 1 0 0 1 1 1 0 Calcium signal-modulating cyclophilin ligand DUF747 PF05346.11 ELR19988.1 - 7.8e-56 189.9 6.1 1.2e-55 189.2 6.1 1.3 1 1 0 1 1 1 1 Eukaryotic membrane protein family DUF747 PF05346.11 ELR19989.1 - 2.7e-27 96.1 0.7 3.8e-27 95.6 0.7 1.2 1 0 0 1 1 1 1 Eukaryotic membrane protein family RasGEF PF00617.19 ELR19990.1 - 1.2e-29 103.8 1.3 2.3e-29 102.9 1.3 1.5 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 ELR19990.1 - 4.6e-25 87.9 0.1 1.9e-24 85.9 0.1 2.2 1 0 0 1 1 1 1 RasGEF N-terminal motif F-box-like PF12937.7 ELR19990.1 - 2.6e-11 43.2 0.2 7.1e-11 41.8 0.2 1.8 1 0 0 1 1 1 1 F-box-like Evr1_Alr PF04777.13 ELR19990.1 - 0.00017 22.0 0.0 0.00049 20.5 0.0 1.8 1 0 0 1 1 1 1 Erv1 / Alr family F-box PF00646.33 ELR19990.1 - 0.058 13.3 1.4 0.26 11.2 1.4 2.2 1 1 0 1 1 1 0 F-box domain HEAT_2 PF13646.6 ELR19991.1 - 4.3e-38 129.6 8.2 2e-14 53.7 0.3 4.0 2 2 3 5 5 5 4 HEAT repeats HEAT_PBS PF03130.16 ELR19991.1 - 4.1e-27 92.1 5.2 0.00023 21.5 0.1 6.6 6 0 0 6 6 6 6 PBS lyase HEAT-like repeat HEAT PF02985.22 ELR19991.1 - 2.8e-16 58.2 0.7 0.007 16.5 0.0 6.5 7 0 0 7 7 7 5 HEAT repeat HEAT_EZ PF13513.6 ELR19991.1 - 9.3e-09 35.6 6.3 0.15 12.6 0.0 5.7 6 1 0 6 6 6 2 HEAT-like repeat Arm PF00514.23 ELR19991.1 - 0.00032 20.6 0.3 6.8 6.9 0.0 3.6 2 1 1 3 3 3 2 Armadillo/beta-catenin-like repeat TAF6_C PF07571.13 ELR19991.1 - 0.014 15.7 0.2 9.8 6.6 0.0 3.8 2 2 2 4 4 4 0 TAF6 C-terminal HEAT repeat domain Cnd1 PF12717.7 ELR19991.1 - 0.13 12.2 0.0 4.2 7.4 0.0 2.9 2 2 1 3 3 3 0 non-SMC mitotic condensation complex subunit 1 Exo_endo_phos PF03372.23 ELR19992.1 - 0.004 16.7 0.0 0.0054 16.3 0.0 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Pkinase_Tyr PF07714.17 ELR19993.1 - 4.3e-49 167.1 0.0 8.8e-49 166.1 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ELR19993.1 - 2.2e-45 155.1 0.0 3.9e-45 154.3 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Kinase-like PF14531.6 ELR19993.1 - 1e-05 25.0 0.0 1.6e-05 24.4 0.0 1.2 1 0 0 1 1 1 1 Kinase-like OTU PF02338.19 ELR19993.1 - 0.0018 18.8 0.0 0.0053 17.2 0.0 1.8 2 0 0 2 2 2 1 OTU-like cysteine protease APH PF01636.23 ELR19993.1 - 0.0062 16.5 0.4 0.054 13.4 0.2 2.2 1 1 1 2 2 2 1 Phosphotransferase enzyme family GlutR_N PF05201.15 ELR19993.1 - 0.01 15.6 0.2 0.083 12.6 0.2 2.2 2 0 0 2 2 2 0 Glutamyl-tRNAGlu reductase, N-terminal domain Cbl_N2 PF02761.14 ELR19993.1 - 0.015 16.0 0.1 0.032 14.9 0.1 1.5 1 0 0 1 1 1 0 CBL proto-oncogene N-terminus, EF hand-like domain Kdo PF06293.14 ELR19993.1 - 0.1 11.9 0.8 0.23 10.8 0.8 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family rRNA_processing PF08524.11 ELR19994.1 - 2.9e-06 27.4 37.7 2.9e-06 27.4 37.7 3.1 2 1 1 3 3 3 1 rRNA processing Orf78 PF06024.12 ELR19994.1 - 0.1 12.9 0.0 0.1 12.9 0.0 3.9 2 1 0 2 2 2 0 Orf78 (ac78) DUF4834 PF16118.5 ELR19994.1 - 0.17 12.9 0.0 0.17 12.9 0.0 3.5 1 1 1 2 2 2 0 Domain of unknown function (DUF4834) DUF4446 PF14584.6 ELR19994.1 - 0.74 9.8 0.0 0.74 9.8 0.0 3.1 2 1 1 3 3 3 0 Protein of unknown function (DUF4446) RskA PF10099.9 ELR19994.1 - 5.9 7.1 9.6 8.7 6.6 6.8 2.4 1 1 1 2 2 2 0 Anti-sigma-K factor rskA SLC35F PF06027.12 ELR19995.1 - 2.8e-26 92.7 9.6 3.2e-26 92.6 9.6 1.0 1 0 0 1 1 1 1 Solute carrier family 35 MtN3_slv PF03083.16 ELR19995.1 - 0.0094 16.0 1.7 0.016 15.2 1.7 1.6 1 1 0 1 1 1 1 Sugar efflux transporter for intercellular exchange SLC35F PF06027.12 ELR19998.1 - 4e-14 52.8 0.1 4.8e-14 52.6 0.1 1.0 1 0 0 1 1 1 1 Solute carrier family 35 Voldacs PF03517.13 ELR19999.1 - 1.9e-15 57.2 0.1 3.8e-08 33.5 0.0 2.5 1 1 1 2 2 2 2 Regulator of volume decrease after cellular swelling PRKCSH_1 PF13015.6 ELR19999.1 - 0.0054 16.4 0.0 0.0093 15.7 0.0 1.3 1 0 0 1 1 1 1 Glucosidase II beta subunit-like protein LRR_4 PF12799.7 ELR20001.1 - 1.5e-26 92.0 14.8 0.0042 17.5 0.1 11.0 6 2 6 13 13 13 9 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 ELR20001.1 - 2.6e-21 73.8 37.8 0.0072 16.3 0.0 17.0 19 0 0 19 19 19 5 Leucine Rich repeat LRR_8 PF13855.6 ELR20001.1 - 6.1e-10 38.7 14.6 0.028 14.2 0.5 9.5 7 4 1 9 9 9 3 Leucine rich repeat LRR_1 PF00560.33 ELR20001.1 - 5.2e-07 29.3 25.1 31 5.6 0.1 13.1 11 4 0 11 11 11 0 Leucine Rich Repeat Preseq_ALAS PF09029.10 ELR20001.1 - 7.5e-05 23.2 32.0 1 9.8 2.4 7.5 4 2 4 8 8 8 5 5-aminolevulinate synthase presequence DUF1699 PF08004.11 ELR20001.1 - 0.0015 18.2 6.6 31 4.3 0.0 8.1 5 2 7 12 12 12 0 Protein of unknown function (DUF1699) DUF3248 PF11609.8 ELR20001.1 - 0.048 13.6 0.1 4.3 7.3 0.0 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF3248) DUF3726 PF12525.8 ELR20001.1 - 0.05 13.7 0.0 3.1 8.0 0.0 3.4 4 1 0 4 4 4 0 Protein of unknown function (DUF3726) MiAMP1 PF09117.10 ELR20001.1 - 0.9 9.8 6.8 3.4 8.0 0.0 4.7 4 2 2 6 6 6 0 MiAMP1 CLU PF13236.6 ELR20002.1 - 2.1e-61 207.6 0.0 4e-61 206.6 0.0 1.5 1 0 0 1 1 1 1 Clustered mitochondria eIF3_p135 PF12807.7 ELR20002.1 - 3.2e-07 30.5 0.1 6.7e-07 29.5 0.1 1.4 1 0 0 1 1 1 1 Translation initiation factor eIF3 subunit 135 TPR_11 PF13414.6 ELR20002.1 - 0.03 14.0 0.4 0.12 12.1 0.4 2.1 1 0 0 1 1 1 0 TPR repeat FAT PF02259.23 ELR20002.1 - 0.065 12.4 0.1 0.12 11.6 0.1 1.4 1 0 0 1 1 1 0 FAT domain RhoGAP PF00620.27 ELR20003.1 - 3.7e-22 78.8 0.1 1.1e-21 77.2 0.0 1.9 2 0 0 2 2 2 1 RhoGAP domain LIM PF00412.22 ELR20003.1 - 1.2e-14 54.3 8.0 1.3e-11 44.6 3.5 2.7 2 0 0 2 2 2 2 LIM domain SAM_1 PF00536.30 ELR20004.1 - 9.4e-14 51.6 0.0 2.7e-13 50.2 0.0 1.8 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 ELR20004.1 - 6.7e-13 48.5 0.0 1.6e-12 47.3 0.0 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) HD PF01966.22 ELR20004.1 - 3e-12 46.8 0.1 5.9e-12 45.9 0.1 1.5 1 0 0 1 1 1 1 HD domain DUF4449 PF14613.6 ELR20005.1 - 3.4e-05 24.0 0.0 3.4e-05 24.0 0.0 3.4 4 0 0 4 4 4 1 Protein of unknown function (DUF4449) CorA PF01544.18 ELR20005.1 - 0.0043 16.4 8.6 0.022 14.1 2.1 2.4 2 0 0 2 2 2 2 CorA-like Mg2+ transporter protein TBCA PF02970.16 ELR20005.1 - 0.0083 16.4 0.3 0.0083 16.4 0.3 3.3 3 0 0 3 3 3 1 Tubulin binding cofactor A Cbl_N PF02262.16 ELR20005.1 - 0.089 12.8 0.1 0.86 9.6 0.0 2.6 2 1 0 2 2 2 0 CBL proto-oncogene N-terminal domain 1 Baculo_p24 PF05073.12 ELR20005.1 - 0.11 12.2 3.6 15 5.3 1.1 3.4 3 0 0 3 3 3 0 Baculovirus P24 capsid protein Cauli_AT PF03233.13 ELR20005.1 - 0.41 10.6 2.8 0.46 10.4 0.7 2.2 2 0 0 2 2 2 0 Aphid transmission protein DUF883 PF05957.13 ELR20005.1 - 0.8 10.4 29.2 12 6.6 5.3 5.0 4 1 1 5 5 5 0 Bacterial protein of unknown function (DUF883) XhlA PF10779.9 ELR20005.1 - 6.4 7.1 6.8 2 8.7 2.4 2.5 2 0 0 2 2 2 0 Haemolysin XhlA V-ATPase_G_2 PF16999.5 ELR20005.1 - 9.5 6.7 27.7 0.037 14.4 13.0 3.3 3 0 0 3 3 3 0 Vacuolar (H+)-ATPase G subunit Adaptin_N PF01602.20 ELR20006.1 - 8e-82 275.5 10.0 1.6e-81 274.5 10.0 1.4 1 1 0 1 1 1 1 Adaptin N terminal region Coatomer_b_Cpla PF14806.6 ELR20006.1 - 4.1e-58 194.9 0.0 1.3e-57 193.3 0.0 1.9 1 0 0 1 1 1 1 Coatomer beta subunit appendage platform Coatamer_beta_C PF07718.12 ELR20006.1 - 2.3e-41 141.0 0.0 2.1e-40 137.9 0.0 2.4 1 1 0 1 1 1 1 Coatomer beta C-terminal region HEAT_2 PF13646.6 ELR20006.1 - 1e-06 29.1 0.3 0.41 11.1 0.0 5.4 2 2 3 5 5 5 2 HEAT repeats Cnd1 PF12717.7 ELR20006.1 - 5.4e-06 26.5 3.9 0.00097 19.2 0.0 2.7 2 1 0 2 2 2 2 non-SMC mitotic condensation complex subunit 1 Coatomer_g_Cpla PF16381.5 ELR20006.1 - 0.00029 21.0 0.0 0.00071 19.7 0.0 1.7 1 0 0 1 1 1 1 Coatomer subunit gamma-1 C-terminal appendage platform Alpha_adaptinC2 PF02883.20 ELR20006.1 - 0.019 15.3 0.0 0.044 14.1 0.0 1.5 1 0 0 1 1 1 0 Adaptin C-terminal domain HEAT PF02985.22 ELR20006.1 - 0.03 14.6 0.1 7.7 7.1 0.0 4.5 4 0 0 4 4 4 0 HEAT repeat DUF5578 PF17741.1 ELR20006.1 - 0.034 13.5 4.4 4.2 6.7 0.0 2.9 2 1 2 4 4 4 0 Family of unknown function (DUF5578) Yae1_N PF09811.9 ELR20007.1 - 0.00035 20.2 3.6 0.0012 18.5 3.6 1.9 1 1 0 1 1 1 1 Essential protein Yae1, N terminal DUF3299 PF11736.8 ELR20007.1 - 0.063 13.3 0.1 0.1 12.6 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3299) IPPT PF01715.17 ELR20008.1 - 1.1e-43 149.7 0.0 4e-43 147.8 0.0 1.8 1 1 0 1 1 1 1 IPP transferase CAP PF00188.26 ELR20009.1 - 1.2e-10 42.4 1.3 1.7e-10 41.8 0.1 1.8 2 0 0 2 2 2 1 Cysteine-rich secretory protein family PH PF00169.29 ELR20011.1 - 6.1e-15 55.6 0.6 1.3e-06 28.8 0.0 2.9 2 0 0 2 2 2 2 PH domain Patatin PF01734.22 ELR20011.1 - 6.1e-10 39.6 0.4 4.1e-09 36.9 0.4 2.4 1 1 0 1 1 1 1 Patatin-like phospholipase PH_11 PF15413.6 ELR20011.1 - 0.00011 22.6 6.4 0.076 13.4 0.1 3.6 2 2 0 3 3 3 2 Pleckstrin homology domain PH_8 PF15409.6 ELR20011.1 - 0.028 14.7 3.9 1.4 9.3 0.2 3.2 3 0 0 3 3 3 0 Pleckstrin homology domain Sec20 PF03908.13 ELR20012.1 - 2.7e-06 27.2 1.1 4.1e-05 23.4 0.0 2.8 3 0 0 3 3 3 1 Sec20 Bac_GDH PF05088.12 ELR20012.1 - 0.024 12.1 0.2 0.029 11.9 0.2 1.0 1 0 0 1 1 1 0 Bacterial NAD-glutamate dehydrogenase FlgN PF05130.12 ELR20012.1 - 0.026 15.1 3.0 1.1 9.7 2.1 2.1 2 0 0 2 2 2 0 FlgN protein Nuc_rec_co-act PF08815.10 ELR20012.1 - 0.1 12.5 0.7 0.3 10.9 0.1 2.0 2 0 0 2 2 2 0 Nuclear receptor coactivator Ras PF00071.22 ELR20013.1 - 6.8e-31 107.1 0.4 1e-30 106.5 0.4 1.3 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR20013.1 - 7.2e-21 74.6 0.1 1.4e-20 73.7 0.0 1.5 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR20013.1 - 1.4e-07 31.1 0.2 3.3e-07 29.9 0.2 1.6 1 1 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 ELR20013.1 - 6.4e-05 22.4 0.8 0.00012 21.5 0.8 1.4 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 ELR20013.1 - 0.0023 18.0 0.0 0.0043 17.1 0.0 1.6 1 1 0 1 1 1 1 50S ribosome-binding GTPase G-alpha PF00503.20 ELR20013.1 - 0.003 16.8 3.5 0.51 9.4 0.1 3.0 2 1 1 3 3 3 1 G-protein alpha subunit GTP_EFTU PF00009.27 ELR20013.1 - 0.0031 17.1 0.3 0.039 13.5 0.1 2.1 1 1 0 2 2 2 1 Elongation factor Tu GTP binding domain CENP-M PF11111.8 ELR20013.1 - 0.0061 15.8 0.1 0.012 14.9 0.1 1.4 1 0 0 1 1 1 1 Centromere protein M (CENP-M) RsgA_GTPase PF03193.16 ELR20013.1 - 0.0091 15.9 0.3 1.1 9.1 0.1 2.2 2 0 0 2 2 2 1 RsgA GTPase SRPRB PF09439.10 ELR20013.1 - 0.045 13.2 0.1 0.091 12.2 0.0 1.4 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit FeoB_N PF02421.18 ELR20013.1 - 0.055 13.0 0.2 0.77 9.3 0.2 2.2 1 1 0 1 1 1 0 Ferrous iron transport protein B YdjC PF04794.12 ELR20013.1 - 0.075 13.0 0.0 0.11 12.5 0.0 1.2 1 0 0 1 1 1 0 YdjC-like protein AAA_7 PF12775.7 ELR20013.1 - 0.12 11.9 0.5 0.24 10.9 0.1 1.7 2 0 0 2 2 2 0 P-loop containing dynein motor region IPK PF03770.16 ELR20014.1 - 4e-29 101.9 0.0 1.6e-27 96.7 0.0 2.3 1 1 0 1 1 1 1 Inositol polyphosphate kinase CBS PF00571.28 ELR20015.1 - 3.7e-24 84.9 0.7 1.1e-06 29.0 0.0 4.4 4 0 0 4 4 4 4 CBS domain AAA_16 PF13191.6 ELR20016.1 - 6.6e-09 36.4 0.2 8.5e-08 32.8 0.0 2.3 2 1 0 2 2 2 1 AAA ATPase domain NB-ARC PF00931.22 ELR20016.1 - 0.00025 20.3 0.0 0.00042 19.6 0.0 1.2 1 0 0 1 1 1 1 NB-ARC domain ATPase_2 PF01637.18 ELR20016.1 - 0.0045 16.9 0.0 0.0077 16.2 0.0 1.3 1 0 0 1 1 1 1 ATPase domain predominantly from Archaea NACHT PF05729.12 ELR20016.1 - 0.011 15.7 0.0 2.7 7.9 0.0 2.3 2 0 0 2 2 2 0 NACHT domain AAA PF00004.29 ELR20016.1 - 0.041 14.3 0.0 0.083 13.3 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 ELR20016.1 - 0.051 13.3 0.0 0.13 12.0 0.0 1.7 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain KTI12 PF08433.10 ELR20016.1 - 0.072 12.5 0.0 0.12 11.8 0.0 1.3 1 0 0 1 1 1 0 Chromatin associated protein KTI12 AAA_33 PF13671.6 ELR20016.1 - 0.15 12.2 0.0 0.38 10.9 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 ELR20016.1 - 0.23 12.0 0.0 0.44 11.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain AlbA_2 PF04326.14 ELR20017.1 - 2.1e-19 70.0 0.0 4.4e-19 69.0 0.0 1.5 1 0 0 1 1 1 1 Putative DNA-binding domain NOA36 PF06524.12 ELR20017.1 - 1 8.7 4.6 2.1 7.6 4.6 1.5 1 0 0 1 1 1 0 NOA36 protein Nup35_RRM_2 PF14605.6 ELR20018.1 - 0.017 15.1 0.0 0.033 14.2 0.0 1.6 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif Zn-ribbon_8 PF09723.10 ELR20018.1 - 2.1 8.5 6.2 23 5.2 2.8 2.5 2 0 0 2 2 2 0 Zinc ribbon domain RVT_1 PF00078.27 ELR20019.1 - 4.1e-20 72.2 0.0 6.6e-20 71.6 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Period_C PF12114.8 ELR20020.1 - 0.026 14.1 0.9 0.026 14.1 0.9 2.0 2 0 0 2 2 2 0 Period protein 2/3C-terminal region UPF0004 PF00919.20 ELR20021.1 - 0.53 10.4 3.8 0.24 11.5 0.4 2.3 2 1 1 3 3 3 0 Uncharacterized protein family UPF0004 LAP1C PF05609.12 ELR20021.1 - 1.9 7.5 23.1 2.1 7.4 23.1 1.0 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) PSK PF06404.12 ELR20021.1 - 5.2 8.2 17.1 0.42 11.6 5.3 2.4 2 0 0 2 2 2 0 Phytosulfokine precursor protein (PSK) ATG2_CAD PF13329.6 ELR20022.1 - 0.11 12.2 0.0 0.19 11.4 0.0 1.4 1 0 0 1 1 1 0 Autophagy-related protein 2 CAD motif Neurensin PF14927.6 ELR20022.1 - 0.14 11.9 0.0 0.31 10.8 0.0 1.5 1 0 0 1 1 1 0 Neurensin M20_dimer PF07687.14 ELR20023.1 - 4.2e-12 46.0 0.0 7.2e-12 45.2 0.0 1.4 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M20 PF01546.28 ELR20023.1 - 2.3e-07 30.8 0.0 0.002 17.9 0.0 2.2 1 1 1 2 2 2 2 Peptidase family M20/M25/M40 Nuc_sug_transp PF04142.15 ELR20024.1 - 4.2e-31 108.3 15.0 6.4e-31 107.7 15.0 1.2 1 0 0 1 1 1 1 Nucleotide-sugar transporter PUNUT PF16913.5 ELR20024.1 - 0.0012 18.2 9.9 0.021 14.1 0.6 2.1 2 0 0 2 2 2 2 Purine nucleobase transmembrane transport IMD PF08397.11 ELR20025.1 - 2.8e-14 53.0 12.3 3.8e-14 52.6 12.3 1.1 1 0 0 1 1 1 1 IRSp53/MIM homology domain SH3_1 PF00018.28 ELR20025.1 - 2.2e-09 36.8 0.0 4.5e-09 35.8 0.0 1.6 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 ELR20025.1 - 2.6e-08 33.4 0.0 4.5e-08 32.7 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.6 ELR20025.1 - 7.7e-08 32.1 0.0 1.2e-07 31.4 0.0 1.3 1 0 0 1 1 1 1 Variant SH3 domain Arfaptin PF06456.13 ELR20025.1 - 0.00051 19.7 14.6 0.0025 17.4 12.6 2.7 2 1 0 2 2 2 1 Arfaptin-like domain ChpXY PF10216.9 ELR20025.1 - 0.018 14.2 0.2 0.035 13.2 0.1 1.4 1 1 0 1 1 1 0 CO2 hydration protein (ChpXY) SGS PF05002.15 ELR20025.1 - 0.083 13.0 0.1 0.083 13.0 0.1 2.7 2 1 1 3 3 3 0 SGS domain YkyA PF10368.9 ELR20025.1 - 0.12 12.1 17.2 1.9 8.1 8.4 3.4 3 1 0 3 3 3 0 Putative cell-wall binding lipoprotein Mt_ATP-synt_D PF05873.12 ELR20025.1 - 0.22 11.3 13.2 0.099 12.5 8.0 2.5 2 1 1 3 3 3 0 ATP synthase D chain, mitochondrial (ATP5H) Golgin_A5 PF09787.9 ELR20025.1 - 0.48 9.8 13.8 2.3 7.6 5.7 2.8 1 1 2 3 3 3 0 Golgin subfamily A member 5 DUF2937 PF11157.8 ELR20025.1 - 0.6 9.8 2.7 4.2 7.1 0.4 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF2937) DUF3584 PF12128.8 ELR20025.1 - 0.69 7.4 14.5 0.08 10.4 9.3 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF3584) zf-RING_2 PF13639.6 ELR20026.1 - 2.4e-09 37.4 17.4 3.6e-09 36.8 17.4 1.3 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 ELR20026.1 - 1.1e-05 25.2 17.1 1.7e-05 24.6 17.1 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 ELR20026.1 - 3.6e-05 23.5 15.1 5.3e-05 23.0 15.1 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 ELR20026.1 - 3.9e-05 23.9 15.4 9.5e-05 22.6 15.3 1.6 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 ELR20026.1 - 5.6e-05 22.9 18.1 9.2e-05 22.2 18.1 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ELR20026.1 - 0.0031 17.4 17.9 0.0069 16.3 17.9 1.6 1 1 0 1 1 1 1 zinc-RING finger domain Prok-RING_4 PF14447.6 ELR20026.1 - 0.0065 16.3 14.5 0.014 15.2 14.6 1.5 1 1 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.6 ELR20026.1 - 0.051 13.7 10.8 0.051 13.7 10.8 2.1 2 0 0 2 2 2 0 zinc finger of C3HC4-type, RING Apt1 PF10351.9 ELR20026.1 - 0.095 11.5 1.7 0.11 11.3 1.7 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain zf-RING_UBOX PF13445.6 ELR20026.1 - 0.13 12.3 11.5 0.13 12.3 10.0 1.8 1 1 1 2 2 2 0 RING-type zinc-finger V_ATPase_I PF01496.19 ELR20026.1 - 0.17 9.8 0.3 0.2 9.5 0.3 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family zf-RING_6 PF14835.6 ELR20026.1 - 0.3 11.0 9.9 0.53 10.2 9.9 1.3 1 0 0 1 1 1 0 zf-RING of BARD1-type protein Presenilin PF01080.17 ELR20026.1 - 0.55 8.9 5.7 0.71 8.6 5.7 1.1 1 0 0 1 1 1 0 Presenilin zf-ANAPC11 PF12861.7 ELR20026.1 - 0.59 10.2 10.0 1.5 8.9 10.0 1.6 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-P11 PF03854.14 ELR20026.1 - 1.5 8.5 11.7 2.9 7.6 11.7 1.6 1 1 0 1 1 1 0 P-11 zinc finger zf-RING_11 PF17123.5 ELR20026.1 - 6.6 6.6 16.5 12 5.7 16.5 1.5 1 0 0 1 1 1 0 RING-like zinc finger F-box-like PF12937.7 ELR20028.1 - 3.3e-09 36.5 0.6 1.2e-08 34.7 0.1 2.0 1 1 1 2 2 2 1 F-box-like F-box PF00646.33 ELR20028.1 - 0.0001 22.1 0.5 0.00016 21.4 0.1 1.6 2 0 0 2 2 2 1 F-box domain SRP19 PF01922.17 ELR20030.1 - 3.1e-30 105.0 0.1 3.7e-30 104.7 0.1 1.1 1 0 0 1 1 1 1 SRP19 protein Ribosomal_60s PF00428.19 ELR20030.1 - 0.017 15.7 0.1 0.09 13.4 0.1 2.0 1 1 0 1 1 1 0 60s Acidic ribosomal protein Sulfate_transp PF00916.20 ELR20031.1 - 7.4e-95 317.9 20.2 1e-94 317.5 20.2 1.1 1 0 0 1 1 1 1 Sulfate permease family STAS PF01740.21 ELR20031.1 - 5.6e-22 77.6 0.0 1.5e-21 76.2 0.0 1.8 2 0 0 2 2 2 1 STAS domain STAS_2 PF13466.6 ELR20031.1 - 0.0029 17.9 0.0 0.0081 16.5 0.0 1.8 1 0 0 1 1 1 1 STAS domain MFS_MOT1 PF16983.5 ELR20031.1 - 3.3 8.1 16.7 0.022 15.1 3.1 3.0 2 1 0 2 2 2 0 Molybdate transporter of MFS superfamily MitMem_reg PF13012.6 ELR20032.1 - 1.1e-29 103.1 0.1 1.7e-29 102.5 0.1 1.3 1 0 0 1 1 1 1 Maintenance of mitochondrial structure and function JAB PF01398.21 ELR20032.1 - 9.8e-19 67.5 0.0 1.8e-18 66.6 0.0 1.4 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease IU_nuc_hydro PF01156.19 ELR20033.1 - 2.1e-87 293.6 0.0 2.4e-87 293.3 0.0 1.0 1 0 0 1 1 1 1 Inosine-uridine preferring nucleoside hydrolase HTH_42 PF06224.12 ELR20033.1 - 0.049 13.2 0.2 0.072 12.6 0.2 1.2 1 0 0 1 1 1 0 Winged helix DNA-binding domain ABC2_membrane PF01061.24 ELR20034.1 - 1.4e-42 145.6 19.6 1.9e-42 145.1 19.6 1.2 1 0 0 1 1 1 1 ABC-2 type transporter ABC_tran PF00005.27 ELR20034.1 - 7.7e-30 104.2 0.0 1.2e-29 103.6 0.0 1.3 1 0 0 1 1 1 1 ABC transporter T2SSE PF00437.20 ELR20034.1 - 0.00017 20.8 0.8 0.0024 17.0 0.1 2.1 2 0 0 2 2 2 1 Type II/IV secretion system protein AAA_16 PF13191.6 ELR20034.1 - 0.00018 21.9 0.0 0.0003 21.2 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain RsgA_GTPase PF03193.16 ELR20034.1 - 0.00045 20.2 0.1 0.00084 19.3 0.1 1.4 1 0 0 1 1 1 1 RsgA GTPase AAA_21 PF13304.6 ELR20034.1 - 0.00074 19.4 0.0 0.51 10.1 0.0 2.5 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_25 PF13481.6 ELR20034.1 - 0.00086 18.9 0.0 0.0017 18.0 0.0 1.4 1 0 0 1 1 1 1 AAA domain ABC2_membrane_3 PF12698.7 ELR20034.1 - 0.0021 17.3 18.0 0.0021 17.3 18.0 2.0 1 1 1 2 2 2 1 ABC-2 family transporter protein AAA_30 PF13604.6 ELR20034.1 - 0.0034 17.1 0.0 0.0074 16.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 ELR20034.1 - 0.0068 17.0 0.0 0.015 15.8 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_23 PF13476.6 ELR20034.1 - 0.0086 16.6 0.0 0.017 15.6 0.0 1.4 1 0 0 1 1 1 1 AAA domain DUF87 PF01935.17 ELR20034.1 - 0.011 15.9 0.2 0.018 15.1 0.2 1.3 1 0 0 1 1 1 0 Helicase HerA, central domain AAA_28 PF13521.6 ELR20034.1 - 0.013 15.8 0.1 0.042 14.1 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_29 PF13555.6 ELR20034.1 - 0.018 14.8 0.0 0.045 13.5 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain cobW PF02492.19 ELR20034.1 - 0.019 14.6 0.1 0.054 13.1 0.2 1.7 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_22 PF13401.6 ELR20034.1 - 0.02 15.2 0.0 0.043 14.1 0.0 1.6 1 0 0 1 1 1 0 AAA domain MMR_HSR1 PF01926.23 ELR20034.1 - 0.022 14.8 0.0 0.049 13.7 0.0 1.6 1 0 0 1 1 1 0 50S ribosome-binding GTPase SMC_N PF02463.19 ELR20034.1 - 0.027 13.9 0.0 0.83 9.0 0.0 2.2 1 1 0 1 1 1 0 RecF/RecN/SMC N terminal domain NACHT PF05729.12 ELR20034.1 - 0.029 14.3 0.1 0.057 13.3 0.1 1.4 1 0 0 1 1 1 0 NACHT domain TsaE PF02367.17 ELR20034.1 - 0.052 13.6 0.1 0.096 12.7 0.1 1.3 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE dNK PF01712.19 ELR20034.1 - 0.059 13.2 0.0 0.095 12.5 0.0 1.4 1 0 0 1 1 1 0 Deoxynucleoside kinase NTPase_1 PF03266.15 ELR20034.1 - 0.068 13.1 0.1 0.59 10.0 0.1 2.1 2 0 0 2 2 2 0 NTPase AAA_33 PF13671.6 ELR20034.1 - 0.07 13.3 0.1 0.21 11.8 0.1 1.9 1 1 0 1 1 1 0 AAA domain SRP54 PF00448.22 ELR20034.1 - 0.075 12.6 0.2 0.13 11.9 0.2 1.3 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain ABC_ATPase PF09818.9 ELR20034.1 - 0.078 11.8 0.1 0.51 9.1 0.1 2.0 2 0 0 2 2 2 0 Predicted ATPase of the ABC class RuvB_N PF05496.12 ELR20034.1 - 0.089 12.5 0.0 0.17 11.6 0.0 1.4 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain AAA PF00004.29 ELR20034.1 - 0.1 13.0 0.0 0.27 11.6 0.0 1.8 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 ELR20034.1 - 0.12 12.3 0.0 0.23 11.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) ATPase_2 PF01637.18 ELR20034.1 - 0.13 12.2 0.0 0.22 11.4 0.0 1.3 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_14 PF13173.6 ELR20034.1 - 0.13 12.3 0.0 0.5 10.4 0.0 1.9 2 0 0 2 2 2 0 AAA domain ABC2_membrane_2 PF12679.7 ELR20034.1 - 4.7 6.4 11.4 0.7 9.1 5.7 2.1 2 0 0 2 2 2 0 ABC-2 family transporter protein Polyketide_cyc2 PF10604.9 ELR20035.1 - 0.036 14.3 1.0 0.066 13.5 1.0 1.4 1 0 0 1 1 1 0 Polyketide cyclase / dehydrase and lipid transport ABC2_membrane PF01061.24 ELR20036.1 - 4.6e-34 117.7 21.5 6.9e-34 117.1 21.5 1.3 1 0 0 1 1 1 1 ABC-2 type transporter ABC_tran PF00005.27 ELR20036.1 - 5.2e-27 95.0 0.0 9.5e-27 94.2 0.0 1.5 1 0 0 1 1 1 1 ABC transporter T2SSE PF00437.20 ELR20036.1 - 4.8e-06 25.8 0.5 0.00014 21.0 0.1 2.3 2 0 0 2 2 2 1 Type II/IV secretion system protein ABC2_membrane_3 PF12698.7 ELR20036.1 - 3.2e-05 23.2 13.8 3.2e-05 23.2 13.8 2.3 2 0 0 2 2 2 1 ABC-2 family transporter protein AAA_16 PF13191.6 ELR20036.1 - 0.00022 21.6 0.0 0.00036 21.0 0.0 1.3 1 0 0 1 1 1 1 AAA ATPase domain AAA_21 PF13304.6 ELR20036.1 - 0.0019 18.0 0.0 0.4 10.4 0.0 2.3 2 0 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system RsgA_GTPase PF03193.16 ELR20036.1 - 0.0021 18.0 0.1 0.0044 16.9 0.1 1.4 1 0 0 1 1 1 1 RsgA GTPase AAA_18 PF13238.6 ELR20036.1 - 0.0026 18.3 1.0 0.005 17.4 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 ELR20036.1 - 0.003 17.8 0.0 0.007 16.6 0.0 1.7 1 1 0 1 1 1 1 AAA domain AAA_25 PF13481.6 ELR20036.1 - 0.0044 16.6 0.0 0.0081 15.8 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_23 PF13476.6 ELR20036.1 - 0.0054 17.3 0.1 0.012 16.2 0.1 1.5 1 0 0 1 1 1 1 AAA domain DUF423 PF04241.15 ELR20036.1 - 0.0063 16.7 0.0 0.8 10.0 0.0 2.7 2 0 0 2 2 2 1 Protein of unknown function (DUF423) AAA_28 PF13521.6 ELR20036.1 - 0.011 16.0 0.0 0.028 14.7 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.6 ELR20036.1 - 0.015 15.0 0.0 0.026 14.3 0.0 1.3 1 0 0 1 1 1 0 AAA domain DUF87 PF01935.17 ELR20036.1 - 0.015 15.4 0.3 0.029 14.5 0.3 1.4 1 0 0 1 1 1 0 Helicase HerA, central domain ATP_bind_1 PF03029.17 ELR20036.1 - 0.019 14.7 0.0 0.035 13.9 0.0 1.4 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein AAA_33 PF13671.6 ELR20036.1 - 0.02 15.1 0.0 0.04 14.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.6 ELR20036.1 - 0.027 14.2 0.1 0.063 13.0 0.1 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain MMR_HSR1 PF01926.23 ELR20036.1 - 0.028 14.5 0.0 0.066 13.3 0.0 1.7 1 0 0 1 1 1 0 50S ribosome-binding GTPase dNK PF01712.19 ELR20036.1 - 0.031 14.1 0.0 0.055 13.3 0.0 1.5 1 0 0 1 1 1 0 Deoxynucleoside kinase NACHT PF05729.12 ELR20036.1 - 0.047 13.6 0.0 0.087 12.7 0.0 1.4 1 0 0 1 1 1 0 NACHT domain cobW PF02492.19 ELR20036.1 - 0.049 13.2 0.2 0.1 12.2 0.2 1.5 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain Cytidylate_kin PF02224.18 ELR20036.1 - 0.05 13.3 0.0 0.081 12.6 0.0 1.3 1 0 0 1 1 1 0 Cytidylate kinase AAA PF00004.29 ELR20036.1 - 0.065 13.7 0.0 0.22 12.0 0.0 1.9 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) SRP54 PF00448.22 ELR20036.1 - 0.072 12.7 0.1 0.15 11.6 0.1 1.5 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain NTPase_1 PF03266.15 ELR20036.1 - 0.088 12.7 0.0 0.54 10.1 0.0 2.0 2 0 0 2 2 2 0 NTPase ABC_ATPase PF09818.9 ELR20036.1 - 0.1 11.4 0.0 0.26 10.1 0.0 1.6 1 0 0 1 1 1 0 Predicted ATPase of the ABC class YqzM PF14141.6 ELR20036.1 - 0.12 12.4 0.5 0.42 10.7 0.0 2.2 2 0 0 2 2 1 0 YqzM-like protein TsaE PF02367.17 ELR20036.1 - 0.13 12.3 0.0 0.25 11.3 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE ATPase_2 PF01637.18 ELR20036.1 - 0.14 12.0 0.0 0.26 11.2 0.0 1.4 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea Rad17 PF03215.15 ELR20036.1 - 0.14 12.0 0.0 0.29 11.1 0.0 1.4 1 0 0 1 1 1 0 Rad17 P-loop domain RNA_helicase PF00910.22 ELR20036.1 - 0.15 12.5 0.0 0.36 11.2 0.0 1.7 1 0 0 1 1 1 0 RNA helicase ABC2_membrane_2 PF12679.7 ELR20036.1 - 7.5 5.7 11.6 0.63 9.3 6.2 1.9 2 0 0 2 2 2 0 ABC-2 family transporter protein Y_phosphatase3 PF13350.6 ELR20037.1 - 7.3e-36 124.3 0.0 1e-35 123.8 0.0 1.2 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase2 PF03162.13 ELR20037.1 - 1.8e-05 24.4 0.0 3.8e-05 23.3 0.0 1.5 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase PF00102.27 ELR20037.1 - 0.0016 18.1 0.0 0.0025 17.4 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Myotub-related PF06602.14 ELR20037.1 - 0.045 12.7 0.0 0.07 12.1 0.0 1.3 1 0 0 1 1 1 0 Myotubularin-like phosphatase domain DSPc PF00782.20 ELR20038.1 - 1.8e-29 102.3 0.0 2.2e-29 102.0 0.0 1.1 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 ELR20038.1 - 0.0023 17.6 0.0 0.0027 17.3 0.0 1.1 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Init_tRNA_PT PF04179.12 ELR20038.1 - 0.21 11.9 0.0 0.32 11.3 0.0 1.3 1 0 0 1 1 1 0 Rit1 DUSP-like domain PMSR PF01625.21 ELR20039.1 - 2.7e-63 212.7 1.7 3e-63 212.6 1.7 1.0 1 0 0 1 1 1 1 Peptide methionine sulfoxide reductase Lipase_GDSL PF00657.22 ELR20040.1 - 5.8e-07 29.7 0.0 1.1e-06 28.8 0.0 1.4 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Cu-binding_MopE PF11617.8 ELR20040.1 - 0.0042 17.2 3.3 0.023 14.9 3.3 2.3 1 1 0 1 1 1 1 Putative metal-binding motif Lipase_GDSL_2 PF13472.6 ELR20040.1 - 0.0044 17.4 0.3 0.012 16.0 0.1 1.9 2 0 0 2 2 2 1 GDSL-like Lipase/Acylhydrolase family SapB_2 PF03489.17 ELR20040.1 - 0.17 12.0 0.1 0.46 10.6 0.1 1.8 1 0 0 1 1 1 0 Saposin-like type B, region 2 CUB PF00431.20 ELR20041.1 - 1.4e-40 138.0 0.0 1.4e-13 51.1 0.0 3.9 4 0 0 4 4 4 3 CUB domain RasGAP PF00616.19 ELR20041.1 - 1.2e-15 57.8 2.9 1.1e-12 48.1 0.2 3.1 3 1 1 4 4 4 2 GTPase-activator protein for Ras-like GTPase DUF2207 PF09972.9 ELR20041.1 - 0.013 14.3 0.2 0.46 9.2 0.0 2.2 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) Folliculin PF11704.8 ELR20041.1 - 0.23 11.3 1.7 7.7 6.4 0.4 2.2 2 0 0 2 2 2 0 Vesicle coat protein involved in Golgi to plasma membrane transport Hep_59 PF07052.11 ELR20041.1 - 0.34 11.7 3.0 0.61 10.9 2.5 1.6 2 0 0 2 2 2 0 Hepatocellular carcinoma-associated antigen 59 SKG6 PF08693.10 ELR20041.1 - 1.1 8.8 6.1 2.5 7.6 6.1 1.6 1 0 0 1 1 1 0 Transmembrane alpha-helix domain DUF3742 PF12553.8 ELR20041.1 - 1.4 9.1 3.2 3.2 7.9 3.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3742) EloA-BP1 PF15870.5 ELR20042.1 - 0.00027 21.2 0.4 0.00027 21.2 0.4 3.0 3 1 0 3 3 3 1 ElonginA binding-protein 1 KIX PF02172.16 ELR20042.1 - 0.14 12.4 1.9 0.26 11.6 0.0 2.2 2 1 0 2 2 2 0 KIX domain LRR_9 PF14580.6 ELR20044.1 - 1.6e-12 47.3 5.6 3.5e-07 29.9 0.2 3.1 2 1 1 3 3 3 2 Leucine-rich repeat LRR_8 PF13855.6 ELR20044.1 - 9.3e-12 44.5 22.9 5.8e-07 29.2 3.5 3.9 2 1 1 3 3 3 3 Leucine rich repeat LRR_4 PF12799.7 ELR20044.1 - 4.5e-10 39.6 26.6 2e-05 24.8 3.0 4.6 3 1 2 5 5 5 3 Leucine Rich repeats (2 copies) DUF4954 PF16314.5 ELR20044.1 - 0.053 11.7 0.2 0.093 10.8 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4954) LRR_6 PF13516.6 ELR20044.1 - 7.2 6.9 18.6 5.4 7.3 0.1 5.3 5 0 0 5 5 5 0 Leucine Rich repeat DSHCT PF08148.12 ELR20045.1 - 2e-45 154.4 0.4 4.7e-45 153.2 0.4 1.7 1 0 0 1 1 1 1 DSHCT (NUC185) domain rRNA_proc-arch PF13234.6 ELR20045.1 - 6.6e-34 118.1 0.0 1.2e-33 117.2 0.0 1.5 1 0 0 1 1 1 1 rRNA-processing arch domain Ski2_N PF17911.1 ELR20045.1 - 1.9e-19 69.8 0.0 1.9e-19 69.8 0.0 2.5 2 0 0 2 2 2 1 Ski2 N-terminal region DEAD PF00270.29 ELR20045.1 - 2.4e-17 63.3 0.0 7e-17 61.8 0.0 1.8 1 0 0 1 1 1 1 DEAD/DEAH box helicase DUF2052 PF09747.9 ELR20045.1 - 0.0083 16.3 4.0 0.026 14.7 4.0 1.8 1 0 0 1 1 1 1 Coiled-coil domain containing protein (DUF2052) Helicase_C PF00271.31 ELR20045.1 - 0.01 16.2 0.0 0.041 14.2 0.0 2.1 2 0 0 2 2 2 0 Helicase conserved C-terminal domain RPN2_C PF18004.1 ELR20045.1 - 4.1 7.3 7.9 62 3.5 5.6 3.0 3 0 0 3 3 3 0 26S proteasome regulatory subunit RPN2 C-terminal domain CDC45 PF02724.14 ELR20045.1 - 5.8 5.1 6.1 9.5 4.4 6.1 1.2 1 0 0 1 1 1 0 CDC45-like protein IHABP4_N PF16174.5 ELR20045.1 - 9.6 6.8 14.1 0.59 10.7 6.5 2.4 2 0 0 2 2 2 0 Intracellular hyaluronan-binding protein 4 N-terminal MoeA_N PF03453.17 ELR20046.1 - 2.1e-37 128.3 5.5 3.1e-37 127.8 5.5 1.3 1 0 0 1 1 1 1 MoeA N-terminal region (domain I and II) MoCF_biosynth PF00994.24 ELR20046.1 - 2.5e-26 92.1 0.2 9.4e-26 90.2 0.0 1.9 2 0 0 2 2 2 1 Probable molybdopterin binding domain MoeA_C PF03454.15 ELR20046.1 - 2.6e-17 62.8 0.0 8.9e-17 61.0 0.0 2.0 1 0 0 1 1 1 1 MoeA C-terminal region (domain IV) DEP PF00610.21 ELR20047.1 - 1.9e-09 37.4 0.0 7.6e-09 35.5 0.0 2.0 2 0 0 2 2 2 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) Arabinose_Iso_C PF11762.8 ELR20047.1 - 0.077 12.8 0.0 0.17 11.7 0.0 1.6 1 0 0 1 1 1 0 L-arabinose isomerase C-terminal domain WASH-7_N PF14745.6 ELR20048.1 - 8.8e-150 499.9 0.4 1.2e-149 499.5 0.4 1.2 1 0 0 1 1 1 1 WASH complex subunit 7, N-terminal WASH-7_mid PF14744.6 ELR20048.1 - 1.4e-147 491.3 0.2 2.5e-147 490.5 0.2 1.4 1 0 0 1 1 1 1 WASH complex subunit 7 WASH-7_C PF14746.6 ELR20048.1 - 4.9e-60 202.2 1.4 9.8e-60 201.2 1.4 1.6 1 0 0 1 1 1 1 WASH complex subunit 7, C-terminal Complex1_LYR PF05347.15 ELR20049.1 - 1e-07 31.9 0.3 1.5e-07 31.4 0.3 1.3 1 0 0 1 1 1 1 Complex 1 protein (LYR family) AIG1 PF04548.16 ELR20050.1 - 1.1e-13 51.1 0.5 1.4e-13 50.6 0.5 1.2 1 0 0 1 1 1 1 AIG1 family MMR_HSR1 PF01926.23 ELR20050.1 - 0.0082 16.2 3.0 0.018 15.1 0.2 2.5 1 1 0 2 2 2 1 50S ribosome-binding GTPase AAA_23 PF13476.6 ELR20050.1 - 0.042 14.4 3.8 14 6.1 0.0 2.1 2 0 0 2 2 2 0 AAA domain Peptidase_A24 PF01478.18 ELR20050.1 - 0.077 13.4 0.5 0.17 12.3 0.5 1.5 1 0 0 1 1 1 0 Type IV leader peptidase family STAT_alpha PF01017.20 ELR20051.1 - 0.014 15.3 3.9 0.021 14.7 3.9 1.3 1 0 0 1 1 1 0 STAT protein, all-alpha domain RIC3 PF15361.6 ELR20051.1 - 0.47 10.9 2.3 0.97 9.8 2.3 1.5 1 0 0 1 1 1 0 Resistance to inhibitors of cholinesterase homologue 3 OmpH PF03938.14 ELR20051.1 - 5.8 7.3 16.9 5.7 7.3 16.1 1.4 1 1 0 1 1 1 0 Outer membrane protein (OmpH-like) RNase_T PF00929.24 ELR20052.1 - 5.1e-17 62.9 0.0 5.6e-17 62.8 0.0 1.0 1 0 0 1 1 1 1 Exonuclease DUF5051 PF16473.5 ELR20052.1 - 5.3e-06 26.5 0.0 6.2e-06 26.3 0.0 1.1 1 0 0 1 1 1 1 3' exoribonuclease, RNase T-like DNA_pol_A_exo1 PF01612.20 ELR20052.1 - 0.0086 15.8 0.0 0.024 14.3 0.0 1.8 1 1 0 1 1 1 1 3'-5' exonuclease DUF2390 PF09523.10 ELR20053.1 - 1.5 9.2 8.8 1.1 9.6 7.7 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF2390) AIG1 PF04548.16 ELR20054.1 - 1.1e-05 24.8 0.1 4.2e-05 23.0 0.0 1.9 2 1 0 2 2 2 1 AIG1 family MMR_HSR1 PF01926.23 ELR20054.1 - 0.0073 16.4 0.0 0.028 14.5 0.0 1.9 2 0 0 2 2 2 1 50S ribosome-binding GTPase ABC_tran PF00005.27 ELR20054.1 - 0.013 16.0 0.8 0.083 13.4 0.0 2.2 2 0 0 2 2 2 0 ABC transporter LytTR PF04397.15 ELR20054.1 - 0.053 13.7 0.1 0.1 12.8 0.1 1.4 1 0 0 1 1 1 0 LytTr DNA-binding domain KELK PF15796.5 ELR20054.1 - 0.099 13.1 8.9 0.054 13.9 6.4 1.8 1 1 0 1 1 1 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase FapA PF03961.13 ELR20054.1 - 0.13 10.9 1.5 0.17 10.4 1.5 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A AAA_23 PF13476.6 ELR20054.1 - 0.19 12.2 2.3 4.2 7.8 0.8 2.1 2 0 0 2 2 2 0 AAA domain OmpH PF03938.14 ELR20054.1 - 0.23 11.8 11.4 0.35 11.2 11.4 1.3 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) Rrn6 PF10214.9 ELR20054.1 - 0.44 9.0 2.0 0.49 8.8 2.0 1.1 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor AAA_22 PF13401.6 ELR20054.1 - 0.46 10.8 2.5 3.1 8.1 0.0 2.4 2 1 0 2 2 2 0 AAA domain AAA_32 PF13654.6 ELR20054.1 - 1.3 7.7 8.7 2.1 7.0 7.6 1.6 1 1 1 2 2 2 0 AAA domain PGBA_C PF15437.6 ELR20054.1 - 1.8 9.0 14.4 2.1 8.8 13.0 1.8 1 1 0 1 1 1 0 Plasminogen-binding protein pgbA C-terminal YlqD PF11068.8 ELR20054.1 - 8.3 6.8 11.3 15 6.0 5.9 2.0 1 1 1 2 2 2 0 YlqD protein UPF0242 PF06785.11 ELR20054.1 - 8.9 6.4 9.7 12 5.9 9.7 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus RNase_T PF00929.24 ELR20055.1 - 2.4e-17 64.0 0.0 2.6e-17 63.8 0.0 1.0 1 0 0 1 1 1 1 Exonuclease DUF5051 PF16473.5 ELR20055.1 - 5.3e-06 26.5 0.0 6.2e-06 26.3 0.0 1.1 1 0 0 1 1 1 1 3' exoribonuclease, RNase T-like DNA_pol_A_exo1 PF01612.20 ELR20055.1 - 0.0066 16.2 0.0 0.025 14.3 0.0 1.7 1 1 1 2 2 2 1 3'-5' exonuclease Nup153 PF08604.10 ELR20056.1 - 0.082 11.7 1.4 0.12 11.1 1.4 1.2 1 0 0 1 1 1 0 Nucleoporin Nup153-like GREB1 PF15782.5 ELR20056.1 - 4 4.4 6.8 5 4.1 6.8 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer U-box PF04564.15 ELR20057.1 - 2.2e-13 50.2 0.0 3.6e-13 49.5 0.0 1.3 1 0 0 1 1 1 1 U-box domain zf-rbx1 PF12678.7 ELR20057.1 - 2.1e-06 27.9 0.0 2.1e-06 27.9 0.0 1.8 2 0 0 2 2 2 1 RING-H2 zinc finger domain zf-Nse PF11789.8 ELR20057.1 - 5.4e-06 26.1 0.0 1.4e-05 24.8 0.0 1.7 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_2 PF13639.6 ELR20057.1 - 2.7e-05 24.4 0.0 2.7e-05 24.4 0.0 2.3 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_2 PF13923.6 ELR20057.1 - 9.5e-05 22.2 0.0 0.00026 20.8 0.0 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 ELR20057.1 - 0.0015 18.5 0.2 0.013 15.5 0.0 2.6 1 1 1 2 2 2 1 RING-type zinc-finger zf-ANAPC11 PF12861.7 ELR20057.1 - 0.0022 18.0 0.1 0.0055 16.7 0.1 1.6 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger Rtf2 PF04641.12 ELR20057.1 - 0.0068 15.8 0.1 0.011 15.1 0.1 1.3 1 0 0 1 1 1 1 Rtf2 RING-finger zf-C3HC4_3 PF13920.6 ELR20057.1 - 0.025 14.4 0.0 0.025 14.4 0.0 2.3 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 ELR20057.1 - 0.052 13.4 0.0 0.052 13.4 0.0 2.0 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) ERG4_ERG24 PF01222.17 ELR20058.1 - 4.6e-93 312.3 20.1 5.6e-93 312.0 20.1 1.0 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family DUF1295 PF06966.12 ELR20058.1 - 0.00014 21.5 2.5 0.00014 21.5 2.5 2.1 2 1 1 3 3 3 1 Protein of unknown function (DUF1295) ICMT PF04140.14 ELR20058.1 - 0.0059 17.0 0.6 0.019 15.4 0.0 2.1 2 0 0 2 2 2 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family AIG1 PF04548.16 ELR20059.1 - 8.3e-19 67.8 0.0 1.1e-18 67.3 0.0 1.1 1 0 0 1 1 1 1 AIG1 family MMR_HSR1 PF01926.23 ELR20059.1 - 0.0015 18.6 0.0 0.0046 17.0 0.0 1.8 1 1 1 2 2 2 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 ELR20059.1 - 0.053 13.4 0.0 0.12 12.3 0.0 1.5 1 0 0 1 1 1 0 RsgA GTPase SPATIAL PF15256.6 ELR20059.1 - 0.14 12.4 0.4 0.21 11.9 0.4 1.2 1 0 0 1 1 1 0 SPATIAL Kelch_4 PF13418.6 ELR20060.1 - 8.3e-34 115.4 8.7 1.5e-07 31.3 0.0 6.3 5 1 1 6 6 6 6 Galactose oxidase, central domain Kelch_1 PF01344.25 ELR20060.1 - 7.1e-28 95.9 6.4 4.9e-06 26.0 0.0 6.8 6 0 0 6 6 6 6 Kelch motif Kelch_6 PF13964.6 ELR20060.1 - 4.1e-26 90.4 5.0 0.0008 19.6 0.0 6.4 4 2 2 6 6 6 6 Kelch motif Kelch_3 PF13415.6 ELR20060.1 - 1.5e-25 89.0 2.6 2.1e-07 31.0 0.1 6.2 6 0 0 6 6 6 3 Galactose oxidase, central domain Kelch_5 PF13854.6 ELR20060.1 - 2.4e-25 88.1 1.8 3.2e-06 27.0 1.9 6.4 6 0 0 6 6 6 4 Kelch motif BTB PF00651.31 ELR20060.1 - 1.9e-22 79.6 0.3 1e-20 74.0 0.1 2.3 1 1 1 2 2 2 1 BTB/POZ domain Kelch_2 PF07646.15 ELR20060.1 - 2e-19 68.7 10.6 0.018 15.0 0.0 6.6 6 0 0 6 6 6 6 Kelch motif BACK PF07707.15 ELR20060.1 - 0.15 12.2 0.0 0.33 11.1 0.0 1.6 1 0 0 1 1 1 0 BTB And C-terminal Kelch PARP PF00644.20 ELR20061.1 - 1.4e-06 28.0 0.2 5.3e-06 26.2 0.1 2.0 2 1 0 2 2 2 1 Poly(ADP-ribose) polymerase catalytic domain SF-assemblin PF06705.11 ELR20061.1 - 2.4 7.4 7.2 1.6 8.0 0.0 2.7 3 0 0 3 3 3 0 SF-assemblin/beta giardin WWE PF02825.20 ELR20062.1 - 0.00081 19.9 0.0 0.0014 19.2 0.0 1.4 1 0 0 1 1 1 1 WWE domain F-box-like PF12937.7 ELR20063.1 - 3.3e-08 33.3 1.5 1e-07 31.7 1.5 1.9 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ELR20063.1 - 0.00055 19.7 0.1 0.0016 18.3 0.1 1.8 1 0 0 1 1 1 1 F-box domain ABC2_membrane PF01061.24 ELR20064.1 - 1.6e-64 217.2 40.3 8.3e-38 129.9 17.1 2.8 3 0 0 3 3 2 2 ABC-2 type transporter ABC_tran PF00005.27 ELR20064.1 - 1.4e-49 168.1 0.4 8.6e-26 91.1 0.0 2.4 2 0 0 2 2 2 2 ABC transporter RsgA_GTPase PF03193.16 ELR20064.1 - 2e-09 37.6 0.1 0.00095 19.1 0.0 2.3 2 0 0 2 2 2 2 RsgA GTPase AAA_21 PF13304.6 ELR20064.1 - 4.7e-09 36.5 0.1 0.23 11.2 0.0 4.3 3 1 1 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 ELR20064.1 - 1.2e-07 31.3 0.4 0.0054 16.4 0.1 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_22 PF13401.6 ELR20064.1 - 1.8e-07 31.5 0.0 0.017 15.4 0.0 2.7 2 0 0 2 2 2 2 AAA domain AAA_16 PF13191.6 ELR20064.1 - 1.3e-06 28.9 0.1 0.01 16.3 0.0 2.5 2 0 0 2 2 2 2 AAA ATPase domain AAA_18 PF13238.6 ELR20064.1 - 1.6e-06 28.7 0.1 0.012 16.2 0.0 2.5 2 0 0 2 2 2 2 AAA domain PDR_CDR PF06422.12 ELR20064.1 - 3.3e-06 26.9 3.0 0.00056 19.8 0.2 3.0 2 0 0 2 2 2 1 CDR ABC transporter AAA_25 PF13481.6 ELR20064.1 - 9e-06 25.4 1.4 0.084 12.4 0.0 2.6 2 1 0 2 2 2 2 AAA domain AAA_28 PF13521.6 ELR20064.1 - 1e-05 25.8 0.5 0.016 15.4 0.0 2.5 2 0 0 2 2 2 2 AAA domain MMR_HSR1 PF01926.23 ELR20064.1 - 2.2e-05 24.5 0.2 0.064 13.3 0.0 2.5 2 0 0 2 2 2 2 50S ribosome-binding GTPase RNA_helicase PF00910.22 ELR20064.1 - 4.7e-05 23.7 0.1 0.13 12.6 0.0 2.8 2 0 0 2 2 2 2 RNA helicase AAA_33 PF13671.6 ELR20064.1 - 0.00014 22.0 0.1 0.6 10.3 0.0 2.8 2 0 0 2 2 2 2 AAA domain Rad17 PF03215.15 ELR20064.1 - 0.00021 21.3 0.2 0.061 13.2 0.1 2.3 2 0 0 2 2 2 1 Rad17 P-loop domain AAA PF00004.29 ELR20064.1 - 0.0003 21.2 0.4 0.028 14.8 0.0 3.0 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 ELR20064.1 - 0.00038 20.5 0.4 0.026 14.5 0.0 2.6 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_30 PF13604.6 ELR20064.1 - 0.0006 19.6 0.5 0.98 9.1 0.0 2.4 2 0 0 2 2 2 2 AAA domain Zeta_toxin PF06414.12 ELR20064.1 - 0.0007 18.9 0.6 0.21 10.8 0.0 2.4 2 0 0 2 2 2 1 Zeta toxin Viral_helicase1 PF01443.18 ELR20064.1 - 0.00073 19.4 0.2 0.0034 17.1 0.0 2.1 2 0 0 2 2 2 1 Viral (Superfamily 1) RNA helicase DUF815 PF05673.13 ELR20064.1 - 0.00088 18.5 0.2 0.034 13.3 0.0 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF815) NACHT PF05729.12 ELR20064.1 - 0.0016 18.4 3.9 0.037 13.9 0.2 2.4 2 0 0 2 2 2 1 NACHT domain AAA_23 PF13476.6 ELR20064.1 - 0.002 18.7 0.0 1.6 9.2 0.0 2.6 2 0 0 2 2 2 1 AAA domain Ploopntkinase3 PF18751.1 ELR20064.1 - 0.0025 17.8 0.3 3.2 7.6 0.0 2.9 3 0 0 3 3 3 1 P-loop Nucleotide Kinase3 NTPase_1 PF03266.15 ELR20064.1 - 0.0055 16.6 0.6 0.85 9.5 0.1 3.3 3 0 0 3 3 3 1 NTPase MeaB PF03308.16 ELR20064.1 - 0.011 14.8 0.4 0.65 8.9 0.0 2.3 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_14 PF13173.6 ELR20064.1 - 0.027 14.5 0.1 1.3 9.0 0.0 2.5 2 0 0 2 2 2 0 AAA domain IstB_IS21 PF01695.17 ELR20064.1 - 0.034 13.9 0.1 6 6.6 0.0 2.4 2 0 0 2 2 2 0 IstB-like ATP binding protein TsaE PF02367.17 ELR20064.1 - 0.038 14.0 1.0 7.1 6.7 0.0 2.4 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_17 PF13207.6 ELR20064.1 - 0.047 14.1 0.1 1.8 9.0 0.0 2.5 2 0 0 2 2 2 0 AAA domain APS_kinase PF01583.20 ELR20064.1 - 0.061 13.2 0.1 2.6 7.9 0.0 2.5 2 0 0 2 2 2 0 Adenylylsulphate kinase DUF87 PF01935.17 ELR20064.1 - 0.071 13.2 4.5 0.95 9.5 0.8 2.6 2 0 0 2 2 2 0 Helicase HerA, central domain AAA_7 PF12775.7 ELR20064.1 - 0.1 12.1 0.9 2.7 7.5 0.0 2.3 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_24 PF13479.6 ELR20064.1 - 0.11 12.2 1.3 10 5.8 0.2 2.5 2 0 0 2 2 2 0 AAA domain NB-ARC PF00931.22 ELR20064.1 - 0.14 11.3 0.4 14 4.8 0.0 2.3 2 0 0 2 2 2 0 NB-ARC domain ATPase_2 PF01637.18 ELR20064.1 - 0.18 11.7 0.0 6.1 6.7 0.0 2.3 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea cobW PF02492.19 ELR20064.1 - 0.24 11.0 3.3 9.9 5.7 0.3 2.6 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain PduV-EutP PF10662.9 ELR20064.1 - 0.63 9.8 1.7 16 5.2 0.2 2.4 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation dNK PF01712.19 ELR20064.1 - 1.1 9.0 5.5 9.2 6.1 0.0 3.4 4 0 0 4 4 3 0 Deoxynucleoside kinase ABC2_membrane_3 PF12698.7 ELR20064.1 - 3.5 6.6 38.4 8.9 5.3 9.0 3.7 3 2 0 3 3 3 0 ABC-2 family transporter protein Peptidase_M28 PF04389.17 ELR20065.1 - 1e-20 74.3 0.1 1.9e-20 73.4 0.0 1.5 2 0 0 2 2 2 1 Peptidase family M28 Peptidase_M20 PF01546.28 ELR20065.1 - 7.5e-06 25.8 0.1 2e-05 24.4 0.1 1.7 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 PA PF02225.22 ELR20065.1 - 8.1e-05 22.6 0.4 0.00019 21.4 0.4 1.6 1 0 0 1 1 1 1 PA domain SH3_9 PF14604.6 ELR20066.1 - 3.7e-17 61.9 0.1 6.4e-17 61.1 0.1 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 ELR20066.1 - 4.1e-16 58.3 0.1 7.9e-16 57.4 0.1 1.5 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 ELR20066.1 - 1.3e-13 50.4 0.0 2.6e-13 49.4 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain FCH PF00611.23 ELR20066.1 - 2.3e-13 50.2 0.8 2.3e-13 50.2 0.8 4.2 3 1 0 3 3 3 1 Fes/CIP4, and EFC/F-BAR homology domain HR1 PF02185.16 ELR20066.1 - 0.0019 18.3 2.4 0.0062 16.6 1.4 2.5 1 1 0 1 1 1 1 Hr1 repeat DUF1664 PF07889.12 ELR20066.1 - 0.044 13.8 0.2 0.044 13.8 0.2 3.6 3 1 0 3 3 3 0 Protein of unknown function (DUF1664) Enkurin PF13864.6 ELR20066.1 - 0.061 13.8 0.8 0.061 13.8 0.8 4.8 3 1 2 5 5 5 0 Calmodulin-binding DUF5320 PF17253.2 ELR20066.1 - 0.93 10.6 2.2 28 5.9 0.2 2.9 2 0 0 2 2 2 0 Family of unknown function (DUF5320) Vps5 PF09325.10 ELR20066.1 - 5.3 6.5 36.1 0.038 13.5 22.4 3.3 2 2 1 3 3 3 0 Vps5 C terminal like SlyX PF04102.12 ELR20066.1 - 9.9 6.9 9.1 3.5 8.3 0.1 4.1 4 1 1 5 5 5 0 SlyX SNARE PF05739.19 ELR20067.1 - 1.8e-05 24.6 0.8 1.8e-05 24.6 0.8 2.1 3 0 0 3 3 3 1 SNARE domain V-SNARE_C PF12352.8 ELR20067.1 - 2e-05 24.8 0.4 2e-05 24.8 0.4 1.8 1 1 1 2 2 2 1 Snare region anchored in the vesicle membrane C-terminus DUF16 PF01519.16 ELR20067.1 - 0.061 13.8 0.7 0.086 13.3 0.7 1.2 1 0 0 1 1 1 0 Protein of unknown function DUF16 BAR_3_WASP_bdg PF10456.9 ELR20067.1 - 0.22 11.0 1.7 0.69 9.3 0.1 1.9 1 1 0 2 2 2 0 WASP-binding domain of Sorting nexin protein NPV_P10 PF05531.12 ELR20067.1 - 0.3 11.6 1.9 1.3 9.6 0.1 2.1 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein RhoGEF PF00621.20 ELR20068.1 - 3e-29 102.6 0.5 6.9e-29 101.4 0.5 1.6 1 0 0 1 1 1 1 RhoGEF domain C2 PF00168.30 ELR20068.1 - 1.6e-15 57.2 0.0 4.2e-15 55.9 0.0 1.7 1 0 0 1 1 1 1 C2 domain zf-RING_2 PF13639.6 ELR20069.1 - 4.2e-06 27.0 20.1 6.6e-06 26.4 20.1 1.3 1 0 0 1 1 1 1 Ring finger domain Prok-RING_4 PF14447.6 ELR20069.1 - 0.013 15.4 17.6 0.026 14.4 17.6 1.5 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-rbx1 PF12678.7 ELR20069.1 - 0.035 14.4 15.0 0.097 13.0 15.0 1.7 1 0 0 1 1 1 0 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 ELR20069.1 - 0.048 13.5 18.7 0.084 12.8 18.7 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Baculo_IE-1 PF05290.11 ELR20069.1 - 0.064 13.2 10.5 0.1 12.6 10.5 1.2 1 0 0 1 1 1 0 Baculovirus immediate-early protein (IE-0) zf-C3HC4_3 PF13920.6 ELR20069.1 - 0.095 12.6 20.6 0.14 12.0 20.6 1.3 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ELR20069.1 - 0.47 10.5 17.3 1 9.4 17.3 1.6 1 0 0 1 1 1 0 zinc-RING finger domain zf-C3HC4_2 PF13923.6 ELR20069.1 - 1 9.3 18.2 1.8 8.5 18.2 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 ELR20069.1 - 3.5 7.7 14.0 0.87 9.7 8.4 2.2 1 1 1 2 2 2 0 RING-type zinc-finger F-box-like PF12937.7 ELR20070.1 - 0.00014 21.7 0.1 0.00014 21.7 0.1 1.9 2 0 0 2 2 2 1 F-box-like Macro PF01661.21 ELR20071.1 - 1.6e-36 124.9 0.2 3.8e-36 123.7 0.2 1.7 1 0 0 1 1 1 1 Macro domain NCE101 PF11654.8 ELR20071.1 - 0.21 11.3 0.1 0.48 10.2 0.1 1.5 1 0 0 1 1 1 0 Non-classical export protein 1 Cwf_Cwc_15 PF04889.12 ELR20071.1 - 1.7 8.3 61.1 1.4 8.6 40.4 2.7 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein Nop14 PF04147.12 ELR20071.1 - 5.5 5.1 59.6 3.6 5.7 5.3 2.1 2 0 0 2 2 2 0 Nop14-like family V_ATPase_I PF01496.19 ELR20071.1 - 8.5 4.1 14.1 15 3.3 14.1 1.4 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Kelch_6 PF13964.6 ELR20072.1 - 4.8e-39 131.4 10.8 6.4e-08 32.6 0.0 6.3 4 2 2 6 6 6 6 Kelch motif Kelch_4 PF13418.6 ELR20072.1 - 7.3e-29 99.5 9.9 7.6e-07 29.0 0.0 6.3 5 1 1 6 6 6 4 Galactose oxidase, central domain Kelch_1 PF01344.25 ELR20072.1 - 7.7e-28 95.8 19.3 1.7e-09 37.1 0.1 6.2 6 0 0 6 6 6 4 Kelch motif Kelch_3 PF13415.6 ELR20072.1 - 1.4e-26 92.2 11.2 0.00044 20.5 0.0 7.4 7 1 0 7 7 7 5 Galactose oxidase, central domain Kelch_2 PF07646.15 ELR20072.1 - 2.2e-23 81.3 16.0 0.00017 21.5 0.0 6.6 6 1 0 6 6 6 6 Kelch motif Kelch_5 PF13854.6 ELR20072.1 - 1.4e-22 79.2 15.0 8.3e-05 22.5 0.4 6.1 6 0 0 6 6 6 5 Kelch motif F-box-like PF12937.7 ELR20072.1 - 4.5e-07 29.6 0.2 1.1e-06 28.4 0.2 1.7 1 0 0 1 1 1 1 F-box-like F-box_4 PF15966.5 ELR20072.1 - 0.064 13.1 0.0 0.16 11.8 0.0 1.7 1 0 0 1 1 1 0 F-box DUF4015 PF13200.6 ELR20073.1 - 4.9e-18 65.2 1.7 6.7e-18 64.8 1.7 1.1 1 0 0 1 1 1 1 Putative glycosyl hydrolase domain GHL10 PF02638.15 ELR20073.1 - 1.3e-14 54.0 2.4 1.8e-14 53.6 2.4 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase-like 10 GHL13 PF14883.6 ELR20073.1 - 1.1e-08 34.6 0.6 1.5e-08 34.1 0.6 1.1 1 0 0 1 1 1 1 Hypothetical glycosyl hydrolase family 13 GHL6 PF14871.6 ELR20073.1 - 0.078 13.1 0.0 0.21 11.7 0.0 1.7 1 1 0 1 1 1 0 Hypothetical glycosyl hydrolase 6 TPR_12 PF13424.6 ELR20074.1 - 5.1e-83 273.4 47.5 9e-19 67.6 1.4 9.8 6 2 4 10 10 9 9 Tetratricopeptide repeat TPR_10 PF13374.6 ELR20074.1 - 7.2e-65 213.3 33.2 2.5e-09 36.7 0.0 12.6 12 0 0 12 12 12 11 Tetratricopeptide repeat TPR_1 PF00515.28 ELR20074.1 - 1.1e-36 123.1 41.0 5.9e-07 29.0 0.9 11.2 11 0 0 11 11 11 8 Tetratricopeptide repeat TPR_2 PF07719.17 ELR20074.1 - 2.5e-33 111.5 48.4 3.5e-05 23.6 0.5 11.7 11 0 0 11 11 11 9 Tetratricopeptide repeat TPR_7 PF13176.6 ELR20074.1 - 4.9e-29 98.2 24.9 0.00011 22.0 0.1 10.9 10 0 0 10 10 10 8 Tetratricopeptide repeat TPR_8 PF13181.6 ELR20074.1 - 2.7e-23 80.2 29.3 0.00016 21.6 0.3 10.9 10 0 0 10 10 10 6 Tetratricopeptide repeat AlbA_2 PF04326.14 ELR20074.1 - 3.1e-15 56.6 0.0 6.6e-15 55.5 0.0 1.6 1 0 0 1 1 1 1 Putative DNA-binding domain NB-ARC PF00931.22 ELR20074.1 - 1.4e-12 47.3 0.0 3.5e-12 46.0 0.0 1.7 1 0 0 1 1 1 1 NB-ARC domain TPR_17 PF13431.6 ELR20074.1 - 7e-08 32.3 18.9 1.3 9.6 0.0 9.4 10 0 0 10 10 10 3 Tetratricopeptide repeat AAA_16 PF13191.6 ELR20074.1 - 2e-05 25.0 0.0 2e-05 25.0 0.0 3.0 2 1 0 2 2 1 1 AAA ATPase domain NACHT PF05729.12 ELR20074.1 - 4.2e-05 23.5 0.0 0.00024 21.0 0.0 2.3 2 0 0 2 2 2 1 NACHT domain SHNi-TPR PF10516.9 ELR20074.1 - 7.8e-05 22.0 6.5 0.23 10.9 0.0 5.1 5 0 0 5 5 4 1 SHNi-TPR TPR_14 PF13428.6 ELR20074.1 - 0.00013 22.5 35.1 0.43 11.5 0.0 11.1 10 3 3 13 13 9 2 Tetratricopeptide repeat ATPase_2 PF01637.18 ELR20074.1 - 0.00015 21.8 0.7 0.00072 19.5 0.0 2.4 2 0 0 2 2 2 1 ATPase domain predominantly from Archaea RP-C_C PF11800.8 ELR20074.1 - 0.0019 18.3 10.1 0.0019 18.3 10.1 2.2 2 0 0 2 2 1 1 Replication protein C C-terminal region TPR_16 PF13432.6 ELR20074.1 - 0.0037 17.9 0.3 0.018 15.7 0.1 10.8 9 3 1 10 10 8 4 Tetratricopeptide repeat TPR_19 PF14559.6 ELR20074.1 - 0.0063 17.0 31.5 1.7 9.2 0.0 8.1 7 1 1 8 8 7 3 Tetratricopeptide repeat TPR_11 PF13414.6 ELR20074.1 - 0.013 15.2 31.7 2.6 7.8 0.0 8.7 9 1 1 10 10 9 0 TPR repeat Snapin_Pallidin PF14712.6 ELR20074.1 - 0.018 15.5 0.0 0.16 12.4 0.0 2.7 2 0 0 2 2 1 0 Snapin/Pallidin Orf78 PF06024.12 ELR20074.1 - 0.042 14.1 0.1 0.042 14.1 0.1 2.2 2 0 0 2 2 1 0 Orf78 (ac78) AAA PF00004.29 ELR20074.1 - 0.057 13.8 0.0 0.16 12.4 0.0 1.8 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) TsaE PF02367.17 ELR20074.1 - 0.062 13.3 0.0 0.15 12.1 0.0 1.6 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE ANAPC3 PF12895.7 ELR20074.1 - 0.087 13.1 20.3 5.3 7.3 0.0 7.1 5 1 0 6 6 6 0 Anaphase-promoting complex, cyclosome, subunit 3 AAA_31 PF13614.6 ELR20074.1 - 0.12 12.3 0.1 0.24 11.3 0.1 1.5 1 0 0 1 1 1 0 AAA domain AAA_5 PF07728.14 ELR20074.1 - 0.13 12.3 0.0 0.47 10.5 0.0 2.0 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) CbiA PF01656.23 ELR20074.1 - 0.16 12.1 0.2 0.56 10.3 0.2 2.0 1 0 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain PPR PF01535.20 ELR20074.1 - 1.4 9.3 3.6 90 3.7 0.0 4.4 3 0 0 3 3 3 0 PPR repeat Mito_carr PF00153.27 ELR20075.1 - 6.7e-10 38.8 0.7 2e-09 37.3 0.0 2.1 2 0 0 2 2 2 1 Mitochondrial carrier protein MAGE_N PF12440.8 ELR20075.1 - 1.7 9.4 20.0 1.1 10.0 16.5 2.1 2 0 0 2 2 2 0 Melanoma associated antigen family N terminal CH PF00307.31 ELR20076.1 - 7.3e-11 42.2 0.0 1.5e-10 41.2 0.0 1.5 1 0 0 1 1 1 1 Calponin homology (CH) domain CDC24 PF06395.11 ELR20076.1 - 0.021 15.0 0.0 0.045 14.0 0.0 1.5 1 0 0 1 1 1 0 CDC24 Calponin MCM PF00493.23 ELR20077.1 - 1.9e-103 344.4 0.1 3.2e-103 343.7 0.1 1.3 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 ELR20077.1 - 1e-37 128.8 0.0 2.2e-37 127.7 0.0 1.5 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 ELR20077.1 - 4.1e-25 88.0 5.5 4.6e-25 87.9 1.4 3.1 4 0 0 4 4 4 1 MCM AAA-lid domain MCM6_C PF18263.1 ELR20077.1 - 3.8e-19 68.9 0.1 1.3e-18 67.1 0.1 2.0 1 0 0 1 1 1 1 MCM6 C-terminal winged-helix domain MCM_N PF14551.6 ELR20077.1 - 4.1e-14 53.0 1.5 9.6e-14 51.8 0.3 2.2 2 0 0 2 2 2 1 MCM N-terminal domain Mg_chelatase PF01078.21 ELR20077.1 - 1.5e-07 31.1 0.0 1.5e-06 27.8 0.0 2.2 1 1 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_3 PF07726.11 ELR20077.1 - 0.002 18.0 0.0 0.004 17.0 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 ELR20077.1 - 0.0024 17.6 0.0 0.0064 16.2 0.0 1.6 1 0 0 1 1 1 1 Sigma-54 interaction domain AAA_5 PF07728.14 ELR20077.1 - 0.0036 17.3 0.0 0.015 15.3 0.0 2.1 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) Med4 PF10018.9 ELR20078.1 - 3.7e-20 72.4 0.1 5.5e-20 71.9 0.1 1.2 1 0 0 1 1 1 1 Vitamin-D-receptor interacting Mediator subunit 4 RmuC PF02646.16 ELR20078.1 - 0.022 13.9 1.0 0.033 13.3 1.0 1.2 1 0 0 1 1 1 0 RmuC family GAT PF03127.14 ELR20078.1 - 0.21 11.9 2.7 1.9 8.8 0.3 2.4 1 1 1 2 2 2 0 GAT domain HABP4_PAI-RBP1 PF04774.15 ELR20079.1 - 1.5e-14 54.8 7.1 1.5e-14 54.8 7.1 3.9 5 0 0 5 5 5 1 Hyaluronan / mRNA binding family DUF2678 PF10856.8 ELR20080.1 - 0.001 19.0 6.0 0.0017 18.2 6.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2678) DUF3789 PF12664.7 ELR20080.1 - 0.068 12.9 1.9 0.23 11.2 1.9 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF3789) DUF4131 PF13567.6 ELR20080.1 - 0.46 10.1 7.5 0.38 10.4 0.4 1.7 1 1 1 2 2 2 0 Domain of unknown function (DUF4131) DUF2231 PF09990.9 ELR20080.1 - 0.69 10.4 8.3 2.2 8.7 8.2 1.8 1 1 0 1 1 1 0 Predicted membrane protein (DUF2231) VirB3 PF05101.13 ELR20080.1 - 0.7 10.2 11.6 3 8.1 11.6 2.1 1 1 0 1 1 1 0 Type IV secretory pathway, VirB3-like protein DUF2070 PF09843.9 ELR20080.1 - 6.3 5.0 5.9 7.6 4.7 5.9 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) SPC12 PF06645.13 ELR20080.1 - 8 6.6 13.8 0.11 12.6 4.1 2.5 1 1 1 2 2 2 0 Microsomal signal peptidase 12 kDa subunit (SPC12) Sigma_reg_N PF13800.6 ELR20080.1 - 9.1 6.6 7.0 38 4.7 3.2 2.3 2 1 0 2 2 2 0 Sigma factor regulator N-terminal PA28_beta PF02252.18 ELR20081.1 - 2e-50 170.2 0.1 3.2e-50 169.6 0.1 1.3 1 0 0 1 1 1 1 Proteasome activator pa28 beta subunit PA28_alpha PF02251.18 ELR20081.1 - 6.3e-08 32.6 0.0 1.2e-07 31.7 0.0 1.5 1 0 0 1 1 1 1 Proteasome activator pa28 alpha subunit CAP PF00188.26 ELR20082.1 - 0.017 15.9 0.1 0.02 15.8 0.1 1.2 1 0 0 1 1 1 0 Cysteine-rich secretory protein family Pkinase PF00069.25 ELR20083.1 - 5.1e-63 212.9 0.0 7.5e-63 212.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR20083.1 - 1.1e-45 156.0 0.0 1.5e-45 155.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ELR20083.1 - 2.7e-06 26.9 0.0 5.2e-06 26.0 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 ELR20083.1 - 7.8e-05 21.6 0.0 0.00012 21.0 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase KIND PF16474.5 ELR20083.1 - 0.004 17.1 0.0 0.0087 16.0 0.0 1.5 1 0 0 1 1 1 1 Kinase non-catalytic C-lobe domain FTA2 PF13095.6 ELR20083.1 - 0.0047 16.6 0.1 1.2 8.7 0.0 2.2 2 0 0 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 Kdo PF06293.14 ELR20083.1 - 0.0053 16.1 0.3 0.012 14.9 0.1 1.6 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 ELR20083.1 - 0.0075 15.2 0.2 0.022 13.7 0.2 1.7 1 1 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 ELR20083.1 - 0.0099 15.8 0.0 0.047 13.6 0.0 2.0 1 1 1 2 2 2 1 Phosphotransferase enzyme family Complex1_LYR_2 PF13233.6 ELR20084.1 - 1.5e-07 32.1 0.0 1.8e-07 31.8 0.0 1.3 1 1 0 1 1 1 1 Complex1_LYR-like Complex1_LYR PF05347.15 ELR20084.1 - 0.00017 21.6 0.0 0.00026 21.0 0.0 1.4 1 0 0 1 1 1 1 Complex 1 protein (LYR family) DUF5641 PF18701.1 ELR20084.1 - 0.038 14.1 0.0 0.048 13.8 0.0 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5641) Pmp3 PF01679.17 ELR20085.1 - 9e-15 54.6 13.4 1.1e-14 54.4 13.4 1.1 1 0 0 1 1 1 1 Proteolipid membrane potential modulator RNA_pol_Rpb2_6 PF00562.28 ELR20086.1 - 1.1e-99 334.2 0.0 1.8e-98 330.1 0.0 2.1 1 1 1 2 2 2 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.15 ELR20086.1 - 1.4e-51 174.9 0.4 1.9e-51 174.4 0.4 1.2 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_7 PF04560.20 ELR20086.1 - 1.6e-34 118.1 1.1 2.7e-34 117.4 0.2 2.0 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_4 PF04566.13 ELR20086.1 - 5.5e-25 87.4 0.4 1.5e-24 86.0 0.4 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 4 RNA_pol_Rpb2_3 PF04565.16 ELR20086.1 - 5.9e-20 71.2 0.0 1.1e-19 70.3 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_2 PF04561.14 ELR20086.1 - 4.9e-15 55.7 0.4 3.2e-06 26.9 0.0 2.5 1 1 1 2 2 2 2 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_5 PF04567.17 ELR20086.1 - 5.4e-09 36.5 0.3 1.8e-08 34.8 0.3 2.0 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 5 Pkinase PF00069.25 ELR20087.1 - 1.8e-43 148.8 0.1 8.8e-21 74.4 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ELR20087.1 - 1.1e-15 57.7 0.6 7.4e-11 41.8 0.1 2.5 3 0 0 3 3 3 2 Protein tyrosine kinase APH PF01636.23 ELR20087.1 - 0.028 14.3 0.3 2.7 7.9 0.0 2.7 2 1 0 3 3 3 0 Phosphotransferase enzyme family DNA_pol_phi PF04931.13 ELR20087.1 - 0.084 11.0 5.5 0.24 9.5 5.5 1.7 1 0 0 1 1 1 0 DNA polymerase phi AAR2 PF05282.11 ELR20087.1 - 1.6 8.1 6.4 0.16 11.3 1.8 1.7 2 0 0 2 2 2 0 AAR2 protein Nop14 PF04147.12 ELR20087.1 - 1.6 6.8 19.3 0.043 12.1 11.3 1.9 2 0 0 2 2 2 0 Nop14-like family HAT PF02184.16 ELR20088.1 - 8e-19 67.3 64.6 1e-06 28.6 0.3 14.1 13 1 0 13 13 13 6 HAT (Half-A-TPR) repeat TPR_14 PF13428.6 ELR20088.1 - 5.7e-15 54.7 43.5 0.022 15.6 0.3 11.1 4 4 6 11 11 11 5 Tetratricopeptide repeat TPR_16 PF13432.6 ELR20088.1 - 7.9e-14 52.0 25.1 3.7e-05 24.3 0.3 6.8 5 1 1 6 6 6 3 Tetratricopeptide repeat TPR_19 PF14559.6 ELR20088.1 - 7.5e-13 48.8 10.9 0.091 13.3 0.0 7.5 6 2 2 8 8 7 5 Tetratricopeptide repeat Suf PF05843.14 ELR20088.1 - 4.1e-12 46.7 20.6 4.5e-07 30.1 0.5 5.9 1 1 4 5 5 5 3 Suppressor of forked protein (Suf) TPR_2 PF07719.17 ELR20088.1 - 1.1e-07 31.4 24.4 1.2 9.5 0.0 9.5 9 0 0 9 9 9 1 Tetratricopeptide repeat Mad3_BUB1_I PF08311.12 ELR20088.1 - 9.3e-07 28.9 28.6 0.015 15.2 0.9 7.4 6 1 0 6 6 6 2 Mad3/BUB1 homology region 1 TPR_8 PF13181.6 ELR20088.1 - 1.6e-05 24.7 15.9 12 6.4 0.1 7.6 8 0 0 8 8 7 0 Tetratricopeptide repeat TPR_15 PF13429.6 ELR20088.1 - 0.00034 19.9 27.2 0.21 10.7 1.6 5.9 3 3 2 5 5 5 4 Tetratricopeptide repeat TPR_17 PF13431.6 ELR20088.1 - 0.00043 20.5 16.0 0.014 15.7 0.0 7.1 8 0 0 8 8 7 1 Tetratricopeptide repeat TPR_12 PF13424.6 ELR20088.1 - 0.00071 19.8 24.1 0.66 10.3 0.3 7.6 6 2 1 7 7 7 1 Tetratricopeptide repeat BSD PF03909.17 ELR20088.1 - 0.0028 17.6 1.9 0.21 11.6 0.1 3.0 2 0 0 2 2 2 1 BSD domain TPR_6 PF13174.6 ELR20088.1 - 0.003 18.1 28.0 2.2 9.1 0.0 9.5 11 1 1 12 12 9 1 Tetratricopeptide repeat MIT PF04212.18 ELR20088.1 - 0.0091 16.0 7.5 16 5.6 0.0 5.5 4 0 0 4 4 4 0 MIT (microtubule interacting and transport) domain Fis1_TPR_C PF14853.6 ELR20088.1 - 0.091 12.8 3.5 11 6.1 0.0 4.6 5 0 0 5 5 5 0 Fis1 C-terminal tetratricopeptide repeat QIL1 PF15884.5 ELR20088.1 - 0.11 13.1 2.5 4 8.1 0.0 4.0 4 0 0 4 4 3 0 MICOS complex subunit MIC13, QIL1 CKAP2_C PF15297.6 ELR20088.1 - 0.21 10.7 5.5 2.8 6.9 0.0 3.6 4 0 0 4 4 4 0 Cytoskeleton-associated protein 2 C-terminus TPR_11 PF13414.6 ELR20088.1 - 0.27 11.0 0.0 0.27 11.0 0.0 4.6 5 0 0 5 5 5 0 TPR repeat U3_assoc_6 PF08640.11 ELR20088.1 - 0.45 10.6 19.8 0.28 11.3 0.7 6.5 5 3 3 8 8 8 0 U3 small nucleolar RNA-associated protein 6 TPR_7 PF13176.6 ELR20088.1 - 1.5 9.1 22.8 0.72 10.0 0.1 7.0 8 0 0 8 8 7 0 Tetratricopeptide repeat DEAD PF00270.29 ELR20089.1 - 2.7e-36 125.0 0.1 5e-34 117.6 0.0 2.4 1 1 1 2 2 2 2 DEAD/DEAH box helicase Helicase_C PF00271.31 ELR20089.1 - 6.1e-27 94.2 0.0 2.4e-26 92.2 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 ELR20089.1 - 0.0033 17.4 0.0 0.0072 16.3 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit FKBP_N PF01346.18 ELR20089.1 - 0.26 12.3 1.9 0.69 10.9 1.9 1.7 1 0 0 1 1 1 0 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase DUF608 PF04685.13 ELR20092.1 - 1.4e-120 402.7 0.4 5.7e-90 302.1 0.1 2.1 2 0 0 2 2 2 2 Glycosyl-hydrolase family 116, catalytic region Glyco_hydr_116N PF12215.8 ELR20092.1 - 3.3e-87 292.9 0.0 4.5e-87 292.4 0.0 1.2 1 0 0 1 1 1 1 beta-glucosidase 2, glycosyl-hydrolase family 116 N-term Glyco_hydro_52 PF03512.13 ELR20092.1 - 0.019 13.9 0.0 0.038 13.0 0.0 1.4 1 0 0 1 1 1 0 Glycosyl hydrolase family 52 EF-hand_5 PF13202.6 ELR20092.1 - 0.051 13.1 0.0 0.11 12.1 0.0 1.6 1 0 0 1 1 1 0 EF hand Metallophos PF00149.28 ELR20094.1 - 1.6e-25 90.8 0.0 3e-25 89.9 0.0 1.5 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase SAM_1 PF00536.30 ELR20095.1 - 1.3e-10 41.5 0.1 2.4e-10 40.7 0.1 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 ELR20095.1 - 2.6e-09 37.1 0.1 5e-09 36.1 0.1 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Ank_2 PF12796.7 ELR20096.1 - 4.1e-22 78.6 0.0 1.3e-12 48.1 0.0 3.8 1 1 3 4 4 4 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ELR20096.1 - 2.6e-20 72.5 0.9 9.6e-08 32.4 0.1 4.7 2 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank PF00023.30 ELR20096.1 - 9.8e-20 70.1 1.3 0.00044 20.6 0.0 5.5 5 0 0 5 5 5 4 Ankyrin repeat Ank_5 PF13857.6 ELR20096.1 - 1.5e-14 53.9 1.3 7.2e-05 23.0 0.1 4.9 3 1 2 5 5 5 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 ELR20096.1 - 3.2e-14 51.6 0.1 0.0011 19.2 0.0 5.9 5 1 0 5 5 5 2 Ankyrin repeat SDA1 PF05285.12 ELR20096.1 - 0.0014 18.1 3.8 0.002 17.6 3.8 1.2 1 0 0 1 1 1 1 SDA1 BUD22 PF09073.10 ELR20096.1 - 0.0028 17.1 4.2 0.0037 16.7 4.2 1.2 1 0 0 1 1 1 1 BUD22 Nop14 PF04147.12 ELR20096.1 - 0.003 15.9 4.0 0.0038 15.5 4.0 1.1 1 0 0 1 1 1 1 Nop14-like family Utp14 PF04615.13 ELR20096.1 - 0.0039 15.8 0.7 0.0051 15.5 0.7 1.1 1 0 0 1 1 1 1 Utp14 protein BSP_II PF05432.11 ELR20096.1 - 0.0041 16.8 6.0 0.0068 16.1 6.0 1.3 1 0 0 1 1 1 1 Bone sialoprotein II (BSP-II) RNA_pol_3_Rpc31 PF11705.8 ELR20096.1 - 0.03 14.6 6.3 0.047 13.9 6.3 1.3 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 Sigma70_ner PF04546.13 ELR20096.1 - 0.036 14.0 4.0 0.054 13.4 4.0 1.3 1 0 0 1 1 1 0 Sigma-70, non-essential region Paf1 PF03985.13 ELR20096.1 - 0.16 10.9 6.7 0.23 10.5 6.7 1.1 1 0 0 1 1 1 0 Paf1 DUF2457 PF10446.9 ELR20096.1 - 0.19 10.8 9.4 0.33 10.0 9.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Pox_Ag35 PF03286.14 ELR20096.1 - 0.26 11.0 5.3 0.56 10.0 5.3 1.5 1 0 0 1 1 1 0 Pox virus Ag35 surface protein FAM176 PF14851.6 ELR20096.1 - 0.42 10.3 4.3 0.87 9.2 4.3 1.5 1 0 0 1 1 1 0 FAM176 family CDC45 PF02724.14 ELR20096.1 - 0.6 8.3 7.2 0.84 7.9 7.2 1.1 1 0 0 1 1 1 0 CDC45-like protein Sporozoite_P67 PF05642.11 ELR20096.1 - 0.85 7.6 8.3 1.6 6.7 8.3 1.4 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Tub_N PF16322.5 ELR20096.1 - 1.7 9.0 13.3 3.2 8.1 13.3 1.4 1 0 0 1 1 1 0 Tubby N-terminal DUF4637 PF15470.6 ELR20096.1 - 2.2 8.0 9.8 4 7.1 9.8 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) PPP4R2 PF09184.11 ELR20096.1 - 2.9 7.4 9.8 4.3 6.8 9.8 1.2 1 0 0 1 1 1 0 PPP4R2 Rib_recp_KP_reg PF05104.12 ELR20096.1 - 3 8.9 15.5 6.1 7.9 15.5 1.5 1 0 0 1 1 1 0 Ribosome receptor lysine/proline rich region NOA36 PF06524.12 ELR20096.1 - 3.6 6.8 13.6 1.6 8.0 10.7 1.7 2 0 0 2 2 2 0 NOA36 protein RRN3 PF05327.11 ELR20096.1 - 5.7 5.4 6.0 8.2 4.8 6.0 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 TAF4 PF05236.14 ELR20097.1 - 1.5e-37 129.9 5.6 5.8e-37 127.9 5.6 2.1 1 1 0 1 1 1 1 Transcription initiation factor TFIID component TAF4 family Adaptin_binding PF10199.9 ELR20097.1 - 0.0029 18.2 3.6 0.0073 16.9 3.6 1.7 1 0 0 1 1 1 1 Alpha and gamma adaptin binding protein p34 DUF1844 PF08899.11 ELR20097.1 - 0.27 11.6 2.0 0.38 11.1 0.5 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF1844) SAGA-Tad1 PF12767.7 ELR20097.1 - 1.1 8.9 0.0 1.1 8.9 0.0 2.6 1 1 1 2 2 2 0 Transcriptional regulator of RNA polII, SAGA, subunit LIM PF00412.22 ELR20098.1 - 7.6e-13 48.5 3.2 1e-12 48.1 3.2 1.2 1 0 0 1 1 1 1 LIM domain zf-met PF12874.7 ELR20098.1 - 0.44 11.0 8.4 5.4 7.5 1.0 3.0 3 0 0 3 3 3 0 Zinc-finger of C2H2 type GRP PF07172.11 ELR20098.1 - 1.5 9.5 15.9 2.4 8.9 15.9 1.3 1 0 0 1 1 1 0 Glycine rich protein family Nefa_Nip30_N PF10187.9 ELR20099.1 - 2e-13 50.6 3.4 2e-13 50.6 3.4 2.7 3 0 0 3 3 3 1 N-terminal domain of NEFA-interacting nuclear protein NIP30 Med19 PF10278.9 ELR20099.1 - 0.0023 17.9 7.3 0.0042 17.0 7.3 1.4 1 0 0 1 1 1 1 Mediator of RNA pol II transcription subunit 19 DUF572 PF04502.13 ELR20099.1 - 0.0025 17.5 11.4 0.0033 17.1 11.4 1.2 1 0 0 1 1 1 1 Family of unknown function (DUF572) Ribosomal_60s PF00428.19 ELR20099.1 - 0.0099 16.4 6.3 0.0099 16.4 6.3 2.7 2 0 0 2 2 2 1 60s Acidic ribosomal protein ALAD PF00490.21 ELR20099.1 - 0.026 13.7 0.1 0.035 13.3 0.1 1.1 1 0 0 1 1 1 0 Delta-aminolevulinic acid dehydratase NOA36 PF06524.12 ELR20099.1 - 0.13 11.6 2.8 0.2 11.0 2.8 1.3 1 0 0 1 1 1 0 NOA36 protein Myc_N PF01056.18 ELR20099.1 - 0.13 12.1 8.5 0.18 11.6 8.5 1.3 1 0 0 1 1 1 0 Myc amino-terminal region Hamartin PF04388.12 ELR20099.1 - 0.29 9.8 8.7 0.33 9.6 8.7 1.1 1 0 0 1 1 1 0 Hamartin protein Mito_fiss_reg PF05308.11 ELR20099.1 - 0.71 9.9 14.3 0.52 10.4 13.0 1.6 1 1 0 1 1 1 0 Mitochondrial fission regulator Serinc PF03348.15 ELR20099.1 - 1.3 7.9 4.3 1.7 7.5 4.3 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) BUD22 PF09073.10 ELR20099.1 - 1.9 7.7 22.6 0.019 14.3 0.7 2.1 1 1 1 2 2 2 0 BUD22 Clr2 PF10383.9 ELR20099.1 - 3.1 8.6 5.2 6 7.6 5.2 1.5 1 0 0 1 1 1 0 Transcription-silencing protein Clr2 Presenilin PF01080.17 ELR20099.1 - 3.6 6.2 7.8 4.9 5.8 7.8 1.3 1 0 0 1 1 1 0 Presenilin FAM176 PF14851.6 ELR20099.1 - 6.9 6.3 9.0 0.75 9.5 3.9 2.0 2 0 0 2 2 2 0 FAM176 family DUF966 PF06136.13 ELR20099.1 - 8.6 6.0 12.6 12 5.5 12.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF966) Rap_GAP PF02145.15 ELR20100.1 - 5.2e-41 140.3 0.1 1e-40 139.3 0.1 1.5 1 0 0 1 1 1 1 Rap/ran-GAP LRR_8 PF13855.6 ELR20100.1 - 1.6e-26 91.8 33.2 7.7e-08 32.0 2.1 4.9 2 1 6 8 8 8 7 Leucine rich repeat LRR_4 PF12799.7 ELR20100.1 - 2.6e-13 49.9 14.0 3.2e-06 27.4 3.3 5.7 5 1 1 6 6 6 2 Leucine Rich repeats (2 copies) SH2 PF00017.24 ELR20100.1 - 8.8e-07 28.9 0.0 2.7e-06 27.4 0.0 1.9 1 0 0 1 1 1 1 SH2 domain LRR_1 PF00560.33 ELR20100.1 - 1.6e-05 24.8 6.7 3.9 8.4 0.0 6.1 6 0 0 6 6 6 2 Leucine Rich Repeat LRR_6 PF13516.6 ELR20100.1 - 0.0018 18.2 12.9 3.4 8.0 1.3 5.9 6 0 0 6 6 6 1 Leucine Rich repeat LRR_9 PF14580.6 ELR20100.1 - 0.0064 16.0 1.1 0.045 13.3 0.1 2.3 1 1 1 2 2 2 1 Leucine-rich repeat AP3D1 PF06375.11 ELR20100.1 - 0.08 13.2 6.9 0.16 12.2 6.9 1.4 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 CCDC53 PF10152.9 ELR20100.1 - 0.16 12.3 1.7 10 6.5 0.0 2.7 2 0 0 2 2 2 0 Subunit CCDC53 of WASH complex DUF1645 PF07816.11 ELR20100.1 - 2.6 8.6 12.0 11 6.6 0.5 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1645) C2 PF00168.30 ELR20101.1 - 7e-08 32.7 0.0 0.0033 17.7 0.0 3.4 2 1 0 2 2 2 2 C2 domain GRAM PF02893.20 ELR20101.1 - 5e-05 23.2 0.0 0.00011 22.1 0.0 1.5 1 0 0 1 1 1 1 GRAM domain Josephin PF02099.17 ELR20102.1 - 5.1e-52 176.3 0.3 7e-52 175.8 0.3 1.2 1 0 0 1 1 1 1 Josephin UIM PF02809.20 ELR20102.1 - 7.6e-07 28.6 10.8 7.2e-05 22.4 2.4 2.9 2 0 0 2 2 2 2 Ubiquitin interaction motif RAP80_UIM PF18282.1 ELR20102.1 - 0.081 12.7 0.2 12 5.7 0.0 2.4 2 0 0 2 2 2 0 RAP80 N-terminal ubiquitin interaction motif OAD_gamma PF04277.13 ELR20102.1 - 0.52 10.9 3.0 6.2 7.5 3.0 2.2 1 1 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain Guanylate_cyc PF00211.20 ELR20103.1 - 3.6e-20 72.4 7.2 1.7e-16 60.3 0.5 3.1 3 1 1 4 4 4 2 Adenylate and Guanylate cyclase catalytic domain Response_reg PF00072.24 ELR20103.1 - 4e-12 46.3 0.0 5.5e-10 39.4 0.0 2.6 2 0 0 2 2 2 2 Response regulator receiver domain TPR_2 PF07719.17 ELR20103.1 - 0.0013 18.7 0.2 0.0031 17.5 0.2 1.7 1 0 0 1 1 1 1 Tetratricopeptide repeat LIM PF00412.22 ELR20105.1 - 7e-09 35.8 9.4 1e-08 35.2 9.4 1.3 1 0 0 1 1 1 1 LIM domain HMG_box PF00505.19 ELR20106.1 - 3.1e-20 72.4 0.5 3.1e-20 72.4 0.5 1.8 2 1 0 2 2 2 1 HMG (high mobility group) box HMG_box_2 PF09011.10 ELR20106.1 - 5.8e-19 68.5 0.8 5.8e-19 68.5 0.8 1.7 2 0 0 2 2 2 1 HMG-box domain HMG_box_5 PF14887.6 ELR20106.1 - 0.0063 16.5 2.5 0.0063 16.5 2.5 2.3 1 1 1 2 2 2 1 HMG (high mobility group) box 5 Ccdc124 PF06244.12 ELR20106.1 - 0.014 16.0 3.6 0.014 16.0 3.6 2.6 1 1 1 2 2 2 0 Coiled-coil domain-containing protein 124 /Oxs1 YABBY PF04690.13 ELR20106.1 - 0.31 11.6 7.5 0.18 12.3 5.4 1.6 1 1 1 2 2 2 0 YABBY protein ATP-synt_E PF05680.12 ELR20106.1 - 7.9 6.9 11.9 0.44 10.9 3.5 2.1 2 0 0 2 2 2 0 ATP synthase E chain cwf18 PF08315.12 ELR20108.1 - 1.7e-22 80.5 9.7 3.4e-22 79.6 9.7 1.5 1 1 0 1 1 1 1 cwf18 pre-mRNA splicing factor CDC45 PF02724.14 ELR20108.1 - 0.042 12.1 7.1 0.037 12.3 7.1 1.1 1 0 0 1 1 1 0 CDC45-like protein FAM176 PF14851.6 ELR20108.1 - 0.65 9.7 7.2 1.2 8.8 7.2 1.4 1 0 0 1 1 1 0 FAM176 family RPN2_C PF18004.1 ELR20108.1 - 9.2 6.2 10.3 16 5.4 10.3 1.4 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain Polbeta PF18765.1 ELR20109.1 - 0.041 14.0 0.0 0.046 13.8 0.0 1.1 1 0 0 1 1 1 0 Polymerase beta, Nucleotidyltransferase Med17 PF10156.9 ELR20113.1 - 1.2e-07 30.9 0.3 6.6e-07 28.4 0.0 2.0 1 1 1 2 2 2 1 Subunit 17 of Mediator complex DUF3231 PF11553.8 ELR20113.1 - 0.034 13.8 0.0 0.11 12.2 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3231) FAM76 PF16046.5 ELR20113.1 - 0.063 12.6 0.9 0.1 11.9 0.9 1.2 1 0 0 1 1 1 0 FAM76 protein EF-hand_1 PF00036.32 ELR20115.1 - 0.015 14.8 0.0 5.8 6.7 0.0 2.8 2 0 0 2 2 2 0 EF hand SKICH PF17751.1 ELR20116.1 - 4.2e-12 46.5 8.4 1.7e-05 25.3 0.0 4.4 4 0 0 4 4 4 3 SKICH domain CUE PF02845.16 ELR20116.1 - 9.6e-11 41.2 2.6 4.5e-06 26.2 0.1 3.5 3 0 0 3 3 3 2 CUE domain HECW_N PF16562.5 ELR20116.1 - 3.4e-09 36.5 0.1 0.00012 21.8 0.0 3.5 3 0 0 3 3 3 2 N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2 UBA_4 PF14555.6 ELR20116.1 - 1.2e-05 25.1 0.2 2 8.3 0.0 4.5 4 0 0 4 4 4 2 UBA-like domain fn3_PAP PF17808.1 ELR20116.1 - 0.021 14.9 0.9 12 6.0 0.0 3.8 2 1 1 3 3 3 0 Fn3-like domain from Purple Acid Phosphatase TAP_C PF03943.13 ELR20116.1 - 0.043 13.5 0.1 3 7.5 0.0 3.3 3 0 0 3 3 3 0 TAP C-terminal domain DMA PF03474.14 ELR20116.1 - 0.12 12.0 0.1 26 4.5 0.0 3.3 3 0 0 3 3 3 0 DMRTA motif AP_endonuc_2 PF01261.24 ELR20116.1 - 0.33 10.4 2.9 0.68 9.3 2.9 1.6 1 0 0 1 1 1 0 Xylose isomerase-like TIM barrel Yos1 PF08571.10 ELR20117.1 - 0.0021 18.3 1.3 0.017 15.3 1.3 1.9 1 1 0 1 1 1 1 Yos1-like GTP_EFTU PF00009.27 ELR20118.1 - 5.5e-30 104.4 2.2 3.5e-28 98.5 2.2 2.4 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain IF-2 PF11987.8 ELR20118.1 - 6.2e-28 97.0 1.2 1.6e-27 95.6 1.2 1.7 1 0 0 1 1 1 1 Translation-initiation factor 2 MMR_HSR1 PF01926.23 ELR20118.1 - 7.3e-11 42.2 0.1 1.9e-10 40.8 0.1 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.10 ELR20118.1 - 1.7e-05 24.3 0.2 8.1e-05 22.1 0.2 2.0 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit RsgA_GTPase PF03193.16 ELR20118.1 - 3.7e-05 23.7 1.7 0.2 11.6 0.2 2.5 1 1 1 2 2 2 2 RsgA GTPase Arf PF00025.21 ELR20118.1 - 6.4e-05 22.5 0.1 0.00015 21.3 0.0 1.6 2 0 0 2 2 2 1 ADP-ribosylation factor family FeoB_N PF02421.18 ELR20118.1 - 0.0001 21.9 0.8 0.00028 20.4 0.8 1.8 1 1 0 1 1 1 1 Ferrous iron transport protein B Dynamin_N PF00350.23 ELR20118.1 - 0.0001 22.4 0.1 0.024 14.7 0.0 2.5 1 1 1 2 2 2 1 Dynamin family Ras PF00071.22 ELR20118.1 - 0.00022 20.9 0.1 0.00037 20.1 0.1 1.4 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR20118.1 - 0.0028 17.9 0.0 0.0048 17.1 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase PduV-EutP PF10662.9 ELR20118.1 - 0.0084 15.9 2.2 0.1 12.4 0.4 2.8 2 1 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation Ribosomal_S8 PF00410.19 ELR20118.1 - 0.028 14.4 0.1 0.8 9.7 0.0 2.4 2 0 0 2 2 2 0 Ribosomal protein S8 HNOBA PF07701.14 ELR20118.1 - 0.13 11.7 0.0 0.23 10.9 0.0 1.4 1 0 0 1 1 1 0 Heme NO binding associated Peptidase_C1 PF00112.23 ELR20119.1 - 7.8e-80 268.0 0.9 7.8e-80 268.0 0.9 1.9 2 0 0 2 2 2 1 Papain family cysteine protease Inhibitor_I29 PF08246.12 ELR20119.1 - 4.7e-14 52.6 4.8 8e-14 51.8 4.8 1.4 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Peptidase_C1_2 PF03051.15 ELR20119.1 - 0.00023 20.1 2.9 0.0015 17.4 0.4 2.1 2 0 0 2 2 2 2 Peptidase C1-like family SelP_N PF04592.14 ELR20119.1 - 7.8 5.8 13.8 13 5.1 13.8 1.3 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Amino_oxidase PF01593.24 ELR20120.1 - 1.8e-36 126.4 0.0 2.1e-36 126.2 0.0 1.1 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 ELR20120.1 - 2.4e-11 43.7 0.1 1.2e-10 41.5 0.1 2.1 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.14 ELR20120.1 - 0.00054 18.8 0.1 0.055 12.2 0.0 2.2 2 0 0 2 2 2 2 HI0933-like protein DAO PF01266.24 ELR20120.1 - 0.0056 16.3 1.8 0.012 15.2 1.8 1.8 1 1 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 ELR20120.1 - 0.018 14.3 0.3 0.84 8.8 0.0 2.2 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase MCRA PF06100.11 ELR20120.1 - 0.02 13.7 0.0 0.032 13.1 0.0 1.2 1 0 0 1 1 1 0 MCRA family NAD_binding_9 PF13454.6 ELR20120.1 - 0.044 13.8 0.2 1.2 9.1 0.0 2.3 2 0 0 2 2 2 0 FAD-NAD(P)-binding Pyr_redox PF00070.27 ELR20120.1 - 0.088 13.4 0.3 19 5.9 0.0 2.5 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase LMBR1 PF04791.16 ELR20121.1 - 2.5e-115 386.3 18.4 2.5e-115 386.3 18.4 1.3 2 0 0 2 2 2 1 LMBR1-like membrane protein SUKH_6 PF14568.6 ELR20122.1 - 8.2e-17 61.8 0.0 2e-16 60.5 0.0 1.7 1 0 0 1 1 1 1 SMI1-KNR4 cell-wall SMI1_KNR4 PF09346.10 ELR20122.1 - 7.1e-16 58.8 0.0 1.3e-15 57.9 0.0 1.5 1 0 0 1 1 1 1 SMI1 / KNR4 family (SUKH-1) SUKH_5 PF14567.6 ELR20122.1 - 3.5e-05 23.6 0.0 0.015 15.1 0.0 2.3 1 1 1 2 2 2 2 SMI1-KNR4 cell-wall Tub_N PF16322.5 ELR20122.1 - 6.4 7.1 13.3 8.8 6.7 13.3 1.2 1 0 0 1 1 1 0 Tubby N-terminal DEAD PF00270.29 ELR20123.1 - 2.4e-48 164.2 0.1 4.8e-48 163.2 0.1 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ELR20123.1 - 1.6e-31 108.9 0.3 7.1e-29 100.4 0.0 2.9 3 0 0 3 3 3 2 Helicase conserved C-terminal domain DpnI_C PF17726.1 ELR20123.1 - 0.069 13.3 0.1 0.25 11.5 0.1 1.9 1 0 0 1 1 1 0 Dam-replacing HTH domain AAA_22 PF13401.6 ELR20123.1 - 0.14 12.4 0.9 0.53 10.6 0.5 2.3 2 1 0 2 2 2 0 AAA domain Zip PF02535.22 ELR20123.1 - 0.64 9.2 4.3 0.24 10.6 1.7 1.5 1 1 0 1 1 1 0 ZIP Zinc transporter DUF3408 PF11888.8 ELR20123.1 - 1.5 9.0 16.3 0.54 10.4 9.9 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3408) VDE PF07137.11 ELR20124.1 - 0.0019 17.8 7.6 0.0026 17.3 7.6 1.2 1 0 0 1 1 1 1 VDE lipocalin domain VDE PF07137.11 ELR20125.1 - 0.00013 21.6 15.6 0.00013 21.6 15.6 2.1 2 0 0 2 2 2 1 VDE lipocalin domain Pup_ligase PF03136.15 ELR20125.1 - 0.061 12.3 0.1 0.073 12.1 0.1 1.0 1 0 0 1 1 1 0 Pup-ligase protein Peptidase_C34 PF05413.11 ELR20125.1 - 8.8 6.7 16.5 1.1 9.6 2.8 2.3 2 0 0 2 2 2 0 Putative closterovirus papain-like endopeptidase Aconitase PF00330.20 ELR20127.1 - 4.2e-155 517.3 0.1 5.3e-155 516.9 0.1 1.1 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 ELR20127.1 - 1.4e-36 125.7 0.1 1.2e-28 100.0 0.0 2.4 2 0 0 2 2 2 2 Aconitase C-terminal domain PH PF00169.29 ELR20128.1 - 1.2e-12 48.2 0.5 3.7e-12 46.7 0.1 2.1 1 1 1 2 2 2 1 PH domain PH_3 PF14593.6 ELR20128.1 - 3.6e-05 23.8 0.6 0.00013 22.0 0.1 2.1 1 1 1 2 2 2 1 PH domain PH_11 PF15413.6 ELR20128.1 - 0.00043 20.7 0.3 0.0015 19.0 0.3 2.1 1 1 0 1 1 1 1 Pleckstrin homology domain Mst1_SARAH PF11629.8 ELR20128.1 - 0.0017 18.4 3.4 0.0038 17.3 3.4 1.6 1 0 0 1 1 1 1 C terminal SARAH domain of Mst1 TFIIA PF03153.13 ELR20128.1 - 0.0036 17.4 5.4 0.0044 17.1 5.4 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit CDC45 PF02724.14 ELR20128.1 - 0.44 8.8 16.8 0.68 8.2 16.8 1.3 1 0 0 1 1 1 0 CDC45-like protein Nore1-SARAH PF16517.5 ELR20128.1 - 4.5 7.2 8.1 0.3 11.0 2.6 1.9 2 0 0 2 2 2 0 Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain Neur_chan_memb PF02932.16 ELR20128.1 - 6.5 6.7 7.5 11 6.0 7.5 1.4 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region MutL_C PF08676.11 ELR20129.1 - 7.3e-35 119.9 0.1 1.2e-34 119.1 0.1 1.4 1 0 0 1 1 1 1 MutL C terminal dimerisation domain DNA_mis_repair PF01119.19 ELR20129.1 - 2.4e-21 75.6 0.0 4.8e-21 74.6 0.0 1.6 1 0 0 1 1 1 1 DNA mismatch repair protein, C-terminal domain HATPase_c_3 PF13589.6 ELR20129.1 - 4.1e-12 46.1 0.1 2.1e-11 43.8 0.0 2.3 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 ELR20129.1 - 8.6e-06 26.2 0.0 2.1e-05 25.0 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Glyco_hydro_cc PF11790.8 ELR20130.1 - 0.0063 16.1 0.0 0.011 15.3 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase catalytic core R3H PF01424.22 ELR20131.1 - 4.3e-14 52.2 0.3 1e-13 51.0 0.3 1.7 1 0 0 1 1 1 1 R3H domain SAM_MT PF04445.13 ELR20132.1 - 3.3e-65 219.7 0.7 4.7e-65 219.2 0.7 1.2 1 0 0 1 1 1 1 Putative SAM-dependent methyltransferase Cons_hypoth95 PF03602.15 ELR20132.1 - 0.0018 18.0 0.0 0.0032 17.1 0.0 1.5 1 0 0 1 1 1 1 Conserved hypothetical protein 95 YL1 PF05764.13 ELR20132.1 - 0.0068 16.5 10.5 0.012 15.7 10.5 1.4 1 0 0 1 1 1 1 YL1 nuclear protein CDC45 PF02724.14 ELR20132.1 - 0.024 13.0 6.4 0.031 12.6 6.4 1.1 1 0 0 1 1 1 0 CDC45-like protein Nop14 PF04147.12 ELR20132.1 - 0.15 10.2 11.2 0.22 9.7 11.2 1.3 1 0 0 1 1 1 0 Nop14-like family TFB6 PF17110.5 ELR20132.1 - 0.53 10.0 7.0 21 4.8 0.0 2.3 2 0 0 2 2 2 0 Subunit 11 of the general transcription factor TFIIH Merozoite_SPAM PF07133.11 ELR20132.1 - 3 7.8 21.9 4.3 7.3 21.9 1.1 1 0 0 1 1 1 0 Merozoite surface protein (SPAM) SDA1 PF05285.12 ELR20132.1 - 4.2 6.7 14.5 6.2 6.1 14.5 1.2 1 0 0 1 1 1 0 SDA1 RRN3 PF05327.11 ELR20132.1 - 4.3 5.8 8.7 6 5.3 8.7 1.2 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 eIF3_subunit PF08597.10 ELR20132.1 - 5.7 6.8 16.5 9.1 6.1 16.5 1.3 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit 3Beta_HSD PF01073.19 ELR20134.1 - 1.1e-76 257.6 0.0 1.3e-76 257.3 0.0 1.0 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 ELR20134.1 - 1.5e-33 116.3 0.0 2.2e-33 115.7 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 ELR20134.1 - 4.6e-16 59.3 0.0 6.9e-16 58.7 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding NAD_binding_4 PF07993.12 ELR20134.1 - 2e-15 56.7 0.0 1.6e-11 43.8 0.0 2.3 1 1 1 2 2 2 2 Male sterility protein GDP_Man_Dehyd PF16363.5 ELR20134.1 - 2.5e-13 50.2 0.0 1.8e-09 37.5 0.0 2.5 2 1 0 2 2 2 2 GDP-mannose 4,6 dehydratase RmlD_sub_bind PF04321.17 ELR20134.1 - 1.4e-08 34.2 0.0 2.3e-08 33.5 0.0 1.3 1 0 0 1 1 1 1 RmlD substrate binding domain Polysacc_synt_2 PF02719.15 ELR20134.1 - 0.00011 21.4 0.1 0.0011 18.2 0.1 2.0 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein KR PF08659.10 ELR20134.1 - 0.00025 21.0 0.3 0.027 14.4 0.3 2.6 1 1 0 1 1 1 1 KR domain AP_endonuc_2 PF01261.24 ELR20134.1 - 0.02 14.4 0.0 0.03 13.8 0.0 1.3 1 0 0 1 1 1 0 Xylose isomerase-like TIM barrel NmrA PF05368.13 ELR20134.1 - 0.05 13.1 0.0 0.16 11.5 0.0 1.8 1 1 0 1 1 1 0 NmrA-like family TrkA_N PF02254.18 ELR20134.1 - 0.15 12.3 0.0 0.29 11.4 0.0 1.4 1 0 0 1 1 1 0 TrkA-N domain PseudoU_synth_2 PF00849.22 ELR20135.1 - 0.0031 17.6 0.0 0.0049 17.0 0.0 1.3 1 0 0 1 1 1 1 RNA pseudouridylate synthase PseudoU_synth_2 PF00849.22 ELR20136.1 - 0.00032 20.8 0.0 0.00034 20.7 0.0 1.2 1 0 0 1 1 1 1 RNA pseudouridylate synthase MnmE_helical PF12631.7 ELR20137.1 - 2.7e-57 194.3 0.7 3.6e-57 193.9 0.7 1.2 1 0 0 1 1 1 1 MnmE helical domain TrmE_N PF10396.9 ELR20137.1 - 6e-35 120.0 0.0 1.4e-34 118.9 0.0 1.6 1 0 0 1 1 1 1 GTP-binding protein TrmE N-terminus MMR_HSR1 PF01926.23 ELR20137.1 - 7.5e-20 71.1 0.0 3.8e-19 68.9 0.0 2.1 2 0 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 ELR20137.1 - 1.7e-08 34.1 0.0 3e-08 33.4 0.0 1.4 1 0 0 1 1 1 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 ELR20137.1 - 3.3e-06 27.1 0.0 0.1 12.5 0.0 2.7 2 0 0 2 2 2 2 RsgA GTPase Dynamin_N PF00350.23 ELR20137.1 - 6e-06 26.4 0.0 2.4e-05 24.5 0.0 2.2 1 1 0 1 1 1 1 Dynamin family AAA_18 PF13238.6 ELR20137.1 - 0.00024 21.6 0.1 0.55 10.8 0.0 3.2 2 1 0 2 2 2 2 AAA domain ABC_tran PF00005.27 ELR20137.1 - 0.00039 20.9 0.2 0.0064 17.0 0.0 2.4 2 0 0 2 2 2 1 ABC transporter AAA_16 PF13191.6 ELR20137.1 - 0.012 16.0 0.9 0.071 13.5 0.2 2.7 1 1 1 2 2 2 0 AAA ATPase domain AAA_22 PF13401.6 ELR20137.1 - 0.013 15.7 0.0 0.63 10.3 0.0 2.5 2 0 0 2 2 2 0 AAA domain AAA_28 PF13521.6 ELR20137.1 - 0.022 15.0 0.0 0.056 13.7 0.0 1.7 1 0 0 1 1 1 0 AAA domain MMR_HSR1_Xtn PF16897.5 ELR20137.1 - 0.057 13.4 0.2 0.26 11.3 0.0 2.1 2 0 0 2 2 2 0 C-terminal region of MMR_HSR1 domain TniB PF05621.11 ELR20137.1 - 0.07 12.5 0.0 0.14 11.5 0.0 1.5 1 0 0 1 1 1 0 Bacterial TniB protein cobW PF02492.19 ELR20137.1 - 0.073 12.6 0.0 7.3 6.1 0.0 2.5 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Guanylate_kin PF00625.21 ELR20137.1 - 0.16 11.7 0.0 0.3 10.7 0.0 1.4 1 0 0 1 1 1 0 Guanylate kinase Cwf_Cwc_15 PF04889.12 ELR20138.1 - 0.00089 19.1 9.0 0.0011 18.7 9.0 1.2 1 0 0 1 1 1 1 Cwf15/Cwc15 cell cycle control protein SLT_L PF14718.6 ELR20138.1 - 0.073 13.2 1.4 1.3 9.2 0.2 2.8 3 0 0 3 3 3 0 Soluble lytic murein transglycosylase L domain LPD24 PF18839.1 ELR20138.1 - 0.082 13.2 1.9 0.17 12.2 1.9 1.5 1 0 0 1 1 1 0 Large polyvalent protein associated domain 24 Spt5_N PF11942.8 ELR20138.1 - 0.24 12.4 13.0 0.47 11.5 13.0 1.5 1 0 0 1 1 1 0 Spt5 transcription elongation factor, acidic N-terminal TPD52 PF04201.15 ELR20138.1 - 0.71 9.5 5.8 1.3 8.6 5.8 1.4 1 0 0 1 1 1 0 Tumour protein D52 family LRR19-TM PF15176.6 ELR20138.1 - 1 9.4 7.6 1.4 9.0 4.7 2.5 1 1 0 1 1 1 0 Leucine-rich repeat family 19 TM domain CDC45 PF02724.14 ELR20138.1 - 2.4 6.4 12.8 3 6.0 12.8 1.1 1 0 0 1 1 1 0 CDC45-like protein YqfQ PF14181.6 ELR20138.1 - 6.6 6.9 8.1 10 6.3 8.1 1.3 1 0 0 1 1 1 0 YqfQ-like protein DNA_pol_phi PF04931.13 ELR20138.1 - 7 4.6 17.0 3.9 5.5 13.2 1.9 2 0 0 2 2 2 0 DNA polymerase phi Zip PF02535.22 ELR20138.1 - 8 5.6 8.7 12 5.0 8.7 1.4 1 0 0 1 1 1 0 ZIP Zinc transporter DUF1768 PF08719.11 ELR20139.1 - 7.5e-18 65.3 0.0 1.7e-17 64.1 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1768) Caldesmon PF02029.15 ELR20139.1 - 0.33 9.7 63.6 0.0053 15.6 15.2 3.1 3 0 0 3 3 3 0 Caldesmon LMBR1 PF04791.16 ELR20139.1 - 1.8 7.4 4.2 2.8 6.7 4.2 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein SMN PF06003.12 ELR20140.1 - 0.00016 21.0 11.5 0.00016 21.0 11.5 2.6 2 1 1 3 3 3 1 Survival motor neuron protein (SMN) Methyltransf_25 PF13649.6 ELR20141.1 - 6.7e-07 29.9 0.0 1.1e-05 26.0 0.0 2.2 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 ELR20141.1 - 1.8e-05 24.6 0.0 0.0007 19.5 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ELR20141.1 - 0.00023 21.8 0.0 0.023 15.3 0.0 2.6 1 1 1 2 2 2 1 Methyltransferase domain DREV PF05219.12 ELR20141.1 - 0.00029 20.0 0.0 0.00039 19.6 0.0 1.2 1 0 0 1 1 1 1 DREV methyltransferase Presenilin PF01080.17 ELR20141.1 - 0.00048 19.0 0.4 0.00068 18.5 0.4 1.2 1 0 0 1 1 1 1 Presenilin Methyltransf_12 PF08242.12 ELR20141.1 - 0.0011 19.6 0.0 0.019 15.7 0.0 2.5 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 ELR20141.1 - 0.0051 16.6 0.0 0.014 15.2 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain TRM13 PF05206.14 ELR20141.1 - 0.006 16.1 4.9 0.011 15.2 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase TRM13 Methyltransf_32 PF13679.6 ELR20141.1 - 0.027 14.5 3.7 0.79 9.7 0.0 2.2 2 0 0 2 2 2 0 Methyltransferase domain RrnaAD PF00398.20 ELR20141.1 - 0.032 13.3 0.0 0.043 12.9 0.0 1.2 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase MTS PF05175.14 ELR20141.1 - 0.049 13.2 0.0 0.15 11.6 0.0 1.8 1 1 1 2 2 2 0 Methyltransferase small domain RNA_pol_Rpc4 PF05132.14 ELR20141.1 - 0.052 14.0 1.5 0.075 13.5 1.5 1.2 1 0 0 1 1 1 0 RNA polymerase III RPC4 DUF913 PF06025.12 ELR20141.1 - 0.18 10.7 1.7 0.24 10.4 1.7 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) RR_TM4-6 PF06459.12 ELR20141.1 - 0.22 11.3 7.8 0.3 10.9 7.8 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 NPR3 PF03666.13 ELR20141.1 - 0.63 8.8 7.9 0.92 8.2 7.9 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 DUF5427 PF10310.9 ELR20141.1 - 0.68 8.8 12.0 0.94 8.4 12.0 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5427) Spore_coat_CotO PF14153.6 ELR20141.1 - 0.79 9.6 9.7 1.3 9.0 9.7 1.2 1 0 0 1 1 1 0 Spore coat protein CotO DUF4834 PF16118.5 ELR20141.1 - 1.7 9.6 9.3 4.1 8.4 9.3 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) PBP_sp32 PF07222.12 ELR20141.1 - 2.1 7.8 10.4 3.3 7.1 10.4 1.2 1 0 0 1 1 1 0 Proacrosin binding protein sp32 Zip PF02535.22 ELR20141.1 - 3.8 6.6 5.8 5.7 6.1 5.8 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter PAF PF15715.5 ELR20141.1 - 4.9 7.7 14.1 8.4 7.0 14.1 1.3 1 0 0 1 1 1 0 PCNA-associated factor histone like domain DUF4746 PF15928.5 ELR20141.1 - 5.4 6.4 15.0 7.9 5.8 15.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Sec62 PF03839.16 ELR20141.1 - 5.8 6.4 6.8 8.7 5.8 6.8 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 NOA36 PF06524.12 ELR20141.1 - 7.7 5.7 10.3 11 5.3 10.3 1.1 1 0 0 1 1 1 0 NOA36 protein PUNUT PF16913.5 ELR20142.1 - 4.7e-05 22.8 0.7 0.00012 21.4 0.7 1.5 1 1 0 1 1 1 1 Purine nucleobase transmembrane transport EamA PF00892.20 ELR20142.1 - 0.011 15.9 28.4 0.013 15.7 4.4 3.5 3 1 0 3 3 3 0 EamA-like transporter family Cgr1 PF03879.14 ELR20143.1 - 6.7e-15 55.4 27.7 6.7e-15 55.4 27.7 1.7 2 0 0 2 2 2 1 Cgr1 family PH_4 PF15404.6 ELR20143.1 - 0.33 10.7 11.3 0.19 11.5 9.5 1.4 1 1 0 1 1 1 0 Pleckstrin homology domain U79_P34 PF03064.16 ELR20143.1 - 0.96 8.8 15.9 1.2 8.5 15.9 1.1 1 0 0 1 1 1 0 HSV U79 / HCMV P34 PPI_Ypi1 PF07491.11 ELR20144.1 - 2.9e-21 75.0 4.4 2.9e-21 75.0 4.4 1.9 2 1 0 2 2 2 1 Protein phosphatase inhibitor Treacle PF03546.14 ELR20144.1 - 0.098 11.5 0.5 0.12 11.2 0.5 1.1 1 0 0 1 1 1 0 Treacher Collins syndrome protein Treacle SelP_N PF04592.14 ELR20144.1 - 0.37 10.2 13.8 0.43 10.0 13.8 1.1 1 0 0 1 1 1 0 Selenoprotein P, N terminal region LPD15 PF18828.1 ELR20144.1 - 1.4 8.8 3.8 2.3 8.1 0.9 2.0 1 1 1 2 2 2 0 Large polyvalent-protein-associated domain 15 Innate_immun PF12782.7 ELR20144.1 - 4.6 6.7 15.2 5.8 6.3 15.2 1.1 1 0 0 1 1 1 0 Invertebrate innate immunity transcript family NOT2_3_5 PF04153.18 ELR20145.1 - 6.5e-44 149.2 14.9 6.5e-44 149.2 14.9 3.1 3 0 0 3 3 3 1 NOT2 / NOT3 / NOT5 family Not3 PF04065.15 ELR20145.1 - 1e-39 136.3 8.6 1e-39 136.3 8.6 1.7 2 0 0 2 2 2 1 Not1 N-terminal domain, CCR4-Not complex component Fmp27_WPPW PF10359.9 ELR20145.1 - 6.2e-05 22.0 0.2 6.2e-05 22.0 0.2 1.8 2 0 0 2 2 2 1 RNA pol II promoter Fmp27 protein domain FANCI_S3 PF14677.6 ELR20146.1 - 0.067 12.9 0.2 0.12 12.1 0.2 1.3 1 0 0 1 1 1 0 FANCI solenoid 3 DUF4413 PF14372.6 ELR20146.1 - 0.083 13.3 0.1 0.14 12.5 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4413) DUF4611 PF15387.6 ELR20146.1 - 2.3 8.5 9.8 2.4 8.4 6.4 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4611) NAD_binding_4 PF07993.12 ELR20147.1 - 1.1e-33 116.5 0.0 1.7e-33 115.9 0.0 1.3 1 0 0 1 1 1 1 Male sterility protein AMP-binding PF00501.28 ELR20147.1 - 8.4e-25 87.2 1.5 5.8e-15 54.8 0.1 2.6 1 1 1 2 2 2 2 AMP-binding enzyme Epimerase PF01370.21 ELR20147.1 - 5.8e-06 25.9 0.0 1.9e-05 24.3 0.0 1.9 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family PP-binding PF00550.25 ELR20147.1 - 0.021 15.2 0.0 0.061 13.7 0.0 1.8 1 0 0 1 1 1 0 Phosphopantetheine attachment site MBD PF01429.19 ELR20148.1 - 1.3e-13 50.4 0.0 3.1e-13 49.2 0.0 1.6 1 0 0 1 1 1 1 Methyl-CpG binding domain Pre-SET PF05033.16 ELR20148.1 - 5.6e-13 49.5 10.6 1.5e-12 48.1 10.6 1.7 1 0 0 1 1 1 1 Pre-SET motif SET PF00856.28 ELR20148.1 - 1.5e-07 32.0 4.5 1.5e-07 32.0 4.5 2.9 2 2 0 2 2 2 1 SET domain GAGA_bind PF06217.12 ELR20149.1 - 0.031 14.6 5.2 0.031 14.5 5.2 1.1 1 0 0 1 1 1 0 GAGA binding protein-like family RR_TM4-6 PF06459.12 ELR20149.1 - 0.79 9.5 10.5 0.78 9.5 10.5 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 CDC45 PF02724.14 ELR20149.1 - 5.8 5.1 16.5 6.6 4.9 16.5 1.1 1 0 0 1 1 1 0 CDC45-like protein SAPS PF04499.15 ELR20149.1 - 6.3 5.5 11.2 7 5.3 11.2 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein RhoGAP PF00620.27 ELR20151.1 - 1.3e-20 73.8 0.0 2.3e-20 73.0 0.0 1.4 1 0 0 1 1 1 1 RhoGAP domain GILT PF03227.16 ELR20152.1 - 7e-12 45.5 0.2 1.1e-11 44.9 0.2 1.3 1 0 0 1 1 1 1 Gamma interferon inducible lysosomal thiol reductase (GILT) Thioredoxin_4 PF13462.6 ELR20152.1 - 2.7e-05 24.4 0.0 0.063 13.4 0.0 2.1 2 0 0 2 2 2 2 Thioredoxin DSBA PF01323.20 ELR20152.1 - 0.0031 17.3 0.0 0.04 13.7 0.0 2.0 2 0 0 2 2 2 1 DSBA-like thioredoxin domain Thioredoxin_2 PF13098.6 ELR20152.1 - 0.0091 16.4 0.0 2.7 8.5 0.0 2.1 2 0 0 2 2 2 2 Thioredoxin-like domain Thioredoxin_3 PF13192.6 ELR20152.1 - 0.0093 16.0 0.0 0.52 10.4 0.0 2.4 2 0 0 2 2 2 1 Thioredoxin domain Peptidase_S28 PF05577.12 ELR20153.1 - 1.7e-85 287.5 0.0 2e-85 287.2 0.0 1.1 1 0 0 1 1 1 1 Serine carboxypeptidase S28 Hydrolase_4 PF12146.8 ELR20153.1 - 2.9e-06 26.7 0.0 4.7e-06 26.0 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Peptidase_S9 PF00326.21 ELR20153.1 - 7.3e-05 22.3 0.0 0.0002 20.9 0.0 1.7 2 0 0 2 2 2 1 Prolyl oligopeptidase family Abhydrolase_1 PF00561.20 ELR20153.1 - 0.00056 19.6 0.1 0.00096 18.9 0.1 1.5 1 0 0 1 1 1 1 alpha/beta hydrolase fold DUF2920 PF11144.8 ELR20153.1 - 0.0019 17.4 0.0 0.0029 16.9 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2920) Abhydrolase_6 PF12697.7 ELR20153.1 - 0.0032 18.1 1.8 0.0032 18.1 1.8 2.6 2 1 0 3 3 3 1 Alpha/beta hydrolase family Peptidase_S37 PF05576.11 ELR20153.1 - 0.043 12.5 0.1 0.066 11.9 0.1 1.2 1 0 0 1 1 1 0 PS-10 peptidase S37 HSDR_N_2 PF13588.6 ELR20155.1 - 8.6e-05 22.5 0.0 0.00016 21.6 0.0 1.4 1 0 0 1 1 1 1 Type I restriction enzyme R protein N terminus (HSDR_N) HSDR_N PF04313.14 ELR20155.1 - 0.1 12.5 0.0 0.18 11.7 0.0 1.4 1 0 0 1 1 1 0 Type I restriction enzyme R protein N terminus (HSDR_N) SDA1 PF05285.12 ELR20155.1 - 6.7 6.0 8.4 9.8 5.5 8.4 1.1 1 0 0 1 1 1 0 SDA1 Exo_endo_phos PF03372.23 ELR20156.1 - 1.4e-07 31.3 0.1 3.4e-07 30.0 0.1 1.7 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Cwf_Cwc_15 PF04889.12 ELR20156.1 - 0.0079 16.0 16.5 0.013 15.3 16.5 1.3 1 0 0 1 1 1 1 Cwf15/Cwc15 cell cycle control protein AP3D1 PF06375.11 ELR20156.1 - 0.29 11.4 9.8 0.13 12.5 7.5 1.6 2 0 0 2 2 2 0 AP-3 complex subunit delta-1 DNA_pol_phi PF04931.13 ELR20156.1 - 7.5 4.5 11.1 11 3.9 11.1 1.2 1 0 0 1 1 1 0 DNA polymerase phi NFACT-R_1 PF05670.13 ELR20157.1 - 6e-43 145.9 0.0 1.2e-42 145.0 0.0 1.5 1 0 0 1 1 1 1 NFACT protein RNA binding domain TP53IP5 PF15331.6 ELR20157.1 - 0.17 12.0 6.8 0.23 11.6 6.8 1.1 1 0 0 1 1 1 0 Cellular tumour antigen p53-inducible 5 Pkinase_Tyr PF07714.17 ELR20158.1 - 8.8e-32 110.4 1.5 5.3e-12 45.6 0.0 3.4 2 1 1 3 3 3 3 Protein tyrosine kinase Pkinase PF00069.25 ELR20158.1 - 1.1e-22 80.7 0.7 1.2e-11 44.5 0.0 3.4 2 1 1 3 3 3 3 Protein kinase domain LRR_8 PF13855.6 ELR20158.1 - 1.1e-14 53.9 27.7 1.3e-06 28.0 4.3 4.0 2 1 3 5 5 5 4 Leucine rich repeat LRR_4 PF12799.7 ELR20158.1 - 3.6e-08 33.6 14.1 0.00073 19.9 2.4 3.7 3 0 0 3 3 3 3 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 ELR20158.1 - 0.0055 16.7 18.6 2.5 8.4 0.1 6.3 6 0 0 6 6 6 3 Leucine Rich repeat LRR_9 PF14580.6 ELR20158.1 - 0.23 10.9 0.7 0.61 9.6 0.7 1.6 1 0 0 1 1 1 0 Leucine-rich repeat LRR_1 PF00560.33 ELR20158.1 - 7.3 7.6 17.9 20 6.2 0.4 5.6 5 0 0 5 5 5 0 Leucine Rich Repeat Herpes_pp85 PF04637.12 ELR20158.1 - 7.7 4.8 7.5 16 3.8 7.5 1.4 1 0 0 1 1 1 0 Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25) WASH_WAHD PF11945.8 ELR20159.1 - 6.9e-16 58.6 0.0 2.2e-15 57.0 0.0 1.7 1 1 0 1 1 1 1 WAHD domain of WASH complex Lipoprotein_16 PF03923.13 ELR20159.1 - 0.093 12.4 0.1 0.45 10.2 0.0 1.9 2 0 0 2 2 2 0 Uncharacterized lipoprotein MFS_1_like PF12832.7 ELR20160.1 - 3.7e-76 256.5 13.3 5.6e-76 255.9 13.3 1.1 1 0 0 1 1 1 1 MFS_1 like family MFS_1 PF07690.16 ELR20160.1 - 3.2e-26 92.1 30.5 8.2e-23 80.9 24.5 2.5 1 1 1 2 2 2 2 Major Facilitator Superfamily LacY_symp PF01306.19 ELR20160.1 - 7.5e-07 28.3 16.0 3e-06 26.3 7.8 2.5 2 0 0 2 2 2 2 LacY proton/sugar symporter MFS_2 PF13347.6 ELR20160.1 - 0.026 13.1 26.1 0.17 10.4 9.1 3.2 4 0 0 4 4 4 0 MFS/sugar transport protein DUF3500 PF12006.8 ELR20160.1 - 0.13 11.7 0.1 0.22 11.0 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3500) DUF2207 PF09972.9 ELR20160.1 - 0.26 10.0 0.0 0.26 10.0 0.0 3.6 3 1 0 3 3 3 0 Predicted membrane protein (DUF2207) ELO PF01151.18 ELR20161.1 - 1.8e-54 184.9 25.6 2.3e-54 184.6 25.6 1.0 1 0 0 1 1 1 1 GNS1/SUR4 family Pkinase_Tyr PF07714.17 ELR20162.1 - 7.1e-57 192.6 0.0 9.5e-57 192.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Ank_2 PF12796.7 ELR20162.1 - 4.6e-46 155.3 4.6 4.8e-17 62.3 0.3 4.0 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Pkinase PF00069.25 ELR20162.1 - 5.5e-46 157.1 0.0 9.1e-46 156.4 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Ank_4 PF13637.6 ELR20162.1 - 5.4e-42 141.6 9.6 6.1e-09 36.3 0.1 5.6 1 1 5 6 6 6 6 Ankyrin repeats (many copies) Ank_5 PF13857.6 ELR20162.1 - 6.3e-35 118.8 11.7 2e-09 37.5 0.1 5.3 1 1 5 6 6 6 5 Ankyrin repeats (many copies) Ank PF00023.30 ELR20162.1 - 6.9e-29 99.0 6.9 2.4e-05 24.6 0.0 6.9 5 1 1 6 6 6 5 Ankyrin repeat Ank_3 PF13606.6 ELR20162.1 - 3.9e-27 91.3 0.9 0.0021 18.4 0.0 7.4 7 0 0 7 7 7 5 Ankyrin repeat SAM_2 PF07647.17 ELR20162.1 - 5e-17 61.8 0.0 1.3e-16 60.4 0.0 1.8 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 ELR20162.1 - 1.6e-12 47.7 0.0 3.4e-12 46.6 0.0 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) APH PF01636.23 ELR20162.1 - 0.021 14.8 0.1 0.079 12.9 0.1 1.9 2 0 0 2 2 2 0 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 ELR20162.1 - 0.19 10.5 0.0 0.3 9.8 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase Haspin_kinase PF12330.8 ELR20162.1 - 0.27 10.1 0.0 0.54 9.1 0.0 1.4 1 0 0 1 1 1 0 Haspin like kinase domain GST_C_3 PF14497.6 ELR20163.1 - 3.7e-18 65.5 0.0 7.6e-18 64.5 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 ELR20163.1 - 8.3e-08 32.3 0.0 1.8e-07 31.3 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 ELR20163.1 - 0.00013 22.2 0.0 0.00026 21.3 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 ELR20163.1 - 0.0045 17.0 0.1 0.0091 16.0 0.1 1.7 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 ELR20163.1 - 0.032 14.7 0.0 0.065 13.7 0.0 1.5 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain Presenilin PF01080.17 ELR20163.1 - 3.2 6.4 10.6 4.4 6.0 10.6 1.1 1 0 0 1 1 1 0 Presenilin Macoilin PF09726.9 ELR20163.1 - 6.5 5.2 12.2 9.4 4.7 12.2 1.1 1 0 0 1 1 1 0 Macoilin family DIL PF01843.19 ELR20164.1 - 6.5e-22 77.8 0.9 2.1e-21 76.1 0.9 1.9 1 0 0 1 1 1 1 DIL domain NT-C2 PF10358.9 ELR20164.1 - 5.1e-19 68.4 2.2 2.6e-18 66.1 2.1 2.1 2 0 0 2 2 2 1 N-terminal C2 in EEIG1 and EHBP1 proteins Fez1 PF06818.15 ELR20164.1 - 6.6 7.1 33.0 3.6 8.0 20.2 2.6 1 1 1 2 2 2 0 Fez1 Seryl_tRNA_N PF02403.22 ELR20164.1 - 7.5 6.8 35.2 1.5 9.1 9.5 3.7 3 1 1 4 4 4 0 Seryl-tRNA synthetase N-terminal domain BTB PF00651.31 ELR20165.1 - 7.3e-36 122.8 0.2 5e-20 71.8 0.0 3.2 2 1 1 3 3 3 2 BTB/POZ domain LRR_8 PF13855.6 ELR20165.1 - 1.2e-19 69.8 21.8 5.4e-11 42.1 0.7 3.3 2 1 2 4 4 4 3 Leucine rich repeat LRR_4 PF12799.7 ELR20165.1 - 1.5e-17 63.4 19.0 6.1e-07 29.7 2.3 4.5 2 2 2 4 4 4 4 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 ELR20165.1 - 3.7e-05 23.3 2.6 0.0013 18.2 0.1 2.4 2 0 0 2 2 2 2 Leucine-rich repeat LRR_1 PF00560.33 ELR20165.1 - 0.023 15.2 12.2 39 5.3 0.1 5.8 4 1 0 4 4 4 0 Leucine Rich Repeat Lectin_legB PF00139.19 ELR20165.1 - 0.04 13.4 0.0 0.13 11.8 0.0 1.7 2 0 0 2 2 2 0 Legume lectin domain LRR_6 PF13516.6 ELR20165.1 - 0.042 13.9 16.2 4.2 7.7 0.1 5.9 6 0 0 6 6 6 0 Leucine Rich repeat Pex14_N PF04695.13 ELR20165.1 - 2.9 8.5 8.6 5.3 7.7 8.6 1.3 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region 7tm_1 PF00001.21 ELR20166.1 - 1.2e-15 57.6 5.3 1.5e-15 57.3 5.3 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Git3 PF11710.8 ELR20166.1 - 2.7e-11 43.6 11.8 7e-11 42.3 11.8 1.7 1 1 0 1 1 1 1 G protein-coupled glucose receptor regulating Gpa2 Dicty_CAR PF05462.11 ELR20166.1 - 1.4e-05 24.4 8.9 2.2e-05 23.7 8.9 1.3 1 0 0 1 1 1 1 Slime mold cyclic AMP receptor GPR_Gpa2_C PF11970.8 ELR20166.1 - 0.00038 20.5 2.3 0.00038 20.5 2.3 3.2 3 2 1 4 4 4 1 G protein-coupled glucose receptor regulating Gpa2 C-term FH2 PF02181.23 ELR20167.1 - 3.9e-80 269.8 8.0 4.7e-80 269.5 8.0 1.0 1 0 0 1 1 1 1 Formin Homology 2 Domain COMMD1_N PF17221.3 ELR20167.1 - 0.02 15.2 0.1 3.1 8.2 0.1 2.5 2 0 0 2 2 2 0 COMMD1 N-terminal domain DUF4849 PF16141.5 ELR20167.1 - 0.051 12.8 0.0 0.076 12.3 0.0 1.1 1 0 0 1 1 1 0 Putative glycoside hydrolase Family 18, chitinase_18 AP-5_subunit_s1 PF15001.6 ELR20169.1 - 9.5e-28 97.5 1.6 5.3e-22 78.8 0.7 2.0 1 1 1 2 2 2 2 AP-5 complex subunit sigma-1 His_Phos_1 PF00300.22 ELR20171.1 - 8.6e-29 100.6 4.1 1.2e-14 54.4 1.0 3.0 1 1 1 2 2 2 2 Histidine phosphatase superfamily (branch 1) TK PF00265.18 ELR20172.1 - 1.8e-66 223.3 0.1 2.3e-66 223.0 0.1 1.1 1 0 0 1 1 1 1 Thymidine kinase DUF4691 PF15762.5 ELR20172.1 - 0.022 14.9 1.5 0.041 14.0 1.5 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4691) Q_salvage PF10343.9 ELR20174.1 - 1.6e-39 136.2 0.0 2.1e-39 135.8 0.0 1.0 1 0 0 1 1 1 1 Potential Queuosine, Q, salvage protein family PRP38 PF03371.15 ELR20176.1 - 5.9e-45 153.3 0.1 7.8e-45 152.9 0.1 1.2 1 0 0 1 1 1 1 PRP38 family Apis_Csd PF11671.8 ELR20176.1 - 0.0025 17.8 0.7 0.0025 17.8 0.7 2.6 2 1 0 2 2 2 1 Complementary sex determiner protein PhyH PF05721.13 ELR20177.1 - 5e-27 95.5 0.1 2.8e-23 83.3 0.1 2.1 2 0 0 2 2 2 2 Phytanoyl-CoA dioxygenase (PhyH) ABM PF03992.16 ELR20177.1 - 0.052 13.7 0.2 0.41 10.8 0.0 2.3 3 0 0 3 3 3 0 Antibiotic biosynthesis monooxygenase SET PF00856.28 ELR20178.1 - 0.0049 17.3 0.0 0.0062 16.9 0.0 1.2 1 0 0 1 1 1 1 SET domain NAD_kinase PF01513.21 ELR20179.1 - 1e-58 198.9 0.0 2.2e-58 197.8 0.0 1.5 1 0 0 1 1 1 1 ATP-NAD kinase DAGK_cat PF00781.24 ELR20179.1 - 0.035 13.7 0.1 0.12 12.0 0.0 1.9 2 0 0 2 2 2 0 Diacylglycerol kinase catalytic domain F-box-like PF12937.7 ELR20180.1 - 3e-08 33.4 0.1 8.6e-08 32.0 0.1 1.9 1 0 0 1 1 1 1 F-box-like WD40 PF00400.32 ELR20180.1 - 5.8e-07 30.1 1.8 0.0085 16.9 0.0 3.9 3 0 0 3 3 3 2 WD domain, G-beta repeat F-box PF00646.33 ELR20180.1 - 0.00013 21.8 0.5 0.00038 20.2 0.5 1.8 1 0 0 1 1 1 1 F-box domain Coleoptericin PF06286.11 ELR20180.1 - 0.0045 17.1 1.0 0.0082 16.3 1.0 1.4 1 0 0 1 1 1 1 Coleoptericin ANAPC4_WD40 PF12894.7 ELR20180.1 - 0.01 16.1 0.0 0.43 10.9 0.0 2.8 2 1 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain NepR PF18557.1 ELR20181.1 - 0.0038 16.8 2.8 2 8.1 0.2 2.8 2 0 0 2 2 2 2 Anti-sigma factor NepR Vicilin_N PF04702.12 ELR20181.1 - 0.006 16.4 24.7 0.0083 16.0 24.7 1.1 1 0 0 1 1 1 1 Vicilin N terminal region DUF842 PF05811.13 ELR20181.1 - 0.0094 15.6 10.6 0.018 14.7 10.4 1.5 1 1 0 1 1 1 1 Eukaryotic protein of unknown function (DUF842) ApoLp-III PF07464.11 ELR20181.1 - 0.018 15.1 12.7 0.34 11.0 3.4 2.3 1 1 1 2 2 2 0 Apolipophorin-III precursor (apoLp-III) DUF2229 PF09989.9 ELR20181.1 - 0.45 10.1 18.9 1.3 8.6 10.7 2.3 1 1 1 2 2 2 0 CoA enzyme activase uncharacterised domain (DUF2229) DUF4407 PF14362.6 ELR20181.1 - 0.72 9.2 17.9 0.93 8.8 17.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) SHS2_FTSA PF02491.20 ELR20181.1 - 0.81 10.1 8.3 4.7 7.7 0.7 3.2 2 1 1 3 3 3 0 SHS2 domain inserted in FTSA YtxH PF12732.7 ELR20181.1 - 0.9 10.1 15.2 2.9 8.5 4.0 3.0 1 1 1 2 2 2 0 YtxH-like protein LPD39 PF18858.1 ELR20181.1 - 1 9.4 24.4 0.47 10.5 11.2 2.1 1 1 1 2 2 2 0 Large polyvalent protein associated domain 39 Borrelia_P83 PF05262.11 ELR20181.1 - 2.2 6.7 23.5 3 6.3 23.5 1.2 1 0 0 1 1 1 0 Borrelia P83/100 protein HAUS6_N PF14661.6 ELR20181.1 - 2.8 7.4 17.0 3.4 7.2 17.0 1.1 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus CAF-1_p150 PF11600.8 ELR20181.1 - 3.3 7.4 36.7 3 7.5 19.9 2.1 1 1 1 2 2 2 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal AAA_11 PF13086.6 ELR20181.1 - 3.5 7.4 16.6 4.3 7.0 16.6 1.1 1 0 0 1 1 1 0 AAA domain RR_TM4-6 PF06459.12 ELR20181.1 - 3.5 7.4 15.7 3.8 7.3 15.7 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 T3SSipB PF16535.5 ELR20181.1 - 4.3 7.8 15.3 5 7.6 7.3 2.0 1 1 1 2 2 2 0 Type III cell invasion protein SipB HisKA_3 PF07730.13 ELR20181.1 - 4.6 7.8 22.1 9 6.9 2.0 3.4 1 1 2 3 3 3 0 Histidine kinase Presenilin PF01080.17 ELR20181.1 - 4.7 5.9 13.3 5.3 5.7 13.3 1.0 1 0 0 1 1 1 0 Presenilin DUF883 PF05957.13 ELR20181.1 - 5.4 7.7 22.7 5.8 7.6 12.5 2.6 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF883) DUF2524 PF10732.9 ELR20181.1 - 5.7 7.3 25.1 15 6.0 11.0 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF2524) HSP70 PF00012.20 ELR20181.1 - 8.4 4.4 17.4 9.5 4.3 17.4 1.1 1 0 0 1 1 1 0 Hsp70 protein CsgE PF10627.9 ELR20181.1 - 9.2 6.5 10.3 2.4 8.4 2.3 2.2 1 1 1 2 2 2 0 Curli assembly protein CsgE MbeD_MobD PF04899.12 ELR20181.1 - 9.7 6.4 19.2 3.4 7.9 4.4 2.9 1 1 2 3 3 3 0 MbeD/MobD like Bacteriocin_IIc PF10439.9 ELR20182.1 - 5.8 7.1 9.8 15 5.8 9.8 1.8 1 0 0 1 1 1 0 Bacteriocin class II with double-glycine leader peptide ADP_ribosyl_GH PF03747.14 ELR20184.1 - 1.8e-47 162.4 0.9 2.8e-47 161.9 0.9 1.3 1 0 0 1 1 1 1 ADP-ribosylglycohydrolase Abhydrolase_1 PF00561.20 ELR20184.1 - 2.4e-20 73.2 0.5 4.2e-13 49.5 0.1 2.4 2 0 0 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 ELR20184.1 - 7.8e-15 56.1 0.0 2e-14 54.7 0.0 1.7 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 ELR20184.1 - 1.4e-10 40.9 0.2 9.2e-10 38.2 0.2 2.1 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Thioesterase PF00975.20 ELR20184.1 - 1.5e-07 31.8 0.0 2.8e-07 30.9 0.0 1.4 1 0 0 1 1 1 1 Thioesterase domain Ndr PF03096.14 ELR20184.1 - 1.9e-05 23.5 0.0 3.7e-05 22.6 0.0 1.4 1 0 0 1 1 1 1 Ndr family Esterase PF00756.20 ELR20184.1 - 0.00065 19.4 0.0 0.0012 18.5 0.0 1.4 1 0 0 1 1 1 1 Putative esterase PGAP1 PF07819.13 ELR20184.1 - 0.0097 15.7 0.1 0.03 14.0 0.1 1.8 1 1 0 1 1 1 1 PGAP1-like protein Gly-zipper_Omp PF13488.6 ELR20184.1 - 0.017 15.1 0.5 0.044 13.8 0.5 1.6 1 0 0 1 1 1 0 Glycine zipper Gly-zipper_YMGG PF13441.6 ELR20184.1 - 0.02 14.6 1.1 0.057 13.2 1.1 1.7 1 0 0 1 1 1 0 YMGG-like Gly-zipper DUF915 PF06028.11 ELR20184.1 - 0.023 14.0 0.3 0.045 13.1 0.3 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF915) Abhydrolase_5 PF12695.7 ELR20184.1 - 0.025 14.3 0.0 0.047 13.5 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase family Lipase_3 PF01764.25 ELR20184.1 - 0.031 14.1 0.0 0.081 12.8 0.0 1.6 1 0 0 1 1 1 0 Lipase (class 3) BAAT_C PF08840.11 ELR20184.1 - 0.056 13.4 0.0 0.11 12.4 0.0 1.4 1 0 0 1 1 1 0 BAAT / Acyl-CoA thioester hydrolase C terminal DUF2974 PF11187.8 ELR20184.1 - 0.065 12.8 0.0 0.13 11.8 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) Abhydrolase_3 PF07859.13 ELR20184.1 - 0.077 12.8 0.0 0.26 11.1 0.0 1.9 2 0 0 2 2 2 0 alpha/beta hydrolase fold Gly-zipper_OmpA PF13436.6 ELR20184.1 - 0.12 12.2 0.7 0.27 11.0 0.7 1.5 1 0 0 1 1 1 0 Glycine-zipper domain Methyltransf_19 PF04672.12 ELR20184.1 - 0.14 11.6 0.0 0.5 9.8 0.0 1.8 2 0 0 2 2 2 0 S-adenosyl methyltransferase Rick_17kDa_Anti PF05433.15 ELR20184.1 - 0.17 11.8 2.2 0.39 10.6 2.2 1.6 1 0 0 1 1 1 0 Glycine zipper 2TM domain PIN_4 PF13638.6 ELR20185.1 - 1.2e-06 28.9 0.0 1.2e-06 28.9 0.0 3.2 3 0 0 3 3 3 1 PIN domain LRR_6 PF13516.6 ELR20185.1 - 0.00029 20.7 0.0 0.62 10.3 0.0 3.6 3 0 0 3 3 3 1 Leucine Rich repeat YL1 PF05764.13 ELR20185.1 - 0.0072 16.5 14.2 0.0072 16.5 14.2 4.7 5 0 0 5 5 5 2 YL1 nuclear protein Peptidase_S10 PF00450.22 ELR20186.1 - 2e-115 386.6 0.3 2.3e-115 386.4 0.3 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase SUFU PF05076.13 ELR20187.1 - 5e-25 88.5 0.1 1.1e-14 54.8 0.1 2.3 2 0 0 2 2 2 2 Suppressor of fused protein (SUFU) Tyr_Deacylase PF02580.16 ELR20188.1 - 2.6e-51 173.9 0.0 2.9e-51 173.8 0.0 1.0 1 0 0 1 1 1 1 D-Tyr-tRNA(Tyr) deacylase HECT PF00632.25 ELR20189.1 - 1.3e-96 323.7 0.0 2.1e-96 323.1 0.0 1.3 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) DUF913 PF06025.12 ELR20189.1 - 3.7e-75 253.2 0.0 3.7e-75 253.2 0.0 8.9 8 2 2 10 10 10 1 Domain of Unknown Function (DUF913) DUF908 PF06012.12 ELR20189.1 - 3.9e-50 171.3 0.0 3.9e-50 171.3 0.0 8.4 7 2 1 8 8 8 1 Domain of Unknown Function (DUF908) UBM PF14377.6 ELR20189.1 - 6.5e-23 79.4 16.5 2.8e-09 36.1 0.7 4.5 3 0 0 3 3 3 3 Ubiquitin binding region UBA PF00627.31 ELR20189.1 - 1.4e-07 31.3 0.0 8.7e-07 28.7 0.0 2.4 2 0 0 2 2 2 1 UBA/TS-N domain UIM PF02809.20 ELR20189.1 - 0.023 14.6 9.4 0.061 13.3 2.2 3.2 2 0 0 2 2 2 0 Ubiquitin interaction motif RICTOR_M PF14666.6 ELR20189.1 - 0.035 13.9 0.0 0.16 11.8 0.0 2.1 2 0 0 2 2 2 0 Rapamycin-insensitive companion of mTOR, middle domain Ribosomal_60s PF00428.19 ELR20189.1 - 0.27 11.8 0.0 0.27 11.8 0.0 19.5 15 6 5 20 20 20 0 60s Acidic ribosomal protein HeLo PF14479.6 ELR20189.1 - 3.7 7.3 9.3 0.14 11.9 0.2 3.2 3 0 0 3 3 3 0 Prion-inhibition and propagation Pkinase_Tyr PF07714.17 ELR20190.1 - 7.5e-45 153.2 0.1 1.6e-44 152.2 0.1 1.6 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ELR20190.1 - 3.8e-38 131.4 0.0 7.2e-38 130.5 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain SH2 PF00017.24 ELR20190.1 - 1.9e-09 37.5 0.0 5.5e-09 36.0 0.0 1.8 1 0 0 1 1 1 1 SH2 domain Cbl_N2 PF02761.14 ELR20190.1 - 0.0079 16.9 0.0 0.021 15.5 0.0 1.7 1 0 0 1 1 1 1 CBL proto-oncogene N-terminus, EF hand-like domain APH PF01636.23 ELR20190.1 - 0.47 10.3 0.0 0.47 10.3 0.0 3.5 4 0 0 4 4 4 0 Phosphotransferase enzyme family Lip_prot_lig_C PF10437.9 ELR20191.1 - 8.3e-20 70.6 0.0 1.7e-19 69.6 0.0 1.5 1 0 0 1 1 1 1 Bacterial lipoate protein ligase C-terminus BPL_LplA_LipB PF03099.19 ELR20191.1 - 1.3e-06 28.3 0.2 1.4e-05 25.0 0.2 2.3 1 1 0 1 1 1 1 Biotin/lipoate A/B protein ligase family MRP-L27 PF09809.9 ELR20191.1 - 0.067 13.0 0.1 0.29 11.0 0.1 2.0 2 0 0 2 2 2 0 Mitochondrial ribosomal protein L27 Lipase_3 PF01764.25 ELR20192.1 - 3.4e-16 59.4 0.0 4.8e-16 58.9 0.0 1.2 1 0 0 1 1 1 1 Lipase (class 3) Pcc1 PF09341.10 ELR20193.1 - 6.7e-19 67.8 0.3 1.1e-18 67.1 0.3 1.4 1 0 0 1 1 1 1 Transcription factor Pcc1 Glyco_hyd_65N_2 PF14498.6 ELR20193.1 - 0.055 13.3 0.0 0.055 13.3 0.0 1.1 1 0 0 1 1 1 0 Glycosyl hydrolase family 65, N-terminal domain Cyto_heme_lyase PF01265.17 ELR20193.1 - 0.082 12.5 0.0 0.1 12.2 0.0 1.1 1 0 0 1 1 1 0 Cytochrome c/c1 heme lyase DUF952 PF06108.12 ELR20193.1 - 0.099 12.7 0.0 9.7 6.3 0.0 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF952) SNF2_N PF00176.23 ELR20194.1 - 1.5e-29 102.8 2.0 2.5e-27 95.5 0.0 2.7 2 1 1 3 3 3 2 SNF2 family N-terminal domain zf-C3HC4_3 PF13920.6 ELR20194.1 - 9.5e-10 38.2 6.8 9.5e-10 38.2 6.8 2.5 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 ELR20194.1 - 5.8e-09 35.7 8.3 1.8e-08 34.0 8.3 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Helicase_C PF00271.31 ELR20194.1 - 6.4e-08 32.9 0.0 1.7e-07 31.5 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Prok-RING_4 PF14447.6 ELR20194.1 - 1.3e-07 31.3 6.0 3.1e-07 30.1 6.0 1.6 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_2 PF13639.6 ELR20194.1 - 3.4e-07 30.5 8.5 9.1e-07 29.1 8.5 1.8 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 ELR20194.1 - 6.9e-07 29.0 8.7 6.9e-07 29.0 8.7 2.0 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ELR20194.1 - 2.4e-06 27.4 7.9 2.4e-06 27.4 7.9 1.8 2 0 0 2 2 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 ELR20194.1 - 4.1e-06 26.7 5.2 4.1e-06 26.7 5.2 2.0 2 0 0 2 2 2 1 RING-type zinc-finger HypA PF01155.19 ELR20194.1 - 0.0007 19.6 4.3 0.0056 16.7 0.0 2.7 2 0 0 2 2 2 1 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-rbx1 PF12678.7 ELR20194.1 - 0.00083 19.6 3.7 0.0027 18.0 3.7 1.9 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-P11 PF03854.14 ELR20194.1 - 0.0055 16.3 2.4 0.012 15.3 2.4 1.5 1 0 0 1 1 1 1 P-11 zinc finger PXT1 PF15214.6 ELR20194.1 - 0.0067 16.8 0.0 0.018 15.4 0.0 1.7 1 0 0 1 1 1 1 Peroxisomal testis-specific protein 1 SAP PF02037.27 ELR20194.1 - 0.056 13.2 0.4 13 5.6 0.0 3.6 3 0 0 3 3 3 0 SAP domain zf-RING_11 PF17123.5 ELR20194.1 - 0.42 10.4 7.2 1.2 8.9 7.2 1.8 1 0 0 1 1 1 0 RING-like zinc finger CpXC PF14353.6 ELR20194.1 - 0.49 10.5 3.8 0.86 9.7 0.0 3.2 3 0 0 3 3 2 0 CpXC protein zf-C3HC4_4 PF15227.6 ELR20194.1 - 0.6 10.3 9.1 1.8 8.8 9.1 1.9 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-RING_6 PF14835.6 ELR20194.1 - 0.94 9.4 4.0 2.3 8.2 4.0 1.6 1 0 0 1 1 1 0 zf-RING of BARD1-type protein zf-RING_4 PF14570.6 ELR20194.1 - 1.2 9.0 12.4 0.063 13.1 6.0 2.2 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain zf-RING_10 PF16685.5 ELR20194.1 - 1.4 9.1 9.8 0.32 11.2 4.0 2.4 2 0 0 2 2 2 0 zinc RING finger of MSL2 Asp-B-Hydro_N PF05279.11 ELR20195.1 - 0.065 13.3 1.2 0.098 12.7 1.2 1.1 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region Mitofilin PF09731.9 ELR20195.1 - 0.16 10.7 3.6 0.2 10.4 3.6 1.0 1 0 0 1 1 1 0 Mitochondrial inner membrane protein Macoilin PF09726.9 ELR20195.1 - 1.5 7.3 7.1 1.9 6.9 7.1 1.0 1 0 0 1 1 1 0 Macoilin family Presenilin PF01080.17 ELR20195.1 - 1.8 7.2 5.1 2.1 7.0 5.1 1.1 1 0 0 1 1 1 0 Presenilin DUF4436 PF14494.6 ELR20197.1 - 1.1e-22 80.5 0.5 1.5e-22 80.1 0.5 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4436) VDE PF07137.11 ELR20198.1 - 0.00031 20.3 13.4 0.00031 20.3 13.4 1.4 1 1 0 1 1 1 1 VDE lipocalin domain RCC1 PF00415.18 ELR20199.1 - 8.8e-36 122.3 7.5 6.4e-11 42.7 0.0 7.0 5 1 1 6 6 6 5 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 ELR20199.1 - 1e-16 60.3 13.3 1.2e-06 28.1 1.1 6.4 6 0 0 6 6 6 4 Regulator of chromosome condensation (RCC1) repeat F-box-like PF12937.7 ELR20199.1 - 1.1e-06 28.5 0.1 2.2e-06 27.4 0.1 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ELR20199.1 - 0.0006 19.6 1.3 0.0012 18.7 1.3 1.4 1 0 0 1 1 1 1 F-box domain DnaJ-X PF14308.6 ELR20200.1 - 3.2e-36 124.8 8.9 3.2e-36 124.8 8.9 1.6 1 1 0 1 1 1 1 X-domain of DnaJ-containing DnaJ PF00226.31 ELR20200.1 - 3.3e-20 72.0 0.1 9e-20 70.6 0.1 1.8 1 0 0 1 1 1 1 DnaJ domain MAS20 PF02064.15 ELR20200.1 - 3.4 7.8 10.2 0.23 11.6 3.3 2.5 3 0 0 3 3 3 0 MAS20 protein import receptor PH PF00169.29 ELR20201.1 - 7.4e-15 55.4 0.0 1.5e-14 54.3 0.0 1.6 1 0 0 1 1 1 1 PH domain Peptidase_C92 PF05708.12 ELR20201.1 - 2.3e-06 27.8 0.0 9.9e-06 25.7 0.0 1.9 1 1 0 1 1 1 1 Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family PH_11 PF15413.6 ELR20201.1 - 1.3e-05 25.5 0.2 0.0002 21.8 0.2 2.4 1 1 0 1 1 1 1 Pleckstrin homology domain MAM33 PF02330.16 ELR20201.1 - 0.047 13.6 0.6 0.092 12.7 0.6 1.4 1 0 0 1 1 1 0 Mitochondrial glycoprotein Methyltransf_2 PF00891.18 ELR20202.1 - 2.3e-36 125.0 0.2 3.3e-36 124.6 0.2 1.2 1 0 0 1 1 1 1 O-methyltransferase domain Dimerisation2 PF16864.5 ELR20202.1 - 0.00025 21.0 0.3 0.00075 19.4 0.0 1.8 2 0 0 2 2 2 1 Dimerisation domain Methyltransf_25 PF13649.6 ELR20202.1 - 0.017 15.8 0.6 0.094 13.4 0.0 2.4 3 0 0 3 3 3 0 Methyltransferase domain HTH_20 PF12840.7 ELR20202.1 - 0.047 13.7 0.0 0.97 9.5 0.0 2.8 3 0 0 3 3 3 0 Helix-turn-helix domain TrmB PF01978.19 ELR20202.1 - 0.091 12.7 0.0 0.19 11.6 0.0 1.5 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB DUF4250 PF14056.6 ELR20202.1 - 0.11 12.4 0.1 5.9 6.9 0.0 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4250) Methyltransf_12 PF08242.12 ELR20202.1 - 0.12 13.1 0.1 0.74 10.6 0.0 2.1 2 0 0 2 2 2 0 Methyltransferase domain CAP_C PF08603.11 ELR20203.1 - 1.8e-13 50.4 0.0 1.7e-12 47.3 0.0 2.0 1 1 0 1 1 1 1 Adenylate cyclase associated (CAP) C terminal TBCC PF07986.12 ELR20203.1 - 0.00039 20.1 3.0 0.13 12.0 0.7 2.8 2 1 0 2 2 2 2 Tubulin binding cofactor C Peptidase_M48 PF01435.18 ELR20205.1 - 1.5e-33 116.2 0.0 3e-33 115.3 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M48 MIF4G PF02854.19 ELR20206.1 - 7.4e-20 71.5 0.0 2.6e-19 69.7 0.0 2.0 1 1 0 1 1 1 1 MIF4G domain Nsp1_C PF05064.13 ELR20206.1 - 2.4e-10 40.2 0.0 7.2e-10 38.7 0.0 1.7 1 0 0 1 1 1 1 Nsp1-like C-terminal region YL1 PF05764.13 ELR20206.1 - 2.3 8.3 5.8 1.7 8.7 0.3 2.5 2 0 0 2 2 2 0 YL1 nuclear protein Baculo_PEP_C PF04513.12 ELR20206.1 - 2.7 8.0 4.4 1.7 8.6 0.5 2.5 3 0 0 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF563 PF04577.14 ELR20207.1 - 2e-26 93.4 0.5 3.1e-26 92.8 0.5 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF563) 4HBT_3 PF13622.6 ELR20208.1 - 2.1 8.5 16.3 0.21 11.8 3.1 2.2 2 1 0 2 2 2 0 Thioesterase-like superfamily SMC_Nse1 PF07574.13 ELR20210.1 - 7.8e-22 78.1 0.0 3.8e-16 59.6 0.0 2.2 1 1 1 2 2 2 2 Nse1 non-SMC component of SMC5-6 complex zf-RING-like PF08746.11 ELR20210.1 - 1.6e-06 28.3 4.7 3.7e-06 27.1 4.7 1.7 1 1 0 1 1 1 1 RING-like domain zf-RING_2 PF13639.6 ELR20210.1 - 0.0024 18.2 5.2 0.0043 17.3 5.2 1.5 1 0 0 1 1 1 1 Ring finger domain FYDLN_acid PF09538.10 ELR20210.1 - 0.0068 17.1 2.8 0.013 16.2 2.8 1.4 1 0 0 1 1 1 1 Protein of unknown function (FYDLN_acid) zf-HC5HC2H PF13771.6 ELR20210.1 - 0.0073 16.5 1.9 0.013 15.7 1.9 1.5 1 0 0 1 1 1 1 PHD-like zinc-binding domain zf-HC5HC2H_2 PF13832.6 ELR20210.1 - 0.0096 16.1 0.4 0.017 15.2 0.4 1.4 1 0 0 1 1 1 1 PHD-zinc-finger like domain Zn_ribbon_17 PF17120.5 ELR20210.1 - 0.074 12.7 2.9 0.16 11.6 2.9 1.6 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type FANCL_C PF11793.8 ELR20210.1 - 0.51 10.6 5.2 1.2 9.3 5.2 1.7 1 1 0 1 1 1 0 FANCL C-terminal domain HalOD2 PF18547.1 ELR20210.1 - 2.9 7.9 8.8 0.31 11.0 1.2 2.7 2 1 1 3 3 3 0 Halobacterial output domain 2 Dfp1_Him1_M PF08630.10 ELR20211.1 - 0.057 13.6 0.0 0.081 13.1 0.0 1.3 1 0 0 1 1 1 0 Dfp1/Him1, central region JHD PF17811.1 ELR20212.1 - 7.6e-16 58.5 0.3 1.6e-15 57.5 0.3 1.5 1 0 0 1 1 1 1 Jumonji helical domain JmjC PF02373.22 ELR20212.1 - 4.4e-08 33.6 0.7 2e-06 28.2 0.7 2.6 1 1 0 1 1 1 1 JmjC domain, hydroxylase Cupin_8 PF13621.6 ELR20212.1 - 6.1e-06 26.1 1.9 1.5e-05 24.9 0.2 2.3 2 1 0 2 2 2 1 Cupin-like domain YL1 PF05764.13 ELR20212.1 - 0.00014 22.1 21.8 0.0022 18.1 9.9 2.4 2 0 0 2 2 2 2 YL1 nuclear protein Actin PF00022.19 ELR20214.1 - 1.2e-82 277.7 0.0 1e-41 142.9 0.0 2.0 1 1 1 2 2 2 2 Actin Pyrid_ox_like PF16242.5 ELR20215.1 - 3.1e-39 133.9 0.2 3.9e-39 133.6 0.2 1.1 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase like Putative_PNPOx PF01243.20 ELR20215.1 - 1.2e-08 35.0 0.0 2.3e-08 34.1 0.0 1.5 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase RNA_POL_M_15KD PF02150.16 ELR20216.1 - 6.9e-06 25.8 0.4 6.9e-06 25.8 0.4 2.6 3 0 0 3 3 3 1 RNA polymerases M/15 Kd subunit TFIIS_C PF01096.18 ELR20216.1 - 0.00013 21.7 0.7 0.04 13.8 0.1 2.5 2 0 0 2 2 2 2 Transcription factor S-II (TFIIS) UBA PF00627.31 ELR20217.1 - 1.8e-17 62.9 0.1 4e-08 33.0 0.0 3.1 2 1 0 2 2 2 2 UBA/TS-N domain HOIP-UBA PF16678.5 ELR20217.1 - 0.0063 16.5 0.6 0.034 14.1 0.4 2.0 2 0 0 2 2 2 1 HOIP UBA domain pair Lysyl_oxidase PF01186.17 ELR20218.1 - 1.7e-12 47.5 0.0 2.9e-12 46.7 0.0 1.3 1 0 0 1 1 1 1 Lysyl oxidase PKD PF00801.20 ELR20218.1 - 1.5e-06 27.9 3.9 1.5e-06 27.9 3.9 3.6 3 0 0 3 3 3 1 PKD domain Fez1 PF06818.15 ELR20219.1 - 0.00017 22.1 2.8 0.00028 21.4 2.8 1.3 1 0 0 1 1 1 1 Fez1 ARGLU PF15346.6 ELR20219.1 - 0.0026 17.6 3.1 0.0039 17.1 3.1 1.2 1 0 0 1 1 1 1 Arginine and glutamate-rich 1 APG6_N PF17675.1 ELR20219.1 - 0.014 16.0 1.7 0.021 15.4 1.7 1.3 1 0 0 1 1 1 0 Apg6 coiled-coil region SWIRM-assoc_1 PF16495.5 ELR20219.1 - 0.19 11.7 6.7 0.18 11.8 5.0 1.7 1 1 0 1 1 1 0 SWIRM-associated region 1 CcdA PF07362.12 ELR20219.1 - 1.7 9.1 5.0 3.2 8.2 5.0 1.4 1 0 0 1 1 1 0 Post-segregation antitoxin CcdA LprI PF07007.12 ELR20219.1 - 4.6 7.9 7.5 13 6.5 7.5 1.7 1 1 0 1 1 1 0 Lysozyme inhibitor LprI P5CR_dimer PF14748.6 ELR20220.1 - 8.7e-42 141.6 2.9 9.8e-42 141.4 1.3 1.9 2 0 0 2 2 2 1 Pyrroline-5-carboxylate reductase dimerisation F420_oxidored PF03807.17 ELR20220.1 - 1e-19 70.9 0.1 2.5e-19 69.7 0.1 1.7 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent NAD_Gly3P_dh_N PF01210.23 ELR20220.1 - 0.0039 17.2 2.5 0.1 12.5 2.5 2.4 1 1 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus Shikimate_DH PF01488.20 ELR20220.1 - 0.0074 16.3 0.1 0.023 14.7 0.1 1.9 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase Pan_kinase PF03309.14 ELR20220.1 - 0.015 15.1 0.0 0.023 14.5 0.0 1.3 1 0 0 1 1 1 0 Type III pantothenate kinase PDH PF02153.17 ELR20220.1 - 0.015 14.3 0.1 0.022 13.8 0.1 1.2 1 0 0 1 1 1 0 Prephenate dehydrogenase NAD_binding_2 PF03446.15 ELR20220.1 - 0.026 14.7 0.0 0.069 13.3 0.0 1.7 1 1 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase ApbA PF02558.16 ELR20220.1 - 0.049 13.3 0.5 0.098 12.3 0.5 1.6 1 1 0 1 1 1 0 Ketopantoate reductase PanE/ApbA PP2C PF00481.21 ELR20221.1 - 8.5e-60 202.5 0.0 1.1e-59 202.2 0.0 1.1 1 0 0 1 1 1 1 Protein phosphatase 2C SpoIIE PF07228.12 ELR20221.1 - 2.4e-05 24.4 0.5 0.062 13.2 0.0 2.5 2 1 0 2 2 2 2 Stage II sporulation protein E (SpoIIE) PP2C_2 PF13672.6 ELR20221.1 - 0.00016 21.4 0.0 0.00063 19.4 0.0 1.9 1 1 0 1 1 1 1 Protein phosphatase 2C GAS2 PF02187.17 ELR20223.1 - 0.00069 19.7 0.4 0.00098 19.2 0.4 1.2 1 0 0 1 1 1 1 Growth-Arrest-Specific Protein 2 Domain Pes-10 PF07149.11 ELR20223.1 - 0.044 12.8 1.6 0.049 12.7 1.6 1.2 1 0 0 1 1 1 0 Pes-10 NOA36 PF06524.12 ELR20223.1 - 4.1 6.6 10.8 5.3 6.3 10.8 1.2 1 0 0 1 1 1 0 NOA36 protein Vma12 PF11712.8 ELR20224.1 - 0.037 14.1 1.1 0.13 12.4 0.7 2.2 1 1 0 1 1 1 0 Endoplasmic reticulum-based factor for assembly of V-ATPase G0-G1_switch_2 PF15103.6 ELR20224.1 - 0.077 13.4 1.8 0.11 12.9 0.1 2.2 2 1 0 2 2 2 0 G0/G1 switch protein 2 FA_desaturase PF00487.24 ELR20224.1 - 0.11 12.3 0.0 0.15 11.8 0.0 1.1 1 0 0 1 1 1 0 Fatty acid desaturase DUF3487 PF11990.8 ELR20224.1 - 0.15 12.0 1.1 0.29 11.0 1.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3487) ATPase_gene1 PF09527.10 ELR20224.1 - 3.1 8.0 10.4 9 6.5 10.4 1.7 1 1 0 1 1 1 0 Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter DUF4383 PF14325.6 ELR20225.1 - 0.034 14.4 0.0 0.034 14.4 0.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4383) Peptidase_S10 PF00450.22 ELR20226.1 - 1.7e-104 350.6 0.1 1.9e-104 350.4 0.1 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase PDR_assoc PF08370.11 ELR20226.1 - 0.065 13.0 0.5 7.7 6.3 0.2 2.5 2 0 0 2 2 2 0 Plant PDR ABC transporter associated Homeobox_KN PF05920.11 ELR20227.1 - 6.5e-16 58.0 0.1 1.5e-15 56.8 0.1 1.7 1 0 0 1 1 1 1 Homeobox KN domain PBC PF03792.13 ELR20227.1 - 1.2e-15 57.7 9.2 1.9e-15 57.1 0.5 3.3 3 0 0 3 3 3 1 PBC domain Homeodomain PF00046.29 ELR20227.1 - 3.6e-13 49.1 0.5 3.6e-13 49.1 0.5 2.2 2 0 0 2 2 2 1 Homeodomain DUF3086 PF11285.8 ELR20227.1 - 0.011 14.9 0.4 0.011 14.9 0.4 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3086) YdaS_antitoxin PF15943.5 ELR20227.1 - 0.13 12.1 0.0 0.29 11.0 0.0 1.5 1 0 0 1 1 1 0 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT DUF488 PF04343.13 ELR20228.1 - 1.9e-15 57.6 0.0 2.4e-15 57.2 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function, DUF488 DUF523 PF04463.12 ELR20228.1 - 0.13 12.3 0.0 0.24 11.5 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF523) Peptidase_S10 PF00450.22 ELR20229.1 - 1.3e-97 327.9 0.1 1.5e-97 327.6 0.1 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase Cyclin PF08613.11 ELR20230.1 - 1.6e-07 31.8 5.1 3.3e-07 30.8 5.1 1.6 1 1 0 1 1 1 1 Cyclin PSDC PF12588.8 ELR20230.1 - 0.05 13.6 0.1 0.096 12.7 0.1 1.4 1 0 0 1 1 1 0 Phophatidylserine decarboxylase Glu_synthase PF01645.17 ELR20230.1 - 0.1 11.7 0.1 0.13 11.4 0.1 1.2 1 0 0 1 1 1 0 Conserved region in glutamate synthase Ins134_P3_kin PF05770.11 ELR20231.1 - 7.6e-45 152.9 0.0 1.1e-44 152.3 0.0 1.2 1 0 0 1 1 1 1 Inositol 1,3,4-trisphosphate 5/6-kinase ATP-grasp domain Ins134_P3_kin_N PF17927.1 ELR20231.1 - 6.4e-11 42.5 0.0 1.4e-10 41.4 0.0 1.7 1 0 0 1 1 1 1 Inositol 1,3,4-trisphosphate 5/6-kinase pre-ATP-grasp domain LacY_symp PF01306.19 ELR20231.1 - 0.18 10.5 0.0 0.25 10.1 0.0 1.1 1 0 0 1 1 1 0 LacY proton/sugar symporter Asp-B-Hydro_N PF05279.11 ELR20232.1 - 0.0008 19.6 15.8 0.0012 19.0 15.8 1.2 1 0 0 1 1 1 1 Aspartyl beta-hydroxylase N-terminal region Mitofilin PF09731.9 ELR20232.1 - 0.34 9.7 17.8 0.42 9.4 17.8 1.0 1 0 0 1 1 1 0 Mitochondrial inner membrane protein Macoilin PF09726.9 ELR20232.1 - 0.91 8.0 22.2 1.2 7.6 22.2 1.0 1 0 0 1 1 1 0 Macoilin family SRA1 PF07304.11 ELR20232.1 - 9.7 6.0 7.1 24 4.7 7.1 1.8 1 1 0 1 1 1 0 Steroid receptor RNA activator (SRA1) FIST PF08495.10 ELR20233.1 - 2.1e-18 66.9 0.0 4.1e-18 66.0 0.0 1.5 1 0 0 1 1 1 1 FIST N domain FIST_C PF10442.9 ELR20233.1 - 2e-05 24.6 0.0 4.3e-05 23.5 0.0 1.5 1 0 0 1 1 1 1 FIST C domain DUF3246 PF11596.8 ELR20233.1 - 0.12 11.8 14.3 0.15 11.4 2.4 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3246) Dicty_REP PF05086.12 ELR20233.1 - 2.4 6.0 20.0 0.024 12.6 10.1 1.9 2 0 0 2 2 2 0 Dictyostelium (Slime Mold) REP protein Podoplanin PF05808.11 ELR20233.1 - 7.1 6.7 7.7 33 4.6 0.0 2.4 2 0 0 2 2 2 0 Podoplanin Rap_GAP PF02145.15 ELR20234.1 - 7.1e-63 211.5 0.0 1.1e-62 210.9 0.0 1.3 1 0 0 1 1 1 1 Rap/ran-GAP PALP PF00291.25 ELR20235.1 - 8.2e-29 100.9 0.0 1.3e-27 97.0 0.0 2.0 1 1 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme DcpS_C PF11969.8 ELR20235.1 - 6.3e-20 71.8 0.0 1.2e-19 70.9 0.0 1.4 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding HIT PF01230.23 ELR20235.1 - 1.1e-07 32.4 0.3 2.8e-07 31.2 0.3 1.6 1 0 0 1 1 1 1 HIT domain zf-C2HE PF16278.5 ELR20235.1 - 2e-06 28.1 0.0 4.6e-06 27.0 0.0 1.6 1 0 0 1 1 1 1 C2HE / C2H2 / C2HC zinc-binding finger RhoGAP PF00620.27 ELR20236.1 - 1.1e-33 116.2 0.2 1.1e-33 116.2 0.2 1.6 2 0 0 2 2 2 1 RhoGAP domain SH3_2 PF07653.17 ELR20236.1 - 0.0022 17.6 0.0 0.0042 16.7 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain Ank_2 PF12796.7 ELR20237.1 - 3.9e-24 85.0 1.1 1.5e-11 44.7 0.2 4.2 2 2 2 4 4 4 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 ELR20237.1 - 9.3e-24 83.2 3.2 1.8e-07 31.3 0.6 4.3 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank_4 PF13637.6 ELR20237.1 - 2.2e-23 82.3 0.2 4.6e-10 39.8 0.0 4.0 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 ELR20237.1 - 6.8e-23 78.3 1.4 7.6e-05 22.8 0.0 5.9 6 1 0 6 6 6 4 Ankyrin repeat Ank PF00023.30 ELR20237.1 - 1e-14 54.2 1.4 0.002 18.5 0.0 5.8 4 1 0 4 4 4 4 Ankyrin repeat LRR_8 PF13855.6 ELR20237.1 - 1.1e-10 41.1 3.8 1.4e-09 37.6 0.4 2.2 1 1 1 2 2 2 2 Leucine rich repeat LRR_4 PF12799.7 ELR20237.1 - 1.5e-07 31.6 5.0 6.9e-06 26.3 0.6 2.4 1 1 2 3 3 3 3 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 ELR20237.1 - 0.014 15.8 4.7 9.3 7.2 0.0 4.2 4 0 0 4 4 4 0 Leucine Rich Repeat DUF4265 PF14085.6 ELR20237.1 - 0.11 12.5 0.0 0.48 10.4 0.0 2.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4265) SIR2 PF02146.17 ELR20238.1 - 1.1e-14 54.8 0.0 1.7e-14 54.1 0.0 1.3 1 0 0 1 1 1 1 Sir2 family TPP_enzyme_M PF00205.22 ELR20238.1 - 0.004 16.9 0.0 1.5 8.6 0.0 2.3 2 0 0 2 2 2 2 Thiamine pyrophosphate enzyme, central domain Prenyltrans PF00432.21 ELR20238.1 - 0.068 12.9 0.0 0.16 11.7 0.0 1.6 1 0 0 1 1 1 0 Prenyltransferase and squalene oxidase repeat IF4E PF01652.18 ELR20240.1 - 6.3e-39 133.3 0.3 8.8e-39 132.8 0.3 1.2 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E RasGAP PF00616.19 ELR20241.1 - 5.8e-23 81.7 0.6 2.9e-17 63.1 0.1 3.2 2 1 1 3 3 3 2 GTPase-activator protein for Ras-like GTPase DEP PF00610.21 ELR20241.1 - 5e-10 39.3 0.7 1.6e-09 37.7 0.1 2.2 3 0 0 3 3 3 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) PUL PF08324.11 ELR20241.1 - 0.055 12.7 0.0 0.13 11.5 0.0 1.6 1 0 0 1 1 1 0 PUL domain Med19 PF10278.9 ELR20241.1 - 8 6.4 11.2 19 5.1 11.2 1.6 1 0 0 1 1 1 0 Mediator of RNA pol II transcription subunit 19 Ribosomal_L34 PF00468.17 ELR20242.1 - 9e-17 60.8 7.5 1.2e-16 60.4 7.5 1.2 1 0 0 1 1 1 1 Ribosomal protein L34 BTB_2 PF02214.22 ELR20243.1 - 2.2e-19 69.6 0.0 3.7e-19 68.9 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain WD40 PF00400.32 ELR20243.1 - 2.1e-18 66.3 19.5 0.0002 22.1 0.0 7.1 7 0 0 7 7 7 6 WD domain, G-beta repeat WD40_like PF17005.5 ELR20243.1 - 0.0046 16.3 0.0 0.012 14.9 0.0 1.7 2 0 0 2 2 2 1 WD40-like domain BTB PF00651.31 ELR20243.1 - 0.065 13.5 0.0 0.12 12.6 0.0 1.3 1 0 0 1 1 1 0 BTB/POZ domain Pkinase PF00069.25 ELR20244.1 - 5.9e-63 212.7 0.4 1.5e-62 211.4 0.0 1.9 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR20244.1 - 7.8e-35 120.4 0.0 2.9e-34 118.5 0.0 1.9 1 1 0 1 1 1 1 Protein tyrosine kinase GRAM PF02893.20 ELR20244.1 - 8.9e-20 70.7 0.3 1.6e-19 69.8 0.3 1.4 1 0 0 1 1 1 1 GRAM domain Kinase-like PF14531.6 ELR20244.1 - 0.002 17.5 0.1 0.0064 15.8 0.0 1.8 2 0 0 2 2 2 1 Kinase-like Drc1-Sld2 PF11719.8 ELR20244.1 - 0.033 13.7 8.8 0.059 12.9 8.8 1.4 1 0 0 1 1 1 0 DNA replication and checkpoint protein bPH_3 PF14470.6 ELR20244.1 - 0.056 13.8 0.1 0.11 12.9 0.1 1.5 1 0 0 1 1 1 0 Bacterial PH domain DUF4413 PF14372.6 ELR20244.1 - 1.9 8.9 4.1 6.2 7.2 0.4 2.5 1 1 0 2 2 2 0 Domain of unknown function (DUF4413) Cwf_Cwc_15 PF04889.12 ELR20244.1 - 2.5 7.8 22.1 5 6.8 22.1 1.5 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein DivIC PF04977.15 ELR20244.1 - 2.6 7.9 10.3 0.81 9.5 3.0 2.6 2 0 0 2 2 2 0 Septum formation initiator Pkinase_Tyr PF07714.17 ELR20245.1 - 7.8e-124 412.1 0.0 3.8e-63 213.2 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 ELR20245.1 - 3.3e-101 338.1 0.0 6.6e-56 189.6 0.0 2.3 2 0 0 2 2 2 2 Protein kinase domain PBP_like_2 PF12849.7 ELR20245.1 - 1.1e-27 97.5 7.4 3e-15 56.7 0.7 2.5 2 0 0 2 2 2 2 PBP superfamily domain Guanylate_cyc PF00211.20 ELR20245.1 - 2.7e-09 36.9 0.0 5.4e-09 35.9 0.0 1.4 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain Haspin_kinase PF12330.8 ELR20245.1 - 3.1e-06 26.4 0.0 0.005 15.8 0.0 2.2 2 0 0 2 2 2 2 Haspin like kinase domain APH PF01636.23 ELR20245.1 - 3.1e-06 27.3 0.7 0.0024 17.9 0.0 3.2 3 1 1 4 4 4 1 Phosphotransferase enzyme family Kdo PF06293.14 ELR20245.1 - 0.00031 20.2 0.0 0.15 11.4 0.0 2.3 2 0 0 2 2 2 2 Lipopolysaccharide kinase (Kdo/WaaP) family TMEM154 PF15102.6 ELR20245.1 - 0.00087 19.2 0.0 0.0018 18.2 0.0 1.4 1 0 0 1 1 1 1 TMEM154 protein family FTA2 PF13095.6 ELR20245.1 - 0.0016 18.1 0.0 0.074 12.7 0.0 3.0 3 1 1 4 4 4 1 Kinetochore Sim4 complex subunit FTA2 Kinase-like PF14531.6 ELR20245.1 - 0.0025 17.2 0.0 0.18 11.1 0.0 2.2 2 0 0 2 2 2 1 Kinase-like EGF_2 PF07974.13 ELR20245.1 - 0.012 15.9 12.7 0.027 14.8 12.7 1.6 1 0 0 1 1 1 0 EGF-like domain Insulin_TMD PF17870.1 ELR20245.1 - 0.06 13.4 0.7 0.18 11.9 0.7 1.8 1 0 0 1 1 1 0 Insulin receptor trans-membrane segment Mid2 PF04478.12 ELR20245.1 - 0.1 12.4 0.4 0.22 11.3 0.4 1.5 1 0 0 1 1 1 0 Mid2 like cell wall stress sensor DUF3377 PF11857.8 ELR20245.1 - 0.14 12.1 1.0 0.3 11.0 1.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3377) 7TM_GPCR_Srw PF10324.9 ELR20245.1 - 0.17 11.1 0.0 0.3 10.3 0.0 1.3 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srw CYYR1 PF10873.8 ELR20245.1 - 1.2 9.5 4.9 3.7 8.0 4.9 1.8 1 0 0 1 1 1 0 Cysteine and tyrosine-rich protein 1 Trypan_PARP PF05887.11 ELR20246.1 - 0.1 12.6 112.1 1.7 8.6 15.6 7.6 1 1 3 4 4 4 0 Procyclic acidic repetitive protein (PARP) fn3 PF00041.21 ELR20247.1 - 1.1e-108 355.8 48.7 7.6e-13 48.6 1.4 12.5 10 3 0 10 10 10 10 Fibronectin type III domain Pur_ac_phosph_N PF16656.5 ELR20247.1 - 1.4e-05 25.5 50.5 0.051 14.1 0.5 12.2 9 6 1 10 10 10 4 Purple acid Phosphatase, N-terminal domain Big_10 PF17964.1 ELR20247.1 - 0.0021 18.1 14.4 10 6.0 0.1 7.5 8 0 0 8 8 8 2 Bacterial Ig domain GTP_EFTU PF00009.27 ELR20248.1 - 6.9e-14 51.8 0.0 1.7e-13 50.5 0.0 1.6 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain F-box-like PF12937.7 ELR20248.1 - 0.0014 18.4 0.9 0.0031 17.4 0.9 1.6 1 0 0 1 1 1 1 F-box-like AAA_22 PF13401.6 ELR20248.1 - 0.011 16.0 0.1 0.026 14.8 0.0 1.7 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.6 ELR20248.1 - 0.011 16.1 0.0 0.025 14.9 0.0 1.6 1 1 0 1 1 1 0 AAA ATPase domain RsgA_GTPase PF03193.16 ELR20248.1 - 0.026 14.5 0.3 4.2 7.3 0.1 3.1 2 1 0 2 2 2 0 RsgA GTPase AAA_33 PF13671.6 ELR20248.1 - 0.039 14.1 0.1 0.083 13.1 0.1 1.6 1 1 0 1 1 1 0 AAA domain AAA PF00004.29 ELR20248.1 - 0.069 13.6 0.1 1.2 9.6 0.0 2.2 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_29 PF13555.6 ELR20248.1 - 0.13 12.1 0.0 0.31 10.8 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain GTP_EFTU_D3 PF03143.17 ELR20249.1 - 2.1e-11 44.1 0.0 6.7e-06 26.4 0.0 2.4 1 1 1 2 2 2 2 Elongation factor Tu C-terminal domain HPP PF04982.13 ELR20250.1 - 8.1e-30 103.5 13.4 8.1e-30 103.5 13.4 1.8 2 0 0 2 2 2 1 HPP family Pkinase PF00069.25 ELR20251.1 - 1.9e-69 233.9 0.0 2.8e-69 233.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR20251.1 - 7.7e-47 159.7 0.0 1.1e-46 159.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase PH PF00169.29 ELR20251.1 - 9.2e-20 71.1 0.1 2.2e-19 69.9 0.1 1.7 1 0 0 1 1 1 1 PH domain PBD PF00786.28 ELR20251.1 - 6.5e-14 52.0 0.0 1.6e-13 50.8 0.0 1.7 1 0 0 1 1 1 1 P21-Rho-binding domain Pkinase_fungal PF17667.1 ELR20251.1 - 6.7e-07 28.4 0.0 1.1e-06 27.7 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase PH_11 PF15413.6 ELR20251.1 - 5.9e-05 23.4 0.2 0.00022 21.6 0.2 2.1 1 1 0 1 1 1 1 Pleckstrin homology domain PH_9 PF15410.6 ELR20251.1 - 0.00017 21.9 0.0 0.0005 20.4 0.0 1.8 1 1 0 1 1 1 1 Pleckstrin homology domain Kinase-like PF14531.6 ELR20251.1 - 0.0011 18.4 0.0 0.028 13.8 0.0 2.2 2 0 0 2 2 2 1 Kinase-like Methyltransf_23 PF13489.6 ELR20252.1 - 2e-23 83.1 0.0 2.6e-23 82.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ELR20252.1 - 3.6e-20 72.4 0.0 5.6e-20 71.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ELR20252.1 - 1.1e-15 58.1 0.0 1.6e-15 57.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ELR20252.1 - 3.2e-14 53.0 0.0 4.2e-14 52.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ELR20252.1 - 1e-13 51.9 0.0 1.5e-13 51.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 ELR20252.1 - 2.3e-08 33.7 0.0 3.3e-08 33.1 0.0 1.1 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Ubie_methyltran PF01209.18 ELR20252.1 - 0.00014 21.2 0.0 0.00021 20.7 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_9 PF08003.11 ELR20252.1 - 0.0015 17.5 0.0 0.0021 17.0 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) PrmA PF06325.13 ELR20252.1 - 0.0021 17.5 0.0 0.003 17.0 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_32 PF13679.6 ELR20252.1 - 0.0034 17.4 0.0 0.0054 16.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain DREV PF05219.12 ELR20252.1 - 0.012 14.8 0.0 0.015 14.4 0.0 1.2 1 0 0 1 1 1 0 DREV methyltransferase NodS PF05401.11 ELR20252.1 - 0.012 15.2 0.0 0.019 14.6 0.0 1.2 1 0 0 1 1 1 0 Nodulation protein S (NodS) MTS PF05175.14 ELR20252.1 - 0.023 14.2 0.0 0.039 13.5 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain MetW PF07021.12 ELR20252.1 - 0.16 11.5 0.0 0.25 10.9 0.0 1.3 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW CBM_25 PF03423.13 ELR20253.1 - 0.088 13.1 0.4 0.31 11.3 0.1 2.0 2 0 0 2 2 2 0 Carbohydrate binding domain (family 25) Pkinase_Tyr PF07714.17 ELR20256.1 - 7.5e-42 143.4 0.0 1.1e-41 142.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ELR20256.1 - 2.7e-36 125.3 0.0 4.4e-36 124.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_fungal PF17667.1 ELR20256.1 - 0.0079 15.0 0.2 0.017 13.9 0.0 1.6 2 0 0 2 2 2 1 Fungal protein kinase APH PF01636.23 ELR20256.1 - 0.013 15.4 1.9 0.082 12.8 0.3 2.7 2 1 1 3 3 3 0 Phosphotransferase enzyme family Kdo PF06293.14 ELR20256.1 - 0.019 14.3 0.0 0.041 13.2 0.0 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family STAT_alpha PF01017.20 ELR20256.1 - 0.023 14.6 1.7 0.036 13.9 1.7 1.3 1 0 0 1 1 1 0 STAT protein, all-alpha domain Mis14 PF08641.12 ELR20256.1 - 0.081 13.2 0.0 0.3 11.4 0.0 1.8 2 0 0 2 2 2 0 Kinetochore protein Mis14 like Syntaxin-6_N PF09177.11 ELR20256.1 - 0.13 12.8 1.6 0.28 11.8 1.6 1.5 1 0 0 1 1 1 0 Syntaxin 6, N-terminal Exonuc_VII_L PF02601.15 ELR20256.1 - 0.29 10.6 2.2 0.48 9.9 2.2 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit TMF_TATA_bd PF12325.8 ELR20256.1 - 1 9.6 7.4 0.22 11.7 4.2 1.5 2 0 0 2 2 2 0 TATA element modulatory factor 1 TATA binding CLZ PF16526.5 ELR20256.1 - 1.1 9.7 3.9 0.47 10.9 0.1 2.2 2 0 0 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Ribosomal_L15e PF00827.17 ELR20258.1 - 0.16 11.7 0.4 0.38 10.4 0.0 1.7 2 0 0 2 2 2 0 Ribosomal L15 FAD_binding_1 PF00667.20 ELR20259.1 - 1.6e-56 191.4 0.0 2.5e-56 190.7 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain Flavodoxin_1 PF00258.25 ELR20259.1 - 1.4e-26 93.4 1.0 3.4e-26 92.2 0.8 1.8 2 0 0 2 2 2 1 Flavodoxin NAD_binding_1 PF00175.21 ELR20259.1 - 1.7e-17 64.1 0.1 2.6e-16 60.2 0.1 2.5 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain Prismane PF03063.20 ELR20260.1 - 2.4e-160 534.6 0.0 2.9e-160 534.4 0.0 1.1 1 0 0 1 1 1 1 Prismane/CO dehydrogenase family 7tm_2 PF00002.24 ELR20263.1 - 8e-17 61.3 2.4 9.5e-17 61.1 2.4 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) Dicty_CAR PF05462.11 ELR20263.1 - 6.2e-14 51.8 5.8 7.4e-14 51.6 5.8 1.1 1 0 0 1 1 1 1 Slime mold cyclic AMP receptor Frizzled PF01534.17 ELR20263.1 - 2.6e-05 23.4 2.9 3.2e-05 23.1 2.9 1.1 1 0 0 1 1 1 1 Frizzled/Smoothened family membrane region Ocular_alb PF02101.15 ELR20263.1 - 0.0002 20.4 4.7 0.00028 19.9 4.7 1.2 1 0 0 1 1 1 1 Ocular albinism type 1 protein DUF1772 PF08592.11 ELR20263.1 - 0.012 16.0 0.0 0.019 15.3 0.0 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF1772) DAO PF01266.24 ELR20264.1 - 1.1e-09 38.4 0.4 1.2e-09 38.2 0.4 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 ELR20264.1 - 3.3e-07 30.5 2.5 2.1e-06 27.9 2.0 2.1 1 1 1 2 2 2 1 NAD(P)-binding Rossmann-like domain FAD_binding_3 PF01494.19 ELR20264.1 - 6.5e-07 28.9 0.2 7.1e-07 28.8 0.2 1.2 1 0 0 1 1 1 1 FAD binding domain FAD_binding_2 PF00890.24 ELR20264.1 - 1.2e-05 24.6 0.5 1.5e-05 24.3 0.5 1.2 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 ELR20264.1 - 6.6e-05 22.3 0.2 7.6e-05 22.1 0.2 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 ELR20264.1 - 9.1e-05 21.8 0.6 0.00012 21.4 0.6 1.1 1 0 0 1 1 1 1 Thi4 family Pyr_redox_3 PF13738.6 ELR20264.1 - 0.00092 18.6 0.1 0.0011 18.3 0.1 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 ELR20264.1 - 0.0011 18.4 0.5 0.0012 18.3 0.5 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase HI0933_like PF03486.14 ELR20264.1 - 0.0017 17.1 1.4 0.0022 16.8 1.4 1.1 1 0 0 1 1 1 1 HI0933-like protein IlvN PF07991.12 ELR20264.1 - 0.0085 15.7 0.1 0.011 15.3 0.1 1.2 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain UDPG_MGDP_dh_N PF03721.14 ELR20264.1 - 0.0096 15.5 0.2 0.01 15.4 0.2 1.2 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Lycopene_cycl PF05834.12 ELR20264.1 - 0.01 14.9 0.7 0.013 14.6 0.7 1.1 1 0 0 1 1 1 0 Lycopene cyclase protein Pyr_redox PF00070.27 ELR20264.1 - 0.012 16.2 2.3 0.022 15.3 2.3 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase 3HCDH_N PF02737.18 ELR20264.1 - 0.012 15.5 0.3 0.015 15.2 0.3 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_Gly3P_dh_N PF01210.23 ELR20264.1 - 0.019 14.9 0.1 0.023 14.7 0.1 1.3 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus TrkA_N PF02254.18 ELR20264.1 - 0.023 14.9 0.3 0.04 14.2 0.2 1.4 1 1 0 1 1 1 0 TrkA-N domain GIDA PF01134.22 ELR20264.1 - 0.026 13.6 1.5 0.042 12.9 1.3 1.4 1 1 0 1 1 1 0 Glucose inhibited division protein A Trp_halogenase PF04820.14 ELR20264.1 - 0.051 12.4 0.1 0.058 12.2 0.1 1.1 1 0 0 1 1 1 0 Tryptophan halogenase NAD_binding_7 PF13241.6 ELR20264.1 - 0.069 13.6 0.1 0.08 13.4 0.1 1.2 1 0 0 1 1 1 0 Putative NAD(P)-binding Shikimate_DH PF01488.20 ELR20264.1 - 0.14 12.2 0.2 0.21 11.6 0.2 1.2 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase CBS PF00571.28 ELR20266.1 - 1.8e-37 127.6 4.8 1.6e-10 41.3 0.1 4.2 4 0 0 4 4 4 4 CBS domain Acetyltransf_10 PF13673.7 ELR20266.1 - 0.0011 18.9 0.0 12 5.9 0.0 3.3 3 0 0 3 3 3 2 Acetyltransferase (GNAT) domain PRC PF05239.16 ELR20266.1 - 0.072 13.2 0.2 12 6.1 0.1 2.9 3 0 0 3 3 3 0 PRC-barrel domain IF3_N PF05198.16 ELR20266.1 - 0.29 11.4 2.4 61 4.0 0.0 3.7 4 0 0 4 4 4 0 Translation initiation factor IF-3, N-terminal domain Exo_endo_phos PF03372.23 ELR20267.1 - 2.3e-09 37.1 0.0 3.3e-09 36.6 0.0 1.4 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Helicase_C PF00271.31 ELR20268.1 - 9.2e-14 51.7 0.0 4.2e-13 49.6 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain RecQ_Zn_bind PF16124.5 ELR20268.1 - 1.5e-12 48.0 1.4 1.5e-12 48.0 1.4 2.4 2 0 0 2 2 2 1 RecQ zinc-binding DEAD PF00270.29 ELR20268.1 - 1.8e-11 44.1 0.0 1.1e-10 41.5 0.0 2.2 2 1 0 2 2 2 1 DEAD/DEAH box helicase DUF5568 PF17724.1 ELR20268.1 - 0.33 10.8 7.1 0.67 9.7 7.1 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF5568) RRM_1 PF00076.22 ELR20269.1 - 0.11 12.3 0.0 0.19 11.6 0.0 1.4 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Axin_b-cat_bind PF08833.10 ELR20270.1 - 4.3 7.5 14.9 0.19 11.8 3.7 2.8 3 0 0 3 3 3 0 Axin beta-catenin binding domain RasGEF_N PF00618.20 ELR20271.1 - 6.8e-22 77.7 0.5 7.9e-22 77.5 0.5 1.0 1 0 0 1 1 1 1 RasGEF N-terminal motif HALZ PF02183.18 ELR20272.1 - 0.034 14.4 0.4 0.073 13.3 0.4 1.5 1 0 0 1 1 1 0 Homeobox associated leucine zipper Peptidase_S9 PF00326.21 ELR20273.1 - 8.8e-07 28.6 1.2 0.0085 15.6 0.2 2.4 1 1 1 2 2 2 2 Prolyl oligopeptidase family Esterase_phd PF10503.9 ELR20273.1 - 1.1e-06 28.3 0.1 1.6e-06 27.8 0.1 1.2 1 0 0 1 1 1 1 Esterase PHB depolymerase Abhydrolase_2 PF02230.16 ELR20273.1 - 1.2e-05 25.3 0.0 2.7e-05 24.1 0.0 1.7 1 1 0 1 1 1 1 Phospholipase/Carboxylesterase Hydrolase_4 PF12146.8 ELR20273.1 - 0.0002 20.7 0.8 0.027 13.8 0.0 2.7 1 1 1 2 2 2 2 Serine aminopeptidase, S33 AXE1 PF05448.12 ELR20273.1 - 0.00031 19.5 0.0 0.00073 18.3 0.0 1.5 2 0 0 2 2 2 1 Acetyl xylan esterase (AXE1) Abhydrolase_3 PF07859.13 ELR20273.1 - 0.0061 16.4 0.1 0.12 12.2 0.0 2.1 1 1 0 2 2 2 1 alpha/beta hydrolase fold VWA_3 PF13768.6 ELR20276.1 - 1.1e-31 109.9 0.0 1.7e-31 109.3 0.0 1.2 1 0 0 1 1 1 1 von Willebrand factor type A domain Pkinase_Tyr PF07714.17 ELR20276.1 - 4.2e-16 59.0 0.0 6.2e-16 58.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase VWA PF00092.28 ELR20276.1 - 9.1e-13 48.8 0.0 1.3e-12 48.3 0.0 1.2 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.6 ELR20276.1 - 8.6e-12 45.7 0.0 2e-11 44.5 0.0 1.6 2 0 0 2 2 2 1 von Willebrand factor type A domain Pkinase PF00069.25 ELR20276.1 - 5.5e-09 35.8 0.0 8.2e-09 35.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain VWA_CoxE PF05762.14 ELR20276.1 - 1.1e-05 24.9 0.0 1.8e-05 24.3 0.0 1.2 1 0 0 1 1 1 1 VWA domain containing CoxE-like protein Mss4 PF04421.13 ELR20280.1 - 1.4e-17 63.6 0.0 1.6e-17 63.4 0.0 1.1 1 0 0 1 1 1 1 Mss4 protein zinc_ribbon_12 PF11331.8 ELR20280.1 - 0.046 13.5 0.9 0.52 10.2 0.3 2.2 2 0 0 2 2 2 0 Probable zinc-ribbon domain Ank_2 PF12796.7 ELR20281.1 - 1.5e-41 140.8 10.1 4.9e-15 55.9 0.2 5.3 3 2 3 6 6 6 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ELR20281.1 - 2.7e-41 139.4 6.6 6.9e-12 45.6 0.2 7.6 1 1 7 8 8 8 8 Ankyrin repeats (many copies) Ank_5 PF13857.6 ELR20281.1 - 3e-29 100.7 9.3 3.4e-07 30.4 0.2 7.5 2 2 5 7 7 7 6 Ankyrin repeats (many copies) Ank PF00023.30 ELR20281.1 - 3.8e-29 99.8 12.4 1.4e-05 25.3 0.2 8.4 8 0 0 8 8 8 6 Ankyrin repeat Ank_3 PF13606.6 ELR20281.1 - 5.3e-24 81.7 7.9 0.00012 22.2 0.1 8.5 8 0 0 8 8 8 4 Ankyrin repeat FH2 PF02181.23 ELR20281.1 - 7.4e-19 68.1 0.0 1.7e-18 66.9 0.0 1.6 1 0 0 1 1 1 1 Formin Homology 2 Domain Drf_FH3 PF06367.16 ELR20281.1 - 1.7e-05 24.6 0.4 0.00051 19.7 0.0 2.9 3 0 0 3 3 3 1 Diaphanous FH3 Domain BAR_2 PF10455.9 ELR20281.1 - 2.1 7.4 10.5 0.025 13.7 1.6 2.0 2 0 0 2 2 2 0 Bin/amphiphysin/Rvs domain for vesicular trafficking Borrelia_P83 PF05262.11 ELR20281.1 - 3.2 6.1 21.3 1.7 7.1 5.7 2.2 2 0 0 2 2 2 0 Borrelia P83/100 protein MDM1 PF15501.6 ELR20281.1 - 3.4 6.7 19.3 0.03 13.5 6.1 2.1 2 0 0 2 2 2 0 Nuclear protein MDM1 PHD PF00628.29 ELR20283.1 - 1.7e-16 59.9 20.4 1.5e-08 34.4 10.2 2.4 2 0 0 2 2 2 2 PHD-finger Prok-RING_1 PF14446.6 ELR20283.1 - 0.0067 16.3 17.4 0.022 14.7 3.3 2.5 2 0 0 2 2 2 2 Prokaryotic RING finger family 1 zf-PHD-like PF15446.6 ELR20283.1 - 0.015 14.9 6.6 1 9.0 1.7 2.6 2 0 0 2 2 2 0 PHD/FYVE-zinc-finger like domain zf-HC5HC2H_2 PF13832.6 ELR20283.1 - 0.028 14.6 4.6 4.4 7.5 0.1 2.3 2 0 0 2 2 2 0 PHD-zinc-finger like domain C1_1 PF00130.22 ELR20283.1 - 0.22 11.5 13.4 1.2 9.1 1.5 2.6 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Zf_RING PF16744.5 ELR20283.1 - 0.77 9.9 7.9 0.61 10.2 0.4 2.5 2 0 0 2 2 2 0 KIAA1045 RING finger DnaJ PF00226.31 ELR20284.1 - 4e-23 81.3 0.8 8.8e-23 80.2 0.8 1.6 1 0 0 1 1 1 1 DnaJ domain Thioredoxin PF00085.20 ELR20284.1 - 3.5e-22 78.3 0.0 4.2e-21 74.9 0.0 2.6 3 0 0 3 3 3 1 Thioredoxin Thioredoxin_2 PF13098.6 ELR20284.1 - 2e-05 25.0 0.0 0.00015 22.2 0.0 2.5 2 1 0 2 2 2 1 Thioredoxin-like domain TraF PF13728.6 ELR20284.1 - 0.00019 21.3 0.7 0.00053 19.9 0.0 2.0 2 0 0 2 2 2 1 F plasmid transfer operon protein OST3_OST6 PF04756.13 ELR20284.1 - 0.0028 17.0 0.0 0.0055 16.1 0.0 1.5 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family Thioredoxin_3 PF13192.6 ELR20284.1 - 0.2 11.7 0.0 1.1 9.3 0.0 2.1 2 0 0 2 2 2 0 Thioredoxin domain Spt20 PF12090.8 ELR20284.1 - 0.37 10.4 6.6 0.7 9.5 6.6 1.4 1 0 0 1 1 1 0 Spt20 family Androgen_recep PF02166.16 ELR20284.1 - 2.3 7.0 10.9 4.4 6.0 10.9 1.4 1 0 0 1 1 1 0 Androgen receptor Aminotran_1_2 PF00155.21 ELR20285.1 - 1.3e-30 106.8 0.0 2.1e-30 106.2 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.21 ELR20285.1 - 0.015 14.6 0.0 0.024 13.9 0.0 1.3 1 0 0 1 1 1 0 Beta-eliminating lyase tRNA_synthFbeta PF17759.1 ELR20287.1 - 9.7e-49 165.7 0.0 1.4e-48 165.2 0.0 1.3 1 0 0 1 1 1 1 Phenylalanyl tRNA synthetase beta chain CLM domain PhetRS_B1 PF18262.1 ELR20287.1 - 8.9e-27 93.1 0.2 9.7e-26 89.8 0.2 2.4 2 1 0 2 2 2 1 Phe-tRNA synthetase beta subunit B1 domain B3_4 PF03483.17 ELR20287.1 - 1.8e-24 86.4 0.0 3.6e-24 85.4 0.0 1.5 1 0 0 1 1 1 1 B3/4 domain B5 PF03484.15 ELR20287.1 - 1.4e-21 76.6 0.1 5.6e-19 68.2 0.0 2.6 2 0 0 2 2 2 2 tRNA synthetase B5 domain HTH_33 PF13592.6 ELR20287.1 - 0.0015 18.1 0.0 0.0053 16.4 0.0 1.9 2 0 0 2 2 2 1 Winged helix-turn helix PsbL PF02419.17 ELR20287.1 - 0.16 12.0 0.0 0.36 10.9 0.0 1.6 1 0 0 1 1 1 0 PsbL protein Glyco_hydro_77 PF02446.17 ELR20287.1 - 0.26 10.1 0.0 0.37 9.6 0.0 1.1 1 0 0 1 1 1 0 4-alpha-glucanotransferase DAGAT PF03982.13 ELR20288.1 - 1.4e-52 178.5 0.0 1.9e-52 178.0 0.0 1.1 1 0 0 1 1 1 1 Diacylglycerol acyltransferase PH PF00169.29 ELR20289.1 - 0.056 14.0 0.0 0.24 11.9 0.0 2.1 2 0 0 2 2 2 0 PH domain F-box-like PF12937.7 ELR20290.1 - 2.8e-08 33.5 1.9 6.8e-08 32.3 1.9 1.7 1 0 0 1 1 1 1 F-box-like SH2 PF00017.24 ELR20290.1 - 9.1e-05 22.5 0.0 0.0002 21.4 0.0 1.5 1 0 0 1 1 1 1 SH2 domain F-box PF00646.33 ELR20290.1 - 0.0067 16.3 0.2 0.014 15.2 0.2 1.6 1 0 0 1 1 1 1 F-box domain PQQ_3 PF13570.6 ELR20291.1 - 0.036 14.6 1.7 10 6.8 0.1 4.1 4 0 0 4 4 4 0 PQQ-like domain WD40 PF00400.32 ELR20291.1 - 0.25 12.3 3.3 2.3 9.2 0.9 3.6 4 0 0 4 4 4 0 WD domain, G-beta repeat AI-2E_transport PF01594.16 ELR20292.1 - 2.2e-38 132.2 33.9 5.4e-38 131.0 33.9 1.5 1 1 0 1 1 1 1 AI-2E family transporter Rax2 PF12768.7 ELR20292.1 - 2.2 7.7 5.0 0.6 9.5 0.5 2.0 2 0 0 2 2 2 0 Cortical protein marker for cell polarity DUF4006 PF13179.6 ELR20292.1 - 2.4 8.1 4.5 9.2 6.3 1.8 2.6 2 0 0 2 2 2 0 Family of unknown function (DUF4006) Rnk_N PF14760.6 ELR20293.1 - 0.2 12.2 0.8 0.52 10.8 0.8 1.7 1 0 0 1 1 1 0 Rnk N-terminus Gal_Lectin PF02140.18 ELR20294.1 - 3.2e-07 30.7 0.3 6.9e-07 29.6 0.3 1.5 1 0 0 1 1 1 1 Galactose binding lectin domain FG-GAP PF01839.23 ELR20294.1 - 0.0086 16.2 1.1 0.043 13.9 0.2 2.4 2 0 0 2 2 2 1 FG-GAP repeat VCBS PF13517.6 ELR20294.1 - 0.029 15.0 0.0 0.074 13.7 0.0 1.8 1 0 0 1 1 1 0 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella PliI PF16743.5 ELR20294.1 - 0.045 13.5 0.0 0.11 12.2 0.0 1.6 1 0 0 1 1 1 0 Periplasmic lysozyme inhibitor of I-type lysozyme EGF PF00008.27 ELR20296.1 - 0.0062 16.8 6.7 0.015 15.6 6.7 1.6 1 0 0 1 1 1 1 EGF-like domain PMP1_2 PF08114.11 ELR20297.1 - 0.018 14.8 0.3 0.038 13.7 0.3 1.5 1 0 0 1 1 1 0 ATPase proteolipid family Herpes_gE PF02480.16 ELR20297.1 - 0.022 13.5 0.0 0.028 13.2 0.0 1.1 1 0 0 1 1 1 0 Alphaherpesvirus glycoprotein E DUF3318 PF11780.8 ELR20297.1 - 0.1 12.6 0.7 0.16 11.9 0.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3318) RCC1_2 PF13540.6 ELR20298.1 - 1.1e-07 31.4 35.7 0.00057 19.6 0.2 8.3 9 0 0 9 9 9 4 Regulator of chromosome condensation (RCC1) repeat MgtC PF02308.16 ELR20298.1 - 0.0058 17.0 0.3 0.013 15.9 0.3 1.6 1 0 0 1 1 1 1 MgtC family VCBS PF13517.6 ELR20301.1 - 2.5e-07 31.2 3.4 0.0027 18.3 2.0 3.6 2 1 1 3 3 3 2 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella Gal_Lectin PF02140.18 ELR20301.1 - 2.3e-06 27.9 0.1 2.3e-06 27.9 0.1 2.6 3 0 0 3 3 3 1 Galactose binding lectin domain EGF PF00008.27 ELR20301.1 - 0.02 15.2 4.9 0.058 13.7 4.9 1.9 1 0 0 1 1 1 0 EGF-like domain CpeS PF09367.10 ELR20301.1 - 0.13 12.2 0.0 0.61 10.0 0.0 2.0 2 0 0 2 2 2 0 CpeS-like protein WAK_assoc PF14380.6 ELR20301.1 - 0.31 11.8 3.3 17 6.2 1.9 2.6 2 0 0 2 2 2 0 Wall-associated receptor kinase C-terminal Cation_ATPase_C PF00689.21 ELR20302.1 - 1.4e-46 158.5 5.1 6.7e-46 156.3 2.1 2.6 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus E1-E2_ATPase PF00122.20 ELR20302.1 - 1.7e-30 105.9 0.1 1.7e-30 105.9 0.1 2.9 4 0 0 4 4 4 1 E1-E2 ATPase Cation_ATPase PF13246.6 ELR20302.1 - 6e-24 83.9 0.0 1.2e-23 83.0 0.0 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 ELR20302.1 - 2.4e-19 70.4 0.1 5.9e-19 69.2 0.1 1.7 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 ELR20302.1 - 1.6e-09 37.3 0.0 3.5e-09 36.2 0.0 1.6 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 ELR20302.1 - 0.0012 18.6 0.3 0.045 13.5 0.2 2.3 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase S_4TM PF18159.1 ELR20302.1 - 0.37 10.0 1.9 7.2 5.8 0.6 2.5 2 0 0 2 2 2 0 SMODS-associating 4TM effector domain EI24 PF07264.11 ELR20302.1 - 0.86 9.8 6.5 4.4 7.5 0.2 3.5 3 1 0 3 3 3 0 Etoposide-induced protein 2.4 (EI24) DPM2 PF07297.12 ELR20302.1 - 4 7.8 7.0 0.94 9.8 1.9 2.5 2 0 0 2 2 2 0 Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2) Pestivirus_E2 PF16329.5 ELR20303.1 - 0.08 11.8 0.0 0.12 11.2 0.0 1.2 1 0 0 1 1 1 0 Pestivirus envelope glycoprotein E2 Mei5 PF10376.9 ELR20304.1 - 6e-09 36.1 2.9 6.8e-09 35.9 2.9 1.0 1 0 0 1 1 1 1 Double-strand recombination repair protein HSR PF03172.13 ELR20304.1 - 0.002 18.2 0.5 0.0025 17.9 0.5 1.1 1 0 0 1 1 1 1 HSR domain CCDC-167 PF15188.6 ELR20304.1 - 4.6 7.6 10.2 0.47 10.8 2.7 2.1 1 1 1 2 2 2 0 Coiled-coil domain-containing protein 167 Pkinase PF00069.25 ELR20305.1 - 9e-64 215.4 0.0 1.1e-63 215.1 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR20305.1 - 2.2e-38 132.0 0.0 3e-38 131.6 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ELR20305.1 - 6.2e-10 38.9 0.0 1.4e-09 37.7 0.0 1.4 1 1 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 ELR20305.1 - 0.001 17.9 0.0 0.0015 17.4 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase RIO1 PF01163.22 ELR20305.1 - 0.0025 17.5 0.1 0.0058 16.3 0.0 1.5 1 1 0 2 2 2 1 RIO1 family APH PF01636.23 ELR20305.1 - 0.0059 16.6 0.4 0.018 15.0 0.0 1.9 2 1 0 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.14 ELR20305.1 - 0.013 14.9 0.0 0.019 14.3 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 ELR20305.1 - 0.026 13.5 0.2 0.051 12.5 0.2 1.6 1 1 0 1 1 1 0 Haspin like kinase domain PIP49_C PF12260.8 ELR20305.1 - 0.14 11.8 0.0 0.24 11.0 0.0 1.3 1 0 0 1 1 1 0 Protein-kinase domain of FAM69 NAGLU PF05089.12 ELR20307.1 - 8.2e-64 215.7 11.3 7.8e-62 209.1 11.3 2.8 1 1 0 1 1 1 1 Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain NAGLU_N PF12971.7 ELR20307.1 - 6e-23 80.4 0.0 1.2e-22 79.4 0.0 1.5 1 0 0 1 1 1 1 Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain Flavodoxin_NdrI PF07972.11 ELR20307.1 - 0.077 13.2 0.0 0.13 12.4 0.0 1.3 1 0 0 1 1 1 0 NrdI Flavodoxin like NAGLU PF05089.12 ELR20308.1 - 5.2e-133 443.1 2.4 8.1e-133 442.5 1.5 1.7 2 0 0 2 2 2 1 Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain NAGLU_C PF12972.7 ELR20308.1 - 1.3e-62 211.8 5.1 1.8e-62 211.3 5.1 1.2 1 0 0 1 1 1 1 Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain NAGLU_N PF12971.7 ELR20308.1 - 8e-22 76.8 0.0 2e-21 75.6 0.0 1.7 1 0 0 1 1 1 1 Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain Pkinase PF00069.25 ELR20309.1 - 1.2e-29 103.4 0.0 4.5e-29 101.6 0.0 2.0 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR20309.1 - 4.5e-13 49.1 0.0 1.1e-12 47.8 0.0 1.7 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 ELR20309.1 - 7.6e-05 22.7 0.1 7.6e-05 22.7 0.1 2.9 3 1 0 3 3 3 1 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 ELR20309.1 - 0.00077 18.3 0.4 0.004 16.0 0.0 2.2 3 0 0 3 3 3 1 Fungal protein kinase Seadorna_VP7 PF07387.11 ELR20309.1 - 0.0021 17.2 0.1 0.011 14.9 0.0 2.0 2 0 0 2 2 2 1 Seadornavirus VP7 Ribonuc_2-5A PF06479.12 ELR20309.1 - 0.025 14.8 0.2 0.079 13.1 0.2 1.8 1 1 0 1 1 1 0 Ribonuclease 2-5A Haspin_kinase PF12330.8 ELR20309.1 - 0.084 11.8 0.0 0.084 11.8 0.0 1.5 2 0 0 2 2 2 0 Haspin like kinase domain Nudix_hydro PF18290.1 ELR20310.1 - 1.1e-30 105.4 0.0 2.1e-30 104.5 0.0 1.5 1 0 0 1 1 1 1 Nudix hydrolase domain NUDIX PF00293.28 ELR20310.1 - 1.5e-15 57.4 0.0 2.2e-15 56.8 0.0 1.3 1 0 0 1 1 1 1 NUDIX domain zf-RING_2 PF13639.6 ELR20311.1 - 2.4e-14 53.4 7.0 4.7e-14 52.4 7.0 1.5 1 0 0 1 1 1 1 Ring finger domain zf-RING_11 PF17123.5 ELR20311.1 - 3.7e-10 39.3 2.7 8.1e-10 38.3 2.7 1.6 1 0 0 1 1 1 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 ELR20311.1 - 1.6e-09 37.4 7.2 3.2e-09 36.5 7.2 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) SAM_1 PF00536.30 ELR20311.1 - 9.5e-09 35.6 0.0 3.2e-08 33.9 0.0 1.9 2 0 0 2 2 1 1 SAM domain (Sterile alpha motif) zf-C3HC4 PF00097.25 ELR20311.1 - 1.9e-07 30.8 6.0 3.7e-07 29.9 6.0 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 ELR20311.1 - 3e-07 30.3 2.7 6.8e-07 29.2 2.7 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-rbx1 PF12678.7 ELR20311.1 - 4.4e-07 30.1 8.6 4.4e-07 30.1 8.6 2.1 2 1 0 2 2 1 1 RING-H2 zinc finger domain zf-C3HC4_3 PF13920.6 ELR20311.1 - 3.8e-06 26.7 4.2 6.7e-06 25.9 4.2 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) SAM_2 PF07647.17 ELR20311.1 - 6.7e-06 26.1 0.0 1.5e-05 25.0 0.0 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) zf-RING_5 PF14634.6 ELR20311.1 - 7.5e-06 25.8 5.8 1.4e-05 24.9 5.8 1.5 1 0 0 1 1 1 1 zinc-RING finger domain Prok-RING_4 PF14447.6 ELR20311.1 - 0.00052 19.8 4.4 0.00092 19.0 4.4 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-ANAPC11 PF12861.7 ELR20311.1 - 0.0007 19.6 2.9 0.0017 18.4 2.9 1.7 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger Zn_ribbon_17 PF17120.5 ELR20311.1 - 0.00091 18.8 7.7 0.0021 17.6 7.7 1.6 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type RTX PF02382.15 ELR20311.1 - 0.0026 17.5 0.2 0.0045 16.7 0.2 1.3 1 0 0 1 1 1 1 N-terminal domain in RTX protein zf-RING-like PF08746.11 ELR20311.1 - 0.014 15.7 7.3 0.034 14.5 7.3 1.7 1 0 0 1 1 1 0 RING-like domain SAM_PNT PF02198.16 ELR20311.1 - 0.018 15.0 0.0 0.042 13.8 0.0 1.6 1 0 0 1 1 1 0 Sterile alpha motif (SAM)/Pointed domain zf-RING_9 PF13901.6 ELR20311.1 - 0.045 13.7 7.3 0.12 12.3 7.3 1.8 1 1 0 1 1 1 0 Putative zinc-RING and/or ribbon zf-C3H2C3 PF17122.5 ELR20311.1 - 0.08 13.0 2.3 0.19 11.8 2.3 1.6 1 0 0 1 1 1 0 Zinc-finger FANCL_C PF11793.8 ELR20311.1 - 0.1 12.8 4.5 0.28 11.4 4.5 1.8 1 1 0 1 1 1 0 FANCL C-terminal domain Zip PF02535.22 ELR20311.1 - 0.11 11.6 2.0 0.16 11.1 2.0 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter Gp138_N PF18352.1 ELR20311.1 - 0.13 12.3 0.1 0.36 10.9 0.1 1.7 1 0 0 1 1 1 0 Phage protein Gp138 N-terminal domain zf-Nse PF11789.8 ELR20311.1 - 0.14 12.0 4.0 0.31 10.9 4.0 1.6 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit RINGv PF12906.7 ELR20311.1 - 0.15 12.2 6.5 0.4 10.8 6.5 1.7 1 0 0 1 1 1 0 RING-variant domain zf-RING_4 PF14570.6 ELR20311.1 - 0.38 10.6 4.5 0.8 9.5 4.5 1.5 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain UIM PF02809.20 ELR20311.1 - 0.44 10.6 8.4 0.14 12.1 0.9 2.9 2 0 0 2 2 2 0 Ubiquitin interaction motif PHD PF00628.29 ELR20311.1 - 1.6 8.7 8.4 1.1 9.2 6.6 1.7 2 0 0 2 2 1 0 PHD-finger Prok-RING_1 PF14446.6 ELR20311.1 - 4.4 7.3 7.7 3.8 7.5 2.0 2.4 1 1 1 2 2 2 0 Prokaryotic RING finger family 1 TIG PF01833.24 ELR20312.1 - 7.6e-08 32.3 0.5 2.3e-07 30.8 0.5 1.8 1 1 0 1 1 1 1 IPT/TIG domain ubiquitin PF00240.23 ELR20312.1 - 1.7e-06 27.7 0.0 4.3e-05 23.2 0.0 2.2 2 0 0 2 2 2 1 Ubiquitin family YukD PF08817.10 ELR20312.1 - 0.0084 16.8 1.6 0.027 15.1 0.3 2.5 2 1 0 2 2 2 1 WXG100 protein secretion system (Wss), protein YukD GRIP PF01465.20 ELR20312.1 - 0.19 11.6 0.1 1.7 8.7 0.0 2.1 2 0 0 2 2 2 0 GRIP domain SPRY PF00622.28 ELR20314.1 - 1.3e-22 80.2 0.1 2.3e-22 79.3 0.1 1.5 1 0 0 1 1 1 1 SPRY domain zf-C3HC4_3 PF13920.6 ELR20314.1 - 1.9e-06 27.6 2.4 4.1e-06 26.6 2.4 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 ELR20314.1 - 0.006 16.4 4.7 0.016 15.0 4.7 1.7 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 Ras_bdg_2 PF14847.6 ELR20314.1 - 0.19 12.1 0.0 12 6.3 0.0 2.4 2 0 0 2 2 2 0 Ras-binding domain of Byr2 DNA_pol_A PF00476.20 ELR20315.1 - 6.8e-75 252.5 0.0 4.9e-74 249.6 0.0 2.2 2 1 0 2 2 2 1 DNA polymerase family A 5_3_exonuc_N PF02739.16 ELR20315.1 - 2.1e-41 141.5 0.0 3.7e-41 140.7 0.0 1.4 1 0 0 1 1 1 1 5'-3' exonuclease, N-terminal resolvase-like domain 5_3_exonuc PF01367.20 ELR20315.1 - 2.2e-28 98.7 0.1 7.8e-28 96.9 0.0 2.0 2 0 0 2 2 2 1 5'-3' exonuclease, C-terminal SAM fold DNA_pol_A_exo1 PF01612.20 ELR20315.1 - 3.3e-11 43.2 0.0 5.9e-11 42.4 0.0 1.5 1 0 0 1 1 1 1 3'-5' exonuclease HHH_5 PF14520.6 ELR20315.1 - 8e-05 23.2 0.0 0.00026 21.5 0.0 1.9 1 0 0 1 1 1 1 Helix-hairpin-helix domain HHH_2 PF12826.7 ELR20315.1 - 0.025 14.7 0.0 0.066 13.3 0.0 1.7 1 0 0 1 1 1 0 Helix-hairpin-helix motif HHH PF00633.23 ELR20315.1 - 0.03 14.2 0.8 0.091 12.7 0.3 2.1 2 0 0 2 2 2 0 Helix-hairpin-helix motif Bax1-I PF01027.20 ELR20316.1 - 2.3e-38 132.1 17.4 2.3e-38 132.1 17.4 1.8 2 0 0 2 2 2 1 Inhibitor of apoptosis-promoting Bax1 Peptidase_C2 PF00648.21 ELR20317.1 - 1.4e-39 135.9 0.0 2.2e-39 135.3 0.0 1.2 1 0 0 1 1 1 1 Calpain family cysteine protease WWE PF02825.20 ELR20317.1 - 7.5e-09 36.1 0.2 7.5e-09 36.1 0.2 2.2 2 0 0 2 2 2 1 WWE domain Mitofilin PF09731.9 ELR20317.1 - 3.1 6.5 7.5 4.3 6.1 7.5 1.1 1 0 0 1 1 1 0 Mitochondrial inner membrane protein PEMT PF04191.13 ELR20318.1 - 0.013 15.8 0.2 0.013 15.8 0.2 1.8 2 0 0 2 2 2 0 Phospholipid methyltransferase TMEM61 PF15105.6 ELR20318.1 - 0.5 10.2 2.8 0.23 11.3 0.3 1.7 2 0 0 2 2 2 0 TMEM61 protein family SAP PF02037.27 ELR20320.1 - 2.3e-07 30.4 0.0 2.3e-07 30.4 0.0 3.3 4 0 0 4 4 4 1 SAP domain Rho_N PF07498.12 ELR20320.1 - 0.029 14.3 8.2 0.4 10.6 0.2 4.3 5 0 0 5 5 5 0 Rho termination factor, N-terminal domain DUF4049 PF13258.6 ELR20322.1 - 0.067 12.3 0.0 0.072 12.1 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4049) GATase_3 PF07685.14 ELR20322.1 - 0.17 11.5 0.0 0.22 11.1 0.0 1.2 1 0 0 1 1 1 0 CobB/CobQ-like glutamine amidotransferase domain PhyH PF05721.13 ELR20323.1 - 0.00097 19.5 0.0 1.2 9.4 0.0 2.2 1 1 1 2 2 2 2 Phytanoyl-CoA dioxygenase (PhyH) 2OG-FeII_Oxy_2 PF13532.6 ELR20323.1 - 0.002 18.4 0.1 0.027 14.6 0.0 2.1 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily Aminotran_1_2 PF00155.21 ELR20324.1 - 1.1e-49 169.5 0.0 1.4e-49 169.2 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II HAD_2 PF13419.6 ELR20324.1 - 8.7e-26 91.1 0.0 2.2e-25 89.7 0.0 1.7 2 0 0 2 2 2 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 ELR20324.1 - 1.9e-12 47.9 0.1 1.6e-10 41.6 0.1 2.4 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 ELR20324.1 - 5.5e-08 33.4 0.1 7.4e-07 29.8 0.1 2.6 2 1 0 2 2 2 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 ELR20324.1 - 7.2e-05 22.8 0.1 0.00023 21.2 0.1 1.9 1 0 0 1 1 1 1 HAD-hyrolase-like Alliinase_C PF04864.13 ELR20324.1 - 0.00034 19.6 0.0 0.00053 19.0 0.0 1.2 1 0 0 1 1 1 1 Allinase Aminotran_MocR PF12897.7 ELR20324.1 - 0.045 12.5 0.1 0.086 11.6 0.1 1.3 1 0 0 1 1 1 0 Alanine-glyoxylate amino-transferase Cys_Met_Meta_PP PF01053.20 ELR20324.1 - 0.21 10.1 0.0 0.31 9.5 0.0 1.2 1 0 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme Hydrolase_3 PF08282.12 ELR20324.1 - 0.21 11.3 0.1 0.82 9.3 0.0 2.0 3 0 0 3 3 3 0 haloacid dehalogenase-like hydrolase Yip1 PF04893.17 ELR20325.1 - 4.1e-13 49.4 16.4 4.3e-13 49.3 15.2 1.6 1 1 1 2 2 2 1 Yip1 domain DUF456 PF04306.13 ELR20325.1 - 0.0089 16.3 9.5 0.0091 16.3 2.1 2.2 1 1 0 2 2 2 2 Protein of unknown function (DUF456) ATP1G1_PLM_MAT8 PF02038.16 ELR20325.1 - 2.3 7.7 6.2 12 5.5 0.0 3.0 3 0 0 3 3 3 0 ATP1G1/PLM/MAT8 family WD40 PF00400.32 ELR20327.1 - 1.1e-11 45.0 19.0 0.058 14.3 0.4 7.6 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ELR20327.1 - 0.0025 18.0 0.3 1.3 9.3 0.0 3.6 2 1 1 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain SIKE PF05769.11 ELR20327.1 - 0.016 15.1 0.0 0.049 13.6 0.0 1.8 1 0 0 1 1 1 0 SIKE family BBS2_Mid PF14783.6 ELR20327.1 - 0.16 12.0 0.0 1 9.4 0.0 2.3 3 0 0 3 3 3 0 Ciliary BBSome complex subunit 2, middle region Elongin_A PF06881.11 ELR20327.1 - 0.17 12.4 3.3 0.39 11.3 3.3 1.6 1 0 0 1 1 1 0 RNA polymerase II transcription factor SIII (Elongin) subunit A SH3_2 PF07653.17 ELR20328.1 - 0.15 11.7 0.0 0.33 10.7 0.0 1.6 1 0 0 1 1 1 0 Variant SH3 domain Atrophin-1 PF03154.15 ELR20328.1 - 7.9 4.6 6.8 11 4.1 6.8 1.1 1 0 0 1 1 1 0 Atrophin-1 family Sporozoite_P67 PF05642.11 ELR20329.1 - 7.2 4.6 6.5 24 2.8 0.0 2.0 2 0 0 2 2 2 0 Sporozoite P67 surface antigen SNF2_N PF00176.23 ELR20330.1 - 2e-17 63.0 0.1 4.3e-17 61.9 0.0 1.5 2 0 0 2 2 2 1 SNF2 family N-terminal domain Helicase_C PF00271.31 ELR20330.1 - 6.1e-13 49.1 0.0 1.6e-12 47.8 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ERCC3_RAD25_C PF16203.5 ELR20330.1 - 0.12 11.6 0.0 0.12 11.6 0.0 1.7 2 0 0 2 2 2 0 ERCC3/RAD25/XPB C-terminal helicase DUF2336 PF10098.9 ELR20331.1 - 0.046 13.2 0.1 0.11 12.0 0.1 1.6 1 1 0 1 1 1 0 Uncharacterised protein conserved in bacteria (DUF2336) Carb_anhydrase PF00194.21 ELR20332.1 - 6.4e-38 130.7 2.1 1.3e-37 129.8 2.1 1.5 1 1 0 1 1 1 1 Eukaryotic-type carbonic anhydrase IGPD PF00475.18 ELR20334.1 - 1.2e-62 210.4 0.5 1.6e-62 210.0 0.5 1.2 1 0 0 1 1 1 1 Imidazoleglycerol-phosphate dehydratase LIM PF00412.22 ELR20335.1 - 5.2e-22 77.8 15.8 1.5e-11 44.4 0.6 3.3 3 1 1 4 4 4 2 LIM domain zinc_ribbon_2 PF13240.6 ELR20335.1 - 1.1e-06 28.2 5.0 1.1e-06 28.2 5.0 5.4 7 0 0 7 7 7 1 zinc-ribbon domain DZR PF12773.7 ELR20335.1 - 2.4e-05 24.3 0.7 2.4e-05 24.3 0.7 4.6 2 1 0 2 2 2 1 Double zinc ribbon zf-dskA_traR PF01258.17 ELR20335.1 - 0.00013 21.8 24.3 0.0019 18.1 1.4 6.4 4 2 2 6 6 6 2 Prokaryotic dksA/traR C4-type zinc finger zf-ribbon_3 PF13248.6 ELR20335.1 - 0.0072 15.7 4.3 0.0072 15.7 4.3 5.1 7 0 0 7 7 7 1 zinc-ribbon domain zinc_ribbon_15 PF17032.5 ELR20335.1 - 0.039 14.7 1.9 0.039 14.7 1.9 4.1 4 1 0 4 4 4 0 zinc-ribbon family DUF2116 PF09889.9 ELR20335.1 - 0.062 13.3 1.3 0.062 13.3 1.3 2.9 3 0 0 3 3 3 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) zinc_ribbon_2 PF13240.6 ELR20336.1 - 1.8e-07 30.7 5.0 2.8e-07 30.1 5.0 1.3 1 0 0 1 1 1 1 zinc-ribbon domain DZR PF12773.7 ELR20336.1 - 4.3e-06 26.7 0.9 5.6e-06 26.3 0.9 1.2 1 0 0 1 1 1 1 Double zinc ribbon zf-NADH-PPase PF09297.11 ELR20336.1 - 0.00026 20.6 9.6 0.019 14.6 2.7 2.2 1 1 1 2 2 2 2 NADH pyrophosphatase zinc ribbon domain zf-ribbon_3 PF13248.6 ELR20336.1 - 0.0011 18.3 4.3 0.0018 17.6 4.3 1.4 1 0 0 1 1 1 1 zinc-ribbon domain Nudix_N_2 PF14803.6 ELR20336.1 - 0.0025 17.7 3.7 0.72 9.8 0.3 2.3 2 0 0 2 2 2 2 Nudix N-terminal zinc_ribbon_15 PF17032.5 ELR20336.1 - 0.0076 17.0 1.9 0.01 16.6 1.9 1.2 1 0 0 1 1 1 1 zinc-ribbon family DUF2116 PF09889.9 ELR20336.1 - 0.01 15.8 1.1 0.014 15.4 1.1 1.2 1 0 0 1 1 1 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) UPF0547 PF10571.9 ELR20336.1 - 0.038 14.1 4.4 0.078 13.1 4.4 1.5 1 1 0 1 1 1 0 Uncharacterised protein family UPF0547 DUF35_N PF12172.8 ELR20336.1 - 0.072 13.0 4.5 0.12 12.3 4.5 1.3 1 0 0 1 1 1 0 Rubredoxin-like zinc ribbon domain (DUF35_N) DHHC PF01529.20 ELR20336.1 - 0.11 12.6 0.2 0.14 12.3 0.2 1.1 1 0 0 1 1 1 0 DHHC palmitoyltransferase zf-dskA_traR PF01258.17 ELR20336.1 - 0.49 10.4 2.3 14 5.7 0.1 2.2 1 1 1 2 2 2 0 Prokaryotic dksA/traR C4-type zinc finger Herpes_capsid PF06112.11 ELR20336.1 - 1.7 8.7 10.1 1.9 8.5 10.1 1.2 1 0 0 1 1 1 0 Gammaherpesvirus capsid protein NOB1_Zn_bind PF08772.11 ELR20336.1 - 2.7 8.2 5.3 30 4.9 5.3 2.1 1 1 0 1 1 1 0 Nin one binding (NOB1) Zn-ribbon like Pkinase_Tyr PF07714.17 ELR20338.1 - 3.3e-64 216.7 0.0 4.5e-64 216.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ELR20338.1 - 2e-56 191.3 0.0 2.8e-56 190.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Guanylate_cyc PF00211.20 ELR20338.1 - 2.4e-16 59.9 0.0 3.9e-16 59.2 0.0 1.2 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain APH PF01636.23 ELR20338.1 - 6.6e-05 22.9 1.8 8.7e-05 22.6 0.1 2.0 2 1 1 3 3 3 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 ELR20338.1 - 0.0018 17.3 0.0 0.0031 16.5 0.0 1.4 1 0 0 1 1 1 1 Haspin like kinase domain DUF4166 PF13761.6 ELR20338.1 - 0.092 12.5 0.1 0.27 11.0 0.1 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4166) Seadorna_VP7 PF07387.11 ELR20338.1 - 0.15 11.0 0.0 0.24 10.4 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 Acetyltransf_6 PF13480.7 ELR20339.1 - 0.00024 21.3 6.3 0.0096 16.1 1.9 2.9 2 0 0 2 2 2 2 Acetyltransferase (GNAT) domain Hid1 PF12722.7 ELR20341.1 - 0.54 8.3 7.8 0.61 8.1 7.8 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein BUD22 PF09073.10 ELR20341.1 - 1.4 8.2 27.3 1.8 7.8 27.3 1.1 1 0 0 1 1 1 0 BUD22 PKD PF00801.20 ELR20342.1 - 2.5e-09 36.8 1.7 1.2e-08 34.7 0.1 2.8 3 0 0 3 3 3 1 PKD domain SRAP PF02586.14 ELR20343.1 - 3e-60 203.5 0.0 4.3e-60 203.0 0.0 1.1 1 0 0 1 1 1 1 SOS response associated peptidase (SRAP) FYVE PF01363.21 ELR20344.1 - 2.5e-19 69.1 12.1 4.9e-19 68.2 12.1 1.5 1 0 0 1 1 1 1 FYVE zinc finger Abhydrolase_1 PF00561.20 ELR20344.1 - 2.4e-18 66.7 0.1 1.6e-16 60.8 0.1 2.2 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 ELR20344.1 - 8.9e-18 64.4 0.0 1.3e-17 63.9 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 ELR20344.1 - 5.5e-14 53.3 0.0 7.2e-14 52.9 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family DLH PF01738.18 ELR20344.1 - 7.5e-07 28.9 0.9 0.00015 21.4 0.3 3.4 2 2 1 3 3 3 1 Dienelactone hydrolase family Peptidase_S9 PF00326.21 ELR20344.1 - 7.7e-05 22.3 0.8 0.0078 15.7 0.2 2.6 1 1 1 2 2 2 1 Prolyl oligopeptidase family Thioesterase PF00975.20 ELR20344.1 - 0.0019 18.3 2.0 0.0031 17.7 0.2 2.1 2 0 0 2 2 2 1 Thioesterase domain Ndr PF03096.14 ELR20344.1 - 0.0021 16.8 0.0 0.0035 16.1 0.0 1.2 1 0 0 1 1 1 1 Ndr family Abhydrolase_5 PF12695.7 ELR20344.1 - 0.0036 17.1 0.0 0.0071 16.1 0.0 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_2 PF02230.16 ELR20344.1 - 0.016 15.0 0.1 0.11 12.3 0.0 2.1 1 1 1 2 2 2 0 Phospholipase/Carboxylesterase Esterase PF00756.20 ELR20344.1 - 0.026 14.2 1.4 0.026 14.1 0.0 1.7 2 0 0 2 2 2 0 Putative esterase PGAP1 PF07819.13 ELR20344.1 - 0.027 14.2 0.1 0.32 10.7 0.1 2.2 1 1 1 2 2 2 0 PGAP1-like protein UPF0227 PF05728.12 ELR20344.1 - 0.054 13.4 0.0 0.11 12.4 0.0 1.5 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0227) IBR PF01485.21 ELR20344.1 - 7.1 6.9 15.4 1.3 9.3 11.3 1.9 1 1 1 2 2 2 0 IBR domain, a half RING-finger domain SAPS PF04499.15 ELR20344.1 - 9.3 4.9 13.3 13 4.4 9.5 2.1 2 0 0 2 2 2 0 SIT4 phosphatase-associated protein EF-hand_7 PF13499.6 ELR20345.1 - 3.3e-14 53.1 5.0 3.2e-07 30.7 1.0 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 ELR20345.1 - 7.6e-14 50.4 3.5 1.5e-05 24.5 0.6 3.3 3 0 0 3 3 3 2 EF-hand domain EF-hand_1 PF00036.32 ELR20345.1 - 2.9e-13 48.4 3.5 1.4e-05 24.3 0.3 3.3 3 0 0 3 3 3 2 EF hand EF-hand_5 PF13202.6 ELR20345.1 - 4.3e-12 44.9 1.8 4.1e-05 22.9 0.1 2.7 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 ELR20345.1 - 1.8e-05 24.5 2.1 0.016 15.1 0.0 3.4 2 1 2 4 4 4 2 EF-hand domain pair EF-hand_9 PF14658.6 ELR20345.1 - 0.0015 18.8 0.1 0.098 13.0 0.1 2.2 2 0 0 2 2 2 1 EF-hand domain Nif11 PF07862.11 ELR20345.1 - 0.0038 17.5 1.1 0.011 16.1 0.2 2.1 2 0 0 2 2 2 1 Nif11 domain SPARC_Ca_bdg PF10591.9 ELR20345.1 - 0.017 15.4 1.1 1.6 9.0 0.1 2.2 1 1 1 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_10 PF14788.6 ELR20345.1 - 0.32 10.9 1.9 3.5 7.6 0.0 2.6 3 0 0 3 3 3 0 EF hand EF-hand_1 PF00036.32 ELR20346.1 - 3.4e-13 48.1 0.2 4.2e-07 29.0 0.0 2.2 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 ELR20346.1 - 2.6e-11 43.8 0.5 3.2e-11 43.5 0.5 1.1 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.6 ELR20346.1 - 5.5e-11 42.2 0.5 6.9e-06 25.8 0.1 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 ELR20346.1 - 1.1e-10 40.5 0.2 0.0001 22.0 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.6 ELR20346.1 - 8.3e-10 37.7 0.7 6.2e-05 22.3 0.0 2.3 2 0 0 2 2 2 2 EF hand EF-hand_10 PF14788.6 ELR20346.1 - 0.012 15.5 0.6 0.042 13.7 0.1 2.0 1 1 1 2 2 2 0 EF hand EF-hand_4 PF12763.7 ELR20346.1 - 0.047 13.6 1.5 0.74 9.8 0.1 2.0 1 1 1 2 2 2 0 Cytoskeletal-regulatory complex EF hand YusW PF14039.6 ELR20346.1 - 0.06 13.9 0.2 0.071 13.6 0.2 1.1 1 0 0 1 1 1 0 YusW-like protein PMBR PF09373.10 ELR20346.1 - 0.18 12.0 0.0 5.5 7.3 0.0 2.2 2 0 0 2 2 2 0 Pseudomurein-binding repeat Lipocalin_4 PF13648.6 ELR20347.1 - 0.087 13.8 0.6 0.14 13.2 0.6 1.3 1 0 0 1 1 1 0 Lipocalin-like domain PARG_cat PF05028.14 ELR20349.1 - 1e-89 301.2 0.0 1.3e-89 300.8 0.0 1.0 1 0 0 1 1 1 1 Poly (ADP-ribose) glycohydrolase (PARG) BLM10_mid PF16507.5 ELR20350.1 - 2.8e-46 158.3 0.1 4.7e-46 157.5 0.1 1.3 1 0 0 1 1 1 1 Proteasome-substrate-size regulator, mid region DUF3437 PF11919.8 ELR20350.1 - 1.3e-24 85.9 2.0 2.3e-23 81.9 0.1 3.7 3 0 0 3 3 3 1 Domain of unknown function (DUF3437) CLASP_N PF12348.8 ELR20350.1 - 4.6e-08 32.9 0.9 0.078 12.5 0.0 5.3 5 0 0 5 5 5 3 CLASP N terminal GDH_N PF12466.8 ELR20350.1 - 0.017 15.3 0.8 0.078 13.2 0.3 2.4 2 0 0 2 2 2 0 Glutamate dehydrogenase N terminal Glypican PF01153.19 ELR20350.1 - 0.078 11.8 0.3 0.22 10.3 0.3 1.7 1 0 0 1 1 1 0 Glypican Acetyltransf_7 PF13508.7 ELR20351.1 - 7e-07 29.6 0.0 9e-07 29.2 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 ELR20351.1 - 1.1e-06 28.7 0.0 1.2e-06 28.4 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 ELR20351.1 - 5.7e-05 23.3 0.1 6.7e-05 23.1 0.1 1.3 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family FR47 PF08445.10 ELR20351.1 - 0.0013 18.7 0.0 0.002 18.0 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein DUF393 PF04134.12 ELR20352.1 - 2.1e-27 96.7 0.1 2.3e-27 96.6 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function, DUF393 AhpC-TSA PF00578.21 ELR20352.1 - 0.037 13.9 0.0 0.052 13.5 0.0 1.2 1 0 0 1 1 1 0 AhpC/TSA family eIF-5a PF01287.20 ELR20352.1 - 0.15 12.2 0.7 0.26 11.4 0.7 1.4 1 1 0 1 1 1 0 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold Ank_4 PF13637.6 ELR20353.1 - 2.4e-19 69.4 2.5 5.5e-13 49.2 0.1 3.0 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 ELR20353.1 - 1.5e-17 63.9 0.3 4.9e-07 30.2 0.2 3.5 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) BTB PF00651.31 ELR20353.1 - 4.5e-16 59.1 0.1 8.3e-16 58.2 0.1 1.4 1 0 0 1 1 1 1 BTB/POZ domain Ank PF00023.30 ELR20353.1 - 8.3e-15 54.5 9.2 1.8e-06 28.1 0.2 4.2 4 0 0 4 4 4 3 Ankyrin repeat Ank_3 PF13606.6 ELR20353.1 - 1.4e-12 46.6 2.6 0.00017 21.8 0.0 4.3 3 0 0 3 3 3 3 Ankyrin repeat Ank_5 PF13857.6 ELR20353.1 - 1.4e-10 41.2 3.2 0.00091 19.5 0.2 3.7 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Patatin PF01734.22 ELR20353.1 - 1.9e-05 25.0 0.3 0.00024 21.4 0.2 2.7 2 1 0 2 2 2 1 Patatin-like phospholipase DUF393 PF04134.12 ELR20354.1 - 1.8e-07 32.5 0.2 2.6e-07 32.0 0.2 1.3 1 0 0 1 1 1 1 Protein of unknown function, DUF393 AhpC-TSA PF00578.21 ELR20354.1 - 0.062 13.2 0.0 0.073 13.0 0.0 1.1 1 0 0 1 1 1 0 AhpC/TSA family TraF PF13728.6 ELR20354.1 - 0.17 11.7 0.0 0.19 11.5 0.0 1.1 1 0 0 1 1 1 0 F plasmid transfer operon protein Peptidase_S74 PF13884.6 ELR20355.1 - 2.4e-13 50.2 0.1 4.8e-13 49.2 0.1 1.6 1 0 0 1 1 1 1 Chaperone of endosialidase TipAS PF07739.13 ELR20357.1 - 0.04 14.5 0.2 0.082 13.5 0.2 1.5 1 0 0 1 1 1 0 TipAS antibiotic-recognition domain p31comet PF06581.12 ELR20357.1 - 0.047 12.9 0.0 0.087 12.0 0.0 1.4 1 0 0 1 1 1 0 Mad1 and Cdc20-bound-Mad2 binding SAP PF02037.27 ELR20358.1 - 0.069 12.9 0.0 0.11 12.2 0.0 1.3 1 0 0 1 1 1 0 SAP domain HATPase_c PF02518.26 ELR20359.1 - 1.5e-25 89.8 0.0 3.1e-25 88.9 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 ELR20359.1 - 3.8e-25 88.2 0.3 1.2e-24 86.7 0.3 1.9 1 0 0 1 1 1 1 Response regulator receiver domain HisKA PF00512.25 ELR20359.1 - 6.6e-20 70.9 0.2 1.8e-19 69.5 0.2 1.9 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain GAF PF01590.26 ELR20359.1 - 3.1e-10 40.8 0.0 8e-10 39.5 0.0 1.8 1 0 0 1 1 1 1 GAF domain GAF_2 PF13185.6 ELR20359.1 - 6.4e-05 23.3 0.0 0.00018 21.8 0.0 1.9 1 0 0 1 1 1 1 GAF domain GAF_3 PF13492.6 ELR20359.1 - 0.0021 18.4 0.2 0.01 16.2 0.0 2.4 2 1 0 2 2 2 1 GAF domain SpoVT_C PF15714.5 ELR20359.1 - 0.0029 17.6 0.1 0.11 12.5 0.0 2.7 2 0 0 2 2 2 1 Stage V sporulation protein T C-terminal, transcription factor CREPT PF16566.5 ELR20359.1 - 0.005 17.0 1.8 0.014 15.5 1.8 1.7 1 0 0 1 1 1 1 Cell-cycle alteration and expression-elevated protein in tumour DSPc PF00782.20 ELR20360.1 - 3.5e-25 88.4 0.0 4.8e-25 87.9 0.0 1.2 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 ELR20360.1 - 0.007 16.0 0.0 0.011 15.4 0.0 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase DUF309 PF03745.14 ELR20360.1 - 0.032 13.9 0.0 0.12 12.1 0.0 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF309) Agenet PF05641.12 ELR20360.1 - 0.15 12.5 2.1 0.4 11.2 2.1 1.8 1 0 0 1 1 1 0 Agenet domain HATPase_c PF02518.26 ELR20361.1 - 1.2e-28 99.8 0.0 4.9e-28 97.9 0.0 1.9 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 ELR20361.1 - 2.3e-21 76.1 0.1 5.4e-21 74.9 0.0 1.7 2 0 0 2 2 2 1 Response regulator receiver domain HisKA PF00512.25 ELR20361.1 - 3.6e-12 46.1 0.5 1.1e-11 44.5 0.2 2.1 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain DUF3446 PF11928.8 ELR20361.1 - 0.036 14.4 1.3 0.036 14.4 1.3 3.8 4 0 0 4 4 4 0 Early growth response N-terminal domain PsbX PF06596.11 ELR20361.1 - 0.64 10.1 5.1 2.2 8.4 5.1 2.0 1 0 0 1 1 1 0 Photosystem II reaction centre X protein (PsbX) PTPLA PF04387.14 ELR20363.1 - 8.9e-20 71.1 19.2 1.5e-19 70.3 14.6 2.3 2 1 0 2 2 2 1 Protein tyrosine phosphatase-like protein, PTPLA HATPase_c PF02518.26 ELR20364.1 - 7.6e-25 87.6 0.0 1.5e-24 86.7 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 ELR20364.1 - 4.3e-24 84.8 0.2 1.2e-23 83.4 0.0 1.9 2 0 0 2 2 2 1 Response regulator receiver domain HisKA PF00512.25 ELR20364.1 - 1.9e-14 53.5 0.2 4.4e-14 52.2 0.2 1.7 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain PTPLA PF04387.14 ELR20365.1 - 3.8e-27 95.0 12.1 6.2e-27 94.4 12.1 1.3 1 0 0 1 1 1 1 Protein tyrosine phosphatase-like protein, PTPLA Response_reg PF00072.24 ELR20366.1 - 6.5e-08 32.7 0.0 0.00068 19.8 0.0 2.1 2 0 0 2 2 2 2 Response regulator receiver domain Ndc1_Nup PF09531.10 ELR20366.1 - 0.78 8.3 7.4 0.84 8.3 7.4 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup SPX PF03105.19 ELR20366.1 - 2.9 7.7 8.0 3.2 7.6 8.0 1.1 1 0 0 1 1 1 0 SPX domain Methyltransf_24 PF13578.6 ELR20367.1 - 1.3e-07 32.6 0.0 1.8e-07 32.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain PH PF00169.29 ELR20368.1 - 5.3e-18 65.5 0.3 2.8e-11 43.9 0.0 2.4 2 0 0 2 2 2 2 PH domain PH_13 PF16652.5 ELR20368.1 - 0.0029 17.4 0.1 0.022 14.6 0.0 2.1 2 0 0 2 2 2 1 Pleckstrin homology domain PH_11 PF15413.6 ELR20368.1 - 0.079 13.4 3.4 1.2 9.6 0.0 3.6 3 2 0 3 3 3 0 Pleckstrin homology domain SASRP1 PF15160.6 ELR20368.1 - 0.21 11.2 1.1 0.46 10.1 1.1 1.5 1 0 0 1 1 1 0 Spermatogenesis-associated serine-rich protein 1 LZ_Tnp_IS66 PF13007.7 ELR20368.1 - 0.5 11.2 2.4 3.9 8.3 0.5 2.5 2 0 0 2 2 2 0 Transposase C of IS166 homeodomain RhoGEF PF00621.20 ELR20369.1 - 2.9e-39 135.2 0.0 4.3e-39 134.6 0.0 1.2 1 0 0 1 1 1 1 RhoGEF domain Response_reg PF00072.24 ELR20369.1 - 1.8e-15 57.1 0.0 1.9e-09 37.7 0.1 2.5 2 0 0 2 2 2 2 Response regulator receiver domain RhoGEF PF00621.20 ELR20370.1 - 8.1e-13 49.0 1.8 1.2e-12 48.4 0.1 2.0 2 0 0 2 2 2 1 RhoGEF domain KLRAQ PF10205.9 ELR20370.1 - 0.006 16.8 1.3 0.006 16.8 1.3 2.6 2 0 0 2 2 2 1 Predicted coiled-coil domain-containing protein ATG16 PF08614.11 ELR20370.1 - 0.007 16.6 4.7 0.007 16.6 4.7 4.7 2 1 2 5 5 5 1 Autophagy protein 16 (ATG16) RhoGAP PF00620.27 ELR20371.1 - 1.8e-16 60.3 0.0 2.8e-16 59.7 0.0 1.2 1 0 0 1 1 1 1 RhoGAP domain Arf PF00025.21 ELR20372.1 - 1.6e-72 242.6 0.0 3.9e-45 153.4 0.0 3.3 2 1 1 3 3 3 3 ADP-ribosylation factor family Ras PF00071.22 ELR20372.1 - 4e-17 62.3 0.0 2.7e-11 43.4 0.0 2.2 2 0 0 2 2 2 2 Ras family Roc PF08477.13 ELR20372.1 - 5e-17 62.2 0.0 8.9e-10 38.8 0.0 2.3 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase LRR_4 PF12799.7 ELR20372.1 - 8.9e-11 41.9 8.2 0.03 14.7 0.0 4.7 3 1 1 4 4 4 4 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 ELR20372.1 - 1.6e-10 40.2 7.1 0.052 13.6 0.1 6.2 5 0 0 5 5 5 3 Leucine Rich repeat LRR_8 PF13855.6 ELR20372.1 - 1.3e-09 37.7 10.0 0.00032 20.4 1.9 3.2 2 1 1 3 3 3 3 Leucine rich repeat SRPRB PF09439.10 ELR20372.1 - 3.3e-09 36.4 0.0 0.0001 21.8 0.0 2.6 2 1 1 3 3 3 2 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 ELR20372.1 - 6.6e-06 25.7 0.0 0.0097 15.3 0.0 2.3 2 0 0 2 2 2 2 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 ELR20372.1 - 1e-05 25.6 0.0 0.016 15.3 0.0 2.5 2 0 0 2 2 2 2 50S ribosome-binding GTPase G-alpha PF00503.20 ELR20372.1 - 0.00012 21.4 3.2 0.0098 15.1 0.0 3.1 2 1 1 3 3 3 1 G-protein alpha subunit LRR_1 PF00560.33 ELR20372.1 - 0.0033 17.7 7.8 11 7.1 0.0 5.6 5 0 0 5 5 4 1 Leucine Rich Repeat AAA_33 PF13671.6 ELR20372.1 - 0.052 13.7 0.0 2.5 8.2 0.0 2.4 2 0 0 2 2 2 0 AAA domain PDCD2_C PF04194.13 ELR20373.1 - 1.1e-41 142.9 1.2 1.1e-41 142.9 1.2 1.7 2 0 0 2 2 2 1 Programmed cell death protein 2, C-terminal putative domain zf-MYND PF01753.18 ELR20373.1 - 2.1e-08 34.1 14.1 2.1e-08 34.1 14.1 2.8 2 1 0 2 2 2 1 MYND finger DZR PF12773.7 ELR20373.1 - 0.042 13.9 4.8 0.69 10.0 2.4 2.7 2 0 0 2 2 2 0 Double zinc ribbon RecR PF02132.15 ELR20373.1 - 0.07 12.7 4.3 1.6 8.4 1.6 2.6 2 0 0 2 2 2 0 RecR protein YdjO PF14169.6 ELR20373.1 - 0.095 12.5 6.2 0.15 11.8 0.1 3.2 4 0 0 4 4 4 0 Cold-inducible protein YdjO zf-RING_7 PF02591.15 ELR20373.1 - 0.64 10.3 6.6 7.2 6.9 0.1 3.8 4 0 0 4 4 4 0 C4-type zinc ribbon domain zf-ribbon_3 PF13248.6 ELR20373.1 - 1.2 8.6 8.3 9.8 5.7 0.7 3.5 3 0 0 3 3 3 0 zinc-ribbon domain zf-tcix PF14952.6 ELR20373.1 - 7.9 6.2 12.2 2.6 7.7 1.2 3.2 4 0 0 4 4 4 0 Putative treble-clef, zinc-finger, Zn-binding Xpo1 PF08389.12 ELR20374.1 - 1.6e-28 99.7 7.2 4e-28 98.3 0.4 3.6 3 0 0 3 3 3 1 Exportin 1-like protein IBN_N PF03810.19 ELR20374.1 - 0.00063 19.6 0.4 0.013 15.4 0.0 3.1 2 0 0 2 2 2 1 Importin-beta N-terminal domain STAG PF08514.11 ELR20374.1 - 0.011 15.6 0.2 0.087 12.7 0.1 2.6 2 0 0 2 2 2 0 STAG domain WGG PF10273.9 ELR20374.1 - 0.017 15.8 1.0 0.13 12.9 0.1 3.0 2 0 0 2 2 2 0 Pre-rRNA-processing protein TSR2 HBS1_N PF08938.10 ELR20374.1 - 0.077 13.3 0.1 5.9 7.3 0.3 3.2 2 0 0 2 2 2 0 HBS1 N-terminus DUF445 PF04286.12 ELR20374.1 - 0.082 12.7 0.5 0.41 10.4 0.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF445) NUC130_3NT PF08158.12 ELR20374.1 - 0.22 11.9 6.0 72 3.8 0.1 5.7 4 1 1 5 5 5 0 NUC130/3NT domain FA_desaturase PF00487.24 ELR20375.1 - 1.9e-27 96.7 26.7 1.9e-27 96.7 26.7 2.0 1 1 1 2 2 2 1 Fatty acid desaturase Cyt-b5 PF00173.28 ELR20375.1 - 4.6e-12 45.9 0.0 1e-11 44.8 0.0 1.5 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain FA_desaturase PF00487.24 ELR20376.1 - 1.1e-15 58.2 2.6 1.5e-15 57.7 2.6 1.2 1 0 0 1 1 1 1 Fatty acid desaturase GRASP55_65 PF04495.14 ELR20377.1 - 4e-31 108.2 0.0 8.5e-28 97.4 0.0 2.1 2 0 0 2 2 2 2 GRASP55/65 PDZ-like domain PDZ_6 PF17820.1 ELR20377.1 - 1.4e-06 28.1 0.2 0.0029 17.4 0.0 2.6 2 1 0 2 2 2 2 PDZ domain PDZ_2 PF13180.6 ELR20377.1 - 0.028 14.8 0.0 0.56 10.6 0.0 2.1 2 0 0 2 2 2 0 PDZ domain Pkinase PF00069.25 ELR20378.1 - 9.3e-68 228.4 0.0 1.2e-67 228.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR20378.1 - 2.3e-25 89.4 0.0 3.4e-25 88.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 ELR20378.1 - 0.0024 17.3 0.0 0.0035 16.7 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family FTA2 PF13095.6 ELR20378.1 - 0.0032 17.1 0.0 0.14 11.8 0.0 2.2 2 0 0 2 2 2 1 Kinetochore Sim4 complex subunit FTA2 RIO1 PF01163.22 ELR20378.1 - 0.0046 16.6 0.0 0.0078 15.8 0.0 1.3 1 0 0 1 1 1 1 RIO1 family Pkinase_fungal PF17667.1 ELR20378.1 - 0.04 12.7 0.0 0.06 12.1 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase CAP_N PF01213.19 ELR20380.1 - 0.7 9.3 11.1 0.73 9.3 11.1 1.0 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal SMN PF06003.12 ELR20380.1 - 0.89 8.8 9.8 0.89 8.8 9.8 1.1 1 0 0 1 1 1 0 Survival motor neuron protein (SMN) Dscam_C PF12355.8 ELR20380.1 - 3.2 8.8 11.4 3.4 8.7 11.4 1.1 1 0 0 1 1 1 0 Down syndrome cell adhesion molecule C terminal Mito_fiss_reg PF05308.11 ELR20380.1 - 9.4 6.2 11.1 9.6 6.2 11.1 1.1 1 0 0 1 1 1 0 Mitochondrial fission regulator Synapsin_C PF02750.14 ELR20381.1 - 3.2e-45 154.2 0.0 4.1e-45 153.8 0.0 1.1 1 0 0 1 1 1 1 Synapsin, ATP binding domain Synapsin PF02078.16 ELR20381.1 - 9.4e-18 64.4 0.0 1.9e-17 63.4 0.0 1.5 1 0 0 1 1 1 1 Synapsin, N-terminal domain ATPgrasp_YheCD PF14398.6 ELR20381.1 - 0.0015 17.9 0.0 0.0034 16.7 0.0 1.6 2 0 0 2 2 2 1 YheC/D like ATP-grasp ATPgrasp_ST PF14397.6 ELR20381.1 - 0.0058 15.9 0.0 0.0097 15.2 0.0 1.3 1 0 0 1 1 1 1 Sugar-transfer associated ATP-grasp DUF4907 PF16250.5 ELR20381.1 - 0.13 12.2 0.0 0.44 10.5 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4907) UDG PF03167.19 ELR20382.1 - 1.5e-21 77.0 0.0 3e-21 76.0 0.0 1.4 1 0 0 1 1 1 1 Uracil DNA glycosylase superfamily PARP_reg PF02877.14 ELR20382.1 - 2e-14 53.8 0.1 3.9e-14 52.9 0.1 1.4 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase, regulatory domain BRCT_2 PF16589.5 ELR20382.1 - 6.3e-08 32.9 0.0 1.3e-07 31.9 0.0 1.6 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain BRCT PF00533.26 ELR20382.1 - 0.00027 21.3 0.0 0.00054 20.3 0.0 1.6 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain WGR PF05406.15 ELR20382.1 - 0.00074 19.5 0.0 0.0018 18.3 0.0 1.6 1 0 0 1 1 1 1 WGR domain PTCB-BRCT PF12738.7 ELR20382.1 - 0.027 14.4 0.1 0.061 13.3 0.1 1.6 1 0 0 1 1 1 0 twin BRCT domain DUF1902 PF08972.11 ELR20382.1 - 0.06 13.3 0.2 0.06 13.3 0.2 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF1902) LIG3_BRCT PF16759.5 ELR20382.1 - 0.14 12.4 0.1 0.31 11.4 0.1 1.5 1 0 0 1 1 1 0 DNA ligase 3 BRCT domain DEK_C PF08766.11 ELR20383.1 - 0.0037 17.1 0.1 0.0065 16.4 0.1 1.4 1 0 0 1 1 1 1 DEK C terminal domain SAGA-Tad1 PF12767.7 ELR20383.1 - 0.21 11.3 5.7 0.24 11.1 5.7 1.1 1 0 0 1 1 1 0 Transcriptional regulator of RNA polII, SAGA, subunit SDA1 PF05285.12 ELR20383.1 - 0.28 10.6 20.5 0.33 10.3 20.5 1.0 1 0 0 1 1 1 0 SDA1 Trypan_PARP PF05887.11 ELR20383.1 - 0.52 10.3 13.9 0.69 9.9 13.9 1.1 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) CDC45 PF02724.14 ELR20383.1 - 3.6 5.8 18.3 4 5.6 18.3 1.0 1 0 0 1 1 1 0 CDC45-like protein RR_TM4-6 PF06459.12 ELR20383.1 - 3.6 7.3 16.2 4.7 6.9 16.2 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Spore_coat_CotO PF14153.6 ELR20383.1 - 6.5 6.6 21.0 9.6 6.1 21.0 1.2 1 0 0 1 1 1 0 Spore coat protein CotO PA26 PF04636.13 ELR20383.1 - 7.5 5.4 8.6 8.3 5.2 8.6 1.1 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Presenilin PF01080.17 ELR20383.1 - 8.6 5.0 13.1 9 4.9 13.1 1.1 1 0 0 1 1 1 0 Presenilin Glyco_transf_64 PF09258.10 ELR20384.1 - 3.5e-20 72.3 0.0 5.7e-20 71.6 0.0 1.3 1 1 0 1 1 1 1 Glycosyl transferase family 64 domain PAN_4 PF14295.6 ELR20385.1 - 1e-06 28.5 3.3 1.3e-06 28.2 3.3 1.2 1 0 0 1 1 1 1 PAN domain MLANA PF14991.6 ELR20385.1 - 0.0016 18.7 0.3 0.002 18.4 0.3 1.2 1 0 0 1 1 1 1 Protein melan-A DUF2178 PF09946.9 ELR20385.1 - 0.004 17.3 0.1 0.0049 17.0 0.1 1.1 1 0 0 1 1 1 1 Predicted membrane protein (DUF2178) DUF4571 PF15137.6 ELR20385.1 - 0.023 14.3 0.2 0.025 14.2 0.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4571) Ank_2 PF12796.7 ELR20386.1 - 3.1e-10 40.5 0.5 0.013 16.1 0.0 3.3 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_3 PF13606.6 ELR20386.1 - 4.9e-09 35.7 1.1 0.011 16.2 0.0 5.5 5 0 0 5 5 5 1 Ankyrin repeat Ank_4 PF13637.6 ELR20386.1 - 5.2e-08 33.3 1.7 0.0024 18.4 0.2 4.6 3 2 2 5 5 5 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 ELR20386.1 - 4.7e-06 26.8 0.7 0.46 10.9 0.0 4.6 4 1 1 5 5 5 2 Ankyrin repeats (many copies) Ank PF00023.30 ELR20386.1 - 0.0046 17.4 0.2 0.68 10.5 0.0 3.6 3 1 0 3 3 3 1 Ankyrin repeat Helicase_C PF00271.31 ELR20387.1 - 3.2e-09 37.1 0.0 6.7e-09 36.1 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain AAA_22 PF13401.6 ELR20387.1 - 2.4e-06 27.9 0.0 5e-06 26.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 ELR20387.1 - 1.8e-05 24.5 0.0 3e-05 23.8 0.0 1.3 1 0 0 1 1 1 1 AAA domain DEAD PF00270.29 ELR20387.1 - 0.0028 17.4 0.1 0.0086 15.9 0.1 1.7 1 1 0 1 1 1 1 DEAD/DEAH box helicase AAA_19 PF13245.6 ELR20387.1 - 0.0057 17.0 0.0 0.01 16.1 0.0 1.4 1 0 0 1 1 1 1 AAA domain ABC_tran PF00005.27 ELR20387.1 - 0.012 16.1 0.1 5.9 7.4 0.0 2.3 1 1 0 2 2 2 0 ABC transporter PhoH PF02562.16 ELR20387.1 - 0.012 15.0 0.0 0.038 13.4 0.0 1.8 2 0 0 2 2 2 0 PhoH-like protein DUF2075 PF09848.9 ELR20387.1 - 0.041 13.1 0.0 0.063 12.5 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_16 PF13191.6 ELR20387.1 - 0.058 13.8 0.1 0.2 12.0 0.0 1.9 2 0 0 2 2 2 0 AAA ATPase domain Helicase_RecD PF05127.14 ELR20387.1 - 0.089 12.6 0.0 0.15 11.9 0.0 1.3 1 0 0 1 1 1 0 Helicase DNA_pol3_delta PF06144.13 ELR20387.1 - 0.11 12.2 0.0 21 4.8 0.0 2.5 3 0 0 3 3 3 0 DNA polymerase III, delta subunit AAA_24 PF13479.6 ELR20387.1 - 0.14 11.8 0.1 0.25 11.1 0.1 1.5 1 1 0 1 1 1 0 AAA domain AAA_14 PF13173.6 ELR20387.1 - 0.17 11.9 0.0 4.9 7.2 0.0 2.3 1 1 0 1 1 1 0 AAA domain NB-ARC PF00931.22 ELR20387.1 - 0.18 11.0 0.0 0.29 10.3 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain Myosin_head PF00063.21 ELR20387.1 - 0.2 9.8 0.0 0.29 9.3 0.0 1.1 1 0 0 1 1 1 0 Myosin head (motor domain) DAP3 PF10236.9 ELR20387.1 - 0.21 10.7 0.0 0.32 10.1 0.0 1.2 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 Tubulin PF00091.25 ELR20390.1 - 1.5e-20 74.2 0.0 2.1e-20 73.8 0.0 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_3 PF14881.6 ELR20390.1 - 2.8e-05 23.9 0.0 4.4e-05 23.2 0.0 1.3 1 0 0 1 1 1 1 Tubulin domain NmrA PF05368.13 ELR20392.1 - 0.038 13.5 0.0 0.07 12.7 0.0 1.5 1 0 0 1 1 1 0 NmrA-like family NAD_binding_10 PF13460.6 ELR20392.1 - 0.047 13.6 0.0 0.071 13.0 0.0 1.2 1 0 0 1 1 1 0 NAD(P)H-binding GAIN PF16489.5 ELR20393.1 - 0.12 11.8 0.2 0.26 10.7 0.2 1.5 1 0 0 1 1 1 0 GPCR-Autoproteolysis INducing (GAIN) domain Capsid_N PF16903.5 ELR20395.1 - 2.8e-47 161.0 0.0 3.3e-47 160.8 0.0 1.1 1 0 0 1 1 1 1 Major capsid protein N-terminus Ntox5 PF15543.6 ELR20395.1 - 0.047 13.5 0.0 0.084 12.7 0.0 1.4 1 0 0 1 1 1 0 Bacterial toxin 5 Sigma70_ner PF04546.13 ELR20397.1 - 0.023 14.6 0.2 0.03 14.2 0.2 1.3 1 1 0 1 1 1 0 Sigma-70, non-essential region SCIMP PF15050.6 ELR20398.1 - 0.87 10.0 3.8 20 5.6 0.1 3.0 1 1 2 3 3 3 0 SCIMP protein eIF_4EBP PF05456.11 ELR20398.1 - 2.1 8.3 13.3 4.2 7.4 1.6 2.8 1 1 1 2 2 2 0 Eukaryotic translation initiation factor 4E binding protein (EIF4EBP) PapD_C PF02753.17 ELR20398.1 - 7.1 7.1 8.1 56 4.2 0.1 3.8 3 2 2 5 5 5 0 Pili assembly chaperone PapD, C-terminal domain Lipase_3 PF01764.25 ELR20402.1 - 6e-20 71.6 0.0 8.3e-20 71.1 0.0 1.2 1 0 0 1 1 1 1 Lipase (class 3) DUF2974 PF11187.8 ELR20402.1 - 0.0023 17.5 0.0 0.0031 17.1 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2974) Hydrolase_4 PF12146.8 ELR20402.1 - 0.01 15.1 0.1 0.02 14.1 0.1 1.4 1 1 0 1 1 1 0 Serine aminopeptidase, S33 Thioesterase PF00975.20 ELR20402.1 - 0.035 14.2 0.1 0.061 13.4 0.1 1.3 1 1 0 1 1 1 0 Thioesterase domain Abhydrolase_3 PF07859.13 ELR20402.1 - 0.048 13.5 0.0 0.063 13.1 0.0 1.2 1 0 0 1 1 1 0 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 ELR20402.1 - 0.075 13.6 0.7 0.15 12.6 0.4 1.5 1 1 1 2 2 2 0 Alpha/beta hydrolase family Esterase PF00756.20 ELR20402.1 - 0.12 12.0 0.1 0.15 11.6 0.1 1.2 1 0 0 1 1 1 0 Putative esterase RVT_1 PF00078.27 ELR20403.1 - 4.2e-12 46.1 0.0 8e-12 45.1 0.0 1.5 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Glucodextran_N PF09137.11 ELR20403.1 - 0.07 12.7 0.2 0.13 11.8 0.2 1.3 1 0 0 1 1 1 0 Glucodextranase, domain N COPI_C PF06957.11 ELR20403.1 - 0.78 8.4 3.9 1.3 7.7 3.9 1.3 1 0 0 1 1 1 0 Coatomer (COPI) alpha subunit C-terminus PCNA_C PF02747.15 ELR20405.1 - 0.12 12.5 0.0 0.2 11.8 0.0 1.3 1 1 0 1 1 1 0 Proliferating cell nuclear antigen, C-terminal domain ArsA_HSP20 PF17886.1 ELR20405.1 - 0.18 11.4 0.0 0.26 10.9 0.0 1.2 1 0 0 1 1 1 0 HSP20-like domain found in ArsA Ank_4 PF13637.6 ELR20407.1 - 5.5e-26 90.6 9.9 0.013 16.0 0.0 11.4 8 2 1 9 9 9 7 Ankyrin repeats (many copies) Ank_2 PF12796.7 ELR20407.1 - 5.6e-14 52.5 0.5 0.71 10.5 0.0 7.5 1 1 9 10 10 10 8 Ankyrin repeats (3 copies) Ank_5 PF13857.6 ELR20407.1 - 2e-08 34.3 20.3 23 5.4 0.0 14.1 13 4 4 17 17 17 1 Ankyrin repeats (many copies) CXCXC PF03128.14 ELR20407.1 - 9.8e-06 25.7 34.4 0.65 10.6 0.2 11.3 12 0 0 12 12 12 3 CXCXC repeat F-box PF00646.33 ELR20407.1 - 2.3e-05 24.1 0.1 4.5e-05 23.2 0.1 1.4 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 ELR20407.1 - 0.006 16.5 0.0 0.015 15.2 0.0 1.6 1 0 0 1 1 1 1 F-box-like YoaP PF14268.6 ELR20407.1 - 0.061 12.8 0.0 6.4 6.4 0.0 4.2 4 0 0 4 4 4 0 YoaP-like PBP_like_2 PF12849.7 ELR20408.1 - 8.1e-18 65.1 0.0 1.6e-09 37.9 0.2 2.4 2 1 0 2 2 2 2 PBP superfamily domain Pkinase_Tyr PF07714.17 ELR20409.1 - 2e-84 282.9 0.0 7.6e-61 205.6 0.0 3.2 2 1 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 ELR20409.1 - 2.8e-72 243.2 0.0 4.3e-50 170.5 0.0 3.1 3 0 0 3 3 3 3 Protein kinase domain Guanylate_cyc PF00211.20 ELR20409.1 - 6.9e-09 35.6 0.0 1.2e-08 34.8 0.0 1.3 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain EGF_2 PF07974.13 ELR20409.1 - 0.0027 18.1 8.6 0.0052 17.1 8.6 1.5 1 0 0 1 1 1 1 EGF-like domain EGF PF00008.27 ELR20409.1 - 0.0076 16.5 3.9 0.014 15.7 3.9 1.4 1 0 0 1 1 1 1 EGF-like domain TAP_C PF03943.13 ELR20409.1 - 0.032 13.9 0.1 15 5.3 0.0 3.2 3 0 0 3 3 3 0 TAP C-terminal domain TMEM154 PF15102.6 ELR20409.1 - 0.035 14.0 0.0 0.07 13.0 0.0 1.4 1 0 0 1 1 1 0 TMEM154 protein family MFS_1 PF07690.16 ELR20409.1 - 0.037 13.0 0.0 0.062 12.2 0.0 1.2 1 0 0 1 1 1 0 Major Facilitator Superfamily Kinase-like PF14531.6 ELR20409.1 - 0.037 13.3 0.0 0.14 11.5 0.0 1.8 2 0 0 2 2 2 0 Kinase-like FTA2 PF13095.6 ELR20409.1 - 0.084 12.5 0.0 0.23 11.1 0.0 1.7 1 1 1 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 hEGF PF12661.7 ELR20409.1 - 0.17 12.6 3.2 0.41 11.4 3.2 1.7 1 0 0 1 1 1 0 Human growth factor-like EGF Laminin_EGF PF00053.24 ELR20409.1 - 1 9.6 5.5 1.9 8.7 5.5 1.4 1 0 0 1 1 1 0 Laminin EGF domain PDGLE PF13190.6 ELR20410.1 - 5.3 7.0 6.4 8.7 6.3 6.2 1.5 1 1 0 1 1 1 0 PDGLE domain Resolvase PF00239.21 ELR20411.1 - 3.1e-07 30.6 0.0 4.7e-07 30.0 0.0 1.3 1 0 0 1 1 1 1 Resolvase, N terminal domain HTH_17 PF12728.7 ELR20411.1 - 0.0012 19.0 0.0 0.0027 17.9 0.0 1.7 1 0 0 1 1 1 1 Helix-turn-helix domain MerR_1 PF13411.6 ELR20411.1 - 0.078 13.1 0.0 0.15 12.2 0.0 1.5 1 0 0 1 1 1 0 MerR HTH family regulatory protein DUF1441 PF07278.11 ELR20411.1 - 0.13 12.2 0.0 0.2 11.6 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1441) HTH_OrfB_IS605 PF12323.8 ELR20412.1 - 4.5e-06 26.1 0.2 9.3e-06 25.0 0.2 1.6 1 0 0 1 1 1 1 Helix-turn-helix domain OrfB_Zn_ribbon PF07282.11 ELR20413.1 - 4.1e-18 65.1 0.4 1.2e-17 63.6 0.2 1.8 2 0 0 2 2 2 1 Putative transposase DNA-binding domain OrfB_IS605 PF01385.19 ELR20413.1 - 3.1e-08 33.9 1.0 4.8e-08 33.3 0.0 1.7 2 0 0 2 2 2 1 Probable transposase C1_2 PF03107.16 ELR20413.1 - 0.03 14.6 1.0 0.062 13.6 1.0 1.5 1 0 0 1 1 1 0 C1 domain DUF883 PF05957.13 ELR20413.1 - 0.044 14.4 0.9 0.082 13.5 0.9 1.3 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF883) MAM PF00629.23 ELR20414.1 - 1.3e-08 35.0 0.1 2.4e-08 34.0 0.1 1.3 1 1 0 1 1 1 1 MAM domain, meprin/A5/mu Abhydrolase_6 PF12697.7 ELR20416.1 - 5.6e-15 56.5 2.0 7.3e-15 56.2 2.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 ELR20416.1 - 1.8e-14 54.0 0.2 4.4e-14 52.7 0.1 1.6 2 0 0 2 2 2 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 ELR20416.1 - 2e-12 46.9 0.3 1.7e-11 43.9 0.1 2.2 3 0 0 3 3 3 1 Serine aminopeptidase, S33 Esterase PF00756.20 ELR20416.1 - 0.048 13.3 0.2 0.13 11.9 0.2 1.7 1 1 0 1 1 1 0 Putative esterase DLH PF01738.18 ELR20416.1 - 0.072 12.6 0.0 2.4 7.7 0.0 2.5 2 1 0 2 2 2 0 Dienelactone hydrolase family Abhydro_lipase PF04083.16 ELR20416.1 - 0.12 12.0 0.0 0.3 10.7 0.0 1.7 1 0 0 1 1 1 0 Partial alpha/beta-hydrolase lipase region Peptidase_S15 PF02129.18 ELR20416.1 - 0.14 11.7 0.1 0.33 10.5 0.0 1.6 2 0 0 2 2 2 0 X-Pro dipeptidyl-peptidase (S15 family) DUF1583 PF07622.11 ELR20416.1 - 0.19 10.5 0.1 0.29 9.8 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1583) Pkinase PF00069.25 ELR20417.1 - 2.9e-15 56.3 0.0 2.8e-14 53.1 0.0 2.2 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR20417.1 - 1.3e-09 37.8 0.0 3.9e-09 36.2 0.0 1.8 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ELR20417.1 - 0.0009 18.6 0.0 0.019 14.3 0.0 2.2 2 0 0 2 2 2 1 Kinase-like HEAT_2 PF13646.6 ELR20417.1 - 0.081 13.3 2.3 0.11 12.9 0.5 2.2 2 0 0 2 2 2 0 HEAT repeats CAMP_factor PF07373.11 ELR20417.1 - 0.1 12.2 0.2 0.16 11.6 0.2 1.2 1 0 0 1 1 1 0 CAMP factor (Cfa) ODAPH PF15848.5 ELR20417.1 - 0.14 12.6 0.1 0.44 11.0 0.1 1.9 1 0 0 1 1 1 0 Odontogenesis associated phosphoprotein MtN3_slv PF03083.16 ELR20418.1 - 4.8e-13 49.0 3.1 8.6e-12 44.9 3.0 1.9 1 1 0 1 1 1 1 Sugar efflux transporter for intercellular exchange Alk_phosphatase PF00245.20 ELR20419.1 - 2.6e-88 296.8 0.4 3.8e-87 293.0 0.4 2.1 1 1 0 1 1 1 1 Alkaline phosphatase Metalloenzyme PF01676.18 ELR20419.1 - 1.5e-06 27.8 0.1 9.6e-06 25.1 0.1 2.0 2 0 0 2 2 2 1 Metalloenzyme superfamily Proteasome PF00227.26 ELR20420.1 - 3.3e-55 186.5 0.2 4e-55 186.3 0.2 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 ELR20420.1 - 1e-12 47.5 0.1 1.7e-12 46.8 0.1 1.4 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature Nop PF01798.18 ELR20421.1 - 3.4e-83 278.6 0.1 3.4e-83 278.6 0.1 2.1 2 0 0 2 2 2 1 snoRNA binding domain, fibrillarin NOP5NT PF08156.13 ELR20421.1 - 1.2e-21 76.8 1.7 1.2e-21 76.8 1.7 2.4 2 0 0 2 2 2 1 NOP5NT (NUC127) domain CDC27 PF09507.10 ELR20421.1 - 0.38 10.1 39.7 0.66 9.3 39.7 1.3 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Med27 PF11571.8 ELR20422.1 - 5.9e-15 55.4 0.0 1.1e-14 54.5 0.0 1.4 1 0 0 1 1 1 1 Mediator complex subunit 27 Myotub-related PF06602.14 ELR20424.1 - 1.1e-136 455.4 0.0 1.6e-136 454.9 0.0 1.1 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain FERM_f0 PF16511.5 ELR20424.1 - 2e-22 79.3 0.0 1.1e-08 35.3 0.0 3.4 3 0 0 3 3 3 3 N-terminal or F0 domain of Talin-head FERM GRAM PF02893.20 ELR20424.1 - 0.00057 19.7 0.0 0.0013 18.6 0.0 1.6 1 0 0 1 1 1 1 GRAM domain Pkinase PF00069.25 ELR20425.1 - 4.4e-75 252.4 0.0 5.5e-75 252.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR20425.1 - 9e-34 116.9 0.0 1.2e-33 116.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ELR20425.1 - 1e-08 34.9 0.0 2.5e-08 33.6 0.0 1.6 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.14 ELR20425.1 - 2.4e-06 27.1 1.2 6.9e-06 25.6 0.1 2.1 3 0 0 3 3 3 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 ELR20425.1 - 0.00011 21.9 0.1 0.00019 21.1 0.1 1.3 1 0 0 1 1 1 1 RIO1 family Pkinase_fungal PF17667.1 ELR20425.1 - 0.0018 17.1 0.0 0.0027 16.5 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Clat_adaptor_s PF01217.20 ELR20425.1 - 0.0039 17.1 0.1 0.0096 15.9 0.0 1.6 1 1 0 1 1 1 1 Clathrin adaptor complex small chain APH PF01636.23 ELR20425.1 - 0.03 14.3 0.1 0.33 10.8 0.4 2.0 1 1 1 2 2 2 0 Phosphotransferase enzyme family LIM PF00412.22 ELR20426.1 - 4.5e-25 87.6 41.1 1.9e-09 37.6 4.5 4.9 5 0 0 5 5 5 3 LIM domain DZR PF12773.7 ELR20426.1 - 0.0026 17.7 0.7 0.0026 17.7 0.7 6.0 2 1 0 2 2 2 1 Double zinc ribbon zinc_ribbon_2 PF13240.6 ELR20426.1 - 0.025 14.3 1.7 0.025 14.3 1.7 7.9 9 1 0 9 9 9 0 zinc-ribbon domain Methyltransf_11 PF08241.12 ELR20427.1 - 1e-13 51.7 0.0 2.1e-13 50.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ELR20427.1 - 2.2e-11 44.3 0.0 4.8e-11 43.2 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ELR20427.1 - 1.1e-06 28.6 0.0 1.6e-06 28.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 ELR20427.1 - 2e-06 27.7 0.0 1.5e-05 24.9 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 ELR20427.1 - 2.7e-05 24.8 0.4 7.6e-05 23.4 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_9 PF08003.11 ELR20427.1 - 0.043 12.7 0.0 1.1 8.1 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1698) Pox_Ag35 PF03286.14 ELR20427.1 - 0.45 10.3 9.2 0.64 9.8 9.2 1.2 1 0 0 1 1 1 0 Pox virus Ag35 surface protein Zip PF02535.22 ELR20427.1 - 5.8 6.0 5.6 9.3 5.4 5.6 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter NPR3 PF03666.13 ELR20427.1 - 7.1 5.3 8.3 11 4.7 8.3 1.3 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Dynactin PF12455.8 ELR20428.1 - 6.1e-31 107.7 2.1 6.1e-31 107.7 2.1 6.0 5 2 1 6 6 6 1 Dynein associated protein CAP_GLY PF01302.25 ELR20428.1 - 1e-14 54.3 0.7 1.7e-14 53.5 0.7 1.4 1 0 0 1 1 1 1 CAP-Gly domain CHB_HEX PF03173.13 ELR20429.1 - 0.031 14.0 0.2 0.055 13.2 0.1 1.5 2 0 0 2 2 2 0 Putative carbohydrate binding domain CBF PF03914.17 ELR20430.1 - 6.3e-34 117.5 9.0 4.6e-33 114.7 4.2 3.1 2 1 0 2 2 2 2 CBF/Mak21 family aGPT-Pplase3 PF18746.1 ELR20430.1 - 0.059 12.7 0.0 0.1 12.0 0.0 1.3 1 0 0 1 1 1 0 Alpha-glutamyl/putrescinyl thymine pyrophosphorylase clade 3 DHHC PF01529.20 ELR20431.1 - 2.5e-11 43.8 7.8 2.5e-11 43.8 7.8 2.3 2 1 0 2 2 2 1 DHHC palmitoyltransferase TIMELESS_C PF05029.13 ELR20432.1 - 0.026 13.7 7.1 0.032 13.4 7.1 1.1 1 0 0 1 1 1 0 Timeless protein C terminal region Cyclin_N PF00134.23 ELR20433.1 - 5.9e-09 35.8 0.3 1.3e-08 34.6 0.1 1.7 2 0 0 2 2 2 1 Cyclin, N-terminal domain Cyclin_C_2 PF16899.5 ELR20433.1 - 1.3e-05 25.6 0.9 6.6e-05 23.2 0.4 2.4 2 1 0 2 2 2 1 Cyclin C-terminal domain Cyclin_C PF02984.19 ELR20433.1 - 4e-05 23.7 0.6 0.17 11.9 0.0 3.0 2 1 1 3 3 3 2 Cyclin, C-terminal domain DUF4805 PF16063.5 ELR20434.1 - 0.17 11.2 2.5 0.27 10.5 1.6 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4805) PFK PF00365.20 ELR20434.1 - 0.19 11.0 0.0 0.32 10.3 0.0 1.3 1 0 0 1 1 1 0 Phosphofructokinase DUF572 PF04502.13 ELR20436.1 - 1.5e-77 261.4 1.5 1.7e-77 261.3 1.5 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF572) E6 PF00518.17 ELR20436.1 - 0.083 13.3 0.6 2.4 8.7 1.0 2.4 1 1 1 2 2 2 0 Early Protein (E6) zf-CSL PF05207.13 ELR20436.1 - 0.31 10.8 1.4 0.49 10.2 0.4 1.9 1 1 0 1 1 1 0 CSL zinc finger TF_Zn_Ribbon PF08271.12 ELR20436.1 - 0.98 9.0 4.9 0.32 10.6 0.2 2.6 3 0 0 3 3 3 0 TFIIB zinc-binding Rootletin PF15035.6 ELR20437.1 - 0.00035 20.6 10.6 0.00035 20.6 10.6 2.3 1 1 1 2 2 2 1 Ciliary rootlet component, centrosome cohesion Lzipper-MIP1 PF14389.6 ELR20437.1 - 0.0059 16.9 18.2 0.076 13.3 1.4 3.8 2 1 1 4 4 4 2 Leucine-zipper of ternary complex factor MIP1 DivIVA PF05103.13 ELR20437.1 - 0.0096 16.0 7.8 0.0096 16.0 7.8 2.3 2 1 0 2 2 2 1 DivIVA protein Taxilin PF09728.9 ELR20437.1 - 0.011 14.9 5.6 0.011 14.9 5.6 2.2 2 0 0 2 2 2 0 Myosin-like coiled-coil protein Filament PF00038.21 ELR20437.1 - 0.015 14.9 17.6 0.029 14.0 8.0 2.4 2 1 0 2 2 2 0 Intermediate filament protein YtxH PF12732.7 ELR20437.1 - 0.034 14.7 5.0 1.4 9.5 0.0 2.4 1 1 0 2 2 2 0 YtxH-like protein HemX PF04375.14 ELR20437.1 - 0.11 11.8 19.5 0.076 12.3 8.2 2.1 2 0 0 2 2 2 0 HemX, putative uroporphyrinogen-III C-methyltransferase LMBR1 PF04791.16 ELR20437.1 - 0.15 10.9 3.7 0.2 10.6 3.7 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein TMPIT PF07851.13 ELR20437.1 - 0.46 9.7 12.8 1.8 7.7 4.5 2.1 2 0 0 2 2 2 0 TMPIT-like protein ZYG-11_interact PF05884.12 ELR20437.1 - 0.61 9.5 2.0 1.5 8.1 2.0 1.8 1 1 0 1 1 1 0 Interactor of ZYG-11 Atg14 PF10186.9 ELR20437.1 - 1.3 8.0 11.3 1.3 8.0 10.1 1.5 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF3450 PF11932.8 ELR20437.1 - 1.4 8.1 15.2 0.26 10.5 5.7 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF3450) FapA PF03961.13 ELR20437.1 - 1.9 7.0 13.8 0.73 8.4 2.1 2.1 1 1 0 2 2 2 0 Flagellar Assembly Protein A Jnk-SapK_ap_N PF09744.9 ELR20437.1 - 2.9 8.1 23.4 0.64 10.2 9.0 2.3 2 0 0 2 2 2 0 JNK_SAPK-associated protein-1 RB_A PF01858.17 ELR20437.1 - 3.2 7.5 5.8 1.2 8.9 0.4 2.5 3 0 0 3 3 3 0 Retinoblastoma-associated protein A domain T2SSF PF00482.23 ELR20437.1 - 6.2 6.8 10.0 2.8 7.9 2.6 2.9 1 1 1 2 2 2 0 Type II secretion system (T2SS), protein F DMPK_coil PF08826.10 ELR20437.1 - 8 6.6 19.8 0.38 10.9 2.9 4.1 4 1 0 4 4 4 0 DMPK coiled coil domain like APG6_N PF17675.1 ELR20437.1 - 9.8 6.7 26.7 14 6.2 19.0 2.5 1 1 1 2 2 2 0 Apg6 coiled-coil region F-box-like PF12937.7 ELR20438.1 - 2.8e-07 30.3 0.8 7.4e-07 29.0 0.8 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ELR20438.1 - 0.0045 16.8 0.4 0.0085 16.0 0.4 1.4 1 0 0 1 1 1 1 F-box domain Ras PF00071.22 ELR20438.1 - 0.0045 16.6 0.0 2.8 7.5 0.0 2.3 2 0 0 2 2 2 2 Ras family HSBP1 PF06825.12 ELR20438.1 - 0.15 11.9 0.1 1.7 8.5 0.2 2.4 2 0 0 2 2 2 0 Heat shock factor binding protein 1 BBP1_C PF15272.6 ELR20438.1 - 2.3 8.0 15.7 1.3 8.8 3.0 3.5 2 1 1 3 3 3 0 Spindle pole body component BBP1, C-terminal DDE_Tnp_1_6 PF13751.6 ELR20438.1 - 4.5 7.5 8.3 3.1 8.0 2.7 3.0 1 1 1 2 2 2 0 Transposase DDE domain Chalcone_2 PF16035.5 ELR20440.1 - 1.9e-20 73.5 0.1 6.2e-19 68.6 0.1 2.0 1 1 0 1 1 1 1 Chalcone isomerase like Chalcone_3 PF16036.5 ELR20440.1 - 2.7e-12 47.1 0.1 1.1e-10 41.8 0.1 2.1 1 1 0 1 1 1 1 Chalcone isomerase-like Chalcone PF02431.15 ELR20440.1 - 5.8e-07 29.1 0.0 9e-07 28.5 0.0 1.3 1 0 0 1 1 1 1 Chalcone-flavanone isomerase RNB PF00773.19 ELR20441.1 - 1.6e-102 343.2 0.0 2.1e-102 342.8 0.0 1.2 1 0 0 1 1 1 1 RNB domain OB_Dis3 PF17849.1 ELR20441.1 - 3.8e-21 74.9 0.0 7.9e-21 73.9 0.0 1.6 1 0 0 1 1 1 1 Dis3-like cold-shock domain 2 (CSD2) Rrp44_CSD1 PF17216.3 ELR20441.1 - 9.2e-10 38.4 2.0 1.1e-09 38.1 0.2 2.0 2 0 0 2 2 2 1 Rrp44-like cold shock domain R3H PF01424.22 ELR20441.1 - 3.6e-09 36.5 0.5 8.9e-09 35.2 0.1 2.0 2 0 0 2 2 2 1 R3H domain Dis3l2_C_term PF17877.1 ELR20441.1 - 1.3e-08 35.1 0.0 3.9e-08 33.5 0.0 1.8 1 0 0 1 1 1 1 DIS3-like exonuclease 2 C terminal zf-CCHC PF00098.23 ELR20441.1 - 2.1e-06 27.5 1.2 5.7e-06 26.2 1.2 1.8 1 0 0 1 1 1 1 Zinc knuckle CSD2 PF17876.1 ELR20441.1 - 6.4e-05 23.0 0.1 0.0019 18.3 0.0 3.1 3 0 0 3 3 3 1 Cold shock domain CBS PF00571.28 ELR20442.1 - 1.5e-30 105.4 7.0 1.8e-15 57.1 0.9 2.5 3 0 0 3 3 3 2 CBS domain Glyco_hydro_3 PF00933.21 ELR20442.1 - 0.0098 15.3 0.1 0.012 15.0 0.1 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Nup35_RRM_2 PF14605.6 ELR20442.1 - 0.019 15.0 0.0 0.031 14.3 0.0 1.4 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif DUF383 PF04063.14 ELR20443.1 - 3.9e-37 127.8 0.1 8.6e-37 126.7 0.1 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF383) DUF384 PF04064.13 ELR20443.1 - 8.3e-17 60.8 0.1 5.5e-16 58.2 0.0 2.4 2 0 0 2 2 2 1 Domain of unknown function (DUF384) MutL_C PF08676.11 ELR20444.1 - 5.3e-11 42.5 0.1 2.9e-07 30.3 0.1 2.4 1 1 1 2 2 2 2 MutL C terminal dimerisation domain DNA_mis_repair PF01119.19 ELR20444.1 - 5.3e-07 29.3 0.0 0.0036 17.0 0.0 2.5 2 0 0 2 2 2 2 DNA mismatch repair protein, C-terminal domain PARG_cat PF05028.14 ELR20445.1 - 0.11 11.7 0.0 0.14 11.4 0.0 1.1 1 0 0 1 1 1 0 Poly (ADP-ribose) glycohydrolase (PARG) RasGAP PF00616.19 ELR20446.1 - 2.8e-22 79.5 0.0 5.4e-22 78.5 0.0 1.5 1 0 0 1 1 1 1 GTPase-activator protein for Ras-like GTPase Laminin_G_3 PF13385.6 ELR20446.1 - 3.2e-13 50.1 0.1 1.2e-12 48.2 0.0 2.1 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Ig_3 PF13927.6 ELR20446.1 - 0.0075 16.8 0.1 0.031 14.9 0.1 2.1 1 0 0 1 1 1 1 Immunoglobulin domain DUF4381 PF14316.6 ELR20447.1 - 0.44 10.8 3.4 0.65 10.2 0.4 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4381) HSP90 PF00183.18 ELR20448.1 - 2.7e-175 584.2 11.2 2.7e-173 577.6 11.2 2.0 1 1 0 1 1 1 1 Hsp90 protein TINF2_N PF14973.6 ELR20448.1 - 0.028 14.8 4.1 1 9.7 0.5 2.4 2 0 0 2 2 2 0 TERF1-interacting nuclear factor 2 N-terminus LOH1CR12 PF10158.9 ELR20448.1 - 0.13 12.3 0.5 0.32 11.0 0.1 1.8 2 0 0 2 2 2 0 Tumour suppressor protein WD40 PF00400.32 ELR20449.1 - 1.9e-06 28.5 7.3 0.0061 17.4 0.2 4.0 4 1 0 4 4 4 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ELR20449.1 - 0.00063 20.0 0.5 1.6 9.1 0.2 3.8 2 1 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain AGOG PF09171.10 ELR20449.1 - 0.067 12.5 0.2 0.11 11.9 0.2 1.2 1 0 0 1 1 1 0 N-glycosylase/DNA lyase DUF179 PF02622.15 ELR20450.1 - 2.4e-10 40.6 0.1 3.7e-09 36.7 0.0 2.0 2 0 0 2 2 2 1 Uncharacterized ACR, COG1678 ANAPC15 PF15243.6 ELR20450.1 - 0.048 14.1 7.8 0.16 12.4 0.0 2.3 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 15 HSP90 PF00183.18 ELR20453.1 - 1.4e-235 783.1 31.8 2.2e-235 782.5 31.8 1.2 1 0 0 1 1 1 1 Hsp90 protein HATPase_c PF02518.26 ELR20453.1 - 1.6e-14 54.3 0.0 3.3e-14 53.3 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 ELR20453.1 - 9.8e-10 38.4 0.0 9.8e-10 38.4 0.0 2.1 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Coilin_N PF15862.5 ELR20453.1 - 0.00071 19.4 3.1 9.8 6.0 11.7 2.9 2 1 0 2 2 2 1 Coilin N-terminus DUF2849 PF11011.8 ELR20453.1 - 4.1 8.1 6.8 36 5.1 0.0 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2849) DUF2052 PF09747.9 ELR20453.1 - 4.8 7.3 20.9 2.3 8.3 15.0 2.4 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) PTPRCAP PF15713.5 ELR20453.1 - 5.3 7.3 17.9 0.44 10.8 11.8 2.2 2 0 0 2 2 2 0 Protein tyrosine phosphatase receptor type C-associated Merozoite_SPAM PF07133.11 ELR20453.1 - 8.3 6.4 39.3 1.4 8.9 25.8 3.4 3 0 0 3 3 3 0 Merozoite surface protein (SPAM) WD40 PF00400.32 ELR20454.1 - 8.2e-07 29.6 4.1 0.011 16.5 0.2 4.0 4 0 0 4 4 4 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ELR20454.1 - 0.0031 17.8 0.3 3.4 8.0 0.1 3.7 1 1 3 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain AGOG PF09171.10 ELR20454.1 - 0.025 13.9 0.3 0.047 13.0 0.3 1.3 1 0 0 1 1 1 0 N-glycosylase/DNA lyase DUF4079 PF13301.6 ELR20455.1 - 0.0015 18.7 0.3 0.0015 18.7 0.3 2.1 2 1 0 2 2 2 1 Protein of unknown function (DUF4079) RMI2 PF16100.5 ELR20456.1 - 1.6e-17 63.5 0.0 2.4e-17 63.0 0.0 1.3 1 0 0 1 1 1 1 RecQ-mediated genome instability protein 2 Pkinase PF00069.25 ELR20457.1 - 1.2e-30 106.8 0.0 1.2e-29 103.6 0.0 2.4 1 1 0 1 1 1 1 Protein kinase domain DSPc PF00782.20 ELR20457.1 - 6.3e-25 87.5 0.0 1.5e-24 86.3 0.0 1.7 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Pkinase_Tyr PF07714.17 ELR20457.1 - 3.8e-18 65.7 0.0 8.1e-14 51.5 0.0 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase ABC1 PF03109.16 ELR20457.1 - 0.075 13.2 0.0 0.28 11.4 0.0 1.9 1 0 0 1 1 1 0 ABC1 family DUF4028 PF13220.6 ELR20458.1 - 0.0043 16.8 0.0 0.012 15.3 0.0 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF4028) Alginate_exp PF13372.6 ELR20458.1 - 0.1 11.3 0.0 0.14 10.9 0.0 1.3 1 0 0 1 1 1 0 Alginate export DUF1571 PF07608.11 ELR20458.1 - 0.12 11.8 0.0 0.21 11.0 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1571) Ank_5 PF13857.6 ELR20459.1 - 1.8e-18 66.4 0.3 3.2e-09 36.9 0.0 2.6 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 ELR20459.1 - 1.2e-15 57.9 0.2 2.3e-15 56.9 0.2 1.5 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 ELR20459.1 - 2.5e-14 51.9 0.9 4.8e-05 23.4 0.0 3.7 3 0 0 3 3 3 2 Ankyrin repeat zf-C3HC4_3 PF13920.6 ELR20459.1 - 1.1e-12 47.6 13.3 2.3e-12 46.6 13.3 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Ank_4 PF13637.6 ELR20459.1 - 2e-12 47.3 0.2 2.9e-10 40.5 0.1 3.2 3 1 1 4 4 4 2 Ankyrin repeats (many copies) Ank PF00023.30 ELR20459.1 - 1.9e-11 43.8 1.7 2.5e-05 24.5 0.1 3.7 3 0 0 3 3 3 2 Ankyrin repeat zf-RING_5 PF14634.6 ELR20459.1 - 0.012 15.5 14.3 0.028 14.4 14.3 1.6 1 0 0 1 1 1 0 zinc-RING finger domain Prok-RING_4 PF14447.6 ELR20459.1 - 0.018 14.9 14.7 0.018 14.9 14.7 1.7 2 0 0 2 2 2 0 Prokaryotic RING finger family 4 zf-C3HC4 PF00097.25 ELR20459.1 - 0.75 9.7 17.7 0.59 10.1 13.0 2.7 2 1 1 3 3 3 0 Zinc finger, C3HC4 type (RING finger) His_Phos_2 PF00328.22 ELR20460.1 - 7.9e-25 88.0 0.0 1e-24 87.6 0.0 1.1 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) Kinase-PolyVal PF18762.1 ELR20460.1 - 0.048 13.6 0.0 0.096 12.6 0.0 1.4 1 0 0 1 1 1 0 Serine/Threonine/Tyrosine Kinase found in polyvalent proteins Sdh_cyt PF01127.22 ELR20461.1 - 1.1e-20 73.8 0.5 1.5e-20 73.4 0.5 1.2 1 0 0 1 1 1 1 Succinate dehydrogenase/Fumarate reductase transmembrane subunit PCNA_C PF02747.15 ELR20462.1 - 9.2e-12 45.3 0.0 4.1e-09 36.7 0.0 2.2 2 0 0 2 2 2 2 Proliferating cell nuclear antigen, C-terminal domain PCNA_N PF00705.18 ELR20462.1 - 0.061 13.0 0.3 0.89 9.3 0.1 2.2 1 1 1 2 2 2 0 Proliferating cell nuclear antigen, N-terminal domain Knl1_RWD_C PF18210.1 ELR20462.1 - 0.12 12.9 0.0 0.25 11.9 0.0 1.5 1 0 0 1 1 1 0 Knl1 RWD C-terminal domain Pkinase PF00069.25 ELR20463.1 - 3e-60 203.8 0.2 4.2e-35 121.4 0.0 2.2 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ELR20463.1 - 9.8e-24 84.0 0.1 4.3e-11 42.6 0.0 3.0 1 1 1 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 ELR20463.1 - 0.00025 20.5 0.2 0.042 13.2 0.0 2.9 2 1 0 2 2 2 1 Kinase-like DDHD PF02862.17 ELR20463.1 - 5 7.2 7.9 7.5 6.6 3.1 2.3 2 0 0 2 2 2 0 DDHD domain Hydrolase_4 PF12146.8 ELR20464.1 - 1.9e-06 27.3 0.1 5.9e-05 22.4 0.1 2.1 1 1 1 2 2 2 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 ELR20464.1 - 0.0008 19.1 0.0 0.0041 16.8 0.0 2.1 2 0 0 2 2 2 1 alpha/beta hydrolase fold BAAT_C PF08840.11 ELR20464.1 - 0.00084 19.3 0.0 0.0014 18.6 0.0 1.4 1 1 0 1 1 1 1 BAAT / Acyl-CoA thioester hydrolase C terminal Peptidase_S9 PF00326.21 ELR20464.1 - 0.0029 17.1 0.0 0.0079 15.7 0.0 1.6 2 0 0 2 2 2 1 Prolyl oligopeptidase family AXE1 PF05448.12 ELR20464.1 - 0.032 12.9 0.0 0.15 10.7 0.0 1.8 1 1 1 2 2 2 0 Acetyl xylan esterase (AXE1) FSH1 PF03959.13 ELR20464.1 - 0.051 13.2 0.1 0.69 9.5 0.1 2.2 1 1 0 1 1 1 0 Serine hydrolase (FSH1) DLH PF01738.18 ELR20464.1 - 0.062 12.9 0.0 0.97 8.9 0.0 2.2 2 0 0 2 2 2 0 Dienelactone hydrolase family Peptidase_S15 PF02129.18 ELR20464.1 - 0.2 11.2 0.1 1.1 8.7 0.1 2.0 2 0 0 2 2 2 0 X-Pro dipeptidyl-peptidase (S15 family) UIM PF02809.20 ELR20464.1 - 0.33 11.0 4.5 1.1 9.3 4.5 1.9 1 0 0 1 1 1 0 Ubiquitin interaction motif MORN PF02493.20 ELR20465.1 - 1.1e-16 59.6 23.8 6.7e-06 25.7 0.7 4.6 4 0 0 4 4 4 4 MORN repeat Ank_2 PF12796.7 ELR20466.1 - 1.5e-23 83.1 0.0 8.9e-16 58.3 0.0 3.2 3 1 0 3 3 3 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ELR20466.1 - 1.6e-20 73.2 0.3 7.6e-06 26.4 0.0 3.7 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 ELR20466.1 - 1.7e-19 69.6 2.2 2.2e-11 43.7 0.2 4.3 2 2 2 4 4 4 3 Ankyrin repeats (many copies) Ank PF00023.30 ELR20466.1 - 5.6e-18 64.5 2.4 5.7e-08 32.9 0.1 4.6 4 0 0 4 4 4 3 Ankyrin repeat Ank_3 PF13606.6 ELR20466.1 - 6.6e-16 56.8 2.0 0.002 18.5 0.0 5.5 4 1 0 4 4 4 3 Ankyrin repeat F-box-like PF12937.7 ELR20466.1 - 5e-08 32.7 0.7 9.2e-08 31.9 0.7 1.4 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ELR20466.1 - 0.0084 16.0 0.4 0.023 14.6 0.4 1.7 1 1 0 1 1 1 1 F-box domain F-box_5 PF18511.1 ELR20466.1 - 0.034 13.7 0.2 0.071 12.7 0.2 1.5 1 0 0 1 1 1 0 F-box Ras PF00071.22 ELR20467.1 - 2.7e-47 160.4 0.0 3.3e-47 160.1 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR20467.1 - 3.2e-26 91.9 0.0 5.2e-26 91.2 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR20467.1 - 1e-17 64.1 0.0 1.3e-17 63.8 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 ELR20467.1 - 5.1e-05 23.2 0.0 0.07 13.0 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase SRPRB PF09439.10 ELR20467.1 - 8.9e-05 22.0 0.0 0.00013 21.4 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 ELR20467.1 - 0.00018 21.5 0.0 0.00027 21.0 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase cobW PF02492.19 ELR20467.1 - 0.21 11.2 0.2 17 5.0 0.0 2.2 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Gtr1_RagA PF04670.12 ELR20467.1 - 0.21 10.9 0.0 0.28 10.5 0.0 1.2 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region Ras PF00071.22 ELR20468.1 - 1.2e-23 83.5 0.0 1.1e-22 80.4 0.0 1.9 1 1 0 1 1 1 1 Ras family Roc PF08477.13 ELR20468.1 - 2.8e-08 34.0 0.0 0.00098 19.3 0.0 2.2 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR20468.1 - 1.4e-06 27.8 0.0 2.3e-05 23.9 0.0 2.0 1 1 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 ELR20468.1 - 0.0015 18.5 0.0 0.099 12.5 0.0 2.1 2 0 0 2 2 2 1 RsgA GTPase MMR_HSR1 PF01926.23 ELR20468.1 - 0.0032 17.5 0.0 0.005 16.9 0.0 1.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase YccF PF03733.13 ELR20469.1 - 2e-20 73.3 22.4 3.3e-10 40.5 6.9 2.2 2 0 0 2 2 2 2 Inner membrane component domain Promethin PF16015.5 ELR20469.1 - 3.1e-05 23.8 9.7 3.4e-05 23.7 0.9 2.2 2 0 0 2 2 2 2 Promethin DUF1286 PF06939.11 ELR20469.1 - 0.0071 16.6 0.2 0.83 9.9 0.0 2.2 2 0 0 2 2 2 2 Protein of unknown function (DUF1286) Cellulase PF00150.18 ELR20470.1 - 1.6e-24 86.8 0.0 1.9e-24 86.6 0.0 1.0 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) Cellulase PF00150.18 ELR20471.1 - 1.4e-06 28.0 0.1 1.6e-06 27.7 0.1 1.1 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) Peptidase_C1 PF00112.23 ELR20475.1 - 9.5e-72 241.6 4.2 1.2e-71 241.3 4.2 1.1 1 0 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.12 ELR20475.1 - 9.7e-14 51.6 3.0 1.7e-13 50.8 3.0 1.4 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Peptidase_C1_2 PF03051.15 ELR20475.1 - 0.00017 20.5 0.3 0.015 14.1 0.1 2.1 2 0 0 2 2 2 2 Peptidase C1-like family PP2C PF00481.21 ELR20476.1 - 1.9e-47 162.1 0.0 2e-39 135.8 0.0 2.7 1 1 1 2 2 2 2 Protein phosphatase 2C Connexin PF00029.19 ELR20476.1 - 0.011 15.5 1.3 0.017 14.9 1.3 1.2 1 0 0 1 1 1 0 Connexin Auts2 PF15336.6 ELR20476.1 - 0.019 15.1 3.1 0.054 13.6 3.1 1.7 1 0 0 1 1 1 0 Autism susceptibility gene 2 protein Zip PF02535.22 ELR20476.1 - 0.02 14.1 2.2 0.038 13.2 2.2 1.4 1 0 0 1 1 1 0 ZIP Zinc transporter DUF2052 PF09747.9 ELR20476.1 - 0.02 15.0 11.5 0.041 14.0 11.5 1.5 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) SDA1 PF05285.12 ELR20476.1 - 0.047 13.1 14.9 0.093 12.1 14.9 1.4 1 0 0 1 1 1 0 SDA1 Nop14 PF04147.12 ELR20476.1 - 0.075 11.2 11.6 0.12 10.6 11.6 1.2 1 0 0 1 1 1 0 Nop14-like family SpoIIP PF07454.11 ELR20476.1 - 0.1 12.0 7.0 0.17 11.3 7.0 1.3 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) EIIBC-GUT_N PF03612.14 ELR20476.1 - 0.12 12.1 1.5 0.18 11.5 1.5 1.3 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus TCP PF03634.13 ELR20476.1 - 0.43 11.1 8.9 2.3 8.7 3.6 2.3 2 0 0 2 2 2 0 TCP family transcription factor Vfa1 PF08432.10 ELR20476.1 - 0.44 10.8 14.6 0.8 10.0 14.6 1.4 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Nha1_C PF08619.10 ELR20476.1 - 0.47 9.6 20.6 0.47 9.6 2.8 2.1 2 0 0 2 2 2 0 Alkali metal cation/H+ antiporter Nha1 C terminus TRAP_alpha PF03896.16 ELR20476.1 - 0.59 9.3 7.5 0.94 8.6 7.5 1.3 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit RR_TM4-6 PF06459.12 ELR20476.1 - 0.61 9.9 12.4 1 9.1 12.4 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Pox_Ag35 PF03286.14 ELR20476.1 - 0.63 9.8 12.3 1.3 8.8 12.3 1.4 1 0 0 1 1 1 0 Pox virus Ag35 surface protein DUF4820 PF16091.5 ELR20476.1 - 0.66 9.3 4.9 1.5 8.2 4.9 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) BUD22 PF09073.10 ELR20476.1 - 0.67 9.2 22.1 0.038 13.3 11.0 2.2 2 0 0 2 2 2 0 BUD22 Afi1 PF07792.12 ELR20476.1 - 0.78 10.2 6.3 1.8 9.1 6.3 1.6 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking DNA_pol_phi PF04931.13 ELR20476.1 - 0.88 7.6 15.0 1.3 7.1 15.0 1.2 1 0 0 1 1 1 0 DNA polymerase phi DUF4637 PF15470.6 ELR20476.1 - 1.1 9.0 13.0 3.5 7.3 13.0 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) DUF3408 PF11888.8 ELR20476.1 - 1.4 9.1 12.6 17 5.6 12.6 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3408) CPSF100_C PF13299.6 ELR20476.1 - 1.6 8.9 9.1 0.52 10.5 6.2 1.6 2 0 0 2 2 1 0 Cleavage and polyadenylation factor 2 C-terminal RPA43_OB PF17875.1 ELR20476.1 - 1.8 9.2 5.6 5.1 7.7 5.6 1.8 1 0 0 1 1 1 0 RPA43 OB domain in RNA Pol I RNA_pol_Rpc4 PF05132.14 ELR20476.1 - 1.9 8.9 15.3 0.071 13.5 7.4 2.3 3 0 0 3 3 2 0 RNA polymerase III RPC4 DUF4228 PF14009.6 ELR20476.1 - 1.9 8.8 7.9 0.62 10.4 0.8 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4228) RRN3 PF05327.11 ELR20476.1 - 2.3 6.7 9.6 3.5 6.0 9.6 1.2 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Paf1 PF03985.13 ELR20476.1 - 2.8 6.9 20.2 4.8 6.1 20.2 1.3 1 0 0 1 1 1 0 Paf1 DUF719 PF05334.13 ELR20476.1 - 2.9 8.1 9.5 0.88 9.7 5.9 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF719) RPN2_C PF18004.1 ELR20476.1 - 5.4 6.9 17.7 10 6.0 17.7 1.4 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain V_ATPase_I PF01496.19 ELR20476.1 - 5.6 4.8 6.9 8 4.2 6.9 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family CDC45 PF02724.14 ELR20476.1 - 5.7 5.1 17.5 6.4 4.9 14.1 2.0 2 0 0 2 2 2 0 CDC45-like protein DUF3464 PF11947.8 ELR20476.1 - 6.8 6.4 9.5 14 5.4 9.5 1.5 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 NPR3 PF03666.13 ELR20476.1 - 7 5.3 8.2 12 4.6 8.2 1.3 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 RNA_polI_A34 PF08208.11 ELR20476.1 - 7.8 6.5 20.6 18 5.4 20.6 1.5 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 DUF913 PF06025.12 ELR20476.1 - 8.2 5.3 9.0 0.55 9.2 3.8 1.6 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) Eapp_C PF10238.9 ELR20476.1 - 9 6.4 9.6 18 5.4 9.6 1.4 1 0 0 1 1 1 0 E2F-associated phosphoprotein NARP1 PF12569.8 ELR20476.1 - 9.3 5.0 13.4 16 4.3 13.4 1.3 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 DUF3391 PF11871.8 ELR20476.1 - 9.6 6.7 11.4 1.4 9.4 4.7 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF3391) Pkinase PF00069.25 ELR20477.1 - 1.7e-60 204.6 0.0 2.5e-60 204.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR20477.1 - 1.9e-44 151.9 0.1 4.2e-44 150.8 0.0 1.5 2 0 0 2 2 2 1 Protein tyrosine kinase Haspin_kinase PF12330.8 ELR20477.1 - 0.00042 19.4 0.4 0.0055 15.7 0.4 2.1 1 1 0 1 1 1 1 Haspin like kinase domain Pkinase_fungal PF17667.1 ELR20477.1 - 0.0036 16.1 0.0 0.0056 15.5 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 ELR20477.1 - 0.01 15.2 0.0 0.027 13.8 0.0 1.7 1 1 1 2 2 2 0 Kinase-like RhoGEF PF00621.20 ELR20480.1 - 3.1e-11 43.8 0.5 3.3e-11 43.7 0.5 1.0 1 0 0 1 1 1 1 RhoGEF domain zf-RING_2 PF13639.6 ELR20481.1 - 0.00027 21.2 14.5 0.00044 20.5 4.7 7.9 7 3 1 8 8 8 2 Ring finger domain zf-RING_11 PF17123.5 ELR20481.1 - 0.0014 18.3 3.0 0.0014 18.3 3.0 4.5 4 0 0 4 4 4 2 RING-like zinc finger Glyoxalase PF00903.25 ELR20482.1 - 7.2e-10 39.1 0.0 1.9e-09 37.8 0.0 1.7 1 1 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_2 PF12681.7 ELR20482.1 - 5.3e-05 23.1 0.0 0.00018 21.4 0.0 1.7 2 0 0 2 2 2 1 Glyoxalase-like domain Glyoxalase_4 PF13669.6 ELR20482.1 - 0.0034 17.6 0.0 0.018 15.3 0.0 2.0 1 1 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_6 PF18029.1 ELR20482.1 - 0.0047 17.7 0.0 0.0087 16.8 0.0 1.5 1 0 0 1 1 1 1 Glyoxalase-like domain tRNA-Thr_ED PF08915.11 ELR20482.1 - 0.19 11.8 0.0 0.28 11.3 0.0 1.3 1 0 0 1 1 1 0 Archaea-specific editing domain of threonyl-tRNA synthetase PRKCSH-like PF12999.7 ELR20483.1 - 4.4e-38 130.8 8.7 4.4e-38 130.8 8.7 2.3 2 0 0 2 2 2 1 Glucosidase II beta subunit-like Ldl_recept_a PF00057.18 ELR20483.1 - 0.034 14.4 3.3 0.034 14.4 3.3 3.2 2 2 1 3 3 2 0 Low-density lipoprotein receptor domain class A BUD22 PF09073.10 ELR20483.1 - 0.18 11.1 25.2 0.24 10.7 25.2 1.2 1 0 0 1 1 1 0 BUD22 Snapin_Pallidin PF14712.6 ELR20483.1 - 0.23 11.9 11.5 3.5 8.1 0.0 3.0 3 0 0 3 3 3 0 Snapin/Pallidin Hydantoinase_B PF02538.14 ELR20483.1 - 0.24 9.8 0.8 0.36 9.2 0.8 1.2 1 0 0 1 1 1 0 Hydantoinase B/oxoprolinase SlyX PF04102.12 ELR20483.1 - 2.3 8.9 15.6 0.23 12.1 5.6 3.3 3 0 0 3 3 3 0 SlyX Presenilin PF01080.17 ELR20483.1 - 2.4 6.8 8.6 3.6 6.2 8.6 1.4 1 0 0 1 1 1 0 Presenilin LMBR1 PF04791.16 ELR20483.1 - 3.2 6.6 5.7 4.7 6.0 5.7 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein DUF1664 PF07889.12 ELR20483.1 - 3.6 7.6 10.8 6.1 6.9 0.9 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF1664) Atg14 PF10186.9 ELR20483.1 - 3.9 6.5 16.4 2.3e+02 0.6 16.4 2.2 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 ALMT PF11744.8 ELR20483.1 - 6.7 5.4 8.4 9.1 5.0 8.4 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter RP-C_C PF11800.8 ELR20483.1 - 6.9 6.7 17.2 24 4.9 0.1 2.2 2 0 0 2 2 2 0 Replication protein C C-terminal region RR_TM4-6 PF06459.12 ELR20483.1 - 8 6.2 22.7 12 5.7 22.7 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 AMP-binding PF00501.28 ELR20484.1 - 4.8e-63 213.2 0.0 6.1e-63 212.9 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme CH PF00307.31 ELR20484.1 - 5.2e-34 116.7 0.0 5.4e-17 62.0 0.0 2.4 2 0 0 2 2 2 2 Calponin homology (CH) domain CAMSAP_CH PF11971.8 ELR20484.1 - 0.0034 17.2 0.0 0.34 10.8 0.0 2.4 2 0 0 2 2 2 2 CAMSAP CH domain F-box-like PF12937.7 ELR20485.1 - 3.9e-10 39.5 0.1 7.9e-10 38.5 0.1 1.6 1 1 0 1 1 1 1 F-box-like F-box PF00646.33 ELR20485.1 - 2.9e-07 30.2 0.0 4.9e-07 29.5 0.0 1.3 1 0 0 1 1 1 1 F-box domain ParBc_2 PF08857.11 ELR20486.1 - 6.5e-47 159.7 0.0 1.3e-46 158.7 0.0 1.5 1 0 0 1 1 1 1 Putative ParB-like nuclease Dicty_REP PF05086.12 ELR20486.1 - 8.4 4.2 8.2 26 2.6 8.2 1.8 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Methyltransf_23 PF13489.6 ELR20487.1 - 4.1e-06 26.7 0.0 5.4e-06 26.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ELR20487.1 - 0.00012 22.8 0.0 0.00022 21.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ELR20487.1 - 0.00085 20.0 0.0 0.043 14.5 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ELR20487.1 - 0.0011 18.8 0.0 0.0019 18.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ELR20487.1 - 0.0023 18.6 0.0 0.08 13.6 0.0 2.4 1 1 0 1 1 1 1 Methyltransferase domain T2SSM PF04612.12 ELR20487.1 - 0.17 11.9 0.1 0.26 11.3 0.1 1.2 1 0 0 1 1 1 0 Type II secretion system (T2SS), protein M ELFV_dehydrog PF00208.21 ELR20488.1 - 4.2e-54 183.9 0.0 6.9e-54 183.1 0.0 1.4 1 0 0 1 1 1 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase Bac_GDH PF05088.12 ELR20488.1 - 1.8e-29 102.1 1.2 2.3e-22 78.5 1.0 2.1 2 0 0 2 2 2 2 Bacterial NAD-glutamate dehydrogenase ELFV_dehydrog_N PF02812.18 ELR20488.1 - 0.15 11.9 0.0 0.65 9.9 0.0 2.0 2 0 0 2 2 2 0 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain PBP_like_2 PF12849.7 ELR20490.1 - 3.5e-12 46.6 0.1 4.6e-12 46.2 0.1 1.1 1 0 0 1 1 1 1 PBP superfamily domain Exo_endo_phos PF03372.23 ELR20491.1 - 1.1e-05 25.1 0.2 1.8e-05 24.4 0.2 1.3 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.6 ELR20491.1 - 0.0044 16.8 0.0 0.0073 16.1 0.0 1.4 1 1 0 1 1 1 1 Endonuclease-reverse transcriptase CsbD PF05532.12 ELR20492.1 - 1.5e-05 24.8 0.8 1.5e-05 24.8 0.8 2.1 2 0 0 2 2 2 1 CsbD-like YL1 PF05764.13 ELR20493.1 - 0.49 10.5 13.9 0.74 9.9 13.9 1.2 1 0 0 1 1 1 0 YL1 nuclear protein WBS_methylT PF12589.8 ELR20494.1 - 1.5e-21 77.0 6.6 2.7e-21 76.1 6.6 1.4 1 0 0 1 1 1 1 Methyltransferase involved in Williams-Beuren syndrome Methyltransf_11 PF08241.12 ELR20494.1 - 3.9e-14 53.1 0.0 2.6e-13 50.4 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 ELR20494.1 - 1.7e-13 51.0 0.0 6.8e-13 49.2 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 ELR20494.1 - 4.6e-08 33.0 0.0 7.3e-08 32.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ELR20494.1 - 8.7e-08 32.8 0.0 2.3e-07 31.5 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 ELR20494.1 - 2.3e-07 30.8 0.0 6.1e-07 29.4 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain CMAS PF02353.20 ELR20494.1 - 0.0043 16.4 0.0 0.0087 15.4 0.0 1.4 1 1 0 1 1 1 1 Mycolic acid cyclopropane synthetase Ubie_methyltran PF01209.18 ELR20494.1 - 0.0054 16.1 0.0 0.0079 15.6 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family MetW PF07021.12 ELR20494.1 - 0.01 15.5 0.0 0.018 14.7 0.0 1.3 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW Methyltransf_32 PF13679.6 ELR20494.1 - 0.038 14.0 0.0 0.18 11.8 0.0 1.9 2 0 0 2 2 2 0 Methyltransferase domain PCMT PF01135.19 ELR20494.1 - 0.044 13.5 0.0 0.063 13.0 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) N6_N4_Mtase PF01555.18 ELR20494.1 - 0.044 13.5 0.8 0.17 11.5 0.0 2.2 2 1 0 2 2 2 0 DNA methylase MFS_1 PF07690.16 ELR20495.1 - 2.1e-12 46.6 10.1 2.7e-12 46.3 10.1 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily LacY_symp PF01306.19 ELR20495.1 - 2.8e-05 23.1 1.9 3.1e-05 22.9 1.9 1.1 1 0 0 1 1 1 1 LacY proton/sugar symporter MFS_5 PF05631.14 ELR20495.1 - 3.4e-05 22.9 0.2 3.8e-05 22.8 0.2 1.1 1 0 0 1 1 1 1 Sugar-tranasporters, 12 TM Sugar_tr PF00083.24 ELR20495.1 - 0.026 13.4 4.0 0.034 13.0 4.0 1.3 1 1 0 1 1 1 0 Sugar (and other) transporter MFS_1 PF07690.16 ELR20496.1 - 4.5e-26 91.6 37.0 5e-13 48.7 8.7 2.8 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.7 ELR20496.1 - 0.00012 21.1 17.8 0.00077 18.4 3.2 3.0 2 1 0 3 3 3 2 MFS_1 like family Pam17 PF08566.10 ELR20496.1 - 6.9 6.5 10.1 8.4 6.2 0.3 3.0 3 0 0 3 3 3 0 Mitochondrial import protein Pam17 Ammonium_transp PF00909.21 ELR20497.1 - 8.5e-53 179.5 20.7 1.2e-52 179.0 20.7 1.2 1 0 0 1 1 1 1 Ammonium Transporter Family TMEM141 PF15110.6 ELR20497.1 - 0.085 13.4 0.1 0.24 12.0 0.1 1.8 1 0 0 1 1 1 0 TMEM141 protein family BOP1NT PF08145.12 ELR20498.1 - 1.5e-77 261.0 17.3 3e-75 253.5 17.3 2.4 1 1 0 1 1 1 1 BOP1NT (NUC169) domain WD40 PF00400.32 ELR20498.1 - 2.2e-27 94.7 0.5 1.3e-08 35.4 0.0 7.0 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ELR20498.1 - 1.7e-07 31.4 0.0 2.7e-05 24.4 0.0 3.3 3 1 1 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain SDA1 PF05285.12 ELR20498.1 - 0.28 10.6 21.8 0.49 9.8 21.8 1.3 1 0 0 1 1 1 0 SDA1 Nop14 PF04147.12 ELR20498.1 - 4.4 5.4 25.2 5.5 5.1 25.2 1.1 1 0 0 1 1 1 0 Nop14-like family DUF3727 PF12527.8 ELR20498.1 - 4.9 7.5 0.0 4.9 7.5 0.0 3.7 3 1 1 4 4 4 0 Protein of unknown function (DUF3727) adh_short_C2 PF13561.6 ELR20499.1 - 7.4e-09 35.5 0.3 9.5e-09 35.1 0.3 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 ELR20499.1 - 2.5e-07 30.4 0.0 3.8e-07 29.8 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase GDP_Man_Dehyd PF16363.5 ELR20499.1 - 0.0012 18.3 0.0 0.0018 17.8 0.0 1.2 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Sacchrp_dh_NADP PF03435.18 ELR20499.1 - 0.002 18.4 0.2 0.0076 16.5 0.0 2.0 2 0 0 2 2 2 1 Saccharopine dehydrogenase NADP binding domain KR PF08659.10 ELR20499.1 - 0.0022 17.9 1.4 0.0035 17.3 0.1 1.8 2 0 0 2 2 2 1 KR domain Epimerase PF01370.21 ELR20499.1 - 0.0041 16.6 0.1 0.0087 15.5 0.1 1.6 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family DAO PF01266.24 ELR20499.1 - 0.051 13.1 0.4 7 6.1 0.0 2.2 1 1 1 2 2 2 0 FAD dependent oxidoreductase THF_DHG_CYH_C PF02882.19 ELR20499.1 - 0.056 12.8 0.0 0.11 11.8 0.0 1.4 1 0 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Shikimate_DH PF01488.20 ELR20499.1 - 0.094 12.8 0.0 0.18 11.8 0.0 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Metallophos PF00149.28 ELR20500.1 - 9.9e-07 29.5 0.0 1.5e-06 28.9 0.0 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase SR-25 PF10500.9 ELR20501.1 - 5.5 6.5 12.5 7.1 6.2 12.5 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein MIP PF00230.20 ELR20502.1 - 1.3e-32 113.4 18.9 9.1e-32 110.6 18.9 1.9 1 1 0 1 1 1 1 Major intrinsic protein RasGEF PF00617.19 ELR20503.1 - 8.9e-39 133.5 0.0 2.2e-38 132.2 0.0 1.6 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 ELR20503.1 - 3.8e-17 62.4 0.0 9.6e-17 61.1 0.0 1.6 1 0 0 1 1 1 1 RasGEF N-terminal motif RGS-like PF09128.11 ELR20503.1 - 1.7 8.4 5.7 4.8 6.8 0.2 2.7 3 0 0 3 3 3 0 Regulator of G protein signalling-like domain UCH PF00443.29 ELR20504.1 - 4.8e-36 124.6 0.0 8.5e-36 123.8 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 ELR20504.1 - 3.3e-17 63.1 0.0 5.5e-17 62.3 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase SAP PF02037.27 ELR20504.1 - 1.2e-07 31.3 2.0 2.1e-07 30.5 2.0 1.5 1 0 0 1 1 1 1 SAP domain SYS1 PF09801.9 ELR20505.1 - 1.3e-39 135.6 12.2 1.5e-39 135.4 12.2 1.0 1 0 0 1 1 1 1 Integral membrane protein S linking to the trans Golgi network DUF4381 PF14316.6 ELR20505.1 - 0.27 11.5 3.7 0.17 12.1 1.7 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4381) SelK_SelG PF10961.8 ELR20506.1 - 3 8.5 11.0 0.25 12.0 0.7 2.7 2 0 0 2 2 2 0 Selenoprotein SelK_SelG RNase_Zc3h12a PF11977.8 ELR20508.1 - 4.6e-24 85.0 0.0 7.9e-24 84.2 0.0 1.3 1 0 0 1 1 1 1 Zc3h12a-like Ribonuclease NYN domain PRORP PF16953.5 ELR20508.1 - 0.009 15.6 0.0 0.02 14.4 0.0 1.4 1 1 0 1 1 1 1 Protein-only RNase P SpoU_methylase PF00588.19 ELR20510.1 - 4.3e-24 85.3 0.0 7.8e-24 84.5 0.0 1.4 1 0 0 1 1 1 1 SpoU rRNA Methylase family SPA PF08616.10 ELR20511.1 - 6.6e-30 103.4 0.0 1.5e-29 102.3 0.0 1.6 1 0 0 1 1 1 1 Stabilization of polarity axis Afi1 PF07792.12 ELR20511.1 - 1.2e-20 74.4 0.0 2.7e-19 70.0 0.0 2.5 1 1 0 1 1 1 1 Docking domain of Afi1 for Arf3 in vesicle trafficking Avl9 PF09794.9 ELR20511.1 - 5.3e-13 48.4 0.0 0.00027 19.8 0.0 3.5 2 1 1 3 3 3 3 Transport protein Avl9 DENN PF02141.21 ELR20511.1 - 0.00031 20.7 0.1 0.00064 19.7 0.1 1.5 1 0 0 1 1 1 1 DENN (AEX-3) domain DUF2347 PF09804.9 ELR20511.1 - 0.0044 16.6 0.0 0.76 9.3 0.0 2.4 2 0 0 2 2 2 2 Uncharacterized conserved protein (DUF2347) OGFr_N PF04664.13 ELR20514.1 - 5.4e-66 222.1 0.6 7.1e-66 221.7 0.6 1.1 1 0 0 1 1 1 1 Opioid growth factor receptor (OGFr) conserved region YL1 PF05764.13 ELR20514.1 - 0.7 10.0 11.8 1.7 8.7 11.9 1.5 1 1 0 1 1 1 0 YL1 nuclear protein Ribosomal_60s PF00428.19 ELR20514.1 - 3.7 8.2 17.8 0.63 10.7 0.2 2.6 1 1 1 2 2 2 0 60s Acidic ribosomal protein DNA_pol_phi PF04931.13 ELR20514.1 - 8.2 4.4 10.6 10 4.1 10.6 1.1 1 0 0 1 1 1 0 DNA polymerase phi MORN PF02493.20 ELR20515.1 - 6.9e-53 173.5 51.1 5.5e-07 29.1 0.8 12.5 12 0 0 12 12 12 11 MORN repeat RhoGEF PF00621.20 ELR20515.1 - 5.9e-29 101.6 2.0 4.8e-28 98.6 2.0 2.0 1 1 0 1 1 1 1 RhoGEF domain PH_16 PF17838.1 ELR20515.1 - 0.0027 17.5 0.0 0.0057 16.5 0.0 1.5 1 0 0 1 1 1 1 PH domain PATR PF12951.7 ELR20515.1 - 0.043 13.9 11.8 0.72 10.0 0.2 4.9 4 0 0 4 4 4 0 Passenger-associated-transport-repeat PH_10 PF15411.6 ELR20515.1 - 0.064 13.5 0.4 0.52 10.6 0.2 2.2 1 1 1 2 2 2 0 Pleckstrin homology domain PH PF00169.29 ELR20515.1 - 0.18 12.3 0.0 0.37 11.3 0.0 1.5 1 0 0 1 1 1 0 PH domain ABC2_membrane_3 PF12698.7 ELR20516.1 - 5.7e-29 101.3 16.2 8.6e-29 100.7 16.2 1.2 1 0 0 1 1 1 1 ABC-2 family transporter protein ABC_tran PF00005.27 ELR20516.1 - 4e-23 82.5 0.0 7.7e-23 81.5 0.0 1.5 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 ELR20516.1 - 0.00029 20.8 0.1 0.31 10.8 0.0 3.2 3 0 0 3 3 3 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_16 PF13191.6 ELR20516.1 - 0.002 18.5 0.0 0.0039 17.6 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain ABC2_membrane PF01061.24 ELR20516.1 - 0.01 15.3 28.5 0.045 13.2 26.6 2.6 2 1 0 2 2 2 1 ABC-2 type transporter Cdc6_C PF09079.11 ELR20516.1 - 0.047 13.7 0.0 0.2 11.6 0.0 2.1 1 0 0 1 1 1 0 CDC6, C terminal winged helix domain AAA_23 PF13476.6 ELR20516.1 - 0.11 13.0 0.1 0.2 12.1 0.1 1.4 1 0 0 1 1 1 0 AAA domain AAA_15 PF13175.6 ELR20516.1 - 0.18 11.5 0.0 4.7 6.8 0.0 2.2 2 0 0 2 2 2 0 AAA ATPase domain ABC2_membrane_2 PF12679.7 ELR20516.1 - 0.35 10.1 14.7 0.72 9.1 14.7 1.4 1 0 0 1 1 1 0 ABC-2 family transporter protein SET PF00856.28 ELR20518.1 - 9.8e-10 39.1 0.0 1.4e-09 38.6 0.0 1.6 1 1 0 1 1 1 1 SET domain NinF PF05810.12 ELR20518.1 - 0.23 11.3 0.1 0.23 11.3 0.1 2.7 4 0 0 4 4 4 0 NinF protein Siva PF05458.12 ELR20518.1 - 0.33 10.6 4.5 0.35 10.5 0.2 2.4 2 0 0 2 2 2 0 Cd27 binding protein (Siva) zf-MYND PF01753.18 ELR20518.1 - 3.4 7.8 14.6 0.14 12.3 3.1 3.2 2 1 1 3 3 3 0 MYND finger RRM_1 PF00076.22 ELR20519.1 - 1.3e-06 28.1 0.0 2.6e-06 27.1 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Pkinase_Tyr PF07714.17 ELR20520.1 - 9.9e-113 375.7 0.0 3.3e-58 197.0 0.0 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 ELR20520.1 - 2.5e-100 335.2 0.0 3.4e-55 187.2 0.0 2.7 2 1 0 2 2 2 2 Protein kinase domain 5_nucleotid_C PF02872.18 ELR20520.1 - 8e-24 84.6 0.0 1.8e-23 83.5 0.0 1.6 1 0 0 1 1 1 1 5'-nucleotidase, C-terminal domain Guanylate_cyc PF00211.20 ELR20520.1 - 3.2e-09 36.7 0.0 1.4e-08 34.6 0.0 1.9 1 1 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain Kinase-like PF14531.6 ELR20520.1 - 5.2e-05 22.7 0.1 0.25 10.6 0.0 2.2 2 0 0 2 2 2 2 Kinase-like Kdo PF06293.14 ELR20520.1 - 9.5e-05 21.8 0.1 0.083 12.2 0.0 2.4 2 0 0 2 2 2 2 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 ELR20520.1 - 0.00018 20.6 0.0 0.0064 15.5 0.0 2.4 2 1 0 2 2 2 1 Haspin like kinase domain APH PF01636.23 ELR20520.1 - 0.0002 21.4 1.9 0.1 12.5 0.0 3.1 3 1 0 3 3 2 2 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 ELR20520.1 - 0.00039 19.3 0.0 0.076 11.8 0.0 2.7 3 0 0 3 3 3 1 Fungal protein kinase SKG6 PF08693.10 ELR20520.1 - 0.003 16.9 1.2 0.003 16.9 1.2 2.7 2 0 0 2 2 2 1 Transmembrane alpha-helix domain TMEM154 PF15102.6 ELR20520.1 - 0.0033 17.3 2.7 0.0076 16.2 0.0 2.3 2 0 0 2 2 2 1 TMEM154 protein family ABC1 PF03109.16 ELR20520.1 - 0.026 14.7 0.1 0.077 13.2 0.0 1.8 2 0 0 2 2 2 0 ABC1 family EGF_2 PF07974.13 ELR20520.1 - 0.038 14.4 7.2 0.093 13.1 7.2 1.7 1 0 0 1 1 1 0 EGF-like domain DUF347 PF03988.12 ELR20520.1 - 0.072 13.3 0.5 0.25 11.6 0.5 2.0 1 0 0 1 1 1 0 Repeat of Unknown Function (DUF347) FTA2 PF13095.6 ELR20520.1 - 0.23 11.0 0.0 0.94 9.1 0.0 2.1 3 0 0 3 3 3 0 Kinetochore Sim4 complex subunit FTA2 EB PF01683.18 ELR20520.1 - 0.74 10.1 4.1 1.5 9.2 4.1 1.5 1 0 0 1 1 1 0 EB module I-EGF_1 PF18372.1 ELR20520.1 - 3.9 7.7 9.9 4.1 7.6 6.4 2.5 2 0 0 2 2 2 0 Integrin beta epidermal growth factor like domain 1 PH PF00169.29 ELR20522.1 - 7.7e-08 32.8 0.1 2.5e-06 27.9 0.0 2.6 2 0 0 2 2 2 1 PH domain PH_6 PF15406.6 ELR20522.1 - 5.3e-07 29.9 0.0 2e-06 28.1 0.0 2.0 1 0 0 1 1 1 1 Pleckstrin homology domain PH_3 PF14593.6 ELR20522.1 - 9.1e-05 22.5 0.1 0.00017 21.6 0.1 1.4 1 0 0 1 1 1 1 PH domain PH_13 PF16652.5 ELR20522.1 - 0.013 15.3 1.2 0.028 14.2 1.2 1.4 1 0 0 1 1 1 0 Pleckstrin homology domain CagX PF03524.15 ELR20522.1 - 0.13 11.9 0.1 0.23 11.1 0.1 1.3 1 0 0 1 1 1 0 Conjugal transfer protein PPP4R2 PF09184.11 ELR20522.1 - 0.46 10.0 15.4 0.98 8.9 15.4 1.5 1 0 0 1 1 1 0 PPP4R2 Nop14 PF04147.12 ELR20522.1 - 0.98 7.5 18.3 2.2 6.4 18.3 1.5 1 0 0 1 1 1 0 Nop14-like family UPF0560 PF10577.9 ELR20522.1 - 1.6 7.2 4.7 3.2 6.2 4.7 1.4 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 Cwf_Cwc_15 PF04889.12 ELR20522.1 - 8.8 6.0 28.6 0.44 10.2 18.5 2.6 3 0 0 3 3 3 0 Cwf15/Cwc15 cell cycle control protein GST_N_3 PF13417.6 ELR20524.1 - 5.4e-19 68.4 0.0 9.5e-19 67.6 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 ELR20524.1 - 5.6e-15 55.4 0.0 1e-14 54.5 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_5 PF16865.5 ELR20524.1 - 2.6e-12 47.3 0.0 3.6e-12 46.8 0.0 1.2 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 ELR20524.1 - 1.7e-10 41.1 0.0 7.1e-10 39.1 0.0 2.0 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 ELR20524.1 - 2.7e-07 30.7 0.1 4.6e-07 29.9 0.1 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 ELR20524.1 - 3.7e-07 30.1 0.1 7.3e-07 29.1 0.1 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 ELR20524.1 - 4.4e-07 30.0 0.0 7.6e-07 29.3 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Glutaredoxin PF00462.24 ELR20524.1 - 0.0064 16.7 0.0 0.016 15.4 0.0 1.7 1 0 0 1 1 1 1 Glutaredoxin SLX9 PF15341.6 ELR20527.1 - 0.022 15.1 1.5 0.054 13.9 1.5 1.6 1 0 0 1 1 1 0 Ribosome biogenesis protein SLX9 Mit_KHE1 PF10173.9 ELR20527.1 - 0.055 13.6 0.3 0.092 12.8 0.3 1.3 1 0 0 1 1 1 0 Mitochondrial K+-H+ exchange-related DUF3774 PF12609.8 ELR20527.1 - 7.3 7.7 7.5 0.9 10.6 1.3 2.5 2 0 0 2 2 2 0 Wound-induced protein RsgA_GTPase PF03193.16 ELR20528.1 - 0.0032 17.4 0.0 3.2 7.6 0.0 2.4 2 0 0 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 ELR20528.1 - 0.026 14.6 0.0 0.053 13.6 0.0 1.6 1 0 0 1 1 1 0 50S ribosome-binding GTPase DUF2807 PF10988.8 ELR20528.1 - 0.2 11.4 0.0 0.32 10.8 0.0 1.3 1 0 0 1 1 1 0 Putative auto-transporter adhesin, head GIN domain Peptidase_C97 PF05903.14 ELR20530.1 - 8.7e-30 103.6 0.0 1.4e-29 102.9 0.0 1.3 1 0 0 1 1 1 1 PPPDE putative peptidase domain UBX PF00789.20 ELR20530.1 - 8.7e-14 51.5 0.0 1.4e-13 50.8 0.0 1.3 1 0 0 1 1 1 1 UBX domain DUF2183 PF09949.9 ELR20531.1 - 7.5e-33 112.8 0.0 1.5e-32 111.9 0.0 1.5 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2183) G-patch PF01585.23 ELR20531.1 - 0.00019 21.2 0.9 0.00052 19.8 0.9 1.7 1 0 0 1 1 1 1 G-patch domain DUF5130 PF17174.4 ELR20531.1 - 0.087 13.0 0.0 0.21 11.8 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF5130) MMR_HSR1 PF01926.23 ELR20532.1 - 8.8e-20 70.9 0.1 1.4e-19 70.3 0.1 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 ELR20532.1 - 4.8e-09 35.9 0.2 7.5e-09 35.3 0.2 1.3 1 0 0 1 1 1 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 ELR20532.1 - 4e-08 33.3 0.7 0.0026 17.7 0.1 2.2 2 0 0 2 2 2 2 RsgA GTPase KH_2 PF07650.17 ELR20532.1 - 1.3e-07 31.3 1.3 2.8e-07 30.3 1.3 1.6 1 0 0 1 1 1 1 KH domain GTP_EFTU PF00009.27 ELR20532.1 - 1.4e-07 31.2 0.1 3.4e-06 26.7 0.1 2.4 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Dynamin_N PF00350.23 ELR20532.1 - 2.6e-07 30.9 1.0 0.00031 20.8 0.1 2.2 1 1 1 2 2 2 2 Dynamin family PduV-EutP PF10662.9 ELR20532.1 - 3.8e-06 26.7 0.0 3.4e-05 23.6 0.0 2.3 1 1 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation Arf PF00025.21 ELR20532.1 - 0.0001 21.8 0.2 0.24 10.9 0.1 2.2 2 0 0 2 2 2 2 ADP-ribosylation factor family AIG1 PF04548.16 ELR20532.1 - 0.00078 18.8 0.0 0.0011 18.3 0.0 1.3 1 0 0 1 1 1 1 AIG1 family Roc PF08477.13 ELR20532.1 - 0.0093 16.2 0.1 0.11 12.7 0.1 2.2 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1_Xtn PF16897.5 ELR20532.1 - 0.012 15.6 0.3 0.072 13.1 0.1 2.3 2 1 0 2 2 1 0 C-terminal region of MMR_HSR1 domain cobW PF02492.19 ELR20532.1 - 0.039 13.6 0.8 0.22 11.1 0.3 2.0 1 1 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain SRPRB PF09439.10 ELR20532.1 - 0.064 12.7 0.0 0.14 11.6 0.0 1.5 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit AAA_16 PF13191.6 ELR20532.1 - 0.074 13.4 0.6 0.26 11.7 0.6 1.9 1 1 0 1 1 1 0 AAA ATPase domain Gtr1_RagA PF04670.12 ELR20532.1 - 0.086 12.2 0.0 0.15 11.4 0.0 1.3 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region AAA_28 PF13521.6 ELR20532.1 - 0.1 12.9 0.1 0.38 11.0 0.0 1.9 1 1 1 2 2 2 0 AAA domain ABG_transport PF03806.13 ELR20532.1 - 0.11 10.7 0.0 0.16 10.2 0.0 1.2 1 0 0 1 1 1 0 AbgT putative transporter family RasGEF PF00617.19 ELR20533.1 - 5e-51 173.4 0.7 5e-51 173.4 0.7 1.4 2 0 0 2 2 2 1 RasGEF domain NNMT_PNMT_TEMT PF01234.17 ELR20533.1 - 0.0072 15.5 0.2 0.046 12.9 0.1 2.0 1 1 1 2 2 2 1 NNMT/PNMT/TEMT family DHBP_synthase PF00926.19 ELR20533.1 - 0.057 12.9 0.1 0.13 11.8 0.0 1.7 2 0 0 2 2 2 0 3,4-dihydroxy-2-butanone 4-phosphate synthase DUF2514 PF10721.9 ELR20533.1 - 2.1 8.4 10.2 1 9.4 7.5 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2514) RasGEF_N PF00618.20 ELR20534.1 - 0.00024 21.3 1.0 0.00047 20.4 0.0 2.0 2 0 0 2 2 2 1 RasGEF N-terminal motif CCER1 PF15482.6 ELR20534.1 - 0.5 10.2 4.3 1.5 8.7 4.3 1.9 1 0 0 1 1 1 0 Coiled-coil domain-containing glutamate-rich protein family 1 Ank_4 PF13637.6 ELR20535.1 - 6e-07 29.9 1.1 0.13 12.9 0.1 4.0 1 1 2 3 3 3 3 Ankyrin repeats (many copies) F-box PF00646.33 ELR20535.1 - 3.3e-06 26.8 0.2 6.4e-06 25.9 0.2 1.4 1 0 0 1 1 1 1 F-box domain Ank_5 PF13857.6 ELR20535.1 - 0.00023 21.4 5.3 2.6 8.5 0.1 5.1 6 0 0 6 6 6 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 ELR20535.1 - 0.00027 21.4 0.3 0.36 11.5 0.1 2.9 1 1 0 2 2 2 2 Ankyrin repeats (3 copies) HTH_47 PF16221.5 ELR20535.1 - 0.0018 17.8 0.0 4.8 6.8 0.0 4.3 1 1 4 5 5 5 1 winged helix-turn-helix Smoa_sbd PF17885.1 ELR20535.1 - 0.03 14.4 0.1 1.7 8.8 0.0 2.8 1 1 1 3 3 3 0 Styrene monooxygenase A putative substrate binding domain TerY_C PF15616.6 ELR20535.1 - 1.8 8.7 6.5 2.1 8.5 0.2 2.9 1 1 2 3 3 3 0 TerY-C metal binding domain CPSase_L_D2 PF02786.17 ELR20536.1 - 1.8e-79 266.2 0.2 2.8e-79 265.5 0.2 1.3 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Biotin_carb_N PF00289.22 ELR20536.1 - 1.4e-46 157.6 0.1 6.8e-46 155.4 0.0 2.1 2 0 0 2 2 2 1 Biotin carboxylase, N-terminal domain Biotin_carb_C PF02785.19 ELR20536.1 - 9.4e-36 122.2 0.0 2.6e-35 120.8 0.0 1.8 1 0 0 1 1 1 1 Biotin carboxylase C-terminal domain Biotin_lipoyl PF00364.22 ELR20536.1 - 3e-17 62.2 4.3 6.4e-17 61.1 2.5 2.5 2 0 0 2 2 2 1 Biotin-requiring enzyme Dala_Dala_lig_C PF07478.13 ELR20536.1 - 7.9e-10 38.6 0.2 1.9e-09 37.3 0.2 1.6 1 1 0 1 1 1 1 D-ala D-ala ligase C-terminus ATP-grasp PF02222.22 ELR20536.1 - 6.7e-09 35.5 0.3 1.4e-08 34.5 0.3 1.5 1 0 0 1 1 1 1 ATP-grasp domain Biotin_lipoyl_2 PF13533.6 ELR20536.1 - 1.4e-06 28.1 3.2 0.00024 20.9 0.0 3.0 2 1 1 3 3 3 2 Biotin-lipoyl like ATP-grasp_3 PF02655.14 ELR20536.1 - 1.5e-05 25.1 0.1 3.1e-05 24.1 0.1 1.6 1 0 0 1 1 1 1 ATP-grasp domain RimK PF08443.11 ELR20536.1 - 0.00038 20.1 0.0 0.0011 18.7 0.0 1.7 1 1 0 1 1 1 1 RimK-like ATP-grasp domain RnfC_N PF13375.6 ELR20536.1 - 0.00044 20.2 0.2 0.0096 15.9 0.2 2.7 2 0 0 2 2 2 1 RnfC Barrel sandwich hybrid domain HlyD_3 PF13437.6 ELR20536.1 - 0.00081 20.1 0.9 1.2 9.9 0.4 3.1 3 0 0 3 3 3 2 HlyD family secretion protein GARS_A PF01071.19 ELR20536.1 - 0.0039 17.0 0.1 0.0068 16.2 0.1 1.4 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain NQRA PF05896.11 ELR20536.1 - 0.011 15.2 0.3 0.023 14.2 0.3 1.4 1 0 0 1 1 1 0 Na(+)-translocating NADH-quinone reductase subunit A (NQRA) HlyD_D23 PF16576.5 ELR20536.1 - 0.018 14.3 0.8 0.46 9.7 0.0 2.7 2 1 1 3 3 3 0 Barrel-sandwich domain of CusB or HlyD membrane-fusion PTS_EIIA_1 PF00358.20 ELR20536.1 - 0.04 13.7 0.0 0.24 11.2 0.0 2.3 1 1 1 2 2 2 0 phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1 ATP-grasp_4 PF13535.6 ELR20536.1 - 0.048 13.3 0.0 0.092 12.3 0.0 1.5 1 0 0 1 1 1 0 ATP-grasp domain ATPgrasp_ST PF14397.6 ELR20536.1 - 0.049 12.9 0.1 0.17 11.1 0.0 1.8 2 0 0 2 2 2 0 Sugar-transfer associated ATP-grasp GCV_H PF01597.19 ELR20536.1 - 0.055 13.4 0.1 0.14 12.0 0.1 1.7 1 0 0 1 1 1 0 Glycine cleavage H-protein LRR_4 PF12799.7 ELR20537.1 - 5.7e-14 52.0 6.5 0.00018 21.8 0.2 6.0 3 1 3 6 6 6 5 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 ELR20537.1 - 1.6e-08 34.1 15.2 0.00062 19.5 5.2 5.4 5 2 0 5 5 5 2 Leucine rich repeat LRR_6 PF13516.6 ELR20537.1 - 0.004 17.1 17.5 1.4 9.1 0.0 7.5 9 0 0 9 9 9 3 Leucine Rich repeat LRR_1 PF00560.33 ELR20537.1 - 0.62 10.8 11.8 77 4.5 0.3 6.6 6 2 0 6 6 6 0 Leucine Rich Repeat Ank_5 PF13857.6 ELR20538.1 - 1.1e-17 63.9 1.0 1e-07 32.1 0.0 4.2 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 ELR20538.1 - 1.7e-17 63.8 0.0 4.4e-07 30.4 0.0 2.8 2 1 0 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.30 ELR20538.1 - 1.7e-16 59.8 0.6 0.00014 22.1 0.0 4.7 5 0 0 5 5 5 3 Ankyrin repeat Ank_4 PF13637.6 ELR20538.1 - 5.3e-15 55.6 1.6 8.1e-06 26.3 0.0 3.5 2 1 2 4 4 4 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 ELR20538.1 - 3e-14 51.7 0.1 0.0015 18.9 0.0 4.5 4 0 0 4 4 4 4 Ankyrin repeat PAS PF00989.25 ELR20539.1 - 0.0041 17.1 0.0 0.0041 17.1 0.0 2.5 4 0 0 4 4 4 1 PAS fold PAS_3 PF08447.12 ELR20539.1 - 0.007 16.6 0.0 0.021 15.1 0.0 1.9 1 1 0 1 1 1 1 PAS fold PAS_8 PF13188.7 ELR20539.1 - 0.056 13.5 0.0 0.21 11.7 0.0 1.9 2 0 0 2 2 2 0 PAS domain Gemini_coat PF00844.18 ELR20539.1 - 0.069 12.6 1.6 0.16 11.4 1.6 1.6 1 0 0 1 1 1 0 Geminivirus coat protein/nuclear export factor BR1 family PAS_9 PF13426.7 ELR20539.1 - 0.1 12.9 0.0 0.35 11.2 0.0 1.9 2 0 0 2 2 2 0 PAS domain RasGAP_C PF03836.15 ELR20539.1 - 0.47 10.6 5.4 1.1 9.4 5.4 1.6 1 0 0 1 1 1 0 RasGAP C-terminus Ferlin_C PF16165.5 ELR20539.1 - 1.7 8.6 5.1 3.5 7.6 0.2 2.2 2 0 0 2 2 2 0 Ferlin C-terminus PAS_3 PF08447.12 ELR20540.1 - 8.7e-05 22.7 0.6 0.00031 21.0 0.0 2.2 2 0 0 2 2 2 1 PAS fold PAS PF00989.25 ELR20540.1 - 0.0044 17.0 0.0 0.015 15.3 0.0 1.9 2 0 0 2 2 2 1 PAS fold Zn_clus PF00172.18 ELR20540.1 - 0.024 14.8 14.3 0.049 13.8 14.3 1.5 1 0 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain PAS_9 PF13426.7 ELR20540.1 - 0.03 14.6 0.0 0.064 13.5 0.0 1.5 1 0 0 1 1 1 0 PAS domain PAS_8 PF13188.7 ELR20540.1 - 0.031 14.3 0.0 0.094 12.8 0.0 1.8 1 0 0 1 1 1 0 PAS domain PAS_4 PF08448.10 ELR20540.1 - 0.093 13.0 0.7 1.1 9.6 0.0 2.5 2 0 0 2 2 2 0 PAS fold Oxysterol_BP PF01237.18 ELR20540.1 - 0.12 11.2 0.7 0.17 10.7 0.7 1.3 1 0 0 1 1 1 0 Oxysterol-binding protein Spc7 PF08317.11 ELR20540.1 - 0.38 9.6 4.4 0.71 8.7 4.4 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein DivIVA PF05103.13 ELR20540.1 - 0.4 10.8 7.1 1 9.5 7.1 1.6 1 0 0 1 1 1 0 DivIVA protein DUF1168 PF06658.12 ELR20540.1 - 0.7 9.7 15.7 0.93 9.3 3.7 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1168) MAP65_ASE1 PF03999.12 ELR20540.1 - 1.2 7.8 8.8 3.4 6.2 2.9 2.1 2 0 0 2 2 2 0 Microtubule associated protein (MAP65/ASE1 family) NST1 PF13945.6 ELR20540.1 - 1.3 9.1 13.8 1.1 9.4 8.1 2.2 2 0 0 2 2 2 0 Salt tolerance down-regulator BRF1 PF07741.13 ELR20540.1 - 1.7 9.0 12.0 5.7 7.3 1.7 2.4 2 0 0 2 2 2 0 Brf1-like TBP-binding domain DUF3439 PF11921.8 ELR20540.1 - 1.8 8.5 12.0 0.4 10.6 7.9 2.0 2 1 0 2 2 2 0 Domain of unknown function (DUF3439) PAS_9 PF13426.7 ELR20541.1 - 1.7e-09 37.8 0.0 0.00056 20.1 0.0 2.6 2 0 0 2 2 2 2 PAS domain PAS PF00989.25 ELR20541.1 - 1.5e-08 34.6 0.0 0.0035 17.3 0.0 3.0 3 0 0 3 3 3 2 PAS fold PAS_3 PF08447.12 ELR20541.1 - 2.6e-05 24.4 0.0 0.02 15.2 0.0 3.4 2 2 0 2 2 2 1 PAS fold PAS_8 PF13188.7 ELR20541.1 - 0.0038 17.2 0.0 3 8.0 0.0 2.8 2 0 0 2 2 2 1 PAS domain ZapB PF06005.12 ELR20541.1 - 0.0072 16.8 6.2 0.15 12.5 0.0 2.7 2 0 0 2 2 2 1 Cell division protein ZapB CLZ PF16526.5 ELR20541.1 - 0.0075 16.6 12.1 0.046 14.1 1.9 2.4 2 0 0 2 2 2 2 C-terminal leucine zipper domain of cyclic nucleotide-gated channels PAS_11 PF14598.6 ELR20541.1 - 0.013 15.6 0.1 0.18 11.9 0.0 2.6 2 0 0 2 2 2 0 PAS domain DUF1664 PF07889.12 ELR20541.1 - 0.057 13.5 3.3 6.4 6.8 0.6 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) GreA_GreB_N PF03449.15 ELR20541.1 - 0.074 13.2 0.1 0.24 11.6 0.1 1.8 1 0 0 1 1 1 0 Transcription elongation factor, N-terminal DUF812 PF05667.11 ELR20541.1 - 0.15 10.9 8.3 1.1 8.1 0.5 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF812) YabA PF06156.13 ELR20541.1 - 0.16 12.6 1.7 33 5.2 0.0 2.5 2 0 0 2 2 2 0 Initiation control protein YabA Ax_dynein_light PF10211.9 ELR20541.1 - 0.31 11.0 9.6 0.25 11.3 1.3 2.3 2 0 0 2 2 2 0 Axonemal dynein light chain Fib_alpha PF08702.10 ELR20541.1 - 0.5 10.5 8.7 4.6 7.4 1.0 2.3 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family Dynamitin PF04912.14 ELR20541.1 - 0.55 9.5 7.5 0.15 11.3 0.5 2.1 2 0 0 2 2 2 0 Dynamitin bZIP_1 PF00170.21 ELR20541.1 - 0.56 10.3 7.5 5.1 7.3 0.1 2.7 3 0 0 3 3 2 0 bZIP transcription factor FlaC_arch PF05377.11 ELR20541.1 - 0.82 10.1 3.5 3.6 8.1 0.6 2.3 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) Tropomyosin_1 PF12718.7 ELR20541.1 - 1.4 9.1 8.0 0.23 11.6 0.4 2.2 2 0 0 2 2 2 0 Tropomyosin like CHDCT2 PF08074.11 ELR20541.1 - 1.4 9.1 7.2 4.1 7.5 1.6 2.3 2 0 0 2 2 2 0 CHDCT2 (NUC038) domain APG6_N PF17675.1 ELR20541.1 - 1.8 9.1 11.9 7.9 7.0 2.8 2.3 2 0 0 2 2 2 0 Apg6 coiled-coil region Syntaxin-6_N PF09177.11 ELR20541.1 - 1.9 9.1 4.7 6.2 7.4 0.4 2.5 2 0 0 2 2 2 0 Syntaxin 6, N-terminal Wtap PF17098.5 ELR20541.1 - 2.8 7.8 8.8 1.8 8.5 2.2 2.3 2 0 0 2 2 2 0 WTAP/Mum2p family DUF5082 PF16888.5 ELR20541.1 - 5.7 7.2 6.0 13 6.1 0.6 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF5082) CENP-H PF05837.12 ELR20541.1 - 8.2 6.9 8.8 5.2 7.5 1.6 2.4 2 0 0 2 2 2 0 Centromere protein H (CENP-H) DUF4407 PF14362.6 ELR20541.1 - 8.5 5.6 7.9 6.6 6.0 0.5 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) NlpE PF04170.12 ELR20542.1 - 0.048 14.6 0.0 0.15 13.0 0.0 1.6 1 1 1 2 2 2 0 NlpE N-terminal domain Phage_min_cap2 PF06152.11 ELR20542.1 - 0.055 12.4 0.1 0.061 12.2 0.1 1.1 1 0 0 1 1 1 0 Phage minor capsid protein 2 LCAT PF02450.15 ELR20543.1 - 4.4e-37 128.2 0.1 2.4e-34 119.2 0.4 2.1 1 1 0 2 2 2 2 Lecithin:cholesterol acyltransferase LRR_8 PF13855.6 ELR20544.1 - 5.2e-12 45.4 8.3 5.6e-06 26.0 0.7 5.1 2 1 4 6 6 6 4 Leucine rich repeat LRR_4 PF12799.7 ELR20544.1 - 2.2e-05 24.7 5.5 0.00028 21.2 0.1 4.1 3 1 2 5 5 5 1 Leucine Rich repeats (2 copies) TRP PF06011.12 ELR20544.1 - 0.00045 19.1 8.2 0.00045 19.1 8.2 2.6 2 1 1 3 3 3 1 Transient receptor potential (TRP) ion channel LRR_6 PF13516.6 ELR20544.1 - 0.0036 17.2 4.5 0.6 10.3 0.1 4.7 7 0 0 7 7 7 1 Leucine Rich repeat SUa-2TM PF18179.1 ELR20544.1 - 0.012 14.9 0.0 0.031 13.6 0.0 1.6 1 0 0 1 1 1 0 SMODS- and Ubiquitin system-associated 2TM effector domain LRR_1 PF00560.33 ELR20544.1 - 0.088 13.4 8.0 5 8.1 0.0 6.3 7 0 0 7 7 7 0 Leucine Rich Repeat zf-C3HC4_3 PF13920.6 ELR20545.1 - 3.5e-14 52.4 13.3 6.8e-14 51.5 13.3 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 ELR20545.1 - 1.6e-06 27.9 13.5 1.6e-06 27.9 13.5 1.8 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 K-box PF01486.17 ELR20545.1 - 0.00012 22.1 7.9 0.00012 22.1 7.9 1.6 2 0 0 2 2 2 1 K-box region zf-RING_2 PF13639.6 ELR20545.1 - 0.0061 16.9 14.7 0.018 15.4 14.7 1.8 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.6 ELR20545.1 - 0.043 13.8 14.3 0.13 12.2 14.3 1.9 1 0 0 1 1 1 0 zinc-RING finger domain ETC_C1_NDUFA4 PF04800.12 ELR20545.1 - 0.092 13.0 0.0 0.23 11.7 0.0 1.6 1 0 0 1 1 1 0 ETC complex I subunit conserved region SKA2 PF16740.5 ELR20546.1 - 6.6e-19 67.7 2.3 8.6e-19 67.3 2.3 1.1 1 0 0 1 1 1 1 Spindle and kinetochore-associated protein 2 PORR PF11955.8 ELR20546.1 - 0.0093 15.0 0.4 0.01 14.8 0.4 1.0 1 0 0 1 1 1 1 Plant organelle RNA recognition domain UPF0242 PF06785.11 ELR20546.1 - 0.062 13.4 0.9 0.09 12.9 0.9 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus SBDS PF01172.18 ELR20547.1 - 5e-33 113.0 1.8 1.2e-32 111.8 1.4 1.9 2 0 0 2 2 2 1 Shwachman-Bodian-Diamond syndrome (SBDS) protein SBDS_C PF09377.10 ELR20547.1 - 1.2e-32 112.3 0.4 1.2e-32 112.3 0.4 1.9 2 1 0 2 2 2 1 SBDS protein C-terminal domain T3SS_NleG PF06416.12 ELR20547.1 - 0.0025 17.7 0.0 3.5 7.6 0.0 2.8 3 0 0 3 3 3 2 Effector protein NleG MORN PF02493.20 ELR20548.1 - 8.7e-30 100.8 26.2 1.5e-08 34.1 1.2 7.5 7 0 0 7 7 7 6 MORN repeat Tcp10_C PF07202.13 ELR20548.1 - 0.017 15.1 0.4 0.14 12.1 0.0 2.1 2 0 0 2 2 2 0 T-complex protein 10 C-terminus Peptidase_S55 PF05580.12 ELR20548.1 - 0.17 11.8 3.3 12 5.8 0.1 2.9 1 1 2 3 3 3 0 SpoIVB peptidase S55 Nop PF01798.18 ELR20549.1 - 7.6e-15 55.0 0.0 2.9e-14 53.1 0.0 1.8 1 1 0 1 1 1 1 snoRNA binding domain, fibrillarin NOP5NT PF08156.13 ELR20549.1 - 0.0014 18.9 0.0 0.0032 17.8 0.0 1.6 1 0 0 1 1 1 1 NOP5NT (NUC127) domain F-box-like PF12937.7 ELR20549.1 - 0.0028 17.5 0.2 0.0088 15.9 0.2 1.9 1 0 0 1 1 1 1 F-box-like SDA1 PF05285.12 ELR20549.1 - 1 8.7 6.3 1.6 8.1 6.3 1.2 1 0 0 1 1 1 0 SDA1 Cwf_Cwc_15 PF04889.12 ELR20549.1 - 7.1 6.3 7.9 13 5.5 7.9 1.3 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein RhoGEF PF00621.20 ELR20550.1 - 1.3e-31 110.3 11.2 2.5e-31 109.3 11.2 1.5 1 0 0 1 1 1 1 RhoGEF domain IQ_SEC7_PH PF16453.5 ELR20550.1 - 0.00012 22.1 0.0 0.00034 20.6 0.0 1.7 1 0 0 1 1 1 1 PH domain PH PF00169.29 ELR20550.1 - 0.00026 21.4 0.0 0.00075 20.0 0.0 1.8 1 0 0 1 1 1 1 PH domain DUF3399 PF11879.8 ELR20550.1 - 0.19 12.1 0.1 0.19 12.1 0.1 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF3399) DUF5340 PF17275.2 ELR20550.1 - 0.87 9.8 3.1 0.88 9.7 0.8 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF5340) Mannosyl_trans PF05007.13 ELR20553.1 - 9.3e-77 258.4 32.3 1e-38 133.7 6.2 2.1 2 0 0 2 2 2 2 Mannosyltransferase (PIG-M) PIG-U PF06728.13 ELR20553.1 - 1.2e-20 73.9 3.0 1.2e-20 73.9 3.0 2.2 2 0 0 2 2 2 1 GPI transamidase subunit PIG-U GT87 PF09594.10 ELR20553.1 - 0.00065 19.5 18.8 0.00065 19.5 18.8 3.4 2 1 1 3 3 3 1 Glycosyltransferase family 87 Ctf8 PF09696.10 ELR20554.1 - 7.3e-12 45.8 0.1 9.5e-10 39.0 0.0 2.1 1 1 1 2 2 2 2 Ctf8 PAS_9 PF13426.7 ELR20555.1 - 0.001 19.3 0.0 0.0021 18.3 0.0 1.5 1 0 0 1 1 1 1 PAS domain Zn_clus PF00172.18 ELR20555.1 - 0.0036 17.4 11.7 0.0063 16.6 11.7 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain ZapB PF06005.12 ELR20555.1 - 0.017 15.5 4.8 0.017 15.5 4.8 2.3 2 0 0 2 2 2 0 Cell division protein ZapB PAS_8 PF13188.7 ELR20555.1 - 0.039 14.0 0.0 0.41 10.7 0.0 2.3 1 1 1 2 2 2 0 PAS domain YabA PF06156.13 ELR20555.1 - 0.056 14.1 0.2 0.056 14.1 0.2 2.0 2 0 0 2 2 2 0 Initiation control protein YabA PAS PF00989.25 ELR20555.1 - 0.072 13.1 0.2 0.17 11.9 0.0 1.7 2 0 0 2 2 2 0 PAS fold DivIC PF04977.15 ELR20555.1 - 0.13 12.0 0.0 0.13 12.0 0.0 2.6 2 0 0 2 2 2 0 Septum formation initiator ADIP PF11559.8 ELR20555.1 - 2.1 8.4 7.6 0.29 11.2 0.6 2.2 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding MtrG PF04210.13 ELR20556.1 - 0.18 11.7 0.1 0.39 10.6 0.1 1.5 1 0 0 1 1 1 0 Tetrahydromethanopterin S-methyltransferase, subunit G DUF4519 PF15012.6 ELR20557.1 - 0.47 10.7 1.9 1 9.6 1.9 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4519) G-patch PF01585.23 ELR20558.1 - 1.7e-07 31.0 0.1 3.8e-07 29.9 0.1 1.7 1 0 0 1 1 1 1 G-patch domain GAGA_bind PF06217.12 ELR20558.1 - 0.018 15.3 2.7 0.021 15.1 2.7 1.2 1 0 0 1 1 1 0 GAGA binding protein-like family AAA_11 PF13086.6 ELR20558.1 - 0.023 14.5 0.8 0.026 14.3 0.8 1.2 1 0 0 1 1 1 0 AAA domain CTNNB1_binding PF08347.11 ELR20558.1 - 0.025 14.8 3.4 1 9.5 1.8 2.6 2 1 1 3 3 3 0 N-terminal CTNNB1 binding RR_TM4-6 PF06459.12 ELR20558.1 - 0.15 11.8 4.2 0.22 11.3 4.2 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 RNA_polI_A34 PF08208.11 ELR20558.1 - 0.31 11.1 14.5 0.56 10.3 11.8 2.0 2 0 0 2 2 2 0 DNA-directed RNA polymerase I subunit RPA34.5 Med19 PF10278.9 ELR20558.1 - 1.1 9.2 17.3 1.7 8.6 17.3 1.2 1 0 0 1 1 1 0 Mediator of RNA pol II transcription subunit 19 DUF3464 PF11947.8 ELR20558.1 - 1.3 8.8 7.2 2.2 8.0 7.2 1.4 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 Peptidase_S49_N PF08496.10 ELR20558.1 - 5.2 7.1 9.3 8 6.5 9.3 1.2 1 0 0 1 1 1 0 Peptidase family S49 N-terminal WD40 PF00400.32 ELR20559.1 - 6.1e-15 55.4 4.4 1.8e-06 28.6 0.0 5.8 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ELR20559.1 - 0.00044 20.5 0.8 0.97 9.8 0.0 4.0 4 1 1 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain F-box-like PF12937.7 ELR20559.1 - 0.0047 16.8 0.1 0.013 15.4 0.1 1.7 1 0 0 1 1 1 1 F-box-like DUF3827 PF12877.7 ELR20559.1 - 8.4 4.6 9.8 19 3.4 9.8 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3827) PQ-loop PF04193.14 ELR20560.1 - 3.4e-19 68.4 10.2 5.6e-15 54.9 2.2 3.0 4 0 0 4 4 4 2 PQ loop repeat Bac_export_2 PF01312.19 ELR20560.1 - 0.78 8.9 4.4 1 8.5 4.4 1.2 1 0 0 1 1 1 0 FlhB HrpN YscU SpaS Family Mito_carr PF00153.27 ELR20561.1 - 7.8e-63 208.4 1.7 2.6e-21 75.3 0.1 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 ELR20561.1 - 0.38 9.9 5.1 2.6 7.1 0.1 3.4 2 2 1 4 4 4 0 Gammaproteobacterial serine protease Insulin_TMD PF17870.1 ELR20562.1 - 0.094 12.8 0.5 0.22 11.6 0.5 1.6 1 0 0 1 1 1 0 Insulin receptor trans-membrane segment Ras PF00071.22 ELR20563.1 - 3.6e-15 55.9 0.1 6.5e-15 55.1 0.1 1.4 1 1 0 1 1 1 1 Ras family Ank_2 PF12796.7 ELR20563.1 - 8e-14 52.0 1.9 2.3e-06 28.1 0.0 3.3 3 0 0 3 3 3 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ELR20563.1 - 2.1e-10 40.9 0.4 4.5e-05 23.9 0.0 3.0 3 0 0 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 ELR20563.1 - 3.4e-08 33.1 2.3 0.0038 17.6 0.1 4.1 4 0 0 4 4 4 2 Ankyrin repeat Ank PF00023.30 ELR20563.1 - 3.7e-06 27.1 10.0 0.0014 19.0 0.2 4.4 5 1 0 5 5 5 2 Ankyrin repeat Ank_5 PF13857.6 ELR20563.1 - 1.2e-05 25.5 0.2 0.0089 16.3 0.0 2.6 2 0 0 2 2 2 2 Ankyrin repeats (many copies) DUF2520 PF10728.9 ELR20563.1 - 0.0019 18.0 0.0 0.0047 16.7 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF2520) zinc_ribbon_6 PF14599.6 ELR20563.1 - 0.083 12.9 1.5 0.14 12.2 0.1 2.1 2 0 0 2 2 2 0 Zinc-ribbon Ras PF00071.22 ELR20564.1 - 3.5e-29 101.5 0.0 5e-29 101.0 0.0 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR20564.1 - 0.00024 21.3 0.0 0.002 18.3 0.0 2.1 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase RalF_SCD PF18248.1 ELR20564.1 - 0.054 13.5 0.0 0.1 12.5 0.0 1.4 1 1 0 1 1 1 0 RalF C-terminal Sec-7 capping domain adh_short_C2 PF13561.6 ELR20565.1 - 1.4e-58 198.3 2.8 1.6e-58 198.0 2.8 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 ELR20565.1 - 1.7e-50 171.2 0.2 2.1e-50 170.9 0.2 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 ELR20565.1 - 2e-15 57.1 0.6 2.9e-15 56.7 0.6 1.2 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.6 ELR20565.1 - 2.5e-05 24.2 0.8 5.6e-05 23.1 0.8 1.6 1 1 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 ELR20565.1 - 0.00059 19.4 0.2 0.01 15.3 0.2 2.0 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 ELR20565.1 - 0.084 12.2 0.0 1.9 7.8 0.0 2.0 2 0 0 2 2 2 0 GDP-mannose 4,6 dehydratase 3HCDH_N PF02737.18 ELR20565.1 - 0.15 11.9 0.4 2.8 7.8 0.2 2.1 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Spore_coat_CotO PF14153.6 ELR20566.1 - 1.3 8.9 9.3 2.3 8.1 9.3 1.4 1 0 0 1 1 1 0 Spore coat protein CotO F-box-like PF12937.7 ELR20567.1 - 0.0018 18.2 0.8 0.026 14.4 0.8 3.1 1 1 0 1 1 1 1 F-box-like Phage_Gp23 PF10669.9 ELR20567.1 - 0.23 11.8 0.3 1.5 9.2 0.0 2.5 2 0 0 2 2 2 0 Protein gp23 (Bacteriophage A118) FXR_C1 PF16096.5 ELR20567.1 - 2.1 8.6 4.7 4.3 7.6 4.7 1.4 1 0 0 1 1 1 0 Fragile X-related 1 protein C-terminal region 2 PTH2 PF01981.16 ELR20568.1 - 1.3e-28 99.6 0.1 6.8e-28 97.3 0.1 1.9 1 1 0 1 1 1 1 Peptidyl-tRNA hydrolase PTH2 FixH PF05751.11 ELR20569.1 - 0.85 9.6 0.0 0.85 9.6 0.0 2.2 4 0 0 4 4 4 0 FixH MgtE PF01769.16 ELR20569.1 - 2 8.8 7.4 4.6 7.6 4.0 2.6 2 0 0 2 2 2 0 Divalent cation transporter ChuX_HutX PF06228.13 ELR20570.1 - 0.03 14.1 0.1 0.073 12.9 0.0 1.6 2 0 0 2 2 2 0 Haem utilisation ChuX/HutX MMADHC PF10229.9 ELR20570.1 - 0.031 14.0 0.7 0.054 13.2 0.7 1.3 1 0 0 1 1 1 0 Methylmalonic aciduria and homocystinuria type D protein Borrelia_P83 PF05262.11 ELR20570.1 - 0.06 11.8 10.8 0.072 11.6 10.8 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein DUF5300 PF17224.3 ELR20571.1 - 0.015 15.6 0.0 0.063 13.5 0.0 2.1 1 0 0 1 1 1 0 Domain of unknown function (DUF5300) CMS1 PF14617.6 ELR20572.1 - 7.4e-20 71.4 5.5 2.3e-19 69.7 0.1 2.1 2 0 0 2 2 2 2 U3-containing 90S pre-ribosomal complex subunit DEAD PF00270.29 ELR20572.1 - 9.5e-09 35.3 0.0 1e-08 35.2 0.0 1.2 1 0 0 1 1 1 1 DEAD/DEAH box helicase Peptidase_A3 PF02160.15 ELR20572.1 - 0.053 13.0 0.0 0.081 12.4 0.0 1.2 1 0 0 1 1 1 0 Cauliflower mosaic virus peptidase (A3) ETF_QO PF05187.13 ELR20573.1 - 1.3e-38 131.3 0.3 2.1e-38 130.6 0.3 1.3 1 0 0 1 1 1 1 Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S FAD_binding_2 PF00890.24 ELR20573.1 - 1.8e-08 33.9 1.6 1.2e-05 24.6 1.9 2.2 2 0 0 2 2 2 2 FAD binding domain DAO PF01266.24 ELR20573.1 - 1.1e-07 31.8 2.3 4.6e-05 23.2 1.1 2.3 1 1 0 2 2 2 2 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 ELR20573.1 - 1.6e-07 31.4 0.0 4.3e-07 30.1 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 ELR20573.1 - 2.1e-05 23.9 0.1 3e-05 23.4 0.1 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 ELR20573.1 - 7.7e-05 22.1 0.0 0.00046 19.5 0.1 1.9 2 0 0 2 2 2 1 Thi4 family FAD_binding_3 PF01494.19 ELR20573.1 - 0.00011 21.5 0.3 0.00021 20.7 0.3 1.4 1 0 0 1 1 1 1 FAD binding domain HI0933_like PF03486.14 ELR20573.1 - 0.00015 20.6 0.3 0.00044 19.1 0.6 1.6 2 0 0 2 2 2 1 HI0933-like protein Pyr_redox_3 PF13738.6 ELR20573.1 - 0.0002 20.7 0.7 0.00033 20.0 0.7 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 ELR20573.1 - 0.0003 19.9 0.1 0.00043 19.4 0.1 1.2 1 0 0 1 1 1 1 Lycopene cyclase protein Pyr_redox PF00070.27 ELR20573.1 - 0.00044 20.8 0.3 1.5 9.5 0.0 2.4 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 ELR20573.1 - 0.00065 19.7 0.2 0.0013 18.8 0.2 1.4 1 0 0 1 1 1 1 FAD-NAD(P)-binding K_oxygenase PF13434.6 ELR20573.1 - 0.02 14.1 0.0 0.029 13.5 0.0 1.2 1 0 0 1 1 1 0 L-lysine 6-monooxygenase (NADPH-requiring) FAD_oxidored PF12831.7 ELR20573.1 - 0.027 13.8 0.1 0.035 13.4 0.1 1.2 1 0 0 1 1 1 0 FAD dependent oxidoreductase Trp_halogenase PF04820.14 ELR20573.1 - 0.059 12.2 0.4 0.24 10.2 0.4 1.8 2 0 0 2 2 2 0 Tryptophan halogenase GIDA PF01134.22 ELR20573.1 - 0.12 11.4 0.1 0.18 10.8 0.1 1.2 1 0 0 1 1 1 0 Glucose inhibited division protein A HMG_box PF00505.19 ELR20574.1 - 5.3e-18 65.2 0.0 5.3e-18 65.2 0.0 3.2 3 1 0 3 3 3 1 HMG (high mobility group) box HMG_box_2 PF09011.10 ELR20574.1 - 1.9e-08 34.8 0.0 1.9e-08 34.8 0.0 3.4 4 2 0 4 4 4 1 HMG-box domain Unstab_antitox PF09720.10 ELR20574.1 - 6.4 6.9 6.8 47 4.1 0.1 3.4 3 0 0 3 3 3 0 Putative addiction module component SAM_1 PF00536.30 ELR20576.1 - 3.4e-15 56.2 0.0 6.1e-15 55.4 0.0 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 ELR20576.1 - 4.7e-11 42.6 0.0 8.5e-11 41.8 0.0 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) ubiquitin PF00240.23 ELR20577.1 - 2e-17 62.7 0.0 2.9e-17 62.2 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin family UQ_con PF00179.26 ELR20577.1 - 2.9e-05 23.7 0.0 4.8e-05 23.0 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Rad60-SLD PF11976.8 ELR20577.1 - 0.00012 21.8 0.0 0.00019 21.2 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.9 ELR20577.1 - 0.022 15.3 0.0 0.055 14.0 0.0 1.6 1 0 0 1 1 1 0 DUF2407 ubiquitin-like domain Ubiquitin_4 PF18036.1 ELR20577.1 - 0.066 13.3 0.0 0.88 9.7 0.2 2.1 1 1 1 2 2 2 0 Ubiquitin-like domain Ubiquitin_2 PF14560.6 ELR20577.1 - 0.12 12.9 0.0 0.38 11.2 0.0 1.7 1 1 0 1 1 1 0 Ubiquitin-like domain RhoGAP PF00620.27 ELR20578.1 - 2.3e-17 63.2 0.1 4.7e-17 62.2 0.1 1.5 1 0 0 1 1 1 1 RhoGAP domain VWA_2 PF13519.6 ELR20578.1 - 1.5e-05 25.6 0.0 4.6e-05 24.0 0.0 1.9 1 1 0 1 1 1 1 von Willebrand factor type A domain Ofd1_CTDD PF10637.9 ELR20578.1 - 0.018 14.4 0.7 0.033 13.6 0.7 1.4 1 0 0 1 1 1 0 Oxoglutarate and iron-dependent oxygenase degradation C-term PAP2 PF01569.21 ELR20579.1 - 1.7e-19 70.0 6.7 2.7e-19 69.3 6.7 1.4 1 0 0 1 1 1 1 PAP2 superfamily PAP2_3 PF14378.6 ELR20579.1 - 3.4e-08 33.4 4.4 5.2e-08 32.8 4.4 1.3 1 0 0 1 1 1 1 PAP2 superfamily PAP2_C PF14360.6 ELR20579.1 - 0.69 10.5 3.5 0.23 12.0 0.4 1.7 2 0 0 2 2 2 0 PAP2 superfamily C-terminal Peptidase_C101 PF16218.5 ELR20580.1 - 0.17 11.1 0.0 0.4 9.9 0.0 1.6 1 0 0 1 1 1 0 Peptidase family C101 HEAT PF02985.22 ELR20580.1 - 7.6 7.1 12.0 7.1 7.2 0.0 5.2 5 0 0 5 5 5 0 HEAT repeat dCMP_cyt_deam_1 PF00383.23 ELR20581.1 - 5.6e-15 55.1 0.1 6.7e-09 35.6 0.0 3.3 3 0 0 3 3 3 2 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 ELR20581.1 - 2.5e-05 24.0 0.3 0.17 11.7 0.0 2.7 3 0 0 3 3 3 2 MafB19-like deaminase OTT_1508_deam PF14441.6 ELR20581.1 - 0.028 14.4 1.9 0.52 10.3 0.1 2.6 2 0 0 2 2 2 0 OTT_1508-like deaminase SNAD4 PF18750.1 ELR20581.1 - 0.062 13.4 0.2 1 9.5 0.0 2.3 2 0 0 2 2 2 0 Secreted Novel AID/APOBEC-like Deaminase 4 Bd3614-deam PF14439.6 ELR20581.1 - 3.5 7.7 4.7 7.1 6.7 0.1 3.1 2 1 1 3 3 3 0 Bd3614-like deaminase PIF1 PF05970.14 ELR20582.1 - 1.4e-50 172.5 0.9 3.1e-49 168.1 0.9 2.5 1 1 0 1 1 1 1 PIF1-like helicase AAA_30 PF13604.6 ELR20582.1 - 4.1e-17 62.5 0.0 8.2e-17 61.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 ELR20582.1 - 1.2e-08 35.4 0.0 3.2e-08 34.0 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 ELR20582.1 - 9.6e-07 29.2 0.0 2.4e-06 27.9 0.0 1.6 1 0 0 1 1 1 1 AAA domain zf-CCHC PF00098.23 ELR20582.1 - 2.1e-05 24.4 2.6 2.1e-05 24.4 2.6 1.7 2 0 0 2 2 1 1 Zinc knuckle Herpes_Helicase PF02689.14 ELR20582.1 - 2.4e-05 22.5 0.0 0.00043 18.4 0.0 2.1 2 0 0 2 2 2 1 Helicase Mg_chelatase PF01078.21 ELR20582.1 - 0.00062 19.2 0.5 0.0016 17.8 0.1 1.8 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI UvrD_C_2 PF13538.6 ELR20582.1 - 0.00084 19.1 0.0 0.002 17.9 0.0 1.6 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain AAA_16 PF13191.6 ELR20582.1 - 0.009 16.4 0.1 0.02 15.3 0.1 1.5 1 0 0 1 1 1 1 AAA ATPase domain AAA_5 PF07728.14 ELR20582.1 - 0.012 15.6 0.1 0.031 14.3 0.0 1.7 2 0 0 2 2 1 0 AAA domain (dynein-related subfamily) DUF2075 PF09848.9 ELR20582.1 - 0.021 14.1 0.1 0.87 8.8 0.0 2.3 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) zf-CCHC_3 PF13917.6 ELR20582.1 - 0.034 14.1 0.2 0.068 13.2 0.2 1.4 1 0 0 1 1 1 0 Zinc knuckle AAA PF00004.29 ELR20582.1 - 0.037 14.5 0.0 0.074 13.5 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) DUF2122 PF09895.9 ELR20582.1 - 0.15 12.4 0.0 0.32 11.4 0.0 1.5 1 0 0 1 1 1 0 RecB-family nuclease (DUF2122) DUF3439 PF11921.8 ELR20582.1 - 0.32 11.0 12.1 0.81 9.7 12.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) zf-CCHC_2 PF13696.6 ELR20582.1 - 0.36 10.7 1.7 0.75 9.7 1.7 1.5 1 0 0 1 1 1 0 Zinc knuckle DUF2057 PF09829.9 ELR20582.1 - 0.39 10.9 2.9 1.5 9.0 0.0 2.2 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2057) SSP160 PF06933.11 ELR20582.1 - 1.1 7.3 13.4 1.7 6.7 13.4 1.2 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 zf-CCHC_5 PF14787.6 ELR20582.1 - 1.3 8.8 5.1 0.45 10.3 1.9 1.9 2 0 0 2 2 1 0 GAG-polyprotein viral zinc-finger Response_reg PF00072.24 ELR20583.1 - 2.5e-27 95.3 0.5 5.1e-27 94.3 0.5 1.6 1 0 0 1 1 1 1 Response regulator receiver domain HATPase_c PF02518.26 ELR20583.1 - 1.4e-25 90.0 0.0 2.3e-25 89.3 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase MEDS PF14417.6 ELR20583.1 - 3e-24 85.7 1.0 1e-23 83.9 0.0 2.4 2 0 0 2 2 2 1 MEDS: MEthanogen/methylotroph, DcmR Sensory domain HisKA PF00512.25 ELR20583.1 - 2.1e-18 66.1 0.2 2.1e-18 66.1 0.2 2.9 3 0 0 3 3 3 1 His Kinase A (phospho-acceptor) domain HATPase_c_3 PF13589.6 ELR20583.1 - 0.0045 16.8 0.0 0.0094 15.8 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Cons_hypoth95 PF03602.15 ELR20583.1 - 0.0066 16.1 0.1 0.014 15.1 0.1 1.5 1 0 0 1 1 1 1 Conserved hypothetical protein 95 FleQ PF06490.11 ELR20583.1 - 0.075 13.4 0.1 0.25 11.7 0.1 1.9 1 0 0 1 1 1 0 Flagellar regulatory protein FleQ PBP1_TM PF14812.6 ELR20583.1 - 0.17 12.2 1.2 0.38 11.1 1.2 1.5 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal zf-C3HC4_3 PF13920.6 ELR20584.1 - 7.8e-14 51.3 11.9 1.3e-13 50.6 11.9 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 ELR20584.1 - 4.6e-06 26.4 11.5 4.6e-06 26.4 11.5 1.7 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 ELR20584.1 - 0.00045 20.1 12.6 0.001 19.0 12.6 1.6 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4 PF00097.25 ELR20584.1 - 0.0033 17.3 10.2 0.035 14.0 10.2 2.3 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 ELR20584.1 - 0.0034 17.7 14.2 0.0075 16.6 14.2 1.6 1 0 0 1 1 1 1 Ring finger domain K-box PF01486.17 ELR20584.1 - 0.059 13.6 2.0 0.1 12.7 2.0 1.5 1 0 0 1 1 1 0 K-box region zf-C3HC4_2 PF13923.6 ELR20584.1 - 0.11 12.4 15.9 0.14 12.1 14.9 1.7 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) UQ_con PF00179.26 ELR20585.1 - 1.6e-16 60.2 0.0 2.8e-16 59.4 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme ubiquitin PF00240.23 ELR20585.1 - 1.7e-05 24.5 0.0 3.4e-05 23.5 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin family RWD PF05773.22 ELR20585.1 - 0.14 12.4 0.1 0.24 11.7 0.1 1.3 1 0 0 1 1 1 0 RWD domain F-box-like PF12937.7 ELR20586.1 - 1.3e-08 34.6 0.0 2.7e-08 33.6 0.0 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ELR20586.1 - 3.1e-05 23.7 0.0 5.5e-05 22.9 0.0 1.4 1 0 0 1 1 1 1 F-box domain DUF1644 PF07800.12 ELR20586.1 - 0.04 14.0 1.2 0.2 11.7 1.2 2.2 1 1 0 1 1 1 0 Protein of unknown function (DUF1644) XPA_C PF05181.12 ELR20586.1 - 0.045 13.7 0.1 0.17 11.9 0.0 1.9 2 0 0 2 2 2 0 XPA protein C-terminus F-box_4 PF15966.5 ELR20586.1 - 0.07 13.0 0.0 0.16 11.9 0.0 1.6 1 0 0 1 1 1 0 F-box HEAT_EZ PF13513.6 ELR20587.1 - 1.2e-23 83.1 9.7 7.9e-11 42.2 0.0 9.0 9 1 2 11 11 10 4 HEAT-like repeat HEAT PF02985.22 ELR20587.1 - 1.8e-16 58.8 6.8 0.34 11.3 0.0 11.0 12 0 0 12 12 10 3 HEAT repeat HEAT_2 PF13646.6 ELR20587.1 - 1.1e-14 54.6 0.0 0.00075 19.8 0.0 7.1 4 3 3 7 7 7 4 HEAT repeats IBN_N PF03810.19 ELR20587.1 - 3.3e-14 52.5 3.0 4.1e-14 52.3 0.1 2.8 3 0 0 3 3 3 1 Importin-beta N-terminal domain Vac14_Fab1_bd PF12755.7 ELR20587.1 - 3.7e-09 37.0 0.1 8.8 7.0 0.0 7.3 4 2 4 9 9 9 2 Vacuolar 14 Fab1-binding region Arm PF00514.23 ELR20587.1 - 1.6e-08 34.2 9.5 0.18 11.9 0.0 6.7 7 0 0 7 7 7 3 Armadillo/beta-catenin-like repeat Cnd1 PF12717.7 ELR20587.1 - 3e-07 30.6 1.0 0.074 13.1 0.1 5.2 3 2 1 5 5 5 1 non-SMC mitotic condensation complex subunit 1 Adaptin_N PF01602.20 ELR20587.1 - 3.1e-07 29.3 2.5 0.032 12.8 0.1 5.1 3 2 1 5 5 5 1 Adaptin N terminal region DUF3437 PF11919.8 ELR20587.1 - 4.3e-06 26.6 2.3 0.2 11.6 0.1 4.3 5 0 0 5 5 5 2 Domain of unknown function (DUF3437) DUF3385 PF11865.8 ELR20587.1 - 6.1e-05 23.0 2.8 2.3 8.1 0.0 6.1 5 2 0 5 5 5 1 Domain of unknown function (DUF3385) UME PF08064.13 ELR20587.1 - 0.00019 21.3 3.7 0.076 12.9 0.0 4.8 6 0 0 6 6 6 1 UME (NUC010) domain Dopey_N PF04118.14 ELR20587.1 - 0.03 13.4 0.3 0.71 8.9 0.0 2.7 2 1 1 3 3 3 0 Dopey, N-terminal TetR_C_37 PF18665.1 ELR20587.1 - 0.035 14.7 0.2 0.11 13.1 0.2 1.8 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain TAF6_C PF07571.13 ELR20587.1 - 0.063 13.6 0.0 19 5.6 0.0 3.8 3 0 0 3 3 3 0 TAF6 C-terminal HEAT repeat domain UNC45-central PF11701.8 ELR20587.1 - 0.12 12.3 0.1 0.75 9.7 0.0 2.3 2 0 0 2 2 2 0 Myosin-binding striated muscle assembly central Polysacc_synt_3 PF13440.6 ELR20587.1 - 0.13 11.4 0.0 0.22 10.7 0.0 1.3 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein HEAT_PBS PF03130.16 ELR20587.1 - 0.96 10.3 3.6 78 4.4 0.2 4.4 4 0 0 4 4 3 0 PBS lyase HEAT-like repeat Methyltransf_24 PF13578.6 ELR20588.1 - 5.8e-16 59.4 0.0 9.3e-16 58.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_3 PF01596.17 ELR20588.1 - 1.4e-12 47.3 0.0 1.7e-12 47.0 0.0 1.1 1 0 0 1 1 1 1 O-methyltransferase Methyltransf_25 PF13649.6 ELR20588.1 - 3.3e-05 24.5 0.0 7.3e-05 23.4 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ELR20588.1 - 8.1e-05 22.5 0.0 0.00011 22.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain GCD14 PF08704.10 ELR20588.1 - 0.00088 19.0 0.0 0.0013 18.5 0.0 1.1 1 0 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit Methyltransf_18 PF12847.7 ELR20588.1 - 0.0015 18.5 0.0 0.0028 17.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 ELR20588.1 - 0.0057 16.4 0.0 0.0063 16.3 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Secretin_N PF03958.17 ELR20588.1 - 0.017 15.5 0.0 0.04 14.3 0.0 1.6 1 0 0 1 1 1 0 Bacterial type II/III secretion system short domain CmcI PF04989.12 ELR20588.1 - 0.031 14.0 0.0 0.046 13.4 0.0 1.2 1 0 0 1 1 1 0 Cephalosporin hydroxylase UPF0020 PF01170.18 ELR20588.1 - 0.04 13.6 0.0 0.089 12.5 0.0 1.7 1 1 0 1 1 1 0 Putative RNA methylase family UPF0020 TrmK PF04816.12 ELR20588.1 - 0.057 12.9 0.0 0.082 12.4 0.0 1.2 1 0 0 1 1 1 0 tRNA (adenine(22)-N(1))-methyltransferase vATP-synt_E PF01991.18 ELR20588.1 - 0.11 11.8 0.1 0.17 11.3 0.1 1.2 1 0 0 1 1 1 0 ATP synthase (E/31 kDa) subunit RhoGAP PF00620.27 ELR20589.1 - 1e-17 64.4 0.0 1.3e-12 47.8 0.0 2.4 1 1 1 2 2 2 2 RhoGAP domain SH3_2 PF07653.17 ELR20589.1 - 0.0016 18.1 0.0 0.0032 17.1 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain RNA_polI_A34 PF08208.11 ELR20589.1 - 2.3 8.3 34.7 1.4 8.9 7.5 2.6 3 0 0 3 3 3 0 DNA-directed RNA polymerase I subunit RPA34.5 RR_TM4-6 PF06459.12 ELR20589.1 - 2.8 7.7 15.8 0.53 10.1 2.9 2.6 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 DUF2052 PF09747.9 ELR20589.1 - 9.1 6.4 17.7 7.2 6.7 9.2 2.4 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) F-box-like PF12937.7 ELR20590.1 - 0.056 13.4 0.1 0.14 12.1 0.1 1.6 1 0 0 1 1 1 0 F-box-like Ald_Xan_dh_C2 PF02738.18 ELR20591.1 - 1.3e-162 542.1 0.0 2e-162 541.5 0.0 1.2 1 0 0 1 1 1 1 Molybdopterin-binding domain of aldehyde dehydrogenase FAD_binding_5 PF00941.21 ELR20591.1 - 1e-27 96.9 0.0 2.4e-27 95.8 0.0 1.6 1 0 0 1 1 1 1 FAD binding domain in molybdopterin dehydrogenase Ald_Xan_dh_C PF01315.22 ELR20591.1 - 1.1e-27 96.6 0.2 2.1e-27 95.7 0.2 1.5 1 0 0 1 1 1 1 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain Fer2_2 PF01799.20 ELR20591.1 - 1.7e-27 95.2 0.0 5.1e-27 93.7 0.0 1.9 1 0 0 1 1 1 1 [2Fe-2S] binding domain CO_deh_flav_C PF03450.17 ELR20591.1 - 3.9e-23 81.6 0.0 2.2e-22 79.2 0.0 2.4 2 0 0 2 2 2 1 CO dehydrogenase flavoprotein C-terminal domain Fer2 PF00111.27 ELR20591.1 - 1.2e-07 31.5 1.9 1.7e-06 27.9 0.1 2.7 2 0 0 2 2 2 1 2Fe-2S iron-sulfur cluster binding domain zf-C2H2_jaz PF12171.8 ELR20591.1 - 0.42 10.9 1.5 9 6.7 0.1 2.5 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding Glyco_hydro_79C PF16862.5 ELR20592.1 - 0.00084 20.2 0.1 0.0022 18.8 0.1 1.7 1 0 0 1 1 1 1 Glycosyl hydrolase family 79 C-terminal beta domain Metallophos PF00149.28 ELR20593.1 - 1.5e-09 38.7 2.0 2e-09 38.2 2.0 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 ELR20593.1 - 3.5e-09 37.1 0.0 1e-08 35.5 0.0 1.7 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Metallophos_3 PF14582.6 ELR20593.1 - 0.0048 16.2 0.0 0.0079 15.6 0.0 1.2 1 0 0 1 1 1 1 Metallophosphoesterase, calcineurin superfamily TFIIA PF03153.13 ELR20594.1 - 0.02 14.9 16.2 0.032 14.2 16.2 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Sclerostin PF05463.11 ELR20594.1 - 0.051 13.3 4.4 0.13 11.9 4.4 1.7 1 0 0 1 1 1 0 Sclerostin (SOST) RlaP PF10127.9 ELR20594.1 - 0.094 12.3 9.1 0.19 11.3 2.5 3.0 1 1 0 2 2 2 0 RNA repair pathway DNA polymerase beta family Caldesmon PF02029.15 ELR20594.1 - 2.8 6.6 39.2 0.031 13.0 31.0 1.8 2 0 0 2 2 2 0 Caldesmon Med5 PF08689.10 ELR20594.1 - 4.5 4.9 5.4 7.6 4.2 5.4 1.2 1 0 0 1 1 1 0 Mediator complex subunit Med5 Med26_M PF15694.5 ELR20595.1 - 0.00093 19.3 2.7 0.0011 19.1 2.7 1.2 1 0 0 1 1 1 1 Mediator complex subunit 26 middle domain eIF3_subunit PF08597.10 ELR20595.1 - 0.061 13.2 6.0 0.068 13.1 6.0 1.0 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit Caldesmon PF02029.15 ELR20596.1 - 0.039 12.7 19.7 0.057 12.2 19.7 1.2 1 0 0 1 1 1 0 Caldesmon Asp-B-Hydro_N PF05279.11 ELR20596.1 - 0.36 10.8 10.0 0.45 10.6 10.0 1.1 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region Presenilin PF01080.17 ELR20596.1 - 0.58 8.9 9.0 0.66 8.7 9.0 1.1 1 0 0 1 1 1 0 Presenilin DUF4551 PF15087.6 ELR20596.1 - 0.68 8.7 10.0 0.8 8.5 10.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) GREB1 PF15782.5 ELR20596.1 - 0.81 6.7 4.9 0.92 6.5 4.9 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Paramyxo_ncap PF00973.19 ELR20596.1 - 1.2 8.0 10.1 1.5 7.6 10.1 1.1 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein Neur_chan_memb PF02932.16 ELR20596.1 - 1.6 8.7 4.8 1.8 8.6 4.8 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region SLC12 PF03522.15 ELR20596.1 - 2 7.4 8.6 2.3 7.1 8.6 1.0 1 0 0 1 1 1 0 Solute carrier family 12 Med5 PF08689.10 ELR20596.1 - 2.1 6.0 4.5 2.6 5.7 4.5 1.0 1 0 0 1 1 1 0 Mediator complex subunit Med5 Ndc1_Nup PF09531.10 ELR20596.1 - 3 6.4 5.8 3.3 6.3 5.8 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Hid1 PF12722.7 ELR20596.1 - 4.7 5.2 9.9 5.5 5.0 9.9 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Sin_N PF04801.13 ELR20596.1 - 5.2 6.2 15.0 7.1 5.7 15.0 1.1 1 0 0 1 1 1 0 Sin-like protein conserved region Hydin_ADK PF17213.3 ELR20596.1 - 9.6 6.4 9.4 13 6.0 9.4 1.1 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain zf-MYND PF01753.18 ELR20597.1 - 6.1e-09 35.8 12.4 1.2e-08 34.9 12.4 1.5 1 1 0 1 1 1 1 MYND finger Adaptin_N PF01602.20 ELR20598.1 - 2e-08 33.3 0.3 1.8e-05 23.5 0.2 4.0 2 2 1 3 3 3 1 Adaptin N terminal region HEAT_2 PF13646.6 ELR20598.1 - 7.7e-05 23.0 14.9 0.00057 20.2 0.1 6.4 5 2 0 5 5 5 1 HEAT repeats Cnd1 PF12717.7 ELR20598.1 - 0.00031 20.8 3.8 0.23 11.5 0.1 4.6 3 2 0 4 4 4 1 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.22 ELR20598.1 - 0.0051 17.0 3.8 3.2 8.3 0.3 6.0 7 0 0 7 7 7 1 HEAT repeat Cohesin_HEAT PF12765.7 ELR20598.1 - 0.017 15.4 1.0 2.1 8.7 0.0 3.9 4 0 0 4 4 4 0 HEAT repeat associated with sister chromatid cohesion MA3 PF02847.17 ELR20598.1 - 0.024 14.6 0.3 7.9 6.5 0.0 3.0 2 0 0 2 2 2 0 MA3 domain FANCI_S2 PF14676.6 ELR20598.1 - 0.057 13.7 1.0 7 6.9 0.1 3.1 2 1 1 3 3 3 0 FANCI solenoid 2 Peptidase_C50 PF03568.17 ELR20599.1 - 1.3e-61 208.9 0.0 2.2e-61 208.2 0.0 1.4 1 0 0 1 1 1 1 Peptidase family C50 TPR_8 PF13181.6 ELR20599.1 - 0.014 15.6 5.1 14 6.2 0.2 5.5 4 0 0 4 4 4 0 Tetratricopeptide repeat RNA_pol_Rpc4 PF05132.14 ELR20599.1 - 8.3 6.8 7.2 4.2 7.8 0.5 3.5 3 0 0 3 3 3 0 RNA polymerase III RPC4 Branch PF02485.21 ELR20600.1 - 9.7e-17 61.3 0.0 1e-14 54.6 0.0 2.2 1 1 1 2 2 2 2 Core-2/I-Branching enzyme PGK PF00162.19 ELR20601.1 - 6.5e-148 492.7 0.0 7.4e-148 492.5 0.0 1.0 1 0 0 1 1 1 1 Phosphoglycerate kinase PTEN_C2 PF10409.9 ELR20602.1 - 1e-17 64.2 0.0 1.9e-17 63.3 0.0 1.5 1 0 0 1 1 1 1 C2 domain of PTEN tumour-suppressor protein DSPc PF00782.20 ELR20602.1 - 2.1e-05 24.4 0.1 4.2e-05 23.4 0.1 1.4 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.6 ELR20602.1 - 0.00041 20.5 0.0 0.0009 19.4 0.0 1.6 1 0 0 1 1 1 1 Inositol hexakisphosphate PBP1_TM PF14812.6 ELR20602.1 - 0.00062 20.1 1.3 0.0026 18.1 1.3 2.1 1 0 0 1 1 1 1 Transmembrane domain of transglycosylase PBP1 at N-terminal Y_phosphatase PF00102.27 ELR20602.1 - 0.0014 18.3 0.0 0.0023 17.5 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.6 ELR20602.1 - 0.013 15.4 0.0 0.029 14.4 0.0 1.5 1 0 0 1 1 1 0 Tyrosine phosphatase family FAM176 PF14851.6 ELR20602.1 - 0.025 14.2 0.3 0.05 13.3 0.3 1.4 1 0 0 1 1 1 0 FAM176 family CENP-B_dimeris PF09026.10 ELR20602.1 - 0.049 14.0 1.7 0.12 12.7 1.7 1.6 1 0 0 1 1 1 0 Centromere protein B dimerisation domain DUF4366 PF14283.6 ELR20602.1 - 0.11 12.5 0.1 2.9 7.9 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4366) Cullin_binding PF03556.15 ELR20603.1 - 5.9e-28 97.7 0.6 8.9e-28 97.1 0.6 1.3 1 0 0 1 1 1 1 Cullin binding Ppx-GppA PF02541.16 ELR20603.1 - 0.18 11.2 0.0 0.24 10.8 0.0 1.2 1 0 0 1 1 1 0 Ppx/GppA phosphatase family NUDIX PF00293.28 ELR20604.1 - 3.3e-07 30.4 0.7 9.9e-07 28.9 0.7 1.8 1 1 0 1 1 1 1 NUDIX domain DCP2 PF05026.13 ELR20604.1 - 1.8e-05 25.0 0.5 4.2e-05 23.8 0.5 1.6 1 0 0 1 1 1 1 Dcp2, box A domain MIF4G PF02854.19 ELR20605.1 - 2.4e-50 171.1 4.4 8.8e-50 169.3 0.9 2.6 2 0 0 2 2 2 1 MIF4G domain MA3 PF02847.17 ELR20605.1 - 8.1e-21 74.1 0.8 6.5e-20 71.2 0.1 2.6 3 0 0 3 3 3 1 MA3 domain W2 PF02020.18 ELR20605.1 - 1.9e-13 50.3 5.2 4.5e-13 49.1 2.1 3.0 3 0 0 3 3 3 1 eIF4-gamma/eIF5/eIF2-epsilon eIF_4G1 PF12152.8 ELR20605.1 - 0.0011 19.1 0.0 0.003 17.7 0.0 1.8 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 4G1 CLASP_N PF12348.8 ELR20605.1 - 0.0024 17.5 0.0 1.5 8.3 0.0 2.4 2 0 0 2 2 2 2 CLASP N terminal ATP-synt_C PF00137.21 ELR20606.1 - 6e-36 122.6 36.2 2.4e-22 79.0 13.4 2.2 2 0 0 2 2 2 2 ATP synthase subunit C PIRT PF15099.6 ELR20606.1 - 2.2 7.8 3.9 1.1 8.9 1.3 1.7 1 1 0 2 2 2 0 Phosphoinositide-interacting protein family Peptidase_S9_N PF02897.15 ELR20607.1 - 1.1e-125 419.7 0.2 1.6e-125 419.2 0.2 1.1 1 0 0 1 1 1 1 Prolyl oligopeptidase, N-terminal beta-propeller domain Peptidase_S9 PF00326.21 ELR20607.1 - 4.4e-68 228.9 0.0 6.6e-68 228.3 0.0 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family Esterase PF00756.20 ELR20607.1 - 0.0046 16.6 0.0 0.0081 15.8 0.0 1.3 1 0 0 1 1 1 1 Putative esterase Abhydrolase_3 PF07859.13 ELR20607.1 - 0.017 15.0 0.0 0.03 14.2 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold AXE1 PF05448.12 ELR20607.1 - 0.083 11.6 0.0 0.14 10.8 0.0 1.3 1 0 0 1 1 1 0 Acetyl xylan esterase (AXE1) Pkinase_Tyr PF07714.17 ELR20608.1 - 9e-122 405.3 0.0 1.6e-61 207.8 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 ELR20608.1 - 4.1e-106 354.2 0.0 9.4e-54 182.5 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain PBP_like_2 PF12849.7 ELR20608.1 - 2.2e-40 139.1 23.6 3.2e-26 92.6 1.6 2.5 3 0 0 3 3 2 2 PBP superfamily domain Guanylate_cyc PF00211.20 ELR20608.1 - 5.2e-11 42.5 0.0 9.2e-11 41.7 0.0 1.3 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain APH PF01636.23 ELR20608.1 - 4.5e-07 30.0 0.1 0.0003 20.8 0.0 2.8 2 0 0 2 2 2 2 Phosphotransferase enzyme family Haspin_kinase PF12330.8 ELR20608.1 - 0.0007 18.6 0.0 0.037 13.0 0.0 2.3 2 0 0 2 2 2 1 Haspin like kinase domain EGF_2 PF07974.13 ELR20608.1 - 0.0025 18.2 12.5 0.0048 17.2 12.5 1.5 1 0 0 1 1 1 1 EGF-like domain Kinase-like PF14531.6 ELR20608.1 - 0.0045 16.3 0.0 0.83 8.9 0.0 2.3 2 0 0 2 2 2 1 Kinase-like PBP_like PF12727.7 ELR20608.1 - 0.0053 15.9 0.0 2.2 7.4 0.0 2.5 2 0 0 2 2 2 2 PBP superfamily domain RIO1 PF01163.22 ELR20608.1 - 0.014 15.0 0.4 1.3 8.6 0.1 2.4 2 0 0 2 2 2 0 RIO1 family FTA2 PF13095.6 ELR20608.1 - 0.016 14.9 0.1 0.29 10.7 0.0 2.8 2 2 2 4 4 4 0 Kinetochore Sim4 complex subunit FTA2 Kdo PF06293.14 ELR20608.1 - 0.032 13.6 0.1 4.3 6.6 0.0 2.3 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family Metallothio_6 PF05522.11 ELR20608.1 - 0.19 12.2 8.5 0.39 11.2 8.5 1.5 1 0 0 1 1 1 0 Metallothionein TMEM154 PF15102.6 ELR20608.1 - 0.54 10.2 9.9 0.56 10.1 0.0 2.5 2 0 0 2 2 2 0 TMEM154 protein family Actin PF00022.19 ELR20609.1 - 9.4e-40 136.4 0.0 1.6e-38 132.4 0.0 2.0 1 1 0 1 1 1 1 Actin MatP_C PF17414.2 ELR20609.1 - 0.14 12.4 0.2 1.4 9.2 0.1 2.4 2 0 0 2 2 2 0 MatP C-terminal ribbon-helix-helix domain DLIC PF05783.11 ELR20611.1 - 3.7e-79 266.7 18.5 1.6e-49 169.1 0.2 3.0 1 1 2 3 3 3 3 Dynein light intermediate chain (DLIC) Roc PF08477.13 ELR20611.1 - 0.00036 20.7 0.0 0.00086 19.5 0.0 1.7 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase CHAD PF05235.14 ELR20611.1 - 0.061 13.3 0.0 0.16 12.0 0.0 1.8 1 0 0 1 1 1 0 CHAD domain MMR_HSR1 PF01926.23 ELR20611.1 - 0.063 13.4 0.1 0.21 11.6 0.0 2.0 2 0 0 2 2 2 0 50S ribosome-binding GTPase Ras PF00071.22 ELR20611.1 - 0.067 12.8 0.0 0.22 11.1 0.0 1.7 1 1 0 1 1 1 0 Ras family Arf PF00025.21 ELR20611.1 - 0.15 11.5 0.2 11 5.4 0.0 2.6 2 1 1 3 3 3 0 ADP-ribosylation factor family K_channel_TID PF07941.11 ELR20611.1 - 7.2 7.1 8.9 0.37 11.3 2.4 2.1 2 0 0 2 2 2 0 Potassium channel Kv1.4 tandem inactivation domain Histone PF00125.24 ELR20612.1 - 1e-40 139.1 3.1 1.8e-40 138.3 3.1 1.5 1 1 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-T_C PF15511.6 ELR20612.1 - 0.0025 17.9 0.0 0.004 17.3 0.0 1.3 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold CBFD_NFYB_HMF PF00808.23 ELR20612.1 - 0.0033 17.7 0.7 0.0098 16.2 0.7 1.8 1 1 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID-31kDa PF02291.15 ELR20612.1 - 0.019 15.0 0.0 0.028 14.5 0.0 1.2 1 0 0 1 1 1 0 Transcription initiation factor IID, 31kD subunit CENP-S PF15630.6 ELR20612.1 - 0.11 12.9 0.0 0.16 12.4 0.0 1.3 1 0 0 1 1 1 0 CENP-S protein QWRF PF04484.12 ELR20612.1 - 0.49 10.1 7.9 0.59 9.8 7.9 1.1 1 0 0 1 1 1 0 QWRF family DUF4603 PF15376.6 ELR20612.1 - 1.5 6.1 5.2 1.9 5.8 5.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4603) TPPII_N PF12583.8 ELR20612.1 - 5.5 7.6 7.9 7.3 7.2 7.9 1.2 1 0 0 1 1 1 0 Tripeptidyl peptidase II N terminal zf-C3HC4_2 PF13923.6 ELR20613.1 - 3.6e-10 39.5 10.0 6.5e-10 38.7 10.0 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) RAWUL PF16207.5 ELR20613.1 - 6e-08 33.2 0.0 1.3e-07 32.2 0.0 1.5 1 0 0 1 1 1 1 RAWUL domain RING finger- and WD40-associated ubiquitin-like zf-C3HC4 PF00097.25 ELR20613.1 - 2e-07 30.8 9.4 3.3e-07 30.1 9.4 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 ELR20613.1 - 1.2e-06 28.7 7.7 1.9e-06 28.1 7.7 1.3 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_3 PF13920.6 ELR20613.1 - 2.1e-05 24.3 6.6 3.9e-05 23.4 6.6 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ELR20613.1 - 5.7e-05 23.0 8.4 9.5e-05 22.3 8.4 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 ELR20613.1 - 0.00082 19.3 9.0 0.0016 18.4 9.0 1.5 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_6 PF14835.6 ELR20613.1 - 0.00096 19.0 2.5 0.0016 18.3 2.5 1.3 1 0 0 1 1 1 1 zf-RING of BARD1-type protein Prok-RING_4 PF14447.6 ELR20613.1 - 0.0011 18.7 5.5 0.0023 17.8 5.5 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_10 PF16685.5 ELR20613.1 - 0.0042 17.2 3.6 0.0073 16.4 3.6 1.4 1 0 0 1 1 1 1 zinc RING finger of MSL2 zf-rbx1 PF12678.7 ELR20613.1 - 0.0089 16.3 5.8 0.017 15.4 5.8 1.5 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_4 PF15227.6 ELR20613.1 - 0.038 14.1 8.7 0.076 13.2 8.7 1.5 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING DUF1897 PF09005.10 ELR20613.1 - 0.042 13.3 0.2 0.11 11.9 0.2 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF1897) zf-Nse PF11789.8 ELR20613.1 - 0.088 12.6 3.7 0.081 12.8 2.3 1.7 2 0 0 2 2 2 0 Zinc-finger of the MIZ type in Nse subunit DUF1272 PF06906.11 ELR20613.1 - 0.14 12.2 5.0 0.28 11.3 5.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1272) zf-C3HC4_5 PF17121.5 ELR20613.1 - 0.15 12.0 3.8 0.19 11.6 2.7 1.7 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) DZR PF12773.7 ELR20613.1 - 0.21 11.6 3.7 0.35 10.9 3.7 1.3 1 0 0 1 1 1 0 Double zinc ribbon Zn_ribbon_17 PF17120.5 ELR20613.1 - 0.37 10.4 4.1 0.71 9.5 4.1 1.4 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type PAP2 PF01569.21 ELR20614.1 - 8.2e-12 45.1 2.6 8.2e-12 45.1 2.6 3.2 4 0 0 4 4 4 1 PAP2 superfamily DPM3 PF08285.11 ELR20614.1 - 5.1 7.4 6.1 1.8 8.8 0.3 3.1 2 1 2 4 4 4 0 Dolichol-phosphate mannosyltransferase subunit 3 (DPM3) DUF971 PF06155.12 ELR20615.1 - 1.1e-09 38.8 1.0 1.1e-08 35.6 1.0 2.2 1 1 0 1 1 1 1 Protein of unknown function (DUF971) Prefoldin PF02996.17 ELR20616.1 - 3.4e-20 72.1 0.5 4.7e-20 71.7 0.5 1.2 1 0 0 1 1 1 1 Prefoldin subunit MAAL_C PF07476.11 ELR20616.1 - 0.022 13.9 0.1 0.1 11.8 0.1 1.8 2 0 0 2 2 2 0 Methylaspartate ammonia-lyase C-terminus YojJ PF10372.9 ELR20616.1 - 0.15 12.1 1.9 0.37 10.9 0.7 2.0 2 0 0 2 2 2 0 Bacterial membrane-spanning protein N-terminus Arm-DNA-bind_3 PF13356.6 ELR20616.1 - 0.21 12.0 1.2 13 6.3 0.7 2.4 2 1 0 2 2 2 0 Arm DNA-binding domain START PF01852.19 ELR20617.1 - 3.6e-17 62.5 0.0 5.4e-17 61.9 0.0 1.2 1 0 0 1 1 1 1 START domain adh_short PF00106.25 ELR20618.1 - 0.0092 15.4 0.3 0.12 11.8 0.0 2.7 3 1 0 3 3 3 1 short chain dehydrogenase BMC PF00936.19 ELR20618.1 - 0.098 12.7 2.5 0.28 11.2 2.5 1.7 1 0 0 1 1 1 0 BMC domain APG6_N PF17675.1 ELR20619.1 - 0.037 14.6 9.7 0.064 13.8 9.7 1.4 1 0 0 1 1 1 0 Apg6 coiled-coil region VSG_B PF13206.6 ELR20619.1 - 0.066 12.5 9.3 0.09 12.0 9.3 1.2 1 0 0 1 1 1 0 Trypanosomal VSG domain Allexi_40kDa PF05549.11 ELR20619.1 - 0.07 12.6 0.4 0.099 12.1 0.4 1.2 1 0 0 1 1 1 0 Allexivirus 40kDa protein HSP70 PF00012.20 ELR20619.1 - 0.49 8.5 6.2 0.6 8.2 6.2 1.0 1 0 0 1 1 1 0 Hsp70 protein Tho2 PF11262.8 ELR20619.1 - 1.5 7.9 8.1 2.1 7.5 8.1 1.1 1 0 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 TMPIT PF07851.13 ELR20619.1 - 4.3 6.5 6.6 5.9 6.0 6.6 1.1 1 0 0 1 1 1 0 TMPIT-like protein DUF4407 PF14362.6 ELR20619.1 - 8.4 5.6 9.6 9.5 5.5 9.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DSBA PF01323.20 ELR20620.1 - 3.4e-20 72.7 0.0 1.2e-18 67.6 0.0 2.0 1 1 0 1 1 1 1 DSBA-like thioredoxin domain Thioredoxin_4 PF13462.6 ELR20620.1 - 0.0027 17.9 0.0 0.004 17.3 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin EF-hand_6 PF13405.6 ELR20621.1 - 4.8e-11 41.7 0.1 0.00041 20.1 0.0 3.3 3 1 0 3 3 3 2 EF-hand domain EF-hand_7 PF13499.6 ELR20621.1 - 1.7e-09 38.0 0.4 0.00027 21.3 0.1 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 ELR20621.1 - 9.2e-09 34.2 0.1 0.0095 15.4 0.0 3.2 4 0 0 4 4 4 2 EF hand EF-hand_8 PF13833.6 ELR20621.1 - 0.00024 20.9 0.3 0.062 13.2 0.1 3.0 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_9 PF14658.6 ELR20621.1 - 0.00096 19.4 0.0 0.093 13.1 0.0 2.3 2 0 0 2 2 2 1 EF-hand domain EF-hand_5 PF13202.6 ELR20621.1 - 0.17 11.4 0.2 8.8 6.0 0.0 2.7 3 0 0 3 3 3 0 EF hand Methyltransf_23 PF13489.6 ELR20622.1 - 3.4e-07 30.2 0.0 5.7e-07 29.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ELR20622.1 - 1e-05 25.4 0.0 2e-05 24.5 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ELR20622.1 - 7.2e-05 23.4 0.0 0.00012 22.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ELR20622.1 - 0.00013 22.6 0.0 0.00022 21.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ELR20622.1 - 0.00027 21.5 0.0 0.00044 20.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 ELR20622.1 - 0.0011 18.5 0.1 0.0056 16.3 0.1 1.9 1 1 0 1 1 1 1 Methyltransferase small domain Methyltransf_32 PF13679.6 ELR20622.1 - 0.0046 17.0 0.0 0.011 15.7 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain AdoMet_MTase PF07757.13 ELR20622.1 - 0.13 12.6 0.0 0.47 10.8 0.0 1.9 2 0 0 2 2 2 0 Predicted AdoMet-dependent methyltransferase SIKE PF05769.11 ELR20623.1 - 1.7e-15 57.4 17.2 3.4e-15 56.4 17.0 1.5 1 1 1 2 2 2 1 SIKE family Wtap PF17098.5 ELR20623.1 - 0.0066 16.4 3.2 0.0066 16.4 3.2 2.6 1 1 2 3 3 3 1 WTAP/Mum2p family 14-3-3 PF00244.20 ELR20623.1 - 0.0082 15.7 7.5 0.013 15.0 7.5 1.2 1 0 0 1 1 1 1 14-3-3 protein bZIP_1 PF00170.21 ELR20623.1 - 0.023 14.8 11.7 0.27 11.4 0.5 3.4 3 0 0 3 3 3 0 bZIP transcription factor FlaC_arch PF05377.11 ELR20623.1 - 0.025 14.9 6.7 0.27 11.6 0.3 2.8 3 0 0 3 3 3 0 Flagella accessory protein C (FlaC) GldM_N PF12081.8 ELR20623.1 - 0.05 13.7 6.7 0.07 13.2 6.7 1.2 1 0 0 1 1 1 0 GldM N-terminal domain Med28 PF11594.8 ELR20623.1 - 0.09 12.9 4.5 0.28 11.3 4.5 1.9 1 1 0 1 1 1 0 Mediator complex subunit 28 DUF2570 PF10828.8 ELR20623.1 - 0.14 12.0 9.9 18 5.2 0.0 3.0 1 1 0 2 2 2 0 Protein of unknown function (DUF2570) Cnn_1N PF07989.11 ELR20623.1 - 0.18 12.0 13.0 1.9 8.7 8.8 3.2 2 1 1 3 3 3 0 Centrosomin N-terminal motif 1 Mto2_bdg PF12808.7 ELR20623.1 - 0.33 11.3 0.2 0.33 11.3 0.2 3.4 3 1 0 3 3 3 0 Micro-tubular organiser Mto1 C-term Mto2-binding region DivIC PF04977.15 ELR20623.1 - 0.63 9.9 12.1 1.4 8.8 0.6 2.9 2 1 0 3 3 3 0 Septum formation initiator DUF262 PF03235.14 ELR20623.1 - 0.72 10.0 3.7 0.95 9.6 3.7 1.1 1 0 0 1 1 1 0 Protein of unknown function DUF262 FUSC PF04632.12 ELR20623.1 - 1.1 7.7 7.9 1.3 7.5 7.9 1.0 1 0 0 1 1 1 0 Fusaric acid resistance protein family FapA PF03961.13 ELR20623.1 - 1.5 7.4 6.6 1.6 7.2 6.6 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A bZIP_2 PF07716.15 ELR20623.1 - 1.7 8.8 11.2 7.2 6.8 4.0 3.2 3 1 0 3 3 3 0 Basic region leucine zipper YabA PF06156.13 ELR20623.1 - 1.8 9.3 16.0 5.8 7.6 5.1 2.7 1 1 1 2 2 2 0 Initiation control protein YabA ZapB PF06005.12 ELR20623.1 - 3.3 8.2 16.2 4.1e+02 1.5 16.2 2.8 1 1 0 1 1 1 0 Cell division protein ZapB LMBR1 PF04791.16 ELR20623.1 - 6.4 5.6 7.3 8.6 5.1 7.3 1.3 1 1 0 1 1 1 0 LMBR1-like membrane protein TRAM_LAG1_CLN8 PF03798.16 ELR20624.1 - 5.9e-30 104.5 25.8 9.6e-30 103.8 25.8 1.3 1 1 0 1 1 1 1 TLC domain EMC3_TMCO1 PF01956.16 ELR20624.1 - 0.017 14.9 5.3 1.1 9.0 0.0 2.7 2 1 0 2 2 2 0 Integral membrane protein EMC3/TMCO1-like ParA PF10609.9 ELR20625.1 - 2.6e-63 213.8 0.0 1.7e-48 165.3 0.0 2.0 1 1 1 2 2 2 2 NUBPL iron-transfer P-loop NTPase AAA_26 PF13500.6 ELR20625.1 - 0.1 12.4 0.0 0.85 9.4 0.0 2.0 1 1 0 1 1 1 0 AAA domain Lysine_decarbox PF03641.14 ELR20626.1 - 2.7e-40 137.5 0.1 3.7e-40 137.1 0.1 1.2 1 0 0 1 1 1 1 Possible lysine decarboxylase LDcluster4 PF18306.1 ELR20626.1 - 6.5e-12 45.3 0.1 9.1e-12 44.8 0.1 1.2 1 0 0 1 1 1 1 SLOG cluster4 family RTC PF01137.21 ELR20627.1 - 2.4e-59 200.2 0.0 2.7e-59 200.0 0.0 1.0 1 0 0 1 1 1 1 RNA 3'-terminal phosphate cyclase RTC_insert PF05189.13 ELR20627.1 - 3.1e-32 111.2 0.0 4.9e-32 110.5 0.0 1.3 1 0 0 1 1 1 1 RNA 3'-terminal phosphate cyclase (RTC), insert domain Atg14 PF10186.9 ELR20628.1 - 0.014 14.5 2.1 0.02 14.0 2.1 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 TALPID3 PF15324.6 ELR20628.1 - 0.03 12.0 5.7 0.046 11.4 5.7 1.1 1 0 0 1 1 1 0 Hedgehog signalling target Ctr PF04145.15 ELR20628.1 - 0.84 10.2 2.8 0.72 10.5 0.2 2.1 2 0 0 2 2 2 0 Ctr copper transporter family WD40 PF00400.32 ELR20629.1 - 8.8e-39 130.8 20.6 1.4e-07 32.1 0.8 7.5 6 1 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ELR20629.1 - 2.2e-12 47.1 5.0 0.031 14.6 0.0 5.9 3 1 1 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 ELR20629.1 - 1.9e-05 24.7 0.1 0.13 12.1 0.0 3.9 2 1 2 4 4 4 2 Eukaryotic translation initiation factor eIF2A IKI3 PF04762.12 ELR20629.1 - 0.032 12.3 8.1 0.75 7.7 0.2 3.0 2 1 1 3 3 3 0 IKI3 family Coatomer_WDAD PF04053.14 ELR20629.1 - 0.16 11.0 0.2 4.3 6.3 0.1 2.5 2 1 0 2 2 2 0 Coatomer WD associated region Spt5-NGN PF03439.13 ELR20630.1 - 2e-23 82.1 0.0 3.6e-23 81.3 0.0 1.4 1 0 0 1 1 1 1 Early transcription elongation factor of RNA pol II, NGN section KOW PF00467.29 ELR20630.1 - 5e-23 80.3 29.2 4.6e-08 32.7 0.3 7.4 7 0 0 7 7 7 5 KOW motif Spt5_N PF11942.8 ELR20630.1 - 0.0039 18.1 11.1 0.0039 18.1 11.1 3.4 3 0 0 3 3 3 1 Spt5 transcription elongation factor, acidic N-terminal DUF4438 PF14505.6 ELR20630.1 - 0.011 14.7 3.9 0.034 13.1 0.2 2.9 2 1 0 3 3 3 0 Domain of unknown function (DUF4438) RNase_P_Rpp14 PF01900.19 ELR20630.1 - 0.058 13.6 0.0 0.15 12.3 0.0 1.6 1 0 0 1 1 1 0 Rpp14/Pop5 family zf-AD PF07776.15 ELR20631.1 - 0.33 11.2 1.5 0.62 10.3 1.5 1.5 1 0 0 1 1 1 0 Zinc-finger associated domain (zf-AD) HSP90 PF00183.18 ELR20632.1 - 3.1e-97 326.6 0.0 2.8e-92 310.3 0.0 2.1 1 1 1 2 2 2 2 Hsp90 protein HATPase_c_3 PF13589.6 ELR20632.1 - 1.2e-12 47.8 0.1 3e-12 46.5 0.1 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 ELR20632.1 - 1.5e-07 31.9 0.1 2.9e-07 31.0 0.1 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DNA_pol3_a_NII PF11490.8 ELR20632.1 - 0.072 13.0 0.8 2 8.3 0.1 2.6 2 0 0 2 2 2 0 DNA polymerase III polC-type N-terminus II Pro_isomerase PF00160.21 ELR20633.1 - 7.7e-44 149.7 0.2 1.8e-43 148.5 0.1 1.7 2 0 0 2 2 2 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD WD40 PF00400.32 ELR20633.1 - 4.3e-14 52.7 0.1 1.9e-05 25.3 0.0 3.7 3 0 0 3 3 3 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ELR20633.1 - 0.00011 22.5 0.0 0.49 10.7 0.0 3.9 5 1 1 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ELR20633.1 - 0.00064 18.8 0.2 3.3 6.6 0.0 3.1 2 1 1 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein SNF2_N PF00176.23 ELR20634.1 - 1.3e-67 228.0 3.0 5.1e-67 226.1 2.9 1.9 1 1 0 1 1 1 1 SNF2 family N-terminal domain SLIDE PF09111.10 ELR20634.1 - 6.4e-40 135.7 0.1 6.4e-40 135.7 0.1 2.6 2 0 0 2 2 2 1 SLIDE HAND PF09110.11 ELR20634.1 - 7.2e-22 78.2 1.1 7.2e-22 78.2 1.1 4.1 3 1 0 3 3 2 1 HAND Helicase_C PF00271.31 ELR20634.1 - 1.5e-18 67.2 0.0 3e-17 63.0 0.0 2.9 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 ELR20634.1 - 1.1e-09 38.5 0.0 5.2e-09 36.3 0.0 2.3 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.29 ELR20634.1 - 3e-07 30.4 0.0 9.1e-07 28.8 0.0 1.8 1 0 0 1 1 1 1 DEAD/DEAH box helicase DBINO PF13892.6 ELR20634.1 - 0.00021 21.6 10.2 0.00021 21.6 10.2 4.1 4 1 1 5 5 4 1 DNA-binding domain HDA2-3 PF11496.8 ELR20634.1 - 0.00078 18.7 0.0 0.0028 16.9 0.0 2.1 1 0 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 GEMIN8 PF15348.6 ELR20634.1 - 0.0057 17.0 2.2 0.0057 17.0 2.2 3.6 3 1 1 4 4 4 1 Gemini of Cajal bodies-associated protein 8 AAA_22 PF13401.6 ELR20634.1 - 0.031 14.6 1.4 0.082 13.2 0.0 2.5 3 0 0 3 3 3 0 AAA domain AAA_14 PF13173.6 ELR20634.1 - 0.12 12.4 0.2 0.38 10.8 0.0 1.9 2 0 0 2 2 2 0 AAA domain Pkinase_Tyr PF07714.17 ELR20635.1 - 1.1e-60 205.2 0.0 1.5e-60 204.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ELR20635.1 - 2e-44 152.0 0.0 3.4e-44 151.2 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain TPR_1 PF00515.28 ELR20636.1 - 3.2e-14 52.1 9.0 0.033 14.0 0.0 5.6 5 0 0 5 5 5 5 Tetratricopeptide repeat TPR_2 PF07719.17 ELR20636.1 - 4.7e-12 45.1 13.8 0.03 14.4 0.1 5.7 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_14 PF13428.6 ELR20636.1 - 4.2e-10 39.6 11.7 0.052 14.4 0.5 6.8 4 1 2 6 6 6 4 Tetratricopeptide repeat TPR_16 PF13432.6 ELR20636.1 - 5.5e-08 33.3 7.7 0.24 12.1 0.0 5.2 5 0 0 5 5 4 2 Tetratricopeptide repeat TPR_11 PF13414.6 ELR20636.1 - 1.7e-07 30.8 4.2 0.033 13.9 0.2 4.7 4 0 0 4 4 4 2 TPR repeat TPR_17 PF13431.6 ELR20636.1 - 4.2e-07 29.9 4.8 0.0096 16.2 0.5 4.3 4 0 0 4 4 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 ELR20636.1 - 9.2e-06 25.5 4.3 0.78 10.1 0.0 5.0 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_7 PF13176.6 ELR20636.1 - 0.0017 18.2 10.1 8.1 6.7 0.1 5.5 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_9 PF13371.6 ELR20636.1 - 0.0042 17.2 0.0 0.0042 17.2 0.0 3.8 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_20 PF14561.6 ELR20636.1 - 0.011 16.1 0.9 23 5.4 0.0 3.6 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_19 PF14559.6 ELR20636.1 - 0.021 15.4 10.3 8.3 7.0 0.1 4.8 3 2 1 4 4 4 0 Tetratricopeptide repeat TPR_12 PF13424.6 ELR20636.1 - 0.049 13.9 6.5 8.2 6.8 0.1 4.1 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_6 PF13174.6 ELR20636.1 - 2.4 9.0 9.8 51 4.8 0.0 4.3 5 0 0 5 5 4 0 Tetratricopeptide repeat Pex14_N PF04695.13 ELR20638.1 - 1.8e-19 70.9 0.0 1.8e-19 70.9 0.0 5.1 3 1 1 4 4 4 1 Peroxisomal membrane anchor protein (Pex14p) conserved region ATP11 PF06644.11 ELR20641.1 - 1.9e-37 129.5 0.0 2.3e-37 129.3 0.0 1.0 1 0 0 1 1 1 1 ATP11 protein Serine_protease PF18405.1 ELR20641.1 - 0.14 11.3 0.1 0.52 9.4 0.1 1.7 2 0 0 2 2 2 0 Gammaproteobacterial serine protease RHD_dimer PF16179.5 ELR20642.1 - 1.1e-05 25.3 0.0 2.6e-05 24.2 0.0 1.7 1 0 0 1 1 1 1 Rel homology dimerisation domain IATP PF04568.12 ELR20642.1 - 0.038 14.4 0.4 0.038 14.4 0.4 2.3 2 0 0 2 2 2 0 Mitochondrial ATPase inhibitor, IATP Neurokinin_B PF03823.14 ELR20642.1 - 0.058 13.4 0.0 0.14 12.2 0.0 1.6 1 0 0 1 1 1 0 Neurokinin B SUIM_assoc PF16619.5 ELR20642.1 - 0.55 10.3 10.5 0.87 9.7 0.5 2.6 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 Alpha_GJ PF03229.13 ELR20642.1 - 3.3 8.3 6.3 1.8 9.1 2.9 2.1 2 0 0 2 2 2 0 Alphavirus glycoprotein J Peroxin-13_N PF04088.13 ELR20643.1 - 1.4e-18 67.5 0.0 2.2e-18 66.9 0.0 1.2 1 0 0 1 1 1 1 Peroxin 13, N-terminal region SH3_2 PF07653.17 ELR20643.1 - 2.7e-12 46.2 0.0 2.7e-12 46.2 0.0 2.4 3 0 0 3 3 3 1 Variant SH3 domain SH3_1 PF00018.28 ELR20643.1 - 2e-11 43.3 0.1 3e-11 42.8 0.1 1.3 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 ELR20643.1 - 5.4e-11 42.2 0.1 1e-10 41.3 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain Aminotran_5 PF00266.19 ELR20644.1 - 7.8e-93 311.4 0.0 1e-92 311.0 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.21 ELR20644.1 - 2.4e-08 33.6 0.0 3.1e-08 33.3 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase DegT_DnrJ_EryC1 PF01041.17 ELR20644.1 - 0.00069 19.0 0.2 0.0012 18.3 0.2 1.3 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family B12-binding PF02310.19 ELR20644.1 - 0.0054 16.8 0.1 2 8.5 0.0 2.4 2 0 0 2 2 2 2 B12 binding domain Pyridoxal_deC PF00282.19 ELR20644.1 - 0.026 13.2 0.0 0.05 12.3 0.0 1.4 1 0 0 1 1 1 0 Pyridoxal-dependent decarboxylase conserved domain Aconitase PF00330.20 ELR20645.1 - 1.8e-150 501.9 0.0 2.3e-150 501.6 0.0 1.1 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 ELR20645.1 - 3.5e-45 153.5 0.0 6.4e-45 152.7 0.0 1.5 1 0 0 1 1 1 1 Aconitase C-terminal domain ILVD_EDD PF00920.21 ELR20647.1 - 7.6e-180 598.9 0.0 8.7e-180 598.7 0.0 1.0 1 0 0 1 1 1 1 Dehydratase family SpoU_methylase PF00588.19 ELR20648.1 - 3e-28 98.8 0.0 1.7e-27 96.4 0.0 2.1 1 1 0 1 1 1 1 SpoU rRNA Methylase family Ribosomal_L19e PF01280.20 ELR20649.1 - 2.2e-16 60.2 2.7 2.9e-16 59.8 2.7 1.2 1 0 0 1 1 1 1 Ribosomal protein L19e DUF4344 PF14247.6 ELR20649.1 - 0.036 13.7 0.0 0.036 13.7 0.0 1.1 1 0 0 1 1 1 0 Putative metallopeptidase MTS PF05175.14 ELR20650.1 - 7.2e-14 51.7 0.0 1e-13 51.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain PrmA PF06325.13 ELR20650.1 - 3e-13 49.9 0.0 4.5e-13 49.3 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_31 PF13847.6 ELR20650.1 - 2.4e-12 46.9 0.0 3e-12 46.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain UPF0020 PF01170.18 ELR20650.1 - 2.2e-10 40.6 0.5 1.4e-09 37.9 0.3 2.1 1 1 0 1 1 1 1 Putative RNA methylase family UPF0020 Methyltransf_25 PF13649.6 ELR20650.1 - 3.9e-10 40.3 0.4 3.3e-09 37.3 0.1 2.1 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_15 PF09445.10 ELR20650.1 - 1.6e-09 37.5 0.0 1.3e-08 34.6 0.0 1.9 1 1 1 2 2 2 1 RNA cap guanine-N2 methyltransferase Cons_hypoth95 PF03602.15 ELR20650.1 - 4.4e-07 29.7 0.0 5.6e-07 29.4 0.0 1.1 1 0 0 1 1 1 1 Conserved hypothetical protein 95 Methyltransf_12 PF08242.12 ELR20650.1 - 9.2e-07 29.5 0.1 3.2e-06 27.8 0.0 1.9 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 ELR20650.1 - 4e-06 27.4 0.3 2.5e-05 24.8 0.2 2.2 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_32 PF13679.6 ELR20650.1 - 6.1e-06 26.3 0.0 9.6e-06 25.7 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.7 ELR20650.1 - 6.3e-06 26.2 0.0 8.1e-06 25.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain DUF43 PF01861.16 ELR20650.1 - 0.00051 19.4 0.0 0.00061 19.1 0.0 1.2 1 0 0 1 1 1 1 Branched-chain polyamine synthase A C-terminal domain Met_10 PF02475.16 ELR20650.1 - 0.0013 18.5 0.0 0.0022 17.8 0.0 1.3 1 1 0 1 1 1 1 Met-10+ like-protein Ubie_methyltran PF01209.18 ELR20650.1 - 0.0017 17.7 0.0 0.0021 17.4 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_16 PF10294.9 ELR20650.1 - 0.0058 16.4 0.0 0.0088 15.8 0.0 1.3 1 0 0 1 1 1 1 Lysine methyltransferase N6-adenineMlase PF10237.9 ELR20650.1 - 0.036 13.9 0.0 0.046 13.5 0.0 1.2 1 0 0 1 1 1 0 Probable N6-adenine methyltransferase Methyltransf_24 PF13578.6 ELR20650.1 - 0.075 14.1 0.2 0.54 11.3 0.0 2.0 1 1 1 2 2 2 0 Methyltransferase domain DOT1 PF08123.13 ELR20650.1 - 0.1 12.1 0.1 0.17 11.4 0.1 1.4 1 1 0 1 1 1 0 Histone methylation protein DOT1 NUDIX PF00293.28 ELR20651.1 - 8e-18 64.7 0.1 2e-17 63.5 0.1 1.6 1 1 1 2 2 2 1 NUDIX domain PEX11 PF05648.14 ELR20652.1 - 2e-43 148.4 3.8 2.3e-43 148.3 3.8 1.0 1 0 0 1 1 1 1 Peroxisomal biogenesis factor 11 (PEX11) GAGA_bind PF06217.12 ELR20653.1 - 0.0045 17.3 2.9 0.0045 17.3 2.9 2.1 2 0 0 2 2 2 1 GAGA binding protein-like family CDC45 PF02724.14 ELR20653.1 - 0.19 10.0 4.7 0.26 9.5 4.7 1.1 1 0 0 1 1 1 0 CDC45-like protein TFIIF_alpha PF05793.12 ELR20653.1 - 5 5.6 19.4 6.9 5.1 19.4 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) ALMT PF11744.8 ELR20653.1 - 5.1 5.8 6.2 9.3 5.0 6.2 1.3 1 0 0 1 1 1 0 Aluminium activated malate transporter Tweety PF04906.13 ELR20654.1 - 6.5e-14 51.4 4.4 5.4e-10 38.5 2.0 2.4 2 0 0 2 2 2 2 Tweety COG5 PF10392.9 ELR20654.1 - 0.32 11.2 1.7 2.8 8.1 0.0 2.8 2 1 1 3 3 3 0 Golgi transport complex subunit 5 RNA_polI_A34 PF08208.11 ELR20655.1 - 0.00067 19.8 21.5 0.00067 19.8 21.5 2.2 3 0 0 3 3 3 1 DNA-directed RNA polymerase I subunit RPA34.5 CDC45 PF02724.14 ELR20655.1 - 0.21 9.8 15.1 0.0051 15.2 6.7 1.9 2 0 0 2 2 2 0 CDC45-like protein Macoilin PF09726.9 ELR20655.1 - 0.53 8.8 16.2 1.2 7.6 16.2 1.5 1 1 0 1 1 1 0 Macoilin family Smg8_Smg9 PF10220.9 ELR20655.1 - 4.3 5.5 11.0 6.1 5.0 11.0 1.1 1 0 0 1 1 1 0 Smg8_Smg9 Elong_Iki1 PF10483.9 ELR20656.1 - 1.7e-13 50.7 0.2 6.2e-07 29.2 1.0 2.1 1 1 1 2 2 2 2 Elongator subunit Iki1 Glyco_transf_34 PF05637.12 ELR20657.1 - 5.9e-13 49.1 1.8 1.4e-06 28.2 0.0 2.4 1 1 1 2 2 2 2 galactosyl transferase GMA12/MNN10 family GRP PF07172.11 ELR20657.1 - 0.028 15.1 13.0 0.05 14.3 13.0 1.3 1 0 0 1 1 1 0 Glycine rich protein family Metallopep PF12044.8 ELR20658.1 - 1.2e-56 192.2 0.0 4.3e-54 183.7 0.0 2.1 1 1 0 1 1 1 1 Putative peptidase family Reprolysin_5 PF13688.6 ELR20658.1 - 0.012 15.8 0.1 0.02 15.1 0.1 1.2 1 0 0 1 1 1 0 Metallo-peptidase family M12 Reprolysin_3 PF13582.6 ELR20658.1 - 0.029 14.9 0.0 0.047 14.2 0.0 1.3 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.6 ELR20658.1 - 0.064 12.9 0.0 0.099 12.3 0.0 1.2 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Peptidase_M66 PF10462.9 ELR20658.1 - 0.066 12.1 0.3 0.11 11.4 0.3 1.2 1 0 0 1 1 1 0 Peptidase M66 Peptidase_M10 PF00413.24 ELR20658.1 - 0.11 12.4 0.0 0.16 11.8 0.0 1.3 1 0 0 1 1 1 0 Matrixin PH PF00169.29 ELR20659.1 - 1.4e-12 48.0 0.1 2.3e-12 47.3 0.1 1.3 1 0 0 1 1 1 1 PH domain PH_9 PF15410.6 ELR20659.1 - 0.0028 18.0 3.9 0.012 15.9 0.1 2.9 2 1 0 2 2 2 1 Pleckstrin homology domain PH_17 PF18012.1 ELR20659.1 - 0.15 11.8 0.0 0.27 11.0 0.0 1.4 1 0 0 1 1 1 0 PH domain Presenilin PF01080.17 ELR20659.1 - 0.3 9.8 1.1 0.34 9.6 1.1 1.2 1 0 0 1 1 1 0 Presenilin PH_12 PF16457.5 ELR20659.1 - 0.35 11.4 2.6 1.2 9.7 0.0 2.2 2 0 0 2 2 2 0 Pleckstrin homology domain Apt1 PF10351.9 ELR20659.1 - 0.71 8.7 5.8 0.87 8.4 5.8 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain DUF5423 PF17461.2 ELR20659.1 - 6.2 5.6 12.1 9 5.0 12.1 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5423) GREB1 PF15782.5 ELR20659.1 - 7.5 3.5 11.7 9.6 3.2 11.7 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer SRP-alpha_N PF04086.13 ELR20659.1 - 8.5 6.2 8.9 13 5.6 8.9 1.2 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal MORN PF02493.20 ELR20660.1 - 1.5e-125 402.1 158.5 4.9e-07 29.3 1.2 22.5 22 0 0 22 22 22 21 MORN repeat F-box-like PF12937.7 ELR20660.1 - 2.5e-07 30.5 0.4 4.1e-07 29.8 0.4 1.3 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ELR20660.1 - 0.0013 18.5 0.3 0.0022 17.9 0.3 1.3 1 0 0 1 1 1 1 F-box domain F-box_4 PF15966.5 ELR20660.1 - 0.013 15.4 2.7 0.024 14.5 2.7 1.3 1 0 0 1 1 1 0 F-box PATR PF12951.7 ELR20660.1 - 0.62 10.2 8.5 10 6.3 0.2 4.5 5 0 0 5 5 5 0 Passenger-associated-transport-repeat SM-ATX PF14438.6 ELR20660.1 - 1.5 9.0 19.4 17 5.7 0.1 8.8 8 2 1 10 10 10 0 Ataxin 2 SM domain D123 PF07065.14 ELR20661.1 - 5.4e-20 71.7 0.0 4.6e-14 52.3 0.0 2.3 2 0 0 2 2 2 2 D123 R2K_2 PF18299.1 ELR20661.1 - 0.013 15.3 0.0 0.046 13.6 0.0 1.8 2 0 0 2 2 2 0 ATP-grasp domain, R2K clade family 2 R2K_3 PF14243.6 ELR20661.1 - 0.042 13.9 0.0 0.089 12.8 0.0 1.5 1 0 0 1 1 1 0 ATP-grasp domain, R2K clade family 3 Herpes_pp85 PF04637.12 ELR20661.1 - 0.32 9.4 5.2 0.47 8.8 5.2 1.1 1 0 0 1 1 1 0 Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25) EMP24_GP25L PF01105.24 ELR20662.1 - 7.7e-48 162.8 0.0 8.9e-48 162.6 0.0 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD SdrD_B PF17210.3 ELR20662.1 - 0.0097 16.1 0.0 0.013 15.7 0.0 1.3 1 0 0 1 1 1 1 SdrD B-like domain Frizzled PF01534.17 ELR20663.1 - 3.5e-16 59.2 21.7 4.9e-16 58.7 21.7 1.1 1 0 0 1 1 1 1 Frizzled/Smoothened family membrane region Fz PF01392.22 ELR20663.1 - 1.8e-06 28.6 0.5 1.8e-06 28.6 0.5 2.1 2 0 0 2 2 2 1 Fz domain Ank_5 PF13857.6 ELR20664.1 - 0.00061 20.0 0.1 0.0038 17.5 0.0 2.2 2 0 0 2 2 2 1 Ankyrin repeats (many copies) F-box-like PF12937.7 ELR20664.1 - 0.0013 18.6 2.2 0.0044 16.9 2.2 2.0 1 1 0 1 1 1 1 F-box-like F-box PF00646.33 ELR20664.1 - 0.0013 18.5 0.0 0.0042 16.9 0.0 1.8 1 0 0 1 1 1 1 F-box domain Ank_2 PF12796.7 ELR20664.1 - 0.0019 18.8 0.0 0.0036 17.9 0.0 1.4 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 ELR20664.1 - 0.012 16.1 0.0 0.31 11.7 0.0 2.6 2 0 0 2 2 2 0 Ankyrin repeat Ank_4 PF13637.6 ELR20664.1 - 0.063 13.9 0.1 7 7.4 0.0 2.7 1 1 1 2 2 2 0 Ankyrin repeats (many copies) DAGK_acc PF00609.19 ELR20665.1 - 3.5e-42 144.5 0.0 5.6e-42 143.8 0.0 1.3 1 0 0 1 1 1 1 Diacylglycerol kinase accessory domain C1_1 PF00130.22 ELR20665.1 - 3.3e-20 71.7 26.5 3.7e-11 42.7 8.8 3.3 3 0 0 3 3 3 2 Phorbol esters/diacylglycerol binding domain (C1 domain) DAGK_cat PF00781.24 ELR20665.1 - 1.4e-11 44.1 0.0 2.5e-11 43.3 0.0 1.4 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain C1_2 PF03107.16 ELR20665.1 - 0.04 14.2 18.9 0.23 11.8 1.4 3.4 3 0 0 3 3 3 0 C1 domain Atrophin-1 PF03154.15 ELR20665.1 - 0.18 10.1 8.4 0.25 9.6 8.4 1.1 1 0 0 1 1 1 0 Atrophin-1 family CDC45 PF02724.14 ELR20665.1 - 1.8 6.7 8.9 2.6 6.3 8.9 1.1 1 0 0 1 1 1 0 CDC45-like protein U3_snoRNA_assoc PF08297.11 ELR20665.1 - 5.6 7.7 11.9 13 6.5 11.9 1.6 1 0 0 1 1 1 0 U3 snoRNA associated Ras PF00071.22 ELR20666.1 - 6.4e-33 113.6 0.0 8.9e-33 113.2 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR20666.1 - 4.3e-18 65.7 0.0 8e-18 64.8 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR20666.1 - 5e-08 32.6 0.0 6.9e-08 32.1 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 ELR20666.1 - 0.092 12.3 0.0 0.13 11.8 0.0 1.2 1 0 0 1 1 1 0 Elongation factor Tu GTP binding domain Pkinase PF00069.25 ELR20667.1 - 4.4e-46 157.4 0.0 4.6e-45 154.0 0.0 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR20667.1 - 1.2e-34 119.8 0.0 1.7e-34 119.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ELR20667.1 - 0.0057 16.0 0.0 0.0089 15.4 0.0 1.3 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 ELR20667.1 - 0.049 13.5 0.0 0.11 12.4 0.0 1.6 1 0 0 1 1 1 0 Phosphotransferase enzyme family SPX PF03105.19 ELR20667.1 - 0.21 11.4 1.9 3.5 7.5 0.0 2.1 2 0 0 2 2 2 0 SPX domain Pex26 PF07163.12 ELR20668.1 - 1.8e-05 24.2 1.1 4.9e-05 22.8 1.1 1.7 1 1 0 1 1 1 1 Pex26 protein Bac_globin PF01152.21 ELR20669.1 - 9.2e-09 35.5 0.1 0.0011 19.1 0.0 2.2 1 1 1 2 2 2 2 Bacterial-like globin 2OG-FeII_Oxy_3 PF13640.6 ELR20670.1 - 1.6e-11 44.9 0.1 2.6e-11 44.3 0.1 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Pox_C4_C10 PF03336.13 ELR20670.1 - 0.00077 18.7 0.0 0.0014 17.8 0.0 1.3 1 0 0 1 1 1 1 Poxvirus C4/C10 protein BTRD1 PF17660.1 ELR20670.1 - 0.052 13.4 0.0 0.094 12.5 0.0 1.4 1 0 0 1 1 1 0 Bacterial tandem repeat domain 1 Cytokin_check_N PF10407.9 ELR20671.1 - 6.5e-08 32.4 0.1 1.2e-07 31.5 0.1 1.3 1 0 0 1 1 1 1 Cdc14 phosphatase binding protein N-terminus TFIIA PF03153.13 ELR20671.1 - 0.056 13.4 24.7 0.044 13.8 7.7 2.3 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Sedlin_N PF04628.13 ELR20672.1 - 9.4e-45 151.9 0.5 1.1e-44 151.8 0.5 1.0 1 0 0 1 1 1 1 Sedlin, N-terminal conserved region Sybindin PF04099.12 ELR20672.1 - 1.3e-09 38.2 0.8 5.9e-09 36.0 0.8 2.0 1 1 0 1 1 1 1 Sybindin-like family UPF0556 PF10572.9 ELR20673.1 - 1.6e-12 47.1 0.0 2e-12 46.9 0.0 1.2 1 0 0 1 1 1 1 Uncharacterised protein family UPF0556 Ras PF00071.22 ELR20674.1 - 2.8e-49 166.8 1.2 6.5e-49 165.6 1.2 1.5 1 1 0 1 1 1 1 Ras family Roc PF08477.13 ELR20674.1 - 2.5e-16 60.0 0.1 1.2e-14 54.6 0.1 2.3 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR20674.1 - 1.1e-07 31.5 0.0 1.7e-07 30.9 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 ELR20674.1 - 7.3e-07 28.9 0.2 2.5e-06 27.2 0.0 1.7 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 ELR20674.1 - 3.9e-06 26.9 0.1 0.0041 17.0 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase ATP_bind_1 PF03029.17 ELR20674.1 - 0.00078 19.3 1.7 0.0023 17.7 0.0 2.0 1 1 1 2 2 2 1 Conserved hypothetical ATP binding protein FeoB_N PF02421.18 ELR20674.1 - 0.0074 15.8 0.9 0.058 12.9 0.9 2.3 1 1 0 1 1 1 1 Ferrous iron transport protein B AAA_25 PF13481.6 ELR20674.1 - 0.012 15.1 0.1 0.14 11.7 0.1 2.1 2 0 0 2 2 2 0 AAA domain AAA_14 PF13173.6 ELR20674.1 - 0.016 15.3 0.1 0.029 14.4 0.1 1.5 1 1 0 1 1 1 0 AAA domain MMR_HSR1 PF01926.23 ELR20674.1 - 0.024 14.7 1.5 1 9.5 1.5 2.3 1 1 0 1 1 1 0 50S ribosome-binding GTPase ABC_tran PF00005.27 ELR20674.1 - 0.065 13.8 0.1 0.097 13.2 0.1 1.5 1 1 0 1 1 1 0 ABC transporter CENP-M PF11111.8 ELR20674.1 - 0.078 12.2 0.1 0.18 11.0 0.0 1.5 2 0 0 2 2 2 0 Centromere protein M (CENP-M) DUF503 PF04456.12 ELR20674.1 - 0.08 12.8 0.0 0.15 11.9 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF503) AAA_16 PF13191.6 ELR20674.1 - 0.1 13.0 0.2 0.21 11.9 0.2 1.7 1 1 0 1 1 1 0 AAA ATPase domain CoA_trans PF01144.23 ELR20674.1 - 0.12 11.7 0.1 0.23 10.8 0.1 1.4 1 0 0 1 1 1 0 Coenzyme A transferase CbiA PF01656.23 ELR20674.1 - 0.18 11.8 0.4 0.39 10.8 0.4 1.6 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain AdoHcyase PF05221.17 ELR20675.1 - 1.9e-148 493.5 0.0 2.2e-148 493.3 0.0 1.0 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase AdoHcyase_NAD PF00670.21 ELR20675.1 - 9.6e-83 276.1 2.5 1.5e-82 275.5 2.5 1.3 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 2-Hacid_dh_C PF02826.19 ELR20675.1 - 2.9e-07 30.0 0.1 5.3e-07 29.2 0.1 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain IlvN PF07991.12 ELR20675.1 - 4.5e-05 23.1 0.1 7.7e-05 22.3 0.1 1.3 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain NAD_binding_7 PF13241.6 ELR20675.1 - 0.0079 16.6 0.4 0.023 15.1 0.4 1.7 1 0 0 1 1 1 1 Putative NAD(P)-binding THF_DHG_CYH_C PF02882.19 ELR20675.1 - 0.025 13.9 1.2 0.15 11.4 1.2 2.1 1 1 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain TrkA_N PF02254.18 ELR20675.1 - 0.033 14.4 0.2 0.096 12.9 0.2 1.8 1 1 0 1 1 1 0 TrkA-N domain 3HCDH_N PF02737.18 ELR20675.1 - 0.043 13.7 0.8 1.1 9.1 0.2 2.3 1 1 1 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Shikimate_DH PF01488.20 ELR20675.1 - 0.15 12.2 0.1 0.39 10.8 0.1 1.7 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Alpha_kinase PF02816.18 ELR20676.1 - 1.7e-39 135.9 0.0 3e-39 135.0 0.0 1.4 1 0 0 1 1 1 1 Alpha-kinase family UCH PF00443.29 ELR20676.1 - 8.4e-31 107.4 0.0 6.3e-30 104.5 0.0 2.0 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 ELR20676.1 - 2.3e-11 43.9 0.5 3.8e-09 36.6 0.5 3.1 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Peptidase_C98 PF15499.6 ELR20676.1 - 5.2e-05 22.9 0.0 0.0066 16.0 0.0 2.3 2 0 0 2 2 2 2 Ubiquitin-specific peptidase-like, SUMO isopeptidase CDP-OH_P_transf PF01066.21 ELR20677.1 - 9.4e-09 35.9 0.3 9.4e-09 35.9 0.3 2.9 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase Spore_YhaL PF14147.6 ELR20677.1 - 0.074 12.7 0.1 0.24 11.1 0.1 1.9 1 0 0 1 1 1 0 Sporulation protein YhaL TMEM208_SND2 PF05620.11 ELR20677.1 - 4.7 7.0 9.6 0.045 13.5 0.8 2.1 3 0 0 3 3 3 0 SRP-independent targeting protein 2/TMEM208 EF-hand_1 PF00036.32 ELR20678.1 - 1e-12 46.6 0.0 1.2e-05 24.5 0.1 2.6 2 0 0 2 2 2 2 EF hand EF-hand_5 PF13202.6 ELR20678.1 - 8.9e-11 40.8 0.1 0.00019 20.7 0.0 2.6 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 ELR20678.1 - 1.1e-10 40.6 0.1 5.1e-05 22.9 0.1 2.7 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.6 ELR20678.1 - 2.3e-08 34.4 0.7 5.5e-08 33.2 0.4 1.8 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.6 ELR20678.1 - 0.00022 21.0 0.1 0.93 9.4 0.0 2.5 2 0 0 2 2 2 2 EF-hand domain pair Frizzled PF01534.17 ELR20679.1 - 3.2e-24 85.6 4.9 4.2e-24 85.2 4.9 1.1 1 0 0 1 1 1 1 Frizzled/Smoothened family membrane region Dicty_CAR PF05462.11 ELR20679.1 - 1.7e-06 27.4 6.2 2.8e-06 26.7 6.2 1.3 1 0 0 1 1 1 1 Slime mold cyclic AMP receptor 7tm_2 PF00002.24 ELR20679.1 - 3.4e-06 26.5 7.3 5.7e-06 25.8 7.3 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) Glyco_hydro_92 PF07971.12 ELR20681.1 - 1.5e-132 442.9 4.0 1.9e-132 442.5 4.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 92 Glyco_hydro_92N PF17678.1 ELR20681.1 - 2.2e-50 171.8 0.5 4.3e-50 170.8 0.5 1.5 1 0 0 1 1 1 1 Glycosyl hydrolase family 92 N-terminal domain SKG6 PF08693.10 ELR20682.1 - 0.0062 15.9 4.3 0.018 14.4 4.3 1.9 1 0 0 1 1 1 1 Transmembrane alpha-helix domain DUF3318 PF11780.8 ELR20682.1 - 0.39 10.7 1.5 7.2 6.6 0.1 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF3318) DUF4659 PF15558.6 ELR20683.1 - 0.2 10.5 0.0 0.2 10.5 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4659) Ras PF00071.22 ELR20684.1 - 1.3e-25 89.8 0.0 2.2e-25 89.1 0.0 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR20684.1 - 5.4e-07 29.9 0.0 9.7e-07 29.0 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Oxidored_molyb PF00174.19 ELR20685.1 - 3e-62 209.3 0.0 5.3e-62 208.4 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase molybdopterin binding domain Mo-co_dimer PF03404.16 ELR20685.1 - 5.5e-46 156.0 1.3 3.3e-45 153.5 0.3 2.6 2 0 0 2 2 2 1 Mo-co oxidoreductase dimerisation domain FAD_binding_6 PF00970.24 ELR20685.1 - 1e-24 86.7 0.0 3.2e-24 85.2 0.0 1.9 2 0 0 2 2 2 1 Oxidoreductase FAD-binding domain Cyt-b5 PF00173.28 ELR20685.1 - 2.7e-18 65.9 0.1 5.1e-18 65.0 0.1 1.5 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain NAD_binding_1 PF00175.21 ELR20685.1 - 6.6e-15 55.7 3.8 3.5e-09 37.3 0.0 3.5 2 1 1 3 3 3 2 Oxidoreductase NAD-binding domain Parvo_coat PF00740.18 ELR20685.1 - 0.11 11.1 1.1 0.16 10.6 1.1 1.1 1 0 0 1 1 1 0 Parvovirus coat protein VP2 NAD_binding_6 PF08030.12 ELR20685.1 - 0.15 12.2 1.0 0.57 10.3 0.0 2.4 3 0 0 3 3 3 0 Ferric reductase NAD binding domain DUF5523 PF17661.1 ELR20685.1 - 0.59 9.8 22.1 0.89 9.2 22.1 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5523) PROCN PF08083.11 ELR20686.1 - 1.2e-235 781.7 6.5 1.8e-235 781.2 6.5 1.2 1 0 0 1 1 1 1 PROCN (NUC071) domain PRP8_domainIV PF12134.8 ELR20686.1 - 3.4e-129 429.3 0.5 3.4e-129 429.3 0.5 1.7 2 0 0 2 2 2 1 PRP8 domain IV core U6-snRNA_bdg PF10596.9 ELR20686.1 - 2.4e-89 297.4 3.3 7.2e-89 295.8 3.3 1.9 1 0 0 1 1 1 1 U6-snRNA interacting domain of PrP8 PRO8NT PF08082.11 ELR20686.1 - 9.1e-86 285.4 4.0 2e-85 284.3 4.0 1.6 1 0 0 1 1 1 1 PRO8NT (NUC069), PrP8 N-terminal domain U5_2-snRNA_bdg PF10597.9 ELR20686.1 - 1.8e-72 241.7 0.0 3.3e-72 240.9 0.0 1.5 1 0 0 1 1 1 1 U5-snRNA binding site 2 of PrP8 RRM_4 PF10598.9 ELR20686.1 - 7e-48 160.9 0.6 1.8e-47 159.6 0.6 1.7 1 0 0 1 1 1 1 RNA recognition motif of the spliceosomal PrP8 PROCT PF08084.11 ELR20686.1 - 4.1e-47 159.1 0.2 1.1e-46 157.7 0.2 1.8 1 0 0 1 1 1 1 PROCT (NUC072) domain JAB PF01398.21 ELR20686.1 - 7.9e-08 32.3 0.0 2.1e-07 31.0 0.0 1.7 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease LAMTOR5 PF16672.5 ELR20687.1 - 1.5e-21 76.1 0.0 1.6e-21 76.0 0.0 1.0 1 0 0 1 1 1 1 Ragulator complex protein LAMTOR5 DEAD PF00270.29 ELR20688.1 - 4.2e-42 143.9 0.1 6.9e-42 143.2 0.1 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ELR20688.1 - 3.3e-31 107.9 0.1 1.9e-28 99.0 0.0 2.5 3 0 0 3 3 3 2 Helicase conserved C-terminal domain ResIII PF04851.15 ELR20688.1 - 3.3e-09 37.0 0.0 7.9e-09 35.7 0.0 1.6 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_19 PF13245.6 ELR20688.1 - 0.001 19.4 0.5 0.0037 17.6 0.2 1.9 2 0 0 2 2 2 1 AAA domain tRNA-synt_1b PF00579.25 ELR20688.1 - 0.01 15.2 0.0 0.026 13.8 0.0 1.6 2 0 0 2 2 2 1 tRNA synthetases class I (W and Y) CMS1 PF14617.6 ELR20688.1 - 0.026 13.9 0.1 0.059 12.7 0.1 1.6 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit Helicase_RecD PF05127.14 ELR20688.1 - 0.079 12.8 0.0 0.13 12.1 0.0 1.4 1 0 0 1 1 1 0 Helicase UvrD-helicase PF00580.21 ELR20688.1 - 0.12 11.9 0.8 0.26 10.8 0.3 1.6 1 1 0 2 2 2 0 UvrD/REP helicase N-terminal domain GFA PF04828.14 ELR20689.1 - 0.076 13.4 1.5 3.6 8.0 0.1 2.2 1 1 1 2 2 2 0 Glutathione-dependent formaldehyde-activating enzyme DUF3039 PF11238.8 ELR20689.1 - 0.078 12.7 0.7 0.12 12.1 0.7 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3039) PMI_typeI PF01238.21 ELR20690.1 - 1.3e-105 353.7 0.0 1.6e-105 353.3 0.0 1.1 1 0 0 1 1 1 1 Phosphomannose isomerase type I Cupin_2 PF07883.11 ELR20690.1 - 0.041 13.6 0.3 2.5 7.9 0.0 2.4 2 0 0 2 2 2 0 Cupin domain 2OG-FeII_Oxy_3 PF13640.6 ELR20691.1 - 5.2e-10 40.1 0.0 1.2e-09 38.9 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy PF03171.20 ELR20691.1 - 0.1 13.1 0.1 0.22 12.0 0.1 1.5 1 1 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily SET PF00856.28 ELR20692.1 - 1.5e-16 61.3 0.0 5.6e-16 59.4 0.0 2.0 1 1 0 1 1 1 1 SET domain SAF PF08666.12 ELR20692.1 - 0.028 15.1 0.0 0.2 12.3 0.1 2.2 2 0 0 2 2 2 0 SAF domain TPR_12 PF13424.6 ELR20692.1 - 0.11 12.8 0.3 1 9.7 0.2 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_6 PF13174.6 ELR20692.1 - 0.26 12.0 1.2 7.4 7.4 0.3 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat zf-MYND PF01753.18 ELR20692.1 - 2 8.5 11.4 0.22 11.6 5.0 2.9 2 0 0 2 2 2 0 MYND finger Cytochrom_B561 PF03188.16 ELR20693.1 - 1.6e-08 34.7 5.7 1.6e-08 34.7 5.7 1.7 2 1 0 2 2 2 1 Eukaryotic cytochrome b561 DUF2427 PF10348.9 ELR20693.1 - 0.13 12.1 4.1 3.3 7.6 0.1 2.6 1 1 1 2 2 2 0 Domain of unknown function (DUF2427) DPM3 PF08285.11 ELR20693.1 - 2.6 8.3 9.4 1.5 9.1 6.9 2.0 2 1 0 2 2 2 0 Dolichol-phosphate mannosyltransferase subunit 3 (DPM3) RFX_DNA_binding PF02257.15 ELR20694.1 - 2.8e-14 53.5 0.3 6.5e-14 52.3 0.1 1.8 2 0 0 2 2 2 1 RFX DNA-binding domain Pkinase_Tyr PF07714.17 ELR20695.1 - 1.4e-61 208.0 0.2 4.8e-61 206.3 0.0 1.9 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.25 ELR20695.1 - 4.1e-52 177.2 0.0 1.2e-51 175.7 0.0 1.8 1 0 0 1 1 1 1 Protein kinase domain SH2 PF00017.24 ELR20695.1 - 2.4e-16 59.6 0.8 1.1e-15 57.4 0.0 2.5 2 0 0 2 2 2 1 SH2 domain FGase PF05013.12 ELR20696.1 - 3.6e-05 24.1 2.6 0.016 15.5 2.6 2.5 1 1 0 1 1 1 1 N-formylglutamate amidohydrolase Band_7 PF01145.25 ELR20697.1 - 2.8e-11 43.8 7.0 1.1e-09 38.6 3.2 4.0 2 2 0 2 2 2 1 SPFH domain / Band 7 family DUF4660 PF15559.6 ELR20697.1 - 0.032 14.5 0.2 0.063 13.6 0.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4660) Cupin_2 PF07883.11 ELR20697.1 - 0.14 11.9 0.0 12 5.6 0.0 2.4 2 0 0 2 2 2 0 Cupin domain ODR4-like PF14778.6 ELR20698.1 - 3.5e-61 207.2 0.0 6.4e-61 206.3 0.0 1.4 2 0 0 2 2 2 1 Olfactory receptor 4-like Pox_Ag35 PF03286.14 ELR20698.1 - 0.0096 15.7 2.4 0.017 14.9 2.4 1.4 1 0 0 1 1 1 1 Pox virus Ag35 surface protein PRC2_HTH_1 PF18118.1 ELR20698.1 - 0.85 10.5 4.7 24 5.8 0.6 2.7 3 0 0 3 3 3 0 Polycomb repressive complex 2 tri-helical domain Methyltransf_32 PF13679.6 ELR20699.1 - 8.3e-05 22.6 6.8 0.0013 18.8 3.3 2.4 2 1 0 2 2 2 1 Methyltransferase domain zf-CCCH_2 PF14608.6 ELR20699.1 - 0.0019 18.6 2.6 0.0039 17.6 2.6 1.6 1 0 0 1 1 1 1 RNA-binding, Nab2-type zinc finger zf-CCCH_3 PF15663.5 ELR20699.1 - 0.0033 17.6 0.1 0.0061 16.8 0.1 1.4 1 0 0 1 1 1 1 Zinc-finger containing family zf-CCCH_4 PF18044.1 ELR20699.1 - 0.64 9.9 6.6 3 7.7 6.6 2.2 1 1 0 1 1 1 0 CCCH-type zinc finger FA_desaturase PF00487.24 ELR20700.1 - 3.1e-27 96.0 16.4 3.7e-27 95.8 15.8 1.4 1 1 0 1 1 1 1 Fatty acid desaturase Cyt-b5 PF00173.28 ELR20700.1 - 3.4e-13 49.5 0.0 7.2e-13 48.5 0.0 1.5 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain CLU PF13236.6 ELR20701.1 - 1.1e-46 159.4 0.0 2.2e-46 158.5 0.0 1.4 1 0 0 1 1 1 1 Clustered mitochondria eIF3_p135 PF12807.7 ELR20701.1 - 1.7e-06 28.2 0.0 6.3e-06 26.3 0.0 2.0 2 0 0 2 2 2 1 Translation initiation factor eIF3 subunit 135 TPR_8 PF13181.6 ELR20701.1 - 2.7e-06 27.1 0.7 0.0051 16.9 0.1 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 ELR20701.1 - 3.3e-05 23.7 5.0 0.079 13.1 0.1 4.2 4 0 0 4 4 3 2 Tetratricopeptide repeat TPR_17 PF13431.6 ELR20701.1 - 6.7e-05 23.0 0.2 0.025 14.9 0.1 3.7 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_1 PF00515.28 ELR20701.1 - 0.0041 16.9 1.0 1.8 8.5 0.1 2.9 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_14 PF13428.6 ELR20701.1 - 0.01 16.5 4.9 0.34 11.9 0.1 4.4 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_19 PF14559.6 ELR20701.1 - 0.018 15.5 0.6 0.55 10.8 0.4 3.0 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_16 PF13432.6 ELR20701.1 - 0.023 15.3 1.8 0.84 10.3 0.6 3.0 3 0 0 3 3 2 0 Tetratricopeptide repeat DUF4632 PF15451.6 ELR20701.1 - 0.13 12.4 0.2 0.46 10.6 0.2 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4632) TPR_7 PF13176.6 ELR20701.1 - 0.14 12.3 0.2 3.8 7.8 0.1 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat Pribosyltran PF00156.27 ELR20702.1 - 2e-10 40.4 0.0 3.4e-10 39.7 0.0 1.3 1 0 0 1 1 1 1 Phosphoribosyl transferase domain Pribosyl_synth PF14572.6 ELR20702.1 - 0.0003 20.9 0.0 0.00047 20.3 0.0 1.2 1 0 0 1 1 1 1 Phosphoribosyl synthetase-associated domain Glyco_hydro_65m PF03632.15 ELR20704.1 - 8.7e-62 209.2 0.0 4.9e-50 170.5 0.2 2.2 1 1 1 2 2 2 2 Glycosyl hydrolase family 65 central catalytic domain DUF2152 PF10222.9 ELR20704.1 - 5.1e-12 44.9 0.0 5.1e-10 38.3 0.0 2.1 2 0 0 2 2 2 2 Uncharacterized conserved protein (DUF2152) Glyco_hydro_65C PF03633.15 ELR20704.1 - 0.0028 17.5 0.0 0.0083 16.0 0.0 1.8 2 0 0 2 2 2 1 Glycosyl hydrolase family 65, C-terminal domain Vif PF00559.17 ELR20704.1 - 0.053 13.2 0.2 0.099 12.3 0.2 1.3 1 0 0 1 1 1 0 Retroviral Vif (Viral infectivity) protein MMR_HSR1 PF01926.23 ELR20705.1 - 5.9e-16 58.6 0.3 2.7e-14 53.2 0.0 3.0 2 0 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 ELR20705.1 - 2.7e-07 30.2 0.8 1.4e-05 24.7 0.1 2.3 2 0 0 2 2 2 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 ELR20705.1 - 8.4e-06 25.8 0.1 0.0096 15.8 0.0 2.6 2 0 0 2 2 2 2 RsgA GTPase Dynamin_N PF00350.23 ELR20705.1 - 0.27 11.3 7.9 2.9 7.9 0.2 3.6 3 1 0 3 3 3 0 Dynamin family Mucin PF01456.17 ELR20705.1 - 1 9.4 7.5 2.8 7.9 7.5 1.7 1 0 0 1 1 1 0 Mucin-like glycoprotein 5_nucleotid_C PF02872.18 ELR20706.1 - 4.4e-26 92.0 0.0 8e-26 91.1 0.0 1.4 1 0 0 1 1 1 1 5'-nucleotidase, C-terminal domain RasGAP PF00616.19 ELR20706.1 - 2.2e-13 50.4 2.8 3e-13 50.0 0.2 2.5 2 1 0 2 2 2 1 GTPase-activator protein for Ras-like GTPase DUF3377 PF11857.8 ELR20706.1 - 0.081 12.9 0.2 0.081 12.9 0.2 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF3377) DUF3827 PF12877.7 ELR20706.1 - 0.56 8.5 2.2 0.58 8.5 0.6 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF3827) RAI16-like PF10257.9 ELR20707.1 - 1.8e-22 79.8 0.0 6.4e-16 58.2 0.0 2.8 1 1 1 2 2 2 2 Retinoic acid induced 16-like protein F-box-like PF12937.7 ELR20708.1 - 8.3e-07 28.8 0.2 2.5e-06 27.3 0.2 1.9 1 0 0 1 1 1 1 F-box-like DUF4632 PF15451.6 ELR20708.1 - 0.0021 18.1 0.1 0.0073 16.4 0.1 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF4632) F-box PF00646.33 ELR20708.1 - 0.0033 17.3 0.1 0.0064 16.4 0.1 1.5 1 0 0 1 1 1 1 F-box domain DUF3370 PF11850.8 ELR20709.1 - 0.0032 16.4 0.0 0.0045 15.9 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3370) Pkinase_Tyr PF07714.17 ELR20711.1 - 1.1e-57 195.3 0.0 1.6e-57 194.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ELR20711.1 - 8.9e-52 176.0 0.0 1.8e-51 175.1 0.0 1.4 2 0 0 2 2 2 1 Protein kinase domain Arrestin_C PF02752.22 ELR20711.1 - 9.8e-08 32.5 0.3 9.8e-08 32.5 0.3 2.1 3 0 0 3 3 3 1 Arrestin (or S-antigen), C-terminal domain APH PF01636.23 ELR20711.1 - 0.00037 20.5 0.2 0.00084 19.3 0.0 1.7 2 0 0 2 2 2 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 ELR20711.1 - 0.0017 17.4 0.4 0.0046 16.0 0.0 1.8 2 0 0 2 2 2 1 Haspin like kinase domain Pkinase_fungal PF17667.1 ELR20711.1 - 0.0068 15.2 0.0 0.013 14.3 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 ELR20711.1 - 0.053 12.9 0.0 0.11 11.9 0.0 1.5 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family DUF2393 PF09624.10 ELR20711.1 - 0.058 13.4 0.8 0.095 12.7 0.8 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2393) RFX_DNA_binding PF02257.15 ELR20712.1 - 0.00019 22.0 1.1 0.00077 20.0 0.4 2.1 2 0 0 2 2 2 1 RFX DNA-binding domain RFX_DNA_binding PF02257.15 ELR20713.1 - 0.00011 22.8 0.0 0.0002 21.9 0.0 1.5 1 0 0 1 1 1 1 RFX DNA-binding domain RFX_DNA_binding PF02257.15 ELR20714.1 - 9.3e-13 48.6 0.1 1.5e-12 47.9 0.1 1.3 1 0 0 1 1 1 1 RFX DNA-binding domain Myotub-related PF06602.14 ELR20715.1 - 6.5e-131 436.4 0.0 8.2e-131 436.1 0.0 1.1 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain RPEL PF02755.15 ELR20716.1 - 0.0047 16.6 0.1 0.0047 16.6 0.1 2.5 3 0 0 3 3 3 1 RPEL repeat Apt1 PF10351.9 ELR20716.1 - 0.51 9.1 12.6 1.9 7.3 1.2 2.3 2 0 0 2 2 2 0 Golgi-body localisation protein domain Nop14 PF04147.12 ELR20716.1 - 0.8 7.8 22.0 1.4 7.0 22.0 1.3 1 0 0 1 1 1 0 Nop14-like family CDC45 PF02724.14 ELR20716.1 - 0.94 7.7 14.3 1.4 7.2 14.3 1.2 1 0 0 1 1 1 0 CDC45-like protein Cwf_Cwc_15 PF04889.12 ELR20716.1 - 7.8 6.2 24.8 20 4.8 24.8 1.7 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein SprT-like PF10263.9 ELR20717.1 - 1.6e-21 76.3 0.0 2.3e-21 75.8 0.0 1.2 1 0 0 1 1 1 1 SprT-like family Peptidase_M76 PF09768.9 ELR20717.1 - 0.18 11.6 0.0 0.25 11.1 0.0 1.3 1 0 0 1 1 1 0 Peptidase M76 family Band_7 PF01145.25 ELR20718.1 - 1.7e-11 44.5 7.0 1.5e-10 41.3 5.3 3.1 2 1 0 2 2 2 1 SPFH domain / Band 7 family GST_C_3 PF14497.6 ELR20719.1 - 1.1e-19 70.4 0.0 1.5e-19 70.0 0.0 1.2 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 ELR20719.1 - 5.8e-12 45.7 0.0 9.6e-12 45.0 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 ELR20719.1 - 1.4e-10 41.4 0.0 2.4e-10 40.6 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 ELR20719.1 - 2.3e-05 24.3 0.1 4.5e-05 23.4 0.1 1.7 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_6 PF17171.4 ELR20719.1 - 0.015 15.1 0.0 0.025 14.4 0.0 1.4 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.6 ELR20719.1 - 0.032 14.5 0.0 0.057 13.7 0.0 1.4 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain TC1 PF15063.6 ELR20719.1 - 0.074 12.9 0.1 0.14 12.0 0.1 1.5 1 0 0 1 1 1 0 Thyroid cancer protein 1 RFX_DNA_binding PF02257.15 ELR20720.1 - 3.7e-11 43.5 0.0 5.3e-11 43.0 0.0 1.2 1 0 0 1 1 1 1 RFX DNA-binding domain RFX_DNA_binding PF02257.15 ELR20721.1 - 5.1e-12 46.2 0.2 7.9e-12 45.6 0.2 1.3 1 0 0 1 1 1 1 RFX DNA-binding domain Dehydrin PF00257.19 ELR20721.1 - 0.031 14.8 0.5 0.04 14.5 0.5 1.2 1 0 0 1 1 1 0 Dehydrin COG4 PF08318.12 ELR20721.1 - 0.055 12.5 0.0 0.065 12.3 0.0 1.2 1 0 0 1 1 1 0 COG4 transport protein SR-25 PF10500.9 ELR20721.1 - 0.29 10.7 4.4 0.4 10.3 4.4 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein RFX_DNA_binding PF02257.15 ELR20722.1 - 0.00032 21.2 0.1 0.00046 20.8 0.1 1.2 1 0 0 1 1 1 1 RFX DNA-binding domain DUF4724 PF15852.5 ELR20722.1 - 0.072 13.6 0.2 0.092 13.2 0.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4724) PAP1 PF08601.10 ELR20722.1 - 3.3 7.4 9.3 3.1 7.4 9.3 1.1 1 0 0 1 1 1 0 Transcription factor PAP1 Glyco_hydro_3_C PF01915.22 ELR20723.1 - 4.2e-53 180.3 0.1 6.7e-53 179.7 0.1 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Glyco_hydro_3 PF00933.21 ELR20723.1 - 2.7e-41 142.0 0.0 9.1e-32 110.7 0.0 2.2 2 0 0 2 2 2 2 Glycosyl hydrolase family 3 N terminal domain Fn3-like PF14310.6 ELR20723.1 - 4.5e-08 33.1 0.0 1e-07 31.9 0.0 1.6 1 0 0 1 1 1 1 Fibronectin type III-like domain Ras PF00071.22 ELR20724.1 - 2.7e-14 53.1 0.2 3.3e-14 52.8 0.2 1.1 1 0 0 1 1 1 1 Ras family Ras PF00071.22 ELR20725.1 - 4.7e-41 140.1 0.0 5.7e-41 139.8 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR20725.1 - 1.8e-32 112.1 0.1 2.2e-32 111.8 0.1 1.0 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR20725.1 - 1.1e-10 41.2 0.0 1.3e-10 41.0 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 ELR20725.1 - 1.8e-05 24.8 0.0 2.1e-05 24.6 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 ELR20725.1 - 0.00042 20.3 0.0 0.00054 19.9 0.0 1.4 1 0 0 1 1 1 1 RsgA GTPase AAA_16 PF13191.6 ELR20725.1 - 0.00091 19.6 0.0 0.0013 19.1 0.0 1.3 1 0 0 1 1 1 1 AAA ATPase domain ABC_tran PF00005.27 ELR20725.1 - 0.0036 17.8 0.1 0.0056 17.2 0.1 1.6 1 1 0 1 1 1 1 ABC transporter Gtr1_RagA PF04670.12 ELR20725.1 - 0.0057 16.0 0.0 0.0063 15.9 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region NTPase_1 PF03266.15 ELR20725.1 - 0.0088 16.0 0.1 0.0099 15.8 0.1 1.2 1 0 0 1 1 1 1 NTPase TniB PF05621.11 ELR20725.1 - 0.0091 15.4 0.0 0.013 15.0 0.0 1.3 1 0 0 1 1 1 1 Bacterial TniB protein AAA_29 PF13555.6 ELR20725.1 - 0.0099 15.6 0.0 0.021 14.5 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_22 PF13401.6 ELR20725.1 - 0.012 15.8 0.1 0.019 15.3 0.1 1.5 1 1 0 1 1 1 0 AAA domain G-alpha PF00503.20 ELR20725.1 - 0.014 14.6 0.1 0.021 14.0 0.1 1.5 1 1 0 1 1 1 0 G-protein alpha subunit AAA_5 PF07728.14 ELR20725.1 - 0.022 14.8 0.1 0.029 14.4 0.1 1.4 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) GTP_EFTU PF00009.27 ELR20725.1 - 0.034 13.7 0.2 0.49 9.9 0.2 2.0 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain AAA_24 PF13479.6 ELR20725.1 - 0.047 13.4 0.4 0.098 12.4 0.1 1.7 1 1 1 2 2 2 0 AAA domain NACHT PF05729.12 ELR20725.1 - 0.066 13.1 0.0 0.099 12.6 0.0 1.3 1 0 0 1 1 1 0 NACHT domain Septin PF00735.18 ELR20725.1 - 0.078 12.2 0.1 0.11 11.8 0.1 1.2 1 0 0 1 1 1 0 Septin AAA_7 PF12775.7 ELR20725.1 - 0.082 12.4 0.1 0.12 11.8 0.1 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region SRPRB PF09439.10 ELR20725.1 - 0.13 11.7 0.0 0.14 11.6 0.0 1.1 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit DAP3 PF10236.9 ELR20725.1 - 0.13 11.4 0.1 0.19 10.8 0.1 1.2 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 Rad17 PF03215.15 ELR20725.1 - 0.18 11.7 0.0 0.18 11.7 0.0 1.2 1 0 0 1 1 1 0 Rad17 P-loop domain IMS PF00817.20 ELR20727.1 - 3.3e-34 118.0 0.1 8.5e-34 116.7 0.0 1.7 2 0 0 2 2 2 1 impB/mucB/samB family IMS_HHH PF11798.8 ELR20727.1 - 6.4e-07 29.3 0.1 1.9e-05 24.7 0.1 2.8 2 0 0 2 2 2 1 IMS family HHH motif IMS_C PF11799.8 ELR20727.1 - 6.1e-06 26.9 0.2 2.3e-05 25.0 0.2 1.9 2 0 0 2 2 2 1 impB/mucB/samB family C-terminal domain DUF737 PF05300.11 ELR20727.1 - 0.0026 18.1 0.2 0.0057 17.0 0.2 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF737) DUF2824 PF11039.8 ELR20727.1 - 0.077 13.0 0.0 0.17 11.9 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2824) KIAA1430 PF13879.6 ELR20727.1 - 0.088 13.6 1.9 0.2 12.4 1.9 1.6 1 0 0 1 1 1 0 KIAA1430 homologue Ribonuc_red_2_N PF08471.10 ELR20727.1 - 0.16 12.2 0.3 2 8.7 0.0 2.5 3 0 0 3 3 3 0 Class II vitamin B12-dependent ribonucleotide reductase Laminin_II PF06009.12 ELR20727.1 - 0.25 11.4 2.1 2.3 8.2 0.7 2.4 2 0 0 2 2 2 0 Laminin Domain II CGI-121 PF08617.10 ELR20728.1 - 3.5e-28 98.8 0.1 4.1e-28 98.5 0.1 1.0 1 0 0 1 1 1 1 Kinase binding protein CGI-121 TPR_2 PF07719.17 ELR20729.1 - 1.5e-09 37.3 10.2 0.0015 18.5 0.2 4.0 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.6 ELR20729.1 - 3.3e-09 36.8 5.4 0.35 11.8 0.1 4.8 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_19 PF14559.6 ELR20729.1 - 4.9e-09 36.6 7.6 0.05 14.1 0.9 4.5 2 1 2 4 4 4 3 Tetratricopeptide repeat TPR_16 PF13432.6 ELR20729.1 - 9.1e-09 35.8 10.7 9.5e-05 23.0 0.1 3.7 2 1 2 4 4 4 3 Tetratricopeptide repeat TPR_8 PF13181.6 ELR20729.1 - 2.3e-08 33.6 3.6 0.014 15.6 0.1 3.8 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_7 PF13176.6 ELR20729.1 - 6.6e-06 25.8 4.2 0.79 9.9 0.1 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_9 PF13371.6 ELR20729.1 - 3.6e-05 23.8 3.0 0.012 15.7 0.3 2.9 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_17 PF13431.6 ELR20729.1 - 5.8e-05 23.2 0.9 0.012 15.9 0.2 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.6 ELR20729.1 - 6.6e-05 23.1 8.1 0.0033 17.7 1.0 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat ANAPC3 PF12895.7 ELR20729.1 - 0.00015 21.9 4.1 0.0013 18.9 3.8 2.2 2 0 0 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_1 PF00515.28 ELR20729.1 - 0.00016 21.3 7.6 0.13 12.1 0.3 3.8 4 0 0 4 4 4 2 Tetratricopeptide repeat Alkyl_sulf_dimr PF14863.6 ELR20729.1 - 0.0047 17.4 0.2 1.6 9.2 0.0 2.3 2 0 0 2 2 2 1 Alkyl sulfatase dimerisation TPR_10 PF13374.6 ELR20729.1 - 0.014 15.3 1.2 2.1 8.3 0.3 2.8 3 0 0 3 3 3 0 Tetratricopeptide repeat NARP1 PF12569.8 ELR20729.1 - 0.015 14.3 0.6 0.18 10.7 0.3 2.0 2 0 0 2 2 2 0 NMDA receptor-regulated protein 1 TPR_6 PF13174.6 ELR20729.1 - 0.42 11.3 10.5 64 4.5 0.1 5.2 6 0 0 6 6 5 0 Tetratricopeptide repeat MIT PF04212.18 ELR20729.1 - 1.2 9.2 4.5 2.6 8.2 0.0 3.3 3 0 0 3 3 3 0 MIT (microtubule interacting and transport) domain TPR_11 PF13414.6 ELR20729.1 - 2.8 7.7 5.1 36 4.1 0.4 3.2 3 0 0 3 3 3 0 TPR repeat Ras PF00071.22 ELR20730.1 - 3.2e-28 98.4 0.0 4.3e-28 97.9 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR20730.1 - 3e-15 56.5 0.0 4.7e-15 55.9 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR20730.1 - 1.5e-05 24.6 0.0 2.1e-05 24.1 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 ELR20730.1 - 0.0012 18.4 0.0 0.004 16.7 0.0 1.7 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain G-alpha PF00503.20 ELR20730.1 - 0.031 13.5 0.0 0.035 13.3 0.0 1.2 1 0 0 1 1 1 0 G-protein alpha subunit MMR_HSR1_Xtn PF16897.5 ELR20730.1 - 0.039 14.0 0.0 0.064 13.3 0.0 1.4 1 0 0 1 1 1 0 C-terminal region of MMR_HSR1 domain Glycos_transf_2 PF00535.26 ELR20731.1 - 1.8e-11 44.1 2.7 4.4e-07 29.9 0.0 2.8 2 1 1 3 3 3 2 Glycosyl transferase family 2 Glyco_tranf_2_2 PF10111.9 ELR20731.1 - 0.0002 21.0 0.3 0.00073 19.1 0.3 1.9 1 1 0 1 1 1 1 Glycosyltransferase like family 2 SASA PF03629.18 ELR20731.1 - 0.11 12.2 0.0 0.17 11.5 0.0 1.2 1 0 0 1 1 1 0 Carbohydrate esterase, sialic acid-specific acetylesterase zf-C3HC4_2 PF13923.6 ELR20732.1 - 2.9e-10 39.8 9.9 4.5e-10 39.2 9.9 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 ELR20732.1 - 3e-10 39.8 7.3 4.3e-10 39.3 7.3 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 ELR20732.1 - 3.4e-10 39.6 4.6 5.3e-10 39.0 4.6 1.1 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 ELR20732.1 - 7.9e-09 35.7 9.7 1.1e-08 35.2 9.7 1.2 1 0 0 1 1 1 1 Ring finger domain zf-RING_UBOX PF13445.6 ELR20732.1 - 1.4e-08 34.6 7.6 1.9e-07 31.0 8.7 2.1 1 1 1 2 2 2 1 RING-type zinc-finger zf-RING_5 PF14634.6 ELR20732.1 - 1.9e-07 30.9 5.8 2.8e-07 30.4 5.8 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_4 PF15227.6 ELR20732.1 - 2.7e-06 27.4 10.2 4e-06 26.9 10.2 1.3 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING Prok-RING_4 PF14447.6 ELR20732.1 - 5.3e-06 26.2 6.6 7.8e-06 25.7 6.6 1.2 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-ANAPC11 PF12861.7 ELR20732.1 - 9.6e-05 22.4 1.7 0.00014 21.8 1.7 1.3 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-rbx1 PF12678.7 ELR20732.1 - 0.00041 20.6 7.9 0.00076 19.7 7.9 1.4 1 0 0 1 1 1 1 RING-H2 zinc finger domain Baculo_IE-1 PF05290.11 ELR20732.1 - 0.00058 19.8 3.7 0.00087 19.3 3.7 1.2 1 0 0 1 1 1 1 Baculovirus immediate-early protein (IE-0) U-box PF04564.15 ELR20732.1 - 0.013 15.6 0.0 0.046 13.9 0.0 1.8 1 1 1 2 2 2 0 U-box domain zf-RING_6 PF14835.6 ELR20732.1 - 0.085 12.7 2.5 0.15 11.9 2.5 1.4 1 0 0 1 1 1 0 zf-RING of BARD1-type protein zf-RING_10 PF16685.5 ELR20732.1 - 0.19 11.9 4.2 0.33 11.1 4.2 1.4 1 0 0 1 1 1 0 zinc RING finger of MSL2 IBR PF01485.21 ELR20732.1 - 2.4 8.4 7.5 2.2 8.6 5.8 1.8 1 1 0 1 1 1 0 IBR domain, a half RING-finger domain MFS_1 PF07690.16 ELR20733.1 - 1e-18 67.4 39.5 5e-13 48.7 10.6 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily Nodulin-like PF06813.13 ELR20733.1 - 1.2e-05 24.9 7.7 1.2e-05 24.9 7.7 2.7 2 2 0 2 2 2 1 Nodulin-like GATA PF00320.27 ELR20734.1 - 2.9e-14 52.4 3.7 5.5e-14 51.5 3.7 1.5 1 0 0 1 1 1 1 GATA zinc finger MRC1 PF09444.10 ELR20734.1 - 0.021 15.3 0.6 0.021 15.3 0.6 2.0 2 0 0 2 2 2 0 MRC1-like domain OrfB_Zn_ribbon PF07282.11 ELR20734.1 - 0.097 12.6 0.6 0.2 11.6 0.6 1.5 1 0 0 1 1 1 0 Putative transposase DNA-binding domain zf-NADH-PPase PF09297.11 ELR20734.1 - 0.26 11.0 2.8 8.7 6.1 0.2 2.4 2 0 0 2 2 2 0 NADH pyrophosphatase zinc ribbon domain GATA PF00320.27 ELR20735.1 - 1.7e-10 40.3 1.3 1.7e-10 40.3 1.3 2.1 2 0 0 2 2 2 1 GATA zinc finger Spc7_N PF15402.6 ELR20735.1 - 5.2 5.2 18.0 6.8 4.8 18.0 1.1 1 0 0 1 1 1 0 N-terminus of kinetochore NMS complex subunit Spc7 CLU PF13236.6 ELR20736.1 - 1.2e-61 208.3 0.0 2.3e-61 207.4 0.0 1.4 1 0 0 1 1 1 1 Clustered mitochondria TPR_11 PF13414.6 ELR20736.1 - 4.1e-08 32.8 0.4 4.1e-08 32.8 0.4 4.2 5 0 0 5 5 4 2 TPR repeat eIF3_p135 PF12807.7 ELR20736.1 - 9.4e-08 32.3 0.9 6.3e-07 29.6 0.9 2.2 1 1 0 1 1 1 1 Translation initiation factor eIF3 subunit 135 TPR_17 PF13431.6 ELR20736.1 - 5.4e-07 29.6 2.0 0.083 13.3 0.0 4.4 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.6 ELR20736.1 - 5.7e-06 26.7 6.9 0.014 16.2 0.1 4.6 5 0 0 5 5 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 ELR20736.1 - 9.9e-06 25.3 6.3 0.11 12.7 0.0 5.9 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_1 PF00515.28 ELR20736.1 - 0.00046 19.9 9.1 0.19 11.6 0.0 5.0 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_19 PF14559.6 ELR20736.1 - 0.00096 19.6 7.3 0.039 14.5 0.1 4.3 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_12 PF13424.6 ELR20736.1 - 0.0012 19.1 0.8 0.018 15.3 0.3 2.9 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_8 PF13181.6 ELR20736.1 - 0.01 16.0 2.0 18 5.9 0.8 4.5 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_7 PF13176.6 ELR20736.1 - 0.014 15.4 0.1 0.24 11.5 0.0 3.0 3 0 0 3 3 2 0 Tetratricopeptide repeat TPR_6 PF13174.6 ELR20736.1 - 0.033 14.8 1.6 5.4 7.9 0.5 4.2 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_9 PF13371.6 ELR20736.1 - 0.074 13.2 0.3 0.31 11.2 0.3 2.1 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_16 PF13432.6 ELR20736.1 - 5.2 7.8 10.6 0.06 14.0 1.0 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat BACK PF07707.15 ELR20737.1 - 1.3e-16 60.6 1.6 4.6e-14 52.4 0.3 3.8 4 0 0 4 4 4 1 BTB And C-terminal Kelch zf-trcl PF13451.6 ELR20737.1 - 2.1e-05 24.3 2.0 4.4e-05 23.3 2.0 1.5 1 0 0 1 1 1 1 Probable zinc-ribbon domain BTB PF00651.31 ELR20737.1 - 0.004 17.4 0.0 0.94 9.7 0.0 2.5 2 0 0 2 2 2 2 BTB/POZ domain Band_3_cyto PF07565.13 ELR20737.1 - 0.13 12.1 0.2 0.28 11.0 0.2 1.5 1 0 0 1 1 1 0 Band 3 cytoplasmic domain CDC45 PF02724.14 ELR20737.1 - 0.97 7.6 10.6 1.5 7.0 10.6 1.2 1 0 0 1 1 1 0 CDC45-like protein p450 PF00067.22 ELR20738.1 - 2.5e-91 306.7 0.0 3.1e-91 306.5 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Usp PF00582.26 ELR20739.1 - 3.3e-27 95.7 0.5 2.9e-25 89.4 0.5 2.0 1 1 0 1 1 1 1 Universal stress protein family CheY-binding PF09078.11 ELR20739.1 - 0.055 13.6 0.3 16 5.7 0.0 2.5 2 0 0 2 2 2 0 CheY binding Methyltransf_16 PF10294.9 ELR20740.1 - 4e-15 56.0 0.0 1.8e-14 53.9 0.0 1.8 1 1 0 1 1 1 1 Lysine methyltransferase GidB PF02527.15 ELR20740.1 - 0.0072 15.7 0.2 0.018 14.4 0.0 1.6 2 0 0 2 2 2 1 rRNA small subunit methyltransferase G Methyltransf_23 PF13489.6 ELR20740.1 - 0.014 15.2 0.0 0.027 14.3 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_25 PF13649.6 ELR20740.1 - 0.023 15.4 0.0 0.11 13.2 0.1 2.1 2 0 0 2 2 2 0 Methyltransferase domain SAM_MT PF04445.13 ELR20740.1 - 0.05 13.0 0.9 0.39 10.1 0.0 2.1 2 0 0 2 2 2 0 Putative SAM-dependent methyltransferase TehB PF03848.14 ELR20740.1 - 0.11 11.8 0.0 0.33 10.3 0.0 1.7 3 0 0 3 3 3 0 Tellurite resistance protein TehB MIP PF00230.20 ELR20741.1 - 8.1e-37 127.1 11.4 1.2e-36 126.6 11.4 1.2 1 0 0 1 1 1 1 Major intrinsic protein COX2-transmemb PF09125.10 ELR20741.1 - 1.6 8.6 4.7 11 5.9 0.0 3.3 3 0 0 3 3 3 0 Cytochrome C oxidase subunit II, transmembrane Atg14 PF10186.9 ELR20742.1 - 0.00054 19.1 0.3 0.00068 18.8 0.3 1.1 1 0 0 1 1 1 1 Vacuolar sorting 38 and autophagy-related subunit 14 Leu_zip PF15294.6 ELR20742.1 - 0.0077 15.8 1.2 0.0096 15.5 1.2 1.1 1 0 0 1 1 1 1 Leucine zipper TAF4 PF05236.14 ELR20742.1 - 0.042 13.6 5.0 0.059 13.1 5.0 1.1 1 0 0 1 1 1 0 Transcription initiation factor TFIID component TAF4 family PAS_8 PF13188.7 ELR20742.1 - 0.045 13.8 0.0 0.13 12.3 0.0 1.7 1 0 0 1 1 1 0 PAS domain Sporozoite_P67 PF05642.11 ELR20742.1 - 0.18 9.8 1.8 0.25 9.4 1.8 1.2 1 0 0 1 1 1 0 Sporozoite P67 surface antigen TPR_MLP1_2 PF07926.12 ELR20742.1 - 0.41 10.7 8.9 0.62 10.1 8.9 1.2 1 0 0 1 1 1 0 TPR/MLP1/MLP2-like protein Serglycin PF04360.12 ELR20742.1 - 0.46 10.4 3.7 0.82 9.6 3.7 1.3 1 0 0 1 1 1 0 Serglycin GrpE PF01025.19 ELR20742.1 - 0.62 9.7 7.6 0.94 9.1 7.6 1.2 1 0 0 1 1 1 0 GrpE Herpes_UL25 PF01499.16 ELR20742.1 - 1.8 7.0 3.9 2.8 6.4 3.9 1.1 1 0 0 1 1 1 0 Herpesvirus UL25 family COG2 PF06148.11 ELR20742.1 - 1.9 8.6 4.0 3.3 7.8 4.0 1.4 1 0 0 1 1 1 0 COG (conserved oligomeric Golgi) complex component, COG2 DUF3987 PF13148.6 ELR20742.1 - 2.4 7.1 9.9 3.7 6.5 9.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3987) MCU PF04678.13 ELR20742.1 - 2.6 8.1 4.0 3.7 7.6 4.0 1.2 1 0 0 1 1 1 0 Mitochondrial calcium uniporter Rep_fac-A_C PF08646.10 ELR20743.1 - 8.8e-30 103.4 0.1 4.9e-29 100.9 0.1 2.0 2 0 0 2 2 2 1 Replication factor-A C terminal domain LRR_6 PF13516.6 ELR20743.1 - 5.5e-20 69.7 2.4 0.019 15.0 0.0 10.9 11 0 0 11 11 11 4 Leucine Rich repeat LRR_4 PF12799.7 ELR20743.1 - 1.4e-14 53.9 0.0 0.0031 17.9 0.0 7.2 6 2 2 8 8 8 3 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 ELR20743.1 - 0.00018 21.6 5.6 4.3 8.3 0.0 7.2 10 0 0 10 10 10 1 Leucine Rich Repeat LRR_8 PF13855.6 ELR20743.1 - 0.024 14.4 0.9 1.2 8.9 0.0 4.0 3 1 1 4 4 4 0 Leucine rich repeat SAP PF02037.27 ELR20743.1 - 0.036 13.8 0.1 0.074 12.8 0.1 1.6 1 0 0 1 1 1 0 SAP domain UBM PF14377.6 ELR20743.1 - 1.7 8.2 6.4 2.2 7.8 0.6 2.9 2 0 0 2 2 2 0 Ubiquitin binding region Hep_core_N PF08290.11 ELR20743.1 - 3 7.9 5.3 5.3 7.1 3.5 2.3 2 0 0 2 2 2 0 Hepatitis core protein, putative zinc finger Sar8_2 PF03058.14 ELR20744.1 - 0.089 13.3 0.4 0.089 13.3 0.4 1.6 2 0 0 2 2 2 0 Sar8.2 family RIG-I_C PF18119.1 ELR20744.1 - 0.13 12.3 3.9 0.16 11.9 3.4 1.4 1 1 0 1 1 1 0 RIG-I receptor C-terminal domain Acetyltransf_4 PF13420.7 ELR20745.1 - 6.3e-24 84.9 0.0 7.3e-24 84.7 0.0 1.0 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 ELR20745.1 - 8.8e-13 48.5 0.1 1.1e-12 48.2 0.1 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 ELR20745.1 - 5.5e-08 32.8 0.0 7.7e-08 32.3 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 ELR20745.1 - 1.5e-07 31.7 0.1 2.2e-07 31.2 0.1 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.7 ELR20745.1 - 4.8e-07 30.5 0.0 5.8e-07 30.3 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 ELR20745.1 - 3.7e-06 26.8 0.0 5.4e-06 26.3 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_6 PF13480.7 ELR20745.1 - 0.0043 17.2 0.2 0.0062 16.7 0.2 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.6 ELR20745.1 - 0.017 14.8 0.0 0.044 13.5 0.0 1.8 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain GNAT_acetyltran PF12746.7 ELR20745.1 - 0.044 13.3 0.0 0.054 13.1 0.0 1.1 1 0 0 1 1 1 0 GNAT acetyltransferase Aldo_ket_red PF00248.21 ELR20746.1 - 6.5e-57 193.0 0.0 8.9e-57 192.5 0.0 1.2 1 0 0 1 1 1 1 Aldo/keto reductase family DUF4796 PF16044.5 ELR20747.1 - 1.8e-23 83.1 2.2 2.4e-23 82.7 0.0 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF4796) ZZ PF00569.17 ELR20747.1 - 4.5e-15 55.2 19.1 9.3e-08 31.8 5.9 2.6 2 0 0 2 2 2 2 Zinc finger, ZZ type C1_2 PF03107.16 ELR20747.1 - 0.00057 20.2 22.0 0.0067 16.7 6.4 2.8 3 0 0 3 3 3 2 C1 domain UIM PF02809.20 ELR20747.1 - 0.024 14.5 2.4 0.052 13.5 2.4 1.6 1 0 0 1 1 1 0 Ubiquitin interaction motif Sec66 PF09802.9 ELR20747.1 - 0.17 11.5 0.0 0.26 10.8 0.0 1.2 1 0 0 1 1 1 0 Preprotein translocase subunit Sec66 Histone PF00125.24 ELR20748.1 - 2.7e-34 118.3 2.7 1.8e-19 70.4 0.6 2.0 2 0 0 2 2 2 2 Core histone H2A/H2B/H3/H4 PAF PF15715.5 ELR20748.1 - 0.0018 18.9 1.5 0.0022 18.6 1.5 1.1 1 0 0 1 1 1 1 PCNA-associated factor histone like domain CENP-S PF15630.6 ELR20748.1 - 0.068 13.6 0.0 0.12 12.7 0.0 1.4 1 0 0 1 1 1 0 CENP-S protein hSac2 PF12456.8 ELR20749.1 - 1.9e-11 43.7 0.0 4.7e-11 42.4 0.0 1.6 1 0 0 1 1 1 1 Inositol phosphatase TT_ORF2a PF08197.11 ELR20750.1 - 0.069 13.2 0.1 0.12 12.4 0.1 1.4 1 0 0 1 1 1 0 pORF2a truncated protein FYVE PF01363.21 ELR20751.1 - 1.9e-07 31.1 23.8 3.8e-07 30.2 10.6 2.7 2 0 0 2 2 2 2 FYVE zinc finger YL1 PF05764.13 ELR20751.1 - 0.00035 20.8 13.1 0.00035 20.8 13.1 2.6 2 1 0 2 2 2 1 YL1 nuclear protein Pox_RNA_Pol_19 PF05320.12 ELR20751.1 - 0.42 10.6 6.3 0.93 9.4 6.3 1.5 1 0 0 1 1 1 0 Poxvirus DNA-directed RNA polymerase 19 kDa subunit RRN3 PF05327.11 ELR20751.1 - 2.1 6.8 8.8 3.7 6.0 8.8 1.3 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 eIF3_subunit PF08597.10 ELR20751.1 - 3.9 7.3 28.4 13 5.7 23.3 2.4 2 0 0 2 2 2 0 Translation initiation factor eIF3 subunit DUF3246 PF11596.8 ELR20751.1 - 6.8 6.1 9.0 0.84 9.0 4.8 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3246) Nop53 PF07767.11 ELR20751.1 - 7.1 5.9 26.1 0.46 9.8 16.0 2.3 2 0 0 2 2 2 0 Nop53 (60S ribosomal biogenesis) LRR_8 PF13855.6 ELR20752.1 - 1.2e-18 66.6 13.5 1.2e-09 37.8 0.4 5.2 3 1 3 6 6 6 4 Leucine rich repeat LRR_4 PF12799.7 ELR20752.1 - 1.2e-17 63.7 23.4 1.4e-05 25.4 0.6 6.5 5 3 2 7 7 7 5 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 ELR20752.1 - 3.3e-06 26.9 19.2 20 6.2 0.1 9.0 7 1 0 7 7 7 1 Leucine Rich Repeat LRR_6 PF13516.6 ELR20752.1 - 0.0099 15.9 27.3 4.1 7.7 0.9 7.5 9 0 0 9 9 9 4 Leucine Rich repeat PBD PF00786.28 ELR20752.1 - 0.012 15.9 0.1 0.012 15.9 0.1 2.1 2 0 0 2 2 2 0 P21-Rho-binding domain NPR3 PF03666.13 ELR20752.1 - 0.042 12.6 1.1 0.066 12.0 1.1 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Bul1_N PF04425.12 ELR20752.1 - 0.23 10.2 3.0 0.42 9.3 3.0 1.3 1 0 0 1 1 1 0 Bul1 N terminus Kelch_5 PF13854.6 ELR20753.1 - 1.5e-10 40.8 3.0 0.0096 15.9 0.3 3.5 3 0 0 3 3 3 3 Kelch motif Kelch_3 PF13415.6 ELR20753.1 - 2.9e-09 37.0 0.7 0.026 14.8 0.0 4.3 4 0 0 4 4 4 3 Galactose oxidase, central domain Kelch_4 PF13418.6 ELR20753.1 - 1.5e-08 34.5 1.0 0.14 12.2 0.0 3.9 3 0 0 3 3 3 3 Galactose oxidase, central domain Kelch_6 PF13964.6 ELR20753.1 - 3.2e-08 33.6 4.1 0.037 14.3 0.0 4.4 3 1 1 4 4 4 3 Kelch motif Kelch_1 PF01344.25 ELR20753.1 - 2.1e-07 30.4 1.2 0.00078 19.0 0.0 3.7 4 0 0 4 4 4 2 Kelch motif Kelch_2 PF07646.15 ELR20753.1 - 3.9e-06 26.6 1.6 0.031 14.3 0.0 3.8 3 0 0 3 3 3 2 Kelch motif I_LWEQ PF01608.17 ELR20754.1 - 3e-30 105.5 0.7 3e-30 105.5 0.7 2.0 2 0 0 2 2 2 1 I/LWEQ domain PH PF00169.29 ELR20754.1 - 9.5e-05 22.9 0.1 0.00018 22.0 0.1 1.4 1 0 0 1 1 1 1 PH domain IQ_SEC7_PH PF16453.5 ELR20754.1 - 0.074 13.0 0.0 0.17 11.8 0.0 1.6 1 0 0 1 1 1 0 PH domain Kinesin PF00225.23 ELR20755.1 - 5.6e-99 331.2 0.0 8.4e-99 330.6 0.0 1.2 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 ELR20755.1 - 1.8e-18 66.9 0.0 3.8e-18 65.8 0.0 1.6 1 0 0 1 1 1 1 Microtubule binding U-box PF04564.15 ELR20755.1 - 6.3e-12 45.5 0.0 3.8e-11 43.0 0.0 2.2 2 0 0 2 2 2 1 U-box domain F-box-like PF12937.7 ELR20755.1 - 1.1e-08 34.8 0.1 2e-08 34.0 0.1 1.4 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ELR20755.1 - 1.4e-06 28.0 0.2 2.9e-06 27.0 0.2 1.5 1 0 0 1 1 1 1 F-box domain zf-Nse PF11789.8 ELR20755.1 - 0.00033 20.4 0.0 0.00084 19.1 0.0 1.6 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit F-box_4 PF15966.5 ELR20755.1 - 0.027 14.3 0.0 0.053 13.4 0.0 1.4 1 0 0 1 1 1 0 F-box zf-NOSIP PF15906.5 ELR20755.1 - 0.065 13.4 0.0 0.15 12.2 0.0 1.6 1 0 0 1 1 1 0 Zinc-finger of nitric oxide synthase-interacting protein Cas_CXXC_CXXC PF09706.10 ELR20756.1 - 0.21 11.9 1.6 1.1 9.6 0.0 2.5 3 0 0 3 3 3 0 CRISPR-associated protein (Cas_CXXC_CXXC) Rap_GAP PF02145.15 ELR20757.1 - 8.5e-62 208.0 0.0 1.4e-61 207.3 0.0 1.3 1 0 0 1 1 1 1 Rap/ran-GAP LRR_8 PF13855.6 ELR20757.1 - 1.1e-27 95.5 41.4 5.4e-09 35.7 0.6 6.6 1 1 5 6 6 6 6 Leucine rich repeat LRR_4 PF12799.7 ELR20757.1 - 1.4e-16 60.3 44.7 3.9e-06 27.1 2.9 6.5 4 1 2 7 7 7 5 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 ELR20757.1 - 0.54 11.0 36.1 1.3 9.9 0.1 9.3 9 1 1 10 10 10 0 Leucine Rich Repeat LRR_6 PF13516.6 ELR20757.1 - 8 6.8 32.0 34 4.9 0.1 8.1 8 0 0 8 8 8 0 Leucine Rich repeat Glyco_tranf_2_4 PF13704.6 ELR20758.1 - 0.0084 16.6 0.7 0.029 14.9 0.2 2.1 2 0 0 2 2 2 1 Glycosyl transferase family 2 Cofilin_ADF PF00241.20 ELR20759.1 - 6.5e-23 80.8 0.0 9.5e-23 80.3 0.0 1.3 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein SH3_1 PF00018.28 ELR20759.1 - 5.1e-15 54.8 0.1 1e-14 53.8 0.1 1.6 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 ELR20759.1 - 1.5e-12 47.0 0.0 5e-12 45.3 0.0 1.9 2 0 0 2 2 2 1 Variant SH3 domain SH3_9 PF14604.6 ELR20759.1 - 2.4e-12 46.5 0.2 6.6e-12 45.1 0.1 1.8 2 0 0 2 2 2 1 Variant SH3 domain SH3_10 PF17902.1 ELR20759.1 - 0.027 14.5 0.0 0.056 13.5 0.0 1.5 1 0 0 1 1 1 0 SH3 domain GRP PF07172.11 ELR20759.1 - 0.044 14.5 14.1 0.12 13.1 14.1 1.7 1 0 0 1 1 1 0 Glycine rich protein family FH2 PF02181.23 ELR20760.1 - 1.1e-37 130.1 2.1 1.1e-37 130.1 2.1 2.6 2 0 0 2 2 2 1 Formin Homology 2 Domain Drf_GBD PF06371.13 ELR20760.1 - 9.5e-37 126.4 0.1 9.5e-37 126.4 0.1 3.3 4 0 0 4 4 4 1 Diaphanous GTPase-binding Domain Drf_FH3 PF06367.16 ELR20760.1 - 2.5e-17 63.2 4.4 7.9e-17 61.5 1.5 3.1 2 1 0 2 2 2 1 Diaphanous FH3 Domain DUF3361 PF11841.8 ELR20760.1 - 1.1e-05 25.5 3.6 0.00038 20.4 0.5 4.1 1 1 2 3 3 3 1 Domain of unknown function (DUF3361) Cnn_1N PF07989.11 ELR20760.1 - 0.023 14.8 4.2 0.74 10.0 0.2 3.3 2 0 0 2 2 2 0 Centrosomin N-terminal motif 1 MMS22L_C PF14911.6 ELR20760.1 - 0.045 12.8 1.0 0.18 10.8 0.0 2.3 2 1 0 2 2 2 0 S-phase genomic integrity recombination mediator, C-terminal DUF148 PF02520.17 ELR20760.1 - 1 9.5 7.7 0.39 10.8 0.4 3.1 3 0 0 3 3 3 0 Domain of unknown function DUF148 DASH_Spc19 PF08287.11 ELR20760.1 - 3.4 7.6 11.0 0.34 10.8 3.3 2.8 2 0 0 2 2 2 0 Spc19 FH2 PF02181.23 ELR20761.1 - 2.1e-41 142.3 1.3 2.2e-41 142.2 0.1 1.6 1 1 1 2 2 2 1 Formin Homology 2 Domain DUF1840 PF08895.11 ELR20761.1 - 0.024 15.0 1.7 0.045 14.1 1.7 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1840) DUF908 PF06012.12 ELR20761.1 - 0.044 13.2 0.3 0.057 12.8 0.3 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF908) ANF_receptor PF01094.28 ELR20761.1 - 0.15 11.1 0.4 0.25 10.4 0.3 1.3 1 1 0 1 1 1 0 Receptor family ligand binding region SOAR PF16533.5 ELR20761.1 - 0.21 11.6 4.0 28 4.8 0.0 2.7 2 0 0 2 2 2 0 STIM1 Orai1-activating region PH PF00169.29 ELR20762.1 - 2.5e-11 44.0 0.7 4.1e-11 43.3 0.7 1.4 1 0 0 1 1 1 1 PH domain PH_8 PF15409.6 ELR20762.1 - 4e-08 33.4 0.3 6.3e-08 32.8 0.3 1.3 1 0 0 1 1 1 1 Pleckstrin homology domain PH_3 PF14593.6 ELR20762.1 - 0.0001 22.3 0.0 0.00017 21.7 0.0 1.3 1 0 0 1 1 1 1 PH domain PH_6 PF15406.6 ELR20762.1 - 0.0075 16.5 0.0 0.016 15.5 0.0 1.5 1 0 0 1 1 1 1 Pleckstrin homology domain PH_11 PF15413.6 ELR20762.1 - 0.012 16.1 3.5 0.035 14.5 3.5 2.0 1 1 0 1 1 1 0 Pleckstrin homology domain DUF3027 PF11228.8 ELR20762.1 - 0.049 13.7 1.6 0.089 12.8 1.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3027) Sec7 PF01369.20 ELR20763.1 - 3.3e-63 212.7 0.1 5e-63 212.1 0.1 1.2 1 0 0 1 1 1 1 Sec7 domain PH PF00169.29 ELR20763.1 - 5e-07 30.2 0.0 1.2e-06 29.0 0.0 1.6 1 0 0 1 1 1 1 PH domain PRIMA1 PF16101.5 ELR20763.1 - 0.015 15.3 6.4 0.037 14.1 6.4 1.6 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 Mito_fiss_reg PF05308.11 ELR20763.1 - 0.85 9.7 4.4 2.4 8.2 4.4 1.7 1 0 0 1 1 1 0 Mitochondrial fission regulator CAP_N PF01213.19 ELR20763.1 - 6.9 6.0 14.7 1.8 7.9 9.0 2.2 2 0 0 2 2 2 0 Adenylate cyclase associated (CAP) N terminal Sdh_cyt PF01127.22 ELR20764.1 - 0.00067 19.7 5.5 0.0012 18.9 0.5 2.3 2 0 0 2 2 2 1 Succinate dehydrogenase/Fumarate reductase transmembrane subunit DUF4405 PF14358.6 ELR20764.1 - 0.014 15.9 0.2 7.6 7.2 0.0 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4405) Ferric_reduct PF01794.19 ELR20764.1 - 0.78 9.9 7.4 0.21 11.7 0.8 2.7 2 1 0 3 3 3 0 Ferric reductase like transmembrane component XAP5 PF04921.14 ELR20765.1 - 6.6e-69 232.5 23.9 9.1e-68 228.8 23.9 2.4 1 1 0 1 1 1 1 XAP5, circadian clock regulator DUF1488 PF07369.11 ELR20765.1 - 0.14 12.1 1.4 2.4 8.2 0.1 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF1488) TBCC_N PF16752.5 ELR20765.1 - 0.21 12.0 16.4 0.071 13.6 9.2 2.7 2 1 0 2 2 2 0 Tubulin-specific chaperone C N-terminal domain DUF2570 PF10828.8 ELR20765.1 - 3.2 7.6 7.5 5.8 6.8 0.3 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF2570) Chorein_N PF12624.7 ELR20767.1 - 4.7e-13 49.3 2.8 5.8e-13 49.0 0.1 2.6 3 0 0 3 3 3 1 N-terminal region of Chorein or VPS13 BUD22 PF09073.10 ELR20767.1 - 0.55 9.5 8.7 2.5 7.3 9.0 1.9 1 1 0 1 1 1 0 BUD22 ATG_C PF09333.11 ELR20768.1 - 2.6e-22 79.0 0.0 6.4e-22 77.7 0.0 1.7 1 0 0 1 1 1 1 Autophagy-related protein C terminal domain ATG2_CAD PF13329.6 ELR20768.1 - 4.2e-05 23.3 0.0 0.00012 21.8 0.0 1.8 1 0 0 1 1 1 1 Autophagy-related protein 2 CAD motif VPS13_C PF16909.5 ELR20768.1 - 0.0017 18.1 0.0 0.0063 16.3 0.0 1.8 2 0 0 2 2 2 1 Vacuolar-sorting-associated 13 protein C-terminal SR-25 PF10500.9 ELR20768.1 - 9.3 5.8 32.8 0.05 13.2 8.3 4.2 4 0 0 4 4 4 0 Nuclear RNA-splicing-associated protein PB1 PF00564.24 ELR20769.1 - 0.027 14.4 0.1 0.1 12.6 0.0 2.0 2 1 0 2 2 2 0 PB1 domain YabA PF06156.13 ELR20769.1 - 0.029 15.0 0.2 0.065 13.9 0.1 1.6 2 0 0 2 2 2 0 Initiation control protein YabA PQQ_2 PF13360.6 ELR20770.1 - 0.0024 17.5 0.0 0.0026 17.4 0.0 1.0 1 0 0 1 1 1 1 PQQ-like domain PQQ PF01011.21 ELR20770.1 - 0.073 13.0 0.0 12 6.0 0.0 2.2 2 0 0 2 2 2 0 PQQ enzyme repeat CENP-H PF05837.12 ELR20771.1 - 0.011 16.1 0.2 0.017 15.6 0.2 1.2 1 0 0 1 1 1 0 Centromere protein H (CENP-H) YabA PF06156.13 ELR20771.1 - 0.031 14.9 0.8 0.061 14.0 0.6 1.5 2 0 0 2 2 2 0 Initiation control protein YabA PB1 PF00564.24 ELR20771.1 - 0.044 13.7 0.0 0.1 12.6 0.0 1.7 1 0 0 1 1 1 0 PB1 domain Cep57_CLD_2 PF14197.6 ELR20771.1 - 0.067 13.3 4.1 0.12 12.5 4.1 1.4 1 0 0 1 1 1 0 Centrosome localisation domain of PPC89 PB1 PF00564.24 ELR20772.1 - 2.9e-06 27.1 0.1 6.7e-06 26.0 0.0 1.7 2 0 0 2 2 2 1 PB1 domain Tachylectin PF14517.6 ELR20773.1 - 0.0034 16.9 5.8 0.012 15.2 5.6 1.8 1 1 1 2 2 2 2 Tachylectin HisKA PF00512.25 ELR20775.1 - 1.7e-17 63.2 0.4 8.8e-17 60.9 0.1 2.3 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain Pkinase PF00069.25 ELR20775.1 - 3.9e-13 49.4 0.0 7.5e-13 48.5 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR20775.1 - 5.1e-06 26.0 0.0 1.9e-05 24.1 0.0 1.8 1 1 0 1 1 1 1 Protein tyrosine kinase GAF_2 PF13185.6 ELR20775.1 - 9.3e-06 26.0 0.7 3.8e-05 24.0 0.0 2.5 3 1 0 3 3 3 1 GAF domain GAF PF01590.26 ELR20775.1 - 9.4e-06 26.3 0.0 5.4e-05 23.8 0.0 2.4 2 0 0 2 2 2 1 GAF domain GAF_3 PF13492.6 ELR20775.1 - 0.00061 20.1 0.0 0.0018 18.6 0.0 1.9 1 0 0 1 1 1 1 GAF domain TspO_MBR PF03073.15 ELR20776.1 - 1.3e-08 34.9 9.4 1.3e-08 34.9 9.4 1.5 1 1 0 1 1 1 1 TspO/MBR family SLBP_RNA_bind PF15247.6 ELR20776.1 - 0.0088 16.1 0.9 0.017 15.3 0.9 1.4 1 0 0 1 1 1 1 Histone RNA hairpin-binding protein RNA-binding domain TRM PF02005.16 ELR20777.1 - 3.3e-123 411.6 0.0 4.2e-123 411.3 0.0 1.1 1 0 0 1 1 1 1 N2,N2-dimethylguanosine tRNA methyltransferase Met_10 PF02475.16 ELR20777.1 - 0.00016 21.5 0.0 0.0003 20.6 0.0 1.4 1 0 0 1 1 1 1 Met-10+ like-protein Cons_hypoth95 PF03602.15 ELR20777.1 - 0.011 15.4 0.0 0.18 11.4 0.0 2.4 3 0 0 3 3 3 0 Conserved hypothetical protein 95 Methyltransf_25 PF13649.6 ELR20777.1 - 0.067 13.9 0.0 0.2 12.4 0.0 1.9 1 0 0 1 1 1 0 Methyltransferase domain PrmA PF06325.13 ELR20777.1 - 0.1 12.0 0.5 0.18 11.2 0.5 1.3 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) CH PF00307.31 ELR20778.1 - 2.5e-12 46.9 0.1 9.6e-12 45.1 0.0 2.1 2 0 0 2 2 2 1 Calponin homology (CH) domain CDC24 PF06395.11 ELR20778.1 - 0.057 13.7 0.0 0.15 12.4 0.0 1.6 1 0 0 1 1 1 0 CDC24 Calponin Rgp1 PF08737.10 ELR20778.1 - 0.59 9.2 5.9 1 8.4 5.9 1.4 1 0 0 1 1 1 0 Rgp1 SBF2 PF12335.8 ELR20779.1 - 1.7e-05 24.5 0.5 1.7e-05 24.5 0.5 2.3 2 1 0 2 2 2 1 Myotubularin protein HTH_9 PF08221.11 ELR20779.1 - 0.15 12.2 0.0 0.27 11.3 0.0 1.3 1 0 0 1 1 1 0 RNA polymerase III subunit RPC82 helix-turn-helix domain Borrelia_P83 PF05262.11 ELR20779.1 - 1.1 7.7 21.4 1.4 7.3 21.4 1.2 1 0 0 1 1 1 0 Borrelia P83/100 protein Nucleo_P87 PF07267.11 ELR20779.1 - 4.1 6.1 17.1 6.2 5.5 17.1 1.2 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 CDC45 PF02724.14 ELR20779.1 - 9.3 4.4 21.7 1.7 6.9 0.1 2.1 2 0 0 2 2 2 0 CDC45-like protein TspO_MBR PF03073.15 ELR20780.1 - 3.6e-12 46.5 10.1 8.9e-12 45.2 10.1 1.6 1 1 0 1 1 1 1 TspO/MBR family Sulf_transp PF04143.14 ELR20781.1 - 1.1e-39 136.8 28.0 1.3e-39 136.6 28.0 1.1 1 0 0 1 1 1 1 Sulphur transport HEAT PF02985.22 ELR20782.1 - 5.5e-07 29.3 7.4 0.00055 20.0 0.7 5.2 5 0 0 5 5 5 2 HEAT repeat HEAT_2 PF13646.6 ELR20782.1 - 2.6e-06 27.7 7.0 0.069 13.5 0.2 4.9 3 1 1 4 4 4 3 HEAT repeats MyTH4 PF00784.17 ELR20782.1 - 3e-05 24.4 0.1 0.00014 22.3 0.0 2.2 2 0 0 2 2 2 1 MyTH4 domain HEAT_EZ PF13513.6 ELR20782.1 - 3.2e-05 24.3 8.9 0.0002 21.8 0.1 5.3 5 1 0 5 5 5 1 HEAT-like repeat RIX1 PF08167.12 ELR20782.1 - 0.12 12.1 0.3 22 4.7 0.0 3.5 3 0 0 3 3 3 0 rRNA processing/ribosome biogenesis ThiF PF00899.21 ELR20783.1 - 1.6e-29 103.0 0.0 2e-29 102.7 0.0 1.3 1 1 0 1 1 1 1 ThiF family Shikimate_DH PF01488.20 ELR20783.1 - 0.065 13.3 0.7 1.3 9.1 0.2 2.4 1 1 1 2 2 2 0 Shikimate / quinate 5-dehydrogenase ADH_zinc_N PF00107.26 ELR20783.1 - 0.11 12.5 0.0 0.24 11.4 0.0 1.6 1 0 0 1 1 1 0 Zinc-binding dehydrogenase GSDH PF07995.11 ELR20785.1 - 2.1e-08 33.8 1.5 1e-07 31.6 1.6 2.1 2 1 0 2 2 2 1 Glucose / Sorbosone dehydrogenase WD40 PF00400.32 ELR20786.1 - 7.8e-07 29.7 6.7 3.4 8.7 0.0 6.6 7 0 0 7 7 7 2 WD domain, G-beta repeat Nup160 PF11715.8 ELR20786.1 - 0.008 14.9 3.1 0.055 12.1 1.6 2.4 1 1 2 3 3 3 1 Nucleoporin Nup120/160 PALB2_WD40 PF16756.5 ELR20786.1 - 0.018 14.0 0.4 3.2 6.6 0.1 2.2 2 0 0 2 2 2 0 Partner and localizer of BRCA2 WD40 domain DUF2368 PF10166.9 ELR20787.1 - 0.14 11.7 0.1 0.19 11.3 0.1 1.2 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2368) Aminotran_1_2 PF00155.21 ELR20788.1 - 1.6e-49 169.0 0.0 1.9e-49 168.8 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II DegT_DnrJ_EryC1 PF01041.17 ELR20788.1 - 0.00017 21.0 0.0 0.00027 20.3 0.0 1.2 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_5 PF00266.19 ELR20788.1 - 0.0077 15.2 0.0 0.023 13.7 0.0 1.7 2 1 1 3 3 3 1 Aminotransferase class-V Vta1_C PF18097.1 ELR20788.1 - 0.011 15.5 0.0 0.021 14.5 0.0 1.4 1 0 0 1 1 1 0 Vta1 C-terminal domain Beta_elim_lyase PF01212.21 ELR20788.1 - 0.16 11.2 0.0 0.3 10.3 0.0 1.4 1 0 0 1 1 1 0 Beta-eliminating lyase DUF647 PF04884.14 ELR20789.1 - 2.7e-22 79.6 0.4 3.7e-22 79.1 0.4 1.2 1 0 0 1 1 1 1 Vitamin B6 photo-protection and homoeostasis FUSC_2 PF13515.6 ELR20789.1 - 0.0015 18.6 0.7 0.0032 17.6 0.7 1.5 1 0 0 1 1 1 1 Fusaric acid resistance protein-like DUF647 PF04884.14 ELR20790.1 - 1.8e-31 109.7 0.0 2.1e-31 109.4 0.0 1.0 1 0 0 1 1 1 1 Vitamin B6 photo-protection and homoeostasis DUF3827 PF12877.7 ELR20791.1 - 0.027 12.9 0.4 0.037 12.4 0.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3827) RasGEF PF00617.19 ELR20792.1 - 3.3e-38 131.6 0.0 5.6e-38 130.9 0.0 1.3 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 ELR20792.1 - 9.7e-16 57.9 0.0 3.7e-15 56.0 0.0 2.0 1 1 1 2 2 2 1 RasGEF N-terminal motif F-box-like PF12937.7 ELR20792.1 - 2.3e-09 37.0 0.1 2.3e-09 37.0 0.1 2.3 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 ELR20792.1 - 0.0017 18.2 0.5 0.0073 16.2 0.1 2.3 3 0 0 3 3 3 1 F-box domain Ribosomal_60s PF00428.19 ELR20792.1 - 0.017 15.7 1.6 0.017 15.7 1.6 3.4 4 0 0 4 4 4 0 60s Acidic ribosomal protein DSPc PF00782.20 ELR20793.1 - 1.3e-26 92.9 0.0 1.9e-26 92.5 0.0 1.2 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 ELR20793.1 - 0.00014 21.5 0.0 0.00032 20.3 0.0 1.5 2 0 0 2 2 2 1 Protein-tyrosine phosphatase PTPlike_phytase PF14566.6 ELR20793.1 - 0.0039 17.3 0.0 0.0057 16.8 0.0 1.3 1 0 0 1 1 1 1 Inositol hexakisphosphate Init_tRNA_PT PF04179.12 ELR20793.1 - 0.044 14.1 0.0 0.098 13.0 0.0 1.6 1 0 0 1 1 1 0 Rit1 DUSP-like domain Y_phosphatase3 PF13350.6 ELR20793.1 - 0.08 12.9 0.0 0.12 12.4 0.0 1.2 1 0 0 1 1 1 0 Tyrosine phosphatase family zf-dskA_traR PF01258.17 ELR20793.1 - 0.083 12.8 0.1 0.18 11.8 0.1 1.5 1 0 0 1 1 1 0 Prokaryotic dksA/traR C4-type zinc finger RhoGEF PF00621.20 ELR20794.1 - 8.3e-24 84.8 4.2 9.3e-23 81.4 4.2 2.4 1 1 0 1 1 1 1 RhoGEF domain PH PF00169.29 ELR20794.1 - 1.5e-08 35.1 0.0 3.4e-08 33.9 0.0 1.6 1 0 0 1 1 1 1 PH domain PH_13 PF16652.5 ELR20794.1 - 0.002 18.0 1.1 0.002 18.0 1.1 2.6 2 1 0 2 2 2 1 Pleckstrin homology domain IQ_SEC7_PH PF16453.5 ELR20794.1 - 0.14 12.1 0.2 0.14 12.1 0.2 1.9 2 0 0 2 2 2 0 PH domain adh_short PF00106.25 ELR20795.1 - 1.8e-08 34.1 0.0 3.2e-08 33.3 0.0 1.4 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ELR20795.1 - 3.9e-06 26.6 0.0 5.9e-06 26.0 0.0 1.3 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase NAD_binding_7 PF13241.6 ELR20795.1 - 0.025 15.0 0.1 0.047 14.1 0.1 1.5 1 0 0 1 1 1 0 Putative NAD(P)-binding GDP_Man_Dehyd PF16363.5 ELR20795.1 - 0.031 13.7 0.0 0.051 13.0 0.0 1.3 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase AlaDh_PNT_C PF01262.21 ELR20795.1 - 0.031 13.6 0.3 0.064 12.5 0.3 1.5 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Sacchrp_dh_NADP PF03435.18 ELR20795.1 - 0.034 14.4 0.1 0.053 13.8 0.1 1.3 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain KR PF08659.10 ELR20795.1 - 0.044 13.7 0.3 0.072 13.0 0.2 1.4 1 1 0 1 1 1 0 KR domain Epimerase PF01370.21 ELR20795.1 - 0.048 13.1 0.8 0.086 12.3 0.3 1.6 2 0 0 2 2 2 0 NAD dependent epimerase/dehydratase family Shikimate_DH PF01488.20 ELR20795.1 - 0.06 13.4 0.0 0.11 12.6 0.0 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase 3HCDH_N PF02737.18 ELR20795.1 - 0.065 13.1 0.1 0.12 12.2 0.1 1.5 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain THF_DHG_CYH_C PF02882.19 ELR20795.1 - 0.093 12.0 0.4 0.16 11.3 0.1 1.5 2 0 0 2 2 2 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain DUF1776 PF08643.10 ELR20795.1 - 0.11 11.8 0.0 0.18 11.2 0.0 1.2 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) DAO PF01266.24 ELR20795.1 - 0.5 9.9 7.0 8.9 5.8 3.5 2.3 1 1 0 2 2 2 0 FAD dependent oxidoreductase RasGAP PF00616.19 ELR20796.1 - 3.1e-43 147.9 0.8 3.1e-43 147.9 0.8 3.8 3 0 0 3 3 3 1 GTPase-activator protein for Ras-like GTPase Glutaredoxin2_C PF04399.13 ELR20796.1 - 0.21 11.4 1.5 3 7.7 0.3 3.1 2 0 0 2 2 2 0 Glutaredoxin 2, C terminal domain Kei1 PF08552.11 ELR20796.1 - 3.7 7.4 0.0 3.7 7.4 0.0 3.1 3 1 0 3 3 3 0 Inositolphosphorylceramide synthase subunit Kei1 TPR_2 PF07719.17 ELR20797.1 - 2.4e-12 45.9 14.2 0.004 17.2 0.2 7.7 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_12 PF13424.6 ELR20797.1 - 6.1e-07 29.6 24.1 0.002 18.3 1.5 6.4 6 1 0 6 6 6 3 Tetratricopeptide repeat TPR_8 PF13181.6 ELR20797.1 - 4.3e-06 26.5 0.3 0.71 10.2 0.1 5.0 5 0 0 5 5 5 2 Tetratricopeptide repeat ANAPC3 PF12895.7 ELR20797.1 - 1.4e-05 25.2 11.4 0.031 14.5 0.0 4.4 4 0 0 4 4 4 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_1 PF00515.28 ELR20797.1 - 2.4e-05 24.0 12.7 0.0026 17.5 0.2 5.9 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_7 PF13176.6 ELR20797.1 - 0.0001 22.0 6.1 1.4 9.1 0.0 5.7 6 0 0 6 6 6 1 Tetratricopeptide repeat DUF3856 PF12968.7 ELR20797.1 - 0.00039 20.5 1.9 0.049 13.7 0.3 3.2 2 0 0 2 2 2 1 Domain of Unknown Function (DUF3856) TPR_14 PF13428.6 ELR20797.1 - 0.00055 20.5 13.4 6.1 7.9 0.0 6.3 6 0 0 6 6 5 1 Tetratricopeptide repeat SRP_TPR_like PF17004.5 ELR20797.1 - 0.003 17.6 0.6 1.1 9.2 0.0 3.3 2 1 1 3 3 3 1 Putative TPR-like repeat TPR_16 PF13432.6 ELR20797.1 - 0.0085 16.7 27.7 1.2 9.9 0.2 7.2 7 0 0 7 7 6 2 Tetratricopeptide repeat TPR_19 PF14559.6 ELR20797.1 - 0.0087 16.5 19.8 0.39 11.3 1.2 6.9 5 2 2 7 7 6 2 Tetratricopeptide repeat TPR_6 PF13174.6 ELR20797.1 - 0.011 16.4 14.4 0.5 11.1 0.1 6.3 8 0 0 8 8 5 0 Tetratricopeptide repeat PPR PF01535.20 ELR20797.1 - 0.21 11.9 0.2 2 8.8 0.0 2.8 3 0 0 3 3 3 0 PPR repeat TPR_17 PF13431.6 ELR20797.1 - 0.45 11.0 4.0 47 4.7 0.2 5.4 5 1 1 6 6 6 0 Tetratricopeptide repeat TPR_4 PF07721.14 ELR20797.1 - 1.6 9.6 0.0 1.6 9.6 0.0 7.2 9 0 0 9 9 6 0 Tetratricopeptide repeat TPR_11 PF13414.6 ELR20797.1 - 1.7 8.4 15.0 1.5 8.6 1.6 5.2 5 1 1 6 6 6 0 TPR repeat Fis1_TPR_C PF14853.6 ELR20797.1 - 3.2 7.9 9.1 25 5.1 0.2 5.3 7 0 0 7 7 7 0 Fis1 C-terminal tetratricopeptide repeat TPR_20 PF14561.6 ELR20797.1 - 5.3 7.4 17.8 11 6.4 1.5 5.4 4 2 3 7 7 7 0 Tetratricopeptide repeat CLU PF13236.6 ELR20798.1 - 2.3e-55 187.8 0.0 6e-55 186.5 0.0 1.7 1 0 0 1 1 1 1 Clustered mitochondria TPR_12 PF13424.6 ELR20798.1 - 7.4e-36 122.3 16.3 3.3e-07 30.5 0.3 7.0 5 2 1 6 6 6 5 Tetratricopeptide repeat TPR_10 PF13374.6 ELR20798.1 - 1.9e-21 75.2 22.7 1.2e-07 31.3 0.1 8.3 9 0 0 9 9 8 5 Tetratricopeptide repeat TPR_7 PF13176.6 ELR20798.1 - 1.1e-09 37.6 16.1 0.00052 19.9 0.1 7.0 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_1 PF00515.28 ELR20798.1 - 7.9e-08 31.8 19.7 0.01 15.7 0.1 7.2 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_8 PF13181.6 ELR20798.1 - 2.3e-07 30.5 26.1 0.018 15.2 0.3 7.2 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_2 PF07719.17 ELR20798.1 - 7.3e-07 28.8 29.7 0.014 15.4 0.2 8.3 8 0 0 8 8 8 2 Tetratricopeptide repeat eIF3_p135 PF12807.7 ELR20798.1 - 2.3e-06 27.8 0.0 2.3e-06 27.8 0.0 3.6 3 0 0 3 3 3 1 Translation initiation factor eIF3 subunit 135 Synaptobrevin PF00957.21 ELR20798.1 - 5e-06 26.2 0.3 1.1e-05 25.1 0.3 1.6 1 0 0 1 1 1 1 Synaptobrevin TFIIA PF03153.13 ELR20798.1 - 0.0006 19.9 22.3 0.0006 19.9 22.3 4.7 4 1 1 5 5 3 1 Transcription factor IIA, alpha/beta subunit TPR_4 PF07721.14 ELR20798.1 - 0.0017 18.8 2.7 3 8.7 0.1 5.4 5 0 0 5 5 4 1 Tetratricopeptide repeat TPR_14 PF13428.6 ELR20798.1 - 0.0027 18.4 12.6 6.8 7.8 0.2 6.7 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_MalT PF17874.1 ELR20798.1 - 0.0091 15.4 25.6 0.0082 15.6 5.6 3.6 3 1 2 5 5 5 3 MalT-like TPR region PPR PF01535.20 ELR20798.1 - 0.11 12.8 1.8 1.6 9.1 0.0 3.5 4 0 0 4 4 2 0 PPR repeat Glucokinase PF02685.16 ELR20798.1 - 0.53 9.2 2.8 0.42 9.5 0.1 2.1 2 1 0 2 2 2 0 Glucokinase TPR_19 PF14559.6 ELR20798.1 - 1 9.9 18.3 3.4 8.2 0.7 6.1 5 1 1 6 6 6 0 Tetratricopeptide repeat SRF-TF PF00319.18 ELR20798.1 - 8.9 5.9 6.3 24 4.5 6.3 1.8 1 0 0 1 1 1 0 SRF-type transcription factor (DNA-binding and dimerisation domain) LIAS_N PF16881.5 ELR20799.1 - 3.6e-10 40.2 0.1 1.8e-09 38.0 0.1 2.1 2 0 0 2 2 2 1 N-terminal domain of lipoyl synthase of Radical_SAM family Radical_SAM PF04055.21 ELR20799.1 - 3.1e-09 37.4 0.0 5.1e-09 36.7 0.0 1.3 1 0 0 1 1 1 1 Radical SAM superfamily SR-25 PF10500.9 ELR20799.1 - 0.13 11.9 6.0 0.26 10.9 6.0 1.5 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein BPL_LplA_LipB PF03099.19 ELR20800.1 - 8.1e-09 35.5 0.2 7.2e-05 22.7 0.0 2.9 2 1 1 3 3 3 2 Biotin/lipoate A/B protein ligase family ADH_N_assoc PF13823.6 ELR20800.1 - 0.45 10.5 4.5 0.6 10.1 0.2 2.3 2 0 0 2 2 2 0 Alcohol dehydrogenase GroES-associated GST_C_3 PF14497.6 ELR20801.1 - 3.7e-18 65.5 0.0 5.2e-18 65.1 0.0 1.2 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 ELR20801.1 - 4.9e-11 42.8 0.0 8.6e-11 42.0 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 ELR20801.1 - 9.9e-11 41.7 0.0 3.5e-10 40.0 0.0 2.0 2 1 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 ELR20801.1 - 1.4e-06 28.6 0.0 2.5e-06 27.8 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 ELR20801.1 - 6e-05 23.0 0.0 0.00014 21.8 0.0 1.8 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain CAS_CSE1 PF03378.15 ELR20801.1 - 0.16 10.5 0.0 0.2 10.1 0.0 1.1 1 0 0 1 1 1 0 CAS/CSE protein, C-terminus DNMT1-RFD PF12047.8 ELR20803.1 - 2.1e-11 44.0 0.3 1.2e-10 41.6 0.3 2.0 1 1 0 1 1 1 1 Cytosine specific DNA methyltransferase replication foci domain GST_C_3 PF14497.6 ELR20804.1 - 1.1e-17 64.0 2.3 1.2e-17 63.9 0.0 2.2 3 0 0 3 3 3 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 ELR20804.1 - 7.3e-11 42.3 0.0 1.7e-10 41.0 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 ELR20804.1 - 1.9e-10 40.8 3.0 8.1e-10 38.8 0.0 3.0 3 1 0 3 3 3 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 ELR20804.1 - 2.7e-06 27.7 0.0 5.2e-06 26.8 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 ELR20804.1 - 0.00011 22.2 0.0 0.0003 20.7 0.0 1.9 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain CMS1 PF14617.6 ELR20804.1 - 2.5 7.4 5.6 4.2 6.6 5.6 1.2 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit CDC45 PF02724.14 ELR20804.1 - 4.5 5.5 6.9 5.6 5.1 6.9 1.1 1 0 0 1 1 1 0 CDC45-like protein PHD PF00628.29 ELR20806.1 - 7.7e-22 76.9 22.9 3.7e-12 45.9 7.9 2.7 2 0 0 2 2 2 2 PHD-finger Zf_RING PF16744.5 ELR20806.1 - 0.0037 17.4 17.6 0.02 15.0 4.1 2.8 1 1 0 2 2 2 2 KIAA1045 RING finger zf-HC5HC2H PF13771.6 ELR20806.1 - 0.09 13.0 20.3 0.51 10.6 6.7 2.9 1 1 1 2 2 2 0 PHD-like zinc-binding domain Presenilin PF01080.17 ELR20806.1 - 3.2 6.4 35.6 0.19 10.4 4.6 2.2 2 0 0 2 2 2 0 Presenilin zf-HC5HC2H_2 PF13832.6 ELR20806.1 - 5.1 7.3 20.0 0.38 10.9 4.4 2.5 1 1 1 2 2 2 0 PHD-zinc-finger like domain VWA PF00092.28 ELR20807.1 - 4.7e-11 43.2 0.1 6.5e-10 39.5 0.0 2.6 2 1 0 2 2 2 1 von Willebrand factor type A domain VWA_2 PF13519.6 ELR20807.1 - 2e-08 34.9 1.1 6.5e-08 33.2 0.1 2.4 2 2 0 2 2 2 1 von Willebrand factor type A domain CCDC50_N PF15295.6 ELR20808.1 - 2.3 8.4 6.1 1.7 8.8 2.8 2.0 1 1 0 1 1 1 0 Coiled-coil domain-containing protein 50 N-terminus Pkinase_Tyr PF07714.17 ELR20809.1 - 1.8e-80 270.0 0.7 2.8e-58 197.2 0.0 2.6 2 1 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 ELR20809.1 - 1.9e-68 230.7 0.0 4.6e-52 177.0 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain PBP_like_2 PF12849.7 ELR20809.1 - 4.7e-41 141.3 13.0 3.4e-21 76.2 0.6 2.7 2 0 0 2 2 2 2 PBP superfamily domain Guanylate_cyc PF00211.20 ELR20809.1 - 2.1e-12 47.0 0.0 3.9e-12 46.2 0.0 1.3 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain TMEM154 PF15102.6 ELR20809.1 - 0.032 14.1 0.6 0.078 12.9 0.0 1.9 2 0 0 2 2 2 0 TMEM154 protein family TM140 PF14985.6 ELR20809.1 - 0.036 13.6 0.1 2 8.0 0.1 2.4 2 0 0 2 2 2 0 TM140 protein family FTA2 PF13095.6 ELR20809.1 - 0.043 13.4 0.0 0.088 12.4 0.0 1.5 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 EGF_2 PF07974.13 ELR20809.1 - 0.12 12.8 10.6 0.22 11.9 10.6 1.5 1 0 0 1 1 1 0 EGF-like domain Kinase-like PF14531.6 ELR20809.1 - 0.14 11.4 0.0 0.27 10.5 0.0 1.4 1 0 0 1 1 1 0 Kinase-like Erf4 PF10256.9 ELR20810.1 - 0.074 13.2 0.0 0.11 12.6 0.0 1.2 1 0 0 1 1 1 0 Golgin subfamily A member 7/ERF4 family HSP70 PF00012.20 ELR20811.1 - 2e-82 277.3 0.0 2.3e-82 277.1 0.0 1.0 1 0 0 1 1 1 1 Hsp70 protein NmrA PF05368.13 ELR20813.1 - 2.8e-47 161.2 0.0 4.7e-47 160.5 0.0 1.3 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 ELR20813.1 - 2.6e-14 53.5 0.5 7.5e-14 52.0 0.5 1.9 1 1 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 ELR20813.1 - 9.5e-06 25.2 0.7 1.4e-05 24.7 0.2 1.5 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 ELR20813.1 - 0.0097 15.3 0.1 0.016 14.6 0.1 1.3 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase KR PF08659.10 ELR20813.1 - 0.015 15.2 0.1 0.024 14.6 0.1 1.4 1 0 0 1 1 1 0 KR domain ORC6 PF05460.13 ELR20814.1 - 0.018 14.3 3.6 0.021 14.1 3.6 1.0 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) Peptidase_S49_N PF08496.10 ELR20814.1 - 0.4 10.7 10.3 0.91 9.6 10.3 1.5 1 1 0 1 1 1 0 Peptidase family S49 N-terminal Histone PF00125.24 ELR20814.1 - 0.5 10.7 6.7 0.59 10.5 6.7 1.1 1 0 0 1 1 1 0 Core histone H2A/H2B/H3/H4 CPSF100_C PF13299.6 ELR20814.1 - 2 8.6 6.1 2.3 8.4 6.1 1.1 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Connexin PF00029.19 ELR20814.1 - 2.3 7.9 3.5 2.5 7.8 3.5 1.1 1 0 0 1 1 1 0 Connexin p450 PF00067.22 ELR20816.1 - 6.5e-05 21.9 0.0 0.0011 17.9 0.0 2.2 1 1 1 2 2 2 2 Cytochrome P450 FragX_IP PF05994.11 ELR20817.1 - 1.9e-276 919.5 0.0 2.4e-276 919.1 0.0 1.1 1 0 0 1 1 1 1 Cytoplasmic Fragile-X interacting family DUF1394 PF07159.12 ELR20817.1 - 6.5e-10 38.8 2.7 1.2e-09 37.8 2.7 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1394) phiKZ_IP PF12699.7 ELR20817.1 - 0.13 11.4 0.0 0.22 10.6 0.0 1.3 1 0 0 1 1 1 0 phiKZ-like phage internal head proteins RFX_DNA_binding PF02257.15 ELR20819.1 - 2.8e-16 59.9 0.0 6.9e-16 58.6 0.0 1.6 1 0 0 1 1 1 1 RFX DNA-binding domain RNA_pol_3_Rpc31 PF11705.8 ELR20819.1 - 0.0096 16.2 1.4 0.0096 16.2 1.4 2.3 2 0 0 2 2 2 1 DNA-directed RNA polymerase III subunit Rpc31 Pox_D5 PF03288.16 ELR20819.1 - 0.025 15.0 0.0 0.063 13.8 0.0 1.6 1 0 0 1 1 1 0 Poxvirus D5 protein-like Pigment_DH PF06324.11 ELR20819.1 - 0.059 13.5 2.3 0.16 12.1 0.2 2.7 3 0 0 3 3 3 0 Pigment-dispersing hormone (PDH) RFX_DNA_binding PF02257.15 ELR20821.1 - 5.5e-16 59.0 0.0 7.9e-16 58.5 0.0 1.2 1 0 0 1 1 1 1 RFX DNA-binding domain TP53IP5 PF15331.6 ELR20821.1 - 0.4 10.8 3.7 0.66 10.1 3.7 1.4 1 0 0 1 1 1 0 Cellular tumour antigen p53-inducible 5 Sec62 PF03839.16 ELR20821.1 - 3.6 7.0 5.8 6.5 6.2 5.8 1.3 1 0 0 1 1 1 0 Translocation protein Sec62 Presenilin PF01080.17 ELR20821.1 - 3.9 6.2 6.2 5.9 5.5 6.2 1.3 1 0 0 1 1 1 0 Presenilin RFX_DNA_binding PF02257.15 ELR20822.1 - 8.6e-23 80.8 0.2 3e-22 79.0 0.1 1.9 2 0 0 2 2 2 1 RFX DNA-binding domain Pox_D5 PF03288.16 ELR20822.1 - 0.0021 18.5 0.0 0.0043 17.5 0.0 1.4 1 0 0 1 1 1 1 Poxvirus D5 protein-like FAM176 PF14851.6 ELR20822.1 - 0.96 9.1 4.6 2.1 8.0 0.1 2.3 2 0 0 2 2 2 0 FAM176 family BAR PF03114.18 ELR20823.1 - 6.4e-21 75.1 11.4 8.1e-21 74.8 11.4 1.1 1 0 0 1 1 1 1 BAR domain SH3_1 PF00018.28 ELR20823.1 - 1.6e-15 56.4 0.0 3.2e-15 55.5 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 ELR20823.1 - 1.8e-14 53.3 0.0 3.6e-14 52.4 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 ELR20823.1 - 4.7e-14 51.8 0.0 8.7e-14 51.0 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain BAR_3 PF16746.5 ELR20823.1 - 2.4e-10 40.5 3.7 3.8e-10 39.9 3.7 1.3 1 0 0 1 1 1 1 BAR domain of APPL family BAR_2 PF10455.9 ELR20823.1 - 7e-08 31.9 6.3 1.1e-07 31.3 6.3 1.2 1 0 0 1 1 1 1 Bin/amphiphysin/Rvs domain for vesicular trafficking SUIM_assoc PF16619.5 ELR20823.1 - 0.0011 19.0 1.2 0.033 14.3 0.0 3.2 2 1 0 2 2 2 1 Unstructured region C-term to UIM in Ataxin3 Caldesmon PF02029.15 ELR20823.1 - 0.42 9.3 9.6 0.64 8.7 9.6 1.2 1 0 0 1 1 1 0 Caldesmon AAA_18 PF13238.6 ELR20824.1 - 6.4e-29 101.1 0.0 1.1e-28 100.4 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.6 ELR20824.1 - 2.3e-06 28.1 0.4 1.1e-05 25.9 0.1 2.1 1 1 1 2 2 2 1 AAA domain AAA PF00004.29 ELR20824.1 - 1.9e-05 25.1 0.1 0.00012 22.5 0.0 2.0 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_28 PF13521.6 ELR20824.1 - 8.9e-05 22.8 0.2 0.0002 21.6 0.0 1.7 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.6 ELR20824.1 - 0.00033 20.8 0.3 0.0016 18.6 0.3 2.2 1 1 0 1 1 1 1 AAA domain NTPase_1 PF03266.15 ELR20824.1 - 0.00038 20.4 0.2 0.00081 19.3 0.0 1.7 2 0 0 2 2 2 1 NTPase ADK PF00406.22 ELR20824.1 - 0.00043 20.4 0.5 0.0061 16.7 0.5 2.2 1 1 0 1 1 1 1 Adenylate kinase ATPase PF06745.13 ELR20824.1 - 0.0023 17.3 0.8 0.0026 17.1 0.1 1.6 2 0 0 2 2 2 1 KaiC RuvB_N PF05496.12 ELR20824.1 - 0.0035 17.1 0.3 0.0072 16.1 0.0 1.6 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain SKI PF01202.22 ELR20824.1 - 0.0036 17.4 0.2 0.0064 16.6 0.2 1.4 1 1 0 1 1 1 1 Shikimate kinase Zeta_toxin PF06414.12 ELR20824.1 - 0.004 16.4 0.2 0.043 13.1 0.0 2.4 3 0 0 3 3 3 1 Zeta toxin ResIII PF04851.15 ELR20824.1 - 0.0045 17.0 0.2 0.016 15.2 0.2 1.9 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 ELR20824.1 - 0.0049 17.1 0.1 0.01 16.1 0.0 1.7 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.6 ELR20824.1 - 0.0062 16.9 0.6 0.061 13.7 0.1 2.1 2 0 0 2 2 2 1 AAA domain IstB_IS21 PF01695.17 ELR20824.1 - 0.0078 16.0 0.0 0.015 15.1 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_16 PF13191.6 ELR20824.1 - 0.0091 16.4 0.0 0.017 15.5 0.0 1.5 2 0 0 2 2 1 1 AAA ATPase domain AAA_5 PF07728.14 ELR20824.1 - 0.015 15.3 0.2 0.041 13.9 0.0 1.8 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_14 PF13173.6 ELR20824.1 - 0.019 15.0 0.2 0.15 12.1 0.0 2.1 2 0 0 2 2 2 0 AAA domain Thymidylate_kin PF02223.17 ELR20824.1 - 0.022 14.4 1.1 2.1 8.0 0.2 2.1 2 0 0 2 2 2 0 Thymidylate kinase AAA_30 PF13604.6 ELR20824.1 - 0.023 14.4 0.1 0.14 11.9 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_24 PF13479.6 ELR20824.1 - 0.026 14.2 1.1 0.065 12.9 0.3 2.0 2 2 0 2 2 2 0 AAA domain T2SSE PF00437.20 ELR20824.1 - 0.035 13.2 0.5 0.061 12.4 0.5 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein FtsK_SpoIIIE PF01580.18 ELR20824.1 - 0.042 13.2 0.6 0.21 10.9 0.1 2.0 2 0 0 2 2 2 0 FtsK/SpoIIIE family Sulfotransfer_1 PF00685.27 ELR20824.1 - 0.057 12.9 1.0 1.2 8.6 0.0 2.0 1 1 0 2 2 2 0 Sulfotransferase domain AAA_29 PF13555.6 ELR20824.1 - 0.059 13.1 0.2 0.12 12.2 0.2 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain Sigma54_activat PF00158.26 ELR20824.1 - 0.064 13.0 0.0 0.11 12.2 0.0 1.3 1 0 0 1 1 1 0 Sigma-54 interaction domain RNA_helicase PF00910.22 ELR20824.1 - 0.064 13.6 0.1 0.17 12.3 0.0 1.8 2 0 0 2 2 2 0 RNA helicase AAA_3 PF07726.11 ELR20824.1 - 0.084 12.7 0.3 0.4 10.5 0.0 2.0 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) TsaE PF02367.17 ELR20824.1 - 0.098 12.7 0.7 0.2 11.6 0.0 1.8 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE DUF2075 PF09848.9 ELR20824.1 - 0.1 11.8 3.0 0.4 9.9 2.9 2.1 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) Sacchrp_dh_NADP PF03435.18 ELR20824.1 - 0.12 12.6 0.1 0.33 11.2 0.0 1.6 2 0 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain Mg_chelatase PF01078.21 ELR20824.1 - 0.13 11.6 0.0 0.25 10.7 0.0 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI ABC_tran PF00005.27 ELR20824.1 - 0.36 11.3 1.8 0.75 10.3 1.8 1.8 1 1 0 1 1 1 0 ABC transporter CLU PF13236.6 ELR20826.1 - 2.8e-46 158.1 0.0 6e-46 157.0 0.0 1.5 1 0 0 1 1 1 1 Clustered mitochondria eIF3_p135 PF12807.7 ELR20826.1 - 9.1e-07 29.1 0.9 9.1e-07 29.1 0.9 2.3 3 0 0 3 3 3 1 Translation initiation factor eIF3 subunit 135 Fascin PF06268.13 ELR20826.1 - 2.7e-05 24.3 0.6 0.031 14.5 0.1 3.9 3 1 1 4 4 4 3 Fascin domain CRCB PF02537.15 ELR20827.1 - 1.1e-22 80.1 7.0 5.3e-17 61.9 3.3 2.8 2 0 0 2 2 2 2 CrcB-like protein, Camphor Resistance (CrcB) Ipi1_N PF12333.8 ELR20827.1 - 6.7e-08 33.1 0.0 6.7e-08 33.1 0.0 4.6 4 1 1 5 5 5 1 Rix1 complex component involved in 60S ribosome maturation ADIP PF11559.8 ELR20827.1 - 0.019 15.1 5.9 0.27 11.3 3.6 2.8 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding CDC45 PF02724.14 ELR20827.1 - 0.059 11.7 3.8 7.6 4.7 6.0 2.1 2 0 0 2 2 2 0 CDC45-like protein PepSY_2 PF13670.6 ELR20827.1 - 0.072 13.1 1.5 0.2 11.7 0.3 2.4 2 0 0 2 2 2 0 Peptidase propeptide and YPEB domain Sporozoite_P67 PF05642.11 ELR20827.1 - 0.2 9.7 2.8 0.4 8.7 2.8 1.4 1 0 0 1 1 1 0 Sporozoite P67 surface antigen RTP1_C1 PF10363.9 ELR20827.1 - 0.42 10.8 2.0 0.78 9.9 0.1 2.5 2 0 0 2 2 2 0 Required for nuclear transport of RNA pol II C-terminus 1 Frizzled PF01534.17 ELR20828.1 - 1.3e-29 103.3 13.6 1.7e-29 103.0 13.6 1.1 1 0 0 1 1 1 1 Frizzled/Smoothened family membrane region Dicty_CAR PF05462.11 ELR20828.1 - 3.1e-09 36.4 8.2 5.6e-09 35.6 8.2 1.3 1 0 0 1 1 1 1 Slime mold cyclic AMP receptor Fz PF01392.22 ELR20828.1 - 4.4e-07 30.5 0.6 1.1e-06 29.3 0.6 1.6 1 0 0 1 1 1 1 Fz domain DUF5134 PF17197.4 ELR20828.1 - 0.0053 16.7 5.2 0.013 15.4 5.2 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF5134) PDZ_3 PF17815.1 ELR20829.1 - 4.9e-53 178.9 0.0 9.2e-53 178.0 0.0 1.5 1 0 0 1 1 1 1 PDZ domain Trypsin_2 PF13365.6 ELR20829.1 - 7.1e-24 85.4 1.4 1.3e-23 84.6 1.4 1.4 1 0 0 1 1 1 1 Trypsin-like peptidase domain Trypsin PF00089.26 ELR20829.1 - 3.5e-15 56.4 0.0 5.3e-15 55.8 0.0 1.3 1 0 0 1 1 1 1 Trypsin PDZ_2 PF13180.6 ELR20829.1 - 5.2e-08 33.1 0.1 1.4e-06 28.5 0.0 2.5 2 0 0 2 2 2 1 PDZ domain PDZ PF00595.24 ELR20829.1 - 0.0027 18.0 1.2 0.019 15.3 0.0 2.8 4 0 0 4 4 4 1 PDZ domain PDZ_6 PF17820.1 ELR20829.1 - 0.0068 16.2 0.1 0.99 9.3 0.0 2.7 2 0 0 2 2 2 1 PDZ domain Peptidase_S55 PF05580.12 ELR20829.1 - 0.082 12.8 0.2 0.2 11.6 0.2 1.6 1 0 0 1 1 1 0 SpoIVB peptidase S55 CBM_20 PF00686.19 ELR20830.1 - 7e-08 32.3 0.0 1.4e-07 31.3 0.0 1.5 1 0 0 1 1 1 1 Starch binding domain DBR1 PF05011.13 ELR20831.1 - 1.9e-22 80.2 0.0 2.6e-22 79.7 0.0 1.2 1 0 0 1 1 1 1 Lariat debranching enzyme, C-terminal domain Metallophos PF00149.28 ELR20831.1 - 8.3e-06 26.4 2.8 1.5e-05 25.6 2.8 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase PGAP1 PF07819.13 ELR20833.1 - 4.2e-06 26.6 0.0 5.9e-06 26.2 0.0 1.2 1 0 0 1 1 1 1 PGAP1-like protein Abhydrolase_1 PF00561.20 ELR20833.1 - 2e-05 24.4 0.0 0.014 15.0 0.0 2.3 2 0 0 2 2 2 2 alpha/beta hydrolase fold Palm_thioest PF02089.15 ELR20833.1 - 0.016 15.1 0.0 0.023 14.6 0.0 1.3 1 0 0 1 1 1 0 Palmitoyl protein thioesterase Abhydrolase_6 PF12697.7 ELR20833.1 - 0.016 15.8 0.3 0.036 14.7 0.1 1.6 1 1 0 1 1 1 0 Alpha/beta hydrolase family DUF676 PF05057.14 ELR20833.1 - 0.032 13.7 0.0 0.051 13.1 0.0 1.2 1 0 0 1 1 1 0 Putative serine esterase (DUF676) DUF915 PF06028.11 ELR20833.1 - 0.064 12.6 0.0 0.12 11.7 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF915) LCAT PF02450.15 ELR20833.1 - 0.22 10.6 0.0 0.37 9.9 0.0 1.3 1 0 0 1 1 1 0 Lecithin:cholesterol acyltransferase IPK PF03770.16 ELR20834.1 - 2.9e-28 99.1 0.4 8e-15 55.2 0.0 2.2 1 1 1 2 2 2 2 Inositol polyphosphate kinase LRR_6 PF13516.6 ELR20836.1 - 1.1e-18 65.6 0.1 0.018 15.1 0.0 5.7 5 0 0 5 5 5 4 Leucine Rich repeat DUF4058 PF13267.6 ELR20836.1 - 0.096 12.1 0.0 0.14 11.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4058) tify PF06200.14 ELR20836.1 - 0.22 10.9 0.0 0.22 10.9 0.0 1.8 2 0 0 2 2 2 0 tify domain LRR_4 PF12799.7 ELR20837.1 - 1.6e-06 28.4 2.8 0.69 10.4 0.0 6.3 4 2 4 8 8 8 4 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 ELR20837.1 - 1.7e-06 27.6 16.8 7.7 6.9 0.1 9.2 9 0 0 9 9 9 3 Leucine Rich repeat F-box PF00646.33 ELR20837.1 - 3.3e-06 26.8 0.2 9.4e-05 22.2 0.0 3.3 3 0 0 3 3 3 1 F-box domain F-box-like PF12937.7 ELR20837.1 - 0.00026 20.8 0.1 0.0022 17.8 0.0 2.7 3 0 0 3 3 3 1 F-box-like CBM_6 PF03422.15 ELR20839.1 - 0.37 11.1 7.8 0.16 12.2 3.2 2.5 2 1 0 2 2 2 0 Carbohydrate binding module (family 6) Peptidase_S66 PF02016.15 ELR20840.1 - 1.8e-35 121.6 0.0 2.5e-35 121.2 0.0 1.2 1 0 0 1 1 1 1 LD-carboxypeptidase N-terminal domain Peptidase_S66C PF17676.1 ELR20840.1 - 3e-07 31.0 0.3 0.00059 20.4 0.0 2.3 1 1 1 2 2 2 2 LD-carboxypeptidase C-terminal domain WD40 PF00400.32 ELR20841.1 - 4.7e-45 150.7 16.8 3.8e-07 30.7 0.1 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ELR20841.1 - 4.8e-16 58.8 0.5 0.16 12.3 0.1 6.3 2 2 5 7 7 7 6 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 ELR20841.1 - 1.1e-07 31.9 0.1 0.053 13.4 0.0 3.1 2 1 1 3 3 3 3 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 ELR20841.1 - 0.00053 19.4 0.0 0.097 12.0 0.1 3.0 3 1 1 4 4 4 1 WD40-like domain Frtz PF11768.8 ELR20841.1 - 0.0037 15.7 0.1 0.6 8.4 0.0 3.1 2 1 1 3 3 3 1 WD repeat-containing and planar cell polarity effector protein Fritz PQQ_3 PF13570.6 ELR20841.1 - 0.013 15.9 0.0 4.5 7.9 0.0 3.5 3 0 0 3 3 3 0 PQQ-like domain Cytochrom_D1 PF02239.16 ELR20841.1 - 0.026 13.1 0.2 0.056 12.0 0.1 1.6 2 0 0 2 2 2 0 Cytochrome D1 heme domain DUF4598 PF15370.6 ELR20842.1 - 2.4e-09 37.7 8.8 4.2e-09 36.9 8.8 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4598) RNA_pol_Rpc4 PF05132.14 ELR20842.1 - 0.4 11.1 4.4 0.5 10.8 4.4 1.3 1 0 0 1 1 1 0 RNA polymerase III RPC4 NOA36 PF06524.12 ELR20842.1 - 1.1 8.5 12.9 1.6 8.0 12.9 1.2 1 0 0 1 1 1 0 NOA36 protein UPF0560 PF10577.9 ELR20842.1 - 3.5 6.0 6.9 4.3 5.7 6.9 1.1 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 RRN3 PF05327.11 ELR20842.1 - 5.2 5.5 9.7 6 5.3 9.7 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 NPR3 PF03666.13 ELR20842.1 - 7.1 5.3 7.4 7 5.3 7.4 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Nop14 PF04147.12 ELR20842.1 - 7.6 4.6 19.2 8.1 4.5 19.2 1.1 1 0 0 1 1 1 0 Nop14-like family Presenilin PF01080.17 ELR20842.1 - 8.3 5.1 6.6 8.5 5.0 6.6 1.1 1 0 0 1 1 1 0 Presenilin CBS PF00571.28 ELR20843.1 - 7.1e-23 80.8 1.4 2e-06 28.1 0.0 4.3 4 0 0 4 4 4 4 CBS domain adh_short PF00106.25 ELR20844.1 - 6.4e-22 78.0 0.1 3e-20 72.5 0.0 2.3 1 1 1 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 ELR20844.1 - 9.1e-17 61.4 0.0 8e-16 58.3 0.0 2.1 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase MORN PF02493.20 ELR20845.1 - 1.7e-11 43.3 19.4 5e-06 26.1 2.2 5.3 5 0 0 5 5 5 4 MORN repeat Ras PF00071.22 ELR20846.1 - 6.5e-60 201.4 0.1 7.6e-60 201.2 0.1 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR20846.1 - 3.8e-21 75.5 0.0 5.9e-21 74.9 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR20846.1 - 3.2e-09 36.5 0.0 3.4e-09 36.4 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 ELR20846.1 - 3.4e-06 26.7 0.1 1.3e-05 24.8 0.0 1.9 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 ELR20846.1 - 6.2e-05 23.0 0.9 0.084 12.8 0.0 2.4 1 1 2 3 3 3 2 RsgA GTPase MMR_HSR1 PF01926.23 ELR20846.1 - 0.00021 21.4 0.0 0.0003 20.8 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase ATP_bind_1 PF03029.17 ELR20846.1 - 0.00039 20.3 0.8 0.021 14.6 0.0 2.1 1 1 1 2 2 2 1 Conserved hypothetical ATP binding protein Septin PF00735.18 ELR20846.1 - 0.022 14.1 0.0 0.043 13.1 0.0 1.5 2 0 0 2 2 2 0 Septin DUF3494 PF11999.8 ELR20847.1 - 1e-47 162.5 8.6 1e-47 162.5 8.6 2.3 2 1 1 3 3 3 1 Protein of unknown function (DUF3494) Apyrase PF06079.11 ELR20848.1 - 2.9e-90 302.4 0.0 3.5e-90 302.2 0.0 1.0 1 0 0 1 1 1 1 Apyrase Peptidase_S28 PF05577.12 ELR20849.1 - 8e-90 301.7 0.0 9.6e-90 301.4 0.0 1.1 1 0 0 1 1 1 1 Serine carboxypeptidase S28 Abhydrolase_1 PF00561.20 ELR20849.1 - 0.00013 21.8 0.1 0.00022 21.0 0.1 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold zf-RING_2 PF13639.6 ELR20850.1 - 5e-09 36.4 4.5 9e-09 35.5 4.5 1.4 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 ELR20850.1 - 6.1e-08 32.4 4.5 1.1e-07 31.5 4.5 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 ELR20850.1 - 1e-06 28.5 3.2 1.9e-06 27.7 3.2 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 ELR20850.1 - 2.3e-06 27.3 5.8 6.1e-06 26.0 5.8 1.7 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 ELR20850.1 - 9.7e-06 25.5 1.5 3e-05 23.9 0.5 2.3 1 1 1 2 2 2 1 RING-type zinc-finger Prok-RING_4 PF14447.6 ELR20850.1 - 1e-05 25.3 5.9 3.1e-05 23.7 6.0 1.8 1 1 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 ELR20850.1 - 4e-05 23.5 4.8 8.2e-05 22.5 4.8 1.6 1 0 0 1 1 1 1 zinc-RING finger domain zf-rbx1 PF12678.7 ELR20850.1 - 7.4e-05 23.0 6.9 0.00027 21.2 6.9 2.0 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 ELR20850.1 - 0.0012 18.8 1.3 0.0026 17.8 1.3 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_11 PF17123.5 ELR20850.1 - 0.0076 16.0 1.4 0.024 14.4 1.4 1.9 1 1 0 1 1 1 1 RING-like zinc finger zf-UDP PF14569.6 ELR20850.1 - 0.011 15.9 3.9 0.035 14.2 3.9 1.9 1 0 0 1 1 1 0 Zinc-binding RING-finger zf-RING_6 PF14835.6 ELR20850.1 - 0.041 13.8 3.4 0.12 12.3 3.4 1.7 1 0 0 1 1 1 0 zf-RING of BARD1-type protein Rad50_zn_hook PF04423.14 ELR20850.1 - 0.073 12.9 0.1 0.18 11.7 0.1 1.7 1 0 0 1 1 1 0 Rad50 zinc hook motif Baculo_IE-1 PF05290.11 ELR20850.1 - 0.096 12.6 2.0 0.19 11.7 2.0 1.4 1 0 0 1 1 1 0 Baculovirus immediate-early protein (IE-0) zinc_ribbon_9 PF14369.6 ELR20850.1 - 0.25 11.7 1.9 0.96 9.8 1.9 2.1 1 0 0 1 1 1 0 zinc-ribbon zf-RING_10 PF16685.5 ELR20850.1 - 0.3 11.2 4.1 0.71 10.1 4.1 1.6 1 1 0 1 1 1 0 zinc RING finger of MSL2 zf-C3HC4_4 PF15227.6 ELR20850.1 - 0.36 11.0 9.0 0.14 12.4 5.5 2.1 2 0 0 2 2 2 0 zinc finger of C3HC4-type, RING zf-RING_4 PF14570.6 ELR20850.1 - 0.65 9.8 5.5 2 8.3 5.5 1.8 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain MOZ_SAS PF01853.18 ELR20851.1 - 3.2e-86 287.6 0.3 5.4e-86 286.8 0.3 1.4 1 0 0 1 1 1 1 MOZ/SAS family zf-MYST PF17772.1 ELR20851.1 - 2e-26 91.4 1.2 2e-26 91.4 1.2 2.3 2 0 0 2 2 2 1 MYST family zinc finger domain Tudor-knot PF11717.8 ELR20851.1 - 1.2e-21 76.3 0.3 2.8e-21 75.1 0.3 1.7 1 0 0 1 1 1 1 RNA binding activity-knot of a chromodomain Acetyltransf_1 PF00583.25 ELR20851.1 - 0.00076 19.7 0.0 0.0018 18.5 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 ELR20851.1 - 0.0039 17.6 0.0 0.0082 16.5 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain DA1-like PF12315.8 ELR20852.1 - 8.8e-15 54.6 1.9 2.4e-14 53.2 1.7 1.9 1 1 0 1 1 1 1 Protein DA1 LIM PF00412.22 ELR20852.1 - 8.5e-05 22.7 11.1 0.13 12.5 1.5 3.4 1 1 2 3 3 3 3 LIM domain DUF3090 PF11290.8 ELR20852.1 - 0.0049 16.7 0.8 1.7 8.4 0.0 2.8 3 0 0 3 3 3 2 Protein of unknown function (DUF3090) SLATT_1 PF18181.1 ELR20852.1 - 0.06 13.3 0.3 0.14 12.1 0.3 1.5 1 0 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain 1 Lipase_3 PF01764.25 ELR20853.1 - 2.2e-22 79.5 0.0 3.4e-22 78.8 0.0 1.3 1 0 0 1 1 1 1 Lipase (class 3) PhyH PF05721.13 ELR20854.1 - 6.5e-27 95.2 0.0 8e-27 94.9 0.0 1.1 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) FluMu_N PF17891.1 ELR20854.1 - 0.09 12.5 1.4 0.73 9.7 0.0 2.7 3 0 0 3 3 3 0 Mu-like prophage FluMu N-terminal domain Cupin_1 PF00190.22 ELR20855.1 - 2.1e-22 79.4 2.7 3.2e-22 78.8 2.7 1.2 1 0 0 1 1 1 1 Cupin Cupin_2 PF07883.11 ELR20855.1 - 9.5e-06 25.2 0.1 1.6e-05 24.5 0.1 1.4 1 0 0 1 1 1 1 Cupin domain adh_short PF00106.25 ELR20856.1 - 1.3e-27 96.6 0.7 1.5e-27 96.3 0.7 1.0 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ELR20856.1 - 4.2e-18 65.8 0.1 5.2e-18 65.5 0.1 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ELR20856.1 - 5.2e-07 29.7 0.0 6.4e-07 29.4 0.0 1.0 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 ELR20856.1 - 2.9e-05 23.4 0.2 3.3e-05 23.2 0.2 1.0 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein 3HCDH_N PF02737.18 ELR20856.1 - 5.7e-05 23.1 0.5 7.1e-05 22.8 0.5 1.1 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain AlaDh_PNT_C PF01262.21 ELR20856.1 - 0.00035 19.9 0.3 0.00043 19.6 0.3 1.1 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain THF_DHG_CYH_C PF02882.19 ELR20856.1 - 0.0049 16.2 0.1 0.0076 15.6 0.1 1.3 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain NAD_Gly3P_dh_N PF01210.23 ELR20856.1 - 0.028 14.4 0.0 0.032 14.2 0.0 1.2 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus UDPG_MGDP_dh_N PF03721.14 ELR20856.1 - 0.038 13.6 0.1 0.043 13.4 0.1 1.2 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain FAD_binding_3 PF01494.19 ELR20856.1 - 0.097 11.9 0.0 0.098 11.9 0.0 1.1 1 0 0 1 1 1 0 FAD binding domain CbiA PF01656.23 ELR20856.1 - 0.12 12.4 0.0 0.14 12.2 0.0 1.3 1 0 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain AdoHcyase_NAD PF00670.21 ELR20856.1 - 0.88 9.6 3.4 1.3 9.1 2.9 1.5 1 1 0 1 1 1 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain IBR PF01485.21 ELR20857.1 - 4.2e-24 84.5 48.2 2.1e-16 59.9 9.9 4.3 3 1 1 4 4 4 3 IBR domain, a half RING-finger domain zf-RING_UBOX PF13445.6 ELR20857.1 - 0.00081 19.4 3.6 0.00081 19.4 3.6 3.8 3 1 0 3 3 3 1 RING-type zinc-finger zf-RING_11 PF17123.5 ELR20857.1 - 0.041 13.6 6.4 2.9 7.7 2.5 3.0 2 0 0 2 2 2 0 RING-like zinc finger DUF5082 PF16888.5 ELR20858.1 - 0.034 14.4 2.4 0.063 13.6 2.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF5082) DUF908 PF06012.12 ELR20858.1 - 0.23 10.8 2.1 0.27 10.6 2.1 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF908) CCDC53 PF10152.9 ELR20858.1 - 4.1 7.8 7.2 5.9 7.3 7.2 1.3 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex IFT20 PF14931.6 ELR20859.1 - 0.00034 20.8 5.6 0.00034 20.8 5.6 6.3 2 2 3 5 5 5 1 Intraflagellar transport complex B, subunit 20 GAS PF13851.6 ELR20859.1 - 0.00079 18.8 20.8 0.00079 18.8 20.8 5.5 1 1 5 6 6 6 3 Growth-arrest specific micro-tubule binding HMMR_N PF15905.5 ELR20859.1 - 0.042 13.3 67.6 0.024 14.1 4.6 4.3 2 1 2 4 4 4 0 Hyaluronan mediated motility receptor N-terminal WbqC PF08889.11 ELR20859.1 - 1.1 9.1 9.7 2.6 7.9 0.5 3.0 2 1 1 3 3 3 0 WbqC-like protein family TPR_MLP1_2 PF07926.12 ELR20859.1 - 1.2 9.2 95.8 0.035 14.2 10.0 5.7 2 1 4 6 6 6 0 TPR/MLP1/MLP2-like protein HALZ PF02183.18 ELR20859.1 - 4.6 7.5 19.7 6.3 7.1 0.3 5.7 4 1 1 5 5 5 0 Homeobox associated leucine zipper DUF1664 PF07889.12 ELR20859.1 - 4.7 7.3 44.0 0.63 10.1 2.2 7.2 1 1 5 7 7 7 0 Protein of unknown function (DUF1664) YhdX PF17444.2 ELR20859.1 - 6.1 6.8 8.0 0.4 10.6 1.5 2.5 2 0 0 2 2 2 0 Uncharacterized YhdX-like Cullin PF00888.22 ELR20860.1 - 1.8e-16 59.9 5.4 5.5e-15 55.0 0.1 3.4 3 1 0 3 3 3 1 Cullin family ANAPC2 PF08672.11 ELR20860.1 - 3e-12 46.9 0.2 6.6e-12 45.8 0.2 1.6 1 0 0 1 1 1 1 Anaphase promoting complex (APC) subunit 2 PTPRCAP PF15713.5 ELR20860.1 - 0.011 16.1 0.4 0.011 16.1 0.4 2.5 2 0 0 2 2 2 0 Protein tyrosine phosphatase receptor type C-associated HTH_11 PF08279.12 ELR20860.1 - 0.072 13.0 0.0 0.49 10.4 0.0 2.4 2 0 0 2 2 2 0 HTH domain Tn7_Tnp_TnsA_C PF08721.11 ELR20860.1 - 0.74 10.5 2.8 2.1 9.0 0.1 3.0 3 0 0 3 3 3 0 TnsA endonuclease C terminal BTB PF00651.31 ELR20861.1 - 3.3e-13 49.8 0.3 6.9e-13 48.8 0.3 1.5 1 0 0 1 1 1 1 BTB/POZ domain Ank_2 PF12796.7 ELR20861.1 - 2.1e-10 41.0 0.0 3.2e-07 30.9 0.0 2.9 3 0 0 3 3 3 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 ELR20861.1 - 6.8e-09 35.8 0.0 1.3e-05 25.4 0.0 2.8 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 ELR20861.1 - 1.8e-08 34.4 0.0 0.17 12.4 0.0 3.8 3 0 0 3 3 3 3 Ankyrin repeat Ank_3 PF13606.6 ELR20861.1 - 3.5e-06 26.9 0.0 0.76 10.5 0.0 3.9 3 0 0 3 3 3 2 Ankyrin repeat DUF3342 PF11822.8 ELR20861.1 - 0.00013 22.1 1.2 0.00037 20.6 0.3 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF3342) Ank_4 PF13637.6 ELR20861.1 - 0.035 14.7 0.0 0.76 10.4 0.0 3.2 2 1 1 3 3 3 0 Ankyrin repeats (many copies) Zip PF02535.22 ELR20861.1 - 0.28 10.4 2.9 0.31 10.2 0.1 2.1 2 0 0 2 2 2 0 ZIP Zinc transporter Apt1 PF10351.9 ELR20861.1 - 1.3 7.8 10.6 1.2 7.9 2.6 2.2 2 0 0 2 2 2 0 Golgi-body localisation protein domain Ank_4 PF13637.6 ELR20862.1 - 1e-14 54.6 0.3 2.8e-11 43.7 0.1 2.2 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 ELR20862.1 - 1.4e-14 54.4 0.3 1.4e-10 41.6 0.1 1.9 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 ELR20862.1 - 4.5e-12 45.9 1.0 4.9e-06 26.7 0.1 2.9 1 1 2 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 ELR20862.1 - 4e-09 36.0 0.1 0.046 14.3 0.0 3.6 3 0 0 3 3 3 3 Ankyrin repeat Ank PF00023.30 ELR20862.1 - 3.4e-08 33.6 0.3 0.0025 18.2 0.1 3.3 3 0 0 3 3 3 2 Ankyrin repeat Peptidase_C1 PF00112.23 ELR20863.1 - 2.7e-45 155.2 3.1 5.6e-33 114.9 0.2 2.3 1 1 1 2 2 2 2 Papain family cysteine protease Inhibitor_I29 PF08246.12 ELR20863.1 - 2.5e-10 40.6 0.1 4.9e-10 39.7 0.1 1.5 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) DUF3263 PF11662.8 ELR20863.1 - 0.02 14.7 0.0 0.051 13.4 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3263) VHS PF00790.19 ELR20864.1 - 4.7e-14 52.4 0.0 1.7e-13 50.6 0.0 1.9 1 1 0 1 1 1 1 VHS domain GAT PF03127.14 ELR20864.1 - 2.1e-12 47.2 0.4 2.1e-12 47.2 0.4 2.7 2 0 0 2 2 2 1 GAT domain NOA36 PF06524.12 ELR20864.1 - 0.85 8.9 6.7 1.9 7.8 6.7 1.5 1 0 0 1 1 1 0 NOA36 protein Ribosomal_60s PF00428.19 ELR20865.1 - 1.7e-21 76.6 11.3 2.2e-21 76.2 11.3 1.2 1 0 0 1 1 1 1 60s Acidic ribosomal protein Cytomega_UL84 PF06284.11 ELR20865.1 - 0.17 10.3 0.2 0.18 10.2 0.2 1.0 1 0 0 1 1 1 0 Cytomegalovirus UL84 protein Vps26 PF03643.15 ELR20866.1 - 1.6e-121 404.5 4.6 2e-121 404.3 4.6 1.1 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 26 Arrestin_N PF00339.29 ELR20866.1 - 0.00019 21.5 2.2 0.16 12.0 0.1 2.8 2 1 1 3 3 3 2 Arrestin (or S-antigen), N-terminal domain DUF1746 PF08508.10 ELR20866.1 - 0.15 12.5 0.2 0.56 10.6 0.1 1.9 2 0 0 2 2 2 0 Fungal domain of unknown function (DUF1746) SpoU_methylase PF00588.19 ELR20867.1 - 1.3e-17 64.2 0.1 3.4e-09 37.0 0.1 2.7 1 1 1 2 2 2 2 SpoU rRNA Methylase family CH PF00307.31 ELR20868.1 - 1.8e-13 50.6 0.0 8.4e-11 42.0 0.0 2.7 2 0 0 2 2 2 2 Calponin homology (CH) domain LIM PF00412.22 ELR20868.1 - 3.2e-09 36.9 4.7 6.1e-09 36.0 4.7 1.4 1 0 0 1 1 1 1 LIM domain Corazonin PF17308.2 ELR20868.1 - 0.1 12.9 0.2 8.6 6.7 0.0 3.0 2 0 0 2 2 2 0 Pro-corazonin Mito_carr PF00153.27 ELR20869.1 - 1.5e-70 233.2 4.6 2.9e-23 81.6 0.2 3.5 3 1 0 3 3 3 3 Mitochondrial carrier protein EF-hand_7 PF13499.6 ELR20869.1 - 9.8e-18 64.4 2.8 3.4e-10 40.2 0.1 2.4 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 ELR20869.1 - 2.5e-15 55.0 0.6 2.1e-05 24.1 0.1 3.9 4 0 0 4 4 4 3 EF-hand domain EF-hand_1 PF00036.32 ELR20869.1 - 3.8e-15 54.2 7.7 0.00015 21.1 0.0 3.9 4 0 0 4 4 4 3 EF hand EF-hand_5 PF13202.6 ELR20869.1 - 9e-11 40.8 1.9 0.0095 15.4 0.2 3.5 3 0 0 3 3 3 3 EF hand EF-hand_8 PF13833.6 ELR20869.1 - 4.4e-09 36.0 2.8 3.4e-05 23.6 0.1 3.0 3 1 0 3 3 3 2 EF-hand domain pair SPARC_Ca_bdg PF10591.9 ELR20869.1 - 0.022 15.1 0.0 0.12 12.7 0.0 1.9 1 1 1 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 ELR20869.1 - 0.069 13.1 0.1 0.3 11.1 0.0 2.0 1 1 2 3 3 3 0 Cytoskeletal-regulatory complex EF hand UPF0154 PF03672.13 ELR20869.1 - 0.14 12.2 0.0 0.44 10.6 0.0 1.9 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0154) Acetyltransf_9 PF13527.7 ELR20870.1 - 2.7e-21 76.0 0.1 2.3e-20 73.0 0.0 2.1 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_17 PF17668.1 ELR20870.1 - 4.1e-05 24.4 0.0 8.1e-05 23.4 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain SCP2_2 PF13530.6 ELR20870.1 - 0.00027 21.3 0.0 0.00067 20.0 0.0 1.7 1 0 0 1 1 1 1 Sterol carrier protein domain Acetyltransf_7 PF13508.7 ELR20870.1 - 0.012 16.1 0.0 0.026 15.0 0.0 1.6 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Phage_r1t_holin PF16945.5 ELR20870.1 - 0.11 12.7 0.1 0.26 11.5 0.1 1.6 1 0 0 1 1 1 0 Putative lactococcus lactis phage r1t holin UNC-93 PF05978.16 ELR20871.1 - 3.6e-13 49.5 11.7 5.8e-12 45.6 11.7 2.9 1 1 0 1 1 1 1 Ion channel regulatory protein UNC-93 MFS_1 PF07690.16 ELR20871.1 - 4.1e-10 39.1 48.2 2.9e-06 26.4 25.2 3.0 1 1 2 3 3 3 3 Major Facilitator Superfamily p450 PF00067.22 ELR20872.1 - 1.2e-48 166.1 0.0 4.4e-48 164.2 0.0 1.7 1 1 0 1 1 1 1 Cytochrome P450 DIL PF01843.19 ELR20873.1 - 6.9e-16 58.4 1.9 6.9e-16 58.4 1.9 1.9 2 0 0 2 2 2 1 DIL domain Jnk-SapK_ap_N PF09744.9 ELR20874.1 - 0.02 15.2 5.4 0.042 14.1 5.4 1.5 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 DUF4698 PF15769.5 ELR20874.1 - 0.11 11.6 2.5 0.2 10.7 2.5 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4698) DUF812 PF05667.11 ELR20874.1 - 0.57 9.0 3.6 1 8.2 3.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF812) DUF2451 PF10474.9 ELR20875.1 - 0.052 13.3 0.0 0.073 12.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function C-terminus (DUF2451) IBR PF01485.21 ELR20876.1 - 9.3e-19 67.4 32.4 1.4e-12 47.7 7.7 4.3 3 1 1 4 4 4 2 IBR domain, a half RING-finger domain UBA PF00627.31 ELR20876.1 - 2.9e-07 30.3 0.0 3.6e-06 26.8 0.0 2.3 2 0 0 2 2 2 1 UBA/TS-N domain Prok-RING_4 PF14447.6 ELR20876.1 - 9.1e-05 22.2 6.7 9.1e-05 22.2 6.7 5.1 3 1 0 4 4 4 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 ELR20876.1 - 0.00015 21.6 6.3 0.00015 21.6 6.3 3.7 3 1 0 3 3 3 1 zinc-RING finger domain zf-C3HC4_2 PF13923.6 ELR20876.1 - 0.00034 20.4 7.7 0.00034 20.4 7.7 5.3 3 1 2 5 5 5 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 ELR20876.1 - 0.00038 20.7 6.8 0.00038 20.7 6.8 4.7 3 1 0 3 3 3 2 Ring finger domain zf-C3HC4 PF00097.25 ELR20876.1 - 0.024 14.5 7.8 0.024 14.5 7.8 4.9 3 1 1 4 4 4 0 Zinc finger, C3HC4 type (RING finger) zf-RING_4 PF14570.6 ELR20876.1 - 0.14 12.0 42.1 0.089 12.6 8.1 4.0 3 1 1 4 4 4 0 RING/Ubox like zinc-binding domain Hemerythrin PF01814.23 ELR20877.1 - 1.2e-14 55.0 3.6 2e-14 54.3 3.6 1.4 1 0 0 1 1 1 1 Hemerythrin HHE cation binding domain HDAC4_Gln PF12203.8 ELR20877.1 - 0.014 15.5 4.2 0.022 14.9 3.5 1.7 1 1 1 2 2 2 0 Glutamine rich N terminal domain of histone deacetylase 4 Phage_holin_6_1 PF09682.10 ELR20877.1 - 0.025 15.0 0.6 0.045 14.2 0.6 1.3 1 0 0 1 1 1 0 Bacteriophage holin of superfamily 6 (Holin_LLH) Cep57_CLD_2 PF14197.6 ELR20877.1 - 0.04 14.0 0.4 0.04 14.0 0.4 2.0 3 1 0 3 3 3 0 Centrosome localisation domain of PPC89 DEC-1_N PF04625.13 ELR20877.1 - 0.38 9.7 4.5 0.1 11.6 2.0 1.4 1 1 0 1 1 1 0 DEC-1 protein, N-terminal region Fzo_mitofusin PF04799.13 ELR20877.1 - 2 8.0 4.1 5.4 6.5 0.8 2.0 1 1 1 2 2 2 0 fzo-like conserved region YtxH PF12732.7 ELR20878.1 - 5.2e-07 30.1 40.6 0.036 14.6 1.9 5.7 1 1 5 6 6 6 5 YtxH-like protein DUF883 PF05957.13 ELR20878.1 - 0.00062 20.3 39.4 0.022 15.3 3.4 5.5 2 1 4 6 6 6 4 Bacterial protein of unknown function (DUF883) Apolipoprotein PF01442.18 ELR20878.1 - 0.0034 17.3 32.1 0.043 13.7 8.1 2.6 1 1 1 2 2 2 2 Apolipoprotein A1/A4/E domain ApoLp-III PF07464.11 ELR20878.1 - 0.017 15.2 3.6 0.093 12.8 0.8 2.9 1 1 1 2 2 2 0 Apolipophorin-III precursor (apoLp-III) ATP-synt_B PF00430.18 ELR20878.1 - 9 6.4 31.7 4.5 7.4 7.0 3.7 1 1 2 3 3 3 0 ATP synthase B/B' CF(0) F-box-like PF12937.7 ELR20879.1 - 7.4e-11 41.8 0.8 2.2e-10 40.2 0.0 2.0 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 ELR20879.1 - 5.7e-09 35.6 0.1 1.3e-08 34.5 0.1 1.7 1 0 0 1 1 1 1 F-box domain Ras PF00071.22 ELR20879.1 - 1.6e-07 31.0 0.0 2.3e-07 30.5 0.0 1.2 1 0 0 1 1 1 1 Ras family Methyltransf_3 PF01596.17 ELR20880.1 - 5e-74 248.1 0.0 6.1e-74 247.8 0.0 1.0 1 0 0 1 1 1 1 O-methyltransferase Methyltransf_24 PF13578.6 ELR20880.1 - 3.3e-11 44.1 0.0 5.4e-11 43.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ELR20880.1 - 0.0021 18.7 0.0 0.0048 17.6 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 ELR20880.1 - 0.012 15.5 0.0 0.017 14.9 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain CMAS PF02353.20 ELR20880.1 - 0.025 13.9 0.0 0.033 13.5 0.0 1.2 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase PCMT PF01135.19 ELR20880.1 - 0.13 11.9 0.0 0.17 11.6 0.0 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) YqeY PF09424.10 ELR20881.1 - 1.9e-34 118.8 7.3 2.3e-34 118.5 7.3 1.1 1 0 0 1 1 1 1 Yqey-like protein DUF501 PF04417.12 ELR20881.1 - 0.056 13.2 1.0 0.12 12.1 1.0 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF501) GATA PF00320.27 ELR20882.1 - 2.9e-15 55.6 4.5 6.5e-15 54.4 4.5 1.6 1 0 0 1 1 1 1 GATA zinc finger Zn-ribbon_8 PF09723.10 ELR20882.1 - 0.044 13.9 0.5 0.11 12.6 0.5 1.7 1 0 0 1 1 1 0 Zinc ribbon domain zinc_ribbon_2 PF13240.6 ELR20883.1 - 0.00032 20.3 2.4 0.00067 19.3 2.4 1.6 1 0 0 1 1 1 1 zinc-ribbon domain DZR PF12773.7 ELR20883.1 - 0.00083 19.3 0.8 0.0019 18.2 0.8 1.6 1 0 0 1 1 1 1 Double zinc ribbon zf-ribbon_3 PF13248.6 ELR20883.1 - 0.015 14.7 2.5 0.032 13.6 2.5 1.6 1 1 0 1 1 1 0 zinc-ribbon domain zf-NADH-PPase PF09297.11 ELR20883.1 - 0.037 13.7 6.3 0.66 9.7 0.6 2.6 2 0 0 2 2 2 0 NADH pyrophosphatase zinc ribbon domain Nudix_N_2 PF14803.6 ELR20883.1 - 0.055 13.4 4.4 1.3 9.0 0.4 2.4 2 0 0 2 2 2 0 Nudix N-terminal Glyco_transf_20 PF00982.21 ELR20883.1 - 0.48 9.0 2.1 0.6 8.7 2.1 1.0 1 0 0 1 1 1 0 Glycosyltransferase family 20 GFA PF04828.14 ELR20883.1 - 0.48 10.8 2.4 8.8 6.8 0.1 2.5 1 1 1 2 2 2 0 Glutathione-dependent formaldehyde-activating enzyme Keratin_2_head PF16208.5 ELR20883.1 - 0.74 9.9 38.4 0.99 9.5 38.4 1.1 1 0 0 1 1 1 0 Keratin type II head UPF0547 PF10571.9 ELR20883.1 - 2.4 8.3 8.2 21 5.3 8.2 2.1 1 1 0 1 1 1 0 Uncharacterised protein family UPF0547 MAT1 PF06391.13 ELR20883.1 - 4.5 7.0 12.4 6.2 6.6 12.4 1.1 1 0 0 1 1 1 0 CDK-activating kinase assembly factor MAT1 Collagen PF01391.18 ELR20884.1 - 4.6 7.1 7.0 0.41 10.4 0.3 2.1 2 0 0 2 2 2 0 Collagen triple helix repeat (20 copies) RFX_DNA_binding PF02257.15 ELR20886.1 - 6e-27 94.1 0.1 1.1e-26 93.2 0.1 1.4 1 0 0 1 1 1 1 RFX DNA-binding domain Pox_D5 PF03288.16 ELR20886.1 - 0.00014 22.2 0.1 0.00036 21.0 0.1 1.6 1 0 0 1 1 1 1 Poxvirus D5 protein-like DUF4961 PF16328.5 ELR20886.1 - 0.0095 15.3 0.0 0.069 12.5 0.0 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF4961) SAP130_C PF16014.5 ELR20886.1 - 2.6 7.0 8.2 4.1 6.4 8.2 1.2 1 0 0 1 1 1 0 Histone deacetylase complex subunit SAP130 C-terminus TFIIA PF03153.13 ELR20887.1 - 1.8 8.5 13.8 2.3 8.1 13.8 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit MAT1 PF06391.13 ELR20888.1 - 3.1e-17 63.1 1.2 4.2e-17 62.7 1.2 1.1 1 0 0 1 1 1 1 CDK-activating kinase assembly factor MAT1 Phyto_Pns9_10 PF05878.11 ELR20888.1 - 0.041 13.0 0.1 0.048 12.8 0.1 1.1 1 0 0 1 1 1 0 Phytoreovirus nonstructural protein Pns9/Pns10 Di19_C PF14571.6 ELR20889.1 - 0.082 13.4 0.1 0.18 12.3 0.1 1.6 1 0 0 1 1 1 0 Stress-induced protein Di19, C-terminal SRTM1 PF15872.5 ELR20890.1 - 1.4 9.1 3.7 6.6 7.0 3.7 2.1 1 1 0 1 1 1 0 Serine-rich and transmembrane domain-containing protein 1 Acetyltransf_1 PF00583.25 ELR20891.1 - 4e-08 33.5 0.0 5.3e-08 33.1 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 ELR20891.1 - 1.5e-06 28.5 0.0 2.5e-06 27.8 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.7 ELR20891.1 - 5.4e-05 23.9 0.0 7.1e-05 23.5 0.0 1.3 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 ELR20891.1 - 0.0011 18.9 0.0 0.0018 18.2 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 ELR20891.1 - 0.0032 17.4 0.0 0.0062 16.5 0.0 1.4 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_4 PF13420.7 ELR20891.1 - 0.088 12.9 0.0 0.13 12.4 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain WH1 PF00568.23 ELR20892.1 - 1.2e-18 67.0 0.0 1.9e-18 66.4 0.0 1.3 1 0 0 1 1 1 1 WH1 domain DCP1 PF06058.13 ELR20892.1 - 0.0018 18.2 0.0 0.003 17.5 0.0 1.3 1 0 0 1 1 1 1 Dcp1-like decapping family PBD PF00786.28 ELR20892.1 - 0.0054 17.1 1.0 0.0054 17.1 1.0 2.5 2 2 0 2 2 2 1 P21-Rho-binding domain OrfB_Zn_ribbon PF07282.11 ELR20893.1 - 1.6e-17 63.2 0.2 5.7e-17 61.4 0.2 2.0 1 0 0 1 1 1 1 Putative transposase DNA-binding domain Resolvase PF00239.21 ELR20893.1 - 3.4e-17 62.9 1.1 3.4e-17 62.9 1.1 2.3 2 0 0 2 2 2 1 Resolvase, N terminal domain HTH_OrfB_IS605 PF12323.8 ELR20893.1 - 1.1e-07 31.2 0.5 3.1e-07 29.8 0.5 1.7 1 0 0 1 1 1 1 Helix-turn-helix domain OrfB_IS605 PF01385.19 ELR20893.1 - 1.2e-06 28.8 0.0 1.2e-06 28.8 0.0 3.0 3 0 0 3 3 3 1 Probable transposase Dehydrin PF00257.19 ELR20893.1 - 0.0037 17.9 6.5 0.0082 16.7 6.5 1.5 1 0 0 1 1 1 1 Dehydrin HTH_17 PF12728.7 ELR20893.1 - 0.01 16.0 0.2 0.049 13.8 0.0 2.3 2 0 0 2 2 2 0 Helix-turn-helix domain C1_2 PF03107.16 ELR20893.1 - 0.11 12.8 1.1 0.25 11.7 1.1 1.6 1 0 0 1 1 1 0 C1 domain CDC45 PF02724.14 ELR20893.1 - 0.99 7.6 9.1 0.053 11.8 2.4 1.9 2 0 0 2 2 2 0 CDC45-like protein HA PF03457.14 ELR20894.1 - 3.2e-14 53.0 21.7 1.3e-06 28.6 0.3 5.3 4 1 1 5 5 5 3 Helicase associated domain zf-met PF12874.7 ELR20894.1 - 9.8e-07 29.0 5.3 2.2e-06 27.9 5.3 1.6 1 0 0 1 1 1 1 Zinc-finger of C2H2 type DUF3439 PF11921.8 ELR20894.1 - 0.041 13.8 7.3 0.094 12.7 7.3 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) zf-C2H2_jaz PF12171.8 ELR20894.1 - 0.099 13.0 7.0 0.035 14.4 4.2 1.8 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.7 ELR20894.1 - 0.12 12.8 1.7 0.4 11.0 1.7 1.9 1 0 0 1 1 1 0 C2H2 type zinc-finger (2 copies) Peptidase_S8 PF00082.22 ELR20895.1 - 2e-26 92.9 12.1 5.9e-26 91.4 8.3 2.0 1 1 1 2 2 2 2 Subtilase family TPP_enzyme_N PF02776.18 ELR20895.1 - 0.078 12.6 2.6 0.052 13.2 0.7 1.6 2 0 0 2 2 2 0 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain Redoxin PF08534.10 ELR20896.1 - 4.1e-21 75.2 0.0 5.9e-21 74.7 0.0 1.2 1 0 0 1 1 1 1 Redoxin AhpC-TSA PF00578.21 ELR20896.1 - 1.6e-10 40.9 0.0 7e-07 29.2 0.0 2.1 2 0 0 2 2 2 2 AhpC/TSA family HGTP_anticodon PF03129.20 ELR20896.1 - 0.22 11.7 0.0 0.34 11.1 0.0 1.2 1 0 0 1 1 1 0 Anticodon binding domain Pkinase PF00069.25 ELR20897.1 - 8.6e-07 28.6 0.0 1e-06 28.4 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR20897.1 - 0.04 13.2 0.1 0.046 13.0 0.1 1.0 1 0 0 1 1 1 0 Protein tyrosine kinase BUD22 PF09073.10 ELR20899.1 - 0.00039 19.9 9.2 0.00043 19.7 9.2 1.1 1 0 0 1 1 1 1 BUD22 NOA36 PF06524.12 ELR20899.1 - 0.0049 16.2 8.1 0.0059 16.0 8.1 1.2 1 0 0 1 1 1 1 NOA36 protein CDC45 PF02724.14 ELR20899.1 - 0.019 13.3 7.7 0.022 13.1 7.7 1.1 1 0 0 1 1 1 0 CDC45-like protein Polyhedrin PF00738.18 ELR20899.1 - 0.052 12.9 0.1 0.095 12.0 0.1 1.4 1 0 0 1 1 1 0 Polyhedrin CDC27 PF09507.10 ELR20899.1 - 0.059 12.7 16.8 0.073 12.4 16.8 1.1 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Nucleo_P87 PF07267.11 ELR20899.1 - 0.085 11.7 9.0 0.11 11.3 9.0 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 SKA1 PF07160.12 ELR20899.1 - 0.12 12.2 10.7 0.16 11.8 10.7 1.3 1 0 0 1 1 1 0 Spindle and kinetochore-associated protein 1 BAF1_ABF1 PF04684.13 ELR20899.1 - 0.13 11.3 9.7 0.16 11.0 9.7 1.0 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor PPP4R2 PF09184.11 ELR20899.1 - 0.25 10.9 17.7 0.37 10.3 17.7 1.2 1 0 0 1 1 1 0 PPP4R2 DUF2151 PF10221.9 ELR20899.1 - 0.43 9.1 9.4 0.52 8.8 9.4 1.0 1 0 0 1 1 1 0 Cell cycle and development regulator DNA_pol_phi PF04931.13 ELR20899.1 - 0.67 8.0 16.9 0.85 7.6 16.9 1.2 1 0 0 1 1 1 0 DNA polymerase phi RNA_pol_3_Rpc31 PF11705.8 ELR20899.1 - 0.84 9.9 19.6 1.2 9.3 19.6 1.3 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 Nop14 PF04147.12 ELR20899.1 - 1.1 7.4 19.7 1.3 7.1 19.7 1.1 1 0 0 1 1 1 0 Nop14-like family SDA1 PF05285.12 ELR20899.1 - 1.2 8.5 20.4 1.5 8.2 20.4 1.1 1 0 0 1 1 1 0 SDA1 V_ATPase_I PF01496.19 ELR20899.1 - 1.7 6.4 8.0 2.1 6.2 8.0 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Adeno_terminal PF02459.15 ELR20899.1 - 2.4 6.5 7.8 2.8 6.2 7.8 1.1 1 0 0 1 1 1 0 Adenoviral DNA terminal protein Paf1 PF03985.13 ELR20899.1 - 4.3 6.2 19.1 5.7 5.8 19.1 1.2 1 0 0 1 1 1 0 Paf1 Presenilin PF01080.17 ELR20899.1 - 4.8 5.8 10.7 5.8 5.6 10.7 1.1 1 0 0 1 1 1 0 Presenilin RR_TM4-6 PF06459.12 ELR20899.1 - 6.2 6.5 16.1 9.6 5.9 16.1 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 VIR_N PF15912.5 ELR20899.1 - 7.5 6.1 12.4 9.9 5.7 12.4 1.2 1 0 0 1 1 1 0 Virilizer, N-terminal MscS_TM PF12794.7 ELR20899.1 - 7.7 5.3 6.7 7.6 5.3 5.5 1.5 2 0 0 2 2 2 0 Mechanosensitive ion channel inner membrane domain 1 Mito_carr PF00153.27 ELR20900.1 - 2.7e-33 113.7 9.6 5.6e-16 58.2 0.6 3.1 2 1 1 3 3 3 3 Mitochondrial carrier protein Ank PF00023.30 ELR20901.1 - 0.0056 17.1 0.0 0.018 15.5 0.0 1.8 2 0 0 2 2 2 1 Ankyrin repeat Ank_2 PF12796.7 ELR20901.1 - 0.0068 17.0 0.1 0.016 15.8 0.1 1.7 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 ELR20901.1 - 0.095 13.3 0.0 0.28 11.9 0.0 1.8 2 0 0 2 2 2 0 Ankyrin repeat Ank_2 PF12796.7 ELR20902.1 - 1.8e-37 127.8 0.9 2.9e-12 47.0 0.0 3.5 2 1 2 4 4 4 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ELR20902.1 - 1.2e-34 118.3 0.7 6.1e-10 39.4 0.0 5.4 4 1 2 6 6 6 4 Ankyrin repeats (many copies) Ank_5 PF13857.6 ELR20902.1 - 3.1e-33 113.4 2.6 4.3e-07 30.1 0.0 5.9 3 3 3 6 6 6 6 Ankyrin repeats (many copies) Ank PF00023.30 ELR20902.1 - 1.9e-29 100.8 5.3 2.5e-06 27.7 0.1 6.8 7 0 0 7 7 7 5 Ankyrin repeat Ank_3 PF13606.6 ELR20902.1 - 1.5e-28 95.7 0.6 3.8e-05 23.8 0.1 7.0 7 1 1 8 8 8 5 Ankyrin repeat DUF1843 PF08898.10 ELR20902.1 - 0.2 12.2 0.6 3.4 8.2 0.0 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF1843) Ank_2 PF12796.7 ELR20903.1 - 1.1e-47 160.5 7.0 4.6e-12 46.3 0.1 4.1 1 1 4 5 5 5 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ELR20903.1 - 9e-32 109.1 1.4 1.7e-06 28.5 0.0 6.1 3 2 3 6 6 6 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 ELR20903.1 - 2e-30 101.4 5.9 0.00053 20.2 0.0 8.2 8 0 0 8 8 8 6 Ankyrin repeat Ank_5 PF13857.6 ELR20903.1 - 2.3e-25 88.3 8.4 1.5e-05 25.2 0.1 6.5 3 3 4 7 7 7 6 Ankyrin repeats (many copies) Ank PF00023.30 ELR20903.1 - 1.2e-22 79.2 14.2 0.00031 21.1 0.0 7.5 8 0 0 8 8 8 5 Ankyrin repeat Ank_2 PF12796.7 ELR20904.1 - 2.6e-54 181.7 0.2 1.1e-11 45.2 0.0 5.5 2 1 2 5 5 5 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ELR20904.1 - 1.7e-53 178.3 2.3 5.2e-11 42.9 0.0 8.1 4 1 4 8 8 8 7 Ankyrin repeats (many copies) Ank_5 PF13857.6 ELR20904.1 - 7.2e-48 160.0 6.5 4.1e-09 36.5 0.0 8.9 4 2 5 9 9 9 9 Ankyrin repeats (many copies) Ank_3 PF13606.6 ELR20904.1 - 1.5e-43 141.7 2.5 0.00011 22.3 0.1 10.6 10 0 0 10 10 10 8 Ankyrin repeat Ank PF00023.30 ELR20904.1 - 2.4e-38 128.9 8.9 7.3e-06 26.2 0.1 10.3 11 0 0 11 11 11 8 Ankyrin repeat Pkinase_Tyr PF07714.17 ELR20904.1 - 1.9e-22 79.8 0.1 7.3e-22 77.9 0.0 1.9 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.25 ELR20904.1 - 1.5e-20 73.7 0.1 2.9e-19 69.5 0.0 2.1 2 0 0 2 2 2 1 Protein kinase domain DUF1843 PF08898.10 ELR20904.1 - 0.032 14.7 3.3 9.4 6.8 0.0 3.6 4 0 0 4 4 4 0 Domain of unknown function (DUF1843) Pkinase_Tyr PF07714.17 ELR20905.1 - 4.1e-16 59.0 0.0 4.9e-16 58.8 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ELR20905.1 - 1.5e-14 54.0 0.0 1.8e-14 53.7 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain SR-25 PF10500.9 ELR20906.1 - 1.8e-06 27.7 33.9 1.8e-06 27.7 33.9 1.9 2 0 0 2 2 2 1 Nuclear RNA-splicing-associated protein ETC_C1_NDUFA5 PF04716.14 ELR20907.1 - 0.49 10.2 3.9 0.51 10.2 0.2 2.7 2 1 1 3 3 3 0 ETC complex I subunit conserved region zf-CHCC PF10276.9 ELR20908.1 - 2.2e-19 69.2 2.0 3.2e-19 68.7 2.0 1.2 1 0 0 1 1 1 1 Zinc-finger domain zf_C2H2_6 PF18450.1 ELR20908.1 - 0.53 10.0 0.1 0.53 10.0 0.1 1.9 2 0 0 2 2 2 0 Zinc Finger domain LIM PF00412.22 ELR20909.1 - 1.4e-13 50.8 8.2 1.7e-13 50.6 8.2 1.1 1 0 0 1 1 1 1 LIM domain zf-ACC PF17848.1 ELR20909.1 - 0.013 15.6 8.1 0.065 13.3 0.3 3.2 3 0 0 3 3 3 0 Acetyl-coA carboxylase zinc finger domain NinD PF17466.2 ELR20909.1 - 0.023 14.8 0.4 0.023 14.8 0.4 1.8 2 0 0 2 2 2 0 Family of unknown function Ribosomal_L37e PF01907.19 ELR20909.1 - 0.08 13.1 11.7 0.77 10.0 0.3 3.1 1 1 1 2 2 2 0 Ribosomal protein L37e HypA PF01155.19 ELR20909.1 - 0.092 12.8 5.9 1.5 8.8 5.9 2.0 1 1 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-C3HC4 PF00097.25 ELR20909.1 - 0.15 11.9 9.5 0.26 11.2 2.0 2.7 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf_UBZ PF18439.1 ELR20909.1 - 0.17 11.5 0.1 0.17 11.5 0.1 2.8 3 0 0 3 3 3 0 Ubiquitin-Binding Zinc Finger zf-C3HC4_2 PF13923.6 ELR20909.1 - 0.18 11.7 7.1 0.24 11.3 1.5 2.5 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) DZR PF12773.7 ELR20909.1 - 0.63 10.1 8.2 4.6 7.4 8.3 2.2 1 1 0 1 1 1 0 Double zinc ribbon zf-dskA_traR PF01258.17 ELR20909.1 - 0.93 9.5 10.5 11 6.0 1.6 2.8 1 1 1 2 2 2 0 Prokaryotic dksA/traR C4-type zinc finger zinc_ribbon_2 PF13240.6 ELR20909.1 - 2.6 7.9 0.1 2.6 7.9 0.1 3.1 3 0 0 3 3 3 0 zinc-ribbon domain Pyr_redox_2 PF07992.14 ELR20910.1 - 4.9e-49 167.1 0.2 8.9e-49 166.3 0.1 1.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.22 ELR20910.1 - 1.8e-26 92.6 0.5 1.8e-26 92.6 0.5 1.9 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.27 ELR20910.1 - 4.7e-15 55.9 6.1 2e-12 47.5 0.9 2.7 3 0 0 3 3 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 ELR20910.1 - 1.6e-09 37.7 0.3 5.6e-09 35.8 0.0 2.0 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 ELR20910.1 - 2.2e-09 37.0 0.1 5e-06 26.0 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 ELR20910.1 - 6.3e-09 35.0 4.5 0.00015 20.6 0.2 3.2 2 1 1 3 3 3 3 HI0933-like protein AlaDh_PNT_C PF01262.21 ELR20910.1 - 3.3e-07 29.8 1.0 0.0016 17.8 0.1 2.4 2 0 0 2 2 2 2 Alanine dehydrogenase/PNT, C-terminal domain NAD_binding_8 PF13450.6 ELR20910.1 - 2.2e-06 27.8 1.0 0.035 14.3 0.1 2.6 2 0 0 2 2 2 2 NAD(P)-binding Rossmann-like domain GIDA PF01134.22 ELR20910.1 - 4.5e-06 26.0 0.4 0.00027 20.2 0.1 2.8 3 0 0 3 3 3 1 Glucose inhibited division protein A FAD_binding_2 PF00890.24 ELR20910.1 - 3.5e-05 23.1 8.2 0.00014 21.1 0.4 3.6 4 0 0 4 4 4 1 FAD binding domain TrkA_N PF02254.18 ELR20910.1 - 0.00033 20.9 0.5 0.0083 16.4 0.1 2.5 2 0 0 2 2 2 1 TrkA-N domain Thi4 PF01946.17 ELR20910.1 - 0.00072 18.9 0.5 0.34 10.1 0.1 2.3 2 0 0 2 2 2 2 Thi4 family K_oxygenase PF13434.6 ELR20910.1 - 0.00083 18.6 0.0 0.013 14.6 0.0 2.1 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) XdhC_C PF13478.6 ELR20910.1 - 0.0015 19.0 0.1 0.35 11.4 0.0 2.6 3 0 0 3 3 2 1 XdhC Rossmann domain 3HCDH_N PF02737.18 ELR20910.1 - 0.004 17.1 1.2 0.064 13.1 0.1 2.5 3 0 0 3 3 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain DUF1188 PF06690.11 ELR20910.1 - 0.0085 15.7 0.0 0.018 14.6 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1188) Lycopene_cycl PF05834.12 ELR20910.1 - 0.0093 15.0 4.3 0.092 11.8 0.2 2.6 2 1 1 3 3 3 1 Lycopene cyclase protein FAD_binding_3 PF01494.19 ELR20910.1 - 0.014 14.6 0.3 0.43 9.8 0.0 2.3 2 0 0 2 2 2 0 FAD binding domain ApbA PF02558.16 ELR20910.1 - 0.024 14.3 0.0 0.052 13.2 0.0 1.5 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA DAO PF01266.24 ELR20910.1 - 0.052 13.1 7.5 0.65 9.5 0.2 3.4 4 0 0 4 4 4 0 FAD dependent oxidoreductase UDPG_MGDP_dh_N PF03721.14 ELR20910.1 - 0.07 12.7 0.3 0.85 9.2 0.1 2.4 2 0 0 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Bacillus_HBL PF05791.11 ELR20911.1 - 0.39 10.5 3.4 4.2 7.2 0.1 2.6 2 0 0 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) SPX PF03105.19 ELR20912.1 - 0.99 9.2 9.7 0.14 12.1 1.9 2.1 2 0 0 2 2 2 0 SPX domain Ras PF00071.22 ELR20913.1 - 2.4e-52 176.8 0.1 2.9e-52 176.6 0.1 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR20913.1 - 1.7e-18 67.0 0.0 2.3e-18 66.5 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR20913.1 - 2.6e-06 27.0 0.0 3.7e-06 26.5 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 ELR20913.1 - 1.3e-05 25.2 0.2 0.015 15.2 0.0 2.1 2 0 0 2 2 2 2 RsgA GTPase GTP_EFTU PF00009.27 ELR20913.1 - 0.00014 21.5 0.4 0.00044 19.8 0.1 1.8 1 1 0 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 ELR20913.1 - 0.014 15.5 0.0 0.022 14.9 0.0 1.4 1 0 0 1 1 1 0 50S ribosome-binding GTPase FeoB_N PF02421.18 ELR20913.1 - 0.072 12.6 0.4 0.35 10.4 0.0 2.0 3 0 0 3 3 3 0 Ferrous iron transport protein B MMR_HSR1_Xtn PF16897.5 ELR20913.1 - 0.079 13.0 0.1 0.12 12.4 0.1 1.3 1 0 0 1 1 1 0 C-terminal region of MMR_HSR1 domain G-alpha PF00503.20 ELR20913.1 - 0.09 11.9 0.4 6.7 5.8 0.1 2.1 2 0 0 2 2 2 0 G-protein alpha subunit Septin PF00735.18 ELR20913.1 - 0.13 11.5 0.0 0.18 11.1 0.0 1.2 1 0 0 1 1 1 0 Septin TolA_bind_tri PF16331.5 ELR20914.1 - 0.0038 17.3 0.7 0.0099 15.9 0.7 1.7 1 0 0 1 1 1 1 TolA binding protein trimerisation AAA_18 PF13238.6 ELR20914.1 - 0.18 12.4 0.0 0.49 10.9 0.0 1.7 1 0 0 1 1 1 0 AAA domain GREB1 PF15782.5 ELR20914.1 - 2.1 5.4 4.8 3.6 4.6 4.8 1.3 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Gaa1 PF04114.14 ELR20915.1 - 4.7e-79 266.7 3.3 6.4e-79 266.3 3.3 1.1 1 0 0 1 1 1 1 Gaa1-like, GPI transamidase component DSPc PF00782.20 ELR20916.1 - 2.2e-26 92.3 0.1 6.2e-26 90.8 0.0 1.8 2 0 0 2 2 2 1 Dual specificity phosphatase, catalytic domain Gelsolin PF00626.22 ELR20916.1 - 8.1e-07 28.9 0.4 0.003 17.4 0.0 3.3 3 0 0 3 3 3 2 Gelsolin repeat Y_phosphatase PF00102.27 ELR20916.1 - 0.1 12.2 0.0 0.19 11.3 0.0 1.3 1 0 0 1 1 1 0 Protein-tyrosine phosphatase PTPlike_phytase PF14566.6 ELR20916.1 - 0.1 12.7 0.3 0.28 11.3 0.0 1.8 2 0 0 2 2 2 0 Inositol hexakisphosphate PBP1_TM PF14812.6 ELR20916.1 - 0.16 12.3 5.2 0.48 10.8 5.2 1.7 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal WD-3 PF09765.9 ELR20917.1 - 0.031 13.6 0.7 0.065 12.6 0.7 1.5 1 0 0 1 1 1 0 WD-repeat region Snapin_Pallidin PF14712.6 ELR20917.1 - 1.4 9.3 5.0 8.6 6.9 4.2 2.5 1 1 1 2 2 2 0 Snapin/Pallidin TMF_TATA_bd PF12325.8 ELR20917.1 - 2.2 8.5 13.5 0.1 12.8 4.8 2.6 2 1 1 3 3 3 0 TATA element modulatory factor 1 TATA binding COPI_assoc PF08507.10 ELR20918.1 - 5.8e-12 45.8 6.7 9.2e-12 45.1 6.7 1.2 1 0 0 1 1 1 1 COPI associated protein DUF202 PF02656.15 ELR20918.1 - 0.78 10.2 4.3 20 5.7 0.0 2.8 2 1 0 2 2 2 0 Domain of unknown function (DUF202) DUF3096 PF11295.8 ELR20918.1 - 1 9.0 9.4 0.58 9.9 0.2 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF3096) Ank_2 PF12796.7 ELR20919.1 - 1.6e-24 86.3 3.5 1.3e-08 35.3 0.3 3.5 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ELR20919.1 - 5.2e-23 81.1 4.9 5e-08 33.3 0.1 4.5 1 1 4 5 5 5 5 Ankyrin repeats (many copies) Ank PF00023.30 ELR20919.1 - 6.7e-21 73.8 6.3 2.6e-06 27.6 0.1 5.1 5 0 0 5 5 5 4 Ankyrin repeat Ank_3 PF13606.6 ELR20919.1 - 4.5e-20 69.6 2.6 3e-06 27.1 0.1 5.2 5 0 0 5 5 5 4 Ankyrin repeat Ank_5 PF13857.6 ELR20919.1 - 4.3e-19 68.3 9.4 4.3e-07 30.1 0.1 4.3 1 1 3 4 4 4 4 Ankyrin repeats (many copies) Calpain_III PF01067.22 ELR20919.1 - 7.2e-15 55.5 0.3 5.4e-14 52.6 0.1 2.5 2 1 0 2 2 2 1 Calpain large subunit, domain III C2 PF00168.30 ELR20919.1 - 4.4e-10 39.8 0.2 1.2e-08 35.1 0.1 2.8 2 0 0 2 2 2 1 C2 domain DUF3040 PF11239.8 ELR20920.1 - 0.48 10.7 0.1 0.48 10.7 0.1 2.0 2 1 1 3 3 3 0 Protein of unknown function (DUF3040) ABC1 PF03109.16 ELR20921.1 - 1.2e-35 122.2 0.0 2.8e-35 121.0 0.0 1.6 1 0 0 1 1 1 1 ABC1 family RRM_1 PF00076.22 ELR20922.1 - 1.1e-06 28.3 0.0 2.6e-06 27.2 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 ELR20922.1 - 0.011 15.8 0.0 0.03 14.4 0.0 1.7 1 0 0 1 1 1 0 RNA recognition motif Pro_CA PF00484.19 ELR20923.1 - 3.1e-28 99.0 5.4 4.9e-28 98.4 3.4 2.3 2 1 0 2 2 2 1 Carbonic anhydrase DUF4381 PF14316.6 ELR20923.1 - 0.0083 16.4 0.9 0.014 15.6 0.3 1.6 2 0 0 2 2 2 1 Domain of unknown function (DUF4381) Aminotran_1_2 PF00155.21 ELR20924.1 - 2.3e-57 194.8 0.0 2.7e-57 194.6 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.21 ELR20924.1 - 1.4e-05 24.6 0.0 2.2e-05 23.9 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase Aminotran_5 PF00266.19 ELR20924.1 - 0.00072 18.6 0.0 0.0011 18.0 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-V DegT_DnrJ_EryC1 PF01041.17 ELR20924.1 - 0.0012 18.2 0.0 0.002 17.5 0.0 1.2 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Cys_Met_Meta_PP PF01053.20 ELR20924.1 - 0.004 15.7 0.0 0.0062 15.1 0.0 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Cbl_N2 PF02761.14 ELR20925.1 - 2e-07 31.6 0.4 1.4e-06 28.9 0.3 2.3 2 0 0 2 2 2 1 CBL proto-oncogene N-terminus, EF hand-like domain DUF4604 PF15377.6 ELR20925.1 - 0.021 15.3 23.0 0.03 14.8 23.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4604) DUF2052 PF09747.9 ELR20925.1 - 0.034 14.3 8.2 0.061 13.5 8.2 1.4 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) DUF913 PF06025.12 ELR20925.1 - 0.098 11.6 5.8 0.15 11.0 5.8 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) SLC12 PF03522.15 ELR20925.1 - 0.22 10.5 11.5 0.41 9.6 11.5 1.4 1 0 0 1 1 1 0 Solute carrier family 12 Zip PF02535.22 ELR20925.1 - 0.23 10.7 2.2 0.3 10.3 2.2 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter RP-C_C PF11800.8 ELR20925.1 - 0.31 11.1 2.8 0.57 10.2 2.8 1.4 1 0 0 1 1 1 0 Replication protein C C-terminal region Hid1 PF12722.7 ELR20925.1 - 0.73 7.9 5.8 0.97 7.5 5.8 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein CCDC106 PF15794.5 ELR20925.1 - 1.7 8.3 21.4 2.8 7.6 21.4 1.3 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 CDC45 PF02724.14 ELR20925.1 - 3.2 5.9 16.4 4.5 5.4 16.4 1.1 1 0 0 1 1 1 0 CDC45-like protein SRP-alpha_N PF04086.13 ELR20925.1 - 4.8 7.0 24.4 8.1 6.3 24.4 1.2 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal Presenilin PF01080.17 ELR20925.1 - 5 5.8 11.0 7.8 5.1 11.0 1.2 1 0 0 1 1 1 0 Presenilin Vfa1 PF08432.10 ELR20925.1 - 5.5 7.3 25.0 12 6.2 25.0 1.4 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 DUF4228 PF14009.6 ELR20925.1 - 7.1 7.0 0.0 7.1 7.0 0.0 2.6 2 1 0 2 2 1 0 Domain of unknown function (DUF4228) Treslin_N PF15292.6 ELR20926.1 - 0.0091 14.4 1.1 0.0091 14.4 1.1 1.3 2 0 0 2 2 2 1 Treslin N-terminus AP3D1 PF06375.11 ELR20926.1 - 0.79 9.9 23.1 0.1 12.8 5.8 2.2 1 1 1 2 2 2 0 AP-3 complex subunit delta-1 Ferlin_C PF16165.5 ELR20926.1 - 2.9 7.8 6.4 6.3 6.7 0.8 2.1 2 0 0 2 2 2 0 Ferlin C-terminus Presenilin PF01080.17 ELR20926.1 - 5 5.8 5.7 5.9 5.5 5.7 1.1 1 0 0 1 1 1 0 Presenilin Cnd1_N PF12922.7 ELR20926.1 - 7 6.5 8.5 1.1 9.1 0.6 2.2 2 0 0 2 2 2 0 non-SMC mitotic condensation complex subunit 1, N-term Peripla_BP_5 PF13433.6 ELR20927.1 - 8.6e-124 413.2 1.0 1.1e-123 412.8 1.0 1.0 1 0 0 1 1 1 1 Periplasmic binding protein domain Peripla_BP_6 PF13458.6 ELR20927.1 - 3.1e-57 194.8 7.6 4e-57 194.4 7.6 1.1 1 0 0 1 1 1 1 Periplasmic binding protein ANF_receptor PF01094.28 ELR20927.1 - 6.4e-07 28.8 1.0 9.8e-07 28.2 1.0 1.3 1 0 0 1 1 1 1 Receptor family ligand binding region Ribosomal_60s PF00428.19 ELR20928.1 - 6.4 7.4 13.4 0.39 11.3 1.2 2.3 2 0 0 2 2 2 0 60s Acidic ribosomal protein Arrestin_C PF02752.22 ELR20929.1 - 2.6e-05 24.7 0.1 4.4e-05 23.9 0.1 1.5 1 1 0 1 1 1 1 Arrestin (or S-antigen), C-terminal domain Arrestin_N PF00339.29 ELR20929.1 - 0.027 14.5 0.0 0.96 9.5 0.0 2.2 2 0 0 2 2 2 0 Arrestin (or S-antigen), N-terminal domain LRAT PF04970.13 ELR20930.1 - 2.2e-20 73.2 2.1 3.5e-19 69.4 2.1 2.0 1 1 0 1 1 1 1 Lecithin retinol acyltransferase Peptidase_C97 PF05903.14 ELR20930.1 - 0.01 15.7 0.0 0.012 15.4 0.0 1.2 1 0 0 1 1 1 1 PPPDE putative peptidase domain Ras PF00071.22 ELR20931.1 - 1.1e-23 83.6 0.0 1.7e-15 57.0 0.0 2.4 2 0 0 2 2 2 2 Ras family EF-hand_7 PF13499.6 ELR20931.1 - 2.1e-12 47.3 3.2 5.5e-08 33.2 1.2 2.8 1 1 2 3 3 3 2 EF-hand domain pair EF-hand_1 PF00036.32 ELR20931.1 - 1.8e-10 39.6 0.8 0.0032 16.9 0.2 3.7 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.6 ELR20931.1 - 6.8e-09 35.0 1.3 0.0044 16.8 0.1 4.6 4 0 0 4 4 4 2 EF-hand domain SH3_9 PF14604.6 ELR20931.1 - 1.4e-08 34.4 0.2 2.6e-08 33.6 0.2 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 ELR20931.1 - 3.2e-08 33.0 0.1 5.6e-08 32.3 0.1 1.4 1 0 0 1 1 1 1 SH3 domain EF-hand_8 PF13833.6 ELR20931.1 - 1.6e-07 31.1 1.9 0.00011 22.0 0.3 2.8 1 1 1 2 2 2 2 EF-hand domain pair SH3_2 PF07653.17 ELR20931.1 - 2.3e-06 27.2 0.0 4.2e-06 26.3 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain Roc PF08477.13 ELR20931.1 - 1.1e-05 25.7 0.0 0.0058 16.8 0.0 3.1 2 1 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase EF-hand_5 PF13202.6 ELR20931.1 - 2e-05 23.8 0.3 0.049 13.2 0.0 2.8 2 0 0 2 2 2 2 EF hand Rad17 PF03215.15 ELR20931.1 - 0.00011 22.2 0.0 0.0018 18.3 0.0 2.3 2 0 0 2 2 2 1 Rad17 P-loop domain MMR_HSR1 PF01926.23 ELR20931.1 - 0.0079 16.3 0.0 2.5 8.2 0.0 3.1 2 1 0 2 2 2 1 50S ribosome-binding GTPase PduV-EutP PF10662.9 ELR20931.1 - 0.026 14.3 0.0 0.087 12.6 0.0 1.8 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation Arf PF00025.21 ELR20931.1 - 0.041 13.3 0.0 1.1 8.7 0.0 2.8 2 1 0 2 2 2 0 ADP-ribosylation factor family FeoB_N PF02421.18 ELR20931.1 - 0.051 13.1 0.0 2.2 7.8 0.0 2.5 2 1 1 3 3 3 0 Ferrous iron transport protein B RsgA_GTPase PF03193.16 ELR20931.1 - 0.054 13.4 0.1 40 4.1 0.0 3.5 4 0 0 4 4 4 0 RsgA GTPase ABC_tran PF00005.27 ELR20931.1 - 0.066 13.7 0.0 4.2 7.9 0.0 2.5 2 0 0 2 2 2 0 ABC transporter AAA_14 PF13173.6 ELR20931.1 - 0.079 13.0 0.0 0.21 11.6 0.0 1.7 1 0 0 1 1 1 0 AAA domain SPARC_Ca_bdg PF10591.9 ELR20931.1 - 0.1 12.9 0.3 24 5.3 0.1 2.5 1 1 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region AAA_22 PF13401.6 ELR20931.1 - 0.16 12.3 0.2 4.3 7.6 0.0 2.9 3 1 0 3 3 3 0 AAA domain RNA_helicase PF00910.22 ELR20931.1 - 0.17 12.3 0.1 2.3 8.6 0.0 2.4 2 0 0 2 2 2 0 RNA helicase EF-hand_4 PF12763.7 ELR20931.1 - 0.26 11.3 0.6 18 5.4 0.1 3.0 1 1 2 3 3 3 0 Cytoskeletal-regulatory complex EF hand RhoGEF PF00621.20 ELR20932.1 - 4.5e-43 147.6 0.6 4.5e-43 147.6 0.6 2.0 3 0 0 3 3 3 1 RhoGEF domain PH PF00169.29 ELR20932.1 - 6.7e-10 39.4 1.5 4.9e-09 36.6 0.1 2.6 2 1 0 2 2 2 1 PH domain IQ_SEC7_PH PF16453.5 ELR20932.1 - 6.9e-05 22.8 0.6 0.00017 21.6 0.1 1.8 2 0 0 2 2 2 1 PH domain PH_13 PF16652.5 ELR20932.1 - 0.0018 18.1 4.6 0.005 16.7 0.0 2.7 2 0 0 2 2 2 1 Pleckstrin homology domain PH_9 PF15410.6 ELR20932.1 - 0.014 15.7 0.2 0.014 15.7 0.2 2.2 2 0 0 2 2 2 0 Pleckstrin homology domain IQ PF00612.27 ELR20932.1 - 0.017 14.9 0.6 0.1 12.5 0.6 2.4 1 0 0 1 1 1 0 IQ calmodulin-binding motif DUF4710 PF15828.5 ELR20932.1 - 7.5 6.7 6.3 0.75 9.9 0.4 2.4 3 0 0 3 3 3 0 Domain of unknown function (DUF4710) PRA1 PF03208.19 ELR20933.1 - 3.3e-21 75.4 1.0 4.4e-21 75.0 1.0 1.0 1 0 0 1 1 1 1 PRA1 family protein CSN8_PSD8_EIF3K PF10075.9 ELR20934.1 - 3.5e-34 117.8 0.0 5.4e-34 117.2 0.0 1.2 1 0 0 1 1 1 1 CSN8/PSMD8/EIF3K family PCI PF01399.27 ELR20934.1 - 0.00043 20.8 0.1 0.0015 19.1 0.1 2.0 1 1 0 1 1 1 1 PCI domain zf-CW PF07496.15 ELR20934.1 - 0.045 13.8 0.4 1.2 9.2 0.3 2.3 2 0 0 2 2 2 0 CW-type Zinc Finger DUF2362 PF10154.9 ELR20935.1 - 5.7e-34 117.9 4.1 3.4e-22 79.1 1.2 2.9 1 1 1 2 2 2 2 Uncharacterized conserved protein (DUF2362) Tropomyosin_1 PF12718.7 ELR20935.1 - 0.97 9.6 6.7 2.3 8.4 6.7 1.6 1 0 0 1 1 1 0 Tropomyosin like DUF2362 PF10154.9 ELR20936.1 - 1.9e-14 53.5 0.0 2.1e-14 53.4 0.0 1.0 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2362) Phage_integr_3 PF16795.5 ELR20936.1 - 0.098 12.6 0.0 0.14 12.0 0.0 1.2 1 0 0 1 1 1 0 Archaeal phage integrase BioY PF02632.14 ELR20937.1 - 4.7e-35 120.6 11.6 4.7e-35 120.6 11.6 2.0 2 0 0 2 2 2 1 BioY family ubiquitin PF00240.23 ELR20937.1 - 0.00019 21.1 0.2 0.35 10.7 0.0 2.3 2 0 0 2 2 2 2 Ubiquitin family Rad60-SLD PF11976.8 ELR20937.1 - 0.094 12.6 0.0 18 5.2 0.0 2.3 2 0 0 2 2 2 0 Ubiquitin-2 like Rad60 SUMO-like DUF4112 PF13430.6 ELR20937.1 - 0.2 11.9 3.8 0.33 11.2 0.2 2.5 2 1 0 3 3 3 0 Domain of unknown function (DUF4112) DUF2631 PF10939.8 ELR20937.1 - 1.9 8.4 5.2 12 5.8 1.1 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF2631) DUF4118 PF13493.6 ELR20937.1 - 5.1 6.9 8.7 7.4 6.4 6.8 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4118) PH PF00169.29 ELR20938.1 - 6.5e-30 103.7 0.2 4.6e-16 59.2 0.0 2.9 2 0 0 2 2 2 2 PH domain CH PF00307.31 ELR20938.1 - 1.3e-14 54.3 0.0 3.3e-14 53.0 0.0 1.7 1 0 0 1 1 1 1 Calponin homology (CH) domain PH_9 PF15410.6 ELR20938.1 - 0.0016 18.8 0.0 0.49 10.8 0.0 3.9 2 1 1 3 3 3 1 Pleckstrin homology domain Arf PF00025.21 ELR20939.1 - 5.3e-20 71.6 0.0 3.1e-19 69.1 0.0 1.9 1 1 0 1 1 1 1 ADP-ribosylation factor family F-box-like PF12937.7 ELR20939.1 - 5.8e-11 42.1 0.1 1.2e-10 41.1 0.1 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ELR20939.1 - 4.6e-08 32.7 0.1 8.5e-08 31.9 0.1 1.5 1 0 0 1 1 1 1 F-box domain Gtr1_RagA PF04670.12 ELR20939.1 - 2.5e-06 27.0 0.0 1.1e-05 25.0 0.0 2.0 2 1 0 2 2 2 1 Gtr1/RagA G protein conserved region SRPRB PF09439.10 ELR20939.1 - 0.00011 21.7 0.0 0.00029 20.3 0.0 1.7 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit Roc PF08477.13 ELR20939.1 - 0.00045 20.4 0.0 0.0032 17.7 0.0 2.4 2 1 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase F-box_4 PF15966.5 ELR20939.1 - 0.00055 19.8 0.0 0.00098 19.0 0.0 1.4 1 0 0 1 1 1 1 F-box MMR_HSR1 PF01926.23 ELR20939.1 - 0.0029 17.7 0.0 0.0082 16.2 0.0 1.8 1 1 0 1 1 1 1 50S ribosome-binding GTPase Methyltransf_25 PF13649.6 ELR20940.1 - 2.8e-10 40.8 0.0 4.4e-09 36.9 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase domain PrmA PF06325.13 ELR20940.1 - 3.9e-10 39.6 0.1 7.6e-10 38.6 0.1 1.4 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_11 PF08241.12 ELR20940.1 - 3.6e-08 33.9 0.0 3.4e-07 30.8 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain PRMT5 PF05185.16 ELR20940.1 - 9.5e-07 28.8 0.0 1.5e-06 28.2 0.0 1.2 1 0 0 1 1 1 1 PRMT5 arginine-N-methyltransferase Methyltransf_31 PF13847.6 ELR20940.1 - 1.2e-05 25.2 0.0 2.1e-05 24.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 ELR20940.1 - 1.6e-05 24.8 0.0 4.2e-05 23.4 0.0 1.7 1 1 1 2 2 2 1 Methyltransferase domain MTS PF05175.14 ELR20940.1 - 6.5e-05 22.5 0.1 0.00011 21.8 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase small domain CMAS PF02353.20 ELR20940.1 - 0.0001 21.7 0.1 0.00016 21.1 0.1 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_18 PF12847.7 ELR20940.1 - 0.00022 21.2 0.0 0.00038 20.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_24 PF13578.6 ELR20940.1 - 0.0016 19.4 0.0 0.0039 18.2 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ELR20940.1 - 0.0032 18.2 0.0 0.0099 16.6 0.0 1.9 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_9 PF08003.11 ELR20940.1 - 0.0039 16.2 0.0 0.0057 15.6 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) Met_10 PF02475.16 ELR20940.1 - 0.0045 16.8 0.0 0.0072 16.1 0.0 1.2 1 0 0 1 1 1 1 Met-10+ like-protein GidB PF02527.15 ELR20940.1 - 0.059 12.7 0.0 0.1 11.9 0.0 1.3 1 0 0 1 1 1 0 rRNA small subunit methyltransferase G Cons_hypoth95 PF03602.15 ELR20940.1 - 0.064 12.9 0.0 0.14 11.8 0.0 1.5 1 0 0 1 1 1 0 Conserved hypothetical protein 95 Methyltransf_16 PF10294.9 ELR20940.1 - 0.072 12.8 0.0 0.12 12.1 0.0 1.2 1 0 0 1 1 1 0 Lysine methyltransferase 60KD_IMP PF02096.20 ELR20941.1 - 7.6e-27 94.2 0.8 1e-26 93.8 0.8 1.1 1 0 0 1 1 1 1 60Kd inner membrane protein Tox-SHH PF15652.6 ELR20941.1 - 0.0012 19.7 0.0 0.002 19.0 0.0 1.3 1 0 0 1 1 1 1 HNH/Endo VII superfamily toxin with a SHH signature ABC2_membrane_4 PF12730.7 ELR20941.1 - 4 7.3 8.2 0.43 10.5 0.6 2.6 2 1 1 3 3 3 0 ABC-2 family transporter protein WD40 PF00400.32 ELR20942.1 - 9.3e-10 39.0 3.8 0.007 17.2 0.0 5.7 4 1 0 4 4 4 3 WD domain, G-beta repeat F-box-like PF12937.7 ELR20942.1 - 0.00016 21.5 0.0 0.00032 20.5 0.0 1.5 1 0 0 1 1 1 1 F-box-like PB1 PF00564.24 ELR20943.1 - 2.7e-08 33.6 0.0 4.5e-08 32.9 0.0 1.4 1 0 0 1 1 1 1 PB1 domain Nop25 PF09805.9 ELR20943.1 - 0.018 15.5 0.4 0.018 15.5 0.4 2.1 2 0 0 2 2 2 0 Nucleolar protein 12 (25kDa) GTP_EFTU_D3 PF03143.17 ELR20944.1 - 1.4e-12 47.9 0.0 2.1e-10 40.9 0.0 2.5 1 1 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU PF00009.27 ELR20944.1 - 9.7e-11 41.6 0.0 1.6e-10 40.9 0.0 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D2 PF03144.25 ELR20944.1 - 0.00015 22.1 0.3 0.00037 20.8 0.3 1.7 1 1 0 1 1 1 1 Elongation factor Tu domain 2 RNA_ligase PF09414.10 ELR20945.1 - 4.9e-10 39.9 0.0 6.7e-10 39.5 0.0 1.2 1 0 0 1 1 1 1 RNA ligase CoA_transf_3 PF02515.17 ELR20946.1 - 3.3e-130 434.5 0.0 3.9e-130 434.3 0.0 1.0 1 0 0 1 1 1 1 CoA-transferase family III MORN PF02493.20 ELR20947.1 - 7.3e-42 138.8 63.8 1.8e-07 30.6 0.7 9.5 9 0 0 9 9 9 9 MORN repeat FxsA PF04186.13 ELR20948.1 - 0.06 13.5 0.3 0.13 12.4 0.3 1.6 2 0 0 2 2 2 0 FxsA cytoplasmic membrane protein Di19_C PF14571.6 ELR20949.1 - 0.14 12.7 1.9 0.65 10.6 1.9 2.2 1 0 0 1 1 1 0 Stress-induced protein Di19, C-terminal RhoGAP PF00620.27 ELR20950.1 - 4.1e-43 146.8 0.4 1.1e-42 145.5 0.0 1.9 2 0 0 2 2 2 1 RhoGAP domain PH PF00169.29 ELR20950.1 - 1.2e-12 48.2 0.6 3e-12 47.0 0.6 1.7 1 0 0 1 1 1 1 PH domain SH3_1 PF00018.28 ELR20950.1 - 4.3e-07 29.4 0.0 1.1e-06 28.1 0.0 1.8 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 ELR20950.1 - 4.3e-06 26.5 0.0 1.8e-05 24.5 0.0 2.1 2 0 0 2 2 2 1 Variant SH3 domain SH3_2 PF07653.17 ELR20950.1 - 5.6e-06 25.9 0.0 1.6e-05 24.5 0.0 1.9 1 0 0 1 1 1 1 Variant SH3 domain PH_11 PF15413.6 ELR20950.1 - 0.00032 21.1 8.1 0.00047 20.5 4.2 2.9 2 1 0 2 2 2 1 Pleckstrin homology domain DUF1708 PF08101.11 ELR20950.1 - 0.0037 16.5 0.0 0.008 15.4 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1708) Lyase_8 PF02278.18 ELR20950.1 - 0.18 11.3 0.1 0.3 10.5 0.1 1.3 1 0 0 1 1 1 0 Polysaccharide lyase family 8, super-sandwich domain IclR PF01614.18 ELR20950.1 - 0.39 10.6 2.9 4.6 7.1 0.4 2.4 2 0 0 2 2 2 0 Bacterial transcriptional regulator YabA PF06156.13 ELR20950.1 - 7.5 7.3 7.6 2.5 8.8 3.9 2.0 2 0 0 2 2 2 0 Initiation control protein YabA Pkinase_Tyr PF07714.17 ELR20951.1 - 1.6e-109 365.2 0.0 1.2e-60 205.0 0.0 2.9 2 1 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 ELR20951.1 - 1.3e-96 323.1 0.0 5.4e-57 193.1 0.0 3.1 2 1 0 2 2 2 2 Protein kinase domain PBP_like_2 PF12849.7 ELR20951.1 - 1.3e-19 70.9 25.1 6.1e-10 39.2 9.1 2.4 2 0 0 2 2 2 2 PBP superfamily domain Guanylate_cyc PF00211.20 ELR20951.1 - 4.3e-13 49.3 0.0 9.7e-13 48.1 0.0 1.5 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain APH PF01636.23 ELR20951.1 - 6.3e-07 29.6 1.1 0.00037 20.5 0.0 2.8 3 0 0 3 3 3 2 Phosphotransferase enzyme family Haspin_kinase PF12330.8 ELR20951.1 - 0.00034 19.7 0.2 0.03 13.3 0.0 2.4 2 0 0 2 2 2 1 Haspin like kinase domain Kinase-like PF14531.6 ELR20951.1 - 0.00052 19.4 0.0 0.46 9.7 0.0 2.3 2 0 0 2 2 2 2 Kinase-like RIO1 PF01163.22 ELR20951.1 - 0.0036 16.9 0.4 1.3 8.6 0.1 2.4 2 0 0 2 2 2 2 RIO1 family Kdo PF06293.14 ELR20951.1 - 0.0062 15.9 0.4 3.7 6.9 0.1 2.3 2 0 0 2 2 2 2 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 ELR20951.1 - 0.01 14.7 0.0 1.9 7.2 0.0 2.2 2 0 0 2 2 2 0 Fungal protein kinase TMEM154 PF15102.6 ELR20951.1 - 0.038 13.9 0.0 0.093 12.6 0.0 1.6 1 0 0 1 1 1 0 TMEM154 protein family FTA2 PF13095.6 ELR20951.1 - 0.057 13.0 0.1 1.3 8.6 0.0 2.8 3 1 1 4 4 4 0 Kinetochore Sim4 complex subunit FTA2 EGF_2 PF07974.13 ELR20951.1 - 0.19 12.1 10.1 0.35 11.3 10.1 1.5 1 0 0 1 1 1 0 EGF-like domain EGF PF00008.27 ELR20951.1 - 0.2 12.0 5.6 0.4 11.0 5.6 1.5 1 0 0 1 1 1 0 EGF-like domain Laminin_EGF PF00053.24 ELR20951.1 - 3.6 7.8 7.1 7.4 6.8 7.1 1.4 1 0 0 1 1 1 0 Laminin EGF domain DNA_ligase_A_M PF01068.21 ELR20952.1 - 3.8e-48 163.8 0.0 5.5e-48 163.3 0.0 1.2 1 0 0 1 1 1 1 ATP dependent DNA ligase domain DNA_ligase_A_C PF04679.15 ELR20952.1 - 5e-21 75.2 0.0 1.7e-20 73.4 0.0 1.9 2 0 0 2 2 2 1 ATP dependent DNA ligase C terminal region DNA_ligase_A_N PF04675.14 ELR20952.1 - 3e-17 63.5 0.3 5.8e-17 62.6 0.3 1.5 1 0 0 1 1 1 1 DNA ligase N terminus RNA_ligase PF09414.10 ELR20952.1 - 4.4e-06 27.1 0.1 7.9e-06 26.3 0.1 1.5 1 0 0 1 1 1 1 RNA ligase TPR_12 PF13424.6 ELR20955.1 - 1.3e-25 89.5 3.7 1e-14 54.6 1.2 3.4 2 1 1 3 3 3 3 Tetratricopeptide repeat TPR_10 PF13374.6 ELR20955.1 - 2.7e-14 52.5 2.8 0.00013 21.7 0.1 4.5 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.17 ELR20955.1 - 2.1e-11 43.0 11.3 0.00049 20.0 0.1 4.9 5 0 0 5 5 4 2 Tetratricopeptide repeat TPR_1 PF00515.28 ELR20955.1 - 1.1e-09 37.7 4.1 0.0008 19.1 0.1 4.1 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_8 PF13181.6 ELR20955.1 - 2.6e-09 36.5 7.0 0.0011 19.0 0.1 4.4 4 1 1 5 5 5 2 Tetratricopeptide repeat TPR_14 PF13428.6 ELR20955.1 - 3.9e-08 33.5 5.7 0.066 14.1 0.0 4.6 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_19 PF14559.6 ELR20955.1 - 9.8e-08 32.4 10.9 0.0011 19.4 0.2 3.7 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_7 PF13176.6 ELR20955.1 - 4.6e-07 29.4 3.1 0.028 14.4 0.0 4.6 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_16 PF13432.6 ELR20955.1 - 1.3e-06 28.9 10.3 0.00077 20.1 2.1 3.9 3 1 0 3 3 2 2 Tetratricopeptide repeat ANAPC3 PF12895.7 ELR20955.1 - 6.7e-05 23.0 6.8 0.066 13.4 0.5 3.4 3 1 0 3 3 3 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_4 PF07721.14 ELR20955.1 - 0.013 16.0 2.7 7.7 7.5 0.0 3.9 3 0 0 3 3 2 0 Tetratricopeptide repeat TPR_20 PF14561.6 ELR20955.1 - 0.037 14.4 4.3 0.46 10.8 0.1 3.4 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_9 PF13371.6 ELR20955.1 - 0.04 14.1 0.5 2.2 8.5 0.0 3.0 2 1 0 2 2 2 0 Tetratricopeptide repeat HEPN_AbiV PF18728.1 ELR20955.1 - 0.055 13.6 0.4 0.15 12.2 0.4 1.7 1 0 0 1 1 1 0 AbiV T2SSS_2 PF16549.5 ELR20955.1 - 0.09 12.8 0.1 0.21 11.6 0.1 1.6 1 0 0 1 1 1 0 Type II secretion system (T2SS) pilotin, S protein CRT10 PF08728.10 ELR20955.1 - 0.12 10.5 0.3 0.16 10.1 0.3 1.1 1 0 0 1 1 1 0 CRT10 MapZ_EC1 PF18041.1 ELR20955.1 - 0.15 12.3 0.8 0.5 10.6 0.1 2.2 3 0 0 3 3 3 0 MapZ extracellular domain 1 TPR_11 PF13414.6 ELR20955.1 - 1.2 8.8 5.4 33 4.3 0.1 3.8 3 1 0 3 3 3 0 TPR repeat TPR_6 PF13174.6 ELR20955.1 - 1.4 9.7 9.1 10 7.0 0.1 4.9 6 0 0 6 6 6 0 Tetratricopeptide repeat 4HBT PF03061.22 ELR20956.1 - 3.5e-14 52.9 0.0 5.4e-14 52.3 0.0 1.3 1 0 0 1 1 1 1 Thioesterase superfamily MaoC_dehydratas PF01575.19 ELR20956.1 - 0.00045 19.8 0.1 0.002 17.7 0.0 1.8 1 1 1 2 2 2 1 MaoC like domain 4HBT_3 PF13622.6 ELR20956.1 - 0.00046 20.5 1.6 0.00057 20.2 1.6 1.1 1 0 0 1 1 1 1 Thioesterase-like superfamily 4HBT_2 PF13279.6 ELR20956.1 - 0.0085 16.6 0.0 0.0095 16.4 0.0 1.2 1 0 0 1 1 1 1 Thioesterase-like superfamily PS-DH PF14765.6 ELR20956.1 - 0.0099 15.1 0.2 0.012 14.9 0.2 1.1 1 0 0 1 1 1 1 Polyketide synthase dehydratase DUF4442 PF14539.6 ELR20956.1 - 0.031 14.4 0.1 0.039 14.1 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4442) Acyl-ACP_TE PF01643.17 ELR20956.1 - 0.091 12.0 0.0 0.12 11.7 0.0 1.1 1 0 0 1 1 1 0 Acyl-ACP thioesterase SNF2_N PF00176.23 ELR20957.1 - 1e-16 60.7 0.0 1.6e-16 60.0 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 ELR20957.1 - 4.1e-10 40.0 0.0 8.4e-10 39.0 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain SNF2_N PF00176.23 ELR20958.1 - 1.1e-34 119.7 0.0 1.4e-34 119.4 0.0 1.0 1 0 0 1 1 1 1 SNF2 family N-terminal domain ResIII PF04851.15 ELR20958.1 - 3.4e-05 23.9 0.2 0.15 12.1 0.0 2.3 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit Sedlin_N PF04628.13 ELR20959.1 - 3.9e-06 27.0 0.0 4.4e-06 26.8 0.0 1.1 1 0 0 1 1 1 1 Sedlin, N-terminal conserved region BAR PF03114.18 ELR20960.1 - 3.2e-28 99.0 9.6 3.8e-28 98.7 9.6 1.1 1 0 0 1 1 1 1 BAR domain SH3_1 PF00018.28 ELR20960.1 - 4e-08 32.7 0.0 7.3e-08 31.9 0.0 1.4 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 ELR20960.1 - 7.9e-07 28.8 0.0 1.5e-06 28.0 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 ELR20960.1 - 4.4e-06 26.3 0.0 1.1e-05 24.9 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain BAR_2 PF10455.9 ELR20960.1 - 7e-06 25.4 10.1 2.1e-05 23.8 10.1 1.6 1 1 0 1 1 1 1 Bin/amphiphysin/Rvs domain for vesicular trafficking DUF4614 PF15391.6 ELR20960.1 - 0.032 14.2 3.4 0.33 10.9 0.1 3.1 1 1 1 3 3 3 0 Domain of unknown function (DUF4614) HSP9_HSP12 PF04119.12 ELR20960.1 - 0.039 14.4 0.1 0.12 12.8 0.1 1.9 1 1 0 1 1 1 0 Heat shock protein 9/12 PMEI PF04043.15 ELR20960.1 - 0.32 11.3 3.4 0.19 12.1 1.6 1.5 2 0 0 2 2 2 0 Plant invertase/pectin methylesterase inhibitor MADF_DNA_bdg PF10545.9 ELR20960.1 - 2 8.8 7.5 0.51 10.7 3.3 2.2 2 1 1 3 3 3 0 Alcohol dehydrogenase transcription factor Myb/SANT-like ParA PF10609.9 ELR20961.1 - 2.5e-100 335.0 0.0 3e-100 334.7 0.0 1.0 1 0 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase CbiA PF01656.23 ELR20961.1 - 1.7e-10 41.0 0.0 7.4e-10 39.0 0.0 2.1 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_31 PF13614.6 ELR20961.1 - 1.3e-07 31.7 0.0 1.4e-06 28.4 0.0 2.0 1 1 0 1 1 1 1 AAA domain ArsA_ATPase PF02374.15 ELR20961.1 - 6.6e-06 25.5 0.9 0.00029 20.1 0.1 2.7 2 1 0 2 2 2 1 Anion-transporting ATPase Fer4_NifH PF00142.18 ELR20961.1 - 0.0003 20.3 0.0 0.27 10.7 0.0 2.6 2 1 0 2 2 2 2 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family AAA_26 PF13500.6 ELR20961.1 - 0.00073 19.4 0.0 0.027 14.3 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_25 PF13481.6 ELR20961.1 - 0.00089 18.9 0.0 0.0019 17.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain MipZ PF09140.11 ELR20961.1 - 0.0026 17.1 0.0 0.0077 15.5 0.0 1.8 1 1 0 1 1 1 1 ATPase MipZ RsgA_GTPase PF03193.16 ELR20961.1 - 0.0039 17.1 0.1 0.043 13.7 0.0 2.1 2 0 0 2 2 2 1 RsgA GTPase MeaB PF03308.16 ELR20961.1 - 0.007 15.4 0.1 0.011 14.7 0.1 1.2 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB CLP1_P PF16575.5 ELR20961.1 - 0.042 13.6 0.1 0.15 11.8 0.0 1.7 2 0 0 2 2 2 0 mRNA cleavage and polyadenylation factor CLP1 P-loop GTP_EFTU PF00009.27 ELR20961.1 - 0.11 12.1 0.1 0.38 10.3 0.0 1.7 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain NB-ARC PF00931.22 ELR20961.1 - 0.13 11.4 0.0 0.23 10.6 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain AAA_16 PF13191.6 ELR20961.1 - 0.14 12.5 0.1 0.3 11.5 0.1 1.8 1 1 0 1 1 1 0 AAA ATPase domain CBP_BcsQ PF06564.12 ELR20961.1 - 0.16 11.5 0.1 1 8.8 0.1 2.0 1 1 0 1 1 1 0 Cellulose biosynthesis protein BcsQ MMR_HSR1 PF01926.23 ELR20961.1 - 0.17 12.0 0.8 21 5.2 0.0 2.2 2 0 0 2 2 2 0 50S ribosome-binding GTPase DDE_Tnp_1_6 PF13751.6 ELR20961.1 - 0.39 10.9 2.1 0.33 11.2 0.2 1.8 2 0 0 2 2 2 0 Transposase DDE domain Use1 PF09753.9 ELR20962.1 - 4.7e-34 118.2 1.6 9e-34 117.3 1.6 1.5 1 1 0 1 1 1 1 Membrane fusion protein Use1 SNARE PF05739.19 ELR20962.1 - 4.2e-05 23.5 0.1 8e-05 22.6 0.1 1.4 1 0 0 1 1 1 1 SNARE domain DUF2207 PF09972.9 ELR20962.1 - 0.0012 17.7 0.3 0.0019 17.1 0.1 1.4 2 0 0 2 2 2 1 Predicted membrane protein (DUF2207) SHE3 PF17078.5 ELR20962.1 - 0.0043 16.8 3.8 0.0086 15.8 2.0 1.9 2 0 0 2 2 2 1 SWI5-dependent HO expression protein 3 GP41 PF00517.17 ELR20962.1 - 0.025 14.5 2.7 0.03 14.2 2.0 1.5 2 0 0 2 2 2 0 Retroviral envelope protein DUF1189 PF06691.11 ELR20962.1 - 0.049 13.2 1.0 0.067 12.7 1.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1189) XhlA PF10779.9 ELR20962.1 - 0.067 13.4 5.2 0.15 12.3 4.6 1.9 1 1 0 1 1 1 0 Haemolysin XhlA Pox_EPC_I2-L1 PF12575.8 ELR20962.1 - 0.16 12.2 2.5 0.5 10.6 0.6 2.2 2 0 0 2 2 2 0 Poxvirus entry protein complex L1 and I2 Tmemb_cc2 PF10267.9 ELR20962.1 - 0.18 11.0 4.8 0.31 10.1 4.8 1.3 1 0 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein DotU PF09850.9 ELR20962.1 - 0.19 11.4 0.7 0.85 9.3 0.0 2.2 2 1 0 2 2 2 0 Type VI secretion system protein DotU GAS PF13851.6 ELR20962.1 - 0.2 11.0 7.9 0.16 11.3 3.4 2.1 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding Spc7 PF08317.11 ELR20962.1 - 0.45 9.3 6.6 0.37 9.6 3.2 2.0 2 0 0 2 2 2 0 Spc7 kinetochore protein Sas6_CC PF18594.1 ELR20962.1 - 0.5 10.2 2.7 0.52 10.2 1.0 2.0 2 0 0 2 2 1 0 Sas6/XLF/XRCC4 coiled-coil domain COG2 PF06148.11 ELR20962.1 - 0.51 10.4 4.6 2.4 8.2 2.1 2.2 2 0 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 Lipoprotein_20 PF13942.6 ELR20962.1 - 0.64 9.9 4.2 0.15 11.9 0.8 1.6 2 0 0 2 2 2 0 YfhG lipoprotein FUSC PF04632.12 ELR20962.1 - 3.9 5.9 5.2 5.3 5.5 5.2 1.3 1 0 0 1 1 1 0 Fusaric acid resistance protein family MORN PF02493.20 ELR20963.1 - 8.7e-28 94.5 39.8 5.7e-08 32.2 1.2 7.2 8 0 0 8 8 8 6 MORN repeat SM-ATX PF14438.6 ELR20963.1 - 0.012 15.7 0.5 27 5.0 0.0 3.8 3 1 0 3 3 3 0 Ataxin 2 SM domain TTKRSYEDQ PF10212.9 ELR20964.1 - 2.5e-44 152.2 18.3 1.5e-26 93.5 1.7 3.5 3 1 1 4 4 4 2 Predicted coiled-coil domain-containing protein KLRAQ PF10205.9 ELR20964.1 - 4.4e-08 33.3 16.6 4.4e-08 33.3 16.6 7.1 5 2 3 8 8 8 1 Predicted coiled-coil domain-containing protein ZapB PF06005.12 ELR20964.1 - 0.0083 16.5 6.1 0.0083 16.5 6.1 7.8 5 1 2 7 7 7 3 Cell division protein ZapB Peripla_BP_6 PF13458.6 ELR20965.1 - 1.5e-12 47.9 1.2 5.9e-08 32.7 0.0 2.3 2 0 0 2 2 2 2 Periplasmic binding protein Cytochrom_D1 PF02239.16 ELR20965.1 - 0.00031 19.4 1.1 0.25 9.9 0.1 2.6 2 1 1 3 3 3 3 Cytochrome D1 heme domain DUF1513 PF07433.11 ELR20965.1 - 0.012 14.7 0.2 1.5 7.8 0.0 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF1513) PD40 PF07676.12 ELR20965.1 - 0.086 12.8 0.0 16 5.6 0.0 3.7 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat Pkinase_Tyr PF07714.17 ELR20966.1 - 4.1e-102 340.9 0.0 1.1e-61 208.4 0.0 3.2 2 1 1 3 3 3 3 Protein tyrosine kinase Pkinase PF00069.25 ELR20966.1 - 2.2e-78 263.3 0.0 1e-49 169.3 0.0 3.2 2 1 1 3 3 3 3 Protein kinase domain PBP_like_2 PF12849.7 ELR20966.1 - 5.9e-30 104.9 8.1 3.4e-16 59.8 1.1 2.3 2 0 0 2 2 2 2 PBP superfamily domain FTA2 PF13095.6 ELR20966.1 - 0.0081 15.8 0.0 0.05 13.2 0.0 2.0 1 1 1 2 2 2 1 Kinetochore Sim4 complex subunit FTA2 Kinase-like PF14531.6 ELR20966.1 - 0.12 11.6 0.0 0.27 10.5 0.0 1.5 1 0 0 1 1 1 0 Kinase-like EGF_2 PF07974.13 ELR20966.1 - 0.2 12.1 10.6 0.55 10.7 10.6 1.8 1 0 0 1 1 1 0 EGF-like domain Band_7 PF01145.25 ELR20967.1 - 1.1e-11 45.1 0.3 1.7e-11 44.5 0.3 1.2 1 1 0 1 1 1 1 SPFH domain / Band 7 family Trp_Tyr_perm PF03222.13 ELR20968.1 - 1.6e-10 40.6 22.3 1.6e-06 27.4 2.1 2.5 2 1 0 2 2 2 2 Tryptophan/tyrosine permease family DUF1772 PF08592.11 ELR20968.1 - 9.5 6.5 13.2 1.6 9.0 4.6 3.8 3 1 0 3 3 3 0 Domain of unknown function (DUF1772) Med26 PF08711.11 ELR20969.1 - 1.8e-07 31.1 0.8 4.3e-07 29.8 0.8 1.6 1 0 0 1 1 1 1 TFIIS helical bundle-like domain Pns11_12 PF17464.2 ELR20970.1 - 0.039 13.7 0.1 0.064 12.9 0.1 1.3 1 0 0 1 1 1 0 Non-structural protein 11 and 12 PT-TG PF14449.6 ELR20970.1 - 0.12 12.3 0.0 0.24 11.3 0.0 1.4 1 0 0 1 1 1 0 Pre-toxin TG Ras PF00071.22 ELR20971.1 - 2.5e-59 199.5 0.0 2.9e-59 199.3 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR20971.1 - 3.4e-32 111.2 0.0 5.3e-32 110.6 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR20971.1 - 3.8e-12 46.0 0.0 4.9e-12 45.6 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 ELR20971.1 - 6.1e-05 23.1 0.0 0.00014 21.9 0.0 1.6 1 1 1 2 2 2 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 ELR20971.1 - 8.1e-05 22.2 0.1 0.0027 17.3 0.1 2.1 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 ELR20971.1 - 0.0017 17.8 0.0 0.002 17.5 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 ELR20971.1 - 0.0019 18.1 0.2 2 8.3 0.0 2.2 1 1 0 2 2 2 2 RsgA GTPase AAA_24 PF13479.6 ELR20971.1 - 0.067 12.9 0.1 0.34 10.6 0.0 1.9 2 0 0 2 2 2 0 AAA domain SRPRB PF09439.10 ELR20971.1 - 0.096 12.1 0.0 0.14 11.5 0.0 1.4 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit Septin PF00735.18 ELR20971.1 - 0.096 11.9 0.0 0.15 11.3 0.0 1.2 1 0 0 1 1 1 0 Septin NTF2 PF02136.20 ELR20972.1 - 2.7e-24 86.0 0.1 3.1e-24 85.9 0.1 1.0 1 0 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain Mtr2 PF10429.9 ELR20972.1 - 0.0054 16.7 0.0 0.0064 16.4 0.0 1.2 1 0 0 1 1 1 1 Nuclear pore RNA shuttling protein Mtr2 SnoaL_2 PF12680.7 ELR20972.1 - 0.018 15.7 0.0 0.022 15.4 0.0 1.2 1 0 0 1 1 1 0 SnoaL-like domain CBS PF00571.28 ELR20973.1 - 1.2e-24 86.5 0.6 1.6e-05 25.3 0.0 4.3 3 1 1 4 4 4 4 CBS domain BiPBP_C PF06832.12 ELR20973.1 - 0.011 15.8 0.2 9 6.4 0.0 2.9 3 0 0 3 3 3 0 Penicillin-Binding Protein C-terminus Family HydF_tetramer PF18133.1 ELR20974.1 - 1.6e-40 137.5 0.1 4.1e-40 136.2 0.0 1.7 2 0 0 2 2 2 1 Hydrogen maturase F tetramerization domain MMR_HSR1 PF01926.23 ELR20974.1 - 7.1e-17 61.5 0.0 1.5e-16 60.5 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_N PF00350.23 ELR20974.1 - 1.2e-07 32.0 0.1 0.00075 19.6 0.1 2.6 1 1 1 2 2 2 2 Dynamin family HydF_dimer PF18128.1 ELR20974.1 - 7.3e-07 29.2 0.1 0.026 14.6 0.0 3.8 3 1 0 3 3 3 2 Hydrogen maturase F dimerization domain FeoB_N PF02421.18 ELR20974.1 - 1.9e-05 24.2 0.0 4.3e-05 23.1 0.0 1.6 1 0 0 1 1 1 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 ELR20974.1 - 0.0042 17.0 0.1 0.0089 15.9 0.1 1.6 1 0 0 1 1 1 1 RsgA GTPase AAA_18 PF13238.6 ELR20974.1 - 0.061 13.9 0.1 0.24 11.9 0.0 2.1 2 1 0 2 2 2 0 AAA domain ABC_tran PF00005.27 ELR20974.1 - 0.065 13.7 0.0 0.28 11.7 0.0 2.0 2 1 0 2 2 2 0 ABC transporter AAA_28 PF13521.6 ELR20974.1 - 0.4 10.9 1.8 5.1 7.3 0.0 2.9 3 0 0 3 3 3 0 AAA domain Radical_SAM PF04055.21 ELR20975.1 - 2e-18 67.3 0.0 3.2e-18 66.7 0.0 1.3 1 0 0 1 1 1 1 Radical SAM superfamily BATS PF06968.13 ELR20975.1 - 0.066 13.4 0.0 0.15 12.2 0.0 1.6 1 0 0 1 1 1 0 Biotin and Thiamin Synthesis associated domain IFRD PF05004.13 ELR20976.1 - 2.7e-57 194.2 4.6 3.6e-57 193.8 4.6 1.1 1 0 0 1 1 1 1 Interferon-related developmental regulator (IFRD) IFRD_C PF04836.12 ELR20976.1 - 1.1e-06 29.1 1.5 6.9e-06 26.6 0.2 2.5 2 0 0 2 2 2 1 Interferon-related protein conserved region Lipase_3 PF01764.25 ELR20977.1 - 4.6e-08 33.0 0.0 9.7e-08 32.0 0.0 1.5 1 0 0 1 1 1 1 Lipase (class 3) Type_III_YscX PF09474.10 ELR20977.1 - 0.045 14.1 0.2 0.09 13.1 0.2 1.4 1 0 0 1 1 1 0 Type III secretion system YscX (type_III_YscX) ABATE PF07336.11 ELR20977.1 - 0.2 12.3 4.0 8.5 7.1 0.9 3.0 1 1 2 3 3 3 0 Putative stress-induced transcription regulator Arm_2 PF04826.13 ELR20978.1 - 3.6e-06 26.6 1.0 5.8e-05 22.7 1.0 2.5 1 1 1 2 2 2 1 Armadillo-like KAP PF05804.12 ELR20978.1 - 1.8e-05 23.1 0.1 2.4e-05 22.7 0.1 1.1 1 0 0 1 1 1 1 Kinesin-associated protein (KAP) Arm PF00514.23 ELR20978.1 - 2.2e-05 24.3 0.5 6.5 6.9 0.0 4.1 3 0 0 3 3 3 3 Armadillo/beta-catenin-like repeat DUF4381 PF14316.6 ELR20978.1 - 0.00046 20.4 0.8 0.0032 17.7 0.2 2.5 2 0 0 2 2 2 1 Domain of unknown function (DUF4381) Ric8 PF10165.9 ELR20978.1 - 0.00051 19.2 0.8 0.0015 17.7 0.8 1.7 1 1 0 1 1 1 1 Guanine nucleotide exchange factor synembryn SbcD_C PF12320.8 ELR20978.1 - 0.035 14.4 0.0 0.15 12.4 0.0 2.1 1 0 0 1 1 1 0 Type 5 capsule protein repressor C-terminal domain TFCD_C PF12612.8 ELR20978.1 - 0.074 12.9 3.2 0.44 10.4 0.1 2.7 1 1 1 2 2 2 0 Tubulin folding cofactor D C terminal V-ATPase_H_C PF11698.8 ELR20978.1 - 0.094 12.8 0.1 2.7 8.1 0.1 2.6 1 1 1 2 2 2 0 V-ATPase subunit H Kelch_3 PF13415.6 ELR20979.1 - 4.7e-15 55.4 1.2 3.4e-09 36.7 0.0 2.5 2 1 0 2 2 2 2 Galactose oxidase, central domain Kelch_4 PF13418.6 ELR20979.1 - 4.1e-11 42.7 2.8 1.3e-08 34.7 0.1 2.6 3 0 0 3 3 3 2 Galactose oxidase, central domain Kelch_1 PF01344.25 ELR20979.1 - 1.9e-09 37.0 0.3 5.8e-05 22.6 0.0 2.3 2 0 0 2 2 2 2 Kelch motif Kelch_5 PF13854.6 ELR20979.1 - 5.5e-08 32.6 0.7 8.1e-05 22.5 0.0 2.5 2 0 0 2 2 2 2 Kelch motif Kelch_2 PF07646.15 ELR20979.1 - 1.4e-05 24.8 0.5 0.00095 19.1 0.1 2.4 2 0 0 2 2 2 1 Kelch motif Kelch_6 PF13964.6 ELR20979.1 - 4.5e-05 23.6 0.1 0.25 11.7 0.0 2.4 2 0 0 2 2 2 2 Kelch motif Exo_endo_phos PF03372.23 ELR20980.1 - 6.5e-08 32.4 0.0 2.9e-07 30.3 0.0 2.1 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family HEAT PF02985.22 ELR20981.1 - 2.3e-22 77.2 8.0 4.3e-05 23.4 0.0 11.7 11 0 0 11 11 10 4 HEAT repeat HEAT_EZ PF13513.6 ELR20981.1 - 2.6e-22 78.9 0.9 1.3e-07 31.9 0.1 8.8 8 1 1 9 9 8 4 HEAT-like repeat HEAT_2 PF13646.6 ELR20981.1 - 9.7e-19 67.6 6.9 8.7e-06 26.1 0.0 9.5 5 3 3 9 9 9 2 HEAT repeats Vac14_Fab1_bd PF12755.7 ELR20981.1 - 8.6e-12 45.5 0.0 0.007 16.9 0.0 5.8 4 1 1 5 5 5 3 Vacuolar 14 Fab1-binding region Cnd1 PF12717.7 ELR20981.1 - 1.4e-09 38.2 2.2 9.4e-08 32.3 0.0 4.9 6 2 0 6 6 6 1 non-SMC mitotic condensation complex subunit 1 ParcG PF10274.9 ELR20981.1 - 1.8e-07 31.5 1.1 0.0052 16.9 0.1 4.9 5 1 1 6 6 6 2 Parkin co-regulated protein CLASP_N PF12348.8 ELR20981.1 - 5.4e-07 29.4 0.0 0.41 10.2 0.0 5.2 4 2 2 6 6 6 2 CLASP N terminal IBN_N PF03810.19 ELR20981.1 - 1.1e-05 25.3 1.4 0.00019 21.2 0.5 2.9 2 0 0 2 2 2 1 Importin-beta N-terminal domain RIX1 PF08167.12 ELR20981.1 - 1.4e-05 25.0 0.0 0.63 9.8 0.0 4.5 4 0 0 4 4 4 1 rRNA processing/ribosome biogenesis Arm PF00514.23 ELR20981.1 - 2.2e-05 24.3 3.3 2.2 8.4 0.0 7.5 9 0 0 9 9 8 1 Armadillo/beta-catenin-like repeat MMS19_C PF12460.8 ELR20981.1 - 0.00029 20.1 1.4 1.2 8.1 0.2 4.2 4 1 0 4 4 4 2 RNAPII transcription regulator C-terminal Adaptin_N PF01602.20 ELR20981.1 - 0.00043 19.0 0.3 0.024 13.2 0.1 3.3 3 0 0 3 3 3 1 Adaptin N terminal region UME PF08064.13 ELR20981.1 - 0.00043 20.2 0.2 7.4 6.5 0.0 5.0 5 0 0 5 5 5 1 UME (NUC010) domain NUC173 PF08161.12 ELR20981.1 - 0.0047 16.6 0.2 3.7 7.1 0.0 4.1 4 0 0 4 4 4 1 NUC173 domain BP28CT PF08146.12 ELR20981.1 - 0.039 13.8 0.1 2.2 8.1 0.0 3.8 5 1 0 5 5 4 0 BP28CT (NUC211) domain Cnd3 PF12719.7 ELR20981.1 - 0.095 11.9 3.1 1.7 7.7 0.1 3.8 4 0 0 4 4 4 0 Nuclear condensing complex subunits, C-term domain Importin_rep_4 PF18808.1 ELR20981.1 - 0.17 12.2 0.3 2.8 8.3 0.1 3.0 2 0 0 2 2 2 0 Importin repeat RTP1_C1 PF10363.9 ELR20981.1 - 0.3 11.3 1.2 74 3.6 0.0 4.6 5 1 1 6 6 6 0 Required for nuclear transport of RNA pol II C-terminus 1 V-ATPase_H_N PF03224.14 ELR20981.1 - 0.32 10.3 0.9 8.7 5.5 0.0 3.4 4 1 0 5 5 5 0 V-ATPase subunit H CENP-B_dimeris PF09026.10 ELR20981.1 - 2.6 8.5 5.7 0.21 12.0 0.6 1.8 2 0 0 2 2 1 0 Centromere protein B dimerisation domain BATS PF06968.13 ELR20982.1 - 2e-26 92.0 0.0 4.9e-26 90.7 0.0 1.7 1 0 0 1 1 1 1 Biotin and Thiamin Synthesis associated domain Radical_SAM PF04055.21 ELR20982.1 - 1e-10 42.2 0.1 4.1e-10 40.3 0.1 1.8 2 0 0 2 2 2 1 Radical SAM superfamily WH1 PF00568.23 ELR20983.1 - 6.8e-19 67.8 0.2 1.3e-18 66.9 0.2 1.4 1 0 0 1 1 1 1 WH1 domain CAF-1_p150 PF11600.8 ELR20983.1 - 0.0029 17.3 26.3 0.0029 17.3 26.3 6.3 3 2 3 6 6 6 1 Chromatin assembly factor 1 complex p150 subunit, N-terminal PWI PF01480.17 ELR20984.1 - 8.5e-15 54.8 2.5 1.2e-14 54.4 1.4 1.8 2 0 0 2 2 2 1 PWI domain RRM_1 PF00076.22 ELR20984.1 - 3.5e-11 42.8 0.0 6.3e-11 41.9 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Androgen_recep PF02166.16 ELR20984.1 - 0.97 8.2 20.6 1.8 7.3 20.6 1.3 1 0 0 1 1 1 0 Androgen receptor MoaC PF01967.21 ELR20985.1 - 8e-40 136.1 0.4 4.1e-39 133.8 0.2 2.0 2 0 0 2 2 2 1 MoaC family Mob_synth_C PF06463.13 ELR20985.1 - 2.1e-38 131.1 0.0 4.2e-38 130.2 0.0 1.5 1 0 0 1 1 1 1 Molybdenum Cofactor Synthesis C Radical_SAM PF04055.21 ELR20985.1 - 1.5e-33 116.6 0.1 2.5e-33 115.8 0.1 1.4 1 0 0 1 1 1 1 Radical SAM superfamily Fer4_12 PF13353.6 ELR20985.1 - 2e-08 34.6 0.0 5.3e-08 33.2 0.0 1.7 1 1 0 1 1 1 1 4Fe-4S single cluster domain Fer4_14 PF13394.6 ELR20985.1 - 0.00023 21.3 0.1 0.0016 18.6 0.0 2.3 3 1 0 3 3 3 1 4Fe-4S single cluster domain TetR_C_12 PF16914.5 ELR20985.1 - 0.11 12.6 0.7 0.67 10.1 0.1 2.4 2 0 0 2 2 2 0 Bacterial transcriptional repressor C-terminal ThiS PF02597.20 ELR20986.1 - 2.5e-16 60.1 0.0 2.8e-16 59.9 0.0 1.0 1 0 0 1 1 1 1 ThiS family Stk19 PF10494.9 ELR20987.1 - 2.6e-35 122.3 0.1 4.5e-35 121.5 0.1 1.3 1 0 0 1 1 1 1 Serine-threonine protein kinase 19 PEX11 PF05648.14 ELR20988.1 - 1.3e-33 116.3 0.8 3.5e-33 115.0 0.8 1.7 1 0 0 1 1 1 1 Peroxisomal biogenesis factor 11 (PEX11) SAD_SRA PF02182.17 ELR20988.1 - 9.4e-15 54.6 0.0 2.5e-14 53.3 0.0 1.7 1 0 0 1 1 1 1 SAD/SRA domain PHD PF00628.29 ELR20988.1 - 9.2e-12 44.7 5.4 2.1e-11 43.5 5.4 1.7 1 0 0 1 1 1 1 PHD-finger PHD_2 PF13831.6 ELR20988.1 - 0.048 13.2 1.4 0.099 12.2 1.4 1.5 1 0 0 1 1 1 0 PHD-finger zinc_ribbon_10 PF10058.9 ELR20988.1 - 0.77 9.5 5.4 0.81 9.5 3.9 1.9 2 0 0 2 2 2 0 Predicted integral membrane zinc-ribbon metal-binding protein LRR_6 PF13516.6 ELR20989.1 - 2.2e-12 45.9 0.3 0.21 11.8 0.0 7.6 8 0 0 8 8 8 4 Leucine Rich repeat LRR_4 PF12799.7 ELR20989.1 - 0.0012 19.2 0.7 10 6.7 0.0 4.3 3 1 1 4 4 4 2 Leucine Rich repeats (2 copies) SpoU_sub_bind PF08032.12 ELR20989.1 - 0.033 14.5 0.0 1.3 9.4 0.0 3.2 3 0 0 3 3 3 0 RNA 2'-O ribose methyltransferase substrate binding Vhr1 PF04001.13 ELR20989.1 - 0.11 12.8 2.5 0.22 11.8 2.5 1.4 1 0 0 1 1 1 0 Transcription factor Vhr1 PSS PF03034.15 ELR20990.1 - 6.2e-42 144.2 0.2 1.7e-40 139.5 0.0 2.2 2 0 0 2 2 2 2 Phosphatidyl serine synthase CN_hydrolase PF00795.22 ELR20991.1 - 1.2e-11 44.4 0.0 1.9e-11 43.8 0.0 1.2 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase DUF1995 PF09353.10 ELR20991.1 - 0.15 12.1 0.0 0.23 11.5 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1995) NDT80_PhoG PF05224.12 ELR20992.1 - 0.03 14.5 0.2 0.035 14.3 0.2 1.2 1 0 0 1 1 1 0 NDT80 / PhoG like DNA-binding family CLLAC PF15675.5 ELR20993.1 - 0.093 12.3 4.2 0.17 11.5 4.2 1.3 1 0 0 1 1 1 0 CLLAC-motif containing domain Lipase_GDSL PF00657.22 ELR20994.1 - 4.9e-10 39.7 0.0 3.9e-09 36.8 0.0 2.4 2 1 0 2 2 2 1 GDSL-like Lipase/Acylhydrolase Acetyltransf_9 PF13527.7 ELR20995.1 - 1.3e-21 77.0 0.0 2.5e-21 76.1 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 ELR20995.1 - 2.3e-09 37.5 0.1 6.9e-09 36.0 0.0 1.8 2 0 0 2 2 2 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 ELR20995.1 - 3.3e-06 27.4 0.0 7.3e-06 26.3 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 ELR20995.1 - 5e-05 23.3 0.0 0.00012 22.1 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 ELR20995.1 - 0.002 18.0 0.0 0.004 17.1 0.0 1.5 1 0 0 1 1 1 1 FR47-like protein Pkinase PF00069.25 ELR20996.1 - 1.8e-35 122.6 0.0 7.8e-35 120.5 0.0 2.1 2 0 0 2 2 2 1 Protein kinase domain HATPase_c PF02518.26 ELR20996.1 - 1.5e-26 93.1 0.8 4.7e-24 85.0 0.8 2.8 1 1 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase AAA_16 PF13191.6 ELR20996.1 - 1.2e-25 90.8 0.0 4.1e-25 89.1 0.0 2.0 1 0 0 1 1 1 1 AAA ATPase domain Response_reg PF00072.24 ELR20996.1 - 1.7e-22 79.7 0.0 7.7e-22 77.6 0.0 2.3 2 0 0 2 2 1 1 Response regulator receiver domain Pkinase_Tyr PF07714.17 ELR20996.1 - 2.6e-18 66.2 0.0 5.3e-18 65.2 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase HisKA PF00512.25 ELR20996.1 - 3e-18 65.6 0.1 1.3e-17 63.5 0.1 2.2 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain GAF_2 PF13185.6 ELR20996.1 - 4.3e-07 30.3 0.0 2e-06 28.2 0.0 2.2 2 0 0 2 2 2 1 GAF domain GAF PF01590.26 ELR20996.1 - 1.3e-05 25.9 0.0 3.6e-05 24.4 0.0 1.8 1 0 0 1 1 1 1 GAF domain GAF_3 PF13492.6 ELR20996.1 - 0.00022 21.6 0.0 0.00087 19.6 0.0 2.1 1 0 0 1 1 1 1 GAF domain Kinase-like PF14531.6 ELR20996.1 - 0.0014 18.0 0.0 0.0026 17.1 0.0 1.4 1 0 0 1 1 1 1 Kinase-like RsgA_GTPase PF03193.16 ELR20996.1 - 0.013 15.4 0.0 0.034 14.1 0.0 1.6 1 0 0 1 1 1 0 RsgA GTPase AAA_22 PF13401.6 ELR20996.1 - 0.063 13.5 0.0 0.36 11.1 0.0 2.3 1 1 0 1 1 1 0 AAA domain Pkinase PF00069.25 ELR20997.1 - 4.4e-36 124.6 0.0 5.9e-36 124.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR20997.1 - 2.7e-19 69.5 0.0 3.2e-19 69.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Asp PF00026.23 ELR20997.1 - 5.8e-10 39.1 0.0 8.2e-10 38.6 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_C PF14541.6 ELR20997.1 - 4e-07 30.0 0.0 6.4e-07 29.3 0.0 1.3 1 0 0 1 1 1 1 Xylanase inhibitor C-terminal Kinase-like PF14531.6 ELR20997.1 - 0.0002 20.8 0.0 0.00031 20.2 0.0 1.2 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 ELR20997.1 - 0.15 12.0 0.0 0.63 9.9 0.0 1.9 1 1 1 2 2 2 0 Phosphotransferase enzyme family Asp PF00026.23 ELR20998.1 - 4.4e-15 55.9 0.0 5.9e-15 55.5 0.0 1.2 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 ELR20998.1 - 0.0024 18.2 1.8 0.019 15.2 0.5 2.4 1 1 1 2 2 2 1 Xylanase inhibitor N-terminal C2 PF00168.30 ELR20999.1 - 2e-06 28.0 0.0 4e-06 27.0 0.0 1.5 1 0 0 1 1 1 1 C2 domain C2-C2_1 PF11618.8 ELR20999.1 - 0.05 13.7 0.0 0.12 12.5 0.0 1.6 1 0 0 1 1 1 0 First C2 domain of RPGR-interacting protein 1 Synaptobrevin PF00957.21 ELR21002.1 - 2.4e-29 101.0 2.5 2.4e-29 101.0 2.5 1.6 2 0 0 2 2 2 1 Synaptobrevin Longin PF13774.6 ELR21002.1 - 3.1e-07 30.3 0.1 6e-07 29.4 0.1 1.5 1 0 0 1 1 1 1 Regulated-SNARE-like domain UCH PF00443.29 ELR21003.1 - 1.6e-30 106.5 0.0 3.4e-30 105.4 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 ELR21003.1 - 2.7e-11 43.6 0.2 1.5e-10 41.2 0.2 2.2 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase ubiquitin PF00240.23 ELR21003.1 - 2.5e-06 27.1 0.2 0.082 12.7 0.0 3.4 3 0 0 3 3 3 2 Ubiquitin family Ubiquitin_2 PF14560.6 ELR21003.1 - 6e-06 26.6 0.1 0.12 12.9 0.0 2.9 2 0 0 2 2 2 2 Ubiquitin-like domain zf-RanBP PF00641.18 ELR21003.1 - 1.8e-05 23.9 0.5 1.8e-05 23.9 0.5 2.5 2 0 0 2 2 2 1 Zn-finger in Ran binding protein and others Ubiquitin_3 PF14836.6 ELR21003.1 - 0.022 14.7 0.0 0.89 9.6 0.0 2.7 2 0 0 2 2 2 0 Ubiquitin-like domain UN_NPL4 PF11543.8 ELR21003.1 - 0.041 14.4 0.0 10 6.7 0.0 2.8 2 0 0 2 2 2 0 Nuclear pore localisation protein NPL4 USP7_C2 PF14533.6 ELR21003.1 - 0.077 12.7 0.1 0.41 10.3 0.0 2.2 2 1 0 2 2 2 0 Ubiquitin-specific protease C-terminal UBX PF00789.20 ELR21003.1 - 0.16 12.2 0.2 17 5.7 0.0 2.8 2 0 0 2 2 2 0 UBX domain BDV_P10 PF06515.11 ELR21003.1 - 0.33 11.0 2.1 0.54 10.3 0.0 2.3 2 0 0 2 2 2 0 Borna disease virus P10 protein PHD_2 PF13831.6 ELR21003.1 - 1 9.0 3.3 3.4 7.3 0.4 2.7 2 0 0 2 2 2 0 PHD-finger DUF5522 PF17653.1 ELR21004.1 - 9.6e-22 76.7 7.5 9.6e-22 76.7 7.5 1.4 2 0 0 2 2 2 1 Family of unknown function (DUF5522) zf-PARP PF00645.18 ELR21005.1 - 5e-22 78.6 1.0 5e-22 78.6 1.0 2.1 2 1 0 2 2 2 1 Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region AF-4 PF05110.13 ELR21005.1 - 4.1 5.4 43.2 4.4 5.3 43.2 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein Pribosyl_synth PF14572.6 ELR21006.1 - 1.1e-31 110.3 0.7 4e-31 108.5 0.4 1.9 1 1 1 2 2 2 1 Phosphoribosyl synthetase-associated domain Pribosyltran_N PF13793.6 ELR21006.1 - 3.2e-30 104.5 1.2 4.5e-15 55.6 0.2 3.4 2 1 1 3 3 3 2 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyltran PF00156.27 ELR21006.1 - 3e-18 65.8 0.5 5.9e-18 64.9 0.5 1.4 1 0 0 1 1 1 1 Phosphoribosyl transferase domain UPRTase PF14681.6 ELR21006.1 - 0.018 14.5 0.0 0.028 13.9 0.0 1.4 1 0 0 1 1 1 0 Uracil phosphoribosyltransferase Lactamase_B_2 PF12706.7 ELR21007.1 - 3.1e-21 75.8 0.2 1.3e-09 37.9 0.1 3.4 3 0 0 3 3 3 3 Beta-lactamase superfamily domain Lactamase_B_4 PF13691.6 ELR21007.1 - 2.5e-09 36.7 0.0 1e-08 34.7 0.0 2.0 2 0 0 2 2 2 1 tRNase Z endonuclease Lactamase_B PF00753.27 ELR21007.1 - 6.8e-05 23.0 0.2 0.0018 18.3 0.0 2.7 2 0 0 2 2 2 1 Metallo-beta-lactamase superfamily zf-C2H2_6 PF13912.6 ELR21007.1 - 0.032 14.2 0.1 0.057 13.4 0.1 1.4 1 0 0 1 1 1 0 C2H2-type zinc finger Lactamase_B_6 PF16661.5 ELR21007.1 - 0.093 12.1 0.0 0.21 11.0 0.0 1.5 2 0 0 2 2 2 0 Metallo-beta-lactamase superfamily domain Ank_4 PF13637.6 ELR21009.1 - 2.2e-37 126.9 4.1 2e-15 57.0 0.0 6.2 4 2 3 7 7 7 5 Ankyrin repeats (many copies) Ank_2 PF12796.7 ELR21009.1 - 5.3e-35 119.9 0.3 2.9e-12 47.0 0.1 4.0 1 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_5 PF13857.6 ELR21009.1 - 2e-34 117.2 0.8 1.5e-12 47.5 0.0 5.5 1 1 5 6 6 6 5 Ankyrin repeats (many copies) Ank PF00023.30 ELR21009.1 - 3e-33 112.8 0.6 3.1e-06 27.4 0.0 7.2 7 0 0 7 7 7 5 Ankyrin repeat DHHC PF01529.20 ELR21009.1 - 1.6e-31 109.2 12.0 1.6e-31 109.2 12.0 2.5 2 1 0 2 2 2 1 DHHC palmitoyltransferase Ank_3 PF13606.6 ELR21009.1 - 3.1e-30 100.8 1.0 1.8e-05 24.7 0.0 7.5 7 0 0 7 7 7 5 Ankyrin repeat IGFBP PF00219.18 ELR21009.1 - 1.1 10.0 6.1 1.9 9.2 6.1 1.3 1 0 0 1 1 1 0 Insulin-like growth factor binding protein PH PF00169.29 ELR21010.1 - 3.8e-42 143.0 5.4 2e-19 70.0 0.3 3.8 4 0 0 4 4 3 3 PH domain RhoGEF PF00621.20 ELR21010.1 - 1e-30 107.3 0.5 3.5e-30 105.6 0.2 2.1 2 0 0 2 2 2 1 RhoGEF domain PH_11 PF15413.6 ELR21010.1 - 2.1e-10 41.0 7.6 0.0021 18.5 3.4 4.7 3 1 0 3 3 3 3 Pleckstrin homology domain PH_16 PF17838.1 ELR21010.1 - 5e-09 36.1 0.4 3.6e-06 26.8 0.0 3.1 3 0 0 3 3 3 2 PH domain PH_13 PF16652.5 ELR21010.1 - 4.1e-07 29.9 14.8 0.03 14.1 0.4 4.5 3 1 0 3 3 3 2 Pleckstrin homology domain IQ_SEC7_PH PF16453.5 ELR21010.1 - 1.1e-06 28.7 0.3 0.00056 19.9 0.0 2.6 2 0 0 2 2 2 2 PH domain PH_3 PF14593.6 ELR21010.1 - 1.4e-06 28.3 3.2 2.2e-06 27.7 0.2 2.6 3 0 0 3 3 3 1 PH domain PH_8 PF15409.6 ELR21010.1 - 1.8e-05 24.9 1.3 0.00053 20.2 0.1 2.9 2 0 0 2 2 2 1 Pleckstrin homology domain PH_9 PF15410.6 ELR21010.1 - 7.6e-05 23.1 3.3 0.59 10.5 0.0 4.2 3 1 0 3 3 3 1 Pleckstrin homology domain PH_2 PF08458.10 ELR21010.1 - 0.0003 21.1 0.6 2.2 8.7 0.1 3.9 3 0 0 3 3 3 1 Plant pleckstrin homology-like region PH_6 PF15406.6 ELR21010.1 - 0.00043 20.5 4.1 0.33 11.2 0.1 4.9 4 1 1 5 5 5 1 Pleckstrin homology domain PH_5 PF15405.6 ELR21010.1 - 0.023 14.8 1.9 17 5.5 0.0 4.1 4 0 0 4 4 4 0 Pleckstrin homology domain DUF1036 PF06282.11 ELR21010.1 - 0.068 13.7 2.4 0.63 10.6 0.4 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1036) PH_10 PF15411.6 ELR21010.1 - 0.07 13.4 5.1 0.49 10.7 0.0 3.3 2 1 1 3 3 3 0 Pleckstrin homology domain Aldedh PF00171.22 ELR21011.1 - 4.5e-170 566.1 0.7 1.1e-163 545.0 0.1 2.7 2 1 0 2 2 2 2 Aldehyde dehydrogenase family adh_short_C2 PF13561.6 ELR21012.1 - 9.5e-66 221.7 0.3 1.2e-65 221.4 0.3 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 ELR21012.1 - 8.8e-51 172.1 1.2 1.1e-50 171.9 1.2 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 ELR21012.1 - 3e-09 37.0 0.6 4.1e-09 36.6 0.6 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 ELR21012.1 - 6.5e-06 25.8 0.6 7.9e-05 22.2 0.6 2.5 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3HCDH_N PF02737.18 ELR21012.1 - 0.00069 19.5 0.4 0.0011 18.9 0.4 1.3 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain ADH_zinc_N PF00107.26 ELR21012.1 - 0.0057 16.6 0.5 0.029 14.4 0.2 2.0 2 0 0 2 2 2 1 Zinc-binding dehydrogenase 2-Hacid_dh_C PF02826.19 ELR21012.1 - 0.041 13.3 0.3 0.12 11.7 0.1 1.9 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain RmlD_sub_bind PF04321.17 ELR21012.1 - 0.044 12.9 0.1 0.076 12.1 0.0 1.4 1 1 0 1 1 1 0 RmlD substrate binding domain PALP PF00291.25 ELR21012.1 - 0.066 12.6 0.2 0.099 12.0 0.2 1.2 1 0 0 1 1 1 0 Pyridoxal-phosphate dependent enzyme DFP PF04127.15 ELR21012.1 - 0.07 13.0 0.1 0.16 11.8 0.1 1.6 1 0 0 1 1 1 0 DNA / pantothenate metabolism flavoprotein CbiA PF01656.23 ELR21012.1 - 0.077 13.1 0.1 0.29 11.2 0.1 1.9 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain HMG_box PF00505.19 ELR21013.1 - 5.1e-23 81.3 0.3 5.1e-23 81.3 0.3 2.6 2 1 0 2 2 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 ELR21013.1 - 1e-11 45.2 0.3 1e-11 45.2 0.3 2.7 2 1 1 3 3 2 1 HMG-box domain HMG_box_5 PF14887.6 ELR21013.1 - 0.0019 18.1 0.2 0.0019 18.1 0.2 2.8 2 1 1 3 3 2 1 HMG (high mobility group) box 5 RPN2_C PF18004.1 ELR21013.1 - 0.11 12.4 19.5 0.2 11.5 19.5 1.4 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain SRP-alpha_N PF04086.13 ELR21013.1 - 0.15 11.9 19.8 0.19 11.6 19.8 1.1 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal Peptidase_M61 PF05299.12 ELR21013.1 - 0.2 12.0 0.8 0.84 10.0 0.0 2.1 2 0 0 2 2 2 0 M61 glycyl aminopeptidase DUF4666 PF15697.5 ELR21013.1 - 0.63 10.7 6.3 1.4 9.7 5.9 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4666) Ureide_permease PF07168.11 ELR21013.1 - 0.72 8.5 2.6 0.87 8.3 2.6 1.1 1 0 0 1 1 1 0 Ureide permease NPR3 PF03666.13 ELR21013.1 - 0.95 8.2 9.6 0.94 8.2 9.6 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Dicty_REP PF05086.12 ELR21013.1 - 1.4 6.8 8.9 1.5 6.7 8.9 1.0 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein DUF3807 PF12720.7 ELR21013.1 - 1.5 9.1 14.2 2.3 8.5 14.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) Presenilin PF01080.17 ELR21013.1 - 1.6 7.4 7.2 1.5 7.5 7.2 1.1 1 0 0 1 1 1 0 Presenilin Connexin PF00029.19 ELR21013.1 - 5.4 6.7 7.9 7.2 6.3 7.9 1.2 1 0 0 1 1 1 0 Connexin Zip PF02535.22 ELR21013.1 - 5.4 6.1 4.7 5.2 6.2 4.7 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter DUF5427 PF10310.9 ELR21013.1 - 6.6 5.6 16.3 7.2 5.5 16.3 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5427) ABM PF03992.16 ELR21014.1 - 5.8e-17 61.6 0.1 9e-17 61.0 0.1 1.3 1 0 0 1 1 1 1 Antibiotic biosynthesis monooxygenase AP_endonuc_2 PF01261.24 ELR21015.1 - 1.1e-11 44.7 0.0 4.1e-11 42.7 0.0 1.9 1 1 0 1 1 1 1 Xylose isomerase-like TIM barrel AAR2 PF05282.11 ELR21015.1 - 0.061 12.7 1.0 0.06 12.7 1.0 1.1 1 0 0 1 1 1 0 AAR2 protein XRCC4 PF06632.12 ELR21015.1 - 7 5.4 12.5 9.5 5.0 12.5 1.2 1 0 0 1 1 1 0 DNA double-strand break repair and V(D)J recombination protein XRCC4 DTHCT PF08070.11 ELR21015.1 - 9.2 7.1 30.7 25 5.7 29.6 1.9 1 1 0 1 1 1 0 DTHCT (NUC029) region EF-hand_1 PF00036.32 ELR21018.1 - 2.1e-18 64.4 2.0 3.6e-10 38.7 0.1 2.1 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 ELR21018.1 - 7.1e-15 53.6 0.8 5.8e-10 38.3 0.2 2.2 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.6 ELR21018.1 - 9.7e-14 51.6 0.0 1.1e-13 51.4 0.0 1.1 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.6 ELR21018.1 - 3.8e-13 49.1 2.8 2.5e-09 36.9 0.1 2.2 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 ELR21018.1 - 4.6e-12 44.9 1.4 1.9e-07 30.2 0.2 2.3 2 0 0 2 2 2 2 EF hand EF-hand_9 PF14658.6 ELR21018.1 - 2.4e-06 27.8 0.0 2.7e-06 27.6 0.0 1.1 1 0 0 1 1 1 1 EF-hand domain UPF0154 PF03672.13 ELR21018.1 - 0.012 15.6 0.0 0.035 14.1 0.0 1.6 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0154) Caleosin PF05042.13 ELR21018.1 - 0.044 13.7 0.0 0.053 13.4 0.0 1.3 1 1 0 1 1 1 0 Caleosin related protein SPARC_Ca_bdg PF10591.9 ELR21018.1 - 0.071 13.4 0.0 0.077 13.3 0.0 1.1 1 0 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 ELR21018.1 - 0.075 13.0 0.0 0.097 12.6 0.0 1.2 1 0 0 1 1 1 0 Cytoskeletal-regulatory complex EF hand Dockerin_1 PF00404.18 ELR21018.1 - 0.11 12.8 0.3 0.39 11.0 0.4 1.7 1 1 1 2 2 2 0 Dockerin type I domain Gpi16 PF04113.14 ELR21019.1 - 5.7e-98 328.8 0.0 1.7e-95 320.6 0.0 2.9 1 1 0 1 1 1 1 Gpi16 subunit, GPI transamidase component LRR_8 PF13855.6 ELR21020.1 - 4e-14 52.1 1.9 3e-09 36.5 1.9 3.4 3 0 0 3 3 3 2 Leucine rich repeat LRR_4 PF12799.7 ELR21020.1 - 1.4e-11 44.5 5.5 1.1e-07 32.0 0.9 3.7 3 0 0 3 3 3 2 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 ELR21020.1 - 3.9e-08 32.7 9.0 0.0085 16.1 0.1 4.8 5 0 0 5 5 5 2 Leucine Rich repeat Roc PF08477.13 ELR21020.1 - 1.7e-07 31.5 0.0 3.4e-07 30.5 0.0 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase LRR_1 PF00560.33 ELR21020.1 - 0.0021 18.3 2.1 25 5.9 0.1 4.8 4 0 0 4 4 4 0 Leucine Rich Repeat AAA PF00004.29 ELR21020.1 - 0.012 16.1 0.0 0.055 13.9 0.0 2.2 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Ras PF00071.22 ELR21020.1 - 0.012 15.3 0.0 0.048 13.3 0.0 1.9 1 1 0 1 1 1 0 Ras family AAA_33 PF13671.6 ELR21020.1 - 0.019 15.2 0.1 0.068 13.3 0.1 2.1 1 1 0 1 1 1 0 AAA domain Septin PF00735.18 ELR21020.1 - 0.026 13.8 0.0 0.042 13.1 0.0 1.3 1 0 0 1 1 1 0 Septin AAA_22 PF13401.6 ELR21020.1 - 0.031 14.5 0.1 0.2 11.9 0.0 2.4 3 0 0 3 3 3 0 AAA domain NB-ARC PF00931.22 ELR21020.1 - 0.044 13.0 0.0 0.1 11.8 0.0 1.5 1 0 0 1 1 1 0 NB-ARC domain Sigma54_activat PF00158.26 ELR21020.1 - 0.06 13.0 0.0 0.14 11.8 0.0 1.6 1 0 0 1 1 1 0 Sigma-54 interaction domain FumaraseC_C PF10415.9 ELR21020.1 - 0.068 13.6 0.2 0.32 11.4 0.0 2.3 1 1 1 2 2 2 0 Fumarase C C-terminus AAA_7 PF12775.7 ELR21020.1 - 0.089 12.3 0.0 0.18 11.3 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region DUF3854 PF12965.7 ELR21020.1 - 0.1 12.6 0.1 1.8 8.5 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF3854) MMR_HSR1 PF01926.23 ELR21020.1 - 0.14 12.3 0.0 0.35 11.0 0.0 1.8 1 0 0 1 1 1 0 50S ribosome-binding GTPase LRR_9 PF14580.6 ELR21020.1 - 0.16 11.5 2.2 0.56 9.7 0.9 2.1 1 1 1 2 2 2 0 Leucine-rich repeat FliN_N PF16973.5 ELR21021.1 - 0.01 15.7 0.5 0.029 14.2 0.5 1.7 1 0 0 1 1 1 0 Flagellar motor switch protein FliN N-terminal DUF4710 PF15828.5 ELR21021.1 - 0.099 12.8 0.2 0.3 11.2 0.2 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF4710) DOG1 PF14144.6 ELR21021.1 - 0.12 12.6 0.1 5.9 7.2 0.0 2.8 1 1 1 2 2 2 0 Seed dormancy control Gpi16 PF04113.14 ELR21022.1 - 4.3e-20 71.7 0.0 3.7e-19 68.6 0.0 1.9 1 1 0 1 1 1 1 Gpi16 subunit, GPI transamidase component MMM1 PF10296.9 ELR21023.1 - 5.8e-12 45.3 0.0 5.5e-10 38.8 0.0 4.7 2 2 2 4 4 4 2 Maintenance of mitochondrial morphology protein 1 LRR_8 PF13855.6 ELR21023.1 - 7.3e-06 25.7 0.1 1.7e-05 24.5 0.1 1.6 1 0 0 1 1 1 1 Leucine rich repeat LRR_4 PF12799.7 ELR21023.1 - 4.3e-05 23.8 0.1 0.0062 16.9 0.0 2.6 1 1 1 2 2 2 2 Leucine Rich repeats (2 copies) AAA PF00004.29 ELR21023.1 - 0.03 14.7 0.0 0.097 13.1 0.0 1.9 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Roc PF08477.13 ELR21023.1 - 0.049 13.9 0.0 0.1 12.8 0.0 1.5 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase AAA_7 PF12775.7 ELR21023.1 - 0.17 11.4 0.0 0.34 10.4 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region COQ9 PF08511.11 ELR21024.1 - 7.9e-30 102.5 1.1 1.2e-29 101.8 1.1 1.3 1 0 0 1 1 1 1 COQ9 DUF3318 PF11780.8 ELR21025.1 - 0.088 12.7 0.0 0.15 12.0 0.0 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3318) MOR2-PAG1_mid PF14228.6 ELR21026.1 - 1.2e-10 39.8 0.5 2.6e-10 38.7 0.5 1.5 1 0 0 1 1 1 1 Cell morphogenesis central region Chromo PF00385.24 ELR21027.1 - 2.7e-18 65.6 5.1 5.7e-12 45.4 1.8 2.5 2 0 0 2 2 2 2 Chromo (CHRromatin Organisation MOdifier) domain zf-4CXXC_R1 PF10497.9 ELR21027.1 - 1.1e-08 35.1 18.4 1.1e-08 35.1 18.4 2.2 2 1 0 2 2 2 1 Zinc-finger domain of monoamine-oxidase A repressor R1 PEHE PF15275.6 ELR21027.1 - 8.6e-06 26.4 2.7 8.6e-06 26.4 2.7 3.5 3 1 0 3 3 3 1 PEHE domain Tudor-knot PF11717.8 ELR21027.1 - 3.3e-05 23.7 0.4 0.086 12.7 0.0 2.7 2 0 0 2 2 2 2 RNA binding activity-knot of a chromodomain Mtf2_C PF14061.6 ELR21027.1 - 0.12 12.5 0.5 0.43 10.8 0.1 2.1 2 0 0 2 2 2 0 Polycomb-like MTF2 factor 2 DUF3763 PF12592.8 ELR21027.1 - 0.3 11.2 1.3 25 5.0 0.0 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3763) GRP PF07172.11 ELR21029.1 - 5.4e-06 27.0 33.5 5.4e-06 27.0 33.5 2.8 4 0 0 4 4 4 1 Glycine rich protein family DUF2976 PF11190.8 ELR21029.1 - 0.1 12.4 3.5 0.35 10.7 3.5 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF2976) Amastin PF07344.11 ELR21029.1 - 0.15 11.9 7.9 0.34 10.7 7.6 1.9 1 1 0 1 1 1 0 Amastin surface glycoprotein Pkinase_Tyr PF07714.17 ELR21030.1 - 6.8e-61 205.8 0.0 9e-61 205.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ELR21030.1 - 3.9e-51 174.0 0.0 5.4e-51 173.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain SH2 PF00017.24 ELR21030.1 - 1e-15 57.6 0.0 2e-15 56.7 0.0 1.5 1 0 0 1 1 1 1 SH2 domain Haspin_kinase PF12330.8 ELR21030.1 - 0.0025 16.8 0.0 0.011 14.8 0.0 1.8 2 0 0 2 2 2 1 Haspin like kinase domain APH PF01636.23 ELR21030.1 - 0.0029 17.6 0.1 0.0081 16.1 0.1 1.7 2 0 0 2 2 2 1 Phosphotransferase enzyme family EF-hand_12 PF17901.1 ELR21030.1 - 0.011 16.2 0.0 0.031 14.7 0.0 1.8 1 0 0 1 1 1 0 EF-hand fold domain SH2_2 PF14633.6 ELR21030.1 - 0.098 12.0 0.0 0.2 11.0 0.0 1.4 1 0 0 1 1 1 0 SH2 domain F-box-like PF12937.7 ELR21031.1 - 3.3e-10 39.7 0.1 8e-10 38.5 0.1 1.7 1 0 0 1 1 1 1 F-box-like ZZ PF00569.17 ELR21031.1 - 3.9e-10 39.4 9.7 7.1e-10 38.5 9.7 1.4 1 0 0 1 1 1 1 Zinc finger, ZZ type F-box PF00646.33 ELR21031.1 - 5.8e-07 29.2 0.0 0.00013 21.8 0.0 2.5 2 0 0 2 2 2 2 F-box domain Ras PF00071.22 ELR21031.1 - 4.7e-05 23.0 0.0 0.0001 21.9 0.0 1.5 1 0 0 1 1 1 1 Ras family zf-UBR PF02207.20 ELR21031.1 - 0.13 12.5 6.1 0.28 11.4 6.1 1.5 1 0 0 1 1 1 0 Putative zinc finger in N-recognin (UBR box) RasGEF PF00617.19 ELR21032.1 - 2.8e-35 122.1 0.3 2.1e-33 116.0 0.3 2.4 1 1 0 1 1 1 1 RasGEF domain RhoGAP PF00620.27 ELR21032.1 - 2e-34 118.6 0.0 3.7e-34 117.8 0.0 1.4 1 0 0 1 1 1 1 RhoGAP domain RasGEF_N PF00618.20 ELR21032.1 - 1.9e-17 63.4 0.0 8e-17 61.4 0.0 2.2 2 0 0 2 2 2 1 RasGEF N-terminal motif SnAC PF14619.6 ELR21033.1 - 0.27 11.9 2.6 1.6 9.4 0.2 2.8 2 0 0 2 2 2 0 Snf2-ATP coupling, chromatin remodelling complex Methyltransf_16 PF10294.9 ELR21034.1 - 8.8e-32 110.2 0.0 9.8e-19 67.7 0.0 2.3 2 0 0 2 2 2 2 Lysine methyltransferase Methyltransf_23 PF13489.6 ELR21034.1 - 0.087 12.7 0.0 0.13 12.1 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain MTS PF05175.14 ELR21034.1 - 0.16 11.5 0.0 0.3 10.6 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase small domain Kelch_4 PF13418.6 ELR21035.1 - 2.9e-27 94.4 4.3 1.6e-05 24.8 0.0 5.3 5 0 0 5 5 5 5 Galactose oxidase, central domain Kelch_3 PF13415.6 ELR21035.1 - 4.3e-25 87.4 14.6 3.6e-06 27.1 0.3 6.4 6 1 0 6 6 6 6 Galactose oxidase, central domain Kelch_6 PF13964.6 ELR21035.1 - 2.3e-21 75.3 0.1 0.00026 21.2 0.0 5.4 5 0 0 5 5 5 4 Kelch motif Kelch_5 PF13854.6 ELR21035.1 - 8.2e-19 67.2 8.4 3.9e-05 23.5 0.0 5.3 5 0 0 5 5 5 5 Kelch motif Kelch_1 PF01344.25 ELR21035.1 - 5.1e-14 51.6 9.0 0.0028 17.2 0.1 6.4 6 0 0 6 6 6 4 Kelch motif Kelch_2 PF07646.15 ELR21035.1 - 2.6e-12 46.2 8.2 0.06 13.4 0.0 5.2 5 0 0 5 5 5 4 Kelch motif SMC_N PF02463.19 ELR21035.1 - 0.07 12.5 0.0 0.1 12.1 0.0 1.1 1 0 0 1 1 1 0 RecF/RecN/SMC N terminal domain Ras PF00071.22 ELR21036.1 - 3.4e-39 134.0 0.0 6.3e-39 133.2 0.0 1.3 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR21036.1 - 1.2e-11 44.8 0.1 2.3e-11 43.9 0.1 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase F-box-like PF12937.7 ELR21036.1 - 6.1e-09 35.6 0.1 1.2e-08 34.7 0.1 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ELR21036.1 - 0.00087 19.1 0.1 0.0024 17.7 0.1 1.8 1 1 0 1 1 1 1 F-box domain CYTH PF01928.21 ELR21037.1 - 0.0011 18.9 0.0 0.0015 18.5 0.0 1.2 1 0 0 1 1 1 1 CYTH domain Sel1 PF08238.12 ELR21038.1 - 5.6e-95 309.6 60.5 5.6e-10 39.6 0.5 14.5 15 0 0 15 15 15 12 Sel1 repeat zf-C3HC4_3 PF13920.6 ELR21038.1 - 0.022 14.6 2.6 0.048 13.5 2.6 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 ELR21038.1 - 0.038 13.9 3.8 0.072 13.0 3.8 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 ELR21038.1 - 0.11 12.5 1.8 0.23 11.5 1.8 1.5 1 0 0 1 1 1 0 RING-type zinc-finger zf-RING_5 PF14634.6 ELR21038.1 - 0.13 12.2 4.4 0.3 11.1 4.4 1.6 1 0 0 1 1 1 0 zinc-RING finger domain zf-RING_2 PF13639.6 ELR21038.1 - 0.14 12.5 1.9 0.3 11.4 1.9 1.5 1 0 0 1 1 1 0 Ring finger domain Prok-RING_4 PF14447.6 ELR21038.1 - 0.6 10.0 3.2 1.2 9.0 3.2 1.5 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 MIT PF04212.18 ELR21038.1 - 0.66 10.1 10.6 34 4.6 0.1 6.0 7 0 0 7 7 7 0 MIT (microtubule interacting and transport) domain zf-C3HC4_4 PF15227.6 ELR21038.1 - 0.95 9.7 3.9 2.4 8.4 3.9 1.8 1 1 0 1 1 1 0 zinc finger of C3HC4-type, RING TPR_6 PF13174.6 ELR21038.1 - 2.7 8.8 25.5 0.52 11.1 0.2 8.7 10 1 0 10 10 10 0 Tetratricopeptide repeat Pkinase_Tyr PF07714.17 ELR21039.1 - 1.7e-64 217.6 0.0 2.2e-64 217.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ELR21039.1 - 1.3e-50 172.2 0.0 1.9e-50 171.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain SH2 PF00017.24 ELR21039.1 - 3.3e-13 49.6 0.0 1e-12 48.0 0.0 1.8 2 0 0 2 2 2 1 SH2 domain APH PF01636.23 ELR21039.1 - 0.00044 20.3 0.0 0.0013 18.8 0.0 1.7 1 1 0 1 1 1 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 ELR21039.1 - 0.00056 19.0 0.6 0.00091 18.3 0.6 1.3 1 1 0 1 1 1 1 Haspin like kinase domain Choline_kinase PF01633.20 ELR21039.1 - 0.11 12.0 0.5 0.22 11.1 0.5 1.5 1 1 0 1 1 1 0 Choline/ethanolamine kinase Ydr279_N PF17745.1 ELR21040.1 - 3.4e-16 59.2 0.0 6.8e-16 58.3 0.0 1.5 1 0 0 1 1 1 1 Ydr279p protein triple barrel domain HAD_2 PF13419.6 ELR21042.1 - 1.2e-10 41.7 0.0 1.5e-10 41.5 0.0 1.1 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 ELR21042.1 - 2.6e-06 27.9 0.0 3.2e-06 27.6 0.0 1.1 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 ELR21042.1 - 1.6e-05 24.8 0.0 2.5e-05 24.3 0.0 1.2 1 0 0 1 1 1 1 HAD-hyrolase-like HAD PF12710.7 ELR21042.1 - 0.0085 16.5 0.0 0.011 16.1 0.0 1.3 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase DUF962 PF06127.11 ELR21043.1 - 2.3e-35 120.5 2.0 2.6e-35 120.4 2.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF962) HAD_2 PF13419.6 ELR21044.1 - 6.7e-11 42.6 0.0 7.6e-11 42.4 0.0 1.2 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 ELR21044.1 - 2.4e-07 31.3 0.0 1.1e-06 29.1 0.0 1.8 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 ELR21044.1 - 2.1e-05 24.5 0.0 3.4e-05 23.8 0.0 1.3 1 0 0 1 1 1 1 HAD-hyrolase-like HAD PF12710.7 ELR21044.1 - 0.00038 20.9 0.0 0.00044 20.7 0.0 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_6 PF13344.6 ELR21044.1 - 0.088 12.9 0.0 0.56 10.4 0.0 2.1 2 1 0 2 2 2 0 Haloacid dehalogenase-like hydrolase F-box-like PF12937.7 ELR21045.1 - 1.6e-05 24.7 0.1 3.2e-05 23.7 0.1 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ELR21045.1 - 0.014 15.2 1.3 0.042 13.7 1.3 1.8 1 1 0 1 1 1 0 F-box domain PH PF00169.29 ELR21046.1 - 1.3e-16 61.0 1.5 2e-16 60.4 1.5 1.3 1 0 0 1 1 1 1 PH domain PH_3 PF14593.6 ELR21046.1 - 3.9e-07 30.1 0.1 7.4e-07 29.2 0.1 1.5 1 0 0 1 1 1 1 PH domain PH_11 PF15413.6 ELR21046.1 - 9.4e-06 26.0 2.3 9.3e-05 22.8 2.3 2.1 1 1 0 1 1 1 1 Pleckstrin homology domain PH_2 PF08458.10 ELR21046.1 - 0.00055 20.2 0.2 0.001 19.4 0.2 1.4 1 0 0 1 1 1 1 Plant pleckstrin homology-like region PH_8 PF15409.6 ELR21046.1 - 0.0027 18.0 0.6 0.005 17.1 0.6 1.5 1 1 0 1 1 1 1 Pleckstrin homology domain Mcp5_PH PF12814.7 ELR21046.1 - 0.074 13.2 0.4 0.15 12.2 0.2 1.6 1 1 0 1 1 1 0 Meiotic cell cortex C-terminal pleckstrin homology LBP_BPI_CETP_C PF02886.17 ELR21048.1 - 1.1e-12 48.0 0.0 1.5e-12 47.5 0.0 1.2 1 0 0 1 1 1 1 LBP / BPI / CETP family, C-terminal domain DUF1640 PF07798.11 ELR21049.1 - 0.99 9.4 14.3 2.7 8.0 14.3 1.6 1 1 1 2 2 2 0 Protein of unknown function (DUF1640) DUF2508 PF10704.9 ELR21049.1 - 4.5 7.5 13.0 0.28 11.4 5.6 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF2508) DUF1998 PF09369.10 ELR21050.1 - 6e-05 23.7 1.9 9.2e-05 23.1 1.9 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1998) UNC-93 PF05978.16 ELR21051.1 - 2.2e-15 56.7 9.1 9.7e-15 54.6 9.1 1.9 1 1 0 1 1 1 1 Ion channel regulatory protein UNC-93 Helicase_C PF00271.31 ELR21051.1 - 3e-10 40.4 0.0 5.8e-10 39.5 0.0 1.4 1 0 0 1 1 1 1 Helicase conserved C-terminal domain MFS_1 PF07690.16 ELR21051.1 - 0.099 11.5 17.7 0.13 11.1 16.5 1.8 2 1 1 3 3 3 0 Major Facilitator Superfamily BRCT_2 PF16589.5 ELR21052.1 - 5.7e-05 23.4 0.0 0.00021 21.6 0.0 1.7 1 1 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain BRCT PF00533.26 ELR21052.1 - 0.002 18.5 0.0 0.0049 17.2 0.0 1.5 1 1 1 2 2 2 1 BRCA1 C Terminus (BRCT) domain LIG3_BRCT PF16759.5 ELR21052.1 - 0.01 16.1 0.0 0.016 15.5 0.0 1.3 1 0 0 1 1 1 0 DNA ligase 3 BRCT domain DEAD PF00270.29 ELR21053.1 - 2.1e-11 43.9 0.0 3.3e-11 43.3 0.0 1.2 1 0 0 1 1 1 1 DEAD/DEAH box helicase UQ_con PF00179.26 ELR21054.1 - 3.1e-17 62.5 0.1 7.5e-17 61.3 0.1 1.6 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme zf-B_box PF00643.24 ELR21054.1 - 3e-07 30.5 1.8 3e-07 30.5 1.8 3.3 3 1 0 3 3 3 1 B-box zinc finger UEV PF05743.13 ELR21054.1 - 0.00022 21.1 0.1 0.00043 20.1 0.1 1.4 1 0 0 1 1 1 1 UEV domain zf-C3HC4_3 PF13920.6 ELR21054.1 - 0.0012 18.6 2.1 0.0012 18.6 2.1 2.3 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) TarH PF02203.15 ELR21054.1 - 0.093 12.7 3.6 0.26 11.2 3.6 1.7 1 0 0 1 1 1 0 Tar ligand binding domain homologue zf-RING_14 PF17978.1 ELR21054.1 - 0.099 13.1 2.2 0.48 10.9 0.3 2.4 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain UFC1 PF08694.11 ELR21054.1 - 0.14 11.8 1.3 0.49 10.0 0.0 2.4 3 0 0 3 3 3 0 Ubiquitin-fold modifier-conjugating enzyme 1 Rx_N PF18052.1 ELR21054.1 - 0.21 11.9 4.6 1.2 9.4 4.3 2.4 2 0 0 2 2 2 0 Rx N-terminal domain SOAR PF16533.5 ELR21054.1 - 0.3 11.1 17.0 0.067 13.2 7.8 3.2 2 1 1 3 3 3 0 STIM1 Orai1-activating region zf-UBP PF02148.19 ELR21054.1 - 2.6 8.5 5.1 11 6.4 0.1 2.8 2 1 0 2 2 2 0 Zn-finger in ubiquitin-hydrolases and other protein Apt1 PF10351.9 ELR21054.1 - 9.8 4.9 11.8 1.7 7.4 2.9 2.4 2 0 0 2 2 2 0 Golgi-body localisation protein domain Synapsin_C PF02750.14 ELR21055.1 - 1.2e-56 191.4 0.0 1.6e-56 191.1 0.0 1.1 1 0 0 1 1 1 1 Synapsin, ATP binding domain Synapsin PF02078.16 ELR21055.1 - 5.3e-19 68.4 0.0 1.3e-18 67.1 0.0 1.7 2 0 0 2 2 2 1 Synapsin, N-terminal domain RNA_pol_Rpc4 PF05132.14 ELR21055.1 - 0.062 13.7 2.0 0.085 13.3 2.0 1.3 1 0 0 1 1 1 0 RNA polymerase III RPC4 Epimerase PF01370.21 ELR21056.1 - 2.6e-18 66.4 0.0 3.6e-18 65.9 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 ELR21056.1 - 3.1e-12 46.2 0.0 4.9e-12 45.6 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein GDP_Man_Dehyd PF16363.5 ELR21056.1 - 6.5e-11 42.2 0.0 9.5e-11 41.7 0.0 1.2 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase NAD_binding_4 PF07993.12 ELR21056.1 - 2.2e-10 40.2 0.0 2.5e-07 30.1 0.0 2.1 1 1 1 2 2 2 2 Male sterility protein RmlD_sub_bind PF04321.17 ELR21056.1 - 3.5e-09 36.2 0.0 6.6e-09 35.3 0.0 1.4 1 1 0 1 1 1 1 RmlD substrate binding domain 3Beta_HSD PF01073.19 ELR21056.1 - 1.2e-08 34.4 0.0 1.5e-08 34.0 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.6 ELR21056.1 - 8.1e-07 29.1 0.0 1.3e-06 28.5 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding Sacchrp_dh_NADP PF03435.18 ELR21056.1 - 0.011 16.0 0.0 0.018 15.3 0.0 1.4 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain DapB_N PF01113.20 ELR21056.1 - 0.062 13.4 0.0 0.15 12.2 0.0 1.6 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus RPE65 PF03055.15 ELR21057.1 - 1.5e-111 373.8 0.0 1.9e-111 373.5 0.0 1.0 1 0 0 1 1 1 1 Retinal pigment epithelial membrane protein PQQ PF01011.21 ELR21057.1 - 0.11 12.5 0.0 1.7 8.7 0.0 2.6 2 0 0 2 2 2 0 PQQ enzyme repeat RPE65 PF03055.15 ELR21058.1 - 5.1e-108 362.2 0.0 6.5e-108 361.9 0.0 1.0 1 0 0 1 1 1 1 Retinal pigment epithelial membrane protein LIM PF00412.22 ELR21059.1 - 1.4e-16 60.5 19.2 1.8e-09 37.6 6.5 2.6 2 1 0 2 2 2 2 LIM domain zinc_ribbon_4 PF13717.6 ELR21059.1 - 0.18 11.8 0.0 0.18 11.8 0.0 4.8 5 1 0 5 5 5 0 zinc-ribbon domain Plectin PF00681.20 ELR21059.1 - 0.19 11.6 0.0 0.33 10.9 0.0 1.3 1 0 0 1 1 1 0 Plectin repeat DUF2321 PF10083.9 ELR21059.1 - 4 7.0 6.9 4.4 6.9 5.7 1.6 1 1 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2321) zf-SNAP50_C PF12251.8 ELR21059.1 - 5.1 6.7 15.9 0.31 10.7 2.9 2.7 1 1 1 2 2 2 0 snRNA-activating protein of 50kDa MW C terminal DUF1993 PF09351.10 ELR21060.1 - 0.14 12.3 1.8 0.49 10.5 1.8 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF1993) V_ATPase_I PF01496.19 ELR21060.1 - 8 4.2 6.0 13 3.6 6.0 1.4 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family ABM PF03992.16 ELR21061.1 - 3.2e-06 27.2 0.0 4.6e-06 26.7 0.0 1.3 1 0 0 1 1 1 1 Antibiotic biosynthesis monooxygenase DUF4188 PF13826.6 ELR21061.1 - 0.0072 16.7 0.0 0.0092 16.3 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4188) R3H PF01424.22 ELR21062.1 - 1.3e-12 47.5 0.1 2.1e-12 46.8 0.1 1.4 1 0 0 1 1 1 1 R3H domain G-patch PF01585.23 ELR21062.1 - 1.3e-10 41.0 1.9 2.6e-10 40.0 1.9 1.5 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.7 ELR21062.1 - 0.038 14.1 0.7 0.038 14.1 0.7 2.3 2 0 0 2 2 2 0 G-patch domain DHFR_1 PF00186.19 ELR21064.1 - 1.8e-30 105.7 0.0 4.6e-30 104.4 0.0 1.6 1 1 0 1 1 1 1 Dihydrofolate reductase Pkinase PF00069.25 ELR21067.1 - 1.2e-37 129.7 0.1 4.8e-37 127.8 0.0 2.1 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR21067.1 - 1.5e-25 90.0 0.0 7.7e-25 87.6 0.0 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ELR21067.1 - 0.039 13.3 0.1 0.094 12.0 0.0 1.7 2 0 0 2 2 2 0 Kinase-like Amidohydro_3 PF07969.11 ELR21067.1 - 0.081 12.4 0.3 5.1 6.4 0.2 2.1 2 0 0 2 2 2 0 Amidohydrolase family Siah-Interact_N PF09032.11 ELR21067.1 - 2.5 8.4 10.5 4.5 7.7 3.0 2.8 2 0 0 2 2 2 0 Siah interacting protein, N terminal Ras PF00071.22 ELR21068.1 - 1.1e-47 161.7 0.0 1.4e-47 161.3 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR21068.1 - 9.2e-17 61.4 0.0 1.3e-16 60.9 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR21068.1 - 0.00012 21.6 0.0 0.00017 21.1 0.0 1.5 1 1 0 1 1 1 1 ADP-ribosylation factor family RFX_DNA_binding PF02257.15 ELR21069.1 - 1e-13 51.7 0.0 1.8e-13 50.9 0.0 1.4 1 0 0 1 1 1 1 RFX DNA-binding domain Semialdhyde_dhC PF02774.18 ELR21069.1 - 0.17 11.9 0.1 0.33 11.0 0.1 1.4 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, dimerisation domain Helicase_C PF00271.31 ELR21070.1 - 2.9e-18 66.2 0.1 3.7e-15 56.2 0.0 2.7 2 0 0 2 2 2 2 Helicase conserved C-terminal domain DEAD PF00270.29 ELR21070.1 - 9.7e-10 38.5 0.0 2e-09 37.5 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 ELR21070.1 - 8.7e-05 22.6 0.0 0.00025 21.1 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit TFIIE-A_C PF11521.8 ELR21070.1 - 1.4 9.2 7.2 0.24 11.7 0.4 3.1 3 0 0 3 3 3 0 C-terminal general transcription factor TFIIE alpha Tctex-1 PF03645.13 ELR21071.1 - 0.093 13.0 0.0 0.16 12.2 0.0 1.3 1 0 0 1 1 1 0 Tctex-1 family EBP PF05241.12 ELR21072.1 - 5.6e-30 104.1 5.1 7.2e-30 103.8 5.1 1.1 1 0 0 1 1 1 1 Emopamil binding protein Zip PF02535.22 ELR21072.1 - 0.096 11.9 1.5 5.2 6.2 0.1 2.1 2 0 0 2 2 2 0 ZIP Zinc transporter DUF2781 PF10914.8 ELR21072.1 - 0.11 12.9 8.9 0.47 10.9 8.9 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF2781) UNC-93 PF05978.16 ELR21073.1 - 1.6e-14 53.9 11.4 1.6e-14 53.9 11.4 4.0 3 2 0 3 3 3 2 Ion channel regulatory protein UNC-93 MFS_1 PF07690.16 ELR21073.1 - 2.6e-14 52.9 24.4 7.1e-10 38.3 3.6 2.8 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF4834 PF16118.5 ELR21073.1 - 0.12 13.4 4.0 4.1 8.4 0.0 3.2 4 0 0 4 4 4 0 Domain of unknown function (DUF4834) SNF2_N PF00176.23 ELR21074.1 - 4.1e-36 124.4 0.0 2.2e-20 72.7 0.0 2.4 1 1 1 2 2 2 2 SNF2 family N-terminal domain Helicase_C PF00271.31 ELR21074.1 - 1.8e-15 57.2 0.0 5.3e-15 55.7 0.0 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain HDA2-3 PF11496.8 ELR21074.1 - 1.6e-10 40.7 0.0 4.4e-10 39.2 0.0 1.7 1 0 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 ResIII PF04851.15 ELR21074.1 - 5.9e-09 36.2 0.0 1.8e-08 34.6 0.0 1.9 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit zf-RanBP PF00641.18 ELR21074.1 - 3.1e-05 23.2 2.3 6.4e-05 22.2 2.3 1.5 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others DEAD PF00270.29 ELR21074.1 - 3.6e-05 23.6 0.0 7.7e-05 22.5 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase BRCT_2 PF16589.5 ELR21074.1 - 0.0062 16.9 0.0 0.03 14.7 0.0 2.2 1 1 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain BRCT PF00533.26 ELR21074.1 - 0.066 13.6 0.0 0.23 11.9 0.0 2.0 2 0 0 2 2 2 0 BRCA1 C Terminus (BRCT) domain ABC_membrane_2 PF06472.15 ELR21075.1 - 1.9e-85 286.6 4.7 2.4e-85 286.2 4.7 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region 2 ABC_tran PF00005.27 ELR21075.1 - 1.6e-15 57.9 0.0 2.8e-15 57.0 0.0 1.4 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 ELR21075.1 - 0.00011 21.7 0.0 0.21 11.0 0.0 2.2 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 ELR21075.1 - 0.0043 17.6 0.0 0.0081 16.7 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_21 PF13304.6 ELR21075.1 - 0.0071 16.2 0.0 0.012 15.5 0.0 1.3 1 0 0 1 1 1 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 ELR21075.1 - 0.015 15.0 0.0 0.036 13.8 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_16 PF13191.6 ELR21075.1 - 0.018 15.4 0.0 0.31 11.4 0.0 2.5 2 1 0 2 2 2 0 AAA ATPase domain AAA_27 PF13514.6 ELR21075.1 - 0.069 12.7 0.0 0.13 11.8 0.0 1.3 1 0 0 1 1 1 0 AAA domain Flavi_M PF01004.19 ELR21075.1 - 0.11 12.3 0.1 9.9 6.0 0.0 2.5 2 0 0 2 2 2 0 Flavivirus envelope glycoprotein M NACHT PF05729.12 ELR21075.1 - 0.12 12.2 0.0 0.24 11.3 0.0 1.4 1 0 0 1 1 1 0 NACHT domain AAA_24 PF13479.6 ELR21075.1 - 0.22 11.2 0.0 4.2 7.1 0.0 2.2 2 0 0 2 2 2 0 AAA domain LapA_dom PF06305.11 ELR21077.1 - 0.012 15.4 0.9 5.4 6.9 0.0 2.7 3 0 0 3 3 3 0 Lipopolysaccharide assembly protein A domain T2SSM PF04612.12 ELR21077.1 - 0.21 11.7 1.3 0.27 11.3 0.0 1.7 2 0 0 2 2 2 0 Type II secretion system (T2SS), protein M DUF2181 PF10223.9 ELR21078.1 - 6.5e-43 146.9 0.0 4.3e-27 95.1 0.0 2.0 1 1 1 2 2 2 2 Uncharacterized conserved protein (DUF2181) NapE PF06796.11 ELR21078.1 - 0.058 12.9 0.1 0.093 12.3 0.1 1.3 1 0 0 1 1 1 0 Periplasmic nitrate reductase protein NapE WLM PF08325.10 ELR21079.1 - 0.00013 22.0 0.7 0.0057 16.7 0.1 2.7 2 1 1 3 3 3 1 WLM domain KHA PF11834.8 ELR21079.1 - 0.0014 18.7 0.0 0.0029 17.7 0.0 1.5 1 0 0 1 1 1 1 KHA, dimerisation domain of potassium ion channel SprT-like PF10263.9 ELR21079.1 - 0.02 14.8 0.4 0.032 14.1 0.4 1.4 1 0 0 1 1 1 0 SprT-like family BROMI PF14961.6 ELR21080.1 - 0.11 9.8 0.0 0.14 9.5 0.0 1.0 1 0 0 1 1 1 0 Broad-minded protein SPRY PF00622.28 ELR21081.1 - 1.7e-17 63.6 0.1 6.6e-17 61.7 0.1 1.9 1 1 0 1 1 1 1 SPRY domain BUD22 PF09073.10 ELR21081.1 - 0.036 13.4 15.5 0.06 12.7 15.5 1.2 1 0 0 1 1 1 0 BUD22 CAAD PF14159.6 ELR21081.1 - 0.11 12.4 0.0 0.89 9.4 0.0 2.4 3 0 0 3 3 3 0 CAAD domains of cyanobacterial aminoacyl-tRNA synthetase NARP1 PF12569.8 ELR21081.1 - 0.14 11.0 2.8 0.19 10.6 2.8 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 FYDLN_acid PF09538.10 ELR21081.1 - 0.15 12.8 10.8 0.33 11.7 10.8 1.6 1 0 0 1 1 1 0 Protein of unknown function (FYDLN_acid) RNA_pol_3_Rpc31 PF11705.8 ELR21081.1 - 0.18 12.1 16.4 0.3 11.3 16.4 1.3 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 Vfa1 PF08432.10 ELR21081.1 - 0.35 11.2 6.0 0.6 10.4 6.0 1.3 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Cwf_Cwc_15 PF04889.12 ELR21081.1 - 0.46 10.2 19.5 0.75 9.5 19.5 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein SDA1 PF05285.12 ELR21081.1 - 2.3 7.6 16.9 3.4 7.0 16.9 1.2 1 0 0 1 1 1 0 SDA1 Myc_N PF01056.18 ELR21081.1 - 2.3 8.0 6.7 3.8 7.3 6.7 1.2 1 0 0 1 1 1 0 Myc amino-terminal region RXT2_N PF08595.11 ELR21081.1 - 3.4 7.7 9.7 6.9 6.7 9.7 1.5 1 0 0 1 1 1 0 RXT2-like, N-terminal Nop53 PF07767.11 ELR21081.1 - 4.5 6.6 17.5 6.7 6.0 17.5 1.2 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) Pox_Ag35 PF03286.14 ELR21081.1 - 7.3 6.3 10.3 13 5.5 10.3 1.3 1 0 0 1 1 1 0 Pox virus Ag35 surface protein Nop14 PF04147.12 ELR21081.1 - 8.9 4.4 20.6 13 3.9 20.6 1.1 1 0 0 1 1 1 0 Nop14-like family CENP-B_dimeris PF09026.10 ELR21081.1 - 9.4 6.7 17.9 25 5.4 17.9 1.8 1 0 0 1 1 1 0 Centromere protein B dimerisation domain BTB PF00651.31 ELR21082.1 - 6.6e-13 48.9 0.1 1.2e-12 48.0 0.1 1.4 1 0 0 1 1 1 1 BTB/POZ domain Nucleoporin_FG PF13634.6 ELR21082.1 - 1.2 10.1 115.0 7.7 7.4 23.0 5.4 1 1 1 2 2 2 0 Nucleoporin FG repeat region PH PF00169.29 ELR21083.1 - 4.4e-09 36.8 0.0 1.3e-08 35.3 0.0 1.8 1 0 0 1 1 1 1 PH domain PH_3 PF14593.6 ELR21083.1 - 5.5e-06 26.4 0.4 0.0059 16.7 0.0 3.1 3 0 0 3 3 3 2 PH domain PH_8 PF15409.6 ELR21083.1 - 0.01 16.1 0.2 12 6.2 0.0 3.2 3 0 0 3 3 3 0 Pleckstrin homology domain PH_2 PF08458.10 ELR21083.1 - 0.023 15.1 0.2 0.34 11.3 0.0 2.8 2 0 0 2 2 2 0 Plant pleckstrin homology-like region PH_12 PF16457.5 ELR21083.1 - 0.028 15.0 5.5 0.085 13.4 0.0 3.4 3 1 0 3 3 3 0 Pleckstrin homology domain Ank_2 PF12796.7 ELR21084.1 - 2.3e-10 40.9 0.3 5.9e-07 30.0 0.1 2.5 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.30 ELR21084.1 - 6.9e-09 35.8 5.2 0.0043 17.4 0.6 3.6 3 0 0 3 3 3 3 Ankyrin repeat Ank_4 PF13637.6 ELR21084.1 - 3.6e-08 33.8 2.1 0.13 12.9 0.0 4.3 2 1 2 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 ELR21084.1 - 4.3e-08 32.8 1.1 0.69 10.7 0.0 3.6 3 0 0 3 3 3 3 Ankyrin repeat Ank_5 PF13857.6 ELR21084.1 - 1.6e-05 25.0 1.8 0.092 13.1 0.0 3.5 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Methyltransf_16 PF10294.9 ELR21085.1 - 1.7e-17 63.7 0.0 2.6e-17 63.1 0.0 1.2 1 0 0 1 1 1 1 Lysine methyltransferase DUF3021 PF11457.8 ELR21085.1 - 0.18 12.1 0.0 0.3 11.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3021) MTS PF05175.14 ELR21085.1 - 0.19 11.2 0.0 0.29 10.7 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain FANCI_S1 PF14675.6 ELR21086.1 - 1.9e-10 40.7 0.0 3.8e-10 39.7 0.0 1.5 1 0 0 1 1 1 1 FANCI solenoid 1 DUF4778 PF16008.5 ELR21086.1 - 0.05 13.7 0.4 0.071 13.2 0.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4778) FANCI_S4 PF14678.6 ELR21087.1 - 1e-50 172.2 3.2 4.1e-50 170.3 3.5 1.9 2 0 0 2 2 2 1 FANCI solenoid 4 FANCI_HD2 PF14680.6 ELR21087.1 - 3.7e-45 154.0 2.2 3.7e-45 154.0 2.2 2.8 2 1 1 3 3 3 1 FANCI helical domain 2 FANCI_S2 PF14676.6 ELR21087.1 - 8.1e-43 146.6 0.4 8.1e-43 146.6 0.4 3.9 4 1 0 4 4 4 1 FANCI solenoid 2 FANCI_S1 PF14675.6 ELR21087.1 - 2.6e-14 53.3 0.2 1.2e-13 51.1 0.0 2.3 2 0 0 2 2 2 1 FANCI solenoid 1 FANCI_HD1 PF14679.6 ELR21087.1 - 1e-13 51.1 4.8 7.9e-13 48.2 0.8 4.2 3 1 0 3 3 3 1 FANCI helical domain 1 RNase_HII PF01351.18 ELR21088.1 - 2.4e-50 171.1 0.0 3.1e-50 170.8 0.0 1.1 1 0 0 1 1 1 1 Ribonuclease HII Hydrolase_4 PF12146.8 ELR21089.1 - 0.018 14.3 0.1 1.8 7.8 0.0 2.6 2 1 0 2 2 2 0 Serine aminopeptidase, S33 Peptidase_S9 PF00326.21 ELR21089.1 - 0.13 11.7 0.0 0.39 10.2 0.0 1.7 1 1 0 1 1 1 0 Prolyl oligopeptidase family ANAPC5 PF12862.7 ELR21090.1 - 4.7e-18 65.0 7.2 5e-16 58.6 1.6 4.5 2 2 0 2 2 2 1 Anaphase-promoting complex subunit 5 TPR_7 PF13176.6 ELR21090.1 - 2.3e-05 24.1 0.4 6.5 7.0 0.0 5.2 5 0 0 5 5 4 2 Tetratricopeptide repeat TPR_4 PF07721.14 ELR21090.1 - 5e-05 23.5 5.5 17 6.4 0.0 6.8 6 1 1 7 7 7 0 Tetratricopeptide repeat TPR_12 PF13424.6 ELR21090.1 - 0.00012 22.3 22.0 0.14 12.4 0.1 7.4 5 2 2 7 7 7 3 Tetratricopeptide repeat TPR_2 PF07719.17 ELR21090.1 - 0.00017 21.4 0.9 14 6.1 0.0 6.8 8 0 0 8 8 8 1 Tetratricopeptide repeat TPR_MalT PF17874.1 ELR21090.1 - 0.00034 20.1 12.4 0.00034 20.1 12.4 1.7 2 0 0 2 2 2 1 MalT-like TPR region TPR_14 PF13428.6 ELR21090.1 - 0.0015 19.2 5.6 12 7.0 0.0 7.2 9 1 1 10 10 8 1 Tetratricopeptide repeat TPR_15 PF13429.6 ELR21090.1 - 0.017 14.4 0.3 0.57 9.3 0.0 2.9 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_19 PF14559.6 ELR21090.1 - 0.028 14.9 9.2 2.8 8.5 0.0 5.3 4 1 2 6 6 5 0 Tetratricopeptide repeat zf-C5HC2 PF02928.16 ELR21090.1 - 0.051 14.0 0.3 0.23 11.9 0.3 2.2 1 0 0 1 1 1 0 C5HC2 zinc finger CSD2 PF17876.1 ELR21090.1 - 0.17 12.1 0.0 2.3 8.4 0.0 2.8 3 0 0 3 3 3 0 Cold shock domain TPR_6 PF13174.6 ELR21090.1 - 0.29 11.9 7.7 28 5.6 0.0 6.7 8 1 1 9 9 8 0 Tetratricopeptide repeat TPR_21 PF09976.9 ELR21090.1 - 0.69 9.6 6.5 0.13 12.0 0.2 2.7 2 1 1 3 3 3 0 Tetratricopeptide repeat-like domain F-box-like PF12937.7 ELR21091.1 - 8.4e-05 22.4 0.5 8.4e-05 22.4 0.5 2.6 2 0 0 2 2 2 1 F-box-like LRR_6 PF13516.6 ELR21091.1 - 0.003 17.5 3.7 3.6 7.9 0.1 4.9 5 0 0 5 5 5 1 Leucine Rich repeat LRR_4 PF12799.7 ELR21091.1 - 0.0066 16.8 16.2 5 7.7 1.0 5.9 3 1 2 6 6 6 2 Leucine Rich repeats (2 copies) F-box PF00646.33 ELR21091.1 - 0.033 14.1 2.4 0.28 11.1 1.3 3.0 2 1 0 2 2 2 0 F-box domain DUF3710 PF12502.8 ELR21091.1 - 0.18 11.5 0.8 0.77 9.4 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3710) LRR_1 PF00560.33 ELR21091.1 - 0.42 11.3 7.4 16 6.5 0.1 4.2 4 0 0 4 4 4 0 Leucine Rich Repeat LRR_8 PF13855.6 ELR21091.1 - 1.7 8.5 7.1 7.8 6.3 0.2 4.0 4 1 0 4 4 4 0 Leucine rich repeat F-box-like PF12937.7 ELR21092.1 - 0.0071 16.2 0.1 0.015 15.1 0.1 1.6 1 1 0 1 1 1 1 F-box-like LRR_4 PF12799.7 ELR21093.1 - 0.00018 21.8 4.0 0.017 15.6 0.0 3.2 2 1 1 3 3 3 2 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 ELR21093.1 - 0.088 12.9 3.2 0.18 11.9 0.2 3.3 4 0 0 4 4 4 0 Leucine Rich repeat FNIP PF05725.12 ELR21093.1 - 0.45 10.7 4.5 7.5e+02 0.4 0.0 4.2 3 1 0 3 3 3 0 FNIP Repeat EF-hand_1 PF00036.32 ELR21094.1 - 4.1e-23 79.2 0.3 2.3e-06 26.7 0.0 3.3 3 0 0 3 3 3 3 EF hand EF-hand_7 PF13499.6 ELR21094.1 - 2.8e-22 78.9 0.2 2.7e-13 50.2 0.0 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 ELR21094.1 - 1.3e-20 71.5 0.6 3.2e-05 23.5 0.0 3.3 3 0 0 3 3 3 3 EF-hand domain EF-hand_8 PF13833.6 ELR21094.1 - 4.5e-15 55.2 0.3 0.00084 19.1 0.1 3.3 2 2 1 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.6 ELR21094.1 - 7.2e-15 53.7 0.9 0.00095 18.6 0.2 3.3 3 0 0 3 3 3 3 EF hand EF-hand_11 PF08976.11 ELR21094.1 - 0.00046 21.0 0.0 1.1 10.2 0.0 2.1 1 1 1 2 2 2 2 EF-hand domain YcxB PF14317.6 ELR21094.1 - 0.0029 17.3 1.1 0.08 12.7 0.2 2.3 2 0 0 2 2 2 1 YcxB-like protein DUF5580 PF17743.1 ELR21094.1 - 0.013 14.1 0.0 0.015 13.9 0.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5580) BTRD1 PF17660.1 ELR21094.1 - 0.058 13.2 0.2 0.64 9.9 0.0 2.3 2 0 0 2 2 2 0 Bacterial tandem repeat domain 1 NinG PF05766.12 ELR21094.1 - 0.088 12.7 0.1 0.18 11.7 0.1 1.4 1 0 0 1 1 1 0 Bacteriophage Lambda NinG protein PMBR PF09373.10 ELR21094.1 - 0.11 12.7 0.2 9.8 6.5 0.0 2.9 3 0 0 3 3 3 0 Pseudomurein-binding repeat cNMP_binding PF00027.29 ELR21095.1 - 9.5e-09 35.2 0.0 1.9e-08 34.2 0.0 1.6 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain LRR_6 PF13516.6 ELR21096.1 - 5.2e-07 29.2 1.2 0.13 12.4 0.1 3.5 3 0 0 3 3 3 2 Leucine Rich repeat LRR_8 PF13855.6 ELR21096.1 - 2.7e-05 23.8 0.0 0.013 15.2 0.1 3.2 3 0 0 3 3 3 1 Leucine rich repeat LRR_4 PF12799.7 ELR21096.1 - 0.0022 18.3 1.4 0.094 13.2 1.0 2.8 2 1 0 2 2 2 1 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 ELR21096.1 - 0.0032 17.8 1.7 22 6.1 0.0 3.7 3 0 0 3 3 3 2 Leucine Rich Repeat NIF PF03031.18 ELR21097.1 - 6.5e-24 84.5 0.0 9.9e-24 83.9 0.0 1.3 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase Suc_Fer-like PF06999.12 ELR21098.1 - 5.1e-39 134.2 0.0 6.1e-39 133.9 0.0 1.1 1 0 0 1 1 1 1 Sucrase/ferredoxin-like tRNA-synt_1 PF00133.22 ELR21099.1 - 7.9e-190 632.1 0.0 2.8e-177 590.6 0.0 2.4 1 1 1 2 2 2 2 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 ELR21099.1 - 4.7e-29 101.3 0.1 8e-29 100.6 0.1 1.3 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.11 ELR21099.1 - 9.6e-07 27.9 0.0 0.23 10.2 0.0 3.3 3 0 0 3 3 3 3 tRNA synthetases class I (M) tRNA-synt_1e PF01406.19 ELR21099.1 - 0.015 14.7 0.0 0.04 13.3 0.0 1.7 2 0 0 2 2 2 0 tRNA synthetases class I (C) catalytic domain 3Beta_HSD PF01073.19 ELR21100.1 - 4.8e-61 206.2 0.1 1.8e-59 201.0 0.0 2.0 1 1 1 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 ELR21100.1 - 3.7e-25 88.8 0.0 5.5e-25 88.2 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 ELR21100.1 - 5.3e-16 58.6 0.0 7.6e-16 58.1 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein GDP_Man_Dehyd PF16363.5 ELR21100.1 - 1.5e-14 54.2 0.0 1.5e-13 50.9 0.0 2.2 2 1 0 2 2 2 1 GDP-mannose 4,6 dehydratase RmlD_sub_bind PF04321.17 ELR21100.1 - 1.8e-12 47.0 0.0 2.7e-12 46.4 0.0 1.3 1 0 0 1 1 1 1 RmlD substrate binding domain NAD_binding_10 PF13460.6 ELR21100.1 - 1.5e-11 44.5 0.0 2.4e-11 43.9 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding NAD_binding_4 PF07993.12 ELR21100.1 - 8e-10 38.3 1.4 3.8e-09 36.1 1.4 1.9 1 1 0 1 1 1 1 Male sterility protein KR PF08659.10 ELR21100.1 - 4.6e-08 33.2 0.0 9.3e-08 32.2 0.0 1.5 1 1 0 1 1 1 1 KR domain NmrA PF05368.13 ELR21100.1 - 4.9e-08 32.8 0.0 7.9e-08 32.1 0.0 1.3 1 0 0 1 1 1 1 NmrA-like family adh_short PF00106.25 ELR21100.1 - 0.00039 19.9 0.0 0.00082 18.9 0.0 1.5 1 0 0 1 1 1 1 short chain dehydrogenase DSPc PF00782.20 ELR21101.1 - 3.1e-06 27.1 0.0 3.7e-06 26.8 0.0 1.1 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain DUF667 PF05018.13 ELR21102.1 - 4.7e-76 254.6 0.0 5.3e-76 254.5 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF667) Methyltransf_25 PF13649.6 ELR21103.1 - 1.4e-13 51.4 0.0 3.1e-13 50.2 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ELR21103.1 - 9.8e-11 42.2 0.0 2.2e-10 41.0 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ELR21103.1 - 6.8e-10 38.9 0.0 1.3e-09 38.0 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 ELR21103.1 - 9.3e-09 35.1 0.1 1.4e-08 34.5 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_23 PF13489.6 ELR21103.1 - 1e-08 35.2 0.0 1.9e-07 31.0 0.0 2.3 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_9 PF08003.11 ELR21103.1 - 8.8e-06 24.9 0.0 1.3e-05 24.3 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) Methyltransf_12 PF08242.12 ELR21103.1 - 2.8e-05 24.8 0.0 6.1e-05 23.7 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.7 ELR21103.1 - 3.3e-05 23.8 0.3 5.8e-05 23.1 0.3 1.3 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 ELR21103.1 - 0.00018 21.1 0.1 0.00032 20.3 0.1 1.4 1 0 0 1 1 1 1 Methyltransferase small domain Ubie_methyltran PF01209.18 ELR21103.1 - 0.00052 19.4 0.0 0.00075 18.9 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family PCMT PF01135.19 ELR21103.1 - 0.0021 17.8 0.1 0.0033 17.2 0.1 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) CMAS PF02353.20 ELR21103.1 - 0.0033 16.8 0.0 0.0044 16.4 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase TehB PF03848.14 ELR21103.1 - 0.0044 16.4 0.1 0.0089 15.5 0.1 1.5 1 1 0 1 1 1 1 Tellurite resistance protein TehB FtsJ PF01728.19 ELR21103.1 - 0.0092 16.1 0.1 0.02 15.0 0.0 1.6 2 0 0 2 2 2 1 FtsJ-like methyltransferase Methyltransf_32 PF13679.6 ELR21103.1 - 0.016 15.2 0.0 0.031 14.2 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_2 PF00891.18 ELR21103.1 - 0.016 14.5 0.1 0.03 13.6 0.1 1.4 1 0 0 1 1 1 0 O-methyltransferase domain Methyltransf_24 PF13578.6 ELR21103.1 - 0.018 16.0 0.0 0.042 14.9 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_16 PF10294.9 ELR21103.1 - 0.13 12.0 0.2 0.19 11.5 0.2 1.3 1 0 0 1 1 1 0 Lysine methyltransferase Polyketide_cyc2 PF10604.9 ELR21104.1 - 6.4e-09 36.2 0.1 6.8e-09 36.1 0.1 1.0 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport SseB PF07179.12 ELR21105.1 - 6.8e-07 29.6 0.2 1.1e-06 29.0 0.2 1.3 1 0 0 1 1 1 1 SseB protein N-terminal domain Erythro_esteras PF05139.14 ELR21106.1 - 1.9e-105 353.5 6.2 2.4e-105 353.2 6.2 1.1 1 0 0 1 1 1 1 Erythromycin esterase Aminotran_1_2 PF00155.21 ELR21107.1 - 6.5e-39 134.1 0.0 8.7e-39 133.7 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Alliinase_C PF04864.13 ELR21107.1 - 0.0072 15.2 0.0 0.011 14.6 0.0 1.2 1 0 0 1 1 1 1 Allinase Aminotran_5 PF00266.19 ELR21107.1 - 0.025 13.5 0.0 0.044 12.7 0.0 1.3 1 0 0 1 1 1 0 Aminotransferase class-V Tmemb_161AB PF10268.9 ELR21109.1 - 0.11 11.1 0.0 0.13 10.9 0.0 1.1 1 0 0 1 1 1 0 Predicted transmembrane protein 161AB Thymopoietin PF08198.11 ELR21109.1 - 0.2 11.3 0.0 0.34 10.6 0.0 1.3 1 0 0 1 1 1 0 Thymopoietin protein Pro_isomerase PF00160.21 ELR21110.1 - 2.1e-44 151.6 0.0 3.6e-44 150.8 0.0 1.4 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD RRM_1 PF00076.22 ELR21110.1 - 1.5e-14 53.6 0.0 4.1e-14 52.2 0.0 1.8 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SAPS PF04499.15 ELR21110.1 - 1.7 7.3 3.5 2.4 6.8 3.5 1.3 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein CoaE PF01121.20 ELR21111.1 - 3.1e-41 141.0 0.1 3.9e-41 140.7 0.1 1.1 1 0 0 1 1 1 1 Dephospho-CoA kinase AAA_18 PF13238.6 ELR21111.1 - 2.4e-05 24.9 0.6 0.0003 21.4 0.5 2.3 1 1 1 2 2 2 1 AAA domain AAA_33 PF13671.6 ELR21111.1 - 0.00013 22.2 0.3 0.0014 18.8 0.3 2.6 1 1 1 2 2 2 1 AAA domain APS_kinase PF01583.20 ELR21111.1 - 0.004 17.1 0.2 0.011 15.6 0.1 1.8 2 0 0 2 2 2 1 Adenylylsulphate kinase Zeta_toxin PF06414.12 ELR21111.1 - 0.0063 15.8 0.7 0.026 13.8 0.0 2.0 2 0 0 2 2 2 1 Zeta toxin ANTAR PF03861.14 ELR21111.1 - 0.0086 15.9 0.1 0.022 14.6 0.0 1.7 2 0 0 2 2 2 1 ANTAR domain dNK PF01712.19 ELR21111.1 - 0.017 15.0 0.1 0.16 11.8 0.0 2.1 2 1 0 2 2 2 0 Deoxynucleoside kinase AAA_28 PF13521.6 ELR21111.1 - 0.044 14.0 4.1 2.1 8.6 4.1 2.5 1 1 0 1 1 1 0 AAA domain KTI12 PF08433.10 ELR21111.1 - 0.058 12.8 0.1 0.13 11.6 0.0 1.6 2 0 0 2 2 2 0 Chromatin associated protein KTI12 DUF87 PF01935.17 ELR21111.1 - 0.063 13.4 0.5 0.41 10.7 0.2 2.0 2 0 0 2 2 2 0 Helicase HerA, central domain PRK PF00485.18 ELR21111.1 - 0.084 12.6 0.0 0.16 11.7 0.0 1.5 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family SKI PF01202.22 ELR21111.1 - 0.088 12.9 0.2 4.8 7.3 0.0 2.2 2 0 0 2 2 2 0 Shikimate kinase Cytidylate_kin2 PF13189.6 ELR21111.1 - 0.091 12.9 1.0 0.8 9.8 1.0 2.2 1 1 0 1 1 1 0 Cytidylate kinase-like family CLP1_P PF16575.5 ELR21111.1 - 0.095 12.5 0.0 5.4 6.8 0.0 2.2 2 0 0 2 2 2 0 mRNA cleavage and polyadenylation factor CLP1 P-loop BCA_ABC_TP_C PF12399.8 ELR21111.1 - 0.14 12.2 0.2 1.4 8.9 0.1 2.3 2 0 0 2 2 2 0 Branched-chain amino acid ATP-binding cassette transporter Ependymin PF00811.18 ELR21112.1 - 0.025 14.9 0.0 0.042 14.1 0.0 1.4 1 0 0 1 1 1 0 Ependymin V-SNARE_C PF12352.8 ELR21113.1 - 2.2e-05 24.6 0.8 0.00027 21.2 0.1 2.3 2 0 0 2 2 2 1 Snare region anchored in the vesicle membrane C-terminus DUF16 PF01519.16 ELR21113.1 - 0.088 13.3 2.4 0.81 10.2 1.4 2.2 2 0 0 2 2 2 0 Protein of unknown function DUF16 Laminin_II PF06009.12 ELR21113.1 - 0.2 11.7 2.9 4.9 7.2 1.5 2.3 2 0 0 2 2 2 0 Laminin Domain II DUF5089 PF17002.5 ELR21113.1 - 0.38 10.6 12.1 81 3.0 12.1 2.5 1 1 0 1 1 1 0 Domain of unknown function (DUF5089) Fib_alpha PF08702.10 ELR21113.1 - 0.68 10.1 3.8 0.44 10.7 1.4 1.8 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family Spc7 PF08317.11 ELR21113.1 - 0.81 8.5 7.9 0.32 9.8 2.2 2.0 2 0 0 2 2 2 0 Spc7 kinetochore protein KASH_CCD PF14662.6 ELR21113.1 - 0.89 9.3 8.4 0.85 9.4 1.4 2.2 2 0 0 2 2 2 0 Coiled-coil region of CCDC155 or KASH TMF_TATA_bd PF12325.8 ELR21113.1 - 1 9.6 8.3 1.9 8.7 0.5 2.3 2 0 0 2 2 2 0 TATA element modulatory factor 1 TATA binding BST2 PF16716.5 ELR21113.1 - 3.4 8.3 7.5 17 6.0 2.0 2.4 2 0 0 2 2 2 0 Bone marrow stromal antigen 2 Alb1 PF09135.11 ELR21113.1 - 3.6 8.5 14.2 5.2 8.0 3.2 2.7 3 0 0 3 3 3 0 Alb1 APG6_N PF17675.1 ELR21113.1 - 4.1 8.0 8.5 1.8 9.1 1.0 2.2 2 0 0 2 2 2 0 Apg6 coiled-coil region DUF4407 PF14362.6 ELR21113.1 - 7.9 5.7 6.7 6.8 5.9 0.4 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) Recep_L_domain PF01030.24 ELR21114.1 - 1.4e-12 47.7 18.8 0.0029 17.7 0.9 5.9 1 1 5 6 6 6 6 Receptor L domain stn_TNFRSF12A PF12191.8 ELR21114.1 - 0.037 14.3 0.5 0.072 13.3 0.5 1.4 1 0 0 1 1 1 0 Tumour necrosis factor receptor stn_TNFRSF12A_TNFR domain LRR_9 PF14580.6 ELR21114.1 - 0.29 10.6 11.9 0.64 9.5 0.4 3.6 3 1 2 5 5 5 0 Leucine-rich repeat DUF773 PF05600.12 ELR21116.1 - 5e-122 408.2 9.7 5.1e-121 404.9 9.7 1.9 1 1 0 1 1 1 1 CDK5 regulatory subunit-associated protein 3 Cbl_N PF02262.16 ELR21116.1 - 0.024 14.6 0.4 0.46 10.5 0.2 2.4 2 0 0 2 2 2 0 CBL proto-oncogene N-terminal domain 1 Sec34 PF04136.15 ELR21116.1 - 0.11 12.4 6.5 0.42 10.5 1.2 3.2 3 1 0 3 3 3 0 Sec34-like family FliD_C PF07195.12 ELR21116.1 - 0.32 10.4 3.0 10 5.4 0.1 2.6 2 1 0 2 2 2 0 Flagellar hook-associated protein 2 C-terminus Lebercilin PF15619.6 ELR21116.1 - 0.45 10.1 12.4 1.6 8.3 0.0 3.4 3 1 0 3 3 3 0 Ciliary protein causing Leber congenital amaurosis disease RNase_H PF00075.24 ELR21116.1 - 1.7 8.8 4.2 15 5.7 0.0 3.2 3 0 0 3 3 3 0 RNase H COG5 PF10392.9 ELR21116.1 - 2.9 8.1 8.5 2.7 8.2 4.1 2.7 2 1 0 2 2 2 0 Golgi transport complex subunit 5 COMPASS-Shg1 PF05205.12 ELR21116.1 - 3.4 8.4 6.2 1.5 9.5 3.2 2.0 2 0 0 2 2 2 0 COMPASS (Complex proteins associated with Set1p) component shg1 IFT20 PF14931.6 ELR21116.1 - 3.5 7.8 7.1 0.95 9.6 2.0 2.6 2 1 0 2 2 2 0 Intraflagellar transport complex B, subunit 20 DUF3053 PF11254.8 ELR21116.1 - 5.3 6.6 9.0 0.39 10.3 1.2 2.5 2 1 1 3 3 3 0 Protein of unknown function (DUF3053) Fzo_mitofusin PF04799.13 ELR21116.1 - 6.4 6.3 9.3 5.7 6.5 0.6 3.5 2 2 1 3 3 3 0 fzo-like conserved region DUF148 PF02520.17 ELR21116.1 - 7.5 6.7 10.2 2.1 8.5 0.0 3.5 3 1 0 3 3 3 0 Domain of unknown function DUF148 DUF924 PF06041.11 ELR21117.1 - 7.3e-37 127.2 0.9 1.4e-36 126.3 0.9 1.4 1 1 0 1 1 1 1 Bacterial protein of unknown function (DUF924) eIF_4EBP PF05456.11 ELR21118.1 - 2.4e-30 104.8 0.8 2.7e-30 104.7 0.8 1.1 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 4E binding protein (EIF4EBP) BolA PF01722.18 ELR21119.1 - 6.4e-28 96.9 0.3 7.8e-28 96.6 0.3 1.1 1 0 0 1 1 1 1 BolA-like protein RWP-RK PF02042.15 ELR21120.1 - 0.00022 21.1 1.3 0.00031 20.7 0.3 1.7 2 0 0 2 2 2 1 RWP-RK domain HTH_8 PF02954.19 ELR21120.1 - 0.0085 15.9 0.0 0.015 15.0 0.0 1.4 1 0 0 1 1 1 1 Bacterial regulatory protein, Fis family HTH_psq PF05225.16 ELR21120.1 - 0.023 14.4 0.1 0.057 13.2 0.0 1.7 2 0 0 2 2 2 0 helix-turn-helix, Psq domain HTH_3 PF01381.22 ELR21120.1 - 0.054 13.6 0.0 0.12 12.5 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix HTH_23 PF13384.6 ELR21120.1 - 0.069 13.0 0.0 0.14 12.0 0.0 1.4 1 0 0 1 1 1 0 Homeodomain-like domain ANAPC1 PF12859.7 ELR21121.1 - 6.3e-11 42.9 0.9 2.7e-07 31.2 0.0 2.8 1 1 1 2 2 2 2 Anaphase-promoting complex subunit 1 APC1_C PF18122.1 ELR21121.1 - 0.0013 18.7 0.0 0.0026 17.7 0.0 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex sub unit 1 C-terminal domain PC_rep PF01851.22 ELR21121.1 - 0.093 13.2 9.2 6.7 7.3 0.0 5.6 5 0 0 5 5 5 0 Proteasome/cyclosome repeat Glyco_transf_49 PF13896.6 ELR21122.1 - 3.3e-17 62.9 0.0 2.1e-08 33.9 0.0 2.5 1 1 1 2 2 2 2 Glycosyl-transferase for dystroglycan LRR_8 PF13855.6 ELR21124.1 - 3e-39 132.6 29.7 2e-09 37.1 0.3 6.8 2 2 5 7 7 7 7 Leucine rich repeat LRR_4 PF12799.7 ELR21124.1 - 4.7e-30 103.1 38.5 2.5e-05 24.6 0.1 8.6 3 1 6 10 10 10 10 Leucine Rich repeats (2 copies) Filamin PF00630.19 ELR21124.1 - 1.6e-24 86.7 0.0 3e-14 53.7 0.0 2.3 2 0 0 2 2 2 2 Filamin/ABP280 repeat LRR_1 PF00560.33 ELR21124.1 - 2.9e-10 39.2 26.7 3.2 8.7 0.1 12.0 13 1 0 13 13 13 3 Leucine Rich Repeat LRR_9 PF14580.6 ELR21124.1 - 1.4e-07 31.2 12.6 0.074 12.5 0.4 4.4 1 1 3 4 4 4 4 Leucine-rich repeat LRR_5 PF13306.6 ELR21124.1 - 0.00013 21.9 0.1 0.017 15.1 0.3 2.6 2 1 0 2 2 2 1 BspA type Leucine rich repeat region (6 copies) Invasin_D3 PF09134.10 ELR21124.1 - 0.00021 21.6 0.1 0.02 15.2 0.2 2.4 2 0 0 2 2 2 1 Invasin, domain 3 LRR_6 PF13516.6 ELR21124.1 - 0.00046 20.0 39.3 4.1 7.7 0.1 11.2 12 0 0 12 12 12 3 Leucine Rich repeat RsmF_methylt_CI PF17126.5 ELR21124.1 - 0.041 13.9 0.1 23 5.1 0.0 3.8 4 0 0 4 4 4 0 RsmF rRNA methyltransferase first C-terminal domain CH PF00307.31 ELR21125.1 - 1e-29 102.9 0.0 1.3e-14 54.3 0.0 2.6 2 0 0 2 2 2 2 Calponin homology (CH) domain Transket_pyr PF02779.24 ELR21126.1 - 1.1e-62 210.9 0.0 2.2e-62 209.9 0.0 1.6 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain E1_dh PF00676.20 ELR21126.1 - 2.1e-56 191.1 0.0 3.7e-56 190.3 0.0 1.3 1 0 0 1 1 1 1 Dehydrogenase E1 component OxoGdeHyase_C PF16870.5 ELR21126.1 - 2.4e-40 137.7 0.0 9.1e-40 135.8 0.0 2.1 1 1 0 1 1 1 1 2-oxoglutarate dehydrogenase C-terminal NADH_4Fe-4S PF10589.9 ELR21127.1 - 0.024 14.7 0.3 2.1 8.5 0.1 2.6 2 0 0 2 2 2 0 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region Pkinase_Tyr PF07714.17 ELR21128.1 - 4.9e-109 363.6 0.0 2.5e-56 190.9 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 ELR21128.1 - 9.8e-101 336.5 0.1 2e-51 174.9 0.0 2.4 3 0 0 3 3 3 2 Protein kinase domain Pkinase_fungal PF17667.1 ELR21128.1 - 1e-12 47.6 5.0 1.8e-06 27.0 0.0 3.2 3 0 0 3 3 3 2 Fungal protein kinase Kdo PF06293.14 ELR21128.1 - 4.9e-08 32.6 0.0 0.0035 16.7 0.0 2.4 2 0 0 2 2 2 2 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 ELR21128.1 - 0.00086 18.7 0.0 0.32 10.3 0.0 3.3 3 0 0 3 3 3 1 Kinase-like APH PF01636.23 ELR21128.1 - 0.0094 15.9 0.6 2.9 7.8 0.0 2.5 2 0 0 2 2 2 2 Phosphotransferase enzyme family RR_TM4-6 PF06459.12 ELR21128.1 - 8.4 6.1 13.4 14 5.4 13.4 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Peptidase_S49_N PF08496.10 ELR21128.1 - 9.3 6.3 12.9 18 5.4 12.9 1.4 1 0 0 1 1 1 0 Peptidase family S49 N-terminal RGS PF00615.19 ELR21129.1 - 3.8e-22 78.8 0.7 7e-22 77.9 0.7 1.4 1 0 0 1 1 1 1 Regulator of G protein signaling domain SLC12 PF03522.15 ELR21129.1 - 0.23 10.5 5.2 0.33 9.9 5.2 1.3 1 0 0 1 1 1 0 Solute carrier family 12 DUF4345 PF14248.6 ELR21130.1 - 0.027 14.4 0.4 0.027 14.4 0.4 2.9 2 1 1 3 3 3 0 Domain of unknown function (DUF4345) DUF202 PF02656.15 ELR21130.1 - 8.3 6.9 9.1 2.6 8.5 0.0 3.4 1 1 1 2 2 2 0 Domain of unknown function (DUF202) NUDIX PF00293.28 ELR21131.1 - 2.6e-08 34.0 0.0 3.3e-08 33.6 0.0 1.1 1 0 0 1 1 1 1 NUDIX domain LcrG PF07216.12 ELR21131.1 - 0.21 11.5 0.0 0.44 10.5 0.0 1.5 1 0 0 1 1 1 0 LcrG protein RhoGAP PF00620.27 ELR21132.1 - 3.2e-30 105.0 0.1 4.3e-30 104.5 0.1 1.2 1 0 0 1 1 1 1 RhoGAP domain DEP PF00610.21 ELR21133.1 - 4e-15 55.6 0.0 7.5e-15 54.8 0.0 1.5 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) SAM_1 PF00536.30 ELR21134.1 - 5.7e-10 39.5 0.0 9.5e-10 38.8 0.0 1.3 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) DZR PF12773.7 ELR21134.1 - 3.2e-07 30.3 20.9 0.012 15.6 0.4 4.3 3 1 1 4 4 4 3 Double zinc ribbon SAM_2 PF07647.17 ELR21134.1 - 9.4e-06 25.7 0.0 1.6e-05 24.9 0.0 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) HypA PF01155.19 ELR21134.1 - 0.00028 20.9 19.4 0.061 13.4 0.3 4.2 3 1 1 4 4 4 3 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zinc_ribbon_2 PF13240.6 ELR21134.1 - 0.0019 17.9 29.5 0.029 14.1 6.6 4.5 4 0 0 4 4 4 2 zinc-ribbon domain zinc_ribbon_15 PF17032.5 ELR21134.1 - 0.0024 18.6 16.3 0.64 10.8 2.0 3.7 3 1 1 4 4 4 2 zinc-ribbon family Zn-C2H2_12 PF18112.1 ELR21134.1 - 0.01 16.3 8.0 0.62 10.6 0.1 3.9 4 0 0 4 4 4 0 Autophagy receptor zinc finger-C2H2 domain NOB1_Zn_bind PF08772.11 ELR21134.1 - 0.045 13.9 0.4 0.045 13.9 0.4 4.4 4 0 0 4 4 4 0 Nin one binding (NOB1) Zn-ribbon like zf-ribbon_3 PF13248.6 ELR21134.1 - 0.18 11.3 32.7 0.94 9.0 1.0 5.9 6 1 0 6 6 6 0 zinc-ribbon domain zf-CHY PF05495.12 ELR21134.1 - 2.2 8.8 17.8 2.2 8.9 0.8 4.1 3 1 1 4 4 4 0 CHY zinc finger YyzF PF14116.6 ELR21134.1 - 4 7.5 6.7 12 6.0 0.4 3.7 3 0 0 3 3 3 0 YyzF-like protein Nudix_N_2 PF14803.6 ELR21134.1 - 7.7 6.5 24.1 5.5 7.0 0.1 6.4 7 0 0 7 7 7 0 Nudix N-terminal DUF382 PF04037.13 ELR21135.1 - 1.9e-59 199.4 0.9 1.9e-59 199.4 0.9 2.6 3 0 0 3 3 3 1 Domain of unknown function (DUF382) PSP PF04046.16 ELR21135.1 - 2.8e-21 75.1 5.8 5.3e-21 74.2 5.8 1.5 1 0 0 1 1 1 1 PSP Yip1 PF04893.17 ELR21136.1 - 6.7e-08 32.4 12.4 1.1e-07 31.8 12.4 1.3 1 0 0 1 1 1 1 Yip1 domain YIF1 PF03878.15 ELR21136.1 - 4.6e-07 29.6 5.9 4.3e-05 23.1 6.0 2.1 1 1 0 1 1 1 1 YIF1 WD40 PF00400.32 ELR21137.1 - 1.1e-50 168.4 21.9 1.8e-09 38.1 0.1 7.3 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ELR21137.1 - 1e-19 70.6 1.2 0.0089 16.3 0.0 6.1 2 1 3 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ELR21137.1 - 4.3e-06 25.7 0.1 0.43 9.2 0.0 4.3 1 1 2 4 4 4 2 Nucleoporin Nup120/160 WD40_like PF17005.5 ELR21137.1 - 9.3e-05 21.9 0.0 1 8.7 0.0 4.1 2 1 3 5 5 5 2 WD40-like domain Ge1_WD40 PF16529.5 ELR21137.1 - 0.00014 21.0 1.8 4.3 6.2 0.0 4.8 3 1 1 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein PALB2_WD40 PF16756.5 ELR21137.1 - 0.00078 18.5 2.3 2.7 6.8 0.0 3.7 3 1 1 4 4 4 2 Partner and localizer of BRCA2 WD40 domain eIF2A PF08662.11 ELR21137.1 - 0.001 19.0 0.2 0.019 14.8 0.1 2.8 1 1 2 3 3 3 1 Eukaryotic translation initiation factor eIF2A Glyco_hyd_65N_2 PF14498.6 ELR21137.1 - 0.008 16.1 0.9 0.11 12.3 0.2 2.2 2 0 0 2 2 2 1 Glycosyl hydrolase family 65, N-terminal domain PYC_OADA PF02436.18 ELR21137.1 - 0.11 12.2 0.3 0.21 11.3 0.3 1.4 1 0 0 1 1 1 0 Conserved carboxylase domain PAE PF03283.13 ELR21138.1 - 2.9e-67 227.3 1.1 3.6e-67 227.0 1.1 1.0 1 0 0 1 1 1 1 Pectinacetylesterase Arch_fla_DE PF04659.13 ELR21138.1 - 0.072 13.0 0.2 0.13 12.1 0.2 1.4 1 0 0 1 1 1 0 Archaeal flagella protein LRR_8 PF13855.6 ELR21139.1 - 9e-07 28.6 0.4 1.6e-06 27.8 0.4 1.4 1 0 0 1 1 1 1 Leucine rich repeat LRR_4 PF12799.7 ELR21139.1 - 0.0059 17.0 1.3 0.19 12.2 1.2 2.4 1 1 2 3 3 3 2 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 ELR21139.1 - 0.021 15.3 1.3 16 6.6 0.1 3.2 3 0 0 3 3 3 0 Leucine Rich Repeat Nudix_N_2 PF14803.6 ELR21139.1 - 0.057 13.3 0.7 0.13 12.2 0.1 1.9 2 0 0 2 2 2 0 Nudix N-terminal LRR_6 PF13516.6 ELR21139.1 - 0.29 11.3 1.1 19 5.6 0.2 2.6 2 0 0 2 2 2 0 Leucine Rich repeat RCC1 PF00415.18 ELR21140.1 - 5.4e-52 174.2 21.4 6.4e-11 42.7 0.2 7.6 7 0 0 7 7 7 7 Regulator of chromosome condensation (RCC1) repeat BTB PF00651.31 ELR21140.1 - 2.5e-33 114.6 0.0 4e-17 62.4 0.0 2.9 2 1 1 3 3 3 2 BTB/POZ domain RCC1_2 PF13540.6 ELR21140.1 - 5e-23 80.3 41.2 3.6e-07 29.8 3.3 6.5 6 0 0 6 6 6 5 Regulator of chromosome condensation (RCC1) repeat VHP PF02209.19 ELR21140.1 - 5.4e-15 55.2 0.6 1.3e-14 54.0 0.6 1.7 1 0 0 1 1 1 1 Villin headpiece domain DUF4213 PF13938.6 ELR21140.1 - 0.11 12.8 1.2 2.6 8.4 0.0 3.6 4 1 0 4 4 4 0 Putative heavy-metal chelation Allexi_40kDa PF05549.11 ELR21140.1 - 0.17 11.3 1.7 1.8 8.0 0.1 2.6 1 1 1 2 2 2 0 Allexivirus 40kDa protein LIM PF00412.22 ELR21141.1 - 2.5e-12 46.8 1.8 3.1e-12 46.5 1.8 1.1 1 0 0 1 1 1 1 LIM domain zf_C2HC_14 PF18574.1 ELR21141.1 - 0.11 12.3 4.5 4.8 7.1 0.7 2.4 2 0 0 2 2 2 0 C2HC Zing finger domain DNA_RNApol_7kD PF03604.13 ELR21141.1 - 0.12 12.0 0.6 0.12 12.0 0.6 2.2 2 0 0 2 2 2 0 DNA directed RNA polymerase, 7 kDa subunit zf_UBZ PF18439.1 ELR21141.1 - 0.4 10.3 2.9 3 7.5 0.6 2.3 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger Chorismate_synt PF01264.21 ELR21143.1 - 1.8e-141 470.6 0.3 2e-141 470.4 0.3 1.0 1 0 0 1 1 1 1 Chorismate synthase IGPS PF00218.21 ELR21144.1 - 8.8e-79 264.3 0.0 1.8e-78 263.2 0.0 1.6 2 0 0 2 2 2 1 Indole-3-glycerol phosphate synthase PRAI PF00697.22 ELR21144.1 - 4.1e-40 137.6 0.2 2.4e-35 122.1 0.1 2.4 2 0 0 2 2 2 2 N-(5'phosphoribosyl)anthranilate (PRA) isomerase Shikimate_dh_N PF08501.11 ELR21144.1 - 2.3e-21 75.8 0.0 7.7e-21 74.2 0.0 2.0 1 0 0 1 1 1 1 Shikimate dehydrogenase substrate binding domain SDH_C PF18317.1 ELR21144.1 - 6.3e-09 35.5 0.0 1.5e-08 34.3 0.0 1.7 1 0 0 1 1 1 1 Shikimate 5'-dehydrogenase C-terminal domain Shikimate_DH PF01488.20 ELR21144.1 - 5e-08 33.1 0.0 1.4e-07 31.6 0.0 1.7 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase AlaDh_PNT_C PF01262.21 ELR21144.1 - 0.00029 20.2 0.0 0.00084 18.7 0.0 1.7 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain QRPTase_C PF01729.19 ELR21144.1 - 0.0003 20.6 0.3 0.048 13.4 0.3 3.3 2 1 0 2 2 2 1 Quinolinate phosphoribosyl transferase, C-terminal domain F420_oxidored PF03807.17 ELR21144.1 - 0.00043 20.8 0.0 0.0022 18.5 0.0 2.4 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent Sacchrp_dh_NADP PF03435.18 ELR21144.1 - 0.0034 17.6 0.0 0.013 15.8 0.0 2.0 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain DUF1611_N PF17396.2 ELR21144.1 - 0.1 12.8 0.2 20 5.5 0.0 2.9 2 0 0 2 2 2 0 Domain of unknown function (DUF1611_N) Rossmann-like domain Pkinase PF00069.25 ELR21145.1 - 1.8e-59 201.3 0.0 6e-59 199.6 0.0 1.7 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR21145.1 - 6e-27 94.5 0.1 2.4e-24 86.1 0.1 2.3 1 1 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 ELR21145.1 - 0.023 14.6 0.1 0.049 13.5 0.1 1.5 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kdo PF06293.14 ELR21145.1 - 0.15 11.4 0.4 1.9 7.8 0.1 2.1 1 1 1 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family DUF2457 PF10446.9 ELR21145.1 - 9.7 5.2 8.6 15 4.6 8.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Glycos_transf_3 PF00591.21 ELR21146.1 - 8.7e-79 264.7 0.1 1.5e-78 263.9 0.1 1.4 1 0 0 1 1 1 1 Glycosyl transferase family, a/b domain GATase PF00117.28 ELR21146.1 - 2.9e-47 160.9 0.0 4.7e-47 160.2 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Chorismate_bind PF00425.18 ELR21146.1 - 3.5e-22 79.2 0.1 5.4e-22 78.6 0.1 1.3 1 0 0 1 1 1 1 chorismate binding enzyme Glycos_trans_3N PF02885.17 ELR21146.1 - 3e-10 39.8 0.1 9.2e-10 38.2 0.1 1.9 1 0 0 1 1 1 1 Glycosyl transferase family, helical bundle domain Peptidase_C26 PF07722.13 ELR21146.1 - 8.3e-07 29.0 0.6 3.3e-06 27.0 0.6 1.9 1 1 0 1 1 1 1 Peptidase C26 BTB PF00651.31 ELR21147.1 - 3.6e-06 27.2 0.2 7.5e-05 22.9 0.0 2.1 1 1 1 2 2 2 1 BTB/POZ domain Raf1_HTH PF18579.1 ELR21147.1 - 0.19 11.5 0.4 16 5.3 0.0 2.3 2 0 0 2 2 2 0 Rubisco accumulation factor 1 helix turn helix domain Chorismate_bind PF00425.18 ELR21148.1 - 1.7e-28 99.9 0.0 2.7e-28 99.3 0.0 1.3 1 0 0 1 1 1 1 chorismate binding enzyme Anth_synt_I_N PF04715.13 ELR21148.1 - 1.7e-14 54.2 0.0 1.5e-13 51.2 0.0 2.4 2 1 0 2 2 2 1 Anthranilate synthase component I, N terminal region Trp_syntA PF00290.20 ELR21149.1 - 1.4e-90 302.7 0.7 6e-90 300.6 0.1 1.9 2 0 0 2 2 2 1 Tryptophan synthase alpha chain PALP PF00291.25 ELR21149.1 - 9e-49 166.5 0.3 1.7e-48 165.6 0.3 1.5 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme His_biosynth PF00977.21 ELR21149.1 - 0.00063 19.3 0.1 0.0029 17.1 0.1 2.0 2 0 0 2 2 2 1 Histidine biosynthesis protein PA PF02225.22 ELR21149.1 - 0.091 12.8 0.0 0.24 11.5 0.0 1.7 1 0 0 1 1 1 0 PA domain Ubie_methyltran PF01209.18 ELR21150.1 - 2.4e-11 43.5 0.0 2.4e-09 36.9 0.0 2.1 2 0 0 2 2 2 2 ubiE/COQ5 methyltransferase family Methyltransf_11 PF08241.12 ELR21150.1 - 5.4e-08 33.4 0.4 1.2e-06 29.1 0.4 2.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ELR21150.1 - 3.7e-07 30.7 0.4 0.00015 22.4 0.2 2.7 2 1 0 2 2 2 1 Methyltransferase domain UPF0020 PF01170.18 ELR21150.1 - 0.016 14.9 0.1 0.057 13.1 0.0 1.8 2 0 0 2 2 2 0 Putative RNA methylase family UPF0020 Methyltransf_23 PF13489.6 ELR21150.1 - 0.042 13.7 0.0 0.055 13.3 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_31 PF13847.6 ELR21150.1 - 0.087 12.6 0.0 0.36 10.6 0.0 2.0 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_20 PF12147.8 ELR21150.1 - 0.093 11.9 0.0 0.13 11.3 0.0 1.2 1 0 0 1 1 1 0 Putative methyltransferase DUF3824 PF12868.7 ELR21152.1 - 0.0042 17.8 1.2 0.0042 17.8 1.2 3.6 4 1 0 4 4 4 1 Domain of unknwon function (DUF3824) LIM PF00412.22 ELR21153.1 - 1.4e-13 50.9 7.8 1.8e-13 50.5 7.8 1.2 1 0 0 1 1 1 1 LIM domain NUDE_C PF04880.13 ELR21153.1 - 0.012 16.1 3.5 0.014 15.9 3.5 1.2 1 0 0 1 1 1 0 NUDE protein, C-terminal conserved region zf_UBZ PF18439.1 ELR21153.1 - 0.039 13.5 1.2 4.1 7.1 0.3 2.3 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger Bap31_Bap29_C PF18035.1 ELR21153.1 - 0.14 12.2 0.5 0.24 11.4 0.5 1.3 1 0 0 1 1 1 0 Bap31/Bap29 cytoplasmic coiled-coil domain DivIC PF04977.15 ELR21153.1 - 2.9 7.7 4.5 0.49 10.2 1.0 1.5 2 0 0 2 2 2 0 Septum formation initiator YEATS PF03366.16 ELR21155.1 - 8.7e-12 44.9 0.1 1.4e-11 44.2 0.1 1.3 1 0 0 1 1 1 1 YEATS family Ank_5 PF13857.6 ELR21155.1 - 0.016 15.5 0.2 0.079 13.3 0.0 2.2 2 0 0 2 2 2 0 Ankyrin repeats (many copies) Fascin PF06268.13 ELR21157.1 - 0.14 12.4 0.0 0.2 11.9 0.0 1.2 1 0 0 1 1 1 0 Fascin domain Acetyltransf_1 PF00583.25 ELR21159.1 - 1.7e-06 28.3 0.0 5.1e-06 26.7 0.0 1.8 2 0 0 2 2 2 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 ELR21159.1 - 0.00044 20.2 0.0 0.0008 19.4 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 ELR21159.1 - 0.00085 19.7 0.0 0.0016 18.8 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 ELR21159.1 - 0.012 15.7 0.0 6 7.0 0.0 2.3 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain BRK PF07533.16 ELR21159.1 - 0.021 14.4 0.3 0.045 13.4 0.3 1.6 1 0 0 1 1 1 0 BRK domain Acetyltransf_CG PF14542.6 ELR21159.1 - 0.18 12.0 0.0 0.37 10.9 0.0 1.5 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase SDA1 PF05285.12 ELR21159.1 - 0.2 11.1 6.2 0.24 10.8 6.2 1.1 1 0 0 1 1 1 0 SDA1 CDC45 PF02724.14 ELR21159.1 - 0.52 8.6 3.5 0.64 8.2 3.5 1.1 1 0 0 1 1 1 0 CDC45-like protein CAF1A PF12253.8 ELR21159.1 - 0.59 10.3 9.8 0.99 9.6 9.8 1.4 1 0 0 1 1 1 0 Chromatin assembly factor 1 subunit A Nop14 PF04147.12 ELR21159.1 - 0.62 8.2 5.5 0.77 7.9 5.5 1.0 1 0 0 1 1 1 0 Nop14-like family SURF2 PF05477.11 ELR21159.1 - 0.75 9.4 6.2 1.1 8.9 6.2 1.1 1 0 0 1 1 1 0 Surfeit locus protein 2 (SURF2) TFIIF_alpha PF05793.12 ELR21159.1 - 2 6.9 9.1 3.7 6.0 9.1 1.3 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Root_cap PF06830.11 ELR21160.1 - 0.16 12.1 0.0 0.26 11.5 0.0 1.3 1 0 0 1 1 1 0 Root cap HPS3_N PF14761.6 ELR21161.1 - 3.6e-22 79.0 0.0 4.3e-22 78.7 0.0 1.0 1 0 0 1 1 1 1 Hermansky-Pudlak syndrome 3 F_actin_cap_B PF01115.17 ELR21162.1 - 2.5e-06 27.3 0.1 3.1e-06 27.0 0.1 1.1 1 0 0 1 1 1 1 F-actin capping protein, beta subunit Mito_carr PF00153.27 ELR21163.1 - 3.1e-53 177.7 3.2 8.1e-22 77.0 0.2 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Tmpp129 PF10272.9 ELR21164.1 - 0.0012 18.2 15.9 0.0014 18.0 15.9 1.1 1 0 0 1 1 1 1 Putative transmembrane protein precursor PK PF00224.21 ELR21165.1 - 9.4e-147 488.4 1.0 1.5e-146 487.8 1.0 1.3 1 0 0 1 1 1 1 Pyruvate kinase, barrel domain PK_C PF02887.16 ELR21165.1 - 8.9e-32 109.8 0.3 2.2e-31 108.5 0.3 1.7 1 0 0 1 1 1 1 Pyruvate kinase, alpha/beta domain HpcH_HpaI PF03328.14 ELR21165.1 - 2.4e-05 23.6 1.0 6.2e-05 22.2 1.0 1.7 1 1 0 1 1 1 1 HpcH/HpaI aldolase/citrate lyase family Ntox5 PF15543.6 ELR21165.1 - 0.13 12.1 0.1 0.8 9.5 0.1 2.2 2 0 0 2 2 2 0 Bacterial toxin 5 Pkinase PF00069.25 ELR21166.1 - 9.1e-15 54.7 0.0 2e-14 53.6 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR21166.1 - 1.2e-11 44.4 0.0 3.8e-11 42.8 0.0 1.8 1 1 0 1 1 1 1 Protein tyrosine kinase zf-C3HC4_3 PF13920.6 ELR21166.1 - 8.7e-07 28.7 11.7 8.7e-07 28.7 11.7 3.9 4 0 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) VPS9 PF02204.18 ELR21166.1 - 2.9e-06 27.5 0.0 1.1e-05 25.6 0.0 1.9 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain Prok-RING_4 PF14447.6 ELR21166.1 - 0.00012 21.9 10.2 0.00012 21.9 10.2 3.8 3 0 0 3 3 3 1 Prokaryotic RING finger family 4 zf-C3HC4 PF00097.25 ELR21166.1 - 0.002 18.0 13.1 0.002 18.0 13.1 3.3 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 ELR21166.1 - 0.0027 18.0 7.7 0.011 16.0 7.7 2.1 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_2 PF13923.6 ELR21166.1 - 0.0029 17.4 12.6 0.0029 17.4 12.6 3.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 ELR21166.1 - 0.0039 17.5 12.3 0.0039 17.5 12.3 4.0 4 0 0 4 4 4 1 Ring finger domain RsgA_GTPase PF03193.16 ELR21166.1 - 0.028 14.3 0.0 0.83 9.5 0.0 2.4 1 1 1 2 2 2 0 RsgA GTPase AAA_23 PF13476.6 ELR21166.1 - 0.43 11.0 3.5 1.6 9.2 0.0 3.5 4 1 0 4 4 4 0 AAA domain Cys_rich_KTR PF14205.6 ELR21166.1 - 2.3 8.1 5.0 0.77 9.6 0.2 2.8 3 0 0 3 3 3 0 Cysteine-rich KTR zf-RING_4 PF14570.6 ELR21166.1 - 4 7.3 17.0 0.14 12.0 4.9 2.9 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain zf-RING_10 PF16685.5 ELR21166.1 - 7.8 6.7 16.6 0.42 10.8 5.1 2.9 2 0 0 2 2 2 0 zinc RING finger of MSL2 CIMR PF00878.18 ELR21167.1 - 0.00012 22.2 0.4 0.0003 20.9 0.0 1.8 2 0 0 2 2 2 1 Cation-independent mannose-6-phosphate receptor repeat ATG27 PF09451.10 ELR21167.1 - 0.006 16.5 0.0 0.012 15.5 0.0 1.4 1 0 0 1 1 1 1 Autophagy-related protein 27 A_deaminase PF00962.22 ELR21169.1 - 3.7e-09 36.4 0.1 4.5e-09 36.1 0.1 1.1 1 0 0 1 1 1 1 Adenosine/AMP deaminase zf-Di19 PF05605.12 ELR21171.1 - 4.5e-09 36.5 8.2 4.6e-07 30.0 0.0 3.8 3 1 0 3 3 3 1 Drought induced 19 protein (Di19), zinc-binding zf-RING_5 PF14634.6 ELR21171.1 - 0.00011 22.1 16.7 0.00014 21.7 7.7 3.3 3 0 0 3 3 3 1 zinc-RING finger domain zf-RING_2 PF13639.6 ELR21171.1 - 0.00031 21.0 9.8 0.00031 21.0 9.8 3.1 3 0 0 3 3 3 1 Ring finger domain Prok-RING_4 PF14447.6 ELR21171.1 - 0.0012 18.7 16.4 0.0036 17.1 7.8 3.4 3 0 0 3 3 3 1 Prokaryotic RING finger family 4 AAA_11 PF13086.6 ELR21171.1 - 0.0014 18.5 13.1 0.0014 18.5 13.1 2.7 3 0 0 3 3 3 1 AAA domain zf-RING_11 PF17123.5 ELR21171.1 - 0.0041 16.8 7.4 0.0041 16.8 7.4 2.3 3 0 0 3 3 2 1 RING-like zinc finger SVIP PF15811.5 ELR21171.1 - 0.016 15.6 4.1 0.016 15.6 4.1 4.3 3 1 1 4 4 3 0 Small VCP/p97-interacting protein LMBR1 PF04791.16 ELR21171.1 - 0.16 10.9 5.4 0.24 10.2 5.4 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein Vps36-NZF-N PF16988.5 ELR21171.1 - 0.84 9.1 9.5 16 4.9 0.1 4.8 3 1 1 4 4 4 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain zf-Sec23_Sec24 PF04810.15 ELR21171.1 - 1.2 9.2 5.7 20 5.4 0.1 3.5 4 0 0 4 4 4 0 Sec23/Sec24 zinc finger Exonuc_VII_L PF02601.15 ELR21171.1 - 1.7 8.2 20.2 3.3 7.2 20.2 1.4 1 0 0 1 1 1 0 Exonuclease VII, large subunit Allexi_40kDa PF05549.11 ELR21171.1 - 1.9 7.9 9.4 5.2 6.5 9.4 1.7 1 0 0 1 1 1 0 Allexivirus 40kDa protein zf-C3HC4_3 PF13920.6 ELR21171.1 - 2.1 8.3 14.3 2.1 8.3 6.2 3.1 3 0 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 ELR21171.1 - 2.6 8.4 18.0 0.11 12.8 8.4 3.2 3 0 0 3 3 3 0 RING-H2 zinc finger domain Topoisom_I_N PF02919.15 ELR21171.1 - 3.2 7.2 12.8 7.3 6.0 12.8 1.5 1 0 0 1 1 1 0 Eukaryotic DNA topoisomerase I, DNA binding fragment Elf1 PF05129.13 ELR21171.1 - 3.5 7.8 5.7 0.62 10.2 0.1 2.8 3 0 0 3 3 2 0 Transcription elongation factor Elf1 like Noggin PF05806.12 ELR21171.1 - 4.2 7.2 13.2 2.7 7.9 10.5 2.0 2 0 0 2 2 2 0 Noggin Zn_Tnp_IS1595 PF12760.7 ELR21171.1 - 4.8 7.2 10.2 1.7 8.7 1.3 3.4 3 0 0 3 3 3 0 Transposase zinc-ribbon domain VIT1 PF01988.19 ELR21171.1 - 5.2 6.9 7.4 14 5.5 7.4 1.8 1 0 0 1 1 1 0 VIT family RhoGEF PF00621.20 ELR21172.1 - 1e-42 146.4 2.7 1.4e-42 146.0 2.7 1.2 1 0 0 1 1 1 1 RhoGEF domain PH PF00169.29 ELR21172.1 - 1.2e-09 38.6 0.0 2.2e-09 37.7 0.0 1.5 1 0 0 1 1 1 1 PH domain PH_13 PF16652.5 ELR21172.1 - 0.0012 18.7 0.2 0.0025 17.6 0.2 1.5 1 0 0 1 1 1 1 Pleckstrin homology domain PH_5 PF15405.6 ELR21172.1 - 0.0048 17.0 0.1 0.68 10.0 0.0 2.5 2 0 0 2 2 2 1 Pleckstrin homology domain PH_16 PF17838.1 ELR21172.1 - 0.015 15.1 0.0 1.5 8.6 0.0 2.4 2 0 0 2 2 2 0 PH domain IQ_SEC7_PH PF16453.5 ELR21172.1 - 0.09 12.7 0.8 0.29 11.1 0.8 1.8 1 1 0 1 1 1 0 PH domain Pkinase_Tyr PF07714.17 ELR21173.1 - 7.5e-33 113.9 0.0 1.1e-32 113.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ELR21173.1 - 1e-32 113.6 0.0 1.5e-16 60.6 0.0 2.0 2 0 0 2 2 2 2 Protein kinase domain APH PF01636.23 ELR21173.1 - 3.1e-05 24.0 0.0 0.0001 22.4 0.0 1.7 2 0 0 2 2 2 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 ELR21173.1 - 0.0092 15.0 0.0 0.019 13.9 0.0 1.4 2 0 0 2 2 2 1 Haspin like kinase domain Seadorna_VP7 PF07387.11 ELR21173.1 - 0.03 13.4 0.0 0.047 12.7 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 RhoGEF PF00621.20 ELR21174.1 - 2.9e-26 92.8 0.2 4.6e-26 92.2 0.2 1.3 1 0 0 1 1 1 1 RhoGEF domain PH PF00169.29 ELR21174.1 - 7.6e-10 39.3 0.1 1.4e-09 38.4 0.1 1.4 1 0 0 1 1 1 1 PH domain PH_5 PF15405.6 ELR21174.1 - 0.002 18.2 0.1 0.4 10.8 0.0 2.3 2 0 0 2 2 2 2 Pleckstrin homology domain PH_13 PF16652.5 ELR21174.1 - 0.0026 17.6 1.1 0.0061 16.4 1.1 1.6 1 1 0 1 1 1 1 Pleckstrin homology domain PH_16 PF17838.1 ELR21174.1 - 0.006 16.4 0.0 0.82 9.5 0.0 2.3 2 0 0 2 2 2 2 PH domain IQ_SEC7_PH PF16453.5 ELR21174.1 - 0.069 13.1 1.3 0.23 11.4 1.3 1.9 1 1 0 1 1 1 0 PH domain His_Phos_1 PF00300.22 ELR21175.1 - 1.3e-05 25.0 3.2 1.3e-05 24.9 0.0 2.3 3 0 0 3 3 3 1 Histidine phosphatase superfamily (branch 1) Actin PF00022.19 ELR21176.1 - 1.2e-62 211.9 0.0 2e-62 211.1 0.0 1.3 1 0 0 1 1 1 1 Actin FERM_f0 PF16511.5 ELR21176.1 - 0.00021 21.5 0.1 0.11 12.8 0.1 2.4 2 0 0 2 2 2 2 N-terminal or F0 domain of Talin-head FERM PBP1_TM PF14812.6 ELR21176.1 - 4.4 7.7 11.1 9.9 6.6 5.1 3.0 3 0 0 3 3 3 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Na_H_Exchanger PF00999.21 ELR21177.1 - 1.7e-26 92.9 17.8 2e-26 92.7 17.8 1.0 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family Lys_export PF03956.13 ELR21177.1 - 0.0011 18.6 1.4 0.0011 18.6 1.4 2.0 2 1 0 2 2 2 1 Lysine exporter LysO His_Phos_1 PF00300.22 ELR21178.1 - 5.6e-12 45.8 1.5 3.1e-09 36.8 0.0 2.8 2 1 1 3 3 3 2 Histidine phosphatase superfamily (branch 1) DUF4364 PF14277.6 ELR21178.1 - 0.037 13.8 0.0 0.086 12.6 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4364) L_lactis_ph-MCP PF06673.11 ELR21178.1 - 0.053 12.5 0.7 0.073 12.1 0.7 1.2 1 0 0 1 1 1 0 Lactococcus lactis bacteriophage major capsid protein DUF3585 PF12130.8 ELR21179.1 - 0.014 15.6 2.5 0.014 15.6 2.5 2.3 2 1 0 2 2 2 0 Bivalent Mical/EHBP Rab binding domain ThylakoidFormat PF11264.8 ELR21179.1 - 0.13 11.9 5.0 0.33 10.6 5.0 1.6 1 0 0 1 1 1 0 Thylakoid formation protein Lipase_3 PF01764.25 ELR21179.1 - 0.2 11.5 1.0 5.9 6.8 0.0 2.4 2 0 0 2 2 2 0 Lipase (class 3) DUF1834 PF08873.11 ELR21179.1 - 0.38 10.5 3.0 1.7 8.4 3.0 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF1834) DUF4140 PF13600.6 ELR21179.1 - 0.4 11.2 0.1 0.4 11.2 0.1 2.7 2 1 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) Na_H_Exchanger PF00999.21 ELR21180.1 - 1.4e-53 182.1 54.0 1.8e-53 181.7 54.0 1.1 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family Usp PF00582.26 ELR21180.1 - 0.01 16.3 1.2 7.5 7.1 0.0 3.3 3 0 0 3 3 3 0 Universal stress protein family HTH_Tnp_Tc3_2 PF01498.18 ELR21180.1 - 0.12 12.6 0.2 0.26 11.5 0.2 1.5 1 0 0 1 1 1 0 Transposase Na_H_Exchanger PF00999.21 ELR21181.1 - 1.2e-59 202.0 52.9 1.8e-59 201.5 52.9 1.1 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family Usp PF00582.26 ELR21181.1 - 4.8 7.7 11.7 9.5 6.7 0.1 4.2 5 0 0 5 5 5 0 Universal stress protein family Pkinase_Tyr PF07714.17 ELR21182.1 - 1.8e-49 168.3 0.1 1.4e-38 132.7 0.2 3.0 3 0 0 3 3 3 2 Protein tyrosine kinase Pkinase PF00069.25 ELR21182.1 - 4.3e-43 147.6 0.0 4e-35 121.4 0.0 2.8 3 0 0 3 3 3 2 Protein kinase domain SH2 PF00017.24 ELR21182.1 - 6.2e-05 23.0 0.2 0.00015 21.8 0.2 1.7 1 0 0 1 1 1 1 SH2 domain Haspin_kinase PF12330.8 ELR21182.1 - 0.0061 15.5 0.0 0.012 14.5 0.0 1.4 1 0 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 ELR21182.1 - 0.0079 15.6 0.0 0.015 14.6 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family AroM PF07302.11 ELR21182.1 - 0.022 14.2 0.0 0.045 13.1 0.0 1.5 1 0 0 1 1 1 0 AroM protein Cbl_N3 PF02762.14 ELR21182.1 - 0.072 13.0 0.0 0.23 11.3 0.0 1.9 1 1 0 1 1 1 0 CBL proto-oncogene N-terminus, SH2-like domain FTA2 PF13095.6 ELR21182.1 - 0.095 12.3 0.0 0.2 11.2 0.0 1.7 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 SH2_2 PF14633.6 ELR21182.1 - 0.11 11.9 0.0 0.18 11.2 0.0 1.3 1 0 0 1 1 1 0 SH2 domain PPTA PF01239.22 ELR21183.1 - 2.9e-18 65.0 9.7 1.4e-06 27.8 0.1 5.2 5 0 0 5 5 5 3 Protein prenyltransferase alpha subunit repeat Caldesmon PF02029.15 ELR21183.1 - 8e-05 21.6 20.2 0.00011 21.2 20.2 1.3 1 0 0 1 1 1 1 Caldesmon Raftlin PF15250.6 ELR21183.1 - 0.0059 15.4 12.1 0.0078 15.0 12.1 1.1 1 0 0 1 1 1 1 Raftlin DUF4045 PF13254.6 ELR21183.1 - 0.089 12.4 15.9 0.11 12.1 15.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) Ndc1_Nup PF09531.10 ELR21183.1 - 0.2 10.3 6.5 0.24 10.1 6.5 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Herpes_UL17 PF04559.12 ELR21183.1 - 0.6 8.8 6.1 0.83 8.4 6.1 1.2 1 0 0 1 1 1 0 Herpesvirus UL17 protein Zip PF02535.22 ELR21183.1 - 3 7.0 11.3 4.3 6.4 11.3 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter Presenilin PF01080.17 ELR21183.1 - 4.6 5.9 19.6 6.2 5.5 19.6 1.2 1 0 0 1 1 1 0 Presenilin SAPS PF04499.15 ELR21183.1 - 9.3 4.9 14.6 12 4.5 14.6 1.2 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein AKAP2_C PF15304.6 ELR21184.1 - 0.005 16.2 2.5 0.0064 15.8 2.5 1.1 1 0 0 1 1 1 1 A-kinase anchor protein 2 C-terminus SR-25 PF10500.9 ELR21184.1 - 0.022 14.4 9.8 0.029 14.0 9.8 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein TOM20_plant PF06552.12 ELR21184.1 - 0.098 12.4 0.6 0.23 11.2 0.1 1.7 2 0 0 2 2 2 0 Plant specific mitochondrial import receptor subunit TOM20 DnaJ PF00226.31 ELR21185.1 - 0.00048 20.2 0.0 0.00081 19.5 0.0 1.3 1 0 0 1 1 1 1 DnaJ domain CDC48_N PF02359.18 ELR21185.1 - 0.049 13.8 0.0 0.083 13.1 0.0 1.3 1 0 0 1 1 1 0 Cell division protein 48 (CDC48), N-terminal domain ComA PF02679.15 ELR21185.1 - 0.17 11.3 0.0 0.23 10.9 0.0 1.1 1 0 0 1 1 1 0 (2R)-phospho-3-sulfolactate synthase (ComA) CDKN3 PF05706.12 ELR21186.1 - 1.3e-09 38.0 0.0 1.5e-09 37.7 0.0 1.1 1 0 0 1 1 1 1 Cyclin-dependent kinase inhibitor 3 (CDKN3) DSPc PF00782.20 ELR21186.1 - 2.1e-08 34.1 0.0 2.8e-08 33.7 0.0 1.2 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 ELR21186.1 - 2.9e-07 30.7 0.1 3e-07 30.6 0.1 1.2 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase PF00102.27 ELR21186.1 - 0.00062 19.4 0.0 0.00074 19.1 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase2 PF03162.13 ELR21186.1 - 0.0053 16.4 0.1 0.0083 15.7 0.1 1.2 1 0 0 1 1 1 1 Tyrosine phosphatase family NeuB PF03102.14 ELR21186.1 - 0.074 12.5 0.0 0.1 12.1 0.0 1.2 1 0 0 1 1 1 0 NeuB family Peptidase_C92 PF05708.12 ELR21188.1 - 5.9e-13 49.3 0.0 1.7e-12 47.7 0.0 1.7 1 1 0 1 1 1 1 Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family C2 PF00168.30 ELR21188.1 - 5.4e-08 33.1 0.0 1e-07 32.1 0.0 1.4 1 0 0 1 1 1 1 C2 domain BUD22 PF09073.10 ELR21188.1 - 0.76 9.1 59.9 1.5 8.1 24.7 2.4 2 0 0 2 2 2 0 BUD22 SIN1_PH PF16979.5 ELR21189.1 - 1.3e-13 51.2 0.8 2.4e-13 50.3 0.8 1.4 1 0 0 1 1 1 1 SAPK-interacting protein 1 (Sin1), Pleckstrin-homology CRIM PF16978.5 ELR21189.1 - 3.4e-06 27.3 0.1 9.8e-05 22.5 0.0 3.1 2 1 1 3 3 3 1 SAPK-interacting protein 1 (Sin1), middle CRIM domain UPF0020 PF01170.18 ELR21190.1 - 2.5e-27 95.8 0.0 1.2e-26 93.6 0.0 1.9 1 1 0 1 1 1 1 Putative RNA methylase family UPF0020 THUMP PF02926.17 ELR21190.1 - 2.7e-05 24.3 0.0 4.6e-05 23.5 0.0 1.4 1 0 0 1 1 1 1 THUMP domain Methyltransf_11 PF08241.12 ELR21190.1 - 0.00021 21.9 0.0 0.00052 20.6 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ELR21190.1 - 0.00022 21.8 0.0 0.00053 20.6 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_15 PF09445.10 ELR21190.1 - 0.00056 19.5 0.0 0.00081 19.0 0.0 1.3 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase N6_N4_Mtase PF01555.18 ELR21190.1 - 0.0015 18.3 0.0 0.0029 17.3 0.0 1.5 2 0 0 2 2 2 1 DNA methylase Methyltransf_31 PF13847.6 ELR21190.1 - 0.0019 18.0 0.0 0.0039 17.0 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain AviRa PF11599.8 ELR21190.1 - 0.029 13.8 0.0 0.1 12.0 0.0 1.8 1 1 1 2 2 2 0 RRNA methyltransferase AviRa Met_10 PF02475.16 ELR21190.1 - 0.029 14.1 0.0 0.047 13.4 0.0 1.3 1 0 0 1 1 1 0 Met-10+ like-protein MTS PF05175.14 ELR21190.1 - 0.054 13.1 0.0 0.094 12.3 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain SnoaL_3 PF13474.6 ELR21190.1 - 0.068 13.4 0.1 0.86 9.9 0.0 2.3 2 0 0 2 2 2 0 SnoaL-like domain bZIP_1 PF00170.21 ELR21191.1 - 0.0015 18.6 2.7 0.0015 18.6 2.7 3.9 2 1 2 4 4 4 1 bZIP transcription factor Fmp27_WPPW PF10359.9 ELR21191.1 - 0.0022 16.9 3.8 0.0029 16.5 3.8 1.1 1 0 0 1 1 1 1 RNA pol II promoter Fmp27 protein domain DUF4686 PF15742.5 ELR21191.1 - 0.0028 16.9 11.5 0.0033 16.6 11.5 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4686) Macoilin PF09726.9 ELR21191.1 - 0.0037 15.9 2.5 0.0039 15.8 2.5 1.1 1 0 0 1 1 1 1 Macoilin family PI3K_P85_iSH2 PF16454.5 ELR21191.1 - 0.0066 16.1 4.6 0.0066 16.1 4.6 2.1 1 1 1 2 2 2 1 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain DUF3450 PF11932.8 ELR21191.1 - 0.0066 15.8 5.9 0.01 15.1 5.7 1.5 1 1 1 2 2 2 1 Protein of unknown function (DUF3450) Myosin_tail_1 PF01576.19 ELR21191.1 - 0.0076 14.1 16.3 0.031 12.1 16.5 1.6 1 1 1 2 2 2 1 Myosin tail Leu_zip PF15294.6 ELR21191.1 - 0.016 14.7 10.2 0.022 14.3 10.2 1.3 1 0 0 1 1 1 0 Leucine zipper bZIP_2 PF07716.15 ELR21191.1 - 0.027 14.5 2.3 0.027 14.5 2.3 3.7 3 1 1 4 4 4 0 Basic region leucine zipper DMPK_coil PF08826.10 ELR21191.1 - 0.03 14.4 6.5 0.03 14.4 6.5 2.0 2 0 0 2 2 2 0 DMPK coiled coil domain like Prominin PF05478.11 ELR21191.1 - 0.031 12.3 0.7 0.041 11.9 0.7 1.1 1 0 0 1 1 1 0 Prominin Ax_dynein_light PF10211.9 ELR21191.1 - 0.044 13.7 14.1 3 7.8 14.1 2.2 1 1 0 1 1 1 0 Axonemal dynein light chain Miff PF05644.11 ELR21191.1 - 0.047 13.3 1.4 0.065 12.9 1.4 1.2 1 0 0 1 1 1 0 Mitochondrial and peroxisomal fission factor Mff Nup54 PF13874.6 ELR21191.1 - 0.049 13.7 10.3 0.12 12.4 10.3 1.6 1 1 0 1 1 1 0 Nucleoporin complex subunit 54 DivIC PF04977.15 ELR21191.1 - 0.051 13.3 0.7 0.051 13.3 0.7 2.9 2 1 1 3 3 3 0 Septum formation initiator Fez1 PF06818.15 ELR21191.1 - 0.06 13.8 11.1 0.082 13.4 11.1 1.1 1 0 0 1 1 1 0 Fez1 DUF2802 PF10975.8 ELR21191.1 - 0.088 13.0 7.4 0.11 12.6 1.4 3.3 2 1 1 3 3 3 0 Protein of unknown function (DUF2802) APG6_N PF17675.1 ELR21191.1 - 0.16 12.5 12.8 0.35 11.4 12.8 1.6 1 1 0 1 1 1 0 Apg6 coiled-coil region ATG16 PF08614.11 ELR21191.1 - 0.2 11.8 13.7 0.036 14.3 9.1 1.8 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) DUF1664 PF07889.12 ELR21191.1 - 0.21 11.6 3.9 0.18 11.9 1.7 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) GAS PF13851.6 ELR21191.1 - 0.23 10.8 13.2 0.43 9.9 13.3 1.4 1 1 0 1 1 1 0 Growth-arrest specific micro-tubule binding CENP-H PF05837.12 ELR21191.1 - 0.26 11.7 12.4 0.14 12.6 8.4 2.0 1 1 1 2 2 2 0 Centromere protein H (CENP-H) Csm1_N PF18504.1 ELR21191.1 - 0.29 11.5 13.1 0.16 12.3 4.3 2.9 2 1 1 3 3 3 0 Csm1 N-terminal domain GIT_CC PF16559.5 ELR21191.1 - 0.33 10.8 8.6 1.1 9.2 5.5 2.6 1 1 1 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor TolA_bind_tri PF16331.5 ELR21191.1 - 0.39 10.8 8.5 1.2 9.3 8.3 1.9 1 1 0 1 1 1 0 TolA binding protein trimerisation FlaC_arch PF05377.11 ELR21191.1 - 0.56 10.7 7.8 0.85 10.1 1.4 3.1 2 1 1 3 3 3 0 Flagella accessory protein C (FlaC) V_ATPase_I PF01496.19 ELR21191.1 - 0.76 7.6 3.5 0.91 7.4 3.5 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Lebercilin PF15619.6 ELR21191.1 - 0.95 9.1 16.2 20 4.8 14.6 2.8 1 1 1 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease HAUS-augmin3 PF14932.6 ELR21191.1 - 1.2 8.7 9.6 1.6 8.2 9.6 1.3 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 3 TMCO5 PF14992.6 ELR21191.1 - 1.2 8.7 10.7 1.5 8.4 10.7 1.1 1 0 0 1 1 1 0 TMCO5 family CENP-F_leu_zip PF10473.9 ELR21191.1 - 1.4 8.9 16.4 2.7 8.0 16.4 1.5 1 1 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 BRE1 PF08647.11 ELR21191.1 - 1.4 9.0 14.7 0.8 9.8 9.2 2.7 1 1 1 2 2 2 0 BRE1 E3 ubiquitin ligase BST2 PF16716.5 ELR21191.1 - 1.6 9.4 13.7 0.41 11.3 5.8 2.7 1 1 2 3 3 3 0 Bone marrow stromal antigen 2 DUF724 PF05266.14 ELR21191.1 - 1.8 8.3 10.8 4.6 7.0 10.7 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF724) ADIP PF11559.8 ELR21191.1 - 2.1 8.4 14.2 18 5.4 14.2 2.2 1 1 0 1 1 1 0 Afadin- and alpha -actinin-Binding DUF4407 PF14362.6 ELR21191.1 - 2.5 7.4 10.6 3 7.1 10.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) YabA PF06156.13 ELR21191.1 - 2.6 8.7 11.3 25 5.6 10.8 2.4 1 1 1 2 2 2 0 Initiation control protein YabA SHE3 PF17078.5 ELR21191.1 - 2.8 7.6 12.8 74 2.9 12.7 2.0 1 1 0 1 1 1 0 SWI5-dependent HO expression protein 3 DUF4140 PF13600.6 ELR21191.1 - 3.5 8.1 7.4 1.5 9.3 0.6 2.7 1 1 2 3 3 3 0 N-terminal domain of unknown function (DUF4140) TMPIT PF07851.13 ELR21191.1 - 3.8 6.7 5.4 7.4 5.7 5.5 1.4 1 1 0 1 1 1 0 TMPIT-like protein UPF0242 PF06785.11 ELR21191.1 - 5.7 7.0 12.2 41 4.2 12.2 2.0 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus TSC22 PF01166.18 ELR21191.1 - 6.1 7.2 9.9 12 6.3 0.7 3.3 2 1 1 3 3 2 0 TSC-22/dip/bun family Occludin_ELL PF07303.13 ELR21191.1 - 6.1 7.6 6.8 5.2 7.9 2.6 2.2 1 1 0 2 2 2 0 Occludin homology domain CCDC-167 PF15188.6 ELR21191.1 - 7.1 7.1 15.1 0.79 10.1 6.0 2.3 1 1 1 2 2 2 0 Coiled-coil domain-containing protein 167 Shugoshin_N PF07558.11 ELR21191.1 - 7.3 6.6 13.3 3.5 7.6 0.8 3.4 2 1 2 4 4 3 0 Shugoshin N-terminal coiled-coil region ABC_tran_CTD PF16326.5 ELR21191.1 - 9.8 6.5 11.1 2.2 8.6 4.0 2.7 1 1 1 2 2 2 0 ABC transporter C-terminal domain RVT_1 PF00078.27 ELR21192.1 - 1.2e-08 34.8 0.9 2.3e-08 33.8 0.3 1.8 3 0 0 3 3 3 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH PF17917.1 ELR21192.1 - 5.2e-05 23.5 0.0 9.7e-05 22.6 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 ELR21192.1 - 0.066 13.3 0.0 0.19 11.7 0.0 1.8 1 0 0 1 1 1 0 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 ELR21193.1 - 0.00049 19.7 0.0 0.00073 19.1 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) REJ PF02010.15 ELR21195.1 - 7.9e-47 160.1 0.4 7e-46 156.9 0.3 2.1 1 1 1 2 2 2 1 REJ domain GPS PF01825.21 ELR21195.1 - 4.3e-07 30.3 0.5 1.1e-06 29.1 0.5 1.7 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif PKD PF00801.20 ELR21195.1 - 0.059 13.2 7.3 2.7 7.9 0.1 3.8 3 1 0 3 3 3 0 PKD domain EphA2_TM PF14575.6 ELR21195.1 - 0.059 14.2 0.4 0.14 13.0 0.4 1.6 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain RIFIN PF02009.16 ELR21195.1 - 0.096 12.6 0.6 0.17 11.7 0.6 1.3 1 0 0 1 1 1 0 Rifin LRR_9 PF14580.6 ELR21195.1 - 0.11 11.9 0.1 0.6 9.6 0.0 2.0 1 1 1 2 2 2 0 Leucine-rich repeat LRR_4 PF12799.7 ELR21195.1 - 0.58 10.7 10.5 3.1 8.4 0.1 4.4 5 1 0 5 5 5 0 Leucine Rich repeats (2 copies) Sec16_C PF12931.7 ELR21196.1 - 1.3e-50 172.8 0.0 5.8e-50 170.7 0.0 1.8 1 1 0 1 1 1 1 Sec23-binding domain of Sec16 Sec16 PF12932.7 ELR21196.1 - 1.1e-16 61.5 0.0 2.6e-16 60.3 0.0 1.7 1 0 0 1 1 1 1 Vesicle coat trafficking protein Sec16 mid-region Ras PF00071.22 ELR21197.1 - 1.1e-35 122.6 0.0 7.9e-32 110.1 0.0 2.2 2 0 0 2 2 2 2 Ras family Roc PF08477.13 ELR21197.1 - 1.1e-10 41.7 0.0 2.4e-10 40.7 0.0 1.6 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase PH PF00169.29 ELR21197.1 - 1.7e-06 28.4 0.0 4.1e-06 27.2 0.0 1.7 1 0 0 1 1 1 1 PH domain MMR_HSR1 PF01926.23 ELR21197.1 - 0.14 12.3 0.0 0.26 11.4 0.0 1.5 1 0 0 1 1 1 0 50S ribosome-binding GTPase LRR_6 PF13516.6 ELR21198.1 - 4.4e-20 70.0 0.1 0.0086 16.1 0.0 8.0 8 0 0 8 8 8 5 Leucine Rich repeat LRR_4 PF12799.7 ELR21198.1 - 1.7e-14 53.7 1.3 0.08 13.4 0.0 5.7 2 1 5 7 7 7 6 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 ELR21198.1 - 1.5e-08 34.2 2.4 0.023 14.4 0.1 5.8 2 2 3 5 5 5 4 Leucine rich repeat LRR_1 PF00560.33 ELR21198.1 - 2.3e-07 30.4 11.3 6.6 7.7 1.1 8.0 7 2 0 7 7 7 3 Leucine Rich Repeat Herpes_gI PF01688.17 ELR21198.1 - 0.0027 17.6 0.7 0.88 9.5 0.0 2.4 2 0 0 2 2 2 2 Alphaherpesvirus glycoprotein I DUF1699 PF08004.11 ELR21198.1 - 0.13 11.9 0.1 32 4.2 0.0 3.5 2 2 3 5 5 5 0 Protein of unknown function (DUF1699) Fascin PF06268.13 ELR21199.1 - 1.6e-20 73.4 0.1 1.2e-11 44.8 0.0 2.1 1 1 1 2 2 2 2 Fascin domain FRG1 PF06229.12 ELR21199.1 - 4.3e-18 65.7 0.3 5.3e-08 32.8 0.1 2.9 1 1 2 3 3 3 3 FRG1-like domain RicinB_lectin_2 PF14200.6 ELR21199.1 - 3.5e-07 30.9 0.1 0.0013 19.4 0.0 2.1 1 1 1 2 2 2 2 Ricin-type beta-trefoil lectin domain-like FGF PF00167.18 ELR21199.1 - 1.6e-06 28.2 0.0 1.2e-05 25.4 0.0 1.9 2 0 0 2 2 2 1 Fibroblast growth factor DUF569 PF04601.13 ELR21199.1 - 5.6e-06 26.1 0.1 0.00016 21.4 0.1 2.1 1 1 1 2 2 2 1 Domain of unknown function (DUF569) IL8 PF00048.20 ELR21199.1 - 0.022 14.9 0.0 0.92 9.7 0.0 2.2 2 0 0 2 2 2 0 Small cytokines (intecrine/chemokine), interleukin-8 like PLDc PF00614.22 ELR21199.1 - 0.068 13.4 3.4 0.15 12.3 0.1 2.4 2 0 0 2 2 2 0 Phospholipase D Active site motif Inhibitor_I67 PF11405.8 ELR21199.1 - 0.097 12.9 0.2 14 6.0 0.0 2.7 3 0 0 3 3 3 0 Bromelain inhibitor VI Ras PF00071.22 ELR21200.1 - 4.1e-47 159.8 0.0 5.4e-47 159.4 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR21200.1 - 6.7e-18 65.1 0.0 1.3e-17 64.1 0.0 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR21200.1 - 0.002 17.6 0.0 0.005 16.3 0.0 1.7 1 1 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 ELR21200.1 - 0.014 14.9 0.0 0.04 13.5 0.0 1.8 1 1 1 2 2 2 0 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 ELR21200.1 - 0.049 13.7 0.0 0.09 12.9 0.0 1.5 1 0 0 1 1 1 0 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 ELR21200.1 - 0.084 12.8 0.0 3.7 7.4 0.0 2.2 2 0 0 2 2 2 0 RsgA GTPase Ank_2 PF12796.7 ELR21202.1 - 3.2e-14 53.3 0.0 1.5e-06 28.6 0.0 3.9 2 1 2 4 4 4 3 Ankyrin repeats (3 copies) F-box-like PF12937.7 ELR21202.1 - 2.2e-06 27.4 2.0 3.4e-06 26.8 0.3 2.3 2 0 0 2 2 2 1 F-box-like Ank_3 PF13606.6 ELR21202.1 - 4.6e-06 26.6 0.1 29 5.7 0.0 6.0 6 0 0 6 6 6 1 Ankyrin repeat Ank_4 PF13637.6 ELR21202.1 - 9.7e-05 22.8 0.0 0.8 10.4 0.0 3.9 2 1 2 4 4 4 3 Ankyrin repeats (many copies) Ank PF00023.30 ELR21202.1 - 0.00099 19.5 0.0 79 4.0 0.0 5.1 5 0 0 5 5 5 0 Ankyrin repeat F-box PF00646.33 ELR21202.1 - 0.2 11.6 3.8 0.61 10.0 0.7 2.4 2 0 0 2 2 2 0 F-box domain RCC1 PF00415.18 ELR21203.1 - 1.3e-78 259.5 15.0 2.9e-13 50.2 0.0 7.2 7 0 0 7 7 7 7 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 ELR21203.1 - 3.2e-36 122.4 32.8 1e-09 37.9 2.3 7.3 8 0 0 8 8 8 5 Regulator of chromosome condensation (RCC1) repeat RHS_repeat PF05593.14 ELR21203.1 - 0.77 10.3 2.9 60 4.3 0.2 3.4 3 0 0 3 3 3 0 RHS Repeat zf-C2H2_jaz PF12171.8 ELR21204.1 - 1.4e-10 41.2 4.1 3.1e-10 40.1 4.1 1.6 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.7 ELR21204.1 - 0.0083 16.4 2.4 0.0085 16.4 1.6 1.5 1 1 0 1 1 1 1 C2H2 type zinc-finger (2 copies) zf-met PF12874.7 ELR21204.1 - 0.019 15.4 1.2 0.019 15.4 1.2 2.0 3 0 0 3 3 3 0 Zinc-finger of C2H2 type zf-C2H2_4 PF13894.6 ELR21204.1 - 0.039 14.8 0.5 0.039 14.8 0.5 1.9 2 0 0 2 2 2 0 C2H2-type zinc finger DUF2674 PF10879.8 ELR21204.1 - 0.061 12.9 0.0 0.13 11.8 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2674) ADH_zinc_N_2 PF13602.6 ELR21204.1 - 0.076 14.1 0.0 4.1 8.5 0.0 2.1 1 1 1 2 2 2 0 Zinc-binding dehydrogenase DUF4269 PF14091.6 ELR21204.1 - 0.076 13.3 0.0 0.1 12.9 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4269) zf-MYST PF17772.1 ELR21204.1 - 0.079 12.6 0.3 0.15 11.6 0.3 1.4 1 0 0 1 1 1 0 MYST family zinc finger domain WD40 PF00400.32 ELR21205.1 - 2.2e-64 211.9 22.1 1.1e-10 41.9 0.1 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ELR21205.1 - 4.8e-28 97.3 1.1 1e-05 25.7 0.0 6.1 1 1 5 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 ELR21205.1 - 1.1e-14 54.7 0.6 1.3e-07 31.7 0.0 3.8 1 1 3 4 4 4 3 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 ELR21205.1 - 1.7e-13 50.1 6.7 0.038 12.6 0.0 5.9 1 1 5 6 6 6 5 Nucleoporin Nup120/160 WD40_like PF17005.5 ELR21205.1 - 1.4e-09 37.7 0.0 5.7e-05 22.6 0.0 3.2 1 1 3 4 4 4 3 WD40-like domain Ge1_WD40 PF16529.5 ELR21205.1 - 6.7e-06 25.3 5.3 0.42 9.5 0.0 4.1 1 1 0 3 3 3 3 WD40 region of Ge1, enhancer of mRNA-decapping protein PALB2_WD40 PF16756.5 ELR21205.1 - 2.6e-05 23.3 6.4 0.38 9.6 0.1 5.2 1 1 5 6 6 6 2 Partner and localizer of BRCA2 WD40 domain Frtz PF11768.8 ELR21205.1 - 5.2e-05 21.8 0.0 0.0022 16.4 0.0 2.7 1 1 1 3 3 3 1 WD repeat-containing and planar cell polarity effector protein Fritz CDtoxinA PF03498.14 ELR21205.1 - 0.00071 19.2 0.2 0.39 10.3 0.0 2.8 1 1 2 3 3 3 2 Cytolethal distending toxin A/C domain VID27 PF08553.10 ELR21205.1 - 0.0019 17.3 0.1 3.2 6.7 0.0 3.3 1 1 3 4 4 4 2 VID27 C-terminal WD40-like domain Cytochrom_D1 PF02239.16 ELR21205.1 - 0.0029 16.2 0.0 0.69 8.4 0.0 2.8 1 1 1 3 3 3 2 Cytochrome D1 heme domain G-patch PF01585.23 ELR21206.1 - 3.1e-10 39.8 3.0 9.2e-10 38.3 3.0 1.9 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.7 ELR21206.1 - 0.00081 19.4 1.4 0.0034 17.5 1.4 2.1 1 0 0 1 1 1 1 G-patch domain DUF4559 PF15112.6 ELR21206.1 - 0.044 13.5 5.1 0.069 12.8 5.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4559) Pol_alpha_B_N PF08418.10 ELR21206.1 - 0.071 13.1 6.9 3.9 7.4 0.0 2.3 2 0 0 2 2 2 0 DNA polymerase alpha subunit B N-terminal DUF1515 PF07439.11 ELR21206.1 - 0.35 10.9 2.5 0.87 9.6 2.5 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1515) DUF2203 PF09969.9 ELR21206.1 - 0.73 10.6 7.1 0.74 10.6 4.4 2.3 3 0 0 3 3 3 0 Uncharacterized conserved protein (DUF2203) DHR10 PF18595.1 ELR21206.1 - 1.1 9.3 15.7 3.1 7.9 15.7 1.8 1 0 0 1 1 1 0 Designed helical repeat protein 10 domain DUF1690 PF07956.11 ELR21206.1 - 4.1 7.8 9.9 12 6.3 9.9 1.8 1 0 0 1 1 1 0 Protein of Unknown function (DUF1690) I-set PF07679.16 ELR21207.1 - 0.00046 20.2 0.0 0.00089 19.3 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin I-set domain DnaJ PF00226.31 ELR21207.1 - 0.0018 18.3 0.0 0.0047 17.0 0.0 1.7 1 0 0 1 1 1 1 DnaJ domain Ig_3 PF13927.6 ELR21207.1 - 0.0027 18.3 0.0 0.0069 17.0 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin domain DDE_3 PF13358.6 ELR21208.1 - 2e-14 53.6 0.0 3.3e-14 52.9 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_33 PF13592.6 ELR21208.1 - 0.031 13.9 0.7 0.61 9.8 0.1 2.4 2 0 0 2 2 2 0 Winged helix-turn helix Med8 PF10232.9 ELR21209.1 - 0.014 15.0 0.3 0.027 14.1 0.2 1.5 1 1 0 1 1 1 0 Mediator of RNA polymerase II transcription complex subunit 8 DUF4570 PF15134.6 ELR21209.1 - 1.2 9.2 8.5 3.9 7.5 2.6 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4570) Globin PF00042.22 ELR21210.1 - 0.012 16.2 0.0 0.014 15.9 0.0 1.0 1 0 0 1 1 1 0 Globin Dehydrin PF00257.19 ELR21210.1 - 0.052 14.1 0.8 0.06 13.9 0.8 1.1 1 0 0 1 1 1 0 Dehydrin NLRC4_HD2 PF17776.1 ELR21210.1 - 0.06 13.9 0.1 0.06 13.9 0.1 1.1 1 0 0 1 1 1 0 NLRC4 helical domain HD2 CLU PF13236.6 ELR21212.1 - 2.3e-55 187.8 0.0 4e-55 187.1 0.0 1.3 1 0 0 1 1 1 1 Clustered mitochondria eIF3_p135 PF12807.7 ELR21212.1 - 8.2e-13 48.8 0.0 8.2e-13 48.8 0.0 2.0 2 0 0 2 2 2 1 Translation initiation factor eIF3 subunit 135 YABBY PF04690.13 ELR21212.1 - 7.3 7.1 10.1 1 9.9 3.6 2.7 2 0 0 2 2 2 0 YABBY protein Ras PF00071.22 ELR21213.1 - 4.2e-11 42.7 0.0 1.1e-10 41.4 0.0 1.7 1 1 0 1 1 1 1 Ras family F-box-like PF12937.7 ELR21213.1 - 7.3e-08 32.2 0.1 1.7e-07 31.0 0.1 1.6 1 0 0 1 1 1 1 F-box-like Roc PF08477.13 ELR21213.1 - 2.2e-06 27.9 0.0 0.0018 18.5 0.0 2.4 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase F-box PF00646.33 ELR21213.1 - 0.002 17.9 0.1 0.0041 17.0 0.1 1.5 1 0 0 1 1 1 1 F-box domain F-box_4 PF15966.5 ELR21213.1 - 0.011 15.6 0.0 0.02 14.7 0.0 1.4 1 0 0 1 1 1 0 F-box RhoGAP PF00620.27 ELR21214.1 - 7.5e-26 90.8 0.1 3.7e-25 88.5 0.1 2.0 1 1 0 1 1 1 1 RhoGAP domain RE_SinI PF09570.10 ELR21214.1 - 0.0044 16.3 0.0 0.0081 15.4 0.0 1.4 1 0 0 1 1 1 1 SinI restriction endonuclease HECT_2 PF09814.9 ELR21214.1 - 0.044 12.7 0.6 0.066 12.1 0.6 1.2 1 0 0 1 1 1 0 HECT-like Ubiquitin-conjugating enzyme (E2)-binding Peptidase_S9 PF00326.21 ELR21215.1 - 2.3e-59 200.4 0.3 3.1e-59 200.0 0.3 1.2 1 0 0 1 1 1 1 Prolyl oligopeptidase family PD40 PF07676.12 ELR21215.1 - 1.2e-14 53.8 0.7 0.00035 20.4 0.0 5.2 5 0 0 5 5 5 3 WD40-like Beta Propeller Repeat DPPIV_N PF00930.21 ELR21215.1 - 0.001 17.9 0.5 9.5 4.9 0.0 4.2 3 1 1 4 4 4 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region Peptidase_S15 PF02129.18 ELR21215.1 - 0.0018 17.9 1.2 0.94 9.0 1.8 2.4 1 1 1 2 2 2 2 X-Pro dipeptidyl-peptidase (S15 family) AXE1 PF05448.12 ELR21215.1 - 0.037 12.7 0.2 2.4 6.7 0.3 2.1 1 1 0 1 1 1 0 Acetyl xylan esterase (AXE1) Acetyltransf_3 PF13302.7 ELR21216.1 - 4.3e-19 69.6 0.0 5.6e-19 69.2 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 ELR21216.1 - 6.6e-08 32.8 0.0 1e-07 32.2 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_4 PF13420.7 ELR21216.1 - 0.069 13.3 0.0 0.089 12.9 0.0 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain SDA1 PF05285.12 ELR21217.1 - 7.8 5.8 35.8 9.2 5.6 35.8 1.2 1 0 0 1 1 1 0 SDA1 VWA PF00092.28 ELR21218.1 - 0.00045 20.5 0.0 0.0011 19.2 0.0 1.7 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.6 ELR21218.1 - 0.0016 19.0 0.1 0.0047 17.5 0.1 1.9 1 0 0 1 1 1 1 von Willebrand factor type A domain RR_TM4-6 PF06459.12 ELR21218.1 - 0.0045 16.8 5.9 0.0045 16.8 5.9 8.5 3 1 5 8 8 8 2 Ryanodine Receptor TM 4-6 DinB_2 PF12867.7 ELR21218.1 - 0.62 10.6 5.3 0.12 12.8 0.3 2.5 2 0 0 2 2 2 0 DinB superfamily ORC4_C PF14629.6 ELR21220.1 - 4.4e-10 39.3 0.1 7.9e-10 38.5 0.1 1.4 1 0 0 1 1 1 1 Origin recognition complex (ORC) subunit 4 C-terminus AAA_16 PF13191.6 ELR21220.1 - 2.1e-05 25.0 5.3 3.3e-05 24.3 3.8 2.0 1 1 1 2 2 2 1 AAA ATPase domain MMR_HSR1 PF01926.23 ELR21220.1 - 0.0056 16.7 0.0 0.011 15.8 0.0 1.6 1 1 0 1 1 1 1 50S ribosome-binding GTPase DUF4604 PF15377.6 ELR21220.1 - 0.0084 16.6 3.6 0.014 15.8 3.6 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4604) DDHD PF02862.17 ELR21220.1 - 0.014 15.5 0.5 0.015 15.5 0.5 1.2 1 0 0 1 1 1 0 DDHD domain DUF4834 PF16118.5 ELR21220.1 - 0.016 16.2 1.2 0.03 15.3 1.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) ALMT PF11744.8 ELR21220.1 - 0.016 14.0 0.7 0.022 13.6 0.7 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter TERB2 PF15101.6 ELR21220.1 - 0.019 15.0 4.4 0.03 14.4 4.4 1.3 1 0 0 1 1 1 0 Telomere-associated protein TERB2 Presenilin PF01080.17 ELR21220.1 - 0.025 13.4 0.3 0.027 13.2 0.3 1.1 1 0 0 1 1 1 0 Presenilin Spt20 PF12090.8 ELR21220.1 - 0.027 14.1 9.3 0.042 13.5 9.3 1.2 1 0 0 1 1 1 0 Spt20 family AAA_7 PF12775.7 ELR21220.1 - 0.035 13.6 0.0 0.074 12.6 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region CPSF100_C PF13299.6 ELR21220.1 - 0.045 13.9 2.7 0.067 13.4 2.7 1.2 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal FAM91_C PF14648.6 ELR21220.1 - 0.053 12.4 0.2 0.069 12.0 0.2 1.1 1 0 0 1 1 1 0 FAM91 C-terminus DUF4407 PF14362.6 ELR21220.1 - 0.06 12.7 6.7 0.065 12.6 4.6 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) AAA_22 PF13401.6 ELR21220.1 - 0.075 13.3 0.5 0.2 11.9 0.3 1.7 2 1 0 2 2 2 0 AAA domain Hid1 PF12722.7 ELR21220.1 - 0.088 10.9 2.8 0.1 10.7 2.8 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein MMR1 PF08505.10 ELR21220.1 - 0.11 12.7 4.2 0.17 12.2 4.2 1.2 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein TMEM51 PF15345.6 ELR21220.1 - 0.12 12.2 2.4 0.16 11.7 2.4 1.2 1 0 0 1 1 1 0 Transmembrane protein 51 UPF0560 PF10577.9 ELR21220.1 - 0.15 10.5 6.2 0.2 10.1 6.2 1.1 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 ArAE_2_N PF10337.9 ELR21220.1 - 0.27 10.2 3.1 0.36 9.8 3.1 1.1 1 0 0 1 1 1 0 Putative ER transporter, 6TM, N-terminal Dynamin_N PF00350.23 ELR21220.1 - 0.46 10.5 2.4 1.3 9.0 2.4 1.6 1 1 0 1 1 1 0 Dynamin family Atrophin-1 PF03154.15 ELR21220.1 - 1.1 7.4 6.5 1.6 6.9 6.5 1.1 1 0 0 1 1 1 0 Atrophin-1 family EIIBC-GUT_N PF03612.14 ELR21220.1 - 1.2 8.9 3.3 1.9 8.2 3.3 1.3 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus DUF719 PF05334.13 ELR21220.1 - 4.6 7.4 10.4 0.17 12.0 4.3 1.7 2 0 0 2 2 1 0 Protein of unknown function (DUF719) Methyltransf_16 PF10294.9 ELR21221.1 - 1.6e-13 50.8 0.0 2.4e-13 50.2 0.0 1.3 1 0 0 1 1 1 1 Lysine methyltransferase Cons_hypoth95 PF03602.15 ELR21221.1 - 4.6e-05 23.1 0.0 7.5e-05 22.4 0.0 1.3 1 0 0 1 1 1 1 Conserved hypothetical protein 95 MTS PF05175.14 ELR21221.1 - 0.06 12.9 0.1 0.1 12.1 0.1 1.4 1 0 0 1 1 1 0 Methyltransferase small domain PrmA PF06325.13 ELR21221.1 - 0.12 11.8 0.0 0.17 11.3 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Nodulin-like PF06813.13 ELR21222.1 - 5.1e-26 91.7 6.6 5.1e-26 91.7 6.6 1.8 2 0 0 2 2 2 1 Nodulin-like MFS_1 PF07690.16 ELR21222.1 - 2.3e-21 76.2 39.9 1.3e-12 47.3 17.1 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Cys_Met_Meta_PP PF01053.20 ELR21223.1 - 3.8e-29 101.4 0.0 9.3e-28 96.8 0.0 2.0 1 1 1 2 2 2 2 Cys/Met metabolism PLP-dependent enzyme Pox_F12L PF03337.13 ELR21223.1 - 0.077 11.1 0.0 0.34 9.0 0.0 1.7 2 0 0 2 2 2 0 Poxvirus F12L protein SBP_bac_3 PF00497.20 ELR21224.1 - 0.00018 21.1 0.0 0.31 10.4 0.0 2.2 2 0 0 2 2 2 2 Bacterial extracellular solute-binding proteins, family 3 Sacchrp_dh_NADP PF03435.18 ELR21224.1 - 0.00092 19.5 0.1 0.0015 18.7 0.1 1.3 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain LPAM_1 PF08139.12 ELR21224.1 - 0.023 15.2 0.5 0.073 13.6 0.5 1.9 1 0 0 1 1 1 0 Prokaryotic membrane lipoprotein lipid attachment site Cys_Met_Meta_PP PF01053.20 ELR21225.1 - 2.6e-24 85.5 0.1 3.4e-24 85.1 0.1 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_1_2 PF00155.21 ELR21225.1 - 0.016 14.4 0.0 0.021 14.0 0.0 1.1 1 0 0 1 1 1 0 Aminotransferase class I and II D123 PF07065.14 ELR21226.1 - 6.1e-18 65.0 7.6 1.9e-14 53.5 0.0 3.1 2 1 0 3 3 3 2 D123 R2K_2 PF18299.1 ELR21226.1 - 0.0001 22.2 0.2 0.0002 21.3 0.2 1.4 1 0 0 1 1 1 1 ATP-grasp domain, R2K clade family 2 R2K_3 PF14243.6 ELR21226.1 - 0.00061 19.8 0.2 0.0012 18.8 0.2 1.7 1 0 0 1 1 1 1 ATP-grasp domain, R2K clade family 3 SDA1 PF05285.12 ELR21226.1 - 0.26 10.6 5.6 0.35 10.2 5.6 1.1 1 0 0 1 1 1 0 SDA1 Cwf_Cwc_15 PF04889.12 ELR21226.1 - 0.48 10.1 9.5 0.77 9.4 9.5 1.3 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein RXT2_N PF08595.11 ELR21226.1 - 0.6 10.1 4.4 0.98 9.4 4.4 1.3 1 0 0 1 1 1 0 RXT2-like, N-terminal NOA36 PF06524.12 ELR21226.1 - 0.71 9.1 15.1 1.1 8.5 15.1 1.2 1 0 0 1 1 1 0 NOA36 protein PPP4R2 PF09184.11 ELR21226.1 - 1.1 8.7 6.9 1.6 8.2 6.9 1.2 1 0 0 1 1 1 0 PPP4R2 Sigma70_ner PF04546.13 ELR21226.1 - 1.9 8.3 9.4 3.8 7.4 9.4 1.4 1 0 0 1 1 1 0 Sigma-70, non-essential region RRN3 PF05327.11 ELR21226.1 - 4.2 5.8 6.5 5.7 5.3 6.5 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Sporozoite_P67 PF05642.11 ELR21226.1 - 5.7 4.9 4.8 7.7 4.5 4.8 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen FAM176 PF14851.6 ELR21226.1 - 6 6.5 7.4 11 5.7 7.4 1.3 1 0 0 1 1 1 0 FAM176 family CDC45 PF02724.14 ELR21226.1 - 7.7 4.7 8.4 11 4.1 8.4 1.1 1 0 0 1 1 1 0 CDC45-like protein DNA_pol_phi PF04931.13 ELR21226.1 - 8.3 4.4 19.2 12 3.8 19.2 1.1 1 0 0 1 1 1 0 DNA polymerase phi CENP-B_dimeris PF09026.10 ELR21226.1 - 9.2 6.7 20.7 8.1 6.9 18.9 1.8 2 0 0 2 2 1 0 Centromere protein B dimerisation domain GCIP PF13324.6 ELR21226.1 - 9.7 5.7 7.4 16 5.0 7.4 1.3 1 0 0 1 1 1 0 Grap2 and cyclin-D-interacting RasGEF_N_2 PF14663.6 ELR21228.1 - 7.9e-10 39.1 0.0 8.5e-10 39.0 0.0 1.0 1 0 0 1 1 1 1 Rapamycin-insensitive companion of mTOR RasGEF_N domain Peptidase_M24 PF00557.24 ELR21229.1 - 2.6e-57 193.9 0.0 3.2e-57 193.6 0.0 1.1 1 0 0 1 1 1 1 Metallopeptidase family M24 zf-C6H2 PF15801.5 ELR21229.1 - 2.6e-13 50.0 1.3 4.4e-13 49.3 1.3 1.4 1 0 0 1 1 1 1 zf-MYND-like zinc finger, mRNA-binding zf-MYND PF01753.18 ELR21229.1 - 0.00023 21.2 0.2 0.00049 20.1 0.2 1.6 1 0 0 1 1 1 1 MYND finger ACPS PF01648.20 ELR21229.1 - 0.086 13.0 0.0 0.26 11.4 0.0 1.7 2 0 0 2 2 2 0 4'-phosphopantetheinyl transferase superfamily WD40 PF00400.32 ELR21230.1 - 7.5e-39 131.0 17.8 3.7e-07 30.7 0.2 7.5 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ELR21230.1 - 9.6e-17 61.1 6.4 0.039 14.3 0.1 6.9 1 1 4 6 6 6 6 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 ELR21230.1 - 5.8e-08 32.8 0.4 0.001 19.0 0.1 3.3 2 1 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A Coatomer_WDAD PF04053.14 ELR21230.1 - 0.0056 15.8 0.1 0.22 10.5 0.0 2.2 1 1 1 2 2 2 2 Coatomer WD associated region Nucleoporin_N PF08801.11 ELR21230.1 - 0.01 14.6 3.0 0.034 12.9 0.2 2.9 2 1 1 3 3 3 0 Nup133 N terminal like Aa_trans PF01490.18 ELR21232.1 - 3e-57 194.2 25.4 3.7e-57 193.9 25.4 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein 7tm_6 PF02949.20 ELR21234.1 - 0.99 8.4 1.5 1.6 7.8 1.5 1.3 1 0 0 1 1 1 0 7tm Odorant receptor Exonuc_VII_L PF02601.15 ELR21234.1 - 3.1 7.3 11.1 4.2 6.8 11.1 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit Orf78 PF06024.12 ELR21235.1 - 3.6 8.0 0.0 3.6 8.0 0.0 2.9 3 0 0 3 3 3 0 Orf78 (ac78) DUF347 PF03988.12 ELR21236.1 - 0.21 11.8 0.0 0.21 11.8 0.0 2.0 2 0 0 2 2 2 0 Repeat of Unknown Function (DUF347) Phage_holin_3_6 PF07332.11 ELR21236.1 - 1.2 9.1 4.9 4.6 7.3 0.0 2.1 2 0 0 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III Myosin_head PF00063.21 ELR21237.1 - 2.9e-229 762.8 7.1 4.2e-229 762.2 7.1 1.3 1 0 0 1 1 1 1 Myosin head (motor domain) MyTH4 PF00784.17 ELR21237.1 - 1.6e-26 92.9 0.5 7.4e-26 90.8 0.2 2.3 2 0 0 2 2 2 1 MyTH4 domain SH3_9 PF14604.6 ELR21237.1 - 1.2e-08 34.7 0.3 3.3e-08 33.3 0.3 1.8 1 0 0 1 1 1 1 Variant SH3 domain WW PF00397.26 ELR21237.1 - 1.7e-07 31.2 3.3 1.7e-07 31.2 3.3 2.5 2 0 0 2 2 2 1 WW domain AAA_16 PF13191.6 ELR21237.1 - 0.07 13.5 0.0 0.07 13.5 0.0 3.4 4 1 0 4 4 4 0 AAA ATPase domain AAA_22 PF13401.6 ELR21237.1 - 0.11 12.7 0.3 1.1 9.6 0.0 2.9 2 0 0 2 2 2 0 AAA domain Hpr_kinase_C PF07475.12 ELR21237.1 - 0.12 11.9 0.1 16 5.0 0.0 3.0 2 0 0 2 2 2 0 HPr Serine kinase C-terminal domain IQ PF00612.27 ELR21237.1 - 0.14 12.0 1.2 0.51 10.3 1.2 2.0 1 0 0 1 1 1 0 IQ calmodulin-binding motif Ribonuclease PF00545.20 ELR21237.1 - 0.21 12.3 3.3 0.35 11.6 0.9 2.7 3 0 0 3 3 3 0 ribonuclease IMS PF00817.20 ELR21237.1 - 0.68 9.9 5.5 0.44 10.5 0.4 3.2 4 0 0 4 4 4 0 impB/mucB/samB family BAR PF03114.18 ELR21238.1 - 0.0006 19.5 5.1 0.15 11.7 2.2 2.2 2 0 0 2 2 2 2 BAR domain IMD PF08397.11 ELR21238.1 - 0.64 9.4 4.0 8.7 5.7 0.0 2.2 1 1 1 2 2 2 0 IRSp53/MIM homology domain Pkinase_Tyr PF07714.17 ELR21240.1 - 6.1e-58 196.1 0.0 1.1e-57 195.3 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ELR21240.1 - 7.3e-44 150.1 0.0 1.3e-43 149.3 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain COR PF16095.5 ELR21240.1 - 4.6e-33 114.7 0.3 1.5e-23 83.7 0.1 2.4 2 0 0 2 2 2 2 C-terminal of Roc, COR, domain Roc PF08477.13 ELR21240.1 - 2.2e-24 86.0 0.0 4.9e-22 78.4 0.0 3.6 2 2 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 ELR21240.1 - 7.3e-23 80.9 0.0 2.3e-15 56.5 0.0 2.6 2 0 0 2 2 2 2 Ras family LRR_8 PF13855.6 ELR21240.1 - 2.4e-10 40.0 5.8 4.8e-09 35.8 4.2 2.4 1 1 0 2 2 2 1 Leucine rich repeat LRR_4 PF12799.7 ELR21240.1 - 1.1e-09 38.4 3.3 3e-05 24.3 0.2 2.6 2 0 0 2 2 2 2 Leucine Rich repeats (2 copies) SH3_2 PF07653.17 ELR21240.1 - 6.4e-08 32.2 0.1 2e-07 30.6 0.1 1.9 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 ELR21240.1 - 5.3e-07 29.1 0.1 1.7e-06 27.5 0.1 1.9 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 ELR21240.1 - 7.7e-05 22.5 0.0 0.0025 17.6 0.0 2.6 2 0 0 2 2 2 1 Variant SH3 domain Arf PF00025.21 ELR21240.1 - 0.00016 21.1 0.0 0.00082 18.9 0.0 2.1 1 1 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 ELR21240.1 - 0.0044 16.4 0.0 0.011 15.1 0.0 1.6 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region PduV-EutP PF10662.9 ELR21240.1 - 0.0076 16.0 0.0 0.98 9.2 0.0 2.7 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation APH PF01636.23 ELR21240.1 - 0.024 14.6 0.0 0.29 11.0 0.0 2.4 2 0 0 2 2 2 0 Phosphotransferase enzyme family ADH_zinc_N PF00107.26 ELR21240.1 - 0.029 14.3 0.0 0.18 11.8 0.0 2.3 1 1 1 2 2 2 0 Zinc-binding dehydrogenase MMR_HSR1 PF01926.23 ELR21240.1 - 0.088 12.9 0.0 0.25 11.5 0.0 1.9 1 0 0 1 1 1 0 50S ribosome-binding GTPase LRR_1 PF00560.33 ELR21240.1 - 0.12 13.0 4.0 42 5.2 0.1 4.1 3 0 0 3 3 3 0 Leucine Rich Repeat TatD_DNase PF01026.21 ELR21241.1 - 4.8e-49 167.0 0.0 5.8e-49 166.8 0.0 1.0 1 0 0 1 1 1 1 TatD related DNase Androgen_recep PF02166.16 ELR21243.1 - 1.3 7.8 4.0 2.5 6.8 4.0 1.4 1 0 0 1 1 1 0 Androgen receptor DUF4407 PF14362.6 ELR21243.1 - 1.9 7.8 3.9 2.7 7.2 3.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) SID-1_RNA_chan PF13965.6 ELR21244.1 - 1.9e-87 294.1 12.0 2.4e-87 293.8 12.0 1.0 1 0 0 1 1 1 1 dsRNA-gated channel SID-1 Ceramidase PF05875.12 ELR21244.1 - 0.0013 18.2 21.3 0.013 14.9 6.6 2.3 1 1 1 2 2 2 2 Ceramidase SR-25 PF10500.9 ELR21245.1 - 0.0001 22.0 5.3 0.00012 21.7 5.3 1.1 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein AP3D1 PF06375.11 ELR21245.1 - 0.0053 17.0 4.9 0.0065 16.7 4.9 1.2 1 0 0 1 1 1 1 AP-3 complex subunit delta-1 Microcephalin PF12258.8 ELR21245.1 - 0.017 14.4 8.1 0.019 14.2 8.1 1.0 1 0 0 1 1 1 0 Microcephalin protein DUF4551 PF15087.6 ELR21245.1 - 0.043 12.7 2.8 0.049 12.5 2.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) DUF3464 PF11947.8 ELR21245.1 - 1.4 8.6 4.4 2.3 8.0 4.4 1.3 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 Na_sulph_symp PF00939.19 ELR21246.1 - 9.7e-66 222.7 12.3 4.8e-65 220.4 12.3 2.1 1 1 0 1 1 1 1 Sodium:sulfate symporter transmembrane region CitMHS PF03600.16 ELR21246.1 - 5.1e-29 101.4 33.6 2.2e-15 56.7 4.8 3.4 2 2 1 3 3 3 3 Citrate transporter Abhydrolase_1 PF00561.20 ELR21247.1 - 6.3e-13 48.9 0.0 1.1e-12 48.2 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 ELR21247.1 - 8e-09 36.4 5.6 8e-09 36.4 5.6 2.0 2 0 0 2 2 2 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 ELR21247.1 - 1.5e-08 34.2 0.1 2.7e-08 33.4 0.1 1.4 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Thioesterase PF00975.20 ELR21247.1 - 5.7e-05 23.3 0.0 0.00018 21.7 0.0 1.8 1 1 0 1 1 1 1 Thioesterase domain DUF3040 PF11239.8 ELR21247.1 - 0.036 14.3 0.4 0.1 12.9 0.4 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3040) Ndr PF03096.14 ELR21247.1 - 0.064 12.0 0.0 0.091 11.4 0.0 1.1 1 0 0 1 1 1 0 Ndr family DUF2920 PF11144.8 ELR21247.1 - 0.14 11.3 0.0 0.2 10.8 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2920) Caa3_CtaG PF09678.10 ELR21247.1 - 2.1 7.7 6.7 1.1 8.7 0.7 2.2 2 0 0 2 2 2 0 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG) CrgA PF06781.12 ELR21248.1 - 0.097 12.7 0.0 0.14 12.2 0.0 1.2 1 0 0 1 1 1 0 Cell division protein CrgA Arm PF00514.23 ELR21249.1 - 1.1e-10 41.2 11.1 2.2e-05 24.3 0.2 6.2 6 0 0 6 6 6 3 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.6 ELR21249.1 - 2.6e-06 27.8 16.3 0.036 14.6 0.1 6.5 4 1 2 6 6 6 2 HEAT-like repeat HEAT_2 PF13646.6 ELR21249.1 - 3.5e-06 27.3 10.5 0.032 14.6 0.2 4.7 3 1 2 5 5 5 3 HEAT repeats HEAT PF02985.22 ELR21249.1 - 0.00027 20.9 8.7 0.0053 16.9 0.1 4.9 5 0 0 5 5 5 1 HEAT repeat IFRD PF05004.13 ELR21249.1 - 0.042 13.0 1.8 2.3 7.2 0.1 2.7 2 1 0 2 2 2 0 Interferon-related developmental regulator (IFRD) IBN_N PF03810.19 ELR21249.1 - 0.045 13.7 0.1 13 5.8 0.0 3.3 3 0 0 3 3 3 0 Importin-beta N-terminal domain F-box-like PF12937.7 ELR21250.1 - 6.9e-10 38.7 1.4 1.4e-09 37.7 1.4 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ELR21250.1 - 2.2e-06 27.4 1.1 4.4e-05 23.2 1.2 2.4 1 1 1 2 2 2 2 F-box domain F-box_4 PF15966.5 ELR21250.1 - 0.0034 17.3 0.0 0.0053 16.6 0.0 1.3 1 0 0 1 1 1 1 F-box F-box_5 PF18511.1 ELR21250.1 - 0.32 10.6 3.8 1.7 8.3 3.8 2.0 1 1 0 1 1 1 0 F-box NUDIX PF00293.28 ELR21251.1 - 4e-12 46.3 0.1 6.5e-12 45.6 0.1 1.3 1 0 0 1 1 1 1 NUDIX domain zf-Di19 PF05605.12 ELR21251.1 - 0.0013 19.0 4.3 0.0021 18.3 4.3 1.3 1 0 0 1 1 1 1 Drought induced 19 protein (Di19), zinc-binding AATase PF07247.12 ELR21252.1 - 4.6e-06 25.5 0.0 0.0082 14.7 0.0 2.2 2 0 0 2 2 2 2 Alcohol acetyltransferase PRKCSH_1 PF13015.6 ELR21254.1 - 0.00029 20.5 0.0 0.00042 20.0 0.0 1.2 1 0 0 1 1 1 1 Glucosidase II beta subunit-like protein DUF3246 PF11596.8 ELR21255.1 - 2.2 7.7 6.7 3.1 7.2 0.2 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF3246) Spt20 PF12090.8 ELR21255.1 - 7.1 6.2 15.2 1.4 8.5 5.9 2.4 2 0 0 2 2 2 0 Spt20 family E1-E2_ATPase PF00122.20 ELR21256.1 - 1.3e-49 168.2 0.9 3.8e-49 166.7 0.9 1.9 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase PF00702.26 ELR21256.1 - 5.6e-46 157.5 0.5 1.1e-45 156.6 0.5 1.5 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HMA PF00403.26 ELR21256.1 - 2.8e-35 120.6 2.7 4e-16 59.2 0.0 3.5 3 0 0 3 3 3 3 Heavy-metal-associated domain Hydrolase_3 PF08282.12 ELR21256.1 - 0.0019 18.0 0.9 0.0093 15.7 0.8 2.1 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 ELR21256.1 - 0.0024 18.3 0.1 0.011 16.2 0.0 2.0 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Fer2_BFD PF04324.15 ELR21256.1 - 0.031 14.6 10.1 1.3 9.4 0.1 4.0 4 0 0 4 4 4 0 BFD-like [2Fe-2S] binding domain DUF812 PF05667.11 ELR21257.1 - 5.7e-34 118.0 0.0 6.3e-34 117.8 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF812) Nsp3_PL2pro PF12124.8 ELR21257.1 - 0.15 11.9 0.5 0.22 11.3 0.1 1.5 2 0 0 2 2 2 0 Coronavirus polyprotein cleavage domain DUF812 PF05667.11 ELR21258.1 - 1.6e-14 53.8 0.0 1.7e-14 53.7 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF812) CLU PF13236.6 ELR21259.1 - 1.1e-10 41.7 0.0 1.4e-10 41.4 0.0 1.0 1 0 0 1 1 1 1 Clustered mitochondria Methyltransf_11 PF08241.12 ELR21261.1 - 6.1e-11 42.8 0.0 5.8e-07 30.1 0.0 3.0 3 1 0 3 3 3 2 Methyltransferase domain Methyltransf_31 PF13847.6 ELR21261.1 - 2.3e-10 40.5 0.1 2e-07 30.9 0.0 2.9 2 1 0 2 2 2 2 Methyltransferase domain Methyltransf_25 PF13649.6 ELR21261.1 - 3.7e-09 37.2 0.0 1.1e-06 29.3 0.0 3.3 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 ELR21261.1 - 3.5e-08 33.4 0.1 3.2e-07 30.3 0.1 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ELR21261.1 - 1.5e-06 28.8 0.2 1.8e-05 25.4 0.0 2.5 2 1 0 2 2 2 1 Methyltransferase domain MTS PF05175.14 ELR21261.1 - 0.0021 17.7 0.0 0.0036 16.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_32 PF13679.6 ELR21261.1 - 0.013 15.5 0.3 0.032 14.2 0.3 1.8 1 1 0 1 1 1 0 Methyltransferase domain AdoMet_MTase PF07757.13 ELR21261.1 - 0.015 15.6 0.0 0.024 14.9 0.0 1.3 1 0 0 1 1 1 0 Predicted AdoMet-dependent methyltransferase DUF4820 PF16091.5 ELR21261.1 - 0.057 12.8 1.2 0.1 12.0 1.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) Methyltransf_29 PF03141.16 ELR21261.1 - 0.15 10.6 0.0 0.48 8.9 0.0 1.7 2 0 0 2 2 2 0 Putative S-adenosyl-L-methionine-dependent methyltransferase Peptidase_C1 PF00112.23 ELR21263.1 - 7.7e-51 173.3 1.1 1.1e-50 172.7 1.1 1.2 1 0 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.12 ELR21263.1 - 2.1e-15 56.9 3.3 3.5e-15 56.2 3.3 1.4 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Peptidase_C1_2 PF03051.15 ELR21263.1 - 0.049 12.4 0.2 0.075 11.8 0.2 1.2 1 0 0 1 1 1 0 Peptidase C1-like family DnaJ PF00226.31 ELR21264.1 - 9.7e-06 25.6 0.0 1.6e-05 24.9 0.0 1.3 1 0 0 1 1 1 1 DnaJ domain Pam16 PF03656.13 ELR21264.1 - 0.00018 21.5 0.0 0.00021 21.3 0.0 1.1 1 0 0 1 1 1 1 Pam16 Ependymin PF00811.18 ELR21265.1 - 3e-06 27.5 0.1 5e-06 26.8 0.1 1.3 1 0 0 1 1 1 1 Ependymin DUF4435 PF14491.6 ELR21266.1 - 0.00013 22.0 0.0 0.00032 20.7 0.0 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF4435) AAA_21 PF13304.6 ELR21266.1 - 0.029 14.2 0.0 0.051 13.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system DUF3446 PF11928.8 ELR21266.1 - 0.068 13.5 23.6 0.53 10.6 23.6 2.2 1 1 0 1 1 1 0 Early growth response N-terminal domain Ribosomal_S6 PF01250.17 ELR21266.1 - 0.11 12.8 0.0 22 5.4 0.0 3.3 2 1 0 3 3 3 0 Ribosomal protein S6 AAA_21 PF13304.6 ELR21267.1 - 4.9e-07 29.8 0.3 0.0026 17.6 0.0 2.5 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_16 PF13191.6 ELR21267.1 - 1.6e-06 28.6 1.0 1.1e-05 25.9 0.0 2.8 2 1 0 2 2 2 1 AAA ATPase domain SMC_N PF02463.19 ELR21267.1 - 0.00015 21.2 0.0 0.081 12.3 0.0 2.4 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain ABC_tran PF00005.27 ELR21267.1 - 0.00019 22.0 0.1 0.0018 18.8 0.0 2.7 2 1 0 2 2 2 1 ABC transporter AAA_22 PF13401.6 ELR21267.1 - 0.0016 18.7 0.1 0.0064 16.8 0.1 2.1 1 1 0 1 1 1 1 AAA domain NACHT PF05729.12 ELR21267.1 - 0.0021 18.0 0.1 0.091 12.7 0.1 2.5 2 0 0 2 2 2 1 NACHT domain AAA PF00004.29 ELR21267.1 - 0.0069 16.8 0.1 0.043 14.2 0.1 2.5 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) IstB_IS21 PF01695.17 ELR21267.1 - 0.015 15.1 0.0 0.13 12.0 0.0 2.4 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA_7 PF12775.7 ELR21267.1 - 0.063 12.8 0.0 0.14 11.7 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_23 PF13476.6 ELR21267.1 - 0.077 13.5 1.8 1.2 9.6 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_15 PF13175.6 ELR21267.1 - 0.14 11.9 0.2 6.9 6.3 0.0 2.9 3 0 0 3 3 3 0 AAA ATPase domain ATP-synt_E PF05680.12 ELR21267.1 - 0.28 11.5 3.0 0.56 10.6 0.1 2.6 2 0 0 2 2 2 0 ATP synthase E chain CBFB_NFYA PF02045.15 ELR21268.1 - 2.5e-08 34.4 7.1 2.5e-08 34.4 0.9 2.6 2 0 0 2 2 2 1 CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B THUMP PF02926.17 ELR21269.1 - 1e-10 41.9 0.0 1.9e-10 41.0 0.0 1.5 1 0 0 1 1 1 1 THUMP domain YozE_SAM_like PF06855.12 ELR21269.1 - 0.11 12.6 0.1 0.3 11.3 0.1 1.6 1 0 0 1 1 1 0 YozE SAM-like fold APH PF01636.23 ELR21270.1 - 2.1e-40 139.1 0.0 3.7e-40 138.4 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Acyl-CoA_dh_1 PF00441.24 ELR21270.1 - 6.2e-34 117.4 4.3 1.5e-33 116.2 4.3 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 ELR21270.1 - 1.2e-21 76.7 0.0 2.5e-21 75.7 0.0 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.11 ELR21270.1 - 4.2e-13 49.7 1.1 9.6e-13 48.6 1.1 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.16 ELR21270.1 - 1.5e-11 45.0 0.0 3.2e-11 43.9 0.0 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain RIO1 PF01163.22 ELR21270.1 - 0.00075 19.1 0.0 1 8.9 0.0 2.3 2 0 0 2 2 2 2 RIO1 family EcKinase PF02958.20 ELR21270.1 - 0.0036 16.7 0.0 0.007 15.7 0.0 1.4 1 0 0 1 1 1 1 Ecdysteroid kinase ACBP PF00887.19 ELR21271.1 - 4.7e-17 62.0 0.7 6.4e-17 61.5 0.6 1.4 1 1 0 1 1 1 1 Acyl CoA binding protein TPR_11 PF13414.6 ELR21271.1 - 0.0054 16.4 0.4 0.011 15.4 0.4 1.5 1 0 0 1 1 1 1 TPR repeat TPR_21 PF09976.9 ELR21271.1 - 0.045 13.4 3.2 0.31 10.7 0.1 2.1 2 0 0 2 2 2 0 Tetratricopeptide repeat-like domain SCO1-SenC PF02630.14 ELR21272.1 - 1e-47 161.4 0.0 1.4e-47 160.9 0.0 1.2 1 0 0 1 1 1 1 SCO1/SenC Redoxin PF08534.10 ELR21272.1 - 0.0066 16.2 0.1 0.073 12.8 0.1 2.1 1 1 0 1 1 1 1 Redoxin AhpC-TSA PF00578.21 ELR21272.1 - 0.071 13.0 0.0 0.16 11.9 0.0 1.5 1 0 0 1 1 1 0 AhpC/TSA family Thioredoxin_8 PF13905.6 ELR21272.1 - 0.072 13.4 0.0 0.13 12.6 0.0 1.5 1 0 0 1 1 1 0 Thioredoxin-like DUF4381 PF14316.6 ELR21272.1 - 0.15 12.3 0.1 0.31 11.3 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) Cupin_8 PF13621.6 ELR21276.1 - 5.7e-08 32.8 0.0 7.2e-08 32.5 0.0 1.1 1 0 0 1 1 1 1 Cupin-like domain Cupin_8 PF13621.6 ELR21277.1 - 6.6e-61 206.2 0.4 7.5e-61 206.0 0.4 1.0 1 0 0 1 1 1 1 Cupin-like domain Cupin_2 PF07883.11 ELR21277.1 - 0.049 13.4 0.2 4.3 7.1 0.0 2.3 2 0 0 2 2 2 0 Cupin domain JmjC PF02373.22 ELR21277.1 - 0.053 14.0 0.1 0.2 12.1 0.1 2.1 1 1 0 1 1 1 0 JmjC domain, hydroxylase DUF2935 PF11155.8 ELR21277.1 - 0.095 13.0 0.0 0.16 12.3 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF2935) Methyltransf_11 PF08241.12 ELR21278.1 - 5.9e-11 42.9 0.1 1.8e-06 28.5 0.0 3.4 3 1 0 3 3 3 2 Methyltransferase domain Methyltransf_31 PF13847.6 ELR21278.1 - 1.4e-10 41.1 0.1 1.6e-07 31.2 0.0 2.9 2 1 0 2 2 2 2 Methyltransferase domain Methyltransf_25 PF13649.6 ELR21278.1 - 2.1e-09 37.9 0.0 1.8e-05 25.3 0.0 3.4 3 0 0 3 3 3 1 Methyltransferase domain Methyltransf_23 PF13489.6 ELR21278.1 - 3e-08 33.7 0.1 3.3e-07 30.3 0.1 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ELR21278.1 - 1.2e-06 29.2 0.1 1.6e-05 25.6 0.0 2.6 2 1 1 3 3 3 1 Methyltransferase domain MTS PF05175.14 ELR21278.1 - 0.0013 18.3 0.0 0.0023 17.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain AdoMet_MTase PF07757.13 ELR21278.1 - 0.0045 17.3 0.0 0.0072 16.7 0.0 1.3 1 0 0 1 1 1 1 Predicted AdoMet-dependent methyltransferase Methyltransf_32 PF13679.6 ELR21278.1 - 0.0045 17.0 0.3 0.0096 15.9 0.3 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_29 PF03141.16 ELR21278.1 - 0.08 11.5 0.0 0.38 9.2 0.0 1.9 2 0 0 2 2 2 0 Putative S-adenosyl-L-methionine-dependent methyltransferase DUF4820 PF16091.5 ELR21278.1 - 0.17 11.2 1.3 0.3 10.4 1.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) Ubie_methyltran PF01209.18 ELR21278.1 - 0.18 11.1 0.0 17 4.7 0.0 2.7 3 0 0 3 3 3 0 ubiE/COQ5 methyltransferase family CLU PF13236.6 ELR21279.1 - 5.3e-20 72.2 0.0 6e-20 72.0 0.0 1.0 1 0 0 1 1 1 1 Clustered mitochondria G8 PF10162.9 ELR21280.1 - 3.9e-21 75.4 0.0 8e-21 74.4 0.0 1.6 1 0 0 1 1 1 1 G8 domain Amnionless PF14828.6 ELR21280.1 - 0.032 13.1 0.0 0.049 12.5 0.0 1.2 1 0 0 1 1 1 0 Amnionless FhuF_C PF11575.8 ELR21281.1 - 0.11 12.4 2.3 0.23 11.4 1.2 2.1 2 0 0 2 2 2 0 FhuF 2Fe-2S C-terminal domain DUF4698 PF15769.5 ELR21281.1 - 0.17 10.9 0.2 0.16 11.0 0.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4698) PIP5K PF01504.18 ELR21283.1 - 2.5e-81 272.9 0.0 4.1e-81 272.2 0.0 1.3 1 0 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase MIT PF04212.18 ELR21283.1 - 7.1e-06 26.0 1.7 1.7e-05 24.8 1.7 1.6 1 0 0 1 1 1 1 MIT (microtubule interacting and transport) domain TAtT PF16811.5 ELR21283.1 - 0.11 11.7 0.0 0.21 10.9 0.0 1.3 1 0 0 1 1 1 0 TRAP transporter T-component RNF220 PF15926.5 ELR21283.1 - 0.23 11.1 0.0 0.23 11.1 0.0 2.6 3 0 0 3 3 3 0 E3 ubiquitin-protein ligase RNF220 Ras PF00071.22 ELR21284.1 - 8e-40 136.1 0.2 1e-39 135.8 0.2 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR21284.1 - 1e-26 93.5 0.1 1.6e-26 92.9 0.1 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR21284.1 - 1.6e-11 44.0 0.1 2.2e-11 43.5 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 ELR21284.1 - 1.3e-06 27.9 0.0 1.8e-06 27.5 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit GTP_EFTU PF00009.27 ELR21284.1 - 1.1e-05 25.0 0.2 3.3e-05 23.5 0.2 1.7 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 ELR21284.1 - 0.00026 21.1 0.0 0.00045 20.3 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 ELR21284.1 - 0.0046 16.3 0.0 0.0059 16.0 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region ATP_bind_1 PF03029.17 ELR21284.1 - 0.048 13.4 0.6 2.6 7.8 0.0 2.3 1 1 1 2 2 2 0 Conserved hypothetical ATP binding protein FAP PF07174.11 ELR21285.1 - 3.2 7.1 22.2 5.4 6.4 22.2 1.3 1 0 0 1 1 1 0 Fibronectin-attachment protein (FAP) F-box-like PF12937.7 ELR21286.1 - 0.065 13.1 0.9 0.13 12.2 0.9 1.5 1 0 0 1 1 1 0 F-box-like WD40 PF00400.32 ELR21287.1 - 3.5e-10 40.3 14.8 2.2e-06 28.3 0.4 6.0 6 0 0 6 6 6 2 WD domain, G-beta repeat F-box-like PF12937.7 ELR21287.1 - 2.2e-08 33.8 0.0 4.8e-08 32.8 0.0 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ELR21287.1 - 3.4e-07 30.0 0.1 1.1e-06 28.4 0.0 1.9 2 0 0 2 2 2 1 F-box domain WD40_like PF17005.5 ELR21287.1 - 6.6e-05 22.4 0.0 0.00037 19.9 0.0 2.0 2 0 0 2 2 2 1 WD40-like domain PQQ_3 PF13570.6 ELR21287.1 - 0.0087 16.5 0.0 66 4.2 0.0 4.0 3 0 0 3 3 3 0 PQQ-like domain F-box PF00646.33 ELR21288.1 - 1.4e-07 31.2 0.0 2.8e-06 27.1 0.0 2.4 2 0 0 2 2 2 1 F-box domain F-box-like PF12937.7 ELR21288.1 - 2.1e-07 30.7 0.0 6.5e-07 29.1 0.0 1.9 1 0 0 1 1 1 1 F-box-like WDCP PF15390.6 ELR21289.1 - 0.019 13.4 0.1 0.023 13.1 0.1 1.1 1 0 0 1 1 1 0 WD repeat and coiled-coil-containing protein family DUF5102 PF17104.5 ELR21289.1 - 0.085 12.9 0.6 0.1 12.6 0.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF5102) CRCB PF02537.15 ELR21290.1 - 2.5e-14 53.4 21.2 3.5e-09 36.9 5.7 2.3 2 0 0 2 2 2 2 CrcB-like protein, Camphor Resistance (CrcB) DUF4956 PF16316.5 ELR21290.1 - 0.11 12.2 0.8 18 5.0 0.0 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF4956) Costars PF14705.6 ELR21291.1 - 0.00053 20.1 0.0 0.00075 19.6 0.0 1.2 1 0 0 1 1 1 1 Costars PIP5K PF01504.18 ELR21292.1 - 5e-75 252.3 0.0 9.6e-75 251.3 0.0 1.5 1 0 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase GRAM PF02893.20 ELR21292.1 - 1.9e-32 111.5 0.1 1e-16 60.8 0.1 2.5 2 0 0 2 2 2 2 GRAM domain NmrA PF05368.13 ELR21292.1 - 7.5e-19 68.2 0.0 2.6e-15 56.6 0.0 2.2 2 0 0 2 2 2 2 NmrA-like family NAD_binding_10 PF13460.6 ELR21292.1 - 4.6e-15 56.0 0.1 1.1e-14 54.8 0.1 1.5 1 0 0 1 1 1 1 NAD(P)H-binding EF-hand_1 PF00036.32 ELR21292.1 - 9e-13 46.8 0.0 0.0023 17.4 0.0 5.0 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.6 ELR21292.1 - 6e-12 44.5 0.0 0.15 12.1 0.0 5.2 4 0 0 4 4 4 3 EF-hand domain EF-hand_7 PF13499.6 ELR21292.1 - 5.2e-09 36.4 0.1 1.6e-05 25.3 0.0 4.0 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_8 PF13833.6 ELR21292.1 - 6.5e-08 32.3 1.0 0.023 14.5 0.3 3.7 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.6 ELR21292.1 - 0.015 14.8 2.3 47 3.7 0.0 4.6 4 0 0 4 4 4 0 EF hand EF-hand_9 PF14658.6 ELR21292.1 - 0.1 12.9 0.0 9.5 6.6 0.0 3.5 4 0 0 4 4 4 0 EF-hand domain PI3_PI4_kinase PF00454.27 ELR21293.1 - 2.8e-51 174.7 0.0 4.8e-50 170.7 0.0 2.7 1 1 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase PI3Ka PF00613.20 ELR21293.1 - 5.2e-50 169.4 0.6 1.7e-49 167.7 0.2 2.0 2 0 0 2 2 2 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) PI3K_C2 PF00792.24 ELR21293.1 - 6.5e-21 74.7 0.0 6.5e-21 74.7 0.0 2.0 2 0 0 2 2 2 1 Phosphoinositide 3-kinase C2 PI3K_rbd PF00794.18 ELR21293.1 - 1.8e-17 63.4 1.3 3.8e-14 52.8 0.1 3.6 3 0 0 3 3 3 2 PI3-kinase family, ras-binding domain DUF4135 PF13575.6 ELR21293.1 - 0.0049 16.2 0.0 0.013 14.8 0.0 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF4135) WD40 PF00400.32 ELR21295.1 - 7.7e-09 36.0 4.3 0.0019 19.0 0.1 4.5 5 0 0 5 5 5 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ELR21295.1 - 1e-06 28.9 0.1 0.034 14.4 0.0 3.8 2 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ELR21295.1 - 0.015 14.3 0.0 1.4 7.8 0.0 2.5 1 1 1 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein CPSF_A PF03178.15 ELR21295.1 - 0.064 12.6 0.0 2.5 7.3 0.0 2.2 2 0 0 2 2 2 0 CPSF A subunit region PD40 PF07676.12 ELR21295.1 - 0.092 12.7 0.0 0.63 10.1 0.0 2.1 2 0 0 2 2 2 0 WD40-like Beta Propeller Repeat DUF1513 PF07433.11 ELR21295.1 - 0.17 10.9 0.1 1.4 7.9 0.1 2.1 2 1 0 2 2 2 0 Protein of unknown function (DUF1513) Ribosomal_S17e PF00833.18 ELR21296.1 - 4e-62 207.6 0.1 5.1e-62 207.2 0.1 1.1 1 0 0 1 1 1 1 Ribosomal S17 Sec1 PF00995.23 ELR21297.1 - 3.1e-102 343.7 0.0 3.9e-102 343.3 0.0 1.0 1 0 0 1 1 1 1 Sec1 family Sec1 PF00995.23 ELR21298.1 - 1.7e-11 44.1 0.0 1.7e-11 44.1 0.0 1.1 1 0 0 1 1 1 1 Sec1 family Inhibitor_I78 PF11720.8 ELR21298.1 - 0.066 13.3 0.1 0.25 11.4 0.1 1.8 2 0 0 2 2 2 0 Peptidase inhibitor I78 family zf-CCHC PF00098.23 ELR21299.1 - 1.4e-34 116.6 28.1 1.3e-08 34.5 2.4 4.6 4 0 0 4 4 4 4 Zinc knuckle UDG PF03167.19 ELR21299.1 - 4.1e-17 62.6 0.0 6.6e-17 61.9 0.0 1.2 1 0 0 1 1 1 1 Uracil DNA glycosylase superfamily zf-GRF PF06839.12 ELR21299.1 - 6.3e-17 61.4 3.3 6.3e-17 61.4 3.3 3.2 4 0 0 4 4 4 1 GRF zinc finger zf-CCHC_3 PF13917.6 ELR21299.1 - 1.2e-10 41.1 15.8 0.0013 18.7 1.2 4.4 4 0 0 4 4 4 4 Zinc knuckle zf-CCHC_5 PF14787.6 ELR21299.1 - 3e-10 39.6 27.1 0.0063 16.2 0.7 4.4 4 0 0 4 4 4 4 GAG-polyprotein viral zinc-finger zf-CCHC_2 PF13696.6 ELR21299.1 - 5.2e-10 38.9 27.0 0.0011 18.8 0.7 4.5 4 0 0 4 4 4 4 Zinc knuckle zf-CCHC_4 PF14392.6 ELR21299.1 - 0.00015 21.4 13.7 2 8.2 0.2 4.4 4 0 0 4 4 4 4 Zinc knuckle eIF3g PF12353.8 ELR21299.1 - 0.34 11.3 0.1 0.34 11.3 0.1 4.3 4 0 0 4 4 4 0 Eukaryotic translation initiation factor 3 subunit G zf-C2H2_10 PF16588.5 ELR21299.1 - 1.6 8.6 16.3 10 6.0 0.9 4.4 4 0 0 4 4 4 0 C2H2 zinc-finger CorA PF01544.18 ELR21300.1 - 0.09 12.1 3.3 0.16 11.3 3.3 1.4 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein ECH_2 PF16113.5 ELR21302.1 - 6e-92 308.7 0.0 6e-92 308.7 0.0 3.7 3 1 2 5 5 5 1 Enoyl-CoA hydratase/isomerase ECH_1 PF00378.20 ELR21302.1 - 1.4e-21 76.9 2.9 4.6e-18 65.4 0.0 3.5 4 0 0 4 4 4 2 Enoyl-CoA hydratase/isomerase TRAPPC9-Trs120 PF08626.11 ELR21303.1 - 3.6e-66 223.4 0.0 1.1e-22 79.4 0.0 6.0 3 3 2 5 5 5 5 Transport protein Trs120 or TRAPPC9, TRAPP II complex subunit TRAPPC-Trs85 PF12739.7 ELR21303.1 - 0.01 14.8 8.5 0.016 14.2 8.5 1.2 1 0 0 1 1 1 0 ER-Golgi trafficking TRAPP I complex 85 kDa subunit Phage_int_SAM_1 PF02899.17 ELR21303.1 - 0.055 13.8 0.8 0.12 12.7 0.8 1.5 1 0 0 1 1 1 0 Phage integrase, N-terminal SAM-like domain TRAPPC9-Trs120 PF08626.11 ELR21304.1 - 6.5e-05 20.5 0.0 7.1e-05 20.4 0.0 1.0 1 0 0 1 1 1 1 Transport protein Trs120 or TRAPPC9, TRAPP II complex subunit PX PF00787.24 ELR21307.1 - 2.1e-08 34.1 0.4 2.1e-05 24.5 0.0 2.6 2 0 0 2 2 2 2 PX domain Rick_17kDa_Anti PF05433.15 ELR21307.1 - 0.037 13.9 9.1 0.11 12.3 9.1 1.9 1 0 0 1 1 1 0 Glycine zipper 2TM domain Gly-zipper_Omp PF13488.6 ELR21307.1 - 0.42 10.7 12.9 0.34 10.9 10.2 2.3 2 0 0 2 2 2 0 Glycine zipper Ycf54 PF10674.9 ELR21307.1 - 1.5 9.2 3.7 0.67 10.3 0.2 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2488) BTB PF00651.31 ELR21308.1 - 4.4e-25 88.1 0.8 6.7e-12 45.6 0.1 3.7 3 1 0 3 3 3 2 BTB/POZ domain Ank_4 PF13637.6 ELR21308.1 - 9.6e-13 48.4 0.0 1.6e-07 31.7 0.0 2.8 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 ELR21308.1 - 6.1e-08 33.1 0.0 2.6e-07 31.1 0.0 2.0 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 ELR21308.1 - 4.5e-06 26.6 0.0 0.0045 17.4 0.0 3.8 3 0 0 3 3 3 1 Ankyrin repeat Ank_5 PF13857.6 ELR21308.1 - 6.7e-05 23.1 0.0 0.0008 19.7 0.0 2.6 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank PF00023.30 ELR21308.1 - 0.012 16.0 0.0 0.12 12.8 0.0 2.6 3 0 0 3 3 3 0 Ankyrin repeat DUF3342 PF11822.8 ELR21308.1 - 0.13 12.5 0.1 7.1 6.9 0.0 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF3342) CDC45 PF02724.14 ELR21308.1 - 2.7 6.2 12.9 0.17 10.1 6.8 1.8 2 0 0 2 2 2 0 CDC45-like protein RR_TM4-6 PF06459.12 ELR21308.1 - 2.7 7.7 6.5 0.4 10.5 0.3 2.1 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 RHH_1 PF01402.21 ELR21308.1 - 7.3 6.7 8.7 4.2 7.5 0.2 3.7 3 0 0 3 3 3 0 Ribbon-helix-helix protein, copG family Ribosomal_L22 PF00237.19 ELR21309.1 - 2.1e-18 66.4 1.0 3.5e-18 65.7 1.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L22p/L17e Carboxyl_trans PF01039.22 ELR21310.1 - 5.1e-115 384.9 0.0 3.1e-80 270.2 0.0 2.2 1 1 1 2 2 2 2 Carboxyl transferase domain WD40 PF00400.32 ELR21311.1 - 2.3e-31 107.3 5.4 2.5e-09 37.6 0.3 7.9 7 1 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ELR21311.1 - 2.7e-12 46.8 0.0 0.0047 17.2 0.0 5.1 3 1 2 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain GAS PF13851.6 ELR21311.1 - 0.024 14.0 0.3 0.038 13.3 0.3 1.2 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding Shugoshin_N PF07558.11 ELR21311.1 - 0.055 13.3 0.4 0.094 12.6 0.4 1.3 1 0 0 1 1 1 0 Shugoshin N-terminal coiled-coil region DivIC PF04977.15 ELR21311.1 - 0.065 13.0 0.5 0.12 12.2 0.5 1.3 1 0 0 1 1 1 0 Septum formation initiator BBS2_Mid PF14783.6 ELR21311.1 - 0.12 12.4 0.1 32 4.6 0.0 2.9 3 0 0 3 3 3 0 Ciliary BBSome complex subunit 2, middle region betaPIX_CC PF16523.5 ELR21311.1 - 0.13 12.1 0.6 0.3 10.9 0.6 1.5 1 0 0 1 1 1 0 betaPIX coiled coil IFP_35_N PF07334.13 ELR21311.1 - 0.25 11.4 1.2 0.58 10.3 1.2 1.6 1 0 0 1 1 1 0 Interferon-induced 35 kDa protein (IFP 35) N-terminus Arm PF00514.23 ELR21312.1 - 0.00011 22.1 1.7 0.85 9.8 0.2 3.9 4 0 0 4 4 4 2 Armadillo/beta-catenin-like repeat Xpo1 PF08389.12 ELR21312.1 - 0.097 12.7 0.1 4.6 7.3 0.0 2.5 2 0 0 2 2 2 0 Exportin 1-like protein DUF4763 PF15960.5 ELR21312.1 - 0.12 11.6 6.5 0.2 10.9 6.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4763) Jnk-SapK_ap_N PF09744.9 ELR21312.1 - 0.13 12.5 7.0 0.26 11.5 7.0 1.5 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 Zn_clus PF00172.18 ELR21312.1 - 0.17 12.0 2.0 0.38 10.9 2.0 1.6 1 0 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain Atg14 PF10186.9 ELR21312.1 - 1.1 8.2 4.8 1.8 7.6 4.8 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 PAS PF00989.25 ELR21313.1 - 0.0069 16.4 0.0 0.013 15.5 0.0 1.4 1 0 0 1 1 1 1 PAS fold PAS_9 PF13426.7 ELR21313.1 - 0.0077 16.5 0.0 0.015 15.6 0.0 1.5 1 0 0 1 1 1 1 PAS domain SR-25 PF10500.9 ELR21313.1 - 0.012 15.2 2.0 0.018 14.7 2.0 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein DUF2381 PF09544.10 ELR21313.1 - 0.083 12.4 0.1 0.13 11.8 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2381) PAS_3 PF08447.12 ELR21313.1 - 0.2 11.9 0.0 0.45 10.8 0.0 1.6 1 0 0 1 1 1 0 PAS fold MAGE_N PF12440.8 ELR21313.1 - 0.34 11.6 8.2 0.29 11.9 6.1 1.9 2 0 0 2 2 2 0 Melanoma associated antigen family N terminal Herpes_pp85 PF04637.12 ELR21313.1 - 1.7 7.0 5.0 2.4 6.5 5.0 1.1 1 0 0 1 1 1 0 Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25) PAS PF00989.25 ELR21314.1 - 6.4e-05 22.9 0.1 0.0011 18.9 0.0 2.4 2 0 0 2 2 2 1 PAS fold LRRFIP PF09738.9 ELR21314.1 - 0.0054 16.3 8.4 0.0077 15.7 8.4 1.2 1 0 0 1 1 1 1 LRRFIP family Golgin_A5 PF09787.9 ELR21314.1 - 0.029 13.8 7.5 0.042 13.3 7.5 1.2 1 0 0 1 1 1 0 Golgin subfamily A member 5 TMF_DNA_bd PF12329.8 ELR21314.1 - 0.069 13.2 5.1 0.12 12.4 5.1 1.3 1 0 0 1 1 1 0 TATA element modulatory factor 1 DNA binding Atg14 PF10186.9 ELR21314.1 - 0.1 11.6 9.4 0.17 11.0 9.4 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 TMEM192 PF14802.6 ELR21314.1 - 0.12 11.5 0.2 0.2 10.7 0.2 1.3 1 0 0 1 1 1 0 TMEM192 family CCDC24 PF15669.5 ELR21314.1 - 0.23 11.3 8.2 0.36 10.7 8.2 1.2 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 24 family PAP1 PF08601.10 ELR21314.1 - 0.28 10.9 7.2 0.4 10.4 7.2 1.1 1 0 0 1 1 1 0 Transcription factor PAP1 Spc7 PF08317.11 ELR21314.1 - 0.28 10.0 6.1 0.39 9.5 6.1 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein LCD1 PF09798.9 ELR21314.1 - 0.29 9.6 2.2 0.4 9.1 2.2 1.1 1 0 0 1 1 1 0 DNA damage checkpoint protein DUF4718 PF15842.5 ELR21314.1 - 0.29 10.9 4.9 0.46 10.2 4.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4718) Rrn6 PF10214.9 ELR21314.1 - 0.61 8.5 11.8 0.84 8.1 11.8 1.1 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor UPF0242 PF06785.11 ELR21314.1 - 0.87 9.7 6.7 1.4 9.0 6.7 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus CENP-H PF05837.12 ELR21314.1 - 1.7 9.1 9.3 2.7 8.4 9.3 1.2 1 0 0 1 1 1 0 Centromere protein H (CENP-H) Plasmodium_Vir PF05795.11 ELR21314.1 - 3.7 6.9 4.4 5.3 6.4 4.4 1.1 1 0 0 1 1 1 0 Plasmodium vivax Vir protein Herpes_pp85 PF04637.12 ELR21314.1 - 5.5 5.3 8.6 7 4.9 8.6 1.1 1 0 0 1 1 1 0 Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25) GREB1 PF15782.5 ELR21314.1 - 8 3.4 9.1 11 3.0 9.1 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer PAS_9 PF13426.7 ELR21315.1 - 0.00063 20.0 0.0 0.0019 18.4 0.0 1.8 2 0 0 2 2 2 1 PAS domain PAS PF00989.25 ELR21315.1 - 0.0054 16.7 0.0 0.015 15.3 0.0 1.6 1 0 0 1 1 1 1 PAS fold TolA_bind_tri PF16331.5 ELR21315.1 - 0.011 15.8 0.6 0.023 14.7 0.6 1.4 1 0 0 1 1 1 0 TolA binding protein trimerisation PAS_8 PF13188.7 ELR21315.1 - 0.021 14.8 0.0 0.083 12.9 0.0 1.9 2 0 0 2 2 2 0 PAS domain TetR_C_14 PF17754.1 ELR21315.1 - 0.048 13.6 0.1 0.12 12.4 0.1 1.6 1 0 0 1 1 1 0 MftR C-terminal domain KIAA1430 PF13879.6 ELR21315.1 - 0.1 13.4 0.4 0.1 13.4 0.4 2.6 3 0 0 3 3 3 0 KIAA1430 homologue Leu_zip PF15294.6 ELR21315.1 - 0.17 11.4 0.2 0.28 10.7 0.2 1.2 1 0 0 1 1 1 0 Leucine zipper HALZ PF02183.18 ELR21315.1 - 0.2 11.9 0.0 0.37 11.1 0.0 1.3 1 0 0 1 1 1 0 Homeobox associated leucine zipper MEKHLA PF08670.11 ELR21316.1 - 0.0032 17.4 0.0 0.01 15.7 0.0 1.7 2 0 0 2 2 2 1 MEKHLA domain PAS_9 PF13426.7 ELR21316.1 - 0.0053 17.0 0.0 0.011 15.9 0.0 1.5 1 0 0 1 1 1 1 PAS domain PAS PF00989.25 ELR21316.1 - 0.012 15.5 0.0 0.026 14.5 0.0 1.5 1 1 0 1 1 1 0 PAS fold PAS_4 PF08448.10 ELR21316.1 - 0.014 15.6 1.0 0.18 12.1 0.0 2.9 2 2 1 3 3 3 0 PAS fold PAS_8 PF13188.7 ELR21316.1 - 0.016 15.2 0.0 0.036 14.1 0.0 1.6 1 0 0 1 1 1 0 PAS domain TMF_DNA_bd PF12329.8 ELR21316.1 - 0.14 12.2 0.1 0.22 11.5 0.1 1.3 1 0 0 1 1 1 0 TATA element modulatory factor 1 DNA binding Dicty_REP PF05086.12 ELR21316.1 - 1.4 6.8 1.8 1.8 6.5 1.8 1.0 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein PAS PF00989.25 ELR21317.1 - 0.00034 20.6 0.0 0.0014 18.6 0.0 1.9 2 0 0 2 2 2 1 PAS fold MEKHLA PF08670.11 ELR21317.1 - 0.00041 20.3 0.0 0.00093 19.1 0.0 1.5 1 0 0 1 1 1 1 MEKHLA domain PAS_8 PF13188.7 ELR21317.1 - 0.0031 17.5 0.0 0.0089 16.0 0.0 1.8 2 0 0 2 2 2 1 PAS domain PAS_9 PF13426.7 ELR21317.1 - 0.013 15.8 0.0 0.042 14.1 0.0 1.8 2 0 0 2 2 2 0 PAS domain TolA_bind_tri PF16331.5 ELR21317.1 - 0.17 12.0 0.0 0.29 11.2 0.0 1.4 1 0 0 1 1 1 0 TolA binding protein trimerisation PAS_9 PF13426.7 ELR21318.1 - 1e-05 25.7 0.0 1.6e-05 25.1 0.0 1.3 1 0 0 1 1 1 1 PAS domain PAS_8 PF13188.7 ELR21318.1 - 0.011 15.7 0.0 0.027 14.5 0.0 1.6 1 0 0 1 1 1 0 PAS domain PAS PF00989.25 ELR21318.1 - 0.033 14.2 0.0 0.13 12.3 0.0 1.9 1 1 0 1 1 1 0 PAS fold SR-25 PF10500.9 ELR21318.1 - 1 8.9 6.1 1.5 8.4 6.1 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein IMUP PF15761.5 ELR21318.1 - 1.4 9.6 6.4 2.5 8.9 6.4 1.4 1 0 0 1 1 1 0 Immortalisation up-regulated protein Aldo_ket_red PF00248.21 ELR21319.1 - 3.3e-68 230.1 0.0 3.8e-68 229.8 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family PAS_9 PF13426.7 ELR21320.1 - 0.00025 21.3 0.0 0.0021 18.3 0.0 2.2 2 0 0 2 2 2 1 PAS domain PAS PF00989.25 ELR21320.1 - 0.00044 20.2 0.0 0.0011 18.9 0.0 1.7 1 0 0 1 1 1 1 PAS fold PAS_8 PF13188.7 ELR21320.1 - 0.0038 17.2 0.0 0.011 15.8 0.0 1.7 1 0 0 1 1 1 1 PAS domain CitMHS_2 PF16980.5 ELR21320.1 - 0.0063 15.2 0.0 0.0077 14.9 0.0 1.2 1 0 0 1 1 1 1 Putative citrate transport PAS_3 PF08447.12 ELR21320.1 - 0.062 13.6 0.0 0.13 12.5 0.0 1.5 1 0 0 1 1 1 0 PAS fold NRBF2 PF08961.10 ELR21320.1 - 0.13 11.9 0.3 0.27 10.8 0.3 1.5 1 0 0 1 1 1 0 Nuclear receptor-binding factor 2, autophagy regulator PUL PF08324.11 ELR21321.1 - 2.3e-30 105.8 0.0 2.9e-30 105.4 0.0 1.1 1 0 0 1 1 1 1 PUL domain Thioredoxin PF00085.20 ELR21321.1 - 2.9e-22 78.6 0.0 5.1e-22 77.8 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_7 PF13899.6 ELR21321.1 - 0.0017 18.5 0.0 0.0039 17.3 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin-like Thioredoxin_2 PF13098.6 ELR21321.1 - 0.0042 17.5 0.0 0.019 15.4 0.0 1.9 1 1 0 1 1 1 1 Thioredoxin-like domain OST3_OST6 PF04756.13 ELR21321.1 - 0.0051 16.2 0.0 0.007 15.7 0.0 1.2 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family Thioredoxin_8 PF13905.6 ELR21321.1 - 0.0073 16.6 0.0 0.013 15.8 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin-like T4_deiodinase PF00837.17 ELR21321.1 - 0.016 14.5 0.0 0.039 13.2 0.0 1.6 2 0 0 2 2 2 0 Iodothyronine deiodinase Redoxin PF08534.10 ELR21321.1 - 0.076 12.7 0.0 0.16 11.7 0.0 1.5 1 0 0 1 1 1 0 Redoxin AhpC-TSA PF00578.21 ELR21321.1 - 0.17 11.8 0.0 0.3 11.0 0.0 1.3 1 0 0 1 1 1 0 AhpC/TSA family Thioredoxin_9 PF14595.6 ELR21321.1 - 0.25 11.1 0.0 0.38 10.5 0.0 1.3 1 0 0 1 1 1 0 Thioredoxin E2F_TDP PF02319.20 ELR21322.1 - 0.026 14.6 0.1 0.052 13.6 0.1 1.5 1 0 0 1 1 1 0 E2F/DP family winged-helix DNA-binding domain ATG101 PF07855.12 ELR21323.1 - 0.11 12.5 0.1 0.18 11.7 0.1 1.3 1 0 0 1 1 1 0 Autophagy-related protein 101 Pneumo_att_G PF05539.11 ELR21323.1 - 0.2 11.2 11.8 0.27 10.8 11.8 1.1 1 0 0 1 1 1 0 Pneumovirinae attachment membrane glycoprotein G Cytochrom_B558a PF05038.13 ELR21323.1 - 1 8.9 4.5 2.1 7.9 4.5 1.5 1 0 0 1 1 1 0 Cytochrome Cytochrome b558 alpha-subunit SRP-alpha_N PF04086.13 ELR21323.1 - 1.9 8.4 7.8 2.6 7.9 7.8 1.2 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal DUF4551 PF15087.6 ELR21323.1 - 3.4 6.4 8.2 4.4 6.0 8.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) SAM_1 PF00536.30 ELR21324.1 - 4.6e-29 100.6 0.1 2.2e-08 34.4 0.0 5.3 5 0 0 5 5 5 5 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 ELR21324.1 - 9.4e-26 89.7 0.0 1.4e-10 41.1 0.0 5.3 5 0 0 5 5 5 5 SAM domain (Sterile alpha motif) RRM_1 PF00076.22 ELR21326.1 - 3e-31 107.1 0.1 7.3e-14 51.3 0.1 3.3 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Pro_Al_protease PF02983.14 ELR21326.1 - 0.15 12.1 4.8 1.6 8.9 0.9 2.8 2 0 0 2 2 2 0 Alpha-lytic protease prodomain zf-RING_4 PF14570.6 ELR21327.1 - 7.5e-19 67.3 7.5 1.1e-18 66.8 7.5 1.2 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain RRM_1 PF00076.22 ELR21327.1 - 2.2e-08 33.8 0.0 6.3e-08 32.3 0.0 1.8 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-C3HC4_3 PF13920.6 ELR21327.1 - 1.3e-05 25.0 4.4 2.1e-05 24.3 4.4 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Rtf2 PF04641.12 ELR21327.1 - 0.00026 20.5 4.9 0.00032 20.1 4.9 1.1 1 0 0 1 1 1 1 Rtf2 RING-finger Prok-RING_4 PF14447.6 ELR21327.1 - 0.0042 16.9 3.3 0.0075 16.1 3.3 1.3 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-UDP PF14569.6 ELR21327.1 - 0.015 15.4 2.5 0.023 14.8 2.5 1.3 1 0 0 1 1 1 0 Zinc-binding RING-finger Baculo_IE-1 PF05290.11 ELR21327.1 - 0.041 13.8 4.6 0.041 13.8 4.6 2.1 1 1 1 2 2 2 0 Baculovirus immediate-early protein (IE-0) zf-RING_2 PF13639.6 ELR21327.1 - 0.042 14.2 4.7 0.06 13.7 4.7 1.3 1 0 0 1 1 1 0 Ring finger domain zf-C3HC4 PF00097.25 ELR21327.1 - 0.043 13.7 4.4 0.08 12.8 4.4 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 ELR21327.1 - 0.063 13.1 4.9 0.093 12.6 4.9 1.3 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Nup35_RRM_2 PF14605.6 ELR21327.1 - 0.12 12.4 0.0 0.25 11.4 0.0 1.6 1 1 0 1 1 1 0 Nup53/35/40-type RNA recognition motif DUF5345 PF17280.2 ELR21327.1 - 0.24 11.4 1.5 0.4 10.7 1.5 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5345) Lyase_1 PF00206.20 ELR21329.1 - 8.6e-20 71.3 0.0 1.3e-19 70.7 0.0 1.3 1 0 0 1 1 1 1 Lyase ADSL_C PF10397.9 ELR21329.1 - 7.9e-19 68.0 0.4 2.6e-18 66.3 0.1 2.1 2 0 0 2 2 2 1 Adenylosuccinate lyase C-terminus Talin_middle PF09141.10 ELR21329.1 - 0.05 13.6 0.2 0.62 10.1 0.1 2.4 2 0 0 2 2 2 0 Talin, middle domain Adenylsucc_synt PF00709.21 ELR21330.1 - 1.7e-171 570.8 0.0 2.1e-171 570.5 0.0 1.1 1 0 0 1 1 1 1 Adenylosuccinate synthetase Med6 PF04934.14 ELR21331.1 - 9.1e-32 109.7 0.0 1.3e-31 109.2 0.0 1.2 1 0 0 1 1 1 1 MED6 mediator sub complex component RNA_pol_Rpb8 PF03870.15 ELR21331.1 - 0.17 12.1 0.0 0.29 11.3 0.0 1.4 1 0 0 1 1 1 0 RNA polymerase Rpb8 NUC153 PF08159.12 ELR21332.1 - 8.1e-10 38.3 5.6 4.3e-05 23.2 0.2 2.8 2 0 0 2 2 2 2 NUC153 domain CPSase_L_D2 PF02786.17 ELR21333.1 - 9.2e-113 374.9 0.0 2e-79 266.0 0.0 2.3 2 0 0 2 2 2 2 Carbamoyl-phosphate synthase L chain, ATP binding domain CPSase_sm_chain PF00988.22 ELR21333.1 - 1.2e-50 170.6 0.0 3.6e-50 169.1 0.0 1.9 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase small chain, CPSase domain GATase PF00117.28 ELR21333.1 - 2.6e-43 148.0 0.0 5.9e-43 146.9 0.0 1.6 1 0 0 1 1 1 1 Glutamine amidotransferase class-I CPSase_L_D3 PF02787.19 ELR21333.1 - 7.8e-40 136.0 0.0 1.6e-39 135.0 0.0 1.6 1 0 0 1 1 1 1 Carbamoyl-phosphate synthetase large chain, oligomerisation domain ATP-grasp PF02222.22 ELR21333.1 - 2.9e-23 82.3 0.1 3.3e-11 43.0 0.0 2.4 2 0 0 2 2 2 2 ATP-grasp domain Dala_Dala_lig_C PF07478.13 ELR21333.1 - 2.7e-19 69.5 0.9 7.6e-10 38.7 0.1 2.4 2 0 0 2 2 2 2 D-ala D-ala ligase C-terminus ATPgrasp_Ter PF15632.6 ELR21333.1 - 1.6e-11 44.1 0.0 0.00013 21.7 0.0 2.6 2 0 0 2 2 2 2 ATP-grasp in the biosynthetic pathway with Ter operon Peptidase_C26 PF07722.13 ELR21333.1 - 1.8e-08 34.4 0.0 5.1e-06 26.4 0.0 2.5 1 1 0 1 1 1 1 Peptidase C26 ATP-grasp_3 PF02655.14 ELR21333.1 - 3.3e-07 30.5 0.7 0.006 16.6 0.0 2.5 2 0 0 2 2 2 2 ATP-grasp domain GARS_A PF01071.19 ELR21333.1 - 5.8e-05 22.9 0.1 0.0054 16.5 0.0 2.4 2 0 0 2 2 2 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain MGS PF02142.22 ELR21333.1 - 6e-05 23.2 0.0 0.00033 20.8 0.0 2.4 2 0 0 2 2 2 1 MGS-like domain DJ-1_PfpI PF01965.24 ELR21333.1 - 8.9e-05 22.4 0.2 0.083 12.7 0.0 3.6 4 0 0 4 4 4 1 DJ-1/PfpI family ATP-grasp_5 PF13549.6 ELR21333.1 - 0.0022 17.5 0.0 2.6 7.5 0.0 3.8 4 0 0 4 4 4 1 ATP-grasp domain RimK PF08443.11 ELR21333.1 - 0.031 13.9 0.1 2.2 7.8 0.0 2.8 2 1 0 2 2 2 0 RimK-like ATP-grasp domain Lyase_1 PF00206.20 ELR21334.1 - 6.7e-56 189.9 0.1 2.3e-55 188.2 0.0 1.8 2 0 0 2 2 2 1 Lyase ASL_C2 PF14698.6 ELR21334.1 - 6.3e-10 39.7 0.0 1.8e-09 38.2 0.0 1.9 1 0 0 1 1 1 1 Argininosuccinate lyase C-terminal Ank_4 PF13637.6 ELR21335.1 - 2.5e-19 69.4 0.4 1.5e-10 41.4 0.0 2.4 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 ELR21335.1 - 7e-18 64.5 3.2 1.1e-10 41.5 1.1 2.4 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 ELR21335.1 - 2.3e-15 56.9 1.6 4.1e-15 56.1 1.6 1.4 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.30 ELR21335.1 - 4.3e-14 52.2 5.0 3.2e-06 27.3 0.9 3.2 3 0 0 3 3 3 2 Ankyrin repeat Ank_3 PF13606.6 ELR21335.1 - 1.7e-13 49.4 0.2 8.8e-05 22.6 0.1 3.1 3 0 0 3 3 3 2 Ankyrin repeat TFIIS_M PF07500.14 ELR21336.1 - 3.3e-25 88.7 1.7 6.4e-25 87.8 1.7 1.5 1 0 0 1 1 1 1 Transcription factor S-II (TFIIS), central domain SPOC PF07744.13 ELR21336.1 - 8.2e-16 58.3 0.0 1.4e-15 57.5 0.0 1.4 1 0 0 1 1 1 1 SPOC domain PHD PF00628.29 ELR21336.1 - 2.2e-09 37.0 2.9 4.5e-09 36.1 2.9 1.5 1 0 0 1 1 1 1 PHD-finger zf-RING_2 PF13639.6 ELR21336.1 - 0.59 10.5 2.2 0.97 9.8 2.2 1.4 1 0 0 1 1 1 0 Ring finger domain Cyt-b5 PF00173.28 ELR21337.1 - 4.1e-17 62.1 0.0 5.2e-17 61.7 0.0 1.1 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain VIT1 PF01988.19 ELR21338.1 - 2.1e-16 60.4 0.3 3.2e-16 59.9 0.3 1.3 1 0 0 1 1 1 1 VIT family RLL PF10036.9 ELR21339.1 - 1.1e-58 199.1 0.0 1.3e-58 198.9 0.0 1.0 1 0 0 1 1 1 1 RNA transcription, translation and transport factor protein Uteroglobin PF01099.17 ELR21339.1 - 0.19 12.1 0.1 0.49 10.8 0.0 1.7 2 0 0 2 2 2 0 Uteroglobin family PUF PF00806.19 ELR21340.1 - 6.2e-68 220.8 15.7 3e-08 32.9 0.0 8.5 7 1 1 8 8 8 8 Pumilio-family RNA binding repeat BAF1_ABF1 PF04684.13 ELR21340.1 - 0.0018 17.4 1.9 0.0025 16.9 1.9 1.2 1 0 0 1 1 1 1 BAF1 / ABF1 chromatin reorganising factor HABP4_PAI-RBP1 PF04774.15 ELR21340.1 - 0.041 14.7 3.2 0.086 13.7 3.2 1.5 1 0 0 1 1 1 0 Hyaluronan / mRNA binding family sCache_2 PF17200.4 ELR21340.1 - 0.096 12.5 7.7 1.8 8.4 0.0 5.3 6 0 0 6 6 6 0 Single Cache domain 2 MIF4G PF02854.19 ELR21340.1 - 2.3 7.8 8.4 0.6 9.7 0.1 3.2 3 0 0 3 3 3 0 MIF4G domain MMR1 PF08505.10 ELR21340.1 - 2.8 8.2 8.0 4.7 7.4 8.0 1.3 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein CNH PF00780.22 ELR21341.1 - 7.9e-27 94.5 0.0 1.5e-26 93.6 0.0 1.5 1 0 0 1 1 1 1 CNH domain Vps39_2 PF10367.9 ELR21341.1 - 3e-20 72.7 0.0 1.2e-18 67.6 0.0 2.9 3 0 0 3 3 3 1 Vacuolar sorting protein 39 domain 2 Clathrin PF00637.20 ELR21341.1 - 7.7e-10 38.8 0.2 0.00011 22.1 0.0 2.8 2 1 0 2 2 2 2 Region in Clathrin and VPS Vps39_1 PF10366.9 ELR21341.1 - 9.9e-05 22.6 0.1 0.0027 18.0 0.0 3.1 3 1 0 3 3 3 1 Vacuolar sorting protein 39 domain 1 PQQ_3 PF13570.6 ELR21341.1 - 0.035 14.6 0.3 5.6 7.6 0.0 2.8 2 0 0 2 2 2 0 PQQ-like domain TPR_1 PF00515.28 ELR21341.1 - 0.13 12.2 3.0 15 5.6 0.0 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_12 PF13424.6 ELR21341.1 - 2.7 8.4 9.2 5.6 7.3 1.0 3.7 3 0 0 3 3 3 0 Tetratricopeptide repeat Glyco_trans_1_4 PF13692.6 ELR21342.1 - 2.6e-13 50.6 0.0 6.3e-13 49.3 0.0 1.6 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glycos_transf_1 PF00534.20 ELR21342.1 - 8.7e-10 38.4 0.0 2.4e-09 37.0 0.0 1.7 1 1 0 1 1 1 1 Glycosyl transferases group 1 Glycogen_syn PF05693.13 ELR21342.1 - 0.098 11.2 0.0 0.15 10.5 0.0 1.3 1 0 0 1 1 1 0 Glycogen synthase Glyco_trans_1_2 PF13524.6 ELR21342.1 - 0.11 12.9 0.0 4.1 7.9 0.0 3.0 2 0 0 2 2 2 0 Glycosyl transferases group 1 SR-25 PF10500.9 ELR21342.1 - 3.3 7.2 6.3 6.3 6.3 6.3 1.4 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein DUF4602 PF15375.6 ELR21343.1 - 2.2e-23 83.0 11.4 2.2e-23 83.0 11.4 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF4602) PWWP PF00855.17 ELR21344.1 - 0.0073 16.7 6.6 0.0073 16.7 6.6 3.9 2 2 0 2 2 2 1 PWWP domain Ku PF02735.16 ELR21345.1 - 5.3e-40 137.3 0.0 8.5e-40 136.6 0.0 1.3 1 0 0 1 1 1 1 Ku70/Ku80 beta-barrel domain Ku_N PF03731.15 ELR21345.1 - 1.3e-15 57.8 0.0 3.4e-14 53.1 0.0 2.9 1 1 0 1 1 1 1 Ku70/Ku80 N-terminal alpha/beta domain Ku_PK_bind PF08785.11 ELR21345.1 - 5.7e-14 52.3 1.8 1.2e-10 41.5 1.8 2.9 1 1 0 1 1 1 1 Ku C terminal domain like VWA_2 PF13519.6 ELR21345.1 - 0.0016 19.1 0.5 0.015 15.9 0.2 2.8 2 1 0 2 2 2 1 von Willebrand factor type A domain Ku_C PF03730.14 ELR21345.1 - 0.0016 19.1 0.4 0.0016 19.1 0.4 3.4 4 0 0 4 4 4 1 Ku70/Ku80 C-terminal arm FTCD_C PF04961.12 ELR21345.1 - 0.053 13.3 0.3 0.053 13.3 0.3 2.3 2 0 0 2 2 2 0 Formiminotransferase-cyclodeaminase Mpv17_PMP22 PF04117.12 ELR21346.1 - 2.2e-21 75.8 3.9 4.1e-21 75.0 3.9 1.5 1 0 0 1 1 1 1 Mpv17 / PMP22 family DEAD PF00270.29 ELR21347.1 - 7.3e-27 94.3 1.3 5.9e-16 58.7 0.0 3.1 2 1 1 3 3 3 2 DEAD/DEAH box helicase Helicase_C PF00271.31 ELR21347.1 - 3.7e-24 85.2 0.0 3e-23 82.3 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 ELR21347.1 - 1.3e-06 28.5 0.5 0.00026 21.1 0.5 2.6 1 1 0 1 1 1 1 Domain of unknown function (DUF4217) ERCC3_RAD25_C PF16203.5 ELR21347.1 - 0.00033 19.9 0.0 0.00058 19.2 0.0 1.3 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase Helicase_C_2 PF13307.6 ELR21347.1 - 0.098 12.8 0.0 0.22 11.7 0.0 1.5 1 0 0 1 1 1 0 Helicase C-terminal domain SURF2 PF05477.11 ELR21348.1 - 0.089 12.5 13.8 0.14 11.9 13.8 1.2 1 0 0 1 1 1 0 Surfeit locus protein 2 (SURF2) GRP PF07172.11 ELR21348.1 - 0.98 10.2 6.4 1.9 9.2 6.1 1.7 1 1 0 1 1 1 0 Glycine rich protein family HATPase_c PF02518.26 ELR21349.1 - 4.5e-20 72.2 0.0 1.2e-19 70.9 0.0 1.7 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 ELR21349.1 - 7.7e-19 67.9 0.0 1.5e-18 67.0 0.0 1.5 1 0 0 1 1 1 1 Response regulator receiver domain HisKA PF00512.25 ELR21349.1 - 1.7e-08 34.4 1.4 4.3e-08 33.1 0.0 2.4 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain GAF_2 PF13185.6 ELR21349.1 - 0.0047 17.2 0.1 0.023 15.0 0.0 2.3 2 0 0 2 2 2 1 GAF domain HATPase_c_2 PF13581.6 ELR21349.1 - 0.096 12.7 0.0 0.22 11.5 0.0 1.6 1 0 0 1 1 1 0 Histidine kinase-like ATPase domain MatE PF01554.18 ELR21350.1 - 5.6e-52 175.7 29.8 2e-24 86.1 8.5 3.4 2 1 1 3 3 3 3 MatE RFX_DNA_binding PF02257.15 ELR21351.1 - 1.1e-14 54.7 0.1 2.2e-14 53.8 0.1 1.4 1 0 0 1 1 1 1 RFX DNA-binding domain SUIM_assoc PF16619.5 ELR21351.1 - 0.0021 18.1 18.1 0.0047 17.0 5.5 4.5 4 1 0 4 4 4 2 Unstructured region C-term to UIM in Ataxin3 TFIIA PF03153.13 ELR21351.1 - 0.087 12.8 33.0 0.076 13.0 15.5 2.3 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit PBP1_TM PF14812.6 ELR21351.1 - 0.34 11.3 5.0 12 6.4 5.7 2.5 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal PPP4R2 PF09184.11 ELR21351.1 - 0.72 9.4 9.5 1.2 8.6 9.5 1.2 1 0 0 1 1 1 0 PPP4R2 Orf78 PF06024.12 ELR21351.1 - 0.94 9.8 0.0 0.94 9.8 0.0 2.7 4 0 0 4 4 4 0 Orf78 (ac78) RXT2_N PF08595.11 ELR21351.1 - 8.6 6.4 13.3 0.34 10.9 6.0 2.2 2 0 0 2 2 2 0 RXT2-like, N-terminal Ank_2 PF12796.7 ELR21352.1 - 4.3e-38 129.8 2.4 2.9e-10 40.6 0.0 5.3 3 2 3 6 6 6 6 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ELR21352.1 - 1.1e-33 115.2 0.1 1.3e-08 35.2 0.0 6.7 4 2 2 7 7 7 5 Ankyrin repeats (many copies) Ank PF00023.30 ELR21352.1 - 4.4e-32 109.1 0.5 0.0006 20.2 0.0 8.2 8 0 0 8 8 8 5 Ankyrin repeat Ank_3 PF13606.6 ELR21352.1 - 1.4e-27 92.7 0.0 0.015 15.8 0.0 8.3 8 0 0 8 8 8 5 Ankyrin repeat Ank_5 PF13857.6 ELR21352.1 - 1.8e-27 95.0 7.2 8.4e-06 26.0 0.1 7.0 4 3 3 8 8 8 5 Ankyrin repeats (many copies) RR_TM4-6 PF06459.12 ELR21352.1 - 0.025 14.4 3.0 0.045 13.6 3.0 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Nucleo_P87 PF07267.11 ELR21352.1 - 0.094 11.6 8.1 0.14 11.0 8.1 1.2 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 DUF4778 PF16008.5 ELR21352.1 - 0.12 12.5 1.9 0.22 11.5 1.9 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4778) Myc_N PF01056.18 ELR21352.1 - 0.14 12.0 2.3 0.26 11.1 2.3 1.5 1 0 0 1 1 1 0 Myc amino-terminal region DUF2207 PF09972.9 ELR21352.1 - 0.45 9.2 3.7 0.74 8.5 3.7 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) PBP1_TM PF14812.6 ELR21352.1 - 0.56 10.6 15.9 1.7 9.1 15.9 1.9 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal PAS_7 PF12860.7 ELR21352.1 - 0.78 9.9 2.7 0.91 9.7 0.9 2.0 1 1 1 2 2 2 0 PAS fold Phostensin PF13914.6 ELR21352.1 - 1.3 9.7 3.4 2.7 8.6 1.5 2.5 3 0 0 3 3 2 0 Phostensin PP1-binding and SH3-binding region Phage_holin_3_6 PF07332.11 ELR21352.1 - 2.1 8.4 7.9 5.2 7.2 7.9 1.6 1 0 0 1 1 1 0 Putative Actinobacterial Holin-X, holin superfamily III FAM176 PF14851.6 ELR21352.1 - 3.5 7.3 9.2 8 6.1 9.2 1.6 1 0 0 1 1 1 0 FAM176 family DUF4834 PF16118.5 ELR21352.1 - 7.7 7.6 11.2 3.6 8.6 0.2 3.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) DUF1604 PF07713.13 ELR21353.1 - 6.7e-36 122.0 3.3 6.7e-36 122.0 3.3 3.7 3 1 0 3 3 3 1 Protein of unknown function (DUF1604) G-patch PF01585.23 ELR21353.1 - 1.1e-06 28.4 1.0 3.8e-06 26.7 1.0 1.9 1 0 0 1 1 1 1 G-patch domain DUF3446 PF11928.8 ELR21353.1 - 1.6 9.1 8.2 0.12 12.7 1.0 2.5 2 0 0 2 2 2 0 Early growth response N-terminal domain G-patch_2 PF12656.7 ELR21353.1 - 3.3 7.9 8.5 0.21 11.7 0.2 3.3 3 0 0 3 3 3 0 G-patch domain zf-UBR PF02207.20 ELR21354.1 - 2.1e-10 40.6 10.5 2.1e-10 40.6 10.5 3.0 2 1 0 2 2 2 1 Putative zinc finger in N-recognin (UBR box) RR_TM4-6 PF06459.12 ELR21354.1 - 3.3 7.5 10.7 3.3 7.5 4.7 2.5 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 RRM_1 PF00076.22 ELR21357.1 - 2.8e-17 62.3 0.0 4.5e-17 61.6 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 ELR21357.1 - 0.035 14.2 0.0 0.2 11.8 0.0 2.0 1 1 0 1 1 1 0 RNA recognition motif FapA PF03961.13 ELR21357.1 - 0.047 12.3 0.1 0.058 12.0 0.1 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A Nup35_RRM_2 PF14605.6 ELR21357.1 - 0.066 13.2 0.0 0.11 12.5 0.0 1.4 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif GPS2_interact PF15784.5 ELR21357.1 - 0.073 13.5 1.6 0.12 12.8 1.6 1.3 1 0 0 1 1 1 0 G-protein pathway suppressor 2-interacting domain DUF4226 PF10774.9 ELR21357.1 - 0.12 12.7 1.3 0.2 11.9 1.3 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4226) DUF1366 PF07104.11 ELR21357.1 - 0.17 11.6 3.4 0.5 10.1 2.4 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF1366) GRP PF07172.11 ELR21357.1 - 0.24 12.1 13.4 0.075 13.7 9.5 2.0 2 0 0 2 2 2 0 Glycine rich protein family Aldolase_II PF00596.21 ELR21358.1 - 4.1e-42 144.2 0.2 4.1e-42 144.2 0.2 1.4 1 1 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain Myb_DNA-binding PF00249.31 ELR21360.1 - 2.3e-53 178.1 15.2 1.9e-17 63.2 1.6 3.4 3 0 0 3 3 3 3 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 ELR21360.1 - 9.8e-41 137.8 12.6 1.2e-19 70.3 1.3 3.9 2 1 2 4 4 4 3 Myb-like DNA-binding domain Myb_DNA-bind_7 PF15963.5 ELR21360.1 - 1.3e-08 34.6 1.4 0.00047 20.0 0.1 3.5 1 1 2 3 3 3 2 Myb DNA-binding like SLIDE PF09111.10 ELR21360.1 - 2.5e-07 30.7 0.1 0.11 12.6 0.0 3.3 1 1 2 3 3 3 3 SLIDE SANT_DAMP1_like PF16282.5 ELR21360.1 - 9.1e-05 22.6 0.9 1.7 8.9 0.0 3.3 2 1 1 3 3 3 2 SANT/Myb-like domain of DAMP1 Rap1_C PF11626.8 ELR21360.1 - 0.0089 16.1 7.6 2.6 8.2 0.3 3.3 1 1 2 3 3 3 2 TRF2-interacting telomeric protein/Rap1 - C terminal domain DUF1348 PF07080.11 ELR21360.1 - 0.12 12.4 2.4 0.18 11.8 0.4 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1348) SR-25 PF10500.9 ELR21360.1 - 0.33 10.5 15.1 0.13 11.8 0.3 2.7 3 0 0 3 3 3 0 Nuclear RNA-splicing-associated protein polyprenyl_synt PF00348.17 ELR21361.1 - 9e-62 208.4 0.0 8e-43 146.3 0.0 2.1 1 1 1 2 2 2 2 Polyprenyl synthetase Rhodanese PF00581.20 ELR21362.1 - 2.1e-11 44.3 0.0 4.7e-11 43.2 0.0 1.5 1 0 0 1 1 1 1 Rhodanese-like domain EMP24_GP25L PF01105.24 ELR21363.1 - 1.7 8.5 6.6 3.5 7.5 1.5 2.9 2 0 0 2 2 2 0 emp24/gp25L/p24 family/GOLD SHE3 PF17078.5 ELR21363.1 - 2.7 7.6 34.9 0.32 10.7 10.2 2.7 2 0 0 2 2 2 0 SWI5-dependent HO expression protein 3 WD40 PF00400.32 ELR21364.1 - 3.6e-25 87.7 15.7 0.00029 21.6 1.0 6.8 6 1 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ELR21364.1 - 4.5e-06 26.9 6.1 0.056 13.8 0.1 3.8 2 2 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ELR21364.1 - 0.0071 15.3 1.6 4.9 6.0 0.6 3.9 3 1 1 4 4 4 1 WD40 region of Ge1, enhancer of mRNA-decapping protein PhoD PF09423.10 ELR21365.1 - 4.6e-19 68.7 0.0 9.4e-19 67.6 0.0 1.5 1 1 0 1 1 1 1 PhoD-like phosphatase FG-GAP_2 PF14312.6 ELR21365.1 - 0.15 12.3 0.3 19 5.6 0.1 2.5 2 0 0 2 2 2 0 FG-GAP repeat ABC1 PF03109.16 ELR21367.1 - 8.4e-34 116.3 0.2 1.8e-33 115.2 0.2 1.6 1 0 0 1 1 1 1 ABC1 family Pkinase PF00069.25 ELR21367.1 - 0.00015 21.3 0.2 0.00021 20.8 0.2 1.3 1 0 0 1 1 1 1 Protein kinase domain WaaY PF06176.11 ELR21367.1 - 0.0068 16.1 0.1 0.011 15.4 0.1 1.2 1 0 0 1 1 1 1 Lipopolysaccharide core biosynthesis protein (WaaY) APH PF01636.23 ELR21367.1 - 0.019 14.9 0.8 0.85 9.5 0.3 2.7 2 1 1 3 3 3 0 Phosphotransferase enzyme family RWP-RK PF02042.15 ELR21368.1 - 6.2e-05 22.9 0.2 0.0001 22.2 0.2 1.3 1 0 0 1 1 1 1 RWP-RK domain HTH_8 PF02954.19 ELR21368.1 - 0.00029 20.6 0.0 0.00057 19.6 0.0 1.5 1 0 0 1 1 1 1 Bacterial regulatory protein, Fis family HTH_3 PF01381.22 ELR21368.1 - 0.0024 17.9 0.0 0.0048 16.9 0.0 1.5 1 0 0 1 1 1 1 Helix-turn-helix HTH_psq PF05225.16 ELR21368.1 - 0.0042 16.8 0.0 0.0082 15.9 0.0 1.4 1 0 0 1 1 1 1 helix-turn-helix, Psq domain HTH_23 PF13384.6 ELR21368.1 - 0.0044 16.8 0.0 0.0089 15.8 0.0 1.5 1 0 0 1 1 1 1 Homeodomain-like domain HTH_28 PF13518.6 ELR21368.1 - 0.034 14.3 0.0 0.19 11.9 0.0 2.1 2 0 0 2 2 2 0 Helix-turn-helix domain HTH_24 PF13412.6 ELR21368.1 - 0.12 12.0 0.0 0.24 11.0 0.0 1.5 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding DTW PF03942.15 ELR21369.1 - 5.8e-15 55.5 0.0 1.3e-14 54.4 0.0 1.6 1 0 0 1 1 1 1 DTW domain Borrelia_P83 PF05262.11 ELR21369.1 - 0.02 13.4 15.0 0.027 13.0 15.0 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein DUF3090 PF11290.8 ELR21369.1 - 0.36 10.6 7.2 0.86 9.4 7.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3090) SLC12 PF03522.15 ELR21369.1 - 0.5 9.3 5.3 0.79 8.7 5.3 1.3 1 0 0 1 1 1 0 Solute carrier family 12 CDC45 PF02724.14 ELR21369.1 - 4.6 5.4 19.5 6.9 4.8 19.5 1.3 1 0 0 1 1 1 0 CDC45-like protein Mpp10 PF04006.12 ELR21370.1 - 3.6e-107 359.3 72.5 1.5e-80 271.4 14.7 2.9 1 1 1 2 2 2 2 Mpp10 protein Kelch_4 PF13418.6 ELR21371.1 - 1.1e-28 98.9 0.4 2.4e-06 27.4 0.0 6.1 6 0 0 6 6 6 5 Galactose oxidase, central domain Kelch_5 PF13854.6 ELR21371.1 - 3.3e-28 97.2 1.7 3.3e-06 26.9 0.0 6.3 6 0 0 6 6 6 4 Kelch motif Kelch_1 PF01344.25 ELR21371.1 - 3.3e-26 90.6 0.5 4.2e-05 23.0 0.0 6.9 7 0 0 7 7 7 5 Kelch motif Kelch_6 PF13964.6 ELR21371.1 - 3.1e-23 81.2 0.0 0.00014 22.0 0.0 6.6 6 0 0 6 6 6 5 Kelch motif Kelch_3 PF13415.6 ELR21371.1 - 4.5e-21 74.6 2.6 0.0014 18.9 0.0 7.0 6 0 0 6 6 6 5 Galactose oxidase, central domain Kelch_2 PF07646.15 ELR21371.1 - 3e-19 68.1 3.9 0.00013 21.8 0.1 6.0 5 0 0 5 5 5 5 Kelch motif PH PF00169.29 ELR21371.1 - 2.3e-09 37.7 0.0 7.6e-09 36.0 0.0 2.0 1 0 0 1 1 1 1 PH domain GREB1 PF15782.5 ELR21372.1 - 0.047 10.8 9.7 0.063 10.4 9.7 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer YL1 PF05764.13 ELR21372.1 - 0.86 9.7 24.3 1.5 8.9 24.3 1.4 1 0 0 1 1 1 0 YL1 nuclear protein Dicty_REP PF05086.12 ELR21372.1 - 4 5.3 9.5 7.7 4.4 9.5 1.4 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein DUF4551 PF15087.6 ELR21372.1 - 4.8 5.9 11.8 6.8 5.4 11.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) Macoilin PF09726.9 ELR21372.1 - 6.8 5.1 12.8 10 4.5 12.8 1.2 1 0 0 1 1 1 0 Macoilin family PALP PF00291.25 ELR21373.1 - 2.9e-13 49.9 0.0 1.1e-07 31.6 0.0 2.1 1 1 1 2 2 2 2 Pyridoxal-phosphate dependent enzyme PALP PF00291.25 ELR21374.1 - 2e-13 50.4 0.0 3.2e-13 49.7 0.0 1.3 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme SR-25 PF10500.9 ELR21374.1 - 0.07 12.7 5.0 0.095 12.3 5.0 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein DUF3446 PF11928.8 ELR21375.1 - 0.0044 17.3 5.0 0.0073 16.6 5.0 1.3 1 0 0 1 1 1 1 Early growth response N-terminal domain DUF1356 PF07092.12 ELR21376.1 - 1.3e-09 37.6 0.1 1.7e-09 37.3 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1356) LEA_2 PF03168.13 ELR21376.1 - 4.1e-05 24.0 0.0 6.6e-05 23.4 0.0 1.4 1 0 0 1 1 1 1 Late embryogenesis abundant protein Vac7 PF12751.7 ELR21376.1 - 0.0033 16.9 0.0 0.0064 16.0 0.0 1.4 1 1 0 1 1 1 1 Vacuolar segregation subunit 7 Keratin_2_head PF16208.5 ELR21376.1 - 1.7 8.8 19.2 2.6 8.2 19.2 1.2 1 0 0 1 1 1 0 Keratin type II head Homeodomain PF00046.29 ELR21377.1 - 1e-16 60.5 0.6 1e-16 60.5 0.6 2.4 2 0 0 2 2 2 1 Homeodomain Homeobox_KN PF05920.11 ELR21377.1 - 0.00019 21.2 0.0 0.00019 21.2 0.0 2.0 2 0 0 2 2 2 1 Homeobox KN domain Viral_P18 PF04521.13 ELR21377.1 - 0.076 12.8 0.5 0.14 11.9 0.5 1.4 1 0 0 1 1 1 0 ssRNA positive strand viral 18kD cysteine rich protein Attacin_N PF03768.15 ELR21377.1 - 0.085 13.0 1.0 2.2 8.5 0.0 2.9 2 0 0 2 2 2 0 Attacin, N-terminal region TFIIA PF03153.13 ELR21377.1 - 0.21 11.6 20.6 0.3 11.0 20.6 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF755 PF05501.11 ELR21377.1 - 8.9 6.6 34.3 1.9 8.8 13.6 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF755) PRA1 PF03208.19 ELR21378.1 - 6.1e-25 87.5 3.8 7.7e-25 87.2 3.8 1.1 1 0 0 1 1 1 1 PRA1 family protein PNP_UDP_1 PF01048.20 ELR21379.1 - 9.6e-27 93.7 0.1 1.3e-26 93.3 0.1 1.1 1 0 0 1 1 1 1 Phosphorylase superfamily dNK PF01712.19 ELR21380.1 - 6.9e-41 140.4 3.1 8.3e-41 140.1 3.1 1.0 1 0 0 1 1 1 1 Deoxynucleoside kinase Thymidylate_kin PF02223.17 ELR21380.1 - 0.00059 19.6 0.1 0.0012 18.6 0.1 1.5 1 1 0 1 1 1 1 Thymidylate kinase AAA_18 PF13238.6 ELR21380.1 - 0.0065 17.0 0.2 0.043 14.4 0.0 2.0 2 0 0 2 2 2 1 AAA domain Herpes_TK PF00693.18 ELR21380.1 - 0.021 14.1 0.0 0.025 13.8 0.0 1.2 1 0 0 1 1 1 0 Thymidine kinase from herpesvirus SKI PF01202.22 ELR21380.1 - 0.1 12.7 0.1 0.26 11.4 0.1 1.8 1 1 1 2 2 2 0 Shikimate kinase p450 PF00067.22 ELR21382.1 - 1.1e-88 298.1 0.0 1.5e-88 297.6 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 GON PF08685.11 ELR21382.1 - 0.0058 16.5 0.0 0.021 14.7 0.0 1.8 1 1 0 1 1 1 1 GON domain MFS_1 PF07690.16 ELR21383.1 - 3.4e-32 111.7 36.5 7.6e-32 110.6 35.8 1.7 2 0 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 ELR21383.1 - 1.2e-05 24.4 13.9 1.2e-05 24.4 13.9 2.6 2 2 0 2 2 2 1 Sugar (and other) transporter OATP PF03137.20 ELR21383.1 - 1.2 7.4 6.9 3.5 5.8 2.5 2.5 2 0 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family Redoxin PF08534.10 ELR21384.1 - 2.2e-11 43.7 0.0 2.3e-11 43.6 0.0 1.1 1 0 0 1 1 1 1 Redoxin MEA1 PF06910.11 ELR21385.1 - 3.7e-05 24.4 0.0 6.4e-05 23.6 0.0 1.4 1 0 0 1 1 1 1 Male enhanced antigen 1 (MEA1) CDKN3 PF05706.12 ELR21385.1 - 5.3e-05 22.9 0.0 8.1e-05 22.3 0.0 1.2 1 0 0 1 1 1 1 Cyclin-dependent kinase inhibitor 3 (CDKN3) Y_phosphatase3 PF13350.6 ELR21385.1 - 0.0026 17.8 0.3 0.0066 16.4 0.0 1.7 2 0 0 2 2 2 1 Tyrosine phosphatase family DSPc PF00782.20 ELR21385.1 - 0.014 15.2 0.0 0.025 14.4 0.0 1.4 1 0 0 1 1 1 0 Dual specificity phosphatase, catalytic domain rRNA_methylase PF06962.12 ELR21385.1 - 0.032 14.2 0.0 0.29 11.1 0.0 2.0 2 0 0 2 2 2 0 Putative rRNA methylase PTPlike_phytase PF14566.6 ELR21385.1 - 0.089 12.9 0.0 0.42 10.7 0.0 1.9 2 0 0 2 2 2 0 Inositol hexakisphosphate NapD PF03927.13 ELR21385.1 - 0.1 12.6 0.2 0.24 11.5 0.2 1.5 1 0 0 1 1 1 0 NapD protein Y_phosphatase PF00102.27 ELR21385.1 - 0.21 11.1 0.0 0.51 9.9 0.0 1.4 1 1 0 1 1 1 0 Protein-tyrosine phosphatase BRD4_CDT PF17105.5 ELR21385.1 - 0.21 11.2 2.7 0.41 10.3 2.7 1.4 1 0 0 1 1 1 0 C-terminal domain of bromodomain protein 4 DUF3138 PF11336.8 ELR21385.1 - 0.26 9.8 3.3 0.37 9.4 3.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) Usp PF00582.26 ELR21386.1 - 1.6e-08 35.2 2.3 1.6e-07 32.0 0.0 2.8 2 2 0 2 2 2 1 Universal stress protein family Cwf_Cwc_15 PF04889.12 ELR21386.1 - 0.15 11.8 3.6 0.23 11.2 3.6 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein DUF465 PF04325.13 ELR21386.1 - 6.1 7.0 8.9 9.6 6.3 0.6 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF465) Thioredoxin PF00085.20 ELR21387.1 - 1.3e-05 25.1 0.0 1.7e-05 24.7 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin OST3_OST6 PF04756.13 ELR21387.1 - 0.0041 16.5 0.2 1.1 8.6 0.0 2.1 1 1 1 2 2 2 2 OST3 / OST6 family, transporter family DUF836 PF05768.14 ELR21387.1 - 0.045 14.2 0.0 0.062 13.7 0.0 1.2 1 0 0 1 1 1 0 Glutaredoxin-like domain (DUF836) DUF3752 PF12572.8 ELR21388.1 - 6.2e-15 56.0 13.0 6.2e-15 56.0 13.0 2.1 1 1 0 2 2 2 1 Protein of unknown function (DUF3752) MBF1 PF08523.10 ELR21389.1 - 2.9e-10 40.4 6.0 2.9e-10 40.4 6.0 2.3 2 1 0 2 2 2 1 Multiprotein bridging factor 1 HTH_3 PF01381.22 ELR21389.1 - 1.5e-08 34.5 0.6 3.2e-08 33.5 0.6 1.6 1 0 0 1 1 1 1 Helix-turn-helix HTH_31 PF13560.6 ELR21389.1 - 2e-06 28.1 0.6 3.2e-06 27.4 0.6 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_25 PF13413.6 ELR21389.1 - 0.0016 18.3 0.7 0.0028 17.5 0.2 1.8 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_19 PF12844.7 ELR21389.1 - 0.0072 16.3 0.3 0.012 15.7 0.3 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_37 PF13744.6 ELR21389.1 - 0.008 16.1 0.2 0.012 15.5 0.2 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_38 PF13936.6 ELR21389.1 - 0.15 11.8 0.1 0.27 11.0 0.1 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain UBA_4 PF14555.6 ELR21390.1 - 3e-07 30.1 0.1 6.5e-07 29.1 0.1 1.5 1 0 0 1 1 1 1 UBA-like domain LysM PF01476.20 ELR21390.1 - 5e-07 29.7 0.0 8.4e-07 29.0 0.0 1.4 1 0 0 1 1 1 1 LysM domain BTK PF00779.19 ELR21390.1 - 0.0011 18.7 1.5 0.0011 18.7 1.5 2.8 3 0 0 3 3 3 1 BTK motif CHORD PF04968.12 ELR21390.1 - 0.013 16.2 3.9 0.07 13.9 3.9 2.2 1 1 0 1 1 1 0 CHORD HIPIP PF01355.17 ELR21390.1 - 0.098 13.0 4.9 0.41 11.0 1.9 2.5 2 0 0 2 2 2 0 High potential iron-sulfur protein zinc_ribbon_5 PF13719.6 ELR21390.1 - 3.1 7.6 5.6 0.24 11.2 0.4 1.9 2 0 0 2 2 2 0 zinc-ribbon domain PhyH PF05721.13 ELR21391.1 - 3.7e-19 69.8 0.0 7.1e-19 68.9 0.0 1.5 1 1 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) DUF5446 PF17522.2 ELR21391.1 - 0.089 13.0 0.0 0.17 12.1 0.0 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5446) Pkinase_Tyr PF07714.17 ELR21393.1 - 7.3e-26 91.0 0.0 1.6e-25 89.9 0.0 1.6 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ELR21393.1 - 1.6e-22 80.1 0.0 4.3e-22 78.7 0.0 1.7 1 0 0 1 1 1 1 Protein kinase domain Cornifin PF02389.15 ELR21395.1 - 0.78 9.9 96.1 0.068 13.4 45.8 3.6 1 1 2 3 3 3 0 Cornifin (SPRR) family Pribosyltran PF00156.27 ELR21396.1 - 1.8e-21 76.3 0.0 2.5e-21 75.8 0.0 1.2 1 0 0 1 1 1 1 Phosphoribosyl transferase domain PRTase_2 PF15609.6 ELR21396.1 - 0.004 16.7 0.0 0.033 13.7 0.0 2.0 2 0 0 2 2 2 1 Phosphoribosyl transferase UPRTase PF14681.6 ELR21396.1 - 0.0054 16.2 0.0 0.0074 15.7 0.0 1.3 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase D123 PF07065.14 ELR21397.1 - 7.4e-26 91.0 1.7 5.9e-24 84.8 0.4 2.3 2 0 0 2 2 2 2 D123 R2K_2 PF18299.1 ELR21397.1 - 2e-07 31.0 0.0 4.4e-07 29.9 0.0 1.5 1 0 0 1 1 1 1 ATP-grasp domain, R2K clade family 2 R2K_3 PF14243.6 ELR21397.1 - 0.00067 19.7 0.0 0.0015 18.6 0.0 1.5 1 0 0 1 1 1 1 ATP-grasp domain, R2K clade family 3 DUF3395 PF11875.8 ELR21398.1 - 3.3e-07 30.3 0.0 0.011 15.7 0.0 2.2 2 0 0 2 2 2 2 Domain of unknown function (DUF3395) Raffinose_syn PF05691.12 ELR21398.1 - 0.048 11.4 0.0 0.52 8.0 0.0 1.9 1 1 1 2 2 2 0 Raffinose synthase or seed imbibition protein Sip1 RVT_2 PF07727.14 ELR21400.1 - 5.3e-72 242.4 0.0 5.9e-72 242.2 0.0 1.0 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Get5_C PF18514.1 ELR21400.1 - 0.15 11.8 0.0 3.4 7.5 0.0 2.6 3 0 0 3 3 3 0 Get5 C-terminal domain adh_short_C2 PF13561.6 ELR21401.1 - 4.5e-48 163.8 0.0 5.4e-48 163.6 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 ELR21401.1 - 6.4e-46 156.3 0.1 8.6e-46 155.9 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 ELR21401.1 - 9e-08 32.2 0.0 1.4e-07 31.7 0.0 1.4 1 1 0 1 1 1 1 KR domain DUF1776 PF08643.10 ELR21401.1 - 0.0051 16.2 0.0 0.015 14.6 0.0 1.7 1 1 0 1 1 1 1 Fungal family of unknown function (DUF1776) TFIIB PF00382.19 ELR21401.1 - 0.027 14.5 0.1 1.4 9.1 0.0 2.4 2 0 0 2 2 2 0 Transcription factor TFIIB repeat Sacchrp_dh_NADP PF03435.18 ELR21401.1 - 0.048 13.9 0.0 0.078 13.2 0.0 1.4 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain Epimerase PF01370.21 ELR21401.1 - 0.16 11.4 0.0 13 5.2 0.0 2.2 2 0 0 2 2 2 0 NAD dependent epimerase/dehydratase family DUF1279 PF06916.13 ELR21402.1 - 1e-14 54.9 0.0 1.8e-14 54.1 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1279) TPR_1 PF00515.28 ELR21403.1 - 4.7e-16 57.8 1.9 8.2e-05 22.3 0.1 3.6 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 ELR21403.1 - 6.4e-15 54.0 4.6 5.2e-05 23.0 0.1 3.7 3 0 0 3 3 3 3 Tetratricopeptide repeat SET PF00856.28 ELR21403.1 - 9.3e-10 39.1 0.0 3.1e-08 34.2 0.0 2.3 1 1 0 1 1 1 1 SET domain TPR_11 PF13414.6 ELR21403.1 - 7.2e-08 32.0 6.7 0.02 14.6 0.1 4.2 3 1 2 5 5 5 3 TPR repeat TPR_19 PF14559.6 ELR21403.1 - 1.4e-05 25.5 0.4 0.0061 17.0 0.2 3.6 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_8 PF13181.6 ELR21403.1 - 1.9e-05 24.5 0.2 0.029 14.6 0.0 3.7 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.6 ELR21403.1 - 2.1e-05 24.9 6.0 0.012 16.4 0.1 4.0 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_9 PF13371.6 ELR21403.1 - 4.3e-05 23.6 3.2 7.1e-05 22.9 0.2 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_7 PF13176.6 ELR21403.1 - 7.8e-05 22.4 0.3 1.9 8.7 0.0 3.9 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.6 ELR21403.1 - 0.00011 22.5 8.7 0.00085 19.6 2.4 3.3 2 1 0 2 2 2 1 Tetratricopeptide repeat zf-MYND PF01753.18 ELR21403.1 - 0.00047 20.2 2.1 0.00047 20.2 2.1 2.6 3 0 0 3 3 2 1 MYND finger TPR_21 PF09976.9 ELR21403.1 - 0.0016 18.2 2.1 0.0036 17.0 0.1 2.3 2 0 0 2 2 2 1 Tetratricopeptide repeat-like domain TPR_17 PF13431.6 ELR21403.1 - 0.0033 17.7 0.0 0.031 14.7 0.0 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat NYD-SP12_N PF15015.6 ELR21403.1 - 0.0069 14.8 0.0 0.011 14.2 0.0 1.1 1 0 0 1 1 1 1 Spermatogenesis-associated, N-terminal zf-FCS PF06467.14 ELR21403.1 - 0.0099 15.8 0.5 0.072 13.0 0.0 2.5 2 0 0 2 2 2 1 MYM-type Zinc finger with FCS sequence motif TPR_16 PF13432.6 ELR21403.1 - 0.012 16.3 8.1 0.14 12.8 1.9 2.9 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_6 PF13174.6 ELR21403.1 - 0.062 14.0 2.4 0.58 10.9 0.1 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat BTAD PF03704.17 ELR21403.1 - 0.064 13.7 3.5 0.49 10.8 0.4 2.5 2 0 0 2 2 2 0 Bacterial transcriptional activator domain Tissue_fac PF01108.17 ELR21403.1 - 0.15 11.9 0.1 2.4 8.0 0.0 2.6 2 1 0 2 2 2 0 Tissue factor TPR_20 PF14561.6 ELR21403.1 - 0.15 12.4 0.3 0.4 11.0 0.3 1.7 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_MalT PF17874.1 ELR21403.1 - 0.16 11.3 1.6 2.3 7.5 0.4 2.4 2 0 0 2 2 2 0 MalT-like TPR region TPR_10 PF13374.6 ELR21403.1 - 0.4 10.6 6.4 15 5.6 0.2 3.7 3 0 0 3 3 3 0 Tetratricopeptide repeat zf-C6H2 PF15801.5 ELR21403.1 - 1.2 9.5 5.7 0.22 11.8 1.1 2.2 2 0 0 2 2 2 0 zf-MYND-like zinc finger, mRNA-binding FG-GAP PF01839.23 ELR21404.1 - 0.00033 20.7 2.0 0.00033 20.7 2.0 1.8 2 0 0 2 2 2 1 FG-GAP repeat VCBS PF13517.6 ELR21404.1 - 0.01 16.4 1.0 0.01 16.4 1.0 1.8 1 1 0 1 1 1 0 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella DUF3684 PF12449.8 ELR21405.1 - 3.1e-143 479.0 2.0 1.4e-85 288.1 0.0 5.0 3 2 2 5 5 5 5 Protein of unknown function (DUF3684) HATPase_c_3 PF13589.6 ELR21405.1 - 0.0015 18.4 0.0 2.4 8.0 0.0 2.7 2 0 0 2 2 2 2 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Proteasome PF00227.26 ELR21406.1 - 3.3e-22 78.9 0.1 7.7e-22 77.7 0.1 1.5 1 1 0 1 1 1 1 Proteasome subunit Fimbrial_PilY2 PF14481.6 ELR21406.1 - 0.01 15.5 0.0 0.021 14.5 0.0 1.5 1 0 0 1 1 1 1 Type 4 fimbrial biogenesis protein PilY2 DASH_Duo1 PF08651.10 ELR21407.1 - 0.055 13.2 0.3 0.075 12.8 0.3 1.2 1 0 0 1 1 1 0 DASH complex subunit Duo1 PSK_trans_fac PF07704.11 ELR21407.1 - 0.44 11.3 4.4 0.61 10.9 4.4 1.3 1 0 0 1 1 1 0 Rv0623-like transcription factor DAO PF01266.24 ELR21408.1 - 2.4e-59 201.7 0.0 2.7e-59 201.5 0.0 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 ELR21408.1 - 0.00051 19.2 0.1 0.00096 18.3 0.1 1.4 1 1 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 ELR21408.1 - 0.00056 19.2 1.3 0.21 10.8 0.3 2.2 1 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 ELR21408.1 - 0.00068 19.8 0.2 0.0014 18.8 0.2 1.5 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_oxidored PF12831.7 ELR21408.1 - 0.00087 18.7 0.3 0.21 10.9 0.1 2.1 2 0 0 2 2 2 2 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 ELR21408.1 - 0.0034 16.7 0.4 0.72 9.1 0.2 2.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 ELR21408.1 - 0.076 13.6 0.7 0.93 10.1 0.2 2.6 2 1 1 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 ELR21408.1 - 0.085 12.8 0.5 9.1 6.3 0.1 2.4 2 0 0 2 2 2 0 FAD-NAD(P)-binding TrkA_N PF02254.18 ELR21408.1 - 0.11 12.7 0.0 0.38 11.0 0.0 1.9 2 0 0 2 2 2 0 TrkA-N domain AlaDh_PNT_C PF01262.21 ELR21408.1 - 0.14 11.5 0.0 0.21 10.9 0.0 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain HI0933_like PF03486.14 ELR21408.1 - 0.27 9.9 0.7 0.42 9.2 0.2 1.5 2 0 0 2 2 2 0 HI0933-like protein FAD_binding_3 PF01494.19 ELR21408.1 - 0.66 9.2 1.9 0.43 9.8 0.3 1.4 2 0 0 2 2 2 0 FAD binding domain MFS_1 PF07690.16 ELR21410.1 - 6.2e-24 84.6 34.7 2.1e-16 59.8 12.4 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 ELR21410.1 - 0.0027 16.3 6.8 0.0027 16.3 6.8 3.9 2 2 2 4 4 4 3 MFS/sugar transport protein Nodulin-like PF06813.13 ELR21410.1 - 0.0029 17.1 7.3 0.0029 17.1 7.3 3.0 3 1 0 4 4 4 1 Nodulin-like DUF4179 PF13786.6 ELR21410.1 - 1.2 9.7 8.1 7.2 7.2 0.0 4.0 3 1 0 3 3 3 0 Domain of unknown function (DUF4179) BTB PF00651.31 ELR21411.1 - 1.3e-31 109.1 0.1 2.5e-17 63.1 0.0 3.3 2 1 1 3 3 3 3 BTB/POZ domain LRR_4 PF12799.7 ELR21411.1 - 5.7e-07 29.8 1.2 0.015 15.7 0.1 2.5 2 0 0 2 2 2 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 ELR21411.1 - 1.4e-05 24.8 1.2 3.6e-05 23.4 1.2 1.7 1 0 0 1 1 1 1 Leucine rich repeat BACK PF07707.15 ELR21411.1 - 0.051 13.7 0.2 1.1 9.4 0.0 3.0 2 1 1 3 3 3 0 BTB And C-terminal Kelch TFIIA PF03153.13 ELR21411.1 - 0.24 11.4 11.0 0.34 10.8 11.0 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Borrelia_P83 PF05262.11 ELR21411.1 - 0.44 9.0 9.1 0.64 8.5 9.1 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein Glyco_hydro_35 PF01301.19 ELR21412.1 - 2e-111 372.7 0.0 2.4e-111 372.4 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 35 Glyco_hydro_42 PF02449.15 ELR21412.1 - 3.2e-13 49.8 0.0 2.8e-11 43.4 0.0 2.2 1 1 0 1 1 1 1 Beta-galactosidase EF-hand_1 PF00036.32 ELR21413.1 - 2.8e-22 76.6 14.3 3.6e-06 26.1 0.1 4.7 4 0 0 4 4 4 3 EF hand EF-hand_7 PF13499.6 ELR21413.1 - 3.8e-20 72.1 7.0 2.4e-13 50.3 0.5 3.8 2 1 0 3 3 3 3 EF-hand domain pair EF-hand_6 PF13405.6 ELR21413.1 - 2.1e-18 64.6 11.3 1.3e-05 24.8 0.2 4.5 4 0 0 4 4 4 3 EF-hand domain EF-hand_8 PF13833.6 ELR21413.1 - 3e-16 59.0 7.0 3.1e-05 23.7 1.0 3.9 3 1 0 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.6 ELR21413.1 - 2.6e-14 51.9 14.7 0.00023 20.5 0.4 4.1 4 0 0 4 4 4 3 EF hand SPRY PF00622.28 ELR21413.1 - 1.1e-12 48.1 0.3 1.9e-12 47.3 0.3 1.4 1 0 0 1 1 1 1 SPRY domain SPARC_Ca_bdg PF10591.9 ELR21413.1 - 1.1e-05 25.7 0.1 2.2 8.6 0.0 3.4 2 1 1 3 3 3 3 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 ELR21413.1 - 0.00013 21.9 2.9 0.27 11.2 0.3 3.3 2 1 1 3 3 3 2 Cytoskeletal-regulatory complex EF hand DUF3553 PF12073.8 ELR21413.1 - 0.093 12.5 0.0 0.18 11.5 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3553) Pkinase PF00069.25 ELR21414.1 - 2.5e-64 217.2 0.0 4.9e-64 216.2 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR21414.1 - 6.9e-33 114.0 0.0 1.1e-32 113.4 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase AdenylateSensor PF16579.5 ELR21414.1 - 2.3e-07 31.3 0.0 0.019 15.4 0.0 2.6 2 0 0 2 2 2 2 Adenylate sensor of SNF1-like protein kinase KA1 PF02149.19 ELR21414.1 - 3.6e-06 26.7 0.1 7.2e-06 25.7 0.1 1.5 1 0 0 1 1 1 1 Kinase associated domain 1 RIO1 PF01163.22 ELR21414.1 - 0.0001 21.9 0.5 0.00024 20.8 0.5 1.5 1 0 0 1 1 1 1 RIO1 family APH PF01636.23 ELR21414.1 - 0.00019 21.4 0.2 0.047 13.6 0.4 2.2 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.14 ELR21414.1 - 0.0094 15.3 0.1 0.02 14.2 0.1 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pox_ser-thr_kin PF05445.11 ELR21414.1 - 0.11 11.5 0.1 0.22 10.5 0.1 1.4 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Choline_kinase PF01633.20 ELR21414.1 - 0.16 11.6 0.2 0.27 10.8 0.2 1.4 1 0 0 1 1 1 0 Choline/ethanolamine kinase Hydrolase_4 PF12146.8 ELR21415.1 - 1.9e-62 210.7 0.0 2.5e-62 210.3 0.0 1.1 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 ELR21415.1 - 8.9e-12 45.2 0.2 1.2e-09 38.2 0.1 2.2 1 1 0 2 2 2 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 ELR21415.1 - 4.6e-06 26.3 0.1 0.019 14.4 0.0 2.3 2 0 0 2 2 2 2 Prolyl oligopeptidase family Esterase PF00756.20 ELR21415.1 - 4.4e-05 23.2 0.0 9.5e-05 22.2 0.0 1.5 1 0 0 1 1 1 1 Putative esterase Peptidase_S10 PF00450.22 ELR21415.1 - 0.0011 18.4 0.2 0.46 9.8 0.0 2.1 2 0 0 2 2 2 2 Serine carboxypeptidase DLH PF01738.18 ELR21415.1 - 0.032 13.8 0.0 0.47 10.0 0.0 2.1 2 0 0 2 2 2 0 Dienelactone hydrolase family DUF2920 PF11144.8 ELR21415.1 - 0.036 13.3 0.0 0.85 8.7 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2920) DUF3460 PF11943.8 ELR21415.1 - 0.036 14.3 0.2 0.09 13.0 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3460) Abhydrolase_5 PF12695.7 ELR21415.1 - 0.037 13.8 0.0 0.12 12.1 0.0 1.8 2 0 0 2 2 2 0 Alpha/beta hydrolase family 2-Hacid_dh_C PF02826.19 ELR21416.1 - 6.9e-57 191.7 0.0 1.2e-56 190.9 0.0 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 ELR21416.1 - 6.1e-32 110.1 0.0 9.1e-32 109.5 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain cNMP_binding PF00027.29 ELR21416.1 - 1.6e-12 47.3 0.0 3.3e-12 46.3 0.0 1.6 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain NAD_binding_2 PF03446.15 ELR21416.1 - 9.8e-05 22.6 0.1 0.00026 21.2 0.1 1.7 2 0 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase IlvN PF07991.12 ELR21416.1 - 0.029 14.0 0.1 0.24 11.0 0.0 2.1 2 0 0 2 2 2 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain UDPG_MGDP_dh_N PF03721.14 ELR21416.1 - 0.053 13.1 1.8 1.1 8.8 0.5 2.5 2 0 0 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain 3HCDH_N PF02737.18 ELR21416.1 - 0.061 13.2 0.0 0.11 12.3 0.0 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Rossmann-like PF10727.9 ELR21416.1 - 0.064 13.1 0.1 0.35 10.7 0.0 2.1 2 0 0 2 2 2 0 Rossmann-like domain NAD_binding_7 PF13241.6 ELR21416.1 - 0.086 13.3 0.1 0.83 10.1 0.0 2.4 2 0 0 2 2 2 0 Putative NAD(P)-binding Shikimate_DH PF01488.20 ELR21416.1 - 0.089 12.9 0.0 0.24 11.4 0.0 1.8 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase BPL_N PF09825.9 ELR21417.1 - 2.5e-69 234.2 0.0 3.3e-69 233.8 0.0 1.0 1 0 0 1 1 1 1 Biotin-protein ligase, N terminal GATase_3 PF07685.14 ELR21417.1 - 0.034 13.7 0.0 0.048 13.3 0.0 1.2 1 0 0 1 1 1 0 CobB/CobQ-like glutamine amidotransferase domain DUF2017 PF09438.10 ELR21417.1 - 0.14 12.0 0.9 0.35 10.7 0.9 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF2017) CLU PF13236.6 ELR21418.1 - 3e-44 151.5 0.0 9e-43 146.7 0.0 2.5 1 1 0 1 1 1 1 Clustered mitochondria eIF3_p135 PF12807.7 ELR21418.1 - 1.3e-07 31.8 0.0 1.3e-07 31.8 0.0 3.1 3 0 0 3 3 3 1 Translation initiation factor eIF3 subunit 135 LRR_6 PF13516.6 ELR21418.1 - 1.1e-05 25.1 4.1 0.67 10.2 0.0 5.3 5 0 0 5 5 5 2 Leucine Rich repeat LigT_PEase PF02834.16 ELR21418.1 - 0.32 11.2 1.9 13 6.1 0.0 3.2 3 0 0 3 3 3 0 LigT like Phosphoesterase BSP_II PF05432.11 ELR21419.1 - 0.73 9.5 23.1 1.2 8.8 23.1 1.4 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) CAC1F_C PF16885.5 ELR21419.1 - 4.5 6.8 10.7 7.2 6.2 10.7 1.3 1 0 0 1 1 1 0 Voltage-gated calcium channel subunit alpha, C-term DUF4407 PF14362.6 ELR21419.1 - 4.6 6.5 9.3 9.2 5.5 9.3 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) FKBP_C PF00254.28 ELR21420.1 - 2e-24 85.7 0.0 2.4e-24 85.5 0.0 1.0 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase Parvo_NS1 PF01057.17 ELR21420.1 - 0.16 11.1 0.0 0.16 11.0 0.0 1.1 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 Epimerase PF01370.21 ELR21421.1 - 8.2e-44 149.9 0.0 1.2e-43 149.3 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 ELR21421.1 - 1.2e-22 80.7 0.0 3.9e-21 75.8 0.0 2.1 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase 3Beta_HSD PF01073.19 ELR21421.1 - 2.6e-09 36.5 0.0 3.8e-09 35.9 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.6 ELR21421.1 - 8.1e-07 29.1 0.0 1.3e-06 28.5 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding Polysacc_synt_2 PF02719.15 ELR21421.1 - 7e-05 22.1 0.0 0.0012 18.1 0.0 2.1 2 0 0 2 2 2 1 Polysaccharide biosynthesis protein NAD_binding_4 PF07993.12 ELR21421.1 - 0.0003 20.0 0.0 0.0093 15.2 0.0 2.2 2 0 0 2 2 2 1 Male sterility protein RmlD_sub_bind PF04321.17 ELR21421.1 - 0.0011 18.2 0.0 0.0018 17.4 0.0 1.3 1 0 0 1 1 1 1 RmlD substrate binding domain Methyltransf_16 PF10294.9 ELR21422.1 - 1.7e-26 93.0 0.0 2.6e-26 92.4 0.0 1.1 1 0 0 1 1 1 1 Lysine methyltransferase Ank_2 PF12796.7 ELR21423.1 - 1.7e-26 92.6 1.6 1.6e-10 41.5 0.4 4.4 2 1 2 4 4 4 3 Ankyrin repeats (3 copies) Ank_3 PF13606.6 ELR21423.1 - 6e-24 81.5 0.1 0.0012 19.2 0.0 6.5 6 0 0 6 6 6 6 Ankyrin repeat Ank_4 PF13637.6 ELR21423.1 - 2.9e-23 81.9 3.9 2e-07 31.4 0.1 5.2 3 1 2 5 5 5 4 Ankyrin repeats (many copies) Ank_5 PF13857.6 ELR21423.1 - 5.8e-18 64.7 0.4 0.074 13.4 0.0 6.4 4 2 2 6 6 6 5 Ankyrin repeats (many copies) Ank PF00023.30 ELR21423.1 - 6.4e-15 54.8 1.0 0.041 14.3 0.1 6.6 6 0 0 6 6 6 5 Ankyrin repeat F-box-like PF12937.7 ELR21423.1 - 4e-05 23.4 0.1 7.4e-05 22.6 0.1 1.4 1 0 0 1 1 1 1 F-box-like PfkB PF00294.24 ELR21424.1 - 1e-30 107.1 0.0 6.8e-15 55.1 0.0 3.1 2 1 0 2 2 2 2 pfkB family carbohydrate kinase Kelch_4 PF13418.6 ELR21425.1 - 0.001 19.1 0.8 0.18 11.8 0.0 3.0 2 2 0 2 2 2 2 Galactose oxidase, central domain Kelch_6 PF13964.6 ELR21425.1 - 0.065 13.5 0.0 4.3 7.8 0.0 2.4 1 1 1 2 2 2 0 Kelch motif Citrate_synt PF00285.21 ELR21426.1 - 4.9e-99 331.8 0.0 6.3e-99 331.5 0.0 1.1 1 0 0 1 1 1 1 Citrate synthase, C-terminal domain DUF1264 PF06884.11 ELR21427.1 - 9.1e-63 210.9 0.0 1.1e-62 210.6 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1264) COesterase PF00135.28 ELR21428.1 - 5.3e-101 339.0 0.0 7.1e-101 338.6 0.0 1.1 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 ELR21428.1 - 2.1e-09 37.5 0.3 9.2e-09 35.5 0.3 1.9 1 1 0 1 1 1 1 alpha/beta hydrolase fold Say1_Mug180 PF10340.9 ELR21428.1 - 0.13 11.1 0.1 0.69 8.7 0.1 1.9 1 1 0 1 1 1 0 Steryl acetyl hydrolase Ank_2 PF12796.7 ELR21429.1 - 8.8e-27 93.5 17.3 1.1e-12 48.4 2.9 3.4 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank_3 PF13606.6 ELR21429.1 - 1.9e-17 61.5 2.1 0.0022 18.3 0.0 5.5 4 1 1 5 5 5 4 Ankyrin repeat Ank_4 PF13637.6 ELR21429.1 - 1.7e-16 60.3 9.3 1.1e-11 45.0 0.6 5.3 4 1 2 6 6 6 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 ELR21429.1 - 2.6e-15 56.3 6.5 6.5e-06 26.3 0.0 4.7 4 1 1 5 5 5 3 Ankyrin repeats (many copies) Ank PF00023.30 ELR21429.1 - 2.3e-12 46.8 7.0 0.002 18.5 0.0 4.7 4 0 0 4 4 4 2 Ankyrin repeat F-box-like PF12937.7 ELR21429.1 - 0.00044 20.1 2.4 0.00066 19.5 0.6 2.3 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 ELR21429.1 - 0.0032 17.3 1.5 0.006 16.4 0.1 2.0 2 0 0 2 2 2 1 F-box domain Amidase_5 PF05382.13 ELR21429.1 - 0.0052 16.7 0.0 2.8 7.8 0.0 2.5 2 0 0 2 2 2 2 Bacteriophage peptidoglycan hydrolase Phospholip_B PF04916.13 ELR21430.1 - 2.5e-163 544.5 10.1 1e-162 542.5 10.1 1.7 1 1 0 1 1 1 1 Phospholipase B Synapsin_C PF02750.14 ELR21431.1 - 1.5e-41 142.2 0.1 2.2e-39 135.1 0.0 2.7 2 1 0 2 2 2 1 Synapsin, ATP binding domain Synapsin PF02078.16 ELR21431.1 - 1.2e-21 76.9 0.0 4.1e-21 75.2 0.0 1.9 2 0 0 2 2 2 1 Synapsin, N-terminal domain DUF3464 PF11947.8 ELR21431.1 - 0.76 9.5 6.3 2.2 8.0 6.3 1.8 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 Glyco_hydro_18 PF00704.28 ELR21432.1 - 3.2e-25 89.5 0.6 1.6e-24 87.2 0.6 1.9 1 1 0 1 1 1 1 Glycosyl hydrolases family 18 ssDBP PF17878.1 ELR21432.1 - 0.12 12.6 0.2 0.38 11.0 0.0 1.9 1 1 1 2 2 2 0 Single-stranded DNA-binding protein SDA1 PF05285.12 ELR21433.1 - 1.1e-06 28.4 18.4 1.4e-06 28.0 18.4 1.2 1 0 0 1 1 1 1 SDA1 MDM1 PF15501.6 ELR21433.1 - 0.01 15.1 6.3 0.016 14.4 6.3 1.3 1 0 0 1 1 1 0 Nuclear protein MDM1 Nop14 PF04147.12 ELR21433.1 - 0.011 14.0 31.3 0.014 13.6 31.3 1.1 1 0 0 1 1 1 0 Nop14-like family FAM60A PF15396.6 ELR21433.1 - 0.018 15.1 5.1 0.031 14.3 5.1 1.3 1 0 0 1 1 1 0 Protein Family FAM60A Mpp10 PF04006.12 ELR21433.1 - 0.026 13.0 26.6 0.037 12.5 26.6 1.2 1 0 0 1 1 1 0 Mpp10 protein RP-C_C PF11800.8 ELR21433.1 - 0.053 13.6 4.6 0.062 13.4 3.6 1.6 2 0 0 2 2 2 0 Replication protein C C-terminal region Presenilin PF01080.17 ELR21433.1 - 0.057 12.2 6.5 0.073 11.8 6.5 1.1 1 0 0 1 1 1 0 Presenilin F-box-like PF12937.7 ELR21433.1 - 0.065 13.1 1.0 0.099 12.6 0.2 1.8 2 0 0 2 2 1 0 F-box-like F-box PF00646.33 ELR21433.1 - 0.11 12.4 0.1 0.27 11.2 0.1 1.6 1 0 0 1 1 1 0 F-box domain Zip PF02535.22 ELR21433.1 - 0.12 11.5 9.4 0.19 10.9 9.4 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter RR_TM4-6 PF06459.12 ELR21433.1 - 0.16 11.7 13.5 0.3 10.9 13.5 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 BUD22 PF09073.10 ELR21433.1 - 0.18 11.1 27.9 0.33 10.2 27.9 1.4 1 0 0 1 1 1 0 BUD22 CDC45 PF02724.14 ELR21433.1 - 0.21 9.9 25.7 0.31 9.3 25.7 1.2 1 0 0 1 1 1 0 CDC45-like protein SAPS PF04499.15 ELR21433.1 - 0.21 10.3 18.2 0.3 9.8 18.2 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein CobT PF06213.12 ELR21433.1 - 0.27 10.6 27.8 0.47 9.8 27.8 1.4 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT DUF913 PF06025.12 ELR21433.1 - 0.92 8.4 7.2 1.9 7.4 7.2 1.5 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) NARP1 PF12569.8 ELR21433.1 - 1.2 8.0 18.4 1.7 7.4 18.4 1.2 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 MDM10 PF12519.8 ELR21433.1 - 1.6 7.5 4.2 2.2 7.0 4.2 1.3 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 Hid1 PF12722.7 ELR21433.1 - 1.6 6.7 6.2 2.1 6.4 6.2 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein NPR3 PF03666.13 ELR21433.1 - 2.2 7.0 15.4 3.3 6.4 15.4 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Tim54 PF11711.8 ELR21433.1 - 8.7 5.0 12.8 15 4.2 12.8 1.3 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 FRQ PF09421.10 ELR21433.1 - 9 4.2 17.5 12 3.7 17.5 1.1 1 0 0 1 1 1 0 Frequency clock protein Methyltransf_21 PF05050.12 ELR21434.1 - 3.4e-05 23.9 0.2 8.5e-05 22.6 0.1 1.6 1 1 1 2 2 2 1 Methyltransferase FkbM domain DNA_ligase_OB_2 PF14743.6 ELR21435.1 - 7.7e-29 99.5 0.1 2.1e-28 98.1 0.1 1.8 1 0 0 1 1 1 1 DNA ligase OB-like domain zf-CCHH PF10283.9 ELR21435.1 - 2.9e-11 43.2 1.4 5.9e-11 42.1 1.4 1.6 1 0 0 1 1 1 1 PBZ domain DNA_ligase_A_M PF01068.21 ELR21435.1 - 9.6e-08 31.9 0.3 3.8e-07 29.9 0.0 2.1 2 1 0 2 2 2 1 ATP dependent DNA ligase domain BRCT PF00533.26 ELR21435.1 - 7.5e-06 26.2 0.0 1.7e-05 25.1 0.0 1.6 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain RNA_ligase PF09414.10 ELR21435.1 - 0.00042 20.7 0.0 0.0014 18.9 0.0 2.0 1 1 0 1 1 1 1 RNA ligase PTCB-BRCT PF12738.7 ELR21435.1 - 0.00058 19.8 0.2 0.0013 18.6 0.2 1.5 1 0 0 1 1 1 1 twin BRCT domain FHA PF00498.26 ELR21435.1 - 0.012 16.0 0.0 0.023 15.0 0.0 1.5 1 0 0 1 1 1 0 FHA domain FHA_2 PF17913.1 ELR21435.1 - 0.029 14.6 0.0 0.071 13.4 0.0 1.6 1 0 0 1 1 1 0 FHA domain Dicty_CAR PF05462.11 ELR21437.1 - 1.3e-07 31.1 14.0 1.7e-07 30.7 14.0 1.2 1 0 0 1 1 1 1 Slime mold cyclic AMP receptor Frizzled PF01534.17 ELR21437.1 - 4.6e-07 29.2 11.9 0.00092 18.3 1.8 2.2 1 1 1 2 2 2 2 Frizzled/Smoothened family membrane region 7tm_1 PF00001.21 ELR21437.1 - 9e-06 25.2 10.9 1.6e-05 24.4 10.9 1.4 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Git3 PF11710.8 ELR21437.1 - 1.9 8.2 14.3 84 2.8 14.3 2.4 1 1 0 1 1 1 0 G protein-coupled glucose receptor regulating Gpa2 tRNA-synt_2 PF00152.20 ELR21439.1 - 1.7e-73 247.5 0.0 1.6e-46 158.9 0.0 2.1 1 1 1 2 2 2 2 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 ELR21439.1 - 2.9e-13 49.6 0.0 5.5e-13 48.7 0.0 1.5 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain GAD PF02938.14 ELR21439.1 - 3.6e-11 43.1 0.0 7.3e-11 42.2 0.0 1.4 1 0 0 1 1 1 1 GAD domain SET PF00856.28 ELR21440.1 - 1.6e-06 28.6 0.0 2.7e-06 27.9 0.0 1.4 1 0 0 1 1 1 1 SET domain zf-MYND PF01753.18 ELR21440.1 - 0.00029 20.9 1.8 0.00029 20.9 1.8 2.7 2 1 0 2 2 2 1 MYND finger LTXXQ PF07813.12 ELR21440.1 - 4.5 8.1 7.6 4.4 8.1 0.1 3.3 3 1 0 3 3 3 0 LTXXQ motif family protein AidB_N PF18158.1 ELR21441.1 - 9.6e-24 84.1 0.0 2.3e-23 82.9 0.0 1.6 1 0 0 1 1 1 1 Adaptive response protein AidB N-terminal domain Acyl-CoA_dh_1 PF00441.24 ELR21441.1 - 5.1e-23 81.9 1.2 5.1e-23 81.9 1.2 2.1 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 ELR21441.1 - 4.4e-12 46.0 0.0 8.4e-12 45.1 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.11 ELR21441.1 - 2.1e-06 28.1 0.6 2.1e-06 28.1 0.6 2.1 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_C PF12806.7 ELR21441.1 - 0.084 13.0 0.5 0.27 11.4 0.5 1.9 1 0 0 1 1 1 0 Acetyl-CoA dehydrogenase C-terminal like PMEI PF04043.15 ELR21441.1 - 0.34 11.3 1.1 0.84 10.0 0.1 2.1 1 1 1 2 2 2 0 Plant invertase/pectin methylesterase inhibitor RFX_DNA_binding PF02257.15 ELR21442.1 - 5.8e-09 36.5 0.0 1e-08 35.7 0.0 1.3 1 0 0 1 1 1 1 RFX DNA-binding domain PIP5K PF01504.18 ELR21444.1 - 3.9e-69 232.9 0.0 6.8e-69 232.1 0.0 1.3 1 0 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase EF-hand_7 PF13499.6 ELR21444.1 - 2.3e-09 37.6 0.4 0.0013 19.1 0.0 2.7 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_1 PF00036.32 ELR21444.1 - 1.1e-08 34.0 4.9 0.00067 19.0 0.4 2.7 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 ELR21444.1 - 1.8e-08 33.6 3.3 0.0019 18.0 0.8 2.9 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.6 ELR21444.1 - 5e-06 25.8 2.5 0.013 15.0 0.3 2.6 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 ELR21444.1 - 0.00024 20.9 2.3 0.00024 20.9 2.3 2.8 2 1 1 3 3 3 2 EF-hand domain pair SPARC_Ca_bdg PF10591.9 ELR21444.1 - 0.0041 17.4 1.9 0.0051 17.1 0.2 2.0 2 1 0 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region Phage_TAC_7 PF10109.9 ELR21444.1 - 0.035 14.2 0.1 0.074 13.2 0.1 1.5 1 0 0 1 1 1 0 Phage tail assembly chaperone proteins, E, or 41 or 14 Gly_kinase PF02595.15 ELR21445.1 - 2.6e-93 313.0 1.3 3.7e-93 312.5 1.3 1.1 1 0 0 1 1 1 1 Glycerate kinase family HSP20 PF00011.21 ELR21446.1 - 8.7e-22 77.2 0.1 1.5e-19 70.0 0.1 2.2 1 1 0 1 1 1 1 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 ELR21446.1 - 4e-09 35.9 0.0 6.8e-09 35.2 0.0 1.4 1 0 0 1 1 1 1 HSP20-like domain found in ArsA Phage_sheath_1N PF17481.2 ELR21446.1 - 0.042 14.3 0.1 0.11 13.0 0.0 1.8 2 0 0 2 2 2 0 Phage tail sheath protein beta-sandwich domain Secretin PF00263.21 ELR21446.1 - 0.19 11.4 3.3 0.17 11.5 1.8 1.6 2 0 0 2 2 2 0 Bacterial type II and III secretion system protein PAP1 PF08601.10 ELR21446.1 - 3.6 7.2 10.8 0.75 9.5 7.4 1.6 2 0 0 2 2 2 0 Transcription factor PAP1 SRP9-21 PF05486.12 ELR21447.1 - 3.9e-12 46.4 2.2 1.8e-10 41.0 2.2 2.0 1 1 0 1 1 1 1 Signal recognition particle 9 kDa protein (SRP9) Rap_GAP PF02145.15 ELR21448.1 - 8e-59 198.3 0.0 1.2e-58 197.8 0.0 1.3 1 0 0 1 1 1 1 Rap/ran-GAP TssR PF17643.1 ELR21448.1 - 0.065 11.2 0.1 0.086 10.8 0.1 1.1 1 0 0 1 1 1 0 Type VI secretion system, TssR Rsa3 PF14615.6 ELR21449.1 - 1e-08 34.6 0.2 2.2e-08 33.5 0.2 1.6 1 0 0 1 1 1 1 Ribosome-assembly protein 3 Phosphoesterase PF04185.14 ELR21450.1 - 2.8e-83 280.0 0.7 5.7e-83 279.0 0.1 1.7 2 0 0 2 2 2 1 Phosphoesterase family DUF824 PF05688.11 ELR21451.1 - 0.092 12.6 0.0 0.36 10.7 0.0 2.0 1 0 0 1 1 1 0 Salmonella repeat of unknown function (DUF824) Oxidored_q5_N PF01059.17 ELR21451.1 - 0.61 10.2 5.5 0.15 12.2 0.6 2.3 2 0 0 2 2 2 0 NADH-ubiquinone oxidoreductase chain 4, amino terminus ICMT PF04140.14 ELR21452.1 - 1.2e-28 99.4 0.3 2.6e-28 98.3 0.3 1.6 1 0 0 1 1 1 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family PEMT PF04191.13 ELR21452.1 - 1.7e-06 28.4 0.4 1.7e-06 28.4 0.4 2.4 2 0 0 2 2 2 1 Phospholipid methyltransferase DUF1295 PF06966.12 ELR21452.1 - 9e-05 22.1 3.9 9e-05 22.1 3.9 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF1295) RWD PF05773.22 ELR21453.1 - 4.9e-13 49.4 0.0 9.3e-13 48.5 0.0 1.5 1 0 0 1 1 1 1 RWD domain IBR PF01485.21 ELR21453.1 - 4e-08 33.3 15.4 6.5e-08 32.7 5.5 2.8 2 0 0 2 2 2 1 IBR domain, a half RING-finger domain zf-RING_UBOX PF13445.6 ELR21453.1 - 4.8e-07 29.7 1.4 4.8e-07 29.7 1.4 2.6 2 0 0 2 2 2 1 RING-type zinc-finger zf-RING_2 PF13639.6 ELR21453.1 - 7.7e-06 26.2 5.0 7.7e-06 26.2 5.0 2.7 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_2 PF13923.6 ELR21453.1 - 1e-05 25.3 2.7 1e-05 25.3 2.7 3.0 2 1 1 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ELR21453.1 - 0.00014 21.8 6.1 0.00014 21.8 6.1 2.8 2 1 0 2 2 2 1 zinc-RING finger domain zf-C3HC4 PF00097.25 ELR21453.1 - 0.001 18.9 4.8 0.001 18.9 4.8 2.6 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 ELR21453.1 - 0.39 10.6 16.2 0.32 10.9 1.4 2.8 2 0 0 2 2 2 0 Prokaryotic RING finger family 4 Zn_Tnp_IS91 PF14319.6 ELR21453.1 - 1.9 8.5 12.1 0.76 9.9 1.3 2.7 2 0 0 2 2 2 0 Transposase zinc-binding domain zf-RING_11 PF17123.5 ELR21453.1 - 3.8 7.4 13.5 0.023 14.4 3.1 2.5 2 0 0 2 2 2 0 RING-like zinc finger S36_mt PF10937.8 ELR21454.1 - 1.9e-05 26.2 0.1 5.2e-05 24.8 0.1 1.6 1 1 0 1 1 1 1 Ribosomal protein S36, mitochondrial SAP30_Sin3_bdg PF13867.6 ELR21455.1 - 2e-11 44.1 0.1 3.4e-11 43.3 0.1 1.4 1 0 0 1 1 1 1 Sin3 binding region of histone deacetylase complex subunit SAP30 Med3 PF11593.8 ELR21455.1 - 0.57 9.3 4.4 0.75 8.9 4.4 1.1 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal SR-25 PF10500.9 ELR21455.1 - 2 8.0 12.1 2.7 7.5 12.1 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Chorion_2 PF03964.15 ELR21455.1 - 3.1 8.7 10.2 3.1 8.7 8.1 1.9 2 0 0 2 2 2 0 Chorion family 2 Rhodanese_C PF12368.8 ELR21456.1 - 9.6e-12 45.1 9.6 3.1e-11 43.5 9.8 1.8 1 1 1 2 2 2 1 Rhodanase C-terminal UPF0176_N PF17773.1 ELR21456.1 - 6.3e-09 36.1 0.0 1.3e-08 35.0 0.0 1.6 1 0 0 1 1 1 1 UPF0176 acylphosphatase like domain Rhodanese PF00581.20 ELR21456.1 - 1.2e-05 25.7 3.0 4.5e-05 23.9 0.0 2.9 3 0 0 3 3 3 1 Rhodanese-like domain Otopetrin PF03189.13 ELR21456.1 - 2.6 6.8 3.0 3.8 6.2 3.0 1.3 1 0 0 1 1 1 0 Otopetrin HMG_box PF00505.19 ELR21457.1 - 8.9e-21 74.1 3.7 8.9e-21 74.1 3.7 1.8 2 0 0 2 2 2 1 HMG (high mobility group) box HMG_box_2 PF09011.10 ELR21457.1 - 4.7e-18 65.6 2.2 4.7e-18 65.6 2.2 2.1 2 0 0 2 2 2 1 HMG-box domain HMG_box_5 PF14887.6 ELR21457.1 - 3.4e-05 23.7 3.0 3.4e-05 23.7 3.0 2.2 1 1 1 2 2 2 1 HMG (high mobility group) box 5 ubiquitin PF00240.23 ELR21458.1 - 1.3e-34 117.8 0.8 1.3e-34 117.8 0.8 1.6 2 0 0 2 2 2 1 Ubiquitin family Ribosomal_S27 PF01599.19 ELR21458.1 - 6.4e-28 96.7 2.3 6.4e-28 96.7 2.3 1.8 2 0 0 2 2 2 1 Ribosomal protein S27a Rad60-SLD PF11976.8 ELR21458.1 - 9.8e-17 60.6 0.8 9.8e-17 60.6 0.8 1.6 2 0 0 2 2 2 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 ELR21458.1 - 8.5e-06 26.1 0.4 4e-05 24.0 0.2 2.1 2 1 0 2 2 2 1 Ubiquitin-like domain Rad60-SLD_2 PF13881.6 ELR21458.1 - 0.00077 19.6 0.7 0.0016 18.5 0.7 1.6 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.9 ELR21458.1 - 0.0024 18.4 0.8 0.0033 17.9 0.8 1.2 1 0 0 1 1 1 1 DUF2407 ubiquitin-like domain TBK1_ULD PF18396.1 ELR21458.1 - 0.0038 17.1 0.1 0.0059 16.5 0.1 1.3 1 0 0 1 1 1 1 TANK binding kinase 1 ubiquitin-like domain Ubiquitin_5 PF18037.1 ELR21458.1 - 0.005 17.2 0.9 0.0082 16.5 0.1 1.7 1 1 1 2 2 2 1 Ubiquitin-like domain IBR PF01485.21 ELR21458.1 - 0.0056 16.9 0.3 0.0098 16.1 0.3 1.4 1 0 0 1 1 1 1 IBR domain, a half RING-finger domain Ubiquitin_4 PF18036.1 ELR21458.1 - 0.013 15.5 1.2 2.7 8.1 0.2 2.5 2 0 0 2 2 2 0 Ubiquitin-like domain Plexin_cytopl PF08337.12 ELR21458.1 - 0.09 11.4 1.2 5.1 5.6 0.3 2.2 2 0 0 2 2 2 0 Plexin cytoplasmic RasGAP domain Hist_deacetyl PF00850.19 ELR21459.1 - 3.7e-88 296.0 0.0 4.9e-88 295.5 0.0 1.2 1 0 0 1 1 1 1 Histone deacetylase domain Lipase_GDSL_2 PF13472.6 ELR21459.1 - 0.022 15.2 0.3 0.084 13.3 0.1 2.0 2 0 0 2 2 2 0 GDSL-like Lipase/Acylhydrolase family WD40 PF00400.32 ELR21460.1 - 1.7e-18 66.6 22.8 9.7e-06 26.2 0.1 6.9 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ELR21460.1 - 4.7e-16 58.9 4.8 8e-07 29.3 0.1 4.4 3 1 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ELR21460.1 - 1.3e-05 24.3 0.7 0.077 12.0 0.0 3.5 1 1 0 3 3 3 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Tetraspanin PF00335.20 ELR21461.1 - 1e-05 25.4 2.5 1e-05 25.4 2.5 1.7 1 1 1 2 2 2 1 Tetraspanin family Vma12 PF11712.8 ELR21461.1 - 0.021 14.9 0.3 0.045 13.8 0.3 1.5 1 1 0 1 1 1 0 Endoplasmic reticulum-based factor for assembly of V-ATPase ING PF12998.7 ELR21462.1 - 3.3e-25 88.6 5.6 3e-24 85.5 5.6 2.0 1 1 0 1 1 1 1 Inhibitor of growth proteins N-terminal histone-binding PHD PF00628.29 ELR21462.1 - 1.3e-06 28.1 6.8 2.1e-06 27.5 6.8 1.3 1 0 0 1 1 1 1 PHD-finger PHD_2 PF13831.6 ELR21462.1 - 0.0021 17.6 2.0 0.0033 16.9 2.0 1.4 1 0 0 1 1 1 1 PHD-finger FliJ PF02050.16 ELR21462.1 - 0.013 15.7 8.1 0.11 12.7 7.9 2.0 1 1 0 1 1 1 0 Flagellar FliJ protein Fib_alpha PF08702.10 ELR21462.1 - 0.027 14.6 3.7 0.038 14.2 3.7 1.3 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family Not3 PF04065.15 ELR21462.1 - 0.047 13.1 9.0 0.045 13.2 1.2 2.1 1 1 1 2 2 2 0 Not1 N-terminal domain, CCR4-Not complex component zf-HC5HC2H PF13771.6 ELR21462.1 - 0.073 13.3 2.1 0.19 12.0 2.0 1.8 1 1 0 1 1 1 0 PHD-like zinc-binding domain CorA PF01544.18 ELR21462.1 - 0.086 12.1 2.5 0.089 12.1 0.9 1.7 1 1 1 2 2 2 0 CorA-like Mg2+ transporter protein SOGA PF11365.8 ELR21462.1 - 0.24 12.6 3.5 0.15 13.2 1.1 1.8 1 1 1 2 2 2 0 Protein SOGA TelA PF05816.11 ELR21462.1 - 0.48 9.4 7.9 0.56 9.2 3.0 2.0 1 1 1 2 2 2 0 Toxic anion resistance protein (TelA) DASH_Spc19 PF08287.11 ELR21462.1 - 0.66 9.9 6.2 0.1 12.5 1.0 1.9 1 1 1 2 2 2 0 Spc19 FapA PF03961.13 ELR21462.1 - 3.4 6.2 7.0 2.7 6.5 3.9 1.8 1 1 1 2 2 2 0 Flagellar Assembly Protein A CSN5_C PF18323.1 ELR21462.1 - 4.2 8.3 7.6 3.1 8.8 0.4 2.2 2 0 0 2 2 2 0 Cop9 signalosome subunit 5 C-terminal domain DUF5093 PF17011.5 ELR21462.1 - 6.2 7.1 6.4 3.6 7.9 0.3 2.4 1 1 0 2 2 2 0 Domain of unknown function (DUF5093) TauE PF01925.19 ELR21463.1 - 5.6e-27 94.9 37.6 1.5e-14 54.2 8.6 2.5 2 1 0 2 2 2 2 Sulfite exporter TauE/SafE WBS28 PF15164.6 ELR21463.1 - 0.03 13.6 1.5 0.058 12.7 1.5 1.4 1 0 0 1 1 1 0 Williams-Beuren syndrome chromosomal region 28 protein homologue Rrp15p PF07890.12 ELR21463.1 - 0.1 12.9 0.0 0.17 12.2 0.0 1.3 1 0 0 1 1 1 0 Rrp15p DUF1691 PF07950.11 ELR21463.1 - 0.63 10.8 4.2 0.82 10.4 0.2 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF1691) DUF155 PF02582.14 ELR21464.1 - 8.4e-32 110.7 0.0 1.3e-31 110.0 0.0 1.3 1 0 0 1 1 1 1 Uncharacterised ACR, YagE family COG1723 Rootletin PF15035.6 ELR21465.1 - 3.8e-05 23.8 12.8 0.036 14.1 5.8 2.7 3 0 0 3 3 3 2 Ciliary rootlet component, centrosome cohesion MIT PF04212.18 ELR21465.1 - 5.5e-05 23.1 2.7 5.5e-05 23.1 2.7 2.7 3 0 0 3 3 3 1 MIT (microtubule interacting and transport) domain HrpB7 PF09486.10 ELR21465.1 - 8.6e-05 23.0 4.8 8.6e-05 23.0 4.8 2.6 2 0 0 2 2 2 1 Bacterial type III secretion protein (HrpB7) Macoilin PF09726.9 ELR21465.1 - 0.00018 20.3 2.0 0.00018 20.3 2.0 2.4 1 1 1 2 2 1 1 Macoilin family NRBF2_MIT PF17169.4 ELR21465.1 - 0.0074 16.5 1.8 0.0074 16.5 1.8 2.7 2 1 1 3 3 3 1 MIT domain of nuclear receptor-binding factor 2 RPN7 PF10602.9 ELR21465.1 - 0.14 11.8 0.1 0.14 11.8 0.1 2.3 3 0 0 3 3 3 0 26S proteasome subunit RPN7 DUF3450 PF11932.8 ELR21465.1 - 0.64 9.3 14.3 0.83 8.9 0.6 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) BORCS6 PF10157.9 ELR21465.1 - 0.7 10.1 10.3 0.15 12.3 1.3 2.9 2 0 0 2 2 2 0 BLOC-1-related complex sub-unit 6 DUF4407 PF14362.6 ELR21465.1 - 2.1 7.6 11.1 1.1 8.5 3.9 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) YabA PF06156.13 ELR21465.1 - 3.1 8.5 21.4 1.7 9.3 8.2 2.4 2 0 0 2 2 2 0 Initiation control protein YabA HemX PF04375.14 ELR21465.1 - 4.2 6.5 14.3 2.5 7.3 5.1 2.4 2 0 0 2 2 2 0 HemX, putative uroporphyrinogen-III C-methyltransferase GILT PF03227.16 ELR21466.1 - 4.7e-07 30.0 0.0 8.3e-07 29.2 0.0 1.4 1 0 0 1 1 1 1 Gamma interferon inducible lysosomal thiol reductase (GILT) Methyltransf_31 PF13847.6 ELR21467.1 - 9e-26 90.5 0.0 1.4e-25 89.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ELR21467.1 - 8.7e-16 58.4 0.0 1.4e-15 57.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ELR21467.1 - 6.4e-13 49.2 0.0 1.1e-12 48.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ELR21467.1 - 7.9e-10 39.4 0.0 1.4e-09 38.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 ELR21467.1 - 1.5e-08 34.3 0.0 3.5e-08 33.1 0.0 1.5 2 0 0 2 2 2 1 ubiE/COQ5 methyltransferase family Methyltransf_23 PF13489.6 ELR21467.1 - 1.5e-07 31.4 0.0 2.6e-07 30.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 ELR21467.1 - 4.7e-05 23.3 0.0 7.3e-05 22.6 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) ATP-synt_Z PF16594.5 ELR21468.1 - 0.1 12.1 0.1 0.15 11.5 0.1 1.3 1 0 0 1 1 1 0 Putative AtpZ or ATP-synthase-associated Myb_DNA-binding PF00249.31 ELR21469.1 - 5.3e-11 42.5 0.1 1.1e-10 41.5 0.1 1.4 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 ELR21469.1 - 8.4e-06 25.9 0.1 1.8e-05 24.9 0.1 1.5 1 0 0 1 1 1 1 Myb-like DNA-binding domain DUF3543 PF12063.8 ELR21469.1 - 0.0017 17.8 0.7 0.0017 17.8 0.7 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF3543) Myb_DNA-bind_7 PF15963.5 ELR21469.1 - 0.0035 17.2 0.1 0.0094 15.8 0.1 1.7 1 0 0 1 1 1 1 Myb DNA-binding like AAA PF00004.29 ELR21470.1 - 1.1e-42 145.5 0.1 4.6e-42 143.6 0.0 2.1 3 0 0 3 3 2 1 ATPase family associated with various cellular activities (AAA) Prot_ATP_ID_OB PF16450.5 ELR21470.1 - 7.4e-09 35.4 0.0 4.9e-08 32.8 0.0 2.3 2 0 0 2 2 2 1 Proteasomal ATPase OB C-terminal domain AAA_lid_3 PF17862.1 ELR21470.1 - 7.5e-09 35.3 0.0 2e-08 33.9 0.0 1.8 1 0 0 1 1 1 1 AAA+ lid domain AAA_5 PF07728.14 ELR21470.1 - 1.4e-07 31.6 0.1 5e-07 29.8 0.1 2.0 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 ELR21470.1 - 2.9e-06 27.5 0.0 7.3e-06 26.2 0.0 1.7 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_16 PF13191.6 ELR21470.1 - 3.6e-06 27.5 0.6 0.00037 20.9 0.0 2.5 1 1 0 2 2 2 1 AAA ATPase domain DUF815 PF05673.13 ELR21470.1 - 4.1e-05 22.9 0.1 0.00015 21.0 0.0 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF815) AAA_18 PF13238.6 ELR21470.1 - 0.00022 21.8 0.1 0.0058 17.2 0.0 2.6 3 0 0 3 3 3 1 AAA domain TsaE PF02367.17 ELR21470.1 - 0.00026 21.0 0.1 0.034 14.2 0.0 2.5 1 1 1 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_22 PF13401.6 ELR21470.1 - 0.00044 20.5 1.0 0.049 13.9 0.1 2.7 1 1 1 2 2 2 1 AAA domain AAA_28 PF13521.6 ELR21470.1 - 0.0012 19.1 0.0 0.0026 18.0 0.0 1.6 1 0 0 1 1 1 1 AAA domain RuvB_N PF05496.12 ELR21470.1 - 0.0013 18.5 0.0 0.0047 16.7 0.0 1.9 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain TIP49 PF06068.13 ELR21470.1 - 0.0021 17.3 0.0 0.0038 16.5 0.0 1.5 1 0 0 1 1 1 1 TIP49 P-loop domain Sigma54_activat PF00158.26 ELR21470.1 - 0.0025 17.5 0.2 0.13 12.0 0.0 2.9 3 0 0 3 3 3 1 Sigma-54 interaction domain Mg_chelatase PF01078.21 ELR21470.1 - 0.0043 16.5 0.3 0.014 14.8 0.3 1.8 1 1 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_7 PF12775.7 ELR21470.1 - 0.011 15.3 0.1 0.042 13.4 0.1 1.8 1 1 0 1 1 1 0 P-loop containing dynein motor region NTPase_1 PF03266.15 ELR21470.1 - 0.011 15.7 0.0 0.032 14.2 0.0 1.8 2 0 0 2 2 2 0 NTPase RNA_helicase PF00910.22 ELR21470.1 - 0.013 15.9 0.0 0.025 15.0 0.0 1.5 1 0 0 1 1 1 0 RNA helicase IstB_IS21 PF01695.17 ELR21470.1 - 0.016 15.0 0.0 0.04 13.6 0.0 1.6 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_24 PF13479.6 ELR21470.1 - 0.023 14.4 0.2 0.068 12.9 0.2 1.9 1 1 0 1 1 1 0 AAA domain NACHT PF05729.12 ELR21470.1 - 0.024 14.6 0.1 0.093 12.6 0.0 2.0 2 0 0 2 2 2 0 NACHT domain AAA_14 PF13173.6 ELR21470.1 - 0.043 13.8 0.2 0.45 10.5 0.0 2.2 2 0 0 2 2 2 0 AAA domain ATPase PF06745.13 ELR21470.1 - 0.045 13.1 0.8 0.13 11.6 0.0 2.1 3 0 0 3 3 3 0 KaiC AAA_33 PF13671.6 ELR21470.1 - 0.049 13.8 0.0 0.12 12.6 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_3 PF07726.11 ELR21470.1 - 0.081 12.8 0.0 0.18 11.6 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Parvo_NS1 PF01057.17 ELR21470.1 - 0.082 12.0 0.0 0.15 11.1 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 cobW PF02492.19 ELR21470.1 - 0.11 12.1 0.0 0.26 10.9 0.0 1.5 1 1 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA_30 PF13604.6 ELR21470.1 - 0.11 12.2 0.3 0.27 10.9 0.3 1.7 1 1 0 1 1 1 0 AAA domain AAA_25 PF13481.6 ELR21470.1 - 0.16 11.6 3.5 0.091 12.3 0.7 2.0 2 1 0 2 2 2 0 AAA domain AAA_19 PF13245.6 ELR21470.1 - 0.18 12.1 0.2 0.6 10.4 0.1 1.9 2 0 0 2 2 1 0 AAA domain potato_inhibit PF00280.18 ELR21471.1 - 1.4e-16 60.9 0.6 1.6e-16 60.7 0.6 1.0 1 0 0 1 1 1 1 Potato inhibitor I family PASTA PF03793.19 ELR21471.1 - 0.1 12.5 0.3 0.43 10.5 0.2 2.0 1 1 1 2 2 2 0 PASTA domain Inhibitor_I78 PF11720.8 ELR21471.1 - 0.15 12.2 0.0 0.17 12.0 0.0 1.2 1 0 0 1 1 1 0 Peptidase inhibitor I78 family Pkinase PF00069.25 ELR21472.1 - 5.6e-69 232.4 0.0 6.5e-69 232.2 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR21472.1 - 7.9e-36 123.7 0.0 9.9e-36 123.3 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ELR21472.1 - 1.2e-07 31.3 0.0 3.7e-07 29.7 0.0 1.8 2 1 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 ELR21472.1 - 8.9e-05 21.4 0.0 0.00014 20.8 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 ELR21472.1 - 0.00052 19.4 0.0 0.0014 18.0 0.0 1.6 1 1 1 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 ELR21472.1 - 0.00096 18.2 0.0 0.0014 17.7 0.0 1.3 1 0 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 ELR21472.1 - 0.0024 17.8 0.0 0.0075 16.2 0.0 1.7 1 1 1 2 2 2 1 Phosphotransferase enzyme family Y1_Tnp PF01797.16 ELR21472.1 - 0.025 14.7 0.1 0.043 13.9 0.1 1.4 1 0 0 1 1 1 0 Transposase IS200 like Pkinase PF00069.25 ELR21473.1 - 7.3e-60 202.6 0.0 1.6e-59 201.4 0.0 1.6 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR21473.1 - 3.1e-31 108.6 0.0 4.1e-31 108.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase PQQ PF01011.21 ELR21473.1 - 2.5e-20 71.4 1.0 0.0013 18.6 0.0 6.7 6 0 0 6 6 6 6 PQQ enzyme repeat PQQ_2 PF13360.6 ELR21473.1 - 1.5e-15 57.4 8.8 1.8e-07 31.0 0.6 3.5 1 1 0 3 3 3 3 PQQ-like domain Kinase-like PF14531.6 ELR21473.1 - 1.7e-07 30.9 0.0 2.8e-07 30.1 0.0 1.3 1 0 0 1 1 1 1 Kinase-like PQQ_3 PF13570.6 ELR21473.1 - 1e-06 29.1 15.3 2.6 8.7 0.1 7.0 7 0 0 7 7 7 3 PQQ-like domain Kdo PF06293.14 ELR21473.1 - 0.00057 19.3 0.0 0.0012 18.3 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 ELR21473.1 - 0.0023 17.9 0.2 0.0048 16.8 0.2 1.5 1 0 0 1 1 1 1 Phosphotransferase enzyme family ABC1 PF03109.16 ELR21473.1 - 0.005 17.0 0.0 0.01 16.0 0.0 1.4 1 0 0 1 1 1 1 ABC1 family Pkinase_fungal PF17667.1 ELR21473.1 - 0.0063 15.3 0.0 0.0098 14.7 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase YL1 PF05764.13 ELR21473.1 - 3.1 7.9 7.2 4.7 7.3 7.2 1.1 1 0 0 1 1 1 0 YL1 nuclear protein Snf7 PF03357.21 ELR21475.1 - 7.2e-05 22.4 0.8 0.00011 21.9 0.8 1.2 1 0 0 1 1 1 1 Snf7 RhoGEF PF00621.20 ELR21476.1 - 5.6e-40 137.5 0.6 8.2e-40 137.0 0.6 1.3 1 0 0 1 1 1 1 RhoGEF domain PH PF00169.29 ELR21476.1 - 2.3e-05 24.8 0.0 0.064 13.8 0.0 2.7 2 0 0 2 2 2 2 PH domain IQ PF00612.27 ELR21476.1 - 0.0069 16.1 1.3 0.02 14.6 1.3 1.9 1 0 0 1 1 1 1 IQ calmodulin-binding motif PH_13 PF16652.5 ELR21476.1 - 0.0084 15.9 1.5 0.2 11.5 0.0 2.8 3 0 0 3 3 3 1 Pleckstrin homology domain Pkinase PF00069.25 ELR21477.1 - 3.5e-65 220.0 0.0 4.2e-65 219.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR21477.1 - 5.9e-35 120.8 0.0 7.1e-35 120.5 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 ELR21477.1 - 1.7e-05 24.3 0.0 2.7e-05 23.6 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 ELR21477.1 - 0.0028 16.5 0.0 0.0058 15.5 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase IMUP PF15761.5 ELR21477.1 - 0.044 14.5 1.0 0.083 13.6 1.0 1.3 1 0 0 1 1 1 0 Immortalisation up-regulated protein Kinase-like PF14531.6 ELR21477.1 - 0.051 12.9 0.0 0.084 12.2 0.0 1.4 1 0 0 1 1 1 0 Kinase-like RIO1 PF01163.22 ELR21477.1 - 0.053 13.1 0.0 0.075 12.6 0.0 1.3 1 0 0 1 1 1 0 RIO1 family APH PF01636.23 ELR21477.1 - 0.056 13.4 0.0 0.17 11.7 0.0 1.8 1 1 0 1 1 1 0 Phosphotransferase enzyme family Band_7 PF01145.25 ELR21479.1 - 4.4e-24 85.4 0.0 6.6e-24 84.9 0.0 1.2 1 0 0 1 1 1 1 SPFH domain / Band 7 family FragX_IP PF05994.11 ELR21479.1 - 0.072 11.1 0.0 0.094 10.8 0.0 1.2 1 0 0 1 1 1 0 Cytoplasmic Fragile-X interacting family DUF1308 PF07000.11 ELR21479.1 - 0.15 12.0 0.5 0.26 11.2 0.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1308) PhyH PF05721.13 ELR21480.1 - 0.00034 20.9 3.6 0.00064 20.0 0.1 2.9 2 2 0 2 2 2 1 Phytanoyl-CoA dioxygenase (PhyH) Apolipoprotein PF01442.18 ELR21480.1 - 1.8 8.4 28.9 2.7 7.8 28.9 1.2 1 0 0 1 1 1 0 Apolipoprotein A1/A4/E domain Aminotran_1_2 PF00155.21 ELR21480.1 - 3.7 6.6 5.6 1.6 7.9 1.7 1.9 2 0 0 2 2 2 0 Aminotransferase class I and II Prominin PF05478.11 ELR21480.1 - 4.4 5.1 8.0 0.86 7.5 0.4 2.0 1 1 1 2 2 2 0 Prominin Ank_2 PF12796.7 ELR21481.1 - 8.3e-55 183.3 8.7 5.3e-18 65.4 0.4 3.7 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank PF00023.30 ELR21481.1 - 3.6e-39 131.5 7.0 4.8e-07 29.9 0.0 6.5 6 0 0 6 6 6 6 Ankyrin repeat Ank_4 PF13637.6 ELR21481.1 - 1.2e-34 118.2 18.6 3.2e-09 37.1 0.1 5.3 1 1 6 7 7 7 7 Ankyrin repeats (many copies) Ank_3 PF13606.6 ELR21481.1 - 2.6e-30 101.1 5.4 2.6e-05 24.3 0.0 6.6 6 0 0 6 6 6 5 Ankyrin repeat Ank_5 PF13857.6 ELR21481.1 - 4.7e-28 96.9 5.7 2.5e-08 34.0 0.0 5.3 1 1 5 6 6 6 6 Ankyrin repeats (many copies) Filamin PF00630.19 ELR21481.1 - 4e-20 72.6 0.0 6e-13 49.5 0.0 2.8 2 1 0 2 2 2 2 Filamin/ABP280 repeat zf-C3HC4_3 PF13920.6 ELR21481.1 - 7.4e-08 32.1 7.9 1.4e-07 31.3 7.9 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) HAUS2 PF15003.6 ELR21481.1 - 0.0011 18.8 0.4 0.0022 17.8 0.3 1.5 1 1 0 1 1 1 1 HAUS augmin-like complex subunit 2 TMCO5 PF14992.6 ELR21481.1 - 0.041 13.5 5.7 0.066 12.8 5.7 1.2 1 0 0 1 1 1 0 TMCO5 family Prok-RING_4 PF14447.6 ELR21481.1 - 0.12 12.2 9.3 0.16 11.8 7.8 2.0 2 0 0 2 2 2 0 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 ELR21481.1 - 0.12 12.3 8.2 0.27 11.2 8.2 1.6 1 0 0 1 1 1 0 zinc-RING finger domain OmpH PF03938.14 ELR21481.1 - 0.13 12.6 11.6 0.24 11.8 11.6 1.3 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) Cob_adeno_trans PF01923.18 ELR21481.1 - 0.14 12.3 0.7 0.31 11.2 0.7 1.5 1 0 0 1 1 1 0 Cobalamin adenosyltransferase Spc7 PF08317.11 ELR21481.1 - 0.68 8.8 8.4 1.1 8.1 8.4 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF4407 PF14362.6 ELR21481.1 - 0.74 9.1 3.9 1.8 7.8 3.9 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Cnn_1N PF07989.11 ELR21481.1 - 1.3 9.3 6.7 3.1 8.0 6.7 1.7 1 0 0 1 1 1 0 Centrosomin N-terminal motif 1 TPR_MLP1_2 PF07926.12 ELR21481.1 - 1.3 9.1 13.7 2.5 8.2 3.5 2.4 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein Taxilin PF09728.9 ELR21481.1 - 1.8 7.7 13.2 2.6 7.1 13.2 1.2 1 0 0 1 1 1 0 Myosin-like coiled-coil protein Seryl_tRNA_N PF02403.22 ELR21481.1 - 2.3 8.5 8.1 6.6 7.0 8.1 1.8 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain Tropomyosin_1 PF12718.7 ELR21481.1 - 4.5 7.4 13.0 13 6.0 13.1 1.6 1 1 0 1 1 1 0 Tropomyosin like JIP_LZII PF16471.5 ELR21481.1 - 9.4 6.5 6.8 73 3.6 6.8 2.4 1 1 0 1 1 1 0 JNK-interacting protein leucine zipper II CK2S PF15011.6 ELR21482.1 - 0.29 11.0 2.9 0.49 10.3 0.4 2.4 3 0 0 3 3 3 0 Casein Kinase 2 substrate IBN_N PF03810.19 ELR21483.1 - 3.6e-15 55.6 0.0 2.4e-14 53.0 0.0 2.5 2 0 0 2 2 2 1 Importin-beta N-terminal domain Cse1 PF08506.10 ELR21483.1 - 3.1e-07 29.6 0.0 7.6e-05 21.7 0.0 2.5 2 0 0 2 2 2 2 Cse1 RIX1 PF08167.12 ELR21483.1 - 0.00023 21.0 0.5 0.18 11.5 0.1 3.8 3 1 1 4 4 4 1 rRNA processing/ribosome biogenesis Xpo1 PF08389.12 ELR21483.1 - 0.12 12.5 0.0 0.83 9.7 0.0 2.7 1 1 0 1 1 1 0 Exportin 1-like protein HEAT PF02985.22 ELR21483.1 - 0.7 10.3 11.4 2.1 8.9 0.0 6.2 7 0 0 7 7 7 0 HEAT repeat HEAT_EZ PF13513.6 ELR21483.1 - 1.6 9.3 13.8 32 5.2 0.3 6.9 7 0 0 7 7 7 0 HEAT-like repeat ABC_tran PF00005.27 ELR21484.1 - 1.4e-23 83.9 0.0 2.2e-23 83.3 0.0 1.3 1 0 0 1 1 1 1 ABC transporter ABC2_membrane PF01061.24 ELR21484.1 - 7.2e-18 64.8 5.2 1e-17 64.3 5.2 1.2 1 0 0 1 1 1 1 ABC-2 type transporter RsgA_GTPase PF03193.16 ELR21484.1 - 0.0017 18.3 0.0 0.0034 17.3 0.0 1.4 1 0 0 1 1 1 1 RsgA GTPase AAA_29 PF13555.6 ELR21484.1 - 0.013 15.2 0.1 0.031 14.0 0.1 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_21 PF13304.6 ELR21484.1 - 0.017 15.0 0.1 7.4 6.3 0.0 2.3 2 0 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_22 PF13401.6 ELR21484.1 - 0.026 14.8 0.0 0.071 13.4 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.6 ELR21484.1 - 0.028 14.0 0.7 0.063 12.8 0.7 1.5 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 ELR21484.1 - 0.036 14.4 0.0 0.08 13.3 0.0 1.7 1 0 0 1 1 1 0 AAA ATPase domain MMR_HSR1 PF01926.23 ELR21484.1 - 0.18 11.9 0.0 0.52 10.4 0.0 1.8 1 1 0 1 1 1 0 50S ribosome-binding GTPase DEAD PF00270.29 ELR21485.1 - 2e-13 50.5 0.0 3.6e-13 49.7 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ELR21485.1 - 3.1e-05 24.3 0.0 5.2e-05 23.6 0.0 1.4 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Homeodomain PF00046.29 ELR21486.1 - 2.5e-13 49.7 0.5 2.5e-13 49.7 0.5 1.5 2 0 0 2 2 2 1 Homeodomain Homeobox_KN PF05920.11 ELR21486.1 - 1e-06 28.5 0.3 1.9e-06 27.7 0.3 1.5 1 0 0 1 1 1 1 Homeobox KN domain Sgf11 PF08209.11 ELR21487.1 - 3.9e-16 58.3 0.5 6.8e-16 57.5 0.5 1.3 1 0 0 1 1 1 1 Sgf11 (transcriptional regulation protein) IATP PF04568.12 ELR21487.1 - 0.083 13.3 0.0 0.083 13.3 0.0 3.0 3 0 0 3 3 3 0 Mitochondrial ATPase inhibitor, IATP zf-C2HC_2 PF13913.6 ELR21487.1 - 0.11 12.4 0.3 0.19 11.7 0.3 1.3 1 0 0 1 1 1 0 zinc-finger of a C2HC-type PBP1_TM PF14812.6 ELR21487.1 - 3.4 8.1 5.8 2 8.8 0.5 2.8 3 0 0 3 3 3 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Tubulin PF00091.25 ELR21488.1 - 5e-66 222.6 0.0 9.3e-66 221.8 0.0 1.4 2 0 0 2 2 2 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 ELR21488.1 - 6.4e-40 136.2 0.0 1.1e-39 135.5 0.0 1.4 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.6 ELR21488.1 - 0.00034 20.3 0.0 0.00058 19.6 0.0 1.3 1 0 0 1 1 1 1 Tubulin domain ABC2_membrane PF01061.24 ELR21489.1 - 1.5e-30 106.2 11.8 1.5e-30 106.2 11.8 2.1 1 1 1 2 2 2 1 ABC-2 type transporter ABC_tran PF00005.27 ELR21489.1 - 4.5e-27 95.2 0.7 7e-27 94.6 0.0 1.6 2 0 0 2 2 1 1 ABC transporter AAA_25 PF13481.6 ELR21489.1 - 1.1e-05 25.1 2.1 1.8e-05 24.4 0.1 2.2 3 0 0 3 3 3 1 AAA domain T2SSE PF00437.20 ELR21489.1 - 1.9e-05 23.8 1.5 0.0014 17.7 0.4 2.3 2 0 0 2 2 2 1 Type II/IV secretion system protein AAA_16 PF13191.6 ELR21489.1 - 0.00037 20.9 0.0 0.00098 19.5 0.0 1.7 1 0 0 1 1 1 1 AAA ATPase domain AAA_30 PF13604.6 ELR21489.1 - 0.0015 18.3 0.1 0.0027 17.4 0.1 1.4 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 ELR21489.1 - 0.0032 18.0 0.0 0.011 16.3 0.0 1.9 2 0 0 2 2 2 1 AAA domain ABC2_membrane_3 PF12698.7 ELR21489.1 - 0.0039 16.3 14.5 0.0039 16.3 14.5 1.6 2 0 0 2 2 2 1 ABC-2 family transporter protein NACHT PF05729.12 ELR21489.1 - 0.0049 16.8 0.5 0.013 15.4 0.1 2.0 2 1 0 2 2 1 1 NACHT domain SMC_N PF02463.19 ELR21489.1 - 0.012 15.1 0.0 0.025 14.0 0.0 1.4 1 0 0 1 1 1 0 RecF/RecN/SMC N terminal domain RsgA_GTPase PF03193.16 ELR21489.1 - 0.013 15.4 0.4 0.028 14.3 0.4 1.5 1 0 0 1 1 1 0 RsgA GTPase AAA_21 PF13304.6 ELR21489.1 - 0.014 15.2 0.2 1.1 9.0 0.4 2.4 2 0 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 ELR21489.1 - 0.015 15.8 0.5 0.015 15.8 0.5 2.1 2 0 0 2 2 2 0 AAA domain DUF87 PF01935.17 ELR21489.1 - 0.03 14.4 0.6 0.06 13.4 0.6 1.4 1 0 0 1 1 1 0 Helicase HerA, central domain AAA_5 PF07728.14 ELR21489.1 - 0.034 14.2 0.0 0.076 13.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) Rad17 PF03215.15 ELR21489.1 - 0.035 14.0 0.0 0.061 13.2 0.0 1.3 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_22 PF13401.6 ELR21489.1 - 0.038 14.3 0.0 0.1 12.9 0.0 1.7 1 0 0 1 1 1 0 AAA domain cobW PF02492.19 ELR21489.1 - 0.039 13.6 0.1 0.12 12.0 0.1 1.9 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA_29 PF13555.6 ELR21489.1 - 0.039 13.7 0.3 0.096 12.4 0.3 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain MMR_HSR1 PF01926.23 ELR21489.1 - 0.041 14.0 0.3 0.1 12.7 0.3 1.7 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_19 PF13245.6 ELR21489.1 - 0.041 14.2 0.4 0.092 13.1 0.2 1.4 1 1 0 1 1 1 0 AAA domain AAA_28 PF13521.6 ELR21489.1 - 0.045 14.0 0.4 0.12 12.6 0.4 1.7 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 ELR21489.1 - 0.073 13.2 0.0 0.19 11.9 0.0 1.8 1 0 0 1 1 1 0 AAA domain dNK PF01712.19 ELR21489.1 - 0.11 12.3 0.0 0.18 11.6 0.0 1.3 1 0 0 1 1 1 0 Deoxynucleoside kinase RNA_helicase PF00910.22 ELR21489.1 - 0.17 12.3 0.0 0.38 11.1 0.0 1.7 1 0 0 1 1 1 0 RNA helicase DUF2207 PF09972.9 ELR21489.1 - 1.3 7.7 9.7 57 2.3 9.7 2.1 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF2070 PF09843.9 ELR21489.1 - 2.3 6.4 8.3 3.3 5.9 8.3 1.3 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) Zn_clus PF00172.18 ELR21490.1 - 4.7e-07 29.8 6.7 7.4e-07 29.2 6.7 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF1839 PF08893.10 ELR21490.1 - 0.065 12.4 0.0 0.093 11.9 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1839) Gal_Lectin PF02140.18 ELR21491.1 - 4.4e-29 100.7 4.6 4.1e-14 52.8 0.4 2.1 2 0 0 2 2 2 2 Galactose binding lectin domain DUF902 PF06001.13 ELR21491.1 - 0.18 12.3 2.4 7.5 7.1 0.1 3.3 3 0 0 3 3 3 0 Domain of Unknown Function (DUF902) TAF8_C PF10406.9 ELR21491.1 - 0.22 12.1 0.8 0.37 11.4 0.8 1.3 1 0 0 1 1 1 0 Transcription factor TFIID complex subunit 8 C-term PAS_3 PF08447.12 ELR21492.1 - 0.052 13.8 0.0 0.088 13.1 0.0 1.4 1 0 0 1 1 1 0 PAS fold PAS_9 PF13426.7 ELR21492.1 - 0.11 12.8 0.0 0.17 12.1 0.0 1.3 1 0 0 1 1 1 0 PAS domain PAS PF00989.25 ELR21492.1 - 0.14 12.2 0.0 0.4 10.7 0.0 1.8 1 1 0 1 1 1 0 PAS fold ABC2_membrane PF01061.24 ELR21493.1 - 1.8e-36 125.5 17.7 2.7e-36 125.0 17.7 1.3 1 0 0 1 1 1 1 ABC-2 type transporter ABC_tran PF00005.27 ELR21493.1 - 2e-27 96.4 0.0 3.3e-27 95.7 0.0 1.3 1 0 0 1 1 1 1 ABC transporter ABC2_membrane_3 PF12698.7 ELR21493.1 - 2.9e-06 26.7 12.6 2.9e-06 26.7 12.6 1.7 1 1 0 1 1 1 1 ABC-2 family transporter protein AAA_25 PF13481.6 ELR21493.1 - 8.9e-06 25.4 0.1 1.5e-05 24.7 0.1 1.3 1 0 0 1 1 1 1 AAA domain T2SSE PF00437.20 ELR21493.1 - 1.3e-05 24.4 2.0 0.00065 18.8 0.5 2.2 2 0 0 2 2 2 1 Type II/IV secretion system protein AAA_16 PF13191.6 ELR21493.1 - 0.0003 21.2 0.0 0.0006 20.2 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain AAA_30 PF13604.6 ELR21493.1 - 0.0037 17.0 0.1 0.006 16.3 0.1 1.3 1 0 0 1 1 1 1 AAA domain AAA_21 PF13304.6 ELR21493.1 - 0.0058 16.5 0.1 0.98 9.2 0.1 2.5 3 0 0 3 3 3 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_18 PF13238.6 ELR21493.1 - 0.006 17.1 0.0 0.011 16.3 0.0 1.4 1 0 0 1 1 1 1 AAA domain RsgA_GTPase PF03193.16 ELR21493.1 - 0.0082 16.1 0.2 0.017 15.0 0.2 1.5 1 0 0 1 1 1 1 RsgA GTPase AAA_23 PF13476.6 ELR21493.1 - 0.0087 16.6 0.3 0.017 15.7 0.3 1.3 1 0 0 1 1 1 1 AAA domain NACHT PF05729.12 ELR21493.1 - 0.0091 15.9 0.2 0.029 14.3 0.2 1.8 1 1 0 1 1 1 1 NACHT domain SMC_N PF02463.19 ELR21493.1 - 0.016 14.6 0.0 0.033 13.6 0.0 1.4 1 0 0 1 1 1 0 RecF/RecN/SMC N terminal domain Rad17 PF03215.15 ELR21493.1 - 0.019 14.9 0.0 0.035 14.0 0.0 1.3 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_5 PF07728.14 ELR21493.1 - 0.022 14.8 0.1 0.054 13.5 0.1 1.6 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_29 PF13555.6 ELR21493.1 - 0.027 14.2 0.1 0.062 13.0 0.1 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain DUF87 PF01935.17 ELR21493.1 - 0.035 14.2 0.6 0.059 13.5 0.6 1.3 1 0 0 1 1 1 0 Helicase HerA, central domain AAA_22 PF13401.6 ELR21493.1 - 0.037 14.3 0.0 0.069 13.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain MMR_HSR1 PF01926.23 ELR21493.1 - 0.038 14.1 0.2 0.087 12.9 0.2 1.6 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_28 PF13521.6 ELR21493.1 - 0.066 13.5 0.6 0.13 12.4 0.6 1.5 1 0 0 1 1 1 0 AAA domain cobW PF02492.19 ELR21493.1 - 0.073 12.6 0.3 0.15 11.6 0.3 1.5 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA_33 PF13671.6 ELR21493.1 - 0.096 12.8 0.0 0.31 11.2 0.0 1.9 2 0 0 2 2 1 0 AAA domain dNK PF01712.19 ELR21493.1 - 0.12 12.2 0.0 0.19 11.6 0.0 1.3 1 0 0 1 1 1 0 Deoxynucleoside kinase AAA_19 PF13245.6 ELR21493.1 - 0.14 12.5 0.4 0.26 11.6 0.4 1.4 1 1 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 ELR21493.1 - 0.17 12.3 0.0 0.34 11.3 0.0 1.5 1 0 0 1 1 1 0 RNA helicase F-box-like PF12937.7 ELR21494.1 - 0.038 13.9 0.3 0.077 12.9 0.3 1.5 1 0 0 1 1 1 0 F-box-like Peptidase_C1 PF00112.23 ELR21495.1 - 1.3e-65 221.6 2.4 1.9e-65 221.0 2.4 1.2 1 0 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.12 ELR21495.1 - 8.3e-12 45.4 1.2 1.8e-11 44.3 1.2 1.6 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Nucleoside_tran PF01733.18 ELR21496.1 - 2.3e-58 198.0 13.7 3.7e-58 197.3 13.7 1.3 1 0 0 1 1 1 1 Nucleoside transporter CLN3 PF02487.17 ELR21496.1 - 1.6e-07 30.8 12.6 3.7e-07 29.5 12.6 1.5 1 1 0 1 1 1 1 CLN3 protein MFS_1 PF07690.16 ELR21496.1 - 0.0048 15.9 40.3 0.025 13.5 39.8 1.9 1 1 0 1 1 1 1 Major Facilitator Superfamily HNOB PF07700.15 ELR21497.1 - 2.2e-41 141.5 0.0 4.9e-41 140.4 0.0 1.6 2 0 0 2 2 2 1 Haem-NO-binding HNOBA PF07701.14 ELR21497.1 - 2.7e-19 69.5 0.0 1.6e-11 44.0 0.0 2.4 2 1 0 2 2 2 2 Heme NO binding associated TFIIA PF03153.13 ELR21497.1 - 0.099 12.6 4.4 0.15 12.1 4.4 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Ndc1_Nup PF09531.10 ELR21497.1 - 2.5 6.7 6.7 3.5 6.2 6.7 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup 3Beta_HSD PF01073.19 ELR21498.1 - 4.1e-60 203.2 0.0 4.9e-60 202.9 0.0 1.0 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 ELR21498.1 - 8.5e-32 110.5 0.0 1.1e-31 110.2 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 ELR21498.1 - 2.9e-17 63.1 0.0 5.4e-16 58.9 0.0 2.0 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase NAD_binding_10 PF13460.6 ELR21498.1 - 1e-15 58.1 0.0 1.6e-15 57.5 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding NAD_binding_4 PF07993.12 ELR21498.1 - 1.8e-14 53.5 0.0 6.1e-12 45.2 0.0 2.2 1 1 0 1 1 1 1 Male sterility protein Polysacc_synt_2 PF02719.15 ELR21498.1 - 3.8e-12 45.9 0.0 8.4e-11 41.5 0.0 2.1 2 0 0 2 2 2 1 Polysaccharide biosynthesis protein RmlD_sub_bind PF04321.17 ELR21498.1 - 1.6e-09 37.3 0.0 2.1e-09 36.9 0.0 1.1 1 0 0 1 1 1 1 RmlD substrate binding domain NmrA PF05368.13 ELR21498.1 - 4.4e-06 26.4 0.0 7e-06 25.8 0.0 1.3 1 0 0 1 1 1 1 NmrA-like family KR PF08659.10 ELR21498.1 - 2.3e-05 24.4 0.2 0.00035 20.5 0.2 2.2 1 1 0 1 1 1 1 KR domain ADH_zinc_N PF00107.26 ELR21499.1 - 1.5e-20 73.5 0.0 2.7e-20 72.7 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 ELR21499.1 - 3.5e-11 42.9 0.1 1.7e-10 40.7 0.1 1.8 1 1 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.6 ELR21499.1 - 1.2e-08 36.1 0.1 5.5e-07 30.7 0.1 2.5 1 1 0 1 1 1 1 Zinc-binding dehydrogenase HEPN_Toprim_N PF18871.1 ELR21499.1 - 0.14 12.1 0.0 0.24 11.3 0.0 1.4 1 0 0 1 1 1 0 HEPN/Toprim N-terminal domain 1 Ribosomal_L25p PF01386.19 ELR21500.1 - 0.13 12.8 0.0 0.23 12.0 0.0 1.4 1 0 0 1 1 1 0 Ribosomal L25p family Glyco_hydro_16 PF00722.21 ELR21502.1 - 9e-06 25.3 0.0 1.8e-05 24.3 0.0 1.5 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 Glyco_hydro_42 PF02449.15 ELR21502.1 - 5.7e-05 22.6 0.0 8.6e-05 22.0 0.0 1.2 1 0 0 1 1 1 1 Beta-galactosidase EGF_2 PF07974.13 ELR21502.1 - 0.00049 20.4 18.8 0.00092 19.5 18.8 1.5 1 0 0 1 1 1 1 EGF-like domain EGF_Tenascin PF18720.1 ELR21502.1 - 2 8.6 9.6 4 7.6 9.6 1.5 1 0 0 1 1 1 0 Tenascin EGF domain PARP PF00644.20 ELR21503.1 - 6.5e-10 38.9 0.0 1.5e-09 37.8 0.0 1.6 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain CCDC50_N PF15295.6 ELR21503.1 - 7.1 6.8 26.8 7.2 6.8 11.1 3.2 1 1 1 2 2 2 0 Coiled-coil domain-containing protein 50 N-terminus Dabb PF07876.12 ELR21504.1 - 0.06 14.0 0.2 0.067 13.8 0.2 1.2 1 1 0 1 1 1 0 Stress responsive A/B Barrel Domain LCAT PF02450.15 ELR21505.1 - 2e-57 195.1 0.0 4.1e-56 190.8 0.0 2.5 1 1 0 1 1 1 1 Lecithin:cholesterol acyltransferase C2 PF00168.30 ELR21505.1 - 2.7e-29 101.5 0.2 3.4e-13 49.8 0.0 2.4 2 0 0 2 2 2 2 C2 domain PX PF00787.24 ELR21505.1 - 5.2e-07 29.6 0.4 1.4e-06 28.2 0.4 1.7 1 0 0 1 1 1 1 PX domain DUF676 PF05057.14 ELR21505.1 - 0.0027 17.2 0.0 0.0065 16.0 0.0 1.6 1 0 0 1 1 1 1 Putative serine esterase (DUF676) DUF726 PF05277.12 ELR21505.1 - 0.013 14.5 0.0 0.021 13.8 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF726) SMN PF06003.12 ELR21505.1 - 0.025 13.8 0.4 0.048 12.9 0.4 1.4 1 0 0 1 1 1 0 Survival motor neuron protein (SMN) Abhydrolase_6 PF12697.7 ELR21505.1 - 0.1 13.2 0.1 0.2 12.2 0.1 1.5 1 0 0 1 1 1 0 Alpha/beta hydrolase family PGAP1 PF07819.13 ELR21505.1 - 0.13 11.9 0.0 0.28 10.9 0.0 1.5 1 0 0 1 1 1 0 PGAP1-like protein Usp PF00582.26 ELR21506.1 - 1.1e-05 26.0 0.0 3.6e-05 24.3 0.0 1.8 1 1 0 1 1 1 1 Universal stress protein family NDUF_B7 PF05676.13 ELR21507.1 - 6e-05 22.7 2.1 8e-05 22.3 2.1 1.2 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) CHCH PF06747.13 ELR21507.1 - 0.012 15.7 4.7 0.022 14.9 3.5 2.0 1 1 1 2 2 2 0 CHCH domain Mito_carr PF00153.27 ELR21509.1 - 7.8e-05 22.5 0.1 0.00022 21.1 0.1 1.7 1 0 0 1 1 1 1 Mitochondrial carrier protein META PF03724.16 ELR21510.1 - 0.0015 18.5 0.0 0.0022 17.9 0.0 1.2 1 0 0 1 1 1 1 META domain Ras PF00071.22 ELR21511.1 - 6.6e-61 204.6 2.5 7.6e-61 204.4 2.5 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR21511.1 - 7.6e-38 129.4 0.5 1.2e-37 128.8 0.5 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR21511.1 - 8.8e-14 51.3 0.2 1.2e-13 50.8 0.2 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 ELR21511.1 - 9.1e-08 32.2 0.1 1.6e-07 31.4 0.1 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 ELR21511.1 - 0.00014 21.5 0.6 0.00033 20.3 0.6 1.6 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Septin PF00735.18 ELR21511.1 - 0.0002 20.8 0.6 0.0004 19.7 0.1 1.6 2 0 0 2 2 2 1 Septin Gtr1_RagA PF04670.12 ELR21511.1 - 0.00032 20.1 0.8 0.00062 19.2 0.8 1.5 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 ELR21511.1 - 0.00061 19.7 2.5 0.12 12.2 0.3 2.3 1 1 0 2 2 2 2 RsgA GTPase AAA_24 PF13479.6 ELR21511.1 - 0.0042 16.8 0.2 0.0073 16.0 0.1 1.6 2 0 0 2 2 2 1 AAA domain PRK PF00485.18 ELR21511.1 - 0.013 15.2 1.1 0.039 13.7 0.5 1.9 1 1 1 2 2 2 0 Phosphoribulokinase / Uridine kinase family RNA_helicase PF00910.22 ELR21511.1 - 0.014 15.8 0.1 0.038 14.4 0.1 2.0 1 1 0 1 1 1 0 RNA helicase AAA_7 PF12775.7 ELR21511.1 - 0.014 14.9 0.2 0.024 14.2 0.2 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region TniB PF05621.11 ELR21511.1 - 0.016 14.6 0.0 0.026 14.0 0.0 1.3 1 0 0 1 1 1 0 Bacterial TniB protein AAA_30 PF13604.6 ELR21511.1 - 0.017 14.9 0.0 0.02 14.6 0.0 1.2 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 ELR21511.1 - 0.022 15.0 0.0 0.047 14.0 0.0 1.7 1 1 0 1 1 1 0 AAA domain AAA_16 PF13191.6 ELR21511.1 - 0.025 15.0 0.0 0.046 14.1 0.0 1.5 1 1 0 1 1 1 0 AAA ATPase domain ABC_tran PF00005.27 ELR21511.1 - 0.053 14.0 0.2 0.09 13.3 0.2 1.6 1 1 0 1 1 1 0 ABC transporter DUF87 PF01935.17 ELR21511.1 - 0.19 11.8 1.3 1.5 8.8 0.2 2.1 2 0 0 2 2 2 0 Helicase HerA, central domain Folate_rec PF03024.14 ELR21512.1 - 2.4e-15 56.8 18.1 7.1e-11 42.3 8.1 2.2 2 0 0 2 2 2 2 Folate receptor family Filamin PF00630.19 ELR21512.1 - 1.6e-14 54.6 0.0 2.9e-14 53.7 0.0 1.4 1 0 0 1 1 1 1 Filamin/ABP280 repeat NPC1_N PF16414.5 ELR21512.1 - 0.0016 18.0 1.2 0.0016 18.0 1.2 2.2 2 0 0 2 2 2 1 Niemann-Pick C1 N terminus YtkA PF13115.6 ELR21512.1 - 0.037 14.6 0.0 0.074 13.7 0.0 1.5 1 0 0 1 1 1 0 YtkA-like Epimerase PF01370.21 ELR21513.1 - 5.7e-05 22.7 0.0 0.00021 20.9 0.0 1.9 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family RNA_pol_N PF01194.17 ELR21515.1 - 0.052 13.9 0.0 0.12 12.7 0.0 1.6 1 0 0 1 1 1 0 RNA polymerases N / 8 kDa subunit Peptidase_C1 PF00112.23 ELR21516.1 - 1.5e-55 188.7 0.1 2e-55 188.3 0.1 1.1 1 0 0 1 1 1 1 Papain family cysteine protease p450 PF00067.22 ELR21516.1 - 2.2e-13 49.8 0.1 3.3e-06 26.1 0.0 3.1 2 1 1 3 3 3 3 Cytochrome P450 rve PF00665.26 ELR21518.1 - 0.00026 21.2 0.0 0.00026 21.2 0.0 1.1 1 0 0 1 1 1 1 Integrase core domain RVT_2 PF07727.14 ELR21519.1 - 2.5e-56 191.0 0.4 2.4e-55 187.8 0.4 2.1 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_1 PF00078.27 ELR21519.1 - 0.0032 17.0 0.1 0.0069 15.9 0.1 1.6 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF1158 PF06643.11 ELR21519.1 - 0.085 13.4 2.7 4.4 7.9 0.0 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF1158) Nramp PF01566.18 ELR21524.1 - 5.2e-126 420.4 18.7 5.2e-126 420.4 18.7 1.7 2 0 0 2 2 2 1 Natural resistance-associated macrophage protein Tfb2 PF03849.14 ELR21525.1 - 1.3e-98 330.2 0.0 1.7e-98 329.9 0.0 1.1 1 0 0 1 1 1 1 Transcription factor Tfb2 Tfb2_C PF18307.1 ELR21525.1 - 4.6e-20 71.8 0.1 9.4e-20 70.8 0.1 1.6 1 0 0 1 1 1 1 Transcription factor Tfb2 (p52) C-terminal domain SinI PF08671.10 ELR21525.1 - 0.061 13.1 0.0 0.17 11.7 0.0 1.8 1 0 0 1 1 1 0 Anti-repressor SinI ANT PF03374.14 ELR21525.1 - 0.16 12.3 0.0 0.46 10.8 0.0 1.7 1 0 0 1 1 1 0 Phage antirepressor protein KilAC domain LNP1 PF15419.6 ELR21526.1 - 0.0037 17.5 4.9 0.0052 17.0 4.9 1.2 1 0 0 1 1 1 1 Leukemia NUP98 fusion partner 1 COesterase PF00135.28 ELR21527.1 - 6.3e-109 365.2 0.0 1.1e-108 364.3 0.0 1.3 1 1 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 ELR21527.1 - 8.2e-05 22.6 0.1 0.00019 21.3 0.1 1.6 1 1 0 1 1 1 1 alpha/beta hydrolase fold LicD PF04991.13 ELR21528.1 - 4.3e-09 36.8 0.0 1.8e-08 34.8 0.0 1.8 2 0 0 2 2 2 1 LicD family TPK_catalytic PF04263.16 ELR21529.1 - 2.9e-34 117.7 0.0 4.5e-34 117.1 0.0 1.3 1 0 0 1 1 1 1 Thiamin pyrophosphokinase, catalytic domain TPK_B1_binding PF04265.14 ELR21529.1 - 2.9e-17 62.1 0.0 4.7e-17 61.5 0.0 1.4 1 0 0 1 1 1 1 Thiamin pyrophosphokinase, vitamin B1 binding domain EF-hand_1 PF00036.32 ELR21530.1 - 2.6e-24 82.9 9.3 2.2e-06 26.8 0.5 4.8 4 0 0 4 4 4 4 EF hand EF-hand_5 PF13202.6 ELR21530.1 - 1.1e-21 75.3 15.5 1e-07 31.1 0.9 5.1 5 0 0 5 5 5 3 EF hand EF-hand_6 PF13405.6 ELR21530.1 - 1.1e-20 71.7 13.1 1.8e-05 24.3 0.4 4.9 5 0 0 5 5 5 4 EF-hand domain EF-hand_7 PF13499.6 ELR21530.1 - 2.8e-18 66.1 17.4 1.2e-08 35.2 3.1 3.5 2 1 2 4 4 4 4 EF-hand domain pair EF-hand_8 PF13833.6 ELR21530.1 - 1.2e-11 44.3 6.5 0.0049 16.7 0.1 4.4 4 0 0 4 4 4 3 EF-hand domain pair SPARC_Ca_bdg PF10591.9 ELR21530.1 - 0.00013 22.3 1.5 0.072 13.4 0.2 2.7 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 ELR21530.1 - 0.05 13.6 4.6 6.8 6.7 0.0 3.8 1 1 2 4 4 4 0 Cytoskeletal-regulatory complex EF hand Colicin_immun PF09204.10 ELR21530.1 - 0.063 13.8 0.1 0.14 12.7 0.1 1.6 1 0 0 1 1 1 0 Bacterial self-protective colicin-like immunity Dockerin_1 PF00404.18 ELR21530.1 - 0.081 13.1 0.0 9.5 6.5 0.0 2.5 3 0 0 3 3 3 0 Dockerin type I domain DUF945 PF06097.11 ELR21530.1 - 0.081 12.0 0.0 0.1 11.7 0.0 1.1 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF945) CUE PF02845.16 ELR21530.1 - 0.11 12.3 0.0 4.3 7.1 0.0 2.4 2 0 0 2 2 2 0 CUE domain EF-hand_10 PF14788.6 ELR21530.1 - 0.13 12.1 5.8 44 4.0 0.2 4.7 5 0 0 5 5 5 0 EF hand 5_nucleotid PF05761.14 ELR21531.1 - 1.1e-15 57.5 7.3 3.1e-14 52.8 7.3 2.0 1 1 0 1 1 1 1 5' nucleotidase family 5_nucleotid PF05761.14 ELR21532.1 - 2e-110 369.8 4.0 2.5e-92 310.2 0.0 2.8 1 1 1 2 2 2 2 5' nucleotidase family zf-C3HC4_3 PF13920.6 ELR21533.1 - 0.0005 19.9 13.7 0.0005 19.9 13.7 4.2 3 2 1 4 4 4 1 Zinc finger, C3HC4 type (RING finger) SUIM_assoc PF16619.5 ELR21533.1 - 0.00075 19.5 0.0 0.28 11.3 0.0 3.7 3 1 0 3 3 3 1 Unstructured region C-term to UIM in Ataxin3 RR_TM4-6 PF06459.12 ELR21533.1 - 8.5 6.1 12.5 7.4 6.3 2.3 2.5 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 CsbD PF05532.12 ELR21534.1 - 1.8e-05 24.5 7.7 2e-05 24.4 4.2 2.7 3 0 0 3 3 3 1 CsbD-like F-box-like PF12937.7 ELR21535.1 - 1.7e-09 37.5 1.3 4.3e-09 36.1 1.3 1.8 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ELR21535.1 - 1.1e-06 28.4 1.3 2.2e-06 27.4 0.2 2.1 2 0 0 2 2 2 1 F-box domain LRR_8 PF13855.6 ELR21535.1 - 0.0048 16.6 2.1 0.21 11.4 0.2 2.8 2 1 0 2 2 2 1 Leucine rich repeat LRR_1 PF00560.33 ELR21535.1 - 0.019 15.5 5.4 50 5.0 0.0 4.6 4 1 0 4 4 4 0 Leucine Rich Repeat LRR_4 PF12799.7 ELR21535.1 - 0.03 14.7 4.5 0.075 13.5 0.3 2.9 1 1 2 3 3 3 0 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 ELR21535.1 - 0.047 13.8 5.4 2.7 8.3 0.1 4.2 4 0 0 4 4 4 0 Leucine Rich repeat Arm PF00514.23 ELR21536.1 - 4e-18 64.8 8.4 0.0054 16.7 0.0 6.9 7 0 0 7 7 7 6 Armadillo/beta-catenin-like repeat Atx10homo_assoc PF09759.9 ELR21536.1 - 7.9e-08 32.2 4.0 0.07 13.2 0.0 5.6 1 1 5 6 6 6 2 Spinocerebellar ataxia type 10 protein domain Arm_2 PF04826.13 ELR21536.1 - 2.3e-06 27.3 0.5 0.018 14.5 0.0 2.4 1 1 1 2 2 2 2 Armadillo-like V-ATPase_H_N PF03224.14 ELR21536.1 - 5.9e-05 22.5 0.1 0.68 9.2 0.0 2.9 1 1 2 3 3 3 2 V-ATPase subunit H DUF3361 PF11841.8 ELR21536.1 - 0.0014 18.6 0.7 0.46 10.4 0.0 3.2 2 1 0 3 3 3 1 Domain of unknown function (DUF3361) Med26 PF08711.11 ELR21536.1 - 0.029 14.4 3.6 2.3 8.3 0.0 3.8 5 0 0 5 5 5 0 TFIIS helical bundle-like domain HEAT_EZ PF13513.6 ELR21536.1 - 0.037 14.5 8.4 2.1 9.0 0.1 4.8 3 2 3 6 6 6 0 HEAT-like repeat HEAT_2 PF13646.6 ELR21536.1 - 0.042 14.2 13.1 0.21 12.0 0.8 4.2 3 2 1 5 5 5 0 HEAT repeats HEAT PF02985.22 ELR21536.1 - 0.17 12.2 9.7 14 6.3 0.1 5.3 5 0 0 5 5 5 0 HEAT repeat zf-C3HC4_3 PF13920.6 ELR21538.1 - 1.4e-15 56.9 11.6 1.7e-15 56.6 11.6 1.1 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 ELR21538.1 - 2.6e-05 24.0 12.0 3.8e-05 23.5 12.0 1.2 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4 PF00097.25 ELR21538.1 - 4.8e-05 23.1 9.9 0.00011 22.0 10.2 1.5 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ELR21538.1 - 0.00039 20.3 12.7 0.00055 19.8 12.7 1.2 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_2 PF13639.6 ELR21538.1 - 0.0028 18.0 13.4 0.0044 17.3 13.4 1.3 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 ELR21538.1 - 0.062 13.2 13.2 0.1 12.5 13.2 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 ELR21538.1 - 0.19 11.8 10.9 0.36 10.9 4.7 2.3 2 0 0 2 2 2 0 RING-type zinc-finger zf-C3HC4_4 PF15227.6 ELR21538.1 - 3.9 7.7 11.7 0.43 10.8 4.1 2.3 2 0 0 2 2 2 0 zinc finger of C3HC4-type, RING Lyase_aromatic PF00221.19 ELR21539.1 - 2.5e-189 629.8 0.6 2.9e-189 629.6 0.6 1.0 1 0 0 1 1 1 1 Aromatic amino acid lyase Cnl2_NKP2 PF09447.10 ELR21540.1 - 2.8e-08 33.8 0.5 5.7e-08 32.8 0.5 1.5 1 0 0 1 1 1 1 Cnl2/NKP2 family protein FTA4 PF13093.6 ELR21540.1 - 0.014 15.3 3.4 0.017 15.0 3.4 1.2 1 0 0 1 1 1 0 Kinetochore complex Fta4 of Sim4 subunit, or CENP-50 Elongin_A PF06881.11 ELR21540.1 - 0.07 13.7 7.5 0.2 12.2 1.1 2.4 1 1 0 2 2 2 0 RNA polymerase II transcription factor SIII (Elongin) subunit A Occludin_ELL PF07303.13 ELR21540.1 - 0.079 13.7 6.5 2.1 9.1 0.2 2.3 1 1 1 2 2 2 0 Occludin homology domain V_ATPase_I PF01496.19 ELR21540.1 - 0.1 10.5 2.8 0.12 10.2 2.8 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF4559 PF15112.6 ELR21540.1 - 0.16 11.7 4.6 0.19 11.4 4.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4559) DUF4200 PF13863.6 ELR21540.1 - 0.29 11.5 10.2 2.7 8.4 1.4 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) EMP24_GP25L PF01105.24 ELR21540.1 - 0.38 10.7 2.3 0.69 9.8 2.3 1.5 1 1 0 1 1 1 0 emp24/gp25L/p24 family/GOLD IMD PF08397.11 ELR21540.1 - 0.9 8.9 7.0 0.45 9.9 0.6 2.1 1 1 1 2 2 2 0 IRSp53/MIM homology domain ADIP PF11559.8 ELR21540.1 - 1 9.4 7.6 7.3 6.7 7.1 2.0 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding rRNA_proc-arch PF13234.6 ELR21540.1 - 1.2 9.1 8.0 2.3 8.1 8.0 1.6 1 1 0 1 1 1 0 rRNA-processing arch domain ZapB PF06005.12 ELR21540.1 - 1.2 9.6 10.8 0.12 12.9 1.4 2.6 1 1 1 2 2 2 0 Cell division protein ZapB DUF4140 PF13600.6 ELR21540.1 - 2.3 8.7 5.7 2.4 8.6 1.9 2.3 1 1 1 2 2 2 0 N-terminal domain of unknown function (DUF4140) DHR10 PF18595.1 ELR21540.1 - 3 7.9 10.5 0.29 11.2 4.8 2.0 2 0 0 2 2 2 0 Designed helical repeat protein 10 domain ABC_tran_CTD PF16326.5 ELR21540.1 - 8.4 6.7 11.3 37 4.7 8.7 2.7 1 1 1 2 2 2 0 ABC transporter C-terminal domain SH3_2 PF07653.17 ELR21541.1 - 0.012 15.2 0.0 0.04 13.6 0.0 1.8 1 1 0 1 1 1 0 Variant SH3 domain SH3_9 PF14604.6 ELR21541.1 - 0.024 14.5 0.0 6.5 6.7 0.0 2.3 2 0 0 2 2 2 0 Variant SH3 domain PRK PF00485.18 ELR21542.1 - 1.8e-15 57.2 0.0 5.4e-13 49.1 0.0 2.2 1 1 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family AAA_24 PF13479.6 ELR21542.1 - 0.00025 20.8 0.0 0.0005 19.8 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 ELR21542.1 - 0.00043 20.5 0.0 0.0009 19.4 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 ELR21542.1 - 0.0012 19.4 0.0 0.0024 18.4 0.0 1.5 1 0 0 1 1 1 1 AAA domain CYTH PF01928.21 ELR21542.1 - 0.0048 16.9 0.0 0.011 15.6 0.0 1.6 1 0 0 1 1 1 1 CYTH domain AAA_16 PF13191.6 ELR21542.1 - 0.011 16.1 0.0 0.02 15.3 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain Mg_chelatase PF01078.21 ELR21542.1 - 0.015 14.7 0.0 0.026 13.9 0.0 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI NTPase_1 PF03266.15 ELR21542.1 - 0.016 15.2 0.1 0.062 13.2 0.0 2.0 3 0 0 3 3 2 0 NTPase NB-ARC PF00931.22 ELR21542.1 - 0.018 14.3 0.0 0.03 13.5 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain ATP_bind_1 PF03029.17 ELR21542.1 - 0.029 14.1 0.0 0.062 13.1 0.0 1.5 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein AAA_5 PF07728.14 ELR21542.1 - 0.042 13.9 0.0 0.083 12.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) Zeta_toxin PF06414.12 ELR21542.1 - 0.048 12.9 0.0 0.12 11.6 0.0 1.6 1 0 0 1 1 1 0 Zeta toxin AAA PF00004.29 ELR21542.1 - 0.05 14.0 0.1 0.14 12.6 0.0 1.8 2 0 0 2 2 1 0 ATPase family associated with various cellular activities (AAA) NACHT PF05729.12 ELR21542.1 - 0.055 13.4 0.0 0.1 12.5 0.0 1.4 1 0 0 1 1 1 0 NACHT domain AAA_22 PF13401.6 ELR21542.1 - 0.064 13.5 0.0 0.13 12.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_17 PF13207.6 ELR21542.1 - 0.13 12.7 0.2 0.35 11.3 0.0 1.8 2 0 0 2 2 1 0 AAA domain cobW PF02492.19 ELR21542.1 - 0.13 11.9 0.2 1.5 8.4 0.0 2.2 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain GTP_EFTU PF00009.27 ELR21543.1 - 2.2e-29 102.4 0.0 3.2e-29 101.9 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D2 PF03144.25 ELR21543.1 - 2.9e-08 34.0 0.1 6.2e-08 32.9 0.1 1.6 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 ELR21543.1 - 7.9e-08 32.4 0.0 1.4e-07 31.5 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase RIBIOP_C PF04950.12 ELR21543.1 - 0.00013 21.5 0.0 0.00092 18.7 0.0 2.0 1 1 0 1 1 1 1 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal SRPRB PF09439.10 ELR21543.1 - 0.0035 16.8 0.1 0.0098 15.3 0.1 1.7 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit cobW PF02492.19 ELR21543.1 - 0.008 15.8 0.5 0.034 13.8 0.1 1.9 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain AMMECR1 PF01871.17 ELR21545.1 - 2.2e-19 69.7 0.0 3e-19 69.2 0.0 1.2 1 0 0 1 1 1 1 AMMECR1 DnaJ PF00226.31 ELR21545.1 - 3.4e-15 55.9 0.3 1.4e-14 54.0 0.0 2.0 2 0 0 2 2 2 1 DnaJ domain DUF755 PF05501.11 ELR21545.1 - 1.1 9.6 11.1 2 8.7 11.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF755) DUF547 PF04784.14 ELR21546.1 - 3e-20 72.5 0.0 7.3e-20 71.2 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function, DUF547 RhoGEF PF00621.20 ELR21546.1 - 1.8e-19 70.7 0.3 1.4e-18 67.8 0.2 2.3 2 0 0 2 2 2 1 RhoGEF domain PH PF00169.29 ELR21546.1 - 2.3e-09 37.7 0.1 6.3e-09 36.3 0.0 1.8 2 0 0 2 2 2 1 PH domain PH_13 PF16652.5 ELR21546.1 - 7.6e-06 25.8 2.4 0.00023 21.0 1.9 3.1 3 1 0 3 3 3 1 Pleckstrin homology domain PH_16 PF17838.1 ELR21546.1 - 0.0011 18.8 0.3 0.0047 16.8 0.3 2.0 1 1 0 1 1 1 1 PH domain AAA_8 PF12780.7 ELR21546.1 - 0.013 14.9 0.9 0.24 10.7 0.1 2.4 2 0 0 2 2 2 0 P-loop containing dynein motor region D4 Spore_Cse60 PF10957.8 ELR21546.1 - 0.43 10.6 1.8 0.68 10.0 0.1 2.2 2 0 0 2 2 2 0 Sporulation protein Cse60 Lipase_GDSL_2 PF13472.6 ELR21547.1 - 2.5e-26 93.2 0.0 2.8e-26 93.0 0.0 1.0 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 ELR21547.1 - 2.6e-06 27.6 0.0 5.9e-06 26.4 0.0 1.6 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase YopX PF09643.10 ELR21547.1 - 0.018 15.1 0.0 0.027 14.5 0.0 1.2 1 0 0 1 1 1 0 YopX protein CBP_GIL PF10995.8 ELR21547.1 - 0.1 11.3 0.0 0.12 11.1 0.0 1.1 1 0 0 1 1 1 0 Cellulose biosynthesis GIL sCache_3_2 PF17203.4 ELR21547.1 - 0.1 12.7 0.0 0.18 11.9 0.0 1.4 1 1 0 1 1 1 0 Single cache domain 3 CH PF00307.31 ELR21548.1 - 2.5e-12 46.9 0.0 4.8e-12 46.0 0.0 1.5 1 0 0 1 1 1 1 Calponin homology (CH) domain CytochromB561_N PF09786.9 ELR21548.1 - 8.4e-05 21.8 13.3 0.00011 21.4 13.3 1.1 1 0 0 1 1 1 1 Cytochrome B561, N terminal CDC24 PF06395.11 ELR21548.1 - 0.0038 17.5 0.0 0.0093 16.2 0.0 1.6 2 0 0 2 2 1 1 CDC24 Calponin DUF936 PF06075.12 ELR21548.1 - 0.012 14.5 14.5 0.015 14.3 14.5 1.1 1 0 0 1 1 1 0 Plant protein of unknown function (DUF936) SPX PF03105.19 ELR21548.1 - 0.042 13.8 18.8 0.052 13.5 18.8 1.1 1 0 0 1 1 1 0 SPX domain Macoilin PF09726.9 ELR21548.1 - 0.074 11.6 9.7 0.093 11.3 9.7 1.2 1 0 0 1 1 1 0 Macoilin family Ndc1_Nup PF09531.10 ELR21548.1 - 0.14 10.8 11.0 0.17 10.5 11.0 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup SR-25 PF10500.9 ELR21548.1 - 0.94 9.0 42.0 0.83 9.2 27.8 2.3 1 1 1 2 2 2 0 Nuclear RNA-splicing-associated protein Apt1 PF10351.9 ELR21548.1 - 1.9 7.3 15.3 2.5 6.8 15.3 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain PAT1 PF09770.9 ELR21548.1 - 3.3 5.9 8.7 4 5.6 8.7 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF4551 PF15087.6 ELR21548.1 - 4.9 5.9 19.2 6.5 5.5 19.2 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) GREB1 PF15782.5 ELR21548.1 - 8.5 3.3 14.0 9.8 3.1 14.0 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Peptidase_S64 PF08192.11 ELR21548.1 - 9.5 4.6 14.4 12 4.3 14.4 1.1 1 0 0 1 1 1 0 Peptidase family S64 DUF508 PF04370.12 ELR21549.1 - 0.0071 16.1 0.2 0.013 15.3 0.2 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF508) SET PF00856.28 ELR21550.1 - 4.5e-15 56.4 0.4 7e-15 55.8 0.3 1.5 1 1 1 2 2 2 1 SET domain SDA1 PF05285.12 ELR21550.1 - 0.043 13.2 17.1 0.013 14.9 8.5 2.1 2 0 0 2 2 2 0 SDA1 Nop14 PF04147.12 ELR21550.1 - 0.66 8.1 19.2 0.87 7.7 13.3 2.0 2 0 0 2 2 2 0 Nop14-like family Apt1 PF10351.9 ELR21550.1 - 1.5 7.6 5.9 0.11 11.3 0.5 1.7 2 0 0 2 2 2 0 Golgi-body localisation protein domain Sporozoite_P67 PF05642.11 ELR21550.1 - 3.6 5.5 17.1 0.27 9.2 1.1 2.1 2 0 0 2 2 2 0 Sporozoite P67 surface antigen LAP1C PF05609.12 ELR21550.1 - 8.1 5.4 10.1 0.27 10.3 3.0 1.8 2 0 0 2 2 2 0 Lamina-associated polypeptide 1C (LAP1C) NOA36 PF06524.12 ELR21550.1 - 8.9 5.5 26.1 1.6 8.0 4.4 2.4 2 0 0 2 2 2 0 NOA36 protein SET PF00856.28 ELR21551.1 - 1.1e-13 51.9 0.3 2.2e-13 50.9 0.3 1.8 1 1 0 1 1 1 1 SET domain Apt1 PF10351.9 ELR21551.1 - 0.15 10.8 1.0 0.26 10.1 1.0 1.3 1 0 0 1 1 1 0 Golgi-body localisation protein domain DUF2677 PF10838.8 ELR21551.1 - 0.74 9.8 2.9 0.42 10.6 0.2 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2677) SDA1 PF05285.12 ELR21551.1 - 0.87 8.9 18.8 0.058 12.8 11.8 2.0 2 0 0 2 2 2 0 SDA1 NDUFB10 PF10249.9 ELR21552.1 - 0.0002 21.8 0.2 0.00023 21.6 0.2 1.0 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase subunit 10 Ank_4 PF13637.6 ELR21553.1 - 8.6e-17 61.3 0.8 1.9e-10 41.0 0.0 3.5 1 1 2 3 3 3 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 ELR21553.1 - 5.7e-14 52.5 0.8 2.3e-09 37.7 0.5 2.1 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 ELR21553.1 - 6.7e-13 48.6 0.7 1.7e-06 28.2 0.1 3.1 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.30 ELR21553.1 - 6.9e-11 42.1 1.1 1.1e-06 28.8 0.1 3.2 3 0 0 3 3 3 2 Ankyrin repeat Ank_3 PF13606.6 ELR21553.1 - 1.3e-10 40.5 0.1 0.00089 19.5 0.0 3.4 3 0 0 3 3 3 3 Ankyrin repeat Utp11 PF03998.13 ELR21554.1 - 1.7e-51 175.5 25.5 1.3e-39 136.6 14.8 2.0 1 1 1 2 2 2 2 Utp11 protein PurL_C PF16904.5 ELR21554.1 - 0.37 11.1 3.9 0.21 11.9 1.7 1.7 2 0 0 2 2 2 0 Phosphoribosylformylglycinamidine synthase II C-terminus NTP_transf_2 PF01909.23 ELR21557.1 - 8.8e-06 25.9 0.2 1.8e-05 24.9 0.0 1.7 2 0 0 2 2 2 1 Nucleotidyltransferase domain Polbeta PF18765.1 ELR21557.1 - 1.9e-05 24.6 0.1 4.7e-05 23.4 0.0 1.8 2 0 0 2 2 2 1 Polymerase beta, Nucleotidyltransferase RlaP PF10127.9 ELR21557.1 - 0.00097 18.8 0.0 0.0017 18.0 0.0 1.3 1 0 0 1 1 1 1 RNA repair pathway DNA polymerase beta family ERp29 PF07749.12 ELR21557.1 - 0.082 13.8 0.5 0.18 12.7 0.5 1.5 1 0 0 1 1 1 0 Endoplasmic reticulum protein ERp29, C-terminal domain UDG PF03167.19 ELR21558.1 - 4.6e-26 91.7 0.0 7.5e-26 91.0 0.0 1.3 1 0 0 1 1 1 1 Uracil DNA glycosylase superfamily CDC45 PF02724.14 ELR21558.1 - 0.5 8.6 4.1 0.76 8.0 4.1 1.3 1 0 0 1 1 1 0 CDC45-like protein TolA_bind_tri PF16331.5 ELR21560.1 - 0.11 12.6 2.4 0.18 11.9 2.4 1.3 1 0 0 1 1 1 0 TolA binding protein trimerisation WIYLD PF10440.9 ELR21560.1 - 0.16 11.8 0.9 0.38 10.6 0.0 2.1 2 0 0 2 2 2 0 Ubiquitin-binding WIYLD domain UPF0172 PF03665.13 ELR21561.1 - 0.17 11.9 0.0 0.24 11.4 0.0 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0172) UDG PF03167.19 ELR21563.1 - 0.0028 17.7 0.2 0.0051 16.8 0.2 1.4 1 0 0 1 1 1 1 Uracil DNA glycosylase superfamily CDC45 PF02724.14 ELR21563.1 - 0.19 10.0 3.6 0.19 10.0 3.6 1.0 1 0 0 1 1 1 0 CDC45-like protein DNA_pol_phi PF04931.13 ELR21563.1 - 0.95 7.5 7.3 0.9 7.6 7.3 1.2 1 0 0 1 1 1 0 DNA polymerase phi TolA_bind_tri PF16331.5 ELR21565.1 - 0.018 15.1 2.4 0.024 14.7 2.4 1.1 1 0 0 1 1 1 0 TolA binding protein trimerisation HtrL_YibB PF09612.10 ELR21566.1 - 2.8e-07 30.4 0.0 7.6e-07 28.9 0.0 1.7 2 0 0 2 2 2 1 Bacterial protein of unknown function (HtrL_YibB) Vps26 PF03643.15 ELR21566.1 - 0.038 13.0 0.0 0.063 12.3 0.0 1.2 1 0 0 1 1 1 0 Vacuolar protein sorting-associated protein 26 Iso_dh PF00180.20 ELR21569.1 - 2.5e-23 82.8 0.0 3.3e-23 82.4 0.0 1.1 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase HrpB_C PF08482.10 ELR21570.1 - 0.04 14.3 0.9 0.26 11.7 0.1 2.5 2 0 0 2 2 2 0 ATP-dependent helicase C-terminal MCR_C PF04609.12 ELR21570.1 - 6.5 5.7 9.7 0.64 9.0 3.2 2.3 2 0 0 2 2 2 0 Methyl-coenzyme M reductase operon protein C RabGAP-TBC PF00566.18 ELR21572.1 - 6.7e-35 120.7 3.4 2.4e-33 115.6 3.4 2.4 1 1 0 1 1 1 1 Rab-GTPase-TBC domain FYVE PF01363.21 ELR21572.1 - 1.8e-16 60.0 8.3 3.5e-16 59.1 8.3 1.5 1 0 0 1 1 1 1 FYVE zinc finger KSHV_K1 PF11049.8 ELR21572.1 - 0.006 16.5 0.3 0.013 15.4 0.3 1.5 1 0 0 1 1 1 1 Glycoprotein K1 of Kaposi's sarcoma-associated herpes virus IBR PF01485.21 ELR21572.1 - 0.14 12.4 8.5 0.31 11.3 8.5 1.5 1 0 0 1 1 1 0 IBR domain, a half RING-finger domain zf-RING_2 PF13639.6 ELR21572.1 - 0.26 11.7 7.3 0.61 10.5 7.3 1.6 1 0 0 1 1 1 0 Ring finger domain LRR_6 PF13516.6 ELR21573.1 - 5.3e-14 51.0 0.1 0.00061 19.6 0.3 4.3 4 0 0 4 4 4 3 Leucine Rich repeat LRR_4 PF12799.7 ELR21573.1 - 0.00036 20.8 0.0 0.13 12.7 0.0 2.5 2 0 0 2 2 2 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 ELR21573.1 - 0.0066 16.2 1.0 7.1 6.5 0.7 3.1 2 1 0 2 2 2 2 Leucine rich repeat LRR_2 PF07723.13 ELR21573.1 - 0.1 13.3 0.0 5.5 7.8 0.0 2.4 2 0 0 2 2 2 0 Leucine Rich Repeat FYVE PF01363.21 ELR21574.1 - 8.1e-17 61.1 5.0 1.3e-16 60.4 5.0 1.4 1 0 0 1 1 1 1 FYVE zinc finger HypA PF01155.19 ELR21574.1 - 0.11 12.6 1.9 0.23 11.5 1.9 1.6 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA CENP-B_dimeris PF09026.10 ELR21574.1 - 1.4 9.4 8.1 2.6 8.5 8.1 1.4 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Astro_capsid_p PF12226.8 ELR21574.1 - 1.8 7.6 6.7 2.8 7.0 6.7 1.2 1 0 0 1 1 1 0 Turkey astrovirus capsid protein Ras PF00071.22 ELR21575.1 - 1.7e-17 63.5 0.1 1.9e-16 60.1 0.1 2.0 1 1 0 1 1 1 1 Ras family Roc PF08477.13 ELR21575.1 - 2.4e-12 47.1 0.1 9.3e-11 42.0 0.1 2.1 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase AAA_24 PF13479.6 ELR21575.1 - 0.0046 16.7 0.0 0.0097 15.6 0.0 1.4 1 1 0 1 1 1 1 AAA domain MMR_HSR1 PF01926.23 ELR21575.1 - 0.068 13.3 0.0 0.1 12.7 0.0 1.5 1 1 0 1 1 1 0 50S ribosome-binding GTPase NACHT PF05729.12 ELR21575.1 - 0.072 13.0 0.0 0.21 11.5 0.0 1.6 2 0 0 2 2 2 0 NACHT domain AAA_22 PF13401.6 ELR21575.1 - 0.088 13.1 0.0 0.13 12.6 0.0 1.4 1 1 0 1 1 1 0 AAA domain Dioxygenase_N PF04444.14 ELR21575.1 - 0.089 12.6 0.0 0.15 11.9 0.0 1.5 1 0 0 1 1 1 0 Catechol dioxygenase N terminus AAA_5 PF07728.14 ELR21575.1 - 0.13 12.3 0.0 0.21 11.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) NTPase_1 PF03266.15 ELR21575.1 - 0.13 12.1 0.0 0.17 11.8 0.0 1.3 1 1 0 1 1 1 0 NTPase AAA_16 PF13191.6 ELR21575.1 - 0.14 12.6 0.0 0.14 12.5 0.0 1.2 1 0 0 1 1 1 0 AAA ATPase domain AAA_32 PF13654.6 ELR21575.1 - 0.14 10.9 0.0 0.18 10.5 0.0 1.1 1 0 0 1 1 1 0 AAA domain LRR_6 PF13516.6 ELR21576.1 - 6.3e-14 50.8 0.1 0.00065 19.6 0.3 4.3 4 0 0 4 4 4 3 Leucine Rich repeat LRR_4 PF12799.7 ELR21576.1 - 0.00039 20.7 0.0 0.14 12.6 0.0 2.6 2 0 0 2 2 2 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 ELR21576.1 - 0.0071 16.1 1.0 7.3 6.4 0.6 3.1 2 1 0 2 2 2 2 Leucine rich repeat LRR_2 PF07723.13 ELR21576.1 - 0.12 13.1 0.0 5.8 7.8 0.0 2.4 2 0 0 2 2 2 0 Leucine Rich Repeat GDP_Man_Dehyd PF16363.5 ELR21577.1 - 1.3e-65 222.0 0.1 1.4e-61 208.7 0.0 2.0 2 0 0 2 2 2 2 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 ELR21577.1 - 2.6e-49 167.9 0.2 3.4e-49 167.5 0.2 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 ELR21577.1 - 3e-17 62.7 0.0 8.3e-17 61.2 0.0 1.5 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein NAD_binding_4 PF07993.12 ELR21577.1 - 1.5e-16 60.4 0.2 3.8e-16 59.1 0.2 1.6 1 1 0 1 1 1 1 Male sterility protein 3Beta_HSD PF01073.19 ELR21577.1 - 3.3e-16 59.1 0.1 5.1e-16 58.5 0.1 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family RmlD_sub_bind PF04321.17 ELR21577.1 - 2.6e-14 53.0 0.0 3.7e-14 52.5 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain NAD_binding_10 PF13460.6 ELR21577.1 - 5.2e-08 33.0 0.0 1.2e-07 31.9 0.0 1.5 1 0 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 ELR21577.1 - 0.0027 17.3 0.1 0.0038 16.8 0.1 1.2 1 0 0 1 1 1 1 NmrA-like family MAT1 PF06391.13 ELR21577.1 - 0.0034 17.3 2.5 1.2 8.9 0.1 2.2 2 0 0 2 2 2 2 CDK-activating kinase assembly factor MAT1 Phi_1 PF04674.12 ELR21578.1 - 2e-06 27.3 8.3 3e-06 26.7 8.3 1.5 1 1 0 1 1 1 1 Phosphate-induced protein 1 conserved region PLA2G12 PF06951.11 ELR21579.1 - 1.7e-18 67.2 14.8 2e-18 67.0 14.8 1.0 1 0 0 1 1 1 1 Group XII secretory phospholipase A2 precursor (PLA2G12) ORC5_C PF14630.6 ELR21580.1 - 4.7e-44 151.0 0.0 6.8e-44 150.5 0.0 1.2 1 0 0 1 1 1 1 Origin recognition complex (ORC) subunit 5 C-terminus AAA_16 PF13191.6 ELR21580.1 - 2.1e-13 51.0 0.9 1.1e-12 48.7 0.9 2.0 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 ELR21580.1 - 4.7e-09 36.6 0.0 2e-08 34.6 0.0 1.9 2 0 0 2 2 2 1 AAA domain AAA PF00004.29 ELR21580.1 - 0.0019 18.6 0.0 0.0041 17.5 0.0 1.6 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) ATPase_2 PF01637.18 ELR21580.1 - 0.014 15.3 0.0 0.026 14.4 0.0 1.4 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea RuvB_N PF05496.12 ELR21580.1 - 0.1 12.4 0.0 0.17 11.6 0.0 1.3 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain CH PF00307.31 ELR21581.1 - 2.2e-46 156.5 0.3 4.6e-27 94.4 0.0 2.9 3 0 0 3 3 3 2 Calponin homology (CH) domain RhoGEF PF00621.20 ELR21581.1 - 1e-41 143.2 0.1 1e-41 143.2 0.1 2.7 3 0 0 3 3 3 1 RhoGEF domain CAMSAP_CH PF11971.8 ELR21581.1 - 9.4e-15 54.2 0.1 5.3e-08 32.6 0.0 2.7 2 0 0 2 2 2 2 CAMSAP CH domain CH_2 PF06294.11 ELR21581.1 - 2.8e-05 24.1 0.0 0.0037 17.4 0.0 2.5 2 0 0 2 2 2 1 CH-like domain in sperm protein IQ PF00612.27 ELR21581.1 - 0.002 17.7 0.9 0.002 17.7 0.9 2.7 2 0 0 2 2 2 1 IQ calmodulin-binding motif IQ_SEC7_PH PF16453.5 ELR21581.1 - 0.0057 16.6 0.0 0.019 15.0 0.0 1.9 1 0 0 1 1 1 1 PH domain Atg14 PF10186.9 ELR21581.1 - 2.6 7.1 10.5 5.4 6.0 10.5 1.5 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 NUDE_C PF04880.13 ELR21581.1 - 3.4 8.1 14.9 1.4 9.4 4.3 2.6 1 1 1 2 2 2 0 NUDE protein, C-terminal conserved region DUF4200 PF13863.6 ELR21581.1 - 4 7.9 27.7 0.17 12.3 14.7 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4200) PhoPQ_related PF10142.9 ELR21582.1 - 3.1e-171 569.0 3.0 4e-118 394.3 0.6 2.0 2 0 0 2 2 2 2 PhoPQ-activated pathogenicity-related protein Leg1 PF05612.12 ELR21582.1 - 0.076 12.2 0.0 14 4.7 0.0 2.5 2 0 0 2 2 2 0 Leg1 DUF2314 PF10077.9 ELR21582.1 - 0.17 11.9 0.1 12 5.9 0.0 3.3 4 0 0 4 4 4 0 Uncharacterized protein conserved in bacteria (DUF2314) Homeodomain PF00046.29 ELR21583.1 - 1.7e-16 59.8 1.6 6.7e-16 57.9 1.6 2.1 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 ELR21583.1 - 2.3e-07 30.6 0.1 7.5e-07 29.0 0.1 1.9 1 0 0 1 1 1 1 Homeobox KN domain Nucleo_P87 PF07267.11 ELR21583.1 - 0.84 8.4 4.7 2 7.2 4.7 1.7 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 RRM_1 PF00076.22 ELR21584.1 - 0.0018 18.1 0.0 0.0031 17.3 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) ABC2_membrane PF01061.24 ELR21585.1 - 1.8e-28 99.4 14.7 2.6e-28 98.9 14.7 1.2 1 0 0 1 1 1 1 ABC-2 type transporter ABC_tran PF00005.27 ELR21585.1 - 7.8e-10 39.4 0.3 2.8e-09 37.6 0.0 1.9 2 0 0 2 2 2 1 ABC transporter RRM_1 PF00076.22 ELR21585.1 - 4e-05 23.4 0.0 9.4e-05 22.2 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) AAA_21 PF13304.6 ELR21585.1 - 0.0017 18.2 0.0 0.0033 17.3 0.0 1.4 1 0 0 1 1 1 1 AAA domain, putative AbiEii toxin, Type IV TA system RWD PF05773.22 ELR21586.1 - 1.2e-18 67.4 1.8 1.2e-18 67.4 0.0 1.9 2 1 0 2 2 2 1 RWD domain DFRP_C PF16543.5 ELR21586.1 - 2.1e-08 34.6 0.7 2.1e-08 34.6 0.7 2.1 1 1 1 2 2 2 1 DRG Family Regulatory Proteins, Tma46 DUF1908 PF08926.11 ELR21586.1 - 0.0098 15.0 0.2 0.015 14.4 0.2 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF1908) AAA_12 PF13087.6 ELR21587.1 - 1.2e-64 217.6 0.0 2.1e-64 216.8 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 ELR21587.1 - 1.7e-63 214.9 0.7 1.7e-63 214.9 0.7 1.8 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.6 ELR21587.1 - 1.3e-09 38.5 0.0 8.8e-09 35.8 0.0 2.1 1 1 0 1 1 1 1 AAA domain AAA_30 PF13604.6 ELR21587.1 - 5.2e-09 36.1 0.0 0.00089 19.0 0.0 2.6 2 0 0 2 2 2 2 AAA domain Viral_helicase1 PF01443.18 ELR21587.1 - 1.4e-07 31.5 0.2 0.009 15.8 0.0 3.6 4 0 0 4 4 4 2 Viral (Superfamily 1) RNA helicase UvrD-helicase PF00580.21 ELR21587.1 - 1.9e-05 24.3 0.0 0.0004 20.0 0.0 2.3 1 1 0 1 1 1 1 UvrD/REP helicase N-terminal domain Golgin_A5 PF09787.9 ELR21587.1 - 0.00056 19.5 5.9 0.0012 18.4 5.9 1.5 1 0 0 1 1 1 1 Golgin subfamily A member 5 LMBR1 PF04791.16 ELR21587.1 - 0.0061 15.5 0.2 0.0086 15.0 0.2 1.2 1 0 0 1 1 1 1 LMBR1-like membrane protein AAA PF00004.29 ELR21587.1 - 0.034 14.6 0.0 0.14 12.6 0.0 2.2 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 ELR21587.1 - 0.042 14.1 0.0 0.4 10.9 0.0 2.6 2 0 0 2 2 2 0 AAA domain DEAD PF00270.29 ELR21587.1 - 0.045 13.5 0.1 10 5.9 0.0 2.4 2 0 0 2 2 2 0 DEAD/DEAH box helicase FapA PF03961.13 ELR21587.1 - 0.065 11.8 3.0 0.1 11.2 3.0 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A AAA_7 PF12775.7 ELR21587.1 - 0.093 12.2 0.0 0.18 11.3 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_24 PF13479.6 ELR21587.1 - 0.1 12.3 0.1 20 4.8 0.0 2.8 2 1 0 2 2 2 0 AAA domain AAA_16 PF13191.6 ELR21587.1 - 0.15 12.4 2.4 0.4 11.0 0.7 2.7 3 1 0 3 3 2 0 AAA ATPase domain DUF4407 PF14362.6 ELR21587.1 - 0.21 10.9 5.6 3.4 6.9 2.3 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) Filament PF00038.21 ELR21587.1 - 1.3 8.5 9.7 0.66 9.5 3.7 2.8 2 1 1 3 3 3 0 Intermediate filament protein Nup54 PF13874.6 ELR21587.1 - 2.6 8.1 9.8 6.6 6.8 0.2 3.0 2 1 0 2 2 2 0 Nucleoporin complex subunit 54 ABC_tran_CTD PF16326.5 ELR21587.1 - 3.4 8.0 8.3 2.3 8.5 0.4 3.2 3 0 0 3 3 3 0 ABC transporter C-terminal domain Spc7 PF08317.11 ELR21587.1 - 4.2 6.1 7.5 12 4.7 7.5 1.7 1 1 0 1 1 1 0 Spc7 kinetochore protein APG6_N PF17675.1 ELR21587.1 - 4.3 7.9 11.8 5.7 7.5 3.3 2.7 2 0 0 2 2 2 0 Apg6 coiled-coil region DUF4201 PF13870.6 ELR21587.1 - 6.6 6.4 10.5 92 2.7 10.5 2.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4201) TRAP_alpha PF03896.16 ELR21588.1 - 0.21 10.8 1.2 0.38 9.9 1.2 1.4 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit FAM176 PF14851.6 ELR21588.1 - 0.37 10.4 4.2 0.68 9.6 4.2 1.3 1 0 0 1 1 1 0 FAM176 family Ribosomal_60s PF00428.19 ELR21588.1 - 1.2 9.8 10.4 2.3 8.9 10.4 1.4 1 0 0 1 1 1 0 60s Acidic ribosomal protein Cytomega_UL84 PF06284.11 ELR21588.1 - 5.2 5.4 4.4 7.3 4.9 4.4 1.1 1 0 0 1 1 1 0 Cytomegalovirus UL84 protein HEAT PF02985.22 ELR21589.1 - 0.13 12.6 0.1 35 5.0 0.0 2.5 2 0 0 2 2 2 0 HEAT repeat SEN1_N PF12726.7 ELR21590.1 - 1.4e-26 93.0 6.1 2.4e-26 92.3 6.1 1.3 1 1 0 1 1 1 1 SEN1 N terminal Ank_2 PF12796.7 ELR21590.1 - 9.7e-21 74.2 0.1 3.6e-16 59.5 0.0 2.6 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.30 ELR21590.1 - 3.2e-19 68.4 0.0 2.1e-06 27.9 0.0 4.1 3 0 0 3 3 3 3 Ankyrin repeat Ank_4 PF13637.6 ELR21590.1 - 4.9e-19 68.4 0.0 1.5e-08 35.0 0.0 4.2 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 ELR21590.1 - 8.7e-17 59.5 0.0 6.1e-05 23.1 0.0 4.3 3 0 0 3 3 3 3 Ankyrin repeat Ank_5 PF13857.6 ELR21590.1 - 7.5e-14 51.6 0.6 7.6e-07 29.3 0.0 3.3 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 ELR21591.1 - 8.9e-22 77.5 0.1 1.7e-16 60.6 0.0 2.2 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.30 ELR21591.1 - 1.2e-21 76.1 0.1 2.6e-07 30.8 0.0 3.5 3 1 0 3 3 3 3 Ankyrin repeat Ank_4 PF13637.6 ELR21591.1 - 3.8e-21 75.2 0.0 1.3e-09 38.4 0.0 3.2 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 ELR21591.1 - 5.1e-19 66.4 0.0 7.3e-06 26.0 0.0 3.3 3 0 0 3 3 3 3 Ankyrin repeat Ank_5 PF13857.6 ELR21591.1 - 2.5e-18 65.9 0.6 6.5e-08 32.7 0.0 3.0 1 1 2 3 3 3 3 Ankyrin repeats (many copies) DUF4775 PF16001.5 ELR21592.1 - 0.02 14.3 38.1 0.03 13.7 38.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4775) N_NLPC_P60 PF12912.7 ELR21592.1 - 0.068 13.5 1.0 0.22 11.9 0.3 2.1 2 0 0 2 2 2 0 NLPC_P60 stabilising domain, N term DNA_gyraseA_C PF03989.13 ELR21592.1 - 0.13 11.7 0.1 0.27 10.7 0.1 1.5 1 0 0 1 1 1 0 DNA gyrase C-terminal domain, beta-propeller Hid1 PF12722.7 ELR21592.1 - 0.39 8.8 11.4 0.56 8.3 11.4 1.3 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein BAF1_ABF1 PF04684.13 ELR21592.1 - 0.48 9.4 20.8 0.68 8.9 20.8 1.1 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor Borrelia_P83 PF05262.11 ELR21592.1 - 0.94 7.9 18.7 1.4 7.3 18.7 1.2 1 0 0 1 1 1 0 Borrelia P83/100 protein Presenilin PF01080.17 ELR21592.1 - 1.4 7.6 19.2 2 7.1 19.2 1.3 1 0 0 1 1 1 0 Presenilin CDC27 PF09507.10 ELR21592.1 - 1.4 8.2 40.4 2.1 7.6 40.4 1.2 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 SLC12 PF03522.15 ELR21592.1 - 2.1 7.3 15.2 3.7 6.5 15.2 1.4 1 0 0 1 1 1 0 Solute carrier family 12 PPP4R2 PF09184.11 ELR21592.1 - 3.4 7.2 26.8 5.6 6.5 26.8 1.3 1 0 0 1 1 1 0 PPP4R2 CRT10 PF08728.10 ELR21592.1 - 3.5 5.7 11.7 4.8 5.2 11.7 1.1 1 0 0 1 1 1 0 CRT10 SAPS PF04499.15 ELR21592.1 - 3.6 6.3 11.8 5.9 5.6 11.8 1.3 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein CDC45 PF02724.14 ELR21592.1 - 5.5 5.2 21.9 8.7 4.5 21.9 1.2 1 0 0 1 1 1 0 CDC45-like protein Red1 PF07964.11 ELR21592.1 - 7.3 4.7 26.9 10 4.2 26.9 1.1 1 0 0 1 1 1 0 Rec10 / Red1 DUF4407 PF14362.6 ELR21592.1 - 8.2 5.7 9.7 14 4.9 9.7 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) PBP_N PF17093.5 ELR21593.1 - 3.8 7.8 9.2 2.4 8.4 7.9 1.4 1 1 0 1 1 1 0 Penicillin-binding protein N-terminus CBM9_2 PF16011.5 ELR21594.1 - 0.035 13.8 1.1 2.5 7.8 0.3 2.2 2 0 0 2 2 2 0 Carbohydrate-binding family 9 CBM9_1 PF06452.11 ELR21594.1 - 0.043 13.7 0.0 0.071 13.0 0.0 1.3 1 0 0 1 1 1 0 Carbohydrate family 9 binding domain-like RNA_pol_Rpc34 PF05158.12 ELR21595.1 - 9.4e-55 186.3 7.0 2e-41 142.5 0.8 3.0 1 1 2 3 3 3 3 RNA polymerase Rpc34 subunit TrmB PF01978.19 ELR21595.1 - 0.00011 22.0 0.1 0.0052 16.6 0.1 2.5 2 0 0 2 2 2 1 Sugar-specific transcriptional regulator TrmB PadR PF03551.14 ELR21595.1 - 0.0087 16.0 0.1 0.02 14.8 0.1 1.6 1 0 0 1 1 1 1 Transcriptional regulator PadR-like family DUF5557 PF17712.1 ELR21595.1 - 0.017 15.1 0.0 1.3 9.0 0.0 2.4 1 1 0 2 2 2 0 Family of unknown function (DUF5557) TBPIP PF07106.13 ELR21595.1 - 0.018 14.9 1.1 2.7 8.0 0.3 2.5 2 0 0 2 2 2 0 TBPIP/Hop2 winged helix domain RPA_C PF08784.11 ELR21595.1 - 0.041 14.5 0.1 1.1 10.0 0.0 2.2 2 0 0 2 2 2 0 Replication protein A C terminal Sigma_reg_C PF13791.6 ELR21595.1 - 0.051 13.8 0.5 0.13 12.5 0.1 1.7 2 0 0 2 2 2 0 Sigma factor regulator C-terminal HMD PF03201.16 ELR21595.1 - 0.055 13.7 0.1 2 8.7 0.0 2.3 2 0 0 2 2 2 0 H2-forming N5,N10-methylene-tetrahydromethanopterin dehydrogenase Cdc6_C PF09079.11 ELR21595.1 - 0.12 12.4 0.1 0.24 11.4 0.1 1.5 1 0 0 1 1 1 0 CDC6, C terminal winged helix domain DUF480 PF04337.12 ELR21595.1 - 0.12 12.4 0.2 5.3 7.1 0.1 2.8 3 0 0 3 3 3 0 Protein of unknown function, DUF480 B-block_TFIIIC PF04182.12 ELR21595.1 - 0.12 12.5 0.0 0.2 11.8 0.0 1.4 1 0 0 1 1 1 0 B-block binding subunit of TFIIIC YiaAB PF05360.14 ELR21596.1 - 0.0059 16.8 3.1 0.0059 16.8 3.1 2.3 2 0 0 2 2 2 1 yiaA/B two helix domain BAF250_C PF12031.8 ELR21597.1 - 0.015 14.6 0.0 0.016 14.6 0.0 1.1 1 0 0 1 1 1 0 SWI/SNF-like complex subunit BAF250/Osa CcmD PF04995.14 ELR21597.1 - 0.052 13.6 0.8 0.088 12.9 0.8 1.3 1 0 0 1 1 1 0 Heme exporter protein D (CcmD) MORN PF02493.20 ELR21598.1 - 2.6e-25 86.8 42.4 2.3e-06 27.2 0.6 7.8 7 1 0 7 7 7 6 MORN repeat F-box-like PF12937.7 ELR21598.1 - 0.0019 18.1 0.0 0.0031 17.4 0.0 1.3 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ELR21598.1 - 0.0032 17.3 0.2 0.0056 16.5 0.2 1.3 1 0 0 1 1 1 1 F-box domain DnaJ_C PF01556.18 ELR21600.1 - 2.2e-36 125.2 0.1 3e-36 124.7 0.1 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 ELR21600.1 - 1.2e-23 82.9 2.5 2.7e-23 81.9 2.5 1.6 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.19 ELR21600.1 - 5.9e-14 52.2 16.1 1e-13 51.4 16.1 1.4 1 0 0 1 1 1 1 DnaJ central domain Anti-TRAP PF15777.5 ELR21600.1 - 1.2e-07 31.5 10.5 0.0013 18.6 1.1 2.3 2 0 0 2 2 2 2 Tryptophan RNA-binding attenuator protein inhibitory protein HypA PF01155.19 ELR21600.1 - 2e-05 24.6 6.2 0.014 15.4 0.2 2.3 2 0 0 2 2 2 2 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-C3HC4_3 PF13920.6 ELR21600.1 - 0.018 14.9 6.0 1.4 8.9 0.7 2.2 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Lar_restr_allev PF14354.6 ELR21600.1 - 0.032 14.6 0.8 0.032 14.6 0.8 3.5 2 1 2 4 4 3 0 Restriction alleviation protein Lar DUF3797 PF12677.7 ELR21600.1 - 0.053 13.4 3.9 0.18 11.7 0.6 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF3797) DNA_ligase_ZBD PF03119.16 ELR21600.1 - 0.11 12.6 3.5 5.4 7.1 0.2 2.7 2 0 0 2 2 2 0 NAD-dependent DNA ligase C4 zinc finger domain TackOD1 PF18551.1 ELR21600.1 - 0.12 12.1 4.4 0.46 10.1 0.4 2.3 1 1 1 2 2 2 0 Thaumarchaeal output domain 1 zf-RING_5 PF14634.6 ELR21600.1 - 0.15 12.1 8.3 1.4 8.9 0.5 2.3 2 0 0 2 2 2 0 zinc-RING finger domain DZR PF12773.7 ELR21600.1 - 0.33 11.0 8.3 1.5 8.9 8.3 2.0 1 1 0 1 1 1 0 Double zinc ribbon zinc_ribbon_2 PF13240.6 ELR21600.1 - 0.51 10.1 13.3 0.085 12.6 0.7 3.9 4 0 0 4 4 4 0 zinc-ribbon domain Rad50_zn_hook PF04423.14 ELR21600.1 - 0.58 10.0 3.6 10 6.0 0.3 2.7 2 0 0 2 2 2 0 Rad50 zinc hook motif FdhE PF04216.12 ELR21600.1 - 1.1 9.1 2.6 1.8 8.4 2.6 1.3 1 0 0 1 1 1 0 Protein involved in formate dehydrogenase formation zf-CHY PF05495.12 ELR21600.1 - 1.3 9.5 4.9 14 6.2 0.3 2.3 2 0 0 2 2 2 0 CHY zinc finger NRDD PF13597.6 ELR21600.1 - 1.4 7.6 10.0 0.17 10.6 1.6 2.2 1 1 1 2 2 2 0 Anaerobic ribonucleoside-triphosphate reductase zf-ribbon_3 PF13248.6 ELR21600.1 - 1.5 8.4 10.0 7.7 6.1 0.3 3.4 3 0 0 3 3 3 0 zinc-ribbon domain zf-RING_10 PF16685.5 ELR21600.1 - 1.8 8.7 5.4 0.42 10.8 1.5 1.9 1 1 1 2 2 2 0 zinc RING finger of MSL2 BRO1 PF03097.18 ELR21601.1 - 3.3e-24 85.4 0.0 3.8e-24 85.2 0.0 1.1 1 0 0 1 1 1 1 BRO1-like domain ubiquitin PF00240.23 ELR21602.1 - 2.3e-32 110.6 8.8 1.1e-23 82.8 0.2 3.4 3 0 0 3 3 3 2 Ubiquitin family Rad60-SLD PF11976.8 ELR21602.1 - 6.5e-10 38.7 0.2 1e-07 31.7 0.1 3.0 2 0 0 2 2 2 1 Ubiquitin-2 like Rad60 SUMO-like zf-C3HC4_3 PF13920.6 ELR21602.1 - 9.5e-08 31.8 11.3 1.9e-07 30.8 11.3 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Ubiquitin_2 PF14560.6 ELR21602.1 - 0.00013 22.3 0.3 0.42 11.1 0.1 3.4 2 0 0 2 2 2 2 Ubiquitin-like domain Prok-RING_4 PF14447.6 ELR21602.1 - 0.00026 20.8 13.1 0.00056 19.7 13.1 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 Coilin_N PF15862.5 ELR21602.1 - 0.00065 19.5 3.4 0.00065 19.5 3.4 7.4 5 2 1 8 8 8 1 Coilin N-terminus zf-RING_2 PF13639.6 ELR21602.1 - 0.01 16.2 11.0 0.01 16.2 11.0 2.4 2 0 0 2 2 2 0 Ring finger domain zf-RING_5 PF14634.6 ELR21602.1 - 1.2 9.1 16.0 0.068 13.1 9.8 2.1 2 0 0 2 2 2 0 zinc-RING finger domain zf-RING_6 PF14835.6 ELR21602.1 - 2.7 7.9 6.5 4.9 7.1 6.5 1.4 1 0 0 1 1 1 0 zf-RING of BARD1-type protein RskA PF10099.9 ELR21602.1 - 7.8 6.8 0.0 7.8 6.8 0.0 5.1 4 2 1 5 5 5 0 Anti-sigma-K factor rskA DUF4042 PF13251.6 ELR21603.1 - 0.024 14.3 0.0 0.041 13.6 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4042) Longin PF13774.6 ELR21603.1 - 0.44 10.6 1.9 8.6 6.5 0.0 2.9 3 0 0 3 3 3 0 Regulated-SNARE-like domain DSPc PF00782.20 ELR21604.1 - 8.5e-16 58.0 0.0 1.2e-15 57.5 0.0 1.1 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.6 ELR21604.1 - 2.9e-07 30.7 0.0 4.6e-07 30.1 0.0 1.2 1 0 0 1 1 1 1 Inositol hexakisphosphate Y_phosphatase PF00102.27 ELR21604.1 - 0.00036 20.2 0.1 0.00064 19.4 0.0 1.4 1 1 0 1 1 1 1 Protein-tyrosine phosphatase Init_tRNA_PT PF04179.12 ELR21604.1 - 0.057 13.7 0.0 0.082 13.2 0.0 1.2 1 0 0 1 1 1 0 Rit1 DUSP-like domain CDKN3 PF05706.12 ELR21604.1 - 0.066 12.9 0.0 0.094 12.4 0.0 1.2 1 0 0 1 1 1 0 Cyclin-dependent kinase inhibitor 3 (CDKN3) Mito_carr PF00153.27 ELR21605.1 - 6.4e-52 173.5 9.9 6.8e-19 67.6 0.7 4.0 3 1 0 3 3 3 3 Mitochondrial carrier protein Ras PF00071.22 ELR21606.1 - 1.5e-62 210.0 0.0 6.5e-32 110.4 0.0 3.4 2 1 0 2 2 2 2 Ras family Roc PF08477.13 ELR21606.1 - 2.2e-21 76.3 2.6 1.2e-09 38.5 0.0 4.0 4 1 0 4 4 3 2 Ras of Complex, Roc, domain of DAPkinase PH PF00169.29 ELR21606.1 - 1.8e-19 70.1 0.6 2.2e-12 47.4 0.0 3.1 3 0 0 3 3 3 2 PH domain GTP_EFTU PF00009.27 ELR21606.1 - 3.4e-15 56.1 0.8 2.3e-08 33.8 0.0 2.8 2 1 0 2 2 2 2 Elongation factor Tu GTP binding domain Arf PF00025.21 ELR21606.1 - 8e-14 51.5 0.0 2.5e-06 27.1 0.0 2.3 2 0 0 2 2 2 2 ADP-ribosylation factor family MMR_HSR1 PF01926.23 ELR21606.1 - 9.8e-14 51.4 0.0 2.4e-05 24.4 0.0 3.3 3 0 0 3 3 3 2 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 ELR21606.1 - 1.2e-06 28.5 0.1 0.034 14.1 0.0 3.4 4 0 0 4 4 4 2 RsgA GTPase AAA_16 PF13191.6 ELR21606.1 - 3.4e-05 24.3 0.0 0.071 13.5 0.0 2.6 2 0 0 2 2 2 2 AAA ATPase domain Viral_helicase1 PF01443.18 ELR21606.1 - 0.0018 18.1 0.6 0.4 10.4 0.0 3.0 3 0 0 3 3 3 1 Viral (Superfamily 1) RNA helicase PH_11 PF15413.6 ELR21606.1 - 0.003 18.0 15.6 0.0039 17.6 0.2 4.4 4 1 0 4 4 3 2 Pleckstrin homology domain RNA_helicase PF00910.22 ELR21606.1 - 0.0055 17.1 1.1 4.9 7.6 0.0 4.5 4 1 0 4 4 4 1 RNA helicase ABC_tran PF00005.27 ELR21606.1 - 0.0069 16.9 1.6 2.5 8.6 0.0 3.5 3 0 0 3 3 2 1 ABC transporter AAA_28 PF13521.6 ELR21606.1 - 0.013 15.7 0.3 1.6 8.9 0.1 2.8 2 0 0 2 2 2 0 AAA domain NB-ARC PF00931.22 ELR21606.1 - 0.013 14.6 0.9 3.4 6.8 0.0 2.6 2 0 0 2 2 2 0 NB-ARC domain AAA_22 PF13401.6 ELR21606.1 - 0.046 14.0 0.0 1 9.6 0.0 2.5 2 0 0 2 2 2 0 AAA domain AAA_19 PF13245.6 ELR21606.1 - 0.063 13.6 0.0 3.7 7.9 0.0 2.6 2 0 0 2 2 2 0 AAA domain NACHT PF05729.12 ELR21606.1 - 0.12 12.3 0.1 5.3 6.9 0.0 2.4 2 0 0 2 2 2 0 NACHT domain DUF4604 PF15377.6 ELR21606.1 - 2.7 8.4 47.6 2.3 8.6 25.1 3.7 3 0 0 3 3 3 0 Domain of unknown function (DUF4604) Isochorismatase PF00857.20 ELR21607.1 - 2e-31 109.5 0.1 2.4e-31 109.3 0.1 1.1 1 0 0 1 1 1 1 Isochorismatase family Efg1 PF10153.9 ELR21608.1 - 4.1e-25 88.4 16.7 4.1e-25 88.4 16.7 3.5 3 2 1 4 4 4 1 rRNA-processing protein Efg1 Sec23_BS PF08033.12 ELR21609.1 - 0.018 15.8 0.0 0.035 14.8 0.0 1.5 1 0 0 1 1 1 0 Sec23/Sec24 beta-sandwich domain AAA_23 PF13476.6 ELR21610.1 - 0.14 12.6 0.0 0.29 11.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.6 ELR21610.1 - 0.15 11.8 0.0 0.38 10.5 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain BAG PF02179.16 ELR21611.1 - 3.7e-10 40.1 1.2 6.2e-10 39.4 1.2 1.5 1 1 0 1 1 1 1 BAG domain Peptidase_M3_N PF08439.10 ELR21611.1 - 0.28 11.5 0.3 0.28 11.5 0.3 1.9 2 1 0 2 2 2 0 Oligopeptidase F SLX9 PF15341.6 ELR21611.1 - 0.35 11.3 0.2 0.35 11.3 0.2 2.1 1 1 1 2 2 2 0 Ribosome biogenesis protein SLX9 Vta1 PF04652.16 ELR21612.1 - 9.6e-37 126.2 0.0 1.2e-36 125.8 0.0 1.1 1 0 0 1 1 1 1 Vta1 like Vta1_C PF18097.1 ELR21612.1 - 0.00041 20.0 0.2 0.011 15.4 0.1 2.4 2 0 0 2 2 2 1 Vta1 C-terminal domain Methyltransf_3 PF01596.17 ELR21613.1 - 1.9e-22 79.5 0.0 2e-22 79.4 0.0 1.0 1 0 0 1 1 1 1 O-methyltransferase Methyltransf_24 PF13578.6 ELR21613.1 - 0.00013 22.9 0.0 0.00019 22.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain DoxX_2 PF13564.6 ELR21614.1 - 0.012 15.7 3.5 0.012 15.7 3.5 1.9 1 1 1 2 2 2 0 DoxX-like family E3_UFM1_ligase PF09743.9 ELR21615.1 - 4.2e-66 223.4 3.5 5.8e-66 222.9 3.5 1.1 1 0 0 1 1 1 1 E3 UFM1-protein ligase 1 DUF4164 PF13747.6 ELR21615.1 - 0.073 13.3 1.5 0.12 12.7 0.3 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4164) WD40 PF00400.32 ELR21617.1 - 3.9e-47 157.2 13.9 1.8e-08 34.9 0.1 8.1 8 0 0 8 8 8 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ELR21617.1 - 9.9e-18 64.2 0.9 0.0044 17.3 0.0 6.0 1 1 6 7 7 7 5 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ELR21617.1 - 2e-08 33.4 0.6 0.38 9.3 0.0 4.2 3 1 1 4 4 4 4 Nucleoporin Nup120/160 eIF2A PF08662.11 ELR21617.1 - 7.9e-07 29.1 0.1 0.25 11.2 0.0 3.2 2 1 0 2 2 2 2 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 ELR21617.1 - 1.8e-06 27.1 0.7 0.24 10.3 0.0 3.7 3 1 0 4 4 4 3 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ELR21617.1 - 3.8e-06 26.4 0.0 0.096 12.0 0.0 3.2 2 1 2 4 4 4 3 WD40-like domain zf-MYND PF01753.18 ELR21618.1 - 1e-10 41.5 15.0 1.8e-10 40.7 15.0 1.4 1 0 0 1 1 1 1 MYND finger zf-Mss51 PF13824.6 ELR21618.1 - 1.2 9.2 6.8 1.4 9.1 5.6 1.7 2 0 0 2 2 2 0 Zinc-finger of mitochondrial splicing suppressor 51 zf-HIT PF04438.16 ELR21618.1 - 2.8 7.9 7.7 6 6.8 7.7 1.5 1 1 0 1 1 1 0 HIT zinc finger Ras PF00071.22 ELR21619.1 - 7.5e-50 168.7 1.5 9.1e-50 168.4 1.5 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR21619.1 - 2e-24 86.1 0.4 3.3e-24 85.4 0.4 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR21619.1 - 2.1e-14 53.3 0.3 2.7e-14 53.0 0.3 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 ELR21619.1 - 0.0026 17.3 0.2 0.0035 16.9 0.2 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain DUF4787 PF16029.5 ELR21620.1 - 1.1e-09 38.2 1.2 1.1e-09 38.2 1.2 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF4787) Mito_carr PF00153.27 ELR21621.1 - 2.7e-65 216.3 0.8 8.8e-22 76.9 0.0 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein EF-hand_7 PF13499.6 ELR21621.1 - 1e-22 80.4 3.1 2.2e-10 40.8 0.5 2.4 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 ELR21621.1 - 2.1e-22 76.9 9.7 2e-05 23.8 0.0 4.7 5 0 0 5 5 5 4 EF hand EF-hand_5 PF13202.6 ELR21621.1 - 1.9e-21 74.5 8.6 4.7e-05 22.7 0.1 4.5 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.6 ELR21621.1 - 3.2e-19 67.2 8.1 1.9e-05 24.2 0.1 4.6 4 0 0 4 4 4 4 EF-hand domain EF-hand_8 PF13833.6 ELR21621.1 - 1.4e-13 50.5 7.5 1e-05 25.3 0.1 4.3 3 2 2 5 5 5 4 EF-hand domain pair SPARC_Ca_bdg PF10591.9 ELR21621.1 - 1e-07 32.2 0.0 0.0028 17.9 0.0 2.3 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 ELR21621.1 - 0.0023 17.8 2.9 3 7.8 0.1 3.1 1 1 2 3 3 3 2 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.6 ELR21621.1 - 0.034 14.5 0.2 0.27 11.6 0.0 2.2 2 0 0 2 2 2 0 EF-hand domain Glyco_hydro_47 PF01532.20 ELR21623.1 - 1.7e-52 178.9 0.0 2.2e-52 178.5 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 PA PF02225.22 ELR21623.1 - 0.00041 20.3 0.0 0.00094 19.2 0.0 1.6 1 0 0 1 1 1 1 PA domain Pkinase PF00069.25 ELR21624.1 - 3.7e-18 65.8 1.0 6.9e-17 61.7 0.1 2.4 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR21624.1 - 5.9e-11 42.1 1.7 2.2e-09 37.0 0.3 2.4 2 1 0 2 2 2 1 Protein tyrosine kinase Mst1_SARAH PF11629.8 ELR21624.1 - 9.4e-10 38.4 4.4 2.1e-09 37.3 4.4 1.5 1 0 0 1 1 1 1 C terminal SARAH domain of Mst1 DUF1192 PF06698.11 ELR21624.1 - 0.029 14.4 0.0 0.082 13.0 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1192) RRN3 PF05327.11 ELR21624.1 - 0.27 9.7 5.4 0.29 9.6 5.4 1.2 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Spt5_N PF11942.8 ELR21624.1 - 0.32 12.0 8.2 0.75 10.8 8.2 1.6 1 0 0 1 1 1 0 Spt5 transcription elongation factor, acidic N-terminal DegQ PF08181.11 ELR21624.1 - 0.57 10.3 6.2 13 6.0 0.1 2.4 2 0 0 2 2 2 0 DegQ (SacQ) family DNA_ligase_ZBD PF03119.16 ELR21625.1 - 0.019 15.0 0.9 0.074 13.1 0.9 2.1 1 1 0 1 1 1 0 NAD-dependent DNA ligase C4 zinc finger domain Rad50_zn_hook PF04423.14 ELR21625.1 - 0.1 12.5 0.0 0.1 12.5 0.0 2.4 3 0 0 3 3 3 0 Rad50 zinc hook motif RlaP PF10127.9 ELR21626.1 - 2.7e-14 53.3 0.1 2e-11 44.0 0.0 2.7 2 1 0 2 2 2 2 RNA repair pathway DNA polymerase beta family Homeodomain PF00046.29 ELR21627.1 - 4.7e-16 58.4 0.2 9.9e-16 57.3 0.2 1.6 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 ELR21627.1 - 2e-06 27.6 0.1 5.3e-06 26.2 0.1 1.8 1 0 0 1 1 1 1 Homeobox KN domain Methyltransf_31 PF13847.6 ELR21628.1 - 2.7e-08 33.7 0.0 4.5e-08 33.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 ELR21628.1 - 1.3e-06 28.1 0.0 1.9e-06 27.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_25 PF13649.6 ELR21628.1 - 8.5e-06 26.4 0.0 2.5e-05 24.9 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain UPF0020 PF01170.18 ELR21628.1 - 9.3e-06 25.5 0.0 1.5e-05 24.8 0.0 1.4 1 0 0 1 1 1 1 Putative RNA methylase family UPF0020 Methyltransf_11 PF08241.12 ELR21628.1 - 0.011 16.3 0.0 0.022 15.4 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain PrmC_N PF17827.1 ELR21628.1 - 0.015 15.8 0.2 0.3 11.7 0.1 2.5 1 1 1 2 2 2 0 PrmC N-terminal domain Cons_hypoth95 PF03602.15 ELR21628.1 - 0.021 14.5 0.0 0.032 13.9 0.0 1.2 1 0 0 1 1 1 0 Conserved hypothetical protein 95 Pkinase PF00069.25 ELR21629.1 - 3.4e-67 226.6 0.0 5e-67 226.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR21629.1 - 1e-52 179.0 0.0 1.6e-52 178.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Mst1_SARAH PF11629.8 ELR21629.1 - 4.9e-09 36.1 4.4 4.9e-09 36.1 4.4 1.8 2 0 0 2 2 2 1 C terminal SARAH domain of Mst1 Pkinase_fungal PF17667.1 ELR21629.1 - 8.9e-07 28.0 0.2 2.3e-06 26.6 0.0 1.7 2 0 0 2 2 2 1 Fungal protein kinase Haspin_kinase PF12330.8 ELR21629.1 - 0.0045 16.0 0.9 0.25 10.2 0.0 2.8 2 1 0 2 2 2 1 Haspin like kinase domain DUF1192 PF06698.11 ELR21629.1 - 0.063 13.3 0.0 0.2 11.7 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1192) Abi_2 PF07751.11 ELR21629.1 - 0.064 13.5 1.4 0.19 12.0 0.0 2.1 2 0 0 2 2 2 0 Abi-like protein RRN3 PF05327.11 ELR21629.1 - 1.4 7.4 6.0 2 6.9 6.0 1.2 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Spt5_N PF11942.8 ELR21629.1 - 1.9 9.5 8.9 4.5 8.3 8.9 1.6 1 0 0 1 1 1 0 Spt5 transcription elongation factor, acidic N-terminal DAGK_acc PF00609.19 ELR21630.1 - 9.7e-39 133.3 0.0 1.6e-38 132.5 0.0 1.3 1 0 0 1 1 1 1 Diacylglycerol kinase accessory domain DAGK_cat PF00781.24 ELR21630.1 - 5.6e-23 80.9 0.2 1.4e-22 79.6 0.0 1.7 2 0 0 2 2 2 1 Diacylglycerol kinase catalytic domain C1_1 PF00130.22 ELR21630.1 - 1.1e-09 38.0 24.2 4.5e-05 23.2 12.0 2.5 2 0 0 2 2 2 2 Phorbol esters/diacylglycerol binding domain (C1 domain) C1_2 PF03107.16 ELR21630.1 - 2.3 8.6 16.5 0.13 12.5 6.6 2.5 2 0 0 2 2 2 0 C1 domain Zn_ribbon_17 PF17120.5 ELR21630.1 - 3.6 7.3 16.4 1.8 8.2 1.9 2.5 2 0 0 2 2 2 0 Zinc-ribbon, C4HC2 type RAP1 PF07218.11 ELR21630.1 - 5.2 5.2 17.3 10 4.2 17.3 1.4 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) NYN_YacP PF05991.11 ELR21631.1 - 0.015 15.2 0.1 0.024 14.5 0.1 1.4 1 0 0 1 1 1 0 YacP-like NYN domain RUN PF02759.19 ELR21632.1 - 4.9e-11 42.7 0.3 1.3e-10 41.4 0.0 1.9 2 0 0 2 2 2 1 RUN domain Borrelia_P83 PF05262.11 ELR21632.1 - 0.0062 15.1 33.2 0.01 14.4 33.2 1.3 1 0 0 1 1 1 1 Borrelia P83/100 protein FYVE PF01363.21 ELR21632.1 - 0.2 11.8 0.6 0.45 10.7 0.6 1.5 1 0 0 1 1 1 0 FYVE zinc finger MORN PF02493.20 ELR21633.1 - 1.7e-34 115.7 62.8 5.2e-07 29.2 0.7 9.5 10 0 0 10 10 10 9 MORN repeat Tudor_2 PF18104.1 ELR21633.1 - 0.029 14.1 13.8 3.3 7.5 0.0 6.0 7 0 0 7 7 7 0 Jumonji domain-containing protein 2A Tudor domain DUF5342 PF17277.2 ELR21633.1 - 2 8.8 7.6 2.5 8.5 0.4 3.6 2 1 1 4 4 4 0 Family of unknown function (DUF5342) adh_short PF00106.25 ELR21634.1 - 2.7e-31 108.6 0.0 4.4e-31 107.9 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ELR21634.1 - 3.4e-30 105.3 0.0 4.3e-30 105.0 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ELR21634.1 - 0.00067 19.6 0.0 0.0023 17.9 0.0 1.9 1 1 0 1 1 1 1 KR domain DUF3847 PF12958.7 ELR21634.1 - 0.018 15.1 0.2 0.044 13.9 0.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3847) ABC2_membrane PF01061.24 ELR21636.1 - 5.9e-36 123.9 17.6 8.7e-36 123.3 17.6 1.3 1 0 0 1 1 1 1 ABC-2 type transporter ABC_tran PF00005.27 ELR21636.1 - 1e-25 90.8 0.0 2.2e-25 89.7 0.0 1.6 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 ELR21636.1 - 0.00014 21.8 2.3 0.021 14.7 0.1 2.5 1 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system RsgA_GTPase PF03193.16 ELR21636.1 - 0.00034 20.6 0.1 0.00062 19.7 0.1 1.3 1 0 0 1 1 1 1 RsgA GTPase T2SSE PF00437.20 ELR21636.1 - 0.0042 16.2 0.4 0.01 14.9 0.1 1.7 2 0 0 2 2 2 1 Type II/IV secretion system protein AAA_25 PF13481.6 ELR21636.1 - 0.022 14.4 0.0 0.046 13.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain EF_assoc_1 PF08355.12 ELR21636.1 - 0.036 13.6 0.8 0.99 9.1 0.5 2.6 2 0 0 2 2 2 0 EF hand associated AAA_28 PF13521.6 ELR21636.1 - 0.037 14.3 0.8 0.079 13.2 0.8 1.5 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.6 ELR21636.1 - 0.078 12.7 0.2 0.16 11.7 0.2 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain NACHT PF05729.12 ELR21636.1 - 0.11 12.5 0.8 0.22 11.5 0.8 1.5 1 0 0 1 1 1 0 NACHT domain AAA_19 PF13245.6 ELR21636.1 - 0.14 12.5 0.5 0.45 10.9 0.5 1.8 1 0 0 1 1 1 0 AAA domain PAP_assoc PF03828.19 ELR21637.1 - 9.1e-20 70.6 0.1 2.6e-19 69.2 0.1 1.9 1 0 0 1 1 1 1 Cid1 family poly A polymerase NTP_transf_2 PF01909.23 ELR21637.1 - 7e-08 32.7 0.0 1.6e-07 31.5 0.0 1.6 1 0 0 1 1 1 1 Nucleotidyltransferase domain Polbeta PF18765.1 ELR21637.1 - 0.00097 19.2 0.0 0.0024 17.9 0.0 1.6 1 0 0 1 1 1 1 Polymerase beta, Nucleotidyltransferase Gtr1_RagA PF04670.12 ELR21638.1 - 5.2e-39 134.0 0.1 5.8e-39 133.8 0.1 1.0 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region PH PF00169.29 ELR21639.1 - 4.7e-44 149.2 2.4 1.2e-13 51.5 0.2 3.5 3 0 0 3 3 3 3 PH domain ArfGap PF01412.18 ELR21639.1 - 1e-37 128.8 0.1 4.2e-37 126.8 0.0 2.1 2 0 0 2 2 2 1 Putative GTPase activating protein for Arf PH_3 PF14593.6 ELR21639.1 - 6.2e-07 29.5 2.2 0.0089 16.1 0.2 3.1 2 2 0 2 2 2 2 PH domain PH_8 PF15409.6 ELR21639.1 - 8.9e-07 29.1 1.8 0.72 10.2 0.0 3.8 3 1 0 3 3 3 3 Pleckstrin homology domain Mcp5_PH PF12814.7 ELR21639.1 - 3e-05 24.1 0.4 0.035 14.2 0.1 2.5 2 0 0 2 2 2 2 Meiotic cell cortex C-terminal pleckstrin homology PH_9 PF15410.6 ELR21639.1 - 3.4e-05 24.2 1.9 5.3 7.4 0.0 4.5 3 1 0 3 3 3 2 Pleckstrin homology domain PH_13 PF16652.5 ELR21639.1 - 0.00054 19.8 1.1 5.2 6.9 0.0 4.1 4 0 0 4 4 4 1 Pleckstrin homology domain PH_2 PF08458.10 ELR21639.1 - 0.00062 20.1 0.0 0.22 11.9 0.0 3.3 3 0 0 3 3 3 1 Plant pleckstrin homology-like region PH_11 PF15413.6 ELR21639.1 - 0.042 14.3 26.4 0.053 13.9 1.7 5.8 5 3 0 5 5 5 0 Pleckstrin homology domain BURP PF03181.15 ELR21639.1 - 0.063 12.9 0.2 0.13 11.8 0.2 1.5 1 0 0 1 1 1 0 BURP domain Leu_zip PF15294.6 ELR21640.1 - 0.0021 17.6 5.4 0.0021 17.6 5.4 1.7 2 0 0 2 2 2 1 Leucine zipper OmpH PF03938.14 ELR21640.1 - 0.15 12.4 5.3 0.28 11.5 5.3 1.5 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) DUF4200 PF13863.6 ELR21640.1 - 0.15 12.5 12.1 0.26 11.7 12.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4200) FapA PF03961.13 ELR21640.1 - 0.46 9.0 2.2 0.64 8.6 2.2 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A DivIC PF04977.15 ELR21640.1 - 3.2 7.6 13.3 0.098 12.4 4.0 2.5 1 1 1 2 2 2 0 Septum formation initiator Spc24 PF08286.11 ELR21640.1 - 3.7 7.8 13.9 0.57 10.5 3.4 2.9 3 0 0 3 3 3 0 Spc24 subunit of Ndc80 Fmp27_WPPW PF10359.9 ELR21640.1 - 4.2 6.1 12.0 0.13 11.1 5.5 1.6 2 0 0 2 2 2 0 RNA pol II promoter Fmp27 protein domain YabA PF06156.13 ELR21640.1 - 4.6 8.0 6.9 1.9 9.2 2.1 2.3 2 0 0 2 2 2 0 Initiation control protein YabA SOG2 PF10428.9 ELR21640.1 - 5 6.2 35.5 8.8 5.4 35.5 1.4 1 0 0 1 1 1 0 RAM signalling pathway protein V_ATPase_I PF01496.19 ELR21640.1 - 5.8 4.7 5.8 10 3.9 5.8 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family APG6_N PF17675.1 ELR21640.1 - 6.6 7.3 24.0 13 6.3 19.9 2.4 1 1 2 3 3 3 0 Apg6 coiled-coil region DUF4472 PF14739.6 ELR21640.1 - 6.7 7.5 18.4 1.8 9.3 9.4 2.9 2 1 1 3 3 3 0 Domain of unknown function (DUF4472) Glyco_hydro_cc PF11790.8 ELR21641.1 - 3.3e-46 157.8 0.0 5.9e-46 157.0 0.0 1.3 1 1 0 1 1 1 1 Glycosyl hydrolase catalytic core SMC_N PF02463.19 ELR21642.1 - 2.9e-21 75.9 7.8 1.7e-17 63.6 0.4 2.7 1 1 2 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 ELR21642.1 - 2.1e-14 54.5 18.5 2.7e-13 50.9 18.5 2.0 1 1 0 1 1 1 1 AAA domain AAA_21 PF13304.6 ELR21642.1 - 2e-07 31.2 2.5 5.5e-07 29.7 0.1 2.1 1 1 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_15 PF13175.6 ELR21642.1 - 4.7e-06 26.6 12.4 2.1e-05 24.4 12.4 2.0 1 1 0 1 1 1 1 AAA ATPase domain AAA_29 PF13555.6 ELR21642.1 - 0.003 17.3 0.0 0.0055 16.4 0.0 1.3 1 0 0 1 1 1 1 P-loop containing region of AAA domain ABC_tran PF00005.27 ELR21642.1 - 0.0041 17.6 0.2 0.011 16.3 0.2 1.9 1 1 0 1 1 1 1 ABC transporter MSV199 PF10553.9 ELR21642.1 - 0.11 12.7 2.0 0.22 11.8 0.3 2.1 1 1 1 2 2 2 0 MSV199 domain AAA_13 PF13166.6 ELR21642.1 - 0.86 8.2 12.3 3.5 6.2 12.3 1.8 1 1 0 1 1 1 0 AAA domain VIT1 PF01988.19 ELR21642.1 - 5.5 6.8 5.8 9.3 6.1 0.0 2.3 2 0 0 2 2 2 0 VIT family V_ATPase_I PF01496.19 ELR21642.1 - 6.3 4.6 7.2 8.8 4.1 7.2 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family SMC_N PF02463.19 ELR21643.1 - 6.4e-44 150.0 10.4 5.1e-32 111.1 3.5 2.2 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 ELR21643.1 - 1.1e-14 55.0 5.0 8.9e-14 52.0 5.0 2.3 1 1 0 1 1 1 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_15 PF13175.6 ELR21643.1 - 4.7e-11 43.0 12.0 1.2e-10 41.7 12.0 1.8 1 1 0 1 1 1 1 AAA ATPase domain AAA_23 PF13476.6 ELR21643.1 - 6.8e-07 30.0 0.3 6.8e-07 30.0 0.3 4.6 3 1 1 4 4 4 1 AAA domain ABC_tran PF00005.27 ELR21643.1 - 0.00034 21.2 10.3 64 4.1 10.3 3.9 1 1 0 1 1 1 0 ABC transporter AAA_29 PF13555.6 ELR21643.1 - 0.054 13.3 0.0 0.1 12.3 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain Laminin_II PF06009.12 ELR21643.1 - 2.4 8.2 26.1 0.45 10.5 2.5 3.3 1 1 2 3 3 3 0 Laminin Domain II RRM_1 PF00076.22 ELR21644.1 - 2.4e-43 145.8 0.3 1.9e-15 56.4 0.0 3.3 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 ELR21644.1 - 3.6e-06 27.0 0.3 1.3 9.2 0.0 3.8 4 0 0 4 4 4 3 RNA recognition motif Nup35_RRM_2 PF14605.6 ELR21644.1 - 0.0014 18.6 0.2 0.079 13.0 0.1 2.4 2 0 0 2 2 2 1 Nup53/35/40-type RNA recognition motif DUF1206 PF06724.11 ELR21645.1 - 4.5 7.4 12.1 0.21 11.7 0.9 2.8 3 0 0 3 3 3 0 Domain of Unknown Function (DUF1206) IP_trans PF02121.18 ELR21646.1 - 1.9e-53 181.6 0.0 2.3e-53 181.3 0.0 1.0 1 0 0 1 1 1 1 Phosphatidylinositol transfer protein MUG113 PF13455.6 ELR21646.1 - 0.054 14.2 0.0 0.11 13.2 0.0 1.5 1 0 0 1 1 1 0 Meiotically up-regulated gene 113 CAP_N PF01213.19 ELR21646.1 - 3.4 7.1 5.6 5.4 6.4 5.6 1.3 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal CsbD PF05532.12 ELR21647.1 - 0.026 14.4 0.3 0.041 13.8 0.3 1.2 1 0 0 1 1 1 0 CsbD-like CH PF00307.31 ELR21649.1 - 2.7e-10 40.4 0.0 6e-10 39.3 0.0 1.5 1 0 0 1 1 1 1 Calponin homology (CH) domain CDC45 PF02724.14 ELR21649.1 - 7.8 4.7 31.6 2.5 6.3 6.6 2.1 2 0 0 2 2 2 0 CDC45-like protein IP_trans PF02121.18 ELR21651.1 - 2e-66 224.1 0.0 2.6e-66 223.7 0.0 1.0 1 0 0 1 1 1 1 Phosphatidylinositol transfer protein MUG113 PF13455.6 ELR21651.1 - 0.058 14.1 0.0 0.12 13.0 0.0 1.5 1 0 0 1 1 1 0 Meiotically up-regulated gene 113 CAP_N PF01213.19 ELR21651.1 - 1 8.8 5.5 1.6 8.1 5.5 1.3 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal CsbD PF05532.12 ELR21652.1 - 0.026 14.4 0.3 0.047 13.6 0.3 1.3 1 0 0 1 1 1 0 CsbD-like PAS PF00989.25 ELR21656.1 - 1.2e-05 25.3 0.0 2.4e-05 24.3 0.0 1.4 1 0 0 1 1 1 1 PAS fold PAS_3 PF08447.12 ELR21656.1 - 0.00022 21.4 0.0 0.00049 20.3 0.0 1.5 1 0 0 1 1 1 1 PAS fold PAS_9 PF13426.7 ELR21656.1 - 0.0014 18.9 0.0 0.0029 17.8 0.0 1.5 1 0 0 1 1 1 1 PAS domain CLTH PF10607.9 ELR21656.1 - 0.049 13.5 0.0 0.093 12.6 0.0 1.4 1 0 0 1 1 1 0 CTLH/CRA C-terminal to LisH motif domain PAS_4 PF08448.10 ELR21656.1 - 0.11 12.7 0.0 0.29 11.4 0.0 1.7 1 0 0 1 1 1 0 PAS fold DUF2207 PF09972.9 ELR21656.1 - 0.2 10.4 6.3 0.26 10.0 6.3 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF4191 PF13829.6 ELR21656.1 - 0.55 9.5 4.1 0.78 9.0 4.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4191) SR-25 PF10500.9 ELR21656.1 - 0.61 9.7 11.2 1.4 8.4 11.2 1.6 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein TraG_N PF07916.11 ELR21656.1 - 3.7 6.3 10.4 0.033 13.1 2.3 1.6 2 0 0 2 2 2 0 TraG-like protein, N-terminal region RRM_1 PF00076.22 ELR21657.1 - 3.9e-18 65.0 0.0 4.6e-18 64.8 0.0 1.1 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 ELR21657.1 - 0.063 12.9 0.0 0.087 12.4 0.0 1.2 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.22 ELR21658.1 - 1.9e-37 126.9 0.0 8.1e-18 64.0 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 ELR21658.1 - 5.4e-07 29.6 0.1 0.036 14.2 0.0 2.6 3 0 0 3 3 3 2 RNA recognition motif Nup35_RRM_2 PF14605.6 ELR21658.1 - 6.5e-07 29.3 0.1 0.027 14.5 0.0 2.6 2 0 0 2 2 2 2 Nup53/35/40-type RNA recognition motif RRM_occluded PF16842.5 ELR21658.1 - 5.6e-06 26.1 0.0 0.0082 16.0 0.0 2.4 2 0 0 2 2 2 2 Occluded RNA-recognition motif RRM_3 PF08777.11 ELR21658.1 - 0.0002 21.3 0.0 0.67 10.0 0.0 2.5 2 0 0 2 2 2 2 RNA binding motif RRM_5 PF13893.6 ELR21658.1 - 0.00024 20.7 0.0 0.0036 16.9 0.0 2.2 1 1 1 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_8 PF11835.8 ELR21658.1 - 0.02 15.1 0.0 0.24 11.6 0.0 2.1 2 0 0 2 2 2 0 RRM-like domain SPOR PF05036.13 ELR21658.1 - 0.05 14.0 0.0 19 5.7 0.0 2.6 2 0 0 2 2 2 0 Sporulation related domain DUF2740 PF10872.8 ELR21658.1 - 0.072 13.0 0.0 0.15 12.0 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2740) WD40 PF00400.32 ELR21659.1 - 1.5e-18 66.8 6.0 0.00011 22.8 0.0 5.4 5 2 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ELR21659.1 - 8.9e-05 22.7 0.1 2.4 8.5 0.0 4.2 1 1 2 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ELR21659.1 - 0.042 12.8 0.0 5.3 5.9 0.0 2.2 2 0 0 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein BBS2_Mid PF14783.6 ELR21659.1 - 0.097 12.7 0.0 10 6.2 0.0 2.5 2 0 0 2 2 2 0 Ciliary BBSome complex subunit 2, middle region SRP-alpha_N PF04086.13 ELR21659.1 - 2.3 8.1 17.1 3.8 7.4 17.1 1.3 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal Iwr1 PF08574.10 ELR21660.1 - 0.2 12.7 7.7 0.46 11.5 7.7 1.6 1 0 0 1 1 1 0 Transcription factor Iwr1 2OG-FeII_Oxy_2 PF13532.6 ELR21661.1 - 1.1e-28 100.7 0.0 1.4e-28 100.5 0.0 1.1 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily GCP_C_terminal PF04130.13 ELR21662.1 - 0.0011 18.5 0.0 0.002 17.7 0.0 1.3 1 1 0 1 1 1 1 Gamma tubulin complex component C-terminal IML1 PF12257.8 ELR21662.1 - 0.18 10.9 0.0 0.27 10.3 0.0 1.2 1 0 0 1 1 1 0 Vacuolar membrane-associated protein Iml1 RFX_DNA_binding PF02257.15 ELR21663.1 - 8.6e-18 64.8 0.1 1.9e-17 63.7 0.1 1.5 1 0 0 1 1 1 1 RFX DNA-binding domain TPR_12 PF13424.6 ELR21663.1 - 0.00019 21.7 0.4 0.029 14.7 0.1 2.5 1 1 1 2 2 2 2 Tetratricopeptide repeat Ammonium_transp PF00909.21 ELR21664.1 - 1.3e-109 366.6 27.1 1.9e-109 366.0 27.1 1.2 1 0 0 1 1 1 1 Ammonium Transporter Family NOA36 PF06524.12 ELR21665.1 - 0.031 13.6 0.3 0.045 13.1 0.3 1.2 1 0 0 1 1 1 0 NOA36 protein DFP PF04127.15 ELR21666.1 - 5.8e-15 55.6 0.0 5.4e-07 29.6 0.0 2.7 2 1 0 2 2 2 2 DNA / pantothenate metabolism flavoprotein ADH_zinc_N PF00107.26 ELR21667.1 - 7.9e-25 87.3 0.3 1.3e-24 86.6 0.3 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 ELR21667.1 - 4.7e-21 74.7 1.5 1.2e-20 73.4 1.5 1.7 1 1 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.6 ELR21667.1 - 2.9e-05 25.1 0.0 5e-05 24.4 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase 2-Hacid_dh_C PF02826.19 ELR21667.1 - 0.01 15.2 0.3 0.016 14.5 0.3 1.2 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain UDPG_MGDP_dh_N PF03721.14 ELR21667.1 - 0.03 13.9 0.2 0.047 13.3 0.2 1.3 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain TrkA_N PF02254.18 ELR21667.1 - 0.11 12.7 0.0 0.2 11.9 0.0 1.4 1 0 0 1 1 1 0 TrkA-N domain EF-hand_1 PF00036.32 ELR21669.1 - 4.4e-12 44.6 2.0 1.1e-05 24.6 0.1 2.5 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 ELR21669.1 - 1.2e-10 41.7 0.2 2.1e-10 40.9 0.2 1.4 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 ELR21669.1 - 1.9e-08 33.6 0.4 0.00029 20.5 0.2 2.5 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.6 ELR21669.1 - 0.00076 19.3 1.2 0.82 9.6 0.3 2.5 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 ELR21669.1 - 0.0022 17.4 0.1 0.41 10.2 0.0 2.5 2 0 0 2 2 2 2 EF hand DUF4139 PF13598.6 ELR21670.1 - 5.2e-09 36.1 0.5 1e-08 35.2 0.5 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4139) Top6b_C PF18000.1 ELR21670.1 - 0.00013 22.1 2.0 0.00065 19.9 0.4 2.4 2 0 0 2 2 2 1 Type 2 DNA topoisomerase 6 subunit B C-terminal domain Cbl_N2 PF02761.14 ELR21671.1 - 1.8e-06 28.5 0.3 5.1e-06 27.1 0.3 1.8 1 0 0 1 1 1 1 CBL proto-oncogene N-terminus, EF hand-like domain FHA PF00498.26 ELR21671.1 - 2.4e-06 27.8 0.1 7.3e-06 26.2 0.1 1.8 2 0 0 2 2 2 1 FHA domain CPSF100_C PF13299.6 ELR21671.1 - 0.003 17.8 0.5 0.0074 16.5 0.5 1.6 1 0 0 1 1 1 1 Cleavage and polyadenylation factor 2 C-terminal EF-hand_6 PF13405.6 ELR21671.1 - 0.15 12.1 0.2 3.6 7.8 0.1 2.6 2 0 0 2 2 2 0 EF-hand domain EF-hand_5 PF13202.6 ELR21671.1 - 0.15 11.6 0.1 0.37 10.4 0.1 1.7 1 0 0 1 1 1 0 EF hand EF-hand_1 PF00036.32 ELR21671.1 - 0.17 11.5 0.1 1.2 8.8 0.1 2.2 2 0 0 2 2 2 0 EF hand DUF5327 PF17261.2 ELR21671.1 - 0.82 10.4 4.9 2.9 8.7 2.5 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF5327) RAG1_imp_bd PF12560.8 ELR21671.1 - 0.9 9.0 6.0 0.41 10.1 0.1 2.1 2 0 0 2 2 2 0 RAG1 importin binding BSP_II PF05432.11 ELR21672.1 - 0.003 17.3 19.4 0.006 16.3 19.4 1.5 1 0 0 1 1 1 1 Bone sialoprotein II (BSP-II) Hamartin PF04388.12 ELR21672.1 - 0.0043 15.8 9.5 0.0052 15.5 9.5 1.1 1 0 0 1 1 1 1 Hamartin protein TFIIA PF03153.13 ELR21672.1 - 0.08 12.9 13.2 0.13 12.2 13.2 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit SDA1 PF05285.12 ELR21672.1 - 0.11 11.9 27.2 0.013 15.0 23.0 1.6 2 0 0 2 2 2 0 SDA1 Nop14 PF04147.12 ELR21672.1 - 0.48 8.6 28.2 0.82 7.8 28.2 1.3 1 0 0 1 1 1 0 Nop14-like family TFIIF_alpha PF05793.12 ELR21672.1 - 0.82 8.2 32.3 1.8 7.1 32.3 1.5 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Med19 PF10278.9 ELR21672.1 - 2.3 8.1 12.8 0.096 12.6 4.4 2.2 2 0 0 2 2 2 0 Mediator of RNA pol II transcription subunit 19 CDC27 PF09507.10 ELR21672.1 - 2.8 7.2 32.6 5 6.4 32.6 1.4 1 1 0 1 1 1 0 DNA polymerase subunit Cdc27 Raftlin PF15250.6 ELR21672.1 - 4.4 6.0 9.1 6.2 5.5 9.1 1.2 1 0 0 1 1 1 0 Raftlin PEPCK_ATP PF01293.20 ELR21673.1 - 1.2e-48 166.0 0.0 1.5e-48 165.6 0.0 1.1 1 0 0 1 1 1 1 Phosphoenolpyruvate carboxykinase NUDIX PF00293.28 ELR21673.1 - 9.7e-15 54.8 0.0 2.1e-14 53.7 0.0 1.6 1 0 0 1 1 1 1 NUDIX domain SH3_16 PF18348.1 ELR21673.1 - 0.033 14.0 0.2 0.067 13.0 0.2 1.5 1 0 0 1 1 1 0 Bacterial dipeptidyl-peptidase Sh3 domain PEPCK_ATP PF01293.20 ELR21674.1 - 1.7e-168 561.1 0.0 2e-168 560.9 0.0 1.0 1 0 0 1 1 1 1 Phosphoenolpyruvate carboxykinase DUF3990 PF13151.6 ELR21675.1 - 1.1e-08 34.9 0.0 1.8e-08 34.2 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3990) FoP_duplication PF13865.6 ELR21675.1 - 4.1 8.0 11.5 10 6.7 11.5 1.7 1 0 0 1 1 1 0 C-terminal duplication domain of Friend of PRMT1 RT_RNaseH PF17917.1 ELR21676.1 - 5e-07 30.0 0.2 1.8e-06 28.2 0.2 1.8 1 1 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 ELR21676.1 - 0.00085 19.3 0.1 0.0032 17.5 0.1 1.8 1 1 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Dynein_light PF01221.18 ELR21676.1 - 0.012 15.9 0.3 0.013 15.8 0.3 1.1 1 0 0 1 1 1 0 Dynein light chain type 1 PEPCK_ATP PF01293.20 ELR21680.1 - 8.7e-15 54.3 1.0 1.4e-07 30.6 0.1 2.0 1 1 1 2 2 2 2 Phosphoenolpyruvate carboxykinase Cir_N PF10197.9 ELR21680.1 - 0.12 12.5 0.0 0.18 12.0 0.0 1.2 1 0 0 1 1 1 0 N-terminal domain of CBF1 interacting co-repressor CIR PEPCK_ATP PF01293.20 ELR21681.1 - 5.4e-06 25.4 0.0 6.8e-06 25.0 0.0 1.1 1 0 0 1 1 1 1 Phosphoenolpyruvate carboxykinase DUF3119 PF11317.8 ELR21682.1 - 0.16 12.2 0.0 0.17 12.2 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3119) RVT_1 PF00078.27 ELR21684.1 - 0.062 12.8 0.0 0.085 12.4 0.0 1.2 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 ELR21686.1 - 0.00011 22.3 0.0 0.00028 21.0 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain NPR3 PF03666.13 ELR21687.1 - 7 5.3 6.0 8 5.1 6.0 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 NUDIX PF00293.28 ELR21688.1 - 2.2e-15 56.9 0.0 2.9e-15 56.5 0.0 1.2 1 0 0 1 1 1 1 NUDIX domain DUF3990 PF13151.6 ELR21690.1 - 1.4e-17 63.8 0.0 1.8e-17 63.4 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3990) VPS53_C PF16854.5 ELR21690.1 - 0.065 13.1 0.1 0.091 12.6 0.1 1.2 1 0 0 1 1 1 0 Vacuolar protein sorting-associated protein 53 C-terminus Cucumo_2B PF03263.13 ELR21691.1 - 8.5 6.9 9.6 1.4 9.4 0.5 2.1 2 0 0 2 2 2 0 Cucumovirus protein 2B CRIM PF16978.5 ELR21692.1 - 0.045 13.9 0.1 0.055 13.6 0.1 1.2 1 0 0 1 1 1 0 SAPK-interacting protein 1 (Sin1), middle CRIM domain ThiF PF00899.21 ELR21693.1 - 1.1e-16 60.9 0.1 1.5e-16 60.5 0.1 1.2 1 0 0 1 1 1 1 ThiF family Csm1_N PF18504.1 ELR21693.1 - 0.0049 17.2 1.6 0.0087 16.4 1.6 1.4 1 0 0 1 1 1 1 Csm1 N-terminal domain UDPG_MGDP_dh_N PF03721.14 ELR21693.1 - 0.0075 15.9 0.4 0.0075 15.9 0.4 1.5 2 0 0 2 2 2 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain FAD_binding_3 PF01494.19 ELR21693.1 - 0.014 14.6 0.1 0.022 14.0 0.1 1.3 1 0 0 1 1 1 0 FAD binding domain YscO PF07321.12 ELR21693.1 - 0.023 14.7 2.2 0.029 14.3 2.2 1.2 1 0 0 1 1 1 0 Type III secretion protein YscO TrkA_N PF02254.18 ELR21693.1 - 0.039 14.2 1.2 0.098 12.9 0.2 2.0 2 0 0 2 2 2 0 TrkA-N domain SH3BP5 PF05276.14 ELR21693.1 - 0.044 13.6 0.7 0.068 13.0 0.7 1.2 1 0 0 1 1 1 0 SH3 domain-binding protein 5 (SH3BP5) SlyX PF04102.12 ELR21693.1 - 0.059 14.0 4.4 0.12 13.0 4.4 1.6 1 1 0 1 1 1 0 SlyX DUF3138 PF11336.8 ELR21693.1 - 0.065 11.8 1.2 0.073 11.7 1.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) PglD_N PF17836.1 ELR21693.1 - 0.071 13.8 0.2 0.18 12.5 0.2 1.7 1 0 0 1 1 1 0 PglD N-terminal domain DUF2680 PF10925.8 ELR21693.1 - 0.072 13.1 4.1 0.1 12.6 3.1 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF2680) ABC_tran_CTD PF16326.5 ELR21693.1 - 0.093 13.0 5.5 0.23 11.7 5.5 1.7 1 1 1 2 2 2 0 ABC transporter C-terminal domain 2-Hacid_dh_C PF02826.19 ELR21693.1 - 0.1 12.0 1.8 0.067 12.5 0.4 1.6 2 1 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain THOC7 PF05615.13 ELR21693.1 - 0.11 12.8 2.1 0.15 12.4 2.1 1.2 1 0 0 1 1 1 0 Tho complex subunit 7 Sacchrp_dh_NADP PF03435.18 ELR21693.1 - 0.14 12.4 1.0 0.37 11.0 0.1 2.0 2 0 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain DivIC PF04977.15 ELR21693.1 - 0.24 11.2 6.5 0.24 11.2 4.6 1.9 2 0 0 2 2 2 0 Septum formation initiator LPP PF04728.13 ELR21693.1 - 0.46 10.9 4.9 0.41 11.1 3.1 1.7 2 0 0 2 2 2 0 Lipoprotein leucine-zipper ABC_tran_Xtn PF12848.7 ELR21693.1 - 0.58 10.2 5.5 1.2 9.3 5.2 1.7 1 1 1 2 2 2 0 ABC transporter RFX_DNA_binding PF02257.15 ELR21695.1 - 3.2e-09 37.3 0.0 4e-09 37.0 0.0 1.1 1 0 0 1 1 1 1 RFX DNA-binding domain Pox_D5 PF03288.16 ELR21695.1 - 0.043 14.3 0.1 0.05 14.1 0.1 1.2 1 0 0 1 1 1 0 Poxvirus D5 protein-like TPR_12 PF13424.6 ELR21696.1 - 2e-117 383.6 35.2 2.3e-22 79.1 0.5 5.2 1 1 6 7 7 7 7 Tetratricopeptide repeat TPR_10 PF13374.6 ELR21696.1 - 1.3e-82 269.7 5.6 3.6e-11 42.6 0.0 7.0 7 0 0 7 7 7 7 Tetratricopeptide repeat TPR_1 PF00515.28 ELR21696.1 - 1.9e-38 128.7 16.2 5.8e-07 29.1 0.1 7.1 7 0 0 7 7 7 7 Tetratricopeptide repeat TPR_7 PF13176.6 ELR21696.1 - 5.6e-38 126.2 9.3 6e-07 29.0 0.0 7.1 7 0 0 7 7 7 6 Tetratricopeptide repeat TPR_2 PF07719.17 ELR21696.1 - 6.4e-30 100.8 19.3 6.1e-05 22.8 0.1 7.1 7 0 0 7 7 7 7 Tetratricopeptide repeat TPR_8 PF13181.6 ELR21696.1 - 1.2e-26 90.6 18.6 6.1e-06 26.1 0.1 7.2 7 0 0 7 7 7 5 Tetratricopeptide repeat TPR_16 PF13432.6 ELR21696.1 - 2e-17 63.6 13.0 0.059 14.0 0.0 7.1 6 1 0 6 6 6 5 Tetratricopeptide repeat TPR_14 PF13428.6 ELR21696.1 - 1.5e-15 56.6 8.8 0.24 12.3 0.0 7.1 4 2 3 7 7 7 4 Tetratricopeptide repeat TPR_19 PF14559.6 ELR21696.1 - 7.7e-15 55.2 7.6 1.1e-05 25.9 0.1 4.9 4 1 1 5 5 5 3 Tetratricopeptide repeat TPR_17 PF13431.6 ELR21696.1 - 5.5e-12 45.2 7.2 0.0062 16.8 0.1 7.0 6 2 0 6 6 6 2 Tetratricopeptide repeat TPR_MalT PF17874.1 ELR21696.1 - 4.5e-10 39.4 0.3 0.0026 17.2 0.1 3.0 1 1 2 3 3 3 3 MalT-like TPR region SNAP PF14938.6 ELR21696.1 - 3.9e-09 36.3 0.5 0.017 14.6 0.0 3.0 2 1 0 2 2 2 2 Soluble NSF attachment protein, SNAP SHNi-TPR PF10516.9 ELR21696.1 - 1.8e-08 33.7 0.2 0.44 10.0 0.1 5.5 6 0 0 6 6 5 2 SHNi-TPR TPR_11 PF13414.6 ELR21696.1 - 1.1e-06 28.2 16.2 0.45 10.2 0.0 7.0 5 1 1 6 6 6 3 TPR repeat DUF2225 PF09986.9 ELR21696.1 - 2e-06 27.7 0.4 0.00038 20.3 0.0 2.7 1 1 2 3 3 3 1 Uncharacterized protein conserved in bacteria (DUF2225) TPR_5 PF12688.7 ELR21696.1 - 2.4e-06 27.8 2.5 2.2 8.6 0.0 5.4 4 1 2 6 6 5 1 Tetratrico peptide repeat TPR_6 PF13174.6 ELR21696.1 - 5.9e-06 26.6 16.1 1.7 9.4 0.0 6.0 7 0 0 7 7 5 3 Tetratricopeptide repeat TPR_4 PF07721.14 ELR21696.1 - 1.3e-05 25.3 1.3 5.5 7.9 0.0 5.8 7 0 0 7 7 5 0 Tetratricopeptide repeat MIT PF04212.18 ELR21696.1 - 1.6e-05 24.9 10.7 4.5 7.4 0.0 6.0 5 1 1 7 7 6 1 MIT (microtubule interacting and transport) domain TPR_9 PF13371.6 ELR21696.1 - 6.1e-05 23.1 4.4 0.0041 17.2 0.1 3.9 3 2 1 4 4 4 1 Tetratricopeptide repeat ANAPC3 PF12895.7 ELR21696.1 - 0.00012 22.2 8.3 0.036 14.3 0.2 5.2 1 1 4 5 5 5 1 Anaphase-promoting complex, cyclosome, subunit 3 RPN7 PF10602.9 ELR21696.1 - 0.0017 18.1 4.1 0.96 9.1 0.0 4.4 1 1 2 4 4 4 1 26S proteasome subunit RPN7 TPR_3 PF07720.12 ELR21696.1 - 0.0031 17.5 17.1 0.89 9.6 0.1 6.1 6 1 0 6 6 6 1 Tetratricopeptide repeat PPR PF01535.20 ELR21696.1 - 0.0067 16.6 0.9 11 6.6 0.0 4.7 5 0 0 5 5 4 0 PPR repeat HopA1 PF17914.1 ELR21696.1 - 0.0096 15.7 0.1 4.5 7.0 0.0 2.4 2 0 0 2 2 2 1 HopA1 effector protein family SPO22 PF08631.10 ELR21696.1 - 0.011 15.2 0.5 0.47 9.9 0.1 3.1 1 1 0 2 2 2 0 Meiosis protein SPO22/ZIP4 like CotJB PF12652.7 ELR21696.1 - 0.011 15.9 1.4 16 5.8 0.0 4.1 3 1 2 5 5 4 0 CotJB protein DUF1925 PF09094.11 ELR21696.1 - 0.025 14.9 0.1 58 4.1 0.0 4.1 3 2 1 5 5 4 0 Domain of unknown function (DUF1925) Tcf25 PF04910.14 ELR21696.1 - 0.026 13.6 0.0 2.7 7.0 0.0 2.9 2 1 1 3 3 3 0 Transcriptional repressor TCF25 SRP68 PF16969.5 ELR21696.1 - 0.073 12.1 0.1 15 4.4 0.1 3.0 1 1 1 2 2 2 0 RNA-binding signal recognition particle 68 Coatomer_E PF04733.14 ELR21696.1 - 0.088 12.2 1.7 3.1 7.1 0.0 3.1 3 1 1 4 4 4 0 Coatomer epsilon subunit DUF2989 PF11207.8 ELR21696.1 - 0.1 12.3 0.7 30 4.3 0.0 3.3 2 2 1 4 4 4 0 Protein of unknown function (DUF2989) DUF4404 PF14357.6 ELR21696.1 - 0.11 13.2 0.6 1.2e+02 3.5 0.0 4.2 3 1 2 5 5 4 0 Domain of unknown function (DUF4404) Mad3_BUB1_I PF08311.12 ELR21696.1 - 0.12 12.3 4.8 31 4.6 0.3 3.9 4 1 0 4 4 4 0 Mad3/BUB1 homology region 1 RPN6_N PF18055.1 ELR21696.1 - 0.17 12.2 0.2 14 6.1 0.0 3.3 4 0 0 4 4 4 0 26S proteasome regulatory subunit RPN6 N-terminal domain DUF4810 PF16068.5 ELR21696.1 - 0.37 11.4 3.8 16 6.1 0.0 4.0 4 1 1 5 5 5 0 Domain of unknown function (DUF4810) DUF5113 PF17140.4 ELR21696.1 - 0.59 9.9 5.5 17 5.2 0.0 4.2 3 3 3 6 6 6 0 Domain of unknown function (DUF5113) Dus PF01207.17 ELR21697.1 - 4.3e-35 121.3 0.0 2.6e-17 62.9 0.0 2.1 2 0 0 2 2 2 2 Dihydrouridine synthase (Dus) NanE PF04131.14 ELR21697.1 - 0.089 12.0 0.0 0.14 11.3 0.0 1.2 1 0 0 1 1 1 0 Putative N-acetylmannosamine-6-phosphate epimerase DHO_dh PF01180.21 ELR21697.1 - 0.11 11.7 0.0 0.16 11.1 0.0 1.2 1 0 0 1 1 1 0 Dihydroorotate dehydrogenase ArfGap PF01412.18 ELR21698.1 - 5e-32 110.4 0.1 1.2e-31 109.2 0.1 1.7 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf ubiquitin PF00240.23 ELR21699.1 - 0.00043 20.0 0.1 0.00055 19.6 0.1 1.2 1 0 0 1 1 1 1 Ubiquitin family HisK_sensor PF18698.1 ELR21700.1 - 0.016 15.6 0.3 0.03 14.7 0.3 1.4 1 0 0 1 1 1 0 Histidine kinase sensor domain MIT PF04212.18 ELR21701.1 - 0.0089 16.1 6.0 0.01 15.9 4.1 2.1 2 0 0 2 2 2 1 MIT (microtubule interacting and transport) domain DUF3369 PF11849.8 ELR21701.1 - 0.054 13.7 0.3 0.11 12.8 0.1 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF3369) Sel1 PF08238.12 ELR21704.1 - 5.4e-20 71.4 5.7 9e-07 29.4 0.2 4.6 4 0 0 4 4 4 4 Sel1 repeat TPR_6 PF13174.6 ELR21704.1 - 6 7.7 11.3 6.7 7.6 0.1 4.6 5 0 0 5 5 5 0 Tetratricopeptide repeat PLAC8 PF04749.17 ELR21705.1 - 1.6e-10 41.9 12.9 1.8e-10 41.7 12.9 1.0 1 0 0 1 1 1 1 PLAC8 family CE2_N PF17996.1 ELR21706.1 - 4.9e-14 52.2 0.4 8.6e-14 51.5 0.4 1.4 1 0 0 1 1 1 1 Carbohydrate esterase 2 N-terminal Lipase_GDSL_2 PF13472.6 ELR21706.1 - 2.8e-11 44.2 0.0 4.9e-11 43.3 0.0 1.4 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 ELR21706.1 - 1.1e-05 25.5 0.0 6.9e-05 22.9 0.0 2.1 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase HYR PF02494.16 ELR21706.1 - 0.023 15.0 0.0 0.064 13.6 0.0 1.7 1 0 0 1 1 1 0 HYR domain Glyco_hydro_25 PF01183.20 ELR21707.1 - 6.7e-10 39.4 2.2 7.9e-10 39.2 2.2 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 25 DUF1610 PF07754.11 ELR21707.1 - 0.33 11.0 1.4 0.65 10.0 1.4 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1610) DUF3784 PF12650.7 ELR21708.1 - 0.2 11.8 6.3 0.27 11.4 6.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3784) Glyco_hydro_25 PF01183.20 ELR21709.1 - 3.3e-32 112.1 0.0 1.4e-09 38.3 0.0 3.0 3 0 0 3 3 3 3 Glycosyl hydrolases family 25 Thiamine_BP PF01910.17 ELR21709.1 - 4e-08 33.0 0.0 0.21 11.5 0.0 3.3 3 0 0 3 3 3 3 Thiamine-binding protein Lar_restr_allev PF14354.6 ELR21709.1 - 3.7e-06 27.2 0.2 0.72 10.3 0.0 3.8 3 0 0 3 3 3 1 Restriction alleviation protein Lar zf-C2H2_4 PF13894.6 ELR21709.1 - 4.2e-05 24.0 3.9 0.37 11.7 0.1 3.6 3 0 0 3 3 3 1 C2H2-type zinc finger zf-Di19 PF05605.12 ELR21709.1 - 4.5e-05 23.7 2.0 0.52 10.7 0.1 3.3 3 0 0 3 3 3 1 Drought induced 19 protein (Di19), zinc-binding Zn_Tnp_IS1595 PF12760.7 ELR21709.1 - 5.2e-05 23.1 0.3 2.6 8.1 0.0 3.5 3 0 0 3 3 3 1 Transposase zinc-ribbon domain Cys_rich_CPXG PF14255.6 ELR21709.1 - 0.00038 20.3 2.3 0.6 10.1 0.1 3.5 3 0 0 3 3 3 1 Cysteine-rich CPXCG Terminase_GpA PF05876.12 ELR21709.1 - 0.00052 18.7 0.0 1.4 7.3 0.0 3.0 3 0 0 3 3 3 1 Phage terminase large subunit (GpA) zf_UBZ PF18439.1 ELR21709.1 - 0.0013 18.3 3.8 2 8.1 0.1 3.4 3 0 0 3 3 3 1 Ubiquitin-Binding Zinc Finger zf-C2H2 PF00096.26 ELR21709.1 - 0.0015 18.9 6.8 4 8.1 0.3 3.6 3 0 0 3 3 3 1 Zinc finger, C2H2 type CpXC PF14353.6 ELR21709.1 - 0.0025 17.8 0.1 15 5.6 0.0 3.2 3 0 0 3 3 3 0 CpXC protein VirArc_Nuclease PF12187.8 ELR21709.1 - 0.041 13.4 0.1 15 5.0 0.0 3.0 3 0 0 3 3 3 0 Viral/Archaeal nuclease zf-LITAF-like PF10601.9 ELR21709.1 - 0.049 13.9 0.5 19 5.6 0.0 3.3 3 0 0 3 3 3 0 LITAF-like zinc ribbon domain Pox_E10 PF04805.12 ELR21709.1 - 0.072 13.0 0.0 44 4.0 0.0 3.3 3 0 0 3 3 3 0 E10-like protein conserved region DUF1610 PF07754.11 ELR21709.1 - 0.074 13.0 19.2 2.8 8.0 1.2 4.1 3 0 0 3 3 3 0 Domain of unknown function (DUF1610) CHCH PF06747.13 ELR21709.1 - 0.093 12.9 0.2 38 4.6 0.0 3.4 3 0 0 3 3 3 0 CHCH domain Zn-ribbon_8 PF09723.10 ELR21709.1 - 0.12 12.5 4.0 34 4.7 0.1 3.4 3 0 0 3 3 3 0 Zinc ribbon domain GHL6 PF14871.6 ELR21709.1 - 0.15 12.2 0.0 45 4.2 0.0 3.1 3 0 0 3 3 3 0 Hypothetical glycosyl hydrolase 6 Linker_histone PF00538.19 ELR21709.1 - 0.19 12.1 0.0 58 4.2 0.0 3.5 4 0 0 4 4 3 0 linker histone H1 and H5 family zf-C2HC_2 PF13913.6 ELR21709.1 - 0.35 10.8 11.3 4.2 7.4 0.3 3.7 3 0 0 3 3 3 0 zinc-finger of a C2HC-type Elf1 PF05129.13 ELR21709.1 - 0.47 10.5 2.6 80 3.4 0.1 3.5 3 0 0 3 3 3 0 Transcription elongation factor Elf1 like zf-H2C2_2 PF13465.6 ELR21709.1 - 0.85 10.2 7.4 30 5.3 0.2 3.4 3 0 0 3 3 3 0 Zinc-finger double domain Prim_Zn_Ribbon PF08273.12 ELR21709.1 - 1.1 9.6 9.3 20 5.5 0.1 3.7 3 0 0 3 3 3 0 Zinc-binding domain of primase-helicase zf-FPG_IleRS PF06827.14 ELR21709.1 - 1.2 9.1 6.9 14 5.7 0.1 3.4 3 0 0 3 3 3 0 Zinc finger found in FPG and IleRS Ogr_Delta PF04606.12 ELR21709.1 - 3.8 7.6 8.1 8.3 6.5 0.2 3.4 3 0 0 3 3 3 0 Ogr/Delta-like zinc finger zf-ribbon_3 PF13248.6 ELR21709.1 - 4.4 6.8 21.8 2.2 7.8 0.2 5.0 6 0 0 6 6 6 0 zinc-ribbon domain LicD PF04991.13 ELR21710.1 - 1.2e-05 25.6 0.0 0.0005 20.3 0.0 2.1 2 0 0 2 2 2 2 LicD family Ras PF00071.22 ELR21711.1 - 1.5e-27 96.2 0.0 1.9e-27 95.8 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR21711.1 - 4.7e-16 59.1 0.1 8.1e-16 58.3 0.1 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ish1 PF10281.9 ELR21711.1 - 0.024 14.9 0.0 0.048 14.0 0.0 1.4 1 0 0 1 1 1 0 Putative stress-responsive nuclear envelope protein RRM_1 PF00076.22 ELR21712.1 - 2.1e-21 75.5 0.1 1.1e-09 38.0 0.1 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) BRAP2 PF07576.12 ELR21712.1 - 0.0016 18.6 0.0 0.0029 17.8 0.0 1.5 1 0 0 1 1 1 1 BRCA1-associated protein 2 RRM_7 PF16367.5 ELR21712.1 - 0.01 15.9 0.0 2.2 8.5 0.0 2.6 2 0 0 2 2 2 0 RNA recognition motif PHM7_cyt PF14703.6 ELR21712.1 - 0.03 14.5 0.1 4.3 7.5 0.0 2.9 2 1 1 3 3 3 0 Cytosolic domain of 10TM putative phosphate transporter ABM PF03992.16 ELR21712.1 - 0.11 12.6 0.1 1.5 9.0 0.1 2.3 2 0 0 2 2 2 0 Antibiotic biosynthesis monooxygenase SRP14 PF02290.15 ELR21713.1 - 1.1e-22 80.1 0.1 1.8e-22 79.5 0.1 1.3 1 0 0 1 1 1 1 Signal recognition particle 14kD protein SRP9-21 PF05486.12 ELR21713.1 - 0.04 14.3 1.0 0.049 14.0 0.8 1.4 1 1 0 1 1 1 0 Signal recognition particle 9 kDa protein (SRP9) Ras PF00071.22 ELR21714.1 - 1.6e-50 170.9 0.0 1.8e-50 170.7 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR21714.1 - 3.5e-24 85.3 0.0 5.4e-24 84.7 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR21714.1 - 2.2e-09 37.0 0.0 2.6e-09 36.8 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 ELR21714.1 - 0.0017 18.0 0.0 0.0043 16.6 0.0 1.6 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 ELR21714.1 - 0.0028 17.6 0.0 0.034 14.0 0.0 2.0 2 0 0 2 2 2 1 RsgA GTPase Gtr1_RagA PF04670.12 ELR21714.1 - 0.14 11.5 0.0 0.36 10.2 0.0 1.8 1 1 0 1 1 1 0 Gtr1/RagA G protein conserved region DUF2039 PF10217.9 ELR21715.1 - 9.2e-27 93.2 5.1 1.5e-26 92.5 5.1 1.2 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2039) Sigma70_r4_2 PF08281.12 ELR21715.1 - 0.0056 16.3 1.2 0.019 14.7 0.3 2.0 2 0 0 2 2 2 1 Sigma-70, region 4 Cytochrom_CIII PF02085.16 ELR21715.1 - 0.0073 16.6 1.9 0.013 15.8 1.9 1.4 1 0 0 1 1 1 1 Class III cytochrome C family zinc-ribbons_6 PF07191.12 ELR21715.1 - 0.055 13.4 7.8 0.99 9.4 4.0 2.1 1 1 0 2 2 2 0 zinc-ribbons DZR PF12773.7 ELR21715.1 - 0.15 12.1 6.2 0.92 9.6 6.2 2.1 1 1 1 2 2 2 0 Double zinc ribbon HypA PF01155.19 ELR21715.1 - 0.53 10.3 3.2 0.31 11.1 0.8 1.7 1 1 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Voldacs PF03517.13 ELR21715.1 - 5.6 7.1 11.9 16 5.7 11.9 1.7 1 1 1 2 2 2 0 Regulator of volume decrease after cellular swelling Lipase_GDSL PF00657.22 ELR21716.1 - 2e-05 24.7 0.7 0.0077 16.2 0.6 2.9 2 1 0 2 2 2 1 GDSL-like Lipase/Acylhydrolase Lipase_GDSL_2 PF13472.6 ELR21716.1 - 0.053 13.9 1.2 0.84 10.0 1.2 2.4 1 1 0 1 1 1 0 GDSL-like Lipase/Acylhydrolase family UAA PF08449.11 ELR21717.1 - 4.1e-19 68.9 7.9 4.6e-19 68.7 7.9 1.0 1 0 0 1 1 1 1 UAA transporter family EamA PF00892.20 ELR21717.1 - 2e-07 31.3 11.7 2.8e-07 30.8 11.7 1.2 1 0 0 1 1 1 1 EamA-like transporter family TPT PF03151.16 ELR21717.1 - 0.00012 21.6 1.4 0.00014 21.3 1.4 1.1 1 0 0 1 1 1 1 Triose-phosphate Transporter family UAA PF08449.11 ELR21718.1 - 3.4e-38 131.5 0.4 4.2e-38 131.3 0.4 1.0 1 0 0 1 1 1 1 UAA transporter family EamA PF00892.20 ELR21718.1 - 8.8e-08 32.4 3.2 8.8e-08 32.4 3.2 2.4 2 1 1 3 3 3 1 EamA-like transporter family TPT PF03151.16 ELR21718.1 - 0.0016 17.9 0.5 0.002 17.5 0.5 1.1 1 0 0 1 1 1 1 Triose-phosphate Transporter family DUF4271 PF14093.6 ELR21718.1 - 0.15 11.9 6.9 0.11 12.4 2.5 2.3 2 1 0 2 2 2 0 Domain of unknown function (DUF4271) Ist1 PF03398.14 ELR21719.1 - 3.7e-40 137.5 6.7 4.6e-40 137.2 6.7 1.1 1 0 0 1 1 1 1 Regulator of Vps4 activity in the MVB pathway Ras PF00071.22 ELR21720.1 - 1.4e-50 171.1 0.1 1.7e-50 170.8 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR21720.1 - 2.8e-19 69.5 0.2 8.6e-19 67.9 0.0 1.9 3 0 0 3 3 3 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR21720.1 - 2e-08 33.9 0.0 2.8e-08 33.4 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 ELR21720.1 - 2.8e-05 23.8 0.1 0.00013 21.6 0.0 1.8 1 1 0 2 2 2 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 ELR21720.1 - 0.0005 20.0 0.0 0.86 9.5 0.0 2.3 2 0 0 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 ELR21720.1 - 0.0048 17.0 0.0 0.011 15.8 0.0 1.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase AIG1 PF04548.16 ELR21720.1 - 0.054 12.8 0.1 0.11 11.8 0.0 1.5 2 0 0 2 2 2 0 AIG1 family MMR_HSR1_Xtn PF16897.5 ELR21720.1 - 0.072 13.1 0.2 0.14 12.2 0.0 1.6 2 0 0 2 2 2 0 C-terminal region of MMR_HSR1 domain STAT2_C PF12188.8 ELR21720.1 - 0.13 12.2 0.0 0.3 11.0 0.0 1.6 1 0 0 1 1 1 0 Signal transducer and activator of transcription 2 C terminal IstB_IS21 PF01695.17 ELR21720.1 - 0.2 11.3 0.4 2.6 7.8 0.1 2.1 1 1 1 2 2 2 0 IstB-like ATP binding protein HATPase_c PF02518.26 ELR21721.1 - 2.6e-29 102.0 0.1 4.6e-29 101.2 0.1 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 ELR21721.1 - 4.3e-24 84.8 0.1 7.5e-24 84.1 0.1 1.4 1 0 0 1 1 1 1 Response regulator receiver domain HisKA PF00512.25 ELR21721.1 - 1.3e-15 57.2 0.2 2.5e-15 56.2 0.2 1.5 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain HPTransfase PF10090.9 ELR21721.1 - 0.066 13.0 0.0 0.16 11.8 0.0 1.6 1 0 0 1 1 1 0 Histidine phosphotransferase C-terminal domain HATPase_c_3 PF13589.6 ELR21721.1 - 0.066 13.0 0.0 0.13 12.1 0.0 1.5 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Gelsolin PF00626.22 ELR21722.1 - 1.7e-42 143.2 4.9 2.5e-08 33.7 0.0 7.4 6 2 0 6 6 6 6 Gelsolin repeat TFIIA PF03153.13 ELR21722.1 - 0.14 12.2 8.4 0.19 11.7 8.4 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF1189 PF06691.11 ELR21722.1 - 4.5 6.8 4.4 7.7 6.0 4.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1189) Ras PF00071.22 ELR21724.1 - 1.4e-58 197.1 0.1 1.6e-58 196.9 0.1 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR21724.1 - 1.7e-33 115.4 0.0 2.4e-33 114.9 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR21724.1 - 6.8e-19 68.0 0.1 7.8e-19 67.8 0.1 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 ELR21724.1 - 3e-08 33.3 0.1 3.8e-08 33.0 0.1 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 ELR21724.1 - 3.7e-06 27.0 0.0 5.7e-06 26.4 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.10 ELR21724.1 - 1.3e-05 24.7 0.0 1.9e-05 24.2 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit RsgA_GTPase PF03193.16 ELR21724.1 - 6e-05 23.0 0.3 0.069 13.1 0.0 2.2 1 1 1 2 2 2 2 RsgA GTPase GTP_EFTU PF00009.27 ELR21724.1 - 0.00027 20.5 0.2 0.00085 18.9 0.2 1.9 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain ATP_bind_1 PF03029.17 ELR21724.1 - 0.00068 19.5 0.3 0.0065 16.3 0.0 1.9 1 1 1 2 2 2 1 Conserved hypothetical ATP binding protein PduV-EutP PF10662.9 ELR21724.1 - 0.04 13.7 0.0 0.087 12.6 0.0 1.5 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation AAA_16 PF13191.6 ELR21724.1 - 0.067 13.6 0.1 0.14 12.6 0.1 1.5 1 1 0 1 1 1 0 AAA ATPase domain AAA_29 PF13555.6 ELR21724.1 - 0.14 11.9 0.3 0.58 9.9 0.1 2.1 3 0 0 3 3 3 0 P-loop containing region of AAA domain DUF563 PF04577.14 ELR21725.1 - 1.4e-17 64.6 0.5 4.1e-17 63.0 0.5 1.8 1 1 0 1 1 1 1 Protein of unknown function (DUF563) NifT PF06988.11 ELR21725.1 - 0.033 14.0 0.0 5.2 6.9 0.0 2.5 2 0 0 2 2 2 0 NifT/FixU protein EcKinase PF02958.20 ELR21726.1 - 1.8e-14 53.8 0.0 3e-08 33.3 0.0 2.6 2 1 0 2 2 2 2 Ecdysteroid kinase APH PF01636.23 ELR21726.1 - 9.6e-08 32.2 0.4 2.5e-07 30.9 0.4 1.7 1 1 0 1 1 1 1 Phosphotransferase enzyme family DUF1679 PF07914.11 ELR21726.1 - 2.5e-05 23.3 0.0 4.7e-05 22.4 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1679) WD40 PF00400.32 ELR21727.1 - 2.3e-29 101.0 21.9 3.1e-06 27.8 0.6 6.9 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ELR21727.1 - 1e-08 35.4 0.2 0.0015 18.8 0.0 3.7 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ELR21727.1 - 4.5e-05 22.3 3.0 0.8 8.3 0.0 4.2 2 2 2 4 4 4 3 Nucleoporin Nup120/160 F-box PF00646.33 ELR21727.1 - 0.00028 20.7 0.0 0.00062 19.6 0.0 1.6 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 ELR21727.1 - 0.00087 19.1 0.0 0.0026 17.6 0.0 1.9 2 0 0 2 2 2 1 F-box-like Nucleoporin_N PF08801.11 ELR21727.1 - 0.024 13.4 0.1 0.57 8.9 0.0 2.5 1 1 2 3 3 3 0 Nup133 N terminal like WD40_like PF17005.5 ELR21727.1 - 0.051 12.9 0.0 0.5 9.6 0.0 2.4 3 0 0 3 3 3 0 WD40-like domain Acyl-CoA_dh_1 PF00441.24 ELR21728.1 - 3e-46 157.3 0.6 4.6e-46 156.7 0.1 1.6 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.16 ELR21728.1 - 2.4e-29 102.3 0.1 5.2e-29 101.2 0.1 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.19 ELR21728.1 - 9.7e-25 86.6 0.0 2.2e-24 85.4 0.0 1.7 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.11 ELR21728.1 - 9.1e-22 77.8 0.1 4.6e-21 75.5 0.0 2.1 3 0 0 3 3 3 1 Acyl-CoA dehydrogenase, C-terminal domain RasGEF PF00617.19 ELR21729.1 - 3.2e-56 190.3 0.0 5.8e-56 189.5 0.0 1.4 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 ELR21729.1 - 1.2e-12 47.9 0.0 3.4e-09 36.9 0.0 2.6 2 0 0 2 2 2 2 RasGEF N-terminal motif F-box-like PF12937.7 ELR21729.1 - 0.00041 20.2 0.7 0.00096 19.0 0.7 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ELR21729.1 - 0.01 15.7 0.7 0.025 14.5 0.7 1.7 1 0 0 1 1 1 0 F-box domain zf-RanBP PF00641.18 ELR21729.1 - 0.013 14.8 2.7 0.027 13.8 2.7 1.5 1 0 0 1 1 1 0 Zn-finger in Ran binding protein and others CAP_N PF01213.19 ELR21729.1 - 0.49 9.8 5.1 1.2 8.6 5.1 1.6 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal DUF455 PF04305.14 ELR21730.1 - 6.2e-82 274.9 0.0 7e-82 274.7 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF455) Ferritin PF00210.24 ELR21730.1 - 0.069 13.1 0.0 0.15 12.0 0.0 1.6 1 1 0 1 1 1 0 Ferritin-like domain CAF1C_H4-bd PF12265.8 ELR21731.1 - 5e-31 106.8 0.5 5e-31 106.8 0.5 2.7 3 1 0 3 3 3 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex WD40 PF00400.32 ELR21731.1 - 1.8e-23 82.3 9.3 1.6e-06 28.7 0.0 5.7 5 0 0 5 5 5 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ELR21731.1 - 2.9e-05 24.3 3.2 0.12 12.7 0.1 4.5 3 1 2 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 ELR21731.1 - 0.00065 19.6 0.4 0.0027 17.6 0.0 2.2 3 0 0 3 3 3 1 Eukaryotic translation initiation factor eIF2A Phosphorylase PF00343.20 ELR21734.1 - 0 1025.8 0.0 0 1025.5 0.0 1.0 1 0 0 1 1 1 1 Carbohydrate phosphorylase MFS_1 PF07690.16 ELR21735.1 - 2.1e-27 96.0 21.6 2.8e-27 95.6 21.6 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 ELR21735.1 - 4.4e-06 25.8 8.2 4.4e-06 25.8 8.2 2.1 2 0 0 2 2 2 1 Sugar (and other) transporter Phage-Gp8 PF09215.10 ELR21736.1 - 0.004 16.3 0.4 0.0063 15.6 0.4 1.2 1 0 0 1 1 1 1 Bacteriophage T4, Gp8 Vault_2 PF17794.1 ELR21737.1 - 4.2e-21 75.1 0.2 1.2e-20 73.6 0.0 1.7 2 0 0 2 2 2 1 Major Vault Protein repeat domain Vault_3 PF17795.1 ELR21737.1 - 0.0045 17.0 1.0 0.98 9.5 0.0 2.2 1 1 1 2 2 2 2 Major Vault Protein Repeat domain SH3_1 PF00018.28 ELR21739.1 - 6e-17 61.0 0.1 2.4e-16 59.1 0.0 2.0 2 0 0 2 2 2 1 SH3 domain SH3_9 PF14604.6 ELR21739.1 - 4.1e-13 49.0 0.0 7.2e-13 48.2 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 ELR21739.1 - 2.3e-11 43.2 0.0 6.1e-11 41.8 0.0 1.8 2 0 0 2 2 2 1 Variant SH3 domain EF-hand_1 PF00036.32 ELR21740.1 - 3.1e-21 73.3 6.6 1.5e-06 27.3 0.0 3.3 3 0 0 3 3 3 3 EF hand EF-hand_7 PF13499.6 ELR21740.1 - 2.2e-19 69.7 4.1 4.1e-15 56.0 1.8 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 ELR21740.1 - 3.8e-17 60.9 7.6 1.7e-08 33.6 0.1 3.3 3 0 0 3 3 3 3 EF hand EF-hand_6 PF13405.6 ELR21740.1 - 5.3e-17 60.2 6.7 8e-06 25.4 0.2 3.4 3 0 0 3 3 3 3 EF-hand domain EF-hand_8 PF13833.6 ELR21740.1 - 6.2e-09 35.6 8.0 4.8e-05 23.1 0.4 3.4 1 1 2 3 3 3 3 EF-hand domain pair SPARC_Ca_bdg PF10591.9 ELR21740.1 - 2e-05 24.9 0.1 0.046 14.1 0.0 2.9 2 1 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 ELR21740.1 - 0.0022 17.9 3.3 2 8.4 0.2 3.1 1 1 2 3 3 3 2 Cytoskeletal-regulatory complex EF hand Dockerin_1 PF00404.18 ELR21740.1 - 0.011 15.9 2.9 0.35 11.1 2.5 2.5 1 1 1 2 2 2 0 Dockerin type I domain DUF1707 PF08044.11 ELR21740.1 - 0.015 15.4 0.6 6.8 6.9 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF1707) MIT PF04212.18 ELR21742.1 - 5.4e-23 80.8 13.6 1.2e-13 50.9 3.3 3.3 3 0 0 3 3 3 3 MIT (microtubule interacting and transport) domain Arrestin_C PF02752.22 ELR21742.1 - 6.9e-13 49.2 1.0 3.1e-12 47.1 0.4 2.2 2 0 0 2 2 2 1 Arrestin (or S-antigen), C-terminal domain SR-25 PF10500.9 ELR21742.1 - 0.066 12.8 9.4 1.1 8.8 3.9 2.5 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein TPR_1 PF00515.28 ELR21742.1 - 0.31 10.9 3.6 0.87 9.5 0.2 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_2 PF07719.17 ELR21742.1 - 1 9.6 3.6 12 6.4 0.6 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat Cellulase PF00150.18 ELR21743.1 - 2.4e-43 148.6 0.3 3.2e-43 148.2 0.3 1.1 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) KASH PF10541.9 ELR21743.1 - 0.16 12.2 0.3 0.41 11.0 0.3 1.6 1 0 0 1 1 1 0 Nuclear envelope localisation domain DUF563 PF04577.14 ELR21744.1 - 1.3e-17 64.6 0.0 2e-16 60.7 0.0 2.1 1 1 0 1 1 1 1 Protein of unknown function (DUF563) FR47 PF08445.10 ELR21746.1 - 0.037 14.0 0.0 0.091 12.7 0.0 1.6 2 0 0 2 2 2 0 FR47-like protein Acetyltransf_1 PF00583.25 ELR21746.1 - 0.093 13.0 0.0 0.17 12.1 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family Ras PF00071.22 ELR21747.1 - 3.3e-39 134.1 0.1 4.3e-39 133.7 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR21747.1 - 5.7e-11 42.7 0.1 2.3e-10 40.7 0.0 1.8 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR21747.1 - 3.6e-07 29.8 0.0 4.3e-07 29.6 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 ELR21747.1 - 4.2e-06 26.5 0.1 4.7e-06 26.3 0.1 1.1 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain ATP_bind_1 PF03029.17 ELR21747.1 - 0.011 15.5 0.0 0.013 15.3 0.0 1.1 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein Gtr1_RagA PF04670.12 ELR21747.1 - 0.029 13.7 0.3 0.037 13.4 0.3 1.1 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region 3HCDH_N PF02737.18 ELR21748.1 - 1.2e-58 198.0 5.0 1.4e-58 197.7 5.0 1.1 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 3HCDH PF00725.22 ELR21748.1 - 4.5e-33 113.7 0.0 1e-32 112.6 0.0 1.6 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain TrkA_N PF02254.18 ELR21748.1 - 0.0021 18.3 1.2 0.0047 17.2 0.9 1.8 2 0 0 2 2 2 1 TrkA-N domain 2-Hacid_dh_C PF02826.19 ELR21748.1 - 0.0034 16.8 1.1 0.0063 15.9 1.1 1.5 1 1 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_binding_2 PF03446.15 ELR21748.1 - 0.0039 17.4 0.7 0.0072 16.5 0.7 1.5 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase Sacchrp_dh_NADP PF03435.18 ELR21748.1 - 0.0041 17.4 1.0 0.0068 16.7 1.0 1.3 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain DUF3479 PF11965.8 ELR21748.1 - 0.013 15.6 1.1 0.023 14.8 1.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3479) ApbA PF02558.16 ELR21748.1 - 0.092 12.4 2.2 0.25 11.0 1.4 2.0 2 1 0 2 2 2 0 Ketopantoate reductase PanE/ApbA Ldh_1_N PF00056.23 ELR21748.1 - 0.3 11.2 2.4 0.56 10.3 2.4 1.5 1 1 0 1 1 1 0 lactate/malate dehydrogenase, NAD binding domain DapB_N PF01113.20 ELR21748.1 - 0.83 9.8 4.1 2.2 8.4 4.1 1.7 1 1 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus Arrestin_N PF00339.29 ELR21749.1 - 3.7e-15 56.3 0.4 3.9e-12 46.4 0.1 3.0 2 1 1 3 3 3 1 Arrestin (or S-antigen), N-terminal domain Arrestin_C PF02752.22 ELR21749.1 - 1.3e-11 45.1 0.0 9e-11 42.4 0.0 2.3 3 1 0 3 3 3 1 Arrestin (or S-antigen), C-terminal domain Rgp1 PF08737.10 ELR21749.1 - 9.6e-06 25.0 0.2 0.19 10.9 0.1 2.7 1 1 2 3 3 3 2 Rgp1 Spo0M PF07070.11 ELR21749.1 - 0.00074 19.1 0.1 0.052 13.1 0.1 2.4 2 1 0 2 2 2 1 SpoOM protein MG2 PF01835.19 ELR21749.1 - 0.035 14.5 0.1 0.15 12.6 0.0 2.0 2 0 0 2 2 2 0 MG2 domain SYCP2_SLD PF18584.1 ELR21749.1 - 0.078 13.2 0.0 0.18 12.1 0.0 1.6 1 0 0 1 1 1 0 Synaptonemal complex 2 Spt16M-like domain Isochorismatase PF00857.20 ELR21750.1 - 1e-43 149.6 0.2 1.2e-43 149.4 0.2 1.1 1 0 0 1 1 1 1 Isochorismatase family Pkinase_Tyr PF07714.17 ELR21751.1 - 1.5e-51 175.2 0.0 2.5e-51 174.5 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ELR21751.1 - 1.2e-39 136.3 0.0 1.9e-39 135.7 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain COR PF16095.5 ELR21751.1 - 2.2e-25 89.6 0.0 3.7e-16 59.5 0.0 2.4 2 0 0 2 2 2 2 C-terminal of Roc, COR, domain LRR_4 PF12799.7 ELR21751.1 - 1.4e-16 60.3 47.3 1.4e-06 28.5 0.9 9.4 9 1 1 10 10 9 5 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 ELR21751.1 - 3.9e-16 58.6 45.9 3.1e-08 33.2 0.7 8.5 6 3 2 8 8 8 4 Leucine rich repeat WD40 PF00400.32 ELR21751.1 - 1.6e-07 31.8 14.4 0.014 16.3 0.4 4.3 3 0 0 3 3 3 3 WD domain, G-beta repeat LRR_6 PF13516.6 ELR21751.1 - 1.8e-07 30.7 50.8 0.00064 19.6 0.8 11.9 13 0 0 13 13 13 5 Leucine Rich repeat Roc PF08477.13 ELR21751.1 - 6.4e-06 26.4 0.0 7.4e-05 22.9 0.0 2.5 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase PQQ_3 PF13570.6 ELR21751.1 - 2e-05 24.9 6.9 0.062 13.8 0.1 5.8 6 0 0 6 6 6 2 PQQ-like domain LRR_9 PF14580.6 ELR21751.1 - 0.014 14.9 3.2 0.032 13.8 0.6 2.8 2 1 0 3 3 3 0 Leucine-rich repeat LRR_1 PF00560.33 ELR21751.1 - 0.051 14.1 36.6 7.4 7.5 0.2 11.8 10 2 0 10 10 9 0 Leucine Rich Repeat cobW PF02492.19 ELR21752.1 - 7.3e-29 100.6 0.0 9.2e-29 100.3 0.0 1.1 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain MobB PF03205.14 ELR21752.1 - 3.9e-05 23.6 0.0 5.7e-05 23.0 0.0 1.2 1 0 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B AAA_22 PF13401.6 ELR21752.1 - 0.00087 19.6 0.1 0.0014 18.9 0.1 1.5 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 ELR21752.1 - 0.0013 19.2 0.1 0.0018 18.7 0.1 1.4 1 1 0 1 1 1 1 AAA ATPase domain AAA_18 PF13238.6 ELR21752.1 - 0.0015 19.1 0.0 0.0027 18.3 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 ELR21752.1 - 0.003 17.7 0.1 0.0039 17.3 0.1 1.5 1 1 0 1 1 1 1 AAA domain TsaE PF02367.17 ELR21752.1 - 0.0044 17.0 0.0 0.0076 16.2 0.0 1.3 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_30 PF13604.6 ELR21752.1 - 0.0099 15.6 0.0 0.012 15.3 0.0 1.2 1 0 0 1 1 1 1 AAA domain MeaB PF03308.16 ELR21752.1 - 0.01 14.8 0.0 0.016 14.2 0.0 1.3 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_28 PF13521.6 ELR21752.1 - 0.02 15.2 0.2 0.039 14.2 0.2 1.4 1 1 0 1 1 1 0 AAA domain NACHT PF05729.12 ELR21752.1 - 0.022 14.7 0.0 0.038 13.9 0.0 1.3 1 0 0 1 1 1 0 NACHT domain Viral_helicase1 PF01443.18 ELR21752.1 - 0.024 14.4 0.0 0.04 13.7 0.0 1.4 1 1 0 1 1 1 0 Viral (Superfamily 1) RNA helicase AAA_14 PF13173.6 ELR21752.1 - 0.034 14.2 0.1 0.078 13.0 0.1 1.7 1 1 0 1 1 1 0 AAA domain SRP54 PF00448.22 ELR21752.1 - 0.04 13.5 0.3 0.18 11.4 0.3 1.8 1 1 0 1 1 1 0 SRP54-type protein, GTPase domain AAA_29 PF13555.6 ELR21752.1 - 0.076 12.8 0.0 0.14 11.9 0.0 1.3 1 0 0 1 1 1 0 P-loop containing region of AAA domain T2SSE PF00437.20 ELR21752.1 - 0.077 12.0 0.0 0.1 11.6 0.0 1.2 1 0 0 1 1 1 0 Type II/IV secretion system protein SRPRB PF09439.10 ELR21752.1 - 0.095 12.1 0.0 0.13 11.7 0.0 1.2 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit AAA_23 PF13476.6 ELR21752.1 - 0.12 12.9 0.1 0.19 12.2 0.1 1.3 1 0 0 1 1 1 0 AAA domain Roc PF08477.13 ELR21752.1 - 0.13 12.5 0.0 0.23 11.7 0.0 1.4 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase ATPase_2 PF01637.18 ELR21752.1 - 0.14 12.1 0.0 0.17 11.8 0.0 1.2 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea NTPase_1 PF03266.15 ELR21752.1 - 0.17 11.8 0.1 0.25 11.3 0.1 1.4 1 1 0 1 1 1 0 NTPase Zeta_toxin PF06414.12 ELR21752.1 - 0.17 11.1 0.0 0.4 9.9 0.0 1.6 1 0 0 1 1 1 0 Zeta toxin MMR_HSR1 PF01926.23 ELR21752.1 - 0.19 11.8 0.0 0.26 11.4 0.0 1.4 1 1 0 1 1 1 0 50S ribosome-binding GTPase CobW_C PF07683.14 ELR21753.1 - 9.3e-12 44.7 0.1 1.6e-11 43.9 0.1 1.4 1 0 0 1 1 1 1 Cobalamin synthesis protein cobW C-terminal domain Zip PF02535.22 ELR21754.1 - 2.5e-19 69.7 2.9 3.2e-18 66.0 0.9 2.0 1 1 1 2 2 2 2 ZIP Zinc transporter Methyltransf_25 PF13649.6 ELR21755.1 - 0.00013 22.6 0.0 0.00019 22.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain UPF0020 PF01170.18 ELR21755.1 - 0.00026 20.7 0.0 0.00036 20.3 0.0 1.2 1 0 0 1 1 1 1 Putative RNA methylase family UPF0020 Methyltransf_11 PF08241.12 ELR21755.1 - 0.00037 21.1 0.0 0.00061 20.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 ELR21755.1 - 0.0094 15.3 0.0 0.01 15.1 0.0 1.1 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_31 PF13847.6 ELR21755.1 - 0.015 15.1 0.0 0.015 15.1 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain Pkinase PF00069.25 ELR21756.1 - 1.1e-73 247.9 0.0 1.4e-73 247.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR21756.1 - 2.6e-38 131.8 0.0 3.4e-38 131.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_C PF00433.24 ELR21756.1 - 3.7e-08 33.9 0.9 3.7e-08 33.9 0.9 1.8 2 0 0 2 2 2 1 Protein kinase C terminal domain Kinase-like PF14531.6 ELR21756.1 - 1.2e-05 24.8 0.2 0.02 14.2 0.0 2.9 2 1 1 3 3 3 2 Kinase-like PH PF00169.29 ELR21756.1 - 2.2e-05 24.9 0.1 4.5e-05 23.9 0.1 1.5 1 0 0 1 1 1 1 PH domain PH_9 PF15410.6 ELR21756.1 - 0.00021 21.6 0.3 0.00021 21.6 0.3 2.2 2 0 0 2 2 2 1 Pleckstrin homology domain PH_3 PF14593.6 ELR21756.1 - 0.007 16.5 0.2 0.018 15.1 0.2 1.7 1 0 0 1 1 1 1 PH domain PH_13 PF16652.5 ELR21756.1 - 0.035 13.9 0.3 0.07 12.9 0.3 1.4 1 0 0 1 1 1 0 Pleckstrin homology domain PCM1_C PF15717.5 ELR21756.1 - 0.04 12.6 1.5 0.051 12.3 1.5 1.1 1 0 0 1 1 1 0 Pericentriolar material 1 C terminus SR-25 PF10500.9 ELR21756.1 - 0.06 12.9 3.5 0.08 12.5 3.5 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Pkinase_fungal PF17667.1 ELR21756.1 - 0.079 11.7 0.0 0.22 10.3 0.0 1.6 2 0 0 2 2 2 0 Fungal protein kinase FTA2 PF13095.6 ELR21756.1 - 0.09 12.4 0.0 9.1 5.8 0.0 2.3 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 GRP PF07172.11 ELR21757.1 - 0.0056 17.4 5.7 0.0088 16.7 5.7 1.2 1 0 0 1 1 1 1 Glycine rich protein family CorA PF01544.18 ELR21757.1 - 0.013 14.8 0.7 0.019 14.3 0.0 1.5 2 0 0 2 2 2 0 CorA-like Mg2+ transporter protein DUF2682 PF10909.8 ELR21757.1 - 2.2 8.8 7.8 0.46 11.0 0.6 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF2682) Pkinase PF00069.25 ELR21758.1 - 0.0018 17.7 0.0 0.0021 17.5 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain HMG_box PF00505.19 ELR21759.1 - 8.8e-24 83.7 3.5 1.9e-23 82.6 3.5 1.6 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 ELR21759.1 - 1.2e-18 67.5 2.8 1.2e-18 67.5 2.8 1.6 2 0 0 2 2 2 1 HMG-box domain HMG_box_5 PF14887.6 ELR21759.1 - 0.055 13.4 10.8 0.035 14.1 9.1 1.7 1 1 0 1 1 1 0 HMG (high mobility group) box 5 nos_propeller_2 PF18793.1 ELR21759.1 - 0.09 13.1 0.0 0.16 12.3 0.0 1.4 1 0 0 1 1 1 0 Nitrous oxide reductase propeller repeat 2 Cwf_Cwc_15 PF04889.12 ELR21759.1 - 6.2 6.5 23.7 8.6 6.0 23.7 1.3 1 1 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein RR_TM4-6 PF06459.12 ELR21759.1 - 6.7 6.4 14.7 12 5.7 14.7 1.5 1 1 0 1 1 1 0 Ryanodine Receptor TM 4-6 RasGEF PF00617.19 ELR21760.1 - 4.4e-50 170.3 0.3 9.5e-50 169.2 0.3 1.6 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 ELR21760.1 - 2.8e-23 82.2 0.0 6.5e-23 81.0 0.0 1.7 1 0 0 1 1 1 1 RasGEF N-terminal motif FERM_f0 PF16511.5 ELR21760.1 - 4.2e-20 71.8 0.1 1.9e-09 37.7 0.1 5.3 5 0 0 5 5 5 3 N-terminal or F0 domain of Talin-head FERM LRR_8 PF13855.6 ELR21761.1 - 8.6e-21 73.5 25.8 4.2e-10 39.2 1.6 5.5 2 2 4 6 6 6 5 Leucine rich repeat LRR_4 PF12799.7 ELR21761.1 - 3.2e-13 49.6 30.7 9.5e-05 22.7 2.1 6.3 1 1 8 9 9 9 8 Leucine Rich repeats (2 copies) Drf_GBD PF06371.13 ELR21761.1 - 2.9e-09 36.7 0.0 7.8e-09 35.4 0.0 1.6 1 0 0 1 1 1 1 Diaphanous GTPase-binding Domain Drf_FH3 PF06367.16 ELR21761.1 - 3.2e-06 26.9 0.1 9.8e-06 25.3 0.1 1.8 1 0 0 1 1 1 1 Diaphanous FH3 Domain LRR_9 PF14580.6 ELR21761.1 - 8.8e-05 22.1 13.5 0.0035 16.9 1.3 3.7 1 1 2 3 3 3 2 Leucine-rich repeat CNDH2_C PF16858.5 ELR21761.1 - 0.034 14.0 0.5 0.034 14.0 0.5 2.5 2 0 0 2 2 2 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term LRR_1 PF00560.33 ELR21761.1 - 0.037 14.5 12.1 15 6.6 0.1 7.1 8 1 0 8 8 8 0 Leucine Rich Repeat SURF2 PF05477.11 ELR21761.1 - 0.39 10.4 7.7 1.1 8.9 2.8 2.5 2 0 0 2 2 2 0 Surfeit locus protein 2 (SURF2) eIF2_C PF09173.11 ELR21762.1 - 1.8e-36 124.3 0.6 4.8e-36 122.9 0.6 1.8 1 0 0 1 1 1 1 Initiation factor eIF2 gamma, C terminal GTP_EFTU PF00009.27 ELR21762.1 - 1.8e-21 76.6 2.5 1.2e-20 73.9 2.5 2.0 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D2 PF03144.25 ELR21762.1 - 3e-11 43.6 1.0 3e-11 43.6 1.0 1.9 2 0 0 2 2 2 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 ELR21762.1 - 0.0027 17.8 0.0 0.0063 16.6 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 ELR21762.1 - 0.0076 16.2 0.6 0.079 12.9 0.1 2.2 2 0 0 2 2 2 1 RsgA GTPase DDR_swiveling PF18427.1 ELR21762.1 - 0.017 15.2 0.7 0.038 14.0 0.7 1.5 1 0 0 1 1 1 0 DD-reactivating factor swiveling domain MMR_HSR1_Xtn PF16897.5 ELR21762.1 - 0.073 13.1 0.6 0.32 11.0 0.1 2.1 2 0 0 2 2 2 0 C-terminal region of MMR_HSR1 domain Dynamin_N PF00350.23 ELR21762.1 - 0.094 12.8 0.2 0.33 11.0 0.1 1.9 1 1 1 2 2 2 0 Dynamin family LRR_6 PF13516.6 ELR21763.1 - 7.5e-31 103.5 43.3 0.00015 21.6 0.1 14.0 15 0 0 15 15 15 8 Leucine Rich repeat UQ_con PF00179.26 ELR21763.1 - 2.1e-27 95.5 0.0 4.2e-27 94.5 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme LRR_4 PF12799.7 ELR21763.1 - 0.003 17.9 0.9 0.075 13.5 0.1 9.9 6 3 6 13 13 13 5 Leucine Rich repeats (2 copies) RRM_1 PF00076.22 ELR21763.1 - 0.0069 16.2 0.0 0.021 14.7 0.0 1.8 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Med15 PF09606.10 ELR21763.1 - 0.012 14.3 0.4 0.02 13.6 0.4 1.2 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal LRR_1 PF00560.33 ELR21763.1 - 0.2 12.3 18.3 65 4.7 0.0 9.9 13 1 0 13 13 13 0 Leucine Rich Repeat Rieske_2 PF13806.6 ELR21764.1 - 3e-09 36.7 0.0 3.9e-09 36.4 0.0 1.1 1 0 0 1 1 1 1 Rieske-like [2Fe-2S] domain Rieske PF00355.26 ELR21764.1 - 1.3e-08 34.7 0.7 2e-08 34.1 0.6 1.4 1 1 0 1 1 1 1 Rieske [2Fe-2S] domain Transketolase_N PF00456.21 ELR21765.1 - 1.2e-11 44.2 0.3 6.9e-09 35.1 0.0 2.5 3 0 0 3 3 3 2 Transketolase, thiamine diphosphate binding domain SUIM_assoc PF16619.5 ELR21766.1 - 0.98 9.5 6.6 45 4.2 0.4 3.5 3 1 0 3 3 3 0 Unstructured region C-term to UIM in Ataxin3 Skp1 PF01466.19 ELR21767.1 - 1.6e-23 82.5 6.9 1.5e-22 79.4 0.1 2.4 2 0 0 2 2 2 2 Skp1 family, dimerisation domain Skp1_POZ PF03931.15 ELR21767.1 - 5.6e-22 77.7 0.2 2e-21 75.9 0.1 1.9 2 0 0 2 2 2 1 Skp1 family, tetramerisation domain Fe-ADH PF00465.19 ELR21768.1 - 2.8e-102 342.2 0.1 3.7e-102 341.8 0.1 1.2 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase Fe-ADH_2 PF13685.6 ELR21768.1 - 7.7e-12 45.4 0.4 2.1e-07 30.9 0.0 2.2 2 0 0 2 2 2 2 Iron-containing alcohol dehydrogenase MerR-DNA-bind PF09278.11 ELR21768.1 - 0.06 13.9 0.0 0.16 12.6 0.0 1.7 1 1 0 1 1 1 0 MerR, DNA binding BAR_3 PF16746.5 ELR21769.1 - 2.1e-37 129.1 6.9 3.3e-37 128.5 6.9 1.3 1 0 0 1 1 1 1 BAR domain of APPL family ArfGap PF01412.18 ELR21769.1 - 7e-37 126.1 0.0 1.4e-36 125.1 0.0 1.5 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf PH PF00169.29 ELR21769.1 - 5.4e-15 55.8 0.1 9.8e-15 55.0 0.1 1.5 1 0 0 1 1 1 1 PH domain Ank_2 PF12796.7 ELR21769.1 - 3e-10 40.5 0.3 7.8e-10 39.2 0.1 1.9 2 0 0 2 2 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 ELR21769.1 - 8.5e-10 38.7 0.3 0.00016 21.9 0.1 2.5 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 ELR21769.1 - 2.1e-08 34.5 0.5 0.00013 22.5 0.0 2.9 1 1 2 3 3 3 2 Ankyrin repeats (many copies) BAR PF03114.18 ELR21769.1 - 6.8e-08 32.4 5.9 1.1e-07 31.7 5.9 1.3 1 0 0 1 1 1 1 BAR domain Ank_3 PF13606.6 ELR21769.1 - 2.3e-05 24.4 0.2 3.7 8.4 0.0 3.9 3 0 0 3 3 3 2 Ankyrin repeat SHE3 PF17078.5 ELR21769.1 - 0.00036 20.3 1.5 0.0006 19.6 1.5 1.3 1 0 0 1 1 1 1 SWI5-dependent HO expression protein 3 PH_11 PF15413.6 ELR21769.1 - 0.00041 20.7 3.5 0.034 14.6 1.3 2.7 2 0 0 2 2 2 1 Pleckstrin homology domain PSD4 PF07631.11 ELR21769.1 - 0.032 14.8 1.1 5.8 7.5 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1592) PH_9 PF15410.6 ELR21769.1 - 0.099 13.0 1.0 5.1 7.5 1.0 2.5 1 1 0 1 1 1 0 Pleckstrin homology domain PH_13 PF16652.5 ELR21769.1 - 0.11 12.3 0.2 0.27 11.0 0.0 1.7 2 0 0 2 2 2 0 Pleckstrin homology domain Ank PF00023.30 ELR21769.1 - 0.12 12.9 6.1 2 9.0 0.1 3.7 4 0 0 4 4 3 0 Ankyrin repeat Arfaptin PF06456.13 ELR21769.1 - 0.75 9.3 7.5 0.56 9.7 4.7 2.2 2 1 0 2 2 2 0 Arfaptin-like domain PPR PF01535.20 ELR21770.1 - 5.2e-37 123.5 0.6 3.9e-07 29.9 0.0 10.4 11 0 0 11 11 11 7 PPR repeat DYW_deaminase PF14432.6 ELR21770.1 - 4.7e-36 123.5 0.1 9.6e-36 122.5 0.1 1.6 1 0 0 1 1 1 1 DYW family of nucleic acid deaminases PPR_2 PF13041.6 ELR21770.1 - 2.9e-25 88.2 0.0 0.00036 20.7 0.0 9.3 7 3 2 9 9 9 5 PPR repeat family PPR_1 PF12854.7 ELR21770.1 - 3.8e-22 77.7 1.7 0.003 17.2 0.0 8.8 8 1 1 9 9 9 5 PPR repeat PPR_3 PF13812.6 ELR21770.1 - 2.6e-08 33.8 0.0 7 6.8 0.0 6.8 5 1 2 7 7 7 1 Pentatricopeptide repeat domain PPR_long PF17177.4 ELR21770.1 - 5.8e-08 32.3 0.4 0.031 13.7 0.2 3.8 2 2 0 2 2 2 2 Pentacotripeptide-repeat region of PRORP TPR_19 PF14559.6 ELR21770.1 - 4.3e-07 30.4 8.2 0.058 13.9 0.0 6.7 6 2 2 8 8 8 2 Tetratricopeptide repeat TPR_14 PF13428.6 ELR21770.1 - 0.00026 21.5 27.9 0.19 12.6 0.6 8.9 7 3 3 10 10 10 2 Tetratricopeptide repeat Zn-ribbon_8 PF09723.10 ELR21770.1 - 0.11 12.7 1.0 48 4.2 0.0 3.6 3 0 0 3 3 3 0 Zinc ribbon domain TPR_10 PF13374.6 ELR21770.1 - 0.27 11.2 7.4 17 5.4 0.0 5.7 7 0 0 7 7 7 0 Tetratricopeptide repeat EF-hand_6 PF13405.6 ELR21771.1 - 3.2e-17 60.9 0.1 5.2e-05 22.9 0.0 4.2 4 0 0 4 4 4 3 EF-hand domain EF-hand_7 PF13499.6 ELR21771.1 - 4.4e-16 59.1 0.0 5.1e-07 30.0 0.0 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 ELR21771.1 - 1.6e-14 52.2 0.6 0.00061 19.2 0.1 4.2 4 0 0 4 4 4 3 EF hand EF-hand_8 PF13833.6 ELR21771.1 - 3.2e-10 39.7 3.1 0.0021 17.8 0.0 3.8 2 1 2 4 4 4 4 EF-hand domain pair EF-hand_5 PF13202.6 ELR21771.1 - 5.4e-07 28.8 0.2 0.0063 16.0 0.0 3.2 3 0 0 3 3 3 2 EF hand EF-hand_9 PF14658.6 ELR21771.1 - 0.00089 19.5 0.0 0.062 13.6 0.0 2.3 2 0 0 2 2 2 1 EF-hand domain Dockerin_1 PF00404.18 ELR21771.1 - 0.0092 16.2 0.1 0.089 13.0 0.1 2.2 1 1 0 1 1 1 1 Dockerin type I domain EFhand_Ca_insen PF08726.10 ELR21771.1 - 0.14 12.3 0.1 3.5 7.8 0.0 2.5 3 0 0 3 3 3 0 Ca2+ insensitive EF hand SH3_1 PF00018.28 ELR21772.1 - 2.6e-11 42.9 0.0 5.2e-11 42.0 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 ELR21772.1 - 5.3e-11 42.0 0.0 9.5e-11 41.2 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.6 ELR21772.1 - 2e-10 40.4 0.0 3.5e-10 39.6 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain Rootletin PF15035.6 ELR21772.1 - 0.023 14.7 1.2 0.023 14.7 1.2 2.7 3 0 0 3 3 3 0 Ciliary rootlet component, centrosome cohesion TolA_bind_tri PF16331.5 ELR21772.1 - 0.044 13.9 4.7 1.1 9.4 0.9 2.7 2 0 0 2 2 2 0 TolA binding protein trimerisation Csm1_N PF18504.1 ELR21772.1 - 0.05 13.9 0.5 0.19 12.1 0.5 2.0 1 0 0 1 1 1 0 Csm1 N-terminal domain GAS PF13851.6 ELR21772.1 - 3.5 6.9 8.1 1 8.7 0.7 2.3 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding Prp19 PF08606.11 ELR21772.1 - 4.4 7.4 6.0 1 9.4 1.5 2.2 2 0 0 2 2 2 0 Prp19/Pso4-like SKA1 PF07160.12 ELR21772.1 - 6.3 6.6 8.1 1.3 8.8 3.9 1.9 2 0 0 2 2 2 0 Spindle and kinetochore-associated protein 1 KASH_CCD PF14662.6 ELR21772.1 - 7.1 6.4 14.4 0.43 10.4 0.4 2.5 3 0 0 3 3 3 0 Coiled-coil region of CCDC155 or KASH DivIC PF04977.15 ELR21772.1 - 7.4 6.4 6.3 1.6 8.6 2.0 2.1 2 0 0 2 2 2 0 Septum formation initiator Ank_4 PF13637.6 ELR21773.1 - 3.6e-40 135.8 15.1 1.1e-10 41.9 0.3 5.0 1 1 4 5 5 5 5 Ankyrin repeats (many copies) Ank_2 PF12796.7 ELR21773.1 - 1.7e-32 111.8 7.7 1.1e-19 70.8 0.4 2.8 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.30 ELR21773.1 - 6.2e-30 102.3 17.8 1.3e-08 34.9 0.3 6.2 6 0 0 6 6 6 4 Ankyrin repeat Ank_5 PF13857.6 ELR21773.1 - 5.6e-27 93.5 8.0 3e-10 40.1 1.1 3.8 1 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 ELR21773.1 - 6.9e-23 78.3 10.8 8.2e-06 25.8 0.1 6.5 7 0 0 7 7 5 4 Ankyrin repeat Bromodomain PF00439.25 ELR21773.1 - 2.3e-22 78.9 0.1 1e-20 73.6 0.0 3.0 3 0 0 3 3 3 1 Bromodomain BTB PF00651.31 ELR21773.1 - 1.7e-10 41.1 0.0 4.2e-10 39.8 0.0 1.7 1 1 0 1 1 1 1 BTB/POZ domain BET PF17035.5 ELR21773.1 - 2e-08 34.3 1.2 1.8e-06 28.0 0.2 3.3 2 1 0 2 2 2 1 Bromodomain extra-terminal - transcription regulation BACK PF07707.15 ELR21773.1 - 0.033 14.3 0.6 8.2 6.6 0.0 3.3 3 0 0 3 3 3 0 BTB And C-terminal Kelch MgtE_N PF03448.17 ELR21773.1 - 0.14 12.7 0.6 1.1 9.9 0.0 2.6 2 0 0 2 2 2 0 MgtE intracellular N domain SR-25 PF10500.9 ELR21773.1 - 0.41 10.2 32.5 0.092 12.3 10.4 2.6 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein CDC45 PF02724.14 ELR21773.1 - 5.7 5.1 7.5 13 3.9 7.5 1.5 1 0 0 1 1 1 0 CDC45-like protein RCC1 PF00415.18 ELR21774.1 - 2.2e-74 245.9 23.2 5.3e-17 62.2 0.1 6.0 5 1 1 6 6 6 6 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 ELR21774.1 - 2.1e-24 84.7 36.7 2.6e-06 27.1 2.5 6.3 6 0 0 6 6 6 5 Regulator of chromosome condensation (RCC1) repeat DUF4213 PF13938.6 ELR21774.1 - 0.011 15.9 0.2 0.36 11.1 0.0 2.7 2 1 1 3 3 3 0 Putative heavy-metal chelation Phage_holin_3_6 PF07332.11 ELR21775.1 - 0.0049 16.9 0.2 0.0056 16.7 0.2 1.1 1 0 0 1 1 1 1 Putative Actinobacterial Holin-X, holin superfamily III Fijivirus_P9-2 PF06837.11 ELR21775.1 - 0.2 11.1 0.1 0.25 10.8 0.1 1.1 1 0 0 1 1 1 0 Fijivirus P9-2 protein Na_H_Exchanger PF00999.21 ELR21776.1 - 5e-54 183.6 48.4 7.5e-54 183.0 48.4 1.2 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family Usp PF00582.26 ELR21776.1 - 0.002 18.6 3.4 1.1 9.7 0.0 3.6 4 0 0 4 4 4 2 Universal stress protein family Pkinase_Tyr PF07714.17 ELR21777.1 - 5.8e-60 202.7 0.0 7.8e-60 202.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ELR21777.1 - 1.5e-51 175.3 0.0 2.3e-51 174.7 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain SH2 PF00017.24 ELR21777.1 - 9.3e-08 32.1 0.0 2.3e-07 30.8 0.0 1.7 1 0 0 1 1 1 1 SH2 domain APH PF01636.23 ELR21777.1 - 0.0015 18.5 0.0 0.039 13.9 0.0 2.3 1 1 1 2 2 2 1 Phosphotransferase enzyme family RIO1 PF01163.22 ELR21777.1 - 0.015 14.9 0.1 0.03 13.9 0.1 1.5 1 0 0 1 1 1 0 RIO1 family Nmad2 PF18753.1 ELR21777.1 - 0.17 11.3 0.5 0.84 9.1 1.4 1.6 2 0 0 2 2 2 0 Nucleotide modification associated domain 2 ORC6 PF05460.13 ELR21778.1 - 1.1 8.4 4.4 1.6 7.9 4.4 1.1 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) MSA-2c PF12238.8 ELR21778.1 - 2.1 8.3 9.8 3.2 7.7 9.8 1.2 1 0 0 1 1 1 0 Merozoite surface antigen 2c SKG6 PF08693.10 ELR21779.1 - 8.1e-05 22.0 5.1 0.00022 20.6 5.1 1.8 1 0 0 1 1 1 1 Transmembrane alpha-helix domain DUF4448 PF14610.6 ELR21779.1 - 0.017 14.9 0.0 0.038 13.8 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF4448) DUF3808 PF10300.9 ELR21780.1 - 2.3e-27 95.9 9.0 1.2e-20 73.7 2.6 2.5 1 1 1 2 2 2 2 Protein of unknown function (DUF3808) TPR_12 PF13424.6 ELR21780.1 - 3e-06 27.4 11.3 0.096 13.0 0.1 5.2 4 1 1 5 5 5 3 Tetratricopeptide repeat TPR_7 PF13176.6 ELR21780.1 - 0.068 13.2 1.6 0.78 9.9 0.3 3.4 2 0 0 2 2 2 0 Tetratricopeptide repeat TbpB_A PF17484.2 ELR21780.1 - 0.071 13.9 0.0 0.17 12.6 0.0 1.6 1 0 0 1 1 1 0 N-Lobe handle Tf-binding protein B TPR_16 PF13432.6 ELR21780.1 - 0.3 11.8 4.7 19 6.0 1.1 3.5 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_2 PF07719.17 ELR21780.1 - 0.36 11.0 18.8 0.3 11.3 0.2 6.2 7 0 0 7 7 7 0 Tetratricopeptide repeat Spore_YpjB PF09577.10 ELR21780.1 - 0.47 10.2 4.5 6.7 6.4 0.6 2.6 2 0 0 2 2 2 0 Sporulation protein YpjB (SpoYpjB) TPR_14 PF13428.6 ELR21780.1 - 0.85 10.6 5.3 8.6 7.5 0.1 4.1 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_6 PF13174.6 ELR21780.1 - 1.6 9.5 18.4 27 5.7 0.1 6.8 7 2 0 7 7 7 0 Tetratricopeptide repeat zf-MYND PF01753.18 ELR21781.1 - 0.2 11.7 13.7 0.32 11.1 11.9 2.2 2 1 0 2 2 2 0 MYND finger LRR_8 PF13855.6 ELR21784.1 - 1.1e-22 79.6 10.5 3.8e-10 39.4 2.3 4.2 2 1 2 4 4 4 3 Leucine rich repeat LRR_4 PF12799.7 ELR21784.1 - 9.1e-21 73.6 15.6 2.2e-06 27.9 0.1 4.9 2 1 1 4 4 4 4 Leucine Rich repeats (2 copies) DSPc PF00782.20 ELR21784.1 - 4.6e-16 58.8 0.0 6.5e-16 58.4 0.0 1.2 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain LRR_1 PF00560.33 ELR21784.1 - 5.6e-10 38.4 11.2 2 9.2 0.1 7.4 7 0 0 7 7 7 4 Leucine Rich Repeat LRR_9 PF14580.6 ELR21784.1 - 1.5e-07 31.1 0.3 0.006 16.1 0.1 2.5 2 1 1 3 3 3 3 Leucine-rich repeat LRR_6 PF13516.6 ELR21784.1 - 1.5e-05 24.6 17.8 0.14 12.3 0.1 6.6 6 0 0 6 6 6 2 Leucine Rich repeat KGG PF10685.9 ELR21785.1 - 3.9e-42 141.3 28.0 1.8e-09 37.6 0.4 5.8 5 0 0 5 5 5 5 Stress-induced bacterial acidophilic repeat motif Se-cys_synth_N PF12390.8 ELR21785.1 - 0.7 10.2 5.2 20 5.5 0.1 3.6 4 0 0 4 4 4 0 Selenocysteine synthase N terminal CEP170_C PF15308.6 ELR21785.1 - 9.7 4.6 14.1 18 3.8 9.4 2.4 2 1 1 3 3 3 0 CEP170 C-terminus KGG PF10685.9 ELR21786.1 - 3.1e-58 192.5 40.9 8.9e-09 35.3 0.6 7.8 7 0 0 7 7 7 7 Stress-induced bacterial acidophilic repeat motif FbpC_C_terminal PF17845.1 ELR21786.1 - 0.052 13.7 5.5 58 3.9 0.0 4.7 6 0 0 6 6 6 0 FbpC C-terminal regulatory nucleotide binding domain Methyltransf_16 PF10294.9 ELR21787.1 - 1.5e-39 135.5 0.0 2.1e-39 135.0 0.0 1.1 1 0 0 1 1 1 1 Lysine methyltransferase Methyltransf_23 PF13489.6 ELR21787.1 - 0.00017 21.4 0.0 0.00029 20.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain TFIIE-A_C PF11521.8 ELR21787.1 - 0.2 11.9 1.4 0.46 10.8 1.4 1.6 1 0 0 1 1 1 0 C-terminal general transcription factor TFIIE alpha GidB PF02527.15 ELR21787.1 - 0.21 10.9 0.0 0.41 9.9 0.0 1.5 1 0 0 1 1 1 0 rRNA small subunit methyltransferase G LRR_6 PF13516.6 ELR21788.1 - 1.5e-05 24.6 17.5 2.5 8.4 0.3 8.4 9 0 0 9 9 9 2 Leucine Rich repeat LRR_1 PF00560.33 ELR21788.1 - 0.076 13.6 13.8 5.8 7.9 0.2 6.6 8 0 0 8 8 8 0 Leucine Rich Repeat LRR_4 PF12799.7 ELR21788.1 - 0.17 12.4 14.0 4.1 8.0 1.6 5.2 3 1 1 5 5 5 0 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 ELR21788.1 - 1.3 8.9 8.2 2.1 8.2 0.8 4.4 3 1 1 4 4 4 0 Leucine rich repeat PPR_2 PF13041.6 ELR21789.1 - 2.9e-61 203.5 9.1 2e-10 40.7 0.2 11.8 2 1 10 12 12 12 10 PPR repeat family PPR PF01535.20 ELR21789.1 - 8.2e-60 195.0 8.9 7.3e-05 22.8 0.0 12.0 12 0 0 12 12 12 10 PPR repeat PPR_3 PF13812.6 ELR21789.1 - 1.9e-55 184.8 0.0 2e-09 37.3 0.0 8.0 6 2 2 8 8 8 6 Pentatricopeptide repeat domain PPR_1 PF12854.7 ELR21789.1 - 7.3e-48 159.9 0.0 0.00011 21.8 0.0 11.4 12 0 0 12 12 12 8 PPR repeat PPR_long PF17177.4 ELR21789.1 - 3.3e-36 124.7 0.4 1.7e-11 43.9 0.0 4.5 1 1 4 5 5 5 5 Pentacotripeptide-repeat region of PRORP ECSIT PF06239.11 ELR21789.1 - 8.9e-07 28.3 0.2 1.5 7.9 0.0 5.5 3 2 3 6 6 6 2 Evolutionarily conserved signalling intermediate in Toll pathway ATP13 PF12921.7 ELR21789.1 - 1.4e-05 24.9 0.5 1.5 8.7 0.0 5.6 2 2 3 5 5 5 1 Mitochondrial ATPase expression TPR_14 PF13428.6 ELR21789.1 - 3.3e-05 24.3 6.4 8 7.6 0.1 7.0 6 2 2 8 8 6 1 Tetratricopeptide repeat TPR_15 PF13429.6 ELR21789.1 - 0.00026 20.3 0.3 0.94 8.6 0.0 3.0 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_4 PF07721.14 ELR21789.1 - 0.0066 17.0 0.2 3.2 8.7 0.1 4.2 3 0 0 3 3 3 1 Tetratricopeptide repeat Clathrin PF00637.20 ELR21789.1 - 0.01 15.7 0.1 1.1 9.2 0.0 3.5 3 1 0 3 3 3 0 Region in Clathrin and VPS MRP-S27 PF10037.9 ELR21789.1 - 0.021 13.7 0.0 0.83 8.5 0.0 3.0 2 1 2 4 4 4 0 Mitochondrial 28S ribosomal protein S27 SPOB_a PF14689.6 ELR21789.1 - 0.033 13.9 0.5 5.8 6.7 0.0 3.9 4 0 0 4 4 4 0 Sensor_kinase_SpoOB-type, alpha-helical domain TetR_C_8 PF14278.6 ELR21789.1 - 0.044 13.9 0.0 15 5.8 0.0 2.6 2 0 0 2 2 2 0 Transcriptional regulator C-terminal region SelB-wing_2 PF09106.11 ELR21789.1 - 0.06 13.6 0.1 7.9 6.8 0.0 4.2 4 0 0 4 4 4 0 Elongation factor SelB, winged helix TPR_2 PF07719.17 ELR21789.1 - 0.079 13.1 0.1 75 3.8 0.0 4.0 3 0 0 3 3 3 0 Tetratricopeptide repeat Pkinase_Tyr PF07714.17 ELR21790.1 - 2.8e-55 187.4 0.0 8.1e-55 185.9 0.0 1.8 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ELR21790.1 - 9.5e-50 169.4 0.0 9.5e-50 169.4 0.0 3.1 3 1 0 3 3 3 1 Protein kinase domain Kinase-like PF14531.6 ELR21790.1 - 6.8e-06 25.6 0.0 2e-05 24.1 0.0 1.8 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 ELR21790.1 - 3.3e-05 22.9 0.1 3.3e-05 22.9 0.1 3.5 2 1 0 3 3 3 1 Fungal protein kinase APH PF01636.23 ELR21790.1 - 0.0041 17.1 0.0 0.0041 17.1 0.0 3.1 2 1 0 2 2 2 1 Phosphotransferase enzyme family CK_II_beta PF01214.18 ELR21791.1 - 1e-82 276.4 0.0 1.2e-82 276.1 0.0 1.1 1 0 0 1 1 1 1 Casein kinase II regulatory subunit CxC5 PF18718.1 ELR21791.1 - 0.062 13.4 0.1 0.1 12.7 0.1 1.3 1 0 0 1 1 1 0 CxC5 like cysteine cluster associated with KDZ transposases adh_short PF00106.25 ELR21792.1 - 3.2e-33 114.8 0.0 5e-33 114.2 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ELR21792.1 - 3.2e-23 82.5 0.0 5.1e-23 81.8 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase DUF1776 PF08643.10 ELR21792.1 - 9.8e-05 21.9 0.0 0.00014 21.4 0.0 1.1 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) KR PF08659.10 ELR21792.1 - 0.00037 20.4 0.0 0.00053 19.9 0.0 1.2 1 0 0 1 1 1 1 KR domain F-box-like PF12937.7 ELR21793.1 - 9.8e-09 35.0 0.2 2.3e-08 33.8 0.2 1.7 1 0 0 1 1 1 1 F-box-like eIF-5a PF01287.20 ELR21793.1 - 2.7e-05 24.2 0.0 4.8e-05 23.4 0.0 1.4 1 0 0 1 1 1 1 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold F-box PF00646.33 ELR21793.1 - 0.001 18.9 0.1 0.0028 17.5 0.1 1.8 1 0 0 1 1 1 1 F-box domain Sulfate_transp PF00916.20 ELR21794.1 - 3.7e-71 239.9 23.2 2.1e-58 197.9 11.9 2.5 1 1 1 2 2 2 2 Sulfate permease family STAS PF01740.21 ELR21794.1 - 2.1e-24 85.4 0.1 6.3e-24 83.9 0.0 1.8 2 0 0 2 2 2 1 STAS domain STAS_2 PF13466.6 ELR21794.1 - 0.0056 17.0 0.0 0.018 15.3 0.0 1.9 1 0 0 1 1 1 1 STAS domain PcfK PF14058.6 ELR21794.1 - 0.069 13.4 4.4 0.16 12.3 4.4 1.5 1 0 0 1 1 1 0 PcfK-like protein Ribosomal_60s PF00428.19 ELR21794.1 - 0.52 10.9 5.9 2.4 8.8 5.9 2.1 1 0 0 1 1 1 0 60s Acidic ribosomal protein MFS_MOT1 PF16983.5 ELR21794.1 - 4.1 7.9 12.1 0.12 12.8 3.9 2.3 2 0 0 2 2 2 0 Molybdate transporter of MFS superfamily Pkinase_Tyr PF07714.17 ELR21795.1 - 1.5e-53 181.8 0.0 2.1e-53 181.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ELR21795.1 - 7e-48 163.3 0.0 9.8e-48 162.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain SH2 PF00017.24 ELR21795.1 - 3.4e-10 39.9 0.0 7e-10 38.9 0.0 1.5 1 0 0 1 1 1 1 SH2 domain APH PF01636.23 ELR21795.1 - 0.0011 18.9 5.1 0.0025 17.8 1.1 3.3 2 2 0 2 2 2 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 ELR21795.1 - 0.027 13.4 0.0 0.047 12.6 0.0 1.3 1 0 0 1 1 1 0 Haspin like kinase domain RIO1 PF01163.22 ELR21795.1 - 0.048 13.2 0.0 0.09 12.4 0.0 1.4 1 0 0 1 1 1 0 RIO1 family p450 PF00067.22 ELR21796.1 - 1.9e-43 148.9 0.0 2.3e-43 148.6 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 CTP_transf_like PF01467.26 ELR21798.1 - 1.4e-11 44.8 0.1 1e-09 38.7 0.1 2.1 1 1 0 1 1 1 1 Cytidylyltransferase-like Motile_Sperm PF00635.26 ELR21799.1 - 5.2e-14 52.0 0.2 7.6e-13 48.3 0.0 2.2 2 0 0 2 2 2 1 MSP (Major sperm protein) domain Pkinase_Tyr PF07714.17 ELR21800.1 - 6e-54 183.0 0.0 8.1e-54 182.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ELR21800.1 - 9.3e-52 176.0 0.0 1.3e-51 175.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain SH2 PF00017.24 ELR21800.1 - 3.8e-07 30.1 0.0 8e-07 29.1 0.0 1.5 1 0 0 1 1 1 1 SH2 domain APH PF01636.23 ELR21800.1 - 0.0012 18.8 2.9 0.0049 16.8 0.0 2.9 2 2 2 4 4 4 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 ELR21800.1 - 0.11 11.5 0.0 0.2 10.6 0.0 1.3 1 0 0 1 1 1 0 Haspin like kinase domain Pkinase_Tyr PF07714.17 ELR21801.1 - 1.4e-53 181.8 0.0 1.2e-46 159.1 0.0 2.2 1 1 1 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 ELR21801.1 - 4.1e-49 167.3 0.0 3.1e-42 144.8 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain SH2 PF00017.24 ELR21801.1 - 1.8e-06 27.9 1.4 4.1e-06 26.8 0.0 2.3 3 0 0 3 3 3 1 SH2 domain APH PF01636.23 ELR21801.1 - 0.0002 21.4 0.0 0.023 14.7 0.0 2.6 1 1 1 2 2 2 2 Phosphotransferase enzyme family Haspin_kinase PF12330.8 ELR21801.1 - 0.02 13.9 0.0 0.037 13.0 0.0 1.5 1 1 0 1 1 1 0 Haspin like kinase domain Sdh5 PF03937.16 ELR21802.1 - 9.4e-23 80.0 0.3 1.4e-22 79.4 0.3 1.3 1 0 0 1 1 1 1 Flavinator of succinate dehydrogenase Rap_GAP PF02145.15 ELR21803.1 - 1.3e-58 197.6 0.0 2e-58 197.0 0.0 1.3 1 0 0 1 1 1 1 Rap/ran-GAP Pkinase_Tyr PF07714.17 ELR21804.1 - 1.6e-57 194.8 0.0 2.5e-57 194.1 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ELR21804.1 - 1.8e-46 158.7 0.0 3.4e-46 157.7 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain SH2 PF00017.24 ELR21804.1 - 2.5e-14 53.1 0.0 6.3e-14 51.8 0.0 1.7 1 0 0 1 1 1 1 SH2 domain Cbl_N2 PF02761.14 ELR21804.1 - 0.11 13.2 0.0 0.27 12.0 0.0 1.6 1 0 0 1 1 1 0 CBL proto-oncogene N-terminus, EF hand-like domain APH PF01636.23 ELR21804.1 - 0.18 11.7 0.1 0.37 10.7 0.1 1.5 1 0 0 1 1 1 0 Phosphotransferase enzyme family MAP65_ASE1 PF03999.12 ELR21805.1 - 8.2e-65 219.6 12.1 1.4e-64 218.8 12.1 1.3 1 1 0 1 1 1 1 Microtubule associated protein (MAP65/ASE1 family) BST2 PF16716.5 ELR21805.1 - 0.13 12.9 6.3 2.6 8.7 0.1 3.2 3 0 0 3 3 3 0 Bone marrow stromal antigen 2 F-box-like PF12937.7 ELR21806.1 - 5.2e-11 42.3 1.3 1.4e-10 40.8 1.3 1.8 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ELR21806.1 - 1.6e-08 34.2 0.5 3.5e-08 33.1 0.5 1.6 1 0 0 1 1 1 1 F-box domain F-box_4 PF15966.5 ELR21806.1 - 0.0006 19.7 0.3 0.0018 18.1 0.3 1.9 1 1 0 1 1 1 1 F-box WD40 PF00400.32 ELR21806.1 - 0.003 18.3 0.1 0.003 18.3 0.1 2.8 3 1 0 3 3 3 1 WD domain, G-beta repeat RCC1 PF00415.18 ELR21807.1 - 2.6e-14 53.6 14.4 9.6e-07 29.3 0.7 6.7 6 1 0 6 6 6 3 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 ELR21807.1 - 2.4e-10 39.9 26.4 4.8e-06 26.2 0.8 6.3 7 0 0 7 7 7 3 Regulator of chromosome condensation (RCC1) repeat SKG6 PF08693.10 ELR21807.1 - 0.93 9.0 8.4 3.9 7.0 8.4 2.2 1 0 0 1 1 1 0 Transmembrane alpha-helix domain NAGLU PF05089.12 ELR21808.1 - 6.5e-127 423.1 9.3 2e-126 421.5 9.3 1.8 1 1 0 1 1 1 1 Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain NAGLU_C PF12972.7 ELR21808.1 - 6.3e-76 255.4 3.9 9.2e-76 254.9 3.9 1.3 1 0 0 1 1 1 1 Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain NAGLU_N PF12971.7 ELR21808.1 - 8.3e-14 51.1 0.2 2.7e-13 49.5 0.0 2.0 2 0 0 2 2 2 1 Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain DUF1648 PF07853.11 ELR21808.1 - 0.33 10.6 1.9 0.47 10.2 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1648) Rax2 PF12768.7 ELR21809.1 - 0.085 12.3 0.2 0.14 11.5 0.2 1.3 1 0 0 1 1 1 0 Cortical protein marker for cell polarity SKG6 PF08693.10 ELR21809.1 - 0.21 11.1 13.0 0.56 9.7 13.0 1.7 1 0 0 1 1 1 0 Transmembrane alpha-helix domain DUF4448 PF14610.6 ELR21809.1 - 0.3 10.8 1.0 0.9 9.3 0.9 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF4448) AI-2E_transport PF01594.16 ELR21810.1 - 5.6e-10 38.9 23.1 5.6e-10 38.9 23.1 5.0 6 1 1 7 7 7 2 AI-2E family transporter ERF PF04404.12 ELR21810.1 - 5.5 6.8 6.4 15 5.4 6.4 1.7 1 0 0 1 1 1 0 ERF superfamily RCC1 PF00415.18 ELR21811.1 - 8.8e-18 64.7 4.3 1.4e-08 35.3 0.8 2.1 2 0 0 2 2 2 2 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 ELR21811.1 - 6.9e-09 35.3 18.3 0.0012 18.5 1.3 3.8 3 1 0 3 3 3 3 Regulator of chromosome condensation (RCC1) repeat DUF11 PF01345.18 ELR21813.1 - 0.11 12.8 0.0 0.16 12.3 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function DUF11 RCC1 PF00415.18 ELR21814.1 - 2.6e-21 76.0 10.8 4.9e-09 36.7 0.8 6.4 5 1 1 6 6 6 4 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 ELR21814.1 - 1.3e-18 66.3 28.6 8.4e-07 28.6 2.8 6.1 6 0 0 6 6 6 3 Regulator of chromosome condensation (RCC1) repeat Vpu PF00558.19 ELR21814.1 - 0.0045 16.7 0.6 0.0081 15.9 0.6 1.3 1 0 0 1 1 1 1 Vpu protein Acetyltransf_1 PF00583.25 ELR21815.1 - 1e-10 41.8 0.1 1.4e-08 35.0 0.0 2.3 2 0 0 2 2 2 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 ELR21815.1 - 2.4e-07 30.7 0.0 5e-07 29.7 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 ELR21815.1 - 7.3e-06 26.3 0.0 1.6e-05 25.3 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 ELR21815.1 - 2.9e-05 24.0 0.0 5.7e-05 23.0 0.0 1.5 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_9 PF13527.7 ELR21815.1 - 0.00086 19.4 0.0 2 8.5 0.0 2.7 2 1 0 2 2 2 2 Acetyltransferase (GNAT) domain Acetyltransf_6 PF13480.7 ELR21815.1 - 0.0013 18.9 0.1 0.0032 17.6 0.0 1.7 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.7 ELR21815.1 - 0.022 15.5 0.0 2.6 8.7 0.0 2.2 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain Acetyltransf_18 PF18014.1 ELR21815.1 - 0.034 14.0 0.0 10 6.0 0.0 2.4 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain PanZ PF12568.8 ELR21815.1 - 0.17 11.6 0.0 18 5.1 0.0 2.5 2 1 0 2 2 2 0 Acetyltransferase (GNAT) domain, PanZ Acetyltransf_1 PF00583.25 ELR21816.1 - 1.8e-08 34.6 0.0 3.4e-08 33.7 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 ELR21816.1 - 3.9e-06 26.8 0.0 6.5e-06 26.1 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 ELR21816.1 - 3.4e-05 24.2 0.0 6.1e-05 23.4 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 ELR21816.1 - 0.00047 20.1 0.0 0.00077 19.4 0.0 1.4 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_3 PF13302.7 ELR21816.1 - 0.0042 17.8 0.0 0.28 11.8 0.0 2.2 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 ELR21816.1 - 0.03 14.4 0.0 3.2 7.8 0.0 2.5 2 1 0 2 2 2 0 Acetyltransferase (GNAT) domain PP2C PF00481.21 ELR21817.1 - 0.0068 16.1 1.2 0.0096 15.6 1.2 1.5 1 1 0 1 1 1 1 Protein phosphatase 2C Ribosomal_L30 PF00327.20 ELR21818.1 - 0.12 12.2 0.0 0.3 11.0 0.0 1.6 1 0 0 1 1 1 0 Ribosomal protein L30p/L7e G-alpha PF00503.20 ELR21820.1 - 0.0029 16.8 0.0 0.0034 16.6 0.0 1.0 1 0 0 1 1 1 1 G-protein alpha subunit AAA_24 PF13479.6 ELR21820.1 - 0.062 13.0 0.0 0.082 12.6 0.0 1.2 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.6 ELR21820.1 - 0.093 12.3 0.5 0.39 10.3 0.5 2.0 1 1 0 1 1 1 0 AAA domain Arf PF00025.21 ELR21820.1 - 0.18 11.2 0.0 0.21 11.0 0.0 1.1 1 0 0 1 1 1 0 ADP-ribosylation factor family PPP5 PF08321.12 ELR21821.1 - 0.097 13.0 0.0 0.15 12.4 0.0 1.3 1 0 0 1 1 1 0 PPP5 TPR repeat region Beta_protein PF14350.6 ELR21821.1 - 0.12 11.8 0.0 0.15 11.4 0.0 1.1 1 0 0 1 1 1 0 Beta protein Response_reg PF00072.24 ELR21822.1 - 8.9e-15 54.8 0.0 1.1e-14 54.5 0.0 1.1 1 0 0 1 1 1 1 Response regulator receiver domain ABC2_membrane_3 PF12698.7 ELR21822.1 - 6.5 5.8 11.8 8.5 5.4 11.8 1.1 1 0 0 1 1 1 0 ABC-2 family transporter protein Thioredoxin PF00085.20 ELR21824.1 - 8.6e-07 28.9 0.2 3e-06 27.2 0.2 2.0 1 1 0 1 1 1 1 Thioredoxin DUF1467 PF07330.12 ELR21824.1 - 0.029 14.3 0.1 0.049 13.6 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1467) ECSCR PF15820.5 ELR21824.1 - 0.047 13.5 0.0 0.064 13.1 0.0 1.2 1 0 0 1 1 1 0 Endothelial cell-specific chemotaxis regulator Thioredoxin_2 PF13098.6 ELR21824.1 - 0.051 14.0 0.4 0.28 11.6 0.1 2.1 2 1 1 3 3 3 0 Thioredoxin-like domain AhpC-TSA PF00578.21 ELR21824.1 - 0.072 13.0 0.0 0.11 12.4 0.0 1.3 1 0 0 1 1 1 0 AhpC/TSA family PepSY_2 PF13670.6 ELR21824.1 - 0.1 12.6 0.1 0.18 11.8 0.1 1.5 1 1 0 1 1 1 0 Peptidase propeptide and YPEB domain Response_reg PF00072.24 ELR21826.1 - 1.4e-27 96.1 0.1 3.2e-27 94.9 0.1 1.7 1 0 0 1 1 1 1 Response regulator receiver domain HATPase_c PF02518.26 ELR21826.1 - 2.8e-23 82.6 0.2 2.6e-22 79.4 0.2 2.3 1 1 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 ELR21826.1 - 2.7e-13 49.7 2.2 4.9e-13 48.9 0.8 2.3 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain GAF_3 PF13492.6 ELR21826.1 - 0.00017 21.9 0.0 0.001 19.4 0.0 2.4 2 0 0 2 2 2 1 GAF domain PAS_4 PF08448.10 ELR21826.1 - 0.0016 18.7 0.1 0.0049 17.1 0.1 1.8 1 0 0 1 1 1 1 PAS fold GAF_2 PF13185.6 ELR21826.1 - 0.0019 18.5 0.0 0.041 14.2 0.0 2.7 3 0 0 3 3 3 1 GAF domain TetR_C_18 PF17923.1 ELR21826.1 - 0.092 13.3 0.4 0.28 11.7 0.4 1.8 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain HATPase_c PF02518.26 ELR21827.1 - 2.4e-19 69.9 0.1 4.9e-19 68.9 0.1 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 ELR21827.1 - 4.4e-11 42.7 1.4 4.1e-10 39.5 1.4 2.6 1 1 0 1 1 1 1 His Kinase A (phospho-acceptor) domain GAF_2 PF13185.6 ELR21827.1 - 0.00031 21.1 0.0 0.16 12.2 0.0 2.6 2 1 0 2 2 2 2 GAF domain HATPase_c_3 PF13589.6 ELR21827.1 - 0.0033 17.2 0.0 0.0075 16.1 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase PAS_4 PF08448.10 ELR21827.1 - 0.025 14.8 0.0 0.1 12.9 0.0 2.0 1 0 0 1 1 1 0 PAS fold Totivirus_coat PF05518.11 ELR21827.1 - 0.29 9.1 2.8 0.49 8.4 2.8 1.2 1 0 0 1 1 1 0 Totivirus coat protein PRR20 PF15708.5 ELR21827.1 - 0.33 10.8 4.8 0.58 10.0 4.8 1.3 1 0 0 1 1 1 0 Proline-rich protein family 20 WH2 PF02205.20 ELR21828.1 - 2.8e-09 36.5 0.5 8.1e-09 35.0 0.5 1.9 1 0 0 1 1 1 1 WH2 motif Tropomyosin PF00261.20 ELR21828.1 - 0.00024 20.5 34.6 2.9 7.2 34.6 3.6 1 1 0 1 1 1 1 Tropomyosin DZR PF12773.7 ELR21828.1 - 0.0016 18.4 1.1 0.0027 17.7 1.1 1.4 1 0 0 1 1 1 1 Double zinc ribbon zf-ribbon_3 PF13248.6 ELR21828.1 - 0.027 13.9 2.6 0.047 13.1 2.6 1.4 1 0 0 1 1 1 0 zinc-ribbon domain zinc_ribbon_2 PF13240.6 ELR21828.1 - 0.11 12.3 4.7 0.19 11.5 4.7 1.4 1 0 0 1 1 1 0 zinc-ribbon domain Thymosin PF01290.20 ELR21828.1 - 0.12 12.1 0.0 0.26 11.0 0.0 1.5 1 0 0 1 1 1 0 Thymosin beta-4 family XhlA PF10779.9 ELR21828.1 - 0.22 11.7 14.3 4.2 7.6 0.6 3.9 4 0 0 4 4 4 0 Haemolysin XhlA CHDCT2 PF08074.11 ELR21828.1 - 0.31 11.2 0.0 0.31 11.2 0.0 2.4 2 1 0 2 2 2 0 CHDCT2 (NUC038) domain Tli4_N PF18443.1 ELR21828.1 - 0.34 11.3 1.9 6.9 7.0 1.7 2.5 2 1 0 2 2 2 0 Tle cognate immunity protein 4 N-terminal domain Sugarporin_N PF11471.8 ELR21828.1 - 0.49 10.4 48.7 0.39 10.7 14.3 4.5 3 1 0 4 4 4 0 Maltoporin periplasmic N-terminal extension PRKG1_interact PF15898.5 ELR21828.1 - 2.4 9.1 23.0 0.13 13.2 3.8 2.8 1 1 2 3 3 3 0 cGMP-dependent protein kinase interacting domain V_ATPase_I PF01496.19 ELR21828.1 - 2.9 5.7 8.7 3.8 5.3 8.7 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family PAS_4 PF08448.10 ELR21829.1 - 9.1e-07 29.1 0.1 2.7e-05 24.4 0.0 2.4 2 0 0 2 2 2 1 PAS fold Response_reg PF00072.24 ELR21830.1 - 8.4e-47 158.0 0.5 7.3e-26 90.5 0.1 2.4 2 0 0 2 2 2 2 Response regulator receiver domain HATPase_c PF02518.26 ELR21830.1 - 2.9e-43 146.9 0.0 4.6e-21 75.4 0.2 3.1 2 1 0 2 2 2 2 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 ELR21830.1 - 1.2e-27 95.7 11.3 3.9e-14 52.4 0.2 3.7 3 0 0 3 3 3 2 His Kinase A (phospho-acceptor) domain PAS_4 PF08448.10 ELR21830.1 - 8e-12 45.4 0.1 4.4e-11 43.0 0.0 2.3 2 0 0 2 2 2 1 PAS fold GAF_3 PF13492.6 ELR21830.1 - 8.1e-07 29.4 0.1 5.3e-05 23.6 0.0 3.0 3 0 0 3 3 3 1 GAF domain PAS PF00989.25 ELR21830.1 - 1.1e-05 25.4 0.0 2.8e-05 24.1 0.0 1.7 1 0 0 1 1 1 1 PAS fold GAF_2 PF13185.6 ELR21830.1 - 5.3e-05 23.5 0.1 0.0051 17.1 0.1 2.7 2 0 0 2 2 2 1 GAF domain PAS_8 PF13188.7 ELR21830.1 - 0.0013 18.7 0.1 0.003 17.5 0.1 1.6 1 0 0 1 1 1 1 PAS domain PAS_9 PF13426.7 ELR21830.1 - 0.0057 16.9 0.0 0.012 15.8 0.0 1.5 1 0 0 1 1 1 1 PAS domain SNF2_N PF00176.23 ELR21831.1 - 1.2e-15 57.2 0.1 1.8e-15 56.6 0.1 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 ELR21831.1 - 1.2e-08 35.3 0.0 2.9e-08 34.0 0.0 1.6 1 1 0 1 1 1 1 Helicase conserved C-terminal domain zf-C3HC4_3 PF13920.6 ELR21831.1 - 1.4e-08 34.5 10.4 2.9e-08 33.5 10.4 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 ELR21831.1 - 0.0014 18.4 9.7 0.0029 17.5 9.7 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4 PF00097.25 ELR21831.1 - 0.0015 18.3 13.3 0.0035 17.2 13.3 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 ELR21831.1 - 0.0075 16.6 12.8 0.022 15.1 12.8 1.9 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 ELR21831.1 - 0.021 14.6 12.8 0.069 13.0 12.8 2.0 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ELR21831.1 - 0.4 10.7 12.1 1.8 8.6 11.9 2.2 1 1 1 2 2 2 0 zinc-RING finger domain zf-RING_4 PF14570.6 ELR21831.1 - 0.82 9.5 12.4 1.9 8.3 12.4 1.7 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-RING_UBOX PF13445.6 ELR21831.1 - 2.8 8.0 8.8 6.5 6.9 8.8 1.7 1 0 0 1 1 1 0 RING-type zinc-finger DUF1700 PF08006.11 ELR21832.1 - 0.046 13.3 0.3 0.046 13.3 0.3 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1700) PIG-F PF06699.11 ELR21832.1 - 0.2 11.8 2.5 0.28 11.3 2.5 1.1 1 0 0 1 1 1 0 GPI biosynthesis protein family Pig-F FixQ PF05545.11 ELR21832.1 - 0.75 9.8 0.0 0.75 9.8 0.0 2.2 2 0 0 2 2 2 0 Cbb3-type cytochrome oxidase component FixQ PRA1 PF03208.19 ELR21832.1 - 0.79 9.3 4.2 1.1 8.9 4.2 1.2 1 0 0 1 1 1 0 PRA1 family protein TMEM51 PF15345.6 ELR21832.1 - 4.3 7.1 4.6 19 5.0 0.3 2.1 1 1 1 2 2 2 0 Transmembrane protein 51 GTP_EFTU_D3 PF03143.17 ELR21834.1 - 0.00024 21.4 0.0 0.00038 20.7 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain DUF2909 PF11137.8 ELR21834.1 - 0.39 10.7 2.5 0.46 10.5 0.3 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2909) Phage-MuB_C PF09077.11 ELR21836.1 - 0.0059 16.5 0.1 0.02 14.8 0.0 1.9 1 1 1 2 2 2 1 Mu B transposition protein, C terminal DUF3040 PF11239.8 ELR21836.1 - 0.043 14.1 0.1 0.084 13.2 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3040) TraO PF10626.9 ELR21840.1 - 0.091 12.5 0.1 0.11 12.3 0.1 1.1 1 0 0 1 1 1 0 Conjugative transposon protein TraO SR-25 PF10500.9 ELR21841.1 - 0.067 12.8 21.6 0.08 12.5 21.6 1.0 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein FAM220 PF15487.6 ELR21841.1 - 0.068 12.8 8.2 0.077 12.6 8.2 1.0 1 0 0 1 1 1 0 FAM220 family Sin_N PF04801.13 ELR21841.1 - 1.1 8.4 12.0 1.2 8.3 12.0 1.0 1 0 0 1 1 1 0 Sin-like protein conserved region Apt1 PF10351.9 ELR21841.1 - 2.5 6.9 16.4 2.5 6.8 16.4 1.0 1 0 0 1 1 1 0 Golgi-body localisation protein domain Rtf2 PF04641.12 ELR21841.1 - 4.4 6.6 15.9 5.9 6.2 15.9 1.3 1 0 0 1 1 1 0 Rtf2 RING-finger TFIIF_alpha PF05793.12 ELR21841.1 - 5.4 5.5 28.0 6.4 5.2 28.0 1.0 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) ALMT PF11744.8 ELR21841.1 - 5.4 5.7 12.8 6.3 5.5 12.8 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter CDC45 PF02724.14 ELR21841.1 - 7 4.8 18.1 7.9 4.6 18.1 1.0 1 0 0 1 1 1 0 CDC45-like protein dUTPase PF00692.19 ELR21842.1 - 2.1e-15 56.6 0.1 6.1e-11 42.1 0.1 2.0 1 1 1 2 2 2 2 dUTPase Thioredoxin PF00085.20 ELR21844.1 - 0.00028 20.8 0.5 0.00044 20.2 0.5 1.4 1 0 0 1 1 1 1 Thioredoxin PepSY_2 PF13670.6 ELR21844.1 - 0.0017 18.3 0.0 0.002 18.1 0.0 1.1 1 0 0 1 1 1 1 Peptidase propeptide and YPEB domain ECSCR PF15820.5 ELR21844.1 - 0.019 14.8 0.0 0.023 14.5 0.0 1.1 1 0 0 1 1 1 0 Endothelial cell-specific chemotaxis regulator Redoxin PF08534.10 ELR21844.1 - 0.12 12.1 0.0 0.16 11.6 0.0 1.3 1 0 0 1 1 1 0 Redoxin SP_C-Propep PF08999.10 ELR21844.1 - 0.12 12.2 1.3 0.19 11.5 1.3 1.3 1 0 0 1 1 1 0 Surfactant protein C, N terminal propeptide AhpC-TSA PF00578.21 ELR21844.1 - 0.14 12.1 0.0 0.2 11.6 0.0 1.2 1 0 0 1 1 1 0 AhpC/TSA family Helicase_PWI PF18149.1 ELR21848.1 - 0.0097 16.1 0.0 0.011 16.0 0.0 1.0 1 0 0 1 1 1 1 N-terminal helicase PWI domain DUF4886 PF16227.5 ELR21848.1 - 0.016 14.4 0.1 0.017 14.3 0.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4886) Fels1 PF05666.11 ELR21851.1 - 0.059 13.0 0.8 0.081 12.6 0.1 1.6 2 0 0 2 2 2 0 Fels-1 Prophage Protein-like Pkinase PF00069.25 ELR21852.1 - 4.5e-21 75.4 0.0 1e-19 71.0 0.0 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR21852.1 - 6.8e-09 35.4 0.0 6.4e-08 32.2 0.0 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 ELR21852.1 - 0.0011 18.9 0.4 0.77 9.6 0.1 2.8 2 1 1 3 3 3 2 Phosphotransferase enzyme family GCP5-Mod21 PF14609.6 ELR21854.1 - 0.0088 14.4 0.7 0.01 14.2 0.7 1.1 1 0 0 1 1 1 1 gamma-Tubulin ring complex non-core subunit mod21 DUF1389 PF07146.11 ELR21854.1 - 0.038 13.3 0.8 0.044 13.0 0.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1389) GIT_CC PF16559.5 ELR21854.1 - 0.039 13.8 0.9 0.08 12.8 0.9 1.5 1 0 0 1 1 1 0 GIT coiled-coil Rho guanine nucleotide exchange factor Eapp_C PF10238.9 ELR21854.1 - 0.079 13.0 2.4 8.3 6.5 1.5 2.1 2 0 0 2 2 2 0 E2F-associated phosphoprotein Ribosomal_L19e PF01280.20 ELR21854.1 - 0.12 12.5 8.4 0.88 9.6 4.0 2.1 1 1 1 2 2 2 0 Ribosomal protein L19e DUF2721 PF11026.8 ELR21854.1 - 0.13 12.1 0.1 0.26 11.2 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2721) Cas_CT1975 PF09344.10 ELR21854.1 - 0.77 9.2 5.3 0.91 8.9 5.3 1.0 1 0 0 1 1 1 0 CT1975-like protein SOR PF07682.11 ELR21855.1 - 0.12 11.3 1.3 0.12 11.3 1.3 1.2 1 0 0 1 1 1 0 Sulphur oxygenase reductase Glutaminase PF04960.15 ELR21858.1 - 1.1e-32 113.4 0.2 1.3e-32 113.1 0.2 1.1 1 0 0 1 1 1 1 Glutaminase CN_hydrolase PF00795.22 ELR21860.1 - 7.2e-41 140.2 0.0 1e-40 139.8 0.0 1.1 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase HA PF03457.14 ELR21862.1 - 3.3e-22 78.6 4.3 1.1e-17 64.1 0.2 2.2 2 0 0 2 2 2 2 Helicase associated domain Fe-S_assembly PF04384.13 ELR21862.1 - 0.038 14.6 0.1 0.39 11.3 0.1 2.1 2 0 0 2 2 2 0 Iron-sulphur cluster assembly zf-C3Hc3H PF13891.6 ELR21863.1 - 0.00041 20.7 11.6 0.0042 17.4 10.1 2.5 1 1 1 2 2 2 2 Potential DNA-binding domain RNA_pol_A_bac PF01000.26 ELR21864.1 - 7.4e-31 106.8 0.0 1.5e-30 105.8 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb3/RpoA insert domain RNA_pol_L PF01193.24 ELR21864.1 - 2.8e-21 74.7 0.0 4.6e-21 74.0 0.0 1.4 1 1 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain Fer4_9 PF13187.6 ELR21864.1 - 0.013 15.7 1.9 0.03 14.5 1.9 1.6 1 0 0 1 1 1 0 4Fe-4S dicluster domain RETICULATA-like PF11891.8 ELR21864.1 - 0.015 15.1 0.0 0.028 14.3 0.0 1.3 1 0 0 1 1 1 0 Protein RETICULATA-related Fer4_7 PF12838.7 ELR21864.1 - 0.16 12.6 2.1 0.35 11.5 2.1 1.6 1 0 0 1 1 1 0 4Fe-4S dicluster domain Ribonuc_L-PSP PF01042.21 ELR21865.1 - 6e-36 123.1 0.0 7.8e-36 122.7 0.0 1.1 1 0 0 1 1 1 1 Endoribonuclease L-PSP Rab3-GTPase_cat PF13890.6 ELR21865.1 - 0.0078 15.9 0.0 0.013 15.2 0.0 1.2 1 0 0 1 1 1 1 Rab3 GTPase-activating protein catalytic subunit zf-NF-X1 PF01422.17 ELR21866.1 - 1.6e-09 37.6 84.8 3.1e-06 27.1 13.8 16.8 18 1 0 18 18 18 9 NF-X1 type zinc finger Pyr_redox_2 PF07992.14 ELR21867.1 - 6.5e-38 130.6 0.0 2.2e-22 79.7 0.0 2.1 1 1 1 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 ELR21867.1 - 1.7e-11 44.5 0.0 1.2e-07 32.1 0.0 2.8 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase EF-hand_5 PF13202.6 ELR21867.1 - 0.0001 21.6 0.4 0.0002 20.7 0.4 1.5 1 0 0 1 1 1 1 EF hand EF-hand_1 PF00036.32 ELR21867.1 - 0.00061 19.2 0.4 0.0013 18.1 0.4 1.6 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.6 ELR21867.1 - 0.0013 18.5 0.3 0.0033 17.2 0.3 1.7 1 0 0 1 1 1 1 EF-hand domain EF-hand_7 PF13499.6 ELR21867.1 - 0.022 15.2 0.1 0.062 13.8 0.1 1.7 1 0 0 1 1 1 0 EF-hand domain pair HhH-GPD PF00730.25 ELR21868.1 - 6.4e-13 49.1 0.0 7.8e-13 48.8 0.0 1.2 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein HHH PF00633.23 ELR21868.1 - 1.1e-07 31.3 0.1 2.7e-07 30.1 0.0 1.7 2 0 0 2 2 2 1 Helix-hairpin-helix motif 3HCDH_RFF PF18321.1 ELR21868.1 - 0.0033 17.8 0.0 0.005 17.3 0.0 1.3 1 0 0 1 1 1 1 3-hydroxybutyryl-CoA dehydrogenase reduced Rossmann-fold domain UIM PF02809.20 ELR21869.1 - 0.0054 16.6 3.0 0.0054 16.6 3.0 2.5 2 0 0 2 2 2 1 Ubiquitin interaction motif UvrA_DNA-bind PF17755.1 ELR21869.1 - 0.027 14.8 0.0 0.056 13.8 0.0 1.6 1 0 0 1 1 1 0 UvrA DNA-binding domain Lactamase_B_6 PF16661.5 ELR21870.1 - 3.1e-06 26.8 0.0 6.3e-06 25.7 0.0 1.5 2 0 0 2 2 2 1 Metallo-beta-lactamase superfamily domain Beta_lactamase3 PF17030.5 ELR21870.1 - 0.0086 15.3 0.0 0.015 14.6 0.0 1.3 1 0 0 1 1 1 1 Putative beta-lactamase-like family Dynactin_p62 PF05502.13 ELR21871.1 - 4.1 6.1 7.6 0.56 8.9 2.1 2.0 2 0 0 2 2 2 0 Dynactin p62 family LRR_6 PF13516.6 ELR21872.1 - 1.4e-18 65.3 33.9 0.027 14.5 0.1 11.5 13 0 0 13 13 13 6 Leucine Rich repeat LRR_4 PF12799.7 ELR21872.1 - 3.8e-05 24.0 7.0 0.076 13.5 0.0 5.8 5 1 1 6 6 6 1 Leucine Rich repeats (2 copies) SpoU_sub_bind PF08032.12 ELR21872.1 - 0.00017 21.8 2.3 14 6.0 0.0 5.5 5 1 1 6 6 6 1 RNA 2'-O ribose methyltransferase substrate binding LRR_1 PF00560.33 ELR21872.1 - 0.00084 19.6 0.0 89 4.3 0.0 5.5 5 0 0 5 5 5 0 Leucine Rich Repeat G_glu_transpept PF01019.21 ELR21872.1 - 0.058 12.2 0.1 0.12 11.1 0.1 1.5 2 0 0 2 2 2 0 Gamma-glutamyltranspeptidase ATG27 PF09451.10 ELR21873.1 - 1.6e-08 34.7 0.0 1.9e-08 34.5 0.0 1.1 1 0 0 1 1 1 1 Autophagy-related protein 27 CIMR PF00878.18 ELR21873.1 - 8.8e-06 25.8 0.1 0.14 12.2 0.0 2.3 2 0 0 2 2 2 2 Cation-independent mannose-6-phosphate receptor repeat CIMR PF00878.18 ELR21874.1 - 2e-05 24.7 0.6 0.026 14.6 0.2 2.3 1 1 1 2 2 2 2 Cation-independent mannose-6-phosphate receptor repeat ATG27 PF09451.10 ELR21874.1 - 6.3e-05 23.0 0.1 7.4e-05 22.7 0.1 1.2 1 0 0 1 1 1 1 Autophagy-related protein 27 SNF2_N PF00176.23 ELR21875.1 - 1.6e-84 283.6 0.0 2.1e-84 283.2 0.0 1.1 1 0 0 1 1 1 1 SNF2 family N-terminal domain AP3D1 PF06375.11 ELR21875.1 - 2.3 8.5 21.1 4.9 7.4 12.5 2.2 2 0 0 2 2 2 0 AP-3 complex subunit delta-1 Nucleo_P87 PF07267.11 ELR21875.1 - 2.8 6.7 10.4 4.7 5.9 10.4 1.3 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 CDC45 PF02724.14 ELR21875.1 - 4 5.6 8.2 7.3 4.8 8.2 1.4 1 0 0 1 1 1 0 CDC45-like protein FancD2 PF14631.6 ELR21875.1 - 5.9 4.1 6.4 8.8 3.6 6.4 1.2 1 0 0 1 1 1 0 Fanconi anaemia protein FancD2 nuclease Nop14 PF04147.12 ELR21875.1 - 7 4.7 15.5 9.5 4.3 15.5 1.1 1 0 0 1 1 1 0 Nop14-like family FAM176 PF14851.6 ELR21875.1 - 7.2 6.3 13.6 0.97 9.1 6.7 2.2 2 0 0 2 2 2 0 FAM176 family 2OG-FeII_Oxy_3 PF13640.6 ELR21876.1 - 4.2e-08 34.0 0.0 6.4e-08 33.4 0.0 1.2 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily CDC27 PF09507.10 ELR21877.1 - 0.054 12.9 29.3 0.066 12.6 29.3 1.0 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Nucleo_P87 PF07267.11 ELR21877.1 - 0.072 11.9 18.5 0.087 11.7 18.5 1.0 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 AP3D1 PF06375.11 ELR21877.1 - 0.4 10.9 21.4 0.64 10.2 21.4 1.4 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 PPP4R2 PF09184.11 ELR21877.1 - 0.54 9.8 16.5 0.71 9.4 16.5 1.2 1 0 0 1 1 1 0 PPP4R2 CDC45 PF02724.14 ELR21877.1 - 5.4 5.2 24.6 6.9 4.8 24.6 1.2 1 0 0 1 1 1 0 CDC45-like protein U79_P34 PF03064.16 ELR21877.1 - 6.8 6.0 21.8 9.6 5.5 21.8 1.3 1 0 0 1 1 1 0 HSV U79 / HCMV P34 Serpin PF00079.20 ELR21879.1 - 1.7e-54 185.5 0.0 1e-53 183.0 0.0 1.8 1 1 0 1 1 1 1 Serpin (serine protease inhibitor) RT_RNaseH PF17917.1 ELR21882.1 - 2.1e-10 40.8 1.1 3.5e-10 40.1 0.8 1.5 1 1 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 ELR21882.1 - 1e-07 31.7 0.1 2.2e-07 30.6 0.1 1.7 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 ELR21882.1 - 0.00079 19.4 2.2 0.12 12.5 0.1 2.4 2 0 0 2 2 2 2 RNase H-like domain found in reverse transcriptase Gln_amidase PF15644.6 ELR21882.1 - 0.029 15.4 0.3 0.04 14.9 0.3 1.2 1 0 0 1 1 1 0 Papain fold toxin 1, glutamine deamidase DUF2371 PF10177.9 ELR21884.1 - 0.16 12.2 0.0 0.18 12.0 0.0 1.1 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2371) DOMON PF03351.17 ELR21885.1 - 6.4e-32 110.4 4.2 9.4e-12 45.2 0.1 4.3 2 2 1 3 3 3 3 DOMON domain Cytochrom_B561 PF03188.16 ELR21885.1 - 7e-06 26.2 11.0 7e-06 26.2 11.0 2.7 3 1 1 4 4 4 2 Eukaryotic cytochrome b561 RasGEF PF00617.19 ELR21886.1 - 8.3e-56 189.0 1.1 1.4e-55 188.2 1.1 1.4 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 ELR21886.1 - 1e-11 45.0 0.2 2.6e-10 40.5 0.0 3.0 2 1 0 2 2 2 1 RasGEF N-terminal motif DEP PF00610.21 ELR21886.1 - 2.8e-05 24.1 0.4 0.00011 22.2 0.0 2.2 2 0 0 2 2 2 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) CENP-H PF05837.12 ELR21886.1 - 0.0013 19.1 4.1 0.0033 17.8 4.1 1.6 1 0 0 1 1 1 1 Centromere protein H (CENP-H) YabA PF06156.13 ELR21886.1 - 0.037 14.7 2.4 0.086 13.5 2.4 1.6 1 0 0 1 1 1 0 Initiation control protein YabA KASH_CCD PF14662.6 ELR21886.1 - 0.19 11.5 7.8 0.08 12.8 3.1 2.1 1 1 1 2 2 2 0 Coiled-coil region of CCDC155 or KASH DivIVA PF05103.13 ELR21886.1 - 0.23 11.5 3.3 0.43 10.7 3.3 1.4 1 0 0 1 1 1 0 DivIVA protein ZapB PF06005.12 ELR21886.1 - 0.32 11.5 7.8 1.1 9.7 7.8 1.9 1 1 0 1 1 1 0 Cell division protein ZapB HAUS-augmin3 PF14932.6 ELR21886.1 - 0.33 10.5 5.8 0.36 10.4 4.4 1.8 2 0 0 2 2 2 0 HAUS augmin-like complex subunit 3 APG6_N PF17675.1 ELR21886.1 - 0.39 11.2 7.1 1.5 9.3 7.1 1.9 1 1 0 1 1 1 0 Apg6 coiled-coil region LPP PF04728.13 ELR21886.1 - 0.74 10.2 4.6 2.2 8.7 4.6 1.8 1 0 0 1 1 1 0 Lipoprotein leucine-zipper GIT_CC PF16559.5 ELR21886.1 - 0.9 9.5 3.5 2 8.4 3.5 1.5 1 0 0 1 1 1 0 GIT coiled-coil Rho guanine nucleotide exchange factor Pkinase_Tyr PF07714.17 ELR21887.1 - 3.3e-68 229.8 0.0 5.9e-68 229.0 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ELR21887.1 - 1.2e-46 159.3 0.0 1.9e-46 158.6 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Roc PF08477.13 ELR21887.1 - 4.3e-14 52.7 0.0 9.9e-14 51.6 0.0 1.7 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase COR PF16095.5 ELR21887.1 - 1e-09 38.5 0.0 0.00052 19.9 0.0 2.5 2 0 0 2 2 2 2 C-terminal of Roc, COR, domain LRR_4 PF12799.7 ELR21887.1 - 1.8e-08 34.5 12.1 0.0022 18.3 6.0 4.4 2 1 2 4 4 4 2 Leucine Rich repeats (2 copies) SAM_1 PF00536.30 ELR21887.1 - 3.1e-08 33.9 0.0 9e-08 32.5 0.0 1.8 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) LRR_6 PF13516.6 ELR21887.1 - 1.4e-07 31.0 15.6 0.00035 20.4 0.4 4.7 5 0 0 5 5 4 2 Leucine Rich repeat LRR_8 PF13855.6 ELR21887.1 - 2.3e-07 30.5 1.9 2.3e-07 30.5 1.9 3.5 3 1 0 3 3 3 1 Leucine rich repeat SAM_2 PF07647.17 ELR21887.1 - 3.6e-05 23.8 0.1 0.00023 21.2 0.0 2.3 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) Ras PF00071.22 ELR21887.1 - 7.5e-05 22.4 0.0 0.0002 21.0 0.0 1.7 1 1 0 1 1 1 1 Ras family Kdo PF06293.14 ELR21887.1 - 0.0012 18.3 0.0 0.003 17.0 0.0 1.6 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Arf PF00025.21 ELR21887.1 - 0.0015 18.0 0.1 0.011 15.2 0.1 2.1 1 1 0 1 1 1 1 ADP-ribosylation factor family Kinase-like PF14531.6 ELR21887.1 - 0.004 16.5 0.0 0.0076 15.6 0.0 1.3 1 0 0 1 1 1 1 Kinase-like AAA_16 PF13191.6 ELR21887.1 - 0.025 15.0 0.0 0.12 12.7 0.0 2.1 1 1 0 1 1 1 0 AAA ATPase domain DLIC PF05783.11 ELR21887.1 - 3 6.6 6.5 0.62 8.8 0.0 3.0 3 0 0 3 3 3 0 Dynein light intermediate chain (DLIC) BAR_3 PF16746.5 ELR21888.1 - 1e-29 103.9 11.4 2e-29 103.0 11.4 1.4 1 0 0 1 1 1 1 BAR domain of APPL family ArfGap PF01412.18 ELR21888.1 - 1.1e-22 80.3 5.2 9e-22 77.3 0.5 3.3 3 1 0 3 3 3 1 Putative GTPase activating protein for Arf Ank_5 PF13857.6 ELR21888.1 - 1.2e-10 41.4 1.8 1.2e-07 31.8 0.1 4.4 3 1 1 4 4 4 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 ELR21888.1 - 8.3e-10 39.1 2.6 2.8e-09 37.4 0.3 2.9 4 0 0 4 4 4 1 Ankyrin repeats (3 copies) BAR PF03114.18 ELR21888.1 - 4.3e-09 36.4 7.6 8.9e-09 35.3 7.6 1.5 1 0 0 1 1 1 1 BAR domain Ank_4 PF13637.6 ELR21888.1 - 1.3e-08 35.2 1.8 2.9e-08 34.1 0.1 2.6 2 1 1 3 3 3 1 Ankyrin repeats (many copies) Ank PF00023.30 ELR21888.1 - 3.5e-06 27.2 1.8 0.096 13.2 0.1 4.2 4 0 0 4 4 4 2 Ankyrin repeat PH PF00169.29 ELR21888.1 - 1.3e-05 25.6 1.5 0.00028 21.4 1.5 2.7 1 1 0 1 1 1 1 PH domain Ank_3 PF13606.6 ELR21888.1 - 2.7e-05 24.2 0.7 0.042 14.4 0.1 3.4 3 0 0 3 3 3 1 Ankyrin repeat PH_11 PF15413.6 ELR21888.1 - 0.59 10.6 6.1 1.8 9.0 1.4 3.1 2 1 0 2 2 2 0 Pleckstrin homology domain Ras PF00071.22 ELR21889.1 - 8.8e-55 184.7 0.0 1e-54 184.5 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR21889.1 - 5.2e-21 75.1 0.0 8e-21 74.5 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR21889.1 - 1.9e-08 34.0 0.0 2.3e-08 33.7 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family AIM5 PF17050.5 ELR21889.1 - 0.084 13.7 0.0 2.8 8.8 0.0 2.2 2 0 0 2 2 2 0 Altered inheritance of mitochondria 5 V-ATPase_G PF03179.15 ELR21890.1 - 1.7e-24 86.4 14.3 1.9e-24 86.2 14.3 1.0 1 0 0 1 1 1 1 Vacuolar (H+)-ATPase G subunit V-ATPase_G_2 PF16999.5 ELR21890.1 - 0.0018 18.6 13.7 0.0021 18.4 13.7 1.0 1 0 0 1 1 1 1 Vacuolar (H+)-ATPase G subunit DUF3552 PF12072.8 ELR21890.1 - 0.027 13.9 17.9 0.049 13.1 17.8 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF3552) ATP-synt_B PF00430.18 ELR21890.1 - 4.3 7.4 19.3 1.1 9.4 14.6 1.9 1 1 1 2 2 2 0 ATP synthase B/B' CF(0) HHV-5_US34A PF17087.5 ELR21890.1 - 7.9 6.7 5.9 2.7 8.2 1.2 2.2 1 1 1 2 2 2 0 Herpesvirus US34A protein family Rhomboid PF01694.22 ELR21891.1 - 1.4e-20 73.8 15.9 2.5e-20 73.0 15.9 1.4 1 0 0 1 1 1 1 Rhomboid family DER1 PF04511.15 ELR21891.1 - 1.3e-09 38.2 13.1 2.3e-09 37.5 13.1 1.3 1 1 0 1 1 1 1 Der1-like family DUF1751 PF08551.10 ELR21891.1 - 0.00099 19.6 1.8 0.00099 19.6 1.8 2.5 2 1 0 2 2 2 1 Eukaryotic integral membrane protein (DUF1751) SKA2 PF16740.5 ELR21892.1 - 0.00089 19.0 0.5 0.0021 17.8 0.5 1.5 1 0 0 1 1 1 1 Spindle and kinetochore-associated protein 2 RRP7 PF12923.7 ELR21892.1 - 0.023 14.9 0.3 0.023 14.9 0.3 2.7 3 0 0 3 3 3 0 Ribosomal RNA-processing protein 7 (RRP7) C-terminal domain CCDC106 PF15794.5 ELR21892.1 - 0.11 12.2 9.4 0.25 11.0 9.4 1.5 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 MFMR_assoc PF16596.5 ELR21892.1 - 0.22 12.0 11.6 2.7 8.5 10.4 2.2 2 0 0 2 2 2 0 Disordered region downstream of MFMR XAP5 PF04921.14 ELR21892.1 - 0.3 10.9 9.4 0.71 9.7 9.4 1.6 1 0 0 1 1 1 0 XAP5, circadian clock regulator TLP-20 PF06088.11 ELR21892.1 - 0.68 9.8 4.3 1.6 8.6 4.3 1.6 1 0 0 1 1 1 0 Nucleopolyhedrovirus telokin-like protein-20 (TLP20) CDC45 PF02724.14 ELR21892.1 - 1.7 6.8 14.0 3.1 6.0 14.0 1.3 1 0 0 1 1 1 0 CDC45-like protein CobT PF06213.12 ELR21892.1 - 3.8 6.8 14.8 8 5.8 14.8 1.4 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Sigma70_ner PF04546.13 ELR21892.1 - 4.1 7.2 12.6 0.92 9.3 0.7 2.4 2 0 0 2 2 2 0 Sigma-70, non-essential region SATase_N PF06426.14 ELR21896.1 - 0.023 15.1 0.3 0.048 14.0 0.3 1.5 1 0 0 1 1 1 0 Serine acetyltransferase, N-terminal zf-RVT PF13966.6 ELR21896.1 - 0.12 13.1 0.2 0.28 11.9 0.2 1.6 1 0 0 1 1 1 0 zinc-binding in reverse transcriptase LMSTEN PF07988.12 ELR21896.1 - 0.27 10.7 1.1 0.51 9.8 1.1 1.4 1 0 0 1 1 1 0 LMSTEN motif Cupin_8 PF13621.6 ELR21897.1 - 2.1e-32 112.8 0.4 1.3e-31 110.3 0.2 2.2 2 1 0 2 2 2 1 Cupin-like domain Cupin_4 PF08007.12 ELR21897.1 - 2.7e-06 27.1 0.1 1.1e-05 25.1 0.1 1.8 1 1 0 1 1 1 1 Cupin superfamily protein JmjC PF02373.22 ELR21897.1 - 0.0034 17.8 0.0 0.0061 17.0 0.0 1.4 1 0 0 1 1 1 1 JmjC domain, hydroxylase Cupin_1 PF00190.22 ELR21897.1 - 0.073 12.7 0.0 0.15 11.7 0.0 1.4 1 0 0 1 1 1 0 Cupin INCENP_ARK-bind PF03941.15 ELR21897.1 - 0.074 13.0 0.1 0.22 11.5 0.1 1.8 1 0 0 1 1 1 0 Inner centromere protein, ARK binding region Cupin_2 PF07883.11 ELR21897.1 - 0.11 12.2 0.0 0.69 9.7 0.0 2.2 2 0 0 2 2 2 0 Cupin domain Kazal_1 PF00050.21 ELR21897.1 - 0.14 12.2 0.9 0.27 11.3 0.9 1.4 1 0 0 1 1 1 0 Kazal-type serine protease inhibitor domain Ish1 PF10281.9 ELR21897.1 - 0.21 11.9 0.9 36 4.8 0.0 3.5 3 0 0 3 3 3 0 Putative stress-responsive nuclear envelope protein GTP_EFTU PF00009.27 ELR21898.1 - 9.1e-07 28.6 0.0 0.018 14.6 0.0 2.2 2 0 0 2 2 2 2 Elongation factor Tu GTP binding domain Spore_IV_A PF09547.10 ELR21898.1 - 0.07 12.1 0.0 0.34 9.8 0.0 1.8 2 0 0 2 2 2 0 Stage IV sporulation protein A (spore_IV_A) PH PF00169.29 ELR21899.1 - 0.044 14.3 0.0 0.077 13.5 0.0 1.4 1 0 0 1 1 1 0 PH domain RA PF00788.23 ELR21900.1 - 3.7e-08 33.9 0.0 8.1e-08 32.8 0.0 1.6 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain DAGAT PF03982.13 ELR21901.1 - 7.4e-65 218.8 0.0 8.9e-65 218.5 0.0 1.1 1 0 0 1 1 1 1 Diacylglycerol acyltransferase DUF3964 PF13107.6 ELR21901.1 - 0.074 13.5 0.0 0.14 12.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3964) PIG-P PF08510.12 ELR21903.1 - 0.022 14.7 1.9 0.035 14.0 1.9 1.4 1 1 0 1 1 1 0 PIG-P Tetraspanin PF00335.20 ELR21903.1 - 0.29 10.8 7.6 0.5 10.0 7.7 1.4 1 1 0 1 1 1 0 Tetraspanin family Ank_2 PF12796.7 ELR21904.1 - 2e-28 98.8 0.0 2.3e-13 50.5 0.1 3.0 1 1 2 3 3 3 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ELR21904.1 - 2.4e-23 82.2 1.2 7.5e-06 26.4 0.1 4.2 2 1 2 4 4 4 4 Ankyrin repeats (many copies) Ank_5 PF13857.6 ELR21904.1 - 4.6e-22 77.8 4.2 1.9e-09 37.6 0.2 3.9 1 1 3 4 4 4 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 ELR21904.1 - 1.2e-18 65.3 1.0 0.0014 19.0 0.0 5.7 6 0 0 6 6 6 4 Ankyrin repeat Ank PF00023.30 ELR21904.1 - 2.9e-18 65.4 7.3 0.0044 17.4 0.0 5.8 6 0 0 6 6 6 4 Ankyrin repeat Pertactin PF03212.14 ELR21904.1 - 0.16 11.9 0.1 0.37 10.7 0.0 1.6 2 0 0 2 2 2 0 Pertactin DUF836 PF05768.14 ELR21905.1 - 1.3e-08 35.1 0.5 7.5e-08 32.7 0.5 1.8 1 1 0 1 1 1 1 Glutaredoxin-like domain (DUF836) Glutaredoxin PF00462.24 ELR21905.1 - 0.0018 18.4 0.5 0.0036 17.5 0.5 1.7 1 1 0 1 1 1 1 Glutaredoxin Thioredoxin_2 PF13098.6 ELR21905.1 - 0.069 13.6 0.5 0.08 13.4 0.5 1.3 1 1 0 1 1 1 0 Thioredoxin-like domain LIM PF00412.22 ELR21906.1 - 1.2e-09 38.2 9.3 2.1e-09 37.5 9.3 1.4 1 0 0 1 1 1 1 LIM domain zf-RRN7 PF11781.8 ELR21906.1 - 0.0061 16.2 0.6 0.0061 16.2 0.6 1.9 2 0 0 2 2 2 1 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 LCD1 PF09798.9 ELR21906.1 - 0.053 12.0 5.6 0.065 11.8 5.6 1.1 1 0 0 1 1 1 0 DNA damage checkpoint protein Jnk-SapK_ap_N PF09744.9 ELR21906.1 - 0.22 11.8 10.4 0.38 11.0 10.4 1.3 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 APG6_N PF17675.1 ELR21906.1 - 3.2 8.3 18.5 9.2 6.8 18.5 1.9 1 1 0 1 1 1 0 Apg6 coiled-coil region TPR_MLP1_2 PF07926.12 ELR21906.1 - 4.3 7.4 18.9 9.1 6.4 18.9 1.5 1 1 0 1 1 1 0 TPR/MLP1/MLP2-like protein DnaJ PF00226.31 ELR21908.1 - 3.7e-16 59.0 0.0 5.4e-16 58.5 0.0 1.3 1 0 0 1 1 1 1 DnaJ domain DUF4064 PF13273.6 ELR21908.1 - 0.066 13.5 3.7 0.31 11.3 2.4 2.4 2 1 1 3 3 3 0 Protein of unknown function (DUF4064) Macoilin PF09726.9 ELR21908.1 - 0.22 10.1 1.0 0.33 9.4 1.0 1.2 1 0 0 1 1 1 0 Macoilin family RXLR PF16810.5 ELR21908.1 - 0.84 10.1 2.1 9.6 6.6 0.8 2.1 1 1 1 2 2 2 0 RXLR phytopathogen effector protein, Avirulence activity DUF4381 PF14316.6 ELR21908.1 - 8 6.7 7.2 1.8 8.8 0.2 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF4381) PIG-F PF06699.11 ELR21909.1 - 5.5e-12 46.2 6.8 6.7e-12 45.9 6.1 1.5 1 1 1 2 2 2 1 GPI biosynthesis protein family Pig-F DHR-2 PF06920.13 ELR21910.1 - 2.2e-154 515.0 0.3 3e-154 514.6 0.3 1.1 1 0 0 1 1 1 1 Dock homology region 2 DOCK-C2 PF14429.6 ELR21910.1 - 4.4e-45 153.9 0.0 5.6e-44 150.3 0.0 2.2 2 0 0 2 2 2 1 C2 domain in Dock180 and Zizimin proteins DUF3398 PF11878.8 ELR21910.1 - 6.9e-09 36.1 0.0 1.7e-08 34.9 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3398) TPR_7 PF13176.6 ELR21910.1 - 0.078 13.0 0.1 0.7 10.1 0.0 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_10 PF13374.6 ELR21910.1 - 0.12 12.3 0.0 0.34 10.8 0.0 1.8 1 0 0 1 1 1 0 Tetratricopeptide repeat HALZ PF02183.18 ELR21910.1 - 0.19 12.0 2.3 0.56 10.5 0.1 2.6 2 0 0 2 2 2 0 Homeobox associated leucine zipper Med3 PF11593.8 ELR21911.1 - 0.051 12.8 15.7 0.079 12.1 15.7 1.2 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal ATF7IP_BD PF16788.5 ELR21911.1 - 3.2 7.8 6.6 4.8 7.2 6.6 1.2 1 0 0 1 1 1 0 ATF-interacting protein binding domain Flavin_Reduct PF01613.18 ELR21913.1 - 1.3e-10 41.5 0.0 2.2e-10 40.8 0.0 1.3 1 0 0 1 1 1 1 Flavin reductase like domain p450 PF00067.22 ELR21914.1 - 2.2e-60 204.7 0.0 4.3e-60 203.8 0.0 1.3 1 1 0 1 1 1 1 Cytochrome P450 LTD PF00932.19 ELR21915.1 - 2.3e-21 76.2 0.5 8.1e-14 51.9 0.1 2.4 2 1 0 2 2 2 2 Lamin Tail Domain CactinC_cactus PF09732.9 ELR21916.1 - 5.5e-60 200.8 10.6 1.3e-59 199.6 10.6 1.7 1 0 0 1 1 1 1 Cactus-binding C-terminus of cactin protein Cactin_mid PF10312.9 ELR21916.1 - 5.2e-59 199.3 5.7 5.2e-59 199.3 5.7 2.7 3 0 0 3 3 3 1 Conserved mid region of cactin Myosin_head PF00063.21 ELR21917.1 - 2.4e-236 786.2 4.9 3.2e-236 785.7 4.9 1.2 1 0 0 1 1 1 1 Myosin head (motor domain) MyTH4 PF00784.17 ELR21917.1 - 1.3e-19 70.6 0.0 4e-19 69.1 0.0 1.7 1 0 0 1 1 1 1 MyTH4 domain SH3_9 PF14604.6 ELR21917.1 - 3.9e-08 33.0 0.1 1.1e-07 31.6 0.1 1.9 1 0 0 1 1 1 1 Variant SH3 domain WW PF00397.26 ELR21917.1 - 3.9e-07 30.0 3.0 1.2e-06 28.5 3.0 1.8 1 0 0 1 1 1 1 WW domain SH3_2 PF07653.17 ELR21917.1 - 0.0017 18.0 0.7 0.0038 16.9 0.1 1.9 2 0 0 2 2 2 1 Variant SH3 domain Myosin_N PF02736.19 ELR21917.1 - 0.0033 17.2 0.1 0.025 14.4 0.0 2.4 2 0 0 2 2 2 1 Myosin N-terminal SH3-like domain Hpr_kinase_C PF07475.12 ELR21917.1 - 0.041 13.4 0.4 15 5.1 0.0 3.0 2 0 0 2 2 2 0 HPr Serine kinase C-terminal domain AAA_16 PF13191.6 ELR21917.1 - 0.042 14.2 3.9 0.25 11.7 0.0 3.5 3 0 0 3 3 3 0 AAA ATPase domain AAA_22 PF13401.6 ELR21917.1 - 0.12 12.6 0.0 0.76 10.0 0.0 2.4 1 0 0 1 1 1 0 AAA domain Kelch_4 PF13418.6 ELR21918.1 - 3.7e-25 87.7 19.5 2.9e-05 24.0 0.2 8.0 7 0 0 7 7 7 6 Galactose oxidase, central domain Kelch_1 PF01344.25 ELR21918.1 - 1.3e-19 69.4 15.8 0.0013 18.2 0.1 6.8 6 0 0 6 6 6 5 Kelch motif Kelch_6 PF13964.6 ELR21918.1 - 4.7e-18 64.8 23.1 0.005 17.1 0.2 7.5 6 1 1 7 7 7 6 Kelch motif Kelch_3 PF13415.6 ELR21918.1 - 1.5e-07 31.5 30.9 0.033 14.5 0.7 7.4 7 0 0 7 7 7 5 Galactose oxidase, central domain Kelch_2 PF07646.15 ELR21918.1 - 7.5e-06 25.7 15.4 0.29 11.2 0.0 6.9 8 0 0 8 8 8 3 Kelch motif Nterm_IS4 PF13006.7 ELR21918.1 - 0.00018 21.6 5.7 1.9 8.7 0.0 6.1 4 1 4 8 8 8 1 Insertion element 4 transposase N-terminal HTH_55 PF18622.1 ELR21918.1 - 1.1 9.7 4.2 45 4.4 0.0 3.8 2 1 3 5 5 5 0 RctB helix turn helix domain DUF3684 PF12449.8 ELR21919.1 - 6.4e-131 438.2 0.7 3e-77 260.5 0.1 4.5 4 1 0 4 4 4 4 Protein of unknown function (DUF3684) HATPase_c_3 PF13589.6 ELR21919.1 - 0.031 14.1 0.0 1.1 9.0 0.0 2.6 2 0 0 2 2 2 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Phage_holin_3_6 PF07332.11 ELR21921.1 - 0.47 10.5 20.2 0.085 12.9 3.0 2.7 1 1 2 3 3 3 0 Putative Actinobacterial Holin-X, holin superfamily III IBN_N PF03810.19 ELR21922.1 - 5e-10 39.1 1.0 1.7e-09 37.4 0.2 2.4 2 0 0 2 2 2 1 Importin-beta N-terminal domain UME PF08064.13 ELR21922.1 - 0.1 12.5 4.3 2.3 8.2 0.1 4.2 4 1 1 5 5 5 0 UME (NUC010) domain Ribosomal_L20 PF00453.18 ELR21923.1 - 3.9e-35 120.2 0.7 3.9e-35 120.2 0.7 1.5 2 0 0 2 2 2 1 Ribosomal protein L20 Cupin_8 PF13621.6 ELR21924.1 - 4.4e-16 59.4 0.0 1.1e-15 58.1 0.0 1.6 1 1 0 1 1 1 1 Cupin-like domain JmjC PF02373.22 ELR21924.1 - 1.4e-10 41.6 0.2 3.9e-10 40.2 0.0 1.9 2 0 0 2 2 2 1 JmjC domain, hydroxylase F-box-like PF12937.7 ELR21924.1 - 1.7e-08 34.2 0.0 3.6e-08 33.2 0.0 1.5 1 0 0 1 1 1 1 F-box-like zf-UBR PF02207.20 ELR21924.1 - 9e-07 29.0 12.6 1.8e-06 28.0 12.6 1.4 1 0 0 1 1 1 1 Putative zinc finger in N-recognin (UBR box) F-box PF00646.33 ELR21924.1 - 1.8e-05 24.5 0.0 4.3e-05 23.3 0.0 1.6 1 0 0 1 1 1 1 F-box domain RR_TM4-6 PF06459.12 ELR21924.1 - 0.057 13.3 0.0 0.085 12.7 0.0 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 RRN3 PF05327.11 ELR21924.1 - 0.19 10.2 3.2 0.24 9.9 3.2 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 BUD22 PF09073.10 ELR21924.1 - 0.29 10.4 8.1 0.42 9.9 8.1 1.1 1 0 0 1 1 1 0 BUD22 SDA1 PF05285.12 ELR21924.1 - 0.66 9.3 12.5 0.99 8.8 12.5 1.2 1 0 0 1 1 1 0 SDA1 Trypan_PARP PF05887.11 ELR21924.1 - 2.4 8.1 12.7 4.2 7.3 12.7 1.3 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) Pox_Ag35 PF03286.14 ELR21924.1 - 3.3 7.5 8.6 5.2 6.8 8.6 1.2 1 0 0 1 1 1 0 Pox virus Ag35 surface protein TRAP_alpha PF03896.16 ELR21924.1 - 8.8 5.4 6.5 13 4.8 6.5 1.2 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit DinB PF05163.12 ELR21925.1 - 1.4e-23 83.7 3.4 1.7e-23 83.4 3.4 1.0 1 0 0 1 1 1 1 DinB family DinB_2 PF12867.7 ELR21925.1 - 4.3e-12 46.7 2.5 5.3e-12 46.4 2.5 1.0 1 0 0 1 1 1 1 DinB superfamily DUF664 PF04978.12 ELR21925.1 - 0.011 16.1 1.6 0.023 15.1 1.6 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF664) ABC2_membrane PF01061.24 ELR21926.1 - 1.2e-77 260.0 36.7 1.8e-42 145.1 20.8 2.6 2 0 0 2 2 2 2 ABC-2 type transporter ABC_tran PF00005.27 ELR21926.1 - 3.2e-49 167.0 0.1 1.4e-25 90.4 0.0 2.7 2 0 0 2 2 2 2 ABC transporter RsgA_GTPase PF03193.16 ELR21926.1 - 8e-09 35.6 0.4 0.0014 18.5 0.1 2.4 2 0 0 2 2 2 2 RsgA GTPase AAA_21 PF13304.6 ELR21926.1 - 2e-08 34.4 0.2 1.2 8.9 0.1 4.3 3 1 1 4 4 4 3 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 ELR21926.1 - 7.1e-08 32.1 0.7 0.0061 16.3 0.1 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_16 PF13191.6 ELR21926.1 - 6.3e-07 29.9 0.0 0.033 14.6 0.0 2.7 2 0 0 2 2 2 2 AAA ATPase domain AAA_22 PF13401.6 ELR21926.1 - 1.5e-05 25.3 0.3 0.37 11.1 0.0 3.0 3 1 0 3 3 2 2 AAA domain AAA_18 PF13238.6 ELR21926.1 - 2.7e-05 24.7 0.0 0.32 11.5 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_25 PF13481.6 ELR21926.1 - 3.8e-05 23.3 0.2 0.3 10.6 0.0 2.5 2 0 0 2 2 2 2 AAA domain MMR_HSR1 PF01926.23 ELR21926.1 - 5.3e-05 23.3 0.1 0.24 11.5 0.0 2.6 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_33 PF13671.6 ELR21926.1 - 0.00036 20.7 0.4 1.1 9.4 0.0 2.7 2 0 0 2 2 2 2 AAA domain Rad17 PF03215.15 ELR21926.1 - 0.0014 18.5 0.1 0.55 10.1 0.0 2.5 2 0 0 2 2 2 1 Rad17 P-loop domain RNA_helicase PF00910.22 ELR21926.1 - 0.0017 18.8 0.1 2.7 8.4 0.0 2.8 2 0 0 2 2 2 1 RNA helicase AAA_28 PF13521.6 ELR21926.1 - 0.0026 18.0 4.8 0.79 9.9 0.3 3.2 3 0 0 3 3 3 2 AAA domain AAA_14 PF13173.6 ELR21926.1 - 0.0037 17.3 0.1 0.27 11.3 0.0 2.5 2 0 0 2 2 2 1 AAA domain DUF87 PF01935.17 ELR21926.1 - 0.0047 17.0 3.9 0.55 10.3 0.3 3.2 3 0 0 3 3 3 1 Helicase HerA, central domain DUF815 PF05673.13 ELR21926.1 - 0.005 16.0 1.4 1.1 8.4 0.0 3.0 3 0 0 3 3 3 1 Protein of unknown function (DUF815) AAA_23 PF13476.6 ELR21926.1 - 0.0052 17.3 0.2 4.2 7.8 0.0 2.7 2 0 0 2 2 2 1 AAA domain AAA PF00004.29 ELR21926.1 - 0.0056 17.1 0.4 0.97 9.9 0.0 3.2 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Zeta_toxin PF06414.12 ELR21926.1 - 0.0077 15.5 0.8 2.6 7.3 0.0 2.4 2 0 0 2 2 2 1 Zeta toxin AAA_30 PF13604.6 ELR21926.1 - 0.0079 15.9 0.1 4.3 7.0 0.0 2.4 2 0 0 2 2 2 1 AAA domain cobW PF02492.19 ELR21926.1 - 0.01 15.4 0.8 2 8.0 0.0 2.4 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Viral_helicase1 PF01443.18 ELR21926.1 - 0.025 14.3 0.3 0.14 11.9 0.0 2.2 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase AAA_5 PF07728.14 ELR21926.1 - 0.029 14.4 1.8 2.1 8.4 0.3 3.0 3 0 0 3 3 2 0 AAA domain (dynein-related subfamily) G-alpha PF00503.20 ELR21926.1 - 0.03 13.5 0.1 6.1 5.9 0.0 2.3 2 0 0 2 2 2 0 G-protein alpha subunit Ploopntkinase3 PF18751.1 ELR21926.1 - 0.031 14.2 1.0 7.6 6.4 0.1 2.7 2 0 0 2 2 2 0 P-loop Nucleotide Kinase3 NACHT PF05729.12 ELR21926.1 - 0.048 13.6 3.8 1.3 8.9 0.2 2.4 2 0 0 2 2 2 0 NACHT domain Roc PF08477.13 ELR21926.1 - 0.053 13.7 0.3 14 5.9 0.0 2.6 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase PDR_CDR PF06422.12 ELR21926.1 - 0.09 12.7 9.2 1.9 8.4 0.0 3.7 3 0 0 3 3 3 0 CDR ABC transporter AAA_17 PF13207.6 ELR21926.1 - 0.16 12.4 1.5 12 6.3 0.3 2.7 2 0 0 2 2 2 0 AAA domain MeaB PF03308.16 ELR21926.1 - 0.16 10.9 0.6 15 4.5 0.0 2.3 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_24 PF13479.6 ELR21926.1 - 0.24 11.1 2.8 10 5.7 0.3 2.5 2 0 0 2 2 2 0 AAA domain APS_kinase PF01583.20 ELR21926.1 - 0.49 10.3 1.5 0.86 9.5 0.0 2.1 3 0 0 3 3 2 0 Adenylylsulphate kinase PduV-EutP PF10662.9 ELR21926.1 - 0.56 9.9 1.7 30 4.3 0.1 2.4 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation NB-ARC PF00931.22 ELR21926.1 - 0.87 8.7 2.3 18 4.4 0.3 2.3 2 0 0 2 2 2 0 NB-ARC domain AICARFT_IMPCHas PF01808.18 ELR21927.1 - 1.1e-104 350.0 0.0 1.4e-104 349.7 0.0 1.1 1 0 0 1 1 1 1 AICARFT/IMPCHase bienzyme MGS PF02142.22 ELR21927.1 - 5.4e-26 90.6 0.1 1e-25 89.7 0.1 1.5 1 0 0 1 1 1 1 MGS-like domain DNA_methylase PF00145.17 ELR21928.1 - 3.2e-09 36.6 0.0 3.2e-09 36.6 0.0 3.0 3 0 0 3 3 3 1 C-5 cytosine-specific DNA methylase SpecificRecomb PF10136.9 ELR21928.1 - 0.11 10.8 0.6 0.16 10.2 0.6 1.3 1 0 0 1 1 1 0 Site-specific recombinase AT_hook PF02178.19 ELR21928.1 - 0.61 10.2 5.4 2.4 8.3 5.4 2.1 1 0 0 1 1 1 0 AT hook motif T4_deiodinase PF00837.17 ELR21929.1 - 3e-14 52.9 0.0 6.8e-14 51.7 0.0 1.6 1 1 0 1 1 1 1 Iodothyronine deiodinase DUF420 PF04238.12 ELR21930.1 - 0.0066 16.7 0.2 0.0066 16.7 0.2 2.3 1 1 1 2 2 2 1 Protein of unknown function (DUF420) DUF2306 PF10067.9 ELR21930.1 - 0.01 16.1 9.6 0.01 16.1 9.6 1.9 2 0 0 2 2 2 1 Predicted membrane protein (DUF2306) Myb_DNA-bind_2 PF08914.11 ELR21930.1 - 0.055 13.7 0.5 12 6.2 0.0 2.3 2 0 0 2 2 2 0 Rap1 Myb domain DUF5316 PF17247.2 ELR21930.1 - 0.56 10.2 4.0 8.2 6.5 0.0 3.3 4 0 0 4 4 4 0 Family of unknown function (DUF5316) NTP_transf_2 PF01909.23 ELR21931.1 - 0.0016 18.7 0.0 0.0035 17.6 0.0 1.5 1 0 0 1 1 1 1 Nucleotidyltransferase domain Polbeta PF18765.1 ELR21931.1 - 0.0021 18.1 0.0 0.005 16.9 0.0 1.6 1 0 0 1 1 1 1 Polymerase beta, Nucleotidyltransferase Gag_p12 PF01141.18 ELR21931.1 - 0.043 14.1 0.1 1.7 9.0 0.1 2.8 2 0 0 2 2 2 0 Gag polyprotein, inner coat protein p12 Rho_N PF07498.12 ELR21932.1 - 0.048 13.6 0.0 0.096 12.6 0.0 1.4 1 0 0 1 1 1 0 Rho termination factor, N-terminal domain TPR_14 PF13428.6 ELR21932.1 - 0.15 13.0 2.6 0.79 10.7 0.3 3.3 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_2 PF07719.17 ELR21932.1 - 0.27 11.4 3.2 1.3 9.4 0.0 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat Aldo_ket_red PF00248.21 ELR21933.1 - 4e-69 233.1 0.0 4.6e-69 232.9 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Mito_carr PF00153.27 ELR21934.1 - 3.4e-63 209.6 2.1 4.8e-20 71.3 0.2 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein EF-hand_7 PF13499.6 ELR21934.1 - 5.4e-05 23.6 0.6 0.00015 22.1 0.2 1.8 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.6 ELR21934.1 - 0.00011 21.9 0.1 0.00025 20.7 0.1 1.6 1 0 0 1 1 1 1 EF-hand domain EF-hand_1 PF00036.32 ELR21934.1 - 0.001 18.5 1.0 0.0017 17.7 0.1 1.9 2 0 0 2 2 2 1 EF hand EF-hand_8 PF13833.6 ELR21934.1 - 0.0061 16.4 0.0 0.017 15.0 0.0 1.8 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_9 PF14658.6 ELR21934.1 - 0.014 15.7 0.0 0.063 13.6 0.0 2.1 2 1 0 2 2 2 0 EF-hand domain Serine_protease PF18405.1 ELR21934.1 - 0.024 13.8 0.3 4.7 6.3 0.1 2.6 2 1 0 3 3 3 0 Gammaproteobacterial serine protease AAA PF00004.29 ELR21935.1 - 2.4e-17 63.6 0.9 7.7e-17 62.0 0.0 2.3 3 0 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 ELR21935.1 - 0.0012 19.3 0.5 0.0058 17.0 0.5 2.4 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 ELR21935.1 - 0.0018 18.6 1.9 0.011 16.0 0.1 2.6 2 1 1 3 3 3 1 AAA domain AAA_5 PF07728.14 ELR21935.1 - 0.0035 17.3 0.0 0.0084 16.1 0.0 1.7 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 ELR21935.1 - 0.0082 16.3 0.0 0.023 14.8 0.0 1.7 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) Zot PF05707.12 ELR21935.1 - 0.011 15.4 0.2 0.2 11.3 0.1 2.5 1 1 0 2 2 2 0 Zonular occludens toxin (Zot) PCRF PF03462.18 ELR21935.1 - 0.016 15.0 2.1 0.041 13.7 2.1 1.6 1 0 0 1 1 1 0 PCRF domain Vps36_ESCRT-II PF11605.8 ELR21935.1 - 0.022 15.0 0.0 0.052 13.7 0.0 1.6 1 0 0 1 1 1 0 Vacuolar protein sorting protein 36 Vps36 CbiA PF01656.23 ELR21935.1 - 0.044 13.8 0.0 0.12 12.4 0.0 1.8 1 0 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain Mg_chelatase PF01078.21 ELR21935.1 - 0.05 13.0 0.2 0.2 11.0 0.1 2.0 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI MCM_lid PF17855.1 ELR21935.1 - 0.16 12.4 0.0 0.36 11.3 0.0 1.6 1 0 0 1 1 1 0 MCM AAA-lid domain AAA_11 PF13086.6 ELR21935.1 - 0.19 11.5 0.7 3.7 7.2 0.0 2.2 2 0 0 2 2 2 0 AAA domain COMP PF11598.8 ELR21935.1 - 0.23 11.9 1.1 0.57 10.7 1.1 1.7 1 0 0 1 1 1 0 Cartilage oligomeric matrix protein RCC1 PF00415.18 ELR21936.1 - 1.5e-48 163.2 16.3 1.6e-15 57.4 0.4 6.9 6 2 0 6 6 6 6 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 ELR21936.1 - 5.2e-27 93.0 33.9 1.2e-07 31.3 2.6 7.4 7 0 0 7 7 7 7 Regulator of chromosome condensation (RCC1) repeat PapC_C PF13953.6 ELR21936.1 - 0.015 15.1 4.3 7.1 6.5 0.1 3.7 4 0 0 4 4 4 0 PapC C-terminal domain NHL PF01436.21 ELR21936.1 - 0.082 13.0 1.2 5.9 7.1 0.2 3.5 3 0 0 3 3 3 0 NHL repeat MFS_1 PF07690.16 ELR21937.1 - 2.5e-16 59.5 37.1 4.9e-10 38.9 13.8 3.3 1 1 2 3 3 3 3 Major Facilitator Superfamily Nodulin-like PF06813.13 ELR21937.1 - 4.4e-16 59.1 17.8 4.4e-16 59.1 17.8 3.8 4 1 0 4 4 4 1 Nodulin-like Homeodomain PF00046.29 ELR21938.1 - 2.5e-18 65.7 4.5 9.3e-18 63.8 4.5 2.1 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 ELR21938.1 - 2.9e-06 27.1 0.1 1.4e-05 24.9 0.1 2.2 1 0 0 1 1 1 1 Homeobox KN domain ECH_1 PF00378.20 ELR21939.1 - 5.7e-26 91.3 0.0 6.9e-26 91.1 0.0 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 ELR21939.1 - 7.6e-08 32.2 0.1 1e-07 31.8 0.1 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase FSH1 PF03959.13 ELR21940.1 - 1.6e-40 139.0 0.0 2.1e-40 138.7 0.0 1.1 1 0 0 1 1 1 1 Serine hydrolase (FSH1) Abhydrolase_1 PF00561.20 ELR21940.1 - 3.5e-07 30.1 0.3 0.0034 17.1 0.0 2.4 2 1 0 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 ELR21940.1 - 0.011 16.3 1.3 0.35 11.4 0.1 2.1 1 1 1 2 2 2 0 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 ELR21940.1 - 0.069 12.4 0.0 0.73 9.0 0.0 2.2 2 1 1 3 3 3 0 Serine aminopeptidase, S33 IgaA PF07095.11 ELR21940.1 - 0.075 11.0 0.0 0.099 10.6 0.0 1.0 1 0 0 1 1 1 0 Intracellular growth attenuator protein IgaA YL1 PF05764.13 ELR21941.1 - 0.0072 16.5 22.0 0.0093 16.1 22.0 1.1 1 0 0 1 1 1 1 YL1 nuclear protein TFIIF_alpha PF05793.12 ELR21941.1 - 0.066 11.8 29.6 0.081 11.5 29.6 1.0 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) CD20 PF04103.15 ELR21941.1 - 0.49 10.5 3.6 16 5.5 3.6 2.8 1 1 0 1 1 1 0 CD20-like family SDA1 PF05285.12 ELR21941.1 - 0.6 9.5 21.0 0.77 9.1 21.0 1.1 1 0 0 1 1 1 0 SDA1 GREB1 PF15782.5 ELR21941.1 - 1.1 6.3 16.8 1.4 6.0 16.8 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Macoilin PF09726.9 ELR21941.1 - 4.5 5.7 17.0 5.5 5.4 17.0 1.1 1 0 0 1 1 1 0 Macoilin family DUF908 PF06012.12 ELR21941.1 - 5.3 6.4 16.7 6.4 6.1 16.7 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF908) Ank_3 PF13606.6 ELR21943.1 - 3.3e-12 45.5 0.4 2.4e-05 24.3 0.0 3.2 3 0 0 3 3 3 2 Ankyrin repeat Ank_5 PF13857.6 ELR21943.1 - 6.2e-11 42.3 2.2 6.7e-05 23.1 0.1 3.1 2 1 0 3 3 3 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 ELR21943.1 - 1.3e-10 41.7 0.1 5.2e-10 39.8 0.1 1.9 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank PF00023.30 ELR21943.1 - 7.6e-08 32.5 6.0 0.018 15.5 0.0 3.7 4 0 0 4 4 4 2 Ankyrin repeat Ank_4 PF13637.6 ELR21943.1 - 2.1e-05 25.0 0.1 0.22 12.1 0.1 3.5 3 1 1 4 4 4 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 ELR21944.1 - 1.4e-42 144.1 18.3 7.8e-10 39.2 0.8 9.0 5 3 3 8 8 8 6 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ELR21944.1 - 1.5e-42 143.4 20.9 9.5e-10 38.8 0.4 10.8 10 2 2 12 12 12 9 Ankyrin repeats (many copies) Ank_3 PF13606.6 ELR21944.1 - 1.1e-40 133.0 22.2 1.5e-05 25.0 0.1 14.2 14 1 1 15 15 15 7 Ankyrin repeat Ank PF00023.30 ELR21944.1 - 2.5e-40 135.2 37.7 1.7e-06 28.2 0.7 15.1 16 0 0 16 16 16 8 Ankyrin repeat Ank_5 PF13857.6 ELR21944.1 - 5e-31 106.4 28.2 2.4e-05 24.5 0.4 10.0 8 2 2 10 10 10 6 Ankyrin repeats (many copies) F-box-like PF12937.7 ELR21945.1 - 1.9e-06 27.6 0.1 4.3e-06 26.5 0.1 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ELR21945.1 - 0.0081 16.0 0.4 0.03 14.2 0.2 2.0 2 0 0 2 2 2 1 F-box domain Thyroglob_assoc PF16597.5 ELR21945.1 - 0.1 13.0 0.0 1.3 9.4 0.0 2.1 2 0 0 2 2 2 0 Thyroglobulin_1 repeat associated disordered domain tRNA-synt_1 PF00133.22 ELR21946.1 - 4.8e-191 636.1 0.0 6.1e-190 632.4 0.0 2.0 1 1 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 ELR21946.1 - 1.4e-34 119.2 0.1 3.3e-34 118.1 0.1 1.6 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.11 ELR21946.1 - 1e-15 57.4 0.9 1.8e-07 30.3 0.1 4.7 4 1 0 4 4 4 3 tRNA synthetases class I (M) Val_tRNA-synt_C PF10458.9 ELR21946.1 - 8.3e-08 32.4 8.1 8.3e-08 32.4 8.1 2.3 3 0 0 3 3 3 1 Valyl tRNA synthetase tRNA binding arm tRNA-synt_1_2 PF13603.6 ELR21946.1 - 2.4e-07 30.5 0.0 0.00017 21.2 0.0 2.7 1 1 1 2 2 2 2 Leucyl-tRNA synthetase, Domain 2 tRNA-synt_1e PF01406.19 ELR21946.1 - 0.0044 16.4 1.6 0.4 10.0 0.0 2.6 3 0 0 3 3 3 2 tRNA synthetases class I (C) catalytic domain Enkurin PF13864.6 ELR21946.1 - 0.016 15.6 4.5 6.8 7.2 0.5 3.7 3 0 0 3 3 3 0 Calmodulin-binding MAP65_ASE1 PF03999.12 ELR21946.1 - 0.04 12.6 1.5 1.5 7.4 0.1 2.2 2 0 0 2 2 2 0 Microtubule associated protein (MAP65/ASE1 family) DUF3450 PF11932.8 ELR21946.1 - 0.075 12.3 0.8 0.15 11.4 0.8 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) DivIC PF04977.15 ELR21946.1 - 0.12 12.2 0.3 0.37 10.6 0.3 1.9 1 0 0 1 1 1 0 Septum formation initiator UPF0242 PF06785.11 ELR21946.1 - 0.18 11.9 1.7 0.38 10.8 1.7 1.5 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus ABC_tran_CTD PF16326.5 ELR21946.1 - 0.29 11.4 4.8 1 9.6 4.8 2.0 1 0 0 1 1 1 0 ABC transporter C-terminal domain CLZ PF16526.5 ELR21946.1 - 1.9 8.9 5.0 2.4 8.6 0.7 3.3 4 0 0 4 4 4 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Prefoldin_2 PF01920.20 ELR21946.1 - 2.2 8.3 6.5 2.5 8.1 1.5 2.7 2 0 0 2 2 2 0 Prefoldin subunit YL1 PF05764.13 ELR21947.1 - 0.066 13.3 22.5 0.093 12.8 22.5 1.1 1 0 0 1 1 1 0 YL1 nuclear protein CD20 PF04103.15 ELR21947.1 - 0.64 10.1 3.2 15 5.6 3.2 2.8 1 1 0 1 1 1 0 CD20-like family GREB1 PF15782.5 ELR21947.1 - 2.7 5.0 17.6 3.2 4.7 17.6 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer TFIIF_alpha PF05793.12 ELR21947.1 - 3.7 6.0 29.1 4.8 5.7 29.1 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Macoilin PF09726.9 ELR21947.1 - 3.8 5.9 17.0 4.6 5.7 17.0 1.0 1 0 0 1 1 1 0 Macoilin family DUF4551 PF15087.6 ELR21947.1 - 9.2 5.0 13.1 10 4.8 13.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) Ribosomal_L30 PF00327.20 ELR21948.1 - 0.0076 16.1 0.0 0.013 15.3 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L30p/L7e Cons_hypoth95 PF03602.15 ELR21949.1 - 5.5e-06 26.1 0.0 3.3e-05 23.6 0.0 2.0 1 1 0 1 1 1 1 Conserved hypothetical protein 95 Tim17 PF02466.19 ELR21950.1 - 3.3e-23 82.2 7.4 4.8e-23 81.6 7.4 1.3 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family DUF4385 PF14328.6 ELR21951.1 - 1.1e-40 139.0 0.5 1.1e-40 139.0 0.5 1.7 2 1 0 2 2 2 1 Domain of unknown function (DUF4385) BTB PF00651.31 ELR21953.1 - 4.9e-22 78.3 0.0 4.8e-19 68.6 0.0 3.0 3 0 0 3 3 3 1 BTB/POZ domain BACK PF07707.15 ELR21953.1 - 9.8e-15 54.5 1.2 1.6e-14 53.8 0.6 1.7 2 0 0 2 2 2 1 BTB And C-terminal Kelch SPRY PF00622.28 ELR21953.1 - 5.8e-09 36.1 0.0 1.1e-08 35.2 0.0 1.4 1 0 0 1 1 1 1 SPRY domain Neuralized PF07177.12 ELR21953.1 - 0.0042 17.1 0.0 0.0075 16.3 0.0 1.5 1 0 0 1 1 1 1 Neuralized UBA_4 PF14555.6 ELR21953.1 - 0.0058 16.4 0.0 0.014 15.2 0.0 1.7 1 0 0 1 1 1 1 UBA-like domain PNISR PF15996.5 ELR21953.1 - 0.0083 16.4 1.5 0.013 15.7 1.5 1.3 1 0 0 1 1 1 1 Arginine/serine-rich protein PNISR Pox_Ag35 PF03286.14 ELR21953.1 - 0.042 13.6 2.0 0.073 12.9 2.0 1.3 1 0 0 1 1 1 0 Pox virus Ag35 surface protein Autophagy_N PF03986.13 ELR21953.1 - 0.097 12.6 1.3 0.19 11.7 1.3 1.4 1 0 0 1 1 1 0 Autophagocytosis associated protein (Atg3), N-terminal domain FYDLN_acid PF09538.10 ELR21953.1 - 0.86 10.3 7.8 2.1 9.0 7.8 1.6 1 0 0 1 1 1 0 Protein of unknown function (FYDLN_acid) DNA_pol_phi PF04931.13 ELR21953.1 - 1.5 6.8 7.1 2.4 6.2 7.1 1.2 1 0 0 1 1 1 0 DNA polymerase phi Aa_trans PF01490.18 ELR21954.1 - 1e-68 232.0 31.1 1.2e-68 231.7 31.1 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.13 ELR21954.1 - 1.4e-09 37.5 25.6 6e-09 35.4 25.6 2.0 1 1 0 1 1 1 1 Tryptophan/tyrosine permease family OTU PF02338.19 ELR21955.1 - 5.6e-06 26.9 0.0 8.3e-06 26.3 0.0 1.2 1 0 0 1 1 1 1 OTU-like cysteine protease Gpr1_Fun34_YaaH PF01184.19 ELR21956.1 - 2.8e-11 43.4 15.3 4.1e-11 42.9 15.3 1.2 1 0 0 1 1 1 1 GPR1/FUN34/yaaH family UPF0220 PF05255.11 ELR21956.1 - 0.062 12.9 0.2 0.062 12.9 0.2 1.8 2 1 0 2 2 2 0 Uncharacterised protein family (UPF0220) BTB PF00651.31 ELR21957.1 - 5.1e-12 46.0 0.1 1.3e-11 44.7 0.1 1.6 1 0 0 1 1 1 1 BTB/POZ domain eIF3_p135 PF12807.7 ELR21957.1 - 3.4e-06 27.2 0.0 1.7e-05 24.9 0.0 2.2 2 0 0 2 2 2 1 Translation initiation factor eIF3 subunit 135 CLU PF13236.6 ELR21957.1 - 0.00089 19.2 0.0 0.0016 18.3 0.0 1.4 1 0 0 1 1 1 1 Clustered mitochondria RNA_pol_3_Rpc31 PF11705.8 ELR21957.1 - 4.6 7.4 10.1 12 6.0 10.1 1.6 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 F5_F8_type_C PF00754.25 ELR21958.1 - 0.0086 16.2 2.7 4.2 7.5 0.1 3.0 2 1 0 2 2 2 2 F5/8 type C domain TIG_2 PF18020.1 ELR21958.1 - 0.14 12.8 0.1 8.7 7.0 0.0 2.7 2 0 0 2 2 2 0 TIG domain found in plexin RRN3 PF05327.11 ELR21960.1 - 0.0051 15.4 1.4 0.006 15.2 1.4 1.0 1 0 0 1 1 1 1 RNA polymerase I specific transcription initiation factor RRN3 DNA_pol_phi PF04931.13 ELR21960.1 - 0.011 13.9 9.6 0.013 13.7 9.6 1.0 1 0 0 1 1 1 0 DNA polymerase phi CobT PF06213.12 ELR21960.1 - 0.1 12.0 9.5 0.12 11.7 9.5 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Paf1 PF03985.13 ELR21960.1 - 0.22 10.5 10.9 0.23 10.4 10.9 1.1 1 0 0 1 1 1 0 Paf1 DUF4486 PF14858.6 ELR21960.1 - 0.26 9.7 1.5 0.32 9.4 1.5 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4486) Connexin PF00029.19 ELR21960.1 - 0.26 11.0 0.5 0.27 10.9 0.5 1.2 1 0 0 1 1 1 0 Connexin CDC45 PF02724.14 ELR21960.1 - 0.62 8.3 10.4 0.73 8.1 10.4 1.1 1 0 0 1 1 1 0 CDC45-like protein RPN2_C PF18004.1 ELR21960.1 - 0.69 9.8 8.3 0.8 9.6 8.3 1.1 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain GRP PF07172.11 ELR21960.1 - 2 9.2 12.0 3.1 8.5 12.0 1.3 1 0 0 1 1 1 0 Glycine rich protein family DUF3959 PF13105.6 ELR21960.1 - 4.5 6.7 4.9 5.5 6.4 4.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3959) TRAP_alpha PF03896.16 ELR21960.1 - 4.8 6.3 7.6 6.4 5.9 7.6 1.1 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Peptidase_C1 PF00112.23 ELR21963.1 - 3.2e-15 56.8 0.2 3.2e-13 50.3 0.0 2.2 2 0 0 2 2 2 2 Papain family cysteine protease Pkinase_Tyr PF07714.17 ELR21964.1 - 2.9e-45 154.6 0.0 4.8e-45 153.9 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ELR21964.1 - 5e-38 131.0 0.0 8.3e-38 130.3 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Ank_2 PF12796.7 ELR21964.1 - 1.2e-33 115.6 0.7 1.4e-17 64.1 0.1 3.5 2 1 1 3 3 3 2 Ankyrin repeats (3 copies) COR PF16095.5 ELR21964.1 - 1.3e-28 100.1 0.0 1.3e-17 64.2 0.0 2.3 2 0 0 2 2 2 2 C-terminal of Roc, COR, domain Ank_5 PF13857.6 ELR21964.1 - 2.6e-27 94.5 7.2 7.2e-09 35.7 0.1 5.2 2 2 3 5 5 5 4 Ankyrin repeats (many copies) Ras PF00071.22 ELR21964.1 - 7.6e-27 93.9 0.0 5.1e-14 52.2 0.0 2.3 2 0 0 2 2 2 2 Ras family Ank_4 PF13637.6 ELR21964.1 - 1.3e-26 92.6 5.4 7.5e-10 39.1 0.0 4.8 2 2 3 5 5 5 5 Ankyrin repeats (many copies) Ank PF00023.30 ELR21964.1 - 4.6e-25 86.9 7.3 2.4e-06 27.7 0.1 6.8 6 0 0 6 6 6 4 Ankyrin repeat Roc PF08477.13 ELR21964.1 - 2.8e-24 85.6 0.0 3e-21 75.8 0.0 3.1 2 1 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Ank_3 PF13606.6 ELR21964.1 - 1.1e-22 77.7 0.5 4.7e-05 23.5 0.0 6.9 6 0 0 6 6 6 3 Ankyrin repeat LRR_8 PF13855.6 ELR21964.1 - 1.3e-10 40.9 4.4 4e-09 36.1 1.7 2.4 1 1 1 2 2 2 2 Leucine rich repeat SH3_2 PF07653.17 ELR21964.1 - 1e-08 34.7 0.0 2e-08 33.8 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain LRR_4 PF12799.7 ELR21964.1 - 1.5e-08 34.8 4.3 0.0016 18.8 0.1 2.5 2 0 0 2 2 2 2 Leucine Rich repeats (2 copies) Arf PF00025.21 ELR21964.1 - 2.6e-05 23.8 0.0 8.5e-05 22.1 0.0 1.9 1 1 0 1 1 1 1 ADP-ribosylation factor family SH3_1 PF00018.28 ELR21964.1 - 2.9e-05 23.6 0.0 8.3e-05 22.1 0.0 1.8 1 0 0 1 1 1 1 SH3 domain ADH_zinc_N PF00107.26 ELR21964.1 - 0.00034 20.6 0.9 0.0016 18.4 0.2 2.6 2 1 0 2 2 2 1 Zinc-binding dehydrogenase PduV-EutP PF10662.9 ELR21964.1 - 0.002 17.9 0.0 2.1 8.1 0.0 2.4 2 0 0 2 2 2 2 Ethanolamine utilisation - propanediol utilisation Gtr1_RagA PF04670.12 ELR21964.1 - 0.0039 16.6 0.0 0.0076 15.6 0.0 1.4 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region LRR_1 PF00560.33 ELR21964.1 - 0.031 14.8 2.9 66 4.7 0.1 4.1 4 0 0 4 4 3 0 Leucine Rich Repeat SH3_9 PF14604.6 ELR21964.1 - 0.044 13.6 0.0 0.12 12.3 0.0 1.6 1 0 0 1 1 1 0 Variant SH3 domain DUF4821 PF16092.5 ELR21964.1 - 0.089 12.4 0.0 0.16 11.6 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4821) RsgA_GTPase PF03193.16 ELR21964.1 - 0.12 12.3 0.0 2.6 7.9 0.0 2.5 2 0 0 2 2 2 0 RsgA GTPase LRR_6 PF13516.6 ELR21964.1 - 4.9 7.5 6.1 1.2e+02 3.1 0.0 4.0 4 0 0 4 4 4 0 Leucine Rich repeat ATP-synt_ab PF00006.25 ELR21965.1 - 2.4e-54 184.2 0.1 2.1e-31 109.2 0.0 2.2 1 1 1 2 2 2 2 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_N PF02874.23 ELR21965.1 - 1.8e-13 50.8 0.9 3.7e-13 49.8 0.9 1.5 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain Nucleo_LEF-12 PF06256.11 ELR21965.1 - 0.033 14.0 0.1 0.51 10.1 0.0 2.2 2 0 0 2 2 2 0 Nucleopolyhedrovirus LEF-12 protein DUF4330 PF14221.6 ELR21966.1 - 0.062 13.5 2.0 0.11 12.7 1.9 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4330) PMP1_2 PF08114.11 ELR21966.1 - 0.064 13.0 0.3 0.11 12.3 0.3 1.4 1 0 0 1 1 1 0 ATPase proteolipid family MoaC PF01967.21 ELR21966.1 - 0.086 12.9 1.1 0.14 12.2 1.0 1.4 1 1 0 1 1 1 0 MoaC family Tad PF13400.6 ELR21966.1 - 0.22 11.8 5.9 0.33 11.3 5.9 1.3 1 0 0 1 1 1 0 Putative Flp pilus-assembly TadE/G-like Peptidase_C1 PF00112.23 ELR21967.1 - 5e-19 69.3 0.5 7.9e-19 68.6 0.5 1.3 1 0 0 1 1 1 1 Papain family cysteine protease QRPTase_C PF01729.19 ELR21970.1 - 3.4e-49 166.9 0.4 4.5e-47 160.0 0.4 2.1 1 1 0 1 1 1 1 Quinolinate phosphoribosyl transferase, C-terminal domain QRPTase_N PF02749.16 ELR21970.1 - 8.3e-21 73.8 0.0 2.2e-20 72.5 0.0 1.7 1 0 0 1 1 1 1 Quinolinate phosphoribosyl transferase, N-terminal domain TMP-TENI PF02581.17 ELR21970.1 - 0.013 14.8 0.0 0.02 14.2 0.0 1.3 1 0 0 1 1 1 0 Thiamine monophosphate synthase Alg6_Alg8 PF03155.15 ELR21971.1 - 0.001 18.1 1.3 0.0012 17.9 0.3 1.5 1 1 0 1 1 1 1 ALG6, ALG8 glycosyltransferase family DUF3488 PF11992.8 ELR21971.1 - 0.63 8.9 8.1 0.73 8.7 3.3 2.6 1 1 1 2 2 2 0 Domain of unknown function (DUF3488) AAA_33 PF13671.6 ELR21972.1 - 0.0051 17.0 0.0 0.05 13.8 0.0 2.3 1 1 0 1 1 1 1 AAA domain SBBP PF06739.11 ELR21972.1 - 0.036 14.1 2.2 0.089 12.8 0.6 2.3 2 0 0 2 2 2 0 Beta-propeller repeat CBS PF00571.28 ELR21973.1 - 3.9e-31 107.3 1.8 2.9e-07 30.8 0.0 4.3 4 0 0 4 4 4 4 CBS domain Tyr-DNA_phospho PF06087.12 ELR21974.1 - 8.6e-70 235.7 0.0 2.7e-65 220.9 0.0 2.9 1 1 1 2 2 2 2 Tyrosyl-DNA phosphodiesterase CUE PF02845.16 ELR21974.1 - 7.8e-07 28.7 0.0 1.5e-06 27.7 0.0 1.4 1 0 0 1 1 1 1 CUE domain UBA_4 PF14555.6 ELR21974.1 - 0.036 13.9 0.0 0.069 13.0 0.0 1.5 1 0 0 1 1 1 0 UBA-like domain BTB_2 PF02214.22 ELR21975.1 - 1.8e-16 60.3 0.1 7.2e-16 58.3 0.0 1.9 2 0 0 2 2 2 1 BTB/POZ domain BTB_3 PF16017.5 ELR21975.1 - 6.3e-05 23.0 0.0 0.00011 22.3 0.0 1.3 1 0 0 1 1 1 1 BTB/POZ domain BTB PF00651.31 ELR21975.1 - 0.0073 16.5 0.0 0.013 15.7 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain RRM_1 PF00076.22 ELR21976.1 - 3.6e-20 71.6 0.0 5.8e-20 70.9 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 ELR21976.1 - 0.0062 16.6 0.0 0.0088 16.1 0.0 1.2 1 0 0 1 1 1 1 RNA binding motif Limkain-b1 PF11608.8 ELR21976.1 - 0.077 13.1 0.1 0.12 12.5 0.1 1.3 1 0 0 1 1 1 0 Limkain b1 RRM_5 PF13893.6 ELR21976.1 - 0.089 12.4 0.0 0.14 11.7 0.0 1.2 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PAS PF00989.25 ELR21977.1 - 0.0019 18.2 0.0 0.0043 17.0 0.0 1.6 1 0 0 1 1 1 1 PAS fold TMF_TATA_bd PF12325.8 ELR21977.1 - 0.0022 18.2 3.2 0.028 14.7 3.5 2.0 2 0 0 2 2 2 1 TATA element modulatory factor 1 TATA binding Zn_clus PF00172.18 ELR21977.1 - 0.0048 17.0 9.3 0.0078 16.3 9.3 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain PAS_9 PF13426.7 ELR21977.1 - 0.028 14.7 0.0 0.07 13.4 0.0 1.6 1 0 0 1 1 1 0 PAS domain Tmemb_cc2 PF10267.9 ELR21977.1 - 0.028 13.6 0.3 0.04 13.1 0.3 1.2 1 0 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein DUF573 PF04504.14 ELR21977.1 - 0.043 14.5 1.1 0.043 14.5 1.1 1.8 2 0 0 2 2 1 0 Protein of unknown function, DUF573 BLOC1_2 PF10046.9 ELR21977.1 - 0.043 14.1 0.3 0.082 13.2 0.3 1.3 1 0 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 FTCD_C PF04961.12 ELR21977.1 - 0.069 12.9 0.5 0.12 12.1 0.5 1.4 1 0 0 1 1 1 0 Formiminotransferase-cyclodeaminase Nup54 PF13874.6 ELR21977.1 - 0.13 12.3 4.2 0.22 11.6 4.2 1.3 1 0 0 1 1 1 0 Nucleoporin complex subunit 54 PRP1_N PF06424.12 ELR21977.1 - 0.17 12.3 4.7 0.31 11.4 4.7 1.4 1 0 0 1 1 1 0 PRP1 splicing factor, N-terminal Sigma70_ner PF04546.13 ELR21977.1 - 0.21 11.4 3.2 0.37 10.6 3.2 1.3 1 0 0 1 1 1 0 Sigma-70, non-essential region AT_hook PF02178.19 ELR21977.1 - 0.29 11.1 5.1 1.3 9.2 5.1 2.1 1 0 0 1 1 1 0 AT hook motif SR-25 PF10500.9 ELR21977.1 - 0.32 10.6 8.9 1.4 8.4 2.0 2.2 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein MAGE_N PF12440.8 ELR21977.1 - 0.57 10.9 4.8 0.63 10.7 1.5 2.4 2 0 0 2 2 2 0 Melanoma associated antigen family N terminal CDC45 PF02724.14 ELR21977.1 - 5.1 5.3 9.8 7.7 4.7 9.8 1.1 1 0 0 1 1 1 0 CDC45-like protein Usp PF00582.26 ELR21978.1 - 3.5e-25 89.2 3.4 4.6e-25 88.8 3.4 1.2 1 0 0 1 1 1 1 Universal stress protein family F_actin_bund_C PF18060.1 ELR21979.1 - 5.4e-19 68.1 10.2 5.4e-19 68.1 10.2 1.7 2 0 0 2 2 2 1 F actin bundling C terminal SIKE PF05769.11 ELR21979.1 - 0.021 14.8 1.3 0.034 14.1 1.3 1.6 1 0 0 1 1 1 0 SIKE family Gon7 PF08738.10 ELR21979.1 - 0.04 14.0 0.3 1.1 9.4 0.2 2.6 2 1 1 3 3 3 0 Gon7 family ABC_tran_CTD PF16326.5 ELR21979.1 - 0.044 14.0 6.3 0.11 12.8 6.3 1.7 1 0 0 1 1 1 0 ABC transporter C-terminal domain SYCE1 PF15233.6 ELR21979.1 - 0.057 13.5 3.8 0.063 13.3 1.8 2.1 1 1 0 2 2 2 0 Synaptonemal complex central element protein 1 tRNA-synt_His PF13393.6 ELR21979.1 - 0.1 11.8 5.0 0.18 11.0 5.0 1.4 1 0 0 1 1 1 0 Histidyl-tRNA synthetase PEP-utilisers_N PF05524.13 ELR21979.1 - 1.3 9.2 9.6 3 8.0 9.6 1.6 1 1 0 1 1 1 0 PEP-utilising enzyme, N-terminal APG6_N PF17675.1 ELR21979.1 - 3.9 8.0 8.5 8.8 6.9 8.5 1.8 1 1 0 1 1 1 0 Apg6 coiled-coil region Seryl_tRNA_N PF02403.22 ELR21979.1 - 8 6.8 8.9 38 4.6 0.3 3.0 2 1 1 3 3 3 0 Seryl-tRNA synthetase N-terminal domain TRADD_N PF09034.10 ELR21980.1 - 0.05 13.6 0.0 0.077 13.0 0.0 1.3 1 0 0 1 1 1 0 TRADD, N-terminal domain RCC1 PF00415.18 ELR21981.1 - 4.3e-85 280.2 15.2 4.2e-15 56.1 0.0 7.4 7 1 0 7 7 7 7 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 ELR21981.1 - 1.7e-41 139.2 41.9 1.1e-06 28.3 0.3 8.8 10 0 0 10 10 10 8 Regulator of chromosome condensation (RCC1) repeat DUF4213 PF13938.6 ELR21981.1 - 2.1e-07 31.1 1.3 3.1 8.1 0.0 5.2 3 1 2 5 5 5 3 Putative heavy-metal chelation Peptidase_C25_C PF03785.14 ELR21981.1 - 0.13 12.1 3.0 0.18 11.6 0.0 2.8 4 0 0 4 4 4 0 Peptidase family C25, C terminal ig-like domain PapC_C PF13953.6 ELR21981.1 - 0.25 11.2 0.9 11 5.9 0.1 2.8 2 0 0 2 2 2 0 PapC C-terminal domain Kelch_4 PF13418.6 ELR21981.1 - 2.1 8.4 13.4 12 6.0 0.1 5.1 5 0 0 5 5 5 0 Galactose oxidase, central domain Tubulin PF00091.25 ELR21982.1 - 3.3e-29 102.5 0.0 4.7e-29 102.0 0.0 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_3 PF14881.6 ELR21982.1 - 7.1e-06 25.8 0.0 1.4e-05 24.9 0.0 1.4 1 0 0 1 1 1 1 Tubulin domain F-box-like PF12937.7 ELR21982.1 - 8.2e-05 22.4 0.4 8.2e-05 22.4 0.4 2.1 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 ELR21982.1 - 0.00055 19.7 0.1 0.0013 18.5 0.1 1.6 1 0 0 1 1 1 1 F-box domain DUF5074 PF16819.5 ELR21983.1 - 0.089 12.8 0.0 0.2 11.7 0.0 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF5074) Zip PF02535.22 ELR21984.1 - 9.2e-67 225.6 12.7 8.2e-66 222.5 12.7 1.9 1 1 0 1 1 1 1 ZIP Zinc transporter DUF1772 PF08592.11 ELR21984.1 - 0.06 13.7 0.3 0.4 11.0 0.0 2.5 2 2 0 2 2 2 0 Domain of unknown function (DUF1772) Peptidase_U4 PF03419.13 ELR21984.1 - 0.12 11.6 2.8 5.1 6.3 0.1 2.3 2 0 0 2 2 2 0 Sporulation factor SpoIIGA PrgI PF12666.7 ELR21984.1 - 7.6 7.3 10.9 2.6 8.8 0.9 3.8 3 1 1 4 4 4 0 PrgI family protein zf-ribbon_3 PF13248.6 ELR21985.1 - 0.00086 18.6 0.7 1.2 8.7 0.1 2.4 2 0 0 2 2 2 2 zinc-ribbon domain zinc_ribbon_2 PF13240.6 ELR21985.1 - 0.006 16.3 1.0 0.72 9.7 0.1 2.3 2 0 0 2 2 2 2 zinc-ribbon domain DZR PF12773.7 ELR21985.1 - 0.01 15.8 0.2 2.1 8.4 0.1 2.3 2 0 0 2 2 2 0 Double zinc ribbon GFA PF04828.14 ELR21985.1 - 0.087 13.2 0.0 9.9 6.6 0.0 2.3 2 0 0 2 2 2 0 Glutathione-dependent formaldehyde-activating enzyme NOB1_Zn_bind PF08772.11 ELR21985.1 - 0.16 12.1 0.3 7.1 6.9 0.1 2.2 2 0 0 2 2 2 0 Nin one binding (NOB1) Zn-ribbon like Zn-ribbon_8 PF09723.10 ELR21985.1 - 0.65 10.2 2.2 5.8 7.1 0.1 2.2 2 0 0 2 2 2 0 Zinc ribbon domain Nudix_N_2 PF14803.6 ELR21985.1 - 1.2 9.2 5.2 1.8 8.5 0.8 2.3 2 0 0 2 2 2 0 Nudix N-terminal zf-NADH-PPase PF09297.11 ELR21985.1 - 6 6.6 8.2 6.8 6.4 2.5 2.4 2 0 0 2 2 2 0 NADH pyrophosphatase zinc ribbon domain GHMP_kinases_N PF00288.26 ELR21986.1 - 3.4e-14 52.8 5.9 5e-14 52.3 2.4 2.6 2 0 0 2 2 2 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.13 ELR21986.1 - 0.0007 19.9 0.5 0.0018 18.6 0.5 1.6 1 0 0 1 1 1 1 GHMP kinases C terminal His_Phos_1 PF00300.22 ELR21987.1 - 7e-24 84.6 2.7 7.2e-12 45.4 1.1 3.7 1 1 1 2 2 2 2 Histidine phosphatase superfamily (branch 1) Pkinase_Tyr PF07714.17 ELR21988.1 - 6.2e-52 176.4 0.0 9.6e-52 175.8 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ELR21988.1 - 9.1e-43 146.5 0.0 8.3e-29 100.7 0.0 2.3 2 0 0 2 2 2 2 Protein kinase domain COR PF16095.5 ELR21988.1 - 2.7e-29 102.4 0.1 7.3e-29 101.0 0.1 1.7 1 0 0 1 1 1 1 C-terminal of Roc, COR, domain Roc PF08477.13 ELR21988.1 - 2.2e-17 63.4 0.1 8.5e-13 48.6 0.0 2.5 1 1 1 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 ELR21988.1 - 7.1e-08 32.2 0.0 2.4e-05 24.0 0.0 2.3 2 0 0 2 2 2 2 Ras family Arf PF00025.21 ELR21988.1 - 3.5e-05 23.3 0.1 0.0011 18.4 0.0 2.3 2 0 0 2 2 2 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 ELR21988.1 - 0.02 15.0 0.0 0.051 13.7 0.0 1.8 1 0 0 1 1 1 0 50S ribosome-binding GTPase SH3_1 PF00018.28 ELR21988.1 - 0.054 13.1 0.0 0.13 11.9 0.0 1.7 1 0 0 1 1 1 0 SH3 domain Kinase-like PF14531.6 ELR21988.1 - 0.14 11.5 0.0 0.62 9.3 0.0 1.9 2 0 0 2 2 2 0 Kinase-like Pkinase_Tyr PF07714.17 ELR21989.1 - 3.5e-39 134.6 0.0 4.9e-39 134.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ELR21989.1 - 4.1e-35 121.4 0.0 2.2e-22 79.7 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain COR PF16095.5 ELR21989.1 - 5.4e-28 98.1 0.0 9.2e-28 97.4 0.0 1.3 1 0 0 1 1 1 1 C-terminal of Roc, COR, domain Roc PF08477.13 ELR21989.1 - 1.5e-17 63.9 0.3 4.1e-15 56.1 0.3 2.4 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 ELR21989.1 - 2.2e-07 30.6 0.1 6.1e-05 22.7 0.0 2.3 2 0 0 2 2 2 2 Ras family Arf PF00025.21 ELR21989.1 - 3.5e-07 29.8 0.2 0.00012 21.5 0.0 2.2 2 0 0 2 2 2 2 ADP-ribosylation factor family LRR_8 PF13855.6 ELR21989.1 - 1.1e-05 25.1 0.0 2.6e-05 23.9 0.0 1.7 1 0 0 1 1 1 1 Leucine rich repeat SH3_2 PF07653.17 ELR21989.1 - 6.1e-05 22.6 0.1 0.00015 21.4 0.1 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.6 ELR21989.1 - 0.00013 21.8 0.0 0.00031 20.6 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain LRR_4 PF12799.7 ELR21989.1 - 0.00039 20.8 0.0 0.0012 19.2 0.0 1.9 1 0 0 1 1 1 1 Leucine Rich repeats (2 copies) AAA_15 PF13175.6 ELR21989.1 - 0.00063 19.6 0.0 0.0011 18.8 0.0 1.2 1 0 0 1 1 1 1 AAA ATPase domain GTP_EFTU PF00009.27 ELR21989.1 - 0.0031 17.1 0.1 0.017 14.7 0.1 2.0 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain LRR_1 PF00560.33 ELR21989.1 - 0.054 14.0 0.1 30 5.7 0.0 3.1 2 0 0 2 2 2 0 Leucine Rich Repeat APH PF01636.23 ELR21989.1 - 0.065 13.2 0.2 0.46 10.4 0.1 2.2 2 0 0 2 2 2 0 Phosphotransferase enzyme family MMR_HSR1 PF01926.23 ELR21989.1 - 0.13 12.4 0.0 0.27 11.3 0.0 1.6 1 0 0 1 1 1 0 50S ribosome-binding GTPase G-alpha PF00503.20 ELR21989.1 - 0.2 10.8 0.0 0.3 10.2 0.0 1.3 1 0 0 1 1 1 0 G-protein alpha subunit PPR_2 PF13041.6 ELR21990.1 - 3.8e-34 116.6 0.4 1.1e-08 35.2 0.1 8.6 3 1 6 9 9 9 6 PPR repeat family PPR PF01535.20 ELR21990.1 - 1.4e-26 90.8 1.3 3.1e-05 23.9 0.0 8.2 9 0 0 9 9 8 5 PPR repeat PPR_3 PF13812.6 ELR21990.1 - 1.2e-24 86.1 0.8 1.7e-06 28.0 0.0 4.8 3 1 2 5 5 5 4 Pentatricopeptide repeat domain PPR_1 PF12854.7 ELR21990.1 - 7.2e-23 80.0 0.0 0.00011 21.8 0.0 6.5 6 0 0 6 6 6 5 PPR repeat PPR_long PF17177.4 ELR21990.1 - 3.6e-21 75.5 0.3 5.3e-11 42.3 0.0 2.8 2 1 1 3 3 3 2 Pentacotripeptide-repeat region of PRORP TPR_16 PF13432.6 ELR21990.1 - 6e-05 23.6 0.5 6e-05 23.6 0.5 4.5 5 1 1 6 6 4 1 Tetratricopeptide repeat TPR_19 PF14559.6 ELR21990.1 - 6e-05 23.5 7.4 0.023 15.2 0.1 5.3 4 1 2 6 6 6 2 Tetratricopeptide repeat BTAD PF03704.17 ELR21990.1 - 7.1e-05 23.3 1.4 0.79 10.1 0.0 3.4 1 1 2 3 3 3 2 Bacterial transcriptional activator domain Ank_5 PF13857.6 ELR21990.1 - 0.00049 20.3 0.0 0.087 13.2 0.0 3.6 3 1 1 4 4 3 1 Ankyrin repeats (many copies) TPR_4 PF07721.14 ELR21990.1 - 0.00058 20.2 2.0 19 6.3 0.0 5.2 4 0 0 4 4 4 0 Tetratricopeptide repeat Mo25 PF08569.11 ELR21990.1 - 0.0014 18.1 0.1 0.0021 17.5 0.1 1.2 1 0 0 1 1 1 1 Mo25-like Clathrin PF00637.20 ELR21990.1 - 0.0017 18.3 1.4 0.58 10.0 0.0 4.0 3 1 1 4 4 4 1 Region in Clathrin and VPS TPR_14 PF13428.6 ELR21990.1 - 0.004 17.8 22.7 7.7 7.6 0.4 7.7 7 1 2 9 9 8 1 Tetratricopeptide repeat MRP-S27 PF10037.9 ELR21990.1 - 0.012 14.6 0.2 0.14 11.0 0.0 2.5 2 1 1 3 3 3 0 Mitochondrial 28S ribosomal protein S27 ATP13 PF12921.7 ELR21990.1 - 0.015 15.1 0.0 0.28 11.1 0.0 3.0 1 1 1 3 3 3 0 Mitochondrial ATPase expression AEP1 PF17049.5 ELR21990.1 - 0.087 11.9 0.1 0.14 11.3 0.1 1.2 1 0 0 1 1 1 0 ATPase expression protein 1 Ovate PF04844.13 ELR21990.1 - 0.1 12.6 1.2 0.22 11.6 0.1 2.1 2 0 0 2 2 2 0 Transcriptional repressor, ovate DUF3368 PF11848.8 ELR21990.1 - 0.15 11.9 0.3 69 3.3 0.0 4.3 4 0 0 4 4 4 0 Domain of unknown function (DUF3368) ECSIT PF06239.11 ELR21990.1 - 0.15 11.2 0.2 2.3 7.3 0.1 2.7 2 1 1 3 3 3 0 Evolutionarily conserved signalling intermediate in Toll pathway TPR_6 PF13174.6 ELR21990.1 - 1.2 9.9 7.8 28 5.6 0.1 5.2 5 1 1 6 6 5 0 Tetratricopeptide repeat Kelch_3 PF13415.6 ELR21991.1 - 3.2e-36 122.9 3.6 3.8e-07 30.2 0.0 5.8 5 0 0 5 5 5 5 Galactose oxidase, central domain Kelch_1 PF01344.25 ELR21991.1 - 3.8e-34 116.0 11.4 5.4e-09 35.5 0.2 5.3 5 0 0 5 5 5 5 Kelch motif Kelch_6 PF13964.6 ELR21991.1 - 2.1e-29 100.8 9.5 1e-06 28.8 0.1 5.3 3 2 2 5 5 5 5 Kelch motif Kelch_4 PF13418.6 ELR21991.1 - 1.8e-28 98.3 14.2 9.1e-08 32.0 0.1 5.7 4 1 2 6 6 6 5 Galactose oxidase, central domain Kelch_5 PF13854.6 ELR21991.1 - 9.8e-28 95.7 12.8 1.3e-06 28.2 0.2 5.4 5 0 0 5 5 5 5 Kelch motif Kelch_2 PF07646.15 ELR21991.1 - 2.2e-22 78.1 10.7 1.8e-05 24.5 0.1 5.4 5 0 0 5 5 5 5 Kelch motif HMMR_N PF15905.5 ELR21991.1 - 0.0007 19.2 4.1 0.0007 19.2 4.1 2.2 2 0 0 2 2 2 1 Hyaluronan mediated motility receptor N-terminal Fez1 PF06818.15 ELR21991.1 - 0.82 10.1 25.1 0.054 13.9 6.8 2.2 2 0 0 2 2 2 0 Fez1 SlyX PF04102.12 ELR21991.1 - 4.4 8.0 11.2 2.7 8.7 0.9 3.4 2 1 1 3 3 3 0 SlyX Macoilin PF09726.9 ELR21991.1 - 8 4.9 26.5 13 4.2 26.5 1.2 1 0 0 1 1 1 0 Macoilin family VDE PF07137.11 ELR21992.1 - 2.7e-09 36.9 6.8 2.7e-09 36.9 6.8 1.6 2 0 0 2 2 2 1 VDE lipocalin domain VDE PF07137.11 ELR21994.1 - 1.2e-05 24.9 11.4 1.2e-05 24.9 11.4 1.6 1 1 1 2 2 2 1 VDE lipocalin domain Pkinase_Tyr PF07714.17 ELR21995.1 - 9.9e-23 80.7 0.0 1.1e-22 80.5 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ELR21995.1 - 2e-15 56.9 0.0 2.4e-15 56.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Zip PF02535.22 ELR21998.1 - 2.4e-28 99.3 11.9 9e-25 87.6 4.0 2.1 1 1 1 2 2 2 2 ZIP Zinc transporter DUF4407 PF14362.6 ELR21998.1 - 0.36 10.1 3.3 0.66 9.3 3.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Wzy_C PF04932.15 ELR21998.1 - 0.66 9.6 9.2 0.48 10.1 0.0 2.5 2 1 0 2 2 2 0 O-Antigen ligase DUF4191 PF13829.6 ELR21998.1 - 4.5 6.6 7.6 0.67 9.3 1.6 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4191) APG17 PF04108.12 ELR21999.1 - 4.4e-38 131.4 19.2 6.3e-38 130.9 19.2 1.1 1 0 0 1 1 1 1 Autophagy protein Apg17 DUF2125 PF09898.9 ELR21999.1 - 0.0089 15.7 1.1 0.018 14.7 0.8 1.7 1 1 1 2 2 2 1 Uncharacterized protein conserved in bacteria (DUF2125) Dynein_C PF18199.1 ELR21999.1 - 0.028 13.6 1.5 0.071 12.3 1.5 1.6 1 0 0 1 1 1 0 Dynein heavy chain C-terminal domain DUF1664 PF07889.12 ELR21999.1 - 0.03 14.4 10.1 1.7 8.7 0.6 3.5 3 0 0 3 3 3 0 Protein of unknown function (DUF1664) DUF948 PF06103.11 ELR21999.1 - 0.046 14.0 8.1 0.51 10.6 0.4 3.8 3 1 0 3 3 3 0 Bacterial protein of unknown function (DUF948) Phage_ABA_S PF18066.1 ELR21999.1 - 0.15 12.7 0.0 23 5.8 0.0 2.5 2 0 0 2 2 2 0 Phage ABA sandwich domain YkyA PF10368.9 ELR21999.1 - 0.25 11.0 20.7 0.099 12.3 2.8 3.5 2 2 1 3 3 3 0 Putative cell-wall binding lipoprotein Goodbye PF17109.5 ELR21999.1 - 0.49 10.8 4.2 3.2 8.2 0.0 3.5 3 1 1 4 4 4 0 fungal STAND N-terminal Goodbye domain ALIX_LYPXL_bnd PF13949.6 ELR21999.1 - 1.4 8.2 26.4 14 4.8 26.4 2.2 1 1 0 1 1 1 0 ALIX V-shaped domain binding to HIV GARP PF16731.5 ELR21999.1 - 2.5 7.8 7.9 2.1 8.0 0.5 3.1 3 0 0 3 3 3 0 Glutamic acid/alanine-rich protein of Trypanosoma DUF4795 PF16043.5 ELR21999.1 - 2.9 7.5 13.9 7.3 6.1 8.7 3.1 1 1 0 2 2 2 0 Domain of unknown function (DUF4795) Fib_alpha PF08702.10 ELR21999.1 - 3.6 7.8 17.2 1.9 8.7 6.0 3.4 3 1 1 4 4 4 0 Fibrinogen alpha/beta chain family BLOC1_2 PF10046.9 ELR21999.1 - 3.9 7.8 12.4 24 5.3 0.1 4.3 3 1 1 4 4 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Baculo_PEP_C PF04513.12 ELR21999.1 - 5.3 7.1 9.5 4.1 7.4 1.2 3.1 2 1 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF4446 PF14584.6 ELR21999.1 - 5.9 6.9 9.5 19 5.2 0.5 3.7 4 1 0 4 4 4 0 Protein of unknown function (DUF4446) Pro-kuma_activ PF09286.11 ELR22000.1 - 7.3e-12 45.8 0.1 7.2e-11 42.6 0.0 2.3 2 0 0 2 2 2 1 Pro-kumamolisin, activation domain TruD PF01142.18 ELR22003.1 - 4.7e-77 259.6 0.0 1.3e-75 254.8 0.0 2.7 2 1 0 2 2 2 1 tRNA pseudouridine synthase D (TruD) GRP PF07172.11 ELR22003.1 - 0.09 13.5 10.0 0.09 13.5 7.9 2.1 2 0 0 2 2 2 0 Glycine rich protein family Med9 PF07544.13 ELR22004.1 - 0.049 13.7 23.3 1.2 9.3 1.0 4.2 2 2 1 3 3 3 0 RNA polymerase II transcription mediator complex subunit 9 Filament PF00038.21 ELR22004.1 - 0.073 12.7 44.7 0.084 12.4 10.0 3.9 2 1 2 4 4 4 0 Intermediate filament protein DUF5357 PF17310.2 ELR22004.1 - 0.62 8.6 4.0 0.92 8.0 3.2 1.4 1 1 0 1 1 1 0 Family of unknown function (DUF5357) DUF4435 PF14491.6 ELR22004.1 - 1.7 8.5 6.4 0.12 12.2 0.7 2.0 2 1 0 2 2 2 0 Protein of unknown function (DUF4435) ubiquitin PF00240.23 ELR22004.1 - 3.5 7.5 5.1 1.4 8.7 0.2 2.6 3 0 0 3 3 3 0 Ubiquitin family DEAD PF00270.29 ELR22005.1 - 3e-50 170.4 0.0 8.2e-50 169.0 0.0 1.8 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ELR22005.1 - 1.5e-28 99.3 5.8 5.1e-28 97.6 0.0 3.3 3 1 1 4 4 4 1 Helicase conserved C-terminal domain ERCC3_RAD25_C PF16203.5 ELR22005.1 - 0.013 14.7 0.0 0.013 14.7 0.0 2.3 2 0 0 2 2 2 0 ERCC3/RAD25/XPB C-terminal helicase CMS1 PF14617.6 ELR22005.1 - 0.016 14.6 0.0 0.016 14.6 0.0 4.2 3 1 1 4 4 4 0 U3-containing 90S pre-ribosomal complex subunit AAA_22 PF13401.6 ELR22005.1 - 0.33 11.2 2.8 0.68 10.2 0.3 2.8 2 1 1 3 3 3 0 AAA domain Sporozoite_P67 PF05642.11 ELR22005.1 - 0.55 8.2 10.8 0.76 7.8 10.8 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen TAF4 PF05236.14 ELR22005.1 - 1.4 8.6 25.9 3.1 7.5 25.9 1.6 1 0 0 1 1 1 0 Transcription initiation factor TFIID component TAF4 family SYF2 PF08231.12 ELR22006.1 - 2e-37 129.1 20.1 2e-37 129.1 20.1 2.3 2 0 0 2 2 2 1 SYF2 splicing factor Ank_2 PF12796.7 ELR22007.1 - 6.1e-15 55.6 0.8 6e-09 36.4 0.5 4.3 2 2 1 4 4 4 3 Ankyrin repeats (3 copies) Ank_3 PF13606.6 ELR22007.1 - 7.1e-15 53.6 7.4 0.19 12.4 0.1 8.4 9 0 0 9 9 9 4 Ankyrin repeat Ank_4 PF13637.6 ELR22007.1 - 1.4e-13 51.1 3.1 0.11 13.2 0.1 6.4 2 2 5 7 7 7 5 Ankyrin repeats (many copies) Ank PF00023.30 ELR22007.1 - 4.7e-13 48.9 7.8 0.051 14.1 0.3 7.5 7 2 0 7 7 7 4 Ankyrin repeat Ank_5 PF13857.6 ELR22007.1 - 3.9e-11 43.0 4.3 0.0035 17.6 0.0 5.6 5 1 2 7 7 7 3 Ankyrin repeats (many copies) DUF3982 PF13138.6 ELR22007.1 - 0.49 10.3 1.9 25 4.8 0.0 3.7 5 0 0 5 5 5 0 Protein of unknown function (DUF3982) Topoisom_I_N PF02919.15 ELR22008.1 - 1.6e-58 197.8 0.0 2e-35 122.3 0.0 2.2 1 1 1 2 2 2 2 Eukaryotic DNA topoisomerase I, DNA binding fragment Topoisom_I PF01028.20 ELR22008.1 - 1.7e-52 178.0 0.0 2.4e-52 177.5 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic DNA topoisomerase I, catalytic core Topo_C_assoc PF14370.6 ELR22008.1 - 5.2e-06 26.3 0.1 1.6e-05 24.7 0.1 1.9 1 1 0 1 1 1 1 C-terminal topoisomerase domain HEAT PF02985.22 ELR22009.1 - 0.00094 19.2 5.3 0.083 13.2 0.0 4.3 4 0 0 4 4 4 1 HEAT repeat HEAT_2 PF13646.6 ELR22009.1 - 0.012 16.0 6.0 0.29 11.5 4.5 3.3 2 1 0 2 2 2 0 HEAT repeats HEAT_EZ PF13513.6 ELR22009.1 - 6.9 7.3 13.4 1.2 9.7 0.1 5.4 6 1 1 7 7 7 0 HEAT-like repeat ADK PF00406.22 ELR22011.1 - 6.6e-43 146.4 0.0 9.3e-43 145.9 0.0 1.1 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 ELR22011.1 - 7e-20 71.8 0.0 1.3e-19 71.0 0.0 1.4 1 0 0 1 1 1 1 AAA domain ADK_lid PF05191.14 ELR22011.1 - 6.2e-16 58.1 0.0 1.1e-15 57.4 0.0 1.4 1 0 0 1 1 1 1 Adenylate kinase, active site lid Miga PF10265.9 ELR22012.1 - 0.65 8.9 2.2 0.97 8.3 2.2 1.2 1 0 0 1 1 1 0 Mitoguardin GATA PF00320.27 ELR22013.1 - 2.3e-13 49.5 3.6 9.3e-13 47.6 3.6 2.1 1 0 0 1 1 1 1 GATA zinc finger FYVE PF01363.21 ELR22013.1 - 0.035 14.3 1.8 5.2 7.3 0.1 2.4 2 0 0 2 2 2 0 FYVE zinc finger Actino_peptide PF14408.6 ELR22013.1 - 0.43 10.7 0.1 0.43 10.7 0.1 3.6 3 0 0 3 3 3 0 Ribosomally synthesised peptide in actinomycetes CH PF00307.31 ELR22014.1 - 7.1e-36 122.7 0.0 4e-22 78.5 0.0 2.1 2 0 0 2 2 2 2 Calponin homology (CH) domain CAMSAP_CH PF11971.8 ELR22014.1 - 5.2e-09 35.8 0.0 0.00012 21.9 0.0 2.3 2 0 0 2 2 2 2 CAMSAP CH domain Filamin PF00630.19 ELR22014.1 - 0.014 16.2 0.0 0.024 15.4 0.0 1.4 1 0 0 1 1 1 0 Filamin/ABP280 repeat Peptidase_S15 PF02129.18 ELR22014.1 - 0.099 12.2 0.2 0.15 11.6 0.2 1.2 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) Ras PF00071.22 ELR22016.1 - 6.7e-57 191.6 0.0 7.7e-57 191.4 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR22016.1 - 2.6e-19 69.6 0.0 3.5e-19 69.2 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR22016.1 - 3.7e-08 33.0 0.0 4.2e-08 32.8 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 ELR22016.1 - 1.5e-05 24.6 0.1 4.6e-05 23.0 0.1 1.8 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 ELR22016.1 - 0.00022 21.3 0.0 0.0003 20.9 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase ATP_bind_1 PF03029.17 ELR22016.1 - 0.019 14.8 0.3 0.15 11.8 0.0 2.0 1 1 1 2 2 2 0 Conserved hypothetical ATP binding protein Septin PF00735.18 ELR22016.1 - 0.12 11.6 0.0 0.18 11.1 0.0 1.3 1 0 0 1 1 1 0 Septin Acetyltransf_1 PF00583.25 ELR22017.1 - 1.4e-12 47.9 0.0 2.5e-12 47.1 0.0 1.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 ELR22017.1 - 4.4e-09 36.4 0.0 7.8e-09 35.6 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 ELR22017.1 - 1.7e-06 28.3 0.0 2.9e-06 27.6 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 ELR22017.1 - 5.3e-05 23.1 0.0 0.00013 21.9 0.0 1.7 2 0 0 2 2 2 1 FR47-like protein Acetyltransf_3 PF13302.7 ELR22017.1 - 0.0007 20.3 0.2 0.0012 19.5 0.2 1.7 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 ELR22017.1 - 0.028 14.5 0.0 0.048 13.7 0.0 1.5 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 ELR22017.1 - 0.12 12.5 0.0 0.26 11.5 0.0 1.5 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase Ras PF00071.22 ELR22018.1 - 3.7e-40 137.2 0.0 5.3e-40 136.7 0.0 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR22018.1 - 3.1e-10 40.3 0.0 6.2e-10 39.3 0.0 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR22018.1 - 0.00019 20.9 0.0 0.00027 20.5 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family F-box-like PF12937.7 ELR22018.1 - 0.028 14.3 0.2 0.059 13.3 0.2 1.6 1 0 0 1 1 1 0 F-box-like dCMP_cyt_deam_1 PF00383.23 ELR22019.1 - 5.1e-14 52.0 0.0 3.8e-13 49.2 0.0 1.9 2 0 0 2 2 2 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 ELR22019.1 - 8.8e-13 48.2 0.0 1.1e-12 47.9 0.0 1.3 1 0 0 1 1 1 1 MafB19-like deaminase SNAD4 PF18750.1 ELR22019.1 - 0.00018 21.6 0.0 0.00067 19.8 0.0 1.7 2 0 0 2 2 2 1 Secreted Novel AID/APOBEC-like Deaminase 4 NAD1 PF18778.1 ELR22019.1 - 0.0094 16.1 0.1 0.02 15.0 0.0 1.5 2 0 0 2 2 2 1 Novel AID APOBEC clade 1 APOBEC_N PF08210.11 ELR22019.1 - 0.043 13.7 0.0 0.049 13.5 0.0 1.2 1 0 0 1 1 1 0 APOBEC-like N-terminal domain Bd3614-deam PF14439.6 ELR22019.1 - 0.092 12.8 1.0 0.82 9.7 0.4 2.1 1 1 1 2 2 2 0 Bd3614-like deaminase APOBEC2 PF18772.1 ELR22019.1 - 0.098 12.7 0.0 0.18 11.9 0.0 1.4 1 0 0 1 1 1 0 APOBEC2 APOBEC4 PF18775.1 ELR22019.1 - 0.16 12.1 0.3 2.5 8.3 0.4 2.1 2 0 0 2 2 2 0 APOBEC4 APOBEC3 PF18771.1 ELR22019.1 - 0.2 11.8 0.0 0.38 10.9 0.0 1.4 2 0 0 2 2 2 0 APOBEC3 Reprolysin_3 PF13582.6 ELR22020.1 - 2.6e-13 50.6 0.0 4.4e-13 49.8 0.0 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_5 PF13688.6 ELR22020.1 - 2.7e-13 50.5 0.0 4.2e-13 49.9 0.0 1.2 1 0 0 1 1 1 1 Metallo-peptidase family M12 CBM49 PF09478.10 ELR22020.1 - 2.8e-07 30.8 0.0 5.1e-07 29.9 0.0 1.4 1 0 0 1 1 1 1 Carbohydrate binding domain CBM49 Reprolysin_2 PF13574.6 ELR22020.1 - 1.6e-06 28.1 0.0 2.8e-06 27.4 0.0 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.6 ELR22020.1 - 1.3e-05 25.0 0.0 2e-05 24.4 0.0 1.2 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like CBM_2 PF00553.19 ELR22020.1 - 0.0088 16.3 0.7 0.018 15.3 0.7 1.5 1 0 0 1 1 1 1 Cellulose binding domain Reprolysin PF01421.19 ELR22020.1 - 0.0093 15.9 0.0 0.014 15.3 0.0 1.2 1 0 0 1 1 1 1 Reprolysin (M12B) family zinc metalloprotease Pro-kuma_activ PF09286.11 ELR22022.1 - 2.8e-29 102.2 0.0 8.6e-29 100.7 0.0 1.8 3 0 0 3 3 3 1 Pro-kumamolisin, activation domain Peptidase_S8 PF00082.22 ELR22022.1 - 0.0087 15.3 0.3 0.022 14.0 0.0 1.8 2 0 0 2 2 2 1 Subtilase family F-actin_cap_A PF01267.17 ELR22022.1 - 0.087 12.2 0.1 0.15 11.4 0.1 1.3 1 0 0 1 1 1 0 F-actin capping protein alpha subunit HAD_2 PF13419.6 ELR22023.1 - 4e-16 59.6 0.1 1.5e-14 54.5 0.0 2.1 2 0 0 2 2 2 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 ELR22023.1 - 5.5e-08 33.3 0.1 0.00016 22.0 0.0 2.1 1 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase HAD PF12710.7 ELR22023.1 - 8.5e-07 29.6 0.9 1.3e-05 25.6 0.9 2.3 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 ELR22023.1 - 1.1e-06 28.6 0.0 2e-06 27.8 0.0 1.5 1 0 0 1 1 1 1 HAD-hyrolase-like S6PP PF05116.13 ELR22023.1 - 0.0062 16.1 0.0 0.0094 15.5 0.0 1.3 1 0 0 1 1 1 1 Sucrose-6F-phosphate phosphohydrolase Hydrolase_3 PF08282.12 ELR22023.1 - 0.061 13.1 0.4 0.96 9.1 0.0 2.4 3 0 0 3 3 3 0 haloacid dehalogenase-like hydrolase adh_short PF00106.25 ELR22024.1 - 3e-61 206.3 2.6 4.1e-61 205.8 2.6 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ELR22024.1 - 1.4e-55 188.4 3.0 1.4e-55 188.4 3.0 1.5 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ELR22024.1 - 1.4e-21 77.3 2.0 2.5e-21 76.4 2.0 1.4 1 0 0 1 1 1 1 KR domain Kelch_4 PF13418.6 ELR22024.1 - 3.5e-07 30.1 7.9 3.2e-05 23.8 0.3 3.5 2 1 1 3 3 3 2 Galactose oxidase, central domain Polysacc_synt_2 PF02719.15 ELR22024.1 - 0.00057 19.1 1.1 0.00076 18.7 0.2 1.7 2 0 0 2 2 2 1 Polysaccharide biosynthesis protein Epimerase PF01370.21 ELR22024.1 - 0.00094 18.7 0.9 0.0018 17.8 0.9 1.5 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 ELR22024.1 - 0.0019 18.1 1.5 0.0039 17.1 1.5 1.5 1 0 0 1 1 1 1 NAD(P)H-binding Kelch_3 PF13415.6 ELR22024.1 - 0.062 13.6 4.0 0.91 9.9 0.1 3.8 4 0 0 4 4 4 0 Galactose oxidase, central domain Kelch_1 PF01344.25 ELR22024.1 - 5 6.8 11.7 11 5.6 1.4 3.8 3 1 0 3 3 3 0 Kelch motif RVT_2 PF07727.14 ELR22025.1 - 5.7e-30 104.7 0.5 8.6e-21 74.7 0.0 2.1 1 1 1 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_1 PF00078.27 ELR22025.1 - 0.072 12.6 0.7 0.27 10.7 0.7 1.9 1 1 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) CwsA PF10814.8 ELR22026.1 - 0.26 11.5 1.1 0.64 10.2 0.9 1.7 1 1 1 2 2 2 0 Cell wall synthesis protein CwsA Beta_helix PF13229.6 ELR22027.1 - 1e-28 100.2 67.8 2.8e-13 50.0 11.5 4.7 2 2 3 5 5 5 5 Right handed beta helix region Cornifin PF02389.15 ELR22027.1 - 0.035 14.3 15.5 0.069 13.3 15.5 1.4 1 0 0 1 1 1 0 Cornifin (SPRR) family TrfA PF07042.11 ELR22027.1 - 0.14 11.2 0.0 14 4.6 0.0 2.2 2 0 0 2 2 2 0 TrfA protein Kinocilin PF15033.6 ELR22027.1 - 0.23 11.1 3.8 5.9 6.6 0.2 2.5 2 0 0 2 2 2 0 Kinocilin protein NmrA PF05368.13 ELR22028.1 - 1.2e-08 34.8 0.1 2.2e-08 34.0 0.1 1.4 1 1 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 ELR22028.1 - 0.00067 19.6 0.3 0.0015 18.5 0.3 1.5 1 1 0 1 1 1 1 NAD(P)H-binding Pkinase PF00069.25 ELR22029.1 - 1.7e-13 50.6 0.0 2.7e-13 49.9 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR22029.1 - 7.5e-07 28.7 0.0 1.2e-06 28.0 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 ELR22029.1 - 0.0096 14.7 0.0 0.014 14.2 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase UBX PF00789.20 ELR22030.1 - 8.6e-11 41.9 0.0 1.6e-10 41.1 0.0 1.4 1 0 0 1 1 1 1 UBX domain zf-RING_11 PF17123.5 ELR22030.1 - 1.1e-05 25.1 0.2 1.8e-05 24.3 0.2 1.4 1 0 0 1 1 1 1 RING-like zinc finger zf-RING_2 PF13639.6 ELR22030.1 - 2.5e-05 24.5 0.2 4e-05 23.9 0.2 1.3 1 0 0 1 1 1 1 Ring finger domain UBA PF00627.31 ELR22030.1 - 0.00013 21.8 0.1 0.00022 21.0 0.1 1.4 1 0 0 1 1 1 1 UBA/TS-N domain zf-RING_UBOX PF13445.6 ELR22030.1 - 0.026 14.6 0.2 0.045 13.8 0.2 1.4 1 0 0 1 1 1 0 RING-type zinc-finger zf-C3HC4 PF00097.25 ELR22030.1 - 0.19 11.6 0.2 0.32 10.9 0.2 1.3 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Rrn6 PF10214.9 ELR22030.1 - 0.19 10.2 2.1 0.26 9.7 2.1 1.1 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor zf-C3HC4_2 PF13923.6 ELR22030.1 - 0.2 11.6 0.3 0.34 10.8 0.3 1.3 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) GPCR_chapero_1 PF11904.8 ELR22031.1 - 7e-54 183.3 0.3 1.8e-52 178.7 0.3 2.1 1 1 0 1 1 1 1 GPCR-chaperone Ank_5 PF13857.6 ELR22031.1 - 7.8e-11 42.0 0.0 7.1e-06 26.2 0.0 2.8 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 ELR22031.1 - 9.1e-10 39.0 1.0 2.3e-08 34.5 0.1 2.6 2 1 1 3 3 3 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ELR22031.1 - 1.3e-06 28.8 0.0 0.0041 17.7 0.0 2.9 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 ELR22031.1 - 2.2e-06 27.8 0.8 0.00011 22.5 0.1 2.9 3 0 0 3 3 3 1 Ankyrin repeat Ank_3 PF13606.6 ELR22031.1 - 1.8e-05 24.8 0.1 0.0047 17.3 0.1 3.1 3 0 0 3 3 3 1 Ankyrin repeat DUF4412 PF14371.6 ELR22031.1 - 0.035 13.9 0.1 0.2 11.5 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4412) Ras PF00071.22 ELR22032.1 - 1.3e-50 171.1 0.0 1.6e-50 170.9 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR22032.1 - 4.3e-24 85.0 0.0 6.1e-24 84.5 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR22032.1 - 2.1e-12 46.9 0.0 2.4e-12 46.6 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 ELR22032.1 - 0.0006 19.4 0.0 0.0022 17.6 0.0 1.9 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 ELR22032.1 - 0.0095 15.3 0.0 0.014 14.7 0.0 1.3 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 ELR22032.1 - 0.048 13.8 0.0 0.072 13.2 0.0 1.3 1 0 0 1 1 1 0 50S ribosome-binding GTPase COMM_domain PF07258.14 ELR22033.1 - 2.2e-17 62.9 0.1 4e-17 62.1 0.1 1.5 1 0 0 1 1 1 1 COMM domain GST_C_3 PF14497.6 ELR22034.1 - 5.9e-22 77.7 0.0 1.1e-21 76.8 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 ELR22034.1 - 2.2e-07 31.0 0.1 3.6e-07 30.3 0.1 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 ELR22034.1 - 9.9e-05 22.6 0.0 0.00029 21.1 0.0 1.8 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 ELR22034.1 - 0.0065 16.5 1.9 0.041 13.9 0.6 2.6 2 1 0 2 2 2 1 Glutathione S-transferase, C-terminal domain SARAF PF06682.12 ELR22034.1 - 0.17 11.5 0.3 0.24 11.0 0.3 1.2 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis UDG PF03167.19 ELR22035.1 - 8e-21 74.6 0.0 1.4e-20 73.9 0.0 1.4 1 0 0 1 1 1 1 Uracil DNA glycosylase superfamily SAP PF02037.27 ELR22035.1 - 8.7e-14 50.9 0.0 1.5e-13 50.1 0.0 1.4 1 0 0 1 1 1 1 SAP domain P_C PF06640.11 ELR22035.1 - 0.0079 16.4 8.4 0.013 15.6 8.4 1.3 1 0 0 1 1 1 1 P protein C-terminus TFIIF_alpha PF05793.12 ELR22035.1 - 0.046 12.3 12.7 0.068 11.8 12.7 1.2 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) DTHCT PF08070.11 ELR22035.1 - 0.064 14.0 13.7 0.14 12.9 13.7 1.5 1 0 0 1 1 1 0 DTHCT (NUC029) region Nop14 PF04147.12 ELR22035.1 - 0.071 11.3 6.4 0.086 11.1 6.4 1.1 1 0 0 1 1 1 0 Nop14-like family DUF1860 PF08949.10 ELR22035.1 - 0.11 12.3 2.1 0.17 11.6 2.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1860) DNA_pol_phi PF04931.13 ELR22035.1 - 0.31 9.1 11.8 0.45 8.6 11.8 1.1 1 0 0 1 1 1 0 DNA polymerase phi PPP4R2 PF09184.11 ELR22035.1 - 0.53 9.8 8.8 0.94 9.0 8.8 1.3 1 0 0 1 1 1 0 PPP4R2 HeH PF12949.7 ELR22035.1 - 0.73 9.6 0.0 0.73 9.6 0.0 2.5 3 0 0 3 3 3 0 HeH/LEM domain eIF-3c_N PF05470.12 ELR22035.1 - 1.1 7.5 4.5 1.4 7.1 4.5 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 8 N-terminus NOA36 PF06524.12 ELR22035.1 - 1.2 8.3 8.3 2.5 7.3 8.3 1.4 1 0 0 1 1 1 0 NOA36 protein RNA_pol_Rpc4 PF05132.14 ELR22035.1 - 2.3 8.6 6.2 5.5 7.4 6.2 1.6 1 0 0 1 1 1 0 RNA polymerase III RPC4 DUF1840 PF08895.11 ELR22035.1 - 2.3 8.6 9.4 11 6.4 9.4 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF1840) CDC45 PF02724.14 ELR22035.1 - 2.5 6.3 12.3 3.5 5.8 12.3 1.1 1 0 0 1 1 1 0 CDC45-like protein CobT PF06213.12 ELR22035.1 - 2.6 7.4 12.8 4.6 6.6 12.8 1.3 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Polysacc_deac_1 PF01522.21 ELR22036.1 - 5.2e-22 78.0 0.0 1.2e-21 76.9 0.0 1.5 2 0 0 2 2 2 1 Polysaccharide deacetylase Polysacc_deac_2 PF04748.13 ELR22036.1 - 2.5e-06 26.8 0.0 4.1e-05 22.9 0.0 2.1 1 1 1 2 2 2 1 Divergent polysaccharide deacetylase Rimk_N PF18030.1 ELR22036.1 - 0.068 13.6 0.0 0.15 12.5 0.0 1.6 1 0 0 1 1 1 0 RimK PreATP-grasp domain PH PF00169.29 ELR22037.1 - 4.6e-10 39.9 0.0 8.6e-06 26.2 0.0 2.6 2 0 0 2 2 2 2 PH domain BUD22 PF09073.10 ELR22037.1 - 7.5e-07 28.8 29.6 4.2e-05 23.1 5.6 2.3 2 0 0 2 2 2 2 BUD22 Trp_oprn_chp PF09534.10 ELR22037.1 - 0.0089 15.8 2.6 0.027 14.3 0.7 2.2 2 0 0 2 2 2 1 Tryptophan-associated transmembrane protein (Trp_oprn_chp) SDA1 PF05285.12 ELR22037.1 - 0.043 13.2 28.0 0.34 10.3 2.6 2.2 2 0 0 2 2 2 0 SDA1 PH_11 PF15413.6 ELR22037.1 - 0.073 13.5 2.1 0.67 10.4 0.0 2.9 3 0 0 3 3 3 0 Pleckstrin homology domain adh_short_C2 PF13561.6 ELR22038.1 - 1e-55 188.9 8.6 1.6e-55 188.2 8.6 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 ELR22038.1 - 5.2e-46 156.6 6.8 1.7e-45 154.9 6.8 1.7 1 1 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 ELR22038.1 - 3e-12 46.8 4.1 4.1e-12 46.4 3.4 1.5 1 1 0 1 1 1 1 KR domain AdoHcyase_NAD PF00670.21 ELR22038.1 - 0.023 14.8 1.6 0.078 13.0 0.4 2.1 2 0 0 2 2 2 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain THF_DHG_CYH_C PF02882.19 ELR22038.1 - 0.04 13.2 0.3 0.079 12.3 0.3 1.6 1 0 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Peptidase_M20 PF01546.28 ELR22039.1 - 3.7e-29 101.9 0.1 5.2e-29 101.4 0.1 1.2 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 ELR22039.1 - 4.4e-08 33.0 0.7 2.7e-05 24.1 0.2 3.4 3 1 0 3 3 3 1 Peptidase dimerisation domain 2OG-FeII_Oxy_2 PF13532.6 ELR22040.1 - 5.3e-11 43.1 0.0 6.4e-11 42.8 0.0 1.1 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy PF03171.20 ELR22040.1 - 0.035 14.6 0.2 0.27 11.7 0.2 2.4 1 1 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily NHL PF01436.21 ELR22041.1 - 2.6e-20 71.4 6.3 2.1e-06 27.4 0.1 5.4 5 0 0 5 5 5 4 NHL repeat SGL PF08450.12 ELR22041.1 - 8.9e-07 28.7 1.4 0.031 13.8 0.1 3.6 2 2 2 4 4 4 3 SMP-30/Gluconolactonase/LRE-like region DUF5128 PF17170.4 ELR22041.1 - 0.00011 21.5 0.0 0.00018 20.8 0.0 1.3 1 0 0 1 1 1 1 6-bladed beta-propeller DUF4934 PF16288.5 ELR22041.1 - 0.00041 20.2 0.0 0.0073 16.2 0.0 2.4 2 1 0 2 2 2 1 Domain of unknown function (DUF4934) NOA36 PF06524.12 ELR22042.1 - 4.6 6.5 12.7 0.11 11.8 3.5 2.2 2 0 0 2 2 2 0 NOA36 protein Exo_endo_phos PF03372.23 ELR22043.1 - 1.2e-11 44.6 10.0 9.7e-11 41.6 10.0 2.0 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family CENP-B_dimeris PF09026.10 ELR22043.1 - 0.05 14.0 8.7 0.1 13.0 8.7 1.5 1 0 0 1 1 1 0 Centromere protein B dimerisation domain DUF2457 PF10446.9 ELR22043.1 - 0.14 11.3 6.0 0.19 10.8 6.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) NOA36 PF06524.12 ELR22043.1 - 0.19 11.0 6.7 0.26 10.6 6.7 1.1 1 0 0 1 1 1 0 NOA36 protein DNA_pol_phi PF04931.13 ELR22043.1 - 0.26 9.3 3.2 0.35 8.9 3.2 1.1 1 0 0 1 1 1 0 DNA polymerase phi PBP1_TM PF14812.6 ELR22043.1 - 0.75 10.2 9.4 0.46 10.9 6.9 1.9 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Cwf_Cwc_15 PF04889.12 ELR22043.1 - 0.78 9.4 7.0 1.1 8.9 7.0 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein DUF3295 PF11702.8 ELR22043.1 - 2.8 7.2 5.8 3.9 6.7 5.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3295) SE PF08491.10 ELR22044.1 - 1.7e-87 293.0 0.0 2.3e-87 292.6 0.0 1.2 1 0 0 1 1 1 1 Squalene epoxidase FAD_binding_3 PF01494.19 ELR22044.1 - 4.4e-16 59.1 0.1 9.7e-16 57.9 0.1 1.5 1 1 0 1 1 1 1 FAD binding domain DAO PF01266.24 ELR22044.1 - 1.3e-10 41.4 1.6 6.8e-05 22.6 0.3 2.3 2 0 0 2 2 2 2 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 ELR22044.1 - 5.1e-05 23.4 0.7 0.00015 22.0 0.7 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain GIDA PF01134.22 ELR22044.1 - 0.00013 21.2 1.8 0.00079 18.6 1.8 1.9 1 1 0 1 1 1 1 Glucose inhibited division protein A Pyr_redox_2 PF07992.14 ELR22044.1 - 0.00023 20.5 1.0 0.00027 20.3 0.1 1.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 ELR22044.1 - 0.0011 18.2 0.2 0.0049 16.2 0.1 1.9 2 0 0 2 2 2 1 Thi4 family FAD_binding_2 PF00890.24 ELR22044.1 - 0.004 16.3 1.5 0.004 16.3 1.5 1.6 2 0 0 2 2 2 1 FAD binding domain Trp_halogenase PF04820.14 ELR22044.1 - 0.0059 15.5 0.5 1.3 7.7 0.2 2.2 2 0 0 2 2 2 2 Tryptophan halogenase Lycopene_cycl PF05834.12 ELR22044.1 - 0.0073 15.4 0.2 0.014 14.4 0.2 1.4 1 0 0 1 1 1 1 Lycopene cyclase protein TrkA_N PF02254.18 ELR22044.1 - 0.01 16.1 1.6 0.049 13.9 0.2 2.5 3 0 0 3 3 2 0 TrkA-N domain HI0933_like PF03486.14 ELR22044.1 - 0.016 13.9 0.1 0.023 13.4 0.1 1.2 1 0 0 1 1 1 0 HI0933-like protein Shikimate_DH PF01488.20 ELR22044.1 - 0.029 14.4 0.1 0.11 12.5 0.0 2.0 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase NAD_Gly3P_dh_N PF01210.23 ELR22044.1 - 0.035 14.1 0.0 0.083 12.9 0.0 1.6 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus GMC_oxred_N PF00732.19 ELR22044.1 - 0.045 13.1 1.8 1.5 8.1 0.3 2.2 2 0 0 2 2 2 0 GMC oxidoreductase ApbA PF02558.16 ELR22044.1 - 0.047 13.3 0.3 0.093 12.4 0.3 1.5 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA 3HCDH_N PF02737.18 ELR22044.1 - 0.08 12.8 0.1 0.18 11.7 0.1 1.6 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain FAD_oxidored PF12831.7 ELR22044.1 - 0.091 12.1 4.0 0.14 11.4 4.0 1.4 1 1 0 1 1 1 0 FAD dependent oxidoreductase Pyr_redox PF00070.27 ELR22044.1 - 0.25 11.9 1.4 0.38 11.4 0.2 1.9 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase RRM_1 PF00076.22 ELR22045.1 - 1.2e-40 137.1 0.2 5.6e-10 38.9 0.0 5.5 5 0 0 5 5 5 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SPOC PF07744.13 ELR22045.1 - 6.9e-12 45.5 0.0 1.7e-11 44.2 0.0 1.7 1 0 0 1 1 1 1 SPOC domain RRM_3 PF08777.11 ELR22045.1 - 5.2e-05 23.2 0.0 1.3 9.2 0.0 3.8 3 0 0 3 3 3 2 RNA binding motif RRM_occluded PF16842.5 ELR22045.1 - 0.00063 19.6 0.0 0.84 9.5 0.0 3.7 5 0 0 5 5 5 2 Occluded RNA-recognition motif RRM_7 PF16367.5 ELR22045.1 - 0.012 15.7 0.0 9.3 6.4 0.0 3.8 3 0 0 3 3 3 0 RNA recognition motif DUF4523 PF15023.6 ELR22045.1 - 0.1 12.4 0.0 3.4 7.5 0.0 3.2 4 0 0 4 4 4 0 Protein of unknown function (DUF4523) Pyr_redox_2 PF07992.14 ELR22046.1 - 3.8e-13 49.3 0.1 3.3e-08 33.1 0.1 2.5 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase AlaDh_PNT_C PF01262.21 ELR22046.1 - 0.07 12.4 0.6 0.13 11.6 0.2 1.6 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain Pyr_redox PF00070.27 ELR22046.1 - 0.096 13.3 0.8 4.8 7.8 0.0 3.0 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase DUF3223 PF11523.8 ELR22047.1 - 6.9e-24 84.5 0.1 2e-23 83.1 0.1 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF3223) RRM_3 PF08777.11 ELR22047.1 - 1e-09 38.4 0.1 1e-09 38.4 0.1 2.8 2 1 1 3 3 3 1 RNA binding motif RRM_1 PF00076.22 ELR22047.1 - 0.0027 17.5 0.1 0.0054 16.5 0.1 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) GRP PF07172.11 ELR22047.1 - 2.5 8.8 16.9 7.6 7.3 9.5 2.7 3 0 0 3 3 3 0 Glycine rich protein family Jak1_Phl PF17887.1 ELR22047.1 - 3.8 7.5 5.5 0.77 9.7 0.3 2.3 2 1 1 3 3 3 0 Jak1 pleckstrin homology-like domain Beta-Casp PF10996.8 ELR22048.1 - 1e-26 93.3 0.0 3.7e-26 91.6 0.0 1.9 2 0 0 2 2 2 1 Beta-Casp domain Lactamase_B_6 PF16661.5 ELR22048.1 - 2.1e-21 76.2 0.0 4e-21 75.3 0.0 1.4 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily domain RMMBL PF07521.12 ELR22048.1 - 1.7e-18 66.3 0.0 4e-18 65.1 0.0 1.7 1 0 0 1 1 1 1 Zn-dependent metallo-hydrolase RNA specificity domain Lactamase_B PF00753.27 ELR22048.1 - 1.3e-12 48.2 0.1 2.5e-11 44.0 0.1 2.4 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 ELR22048.1 - 4.5e-12 45.9 0.0 1.1e-10 41.4 0.0 2.2 2 0 0 2 2 2 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 ELR22048.1 - 1.8e-05 24.7 0.0 6.6e-05 22.9 0.0 1.9 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Beta_lactamase3 PF17030.5 ELR22048.1 - 0.0063 15.8 0.1 0.02 14.1 0.0 1.8 2 1 0 2 2 2 1 Putative beta-lactamase-like family LRR_6 PF13516.6 ELR22049.1 - 5.8e-07 29.1 15.8 6.2 7.1 0.6 11.3 12 0 0 12 12 12 2 Leucine Rich repeat LRR_4 PF12799.7 ELR22049.1 - 1.6e-06 28.3 23.8 1.1 9.8 0.3 9.7 10 2 2 12 12 12 5 Leucine Rich repeats (2 copies) RHD3 PF05879.12 ELR22051.1 - 2.6e-191 637.6 3.4 4.4e-189 630.2 3.4 2.0 1 1 0 1 1 1 1 Root hair defective 3 GTP-binding protein (RHD3) GBP PF02263.19 ELR22051.1 - 2.9e-06 26.7 1.1 3.9e-06 26.3 0.1 1.6 2 0 0 2 2 2 1 Guanylate-binding protein, N-terminal domain MMR_HSR1 PF01926.23 ELR22051.1 - 0.00023 21.2 0.0 0.0013 18.7 0.0 2.3 2 0 0 2 2 2 1 50S ribosome-binding GTPase Dynamin_N PF00350.23 ELR22051.1 - 0.00063 19.8 0.3 0.0022 18.1 0.1 2.0 2 0 0 2 2 2 1 Dynamin family Ku_PK_bind PF08785.11 ELR22051.1 - 0.03 14.4 0.2 0.22 11.7 0.0 2.4 2 0 0 2 2 2 0 Ku C terminal domain like AAA_28 PF13521.6 ELR22051.1 - 0.07 13.4 0.1 0.07 13.4 0.1 3.2 4 0 0 4 4 4 0 AAA domain ABC_tran PF00005.27 ELR22051.1 - 0.21 12.1 1.1 0.8 10.2 0.0 2.4 2 1 0 2 2 2 0 ABC transporter DUF2207 PF09972.9 ELR22051.1 - 0.37 9.5 1.9 0.8 8.4 0.6 2.1 2 1 0 2 2 2 0 Predicted membrane protein (DUF2207) His_Phos_2 PF00328.22 ELR22052.1 - 5.6e-20 72.0 0.1 1e-15 58.0 0.0 2.6 2 1 0 2 2 2 2 Histidine phosphatase superfamily (branch 2) Cut12 PF11500.8 ELR22053.1 - 0.014 15.3 1.9 0.032 14.2 1.9 1.5 1 0 0 1 1 1 0 Spindle pole body formation-associated protein DivIC PF04977.15 ELR22053.1 - 0.099 12.4 1.2 0.18 11.6 1.2 1.3 1 0 0 1 1 1 0 Septum formation initiator DUF4449 PF14613.6 ELR22054.1 - 3.3e-05 24.0 0.1 6.7e-05 23.0 0.1 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF4449) Pkinase PF00069.25 ELR22055.1 - 2.4e-69 233.7 0.0 3.2e-69 233.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR22055.1 - 3.5e-31 108.4 0.0 4.9e-31 107.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase FYVE PF01363.21 ELR22055.1 - 7.9e-16 58.0 14.4 1.4e-15 57.2 14.4 1.4 1 0 0 1 1 1 1 FYVE zinc finger C2 PF00168.30 ELR22055.1 - 3.9e-08 33.5 0.0 7.3e-08 32.6 0.0 1.4 1 0 0 1 1 1 1 C2 domain Pkinase_C PF00433.24 ELR22055.1 - 2.9e-07 31.1 0.3 1.3e-06 29.0 0.3 2.2 1 0 0 1 1 1 1 Protein kinase C terminal domain Kinase-like PF14531.6 ELR22055.1 - 2.6e-05 23.7 0.0 9.9e-05 21.8 0.0 1.8 1 1 0 2 2 2 1 Kinase-like FTA2 PF13095.6 ELR22055.1 - 0.0052 16.4 0.1 1.5 8.4 0.1 2.7 3 0 0 3 3 3 2 Kinetochore Sim4 complex subunit FTA2 APH PF01636.23 ELR22055.1 - 0.097 12.6 0.0 0.18 11.7 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family IBR PF01485.21 ELR22055.1 - 9.1 6.6 11.6 0.31 11.3 5.4 1.7 2 0 0 2 2 2 0 IBR domain, a half RING-finger domain GAS2 PF02187.17 ELR22056.1 - 0.0036 17.4 0.0 0.0068 16.5 0.0 1.4 1 0 0 1 1 1 1 Growth-Arrest-Specific Protein 2 Domain DUF4449 PF14613.6 ELR22056.1 - 0.0049 17.0 0.0 0.016 15.3 0.0 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF4449) NKAP PF15692.5 ELR22057.1 - 0.00084 20.0 6.8 0.00084 20.0 6.8 4.1 3 2 0 3 3 3 1 NF-kappa-B-activating protein Choline_kinase PF01633.20 ELR22058.1 - 0.032 13.8 0.0 0.078 12.6 0.0 1.6 1 1 0 1 1 1 0 Choline/ethanolamine kinase YfcL PF08891.11 ELR22058.1 - 1.1 9.7 4.8 0.37 11.2 1.8 1.8 2 0 0 2 2 2 0 YfcL protein DCX PF03607.17 ELR22059.1 - 1.7e-07 31.3 0.0 2.5e-07 30.7 0.0 1.2 1 0 0 1 1 1 1 Doublecortin Fringe PF02434.16 ELR22059.1 - 0.058 12.8 0.0 0.089 12.2 0.0 1.3 1 0 0 1 1 1 0 Fringe-like Tim44 PF04280.15 ELR22060.1 - 2.6e-23 82.8 0.0 5.7e-23 81.6 0.0 1.6 1 0 0 1 1 1 1 Tim44-like domain Retrotrans_gag PF03732.17 ELR22060.1 - 0.00089 19.5 1.1 0.0034 17.6 0.7 2.2 2 0 0 2 2 2 1 Retrotransposon gag protein DUF1664 PF07889.12 ELR22060.1 - 0.0079 16.2 1.0 0.0079 16.2 1.0 2.8 2 1 1 3 3 3 1 Protein of unknown function (DUF1664) Elf4 PF07011.11 ELR22060.1 - 0.054 13.4 0.5 0.48 10.4 0.1 2.6 3 0 0 3 3 3 0 Early Flowering 4 domain DASH_Duo1 PF08651.10 ELR22060.1 - 0.18 11.6 3.4 0.28 11.0 0.2 2.6 2 1 0 2 2 2 0 DASH complex subunit Duo1 HHH_2 PF12826.7 ELR22060.1 - 0.26 11.4 0.9 1.8 8.7 0.2 2.6 3 0 0 3 3 3 0 Helix-hairpin-helix motif DUF3829 PF12889.7 ELR22060.1 - 0.67 9.4 7.5 0.34 10.4 4.9 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3829) Nup88 PF10168.9 ELR22060.1 - 0.83 7.4 7.8 1.4 6.7 7.8 1.3 1 0 0 1 1 1 0 Nuclear pore component YkyA PF10368.9 ELR22060.1 - 0.94 9.1 17.0 0.16 11.6 0.8 2.9 3 0 0 3 3 3 0 Putative cell-wall binding lipoprotein MTBP_N PF14918.6 ELR22060.1 - 1.2 8.6 9.3 0.11 12.0 4.0 1.9 1 1 1 2 2 2 0 MDM2-binding DUF16 PF01519.16 ELR22060.1 - 1.8 9.1 14.4 2.3 8.8 3.3 2.8 1 1 1 2 2 2 0 Protein of unknown function DUF16 SesA PF17107.5 ELR22060.1 - 1.9 8.7 9.2 0.96 9.6 0.2 3.1 3 0 0 3 3 3 0 N-terminal domain on NACHT_NTPase and P-loop NTPases KxDL PF10241.9 ELR22060.1 - 2 8.8 13.2 9.5 6.6 5.5 3.7 2 1 2 4 4 4 0 Uncharacterized conserved protein MCR_C PF04609.12 ELR22060.1 - 3.6 6.6 5.3 1.4 7.9 0.5 2.5 2 1 1 3 3 3 0 Methyl-coenzyme M reductase operon protein C DUF4795 PF16043.5 ELR22060.1 - 4 7.0 12.5 12 5.4 12.5 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4795) COG2 PF06148.11 ELR22060.1 - 4.3 7.4 16.8 0.26 11.4 1.7 3.8 3 1 2 5 5 5 0 COG (conserved oligomeric Golgi) complex component, COG2 Occludin_ELL PF07303.13 ELR22060.1 - 9.1 7.1 9.9 4.5 8.1 2.0 2.7 3 0 0 3 3 2 0 Occludin homology domain rve PF00665.26 ELR22061.1 - 3.2e-10 40.2 0.0 4.9e-10 39.6 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain gag_pre-integrs PF13976.6 ELR22062.1 - 0.00012 21.8 0.0 0.00038 20.3 0.0 1.9 1 0 0 1 1 1 1 GAG-pre-integrase domain Pescadillo_N PF06732.11 ELR22063.1 - 4.9e-110 367.4 0.3 9.3e-110 366.5 0.3 1.4 1 0 0 1 1 1 1 Pescadillo N-terminus BRCT_2 PF16589.5 ELR22063.1 - 1.6e-08 34.8 0.0 3.3e-08 33.8 0.0 1.5 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain BRCT PF00533.26 ELR22063.1 - 0.0029 18.0 0.0 0.0098 16.3 0.0 1.9 2 0 0 2 2 2 1 BRCA1 C Terminus (BRCT) domain T2SSG PF08334.11 ELR22063.1 - 0.12 12.5 0.0 0.3 11.2 0.0 1.7 1 0 0 1 1 1 0 Type II secretion system (T2SS), protein G GLTSCR1 PF15249.6 ELR22063.1 - 1.7 9.1 6.2 14 6.2 0.2 2.9 1 1 1 2 2 2 0 Conserved region of unknown function on GLTSCR protein eIF2A PF08662.11 ELR22064.1 - 4.9e-66 222.3 0.0 9.4e-65 218.1 0.0 2.3 2 0 0 2 2 2 1 Eukaryotic translation initiation factor eIF2A WD40 PF00400.32 ELR22064.1 - 0.066 14.1 1.7 14 6.7 0.1 3.8 4 0 0 4 4 4 0 WD domain, G-beta repeat PD40 PF07676.12 ELR22064.1 - 0.18 11.7 0.1 0.18 11.7 0.1 2.9 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat PGA2 PF07543.12 ELR22064.1 - 9 6.3 15.6 6 6.8 11.4 2.3 2 0 0 2 2 2 0 Protein trafficking PGA2 YCII PF03795.14 ELR22066.1 - 3.8e-12 46.4 0.1 4.7e-12 46.1 0.1 1.1 1 0 0 1 1 1 1 YCII-related domain DUF525 PF04379.14 ELR22067.1 - 0.00074 19.7 0.0 0.0012 19.0 0.0 1.4 1 0 0 1 1 1 1 ApaG domain ABC_membrane_2 PF06472.15 ELR22068.1 - 1.6e-23 83.5 0.0 5.6e-23 81.7 0.0 1.7 2 1 0 2 2 2 1 ABC transporter transmembrane region 2 KBP_C PF12309.8 ELR22069.1 - 3.7 7.0 14.1 0.16 11.5 1.8 2.4 2 0 0 2 2 2 0 KIF-1 binding protein C terminal CCDC53 PF10152.9 ELR22070.1 - 2.9e-42 144.7 0.0 3.8e-42 144.3 0.0 1.1 1 0 0 1 1 1 1 Subunit CCDC53 of WASH complex Ribosomal_60s PF00428.19 ELR22070.1 - 0.012 16.2 1.9 2.8 8.6 0.2 2.2 2 0 0 2 2 2 0 60s Acidic ribosomal protein DUF4623 PF15416.6 ELR22070.1 - 0.12 10.9 0.0 0.18 10.4 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4623) UQ_con PF00179.26 ELR22071.1 - 1.9e-42 144.2 0.0 2.2e-42 144.1 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 ELR22071.1 - 0.0036 17.0 0.0 0.004 16.9 0.0 1.1 1 0 0 1 1 1 1 Prokaryotic E2 family B RNA_pol_Rpb2_6 PF00562.28 ELR22072.1 - 1.9e-128 428.9 0.7 3e-128 428.2 0.7 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.15 ELR22072.1 - 1.8e-68 230.1 0.1 2.6e-68 229.5 0.1 1.2 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_2 PF04561.14 ELR22072.1 - 3.2e-53 180.2 0.1 8.8e-53 178.8 0.1 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_7 PF04560.20 ELR22072.1 - 9.8e-36 122.0 0.2 4.1e-35 120.1 0.2 2.2 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_3 PF04565.16 ELR22072.1 - 7.1e-27 93.4 0.0 1.9e-26 92.0 0.0 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_4 PF04566.13 ELR22072.1 - 3.6e-24 84.8 0.2 9.9e-24 83.4 0.2 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 4 RNA_pol_Rpb2_5 PF04567.17 ELR22072.1 - 1.3e-21 76.9 1.9 5.4e-21 74.9 1.9 2.2 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 5 Chorismate_bind PF00425.18 ELR22073.1 - 3.8e-66 223.3 0.0 3.8e-42 144.6 0.0 2.8 2 1 1 3 3 3 2 chorismate binding enzyme GATase PF00117.28 ELR22073.1 - 8e-38 130.1 0.0 1.2e-37 129.5 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Anth_synt_I_N PF04715.13 ELR22073.1 - 1.9e-15 57.3 0.0 6.8e-15 55.5 0.0 2.0 2 0 0 2 2 2 1 Anthranilate synthase component I, N terminal region Peptidase_C26 PF07722.13 ELR22073.1 - 1.5e-09 37.9 0.4 2.5e-09 37.2 0.4 1.3 1 0 0 1 1 1 1 Peptidase C26 Aminotran_4 PF01063.19 ELR22074.1 - 6.3e-25 88.3 0.0 3.5e-24 85.9 0.0 2.1 1 1 0 1 1 1 1 Amino-transferase class IV Mur_ligase_M PF08245.12 ELR22074.1 - 1.5e-14 54.5 0.0 8.4e-14 52.0 0.0 2.3 1 1 0 1 1 1 1 Mur ligase middle domain DUF3141 PF11339.8 ELR22074.1 - 0.036 12.5 0.2 0.051 12.0 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3141) Pantoate_transf PF02548.15 ELR22074.1 - 0.14 11.6 0.1 0.25 10.7 0.1 1.3 1 0 0 1 1 1 0 Ketopantoate hydroxymethyltransferase SSP160 PF06933.11 ELR22074.1 - 6.2 4.9 6.6 9.1 4.3 6.6 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 DCP2 PF05026.13 ELR22075.1 - 4.7e-32 110.2 1.8 7.5e-32 109.5 1.8 1.3 1 0 0 1 1 1 1 Dcp2, box A domain NUDIX PF00293.28 ELR22075.1 - 4.8e-14 52.5 0.0 9.9e-14 51.5 0.0 1.5 1 0 0 1 1 1 1 NUDIX domain MFS_1 PF07690.16 ELR22076.1 - 0.023 13.6 0.0 0.03 13.3 0.0 1.1 1 0 0 1 1 1 0 Major Facilitator Superfamily PH PF00169.29 ELR22077.1 - 3.5e-10 40.3 0.0 5.5e-10 39.7 0.0 1.3 1 0 0 1 1 1 1 PH domain PH_11 PF15413.6 ELR22077.1 - 0.0028 18.0 0.1 0.006 17.0 0.1 1.6 1 1 0 1 1 1 1 Pleckstrin homology domain PH_3 PF14593.6 ELR22077.1 - 0.012 15.7 0.0 0.019 15.1 0.0 1.3 1 1 0 1 1 1 0 PH domain G6PD_C PF02781.16 ELR22078.1 - 1.6e-85 286.8 0.0 2e-57 194.6 0.0 3.0 1 1 1 2 2 2 2 Glucose-6-phosphate dehydrogenase, C-terminal domain G6PD_N PF00479.22 ELR22078.1 - 1.6e-61 208.1 0.2 2.6e-61 207.3 0.2 1.4 1 0 0 1 1 1 1 Glucose-6-phosphate dehydrogenase, NAD binding domain GATA PF00320.27 ELR22079.1 - 1.2e-14 53.6 3.6 3e-14 52.3 3.6 1.7 1 0 0 1 1 1 1 GATA zinc finger SR-25 PF10500.9 ELR22079.1 - 0.034 13.8 27.4 0.055 13.1 8.1 3.2 3 0 0 3 3 3 0 Nuclear RNA-splicing-associated protein FAM176 PF14851.6 ELR22079.1 - 1.2 8.8 7.3 0.48 10.1 1.5 2.3 2 0 0 2 2 2 0 FAM176 family FAM60A PF15396.6 ELR22079.1 - 1.5 8.8 14.8 2 8.4 1.1 2.9 3 0 0 3 3 3 0 Protein Family FAM60A ECH_1 PF00378.20 ELR22080.1 - 7e-70 235.2 0.4 8.9e-70 234.9 0.4 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 ELR22080.1 - 8.5e-27 94.5 0.6 1.2e-26 94.0 0.6 1.3 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase MPTase-PolyVal PF18818.1 ELR22081.1 - 0.077 13.0 0.0 0.099 12.7 0.0 1.1 1 0 0 1 1 1 0 Metallopeptidase superfamily domain COR PF16095.5 ELR22082.1 - 2.2e-08 34.2 0.0 3e-08 33.7 0.0 1.2 1 0 0 1 1 1 1 C-terminal of Roc, COR, domain Lipase_3 PF01764.25 ELR22083.1 - 4.1e-05 23.5 0.0 7.3e-05 22.7 0.0 1.4 1 0 0 1 1 1 1 Lipase (class 3) PGAP1 PF07819.13 ELR22083.1 - 0.056 13.2 0.0 0.1 12.3 0.0 1.3 1 0 0 1 1 1 0 PGAP1-like protein DUF2974 PF11187.8 ELR22083.1 - 0.16 11.5 0.0 0.41 10.2 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2974) AhpC-TSA PF00578.21 ELR22084.1 - 1.1e-36 125.5 0.0 1.5e-36 125.1 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 ELR22084.1 - 8.7e-19 67.7 0.0 1.1e-18 67.3 0.0 1.1 1 0 0 1 1 1 1 Redoxin 1-cysPrx_C PF10417.9 ELR22084.1 - 1.7e-15 56.6 0.1 3.6e-15 55.5 0.1 1.6 1 0 0 1 1 1 1 C-terminal domain of 1-Cys peroxiredoxin SCO1-SenC PF02630.14 ELR22084.1 - 0.00025 20.9 0.1 0.00079 19.3 0.1 1.8 2 0 0 2 2 2 1 SCO1/SenC Fe-S_biosyn PF01521.20 ELR22085.1 - 1.5e-20 73.4 0.0 1.8e-20 73.2 0.0 1.0 1 0 0 1 1 1 1 Iron-sulphur cluster biosynthesis Coatomer_E PF04733.14 ELR22086.1 - 8e-90 301.2 0.1 9e-90 301.0 0.1 1.0 1 0 0 1 1 1 1 Coatomer epsilon subunit TPR_19 PF14559.6 ELR22086.1 - 1.9e-05 25.1 5.0 0.043 14.3 0.0 4.1 4 1 1 5 5 5 2 Tetratricopeptide repeat TPR_17 PF13431.6 ELR22086.1 - 0.00044 20.4 0.0 0.003 17.8 0.0 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat ThiS-like PF14453.6 ELR22086.1 - 0.0084 16.1 0.0 0.022 14.8 0.0 1.7 1 0 0 1 1 1 1 ThiS-like ubiquitin TPR_7 PF13176.6 ELR22086.1 - 0.041 13.9 0.0 12 6.2 0.0 3.7 4 1 0 4 4 4 0 Tetratricopeptide repeat Utp13 PF08625.11 ELR22086.1 - 0.057 13.3 0.1 0.19 11.6 0.0 1.9 2 0 0 2 2 2 0 Utp13 specific WD40 associated domain TPR_14 PF13428.6 ELR22086.1 - 0.058 14.2 1.9 1.7 9.7 0.0 3.9 2 1 3 5 5 5 0 Tetratricopeptide repeat Inhibitor_Mig-6 PF11555.8 ELR22086.1 - 0.19 11.8 0.0 0.64 10.2 0.0 1.8 2 0 0 2 2 2 0 EGFR receptor inhibitor Mig-6 Beach PF02138.18 ELR22088.1 - 1.2e-115 385.7 0.0 1.8e-115 385.1 0.0 1.3 1 0 0 1 1 1 1 Beige/BEACH domain PH_BEACH PF14844.6 ELR22088.1 - 7.1e-11 42.1 0.0 1.3e-10 41.3 0.0 1.5 1 0 0 1 1 1 1 PH domain associated with Beige/BEACH Laminin_G_3 PF13385.6 ELR22088.1 - 9.2e-07 29.1 0.1 2.6e-06 27.7 0.1 1.7 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily WD40 PF00400.32 ELR22088.1 - 1.3e-06 29.0 1.2 0.94 10.5 0.1 4.9 4 0 0 4 4 4 2 WD domain, G-beta repeat HD_assoc PF13286.6 ELR22089.1 - 8.8e-17 61.4 1.1 1.8e-07 31.6 0.1 3.2 3 0 0 3 3 3 2 Phosphohydrolase-associated domain HD PF01966.22 ELR22089.1 - 7.4e-16 58.5 0.0 1.8e-15 57.2 0.0 1.7 1 0 0 1 1 1 1 HD domain Thiolase_C PF02803.18 ELR22089.1 - 0.028 14.1 0.6 0.22 11.2 0.6 2.1 1 1 0 1 1 1 0 Thiolase, C-terminal domain HD_2 PF12917.7 ELR22089.1 - 0.12 12.1 0.0 0.47 10.2 0.0 1.9 2 0 0 2 2 2 0 HD containing hydrolase-like enzyme Pkinase_Tyr PF07714.17 ELR22090.1 - 1.8e-72 243.8 0.2 5.3e-72 242.2 0.0 1.8 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.25 ELR22090.1 - 1.4e-47 162.3 0.0 4.9e-47 160.5 0.0 1.8 2 0 0 2 2 2 1 Protein kinase domain Kinase-like PF14531.6 ELR22090.1 - 2.1e-05 24.0 0.1 0.0001 21.8 0.0 2.0 2 0 0 2 2 2 1 Kinase-like FTA2 PF13095.6 ELR22090.1 - 0.00035 20.3 2.2 0.14 11.8 0.0 3.2 3 0 0 3 3 3 2 Kinetochore Sim4 complex subunit FTA2 Pkinase_fungal PF17667.1 ELR22090.1 - 0.00069 18.5 2.8 0.0014 17.5 0.0 2.1 2 0 0 2 2 2 1 Fungal protein kinase Kdo PF06293.14 ELR22090.1 - 0.0016 17.8 0.0 0.0036 16.7 0.0 1.6 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 ELR22090.1 - 0.0032 16.5 0.0 0.0082 15.1 0.0 1.6 1 0 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 ELR22090.1 - 0.0083 16.1 0.1 0.031 14.2 0.1 1.7 1 1 1 2 2 2 1 Phosphotransferase enzyme family SKG6 PF08693.10 ELR22090.1 - 0.018 14.4 0.6 0.018 14.4 0.6 1.9 2 0 0 2 2 2 0 Transmembrane alpha-helix domain zinc_ribbon_16 PF17034.5 ELR22091.1 - 6.6e-24 84.5 9.9 1.3e-23 83.5 9.9 1.5 1 0 0 1 1 1 1 Zinc-ribbon like family WD40 PF00400.32 ELR22091.1 - 2.4 9.2 8.8 61 4.7 0.1 5.0 5 1 1 6 6 6 0 WD domain, G-beta repeat Cys_rich_CPCC PF14206.6 ELR22092.1 - 9.6e-12 44.6 1.4 5e-08 32.7 0.0 2.1 1 1 1 2 2 2 2 Cysteine-rich CPCC NDUF_C2 PF06374.11 ELR22093.1 - 0.048 13.8 0.3 0.1 12.8 0.2 1.6 1 1 0 1 1 1 0 NADH-ubiquinone oxidoreductase subunit b14.5b (NDUFC2) Erf4 PF10256.9 ELR22094.1 - 0.0029 17.7 0.0 0.0036 17.4 0.0 1.1 1 0 0 1 1 1 1 Golgin subfamily A member 7/ERF4 family US6 PF17616.2 ELR22095.1 - 0.3 11.0 2.6 0.53 10.2 2.6 1.3 1 0 0 1 1 1 0 Viral unique short region 6 DUF3693 PF12472.8 ELR22095.1 - 0.4 10.4 1.8 3.7 7.3 0.7 2.4 2 0 0 2 2 2 0 Phage related protein YlaC PF10777.9 ELR22095.1 - 1.7 8.5 3.8 2.9 7.7 3.8 1.3 1 0 0 1 1 1 0 Inner membrane protein YlaC TMEM100 PF16311.5 ELR22095.1 - 6.2 6.4 5.7 4.7 6.8 3.7 1.7 2 0 0 2 2 2 0 Transmembrane protein 100 Erf4 PF10256.9 ELR22096.1 - 0.00021 21.4 0.0 0.018 15.1 0.0 2.2 2 0 0 2 2 2 2 Golgin subfamily A member 7/ERF4 family EamA PF00892.20 ELR22096.1 - 0.52 10.5 10.2 1.1 9.5 10.2 1.5 1 1 0 1 1 1 0 EamA-like transporter family Otopetrin PF03189.13 ELR22096.1 - 2.7 6.7 6.0 5.5 5.7 6.2 1.3 1 1 0 1 1 1 0 Otopetrin DUF3611 PF12263.8 ELR22097.1 - 0.014 15.3 0.4 0.023 14.6 0.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3611) FA_desaturase PF00487.24 ELR22097.1 - 0.14 12.0 4.5 0.15 11.9 4.5 1.1 1 0 0 1 1 1 0 Fatty acid desaturase ABC2_membrane_3 PF12698.7 ELR22097.1 - 1.3 8.1 9.7 1.5 7.8 9.7 1.0 1 0 0 1 1 1 0 ABC-2 family transporter protein adh_short PF00106.25 ELR22098.1 - 7.6e-20 71.2 0.0 9.6e-09 35.0 0.0 2.4 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 ELR22098.1 - 4.2e-16 59.2 0.0 7.9e-10 38.7 0.0 2.2 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase NAM-associated PF14303.6 ELR22098.1 - 0.12 13.1 12.3 0.19 12.4 12.3 1.3 1 0 0 1 1 1 0 No apical meristem-associated C-terminal domain Nucleo_P87 PF07267.11 ELR22098.1 - 0.99 8.2 7.1 0.53 9.1 4.6 1.7 2 0 0 2 2 2 0 Nucleopolyhedrovirus capsid protein P87 Ric8 PF10165.9 ELR22099.1 - 2.3e-35 122.5 0.0 1.1e-34 120.3 0.0 1.8 2 0 0 2 2 2 1 Guanine nucleotide exchange factor synembryn Myc_N PF01056.18 ELR22099.1 - 0.091 12.6 0.8 0.19 11.6 0.8 1.4 1 0 0 1 1 1 0 Myc amino-terminal region Ribosomal_60s PF00428.19 ELR22099.1 - 0.11 13.1 1.7 0.27 11.9 1.7 1.7 1 0 0 1 1 1 0 60s Acidic ribosomal protein Nop14 PF04147.12 ELR22101.1 - 0.032 12.4 25.2 0.038 12.2 25.2 1.0 1 0 0 1 1 1 0 Nop14-like family DDHD PF02862.17 ELR22101.1 - 0.22 11.7 3.1 0.27 11.3 3.1 1.3 1 0 0 1 1 1 0 DDHD domain RRN3 PF05327.11 ELR22101.1 - 0.67 8.4 10.8 0.62 8.5 10.8 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 RR_TM4-6 PF06459.12 ELR22101.1 - 1.3 8.8 16.9 1.6 8.5 16.9 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF913 PF06025.12 ELR22101.1 - 1.5 7.7 4.5 1.7 7.5 4.5 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Drc1-Sld2 PF11719.8 ELR22101.1 - 4.9 6.6 18.8 5.5 6.4 18.8 1.0 1 0 0 1 1 1 0 DNA replication and checkpoint protein SAPS PF04499.15 ELR22101.1 - 6.5 5.4 12.3 7.2 5.3 12.3 1.0 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Hid1 PF12722.7 ELR22101.1 - 7.7 4.5 7.4 7.7 4.5 7.4 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein GATA PF00320.27 ELR22102.1 - 1.1e-14 53.8 8.2 1.9e-14 53.0 8.2 1.4 1 0 0 1 1 1 1 GATA zinc finger Nop53 PF07767.11 ELR22102.1 - 0.024 14.1 11.7 0.038 13.4 11.7 1.3 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) DUF1387 PF07139.11 ELR22102.1 - 0.085 12.6 9.8 0.13 12.0 9.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) Macoilin PF09726.9 ELR22102.1 - 1.1 7.8 6.5 1.9 6.9 6.4 1.3 1 0 0 1 1 1 0 Macoilin family GREB1 PF15782.5 ELR22102.1 - 1.5 5.8 4.5 1.8 5.6 4.5 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer DUF4636 PF15468.6 ELR22102.1 - 4.4 6.9 13.7 0.23 11.2 6.4 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4636) Macoilin PF09726.9 ELR22103.1 - 1.4 7.4 16.8 2.1 6.8 16.8 1.2 1 0 0 1 1 1 0 Macoilin family Plasmodium_Vir PF05795.11 ELR22103.1 - 1.9 7.8 9.1 2.8 7.3 9.1 1.1 1 0 0 1 1 1 0 Plasmodium vivax Vir protein TraH PF06122.11 ELR22103.1 - 2.8 7.1 6.0 4.2 6.5 6.0 1.2 1 0 0 1 1 1 0 Conjugative relaxosome accessory transposon protein NOA36 PF06524.12 ELR22104.1 - 0.026 13.9 2.2 0.038 13.3 2.2 1.2 1 0 0 1 1 1 0 NOA36 protein TFIIF_alpha PF05793.12 ELR22104.1 - 0.22 10.0 6.8 0.31 9.6 6.8 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) NmrA PF05368.13 ELR22105.1 - 8.2e-44 149.9 2.7 1.5e-42 145.8 2.7 2.0 1 1 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 ELR22105.1 - 5.6e-12 45.9 0.5 1.2e-11 44.9 0.5 1.5 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 ELR22105.1 - 0.0047 16.4 0.1 0.014 14.9 0.0 1.7 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family DapB_N PF01113.20 ELR22105.1 - 0.0057 16.8 0.1 0.014 15.5 0.1 1.6 1 0 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus KR PF08659.10 ELR22105.1 - 0.021 14.8 0.1 0.031 14.2 0.1 1.4 1 0 0 1 1 1 0 KR domain Peptidase_M28 PF04389.17 ELR22107.1 - 8.8e-38 130.0 0.0 2.5e-37 128.5 0.0 1.7 2 0 0 2 2 2 1 Peptidase family M28 Peptidase_M20 PF01546.28 ELR22107.1 - 7e-05 22.6 0.0 0.00031 20.5 0.0 2.1 3 0 0 3 3 3 1 Peptidase family M20/M25/M40 PA PF02225.22 ELR22107.1 - 0.002 18.1 0.0 0.007 16.4 0.0 1.9 2 0 0 2 2 2 1 PA domain Peptidase_M42 PF05343.14 ELR22107.1 - 0.002 17.2 0.0 0.011 14.8 0.0 1.9 2 0 0 2 2 2 1 M42 glutamyl aminopeptidase Nicastrin PF05450.15 ELR22107.1 - 0.0049 16.4 0.0 0.0086 15.6 0.0 1.3 1 0 0 1 1 1 1 Nicastrin DUF755 PF05501.11 ELR22108.1 - 0.078 13.3 0.6 0.078 13.3 0.6 2.7 2 1 0 2 2 2 0 Domain of unknown function (DUF755) GreA_GreB_N PF03449.15 ELR22108.1 - 0.093 12.9 1.0 0.25 11.5 0.1 2.1 2 0 0 2 2 2 0 Transcription elongation factor, N-terminal Activator_LAG-3 PF11498.8 ELR22108.1 - 1 8.3 13.2 4.3 6.2 12.8 2.2 1 1 1 2 2 2 0 Transcriptional activator LAG-3 Vac7 PF12751.7 ELR22108.1 - 1.7 8.0 11.3 0.073 12.5 5.6 1.5 2 0 0 2 2 2 0 Vacuolar segregation subunit 7 DUF2917 PF11142.8 ELR22109.1 - 0.095 12.1 0.0 0.31 10.5 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2917) PIF1 PF05970.14 ELR22110.1 - 1.9e-57 195.1 0.0 1e-43 149.9 0.1 2.2 2 0 0 2 2 2 2 PIF1-like helicase AAA_30 PF13604.6 ELR22110.1 - 2.4e-23 82.9 0.0 1.1e-22 80.8 0.0 1.9 1 1 1 2 2 2 1 AAA domain AAA_19 PF13245.6 ELR22110.1 - 2e-08 34.7 0.0 4.3e-08 33.6 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 ELR22110.1 - 4.6e-06 27.0 0.0 2e-05 24.9 0.0 2.1 1 1 0 1 1 1 1 AAA domain Herpes_Helicase PF02689.14 ELR22110.1 - 0.00058 17.9 0.1 0.014 13.4 0.0 2.2 2 0 0 2 2 2 1 Helicase AAA_16 PF13191.6 ELR22110.1 - 0.0071 16.8 0.2 0.088 13.2 0.0 2.3 2 0 0 2 2 2 1 AAA ATPase domain UvrD_C_2 PF13538.6 ELR22110.1 - 0.011 15.6 0.1 0.029 14.2 0.1 1.8 1 1 0 1 1 1 0 UvrD-like helicase C-terminal domain AAA_5 PF07728.14 ELR22110.1 - 0.017 15.1 0.0 0.055 13.5 0.0 1.9 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_24 PF13479.6 ELR22110.1 - 0.023 14.4 0.0 0.048 13.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain DEAD PF00270.29 ELR22110.1 - 0.029 14.1 0.2 2.5 7.8 0.0 2.4 2 0 0 2 2 2 0 DEAD/DEAH box helicase AAA PF00004.29 ELR22110.1 - 0.04 14.3 0.1 0.09 13.2 0.1 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Mg_chelatase PF01078.21 ELR22110.1 - 0.059 12.8 0.1 0.11 11.9 0.1 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI ATPase_2 PF01637.18 ELR22110.1 - 0.064 13.2 0.1 0.46 10.4 0.1 2.2 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea DUF2075 PF09848.9 ELR22110.1 - 0.065 12.5 0.5 0.13 11.4 0.0 1.7 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) AAA_11 PF13086.6 ELR22110.1 - 0.073 12.8 5.7 7.9 6.2 0.1 3.3 3 0 0 3 3 3 0 AAA domain AAA_14 PF13173.6 ELR22110.1 - 0.11 12.5 0.0 0.33 11.0 0.0 1.8 1 1 0 1 1 1 0 AAA domain Viral_helicase1 PF01443.18 ELR22110.1 - 0.13 12.0 1.0 2.8 7.6 1.0 2.7 2 1 0 2 2 2 0 Viral (Superfamily 1) RNA helicase NACHT PF05729.12 ELR22110.1 - 0.15 11.9 0.0 0.33 10.8 0.0 1.5 1 0 0 1 1 1 0 NACHT domain Ribosomal_60s PF00428.19 ELR22110.1 - 1.2 9.8 0.0 1.2 9.8 0.0 3.3 3 0 0 3 3 2 0 60s Acidic ribosomal protein fn3 PF00041.21 ELR22111.1 - 1.9e-07 31.3 0.1 3.5e-07 30.5 0.1 1.5 1 0 0 1 1 1 1 Fibronectin type III domain CAP PF00188.26 ELR22111.1 - 0.00026 21.8 2.2 0.00056 20.7 2.2 1.6 1 0 0 1 1 1 1 Cysteine-rich secretory protein family Peptidase_C1 PF00112.23 ELR22112.1 - 1.9e-41 142.6 8.1 3e-41 141.9 8.1 1.3 1 0 0 1 1 1 1 Papain family cysteine protease Peptidase_C1_2 PF03051.15 ELR22112.1 - 0.0021 16.9 0.4 0.0035 16.2 0.4 1.2 1 0 0 1 1 1 1 Peptidase C1-like family PP2 PF14299.6 ELR22113.1 - 0.00016 21.8 0.1 0.00027 21.0 0.1 1.3 1 0 0 1 1 1 1 Phloem protein 2 F-box PF00646.33 ELR22113.1 - 0.00074 19.3 0.2 0.0013 18.5 0.2 1.4 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 ELR22113.1 - 0.038 13.9 0.1 0.089 12.7 0.1 1.5 1 0 0 1 1 1 0 F-box-like RRM_1 PF00076.22 ELR22116.1 - 3e-19 68.6 2.0 1.4e-08 34.4 0.1 3.5 3 1 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 ELR22116.1 - 2.6e-05 23.8 0.1 0.0051 16.4 0.0 2.9 3 0 0 3 3 3 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 ELR22116.1 - 0.00024 20.9 0.4 0.87 9.5 0.1 3.1 2 1 1 3 3 3 2 Occluded RNA-recognition motif DUF4523 PF15023.6 ELR22116.1 - 0.015 15.1 0.0 0.075 12.8 0.0 2.1 2 1 1 3 3 3 0 Protein of unknown function (DUF4523) PHM7_cyt PF14703.6 ELR22116.1 - 0.041 14.1 3.8 0.56 10.4 0.1 3.0 3 1 0 3 3 3 0 Cytosolic domain of 10TM putative phosphate transporter Mucin PF01456.17 ELR22117.1 - 0.043 13.8 20.4 0.064 13.2 20.4 1.3 1 0 0 1 1 1 0 Mucin-like glycoprotein Atrophin-1 PF03154.15 ELR22117.1 - 0.11 10.8 12.2 0.13 10.6 12.2 1.0 1 0 0 1 1 1 0 Atrophin-1 family FAM199X PF15814.5 ELR22117.1 - 0.2 10.7 5.0 0.26 10.3 5.0 1.1 1 0 0 1 1 1 0 Protein family FAM199X Dicty_REP PF05086.12 ELR22117.1 - 1.2 7.1 8.2 1.4 6.8 8.2 1.0 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Menin PF05053.13 ELR22117.1 - 2.5 6.4 4.9 3.2 6.0 4.9 1.0 1 0 0 1 1 1 0 Menin MSP1_C PF07462.11 ELR22117.1 - 4 6.0 7.6 5.1 5.7 7.6 1.1 1 0 0 1 1 1 0 Merozoite surface protein 1 (MSP1) C-terminus SDA1 PF05285.12 ELR22118.1 - 0.00086 18.8 22.3 0.00091 18.7 22.3 1.1 1 0 0 1 1 1 1 SDA1 DUF3996 PF13161.6 ELR22118.1 - 0.18 11.5 0.1 0.33 10.7 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3996) U1snRNP70_N PF12220.8 ELR22118.1 - 0.19 12.4 7.4 1.8 9.2 7.0 2.3 2 0 0 2 2 2 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal Fmp27 PF10344.9 ELR22118.1 - 0.56 8.2 7.3 0.82 7.7 7.3 1.3 1 0 0 1 1 1 0 Mitochondrial protein from FMP27 Prothymosin PF03247.14 ELR22118.1 - 3.4 8.2 40.6 0.075 13.5 20.7 2.2 2 0 0 2 2 2 0 Prothymosin/parathymosin family Presenilin PF01080.17 ELR22118.1 - 5.7 5.6 8.1 7.3 5.2 8.1 1.1 1 0 0 1 1 1 0 Presenilin TFB6 PF17110.5 ELR22118.1 - 6.3 6.5 18.6 5.8 6.6 0.3 2.2 2 0 0 2 2 2 0 Subunit 11 of the general transcription factor TFIIH RNA_pol_3_Rpc31 PF11705.8 ELR22118.1 - 6.8 6.9 37.6 1.7 8.8 18.8 2.1 2 0 0 2 2 2 0 DNA-directed RNA polymerase III subunit Rpc31 SMI1_KNR4 PF09346.10 ELR22119.1 - 3e-06 27.7 0.0 7.6e-06 26.3 0.0 1.6 2 0 0 2 2 2 1 SMI1 / KNR4 family (SUKH-1) SUKH_5 PF14567.6 ELR22119.1 - 0.0042 16.8 0.0 0.0076 16.0 0.0 1.5 1 0 0 1 1 1 1 SMI1-KNR4 cell-wall GSP_synth PF03738.14 ELR22119.1 - 0.15 11.2 0.0 0.28 10.3 0.0 1.4 1 0 0 1 1 1 0 Glutathionylspermidine synthase preATP-grasp TPR_1 PF00515.28 ELR22120.1 - 0.0014 18.4 2.3 0.0026 17.5 2.3 1.5 1 0 0 1 1 1 1 Tetratricopeptide repeat MIT PF04212.18 ELR22120.1 - 0.0023 18.0 0.6 0.0043 17.1 0.6 1.4 1 0 0 1 1 1 1 MIT (microtubule interacting and transport) domain TPR_2 PF07719.17 ELR22120.1 - 0.012 15.6 2.0 0.012 15.6 2.0 2.1 2 0 0 2 2 2 0 Tetratricopeptide repeat Chordopox_A13L PF05961.11 ELR22120.1 - 0.022 15.0 0.0 0.044 14.0 0.0 1.5 1 0 0 1 1 1 0 Chordopoxvirus A13L protein TPR_7 PF13176.6 ELR22120.1 - 0.075 13.1 0.1 0.17 12.0 0.1 1.6 1 0 0 1 1 1 0 Tetratricopeptide repeat RB_A PF01858.17 ELR22120.1 - 0.083 12.7 0.1 0.13 12.0 0.1 1.2 1 0 0 1 1 1 0 Retinoblastoma-associated protein A domain TPR_12 PF13424.6 ELR22120.1 - 0.17 12.2 0.4 0.32 11.3 0.4 1.4 1 0 0 1 1 1 0 Tetratricopeptide repeat PhyH PF05721.13 ELR22121.1 - 2.6e-08 34.4 0.0 3.3e-05 24.2 0.0 2.3 2 0 0 2 2 2 2 Phytanoyl-CoA dioxygenase (PhyH) 2OG-FeII_Oxy_3 PF13640.6 ELR22121.1 - 0.037 14.9 0.0 0.081 13.8 0.0 1.5 1 0 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily PNK3P PF08645.11 ELR22122.1 - 1.1e-54 184.5 0.0 2.5e-54 183.3 0.0 1.6 1 0 0 1 1 1 1 Polynucleotide kinase 3 phosphatase AAA_33 PF13671.6 ELR22122.1 - 3e-15 56.6 0.0 1e-06 29.0 0.0 2.9 2 1 1 3 3 3 2 AAA domain zf-CCHH PF10283.9 ELR22122.1 - 1.1e-11 44.5 0.2 2.6e-11 43.3 0.2 1.6 1 0 0 1 1 1 1 PBZ domain KTI12 PF08433.10 ELR22122.1 - 4.5e-05 23.0 0.0 0.039 13.4 0.0 2.2 2 0 0 2 2 2 2 Chromatin associated protein KTI12 Zeta_toxin PF06414.12 ELR22122.1 - 0.007 15.7 0.0 0.33 10.2 0.0 2.3 2 0 0 2 2 2 1 Zeta toxin Hydrolase_6 PF13344.6 ELR22122.1 - 0.017 15.2 0.0 0.24 11.5 0.0 2.4 2 0 0 2 2 2 0 Haloacid dehalogenase-like hydrolase DUF3439 PF11921.8 ELR22122.1 - 0.12 12.3 0.9 0.26 11.2 0.9 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) SET PF00856.28 ELR22123.1 - 4.2e-18 66.3 0.0 1.8e-17 64.2 0.0 1.9 1 1 0 1 1 1 1 SET domain zf-MYND PF01753.18 ELR22123.1 - 0.00087 19.3 10.7 0.00087 19.3 10.7 2.2 2 0 0 2 2 2 1 MYND finger HypA PF01155.19 ELR22123.1 - 0.89 9.6 5.3 1.3 9.1 0.8 2.4 2 0 0 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zinc_ribbon_9 PF14369.6 ELR22123.1 - 8.4 6.8 12.4 1.2 9.4 1.3 3.3 3 0 0 3 3 3 0 zinc-ribbon Med9 PF07544.13 ELR22125.1 - 4e-10 39.6 0.1 5.1e-10 39.3 0.1 1.1 1 0 0 1 1 1 1 RNA polymerase II transcription mediator complex subunit 9 COMMD1_N PF17221.3 ELR22125.1 - 0.015 15.6 0.1 0.018 15.3 0.1 1.1 1 0 0 1 1 1 0 COMMD1 N-terminal domain DUF349 PF03993.12 ELR22125.1 - 0.12 12.7 1.6 0.24 11.7 1.6 1.6 1 1 0 1 1 1 0 Domain of Unknown Function (DUF349) MMR_HSR1 PF01926.23 ELR22126.1 - 1.2e-14 54.4 0.0 2.3e-14 53.5 0.0 1.5 2 0 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 ELR22126.1 - 1.3e-08 34.6 0.0 1.8e-08 34.1 0.0 1.2 1 0 0 1 1 1 1 Ferrous iron transport protein B MCM PF00493.23 ELR22126.1 - 0.077 12.1 0.0 0.082 12.0 0.0 1.2 1 0 0 1 1 1 0 MCM P-loop domain Dynamin_N PF00350.23 ELR22126.1 - 0.11 12.5 0.6 4.3 7.4 0.0 2.3 2 1 1 3 3 3 0 Dynamin family CAF1 PF04857.20 ELR22127.1 - 9e-23 80.9 0.1 1.1e-22 80.6 0.1 1.1 1 0 0 1 1 1 1 CAF1 family ribonuclease RNA_bind PF08675.11 ELR22127.1 - 0.057 13.5 0.2 0.12 12.5 0.2 1.6 1 1 0 1 1 1 0 RNA binding domain MMR_HSR1_Xtn PF16897.5 ELR22128.1 - 4.7e-32 110.2 1.6 4.9e-32 110.1 0.7 1.5 2 0 0 2 2 2 1 C-terminal region of MMR_HSR1 domain TGS PF02824.21 ELR22128.1 - 2.8e-21 75.3 0.0 4.2e-21 74.8 0.0 1.3 1 0 0 1 1 1 1 TGS domain Sel1 PF08238.12 ELR22130.1 - 3e-14 53.1 15.3 7.9e-05 23.2 0.0 3.6 4 0 0 4 4 4 3 Sel1 repeat TPR_12 PF13424.6 ELR22130.1 - 0.028 14.7 8.2 0.16 12.3 6.1 3.1 1 1 2 3 3 3 0 Tetratricopeptide repeat TPR_17 PF13431.6 ELR22130.1 - 0.17 12.3 4.5 2.1 8.9 0.6 3.3 2 1 1 3 3 3 0 Tetratricopeptide repeat Aminotran_3 PF00202.21 ELR22132.1 - 8e-70 235.5 0.0 2.4e-54 184.5 0.0 2.2 1 1 1 2 2 2 2 Aminotransferase class-III TAF4 PF05236.14 ELR22133.1 - 2.8 7.6 10.6 4.5 6.9 10.6 1.2 1 0 0 1 1 1 0 Transcription initiation factor TFIID component TAF4 family Proteasome PF00227.26 ELR22135.1 - 5.5e-32 110.8 0.0 6.6e-32 110.5 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit SIL1 PF16782.5 ELR22135.1 - 0.27 10.4 0.0 0.34 10.1 0.0 1.2 1 0 0 1 1 1 0 Nucleotide exchange factor SIL1 CWC25 PF12542.8 ELR22136.1 - 7.1e-18 65.4 2.6 7.1e-18 65.4 2.6 5.7 3 1 0 3 3 3 1 Pre-mRNA splicing factor Cir_N PF10197.9 ELR22136.1 - 1e-11 44.8 11.6 1e-11 44.8 11.6 8.9 9 2 1 10 10 10 2 N-terminal domain of CBF1 interacting co-repressor CIR BAR_3 PF16746.5 ELR22137.1 - 2.5e-07 30.6 3.4 3.3e-07 30.3 3.4 1.0 1 0 0 1 1 1 1 BAR domain of APPL family BAR PF03114.18 ELR22137.1 - 5.9e-06 26.1 7.0 7.4e-06 25.8 7.0 1.0 1 0 0 1 1 1 1 BAR domain GGDEF_2 PF17853.1 ELR22137.1 - 0.00028 21.1 0.1 0.01 16.0 0.0 2.2 2 0 0 2 2 2 1 GGDEF-like domain CCDC74_C PF14917.6 ELR22137.1 - 0.56 10.7 5.9 0.31 11.6 3.8 1.5 2 0 0 2 2 2 0 Coiled coil protein 74, C terminal Porph_ging PF09697.10 ELR22137.1 - 1.2 9.7 3.6 0.88 10.2 1.7 1.7 2 0 0 2 2 2 0 Protein of unknown function (Porph_ging) MORN PF02493.20 ELR22138.1 - 2e-41 137.5 47.3 1.7e-09 37.0 3.1 7.3 7 0 0 7 7 7 6 MORN repeat nos_propeller_2 PF18793.1 ELR22138.1 - 0.054 13.8 0.2 18 5.7 0.0 3.2 2 1 1 3 3 3 0 Nitrous oxide reductase propeller repeat 2 DUF4113 PF13438.6 ELR22138.1 - 0.41 10.8 1.6 35 4.6 0.1 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4113) DUF3048_C PF17479.2 ELR22138.1 - 0.42 11.0 13.5 0.73 10.2 1.6 3.3 1 1 2 3 3 3 0 Protein of unknown function (DUF3048) C-terminal domain Ank_2 PF12796.7 ELR22139.1 - 2.2e-28 98.6 3.7 7.1e-11 42.5 0.1 3.9 2 2 2 4 4 4 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ELR22139.1 - 3.9e-21 75.1 4.9 1e-06 29.1 0.0 6.6 5 1 2 7 7 7 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 ELR22139.1 - 2.4e-17 61.2 12.1 0.0047 17.3 0.1 8.6 6 2 2 8 8 8 4 Ankyrin repeat Ank PF00023.30 ELR22139.1 - 3.1e-12 46.4 15.3 0.011 16.2 0.1 8.0 6 2 2 8 8 8 3 Ankyrin repeat Ank_5 PF13857.6 ELR22139.1 - 3.4e-12 46.3 12.6 0.0046 17.2 0.2 7.2 3 2 3 7 7 7 4 Ankyrin repeats (many copies) F-box-like PF12937.7 ELR22139.1 - 1.2e-11 44.4 0.5 2.7e-11 43.2 0.5 1.7 1 0 0 1 1 1 1 F-box-like RR_TM4-6 PF06459.12 ELR22139.1 - 0.0036 17.2 17.2 0.0053 16.6 17.2 1.1 1 0 0 1 1 1 1 Ryanodine Receptor TM 4-6 F-box PF00646.33 ELR22139.1 - 0.015 15.2 0.1 0.036 14.0 0.1 1.7 1 0 0 1 1 1 0 F-box domain F-box_5 PF18511.1 ELR22139.1 - 0.022 14.4 0.1 0.037 13.6 0.1 1.4 1 0 0 1 1 1 0 F-box Zip PF02535.22 ELR22139.1 - 0.45 9.7 6.6 0.65 9.1 6.6 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Vfa1 PF08432.10 ELR22139.1 - 0.65 10.3 18.9 1 9.7 18.9 1.3 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 CDC45 PF02724.14 ELR22139.1 - 0.96 7.7 12.9 1.3 7.2 12.9 1.1 1 0 0 1 1 1 0 CDC45-like protein FAM176 PF14851.6 ELR22139.1 - 1 9.0 9.0 1.9 8.2 9.0 1.4 1 0 0 1 1 1 0 FAM176 family DDHD PF02862.17 ELR22139.1 - 1 9.5 5.4 1.8 8.7 5.4 1.4 1 0 0 1 1 1 0 DDHD domain GAGA_bind PF06217.12 ELR22139.1 - 1.2 9.4 11.4 1.7 8.8 11.4 1.2 1 0 0 1 1 1 0 GAGA binding protein-like family SID-1_RNA_chan PF13965.6 ELR22139.1 - 3.1 6.1 6.1 4.3 5.6 6.1 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 ALMT PF11744.8 ELR22139.1 - 4.4 6.0 9.4 6 5.6 9.4 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter DUF3827 PF12877.7 ELR22139.1 - 4.7 5.5 13.2 6.4 5.0 13.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3827) CSRNP_N PF16019.5 ELR22139.1 - 5.3 6.9 11.6 8.7 6.2 11.6 1.3 1 0 0 1 1 1 0 Cysteine/serine-rich nuclear protein N-terminus TRAP_alpha PF03896.16 ELR22139.1 - 6.2 5.9 8.9 9.1 5.4 8.9 1.1 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit DUF913 PF06025.12 ELR22139.1 - 6.9 5.5 11.4 11 4.8 11.4 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Neur_chan_memb PF02932.16 ELR22139.1 - 7.7 6.5 7.4 12 5.9 7.4 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF2052 PF09747.9 ELR22139.1 - 8 6.5 17.7 13 5.9 17.7 1.2 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) Presenilin PF01080.17 ELR22139.1 - 8.4 5.0 14.0 12 4.5 14.0 1.1 1 0 0 1 1 1 0 Presenilin ANAPC10 PF03256.16 ELR22140.1 - 1.4e-63 213.9 0.0 2e-63 213.4 0.0 1.2 1 0 0 1 1 1 1 Anaphase-promoting complex, subunit 10 (APC10) Mito_carr PF00153.27 ELR22140.1 - 0.01 15.7 0.2 0.13 12.2 0.0 2.5 3 0 0 3 3 3 0 Mitochondrial carrier protein F5_F8_type_C PF00754.25 ELR22140.1 - 0.067 13.3 0.0 0.12 12.5 0.0 1.4 1 0 0 1 1 1 0 F5/8 type C domain Mito_carr PF00153.27 ELR22141.1 - 4.6e-07 29.7 0.3 7.1e-06 25.9 0.2 2.7 3 1 0 3 3 3 1 Mitochondrial carrier protein PrgI PF12666.7 ELR22141.1 - 0.1 13.3 0.7 17 6.2 0.0 2.7 2 1 0 2 2 2 0 PrgI family protein Nmad3 PF18754.1 ELR22144.1 - 0.014 15.0 0.0 0.029 14.0 0.0 1.4 1 0 0 1 1 1 0 Nucleotide modification associated domain 3 CAF1 PF04857.20 ELR22146.1 - 1.9e-83 280.3 0.0 2.2e-83 280.1 0.0 1.1 1 0 0 1 1 1 1 CAF1 family ribonuclease Pkinase PF00069.25 ELR22147.1 - 1.9e-05 24.1 0.3 2.8e-05 23.6 0.3 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR22147.1 - 0.0003 20.2 0.5 0.00038 19.8 0.5 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase CBM49 PF09478.10 ELR22148.1 - 9.3e-33 112.4 4.6 8.8e-18 64.4 0.5 3.1 3 0 0 3 3 3 3 Carbohydrate binding domain CBM49 CBM_2 PF00553.19 ELR22148.1 - 2.3e-15 56.7 19.2 1.7e-06 28.2 4.0 3.4 3 0 0 3 3 3 3 Cellulose binding domain DUF4352 PF11611.8 ELR22148.1 - 0.027 14.8 0.1 1.4 9.2 0.0 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4352) DUF4354 PF14263.6 ELR22148.1 - 0.045 13.6 0.1 0.82 9.5 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4354) Ald_Xan_dh_C2 PF02738.18 ELR22149.1 - 3e-130 435.3 0.0 3.6e-130 435.0 0.0 1.1 1 0 0 1 1 1 1 Molybdopterin-binding domain of aldehyde dehydrogenase Fer2_2 PF01799.20 ELR22150.1 - 3.9e-29 100.5 0.0 4.5e-29 100.3 0.0 1.0 1 0 0 1 1 1 1 [2Fe-2S] binding domain DUF758 PF05527.11 ELR22151.1 - 1.3e-09 38.3 0.1 2e-09 37.7 0.1 1.3 1 1 0 1 1 1 1 Domain of unknown function (DUF758) ADH_zinc_N_2 PF13602.6 ELR22152.1 - 6.2e-11 43.5 0.0 6.2e-11 43.5 0.0 1.4 2 0 0 2 2 2 1 Zinc-binding dehydrogenase Pkinase_Tyr PF07714.17 ELR22153.1 - 1.2e-94 316.4 0.0 5.9e-50 170.0 0.0 4.3 2 2 1 3 3 3 3 Protein tyrosine kinase Pkinase PF00069.25 ELR22153.1 - 3.4e-82 275.8 0.0 5.1e-44 150.6 0.0 3.9 3 1 0 3 3 3 3 Protein kinase domain 5_nucleotid_C PF02872.18 ELR22153.1 - 6.3e-28 98.0 0.0 1.5e-27 96.8 0.0 1.6 1 0 0 1 1 1 1 5'-nucleotidase, C-terminal domain Haspin_kinase PF12330.8 ELR22153.1 - 1.4e-05 24.2 0.3 0.043 12.8 0.0 3.1 3 0 0 3 3 3 2 Haspin like kinase domain Kinase-like PF14531.6 ELR22153.1 - 6.6e-05 22.4 0.0 0.07 12.4 0.0 2.3 2 0 0 2 2 2 2 Kinase-like APH PF01636.23 ELR22153.1 - 0.00024 21.1 2.8 0.091 12.7 0.5 3.2 2 2 1 3 3 3 2 Phosphotransferase enzyme family Guanylate_cyc PF00211.20 ELR22153.1 - 0.00033 20.3 0.0 0.24 11.0 0.0 2.3 1 1 1 2 2 2 2 Adenylate and Guanylate cyclase catalytic domain EGF_2 PF07974.13 ELR22153.1 - 0.0031 17.8 8.8 0.009 16.4 8.8 1.9 1 0 0 1 1 1 1 EGF-like domain Pkinase_fungal PF17667.1 ELR22153.1 - 0.045 12.5 0.1 5.4 5.7 0.0 2.2 2 0 0 2 2 2 0 Fungal protein kinase IBN_N PF03810.19 ELR22154.1 - 0.0027 17.6 0.1 0.031 14.2 0.0 2.9 2 1 0 2 2 2 1 Importin-beta N-terminal domain DAO_C PF16901.5 ELR22155.1 - 7.8e-45 151.8 0.2 3.8e-44 149.6 0.2 2.1 2 0 0 2 2 2 1 C-terminal domain of alpha-glycerophosphate oxidase DAO PF01266.24 ELR22155.1 - 1.1e-43 150.2 0.2 9.4e-43 147.1 0.2 2.0 1 1 0 1 1 1 1 FAD dependent oxidoreductase EF-hand_7 PF13499.6 ELR22155.1 - 1.4e-12 47.9 3.0 3.4e-12 46.6 3.0 1.7 1 0 0 1 1 1 1 EF-hand domain pair FAD_binding_2 PF00890.24 ELR22155.1 - 1.2e-09 37.8 0.8 0.00016 20.9 0.1 2.2 2 0 0 2 2 2 2 FAD binding domain EF-hand_1 PF00036.32 ELR22155.1 - 6.1e-09 34.8 1.5 0.00023 20.5 0.6 2.7 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 ELR22155.1 - 2e-06 27.2 1.1 0.08 12.9 0.2 2.6 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.6 ELR22155.1 - 2.2e-06 27.4 1.7 4.6e-06 26.4 1.0 2.0 1 1 1 2 2 2 1 EF-hand domain pair EF-hand_5 PF13202.6 ELR22155.1 - 7.6e-06 25.2 1.2 0.011 15.2 0.6 2.5 2 0 0 2 2 2 2 EF hand FAD_oxidored PF12831.7 ELR22155.1 - 4.5e-05 23.0 1.3 9.8e-05 21.9 1.3 1.6 1 1 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 ELR22155.1 - 0.0016 17.7 0.2 0.0042 16.4 0.2 1.7 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 ELR22155.1 - 0.011 15.0 0.1 0.047 12.9 0.1 2.0 1 1 0 1 1 1 0 FAD binding domain GIDA PF01134.22 ELR22155.1 - 0.013 14.6 0.6 0.33 10.0 0.1 2.2 2 0 0 2 2 2 0 Glucose inhibited division protein A NAD_binding_8 PF13450.6 ELR22155.1 - 0.026 14.8 0.2 0.061 13.6 0.2 1.6 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain 3HCDH_N PF02737.18 ELR22155.1 - 0.071 13.0 0.0 0.17 11.8 0.0 1.7 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain HI0933_like PF03486.14 ELR22155.1 - 0.15 10.7 0.2 0.32 9.7 0.2 1.5 1 0 0 1 1 1 0 HI0933-like protein MIP PF00230.20 ELR22156.1 - 4.8e-37 127.9 12.7 6.5e-37 127.4 12.7 1.2 1 0 0 1 1 1 1 Major intrinsic protein Mitovir_RNA_pol PF05919.11 ELR22156.1 - 0.026 13.7 1.5 0.04 13.1 1.5 1.2 1 0 0 1 1 1 0 Mitovirus RNA-dependent RNA polymerase ArfGap PF01412.18 ELR22157.1 - 7.4e-07 29.3 0.1 1.6e-06 28.2 0.1 1.6 2 0 0 2 2 2 1 Putative GTPase activating protein for Arf Y_phosphatase3 PF13350.6 ELR22158.1 - 7.2e-42 143.9 0.0 1.5e-41 142.9 0.0 1.5 1 1 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase2 PF03162.13 ELR22158.1 - 3.6e-06 26.7 0.0 9.5e-06 25.3 0.0 1.7 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase PF00102.27 ELR22158.1 - 0.0034 17.0 0.0 0.0053 16.3 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Myotub-related PF06602.14 ELR22158.1 - 0.011 14.7 0.1 0.018 14.0 0.1 1.2 1 0 0 1 1 1 0 Myotubularin-like phosphatase domain Amidase PF01425.21 ELR22159.1 - 7.3e-130 433.9 1.0 8.7e-130 433.7 0.0 1.6 2 0 0 2 2 2 1 Amidase Pyridoxal_deC PF00282.19 ELR22160.1 - 1.1e-77 261.3 0.0 1.3e-77 261.0 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain FBA PF04300.13 ELR22161.1 - 1.1e-09 38.3 0.0 2.2e-09 37.3 0.0 1.4 1 0 0 1 1 1 1 F-box associated region Lactamase_B PF00753.27 ELR22162.1 - 9.1e-07 29.1 0.1 1.3e-06 28.6 0.1 1.2 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_4 PF13691.6 ELR22162.1 - 0.0079 15.9 0.0 0.011 15.4 0.0 1.2 1 0 0 1 1 1 1 tRNase Z endonuclease Lactamase_B_2 PF12706.7 ELR22162.1 - 0.008 15.7 0.1 0.011 15.2 0.1 1.2 1 0 0 1 1 1 1 Beta-lactamase superfamily domain PUCC PF03209.15 ELR22163.1 - 0.00022 20.4 0.5 0.00025 20.2 0.5 1.0 1 0 0 1 1 1 1 PUCC protein MFS_1 PF07690.16 ELR22163.1 - 0.00022 20.3 0.1 0.00024 20.1 0.1 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily Mucin PF01456.17 ELR22164.1 - 0.00023 21.2 7.7 0.00027 20.9 7.7 1.2 1 0 0 1 1 1 1 Mucin-like glycoprotein FAM176 PF14851.6 ELR22164.1 - 0.019 14.7 0.0 0.027 14.1 0.0 1.2 1 0 0 1 1 1 0 FAM176 family FSA_C PF10479.9 ELR22164.1 - 0.37 8.9 3.9 0.42 8.7 3.9 1.0 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus Pex14_N PF04695.13 ELR22164.1 - 5.4 7.7 11.2 1.1 9.9 5.6 2.3 3 0 0 3 3 3 0 Peroxisomal membrane anchor protein (Pex14p) conserved region PIP5K PF01504.18 ELR22165.1 - 3.9e-63 213.3 0.4 8.2e-63 212.2 0.0 1.7 2 1 0 2 2 2 1 Phosphatidylinositol-4-phosphate 5-Kinase Tox-ART-HYD1 PF15633.6 ELR22165.1 - 0.037 14.7 0.1 0.62 10.8 0.0 2.4 2 0 0 2 2 2 0 HYD1 signature containing ADP-ribosyltransferase TMCO5 PF14992.6 ELR22165.1 - 0.26 10.8 2.8 0.39 10.2 2.8 1.2 1 0 0 1 1 1 0 TMCO5 family Abhydrolase_6 PF12697.7 ELR22166.1 - 5.8e-12 46.7 4.4 1.4e-11 45.4 4.4 1.6 1 1 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 ELR22166.1 - 8.8e-08 31.7 0.6 1.5e-07 30.9 0.6 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 ELR22166.1 - 8.9e-08 32.1 0.1 3.4e-07 30.2 0.1 1.8 2 0 0 2 2 2 1 alpha/beta hydrolase fold Ser_hydrolase PF06821.13 ELR22166.1 - 0.019 14.9 0.1 0.046 13.6 0.1 1.6 1 0 0 1 1 1 0 Serine hydrolase EGF_2 PF07974.13 ELR22167.1 - 6.7e-07 29.6 10.7 1.1e-06 28.9 10.7 1.4 1 0 0 1 1 1 1 EGF-like domain EGF PF00008.27 ELR22167.1 - 0.0001 22.5 5.7 0.0002 21.6 5.7 1.5 1 0 0 1 1 1 1 EGF-like domain Amnionless PF14828.6 ELR22167.1 - 0.0034 16.3 0.6 0.0034 16.3 0.6 1.4 1 1 0 1 1 1 1 Amnionless hEGF PF12661.7 ELR22167.1 - 0.0064 17.1 3.9 0.0064 17.1 3.9 1.8 2 0 0 2 2 2 1 Human growth factor-like EGF G8 PF10162.9 ELR22167.1 - 0.036 14.2 0.0 0.041 14.0 0.0 1.2 1 0 0 1 1 1 0 G8 domain SH3_1 PF00018.28 ELR22168.1 - 2.7e-12 46.1 0.1 4.1e-12 45.5 0.1 1.3 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 ELR22168.1 - 3.5e-12 46.0 0.0 5.2e-12 45.4 0.0 1.3 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 ELR22168.1 - 1.1e-10 41.1 0.0 1.6e-10 40.5 0.0 1.3 1 0 0 1 1 1 1 Variant SH3 domain HA2 PF04408.23 ELR22169.1 - 2.5e-27 95.3 1.9 5.1e-27 94.3 0.1 2.4 2 0 0 2 2 2 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 ELR22169.1 - 5.7e-26 90.7 0.0 1.4e-25 89.5 0.0 1.7 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 ELR22169.1 - 3e-12 46.9 0.0 6.7e-12 45.7 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain S1 PF00575.23 ELR22169.1 - 3.1e-07 30.6 1.1 7e-07 29.5 1.1 1.6 1 0 0 1 1 1 1 S1 RNA binding domain DEAD PF00270.29 ELR22169.1 - 5.8e-06 26.2 0.0 1.4e-05 25.0 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 ELR22169.1 - 2.1e-05 24.8 0.0 6.2e-05 23.3 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 ELR22169.1 - 0.0005 19.9 0.0 0.0012 18.5 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 ELR22169.1 - 0.019 15.3 0.0 0.036 14.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain T2SSE PF00437.20 ELR22169.1 - 0.027 13.5 0.0 0.064 12.3 0.0 1.5 1 0 0 1 1 1 0 Type II/IV secretion system protein PhoH PF02562.16 ELR22169.1 - 0.12 11.8 0.0 0.29 10.5 0.0 1.6 1 0 0 1 1 1 0 PhoH-like protein Microtub_bd PF16796.5 ELR22169.1 - 0.17 11.8 0.0 3.9 7.4 0.0 2.4 2 0 0 2 2 2 0 Microtubule binding zf-CCHH PF10283.9 ELR22170.1 - 1.5e-11 44.0 4.6 2.6e-11 43.3 4.6 1.4 1 0 0 1 1 1 1 PBZ domain FHA PF00498.26 ELR22170.1 - 4e-05 23.9 0.0 9.3e-05 22.7 0.0 1.6 1 0 0 1 1 1 1 FHA domain FixH PF05751.11 ELR22170.1 - 0.28 11.2 1.9 0.65 10.0 0.2 2.3 3 0 0 3 3 3 0 FixH RVT_2 PF07727.14 ELR22172.1 - 9.4e-05 22.2 0.1 0.00012 21.8 0.1 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Beta-TrCP_D PF12125.8 ELR22172.1 - 0.047 13.6 1.3 0.11 12.4 1.3 1.6 1 0 0 1 1 1 0 D domain of beta-TrCP gag_pre-integrs PF13976.6 ELR22173.1 - 0.0062 16.4 0.3 0.018 14.9 0.3 1.8 1 0 0 1 1 1 1 GAG-pre-integrase domain CD36 PF01130.21 ELR22174.1 - 2.5e-67 227.4 0.2 6e-43 147.0 0.0 2.2 2 0 0 2 2 2 2 CD36 family HA PF03457.14 ELR22175.1 - 3.1e-16 59.5 0.5 1.3e-15 57.5 0.5 2.2 1 0 0 1 1 1 1 Helicase associated domain RR_TM4-6 PF06459.12 ELR22176.1 - 0.051 13.4 16.0 0.061 13.2 16.0 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF755 PF05501.11 ELR22176.1 - 1 9.7 31.3 1.6 9.0 31.3 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF755) GAGA_bind PF06217.12 ELR22176.1 - 1.1 9.5 16.7 1.1 9.4 16.7 1.1 1 0 0 1 1 1 0 GAGA binding protein-like family Vfa1 PF08432.10 ELR22176.1 - 1.5 9.1 25.5 2 8.7 25.5 1.3 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 EOS1 PF12326.8 ELR22176.1 - 2 8.3 4.7 2.4 8.1 4.7 1.3 1 0 0 1 1 1 0 N-glycosylation protein LCD1 PF09798.9 ELR22176.1 - 3.4 6.1 16.6 3.1 6.2 16.6 1.0 1 0 0 1 1 1 0 DNA damage checkpoint protein AAA_11 PF13086.6 ELR22176.1 - 3.7 7.3 14.2 4.5 7.0 14.2 1.1 1 0 0 1 1 1 0 AAA domain DDHD PF02862.17 ELR22176.1 - 6 7.0 11.0 7 6.7 11.0 1.2 1 0 0 1 1 1 0 DDHD domain BTB PF00651.31 ELR22177.1 - 5.7e-27 94.1 1.7 3.2e-25 88.5 0.3 2.8 2 1 1 3 3 3 1 BTB/POZ domain Filamin PF00630.19 ELR22177.1 - 1.7e-23 83.4 0.0 7e-14 52.5 0.0 4.0 2 1 1 3 3 3 3 Filamin/ABP280 repeat RCC1 PF00415.18 ELR22177.1 - 1.7e-18 66.9 2.9 1.8e-06 28.5 0.0 6.5 6 0 0 6 6 6 3 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 ELR22177.1 - 1e-08 34.7 11.6 8.6e-06 25.4 0.0 6.0 7 0 0 7 7 7 2 Regulator of chromosome condensation (RCC1) repeat Gal_Lectin PF02140.18 ELR22177.1 - 9.3e-08 32.4 0.1 2.7e-07 30.9 0.1 1.8 1 0 0 1 1 1 1 Galactose binding lectin domain Invasin_D3 PF09134.10 ELR22177.1 - 0.00027 21.2 0.1 0.0016 18.7 0.1 2.4 1 0 0 1 1 1 1 Invasin, domain 3 BTB PF00651.31 ELR22178.1 - 5.5e-29 100.6 0.0 3e-20 72.5 0.0 3.2 2 1 1 3 3 3 2 BTB/POZ domain RCC1 PF00415.18 ELR22178.1 - 7.6e-29 100.1 8.2 1.7e-12 47.8 0.3 6.5 6 1 0 6 6 6 3 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 ELR22178.1 - 5.6e-14 51.5 24.6 1.1e-06 28.3 0.2 6.1 6 0 0 6 6 6 4 Regulator of chromosome condensation (RCC1) repeat Filamin PF00630.19 ELR22178.1 - 4e-09 37.2 0.0 1.2e-08 35.7 0.0 1.8 2 0 0 2 2 2 1 Filamin/ABP280 repeat DUF1874 PF08960.10 ELR22178.1 - 0.0051 16.9 0.0 0.011 15.8 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1874) Hira PF07569.11 ELR22178.1 - 0.036 13.8 3.2 6.8 6.3 0.0 3.4 3 1 1 4 4 4 0 TUP1-like enhancer of split Nop PF01798.18 ELR22178.1 - 0.12 11.8 0.0 0.22 11.0 0.0 1.3 1 0 0 1 1 1 0 snoRNA binding domain, fibrillarin RFX_DNA_binding PF02257.15 ELR22179.1 - 7.7e-14 52.1 0.9 1.5e-13 51.1 0.0 1.9 2 0 0 2 2 2 1 RFX DNA-binding domain Cdc6_C PF09079.11 ELR22179.1 - 0.028 14.4 0.0 0.048 13.6 0.0 1.4 1 0 0 1 1 1 0 CDC6, C terminal winged helix domain Pox_D5 PF03288.16 ELR22179.1 - 0.033 14.7 0.0 0.057 13.9 0.0 1.4 1 0 0 1 1 1 0 Poxvirus D5 protein-like Ank_2 PF12796.7 ELR22180.1 - 8.1e-41 138.5 0.0 2e-20 73.2 0.3 5.1 2 1 3 5 5 5 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ELR22180.1 - 6.1e-35 119.2 0.0 1.7e-09 38.0 0.0 5.4 3 1 1 5 5 5 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 ELR22180.1 - 1.1e-34 114.5 0.3 1.5e-05 25.0 0.0 8.6 9 0 0 9 9 9 5 Ankyrin repeat Ank PF00023.30 ELR22180.1 - 1.6e-30 104.2 2.5 4.5e-06 26.9 0.0 7.9 9 0 0 9 9 9 5 Ankyrin repeat Ank_5 PF13857.6 ELR22180.1 - 8e-25 86.6 2.1 1.4e-07 31.6 0.2 6.2 2 1 4 6 6 6 6 Ankyrin repeats (many copies) Imm_superinfect PF14373.6 ELR22180.1 - 0.013 15.4 0.2 14 5.7 0.0 3.9 4 0 0 4 4 4 0 Superinfection immunity protein LMBR1 PF04791.16 ELR22180.1 - 0.12 11.3 0.6 0.19 10.6 0.6 1.3 1 0 0 1 1 1 0 LMBR1-like membrane protein CAP PF00188.26 ELR22181.1 - 1.9e-08 35.2 0.9 2.6e-08 34.8 0.9 1.2 1 0 0 1 1 1 1 Cysteine-rich secretory protein family FYVE PF01363.21 ELR22182.1 - 5e-12 45.8 7.8 9.9e-12 44.8 7.8 1.5 1 0 0 1 1 1 1 FYVE zinc finger FYVE_2 PF02318.16 ELR22182.1 - 0.044 14.0 3.0 0.09 13.0 3.0 1.5 1 0 0 1 1 1 0 FYVE-type zinc finger zf-B_box PF00643.24 ELR22182.1 - 2.2 8.5 7.1 0.99 9.6 3.9 1.9 2 0 0 2 2 2 0 B-box zinc finger CDC45 PF02724.14 ELR22182.1 - 6.6 4.9 15.5 13 3.9 15.5 1.4 1 0 0 1 1 1 0 CDC45-like protein Glutaredoxin PF00462.24 ELR22183.1 - 3.4e-18 65.6 0.0 6.1e-18 64.8 0.0 1.4 1 0 0 1 1 1 1 Glutaredoxin TTL PF03133.15 ELR22185.1 - 2.9e-23 82.4 0.5 2e-22 79.7 0.2 2.1 1 1 1 2 2 2 1 Tubulin-tyrosine ligase family GTP_EFTU PF00009.27 ELR22186.1 - 5.8e-40 136.9 0.0 8.7e-40 136.3 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 ELR22186.1 - 7.3e-25 87.5 0.8 2.4e-23 82.6 0.2 2.6 2 0 0 2 2 2 1 Elongation factor Tu C-terminal domain MMR_HSR1 PF01926.23 ELR22186.1 - 8.3e-08 32.3 0.0 1.5e-06 28.2 0.0 2.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 ELR22186.1 - 0.00013 21.5 0.1 0.0049 16.4 0.1 3.0 3 1 0 3 3 3 1 Ferrous iron transport protein B cobW PF02492.19 ELR22186.1 - 0.0059 16.2 1.9 0.23 11.0 0.0 3.1 3 0 0 3 3 3 1 CobW/HypB/UreG, nucleotide-binding domain GTP_EFTU_D2 PF03144.25 ELR22186.1 - 0.0063 16.9 0.2 0.015 15.7 0.2 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 2 Dynamin_N PF00350.23 ELR22186.1 - 0.06 13.4 0.0 4.2 7.4 0.0 2.3 1 1 1 2 2 2 0 Dynamin family ATP_bind_1 PF03029.17 ELR22186.1 - 0.069 12.9 0.1 6.5 6.5 0.0 2.4 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein GTP_EFTU_D4 PF14578.6 ELR22186.1 - 0.071 13.0 0.3 0.15 11.9 0.3 1.5 1 0 0 1 1 1 0 Elongation factor Tu domain 4 Ras PF00071.22 ELR22187.1 - 8.8e-43 145.7 0.1 1.1e-42 145.4 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR22187.1 - 9.2e-29 100.1 0.1 1.5e-28 99.4 0.1 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR22187.1 - 6.6e-10 38.7 0.1 8.6e-10 38.3 0.1 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 ELR22187.1 - 5.2e-08 32.5 0.1 6.3e-08 32.3 0.1 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region DLIC PF05783.11 ELR22187.1 - 1.3e-05 24.3 0.4 0.046 12.5 0.0 2.1 1 1 1 2 2 2 2 Dynein light intermediate chain (DLIC) MMR_HSR1 PF01926.23 ELR22187.1 - 0.00026 21.0 0.3 0.00048 20.2 0.1 1.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase PduV-EutP PF10662.9 ELR22187.1 - 0.00055 19.7 0.1 0.0057 16.4 0.0 2.2 2 1 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation AAA_7 PF12775.7 ELR22187.1 - 0.0011 18.5 0.0 0.0018 17.8 0.0 1.3 1 0 0 1 1 1 1 P-loop containing dynein motor region GTP_EFTU PF00009.27 ELR22187.1 - 0.002 17.7 1.4 0.045 13.3 0.1 2.3 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain DUF4940 PF16298.5 ELR22187.1 - 0.009 15.7 0.2 0.14 11.8 0.1 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF4940) G-alpha PF00503.20 ELR22187.1 - 0.014 14.6 0.5 0.19 10.8 0.1 2.0 1 1 0 2 2 2 0 G-protein alpha subunit TniB PF05621.11 ELR22187.1 - 0.014 14.8 0.0 0.13 11.7 0.1 2.1 1 1 1 2 2 2 0 Bacterial TniB protein ATP_bind_1 PF03029.17 ELR22187.1 - 0.016 15.0 0.1 1.8 8.3 0.0 2.2 1 1 1 2 2 2 0 Conserved hypothetical ATP binding protein SRPRB PF09439.10 ELR22187.1 - 0.071 12.5 0.4 0.15 11.5 0.0 1.7 2 0 0 2 2 2 0 Signal recognition particle receptor beta subunit cobW PF02492.19 ELR22187.1 - 0.077 12.6 0.1 3.7 7.1 0.0 2.4 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Sigma54_activat PF00158.26 ELR22187.1 - 0.1 12.3 0.0 0.15 11.7 0.0 1.3 1 0 0 1 1 1 0 Sigma-54 interaction domain TsaE PF02367.17 ELR22187.1 - 0.11 12.5 0.0 0.28 11.2 0.0 1.7 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_16 PF13191.6 ELR22187.1 - 0.11 12.9 0.0 0.21 11.9 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain AAA_22 PF13401.6 ELR22187.1 - 0.11 12.8 0.0 0.19 12.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA PF00004.29 ELR22187.1 - 0.15 12.5 0.0 0.25 11.7 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Surface_antigen PF11054.8 ELR22187.1 - 0.16 11.7 0.0 0.25 11.0 0.0 1.2 1 0 0 1 1 1 0 Sporozoite TA4 surface antigen PIP5K PF01504.18 ELR22188.1 - 3.6e-71 239.6 1.0 3.6e-71 239.6 1.0 2.2 2 0 0 2 2 2 1 Phosphatidylinositol-4-phosphate 5-Kinase Zip PF02535.22 ELR22188.1 - 0.007 15.6 21.0 0.042 13.1 8.1 2.1 2 0 0 2 2 2 2 ZIP Zinc transporter Coilin_N PF15862.5 ELR22188.1 - 0.0083 15.9 5.4 0.0083 15.9 5.4 3.1 2 1 0 2 2 1 1 Coilin N-terminus DUF4471 PF14740.6 ELR22188.1 - 0.0088 15.3 0.3 0.0088 15.3 0.3 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF4471) EPL1 PF10513.9 ELR22188.1 - 0.079 13.3 13.5 1.3 9.4 0.6 2.2 2 0 0 2 2 2 0 Enhancer of polycomb-like Pox_Ag35 PF03286.14 ELR22188.1 - 0.088 12.6 23.5 0.2 11.4 13.1 2.2 2 0 0 2 2 2 0 Pox virus Ag35 surface protein CDC45 PF02724.14 ELR22188.1 - 0.15 10.3 15.9 0.68 8.2 1.2 2.1 2 0 0 2 2 2 0 CDC45-like protein AIF_C PF14721.6 ELR22188.1 - 0.29 11.5 10.6 1.3 9.3 0.7 2.5 2 0 0 2 2 2 0 Apoptosis-inducing factor, mitochondrion-associated, C-term RR_TM4-6 PF06459.12 ELR22188.1 - 0.35 10.7 19.9 0.24 11.2 0.5 2.3 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 TCP PF03634.13 ELR22188.1 - 0.49 11.0 16.7 3.1 8.3 7.3 2.2 2 0 0 2 2 2 0 TCP family transcription factor Presenilin PF01080.17 ELR22188.1 - 0.61 8.8 13.6 1.8 7.3 0.1 2.1 2 0 0 2 2 2 0 Presenilin SpoIIIAH PF12685.7 ELR22188.1 - 0.68 9.7 10.5 2.4 7.9 0.2 2.3 2 0 0 2 2 2 0 SpoIIIAH-like protein GCIP PF13324.6 ELR22188.1 - 0.79 9.3 5.3 7.9 6.0 1.8 2.5 3 0 0 3 3 3 0 Grap2 and cyclin-D-interacting Rtf2 PF04641.12 ELR22188.1 - 1.2 8.5 22.8 0.59 9.5 2.2 2.2 2 0 0 2 2 2 0 Rtf2 RING-finger Connexin PF00029.19 ELR22188.1 - 1.6 8.5 16.2 0.26 11.0 1.5 2.4 2 0 0 2 2 2 0 Connexin AF-4 PF05110.13 ELR22188.1 - 2 6.4 23.3 0.58 8.2 4.8 2.1 2 0 0 2 2 2 0 AF-4 proto-oncoprotein Pox_P35 PF03213.14 ELR22188.1 - 2.6 7.2 7.9 0.1 11.8 1.3 1.9 2 0 0 2 2 2 0 Poxvirus P35 protein Membralin PF09746.9 ELR22188.1 - 2.9 6.8 7.9 0.73 8.8 1.6 2.0 2 0 0 2 2 2 0 Tumour-associated protein SMYLE_N PF18615.1 ELR22188.1 - 2.9 7.4 10.4 0.24 10.9 3.4 2.0 2 0 0 2 2 2 0 Short myomegalin-like EB1 binding proteins, N-terminal domain SLC12 PF03522.15 ELR22188.1 - 3.3 6.6 13.5 3.1 6.7 0.3 2.1 2 0 0 2 2 2 0 Solute carrier family 12 BORG_CEP PF14957.6 ELR22188.1 - 4.2 8.5 13.0 16 6.7 0.2 2.3 2 0 0 2 2 2 0 Cdc42 effector Gti1_Pac2 PF09729.9 ELR22188.1 - 5.3 7.1 18.3 2.9 8.0 0.7 2.4 2 0 0 2 2 2 0 Gti1/Pac2 family CSRNP_N PF16019.5 ELR22188.1 - 5.8 6.8 12.7 0.39 10.6 0.8 2.4 2 0 0 2 2 2 0 Cysteine/serine-rich nuclear protein N-terminus RP-C_C PF11800.8 ELR22188.1 - 7.7 6.6 10.5 11 6.1 0.2 2.3 2 0 0 2 2 2 0 Replication protein C C-terminal region FAM76 PF16046.5 ELR22188.1 - 9.9 5.4 27.5 0.2 11.0 3.9 2.1 2 0 0 2 2 2 0 FAM76 protein Trm112p PF03966.16 ELR22189.1 - 4.2e-15 56.1 0.0 8.9e-15 55.0 0.0 1.5 1 1 0 1 1 1 1 Trm112p-like protein HAD_2 PF13419.6 ELR22190.1 - 3.3e-19 69.7 0.0 1.2e-18 67.8 0.0 1.7 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 ELR22190.1 - 6.9e-10 39.6 2.6 1.7e-07 31.8 2.6 2.3 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 ELR22190.1 - 0.00012 22.1 0.1 0.00031 20.8 0.1 1.7 2 0 0 2 2 2 1 HAD-hyrolase-like DAGAT PF03982.13 ELR22191.1 - 3.5e-61 206.7 0.1 4.8e-61 206.3 0.1 1.1 1 0 0 1 1 1 1 Diacylglycerol acyltransferase CsbD PF05532.12 ELR22192.1 - 0.00023 21.0 2.9 0.00023 21.0 2.9 2.9 3 0 0 3 3 3 1 CsbD-like Herpes_gE PF02480.16 ELR22193.1 - 0.054 12.2 0.0 0.084 11.6 0.0 1.2 1 0 0 1 1 1 0 Alphaherpesvirus glycoprotein E DAP10 PF07213.11 ELR22193.1 - 0.073 13.0 6.0 2.5 8.1 0.4 2.7 2 0 0 2 2 2 0 DAP10 membrane protein PDCD2_C PF04194.13 ELR22194.1 - 0.086 12.9 0.1 1 9.4 0.0 2.2 2 0 0 2 2 2 0 Programmed cell death protein 2, C-terminal putative domain G-alpha PF00503.20 ELR22196.1 - 6e-106 354.6 6.1 7e-106 354.4 6.1 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 ELR22196.1 - 7.6e-14 51.5 4.5 1.2e-10 41.1 0.7 2.6 2 1 0 2 2 2 2 ADP-ribosylation factor family Gtr1_RagA PF04670.12 ELR22196.1 - 7.8e-06 25.4 2.4 0.00051 19.5 0.4 2.3 2 0 0 2 2 2 2 Gtr1/RagA G protein conserved region Sigma54_activat PF00158.26 ELR22196.1 - 0.0035 17.1 0.2 0.0056 16.4 0.2 1.3 1 0 0 1 1 1 1 Sigma-54 interaction domain MMR_HSR1 PF01926.23 ELR22196.1 - 0.011 15.9 0.2 0.13 12.4 0.1 2.4 2 0 0 2 2 2 0 50S ribosome-binding GTPase Roc PF08477.13 ELR22196.1 - 0.032 14.4 1.6 6.8 6.9 0.1 2.8 3 0 0 3 3 3 0 Ras of Complex, Roc, domain of DAPkinase GTP_EFTU PF00009.27 ELR22196.1 - 0.24 10.9 1.6 0.53 9.8 0.2 2.3 2 2 1 3 3 3 0 Elongation factor Tu GTP binding domain DUF2457 PF10446.9 ELR22198.1 - 0.034 13.3 15.4 0.048 12.8 15.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) SpoIIIAH PF12685.7 ELR22198.1 - 0.97 9.2 10.4 1.3 8.8 10.4 1.2 1 0 0 1 1 1 0 SpoIIIAH-like protein DUF5127 PF17168.4 ELR22200.1 - 1.7e-61 207.9 0.0 2.4e-61 207.4 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF5127) DUF4965 PF16335.5 ELR22200.1 - 2.5e-57 193.3 0.0 6.2e-57 192.0 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4965) DUF1793 PF08760.11 ELR22200.1 - 1.4e-44 152.5 2.0 1.4e-44 152.5 2.0 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF1793) DUF4964 PF16334.5 ELR22200.1 - 1.6e-17 62.8 0.1 3.5e-17 61.7 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4964) Glycolipid_bind PF06475.11 ELR22200.1 - 0.071 12.6 0.0 0.31 10.5 0.0 1.9 2 0 0 2 2 2 0 Putative glycolipid-binding AMP-binding PF00501.28 ELR22201.1 - 2.4e-76 257.0 0.0 2e-70 237.5 0.0 2.3 1 1 1 2 2 2 2 AMP-binding enzyme AMP-binding_C PF13193.6 ELR22201.1 - 0.00052 20.9 2.3 0.0011 19.8 1.6 2.0 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain Colipase PF01114.18 ELR22202.1 - 0.0095 15.6 0.8 0.0095 15.6 0.8 2.0 1 1 1 2 2 2 1 Colipase, N-terminal domain Podoplanin PF05808.11 ELR22202.1 - 0.081 13.0 0.0 0.097 12.8 0.0 1.1 1 0 0 1 1 1 0 Podoplanin FTR1 PF03239.14 ELR22202.1 - 0.11 11.6 0.0 0.12 11.5 0.0 1.0 1 0 0 1 1 1 0 Iron permease FTR1 family CD34_antigen PF06365.12 ELR22202.1 - 0.12 11.9 0.0 0.13 11.8 0.0 1.1 1 0 0 1 1 1 0 CD34/Podocalyxin family DUF2207 PF09972.9 ELR22202.1 - 0.21 10.3 0.0 0.22 10.3 0.0 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Helicase_C PF00271.31 ELR22203.1 - 6.6e-13 49.0 0.2 5.3e-12 46.1 0.0 2.4 2 1 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 ELR22203.1 - 3.6e-07 30.1 0.3 9.4e-06 25.5 0.1 2.9 2 1 1 3 3 3 1 DEAD/DEAH box helicase HHH_5 PF14520.6 ELR22203.1 - 0.0047 17.5 0.1 0.016 15.8 0.0 1.9 2 0 0 2 2 2 1 Helix-hairpin-helix domain Sigma70_r4 PF04545.16 ELR22203.1 - 0.086 12.4 0.1 3.9 7.1 0.0 2.6 2 0 0 2 2 2 0 Sigma-70, region 4 HSP20 PF00011.21 ELR22204.1 - 7.2e-06 26.1 0.0 1.6e-05 25.0 0.0 1.6 1 0 0 1 1 1 1 Hsp20/alpha crystallin family SbcD_C PF12320.8 ELR22204.1 - 0.01 16.1 2.4 2.7 8.4 0.1 2.4 2 0 0 2 2 2 0 Type 5 capsule protein repressor C-terminal domain Pkinase_Tyr PF07714.17 ELR22205.1 - 1.3e-65 221.3 0.0 3e-65 220.1 0.0 1.6 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ELR22205.1 - 3.8e-41 141.2 0.0 9.5e-41 139.9 0.0 1.6 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.23 ELR22205.1 - 0.0057 16.6 0.9 0.012 15.6 0.0 2.0 2 0 0 2 2 2 1 Phosphotransferase enzyme family Sel_put PF04328.13 ELR22205.1 - 0.018 15.1 0.2 0.093 12.8 0.0 2.3 3 0 0 3 3 3 0 Selenoprotein, putative Exonuc_V_gamma PF04257.14 ELR22205.1 - 0.028 12.6 1.1 0.052 11.8 1.1 1.3 1 0 0 1 1 1 0 Exodeoxyribonuclease V, gamma subunit Cofilin_ADF PF00241.20 ELR22206.1 - 5e-21 74.7 0.0 5.8e-21 74.5 0.0 1.0 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein CDCA PF18484.1 ELR22206.1 - 0.012 15.5 0.1 0.044 13.6 0.0 1.7 1 1 1 2 2 2 0 Cadmium carbonic anhydrase repeat Pkinase PF00069.25 ELR22207.1 - 2.4e-44 151.7 0.0 3e-44 151.4 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR22207.1 - 1.5e-26 93.3 0.0 1.8e-26 93.0 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ELR22207.1 - 9.6e-07 28.4 0.0 6.1e-06 25.8 0.0 1.9 1 1 1 2 2 2 1 Kinase-like APH PF01636.23 ELR22207.1 - 1.6e-05 25.0 0.2 0.026 14.4 0.2 2.3 1 1 1 2 2 2 2 Phosphotransferase enzyme family SPACA9 PF15120.6 ELR22207.1 - 0.067 13.0 0.0 0.11 12.3 0.0 1.4 1 0 0 1 1 1 0 Sperm acrosome-associated protein 9 Pro_isomerase PF00160.21 ELR22208.1 - 2.4e-44 151.4 0.0 2.6e-44 151.3 0.0 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD DUF987 PF06174.11 ELR22208.1 - 0.074 13.0 0.0 0.12 12.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF987) F-box-like PF12937.7 ELR22210.1 - 6.3e-10 38.8 0.5 1.5e-09 37.6 0.5 1.6 1 0 0 1 1 1 1 F-box-like Beta_helix PF13229.6 ELR22210.1 - 1.6e-09 37.8 3.1 3.1e-09 36.9 3.1 1.4 1 0 0 1 1 1 1 Right handed beta helix region F-box PF00646.33 ELR22210.1 - 1.5e-06 27.9 0.1 3.8e-06 26.6 0.1 1.8 1 0 0 1 1 1 1 F-box domain Pectate_lyase_3 PF12708.7 ELR22210.1 - 1.6e-05 24.9 4.0 0.8 9.5 0.2 3.0 1 1 1 3 3 3 3 Pectate lyase superfamily protein NosD PF05048.13 ELR22210.1 - 0.062 12.5 0.3 0.11 11.7 0.3 1.3 1 0 0 1 1 1 0 Periplasmic copper-binding protein (NosD) Phage_HK97_TLTM PF06120.11 ELR22211.1 - 0.33 10.1 0.8 0.45 9.7 0.8 1.1 1 0 0 1 1 1 0 Tail length tape measure protein DUF4813 PF16072.5 ELR22211.1 - 0.82 9.3 9.7 0.12 12.0 4.8 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4813) Mito_carr PF00153.27 ELR22212.1 - 1e-70 233.7 0.1 8.7e-24 83.3 0.0 3.4 3 0 0 3 3 3 3 Mitochondrial carrier protein EF-hand_7 PF13499.6 ELR22212.1 - 1.3e-09 38.4 0.1 0.0021 18.5 0.0 2.6 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 ELR22212.1 - 5.4e-05 22.8 0.1 1.7 8.8 0.0 3.7 3 0 0 3 3 3 2 EF-hand domain EF-hand_4 PF12763.7 ELR22212.1 - 0.0001 22.2 0.0 0.0012 18.8 0.0 2.1 1 1 1 2 2 2 1 Cytoskeletal-regulatory complex EF hand EF-hand_1 PF00036.32 ELR22212.1 - 0.029 13.9 1.0 16 5.4 0.0 3.7 3 1 1 4 4 4 0 EF hand EF-hand_10 PF14788.6 ELR22212.1 - 0.045 13.6 0.0 0.11 12.4 0.0 1.6 1 0 0 1 1 1 0 EF hand DUF1771 PF08590.10 ELR22213.1 - 7.6e-13 48.6 0.8 2.1e-12 47.2 0.1 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF1771) Smr PF01713.21 ELR22213.1 - 2.4e-08 34.2 0.2 4e-08 33.5 0.2 1.4 1 0 0 1 1 1 1 Smr domain CUE PF02845.16 ELR22214.1 - 1.4e-15 56.7 5.8 1e-05 25.1 0.1 3.9 4 0 0 4 4 4 3 CUE domain DUF724 PF05266.14 ELR22214.1 - 0.0014 18.5 2.3 0.0014 18.5 2.3 2.7 2 0 0 2 2 2 1 Protein of unknown function (DUF724) DMA PF03474.14 ELR22214.1 - 0.089 12.4 0.4 3.8 7.2 0.0 2.8 3 0 0 3 3 3 0 DMRTA motif ACT_7 PF13840.6 ELR22215.1 - 2e-25 88.4 0.0 5.6e-13 48.5 0.0 2.7 2 0 0 2 2 2 2 ACT domain Castor1_N PF18700.1 ELR22215.1 - 0.0013 18.5 0.3 0.51 10.2 0.1 2.8 3 0 0 3 3 3 2 Cytosolic arginine sensor for mTORC1 subunit 1 N-terminal domain MFS_2 PF13347.6 ELR22216.1 - 1.5e-97 326.9 21.5 1.9e-97 326.5 21.5 1.1 1 0 0 1 1 1 1 MFS/sugar transport protein MFS_1 PF07690.16 ELR22216.1 - 1.6e-23 83.2 42.4 6.2e-18 64.8 23.3 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily PUCC PF03209.15 ELR22216.1 - 5.9e-06 25.5 5.6 8.7e-06 25.0 5.6 1.2 1 0 0 1 1 1 1 PUCC protein MFS_1_like PF12832.7 ELR22216.1 - 6.6e-05 21.9 20.5 0.00014 20.8 17.5 2.5 1 1 2 3 3 3 1 MFS_1 like family CCB1 PF12046.8 ELR22216.1 - 0.7 9.2 0.0 0.7 9.2 0.0 2.7 3 1 1 4 4 4 0 Cofactor assembly of complex C subunit B Na_Ca_ex PF01699.24 ELR22217.1 - 1.3e-14 54.4 50.6 1.8e-12 47.5 21.2 3.3 3 1 0 3 3 2 2 Sodium/calcium exchanger protein YccF PF03733.13 ELR22217.1 - 1.1e-12 48.4 6.6 1.1e-12 48.4 6.6 4.9 6 1 1 7 7 4 2 Inner membrane component domain SR-25 PF10500.9 ELR22217.1 - 0.027 14.1 20.9 0.047 13.3 20.9 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein TLP-20 PF06088.11 ELR22217.1 - 0.43 10.4 10.5 0.62 9.9 8.2 2.0 2 0 0 2 2 2 0 Nucleopolyhedrovirus telokin-like protein-20 (TLP20) FAM60A PF15396.6 ELR22217.1 - 0.54 10.2 10.4 0.88 9.5 10.4 1.2 1 0 0 1 1 1 0 Protein Family FAM60A Rtf2 PF04641.12 ELR22217.1 - 0.57 9.5 15.7 0.88 8.9 15.7 1.2 1 0 0 1 1 1 0 Rtf2 RING-finger DDHD PF02862.17 ELR22217.1 - 0.72 10.0 4.2 1.2 9.3 4.2 1.2 1 0 0 1 1 1 0 DDHD domain DUF1754 PF08555.10 ELR22217.1 - 0.74 10.6 21.1 1.6 9.6 21.1 1.5 1 0 0 1 1 1 0 Eukaryotic family of unknown function (DUF1754) CDC45 PF02724.14 ELR22217.1 - 0.74 8.0 13.6 1 7.5 13.6 1.1 1 0 0 1 1 1 0 CDC45-like protein RR_TM4-6 PF06459.12 ELR22217.1 - 2.7 7.8 15.4 4.8 6.9 15.4 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF3807 PF12720.7 ELR22217.1 - 3.4 7.9 16.6 5.2 7.3 16.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) Apt1 PF10351.9 ELR22217.1 - 3.6 6.3 10.9 5 5.9 10.9 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain DUF4746 PF15928.5 ELR22217.1 - 3.7 6.9 12.2 6.4 6.1 12.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) DNA_pol_phi PF04931.13 ELR22217.1 - 5 5.1 16.2 8.4 4.4 16.2 1.2 1 0 0 1 1 1 0 DNA polymerase phi Hid1 PF12722.7 ELR22217.1 - 5.4 5.0 11.1 8.7 4.3 11.1 1.2 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Menin PF05053.13 ELR22217.1 - 5.5 5.2 10.2 8.2 4.6 10.2 1.2 1 0 0 1 1 1 0 Menin FancD2 PF14631.6 ELR22217.1 - 7.6 3.8 11.8 11 3.3 11.8 1.0 1 0 0 1 1 1 0 Fanconi anaemia protein FancD2 nuclease DUF913 PF06025.12 ELR22217.1 - 7.7 5.4 8.8 14 4.5 8.8 1.4 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) RNA_pol_Rpc4 PF05132.14 ELR22217.1 - 9.2 6.7 11.5 16 5.9 11.5 1.4 1 0 0 1 1 1 0 RNA polymerase III RPC4 CCDC106 PF15794.5 ELR22217.1 - 9.5 5.9 18.7 15 5.2 18.7 1.2 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 SET PF00856.28 ELR22218.1 - 1.4e-14 54.9 0.1 2.7e-14 53.9 0.1 1.5 1 1 0 1 1 1 1 SET domain SAF PF08666.12 ELR22218.1 - 0.12 13.0 0.0 15 6.3 0.0 2.5 2 0 0 2 2 2 0 SAF domain TPR_12 PF13424.6 ELR22219.1 - 0.00095 19.4 41.2 0.11 12.8 2.2 7.6 7 1 0 7 7 7 3 Tetratricopeptide repeat TPR_8 PF13181.6 ELR22219.1 - 0.019 15.2 13.3 0.73 10.2 0.3 5.7 6 0 0 6 6 6 0 Tetratricopeptide repeat SNAP PF14938.6 ELR22219.1 - 0.034 13.6 4.1 0.65 9.4 0.5 3.4 3 1 1 4 4 4 0 Soluble NSF attachment protein, SNAP HTH_Bact PF18768.1 ELR22219.1 - 0.036 13.6 0.8 0.079 12.6 0.3 1.8 2 0 0 2 2 2 0 Helix-turn-helix bacterial domain TPR_1 PF00515.28 ELR22219.1 - 0.085 12.7 4.4 1 9.3 0.2 4.3 3 0 0 3 3 3 0 Tetratricopeptide repeat FAM199X PF15814.5 ELR22219.1 - 1.9 7.4 6.9 4.8 6.1 6.9 1.6 1 0 0 1 1 1 0 Protein family FAM199X TPR_19 PF14559.6 ELR22219.1 - 4 8.0 19.6 0.11 13.0 1.5 5.3 4 2 2 6 6 6 0 Tetratricopeptide repeat NAD_binding_8 PF13450.6 ELR22221.1 - 0.1 12.8 0.0 0.24 11.7 0.0 1.7 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain FA_hydroxylase PF04116.13 ELR22222.1 - 1.6e-24 86.8 23.2 2e-24 86.4 21.9 1.7 2 0 0 2 2 2 1 Fatty acid hydroxylase superfamily GFO_IDH_MocA PF01408.22 ELR22223.1 - 3e-22 79.7 0.3 5.7e-22 78.8 0.3 1.5 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.17 ELR22223.1 - 6.9e-06 26.1 0.0 2.7e-05 24.2 0.0 2.0 2 0 0 2 2 2 1 Oxidoreductase family, C-terminal alpha/beta domain Shikimate_DH PF01488.20 ELR22223.1 - 0.11 12.6 0.0 0.21 11.6 0.0 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Rap_GAP PF02145.15 ELR22225.1 - 1e-56 191.5 0.0 1.4e-56 191.0 0.0 1.2 1 0 0 1 1 1 1 Rap/ran-GAP LIM PF00412.22 ELR22225.1 - 5.3e-29 100.2 26.6 2.8e-11 43.4 1.4 4.2 4 0 0 4 4 4 3 LIM domain Prok-RING_4 PF14447.6 ELR22225.1 - 0.097 12.6 4.6 3.4 7.6 0.5 3.3 2 0 0 2 2 2 0 Prokaryotic RING finger family 4 Ribosomal_L40e PF01020.17 ELR22225.1 - 1.4 8.9 0.0 1.4 8.9 0.0 3.5 3 1 1 4 4 4 0 Ribosomal L40e family adh_short PF00106.25 ELR22226.1 - 3.5e-18 65.8 0.0 1.2e-09 37.9 0.0 2.3 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 ELR22226.1 - 2.2e-15 56.9 0.0 4.1e-08 33.1 0.0 2.5 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase FliT PF05400.13 ELR22226.1 - 0.12 13.2 0.5 0.31 11.9 0.5 1.7 1 0 0 1 1 1 0 Flagellar protein FliT FAM176 PF14851.6 ELR22226.1 - 0.65 9.6 2.2 14 5.4 0.1 2.4 2 0 0 2 2 2 0 FAM176 family RRM_1 PF00076.22 ELR22227.1 - 5.2e-39 131.9 0.0 3.2e-13 49.3 0.0 3.3 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 ELR22227.1 - 1.6e-05 24.8 0.1 0.0019 18.2 0.0 3.1 3 0 0 3 3 3 1 Nup53/35/40-type RNA recognition motif RRM_5 PF13893.6 ELR22227.1 - 4.2e-05 23.1 0.0 0.27 10.9 0.0 3.5 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RL PF17797.1 ELR22227.1 - 9.4e-05 22.3 0.1 0.13 12.2 0.0 2.9 3 0 0 3 3 3 2 RL domain RRM_7 PF16367.5 ELR22227.1 - 0.00092 19.3 0.0 0.44 10.7 0.0 3.4 3 0 0 3 3 3 1 RNA recognition motif Glyco_hydro_64 PF16483.5 ELR22227.1 - 0.0036 16.6 0.1 0.21 10.8 0.0 2.8 3 0 0 3 3 3 1 Beta-1,3-glucanase Nup35_RRM PF05172.13 ELR22227.1 - 0.035 14.1 0.0 1.3 9.0 0.0 3.0 3 0 0 3 3 3 0 Nup53/35/40-type RNA recognition motif SMAP PF15477.6 ELR22227.1 - 0.038 14.9 1.8 0.038 14.9 1.8 2.4 2 1 0 2 2 1 0 Small acidic protein family DUF1152 PF06626.12 ELR22227.1 - 0.076 12.2 1.8 1.3 8.2 0.0 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF1152) TFIIA PF03153.13 ELR22227.1 - 0.25 11.3 16.1 0.37 10.7 16.1 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit PHM7_cyt PF14703.6 ELR22227.1 - 1.6 8.9 14.1 26 5.0 0.0 5.7 3 3 3 6 6 5 0 Cytosolic domain of 10TM putative phosphate transporter Nucleo_P87 PF07267.11 ELR22227.1 - 8.8 5.0 12.1 12 4.6 12.1 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 CENP-X PF09415.10 ELR22228.1 - 4.4e-15 55.8 0.0 4.7e-15 55.7 0.0 1.0 1 0 0 1 1 1 1 CENP-S associating Centromere protein X CBFD_NFYB_HMF PF00808.23 ELR22228.1 - 0.066 13.5 0.0 0.071 13.4 0.0 1.0 1 0 0 1 1 1 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone bVLRF1 PF18826.1 ELR22229.1 - 2.4e-42 144.3 0.0 4.5e-42 143.4 0.0 1.5 1 0 0 1 1 1 1 bacteroidetes VLRF1 release factor VATC PF18716.1 ELR22229.1 - 8e-12 44.8 2.8 8e-12 44.8 2.8 2.0 2 0 0 2 2 2 1 Vms1-associating treble clef domain Ank_4 PF13637.6 ELR22229.1 - 3e-10 40.4 0.2 6.1e-06 26.7 0.1 2.4 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 ELR22229.1 - 5.7e-10 39.6 0.0 9.8e-10 38.9 0.0 1.4 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 ELR22229.1 - 2e-09 37.5 1.3 5.2e-05 23.5 0.0 3.4 1 1 2 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 ELR22229.1 - 5.1e-08 32.6 0.9 0.0083 16.6 0.1 3.0 3 0 0 3 3 3 2 Ankyrin repeat Ank PF00023.30 ELR22229.1 - 2.5e-06 27.7 1.0 0.014 15.8 0.1 2.6 2 0 0 2 2 2 2 Ankyrin repeat zf-C2H2_jaz PF12171.8 ELR22229.1 - 0.048 13.9 0.6 0.25 11.7 0.1 2.2 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding UIM PF02809.20 ELR22229.1 - 0.55 10.3 7.6 0.079 12.9 2.1 2.7 2 0 0 2 2 2 0 Ubiquitin interaction motif zf-MYND PF01753.18 ELR22229.1 - 2.2 8.5 5.0 0.85 9.8 1.2 2.1 2 0 0 2 2 2 0 MYND finger eIF3_subunit PF08597.10 ELR22229.1 - 3 7.7 41.6 0.056 13.3 26.1 3.0 3 0 0 3 3 3 0 Translation initiation factor eIF3 subunit DUF2052 PF09747.9 ELR22229.1 - 8.6 6.4 31.9 19 5.3 20.7 3.4 3 0 0 3 3 3 0 Coiled-coil domain containing protein (DUF2052) Cupin_2 PF07883.11 ELR22230.1 - 7.4e-12 44.8 0.0 8.4e-12 44.6 0.0 1.1 1 0 0 1 1 1 1 Cupin domain Cupin_1 PF00190.22 ELR22230.1 - 0.0012 18.5 0.0 0.0016 18.1 0.0 1.1 1 0 0 1 1 1 1 Cupin Cupin_7 PF12973.7 ELR22230.1 - 0.0031 17.4 0.0 0.0034 17.3 0.0 1.2 1 0 0 1 1 1 1 ChrR Cupin-like domain MannoseP_isomer PF01050.18 ELR22230.1 - 0.0034 17.3 0.0 0.0038 17.1 0.0 1.0 1 0 0 1 1 1 1 Mannose-6-phosphate isomerase AraC_binding PF02311.19 ELR22230.1 - 0.022 14.7 0.0 0.034 14.1 0.0 1.4 1 1 0 1 1 1 0 AraC-like ligand binding domain YPEB PF14620.6 ELR22231.1 - 0.022 14.1 0.0 0.03 13.7 0.0 1.1 1 0 0 1 1 1 0 YpeB sporulation DUF962 PF06127.11 ELR22233.1 - 1.7e-25 88.9 0.1 3.7e-25 87.8 0.1 1.6 1 1 0 1 1 1 1 Protein of unknown function (DUF962) Insulin_TMD PF17870.1 ELR22233.1 - 3.8 7.7 6.4 5 7.3 0.2 2.8 3 0 0 3 3 3 0 Insulin receptor trans-membrane segment DUF3267 PF11667.8 ELR22233.1 - 5.8 7.2 10.9 1.1 9.6 0.7 3.1 2 1 1 3 3 3 0 Putative zincin peptidase Beta-lactamase PF00144.24 ELR22234.1 - 1.4e-38 133.0 0.0 2.6e-38 132.1 0.0 1.3 1 0 0 1 1 1 1 Beta-lactamase Peptidase_S11 PF00768.20 ELR22234.1 - 0.027 13.9 0.0 0.055 12.9 0.0 1.4 1 0 0 1 1 1 0 D-alanyl-D-alanine carboxypeptidase SAM_1 PF00536.30 ELR22235.1 - 3.5e-12 46.6 0.1 5.8e-12 45.9 0.1 1.3 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 ELR22235.1 - 2.3e-09 37.2 0.0 4.1e-09 36.4 0.0 1.3 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Tissue_fac PF01108.17 ELR22238.1 - 0.13 12.2 0.3 0.97 9.3 0.0 2.5 3 0 0 3 3 3 0 Tissue factor NEL PF14496.6 ELR22241.1 - 0.028 13.8 0.0 0.033 13.6 0.0 1.1 1 0 0 1 1 1 0 C-terminal novel E3 ligase, LRR-interacting GnHR_trans PF12369.8 ELR22242.1 - 0.013 16.3 0.2 17 6.3 0.0 3.0 3 0 0 3 3 3 0 Gonadotropin hormone receptor transmembrane region GGA_N-GAT PF18308.1 ELR22242.1 - 0.13 11.9 0.1 26 4.6 0.0 2.4 2 0 0 2 2 2 0 GGA N-GAT domain AHD PF17793.1 ELR22242.1 - 0.39 10.5 2.5 20 5.1 0.2 2.3 2 0 0 2 2 2 0 ANC1 homology domain (AHD) Pkinase PF00069.25 ELR22243.1 - 1.5e-28 99.9 0.0 2.2e-28 99.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR22243.1 - 4.8e-05 22.8 0.0 7.2e-05 22.2 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 ELR22243.1 - 0.00059 19.8 0.6 0.00059 19.8 0.6 2.6 2 1 0 2 2 2 1 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 ELR22243.1 - 0.002 17.0 0.1 0.0095 14.7 0.0 1.9 2 0 0 2 2 2 1 Fungal protein kinase Kinase-like PF14531.6 ELR22243.1 - 0.0034 16.8 0.0 0.0056 16.0 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 ELR22243.1 - 0.0075 15.6 0.1 0.017 14.5 0.1 1.6 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 ELR22243.1 - 0.03 13.3 0.0 0.042 12.8 0.0 1.2 1 0 0 1 1 1 0 Haspin like kinase domain Pox_ser-thr_kin PF05445.11 ELR22243.1 - 0.06 12.3 0.1 0.087 11.8 0.1 1.1 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase SDA1 PF05285.12 ELR22243.1 - 0.11 11.9 16.6 0.13 11.6 16.6 1.1 1 0 0 1 1 1 0 SDA1 CDC45 PF02724.14 ELR22243.1 - 0.41 8.9 10.8 0.55 8.5 10.8 1.1 1 0 0 1 1 1 0 CDC45-like protein Nop14 PF04147.12 ELR22243.1 - 1 7.5 17.5 1.3 7.1 17.5 1.1 1 0 0 1 1 1 0 Nop14-like family Resolvase PF00239.21 ELR22244.1 - 2.5e-14 53.6 0.3 4.8e-14 52.7 0.3 1.5 1 0 0 1 1 1 1 Resolvase, N terminal domain OrfB_Zn_ribbon PF07282.11 ELR22244.1 - 8.7e-08 32.0 1.2 2.2e-07 30.7 1.2 1.7 1 0 0 1 1 1 1 Putative transposase DNA-binding domain HTH_OrfB_IS605 PF12323.8 ELR22244.1 - 0.00021 20.7 0.1 0.00075 18.9 0.1 1.9 1 0 0 1 1 1 1 Helix-turn-helix domain MerR_1 PF13411.6 ELR22244.1 - 0.0023 18.0 0.0 0.0048 16.9 0.0 1.6 1 0 0 1 1 1 1 MerR HTH family regulatory protein OrfB_IS605 PF01385.19 ELR22244.1 - 0.0073 16.5 0.0 0.0073 16.5 0.0 3.2 3 1 0 3 3 3 1 Probable transposase HTH_17 PF12728.7 ELR22244.1 - 0.065 13.4 1.9 0.29 11.3 0.0 2.8 2 0 0 2 2 2 0 Helix-turn-helix domain Pkinase_Tyr PF07714.17 ELR22245.1 - 2.5e-126 420.3 5.5 1.1e-52 179.0 5.3 4.2 4 0 0 4 4 4 4 Protein tyrosine kinase Pkinase PF00069.25 ELR22245.1 - 5.8e-111 370.1 0.0 7.5e-54 182.9 0.1 3.7 3 1 0 3 3 3 3 Protein kinase domain Kinase-like PF14531.6 ELR22245.1 - 1.5e-06 27.8 0.0 0.14 11.5 0.0 3.1 3 0 0 3 3 3 2 Kinase-like Zip PF02535.22 ELR22245.1 - 0.0002 20.7 20.6 0.00056 19.2 20.6 1.7 1 0 0 1 1 1 1 ZIP Zinc transporter TFIIA PF03153.13 ELR22245.1 - 0.00048 20.3 19.4 0.0011 19.0 19.4 1.7 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit Otopetrin PF03189.13 ELR22245.1 - 0.011 14.6 8.0 0.051 12.4 6.0 2.2 2 0 0 2 2 2 0 Otopetrin Presenilin PF01080.17 ELR22245.1 - 0.095 11.5 15.3 0.38 9.5 15.3 2.0 1 0 0 1 1 1 0 Presenilin Neur_chan_memb PF02932.16 ELR22245.1 - 0.16 12.0 10.8 0.23 11.5 8.3 2.4 3 0 0 3 3 3 0 Neurotransmitter-gated ion-channel transmembrane region TMEM154 PF15102.6 ELR22245.1 - 0.17 11.8 0.0 0.17 11.8 0.0 2.3 3 0 0 3 3 3 0 TMEM154 protein family SPX PF03105.19 ELR22245.1 - 0.18 11.7 15.1 0.11 12.4 10.8 2.2 2 0 0 2 2 2 0 SPX domain Peptidase_S64 PF08192.11 ELR22245.1 - 0.23 9.9 16.0 0.021 13.3 8.2 2.1 2 0 0 2 2 2 0 Peptidase family S64 CLN3 PF02487.17 ELR22245.1 - 0.33 9.9 6.9 0.58 9.1 6.9 1.3 1 0 0 1 1 1 0 CLN3 protein MDM10 PF12519.8 ELR22245.1 - 0.52 9.1 9.1 0.96 8.2 9.1 1.3 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 V_ATPase_I PF01496.19 ELR22245.1 - 0.7 7.7 24.3 0.22 9.4 18.7 2.2 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family DUF2347 PF09804.9 ELR22245.1 - 1.1 8.8 9.0 2.2 7.8 9.0 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2347) eIF-3_zeta PF05091.12 ELR22245.1 - 1.9 7.4 13.1 1.1 8.1 11.2 1.5 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) FAM76 PF16046.5 ELR22245.1 - 2.3 7.5 22.0 6.1 6.1 22.0 1.7 1 0 0 1 1 1 0 FAM76 protein Hid1 PF12722.7 ELR22245.1 - 5.4 5.0 10.7 8.7 4.3 10.7 1.2 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein LMBR1 PF04791.16 ELR22245.1 - 7.3 5.4 6.0 31 3.3 0.0 2.2 2 0 0 2 2 2 0 LMBR1-like membrane protein Pkinase_Tyr PF07714.17 ELR22246.1 - 4.3e-48 163.9 0.1 3.7e-44 151.0 0.0 2.2 1 1 1 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 ELR22246.1 - 2e-43 148.7 0.0 4.3e-42 144.3 0.0 2.1 1 1 1 2 2 2 1 Protein kinase domain PBP_like_2 PF12849.7 ELR22246.1 - 4e-27 95.6 10.9 9.2e-15 55.1 5.5 2.3 2 0 0 2 2 2 2 PBP superfamily domain Kinase-like PF14531.6 ELR22246.1 - 0.0091 15.3 0.0 0.11 11.9 0.0 2.0 2 0 0 2 2 2 1 Kinase-like EGF_2 PF07974.13 ELR22246.1 - 0.017 15.5 11.7 0.03 14.7 11.7 1.4 1 0 0 1 1 1 0 EGF-like domain Guanylate_cyc PF00211.20 ELR22246.1 - 0.042 13.5 0.0 0.081 12.5 0.0 1.4 1 0 0 1 1 1 0 Adenylate and Guanylate cyclase catalytic domain Stevor PF17410.2 ELR22246.1 - 0.097 12.2 0.0 0.28 10.7 0.0 1.7 1 0 0 1 1 1 0 Subtelomeric Variable Open Reading frame FTA2 PF13095.6 ELR22246.1 - 0.12 12.0 0.0 0.27 10.8 0.0 1.5 1 1 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 MID_MedPIWI PF18296.1 ELR22246.1 - 0.17 11.7 0.2 1.1 9.0 0.0 2.1 2 0 0 2 2 2 0 MID domain of medPIWI RIO1 PF01163.22 ELR22246.1 - 0.24 11.0 0.4 1.6 8.3 0.1 2.0 1 1 1 2 2 2 0 RIO1 family F-box-like PF12937.7 ELR22247.1 - 9.1e-14 51.1 1.2 3.6e-13 49.2 0.4 2.5 3 0 0 3 3 3 1 F-box-like Ank_2 PF12796.7 ELR22247.1 - 3.9e-13 49.8 2.1 3.8e-06 27.4 0.0 3.3 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_3 PF13606.6 ELR22247.1 - 6.5e-10 38.4 1.5 0.0036 17.7 0.0 4.5 4 0 0 4 4 4 2 Ankyrin repeat Ank_5 PF13857.6 ELR22247.1 - 9e-10 38.6 2.3 0.00076 19.7 0.0 4.5 4 0 0 4 4 4 2 Ankyrin repeats (many copies) F-box PF00646.33 ELR22247.1 - 6.8e-09 35.4 0.2 2.2e-08 33.8 0.0 2.0 2 0 0 2 2 2 1 F-box domain Ank PF00023.30 ELR22247.1 - 2e-06 28.0 2.2 0.0035 17.7 0.0 4.3 4 0 0 4 4 4 1 Ankyrin repeat Ank_4 PF13637.6 ELR22247.1 - 2.2e-06 28.1 0.1 0.00044 20.8 0.0 3.2 3 1 1 4 4 4 1 Ankyrin repeats (many copies) S_4TM PF18159.1 ELR22248.1 - 0.091 12.0 1.5 3 7.0 0.1 2.8 3 0 0 3 3 3 0 SMODS-associating 4TM effector domain TFIIA PF03153.13 ELR22249.1 - 0.0081 16.2 8.7 0.011 15.8 8.7 1.2 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit Pkinase PF00069.25 ELR22250.1 - 6.2e-59 199.5 0.0 6.1e-57 193.0 0.0 2.2 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR22250.1 - 2.7e-34 118.6 0.0 3.7e-34 118.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase PH_3 PF14593.6 ELR22250.1 - 1.8e-25 89.0 0.7 1.8e-25 89.0 0.7 2.1 2 0 0 2 2 2 1 PH domain APH PF01636.23 ELR22250.1 - 9.6e-06 25.7 0.0 1.5e-05 25.0 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kinase-like PF14531.6 ELR22250.1 - 4e-05 23.1 0.0 7.3e-05 22.2 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 ELR22250.1 - 0.00011 21.6 0.1 0.00021 20.7 0.1 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 ELR22250.1 - 0.00012 21.0 0.0 0.0002 20.3 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase RIO1 PF01163.22 ELR22250.1 - 0.0077 15.9 0.0 0.02 14.5 0.0 1.7 1 0 0 1 1 1 1 RIO1 family Haspin_kinase PF12330.8 ELR22250.1 - 0.042 12.8 0.1 0.13 11.2 0.1 1.7 2 0 0 2 2 2 0 Haspin like kinase domain Myosin_TH1 PF06017.13 ELR22250.1 - 0.057 13.1 0.1 0.11 12.2 0.1 1.5 1 0 0 1 1 1 0 Unconventional myosin tail, actin- and lipid-binding Ank_3 PF13606.6 ELR22251.1 - 8.7e-20 68.7 1.8 0.037 14.6 0.0 9.5 10 0 0 10 10 10 4 Ankyrin repeat Ank_2 PF12796.7 ELR22251.1 - 1.1e-19 70.7 0.0 2.2e-05 24.9 0.0 5.8 3 3 2 5 5 5 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ELR22251.1 - 2.7e-14 53.3 0.0 0.00068 20.2 0.0 6.7 6 1 1 7 7 7 3 Ankyrin repeats (many copies) Ank PF00023.30 ELR22251.1 - 4.4e-09 36.4 4.5 1.1 9.9 0.0 7.0 8 0 0 8 8 8 3 Ankyrin repeat Ank_5 PF13857.6 ELR22251.1 - 1.3e-06 28.6 6.8 2.2 8.7 0.0 7.4 7 1 2 9 9 9 3 Ankyrin repeats (many copies) Toprim_Crpt PF13342.6 ELR22253.1 - 0.09 12.8 0.6 20 5.3 0.1 2.4 2 0 0 2 2 2 0 C-terminal repeat of topoisomerase DUF3034 PF11231.8 ELR22253.1 - 0.14 11.7 0.0 19 4.7 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3034) Surfac_D-trimer PF09006.11 ELR22253.1 - 0.48 10.4 2.8 22 5.0 0.2 2.4 2 0 0 2 2 2 0 Lung surfactant protein D coiled-coil trimerisation WRNPLPNID PF15017.6 ELR22253.1 - 4.8 8.1 13.0 13 6.7 2.4 2.6 2 0 0 2 2 2 0 Putative WW-binding domain and destruction box Metallophos PF00149.28 ELR22254.1 - 9.2e-15 55.7 0.0 1.5e-14 55.0 0.0 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase CBF PF03914.17 ELR22255.1 - 2.1e-09 37.7 0.1 2.1e-09 37.7 0.1 2.3 2 1 0 2 2 2 1 CBF/Mak21 family Metallophos PF00149.28 ELR22256.1 - 1.1e-06 29.3 0.0 1.3e-06 29.1 0.0 1.0 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase DUF5457 PF17540.2 ELR22256.1 - 0.092 12.9 0.0 0.13 12.4 0.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5457) EURL PF06937.11 ELR22257.1 - 0.019 14.4 0.3 0.02 14.3 0.3 1.0 1 0 0 1 1 1 0 EURL protein Vasculin PF15337.6 ELR22257.1 - 0.13 13.1 1.9 0.18 12.7 1.3 1.6 1 1 0 1 1 1 0 Vascular protein family Vasculin-like 1 CENP-B_dimeris PF09026.10 ELR22258.1 - 4.4 7.7 10.7 15 6.1 10.7 1.8 1 0 0 1 1 1 0 Centromere protein B dimerisation domain DnaJ PF00226.31 ELR22259.1 - 5e-18 65.0 0.6 1e-17 64.0 0.6 1.6 1 0 0 1 1 1 1 DnaJ domain Ribosomal_60s PF00428.19 ELR22259.1 - 0.03 14.9 2.1 0.03 14.9 2.1 2.0 2 0 0 2 2 2 0 60s Acidic ribosomal protein Peptidase_S49_N PF08496.10 ELR22259.1 - 0.78 9.8 4.4 0.27 11.3 0.3 2.0 2 0 0 2 2 2 0 Peptidase family S49 N-terminal LicD PF04991.13 ELR22260.1 - 9.6e-23 81.5 0.0 8.9e-15 55.4 0.0 2.1 1 1 1 2 2 2 2 LicD family EF-hand_6 PF13405.6 ELR22261.1 - 2.5e-10 39.4 0.3 0.00079 19.2 0.0 2.9 2 1 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.6 ELR22261.1 - 1.4e-09 38.3 0.2 0.00059 20.2 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 ELR22261.1 - 3.2e-07 29.4 0.0 0.034 13.7 0.0 2.7 3 0 0 3 3 3 2 EF hand EFhand_Ca_insen PF08726.10 ELR22261.1 - 0.0077 16.3 0.0 0.067 13.3 0.0 2.4 2 1 0 2 2 2 1 Ca2+ insensitive EF hand EF-hand_8 PF13833.6 ELR22261.1 - 0.039 13.8 0.1 8.9 6.3 0.0 3.0 2 1 1 3 3 3 0 EF-hand domain pair PhetRS_B1 PF18262.1 ELR22261.1 - 0.063 13.5 0.0 0.82 9.9 0.0 2.2 2 0 0 2 2 2 0 Phe-tRNA synthetase beta subunit B1 domain Caleosin PF05042.13 ELR22261.1 - 0.073 13.0 0.0 0.14 12.0 0.0 1.6 1 1 0 1 1 1 0 Caleosin related protein EF-hand_9 PF14658.6 ELR22261.1 - 0.081 13.3 0.0 9.4 6.7 0.0 2.2 2 0 0 2 2 2 0 EF-hand domain zf-U11-48K PF05253.12 ELR22262.1 - 5.8e-09 35.7 2.0 1.2e-08 34.6 2.0 1.6 1 0 0 1 1 1 1 U11-48K-like CHHC zinc finger PMM PF03332.13 ELR22264.1 - 5.6e-69 232.3 0.4 1.3e-68 231.1 0.4 1.5 1 1 0 1 1 1 1 Eukaryotic phosphomannomutase Hydrolase_3 PF08282.12 ELR22264.1 - 3.9e-06 26.8 0.0 0.044 13.5 0.0 2.1 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase S6PP PF05116.13 ELR22264.1 - 0.0024 17.4 0.0 0.15 11.5 0.0 2.1 2 0 0 2 2 2 2 Sucrose-6F-phosphate phosphohydrolase Brix PF04427.18 ELR22265.1 - 6.9e-36 124.2 0.7 8.7e-36 123.8 0.7 1.1 1 0 0 1 1 1 1 Brix domain DEAD_2 PF06733.15 ELR22266.1 - 4.1e-05 23.3 0.7 0.034 13.8 0.1 2.5 2 1 1 3 3 3 2 DEAD_2 GOLGA2L5 PF15070.6 ELR22266.1 - 0.0055 15.4 1.1 0.0066 15.2 1.1 1.0 1 0 0 1 1 1 1 Putative golgin subfamily A member 2-like protein 5 DUF2045 PF09741.9 ELR22266.1 - 0.12 11.8 0.0 0.16 11.4 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2045) C-C_Bond_Lyase PF15617.6 ELR22266.1 - 0.16 11.1 0.6 0.21 10.7 0.6 1.1 1 0 0 1 1 1 0 C-C_Bond_Lyase of the TIM-Barrel fold HalX PF08663.10 ELR22266.1 - 0.97 9.8 7.2 6.8 7.1 3.5 2.4 2 0 0 2 2 2 0 HalX domain WRNPLPNID PF15017.6 ELR22269.1 - 0.73 10.8 5.5 1.8 9.5 5.5 1.6 1 0 0 1 1 1 0 Putative WW-binding domain and destruction box Methyltransf_12 PF08242.12 ELR22270.1 - 0.095 13.5 0.0 0.096 13.4 0.0 1.1 1 0 0 1 1 1 0 Methyltransferase domain Ig_Tie2_1 PF10430.9 ELR22270.1 - 0.12 12.8 0.1 0.14 12.6 0.1 1.1 1 0 0 1 1 1 0 Tie-2 Ig-like domain 1 Fcf1 PF04900.12 ELR22271.1 - 3.1e-29 101.3 3.1 1.9e-28 98.8 3.1 2.1 1 1 0 1 1 1 1 Fcf1 PIN_9 PF18477.1 ELR22271.1 - 1.7e-07 31.5 0.0 3.7e-07 30.4 0.0 1.6 1 0 0 1 1 1 1 PIN like domain Crl PF07417.12 ELR22271.1 - 0.077 13.1 0.0 0.21 11.7 0.0 1.7 1 0 0 1 1 1 0 Sigma factor-binding transcriptional regulator Crl Ribosomal_S2 PF00318.20 ELR22272.1 - 0.06 12.6 0.5 0.074 12.3 0.5 1.2 1 0 0 1 1 1 0 Ribosomal protein S2 5_nucleotid PF05761.14 ELR22273.1 - 8.2e-84 282.1 6.5 9.2e-56 189.6 0.0 3.0 1 1 2 3 3 3 3 5' nucleotidase family Tau95 PF09734.9 ELR22274.1 - 0.018 15.9 0.1 0.03 15.1 0.1 1.3 1 0 0 1 1 1 0 RNA polymerase III transcription factor (TF)IIIC subunit HTH domain HNF-1_N PF04814.13 ELR22274.1 - 0.5 10.9 8.4 0.76 10.4 8.4 1.1 1 0 0 1 1 1 0 Hepatocyte nuclear factor 1 (HNF-1), N terminus AAA PF00004.29 ELR22275.1 - 1.9e-49 167.4 0.0 2.5e-34 118.6 0.0 2.4 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 ELR22275.1 - 1.8e-09 38.2 2.4 0.00038 20.9 0.1 3.5 2 2 0 3 3 3 2 AAA ATPase domain AAA_lid_3 PF17862.1 ELR22275.1 - 2.9e-09 36.6 0.0 4.4e-07 29.6 0.0 3.6 4 0 0 4 4 4 1 AAA+ lid domain AAA_22 PF13401.6 ELR22275.1 - 7.2e-09 36.0 3.8 0.04 14.2 0.9 4.3 2 2 1 3 3 3 2 AAA domain AAA_5 PF07728.14 ELR22275.1 - 6.7e-08 32.6 0.7 0.0026 17.7 0.1 2.9 2 2 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 ELR22275.1 - 9.4e-08 32.4 0.0 9.4e-06 25.8 0.0 2.9 2 1 0 2 2 2 1 AAA domain (Cdc48 subfamily) RuvB_N PF05496.12 ELR22275.1 - 1.1e-07 31.8 0.1 0.014 15.1 0.0 3.6 3 0 0 3 3 3 2 Holliday junction DNA helicase RuvB P-loop domain NACHT PF05729.12 ELR22275.1 - 2.6e-06 27.5 3.5 0.021 14.7 0.6 3.4 2 2 0 2 2 2 2 NACHT domain RNA_helicase PF00910.22 ELR22275.1 - 3.4e-06 27.4 0.0 0.011 16.1 0.0 2.6 2 0 0 2 2 2 2 RNA helicase Zeta_toxin PF06414.12 ELR22275.1 - 4.8e-06 26.0 0.1 0.055 12.7 0.0 2.4 2 0 0 2 2 2 2 Zeta toxin Mg_chelatase PF01078.21 ELR22275.1 - 5.1e-06 26.0 0.1 0.0064 15.9 0.1 2.4 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI TIP49 PF06068.13 ELR22275.1 - 9.5e-06 25.0 0.0 0.13 11.4 0.0 2.2 2 0 0 2 2 2 2 TIP49 P-loop domain AAA_33 PF13671.6 ELR22275.1 - 1.1e-05 25.7 0.0 0.016 15.4 0.0 2.7 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.6 ELR22275.1 - 1.2e-05 25.9 0.0 0.094 13.3 0.0 2.6 2 0 0 2 2 2 2 AAA domain Rad17 PF03215.15 ELR22275.1 - 3.4e-05 23.8 0.1 0.17 11.8 0.0 2.9 2 1 1 3 3 3 2 Rad17 P-loop domain TsaE PF02367.17 ELR22275.1 - 5.8e-05 23.1 0.0 0.23 11.5 0.0 2.5 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE Viral_helicase1 PF01443.18 ELR22275.1 - 5.9e-05 22.9 0.1 0.019 14.7 0.0 2.8 2 1 1 3 3 3 1 Viral (Superfamily 1) RNA helicase Sigma54_activat PF00158.26 ELR22275.1 - 6.2e-05 22.8 0.0 0.095 12.4 0.0 2.5 2 0 0 2 2 2 2 Sigma-54 interaction domain AAA_3 PF07726.11 ELR22275.1 - 6.3e-05 22.8 0.1 0.21 11.4 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) ATPase PF06745.13 ELR22275.1 - 9.9e-05 21.8 0.3 0.049 13.0 0.0 3.0 3 0 0 3 3 2 1 KaiC AAA_14 PF13173.6 ELR22275.1 - 0.0001 22.3 0.0 0.016 15.2 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_24 PF13479.6 ELR22275.1 - 0.00022 21.0 0.0 0.79 9.4 0.0 2.9 2 1 0 2 2 2 2 AAA domain AAA_28 PF13521.6 ELR22275.1 - 0.00038 20.8 0.0 0.23 11.7 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_25 PF13481.6 ELR22275.1 - 0.00054 19.6 1.4 1.1 8.8 0.2 3.4 3 1 0 3 3 3 2 AAA domain AAA_17 PF13207.6 ELR22275.1 - 0.00087 19.7 0.7 1.8 9.0 0.0 3.0 3 0 0 3 3 2 1 AAA domain AAA_7 PF12775.7 ELR22275.1 - 0.0009 18.8 0.3 0.81 9.2 0.0 2.9 3 0 0 3 3 3 1 P-loop containing dynein motor region IstB_IS21 PF01695.17 ELR22275.1 - 0.0023 17.7 0.0 4.2 7.1 0.0 3.1 2 1 0 3 3 3 0 IstB-like ATP binding protein DUF2075 PF09848.9 ELR22275.1 - 0.0028 17.0 0.2 1.2 8.3 0.2 2.5 2 1 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) Sigma54_activ_2 PF14532.6 ELR22275.1 - 0.003 17.7 0.0 1.1 9.4 0.0 2.8 2 0 0 2 2 2 1 Sigma-54 interaction domain NB-ARC PF00931.22 ELR22275.1 - 0.0033 16.7 0.1 0.53 9.4 0.0 2.7 3 0 0 3 3 3 1 NB-ARC domain SKI PF01202.22 ELR22275.1 - 0.0036 17.5 0.8 1.7 8.8 0.0 2.4 2 0 0 2 2 2 1 Shikimate kinase AAA_19 PF13245.6 ELR22275.1 - 0.0073 16.7 0.6 0.8 10.0 0.1 2.6 2 1 0 2 2 2 1 AAA domain ATP-synt_ab PF00006.25 ELR22275.1 - 0.0095 15.6 0.0 0.027 14.2 0.0 1.8 1 1 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain Cytidylate_kin2 PF13189.6 ELR22275.1 - 0.0098 16.0 0.0 7.8 6.6 0.0 2.7 2 0 0 2 2 2 0 Cytidylate kinase-like family AAA_30 PF13604.6 ELR22275.1 - 0.011 15.5 0.3 2.6 7.7 0.0 3.1 3 0 0 3 3 3 0 AAA domain ResIII PF04851.15 ELR22275.1 - 0.012 15.7 0.1 1.4 8.9 0.0 2.9 2 1 0 3 3 3 0 Type III restriction enzyme, res subunit ABC_tran PF00005.27 ELR22275.1 - 0.016 15.7 0.1 3.1 8.3 0.0 2.6 2 0 0 2 2 2 0 ABC transporter NTPase_1 PF03266.15 ELR22275.1 - 0.023 14.6 1.3 0.78 9.6 0.1 3.2 4 0 0 4 4 3 0 NTPase PhoH PF02562.16 ELR22275.1 - 0.039 13.4 0.1 4.7 6.6 0.0 2.7 2 0 0 2 2 2 0 PhoH-like protein AAA_11 PF13086.6 ELR22275.1 - 0.051 13.4 0.0 11 5.7 0.0 2.4 2 0 0 2 2 2 0 AAA domain KTI12 PF08433.10 ELR22275.1 - 0.055 12.9 0.0 0.62 9.5 0.0 2.3 2 0 0 2 2 2 0 Chromatin associated protein KTI12 SRP54 PF00448.22 ELR22275.1 - 0.058 13.0 2.4 1.2 8.8 0.1 3.2 3 0 0 3 3 3 0 SRP54-type protein, GTPase domain KAP_NTPase PF07693.14 ELR22275.1 - 0.065 12.5 0.0 27 3.9 0.0 3.2 3 1 0 3 3 3 0 KAP family P-loop domain Hydin_ADK PF17213.3 ELR22275.1 - 0.08 13.2 0.4 1.7 8.9 0.2 2.2 2 0 0 2 2 2 0 Hydin Adenylate kinase-like domain TniB PF05621.11 ELR22275.1 - 0.087 12.2 0.8 6.7 6.1 0.2 3.7 4 1 0 4 4 3 0 Bacterial TniB protein DAP3 PF10236.9 ELR22275.1 - 0.11 11.7 0.0 4.8 6.3 0.0 2.3 2 0 0 2 2 2 0 Mitochondrial ribosomal death-associated protein 3 DUF815 PF05673.13 ELR22275.1 - 0.16 11.1 0.0 6.5 5.8 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF815) DEAD PF00270.29 ELR22275.1 - 0.23 11.2 1.9 13 5.5 0.2 3.8 2 2 1 3 3 3 0 DEAD/DEAH box helicase CDC48_2 PF02933.17 ELR22276.1 - 3.6e-06 26.7 0.0 7.7e-06 25.6 0.0 1.6 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), domain 2 CDC48_N PF02359.18 ELR22276.1 - 0.0056 16.8 0.0 0.011 15.9 0.0 1.5 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), N-terminal domain Ferritin PF00210.24 ELR22278.1 - 3.9e-12 46.3 0.0 5.1e-12 45.9 0.0 1.1 1 0 0 1 1 1 1 Ferritin-like domain Ependymin PF00811.18 ELR22279.1 - 0.0022 18.2 0.1 0.0038 17.5 0.1 1.3 1 0 0 1 1 1 1 Ependymin Xin PF08043.12 ELR22279.1 - 0.021 14.4 0.1 0.042 13.5 0.1 1.5 1 0 0 1 1 1 0 Xin repeat Voltage_CLC PF00654.20 ELR22280.1 - 1.1e-87 294.6 22.9 5e-85 285.8 18.1 2.9 1 1 1 2 2 2 2 Voltage gated chloride channel CBS PF00571.28 ELR22280.1 - 3.1e-12 46.7 0.1 7.4e-08 32.7 0.0 2.7 2 0 0 2 2 2 2 CBS domain TAT_signal PF10518.9 ELR22280.1 - 0.00072 19.3 1.0 0.00072 19.3 1.0 2.3 3 0 0 3 3 3 1 TAT (twin-arginine translocation) pathway signal sequence UCR_Fe-S_N PF10399.9 ELR22280.1 - 0.22 10.9 1.3 0.8 9.1 1.3 1.9 1 0 0 1 1 1 0 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal RCC1 PF00415.18 ELR22281.1 - 3.5e-28 98.0 6.2 3.7e-11 43.5 0.2 6.2 6 0 0 6 6 6 4 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 ELR22281.1 - 9.4e-23 79.5 12.2 4.5e-09 35.9 0.6 4.3 5 0 0 5 5 5 3 Regulator of chromosome condensation (RCC1) repeat Pkinase PF00069.25 ELR22281.1 - 2.9e-17 62.9 0.0 5.2e-17 62.1 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR22281.1 - 1e-12 47.9 0.0 4.9e-12 45.7 0.0 2.1 2 0 0 2 2 2 1 Protein tyrosine kinase DUF1455 PF07306.11 ELR22281.1 - 0.00042 20.3 5.0 0.0015 18.5 5.0 1.9 1 0 0 1 1 1 1 Protein of unknown function (DUF1455) ASH PF15780.5 ELR22281.1 - 0.042 14.0 0.0 0.1 12.8 0.0 1.6 1 0 0 1 1 1 0 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin Ribosomal_L9_C PF03948.14 ELR22281.1 - 0.11 13.0 0.0 0.27 11.7 0.0 1.6 1 0 0 1 1 1 0 Ribosomal protein L9, C-terminal domain GARS_A PF01071.19 ELR22281.1 - 0.13 12.0 0.1 0.73 9.6 0.0 2.1 1 1 1 2 2 2 0 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain Pkinase PF00069.25 ELR22282.1 - 1.1e-46 159.3 0.0 1.4e-46 159.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR22282.1 - 2.8e-36 125.1 0.0 3.4e-36 124.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 ELR22282.1 - 0.00072 18.4 0.0 0.001 17.9 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Serpin PF00079.20 ELR22284.1 - 2.5e-56 191.6 0.0 3.3e-56 191.2 0.0 1.1 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Cellulase PF00150.18 ELR22285.1 - 2.3e-29 102.7 0.0 4.1e-29 101.9 0.0 1.3 1 1 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) Glyco_hydro_5_C PF18564.1 ELR22285.1 - 2e-14 53.9 0.3 3.3e-14 53.2 0.3 1.4 1 0 0 1 1 1 1 Glycoside hydrolase family 5 C-terminal domain WD40 PF00400.32 ELR22286.1 - 5.5e-17 61.8 8.0 2.3e-06 28.2 0.7 5.2 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ELR22286.1 - 3.6e-07 30.4 0.6 0.078 13.3 0.1 4.1 2 1 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain F-box-like PF12937.7 ELR22286.1 - 0.0061 16.4 0.4 0.0061 16.4 0.4 2.0 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 ELR22286.1 - 0.017 15.0 0.6 0.047 13.6 0.6 1.8 1 0 0 1 1 1 0 F-box domain Nup160 PF11715.8 ELR22286.1 - 0.02 13.5 0.1 0.35 9.5 0.0 2.2 2 0 0 2 2 2 0 Nucleoporin Nup120/160 zf-RING_2 PF13639.6 ELR22287.1 - 4.5e-13 49.3 5.0 5.8e-13 48.9 5.0 1.2 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 ELR22287.1 - 1.5e-11 43.9 4.9 2e-11 43.5 4.9 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 ELR22287.1 - 1.7e-09 37.2 1.8 1.7e-09 37.2 1.8 1.9 2 0 0 2 2 2 1 RING-like zinc finger zf-C3HC4 PF00097.25 ELR22287.1 - 8.7e-09 35.1 4.8 1.2e-08 34.7 4.8 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 ELR22287.1 - 1.2e-08 35.1 6.4 5e-08 33.1 6.4 1.8 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_UBOX PF13445.6 ELR22287.1 - 8.4e-08 32.1 6.3 7.6e-07 29.1 1.0 2.2 2 0 0 2 2 2 1 RING-type zinc-finger zf-RING_5 PF14634.6 ELR22287.1 - 6.1e-07 29.3 3.1 8e-07 28.9 3.1 1.2 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 ELR22287.1 - 6.5e-06 25.9 1.7 8.6e-06 25.5 1.7 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 ELR22287.1 - 5.6e-05 23.1 1.2 8.5e-05 22.5 1.2 1.3 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger Zn_ribbon_17 PF17120.5 ELR22287.1 - 9e-05 22.0 3.0 0.00017 21.1 3.1 1.4 1 1 0 1 1 1 1 Zinc-ribbon, C4HC2 type RINGv PF12906.7 ELR22287.1 - 0.00065 19.8 3.0 0.0015 18.6 3.0 1.6 1 1 0 1 1 1 1 RING-variant domain zf-C3H2C3 PF17122.5 ELR22287.1 - 0.0083 16.1 2.6 0.0083 16.1 2.6 2.0 2 1 0 2 2 1 1 Zinc-finger FANCL_C PF11793.8 ELR22287.1 - 0.014 15.6 6.9 0.18 12.0 6.9 2.4 1 1 0 1 1 1 0 FANCL C-terminal domain Prok-RING_4 PF14447.6 ELR22287.1 - 0.018 14.9 4.2 0.062 13.2 4.5 1.7 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 zinc_ribbon_16 PF17034.5 ELR22287.1 - 0.03 14.5 2.7 0.059 13.6 0.6 1.9 1 1 1 2 2 2 0 Zinc-ribbon like family PHD PF00628.29 ELR22287.1 - 0.05 13.5 4.1 0.098 12.6 4.1 1.5 1 1 0 1 1 1 0 PHD-finger Zf_RING PF16744.5 ELR22287.1 - 0.055 13.6 3.5 0.25 11.5 0.9 2.1 1 1 1 2 2 2 0 KIAA1045 RING finger DUF5466 PF17554.2 ELR22287.1 - 0.069 13.4 0.0 0.1 12.8 0.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5466) CarbpepA_inh PF02977.15 ELR22287.1 - 0.18 11.6 4.3 0.098 12.5 1.1 2.2 2 1 0 2 2 2 0 Carboxypeptidase A inhibitor zf-C3HC4_4 PF15227.6 ELR22287.1 - 7.3 6.8 8.8 84 3.4 9.1 2.4 1 1 1 2 2 2 0 zinc finger of C3HC4-type, RING Glyco_hydro_5_C PF18564.1 ELR22288.1 - 4.9e-09 36.6 0.1 5.7e-09 36.4 0.1 1.1 1 0 0 1 1 1 1 Glycoside hydrolase family 5 C-terminal domain NOC3p PF07540.11 ELR22289.1 - 6.3e-30 103.5 0.9 6.3e-30 103.5 0.9 3.0 4 0 0 4 4 4 1 Nucleolar complex-associated protein CBF PF03914.17 ELR22289.1 - 9.9e-19 68.0 0.5 9.9e-19 68.0 0.5 3.2 3 1 0 3 3 3 1 CBF/Mak21 family Maf PF02545.14 ELR22290.1 - 4.1e-38 130.8 0.0 4.7e-38 130.7 0.0 1.0 1 0 0 1 1 1 1 Maf-like protein Ifi-6-16 PF06140.13 ELR22291.1 - 1.5e-05 24.8 17.8 1.9e-05 24.5 17.8 1.2 1 0 0 1 1 1 1 Interferon-induced 6-16 family Glyco_hydro_3_C PF01915.22 ELR22292.1 - 4.2e-45 154.2 0.0 5.3e-45 153.9 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Glyco_hydro_3 PF00933.21 ELR22292.1 - 1e-25 90.8 0.0 1.6e-25 90.1 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Fn3-like PF14310.6 ELR22292.1 - 7.5e-22 77.2 0.4 1.7e-21 76.1 0.4 1.6 1 0 0 1 1 1 1 Fibronectin type III-like domain CARDB PF07705.11 ELR22292.1 - 0.021 15.1 0.1 0.076 13.3 0.0 2.0 2 0 0 2 2 2 0 CARDB Ras PF00071.22 ELR22293.1 - 9.3e-19 67.6 0.0 2.9e-18 66.0 0.0 1.7 2 0 0 2 2 2 1 Ras family F-box-like PF12937.7 ELR22293.1 - 0.022 14.6 0.5 0.044 13.7 0.5 1.5 1 0 0 1 1 1 0 F-box-like Roc PF08477.13 ELR22293.1 - 0.068 13.4 0.0 0.52 10.5 0.0 2.1 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase LRR_8 PF13855.6 ELR22294.1 - 8.3e-37 124.8 31.2 3.7e-12 45.8 0.3 7.7 5 2 3 8 8 8 8 Leucine rich repeat LRR_4 PF12799.7 ELR22294.1 - 3.8e-29 100.2 33.7 1.4e-06 28.5 0.2 8.3 6 2 3 9 9 9 9 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 ELR22294.1 - 9.9e-09 34.6 29.4 1 10.1 0.0 10.9 10 2 1 11 11 11 4 Leucine Rich Repeat LRR_6 PF13516.6 ELR22294.1 - 2.4e-08 33.4 33.0 0.24 11.6 0.1 11.4 12 0 0 12 12 12 3 Leucine Rich repeat LRR_9 PF14580.6 ELR22294.1 - 0.01 15.3 7.4 1.1 8.8 3.0 3.6 3 1 2 5 5 5 0 Leucine-rich repeat LRRNT PF01462.18 ELR22294.1 - 0.13 11.9 2.3 11 5.8 0.1 4.2 4 0 0 4 4 4 0 Leucine rich repeat N-terminal domain SERTA PF06031.13 ELR22294.1 - 0.4 10.4 4.2 12 5.6 0.2 3.5 3 0 0 3 3 3 0 SERTA motif SapB_1 PF05184.15 ELR22296.1 - 3.9e-18 65.1 0.7 8.5e-09 35.3 0.2 2.5 2 0 0 2 2 2 2 Saposin-like type B, region 1 SapB_2 PF03489.17 ELR22296.1 - 2.4e-17 62.7 1.3 8.3e-08 32.2 0.7 2.8 2 0 0 2 2 2 2 Saposin-like type B, region 2 Uteroglobin PF01099.17 ELR22296.1 - 0.094 13.1 1.6 3.9 7.9 0.1 3.1 2 1 1 3 3 3 0 Uteroglobin family Pkinase_Tyr PF07714.17 ELR22297.1 - 8e-43 146.6 0.0 1.1e-42 146.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ELR22297.1 - 3.3e-39 134.8 0.0 4.5e-39 134.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain FRG1 PF06229.12 ELR22297.1 - 5.4e-05 23.0 0.0 0.53 10.0 0.0 2.8 3 1 0 3 3 3 2 FRG1-like domain Kdo PF06293.14 ELR22297.1 - 0.00074 18.9 0.0 0.0013 18.1 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 ELR22297.1 - 0.0091 15.0 0.0 0.016 14.2 0.0 1.3 1 0 0 1 1 1 1 Haspin like kinase domain Fascin PF06268.13 ELR22297.1 - 0.063 13.5 0.0 0.37 11.0 0.0 2.2 1 1 0 1 1 1 0 Fascin domain adh_short PF00106.25 ELR22298.1 - 5.2e-16 58.7 0.2 6.5e-16 58.4 0.2 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ELR22298.1 - 3.1e-11 43.3 0.9 4.1e-11 42.9 0.9 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ELR22298.1 - 4e-06 26.8 0.3 7.1e-06 26.0 0.3 1.3 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.6 ELR22298.1 - 0.00026 20.9 0.8 0.00029 20.8 0.8 1.2 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 ELR22298.1 - 0.0036 16.8 0.1 0.0041 16.6 0.1 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.17 ELR22298.1 - 0.014 14.5 0.2 0.019 14.1 0.2 1.1 1 0 0 1 1 1 0 RmlD substrate binding domain NmrA PF05368.13 ELR22298.1 - 0.058 12.9 0.5 0.073 12.6 0.5 1.1 1 0 0 1 1 1 0 NmrA-like family RINGv PF12906.7 ELR22298.1 - 0.17 12.0 0.9 3.3 7.9 0.3 2.2 1 1 1 2 2 2 0 RING-variant domain Esterase PF00756.20 ELR22299.1 - 1.7e-25 90.1 0.1 2.7e-25 89.5 0.1 1.3 1 1 0 1 1 1 1 Putative esterase Peptidase_S9 PF00326.21 ELR22299.1 - 0.03 13.8 0.0 0.055 12.9 0.0 1.4 1 0 0 1 1 1 0 Prolyl oligopeptidase family Hydrolase_4 PF12146.8 ELR22299.1 - 0.041 13.1 0.1 0.06 12.6 0.1 1.2 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Ribosomal_L1 PF00687.21 ELR22300.1 - 1.4e-21 77.2 0.0 1.6e-21 77.0 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family Acyl-CoA_dh_1 PF00441.24 ELR22301.1 - 9e-44 149.3 0.5 8.8e-43 146.1 0.1 2.2 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.16 ELR22301.1 - 1.8e-32 112.3 0.1 5.9e-32 110.7 0.0 1.9 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.19 ELR22301.1 - 1.7e-25 89.1 0.0 3.9e-25 87.9 0.0 1.7 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.11 ELR22301.1 - 2.3e-12 47.3 0.0 6.2e-12 45.9 0.0 1.8 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Gluconate_2-dh3 PF13618.6 ELR22301.1 - 0.17 12.1 0.1 0.59 10.4 0.0 1.8 2 0 0 2 2 2 0 Gluconate 2-dehydrogenase subunit 3 Pan_kinase PF03309.14 ELR22302.1 - 1.4e-20 74.0 0.0 6.7e-20 71.8 0.0 1.9 1 1 0 1 1 1 1 Type III pantothenate kinase EBP PF05241.12 ELR22303.1 - 3e-58 196.2 10.3 3.5e-58 196.0 10.3 1.1 1 0 0 1 1 1 1 Emopamil binding protein Peptidase_U4 PF03419.13 ELR22303.1 - 0.00079 18.8 1.0 0.00079 18.8 1.0 1.5 2 0 0 2 2 2 1 Sporulation factor SpoIIGA Carot_N PF09150.10 ELR22303.1 - 0.042 13.7 0.1 0.15 12.0 0.0 1.8 2 0 0 2 2 2 0 Orange carotenoid protein, N-terminal Pho86 PF11124.8 ELR22303.1 - 0.077 12.4 0.1 0.11 11.9 0.1 1.2 1 0 0 1 1 1 0 Inorganic phosphate transporter Pho86 Pkinase PF00069.25 ELR22304.1 - 1.4e-68 231.1 0.0 9.7e-64 215.3 0.0 2.2 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ELR22304.1 - 3.7e-44 151.0 0.0 5.6e-44 150.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase DUF3543 PF12063.8 ELR22304.1 - 6.6e-14 51.9 6.5 3.5e-12 46.3 2.6 2.8 1 1 1 2 2 2 2 Domain of unknown function (DUF3543) Kdo PF06293.14 ELR22304.1 - 0.00033 20.1 0.5 0.00079 18.8 0.1 1.8 2 1 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 ELR22304.1 - 0.0011 17.8 0.0 0.0018 17.1 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Phage_int_SAM_1 PF02899.17 ELR22304.1 - 0.003 17.8 0.8 0.01 16.1 0.1 2.2 2 0 0 2 2 2 1 Phage integrase, N-terminal SAM-like domain APH PF01636.23 ELR22304.1 - 0.0047 16.9 0.0 0.016 15.1 0.0 1.8 1 1 0 1 1 1 1 Phosphotransferase enzyme family Phage_int_SAM_5 PF13102.6 ELR22304.1 - 0.044 14.1 0.0 0.12 12.7 0.0 1.7 1 0 0 1 1 1 0 Phage integrase SAM-like domain YrbL-PhoP_reg PF10707.9 ELR22304.1 - 0.051 13.1 0.1 0.34 10.4 0.0 2.3 3 0 0 3 3 3 0 PhoP regulatory network protein YrbL MIT PF04212.18 ELR22304.1 - 2 8.5 8.8 1.2 9.2 0.1 3.5 3 1 0 3 3 3 0 MIT (microtubule interacting and transport) domain COMM_domain PF07258.14 ELR22305.1 - 1.4e-13 50.8 0.0 1.5e-13 50.6 0.0 1.0 1 0 0 1 1 1 1 COMM domain MIT PF04212.18 ELR22306.1 - 5.2e-09 36.0 1.9 5.2e-09 36.0 1.9 2.5 2 0 0 2 2 2 1 MIT (microtubule interacting and transport) domain Raftlin PF15250.6 ELR22306.1 - 0.16 10.7 4.0 0.21 10.3 4.0 1.1 1 0 0 1 1 1 0 Raftlin DUF3827 PF12877.7 ELR22306.1 - 1.4 7.2 6.5 1.8 6.8 6.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3827) LBP_BPI_CETP PF01273.25 ELR22307.1 - 6.3e-08 32.4 1.3 3.2e-07 30.1 0.8 2.4 2 0 0 2 2 2 1 LBP / BPI / CETP family, N-terminal domain PqiA PF04403.13 ELR22307.1 - 1.1e-06 28.6 17.0 4.2e-06 26.7 9.2 3.2 2 1 0 2 2 2 2 Paraquat-inducible protein A Dsl1_N PF11988.8 ELR22307.1 - 0.086 11.8 0.3 0.18 10.8 0.1 1.5 2 0 0 2 2 2 0 Retrograde transport protein Dsl1 N terminal Pkinase PF00069.25 ELR22308.1 - 9.3e-72 241.5 0.0 1.4e-71 241.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR22308.1 - 5.5e-49 166.8 0.0 7.8e-49 166.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase DUF3543 PF12063.8 ELR22308.1 - 3.9e-06 26.4 0.6 9.7e-06 25.1 0.6 1.6 1 1 0 1 1 1 1 Domain of unknown function (DUF3543) Pkinase_fungal PF17667.1 ELR22308.1 - 0.00056 18.8 0.0 0.00091 18.1 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 ELR22308.1 - 0.0048 16.3 0.4 0.011 15.2 0.1 1.8 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 ELR22308.1 - 0.0052 16.7 0.0 0.012 15.5 0.0 1.6 1 0 0 1 1 1 1 Phosphotransferase enzyme family YrbL-PhoP_reg PF10707.9 ELR22308.1 - 0.042 13.4 0.0 0.68 9.4 0.0 2.3 1 1 0 1 1 1 0 PhoP regulatory network protein YrbL Phage_int_SAM_5 PF13102.6 ELR22308.1 - 0.18 12.2 0.0 0.45 10.9 0.0 1.6 1 0 0 1 1 1 0 Phage integrase SAM-like domain Kelch_3 PF13415.6 ELR22309.1 - 5.5e-05 23.4 0.5 1.4 9.3 0.0 3.7 3 0 0 3 3 3 2 Galactose oxidase, central domain Kelch_6 PF13964.6 ELR22309.1 - 0.0017 18.6 0.1 0.72 10.2 0.0 4.0 4 1 1 5 5 5 1 Kelch motif DUF1668 PF07893.13 ELR22309.1 - 0.01 15.2 0.6 0.17 11.2 0.0 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF1668) Kelch_4 PF13418.6 ELR22309.1 - 0.02 14.9 3.7 4.3 7.4 0.4 4.3 4 1 0 4 4 4 0 Galactose oxidase, central domain DUF5074 PF16819.5 ELR22309.1 - 0.12 12.5 0.6 17 5.5 0.4 2.7 2 2 0 2 2 2 0 Domain of unknown function (DUF5074) Kelch_2 PF07646.15 ELR22309.1 - 0.24 11.5 0.1 0.24 11.5 0.1 4.0 3 2 0 3 3 3 0 Kelch motif Kelch_1 PF01344.25 ELR22309.1 - 6.8 6.4 13.9 3 7.5 0.3 5.0 5 1 0 5 5 5 0 Kelch motif CBS PF00571.28 ELR22312.1 - 3e-27 94.8 0.6 2e-12 47.3 0.2 4.7 4 1 1 5 5 5 4 CBS domain Rep_fac_C PF08542.11 ELR22313.1 - 4.8e-15 55.7 0.0 1.3e-14 54.3 0.0 1.7 1 0 0 1 1 1 1 Replication factor C C-terminal domain AAA PF00004.29 ELR22313.1 - 1.8e-08 34.9 0.1 7.6e-08 32.9 0.0 2.0 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Rad17 PF03215.15 ELR22313.1 - 1.9e-07 31.2 0.0 3.4e-07 30.4 0.0 1.4 1 0 0 1 1 1 1 Rad17 P-loop domain RuvB_N PF05496.12 ELR22313.1 - 1.8e-05 24.5 0.0 3.8e-05 23.5 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_assoc_2 PF16193.5 ELR22313.1 - 2.2e-05 24.7 0.0 5.9e-05 23.3 0.0 1.8 1 0 0 1 1 1 1 AAA C-terminal domain AAA_16 PF13191.6 ELR22313.1 - 9.8e-05 22.8 0.1 0.00035 21.0 0.0 1.7 1 1 0 2 2 2 1 AAA ATPase domain AAA_11 PF13086.6 ELR22313.1 - 0.00013 21.8 0.0 0.00032 20.6 0.0 1.8 1 1 0 1 1 1 1 AAA domain DNA_pol3_delta2 PF13177.6 ELR22313.1 - 0.00055 19.7 0.0 0.18 11.6 0.0 2.3 2 0 0 2 2 2 1 DNA polymerase III, delta subunit AAA_22 PF13401.6 ELR22313.1 - 0.003 17.8 0.0 0.0062 16.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain ResIII PF04851.15 ELR22313.1 - 0.0039 17.2 0.0 0.007 16.4 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Mg_chelatase PF01078.21 ELR22313.1 - 0.0051 16.2 0.0 0.0082 15.5 0.0 1.4 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI IstB_IS21 PF01695.17 ELR22313.1 - 0.0058 16.4 0.0 0.011 15.5 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_24 PF13479.6 ELR22313.1 - 0.0094 15.7 0.0 0.02 14.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain DUF815 PF05673.13 ELR22313.1 - 0.0096 15.1 0.0 0.015 14.5 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_25 PF13481.6 ELR22313.1 - 0.013 15.1 0.0 0.19 11.3 0.0 2.4 3 0 0 3 3 3 0 AAA domain AAA_5 PF07728.14 ELR22313.1 - 0.014 15.3 0.0 0.037 14.0 0.0 1.8 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) TIP49 PF06068.13 ELR22313.1 - 0.018 14.3 0.0 0.046 12.9 0.0 1.6 2 0 0 2 2 2 0 TIP49 P-loop domain AAA_19 PF13245.6 ELR22313.1 - 0.036 14.4 0.1 0.058 13.7 0.1 1.6 1 1 0 1 1 1 0 AAA domain PhoH PF02562.16 ELR22313.1 - 0.052 13.0 0.0 0.098 12.1 0.0 1.4 1 0 0 1 1 1 0 PhoH-like protein DNA_pol3_delta PF06144.13 ELR22313.1 - 0.07 12.9 0.0 0.28 11.0 0.0 1.9 2 0 0 2 2 2 0 DNA polymerase III, delta subunit AAA_7 PF12775.7 ELR22313.1 - 0.095 12.2 0.0 0.18 11.3 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region 2OG-FeII_Oxy_2 PF13532.6 ELR22314.1 - 5.2e-30 105.1 0.0 1.2e-29 103.9 0.0 1.6 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily eIF-1a PF01176.19 ELR22315.1 - 0.04 13.7 0.1 0.078 12.8 0.1 1.5 1 0 0 1 1 1 0 Translation initiation factor 1A / IF-1 CENP-B_dimeris PF09026.10 ELR22315.1 - 2.5 8.5 7.8 4.6 7.7 7.8 1.3 1 0 0 1 1 1 0 Centromere protein B dimerisation domain ADP_ribosyl_GH PF03747.14 ELR22316.1 - 2.2e-31 109.7 0.1 4.4e-31 108.7 0.1 1.5 1 1 0 1 1 1 1 ADP-ribosylglycohydrolase Glyco_hydro_16 PF00722.21 ELR22317.1 - 7.5e-08 32.0 0.0 1.6e-07 31.0 0.0 1.5 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 Glyco_hydro_42 PF02449.15 ELR22317.1 - 1.1e-06 28.3 0.0 2e-06 27.4 0.0 1.4 1 0 0 1 1 1 1 Beta-galactosidase EGF_2 PF07974.13 ELR22317.1 - 0.0099 16.2 18.9 0.019 15.3 18.9 1.5 1 0 0 1 1 1 1 EGF-like domain DUF2244 PF10003.9 ELR22319.1 - 0.064 12.9 0.2 4 7.1 0.1 2.2 2 0 0 2 2 2 0 Integral membrane protein (DUF2244) HA PF03457.14 ELR22320.1 - 4.2e-16 59.0 2.5 4.2e-16 59.0 2.5 3.9 4 1 0 4 4 4 1 Helicase associated domain BAR_2 PF10455.9 ELR22320.1 - 0.018 14.2 1.6 0.036 13.2 1.6 1.4 1 0 0 1 1 1 0 Bin/amphiphysin/Rvs domain for vesicular trafficking zf-DBF PF07535.12 ELR22320.1 - 0.24 11.6 0.8 0.57 10.3 0.1 2.0 2 0 0 2 2 2 0 DBF zinc finger APG6_N PF17675.1 ELR22320.1 - 1.3 9.6 37.4 1.9 9.0 5.3 3.7 2 1 1 3 3 3 0 Apg6 coiled-coil region CENP-F_leu_zip PF10473.9 ELR22320.1 - 1.3 9.1 29.0 0.22 11.5 7.8 2.4 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 YqjK PF13997.6 ELR22320.1 - 5.5 7.3 14.2 1.4 9.2 2.0 3.5 3 0 0 3 3 3 0 YqjK-like protein WAP PF00095.21 ELR22321.1 - 3.4 8.1 18.6 7.1 7.1 6.7 2.2 2 0 0 2 2 2 0 WAP-type (Whey Acidic Protein) 'four-disulfide core' Peripla_BP_6 PF13458.6 ELR22322.1 - 2.3e-25 90.0 10.7 2.8e-25 89.7 10.7 1.1 1 0 0 1 1 1 1 Periplasmic binding protein Sel1 PF08238.12 ELR22323.1 - 6e-29 99.8 18.4 4.4e-07 30.4 0.0 6.3 6 0 0 6 6 6 6 Sel1 repeat TPR_6 PF13174.6 ELR22323.1 - 0.0013 19.3 2.2 6.8 7.6 0.1 4.4 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_1 PF00515.28 ELR22323.1 - 0.57 10.1 12.0 17 5.5 0.0 5.8 6 0 0 6 6 6 0 Tetratricopeptide repeat PTEN_C2 PF10409.9 ELR22324.1 - 2.8e-15 56.3 0.1 6.5e-15 55.1 0.1 1.6 1 0 0 1 1 1 1 C2 domain of PTEN tumour-suppressor protein DSPc PF00782.20 ELR22324.1 - 9.6e-08 31.9 0.1 2.3e-07 30.7 0.1 1.6 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 ELR22324.1 - 0.00028 20.5 0.0 0.00054 19.6 0.0 1.5 1 0 0 1 1 1 1 Protein-tyrosine phosphatase PTPlike_phytase PF14566.6 ELR22324.1 - 0.012 15.8 0.0 0.033 14.3 0.0 1.7 1 0 0 1 1 1 0 Inositol hexakisphosphate Y_phosphatase3 PF13350.6 ELR22324.1 - 0.02 14.9 0.0 0.053 13.5 0.0 1.7 1 0 0 1 1 1 0 Tyrosine phosphatase family Mito_carr PF00153.27 ELR22325.1 - 2.6e-46 155.5 3.0 1.7e-16 59.9 0.1 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Beta-lactamase PF00144.24 ELR22325.1 - 0.079 12.2 0.1 0.4 9.9 0.0 1.9 2 0 0 2 2 2 0 Beta-lactamase SKG6 PF08693.10 ELR22326.1 - 0.016 14.6 2.0 0.039 13.4 2.0 1.6 1 0 0 1 1 1 0 Transmembrane alpha-helix domain Tad PF13400.6 ELR22326.1 - 4.5 7.7 13.0 0.39 11.1 6.1 2.6 3 0 0 3 3 3 0 Putative Flp pilus-assembly TadE/G-like CBM49 PF09478.10 ELR22327.1 - 9.2e-33 112.4 3.0 1.1e-14 54.5 0.2 3.1 3 0 0 3 3 3 3 Carbohydrate binding domain CBM49 CBM_2 PF00553.19 ELR22327.1 - 9.2e-09 35.5 10.8 0.00038 20.7 0.7 3.7 3 1 1 4 4 4 2 Cellulose binding domain HhH-GPD PF00730.25 ELR22329.1 - 4.2e-25 88.3 0.0 1.2e-24 86.9 0.0 1.8 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein NUDIX_4 PF14815.6 ELR22329.1 - 1.2e-09 38.1 1.4 4.5e-06 26.6 1.4 3.4 1 1 0 1 1 1 1 NUDIX domain HHH PF00633.23 ELR22329.1 - 9.2e-09 34.7 0.1 2.9e-08 33.2 0.0 2.0 2 0 0 2 2 2 1 Helix-hairpin-helix motif Cdd1 PF11731.8 ELR22329.1 - 0.002 18.3 0.0 0.0049 17.1 0.0 1.6 1 0 0 1 1 1 1 Pathogenicity locus EndIII_4Fe-2S PF10576.9 ELR22329.1 - 0.0092 16.3 8.2 0.0092 16.3 8.2 1.9 2 0 0 2 2 2 1 Iron-sulfur binding domain of endonuclease III DUF4913 PF16259.5 ELR22329.1 - 0.31 11.1 2.8 0.9 9.6 0.5 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4913) CD99L2 PF12301.8 ELR22329.1 - 7.7 6.8 9.3 5.2 7.3 0.6 2.6 2 0 0 2 2 2 0 CD99 antigen like protein 2 F-box-like PF12937.7 ELR22330.1 - 3.9e-06 26.7 0.0 7.4e-06 25.8 0.0 1.5 1 0 0 1 1 1 1 F-box-like CbtB PF09489.10 ELR22330.1 - 0.18 12.0 0.6 0.3 11.2 0.6 1.4 1 0 0 1 1 1 0 Probable cobalt transporter subunit (CbtB) DUF2502 PF10697.9 ELR22330.1 - 0.18 12.1 7.4 0.37 11.2 7.4 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2502) RRM_1 PF00076.22 ELR22331.1 - 5.3e-14 51.8 0.7 4.4e-06 26.4 0.0 3.4 3 1 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 ELR22331.1 - 0.071 13.2 0.0 0.15 12.2 0.0 1.6 1 0 0 1 1 1 0 RNA recognition motif DUF3510 PF12022.8 ELR22332.1 - 2e-32 112.2 0.1 5.8e-32 110.7 0.1 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF3510) COG2 PF06148.11 ELR22332.1 - 9e-06 25.8 3.6 9.9e-06 25.7 0.1 2.9 4 0 0 4 4 4 1 COG (conserved oligomeric Golgi) complex component, COG2 JHD PF17811.1 ELR22332.1 - 0.0087 16.6 0.2 12 6.5 0.0 3.5 3 0 0 3 3 3 1 Jumonji helical domain DUF4085 PF13315.6 ELR22332.1 - 0.038 13.6 0.1 2.7 7.6 0.0 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF4085) HSBP1 PF06825.12 ELR22332.1 - 0.062 13.2 0.0 2.7 7.9 0.0 3.0 3 0 0 3 3 3 0 Heat shock factor binding protein 1 Arm-DNA-bind_3 PF13356.6 ELR22332.1 - 0.08 13.3 0.1 25 5.3 0.1 2.9 2 0 0 2 2 2 0 Arm DNA-binding domain PsbQ PF05757.11 ELR22332.1 - 0.083 12.6 2.4 16 5.1 0.0 3.7 4 0 0 4 4 4 0 Oxygen evolving enhancer protein 3 (PsbQ) Syntaxin_2 PF14523.6 ELR22332.1 - 0.12 12.8 2.2 27 5.2 0.1 3.4 3 0 0 3 3 3 0 Syntaxin-like protein Neuromodulin PF06614.11 ELR22332.1 - 3 8.0 13.1 7 6.8 2.6 2.3 2 0 0 2 2 2 0 Neuromodulin Peptidase_C48 PF02902.19 ELR22333.1 - 5.6e-30 104.8 0.4 2.7e-26 92.7 0.0 3.2 3 1 0 3 3 3 2 Ulp1 protease family, C-terminal catalytic domain CNDH2_C PF16858.5 ELR22333.1 - 0.032 14.1 16.8 0.35 10.7 8.5 2.3 2 0 0 2 2 2 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term SpoIIIAH PF12685.7 ELR22333.1 - 0.082 12.7 7.1 0.48 10.2 0.3 2.4 3 0 0 3 3 3 0 SpoIIIAH-like protein Myc_N PF01056.18 ELR22333.1 - 0.78 9.6 11.2 2.3 8.0 3.7 2.3 2 0 0 2 2 2 0 Myc amino-terminal region Vfa1 PF08432.10 ELR22333.1 - 2.5 8.4 28.3 0.33 11.3 8.0 3.0 3 0 0 3 3 3 0 AAA-ATPase Vps4-associated protein 1 Serinc PF03348.15 ELR22333.1 - 3.2 6.6 6.6 8.5 5.2 2.4 2.1 2 0 0 2 2 2 0 Serine incorporator (Serinc) RXT2_N PF08595.11 ELR22333.1 - 4.4 7.3 20.9 0.86 9.6 4.6 2.6 3 0 0 3 3 3 0 RXT2-like, N-terminal NOA36 PF06524.12 ELR22333.1 - 5.8 6.1 23.0 1.9 7.7 8.6 2.4 2 0 0 2 2 2 0 NOA36 protein DUF2052 PF09747.9 ELR22333.1 - 6.4 6.8 27.4 2 8.5 7.5 3.0 3 0 0 3 3 3 0 Coiled-coil domain containing protein (DUF2052) PPP4R2 PF09184.11 ELR22333.1 - 9.1 5.8 27.7 1.7 8.2 11.5 2.1 2 0 0 2 2 2 0 PPP4R2 Afi1 PF07792.12 ELR22333.1 - 9.3 6.7 21.4 2.4 8.7 2.6 2.9 3 0 0 3 3 3 0 Docking domain of Afi1 for Arf3 in vesicle trafficking MORN PF02493.20 ELR22334.1 - 7.1e-41 135.7 73.0 6.4e-08 32.0 3.7 8.5 8 0 0 8 8 8 8 MORN repeat F-box PF00646.33 ELR22334.1 - 0.06 13.2 0.1 0.13 12.1 0.1 1.6 1 0 0 1 1 1 0 F-box domain Mito_carr PF00153.27 ELR22335.1 - 0.01 15.7 0.0 0.025 14.5 0.0 1.6 1 0 0 1 1 1 0 Mitochondrial carrier protein Lipase_GDSL PF00657.22 ELR22336.1 - 1.8e-09 37.8 0.0 3.3e-09 37.0 0.0 1.4 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase SapB_2 PF03489.17 ELR22336.1 - 2.1e-06 27.7 0.1 6.6e-06 26.1 0.1 2.0 1 0 0 1 1 1 1 Saposin-like type B, region 2 Lipase_GDSL_2 PF13472.6 ELR22336.1 - 0.0032 17.9 0.2 0.0092 16.4 0.2 1.9 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Cu-binding_MopE PF11617.8 ELR22336.1 - 0.0037 17.4 1.0 0.01 16.0 1.0 1.8 1 0 0 1 1 1 1 Putative metal-binding motif FGase PF05013.12 ELR22337.1 - 9.7e-21 75.0 0.3 9.9e-20 71.7 0.3 2.1 1 1 0 1 1 1 1 N-formylglutamate amidohydrolase Mito_carr PF00153.27 ELR22338.1 - 9.8e-62 204.9 0.9 1.7e-20 72.7 0.1 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein SPACA9 PF15120.6 ELR22338.1 - 0.078 12.8 0.0 0.16 11.7 0.0 1.5 1 0 0 1 1 1 0 Sperm acrosome-associated protein 9 Ras PF00071.22 ELR22339.1 - 2.9e-51 173.3 0.1 4.2e-51 172.8 0.1 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR22339.1 - 3.2e-26 91.9 0.1 7.5e-26 90.7 0.1 1.6 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR22339.1 - 3e-07 30.1 0.0 4.2e-07 29.6 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 ELR22339.1 - 2e-05 24.6 0.0 0.19 11.6 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase Gtr1_RagA PF04670.12 ELR22339.1 - 2.2e-05 23.9 0.1 0.00018 21.0 0.1 2.0 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region TniB PF05621.11 ELR22339.1 - 0.0014 18.1 0.0 0.0023 17.4 0.0 1.3 1 0 0 1 1 1 1 Bacterial TniB protein MMR_HSR1 PF01926.23 ELR22339.1 - 0.0019 18.2 0.0 0.0029 17.7 0.0 1.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.10 ELR22339.1 - 0.0059 16.1 0.0 0.009 15.5 0.0 1.4 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Septin PF00735.18 ELR22339.1 - 0.0079 15.5 0.0 0.016 14.5 0.0 1.4 2 0 0 2 2 2 1 Septin AAA_16 PF13191.6 ELR22339.1 - 0.0096 16.3 0.0 0.016 15.6 0.0 1.7 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 ELR22339.1 - 0.024 14.9 0.0 0.053 13.8 0.0 1.9 1 1 0 1 1 1 0 AAA domain AAA_5 PF07728.14 ELR22339.1 - 0.03 14.3 0.0 0.059 13.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) FeoB_N PF02421.18 ELR22339.1 - 0.031 13.8 0.0 1.3 8.5 0.0 2.2 2 0 0 2 2 2 0 Ferrous iron transport protein B PduV-EutP PF10662.9 ELR22339.1 - 0.042 13.6 0.1 0.1 12.4 0.1 1.9 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation AAA_7 PF12775.7 ELR22339.1 - 0.044 13.3 0.0 0.072 12.6 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA PF00004.29 ELR22339.1 - 0.054 13.9 0.0 0.63 10.5 0.0 2.2 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_29 PF13555.6 ELR22339.1 - 0.1 12.3 0.4 0.53 10.1 0.0 2.1 2 0 0 2 2 2 0 P-loop containing region of AAA domain AlcCBM31 PF11606.8 ELR22339.1 - 0.13 12.4 0.0 0.25 11.6 0.0 1.4 1 0 0 1 1 1 0 Family 31 carbohydrate binding protein NACHT PF05729.12 ELR22339.1 - 0.14 12.1 0.0 0.24 11.3 0.0 1.3 1 0 0 1 1 1 0 NACHT domain Myotub-related PF06602.14 ELR22340.1 - 4e-63 213.5 0.0 7.2e-63 212.6 0.0 1.4 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain Pkinase_Tyr PF07714.17 ELR22340.1 - 2.4e-46 158.1 0.0 6.8e-46 156.6 0.0 1.7 2 0 0 2 2 2 1 Protein tyrosine kinase COR PF16095.5 ELR22340.1 - 8e-44 149.8 0.0 1.4e-43 149.0 0.0 1.4 1 0 0 1 1 1 1 C-terminal of Roc, COR, domain Pkinase PF00069.25 ELR22340.1 - 3.8e-39 134.6 1.1 7.2e-39 133.7 0.0 2.0 2 0 0 2 2 1 1 Protein kinase domain LRR_8 PF13855.6 ELR22340.1 - 1.1e-38 130.8 24.6 2e-07 30.7 1.0 6.8 5 1 1 6 6 6 6 Leucine rich repeat LRR_4 PF12799.7 ELR22340.1 - 1.1e-35 121.0 20.1 3.6e-06 27.2 0.3 8.1 7 1 1 8 8 8 7 Leucine Rich repeats (2 copies) Roc PF08477.13 ELR22340.1 - 1.6e-21 76.7 0.0 8.8e-20 71.1 0.0 2.7 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase PH PF00169.29 ELR22340.1 - 1e-13 51.7 0.0 3.9e-13 49.8 0.0 2.0 2 0 0 2 2 2 1 PH domain LRR_1 PF00560.33 ELR22340.1 - 9.6e-10 37.6 21.6 4.4 8.2 0.0 11.8 13 0 0 13 13 12 2 Leucine Rich Repeat Ras PF00071.22 ELR22340.1 - 2.8e-08 33.5 0.0 6.4e-07 29.1 0.0 2.4 1 1 0 1 1 1 1 Ras family LRR_6 PF13516.6 ELR22340.1 - 1.9e-06 27.5 31.5 1.8 8.8 0.2 10.1 11 0 0 11 11 11 2 Leucine Rich repeat LRR_9 PF14580.6 ELR22340.1 - 0.0001 21.8 2.2 0.093 12.2 0.0 3.7 3 1 1 4 4 4 2 Leucine-rich repeat MMR_HSR1 PF01926.23 ELR22340.1 - 0.002 18.2 0.0 0.0064 16.6 0.0 1.9 1 0 0 1 1 1 1 50S ribosome-binding GTPase Ndufs5 PF10200.9 ELR22340.1 - 0.029 14.6 2.8 0.038 14.2 0.1 2.5 2 0 0 2 2 2 0 NADH:ubiquinone oxidoreductase, NDUFS5-15kDa FeoB_N PF02421.18 ELR22340.1 - 0.12 11.9 0.0 0.27 10.8 0.0 1.5 1 0 0 1 1 1 0 Ferrous iron transport protein B Fes1 PF08609.10 ELR22342.1 - 3.3e-13 50.3 3.9 7.3e-13 49.2 1.2 2.6 3 0 0 3 3 3 1 Nucleotide exchange factor Fes1 V-ATPase_H_C PF11698.8 ELR22342.1 - 2e-05 24.7 1.6 0.0023 18.0 0.1 3.0 1 1 1 3 3 3 1 V-ATPase subunit H Arm PF00514.23 ELR22342.1 - 0.0005 20.0 2.3 0.71 10.0 0.0 5.0 4 1 2 6 6 6 1 Armadillo/beta-catenin-like repeat DUF4704 PF15787.5 ELR22342.1 - 0.00057 19.2 0.0 0.0011 18.3 0.0 1.5 1 1 0 1 1 1 1 Domain of unknown function (DUF4704) CDC14 PF08045.11 ELR22342.1 - 0.00095 18.3 0.3 0.088 11.9 0.1 2.1 2 0 0 2 2 2 2 Cell division control protein 14, SIN component Flagellin_N PF00669.20 ELR22342.1 - 0.009 16.1 0.3 0.009 16.1 0.3 1.8 2 0 0 2 2 2 1 Bacterial flagellin N-terminal helical region Atx10homo_assoc PF09759.9 ELR22342.1 - 0.012 15.7 0.1 4 7.5 0.0 3.1 2 1 1 3 3 3 0 Spinocerebellar ataxia type 10 protein domain HEAT_EZ PF13513.6 ELR22342.1 - 0.074 13.6 9.6 0.26 11.8 1.0 4.0 3 1 1 4 4 4 0 HEAT-like repeat HEAT PF02985.22 ELR22342.1 - 0.12 12.7 4.1 4.4 7.8 0.1 3.7 4 0 0 4 4 4 0 HEAT repeat FPL PF09758.9 ELR22342.1 - 0.14 12.2 0.0 4 7.4 0.0 2.4 2 1 0 2 2 2 0 Uncharacterised conserved protein KIP1 PF07765.12 ELR22342.1 - 0.19 11.8 3.7 0.13 12.4 1.4 2.0 2 0 0 2 2 2 0 KIP1-like protein HMG_box PF00505.19 ELR22343.1 - 1.1e-10 41.8 0.3 1.8e-10 41.1 0.3 1.3 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 ELR22343.1 - 4.8e-08 33.5 0.3 9.9e-08 32.5 0.3 1.5 1 0 0 1 1 1 1 HMG-box domain SDA1 PF05285.12 ELR22344.1 - 2.1 7.7 13.9 3.2 7.1 13.9 1.3 1 0 0 1 1 1 0 SDA1 CDC45 PF02724.14 ELR22344.1 - 4 5.6 7.4 4.6 5.4 7.4 1.3 1 0 0 1 1 1 0 CDC45-like protein HMG_box PF00505.19 ELR22345.1 - 4.7e-21 75.0 0.1 5.7e-21 74.7 0.1 1.1 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 ELR22345.1 - 4.4e-16 59.2 1.0 5.3e-16 59.0 1.0 1.1 1 0 0 1 1 1 1 HMG-box domain CHDNT PF08073.12 ELR22345.1 - 0.021 14.7 0.0 0.031 14.2 0.0 1.2 1 0 0 1 1 1 0 CHDNT (NUC034) domain YABBY PF04690.13 ELR22345.1 - 0.054 14.1 0.0 0.071 13.7 0.0 1.2 1 1 0 1 1 1 0 YABBY protein PTPRCAP PF15713.5 ELR22346.1 - 0.0094 16.2 7.0 0.0094 16.2 7.0 3.1 2 1 1 3 3 3 1 Protein tyrosine phosphatase receptor type C-associated DUF2052 PF09747.9 ELR22346.1 - 0.62 10.2 26.1 2.3 8.3 10.4 2.3 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) OCC1 PF15506.6 ELR22346.1 - 3.6 7.8 6.6 0.94 9.7 0.2 2.7 2 0 0 2 2 2 0 OCC1 family FancD2 PF14631.6 ELR22346.1 - 4.3 4.6 8.4 7.1 3.9 8.4 1.2 1 0 0 1 1 1 0 Fanconi anaemia protein FancD2 nuclease DUF2368 PF10166.9 ELR22347.1 - 2.6 7.7 7.0 0.31 10.7 2.4 1.9 2 0 0 2 2 2 0 Uncharacterised conserved protein (DUF2368) Arfaptin PF06456.13 ELR22348.1 - 0.0073 15.9 0.5 0.011 15.3 0.5 1.3 1 0 0 1 1 1 1 Arfaptin-like domain Pkinase PF00069.25 ELR22349.1 - 1.4e-64 218.0 0.0 6.3e-64 215.9 0.0 2.1 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR22349.1 - 1.5e-29 103.1 0.0 2.8e-19 69.4 0.1 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase LIM PF00412.22 ELR22349.1 - 1.4e-12 47.7 4.1 1.4e-12 47.7 4.1 2.1 2 0 0 2 2 2 1 LIM domain Kinase-like PF14531.6 ELR22349.1 - 9.3e-10 38.3 0.1 5.9e-05 22.5 0.0 3.2 3 0 0 3 3 3 2 Kinase-like Pkinase_fungal PF17667.1 ELR22349.1 - 3.5e-06 26.1 0.0 3.5e-06 26.1 0.0 2.5 2 1 0 2 2 1 1 Fungal protein kinase APH PF01636.23 ELR22349.1 - 0.00021 21.3 0.0 0.00039 20.4 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.14 ELR22349.1 - 0.0034 16.8 0.0 0.01 15.2 0.0 1.7 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 ELR22349.1 - 0.013 14.4 0.0 0.013 14.4 0.0 2.3 2 0 0 2 2 2 0 Haspin like kinase domain FTA2 PF13095.6 ELR22349.1 - 0.018 14.7 0.1 4.8 6.8 0.1 2.3 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 RIO1 PF01163.22 ELR22349.1 - 0.038 13.6 0.0 0.087 12.4 0.0 1.5 1 0 0 1 1 1 0 RIO1 family Jas PF16135.5 ELR22349.1 - 0.07 13.3 3.8 0.82 9.9 0.1 2.8 2 0 0 2 2 2 0 TPL-binding domain in jasmonate signalling DUF4428 PF14471.6 ELR22349.1 - 0.12 12.3 2.3 0.32 10.9 1.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4428) DUF2318 PF10080.9 ELR22349.1 - 0.13 12.4 3.8 1.7 8.8 0.4 2.4 2 0 0 2 2 2 0 Predicted membrane protein (DUF2318) Sgf11 PF08209.11 ELR22349.1 - 2 8.0 4.2 0.46 10.1 0.7 1.8 2 0 0 2 2 2 0 Sgf11 (transcriptional regulation protein) TP_methylase PF00590.20 ELR22350.1 - 1.3e-11 44.9 0.0 1.5e-11 44.6 0.0 1.1 1 0 0 1 1 1 1 Tetrapyrrole (Corrin/Porphyrin) Methylases Homeodomain PF00046.29 ELR22351.1 - 2.6e-15 56.0 0.1 7.2e-15 54.6 0.1 1.7 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 ELR22351.1 - 4.2e-05 23.4 0.0 9.7e-05 22.2 0.0 1.6 1 0 0 1 1 1 1 Homeobox KN domain TFIIF_alpha PF05793.12 ELR22351.1 - 0.13 10.9 0.8 0.17 10.4 0.8 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) EF-hand_7 PF13499.6 ELR22352.1 - 4.6e-26 91.1 17.4 1.1e-11 45.0 3.6 2.8 1 1 2 3 3 3 3 EF-hand domain pair EF-hand_6 PF13405.6 ELR22352.1 - 7.7e-24 81.5 14.8 1.7e-08 33.7 0.4 4.0 4 0 0 4 4 4 3 EF-hand domain EF-hand_1 PF00036.32 ELR22352.1 - 1.1e-23 80.9 17.7 2.8e-08 32.7 0.4 4.3 4 0 0 4 4 4 3 EF hand EF-hand_8 PF13833.6 ELR22352.1 - 3.2e-18 65.3 12.5 6.1e-07 29.2 0.2 3.9 4 0 0 4 4 4 3 EF-hand domain pair EF-hand_5 PF13202.6 ELR22352.1 - 5.7e-13 47.7 25.3 7.2e-07 28.4 2.1 4.8 4 2 1 5 5 5 2 EF hand SPARC_Ca_bdg PF10591.9 ELR22352.1 - 4.9e-06 26.8 1.4 0.00055 20.2 0.3 2.2 1 1 1 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_10 PF14788.6 ELR22352.1 - 0.00042 20.1 7.1 0.084 12.8 0.7 3.3 3 0 0 3 3 3 2 EF hand Caleosin PF05042.13 ELR22352.1 - 0.0009 19.2 1.1 6.8 6.6 0.0 3.0 1 1 2 3 3 3 2 Caleosin related protein EF-hand_9 PF14658.6 ELR22352.1 - 0.0019 18.4 0.0 0.47 10.8 0.0 2.2 2 0 0 2 2 2 1 EF-hand domain TerB PF05099.13 ELR22352.1 - 0.0028 17.6 2.5 0.014 15.3 0.6 2.3 1 1 1 2 2 2 2 Tellurite resistance protein TerB EF-hand_14 PF17959.1 ELR22352.1 - 0.0037 17.6 0.2 3 8.2 0.1 2.4 2 1 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.7 ELR22352.1 - 0.024 14.6 3.6 3.1 7.8 0.1 2.9 2 1 1 3 3 3 0 Cytoskeletal-regulatory complex EF hand p25-alpha PF05517.12 ELR22352.1 - 0.055 13.6 3.0 0.27 11.4 3.0 2.1 1 1 0 1 1 1 0 p25-alpha DUF2666 PF10869.8 ELR22352.1 - 0.066 13.4 0.2 6 7.1 0.0 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2666) TPR_20 PF14561.6 ELR22352.1 - 0.11 12.8 0.2 0.38 11.1 0.0 1.9 2 0 0 2 2 2 0 Tetratricopeptide repeat SAP PF02037.27 ELR22352.1 - 0.13 12.1 0.0 1.9 8.4 0.0 2.1 2 0 0 2 2 2 0 SAP domain AAA PF00004.29 ELR22352.1 - 0.18 12.2 0.1 0.31 11.4 0.1 1.3 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) DUF1456 PF07308.13 ELR22352.1 - 0.25 11.7 1.1 44 4.5 0.0 3.0 1 1 3 4 4 4 0 Protein of unknown function (DUF1456) DNA_ligase_IV PF11411.8 ELR22352.1 - 1.6 9.0 5.8 6.9 6.9 0.1 3.4 3 0 0 3 3 3 0 DNA ligase IV PPR_3 PF13812.6 ELR22353.1 - 1.7e-29 101.7 2.5 4.7e-11 42.6 0.0 6.3 3 2 3 6 6 6 5 Pentatricopeptide repeat domain PPR_2 PF13041.6 ELR22353.1 - 2.3e-28 98.1 5.6 1.1e-10 41.5 0.0 6.0 5 1 1 6 6 6 5 PPR repeat family PPR PF01535.20 ELR22353.1 - 3.9e-17 61.2 16.4 1.5e-05 24.9 0.0 7.9 7 1 0 7 7 7 3 PPR repeat PPR_1 PF12854.7 ELR22353.1 - 2.4e-15 55.9 14.1 0.0036 17.0 0.2 7.9 6 2 1 7 7 7 4 PPR repeat PPR_long PF17177.4 ELR22353.1 - 2.2e-13 50.1 0.1 6.2e-10 38.8 0.0 2.5 1 1 2 3 3 3 3 Pentacotripeptide-repeat region of PRORP LIX1 PF14954.6 ELR22353.1 - 0.00071 18.9 0.2 0.013 14.8 0.0 2.6 3 0 0 3 3 3 1 Limb expression 1 Pox_C7_F8A PF03287.14 ELR22354.1 - 0.078 13.0 1.4 0.19 11.7 0.5 1.9 2 1 0 2 2 2 0 Poxvirus C7/F8A protein DUF2383 PF09537.10 ELR22355.1 - 9.9e-35 119.3 0.2 1.3e-34 118.9 0.2 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF2383) 5_3_exonuc_N PF02739.16 ELR22355.1 - 0.051 13.5 0.0 0.079 12.9 0.0 1.3 1 0 0 1 1 1 0 5'-3' exonuclease, N-terminal resolvase-like domain H-kinase_dim PF02895.14 ELR22355.1 - 1 9.8 3.3 0.63 10.5 0.8 2.0 2 2 0 2 2 2 0 Signal transducing histidine kinase, homodimeric domain CH PF00307.31 ELR22356.1 - 3e-21 75.6 0.0 9e-21 74.1 0.0 1.9 1 0 0 1 1 1 1 Calponin homology (CH) domain SR-25 PF10500.9 ELR22356.1 - 0.0057 16.3 39.1 0.0057 16.3 39.1 5.6 4 2 2 6 6 6 1 Nuclear RNA-splicing-associated protein CAMSAP_CH PF11971.8 ELR22356.1 - 0.047 13.5 0.0 0.091 12.6 0.0 1.5 1 0 0 1 1 1 0 CAMSAP CH domain Ala_racemase_N PF01168.20 ELR22357.1 - 4.9e-24 85.2 0.0 6.1e-24 84.9 0.0 1.1 1 0 0 1 1 1 1 Alanine racemase, N-terminal domain LCAT PF02450.15 ELR22358.1 - 5.2e-54 183.9 0.0 2.9e-52 178.2 0.0 2.1 1 1 0 1 1 1 1 Lecithin:cholesterol acyltransferase C2 PF00168.30 ELR22358.1 - 6.7e-37 125.9 0.0 5e-21 74.9 0.0 2.9 3 0 0 3 3 3 2 C2 domain DUF676 PF05057.14 ELR22358.1 - 0.0059 16.1 0.0 0.031 13.8 0.0 1.9 2 0 0 2 2 2 1 Putative serine esterase (DUF676) CEP76-C2 PF15627.6 ELR22358.1 - 0.061 12.9 0.0 0.13 11.8 0.0 1.4 1 0 0 1 1 1 0 CEP76 C2 domain DUF2489 PF10675.9 ELR22358.1 - 0.15 12.0 0.1 0.35 10.8 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2489) Pkinase_Tyr PF07714.17 ELR22359.1 - 3e-13 49.7 0.0 5.6e-13 48.8 0.0 1.4 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ELR22359.1 - 4.6e-07 29.5 0.0 3.1e-06 26.8 0.0 1.9 1 1 0 1 1 1 1 Protein kinase domain DIM PF08194.12 ELR22360.1 - 0.018 15.2 2.6 0.043 14.0 1.1 2.4 2 0 0 2 2 2 0 DIM protein MM_CoA_mutase PF01642.22 ELR22360.1 - 0.096 11.2 0.0 0.25 9.8 0.0 1.6 1 1 1 2 2 2 0 Methylmalonyl-CoA mutase phiKZ_IP PF12699.7 ELR22360.1 - 0.12 11.5 0.1 0.17 11.0 0.1 1.2 1 0 0 1 1 1 0 phiKZ-like phage internal head proteins DAO PF01266.24 ELR22361.1 - 3e-52 178.4 1.2 5.3e-32 111.8 0.1 2.5 1 1 1 2 2 2 2 FAD dependent oxidoreductase Amino_oxidase PF01593.24 ELR22361.1 - 7.2e-06 25.5 0.2 0.14 11.4 0.0 2.9 2 1 1 3 3 3 2 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 ELR22361.1 - 0.0011 19.1 0.0 0.0048 17.1 0.0 2.1 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Baculo_LEF-11 PF06385.12 ELR22361.1 - 0.0019 18.6 0.5 0.57 10.7 0.1 2.3 2 0 0 2 2 2 2 Baculovirus LEF-11 protein HI0933_like PF03486.14 ELR22361.1 - 0.036 12.8 0.0 0.088 11.5 0.0 1.5 2 0 0 2 2 2 0 HI0933-like protein Pyr_redox_2 PF07992.14 ELR22361.1 - 0.043 13.0 0.0 0.53 9.5 0.0 2.4 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase Rtt106 PF08512.12 ELR22361.1 - 0.18 12.2 0.0 23 5.5 0.0 2.3 2 0 0 2 2 2 0 Histone chaperone Rttp106-like RBD-FIP PF09457.10 ELR22361.1 - 0.23 11.4 0.7 39 4.3 0.0 3.0 2 0 0 2 2 2 0 FIP domain CBM49 PF09478.10 ELR22363.1 - 2.3e-32 111.1 8.5 5.8e-17 61.8 0.7 3.1 3 0 0 3 3 3 3 Carbohydrate binding domain CBM49 CBM_2 PF00553.19 ELR22363.1 - 4.5e-11 43.0 24.2 0.00012 22.3 5.5 3.5 3 0 0 3 3 3 3 Cellulose binding domain DUF4352 PF11611.8 ELR22363.1 - 0.0087 16.3 0.5 0.63 10.3 0.1 2.9 3 0 0 3 3 3 1 Domain of unknown function (DUF4352) CARDB PF07705.11 ELR22363.1 - 0.23 11.7 10.9 6.4 7.1 0.2 4.0 3 1 0 4 4 4 0 CARDB CDT1 PF08839.11 ELR22364.1 - 1.1e-10 42.1 0.1 4.3e-10 40.2 0.1 2.0 2 1 0 2 2 2 1 DNA replication factor CDT1 like CDT1_C PF16679.5 ELR22364.1 - 5.7e-10 39.5 0.6 5.7e-10 39.5 0.6 1.9 2 0 0 2 2 2 1 DNA replication factor Cdt1 C-terminal domain Arm_3 PF16186.5 ELR22365.1 - 8.7e-23 79.6 5.0 1.1e-22 79.3 5.0 1.1 1 0 0 1 1 1 1 Atypical Arm repeat Mitofilin PF09731.9 ELR22366.1 - 2.7 6.7 12.4 3.4 6.4 12.4 1.1 1 0 0 1 1 1 0 Mitochondrial inner membrane protein CBM49 PF09478.10 ELR22368.1 - 1.7e-32 111.6 8.4 4.6e-17 62.1 0.7 3.1 3 0 0 3 3 3 3 Carbohydrate binding domain CBM49 CBM_2 PF00553.19 ELR22368.1 - 7e-11 42.3 23.8 0.00012 22.3 5.5 3.5 3 0 0 3 3 3 3 Cellulose binding domain DUF4352 PF11611.8 ELR22368.1 - 0.0076 16.5 0.4 0.62 10.4 0.1 2.9 3 0 0 3 3 3 1 Domain of unknown function (DUF4352) CARDB PF07705.11 ELR22368.1 - 0.25 11.6 10.6 6.2 7.1 0.2 4.0 3 1 1 4 4 4 0 CARDB GWT1 PF06423.12 ELR22369.1 - 1.2e-12 48.2 1.2 1.2e-12 48.2 1.2 3.6 3 2 1 4 4 4 2 GWT1 DUF4730 PF15873.5 ELR22370.1 - 0.033 14.5 0.2 0.033 14.5 0.2 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4730) YEATS PF03366.16 ELR22371.1 - 1.3e-31 108.4 0.2 2e-31 107.8 0.2 1.3 1 0 0 1 1 1 1 YEATS family APG6_N PF17675.1 ELR22371.1 - 0.088 13.3 2.9 0.13 12.8 2.9 1.1 1 0 0 1 1 1 0 Apg6 coiled-coil region TM2 PF05154.16 ELR22372.1 - 1.1e-12 48.1 10.3 1.8e-12 47.3 0.7 2.2 2 0 0 2 2 2 2 TM2 domain EF-hand_6 PF13405.6 ELR22374.1 - 1.5e-07 30.8 8.3 0.0099 15.7 0.2 4.6 4 0 0 4 4 4 2 EF-hand domain EF-hand_7 PF13499.6 ELR22374.1 - 2.4e-07 31.1 8.5 7.2e-06 26.4 2.2 3.5 3 1 1 4 4 4 2 EF-hand domain pair EF-hand_1 PF00036.32 ELR22374.1 - 0.00029 20.2 8.2 0.16 11.6 0.2 4.2 5 0 0 5 5 5 2 EF hand Plexin_cytopl PF08337.12 ELR22374.1 - 0.0019 16.9 0.0 0.0033 16.2 0.0 1.3 1 1 0 1 1 1 1 Plexin cytoplasmic RasGAP domain EF-hand_13 PF17958.1 ELR22374.1 - 0.0022 17.8 0.0 0.38 10.6 0.0 2.6 2 0 0 2 2 2 1 EF-hand domain EF-hand_8 PF13833.6 ELR22374.1 - 0.024 14.5 1.5 7 6.6 0.2 3.1 2 1 0 2 2 2 0 EF-hand domain pair EF-hand_5 PF13202.6 ELR22374.1 - 1.9 8.1 7.8 2.4 7.8 1.0 3.0 3 0 0 3 3 3 0 EF hand RCC1 PF00415.18 ELR22375.1 - 2.2e-70 233.1 10.2 8.9e-14 51.9 0.0 7.9 8 0 0 8 8 8 6 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 ELR22375.1 - 6.5e-38 127.8 16.6 4.7e-08 32.6 0.6 7.6 7 0 0 7 7 7 7 Regulator of chromosome condensation (RCC1) repeat SUKH-3 PF14433.6 ELR22375.1 - 0.17 12.4 1.2 29 5.1 0.0 3.7 4 0 0 4 4 4 0 SUKH-3 immunity protein BRO1 PF03097.18 ELR22379.1 - 1.3e-23 83.5 0.1 1.5e-23 83.2 0.1 1.2 1 0 0 1 1 1 1 BRO1-like domain DUF4167 PF13763.6 ELR22379.1 - 0.2 11.8 0.3 0.43 10.8 0.3 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4167) EGF_2 PF07974.13 ELR22380.1 - 1.1e-37 128.1 195.9 4.1e-06 27.1 6.4 13.5 13 0 0 13 13 13 12 EGF-like domain EGF PF00008.27 ELR22380.1 - 1.5e-21 76.3 155.0 9e-07 29.1 3.2 13.1 12 1 0 12 12 12 10 EGF-like domain hEGF PF12661.7 ELR22380.1 - 1.2e-14 54.3 140.8 0.0009 19.8 3.1 13.4 12 0 0 12 12 12 11 Human growth factor-like EGF RVT_2 PF07727.14 ELR22381.1 - 2.8e-41 141.8 0.0 3.2e-41 141.6 0.0 1.0 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF620 PF04788.12 ELR22381.1 - 0.012 15.1 0.0 0.016 14.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF620) rve PF00665.26 ELR22382.1 - 1.7e-06 28.2 0.0 2.8e-06 27.5 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 ELR22382.1 - 0.074 12.8 0.0 0.12 12.1 0.0 1.4 1 0 0 1 1 1 0 Integrase core domain SEA PF01390.20 ELR22382.1 - 0.16 12.1 0.0 0.18 11.9 0.0 1.3 1 0 0 1 1 1 0 SEA domain DUF3446 PF11928.8 ELR22384.1 - 0.41 11.0 16.3 0.07 13.4 6.0 2.8 1 1 1 2 2 2 0 Early growth response N-terminal domain TMEM154 PF15102.6 ELR22384.1 - 2.2 8.1 0.0 2.2 8.1 0.0 2.7 3 1 0 3 3 3 0 TMEM154 protein family LapA_dom PF06305.11 ELR22385.1 - 5.1e-05 23.0 0.1 0.00014 21.6 0.1 1.7 1 0 0 1 1 1 1 Lipopolysaccharide assembly protein A domain DUF4781 PF16013.5 ELR22385.1 - 0.045 12.6 0.3 0.1 11.4 0.3 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4781) DUF2681 PF10883.8 ELR22385.1 - 0.15 12.5 0.1 0.28 11.6 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2681) Phage_holin_2_4 PF16082.5 ELR22385.1 - 1.7 8.4 4.2 2.6 7.9 0.1 3.1 3 0 0 3 3 3 0 Bacteriophage holin family, superfamily II-like DUF373 PF04123.13 ELR22386.1 - 0.0073 15.8 3.5 0.0096 15.4 3.5 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF373) Tetraspanin PF00335.20 ELR22386.1 - 0.024 14.3 16.9 0.089 12.5 16.9 1.8 1 1 0 1 1 1 0 Tetraspanin family PIP49_N PF14875.6 ELR22386.1 - 0.066 13.1 0.9 0.066 13.1 0.9 1.4 1 1 0 1 1 1 0 N-term cysteine-rich ER, FAM69 DUF2644 PF10841.8 ELR22386.1 - 1.2 9.4 5.4 2 8.7 0.4 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2644) SCIMP PF15050.6 ELR22386.1 - 6.1 7.3 5.9 15 6.0 0.5 2.4 2 0 0 2 2 2 0 SCIMP protein RIO1 PF01163.22 ELR22387.1 - 5.4e-51 172.9 0.6 8.6e-51 172.2 0.2 1.4 2 0 0 2 2 2 1 RIO1 family Rio2_N PF09202.11 ELR22387.1 - 6.9e-34 115.9 0.9 1.7e-33 114.6 0.7 1.8 2 0 0 2 2 2 1 Rio2, N-terminal APH PF01636.23 ELR22387.1 - 4.7e-11 43.1 0.0 1.3e-05 25.3 0.0 2.9 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.14 ELR22387.1 - 7e-08 32.1 0.1 0.0057 16.0 0.0 2.6 2 0 0 2 2 2 2 Lipopolysaccharide kinase (Kdo/WaaP) family HTH_45 PF14947.6 ELR22387.1 - 0.0049 16.8 1.4 0.048 13.6 0.2 2.9 3 0 0 3 3 3 1 Winged helix-turn-helix PadR PF03551.14 ELR22387.1 - 0.039 13.9 2.0 5.9 6.9 0.2 3.2 2 1 1 3 3 3 0 Transcriptional regulator PadR-like family EcKinase PF02958.20 ELR22387.1 - 0.076 12.3 0.0 0.13 11.5 0.0 1.3 1 0 0 1 1 1 0 Ecdysteroid kinase FoP_duplication PF13865.6 ELR22388.1 - 7.6e-10 39.2 4.6 7.6e-10 39.2 4.6 3.8 2 1 1 3 3 3 1 C-terminal duplication domain of Friend of PRMT1 zf-B_box PF00643.24 ELR22388.1 - 0.0063 16.6 5.5 0.0063 16.6 5.5 1.8 2 0 0 2 2 2 1 B-box zinc finger Amelin PF05111.12 ELR22389.1 - 0.026 13.7 2.7 0.03 13.5 2.7 1.0 1 0 0 1 1 1 0 Ameloblastin precursor (Amelin) PEP-utilisers_N PF05524.13 ELR22389.1 - 0.045 13.9 0.0 0.051 13.7 0.0 1.2 1 0 0 1 1 1 0 PEP-utilising enzyme, N-terminal HATPase_c PF02518.26 ELR22390.1 - 4.1e-15 56.3 0.0 9.3e-15 55.1 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 ELR22390.1 - 7.4e-14 51.9 0.9 3.7e-09 36.7 0.0 2.9 2 1 0 2 2 2 2 Response regulator receiver domain HisKA PF00512.25 ELR22390.1 - 1.2e-12 47.7 0.0 2.8e-12 46.5 0.0 1.7 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain Drf_GBD PF06371.13 ELR22392.1 - 0.00044 19.9 0.1 0.00044 19.9 0.1 4.0 4 1 0 4 4 4 1 Diaphanous GTPase-binding Domain ETRAMP PF09716.10 ELR22392.1 - 1 9.5 5.4 5.8 7.0 0.7 3.3 3 0 0 3 3 3 0 Malarial early transcribed membrane protein (ETRAMP) Ribosomal_60s PF00428.19 ELR22392.1 - 3.2 8.4 20.3 3.7 8.2 6.1 4.0 3 0 0 3 3 3 0 60s Acidic ribosomal protein Dor1 PF04124.12 ELR22393.1 - 2.2e-91 306.0 0.4 3.1e-91 305.6 0.4 1.1 1 0 0 1 1 1 1 Dor1-like family Vps51 PF08700.11 ELR22393.1 - 8.8e-11 41.7 0.6 2.8e-10 40.1 0.6 1.8 1 0 0 1 1 1 1 Vps51/Vps67 COG2 PF06148.11 ELR22393.1 - 0.00037 20.6 0.4 0.001 19.2 0.4 1.7 1 0 0 1 1 1 1 COG (conserved oligomeric Golgi) complex component, COG2 Vps54_N PF10475.9 ELR22393.1 - 0.0011 18.3 5.8 0.0017 17.7 5.8 1.2 1 0 0 1 1 1 1 Vacuolar-sorting protein 54, of GARP complex Exo84_C PF16528.5 ELR22393.1 - 0.0022 17.8 0.1 0.59 9.9 0.0 3.1 3 1 0 3 3 3 1 Exocyst component 84 C-terminal Fib_alpha PF08702.10 ELR22393.1 - 0.026 14.7 1.0 0.07 13.3 1.0 1.7 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family Sec5 PF15469.6 ELR22393.1 - 0.039 13.8 0.6 0.12 12.1 0.4 1.9 1 1 0 1 1 1 0 Exocyst complex component Sec5 SKA2 PF16740.5 ELR22393.1 - 0.16 11.8 2.7 2.4 8.0 0.4 2.7 2 0 0 2 2 2 0 Spindle and kinetochore-associated protein 2 IKKbetaNEMObind PF12179.8 ELR22393.1 - 0.46 10.6 2.2 1.2 9.3 0.7 2.6 2 0 0 2 2 2 0 I-kappa-kinase-beta NEMO binding domain EF-hand_1 PF00036.32 ELR22394.1 - 7.6e-27 90.8 6.5 1.3e-06 27.5 0.2 4.2 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 ELR22394.1 - 2.8e-25 88.5 4.0 2.9e-12 46.9 0.4 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 ELR22394.1 - 2e-23 80.8 4.8 3.8e-05 23.0 0.1 4.4 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.6 ELR22394.1 - 2.3e-23 80.1 5.6 8.4e-06 25.3 0.1 4.3 4 0 0 4 4 4 4 EF-hand domain EF-hand_8 PF13833.6 ELR22394.1 - 5.1e-18 64.7 7.6 3.9e-08 33.0 0.1 3.8 2 2 2 4 4 4 4 EF-hand domain pair EF-hand_11 PF08976.11 ELR22394.1 - 1.9e-07 31.9 0.2 0.0088 16.9 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain SPARC_Ca_bdg PF10591.9 ELR22394.1 - 5.2e-07 30.0 4.5 0.00014 22.2 2.2 2.7 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region p25-alpha PF05517.12 ELR22394.1 - 8.5e-07 29.3 0.5 0.0045 17.2 0.0 2.2 2 0 0 2 2 2 2 p25-alpha PMBR PF09373.10 ELR22394.1 - 0.0041 17.2 0.2 14 6.0 0.0 3.3 3 0 0 3 3 3 0 Pseudomurein-binding repeat CDPS PF16715.5 ELR22394.1 - 0.03 14.0 0.6 0.043 13.4 0.6 1.3 1 0 0 1 1 1 0 Cyclodipeptide synthase BNR_4 PF15892.5 ELR22394.1 - 0.037 13.4 0.6 0.047 13.0 0.6 1.1 1 0 0 1 1 1 0 BNR repeat-containing family member EF-hand_10 PF14788.6 ELR22394.1 - 0.039 13.8 4.8 3.9 7.4 0.1 3.5 4 0 0 4 4 4 0 EF hand EF-hand_9 PF14658.6 ELR22394.1 - 0.07 13.5 0.2 0.36 11.2 0.0 2.1 2 0 0 2 2 2 0 EF-hand domain DCP1 PF06058.13 ELR22395.1 - 6e-36 122.9 0.1 8.4e-36 122.5 0.1 1.2 1 0 0 1 1 1 1 Dcp1-like decapping family mRNA_decap_C PF16741.5 ELR22395.1 - 0.012 14.9 0.1 0.027 13.8 0.1 1.6 1 0 0 1 1 1 0 mRNA-decapping enzyme C-terminus Macro PF01661.21 ELR22396.1 - 1.1e-31 109.3 0.0 1.9e-31 108.6 0.0 1.4 1 0 0 1 1 1 1 Macro domain UIM PF02809.20 ELR22396.1 - 0.12 12.3 4.6 0.29 11.1 4.6 1.7 1 0 0 1 1 1 0 Ubiquitin interaction motif RAP80_UIM PF18282.1 ELR22396.1 - 0.5 10.2 1.9 22 4.9 0.2 2.3 2 0 0 2 2 2 0 RAP80 N-terminal ubiquitin interaction motif Pkinase PF00069.25 ELR22397.1 - 1.3e-61 208.3 0.0 4.7e-44 150.7 0.1 2.1 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ELR22397.1 - 1.6e-27 96.4 0.5 2e-26 92.8 0.2 2.0 1 1 1 2 2 2 1 Protein tyrosine kinase Haspin_kinase PF12330.8 ELR22397.1 - 2.4e-05 23.4 0.0 5.4e-05 22.3 0.0 1.4 1 1 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 ELR22397.1 - 0.0012 18.2 0.6 0.022 14.1 0.2 3.0 2 1 0 2 2 2 1 Kinase-like Kdo PF06293.14 ELR22397.1 - 0.058 12.7 0.0 0.093 12.1 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family adh_short_C2 PF13561.6 ELR22398.1 - 3.1e-66 223.3 9.1 3.9e-66 223.0 9.1 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 ELR22398.1 - 2e-49 167.7 6.5 2.5e-49 167.4 6.5 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 ELR22398.1 - 1.6e-08 34.7 2.2 2.6e-08 34.0 2.2 1.3 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 ELR22398.1 - 0.03 13.8 0.5 0.05 13.1 0.5 1.4 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family Adenine_deam_C PF13382.6 ELR22398.1 - 1.2 8.4 6.7 0.65 9.3 4.0 1.8 2 0 0 2 2 2 0 Adenine deaminase C-terminal domain MFS_1 PF07690.16 ELR22399.1 - 1.3e-13 50.6 5.5 4.7e-13 48.8 5.5 1.7 1 1 0 1 1 1 1 Major Facilitator Superfamily BT1 PF03092.16 ELR22399.1 - 0.0001 20.7 0.5 0.00098 17.5 0.0 2.0 2 0 0 2 2 2 1 BT1 family Acatn PF13000.7 ELR22399.1 - 0.0011 17.5 0.0 0.0015 17.1 0.0 1.1 1 0 0 1 1 1 1 Acetyl-coenzyme A transporter 1 DUF3951 PF13131.6 ELR22399.1 - 0.12 12.6 1.2 2.6 8.3 0.9 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3951) Thioredoxin_4 PF13462.6 ELR22400.1 - 8.5e-20 71.6 0.3 2.3e-19 70.2 0.0 1.9 2 0 0 2 2 2 1 Thioredoxin DSBA PF01323.20 ELR22400.1 - 2e-07 31.0 2.7 1e-05 25.4 0.8 2.9 2 1 0 2 2 2 1 DSBA-like thioredoxin domain NAM-associated PF14303.6 ELR22401.1 - 0.039 14.7 1.5 0.039 14.7 1.5 3.2 4 0 0 4 4 4 0 No apical meristem-associated C-terminal domain RhoGAP PF00620.27 ELR22402.1 - 4.1e-24 85.1 0.0 1.4e-23 83.4 0.0 1.9 1 0 0 1 1 1 1 RhoGAP domain MCR_C PF04609.12 ELR22402.1 - 0.037 13.1 0.0 0.11 11.6 0.0 1.7 2 0 0 2 2 2 0 Methyl-coenzyme M reductase operon protein C DUF3918 PF13056.6 ELR22402.1 - 1.7 8.4 5.7 5.8 6.6 5.7 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF3918) LRR_6 PF13516.6 ELR22403.1 - 2.1e-06 27.3 2.8 0.11 12.5 0.3 5.4 5 0 0 5 5 5 2 Leucine Rich repeat Lipase_GDSL_2 PF13472.6 ELR22404.1 - 0.00032 21.1 1.0 0.013 15.9 1.0 2.6 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 ELR22404.1 - 0.021 14.8 0.0 2 8.4 0.0 2.3 1 1 1 2 2 2 0 GDSL-like Lipase/Acylhydrolase p450 PF00067.22 ELR22405.1 - 1.9e-59 201.6 1.0 5.4e-33 114.4 0.0 2.1 1 1 1 2 2 2 2 Cytochrome P450 PAP2 PF01569.21 ELR22405.1 - 0.00025 20.8 6.9 0.00025 20.8 6.9 2.2 3 0 0 3 3 3 1 PAP2 superfamily Actin PF00022.19 ELR22406.1 - 2e-54 184.8 0.0 3.2e-42 144.6 0.0 2.7 2 1 0 2 2 2 2 Actin Alpha-amylase PF00128.24 ELR22407.1 - 2.2e-79 267.5 0.3 1.6e-78 264.6 0.3 2.0 1 1 0 1 1 1 1 Alpha amylase, catalytic domain Malt_amylase_C PF16657.5 ELR22407.1 - 2.4e-07 30.8 0.0 0.00025 21.1 0.0 2.8 3 0 0 3 3 3 2 Maltogenic Amylase, C-terminal domain PhyH PF05721.13 ELR22408.1 - 2.7e-29 102.9 0.1 3.3e-29 102.7 0.1 1.1 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) 2OG-FeII_Oxy_3 PF13640.6 ELR22408.1 - 9.7e-05 23.2 0.0 0.00044 21.1 0.0 1.9 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_5 PF13759.6 ELR22408.1 - 0.0005 20.4 0.0 0.00094 19.6 0.0 1.5 1 0 0 1 1 1 1 Putative 2OG-Fe(II) oxygenase Cupin_2 PF07883.11 ELR22408.1 - 0.019 14.7 0.2 0.11 12.3 0.0 2.1 2 0 0 2 2 2 0 Cupin domain Glyco_hydro_18 PF00704.28 ELR22409.1 - 1.9e-19 70.5 0.0 2.9e-19 69.9 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 Lipase_GDSL_2 PF13472.6 ELR22409.1 - 0.0066 16.9 0.0 0.57 10.5 0.0 2.3 1 1 1 2 2 2 2 GDSL-like Lipase/Acylhydrolase family DUF4849 PF16141.5 ELR22409.1 - 0.18 11.1 0.0 0.24 10.6 0.0 1.2 1 0 0 1 1 1 0 Putative glycoside hydrolase Family 18, chitinase_18 RhoGEF PF00621.20 ELR22410.1 - 4.1e-29 102.1 0.0 8.6e-29 101.1 0.0 1.6 1 0 0 1 1 1 1 RhoGEF domain Ank_4 PF13637.6 ELR22410.1 - 7.7e-23 80.6 0.5 6e-05 23.5 0.0 5.8 5 1 1 6 6 6 4 Ankyrin repeats (many copies) Ank_2 PF12796.7 ELR22410.1 - 1.3e-22 80.2 6.0 8.8e-10 39.0 0.4 3.9 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank PF00023.30 ELR22410.1 - 4.5e-20 71.1 0.1 0.00011 22.5 0.1 5.7 5 0 0 5 5 5 5 Ankyrin repeat Ank_3 PF13606.6 ELR22410.1 - 4.2e-17 60.5 0.4 0.00041 20.6 0.0 5.5 5 0 0 5 5 5 3 Ankyrin repeat Ank_5 PF13857.6 ELR22410.1 - 4.1e-16 58.8 2.8 0.00045 20.5 0.0 4.7 4 0 0 4 4 4 3 Ankyrin repeats (many copies) AbLIM_anchor PF16182.5 ELR22410.1 - 0.011 15.5 14.9 0.023 14.6 14.9 1.5 1 0 0 1 1 1 0 Putative adherens-junction anchoring region of AbLIM DUF2151 PF10221.9 ELR22410.1 - 2.1 6.8 7.4 3.5 6.1 7.4 1.2 1 0 0 1 1 1 0 Cell cycle and development regulator Utp14 PF04615.13 ELR22410.1 - 3.7 6.0 25.3 5.6 5.4 25.3 1.2 1 0 0 1 1 1 0 Utp14 protein PAP1 PF08601.10 ELR22410.1 - 6.2 6.4 22.9 12 5.6 22.9 1.3 1 0 0 1 1 1 0 Transcription factor PAP1 Pkinase_Tyr PF07714.17 ELR22411.1 - 6.2e-123 409.1 0.0 4.3e-62 209.8 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 ELR22411.1 - 1.3e-106 355.9 0.0 4.1e-54 183.7 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain PBP_like_2 PF12849.7 ELR22411.1 - 5.6e-20 72.2 3.0 3.5e-09 36.7 0.0 2.3 2 0 0 2 2 2 2 PBP superfamily domain Guanylate_cyc PF00211.20 ELR22411.1 - 6.3e-17 61.8 0.0 1.2e-16 60.9 0.0 1.4 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain APH PF01636.23 ELR22411.1 - 3.8e-07 30.3 0.1 0.00022 21.2 0.0 2.6 2 0 0 2 2 2 2 Phosphotransferase enzyme family Kinase-like PF14531.6 ELR22411.1 - 0.00016 21.1 0.0 0.54 9.5 0.0 2.3 2 0 0 2 2 2 2 Kinase-like Haspin_kinase PF12330.8 ELR22411.1 - 0.00045 19.3 0.0 0.039 12.9 0.0 2.4 2 0 0 2 2 2 1 Haspin like kinase domain Kdo PF06293.14 ELR22411.1 - 0.016 14.6 0.1 2.9 7.2 0.0 2.4 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 ELR22411.1 - 0.025 14.2 0.3 7.5 6.1 0.0 2.4 2 0 0 2 2 2 0 RIO1 family EGF_2 PF07974.13 ELR22411.1 - 0.034 14.5 12.0 0.066 13.6 12.0 1.5 1 0 0 1 1 1 0 EGF-like domain Pkinase_fungal PF17667.1 ELR22411.1 - 0.037 12.8 0.0 5.1 5.8 0.0 2.2 2 0 0 2 2 2 0 Fungal protein kinase FTA2 PF13095.6 ELR22411.1 - 0.06 13.0 0.0 9.1 5.8 0.0 3.4 3 1 1 4 4 4 0 Kinetochore Sim4 complex subunit FTA2 EGF_Tenascin PF18720.1 ELR22411.1 - 0.075 13.1 4.2 0.18 11.9 4.2 1.6 1 0 0 1 1 1 0 Tenascin EGF domain Adeno_E3_CR2 PF02439.15 ELR22411.1 - 0.098 12.4 0.4 0.18 11.6 0.4 1.4 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 TRAP_alpha PF03896.16 ELR22411.1 - 0.13 11.4 2.5 0.13 11.4 0.0 2.1 2 0 0 2 2 2 0 Translocon-associated protein (TRAP), alpha subunit PfkB PF00294.24 ELR22412.1 - 1.7e-28 99.8 0.0 2.4e-14 53.4 0.1 2.1 2 0 0 2 2 2 2 pfkB family carbohydrate kinase SPX PF03105.19 ELR22412.1 - 0.079 12.9 8.5 0.12 12.2 8.5 1.3 1 0 0 1 1 1 0 SPX domain Apt1 PF10351.9 ELR22412.1 - 0.28 10.0 4.2 0.35 9.7 4.2 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain MORN_2 PF07661.13 ELR22413.1 - 6.9e-14 50.3 0.1 0.00016 21.5 0.0 4.3 4 0 0 4 4 4 4 MORN repeat variant Chitin_bind_4 PF00379.23 ELR22413.1 - 0.0051 17.3 1.7 0.044 14.3 0.2 3.0 3 1 1 4 4 4 1 Insect cuticle protein Glyco_trans_A_1 PF09318.10 ELR22413.1 - 0.042 13.5 0.0 0.29 10.8 0.0 2.0 1 1 1 2 2 2 0 Glycosyl transferase 1 domain A Thiol_cytolys_C PF17440.2 ELR22413.1 - 0.8 9.9 4.6 0.19 11.9 1.3 1.7 2 0 0 2 2 2 0 Thiol-activated cytolysin beta sandwich domain VWA_3 PF13768.6 ELR22414.1 - 4.1e-30 104.8 0.0 3.2e-26 92.1 0.0 3.4 2 1 1 3 3 3 2 von Willebrand factor type A domain VIT PF08487.10 ELR22414.1 - 2.1e-27 95.5 0.0 2.1e-27 95.5 0.0 2.3 2 0 0 2 2 1 1 Vault protein inter-alpha-trypsin domain Synaptobrevin PF00957.21 ELR22414.1 - 4.1e-16 58.5 0.3 8e-16 57.6 0.3 1.5 1 0 0 1 1 1 1 Synaptobrevin VWA PF00092.28 ELR22414.1 - 8.7e-16 58.7 0.0 7.4e-15 55.6 0.0 2.3 1 1 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.6 ELR22414.1 - 8.2e-14 52.2 0.0 2.9e-13 50.4 0.0 2.0 1 0 0 1 1 1 1 von Willebrand factor type A domain UBA_4 PF14555.6 ELR22414.1 - 4.9e-11 42.3 0.5 1.1e-10 41.1 0.5 1.7 1 0 0 1 1 1 1 UBA-like domain VIT_2 PF13757.6 ELR22414.1 - 6.1e-10 38.8 0.1 1.7e-09 37.4 0.1 1.7 1 0 0 1 1 1 1 Vault protein inter-alpha-trypsin domain YL1 PF05764.13 ELR22414.1 - 0.00025 21.3 7.1 0.00043 20.5 7.1 1.3 1 0 0 1 1 1 1 YL1 nuclear protein Cwf_Cwc_15 PF04889.12 ELR22414.1 - 0.00039 20.2 8.6 0.00072 19.4 8.6 1.4 1 0 0 1 1 1 1 Cwf15/Cwc15 cell cycle control protein VWA_CoxE PF05762.14 ELR22414.1 - 0.0014 18.1 0.1 0.0028 17.1 0.1 1.4 1 0 0 1 1 1 1 VWA domain containing CoxE-like protein CDC45 PF02724.14 ELR22414.1 - 0.0085 14.4 1.4 0.013 13.9 1.4 1.2 1 0 0 1 1 1 1 CDC45-like protein TAP_C PF03943.13 ELR22414.1 - 0.022 14.4 0.0 0.043 13.5 0.0 1.5 1 0 0 1 1 1 0 TAP C-terminal domain Ferlin_C PF16165.5 ELR22414.1 - 0.59 10.1 4.2 1.1 9.1 4.2 1.4 1 0 0 1 1 1 0 Ferlin C-terminus Dsh_C PF12316.8 ELR22414.1 - 2.5 8.5 11.9 7.9 6.8 11.9 1.9 1 1 0 1 1 1 0 Segment polarity protein dishevelled (Dsh) C terminal RR_TM4-6 PF06459.12 ELR22414.1 - 8.3 6.1 8.0 15 5.3 8.0 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 HIG_1_N PF04588.13 ELR22416.1 - 1.5e-13 50.7 1.9 2e-13 50.4 1.9 1.2 1 0 0 1 1 1 1 Hypoxia induced protein conserved region Thioredoxin_4 PF13462.6 ELR22417.1 - 5.1e-19 69.0 0.0 6e-19 68.8 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin DSBA PF01323.20 ELR22417.1 - 4.9e-10 39.5 0.8 6.6e-08 32.6 0.8 2.1 1 1 0 1 1 1 1 DSBA-like thioredoxin domain A2L_zn_ribbon PF08792.10 ELR22417.1 - 0.033 13.9 0.2 0.06 13.1 0.2 1.4 1 0 0 1 1 1 0 A2L zinc ribbon domain Thioredoxin PF00085.20 ELR22417.1 - 0.096 12.7 0.0 1.6 8.8 0.0 2.1 2 0 0 2 2 2 0 Thioredoxin zf-Mss51 PF13824.6 ELR22417.1 - 0.1 12.7 0.1 0.19 11.8 0.1 1.4 1 0 0 1 1 1 0 Zinc-finger of mitochondrial splicing suppressor 51 SapB_2 PF03489.17 ELR22418.1 - 5.5e-06 26.4 0.2 1.3e-05 25.2 0.2 1.7 1 0 0 1 1 1 1 Saposin-like type B, region 2 DUF4604 PF15377.6 ELR22419.1 - 3.2e-07 30.9 22.5 4.5e-07 30.5 22.5 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4604) Hamartin PF04388.12 ELR22419.1 - 0.69 8.5 8.7 0.8 8.3 8.7 1.0 1 0 0 1 1 1 0 Hamartin protein GREB1 PF15782.5 ELR22419.1 - 5.3 4.0 13.3 6.6 3.7 13.3 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer DUF572 PF04502.13 ELR22419.1 - 7.1 6.2 21.3 9.3 5.8 21.3 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) Kinesin PF00225.23 ELR22420.1 - 2.3e-68 230.6 6.9 1.7e-36 125.8 0.0 3.3 2 1 1 3 3 3 2 Kinesin motor domain Microtub_bd PF16796.5 ELR22420.1 - 4.3e-27 94.9 0.0 1.9e-26 92.8 0.0 2.2 1 0 0 1 1 1 1 Microtubule binding HALZ PF02183.18 ELR22420.1 - 1.6 9.0 17.7 2.4 8.5 0.0 5.5 5 0 0 5 5 5 0 Homeobox associated leucine zipper PrgI PF12666.7 ELR22421.1 - 0.025 15.3 0.3 0.047 14.4 0.3 1.3 1 0 0 1 1 1 0 PrgI family protein Iso_dh PF00180.20 ELR22422.1 - 3.3e-86 289.6 0.0 3.2e-83 279.8 0.0 2.1 1 1 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase MSP1b PF03429.13 ELR22422.1 - 0.077 11.1 0.1 0.11 10.6 0.1 1.2 1 0 0 1 1 1 0 Major surface protein 1B Abhydrolase_1 PF00561.20 ELR22423.1 - 7.4e-11 42.2 0.0 1.1e-10 41.6 0.0 1.3 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 ELR22423.1 - 5.3e-08 33.7 0.0 5.9e-08 33.6 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 ELR22423.1 - 5.8e-08 32.3 0.0 7.3e-08 32.0 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Esterase PF00756.20 ELR22423.1 - 0.00024 20.8 0.0 0.00038 20.2 0.0 1.2 1 0 0 1 1 1 1 Putative esterase BAAT_C PF08840.11 ELR22423.1 - 0.0047 16.9 0.0 0.0062 16.5 0.0 1.2 1 0 0 1 1 1 1 BAAT / Acyl-CoA thioester hydrolase C terminal PGAP1 PF07819.13 ELR22423.1 - 0.005 16.6 0.0 0.0061 16.3 0.0 1.3 1 0 0 1 1 1 1 PGAP1-like protein Lipase_3 PF01764.25 ELR22423.1 - 0.0067 16.3 0.0 0.013 15.4 0.0 1.4 1 0 0 1 1 1 1 Lipase (class 3) Abhydrolase_8 PF06259.12 ELR22423.1 - 0.041 13.5 0.1 0.077 12.6 0.1 1.4 1 1 0 1 1 1 0 Alpha/beta hydrolase Thioesterase PF00975.20 ELR22423.1 - 0.041 14.0 0.0 0.066 13.3 0.0 1.3 1 0 0 1 1 1 0 Thioesterase domain LIDHydrolase PF10230.9 ELR22423.1 - 0.1 12.1 0.0 0.14 11.6 0.0 1.3 1 0 0 1 1 1 0 Lipid-droplet associated hydrolase Ser_hydrolase PF06821.13 ELR22423.1 - 0.14 12.0 0.0 0.22 11.4 0.0 1.3 1 0 0 1 1 1 0 Serine hydrolase Abhydrolase_5 PF12695.7 ELR22423.1 - 0.19 11.5 0.0 0.24 11.2 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase family LSM PF01423.22 ELR22424.1 - 1.7e-19 69.2 0.5 2.4e-19 68.8 0.5 1.2 1 0 0 1 1 1 1 LSM domain DUF150_C PF17384.2 ELR22424.1 - 0.1 12.7 0.8 0.26 11.5 0.7 1.7 1 1 1 2 2 2 0 RimP C-terminal SH3 domain Pkinase PF00069.25 ELR22425.1 - 6.5e-68 228.9 0.0 7.8e-68 228.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR22425.1 - 9.1e-37 126.7 0.0 1.1e-36 126.4 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ELR22425.1 - 4.5e-12 45.9 0.0 6.1e-12 45.4 0.0 1.2 1 0 0 1 1 1 1 Kinase-like YrbL-PhoP_reg PF10707.9 ELR22425.1 - 5.5e-05 22.8 0.1 0.00044 19.8 0.1 2.3 2 1 0 2 2 2 1 PhoP regulatory network protein YrbL Kdo PF06293.14 ELR22425.1 - 6.8e-05 22.3 0.0 0.00012 21.5 0.0 1.4 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 ELR22425.1 - 7.3e-05 22.4 0.2 0.054 13.1 0.0 2.2 1 1 1 2 2 2 2 RIO1 family APH PF01636.23 ELR22425.1 - 0.0002 21.4 0.0 0.00033 20.6 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 ELR22425.1 - 0.0019 17.3 0.0 0.0024 16.9 0.0 1.2 1 0 0 1 1 1 1 Haspin like kinase domain ABC1 PF03109.16 ELR22425.1 - 0.0086 16.2 0.0 0.018 15.2 0.0 1.6 1 0 0 1 1 1 1 ABC1 family Pkinase_fungal PF17667.1 ELR22425.1 - 0.02 13.7 0.0 0.048 12.4 0.0 1.6 1 1 0 1 1 1 0 Fungal protein kinase F-box-like PF12937.7 ELR22426.1 - 3.4e-10 39.6 1.2 8.5e-10 38.4 1.2 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ELR22426.1 - 0.0044 16.9 0.1 0.0096 15.8 0.1 1.6 1 0 0 1 1 1 1 F-box domain RNA_pol_3_Rpc31 PF11705.8 ELR22426.1 - 0.42 10.8 11.1 0.19 12.0 1.5 2.3 2 0 0 2 2 2 0 DNA-directed RNA polymerase III subunit Rpc31 UPF0183 PF03676.14 ELR22427.1 - 2.7e-92 310.1 0.0 3.5e-92 309.7 0.0 1.1 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0183) CPBP PF02517.16 ELR22428.1 - 8.7e-18 64.5 6.7 8.7e-18 64.5 6.7 2.7 4 1 0 4 4 4 1 CPBP intramembrane metalloprotease Abhydrolase_9_N PF15420.6 ELR22428.1 - 0.63 10.0 3.9 0.28 11.2 1.5 1.6 2 0 0 2 2 2 0 Alpha/beta-hydrolase family N-terminus CoA_transf_3 PF02515.17 ELR22429.1 - 6.3e-69 232.9 0.0 9.7e-41 140.1 0.0 2.2 1 1 1 2 2 2 2 CoA-transferase family III NT-C2 PF10358.9 ELR22430.1 - 0.018 14.8 0.2 0.43 10.3 0.1 2.5 2 1 1 3 3 3 0 N-terminal C2 in EEIG1 and EHBP1 proteins DASH_Spc19 PF08287.11 ELR22430.1 - 6.1 6.7 9.9 50 3.8 9.9 2.0 1 1 0 1 1 1 0 Spc19 F-box-like PF12937.7 ELR22431.1 - 2.4e-09 36.9 1.6 3.6e-07 30.0 2.1 2.9 3 1 0 3 3 3 1 F-box-like F-box PF00646.33 ELR22431.1 - 0.0034 17.2 0.3 0.012 15.5 0.2 2.1 1 1 1 2 2 2 1 F-box domain Elongin_A PF06881.11 ELR22431.1 - 0.011 16.3 0.6 0.011 16.3 0.6 1.7 2 0 0 2 2 2 0 RNA polymerase II transcription factor SIII (Elongin) subunit A Pkinase_Tyr PF07714.17 ELR22432.1 - 5.7e-130 432.2 0.0 2.6e-64 217.0 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 ELR22432.1 - 2e-109 365.0 0.0 9e-54 182.6 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain PBP_like_2 PF12849.7 ELR22432.1 - 7.8e-27 94.7 2.5 3.7e-21 76.0 0.8 2.4 2 0 0 2 2 2 2 PBP superfamily domain Guanylate_cyc PF00211.20 ELR22432.1 - 3.2e-08 33.4 0.0 6.6e-08 32.4 0.0 1.4 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain APH PF01636.23 ELR22432.1 - 9.5e-08 32.3 0.0 0.00011 22.2 0.0 3.0 2 0 0 2 2 2 2 Phosphotransferase enzyme family Haspin_kinase PF12330.8 ELR22432.1 - 3.8e-05 22.8 0.0 0.023 13.6 0.0 3.2 3 0 0 3 3 3 1 Haspin like kinase domain RIO1 PF01163.22 ELR22432.1 - 9.3e-05 22.1 0.4 0.093 12.3 0.1 2.4 2 0 0 2 2 2 2 RIO1 family EGF_2 PF07974.13 ELR22432.1 - 0.00045 20.5 8.1 0.00094 19.5 8.1 1.6 1 0 0 1 1 1 1 EGF-like domain Kinase-like PF14531.6 ELR22432.1 - 0.00097 18.5 0.0 0.32 10.3 0.0 3.1 3 0 0 3 3 3 1 Kinase-like FTA2 PF13095.6 ELR22432.1 - 0.0011 18.7 0.0 0.09 12.4 0.0 2.7 2 1 0 2 2 2 1 Kinetochore Sim4 complex subunit FTA2 DUF347 PF03988.12 ELR22432.1 - 0.0013 18.9 2.2 0.004 17.3 2.2 1.8 1 0 0 1 1 1 1 Repeat of Unknown Function (DUF347) EGF PF00008.27 ELR22432.1 - 0.0062 16.8 4.7 0.012 15.9 4.7 1.5 1 0 0 1 1 1 1 EGF-like domain EGF_Tenascin PF18720.1 ELR22432.1 - 0.01 15.9 6.1 0.028 14.5 6.1 1.7 1 0 0 1 1 1 0 Tenascin EGF domain Kdo PF06293.14 ELR22432.1 - 0.035 13.4 0.1 0.89 8.9 0.0 2.3 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family hEGF PF12661.7 ELR22432.1 - 0.093 13.4 2.6 0.22 12.2 2.6 1.7 1 0 0 1 1 1 0 Human growth factor-like EGF TMEM154 PF15102.6 ELR22432.1 - 0.27 11.1 0.0 0.27 11.1 0.0 2.9 3 0 0 3 3 3 0 TMEM154 protein family Laminin_EGF PF00053.24 ELR22432.1 - 1.3 9.2 5.7 2.8 8.2 5.7 1.5 1 0 0 1 1 1 0 Laminin EGF domain SKG6 PF08693.10 ELR22432.1 - 1.9 7.9 9.5 0.11 11.9 3.0 2.4 2 0 0 2 2 2 0 Transmembrane alpha-helix domain DUF913 PF06025.12 ELR22433.1 - 0.74 8.7 2.0 1.1 8.2 2.0 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) DUF3530 PF12048.8 ELR22433.1 - 3.3 7.0 8.6 36 3.6 8.6 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF3530) DUF2781 PF10914.8 ELR22434.1 - 2.9e-39 134.8 17.3 3.3e-39 134.7 17.3 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2781) CcmH PF03918.14 ELR22434.1 - 0.21 10.9 0.3 0.37 10.1 0.3 1.4 1 0 0 1 1 1 0 Cytochrome C biogenesis protein MPM1 PF17234.2 ELR22435.1 - 0.97 9.7 14.3 1.3 9.2 14.3 1.3 1 0 0 1 1 1 0 Mitochondrial peculiar membrane protein 1 MCM_bind PF09739.9 ELR22435.1 - 2.5 6.4 14.6 3.5 5.9 14.6 1.4 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor CDC45 PF02724.14 ELR22435.1 - 3.2 5.9 19.1 3.8 5.7 19.1 1.1 1 0 0 1 1 1 0 CDC45-like protein Asp-B-Hydro_N PF05279.11 ELR22435.1 - 3.3 7.7 21.0 3.7 7.5 21.0 1.1 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region Red1 PF07964.11 ELR22435.1 - 8.4 4.5 17.1 9.8 4.3 17.1 1.0 1 0 0 1 1 1 0 Rec10 / Red1 Rtf2 PF04641.12 ELR22435.1 - 9.7 5.5 20.4 13 5.0 20.4 1.4 1 0 0 1 1 1 0 Rtf2 RING-finger DAGAT PF03982.13 ELR22437.1 - 2.3e-36 125.3 0.5 1.5e-27 96.3 0.0 2.1 1 1 1 2 2 2 2 Diacylglycerol acyltransferase LAGLIDADG_3 PF14528.6 ELR22437.1 - 0.0087 16.4 0.2 2 8.8 0.0 2.5 2 0 0 2 2 2 2 LAGLIDADG-like domain RlaP PF10127.9 ELR22438.1 - 2.3e-05 24.1 0.2 5.5e-05 22.9 0.1 1.7 2 0 0 2 2 2 1 RNA repair pathway DNA polymerase beta family NTP_transf_2 PF01909.23 ELR22438.1 - 0.00027 21.2 0.0 0.0007 19.8 0.0 1.8 1 0 0 1 1 1 1 Nucleotidyltransferase domain Polbeta PF18765.1 ELR22438.1 - 0.026 14.6 0.1 0.057 13.5 0.1 1.6 1 0 0 1 1 1 0 Polymerase beta, Nucleotidyltransferase PhoLip_ATPase_N PF16209.5 ELR22438.1 - 0.12 12.1 0.0 0.25 11.0 0.0 1.5 1 0 0 1 1 1 0 Phospholipid-translocating ATPase N-terminal FPN1 PF06963.12 ELR22439.1 - 6.3e-76 255.7 22.1 6.5e-73 245.8 22.1 2.7 1 1 0 1 1 1 1 Ferroportin1 (FPN1) Holin_9 PF16936.5 ELR22439.1 - 1.9 8.7 0.0 1.9 8.7 0.0 3.8 4 0 0 4 4 4 0 Putative holin CoA_binding_3 PF13727.6 ELR22439.1 - 8.1 6.4 7.2 8.4 6.4 0.2 3.5 3 1 1 4 4 4 0 CoA-binding domain Phytochelatin PF05023.14 ELR22440.1 - 3.8e-67 225.6 0.0 7.5e-67 224.7 0.0 1.4 1 0 0 1 1 1 1 Phytochelatin synthase SR-25 PF10500.9 ELR22440.1 - 0.011 15.3 3.0 0.011 15.3 3.0 1.9 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein LUC7 PF03194.15 ELR22440.1 - 0.036 13.7 0.5 0.07 12.8 0.5 1.4 1 0 0 1 1 1 0 LUC7 N_terminus DUF1180 PF06679.12 ELR22440.1 - 0.96 9.8 4.5 0.71 10.3 1.7 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1180) DUF563 PF04577.14 ELR22441.1 - 1.6e-31 110.1 1.3 8.8e-31 107.7 0.1 2.4 2 1 0 2 2 2 1 Protein of unknown function (DUF563) Ephrin_rec_like PF07699.13 ELR22441.1 - 4.2e-09 36.0 18.9 2.8e-06 27.0 8.4 2.6 1 1 1 2 2 2 2 Putative ephrin-receptor like NCD3G PF07562.14 ELR22441.1 - 0.00045 20.1 9.0 0.043 13.8 0.7 2.6 2 0 0 2 2 2 2 Nine Cysteines Domain of family 3 GPCR TNFR_c6 PF00020.18 ELR22441.1 - 0.0015 18.9 8.7 0.076 13.4 0.5 3.1 2 1 2 4 4 4 3 TNFR/NGFR cysteine-rich region VSP PF03302.13 ELR22441.1 - 0.16 10.8 5.3 0.24 10.2 5.3 1.1 1 0 0 1 1 1 0 Giardia variant-specific surface protein Mito_carr PF00153.27 ELR22442.1 - 5.1e-48 161.0 1.5 5.5e-17 61.5 0.0 3.2 2 1 1 3 3 3 3 Mitochondrial carrier protein Tim17 PF02466.19 ELR22442.1 - 0.0011 19.3 0.2 0.014 15.8 0.2 2.4 2 0 0 2 2 2 1 Tim17/Tim22/Tim23/Pmp24 family Aminotran_1_2 PF00155.21 ELR22444.1 - 2.1e-05 23.9 0.0 2.5e-05 23.6 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Mito_carr PF00153.27 ELR22445.1 - 8e-10 38.5 0.0 1.2e-09 38.0 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial carrier protein Chlorophyllase PF07224.11 ELR22445.1 - 0.16 10.9 0.0 0.2 10.7 0.0 1.1 1 0 0 1 1 1 0 Chlorophyllase Aminotran_1_2 PF00155.21 ELR22446.1 - 1.7e-26 93.2 0.0 2.1e-26 92.9 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_MocR PF12897.7 ELR22446.1 - 3.4e-08 32.7 0.0 4.6e-08 32.3 0.0 1.1 1 0 0 1 1 1 1 Alanine-glyoxylate amino-transferase Pkinase PF00069.25 ELR22447.1 - 6.6e-59 199.4 0.0 8.6e-33 113.8 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ELR22447.1 - 4.5e-25 88.4 0.0 1.3e-17 64.0 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase SpoIIIAH PF12685.7 ELR22447.1 - 0.019 14.8 0.8 3.4 7.4 0.0 2.3 2 0 0 2 2 2 0 SpoIIIAH-like protein Pkinase_fungal PF17667.1 ELR22447.1 - 0.024 13.4 0.0 0.05 12.4 0.0 1.5 1 0 0 1 1 1 0 Fungal protein kinase RNA_pol_Rpc4 PF05132.14 ELR22447.1 - 0.069 13.6 5.7 1.8 9.0 2.7 2.2 2 0 0 2 2 2 0 RNA polymerase III RPC4 Astro_capsid_N PF03115.14 ELR22447.1 - 0.094 11.4 0.1 0.16 10.6 0.1 1.3 1 0 0 1 1 1 0 Astrovirus capsid protein precursor Myc_N PF01056.18 ELR22447.1 - 0.29 11.0 7.9 3.4 7.5 1.4 2.1 2 0 0 2 2 2 0 Myc amino-terminal region Presenilin PF01080.17 ELR22447.1 - 0.88 8.3 2.6 4.3 6.0 0.3 2.0 2 0 0 2 2 2 0 Presenilin Mucin PF01456.17 ELR22447.1 - 1.2 9.1 8.5 11 5.9 0.0 2.2 2 0 0 2 2 2 0 Mucin-like glycoprotein Nop14 PF04147.12 ELR22447.1 - 1.8 6.7 14.8 0.12 10.6 1.4 2.2 2 0 0 2 2 2 0 Nop14-like family Zip PF02535.22 ELR22447.1 - 6.2 5.9 8.1 1 8.5 0.1 2.3 2 1 0 2 2 2 0 ZIP Zinc transporter TsaE PF02367.17 ELR22448.1 - 6.5e-12 45.5 0.0 8.5e-12 45.2 0.0 1.1 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_16 PF13191.6 ELR22448.1 - 0.0019 18.6 0.0 0.0025 18.2 0.0 1.2 1 0 0 1 1 1 1 AAA ATPase domain AAA_7 PF12775.7 ELR22448.1 - 0.012 15.1 0.0 0.014 14.9 0.0 1.2 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_22 PF13401.6 ELR22448.1 - 0.024 14.9 0.1 0.042 14.1 0.1 1.5 1 1 0 1 1 1 0 AAA domain VirE PF05272.11 ELR22448.1 - 0.046 13.4 0.0 0.052 13.3 0.0 1.1 1 0 0 1 1 1 0 Virulence-associated protein E AAA_19 PF13245.6 ELR22448.1 - 0.093 13.1 0.0 0.13 12.6 0.0 1.2 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.6 ELR22448.1 - 0.096 12.4 0.1 0.15 11.8 0.1 1.4 1 1 0 1 1 1 0 AAA domain ATPase PF06745.13 ELR22448.1 - 0.23 10.8 0.0 0.24 10.7 0.0 1.2 1 0 0 1 1 1 0 KaiC Cofilin_ADF PF00241.20 ELR22449.1 - 2.1e-10 40.4 0.0 3.8e-10 39.6 0.0 1.4 1 1 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein RhoGAP PF00620.27 ELR22450.1 - 1.9e-23 83.0 0.0 2.8e-23 82.4 0.0 1.2 1 0 0 1 1 1 1 RhoGAP domain Vps62 PF06101.11 ELR22450.1 - 1.3e-19 69.9 0.0 2.2e-19 69.2 0.0 1.3 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 62 Asp PF00026.23 ELR22451.1 - 1.8e-17 63.8 0.0 4.2e-17 62.5 0.0 1.5 1 1 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_C PF14541.6 ELR22451.1 - 5e-10 39.4 0.0 4.4e-09 36.3 0.0 2.1 1 1 0 1 1 1 1 Xylanase inhibitor C-terminal TAXi_N PF14543.6 ELR22451.1 - 0.00035 20.9 0.1 0.0008 19.7 0.1 1.5 1 0 0 1 1 1 1 Xylanase inhibitor N-terminal HAMP PF00672.25 ELR22452.1 - 2.1e-53 178.5 26.1 9.9e-08 32.2 0.1 10.7 10 0 0 10 10 9 7 HAMP domain HATPase_c PF02518.26 ELR22452.1 - 1.9e-30 105.7 0.1 5.3e-30 104.2 0.1 1.8 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 ELR22452.1 - 6.3e-30 103.6 0.0 7e-26 90.6 0.0 3.1 2 0 0 2 2 2 2 Response regulator receiver domain HisKA PF00512.25 ELR22452.1 - 2.3e-20 72.4 0.1 1.7e-19 69.6 0.1 2.8 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain DUF948 PF06103.11 ELR22452.1 - 3.3e-11 43.3 59.9 0.14 12.4 1.9 10.9 1 1 5 7 7 7 7 Bacterial protein of unknown function (DUF948) APG17 PF04108.12 ELR22452.1 - 9.2e-11 41.5 0.0 0.37 9.8 0.0 5.2 1 1 3 5 5 5 3 Autophagy protein Apg17 SpoIIID PF12116.8 ELR22452.1 - 3.4e-08 33.4 1.8 23 5.2 0.0 7.6 7 0 0 7 7 7 0 Stage III sporulation protein D WXG100 PF06013.12 ELR22452.1 - 2.2e-07 31.0 27.6 0.89 9.8 0.4 8.1 8 0 0 8 8 8 4 Proteins of 100 residues with WXG PseudoU_synth_1 PF01416.20 ELR22452.1 - 2.8e-07 31.0 7.9 2.9 8.4 0.0 7.3 4 2 2 7 7 7 1 tRNA pseudouridine synthase HTH_6 PF01418.17 ELR22452.1 - 2.5e-05 24.1 0.0 30 4.7 0.0 5.9 6 0 0 6 6 6 0 Helix-turn-helix domain, rpiR family Zw10 PF06248.13 ELR22452.1 - 7.9e-05 21.4 9.0 0.59 8.6 0.6 5.2 2 1 5 7 7 7 2 Centromere/kinetochore Zw10 DUF3829 PF12889.7 ELR22452.1 - 9.8e-05 22.0 13.7 6 6.3 0.0 6.7 4 3 3 9 9 9 1 Protein of unknown function (DUF3829) GatB_Yqey PF02637.18 ELR22452.1 - 0.00019 21.3 13.6 1.1 9.1 0.1 6.3 6 0 0 6 6 6 2 GatB domain GLE1 PF07817.13 ELR22452.1 - 0.0002 20.7 8.6 5.3 6.2 0.0 5.8 2 2 4 6 6 6 1 GLE1-like protein ApoLp-III PF07464.11 ELR22452.1 - 0.0003 20.9 28.5 2.1 8.4 1.1 6.9 1 1 5 6 6 6 3 Apolipophorin-III precursor (apoLp-III) DUF1843 PF08898.10 ELR22452.1 - 0.0003 21.2 16.4 10 6.7 0.1 7.3 7 0 0 7 7 7 0 Domain of unknown function (DUF1843) Syntaxin_2 PF14523.6 ELR22452.1 - 0.00039 20.7 4.9 15 6.0 0.0 6.6 2 2 7 9 9 9 0 Syntaxin-like protein DUF1759 PF03564.15 ELR22452.1 - 0.0019 18.2 5.5 35 4.3 0.0 6.2 7 0 0 7 7 6 0 Protein of unknown function (DUF1759) Zwint PF15556.6 ELR22452.1 - 0.024 14.2 5.1 9.5 5.6 0.0 4.6 5 0 0 5 5 5 0 ZW10 interactor Phage_lysis PF03245.13 ELR22452.1 - 0.035 14.2 18.8 13 5.9 0.2 6.2 6 0 0 6 6 6 0 Bacteriophage Rz lysis protein DUF4172 PF13776.6 ELR22452.1 - 0.059 13.7 0.1 1.7 9.1 0.0 3.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4172) NAAA-beta PF15508.6 ELR22452.1 - 0.065 13.5 0.8 47 4.4 0.0 5.2 5 0 0 5 5 4 0 beta subunit of N-acylethanolamine-hydrolyzing acid amidase Big_6 PF17936.1 ELR22452.1 - 0.076 13.3 30.5 1.8 8.9 0.4 7.0 7 0 0 7 7 7 0 Bacterial Ig domain tRNA_bind_2 PF13725.6 ELR22452.1 - 0.35 10.5 3.1 22 4.6 0.0 3.8 3 1 1 4 4 4 0 Possible tRNA binding domain NYD-SP28 PF14772.6 ELR22452.1 - 1.8 8.7 7.3 1.4e+02 2.6 0.0 5.5 6 0 0 6 6 6 0 Sperm tail Mer2 PF09074.10 ELR22452.1 - 6.9 6.4 19.9 9.8 5.9 0.0 5.6 2 2 2 5 5 5 0 Mer2 Presenilin PF01080.17 ELR22453.1 - 2.2 7.0 3.1 2 7.1 3.1 1.0 1 0 0 1 1 1 0 Presenilin FAM176 PF14851.6 ELR22453.1 - 2.2 7.9 5.1 2.5 7.7 5.1 1.1 1 0 0 1 1 1 0 FAM176 family Zip PF02535.22 ELR22453.1 - 3.3 6.9 3.3 3.2 6.9 3.3 1.0 1 0 0 1 1 1 0 ZIP Zinc transporter DUF4127 PF13552.6 ELR22454.1 - 1e-107 360.8 0.1 1.3e-107 360.5 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF4127) DUF1348 PF07080.11 ELR22454.1 - 0.0049 16.8 0.2 0.0049 16.8 0.2 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF1348) Transket_pyr PF02779.24 ELR22454.1 - 0.1 12.3 0.0 0.18 11.5 0.0 1.3 1 0 0 1 1 1 0 Transketolase, pyrimidine binding domain BRCT_2 PF16589.5 ELR22454.1 - 0.14 12.6 0.0 0.41 11.1 0.0 1.7 2 0 0 2 2 2 0 BRCT domain, a BRCA1 C-terminus domain Phosphoesterase PF04185.14 ELR22455.1 - 5.5e-33 114.6 0.3 1e-31 110.4 0.2 2.2 1 1 0 1 1 1 1 Phosphoesterase family CarboxypepD_reg PF13620.6 ELR22456.1 - 8.4e-07 29.2 4.9 0.035 14.4 0.1 4.5 4 0 0 4 4 4 3 Carboxypeptidase regulatory-like domain SdrD_B PF17210.3 ELR22456.1 - 0.0036 17.5 0.9 0.0036 17.5 0.9 4.3 3 1 0 3 3 3 1 SdrD B-like domain Big_1 PF02369.16 ELR22456.1 - 0.039 14.0 3.5 0.055 13.5 0.2 2.9 3 0 0 3 3 3 0 Bacterial Ig-like domain (group 1) CarbopepD_reg_2 PF13715.6 ELR22456.1 - 0.11 12.5 0.5 6.9 6.8 0.1 3.3 3 0 0 3 3 3 0 CarboxypepD_reg-like domain FAD_binding_3 PF01494.19 ELR22458.1 - 8.6e-08 31.8 0.1 0.00065 19.0 0.0 3.3 3 0 0 3 3 3 1 FAD binding domain FAD_binding_2 PF00890.24 ELR22458.1 - 3.1e-05 23.2 3.7 6.1e-05 22.3 0.6 2.3 2 0 0 2 2 2 1 FAD binding domain HI0933_like PF03486.14 ELR22458.1 - 0.0002 20.2 0.1 0.00031 19.6 0.1 1.3 1 0 0 1 1 1 1 HI0933-like protein FAD_oxidored PF12831.7 ELR22458.1 - 0.0006 19.3 2.2 0.0018 17.7 2.2 1.8 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 ELR22458.1 - 0.015 14.6 1.1 0.025 13.8 0.1 1.9 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 ELR22458.1 - 0.021 13.9 0.3 0.41 9.6 0.0 2.5 2 0 0 2 2 2 0 Lycopene cyclase protein DAO PF01266.24 ELR22458.1 - 0.03 13.9 0.2 0.03 13.9 0.2 2.1 2 0 0 2 2 1 0 FAD dependent oxidoreductase Thi4 PF01946.17 ELR22458.1 - 0.032 13.5 0.0 0.081 12.1 0.0 1.6 1 0 0 1 1 1 0 Thi4 family Pyr_redox_3 PF13738.6 ELR22458.1 - 0.06 12.6 0.0 0.098 11.9 0.0 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Ribosomal_60s PF00428.19 ELR22458.1 - 1.2 9.8 5.4 2.5 8.7 0.0 3.8 4 0 0 4 4 4 0 60s Acidic ribosomal protein AlaDh_PNT_C PF01262.21 ELR22458.1 - 2.2 7.5 6.6 0.28 10.4 0.7 2.5 2 1 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain DEP PF00610.21 ELR22459.1 - 7.4e-19 67.6 0.1 1.5e-18 66.6 0.1 1.5 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) Usp PF00582.26 ELR22459.1 - 2.2e-05 25.0 0.3 0.00013 22.4 0.0 2.3 2 0 0 2 2 2 1 Universal stress protein family SET PF00856.28 ELR22460.1 - 3.1e-16 60.2 0.0 9.7e-16 58.6 0.0 1.9 1 1 0 1 1 1 1 SET domain SDA1 PF05285.12 ELR22460.1 - 1.2e-06 28.2 14.8 1.2e-06 28.2 14.8 1.9 2 0 0 2 2 2 1 SDA1 SAPS PF04499.15 ELR22460.1 - 0.3 9.8 4.2 0.45 9.2 4.2 1.3 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein BUD22 PF09073.10 ELR22460.1 - 0.31 10.3 22.2 0.18 11.1 17.3 2.0 2 0 0 2 2 2 0 BUD22 SAM_1 PF00536.30 ELR22461.1 - 0.00022 21.6 0.1 0.00054 20.4 0.1 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 ELR22461.1 - 0.00076 19.5 0.0 0.0014 18.7 0.0 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) RasGEF PF00617.19 ELR22463.1 - 6.1e-40 137.3 0.1 1.1e-39 136.5 0.1 1.3 1 0 0 1 1 1 1 RasGEF domain PBP1_TM PF14812.6 ELR22463.1 - 4.8 7.6 11.3 7.3 7.0 2.8 2.9 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal RhoGEF PF00621.20 ELR22464.1 - 1.9e-29 103.2 0.0 3.9e-29 102.2 0.0 1.6 1 0 0 1 1 1 1 RhoGEF domain PH PF00169.29 ELR22464.1 - 0.0014 19.2 1.4 0.0031 18.0 0.3 2.0 1 1 1 2 2 2 1 PH domain Focal_AT PF03623.13 ELR22464.1 - 0.0046 16.9 0.1 0.24 11.4 0.1 3.3 3 0 0 3 3 3 1 Focal adhesion targeting region Methyltransf_20 PF12147.8 ELR22464.1 - 0.12 11.5 0.1 0.22 10.6 0.1 1.3 1 0 0 1 1 1 0 Putative methyltransferase BUD22 PF09073.10 ELR22466.1 - 0.56 9.5 6.8 1.3 8.3 6.8 1.6 1 0 0 1 1 1 0 BUD22 GTP_EFTU PF00009.27 ELR22467.1 - 2.9e-34 118.3 0.0 2.9e-34 118.3 0.0 2.5 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain IF-2 PF11987.8 ELR22467.1 - 1.1e-18 67.3 0.5 3.1e-18 65.8 0.1 2.1 2 0 0 2 2 2 1 Translation-initiation factor 2 GTP_EFTU_D2 PF03144.25 ELR22467.1 - 1.2e-12 48.0 11.3 3.7e-09 36.8 0.2 4.0 4 0 0 4 4 4 2 Elongation factor Tu domain 2 GTP_EFTU_D4 PF14578.6 ELR22467.1 - 2e-12 46.9 5.2 2e-11 43.6 3.9 2.9 2 1 0 2 2 2 1 Elongation factor Tu domain 4 MMR_HSR1 PF01926.23 ELR22467.1 - 7.2e-07 29.3 1.1 6.3e-06 26.3 0.0 3.1 3 0 0 3 3 3 1 50S ribosome-binding GTPase Roc PF08477.13 ELR22467.1 - 0.00027 21.1 0.0 0.00068 19.9 0.0 1.7 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase ATP_bind_1 PF03029.17 ELR22467.1 - 0.0071 16.2 0.0 0.018 14.8 0.0 1.7 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein AAA_22 PF13401.6 ELR22467.1 - 0.046 14.0 0.8 0.17 12.2 0.0 2.4 2 0 0 2 2 2 0 AAA domain DnaJ_C PF01556.18 ELR22468.1 - 2.9e-42 144.2 0.2 4e-42 143.8 0.2 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 ELR22468.1 - 4.7e-25 87.5 1.2 8.8e-25 86.6 1.2 1.5 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.19 ELR22468.1 - 5.8e-16 58.6 11.5 1.1e-15 57.8 11.5 1.5 1 0 0 1 1 1 1 DnaJ central domain Anti-TRAP PF15777.5 ELR22468.1 - 0.00019 21.3 5.6 0.14 12.2 1.0 2.6 2 0 0 2 2 2 2 Tryptophan RNA-binding attenuator protein inhibitory protein HypA PF01155.19 ELR22468.1 - 0.001 19.1 3.6 0.25 11.4 0.8 2.3 2 0 0 2 2 2 2 Hydrogenase/urease nickel incorporation, metallochaperone, hypA DZR PF12773.7 ELR22468.1 - 1.8 8.7 9.4 13 5.9 9.5 2.1 1 1 0 1 1 1 0 Double zinc ribbon zinc-ribbons_6 PF07191.12 ELR22468.1 - 2.3 8.2 6.7 14 5.8 6.6 2.2 1 1 0 1 1 1 0 zinc-ribbons zf_CopZ PF18423.1 ELR22468.1 - 6.2 6.9 6.6 13 5.8 0.2 3.0 2 1 1 3 3 3 0 Zinc binding domain EF-hand_7 PF13499.6 ELR22469.1 - 7.6e-15 55.1 0.2 8.3e-15 55.0 0.2 1.0 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.32 ELR22469.1 - 1e-14 52.9 0.4 1.9e-07 30.1 0.0 2.5 2 1 1 3 3 3 2 EF hand EF-hand_8 PF13833.6 ELR22469.1 - 8.6e-13 47.9 0.3 1.5e-12 47.1 0.1 1.5 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 ELR22469.1 - 4.3e-12 44.9 0.7 1.9e-07 30.4 0.0 2.8 1 1 1 2 2 2 2 EF-hand domain EF-hand_5 PF13202.6 ELR22469.1 - 2e-08 33.4 0.4 0.00044 19.6 0.0 2.4 2 0 0 2 2 2 2 EF hand EF-hand_9 PF14658.6 ELR22469.1 - 1.1e-05 25.6 0.0 1.3e-05 25.5 0.0 1.1 1 0 0 1 1 1 1 EF-hand domain SPARC_Ca_bdg PF10591.9 ELR22469.1 - 9e-05 22.8 0.1 0.00011 22.5 0.1 1.1 1 0 0 1 1 1 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 ELR22469.1 - 0.0014 18.5 0.2 0.0016 18.3 0.2 1.1 1 0 0 1 1 1 1 Cytoskeletal-regulatory complex EF hand EF-hand_11 PF08976.11 ELR22469.1 - 0.0068 17.3 0.0 0.0071 17.2 0.0 1.0 1 0 0 1 1 1 1 EF-hand domain Dockerin_1 PF00404.18 ELR22469.1 - 0.014 15.6 0.2 0.21 11.8 0.6 2.0 1 1 1 2 2 2 0 Dockerin type I domain DUF1296 PF06972.11 ELR22469.1 - 0.042 14.0 0.1 0.15 12.2 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1296) YqeY PF09424.10 ELR22469.1 - 0.045 13.8 0.4 0.051 13.6 0.4 1.1 1 0 0 1 1 1 0 Yqey-like protein PITH PF06201.13 ELR22470.1 - 5.2e-41 140.4 0.9 9.1e-41 139.6 0.7 1.5 2 0 0 2 2 2 1 PITH domain Thioredoxin PF00085.20 ELR22470.1 - 1.5e-25 89.1 0.0 2.9e-25 88.3 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.6 ELR22470.1 - 9.6e-06 26.0 0.0 0.00014 22.3 0.0 2.4 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_9 PF14595.6 ELR22470.1 - 5.2e-05 23.0 0.0 0.0001 22.1 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_8 PF13905.6 ELR22470.1 - 6.6e-05 23.2 0.3 0.00036 20.8 0.0 2.2 2 1 0 2 2 2 1 Thioredoxin-like Thioredoxin_7 PF13899.6 ELR22470.1 - 0.00064 19.9 0.1 0.0016 18.6 0.1 1.6 1 0 0 1 1 1 1 Thioredoxin-like Glutaredoxin PF00462.24 ELR22470.1 - 0.0025 18.0 0.1 0.0058 16.8 0.1 1.7 1 0 0 1 1 1 1 Glutaredoxin AhpC-TSA PF00578.21 ELR22470.1 - 0.011 15.6 0.1 0.042 13.8 0.0 1.8 1 1 1 2 2 2 0 AhpC/TSA family TraF PF13728.6 ELR22470.1 - 0.016 15.0 0.0 0.026 14.4 0.0 1.2 1 0 0 1 1 1 0 F plasmid transfer operon protein OST3_OST6 PF04756.13 ELR22470.1 - 0.023 14.1 0.0 0.034 13.5 0.0 1.3 1 0 0 1 1 1 0 OST3 / OST6 family, transporter family Redoxin PF08534.10 ELR22470.1 - 0.057 13.1 0.2 0.73 9.5 0.1 2.2 1 1 1 2 2 2 0 Redoxin RasGAP PF00616.19 ELR22471.1 - 3.4e-15 56.3 0.0 6.2e-13 48.9 0.0 2.4 1 1 1 2 2 2 2 GTPase-activator protein for Ras-like GTPase PBP1_TM PF14812.6 ELR22471.1 - 3.8 7.9 10.8 9 6.7 0.3 2.7 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal V4R PF02830.18 ELR22472.1 - 3.1e-08 33.5 3.1 5.6e-08 32.7 3.1 1.4 1 0 0 1 1 1 1 V4R domain V4R PF02830.18 ELR22473.1 - 6.2e-08 32.5 0.9 1.3e-07 31.5 0.9 1.5 1 0 0 1 1 1 1 V4R domain Sds3 PF08598.11 ELR22474.1 - 3.2e-21 76.4 17.1 4e-20 72.7 17.1 2.0 1 1 0 1 1 1 1 Sds3-like DUF5381 PF17353.2 ELR22475.1 - 1.3 8.7 6.7 10 5.9 6.9 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF5381) RasGAP PF00616.19 ELR22477.1 - 5.1e-24 85.1 4.2 1.5e-17 64.0 0.0 3.1 2 1 1 3 3 3 2 GTPase-activator protein for Ras-like GTPase START PF01852.19 ELR22477.1 - 3.4e-06 26.6 0.1 4e-05 23.1 0.0 2.2 2 0 0 2 2 2 1 START domain Rap_GAP PF02145.15 ELR22478.1 - 1.1e-40 139.2 0.2 1.4e-40 138.9 0.2 1.1 1 0 0 1 1 1 1 Rap/ran-GAP HA PF03457.14 ELR22480.1 - 9.9e-16 57.8 2.4 9.9e-16 57.8 2.4 1.8 2 0 0 2 2 2 1 Helicase associated domain DUF2457 PF10446.9 ELR22480.1 - 1.2 8.2 20.8 2.6 7.1 20.8 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) DHR10 PF18595.1 ELR22480.1 - 1.8 8.6 8.5 1.9 8.6 2.1 2.5 2 0 0 2 2 2 0 Designed helical repeat protein 10 domain Bac_chlorC PF02043.17 ELR22482.1 - 0.14 12.1 0.0 0.24 11.4 0.0 1.4 1 0 0 1 1 1 0 Bacteriochlorophyll C binding protein Epimerase PF01370.21 ELR22483.1 - 2.7e-24 86.0 0.0 7.5e-24 84.5 0.0 1.7 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 ELR22483.1 - 6.2e-20 71.3 0.0 8.2e-20 70.9 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.6 ELR22483.1 - 6.7e-14 52.2 0.0 1.6e-13 51.0 0.0 1.6 2 0 0 2 2 2 1 NAD(P)H-binding NAD_binding_4 PF07993.12 ELR22483.1 - 9.7e-12 44.6 0.0 2.3e-09 36.8 0.0 2.1 1 1 0 1 1 1 1 Male sterility protein NmrA PF05368.13 ELR22483.1 - 8.3e-11 41.9 0.0 6.5e-10 39.0 0.0 2.1 2 1 0 2 2 2 1 NmrA-like family GDP_Man_Dehyd PF16363.5 ELR22483.1 - 3.3e-10 39.9 0.0 1.6e-09 37.6 0.0 1.9 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase Polysacc_synt_2 PF02719.15 ELR22483.1 - 0.0027 16.9 0.0 0.0042 16.3 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein adh_short PF00106.25 ELR22483.1 - 0.012 15.0 0.1 0.04 13.4 0.1 1.9 1 1 0 1 1 1 0 short chain dehydrogenase KR PF08659.10 ELR22483.1 - 0.015 15.2 1.3 0.32 10.9 1.3 2.2 1 1 0 1 1 1 0 KR domain RmlD_sub_bind PF04321.17 ELR22483.1 - 0.074 12.1 0.1 0.34 10.0 0.0 1.9 2 0 0 2 2 2 0 RmlD substrate binding domain Epimerase PF01370.21 ELR22484.1 - 2.5e-24 86.1 0.0 6.9e-24 84.6 0.0 1.7 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 ELR22484.1 - 6.9e-20 71.2 0.0 9.1e-20 70.8 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.6 ELR22484.1 - 7.6e-14 52.0 0.0 1.6e-13 50.9 0.0 1.5 2 0 0 2 2 2 1 NAD(P)H-binding NAD_binding_4 PF07993.12 ELR22484.1 - 9.9e-12 44.6 0.0 2.3e-09 36.8 0.0 2.1 1 1 0 1 1 1 1 Male sterility protein NmrA PF05368.13 ELR22484.1 - 1.3e-10 41.2 0.0 6.6e-10 38.9 0.0 2.0 2 1 0 2 2 2 1 NmrA-like family GDP_Man_Dehyd PF16363.5 ELR22484.1 - 3.3e-10 39.9 0.0 1.6e-09 37.6 0.0 1.9 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase Polysacc_synt_2 PF02719.15 ELR22484.1 - 0.0027 16.9 0.0 0.0042 16.3 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein adh_short PF00106.25 ELR22484.1 - 0.012 15.0 0.1 0.041 13.3 0.1 1.9 1 1 0 1 1 1 0 short chain dehydrogenase KR PF08659.10 ELR22484.1 - 0.016 15.2 1.3 0.32 10.9 1.3 2.1 1 1 0 1 1 1 0 KR domain RmlD_sub_bind PF04321.17 ELR22484.1 - 0.077 12.1 0.1 0.34 10.0 0.0 1.9 2 0 0 2 2 2 0 RmlD substrate binding domain Beta_helix PF13229.6 ELR22485.1 - 1.1e-13 51.3 40.8 1.9e-08 34.3 23.3 2.9 1 1 2 3 3 3 2 Right handed beta helix region MMR_HSR1 PF01926.23 ELR22486.1 - 1.7e-39 134.4 7.0 3.1e-19 69.1 0.0 2.9 2 1 0 2 2 2 2 50S ribosome-binding GTPase KH_dom-like PF14714.6 ELR22486.1 - 1.3e-26 92.8 1.8 3.7e-26 91.3 0.9 2.2 2 0 0 2 2 2 1 KH-domain-like of EngA bacterial GTPase enzymes, C-terminal GTP_EFTU PF00009.27 ELR22486.1 - 4.6e-19 68.7 3.3 1.2e-08 34.7 2.8 3.8 3 2 0 3 3 3 2 Elongation factor Tu GTP binding domain FeoB_N PF02421.18 ELR22486.1 - 2e-16 59.9 0.9 0.00017 21.1 0.0 3.4 3 0 0 3 3 3 3 Ferrous iron transport protein B Dynamin_N PF00350.23 ELR22486.1 - 1.8e-15 57.4 0.7 3.5e-12 46.7 0.5 3.2 2 1 0 3 3 3 1 Dynamin family AIG1 PF04548.16 ELR22486.1 - 2.1e-06 27.3 1.6 0.19 11.1 0.0 3.3 3 0 0 3 3 3 2 AIG1 family Ras PF00071.22 ELR22486.1 - 7.5e-06 25.6 8.6 0.0058 16.2 0.3 4.3 4 2 0 4 4 3 2 Ras family RsgA_GTPase PF03193.16 ELR22486.1 - 2.7e-05 24.2 2.5 0.68 9.8 0.0 3.5 3 0 0 3 3 3 2 RsgA GTPase Roc PF08477.13 ELR22486.1 - 9.7e-05 22.6 3.9 1.9 8.7 0.1 4.7 3 2 1 4 4 4 2 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR22486.1 - 0.00016 21.2 0.2 0.8 9.1 0.2 4.1 4 0 0 4 4 4 1 ADP-ribosylation factor family MCM PF00493.23 ELR22486.1 - 0.00035 19.8 0.2 0.28 10.2 0.0 3.1 3 0 0 3 3 3 1 MCM P-loop domain NOG1 PF06858.14 ELR22486.1 - 0.00061 19.5 2.8 0.0046 16.7 0.5 2.5 2 0 0 2 2 2 1 Nucleolar GTP-binding protein 1 (NOG1) ABC_tran PF00005.27 ELR22486.1 - 0.0022 18.5 0.0 4.5 7.8 0.1 2.7 2 0 0 2 2 2 2 ABC transporter TRAP_alpha PF03896.16 ELR22486.1 - 0.037 13.2 5.8 0.087 12.0 5.2 1.8 2 0 0 2 2 2 0 Translocon-associated protein (TRAP), alpha subunit cobW PF02492.19 ELR22486.1 - 0.073 12.6 3.4 1.1 8.8 0.2 3.4 3 1 1 4 4 4 0 CobW/HypB/UreG, nucleotide-binding domain Drc1-Sld2 PF11719.8 ELR22486.1 - 0.095 12.2 6.1 0.19 11.2 6.1 1.4 1 0 0 1 1 1 0 DNA replication and checkpoint protein MobB PF03205.14 ELR22486.1 - 0.25 11.3 3.9 2.6 7.9 0.2 3.2 3 1 0 3 3 3 0 Molybdopterin guanine dinucleotide synthesis protein B CDC45 PF02724.14 ELR22486.1 - 0.41 8.9 5.7 0.71 8.1 5.7 1.4 1 0 0 1 1 1 0 CDC45-like protein NOA36 PF06524.12 ELR22486.1 - 1.7 7.9 10.5 2.7 7.2 10.5 1.2 1 0 0 1 1 1 0 NOA36 protein RNA_helicase PF00910.22 ELR22486.1 - 2.5 8.5 4.4 39 4.7 0.0 3.2 4 0 0 4 4 3 0 RNA helicase TGT PF01702.18 ELR22487.1 - 1.7e-32 113.0 0.1 3.1e-25 89.1 0.0 2.0 1 1 1 2 2 2 2 Queuine tRNA-ribosyltransferase zf-Tim10_DDP PF02953.15 ELR22488.1 - 5.3e-16 58.0 2.6 6.7e-16 57.7 2.6 1.2 1 0 0 1 1 1 1 Tim10/DDP family zinc finger Acetyltransf_16 PF05301.11 ELR22488.1 - 0.022 14.5 0.0 0.024 14.4 0.0 1.2 1 0 0 1 1 1 0 GNAT acetyltransferase, Mec-17 ADH_zinc_N PF00107.26 ELR22489.1 - 1.1e-21 77.1 1.9 1.3e-21 76.9 0.6 1.7 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 ELR22489.1 - 3.8e-19 70.1 0.4 7.7e-19 69.1 0.4 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 ELR22489.1 - 6.3e-08 32.5 0.0 1.5e-07 31.2 0.0 1.7 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain adh_short PF00106.25 ELR22489.1 - 0.44 10.0 3.7 0.37 10.2 1.8 1.9 1 1 0 1 1 1 0 short chain dehydrogenase Nop53 PF07767.11 ELR22490.1 - 1.4e-32 113.6 32.9 1.4e-32 113.6 32.9 2.2 1 1 1 2 2 2 1 Nop53 (60S ribosomal biogenesis) PUB PF09409.10 ELR22491.1 - 1.1e-06 28.5 0.0 0.001 19.0 0.0 2.2 2 0 0 2 2 2 2 PUB domain Cwf_Cwc_15 PF04889.12 ELR22492.1 - 0.13 11.9 27.8 0.25 11.1 22.0 2.2 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein SEEEED PF14797.6 ELR22492.1 - 1.4 9.1 35.3 0.71 10.0 29.6 2.4 2 0 0 2 2 2 0 Serine-rich region of AP3B1, clathrin-adaptor complex PDZ_3 PF17815.1 ELR22493.1 - 2.5e-05 24.2 0.0 2.8e-05 24.0 0.0 1.0 1 0 0 1 1 1 1 PDZ domain zf-C3H2C3 PF17122.5 ELR22494.1 - 0.0016 18.4 8.6 0.0044 17.0 8.6 1.8 1 0 0 1 1 1 1 Zinc-finger zf-RING_11 PF17123.5 ELR22494.1 - 0.018 14.8 0.3 0.018 14.8 0.3 1.8 2 0 0 2 2 2 0 RING-like zinc finger zf-RING_2 PF13639.6 ELR22494.1 - 0.088 13.2 7.2 0.23 11.8 7.2 1.8 1 0 0 1 1 1 0 Ring finger domain zf-rbx1 PF12678.7 ELR22494.1 - 0.094 13.0 3.9 0.23 11.8 3.9 1.6 1 0 0 1 1 1 0 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 ELR22494.1 - 0.2 11.7 2.1 0.53 10.4 2.1 1.6 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_2 PF13923.6 ELR22494.1 - 0.69 9.8 7.2 1.4 8.9 7.2 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ELR22494.1 - 1.1 9.3 7.2 2.1 8.4 7.2 1.5 1 0 0 1 1 1 0 zinc-RING finger domain Borrelia_P83 PF05262.11 ELR22494.1 - 5.4 5.4 15.2 9.7 4.6 15.2 1.3 1 0 0 1 1 1 0 Borrelia P83/100 protein FMN_red PF03358.15 ELR22495.1 - 2.9e-12 46.6 0.0 4.9e-12 45.9 0.0 1.4 1 0 0 1 1 1 1 NADPH-dependent FMN reductase Flavodoxin_2 PF02525.17 ELR22495.1 - 2.6e-08 33.8 0.0 3.3e-08 33.5 0.0 1.2 1 0 0 1 1 1 1 Flavodoxin-like fold Flavodoxin_5 PF12724.7 ELR22495.1 - 3e-05 24.3 0.2 0.00079 19.7 0.0 2.2 1 1 1 2 2 2 1 Flavodoxin domain Flavodoxin_1 PF00258.25 ELR22495.1 - 6.8e-05 23.1 0.1 0.00011 22.4 0.1 1.3 1 0 0 1 1 1 1 Flavodoxin F-box-like PF12937.7 ELR22496.1 - 9.3e-10 38.3 2.4 2e-09 37.2 2.4 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ELR22496.1 - 1.2e-07 31.4 0.5 2.7e-07 30.3 0.5 1.6 1 0 0 1 1 1 1 F-box domain GlcNAc PF11397.8 ELR22496.1 - 0.025 14.0 1.2 0.032 13.7 1.2 1.1 1 0 0 1 1 1 0 Glycosyltransferase (GlcNAc) APCDDC PF14921.6 ELR22496.1 - 0.026 14.0 0.3 0.036 13.5 0.3 1.1 1 0 0 1 1 1 0 Adenomatosis polyposis coli down-regulated 1 SnoaL_2 PF12680.7 ELR22497.1 - 1.5e-05 25.5 0.0 2.6e-05 24.8 0.0 1.4 1 1 0 1 1 1 1 SnoaL-like domain RNA_ligase PF09414.10 ELR22498.1 - 1.7e-17 64.2 0.0 4.4e-17 62.9 0.0 1.7 1 1 0 1 1 1 1 RNA ligase T4_Rnl2_C PF18043.1 ELR22498.1 - 1.9e-14 53.5 0.4 3.9e-14 52.6 0.4 1.5 1 0 0 1 1 1 1 T4 RNA ligase 2 C-terminal TCTP PF00838.17 ELR22498.1 - 0.071 13.5 0.7 0.11 12.8 0.7 1.4 1 0 0 1 1 1 0 Translationally controlled tumour protein PH PF00169.29 ELR22499.1 - 9.7e-20 71.0 0.0 1.3e-19 70.6 0.0 1.2 1 0 0 1 1 1 1 PH domain PH_3 PF14593.6 ELR22499.1 - 1.2e-05 25.3 0.0 2.5e-05 24.3 0.0 1.5 1 1 0 1 1 1 1 PH domain PH_8 PF15409.6 ELR22499.1 - 0.00011 22.4 0.0 0.00024 21.3 0.0 1.6 1 1 0 1 1 1 1 Pleckstrin homology domain PH_11 PF15413.6 ELR22499.1 - 0.073 13.5 0.1 2 8.9 0.1 2.2 1 1 0 1 1 1 0 Pleckstrin homology domain PH_2 PF08458.10 ELR22499.1 - 0.096 13.0 0.0 0.19 12.1 0.0 1.5 1 0 0 1 1 1 0 Plant pleckstrin homology-like region PUCC PF03209.15 ELR22499.1 - 0.34 9.9 0.8 7.4 5.5 0.0 2.0 2 0 0 2 2 2 0 PUCC protein TFIIA PF03153.13 ELR22499.1 - 1.7 8.6 10.8 2 8.3 10.8 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Abhydrolase_3 PF07859.13 ELR22501.1 - 3e-34 118.8 0.0 3.2e-23 82.7 0.0 3.1 3 0 0 3 3 3 2 alpha/beta hydrolase fold Say1_Mug180 PF10340.9 ELR22501.1 - 8e-08 31.5 0.0 4.2e-06 25.9 0.0 2.4 3 0 0 3 3 3 2 Steryl acetyl hydrolase tRNA_synt_1c_R2 PF04557.15 ELR22501.1 - 0.018 15.9 7.1 0.16 12.9 3.8 2.8 2 0 0 2 2 2 0 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2 Poxvirus_B22R PF04395.12 ELR22501.1 - 4.5 6.8 7.5 9.9 5.6 0.6 2.6 2 0 0 2 2 2 0 Poxvirus B22R protein Ank_2 PF12796.7 ELR22502.1 - 3.6e-21 75.5 2.4 1.8e-07 31.6 0.0 4.6 3 1 4 7 7 7 4 Ankyrin repeats (3 copies) Ank_3 PF13606.6 ELR22502.1 - 9.3e-14 50.2 14.8 0.0029 18.0 0.0 7.5 8 0 0 8 8 8 4 Ankyrin repeat Ank PF00023.30 ELR22502.1 - 1.2e-13 50.8 10.8 7.6e-06 26.2 0.0 5.5 5 0 0 5 5 5 3 Ankyrin repeat Ank_4 PF13637.6 ELR22502.1 - 2.6e-13 50.2 3.4 0.042 14.4 0.0 6.6 5 2 2 7 7 7 4 Ankyrin repeats (many copies) Ank_5 PF13857.6 ELR22502.1 - 9.7e-11 41.7 4.6 0.00047 20.4 0.1 6.0 5 1 1 6 6 6 2 Ankyrin repeats (many copies) F-box-like PF12937.7 ELR22502.1 - 4.5e-08 32.9 0.7 1.1e-07 31.6 0.7 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ELR22502.1 - 9.4e-05 22.2 0.1 0.00027 20.7 0.1 1.8 1 0 0 1 1 1 1 F-box domain PTCRA PF15028.6 ELR22503.1 - 0.044 13.5 0.3 0.071 12.8 0.1 1.5 1 1 0 1 1 1 0 Pre-T-cell antigen receptor Methyltransf_16 PF10294.9 ELR22504.1 - 3.7e-14 52.9 0.0 7.9e-14 51.8 0.0 1.6 1 1 0 1 1 1 1 Lysine methyltransferase FAM86 PF14904.6 ELR22504.1 - 3.9e-06 26.9 0.0 8.3e-06 25.8 0.0 1.5 1 0 0 1 1 1 1 Family of unknown function Methyltransf_31 PF13847.6 ELR22504.1 - 0.008 16.0 0.0 0.016 15.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ELR22504.1 - 0.036 14.8 0.0 0.093 13.5 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain DUF3922 PF13059.6 ELR22504.1 - 0.074 13.5 0.1 0.15 12.5 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3992) TIP120 PF08623.10 ELR22505.1 - 4.9e-59 198.9 7.8 2.9e-55 186.6 1.6 6.9 6 2 0 6 6 6 1 TATA-binding protein interacting (TIP20) HEAT_EZ PF13513.6 ELR22505.1 - 6.2e-09 36.2 24.6 0.057 14.0 0.2 10.0 10 2 2 12 12 12 2 HEAT-like repeat HEAT PF02985.22 ELR22505.1 - 1.5e-08 34.1 20.1 0.0073 16.5 0.0 10.1 13 0 0 13 13 11 2 HEAT repeat HEAT_2 PF13646.6 ELR22505.1 - 8.6e-08 32.5 20.3 0.0037 17.6 0.6 7.7 6 2 2 8 8 8 3 HEAT repeats RIX1 PF08167.12 ELR22505.1 - 4.7e-05 23.2 7.6 0.091 12.5 0.1 5.6 5 1 0 5 5 5 2 rRNA processing/ribosome biogenesis MMS19_N PF14500.6 ELR22505.1 - 6.7e-05 22.6 8.6 3.2 7.2 0.0 6.7 5 1 1 7 7 7 2 Dos2-interacting transcription regulator of RNA-Pol-II Vac14_Fab1_bd PF12755.7 ELR22505.1 - 0.022 15.4 5.5 35 5.1 0.0 6.2 6 1 0 6 6 6 0 Vacuolar 14 Fab1-binding region RRN3 PF05327.11 ELR22505.1 - 0.05 12.1 0.1 0.16 10.5 0.1 1.9 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 ParcG PF10274.9 ELR22505.1 - 0.1 12.7 8.6 2.6 8.1 0.1 4.7 5 0 0 5 5 5 0 Parkin co-regulated protein Cnd1 PF12717.7 ELR22505.1 - 0.11 12.6 21.9 4.6 7.3 0.0 7.9 6 3 2 8 8 8 0 non-SMC mitotic condensation complex subunit 1 Ipi1_N PF12333.8 ELR22505.1 - 0.12 12.9 1.7 53 4.5 0.0 4.8 3 1 2 5 5 5 0 Rix1 complex component involved in 60S ribosome maturation COX5A PF02284.16 ELR22505.1 - 0.2 11.6 2.6 0.85 9.7 0.1 3.1 3 1 1 4 4 4 0 Cytochrome c oxidase subunit Va Mon1 PF03164.14 ELR22506.1 - 1.2e-91 307.8 5.0 7.5e-62 209.7 0.9 3.1 2 1 1 3 3 3 3 Trafficking protein Mon1 Med3 PF11593.8 ELR22506.1 - 2.2 7.4 10.2 4.1 6.5 10.2 1.4 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal Macoilin PF09726.9 ELR22506.1 - 2.6 6.5 8.2 3.6 6.0 8.2 1.2 1 0 0 1 1 1 0 Macoilin family Apt1 PF10351.9 ELR22506.1 - 4.5 6.0 9.8 6.3 5.5 9.8 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain IGR PF09597.10 ELR22507.1 - 7.5e-18 64.4 1.4 1.2e-17 63.7 1.4 1.3 1 0 0 1 1 1 1 IGR protein motif Pex2_Pex12 PF04757.14 ELR22508.1 - 7.8e-25 87.8 1.3 1.1e-24 87.2 1.3 1.2 1 0 0 1 1 1 1 Pex2 / Pex12 amino terminal region zf-RING_UBOX PF13445.6 ELR22508.1 - 0.0021 18.1 5.2 0.0044 17.0 5.2 1.5 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4 PF00097.25 ELR22508.1 - 0.0028 17.5 6.0 0.0061 16.4 6.0 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 ELR22508.1 - 0.0056 16.5 4.8 0.01 15.7 4.8 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 ELR22508.1 - 0.011 16.0 6.1 0.024 15.0 6.1 1.6 1 0 0 1 1 1 0 Ring finger domain zf-C3HC4_2 PF13923.6 ELR22508.1 - 0.026 14.4 5.9 0.056 13.3 5.9 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 ELR22508.1 - 0.066 13.4 3.9 0.15 12.2 3.9 1.6 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING Prok-RING_4 PF14447.6 ELR22508.1 - 0.13 12.2 5.8 0.27 11.1 5.8 1.5 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 ELR22508.1 - 0.18 11.8 5.8 0.37 10.8 5.8 1.5 1 0 0 1 1 1 0 zinc-RING finger domain BolA PF01722.18 ELR22511.1 - 8.1e-17 61.3 0.0 1.1e-16 60.8 0.0 1.3 1 1 0 1 1 1 1 BolA-like protein zf-Tim10_DDP PF02953.15 ELR22512.1 - 3.3e-08 33.1 4.2 4.1e-08 32.8 4.2 1.2 1 0 0 1 1 1 1 Tim10/DDP family zinc finger SET PF00856.28 ELR22513.1 - 1.2e-22 81.1 0.2 1.2e-22 81.1 0.2 6.1 3 3 0 3 3 3 1 SET domain AWS PF17907.1 ELR22513.1 - 1.5e-11 44.1 10.5 3.8e-11 42.8 10.5 1.6 1 0 0 1 1 1 1 AWS domain AF-4 PF05110.13 ELR22513.1 - 0.42 8.6 97.3 1.1 7.2 34.4 2.5 2 0 0 2 2 2 0 AF-4 proto-oncoprotein YbaB_DNA_bd PF02575.16 ELR22514.1 - 1.3e-06 28.5 0.6 2e-06 28.0 0.6 1.2 1 0 0 1 1 1 1 YbaB/EbfC DNA-binding family LRR_4 PF12799.7 ELR22516.1 - 0.017 15.6 0.2 30 5.2 0.0 3.7 3 1 3 6 6 6 0 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 ELR22516.1 - 0.071 12.9 1.4 5.8 6.8 0.0 3.3 3 0 0 3 3 3 0 Leucine rich repeat C2 PF00168.30 ELR22517.1 - 3e-06 27.5 0.0 3.9e-06 27.1 0.0 1.2 1 0 0 1 1 1 1 C2 domain SBDS PF01172.18 ELR22518.1 - 3e-21 75.3 0.1 6e-21 74.3 0.1 1.5 1 0 0 1 1 1 1 Shwachman-Bodian-Diamond syndrome (SBDS) protein SBDS_C PF09377.10 ELR22518.1 - 6.8e-17 61.6 0.2 1e-16 61.0 0.2 1.2 1 0 0 1 1 1 1 SBDS protein C-terminal domain DUF1949 PF09186.11 ELR22518.1 - 0.0058 16.5 0.0 0.012 15.5 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1949) RGS-like PF09128.11 ELR22518.1 - 0.022 14.5 0.1 0.028 14.1 0.1 1.2 1 0 0 1 1 1 0 Regulator of G protein signalling-like domain EFG_C PF00679.24 ELR22518.1 - 0.051 13.6 0.3 0.14 12.2 0.1 1.7 2 0 0 2 2 2 0 Elongation factor G C-terminus GtrA PF04138.14 ELR22519.1 - 0.16 12.2 6.2 0.12 12.6 4.8 1.5 1 1 0 1 1 1 0 GtrA-like protein CbtB PF09489.10 ELR22519.1 - 6.7 6.9 9.3 0.77 9.9 0.4 3.2 3 0 0 3 3 3 0 Probable cobalt transporter subunit (CbtB) zf-RanBP PF00641.18 ELR22520.1 - 4.2e-21 74.0 31.5 6.1e-08 31.8 1.6 4.1 4 0 0 4 4 4 3 Zn-finger in Ran binding protein and others DZR PF12773.7 ELR22520.1 - 0.028 14.5 19.4 0.69 10.0 10.6 3.2 2 1 1 3 3 3 0 Double zinc ribbon TackOD1 PF18551.1 ELR22520.1 - 0.37 10.4 15.7 4.9 6.8 1.4 3.0 3 0 0 3 3 3 0 Thaumarchaeal output domain 1 HypA PF01155.19 ELR22520.1 - 4.5 7.3 15.4 12 6.0 0.9 3.1 3 0 0 3 3 3 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Zn_ribbon_SprT PF17283.2 ELR22520.1 - 4.6 7.2 21.7 1.9 8.4 3.3 3.6 3 1 0 3 3 3 0 SprT-like zinc ribbon domain zf-C5HC2 PF02928.16 ELR22520.1 - 6 7.3 14.4 12 6.4 1.4 3.1 3 0 0 3 3 3 0 C5HC2 zinc finger zinc-ribbon_6 PF10005.9 ELR22520.1 - 7.9 7.2 16.6 8.8 7.1 0.7 3.1 3 0 0 3 3 3 0 zinc-ribbon domain Oxysterol_BP PF01237.18 ELR22522.1 - 9.6e-48 162.9 0.0 2.8e-37 128.5 0.0 2.1 1 1 1 2 2 2 2 Oxysterol-binding protein DGF-1_C PF11040.8 ELR22522.1 - 0.33 11.0 2.8 13 5.8 0.0 2.6 2 1 0 2 2 2 0 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus PLDc_2 PF13091.6 ELR22523.1 - 1.4e-15 57.3 0.0 6.4e-07 29.3 0.0 3.1 2 1 0 2 2 2 2 PLD-like domain PLDc PF00614.22 ELR22523.1 - 0.00056 20.0 0.5 0.37 11.1 0.1 2.4 2 0 0 2 2 2 2 Phospholipase D Active site motif HisKA PF00512.25 ELR22524.1 - 1.4e-15 57.0 1.4 2.6e-15 56.2 0.3 2.1 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain PH_10 PF15411.6 ELR22525.1 - 0.042 14.1 0.0 0.072 13.4 0.0 1.4 1 0 0 1 1 1 0 Pleckstrin homology domain FSAP_sig_propep PF03032.15 ELR22525.1 - 0.25 11.4 1.2 7.6 6.6 0.1 2.7 2 0 0 2 2 2 0 Frog skin active peptide family signal and propeptide RNase_HII PF01351.18 ELR22527.1 - 1e-06 28.8 0.0 1.3e-06 28.4 0.0 1.2 1 0 0 1 1 1 1 Ribonuclease HII Response_reg PF00072.24 ELR22528.1 - 4e-07 30.2 0.1 3.7e-05 23.8 0.1 2.7 1 1 0 1 1 1 1 Response regulator receiver domain CLU PF13236.6 ELR22529.1 - 1.5e-52 178.6 0.0 3.5e-52 177.4 0.0 1.6 2 0 0 2 2 2 1 Clustered mitochondria eIF3_p135 PF12807.7 ELR22529.1 - 0.00016 21.7 6.1 0.00016 21.7 2.3 2.8 2 1 0 2 2 2 1 Translation initiation factor eIF3 subunit 135 Chorein_N PF12624.7 ELR22530.1 - 2.4e-17 63.1 0.1 7e-17 61.6 0.1 1.8 1 0 0 1 1 1 1 N-terminal region of Chorein or VPS13 ATG16 PF08614.11 ELR22530.1 - 0.0045 17.2 12.5 0.0054 17.0 6.2 3.1 3 0 0 3 3 3 1 Autophagy protein 16 (ATG16) V-SNARE PF05008.15 ELR22530.1 - 0.017 15.5 3.0 0.052 13.9 3.0 1.9 1 0 0 1 1 1 0 Vesicle transport v-SNARE protein N-terminus DUF4472 PF14739.6 ELR22530.1 - 0.047 14.4 4.7 0.19 12.5 4.7 2.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4472) NIR_SIR_ferr PF03460.17 ELR22530.1 - 0.087 12.7 0.0 15 5.5 0.0 2.8 2 0 0 2 2 2 0 Nitrite/Sulfite reductase ferredoxin-like half domain ZapB PF06005.12 ELR22530.1 - 6 7.4 9.2 11 6.5 5.4 2.9 2 0 0 2 2 2 0 Cell division protein ZapB YabA PF06156.13 ELR22530.1 - 9.6 6.9 7.2 11 6.7 1.8 3.5 3 1 0 3 3 3 0 Initiation control protein YabA DUF5325 PF17259.2 ELR22531.1 - 6.5 6.7 8.9 0.44 10.5 2.1 2.5 3 0 0 3 3 3 0 Family of unknown function (DUF5325) Actin PF00022.19 ELR22532.1 - 1.6e-07 30.3 0.0 1.8e-07 30.1 0.0 1.0 1 0 0 1 1 1 1 Actin Actin PF00022.19 ELR22533.1 - 4.4e-61 206.7 0.0 1.3e-60 205.1 0.0 1.7 1 1 0 1 1 1 1 Actin 2OG-FeII_Oxy_3 PF13640.6 ELR22533.1 - 0.00018 22.3 0.0 0.00043 21.1 0.0 1.6 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Exo_endo_phos PF03372.23 ELR22535.1 - 1.1e-23 84.0 0.6 1.3e-23 83.7 0.6 1.1 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.6 ELR22535.1 - 0.00051 19.9 0.1 0.0016 18.3 0.0 1.9 2 1 0 2 2 2 1 Endonuclease-reverse transcriptase FAM176 PF14851.6 ELR22535.1 - 0.64 9.7 3.2 1 9.0 3.2 1.3 1 0 0 1 1 1 0 FAM176 family DTHCT PF08070.11 ELR22535.1 - 1.2 9.9 21.0 16 6.3 21.6 2.0 1 1 0 1 1 1 0 DTHCT (NUC029) region Mob1_phocein PF03637.17 ELR22536.1 - 1.6e-71 239.8 0.1 1.8e-71 239.6 0.1 1.0 1 0 0 1 1 1 1 Mob1/phocein family F-box-like PF12937.7 ELR22537.1 - 0.0014 18.5 3.0 0.0023 17.8 0.1 2.7 3 0 0 3 3 3 1 F-box-like F-box PF00646.33 ELR22537.1 - 0.009 15.9 0.0 0.022 14.6 0.0 1.6 1 0 0 1 1 1 1 F-box domain F-box_4 PF15966.5 ELR22537.1 - 0.0093 15.8 0.2 0.021 14.7 0.2 1.7 1 1 0 1 1 1 1 F-box Y_phosphatase3 PF13350.6 ELR22538.1 - 2.1e-32 113.0 0.1 8.6e-32 111.0 0.0 2.0 3 0 0 3 3 3 1 Tyrosine phosphatase family Y_phosphatase2 PF03162.13 ELR22538.1 - 0.00021 20.9 0.0 0.00041 20.0 0.0 1.4 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase PF00102.27 ELR22538.1 - 0.0012 18.4 0.0 0.0021 17.7 0.0 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase DUF3439 PF11921.8 ELR22538.1 - 8.9 6.3 10.6 19 5.3 5.8 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF3439) JAB PF01398.21 ELR22539.1 - 4e-18 65.5 0.0 7.6e-18 64.6 0.0 1.5 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease WD40 PF00400.32 ELR22540.1 - 1.7e-24 85.6 14.9 1.3e-07 32.2 0.2 6.5 7 0 0 7 7 7 4 WD domain, G-beta repeat Nup160 PF11715.8 ELR22540.1 - 2.9e-10 39.4 3.6 0.0028 16.4 0.3 4.0 1 1 3 4 4 4 3 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ELR22540.1 - 1.8e-05 24.9 2.0 0.92 9.8 0.0 3.8 1 1 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain F-box-like PF12937.7 ELR22540.1 - 0.011 15.6 0.1 0.031 14.1 0.1 1.7 1 0 0 1 1 1 0 F-box-like eIF2A PF08662.11 ELR22540.1 - 0.019 14.8 0.0 5.4 6.9 0.0 3.1 1 1 1 3 3 3 0 Eukaryotic translation initiation factor eIF2A PALB2_WD40 PF16756.5 ELR22540.1 - 0.081 11.8 1.8 0.12 11.2 0.6 1.8 2 0 0 2 2 2 0 Partner and localizer of BRCA2 WD40 domain F-box PF00646.33 ELR22540.1 - 0.13 12.2 0.0 0.38 10.7 0.0 1.8 1 1 0 1 1 1 0 F-box domain SNARE PF05739.19 ELR22541.1 - 0.00059 19.8 11.0 0.0041 17.1 10.6 2.5 1 1 1 2 2 2 1 SNARE domain TRI5 PF06330.11 ELR22541.1 - 0.0046 15.9 0.0 0.0055 15.6 0.0 1.1 1 0 0 1 1 1 1 Trichodiene synthase (TRI5) Syntaxin PF00804.25 ELR22541.1 - 0.02 14.6 0.0 0.026 14.2 0.0 1.2 1 0 0 1 1 1 0 Syntaxin Synaptobrevin PF00957.21 ELR22541.1 - 3.1 7.7 8.8 40 4.1 8.8 2.1 1 1 0 1 1 1 0 Synaptobrevin RF-1 PF00472.20 ELR22542.1 - 2.2e-21 75.9 0.5 2.2e-21 75.9 0.5 1.9 3 0 0 3 3 3 1 RF-1 domain WRNPLPNID PF15017.6 ELR22542.1 - 1 10.3 15.4 8 7.4 7.5 2.9 2 0 0 2 2 2 0 Putative WW-binding domain and destruction box Sigma70_ner PF04546.13 ELR22542.1 - 5.5 6.8 11.0 1.7 8.5 4.2 2.3 2 0 0 2 2 2 0 Sigma-70, non-essential region Pkinase_Tyr PF07714.17 ELR22543.1 - 6.1e-32 110.9 0.0 1.4e-30 106.5 0.0 2.7 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ELR22543.1 - 4.5e-24 85.2 0.0 2.2e-23 83.0 0.0 2.0 1 1 0 1 1 1 1 Protein kinase domain SAM_1 PF00536.30 ELR22543.1 - 1.8e-05 25.1 0.0 3.9e-05 24.0 0.0 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 ELR22543.1 - 0.00017 21.6 0.0 0.00033 20.7 0.0 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Abhydrolase_4 PF08386.10 ELR22543.1 - 0.00052 20.1 0.0 0.0017 18.5 0.0 1.8 1 0 0 1 1 1 1 TAP-like protein APH PF01636.23 ELR22543.1 - 0.004 17.1 0.2 0.0095 15.9 0.0 1.6 2 0 0 2 2 2 1 Phosphotransferase enzyme family Hydrolase_4 PF12146.8 ELR22543.1 - 0.02 14.2 0.2 0.77 9.0 0.1 2.4 2 0 0 2 2 2 0 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 ELR22543.1 - 0.047 13.3 0.1 0.47 10.1 0.0 2.0 1 1 0 2 2 2 0 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 ELR22543.1 - 0.054 13.0 0.0 0.12 11.9 0.0 1.5 1 0 0 1 1 1 0 Prolyl oligopeptidase family Coilin_N PF15862.5 ELR22543.1 - 0.059 13.2 0.2 0.13 12.1 0.2 1.5 1 0 0 1 1 1 0 Coilin N-terminus FSH1 PF03959.13 ELR22543.1 - 0.1 12.3 0.0 0.18 11.5 0.0 1.4 1 0 0 1 1 1 0 Serine hydrolase (FSH1) Calreticulin PF00262.18 ELR22544.1 - 9.6e-82 274.8 14.6 2e-61 207.9 5.7 2.3 1 1 1 2 2 2 2 Calreticulin family Rhabdo_ncap PF00945.18 ELR22544.1 - 0.13 11.1 4.5 0.19 10.5 4.5 1.2 1 0 0 1 1 1 0 Rhabdovirus nucleocapsid protein CDC45 PF02724.14 ELR22544.1 - 1.5 7.0 11.8 2.3 6.4 11.8 1.2 1 0 0 1 1 1 0 CDC45-like protein SHMT PF00464.19 ELR22546.1 - 2.6e-187 622.3 0.0 3e-187 622.1 0.0 1.0 1 0 0 1 1 1 1 Serine hydroxymethyltransferase Aminotran_1_2 PF00155.21 ELR22546.1 - 5.6e-07 29.1 0.0 1.3e-06 27.9 0.0 1.5 1 1 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.21 ELR22546.1 - 1.2e-05 24.8 0.0 2.2e-05 23.9 0.0 1.5 1 1 0 1 1 1 1 Beta-eliminating lyase Macro PF01661.21 ELR22546.1 - 0.0023 18.0 0.0 1.1 9.3 0.0 3.0 3 0 0 3 3 3 2 Macro domain LOR PF04525.12 ELR22547.1 - 0.00015 21.4 0.1 0.00028 20.6 0.1 1.4 1 1 0 1 1 1 1 LURP-one-related 2-oxoacid_dh PF00198.23 ELR22548.1 - 5.7e-73 245.2 0.0 7.8e-73 244.8 0.0 1.1 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.22 ELR22548.1 - 9.4e-17 60.6 0.1 2.1e-16 59.5 0.1 1.6 1 0 0 1 1 1 1 Biotin-requiring enzyme E3_binding PF02817.17 ELR22548.1 - 2.3e-13 50.3 0.1 7e-13 48.7 0.1 1.9 1 0 0 1 1 1 1 e3 binding domain Biotin_lipoyl_2 PF13533.6 ELR22548.1 - 0.007 16.2 0.0 0.016 15.0 0.0 1.6 1 0 0 1 1 1 1 Biotin-lipoyl like DUF4952 PF16310.5 ELR22548.1 - 0.16 12.2 0.0 0.34 11.2 0.0 1.5 1 0 0 1 1 1 0 Domian of unknown function (DUF4952) Herpes_pp85 PF04637.12 ELR22548.1 - 9.7 4.5 6.0 14 3.9 6.0 1.1 1 0 0 1 1 1 0 Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25) Plus-3 PF03126.18 ELR22549.1 - 4.7e-30 104.3 0.1 1.1e-29 103.2 0.1 1.6 1 0 0 1 1 1 1 Plus-3 domain Y_phosphatase PF00102.27 ELR22550.1 - 1.4e-61 208.1 0.0 1.6e-60 204.6 0.0 2.1 1 1 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.6 ELR22550.1 - 1.7e-07 31.5 0.1 2.9e-07 30.7 0.1 1.4 1 0 0 1 1 1 1 Tyrosine phosphatase family DSPc PF00782.20 ELR22550.1 - 4.1e-05 23.4 0.0 0.00015 21.6 0.0 1.9 2 0 0 2 2 2 1 Dual specificity phosphatase, catalytic domain DNA_pol_phi PF04931.13 ELR22550.1 - 0.34 9.0 1.1 0.52 8.3 1.1 1.2 1 0 0 1 1 1 0 DNA polymerase phi Pkinase PF00069.25 ELR22551.1 - 1.1e-12 47.9 0.0 1.6e-12 47.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR22551.1 - 4.7e-08 32.6 0.0 6.4e-08 32.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase BLACT_WH PF17778.1 ELR22551.1 - 0.035 14.1 0.1 0.14 12.2 0.1 2.0 1 0 0 1 1 1 0 Beta-lactamase associated winged helix domain Myb_DNA-bind_7 PF15963.5 ELR22552.1 - 0.076 12.9 0.5 0.076 12.9 0.5 2.3 2 0 0 2 2 2 0 Myb DNA-binding like ZnuA PF01297.17 ELR22552.1 - 0.087 12.2 0.6 0.12 11.8 0.6 1.1 1 0 0 1 1 1 0 Zinc-uptake complex component A periplasmic ENTH PF01417.20 ELR22553.1 - 6.5e-09 35.9 0.0 1e-08 35.3 0.0 1.3 1 0 0 1 1 1 1 ENTH domain SelP_N PF04592.14 ELR22553.1 - 4.6 6.6 7.2 7.7 5.9 7.2 1.2 1 0 0 1 1 1 0 Selenoprotein P, N terminal region ATG7_N PF16420.5 ELR22555.1 - 1.7e-57 195.3 0.0 2.6e-57 194.8 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-like modifier-activating enzyme ATG7 N-terminus ThiF PF00899.21 ELR22555.1 - 1.9e-34 119.1 0.0 7.2e-26 91.0 0.0 2.2 2 0 0 2 2 2 2 ThiF family Shikimate_DH PF01488.20 ELR22555.1 - 0.21 11.7 0.0 0.42 10.7 0.0 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Sel1 PF08238.12 ELR22556.1 - 3.7e-45 151.4 55.6 2.2e-07 31.3 0.4 14.0 13 1 0 14 14 14 11 Sel1 repeat Clathrin PF00637.20 ELR22556.1 - 0.2 11.5 1.8 16 5.3 0.1 3.4 3 0 0 3 3 3 0 Region in Clathrin and VPS VHP PF02209.19 ELR22557.1 - 2e-15 56.6 3.8 7.4e-15 54.7 3.8 2.1 1 0 0 1 1 1 1 Villin headpiece domain Myb_DNA-bind_6 PF13921.6 ELR22558.1 - 1.9e-20 72.8 5.1 1.1e-07 31.9 1.3 3.8 2 1 1 3 3 3 3 Myb-like DNA-binding domain Myb_DNA-binding PF00249.31 ELR22558.1 - 5.6e-19 68.1 8.1 8.9e-08 32.2 0.2 3.8 4 0 0 4 4 4 3 Myb-like DNA-binding domain DEAD PF00270.29 ELR22559.1 - 2.4e-50 170.7 0.0 4.5e-50 169.8 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ELR22559.1 - 2.4e-30 105.1 0.0 1.4e-29 102.7 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 ELR22559.1 - 0.011 15.7 0.0 0.021 14.8 0.0 1.4 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit AAA_19 PF13245.6 ELR22559.1 - 0.036 14.4 0.0 12 6.2 0.0 2.4 2 0 0 2 2 2 0 AAA domain Metallophos PF00149.28 ELR22560.1 - 9.3e-36 124.3 0.7 1.4e-35 123.6 0.7 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 ELR22560.1 - 0.0045 17.4 0.0 0.0093 16.4 0.0 1.5 1 0 0 1 1 1 1 Serine-threonine protein phosphatase N-terminal domain Metallophos_2 PF12850.7 ELR22560.1 - 0.12 12.5 0.0 0.2 11.9 0.0 1.3 1 0 0 1 1 1 0 Calcineurin-like phosphoesterase superfamily domain Methyltransf_10 PF05971.12 ELR22561.1 - 4.5e-74 249.5 0.1 3.2e-72 243.4 0.0 2.8 2 1 0 2 2 2 1 RNA methyltransferase MTS PF05175.14 ELR22561.1 - 1.2e-05 24.9 0.0 2.3e-05 24.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain PrmA PF06325.13 ELR22561.1 - 3.2e-05 23.5 0.0 5.4e-05 22.7 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_12 PF08242.12 ELR22561.1 - 0.0086 16.8 0.0 0.021 15.6 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.7 ELR22561.1 - 0.012 15.5 0.0 0.036 14.0 0.0 1.6 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_25 PF13649.6 ELR22561.1 - 0.064 14.0 0.0 0.16 12.7 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain RhoGAP PF00620.27 ELR22562.1 - 5.2e-18 65.3 0.0 1.1e-17 64.3 0.0 1.5 1 1 0 1 1 1 1 RhoGAP domain RRM_1 PF00076.22 ELR22563.1 - 1.1e-21 76.4 0.3 1.1e-15 57.2 0.1 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 ELR22563.1 - 1.3e-05 24.8 0.0 8e-05 22.2 0.0 2.0 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 ELR22563.1 - 0.023 14.5 0.0 0.043 13.7 0.0 1.4 1 0 0 1 1 1 0 Occluded RNA-recognition motif zf-C2H2 PF00096.26 ELR22564.1 - 0.0017 18.7 4.9 0.43 11.1 0.1 2.3 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 ELR22564.1 - 0.012 16.4 6.2 1.8 9.6 0.1 2.4 2 0 0 2 2 2 0 C2H2-type zinc finger PyrI_C PF02748.15 ELR22564.1 - 0.5 10.3 5.5 7.1 6.6 0.4 2.2 1 1 1 2 2 2 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-FCS PF06467.14 ELR22564.1 - 4.3 7.4 5.6 21 5.2 1.6 2.4 1 1 1 2 2 2 0 MYM-type Zinc finger with FCS sequence motif COPIIcoated_ERV PF07970.12 ELR22565.1 - 1.3e-41 142.9 0.1 1.7e-41 142.5 0.1 1.2 1 0 0 1 1 1 1 Endoplasmic reticulum vesicle transporter ERGIC_N PF13850.6 ELR22565.1 - 3e-21 75.6 0.0 5.1e-21 74.8 0.0 1.4 1 0 0 1 1 1 1 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) CTV_P33 PF07184.11 ELR22565.1 - 0.023 13.8 0.0 0.036 13.1 0.0 1.2 1 0 0 1 1 1 0 Citrus tristeza virus P33 protein Pinin_SDK_memA PF04696.13 ELR22566.1 - 1e-18 67.7 9.9 1e-18 67.7 9.9 4.4 4 1 0 4 4 4 1 pinin/SDK/memA/ protein conserved region Seryl_tRNA_N PF02403.22 ELR22566.1 - 0.83 9.9 14.1 6.2 7.1 10.8 2.6 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain Cytadhesin_P30 PF07271.11 ELR22566.1 - 1.5 8.3 6.1 2.6 7.6 6.1 1.3 1 0 0 1 1 1 0 Cytadhesin P30/P32 Peptidase_S24 PF00717.23 ELR22567.1 - 2.7e-10 40.1 0.1 4e-10 39.5 0.1 1.3 1 0 0 1 1 1 1 Peptidase S24-like Methyltransf_12 PF08242.12 ELR22568.1 - 5e-17 62.5 0.0 9.1e-17 61.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ELR22568.1 - 1.6e-16 60.8 0.0 3e-16 59.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 ELR22568.1 - 9.9e-15 54.8 0.0 1.3e-14 54.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ELR22568.1 - 7.7e-14 52.1 0.0 1.3e-13 51.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ELR22568.1 - 3.7e-12 46.3 0.0 5e-12 45.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 ELR22568.1 - 6.7e-05 22.3 0.0 0.0001 21.7 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family MTS PF05175.14 ELR22568.1 - 0.00027 20.5 0.0 0.00043 19.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_4 PF02390.17 ELR22568.1 - 0.00085 18.8 0.0 0.027 14.0 0.0 2.4 3 0 0 3 3 3 1 Putative methyltransferase Methyltransf_8 PF05148.15 ELR22568.1 - 0.0017 18.2 0.3 0.01 15.7 0.3 2.0 1 1 0 1 1 1 1 Hypothetical methyltransferase Methyltransf_33 PF10017.9 ELR22568.1 - 0.013 14.7 0.0 0.019 14.1 0.0 1.2 1 0 0 1 1 1 0 Histidine-specific methyltransferase, SAM-dependent NNMT_PNMT_TEMT PF01234.17 ELR22568.1 - 0.038 13.2 0.0 0.11 11.6 0.0 1.7 2 0 0 2 2 2 0 NNMT/PNMT/TEMT family LCM PF04072.14 ELR22568.1 - 0.042 13.8 0.0 0.069 13.1 0.0 1.4 1 0 0 1 1 1 0 Leucine carboxyl methyltransferase Met_10 PF02475.16 ELR22568.1 - 0.063 13.0 0.0 0.098 12.4 0.0 1.3 1 0 0 1 1 1 0 Met-10+ like-protein DOT1 PF08123.13 ELR22568.1 - 0.12 11.9 0.0 0.24 10.9 0.0 1.5 1 0 0 1 1 1 0 Histone methylation protein DOT1 Methyltransf_24 PF13578.6 ELR22568.1 - 0.15 13.1 0.0 0.29 12.2 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Gly_rich PF12810.7 ELR22570.1 - 0.00084 19.3 1.8 0.0016 18.4 1.8 1.4 1 0 0 1 1 1 1 Glycine rich protein SUIM_assoc PF16619.5 ELR22570.1 - 0.006 16.6 8.0 0.006 16.6 8.0 4.6 4 0 0 4 4 4 2 Unstructured region C-term to UIM in Ataxin3 Shugoshin_N PF07558.11 ELR22571.1 - 0.00093 19.0 7.8 0.14 12.1 0.5 3.4 4 0 0 4 4 3 2 Shugoshin N-terminal coiled-coil region SlyX PF04102.12 ELR22571.1 - 0.004 17.7 17.4 0.18 12.5 0.9 4.5 2 1 2 4 4 4 2 SlyX Exonuc_VII_L PF02601.15 ELR22571.1 - 0.006 16.2 9.5 0.006 16.2 9.5 1.6 2 0 0 2 2 2 1 Exonuclease VII, large subunit Ax_dynein_light PF10211.9 ELR22571.1 - 0.042 13.8 22.8 0.074 13.0 11.3 2.8 2 1 1 3 3 3 0 Axonemal dynein light chain Cluap1 PF10234.9 ELR22571.1 - 0.075 12.4 15.4 0.096 12.1 15.0 1.3 1 1 0 1 1 1 0 Clusterin-associated protein-1 Syntaxin-6_N PF09177.11 ELR22571.1 - 0.081 13.5 10.8 0.6 10.7 4.7 2.7 2 1 0 2 2 2 0 Syntaxin 6, N-terminal YnfE PF17452.2 ELR22571.1 - 0.17 12.2 3.1 2.4 8.5 0.2 3.1 3 0 0 3 3 3 0 Uncharacterized YnfE-like ATG16 PF08614.11 ELR22571.1 - 0.18 12.0 30.5 0.054 13.7 26.2 2.1 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) CENP-H PF05837.12 ELR22571.1 - 0.43 11.0 27.6 0.64 10.4 4.7 3.1 2 1 1 3 3 3 0 Centromere protein H (CENP-H) AIP3 PF03915.13 ELR22571.1 - 0.48 9.5 14.6 0.61 9.1 14.6 1.1 1 0 0 1 1 1 0 Actin interacting protein 3 YabA PF06156.13 ELR22571.1 - 0.51 11.0 20.6 0.34 11.6 1.5 3.2 2 1 1 3 3 3 0 Initiation control protein YabA DUF4618 PF15397.6 ELR22571.1 - 0.71 9.2 12.9 0.73 9.2 7.2 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4618) AAA_13 PF13166.6 ELR22571.1 - 0.86 8.2 14.1 1.3 7.6 14.1 1.4 1 0 0 1 1 1 0 AAA domain Taxilin PF09728.9 ELR22571.1 - 0.87 8.7 22.9 0.17 11.0 16.6 2.0 2 0 0 2 2 2 0 Myosin-like coiled-coil protein DUF4407 PF14362.6 ELR22571.1 - 0.91 8.8 24.1 2.6 7.3 17.8 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) DUF3439 PF11921.8 ELR22571.1 - 1 9.3 7.9 0.23 11.4 1.3 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3439) Allexi_40kDa PF05549.11 ELR22571.1 - 1.2 8.5 11.5 0.39 10.2 2.7 2.3 1 1 0 2 2 2 0 Allexivirus 40kDa protein Fib_alpha PF08702.10 ELR22571.1 - 1.3 9.2 12.9 1.7 8.8 1.6 3.0 1 1 1 3 3 3 0 Fibrinogen alpha/beta chain family FemAB PF02388.16 ELR22571.1 - 1.5 7.7 14.9 0.029 13.2 5.8 2.1 1 1 0 2 2 2 0 FemAB family YkyA PF10368.9 ELR22571.1 - 2.3 7.9 20.5 0.18 11.5 13.3 2.0 2 0 0 2 2 2 0 Putative cell-wall binding lipoprotein TSC22 PF01166.18 ELR22571.1 - 3.2 8.1 12.7 4.2 7.8 3.2 3.8 2 1 2 4 4 4 0 TSC-22/dip/bun family DUF948 PF06103.11 ELR22571.1 - 3.8 7.8 13.9 0.081 13.2 1.5 3.0 3 1 1 4 4 3 0 Bacterial protein of unknown function (DUF948) Myb_DNA-bind_4 PF13837.6 ELR22571.1 - 4.2 7.8 9.9 5.4 7.5 4.4 2.9 2 1 0 2 2 2 0 Myb/SANT-like DNA-binding domain Cep57_MT_bd PF06657.13 ELR22571.1 - 4.3 7.8 12.2 1.3 9.5 6.6 2.4 2 0 0 2 2 2 0 Centrosome microtubule-binding domain of Cep57 Spc24 PF08286.11 ELR22571.1 - 5.1 7.4 18.5 2.2 8.5 5.9 3.1 2 1 1 3 3 3 0 Spc24 subunit of Ndc80 DUF3810 PF12725.7 ELR22571.1 - 5.2 6.3 6.3 6.7 6.0 5.7 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3810) PRKG1_interact PF15898.5 ELR22571.1 - 5.3 8.0 23.0 4.6 8.2 5.0 2.6 1 1 1 2 2 2 0 cGMP-dependent protein kinase interacting domain FlaC_arch PF05377.11 ELR22571.1 - 5.5 7.5 13.5 3.8 8.0 0.3 3.8 2 1 2 4 4 4 0 Flagella accessory protein C (FlaC) Cnn_1N PF07989.11 ELR22571.1 - 5.9 7.1 18.9 2.3 8.4 0.3 3.4 2 1 1 3 3 3 0 Centrosomin N-terminal motif 1 TMF_DNA_bd PF12329.8 ELR22571.1 - 9.3 6.3 29.0 9.6 6.3 1.1 3.9 2 1 1 3 3 3 0 TATA element modulatory factor 1 DNA binding bZIP_1 PF00170.21 ELR22571.1 - 9.4 6.4 21.5 0.63 10.2 0.5 3.9 2 1 2 4 4 4 0 bZIP transcription factor PspB PF06667.12 ELR22571.1 - 9.5 6.4 7.1 49 4.1 2.2 2.9 2 1 1 3 3 3 0 Phage shock protein B B12D PF06522.11 ELR22572.1 - 0.071 12.9 0.0 0.14 12.0 0.0 1.4 1 0 0 1 1 1 0 NADH-ubiquinone reductase complex 1 MLRQ subunit Ribosomal_L13 PF00572.18 ELR22573.1 - 2.6e-08 34.2 0.1 3.2e-06 27.4 0.0 2.6 2 1 0 2 2 2 1 Ribosomal protein L13 CytochromB561_N PF09786.9 ELR22574.1 - 1.8 7.5 11.9 2.6 6.9 11.9 1.2 1 0 0 1 1 1 0 Cytochrome B561, N terminal Apt1 PF10351.9 ELR22574.1 - 2.4 6.9 5.1 3.1 6.5 5.1 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain SPX PF03105.19 ELR22574.1 - 3.8 7.3 8.3 4.9 7.0 8.3 1.1 1 0 0 1 1 1 0 SPX domain Phenol_monoox PF04663.12 ELR22576.1 - 0.08 13.1 0.0 0.17 12.0 0.0 1.5 1 0 0 1 1 1 0 Phenol hydroxylase conserved region MIT_LIKE_ACTX PF17556.2 ELR22576.1 - 4.4 8.0 13.0 0.14 12.7 2.4 2.5 2 0 0 2 2 2 0 MIT-like atracotoxin family tRNA-synt_2b PF00587.25 ELR22577.1 - 1.2e-35 123.1 0.0 2e-35 122.4 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.20 ELR22577.1 - 1e-23 83.2 1.6 2.3e-23 82.2 0.8 2.0 2 0 0 2 2 2 1 Anticodon binding domain TGS PF02824.21 ELR22577.1 - 1.2e-13 50.9 0.0 2.1e-13 50.1 0.0 1.4 1 0 0 1 1 1 1 TGS domain tRNA_SAD PF07973.14 ELR22577.1 - 9.6e-11 41.6 0.0 1.9e-10 40.7 0.0 1.5 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain UvsW PF11637.8 ELR22577.1 - 0.095 12.8 0.4 5.2 7.2 0.0 2.8 3 0 0 3 3 3 0 ATP-dependant DNA helicase UvsW Methyltransf_16 PF10294.9 ELR22578.1 - 3.8e-30 104.9 0.1 5.6e-30 104.4 0.1 1.2 1 0 0 1 1 1 1 Lysine methyltransferase PrmA PF06325.13 ELR22578.1 - 0.0031 16.9 0.0 0.0053 16.2 0.0 1.4 1 1 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_23 PF13489.6 ELR22578.1 - 0.0051 16.7 0.0 0.0092 15.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Chromo PF00385.24 ELR22581.1 - 0.0001 22.1 0.0 0.0001 22.1 0.0 2.3 2 0 0 2 2 1 1 Chromo (CHRromatin Organisation MOdifier) domain BUD22 PF09073.10 ELR22581.1 - 0.0096 15.3 13.9 0.012 15.0 13.9 1.1 1 0 0 1 1 1 1 BUD22 NOA36 PF06524.12 ELR22581.1 - 0.052 12.9 12.3 0.068 12.5 12.3 1.1 1 0 0 1 1 1 0 NOA36 protein CDC45 PF02724.14 ELR22581.1 - 0.058 11.7 8.9 0.073 11.4 8.9 1.2 1 0 0 1 1 1 0 CDC45-like protein BAF1_ABF1 PF04684.13 ELR22581.1 - 0.075 12.1 8.2 0.096 11.7 8.2 1.0 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor RRN3 PF05327.11 ELR22581.1 - 0.12 10.9 5.9 0.14 10.7 5.9 1.2 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Thymopoietin PF08198.11 ELR22581.1 - 0.12 12.0 0.0 0.96 9.1 0.0 2.3 2 0 0 2 2 2 0 Thymopoietin protein Adeno_terminal PF02459.15 ELR22581.1 - 0.19 10.1 3.8 0.21 9.9 3.8 1.2 1 0 0 1 1 1 0 Adenoviral DNA terminal protein PPP4R2 PF09184.11 ELR22581.1 - 0.29 10.7 18.5 0.42 10.1 18.5 1.2 1 0 0 1 1 1 0 PPP4R2 DNA_pol_phi PF04931.13 ELR22581.1 - 0.41 8.7 19.4 0.56 8.2 19.4 1.2 1 0 0 1 1 1 0 DNA polymerase phi Nop14 PF04147.12 ELR22581.1 - 0.47 8.6 21.9 0.61 8.2 21.9 1.1 1 0 0 1 1 1 0 Nop14-like family Tub_N PF16322.5 ELR22581.1 - 0.76 10.1 17.3 1.1 9.7 17.3 1.1 1 0 0 1 1 1 0 Tubby N-terminal SKA1 PF07160.12 ELR22581.1 - 1.6 8.5 14.9 2.2 8.1 14.3 1.4 1 1 0 1 1 1 0 Spindle and kinetochore-associated protein 1 SDA1 PF05285.12 ELR22581.1 - 2.5 7.5 23.9 3.5 7.0 23.9 1.1 1 0 0 1 1 1 0 SDA1 CDC27 PF09507.10 ELR22581.1 - 3.3 7.0 20.3 4.3 6.6 20.3 1.1 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Paf1 PF03985.13 ELR22581.1 - 3.9 6.4 20.9 5.8 5.8 20.9 1.2 1 0 0 1 1 1 0 Paf1 Nucleo_P87 PF07267.11 ELR22581.1 - 3.9 6.2 11.8 5.4 5.7 11.8 1.2 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 MscS_TM PF12794.7 ELR22581.1 - 4.9 5.9 6.5 9.5 5.0 6.5 1.4 1 0 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 V_ATPase_I PF01496.19 ELR22581.1 - 5 4.9 8.1 7.2 4.4 8.1 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Cwf_Cwc_15 PF04889.12 ELR22581.1 - 5.4 6.7 21.0 9.8 5.8 21.0 1.4 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein MDM10 PF12519.8 ELR22581.1 - 8.7 5.1 8.0 12 4.7 8.0 1.1 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 Pkinase_Tyr PF07714.17 ELR22582.1 - 5.6e-64 215.9 0.0 8.7e-64 215.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ELR22582.1 - 5.7e-33 114.4 0.0 9.8e-33 113.6 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain RCC1 PF00415.18 ELR22582.1 - 2.6e-18 66.4 3.7 1.7e-05 25.3 0.0 5.9 5 2 0 5 5 5 4 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 ELR22582.1 - 1.7e-15 56.3 0.3 0.0023 17.7 0.0 4.6 4 0 0 4 4 4 3 Regulator of chromosome condensation (RCC1) repeat Kdo PF06293.14 ELR22582.1 - 0.0011 18.4 0.0 0.0022 17.4 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 ELR22582.1 - 0.068 13.1 0.0 0.13 12.2 0.0 1.5 1 0 0 1 1 1 0 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 ELR22582.1 - 0.47 9.2 4.6 0.59 8.8 0.1 2.2 2 0 0 2 2 2 0 Fungal protein kinase Patatin PF01734.22 ELR22583.1 - 2.7e-14 53.8 0.0 8.3e-14 52.2 0.0 1.9 1 0 0 1 1 1 1 Patatin-like phospholipase PH PF00169.29 ELR22583.1 - 1.4e-08 35.2 0.7 1.9e-05 25.1 0.0 3.2 3 0 0 3 3 3 2 PH domain PH_11 PF15413.6 ELR22583.1 - 0.12 12.9 1.9 1.5 9.2 0.7 2.8 2 0 0 2 2 2 0 Pleckstrin homology domain Thx PF17070.5 ELR22583.1 - 0.19 11.9 0.9 0.47 10.6 0.9 1.6 1 0 0 1 1 1 0 30S ribosomal protein Thx AF-4 PF05110.13 ELR22583.1 - 0.51 8.4 2.8 1 7.3 2.8 1.4 1 0 0 1 1 1 0 AF-4 proto-oncoprotein Sel1 PF08238.12 ELR22584.1 - 9.5e-26 89.7 8.8 1.6e-08 34.9 0.3 3.4 3 0 0 3 3 3 3 Sel1 repeat BTB_2 PF02214.22 ELR22584.1 - 4.8e-15 55.7 0.0 9.1e-15 54.8 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain TPR_16 PF13432.6 ELR22584.1 - 0.0042 17.7 5.8 0.56 10.9 2.9 3.0 1 1 1 2 2 2 2 Tetratricopeptide repeat Ribosomal_L32e PF01655.18 ELR22584.1 - 0.04 14.4 0.0 0.073 13.5 0.0 1.4 1 0 0 1 1 1 0 Ribosomal protein L32 TPR_6 PF13174.6 ELR22584.1 - 0.053 14.2 6.9 21 6.0 0.1 4.0 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_12 PF13424.6 ELR22584.1 - 0.083 13.2 1.5 3 8.2 0.1 3.2 2 1 0 2 2 2 0 Tetratricopeptide repeat BSD PF03909.17 ELR22585.1 - 2.9e-14 52.8 0.5 6.7e-14 51.6 0.5 1.7 1 0 0 1 1 1 1 BSD domain RB_A PF01858.17 ELR22585.1 - 2.2 8.1 8.5 2.2 8.1 0.1 2.5 3 0 0 3 3 3 0 Retinoblastoma-associated protein A domain DUF1279 PF06916.13 ELR22586.1 - 2.7e-05 24.6 0.1 4.7e-05 23.9 0.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1279) TehB PF03848.14 ELR22587.1 - 6.8e-09 35.4 0.0 1e-08 34.8 0.0 1.2 1 0 0 1 1 1 1 Tellurite resistance protein TehB Methyltransf_25 PF13649.6 ELR22587.1 - 7.5e-09 36.2 0.0 1.2e-08 35.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 ELR22587.1 - 1.5e-08 34.7 0.0 2.5e-08 33.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ELR22587.1 - 1.3e-07 32.3 0.0 2.8e-07 31.2 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ELR22587.1 - 1.9e-07 31.7 0.1 6.2e-07 30.0 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 ELR22587.1 - 2.8e-07 30.4 0.0 8.1e-07 29.0 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain TPMT PF05724.11 ELR22587.1 - 0.00019 21.2 0.0 0.00028 20.6 0.0 1.2 1 0 0 1 1 1 1 Thiopurine S-methyltransferase (TPMT) DUF938 PF06080.12 ELR22587.1 - 0.0011 18.8 0.0 0.0014 18.4 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF938) Methyltransf_15 PF09445.10 ELR22587.1 - 0.0041 16.7 0.0 0.0057 16.2 0.0 1.2 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase Rhodanese PF00581.20 ELR22587.1 - 0.13 12.8 0.0 0.23 12.0 0.0 1.4 1 0 0 1 1 1 0 Rhodanese-like domain CMAS PF02353.20 ELR22587.1 - 0.13 11.5 0.0 0.21 10.9 0.0 1.3 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Cwf_Cwc_15 PF04889.12 ELR22588.1 - 0.031 14.0 6.5 0.043 13.6 6.5 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein RPN2_C PF18004.1 ELR22588.1 - 0.051 13.5 3.4 0.092 12.7 3.4 1.3 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain NOA36 PF06524.12 ELR22588.1 - 6.2 6.0 6.6 8.7 5.6 6.6 1.1 1 0 0 1 1 1 0 NOA36 protein Bmt2 PF11968.8 ELR22589.1 - 2.1e-50 171.6 0.2 2.6e-29 102.7 0.2 2.1 2 0 0 2 2 2 2 25S rRNA (adenine(2142)-N(1))-methyltransferase, Bmt2 Methyltransf_8 PF05148.15 ELR22589.1 - 0.0052 16.7 0.1 0.012 15.4 0.1 1.6 2 0 0 2 2 2 1 Hypothetical methyltransferase HlyIII PF03006.20 ELR22590.1 - 2.4e-57 194.2 19.9 2.9e-57 194.0 19.9 1.0 1 0 0 1 1 1 1 Haemolysin-III related ELO PF01151.18 ELR22592.1 - 2.3e-60 204.2 10.5 2.9e-60 203.9 10.5 1.0 1 0 0 1 1 1 1 GNS1/SUR4 family HUN PF08729.10 ELR22593.1 - 4.5e-08 33.0 4.8 4.5e-08 33.0 4.8 2.6 2 0 0 2 2 2 1 HPC2 and ubinuclein domain UBN_AB PF14075.6 ELR22593.1 - 4.5e-06 26.5 0.8 4.5e-06 26.5 0.8 5.7 4 2 1 5 5 5 2 Ubinuclein conserved middle domain ADP_ribosyl_GH PF03747.14 ELR22593.1 - 0.28 10.9 0.0 0.28 10.9 0.0 2.1 2 0 0 2 2 2 0 ADP-ribosylglycohydrolase Draxin PF15550.6 ELR22593.1 - 0.45 10.3 25.1 0.37 10.6 13.6 2.6 2 0 0 2 2 2 0 Draxin Dsh_C PF12316.8 ELR22593.1 - 3.5 8.0 34.7 2.6 8.4 17.2 2.4 2 0 0 2 2 2 0 Segment polarity protein dishevelled (Dsh) C terminal Rrn6 PF10214.9 ELR22593.1 - 4.8 5.5 24.7 1.5 7.2 12.3 2.6 2 0 0 2 2 2 0 RNA polymerase I-specific transcription-initiation factor Phage_lysis PF03245.13 ELR22594.1 - 0.00016 21.8 6.1 0.00016 21.8 6.1 6.8 5 4 0 6 6 6 1 Bacteriophage Rz lysis protein DMPK_coil PF08826.10 ELR22594.1 - 0.0049 17.0 3.6 0.0049 17.0 3.6 8.7 9 2 1 10 10 10 1 DMPK coiled coil domain like DUF3138 PF11336.8 ELR22594.1 - 0.86 8.1 4.2 4.5 5.8 0.0 3.3 2 1 2 4 4 4 0 Protein of unknown function (DUF3138) AAA_13 PF13166.6 ELR22594.1 - 3.2 6.3 74.9 0.073 11.7 11.6 4.2 2 1 2 4 4 4 0 AAA domain DUF4588 PF15251.6 ELR22595.1 - 0.0045 16.8 1.4 0.025 14.3 0.0 2.2 2 1 0 2 2 2 1 Domain of unknown function (DUF4588) DUF4719 PF15843.5 ELR22595.1 - 0.01 16.0 0.6 0.023 14.8 0.6 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4719) E7 PF00527.18 ELR22595.1 - 2.2 8.5 4.0 2.3 8.4 0.4 2.2 2 0 0 2 2 2 0 E7 protein, Early protein EAP30 PF04157.16 ELR22596.1 - 0.055 12.7 0.1 0.071 12.4 0.1 1.1 1 0 0 1 1 1 0 EAP30/Vps36 family Pkinase PF00069.25 ELR22597.1 - 5.6e-50 170.1 3.0 1.9e-24 86.5 1.6 3.1 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ELR22597.1 - 5.5e-22 78.3 1.1 1.4e-13 50.7 0.3 3.0 1 1 1 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 ELR22597.1 - 0.017 14.5 0.3 1.1 8.5 0.0 2.2 2 0 0 2 2 2 0 Kinase-like DUF1084 PF06454.11 ELR22598.1 - 3.5e-12 46.3 21.4 8.9e-12 45.0 21.4 1.5 1 1 0 1 1 1 1 Protein of unknown function (DUF1084) DUF4149 PF13664.6 ELR22598.1 - 2.9 8.2 13.0 1.2 9.4 0.9 3.6 1 1 2 3 3 3 0 Domain of unknown function (DUF4149) GTP_EFTU PF00009.27 ELR22599.1 - 1.1e-35 122.9 0.0 1.8e-35 122.3 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain F-box-like PF12937.7 ELR22599.1 - 7.8e-09 35.3 0.2 1.4e-08 34.5 0.2 1.4 1 0 0 1 1 1 1 F-box-like MMR_HSR1 PF01926.23 ELR22599.1 - 8e-07 29.1 0.0 0.0012 18.9 0.0 2.5 2 0 0 2 2 2 2 50S ribosome-binding GTPase Roc PF08477.13 ELR22599.1 - 0.00021 21.5 0.1 0.046 13.9 0.0 3.2 3 0 0 3 3 3 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 ELR22599.1 - 0.0067 15.9 0.0 0.87 9.0 0.0 2.2 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit FeoB_N PF02421.18 ELR22599.1 - 0.0086 15.6 0.0 0.41 10.2 0.0 2.9 2 1 0 2 2 2 1 Ferrous iron transport protein B GTP_EFTU_D3 PF03143.17 ELR22599.1 - 0.035 14.4 0.0 0.068 13.5 0.0 1.5 1 0 0 1 1 1 0 Elongation factor Tu C-terminal domain F-box PF00646.33 ELR22599.1 - 0.05 13.5 0.0 0.099 12.6 0.0 1.5 1 0 0 1 1 1 0 F-box domain Ras PF00071.22 ELR22599.1 - 0.12 12.0 0.1 2.3 7.8 0.0 2.6 2 1 0 2 2 2 0 Ras family Gtr1_RagA PF04670.12 ELR22599.1 - 0.14 11.5 0.0 1.9 7.8 0.0 2.3 1 1 0 1 1 1 0 Gtr1/RagA G protein conserved region Ank_4 PF13637.6 ELR22601.1 - 1.1e-24 86.5 1.8 3.6e-12 46.6 0.1 3.9 1 1 3 4 4 4 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 ELR22601.1 - 3.1e-24 85.4 0.2 2.9e-16 59.8 0.1 2.2 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 ELR22601.1 - 4.4e-15 55.6 0.1 5e-07 29.9 0.0 3.1 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.30 ELR22601.1 - 1e-14 54.2 0.0 5.6e-06 26.6 0.0 4.1 4 0 0 4 4 4 2 Ankyrin repeat Ank_3 PF13606.6 ELR22601.1 - 1.1e-12 46.9 0.0 0.00011 22.4 0.0 3.7 4 0 0 4 4 4 2 Ankyrin repeat CCDC84 PF14968.6 ELR22601.1 - 0.0064 16.2 0.5 0.0097 15.6 0.5 1.2 1 0 0 1 1 1 1 Coiled coil protein 84 PYRIN PF02758.16 ELR22601.1 - 0.099 12.8 0.3 0.22 11.7 0.1 1.6 2 0 0 2 2 2 0 PAAD/DAPIN/Pyrin domain DBD_Tnp_Hermes PF10683.9 ELR22601.1 - 0.12 12.0 0.0 0.24 11.1 0.0 1.4 1 0 0 1 1 1 0 Hermes transposase DNA-binding domain 2OG-FeII_Oxy_3 PF13640.6 ELR22602.1 - 1e-05 26.3 0.0 1.6e-05 25.7 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily HATPase_c PF02518.26 ELR22603.1 - 2.5e-46 156.8 0.0 2.6e-22 79.4 0.0 2.6 2 0 0 2 2 2 2 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 ELR22603.1 - 1.2e-37 128.5 0.0 7.4e-23 80.9 0.0 2.6 2 0 0 2 2 2 2 Response regulator receiver domain HisKA PF00512.25 ELR22603.1 - 7.2e-24 83.6 18.7 1.9e-13 50.2 0.3 4.1 5 0 0 5 5 5 2 His Kinase A (phospho-acceptor) domain PAS_4 PF08448.10 ELR22603.1 - 1.7e-10 41.2 0.0 0.00031 21.0 0.0 3.1 2 1 0 2 2 2 2 PAS fold GAF_2 PF13185.6 ELR22603.1 - 1.3e-05 25.5 0.1 0.0023 18.2 0.0 3.8 3 1 1 4 4 4 1 GAF domain PAS PF00989.25 ELR22603.1 - 3.1e-05 24.0 0.1 8.1e-05 22.6 0.1 1.7 1 0 0 1 1 1 1 PAS fold PAS_9 PF13426.7 ELR22603.1 - 0.0023 18.2 0.0 0.007 16.6 0.0 1.8 1 0 0 1 1 1 1 PAS domain PAS_8 PF13188.7 ELR22603.1 - 0.0055 16.7 0.1 0.02 14.9 0.1 2.0 1 0 0 1 1 1 1 PAS domain HATPase_c_3 PF13589.6 ELR22603.1 - 0.035 13.9 0.0 0.48 10.2 0.0 2.3 2 0 0 2 2 2 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase GAF_3 PF13492.6 ELR22603.1 - 0.051 13.9 0.1 0.71 10.2 0.0 3.0 4 0 0 4 4 4 0 GAF domain Ras PF00071.22 ELR22606.1 - 3.8e-56 189.2 0.0 4.3e-56 189.0 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR22606.1 - 9.6e-24 83.9 0.0 1.3e-23 83.4 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR22606.1 - 6.7e-09 35.4 0.0 1e-08 34.9 0.0 1.3 1 1 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 ELR22606.1 - 0.00038 20.1 0.0 0.00099 18.7 0.0 1.6 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 ELR22606.1 - 0.042 13.8 0.0 0.43 10.5 0.0 2.0 2 0 0 2 2 2 0 RsgA GTPase Frizzled PF01534.17 ELR22607.1 - 6.3e-26 91.2 17.9 8.3e-26 90.8 17.9 1.1 1 0 0 1 1 1 1 Frizzled/Smoothened family membrane region Dicty_CAR PF05462.11 ELR22607.1 - 2.7e-10 39.9 10.2 5.3e-10 38.9 10.2 1.4 1 0 0 1 1 1 1 Slime mold cyclic AMP receptor 7tm_2 PF00002.24 ELR22607.1 - 2.6e-09 36.7 12.8 2.6e-09 36.7 12.8 2.0 3 0 0 3 3 3 1 7 transmembrane receptor (Secretin family) UPF0370 PF13980.6 ELR22607.1 - 1.8 8.7 5.4 0.51 10.4 0.8 2.4 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0370) TRIC PF05197.13 ELR22608.1 - 4.6e-06 26.3 0.6 1e-05 25.2 0.9 1.5 1 1 1 2 2 2 1 TRIC channel DUF4203 PF13886.6 ELR22608.1 - 3.5 7.3 10.3 2 8.0 6.7 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4203) Ribosomal_S13 PF00416.22 ELR22609.1 - 6.8e-54 181.7 2.0 8.2e-54 181.4 2.0 1.1 1 0 0 1 1 1 1 Ribosomal protein S13/S18 FbpA PF05833.11 ELR22609.1 - 0.0063 15.3 0.0 0.0064 15.3 0.0 1.1 1 0 0 1 1 1 1 Fibronectin-binding protein A N-terminus (FbpA) NdhM PF10664.9 ELR22609.1 - 0.051 13.8 0.0 0.082 13.2 0.0 1.4 1 0 0 1 1 1 0 Cyanobacterial and plastid NDH-1 subunit M HHH_6 PF14579.6 ELR22609.1 - 0.069 13.4 0.1 0.17 12.1 0.1 1.8 1 1 0 1 1 1 0 Helix-hairpin-helix motif Ribosomal_S10 PF00338.22 ELR22610.1 - 3.2e-30 104.2 0.4 4.1e-30 103.9 0.4 1.1 1 0 0 1 1 1 1 Ribosomal protein S10p/S20e Pkinase_Tyr PF07714.17 ELR22611.1 - 1.8e-98 328.9 0.0 2.9e-69 233.2 0.0 4.0 4 0 0 4 4 4 4 Protein tyrosine kinase Pkinase PF00069.25 ELR22611.1 - 2.9e-69 233.4 0.0 1.1e-47 162.6 0.0 3.0 2 1 0 2 2 2 2 Protein kinase domain Haspin_kinase PF12330.8 ELR22611.1 - 1.7e-06 27.2 0.2 0.011 14.7 0.2 3.1 3 0 0 3 3 3 2 Haspin like kinase domain Kinase-like PF14531.6 ELR22611.1 - 3.2e-06 26.7 0.0 0.037 13.3 0.0 2.2 2 0 0 2 2 2 2 Kinase-like Kdo PF06293.14 ELR22611.1 - 5.3e-05 22.7 0.5 0.14 11.5 0.0 2.4 2 0 0 2 2 2 2 Lipopolysaccharide kinase (Kdo/WaaP) family E2F_CC-MB PF16421.5 ELR22612.1 - 6.5e-32 109.8 0.0 1.8e-31 108.4 0.0 1.8 1 0 0 1 1 1 1 E2F transcription factor CC-MB domain E2F_TDP PF02319.20 ELR22612.1 - 3.4e-26 91.1 0.0 7.9e-26 89.9 0.0 1.6 1 0 0 1 1 1 1 E2F/DP family winged-helix DNA-binding domain TrmB PF01978.19 ELR22612.1 - 0.027 14.3 0.0 0.056 13.3 0.0 1.5 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB DivIC PF04977.15 ELR22612.1 - 0.028 14.2 1.5 0.028 14.2 1.5 3.0 3 0 0 3 3 3 0 Septum formation initiator ROKNT PF08067.11 ELR22612.1 - 1.2 9.5 4.0 2.9 8.2 4.0 1.6 1 0 0 1 1 1 0 ROKNT (NUC014) domain Roughex PF06020.11 ELR22613.1 - 0.31 10.1 4.2 0.46 9.5 4.2 1.2 1 0 0 1 1 1 0 Drosophila roughex protein HA2 PF04408.23 ELR22614.1 - 7.7e-28 96.9 0.0 7.7e-28 96.9 0.0 4.4 4 0 0 4 4 4 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 ELR22614.1 - 7.8e-21 74.2 2.2 9.7e-20 70.7 0.1 3.1 3 0 0 3 3 2 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 ELR22614.1 - 1.1e-11 45.0 0.0 1.9e-10 41.0 0.0 2.8 3 0 0 3 3 3 1 Helicase conserved C-terminal domain DEAD PF00270.29 ELR22614.1 - 1.4e-07 31.5 0.0 5.1e-07 29.6 0.0 2.0 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 ELR22614.1 - 7.6e-06 26.2 0.0 2.3e-05 24.7 0.0 1.8 1 0 0 1 1 1 1 AAA domain ATPase PF06745.13 ELR22614.1 - 0.00015 21.2 2.2 0.00055 19.4 0.0 2.7 3 0 0 3 3 3 1 KaiC BUD22 PF09073.10 ELR22614.1 - 0.00036 20.0 6.9 0.00036 20.0 6.9 3.6 3 1 0 3 3 3 1 BUD22 AAA_19 PF13245.6 ELR22614.1 - 0.0031 17.9 0.1 0.014 15.7 0.0 2.2 2 0 0 2 2 2 1 AAA domain SR-25 PF10500.9 ELR22614.1 - 0.0041 16.8 4.9 0.0041 16.8 4.9 5.2 5 1 0 5 5 3 1 Nuclear RNA-splicing-associated protein AAA_30 PF13604.6 ELR22614.1 - 0.032 14.0 0.0 0.073 12.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain PhoH PF02562.16 ELR22614.1 - 0.039 13.4 0.1 0.13 11.7 0.0 1.8 2 0 0 2 2 2 0 PhoH-like protein FtsK_SpoIIIE PF01580.18 ELR22614.1 - 0.13 11.6 0.0 2.1 7.7 0.0 2.3 2 0 0 2 2 2 0 FtsK/SpoIIIE family DUF1484 PF07363.11 ELR22616.1 - 0.028 15.4 0.3 0.078 14.0 0.1 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF1484) C2 PF00168.30 ELR22617.1 - 7.1e-16 58.4 0.0 2.9e-15 56.4 0.0 2.1 1 0 0 1 1 1 1 C2 domain Gti1_Pac2 PF09729.9 ELR22617.1 - 5.4 7.1 8.2 12 5.9 8.2 1.6 1 0 0 1 1 1 0 Gti1/Pac2 family Pkinase_Tyr PF07714.17 ELR22619.1 - 3.7e-06 26.4 0.0 4.6e-06 26.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Cwf_Cwc_15 PF04889.12 ELR22619.1 - 0.0023 17.7 1.0 0.0027 17.5 1.0 1.1 1 0 0 1 1 1 1 Cwf15/Cwc15 cell cycle control protein Peptidase_S9 PF00326.21 ELR22620.1 - 2.2e-06 27.3 0.2 0.062 12.8 0.0 2.3 1 1 1 2 2 2 2 Prolyl oligopeptidase family Abhydrolase_2 PF02230.16 ELR22620.1 - 4.3e-05 23.4 0.0 5.8e-05 23.0 0.0 1.2 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase Hydrolase_4 PF12146.8 ELR22620.1 - 0.00053 19.3 0.3 0.011 15.0 0.0 2.5 1 1 1 2 2 2 1 Serine aminopeptidase, S33 Abhydrolase_3 PF07859.13 ELR22620.1 - 0.0054 16.6 0.0 0.087 12.7 0.0 2.1 1 1 1 2 2 2 1 alpha/beta hydrolase fold Esterase_phd PF10503.9 ELR22620.1 - 0.14 11.6 0.1 0.7 9.3 0.0 1.9 1 1 1 2 2 2 0 Esterase PHB depolymerase Mito_carr PF00153.27 ELR22621.1 - 1.8e-32 111.1 0.2 2.8e-13 49.6 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein YwiC PF14256.6 ELR22621.1 - 0.15 12.4 4.2 1 9.7 0.3 2.5 2 0 0 2 2 2 0 YwiC-like protein Chorein_N PF12624.7 ELR22622.1 - 6.6e-19 68.1 0.0 1.7e-18 66.8 0.0 1.7 1 0 0 1 1 1 1 N-terminal region of Chorein or VPS13 VPS13 PF16908.5 ELR22622.1 - 1.3e-09 38.2 0.0 1.8e-07 31.2 0.0 3.5 2 2 0 2 2 2 1 Vacuolar sorting-associated protein 13, N-terminal VPS13_mid_rpt PF16910.5 ELR22622.1 - 0.022 14.2 0.0 0.065 12.7 0.0 1.8 2 0 0 2 2 2 0 Repeating coiled region of VPS13 LRRC37 PF15779.5 ELR22624.1 - 0.012 16.0 0.7 0.012 16.0 0.7 1.9 3 0 0 3 3 3 0 Leucine-rich repeat-containing protein 37 family DUF5315 PF17242.2 ELR22624.1 - 0.11 12.3 0.0 0.19 11.6 0.0 1.3 1 0 0 1 1 1 0 Disordered region of unknown function (DUF5315) SnoaL PF07366.12 ELR22625.1 - 1.6e-12 47.3 0.0 2.4e-12 46.7 0.0 1.2 1 0 0 1 1 1 1 SnoaL-like polyketide cyclase SnoaL_2 PF12680.7 ELR22625.1 - 1.4e-09 38.5 0.1 2.8e-09 37.5 0.1 1.5 1 0 0 1 1 1 1 SnoaL-like domain SnoaL_4 PF13577.6 ELR22625.1 - 9.6e-05 22.5 0.6 0.00016 21.8 0.1 1.7 2 0 0 2 2 2 1 SnoaL-like domain SnoaL_3 PF13474.6 ELR22625.1 - 0.003 17.8 0.0 0.0049 17.1 0.0 1.4 1 0 0 1 1 1 1 SnoaL-like domain Pex14_N PF04695.13 ELR22625.1 - 0.12 13.1 0.1 0.18 12.5 0.1 1.3 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF410 PF04190.13 ELR22628.1 - 1.8e-62 211.5 0.0 2e-62 211.3 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF410) TPR_2 PF07719.17 ELR22628.1 - 0.014 15.5 7.0 0.24 11.6 0.1 4.5 4 1 1 5 5 5 0 Tetratricopeptide repeat TPR_14 PF13428.6 ELR22628.1 - 0.017 15.9 1.7 9.4 7.4 0.2 3.9 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_17 PF13431.6 ELR22628.1 - 0.025 14.9 0.2 5.6 7.6 0.1 3.0 2 0 0 2 2 2 0 Tetratricopeptide repeat RYDR_ITPR PF01365.21 ELR22628.1 - 0.025 14.0 0.0 0.04 13.3 0.0 1.2 1 0 0 1 1 1 0 RIH domain TPR_12 PF13424.6 ELR22628.1 - 0.039 14.3 3.8 1.8 8.9 0.1 3.7 4 0 0 4 4 4 0 Tetratricopeptide repeat TAF1_subA PF14929.6 ELR22628.1 - 0.084 12.3 0.7 0.095 12.1 0.7 1.3 1 1 0 1 1 1 0 TAF RNA Polymerase I subunit A TPR_8 PF13181.6 ELR22628.1 - 0.11 12.8 1.9 5.1 7.6 0.0 4.0 4 1 1 5 5 5 0 Tetratricopeptide repeat Protoglobin PF11563.8 ELR22628.1 - 0.12 12.3 0.0 0.26 11.2 0.0 1.6 1 0 0 1 1 1 0 Protoglobin CLU PF13236.6 ELR22629.1 - 7.5e-61 205.8 0.0 1.2e-60 205.1 0.0 1.3 1 0 0 1 1 1 1 Clustered mitochondria eIF3_p135 PF12807.7 ELR22629.1 - 7.4e-10 39.1 0.4 2.2e-09 37.6 0.4 1.8 1 0 0 1 1 1 1 Translation initiation factor eIF3 subunit 135 Fels1 PF05666.11 ELR22630.1 - 0.069 12.8 0.2 0.069 12.8 0.2 1.7 2 0 0 2 2 2 0 Fels-1 Prophage Protein-like Evr1_Alr PF04777.13 ELR22631.1 - 3.8e-29 101.1 0.1 7.4e-29 100.2 0.1 1.5 1 0 0 1 1 1 1 Erv1 / Alr family RQC PF09382.10 ELR22632.1 - 3.8e-23 81.5 0.0 7.8e-23 80.4 0.0 1.5 1 0 0 1 1 1 1 RQC domain Helicase_C PF00271.31 ELR22632.1 - 1.5e-17 63.9 0.0 3.7e-17 62.7 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain HTH_40 PF14493.6 ELR22632.1 - 3.4e-15 56.2 0.0 8.1e-15 55.1 0.0 1.7 1 0 0 1 1 1 1 Helix-turn-helix domain KHA PF11834.8 ELR22632.1 - 2.2e-13 50.0 0.1 8.8e-13 48.1 0.0 2.2 2 0 0 2 2 2 1 KHA, dimerisation domain of potassium ion channel DEAD PF00270.29 ELR22632.1 - 4.3e-09 36.4 0.0 0.0018 18.0 0.0 3.0 3 0 0 3 3 3 2 DEAD/DEAH box helicase HRDC PF00570.23 ELR22632.1 - 1.1e-07 31.7 0.0 2.9e-07 30.4 0.0 1.7 1 0 0 1 1 1 1 HRDC domain RecQ_Zn_bind PF16124.5 ELR22632.1 - 0.00016 22.4 0.0 0.00064 20.4 0.0 2.0 1 0 0 1 1 1 1 RecQ zinc-binding Sigma70_r4_2 PF08281.12 ELR22632.1 - 0.00052 19.6 0.6 0.0096 15.6 0.0 2.5 2 0 0 2 2 2 1 Sigma-70, region 4 DUF1510 PF07423.11 ELR22632.1 - 0.021 15.0 1.7 0.05 13.8 1.7 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF1510) PI3K_1B_p101 PF10486.9 ELR22632.1 - 1.5 6.5 4.4 2.6 5.7 4.4 1.3 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit DUF3446 PF11928.8 ELR22632.1 - 1.6 9.1 28.9 4.7 7.6 12.4 3.9 3 0 0 3 3 3 0 Early growth response N-terminal domain GREB1 PF15782.5 ELR22632.1 - 6.4 3.8 5.9 12 2.9 5.9 1.3 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer SH3_2 PF07653.17 ELR22633.1 - 6.8e-16 57.7 0.1 1.4e-07 31.0 0.0 2.7 2 0 0 2 2 2 2 Variant SH3 domain SH3_9 PF14604.6 ELR22633.1 - 1.7e-14 53.4 1.0 8e-08 32.0 0.2 2.6 2 0 0 2 2 2 2 Variant SH3 domain SH3_1 PF00018.28 ELR22633.1 - 2e-08 33.7 0.1 0.0068 16.0 0.0 2.7 2 0 0 2 2 2 2 SH3 domain zf-CpG_bind_C PF12269.8 ELR22633.1 - 0.004 17.0 5.3 0.004 17.0 5.3 7.1 3 3 3 7 7 7 1 CpG binding protein zinc finger C terminal domain ATG27 PF09451.10 ELR22634.1 - 1.6e-26 93.8 0.0 2e-26 93.4 0.0 1.1 1 0 0 1 1 1 1 Autophagy-related protein 27 Man-6-P_recep PF02157.15 ELR22634.1 - 7.1e-11 41.7 0.1 3e-08 33.1 0.0 2.4 2 1 0 2 2 2 2 Mannose-6-phosphate receptor CIMR PF00878.18 ELR22634.1 - 7.8e-07 29.3 0.3 0.048 13.7 0.2 2.1 2 0 0 2 2 2 2 Cation-independent mannose-6-phosphate receptor repeat ELO PF01151.18 ELR22635.1 - 2.6e-51 174.6 18.2 3.2e-51 174.3 18.2 1.0 1 0 0 1 1 1 1 GNS1/SUR4 family Amastin PF07344.11 ELR22636.1 - 0.067 13.0 13.1 0.24 11.2 13.0 2.1 1 1 0 1 1 1 0 Amastin surface glycoprotein SUR7 PF06687.12 ELR22636.1 - 1.2 8.7 7.6 6 6.4 6.8 2.1 2 0 0 2 2 2 0 SUR7/PalI family Glyco_transf_34 PF05637.12 ELR22638.1 - 7.9e-09 35.6 1.1 2.3e-08 34.1 1.1 1.7 1 1 1 2 2 2 1 galactosyl transferase GMA12/MNN10 family DUF273 PF03314.14 ELR22638.1 - 3.2e-05 23.6 0.0 4.9e-05 23.0 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function, DUF273 DUF4898 PF16239.5 ELR22638.1 - 0.089 12.7 0.1 0.18 11.8 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4898) Mucin PF01456.17 ELR22639.1 - 0.056 13.4 6.6 0.079 13.0 6.6 1.2 1 0 0 1 1 1 0 Mucin-like glycoprotein Dicty_REP PF05086.12 ELR22639.1 - 0.059 11.4 1.4 0.056 11.4 1.4 1.0 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein BRCT_3 PF18428.1 ELR22641.1 - 1.4e-11 44.4 0.0 1e-10 41.6 0.0 2.5 2 0 0 2 2 2 1 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 ELR22641.1 - 1.7e-09 38.0 0.0 1.5e-05 25.4 0.0 3.3 2 0 0 2 2 2 2 BRCT domain, a BRCA1 C-terminus domain BRCT PF00533.26 ELR22641.1 - 1.5e-06 28.5 0.0 0.0087 16.4 0.0 2.9 2 0 0 2 2 2 2 BRCA1 C Terminus (BRCT) domain zf-RanBP PF00641.18 ELR22641.1 - 0.016 14.5 5.5 0.037 13.3 5.5 1.5 1 0 0 1 1 1 0 Zn-finger in Ran binding protein and others Glyco_transf_10 PF00852.19 ELR22642.1 - 2e-38 131.8 0.0 3.6e-38 131.0 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Glyco_tran_10_N PF17039.5 ELR22642.1 - 2e-06 28.2 1.0 2.7e-05 24.6 0.4 2.9 3 1 0 3 3 3 1 Fucosyltransferase, N-terminal Aa_trans PF01490.18 ELR22643.1 - 3.2e-06 26.1 38.5 6.8e-06 25.0 38.5 1.5 1 1 0 1 1 1 1 Transmembrane amino acid transporter protein HCNGP PF07818.13 ELR22644.1 - 6e-21 74.9 0.1 1.4e-20 73.8 0.1 1.6 1 0 0 1 1 1 1 HCNGP-like protein CDC45 PF02724.14 ELR22644.1 - 0.64 8.2 9.1 0.76 8.0 9.1 1.2 1 0 0 1 1 1 0 CDC45-like protein DUF913 PF06025.12 ELR22644.1 - 3.2 6.6 4.5 17 4.2 0.0 2.1 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) DUF1768 PF08719.11 ELR22645.1 - 6.1e-40 137.1 0.0 7.5e-40 136.8 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1768) Phage_30_3 PF08010.11 ELR22645.1 - 0.0058 16.4 0.0 0.011 15.5 0.0 1.6 1 1 0 1 1 1 1 Bacteriophage protein GP30.3 DUF3446 PF11928.8 ELR22645.1 - 0.21 11.9 10.7 0.36 11.2 10.7 1.3 1 0 0 1 1 1 0 Early growth response N-terminal domain LRR_4 PF12799.7 ELR22646.1 - 7.4e-15 54.8 25.0 0.029 14.8 0.7 10.1 10 2 0 11 11 11 5 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 ELR22646.1 - 2.9e-07 30.0 30.8 0.032 14.3 0.0 13.0 15 0 0 15 15 15 2 Leucine Rich repeat LRR_8 PF13855.6 ELR22646.1 - 3.6e-07 29.8 18.8 0.00027 20.6 0.3 7.9 7 1 1 8 8 8 3 Leucine rich repeat WWE PF02825.20 ELR22646.1 - 1.7e-05 25.3 0.2 3.5e-05 24.3 0.2 1.5 1 0 0 1 1 1 1 WWE domain LRR_1 PF00560.33 ELR22646.1 - 1.6 9.5 36.5 1e+02 4.0 0.1 13.2 16 1 0 16 16 16 0 Leucine Rich Repeat 2_5_RNA_ligase2 PF13563.6 ELR22647.1 - 2.8e-14 53.3 0.0 4.7e-14 52.6 0.0 1.3 1 0 0 1 1 1 1 2'-5' RNA ligase superfamily RRM_1 PF00076.22 ELR22647.1 - 1e-06 28.4 0.0 1.7e-06 27.7 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-C2H2_4 PF13894.6 ELR22648.1 - 5.9e-08 32.9 38.7 0.013 16.3 0.5 5.6 5 0 0 5 5 5 4 C2H2-type zinc finger zf-C2H2_6 PF13912.6 ELR22648.1 - 6.1e-06 26.1 1.0 6.1e-06 26.1 1.0 4.8 4 0 0 4 4 4 1 C2H2-type zinc finger zf-C2H2 PF00096.26 ELR22648.1 - 0.00041 20.6 40.7 0.11 13.0 1.0 5.0 5 0 0 5 5 5 4 Zinc finger, C2H2 type zf-C2H2_jaz PF12171.8 ELR22648.1 - 0.00086 19.5 18.6 0.0012 19.0 0.5 3.6 3 0 0 3 3 3 2 Zinc-finger double-stranded RNA-binding zf-C2H2_8 PF15909.5 ELR22648.1 - 0.012 15.9 14.6 0.45 10.8 2.6 2.8 2 1 0 2 2 2 0 C2H2-type zinc ribbon zf-RING_7 PF02591.15 ELR22648.1 - 0.074 13.3 1.0 1.8 8.8 0.0 2.9 2 0 0 2 2 2 0 C4-type zinc ribbon domain zinc_ribbon_15 PF17032.5 ELR22648.1 - 0.19 12.5 10.5 1.5 9.6 1.3 2.6 2 0 0 2 2 2 0 zinc-ribbon family zf_UBZ PF18439.1 ELR22648.1 - 0.68 9.6 14.3 6.8 6.4 0.5 4.0 4 0 0 4 4 4 0 Ubiquitin-Binding Zinc Finger zinc_ribbon_5 PF13719.6 ELR22648.1 - 0.75 9.6 8.0 0.76 9.6 0.1 3.5 3 0 0 3 3 3 0 zinc-ribbon domain zf-met PF12874.7 ELR22648.1 - 0.78 10.2 17.2 4.6 7.8 0.9 3.7 3 0 0 3 3 3 0 Zinc-finger of C2H2 type zf-H2C2_2 PF13465.6 ELR22648.1 - 1 9.9 0.0 1 9.9 0.0 4.9 5 0 0 5 5 5 0 Zinc-finger double domain zinc_ribbon_4 PF13717.6 ELR22648.1 - 1.7 8.6 9.3 0.64 10.0 3.3 3.2 2 1 0 2 2 2 0 zinc-ribbon domain C1_4 PF07975.12 ELR22648.1 - 5.6 7.3 13.2 4.9 7.5 1.7 3.0 2 1 0 2 2 2 0 TFIIH C1-like domain DNA_RNApol_7kD PF03604.13 ELR22648.1 - 6.5 6.5 8.1 0.95 9.2 0.1 2.9 3 0 0 3 3 3 0 DNA directed RNA polymerase, 7 kDa subunit RhoGEF PF00621.20 ELR22649.1 - 1.2e-38 133.2 0.0 1.8e-38 132.6 0.0 1.3 1 0 0 1 1 1 1 RhoGEF domain IQ PF00612.27 ELR22649.1 - 0.00021 20.8 0.6 0.00059 19.4 0.6 1.8 1 0 0 1 1 1 1 IQ calmodulin-binding motif IQ_SEC7_PH PF16453.5 ELR22649.1 - 0.022 14.7 0.0 0.073 13.0 0.0 1.8 1 0 0 1 1 1 0 PH domain PH PF00169.29 ELR22649.1 - 0.048 14.2 0.0 0.098 13.2 0.0 1.4 1 0 0 1 1 1 0 PH domain PH_6 PF15406.6 ELR22649.1 - 0.048 13.9 0.0 0.11 12.8 0.0 1.5 1 0 0 1 1 1 0 Pleckstrin homology domain FCH PF00611.23 ELR22649.1 - 0.054 13.8 0.1 0.39 11.0 0.0 2.4 2 1 0 2 2 2 0 Fes/CIP4, and EFC/F-BAR homology domain MFMR PF07777.11 ELR22649.1 - 0.1 13.1 0.1 0.33 11.5 0.1 1.8 1 0 0 1 1 1 0 G-box binding protein MFMR Asparaginase PF00710.20 ELR22651.1 - 1.5e-59 200.8 0.0 4.7e-59 199.2 0.0 1.7 2 0 0 2 2 2 1 Asparaginase, N-terminal Asparaginase_C PF17763.1 ELR22651.1 - 3.1e-30 104.7 0.0 5.5e-30 103.9 0.0 1.4 1 0 0 1 1 1 1 Glutaminase/Asparaginase C-terminal domain EGF_2 PF07974.13 ELR22652.1 - 8.3e-26 90.0 145.4 4.2e-05 23.8 7.2 10.6 9 1 1 10 10 10 9 EGF-like domain EGF PF00008.27 ELR22652.1 - 7.2e-16 58.2 105.2 2.8e-06 27.5 4.1 10.0 8 1 1 9 9 9 9 EGF-like domain hEGF PF12661.7 ELR22652.1 - 7.3e-12 45.5 97.1 0.0036 17.9 2.7 10.3 9 1 0 9 9 9 9 Human growth factor-like EGF EGF_alliinase PF04863.13 ELR22652.1 - 0.00014 22.1 7.5 0.00014 22.1 7.5 10.8 4 3 6 10 10 10 4 Alliinase EGF-like domain FNIP_M PF14637.6 ELR22653.1 - 1.5e-19 70.9 0.0 1.4e-16 61.2 0.0 2.1 1 1 1 2 2 2 2 Folliculin-interacting protein middle domain FNIP_C PF14638.6 ELR22654.1 - 6.8e-17 61.7 0.0 2.3e-16 60.0 0.0 1.7 1 1 0 1 1 1 1 Folliculin-interacting protein C-terminus FNIP_N PF14636.6 ELR22654.1 - 0.0023 18.9 0.0 0.0031 18.5 0.0 1.3 1 0 0 1 1 1 1 Folliculin-interacting protein N-terminus Methyltransf_21 PF05050.12 ELR22655.1 - 1.1e-09 38.6 0.0 2.1e-09 37.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase FkbM domain PKcGMP_CC PF16808.5 ELR22655.1 - 0.026 14.4 0.5 0.048 13.5 0.5 1.3 1 0 0 1 1 1 0 Coiled-coil N-terminus of cGMP-dependent protein kinase DUF5402 PF17393.2 ELR22655.1 - 0.19 11.7 0.0 0.44 10.5 0.0 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5402) MORN PF02493.20 ELR22656.1 - 5.5e-45 148.6 61.8 5.6e-10 38.5 1.2 7.2 7 0 0 7 7 7 7 MORN repeat zf-C3HC4_3 PF13920.6 ELR22656.1 - 9.7e-10 38.2 8.6 1.4e-09 37.6 8.6 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 ELR22656.1 - 0.0017 18.2 10.5 0.003 17.4 10.5 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 DUF2039 PF10217.9 ELR22656.1 - 0.0093 16.3 2.0 0.015 15.6 2.0 1.3 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2039) zf-RING_5 PF14634.6 ELR22656.1 - 0.015 15.2 8.6 0.026 14.5 8.6 1.4 1 0 0 1 1 1 0 zinc-RING finger domain Rhodanese_C PF12368.8 ELR22656.1 - 0.058 13.8 4.2 0.12 12.8 4.2 1.4 1 0 0 1 1 1 0 Rhodanase C-terminal TubC_N PF18563.1 ELR22656.1 - 0.17 11.9 1.1 81 3.3 0.0 3.7 4 0 0 4 4 4 0 TubC N-terminal docking domain DUF448 PF04296.13 ELR22656.1 - 0.4 10.6 2.6 1.9 8.4 0.4 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF448) zf-RING_2 PF13639.6 ELR22656.1 - 0.66 10.4 9.9 1.3 9.4 9.9 1.6 1 0 0 1 1 1 0 Ring finger domain NTP_transferase PF00483.23 ELR22657.1 - 1.2e-18 67.6 0.0 1.6e-18 67.2 0.0 1.1 1 0 0 1 1 1 1 Nucleotidyl transferase NTP_transf_3 PF12804.7 ELR22657.1 - 9.9e-13 48.7 0.0 1.7e-12 48.0 0.0 1.4 1 1 0 1 1 1 1 MobA-like NTP transferase domain IspD PF01128.19 ELR22657.1 - 0.024 14.4 0.0 0.047 13.4 0.0 1.5 1 0 0 1 1 1 0 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase HEAT PF02985.22 ELR22658.1 - 0.02 15.1 4.5 12 6.4 0.0 4.3 4 0 0 4 4 4 0 HEAT repeat HEAT_2 PF13646.6 ELR22658.1 - 0.068 13.6 12.7 0.16 12.4 6.0 3.6 3 1 0 3 3 3 0 HEAT repeats Cnd1 PF12717.7 ELR22658.1 - 0.12 12.4 0.0 0.39 10.8 0.0 1.8 2 0 0 2 2 2 0 non-SMC mitotic condensation complex subunit 1 Arm PF00514.23 ELR22658.1 - 0.2 11.7 20.0 8 6.7 0.2 6.1 6 0 0 6 6 6 0 Armadillo/beta-catenin-like repeat LRR_6 PF13516.6 ELR22659.1 - 9.6e-11 40.9 1.2 0.00018 21.3 0.1 3.3 2 0 0 2 2 2 2 Leucine Rich repeat SH2 PF00017.24 ELR22659.1 - 3.3e-09 36.7 0.0 8.1e-05 22.6 0.0 2.7 2 0 0 2 2 2 2 SH2 domain LRR_4 PF12799.7 ELR22659.1 - 0.011 16.1 1.5 0.3 11.6 0.1 3.2 3 0 0 3 3 3 0 Leucine Rich repeats (2 copies) RPN2_C PF18004.1 ELR22659.1 - 0.092 12.7 0.4 0.17 11.8 0.4 1.3 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain Nop14 PF04147.12 ELR22659.1 - 2.8 6.0 4.6 4.2 5.5 4.6 1.1 1 0 0 1 1 1 0 Nop14-like family BUD22 PF09073.10 ELR22659.1 - 4 6.7 7.1 6.6 6.0 4.0 2.0 2 0 0 2 2 2 0 BUD22 DUF3446 PF11928.8 ELR22659.1 - 4.2 7.7 18.2 0.18 12.1 12.0 1.9 2 0 0 2 2 2 0 Early growth response N-terminal domain DNA_pol_phi PF04931.13 ELR22659.1 - 4.4 5.3 6.6 7.9 4.4 6.6 1.3 1 0 0 1 1 1 0 DNA polymerase phi PBP1_TM PF14812.6 ELR22659.1 - 5.1 7.5 6.6 10 6.6 6.6 1.4 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal FAD_binding_1 PF00667.20 ELR22660.1 - 4.2e-53 180.2 0.0 5.6e-53 179.8 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain Flavodoxin_1 PF00258.25 ELR22660.1 - 8.1e-30 103.9 0.3 1.5e-29 103.0 0.3 1.5 1 0 0 1 1 1 1 Flavodoxin NAD_binding_1 PF00175.21 ELR22660.1 - 5.6e-11 43.1 0.0 1.2e-10 42.0 0.0 1.6 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain Ribosomal_60s PF00428.19 ELR22660.1 - 0.007 16.9 6.7 0.02 15.5 6.7 1.7 1 0 0 1 1 1 1 60s Acidic ribosomal protein EccE PF11203.8 ELR22660.1 - 0.044 14.1 3.1 3.8 7.9 0.6 3.2 3 0 0 3 3 3 0 Putative type VII ESX secretion system translocon, EccE NTF2 PF02136.20 ELR22661.1 - 1.4e-27 96.6 0.0 2.2e-27 96.0 0.0 1.3 1 0 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain RRM_1 PF00076.22 ELR22661.1 - 5.2e-13 48.6 0.0 7.9e-13 48.0 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 ELR22661.1 - 0.13 12.4 0.0 0.36 10.9 0.0 1.7 1 0 0 1 1 1 0 RNA binding motif Syntaxin_2 PF14523.6 ELR22662.1 - 1.1e-15 57.8 11.6 1.6e-15 57.3 4.1 2.4 2 1 0 2 2 2 1 Syntaxin-like protein SNARE PF05739.19 ELR22662.1 - 2.3e-15 56.3 1.4 5.8e-15 55.0 1.4 1.6 1 0 0 1 1 1 1 SNARE domain Syntaxin PF00804.25 ELR22662.1 - 1.3e-07 31.5 16.3 1.1e-06 28.5 16.3 2.2 1 1 0 1 1 1 1 Syntaxin Prominin PF05478.11 ELR22662.1 - 0.007 14.4 10.1 0.033 12.2 10.1 1.8 1 1 0 1 1 1 1 Prominin MCPsignal PF00015.21 ELR22662.1 - 0.0076 16.1 4.4 0.11 12.3 1.6 2.4 2 0 0 2 2 2 1 Methyl-accepting chemotaxis protein (MCP) signalling domain DUF3923 PF13061.6 ELR22662.1 - 0.043 13.9 0.7 0.079 13.1 0.7 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3923) DUF2383 PF09537.10 ELR22662.1 - 0.044 14.1 1.4 1.9 8.8 0.0 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF2383) Myb_DNA-bind_5 PF13873.6 ELR22662.1 - 0.062 13.4 0.1 0.34 11.0 0.1 2.2 2 0 0 2 2 2 0 Myb/SANT-like DNA-binding domain PSDC PF12588.8 ELR22662.1 - 0.19 11.7 0.8 0.41 10.6 0.2 1.8 2 0 0 2 2 2 0 Phophatidylserine decarboxylase RIFIN PF02009.16 ELR22662.1 - 0.31 10.9 9.5 0.036 14.0 2.6 2.0 1 1 0 2 2 2 0 Rifin TMPIT PF07851.13 ELR22662.1 - 0.38 10.0 6.2 6.5 5.9 0.1 2.2 2 0 0 2 2 2 0 TMPIT-like protein Herpes_US9 PF06072.11 ELR22662.1 - 0.45 10.4 1.9 1.1 9.1 1.9 1.6 1 0 0 1 1 1 0 Alphaherpesvirus tegument protein US9 DUF2203 PF09969.9 ELR22662.1 - 1.4 9.6 5.5 6.9 7.4 0.5 2.7 2 1 1 3 3 3 0 Uncharacterized conserved protein (DUF2203) DUF1664 PF07889.12 ELR22662.1 - 2.3 8.2 9.8 6.7 6.8 3.2 2.9 2 1 0 2 2 2 0 Protein of unknown function (DUF1664) LRR_8 PF13855.6 ELR22663.1 - 1e-58 194.9 73.2 1.9e-08 34.0 0.8 10.6 3 3 8 12 12 12 12 Leucine rich repeat LRR_4 PF12799.7 ELR22663.1 - 6.1e-53 175.9 77.6 2.8e-06 27.6 0.5 13.8 5 3 12 18 18 18 17 Leucine Rich repeats (2 copies) PP2C PF00481.21 ELR22663.1 - 6.2e-52 176.8 0.1 1e-51 176.1 0.1 1.3 1 0 0 1 1 1 1 Protein phosphatase 2C LRR_1 PF00560.33 ELR22663.1 - 5.3e-09 35.4 60.4 0.57 10.9 0.0 19.2 21 2 0 21 21 21 3 Leucine Rich Repeat LRR_9 PF14580.6 ELR22663.1 - 3.4e-07 29.9 27.8 0.37 10.3 0.1 7.1 2 2 4 7 7 7 6 Leucine-rich repeat PP2C_2 PF13672.6 ELR22663.1 - 0.00051 19.7 0.2 0.00091 18.9 0.2 1.3 1 0 0 1 1 1 1 Protein phosphatase 2C CREPT PF16566.5 ELR22663.1 - 0.0074 16.5 2.0 11 6.2 0.0 5.0 6 1 0 6 6 6 1 Cell-cycle alteration and expression-elevated protein in tumour DUF4571 PF15137.6 ELR22663.1 - 0.46 10.1 5.4 2.2 7.9 0.1 3.7 3 2 1 4 4 4 0 Domain of unknown function (DUF4571) DUF601 PF04642.12 ELR22663.1 - 0.85 9.1 8.9 1.9 7.9 8.9 1.5 1 0 0 1 1 1 0 Protein of unknown function, DUF601 Transposase_20 PF02371.16 ELR22664.1 - 0.2 12.0 1.5 0.27 11.6 1.5 1.1 1 0 0 1 1 1 0 Transposase IS116/IS110/IS902 family Pkinase_Tyr PF07714.17 ELR22665.1 - 2.9e-35 121.8 0.0 2.4e-34 118.8 0.0 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ELR22665.1 - 2e-34 119.2 0.0 9.9e-34 116.9 0.0 1.9 1 1 0 1 1 1 1 Protein kinase domain Pkinase_fungal PF17667.1 ELR22665.1 - 0.0046 15.8 0.2 0.012 14.4 0.1 1.5 1 1 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 ELR22665.1 - 0.007 15.8 0.3 0.011 15.0 0.3 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 ELR22665.1 - 0.13 12.2 0.1 0.13 12.2 0.1 1.6 2 0 0 2 2 2 0 Phosphotransferase enzyme family ADH_zinc_N_2 PF13602.6 ELR22666.1 - 6e-19 69.4 0.8 1.5e-18 68.1 0.4 1.9 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.26 ELR22666.1 - 2.3e-12 47.0 0.6 5.3e-12 45.9 0.3 1.8 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_N PF08240.12 ELR22666.1 - 2e-11 43.7 0.0 4.6e-11 42.6 0.0 1.7 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ELFV_dehydrog PF00208.21 ELR22666.1 - 0.014 15.2 0.0 0.022 14.5 0.0 1.3 1 0 0 1 1 1 0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase NmrA PF05368.13 ELR22666.1 - 0.11 12.0 0.5 0.18 11.3 0.5 1.3 1 0 0 1 1 1 0 NmrA-like family Epimerase PF01370.21 ELR22666.1 - 0.13 11.7 0.3 0.22 11.0 0.3 1.3 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family DapB_N PF01113.20 ELR22666.1 - 0.16 12.1 0.4 0.36 10.9 0.1 1.8 2 0 0 2 2 2 0 Dihydrodipicolinate reductase, N-terminus DJ-1_PfpI PF01965.24 ELR22667.1 - 1.3e-08 34.8 0.0 3.2e-08 33.6 0.0 1.6 1 1 0 1 1 1 1 DJ-1/PfpI family Ank_2 PF12796.7 ELR22668.1 - 3.3e-24 85.3 0.0 1.3e-07 32.1 0.0 4.7 2 1 2 4 4 4 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ELR22668.1 - 2.9e-20 72.4 1.0 0.0026 18.3 0.0 9.5 7 3 1 8 8 8 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 ELR22668.1 - 9.2e-19 65.6 5.4 0.11 13.1 0.0 10.9 11 1 1 12 12 12 4 Ankyrin repeat Ank_5 PF13857.6 ELR22668.1 - 4.4e-12 46.0 10.3 0.1 12.9 0.0 8.3 8 3 2 10 10 10 3 Ankyrin repeats (many copies) F-box-like PF12937.7 ELR22668.1 - 2.4e-11 43.3 1.4 3.6e-11 42.8 0.3 1.9 2 0 0 2 2 2 1 F-box-like Ank PF00023.30 ELR22668.1 - 6.8e-10 38.9 23.8 0.18 12.3 0.1 10.1 11 1 1 12 12 12 4 Ankyrin repeat F-box PF00646.33 ELR22668.1 - 3.8e-07 29.8 0.1 1.9e-06 27.6 0.1 2.1 2 0 0 2 2 2 1 F-box domain F-box_4 PF15966.5 ELR22668.1 - 0.00043 20.1 0.0 0.00085 19.2 0.0 1.4 1 0 0 1 1 1 1 F-box NAP PF00956.18 ELR22669.1 - 3.9e-68 229.6 17.7 3.2e-67 226.6 17.7 1.9 1 1 0 1 1 1 1 Nucleosome assembly protein (NAP) ING PF12998.7 ELR22669.1 - 0.021 15.4 1.4 0.056 14.0 1.4 1.7 1 1 0 1 1 1 0 Inhibitor of growth proteins N-terminal histone-binding BT1 PF03092.16 ELR22669.1 - 0.35 9.0 0.1 0.48 8.6 0.1 1.1 1 0 0 1 1 1 0 BT1 family Striatin PF08232.12 ELR22669.1 - 0.94 10.1 12.1 2.1 8.9 12.1 1.5 1 1 0 1 1 1 0 Striatin family Pkinase PF00069.25 ELR22670.1 - 3.3e-79 266.0 0.0 4.3e-79 265.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR22670.1 - 2.6e-37 128.5 0.0 3.6e-37 128.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ELR22670.1 - 9e-06 25.2 0.1 0.021 14.2 0.0 2.3 2 0 0 2 2 2 2 Kinase-like Pkinase_C PF00433.24 ELR22670.1 - 0.00014 22.5 1.0 0.00031 21.4 1.0 1.6 1 0 0 1 1 1 1 Protein kinase C terminal domain Pkinase_fungal PF17667.1 ELR22670.1 - 0.00034 19.5 0.0 0.00047 19.1 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Haspin_kinase PF12330.8 ELR22670.1 - 0.00087 18.3 0.1 0.0012 17.9 0.1 1.2 1 0 0 1 1 1 1 Haspin like kinase domain FTA2 PF13095.6 ELR22670.1 - 0.0047 16.6 0.3 1.6 8.3 0.2 2.2 2 0 0 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 APH PF01636.23 ELR22670.1 - 0.083 12.8 0.0 0.12 12.2 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Tubulin PF00091.25 ELR22671.1 - 2.3e-69 233.5 0.0 3.4e-69 233.0 0.0 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 ELR22671.1 - 2.4e-35 121.5 0.0 3.6e-35 120.9 0.0 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Misat_Tub_SegII PF10644.9 ELR22671.1 - 0.0002 21.6 0.0 0.062 13.6 0.1 2.5 2 0 0 2 2 2 2 Misato Segment II tubulin-like domain Tubulin_3 PF14881.6 ELR22671.1 - 0.00046 19.9 0.0 0.00088 19.0 0.0 1.5 1 0 0 1 1 1 1 Tubulin domain Tubulin_2 PF13809.6 ELR22671.1 - 0.15 11.2 0.0 0.24 10.5 0.0 1.3 1 0 0 1 1 1 0 Tubulin like Multi_ubiq PF14452.6 ELR22674.1 - 0.073 13.3 0.0 0.12 12.6 0.0 1.3 1 0 0 1 1 1 0 Multiubiquitin BAG PF02179.16 ELR22675.1 - 4.9e-12 46.1 1.0 4.9e-12 46.1 1.0 3.9 3 1 0 3 3 3 1 BAG domain HSP20 PF00011.21 ELR22675.1 - 2.7e-06 27.5 0.9 0.0032 17.6 0.0 3.2 3 0 0 3 3 3 2 Hsp20/alpha crystallin family SPX PF03105.19 ELR22675.1 - 0.0018 18.3 21.4 0.057 13.3 0.6 2.6 2 0 0 2 2 2 2 SPX domain ArsA_HSP20 PF17886.1 ELR22675.1 - 0.13 11.8 0.0 0.41 10.2 0.0 1.9 2 0 0 2 2 2 0 HSP20-like domain found in ArsA DUF948 PF06103.11 ELR22675.1 - 0.91 9.8 3.4 11 6.3 0.4 3.1 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) NPV_P10 PF05531.12 ELR22675.1 - 1.9 9.0 8.5 4.7 7.8 1.4 3.0 3 0 0 3 3 3 0 Nucleopolyhedrovirus P10 protein DUF4363 PF14276.6 ELR22675.1 - 3 8.0 9.2 11 6.2 1.1 3.6 2 1 1 3 3 3 0 Domain of unknown function (DUF4363) Ank_4 PF13637.6 ELR22676.1 - 1.2e-16 60.9 0.4 8.3e-12 45.4 0.1 2.2 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 ELR22676.1 - 2.2e-16 59.7 3.5 5.4e-09 36.1 0.4 2.3 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 ELR22676.1 - 7.4e-15 54.6 0.8 1.5e-06 28.4 0.1 2.5 2 0 0 2 2 2 2 Ankyrin repeat Ank_2 PF12796.7 ELR22676.1 - 2.5e-13 50.4 0.0 3.7e-13 49.9 0.0 1.3 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 ELR22676.1 - 8.2e-10 38.1 0.1 4.2e-05 23.6 0.0 2.8 2 0 0 2 2 2 2 Ankyrin repeat DUF4988 PF16378.5 ELR22676.1 - 0.065 12.9 0.0 0.088 12.5 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function LRR_8 PF13855.6 ELR22678.1 - 2.6e-14 52.7 2.6 7.1e-09 35.3 0.2 3.0 2 1 1 3 3 3 2 Leucine rich repeat LRR_4 PF12799.7 ELR22678.1 - 3.1e-13 49.7 5.5 0.0001 22.6 0.2 3.8 3 1 1 4 4 4 3 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 ELR22678.1 - 2.5e-05 24.2 2.6 4.8 8.1 0.0 5.2 5 0 0 5 5 5 1 Leucine Rich Repeat LRR_6 PF13516.6 ELR22678.1 - 0.00083 19.2 5.4 1.3 9.2 0.0 4.4 4 0 0 4 4 4 1 Leucine Rich repeat LRR_9 PF14580.6 ELR22678.1 - 0.032 13.7 2.3 1.3 8.5 0.1 2.0 1 1 1 2 2 2 0 Leucine-rich repeat LRR_8 PF13855.6 ELR22679.1 - 3.6e-18 65.1 9.5 2.4e-08 33.6 0.2 3.8 2 2 2 4 4 4 4 Leucine rich repeat LRR_4 PF12799.7 ELR22679.1 - 3.9e-14 52.5 15.1 0.00034 20.9 0.2 4.7 2 1 3 5 5 5 4 Leucine Rich repeats (2 copies) F-box-like PF12937.7 ELR22679.1 - 1.4e-09 37.7 0.0 4.3e-09 36.1 0.0 1.9 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ELR22679.1 - 2.9e-05 23.8 0.0 0.00022 21.0 0.0 2.4 2 0 0 2 2 2 1 F-box domain LRR_1 PF00560.33 ELR22679.1 - 0.0073 16.7 13.9 15 6.7 0.0 6.6 6 0 0 6 6 6 1 Leucine Rich Repeat LRR_9 PF14580.6 ELR22679.1 - 0.011 15.3 6.2 0.72 9.3 1.5 3.1 1 1 0 2 2 2 0 Leucine-rich repeat LRR_6 PF13516.6 ELR22679.1 - 3.3 8.0 15.0 3.8 7.8 0.0 5.6 6 0 0 6 6 6 0 Leucine Rich repeat ZapB PF06005.12 ELR22680.1 - 0.00063 20.1 8.0 0.001 19.5 8.0 1.4 1 0 0 1 1 1 1 Cell division protein ZapB DUF3450 PF11932.8 ELR22680.1 - 0.00079 18.8 2.9 0.00091 18.6 2.9 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3450) zf_CCCH_4 PF18345.1 ELR22680.1 - 0.026 14.6 0.3 0.042 13.9 0.3 1.3 1 0 0 1 1 1 0 Zinc finger domain bZIP_1 PF00170.21 ELR22680.1 - 0.03 14.4 10.2 0.047 13.8 8.3 1.9 1 1 1 2 2 2 0 bZIP transcription factor Codanin-1_C PF15296.6 ELR22680.1 - 0.037 14.1 0.1 0.053 13.6 0.1 1.2 1 0 0 1 1 1 0 Codanin-1 C-terminus OmpH PF03938.14 ELR22680.1 - 0.059 13.7 1.9 0.067 13.5 1.9 1.1 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) Cnn_1N PF07989.11 ELR22680.1 - 0.079 13.1 8.9 0.61 10.3 8.9 2.0 1 1 0 1 1 1 0 Centrosomin N-terminal motif 1 zf-CCCH PF00642.24 ELR22680.1 - 0.09 12.7 0.1 0.14 12.2 0.1 1.3 1 0 0 1 1 1 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Cep57_CLD_2 PF14197.6 ELR22680.1 - 0.092 12.8 9.9 0.17 12.0 9.9 1.5 1 0 0 1 1 1 0 Centrosome localisation domain of PPC89 bZIP_2 PF07716.15 ELR22680.1 - 0.12 12.5 13.4 0.16 12.1 5.6 2.2 1 1 1 2 2 2 0 Basic region leucine zipper YabA PF06156.13 ELR22680.1 - 0.16 12.6 6.9 0.46 11.2 6.9 1.8 1 1 0 1 1 1 0 Initiation control protein YabA UPF0242 PF06785.11 ELR22680.1 - 0.36 10.9 6.6 0.42 10.7 6.6 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus DivIC PF04977.15 ELR22680.1 - 0.48 10.2 8.9 0.39 10.5 3.0 2.0 1 1 1 2 2 2 0 Septum formation initiator TSC22 PF01166.18 ELR22680.1 - 0.5 10.7 9.8 7.5 6.9 6.0 2.7 1 1 1 2 2 2 0 TSC-22/dip/bun family DUF3958 PF13125.6 ELR22680.1 - 0.71 10.1 13.1 0.27 11.4 6.5 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3958) FtsL PF04999.13 ELR22680.1 - 0.71 9.9 5.4 1.2 9.2 5.3 1.3 1 1 0 1 1 1 0 Cell division protein FtsL HALZ PF02183.18 ELR22680.1 - 0.73 10.1 10.3 6 7.2 1.8 2.8 1 1 2 3 3 3 0 Homeobox associated leucine zipper NRBF2 PF08961.10 ELR22680.1 - 0.85 9.2 11.6 6.1 6.4 11.6 2.0 1 1 0 1 1 1 0 Nuclear receptor-binding factor 2, autophagy regulator DUF3658 PF12395.8 ELR22680.1 - 1.9 8.4 5.8 5 7.1 0.5 2.1 1 1 1 2 2 2 0 Protein of unknown function Shugoshin_N PF07558.11 ELR22680.1 - 4.4 7.3 10.0 3.9 7.4 1.1 2.4 2 1 0 2 2 2 0 Shugoshin N-terminal coiled-coil region APC_N_CC PF16689.5 ELR22680.1 - 6.5 6.9 10.1 1.9 8.6 1.3 2.5 1 1 1 2 2 2 0 Coiled-coil N-terminus of APC, dimerisation domain PDT PF00800.18 ELR22681.1 - 4.8e-53 179.7 0.0 1.2e-52 178.5 0.0 1.6 2 0 0 2 2 2 1 Prephenate dehydratase CM_2 PF01817.21 ELR22681.1 - 4.2e-09 36.6 2.2 0.13 12.6 0.0 3.7 3 0 0 3 3 3 3 Chorismate mutase type II ACT PF01842.25 ELR22681.1 - 5.9e-08 32.3 0.0 1.3e-07 31.2 0.0 1.6 1 0 0 1 1 1 1 ACT domain DUF5093 PF17011.5 ELR22681.1 - 0.0011 19.3 0.3 2.6 8.3 0.0 2.5 2 0 0 2 2 2 2 Domain of unknown function (DUF5093) CotJA PF11007.8 ELR22681.1 - 0.044 13.6 0.0 16 5.4 0.0 2.7 2 0 0 2 2 2 0 Spore coat associated protein JA (CotJA) STAT_int PF02865.17 ELR22681.1 - 0.14 12.6 0.0 16 6.0 0.0 2.7 2 0 0 2 2 2 0 STAT protein, protein interaction domain SAC3_GANP PF03399.16 ELR22681.1 - 0.16 11.3 0.0 0.28 10.5 0.0 1.3 1 0 0 1 1 1 0 SAC3/GANP family YebO PF13974.6 ELR22682.1 - 0.0079 16.3 0.8 0.02 14.9 0.0 2.0 2 0 0 2 2 2 1 YebO-like protein Ribosomal_60s PF00428.19 ELR22682.1 - 0.026 15.1 0.9 0.061 13.9 0.9 1.6 1 0 0 1 1 1 0 60s Acidic ribosomal protein Myosin_head PF00063.21 ELR22682.1 - 0.058 11.6 0.0 0.072 11.3 0.0 1.1 1 0 0 1 1 1 0 Myosin head (motor domain) Alg14 PF08660.11 ELR22683.1 - 1.1e-65 220.8 0.0 1.6e-65 220.3 0.0 1.2 1 0 0 1 1 1 1 Oligosaccharide biosynthesis protein Alg14 like Cytochrom_B561 PF03188.16 ELR22684.1 - 1.4e-18 67.4 9.1 1.4e-18 67.4 9.1 2.4 3 0 0 3 3 3 1 Eukaryotic cytochrome b561 TMEM132D_C PF15706.5 ELR22684.1 - 0.2 11.5 0.3 1.8 8.4 0.4 2.2 2 0 0 2 2 2 0 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term DUF3995 PF13160.6 ELR22684.1 - 0.22 11.9 11.9 1.3 9.4 2.3 2.9 1 1 2 3 3 3 0 Protein of unknown function (DUF3995) Atthog PF18800.1 ELR22684.1 - 0.28 11.1 5.4 3 7.7 0.4 2.2 2 0 0 2 2 2 0 Attenuator of Hedgehog ABC2_membrane_2 PF12679.7 ELR22684.1 - 1.8 7.8 7.1 8 5.6 7.1 1.8 1 1 0 1 1 1 0 ABC-2 family transporter protein MARVEL PF01284.23 ELR22684.1 - 7.7 6.5 17.0 13 5.9 8.1 2.5 1 1 1 2 2 2 0 Membrane-associating domain FHA PF00498.26 ELR22685.1 - 6.6e-18 64.8 0.4 1.2e-17 64.0 0.4 1.5 1 0 0 1 1 1 1 FHA domain Yop-YscD_cpl PF16697.5 ELR22685.1 - 3.6e-09 36.8 0.1 4.8e-05 23.6 0.2 2.9 1 1 1 2 2 2 2 Inner membrane component of T3SS, cytoplasmic domain Mgm101p PF06420.12 ELR22686.1 - 4.4e-57 192.3 0.0 5.5e-57 192.0 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial genome maintenance MGM101 CENP-B_dimeris PF09026.10 ELR22686.1 - 0.0065 16.8 4.3 0.012 16.0 4.3 1.3 1 0 0 1 1 1 1 Centromere protein B dimerisation domain Gpi1 PF05024.15 ELR22687.1 - 4.6e-35 121.4 8.0 9.4e-35 120.4 8.0 1.5 1 0 0 1 1 1 1 N-acetylglucosaminyl transferase component (Gpi1) F-box-like PF12937.7 ELR22688.1 - 0.0025 17.7 0.0 0.0048 16.8 0.0 1.4 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ELR22688.1 - 0.011 15.6 0.4 0.03 14.2 0.1 1.7 2 0 0 2 2 2 0 F-box domain NPR3 PF03666.13 ELR22688.1 - 0.54 9.0 2.7 0.67 8.7 2.7 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 DUF809 PF05663.11 ELR22688.1 - 1.6 8.9 5.7 3.4 7.8 5.7 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF809) NARP1 PF12569.8 ELR22688.1 - 5.6 5.8 8.3 6.5 5.5 8.3 1.0 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 COesterase PF00135.28 ELR22689.1 - 8.9e-23 80.9 0.1 1.4e-22 80.3 0.1 1.2 1 0 0 1 1 1 1 Carboxylesterase family NUDIX PF00293.28 ELR22690.1 - 0.0083 16.2 0.4 0.036 14.1 0.4 1.9 1 1 0 1 1 1 1 NUDIX domain CTP_transf_like PF01467.26 ELR22691.1 - 2.1e-18 66.9 0.0 3.1e-18 66.4 0.0 1.3 1 0 0 1 1 1 1 Cytidylyltransferase-like FAD_syn PF06574.12 ELR22691.1 - 0.037 13.9 0.5 0.12 12.3 0.5 1.9 1 1 0 1 1 1 0 FAD synthetase eIF-3c_N PF05470.12 ELR22691.1 - 0.2 9.9 8.0 0.049 11.9 0.7 2.0 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit 8 N-terminus Selenoprotein_S PF06936.11 ELR22691.1 - 0.31 10.8 3.9 0.62 9.8 3.9 1.4 1 0 0 1 1 1 0 Selenoprotein S (SelS) Mgm101p PF06420.12 ELR22692.1 - 2.4e-65 219.2 0.0 3.5e-65 218.7 0.0 1.3 1 0 0 1 1 1 1 Mitochondrial genome maintenance MGM101 FSA_C PF10479.9 ELR22692.1 - 0.058 11.5 3.2 0.097 10.8 3.2 1.2 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus SR-25 PF10500.9 ELR22692.1 - 0.32 10.6 5.9 0.52 9.9 5.9 1.4 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Med3 PF11593.8 ELR22692.1 - 6.5 5.8 6.9 8.8 5.4 6.9 1.1 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal Gpi1 PF05024.15 ELR22693.1 - 4.4e-58 196.5 6.3 7.3e-58 195.7 6.3 1.4 1 0 0 1 1 1 1 N-acetylglucosaminyl transferase component (Gpi1) Phage_holin_3_6 PF07332.11 ELR22693.1 - 0.12 12.4 0.2 0.12 12.4 0.2 3.7 3 1 1 4 4 4 0 Putative Actinobacterial Holin-X, holin superfamily III Pkinase PF00069.25 ELR22694.1 - 8.7e-22 77.7 0.0 1.5e-21 77.0 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain WD40 PF00400.32 ELR22694.1 - 2.1e-13 50.5 9.9 1.3e-05 25.9 0.2 6.2 5 0 0 5 5 5 2 WD domain, G-beta repeat Pkinase_Tyr PF07714.17 ELR22694.1 - 1.6e-09 37.5 0.0 2.5e-09 36.8 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase HEAT PF02985.22 ELR22694.1 - 4.7e-08 32.6 2.2 0.17 12.2 0.1 4.3 4 0 0 4 4 4 3 HEAT repeat HEAT_2 PF13646.6 ELR22694.1 - 0.00025 21.4 0.0 0.13 12.7 0.0 2.7 2 0 0 2 2 2 1 HEAT repeats APH PF01636.23 ELR22694.1 - 0.016 15.2 0.0 0.12 12.3 0.0 2.2 2 0 0 2 2 2 0 Phosphotransferase enzyme family HEAT_EZ PF13513.6 ELR22694.1 - 0.02 15.4 0.1 0.087 13.4 0.1 2.2 1 0 0 1 1 1 0 HEAT-like repeat RTP1_C1 PF10363.9 ELR22694.1 - 0.047 13.9 0.2 9.9 6.4 0.0 2.6 2 0 0 2 2 2 0 Required for nuclear transport of RNA pol II C-terminus 1 Adaptin_N PF01602.20 ELR22694.1 - 0.14 10.7 0.0 8.4 4.8 0.0 2.3 2 0 0 2 2 2 0 Adaptin N terminal region Kinase-like PF14531.6 ELR22694.1 - 0.17 11.2 0.0 0.3 10.3 0.0 1.4 1 0 0 1 1 1 0 Kinase-like Nucleoporin_N PF08801.11 ELR22694.1 - 0.2 10.4 10.4 1.1 7.9 3.4 3.6 2 2 1 3 3 3 0 Nup133 N terminal like Pkinase_Tyr PF07714.17 ELR22695.1 - 2.9e-26 92.3 0.1 3.3e-26 92.1 0.1 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ELR22695.1 - 4e-18 65.7 0.0 4.9e-18 65.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain NAD_binding_10 PF13460.6 ELR22696.1 - 5.6e-06 26.4 0.0 7e-06 26.1 0.0 1.1 1 0 0 1 1 1 1 NAD(P)H-binding WWE PF02825.20 ELR22697.1 - 4.4e-10 40.0 2.6 1.1e-09 38.8 2.6 1.7 1 0 0 1 1 1 1 WWE domain BRCT_2 PF16589.5 ELR22697.1 - 6.8e-06 26.4 0.0 1.7e-05 25.2 0.0 1.6 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain BRCT PF00533.26 ELR22697.1 - 1.6e-05 25.2 0.0 3.4e-05 24.1 0.0 1.5 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain PTCB-BRCT PF12738.7 ELR22697.1 - 0.0009 19.2 0.1 0.0017 18.3 0.1 1.5 1 0 0 1 1 1 1 twin BRCT domain SLC12 PF03522.15 ELR22697.1 - 1.5 7.7 7.9 2.4 7.1 7.9 1.2 1 0 0 1 1 1 0 Solute carrier family 12 tRNA-synt_1b PF00579.25 ELR22697.1 - 3.3 7.0 7.2 0.56 9.5 0.5 2.1 2 0 0 2 2 2 0 tRNA synthetases class I (W and Y) NAD_binding_10 PF13460.6 ELR22699.1 - 1.7e-06 28.0 0.0 2e-06 27.8 0.0 1.0 1 0 0 1 1 1 1 NAD(P)H-binding Semialdhyde_dh PF01118.24 ELR22699.1 - 5.5e-06 26.8 0.0 6.1e-06 26.7 0.0 1.0 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain Sacchrp_dh_NADP PF03435.18 ELR22699.1 - 0.00086 19.6 0.0 0.00095 19.4 0.0 1.0 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain Epimerase PF01370.21 ELR22699.1 - 0.0015 18.0 0.0 0.0015 18.0 0.0 1.0 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 ELR22699.1 - 0.0045 16.2 0.0 0.0046 16.1 0.0 1.0 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein KR PF08659.10 ELR22699.1 - 0.005 16.8 0.0 0.0054 16.7 0.0 1.1 1 0 0 1 1 1 1 KR domain 3Beta_HSD PF01073.19 ELR22699.1 - 0.0087 15.1 0.1 0.0089 15.1 0.1 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.12 ELR22699.1 - 0.013 14.7 0.0 0.014 14.6 0.0 1.0 1 0 0 1 1 1 0 Male sterility protein DapB_N PF01113.20 ELR22699.1 - 0.02 15.0 0.0 0.022 14.9 0.0 1.0 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus NmrA PF05368.13 ELR22699.1 - 0.033 13.7 0.0 0.037 13.6 0.0 1.0 1 0 0 1 1 1 0 NmrA-like family TrkA_N PF02254.18 ELR22699.1 - 0.041 14.2 0.0 0.051 13.8 0.0 1.2 1 0 0 1 1 1 0 TrkA-N domain RmlD_sub_bind PF04321.17 ELR22699.1 - 0.061 12.4 0.0 0.065 12.3 0.0 1.0 1 0 0 1 1 1 0 RmlD substrate binding domain CbiJ PF02571.14 ELR22699.1 - 0.089 12.3 0.0 0.097 12.1 0.0 1.0 1 0 0 1 1 1 0 Precorrin-6x reductase CbiJ/CobK F420_oxidored PF03807.17 ELR22699.1 - 0.14 12.8 0.0 0.18 12.4 0.0 1.2 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent Pkinase_Tyr PF07714.17 ELR22700.1 - 1e-47 162.6 0.1 1.5e-47 162.1 0.1 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ELR22700.1 - 2e-44 152.0 0.0 2.7e-44 151.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain SKG6 PF08693.10 ELR22700.1 - 2.3e-06 26.9 10.4 0.00028 20.2 10.4 2.5 1 1 0 1 1 1 1 Transmembrane alpha-helix domain EGF_2 PF07974.13 ELR22700.1 - 4.7e-05 23.7 6.4 7.8e-05 23.0 6.4 1.4 1 0 0 1 1 1 1 EGF-like domain FTA2 PF13095.6 ELR22700.1 - 0.00022 20.9 0.0 0.0082 15.8 0.0 2.2 1 1 1 2 2 2 1 Kinetochore Sim4 complex subunit FTA2 ArsP_1 PF03773.13 ELR22700.1 - 0.0012 18.1 0.5 0.0024 17.1 0.2 1.5 1 1 1 2 2 2 1 Predicted permease Kinase-like PF14531.6 ELR22700.1 - 0.0032 16.8 0.0 0.0052 16.1 0.0 1.4 1 1 0 1 1 1 1 Kinase-like TMEM154 PF15102.6 ELR22700.1 - 0.0068 16.3 0.0 0.013 15.4 0.0 1.5 1 0 0 1 1 1 1 TMEM154 protein family Stevor PF17410.2 ELR22700.1 - 0.0092 15.6 0.1 0.02 14.4 0.1 1.5 1 0 0 1 1 1 1 Subtelomeric Variable Open Reading frame HMD PF03201.16 ELR22700.1 - 0.029 14.6 0.1 0.029 14.6 0.1 2.1 2 0 0 2 2 2 0 H2-forming N5,N10-methylene-tetrahydromethanopterin dehydrogenase DUF3377 PF11857.8 ELR22700.1 - 0.03 14.3 0.2 0.078 12.9 0.2 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF3377) EGF PF00008.27 ELR22700.1 - 0.033 14.5 3.6 0.053 13.8 3.6 1.4 1 0 0 1 1 1 0 EGF-like domain Kdo PF06293.14 ELR22700.1 - 0.073 12.4 0.1 0.13 11.6 0.1 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Gram_pos_anchor PF00746.21 ELR22700.1 - 0.09 12.7 1.3 0.24 11.4 1.3 1.8 1 0 0 1 1 1 0 LPXTG cell wall anchor motif RIO1 PF01163.22 ELR22700.1 - 0.1 12.2 1.1 0.88 9.1 0.2 2.0 1 1 1 2 2 2 0 RIO1 family Pkinase_fungal PF17667.1 ELR22700.1 - 0.16 10.7 0.1 0.59 8.8 0.0 1.8 2 0 0 2 2 2 0 Fungal protein kinase WWE PF02825.20 ELR22701.1 - 2e-10 41.1 1.7 2.3e-10 40.9 1.7 1.1 1 0 0 1 1 1 1 WWE domain Thioredoxin PF00085.20 ELR22703.1 - 5.2e-17 61.7 0.0 9.3e-17 60.9 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_9 PF14595.6 ELR22703.1 - 3.1e-05 23.7 0.0 4.7e-05 23.2 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.6 ELR22703.1 - 0.0017 18.8 0.1 0.011 16.1 0.0 2.2 2 1 0 2 2 2 1 Thioredoxin-like domain PSK_trans_fac PF07704.11 ELR22703.1 - 0.011 16.5 5.5 0.016 15.9 2.3 2.5 2 0 0 2 2 2 0 Rv0623-like transcription factor HyaE PF07449.11 ELR22703.1 - 0.027 14.4 0.1 0.07 13.1 0.0 1.7 2 0 0 2 2 2 0 Hydrogenase-1 expression protein HyaE Thioredoxin_3 PF13192.6 ELR22703.1 - 0.031 14.3 0.1 0.13 12.4 0.0 2.0 1 1 1 2 2 2 0 Thioredoxin domain Thioredoxin_8 PF13905.6 ELR22703.1 - 0.046 14.1 0.1 9.9 6.6 0.0 2.2 1 1 1 2 2 2 0 Thioredoxin-like DUF2075 PF09848.9 ELR22705.1 - 0.12 11.6 0.0 0.13 11.4 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) Nha1_C PF08619.10 ELR22707.1 - 0.11 11.7 2.4 0.15 11.2 2.4 1.1 1 0 0 1 1 1 0 Alkali metal cation/H+ antiporter Nha1 C terminus SAM_1 PF00536.30 ELR22708.1 - 0.0012 19.3 0.2 0.0028 18.1 0.2 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 ELR22708.1 - 0.028 14.5 0.1 0.051 13.7 0.1 1.4 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) SAM_Ste50p PF09235.10 ELR22708.1 - 0.053 13.8 0.0 0.087 13.1 0.0 1.3 1 0 0 1 1 1 0 Ste50p, sterile alpha motif Ank_4 PF13637.6 ELR22710.1 - 1.4e-12 47.8 0.0 6e-09 36.3 0.0 2.7 3 0 0 3 3 3 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 ELR22710.1 - 2.8e-12 47.0 0.0 5.3e-11 43.0 0.0 2.3 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 ELR22710.1 - 1.9e-11 44.0 0.9 0.0024 18.1 0.0 3.8 3 1 1 4 4 4 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 ELR22710.1 - 8.7e-11 41.1 0.0 0.0073 16.7 0.0 4.0 4 0 0 4 4 4 2 Ankyrin repeat Ank PF00023.30 ELR22710.1 - 1.3e-09 38.0 0.1 0.0028 18.0 0.0 3.7 4 0 0 4 4 4 2 Ankyrin repeat Pyr_redox_2 PF07992.14 ELR22711.1 - 7e-08 32.0 0.0 1.3e-07 31.1 0.0 1.4 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase DUF150_C PF17384.2 ELR22713.1 - 0.12 12.5 0.1 0.33 11.1 0.0 1.7 2 0 0 2 2 2 0 RimP C-terminal SH3 domain Cellulase PF00150.18 ELR22716.1 - 6.5e-05 22.5 7.9 0.00098 18.6 6.2 2.0 1 1 1 2 2 2 2 Cellulase (glycosyl hydrolase family 5) Zip PF02535.22 ELR22717.1 - 3.9e-19 69.1 17.8 9.6e-16 57.9 3.9 2.2 2 0 0 2 2 2 2 ZIP Zinc transporter E1-E2_ATPase PF00122.20 ELR22717.1 - 0.73 9.3 3.2 0.56 9.7 0.7 2.1 1 1 0 1 1 1 0 E1-E2 ATPase SLATT_fungal PF18142.1 ELR22717.1 - 1 9.4 6.5 0.39 10.7 0.8 2.3 2 0 0 2 2 2 0 SMODS and SLOG-associating 2TM effector domain UPRTase PF14681.6 ELR22719.1 - 1.3e-79 266.4 0.0 1.6e-79 266.1 0.0 1.1 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase Pribosyltran PF00156.27 ELR22719.1 - 3.6e-06 26.6 0.0 7.5e-06 25.5 0.0 1.5 1 1 0 1 1 1 1 Phosphoribosyl transferase domain CENP-B_dimeris PF09026.10 ELR22720.1 - 1.1 9.7 5.0 54 4.3 6.5 2.2 2 0 0 2 2 2 0 Centromere protein B dimerisation domain I_LWEQ PF01608.17 ELR22721.1 - 1e-35 123.2 6.8 1e-35 123.2 6.8 2.3 2 0 0 2 2 2 1 I/LWEQ domain zf-RanBP PF00641.18 ELR22721.1 - 4.3e-06 25.9 2.9 7.8e-06 25.1 2.9 1.4 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others PH PF00169.29 ELR22721.1 - 2.3e-05 24.8 0.1 5.3e-05 23.7 0.1 1.6 1 0 0 1 1 1 1 PH domain DUF1110 PF06533.12 ELR22721.1 - 0.0086 16.1 7.5 0.0086 16.1 7.5 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF1110) DZR PF12773.7 ELR22721.1 - 0.08 13.0 1.3 0.15 12.1 1.3 1.3 1 0 0 1 1 1 0 Double zinc ribbon DUF1484 PF07363.11 ELR22721.1 - 5.8 8.0 11.5 0.077 14.0 3.7 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1484) PPR_3 PF13812.6 ELR22722.1 - 3e-50 168.1 0.0 3.1e-12 46.4 0.0 8.7 7 2 2 9 9 9 7 Pentatricopeptide repeat domain PPR_2 PF13041.6 ELR22722.1 - 1.8e-47 159.3 0.5 1.3e-06 28.5 0.1 10.7 8 3 4 12 12 12 9 PPR repeat family PPR_long PF17177.4 ELR22722.1 - 9.3e-24 84.0 13.9 9.7e-10 38.2 1.0 5.3 1 1 2 3 3 3 3 Pentacotripeptide-repeat region of PRORP PPR_1 PF12854.7 ELR22722.1 - 4.9e-13 48.5 17.2 0.089 12.5 0.1 10.9 11 0 0 11 11 11 4 PPR repeat PPR PF01535.20 ELR22722.1 - 8e-11 41.4 26.5 0.28 11.5 0.0 12.0 13 0 0 13 13 13 4 PPR repeat Exog_C PF18026.1 ELR22722.1 - 0.0084 16.1 0.0 1 9.4 0.0 4.2 7 0 0 7 7 7 1 Endo/exonuclease (EXOG) C-terminal domain ECSIT PF06239.11 ELR22722.1 - 0.012 14.8 0.0 0.091 11.9 0.0 2.4 3 0 0 3 3 3 0 Evolutionarily conserved signalling intermediate in Toll pathway MRP-S27 PF10037.9 ELR22722.1 - 0.025 13.4 0.0 0.15 10.9 0.0 2.0 2 0 0 2 2 2 0 Mitochondrial 28S ribosomal protein S27 CBP_BcsN PF17038.5 ELR22722.1 - 0.092 12.1 0.1 3.1 7.1 0.0 2.5 2 0 0 2 2 2 0 Cellulose biosynthesis protein BcsN Methyltransf_28 PF02636.17 ELR22723.1 - 3e-59 200.8 0.0 7.2e-58 196.3 0.0 2.2 1 1 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase Osteopontin PF00865.18 ELR22723.1 - 0.027 14.0 0.0 0.045 13.2 0.0 1.2 1 0 0 1 1 1 0 Osteopontin Ldh_2 PF02615.14 ELR22724.1 - 7.3e-84 281.8 0.1 2.4e-82 276.8 0.1 2.0 1 1 0 1 1 1 1 Malate/L-lactate dehydrogenase RabGAP-TBC PF00566.18 ELR22725.1 - 5.3e-41 140.6 0.0 9.5e-41 139.8 0.0 1.3 1 0 0 1 1 1 1 Rab-GTPase-TBC domain GRAM PF02893.20 ELR22725.1 - 6.2e-13 48.6 1.4 1.2e-05 25.1 0.0 2.8 3 0 0 3 3 3 2 GRAM domain Rotamase_3 PF13616.6 ELR22725.1 - 0.043 14.4 0.2 0.18 12.4 0.1 2.0 2 0 0 2 2 2 0 PPIC-type PPIASE domain zf-CCHC PF00098.23 ELR22726.1 - 9.7e-19 66.5 29.9 3.5e-06 26.8 3.1 4.3 4 0 0 4 4 4 4 Zinc knuckle zf-CCHC_2 PF13696.6 ELR22726.1 - 0.00077 19.2 25.1 0.021 14.7 0.9 4.2 4 0 0 4 4 4 3 Zinc knuckle zf-CCHC_4 PF14392.6 ELR22726.1 - 0.012 15.3 27.6 0.12 12.1 0.5 4.4 4 0 0 4 4 4 0 Zinc knuckle zf-CCHC_3 PF13917.6 ELR22726.1 - 0.15 12.0 20.5 3.7 7.6 1.1 4.8 2 1 2 4 4 4 0 Zinc knuckle IBR PF01485.21 ELR22726.1 - 1.2 9.4 0.0 1.2 9.4 0.0 3.5 2 1 0 2 2 2 0 IBR domain, a half RING-finger domain ZZ PF00569.17 ELR22726.1 - 1.6 8.6 8.4 1.4 8.8 4.9 2.4 2 0 0 2 2 2 0 Zinc finger, ZZ type zf-ribbon_3 PF13248.6 ELR22726.1 - 2.8 7.5 7.1 9.4 5.8 0.3 3.4 3 0 0 3 3 3 0 zinc-ribbon domain TMEM18 PF14770.6 ELR22727.1 - 4.6e-37 126.6 6.6 6.2e-37 126.2 6.6 1.2 1 0 0 1 1 1 1 Transmembrane protein 18 MFS_2 PF13347.6 ELR22727.1 - 3.3 6.1 14.3 0.13 10.8 6.2 1.9 1 1 1 2 2 2 0 MFS/sugar transport protein AMP-binding PF00501.28 ELR22728.1 - 3.1e-91 306.1 0.0 3.9e-91 305.8 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 ELR22728.1 - 2e-15 57.5 4.0 2.2e-14 54.2 4.0 2.5 1 1 0 1 1 1 1 AMP-binding enzyme C-terminal domain HxlR PF01638.17 ELR22728.1 - 0.15 11.9 0.1 1.3 8.9 0.1 2.2 2 0 0 2 2 2 0 HxlR-like helix-turn-helix Peptidase_S49_N PF08496.10 ELR22729.1 - 0.2 11.7 7.9 0.37 10.9 7.9 1.4 1 0 0 1 1 1 0 Peptidase family S49 N-terminal FAM199X PF15814.5 ELR22729.1 - 0.26 10.3 11.9 0.4 9.7 11.9 1.2 1 0 0 1 1 1 0 Protein family FAM199X SR-25 PF10500.9 ELR22729.1 - 6.9 6.2 26.6 17 5.0 26.6 1.7 1 1 0 1 1 1 0 Nuclear RNA-splicing-associated protein PBP1_TM PF14812.6 ELR22730.1 - 0.01 16.2 11.5 0.029 14.7 11.5 1.8 1 0 0 1 1 1 1 Transmembrane domain of transglycosylase PBP1 at N-terminal MFP2b PF12150.8 ELR22730.1 - 0.017 14.4 0.1 0.029 13.7 0.1 1.3 1 0 0 1 1 1 0 Cytosolic motility protein CDC45 PF02724.14 ELR22730.1 - 0.038 12.3 2.5 0.046 12.0 2.5 1.2 1 0 0 1 1 1 0 CDC45-like protein TFIIF_alpha PF05793.12 ELR22730.1 - 0.047 12.3 9.4 0.066 11.8 9.4 1.2 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) DUF4611 PF15387.6 ELR22730.1 - 0.11 12.7 6.9 0.35 11.1 6.9 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4611) Mastoparan_2 PF08251.11 ELR22730.1 - 1.7 9.0 7.7 4 7.9 0.3 2.9 2 0 0 2 2 2 0 Mastoparan peptide FAM176 PF14851.6 ELR22730.1 - 2.6 7.7 8.6 1.5 8.5 4.9 2.4 3 0 0 3 3 3 0 FAM176 family CENP-B_dimeris PF09026.10 ELR22730.1 - 3.8 7.9 12.3 7.6 7.0 12.3 1.4 1 0 0 1 1 1 0 Centromere protein B dimerisation domain YL1 PF05764.13 ELR22730.1 - 3.9 7.5 14.8 7.8 6.5 14.8 1.6 1 1 0 1 1 1 0 YL1 nuclear protein LZ_Tnp_IS66 PF13007.7 ELR22730.1 - 4.1 8.3 8.6 0.73 10.7 3.0 2.4 3 0 0 3 3 3 0 Transposase C of IS166 homeodomain Cwf_Cwc_15 PF04889.12 ELR22730.1 - 5.3 6.7 14.4 0.7 9.6 9.8 1.9 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein YL1 PF05764.13 ELR22731.1 - 0.00014 22.1 3.9 0.00014 22.1 3.9 2.6 2 1 0 2 2 2 1 YL1 nuclear protein CTU2 PF10288.9 ELR22731.1 - 0.0033 17.7 0.7 0.0033 17.7 0.7 2.8 3 0 0 3 3 3 1 Cytoplasmic tRNA 2-thiolation protein 2 DUF4611 PF15387.6 ELR22731.1 - 0.014 15.6 2.4 0.014 15.6 2.4 3.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4611) THOC2_N PF16134.5 ELR22731.1 - 0.072 11.7 10.9 0.18 10.4 3.2 2.3 2 0 0 2 2 2 0 THO complex subunit 2 N-terminus CDC45 PF02724.14 ELR22731.1 - 0.48 8.7 24.1 0.59 8.4 6.0 2.2 2 0 0 2 2 2 0 CDC45-like protein PBP1_TM PF14812.6 ELR22731.1 - 0.71 10.3 38.7 0.059 13.8 12.0 4.2 4 0 0 4 4 4 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DNA_pol_phi PF04931.13 ELR22731.1 - 1.1 7.3 17.0 0.031 12.4 2.9 2.2 2 0 0 2 2 2 0 DNA polymerase phi SpoIIP PF07454.11 ELR22731.1 - 1.2 8.5 10.5 8.1 5.8 5.5 2.4 2 0 0 2 2 2 0 Stage II sporulation protein P (SpoIIP) SIR2 PF02146.17 ELR22732.1 - 1.2e-05 25.4 0.2 1.3e-05 25.2 0.2 1.1 1 0 0 1 1 1 1 Sir2 family TPP_enzyme_M PF00205.22 ELR22732.1 - 0.019 14.7 0.0 0.022 14.5 0.0 1.1 1 0 0 1 1 1 0 Thiamine pyrophosphate enzyme, central domain SIR2 PF02146.17 ELR22733.1 - 5.2e-31 107.9 0.0 1.1e-30 106.9 0.0 1.6 1 1 0 1 1 1 1 Sir2 family TPP_enzyme_M PF00205.22 ELR22733.1 - 2e-06 27.6 0.0 0.012 15.4 0.0 2.2 2 0 0 2 2 2 2 Thiamine pyrophosphate enzyme, central domain Methyltransf_16 PF10294.9 ELR22734.1 - 6e-18 65.2 0.0 3.3e-13 49.7 0.0 2.3 2 0 0 2 2 2 2 Lysine methyltransferase DUF4589 PF15252.6 ELR22735.1 - 0.0041 17.2 0.4 0.0093 16.0 0.4 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4589) RRN3 PF05327.11 ELR22735.1 - 0.029 12.9 4.7 0.038 12.5 4.7 1.2 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Pinin_SDK_N PF04697.13 ELR22735.1 - 0.096 13.3 0.5 0.21 12.2 0.5 1.6 1 0 0 1 1 1 0 pinin/SDK conserved region Xpo1 PF08389.12 ELR22735.1 - 0.11 12.5 0.3 0.25 11.4 0.3 1.6 1 0 0 1 1 1 0 Exportin 1-like protein CLAG PF03805.13 ELR22735.1 - 0.16 9.5 0.1 0.21 9.1 0.1 1.1 1 0 0 1 1 1 0 Cytoadherence-linked asexual protein Tau95_N PF17682.1 ELR22735.1 - 0.86 9.8 2.9 1.1 9.4 0.1 2.5 3 1 0 3 3 3 0 Tau95 Triple barrel domain TPR_20 PF14561.6 ELR22736.1 - 4.8e-27 94.1 2.6 4.8e-27 94.1 2.6 2.9 2 1 0 2 2 2 1 Tetratricopeptide repeat Thioredoxin PF00085.20 ELR22736.1 - 1.5e-16 60.3 0.0 3.9e-14 52.5 0.0 2.5 1 1 1 2 2 2 1 Thioredoxin TPR_19 PF14559.6 ELR22736.1 - 3e-11 43.7 12.7 9.9e-06 26.0 4.2 2.9 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_16 PF13432.6 ELR22736.1 - 6.2e-06 26.8 8.4 0.0025 18.4 2.8 3.1 2 0 0 2 2 2 2 Tetratricopeptide repeat Thioredoxin_2 PF13098.6 ELR22736.1 - 0.00033 21.1 0.1 0.0022 18.4 0.1 2.2 1 1 0 1 1 1 1 Thioredoxin-like domain TPR_14 PF13428.6 ELR22736.1 - 0.00063 20.3 0.3 0.00063 20.3 0.3 3.7 4 0 0 4 4 2 1 Tetratricopeptide repeat TPR_MalT PF17874.1 ELR22736.1 - 0.0034 16.8 10.2 0.0083 15.5 10.2 1.6 1 1 0 1 1 1 1 MalT-like TPR region TPR_2 PF07719.17 ELR22736.1 - 0.0042 17.1 10.6 0.72 10.1 0.9 3.7 3 0 0 3 3 3 2 Tetratricopeptide repeat Thioredoxin_8 PF13905.6 ELR22736.1 - 0.015 15.6 0.1 0.075 13.4 0.0 2.2 2 1 1 3 3 3 0 Thioredoxin-like ANAPC3 PF12895.7 ELR22736.1 - 0.031 14.5 7.0 0.038 14.2 0.1 2.6 2 1 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 SPO22 PF08631.10 ELR22736.1 - 0.031 13.7 2.7 0.12 11.8 2.6 2.0 1 1 0 1 1 1 0 Meiosis protein SPO22/ZIP4 like TPR_11 PF13414.6 ELR22736.1 - 0.046 13.4 2.4 2.6 7.8 0.7 2.7 2 0 0 2 2 2 0 TPR repeat Filo_VP35 PF02097.15 ELR22736.1 - 0.05 12.7 1.2 0.11 11.6 0.1 1.9 2 0 0 2 2 2 0 Filoviridae VP35 Thioredoxin_7 PF13899.6 ELR22736.1 - 0.11 12.7 0.0 0.28 11.4 0.0 1.7 1 0 0 1 1 1 0 Thioredoxin-like TPR_4 PF07721.14 ELR22736.1 - 0.24 12.2 0.2 0.24 12.2 0.2 3.9 4 1 0 4 4 3 0 Tetratricopeptide repeat Glyco_trans_1_2 PF13524.6 ELR22736.1 - 0.57 10.6 3.5 0.45 10.9 0.2 2.4 2 2 1 3 3 2 0 Glycosyl transferases group 1 TPR_8 PF13181.6 ELR22736.1 - 0.58 10.5 0.0 0.58 10.5 0.0 3.0 4 0 0 4 4 3 0 Tetratricopeptide repeat TPR_12 PF13424.6 ELR22736.1 - 0.87 9.9 10.2 9.3 6.6 3.4 3.5 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_1 PF00515.28 ELR22736.1 - 1.4 8.9 7.6 1.4 8.9 0.0 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_6 PF13174.6 ELR22736.1 - 2.4 9.0 7.1 4 8.3 0.1 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat HemY_N PF07219.13 ELR22736.1 - 4.1 7.7 6.1 0.94 9.7 1.7 2.2 1 1 1 2 2 2 0 HemY protein N-terminus CUE PF02845.16 ELR22737.1 - 3.7e-11 42.5 0.9 1.8e-09 37.1 0.1 2.4 2 0 0 2 2 2 2 CUE domain Lipocalin_2 PF08212.12 ELR22737.1 - 0.11 12.4 0.0 0.23 11.4 0.0 1.5 1 0 0 1 1 1 0 Lipocalin-like domain Ank_4 PF13637.6 ELR22738.1 - 3.1e-12 46.8 0.0 7.1e-09 36.0 0.0 2.7 3 0 0 3 3 3 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 ELR22738.1 - 2.1e-11 44.2 0.0 2.7e-10 40.7 0.0 2.3 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 ELR22738.1 - 4.9e-11 42.6 0.4 4.9e-05 23.5 0.0 3.8 3 1 1 4 4 4 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 ELR22738.1 - 8.5e-10 38.0 0.0 0.012 16.1 0.0 4.0 4 0 0 4 4 4 2 Ankyrin repeat Ank PF00023.30 ELR22738.1 - 3.7e-08 33.5 0.0 0.032 14.7 0.0 3.7 4 0 0 4 4 4 2 Ankyrin repeat TruB_C PF09142.11 ELR22738.1 - 0.35 10.7 4.8 5.1 7.0 0.6 2.5 2 0 0 2 2 2 0 tRNA Pseudouridine synthase II, C terminal HHV-1_VABD PF16852.5 ELR22738.1 - 0.49 10.4 6.8 2.6 8.1 0.2 3.1 3 0 0 3 3 3 0 Herpes viral adaptor-to-host cellular mRNA binding domain Cellulase PF00150.18 ELR22742.1 - 9.8e-17 61.3 7.8 1.4e-16 60.7 7.8 1.2 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) Glyco_hydro_2_C PF02836.17 ELR22742.1 - 0.013 14.6 0.1 0.022 13.9 0.1 1.3 1 0 0 1 1 1 0 Glycosyl hydrolases family 2, TIM barrel domain NapE PF06796.11 ELR22743.1 - 0.026 14.0 0.5 0.055 13.0 0.5 1.5 1 0 0 1 1 1 0 Periplasmic nitrate reductase protein NapE DUF3938 PF13074.6 ELR22743.1 - 0.048 13.9 0.8 1.5 9.2 0.2 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3938) Methyltrans_SAM PF10672.9 ELR22744.1 - 3.6e-15 55.9 0.0 5.3e-15 55.3 0.0 1.1 1 0 0 1 1 1 1 S-adenosylmethionine-dependent methyltransferase Methyltransf_31 PF13847.6 ELR22744.1 - 3.9e-12 46.2 0.0 6e-12 45.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ELR22744.1 - 1.1e-11 45.2 0.1 2.8e-11 44.0 0.1 1.7 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 ELR22744.1 - 2.4e-10 40.2 0.0 4.2e-10 39.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain PrmA PF06325.13 ELR22744.1 - 1.4e-09 37.8 0.0 7.1e-09 35.5 0.0 2.0 2 0 0 2 2 2 1 Ribosomal protein L11 methyltransferase (PrmA) FtsJ PF01728.19 ELR22744.1 - 1.6e-09 38.1 0.0 3.4e-09 37.1 0.0 1.5 2 0 0 2 2 1 1 FtsJ-like methyltransferase Cons_hypoth95 PF03602.15 ELR22744.1 - 9.2e-08 31.9 0.0 1.6e-07 31.2 0.0 1.3 1 0 0 1 1 1 1 Conserved hypothetical protein 95 Methyltransf_15 PF09445.10 ELR22744.1 - 3.6e-07 29.9 0.0 6.4e-07 29.1 0.0 1.4 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase Met_10 PF02475.16 ELR22744.1 - 3e-06 27.1 0.0 5.8e-06 26.2 0.0 1.4 1 0 0 1 1 1 1 Met-10+ like-protein Methyltransf_11 PF08241.12 ELR22744.1 - 4.5e-06 27.2 0.0 1.3e-05 25.8 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain Methyltr_RsmB-F PF01189.17 ELR22744.1 - 8.5e-06 25.5 0.1 9.4e-05 22.1 0.1 2.1 1 1 0 1 1 1 1 16S rRNA methyltransferase RsmB/F Methyltransf_23 PF13489.6 ELR22744.1 - 2.5e-05 24.2 0.1 8.6e-05 22.4 0.1 2.0 2 1 0 2 2 2 1 Methyltransferase domain PUA_3 PF17785.1 ELR22744.1 - 6.1e-05 22.7 0.0 0.00013 21.7 0.0 1.6 1 0 0 1 1 1 1 PUA-like domain Methyltransf_18 PF12847.7 ELR22744.1 - 0.00011 22.1 0.0 0.0002 21.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ELR22744.1 - 0.0005 20.8 0.0 0.0017 19.1 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_10 PF05971.12 ELR22744.1 - 0.0011 18.4 0.0 0.0016 17.8 0.0 1.2 1 0 0 1 1 1 1 RNA methyltransferase UPF0020 PF01170.18 ELR22744.1 - 0.0012 18.6 0.2 0.0055 16.4 0.2 2.0 1 1 0 1 1 1 1 Putative RNA methylase family UPF0020 Ubie_methyltran PF01209.18 ELR22744.1 - 0.0055 16.1 0.0 0.01 15.2 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family DUF43 PF01861.16 ELR22744.1 - 0.031 13.5 0.0 0.053 12.7 0.0 1.3 1 0 0 1 1 1 0 Branched-chain polyamine synthase A C-terminal domain Pox_MCEL PF03291.16 ELR22744.1 - 0.031 13.4 0.0 0.05 12.7 0.0 1.3 1 0 0 1 1 1 0 mRNA capping enzyme DNA_methylase PF00145.17 ELR22744.1 - 0.037 13.4 0.0 0.052 12.9 0.0 1.2 1 0 0 1 1 1 0 C-5 cytosine-specific DNA methylase Spermine_synth PF01564.17 ELR22744.1 - 0.13 11.6 0.0 0.2 11.1 0.0 1.3 1 0 0 1 1 1 0 Spermine/spermidine synthase domain tRNA_U5-meth_tr PF05958.11 ELR22744.1 - 0.15 11.0 0.0 0.25 10.3 0.0 1.3 1 0 0 1 1 1 0 tRNA (Uracil-5-)-methyltransferase Glyco_hydro_31 PF01055.26 ELR22745.1 - 1.2e-08 34.6 0.0 1.8e-08 34.0 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 Ecm33 PF12454.8 ELR22745.1 - 0.035 14.2 0.4 0.035 14.2 0.4 1.8 2 0 0 2 2 2 0 GPI-anchored cell wall organization protein Arm PF00514.23 ELR22746.1 - 5.2 7.3 7.6 4.1 7.6 0.0 4.3 6 0 0 6 6 6 0 Armadillo/beta-catenin-like repeat GATA PF00320.27 ELR22747.1 - 1.6e-06 27.6 9.6 1.6e-06 27.6 9.6 2.4 2 0 0 2 2 2 1 GATA zinc finger CTU2 PF10288.9 ELR22747.1 - 2.2 8.5 10.4 5.5 7.3 7.4 2.4 2 1 0 2 2 2 0 Cytoplasmic tRNA 2-thiolation protein 2 zf-MYND PF01753.18 ELR22748.1 - 2.2e-08 34.1 12.4 4.7e-08 33.0 12.4 1.6 1 0 0 1 1 1 1 MYND finger Rdx PF10262.9 ELR22749.1 - 7.1e-06 26.1 0.0 8.8e-06 25.8 0.0 1.1 1 0 0 1 1 1 1 Rdx family Methyltransf_11 PF08241.12 ELR22750.1 - 1.2e-10 41.9 0.0 2.1e-06 28.3 0.0 2.3 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_25 PF13649.6 ELR22750.1 - 4.2e-10 40.2 0.0 0.00043 20.9 0.0 2.3 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_31 PF13847.6 ELR22750.1 - 1.5e-08 34.6 0.0 0.0054 16.5 0.0 2.2 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_12 PF08242.12 ELR22750.1 - 6.8e-07 30.0 0.0 2.2e-06 28.3 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 ELR22750.1 - 0.0012 18.4 0.0 0.98 8.9 0.0 2.1 2 0 0 2 2 2 2 Methyltransferase small domain Methyltransf_32 PF13679.6 ELR22750.1 - 0.065 13.2 0.0 0.099 12.6 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain Inositol_P PF00459.25 ELR22751.1 - 9.2e-44 150.0 0.9 2.7e-32 112.4 0.2 2.1 1 1 1 2 2 2 2 Inositol monophosphatase family Pkinase PF00069.25 ELR22752.1 - 5.1e-65 219.5 0.0 1.2e-64 218.3 0.0 1.6 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR22752.1 - 5.2e-33 114.4 0.0 1.3e-32 113.1 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase PH PF00169.29 ELR22752.1 - 1.1e-15 58.0 0.0 2.2e-15 57.0 0.0 1.5 1 0 0 1 1 1 1 PH domain PH_11 PF15413.6 ELR22752.1 - 1.1e-05 25.8 0.1 2.1e-05 24.9 0.1 1.5 1 0 0 1 1 1 1 Pleckstrin homology domain Kinase-like PF14531.6 ELR22752.1 - 0.0012 18.2 0.0 0.0054 16.1 0.0 1.9 2 0 0 2 2 2 1 Kinase-like PH_3 PF14593.6 ELR22752.1 - 0.0051 16.9 0.1 0.031 14.4 0.1 2.2 2 1 0 2 2 2 1 PH domain FTA2 PF13095.6 ELR22752.1 - 0.017 14.7 0.0 2.1 7.9 0.0 2.4 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 DUF3899 PF13038.6 ELR22753.1 - 0.23 12.0 0.1 0.92 10.1 0.1 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF3899) Sas10 PF09368.10 ELR22754.1 - 3.5e-25 88.3 7.7 3.5e-25 88.3 7.7 2.1 1 1 1 2 2 2 1 Sas10 C-terminal domain CLTH PF10607.9 ELR22755.1 - 2.6e-32 111.7 0.1 3.6e-32 111.3 0.1 1.2 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain LisH PF08513.11 ELR22755.1 - 3.8e-06 26.6 0.1 8.9e-05 22.3 0.1 2.3 2 0 0 2 2 2 1 LisH NUDIX-like PF09296.11 ELR22755.1 - 0.033 14.9 0.2 0.066 13.9 0.1 1.6 1 1 0 1 1 1 0 NADH pyrophosphatase-like rudimentary NUDIX domain Neuregulin PF02158.15 ELR22755.1 - 0.59 9.4 10.3 0.68 9.2 10.3 1.2 1 0 0 1 1 1 0 Neuregulin intracellular region Peptidase_S8 PF00082.22 ELR22756.1 - 1.3e-70 238.0 0.0 2e-68 230.9 0.0 2.4 1 1 0 1 1 1 1 Subtilase family TPPII PF12580.8 ELR22756.1 - 1.6e-58 197.3 0.0 3e-58 196.4 0.0 1.4 1 0 0 1 1 1 1 Tripeptidyl peptidase II GlutR_dimer PF00745.20 ELR22756.1 - 1.8 9.1 9.7 4.5 7.8 0.3 3.3 3 0 0 3 3 3 0 Glutamyl-tRNAGlu reductase, dimerisation domain SR-25 PF10500.9 ELR22756.1 - 2.6 7.6 10.0 0.073 12.7 2.6 2.0 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein zf-Mss51 PF13824.6 ELR22757.1 - 0.00015 21.8 5.6 0.00042 20.3 5.6 1.8 1 1 0 1 1 1 1 Zinc-finger of mitochondrial splicing suppressor 51 zf-MYND PF01753.18 ELR22757.1 - 0.023 14.8 8.7 0.023 14.8 8.7 1.9 2 1 0 2 2 2 0 MYND finger Env-gp36 PF09590.10 ELR22757.1 - 0.057 11.8 0.0 0.064 11.7 0.0 1.1 1 0 0 1 1 1 0 Lentivirus surface glycoprotein P21-Arc PF04062.14 ELR22758.1 - 9.3e-65 217.9 0.0 1e-64 217.8 0.0 1.0 1 0 0 1 1 1 1 ARP2/3 complex ARPC3 (21 kDa) subunit Hormone_3 PF00159.18 ELR22758.1 - 0.045 13.8 0.1 0.08 13.0 0.1 1.4 1 0 0 1 1 1 0 Pancreatic hormone peptide MA3 PF02847.17 ELR22759.1 - 2.7e-29 101.4 1.9 4.9e-29 100.6 1.1 1.9 2 0 0 2 2 2 1 MA3 domain MIF4G PF02854.19 ELR22759.1 - 1.3e-15 57.7 0.2 3.2e-15 56.3 0.0 1.8 2 0 0 2 2 2 1 MIF4G domain RNA_pol_Rpc4 PF05132.14 ELR22759.1 - 4.5 7.7 10.5 9.7 6.6 3.5 2.3 2 0 0 2 2 2 0 RNA polymerase III RPC4 Zip PF02535.22 ELR22759.1 - 9 5.4 7.4 1 8.5 2.7 1.7 2 0 0 2 2 2 0 ZIP Zinc transporter Ank_2 PF12796.7 ELR22761.1 - 1.6e-54 182.4 22.6 3.8e-16 59.4 0.9 4.5 1 1 3 5 5 5 5 Ankyrin repeats (3 copies) Ank PF00023.30 ELR22761.1 - 1.2e-41 139.4 12.9 1.3e-05 25.4 1.3 8.4 8 0 0 8 8 8 8 Ankyrin repeat Ank_4 PF13637.6 ELR22761.1 - 2.7e-40 136.2 3.9 1.6e-08 34.9 0.0 6.5 3 2 3 6 6 6 6 Ankyrin repeats (many copies) Ank_5 PF13857.6 ELR22761.1 - 5.9e-37 125.3 10.9 2e-10 40.7 0.0 6.2 2 1 2 6 6 6 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 ELR22761.1 - 8.1e-33 108.8 3.3 0.0052 17.2 0.0 9.1 9 0 0 9 9 9 6 Ankyrin repeat F-box-like PF12937.7 ELR22761.1 - 2.1e-08 33.9 0.2 3.7e-08 33.1 0.2 1.4 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ELR22761.1 - 0.0057 16.5 0.8 0.054 13.4 0.8 2.2 1 1 0 1 1 1 1 F-box domain YlzJ PF14035.6 ELR22761.1 - 0.015 15.5 0.0 7.8 6.8 0.0 3.9 3 1 1 4 4 4 0 YlzJ-like protein DUF2833 PF11090.8 ELR22761.1 - 0.045 14.1 0.3 0.11 12.9 0.3 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2833) TFIIA PF03153.13 ELR22761.1 - 0.05 13.6 14.8 0.092 12.7 14.8 1.5 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Elongin_A PF06881.11 ELR22761.1 - 3.1 8.4 10.7 0.15 12.6 0.9 2.5 2 0 0 2 2 2 0 RNA polymerase II transcription factor SIII (Elongin) subunit A Cyclin_N PF00134.23 ELR22762.1 - 2e-10 40.5 0.1 3.5e-10 39.7 0.1 1.4 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin PF08613.11 ELR22762.1 - 0.00055 20.3 0.3 0.00073 19.9 0.3 1.3 1 1 0 1 1 1 1 Cyclin MAPEG PF01124.18 ELR22763.1 - 5.2e-16 58.7 2.7 6.2e-16 58.5 2.7 1.1 1 0 0 1 1 1 1 MAPEG family DUF4209 PF13910.6 ELR22764.1 - 1.1e-19 70.4 0.0 4.4e-15 55.7 0.0 2.7 2 0 0 2 2 2 2 Domain of unknown function (DUF4209) GATA PF00320.27 ELR22765.1 - 3.9e-13 48.8 6.8 7.9e-13 47.8 6.8 1.6 1 0 0 1 1 1 1 GATA zinc finger Zn_Tnp_IS91 PF14319.6 ELR22765.1 - 0.097 12.7 1.0 0.18 11.8 1.0 1.5 1 0 0 1 1 1 0 Transposase zinc-binding domain DZR PF12773.7 ELR22765.1 - 3.4 7.8 8.7 16 5.6 8.7 2.2 1 1 0 1 1 1 0 Double zinc ribbon Rubredoxin_2 PF18073.1 ELR22765.1 - 6.6 6.6 7.5 9.4 6.1 3.1 2.4 2 0 0 2 2 2 0 Rubredoxin metal binding domain IGFBP PF00219.18 ELR22766.1 - 3.1 8.5 10.4 5.9 7.6 10.4 1.5 1 0 0 1 1 1 0 Insulin-like growth factor binding protein CTP_transf_1 PF01148.20 ELR22767.1 - 1.7e-43 149.3 8.0 2.9e-43 148.6 8.0 1.3 1 1 0 1 1 1 1 Cytidylyltransferase family Shisa PF13908.6 ELR22767.1 - 0.23 11.7 0.0 0.58 10.4 0.0 1.6 2 0 0 2 2 2 0 Wnt and FGF inhibitory regulator DUF4131 PF13567.6 ELR22767.1 - 1.1 8.9 4.4 2.4 7.8 2.9 2.2 1 1 2 3 3 3 0 Domain of unknown function (DUF4131) CDP-OH_P_transf PF01066.21 ELR22768.1 - 1.1e-11 45.3 0.4 1.1e-11 45.3 0.4 2.8 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase Rib_5-P_isom_A PF06026.14 ELR22770.1 - 5.2e-60 202.0 0.0 7.1e-60 201.5 0.0 1.2 1 0 0 1 1 1 1 Ribose 5-phosphate isomerase A (phosphoriboisomerase A) CTU2 PF10288.9 ELR22771.1 - 6.4e-07 29.6 0.7 6.1e-05 23.2 0.0 3.3 2 1 0 2 2 2 1 Cytoplasmic tRNA 2-thiolation protein 2 SecY PF00344.20 ELR22772.1 - 2.2e-73 247.2 10.2 2.8e-73 246.9 10.2 1.1 1 0 0 1 1 1 1 SecY translocase Plug_translocon PF10559.9 ELR22772.1 - 5.2e-19 67.8 2.6 5.7e-19 67.7 0.2 2.4 2 0 0 2 2 2 1 Plug domain of Sec61p Filamin PF00630.19 ELR22773.1 - 3.7e-71 236.5 0.7 3.8e-19 69.4 0.1 5.7 6 0 0 6 6 6 5 Filamin/ABP280 repeat Lectin_legB PF00139.19 ELR22773.1 - 7.4e-16 58.4 0.2 1.6e-15 57.4 0.2 1.5 1 0 0 1 1 1 1 Legume lectin domain Invasin_D3 PF09134.10 ELR22773.1 - 2.7e-10 40.4 17.2 0.00011 22.4 0.4 5.4 5 0 0 5 5 5 3 Invasin, domain 3 Laminin_G_2 PF02210.24 ELR22773.1 - 0.0029 18.2 0.0 0.0068 17.0 0.0 1.6 1 0 0 1 1 1 1 Laminin G domain CopC PF04234.12 ELR22773.1 - 0.0092 17.0 1.4 8.4 7.5 0.0 3.8 3 0 0 3 3 3 1 CopC domain YtkA PF13115.6 ELR22773.1 - 0.031 14.9 10.2 3.9 8.2 0.2 4.8 5 0 0 5 5 5 0 YtkA-like MG2 PF01835.19 ELR22773.1 - 0.038 14.4 3.7 2.8 8.5 0.2 4.5 6 0 0 6 6 6 0 MG2 domain bMG6 PF17962.1 ELR22773.1 - 0.11 12.6 2.0 5.4 7.2 0.0 3.4 4 0 0 4 4 4 0 Bacterial macroglobulin domain 6 BatA PF07584.11 ELR22773.1 - 2.2 8.7 5.1 48 4.4 0.0 2.4 2 0 0 2 2 2 0 Aerotolerance regulator N-terminal EphA2_TM PF14575.6 ELR22773.1 - 3.9 8.4 5.1 7 7.6 2.2 2.4 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain Big_6 PF17936.1 ELR22773.1 - 5.4 7.4 21.9 3.4 8.0 0.1 7.6 7 2 3 10 10 10 0 Bacterial Ig domain RL10P_insert PF17777.1 ELR22774.1 - 1.3e-27 95.5 0.0 2e-27 95.0 0.0 1.3 1 0 0 1 1 1 1 Insertion domain in 60S ribosomal protein L10P Ribosomal_L10 PF00466.20 ELR22774.1 - 3.4e-21 75.3 0.0 4.9e-21 74.8 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L10 DUF2385 PF09539.10 ELR22774.1 - 0.0026 18.2 0.0 0.061 13.9 0.1 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF2385) Rax2 PF12768.7 ELR22775.1 - 0.094 12.2 0.2 0.17 11.4 0.0 1.5 2 0 0 2 2 2 0 Cortical protein marker for cell polarity MLANA PF14991.6 ELR22775.1 - 0.2 11.9 0.0 0.43 10.9 0.0 1.6 1 0 0 1 1 1 0 Protein melan-A G3P_acyltransf PF02660.15 ELR22775.1 - 0.87 9.6 3.6 0.4 10.7 0.5 1.9 2 0 0 2 2 2 0 Glycerol-3-phosphate acyltransferase DUF2946 PF11162.8 ELR22775.1 - 4.1 8.1 8.9 1.3 9.8 4.7 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF2946) BatA PF07584.11 ELR22775.1 - 7.9 6.9 6.7 0.5 10.8 0.3 2.1 2 0 0 2 2 2 0 Aerotolerance regulator N-terminal CPP1-like PF11833.8 ELR22776.1 - 3.6 7.2 4.8 0.96 9.1 0.1 2.0 2 0 0 2 2 2 0 Protein CHAPERONE-LIKE PROTEIN OF POR1-like EF_TS PF00889.19 ELR22777.1 - 1.3e-14 54.3 0.0 9.9e-12 44.9 0.0 2.1 1 1 1 2 2 2 2 Elongation factor TS CtnDOT_TraJ PF07863.11 ELR22777.1 - 5.1 7.8 7.0 1.4 9.6 2.8 2.3 2 0 0 2 2 2 0 Homologues of TraJ from Bacteroides conjugative transposon LSM PF01423.22 ELR22778.1 - 3.3e-19 68.3 0.2 5e-19 67.8 0.2 1.2 1 0 0 1 1 1 1 LSM domain Hfq PF17209.3 ELR22778.1 - 0.011 15.3 0.1 0.019 14.6 0.1 1.4 1 0 0 1 1 1 0 Hfq protein DUF3556 PF12077.8 ELR22779.1 - 0.022 13.2 1.0 0.026 13.0 1.0 1.1 1 0 0 1 1 1 0 Transmembrane protein of unknown function (DUF3556) Presenilin PF01080.17 ELR22779.1 - 0.37 9.5 3.6 0.45 9.2 3.6 1.1 1 0 0 1 1 1 0 Presenilin bZIP_1 PF00170.21 ELR22780.1 - 1.3e-12 47.6 5.8 2.7e-12 46.6 5.8 1.6 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 ELR22780.1 - 1e-07 31.9 5.7 1e-07 31.9 5.7 1.8 2 0 0 2 2 2 1 Basic region leucine zipper bZIP_Maf PF03131.17 ELR22780.1 - 6.8 7.3 15.7 0.4 11.2 8.3 2.2 2 0 0 2 2 2 0 bZIP Maf transcription factor CEP63 PF17045.5 ELR22780.1 - 8.9 6.1 9.8 0.14 12.1 2.3 1.6 2 0 0 2 2 2 0 Centrosomal protein of 63 kDa Retinin_C PF04527.12 ELR22781.1 - 0.077 13.3 0.5 0.14 12.5 0.5 1.3 1 0 0 1 1 1 0 Drosophila Retinin like protein DHHC PF01529.20 ELR22782.1 - 3e-29 101.8 5.7 3e-29 101.8 5.7 1.7 2 0 0 2 2 2 1 DHHC palmitoyltransferase WD40 PF00400.32 ELR22783.1 - 9.2e-31 105.4 22.4 2.5e-08 34.4 0.0 8.2 8 1 0 8 8 8 5 WD domain, G-beta repeat Hira PF07569.11 ELR22783.1 - 8.1e-19 68.2 6.7 4.8e-13 49.3 2.4 3.1 1 1 1 2 2 2 2 TUP1-like enhancer of split ANAPC4_WD40 PF12894.7 ELR22783.1 - 1.6e-11 44.3 0.1 0.23 11.8 0.0 5.7 5 1 1 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain HIRA_B PF09453.10 ELR22783.1 - 3.7e-09 36.2 0.5 0.00011 22.0 0.0 3.0 2 0 0 2 2 2 2 HIRA B motif PD40 PF07676.12 ELR22783.1 - 9.7e-07 28.6 2.8 0.37 10.8 0.0 4.6 4 0 0 4 4 4 2 WD40-like Beta Propeller Repeat WD40_like PF17005.5 ELR22783.1 - 0.0013 18.1 0.0 0.82 8.9 0.0 2.2 2 0 0 2 2 2 2 WD40-like domain Ge1_WD40 PF16529.5 ELR22783.1 - 0.0025 16.8 0.0 1.4 7.8 0.0 3.2 3 1 1 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Presenilin PF01080.17 ELR22783.1 - 4.1 6.1 4.9 6.6 5.4 4.9 1.3 1 0 0 1 1 1 0 Presenilin WD40 PF00400.32 ELR22784.1 - 9.8e-18 64.2 14.4 7.3e-05 23.5 0.2 6.7 7 0 0 7 7 7 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ELR22784.1 - 1.1e-08 35.2 1.4 0.13 12.5 0.0 4.2 2 1 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ELR22784.1 - 4.9e-05 22.5 0.5 0.086 11.8 0.2 3.8 2 1 0 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Synaphin PF05835.12 ELR22784.1 - 5.2e-05 23.6 2.4 8e-05 22.9 2.4 1.2 1 0 0 1 1 1 1 Synaphin protein eIF2A PF08662.11 ELR22784.1 - 0.00023 21.1 0.0 0.58 10.0 0.0 2.4 1 1 0 2 2 2 2 Eukaryotic translation initiation factor eIF2A GTP_EFTU_D3 PF03143.17 ELR22785.1 - 7.5e-33 113.2 0.1 1.8e-32 112.0 0.1 1.6 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU PF00009.27 ELR22785.1 - 2.7e-25 89.1 0.0 4.7e-25 88.3 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain CBS PF00571.28 ELR22785.1 - 5.9e-25 87.5 10.4 9.5e-09 35.6 0.0 5.0 5 0 0 5 5 5 4 CBS domain GTP_EFTU_D2 PF03144.25 ELR22785.1 - 7.7e-08 32.6 0.6 3.9e-07 30.4 0.6 2.3 2 0 0 2 2 2 1 Elongation factor Tu domain 2 PAM2 PF07145.15 ELR22785.1 - 0.094 12.4 12.0 0.21 11.4 3.8 2.4 1 1 1 2 2 2 0 Ataxin-2 C-terminal region Mod_r PF07200.13 ELR22786.1 - 4.5e-26 91.7 9.7 5.2e-26 91.5 9.7 1.0 1 0 0 1 1 1 1 Modifier of rudimentary (Mod(r)) protein TolA_bind_tri PF16331.5 ELR22786.1 - 0.1 12.7 6.4 0.075 13.1 3.4 2.1 1 1 1 2 2 2 0 TolA binding protein trimerisation Rap_GAP PF02145.15 ELR22787.1 - 1.1e-30 106.5 0.0 1.4e-22 80.2 0.0 2.2 1 1 1 2 2 2 2 Rap/ran-GAP TPR_2 PF07719.17 ELR22792.1 - 2.6e-31 105.2 17.3 3.2e-06 26.8 0.0 8.5 8 0 0 8 8 8 6 Tetratricopeptide repeat TPR_1 PF00515.28 ELR22792.1 - 4.6e-26 89.5 11.5 9.9e-08 31.5 0.0 7.8 8 0 0 8 8 8 6 Tetratricopeptide repeat TPR_16 PF13432.6 ELR22792.1 - 1.1e-19 70.7 32.9 6.9e-07 29.8 0.7 5.5 5 1 0 5 5 5 4 Tetratricopeptide repeat TPR_14 PF13428.6 ELR22792.1 - 9.4e-18 63.4 31.1 0.017 15.9 0.0 8.8 5 2 4 9 9 8 5 Tetratricopeptide repeat TPR_8 PF13181.6 ELR22792.1 - 1.1e-17 62.7 5.9 8.7e-05 22.4 0.0 7.2 8 0 0 8 8 8 3 Tetratricopeptide repeat TPR_12 PF13424.6 ELR22792.1 - 1.9e-17 63.3 8.2 2.9e-11 43.5 0.6 6.7 5 2 3 8 8 8 5 Tetratricopeptide repeat TPR_11 PF13414.6 ELR22792.1 - 4.7e-16 58.2 3.5 6.5e-06 25.7 0.0 7.0 5 2 2 7 7 7 3 TPR repeat TPR_7 PF13176.6 ELR22792.1 - 3.5e-12 45.4 9.3 2.7e-07 30.1 0.0 5.8 4 1 1 5 5 5 2 Tetratricopeptide repeat TPR_10 PF13374.6 ELR22792.1 - 7.1e-11 41.6 14.3 7.1e-06 25.7 0.1 6.2 8 0 0 8 8 7 2 Tetratricopeptide repeat TPR_19 PF14559.6 ELR22792.1 - 5e-07 30.1 22.0 0.14 12.7 0.3 6.8 6 1 1 7 7 7 2 Tetratricopeptide repeat TPR_6 PF13174.6 ELR22792.1 - 0.00012 22.5 18.0 0.3 11.8 0.0 6.7 7 1 0 7 7 6 1 Tetratricopeptide repeat TPR_17 PF13431.6 ELR22792.1 - 0.00024 21.3 18.2 3.3 8.3 0.1 7.8 9 0 0 9 9 8 1 Tetratricopeptide repeat DUF3856 PF12968.7 ELR22792.1 - 0.0013 18.8 1.7 1.7 8.7 0.2 2.8 2 1 0 2 2 2 2 Domain of Unknown Function (DUF3856) TPR_4 PF07721.14 ELR22792.1 - 0.004 17.6 0.3 0.18 12.5 0.1 8.6 9 0 0 9 9 8 2 Tetratricopeptide repeat SNAP PF14938.6 ELR22792.1 - 0.0084 15.6 1.2 0.078 12.4 0.1 2.4 1 1 0 2 2 2 1 Soluble NSF attachment protein, SNAP ANAPC3 PF12895.7 ELR22792.1 - 0.013 15.7 14.8 0.57 10.5 0.9 4.3 3 1 0 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_21 PF09976.9 ELR22792.1 - 0.013 15.2 7.0 3.9 7.1 0.1 4.2 2 1 2 4 4 4 0 Tetratricopeptide repeat-like domain TPR_9 PF13371.6 ELR22792.1 - 0.061 13.5 17.1 1 9.5 0.4 5.1 4 2 0 4 4 4 0 Tetratricopeptide repeat RPN7 PF10602.9 ELR22792.1 - 0.069 12.9 0.7 43 3.8 0.0 3.3 1 1 2 3 3 3 0 26S proteasome subunit RPN7 TPR_3 PF07720.12 ELR22792.1 - 4.3 7.4 6.9 23 5.1 0.1 3.8 3 0 0 3 3 3 0 Tetratricopeptide repeat DNA_mis_repair PF01119.19 ELR22793.1 - 2e-15 56.5 0.0 3.2e-15 55.8 0.0 1.3 1 0 0 1 1 1 1 DNA mismatch repair protein, C-terminal domain Img2 PF05046.14 ELR22794.1 - 3.9e-21 75.1 0.0 4.6e-21 74.9 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial large subunit ribosomal protein (Img2) Thioredoxin PF00085.20 ELR22795.1 - 1.4e-56 188.9 0.0 6.9e-30 103.1 0.0 2.2 2 0 0 2 2 2 2 Thioredoxin Thioredoxin_2 PF13098.6 ELR22795.1 - 3.3e-08 33.9 0.1 0.0018 18.7 0.0 3.1 2 2 0 2 2 2 2 Thioredoxin-like domain Thioredoxin_7 PF13899.6 ELR22795.1 - 9.1e-07 29.0 0.0 0.058 13.6 0.0 2.4 2 0 0 2 2 2 2 Thioredoxin-like DDE_Tnp_1_2 PF13586.6 ELR22795.1 - 0.00013 22.3 0.0 0.65 10.4 0.0 2.4 2 0 0 2 2 2 2 Transposase DDE domain TraF PF13728.6 ELR22795.1 - 0.0002 21.3 0.0 0.17 11.6 0.0 2.6 2 1 1 3 3 3 2 F plasmid transfer operon protein Thioredoxin_3 PF13192.6 ELR22795.1 - 0.00035 20.6 0.0 1.1 9.4 0.0 2.4 2 0 0 2 2 2 2 Thioredoxin domain Thioredoxin_8 PF13905.6 ELR22795.1 - 0.00073 19.8 0.0 7 7.1 0.0 3.7 2 2 2 4 4 4 2 Thioredoxin-like Thioredoxin_9 PF14595.6 ELR22795.1 - 0.00086 19.1 0.1 0.47 10.2 0.1 2.5 2 1 0 2 2 2 2 Thioredoxin Glutaredoxin PF00462.24 ELR22795.1 - 0.0068 16.6 0.0 0.92 9.8 0.0 2.6 2 0 0 2 2 2 1 Glutaredoxin MT-A70 PF05063.14 ELR22796.1 - 2.7e-20 73.0 0.0 3.6e-20 72.6 0.0 1.2 1 0 0 1 1 1 1 MT-A70 hSac2 PF12456.8 ELR22797.1 - 3.7e-12 46.0 0.0 7.2e-12 45.0 0.0 1.4 1 0 0 1 1 1 1 Inositol phosphatase RhoGAP PF00620.27 ELR22798.1 - 2e-24 86.1 0.0 4.9e-24 84.9 0.0 1.7 1 0 0 1 1 1 1 RhoGAP domain SH2 PF00017.24 ELR22798.1 - 2.1e-20 72.6 0.0 2.1e-09 37.3 0.0 2.4 2 0 0 2 2 2 2 SH2 domain RasGEF_N PF00618.20 ELR22798.1 - 2.5e-11 43.7 0.0 8.2e-11 42.1 0.0 2.0 1 0 0 1 1 1 1 RasGEF N-terminal motif Cbl_N2 PF02761.14 ELR22798.1 - 4.3e-06 27.3 0.1 1.6e-05 25.5 0.1 1.9 2 0 0 2 2 2 1 CBL proto-oncogene N-terminus, EF hand-like domain Cbl_N3 PF02762.14 ELR22798.1 - 0.029 14.2 0.0 6.9 6.6 0.0 2.6 2 0 0 2 2 2 0 CBL proto-oncogene N-terminus, SH2-like domain EF-hand_6 PF13405.6 ELR22798.1 - 0.31 11.1 1.4 3.8 7.7 0.0 3.4 4 0 0 4 4 4 0 EF-hand domain RasGEF PF00617.19 ELR22799.1 - 1.1e-46 159.3 0.0 1.5e-46 158.8 0.0 1.2 1 0 0 1 1 1 1 RasGEF domain Ribosomal_S7 PF00177.21 ELR22800.1 - 3.7e-38 130.5 0.8 4.6e-38 130.2 0.8 1.1 1 0 0 1 1 1 1 Ribosomal protein S7p/S5e Cnd1 PF12717.7 ELR22801.1 - 3.8e-46 157.1 7.4 1.3e-42 145.6 2.1 3.6 4 0 0 4 4 4 2 non-SMC mitotic condensation complex subunit 1 Cnd1_N PF12922.7 ELR22801.1 - 1.8e-18 66.9 0.0 1.8e-18 66.9 0.0 3.9 4 0 0 4 4 4 1 non-SMC mitotic condensation complex subunit 1, N-term HEAT PF02985.22 ELR22801.1 - 6.9e-05 22.8 3.8 0.74 10.2 0.0 5.3 6 0 0 6 6 6 2 HEAT repeat Adaptin_N PF01602.20 ELR22801.1 - 9.5e-05 21.1 8.9 0.00073 18.2 2.3 3.7 3 1 0 3 3 3 2 Adaptin N terminal region Cnd3 PF12719.7 ELR22801.1 - 0.0016 17.7 4.5 0.0046 16.2 3.4 2.4 2 0 0 2 2 2 1 Nuclear condensing complex subunits, C-term domain RTP1_C1 PF10363.9 ELR22801.1 - 0.2 11.8 5.3 12 6.1 1.0 3.4 2 1 0 2 2 2 0 Required for nuclear transport of RNA pol II C-terminus 1 DED PF01335.21 ELR22801.1 - 0.52 10.7 4.6 0.54 10.6 0.0 3.1 3 0 0 3 3 3 0 Death effector domain zf-RING_2 PF13639.6 ELR22802.1 - 0.011 16.0 8.9 0.037 14.4 9.0 1.8 1 1 0 1 1 1 0 Ring finger domain RasGEF PF00617.19 ELR22803.1 - 1.6e-91 305.3 3.6 4.1e-62 209.5 1.9 2.6 2 0 0 2 2 2 2 RasGEF domain RasGEF_N PF00618.20 ELR22803.1 - 1.7e-47 160.0 5.8 2e-26 92.2 0.3 3.4 3 0 0 3 3 3 2 RasGEF N-terminal motif Hemocyanin_N PF03722.14 ELR22803.1 - 0.0027 18.2 0.3 0.013 16.0 0.3 2.3 1 0 0 1 1 1 1 Hemocyanin, all-alpha domain FAM101 PF15068.6 ELR22803.1 - 0.61 10.0 3.2 3.5 7.6 0.4 2.5 2 0 0 2 2 2 0 FAM101 family DnaI_N PF07319.11 ELR22803.1 - 2 9.1 7.7 49 4.7 1.7 4.8 4 0 0 4 4 4 0 Primosomal protein DnaI N-terminus GCV_T PF01571.21 ELR22804.1 - 9.5e-82 274.2 0.0 1.2e-81 273.9 0.0 1.1 1 0 0 1 1 1 1 Aminomethyltransferase folate-binding domain GCV_T_C PF08669.11 ELR22804.1 - 1.9e-17 63.0 0.1 4.1e-17 61.9 0.1 1.6 1 0 0 1 1 1 1 Glycine cleavage T-protein C-terminal barrel domain Trehalose_PPase PF02358.16 ELR22804.1 - 0.025 13.7 0.0 0.039 13.1 0.0 1.2 1 0 0 1 1 1 0 Trehalose-phosphatase SoxG PF04268.12 ELR22804.1 - 0.029 14.5 0.0 1.5 9.0 0.0 2.3 2 0 0 2 2 2 0 Sarcosine oxidase, gamma subunit family Metallophos PF00149.28 ELR22805.1 - 2e-10 41.5 0.1 7.7e-10 39.6 0.1 1.9 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 ELR22805.1 - 3e-05 24.3 0.0 4.6e-05 23.7 0.0 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Ank_2 PF12796.7 ELR22806.1 - 7.4e-27 93.8 0.2 6.2e-09 36.3 0.0 8.6 6 2 2 8 8 8 6 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ELR22806.1 - 8e-21 74.1 2.1 0.00058 20.4 0.0 11.3 8 3 3 11 11 11 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 ELR22806.1 - 4.4e-19 66.6 6.1 0.13 12.9 0.1 11.1 12 1 0 12 12 12 4 Ankyrin repeat Ank_5 PF13857.6 ELR22806.1 - 5.4e-18 64.8 8.2 0.00021 21.5 0.0 9.3 8 1 1 10 10 10 4 Ankyrin repeats (many copies) Ank PF00023.30 ELR22806.1 - 1.3e-16 60.2 8.9 0.083 13.4 0.0 10.4 11 0 0 11 11 11 5 Ankyrin repeat Hamartin PF04388.12 ELR22806.1 - 1.3 7.6 4.9 2.4 6.7 4.9 1.4 1 0 0 1 1 1 0 Hamartin protein PARP PF00644.20 ELR22807.1 - 5.5e-40 137.0 0.1 3.1e-39 134.6 0.0 2.0 2 0 0 2 2 2 1 Poly(ADP-ribose) polymerase catalytic domain PARP_reg PF02877.14 ELR22807.1 - 2.8e-13 50.2 0.1 5.8e-13 49.1 0.1 1.5 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase, regulatory domain WGR PF05406.15 ELR22807.1 - 0.11 12.6 0.1 0.11 12.6 0.1 1.9 2 0 0 2 2 2 0 WGR domain Hid1 PF12722.7 ELR22807.1 - 1.5 6.8 7.3 2.6 6.1 7.3 1.3 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein RNA_polI_A34 PF08208.11 ELR22807.1 - 2.9 7.9 25.1 0.44 10.6 15.0 2.6 2 0 0 2 2 2 0 DNA-directed RNA polymerase I subunit RPA34.5 eIF-3c_N PF05470.12 ELR22807.1 - 3.8 5.7 19.2 8.1 4.6 0.2 2.1 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit 8 N-terminus POT1 PF02765.17 ELR22808.1 - 5.9e-09 35.9 0.0 3.1e-07 30.3 0.0 2.3 1 1 0 1 1 1 1 Telomeric single stranded DNA binding POT1/CDC13 POT1PC PF16686.5 ELR22808.1 - 2.6e-06 27.4 0.0 0.0012 18.7 0.0 2.4 2 0 0 2 2 2 2 ssDNA-binding domain of telomere protection protein Rep_fac-A_C PF08646.10 ELR22808.1 - 0.057 13.2 0.0 0.12 12.1 0.0 1.5 1 0 0 1 1 1 0 Replication factor-A C terminal domain BORCS8 PF10167.9 ELR22808.1 - 0.15 12.0 0.0 0.32 11.0 0.0 1.4 1 0 0 1 1 1 0 BLOC-1-related complex sub-unit 8 DUF3439 PF11921.8 ELR22808.1 - 0.91 9.5 9.8 1.9 8.4 9.8 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) SSP160 PF06933.11 ELR22808.1 - 0.94 7.6 13.1 1.4 7.0 13.1 1.2 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 Mucin PF01456.17 ELR22808.1 - 2.2 8.3 19.8 0.55 10.2 15.4 2.1 2 0 0 2 2 2 0 Mucin-like glycoprotein ubiquitin PF00240.23 ELR22809.1 - 7.9e-35 118.4 0.8 1.1e-34 118.0 0.8 1.2 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 ELR22809.1 - 5.4e-17 61.4 0.8 8.4e-17 60.8 0.8 1.3 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like zf-AN1 PF01428.16 ELR22809.1 - 2.4e-11 43.6 6.8 2.4e-11 43.6 6.8 1.6 1 1 0 1 1 1 1 AN1-like Zinc finger Ubiquitin_2 PF14560.6 ELR22809.1 - 8.9e-06 26.1 0.2 3.5e-05 24.2 0.2 1.8 1 1 0 1 1 1 1 Ubiquitin-like domain TBK1_ULD PF18396.1 ELR22809.1 - 0.0033 17.3 0.1 0.0053 16.7 0.1 1.3 1 0 0 1 1 1 1 TANK binding kinase 1 ubiquitin-like domain Rad60-SLD_2 PF13881.6 ELR22809.1 - 0.0043 17.1 0.1 0.012 15.7 0.1 1.7 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_5 PF18037.1 ELR22809.1 - 0.0048 17.2 0.5 0.0076 16.6 0.1 1.5 2 0 0 2 2 2 1 Ubiquitin-like domain DUF2407 PF10302.9 ELR22809.1 - 0.0056 17.2 0.0 0.0059 17.1 0.0 1.2 1 0 0 1 1 1 1 DUF2407 ubiquitin-like domain Ubiquitin_4 PF18036.1 ELR22809.1 - 0.015 15.4 1.2 2.4 8.2 0.2 2.3 2 0 0 2 2 2 0 Ubiquitin-like domain Beta_helix PF13229.6 ELR22810.1 - 3.2e-12 46.6 39.2 4.5e-08 33.1 13.5 3.7 1 1 2 3 3 3 2 Right handed beta helix region DUF2861 PF11060.8 ELR22810.1 - 0.0018 17.9 3.0 0.21 11.1 0.2 2.2 1 1 1 2 2 2 2 Protein of unknown function (DUF2861) DUF2689 PF10894.8 ELR22810.1 - 0.07 12.9 0.5 11 5.9 0.2 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2689) Nucleopor_Nup85 PF07575.13 ELR22811.1 - 3.4e-92 309.8 12.0 4.6e-92 309.4 12.0 1.0 1 0 0 1 1 1 1 Nup85 Nucleoporin DUF1741 PF08427.10 ELR22811.1 - 0.018 14.7 0.2 0.049 13.3 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF1741) EF-1_beta_acid PF10587.9 ELR22811.1 - 0.83 10.2 6.5 5 7.7 0.6 2.8 2 0 0 2 2 2 0 Eukaryotic elongation factor 1 beta central acidic region zf-C3HC4_2 PF13923.6 ELR22814.1 - 4.7e-09 35.9 7.7 7e-09 35.4 7.7 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 ELR22814.1 - 2.3e-08 33.8 8.4 3.5e-08 33.2 8.4 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 ELR22814.1 - 3.1e-08 33.8 8.9 4.7e-08 33.2 8.9 1.3 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.7 ELR22814.1 - 8.4e-07 29.2 4.6 1.8e-06 28.1 4.6 1.5 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_3 PF13920.6 ELR22814.1 - 4.2e-06 26.5 5.7 6.7e-06 25.9 5.7 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 ELR22814.1 - 1.3e-05 24.9 7.1 2.4e-05 24.1 7.1 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 ELR22814.1 - 1.7e-05 24.6 7.5 2.8e-05 24.0 7.5 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 ELR22814.1 - 0.00013 21.9 2.6 0.00013 21.9 2.6 1.9 1 1 1 2 2 2 1 RING-type zinc-finger zf-ANAPC11 PF12861.7 ELR22814.1 - 0.012 15.7 1.9 0.02 14.9 1.9 1.3 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_4 PF15227.6 ELR22814.1 - 0.028 14.6 9.2 0.055 13.6 9.2 1.5 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-RING_4 PF14570.6 ELR22814.1 - 0.04 13.7 6.8 0.097 12.5 6.8 1.7 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-RING_6 PF14835.6 ELR22814.1 - 0.048 13.5 4.8 0.09 12.7 4.8 1.3 1 0 0 1 1 1 0 zf-RING of BARD1-type protein Rib_recp_KP_reg PF05104.12 ELR22814.1 - 0.077 14.0 11.3 0.16 13.0 4.5 2.8 2 0 0 2 2 2 0 Ribosome receptor lysine/proline rich region Siva PF05458.12 ELR22814.1 - 0.15 11.8 4.0 0.28 10.8 4.0 1.4 1 0 0 1 1 1 0 Cd27 binding protein (Siva) zf-RING_11 PF17123.5 ELR22814.1 - 0.24 11.2 6.9 0.44 10.3 6.9 1.5 1 0 0 1 1 1 0 RING-like zinc finger zf-MIZ PF02891.20 ELR22814.1 - 0.78 9.5 7.7 1.7 8.4 7.7 1.6 1 1 0 1 1 1 0 MIZ/SP-RING zinc finger zf-UDP PF14569.6 ELR22814.1 - 8.6 6.6 9.8 0.68 10.1 2.3 2.6 2 0 0 2 2 2 0 Zinc-binding RING-finger tRNA_Me_trans PF03054.16 ELR22815.1 - 1.6e-105 352.8 0.0 3.5e-105 351.7 0.0 1.5 1 1 0 1 1 1 1 tRNA methyl transferase NAD_synthase PF02540.17 ELR22815.1 - 8.2e-07 28.4 0.1 7.5e-06 25.2 0.1 2.2 1 1 0 1 1 1 1 NAD synthase Asn_synthase PF00733.21 ELR22815.1 - 6.3e-05 22.8 0.0 8.7e-05 22.3 0.0 1.1 1 0 0 1 1 1 1 Asparagine synthase ThiI PF02568.14 ELR22815.1 - 0.00029 20.5 0.0 0.00055 19.6 0.0 1.4 1 0 0 1 1 1 1 Thiamine biosynthesis protein (ThiI) ATP_bind_3 PF01171.20 ELR22815.1 - 0.013 15.3 0.0 0.067 12.9 0.0 2.0 1 1 0 1 1 1 0 PP-loop family QueC PF06508.13 ELR22815.1 - 0.018 14.5 0.0 0.085 12.3 0.0 1.9 2 0 0 2 2 2 0 Queuosine biosynthesis protein QueC Luteo_coat PF00894.18 ELR22815.1 - 0.15 12.0 0.0 0.82 9.6 0.0 2.0 2 0 0 2 2 2 0 Luteovirus coat protein Glyco_hydro_125 PF06824.11 ELR22816.1 - 1e-130 436.4 0.0 1.2e-130 436.1 0.0 1.0 1 0 0 1 1 1 1 Metal-independent alpha-mannosidase (GH125) HIT PF01230.23 ELR22818.1 - 5.1e-23 81.6 0.0 8.2e-23 81.0 0.0 1.3 1 0 0 1 1 1 1 HIT domain DcpS_C PF11969.8 ELR22818.1 - 1.3e-07 32.1 0.0 1.7e-07 31.7 0.0 1.2 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding CwfJ_C_1 PF04677.15 ELR22818.1 - 0.16 11.8 0.0 0.23 11.3 0.0 1.2 1 0 0 1 1 1 0 Protein similar to CwfJ C-terminus 1 Spermine_synth PF01564.17 ELR22819.1 - 3.8e-26 91.7 0.0 4.7e-26 91.4 0.0 1.1 1 0 0 1 1 1 1 Spermine/spermidine synthase domain MFS_1 PF07690.16 ELR22820.1 - 7.3e-09 35.0 8.8 8.6e-09 34.8 8.8 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily MFS_1_like PF12832.7 ELR22820.1 - 0.0014 17.5 0.2 0.0018 17.2 0.2 1.2 1 0 0 1 1 1 1 MFS_1 like family Sugar_tr PF00083.24 ELR22820.1 - 0.0016 17.4 3.0 0.002 17.1 3.0 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter LacY_symp PF01306.19 ELR22820.1 - 0.016 14.0 3.3 0.022 13.5 3.3 1.2 1 0 0 1 1 1 0 LacY proton/sugar symporter MFS_3 PF05977.13 ELR22820.1 - 0.06 11.7 0.1 0.072 11.5 0.1 1.1 1 0 0 1 1 1 0 Transmembrane secretion effector ABC_ATPase PF09818.9 ELR22821.1 - 2.6e-27 95.7 0.0 3.8e-27 95.2 0.0 1.2 1 0 0 1 1 1 1 Predicted ATPase of the ABC class Aldo_ket_red PF00248.21 ELR22822.1 - 2.7e-09 36.6 0.1 2.9e-09 36.6 0.1 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Cation_ATPase_C PF00689.21 ELR22823.1 - 5.1e-05 23.1 4.6 0.0006 19.6 4.6 2.0 1 1 0 1 1 1 1 Cation transporting ATPase, C-terminus GPS2_interact PF15784.5 ELR22823.1 - 0.41 11.1 8.5 0.72 10.3 8.5 1.4 1 0 0 1 1 1 0 G-protein pathway suppressor 2-interacting domain CAF-1_p150 PF11600.8 ELR22823.1 - 0.85 9.3 20.9 1.2 8.8 20.9 1.2 1 0 0 1 1 1 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal RRM_1 PF00076.22 ELR22824.1 - 3.7e-05 23.5 0.0 0.00012 21.9 0.0 2.0 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF1825 PF08855.10 ELR22824.1 - 0.02 14.8 0.0 0.1 12.5 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF1825) DUF2087 PF09860.9 ELR22824.1 - 0.03 14.5 0.0 0.065 13.4 0.0 1.5 1 1 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2087) ArdA PF07275.11 ELR22824.1 - 0.039 14.5 0.0 0.069 13.7 0.0 1.4 1 0 0 1 1 1 0 Antirestriction protein (ArdA) Methyltransf_16 PF10294.9 ELR22826.1 - 2.7e-09 37.0 0.0 9.8e-09 35.2 0.0 1.9 2 1 0 2 2 2 1 Lysine methyltransferase Methyltransf_12 PF08242.12 ELR22826.1 - 2.5e-06 28.2 0.0 5.5e-06 27.0 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 ELR22826.1 - 0.00017 21.5 0.0 0.00054 19.8 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 ELR22826.1 - 0.0018 18.9 0.0 0.0036 18.0 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 ELR22826.1 - 0.0026 17.2 0.0 0.0034 16.8 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_11 PF08241.12 ELR22826.1 - 0.0063 17.1 0.0 0.013 16.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain DUF727 PF05303.12 ELR22826.1 - 0.058 13.5 0.0 5.2 7.2 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF727) TehB PF03848.14 ELR22826.1 - 0.091 12.2 0.0 0.15 11.4 0.0 1.3 1 0 0 1 1 1 0 Tellurite resistance protein TehB MTS PF05175.14 ELR22826.1 - 0.19 11.3 0.0 0.31 10.6 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain Ras PF00071.22 ELR22827.1 - 3.7e-49 166.4 0.0 1.1e-27 96.6 0.0 2.1 2 0 0 2 2 2 2 Ras family Roc PF08477.13 ELR22827.1 - 2.3e-15 56.9 0.0 3.2e-09 37.0 0.0 2.3 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR22827.1 - 1.1e-05 25.0 0.0 0.0092 15.5 0.0 2.1 2 0 0 2 2 2 2 ADP-ribosylation factor family RsgA_GTPase PF03193.16 ELR22827.1 - 0.00017 21.5 0.1 0.33 10.8 0.1 2.2 2 0 0 2 2 2 2 RsgA GTPase YTH PF04146.15 ELR22827.1 - 0.05 13.6 0.0 0.066 13.1 0.0 1.2 1 0 0 1 1 1 0 YT521-B-like domain GTP_EFTU PF00009.27 ELR22827.1 - 0.051 13.1 0.3 7 6.1 0.0 2.5 2 1 1 3 3 3 0 Elongation factor Tu GTP binding domain AAA_5 PF07728.14 ELR22827.1 - 0.093 12.7 0.2 12 5.9 0.0 2.5 2 1 0 2 2 2 0 AAA domain (dynein-related subfamily) MMR_HSR1_Xtn PF16897.5 ELR22827.1 - 0.17 11.9 0.0 0.28 11.2 0.0 1.3 1 0 0 1 1 1 0 C-terminal region of MMR_HSR1 domain Prefoldin PF02996.17 ELR22828.1 - 1.6e-24 86.1 2.6 2.2e-24 85.7 2.6 1.1 1 0 0 1 1 1 1 Prefoldin subunit Prefoldin_3 PF13758.6 ELR22828.1 - 0.00013 21.9 0.3 0.00028 20.9 0.1 1.7 1 1 0 1 1 1 1 Prefoldin subunit Spectrin PF00435.21 ELR22828.1 - 0.0041 17.6 1.9 2.3 8.8 0.1 2.2 2 0 0 2 2 2 2 Spectrin repeat Metal_resist PF13801.6 ELR22828.1 - 0.015 15.4 2.6 0.089 13.0 0.2 2.1 2 0 0 2 2 2 0 Heavy-metal resistance ATPase PF06745.13 ELR22828.1 - 0.058 12.7 0.2 0.075 12.4 0.2 1.2 1 0 0 1 1 1 0 KaiC NYD-SP28 PF14772.6 ELR22828.1 - 0.082 13.0 4.9 0.63 10.1 0.2 2.4 2 0 0 2 2 2 0 Sperm tail DUF4140 PF13600.6 ELR22828.1 - 0.085 13.3 0.6 1.2 9.6 0.1 2.0 2 0 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) KxDL PF10241.9 ELR22828.1 - 0.11 12.7 3.9 5.8 7.3 0.9 2.2 2 0 0 2 2 2 0 Uncharacterized conserved protein HIP1_clath_bdg PF16515.5 ELR22828.1 - 0.12 12.9 9.0 0.27 11.9 1.0 2.1 2 0 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 CLZ PF16526.5 ELR22828.1 - 0.24 11.8 7.7 1.7 9.1 0.9 2.5 2 0 0 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels AAA_6 PF12774.7 ELR22830.1 - 1.6e-139 464.5 0.0 8.7e-139 462.0 0.0 2.4 2 0 0 2 2 2 1 Hydrolytic ATP binding site of dynein motor region DHC_N1 PF08385.12 ELR22830.1 - 2.6e-113 379.6 5.9 2.6e-113 379.6 5.9 3.1 5 0 0 5 5 5 1 Dynein heavy chain, N-terminal region 1 DHC_N2 PF08393.13 ELR22830.1 - 7.2e-103 344.8 8.3 7.2e-103 344.8 8.3 4.8 3 1 0 3 3 3 1 Dynein heavy chain, N-terminal region 2 AAA_9 PF12781.7 ELR22830.1 - 2.5e-73 245.9 0.0 2.5e-73 245.9 0.0 4.1 5 0 0 5 5 4 1 ATP-binding dynein motor region AAA_8 PF12780.7 ELR22830.1 - 2.9e-67 226.7 0.0 3.4e-66 223.2 0.0 2.8 2 1 0 2 2 2 1 P-loop containing dynein motor region D4 Dynein_C PF18199.1 ELR22830.1 - 3.4e-49 167.7 0.0 8.7e-47 159.8 0.0 3.0 2 0 0 2 2 2 1 Dynein heavy chain C-terminal domain AAA_7 PF12775.7 ELR22830.1 - 1.4e-44 151.8 0.0 1.5e-37 128.8 0.0 4.4 4 0 0 4 4 4 2 P-loop containing dynein motor region MT PF12777.7 ELR22830.1 - 6.1e-37 127.4 15.0 1.3e-36 126.3 15.0 1.6 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor AAA_5 PF07728.14 ELR22830.1 - 2.6e-33 115.0 0.0 6e-13 49.0 0.0 6.2 4 1 0 4 4 4 4 AAA domain (dynein-related subfamily) Dynein_heavy PF03028.15 ELR22830.1 - 8.2e-22 77.5 0.0 5.8e-21 74.8 0.0 2.6 1 0 0 1 1 1 1 Dynein heavy chain region D6 P-loop domain AAA_lid_11 PF18198.1 ELR22830.1 - 2.6e-20 72.9 0.0 6e-20 71.7 0.0 1.6 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain Dynein_AAA_lid PF17852.1 ELR22830.1 - 4.1e-17 62.5 0.0 1.8e-16 60.4 0.0 2.2 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain AAA_22 PF13401.6 ELR22830.1 - 8.1e-14 52.1 0.3 0.018 15.3 0.0 6.9 6 0 0 6 6 5 3 AAA domain AAA PF00004.29 ELR22830.1 - 1.8e-13 51.0 0.0 0.013 15.9 0.0 4.8 4 0 0 4 4 4 3 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 ELR22830.1 - 1e-09 39.0 7.1 0.83 10.0 0.0 8.4 6 1 1 7 7 6 3 AAA ATPase domain AAA_33 PF13671.6 ELR22830.1 - 7.2e-09 36.0 0.1 0.15 12.2 0.0 5.2 5 0 0 5 5 4 2 AAA domain AAA_18 PF13238.6 ELR22830.1 - 1.9e-07 31.7 1.2 4.4 7.9 0.0 5.7 5 0 0 5 5 4 1 AAA domain AAA_lid_1 PF17857.1 ELR22830.1 - 3.7e-06 27.1 0.1 0.00011 22.3 0.0 3.1 2 0 0 2 2 2 1 AAA+ lid domain AAA_30 PF13604.6 ELR22830.1 - 2.4e-05 24.1 0.8 5 6.8 0.0 4.6 4 0 0 4 4 4 1 AAA domain T2SSE PF00437.20 ELR22830.1 - 6.2e-05 22.2 0.0 0.12 11.4 0.0 3.9 4 0 0 4 4 4 1 Type II/IV secretion system protein AAA_19 PF13245.6 ELR22830.1 - 0.0007 19.9 5.1 0.05 13.9 0.0 4.7 6 0 0 6 6 3 1 AAA domain IstB_IS21 PF01695.17 ELR22830.1 - 0.001 18.8 2.5 0.3 10.8 0.0 4.6 5 0 0 5 5 5 1 IstB-like ATP binding protein PspA_IM30 PF04012.12 ELR22830.1 - 0.0011 18.6 2.6 0.0011 18.6 2.6 4.7 5 0 0 5 5 3 1 PspA/IM30 family Mg_chelatase PF01078.21 ELR22830.1 - 0.0031 16.9 4.2 0.37 10.1 0.0 3.8 5 0 0 5 5 3 1 Magnesium chelatase, subunit ChlI AAA_25 PF13481.6 ELR22830.1 - 0.0035 16.9 0.8 0.37 10.3 0.0 4.3 4 0 0 4 4 4 1 AAA domain ADIP PF11559.8 ELR22830.1 - 0.0098 16.0 0.3 0.0098 16.0 0.3 3.7 3 0 0 3 3 2 1 Afadin- and alpha -actinin-Binding DASH_Dam1 PF08653.10 ELR22830.1 - 0.01 15.6 0.1 1.7 8.5 0.0 4.2 3 0 0 3 3 3 0 DASH complex subunit Dam1 RNA_helicase PF00910.22 ELR22830.1 - 0.018 15.4 0.0 1e+02 3.4 0.0 4.2 4 0 0 4 4 4 0 RNA helicase AAA_28 PF13521.6 ELR22830.1 - 0.021 15.0 2.5 57 3.9 0.0 5.9 6 0 0 6 6 6 0 AAA domain AAA_29 PF13555.6 ELR22830.1 - 0.074 12.8 0.1 42 4.0 0.0 3.5 3 0 0 3 3 3 0 P-loop containing region of AAA domain AAA_24 PF13479.6 ELR22830.1 - 0.13 12.0 0.0 68 3.1 0.0 4.1 4 0 0 4 4 3 0 AAA domain NACHT PF05729.12 ELR22830.1 - 0.16 11.8 0.7 13 5.6 0.0 3.9 4 0 0 4 4 4 0 NACHT domain TMF_DNA_bd PF12329.8 ELR22830.1 - 0.26 11.3 16.5 1.1 9.3 0.3 3.5 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding H-kinase_dim PF02895.14 ELR22830.1 - 1.2 9.5 5.0 26 5.3 0.1 4.8 4 0 0 4 4 3 0 Signal transducing histidine kinase, homodimeric domain ERM PF00769.19 ELR22830.1 - 2 8.2 35.7 0.66 9.7 1.5 3.5 3 0 0 3 3 3 0 Ezrin/radixin/moesin family UPF0242 PF06785.11 ELR22830.1 - 8.4 6.4 23.6 3 7.9 0.2 3.5 3 0 0 3 3 3 0 Uncharacterised protein family (UPF0242) N-terminus PS_Dcarbxylase PF02666.15 ELR22831.1 - 6.4e-60 202.1 0.0 9.3e-60 201.6 0.0 1.3 1 0 0 1 1 1 1 Phosphatidylserine decarboxylase EF-hand_7 PF13499.6 ELR22831.1 - 1.4e-09 38.2 0.5 7.8e-09 35.9 0.1 2.4 3 0 0 3 3 3 1 EF-hand domain pair EF-hand_5 PF13202.6 ELR22831.1 - 9e-08 31.3 2.4 0.00021 20.6 0.2 2.9 3 0 0 3 3 3 2 EF hand EF-hand_1 PF00036.32 ELR22831.1 - 4.8e-07 28.9 2.7 0.0013 18.2 0.1 3.2 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.6 ELR22831.1 - 7.7e-07 28.6 1.1 0.0058 16.5 0.1 2.8 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.6 ELR22831.1 - 3.6e-06 26.7 3.1 0.00013 21.7 0.4 2.8 1 1 1 2 2 2 2 EF-hand domain pair C2 PF00168.30 ELR22832.1 - 2.6e-25 88.7 0.0 3.5e-25 88.3 0.0 1.2 1 0 0 1 1 1 1 C2 domain DOCK-C2 PF14429.6 ELR22832.1 - 0.099 12.4 0.0 0.14 12.0 0.0 1.4 1 1 0 1 1 1 0 C2 domain in Dock180 and Zizimin proteins tRNA-synt_1c PF00749.21 ELR22833.1 - 5.1e-113 377.1 0.0 9.6e-113 376.2 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain tRNA-synt_1c_C PF03950.18 ELR22833.1 - 7.6e-50 169.2 0.0 2.7e-49 167.4 0.0 1.9 2 0 0 2 2 2 1 tRNA synthetases class I (E and Q), anti-codon binding domain tRNA_synt_1c_R1 PF04558.15 ELR22833.1 - 1e-30 106.9 0.0 1.8e-30 106.1 0.0 1.4 1 0 0 1 1 1 1 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 1 tRNA_synt_1c_R2 PF04557.15 ELR22833.1 - 0.1 13.5 2.0 0.24 12.3 2.0 1.6 1 0 0 1 1 1 0 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2 DUF4375 PF14300.6 ELR22833.1 - 0.31 11.3 1.8 0.37 11.1 0.2 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4375) Epimerase PF01370.21 ELR22834.1 - 5.3e-25 88.3 0.0 6.9e-25 87.9 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 ELR22834.1 - 1.9e-16 60.4 0.0 9.9e-16 58.0 0.0 2.0 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase RmlD_sub_bind PF04321.17 ELR22834.1 - 5e-12 45.5 0.0 7.2e-12 45.0 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain 3Beta_HSD PF01073.19 ELR22834.1 - 3.8e-08 32.7 0.0 5.7e-08 32.1 0.0 1.3 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Polysacc_synt_2 PF02719.15 ELR22834.1 - 5e-07 29.1 0.0 0.00041 19.6 0.0 2.9 2 1 0 2 2 2 2 Polysaccharide biosynthesis protein NAD_binding_4 PF07993.12 ELR22834.1 - 2.6e-05 23.5 0.0 0.00023 20.4 0.0 2.3 2 1 0 2 2 2 1 Male sterility protein NAD_binding_10 PF13460.6 ELR22834.1 - 0.0015 18.4 0.0 0.013 15.3 0.0 2.1 2 0 0 2 2 2 1 NAD(P)H-binding DapB_N PF01113.20 ELR22834.1 - 0.062 13.4 0.0 0.11 12.7 0.0 1.4 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus EAR PF07897.11 ELR22834.1 - 0.1 12.2 2.5 0.28 10.8 2.5 1.7 1 0 0 1 1 1 0 Ethylene-responsive binding factor-associated repression adh_short PF00106.25 ELR22834.1 - 0.11 12.0 0.2 0.37 10.2 0.2 1.9 1 1 0 1 1 1 0 short chain dehydrogenase Ldh_1_N PF00056.23 ELR22834.1 - 0.15 12.2 0.0 0.23 11.6 0.0 1.4 1 0 0 1 1 1 0 lactate/malate dehydrogenase, NAD binding domain Semialdhyde_dh PF01118.24 ELR22834.1 - 0.15 12.5 0.0 0.3 11.5 0.0 1.5 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain WD40 PF00400.32 ELR22835.1 - 1.7e-43 145.7 13.9 5.3e-07 30.2 0.1 7.3 7 0 0 7 7 7 7 WD domain, G-beta repeat PRP4 PF08799.11 ELR22835.1 - 7.5e-14 51.0 8.6 4.9e-13 48.4 6.7 2.6 2 0 0 2 2 2 1 pre-mRNA processing factor 4 (PRP4) like ANAPC4_WD40 PF12894.7 ELR22835.1 - 3.5e-10 40.1 0.0 0.19 12.0 0.0 5.4 2 1 3 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ELR22835.1 - 1.2e-05 24.4 0.1 0.68 8.8 0.0 4.2 2 1 1 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ELR22835.1 - 0.0086 14.8 3.3 2 7.0 0.1 3.9 3 2 1 5 5 5 1 Nucleoporin Nup120/160 Nbas_N PF15492.6 ELR22835.1 - 0.016 14.5 0.0 0.092 12.1 0.0 2.2 2 1 1 3 3 3 0 Neuroblastoma-amplified sequence, N terminal WD40_like PF17005.5 ELR22835.1 - 0.07 12.4 0.0 1.8 7.8 0.0 2.2 1 1 1 2 2 2 0 WD40-like domain RNA_pol_Rpb6 PF01192.22 ELR22835.1 - 0.16 11.9 0.1 0.31 11.0 0.1 1.4 1 0 0 1 1 1 0 RNA polymerase Rpb6 ACOX PF01756.19 ELR22836.1 - 6.2e-38 130.1 0.5 6.6e-36 123.5 0.5 2.6 1 1 0 1 1 1 1 Acyl-CoA oxidase Acyl-CoA_dh_M PF02770.19 ELR22836.1 - 3e-17 62.6 0.0 6.5e-17 61.5 0.0 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_ox_N PF14749.6 ELR22836.1 - 7.9e-15 55.5 0.1 1.4e-13 51.5 0.0 2.5 2 0 0 2 2 2 1 Acyl-coenzyme A oxidase N-terminal Acyl-CoA_dh_1 PF00441.24 ELR22836.1 - 1.1e-05 25.7 0.4 7e-05 23.1 0.4 2.4 1 1 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain SAGA-Tad1 PF12767.7 ELR22837.1 - 0.11 12.2 0.1 0.17 11.6 0.1 1.2 1 0 0 1 1 1 0 Transcriptional regulator of RNA polII, SAGA, subunit DP PF08781.10 ELR22838.1 - 8.1e-34 116.5 0.0 2.1e-33 115.2 0.0 1.6 1 0 0 1 1 1 1 Transcription factor DP E2F_TDP PF02319.20 ELR22838.1 - 5.5e-25 87.2 0.3 9.6e-25 86.4 0.3 1.4 1 0 0 1 1 1 1 E2F/DP family winged-helix DNA-binding domain DUF4805 PF16063.5 ELR22838.1 - 0.028 13.8 1.4 0.054 12.8 1.4 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4805) Tex_N PF09371.10 ELR22838.1 - 0.076 12.7 1.6 0.14 11.8 0.2 1.9 2 0 0 2 2 2 0 Tex-like protein N-terminal domain Gar1 PF04410.14 ELR22839.1 - 4.7e-31 107.7 0.0 4.7e-31 107.7 0.0 2.9 3 0 0 3 3 3 1 Gar1/Naf1 RNA binding region Gly_rich PF12810.7 ELR22839.1 - 0.36 10.7 6.8 1.2 9.0 1.1 2.5 3 0 0 3 3 3 0 Glycine rich protein CENP-B_dimeris PF09026.10 ELR22839.1 - 9.1 6.7 23.0 1.5 9.3 1.0 3.3 3 0 0 3 3 3 0 Centromere protein B dimerisation domain Vps26 PF03643.15 ELR22840.1 - 9.1e-11 41.3 0.0 7.2e-09 35.0 0.0 2.1 2 0 0 2 2 2 2 Vacuolar protein sorting-associated protein 26 Arrestin_N PF00339.29 ELR22840.1 - 0.025 14.6 0.4 0.19 11.8 0.0 2.4 3 0 0 3 3 3 0 Arrestin (or S-antigen), N-terminal domain FHA PF00498.26 ELR22842.1 - 1.6e-06 28.3 0.0 2.9e-06 27.5 0.0 1.4 1 0 0 1 1 1 1 FHA domain Forkhead PF00250.18 ELR22842.1 - 3e-06 27.4 0.0 6e-06 26.4 0.0 1.4 1 0 0 1 1 1 1 Forkhead domain RNA_pol_3_Rpc31 PF11705.8 ELR22842.1 - 0.0045 17.3 8.0 0.0045 17.3 8.0 2.5 3 0 0 3 3 3 1 DNA-directed RNA polymerase III subunit Rpc31 TFIIA PF03153.13 ELR22842.1 - 0.036 14.1 11.2 0.14 12.2 4.6 2.0 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Cwf_Cwc_15 PF04889.12 ELR22842.1 - 0.8 9.4 19.4 0.05 13.3 10.2 2.4 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein PPP4R2 PF09184.11 ELR22842.1 - 1.4 8.5 15.2 0.43 10.1 5.5 2.1 2 0 0 2 2 2 0 PPP4R2 Hid1 PF12722.7 ELR22842.1 - 2.3 6.2 3.5 4 5.5 3.5 1.3 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein DUF1084 PF06454.11 ELR22843.1 - 1.4e-13 50.9 12.3 2.2e-13 50.3 12.3 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1084) DUF4293 PF14126.6 ELR22843.1 - 7.7 6.7 10.7 19 5.5 0.1 3.4 2 1 0 2 2 2 0 Domain of unknown function (DUF4293) Eapp_C PF10238.9 ELR22844.1 - 1.6e-32 112.7 10.8 7.3e-23 81.3 1.5 2.7 2 1 1 3 3 3 2 E2F-associated phosphoprotein Yippee-Mis18 PF03226.14 ELR22844.1 - 0.00042 20.5 3.6 0.00071 19.8 3.6 1.3 1 0 0 1 1 1 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly NUDE_C PF04880.13 ELR22844.1 - 0.17 12.4 6.1 3.1 8.2 0.0 2.1 2 0 0 2 2 2 0 NUDE protein, C-terminal conserved region PH PF00169.29 ELR22845.1 - 1.6e-08 35.0 0.0 3.3e-08 34.0 0.0 1.5 1 0 0 1 1 1 1 PH domain PH_11 PF15413.6 ELR22845.1 - 0.00078 19.8 0.0 0.002 18.5 0.0 1.7 1 0 0 1 1 1 1 Pleckstrin homology domain PH_8 PF15409.6 ELR22845.1 - 0.0078 16.5 0.0 0.016 15.5 0.0 1.4 1 0 0 1 1 1 1 Pleckstrin homology domain Amino_oxidase PF01593.24 ELR22846.1 - 3.2e-48 165.1 0.1 3.6e-30 105.6 0.0 2.1 1 1 1 2 2 2 2 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 ELR22846.1 - 6.2e-13 48.8 0.7 1.6e-12 47.5 0.6 1.8 2 0 0 2 2 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 ELR22846.1 - 2.4e-08 34.0 0.8 9e-06 25.5 0.4 2.2 2 0 0 2 2 2 2 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 ELR22846.1 - 5.8e-08 32.2 2.6 8.4e-08 31.7 2.6 1.2 1 0 0 1 1 1 1 FAD binding domain FAD_oxidored PF12831.7 ELR22846.1 - 1.9e-06 27.5 1.6 2.5e-06 27.1 1.6 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 ELR22846.1 - 7.2e-06 25.4 0.1 1.1e-05 24.9 0.1 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 ELR22846.1 - 1.4e-05 24.0 0.1 2.4e-05 23.3 0.1 1.3 1 0 0 1 1 1 1 HI0933-like protein Pyr_redox PF00070.27 ELR22846.1 - 2.6e-05 24.7 0.5 0.00026 21.5 0.3 2.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 ELR22846.1 - 3.1e-05 23.3 0.9 6e-05 22.3 0.9 1.5 1 0 0 1 1 1 1 Glucose inhibited division protein A Pyr_redox_3 PF13738.6 ELR22846.1 - 0.00016 21.1 0.3 0.015 14.6 0.2 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 ELR22846.1 - 0.0004 19.7 0.3 0.0004 19.7 0.3 2.6 3 0 0 3 3 3 1 Thi4 family FAD_binding_3 PF01494.19 ELR22846.1 - 0.00067 19.0 0.4 0.001 18.4 0.4 1.2 1 0 0 1 1 1 1 FAD binding domain Lycopene_cycl PF05834.12 ELR22846.1 - 0.0079 15.3 1.4 0.0091 15.1 0.2 1.6 2 0 0 2 2 2 1 Lycopene cyclase protein AlaDh_PNT_C PF01262.21 ELR22846.1 - 0.04 13.2 0.4 0.077 12.3 0.4 1.4 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain 3HCDH_N PF02737.18 ELR22846.1 - 0.11 12.4 0.1 0.2 11.5 0.1 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain UDPG_MGDP_dh_N PF03721.14 ELR22846.1 - 0.2 11.2 0.0 0.42 10.2 0.0 1.5 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Nup54 PF13874.6 ELR22847.1 - 8e-29 100.5 0.2 8e-29 100.5 0.2 1.5 2 0 0 2 2 2 1 Nucleoporin complex subunit 54 Nup54_C PF18437.1 ELR22847.1 - 0.00034 20.5 1.7 0.00034 20.5 1.7 1.9 2 0 0 2 2 2 1 Nup54 C-terminal interacting domain Post_transc_reg PF13797.6 ELR22847.1 - 0.074 12.9 0.0 3.3 7.6 0.0 2.4 1 1 1 2 2 2 0 Post-transcriptional regulator Birna_RdRp PF04197.12 ELR22847.1 - 0.086 11.1 0.0 0.11 10.8 0.0 1.0 1 0 0 1 1 1 0 Birnavirus RNA dependent RNA polymerase (VP1) Actin PF00022.19 ELR22848.1 - 3.4e-92 309.2 0.0 2.5e-90 303.0 0.0 2.0 1 1 0 1 1 1 1 Actin FtsA PF14450.6 ELR22848.1 - 0.005 17.2 0.1 0.2 12.1 0.0 2.9 2 1 0 2 2 2 1 Cell division protein FtsA Amidinotransf PF02274.17 ELR22849.1 - 6.2e-45 153.8 0.0 6.7e-44 150.4 0.0 1.9 1 1 0 1 1 1 1 Amidinotransferase RlaP PF10127.9 ELR22849.1 - 8.8e-10 38.6 0.1 2.4e-09 37.2 0.0 1.7 2 0 0 2 2 2 1 RNA repair pathway DNA polymerase beta family Arm PF00514.23 ELR22850.1 - 1.8e-07 31.0 2.0 0.0065 16.5 0.0 2.8 3 0 0 3 3 3 2 Armadillo/beta-catenin-like repeat Atx10homo_assoc PF09759.9 ELR22850.1 - 0.00058 19.8 0.2 0.0016 18.4 0.1 1.8 2 0 0 2 2 2 1 Spinocerebellar ataxia type 10 protein domain Arm_2 PF04826.13 ELR22850.1 - 0.011 15.2 1.8 0.51 9.8 0.3 2.1 1 1 0 2 2 2 0 Armadillo-like KAP PF05804.12 ELR22850.1 - 0.16 10.0 0.5 6.6 4.7 0.1 1.7 1 1 1 2 2 2 0 Kinesin-associated protein (KAP) RskA PF10099.9 ELR22851.1 - 0.016 15.5 6.5 0.021 15.2 6.5 1.3 1 0 0 1 1 1 0 Anti-sigma-K factor rskA Arm_2 PF04826.13 ELR22851.1 - 0.11 11.9 0.1 0.14 11.5 0.1 1.1 1 0 0 1 1 1 0 Armadillo-like LCAT PF02450.15 ELR22852.1 - 1.4e-20 73.8 0.0 9.9e-19 67.8 0.0 2.0 2 0 0 2 2 2 2 Lecithin:cholesterol acyltransferase Abhydrolase_1 PF00561.20 ELR22852.1 - 0.00012 21.8 0.1 0.00031 20.5 0.0 1.7 2 0 0 2 2 2 1 alpha/beta hydrolase fold DUF900 PF05990.12 ELR22852.1 - 0.00087 18.9 0.0 0.0013 18.3 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF900) Hydrolase_4 PF12146.8 ELR22852.1 - 0.0066 15.7 0.0 0.02 14.2 0.0 1.7 2 0 0 2 2 2 1 Serine aminopeptidase, S33 DUF676 PF05057.14 ELR22852.1 - 0.036 13.6 0.0 0.061 12.8 0.0 1.2 1 0 0 1 1 1 0 Putative serine esterase (DUF676) Ku PF02735.16 ELR22853.1 - 1.4e-41 142.4 0.0 3.3e-41 141.2 0.0 1.6 1 0 0 1 1 1 1 Ku70/Ku80 beta-barrel domain Ku_N PF03731.15 ELR22853.1 - 6.5e-36 124.1 0.0 7.5e-35 120.7 0.0 2.2 1 1 1 2 2 2 1 Ku70/Ku80 N-terminal alpha/beta domain Ku_C PF03730.14 ELR22853.1 - 3.6e-18 66.0 0.7 1e-17 64.6 0.7 1.8 1 0 0 1 1 1 1 Ku70/Ku80 C-terminal arm HeH PF12949.7 ELR22853.1 - 4e-07 29.6 0.2 8.5e-07 28.6 0.2 1.6 1 0 0 1 1 1 1 HeH/LEM domain SAP PF02037.27 ELR22853.1 - 6e-06 25.9 0.3 2.1e-05 24.2 0.3 2.0 1 0 0 1 1 1 1 SAP domain FANC_SAP PF18081.1 ELR22853.1 - 0.054 13.7 1.1 0.18 12.0 1.1 1.8 1 0 0 1 1 1 0 Fanconi anemia-associated nuclease SAP domain tRNA-synt_2d PF01409.20 ELR22854.1 - 8.4e-90 300.5 0.0 1.2e-89 300.0 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class II core domain (F) PheRS_DBD3 PF18553.1 ELR22854.1 - 2.6e-16 59.6 0.3 2.6e-15 56.4 0.0 2.8 3 0 0 3 3 3 1 PheRS DNA binding domain 3 PheRS_DBD1 PF18552.1 ELR22854.1 - 7e-09 35.3 0.5 1.7e-08 34.1 0.5 1.6 1 0 0 1 1 1 1 PheRS DNA binding domain 1 tRNA_synthFbeta PF17759.1 ELR22854.1 - 1.3e-06 28.1 0.0 1.2e-05 24.9 0.0 2.1 1 1 0 1 1 1 1 Phenylalanyl tRNA synthetase beta chain CLM domain tRNA-synt_2 PF00152.20 ELR22854.1 - 0.00017 20.8 0.2 0.0019 17.3 0.0 2.5 3 0 0 3 3 3 1 tRNA synthetases class II (D, K and N) MarR PF01047.22 ELR22854.1 - 0.0066 16.4 0.0 0.017 15.1 0.0 1.6 1 0 0 1 1 1 1 MarR family tRNA-synt_2b PF00587.25 ELR22854.1 - 0.0072 16.3 0.0 0.014 15.3 0.0 1.5 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HTH_CodY PF08222.11 ELR22854.1 - 0.055 13.0 0.0 0.12 12.0 0.0 1.5 1 0 0 1 1 1 0 CodY helix-turn-helix domain RasGAP PF00616.19 ELR22855.1 - 9.8e-21 74.4 0.0 1.1e-12 48.1 0.0 2.5 1 1 1 2 2 2 2 GTPase-activator protein for Ras-like GTPase MTP18 PF10558.9 ELR22856.1 - 2.3e-14 53.7 0.2 3.9e-08 33.4 0.0 2.2 1 1 1 2 2 2 2 Mitochondrial 18 KDa protein (MTP18) COG6 PF06419.11 ELR22857.1 - 4.3e-151 504.3 0.0 3.5e-150 501.2 0.0 1.9 1 1 0 1 1 1 1 Conserved oligomeric complex COG6 Roughex PF06020.11 ELR22858.1 - 0.2 10.7 1.4 0.4 9.7 1.4 1.5 1 0 0 1 1 1 0 Drosophila roughex protein PAT1 PF09770.9 ELR22858.1 - 0.62 8.3 10.1 0.78 7.9 10.1 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 V_ATPase_I PF01496.19 ELR22858.1 - 1.9 6.3 3.1 2.8 5.7 3.1 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF547 PF04784.14 ELR22859.1 - 7.9e-40 135.7 0.0 1.5e-39 134.8 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function, DUF547 DEP PF00610.21 ELR22859.1 - 4.3e-19 68.3 0.0 1.6e-09 37.7 0.0 2.6 2 0 0 2 2 2 2 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) Glutaredoxin PF00462.24 ELR22859.1 - 4.3e-11 42.9 0.0 9.6e-11 41.7 0.0 1.6 1 0 0 1 1 1 1 Glutaredoxin RCC1 PF00415.18 ELR22860.1 - 3.9e-47 158.6 17.1 1.6e-11 44.7 0.0 8.3 7 2 0 7 7 7 6 Regulator of chromosome condensation (RCC1) repeat CLU PF13236.6 ELR22860.1 - 5e-47 160.6 0.0 8.3e-47 159.8 0.0 1.4 1 0 0 1 1 1 1 Clustered mitochondria RCC1_2 PF13540.6 ELR22860.1 - 1e-25 88.9 34.2 1e-05 25.2 0.3 7.5 7 0 0 7 7 7 6 Regulator of chromosome condensation (RCC1) repeat eIF3_p135 PF12807.7 ELR22860.1 - 1.3e-13 51.4 1.4 2.5e-13 50.4 1.4 1.4 1 0 0 1 1 1 1 Translation initiation factor eIF3 subunit 135 DUF1681 PF07933.14 ELR22860.1 - 1.3e-09 37.9 0.0 3.8e-09 36.4 0.0 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF1681) PRIMA1 PF16101.5 ELR22860.1 - 0.13 12.3 0.7 0.43 10.6 0.7 1.9 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 PADR1 PF08063.12 ELR22862.1 - 4e-08 32.9 1.0 7.3e-08 32.1 1.0 1.3 1 0 0 1 1 1 1 PADR1 (NUC008) domain BRCT PF00533.26 ELR22862.1 - 0.069 13.5 0.1 0.25 11.7 0.0 2.0 2 1 0 2 2 2 0 BRCA1 C Terminus (BRCT) domain Slx4 PF09494.10 ELR22862.1 - 0.079 12.9 0.1 0.17 11.8 0.1 1.6 1 0 0 1 1 1 0 Slx4 endonuclease TFIIF_alpha PF05793.12 ELR22864.1 - 1.2 7.6 5.2 1.5 7.3 5.2 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) LRS4 PF10422.9 ELR22865.1 - 0.089 12.3 1.3 0.16 11.5 1.3 1.4 1 0 0 1 1 1 0 Monopolin complex subunit LRS4 Guanylate_kin PF00625.21 ELR22866.1 - 6.4e-63 211.7 0.0 7.3e-63 211.5 0.0 1.0 1 0 0 1 1 1 1 Guanylate kinase AAA_33 PF13671.6 ELR22866.1 - 1.9e-06 28.1 0.2 0.00098 19.3 0.0 2.3 2 1 0 2 2 2 1 AAA domain AAA_18 PF13238.6 ELR22866.1 - 2.1e-06 28.3 0.0 3.8e-06 27.5 0.0 1.4 1 1 0 1 1 1 1 AAA domain RsgA_GTPase PF03193.16 ELR22866.1 - 6.3e-05 22.9 0.0 0.00013 21.9 0.0 1.6 1 0 0 1 1 1 1 RsgA GTPase MMR_HSR1 PF01926.23 ELR22866.1 - 0.00019 21.5 0.0 0.00028 20.9 0.0 1.6 1 1 0 1 1 1 1 50S ribosome-binding GTPase ABC_tran PF00005.27 ELR22866.1 - 0.00062 20.3 0.1 0.00095 19.7 0.1 1.7 1 1 0 1 1 1 1 ABC transporter AAA_16 PF13191.6 ELR22866.1 - 0.001 19.5 0.0 0.0048 17.3 0.0 1.8 2 0 0 2 2 2 1 AAA ATPase domain AAA_7 PF12775.7 ELR22866.1 - 0.0026 17.3 0.0 0.0039 16.7 0.0 1.3 1 0 0 1 1 1 1 P-loop containing dynein motor region Thymidylate_kin PF02223.17 ELR22866.1 - 0.0027 17.4 0.1 1.1 8.9 0.0 2.2 2 0 0 2 2 2 2 Thymidylate kinase RNA_helicase PF00910.22 ELR22866.1 - 0.0028 18.0 0.0 0.0055 17.1 0.0 1.5 1 0 0 1 1 1 1 RNA helicase AAA_29 PF13555.6 ELR22866.1 - 0.0036 17.0 0.1 0.018 14.8 0.0 2.0 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_22 PF13401.6 ELR22866.1 - 0.0058 16.9 0.0 0.011 16.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_28 PF13521.6 ELR22866.1 - 0.007 16.6 0.6 0.054 13.7 0.5 2.2 1 1 0 1 1 1 1 AAA domain dNK PF01712.19 ELR22866.1 - 0.013 15.4 0.2 3 7.6 0.0 2.5 1 1 0 2 2 2 0 Deoxynucleoside kinase AAA PF00004.29 ELR22866.1 - 0.018 15.5 0.0 0.032 14.7 0.0 1.6 2 0 0 2 2 1 0 ATPase family associated with various cellular activities (AAA) NACHT PF05729.12 ELR22866.1 - 0.019 14.9 0.0 0.043 13.7 0.0 1.6 2 0 0 2 2 1 0 NACHT domain CPT PF07931.12 ELR22866.1 - 0.051 13.4 0.0 0.092 12.6 0.0 1.4 1 1 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein AAA_17 PF13207.6 ELR22866.1 - 0.052 14.0 0.8 0.2 12.0 0.5 2.2 1 1 0 1 1 1 0 AAA domain NTPase_1 PF03266.15 ELR22866.1 - 0.072 13.0 0.1 0.11 12.4 0.1 1.5 1 1 0 1 1 1 0 NTPase cobW PF02492.19 ELR22866.1 - 0.08 12.5 0.1 0.28 10.7 0.0 1.8 2 1 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain MobB PF03205.14 ELR22866.1 - 0.084 12.8 0.0 0.16 11.9 0.0 1.4 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_24 PF13479.6 ELR22866.1 - 0.1 12.3 0.1 0.15 11.8 0.0 1.5 2 0 0 2 2 1 0 AAA domain Roc PF08477.13 ELR22866.1 - 0.1 12.8 0.0 0.18 12.1 0.0 1.5 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase Viral_helicase1 PF01443.18 ELR22866.1 - 0.12 12.1 0.0 0.16 11.7 0.0 1.3 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase Rad17 PF03215.15 ELR22866.1 - 0.14 12.0 0.0 0.22 11.4 0.0 1.3 1 0 0 1 1 1 0 Rad17 P-loop domain SRPRB PF09439.10 ELR22866.1 - 0.15 11.5 0.0 0.26 10.7 0.0 1.6 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit MeaB PF03308.16 ELR22866.1 - 0.16 11.0 0.1 0.25 10.3 0.1 1.5 1 1 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB ADK PF00406.22 ELR22866.1 - 0.23 11.6 1.1 58 3.8 0.0 3.0 2 1 1 3 3 3 0 Adenylate kinase Cytidylate_kin PF02224.18 ELR22866.1 - 0.27 10.9 2.6 0.48 10.1 0.1 2.2 1 1 1 2 2 2 0 Cytidylate kinase AAA_23 PF13476.6 ELR22866.1 - 0.63 10.5 1.7 0.92 10.0 0.1 1.8 1 1 0 2 2 2 0 AAA domain OST3_OST6 PF04756.13 ELR22868.1 - 2.5e-36 125.5 0.0 3.3e-36 125.1 0.0 1.0 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family Profilin PF00235.19 ELR22869.1 - 3.9e-46 156.5 0.1 4.3e-46 156.3 0.1 1.0 1 0 0 1 1 1 1 Profilin DnaJ PF00226.31 ELR22870.1 - 6.4e-07 29.4 0.0 1.2e-06 28.6 0.0 1.5 1 0 0 1 1 1 1 DnaJ domain RPT PF13446.6 ELR22870.1 - 0.028 14.4 0.0 0.62 10.0 0.0 2.4 2 0 0 2 2 2 0 A repeated domain in UCH-protein Pox_MCEL PF03291.16 ELR22871.1 - 1.6e-45 155.7 0.1 2.7e-45 154.9 0.1 1.3 1 0 0 1 1 1 1 mRNA capping enzyme Methyltransf_12 PF08242.12 ELR22871.1 - 0.014 16.1 0.0 0.039 14.7 0.0 1.8 1 0 0 1 1 1 0 Methyltransferase domain COG7 PF10191.9 ELR22872.1 - 8.5e-121 404.6 10.8 5.7e-118 395.2 9.8 2.5 1 1 1 2 2 2 2 Golgi complex component 7 (COG7) Sec10 PF07393.11 ELR22872.1 - 2.3e-05 23.0 5.9 0.045 12.2 4.0 3.0 2 1 0 2 2 2 2 Exocyst complex component Sec10 LOH1CR12 PF10158.9 ELR22872.1 - 0.079 13.0 2.4 0.12 12.4 0.3 2.4 3 1 0 3 3 3 0 Tumour suppressor protein SesA PF17107.5 ELR22872.1 - 0.097 12.9 2.8 0.28 11.4 1.3 2.5 2 1 1 3 3 3 0 N-terminal domain on NACHT_NTPase and P-loop NTPases ABC2_membrane_2 PF12679.7 ELR22872.1 - 0.18 11.0 1.5 0.3 10.3 1.5 1.3 1 0 0 1 1 1 0 ABC-2 family transporter protein YlbD_coat PF14071.6 ELR22872.1 - 0.32 11.3 1.6 0.99 9.7 0.5 2.3 2 1 0 2 2 2 0 Putative coat protein NPV_P10 PF05531.12 ELR22872.1 - 0.66 10.5 3.9 1.2 9.7 0.5 3.0 2 1 1 3 3 3 0 Nucleopolyhedrovirus P10 protein Snapin_Pallidin PF14712.6 ELR22872.1 - 1.6 9.2 4.7 2.8 8.4 0.6 3.2 2 1 0 3 3 3 0 Snapin/Pallidin DUF4600 PF15372.6 ELR22872.1 - 1.6 9.1 4.0 0.62 10.5 0.3 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4600) DASH_Dad2 PF08654.10 ELR22872.1 - 1.9 8.9 5.5 0.72 10.3 1.2 2.5 2 1 0 3 3 3 0 DASH complex subunit Dad2 Metallophos PF00149.28 ELR22873.1 - 8.1e-11 42.8 0.1 1.4e-10 42.0 0.0 1.4 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Patatin PF01734.22 ELR22874.1 - 8e-21 75.2 0.1 2.1e-20 73.8 0.0 1.7 2 0 0 2 2 2 1 Patatin-like phospholipase Pkinase_Tyr PF07714.17 ELR22877.1 - 5.8e-14 52.0 0.0 2.3e-08 33.7 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 ELR22877.1 - 2.1e-11 43.7 0.0 1.8e-07 30.8 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ELR22878.1 - 4.1e-07 29.5 0.0 2.8e-06 26.8 0.0 1.9 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ELR22878.1 - 5.5e-06 25.9 0.0 9.9e-06 25.1 0.0 1.4 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR22879.1 - 1.1e-13 51.1 0.1 5.3e-07 29.2 0.0 2.1 1 1 1 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 ELR22879.1 - 6.3e-06 25.7 0.0 0.001 18.5 0.0 2.1 1 1 1 2 2 2 2 Protein kinase domain Sel1 PF08238.12 ELR22880.1 - 1.2e-09 38.5 8.6 5.4e-05 23.7 1.2 3.1 3 0 0 3 3 3 2 Sel1 repeat Lyase_1 PF00206.20 ELR22880.1 - 0.12 11.8 0.0 0.17 11.3 0.0 1.1 1 0 0 1 1 1 0 Lyase Ank_3 PF13606.6 ELR22881.1 - 6.8e-12 44.5 0.9 0.07 13.7 0.0 5.7 6 0 0 6 6 6 3 Ankyrin repeat Ank_2 PF12796.7 ELR22881.1 - 1.8e-10 41.3 0.1 0.055 14.1 0.0 4.1 3 1 0 3 3 3 3 Ankyrin repeats (3 copies) F-box-like PF12937.7 ELR22881.1 - 3.3e-10 39.7 0.5 1e-09 38.1 0.5 1.8 1 0 0 1 1 1 1 F-box-like Ank_4 PF13637.6 ELR22881.1 - 4.6e-09 36.6 0.0 0.018 15.6 0.0 4.6 4 0 0 4 4 4 2 Ankyrin repeats (many copies) Ank PF00023.30 ELR22881.1 - 7.2e-08 32.5 1.0 0.14 12.7 0.0 5.4 6 0 0 6 6 6 2 Ankyrin repeat F-box PF00646.33 ELR22881.1 - 0.00012 21.8 0.3 0.00039 20.2 0.0 1.9 2 0 0 2 2 2 1 F-box domain Ank_5 PF13857.6 ELR22881.1 - 0.031 14.6 0.0 8.3 6.9 0.0 3.6 3 1 0 3 3 3 0 Ankyrin repeats (many copies) Tho1_MOS11_C PF18592.1 ELR22881.1 - 0.033 14.0 0.0 0.073 12.9 0.0 1.5 1 0 0 1 1 1 0 Tho1/MOS11 C-terminal domain EGF_3 PF12947.7 ELR22884.1 - 0.0052 16.9 4.4 0.0052 16.9 4.4 3.0 4 0 0 4 4 4 1 EGF domain cEGF PF12662.7 ELR22884.1 - 0.037 13.9 1.8 0.037 13.9 1.8 3.4 3 0 0 3 3 3 0 Complement Clr-like EGF-like hEGF PF12661.7 ELR22884.1 - 0.051 14.2 0.3 0.051 14.2 0.3 4.2 4 1 0 4 4 4 0 Human growth factor-like EGF PRIMA1 PF16101.5 ELR22889.1 - 0.22 11.6 3.0 0.27 11.3 3.0 1.2 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 DEC-1_N PF04625.13 ELR22889.1 - 0.69 8.9 6.9 0.77 8.7 6.9 1.0 1 0 0 1 1 1 0 DEC-1 protein, N-terminal region Kelch_3 PF13415.6 ELR22890.1 - 1.9e-19 69.5 4.3 1.7e-09 37.7 0.0 3.5 3 0 0 3 3 3 3 Galactose oxidase, central domain Kelch_5 PF13854.6 ELR22890.1 - 1.1e-18 66.8 2.3 8.6e-09 35.2 0.0 3.4 3 0 0 3 3 3 3 Kelch motif Kelch_4 PF13418.6 ELR22890.1 - 5.3e-18 64.8 0.7 7.1e-08 32.3 0.1 3.5 3 0 0 3 3 3 3 Galactose oxidase, central domain Kelch_6 PF13964.6 ELR22890.1 - 9e-16 57.5 0.8 4.9e-06 26.6 0.0 3.4 3 0 0 3 3 3 3 Kelch motif Kelch_1 PF01344.25 ELR22890.1 - 7.8e-14 51.0 0.8 3e-06 26.7 0.0 3.3 3 0 0 3 3 3 2 Kelch motif Kelch_2 PF07646.15 ELR22890.1 - 8.3e-11 41.4 0.4 0.004 17.1 0.0 3.4 3 0 0 3 3 3 2 Kelch motif DUF333 PF03891.15 ELR22890.1 - 0.00046 20.3 0.2 0.0013 18.9 0.0 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF333) DUF4748 PF15932.5 ELR22890.1 - 3.1 7.6 4.6 0.82 9.5 1.1 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4748) Acetyltransf_1 PF00583.25 ELR22891.1 - 4.5e-13 49.5 0.0 5.1e-13 49.3 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 ELR22891.1 - 5.3e-10 39.3 0.0 6.2e-10 39.1 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 ELR22891.1 - 3.9e-08 33.6 0.0 5e-08 33.3 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 ELR22891.1 - 4.6e-07 29.7 0.0 5.5e-07 29.5 0.0 1.2 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_3 PF13302.7 ELR22891.1 - 0.0004 21.1 0.1 0.00049 20.8 0.1 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 ELR22891.1 - 0.0035 17.4 0.0 0.0042 17.2 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 ELR22891.1 - 0.045 13.9 0.1 0.11 12.6 0.0 1.6 1 1 1 2 2 2 0 GCN5-related N-acetyl-transferase Acetyltransf_6 PF13480.7 ELR22891.1 - 0.12 12.5 0.0 0.21 11.8 0.0 1.4 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.6 ELR22891.1 - 0.16 11.6 0.0 0.24 11.1 0.0 1.4 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain CsbD PF05532.12 ELR22892.1 - 0.00096 19.0 2.4 0.0017 18.2 2.4 1.3 1 0 0 1 1 1 1 CsbD-like PIGA PF08288.12 ELR22892.1 - 3.5 8.3 8.7 16 6.2 1.6 2.5 2 0 0 2 2 2 0 PIGA (GPI anchor biosynthesis) 6PGD PF00393.19 ELR22893.1 - 1.1e-118 395.9 0.0 1.4e-118 395.5 0.0 1.1 1 0 0 1 1 1 1 6-phosphogluconate dehydrogenase, C-terminal domain NAD_binding_2 PF03446.15 ELR22893.1 - 1.7e-52 177.8 0.2 2.7e-52 177.1 0.2 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase Shikimate_DH PF01488.20 ELR22893.1 - 6.3e-05 23.1 0.4 0.00016 21.8 0.2 1.7 1 1 1 2 2 2 1 Shikimate / quinate 5-dehydrogenase F420_oxidored PF03807.17 ELR22893.1 - 7.3e-05 23.3 0.0 0.00017 22.1 0.0 1.7 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent NAD_binding_11 PF14833.6 ELR22893.1 - 0.0009 19.5 0.0 0.0022 18.3 0.0 1.6 1 0 0 1 1 1 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase 2-Hacid_dh_C PF02826.19 ELR22893.1 - 0.014 14.8 0.1 0.026 13.9 0.1 1.4 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 3HCDH_N PF02737.18 ELR22893.1 - 0.063 13.2 0.1 0.12 12.3 0.1 1.5 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Methyltransf_16 PF10294.9 ELR22896.1 - 1.5e-15 57.4 0.0 7e-07 29.1 0.0 2.1 1 1 1 2 2 2 2 Lysine methyltransferase MTS PF05175.14 ELR22896.1 - 0.04 13.5 0.2 0.33 10.5 0.1 2.0 2 0 0 2 2 2 0 Methyltransferase small domain Methyltransf_31 PF13847.6 ELR22896.1 - 0.084 12.7 1.3 38 4.1 0.0 3.0 2 1 1 3 3 3 0 Methyltransferase domain AA_permease_2 PF13520.6 ELR22897.1 - 3.4e-20 72.3 15.9 7.5e-18 64.6 15.9 2.1 1 1 0 1 1 1 1 Amino acid permease PLDc_N PF13396.6 ELR22897.1 - 0.077 12.9 2.2 3.2 7.8 0.1 2.8 2 0 0 2 2 2 0 Phospholipase_D-nuclease N-terminal Sec62 PF03839.16 ELR22897.1 - 0.87 9.1 4.2 1.4 8.3 4.2 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 SLX9 PF15341.6 ELR22898.1 - 2.1 8.8 8.0 1.7 9.1 4.6 2.2 2 0 0 2 2 2 0 Ribosome biogenesis protein SLX9 RRN3 PF05327.11 ELR22899.1 - 3.3e-47 161.3 7.9 1e-22 80.4 4.6 2.9 1 1 2 3 3 3 3 RNA polymerase I specific transcription initiation factor RRN3 NOG1_N PF17835.1 ELR22900.1 - 3.1e-38 131.2 0.9 1.6e-37 129.0 0.2 2.3 2 0 0 2 2 2 1 NOG1 N-terminal helical domain NOG1 PF06858.14 ELR22900.1 - 3.1e-26 90.9 0.5 7.1e-26 89.8 0.5 1.7 1 0 0 1 1 1 1 Nucleolar GTP-binding protein 1 (NOG1) MMR_HSR1 PF01926.23 ELR22900.1 - 1.9e-19 69.8 0.0 4e-19 68.8 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase NOGCT PF08155.11 ELR22900.1 - 1.1e-16 60.6 2.9 1.1e-16 60.6 2.9 2.5 3 0 0 3 3 2 1 NOGCT (NUC087) domain FeoB_N PF02421.18 ELR22900.1 - 2.8e-14 52.9 0.1 4.4e-14 52.3 0.1 1.3 1 0 0 1 1 1 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 ELR22900.1 - 0.00041 20.3 0.0 0.075 12.9 0.0 2.4 2 0 0 2 2 2 1 RsgA GTPase GTP_EFTU PF00009.27 ELR22900.1 - 0.00053 19.6 0.0 0.0066 16.0 0.0 2.3 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Roc PF08477.13 ELR22900.1 - 0.0013 19.0 0.0 0.0051 17.0 0.0 2.0 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 ELR22900.1 - 0.0017 17.8 0.0 0.0042 16.5 0.0 1.7 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit AIG1 PF04548.16 ELR22900.1 - 0.0037 16.6 0.0 0.0096 15.3 0.0 1.7 2 0 0 2 2 2 1 AIG1 family Ras PF00071.22 ELR22900.1 - 0.0045 16.6 0.0 0.0084 15.7 0.0 1.4 1 0 0 1 1 1 1 Ras family Dynamin_N PF00350.23 ELR22900.1 - 0.0057 16.7 4.5 1.1 9.3 0.0 3.1 3 1 1 4 4 4 2 Dynamin family AAA_18 PF13238.6 ELR22900.1 - 0.024 15.2 0.1 0.93 10.0 0.0 3.0 3 0 0 3 3 3 0 AAA domain AAA_16 PF13191.6 ELR22900.1 - 0.069 13.5 0.2 0.31 11.4 0.0 2.3 2 1 0 2 2 2 0 AAA ATPase domain BRAP2 PF07576.12 ELR22901.1 - 4e-26 91.1 0.0 7.2e-26 90.3 0.0 1.4 1 0 0 1 1 1 1 BRCA1-associated protein 2 zf-UBP PF02148.19 ELR22901.1 - 5.3e-17 61.9 9.7 1.2e-16 60.7 9.7 1.7 1 0 0 1 1 1 1 Zn-finger in ubiquitin-hydrolases and other protein zf-C3HC4_2 PF13923.6 ELR22901.1 - 1.6e-05 24.6 5.5 1.6e-05 24.6 5.5 2.0 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) UPF0242 PF06785.11 ELR22901.1 - 9e-05 22.7 24.7 9e-05 22.7 24.7 1.6 2 0 0 2 2 1 1 Uncharacterised protein family (UPF0242) N-terminus zf-RING_2 PF13639.6 ELR22901.1 - 0.00016 21.9 11.6 0.00016 21.9 11.6 2.0 1 1 1 2 2 2 1 Ring finger domain zf-C3HC4 PF00097.25 ELR22901.1 - 0.00028 20.7 5.3 0.00028 20.7 5.3 1.8 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 ELR22901.1 - 0.00037 20.7 4.7 0.0012 19.1 4.7 1.9 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_11 PF17123.5 ELR22901.1 - 0.0014 18.3 3.9 0.0014 18.3 3.9 2.3 3 0 0 3 3 2 1 RING-like zinc finger zf-RING_UBOX PF13445.6 ELR22901.1 - 0.0023 17.9 4.9 0.0023 17.9 4.9 2.6 2 1 1 3 3 2 1 RING-type zinc-finger Spc7 PF08317.11 ELR22901.1 - 0.011 14.7 24.3 0.018 14.0 24.3 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein Macoilin PF09726.9 ELR22901.1 - 0.015 13.9 18.3 0.021 13.4 18.3 1.1 1 0 0 1 1 1 0 Macoilin family T3SSipB PF16535.5 ELR22901.1 - 0.027 15.0 13.9 0.048 14.1 13.9 1.3 1 0 0 1 1 1 0 Type III cell invasion protein SipB HOOK PF05622.12 ELR22901.1 - 0.028 12.6 26.7 0.017 13.3 4.3 2.1 1 1 1 2 2 2 0 HOOK protein DUF3138 PF11336.8 ELR22901.1 - 0.059 12.0 1.8 0.092 11.3 1.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) MAD PF05557.13 ELR22901.1 - 0.076 11.4 22.8 0.11 10.9 22.8 1.1 1 0 0 1 1 1 0 Mitotic checkpoint protein DUF4188 PF13826.6 ELR22901.1 - 0.096 13.0 2.3 0.23 11.8 2.3 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4188) V_ATPase_I PF01496.19 ELR22901.1 - 0.11 10.4 14.5 0.19 9.6 14.5 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family AAA_13 PF13166.6 ELR22901.1 - 0.11 11.1 17.4 0.17 10.5 17.4 1.1 1 0 0 1 1 1 0 AAA domain FUSC PF04632.12 ELR22901.1 - 0.12 10.9 2.0 0.17 10.4 2.0 1.2 1 0 0 1 1 1 0 Fusaric acid resistance protein family GAS PF13851.6 ELR22901.1 - 0.14 11.5 24.9 0.25 10.7 24.9 1.4 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding PHD PF00628.29 ELR22901.1 - 0.18 11.7 8.2 0.36 10.7 8.2 1.5 1 0 0 1 1 1 0 PHD-finger TRAF_BIRC3_bd PF16673.5 ELR22901.1 - 0.47 10.3 11.5 1.7 8.5 0.8 2.8 2 1 0 2 2 2 0 TNF receptor-associated factor BIRC3 binding domain DUF4407 PF14362.6 ELR22901.1 - 0.47 9.7 12.9 0.92 8.8 12.9 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) zf-ANAPC11 PF12861.7 ELR22901.1 - 0.49 10.5 7.1 0.62 10.2 6.0 1.7 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger TMPIT PF07851.13 ELR22901.1 - 0.53 9.5 13.5 0.86 8.8 13.5 1.3 1 0 0 1 1 1 0 TMPIT-like protein DUF3573 PF12097.8 ELR22901.1 - 0.7 8.6 5.0 1 8.1 5.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3573) LMBR1 PF04791.16 ELR22901.1 - 0.75 8.6 4.3 1 8.2 4.3 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein Lys-AminoMut_A PF09043.11 ELR22901.1 - 0.82 8.1 5.0 1.2 7.5 5.0 1.1 1 0 0 1 1 1 0 D-Lysine 5,6-aminomutase TIM-barrel domain of alpha subunit TolA_bind_tri PF16331.5 ELR22901.1 - 1.2 9.2 16.6 0.35 11.0 10.1 2.9 1 1 2 3 3 3 0 TolA binding protein trimerisation Fib_alpha PF08702.10 ELR22901.1 - 1.7 8.8 16.3 0.2 11.8 10.3 2.1 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family ECH_2 PF16113.5 ELR22901.1 - 1.8 8.0 8.9 2.6 7.4 8.9 1.2 1 0 0 1 1 1 0 Enoyl-CoA hydratase/isomerase FAM76 PF16046.5 ELR22901.1 - 2.1 7.6 14.4 4.7 6.5 14.4 1.6 1 0 0 1 1 1 0 FAM76 protein FapA PF03961.13 ELR22901.1 - 2.9 6.4 13.5 4.9 5.6 13.5 1.4 1 0 0 1 1 1 0 Flagellar Assembly Protein A zf-RING_5 PF14634.6 ELR22901.1 - 4.1 7.5 12.9 11 6.1 10.2 2.3 1 1 1 2 2 2 0 zinc-RING finger domain FlaC_arch PF05377.11 ELR22901.1 - 4.2 7.9 11.2 24 5.4 1.4 3.6 1 1 3 4 4 4 0 Flagella accessory protein C (FlaC) ZapB PF06005.12 ELR22901.1 - 5.1 7.6 26.4 1.2 9.6 11.4 3.1 1 1 0 2 2 2 0 Cell division protein ZapB DUF1664 PF07889.12 ELR22901.1 - 5.6 7.0 11.7 4.4 7.4 8.2 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) CENP-K PF11802.8 ELR22901.1 - 6.8 6.2 26.5 3.5 7.1 18.8 2.2 1 1 1 2 2 2 0 Centromere-associated protein K BRI3BP PF14965.6 ELR22901.1 - 7.7 6.0 5.5 13 5.3 0.1 2.6 3 0 0 3 3 3 0 Negative regulator of p53/TP53 Exonuc_VII_L PF02601.15 ELR22901.1 - 8.7 5.8 16.4 7.5 6.0 14.5 1.8 2 0 0 2 2 2 0 Exonuclease VII, large subunit Prominin PF05478.11 ELR22901.1 - 9.3 4.1 9.5 14 3.5 9.5 1.2 1 0 0 1 1 1 0 Prominin RNA_ligase PF09414.10 ELR22902.1 - 4.4e-29 101.9 0.0 6e-29 101.4 0.0 1.1 1 0 0 1 1 1 1 RNA ligase Pyr_redox_2 PF07992.14 ELR22904.1 - 1.1e-51 175.9 0.1 1.2e-51 175.7 0.1 1.0 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 ELR22904.1 - 1.9e-18 66.8 0.1 5.1e-15 55.5 0.0 2.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 ELR22904.1 - 3.9e-18 65.8 0.1 3e-16 59.8 0.0 2.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 ELR22904.1 - 1.2e-05 24.6 2.8 0.042 12.9 0.3 3.5 4 1 0 4 4 4 2 Glucose inhibited division protein A FAD_oxidored PF12831.7 ELR22904.1 - 0.00026 20.5 1.1 0.0012 18.2 0.5 2.2 2 1 1 3 3 3 1 FAD dependent oxidoreductase Thi4 PF01946.17 ELR22904.1 - 0.00034 19.9 0.9 0.0018 17.6 0.1 2.3 2 1 1 3 3 3 1 Thi4 family NAD_binding_8 PF13450.6 ELR22904.1 - 0.0021 18.2 0.6 0.026 14.7 0.2 2.3 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 ELR22904.1 - 0.019 14.1 6.6 0.086 11.9 1.0 2.6 4 0 0 4 4 4 0 FAD binding domain NAD_binding_7 PF13241.6 ELR22904.1 - 0.023 15.1 0.2 0.22 12.0 0.0 2.4 2 1 0 2 2 2 0 Putative NAD(P)-binding HI0933_like PF03486.14 ELR22904.1 - 0.044 12.5 0.8 0.36 9.5 0.4 2.5 3 0 0 3 3 3 0 HI0933-like protein Hyphal_reg_CWP PF11765.8 ELR22904.1 - 0.18 10.7 0.1 3.4 6.5 0.0 2.0 1 1 1 2 2 2 0 Hyphally regulated cell wall protein N-terminal K_oxygenase PF13434.6 ELR22904.1 - 0.22 10.6 0.0 1.3 8.0 0.0 2.2 2 1 1 3 3 3 0 L-lysine 6-monooxygenase (NADPH-requiring) PhoLip_ATPase_C PF16212.5 ELR22905.1 - 3.4e-64 217.0 22.8 3.4e-64 217.0 22.8 2.3 2 0 0 2 2 2 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 ELR22905.1 - 3.5e-24 84.3 0.5 3.5e-24 84.3 0.5 3.4 3 0 0 3 3 3 1 Phospholipid-translocating ATPase N-terminal Cation_ATPase PF13246.6 ELR22905.1 - 5.1e-13 48.9 0.0 6.7e-12 45.3 0.0 2.4 2 0 0 2 2 2 1 Cation transport ATPase (P-type) E1-E2_ATPase PF00122.20 ELR22905.1 - 1.4e-07 31.3 0.6 8.3e-07 28.7 0.0 2.6 2 1 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.26 ELR22905.1 - 2.5e-06 27.9 8.0 0.0082 16.4 0.0 3.4 3 1 0 3 3 3 2 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 ELR22905.1 - 0.0049 16.6 0.0 0.011 15.5 0.0 1.5 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Alg6_Alg8 PF03155.15 ELR22906.1 - 6.3e-129 431.1 24.7 1.8e-100 337.2 8.7 2.1 1 1 1 2 2 2 2 ALG6, ALG8 glycosyltransferase family ALG3 PF05208.13 ELR22906.1 - 0.001 18.6 1.5 0.0021 17.6 1.5 1.5 1 0 0 1 1 1 1 ALG3 protein 7tm_1 PF00001.21 ELR22906.1 - 0.013 14.9 0.0 0.088 12.1 0.0 2.4 3 2 1 4 4 4 0 7 transmembrane receptor (rhodopsin family) PUMA PF15826.5 ELR22906.1 - 1.1 9.4 4.4 2.4 8.3 4.4 1.5 1 0 0 1 1 1 0 Bcl-2-binding component 3, p53 upregulated modulator of apoptosis F-box PF00646.33 ELR22907.1 - 0.0094 15.8 0.3 0.019 14.8 0.3 1.5 1 0 0 1 1 1 1 F-box domain DUF4326 PF14216.6 ELR22908.1 - 1.6e-20 73.6 0.1 2.7e-20 72.9 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4326) START PF01852.19 ELR22909.1 - 1.5e-49 168.2 0.0 7.8e-25 87.5 0.0 2.0 1 1 1 2 2 2 2 START domain zf_Hakai PF18408.1 ELR22909.1 - 2e-06 27.4 0.0 0.095 12.4 0.0 2.4 2 0 0 2 2 2 2 C2H2 Hakai zinc finger domain Calsequestrin PF01216.17 ELR22909.1 - 0.002 17.2 0.1 1.7 7.6 0.0 2.1 2 0 0 2 2 2 2 Calsequestrin Ub-RnfH PF03658.14 ELR22909.1 - 0.0087 16.4 0.3 8.6 6.8 0.0 2.6 3 0 0 3 3 2 2 RnfH family Ubiquitin FtsQ PF03799.15 ELR22909.1 - 0.013 16.3 0.0 17 6.3 0.0 3.1 2 2 1 3 3 3 0 Cell division protein FtsQ Pept_S41_N PF18294.1 ELR22909.1 - 0.017 15.1 0.0 9.2 6.3 0.0 2.5 2 0 0 2 2 2 0 Peptidase S41 N-terminal domain PhoU_div PF01865.16 ELR22909.1 - 0.031 13.6 0.6 7.5 5.8 0.1 2.5 2 0 0 2 2 2 0 Protein of unknown function DUF47 DUF684 PF05075.14 ELR22909.1 - 0.033 13.2 0.0 24 3.8 0.0 3.7 4 0 0 4 4 4 0 Protein of unknown function (DUF684) BtrH_N PF14399.6 ELR22909.1 - 0.043 14.1 0.0 52 4.1 0.0 3.4 2 2 0 4 4 4 0 Butirosin biosynthesis protein H, N-terminal Vert_HS_TF PF06546.11 ELR22909.1 - 0.13 11.9 0.0 0.75 9.4 0.0 1.9 2 0 0 2 2 2 0 Vertebrate heat shock transcription factor Baculo_PEP_C PF04513.12 ELR22909.1 - 0.26 11.3 1.5 21 5.1 0.1 2.7 3 0 0 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF1059 PF06348.11 ELR22909.1 - 1.9 8.8 3.7 38 4.6 0.3 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1059) Homeodomain PF00046.29 ELR22910.1 - 1.5e-13 50.3 0.1 2.8e-13 49.5 0.1 1.4 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 ELR22910.1 - 0.014 15.3 0.4 0.027 14.4 0.4 1.5 1 0 0 1 1 1 0 Homeobox KN domain IMD PF08397.11 ELR22912.1 - 1.4e-15 57.3 4.2 1.9e-15 56.8 4.2 1.1 1 0 0 1 1 1 1 IRSp53/MIM homology domain T2SSF PF00482.23 ELR22912.1 - 0.026 14.5 0.3 0.071 13.1 0.0 1.9 2 0 0 2 2 2 0 Type II secretion system (T2SS), protein F Amidinotransf PF02274.17 ELR22912.1 - 0.046 12.8 0.1 0.07 12.2 0.1 1.2 1 0 0 1 1 1 0 Amidinotransferase DUF4745 PF15923.5 ELR22912.1 - 0.051 13.6 0.2 0.1 12.6 0.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4745) DUF4407 PF14362.6 ELR22912.1 - 0.1 12.0 6.7 0.17 11.2 6.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) BAR_3 PF16746.5 ELR22912.1 - 0.12 12.1 3.8 0.17 11.6 3.8 1.2 1 0 0 1 1 1 0 BAR domain of APPL family Remorin_C PF03763.13 ELR22912.1 - 0.63 9.9 11.4 2.2 8.2 11.4 1.9 1 1 0 1 1 1 0 Remorin, C-terminal region RsbRD_N PF14361.6 ELR22912.1 - 1.1 9.9 5.6 2.4 8.9 2.5 2.5 1 1 1 2 2 2 0 RsbT co-antagonist protein rsbRD N-terminal domain PIF1 PF05970.14 ELR22913.1 - 1.5e-49 169.2 3.5 9.1e-30 104.0 0.1 3.1 2 1 0 2 2 2 2 PIF1-like helicase AAA_30 PF13604.6 ELR22913.1 - 7e-18 65.0 0.0 6e-15 55.5 0.0 2.3 2 0 0 2 2 2 2 AAA domain Herpes_Helicase PF02689.14 ELR22913.1 - 1.2e-05 23.5 0.0 0.00098 17.2 0.0 2.1 2 0 0 2 2 2 2 Helicase AAA_19 PF13245.6 ELR22913.1 - 1.2e-05 25.6 0.0 4.2e-05 23.9 0.0 1.9 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 ELR22913.1 - 0.00064 20.1 1.1 0.0022 18.4 0.0 2.4 2 0 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 ELR22913.1 - 0.0011 19.2 0.4 0.016 15.5 0.4 2.5 1 1 0 1 1 1 1 AAA domain Helicase_RecD PF05127.14 ELR22913.1 - 0.0041 17.0 0.0 0.011 15.7 0.0 1.7 1 0 0 1 1 1 1 Helicase TrwB_AAD_bind PF10412.9 ELR22913.1 - 0.017 14.1 0.1 0.026 13.5 0.1 1.2 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain UvrD_C_2 PF13538.6 ELR22913.1 - 0.018 14.9 0.0 0.051 13.4 0.0 1.8 1 0 0 1 1 1 0 UvrD-like helicase C-terminal domain ATPase_2 PF01637.18 ELR22913.1 - 0.03 14.3 0.0 0.065 13.1 0.0 1.5 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_11 PF13086.6 ELR22913.1 - 0.054 13.3 0.0 0.054 13.3 0.0 2.9 3 0 0 3 3 3 0 AAA domain AAA_7 PF12775.7 ELR22913.1 - 0.066 12.7 0.0 0.14 11.7 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region NTPase_1 PF03266.15 ELR22913.1 - 0.072 13.0 0.0 0.15 12.0 0.0 1.5 1 0 0 1 1 1 0 NTPase Mg_chelatase PF01078.21 ELR22913.1 - 0.073 12.5 0.0 0.14 11.5 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI RsgA_GTPase PF03193.16 ELR22913.1 - 0.16 11.9 0.0 0.3 11.0 0.0 1.4 1 0 0 1 1 1 0 RsgA GTPase DGF-1_C PF11040.8 ELR22913.1 - 6.5 6.8 7.8 36 4.5 7.8 2.3 1 0 0 1 1 1 0 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus TPR_2 PF07719.17 ELR22914.1 - 0.0039 17.2 0.2 0.37 11.0 0.0 3.7 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_1 PF00515.28 ELR22914.1 - 0.0071 16.1 0.2 0.6 10.0 0.0 3.1 3 0 0 3 3 3 1 Tetratricopeptide repeat Dehydrin PF00257.19 ELR22914.1 - 0.013 16.1 1.2 0.013 16.1 1.2 3.8 4 0 0 4 4 4 0 Dehydrin TPR_7 PF13176.6 ELR22914.1 - 0.028 14.4 0.0 2.2 8.5 0.0 3.4 2 0 0 2 2 2 0 Tetratricopeptide repeat RNA_pol_inhib PF16857.5 ELR22914.1 - 0.18 11.6 1.2 0.52 10.1 0.3 2.2 2 0 0 2 2 2 0 RNA polymerase inhibitor TPR_1 PF00515.28 ELR22915.1 - 1.5e-06 27.8 7.0 0.11 12.3 0.5 3.6 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_17 PF13431.6 ELR22915.1 - 0.0016 18.7 4.0 0.23 11.9 1.1 2.8 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_14 PF13428.6 ELR22915.1 - 0.0023 18.6 0.3 0.46 11.4 0.1 2.9 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_7 PF13176.6 ELR22915.1 - 0.016 15.2 6.4 0.68 10.1 0.0 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_19 PF14559.6 ELR22915.1 - 0.044 14.3 1.6 1.3 9.6 0.1 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_2 PF07719.17 ELR22915.1 - 0.064 13.4 8.8 0.96 9.7 0.3 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat ANAPC3 PF12895.7 ELR22915.1 - 0.12 12.6 7.6 0.26 11.6 7.6 1.4 1 0 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 3 DUF2644 PF10841.8 ELR22915.1 - 0.19 12.0 0.0 0.48 10.7 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2644) MORN PF02493.20 ELR22916.1 - 1.5e-14 52.9 19.7 8.7e-06 25.3 0.3 5.8 5 0 0 5 5 5 3 MORN repeat SET PF00856.28 ELR22916.1 - 6.8e-07 29.8 0.4 5.4e-05 23.6 0.1 3.0 2 1 0 2 2 2 1 SET domain DUF3048_C PF17479.2 ELR22916.1 - 0.0017 18.7 0.3 0.052 13.9 0.1 2.8 1 1 1 2 2 2 1 Protein of unknown function (DUF3048) C-terminal domain CDC45 PF02724.14 ELR22916.1 - 0.56 8.4 7.5 0.88 7.8 7.5 1.2 1 0 0 1 1 1 0 CDC45-like protein Nop14 PF04147.12 ELR22916.1 - 4 5.5 10.6 5.8 5.0 10.6 1.2 1 0 0 1 1 1 0 Nop14-like family Synaptobrevin PF00957.21 ELR22917.1 - 1.3e-17 63.3 4.4 1.4e-16 60.1 4.4 2.2 1 1 0 1 1 1 1 Synaptobrevin Longin PF13774.6 ELR22917.1 - 5.4e-14 52.0 0.0 9e-14 51.3 0.0 1.4 1 0 0 1 1 1 1 Regulated-SNARE-like domain PapA_C PF16911.5 ELR22917.1 - 0.042 13.9 0.0 0.15 12.2 0.0 1.8 2 0 0 2 2 2 0 Phthiocerol/phthiodiolone dimycocerosyl transferase C-terminus Exonuc_VII_L PF02601.15 ELR22917.1 - 0.11 12.1 1.8 0.14 11.7 1.8 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit AlaDh_PNT_N PF05222.15 ELR22918.1 - 1e-16 61.5 0.0 6.8e-08 32.9 0.0 2.5 2 0 0 2 2 2 2 Alanine dehydrogenase/PNT, N-terminal domain pP_pnuc_1 PF18165.1 ELR22918.1 - 0.066 13.1 0.0 0.15 12.0 0.0 1.5 1 0 0 1 1 1 0 Predicted pPIWI-associating nuclease ODV-E18 PF10717.9 ELR22918.1 - 2.8 7.9 10.7 0.11 12.3 1.9 2.2 2 0 0 2 2 2 0 Occlusion-derived virus envelope protein ODV-E18 PBP_like_2 PF12849.7 ELR22921.1 - 2.4e-12 47.1 2.4 3.2e-12 46.7 2.4 1.1 1 0 0 1 1 1 1 PBP superfamily domain EGF_2 PF07974.13 ELR22921.1 - 0.0036 17.7 13.2 0.0059 16.9 13.2 1.4 1 0 0 1 1 1 1 EGF-like domain EGF_Tenascin PF18720.1 ELR22921.1 - 1.6 8.9 5.7 3.9 7.6 5.7 1.7 1 0 0 1 1 1 0 Tenascin EGF domain DEAD PF00270.29 ELR22922.1 - 1.2e-23 83.8 6.9 1.6e-23 83.3 0.2 3.4 1 1 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ELR22922.1 - 1e-18 67.7 0.0 5.5e-18 65.3 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain Borrelia_P83 PF05262.11 ELR22922.1 - 0.00084 18.0 26.5 0.0011 17.6 26.5 1.3 1 0 0 1 1 1 1 Borrelia P83/100 protein DUF2749 PF10907.8 ELR22922.1 - 0.042 14.0 0.3 0.29 11.3 0.3 2.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2749) Red1 PF07964.11 ELR22922.1 - 0.43 8.8 48.7 0.59 8.3 48.7 1.1 1 0 0 1 1 1 0 Rec10 / Red1 XRN_M PF17846.1 ELR22922.1 - 3.3 6.6 19.8 5.4 5.9 19.8 1.4 1 0 0 1 1 1 0 Xrn1 helical domain XPG_I_2 PF12813.7 ELR22923.1 - 3.2e-10 39.9 0.0 6.6e-10 38.9 0.0 1.5 1 0 0 1 1 1 1 XPG domain containing Questin_oxidase PF14027.6 ELR22924.1 - 8.6e-43 147.2 0.0 1.3e-42 146.6 0.0 1.3 1 0 0 1 1 1 1 Questin oxidase-like DBD_HTH PF18430.1 ELR22924.1 - 0.089 12.6 0.1 0.26 11.1 0.1 1.8 1 0 0 1 1 1 0 Putative DNA-binding domain Ras PF00071.22 ELR22925.1 - 1.1e-53 181.1 0.1 1.3e-53 180.9 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR22925.1 - 5.1e-27 94.5 0.1 7.4e-27 93.9 0.1 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR22925.1 - 4.3e-10 39.3 0.0 5.6e-10 38.9 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 ELR22925.1 - 0.001 19.1 0.0 0.0015 18.6 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 ELR22925.1 - 0.0058 16.0 0.2 0.012 15.0 0.2 1.7 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 ELR22925.1 - 0.035 14.0 0.0 0.93 9.4 0.0 2.3 2 1 0 2 2 2 0 RsgA GTPase STALD PF18185.1 ELR22925.1 - 0.092 12.1 0.1 0.15 11.4 0.0 1.3 1 1 0 1 1 1 0 Sir2- and TIR-associating SLOG family AAA_22 PF13401.6 ELR22925.1 - 0.1 12.9 0.0 10 6.4 0.0 2.3 2 0 0 2 2 2 0 AAA domain Ribosomal_S7e PF01251.18 ELR22926.1 - 7.7e-82 273.5 2.4 8.7e-82 273.3 2.4 1.0 1 0 0 1 1 1 1 Ribosomal protein S7e ResIII PF04851.15 ELR22926.1 - 0.079 13.0 0.1 0.33 10.9 0.1 1.9 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit DOMON PF03351.17 ELR22927.1 - 8.5e-12 45.4 0.0 1.3e-11 44.8 0.0 1.3 1 0 0 1 1 1 1 DOMON domain UPF0020 PF01170.18 ELR22928.1 - 3.5e-28 98.6 0.1 2e-27 96.2 0.1 2.0 1 1 0 1 1 1 1 Putative RNA methylase family UPF0020 Methyltransf_31 PF13847.6 ELR22928.1 - 1.3e-12 47.8 0.0 2e-12 47.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ELR22928.1 - 7.8e-11 42.6 0.0 1.8e-10 41.4 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ELR22928.1 - 9.4e-10 39.0 0.1 2.7e-09 37.6 0.1 1.8 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 ELR22928.1 - 3.1e-07 30.1 0.0 5.4e-07 29.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain N6_Mtase PF02384.16 ELR22928.1 - 0.0008 18.8 0.0 0.0016 17.8 0.0 1.4 1 0 0 1 1 1 1 N-6 DNA Methylase Methyltransf_4 PF02390.17 ELR22928.1 - 0.001 18.5 0.1 0.0095 15.4 0.0 2.5 3 0 0 3 3 3 1 Putative methyltransferase Methyltransf_12 PF08242.12 ELR22928.1 - 0.0099 16.6 3.2 0.015 16.0 0.0 2.5 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_15 PF09445.10 ELR22928.1 - 0.035 13.7 0.0 0.057 13.0 0.0 1.3 1 0 0 1 1 1 0 RNA cap guanine-N2 methyltransferase Rtf2 PF04641.12 ELR22928.1 - 0.21 10.9 14.0 0.38 10.1 14.0 1.3 1 0 0 1 1 1 0 Rtf2 RING-finger DUF4228 PF14009.6 ELR22928.1 - 0.8 10.1 5.4 32 4.8 4.1 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4228) DUF2201_N PF13203.6 ELR22928.1 - 1.5 8.4 9.0 5.4 6.5 6.7 2.2 2 0 0 2 2 2 0 Putative metallopeptidase domain NOA36 PF06524.12 ELR22928.1 - 1.8 7.8 21.7 2.8 7.2 21.7 1.2 1 0 0 1 1 1 0 NOA36 protein Vfa1 PF08432.10 ELR22928.1 - 2.5 8.4 23.8 4.8 7.5 23.8 1.4 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Spem1 PF15670.5 ELR22928.1 - 2.6 7.5 9.9 4.4 6.8 9.9 1.2 1 0 0 1 1 1 0 Spermatid maturation protein 1 PPP4R2 PF09184.11 ELR22928.1 - 5 6.6 24.5 7.8 6.0 24.5 1.3 1 0 0 1 1 1 0 PPP4R2 SAPS PF04499.15 ELR22928.1 - 5.6 5.6 12.3 7.4 5.2 12.3 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein DUF913 PF06025.12 ELR22928.1 - 6 5.7 7.1 9.6 5.1 7.1 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) CDC45 PF02724.14 ELR22928.1 - 6.3 5.0 22.5 12 4.1 22.5 1.3 1 0 0 1 1 1 0 CDC45-like protein 2-Hacid_dh_C PF02826.19 ELR22929.1 - 1.8e-40 138.2 0.0 7.2e-25 87.4 0.0 3.9 3 1 0 3 3 3 3 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_binding_2 PF03446.15 ELR22929.1 - 0.0036 17.5 0.0 0.0074 16.5 0.0 1.5 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase Pkinase_Tyr PF07714.17 ELR22930.1 - 1.2e-70 237.8 0.0 2.1e-70 237.0 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ELR22930.1 - 5.8e-48 163.6 0.0 1.5e-47 162.2 0.0 1.7 1 0 0 1 1 1 1 Protein kinase domain Kinase-like PF14531.6 ELR22930.1 - 1.3e-05 24.7 0.1 0.00017 21.0 0.0 2.2 2 0 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 ELR22930.1 - 4.1e-05 22.5 3.0 5.1e-05 22.2 0.0 2.2 2 0 0 2 2 2 1 Fungal protein kinase FTA2 PF13095.6 ELR22930.1 - 0.00023 20.8 0.0 0.14 11.7 0.0 2.6 2 0 0 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 Kdo PF06293.14 ELR22930.1 - 0.0093 15.3 0.0 0.017 14.5 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 ELR22930.1 - 0.017 14.1 0.0 0.041 12.8 0.0 1.6 1 0 0 1 1 1 0 Haspin like kinase domain APH PF01636.23 ELR22930.1 - 0.036 14.0 0.0 0.1 12.5 0.0 1.8 2 0 0 2 2 2 0 Phosphotransferase enzyme family stn_TNFRSF12A PF12191.8 ELR22930.1 - 0.059 13.6 0.6 0.14 12.3 0.0 1.9 2 0 0 2 2 2 0 Tumour necrosis factor receptor stn_TNFRSF12A_TNFR domain RIO1 PF01163.22 ELR22930.1 - 0.11 12.1 0.1 0.11 12.1 0.1 1.7 2 0 0 2 2 2 0 RIO1 family SR-25 PF10500.9 ELR22931.1 - 8.7 5.9 7.6 26 4.3 7.6 1.7 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein WD40 PF00400.32 ELR22932.1 - 3.4e-28 97.3 18.5 1.3e-05 25.8 0.1 7.0 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ELR22932.1 - 4.4e-11 42.9 2.6 0.0083 16.4 0.1 5.6 1 1 5 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ELR22932.1 - 1.4e-08 34.5 0.0 4e-08 32.9 0.0 1.6 1 1 0 2 2 2 1 WD40-like domain BBS2_Mid PF14783.6 ELR22932.1 - 4e-06 26.8 0.6 0.16 12.1 0.0 3.3 3 1 1 4 4 4 2 Ciliary BBSome complex subunit 2, middle region Nup160 PF11715.8 ELR22932.1 - 3.8e-05 22.5 4.1 0.065 11.9 0.1 3.7 4 1 0 4 4 4 3 Nucleoporin Nup120/160 DUF1513 PF07433.11 ELR22932.1 - 0.00027 20.1 0.2 0.0074 15.4 0.1 2.2 1 1 0 2 2 2 1 Protein of unknown function (DUF1513) Frtz PF11768.8 ELR22932.1 - 0.01 14.2 0.0 0.016 13.5 0.0 1.4 1 0 0 1 1 1 0 WD repeat-containing and planar cell polarity effector protein Fritz DUF5046 PF16465.5 ELR22932.1 - 0.019 14.4 0.1 16 4.8 0.0 3.3 1 1 2 3 3 3 0 Domain of unknown function (DUF5046) PQQ_3 PF13570.6 ELR22932.1 - 0.032 14.7 5.7 12 6.6 0.0 5.2 5 1 0 5 5 5 0 PQQ-like domain Nucleoporin_N PF08801.11 ELR22932.1 - 0.12 11.0 0.1 0.38 9.4 0.0 1.9 3 0 0 3 3 3 0 Nup133 N terminal like CCDC53 PF10152.9 ELR22933.1 - 7e-06 26.5 0.0 8.3e-06 26.3 0.0 1.1 1 0 0 1 1 1 1 Subunit CCDC53 of WASH complex Phasin PF05597.11 ELR22933.1 - 0.013 15.5 0.1 0.014 15.4 0.1 1.1 1 0 0 1 1 1 0 Poly(hydroxyalcanoate) granule associated protein (phasin) EzrA PF06160.12 ELR22933.1 - 0.014 13.6 0.3 0.016 13.4 0.3 1.0 1 0 0 1 1 1 0 Septation ring formation regulator, EzrA TPR_8 PF13181.6 ELR22933.1 - 0.081 13.2 0.2 0.12 12.6 0.2 1.3 1 0 0 1 1 1 0 Tetratricopeptide repeat Allexi_40kDa PF05549.11 ELR22933.1 - 0.14 11.6 0.0 0.17 11.4 0.0 1.0 1 0 0 1 1 1 0 Allexivirus 40kDa protein zf-RING_2 PF13639.6 ELR22934.1 - 5.7e-08 33.0 6.4 5.7e-08 33.0 6.4 4.8 2 1 1 3 3 3 1 Ring finger domain zf-RING_5 PF14634.6 ELR22934.1 - 2.7e-07 30.4 5.6 2.7e-07 30.4 5.6 5.4 4 1 1 5 5 5 1 zinc-RING finger domain zf-CHY PF05495.12 ELR22934.1 - 4e-07 30.4 15.6 4e-07 30.4 15.6 4.2 2 2 1 3 3 3 1 CHY zinc finger zf-C3HC4_2 PF13923.6 ELR22934.1 - 3.7e-06 26.7 5.7 3.7e-06 26.7 5.7 4.7 4 1 1 5 5 5 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_1 PF14446.6 ELR22934.1 - 0.0012 18.7 0.6 0.0012 18.7 0.6 4.4 3 3 2 5 5 5 1 Prokaryotic RING finger family 1 zf-RING_4 PF14570.6 ELR22934.1 - 0.023 14.5 5.1 0.023 14.5 5.1 4.1 2 1 2 4 4 4 0 RING/Ubox like zinc-binding domain Pkinase_Tyr PF07714.17 ELR22935.1 - 2.8e-127 423.4 0.0 6.5e-63 212.4 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 ELR22935.1 - 7.7e-111 369.7 0.0 1.2e-56 192.0 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain PBP_like_2 PF12849.7 ELR22935.1 - 8.4e-17 61.7 12.6 1.1e-10 41.7 1.3 3.0 3 1 1 4 4 4 2 PBP superfamily domain Guanylate_cyc PF00211.20 ELR22935.1 - 1.6e-12 47.4 0.0 3.6e-12 46.3 0.0 1.5 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain APH PF01636.23 ELR22935.1 - 1.5e-07 31.6 0.0 0.00017 21.6 0.0 3.0 3 0 0 3 3 3 2 Phosphotransferase enzyme family Haspin_kinase PF12330.8 ELR22935.1 - 4.9e-05 22.4 0.1 0.026 13.5 0.0 3.0 3 0 0 3 3 3 1 Haspin like kinase domain Kinase-like PF14531.6 ELR22935.1 - 0.00019 20.8 0.0 0.1 11.9 0.0 2.7 3 0 0 3 3 3 2 Kinase-like Kdo PF06293.14 ELR22935.1 - 0.001 18.5 0.2 0.58 9.5 0.1 2.3 2 0 0 2 2 2 2 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 ELR22935.1 - 0.0035 17.0 1.6 0.47 10.0 0.2 2.7 2 1 1 3 3 3 1 RIO1 family SKG6 PF08693.10 ELR22935.1 - 0.0038 16.6 0.5 0.013 14.9 0.5 1.9 1 0 0 1 1 1 1 Transmembrane alpha-helix domain EGF_2 PF07974.13 ELR22935.1 - 0.009 16.4 9.4 0.017 15.5 9.4 1.5 1 0 0 1 1 1 1 EGF-like domain DUF347 PF03988.12 ELR22935.1 - 0.01 16.0 1.6 0.027 14.7 1.6 1.7 1 0 0 1 1 1 0 Repeat of Unknown Function (DUF347) FTA2 PF13095.6 ELR22935.1 - 0.097 12.3 0.0 1.1 8.8 0.0 2.5 3 1 1 4 4 4 0 Kinetochore Sim4 complex subunit FTA2 NurA PF09376.10 ELR22935.1 - 0.18 11.5 0.0 0.31 10.7 0.0 1.3 1 0 0 1 1 1 0 NurA domain PIP49_N PF14875.6 ELR22935.1 - 0.18 11.6 0.0 5.6 6.8 0.0 2.4 2 0 0 2 2 2 0 N-term cysteine-rich ER, FAM69 FAM199X PF15814.5 ELR22935.1 - 5.2 6.0 7.0 9.5 5.2 7.0 1.3 1 0 0 1 1 1 0 Protein family FAM199X FAD_binding_2 PF00890.24 ELR22936.1 - 4e-83 279.8 1.3 5.8e-83 279.3 1.3 1.2 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 ELR22936.1 - 3.7e-11 42.8 8.1 7.8e-07 28.6 1.9 2.8 2 1 1 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 ELR22936.1 - 4.8e-10 39.5 0.1 8e-10 38.8 0.1 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 ELR22936.1 - 1.9e-08 34.4 0.7 1.3e-07 31.7 0.1 2.7 3 0 0 3 3 3 1 NAD(P)-binding Rossmann-like domain FAD_oxidored PF12831.7 ELR22936.1 - 4.9e-08 32.7 1.6 1e-07 31.7 1.5 1.6 1 1 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 ELR22936.1 - 4.3e-07 29.5 0.1 1.4e-05 24.6 0.1 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 ELR22936.1 - 2.4e-06 26.5 3.6 0.00012 20.9 0.2 3.3 3 0 0 3 3 3 1 HI0933-like protein GIDA PF01134.22 ELR22936.1 - 3.5e-06 26.4 4.3 3.1e-05 23.2 0.8 3.0 3 0 0 3 3 3 1 Glucose inhibited division protein A Thi4 PF01946.17 ELR22936.1 - 1e-05 24.9 0.7 0.038 13.2 0.1 2.5 2 0 0 2 2 2 2 Thi4 family AlaDh_PNT_C PF01262.21 ELR22936.1 - 0.00014 21.2 2.8 0.00032 20.1 2.8 1.6 1 1 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain Pyr_redox PF00070.27 ELR22936.1 - 0.0011 19.5 0.5 0.021 15.4 0.2 2.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 ELR22936.1 - 0.0018 17.6 0.3 0.0031 16.8 0.3 1.3 1 0 0 1 1 1 1 FAD binding domain NAD_binding_7 PF13241.6 ELR22936.1 - 0.031 14.7 0.1 0.099 13.1 0.1 1.8 1 0 0 1 1 1 0 Putative NAD(P)-binding SpoIIIAH PF12685.7 ELR22936.1 - 0.16 11.8 0.8 0.31 10.8 0.8 1.5 1 0 0 1 1 1 0 SpoIIIAH-like protein DUF5521 PF17659.1 ELR22937.1 - 2.5e-17 62.0 0.0 8.4e-09 33.9 0.0 3.7 3 1 0 3 3 3 3 Family of unknown function (DUF5521) DUF5088 PF17008.5 ELR22937.1 - 0.0012 18.6 0.0 0.0064 16.2 0.0 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF5088) CDC24_OB3 PF17244.2 ELR22937.1 - 0.0036 17.1 0.0 0.066 12.9 0.0 2.2 2 0 0 2 2 2 1 Cell division control protein 24, OB domain 3 tRNA_anti-codon PF01336.25 ELR22937.1 - 0.0079 16.2 0.0 0.083 12.9 0.0 2.7 3 0 0 3 3 3 1 OB-fold nucleic acid binding domain FAM117 PF15388.6 ELR22937.1 - 0.38 10.1 3.0 0.84 9.0 3.0 1.5 1 0 0 1 1 1 0 Protein Family FAM117 Actin PF00022.19 ELR22938.1 - 1.3e-154 514.7 0.0 4.2e-154 513.1 0.0 1.6 1 1 0 1 1 1 1 Actin LCAT PF02450.15 ELR22939.1 - 4.3e-54 184.2 0.0 1.8e-43 149.2 0.0 2.1 1 1 1 2 2 2 2 Lecithin:cholesterol acyltransferase Lipase_2 PF01674.18 ELR22939.1 - 0.0018 17.8 0.0 0.0028 17.2 0.0 1.2 1 0 0 1 1 1 1 Lipase (class 2) DUF900 PF05990.12 ELR22939.1 - 0.0043 16.6 0.0 0.0066 16.0 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF900) Abhydrolase_6 PF12697.7 ELR22939.1 - 0.024 15.2 0.3 0.041 14.5 0.3 1.6 1 1 0 1 1 1 0 Alpha/beta hydrolase family DUF676 PF05057.14 ELR22939.1 - 0.043 13.3 0.0 0.067 12.7 0.0 1.2 1 0 0 1 1 1 0 Putative serine esterase (DUF676) C2 PF00168.30 ELR22940.1 - 4.6e-14 52.6 0.0 1.1e-10 41.7 0.0 2.4 2 0 0 2 2 2 2 C2 domain PX PF00787.24 ELR22940.1 - 2.2e-10 40.5 0.0 3.9e-10 39.7 0.0 1.4 1 0 0 1 1 1 1 PX domain WD40 PF00400.32 ELR22941.1 - 1.1e-07 32.4 0.6 4.5e-06 27.3 0.3 2.9 3 0 0 3 3 3 1 WD domain, G-beta repeat PQQ_3 PF13570.6 ELR22941.1 - 8.3e-05 23.0 0.1 0.18 12.3 0.0 3.1 3 0 0 3 3 3 1 PQQ-like domain ANAPC4_WD40 PF12894.7 ELR22941.1 - 0.074 13.4 0.0 0.81 10.0 0.0 2.4 1 1 1 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain BPS PF08947.10 ELR22941.1 - 0.14 12.0 0.1 0.3 11.0 0.1 1.5 1 0 0 1 1 1 0 BPS (Between PH and SH2) WD40 PF00400.32 ELR22942.1 - 3.5e-09 37.1 2.1 0.0022 18.8 0.3 2.4 2 0 0 2 2 2 2 WD domain, G-beta repeat Nup160 PF11715.8 ELR22942.1 - 0.011 14.5 0.1 0.014 14.1 0.1 1.2 1 0 0 1 1 1 0 Nucleoporin Nup120/160 PQQ PF01011.21 ELR22942.1 - 0.053 13.5 0.1 0.19 11.7 0.0 2.0 2 0 0 2 2 2 0 PQQ enzyme repeat Actin PF00022.19 ELR22943.1 - 6.6e-132 440.0 0.0 3.4e-131 437.6 0.0 1.8 1 1 0 1 1 1 1 Actin MreB_Mbl PF06723.13 ELR22943.1 - 0.004 16.0 0.0 0.25 10.1 0.0 2.7 1 1 0 1 1 1 1 MreB/Mbl protein SHMT PF00464.19 ELR22944.1 - 1.1e-199 663.1 0.0 1.2e-199 662.9 0.0 1.0 1 0 0 1 1 1 1 Serine hydroxymethyltransferase TctB PF07331.11 ELR22945.1 - 0.41 10.9 11.6 3.6 7.9 8.5 2.9 2 1 0 2 2 2 0 Tripartite tricarboxylate transporter TctB family CLU PF13236.6 ELR22946.1 - 3.5e-51 174.2 0.0 9.1e-51 172.8 0.0 1.8 1 1 0 1 1 1 1 Clustered mitochondria eIF3_p135 PF12807.7 ELR22946.1 - 2.8e-06 27.5 0.0 2.8e-06 27.5 0.0 3.3 3 0 0 3 3 3 1 Translation initiation factor eIF3 subunit 135 Drf_GBD PF06371.13 ELR22946.1 - 1.3e-05 24.9 0.8 5.4e-05 22.8 0.0 2.5 2 0 0 2 2 2 1 Diaphanous GTPase-binding Domain RICTOR_N PF14664.6 ELR22946.1 - 0.0025 16.9 1.1 0.0025 16.9 1.1 1.8 2 0 0 2 2 2 1 Rapamycin-insensitive companion of mTOR, N-term POTRA_TamA_1 PF17243.2 ELR22946.1 - 0.1 12.7 2.2 0.73 10.0 2.2 2.6 1 0 0 1 1 1 0 POTRA domain TamA domain 1 TPR_17 PF13431.6 ELR22946.1 - 0.18 12.3 0.1 2.3 8.8 0.1 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_11 PF13414.6 ELR22946.1 - 0.35 10.6 1.0 8.4 6.2 0.4 2.5 2 0 0 2 2 2 0 TPR repeat DUF3544 PF12064.8 ELR22947.1 - 0.076 13.3 4.4 0.093 13.0 4.4 1.0 1 0 0 1 1 1 0 Protein kinase C-binding protein 1 Profilin PF00235.19 ELR22949.1 - 3.1e-45 153.5 0.5 3.4e-45 153.4 0.5 1.0 1 0 0 1 1 1 1 Profilin CH PF00307.31 ELR22950.1 - 1.3e-36 125.1 0.3 2.3e-20 72.8 0.0 2.6 2 0 0 2 2 2 2 Calponin homology (CH) domain C2 PF00168.30 ELR22950.1 - 6.3e-27 93.9 0.1 1.2e-26 92.9 0.1 1.5 1 0 0 1 1 1 1 C2 domain CAMSAP_CH PF11971.8 ELR22950.1 - 6.9e-07 29.0 0.0 5.9e-05 22.8 0.0 2.5 2 0 0 2 2 2 2 CAMSAP CH domain Ras PF00071.22 ELR22951.1 - 3.5e-14 52.7 0.0 4.4e-14 52.4 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR22951.1 - 0.0035 17.6 0.0 0.0059 16.8 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR22951.1 - 0.0051 16.3 0.0 0.0063 16.0 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family RasGAP PF00616.19 ELR22952.1 - 0.012 15.4 0.0 0.02 14.6 0.0 1.3 1 0 0 1 1 1 0 GTPase-activator protein for Ras-like GTPase Peptidase_S8 PF00082.22 ELR22954.1 - 7.6e-50 169.9 0.3 3.7e-28 98.6 0.0 2.2 1 1 1 2 2 2 2 Subtilase family PA PF02225.22 ELR22954.1 - 3.6e-05 23.7 0.0 0.0002 21.3 0.0 2.3 2 0 0 2 2 2 1 PA domain ASH PF15780.5 ELR22954.1 - 0.12 12.6 0.1 0.31 11.2 0.1 1.7 1 0 0 1 1 1 0 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin Cupin_5 PF06172.11 ELR22955.1 - 3.6e-39 134.1 0.0 4.6e-39 133.8 0.0 1.1 1 0 0 1 1 1 1 Cupin superfamily (DUF985) CLU PF13236.6 ELR22956.1 - 9.8e-50 169.4 0.0 7.4e-48 163.3 0.0 2.9 3 0 0 3 3 3 1 Clustered mitochondria C2 PF00168.30 ELR22956.1 - 1.5e-24 86.2 0.0 3.8e-24 85.0 0.0 1.7 1 0 0 1 1 1 1 C2 domain eIF3_p135 PF12807.7 ELR22956.1 - 3.8e-06 27.1 1.5 9.1e-06 25.8 1.5 1.6 1 0 0 1 1 1 1 Translation initiation factor eIF3 subunit 135 Phage_int_SAM_2 PF12834.7 ELR22956.1 - 0.025 15.3 0.5 0.13 12.9 0.2 2.3 2 0 0 2 2 2 0 Phage integrase, N-terminal TPR_14 PF13428.6 ELR22956.1 - 0.25 12.2 2.9 2 9.4 1.2 3.0 1 1 1 2 2 2 0 Tetratricopeptide repeat Drf_GBD PF06371.13 ELR22957.1 - 0.0045 16.6 0.1 0.008 15.8 0.1 1.3 1 0 0 1 1 1 1 Diaphanous GTPase-binding Domain Drf_FH3 PF06367.16 ELR22957.1 - 0.051 13.2 0.0 0.086 12.5 0.0 1.3 1 0 0 1 1 1 0 Diaphanous FH3 Domain HEAT PF02985.22 ELR22957.1 - 0.086 13.1 0.1 0.29 11.5 0.1 2.0 1 0 0 1 1 1 0 HEAT repeat Pkinase_Tyr PF07714.17 ELR22958.1 - 4e-124 413.0 0.0 8.2e-62 208.8 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 ELR22958.1 - 9.3e-107 356.3 0.0 3.3e-56 190.6 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain PBP_like_2 PF12849.7 ELR22958.1 - 9.6e-37 127.2 9.5 5.8e-19 68.8 1.4 2.3 2 0 0 2 2 2 2 PBP superfamily domain Guanylate_cyc PF00211.20 ELR22958.1 - 2.1e-15 56.8 0.0 3.7e-15 56.0 0.0 1.3 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain APH PF01636.23 ELR22958.1 - 2e-06 27.9 3.2 0.00073 19.5 0.1 3.3 2 2 2 4 4 4 2 Phosphotransferase enzyme family Haspin_kinase PF12330.8 ELR22958.1 - 0.00033 19.7 0.0 0.044 12.7 0.0 2.7 3 0 0 3 3 3 1 Haspin like kinase domain Kdo PF06293.14 ELR22958.1 - 0.0011 18.4 0.3 0.48 9.8 0.1 2.4 2 0 0 2 2 2 2 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 ELR22958.1 - 0.0014 18.0 0.0 0.73 9.1 0.0 2.3 2 0 0 2 2 2 2 Kinase-like EGF_2 PF07974.13 ELR22958.1 - 0.0025 18.1 13.9 0.0048 17.2 13.9 1.5 1 0 0 1 1 1 1 EGF-like domain RIO1 PF01163.22 ELR22958.1 - 0.03 13.9 2.0 4.9 6.7 0.4 2.9 2 1 0 2 2 2 0 RIO1 family FTA2 PF13095.6 ELR22958.1 - 0.1 12.2 0.0 0.57 9.8 0.0 2.2 2 1 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 I-EGF_1 PF18372.1 ELR22958.1 - 0.52 10.4 5.4 1.1 9.4 5.4 1.5 1 0 0 1 1 1 0 Integrin beta epidermal growth factor like domain 1 EB PF01683.18 ELR22958.1 - 1.2 9.5 6.9 0.49 10.7 4.3 1.7 2 0 0 2 2 1 0 EB module EGF PF00008.27 ELR22958.1 - 3.9 7.9 8.0 8.7 6.8 8.0 1.6 1 0 0 1 1 1 0 EGF-like domain Laminin_EGF PF00053.24 ELR22958.1 - 4.3 7.5 9.3 9 6.5 9.3 1.5 1 0 0 1 1 1 0 Laminin EGF domain EGF_Tenascin PF18720.1 ELR22958.1 - 7.3 6.8 9.8 17 5.6 9.8 1.6 1 0 0 1 1 1 0 Tenascin EGF domain hEGF PF12661.7 ELR22958.1 - 8.2 7.2 8.4 23 5.8 8.4 1.8 1 0 0 1 1 1 0 Human growth factor-like EGF WD40 PF00400.32 ELR22959.1 - 3.1e-26 91.1 5.2 2e-05 25.2 0.0 6.3 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ELR22959.1 - 7.5e-07 29.4 0.7 1.8 8.9 0.0 5.4 3 2 0 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ELR22959.1 - 0.0006 18.9 0.0 0.055 12.4 0.0 3.0 2 1 1 3 3 3 1 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 ELR22959.1 - 0.021 14.7 0.1 28 4.8 0.0 4.1 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat DsbC_N PF10411.9 ELR22959.1 - 0.19 11.2 0.2 73 2.9 0.1 3.3 3 0 0 3 3 3 0 Disulfide bond isomerase protein N-terminus Utp14 PF04615.13 ELR22959.1 - 6.7 5.1 56.1 1.9 7.0 23.9 2.1 2 0 0 2 2 2 0 Utp14 protein CRT-like PF08627.10 ELR22960.1 - 8.5e-77 258.3 18.3 1e-76 258.0 18.3 1.1 1 0 0 1 1 1 1 CRT-like, chloroquine-resistance transporter-like SLC35F PF06027.12 ELR22960.1 - 4e-10 39.7 17.4 2.1e-06 27.5 2.4 2.1 2 0 0 2 2 2 2 Solute carrier family 35 EamA PF00892.20 ELR22960.1 - 5.4e-05 23.4 23.8 0.00034 20.8 9.9 2.9 2 1 1 3 3 3 2 EamA-like transporter family CENP_C_N PF15622.6 ELR22961.1 - 0.064 12.7 0.0 0.075 12.5 0.0 1.0 1 0 0 1 1 1 0 Kinetochore assembly subunit CENP-C N-terminal Pkinase PF00069.25 ELR22963.1 - 3.2e-18 66.1 0.0 2e-17 63.4 0.0 1.9 1 1 1 2 2 2 1 Protein kinase domain Pkinase_fungal PF17667.1 ELR22963.1 - 3.5e-10 39.3 0.0 1.5e-06 27.3 0.0 2.1 2 0 0 2 2 2 2 Fungal protein kinase Pkinase_Tyr PF07714.17 ELR22963.1 - 6.1e-09 35.5 0.0 2e-06 27.3 0.0 2.1 1 1 1 2 2 2 2 Protein tyrosine kinase PHD PF00628.29 ELR22963.1 - 9.3e-09 35.1 7.2 9.3e-09 35.1 7.2 2.2 2 0 0 2 2 2 1 PHD-finger APH PF01636.23 ELR22963.1 - 0.0025 17.8 1.9 0.057 13.3 0.2 2.4 1 1 1 2 2 2 1 Phosphotransferase enzyme family PHD_4 PF16866.5 ELR22963.1 - 1.2 9.3 5.4 3.6 7.8 5.4 1.8 1 0 0 1 1 1 0 PHD-finger RVT_2 PF07727.14 ELR22964.1 - 0.054 13.1 0.0 0.071 12.7 0.0 1.2 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) Retrotran_gag_2 PF14223.6 ELR22966.1 - 3.8e-05 23.4 0.0 4.5e-05 23.1 0.0 1.1 1 0 0 1 1 1 1 gag-polypeptide of LTR copia-type Pkinase_Tyr PF07714.17 ELR22967.1 - 5.9e-125 415.8 0.0 1.7e-61 207.8 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 ELR22967.1 - 8.7e-108 359.7 0.0 3.5e-54 183.9 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain PBP_like_2 PF12849.7 ELR22967.1 - 2e-20 73.6 3.6 2e-20 73.6 3.6 2.2 2 0 0 2 2 2 1 PBP superfamily domain Guanylate_cyc PF00211.20 ELR22967.1 - 1.3e-14 54.3 0.0 2.3e-14 53.4 0.0 1.3 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain APH PF01636.23 ELR22967.1 - 1.6e-07 31.5 1.4 0.00017 21.6 0.1 3.3 3 1 0 3 3 3 2 Phosphotransferase enzyme family Haspin_kinase PF12330.8 ELR22967.1 - 0.00049 19.2 0.0 0.037 13.0 0.0 2.3 2 0 0 2 2 2 1 Haspin like kinase domain Kinase-like PF14531.6 ELR22967.1 - 0.0012 18.3 0.0 0.84 8.9 0.0 2.4 2 0 0 2 2 2 2 Kinase-like RIO1 PF01163.22 ELR22967.1 - 0.0067 16.0 0.3 1.2 8.7 0.0 2.4 2 0 0 2 2 2 1 RIO1 family Kdo PF06293.14 ELR22967.1 - 0.015 14.6 0.2 4.9 6.5 0.0 2.4 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family EGF_2 PF07974.13 ELR22967.1 - 0.019 15.3 11.7 0.037 14.4 11.7 1.5 1 0 0 1 1 1 0 EGF-like domain FTA2 PF13095.6 ELR22967.1 - 0.089 12.4 0.0 2 8.0 0.0 2.6 3 1 0 3 3 3 0 Kinetochore Sim4 complex subunit FTA2 EGF PF00008.27 ELR22967.1 - 0.29 11.5 5.0 0.58 10.5 5.0 1.6 1 0 0 1 1 1 0 EGF-like domain PIP49_N PF14875.6 ELR22967.1 - 0.33 10.8 1.1 14 5.5 1.2 2.7 2 1 0 2 2 2 0 N-term cysteine-rich ER, FAM69 CLU PF13236.6 ELR22968.1 - 3.5e-53 180.7 0.0 1.1e-52 179.0 0.0 1.8 1 1 0 1 1 1 1 Clustered mitochondria C2 PF00168.30 ELR22968.1 - 1e-15 57.9 0.1 3.3e-15 56.2 0.0 2.0 2 0 0 2 2 2 1 C2 domain eIF3_p135 PF12807.7 ELR22968.1 - 1e-07 32.2 0.0 2.2e-07 31.1 0.0 1.5 1 0 0 1 1 1 1 Translation initiation factor eIF3 subunit 135 TPR_11 PF13414.6 ELR22968.1 - 1.9 8.2 9.0 2.4 7.9 0.0 3.1 4 0 0 4 4 4 0 TPR repeat HEAT_EZ PF13513.6 ELR22969.1 - 0.0021 18.5 0.1 0.0063 17.0 0.1 1.8 1 0 0 1 1 1 1 HEAT-like repeat Drf_GBD PF06371.13 ELR22969.1 - 0.019 14.6 0.0 0.035 13.7 0.0 1.4 1 0 0 1 1 1 0 Diaphanous GTPase-binding Domain DUF4290 PF14123.6 ELR22969.1 - 0.062 12.8 0.3 0.18 11.4 0.1 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4290) CENP-Q PF13094.6 ELR22970.1 - 0.0091 16.2 1.6 0.0091 16.2 1.6 2.5 2 0 0 2 2 2 1 CENP-Q, a CENPA-CAD centromere complex subunit Casc1 PF12366.8 ELR22970.1 - 3.3 7.2 8.7 1.2 8.6 0.7 2.9 2 1 0 2 2 2 0 Cancer susceptibility candidate 1 AAA_23 PF13476.6 ELR22970.1 - 9.7 6.6 19.6 12 6.3 3.4 2.2 2 0 0 2 2 2 0 AAA domain FR47 PF08445.10 ELR22971.1 - 2.9e-09 36.8 0.1 4.6e-07 29.7 0.1 2.5 1 1 0 1 1 1 1 FR47-like protein Gly_acyl_tr_C PF08444.10 ELR22971.1 - 2e-05 24.7 0.0 0.00011 22.3 0.0 2.0 1 1 0 1 1 1 1 Aralkyl acyl-CoA:amino acid N-acyltransferase, C-terminal region Acetyltransf_3 PF13302.7 ELR22971.1 - 0.0023 18.6 0.0 0.0041 17.8 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain GNAT_acetyltran PF12746.7 ELR22971.1 - 0.048 13.2 0.0 4.7 6.7 0.0 2.8 3 0 0 3 3 3 0 GNAT acetyltransferase Acetyltransf_10 PF13673.7 ELR22971.1 - 0.055 13.4 0.0 0.19 11.7 0.0 1.9 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 ELR22971.1 - 0.091 13.2 0.0 0.18 12.3 0.0 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Type_III_YscX PF09474.10 ELR22971.1 - 0.14 12.5 0.1 0.25 11.7 0.1 1.3 1 0 0 1 1 1 0 Type III secretion system YscX (type_III_YscX) Acetyltransf_CG PF14542.6 ELR22971.1 - 0.15 12.2 0.0 0.36 11.0 0.0 1.6 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase Acetyltransf_1 PF00583.25 ELR22971.1 - 0.18 12.0 0.0 0.63 10.3 0.0 1.9 2 0 0 2 2 2 0 Acetyltransferase (GNAT) family AFG1_ATPase PF03969.16 ELR22972.1 - 2.6e-86 289.8 0.0 2.1e-51 174.9 0.0 3.1 1 1 1 2 2 2 2 AFG1-like ATPase ATPase_2 PF01637.18 ELR22972.1 - 0.00022 21.2 0.0 0.0059 16.6 0.0 2.1 2 0 0 2 2 2 1 ATPase domain predominantly from Archaea AAA_16 PF13191.6 ELR22972.1 - 0.00096 19.6 0.1 0.012 16.0 0.1 2.5 2 1 0 2 2 2 1 AAA ATPase domain Bac_DnaA PF00308.18 ELR22972.1 - 0.0015 18.4 0.0 0.62 9.9 0.0 3.0 3 0 0 3 3 3 1 Bacterial dnaA protein AAA PF00004.29 ELR22972.1 - 0.0027 18.1 0.0 0.25 11.8 0.0 3.0 3 0 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 ELR22972.1 - 0.015 15.6 0.0 0.03 14.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain TsaE PF02367.17 ELR22972.1 - 0.08 12.9 0.0 0.15 12.1 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE RabGAP-TBC PF00566.18 ELR22974.1 - 4.4e-39 134.4 0.0 8.8e-39 133.4 0.0 1.5 1 0 0 1 1 1 1 Rab-GTPase-TBC domain GRAM PF02893.20 ELR22974.1 - 3.4e-27 94.6 0.0 5.2e-16 58.5 0.1 2.4 2 0 0 2 2 2 2 GRAM domain Sporozoite_P67 PF05642.11 ELR22974.1 - 0.67 8.0 11.3 0.11 10.5 3.6 2.1 2 0 0 2 2 2 0 Sporozoite P67 surface antigen Thioredoxin_7 PF13899.6 ELR22975.1 - 8e-18 64.4 0.0 1.2e-17 63.9 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin-like Thioredox_DsbH PF03190.15 ELR22975.1 - 1.3e-08 34.9 0.0 1.7e-08 34.6 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function, DUF255 Thioredoxin PF00085.20 ELR22975.1 - 6.3e-07 29.3 0.0 8.5e-07 28.9 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.6 ELR22975.1 - 6.8e-06 26.5 0.0 9.8e-06 26.0 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin-like domain AhpC-TSA PF00578.21 ELR22975.1 - 0.013 15.4 0.1 0.025 14.5 0.1 1.5 1 1 0 1 1 1 0 AhpC/TSA family Thioredoxin_8 PF13905.6 ELR22975.1 - 0.019 15.3 0.0 0.3 11.4 0.0 2.1 1 1 1 2 2 2 0 Thioredoxin-like Thioredoxin_9 PF14595.6 ELR22975.1 - 0.032 14.0 0.0 0.044 13.6 0.0 1.2 1 0 0 1 1 1 0 Thioredoxin WD40 PF00400.32 ELR22976.1 - 1.3e-61 203.0 19.5 8.4e-11 42.3 0.8 7.5 7 0 0 7 7 7 7 WD domain, G-beta repeat Tup_N PF08581.10 ELR22976.1 - 9.6e-24 83.5 5.2 1.5e-23 82.8 5.2 1.2 1 0 0 1 1 1 1 Tup N-terminal ANAPC4_WD40 PF12894.7 ELR22976.1 - 2.9e-23 82.0 0.0 0.001 19.3 0.0 7.7 2 1 6 8 8 8 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ELR22976.1 - 1.6e-10 40.5 0.7 0.29 10.1 0.1 6.2 2 2 4 6 6 6 4 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ELR22976.1 - 1.1e-08 34.8 0.0 0.073 12.4 0.0 5.1 5 0 0 5 5 5 2 WD40-like domain Cytochrom_D1 PF02239.16 ELR22976.1 - 0.00024 19.7 0.1 0.037 12.6 0.1 2.7 2 1 1 3 3 3 1 Cytochrome D1 heme domain Nbas_N PF15492.6 ELR22976.1 - 0.00037 19.9 0.1 2.2 7.6 0.0 3.7 2 1 2 4 4 4 2 Neuroblastoma-amplified sequence, N terminal PD40 PF07676.12 ELR22976.1 - 0.0019 18.1 7.1 4.2 7.4 0.1 5.6 6 0 0 6 6 6 2 WD40-like Beta Propeller Repeat Frtz PF11768.8 ELR22976.1 - 0.0068 14.8 0.0 3.9 5.7 0.0 3.2 3 1 1 4 4 4 2 WD repeat-containing and planar cell polarity effector protein Fritz Nup160 PF11715.8 ELR22976.1 - 0.0079 14.9 0.0 25 3.3 0.0 4.0 1 1 2 4 4 4 0 Nucleoporin Nup120/160 CENP-Q PF13094.6 ELR22976.1 - 0.011 15.9 1.2 0.013 15.7 0.1 1.6 2 0 0 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit DUF5122 PF17164.4 ELR22976.1 - 6.2 7.2 8.3 23 5.4 0.0 4.5 6 0 0 6 6 6 0 Domain of unknown function (DUF5122) beta-propeller Myb_DNA-binding PF00249.31 ELR22978.1 - 9.9e-09 35.3 0.1 3.2e-08 33.6 0.0 1.9 2 0 0 2 2 2 1 Myb-like DNA-binding domain TFIIA PF03153.13 ELR22978.1 - 0.001 19.2 8.8 0.001 19.2 8.8 3.4 2 1 1 3 3 3 1 Transcription factor IIA, alpha/beta subunit EVI2A PF05399.11 ELR22978.1 - 1.5 8.4 5.3 4.3 6.9 5.3 1.7 1 0 0 1 1 1 0 Ectropic viral integration site 2A protein (EVI2A) CLN3 PF02487.17 ELR22978.1 - 5.1 6.0 6.1 0.41 9.6 0.5 1.9 2 0 0 2 2 2 0 CLN3 protein MCU PF04678.13 ELR22979.1 - 1.5e-44 152.2 0.9 1.8e-44 151.9 0.9 1.1 1 0 0 1 1 1 1 Mitochondrial calcium uniporter COR PF16095.5 ELR22979.1 - 4.7e-06 26.5 0.0 9e-06 25.6 0.0 1.6 1 0 0 1 1 1 1 C-terminal of Roc, COR, domain Phasin PF05597.11 ELR22979.1 - 0.057 13.4 1.0 0.8 9.7 0.0 2.5 1 1 1 2 2 2 0 Poly(hydroxyalcanoate) granule associated protein (phasin) Csm1_N PF18504.1 ELR22979.1 - 0.084 13.2 1.2 0.22 11.9 1.2 1.7 1 0 0 1 1 1 0 Csm1 N-terminal domain Ligase_CoA PF00549.19 ELR22980.1 - 5.1e-24 84.8 0.3 7e-24 84.4 0.3 1.2 1 0 0 1 1 1 1 CoA-ligase CoA_binding PF02629.19 ELR22980.1 - 2e-09 38.0 1.1 5.4e-09 36.6 1.1 1.8 1 0 0 1 1 1 1 CoA binding domain Succ_CoA_lig PF13607.6 ELR22980.1 - 3.4e-09 36.6 0.0 7.3e-09 35.5 0.0 1.6 2 0 0 2 2 2 1 Succinyl-CoA ligase like flavodoxin domain PQQ_2 PF13360.6 ELR22981.1 - 0.016 14.8 1.5 0.17 11.4 0.5 2.4 2 0 0 2 2 2 0 PQQ-like domain PQQ PF01011.21 ELR22981.1 - 0.05 13.6 0.6 1.1 9.4 0.1 2.9 3 0 0 3 3 3 0 PQQ enzyme repeat dUTPase PF00692.19 ELR22982.1 - 8.9e-27 93.3 0.0 9.8e-27 93.2 0.0 1.0 1 0 0 1 1 1 1 dUTPase mRNA_cap_enzyme PF01331.19 ELR22985.1 - 4.5e-18 65.8 0.0 1.6e-08 34.6 0.0 2.8 2 1 0 2 2 2 2 mRNA capping enzyme, catalytic domain mRNA_cap_C PF03919.15 ELR22985.1 - 1.4e-11 45.0 0.1 3.7e-11 43.6 0.1 1.8 1 1 0 1 1 1 1 mRNA capping enzyme, C-terminal domain DNA_ligase_A_M PF01068.21 ELR22985.1 - 1.5e-07 31.2 0.0 1.2e-05 25.0 0.0 2.5 2 0 0 2 2 2 1 ATP dependent DNA ligase domain RNA_ligase PF09414.10 ELR22985.1 - 0.0011 19.3 0.0 0.0021 18.4 0.0 1.5 1 0 0 1 1 1 1 RNA ligase TBCA PF02970.16 ELR22986.1 - 1e-23 83.4 11.0 1.3e-23 83.1 11.0 1.1 1 0 0 1 1 1 1 Tubulin binding cofactor A FapA PF03961.13 ELR22986.1 - 0.022 13.4 8.5 0.023 13.3 8.5 1.0 1 0 0 1 1 1 0 Flagellar Assembly Protein A DUF1699 PF08004.11 ELR22986.1 - 0.039 13.6 1.2 0.065 12.9 1.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1699) Striatin PF08232.12 ELR22986.1 - 0.072 13.7 9.0 0.083 13.5 9.0 1.0 1 0 0 1 1 1 0 Striatin family AbiGi PF10899.8 ELR22986.1 - 0.086 12.7 0.1 0.14 12.0 0.1 1.3 1 1 0 1 1 1 0 Putative abortive phage resistance protein AbiGi, antitoxin Dynamitin PF04912.14 ELR22986.1 - 0.093 12.0 8.9 0.11 11.8 8.9 1.1 1 0 0 1 1 1 0 Dynamitin GIT_CC PF16559.5 ELR22986.1 - 0.1 12.4 3.4 0.14 12.0 2.2 1.8 2 0 0 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor Nsp1_C PF05064.13 ELR22986.1 - 0.12 12.1 6.7 0.16 11.8 6.7 1.2 1 0 0 1 1 1 0 Nsp1-like C-terminal region Allexi_40kDa PF05549.11 ELR22986.1 - 0.16 11.5 3.4 0.19 11.2 3.4 1.0 1 0 0 1 1 1 0 Allexivirus 40kDa protein DUF4878 PF12870.7 ELR22986.1 - 0.2 12.0 3.8 0.37 11.1 3.8 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4878) Cauli_AT PF03233.13 ELR22986.1 - 0.26 11.2 4.3 0.21 11.5 2.7 1.5 1 1 1 2 2 2 0 Aphid transmission protein Fmp27_WPPW PF10359.9 ELR22986.1 - 0.94 8.2 8.2 1 8.1 8.2 1.0 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain APG6_N PF17675.1 ELR22986.1 - 2 9.0 14.1 2.5 8.6 14.1 1.2 1 0 0 1 1 1 0 Apg6 coiled-coil region Spc7 PF08317.11 ELR22986.1 - 2.1 7.1 13.3 0.66 8.8 2.5 1.9 1 1 1 2 2 2 0 Spc7 kinetochore protein TMPIT PF07851.13 ELR22986.1 - 2.5 7.3 6.2 2.6 7.2 6.2 1.1 1 0 0 1 1 1 0 TMPIT-like protein UPF0242 PF06785.11 ELR22986.1 - 2.5 8.2 11.3 3.3 7.8 11.3 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus WHEP-TRS PF00458.20 ELR22986.1 - 9.2 6.5 7.9 17 5.6 0.5 2.6 3 1 0 3 3 3 0 WHEP-TRS domain Glycos_transf_1 PF00534.20 ELR22987.1 - 5.7e-28 97.6 0.0 8.5e-26 90.5 0.0 2.4 1 1 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 ELR22987.1 - 9.8e-15 55.0 0.3 2e-14 54.0 0.3 1.6 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_trans_1_4 PF13692.6 ELR22987.1 - 2.4e-13 50.7 0.0 5.6e-13 49.5 0.0 1.6 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.6 ELR22987.1 - 5.5e-09 36.7 0.2 5.2e-08 33.5 0.2 2.2 1 1 1 2 2 2 1 Glycosyl transferase 4-like domain Glyco_trans_1_2 PF13524.6 ELR22987.1 - 0.00047 20.5 0.1 0.0013 19.1 0.1 1.8 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_4_5 PF16994.5 ELR22987.1 - 0.011 15.3 0.0 0.43 10.2 0.0 2.3 2 0 0 2 2 2 0 Glycosyl-transferase family 4 DHFR_1 PF00186.19 ELR22987.1 - 0.16 11.7 0.0 0.28 10.9 0.0 1.4 1 0 0 1 1 1 0 Dihydrofolate reductase ubiquitin PF00240.23 ELR22988.1 - 2.7e-06 27.0 0.0 8e-06 25.5 0.0 1.7 1 1 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 ELR22988.1 - 0.023 14.5 0.0 0.23 11.3 0.0 2.2 1 1 1 2 2 2 0 Ubiquitin-2 like Rad60 SUMO-like Ribosomal_S8e PF01201.22 ELR22989.1 - 9.9e-43 145.6 7.7 2.3e-42 144.4 7.6 1.6 1 1 0 1 1 1 1 Ribosomal protein S8e Acid_phosphat_B PF03767.14 ELR22989.1 - 0.036 13.6 0.9 0.048 13.2 0.9 1.3 1 0 0 1 1 1 0 HAD superfamily, subfamily IIIB (Acid phosphatase) zf-CCCH PF00642.24 ELR22990.1 - 0.00012 21.9 2.9 0.00021 21.1 2.9 1.4 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) FTA2 PF13095.6 ELR22990.1 - 0.046 13.3 0.0 0.088 12.4 0.0 1.4 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 GHMP_kinases_C PF08544.13 ELR22991.1 - 5.7e-06 26.6 0.0 1e-05 25.8 0.0 1.5 1 0 0 1 1 1 1 GHMP kinases C terminal Thr_synth_N PF14821.6 ELR22992.1 - 5.9e-29 100.1 0.0 2e-28 98.4 0.0 2.0 1 0 0 1 1 1 1 Threonine synthase N terminus PALP PF00291.25 ELR22992.1 - 8.9e-10 38.5 0.0 2.6e-08 33.7 0.0 2.4 1 1 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme DUF1196 PF06709.11 ELR22992.1 - 0.13 12.4 1.2 0.31 11.2 0.1 2.2 3 0 0 3 3 3 0 Protein of unknown function (DUF1196) RSN1_7TM PF02714.15 ELR22993.1 - 1.3e-38 132.9 27.1 1.3e-38 132.9 27.1 1.9 2 0 0 2 2 2 1 Calcium-dependent channel, 7TM region, putative phosphate RSN1_TM PF13967.6 ELR22993.1 - 4.6e-24 84.9 5.4 1.7e-22 79.9 0.1 3.6 3 0 0 3 3 3 2 Late exocytosis, associated with Golgi transport PHM7_cyt PF14703.6 ELR22993.1 - 2.7e-14 53.8 0.7 7.3e-11 42.6 1.6 2.8 2 1 0 2 2 2 2 Cytosolic domain of 10TM putative phosphate transporter Anoctamin PF04547.12 ELR22993.1 - 4e-05 22.6 14.5 4e-05 22.6 14.5 2.0 2 0 0 2 2 2 1 Calcium-activated chloride channel RskA PF10099.9 ELR22993.1 - 1.4 9.2 7.7 1.9 8.8 2.3 3.2 3 1 1 4 4 4 0 Anti-sigma-K factor rskA YbaB_DNA_bd PF02575.16 ELR22994.1 - 4.8e-05 23.5 0.3 0.00069 19.8 0.1 1.9 1 1 1 2 2 2 1 YbaB/EbfC DNA-binding family Adaptin_binding PF10199.9 ELR22995.1 - 1.7e-12 48.0 15.6 5.2e-12 46.4 15.6 1.8 1 1 0 1 1 1 1 Alpha and gamma adaptin binding protein p34 Methyltransf_16 PF10294.9 ELR22996.1 - 3e-21 75.9 0.1 5e-21 75.2 0.1 1.3 1 0 0 1 1 1 1 Lysine methyltransferase Methyltransf_25 PF13649.6 ELR22996.1 - 0.0012 19.5 0.0 0.0035 18.0 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 ELR22996.1 - 0.0038 17.1 0.1 0.029 14.2 0.0 2.5 2 1 1 3 3 3 1 Methyltransferase domain NNMT_PNMT_TEMT PF01234.17 ELR22996.1 - 0.0043 16.3 0.0 0.0067 15.7 0.0 1.3 1 0 0 1 1 1 1 NNMT/PNMT/TEMT family Cons_hypoth95 PF03602.15 ELR22996.1 - 0.008 15.8 0.0 0.017 14.8 0.0 1.5 1 0 0 1 1 1 1 Conserved hypothetical protein 95 PCMT PF01135.19 ELR22996.1 - 0.013 15.3 0.0 0.038 13.8 0.0 1.7 1 1 1 2 2 2 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) PrmA PF06325.13 ELR22996.1 - 0.022 14.2 0.0 0.043 13.2 0.0 1.4 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Peptidase_M41 PF01434.18 ELR22998.1 - 0.057 13.3 0.3 0.057 13.3 0.3 2.3 2 0 0 2 2 2 0 Peptidase family M41 DUF4148 PF13663.6 ELR22998.1 - 3 8.1 6.1 1.8 8.8 2.6 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF4148) Dynamin_N PF00350.23 ELR22999.1 - 2.3e-11 44.1 0.1 8.5e-11 42.2 0.0 2.1 2 0 0 2 2 2 1 Dynamin family MMR_HSR1 PF01926.23 ELR22999.1 - 5e-05 23.4 0.0 0.00015 21.8 0.0 1.9 1 1 0 1 1 1 1 50S ribosome-binding GTPase ABC_tran PF00005.27 ELR22999.1 - 0.0022 18.5 0.1 0.027 15.0 0.0 2.8 3 1 0 3 3 3 1 ABC transporter CCDC-167 PF15188.6 ELR22999.1 - 0.0042 17.4 4.3 0.56 10.6 0.9 2.9 2 0 0 2 2 2 2 Coiled-coil domain-containing protein 167 AAA_16 PF13191.6 ELR22999.1 - 0.0049 17.3 0.1 0.033 14.6 0.0 2.5 2 0 0 2 2 2 1 AAA ATPase domain AAA_33 PF13671.6 ELR22999.1 - 0.0049 17.0 0.0 0.015 15.4 0.0 1.9 1 0 0 1 1 1 1 AAA domain AAA_28 PF13521.6 ELR22999.1 - 0.0057 16.9 0.0 0.018 15.3 0.0 1.9 1 0 0 1 1 1 1 AAA domain RsgA_GTPase PF03193.16 ELR22999.1 - 0.0062 16.5 0.0 0.019 14.9 0.0 1.8 2 0 0 2 2 2 1 RsgA GTPase AAA_22 PF13401.6 ELR22999.1 - 0.0085 16.4 0.0 0.074 13.3 0.0 2.7 2 0 0 2 2 2 1 AAA domain GTP_EFTU PF00009.27 ELR22999.1 - 0.011 15.3 0.0 0.085 12.4 0.0 2.4 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain AAA_23 PF13476.6 ELR22999.1 - 0.015 15.8 1.2 0.14 12.6 1.2 2.7 1 1 0 1 1 1 0 AAA domain AAA PF00004.29 ELR22999.1 - 0.036 14.5 0.0 0.41 11.1 0.0 2.5 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_29 PF13555.6 ELR22999.1 - 0.058 13.1 0.0 0.13 12.0 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain cobW PF02492.19 ELR22999.1 - 0.072 12.7 0.0 0.13 11.8 0.0 1.4 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA_14 PF13173.6 ELR22999.1 - 0.074 13.1 0.0 0.42 10.6 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_7 PF12775.7 ELR22999.1 - 0.15 11.6 0.0 0.4 10.2 0.0 1.6 1 0 0 1 1 1 0 P-loop containing dynein motor region PduV-EutP PF10662.9 ELR22999.1 - 0.2 11.4 0.0 1.9 8.2 0.0 2.7 4 0 0 4 4 4 0 Ethanolamine utilisation - propanediol utilisation Malate_synthase PF01274.22 ELR23000.1 - 2e-206 686.3 0.0 2.3e-206 686.2 0.0 1.0 1 0 0 1 1 1 1 Malate synthase HpcH_HpaI PF03328.14 ELR23000.1 - 0.0067 15.6 0.0 0.026 13.6 0.0 2.0 2 0 0 2 2 2 1 HpcH/HpaI aldolase/citrate lyase family Pribosyltran PF00156.27 ELR23001.1 - 1.8e-11 43.8 0.3 2.8e-11 43.2 0.3 1.3 1 0 0 1 1 1 1 Phosphoribosyl transferase domain UPRTase PF14681.6 ELR23001.1 - 0.0044 16.5 0.0 0.0057 16.1 0.0 1.2 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase PRTase_2 PF15609.6 ELR23001.1 - 0.19 11.2 0.0 0.29 10.6 0.0 1.2 1 0 0 1 1 1 0 Phosphoribosyl transferase Ras PF00071.22 ELR23002.1 - 4e-36 124.1 2.2 4e-27 94.8 0.3 2.1 1 1 1 2 2 2 2 Ras family Roc PF08477.13 ELR23002.1 - 3.3e-20 72.5 0.1 5.3e-20 71.8 0.1 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR23002.1 - 3.6e-07 29.8 0.2 3e-06 26.8 0.1 1.9 1 1 1 2 2 2 1 ADP-ribosylation factor family SRPRB PF09439.10 ELR23002.1 - 6.4e-07 29.0 0.2 1.3e-06 28.0 0.1 1.5 2 0 0 2 2 2 1 Signal recognition particle receptor beta subunit GTP_EFTU PF00009.27 ELR23002.1 - 0.00029 20.4 0.4 0.018 14.6 0.1 2.6 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 ELR23002.1 - 0.001 19.1 0.0 0.0016 18.5 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_16 PF13191.6 ELR23002.1 - 0.0017 18.7 0.1 0.0026 18.1 0.0 1.3 1 1 0 1 1 1 1 AAA ATPase domain AAA_24 PF13479.6 ELR23002.1 - 0.0019 18.0 0.1 0.09 12.5 0.0 2.6 2 1 0 2 2 2 1 AAA domain RsgA_GTPase PF03193.16 ELR23002.1 - 0.0034 17.3 0.1 0.13 12.2 0.0 2.1 2 0 0 2 2 2 1 RsgA GTPase Gtr1_RagA PF04670.12 ELR23002.1 - 0.0083 15.5 0.0 0.011 15.1 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region FeoB_N PF02421.18 ELR23002.1 - 0.14 11.7 0.0 4 7.0 0.0 2.2 1 1 1 2 2 2 0 Ferrous iron transport protein B NACHT PF05729.12 ELR23002.1 - 0.29 11.0 0.0 0.29 11.0 0.0 2.0 2 0 0 2 2 2 0 NACHT domain Ras PF00071.22 ELR23003.1 - 1.1e-42 145.4 0.2 1.5e-42 145.0 0.2 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR23003.1 - 2.9e-23 82.4 0.2 4.3e-23 81.8 0.2 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR23003.1 - 1.3e-09 37.8 0.1 1.6e-09 37.5 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 ELR23003.1 - 0.0045 16.5 0.3 0.0084 15.7 0.1 1.6 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 ELR23003.1 - 0.0054 16.1 0.2 0.0073 15.7 0.2 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.10 ELR23003.1 - 0.014 14.8 0.0 0.026 14.0 0.0 1.3 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit Amino_oxidase PF01593.24 ELR23004.1 - 3.3e-55 188.2 0.4 1.4e-53 182.8 0.4 2.0 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 ELR23004.1 - 9.2e-06 25.8 0.8 3.4e-05 24.0 0.0 2.3 3 0 0 3 3 3 1 NAD(P)-binding Rossmann-like domain Ribosomal_60s PF00428.19 ELR23005.1 - 2.2e-16 60.2 8.5 2.9e-16 59.8 8.5 1.2 1 0 0 1 1 1 1 60s Acidic ribosomal protein Sigma70_ner PF04546.13 ELR23005.1 - 0.082 12.8 0.1 0.1 12.4 0.1 1.1 1 0 0 1 1 1 0 Sigma-70, non-essential region TctA PF01970.16 ELR23005.1 - 0.13 10.9 0.1 0.15 10.8 0.1 1.1 1 0 0 1 1 1 0 Tripartite tricarboxylate transporter TctA family DUF3235 PF11574.8 ELR23005.1 - 0.45 11.4 10.8 2.8 8.9 0.0 2.1 1 1 0 2 2 2 0 Protein of unknown function (DUF3235) Ank_2 PF12796.7 ELR23006.1 - 1.8e-20 73.3 0.0 5.4e-09 36.5 0.0 4.4 3 1 0 4 4 4 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ELR23006.1 - 5.4e-14 52.3 0.0 0.0095 16.5 0.0 5.8 4 2 1 5 5 5 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 ELR23006.1 - 9.2e-14 50.2 0.1 0.02 15.4 0.0 6.2 8 0 0 8 8 8 4 Ankyrin repeat Ank_5 PF13857.6 ELR23006.1 - 6.3e-13 48.7 1.4 0.00088 19.5 0.0 5.8 5 1 1 6 6 6 2 Ankyrin repeats (many copies) Ank PF00023.30 ELR23006.1 - 4.3e-10 39.6 0.4 0.31 11.6 0.0 6.0 6 0 0 6 6 6 3 Ankyrin repeat F-box-like PF12937.7 ELR23006.1 - 5e-07 29.5 0.5 5e-07 29.5 0.5 2.3 2 0 0 2 2 2 1 F-box-like F-box_4 PF15966.5 ELR23006.1 - 0.00056 19.8 0.0 0.001 18.9 0.0 1.4 1 0 0 1 1 1 1 F-box F-box PF00646.33 ELR23006.1 - 0.0039 17.0 0.2 0.0078 16.1 0.2 1.5 1 0 0 1 1 1 1 F-box domain Elongin_A PF06881.11 ELR23006.1 - 0.01 16.3 0.0 0.018 15.6 0.0 1.3 1 0 0 1 1 1 0 RNA polymerase II transcription factor SIII (Elongin) subunit A Ribosomal_L7Ae PF01248.26 ELR23007.1 - 9.6e-25 86.2 0.7 1.6e-24 85.4 0.7 1.4 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family RNase_P_pop3 PF08228.11 ELR23007.1 - 3e-05 24.1 0.0 3.9e-05 23.8 0.0 1.1 1 0 0 1 1 1 1 RNase P subunit Pop3 DUF2332 PF10094.9 ELR23008.1 - 0.055 12.9 0.1 0.072 12.5 0.1 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2332) JmjC PF02373.22 ELR23009.1 - 4.2e-21 75.5 1.1 7.1e-21 74.8 0.1 1.9 2 0 0 2 2 2 1 JmjC domain, hydroxylase Cupin_8 PF13621.6 ELR23009.1 - 4.9e-16 59.2 2.1 8.3e-16 58.5 2.1 1.3 1 0 0 1 1 1 1 Cupin-like domain UPF0020 PF01170.18 ELR23010.1 - 2.6e-22 79.5 0.0 4.2e-22 78.8 0.0 1.3 1 0 0 1 1 1 1 Putative RNA methylase family UPF0020 SGL PF08450.12 ELR23011.1 - 1.9e-84 283.1 0.1 2.2e-84 282.9 0.1 1.0 1 0 0 1 1 1 1 SMP-30/Gluconolactonase/LRE-like region Reg_prop PF07494.11 ELR23011.1 - 0.0014 18.6 0.7 0.94 9.9 0.0 3.3 2 1 0 2 2 2 2 Two component regulator propeller Arylesterase PF01731.20 ELR23011.1 - 0.027 14.7 0.0 0.096 12.9 0.0 2.0 3 0 0 3 3 3 0 Arylesterase DUF5122 PF17164.4 ELR23011.1 - 0.048 14.0 0.3 9.5 6.6 0.1 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF5122) beta-propeller Lactonase PF10282.9 ELR23011.1 - 0.11 11.7 0.0 0.15 11.3 0.0 1.2 1 0 0 1 1 1 0 Lactonase, 7-bladed beta-propeller PQ-loop PF04193.14 ELR23012.1 - 3.1e-16 58.9 12.2 5.1e-09 35.8 2.0 2.8 2 0 0 2 2 2 2 PQ loop repeat UPF0259 PF06790.11 ELR23013.1 - 0.048 13.4 3.4 0.097 12.4 3.4 1.4 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0259) SSB PF00436.25 ELR23014.1 - 3.7e-26 91.2 0.1 5.3e-26 90.7 0.1 1.2 1 0 0 1 1 1 1 Single-strand binding protein family DUF3217 PF11506.8 ELR23014.1 - 0.094 12.7 0.3 1.9 8.5 0.2 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3217) RNase_PH PF01138.21 ELR23015.1 - 2.7e-34 118.5 0.0 4e-34 118.0 0.0 1.3 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 ELR23015.1 - 1.7e-08 34.4 0.2 3.8e-08 33.3 0.2 1.6 1 0 0 1 1 1 1 3' exoribonuclease family, domain 2 SET PF00856.28 ELR23016.1 - 7.9e-11 42.6 0.0 1.7e-10 41.6 0.0 1.7 1 1 0 1 1 1 1 SET domain zf-MYND PF01753.18 ELR23016.1 - 0.0027 17.7 6.0 0.0027 17.7 6.0 2.6 2 0 0 2 2 2 1 MYND finger zf-UBP_var PF17807.1 ELR23016.1 - 0.012 15.3 1.5 0.064 13.0 0.9 2.3 2 0 0 2 2 2 0 Variant UBP zinc finger SAP PF02037.27 ELR23017.1 - 7.5e-09 35.1 0.2 1.3e-08 34.4 0.2 1.4 1 0 0 1 1 1 1 SAP domain PEHE PF15275.6 ELR23017.1 - 9.1e-09 36.0 1.9 1.7e-08 35.1 1.9 1.4 1 0 0 1 1 1 1 PEHE domain DUF5555 PF17710.1 ELR23017.1 - 0.01 15.4 1.1 0.014 15.0 1.1 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5555) RXT2_N PF08595.11 ELR23017.1 - 0.071 13.1 1.8 0.1 12.6 1.8 1.2 1 0 0 1 1 1 0 RXT2-like, N-terminal DNA_pol_phi PF04931.13 ELR23017.1 - 0.2 9.7 7.4 0.25 9.4 7.4 1.0 1 0 0 1 1 1 0 DNA polymerase phi Cwf_Cwc_15 PF04889.12 ELR23017.1 - 0.21 11.3 6.9 0.27 10.9 6.9 1.1 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Spt5_N PF11942.8 ELR23017.1 - 0.69 10.9 16.0 0.095 13.7 11.7 1.7 2 0 0 2 2 2 0 Spt5 transcription elongation factor, acidic N-terminal DUF2457 PF10446.9 ELR23017.1 - 0.7 9.0 10.1 0.96 8.5 10.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) CDC45 PF02724.14 ELR23017.1 - 0.75 8.0 4.7 0.83 7.9 4.7 1.0 1 0 0 1 1 1 0 CDC45-like protein NOA36 PF06524.12 ELR23017.1 - 1.2 8.3 8.4 1.6 8.0 8.4 1.1 1 0 0 1 1 1 0 NOA36 protein Pes-10 PF07149.11 ELR23017.1 - 5.3 6.0 5.9 6.6 5.7 5.9 1.1 1 0 0 1 1 1 0 Pes-10 Sulfatase PF00884.23 ELR23018.1 - 1.1e-13 51.3 0.5 1.6e-13 50.8 0.5 1.2 1 0 0 1 1 1 1 Sulfatase DUF3413 PF11893.8 ELR23018.1 - 0.015 14.5 1.6 0.037 13.2 1.6 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3413) DUF229 PF02995.17 ELR23018.1 - 0.055 12.1 0.1 0.08 11.5 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF229) Urb2 PF10441.9 ELR23019.1 - 5.7e-23 81.9 0.1 5.7e-23 81.9 0.1 3.8 4 0 0 4 4 4 1 Urb2/Npa2 family SR-25 PF10500.9 ELR23019.1 - 6.5 6.3 10.5 1.2 8.7 4.1 2.4 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein OCC1 PF15506.6 ELR23019.1 - 8.7 6.6 6.7 4.4 7.5 0.1 3.4 3 0 0 3 3 3 0 OCC1 family Glyco_hydro_20 PF00728.22 ELR23020.1 - 1.5e-81 274.5 7.6 3.2e-58 197.8 0.0 2.1 2 0 0 2 2 2 2 Glycosyl hydrolase family 20, catalytic domain Glycohydro_20b2 PF14845.6 ELR23020.1 - 4.1e-14 53.4 0.0 4.5e-13 50.0 0.0 2.5 2 1 0 2 2 2 1 beta-acetyl hexosaminidase like Glyco_hydro_20b PF02838.15 ELR23020.1 - 0.058 14.2 0.0 0.098 13.4 0.0 1.3 1 0 0 1 1 1 0 Glycosyl hydrolase family 20, domain 2 GRAM PF02893.20 ELR23021.1 - 9.9e-11 41.5 0.1 1.7e-10 40.8 0.1 1.3 1 0 0 1 1 1 1 GRAM domain CC2-LZ PF16516.5 ELR23021.1 - 0.19 12.1 11.6 0.48 10.8 11.6 1.6 1 1 0 1 1 1 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator V_ATPase_I PF01496.19 ELR23021.1 - 0.35 8.7 6.2 0.47 8.3 6.2 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Atg14 PF10186.9 ELR23021.1 - 0.38 9.8 11.5 0.58 9.2 11.5 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 UPF0242 PF06785.11 ELR23021.1 - 3 7.9 9.8 5.1 7.1 9.8 1.4 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus FapA PF03961.13 ELR23021.1 - 3.6 6.1 4.8 6.7 5.2 4.6 1.5 1 1 0 1 1 1 0 Flagellar Assembly Protein A PIF1 PF05970.14 ELR23022.1 - 1.7e-56 192.0 0.3 1.1e-54 186.0 0.3 2.3 1 1 0 1 1 1 1 PIF1-like helicase AAA_30 PF13604.6 ELR23022.1 - 6.2e-16 58.7 0.0 1.6e-15 57.3 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 ELR23022.1 - 7.6e-09 36.1 0.3 8e-08 32.7 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 ELR23022.1 - 2.5e-06 27.8 0.0 1.1e-05 25.7 0.0 2.1 1 0 0 1 1 1 1 AAA domain CUE PF02845.16 ELR23022.1 - 3.5e-05 23.4 0.0 7.6e-05 22.3 0.0 1.5 1 0 0 1 1 1 1 CUE domain Caldesmon PF02029.15 ELR23022.1 - 6.6e-05 21.9 24.8 0.0001 21.3 24.8 1.2 1 0 0 1 1 1 1 Caldesmon AAA PF00004.29 ELR23022.1 - 0.00024 21.5 0.1 0.00063 20.2 0.1 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 ELR23022.1 - 0.0044 17.4 0.1 0.017 15.5 0.1 2.0 1 0 0 1 1 1 1 AAA ATPase domain Mg_chelatase PF01078.21 ELR23022.1 - 0.0066 15.9 0.0 0.013 14.8 0.0 1.4 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_24 PF13479.6 ELR23022.1 - 0.0071 16.1 1.8 0.014 15.1 0.0 2.3 3 0 0 3 3 3 1 AAA domain AAA_5 PF07728.14 ELR23022.1 - 0.0082 16.2 1.4 0.012 15.6 0.1 2.0 2 1 0 2 2 1 1 AAA domain (dynein-related subfamily) AAA_14 PF13173.6 ELR23022.1 - 0.012 15.6 0.0 0.038 14.0 0.0 1.8 1 0 0 1 1 1 0 AAA domain Herpes_Helicase PF02689.14 ELR23022.1 - 0.019 12.9 0.0 0.43 8.4 0.0 2.1 2 0 0 2 2 2 0 Helicase AAA_7 PF12775.7 ELR23022.1 - 0.028 14.0 0.0 0.11 12.0 0.0 1.9 2 0 0 2 2 2 0 P-loop containing dynein motor region UvrD_C_2 PF13538.6 ELR23022.1 - 0.047 13.5 0.0 0.11 12.3 0.0 1.6 1 0 0 1 1 1 0 UvrD-like helicase C-terminal domain PhoH PF02562.16 ELR23022.1 - 0.067 12.6 0.0 0.17 11.3 0.0 1.6 2 0 0 2 2 2 0 PhoH-like protein AAA_29 PF13555.6 ELR23022.1 - 0.17 11.7 0.5 0.45 10.3 0.0 1.9 2 0 0 2 2 2 0 P-loop containing region of AAA domain ATPase_2 PF01637.18 ELR23022.1 - 0.31 10.9 0.0 0.31 10.9 0.0 2.5 3 0 0 3 3 3 0 ATPase domain predominantly from Archaea UvrD-helicase PF00580.21 ELR23022.1 - 0.77 9.2 9.0 0.43 10.1 0.0 2.5 2 0 0 2 2 2 0 UvrD/REP helicase N-terminal domain Helicase_RecD PF05127.14 ELR23022.1 - 0.9 9.4 6.6 13 5.6 0.2 3.0 2 1 0 2 2 2 0 Helicase RSB_motif PF16294.5 ELR23022.1 - 2.7 8.3 23.9 2.5 8.4 9.1 2.9 2 0 0 2 2 2 0 RNSP1-SAP18 binding (RSB) motif Viral_helicase1 PF01443.18 ELR23022.1 - 6.9 6.3 9.7 1.2 8.8 0.0 3.7 4 1 0 4 4 3 0 Viral (Superfamily 1) RNA helicase Sugar_tr PF00083.24 ELR23023.1 - 2.9e-43 148.4 21.1 7e-43 147.1 21.1 1.5 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 ELR23023.1 - 3.4e-31 108.4 47.1 3e-28 98.8 29.6 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF4719 PF15843.5 ELR23023.1 - 0.021 15.0 0.1 0.051 13.7 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4719) BT1 PF03092.16 ELR23023.1 - 0.25 9.5 7.8 0.77 7.9 0.3 2.4 2 1 0 2 2 2 0 BT1 family PBP_like_2 PF12849.7 ELR23024.1 - 5.2e-52 177.3 24.1 1.7e-33 116.6 5.7 2.2 2 0 0 2 2 2 2 PBP superfamily domain Pkinase_Tyr PF07714.17 ELR23024.1 - 8.7e-46 156.3 0.0 1.3e-45 155.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ELR23024.1 - 6.2e-45 153.6 0.0 9e-45 153.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain PBP_like PF12727.7 ELR23024.1 - 1.7e-07 30.6 0.1 0.00011 21.4 0.0 2.8 2 1 0 2 2 2 2 PBP superfamily domain Pkinase_fungal PF17667.1 ELR23024.1 - 2.2e-05 23.5 0.0 3.3e-05 22.8 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase EGF_2 PF07974.13 ELR23024.1 - 0.00055 20.2 13.4 0.0012 19.1 13.4 1.6 1 0 0 1 1 1 1 EGF-like domain EGF_Tenascin PF18720.1 ELR23024.1 - 0.0022 18.0 7.9 0.0022 18.0 7.9 1.9 2 0 0 2 2 1 1 Tenascin EGF domain EGF PF00008.27 ELR23024.1 - 0.031 14.6 8.1 0.061 13.6 8.1 1.5 1 0 0 1 1 1 0 EGF-like domain ABC1 PF03109.16 ELR23024.1 - 0.14 12.4 0.0 0.4 10.9 0.0 1.7 1 0 0 1 1 1 0 ABC1 family BacteriocIIc_cy PF12173.8 ELR23024.1 - 0.2 12.0 4.3 2.7 8.3 1.5 3.2 3 0 0 3 3 2 0 Bacteriocin class IIc cyclic gassericin A-like hEGF PF12661.7 ELR23024.1 - 0.35 11.6 4.9 0.86 10.3 4.9 1.7 1 0 0 1 1 1 0 Human growth factor-like EGF PI3_PI4_kinase PF00454.27 ELR23025.1 - 3.3e-49 168.0 0.0 1.2e-47 162.8 0.0 2.2 1 1 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase PI3Ka PF00613.20 ELR23025.1 - 6.7e-36 123.4 0.6 7.4e-34 116.8 0.6 2.3 1 1 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) PI3K_C2 PF00792.24 ELR23025.1 - 7.7e-17 61.5 0.0 1.6e-16 60.5 0.0 1.4 1 0 0 1 1 1 1 Phosphoinositide 3-kinase C2 PI3K_rbd PF00794.18 ELR23025.1 - 1.1e-05 25.5 0.0 0.32 11.2 0.0 3.5 3 0 0 3 3 3 2 PI3-kinase family, ras-binding domain DUF4135 PF13575.6 ELR23025.1 - 0.015 14.6 0.0 0.033 13.5 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4135) HEAT_2 PF13646.6 ELR23025.1 - 0.029 14.8 0.0 0.08 13.3 0.0 1.8 1 0 0 1 1 1 0 HEAT repeats HEAT_2 PF13646.6 ELR23027.1 - 5.4e-06 26.7 0.2 0.00016 22.0 0.0 4.4 4 2 1 5 5 5 2 HEAT repeats HEAT_EZ PF13513.6 ELR23027.1 - 5e-05 23.7 4.2 0.0042 17.6 0.0 4.7 5 0 0 5 5 5 1 HEAT-like repeat HEAT PF02985.22 ELR23027.1 - 0.001 19.1 10.1 0.87 10.0 0.0 5.7 6 0 0 6 6 6 2 HEAT repeat PHD_2 PF13831.6 ELR23028.1 - 0.00034 20.1 1.8 0.00034 20.1 1.8 2.7 3 0 0 3 3 3 1 PHD-finger PHD PF00628.29 ELR23028.1 - 0.015 15.2 11.6 0.015 15.2 11.6 3.4 3 0 0 3 3 3 0 PHD-finger ERCC4 PF02732.15 ELR23028.1 - 0.02 15.1 0.0 0.039 14.1 0.0 1.4 1 0 0 1 1 1 0 ERCC4 domain Pkinase PF00069.25 ELR23029.1 - 1e-44 152.9 0.0 1.5e-44 152.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR23029.1 - 8.9e-31 107.1 0.0 1e-27 97.1 0.0 2.5 3 0 0 3 3 3 2 Protein tyrosine kinase HEAT_2 PF13646.6 ELR23029.1 - 0.0068 16.8 1.4 0.29 11.5 0.1 3.7 4 0 0 4 4 4 1 HEAT repeats Arm PF00514.23 ELR23029.1 - 0.066 13.3 0.3 1.4 9.0 0.1 2.8 3 0 0 3 3 3 0 Armadillo/beta-catenin-like repeat Atx10homo_assoc PF09759.9 ELR23029.1 - 0.099 12.7 0.0 0.25 11.4 0.0 1.7 1 0 0 1 1 1 0 Spinocerebellar ataxia type 10 protein domain Pox_Ag35 PF03286.14 ELR23029.1 - 0.42 10.4 7.1 0.15 11.8 3.4 2.1 2 0 0 2 2 2 0 Pox virus Ag35 surface protein Spectrin_like PF18373.1 ELR23031.1 - 0.023 14.8 0.1 0.13 12.3 0.0 2.0 1 1 0 2 2 2 0 Spectrin like domain DUF530 PF04409.12 ELR23031.1 - 0.075 11.4 0.0 0.084 11.2 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF530) QRPTase_C PF01729.19 ELR23031.1 - 0.15 11.8 0.0 0.18 11.6 0.0 1.1 1 0 0 1 1 1 0 Quinolinate phosphoribosyl transferase, C-terminal domain ABC2_membrane PF01061.24 ELR23034.1 - 5.1e-41 140.4 27.7 6.5e-41 140.1 27.7 1.1 1 0 0 1 1 1 1 ABC-2 type transporter ABC_tran PF00005.27 ELR23034.1 - 8.7e-28 97.5 0.0 1.4e-27 96.8 0.0 1.4 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 ELR23034.1 - 4.6e-09 36.5 0.3 1.7e-05 24.8 0.1 2.6 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_25 PF13481.6 ELR23034.1 - 0.0001 22.0 0.0 0.00048 19.8 0.0 2.1 3 0 0 3 3 3 1 AAA domain AAA_16 PF13191.6 ELR23034.1 - 0.00041 20.8 0.1 0.00076 19.9 0.1 1.5 1 0 0 1 1 1 1 AAA ATPase domain Rad17 PF03215.15 ELR23034.1 - 0.00047 20.1 0.1 0.0014 18.6 0.0 1.8 2 0 0 2 2 2 1 Rad17 P-loop domain RsgA_GTPase PF03193.16 ELR23034.1 - 0.0048 16.8 0.0 0.0083 16.0 0.0 1.3 1 0 0 1 1 1 1 RsgA GTPase AAA_22 PF13401.6 ELR23034.1 - 0.015 15.6 0.0 0.038 14.3 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA PF00004.29 ELR23034.1 - 0.016 15.6 0.2 0.2 12.1 0.2 2.4 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) RNA_helicase PF00910.22 ELR23034.1 - 0.017 15.5 0.0 0.035 14.5 0.0 1.5 1 0 0 1 1 1 0 RNA helicase AAA_29 PF13555.6 ELR23034.1 - 0.035 13.8 0.1 0.1 12.4 0.1 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain NACHT PF05729.12 ELR23034.1 - 0.043 13.7 0.1 0.091 12.7 0.1 1.5 1 0 0 1 1 1 0 NACHT domain SMC_N PF02463.19 ELR23034.1 - 0.051 13.0 0.0 10 5.4 0.0 2.3 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 ELR23034.1 - 0.062 13.8 0.3 0.15 12.6 0.1 1.7 2 0 0 2 2 1 0 AAA domain AAA_15 PF13175.6 ELR23034.1 - 0.075 12.7 0.0 6.7 6.3 0.0 2.2 2 0 0 2 2 2 0 AAA ATPase domain AAA_33 PF13671.6 ELR23034.1 - 0.15 12.2 0.0 0.34 11.1 0.0 1.7 1 0 0 1 1 1 0 AAA domain NTPase_1 PF03266.15 ELR23034.1 - 0.15 12.0 0.1 0.37 10.7 0.1 1.7 2 0 0 2 2 2 0 NTPase ABC2_membrane_3 PF12698.7 ELR23034.1 - 9.7 5.2 25.5 2.6 7.1 21.7 1.8 1 1 0 1 1 1 0 ABC-2 family transporter protein FA_hydroxylase PF04116.13 ELR23035.1 - 3.6e-24 85.6 12.7 3.6e-24 85.6 12.7 2.0 1 1 1 2 2 2 1 Fatty acid hydroxylase superfamily Ras PF00071.22 ELR23036.1 - 4.9e-44 149.8 2.2 9.8e-42 142.3 0.1 2.1 1 1 1 2 2 2 2 Ras family Roc PF08477.13 ELR23036.1 - 1.4e-13 51.1 0.5 9.2e-11 42.0 0.0 2.3 1 1 1 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase RsgA_GTPase PF03193.16 ELR23036.1 - 6.8e-05 22.8 0.1 0.023 14.6 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase Arf PF00025.21 ELR23036.1 - 0.00013 21.5 0.0 0.00016 21.2 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 ELR23036.1 - 0.0039 16.7 0.3 0.011 15.2 0.1 1.8 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain FeoB_N PF02421.18 ELR23036.1 - 0.072 12.6 0.0 0.52 9.8 0.0 2.1 2 0 0 2 2 2 0 Ferrous iron transport protein B ATP_bind_1 PF03029.17 ELR23036.1 - 0.083 12.7 0.0 0.083 12.7 0.0 2.1 2 1 1 3 3 3 0 Conserved hypothetical ATP binding protein PglD_N PF17836.1 ELR23036.1 - 0.11 13.1 0.4 0.23 12.1 0.1 1.7 1 1 0 1 1 1 0 PglD N-terminal domain NB-ARC PF00931.22 ELR23036.1 - 0.22 10.7 0.0 0.22 10.7 0.0 1.7 2 0 0 2 2 2 0 NB-ARC domain AAA_29 PF13555.6 ELR23036.1 - 0.22 11.3 0.7 8.2 6.2 0.0 2.5 2 0 0 2 2 2 0 P-loop containing region of AAA domain ParA PF10609.9 ELR23036.1 - 0.38 10.1 0.1 0.38 10.1 0.1 1.6 2 0 0 2 2 1 0 NUBPL iron-transfer P-loop NTPase tRNA_U5-meth_tr PF05958.11 ELR23037.1 - 3.4e-26 92.1 0.0 1.3e-25 90.2 0.0 1.8 1 1 0 1 1 1 1 tRNA (Uracil-5-)-methyltransferase Methyltransf_31 PF13847.6 ELR23037.1 - 2.9e-08 33.6 0.0 4.8e-08 32.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain RrnaAD PF00398.20 ELR23037.1 - 2.6e-06 26.7 0.0 4.4e-06 26.0 0.0 1.3 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Methyltransf_25 PF13649.6 ELR23037.1 - 5.2e-06 27.1 0.0 1.8e-05 25.4 0.0 2.0 1 0 0 1 1 1 1 Methyltransferase domain Cons_hypoth95 PF03602.15 ELR23037.1 - 2.3e-05 24.1 0.0 4e-05 23.3 0.0 1.3 1 0 0 1 1 1 1 Conserved hypothetical protein 95 PCMT PF01135.19 ELR23037.1 - 0.00012 22.0 0.0 0.00021 21.1 0.0 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) MTS PF05175.14 ELR23037.1 - 0.0013 18.3 0.0 0.0025 17.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain Met_10 PF02475.16 ELR23037.1 - 0.0014 18.5 0.0 0.003 17.3 0.0 1.6 1 0 0 1 1 1 1 Met-10+ like-protein Methyltransf_23 PF13489.6 ELR23037.1 - 0.002 18.0 0.0 0.0036 17.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_15 PF09445.10 ELR23037.1 - 0.0047 16.5 0.0 0.0083 15.7 0.0 1.4 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase DOT1 PF08123.13 ELR23037.1 - 0.0086 15.6 0.0 0.015 14.8 0.0 1.3 1 0 0 1 1 1 1 Histone methylation protein DOT1 Methyltransf_11 PF08241.12 ELR23037.1 - 0.012 16.2 0.0 0.036 14.7 0.0 1.8 1 0 0 1 1 1 0 Methyltransferase domain N6_Mtase PF02384.16 ELR23037.1 - 0.044 13.0 0.0 0.067 12.5 0.0 1.2 1 0 0 1 1 1 0 N-6 DNA Methylase Methyltransf_32 PF13679.6 ELR23037.1 - 0.087 12.8 0.0 0.16 11.9 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain RasGAP PF00616.19 ELR23038.1 - 7.9e-28 97.6 7.6 1.7e-19 70.4 0.0 3.3 3 1 1 4 4 4 2 GTPase-activator protein for Ras-like GTPase Ala_racemase_N PF01168.20 ELR23039.1 - 0.12 12.0 0.1 0.26 10.9 0.1 1.5 1 0 0 1 1 1 0 Alanine racemase, N-terminal domain TatD_DNase PF01026.21 ELR23040.1 - 4.9e-48 163.7 0.0 6.3e-48 163.4 0.0 1.1 1 0 0 1 1 1 1 TatD related DNase NOA36 PF06524.12 ELR23040.1 - 0.71 9.1 3.1 1.2 8.3 3.1 1.3 1 0 0 1 1 1 0 NOA36 protein DUF4632 PF15451.6 ELR23040.1 - 3 8.0 6.1 7.9 6.6 6.1 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4632) Asparaginase_2 PF01112.18 ELR23041.1 - 2.4e-118 394.6 12.9 2.8e-118 394.4 12.9 1.0 1 0 0 1 1 1 1 Asparaginase Per1 PF04080.13 ELR23042.1 - 2.3e-17 63.6 18.5 1.8e-11 44.3 10.1 2.2 1 1 1 2 2 2 2 Per1-like family Synaptobrevin PF00957.21 ELR23043.1 - 1.2e-15 57.1 2.6 2e-15 56.4 2.6 1.3 1 0 0 1 1 1 1 Synaptobrevin Longin PF13774.6 ELR23043.1 - 4.7e-06 26.5 0.0 8.2e-06 25.8 0.0 1.3 1 0 0 1 1 1 1 Regulated-SNARE-like domain CorA PF01544.18 ELR23043.1 - 0.094 12.0 0.4 0.13 11.6 0.4 1.2 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein DUF760 PF05542.11 ELR23043.1 - 0.13 12.6 0.1 0.51 10.7 0.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF760) Myotub-related PF06602.14 ELR23045.1 - 2.2e-63 214.4 0.1 6.4e-63 212.8 0.1 1.8 1 1 0 1 1 1 1 Myotubularin-like phosphatase domain Pkinase_Tyr PF07714.17 ELR23045.1 - 2.6e-49 167.8 0.0 1.2e-46 159.1 0.0 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase COR PF16095.5 ELR23045.1 - 1.5e-40 139.1 0.0 6.5e-40 137.0 0.0 2.0 1 1 0 1 1 1 1 C-terminal of Roc, COR, domain Pkinase PF00069.25 ELR23045.1 - 2.9e-40 138.3 0.0 7.1e-39 133.8 0.0 2.3 2 0 0 2 2 2 1 Protein kinase domain LRR_8 PF13855.6 ELR23045.1 - 1.1e-35 121.1 40.2 6e-09 35.5 1.9 5.8 5 0 0 5 5 5 5 Leucine rich repeat LRR_4 PF12799.7 ELR23045.1 - 2.7e-30 103.9 37.1 2.7e-06 27.6 3.3 7.7 7 0 0 7 7 7 7 Leucine Rich repeats (2 copies) Roc PF08477.13 ELR23045.1 - 3e-23 82.3 0.0 8.5e-21 74.4 0.0 2.6 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 ELR23045.1 - 6.5e-10 38.8 0.1 1.2e-07 31.5 0.0 2.3 2 0 0 2 2 2 1 Ras family MMR_HSR1 PF01926.23 ELR23045.1 - 0.00016 21.7 0.0 0.00043 20.4 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase Arf PF00025.21 ELR23045.1 - 0.00038 20.0 0.0 0.38 10.2 0.0 2.6 2 0 0 2 2 2 2 ADP-ribosylation factor family LRR_1 PF00560.33 ELR23045.1 - 0.0044 17.4 35.7 6.5 7.7 0.3 10.3 10 1 0 10 10 10 1 Leucine Rich Repeat ABC_tran PF00005.27 ELR23045.1 - 0.024 15.1 0.2 0.16 12.4 0.0 2.6 2 0 0 2 2 1 0 ABC transporter RsgA_GTPase PF03193.16 ELR23045.1 - 0.083 12.8 0.1 0.26 11.2 0.1 1.8 2 0 0 2 2 2 0 RsgA GTPase APH PF01636.23 ELR23045.1 - 0.83 9.5 0.0 0.83 9.5 0.0 3.1 3 0 0 3 3 3 0 Phosphotransferase enzyme family Ras PF00071.22 ELR23046.1 - 1.2e-28 99.8 0.0 6.6e-27 94.1 0.0 2.1 1 1 0 1 1 1 1 Ras family Roc PF08477.13 ELR23046.1 - 2.7e-05 24.4 0.0 0.0004 20.6 0.0 2.5 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 ELR23046.1 - 0.0031 17.6 0.0 0.0052 16.9 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 ELR23046.1 - 0.0035 17.3 0.0 1.4 8.8 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase GTP_EFTU PF00009.27 ELR23046.1 - 0.0049 16.4 0.0 0.031 13.8 0.0 2.3 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Arf PF00025.21 ELR23046.1 - 0.015 14.8 0.0 0.15 11.5 0.0 2.1 2 0 0 2 2 2 0 ADP-ribosylation factor family FeoB_N PF02421.18 ELR23046.1 - 0.16 11.4 0.0 11 5.6 0.0 2.1 2 0 0 2 2 2 0 Ferrous iron transport protein B PH PF00169.29 ELR23047.1 - 3.6e-10 40.3 0.1 9e-10 39.0 0.1 1.7 1 0 0 1 1 1 1 PH domain SH3_2 PF07653.17 ELR23047.1 - 5.2e-10 38.9 0.3 2.8e-09 36.5 0.3 2.1 2 0 0 2 2 2 1 Variant SH3 domain SH3_1 PF00018.28 ELR23047.1 - 1.1e-06 28.1 0.0 2e-05 24.1 0.0 2.4 2 0 0 2 2 2 1 SH3 domain SH3_9 PF14604.6 ELR23047.1 - 0.0025 17.6 0.0 0.006 16.4 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain Erf4 PF10256.9 ELR23048.1 - 5.1e-06 26.6 0.0 7.1e-06 26.1 0.0 1.2 1 0 0 1 1 1 1 Golgin subfamily A member 7/ERF4 family DUF1641 PF07849.11 ELR23050.1 - 0.14 12.1 0.0 0.29 11.0 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1641) Ank_3 PF13606.6 ELR23050.1 - 0.17 12.5 0.4 16 6.5 0.1 2.8 3 0 0 3 3 3 0 Ankyrin repeat Ank PF00023.30 ELR23050.1 - 0.56 10.7 3.6 27 5.4 3.5 2.5 2 1 0 2 2 2 0 Ankyrin repeat GTP-bdg_N PF13167.6 ELR23053.1 - 8.6e-22 77.6 0.0 1.9e-21 76.5 0.0 1.6 1 0 0 1 1 1 1 GTP-binding GTPase N-terminal GTP-bdg_M PF16360.5 ELR23053.1 - 1.1e-18 67.6 7.6 2.5e-18 66.4 7.6 1.7 1 0 0 1 1 1 1 GTP-binding GTPase Middle Region MMR_HSR1 PF01926.23 ELR23053.1 - 1.4e-12 47.7 0.0 4.7e-12 46.0 0.0 1.9 2 0 0 2 2 2 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 ELR23053.1 - 2.2e-05 24.4 0.1 0.13 12.1 0.0 2.4 2 0 0 2 2 2 2 RsgA GTPase MMR_HSR1_Xtn PF16897.5 ELR23053.1 - 0.00082 19.4 0.0 0.0028 17.6 0.0 1.8 1 1 0 1 1 1 1 C-terminal region of MMR_HSR1 domain FeoB_N PF02421.18 ELR23053.1 - 0.0017 17.9 0.4 0.14 11.7 0.1 2.5 2 0 0 2 2 2 1 Ferrous iron transport protein B Dynamin_N PF00350.23 ELR23053.1 - 0.015 15.3 0.1 0.064 13.3 0.0 2.0 1 1 1 2 2 2 0 Dynamin family GTP_EFTU PF00009.27 ELR23053.1 - 0.028 13.9 0.0 6.6 6.2 0.0 2.4 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain TniB PF05621.11 ELR23053.1 - 0.032 13.6 0.0 0.1 12.0 0.0 1.8 2 0 0 2 2 2 0 Bacterial TniB protein ABC_tran PF00005.27 ELR23053.1 - 0.12 12.9 0.1 0.51 10.8 0.1 2.1 1 1 0 1 1 1 0 ABC transporter Ras PF00071.22 ELR23053.1 - 0.15 11.6 0.0 1.2 8.8 0.0 2.2 1 1 0 1 1 1 0 Ras family eIF-3_zeta PF05091.12 ELR23054.1 - 1.8e-174 581.6 0.2 3e-174 580.8 0.2 1.3 1 1 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) NARG2_C PF10505.9 ELR23054.1 - 0.014 14.9 0.0 0.029 13.9 0.0 1.6 1 1 0 1 1 1 0 NMDA receptor-regulated gene protein 2 C-terminus EP400_N PF15790.5 ELR23055.1 - 0.28 10.0 4.2 0.36 9.6 4.2 1.1 1 0 0 1 1 1 0 E1A-binding protein p400, N-terminal La PF05383.17 ELR23056.1 - 2.5e-22 78.7 0.2 4.5e-22 77.9 0.2 1.4 1 0 0 1 1 1 1 La domain FAD_binding_3 PF01494.19 ELR23057.1 - 1.1e-25 90.6 0.6 9e-25 87.7 0.6 1.9 1 1 0 1 1 1 1 FAD binding domain DAO PF01266.24 ELR23057.1 - 3.5e-06 26.8 2.0 3.5e-06 26.8 2.0 2.0 2 1 0 3 3 3 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 ELR23057.1 - 8e-06 25.3 0.8 0.0016 17.7 0.2 2.2 1 1 1 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 ELR23057.1 - 4.2e-05 23.7 0.4 0.0001 22.4 0.4 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 ELR23057.1 - 0.00044 19.5 1.0 0.00075 18.7 1.0 1.4 1 0 0 1 1 1 1 FAD binding domain GIDA PF01134.22 ELR23057.1 - 0.035 13.2 0.7 0.08 12.0 0.7 1.6 1 0 0 1 1 1 0 Glucose inhibited division protein A Pyr_redox PF00070.27 ELR23057.1 - 0.047 14.3 0.1 0.17 12.4 0.0 1.9 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 ELR23057.1 - 0.06 12.4 0.2 0.19 10.7 0.1 1.7 2 0 0 2 2 2 0 Lycopene cyclase protein GTP_EFTU_D3 PF03143.17 ELR23058.1 - 0.015 15.6 0.0 0.031 14.6 0.0 1.5 1 0 0 1 1 1 0 Elongation factor Tu C-terminal domain Ank PF00023.30 ELR23058.1 - 0.043 14.3 0.5 0.83 10.2 0.6 2.3 2 0 0 2 2 2 0 Ankyrin repeat Ank_3 PF13606.6 ELR23058.1 - 0.081 13.5 0.1 2.2 9.1 0.1 2.6 2 0 0 2 2 2 0 Ankyrin repeat Ank_2 PF12796.7 ELR23058.1 - 0.13 12.8 0.0 0.26 11.9 0.0 1.4 1 0 0 1 1 1 0 Ankyrin repeats (3 copies) UQ_con PF00179.26 ELR23059.1 - 3.2e-13 49.5 0.0 5.1e-13 48.9 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme ubiquitin PF00240.23 ELR23059.1 - 1.9e-12 46.7 0.0 9.3e-12 44.5 0.0 2.0 1 1 1 2 2 2 1 Ubiquitin family GTP_EFTU PF00009.27 ELR23059.1 - 9.4e-10 38.4 0.0 1.4e-09 37.8 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain Rad60-SLD PF11976.8 ELR23059.1 - 0.00047 19.9 0.0 0.0019 18.0 0.0 1.9 2 0 0 2 2 2 1 Ubiquitin-2 like Rad60 SUMO-like Rad60-SLD_2 PF13881.6 ELR23059.1 - 0.0031 17.6 0.0 0.009 16.1 0.0 1.7 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.9 ELR23059.1 - 0.06 13.9 0.0 0.18 12.4 0.0 1.8 1 0 0 1 1 1 0 DUF2407 ubiquitin-like domain Aminotran_1_2 PF00155.21 ELR23060.1 - 9.9e-69 232.2 0.0 1.3e-68 231.9 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.19 ELR23060.1 - 1.2e-05 24.4 0.0 2.2e-05 23.6 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class-V Cys_Met_Meta_PP PF01053.20 ELR23060.1 - 0.0002 20.0 0.0 0.00031 19.4 0.0 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme SHMT PF00464.19 ELR23060.1 - 0.00092 17.9 0.0 0.0067 15.1 0.0 2.0 2 0 0 2 2 2 1 Serine hydroxymethyltransferase DegT_DnrJ_EryC1 PF01041.17 ELR23060.1 - 0.028 13.7 0.1 0.2 10.9 0.1 2.0 1 1 0 1 1 1 0 DegT/DnrJ/EryC1/StrS aminotransferase family Beta_elim_lyase PF01212.21 ELR23060.1 - 0.087 12.1 0.0 0.11 11.7 0.0 1.3 1 0 0 1 1 1 0 Beta-eliminating lyase PAS_9 PF13426.7 ELR23061.1 - 6.8e-07 29.5 0.0 1.3e-06 28.5 0.0 1.4 1 0 0 1 1 1 1 PAS domain PAS_3 PF08447.12 ELR23061.1 - 3e-06 27.4 0.0 4.7e-06 26.8 0.0 1.3 1 0 0 1 1 1 1 PAS fold PAS_4 PF08448.10 ELR23061.1 - 0.0018 18.5 0.0 0.0039 17.4 0.0 1.5 1 0 0 1 1 1 1 PAS fold PAS_8 PF13188.7 ELR23061.1 - 0.0032 17.4 0.0 0.0074 16.3 0.0 1.6 1 0 0 1 1 1 1 PAS domain PAS PF00989.25 ELR23061.1 - 0.005 16.8 0.0 0.0095 15.9 0.0 1.4 1 0 0 1 1 1 1 PAS fold DUF2465 PF10239.9 ELR23062.1 - 7.5e-20 71.4 0.0 7.5e-20 71.4 0.0 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF2465) F-box-like PF12937.7 ELR23063.1 - 6.2e-13 48.4 1.7 1.7e-12 47.1 0.2 2.6 3 0 0 3 3 3 1 F-box-like F-box PF00646.33 ELR23063.1 - 1.3e-05 24.9 0.0 5.1e-05 23.0 0.0 2.1 1 0 0 1 1 1 1 F-box domain F-box_4 PF15966.5 ELR23063.1 - 9e-05 22.3 0.1 0.00019 21.3 0.1 1.5 1 0 0 1 1 1 1 F-box Elongin_A PF06881.11 ELR23063.1 - 0.00056 20.4 0.2 0.0011 19.5 0.2 1.5 1 0 0 1 1 1 1 RNA polymerase II transcription factor SIII (Elongin) subunit A NUDIX PF00293.28 ELR23064.1 - 1.1e-16 61.0 0.1 1.9e-16 60.3 0.1 1.3 1 0 0 1 1 1 1 NUDIX domain NUDIX_4 PF14815.6 ELR23064.1 - 0.0021 18.0 0.0 0.0037 17.2 0.0 1.4 1 1 0 1 1 1 1 NUDIX domain DUF5423 PF17461.2 ELR23064.1 - 0.21 10.4 2.2 0.28 10.0 2.2 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5423) PLDc_2 PF13091.6 ELR23065.1 - 1.3e-15 57.4 0.0 1.5e-06 28.1 0.0 2.2 2 0 0 2 2 2 2 PLD-like domain PLDc PF00614.22 ELR23065.1 - 0.032 14.4 1.5 0.44 10.8 0.2 2.5 2 0 0 2 2 2 0 Phospholipase D Active site motif Ribosomal_L22e PF01776.17 ELR23066.1 - 1.7e-47 160.3 4.4 2.5e-47 159.8 4.4 1.2 1 0 0 1 1 1 1 Ribosomal L22e protein family Dapper PF15268.6 ELR23066.1 - 0.24 10.2 11.7 0.26 10.1 11.7 1.0 1 0 0 1 1 1 0 Dapper Aminotran_1_2 PF00155.21 ELR23067.1 - 4.2e-39 134.7 0.0 3e-24 85.9 0.0 2.0 2 0 0 2 2 2 2 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.20 ELR23067.1 - 0.037 12.5 0.0 0.075 11.6 0.0 1.4 1 0 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme DUF3989 PF13150.6 ELR23067.1 - 0.17 11.6 0.0 0.37 10.6 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3989) BNR_3 PF13859.6 ELR23068.1 - 0.36 10.1 3.7 0.69 9.2 3.7 1.4 1 0 0 1 1 1 0 BNR repeat-like domain Vma12 PF11712.8 ELR23068.1 - 1.1 9.3 0.0 1.1 9.3 0.0 3.5 3 1 0 3 3 3 0 Endoplasmic reticulum-based factor for assembly of V-ATPase Glyco_transf_8 PF01501.20 ELR23069.1 - 0.00021 21.0 0.1 0.00071 19.2 0.1 1.8 1 1 0 1 1 1 1 Glycosyl transferase family 8 Mannosyl_trans3 PF11051.8 ELR23069.1 - 0.0017 17.8 0.0 0.0025 17.2 0.0 1.2 1 0 0 1 1 1 1 Mannosyltransferase putative Nucleotid_trans PF03407.16 ELR23069.1 - 0.002 18.1 0.1 0.003 17.5 0.1 1.3 1 0 0 1 1 1 1 Nucleotide-diphospho-sugar transferase PUB PF09409.10 ELR23070.1 - 3.5e-14 52.5 0.0 6e-14 51.7 0.0 1.3 1 0 0 1 1 1 1 PUB domain HMG_box_2 PF09011.10 ELR23071.1 - 0.0089 16.6 0.1 0.014 15.9 0.1 1.3 1 0 0 1 1 1 1 HMG-box domain Forkhead PF00250.18 ELR23072.1 - 0.0002 21.6 0.0 0.024 14.9 0.0 3.1 3 0 0 3 3 3 2 Forkhead domain TLD PF07534.16 ELR23073.1 - 4.1e-33 114.5 0.1 7.1e-33 113.8 0.1 1.4 1 0 0 1 1 1 1 TLD MDM1 PF15501.6 ELR23073.1 - 0.011 14.9 2.2 0.02 14.1 2.2 1.3 1 0 0 1 1 1 0 Nuclear protein MDM1 YcgL PF05166.13 ELR23073.1 - 0.035 14.5 0.0 0.082 13.3 0.0 1.6 1 0 0 1 1 1 0 YcgL domain PIP5K PF01504.18 ELR23073.1 - 0.15 11.3 1.5 0.26 10.5 1.5 1.3 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase Presenilin PF01080.17 ELR23073.1 - 0.31 9.8 1.1 0.5 9.1 1.1 1.2 1 0 0 1 1 1 0 Presenilin PTPRCAP PF15713.5 ELR23073.1 - 0.41 10.9 11.0 0.49 10.7 7.9 2.1 2 0 0 2 2 2 0 Protein tyrosine phosphatase receptor type C-associated CobT PF06213.12 ELR23073.1 - 1.1 8.6 11.0 2.3 7.5 11.0 1.4 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT CDC45 PF02724.14 ELR23073.1 - 2.2 6.5 9.4 3.6 5.8 9.4 1.2 1 0 0 1 1 1 0 CDC45-like protein FAM176 PF14851.6 ELR23073.1 - 3 7.5 8.0 7 6.3 4.6 2.2 2 0 0 2 2 2 0 FAM176 family HSP90 PF00183.18 ELR23073.1 - 4.5 6.1 9.9 8.1 5.2 9.9 1.3 1 0 0 1 1 1 0 Hsp90 protein Cnd2 PF05786.14 ELR23073.1 - 8.2 4.9 12.3 13 4.3 12.3 1.2 1 0 0 1 1 1 0 Condensin complex subunit 2 PH PF00169.29 ELR23075.1 - 8.4e-15 55.2 0.0 2e-14 54.0 0.0 1.7 1 0 0 1 1 1 1 PH domain IPK PF03770.16 ELR23075.1 - 2.1e-10 40.8 0.1 9.2e-08 32.2 0.0 3.1 2 1 0 2 2 2 1 Inositol polyphosphate kinase PH_11 PF15413.6 ELR23075.1 - 2.5 8.6 6.8 1.1 9.7 2.0 2.8 2 1 0 2 2 2 0 Pleckstrin homology domain MetOD1 PF18546.1 ELR23076.1 - 0.046 13.7 0.1 0.079 12.9 0.1 1.3 1 0 0 1 1 1 0 Metanogen output domain 1 Sod_Cu PF00080.20 ELR23077.1 - 2.7e-09 37.3 0.0 3.7e-09 36.9 0.0 1.2 1 0 0 1 1 1 1 Copper/zinc superoxide dismutase (SODC) HMA PF00403.26 ELR23077.1 - 3.4e-08 33.8 0.1 5.8e-08 33.1 0.1 1.4 1 0 0 1 1 1 1 Heavy-metal-associated domain SIR2 PF02146.17 ELR23078.1 - 2.4e-37 128.6 0.0 3.2e-37 128.2 0.0 1.2 1 0 0 1 1 1 1 Sir2 family zf-ZPR1 PF03367.13 ELR23078.1 - 1.6e-17 63.8 0.0 2.7e-17 63.1 0.0 1.3 1 0 0 1 1 1 1 ZPR1 zinc-finger domain TPP_enzyme_M PF00205.22 ELR23078.1 - 0.0011 18.8 0.0 0.52 10.1 0.0 2.4 2 0 0 2 2 2 2 Thiamine pyrophosphate enzyme, central domain APS_kinase PF01583.20 ELR23079.1 - 3e-64 215.7 0.0 3.8e-64 215.4 0.0 1.1 1 0 0 1 1 1 1 Adenylylsulphate kinase AAA_33 PF13671.6 ELR23079.1 - 1.3e-05 25.4 0.0 2.2e-05 24.6 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 ELR23079.1 - 0.00092 19.8 0.0 0.0014 19.2 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 ELR23079.1 - 0.0018 18.7 0.2 0.0026 18.2 0.2 1.3 1 1 0 1 1 1 1 AAA ATPase domain CPT PF07931.12 ELR23079.1 - 0.0035 17.2 1.0 0.025 14.4 1.0 2.0 1 1 0 1 1 1 1 Chloramphenicol phosphotransferase-like protein AAA_29 PF13555.6 ELR23079.1 - 0.011 15.5 0.1 0.018 14.8 0.1 1.3 1 0 0 1 1 1 0 P-loop containing region of AAA domain KTI12 PF08433.10 ELR23079.1 - 0.05 13.1 0.0 0.06 12.8 0.0 1.2 1 0 0 1 1 1 0 Chromatin associated protein KTI12 DUF463 PF04317.12 ELR23079.1 - 0.091 11.7 0.1 0.13 11.2 0.1 1.1 1 0 0 1 1 1 0 YcjX-like family, DUF463 RNA_helicase PF00910.22 ELR23079.1 - 0.18 12.2 0.0 0.26 11.7 0.0 1.4 1 0 0 1 1 1 0 RNA helicase Ank_2 PF12796.7 ELR23080.1 - 3.5e-38 130.1 6.6 1e-18 67.7 0.2 4.4 2 1 2 4 4 4 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ELR23080.1 - 3.2e-33 113.7 3.1 2.6e-10 40.6 0.1 5.5 3 2 3 6 6 6 5 Ankyrin repeats (many copies) Ank PF00023.30 ELR23080.1 - 5e-29 99.4 3.8 1.2e-06 28.7 0.0 6.8 6 0 0 6 6 6 6 Ankyrin repeat Ank_3 PF13606.6 ELR23080.1 - 3.8e-26 88.3 1.7 0.0011 19.2 0.0 7.6 7 0 0 7 7 7 6 Ankyrin repeat Ank_5 PF13857.6 ELR23080.1 - 2.2e-24 85.2 5.8 1.7e-08 34.6 0.0 6.6 2 1 5 7 7 7 5 Ankyrin repeats (many copies) C2 PF00168.30 ELR23080.1 - 4.7e-13 49.3 0.0 7.3e-09 35.9 0.0 3.0 2 1 0 2 2 2 2 C2 domain Calpain_III PF01067.22 ELR23080.1 - 1.3e-12 48.1 1.0 6.9e-12 45.8 0.0 2.7 3 0 0 3 3 3 1 Calpain large subunit, domain III Connexin PF00029.19 ELR23080.1 - 4.5 7.0 9.4 0.16 11.7 0.1 2.7 3 0 0 3 3 3 0 Connexin Actin PF00022.19 ELR23081.1 - 1.3e-48 165.6 0.1 4.2e-30 104.7 0.2 4.5 1 1 1 2 2 2 2 Actin 2OG-FeII_Oxy_3 PF13640.6 ELR23082.1 - 4.4e-12 46.7 0.0 1.3e-11 45.2 0.0 1.7 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily PhyH PF05721.13 ELR23082.1 - 0.0026 18.0 0.0 0.0059 16.9 0.0 1.5 1 1 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) 2OG-FeII_Oxy_5 PF13759.6 ELR23082.1 - 0.018 15.5 0.0 0.044 14.2 0.0 1.6 1 0 0 1 1 1 0 Putative 2OG-Fe(II) oxygenase YEATS PF03366.16 ELR23083.1 - 6e-26 90.2 0.6 1.5e-25 89.0 0.6 1.7 1 0 0 1 1 1 1 YEATS family BUD22 PF09073.10 ELR23083.1 - 0.0026 17.2 11.4 0.0026 17.2 11.4 5.4 3 2 1 4 4 4 1 BUD22 EF-hand_1 PF00036.32 ELR23084.1 - 7.3e-16 56.5 0.0 0.00096 18.5 0.0 3.9 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.6 ELR23084.1 - 1.4e-15 55.8 0.1 0.00033 20.4 0.0 4.2 5 0 0 5 5 5 3 EF-hand domain EF-hand_5 PF13202.6 ELR23084.1 - 1.9e-13 49.2 0.2 6.5e-05 22.2 0.0 3.3 3 0 0 3 3 3 3 EF hand EF-hand_7 PF13499.6 ELR23084.1 - 2.5e-11 43.8 0.2 0.017 15.5 0.0 3.4 4 0 0 4 4 4 3 EF-hand domain pair EF-hand_8 PF13833.6 ELR23084.1 - 5.2e-06 26.2 0.0 0.47 10.3 0.0 3.4 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_4 PF12763.7 ELR23084.1 - 0.057 13.4 0.1 0.47 10.4 0.0 2.0 1 1 1 2 2 2 0 Cytoskeletal-regulatory complex EF hand TTL PF03133.15 ELR23085.1 - 2.2e-56 191.2 0.0 5.1e-55 186.7 0.0 2.3 2 1 0 2 2 2 1 Tubulin-tyrosine ligase family ATPgrasp_YheCD PF14398.6 ELR23085.1 - 1.2e-06 28.0 0.0 1.6e-05 24.3 0.0 2.3 2 0 0 2 2 2 1 YheC/D like ATP-grasp ATPgrasp_ST PF14397.6 ELR23085.1 - 0.00033 20.0 0.0 0.00074 18.9 0.0 1.5 1 0 0 1 1 1 1 Sugar-transfer associated ATP-grasp Dala_Dala_lig_C PF07478.13 ELR23085.1 - 0.017 14.7 0.0 0.23 11.0 0.0 2.1 2 0 0 2 2 2 0 D-ala D-ala ligase C-terminus WLM PF08325.10 ELR23086.1 - 0.098 12.7 3.4 0.13 12.4 3.4 1.1 1 0 0 1 1 1 0 WLM domain Actin PF00022.19 ELR23087.1 - 1.3e-154 514.7 0.0 4.2e-154 513.1 0.0 1.6 1 1 0 1 1 1 1 Actin Brix PF04427.18 ELR23088.1 - 3.2e-31 108.9 0.3 4.9e-31 108.3 0.3 1.3 1 0 0 1 1 1 1 Brix domain POX PF07526.11 ELR23088.1 - 0.11 13.0 0.3 0.24 12.0 0.3 1.5 1 0 0 1 1 1 0 Associated with HOX adh_short PF00106.25 ELR23089.1 - 1.2e-60 204.3 0.9 1.4e-60 204.1 0.9 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ELR23089.1 - 5.9e-45 153.6 1.2 7.3e-45 153.3 1.2 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ELR23089.1 - 1.3e-13 51.3 0.5 1.9e-13 50.7 0.5 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 ELR23089.1 - 1.1e-05 25.1 1.9 0.003 17.1 1.9 2.8 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 ELR23089.1 - 2.4e-05 24.3 4.0 0.00025 21.0 4.0 2.1 1 1 0 1 1 1 1 NAD(P)H-binding F420_oxidored PF03807.17 ELR23089.1 - 6.7e-05 23.4 1.5 0.00012 22.5 0.8 1.8 2 0 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent THF_DHG_CYH_C PF02882.19 ELR23089.1 - 0.00031 20.1 0.4 0.00063 19.1 0.4 1.6 1 1 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain 3HCDH_N PF02737.18 ELR23089.1 - 0.004 17.1 0.8 0.0063 16.4 0.8 1.3 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain ApbA PF02558.16 ELR23089.1 - 0.0082 15.8 0.1 0.016 14.9 0.0 1.5 2 0 0 2 2 2 1 Ketopantoate reductase PanE/ApbA 2-Hacid_dh_C PF02826.19 ELR23089.1 - 0.0086 15.4 0.4 0.013 14.9 0.4 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Polysacc_synt_2 PF02719.15 ELR23089.1 - 0.018 14.2 0.1 0.027 13.6 0.1 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein Adenine_deam_C PF13382.6 ELR23089.1 - 0.064 12.6 0.8 0.098 12.0 0.8 1.2 1 0 0 1 1 1 0 Adenine deaminase C-terminal domain Nitro_FeMo-Co PF02579.17 ELR23089.1 - 0.12 12.7 0.4 5.1 7.5 0.2 2.4 2 0 0 2 2 2 0 Dinitrogenase iron-molybdenum cofactor zf-CCCH PF00642.24 ELR23090.1 - 2.4e-21 75.1 9.9 7.9e-07 28.8 0.2 3.3 3 0 0 3 3 3 3 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Torus PF16131.5 ELR23090.1 - 6.5e-16 59.0 10.5 1.8e-05 25.4 0.1 3.4 1 1 2 3 3 3 3 Torus domain zf_CCCH_4 PF18345.1 ELR23090.1 - 2.8e-15 55.8 22.0 1.9e-05 24.6 2.3 3.3 3 0 0 3 3 3 3 Zinc finger domain zf-CCCH_4 PF18044.1 ELR23090.1 - 1.8e-12 46.7 14.5 7.6e-05 22.4 1.6 3.3 3 0 0 3 3 3 3 CCCH-type zinc finger zf-CCCH_2 PF14608.6 ELR23090.1 - 1.6e-05 25.2 16.8 0.0053 17.2 1.1 3.3 3 0 0 3 3 3 2 RNA-binding, Nab2-type zinc finger bZIP_1 PF00170.21 ELR23090.1 - 0.00026 21.0 0.3 0.00044 20.3 0.3 1.4 1 0 0 1 1 1 1 bZIP transcription factor DivIC PF04977.15 ELR23090.1 - 0.00065 19.4 4.2 0.0014 18.4 4.2 1.5 1 0 0 1 1 1 1 Septum formation initiator HALZ PF02183.18 ELR23090.1 - 0.0029 17.8 1.3 0.0047 17.1 1.3 1.3 1 0 0 1 1 1 1 Homeobox associated leucine zipper TSC22 PF01166.18 ELR23090.1 - 0.0059 16.9 0.6 0.011 16.1 0.6 1.3 1 0 0 1 1 1 1 TSC-22/dip/bun family CtIP_N PF10482.9 ELR23090.1 - 0.01 15.9 0.6 0.018 15.1 0.6 1.3 1 0 0 1 1 1 0 Tumour-suppressor protein CtIP N-terminal domain zf-CCCH_3 PF15663.5 ELR23090.1 - 0.013 15.7 9.8 0.46 10.7 2.6 3.0 2 1 0 2 2 2 0 Zinc-finger containing family ZapB PF06005.12 ELR23090.1 - 0.025 15.0 4.6 0.042 14.3 4.6 1.3 1 0 0 1 1 1 0 Cell division protein ZapB DUF4140 PF13600.6 ELR23090.1 - 0.045 14.2 0.2 0.072 13.5 0.2 1.3 1 0 0 1 1 1 0 N-terminal domain of unknown function (DUF4140) MAD PF05557.13 ELR23090.1 - 0.077 11.4 0.8 0.1 11.0 0.8 1.1 1 0 0 1 1 1 0 Mitotic checkpoint protein DUF2381 PF09544.10 ELR23090.1 - 0.091 12.3 0.3 0.13 11.8 0.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2381) NRBF2 PF08961.10 ELR23090.1 - 0.32 10.6 3.7 0.11 12.1 0.8 1.6 2 0 0 2 2 2 0 Nuclear receptor-binding factor 2, autophagy regulator bZIP_2 PF07716.15 ELR23090.1 - 1.6 8.9 11.6 0.14 12.2 6.4 2.0 2 1 0 2 2 1 0 Basic region leucine zipper SH3_1 PF00018.28 ELR23091.1 - 0.0066 16.0 0.0 0.3 10.7 0.0 2.4 2 0 0 2 2 2 1 SH3 domain SH3_9 PF14604.6 ELR23091.1 - 0.072 13.0 0.0 0.5 10.3 0.0 2.1 1 1 0 1 1 1 0 Variant SH3 domain Methyltransf_16 PF10294.9 ELR23092.1 - 5.8e-18 65.2 0.0 9e-18 64.6 0.0 1.2 1 0 0 1 1 1 1 Lysine methyltransferase Methyltransf_31 PF13847.6 ELR23092.1 - 7.5e-10 38.8 0.0 1.3e-09 38.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 ELR23092.1 - 1.1e-08 35.1 0.0 1.7e-08 34.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ELR23092.1 - 1.3e-07 32.2 0.0 2.7e-07 31.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ELR23092.1 - 3.9e-07 30.6 0.0 2.7e-06 27.9 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 ELR23092.1 - 9.2e-06 26.3 0.0 1.6e-05 25.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 ELR23092.1 - 0.00014 21.5 0.0 0.00021 20.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain TehB PF03848.14 ELR23092.1 - 0.0022 17.4 0.0 0.0032 16.9 0.0 1.3 1 0 0 1 1 1 1 Tellurite resistance protein TehB HlyD_D23 PF16576.5 ELR23092.1 - 0.14 11.3 0.0 0.18 11.0 0.0 1.2 1 0 0 1 1 1 0 Barrel-sandwich domain of CusB or HlyD membrane-fusion Rap_GAP PF02145.15 ELR23094.1 - 2.3e-61 206.6 0.0 5e-61 205.5 0.0 1.6 2 0 0 2 2 2 1 Rap/ran-GAP DUF3330 PF11809.8 ELR23095.1 - 0.39 10.8 2.1 1 9.4 0.0 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF3330) DnaJ PF00226.31 ELR23096.1 - 3.4e-11 43.1 0.1 5.3e-11 42.5 0.1 1.3 1 0 0 1 1 1 1 DnaJ domain Laminin_G_3 PF13385.6 ELR23097.1 - 3.1e-05 24.2 0.0 7.8e-05 22.9 0.0 1.5 1 1 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily FMN_red PF03358.15 ELR23101.1 - 2e-30 105.6 0.0 2.8e-30 105.1 0.0 1.2 1 0 0 1 1 1 1 NADPH-dependent FMN reductase Flavodoxin_2 PF02525.17 ELR23101.1 - 4.7e-10 39.5 0.0 6.1e-10 39.1 0.0 1.2 1 0 0 1 1 1 1 Flavodoxin-like fold Sortilin-Vps10 PF15902.5 ELR23102.1 - 4.8e-09 35.5 4.5 0.00058 18.8 0.0 2.8 1 1 2 3 3 3 3 Sortilin, neurotensin receptor 3, BNR PF02012.20 ELR23102.1 - 2.3e-05 23.7 8.2 1 9.6 0.0 5.0 4 0 0 4 4 4 3 BNR/Asp-box repeat PSII_BNR PF14870.6 ELR23102.1 - 0.0049 16.2 1.4 0.0049 16.2 1.4 2.6 1 1 2 3 3 3 2 Photosynthesis system II assembly factor YCF48 E6 PF00518.17 ELR23103.1 - 0.032 14.7 0.3 0.1 13.1 0.3 1.8 1 0 0 1 1 1 0 Early Protein (E6) PAS_4 PF08448.10 ELR23105.1 - 1.2e-07 32.0 0.1 2e-07 31.2 0.1 1.4 1 0 0 1 1 1 1 PAS fold Response_reg PF00072.24 ELR23105.1 - 6.3e-07 29.5 0.0 3.6e-06 27.1 0.0 2.1 2 0 0 2 2 2 1 Response regulator receiver domain PAS PF00989.25 ELR23105.1 - 8e-07 29.1 0.0 1.3e-06 28.3 0.0 1.4 1 0 0 1 1 1 1 PAS fold PAS_9 PF13426.7 ELR23105.1 - 8.3e-05 22.8 0.0 0.00013 22.2 0.0 1.4 1 0 0 1 1 1 1 PAS domain PAS_8 PF13188.7 ELR23105.1 - 0.009 16.0 0.3 0.015 15.3 0.3 1.3 1 0 0 1 1 1 1 PAS domain IIGP PF05049.13 ELR23107.1 - 2.2e-28 99.4 0.0 2.6e-28 99.2 0.0 1.0 1 0 0 1 1 1 1 Interferon-inducible GTPase (IIGP) CCDC50_N PF15295.6 ELR23108.1 - 0.00074 19.7 10.7 0.018 15.2 10.7 2.2 1 1 1 2 2 2 2 Coiled-coil domain-containing protein 50 N-terminus RecX PF02631.16 ELR23108.1 - 0.032 14.7 0.4 0.032 14.7 0.4 2.1 1 1 1 2 2 2 0 RecX family CPSase_L_D3 PF02787.19 ELR23108.1 - 0.2 12.0 1.4 0.37 11.1 0.2 1.9 1 1 1 2 2 2 0 Carbamoyl-phosphate synthetase large chain, oligomerisation domain CHASE6_C PF17150.4 ELR23110.1 - 0.14 12.8 0.4 0.44 11.2 0.4 1.8 1 0 0 1 1 1 0 C-terminal domain of two-partite extracellular sensor domain CDC13_N PF16853.5 ELR23110.1 - 0.22 11.0 0.5 0.34 10.4 0.5 1.2 1 0 0 1 1 1 0 Cell division control protein 13 N-terminus TPR_2 PF07719.17 ELR23111.1 - 0.00031 20.6 6.5 3.9 7.8 0.1 4.7 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_12 PF13424.6 ELR23111.1 - 0.0048 17.2 9.5 0.17 12.2 0.3 4.7 3 2 2 5 5 5 2 Tetratricopeptide repeat TPR_11 PF13414.6 ELR23111.1 - 0.0059 16.3 0.1 0.61 9.8 0.0 2.8 2 0 0 2 2 2 1 TPR repeat TPR_1 PF00515.28 ELR23111.1 - 0.0061 16.3 2.2 2.6 8.0 0.0 3.7 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_10 PF13374.6 ELR23111.1 - 0.018 14.9 5.8 11 6.0 0.0 5.1 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_14 PF13428.6 ELR23111.1 - 0.029 15.2 4.6 1.8 9.6 0.0 5.0 5 0 0 5 5 5 0 Tetratricopeptide repeat Peptidase_M78 PF06114.13 ELR23111.1 - 0.037 14.0 1.7 0.21 11.5 1.5 2.3 2 0 0 2 2 2 0 IrrE N-terminal-like domain TPR_8 PF13181.6 ELR23111.1 - 0.047 13.9 1.3 9.7 6.7 0.0 4.3 4 0 0 4 4 4 0 Tetratricopeptide repeat ANAPC3 PF12895.7 ELR23111.1 - 0.056 13.7 3.1 15 5.9 0.1 3.6 3 0 0 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 Utp14 PF04615.13 ELR23111.1 - 0.12 11.0 12.3 0.16 10.5 12.3 1.1 1 0 0 1 1 1 0 Utp14 protein BSP_II PF05432.11 ELR23111.1 - 0.14 11.8 18.1 0.29 10.8 18.1 1.4 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) CDC45 PF02724.14 ELR23111.1 - 2.1 6.5 9.3 3.1 6.0 9.3 1.2 1 0 0 1 1 1 0 CDC45-like protein GD_AH_C PF04295.13 ELR23113.1 - 1.9e-12 46.7 0.0 1.3e-11 43.9 0.0 1.9 2 0 0 2 2 2 1 D-galactarate dehydratase / Altronate hydrolase, C terminus FAD_binding_4 PF01565.23 ELR23114.1 - 9e-18 64.4 0.0 1.1e-17 64.0 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain PHD PF00628.29 ELR23115.1 - 8.9e-08 31.9 10.9 8.9e-08 31.9 10.9 1.7 2 0 0 2 2 2 1 PHD-finger zf-UDP PF14569.6 ELR23115.1 - 0.00091 19.3 1.3 0.91 9.7 1.4 2.2 2 0 0 2 2 2 2 Zinc-binding RING-finger PHD_2 PF13831.6 ELR23115.1 - 0.002 17.6 5.2 0.002 17.6 5.2 2.0 2 0 0 2 2 2 1 PHD-finger zf-RING_2 PF13639.6 ELR23115.1 - 0.0044 17.3 18.3 0.0059 16.9 9.9 2.4 2 0 0 2 2 2 1 Ring finger domain zf-RING_11 PF17123.5 ELR23115.1 - 0.011 15.4 6.1 0.22 11.3 3.2 2.8 2 0 0 2 2 2 0 RING-like zinc finger DZR PF12773.7 ELR23115.1 - 0.33 11.0 9.5 5.7 7.0 5.2 3.2 2 1 0 2 2 2 0 Double zinc ribbon zf-RING_9 PF13901.6 ELR23115.1 - 0.58 10.1 8.6 0.15 12.1 2.5 2.1 1 1 0 2 2 2 0 Putative zinc-RING and/or ribbon zf-C3HC4_4 PF15227.6 ELR23115.1 - 2.4 8.4 10.0 5.3 7.3 3.6 2.7 2 1 0 2 2 2 0 zinc finger of C3HC4-type, RING H_kinase_N PF12282.8 ELR23116.1 - 0.17 11.8 0.0 0.3 11.0 0.0 1.3 1 0 0 1 1 1 0 Signal transduction histidine kinase F-box-like PF12937.7 ELR23117.1 - 0.011 15.6 0.0 0.027 14.4 0.0 1.7 1 1 0 1 1 1 0 F-box-like efThoc1 PF11957.8 ELR23123.1 - 1.7e-34 119.4 1.8 1.4e-27 96.5 0.0 2.3 1 1 1 2 2 2 2 THO complex subunit 1 transcription elongation factor Ebp2 PF05890.12 ELR23123.1 - 0.0035 16.9 4.4 0.0083 15.7 4.4 1.7 1 0 0 1 1 1 1 Eukaryotic rRNA processing protein EBP2 BCL_N PF04714.13 ELR23124.1 - 1.4e-06 28.2 3.4 1.4e-06 28.2 3.4 2.8 3 0 0 3 3 3 1 BCL7, N-terminal conserver region eIF3_p135 PF12807.7 ELR23126.1 - 2.3e-08 34.3 2.2 2.3e-08 34.3 2.2 1.9 2 0 0 2 2 2 1 Translation initiation factor eIF3 subunit 135 PA28_alpha PF02251.18 ELR23126.1 - 0.046 13.8 0.0 0.14 12.2 0.0 1.8 1 0 0 1 1 1 0 Proteasome activator pa28 alpha subunit DUF1664 PF07889.12 ELR23126.1 - 0.23 11.5 7.4 1.5 8.8 1.6 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) EF-G-binding_N PF07299.11 ELR23126.1 - 1.2 9.7 5.7 8.9 6.9 0.3 3.0 2 1 0 2 2 2 0 Elongation factor G-binding protein, N-terminal GCIP PF13324.6 ELR23126.1 - 1.8 8.1 12.6 1.6 8.3 0.0 3.1 3 0 0 3 3 3 0 Grap2 and cyclin-D-interacting DUF16 PF01519.16 ELR23126.1 - 2.1 8.9 14.7 0.76 10.3 3.9 3.3 3 0 0 3 3 3 0 Protein of unknown function DUF16 DUF3605 PF12239.8 ELR23126.1 - 3.6 7.9 10.0 0.53 10.6 0.2 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF3605) Maf1 PF09174.10 ELR23126.1 - 5.2 7.2 7.1 8.6 6.5 0.0 2.6 3 0 0 3 3 3 0 Maf1 regulator Raco_middle PF17651.1 ELR23126.1 - 6.9 6.3 7.8 8.5 6.0 0.4 2.8 2 1 1 3 3 3 0 RACo middle region Nucleotid_trans PF03407.16 ELR23127.1 - 5.8e-09 36.2 0.1 0.00029 20.9 0.0 2.3 1 1 1 2 2 2 2 Nucleotide-diphospho-sugar transferase EGF PF00008.27 ELR23127.1 - 7.4e-07 29.4 42.9 0.0061 16.8 5.1 4.9 4 1 0 4 4 4 4 EGF-like domain EGF_2 PF07974.13 ELR23127.1 - 4.4e-06 27.0 43.7 0.0024 18.2 4.2 4.5 4 0 0 4 4 4 4 EGF-like domain hEGF PF12661.7 ELR23127.1 - 0.13 12.9 39.7 0.59 10.9 3.8 5.0 4 0 0 4 4 4 0 Human growth factor-like EGF AAA_13 PF13166.6 ELR23128.1 - 0.0012 17.7 14.5 0.0015 17.3 14.5 1.2 1 0 0 1 1 1 1 AAA domain Lebercilin PF15619.6 ELR23128.1 - 0.0095 15.6 27.6 0.0095 15.6 27.6 2.0 1 1 1 2 2 2 1 Ciliary protein causing Leber congenital amaurosis disease Csm1_N PF18504.1 ELR23128.1 - 0.015 15.6 27.8 0.65 10.4 7.6 4.4 1 1 3 4 4 4 0 Csm1 N-terminal domain Exonuc_VII_L PF02601.15 ELR23128.1 - 0.042 13.4 13.7 0.056 13.0 13.7 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit Bap31_Bap29_C PF18035.1 ELR23128.1 - 0.047 13.7 2.0 0.047 13.7 2.0 3.9 3 1 1 4 4 2 0 Bap31/Bap29 cytoplasmic coiled-coil domain TPR_MLP1_2 PF07926.12 ELR23128.1 - 0.05 13.7 30.2 0.19 11.8 26.9 2.4 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein FAM76 PF16046.5 ELR23128.1 - 0.051 12.9 20.6 0.43 9.9 16.9 2.1 1 1 1 2 2 2 0 FAM76 protein Lys-AminoMut_A PF09043.11 ELR23128.1 - 0.054 11.9 2.7 0.055 11.9 2.7 1.1 1 0 0 1 1 1 0 D-Lysine 5,6-aminomutase TIM-barrel domain of alpha subunit Fib_alpha PF08702.10 ELR23128.1 - 0.092 12.9 14.0 0.14 12.3 14.0 1.4 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family Bacillus_HBL PF05791.11 ELR23128.1 - 0.13 12.1 11.4 0.76 9.6 1.5 2.1 1 1 1 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) ERM PF00769.19 ELR23128.1 - 0.13 12.0 32.2 0.17 11.7 32.2 1.1 1 0 0 1 1 1 0 Ezrin/radixin/moesin family Striatin PF08232.12 ELR23128.1 - 0.14 12.7 24.1 0.19 12.3 24.1 1.2 1 0 0 1 1 1 0 Striatin family Golgin_A5 PF09787.9 ELR23128.1 - 0.16 11.4 26.0 1.1 8.7 26.1 1.9 1 1 0 1 1 1 0 Golgin subfamily A member 5 Spc7 PF08317.11 ELR23128.1 - 0.2 10.5 28.5 2.7 6.8 11.1 1.9 1 1 1 2 2 2 0 Spc7 kinetochore protein DUF2203 PF09969.9 ELR23128.1 - 0.25 12.1 18.9 0.77 10.5 2.2 2.5 1 1 2 3 3 3 0 Uncharacterized conserved protein (DUF2203) BRE1 PF08647.11 ELR23128.1 - 0.25 11.4 26.9 1.7 8.8 13.1 2.9 1 1 1 2 2 2 0 BRE1 E3 ubiquitin ligase ADIP PF11559.8 ELR23128.1 - 0.39 10.8 26.8 1.1 9.3 13.4 2.2 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding Baculo_PEP_C PF04513.12 ELR23128.1 - 0.59 10.2 4.7 1.6 8.8 4.3 1.9 1 1 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus CEP63 PF17045.5 ELR23128.1 - 0.64 9.9 27.2 2 8.2 12.3 2.3 1 1 1 2 2 2 0 Centrosomal protein of 63 kDa Tweety PF04906.13 ELR23128.1 - 0.65 8.6 6.4 0.95 8.1 6.4 1.3 1 1 0 1 1 1 0 Tweety WXG100 PF06013.12 ELR23128.1 - 0.74 10.1 9.7 6 7.2 0.5 3.5 1 1 2 4 4 4 0 Proteins of 100 residues with WXG CC2-LZ PF16516.5 ELR23128.1 - 0.77 10.2 26.3 6.5 7.2 10.5 3.4 1 1 2 3 3 3 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator Mod_r PF07200.13 ELR23128.1 - 0.94 9.6 22.5 24 5.0 10.5 2.2 1 1 1 2 2 2 0 Modifier of rudimentary (Mod(r)) protein NPV_P10 PF05531.12 ELR23128.1 - 0.96 10.0 8.3 2.4e+02 2.3 8.3 3.0 1 1 0 1 1 1 0 Nucleopolyhedrovirus P10 protein DUF16 PF01519.16 ELR23128.1 - 1.4 9.5 19.1 30 5.2 7.8 2.3 1 1 1 2 2 2 0 Protein of unknown function DUF16 HIP1_clath_bdg PF16515.5 ELR23128.1 - 1.5 9.5 26.7 2.3 8.9 15.6 2.4 1 1 1 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 TMF_TATA_bd PF12325.8 ELR23128.1 - 1.5 9.1 27.9 3.2 8.0 3.6 3.3 1 1 2 3 3 3 0 TATA element modulatory factor 1 TATA binding DUF1664 PF07889.12 ELR23128.1 - 1.5 8.9 14.6 10 6.2 3.6 2.5 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) DUF489 PF04356.12 ELR23128.1 - 1.7 8.6 7.6 0.46 10.5 2.6 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF489) GAS PF13851.6 ELR23128.1 - 1.8 7.8 28.3 37 3.6 23.6 2.2 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding TPD52 PF04201.15 ELR23128.1 - 1.9 8.1 18.3 2.4 7.8 5.6 2.8 1 1 1 2 2 2 0 Tumour protein D52 family HrpB7 PF09486.10 ELR23128.1 - 1.9 8.8 25.1 15 5.9 1.5 3.1 1 1 1 2 2 2 0 Bacterial type III secretion protein (HrpB7) TMPIT PF07851.13 ELR23128.1 - 2 7.6 18.9 0.61 9.3 10.0 2.0 1 1 1 2 2 2 0 TMPIT-like protein FliD_N PF02465.18 ELR23128.1 - 2.1 9.1 8.4 11 6.7 8.4 2.1 1 1 0 1 1 1 0 Flagellar hook-associated protein 2 N-terminus End3 PF12761.7 ELR23128.1 - 2.3 8.4 21.5 0.96 9.6 4.8 2.6 1 1 2 3 3 3 0 Actin cytoskeleton-regulatory complex protein END3 FUSC PF04632.12 ELR23128.1 - 2.3 6.6 5.9 3 6.3 5.9 1.2 1 0 0 1 1 1 0 Fusaric acid resistance protein family DUF948 PF06103.11 ELR23128.1 - 2.4 8.5 6.8 4.3 7.7 2.5 2.4 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) DUF641 PF04859.12 ELR23128.1 - 2.6 8.4 20.8 3.9 7.8 6.7 2.7 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) FOXP-CC PF16159.5 ELR23128.1 - 2.7 8.7 8.5 0.67 10.6 3.1 2.4 1 1 1 2 2 2 0 FOXP coiled-coil domain LMBR1 PF04791.16 ELR23128.1 - 3.8 6.3 13.3 4.4 6.1 13.3 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein DUF4806 PF16064.5 ELR23128.1 - 3.8 7.9 8.8 6.2 7.2 1.7 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4806) TMF_DNA_bd PF12329.8 ELR23128.1 - 4.2 7.4 36.7 1.7 8.7 3.4 3.6 1 1 2 3 3 3 0 TATA element modulatory factor 1 DNA binding DUF4795 PF16043.5 ELR23128.1 - 4.3 6.9 25.0 6.7 6.2 14.2 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4795) DUF4407 PF14362.6 ELR23128.1 - 4.4 6.6 22.0 34 3.7 21.7 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) DUF812 PF05667.11 ELR23128.1 - 4.6 6.0 26.1 7.9 5.2 26.1 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF812) DUF3552 PF12072.8 ELR23128.1 - 4.6 6.6 35.7 6.4 6.1 6.7 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF3552) APG6_N PF17675.1 ELR23128.1 - 5 7.7 34.9 35 4.9 20.0 2.2 1 1 1 2 2 2 0 Apg6 coiled-coil region Prominin PF05478.11 ELR23128.1 - 5.3 4.9 10.9 8.4 4.2 10.9 1.4 1 1 0 1 1 1 0 Prominin Macoilin PF09726.9 ELR23128.1 - 5.4 5.5 22.0 6.2 5.2 22.0 1.0 1 0 0 1 1 1 0 Macoilin family GrpE PF01025.19 ELR23128.1 - 6.2 6.4 25.2 8.2 6.1 11.7 2.4 1 1 1 2 2 2 0 GrpE FlxA PF14282.6 ELR23128.1 - 6.2 6.9 22.2 1.2 9.2 2.9 2.9 1 1 1 2 2 2 0 FlxA-like protein XLF PF09302.11 ELR23128.1 - 6.5 6.9 14.0 0.31 11.2 0.8 3.1 1 1 2 3 3 3 0 XLF-Cernunnos, XRcc4-like factor, NHEJ component DUF3584 PF12128.8 ELR23128.1 - 7.1 4.0 25.8 12 3.2 25.8 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF3584) Lectin_N PF03954.14 ELR23128.1 - 7.3 6.4 10.0 5 6.9 2.5 2.8 1 1 1 2 2 2 0 Hepatic lectin, N-terminal domain DUF4665 PF15679.5 ELR23128.1 - 7.7 7.2 15.4 11 6.7 2.0 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4665) OmpH PF03938.14 ELR23128.1 - 7.9 6.8 29.4 5.7 7.3 6.3 2.4 1 1 1 2 2 2 0 Outer membrane protein (OmpH-like) NT-C2 PF10358.9 ELR23129.1 - 3.4e-14 52.8 3.2 7.6e-07 29.0 0.0 2.7 3 0 0 3 3 3 2 N-terminal C2 in EEIG1 and EHBP1 proteins MAGE_N PF12440.8 ELR23129.1 - 0.032 14.9 4.5 0.032 14.9 4.5 3.3 3 1 0 3 3 3 0 Melanoma associated antigen family N terminal CDC45 PF02724.14 ELR23129.1 - 0.051 11.9 0.6 0.056 11.7 0.6 1.2 1 0 0 1 1 1 0 CDC45-like protein Apt1 PF10351.9 ELR23129.1 - 0.73 8.6 7.0 1.1 8.0 7.0 1.4 1 1 0 1 1 1 0 Golgi-body localisation protein domain NPR3 PF03666.13 ELR23129.1 - 1.4 7.6 3.5 1.9 7.2 3.5 1.3 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Utp14 PF04615.13 ELR23129.1 - 7.7 5.0 15.6 0.092 11.3 8.0 1.5 2 0 0 2 2 2 0 Utp14 protein 2OG-FeII_Oxy PF03171.20 ELR23130.1 - 3.2e-09 37.2 0.0 6.6e-09 36.2 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily CLU PF13236.6 ELR23131.1 - 3e-36 125.3 0.0 3.6e-36 125.1 0.0 1.1 1 0 0 1 1 1 1 Clustered mitochondria APH PF01636.23 ELR23132.1 - 1.3e-05 25.2 0.3 2.2e-05 24.5 0.1 1.4 2 0 0 2 2 2 1 Phosphotransferase enzyme family RhoGEF PF00621.20 ELR23134.1 - 4.7e-45 154.0 0.4 8.4e-45 153.2 0.4 1.4 1 0 0 1 1 1 1 RhoGEF domain F-box-like PF12937.7 ELR23134.1 - 1.7e-06 27.8 0.2 3.7e-06 26.7 0.2 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ELR23134.1 - 0.00052 19.8 0.0 0.0011 18.8 0.0 1.5 1 0 0 1 1 1 1 F-box domain PH PF00169.29 ELR23134.1 - 0.0023 18.4 0.1 0.015 15.8 0.0 2.5 1 1 1 2 2 2 1 PH domain GrpB PF04229.14 ELR23134.1 - 0.03 14.5 0.2 0.064 13.4 0.2 1.5 1 0 0 1 1 1 0 GrpB protein VSG_B PF13206.6 ELR23134.1 - 0.1 11.8 0.5 11 5.1 0.1 2.1 2 0 0 2 2 2 0 Trypanosomal VSG domain Calpain_III PF01067.22 ELR23135.1 - 0.081 13.2 0.0 0.2 11.9 0.0 1.6 1 0 0 1 1 1 0 Calpain large subunit, domain III Mito_carr PF00153.27 ELR23136.1 - 1.4e-40 137.1 0.3 2.4e-24 85.1 0.0 2.1 2 0 0 2 2 2 2 Mitochondrial carrier protein Pkinase_Tyr PF07714.17 ELR23137.1 - 3e-82 275.8 0.0 1.5e-62 211.2 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 ELR23137.1 - 6.9e-69 232.1 0.0 6.1e-54 183.1 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Guanylate_cyc PF00211.20 ELR23137.1 - 2.6e-13 50.0 0.0 4.2e-13 49.3 0.0 1.2 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain APH PF01636.23 ELR23137.1 - 4.2e-05 23.6 0.3 0.00014 21.8 0.0 2.1 2 0 0 2 2 2 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 ELR23137.1 - 0.011 14.6 0.0 0.029 13.3 0.0 1.5 1 1 1 2 2 2 0 Haspin like kinase domain NurA PF09376.10 ELR23137.1 - 0.13 11.9 0.0 0.23 11.1 0.0 1.2 1 0 0 1 1 1 0 NurA domain Ank_5 PF13857.6 ELR23140.1 - 3e-07 30.6 0.0 6.7e-07 29.5 0.0 1.6 1 1 1 2 2 2 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 ELR23140.1 - 1.7e-05 25.3 0.1 2.7e-05 24.7 0.1 1.3 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ELR23140.1 - 0.00025 21.5 0.0 0.003 18.1 0.0 2.3 1 1 1 2 2 2 1 Ankyrin repeats (many copies) Ank PF00023.30 ELR23140.1 - 0.03 14.8 0.0 0.77 10.3 0.0 2.6 2 0 0 2 2 2 0 Ankyrin repeat Kelch_4 PF13418.6 ELR23141.1 - 0.0056 16.7 11.9 0.08 13.0 0.1 5.1 3 2 2 5 5 5 2 Galactose oxidase, central domain Phage_holin_Dp1 PF16938.5 ELR23141.1 - 0.092 13.0 0.5 16 5.8 0.0 2.7 2 0 0 2 2 2 0 Putative phage holin Dp-1 Kelch_1 PF01344.25 ELR23141.1 - 0.1 12.2 7.6 0.14 11.7 0.1 4.1 3 1 1 4 4 4 0 Kelch motif PP2C_2 PF13672.6 ELR23141.1 - 0.13 11.9 0.1 2.7 7.6 0.0 2.5 1 1 0 1 1 1 0 Protein phosphatase 2C rve PF00665.26 ELR23143.1 - 0.0003 21.0 0.0 0.00047 20.3 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain Tubulin PF00091.25 ELR23146.1 - 2.3e-23 83.5 0.0 3.1e-23 83.0 0.0 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_3 PF14881.6 ELR23146.1 - 2.3e-05 24.2 0.0 3.8e-05 23.4 0.0 1.3 1 0 0 1 1 1 1 Tubulin domain Glyco_hydro_2_C PF02836.17 ELR23147.1 - 2.8e-45 154.7 0.8 4.3e-45 154.1 0.8 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain Glyco_hydro_2_N PF02837.18 ELR23147.1 - 4.9e-20 72.1 0.0 1.3e-19 70.8 0.0 1.7 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, sugar binding domain Glyco_hydro_2 PF00703.21 ELR23147.1 - 0.0012 19.5 0.3 0.0033 18.1 0.2 1.7 1 1 0 1 1 1 1 Glycosyl hydrolases family 2 Mfa_like_1 PF13149.6 ELR23147.1 - 0.044 13.8 0.1 0.063 13.3 0.1 1.2 1 0 0 1 1 1 0 Fimbrillin-like DUF2846 PF11008.8 ELR23147.1 - 0.1 12.6 0.0 0.37 10.8 0.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2846) WD40 PF00400.32 ELR23148.1 - 1.1e-13 51.4 4.7 6.7e-06 26.8 0.1 4.0 4 0 0 4 4 4 3 WD domain, G-beta repeat WD40_like PF17005.5 ELR23148.1 - 0.053 12.8 0.0 0.065 12.6 0.0 1.0 1 0 0 1 1 1 0 WD40-like domain DUF1859 PF08948.10 ELR23148.1 - 0.13 12.3 0.0 0.17 11.8 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1859) FAD_binding_3 PF01494.19 ELR23151.1 - 9.1e-50 169.8 0.0 1.2e-49 169.4 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain MUG113 PF13455.6 ELR23151.1 - 0.1 13.3 0.1 0.39 11.4 0.0 1.9 2 0 0 2 2 2 0 Meiotically up-regulated gene 113 DIT1_PvcA PF05141.12 ELR23152.1 - 2.8e-84 282.9 0.0 3.6e-84 282.5 0.0 1.1 1 0 0 1 1 1 1 Pyoverdine/dityrosine biosynthesis protein TauD PF02668.16 ELR23152.1 - 9.4e-18 65.0 0.1 2.2e-17 63.7 0.1 1.6 1 1 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family MFS_1 PF07690.16 ELR23153.1 - 2e-19 69.7 81.9 2e-11 43.4 56.5 3.7 1 1 2 3 3 3 2 Major Facilitator Superfamily Nodulin-like PF06813.13 ELR23153.1 - 7.9e-13 48.5 13.1 2.4e-09 37.0 6.3 4.1 3 1 1 4 4 4 2 Nodulin-like Sugar_tr PF00083.24 ELR23153.1 - 0.0014 17.6 8.2 0.0014 17.6 8.2 4.0 1 1 1 2 2 2 1 Sugar (and other) transporter Peptidase_S8 PF00082.22 ELR23156.1 - 0.016 14.5 1.4 0.56 9.4 0.5 2.0 1 1 1 2 2 2 0 Subtilase family RB_A PF01858.17 ELR23156.1 - 0.19 11.5 0.0 0.24 11.2 0.0 1.1 1 0 0 1 1 1 0 Retinoblastoma-associated protein A domain Pkinase_Tyr PF07714.17 ELR23157.1 - 1.3e-16 60.7 0.0 1.9e-16 60.1 0.0 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ELR23157.1 - 3.4e-12 46.3 0.0 6.4e-12 45.4 0.0 1.4 2 0 0 2 2 2 1 Protein kinase domain Peptidase_S8 PF00082.22 ELR23157.1 - 0.00085 18.7 0.1 0.0011 18.3 0.1 1.1 1 0 0 1 1 1 1 Subtilase family Abhydrolase_6 PF12697.7 ELR23157.1 - 0.033 14.8 0.1 0.036 14.7 0.1 1.1 1 0 0 1 1 1 0 Alpha/beta hydrolase family Pkinase_Tyr PF07714.17 ELR23158.1 - 1.2e-113 378.7 0.0 5.1e-57 193.1 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 ELR23158.1 - 8.7e-96 320.3 0.0 3.7e-47 160.9 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain 5_nucleotid_C PF02872.18 ELR23158.1 - 1.2e-25 90.5 0.0 2.3e-25 89.7 0.0 1.5 1 0 0 1 1 1 1 5'-nucleotidase, C-terminal domain Guanylate_cyc PF00211.20 ELR23158.1 - 7e-06 25.8 0.0 0.047 13.3 0.1 2.5 1 1 1 2 2 2 2 Adenylate and Guanylate cyclase catalytic domain Kinase-like PF14531.6 ELR23158.1 - 0.0064 15.9 0.1 0.18 11.1 0.0 2.2 2 0 0 2 2 2 1 Kinase-like Haspin_kinase PF12330.8 ELR23158.1 - 0.011 14.7 0.0 3.4 6.5 0.0 2.8 2 1 0 2 2 2 0 Haspin like kinase domain EGF_2 PF07974.13 ELR23158.1 - 0.03 14.7 11.8 0.087 13.2 11.8 1.9 1 0 0 1 1 1 0 EGF-like domain SMRP1 PF15181.6 ELR23158.1 - 0.12 11.9 0.4 0.24 11.0 0.4 1.4 1 0 0 1 1 1 0 Spermatid-specific manchette-related protein 1 EB PF01683.18 ELR23158.1 - 0.26 11.6 4.0 0.66 10.3 3.0 2.2 2 0 0 2 2 2 0 EB module Pkinase_fungal PF17667.1 ELR23158.1 - 0.27 9.9 0.0 12 4.6 0.0 2.1 2 0 0 2 2 2 0 Fungal protein kinase DUF1206 PF06724.11 ELR23158.1 - 0.56 10.3 4.7 7.3 6.7 1.7 3.4 2 0 0 2 2 2 0 Domain of Unknown Function (DUF1206) DUF3346 PF11826.8 ELR23159.1 - 0.06 13.1 2.7 0.1 12.4 2.1 1.6 1 1 0 2 2 2 0 Protein of unknown function (DUF3346) NUDIX PF00293.28 ELR23161.1 - 3e-18 66.1 0.1 1.2e-17 64.2 0.1 2.0 2 0 0 2 2 2 1 NUDIX domain NUDIX-like PF09296.11 ELR23161.1 - 6e-12 46.1 0.1 1.1e-11 45.3 0.1 1.4 1 0 0 1 1 1 1 NADH pyrophosphatase-like rudimentary NUDIX domain zf-NADH-PPase PF09297.11 ELR23161.1 - 2.1e-08 33.6 1.8 2.1e-08 33.6 1.8 1.8 2 0 0 2 2 2 1 NADH pyrophosphatase zinc ribbon domain DNA_ligase_ZBD PF03119.16 ELR23161.1 - 0.42 10.7 3.8 0.21 11.6 1.0 2.0 2 0 0 2 2 2 0 NAD-dependent DNA ligase C4 zinc finger domain DJ-1_PfpI PF01965.24 ELR23164.1 - 3.9e-06 26.8 0.0 8.8e-06 25.6 0.0 1.6 1 1 0 1 1 1 1 DJ-1/PfpI family Actin PF00022.19 ELR23165.1 - 3.8e-81 272.8 0.0 4.5e-80 269.2 0.0 2.1 1 1 0 1 1 1 1 Actin MreB_Mbl PF06723.13 ELR23165.1 - 0.026 13.4 0.0 0.55 9.0 0.0 2.6 3 0 0 3 3 3 0 MreB/Mbl protein DUF563 PF04577.14 ELR23166.1 - 0.00016 21.9 0.0 0.00023 21.4 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF563) Glyco_transf_9 PF01075.17 ELR23166.1 - 0.13 11.6 0.0 0.18 11.0 0.0 1.1 1 0 0 1 1 1 0 Glycosyltransferase family 9 (heptosyltransferase) WD40 PF00400.32 ELR23167.1 - 4.3e-12 46.3 1.2 0.00033 21.4 0.1 6.2 5 1 0 5 5 5 2 WD domain, G-beta repeat F-box-like PF12937.7 ELR23167.1 - 2.7e-10 40.0 0.1 9.1e-10 38.3 0.1 1.9 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ELR23167.1 - 9e-10 38.2 0.1 3.2e-09 36.4 0.0 1.9 2 0 0 2 2 2 1 F-box domain ANAPC4_WD40 PF12894.7 ELR23167.1 - 9e-07 29.1 0.0 0.68 10.3 0.0 4.7 4 1 1 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Fimbrial_PilY2 PF14481.6 ELR23167.1 - 0.0038 16.8 0.0 0.0079 15.8 0.0 1.5 1 0 0 1 1 1 1 Type 4 fimbrial biogenesis protein PilY2 Nup160 PF11715.8 ELR23167.1 - 0.009 14.7 0.0 0.015 14.0 0.0 1.3 1 0 0 1 1 1 1 Nucleoporin Nup120/160 RAB3GAP2_N PF14655.6 ELR23167.1 - 0.052 12.8 0.0 0.082 12.2 0.0 1.3 1 0 0 1 1 1 0 Rab3 GTPase-activating protein regulatory subunit N-terminus Erg28 PF03694.13 ELR23168.1 - 3.2e-26 91.9 0.4 4.4e-26 91.4 0.4 1.1 1 0 0 1 1 1 1 Erg28 like protein MscS_TM PF12794.7 ELR23168.1 - 0.0025 16.8 0.1 0.0026 16.7 0.1 1.0 1 0 0 1 1 1 1 Mechanosensitive ion channel inner membrane domain 1 Pyr_excise PF03013.14 ELR23169.1 - 0.081 12.9 0.2 0.23 11.5 0.0 1.8 2 0 0 2 2 2 0 Pyrimidine dimer DNA glycosylase Ribosomal_60s PF00428.19 ELR23169.1 - 5.6 7.6 14.2 5.4 7.7 9.2 2.9 1 1 1 2 2 2 0 60s Acidic ribosomal protein Complex1_LYR_2 PF13233.6 ELR23170.1 - 0.0005 20.8 0.0 0.00074 20.2 0.0 1.3 1 0 0 1 1 1 1 Complex1_LYR-like RasGEF PF00617.19 ELR23171.1 - 4.7e-56 189.8 0.2 7.1e-56 189.2 0.2 1.3 1 0 0 1 1 1 1 RasGEF domain LMF1 PF06762.14 ELR23171.1 - 1.5e-44 152.9 0.4 5.1e-44 151.1 0.9 1.8 2 1 0 2 2 2 1 Lipase maturation factor Imm41 PF15592.6 ELR23171.1 - 0.35 11.2 3.3 0.25 11.7 1.3 1.7 2 0 0 2 2 2 0 Immunity protein 41 Tower PF09121.10 ELR23172.1 - 0.26 11.5 1.2 0.71 10.1 0.5 1.9 2 0 0 2 2 2 0 Tower V-SNARE_C PF12352.8 ELR23173.1 - 6.7e-09 35.9 3.8 1.4e-08 34.9 0.8 2.0 1 1 1 2 2 2 2 Snare region anchored in the vesicle membrane C-terminus PhyH PF05721.13 ELR23174.1 - 6.5e-16 59.2 0.0 9.6e-16 58.7 0.0 1.3 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) AOX PF01786.17 ELR23175.1 - 4.2e-94 314.1 0.2 5.7e-94 313.7 0.2 1.2 1 0 0 1 1 1 1 Alternative oxidase Endomucin PF07010.12 ELR23175.1 - 0.17 11.8 9.6 0.24 11.3 9.6 1.1 1 0 0 1 1 1 0 Endomucin Med3 PF11593.8 ELR23175.1 - 3.5 6.7 11.7 4.7 6.3 11.7 1.2 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal Pkinase PF00069.25 ELR23177.1 - 5.3e-67 226.0 0.0 7.4e-67 225.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR23177.1 - 1.9e-37 129.0 0.0 2.5e-37 128.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ELR23177.1 - 2.6e-07 30.2 0.0 7.2e-07 28.8 0.0 1.5 1 1 0 1 1 1 1 Kinase-like APH PF01636.23 ELR23177.1 - 1.8e-06 28.1 0.0 0.035 14.0 0.0 2.2 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.14 ELR23177.1 - 8.1e-05 22.1 0.0 0.00013 21.4 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 ELR23177.1 - 0.00024 20.2 0.1 0.00033 19.7 0.1 1.2 1 0 0 1 1 1 1 Haspin like kinase domain Pkinase_fungal PF17667.1 ELR23177.1 - 0.0021 16.9 0.2 0.0047 15.8 0.1 1.5 1 1 0 1 1 1 1 Fungal protein kinase FTA2 PF13095.6 ELR23177.1 - 0.02 14.5 0.1 0.062 12.9 0.0 1.7 1 1 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 YrbL-PhoP_reg PF10707.9 ELR23177.1 - 0.042 13.4 0.0 0.36 10.3 0.0 2.0 2 0 0 2 2 2 0 PhoP regulatory network protein YrbL BORCS7 PF16088.5 ELR23178.1 - 1.7e-11 44.3 0.0 2e-11 44.0 0.0 1.0 1 0 0 1 1 1 1 BLOC-1-related complex sub-unit 7 Aldedh PF00171.22 ELR23179.1 - 5.6e-158 526.2 0.1 2e-95 320.0 0.1 2.0 2 0 0 2 2 2 2 Aldehyde dehydrogenase family cobW PF02492.19 ELR23180.1 - 1.1e-48 165.2 4.5 1.1e-47 162.0 4.5 2.1 1 1 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain CobW_C PF07683.14 ELR23180.1 - 3.1e-21 75.1 0.1 9.2e-21 73.6 0.1 1.9 1 0 0 1 1 1 1 Cobalamin synthesis protein cobW C-terminal domain RsgA_GTPase PF03193.16 ELR23180.1 - 0.004 17.1 0.2 2.7 7.9 0.0 2.3 2 0 0 2 2 2 2 RsgA GTPase T2SSE PF00437.20 ELR23180.1 - 0.0091 15.1 0.0 0.015 14.4 0.0 1.3 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_22 PF13401.6 ELR23180.1 - 0.012 15.9 0.1 0.047 14.0 0.1 2.1 1 1 0 1 1 1 0 AAA domain AAA_16 PF13191.6 ELR23180.1 - 0.04 14.3 0.0 0.23 11.8 0.0 2.2 2 0 0 2 2 2 0 AAA ATPase domain DUF3727 PF12527.8 ELR23180.1 - 0.055 13.7 0.0 0.39 11.0 0.1 2.4 3 0 0 3 3 3 0 Protein of unknown function (DUF3727) ATPase_2 PF01637.18 ELR23180.1 - 0.1 12.5 0.2 0.34 10.8 0.1 1.9 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea MMR_HSR1 PF01926.23 ELR23180.1 - 0.12 12.5 0.9 2.4 8.3 0.2 2.6 2 0 0 2 2 2 0 50S ribosome-binding GTPase Zeta_toxin PF06414.12 ELR23180.1 - 0.17 11.1 0.0 0.34 10.1 0.0 1.5 1 0 0 1 1 1 0 Zeta toxin CENP-Q PF13094.6 ELR23182.1 - 4.5e-07 30.2 13.0 1.1e-06 28.9 13.0 1.6 1 1 0 1 1 1 1 CENP-Q, a CENPA-CAD centromere complex subunit COG5 PF10392.9 ELR23182.1 - 0.011 15.8 4.1 0.022 14.9 4.1 1.5 1 0 0 1 1 1 0 Golgi transport complex subunit 5 S6OS1 PF15676.5 ELR23182.1 - 0.013 14.0 1.7 0.017 13.6 1.7 1.1 1 0 0 1 1 1 0 Six6 opposite strand transcript 1 family Exonuc_VII_L PF02601.15 ELR23182.1 - 0.054 13.1 3.7 0.067 12.8 3.7 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit FliJ PF02050.16 ELR23182.1 - 0.1 12.8 10.0 0.23 11.7 10.0 1.5 1 0 0 1 1 1 0 Flagellar FliJ protein kleA_kleC PF17383.2 ELR23182.1 - 0.11 12.8 3.1 4.3 7.7 2.5 2.6 2 0 0 2 2 2 0 Uncharacterized KorC regulated protein A FapA PF03961.13 ELR23182.1 - 0.19 10.3 2.0 0.24 9.9 2.0 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A DUF641 PF04859.12 ELR23182.1 - 0.25 11.7 7.4 0.43 10.9 7.4 1.3 1 0 0 1 1 1 0 Plant protein of unknown function (DUF641) V_ATPase_I PF01496.19 ELR23182.1 - 0.56 8.1 1.7 0.6 8.0 1.7 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Spc7 PF08317.11 ELR23182.1 - 1.2 8.0 10.7 1 8.2 8.0 2.0 2 1 0 2 2 2 0 Spc7 kinetochore protein Fzo_mitofusin PF04799.13 ELR23182.1 - 1.2 8.7 7.6 8.6 5.9 7.6 2.1 1 1 0 1 1 1 0 fzo-like conserved region COG2 PF06148.11 ELR23182.1 - 1.8 8.7 9.1 1.2 9.2 5.9 2.3 3 1 0 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 DUF4404 PF14357.6 ELR23182.1 - 2 9.1 10.1 7.5 7.3 0.2 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF4404) FYVE_2 PF02318.16 ELR23182.1 - 3.1 8.0 5.1 1.2 9.4 2.3 1.6 2 0 0 2 2 2 0 FYVE-type zinc finger FemAB PF02388.16 ELR23182.1 - 8 5.2 6.8 7.6 5.3 5.5 1.5 2 0 0 2 2 2 0 FemAB family AAA_23 PF13476.6 ELR23182.1 - 8.1 6.9 10.7 10 6.6 9.6 1.6 1 1 1 2 2 2 0 AAA domain BLOC1_2 PF10046.9 ELR23183.1 - 2.3e-32 111.1 5.1 3.2e-32 110.7 5.1 1.2 1 0 0 1 1 1 1 Biogenesis of lysosome-related organelles complex-1 subunit 2 KASH_CCD PF14662.6 ELR23183.1 - 0.0024 17.7 4.1 0.0024 17.7 4.1 1.5 1 1 0 1 1 1 1 Coiled-coil region of CCDC155 or KASH LOH1CR12 PF10158.9 ELR23183.1 - 0.0041 17.2 2.5 0.0078 16.2 2.5 1.5 1 1 0 1 1 1 1 Tumour suppressor protein SlyX PF04102.12 ELR23183.1 - 0.019 15.5 1.5 1.3 9.7 0.2 2.4 2 0 0 2 2 2 0 SlyX TetR_C_4 PF08359.11 ELR23183.1 - 0.026 14.7 0.5 0.066 13.4 0.1 1.8 1 1 1 2 2 2 0 YsiA-like protein, C-terminal region CENP-O PF09496.10 ELR23183.1 - 0.038 14.0 0.5 0.042 13.8 0.5 1.2 1 0 0 1 1 1 0 Cenp-O kinetochore centromere component DUF2138 PF09909.9 ELR23183.1 - 0.04 12.2 0.0 0.05 11.9 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2138) Med9 PF07544.13 ELR23183.1 - 0.082 13.0 1.7 0.087 12.9 0.6 1.6 2 0 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 HSBP1 PF06825.12 ELR23183.1 - 4.6 7.2 7.5 1.4 8.9 0.9 3.2 2 1 2 4 4 4 0 Heat shock factor binding protein 1 Ge1_WD40 PF16529.5 ELR23184.1 - 5.5e-20 71.6 0.0 1.1e-18 67.3 0.0 2.5 1 1 0 1 1 1 1 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40 PF00400.32 ELR23184.1 - 5.1e-09 36.6 1.9 0.064 14.1 0.0 4.7 4 1 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ELR23184.1 - 0.0015 18.7 0.2 0.077 13.3 0.0 3.1 2 1 1 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain DUF1454 PF07305.12 ELR23185.1 - 0.14 11.6 0.0 0.19 11.2 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1454) SPATA25 PF15218.6 ELR23188.1 - 0.11 12.3 0.1 0.12 12.1 0.1 1.1 1 0 0 1 1 1 0 Spermatogenesis-associated protein 25 LodA_N PF17990.1 ELR23188.1 - 0.12 12.3 1.5 0.13 12.2 1.5 1.0 1 0 0 1 1 1 0 L-Lysine epsilon oxidase N-terminal GST_C_2 PF13410.6 ELR23189.1 - 0.077 13.0 0.0 0.22 11.6 0.0 1.8 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain SMC_ScpB PF04079.16 ELR23189.1 - 0.17 11.5 0.0 0.28 10.8 0.0 1.3 1 0 0 1 1 1 0 Segregation and condensation complex subunit ScpB CBS PF00571.28 ELR23193.1 - 1.7e-27 95.6 9.1 2.5e-07 31.0 0.0 4.4 4 0 0 4 4 4 4 CBS domain Ank_2 PF12796.7 ELR23194.1 - 1.5e-37 128.1 5.5 1.9e-14 54.0 0.1 4.1 2 1 2 4 4 4 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ELR23194.1 - 1.1e-34 118.4 6.1 2.2e-10 40.8 0.2 6.2 2 2 3 6 6 6 6 Ankyrin repeats (many copies) Ank PF00023.30 ELR23194.1 - 9.4e-34 114.4 12.1 4.5e-08 33.2 0.6 6.7 7 0 0 7 7 7 5 Ankyrin repeat Ank_5 PF13857.6 ELR23194.1 - 2.3e-31 107.4 14.5 4e-08 33.4 0.9 7.0 2 2 5 7 7 7 7 Ankyrin repeats (many copies) Ank_3 PF13606.6 ELR23194.1 - 2.3e-26 88.9 10.0 0.00087 19.6 0.1 8.0 9 0 0 9 9 9 5 Ankyrin repeat DUF4149 PF13664.6 ELR23195.1 - 0.51 10.7 4.2 13 6.1 0.3 3.0 3 1 0 3 3 3 0 Domain of unknown function (DUF4149) DHR-2 PF06920.13 ELR23197.1 - 5.4e-68 229.9 4.1 8.4e-68 229.3 1.7 2.0 2 0 0 2 2 2 1 Dock homology region 2 DOCK-C2 PF14429.6 ELR23197.1 - 5.7e-33 114.4 0.1 1.5e-32 113.0 0.0 1.8 2 0 0 2 2 2 1 C2 domain in Dock180 and Zizimin proteins DUF3398 PF11878.8 ELR23197.1 - 6.1e-06 26.6 0.1 1.5e-05 25.4 0.1 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF3398) IBN_N PF03810.19 ELR23197.1 - 0.015 15.2 1.4 1.9 8.5 0.0 3.3 3 0 0 3 3 3 0 Importin-beta N-terminal domain DHR-2 PF06920.13 ELR23198.1 - 8.3e-59 199.6 0.1 9.2e-59 199.5 0.1 1.0 1 0 0 1 1 1 1 Dock homology region 2 DUF4988 PF16378.5 ELR23198.1 - 0.11 12.1 0.0 0.16 11.6 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function Pro_isomerase PF00160.21 ELR23199.1 - 2.8e-41 141.4 0.0 7.9e-41 140.0 0.0 1.8 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD DHR-2 PF06920.13 ELR23200.1 - 4e-81 273.3 7.2 2.2e-80 270.8 7.2 2.0 1 1 0 1 1 1 1 Dock homology region 2 DOCK_N PF16172.5 ELR23200.1 - 7e-56 189.8 0.0 1.4e-55 188.7 0.0 1.4 1 0 0 1 1 1 1 DOCK N-terminus DOCK-C2 PF14429.6 ELR23200.1 - 6.4e-34 117.5 0.0 2e-32 112.6 0.0 2.6 2 0 0 2 2 2 1 C2 domain in Dock180 and Zizimin proteins SH3_2 PF07653.17 ELR23200.1 - 0.0012 18.5 0.0 0.048 13.4 0.0 2.5 2 0 0 2 2 2 1 Variant SH3 domain SH3_9 PF14604.6 ELR23200.1 - 0.021 14.6 0.0 0.071 13.0 0.0 1.9 1 0 0 1 1 1 0 Variant SH3 domain SH3_1 PF00018.28 ELR23200.1 - 0.056 13.1 0.0 0.6 9.8 0.0 2.3 2 0 0 2 2 2 0 SH3 domain Actin PF00022.19 ELR23202.1 - 1.3e-154 514.7 0.0 4.2e-154 513.1 0.0 1.6 1 1 0 1 1 1 1 Actin DUF677 PF05055.12 ELR23203.1 - 0.17 10.7 7.9 0.26 10.1 7.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF677) Colicin PF01024.19 ELR23203.1 - 0.19 11.6 2.8 0.39 10.6 2.8 1.5 1 0 0 1 1 1 0 Colicin pore forming domain DC_STAMP PF07782.13 ELR23203.1 - 0.3 10.9 1.5 0.54 10.1 0.0 2.1 1 1 0 2 2 2 0 DC-STAMP-like protein Tic110 PF16940.5 ELR23203.1 - 3 6.2 9.5 4.1 5.8 9.5 1.1 1 0 0 1 1 1 0 Chloroplast envelope transporter DUF4231 PF14015.6 ELR23203.1 - 5.9 7.4 10.0 12 6.5 8.9 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF4231) UPF0182 PF03699.13 ELR23203.1 - 6.2 4.8 8.2 6.9 4.7 8.2 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0182) Fusion_gly PF00523.18 ELR23203.1 - 6.5 4.9 6.9 9.3 4.4 6.9 1.2 1 0 0 1 1 1 0 Fusion glycoprotein F0 ArfGap PF01412.18 ELR23204.1 - 3.9e-26 91.4 1.2 1.3e-25 89.8 0.2 2.5 1 1 1 2 2 2 1 Putative GTPase activating protein for Arf PH PF00169.29 ELR23204.1 - 3.6e-06 27.4 1.7 0.00076 20.0 1.0 3.0 2 0 0 2 2 2 2 PH domain PH_11 PF15413.6 ELR23204.1 - 0.029 14.8 1.4 0.66 10.4 0.1 3.1 3 0 0 3 3 3 0 Pleckstrin homology domain MFS_1 PF07690.16 ELR23205.1 - 4.7e-35 121.2 35.4 4.7e-35 121.2 35.4 1.9 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF5373 PF17343.2 ELR23205.1 - 0.75 9.6 5.4 1.8 8.4 5.4 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5373) WD40 PF00400.32 ELR23206.1 - 1.9e-17 63.3 8.6 9.5e-05 23.1 0.0 5.7 5 0 0 5 5 5 5 WD domain, G-beta repeat Ribosomal_S19 PF00203.21 ELR23207.1 - 1.3e-35 121.1 0.4 1.6e-35 120.8 0.4 1.1 1 0 0 1 1 1 1 Ribosomal protein S19 MDM10 PF12519.8 ELR23208.1 - 7e-13 48.3 1.2 7e-13 48.3 1.2 2.0 1 1 0 2 2 2 1 Mitochondrial distribution and morphology protein 10 Porin_3 PF01459.22 ELR23208.1 - 3.9e-09 36.4 0.3 5.4e-09 35.9 0.3 1.1 1 0 0 1 1 1 1 Eukaryotic porin TrfA PF07042.11 ELR23208.1 - 0.12 11.4 0.0 0.18 10.8 0.0 1.1 1 0 0 1 1 1 0 TrfA protein NOA36 PF06524.12 ELR23208.1 - 0.13 11.5 1.0 0.2 11.0 1.0 1.1 1 0 0 1 1 1 0 NOA36 protein PBP_sp32 PF07222.12 ELR23208.1 - 2.1 7.7 5.1 4.3 6.7 5.1 1.5 1 0 0 1 1 1 0 Proacrosin binding protein sp32 PH PF00169.29 ELR23209.1 - 0.0011 19.4 0.1 0.0024 18.3 0.1 1.6 1 0 0 1 1 1 1 PH domain PH_11 PF15413.6 ELR23209.1 - 0.037 14.4 0.1 0.19 12.2 0.1 2.2 1 0 0 1 1 1 0 Pleckstrin homology domain ArfGap PF01412.18 ELR23210.1 - 1.6e-33 115.3 0.4 1.6e-33 115.3 0.4 3.1 2 1 0 2 2 2 1 Putative GTPase activating protein for Arf TFIIA PF03153.13 ELR23210.1 - 0.85 9.6 37.4 0.078 13.0 29.8 2.2 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Condensation PF00668.20 ELR23211.1 - 7.7e-08 31.4 0.0 0.00055 18.7 0.0 3.0 3 0 0 3 3 3 3 Condensation domain Mito_carr PF00153.27 ELR23212.1 - 7.7e-09 35.4 0.2 4.8e-08 32.8 0.0 2.4 2 1 0 2 2 2 1 Mitochondrial carrier protein RhoGAP PF00620.27 ELR23213.1 - 3.1e-28 98.5 0.0 5.5e-28 97.7 0.0 1.4 1 0 0 1 1 1 1 RhoGAP domain MyTH4 PF00784.17 ELR23213.1 - 4.2e-26 91.5 0.6 8.8e-26 90.5 0.6 1.6 1 0 0 1 1 1 1 MyTH4 domain GREB1 PF15782.5 ELR23218.1 - 3.2 4.8 15.2 3.9 4.5 15.2 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer BUD22 PF09073.10 ELR23218.1 - 3.2 7.0 29.0 5.1 6.3 29.0 1.3 1 0 0 1 1 1 0 BUD22 LAP1C PF05609.12 ELR23218.1 - 7.3 5.6 23.0 10 5.1 23.0 1.3 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) G-patch PF01585.23 ELR23219.1 - 1.6e-15 56.7 2.9 4.1e-15 55.4 2.9 1.8 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.7 ELR23219.1 - 1.5e-08 34.6 1.2 1.5e-08 34.6 1.2 4.8 4 1 0 4 4 4 1 G-patch domain START PF01852.19 ELR23220.1 - 3.4e-11 43.0 0.1 1.6e-10 40.7 0.1 1.9 1 1 0 1 1 1 1 START domain Polyketide_cyc PF03364.20 ELR23220.1 - 0.043 14.0 0.0 0.13 12.4 0.0 1.9 1 0 0 1 1 1 0 Polyketide cyclase / dehydrase and lipid transport U79_P34 PF03064.16 ELR23220.1 - 0.15 11.4 0.1 0.15 11.4 0.1 2.3 2 0 0 2 2 2 0 HSV U79 / HCMV P34 Vpu PF00558.19 ELR23220.1 - 0.82 9.5 2.9 2 8.2 2.9 1.6 1 0 0 1 1 1 0 Vpu protein DHR-2 PF06920.13 ELR23221.1 - 6.5e-77 259.4 1.3 3.5e-76 257.0 1.3 1.9 1 1 0 1 1 1 1 Dock homology region 2 DOCK_N PF16172.5 ELR23221.1 - 3.4e-47 161.2 0.0 1.5e-46 159.0 0.0 2.1 1 1 0 1 1 1 1 DOCK N-terminus DOCK-C2 PF14429.6 ELR23221.1 - 2.1e-44 151.6 0.0 1.6e-43 148.8 0.0 2.2 2 0 0 2 2 2 1 C2 domain in Dock180 and Zizimin proteins SH3_1 PF00018.28 ELR23221.1 - 1e-06 28.2 0.0 2.2e-06 27.2 0.0 1.6 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 ELR23221.1 - 3.4e-06 26.8 0.0 7.5e-06 25.7 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 ELR23221.1 - 1.7e-05 24.4 0.0 4.9e-05 22.9 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain Clathrin PF00637.20 ELR23221.1 - 0.09 12.7 1.5 3.7 7.4 0.1 3.0 2 0 0 2 2 2 0 Region in Clathrin and VPS Dioxygenase_N PF04444.14 ELR23221.1 - 0.32 10.9 1.5 5.1 7.0 0.0 3.5 4 0 0 4 4 4 0 Catechol dioxygenase N terminus Phage_holin_3_6 PF07332.11 ELR23222.1 - 0.019 15.0 0.1 0.019 15.0 0.1 3.3 2 1 1 3 3 3 0 Putative Actinobacterial Holin-X, holin superfamily III DUF4718 PF15842.5 ELR23222.1 - 0.52 10.1 4.9 1.6 8.5 4.9 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4718) Clc-like PF07062.12 ELR23222.1 - 2.1 7.8 5.4 2.1 7.8 1.3 2.2 2 0 0 2 2 2 0 Clc-like TraL PF07178.11 ELR23222.1 - 3.6 8.1 5.0 24 5.5 0.0 2.9 3 0 0 3 3 3 0 TraL protein Arf PF00025.21 ELR23223.1 - 9.7e-62 207.5 0.1 1.2e-61 207.2 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 ELR23223.1 - 2.1e-12 47.3 0.0 3.3e-12 46.7 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 ELR23223.1 - 1.9e-10 40.5 0.0 2.6e-10 40.0 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Ras PF00071.22 ELR23223.1 - 1.9e-09 37.3 0.0 2.2e-09 37.1 0.0 1.1 1 0 0 1 1 1 1 Ras family G-alpha PF00503.20 ELR23223.1 - 2.3e-07 30.3 0.2 0.0003 20.0 0.0 2.1 1 1 1 2 2 2 2 G-protein alpha subunit Gtr1_RagA PF04670.12 ELR23223.1 - 1.6e-06 27.7 0.0 1.9e-06 27.4 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 ELR23223.1 - 0.011 15.8 0.0 0.02 14.9 0.0 1.4 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_22 PF13401.6 ELR23223.1 - 0.011 16.0 0.2 0.08 13.2 0.1 2.3 1 1 1 2 2 2 0 AAA domain 6PF2K PF01591.18 ELR23223.1 - 0.061 12.6 0.0 0.093 12.0 0.0 1.2 1 0 0 1 1 1 0 6-phosphofructo-2-kinase NACHT PF05729.12 ELR23223.1 - 0.094 12.6 0.2 0.98 9.3 0.2 2.1 1 1 0 1 1 1 0 NACHT domain Acyltransferase PF01553.21 ELR23224.1 - 2.8e-06 27.0 0.0 7.5e-06 25.6 0.0 1.9 1 1 0 1 1 1 1 Acyltransferase ANAPC4_WD40 PF12894.7 ELR23225.1 - 5.8e-15 55.4 0.0 0.0011 19.2 0.0 4.6 3 1 2 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Synaptobrevin PF00957.21 ELR23225.1 - 6e-11 42.0 1.0 1.3e-10 40.9 1.0 1.5 1 0 0 1 1 1 1 Synaptobrevin WD40 PF00400.32 ELR23225.1 - 2.1e-08 34.7 4.9 0.002 18.9 0.0 6.5 6 0 0 6 6 6 1 WD domain, G-beta repeat Lgl_C PF08596.10 ELR23225.1 - 0.0012 17.7 0.0 0.0056 15.4 0.0 2.1 3 0 0 3 3 3 1 Lethal giant larvae(Lgl) like, C-terminal ELYS-bb PF16687.5 ELR23225.1 - 0.061 11.9 0.0 9.2 4.7 0.0 2.8 2 1 1 3 3 3 0 beta-propeller of ELYS nucleoporin CNH PF00780.22 ELR23225.1 - 0.088 12.4 0.4 5.5 6.5 0.0 3.0 2 1 1 3 3 3 0 CNH domain WD40_like PF17005.5 ELR23225.1 - 0.13 11.5 0.0 0.36 10.1 0.0 1.6 2 0 0 2 2 2 0 WD40-like domain MAPEG PF01124.18 ELR23226.1 - 3.2e-11 43.2 0.5 3.2e-11 43.2 0.5 1.6 2 0 0 2 2 2 1 MAPEG family TRP PF06011.12 ELR23226.1 - 0.57 8.8 6.8 0.026 13.3 1.6 1.3 2 0 0 2 2 2 0 Transient receptor potential (TRP) ion channel FKBP_C PF00254.28 ELR23227.1 - 3.2e-28 97.9 0.0 8.4e-28 96.5 0.0 1.6 2 0 0 2 2 2 1 FKBP-type peptidyl-prolyl cis-trans isomerase FKBP_N PF01346.18 ELR23227.1 - 1.4e-07 32.3 0.1 1.4e-07 32.3 0.1 1.7 2 0 0 2 2 2 1 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase Ribosomal_60s PF00428.19 ELR23227.1 - 0.1 13.2 1.1 2.6 8.7 0.1 2.1 2 0 0 2 2 2 0 60s Acidic ribosomal protein Exo_endo_phos PF03372.23 ELR23228.1 - 9.5e-12 44.9 0.0 2e-11 43.9 0.0 1.7 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family AF-4 PF05110.13 ELR23228.1 - 0.017 13.3 4.0 0.021 13.0 4.0 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein Cwf_Cwc_15 PF04889.12 ELR23228.1 - 0.15 11.8 2.1 0.25 11.0 2.1 1.3 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein CENP-B_dimeris PF09026.10 ELR23228.1 - 8.5 6.8 9.9 30 5.1 7.2 2.2 2 0 0 2 2 2 0 Centromere protein B dimerisation domain LTD PF00932.19 ELR23229.1 - 3.7e-16 59.5 0.2 1.4e-08 35.1 0.0 2.7 2 1 0 2 2 2 2 Lamin Tail Domain NAM-associated PF14303.6 ELR23229.1 - 0.051 14.3 1.5 0.15 12.8 1.5 1.7 1 1 0 1 1 1 0 No apical meristem-associated C-terminal domain Pyridoxal_deC PF00282.19 ELR23230.1 - 3.3e-20 72.1 0.0 5.2e-20 71.5 0.0 1.2 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Aminotran_5 PF00266.19 ELR23230.1 - 1.4e-10 40.7 0.0 3.4e-10 39.4 0.0 1.6 1 1 0 1 1 1 1 Aminotransferase class-V DegT_DnrJ_EryC1 PF01041.17 ELR23230.1 - 1.6e-10 40.9 0.3 2.7e-10 40.1 0.3 1.3 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family DNA_ligase_A_M PF01068.21 ELR23230.1 - 0.0038 16.9 0.0 0.0061 16.2 0.0 1.2 1 0 0 1 1 1 1 ATP dependent DNA ligase domain Aminotran_1_2 PF00155.21 ELR23230.1 - 0.02 14.1 0.1 0.068 12.3 0.0 1.8 2 0 0 2 2 2 0 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.20 ELR23230.1 - 0.062 11.8 0.0 0.099 11.2 0.0 1.2 1 0 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme AA_permease_2 PF13520.6 ELR23231.1 - 7.5e-36 123.9 34.1 9.6e-36 123.5 34.1 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 ELR23231.1 - 9.6e-23 80.5 29.0 1.5e-22 79.9 28.4 1.5 1 1 0 1 1 1 1 Amino acid permease Pkinase_Tyr PF07714.17 ELR23232.1 - 6.2e-32 110.9 0.0 4e-16 59.1 0.0 2.2 1 1 1 2 2 2 2 Protein tyrosine kinase SPRY PF00622.28 ELR23232.1 - 2.1e-31 108.5 0.0 7e-20 71.3 0.1 2.8 2 1 0 2 2 2 2 SPRY domain Pkinase PF00069.25 ELR23232.1 - 1.6e-23 83.4 0.0 1.8e-10 40.6 0.0 2.3 1 1 1 2 2 2 2 Protein kinase domain SAM_1 PF00536.30 ELR23232.1 - 1.8e-16 60.3 0.1 3.7e-16 59.3 0.1 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 ELR23232.1 - 7.8e-16 57.9 0.0 1.4e-15 57.1 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_Ste50p PF09235.10 ELR23232.1 - 0.044 14.0 0.0 0.11 12.8 0.0 1.6 1 0 0 1 1 1 0 Ste50p, sterile alpha motif Glyco_hydro_2_N PF02837.18 ELR23233.1 - 0.013 15.4 0.0 0.016 15.2 0.0 1.2 1 0 0 1 1 1 0 Glycosyl hydrolases family 2, sugar binding domain BetaGal_dom4_5 PF13364.6 ELR23233.1 - 0.045 14.3 0.0 0.066 13.8 0.0 1.2 1 0 0 1 1 1 0 Beta-galactosidase jelly roll domain Ig_mannosidase PF17753.1 ELR23234.1 - 5.9e-14 51.6 0.0 1.2e-13 50.6 0.0 1.5 1 0 0 1 1 1 1 Ig-fold domain Mannosidase_ig PF17786.1 ELR23234.1 - 2.1e-10 41.1 0.0 4.4e-10 40.0 0.0 1.6 1 0 0 1 1 1 1 Mannosidase Ig/CBM-like domain Glyco_hydro_2_C PF02836.17 ELR23234.1 - 2.3e-08 33.5 0.0 9e-08 31.6 0.0 1.9 1 1 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain Glyco_hydro_2 PF00703.21 ELR23234.1 - 0.019 15.6 0.0 0.05 14.3 0.0 1.7 1 0 0 1 1 1 0 Glycosyl hydrolases family 2 Pkinase_Tyr PF07714.17 ELR23235.1 - 6.3e-106 353.4 0.0 1.8e-62 211.0 0.0 2.9 2 1 1 3 3 3 2 Protein tyrosine kinase Pkinase PF00069.25 ELR23235.1 - 4e-95 318.1 0.0 5.4e-57 193.2 0.0 2.4 2 0 0 2 2 2 2 Protein kinase domain SH2 PF00017.24 ELR23235.1 - 7.6e-10 38.8 0.0 1.8e-09 37.5 0.0 1.6 1 0 0 1 1 1 1 SH2 domain PIP49_C PF12260.8 ELR23235.1 - 0.00028 20.6 0.0 0.0067 16.1 0.0 2.4 2 0 0 2 2 2 1 Protein-kinase domain of FAM69 APH PF01636.23 ELR23235.1 - 0.00099 19.1 1.2 1.8 8.4 0.0 2.8 2 0 0 2 2 2 2 Phosphotransferase enzyme family Haspin_kinase PF12330.8 ELR23235.1 - 0.0013 17.8 0.6 2.4 7.0 0.0 3.3 3 0 0 3 3 3 2 Haspin like kinase domain Seadorna_VP7 PF07387.11 ELR23235.1 - 0.0037 16.4 0.0 1.7 7.6 0.1 2.4 2 0 0 2 2 2 2 Seadornavirus VP7 Pkinase_fungal PF17667.1 ELR23235.1 - 0.051 12.4 0.1 4.2 6.0 0.2 2.7 3 0 0 3 3 3 0 Fungal protein kinase MutS_III PF05192.18 ELR23237.1 - 0.0013 19.0 0.1 0.0015 18.8 0.1 1.0 1 0 0 1 1 1 1 MutS domain III Pro-rich_19 PF15455.6 ELR23237.1 - 0.027 13.6 0.1 0.029 13.5 0.1 1.1 1 0 0 1 1 1 0 Proline-rich 19 MutS_V PF00488.21 ELR23238.1 - 7.5e-71 238.1 0.0 1.7e-70 236.9 0.0 1.6 2 0 0 2 2 2 1 MutS domain V AAA_27 PF13514.6 ELR23238.1 - 0.00066 19.3 0.2 0.0026 17.4 0.0 1.9 2 0 0 2 2 2 1 AAA domain AAA_23 PF13476.6 ELR23238.1 - 0.019 15.5 0.2 0.26 11.8 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_29 PF13555.6 ELR23238.1 - 0.032 14.0 0.0 0.061 13.1 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_14 PF13173.6 ELR23238.1 - 0.039 14.0 0.0 0.11 12.5 0.0 1.8 1 0 0 1 1 1 0 AAA domain ATPase_2 PF01637.18 ELR23238.1 - 0.07 13.0 0.0 0.19 11.6 0.0 1.7 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_22 PF13401.6 ELR23238.1 - 0.082 13.2 0.0 0.75 10.1 0.0 2.3 2 0 0 2 2 2 0 AAA domain SMC_N PF02463.19 ELR23238.1 - 0.11 11.9 0.0 0.7 9.3 0.0 2.1 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain MutS_III PF05192.18 ELR23238.1 - 0.6 10.3 4.5 0.67 10.1 0.2 2.4 2 1 0 2 2 2 0 MutS domain III DAGK_cat PF00781.24 ELR23239.1 - 4.4e-29 100.7 0.0 6.3e-29 100.1 0.0 1.2 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain Lipase_GDSL_2 PF13472.6 ELR23240.1 - 4.6e-12 46.7 0.1 7e-12 46.1 0.1 1.3 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 ELR23240.1 - 0.011 15.7 0.0 0.02 14.9 0.0 1.4 1 0 0 1 1 1 0 GDSL-like Lipase/Acylhydrolase PhoLip_ATPase_C PF16212.5 ELR23243.1 - 5e-59 200.1 32.9 5e-59 200.1 32.9 2.8 2 1 0 2 2 2 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 ELR23243.1 - 9e-24 83.0 5.4 2.4e-23 81.6 5.4 1.8 1 0 0 1 1 1 1 Phospholipid-translocating ATPase N-terminal Cation_ATPase PF13246.6 ELR23243.1 - 7.3e-12 45.2 0.1 6.5e-11 42.2 0.1 2.3 2 0 0 2 2 2 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 ELR23243.1 - 3.6e-11 43.8 0.3 4.2e-05 23.9 0.1 3.5 3 0 0 3 3 3 2 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.20 ELR23243.1 - 3.2e-07 30.0 0.0 1.1e-06 28.3 0.0 1.9 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase_3 PF08282.12 ELR23243.1 - 0.0018 18.1 0.1 0.028 14.1 0.0 2.2 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Nop25 PF09805.9 ELR23243.1 - 2.2 8.8 8.9 0.13 12.8 2.3 2.1 2 0 0 2 2 2 0 Nucleolar protein 12 (25kDa) Methyltransf_31 PF13847.6 ELR23244.1 - 7.6e-12 45.3 0.0 9.6e-12 44.9 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 ELR23244.1 - 5.7e-11 42.2 0.0 4.5e-10 39.3 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase small domain PrmA PF06325.13 ELR23244.1 - 1.2e-09 38.1 0.0 1.5e-09 37.7 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_25 PF13649.6 ELR23244.1 - 4.6e-09 36.9 0.0 7.7e-09 36.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ELR23244.1 - 1.5e-06 28.8 0.0 2.6e-06 28.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_10 PF05971.12 ELR23244.1 - 1.8e-05 24.2 0.0 2.6e-05 23.7 0.0 1.1 1 0 0 1 1 1 1 RNA methyltransferase Methyltransf_23 PF13489.6 ELR23244.1 - 2.1e-05 24.5 0.0 3.9e-05 23.6 0.0 1.4 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 ELR23244.1 - 4.6e-05 24.0 0.0 7.6e-05 23.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Cons_hypoth95 PF03602.15 ELR23244.1 - 5.6e-05 22.9 0.0 7.5e-05 22.4 0.0 1.1 1 0 0 1 1 1 1 Conserved hypothetical protein 95 Methyltransf_32 PF13679.6 ELR23244.1 - 0.00023 21.2 0.0 0.00032 20.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain UPF0020 PF01170.18 ELR23244.1 - 0.0016 18.1 0.0 0.0031 17.2 0.0 1.4 1 0 0 1 1 1 1 Putative RNA methylase family UPF0020 Methyltrans_SAM PF10672.9 ELR23244.1 - 0.011 15.0 0.0 0.014 14.6 0.0 1.1 1 0 0 1 1 1 0 S-adenosylmethionine-dependent methyltransferase Methyltransf_9 PF08003.11 ELR23244.1 - 0.049 12.5 0.0 0.072 12.0 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1698) Methyltransf_15 PF09445.10 ELR23244.1 - 0.06 12.9 0.0 0.091 12.3 0.0 1.2 1 0 0 1 1 1 0 RNA cap guanine-N2 methyltransferase PCMT PF01135.19 ELR23244.1 - 0.11 12.2 0.0 0.15 11.8 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) RrnaAD PF00398.20 ELR23244.1 - 0.24 10.5 0.0 0.32 10.0 0.0 1.2 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase PIG-L PF02585.17 ELR23246.1 - 0.1 13.2 0.0 0.18 12.4 0.0 1.4 1 0 0 1 1 1 0 GlcNAc-PI de-N-acetylase CLU PF13236.6 ELR23248.1 - 1.4e-61 208.1 0.0 3.1e-61 207.0 0.0 1.6 1 0 0 1 1 1 1 Clustered mitochondria LRR_4 PF12799.7 ELR23248.1 - 2.4e-11 43.7 37.1 0.0017 18.7 1.3 8.7 9 0 0 9 9 9 5 Leucine Rich repeats (2 copies) eIF3_p135 PF12807.7 ELR23248.1 - 1.7e-09 38.0 0.1 1.7e-09 38.0 0.1 3.8 4 0 0 4 4 4 1 Translation initiation factor eIF3 subunit 135 LRR_6 PF13516.6 ELR23248.1 - 0.0081 16.1 35.2 1.4 9.1 0.4 10.6 11 0 0 11 11 11 4 Leucine Rich repeat PGAP1 PF07819.13 ELR23249.1 - 7.6e-46 156.7 0.0 1.2e-45 156.1 0.0 1.3 1 0 0 1 1 1 1 PGAP1-like protein Hydrolase_4 PF12146.8 ELR23249.1 - 2.3e-05 23.8 1.1 0.00014 21.2 1.1 2.0 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 ELR23249.1 - 7.1e-05 23.5 12.9 0.00035 21.2 2.4 3.9 2 2 0 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 ELR23249.1 - 7.5e-05 22.5 0.0 0.00016 21.4 0.0 1.5 1 0 0 1 1 1 1 alpha/beta hydrolase fold DUF676 PF05057.14 ELR23249.1 - 0.0016 18.0 0.0 0.0033 17.0 0.0 1.4 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Palm_thioest PF02089.15 ELR23249.1 - 0.016 15.1 0.0 0.025 14.4 0.0 1.3 1 0 0 1 1 1 0 Palmitoyl protein thioesterase Lipase_3 PF01764.25 ELR23249.1 - 0.029 14.3 0.1 0.083 12.8 0.0 1.7 2 0 0 2 2 2 0 Lipase (class 3) LCAT PF02450.15 ELR23249.1 - 0.067 12.3 0.0 0.1 11.7 0.0 1.2 1 0 0 1 1 1 0 Lecithin:cholesterol acyltransferase Abhydrolase_9 PF10081.9 ELR23249.1 - 0.12 11.4 0.0 0.32 10.0 0.0 1.6 2 0 0 2 2 2 0 Alpha/beta-hydrolase family NAD_binding_2 PF03446.15 ELR23250.1 - 1.8e-50 171.2 1.7 2.5e-50 170.7 1.7 1.2 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.6 ELR23250.1 - 2.3e-34 118.2 0.1 9.1e-34 116.3 0.0 1.9 2 0 0 2 2 2 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase 2-Hacid_dh_C PF02826.19 ELR23250.1 - 0.00011 21.6 0.1 0.00018 20.9 0.1 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 3HCDH_N PF02737.18 ELR23250.1 - 0.00021 21.3 0.0 0.00039 20.3 0.0 1.5 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain F420_oxidored PF03807.17 ELR23250.1 - 0.00055 20.5 0.0 0.0013 19.3 0.0 1.6 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent IlvN PF07991.12 ELR23250.1 - 0.0023 17.5 0.3 0.004 16.7 0.3 1.3 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain ApbA PF02558.16 ELR23250.1 - 0.021 14.5 0.0 0.033 13.8 0.0 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA TrkA_N PF02254.18 ELR23250.1 - 0.023 15.0 0.0 0.041 14.2 0.0 1.4 1 0 0 1 1 1 0 TrkA-N domain AFOR_N PF02730.15 ELR23250.1 - 0.045 13.6 1.8 0.13 12.1 0.2 2.1 2 0 0 2 2 2 0 Aldehyde ferredoxin oxidoreductase, N-terminal domain UDPG_MGDP_dh_N PF03721.14 ELR23250.1 - 0.048 13.2 0.2 0.99 8.9 0.1 2.2 1 1 0 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Sacchrp_dh_NADP PF03435.18 ELR23250.1 - 0.05 13.9 0.0 0.84 9.9 0.0 2.1 1 1 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain ATP-synt_S1 PF05827.12 ELR23251.1 - 5.9e-05 22.9 0.0 0.00011 22.0 0.0 1.3 1 0 0 1 1 1 1 Vacuolar ATP synthase subunit S1 (ATP6S1) Pkinase_Tyr PF07714.17 ELR23252.1 - 6.1e-58 196.1 0.0 1.6e-57 194.7 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.25 ELR23252.1 - 4.3e-52 177.1 0.2 8.4e-52 176.1 0.0 1.6 2 0 0 2 2 2 1 Protein kinase domain SH2 PF00017.24 ELR23252.1 - 8.9e-06 25.7 0.0 2e-05 24.6 0.0 1.6 1 0 0 1 1 1 1 SH2 domain APH PF01636.23 ELR23252.1 - 0.00072 19.6 0.1 0.053 13.4 0.1 2.4 1 1 0 2 2 2 1 Phosphotransferase enzyme family RNA_pol_Rpc4 PF05132.14 ELR23252.1 - 6.7 7.1 14.7 11 6.4 14.7 1.3 1 0 0 1 1 1 0 RNA polymerase III RPC4 RRXRR PF14239.6 ELR23253.1 - 0.1 12.5 4.5 0.16 11.8 4.5 1.2 1 0 0 1 1 1 0 RRXRR protein NARP1 PF12569.8 ELR23253.1 - 0.68 8.8 6.9 0.95 8.3 6.9 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 Birna_VP2 PF01766.17 ELR23254.1 - 0.13 11.2 0.0 0.16 10.9 0.0 1.1 1 0 0 1 1 1 0 Birnavirus VP2 protein Ependymin PF00811.18 ELR23256.1 - 0.00011 22.5 0.1 0.0002 21.6 0.1 1.4 1 1 0 1 1 1 1 Ependymin Arf PF00025.21 ELR23257.1 - 1.3e-47 161.5 0.0 2.2e-47 160.8 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 ELR23257.1 - 1.3e-08 35.0 0.1 3.3e-08 33.8 0.0 1.7 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase F-box-like PF12937.7 ELR23257.1 - 1.7e-08 34.2 0.5 3.1e-08 33.4 0.5 1.4 1 0 0 1 1 1 1 F-box-like G-alpha PF00503.20 ELR23257.1 - 1.2e-07 31.3 0.0 0.014 14.6 0.1 2.4 1 1 1 2 2 2 2 G-protein alpha subunit Ras PF00071.22 ELR23257.1 - 5.8e-06 26.0 0.0 1.1e-05 25.1 0.0 1.4 1 0 0 1 1 1 1 Ras family SRPRB PF09439.10 ELR23257.1 - 7.3e-06 25.5 0.0 1.5e-05 24.5 0.0 1.5 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit F-box PF00646.33 ELR23257.1 - 3.7e-05 23.5 0.3 7.4e-05 22.5 0.3 1.4 1 0 0 1 1 1 1 F-box domain Gtr1_RagA PF04670.12 ELR23257.1 - 3.7e-05 23.2 0.0 0.00016 21.1 0.0 1.8 2 0 0 2 2 2 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 ELR23257.1 - 0.0016 18.5 0.0 0.0041 17.2 0.0 1.7 2 0 0 2 2 2 1 50S ribosome-binding GTPase VKG_Carbox PF05090.14 ELR23258.1 - 5.6e-06 25.5 7.9 9.1e-06 24.8 7.9 1.3 1 0 0 1 1 1 1 Vitamin K-dependent gamma-carboxylase Glyco_transf_8 PF01501.20 ELR23259.1 - 8.5e-22 77.9 0.0 1.5e-21 77.1 0.0 1.4 1 1 0 1 1 1 1 Glycosyl transferase family 8 F-box-like PF12937.7 ELR23260.1 - 8.9e-08 31.9 0.2 1.8e-07 31.0 0.2 1.5 1 0 0 1 1 1 1 F-box-like Elongin_A PF06881.11 ELR23260.1 - 0.0014 19.1 1.7 0.004 17.7 0.1 2.4 2 1 0 2 2 2 1 RNA polymerase II transcription factor SIII (Elongin) subunit A F-box PF00646.33 ELR23260.1 - 0.0041 17.0 0.1 0.0078 16.1 0.1 1.4 1 0 0 1 1 1 1 F-box domain Ribosomal_60s PF00428.19 ELR23260.1 - 0.0089 16.6 2.0 0.022 15.3 2.0 1.7 1 0 0 1 1 1 1 60s Acidic ribosomal protein Cu-oxidase_2 PF07731.14 ELR23261.1 - 3.1e-21 75.6 0.5 3.1e-21 75.6 0.5 2.0 2 0 0 2 2 2 1 Multicopper oxidase Cu-oxidase_3 PF07732.15 ELR23261.1 - 2e-12 47.2 0.6 1.8e-08 34.4 0.2 3.0 2 1 1 3 3 3 2 Multicopper oxidase Cu-oxidase PF00394.22 ELR23261.1 - 0.012 15.8 0.0 0.023 14.8 0.0 1.4 1 0 0 1 1 1 0 Multicopper oxidase Pkinase_Tyr PF07714.17 ELR23262.1 - 7.8e-46 156.5 0.0 1.4e-45 155.6 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ELR23262.1 - 7.5e-39 133.7 0.0 7.5e-39 133.7 0.0 1.7 2 0 0 2 2 1 1 Protein kinase domain COR PF16095.5 ELR23262.1 - 1.6e-38 132.4 0.0 3.3e-38 131.5 0.0 1.5 1 0 0 1 1 1 1 C-terminal of Roc, COR, domain Roc PF08477.13 ELR23262.1 - 3.1e-24 85.5 1.4 2.5e-19 69.6 0.1 2.7 1 1 1 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase LRR_8 PF13855.6 ELR23262.1 - 1.7e-17 62.9 6.4 9.1e-11 41.4 0.5 3.7 2 1 0 3 3 3 2 Leucine rich repeat LRR_4 PF12799.7 ELR23262.1 - 7.9e-14 51.6 9.8 2.2e-06 27.9 0.9 5.0 3 1 1 4 4 4 3 Leucine Rich repeats (2 copies) Ras PF00071.22 ELR23262.1 - 6.8e-10 38.8 2.9 4.3e-09 36.2 1.3 2.5 2 1 0 2 2 1 1 Ras family LRR_6 PF13516.6 ELR23262.1 - 3.2e-06 26.8 6.9 0.00088 19.1 0.2 5.1 5 0 0 5 5 5 1 Leucine Rich repeat LRR_9 PF14580.6 ELR23262.1 - 0.00014 21.4 2.1 0.00041 19.9 2.0 1.8 1 1 0 1 1 1 1 Leucine-rich repeat WD40 PF00400.32 ELR23262.1 - 0.00046 20.9 14.1 0.0058 17.5 1.9 5.5 5 1 0 5 5 5 1 WD domain, G-beta repeat MMR_HSR1 PF01926.23 ELR23262.1 - 0.0033 17.5 0.0 0.012 15.7 0.0 2.0 1 0 0 1 1 1 1 50S ribosome-binding GTPase LRR_1 PF00560.33 ELR23262.1 - 0.035 14.6 10.2 40 5.3 0.1 6.4 6 0 0 6 6 5 0 Leucine Rich Repeat Septin PF00735.18 ELR23262.1 - 0.037 13.3 0.0 0.037 13.3 0.0 1.7 2 0 0 2 2 1 0 Septin Arf PF00025.21 ELR23262.1 - 0.063 12.7 1.1 3.1 7.2 0.4 2.6 1 1 1 2 2 2 0 ADP-ribosylation factor family CAF-1_p150 PF11600.8 ELR23262.1 - 0.18 11.5 39.4 0.38 10.4 39.4 1.4 1 0 0 1 1 1 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal GTP_EFTU PF00009.27 ELR23262.1 - 0.42 10.1 0.0 0.42 10.1 0.0 2.3 3 0 0 3 3 2 0 Elongation factor Tu GTP binding domain CDC45 PF02724.14 ELR23262.1 - 7.6 4.7 15.7 11 4.1 15.7 1.1 1 0 0 1 1 1 0 CDC45-like protein PP2C PF00481.21 ELR23263.1 - 9.8e-37 127.0 0.0 9.8e-37 127.0 0.0 2.0 2 1 0 2 2 2 1 Protein phosphatase 2C Hamartin PF04388.12 ELR23263.1 - 3 6.4 17.3 4.1 6.0 17.3 1.1 1 0 0 1 1 1 0 Hamartin protein LRR_8 PF13855.6 ELR23264.1 - 6.2e-72 237.3 59.3 1.3e-10 40.8 0.2 10.2 6 2 4 10 10 10 10 Leucine rich repeat LRR_4 PF12799.7 ELR23264.1 - 1.8e-54 180.7 73.2 4e-07 30.2 0.1 13.0 9 4 1 12 12 12 12 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 ELR23264.1 - 7.3e-17 61.4 27.6 0.0015 18.0 1.1 7.1 2 1 5 7 7 7 7 Leucine-rich repeat LRR_1 PF00560.33 ELR23264.1 - 2.2e-15 54.8 63.6 1.2 9.9 0.2 18.9 20 4 1 21 21 19 6 Leucine Rich Repeat PP2C PF00481.21 ELR23264.1 - 3.6e-05 23.5 0.9 0.00058 19.6 0.2 2.3 2 0 0 2 2 2 1 Protein phosphatase 2C LRR_6 PF13516.6 ELR23264.1 - 0.0033 17.4 72.7 3.9 7.8 0.1 17.6 19 0 0 19 19 19 1 Leucine Rich repeat DUF2322 PF10084.9 ELR23264.1 - 0.0097 15.9 0.0 9.5 6.3 0.0 4.2 3 0 0 3 3 3 1 Uncharacterized protein conserved in bacteria (DUF2322) RsmF_methylt_CI PF17126.5 ELR23264.1 - 0.026 14.6 0.3 24 5.1 0.0 5.0 5 1 0 5 5 5 0 RsmF rRNA methyltransferase first C-terminal domain LRR_2 PF07723.13 ELR23264.1 - 0.029 15.1 3.9 1.1e+02 3.7 0.0 6.5 7 0 0 7 7 6 0 Leucine Rich Repeat Telomere_res PF16684.5 ELR23264.1 - 0.13 11.7 0.0 0.27 10.7 0.0 1.5 1 0 0 1 1 1 0 Telomere resolvase F-box-like_2 PF13013.6 ELR23264.1 - 0.17 11.9 1.6 0.29 11.1 0.3 2.1 2 0 0 2 2 2 0 F-box-like domain AA_permease_2 PF13520.6 ELR23265.1 - 1.2e-30 106.8 31.5 1e-24 87.2 19.9 3.0 1 1 2 3 3 3 3 Amino acid permease AA_permease PF00324.21 ELR23265.1 - 6.1e-19 68.0 27.7 7.8e-15 54.4 16.2 2.8 2 1 1 3 3 3 2 Amino acid permease FAD_binding_3 PF01494.19 ELR23266.1 - 0.0024 17.2 0.1 2.2 7.5 0.0 2.6 3 0 0 3 3 3 2 FAD binding domain Thi4 PF01946.17 ELR23266.1 - 0.024 13.9 0.1 0.072 12.3 0.0 1.7 2 0 0 2 2 2 0 Thi4 family Lycopene_cycl PF05834.12 ELR23266.1 - 0.056 12.5 0.3 0.13 11.3 0.3 1.8 1 1 0 1 1 1 0 Lycopene cyclase protein Y_phosphatase PF00102.27 ELR23267.1 - 8.7e-69 231.7 0.0 1.1e-68 231.4 0.0 1.1 1 0 0 1 1 1 1 Protein-tyrosine phosphatase DSPc PF00782.20 ELR23267.1 - 0.0011 18.8 0.0 0.003 17.4 0.0 1.8 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 ELR23267.1 - 0.026 14.5 0.0 0.052 13.5 0.0 1.4 1 0 0 1 1 1 0 Tyrosine phosphatase family Cep57_MT_bd PF06657.13 ELR23267.1 - 0.059 13.8 0.4 0.15 12.5 0.4 1.6 1 0 0 1 1 1 0 Centrosome microtubule-binding domain of Cep57 Zw10 PF06248.13 ELR23268.1 - 1.7e-51 175.4 0.4 3.8e-30 105.0 0.1 3.2 3 0 0 3 3 3 3 Centromere/kinetochore Zw10 Dsl1_C PF11989.8 ELR23268.1 - 0.0022 17.7 0.1 0.07 12.8 0.0 2.6 3 0 0 3 3 3 1 Retrograde transport protein Dsl1 C terminal COG5 PF10392.9 ELR23268.1 - 0.016 15.4 2.8 0.022 15.0 0.1 2.6 3 0 0 3 3 3 0 Golgi transport complex subunit 5 Vps51 PF08700.11 ELR23268.1 - 0.043 13.9 0.1 0.2 11.8 0.0 2.2 2 0 0 2 2 2 0 Vps51/Vps67 Pur_ac_phosph_N PF16656.5 ELR23269.1 - 8e-12 45.6 0.0 1.9e-11 44.4 0.0 1.6 1 0 0 1 1 1 1 Purple acid Phosphatase, N-terminal domain Rax2 PF12768.7 ELR23269.1 - 0.024 14.1 0.3 0.04 13.4 0.3 1.2 1 0 0 1 1 1 0 Cortical protein marker for cell polarity DUF1218 PF06749.12 ELR23269.1 - 0.056 14.0 2.1 0.11 13.0 1.2 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF1218) CHD5 PF04420.14 ELR23269.1 - 7.6 6.4 8.3 0.43 10.4 2.9 1.6 2 0 0 2 2 2 0 CHD5-like protein Pro-kuma_activ PF09286.11 ELR23270.1 - 2.8e-29 102.2 0.0 3.4e-29 102.0 0.0 1.0 1 0 0 1 1 1 1 Pro-kumamolisin, activation domain ArdA PF07275.11 ELR23270.1 - 0.074 13.6 0.0 0.076 13.6 0.0 1.2 1 0 0 1 1 1 0 Antirestriction protein (ArdA) Imm75 PF15660.6 ELR23270.1 - 0.088 13.1 0.0 0.14 12.4 0.0 1.3 1 0 0 1 1 1 0 Putative Immunity protein 75 Tau95_N PF17682.1 ELR23270.1 - 0.1 12.8 0.0 0.12 12.5 0.0 1.2 1 0 0 1 1 1 0 Tau95 Triple barrel domain Acetyltransf_1 PF00583.25 ELR23271.1 - 1.2e-09 38.5 0.0 1.4e-09 38.2 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 ELR23271.1 - 1.3e-06 28.7 0.0 1.6e-06 28.4 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 ELR23271.1 - 6e-06 26.2 0.0 7.5e-06 25.9 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 ELR23271.1 - 1.6e-05 24.8 0.0 2.1e-05 24.4 0.0 1.2 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_9 PF13527.7 ELR23271.1 - 4.8e-05 23.4 0.0 6.4e-05 23.0 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.7 ELR23271.1 - 0.00031 21.4 0.0 0.00038 21.1 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain UBA_6 PF18039.1 ELR23271.1 - 0.11 12.5 0.0 0.21 11.5 0.0 1.6 1 1 0 1 1 1 0 UBA-like domain STAS_2 PF13466.6 ELR23272.1 - 0.022 15.1 0.5 0.044 14.1 0.5 1.5 1 0 0 1 1 1 0 STAS domain G-alpha PF00503.20 ELR23274.1 - 1.6e-113 379.5 0.7 1.8e-113 379.3 0.7 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 ELR23274.1 - 8.2e-10 38.4 0.7 6.4e-07 29.0 0.1 2.4 2 0 0 2 2 2 2 ADP-ribosylation factor family Gtr1_RagA PF04670.12 ELR23274.1 - 0.0011 18.4 0.2 0.2 11.0 0.0 2.3 2 0 0 2 2 2 2 Gtr1/RagA G protein conserved region RE_CfrBI PF09516.10 ELR23274.1 - 0.0072 15.8 0.1 0.013 14.9 0.1 1.4 1 0 0 1 1 1 1 CfrBI restriction endonuclease FtsK_SpoIIIE PF01580.18 ELR23274.1 - 0.082 12.2 0.0 1.8 7.9 0.0 2.1 2 0 0 2 2 2 0 FtsK/SpoIIIE family AAA_24 PF13479.6 ELR23274.1 - 0.098 12.4 0.0 0.16 11.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain Roc PF08477.13 ELR23274.1 - 0.14 12.4 1.5 2.7 8.2 0.0 3.1 2 1 1 3 3 3 0 Ras of Complex, Roc, domain of DAPkinase SpoU_methylase PF00588.19 ELR23275.1 - 1.6e-17 64.0 0.0 7.3e-14 52.1 0.0 2.7 1 1 0 1 1 1 1 SpoU rRNA Methylase family Methyltrn_RNA_4 PF09936.9 ELR23275.1 - 0.059 13.2 0.0 1.8 8.4 0.0 2.5 1 1 0 2 2 2 0 SAM-dependent RNA methyltransferase PX PF00787.24 ELR23277.1 - 1.1e-11 44.7 0.1 3e-11 43.3 0.1 1.7 1 0 0 1 1 1 1 PX domain Cwf_Cwc_15 PF04889.12 ELR23277.1 - 0.021 14.6 3.5 0.037 13.7 3.5 1.4 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Tox-REase-2 PF15646.6 ELR23277.1 - 0.089 13.0 0.1 0.2 11.8 0.1 1.5 1 0 0 1 1 1 0 Restriction endonuclease fold toxin 2 Rrn6 PF10214.9 ELR23277.1 - 1.2 7.5 6.1 1.5 7.2 6.1 1.3 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor Tweety PF04906.13 ELR23278.1 - 4.6e-17 61.8 10.2 1.5e-11 43.6 0.3 4.3 4 1 1 5 5 5 3 Tweety TMEM52 PF14979.6 ELR23278.1 - 0.0007 19.5 0.2 0.026 14.4 0.0 3.3 3 0 0 3 3 3 1 Transmembrane 52 DUF1871 PF08958.10 ELR23278.1 - 0.12 12.7 0.0 0.4 11.0 0.0 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF1871) BLOC1_2 PF10046.9 ELR23278.1 - 0.15 12.4 0.8 3.5 8.0 0.1 3.1 3 0 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF4131 PF13567.6 ELR23278.1 - 0.18 11.5 13.1 3.1 7.4 5.5 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4131) SUR7 PF06687.12 ELR23278.1 - 0.37 10.4 11.6 7.9 6.0 0.0 3.7 2 1 0 3 3 3 0 SUR7/PalI family EphA2_TM PF14575.6 ELR23278.1 - 0.75 10.7 2.7 19 6.2 1.4 3.1 2 1 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain DUF1565 PF07602.11 ELR23279.1 - 0.00033 20.1 6.0 0.0057 16.0 6.0 2.8 1 1 0 1 1 1 1 Protein of unknown function (DUF1565) Chlam_PMP PF02415.17 ELR23279.1 - 0.0039 17.6 7.2 0.24 11.9 1.2 3.9 3 0 0 3 3 3 2 Chlamydia polymorphic membrane protein (Chlamydia_PMP) repeat DAO PF01266.24 ELR23280.1 - 7.6e-32 111.2 0.1 8.7e-32 111.1 0.1 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 ELR23280.1 - 0.0027 17.0 0.0 0.0065 15.8 0.0 1.6 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase CitMHS PF03600.16 ELR23281.1 - 1e-43 149.6 25.9 1e-43 149.6 25.9 2.3 1 1 1 2 2 2 2 Citrate transporter Na_sulph_symp PF00939.19 ELR23281.1 - 7.3e-11 41.8 36.4 2e-09 37.0 13.8 2.2 2 0 0 2 2 2 2 Sodium:sulfate symporter transmembrane region ArsB PF02040.15 ELR23281.1 - 2.9e-09 36.8 30.6 6.9e-05 22.3 9.8 3.6 2 2 1 3 3 3 3 Arsenical pump membrane protein WD40 PF00400.32 ELR23282.1 - 2.3e-16 59.8 12.5 8.4e-06 26.4 0.2 4.0 4 0 0 4 4 4 3 WD domain, G-beta repeat F-box PF00646.33 ELR23282.1 - 0.0082 16.0 0.0 0.018 14.9 0.0 1.5 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 ELR23282.1 - 0.034 14.0 0.0 0.11 12.5 0.0 1.9 1 0 0 1 1 1 0 F-box-like Pyr_redox_2 PF07992.14 ELR23283.1 - 1.4e-69 234.6 5.3 1.5e-69 234.4 3.7 1.7 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.22 ELR23283.1 - 2.4e-41 140.4 0.2 7.3e-41 138.9 0.2 1.9 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.27 ELR23283.1 - 8.6e-21 74.3 8.3 4.6e-17 62.3 0.4 3.3 3 1 1 4 4 3 2 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 ELR23283.1 - 3.1e-11 43.0 4.0 2.9e-10 39.8 0.3 2.1 2 0 0 2 2 2 1 Glucose inhibited division protein A NAD_binding_8 PF13450.6 ELR23283.1 - 4.1e-11 42.9 2.0 4.5e-06 26.8 0.2 2.5 2 0 0 2 2 2 2 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.6 ELR23283.1 - 1.3e-10 41.0 4.2 4.7e-07 29.4 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 ELR23283.1 - 1.1e-08 34.9 4.0 1.1e-08 34.9 4.0 2.7 2 2 0 2 2 2 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 ELR23283.1 - 3.4e-08 33.0 12.1 7.3e-07 28.6 2.0 4.4 5 0 0 5 5 5 1 FAD binding domain HI0933_like PF03486.14 ELR23283.1 - 2.8e-06 26.3 8.7 3.2e-05 22.8 1.4 3.8 4 0 0 4 4 4 1 HI0933-like protein AlaDh_PNT_C PF01262.21 ELR23283.1 - 5.2e-05 22.6 8.9 0.024 13.9 0.8 2.7 3 0 0 3 3 3 2 Alanine dehydrogenase/PNT, C-terminal domain FAD_binding_3 PF01494.19 ELR23283.1 - 0.0002 20.7 7.1 0.013 14.7 1.4 3.2 3 0 0 3 3 3 1 FAD binding domain K_oxygenase PF13434.6 ELR23283.1 - 0.00026 20.3 0.2 0.026 13.7 0.0 2.6 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) Thi4 PF01946.17 ELR23283.1 - 0.00031 20.1 3.5 0.0017 17.6 0.1 2.3 2 0 0 2 2 2 1 Thi4 family Lycopene_cycl PF05834.12 ELR23283.1 - 0.00043 19.5 0.3 0.015 14.4 0.0 2.3 2 0 0 2 2 2 1 Lycopene cyclase protein XdhC_C PF13478.6 ELR23283.1 - 0.049 14.1 0.1 22 5.6 0.0 2.9 3 0 0 3 3 3 0 XdhC Rossmann domain NAD_binding_7 PF13241.6 ELR23283.1 - 0.22 12.0 0.9 20 5.7 0.2 2.5 2 0 0 2 2 2 0 Putative NAD(P)-binding DAO PF01266.24 ELR23283.1 - 0.31 10.6 19.4 4.7 6.7 4.0 4.1 2 2 1 4 4 4 0 FAD dependent oxidoreductase Trp_halogenase PF04820.14 ELR23283.1 - 2.5 6.8 4.9 0.57 9.0 0.5 2.0 2 0 0 2 2 2 0 Tryptophan halogenase 3HCDH_N PF02737.18 ELR23283.1 - 6.7 6.6 7.1 0.37 10.7 0.4 2.1 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Ribosomal_L37ae PF01780.19 ELR23284.1 - 4.6e-42 142.0 10.3 5.2e-42 141.8 10.3 1.0 1 0 0 1 1 1 1 Ribosomal L37ae protein family Zn_Tnp_IS1595 PF12760.7 ELR23284.1 - 0.0034 17.3 1.8 0.0054 16.7 1.8 1.3 1 0 0 1 1 1 1 Transposase zinc-ribbon domain Endonuclease_7 PF02945.15 ELR23284.1 - 0.013 15.4 0.2 0.015 15.2 0.2 1.2 1 0 0 1 1 1 0 Recombination endonuclease VII zf-RING_13 PF17977.1 ELR23284.1 - 0.017 15.2 3.3 0.024 14.7 3.3 1.3 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-BED PF02892.15 ELR23284.1 - 0.021 14.9 3.8 1.2 9.2 0.3 2.2 1 1 1 2 2 2 0 BED zinc finger DUF1451 PF07295.11 ELR23284.1 - 0.035 14.1 0.9 0.05 13.6 0.9 1.2 1 0 0 1 1 1 0 Zinc-ribbon containing domain A2L_zn_ribbon PF08792.10 ELR23284.1 - 0.043 13.6 3.0 3.6 7.4 0.7 2.2 2 0 0 2 2 2 0 A2L zinc ribbon domain C1_2 PF03107.16 ELR23284.1 - 0.27 11.6 2.2 1.7 9.0 2.4 1.9 1 1 0 1 1 1 0 C1 domain zf-H2C2_2 PF13465.6 ELR23284.1 - 0.73 10.4 4.3 2.2 8.9 0.7 2.3 1 1 1 2 2 2 0 Zinc-finger double domain HalOD2 PF18547.1 ELR23284.1 - 1 9.3 7.5 0.61 10.0 1.8 2.4 1 1 1 2 2 2 0 Halobacterial output domain 2 Zn_ribbon_SprT PF17283.2 ELR23284.1 - 1.6 8.7 7.1 0.23 11.4 1.8 2.2 3 1 0 3 3 3 0 SprT-like zinc ribbon domain Tfb5 PF06331.12 ELR23285.1 - 1.1e-26 92.6 1.0 1.2e-26 92.5 1.0 1.0 1 0 0 1 1 1 1 Transcription factor TFIIH complex subunit Tfb5 Metallophos PF00149.28 ELR23286.1 - 2.3e-25 90.3 1.7 2.3e-25 90.3 1.7 2.1 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase Pur_ac_phosph_N PF16656.5 ELR23286.1 - 3.3e-22 78.8 2.0 7.6e-22 77.7 2.0 1.6 1 0 0 1 1 1 1 Purple acid Phosphatase, N-terminal domain Metallophos_C PF14008.6 ELR23286.1 - 1.3e-08 35.6 0.3 4e-08 34.0 0.3 2.0 1 0 0 1 1 1 1 Iron/zinc purple acid phosphatase-like protein C EF-hand_6 PF13405.6 ELR23286.1 - 1.5e-07 30.8 0.0 0.00049 19.8 0.0 2.7 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.32 ELR23286.1 - 0.00011 21.5 0.0 0.026 14.1 0.0 2.5 2 0 0 2 2 2 1 EF hand EF-hand_7 PF13499.6 ELR23286.1 - 0.0026 18.2 0.0 0.0077 16.7 0.0 1.8 1 1 1 2 2 2 1 EF-hand domain pair Metallophos_2 PF12850.7 ELR23286.1 - 0.011 16.0 0.0 0.1 12.8 0.0 2.4 2 1 0 2 2 2 0 Calcineurin-like phosphoesterase superfamily domain PhoD_N PF16655.5 ELR23286.1 - 0.012 16.1 0.1 0.032 14.7 0.1 1.8 1 0 0 1 1 1 0 PhoD-like phosphatase, N-terminal domain EF-hand_5 PF13202.6 ELR23286.1 - 0.031 13.8 0.1 0.33 10.5 0.0 2.3 2 0 0 2 2 2 0 EF hand EF-hand_8 PF13833.6 ELR23286.1 - 0.069 13.0 0.0 0.89 9.4 0.0 2.2 2 0 0 2 2 2 0 EF-hand domain pair fn3 PF00041.21 ELR23286.1 - 0.088 13.2 0.7 0.24 11.8 0.7 1.7 1 0 0 1 1 1 0 Fibronectin type III domain 5_nucleotid_C PF02872.18 ELR23287.1 - 3.7e-32 111.7 0.0 7e-32 110.8 0.0 1.4 1 0 0 1 1 1 1 5'-nucleotidase, C-terminal domain Metallophos PF00149.28 ELR23287.1 - 0.00076 20.0 0.0 0.0016 19.0 0.0 1.6 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase WD40 PF00400.32 ELR23288.1 - 1.4e-18 66.9 9.0 1.9e-05 25.3 0.1 5.7 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ELR23288.1 - 0.00068 19.9 0.1 0.54 10.6 0.1 4.1 3 2 0 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ELR23288.1 - 0.053 12.2 0.0 0.09 11.4 0.0 1.6 1 0 0 1 1 1 0 Nucleoporin Nup120/160 MRJP PF03022.16 ELR23288.1 - 0.057 12.8 0.1 1.7 8.0 0.0 2.3 1 1 1 2 2 2 0 Major royal jelly protein MTBP_mid PF14919.6 ELR23288.1 - 0.076 12.2 0.3 0.12 11.5 0.3 1.2 1 0 0 1 1 1 0 MDM2-binding ubiquitin PF00240.23 ELR23289.1 - 1.8e-25 88.5 2.6 4.5e-25 87.2 2.6 1.7 1 1 0 1 1 1 1 Ubiquitin family zf-AN1 PF01428.16 ELR23289.1 - 6.5e-11 42.2 9.0 7.1e-11 42.1 8.0 1.6 1 1 0 1 1 1 1 AN1-like Zinc finger Rad60-SLD PF11976.8 ELR23289.1 - 3.4e-10 39.6 1.3 2e-09 37.1 1.3 2.0 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_5 PF18037.1 ELR23289.1 - 0.0045 17.3 0.1 0.0074 16.6 0.1 1.3 1 0 0 1 1 1 1 Ubiquitin-like domain Rad60-SLD_2 PF13881.6 ELR23289.1 - 0.012 15.7 0.1 0.074 13.2 0.1 2.2 1 1 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_4 PF18036.1 ELR23289.1 - 0.014 15.5 1.0 2 8.5 0.3 2.3 1 1 1 2 2 2 0 Ubiquitin-like domain DUF2407 PF10302.9 ELR23289.1 - 0.027 15.0 0.0 0.031 14.8 0.0 1.4 1 1 0 1 1 1 0 DUF2407 ubiquitin-like domain Ubiquitin_2 PF14560.6 ELR23289.1 - 0.1 13.1 0.5 16 6.0 0.1 2.3 1 1 1 2 2 2 0 Ubiquitin-like domain Dus PF01207.17 ELR23290.1 - 2.2e-60 204.4 0.0 8.6e-41 140.0 0.0 2.1 2 0 0 2 2 2 2 Dihydrouridine synthase (Dus) His_biosynth PF00977.21 ELR23290.1 - 0.00023 20.7 0.0 0.00053 19.5 0.0 1.5 1 0 0 1 1 1 1 Histidine biosynthesis protein SOR_SNZ PF01680.17 ELR23290.1 - 0.059 13.2 0.0 0.1 12.4 0.0 1.3 1 0 0 1 1 1 0 SOR/SNZ family Ribosomal_L29 PF00831.23 ELR23291.1 - 2.2e-19 69.2 3.5 2.2e-19 69.2 3.5 2.2 2 1 0 2 2 2 1 Ribosomal L29 protein Snapin_Pallidin PF14712.6 ELR23291.1 - 0.00045 20.6 3.9 0.00045 20.6 3.9 2.1 1 1 1 2 2 2 1 Snapin/Pallidin FlxA PF14282.6 ELR23291.1 - 0.072 13.1 5.8 0.11 12.4 5.5 1.6 1 1 0 1 1 1 0 FlxA-like protein HTH_ABP1_N PF18107.1 ELR23291.1 - 0.17 11.6 2.0 0.21 11.4 0.3 2.1 1 1 1 2 2 2 0 Fission yeast centromere protein N-terminal domain TolA_bind_tri PF16331.5 ELR23291.1 - 0.6 10.2 5.6 0.28 11.3 0.5 2.3 2 1 0 2 2 2 0 TolA binding protein trimerisation Prefoldin PF02996.17 ELR23291.1 - 0.88 9.5 8.9 0.37 10.7 0.9 2.8 2 1 1 3 3 3 0 Prefoldin subunit MFS_1 PF07690.16 ELR23292.1 - 5.4e-16 58.5 38.7 1.4e-14 53.8 14.1 3.0 1 1 2 3 3 3 3 Major Facilitator Superfamily UNC-93 PF05978.16 ELR23292.1 - 2.9e-13 49.8 10.0 2.9e-13 49.8 10.0 3.7 2 2 0 2 2 2 1 Ion channel regulatory protein UNC-93 MFS_1_like PF12832.7 ELR23292.1 - 7.2e-06 25.1 19.8 0.00023 20.2 9.1 3.2 3 0 0 3 3 3 3 MFS_1 like family DUF5445 PF17520.2 ELR23292.1 - 1.6 8.6 5.4 21 5.1 0.2 3.1 3 0 0 3 3 3 0 Family of unknown function (DUF5445) Cytochrom_C_2 PF01322.20 ELR23293.1 - 0.064 14.1 0.1 0.11 13.4 0.1 1.3 1 0 0 1 1 1 0 Cytochrome C' Ank_2 PF12796.7 ELR23294.1 - 1.5e-37 128.0 0.0 1.3e-12 48.1 0.1 4.7 1 1 3 5 5 5 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ELR23294.1 - 1.2e-31 108.7 0.1 1e-05 26.0 0.0 7.2 3 2 4 7 7 7 7 Ankyrin repeats (many copies) Ank_3 PF13606.6 ELR23294.1 - 2.4e-30 101.1 6.3 0.00092 19.5 0.1 8.8 8 1 1 9 9 9 6 Ankyrin repeat Ank PF00023.30 ELR23294.1 - 4e-26 90.3 14.2 0.0011 19.3 0.0 8.6 8 1 0 8 8 8 7 Ankyrin repeat Ank_5 PF13857.6 ELR23294.1 - 1.7e-23 82.3 2.6 0.00051 20.3 0.0 7.0 5 2 3 8 8 8 4 Ankyrin repeats (many copies) AAA PF00004.29 ELR23296.1 - 5.7e-57 191.8 0.0 2.3e-45 154.2 0.0 2.4 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 ELR23296.1 - 1.5e-07 31.3 0.0 0.0022 17.8 0.0 2.5 2 0 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 ELR23296.1 - 1.6e-07 31.9 0.7 0.012 16.0 0.1 3.8 2 1 0 3 3 3 2 AAA ATPase domain AAA_18 PF13238.6 ELR23296.1 - 9.3e-07 29.5 0.0 0.077 13.5 0.0 2.8 2 0 0 2 2 2 2 AAA domain AAA_lid_3 PF17862.1 ELR23296.1 - 2.2e-06 27.4 4.5 0.02 14.7 0.1 2.7 2 0 0 2 2 2 2 AAA+ lid domain AAA_22 PF13401.6 ELR23296.1 - 7.2e-05 23.1 0.3 0.027 14.8 0.1 3.4 2 2 0 2 2 2 1 AAA domain RNA_helicase PF00910.22 ELR23296.1 - 7.4e-05 23.1 0.0 0.037 14.4 0.0 2.4 2 0 0 2 2 2 1 RNA helicase AAA_33 PF13671.6 ELR23296.1 - 0.0001 22.5 0.1 0.23 11.6 0.0 2.8 3 0 0 3 3 2 2 AAA domain AAA_25 PF13481.6 ELR23296.1 - 0.0026 17.4 0.2 0.03 13.9 0.0 3.0 2 1 0 2 2 2 1 AAA domain AAA_5 PF07728.14 ELR23296.1 - 0.0036 17.3 0.1 0.11 12.5 0.1 3.0 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.21 ELR23296.1 - 0.0068 15.8 0.1 0.093 12.1 0.0 2.3 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI Cytidylate_kin PF02224.18 ELR23296.1 - 0.01 15.6 0.0 5.2 6.7 0.0 2.4 2 0 0 2 2 2 0 Cytidylate kinase TIP49 PF06068.13 ELR23296.1 - 0.013 14.8 0.0 0.064 12.5 0.0 1.9 2 0 0 2 2 2 0 TIP49 P-loop domain IstB_IS21 PF01695.17 ELR23296.1 - 0.013 15.2 0.0 0.06 13.1 0.0 2.0 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA_28 PF13521.6 ELR23296.1 - 0.013 15.7 0.0 0.98 9.6 0.0 2.7 2 0 0 2 2 2 0 AAA domain Vps4_C PF09336.10 ELR23296.1 - 0.015 15.3 0.0 0.041 13.9 0.0 1.7 1 0 0 1 1 1 0 Vps4 C terminal oligomerisation domain AAA_24 PF13479.6 ELR23296.1 - 0.017 14.9 0.0 0.61 9.8 0.0 2.6 3 0 0 3 3 2 0 AAA domain TsaE PF02367.17 ELR23296.1 - 0.023 14.7 0.0 0.96 9.5 0.0 2.5 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Parvo_NS1 PF01057.17 ELR23296.1 - 0.063 12.4 0.0 0.13 11.3 0.0 1.4 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 AAA_2 PF07724.14 ELR23296.1 - 0.098 12.8 0.0 0.36 10.9 0.0 2.0 2 0 0 2 2 1 0 AAA domain (Cdc48 subfamily) AAA_7 PF12775.7 ELR23296.1 - 0.13 11.7 0.0 0.26 10.8 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region Molydop_binding PF01568.21 ELR23296.1 - 0.15 12.1 0.0 1.7 8.7 0.0 2.2 2 0 0 2 2 2 0 Molydopterin dinucleotide binding domain ATPase PF06745.13 ELR23296.1 - 0.21 10.9 0.0 0.36 10.1 0.0 1.3 1 0 0 1 1 1 0 KaiC CENP-B_dimeris PF09026.10 ELR23296.1 - 0.33 11.3 21.8 0.29 11.5 5.7 2.6 2 0 0 2 2 2 0 Centromere protein B dimerisation domain FAM176 PF14851.6 ELR23296.1 - 0.41 10.3 7.7 3.2 7.4 0.2 2.6 3 0 0 3 3 2 0 FAM176 family GCIP PF13324.6 ELR23296.1 - 1.8 8.1 4.3 13 5.3 0.3 2.3 2 0 0 2 2 2 0 Grap2 and cyclin-D-interacting Sigma70_ner PF04546.13 ELR23296.1 - 6.9 6.5 8.2 9.2 6.1 0.5 2.3 2 0 0 2 2 2 0 Sigma-70, non-essential region BUD22 PF09073.10 ELR23296.1 - 7.6 5.8 12.0 1.1 8.6 0.1 2.7 3 0 0 3 3 3 0 BUD22 bZIP_1 PF00170.21 ELR23297.1 - 1.4e-19 69.9 8.6 2.4e-19 69.2 8.6 1.4 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 ELR23297.1 - 4.2e-12 46.0 8.3 7.8e-12 45.1 8.3 1.4 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_Maf PF03131.17 ELR23297.1 - 7.3e-07 29.6 1.8 1.2e-06 28.9 1.8 1.3 1 0 0 1 1 1 1 bZIP Maf transcription factor Spc29 PF17082.5 ELR23297.1 - 0.005 16.7 0.4 0.0084 16.0 0.4 1.3 1 0 0 1 1 1 1 Spindle Pole Component 29 NRBF2 PF08961.10 ELR23297.1 - 0.0056 16.3 2.4 0.013 15.2 2.4 1.5 1 0 0 1 1 1 1 Nuclear receptor-binding factor 2, autophagy regulator RecG_N PF17190.4 ELR23297.1 - 0.016 15.9 0.7 0.04 14.6 0.7 1.6 1 0 0 1 1 1 0 RecG N-terminal helical domain HALZ PF02183.18 ELR23297.1 - 0.024 14.9 0.7 0.05 13.8 0.7 1.5 1 0 0 1 1 1 0 Homeobox associated leucine zipper DivIC PF04977.15 ELR23297.1 - 0.029 14.2 0.4 0.059 13.1 0.4 1.5 1 0 0 1 1 1 0 Septum formation initiator Col_cuticle_N PF01484.17 ELR23297.1 - 0.096 12.8 0.1 0.19 11.8 0.1 1.4 1 0 0 1 1 1 0 Nematode cuticle collagen N-terminal domain HDV_ag PF01517.18 ELR23297.1 - 0.2 11.4 3.3 0.17 11.6 1.3 1.8 2 0 0 2 2 2 0 Hepatitis delta virus delta antigen ZapB PF06005.12 ELR23297.1 - 2.7 8.5 7.6 0.19 12.2 1.4 2.0 1 1 1 2 2 2 0 Cell division protein ZapB Glyco_hydro_38N PF01074.22 ELR23298.1 - 9.7e-88 294.3 1.0 1.5e-87 293.6 1.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 N-terminal domain Glyco_hydro_38C PF07748.13 ELR23298.1 - 1.2e-22 81.0 0.0 2.4e-22 80.1 0.0 1.5 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 C-terminal domain Alpha-mann_mid PF09261.11 ELR23298.1 - 2.4e-19 69.3 0.5 7.9e-19 67.6 0.5 2.0 1 0 0 1 1 1 1 Alpha mannosidase middle domain CDC45 PF02724.14 ELR23298.1 - 0.0034 15.7 16.1 0.0072 14.7 16.1 1.5 1 0 0 1 1 1 1 CDC45-like protein Presenilin PF01080.17 ELR23298.1 - 0.0042 15.9 10.4 0.0068 15.2 10.4 1.3 1 0 0 1 1 1 1 Presenilin SAPS PF04499.15 ELR23298.1 - 0.048 12.4 9.2 0.077 11.8 9.2 1.3 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein GREB1 PF15782.5 ELR23298.1 - 0.15 9.2 5.1 0.19 8.8 5.1 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer ALMT PF11744.8 ELR23298.1 - 0.18 10.6 13.1 0.29 9.9 13.1 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter MDM1 PF15501.6 ELR23298.1 - 0.21 10.7 27.3 0.24 10.5 25.4 1.8 2 0 0 2 2 2 0 Nuclear protein MDM1 Rrn6 PF10214.9 ELR23298.1 - 0.41 9.1 12.4 14 4.0 0.0 2.3 2 0 0 2 2 2 0 RNA polymerase I-specific transcription-initiation factor Sec62 PF03839.16 ELR23298.1 - 0.77 9.2 12.7 1.6 8.2 12.7 1.6 1 0 0 1 1 1 0 Translocation protein Sec62 DUF966 PF06136.13 ELR23298.1 - 0.79 9.4 14.8 1.5 8.5 14.8 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF966) RR_TM4-6 PF06459.12 ELR23298.1 - 0.86 9.4 24.4 1.6 8.5 24.4 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 VIT1 PF01988.19 ELR23298.1 - 1.7 8.5 6.3 4.6 7.1 6.3 1.7 1 0 0 1 1 1 0 VIT family Zip PF02535.22 ELR23298.1 - 1.8 7.7 4.6 3.5 6.7 4.6 1.5 1 0 0 1 1 1 0 ZIP Zinc transporter Hid1 PF12722.7 ELR23298.1 - 4.8 5.2 16.4 7.6 4.5 16.4 1.2 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein DUF2828 PF11443.8 ELR23298.1 - 5.8 4.9 14.7 9.5 4.2 14.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) FtsX PF02687.21 ELR23299.1 - 9e-16 58.1 19.5 8.5e-10 39.0 3.1 6.4 6 1 0 6 6 6 2 FtsX-like permease family DUF1610 PF07754.11 ELR23300.1 - 0.019 14.9 0.4 0.73 9.9 0.2 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF1610) FAM176 PF14851.6 ELR23301.1 - 7.6e-05 22.4 11.1 0.045 13.4 0.3 2.2 2 0 0 2 2 2 2 FAM176 family RXT2_N PF08595.11 ELR23301.1 - 0.0001 22.3 10.1 0.0054 16.8 1.0 2.2 2 0 0 2 2 2 2 RXT2-like, N-terminal SpoIIIAH PF12685.7 ELR23301.1 - 0.0016 18.3 2.0 0.29 11.0 0.2 2.1 2 0 0 2 2 2 1 SpoIIIAH-like protein BCS1_N PF08740.11 ELR23301.1 - 0.0057 16.7 3.4 0.072 13.1 0.6 2.5 2 1 0 2 2 2 1 BCS1 N terminal AP3D1 PF06375.11 ELR23301.1 - 0.01 16.1 5.7 0.01 16.1 5.7 2.1 2 0 0 2 2 2 0 AP-3 complex subunit delta-1 Tim54 PF11711.8 ELR23301.1 - 0.01 14.7 4.6 0.14 10.9 1.4 2.2 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 BSP_II PF05432.11 ELR23301.1 - 0.012 15.3 22.6 0.075 12.7 5.9 2.1 2 0 0 2 2 2 0 Bone sialoprotein II (BSP-II) DUF4611 PF15387.6 ELR23301.1 - 0.014 15.6 17.0 0.32 11.3 3.8 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4611) Tub_N PF16322.5 ELR23301.1 - 0.016 15.6 7.4 0.098 13.1 0.4 2.2 2 0 0 2 2 2 0 Tubby N-terminal Myc_N PF01056.18 ELR23301.1 - 0.034 14.1 13.0 0.28 11.0 2.4 2.2 2 0 0 2 2 2 0 Myc amino-terminal region RNA_pol_Rpc4 PF05132.14 ELR23301.1 - 0.036 14.5 4.6 0.57 10.6 0.8 2.2 2 0 0 2 2 2 0 RNA polymerase III RPC4 DDHD PF02862.17 ELR23301.1 - 0.037 14.2 0.1 0.87 9.7 0.0 2.1 2 0 0 2 2 2 0 DDHD domain RPA43_OB PF17875.1 ELR23301.1 - 0.039 14.6 7.0 0.69 10.5 2.3 2.3 2 0 0 2 2 2 0 RPA43 OB domain in RNA Pol I Pox_Ag35 PF03286.14 ELR23301.1 - 0.04 13.7 17.4 0.21 11.4 6.0 2.2 2 0 0 2 2 2 0 Pox virus Ag35 surface protein NOA36 PF06524.12 ELR23301.1 - 0.043 13.1 18.8 0.26 10.6 7.1 2.1 2 0 0 2 2 2 0 NOA36 protein DUF913 PF06025.12 ELR23301.1 - 0.057 12.4 3.7 0.74 8.7 0.6 2.1 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) CPSF100_C PF13299.6 ELR23301.1 - 0.092 12.9 7.2 0.59 10.3 2.2 2.2 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal DUF3506 PF12014.8 ELR23301.1 - 0.12 12.3 2.6 0.13 12.2 0.2 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF3506) PPP4R2 PF09184.11 ELR23301.1 - 0.16 11.6 16.6 0.92 9.0 3.8 2.1 2 0 0 2 2 2 0 PPP4R2 Connexin PF00029.19 ELR23301.1 - 0.23 11.2 2.8 1.7 8.4 1.3 2.1 2 0 0 2 2 2 0 Connexin SDA1 PF05285.12 ELR23301.1 - 0.24 10.8 16.6 1.3 8.3 3.9 2.1 2 0 0 2 2 2 0 SDA1 Slu7 PF11708.8 ELR23301.1 - 0.28 10.9 15.2 0.27 10.9 5.2 2.1 2 0 0 2 2 2 0 Pre-mRNA splicing Prp18-interacting factor DUF4820 PF16091.5 ELR23301.1 - 0.28 10.5 8.9 0.22 10.9 1.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4820) SpoIIP PF07454.11 ELR23301.1 - 0.31 10.4 5.4 0.66 9.4 0.9 2.1 2 0 0 2 2 2 0 Stage II sporulation protein P (SpoIIP) TLP-20 PF06088.11 ELR23301.1 - 0.37 10.6 9.6 0.56 10.1 0.4 2.1 2 0 0 2 2 2 0 Nucleopolyhedrovirus telokin-like protein-20 (TLP20) CENP-B_dimeris PF09026.10 ELR23301.1 - 0.45 10.9 20.5 0.25 11.8 5.9 2.8 3 0 0 3 3 2 0 Centromere protein B dimerisation domain Radial_spoke PF04712.12 ELR23301.1 - 0.45 9.4 12.8 0.3 10.0 1.1 2.1 2 0 0 2 2 2 0 Radial spokehead-like protein Vfa1 PF08432.10 ELR23301.1 - 0.66 10.3 15.8 1.8 8.8 7.6 2.2 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 Eapp_C PF10238.9 ELR23301.1 - 0.69 10.0 8.3 1.6 8.8 3.1 2.3 2 0 0 2 2 2 0 E2F-associated phosphoprotein DUF3464 PF11947.8 ELR23301.1 - 0.7 9.6 11.6 0.35 10.6 5.7 2.2 2 0 0 2 2 2 0 Photosynthesis affected mutant 68 ORC_WH_C PF18137.1 ELR23301.1 - 0.94 9.5 11.8 7.6 6.6 0.2 2.3 2 0 0 2 2 2 0 Origin recognition complex winged helix C-terminal Treacle PF03546.14 ELR23301.1 - 0.96 8.2 11.5 2.1 7.1 0.1 2.1 2 0 0 2 2 2 0 Treacher Collins syndrome protein Treacle Ribosomal_60s PF00428.19 ELR23301.1 - 1.2 9.8 20.5 3.2 8.4 4.2 2.6 2 0 0 2 2 2 0 60s Acidic ribosomal protein BUD22 PF09073.10 ELR23301.1 - 1.3 8.3 20.4 2.7 7.2 5.0 2.1 2 0 0 2 2 2 0 BUD22 Afi1 PF07792.12 ELR23301.1 - 1.3 9.5 10.9 2.9 8.4 2.8 2.3 2 0 0 2 2 2 0 Docking domain of Afi1 for Arf3 in vesicle trafficking DUF4746 PF15928.5 ELR23301.1 - 1.3 8.4 16.9 2.5 7.4 3.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4746) CDC45 PF02724.14 ELR23301.1 - 1.5 7.0 15.9 0.33 9.2 1.7 2.1 2 0 0 2 2 2 0 CDC45-like protein Mlh1_C PF16413.5 ELR23301.1 - 1.7 7.9 7.3 1.7 7.9 1.0 2.1 2 0 0 2 2 2 0 DNA mismatch repair protein Mlh1 C-terminus Cwf_Cwc_15 PF04889.12 ELR23301.1 - 1.8 8.2 21.4 2.2 8.0 6.8 2.3 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein CDC27 PF09507.10 ELR23301.1 - 1.9 7.8 16.0 1.3 8.4 5.2 2.2 2 0 0 2 2 2 0 DNA polymerase subunit Cdc27 Sigma70_ner PF04546.13 ELR23301.1 - 1.9 8.3 16.1 2.5 7.9 5.1 2.2 2 0 0 2 2 2 0 Sigma-70, non-essential region DUF3449 PF11931.8 ELR23301.1 - 1.9 8.2 9.6 4.4 7.0 3.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF3449) Nop14 PF04147.12 ELR23301.1 - 2.8 6.0 18.8 1.8 6.7 5.5 2.0 2 0 0 2 2 2 0 Nop14-like family Nop53 PF07767.11 ELR23301.1 - 3.5 6.9 20.3 3 7.2 3.6 2.2 2 0 0 2 2 2 0 Nop53 (60S ribosomal biogenesis) PBP1_TM PF14812.6 ELR23301.1 - 3.9 7.9 18.2 2.6 8.5 4.4 2.6 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DNA_pol_phi PF04931.13 ELR23301.1 - 4 5.4 20.4 0.69 7.9 2.0 2.1 2 0 0 2 2 2 0 DNA polymerase phi GOLD_2 PF13897.6 ELR23301.1 - 4.3 7.8 9.5 13 6.2 1.2 2.3 2 0 0 2 2 2 0 Golgi-dynamics membrane-trafficking TRAP_alpha PF03896.16 ELR23301.1 - 4.5 6.4 9.7 7.7 5.6 2.0 2.1 2 0 0 2 2 2 0 Translocon-associated protein (TRAP), alpha subunit DUF4834 PF16118.5 ELR23301.1 - 7.3 7.6 12.3 11 7.1 5.5 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) RR_TM4-6 PF06459.12 ELR23301.1 - 8.5 6.1 14.2 3.4 7.4 5.3 2.2 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 Nucleo_P87 PF07267.11 ELR23301.1 - 8.9 5.0 10.5 1.6 7.5 1.2 2.1 2 0 0 2 2 2 0 Nucleopolyhedrovirus capsid protein P87 AIF_C PF14721.6 ELR23301.1 - 9.9 6.5 6.4 14 6.1 2.2 2.2 2 0 0 2 2 2 0 Apoptosis-inducing factor, mitochondrion-associated, C-term DUF5050 PF16472.5 ELR23303.1 - 0.12 11.6 0.0 0.17 11.1 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5050) WD40 PF00400.32 ELR23304.1 - 2e-14 53.8 0.4 0.011 16.6 0.0 4.8 5 0 0 5 5 5 3 WD domain, G-beta repeat Nucleoporin_N PF08801.11 ELR23304.1 - 6.5e-08 31.7 0.1 0.0035 16.2 0.0 3.9 1 1 2 4 4 4 3 Nup133 N terminal like Nup160 PF11715.8 ELR23304.1 - 0.0016 17.2 1.1 2.1 6.9 0.1 3.9 2 1 1 4 4 4 2 Nucleoporin Nup120/160 PQQ_2 PF13360.6 ELR23304.1 - 0.021 14.4 0.1 1.6 8.3 0.0 2.5 1 1 1 2 2 2 0 PQQ-like domain ANAPC4_WD40 PF12894.7 ELR23304.1 - 0.067 13.5 0.0 2.8 8.3 0.0 3.0 1 1 2 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain PQQ_3 PF13570.6 ELR23304.1 - 0.13 12.7 0.6 1.6e+02 3.0 0.0 4.4 3 2 1 4 4 4 0 PQQ-like domain DUF4773 PF15998.5 ELR23305.1 - 2.7e-14 53.7 0.3 4e-14 53.2 0.3 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4773) Pirin PF02678.16 ELR23305.1 - 0.16 12.0 0.0 1.8 8.6 0.0 2.0 1 1 1 2 2 2 0 Pirin F-box-like PF12937.7 ELR23306.1 - 4.9e-10 39.1 0.1 9.4e-10 38.2 0.1 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ELR23306.1 - 2e-06 27.5 0.0 4.3e-06 26.5 0.0 1.5 1 0 0 1 1 1 1 F-box domain Elongin_A PF06881.11 ELR23306.1 - 0.0011 19.5 0.5 0.0025 18.3 0.5 1.6 1 0 0 1 1 1 1 RNA polymerase II transcription factor SIII (Elongin) subunit A Glu_cyclase_2 PF05096.12 ELR23306.1 - 0.0041 16.6 0.1 0.0061 16.0 0.1 1.2 1 0 0 1 1 1 1 Glutamine cyclotransferase 3-alpha PF03475.14 ELR23306.1 - 0.76 9.7 4.3 66 3.5 0.1 3.3 3 0 0 3 3 3 0 3-alpha domain DUF4792 PF16040.5 ELR23307.1 - 0.067 13.1 0.1 0.079 12.9 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4792) NO_synthase PF02898.15 ELR23307.1 - 0.11 11.5 1.3 0.11 11.5 1.3 1.1 1 0 0 1 1 1 0 Nitric oxide synthase, oxygenase domain WD40 PF00400.32 ELR23308.1 - 4.3e-18 65.4 7.2 4e-07 30.6 0.9 5.1 5 0 0 5 5 5 3 WD domain, G-beta repeat PD40 PF07676.12 ELR23308.1 - 0.046 13.7 0.1 0.11 12.4 0.1 1.6 1 0 0 1 1 1 0 WD40-like Beta Propeller Repeat BBS2_Mid PF14783.6 ELR23308.1 - 0.14 12.2 0.0 3.7 7.6 0.0 2.3 2 0 0 2 2 2 0 Ciliary BBSome complex subunit 2, middle region Pkinase PF00069.25 ELR23309.1 - 4.2e-19 68.9 0.0 9.5e-19 67.8 0.0 1.6 1 1 0 1 1 1 1 Protein kinase domain LRR_8 PF13855.6 ELR23309.1 - 1.5e-18 66.3 3.5 1.1e-07 31.5 2.0 4.0 3 1 1 4 4 4 3 Leucine rich repeat Pkinase_Tyr PF07714.17 ELR23309.1 - 1.6e-14 53.9 0.0 1.5e-13 50.7 0.0 2.2 2 0 0 2 2 2 1 Protein tyrosine kinase LRR_4 PF12799.7 ELR23309.1 - 1.1e-12 47.9 4.9 0.0012 19.2 0.1 4.3 1 1 4 6 6 6 5 Leucine Rich repeats (2 copies) Kdo PF06293.14 ELR23309.1 - 6.2e-07 29.0 0.1 2.8e-06 26.8 0.0 1.9 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 ELR23309.1 - 0.0077 16.2 9.2 0.088 12.7 0.1 3.4 3 2 1 4 4 4 2 Phosphotransferase enzyme family LRR_9 PF14580.6 ELR23309.1 - 0.02 14.4 0.1 0.27 10.7 0.1 2.5 1 1 2 3 3 3 0 Leucine-rich repeat RIO1 PF01163.22 ELR23309.1 - 0.034 13.7 0.0 1.2 8.7 0.0 2.2 2 0 0 2 2 2 0 RIO1 family LRR_6 PF13516.6 ELR23309.1 - 2.2 8.5 6.1 34 4.9 0.1 4.1 5 0 0 5 5 5 0 Leucine Rich repeat DHHA1 PF02272.19 ELR23311.1 - 0.00063 20.2 0.3 0.0014 19.0 0.1 1.8 2 0 0 2 2 2 1 DHHA1 domain DHH PF01368.20 ELR23311.1 - 0.046 14.0 0.0 0.079 13.2 0.0 1.4 1 0 0 1 1 1 0 DHH family RSN1_7TM PF02714.15 ELR23312.1 - 5.2e-66 222.8 22.2 5.2e-66 222.8 22.2 1.9 2 0 0 2 2 2 1 Calcium-dependent channel, 7TM region, putative phosphate RSN1_TM PF13967.6 ELR23312.1 - 1.8e-27 96.1 2.6 1.8e-27 96.1 2.6 3.0 4 0 0 4 4 4 1 Late exocytosis, associated with Golgi transport PHM7_cyt PF14703.6 ELR23312.1 - 5.9e-22 78.7 1.5 5.9e-22 78.7 1.5 3.0 2 2 0 2 2 2 1 Cytosolic domain of 10TM putative phosphate transporter Pkinase PF00069.25 ELR23313.1 - 1.7e-47 162.0 0.0 3.5e-46 157.7 0.0 2.2 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR23313.1 - 3.1e-26 92.2 0.0 5e-26 91.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 ELR23313.1 - 0.0001 22.3 1.0 0.00054 19.9 0.4 2.2 1 1 0 2 2 2 1 Phosphotransferase enzyme family RIO1 PF01163.22 ELR23313.1 - 0.003 17.2 0.1 0.0065 16.1 0.1 1.5 1 0 0 1 1 1 1 RIO1 family Kinase-like PF14531.6 ELR23313.1 - 0.0048 16.3 0.0 0.0086 15.4 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Ribosomal_L19e PF01280.20 ELR23313.1 - 0.017 15.2 6.8 0.28 11.3 4.1 2.4 2 0 0 2 2 2 0 Ribosomal protein L19e Flg_hook PF02120.16 ELR23313.1 - 0.036 14.0 0.1 0.091 12.7 0.1 1.6 1 0 0 1 1 1 0 Flagellar hook-length control protein FliK Kdo PF06293.14 ELR23313.1 - 0.06 12.7 0.2 0.13 11.6 0.2 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Methyltransf_32 PF13679.6 ELR23314.1 - 9.1e-17 61.5 0.7 2.7e-16 59.9 0.7 1.8 1 1 0 1 1 1 1 Methyltransferase domain Actin PF00022.19 ELR23315.1 - 9.4e-103 343.9 0.0 1.2e-101 340.3 0.0 2.1 1 1 0 1 1 1 1 Actin MreB_Mbl PF06723.13 ELR23315.1 - 8e-05 21.6 0.0 0.00014 20.8 0.0 1.4 1 1 0 1 1 1 1 MreB/Mbl protein Cupin_2 PF07883.11 ELR23316.1 - 1.5e-10 40.6 0.0 2.3e-10 40.0 0.0 1.3 1 0 0 1 1 1 1 Cupin domain Cupin_3 PF05899.12 ELR23316.1 - 3.6e-07 29.8 0.0 6.2e-07 29.0 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF861) EutQ PF06249.12 ELR23316.1 - 1.2e-05 25.1 0.0 1.6e-05 24.7 0.0 1.2 1 0 0 1 1 1 1 Ethanolamine utilisation protein EutQ AraC_binding PF02311.19 ELR23316.1 - 2.6e-05 24.1 0.0 3.5e-05 23.7 0.0 1.2 1 0 0 1 1 1 1 AraC-like ligand binding domain CENP-C_C PF11699.8 ELR23316.1 - 0.0042 17.3 0.0 0.0063 16.7 0.0 1.4 1 1 0 1 1 1 1 Mif2/CENP-C like Lyx_isomer PF07385.12 ELR23316.1 - 0.11 11.7 0.0 0.15 11.3 0.0 1.1 1 0 0 1 1 1 0 D-lyxose isomerase TPR_12 PF13424.6 ELR23317.1 - 5.1e-283 914.3 204.6 6.4e-18 64.8 1.7 22.9 6 3 22 28 28 28 28 Tetratricopeptide repeat TPR_10 PF13374.6 ELR23317.1 - 9.4e-223 715.2 86.5 4.9e-12 45.3 0.3 32.1 31 1 1 32 32 32 27 Tetratricopeptide repeat TPR_7 PF13176.6 ELR23317.1 - 2.5e-90 290.1 107.6 5.2e-06 26.1 0.1 30.5 30 1 0 31 31 31 20 Tetratricopeptide repeat TPR_1 PF00515.28 ELR23317.1 - 1.7e-78 255.5 142.8 5.5e-05 22.8 0.3 29.3 30 0 0 30 30 30 22 Tetratricopeptide repeat TPR_2 PF07719.17 ELR23317.1 - 1.9e-76 246.1 154.0 0.00027 20.8 0.1 29.7 31 0 0 31 31 29 22 Tetratricopeptide repeat TPR_8 PF13181.6 ELR23317.1 - 4.9e-59 191.7 141.2 0.0014 18.6 0.2 28.9 31 0 0 31 31 29 19 Tetratricopeptide repeat TPR_16 PF13432.6 ELR23317.1 - 2.6e-43 146.4 75.9 1.6e-05 25.5 4.1 20.7 14 6 6 21 21 19 11 Tetratricopeptide repeat TPR_MalT PF17874.1 ELR23317.1 - 3.2e-42 145.1 53.3 2.2e-06 27.3 0.6 10.5 2 2 6 10 10 10 9 MalT-like TPR region TPR_19 PF14559.6 ELR23317.1 - 1.1e-41 141.2 69.9 0.0025 18.3 0.1 19.0 12 5 9 21 21 19 13 Tetratricopeptide repeat TPR_17 PF13431.6 ELR23317.1 - 1.9e-41 137.5 56.9 0.028 14.8 0.0 26.9 27 0 0 27 27 27 9 Tetratricopeptide repeat TPR_14 PF13428.6 ELR23317.1 - 3.2e-37 124.0 79.9 0.034 15.0 0.6 25.1 17 8 10 28 28 24 9 Tetratricopeptide repeat CLU PF13236.6 ELR23317.1 - 3.7e-27 95.6 0.0 6.7e-27 94.8 0.0 1.5 1 0 0 1 1 1 1 Clustered mitochondria TPR_4 PF07721.14 ELR23317.1 - 4.1e-21 73.4 30.8 0.2 12.4 0.2 18.9 22 0 0 22 22 17 4 Tetratricopeptide repeat ANAPC3 PF12895.7 ELR23317.1 - 2.1e-13 50.3 88.4 0.089 13.0 0.4 17.4 5 3 13 20 20 19 9 Anaphase-promoting complex, cyclosome, subunit 3 SNAP PF14938.6 ELR23317.1 - 1.7e-12 47.4 58.2 3.5e-05 23.4 2.1 9.0 3 3 8 11 11 11 5 Soluble NSF attachment protein, SNAP DUF2225 PF09986.9 ELR23317.1 - 5.6e-09 36.0 56.1 0.21 11.3 1.4 11.1 2 2 4 9 9 9 6 Uncharacterized protein conserved in bacteria (DUF2225) TPR_6 PF13174.6 ELR23317.1 - 1.7e-07 31.4 93.7 0.013 16.1 0.1 21.9 24 0 0 24 24 20 1 Tetratricopeptide repeat TPR_3 PF07720.12 ELR23317.1 - 2.6e-06 27.3 108.6 0.15 12.1 0.1 21.0 22 0 0 22 22 22 5 Tetratricopeptide repeat TPR_9 PF13371.6 ELR23317.1 - 2.9e-06 27.3 26.6 0.53 10.5 0.9 9.6 8 3 0 9 9 8 3 Tetratricopeptide repeat DUF4404 PF14357.6 ELR23317.1 - 2.7e-05 24.7 1.2 5.5 7.7 0.0 8.3 9 1 1 10 10 7 1 Domain of unknown function (DUF4404) Tcf25 PF04910.14 ELR23317.1 - 6.6e-05 22.2 10.8 6.3 5.8 0.0 8.6 9 2 2 11 11 11 1 Transcriptional repressor TCF25 RPN7 PF10602.9 ELR23317.1 - 0.0001 22.1 63.4 4.6 6.9 0.0 17.1 8 6 8 16 16 16 2 26S proteasome subunit RPN7 RPN6_N PF18055.1 ELR23317.1 - 0.00011 22.6 31.6 0.063 13.6 0.2 8.9 8 2 2 10 10 8 2 26S proteasome regulatory subunit RPN6 N-terminal domain PPR PF01535.20 ELR23317.1 - 0.00012 22.1 25.3 21 5.7 0.0 14.3 18 0 0 18 18 17 0 PPR repeat eIF3_p135 PF12807.7 ELR23317.1 - 0.0024 17.9 0.1 0.011 15.7 0.1 1.9 1 1 1 2 2 2 1 Translation initiation factor eIF3 subunit 135 TPR_20 PF14561.6 ELR23317.1 - 0.023 15.0 22.4 11 6.4 0.2 9.3 10 1 1 11 11 9 0 Tetratricopeptide repeat MIT PF04212.18 ELR23317.1 - 0.089 12.9 80.5 1.4 9.1 0.1 16.8 11 6 7 18 18 17 0 MIT (microtubule interacting and transport) domain SPO22 PF08631.10 ELR23317.1 - 0.16 11.5 34.4 0.99 8.8 1.0 8.7 6 3 4 10 10 10 0 Meiosis protein SPO22/ZIP4 like Thioredoxin PF00085.20 ELR23318.1 - 8.8e-20 70.6 0.1 2e-19 69.5 0.1 1.6 2 0 0 2 2 2 1 Thioredoxin Thioredoxin_8 PF13905.6 ELR23318.1 - 0.082 13.2 0.1 0.25 11.7 0.1 1.9 2 0 0 2 2 2 0 Thioredoxin-like Complex1_LYR PF05347.15 ELR23319.1 - 1.4e-06 28.2 0.1 1.9e-06 27.8 0.1 1.2 1 0 0 1 1 1 1 Complex 1 protein (LYR family) SPAM PF02090.15 ELR23319.1 - 0.024 14.5 0.5 0.029 14.2 0.1 1.4 2 0 0 2 2 2 0 Salmonella surface presentation of antigen gene type M protein Complex1_LYR_1 PF13232.6 ELR23319.1 - 0.036 14.6 0.1 0.051 14.2 0.1 1.3 1 1 0 1 1 1 0 Complex1_LYR-like Mitoc_mL59 PF18126.1 ELR23320.1 - 2.2 8.6 6.7 6.3 7.1 6.0 2.1 1 1 0 1 1 1 0 Mitochondrial ribosomal protein mL59 DOT1 PF08123.13 ELR23321.1 - 7.5e-11 41.9 0.0 1e-10 41.5 0.0 1.2 1 0 0 1 1 1 1 Histone methylation protein DOT1 Methyltransf_25 PF13649.6 ELR23321.1 - 0.01 16.5 1.0 0.015 16.0 0.0 1.9 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_11 PF08241.12 ELR23321.1 - 0.16 12.6 0.4 0.73 10.5 0.0 2.3 3 1 0 3 3 3 0 Methyltransferase domain zf-CCHH PF10283.9 ELR23324.1 - 1.3e-11 44.2 3.8 2.7e-11 43.2 3.8 1.6 1 0 0 1 1 1 1 PBZ domain zf-RanBP PF00641.18 ELR23324.1 - 0.00024 20.4 3.5 0.00059 19.1 3.5 1.7 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others FHA_2 PF17913.1 ELR23324.1 - 0.00049 20.3 0.0 0.0011 19.2 0.0 1.5 1 0 0 1 1 1 1 FHA domain FHA PF00498.26 ELR23324.1 - 0.047 14.0 0.0 0.077 13.4 0.0 1.4 1 0 0 1 1 1 0 FHA domain Fer4_19 PF06902.11 ELR23324.1 - 0.067 13.3 0.1 0.15 12.2 0.1 1.5 1 0 0 1 1 1 0 Divergent 4Fe-4S mono-cluster Cofilin_ADF PF00241.20 ELR23325.1 - 5.5e-11 42.3 0.0 7.1e-11 42.0 0.0 1.2 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein Lactamase_B_2 PF12706.7 ELR23326.1 - 7.7e-11 41.9 0.1 1e-06 28.4 0.0 2.1 1 1 1 2 2 2 2 Beta-lactamase superfamily domain Lactamase_B PF00753.27 ELR23326.1 - 0.00096 19.2 2.7 0.0016 18.4 0.7 2.1 2 0 0 2 2 2 1 Metallo-beta-lactamase superfamily Ras PF00071.22 ELR23327.1 - 3.2e-54 182.9 0.0 3.6e-54 182.7 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR23327.1 - 1.2e-17 64.2 0.0 1.9e-17 63.6 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR23327.1 - 1.8e-07 30.8 0.0 2.1e-07 30.6 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 ELR23327.1 - 3.2e-06 26.8 0.2 7.5e-06 25.6 0.2 1.7 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 ELR23327.1 - 0.00021 21.2 0.0 0.23 11.4 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase ATP_bind_1 PF03029.17 ELR23327.1 - 0.00044 20.1 0.1 0.00044 20.1 0.1 1.9 1 1 0 2 2 2 1 Conserved hypothetical ATP binding protein ParA PF10609.9 ELR23327.1 - 0.012 15.0 0.1 0.025 14.0 0.1 1.4 1 0 0 1 1 1 0 NUBPL iron-transfer P-loop NTPase AAA_25 PF13481.6 ELR23327.1 - 0.13 11.8 0.1 0.26 10.8 0.1 1.5 1 0 0 1 1 1 0 AAA domain Sacchrp_dh_NADP PF03435.18 ELR23327.1 - 0.14 12.5 0.1 0.18 12.0 0.1 1.5 1 1 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain AAA_16 PF13191.6 ELR23327.1 - 0.16 12.4 0.1 0.33 11.3 0.1 1.8 1 1 0 1 1 1 0 AAA ATPase domain His_Phos_1 PF00300.22 ELR23329.1 - 1.3e-23 83.8 0.1 6.2e-16 58.7 0.0 2.3 2 0 0 2 2 2 2 Histidine phosphatase superfamily (branch 1) Prok-E2_E PF14462.6 ELR23329.1 - 0.035 13.9 0.0 0.064 13.1 0.0 1.4 1 0 0 1 1 1 0 Prokaryotic E2 family E NUDIX PF00293.28 ELR23330.1 - 3e-11 43.5 0.9 6.6e-11 42.4 0.9 1.5 1 0 0 1 1 1 1 NUDIX domain AvrM-A PF18241.1 ELR23330.1 - 0.034 14.6 0.7 0.076 13.4 0.7 1.5 1 0 0 1 1 1 0 Flax-rust effector AvrM-A YbjQ_1 PF01906.17 ELR23331.1 - 0.00064 20.3 0.2 0.0014 19.3 0.2 1.5 1 0 0 1 1 1 1 Putative heavy-metal-binding PH PF00169.29 ELR23331.1 - 0.036 14.6 0.2 0.071 13.6 0.2 1.5 1 0 0 1 1 1 0 PH domain Utp14 PF04615.13 ELR23331.1 - 0.72 8.4 15.5 2.6 6.5 15.6 1.7 1 1 0 1 1 1 0 Utp14 protein Pkinase PF00069.25 ELR23332.1 - 1.7e-61 207.9 0.1 2.5e-61 207.4 0.1 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR23332.1 - 8.4e-32 110.5 0.1 1.2e-31 109.9 0.1 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase PAS PF00989.25 ELR23332.1 - 1.8e-29 102.0 0.0 2.1e-10 40.6 0.0 4.0 3 1 0 3 3 3 3 PAS fold PAS_9 PF13426.7 ELR23332.1 - 2.2e-26 92.1 0.0 8.9e-09 35.5 0.0 3.6 2 1 1 3 3 3 3 PAS domain PAS_8 PF13188.7 ELR23332.1 - 9.2e-12 44.7 0.0 0.00049 20.0 0.0 3.6 3 0 0 3 3 3 3 PAS domain PAS_4 PF08448.10 ELR23332.1 - 2e-10 40.9 0.0 0.0019 18.4 0.0 3.5 2 1 1 3 3 3 2 PAS fold Kdo PF06293.14 ELR23332.1 - 1.1e-07 31.4 1.5 2.6e-07 30.2 1.5 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 ELR23332.1 - 5.5e-06 26.5 0.3 0.065 13.1 0.1 2.3 1 1 1 2 2 2 2 Phosphotransferase enzyme family PAS_3 PF08447.12 ELR23332.1 - 0.00022 21.4 0.2 0.21 11.9 0.1 2.9 3 0 0 3 3 3 2 PAS fold RIO1 PF01163.22 ELR23332.1 - 0.00027 20.6 1.5 0.00059 19.5 1.5 1.5 1 0 0 1 1 1 1 RIO1 family Haspin_kinase PF12330.8 ELR23332.1 - 0.0012 17.8 0.8 0.0021 17.1 0.8 1.3 1 0 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 ELR23332.1 - 0.054 12.8 0.0 0.094 12.0 0.0 1.4 1 0 0 1 1 1 0 Kinase-like Vinculin PF01044.19 ELR23333.1 - 6.4e-05 21.4 5.1 0.0017 16.7 0.6 4.7 2 1 1 4 4 4 3 Vinculin family Focal_AT PF03623.13 ELR23333.1 - 0.055 13.5 14.0 0.4 10.7 0.0 4.2 4 1 0 4 4 4 0 Focal adhesion targeting region DUF1678 PF07913.11 ELR23333.1 - 0.1 12.3 0.2 1.7 8.4 0.3 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1678) Toxin_36 PF10550.9 ELR23333.1 - 0.2 13.1 1.1 0.57 11.6 0.1 2.5 2 0 0 2 2 2 0 Conantokin-G mollusc-toxin Globin PF00042.22 ELR23333.1 - 1.4 9.5 9.1 4.8 7.8 0.1 4.4 4 0 0 4 4 4 0 Globin DinB_2 PF12867.7 ELR23333.1 - 3.5 8.1 8.2 9.3 6.8 1.1 3.5 3 0 0 3 3 3 0 DinB superfamily DUF3631 PF12307.8 ELR23333.1 - 4.8 7.4 7.8 0.79 9.9 1.2 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3631) Syntaxin-6_N PF09177.11 ELR23333.1 - 9 6.9 8.2 41 4.8 0.0 5.0 5 1 1 7 7 7 0 Syntaxin 6, N-terminal PfkB PF00294.24 ELR23335.1 - 1.8e-07 30.7 0.0 2.9e-07 30.1 0.0 1.3 1 0 0 1 1 1 1 pfkB family carbohydrate kinase HemY_N PF07219.13 ELR23337.1 - 0.3 11.3 0.0 0.3 11.3 0.0 3.3 3 1 0 3 3 3 0 HemY protein N-terminus P66_CC PF16563.5 ELR23337.1 - 0.43 10.2 2.9 1.1 8.9 2.9 1.7 1 0 0 1 1 1 0 Coiled-coil and interaction region of P66A and P66B with MBD2 WD40 PF00400.32 ELR23338.1 - 4.3e-09 36.9 2.6 0.00019 22.1 0.0 4.9 4 0 0 4 4 4 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ELR23338.1 - 1.2e-06 28.7 0.0 3.8e-05 23.9 0.0 2.9 2 1 0 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain DUF4471 PF14740.6 ELR23338.1 - 0.011 15.0 0.3 0.016 14.5 0.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4471) BBS2_N PF14781.6 ELR23338.1 - 0.011 15.6 0.1 1.8 8.5 0.1 2.9 2 1 0 2 2 2 0 Ciliary BBSome complex subunit 2, N-terminal RAB3GAP2_N PF14655.6 ELR23338.1 - 0.062 12.6 0.0 0.29 10.3 0.0 1.8 2 0 0 2 2 2 0 Rab3 GTPase-activating protein regulatory subunit N-terminus DUF1840 PF08895.11 ELR23338.1 - 0.29 11.5 1.5 0.73 10.2 1.5 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF1840) Dcc1 PF09724.9 ELR23339.1 - 1.3e-72 245.0 0.3 4e-58 197.3 0.0 2.0 1 1 1 2 2 2 2 Sister chromatid cohesion protein Dcc1 TruB_N PF01509.18 ELR23340.1 - 6e-50 169.5 0.0 8.5e-50 169.0 0.0 1.2 1 0 0 1 1 1 1 TruB family pseudouridylate synthase (N terminal domain) TruB_C_2 PF16198.5 ELR23340.1 - 0.00019 21.5 0.0 0.00036 20.6 0.0 1.4 1 0 0 1 1 1 1 tRNA pseudouridylate synthase B C-terminal domain FUSC_2 PF13515.6 ELR23342.1 - 3.3e-13 49.9 9.3 3.3e-13 49.9 9.3 2.7 2 1 0 2 2 2 1 Fusaric acid resistance protein-like ALMT PF11744.8 ELR23342.1 - 6e-09 35.3 11.5 4.6e-07 29.0 5.6 2.3 2 0 0 2 2 2 2 Aluminium activated malate transporter FUSC PF04632.12 ELR23342.1 - 2e-08 33.3 6.3 2e-08 33.3 6.3 2.8 3 0 0 3 3 3 2 Fusaric acid resistance protein family ArAE_2_N PF10337.9 ELR23342.1 - 0.045 12.8 1.4 0.11 11.5 0.0 2.2 2 1 0 2 2 2 0 Putative ER transporter, 6TM, N-terminal RhoGEF PF00621.20 ELR23343.1 - 3.3e-52 177.4 0.0 4.6e-52 176.9 0.0 1.2 1 0 0 1 1 1 1 RhoGEF domain PH PF00169.29 ELR23343.1 - 2.7e-06 27.8 0.0 5e-06 27.0 0.0 1.4 1 0 0 1 1 1 1 PH domain PH_13 PF16652.5 ELR23343.1 - 0.001 18.9 0.6 0.13 12.0 0.1 2.4 1 1 1 2 2 2 2 Pleckstrin homology domain Cullin_binding PF03556.15 ELR23344.1 - 3.2e-33 114.7 4.4 3.2e-33 114.7 4.4 1.8 2 0 0 2 2 2 1 Cullin binding UBA_4 PF14555.6 ELR23344.1 - 4.2e-07 29.7 2.2 1.5e-06 27.9 1.0 2.4 2 0 0 2 2 2 1 UBA-like domain DSPc PF00782.20 ELR23345.1 - 8.5e-11 41.8 0.0 2.1e-10 40.5 0.0 1.8 1 1 0 1 1 1 1 Dual specificity phosphatase, catalytic domain ZZ PF00569.17 ELR23345.1 - 2.6e-06 27.1 0.8 1.2e-05 25.0 0.7 2.0 2 0 0 2 2 2 1 Zinc finger, ZZ type Init_tRNA_PT PF04179.12 ELR23345.1 - 0.073 13.4 0.0 0.2 12.0 0.0 1.7 1 0 0 1 1 1 0 Rit1 DUSP-like domain PRY PF13765.6 ELR23346.1 - 0.086 12.5 0.8 0.17 11.5 0.1 1.9 2 0 0 2 2 2 0 SPRY-associated domain zinc_ribbon_2 PF13240.6 ELR23346.1 - 0.24 11.2 4.2 0.38 10.5 4.2 1.3 1 0 0 1 1 1 0 zinc-ribbon domain zf-ribbon_3 PF13248.6 ELR23346.1 - 0.5 9.8 3.6 0.84 9.1 3.6 1.3 1 0 0 1 1 1 0 zinc-ribbon domain CTP_synth_N PF06418.14 ELR23347.1 - 1.5e-122 408.0 0.0 2e-122 407.6 0.0 1.2 1 0 0 1 1 1 1 CTP synthase N-terminus GATase PF00117.28 ELR23347.1 - 5.9e-48 163.2 0.0 1.3e-47 162.0 0.0 1.6 1 1 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.13 ELR23347.1 - 0.026 14.3 0.2 1.7 8.3 0.0 2.5 2 0 0 2 2 2 0 Peptidase C26 CbiA PF01656.23 ELR23347.1 - 0.038 14.0 0.0 0.06 13.4 0.0 1.5 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain NodZ PF05830.11 ELR23347.1 - 0.15 10.8 0.0 0.27 10.0 0.0 1.3 1 0 0 1 1 1 0 Nodulation protein Z (NodZ) IF4E PF01652.18 ELR23348.1 - 4.8e-56 189.0 0.9 6.1e-56 188.6 0.9 1.1 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E Ribosomal_S24e PF01282.19 ELR23349.1 - 1.6e-33 114.5 0.1 1.6e-33 114.5 0.1 1.5 2 0 0 2 2 2 1 Ribosomal protein S24e DUF4023 PF13215.6 ELR23349.1 - 6.9 6.8 9.2 4.7 7.3 7.2 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF4023) Frizzled PF01534.17 ELR23350.1 - 5.6e-18 65.1 17.0 7.7e-18 64.6 17.0 1.1 1 0 0 1 1 1 1 Frizzled/Smoothened family membrane region Dicty_CAR PF05462.11 ELR23350.1 - 5.7e-08 32.3 8.2 9.8e-08 31.5 8.2 1.3 1 0 0 1 1 1 1 Slime mold cyclic AMP receptor Fz PF01392.22 ELR23350.1 - 1.2e-06 29.1 0.9 2.4e-06 28.1 0.9 1.4 1 0 0 1 1 1 1 Fz domain DUF1772 PF08592.11 ELR23350.1 - 9.8 6.5 13.8 26 5.1 6.5 2.9 2 1 0 2 2 2 0 Domain of unknown function (DUF1772) Glyco_transf_22 PF03901.17 ELR23351.1 - 5.3e-83 279.6 27.6 6.6e-83 279.3 27.6 1.1 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family TCTP PF00838.17 ELR23352.1 - 1.7e-55 187.9 4.4 1.9e-55 187.7 4.4 1.0 1 0 0 1 1 1 1 Translationally controlled tumour protein Ribosomal_S25 PF03297.15 ELR23353.1 - 1.3e-35 121.7 6.1 1.3e-35 121.7 6.1 1.5 1 1 1 2 2 2 1 S25 ribosomal protein HTH_24 PF13412.6 ELR23353.1 - 0.00039 19.9 0.3 0.00075 19.0 0.3 1.5 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding MarR_2 PF12802.7 ELR23353.1 - 0.00081 19.2 0.0 0.0013 18.6 0.0 1.3 1 0 0 1 1 1 1 MarR family DUF3516 PF12029.8 ELR23353.1 - 0.036 13.1 0.5 0.042 12.9 0.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3516) TrmB PF01978.19 ELR23353.1 - 0.041 13.8 0.0 0.07 13.0 0.0 1.4 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB AIPR PF10592.9 ELR23353.1 - 0.058 13.0 0.3 0.069 12.8 0.3 1.1 1 0 0 1 1 1 0 AIPR protein EAP30 PF04157.16 ELR23353.1 - 0.095 12.0 0.2 0.27 10.5 0.2 1.7 1 1 0 1 1 1 0 EAP30/Vps36 family HTH_IclR PF09339.10 ELR23353.1 - 0.11 12.4 0.0 0.18 11.6 0.0 1.4 1 0 0 1 1 1 0 IclR helix-turn-helix domain RPA_C PF08784.11 ELR23353.1 - 0.28 11.9 1.6 0.8 10.4 1.6 1.7 1 1 0 1 1 1 0 Replication protein A C terminal LNS2 PF08235.13 ELR23354.1 - 4.6e-95 317.4 0.0 6.1e-95 317.0 0.0 1.2 1 0 0 1 1 1 1 LNS2 (Lipin/Ned1/Smp2) Lipin_N PF04571.14 ELR23354.1 - 2.5e-25 88.4 0.1 5.6e-25 87.3 0.1 1.5 1 0 0 1 1 1 1 lipin, N-terminal conserved region Lipin_mid PF16876.5 ELR23354.1 - 8.4e-14 51.6 0.5 3.7e-13 49.5 0.0 2.4 2 0 0 2 2 2 1 Lipin/Ned1/Smp2 multi-domain protein middle domain F-box-like PF12937.7 ELR23355.1 - 9.3e-09 35.0 0.9 9.3e-09 35.0 0.9 1.7 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 ELR23355.1 - 0.00011 21.9 2.4 0.00027 20.7 2.4 1.7 1 0 0 1 1 1 1 F-box domain DUF3744 PF12558.8 ELR23355.1 - 0.12 13.2 0.0 0.22 12.3 0.0 1.5 1 0 0 1 1 1 0 ATP-binding cassette cobalt transporter RhoGAP PF00620.27 ELR23356.1 - 3.3e-14 53.0 0.0 5e-14 52.4 0.0 1.2 1 0 0 1 1 1 1 RhoGAP domain PH PF00169.29 ELR23356.1 - 6.9e-13 49.0 0.0 6.2e-11 42.8 0.0 2.3 2 0 0 2 2 2 1 PH domain PH_3 PF14593.6 ELR23356.1 - 0.0083 16.2 0.0 0.018 15.1 0.0 1.5 1 0 0 1 1 1 1 PH domain PH_8 PF15409.6 ELR23356.1 - 0.017 15.4 1.6 0.036 14.4 0.4 2.2 2 1 0 2 2 2 0 Pleckstrin homology domain PH_11 PF15413.6 ELR23356.1 - 0.02 15.3 0.6 0.05 14.0 0.6 1.8 1 1 0 1 1 1 0 Pleckstrin homology domain zf-RING_2 PF13639.6 ELR23357.1 - 1.3e-08 35.0 7.4 1.3e-08 35.0 7.4 2.8 2 1 1 3 3 3 1 Ring finger domain zf-Di19 PF05605.12 ELR23357.1 - 8.4e-08 32.4 3.2 1.9e-07 31.2 3.2 1.6 1 0 0 1 1 1 1 Drought induced 19 protein (Di19), zinc-binding zf-RING_11 PF17123.5 ELR23357.1 - 0.00015 21.4 5.4 0.00015 21.4 5.4 2.6 2 1 0 2 2 2 1 RING-like zinc finger Zn_ribbon_17 PF17120.5 ELR23357.1 - 0.00029 20.4 5.1 0.00029 20.4 5.1 3.1 3 0 0 3 3 3 1 Zinc-ribbon, C4HC2 type zf-C3HC4_2 PF13923.6 ELR23357.1 - 0.00044 20.0 5.5 0.00044 20.0 5.5 3.1 4 0 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 ELR23357.1 - 0.012 15.8 8.4 0.012 15.8 8.4 3.0 2 2 0 2 2 2 0 RING-H2 zinc finger domain zf-RING_UBOX PF13445.6 ELR23357.1 - 0.026 14.6 5.1 0.026 14.6 5.1 3.0 3 0 0 3 3 3 0 RING-type zinc-finger Baculo_RING PF05883.11 ELR23357.1 - 0.039 13.9 0.5 0.089 12.8 0.5 1.6 1 0 0 1 1 1 0 Baculovirus U-box/Ring-like domain zf-Nse PF11789.8 ELR23357.1 - 0.11 12.3 8.2 0.72 9.7 1.6 3.1 3 0 0 3 3 3 0 Zinc-finger of the MIZ type in Nse subunit DUF4729 PF15866.5 ELR23357.1 - 0.19 11.0 5.4 0.091 12.1 1.6 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4729) zf-RING_5 PF14634.6 ELR23357.1 - 0.35 10.9 12.8 0.56 10.2 5.1 2.7 2 0 0 2 2 2 0 zinc-RING finger domain RINGv PF12906.7 ELR23357.1 - 0.7 10.1 13.1 0.19 11.9 6.2 3.0 2 2 1 3 3 3 0 RING-variant domain zf-C3HC4 PF00097.25 ELR23357.1 - 1.8 8.5 15.1 0.096 12.6 4.9 3.1 3 1 1 4 4 4 0 Zinc finger, C3HC4 type (RING finger) FANCL_C PF11793.8 ELR23357.1 - 3.5 7.9 16.9 0.061 13.5 5.5 3.0 2 1 1 3 3 3 0 FANCL C-terminal domain zf-RING-like PF08746.11 ELR23357.1 - 8.4 6.8 15.6 0.1 12.9 5.1 2.6 2 1 0 2 2 2 0 RING-like domain RhoGEF PF00621.20 ELR23358.1 - 2.1e-40 138.9 0.2 4.3e-40 137.9 0.2 1.5 1 0 0 1 1 1 1 RhoGEF domain PH PF00169.29 ELR23358.1 - 3.5e-08 33.9 0.1 9.9e-08 32.4 0.1 1.8 1 0 0 1 1 1 1 PH domain IQ_SEC7_PH PF16453.5 ELR23358.1 - 0.00011 22.2 0.1 0.00021 21.3 0.1 1.4 1 0 0 1 1 1 1 PH domain Cullin PF00888.22 ELR23359.1 - 5e-197 656.3 1.0 6.4e-197 656.0 1.0 1.1 1 0 0 1 1 1 1 Cullin family Cullin_Nedd8 PF10557.9 ELR23359.1 - 2.7e-26 91.4 1.0 8.1e-26 89.9 1.0 1.9 1 0 0 1 1 1 1 Cullin protein neddylation domain Imm42 PF15593.6 ELR23359.1 - 0.025 15.1 1.1 17 5.9 0.5 3.4 3 0 0 3 3 3 0 Immunity protein 42 PP2C PF00481.21 ELR23360.1 - 3e-56 190.9 0.0 4.1e-56 190.5 0.0 1.2 1 0 0 1 1 1 1 Protein phosphatase 2C LRR_8 PF13855.6 ELR23360.1 - 1.2e-51 172.3 30.8 1.5e-08 34.3 0.1 9.7 4 3 7 11 11 11 11 Leucine rich repeat LRR_4 PF12799.7 ELR23360.1 - 2.2e-44 148.7 19.6 2.5e-06 27.7 0.1 11.1 6 3 4 11 11 11 9 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 ELR23360.1 - 6.1e-11 42.1 4.7 0.0023 17.4 0.0 5.5 3 2 3 6 6 6 4 Leucine-rich repeat LRR_1 PF00560.33 ELR23360.1 - 2e-08 33.7 17.9 12 6.9 0.1 12.4 15 1 0 15 15 15 1 Leucine Rich Repeat LRR_6 PF13516.6 ELR23360.1 - 3.9e-08 32.7 20.6 4 7.7 0.1 11.0 12 0 0 12 12 12 2 Leucine Rich repeat PP2C_2 PF13672.6 ELR23360.1 - 0.00074 19.2 0.2 0.0013 18.4 0.2 1.3 1 0 0 1 1 1 1 Protein phosphatase 2C DUF4407 PF14362.6 ELR23360.1 - 0.14 11.5 0.4 0.28 10.5 0.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Frizzled PF01534.17 ELR23361.1 - 9.6e-17 61.0 14.0 2.9e-12 46.3 0.6 2.2 2 0 0 2 2 2 2 Frizzled/Smoothened family membrane region UPF0220 PF05255.11 ELR23361.1 - 0.0094 15.5 4.3 0.026 14.1 4.3 1.7 1 1 0 1 1 1 1 Uncharacterised protein family (UPF0220) T5orf172 PF10544.9 ELR23363.1 - 2e-10 41.1 0.0 5.1e-10 39.8 0.0 1.7 1 0 0 1 1 1 1 T5orf172 domain MUG113 PF13455.6 ELR23363.1 - 3.1e-10 40.6 0.0 6.6e-10 39.5 0.0 1.5 1 0 0 1 1 1 1 Meiotically up-regulated gene 113 MFS_1 PF07690.16 ELR23364.1 - 4.1e-27 95.0 42.3 8.6e-22 77.5 17.1 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 ELR23364.1 - 3e-23 82.4 18.5 9.3e-22 77.5 18.5 2.8 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1_like PF12832.7 ELR23364.1 - 0.12 11.3 10.2 0.046 12.6 1.6 2.7 2 1 1 3 3 3 0 MFS_1 like family F-box-like PF12937.7 ELR23366.1 - 9.9e-09 35.0 0.2 3.2e-07 30.1 0.2 3.0 3 0 0 3 3 3 1 F-box-like PQQ_2 PF13360.6 ELR23366.1 - 0.034 13.7 0.1 0.53 9.8 0.0 2.3 2 1 0 2 2 2 0 PQQ-like domain F-box PF00646.33 ELR23366.1 - 0.093 12.6 0.3 0.093 12.6 0.3 2.2 2 1 0 2 2 2 0 F-box domain DUF2811 PF10929.8 ELR23367.1 - 0.18 12.1 1.0 12 6.2 0.1 3.1 4 0 0 4 4 4 0 Protein of unknown function (DUF2811) UCH PF00443.29 ELR23368.1 - 7.6e-14 51.8 1.6 6.3e-11 42.2 0.1 2.2 2 1 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 ELR23368.1 - 0.0023 17.6 1.2 0.0023 17.6 1.2 1.9 1 1 1 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase DUF1068 PF06364.12 ELR23368.1 - 0.0075 16.2 0.0 0.0075 16.2 0.0 2.4 2 1 1 3 3 3 1 Protein of unknown function (DUF1068) Zip PF02535.22 ELR23369.1 - 1.1e-47 163.0 2.0 1.3e-47 162.7 2.0 1.0 1 0 0 1 1 1 1 ZIP Zinc transporter CytochromB561_N PF09786.9 ELR23369.1 - 0.052 12.6 0.0 0.066 12.2 0.0 1.1 1 0 0 1 1 1 0 Cytochrome B561, N terminal G0-G1_switch_2 PF15103.6 ELR23369.1 - 0.061 13.8 0.7 0.21 12.0 0.7 1.9 1 1 0 1 1 1 0 G0/G1 switch protein 2 Pep_deformylase PF01327.21 ELR23370.1 - 1.4e-39 135.2 0.0 1.7e-39 135.0 0.0 1.1 1 0 0 1 1 1 1 Polypeptide deformylase Frizzled PF01534.17 ELR23372.1 - 7.2e-28 97.6 8.7 9.5e-28 97.2 8.7 1.1 1 0 0 1 1 1 1 Frizzled/Smoothened family membrane region 7tm_2 PF00002.24 ELR23372.1 - 6.4e-10 38.7 6.1 1e-09 38.1 6.1 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) Fz PF01392.22 ELR23372.1 - 3e-07 31.0 2.2 5.3e-07 30.2 2.2 1.4 1 0 0 1 1 1 1 Fz domain Dicty_CAR PF05462.11 ELR23372.1 - 9.8e-07 28.2 5.0 1.8e-06 27.3 5.0 1.3 1 0 0 1 1 1 1 Slime mold cyclic AMP receptor RCC1 PF00415.18 ELR23373.1 - 1e-29 102.9 34.1 9.5e-08 32.5 0.2 8.0 7 1 0 7 7 7 6 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 ELR23373.1 - 5.6e-09 35.6 34.3 5e-06 26.2 1.2 8.0 8 1 0 8 8 8 4 Regulator of chromosome condensation (RCC1) repeat SET PF00856.28 ELR23374.1 - 2.8e-13 50.6 3.2 8.3e-13 49.1 0.4 2.6 2 1 0 2 2 2 1 SET domain zf-MYND PF01753.18 ELR23374.1 - 0.021 14.9 14.6 0.044 13.9 12.9 2.5 1 1 1 2 2 2 0 MYND finger DUF3856 PF12968.7 ELR23374.1 - 0.055 13.5 0.5 0.25 11.4 0.5 2.1 1 1 0 1 1 1 0 Domain of Unknown Function (DUF3856) SAF PF08666.12 ELR23374.1 - 0.15 12.7 0.0 15 6.3 0.0 3.2 3 0 0 3 3 3 0 SAF domain TPR_14 PF13428.6 ELR23374.1 - 2.7 9.0 5.2 31 5.7 1.8 3.2 1 1 1 2 2 2 0 Tetratricopeptide repeat START PF01852.19 ELR23375.1 - 5.5e-13 48.8 0.5 6.9e-13 48.5 0.5 1.1 1 0 0 1 1 1 1 START domain Proteasome PF00227.26 ELR23376.1 - 8.5e-48 162.4 0.3 9.6e-48 162.2 0.3 1.0 1 0 0 1 1 1 1 Proteasome subunit VIT PF08487.10 ELR23377.1 - 2.3e-39 134.0 0.0 9e-39 132.1 0.0 2.1 1 0 0 1 1 1 1 Vault protein inter-alpha-trypsin domain PARP PF00644.20 ELR23377.1 - 4.7e-32 111.2 0.0 1.6e-31 109.5 0.0 1.9 1 1 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain VWA_3 PF13768.6 ELR23377.1 - 1.3e-11 44.7 0.0 1.6e-09 37.9 0.0 2.5 1 1 0 1 1 1 1 von Willebrand factor type A domain VIT_2 PF13757.6 ELR23377.1 - 2.8e-11 43.1 0.0 6.5e-11 42.0 0.0 1.6 1 0 0 1 1 1 1 Vault protein inter-alpha-trypsin domain PARP_reg PF02877.14 ELR23377.1 - 1e-09 38.6 0.5 2.3e-09 37.5 0.5 1.6 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase, regulatory domain Slu7 PF11708.8 ELR23377.1 - 1.3e-07 31.7 20.1 1.3e-07 31.7 20.1 3.3 2 1 0 2 2 2 1 Pre-mRNA splicing Prp18-interacting factor VWA PF00092.28 ELR23377.1 - 3.5e-07 30.6 0.0 1.6e-05 25.2 0.0 2.4 1 1 0 1 1 1 1 von Willebrand factor type A domain BRCT PF00533.26 ELR23377.1 - 5.7e-06 26.6 0.0 1.3e-05 25.4 0.0 1.7 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 ELR23377.1 - 2.2e-05 24.8 0.0 7.3e-05 23.1 0.0 1.9 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain VWA_2 PF13519.6 ELR23377.1 - 0.0012 19.5 0.0 0.0073 16.9 0.0 2.4 1 1 0 1 1 1 1 von Willebrand factor type A domain Pkinase_Tyr PF07714.17 ELR23378.1 - 1.7e-42 145.5 0.0 3.2e-42 144.6 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ELR23378.1 - 1.1e-37 129.9 0.0 3.2e-37 128.3 0.0 1.8 1 1 0 1 1 1 1 Protein kinase domain Guanylate_cyc PF00211.20 ELR23378.1 - 3.4e-05 23.5 0.0 5.6e-05 22.8 0.0 1.3 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain APH PF01636.23 ELR23378.1 - 3.6e-05 23.8 0.6 6.6e-05 22.9 0.0 1.7 2 0 0 2 2 2 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 ELR23378.1 - 0.0025 16.8 0.0 0.0037 16.3 0.0 1.1 1 0 0 1 1 1 1 Haspin like kinase domain 4HBT PF03061.22 ELR23379.1 - 6.6e-21 74.5 4.0 5.5e-10 39.5 0.2 2.2 2 0 0 2 2 2 2 Thioesterase superfamily HGTP_anticodon PF03129.20 ELR23380.1 - 4.8e-20 71.5 0.0 9.9e-20 70.5 0.0 1.6 1 0 0 1 1 1 1 Anticodon binding domain tRNA-synt_2b PF00587.25 ELR23380.1 - 1.2e-10 41.6 0.4 5.1e-07 29.8 0.1 2.8 3 0 0 3 3 3 2 tRNA synthetase class II core domain (G, H, P, S and T) Oxidored_FMN PF00724.20 ELR23381.1 - 1.8e-75 254.3 0.0 2.3e-75 254.0 0.0 1.1 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family Dus PF01207.17 ELR23381.1 - 0.014 14.5 0.0 0.21 10.7 0.0 2.1 2 0 0 2 2 2 0 Dihydrouridine synthase (Dus) Esterase_phd PF10503.9 ELR23383.1 - 0.0068 15.9 3.4 0.016 14.7 0.5 2.5 3 0 0 3 3 3 1 Esterase PHB depolymerase Peptidase_S9 PF00326.21 ELR23383.1 - 0.017 14.6 0.0 0.033 13.7 0.0 1.5 1 1 0 1 1 1 0 Prolyl oligopeptidase family DLH PF01738.18 ELR23383.1 - 0.019 14.6 0.0 0.028 14.0 0.0 1.2 1 0 0 1 1 1 0 Dienelactone hydrolase family Hydrolase_4 PF12146.8 ELR23383.1 - 0.021 14.1 0.0 0.037 13.3 0.0 1.4 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Esterase PF00756.20 ELR23383.1 - 0.1 12.2 0.0 0.92 9.1 0.0 2.1 2 0 0 2 2 2 0 Putative esterase AXE1 PF05448.12 ELR23383.1 - 0.19 10.3 0.1 0.31 9.7 0.1 1.2 1 0 0 1 1 1 0 Acetyl xylan esterase (AXE1) Abhydrolase_6 PF12697.7 ELR23383.1 - 0.2 12.2 5.6 0.14 12.8 3.6 1.7 2 1 0 2 2 2 0 Alpha/beta hydrolase family SR-25 PF10500.9 ELR23383.1 - 1 9.0 7.0 1.4 8.4 7.0 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein DUF1729 PF08354.10 ELR23384.1 - 1.6e-137 458.1 0.0 2.7e-137 457.4 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1729) FAS_I_H PF18314.1 ELR23384.1 - 3.3e-68 229.3 0.2 9e-68 227.9 0.2 1.8 1 0 0 1 1 1 1 Fatty acid synthase type I helical domain Acyl_transf_1 PF00698.21 ELR23384.1 - 1.3e-55 189.2 0.2 1.4e-53 182.5 0.0 3.5 3 1 1 4 4 4 1 Acyl transferase domain Fas_alpha_ACP PF18325.1 ELR23384.1 - 8.3e-45 153.0 0.0 2.3e-44 151.6 0.0 1.8 1 0 0 1 1 1 1 Fatty acid synthase subunit alpha Acyl carrier domain FAS_meander PF17951.1 ELR23384.1 - 1.8e-24 86.2 0.0 4.8e-24 84.8 0.0 1.8 1 0 0 1 1 1 1 Fatty acid synthase meander beta sheet domain ketoacyl-synt PF00109.26 ELR23384.1 - 1.7e-22 80.3 0.3 4.5e-22 78.8 0.3 1.7 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain MaoC_dehydratas PF01575.19 ELR23384.1 - 5.1e-21 74.5 0.0 1.6e-20 72.9 0.0 1.8 1 0 0 1 1 1 1 MaoC like domain SAT PF16073.5 ELR23384.1 - 7.4e-20 71.7 0.0 1.5e-18 67.4 0.0 2.8 2 1 0 2 2 2 1 Starter unit:ACP transacylase in aflatoxin biosynthesis ACPS PF01648.20 ELR23384.1 - 2.9e-14 53.2 0.0 7.8e-14 51.8 0.0 1.8 1 0 0 1 1 1 1 4'-phosphopantetheinyl transferase superfamily Ketoacyl-synt_C PF02801.22 ELR23384.1 - 4.4e-11 42.8 0.0 1.4e-10 41.2 0.0 1.9 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain MaoC_dehydrat_N PF13452.6 ELR23384.1 - 3e-05 24.1 0.0 0.00012 22.3 0.0 2.0 1 0 0 1 1 1 1 N-terminal half of MaoC dehydratase NMO PF03060.15 ELR23384.1 - 0.00094 18.7 0.2 0.0055 16.1 0.2 2.3 1 1 0 1 1 1 1 Nitronate monooxygenase KR PF08659.10 ELR23384.1 - 0.053 13.4 0.0 0.23 11.3 0.0 2.1 2 0 0 2 2 2 0 KR domain DEAD PF00270.29 ELR23385.1 - 4.5e-48 163.3 0.0 9.7e-48 162.2 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ELR23385.1 - 2.8e-27 95.2 0.0 4e-26 91.5 0.1 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 ELR23385.1 - 4.6e-06 26.7 0.0 1.2e-05 25.4 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Pkinase_Tyr PF07714.17 ELR23386.1 - 3.6e-123 409.9 0.0 2.9e-61 207.0 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 ELR23386.1 - 1.9e-108 361.8 0.0 4.3e-56 190.2 0.0 2.3 2 0 0 2 2 2 2 Protein kinase domain PBP_like_2 PF12849.7 ELR23386.1 - 5.6e-33 114.8 14.7 8.7e-17 61.7 3.5 2.8 3 0 0 3 3 3 2 PBP superfamily domain Guanylate_cyc PF00211.20 ELR23386.1 - 9.9e-14 51.4 0.0 1.8e-13 50.5 0.0 1.3 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain APH PF01636.23 ELR23386.1 - 9.6e-07 29.0 0.1 0.00044 20.3 0.0 2.5 2 0 0 2 2 2 2 Phosphotransferase enzyme family Haspin_kinase PF12330.8 ELR23386.1 - 0.00031 19.8 0.0 0.034 13.1 0.0 2.5 3 0 0 3 3 3 1 Haspin like kinase domain Pkinase_fungal PF17667.1 ELR23386.1 - 0.0021 16.9 0.0 0.57 8.9 0.0 2.2 2 0 0 2 2 2 2 Fungal protein kinase Kdo PF06293.14 ELR23386.1 - 0.0037 16.7 0.4 1.6 8.1 0.1 2.3 2 0 0 2 2 2 2 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 ELR23386.1 - 0.0037 16.6 0.0 0.48 9.7 0.0 2.3 2 0 0 2 2 2 1 Kinase-like FTA2 PF13095.6 ELR23386.1 - 0.0056 16.3 0.1 0.17 11.5 0.0 2.9 3 1 1 4 4 4 1 Kinetochore Sim4 complex subunit FTA2 RIO1 PF01163.22 ELR23386.1 - 0.019 14.6 0.5 0.69 9.5 0.1 2.4 2 0 0 2 2 2 0 RIO1 family EGF_2 PF07974.13 ELR23386.1 - 0.14 12.6 7.0 0.27 11.6 7.0 1.5 1 0 0 1 1 1 0 EGF-like domain Colipase-like PF15083.6 ELR23386.1 - 1.1 9.5 3.8 2.4 8.3 3.8 1.5 1 0 0 1 1 1 0 Colipase-like PPR_2 PF13041.6 ELR23387.1 - 2e-40 136.7 1.8 8.6e-06 25.9 0.0 12.1 6 4 7 13 13 13 9 PPR repeat family PPR_3 PF13812.6 ELR23387.1 - 3.1e-35 120.0 0.2 4.5e-09 36.2 0.0 8.2 4 2 3 8 8 8 6 Pentatricopeptide repeat domain PPR_long PF17177.4 ELR23387.1 - 3e-32 111.7 1.2 3.6e-13 49.4 0.0 3.8 1 1 2 3 3 3 3 Pentacotripeptide-repeat region of PRORP PPR PF01535.20 ELR23387.1 - 1.1e-25 88.0 5.3 0.0036 17.5 0.0 11.9 12 1 0 12 12 12 7 PPR repeat PPR_1 PF12854.7 ELR23387.1 - 1.5e-13 50.2 3.2 0.11 12.3 0.0 9.0 10 1 0 10 10 10 3 PPR repeat Hormone_recep PF00104.30 ELR23387.1 - 0.0012 18.5 0.2 0.21 11.2 0.1 2.5 2 0 0 2 2 2 1 Ligand-binding domain of nuclear hormone receptor TPR_19 PF14559.6 ELR23387.1 - 0.0017 18.8 10.0 3.3 8.3 0.4 5.6 6 1 1 7 7 6 2 Tetratricopeptide repeat COX5A PF02284.16 ELR23387.1 - 0.0018 18.3 1.2 6.2 6.9 0.0 4.7 4 1 1 5 5 5 1 Cytochrome c oxidase subunit Va ECSIT PF06239.11 ELR23387.1 - 0.012 14.8 0.1 6 5.9 0.0 3.6 3 1 0 3 3 3 0 Evolutionarily conserved signalling intermediate in Toll pathway TPR_15 PF13429.6 ELR23387.1 - 0.018 14.3 1.9 5.3 6.2 0.0 4.0 5 0 0 5 5 5 0 Tetratricopeptide repeat Suv3_N PF18114.1 ELR23387.1 - 0.12 12.5 1.5 3.7 7.7 0.1 3.7 3 1 0 3 3 3 0 Suv3 helical N-terminal domain Glyco_hydro_25 PF01183.20 ELR23388.1 - 7.4e-07 29.5 0.4 9.2e-07 29.2 0.4 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 25 DUF1610 PF07754.11 ELR23388.1 - 0.012 15.5 1.5 0.033 14.2 1.5 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF1610) zf_Rg PF17915.1 ELR23388.1 - 0.2 11.1 0.5 0.44 10.0 0.5 1.5 1 0 0 1 1 1 0 Reverse gyrase zinc finger Beta-lactamase PF00144.24 ELR23389.1 - 2.1e-40 139.0 0.2 3.3e-40 138.3 0.2 1.2 1 0 0 1 1 1 1 Beta-lactamase NAGidase PF07555.13 ELR23390.1 - 1.5e-57 195.1 0.0 2.1e-57 194.7 0.0 1.2 1 0 0 1 1 1 1 beta-N-acetylglucosaminidase Mgm101p PF06420.12 ELR23390.1 - 0.13 11.7 0.0 0.29 10.6 0.0 1.5 1 0 0 1 1 1 0 Mitochondrial genome maintenance MGM101 VWA PF00092.28 ELR23391.1 - 5.3e-11 43.1 0.5 1.2e-10 42.0 0.5 1.6 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.6 ELR23391.1 - 8.1e-05 23.2 0.2 0.00054 20.6 0.2 2.5 1 0 0 1 1 1 1 von Willebrand factor type A domain IFT57 PF10498.9 ELR23391.1 - 0.0074 15.3 0.7 0.0074 15.3 0.7 2.0 2 0 0 2 2 2 1 Intra-flagellar transport protein 57 DCX PF03607.17 ELR23391.1 - 0.014 15.5 0.0 0.09 12.9 0.0 2.4 2 0 0 2 2 2 0 Doublecortin KHA PF11834.8 ELR23391.1 - 0.038 14.1 0.0 0.091 12.9 0.0 1.7 1 0 0 1 1 1 0 KHA, dimerisation domain of potassium ion channel tRNA-synt_1b PF00579.25 ELR23392.1 - 2.3e-54 184.7 0.0 3.3e-54 184.2 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) tRNA_bind PF01588.20 ELR23392.1 - 1.3e-27 95.7 0.4 2.7e-27 94.7 0.4 1.5 1 0 0 1 1 1 1 Putative tRNA binding domain Pur_DNA_glyco PF02245.16 ELR23393.1 - 0.0012 18.3 0.1 0.003 17.0 0.1 1.7 1 1 0 1 1 1 1 Methylpurine-DNA glycosylase (MPG) SR-25 PF10500.9 ELR23393.1 - 0.025 14.2 13.9 0.12 12.0 8.3 2.2 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein CPSF100_C PF13299.6 ELR23393.1 - 2.7 8.2 12.3 11 6.2 0.1 2.4 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal UPF0524 PF15823.5 ELR23393.1 - 3.4 7.0 4.8 1.7 8.0 1.6 2.0 2 0 0 2 2 2 0 UPF0524 of C3orf70 FRG1 PF06229.12 ELR23394.1 - 1.3e-15 57.6 0.1 9.9e-06 25.4 0.0 3.0 1 1 0 2 2 2 2 FRG1-like domain Fascin PF06268.13 ELR23394.1 - 7.9e-15 55.0 0.1 1.7e-12 47.5 0.0 2.0 1 1 1 2 2 2 2 Fascin domain FGF PF00167.18 ELR23394.1 - 1.3e-05 25.3 0.0 0.00012 22.2 0.0 1.9 1 1 1 2 2 2 1 Fibroblast growth factor DUF569 PF04601.13 ELR23394.1 - 4.9e-05 23.0 0.0 0.00077 19.2 0.0 2.1 1 1 0 1 1 1 1 Domain of unknown function (DUF569) IL8 PF00048.20 ELR23394.1 - 0.018 15.2 0.0 2.6 8.2 0.0 2.2 2 0 0 2 2 2 0 Small cytokines (intecrine/chemokine), interleukin-8 like DAGAT PF03982.13 ELR23395.1 - 9.8e-44 149.4 0.5 3.7e-23 81.9 0.1 2.0 2 0 0 2 2 2 2 Diacylglycerol acyltransferase CM_2 PF01817.21 ELR23397.1 - 5.6e-08 33.0 0.0 1.4e-07 31.7 0.0 1.7 2 0 0 2 2 2 1 Chorismate mutase type II DUF4407 PF14362.6 ELR23397.1 - 0.016 14.6 0.4 0.019 14.3 0.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) HalX PF08663.10 ELR23397.1 - 0.085 13.2 0.3 0.26 11.6 0.0 2.0 2 0 0 2 2 2 0 HalX domain Baculo_PEP_C PF04513.12 ELR23397.1 - 0.1 12.6 5.9 0.22 11.5 5.9 1.6 1 1 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus Carn_acyltransf PF00755.20 ELR23398.1 - 2.3e-53 181.7 0.0 3.4e-53 181.2 0.0 1.3 1 1 0 1 1 1 1 Choline/Carnitine o-acyltransferase BRK PF07533.16 ELR23398.1 - 0.36 10.5 1.0 4.2 7.1 0.2 2.5 2 0 0 2 2 2 0 BRK domain PseudoU_synth_2 PF00849.22 ELR23399.1 - 1.4e-19 70.7 0.0 2.5e-19 69.9 0.0 1.4 1 0 0 1 1 1 1 RNA pseudouridylate synthase QslA_E PF18226.1 ELR23399.1 - 0.071 13.0 0.0 0.14 12.1 0.0 1.5 1 0 0 1 1 1 0 LasR-specific antiactivator QslA chain E CAP_C PF08603.11 ELR23400.1 - 1.7e-06 27.7 0.0 2.6e-06 27.1 0.0 1.4 1 0 0 1 1 1 1 Adenylate cyclase associated (CAP) C terminal SEC-C PF02810.15 ELR23400.1 - 0.0028 17.5 9.8 0.0028 17.5 9.8 2.4 2 1 0 2 2 2 1 SEC-C motif DUF5053 PF16476.5 ELR23400.1 - 0.0034 17.0 0.2 0.02 14.5 0.2 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF5053) Sigma54_activ_2 PF14532.6 ELR23400.1 - 0.11 12.6 0.0 0.33 11.0 0.0 1.7 2 0 0 2 2 2 0 Sigma-54 interaction domain Lipase_3 PF01764.25 ELR23401.1 - 1.1e-19 70.7 0.0 4e-19 68.9 0.0 1.9 2 0 0 2 2 2 1 Lipase (class 3) PGAP1 PF07819.13 ELR23402.1 - 1.5e-54 185.2 0.1 2e-54 184.8 0.1 1.2 1 0 0 1 1 1 1 PGAP1-like protein Palm_thioest PF02089.15 ELR23402.1 - 4.6e-05 23.4 0.3 6.9e-05 22.8 0.3 1.2 1 0 0 1 1 1 1 Palmitoyl protein thioesterase Abhydrolase_1 PF00561.20 ELR23402.1 - 0.00016 21.4 0.1 0.00031 20.5 0.1 1.5 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 ELR23402.1 - 0.00049 20.8 3.3 0.00049 20.8 3.3 3.5 1 1 0 2 2 2 1 Alpha/beta hydrolase family DUF676 PF05057.14 ELR23402.1 - 0.014 14.9 0.1 0.023 14.2 0.1 1.2 1 0 0 1 1 1 0 Putative serine esterase (DUF676) LCAT PF02450.15 ELR23402.1 - 0.022 13.9 0.1 0.068 12.3 0.0 1.6 2 0 0 2 2 2 0 Lecithin:cholesterol acyltransferase Lipase_2 PF01674.18 ELR23402.1 - 0.036 13.6 0.0 0.081 12.4 0.0 1.4 2 0 0 2 2 2 0 Lipase (class 2) Ycf1 PF05758.12 ELR23402.1 - 0.044 11.7 0.0 0.064 11.1 0.0 1.1 1 0 0 1 1 1 0 Ycf1 Hydrolase_4 PF12146.8 ELR23402.1 - 0.055 12.7 1.1 0.25 10.6 0.1 2.5 2 0 0 2 2 2 0 Serine aminopeptidase, S33 Chlorophyllase2 PF12740.7 ELR23402.1 - 0.068 12.1 0.2 0.19 10.6 0.1 1.8 2 1 0 2 2 2 0 Chlorophyllase enzyme DUF915 PF06028.11 ELR23402.1 - 0.23 10.8 0.0 4.7 6.5 0.0 2.1 2 0 0 2 2 2 0 Alpha/beta hydrolase of unknown function (DUF915) TNFR_16_TM PF18422.1 ELR23402.1 - 0.25 11.4 1.2 1.4 8.9 0.2 2.6 3 0 0 3 3 3 0 Tumor necrosis factor receptor member 16 trans-membrane domain TMEM154 PF15102.6 ELR23403.1 - 0.088 12.7 0.0 0.18 11.7 0.0 1.4 1 0 0 1 1 1 0 TMEM154 protein family Ank_2 PF12796.7 ELR23404.1 - 2.4e-115 377.3 16.3 6.4e-13 49.1 0.2 13.3 5 3 7 13 13 13 12 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ELR23404.1 - 9.8e-105 341.7 16.6 8.5e-08 32.6 0.0 18.9 9 6 10 20 20 20 19 Ankyrin repeats (many copies) Ank_5 PF13857.6 ELR23404.1 - 1.5e-87 286.5 21.8 2e-07 31.1 0.1 19.4 10 7 12 22 22 22 19 Ankyrin repeats (many copies) Ank_3 PF13606.6 ELR23404.1 - 2.3e-78 248.7 14.3 0.0013 19.0 0.0 25.1 26 0 0 26 26 26 14 Ankyrin repeat Ank PF00023.30 ELR23404.1 - 5.5e-66 216.3 15.5 0.0016 18.8 0.0 24.1 25 1 0 25 25 25 13 Ankyrin repeat SPRY PF00622.28 ELR23404.1 - 6.7e-08 32.7 0.2 3.1e-07 30.5 0.2 2.1 1 1 0 1 1 1 1 SPRY domain BRCT PF00533.26 ELR23404.1 - 0.027 14.8 0.0 4 7.9 0.0 3.1 2 0 0 2 2 2 0 BRCA1 C Terminus (BRCT) domain Ad_Cy_reg PF16701.5 ELR23404.1 - 0.1 12.4 0.0 12 5.5 0.0 4.5 5 1 1 6 6 6 0 Adenylate cyclase regulatory domain MBT PF02820.18 ELR23404.1 - 0.18 12.2 0.0 0.65 10.4 0.0 2.0 1 0 0 1 1 1 0 mbt repeat CAP PF00188.26 ELR23405.1 - 2.8e-18 67.0 6.0 5.9e-18 65.9 6.0 1.5 1 0 0 1 1 1 1 Cysteine-rich secretory protein family Mito_carr PF00153.27 ELR23406.1 - 1.2e-66 220.7 0.6 8e-27 93.0 0.0 4.0 3 1 1 4 4 4 4 Mitochondrial carrier protein PhoLip_ATPase_C PF16212.5 ELR23407.1 - 1.2e-82 277.5 18.9 1.2e-82 277.5 18.9 2.1 2 0 0 2 2 2 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 ELR23407.1 - 3.6e-24 84.2 0.0 1.2e-23 82.6 0.0 1.9 1 0 0 1 1 1 1 Phospholipid-translocating ATPase N-terminal Cation_ATPase PF13246.6 ELR23407.1 - 3.5e-15 55.8 0.0 2.6e-14 53.1 0.0 2.5 3 0 0 3 3 3 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 ELR23407.1 - 2.8e-12 47.4 0.5 1.4e-05 25.5 0.1 3.3 3 0 0 3 3 3 3 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.20 ELR23407.1 - 2.9e-08 33.5 0.0 2e-07 30.7 0.0 2.5 3 1 0 3 3 3 1 E1-E2 ATPase Hydrolase_3 PF08282.12 ELR23407.1 - 0.046 13.4 0.0 0.2 11.4 0.0 2.0 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase DUF3040 PF11239.8 ELR23407.1 - 5.5 7.3 7.3 8.4 6.7 0.3 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF3040) Glycos_transf_1 PF00534.20 ELR23408.1 - 1.3e-06 28.1 0.0 2.5e-06 27.1 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 ELR23408.1 - 0.00081 19.8 0.0 0.0028 18.1 0.0 2.0 2 1 0 2 2 2 1 Glycosyl transferases group 1 Methyltransf_16 PF10294.9 ELR23411.1 - 1e-18 67.6 0.0 9.6e-15 54.7 0.0 2.1 2 0 0 2 2 2 2 Lysine methyltransferase Methyltransf_25 PF13649.6 ELR23411.1 - 0.0052 17.5 0.0 0.018 15.7 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain MTS PF05175.14 ELR23411.1 - 0.0083 15.7 0.0 0.012 15.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_11 PF08241.12 ELR23411.1 - 0.051 14.2 0.0 0.1 13.2 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain DREV PF05219.12 ELR23411.1 - 0.13 11.3 0.0 0.2 10.7 0.0 1.2 1 0 0 1 1 1 0 DREV methyltransferase OHCU_decarbox PF09349.10 ELR23412.1 - 1.5e-35 123.0 0.0 1.7e-35 122.8 0.0 1.0 1 0 0 1 1 1 1 OHCU decarboxylase Glycos_transf_1 PF00534.20 ELR23413.1 - 8.3e-07 28.7 0.0 1.6e-06 27.7 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 ELR23413.1 - 0.00059 20.3 0.0 0.0012 19.3 0.0 1.6 1 1 0 1 1 1 1 Glycosyl transferases group 1 PGDYG PF14083.6 ELR23414.1 - 6.5e-06 26.3 0.0 0.0018 18.5 0.0 2.2 1 1 1 2 2 2 2 PGDYG protein C2 PF00168.30 ELR23415.1 - 4.8e-17 62.1 0.0 1e-16 61.1 0.0 1.6 1 0 0 1 1 1 1 C2 domain SnoaL PF07366.12 ELR23415.1 - 7.4e-12 45.2 0.0 1.6e-11 44.1 0.0 1.5 1 0 0 1 1 1 1 SnoaL-like polyketide cyclase PH PF00169.29 ELR23415.1 - 3.2e-11 43.7 0.1 7.7e-11 42.4 0.1 1.7 1 0 0 1 1 1 1 PH domain SnoaL_2 PF12680.7 ELR23415.1 - 4.9e-08 33.5 0.1 1.9e-07 31.6 0.1 2.1 2 0 0 2 2 2 1 SnoaL-like domain PH_11 PF15413.6 ELR23415.1 - 8.6e-05 22.9 0.4 8.6e-05 22.9 0.4 2.0 2 0 0 2 2 2 1 Pleckstrin homology domain SnoaL_4 PF13577.6 ELR23415.1 - 0.063 13.4 0.0 0.21 11.7 0.0 1.8 1 0 0 1 1 1 0 SnoaL-like domain MMM1 PF10296.9 ELR23415.1 - 0.26 10.3 0.9 1 8.3 0.0 2.1 2 0 0 2 2 2 0 Maintenance of mitochondrial morphology protein 1 YqzE PF14038.6 ELR23415.1 - 2.7 8.0 6.9 8.8 6.4 6.9 1.9 1 0 0 1 1 1 0 YqzE-like protein GDP_Man_Dehyd PF16363.5 ELR23417.1 - 1.7e-54 185.5 0.0 8.5e-54 183.2 0.0 1.8 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 ELR23417.1 - 3.1e-45 154.5 0.0 3.9e-45 154.2 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.12 ELR23417.1 - 3.1e-13 49.5 0.0 3.3e-08 33.0 0.0 2.2 2 0 0 2 2 2 2 Male sterility protein 3Beta_HSD PF01073.19 ELR23417.1 - 1.3e-12 47.3 0.0 2e-12 46.7 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Polysacc_synt_2 PF02719.15 ELR23417.1 - 3.5e-11 42.8 0.0 3.6e-06 26.3 0.0 2.7 2 1 0 2 2 2 2 Polysaccharide biosynthesis protein RmlD_sub_bind PF04321.17 ELR23417.1 - 2.3e-05 23.7 0.0 3.2e-05 23.2 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain adh_short PF00106.25 ELR23417.1 - 0.036 13.5 0.0 0.13 11.7 0.0 1.9 2 0 0 2 2 2 0 short chain dehydrogenase Ras PF00071.22 ELR23419.1 - 1.3e-35 122.4 0.0 1.4e-35 122.3 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR23419.1 - 5e-11 42.9 0.0 8.2e-11 42.2 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR23419.1 - 0.007 15.8 0.0 0.0088 15.5 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family TPR_2 PF07719.17 ELR23420.1 - 0.0038 17.2 31.7 0.76 10.0 0.0 9.4 11 0 0 11 11 11 2 Tetratricopeptide repeat TPR_12 PF13424.6 ELR23420.1 - 0.0041 17.4 29.1 0.13 12.6 1.8 7.8 8 0 0 8 8 8 2 Tetratricopeptide repeat SRP_TPR_like PF17004.5 ELR23420.1 - 0.012 15.7 0.2 6.4 6.8 0.0 2.9 3 0 0 3 3 3 0 Putative TPR-like repeat TPR_19 PF14559.6 ELR23420.1 - 0.039 14.5 29.3 2.9 8.5 0.1 7.7 8 1 0 8 8 8 0 Tetratricopeptide repeat TPR_8 PF13181.6 ELR23420.1 - 0.052 13.8 5.4 4 7.9 0.9 4.8 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_14 PF13428.6 ELR23420.1 - 0.067 14.0 28.9 1.6 9.8 0.0 8.6 9 1 1 10 10 10 0 Tetratricopeptide repeat TPR_16 PF13432.6 ELR23420.1 - 0.1 13.3 0.1 0.1 13.3 0.1 8.3 8 1 1 9 9 9 0 Tetratricopeptide repeat TPR_9 PF13371.6 ELR23420.1 - 2.4 8.4 9.1 4.5 7.5 0.3 5.2 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_10 PF13374.6 ELR23420.1 - 8.6 6.4 13.0 17 5.5 0.2 6.0 7 0 0 7 7 7 0 Tetratricopeptide repeat RVT_2 PF07727.14 ELR23424.1 - 5.1e-46 157.3 0.0 7.6e-46 156.7 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Retrotran_gag_2 PF14223.6 ELR23424.1 - 1.5e-08 34.4 0.0 6.1e-08 32.4 0.0 1.9 2 0 0 2 2 2 1 gag-polypeptide of LTR copia-type gag_pre-integrs PF13976.6 ELR23424.1 - 6.7e-07 29.1 0.0 8.1e-06 25.6 0.0 2.8 3 0 0 3 3 3 1 GAG-pre-integrase domain zf-C2H2_10 PF16588.5 ELR23424.1 - 0.00038 20.1 3.9 0.00074 19.2 3.9 1.4 1 0 0 1 1 1 1 C2H2 zinc-finger Arm-DNA-bind_3 PF13356.6 ELR23424.1 - 0.12 12.8 0.1 5 7.6 0.1 2.7 2 0 0 2 2 2 0 Arm DNA-binding domain DUF4448 PF14610.6 ELR23426.1 - 0.14 11.9 0.2 0.34 10.7 0.1 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF4448) SKG6 PF08693.10 ELR23426.1 - 2.3 7.7 21.6 29 4.2 21.6 2.3 1 1 0 1 1 1 0 Transmembrane alpha-helix domain ADH_zinc_N PF00107.26 ELR23427.1 - 9.3e-12 45.1 0.0 1.6e-11 44.3 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 ELR23427.1 - 1.8e-05 24.6 0.0 3.7e-05 23.6 0.0 1.6 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.6 ELR23427.1 - 0.00012 23.1 0.0 0.00023 22.2 0.0 1.5 1 1 0 1 1 1 1 Zinc-binding dehydrogenase CoA_binding_2 PF13380.6 ELR23427.1 - 0.0021 18.5 0.0 0.014 15.9 0.0 2.3 2 1 1 3 3 3 1 CoA binding domain ADH_N_2 PF16884.5 ELR23427.1 - 0.035 14.0 0.2 0.16 11.9 0.1 2.1 2 1 0 2 2 2 0 N-terminal domain of oxidoreductase Glyoxalase PF00903.25 ELR23428.1 - 3.9e-10 40.0 3.4 4.7e-10 39.8 0.0 2.3 2 0 0 2 2 2 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_2 PF12681.7 ELR23428.1 - 3.5e-06 26.9 0.0 2.2e-05 24.3 0.0 2.2 2 0 0 2 2 2 1 Glyoxalase-like domain Glyoxalase_6 PF18029.1 ELR23428.1 - 0.00022 22.0 0.3 0.00022 22.0 0.3 2.5 2 2 0 2 2 2 1 Glyoxalase-like domain STATa_Ig PF18214.1 ELR23429.1 - 3.4e-46 156.2 0.5 6e-46 155.4 0.5 1.4 1 0 0 1 1 1 1 STATa Immunoglobulin-like domain EF-hand_12 PF17901.1 ELR23429.1 - 2.3e-42 143.3 4.5 3.7e-42 142.7 2.1 2.3 2 0 0 2 2 2 1 EF-hand fold domain Dict-STAT-coil PF09267.10 ELR23429.1 - 1.9e-13 50.8 7.3 4.4e-13 49.6 7.3 1.6 1 0 0 1 1 1 1 Dictyostelium STAT, coiled coil SH2 PF00017.24 ELR23429.1 - 2.4e-08 34.0 0.0 7.6e-08 32.3 0.0 1.8 1 0 0 1 1 1 1 SH2 domain TFIIA PF03153.13 ELR23429.1 - 0.028 14.4 24.0 0.042 13.9 24.0 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit SR-25 PF10500.9 ELR23429.1 - 2.2 7.8 9.5 4.2 6.9 9.5 1.4 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein RhoGEF PF00621.20 ELR23430.1 - 4e-31 108.7 0.8 5.4e-30 105.0 0.8 2.5 1 1 0 1 1 1 1 RhoGEF domain PH PF00169.29 ELR23430.1 - 5.4e-05 23.6 0.0 0.00017 22.1 0.0 1.8 1 0 0 1 1 1 1 PH domain PH_10 PF15411.6 ELR23430.1 - 0.0029 17.9 0.9 0.0092 16.2 0.0 2.2 2 0 0 2 2 2 1 Pleckstrin homology domain RRM_1 PF00076.22 ELR23430.1 - 0.2 11.5 0.1 0.93 9.4 0.1 2.1 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) IQ PF00612.27 ELR23430.1 - 0.38 10.7 2.4 1 9.3 2.4 1.8 1 0 0 1 1 1 0 IQ calmodulin-binding motif WD-3 PF09765.9 ELR23431.1 - 5.7e-68 229.3 0.0 7.9e-68 228.9 0.0 1.1 1 0 0 1 1 1 1 WD-repeat region FANCL_C PF11793.8 ELR23431.1 - 2.6e-25 88.4 1.5 4.6e-25 87.6 1.5 1.4 1 0 0 1 1 1 1 FANCL C-terminal domain zf-RING_2 PF13639.6 ELR23431.1 - 2.3e-05 24.6 3.0 5.1e-05 23.5 3.0 1.7 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.7 ELR23431.1 - 0.0018 18.5 1.4 0.0047 17.2 1.4 1.7 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 ELR23431.1 - 0.0044 17.0 2.7 0.0093 16.0 1.6 2.1 2 1 0 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger PHD PF00628.29 ELR23431.1 - 0.023 14.6 1.5 0.042 13.8 1.5 1.5 1 0 0 1 1 1 0 PHD-finger zf-HC5HC2H PF13771.6 ELR23431.1 - 0.057 13.7 0.8 0.1 12.9 0.8 1.4 1 0 0 1 1 1 0 PHD-like zinc-binding domain RINGv PF12906.7 ELR23431.1 - 0.12 12.5 1.7 0.23 11.6 1.7 1.5 1 0 0 1 1 1 0 RING-variant domain zf-RING-like PF08746.11 ELR23431.1 - 0.27 11.6 1.9 0.56 10.6 1.9 1.6 1 0 0 1 1 1 0 RING-like domain Ank_4 PF13637.6 ELR23432.1 - 4.1e-06 27.2 0.0 0.0079 16.8 0.0 2.7 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 ELR23432.1 - 6.5e-06 26.3 0.0 1.3e-05 25.4 0.0 1.5 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 ELR23432.1 - 8e-06 26.4 0.0 1.9e-05 25.2 0.0 1.6 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.30 ELR23432.1 - 1.2e-05 25.6 2.2 6.6e-05 23.2 0.2 2.8 2 1 1 3 3 3 1 Ankyrin repeat Ank_3 PF13606.6 ELR23432.1 - 0.0008 19.7 0.1 0.0033 17.8 0.0 2.1 2 0 0 2 2 2 1 Ankyrin repeat Hamartin PF04388.12 ELR23432.1 - 0.25 10.0 24.6 0.36 9.4 24.6 1.1 1 0 0 1 1 1 0 Hamartin protein SOG2 PF10428.9 ELR23432.1 - 0.25 10.5 24.3 0.45 9.7 24.3 1.5 1 0 0 1 1 1 0 RAM signalling pathway protein Lectin_leg-like PF03388.13 ELR23433.1 - 3.9e-55 186.7 0.1 5.8e-55 186.1 0.1 1.1 1 0 0 1 1 1 1 Legume-like lectin family Bact_lectin PF18483.1 ELR23433.1 - 1.8e-14 54.2 0.2 2.8e-14 53.6 0.2 1.1 1 0 0 1 1 1 1 Bacterial lectin Lectin_legB PF00139.19 ELR23433.1 - 1.5e-05 24.7 0.0 0.12 11.9 0.0 2.2 2 0 0 2 2 2 2 Legume lectin domain DUF2046 PF09755.9 ELR23433.1 - 0.04 13.2 0.4 0.057 12.6 0.4 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein H4 (DUF2046) OmpH PF03938.14 ELR23433.1 - 0.078 13.3 0.0 0.12 12.7 0.0 1.2 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) Baculo_PEP_C PF04513.12 ELR23433.1 - 0.1 12.6 0.3 0.21 11.6 0.3 1.4 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF1664 PF07889.12 ELR23433.1 - 0.14 12.2 0.5 0.32 11.0 0.5 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) DUF4658 PF15555.6 ELR23433.1 - 0.17 12.0 0.0 0.36 11.0 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4658) HA PF03457.14 ELR23434.1 - 2.2e-25 88.8 9.3 9.1e-14 51.6 0.4 3.0 3 0 0 3 3 3 2 Helicase associated domain LCD1 PF09798.9 ELR23435.1 - 0.3 9.5 6.9 0.38 9.2 6.9 1.1 1 0 0 1 1 1 0 DNA damage checkpoint protein Piezo_RRas_bdg PF12166.8 ELR23436.1 - 7.4e-88 295.7 0.1 1.2e-87 294.9 0.1 1.4 1 0 0 1 1 1 1 Piezo non-specific cation channel, R-Ras-binding domain DUF3290 PF11694.8 ELR23436.1 - 1.8 8.5 4.7 0.85 9.6 0.5 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3290) Sec8_exocyst PF04048.14 ELR23437.1 - 0.073 13.0 0.0 0.13 12.2 0.0 1.3 1 0 0 1 1 1 0 Sec8 exocyst complex component specific domain DnaJ_C PF01556.18 ELR23438.1 - 3.2e-41 140.9 0.2 4.5e-41 140.4 0.2 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 ELR23438.1 - 3.3e-27 94.4 2.9 3.3e-27 94.4 2.9 1.9 2 0 0 2 2 2 1 DnaJ domain Atg14 PF10186.9 ELR23438.1 - 0.0048 16.0 3.9 0.0087 15.2 3.9 1.3 1 0 0 1 1 1 1 Vacuolar sorting 38 and autophagy-related subunit 14 Exonuc_VII_L PF02601.15 ELR23438.1 - 0.005 16.5 4.3 0.0078 15.8 4.3 1.3 1 0 0 1 1 1 1 Exonuclease VII, large subunit HalX PF08663.10 ELR23438.1 - 0.0072 16.6 0.1 0.018 15.4 0.1 1.7 1 0 0 1 1 1 1 HalX domain Thioesterase PF00975.20 ELR23438.1 - 0.019 15.1 0.9 0.032 14.3 0.9 1.3 1 0 0 1 1 1 0 Thioesterase domain BLOC1S3 PF15753.5 ELR23438.1 - 0.021 15.0 2.2 0.04 14.1 2.2 1.4 1 0 0 1 1 1 0 Biogenesis of lysosome-related organelles complex 1 subunit 3 SKA1 PF07160.12 ELR23438.1 - 0.022 14.6 2.1 0.057 13.3 2.1 1.6 1 0 0 1 1 1 0 Spindle and kinetochore-associated protein 1 GRP PF07172.11 ELR23438.1 - 0.023 15.3 9.4 0.023 15.3 9.4 2.5 2 0 0 2 2 1 0 Glycine rich protein family Enkurin PF13864.6 ELR23438.1 - 0.14 12.6 0.3 0.14 12.6 0.3 2.4 2 1 0 2 2 2 0 Calmodulin-binding TetR_C_20 PF17925.1 ELR23438.1 - 0.25 11.7 3.2 0.62 10.4 3.2 1.6 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain TBCA PF02970.16 ELR23438.1 - 0.6 10.5 7.0 0.056 13.8 2.1 1.8 2 0 0 2 2 2 0 Tubulin binding cofactor A DUF4140 PF13600.6 ELR23438.1 - 0.72 10.3 4.8 1.5 9.3 0.1 2.9 1 1 1 2 2 2 0 N-terminal domain of unknown function (DUF4140) Alanine_zipper PF11839.8 ELR23438.1 - 1.9 8.9 14.6 0.27 11.6 7.4 2.5 2 0 0 2 2 2 0 Alanine-zipper, major outer membrane lipoprotein NAD_binding_4 PF07993.12 ELR23439.1 - 2.9e-54 183.9 0.0 9.3e-50 169.2 0.0 2.2 2 0 0 2 2 2 2 Male sterility protein Sterile PF03015.19 ELR23439.1 - 7.2e-19 67.8 0.0 1.2e-18 67.1 0.0 1.4 1 0 0 1 1 1 1 Male sterility protein Epimerase PF01370.21 ELR23439.1 - 0.0021 17.5 0.6 0.59 9.5 0.1 3.1 2 1 0 2 2 2 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.17 ELR23439.1 - 0.058 12.5 0.0 0.9 8.6 0.0 2.1 2 0 0 2 2 2 0 RmlD substrate binding domain Ran_BP1 PF00638.18 ELR23440.1 - 2.7e-19 69.6 0.1 2.7e-19 69.6 0.1 1.7 2 0 0 2 2 2 1 RanBP1 domain DUF1738 PF08401.11 ELR23440.1 - 1.8 8.7 7.4 7 6.8 0.0 3.1 2 1 0 2 2 2 0 Domain of unknown function (DUF1738) PLDc_2 PF13091.6 ELR23441.1 - 9.7e-15 54.6 0.0 3.9e-09 36.5 0.0 2.6 2 0 0 2 2 2 2 PLD-like domain PLDc PF00614.22 ELR23441.1 - 4.2e-14 52.0 8.0 4.3e-09 36.2 0.4 2.9 3 0 0 3 3 3 2 Phospholipase D Active site motif Pkinase PF00069.25 ELR23441.1 - 8.8e-12 44.9 0.0 1.8e-11 43.9 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR23441.1 - 6e-09 35.6 0.2 1.8e-08 34.0 0.2 1.7 1 1 0 1 1 1 1 Protein tyrosine kinase SH2 PF00017.24 ELR23441.1 - 7.5e-07 29.2 0.0 1.9e-06 27.8 0.0 1.6 1 0 0 1 1 1 1 SH2 domain Ras PF00071.22 ELR23442.1 - 8.9e-34 116.4 0.2 1.1e-33 116.1 0.2 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR23442.1 - 2.3e-26 92.4 0.1 3.1e-26 91.9 0.1 1.1 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR23442.1 - 9.1e-08 31.8 0.0 1.3e-07 31.2 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 ELR23442.1 - 8e-05 22.7 0.0 0.00012 22.1 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 ELR23442.1 - 0.00074 18.9 0.1 0.00094 18.6 0.1 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region PduV-EutP PF10662.9 ELR23442.1 - 0.00086 19.1 0.1 0.0013 18.5 0.1 1.2 1 0 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation AAA_33 PF13671.6 ELR23442.1 - 0.0032 17.6 0.0 0.005 17.0 0.0 1.3 1 0 0 1 1 1 1 AAA domain RsgA_GTPase PF03193.16 ELR23442.1 - 0.0077 16.2 0.2 0.012 15.5 0.2 1.3 1 0 0 1 1 1 1 RsgA GTPase AAA_22 PF13401.6 ELR23442.1 - 0.0082 16.4 0.0 0.012 15.8 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 ELR23442.1 - 0.012 15.9 0.1 0.017 15.5 0.1 1.6 1 1 0 1 1 1 0 AAA ATPase domain AAA_5 PF07728.14 ELR23442.1 - 0.013 15.5 0.0 0.029 14.4 0.0 1.7 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_7 PF12775.7 ELR23442.1 - 0.014 14.9 0.2 0.02 14.4 0.2 1.2 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_24 PF13479.6 ELR23442.1 - 0.02 14.7 0.0 0.027 14.2 0.0 1.2 1 0 0 1 1 1 0 AAA domain NB-ARC PF00931.22 ELR23442.1 - 0.036 13.3 0.0 0.052 12.7 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain NACHT PF05729.12 ELR23442.1 - 0.047 13.6 0.1 0.17 11.8 0.0 1.8 2 0 0 2 2 2 0 NACHT domain AAA PF00004.29 ELR23442.1 - 0.05 14.0 0.0 0.067 13.6 0.0 1.2 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) SRPRB PF09439.10 ELR23442.1 - 0.11 12.0 0.0 0.15 11.5 0.0 1.2 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit DAP3 PF10236.9 ELR23442.1 - 0.12 11.6 0.1 0.16 11.1 0.1 1.1 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 GTP_EFTU PF00009.27 ELR23442.1 - 0.13 11.8 0.1 2.8 7.4 0.0 2.0 1 1 1 2 2 2 0 Elongation factor Tu GTP binding domain ATPase_2 PF01637.18 ELR23442.1 - 0.13 12.1 0.0 0.18 11.7 0.0 1.1 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea zf-C3Hc3H PF13891.6 ELR23444.1 - 0.16 12.4 4.0 1.4 9.4 0.3 2.2 1 1 1 2 2 2 0 Potential DNA-binding domain SDA1 PF05285.12 ELR23444.1 - 6.3 6.1 29.3 7.5 5.9 29.3 1.2 1 0 0 1 1 1 0 SDA1 CDC45 PF02724.14 ELR23444.1 - 7.9 4.6 22.2 8.2 4.6 22.2 1.1 1 0 0 1 1 1 0 CDC45-like protein GRAM PF02893.20 ELR23445.1 - 4.4e-20 71.7 0.0 1.6e-13 50.5 0.1 2.9 2 1 0 2 2 2 2 GRAM domain RabGAP-TBC PF00566.18 ELR23446.1 - 5.2e-49 166.8 0.6 1.2e-48 165.7 0.6 1.6 1 0 0 1 1 1 1 Rab-GTPase-TBC domain NAD2 PF18782.1 ELR23446.1 - 0.025 14.7 0.1 0.048 13.8 0.1 1.4 1 0 0 1 1 1 0 Novel AID APOBEC clade 2 Suv3_N PF18114.1 ELR23446.1 - 0.038 14.1 0.1 0.12 12.5 0.0 1.8 2 0 0 2 2 2 0 Suv3 helical N-terminal domain EF-hand_6 PF13405.6 ELR23446.1 - 0.12 12.4 0.1 0.75 9.9 0.0 2.3 2 0 0 2 2 2 0 EF-hand domain EF-hand_1 PF00036.32 ELR23446.1 - 0.2 11.3 0.4 0.71 9.6 0.1 2.1 2 0 0 2 2 2 0 EF hand Nucleoporin_N PF08801.11 ELR23447.1 - 1.9e-73 247.7 0.0 3e-73 247.0 0.0 1.2 1 0 0 1 1 1 1 Nup133 N terminal like Nucleoporin_C PF03177.14 ELR23447.1 - 1.8e-15 56.8 1.6 7e-14 51.5 0.6 2.7 2 1 0 2 2 2 2 Non-repetitive/WGA-negative nucleoporin C-terminal Sec5 PF15469.6 ELR23448.1 - 1.6e-33 116.1 0.0 3.3e-33 115.1 0.0 1.5 1 0 0 1 1 1 1 Exocyst complex component Sec5 zf-C3HC4_2 PF13923.6 ELR23448.1 - 1.4e-08 34.4 7.7 2.7e-08 33.5 7.7 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 ELR23448.1 - 2.1e-08 34.4 9.3 3.7e-08 33.6 9.3 1.4 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 ELR23448.1 - 3e-08 33.4 7.2 5.3e-08 32.6 7.2 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 ELR23448.1 - 6.1e-07 29.2 6.4 9.7e-07 28.6 6.4 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 ELR23448.1 - 4e-06 27.0 6.8 1.1e-05 25.5 6.8 1.8 1 0 0 1 1 1 1 RING-H2 zinc finger domain CUE PF02845.16 ELR23448.1 - 6.7e-06 25.7 0.0 1.5e-05 24.6 0.0 1.6 1 0 0 1 1 1 1 CUE domain Vps51 PF08700.11 ELR23448.1 - 1e-05 25.5 0.2 4.5e-05 23.5 0.0 2.1 2 0 0 2 2 2 1 Vps51/Vps67 zf-RING_5 PF14634.6 ELR23448.1 - 2.3e-05 24.2 8.2 4.1e-05 23.5 8.2 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 ELR23448.1 - 2.5e-05 24.2 4.6 4.9e-05 23.3 4.6 1.5 1 0 0 1 1 1 1 RING-type zinc-finger Prok-RING_4 PF14447.6 ELR23448.1 - 7.4e-05 22.5 5.2 0.00017 21.4 5.2 1.6 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 COG2 PF06148.11 ELR23448.1 - 0.0044 17.1 0.2 0.066 13.3 0.1 2.4 2 0 0 2 2 2 1 COG (conserved oligomeric Golgi) complex component, COG2 zf-RING_6 PF14835.6 ELR23448.1 - 0.036 13.9 3.0 0.075 12.9 3.0 1.4 1 0 0 1 1 1 0 zf-RING of BARD1-type protein zf-ANAPC11 PF12861.7 ELR23448.1 - 0.048 13.7 5.0 0.12 12.4 5.0 1.6 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger Siva PF05458.12 ELR23448.1 - 0.11 12.2 1.8 0.25 11.0 1.8 1.5 1 0 0 1 1 1 0 Cd27 binding protein (Siva) zf-RING_4 PF14570.6 ELR23448.1 - 0.14 11.9 7.7 0.3 10.9 7.7 1.6 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-RING_11 PF17123.5 ELR23448.1 - 0.15 11.8 4.7 0.3 10.9 4.7 1.5 1 0 0 1 1 1 0 RING-like zinc finger zf-C3HC4_4 PF15227.6 ELR23448.1 - 0.22 11.7 7.8 0.42 10.8 7.8 1.5 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING Baculo_IE-1 PF05290.11 ELR23448.1 - 0.49 10.3 2.8 0.95 9.4 2.8 1.3 1 0 0 1 1 1 0 Baculovirus immediate-early protein (IE-0) zf-RING_10 PF16685.5 ELR23448.1 - 0.6 10.3 4.7 1.2 9.3 4.7 1.4 1 0 0 1 1 1 0 zinc RING finger of MSL2 zf-P11 PF03854.14 ELR23448.1 - 1.3 8.8 3.9 2.5 7.8 3.9 1.5 1 0 0 1 1 1 0 P-11 zinc finger DZR PF12773.7 ELR23448.1 - 9.2 6.4 6.3 19 5.3 6.3 1.5 1 0 0 1 1 1 0 Double zinc ribbon Arf PF00025.21 ELR23449.1 - 2.6e-63 212.6 0.0 3e-63 212.4 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family G-alpha PF00503.20 ELR23449.1 - 1.4e-11 44.2 0.1 3e-08 33.2 0.0 2.4 1 1 1 2 2 2 2 G-protein alpha subunit Roc PF08477.13 ELR23449.1 - 7.4e-08 32.6 0.0 1.8e-07 31.4 0.0 1.6 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 ELR23449.1 - 1.4e-07 31.1 0.0 1.9e-07 30.7 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Ras PF00071.22 ELR23449.1 - 2.1e-06 27.5 0.0 2.4e-06 27.2 0.0 1.1 1 0 0 1 1 1 1 Ras family MMR_HSR1 PF01926.23 ELR23449.1 - 4.5e-06 26.7 0.0 6.2e-06 26.3 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 ELR23449.1 - 0.00024 20.5 0.0 0.00031 20.2 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region PduV-EutP PF10662.9 ELR23449.1 - 0.031 14.0 0.0 0.089 12.5 0.0 1.7 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Antibiotic_NAT PF02522.14 ELR23449.1 - 0.21 11.4 0.0 0.27 11.0 0.0 1.1 1 0 0 1 1 1 0 Aminoglycoside 3-N-acetyltransferase JmjN PF02375.17 ELR23449.1 - 0.34 10.9 0.9 0.6 10.1 0.9 1.4 1 0 0 1 1 1 0 jmjN domain UEV PF05743.13 ELR23450.1 - 1.6e-17 63.5 0.0 3.1e-17 62.5 0.0 1.4 1 0 0 1 1 1 1 UEV domain Vps23_core PF09454.10 ELR23450.1 - 1e-14 54.2 1.9 3.8e-14 52.4 1.2 2.3 2 1 0 2 2 2 1 Vps23 core domain Myotub-related PF06602.14 ELR23452.1 - 2.6e-11 43.1 0.2 1.4e-08 34.1 0.0 2.1 1 1 1 2 2 2 2 Myotubularin-like phosphatase domain Myotub-related PF06602.14 ELR23453.1 - 2e-81 273.6 0.0 2.5e-81 273.4 0.0 1.1 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain 3-PAP PF12578.8 ELR23453.1 - 0.015 15.0 0.1 0.033 13.9 0.1 1.5 1 0 0 1 1 1 0 Myotubularin-associated protein Ras PF00071.22 ELR23454.1 - 8.3e-64 214.1 0.7 9.9e-64 213.8 0.7 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR23454.1 - 1.4e-35 122.1 0.2 2e-35 121.6 0.2 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR23454.1 - 2.5e-17 62.9 0.1 2.9e-17 62.7 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 ELR23454.1 - 1.7e-05 24.8 0.1 2.7e-05 24.2 0.1 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 ELR23454.1 - 1.9e-05 24.2 0.2 2.2e-05 23.9 0.2 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 ELR23454.1 - 2e-05 24.6 0.6 0.029 14.3 0.1 2.1 1 1 1 2 2 2 2 RsgA GTPase GTP_EFTU PF00009.27 ELR23454.1 - 4.1e-05 23.2 0.3 0.00014 21.5 0.3 1.9 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain SRPRB PF09439.10 ELR23454.1 - 0.00013 21.4 0.1 0.00023 20.7 0.1 1.3 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit AAA_16 PF13191.6 ELR23454.1 - 0.038 14.4 0.0 0.052 13.9 0.0 1.5 1 1 0 1 1 1 0 AAA ATPase domain AAA_29 PF13555.6 ELR23454.1 - 0.05 13.4 0.1 0.19 11.5 0.0 2.0 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA_7 PF12775.7 ELR23454.1 - 0.051 13.1 0.0 0.1 12.1 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region MCM PF00493.23 ELR23454.1 - 0.057 12.5 0.0 0.11 11.6 0.0 1.4 1 0 0 1 1 1 0 MCM P-loop domain AAA_24 PF13479.6 ELR23454.1 - 0.066 12.9 0.0 0.13 12.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain FeoB_N PF02421.18 ELR23454.1 - 0.07 12.7 0.0 0.32 10.5 0.0 1.9 1 1 0 1 1 1 0 Ferrous iron transport protein B TniB PF05621.11 ELR23454.1 - 0.16 11.4 0.0 0.28 10.6 0.0 1.5 1 0 0 1 1 1 0 Bacterial TniB protein RRM_1 PF00076.22 ELR23455.1 - 1.4e-23 82.5 0.1 1.1e-12 47.5 0.1 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 ELR23455.1 - 7.9e-06 25.5 0.0 0.00072 19.2 0.0 2.1 1 1 1 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DbpA PF03880.15 ELR23455.1 - 0.00013 21.9 0.0 0.52 10.4 0.0 2.2 2 0 0 2 2 2 2 DbpA RNA binding domain RNA_bind PF08675.11 ELR23455.1 - 0.11 12.6 0.0 0.24 11.5 0.0 1.5 2 0 0 2 2 2 0 RNA binding domain CDC45 PF02724.14 ELR23455.1 - 8.7 4.5 8.2 10 4.2 8.2 1.2 1 0 0 1 1 1 0 CDC45-like protein GIT_CC PF16559.5 ELR23456.1 - 0.011 15.6 1.1 0.019 14.8 1.1 1.3 1 0 0 1 1 1 0 GIT coiled-coil Rho guanine nucleotide exchange factor PAS_9 PF13426.7 ELR23456.1 - 0.022 15.0 0.0 0.041 14.2 0.0 1.4 1 0 0 1 1 1 0 PAS domain PAS_4 PF08448.10 ELR23456.1 - 0.029 14.6 0.0 0.11 12.7 0.0 2.0 1 0 0 1 1 1 0 PAS fold PAS PF00989.25 ELR23456.1 - 0.052 13.6 0.9 0.23 11.4 0.0 2.5 2 1 0 2 2 2 0 PAS fold PAS_8 PF13188.7 ELR23456.1 - 0.16 12.1 0.0 0.38 10.8 0.0 1.6 1 0 0 1 1 1 0 PAS domain Adaptin_binding PF10199.9 ELR23456.1 - 0.37 11.4 15.1 1.2 9.7 15.1 1.9 1 1 0 1 1 1 0 Alpha and gamma adaptin binding protein p34 FAM199X PF15814.5 ELR23456.1 - 1.3 8.1 5.3 2.9 6.9 5.3 1.6 1 0 0 1 1 1 0 Protein family FAM199X RskA PF10099.9 ELR23457.1 - 0.0066 16.8 3.3 0.0066 16.8 3.3 2.0 1 1 1 2 2 2 1 Anti-sigma-K factor rskA Acetyltransf_13 PF13880.6 ELR23458.1 - 3.3e-31 107.1 0.0 6.1e-31 106.2 0.0 1.5 1 0 0 1 1 1 1 ESCO1/2 acetyl-transferase Acetyltransf_1 PF00583.25 ELR23458.1 - 3.1e-05 24.2 0.0 4.7e-05 23.6 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 ELR23458.1 - 4.1e-05 23.9 0.0 7.5e-05 23.1 0.0 1.6 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 ELR23458.1 - 0.0018 18.2 0.0 0.0032 17.4 0.0 1.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 ELR23458.1 - 0.0097 16.0 0.2 0.18 11.9 0.0 2.3 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_16 PF05301.11 ELR23458.1 - 0.033 14.0 0.0 0.047 13.4 0.0 1.2 1 0 0 1 1 1 0 GNAT acetyltransferase, Mec-17 Acetyltransf_CG PF14542.6 ELR23458.1 - 0.078 13.1 0.0 0.13 12.4 0.0 1.3 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase DNA_pol_phi PF04931.13 ELR23460.1 - 2.3 6.2 4.5 3.3 5.7 4.5 1.1 1 0 0 1 1 1 0 DNA polymerase phi UPF0121 PF03661.13 ELR23461.1 - 1.4e-29 103.2 8.4 1.8e-29 102.8 8.4 1.1 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0121) DUF1180 PF06679.12 ELR23461.1 - 0.56 10.6 3.0 1.1 9.7 3.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) RWP-RK PF02042.15 ELR23462.1 - 0.00057 19.8 0.0 0.0014 18.6 0.0 1.7 1 0 0 1 1 1 1 RWP-RK domain Sel1 PF08238.12 ELR23463.1 - 4.8e-05 23.9 0.1 0.28 11.9 0.0 2.5 2 0 0 2 2 2 2 Sel1 repeat SLC12 PF03522.15 ELR23463.1 - 0.026 13.6 11.4 0.036 13.1 11.4 1.4 1 0 0 1 1 1 0 Solute carrier family 12 Nucleo_P87 PF07267.11 ELR23463.1 - 0.25 10.2 18.9 0.39 9.5 18.9 1.3 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 CDC27 PF09507.10 ELR23463.1 - 0.3 10.4 37.0 0.42 9.9 37.0 1.2 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Borrelia_P83 PF05262.11 ELR23463.1 - 0.94 7.9 30.8 1.1 7.6 30.8 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein Asp-B-Hydro_N PF05279.11 ELR23463.1 - 9.6 6.2 26.2 15 5.6 26.2 1.3 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region Carboxyl_trans PF01039.22 ELR23464.1 - 4.2e-157 523.8 0.0 5.7e-157 523.3 0.0 1.1 1 0 0 1 1 1 1 Carboxyl transferase domain ACC_central PF08326.12 ELR23464.1 - 5.7e-143 477.8 0.0 1.1e-100 338.0 0.0 2.0 2 0 0 2 2 2 2 Acetyl-CoA carboxylase, central region CPSase_L_D2 PF02786.17 ELR23464.1 - 1.5e-48 165.1 0.6 2.5e-48 164.4 0.6 1.3 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Biotin_carb_N PF00289.22 ELR23464.1 - 6.3e-28 97.5 0.0 1.5e-27 96.3 0.0 1.7 1 0 0 1 1 1 1 Biotin carboxylase, N-terminal domain Biotin_carb_C PF02785.19 ELR23464.1 - 8.3e-22 77.3 0.0 5.5e-21 74.7 0.0 2.4 3 0 0 3 3 3 1 Biotin carboxylase C-terminal domain Biotin_lipoyl PF00364.22 ELR23464.1 - 3.5e-08 33.2 0.0 8.1e-08 32.0 0.0 1.6 1 0 0 1 1 1 1 Biotin-requiring enzyme ATP-grasp PF02222.22 ELR23464.1 - 9.7e-08 31.8 0.5 1.9e-07 30.8 0.5 1.4 1 0 0 1 1 1 1 ATP-grasp domain ATP-grasp_3 PF02655.14 ELR23464.1 - 2.2e-07 31.0 0.1 4.4e-07 30.1 0.1 1.5 1 0 0 1 1 1 1 ATP-grasp domain Dala_Dala_lig_C PF07478.13 ELR23464.1 - 1.1e-06 28.4 0.1 2.1e-06 27.4 0.1 1.4 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus ATPgrasp_Ter PF15632.6 ELR23464.1 - 0.023 14.4 0.0 0.055 13.2 0.0 1.6 1 0 0 1 1 1 0 ATP-grasp in the biosynthetic pathway with Ter operon Taeniidae_ag PF05596.11 ELR23464.1 - 0.15 12.1 0.4 0.89 9.6 0.0 2.5 4 0 0 4 4 4 0 Taeniidae antigen ATP11 PF06644.11 ELR23466.1 - 0.17 11.7 9.6 0.21 11.4 9.6 1.1 1 0 0 1 1 1 0 ATP11 protein Med19 PF10278.9 ELR23466.1 - 0.38 10.7 12.6 0.51 10.3 12.6 1.3 1 0 0 1 1 1 0 Mediator of RNA pol II transcription subunit 19 FERM_f0 PF16511.5 ELR23467.1 - 0.036 14.4 0.0 0.043 14.1 0.0 1.1 1 0 0 1 1 1 0 N-terminal or F0 domain of Talin-head FERM FERM_N PF09379.10 ELR23467.1 - 0.17 11.9 0.0 0.4 10.7 0.0 1.6 1 1 0 1 1 1 0 FERM N-terminal domain MMtag PF10159.9 ELR23469.1 - 2e-16 60.1 0.7 2e-16 60.1 0.7 3.0 2 1 0 2 2 2 1 Multiple myeloma tumor-associated HD_3 PF13023.6 ELR23470.1 - 8.1e-32 110.4 0.7 4.5e-17 62.5 0.0 2.1 2 0 0 2 2 2 2 HD domain HD_2 PF12917.7 ELR23470.1 - 0.00044 20.1 0.2 0.45 10.3 0.0 2.1 2 0 0 2 2 2 2 HD containing hydrolase-like enzyme Met_10 PF02475.16 ELR23471.1 - 4.2e-65 219.2 0.0 5.7e-65 218.8 0.0 1.2 1 0 0 1 1 1 1 Met-10+ like-protein TRM PF02005.16 ELR23471.1 - 0.00057 19.2 0.0 0.00083 18.6 0.0 1.1 1 0 0 1 1 1 1 N2,N2-dimethylguanosine tRNA methyltransferase MethyltransfD12 PF02086.15 ELR23471.1 - 0.007 16.1 0.0 0.011 15.4 0.0 1.2 1 0 0 1 1 1 1 D12 class N6 adenine-specific DNA methyltransferase Methyltransf_23 PF13489.6 ELR23471.1 - 0.021 14.7 0.0 0.035 14.0 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_25 PF13649.6 ELR23471.1 - 0.06 14.0 0.0 0.13 13.0 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain PrmA PF06325.13 ELR23471.1 - 0.083 12.3 0.0 0.14 11.5 0.0 1.3 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) TMEM135_C_rich PF15982.5 ELR23473.1 - 1.1 9.9 4.6 5.4 7.6 0.3 3.1 3 0 0 3 3 3 0 N-terminal cysteine-rich region of Transmembrane protein 135 Arm PF00514.23 ELR23474.1 - 1.7e-22 78.7 11.9 5.6e-06 26.2 0.0 9.3 8 1 1 9 9 9 6 Armadillo/beta-catenin-like repeat Arm_3 PF16186.5 ELR23474.1 - 2.6e-10 39.7 0.2 4.1e-10 39.1 0.2 1.3 1 0 0 1 1 1 1 Atypical Arm repeat HEAT_EZ PF13513.6 ELR23474.1 - 3.2e-08 33.9 14.1 9.9e-05 22.8 0.1 5.8 5 1 1 6 6 6 2 HEAT-like repeat IBB PF01749.20 ELR23474.1 - 1.5e-07 31.8 0.6 4.9e-07 30.1 0.2 2.0 2 0 0 2 2 2 1 Importin beta binding domain HEAT_2 PF13646.6 ELR23474.1 - 1.3e-06 28.6 0.9 0.0097 16.3 0.0 4.8 3 2 2 5 5 5 1 HEAT repeats HEAT PF02985.22 ELR23474.1 - 1.8e-06 27.7 8.0 9.4 6.8 0.0 7.0 7 0 0 7 7 7 2 HEAT repeat Atx10homo_assoc PF09759.9 ELR23474.1 - 0.014 15.4 0.0 9.3 6.3 0.0 3.8 4 0 0 4 4 4 0 Spinocerebellar ataxia type 10 protein domain RTP1_C1 PF10363.9 ELR23474.1 - 0.088 13.0 0.0 0.35 11.1 0.0 2.1 1 0 0 1 1 1 0 Required for nuclear transport of RNA pol II C-terminus 1 Cation_ATPase_C PF00689.21 ELR23475.1 - 2.9e-43 147.7 5.6 2.9e-43 147.7 5.6 2.2 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus E1-E2_ATPase PF00122.20 ELR23475.1 - 9e-39 132.9 1.5 9e-39 132.9 1.5 3.3 4 0 0 4 4 4 1 E1-E2 ATPase Hydrolase PF00702.26 ELR23475.1 - 1e-19 71.6 0.2 1e-18 68.4 0.2 2.4 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 ELR23475.1 - 1.2e-13 50.9 0.0 2.8e-13 49.7 0.0 1.6 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Cation_ATPase_N PF00690.26 ELR23475.1 - 4.3e-11 42.3 0.1 1.3e-10 40.8 0.1 1.9 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 ELR23475.1 - 4.1e-05 23.4 0.3 0.015 15.0 0.1 2.4 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase BTB PF00651.31 ELR23476.1 - 2e-24 86.0 0.0 3.2e-24 85.3 0.0 1.3 1 0 0 1 1 1 1 BTB/POZ domain Kelch_6 PF13964.6 ELR23476.1 - 1.9e-09 37.5 5.6 0.0006 20.0 0.0 4.8 4 2 0 4 4 4 2 Kelch motif Kelch_3 PF13415.6 ELR23476.1 - 9.5e-05 22.6 6.4 0.2 12.0 0.0 5.3 5 1 1 6 6 6 2 Galactose oxidase, central domain Kelch_5 PF13854.6 ELR23476.1 - 0.00061 19.7 1.0 3.4 7.7 0.5 3.9 3 1 0 3 3 3 2 Kelch motif Kelch_4 PF13418.6 ELR23476.1 - 0.0042 17.1 1.6 0.68 10.0 0.1 3.8 4 0 0 4 4 4 1 Galactose oxidase, central domain Kelch_2 PF07646.15 ELR23476.1 - 0.33 11.0 12.2 1.1 9.4 0.3 4.6 2 2 0 2 2 2 0 Kelch motif PRA1 PF03208.19 ELR23478.1 - 0.011 15.4 10.9 0.013 15.2 5.4 2.1 2 0 0 2 2 2 0 PRA1 family protein CcmD PF04995.14 ELR23478.1 - 1.5 9.0 0.0 1.5 9.0 0.0 3.0 3 0 0 3 3 3 0 Heme exporter protein D (CcmD) CUE PF02845.16 ELR23479.1 - 7.3e-05 22.4 0.0 0.00014 21.5 0.0 1.5 1 0 0 1 1 1 1 CUE domain TFIIA PF03153.13 ELR23479.1 - 0.0089 16.1 6.7 0.015 15.4 6.7 1.4 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit HD_6 PF18019.1 ELR23479.1 - 6.9 6.8 7.1 14 5.7 5.8 2.2 2 1 1 3 3 3 0 HD domain LRR_8 PF13855.6 ELR23480.1 - 8e-16 57.6 11.0 3e-07 30.1 3.3 4.6 3 1 1 4 4 4 4 Leucine rich repeat LRR_4 PF12799.7 ELR23480.1 - 4.5e-07 30.1 11.5 0.2 12.1 1.8 4.7 2 1 3 5 5 5 5 Leucine Rich repeats (2 copies) DUF1360 PF07098.11 ELR23480.1 - 0.11 12.5 0.0 0.11 12.5 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1360) Rot1 PF10681.9 ELR23480.1 - 2.1 7.8 4.9 3.6 7.1 4.9 1.2 1 0 0 1 1 1 0 Chaperone for protein-folding within the ER, fungal TP53IP5 PF15331.6 ELR23481.1 - 1.2 9.2 5.9 1.5 8.9 5.9 1.1 1 0 0 1 1 1 0 Cellular tumour antigen p53-inducible 5 CBFB_NFYA PF02045.15 ELR23482.1 - 1.1e-21 77.2 5.5 1.1e-21 77.2 5.5 1.9 2 0 0 2 2 2 1 CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B Pkinase PF00069.25 ELR23483.1 - 9.8e-09 34.9 0.0 1.1e-08 34.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Myotub-related PF06602.14 ELR23484.1 - 2.1e-76 257.2 0.0 3.2e-76 256.6 0.0 1.3 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain Pkinase_Tyr PF07714.17 ELR23484.1 - 4.9e-52 176.8 0.0 1.3e-51 175.4 0.0 1.7 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ELR23484.1 - 3.6e-43 147.8 0.0 6.2e-43 147.1 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain COR PF16095.5 ELR23484.1 - 5.4e-40 137.3 0.0 8.6e-40 136.6 0.0 1.3 1 0 0 1 1 1 1 C-terminal of Roc, COR, domain LRR_8 PF13855.6 ELR23484.1 - 9.4e-24 83.0 28.6 1.5e-05 24.6 1.7 6.4 5 1 1 6 6 6 6 Leucine rich repeat Roc PF08477.13 ELR23484.1 - 4.7e-20 72.0 1.4 1.4e-16 60.8 0.0 3.1 3 0 0 3 3 3 2 Ras of Complex, Roc, domain of DAPkinase LRR_4 PF12799.7 ELR23484.1 - 6.3e-15 55.0 31.3 0.0011 19.4 1.2 8.4 6 2 3 9 9 9 7 Leucine Rich repeats (2 copies) PH PF00169.29 ELR23484.1 - 9e-12 45.4 0.0 3.2e-11 43.7 0.0 2.1 1 0 0 1 1 1 1 PH domain Ras PF00071.22 ELR23484.1 - 5.8e-07 29.3 0.0 2.6e-05 23.9 0.0 2.6 2 0 0 2 2 2 1 Ras family LRR_9 PF14580.6 ELR23484.1 - 0.0002 20.9 5.0 0.0047 16.4 0.5 2.7 2 0 0 2 2 2 1 Leucine-rich repeat LRR_1 PF00560.33 ELR23484.1 - 0.0011 19.2 35.4 8.4 7.4 0.9 11.1 11 1 0 11 11 9 1 Leucine Rich Repeat DUF4714 PF15833.5 ELR23484.1 - 0.044 13.8 2.5 0.091 12.7 2.5 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4714) Bac_export_2 PF01312.19 ELR23484.1 - 0.056 12.7 1.5 0.095 11.9 1.5 1.2 1 0 0 1 1 1 0 FlhB HrpN YscU SpaS Family PH_2 PF08458.10 ELR23484.1 - 0.081 13.3 0.0 0.24 11.8 0.0 1.7 1 0 0 1 1 1 0 Plant pleckstrin homology-like region PH_13 PF16652.5 ELR23484.1 - 0.12 12.2 0.5 0.47 10.3 0.5 2.0 2 0 0 2 2 2 0 Pleckstrin homology domain PH_11 PF15413.6 ELR23484.1 - 0.16 12.4 3.7 0.098 13.1 0.2 2.5 2 0 0 2 2 2 0 Pleckstrin homology domain LRR_6 PF13516.6 ELR23484.1 - 2.3 8.5 21.3 41 4.6 0.1 8.4 10 0 0 10 10 8 0 Leucine Rich repeat Syntaxin PF00804.25 ELR23485.1 - 4.5e-08 33.0 9.5 5.1e-05 23.0 1.4 2.1 2 0 0 2 2 2 2 Syntaxin SNARE PF05739.19 ELR23485.1 - 0.014 15.3 1.0 0.048 13.7 0.1 2.3 2 0 0 2 2 2 0 SNARE domain FtsX PF02687.21 ELR23485.1 - 0.04 14.4 1.1 0.058 13.9 1.1 1.2 1 0 0 1 1 1 0 FtsX-like permease family DUF2207 PF09972.9 ELR23485.1 - 0.041 12.7 0.1 0.054 12.3 0.1 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Laminin_II PF06009.12 ELR23485.1 - 0.2 11.7 4.3 0.28 11.2 1.0 2.2 2 0 0 2 2 2 0 Laminin Domain II CHAD PF05235.14 ELR23485.1 - 0.31 11.0 14.8 0.73 9.8 11.0 2.6 2 1 0 2 2 2 0 CHAD domain CsbD PF05532.12 ELR23486.1 - 1.7e-19 69.4 22.4 9.3e-13 47.9 9.5 2.0 1 1 1 2 2 2 2 CsbD-like PsiF_repeat PF07769.14 ELR23486.1 - 0.067 13.1 1.2 0.21 11.5 1.2 1.8 1 0 0 1 1 1 0 psiF repeat Staphylcoagulse PF04022.12 ELR23486.1 - 0.26 10.8 0.6 0.49 10.0 0.6 1.4 1 0 0 1 1 1 0 Staphylocoagulase repeat Siva PF05458.12 ELR23487.1 - 0.00016 21.4 3.6 0.00032 20.4 3.6 1.6 1 0 0 1 1 1 1 Cd27 binding protein (Siva) Prok-RING_2 PF14445.6 ELR23487.1 - 1.3 9.3 10.9 0.33 11.2 6.8 2.2 3 0 0 3 3 3 0 Prokaryotic RING finger family 2 ABC_tran PF00005.27 ELR23488.1 - 1.2e-45 155.4 0.1 7.8e-22 78.3 0.0 2.7 3 0 0 3 3 2 2 ABC transporter ABC_tran_Xtn PF12848.7 ELR23488.1 - 6.9e-22 77.3 4.3 3.2e-21 75.1 3.1 2.5 2 0 0 2 2 2 1 ABC transporter AAA_21 PF13304.6 ELR23488.1 - 1.2e-18 68.0 2.7 1.7e-05 24.8 0.0 4.2 3 1 1 4 4 4 4 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 ELR23488.1 - 3.9e-07 29.7 0.2 0.75 9.2 0.0 4.0 3 1 0 3 3 3 3 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 ELR23488.1 - 7.3e-07 28.8 0.0 0.0063 16.2 0.0 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_15 PF13175.6 ELR23488.1 - 3.6e-06 26.9 0.0 0.011 15.5 0.0 3.0 2 1 1 3 3 3 2 AAA ATPase domain RsgA_GTPase PF03193.16 ELR23488.1 - 1.1e-05 25.5 0.0 0.0052 16.7 0.0 2.6 2 0 0 2 2 2 1 RsgA GTPase MMR_HSR1 PF01926.23 ELR23488.1 - 4.3e-05 23.6 0.0 0.058 13.5 0.0 2.7 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_28 PF13521.6 ELR23488.1 - 4.6e-05 23.7 2.1 0.089 13.0 0.1 3.2 4 0 0 4 4 2 2 AAA domain AAA_24 PF13479.6 ELR23488.1 - 5.8e-05 22.9 0.0 0.15 11.8 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_33 PF13671.6 ELR23488.1 - 0.00013 22.2 1.0 0.37 10.9 0.0 3.1 2 1 1 3 3 3 2 AAA domain AAA_16 PF13191.6 ELR23488.1 - 0.00014 22.3 0.1 0.47 10.8 0.0 2.7 2 0 0 2 2 2 2 AAA ATPase domain AAA_23 PF13476.6 ELR23488.1 - 0.00016 22.2 7.3 0.014 16.0 0.0 3.2 4 0 0 4 4 3 2 AAA domain AAA_18 PF13238.6 ELR23488.1 - 0.00041 20.9 0.1 2.3 8.8 0.0 3.1 2 1 1 3 3 3 2 AAA domain AAA_22 PF13401.6 ELR23488.1 - 0.00042 20.6 0.1 1.2 9.4 0.0 2.9 2 1 0 2 2 2 2 AAA domain AAA_27 PF13514.6 ELR23488.1 - 0.00071 19.2 1.2 0.092 12.3 0.0 3.2 2 1 0 2 2 2 1 AAA domain AAA_25 PF13481.6 ELR23488.1 - 0.0012 18.5 0.0 1.7 8.2 0.0 2.8 2 0 0 2 2 2 2 AAA domain AAA_30 PF13604.6 ELR23488.1 - 0.0017 18.1 0.2 0.92 9.2 0.0 3.1 2 2 0 2 2 2 1 AAA domain Dynamin_N PF00350.23 ELR23488.1 - 0.0022 18.1 0.1 1.5 8.9 0.0 3.4 2 1 1 3 3 3 1 Dynamin family MeaB PF03308.16 ELR23488.1 - 0.0031 16.5 0.2 0.75 8.7 0.0 3.0 3 0 0 3 3 3 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_14 PF13173.6 ELR23488.1 - 0.0036 17.3 0.0 5.1 7.2 0.0 3.6 4 0 0 4 4 4 1 AAA domain SRP54 PF00448.22 ELR23488.1 - 0.0056 16.3 0.0 1.1 8.8 0.0 2.4 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain DUF87 PF01935.17 ELR23488.1 - 0.0077 16.3 0.0 0.95 9.5 0.0 2.8 2 1 0 2 2 2 1 Helicase HerA, central domain AAA_5 PF07728.14 ELR23488.1 - 0.018 15.0 0.1 6.6 6.7 0.0 3.2 3 0 0 3 3 3 0 AAA domain (dynein-related subfamily) AAA_7 PF12775.7 ELR23488.1 - 0.032 13.8 0.0 1.8 8.0 0.0 2.3 2 0 0 2 2 2 0 P-loop containing dynein motor region RNA_helicase PF00910.22 ELR23488.1 - 0.037 14.4 0.0 6.8 7.1 0.0 2.7 2 0 0 2 2 2 0 RNA helicase NACHT PF05729.12 ELR23488.1 - 0.042 13.8 0.2 5.1 7.0 0.0 2.5 2 0 0 2 2 2 0 NACHT domain AAA_13 PF13166.6 ELR23488.1 - 0.053 12.2 0.2 31 3.0 0.0 3.1 3 0 0 3 3 3 0 AAA domain Arf PF00025.21 ELR23488.1 - 0.065 12.7 0.2 20 4.6 0.0 3.0 3 0 0 3 3 3 0 ADP-ribosylation factor family Zeta_toxin PF06414.12 ELR23488.1 - 0.076 12.3 0.0 0.19 11.0 0.0 1.6 1 0 0 1 1 1 0 Zeta toxin AAA PF00004.29 ELR23488.1 - 0.08 13.4 0.0 24 5.4 0.0 2.9 3 0 0 3 3 2 0 ATPase family associated with various cellular activities (AAA) MukB PF04310.12 ELR23488.1 - 0.12 12.1 0.4 5.1 6.8 0.0 2.9 3 0 0 3 3 3 0 MukB N-terminal ABC_tran_CTD PF16326.5 ELR23488.1 - 0.68 10.2 9.1 0.37 11.1 3.8 2.9 2 0 0 2 2 2 0 ABC transporter C-terminal domain Ras PF00071.22 ELR23489.1 - 9.3e-45 152.1 0.3 1.1e-44 151.9 0.3 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR23489.1 - 1.4e-26 93.1 0.5 2e-26 92.6 0.5 1.1 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR23489.1 - 3.4e-12 46.2 0.2 3.6e-12 46.1 0.2 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 ELR23489.1 - 1.1e-06 28.4 0.2 3.6e-06 26.7 0.2 1.8 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 ELR23489.1 - 6.1e-05 23.1 0.0 8.9e-05 22.5 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 ELR23489.1 - 0.00014 21.3 0.0 0.0002 20.8 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region AAA PF00004.29 ELR23489.1 - 0.00058 20.3 0.0 0.002 18.5 0.0 1.9 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) CPT PF07931.12 ELR23489.1 - 0.013 15.3 0.1 0.64 9.8 0.0 2.2 1 1 1 2 2 2 0 Chloramphenicol phosphotransferase-like protein Oxidored_FMN PF00724.20 ELR23489.1 - 0.023 14.0 0.0 0.03 13.6 0.0 1.1 1 0 0 1 1 1 0 NADH:flavin oxidoreductase / NADH oxidase family AAA_16 PF13191.6 ELR23489.1 - 0.04 14.3 0.0 0.065 13.6 0.0 1.5 1 1 0 1 1 1 0 AAA ATPase domain Aldo_ket_red PF00248.21 ELR23491.1 - 1.1e-45 156.1 0.0 9e-34 117.0 0.0 2.8 1 1 1 2 2 2 2 Aldo/keto reductase family AIRS_C PF02769.22 ELR23493.1 - 0.069 13.3 0.2 0.98 9.5 0.1 2.2 1 1 1 2 2 2 0 AIR synthase related protein, C-terminal domain Ank_2 PF12796.7 ELR23494.1 - 3.2e-26 91.7 0.4 9.4e-09 35.7 0.0 5.0 3 2 1 4 4 4 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ELR23494.1 - 3.4e-22 78.5 3.0 6.1e-08 33.1 0.1 5.8 4 1 2 7 7 7 4 Ankyrin repeats (many copies) Ank_5 PF13857.6 ELR23494.1 - 9.1e-21 73.7 2.9 1.6e-08 34.6 0.1 5.5 4 1 1 5 5 5 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 ELR23494.1 - 1.4e-19 68.1 4.4 0.0001 22.4 0.0 8.3 8 0 0 8 8 8 3 Ankyrin repeat Ank PF00023.30 ELR23494.1 - 2.1e-18 65.9 7.6 2.8e-06 27.5 0.0 8.3 8 0 0 8 8 8 2 Ankyrin repeat F-box-like PF12937.7 ELR23494.1 - 3.1e-10 39.8 0.0 6.1e-10 38.8 0.0 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ELR23494.1 - 3.3e-07 30.0 0.0 6.5e-07 29.1 0.0 1.5 1 0 0 1 1 1 1 F-box domain LETM1 PF07766.13 ELR23495.1 - 3.3e-27 95.5 0.2 7.1e-26 91.1 0.2 2.2 1 1 0 1 1 1 1 LETM1-like protein RhoGAP PF00620.27 ELR23496.1 - 1.3e-22 80.3 0.0 2.6e-22 79.3 0.0 1.5 1 0 0 1 1 1 1 RhoGAP domain DEP PF00610.21 ELR23496.1 - 1e-05 25.5 0.0 2.2e-05 24.4 0.0 1.5 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) RRM_3 PF08777.11 ELR23496.1 - 0.099 12.7 0.0 0.099 12.7 0.0 3.1 3 0 0 3 3 3 0 RNA binding motif Mucin PF01456.17 ELR23496.1 - 0.93 9.5 16.6 4.1 7.4 8.3 3.0 3 0 0 3 3 3 0 Mucin-like glycoprotein FAM91_C PF14648.6 ELR23497.1 - 0.03 13.1 0.5 0.062 12.1 0.5 1.4 1 0 0 1 1 1 0 FAM91 C-terminus RNA_ligase PF09414.10 ELR23498.1 - 4.7e-26 92.0 0.0 6.6e-26 91.5 0.0 1.2 1 0 0 1 1 1 1 RNA ligase IQCJ-SCHIP1 PF15157.6 ELR23498.1 - 0.018 14.9 0.1 0.027 14.3 0.1 1.3 1 0 0 1 1 1 0 Fusion protein IQCJ-SCHIP1 with IQ-like motif SR-25 PF10500.9 ELR23498.1 - 1.9 8.1 18.7 0.51 9.9 11.3 2.2 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein DUF3446 PF11928.8 ELR23498.1 - 4.5 7.6 15.5 0.47 10.8 6.4 2.2 2 0 0 2 2 2 0 Early growth response N-terminal domain CENP-H PF05837.12 ELR23499.1 - 0.68 10.4 2.8 0.53 10.7 0.4 1.9 2 0 0 2 2 2 0 Centromere protein H (CENP-H) Tropomyosin_1 PF12718.7 ELR23501.1 - 0.0046 17.1 2.4 0.0068 16.6 2.4 1.3 1 0 0 1 1 1 1 Tropomyosin like TACC_C PF05010.14 ELR23501.1 - 0.012 15.4 3.2 0.017 14.9 3.2 1.2 1 0 0 1 1 1 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal Ad_Cy_reg PF16701.5 ELR23501.1 - 0.04 13.6 0.6 0.058 13.1 0.6 1.2 1 0 0 1 1 1 0 Adenylate cyclase regulatory domain ATG16 PF08614.11 ELR23501.1 - 0.19 11.9 10.4 0.32 11.2 10.4 1.3 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) FUSC PF04632.12 ELR23501.1 - 0.21 10.1 3.5 0.24 9.9 3.5 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family Lectin_N PF03954.14 ELR23501.1 - 0.3 10.8 3.5 1.1 9.0 0.8 2.1 1 1 1 2 2 2 0 Hepatic lectin, N-terminal domain SlyX PF04102.12 ELR23501.1 - 0.51 11.0 7.9 2 9.1 1.6 2.5 1 1 1 2 2 2 0 SlyX TMF_DNA_bd PF12329.8 ELR23501.1 - 0.69 9.9 4.4 6.9 6.7 3.4 2.4 1 1 1 2 2 2 0 TATA element modulatory factor 1 DNA binding HR1 PF02185.16 ELR23501.1 - 4 7.6 8.9 8.2 6.6 3.0 2.5 1 1 1 2 2 2 0 Hr1 repeat IPPT PF01715.17 ELR23502.1 - 1.2e-55 188.8 0.0 2e-55 188.1 0.0 1.3 1 0 0 1 1 1 1 IPP transferase AAA_33 PF13671.6 ELR23502.1 - 0.0014 18.8 0.6 0.045 13.9 0.0 2.7 3 0 0 3 3 3 1 AAA domain IstB_IS21 PF01695.17 ELR23502.1 - 0.0017 18.1 0.0 0.0029 17.4 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein ParA PF10609.9 ELR23502.1 - 0.0017 17.8 0.2 0.0025 17.3 0.2 1.2 1 0 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase PhoH PF02562.16 ELR23502.1 - 0.0029 17.1 0.1 0.005 16.3 0.1 1.3 1 0 0 1 1 1 1 PhoH-like protein AAA_25 PF13481.6 ELR23502.1 - 0.0077 15.8 0.0 0.022 14.4 0.0 1.7 1 0 0 1 1 1 1 AAA domain zf-met PF12874.7 ELR23502.1 - 0.0083 16.5 0.0 0.014 15.7 0.0 1.4 1 0 0 1 1 1 1 Zinc-finger of C2H2 type CbiA PF01656.23 ELR23502.1 - 0.011 15.8 0.0 0.019 15.0 0.0 1.5 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain RsgA_GTPase PF03193.16 ELR23502.1 - 0.013 15.4 0.1 0.022 14.7 0.1 1.3 1 0 0 1 1 1 0 RsgA GTPase Zeta_toxin PF06414.12 ELR23502.1 - 0.017 14.4 0.1 0.033 13.5 0.1 1.4 1 0 0 1 1 1 0 Zeta toxin zf-C2H2_jaz PF12171.8 ELR23502.1 - 0.018 15.3 0.0 0.034 14.4 0.0 1.4 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding SRP54 PF00448.22 ELR23502.1 - 0.022 14.4 0.1 0.037 13.7 0.1 1.3 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain AAA_22 PF13401.6 ELR23502.1 - 0.042 14.1 0.0 0.14 12.4 0.0 1.8 1 1 1 2 2 2 0 AAA domain OrsD PF12013.8 ELR23502.1 - 0.088 13.3 0.2 0.088 13.3 0.2 2.3 3 0 0 3 3 3 0 Orsellinic acid/F9775 biosynthesis cluster protein D ABC_tran PF00005.27 ELR23502.1 - 0.11 13.0 0.0 0.22 12.0 0.0 1.4 1 0 0 1 1 1 0 ABC transporter AAA_7 PF12775.7 ELR23502.1 - 0.15 11.6 0.0 0.26 10.8 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region Ras PF00071.22 ELR23502.1 - 0.21 11.2 0.0 14 5.2 0.1 2.2 2 0 0 2 2 2 0 Ras family MFS_1 PF07690.16 ELR23503.1 - 1.2e-12 47.4 39.8 8.8e-08 31.5 13.6 2.9 1 1 2 3 3 3 2 Major Facilitator Superfamily DUF4094 PF13334.6 ELR23503.1 - 3.3 8.2 5.7 21 5.6 0.0 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4094) OATP PF03137.20 ELR23503.1 - 3.4 5.8 10.4 1.3 7.2 0.6 2.7 3 0 0 3 3 3 0 Organic Anion Transporter Polypeptide (OATP) family Sec63 PF02889.16 ELR23504.1 - 6.3e-150 497.4 0.0 2.4e-78 262.9 0.0 2.5 2 0 0 2 2 2 2 Sec63 Brl domain DEAD PF00270.29 ELR23504.1 - 6.5e-54 182.3 0.0 1.4e-28 99.8 0.3 2.7 2 0 0 2 2 2 2 DEAD/DEAH box helicase ResIII PF04851.15 ELR23504.1 - 1.3e-26 93.6 0.0 9.2e-15 55.1 0.0 2.5 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit Helicase_C PF00271.31 ELR23504.1 - 2.2e-15 56.9 0.0 2.4e-06 27.9 0.0 3.7 3 2 0 3 3 2 2 Helicase conserved C-terminal domain AAA_22 PF13401.6 ELR23504.1 - 7.2e-08 32.8 0.2 0.0032 17.7 0.1 3.6 2 1 0 2 2 2 2 AAA domain AAA_19 PF13245.6 ELR23504.1 - 0.00017 22.0 0.2 0.016 15.6 0.2 2.7 2 0 0 2 2 2 1 AAA domain Helicase_PWI PF18149.1 ELR23504.1 - 0.00027 21.1 0.2 0.0018 18.4 0.1 2.4 2 0 0 2 2 2 1 N-terminal helicase PWI domain T2SSE PF00437.20 ELR23504.1 - 0.001 18.2 0.0 1.1 8.2 0.0 2.4 2 0 0 2 2 2 2 Type II/IV secretion system protein AAA_25 PF13481.6 ELR23504.1 - 0.0019 17.8 0.6 0.55 9.8 0.0 3.4 3 0 0 3 3 3 1 AAA domain UvrD-helicase PF00580.21 ELR23504.1 - 0.0071 15.9 0.0 0.32 10.5 0.1 2.4 2 0 0 2 2 2 1 UvrD/REP helicase N-terminal domain AAA_7 PF12775.7 ELR23504.1 - 0.0083 15.7 0.0 2.6 7.5 0.0 2.7 3 0 0 3 3 3 1 P-loop containing dynein motor region AAA_11 PF13086.6 ELR23504.1 - 0.0099 15.7 0.0 0.43 10.3 0.0 3.0 3 1 0 3 3 3 1 AAA domain PhoH PF02562.16 ELR23504.1 - 0.014 14.9 0.0 1.6 8.2 0.1 2.4 2 0 0 2 2 2 0 PhoH-like protein Nop14 PF04147.12 ELR23504.1 - 0.068 11.4 2.0 0.11 10.7 2.0 1.2 1 0 0 1 1 1 0 Nop14-like family Prothymosin PF03247.14 ELR23504.1 - 0.089 13.3 14.6 0.21 12.1 14.6 1.5 1 0 0 1 1 1 0 Prothymosin/parathymosin family Mg_chelatase PF01078.21 ELR23504.1 - 0.11 11.8 0.0 13 5.1 0.0 2.5 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI PBP1_TM PF14812.6 ELR23504.1 - 4.7 7.7 12.0 18 5.8 12.0 2.0 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Importin_rep_4 PF18808.1 ELR23506.1 - 1.8e-26 92.2 4.0 4.2e-26 91.0 0.0 3.5 3 0 0 3 3 2 1 Importin repeat HEAT PF02985.22 ELR23506.1 - 4.4e-19 66.9 0.4 0.005 17.0 0.0 8.3 7 0 0 7 7 7 4 HEAT repeat HEAT_EZ PF13513.6 ELR23506.1 - 4.5e-18 65.4 7.5 0.00095 19.6 0.0 9.7 9 1 1 10 10 10 4 HEAT-like repeat HEAT_2 PF13646.6 ELR23506.1 - 1.8e-14 53.9 0.0 5.5e-06 26.7 0.0 6.1 5 1 1 6 6 5 2 HEAT repeats RIX1 PF08167.12 ELR23506.1 - 4.1e-10 39.7 0.0 0.22 11.2 0.0 6.2 6 0 0 6 6 6 2 rRNA processing/ribosome biogenesis Vac14_Fab1_bd PF12755.7 ELR23506.1 - 4.7e-09 36.7 0.0 0.061 13.9 0.0 6.9 5 2 3 8 8 8 1 Vacuolar 14 Fab1-binding region DUF3385 PF11865.8 ELR23506.1 - 4.8e-07 29.8 8.1 0.039 13.9 0.0 7.5 6 3 1 8 8 8 2 Domain of unknown function (DUF3385) CLASP_N PF12348.8 ELR23506.1 - 9.1e-07 28.7 6.6 0.55 9.8 0.2 7.4 6 3 4 10 10 10 2 CLASP N terminal Tti2 PF10521.9 ELR23506.1 - 6.7e-05 22.6 0.4 0.48 9.9 0.2 4.4 4 0 0 4 4 4 1 Tti2 family Cnd1 PF12717.7 ELR23506.1 - 0.0003 20.9 4.0 3.6 7.6 0.0 4.7 3 2 0 4 4 4 1 non-SMC mitotic condensation complex subunit 1 IBN_N PF03810.19 ELR23506.1 - 0.0057 16.5 2.5 0.14 12.1 0.3 3.8 4 0 0 4 4 4 1 Importin-beta N-terminal domain Cohesin_HEAT PF12765.7 ELR23506.1 - 0.0064 16.8 0.0 4.6 7.6 0.0 3.4 3 0 0 3 3 3 1 HEAT repeat associated with sister chromatid cohesion Arm PF00514.23 ELR23506.1 - 0.011 15.8 0.1 15 5.8 0.0 4.7 4 0 0 4 4 4 0 Armadillo/beta-catenin-like repeat Nipped-B_C PF12830.7 ELR23506.1 - 0.087 12.8 0.3 6.9 6.6 0.0 3.0 2 1 0 2 2 2 0 Sister chromatid cohesion C-terminus Utp12 PF04003.12 ELR23506.1 - 0.74 10.1 4.4 20 5.5 0.1 4.2 4 0 0 4 4 4 0 Dip2/Utp12 Family Xpo1 PF08389.12 ELR23506.1 - 1.1 9.4 5.3 1.2 9.1 0.3 3.6 3 1 0 3 3 3 0 Exportin 1-like protein Adap_comp_sub PF00928.21 ELR23507.1 - 1e-30 107.1 0.0 1.2e-30 106.7 0.0 1.1 1 0 0 1 1 1 1 Adaptor complexes medium subunit family SH3_9 PF14604.6 ELR23509.1 - 7.3e-11 41.8 0.1 1.3e-10 41.0 0.1 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 ELR23509.1 - 1e-10 41.0 0.1 1.9e-10 40.2 0.1 1.5 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 ELR23509.1 - 1.4e-10 40.7 0.2 2.3e-10 40.0 0.2 1.4 1 0 0 1 1 1 1 Variant SH3 domain WH2 PF02205.20 ELR23509.1 - 1.3e-09 37.6 1.2 1.3e-09 37.6 1.2 2.1 2 0 0 2 2 2 1 WH2 motif HMG_box PF00505.19 ELR23510.1 - 2.1e-19 69.7 0.1 3.4e-19 69.0 0.1 1.4 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 ELR23510.1 - 2.5e-09 37.6 0.0 4.6e-09 36.8 0.0 1.4 1 0 0 1 1 1 1 HMG-box domain CHDNT PF08073.12 ELR23510.1 - 0.059 13.3 0.0 0.095 12.7 0.0 1.3 1 0 0 1 1 1 0 CHDNT (NUC034) domain DUF1582 PF07621.11 ELR23510.1 - 0.11 12.5 1.1 15 5.6 0.1 3.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1582) Peptidase_S9_N PF02897.15 ELR23511.1 - 8.7e-62 209.2 0.0 1.2e-61 208.8 0.0 1.1 1 0 0 1 1 1 1 Prolyl oligopeptidase, N-terminal beta-propeller domain Peptidase_S9 PF00326.21 ELR23511.1 - 2.9e-55 187.1 0.0 5e-55 186.3 0.0 1.4 1 0 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_3 PF07859.13 ELR23511.1 - 0.023 14.6 0.0 0.043 13.7 0.0 1.4 1 0 0 1 1 1 0 alpha/beta hydrolase fold AXE1 PF05448.12 ELR23511.1 - 0.082 11.6 0.0 0.14 10.9 0.0 1.2 1 0 0 1 1 1 0 Acetyl xylan esterase (AXE1) PD40 PF07676.12 ELR23511.1 - 8.6 6.4 5.6 1.7e+02 2.3 0.0 4.1 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat C2 PF00168.30 ELR23512.1 - 3.8e-28 97.8 0.1 5e-28 97.4 0.1 1.1 1 0 0 1 1 1 1 C2 domain CEP76-C2 PF15627.6 ELR23512.1 - 0.0074 15.9 0.0 0.0085 15.7 0.0 1.2 1 0 0 1 1 1 1 CEP76 C2 domain DUF2393 PF09624.10 ELR23512.1 - 0.098 12.7 0.0 0.13 12.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2393) Arf PF00025.21 ELR23513.1 - 4.3e-68 228.2 0.2 4.8e-68 228.0 0.2 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 ELR23513.1 - 1.8e-14 54.0 0.1 2.6e-14 53.4 0.1 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 ELR23513.1 - 4.5e-13 49.1 0.1 5.4e-13 48.9 0.1 1.1 1 0 0 1 1 1 1 Ras family SRPRB PF09439.10 ELR23513.1 - 4.2e-12 45.9 0.0 5e-12 45.6 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.20 ELR23513.1 - 1.1e-10 41.3 0.7 8.5e-08 31.7 0.1 2.3 1 1 1 2 2 2 2 G-protein alpha subunit Gtr1_RagA PF04670.12 ELR23513.1 - 1.7e-09 37.4 0.0 2.1e-09 37.1 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 ELR23513.1 - 5.1e-06 26.5 0.0 8.2e-06 25.9 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase ABC_tran PF00005.27 ELR23513.1 - 0.013 16.0 0.3 0.13 12.8 0.3 1.9 1 1 0 1 1 1 0 ABC transporter 6PF2K PF01591.18 ELR23513.1 - 0.15 11.3 0.0 0.23 10.7 0.0 1.2 1 0 0 1 1 1 0 6-phosphofructo-2-kinase BK_channel_a PF03493.18 ELR23514.1 - 5.6e-18 64.9 0.0 1.3e-17 63.7 0.0 1.6 1 0 0 1 1 1 1 Calcium-activated BK potassium channel alpha subunit Ion_trans_2 PF07885.16 ELR23514.1 - 7e-12 45.2 8.4 7e-12 45.2 8.4 2.7 3 0 0 3 3 3 1 Ion channel Ion_trans PF00520.31 ELR23514.1 - 2.7e-11 43.2 24.6 2.7e-11 43.2 24.6 1.9 2 0 0 2 2 2 1 Ion transport protein GspL_C PF12693.7 ELR23514.1 - 0.0024 17.7 0.0 0.022 14.6 0.0 2.3 2 0 0 2 2 2 1 GspL periplasmic domain TrkA_N PF02254.18 ELR23514.1 - 0.11 12.8 0.0 0.3 11.4 0.0 1.7 1 0 0 1 1 1 0 TrkA-N domain zf-C2H2_2 PF12756.7 ELR23516.1 - 0.037 14.4 0.0 0.085 13.2 0.0 1.6 1 1 0 1 1 1 0 C2H2 type zinc-finger (2 copies) EF-hand_6 PF13405.6 ELR23517.1 - 4.9e-16 57.2 0.4 0.00093 19.0 0.0 4.6 4 1 1 5 5 5 3 EF-hand domain EF-hand_1 PF00036.32 ELR23517.1 - 5.5e-15 53.7 0.3 0.00052 19.4 0.0 4.3 5 0 0 5 5 5 3 EF hand EF-hand_5 PF13202.6 ELR23517.1 - 2.1e-12 46.0 0.1 0.00052 19.4 0.0 3.3 3 0 0 3 3 3 3 EF hand EF-hand_7 PF13499.6 ELR23517.1 - 5.5e-11 42.8 0.1 1.9e-05 25.0 0.1 3.1 1 1 2 3 3 3 3 EF-hand domain pair EF-hand_8 PF13833.6 ELR23517.1 - 6.8e-06 25.8 0.3 0.99 9.3 0.1 3.7 2 2 2 4 4 4 2 EF-hand domain pair EF-hand_10 PF14788.6 ELR23517.1 - 0.14 12.0 0.0 0.6 10.0 0.0 2.0 2 0 0 2 2 2 0 EF hand 2OG-FeII_Oxy_2 PF13532.6 ELR23518.1 - 9e-14 52.1 0.0 5.3e-13 49.6 0.0 1.8 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DUF1987 PF09345.10 ELR23518.1 - 0.016 14.9 0.0 0.024 14.3 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1987) MMR_HSR1 PF01926.23 ELR23521.1 - 2.5e-20 72.7 0.0 3.8e-20 72.1 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 ELR23521.1 - 2.7e-07 30.3 0.0 4.7e-07 29.5 0.0 1.4 1 1 0 1 1 1 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 ELR23521.1 - 6.9e-06 26.1 0.0 0.0013 18.7 0.0 2.2 2 0 0 2 2 2 1 RsgA GTPase GTP_EFTU PF00009.27 ELR23521.1 - 9.1e-05 22.1 0.0 0.0055 16.3 0.0 2.3 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain Dynamin_N PF00350.23 ELR23521.1 - 0.0002 21.5 0.8 0.004 17.2 0.2 2.4 1 1 1 2 2 2 1 Dynamin family SRPRB PF09439.10 ELR23521.1 - 0.00035 20.1 0.0 0.00051 19.5 0.0 1.4 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Septin PF00735.18 ELR23521.1 - 0.061 12.6 0.0 0.31 10.3 0.0 2.0 2 0 0 2 2 2 0 Septin Roc PF08477.13 ELR23521.1 - 0.069 13.4 0.0 0.15 12.3 0.0 1.6 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase ABC_tran PF00005.27 ELR23521.1 - 0.13 12.8 0.0 0.31 11.6 0.0 1.6 1 1 0 1 1 1 0 ABC transporter AIG1 PF04548.16 ELR23521.1 - 0.15 11.3 0.0 0.25 10.7 0.0 1.4 1 0 0 1 1 1 0 AIG1 family DUF3830 PF12903.7 ELR23521.1 - 0.15 11.7 0.1 0.34 10.6 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3830) SMN PF06003.12 ELR23521.1 - 0.41 9.9 2.7 0.55 9.4 2.5 1.3 1 1 0 1 1 1 0 Survival motor neuron protein (SMN) NAC PF01849.18 ELR23522.1 - 4e-21 74.7 0.0 5.7e-21 74.3 0.0 1.2 1 0 0 1 1 1 1 NAC domain Ribosomal_60s PF00428.19 ELR23522.1 - 0.014 15.9 0.7 0.026 15.1 0.7 1.4 1 0 0 1 1 1 0 60s Acidic ribosomal protein Gly_transf_sug PF04488.15 ELR23523.1 - 1.2e-09 38.7 0.1 3.2e-09 37.3 0.1 1.7 1 1 1 2 2 2 1 Glycosyltransferase sugar-binding region containing DXD motif TcdA_TcdB PF12919.7 ELR23523.1 - 0.00028 20.3 1.8 0.0004 19.8 0.2 1.8 1 1 0 2 2 2 1 TcdA/TcdB catalytic glycosyltransferase domain Caps_synth PF05704.12 ELR23523.1 - 0.025 14.0 0.0 0.066 12.6 0.0 1.7 2 0 0 2 2 2 0 Capsular polysaccharide synthesis protein LRR_4 PF12799.7 ELR23524.1 - 5e-05 23.6 3.5 5.3 7.6 0.0 6.3 5 3 1 6 6 6 1 Leucine Rich repeats (2 copies) TraG_N PF07916.11 ELR23524.1 - 0.0039 16.1 0.7 0.0055 15.6 0.7 1.2 1 0 0 1 1 1 1 TraG-like protein, N-terminal region RIFIN PF02009.16 ELR23524.1 - 0.066 13.1 6.6 0.14 12.1 6.6 1.5 1 0 0 1 1 1 0 Rifin DUF2207 PF09972.9 ELR23524.1 - 0.2 10.4 0.3 0.31 9.8 0.3 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) LRR_8 PF13855.6 ELR23524.1 - 0.27 11.0 1.3 3.4 7.5 0.1 3.3 3 0 0 3 3 3 0 Leucine rich repeat Shisa PF13908.6 ELR23524.1 - 0.61 10.3 2.7 0.36 11.0 0.4 1.7 2 0 0 2 2 2 0 Wnt and FGF inhibitory regulator Phage_holin_3_6 PF07332.11 ELR23524.1 - 1.6 8.8 8.1 3.5 7.7 7.8 1.6 1 1 0 1 1 1 0 Putative Actinobacterial Holin-X, holin superfamily III Ferlin_C PF16165.5 ELR23524.1 - 8.4 6.3 5.6 0.92 9.4 0.9 1.8 2 0 0 2 2 2 0 Ferlin C-terminus Pkinase_Tyr PF07714.17 ELR23525.1 - 6e-54 183.0 0.0 8e-54 182.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ELR23525.1 - 3.9e-53 180.5 0.0 5.9e-53 179.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Kinase-like PF14531.6 ELR23525.1 - 0.00027 20.4 0.0 0.0085 15.4 0.0 2.3 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.14 ELR23525.1 - 0.0019 17.6 0.1 0.0031 16.9 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 ELR23525.1 - 0.0078 15.2 0.1 0.0078 15.2 0.1 1.7 2 0 0 2 2 2 1 Haspin like kinase domain Pkinase_fungal PF17667.1 ELR23525.1 - 0.021 13.6 0.2 0.077 11.8 0.0 1.9 2 0 0 2 2 2 0 Fungal protein kinase APH PF01636.23 ELR23525.1 - 0.028 14.3 0.1 0.052 13.4 0.1 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family ubiquitin PF00240.23 ELR23526.1 - 9.1e-26 89.4 0.0 5.2e-17 61.4 0.0 2.9 2 1 1 3 3 3 2 Ubiquitin family Rad60-SLD PF11976.8 ELR23526.1 - 3.8e-11 42.7 0.0 1.2e-06 28.2 0.0 2.5 2 0 0 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like zf-RING_2 PF13639.6 ELR23526.1 - 6.4e-10 39.2 12.5 6.4e-10 39.2 12.5 2.8 3 0 0 3 3 3 1 Ring finger domain zf-rbx1 PF12678.7 ELR23526.1 - 4.6e-06 26.8 7.3 4.6e-06 26.8 7.3 2.1 2 0 0 2 2 2 1 RING-H2 zinc finger domain zf-RING_11 PF17123.5 ELR23526.1 - 4.3e-05 23.2 10.2 4.3e-05 23.2 10.2 2.6 3 0 0 3 3 3 1 RING-like zinc finger Ubiquitin_2 PF14560.6 ELR23526.1 - 0.00022 21.6 0.0 2.5 8.6 0.0 3.5 3 1 0 3 3 3 2 Ubiquitin-like domain zf-C3HC4 PF00097.25 ELR23526.1 - 0.0019 18.0 11.9 0.0019 18.0 11.9 2.6 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 ELR23526.1 - 0.011 15.5 12.1 0.011 15.5 12.1 2.6 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ELR23526.1 - 0.11 12.5 15.8 0.026 14.5 10.4 2.3 2 0 0 2 2 2 0 zinc-RING finger domain zf-C3HC4_3 PF13920.6 ELR23526.1 - 3.5 7.6 19.2 0.28 11.1 9.2 2.4 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Cyclin_N PF00134.23 ELR23527.1 - 1.5e-36 124.9 0.1 5.3e-34 116.7 0.1 2.5 2 0 0 2 2 2 2 Cyclin, N-terminal domain Cyclin_C PF02984.19 ELR23527.1 - 7.4e-22 77.7 0.1 1.2e-17 64.1 0.1 2.8 2 0 0 2 2 2 2 Cyclin, C-terminal domain TFIIB PF00382.19 ELR23527.1 - 0.0002 21.3 0.9 0.3 11.2 0.1 3.0 3 0 0 3 3 3 2 Transcription factor TFIIB repeat Dicty_REP PF05086.12 ELR23527.1 - 4.9 5.0 9.5 7.1 4.5 9.5 1.2 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Piwi PF02171.17 ELR23529.1 - 2.3e-47 161.7 0.0 1.6e-40 139.2 0.0 2.2 1 1 1 2 2 2 2 Piwi domain PAZ PF02170.22 ELR23529.1 - 1.5e-23 83.1 0.4 2.8e-23 82.2 0.4 1.4 1 0 0 1 1 1 1 PAZ domain DUF1998 PF09369.10 ELR23529.1 - 0.11 13.2 0.0 1.2 9.9 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF1998) PSI PF01437.25 ELR23530.1 - 0.024 15.2 13.6 0.024 15.2 13.6 3.6 3 1 0 3 3 3 0 Plexin repeat RhoGAP PF00620.27 ELR23531.1 - 2.1e-30 105.5 0.0 3.6e-30 104.8 0.0 1.3 1 0 0 1 1 1 1 RhoGAP domain Pkinase_Tyr PF07714.17 ELR23532.1 - 2e-45 155.1 0.0 3.2e-45 154.5 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ELR23532.1 - 4.9e-36 124.5 0.0 1e-35 123.4 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain SH2 PF00017.24 ELR23532.1 - 9.9e-15 54.4 0.0 2.3e-14 53.3 0.0 1.6 1 0 0 1 1 1 1 SH2 domain Haspin_kinase PF12330.8 ELR23532.1 - 0.0006 18.9 0.0 0.0013 17.8 0.0 1.5 1 0 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 ELR23532.1 - 0.0038 17.2 0.0 0.01 15.8 0.0 1.6 1 0 0 1 1 1 1 Phosphotransferase enzyme family GTP_EFTU PF00009.27 ELR23533.1 - 4.8e-26 91.5 0.0 8.2e-26 90.7 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 ELR23533.1 - 1.6e-10 41.3 0.5 1.4e-09 38.2 0.0 2.2 2 0 0 2 2 2 1 Elongation factor Tu C-terminal domain F-box-like PF12937.7 ELR23533.1 - 5e-07 29.5 0.0 1.1e-06 28.4 0.0 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ELR23533.1 - 8e-05 22.4 0.1 0.00013 21.7 0.1 1.4 1 0 0 1 1 1 1 F-box domain MMR_HSR1 PF01926.23 ELR23533.1 - 0.00016 21.7 0.8 0.002 18.2 0.8 2.6 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_29 PF13555.6 ELR23533.1 - 0.0006 19.5 0.1 0.0016 18.2 0.1 1.7 1 0 0 1 1 1 1 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 ELR23533.1 - 0.004 17.1 1.4 0.12 12.3 0.1 2.7 2 1 0 2 2 2 1 RsgA GTPase G-alpha PF00503.20 ELR23533.1 - 0.0041 16.3 0.7 0.019 14.1 0.6 1.5 1 1 1 2 2 2 1 G-protein alpha subunit Mg_chelatase PF01078.21 ELR23533.1 - 0.005 16.2 0.0 0.009 15.4 0.0 1.3 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI DUF3716 PF12511.8 ELR23533.1 - 0.0079 16.2 0.6 0.018 15.0 0.6 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF3716) MCM PF00493.23 ELR23533.1 - 0.01 14.9 0.0 0.018 14.2 0.0 1.3 1 0 0 1 1 1 0 MCM P-loop domain ATP_bind_1 PF03029.17 ELR23533.1 - 0.094 12.5 0.1 3.5 7.3 0.0 2.2 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein AAA_5 PF07728.14 ELR23533.1 - 0.14 12.1 0.0 0.3 11.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_28 PF13521.6 ELR23533.1 - 0.19 12.0 0.1 0.36 11.0 0.1 1.4 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 ELR23533.1 - 1.1 9.9 3.7 3.8 8.1 3.7 2.0 1 1 0 1 1 1 0 AAA domain zf-C2HE PF16278.5 ELR23535.1 - 0.015 15.7 1.3 0.015 15.7 1.3 2.5 3 0 0 3 3 3 0 C2HE / C2H2 / C2HC zinc-binding finger zf-TRAF PF02176.18 ELR23535.1 - 0.032 14.9 35.5 0.19 12.4 2.4 5.8 3 3 3 6 6 6 0 TRAF-type zinc finger zf-TRAF_2 PF15965.5 ELR23535.1 - 0.04 14.4 29.3 0.043 14.3 9.3 3.8 2 2 3 5 5 5 0 TRAF-like zinc-finger zf_C2HC_14 PF18574.1 ELR23535.1 - 0.044 13.6 7.6 1 9.2 0.5 3.3 2 1 1 3 3 3 0 C2HC Zing finger domain Transpos_assoc PF13963.6 ELR23535.1 - 0.049 13.9 3.6 0.21 11.9 0.3 2.6 1 1 1 2 2 2 0 Transposase-associated domain GOLD_2 PF13897.6 ELR23536.1 - 2.3e-05 24.9 12.6 0.00011 22.7 0.4 3.4 1 1 2 3 3 3 2 Golgi-dynamics membrane-trafficking CoA_transf_3 PF02515.17 ELR23538.1 - 3.4e-117 391.7 0.0 1.7e-115 386.1 0.0 2.0 1 1 0 1 1 1 1 CoA-transferase family III SAM_4 PF18017.1 ELR23538.1 - 0.012 15.6 0.0 0.027 14.5 0.0 1.5 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) HTH_43 PF09904.9 ELR23538.1 - 0.075 13.0 0.0 0.17 11.9 0.0 1.5 1 0 0 1 1 1 0 Winged helix-turn helix adh_short PF00106.25 ELR23539.1 - 5.7e-37 127.1 0.0 9.5e-37 126.4 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ELR23539.1 - 7.3e-23 81.3 0.0 2.3e-22 79.7 0.0 1.6 1 1 1 2 2 2 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ELR23539.1 - 3.9e-05 23.6 0.0 9.2e-05 22.4 0.0 1.5 1 1 0 1 1 1 1 KR domain Epimerase PF01370.21 ELR23539.1 - 0.0098 15.4 0.1 0.017 14.6 0.1 1.6 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 ELR23539.1 - 0.04 13.0 0.0 0.066 12.3 0.0 1.4 2 0 0 2 2 2 0 Polysaccharide biosynthesis protein Pyr_redox_2 PF07992.14 ELR23539.1 - 0.07 12.3 0.0 0.11 11.7 0.0 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Y_phosphatase3 PF13350.6 ELR23540.1 - 4e-08 33.5 0.2 5.1e-08 33.2 0.2 1.3 1 1 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase PF00102.27 ELR23540.1 - 3.5e-06 26.8 0.0 3.9e-06 26.6 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase DSPc PF00782.20 ELR23540.1 - 5.2e-06 26.3 0.0 6.1e-06 26.1 0.0 1.1 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.6 ELR23540.1 - 0.00052 20.2 0.0 0.00066 19.8 0.0 1.1 1 0 0 1 1 1 1 Inositol hexakisphosphate Y_phosphatase2 PF03162.13 ELR23540.1 - 0.007 16.0 0.0 0.009 15.6 0.0 1.3 1 0 0 1 1 1 1 Tyrosine phosphatase family Amidohydro_1 PF01979.20 ELR23540.1 - 0.012 14.9 0.0 0.013 14.8 0.0 1.0 1 0 0 1 1 1 0 Amidohydrolase family Myotub-related PF06602.14 ELR23540.1 - 0.013 14.4 0.0 0.014 14.3 0.0 1.1 1 0 0 1 1 1 0 Myotubularin-like phosphatase domain DUF442 PF04273.13 ELR23540.1 - 0.029 14.4 0.0 0.049 13.7 0.0 1.4 1 1 0 1 1 1 0 Putative phosphatase (DUF442) CDKN3 PF05706.12 ELR23540.1 - 0.085 12.5 0.0 0.095 12.4 0.0 1.2 1 0 0 1 1 1 0 Cyclin-dependent kinase inhibitor 3 (CDKN3) LIG3_BRCT PF16759.5 ELR23540.1 - 0.12 12.7 0.0 0.2 12.0 0.0 1.3 1 0 0 1 1 1 0 DNA ligase 3 BRCT domain HRDC PF00570.23 ELR23540.1 - 0.27 11.2 1.6 7.3 6.7 0.1 2.9 3 0 0 3 3 3 0 HRDC domain Methyltr_RsmB-F PF01189.17 ELR23541.1 - 3.5e-33 114.9 0.0 8.2e-33 113.7 0.0 1.6 2 0 0 2 2 2 1 16S rRNA methyltransferase RsmB/F FtsJ PF01728.19 ELR23541.1 - 0.0098 16.0 0.0 0.016 15.3 0.0 1.4 1 0 0 1 1 1 1 FtsJ-like methyltransferase PKD_channel PF08016.12 ELR23542.1 - 1.2e-06 27.5 3.2 1.2e-06 27.5 3.2 2.0 3 0 0 3 3 3 1 Polycystin cation channel YL1 PF05764.13 ELR23542.1 - 0.00028 21.1 4.3 0.00028 21.1 4.3 2.3 2 0 0 2 2 2 1 YL1 nuclear protein EPL1 PF10513.9 ELR23542.1 - 0.00091 19.6 5.5 0.13 12.7 0.6 2.3 2 0 0 2 2 2 2 Enhancer of polycomb-like SR-25 PF10500.9 ELR23542.1 - 0.0037 16.9 37.8 0.048 13.3 15.6 2.3 2 0 0 2 2 2 2 Nuclear RNA-splicing-associated protein Macoilin PF09726.9 ELR23542.1 - 0.009 14.6 9.0 0.18 10.3 0.8 2.2 2 0 0 2 2 2 2 Macoilin family DUF5033 PF16436.5 ELR23542.1 - 0.069 13.1 0.1 0.13 12.2 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF5033) RP-C_C PF11800.8 ELR23542.1 - 0.13 12.3 8.3 2.6 8.1 2.0 2.5 2 0 0 2 2 2 0 Replication protein C C-terminal region SAPS PF04499.15 ELR23542.1 - 0.17 10.7 11.4 0.098 11.4 0.8 2.2 2 0 0 2 2 2 0 SIT4 phosphatase-associated protein Zip PF02535.22 ELR23542.1 - 0.31 10.2 10.8 0.16 11.1 0.1 2.5 2 0 0 2 2 2 0 ZIP Zinc transporter CDC45 PF02724.14 ELR23542.1 - 0.8 7.9 17.6 0.58 8.4 4.3 2.2 2 0 0 2 2 2 0 CDC45-like protein DUF3807 PF12720.7 ELR23542.1 - 2.4 8.4 23.5 3.3 8.0 7.8 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3807) Neur_chan_memb PF02932.16 ELR23542.1 - 3.6 7.6 6.8 34 4.4 0.1 2.6 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region LicD PF04991.13 ELR23542.1 - 6.3 6.9 8.4 2.6 8.1 0.9 2.5 2 0 0 2 2 2 0 LicD family Rtf2 PF04641.12 ELR23542.1 - 8.5 5.6 19.3 0.31 10.4 3.6 2.2 2 0 0 2 2 2 0 Rtf2 RING-finger ADC PF06314.11 ELR23543.1 - 6.9e-110 366.2 0.1 7.7e-67 225.3 0.0 2.1 2 0 0 2 2 2 2 Acetoacetate decarboxylase (ADC) DUF2071 PF09844.9 ELR23543.1 - 0.051 13.2 0.2 2 8.0 0.1 2.6 3 0 0 3 3 3 0 Uncharacterized conserved protein (COG2071) LRR_6 PF13516.6 ELR23544.1 - 9.7e-16 56.4 23.0 0.013 15.5 0.0 13.5 14 0 0 14 14 14 6 Leucine Rich repeat LRR_4 PF12799.7 ELR23544.1 - 7.9e-13 48.4 16.7 0.034 14.6 0.9 10.2 5 3 6 12 12 12 6 Leucine Rich repeats (2 copies) ASCH PF04266.14 ELR23544.1 - 6.6e-06 26.7 0.0 1.5e-05 25.5 0.0 1.6 1 0 0 1 1 1 1 ASCH domain LRR_1 PF00560.33 ELR23544.1 - 2.2e-05 24.4 21.2 8.2 7.4 0.0 12.9 17 0 0 17 17 17 1 Leucine Rich Repeat LRR_8 PF13855.6 ELR23544.1 - 0.0096 15.7 18.7 0.38 10.6 0.2 7.7 8 2 2 10 10 10 2 Leucine rich repeat RSN1_7TM PF02714.15 ELR23546.1 - 7.1e-65 219.0 23.7 1.7e-37 129.3 8.7 2.3 2 0 0 2 2 2 2 Calcium-dependent channel, 7TM region, putative phosphate PHM7_cyt PF14703.6 ELR23546.1 - 2.7e-35 122.2 0.9 4.1e-35 121.6 0.9 1.3 1 0 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter RSN1_TM PF13967.6 ELR23546.1 - 8.8e-26 90.5 3.8 8.8e-26 90.5 3.8 2.6 3 0 0 3 3 3 1 Late exocytosis, associated with Golgi transport AAA PF00004.29 ELR23547.1 - 5.5e-43 146.5 0.0 9.7e-43 145.8 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Vps4_C PF09336.10 ELR23547.1 - 5.4e-26 90.4 0.2 1.8e-25 88.7 0.2 2.0 1 0 0 1 1 1 1 Vps4 C terminal oligomerisation domain MIT PF04212.18 ELR23547.1 - 8.5e-22 77.0 9.3 2.2e-21 75.7 9.3 1.8 1 0 0 1 1 1 1 MIT (microtubule interacting and transport) domain AAA_16 PF13191.6 ELR23547.1 - 5e-06 27.0 0.3 0.0017 18.8 0.0 2.7 2 1 0 3 3 3 1 AAA ATPase domain RuvB_N PF05496.12 ELR23547.1 - 1.3e-05 25.0 0.0 2.6e-05 24.0 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain IstB_IS21 PF01695.17 ELR23547.1 - 3.3e-05 23.7 0.0 7.3e-05 22.6 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_5 PF07728.14 ELR23547.1 - 5.9e-05 23.1 0.0 0.00022 21.2 0.0 2.1 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 ELR23547.1 - 0.00017 21.9 1.8 0.0084 16.4 0.2 2.9 2 1 0 2 2 2 1 AAA domain AAA_18 PF13238.6 ELR23547.1 - 0.0002 21.9 0.0 0.0005 20.6 0.0 1.7 1 0 0 1 1 1 1 AAA domain DUF815 PF05673.13 ELR23547.1 - 0.00027 20.2 0.0 0.00057 19.1 0.0 1.5 1 1 0 1 1 1 1 Protein of unknown function (DUF815) AAA_14 PF13173.6 ELR23547.1 - 0.0011 19.0 0.0 0.004 17.2 0.0 1.9 2 0 0 2 2 2 1 AAA domain RNA_helicase PF00910.22 ELR23547.1 - 0.0012 19.2 0.0 0.0074 16.7 0.0 2.2 2 0 0 2 2 2 1 RNA helicase TIP49 PF06068.13 ELR23547.1 - 0.0014 17.9 0.0 0.0022 17.3 0.0 1.3 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_24 PF13479.6 ELR23547.1 - 0.0034 17.1 0.0 0.0096 15.7 0.0 1.8 1 1 0 1 1 1 1 AAA domain AAA_25 PF13481.6 ELR23547.1 - 0.0044 16.6 0.2 0.56 9.7 0.1 2.4 1 1 0 2 2 2 1 AAA domain AAA_33 PF13671.6 ELR23547.1 - 0.0057 16.8 0.0 0.016 15.4 0.0 1.8 1 0 0 1 1 1 1 AAA domain NACHT PF05729.12 ELR23547.1 - 0.021 14.8 0.0 0.68 9.8 0.0 2.4 1 1 1 2 2 2 0 NACHT domain AAA_2 PF07724.14 ELR23547.1 - 0.024 14.7 0.0 0.066 13.3 0.0 1.8 2 0 0 2 2 1 0 AAA domain (Cdc48 subfamily) TniB PF05621.11 ELR23547.1 - 0.036 13.5 0.0 8.8 5.7 0.0 2.6 2 0 0 2 2 2 0 Bacterial TniB protein PhoH PF02562.16 ELR23547.1 - 0.042 13.3 0.0 0.082 12.4 0.0 1.5 1 0 0 1 1 1 0 PhoH-like protein Mg_chelatase PF01078.21 ELR23547.1 - 0.045 13.1 0.0 0.081 12.3 0.0 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI KAP_NTPase PF07693.14 ELR23547.1 - 0.049 12.9 0.0 2.6 7.2 0.1 2.3 1 1 1 2 2 2 0 KAP family P-loop domain Bac_DnaA PF00308.18 ELR23547.1 - 0.054 13.3 0.0 0.43 10.4 0.0 2.3 2 1 0 2 2 2 0 Bacterial dnaA protein AAA_7 PF12775.7 ELR23547.1 - 0.054 13.0 0.0 0.19 11.2 0.0 1.9 1 1 0 1 1 1 0 P-loop containing dynein motor region AAA_17 PF13207.6 ELR23547.1 - 0.065 13.7 0.0 0.15 12.5 0.0 1.7 1 0 0 1 1 1 0 AAA domain Sigma54_activat PF00158.26 ELR23547.1 - 0.07 12.8 0.0 0.18 11.5 0.0 1.7 1 1 0 1 1 1 0 Sigma-54 interaction domain Parvo_NS1 PF01057.17 ELR23547.1 - 0.071 12.2 0.0 0.13 11.3 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 TPR_2 PF07719.17 ELR23547.1 - 0.11 12.6 0.6 0.57 10.4 0.6 2.4 1 0 0 1 1 1 0 Tetratricopeptide repeat ATPase_2 PF01637.18 ELR23547.1 - 0.12 12.3 1.2 1.6 8.6 0.0 2.5 2 1 0 3 3 3 0 ATPase domain predominantly from Archaea Zeta_toxin PF06414.12 ELR23547.1 - 0.14 11.5 0.1 1.5 8.1 0.0 2.2 1 1 1 2 2 2 0 Zeta toxin Viral_helicase1 PF01443.18 ELR23547.1 - 0.14 11.8 0.0 0.25 11.1 0.0 1.4 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase ATPase PF06745.13 ELR23547.1 - 0.18 11.1 0.1 7.9 5.7 0.0 2.3 1 1 1 2 2 2 0 KaiC BRO1 PF03097.18 ELR23547.1 - 0.22 10.3 2.1 0.34 9.7 2.1 1.2 1 0 0 1 1 1 0 BRO1-like domain EF-1_beta_acid PF10587.9 ELR23547.1 - 7.2 7.2 8.1 5.3 7.6 0.3 3.6 3 0 0 3 3 3 0 Eukaryotic elongation factor 1 beta central acidic region DUF5102 PF17104.5 ELR23548.1 - 0.079 13.0 0.9 0.11 12.5 0.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF5102) Zip PF02535.22 ELR23548.1 - 0.12 11.6 0.0 0.15 11.3 0.0 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Lin-8 PF03353.15 ELR23548.1 - 0.3 10.6 3.7 0.34 10.4 3.7 1.0 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist DUF4637 PF15470.6 ELR23548.1 - 4.2 7.1 7.6 5.5 6.7 7.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) PTPS PF01242.19 ELR23549.1 - 2.5e-34 117.9 0.1 3e-34 117.6 0.1 1.1 1 0 0 1 1 1 1 6-pyruvoyl tetrahydropterin synthase Rad51 PF08423.11 ELR23550.1 - 4.2e-124 412.9 0.1 6.6e-124 412.2 0.1 1.3 1 0 0 1 1 1 1 Rad51 RecA PF00154.21 ELR23550.1 - 3.6e-11 43.0 0.2 5e-11 42.6 0.2 1.1 1 0 0 1 1 1 1 recA bacterial DNA recombination protein AAA_25 PF13481.6 ELR23550.1 - 2.5e-09 37.0 0.0 4.1e-09 36.3 0.0 1.2 1 0 0 1 1 1 1 AAA domain ATPase PF06745.13 ELR23550.1 - 1.6e-06 27.6 0.1 2.9e-06 26.8 0.1 1.5 1 1 0 1 1 1 1 KaiC HHH_5 PF14520.6 ELR23550.1 - 2.8e-05 24.6 0.5 0.00011 22.8 0.5 2.0 2 0 0 2 2 2 1 Helix-hairpin-helix domain AAA_24 PF13479.6 ELR23550.1 - 0.0011 18.8 0.0 0.0028 17.4 0.0 1.7 1 1 0 1 1 1 1 AAA domain DnaB_C PF03796.15 ELR23550.1 - 0.043 13.1 0.4 0.15 11.3 0.2 2.0 1 1 1 2 2 2 0 DnaB-like helicase C terminal domain HHH PF00633.23 ELR23550.1 - 0.048 13.6 0.0 0.13 12.2 0.0 1.7 1 0 0 1 1 1 0 Helix-hairpin-helix motif AAA_22 PF13401.6 ELR23550.1 - 0.082 13.2 0.0 0.2 11.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain Etmic-2 PF06670.11 ELR23550.1 - 2.5 6.9 5.5 22 3.8 7.3 1.6 2 0 0 2 2 2 0 Microneme protein Etmic-2 Fz PF01392.22 ELR23551.1 - 5.4e-09 36.6 6.2 0.0004 21.0 0.5 2.4 2 1 0 2 2 2 2 Fz domain Mid1 PF12929.7 ELR23551.1 - 0.0049 16.1 0.5 0.0049 16.1 0.5 2.3 2 1 1 3 3 3 1 Stretch-activated Ca2+-permeable channel component PEP-CTERM PF07589.11 ELR23551.1 - 1 9.5 3.7 2.3 8.4 3.7 1.5 1 0 0 1 1 1 0 PEP-CTERM motif F-box-like PF12937.7 ELR23552.1 - 0.013 15.3 0.5 0.031 14.2 0.5 1.6 1 0 0 1 1 1 0 F-box-like F-box PF00646.33 ELR23552.1 - 0.044 13.7 0.8 0.09 12.7 0.8 1.5 1 0 0 1 1 1 0 F-box domain DUF1242 PF06842.12 ELR23553.1 - 1e-16 60.4 1.2 1.3e-16 60.1 0.5 1.5 2 0 0 2 2 2 1 Protein of unknown function (DUF1242) Mito_carr PF00153.27 ELR23554.1 - 2.6e-67 222.8 0.3 3.8e-23 81.2 0.1 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 ELR23554.1 - 0.0007 18.8 0.9 1.3 8.1 0.0 3.5 4 0 0 4 4 4 2 Gammaproteobacterial serine protease DSPc PF00782.20 ELR23555.1 - 3.1e-28 98.2 0.0 1.9e-17 63.3 0.0 2.5 2 0 0 2 2 2 2 Dual specificity phosphatase, catalytic domain HMG_box PF00505.19 ELR23555.1 - 1.9e-10 41.0 0.5 7.1e-10 39.2 0.5 2.0 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 ELR23555.1 - 2.2e-09 37.8 0.9 1.2e-08 35.5 0.9 2.3 1 0 0 1 1 1 1 HMG-box domain YL1 PF05764.13 ELR23555.1 - 0.00036 20.7 27.3 0.00036 20.7 27.3 5.4 3 2 2 5 5 5 1 YL1 nuclear protein SDA1 PF05285.12 ELR23555.1 - 0.0016 17.9 28.8 0.0016 17.9 28.8 4.3 4 0 0 4 4 4 1 SDA1 PTPlike_phytase PF14566.6 ELR23555.1 - 0.61 10.2 5.3 12 6.0 0.0 3.6 4 1 0 4 4 4 0 Inositol hexakisphosphate ADK PF00406.22 ELR23556.1 - 7e-26 91.1 0.0 1.1e-25 90.5 0.0 1.2 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 ELR23556.1 - 5e-18 65.8 0.0 1.1e-17 64.7 0.0 1.6 1 0 0 1 1 1 1 AAA domain mRNA_cap_enzyme PF01331.19 ELR23556.1 - 3.2e-14 53.2 0.0 5e-10 39.5 0.0 2.4 2 0 0 2 2 2 2 mRNA capping enzyme, catalytic domain ADK_lid PF05191.14 ELR23556.1 - 1.8e-12 47.0 0.1 1.8e-12 47.0 0.1 2.3 2 0 0 2 2 2 1 Adenylate kinase, active site lid DNA_ligase_A_M PF01068.21 ELR23556.1 - 1.1e-08 34.9 0.0 4.7e-08 32.9 0.0 2.0 2 0 0 2 2 2 1 ATP dependent DNA ligase domain AAA_33 PF13671.6 ELR23556.1 - 2.8e-07 30.8 0.0 6.2e-07 29.7 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 ELR23556.1 - 1.1e-05 26.0 0.0 3.4e-05 24.4 0.0 1.8 2 0 0 2 2 2 1 AAA domain Cytidylate_kin PF02224.18 ELR23556.1 - 0.0023 17.7 0.0 0.0039 17.0 0.0 1.3 1 0 0 1 1 1 1 Cytidylate kinase Zeta_toxin PF06414.12 ELR23556.1 - 0.06 12.6 0.0 0.18 11.1 0.0 1.7 1 1 0 1 1 1 0 Zeta toxin AAA_22 PF13401.6 ELR23556.1 - 0.18 12.1 0.0 0.33 11.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain Ins_P5_2-kin PF06090.12 ELR23557.1 - 2.1e-85 287.1 0.0 2.5e-85 286.8 0.0 1.1 1 0 0 1 1 1 1 Inositol-pentakisphosphate 2-kinase PPR_2 PF13041.6 ELR23558.1 - 3.6e-17 62.3 0.1 0.0044 17.2 0.0 5.8 5 1 1 6 6 5 5 PPR repeat family PPR PF01535.20 ELR23558.1 - 1.7e-15 56.1 1.9 7.8e-05 22.7 0.1 6.1 6 0 0 6 6 6 3 PPR repeat PPR_3 PF13812.6 ELR23558.1 - 1.1e-14 54.2 0.6 0.00035 20.6 0.3 5.4 4 1 1 5 5 5 4 Pentatricopeptide repeat domain PPR_long PF17177.4 ELR23558.1 - 3.9e-06 26.4 0.0 0.066 12.6 0.0 2.6 2 1 0 2 2 2 2 Pentacotripeptide-repeat region of PRORP PPR_1 PF12854.7 ELR23558.1 - 4.5e-06 26.3 1.4 0.0089 15.7 0.0 3.9 5 0 0 5 5 5 2 PPR repeat TPR_14 PF13428.6 ELR23558.1 - 4.5e-05 23.9 0.8 0.55 11.2 0.0 4.3 3 0 0 3 3 3 1 Tetratricopeptide repeat BTAD PF03704.17 ELR23558.1 - 0.00092 19.7 0.0 2.5 8.6 0.0 3.0 3 0 0 3 3 3 2 Bacterial transcriptional activator domain COX5A PF02284.16 ELR23558.1 - 0.0092 16.0 0.0 1.4 8.9 0.0 3.3 3 0 0 3 3 3 1 Cytochrome c oxidase subunit Va TPR_12 PF13424.6 ELR23558.1 - 0.023 15.0 1.3 0.94 9.8 0.0 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_8 PF13181.6 ELR23558.1 - 0.061 13.6 0.2 0.24 11.7 0.0 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_19 PF14559.6 ELR23558.1 - 0.069 13.7 0.3 2.3 8.8 0.0 3.2 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_7 PF13176.6 ELR23558.1 - 0.091 12.8 0.5 2.2 8.5 0.0 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_2 PF07719.17 ELR23558.1 - 0.16 12.1 0.4 1 9.7 0.1 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat Usp PF00582.26 ELR23559.1 - 7.9e-08 32.9 0.0 1.1e-07 32.5 0.0 1.2 1 0 0 1 1 1 1 Universal stress protein family Beach PF02138.18 ELR23561.1 - 1.3e-117 392.1 0.0 1.9e-117 391.5 0.0 1.3 1 0 0 1 1 1 1 Beige/BEACH domain PH_BEACH PF14844.6 ELR23561.1 - 2.1e-08 34.2 0.0 5.7e-08 32.8 0.0 1.9 1 0 0 1 1 1 1 PH domain associated with Beige/BEACH WD40 PF00400.32 ELR23561.1 - 6.5e-05 23.6 0.5 0.15 13.0 0.1 4.2 3 1 0 3 3 3 1 WD domain, G-beta repeat Laminin_G_3 PF13385.6 ELR23561.1 - 0.00041 20.5 0.0 0.0023 18.1 0.0 2.2 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily DUF4800 PF16057.5 ELR23561.1 - 0.003 16.9 0.3 0.003 16.9 0.3 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF4800) CDC14 PF08045.11 ELR23561.1 - 0.0078 15.4 0.1 0.021 14.0 0.1 1.7 1 0 0 1 1 1 1 Cell division control protein 14, SIN component V-ATPase_H_C PF11698.8 ELR23561.1 - 0.01 15.9 0.0 0.05 13.7 0.0 2.2 1 0 0 1 1 1 0 V-ATPase subunit H DIL PF01843.19 ELR23562.1 - 5.3e-21 74.8 0.1 1.4e-20 73.5 0.1 1.7 1 0 0 1 1 1 1 DIL domain SH3_1 PF00018.28 ELR23562.1 - 1e-05 25.0 0.1 3.5e-05 23.3 0.1 2.0 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 ELR23562.1 - 6.1e-05 22.6 0.0 0.0002 20.9 0.0 1.9 1 0 0 1 1 1 1 Variant SH3 domain NT-C2 PF10358.9 ELR23562.1 - 0.0004 20.1 0.5 0.0011 18.6 0.5 1.7 1 0 0 1 1 1 1 N-terminal C2 in EEIG1 and EHBP1 proteins SH3_9 PF14604.6 ELR23562.1 - 0.0013 18.6 0.1 0.0033 17.3 0.1 1.7 1 0 0 1 1 1 1 Variant SH3 domain Phage_lysis PF03245.13 ELR23562.1 - 0.019 15.1 9.0 0.052 13.7 8.5 2.1 1 1 0 1 1 1 0 Bacteriophage Rz lysis protein PspB PF06667.12 ELR23562.1 - 0.71 10.0 4.7 0.14 12.2 0.4 2.2 2 0 0 2 2 2 0 Phage shock protein B SlyX PF04102.12 ELR23562.1 - 6 7.6 10.4 8.9 7.0 4.8 3.2 2 0 0 2 2 2 0 SlyX GATA PF00320.27 ELR23564.1 - 9.9e-11 41.1 3.2 1.6e-10 40.4 3.2 1.3 1 0 0 1 1 1 1 GATA zinc finger ArfGap PF01412.18 ELR23564.1 - 0.063 13.4 0.2 0.093 12.8 0.2 1.3 1 0 0 1 1 1 0 Putative GTPase activating protein for Arf DUF2428 PF10350.9 ELR23565.1 - 6.3e-62 209.3 0.0 1.7e-61 207.9 0.0 1.8 1 0 0 1 1 1 1 Putative death-receptor fusion protein (DUF2428) HEAT PF02985.22 ELR23565.1 - 0.00021 21.3 4.7 0.61 10.5 0.1 6.6 7 0 0 7 7 7 1 HEAT repeat HEAT_2 PF13646.6 ELR23565.1 - 0.0048 17.2 9.5 0.7 10.3 0.2 5.7 6 0 0 6 6 6 1 HEAT repeats Cnd1 PF12717.7 ELR23565.1 - 0.013 15.5 0.4 28 4.7 0.0 4.2 5 0 0 5 5 5 0 non-SMC mitotic condensation complex subunit 1 Cyt-b5 PF00173.28 ELR23566.1 - 5.7e-21 74.4 0.0 7.9e-21 74.0 0.0 1.2 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain FHA PF00498.26 ELR23567.1 - 5.3e-13 49.1 0.0 1.1e-12 48.1 0.0 1.6 1 0 0 1 1 1 1 FHA domain zf-C3HC4 PF00097.25 ELR23567.1 - 4.6e-06 26.4 2.5 1e-05 25.3 2.5 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Yop-YscD_cpl PF16697.5 ELR23567.1 - 3.4e-05 24.1 1.2 0.00018 21.8 0.0 2.5 3 0 0 3 3 3 1 Inner membrane component of T3SS, cytoplasmic domain zf-C3HC4_2 PF13923.6 ELR23567.1 - 3.9e-05 23.4 4.3 8.1e-05 22.4 4.3 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 ELR23567.1 - 4.6e-05 23.5 1.4 0.00011 22.3 1.4 1.6 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.6 ELR23567.1 - 6.8e-05 22.8 1.7 0.00015 21.7 1.7 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 ELR23567.1 - 0.00019 21.2 1.4 0.00035 20.4 1.4 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ELR23567.1 - 0.00096 19.1 2.0 0.0025 17.7 2.0 1.7 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_2 PF13639.6 ELR23567.1 - 0.0019 18.5 3.6 0.004 17.5 3.6 1.6 1 0 0 1 1 1 1 Ring finger domain Prok-RING_4 PF14447.6 ELR23567.1 - 0.0089 15.9 1.7 0.019 14.8 1.7 1.6 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-rbx1 PF12678.7 ELR23567.1 - 0.038 14.3 0.9 0.085 13.2 0.9 1.6 1 0 0 1 1 1 0 RING-H2 zinc finger domain HMG_box PF00505.19 ELR23567.1 - 0.11 13.0 2.4 0.26 11.7 0.1 2.8 3 0 0 3 3 2 0 HMG (high mobility group) box zf-RING_6 PF14835.6 ELR23567.1 - 0.12 12.2 0.4 0.24 11.3 0.4 1.5 1 0 0 1 1 1 0 zf-RING of BARD1-type protein Vinculin PF01044.19 ELR23569.1 - 8.5e-31 107.1 150.0 4e-07 28.7 21.6 12.0 3 3 6 10 10 10 9 Vinculin family HLH PF00010.26 ELR23569.1 - 1.8 8.6 28.1 0.81 9.7 1.0 9.1 11 0 0 11 11 11 0 Helix-loop-helix DNA-binding domain F_actin_bind PF08919.10 ELR23569.1 - 4.7 7.3 25.0 0.54 10.4 0.2 8.4 8 1 1 9 9 9 0 F-actin binding Tam41_Mmp37 PF09139.11 ELR23570.1 - 2.8e-85 286.6 0.0 3.4e-85 286.3 0.0 1.1 1 0 0 1 1 1 1 Phosphatidate cytidylyltransferase, mitochondrial LIM PF00412.22 ELR23571.1 - 0.0058 16.8 0.2 0.0075 16.5 0.2 1.3 1 0 0 1 1 1 1 LIM domain LRR_4 PF12799.7 ELR23572.1 - 1.1e-09 38.5 14.7 0.00021 21.6 0.4 6.0 3 2 4 7 7 7 6 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 ELR23572.1 - 2.9e-08 33.1 18.4 0.1 12.7 0.0 6.8 8 0 0 8 8 8 4 Leucine Rich repeat LRR_8 PF13855.6 ELR23572.1 - 1.5e-05 24.6 15.3 0.023 14.5 0.2 5.6 1 1 3 6 6 6 3 Leucine rich repeat SLAIN PF15301.6 ELR23572.1 - 7.9e-05 22.1 0.1 0.00012 21.5 0.1 1.2 1 0 0 1 1 1 1 SLAIN motif-containing family F-box-like PF12937.7 ELR23572.1 - 0.0008 19.3 0.9 1.2 9.1 0.0 2.7 2 0 0 2 2 2 2 F-box-like FNIP PF05725.12 ELR23572.1 - 0.0018 18.4 10.1 0.65 10.2 0.1 5.1 4 2 0 4 4 4 2 FNIP Repeat F-box PF00646.33 ELR23572.1 - 0.046 13.6 0.6 1.4 8.8 0.0 2.8 2 0 0 2 2 2 0 F-box domain LRR_1 PF00560.33 ELR23572.1 - 0.092 13.3 14.5 5 8.1 0.0 5.6 5 2 0 5 5 5 0 Leucine Rich Repeat ParBc_2 PF08857.11 ELR23573.1 - 0.0026 17.9 0.0 0.0035 17.5 0.0 1.3 1 1 0 1 1 1 1 Putative ParB-like nuclease ParBc PF02195.18 ELR23573.1 - 0.026 14.8 0.4 0.052 13.9 0.4 1.7 1 1 0 1 1 1 0 ParB-like nuclease domain DUF1015 PF06245.11 ELR23573.1 - 0.063 12.1 0.1 0.077 11.8 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1015) PRK PF00485.18 ELR23574.1 - 0.0019 18.0 0.0 0.93 9.2 0.0 2.3 2 0 0 2 2 2 2 Phosphoribulokinase / Uridine kinase family TsaE PF02367.17 ELR23574.1 - 0.0061 16.6 0.0 0.0095 15.9 0.0 1.3 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE NUDE_C PF04880.13 ELR23574.1 - 0.033 14.7 0.6 0.05 14.1 0.6 1.3 1 0 0 1 1 1 0 NUDE protein, C-terminal conserved region AAA_23 PF13476.6 ELR23574.1 - 0.061 13.8 0.0 0.098 13.2 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 ELR23574.1 - 0.096 13.2 0.8 4.7 7.8 0.4 2.9 3 0 0 3 3 3 0 AAA domain MobB PF03205.14 ELR23574.1 - 0.17 11.8 0.2 0.84 9.5 0.2 2.0 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B Carn_acyltransf PF00755.20 ELR23575.1 - 2.2e-181 604.5 0.0 2.5e-181 604.3 0.0 1.0 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase zf-CCCH PF00642.24 ELR23576.1 - 1.5e-18 66.2 35.2 4.1e-05 23.4 1.0 5.5 4 1 1 5 5 5 5 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 ELR23576.1 - 1.7e-12 47.0 50.7 1.8e-06 27.8 2.0 6.7 7 0 0 7 7 7 4 Zinc finger domain zf-CCHC PF00098.23 ELR23576.1 - 3.3e-11 42.7 15.4 6.3e-07 29.2 2.6 3.4 3 0 0 3 3 3 2 Zinc knuckle Torus PF16131.5 ELR23576.1 - 8.2e-10 39.4 29.1 0.00044 20.9 0.7 5.2 1 1 4 5 5 5 4 Torus domain zf-CCCH_4 PF18044.1 ELR23576.1 - 1.3e-08 34.5 32.8 1.4e-05 24.8 0.3 4.8 5 0 0 5 5 5 3 CCCH-type zinc finger zf-CCHC_4 PF14392.6 ELR23576.1 - 1.4e-05 24.7 4.8 0.068 12.9 0.5 3.4 3 0 0 3 3 3 2 Zinc knuckle zf-CCHC_3 PF13917.6 ELR23576.1 - 2.3e-05 24.3 0.8 0.023 14.7 0.1 2.9 2 0 0 2 2 2 2 Zinc knuckle zf-CCCH_3 PF15663.5 ELR23576.1 - 2.9e-05 24.2 22.2 3.3e-05 24.0 11.8 3.0 1 1 2 3 3 3 1 Zinc-finger containing family zf-CCHC_6 PF15288.6 ELR23576.1 - 0.0048 16.7 15.1 0.044 13.6 1.7 3.5 4 0 0 4 4 4 2 Zinc knuckle eIF3g PF12353.8 ELR23576.1 - 0.008 16.6 2.4 0.46 10.9 0.3 2.3 2 0 0 2 2 2 1 Eukaryotic translation initiation factor 3 subunit G zf-CCCH_2 PF14608.6 ELR23576.1 - 0.28 11.7 42.9 0.19 12.2 3.2 6.3 6 0 0 6 6 6 0 RNA-binding, Nab2-type zinc finger C2 PF00168.30 ELR23577.1 - 6.5e-29 100.3 0.0 8.1e-29 99.9 0.0 1.1 1 0 0 1 1 1 1 C2 domain CEP76-C2 PF15627.6 ELR23577.1 - 0.016 14.8 0.0 0.019 14.5 0.0 1.2 1 0 0 1 1 1 0 CEP76 C2 domain GATA PF00320.27 ELR23578.1 - 1.2e-14 53.6 6.9 2.3e-14 52.7 6.9 1.5 1 0 0 1 1 1 1 GATA zinc finger DZR PF12773.7 ELR23578.1 - 0.047 13.7 0.5 0.14 12.2 0.6 1.7 1 1 0 1 1 1 0 Double zinc ribbon ADD_DNMT3 PF17980.1 ELR23578.1 - 0.1 12.6 0.1 0.18 11.8 0.1 1.3 1 0 0 1 1 1 0 Cysteine rich ADD domain in DNMT3 zf-NADH-PPase PF09297.11 ELR23578.1 - 0.16 11.6 3.1 1.6 8.4 0.4 2.6 2 0 0 2 2 2 0 NADH pyrophosphatase zinc ribbon domain OrfB_Zn_ribbon PF07282.11 ELR23578.1 - 0.46 10.5 1.6 1.1 9.2 1.6 1.6 1 0 0 1 1 1 0 Putative transposase DNA-binding domain PilJ PF13675.6 ELR23579.1 - 0.019 15.0 1.2 0.057 13.4 0.4 1.8 1 1 1 2 2 2 0 Type IV pili methyl-accepting chemotaxis transducer N-term DUF2205 PF10224.9 ELR23579.1 - 0.69 10.0 5.2 7.1 6.7 3.0 2.6 2 1 0 2 2 2 0 Short coiled-coil protein Pkinase_Tyr PF07714.17 ELR23580.1 - 1.3e-51 175.4 0.0 2.9e-51 174.2 0.0 1.6 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ELR23580.1 - 2.2e-42 145.3 2.6 2.6e-42 145.0 0.0 2.2 2 1 0 2 2 1 1 Protein kinase domain COR PF16095.5 ELR23580.1 - 1.2e-25 90.5 0.0 4.1e-19 69.2 0.0 2.4 2 0 0 2 2 2 2 C-terminal of Roc, COR, domain Roc PF08477.13 ELR23580.1 - 3.7e-11 43.3 1.8 1.5e-08 34.9 1.8 2.9 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 ELR23580.1 - 3.9e-08 33.1 0.4 2.5e-05 23.9 0.0 2.3 2 0 0 2 2 2 2 Ras family SR-25 PF10500.9 ELR23580.1 - 0.0034 17.0 19.8 0.0034 17.0 19.8 3.2 3 0 0 3 3 3 1 Nuclear RNA-splicing-associated protein EIF_2_alpha PF07541.12 ELR23580.1 - 0.0057 16.7 0.0 0.017 15.2 0.0 1.8 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 2 alpha subunit Arf PF00025.21 ELR23580.1 - 0.0077 15.7 0.1 2 7.8 0.1 2.5 2 0 0 2 2 2 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 ELR23580.1 - 0.032 14.3 0.1 0.4 10.8 0.0 2.9 2 1 0 2 2 2 0 50S ribosome-binding GTPase TniB PF05621.11 ELR23580.1 - 0.045 13.2 0.0 0.16 11.4 0.0 2.0 1 0 0 1 1 1 0 Bacterial TniB protein EIIBC-GUT_N PF03612.14 ELR23580.1 - 1.7 8.3 6.5 4.6 6.9 6.5 1.7 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus SLC12 PF03522.15 ELR23580.1 - 3.2 6.7 9.0 0.038 13.0 0.9 1.8 2 0 0 2 2 2 0 Solute carrier family 12 CotH PF08757.11 ELR23580.1 - 3.6 7.0 6.7 5.6 6.4 0.0 2.4 2 0 0 2 2 2 0 CotH kinase protein Connexin PF00029.19 ELR23580.1 - 5.3 6.7 6.3 14 5.4 6.3 1.6 1 0 0 1 1 1 0 Connexin CMS1 PF14617.6 ELR23580.1 - 6.6 6.0 20.5 0.5 9.7 0.3 2.4 2 0 0 2 2 2 0 U3-containing 90S pre-ribosomal complex subunit AP3D1 PF06375.11 ELR23580.1 - 9.2 6.5 24.8 2.8 8.2 15.9 2.4 2 0 0 2 2 2 0 AP-3 complex subunit delta-1 AAA PF00004.29 ELR23581.1 - 1.2e-17 64.5 0.0 3.3e-17 63.2 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 ELR23581.1 - 0.0032 17.9 0.2 0.017 15.5 0.1 2.1 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 ELR23581.1 - 0.0062 16.8 0.3 0.18 12.1 0.1 2.5 1 1 1 2 2 2 1 AAA domain AAA_5 PF07728.14 ELR23581.1 - 0.053 13.5 0.0 0.11 12.4 0.0 1.6 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_33 PF13671.6 ELR23581.1 - 0.14 12.3 0.0 0.32 11.1 0.0 1.6 1 0 0 1 1 1 0 AAA domain YL1 PF05764.13 ELR23581.1 - 2.2 8.3 8.9 4 7.5 8.9 1.3 1 0 0 1 1 1 0 YL1 nuclear protein Prok-RING_4 PF14447.6 ELR23583.1 - 0.0011 18.8 2.4 0.0019 18.0 2.4 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 Cnn_1N PF07989.11 ELR23583.1 - 0.0027 17.8 6.0 0.0027 17.8 6.0 2.6 2 1 1 3 3 3 1 Centrosomin N-terminal motif 1 KASH_CCD PF14662.6 ELR23583.1 - 0.012 15.4 16.7 0.012 15.4 16.7 2.0 1 1 1 2 2 2 0 Coiled-coil region of CCDC155 or KASH WDCP PF15390.6 ELR23583.1 - 0.078 11.3 3.5 0.12 10.8 3.5 1.1 1 0 0 1 1 1 0 WD repeat and coiled-coil-containing protein family zf-C3HC4_3 PF13920.6 ELR23583.1 - 0.36 10.7 4.2 1.4 8.9 4.2 1.9 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) K-box PF01486.17 ELR23583.1 - 2.3 8.5 19.9 0.14 12.3 7.0 3.4 1 1 2 3 3 3 0 K-box region LMBR1 PF04791.16 ELR23583.1 - 2.7 6.8 5.4 3.8 6.3 5.4 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein Sec2p PF06428.11 ELR23583.1 - 9.5 6.3 15.5 30 4.7 7.8 3.5 2 1 1 3 3 3 0 GDP/GTP exchange factor Sec2p Lyase_8 PF02278.18 ELR23585.1 - 0.072 12.5 0.5 0.081 12.4 0.5 1.0 1 0 0 1 1 1 0 Polysaccharide lyase family 8, super-sandwich domain Herpes_UL25 PF01499.16 ELR23585.1 - 0.24 9.9 6.0 0.27 9.7 6.0 1.0 1 0 0 1 1 1 0 Herpesvirus UL25 family YabA PF06156.13 ELR23585.1 - 3.1 8.5 5.2 16 6.2 5.2 1.9 1 1 0 1 1 1 0 Initiation control protein YabA V_ATPase_I PF01496.19 ELR23585.1 - 3.1 5.6 5.0 3.5 5.4 5.0 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family ubiquitin PF00240.23 ELR23586.1 - 2.5e-31 107.2 0.0 2.4e-20 72.0 0.0 4.2 4 0 0 4 4 4 3 Ubiquitin family Rad60-SLD PF11976.8 ELR23586.1 - 9.5e-14 51.0 0.0 2e-07 30.7 0.0 3.5 3 0 0 3 3 3 2 Ubiquitin-2 like Rad60 SUMO-like zf-RING_2 PF13639.6 ELR23586.1 - 4.6e-10 39.7 12.8 4.6e-10 39.7 12.8 2.5 2 0 0 2 2 2 1 Ring finger domain zf-rbx1 PF12678.7 ELR23586.1 - 3.1e-07 30.6 8.7 9e-07 29.1 8.7 1.8 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_11 PF17123.5 ELR23586.1 - 1.7e-05 24.5 10.0 4.1e-05 23.2 10.0 1.7 1 0 0 1 1 1 1 RING-like zinc finger Ubiquitin_2 PF14560.6 ELR23586.1 - 0.00089 19.7 0.0 0.42 11.1 0.0 3.1 3 0 0 3 3 3 1 Ubiquitin-like domain zf-C3HC4 PF00097.25 ELR23586.1 - 0.0024 17.7 12.8 0.0024 17.7 12.8 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 ELR23586.1 - 0.0047 16.7 12.7 0.0047 16.7 12.7 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 ELR23586.1 - 0.16 12.1 9.7 0.48 10.5 9.7 1.9 1 0 0 1 1 1 0 RING-type zinc-finger zf-C3HC4_3 PF13920.6 ELR23586.1 - 4.8 7.1 20.6 0.12 12.2 9.7 2.4 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) RRM_1 PF00076.22 ELR23587.1 - 1.6e-17 63.1 0.0 3.7e-17 61.9 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) eIF3g PF12353.8 ELR23587.1 - 4.9e-13 49.6 6.3 8.5e-13 48.8 6.3 1.4 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit G RRM_occluded PF16842.5 ELR23587.1 - 0.049 13.5 0.0 0.11 12.3 0.0 1.6 1 0 0 1 1 1 0 Occluded RNA-recognition motif P34-Arc PF04045.14 ELR23588.1 - 4.1e-82 275.5 0.1 5.5e-82 275.1 0.1 1.2 1 0 0 1 1 1 1 Arp2/3 complex, 34 kD subunit p34-Arc ARPC4 PF05856.12 ELR23588.1 - 0.00022 20.9 0.5 0.00049 19.8 0.5 1.5 1 1 0 1 1 1 1 ARP2/3 complex 20 kDa subunit (ARPC4) DUF4978 PF16349.5 ELR23588.1 - 0.044 13.4 0.2 8.4 6.0 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4978) Calici_coat PF00915.20 ELR23588.1 - 0.12 11.3 0.1 0.16 10.8 0.1 1.3 1 0 0 1 1 1 0 Calicivirus coat protein zf-MYND PF01753.18 ELR23589.1 - 1.1e-10 41.4 14.1 1.9e-10 40.6 14.1 1.4 1 0 0 1 1 1 1 MYND finger zf-C6H2 PF15801.5 ELR23589.1 - 0.86 10.0 12.0 1.7 9.0 12.0 1.5 1 0 0 1 1 1 0 zf-MYND-like zinc finger, mRNA-binding DUF5113 PF17140.4 ELR23590.1 - 0.13 12.1 0.0 0.19 11.5 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5113) Med24_N PF11277.8 ELR23591.1 - 1.8e-15 56.2 0.0 3.8e-12 45.2 0.0 2.4 2 0 0 2 2 2 2 Mediator complex subunit 24 N-terminal Ras PF00071.22 ELR23592.1 - 1.3e-48 164.6 0.1 1.6e-48 164.4 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR23592.1 - 5.9e-19 68.5 0.0 9.5e-19 67.8 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR23592.1 - 1.2e-12 47.6 0.0 1.3e-12 47.5 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 ELR23592.1 - 1.4e-05 24.8 0.1 0.00054 19.6 0.1 2.1 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 ELR23592.1 - 3.4e-05 23.9 0.0 0.00012 22.2 0.0 1.8 2 0 0 2 2 2 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 ELR23592.1 - 5.4e-05 23.2 1.4 0.1 12.5 0.0 2.6 1 1 0 2 2 2 2 RsgA GTPase Gtr1_RagA PF04670.12 ELR23592.1 - 0.00086 18.7 0.0 0.001 18.5 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.10 ELR23592.1 - 0.0033 16.9 0.0 0.0042 16.5 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit AIG1 PF04548.16 ELR23592.1 - 0.0076 15.6 0.0 0.011 15.0 0.0 1.2 1 0 0 1 1 1 1 AIG1 family G-alpha PF00503.20 ELR23592.1 - 0.045 12.9 0.0 0.15 11.2 0.0 1.5 1 1 1 2 2 2 0 G-protein alpha subunit AAA_33 PF13671.6 ELR23592.1 - 0.052 13.7 0.1 0.15 12.2 0.0 1.8 1 1 0 1 1 1 0 AAA domain ATP_bind_1 PF03029.17 ELR23592.1 - 0.057 13.2 0.4 1.1 8.9 0.0 2.1 1 1 1 2 2 2 0 Conserved hypothetical ATP binding protein AAA_16 PF13191.6 ELR23592.1 - 0.09 13.1 0.3 0.2 12.0 0.3 1.9 1 1 0 1 1 1 0 AAA ATPase domain ParA PF10609.9 ELR23592.1 - 0.11 12.0 0.0 0.2 11.1 0.0 1.4 1 0 0 1 1 1 0 NUBPL iron-transfer P-loop NTPase AAA_22 PF13401.6 ELR23592.1 - 0.12 12.7 0.1 2.3 8.5 0.1 2.2 1 1 1 2 2 2 0 AAA domain TFX_C PF14601.6 ELR23592.1 - 0.16 12.0 0.0 0.28 11.2 0.0 1.3 1 0 0 1 1 1 0 DNA_binding protein, TFX, C-term Usp PF00582.26 ELR23593.1 - 3.3e-25 89.2 0.6 4.3e-25 88.9 0.1 1.5 2 0 0 2 2 2 1 Universal stress protein family AcylCoA_dehyd_C PF12186.8 ELR23593.1 - 0.018 15.2 0.5 0.049 13.8 0.1 1.8 2 0 0 2 2 2 0 Acyl-CoA dehydrogenase C terminal SET PF00856.28 ELR23594.1 - 2e-14 54.4 0.0 5.9e-09 36.5 0.0 2.6 2 1 0 2 2 2 2 SET domain UCH_1 PF13423.6 ELR23595.1 - 5.6e-67 226.6 0.0 7.9e-67 226.1 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH PF00443.29 ELR23595.1 - 1.9e-07 30.9 0.0 1.1e-05 25.1 0.0 2.2 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase ADK_lid PF05191.14 ELR23595.1 - 0.0039 17.1 1.2 0.25 11.3 0.1 3.8 3 1 0 3 3 3 1 Adenylate kinase, active site lid ANAPC4_WD40 PF12894.7 ELR23595.1 - 0.051 13.9 0.0 10 6.5 0.0 3.4 2 2 2 4 4 4 0 Anaphase-promoting complex subunit 4 WD40 domain ABM PF03992.16 ELR23596.1 - 1.4e-16 60.3 0.1 1.7e-16 60.1 0.1 1.1 1 0 0 1 1 1 1 Antibiotic biosynthesis monooxygenase SBP_bac_11 PF13531.6 ELR23596.1 - 0.0067 16.2 0.1 0.0079 16.0 0.1 1.0 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein TGS PF02824.21 ELR23596.1 - 0.017 15.2 0.0 0.042 13.9 0.0 1.7 1 1 1 2 2 2 0 TGS domain RNase_T PF00929.24 ELR23597.1 - 4.4e-09 37.1 0.6 1.3e-06 29.0 0.0 3.0 2 1 0 2 2 2 1 Exonuclease RRM_1 PF00076.22 ELR23598.1 - 1.1e-16 60.4 0.0 2e-16 59.6 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SR-25 PF10500.9 ELR23598.1 - 0.0021 17.7 16.7 0.0021 17.7 16.7 3.2 2 1 1 3 3 3 1 Nuclear RNA-splicing-associated protein RRM_7 PF16367.5 ELR23598.1 - 0.076 13.1 0.0 0.19 11.9 0.0 1.7 1 0 0 1 1 1 0 RNA recognition motif DNA_pol_phi PF04931.13 ELR23598.1 - 1.3 7.1 12.0 2.4 6.2 12.0 1.4 1 0 0 1 1 1 0 DNA polymerase phi PAC1 PF16094.5 ELR23598.1 - 8.9 5.4 5.6 14 4.8 5.6 1.2 1 0 0 1 1 1 0 Proteasome assembly chaperone 4 FeS_assembly_P PF01883.19 ELR23599.1 - 2.3e-06 27.7 0.0 4.5e-06 26.7 0.0 1.5 2 0 0 2 2 2 1 Iron-sulfur cluster assembly protein Ras PF00071.22 ELR23600.1 - 1.5e-56 190.4 0.0 1.8e-56 190.2 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR23600.1 - 5.2e-20 71.9 0.0 7.6e-20 71.3 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR23600.1 - 9e-10 38.3 0.0 1.1e-09 38.0 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 ELR23600.1 - 1e-05 25.2 0.3 9.4e-05 22.0 0.0 2.0 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 ELR23600.1 - 2.2e-05 24.4 0.8 0.099 12.5 0.0 2.5 1 1 1 3 3 3 2 RsgA GTPase MMR_HSR1 PF01926.23 ELR23600.1 - 0.00023 21.2 0.0 0.00039 20.5 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase ATP_bind_1 PF03029.17 ELR23600.1 - 0.00062 19.6 0.2 0.08 12.7 0.0 2.1 1 1 1 2 2 2 1 Conserved hypothetical ATP binding protein G-alpha PF00503.20 ELR23600.1 - 0.017 14.3 0.0 1.2 8.2 0.0 2.1 1 1 0 2 2 2 0 G-protein alpha subunit FeoB_N PF02421.18 ELR23600.1 - 0.021 14.4 0.2 0.55 9.8 0.0 2.2 2 0 0 2 2 2 0 Ferrous iron transport protein B NB-ARC PF00931.22 ELR23600.1 - 0.071 12.3 0.0 0.12 11.5 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain Septin PF00735.18 ELR23600.1 - 0.1 11.8 0.0 0.19 11.0 0.0 1.5 1 0 0 1 1 1 0 Septin DUF2075 PF09848.9 ELR23600.1 - 0.11 11.8 0.4 5.7 6.1 0.1 2.0 1 1 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) AAA_16 PF13191.6 ELR23600.1 - 0.16 12.3 0.1 0.27 11.6 0.1 1.6 1 1 0 1 1 1 0 AAA ATPase domain LIN52 PF10044.9 ELR23601.1 - 4e-11 43.5 0.2 7.7e-11 42.6 0.2 1.6 1 1 0 1 1 1 1 Retinal tissue protein CHD5 PF04420.14 ELR23603.1 - 1.7e-14 53.9 0.5 2.7e-14 53.4 0.5 1.3 1 0 0 1 1 1 1 CHD5-like protein Patatin PF01734.22 ELR23604.1 - 7.4e-16 58.9 0.1 9.6e-15 55.3 0.1 2.6 1 1 0 1 1 1 1 Patatin-like phospholipase PH PF00169.29 ELR23604.1 - 1.4e-06 28.8 0.1 0.0072 16.8 0.2 3.2 2 1 0 2 2 2 2 PH domain F-box-like PF12937.7 ELR23605.1 - 3.3e-06 26.9 0.2 4.5e-06 26.5 0.2 1.2 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ELR23605.1 - 4.8e-05 23.1 0.2 6.7e-05 22.7 0.2 1.2 1 0 0 1 1 1 1 F-box domain AHD PF17793.1 ELR23606.1 - 0.063 13.1 0.0 0.095 12.5 0.0 1.3 1 0 0 1 1 1 0 ANC1 homology domain (AHD) LTV PF04180.14 ELR23607.1 - 1.3e-23 84.3 48.6 3e-11 43.7 0.2 4.2 1 1 3 4 4 4 3 Low temperature viability protein Exo_endo_phos PF03372.23 ELR23607.1 - 3.6e-10 39.8 0.1 7.8e-10 38.7 0.1 1.6 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Utp14 PF04615.13 ELR23607.1 - 7.7 5.0 45.9 5.5 5.4 23.4 2.1 2 0 0 2 2 2 0 Utp14 protein RRM_1 PF00076.22 ELR23608.1 - 1.8e-07 30.8 0.0 2.6e-06 27.2 0.0 2.2 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Haem_oxygenas_2 PF14518.6 ELR23609.1 - 3.5e-31 108.4 0.0 1.7e-30 106.1 0.0 2.2 1 0 0 1 1 1 1 Iron-containing redox enzyme DUF3446 PF11928.8 ELR23610.1 - 0.0023 18.2 10.3 0.0033 17.7 10.3 1.4 1 0 0 1 1 1 1 Early growth response N-terminal domain SR-25 PF10500.9 ELR23610.1 - 0.0029 17.2 6.8 0.003 17.2 6.8 1.1 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein Herpes_pp85 PF04637.12 ELR23610.1 - 1.6 7.0 5.3 1.8 6.9 5.3 1.1 1 0 0 1 1 1 0 Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25) RAP1 PF07218.11 ELR23610.1 - 5.9 5.0 5.7 5.9 5.0 5.7 1.0 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) ThiF PF00899.21 ELR23611.1 - 2.8e-97 324.9 0.0 1.7e-66 224.1 0.0 2.4 2 1 0 2 2 2 2 ThiF family UBA_e1_thiolCys PF10585.9 ELR23611.1 - 5.8e-82 275.4 7.0 1.1e-81 274.5 7.0 1.5 1 0 0 1 1 1 1 Ubiquitin-activating enzyme active site E1_FCCH PF16190.5 ELR23611.1 - 7.5e-28 96.5 1.7 1.1e-27 96.0 0.5 2.1 2 0 0 2 2 2 1 Ubiquitin-activating enzyme E1 FCCH domain E1_4HB PF16191.5 ELR23611.1 - 3.1e-23 81.7 0.2 8.9e-23 80.3 0.2 1.8 1 0 0 1 1 1 1 Ubiquitin-activating enzyme E1 four-helix bundle E1_UFD PF09358.10 ELR23611.1 - 3.7e-16 59.6 0.0 1.1e-15 58.1 0.0 1.9 1 0 0 1 1 1 1 Ubiquitin fold domain NAD_binding_7 PF13241.6 ELR23611.1 - 0.049 14.1 1.0 1.8 9.0 0.0 3.3 3 0 0 3 3 3 0 Putative NAD(P)-binding Metallophos PF00149.28 ELR23612.1 - 3.5e-18 66.9 0.0 1.1e-17 65.2 0.0 1.7 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase F-box-like PF12937.7 ELR23612.1 - 0.00084 19.2 4.2 0.0023 17.8 1.3 2.7 2 0 0 2 2 2 1 F-box-like DUF5378 PF17349.2 ELR23612.1 - 0.11 11.8 0.0 0.16 11.3 0.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5378) UCH PF00443.29 ELR23613.1 - 4.5e-21 75.5 0.0 2.9e-20 72.8 0.0 2.1 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 ELR23613.1 - 7.5e-08 32.3 1.0 1.7e-06 27.9 0.5 2.2 2 0 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase UBX PF00789.20 ELR23614.1 - 1.1e-12 48.0 0.0 2.8e-12 46.7 0.0 1.7 1 0 0 1 1 1 1 UBX domain DUF4628 PF15429.6 ELR23614.1 - 0.41 10.3 7.8 0.84 9.3 7.8 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4628) LRR_4 PF12799.7 ELR23615.1 - 2.7e-18 65.8 5.0 0.0044 17.4 0.1 7.0 5 2 2 7 7 7 7 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 ELR23615.1 - 1.5e-13 49.6 8.3 0.34 11.1 0.1 9.4 10 0 0 10 10 10 4 Leucine Rich repeat LRR_8 PF13855.6 ELR23615.1 - 7.5e-11 41.6 10.5 0.005 16.6 0.0 5.9 4 1 1 5 5 5 3 Leucine rich repeat LRR_1 PF00560.33 ELR23615.1 - 0.00086 19.5 2.0 1.1e+02 3.9 0.0 6.4 7 0 0 7 7 7 0 Leucine Rich Repeat LON_substr_bdg PF02190.16 ELR23616.1 - 2.2e-08 34.3 0.0 2.7e-08 34.0 0.0 1.1 1 0 0 1 1 1 1 ATP-dependent protease La (LON) substrate-binding domain Apidaecin PF00807.17 ELR23616.1 - 4.6 7.4 5.3 11 6.2 5.3 1.6 1 0 0 1 1 1 0 Apidaecin CBS PF00571.28 ELR23617.1 - 1.2e-29 102.5 0.2 1.5e-09 38.1 0.0 4.3 4 0 0 4 4 4 4 CBS domain TPR_12 PF13424.6 ELR23618.1 - 1.5e-14 54.1 3.7 0.00021 21.5 0.7 4.7 3 1 1 4 4 4 4 Tetratricopeptide repeat F-box-like PF12937.7 ELR23618.1 - 1.1e-05 25.2 0.8 3.9e-05 23.5 0.1 2.3 2 0 0 2 2 2 1 F-box-like TPR_10 PF13374.6 ELR23618.1 - 0.083 12.8 12.4 0.09 12.7 0.1 5.3 6 0 0 6 6 6 0 Tetratricopeptide repeat F-box PF00646.33 ELR23618.1 - 0.12 12.3 0.1 0.33 10.9 0.1 1.8 1 0 0 1 1 1 0 F-box domain TPR_1 PF00515.28 ELR23618.1 - 0.15 12.0 0.8 24 5.0 0.0 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_7 PF13176.6 ELR23618.1 - 0.28 11.3 10.8 2.5 8.3 0.0 4.8 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_2 PF07719.17 ELR23618.1 - 1.8 8.9 8.1 20 5.6 0.1 4.5 5 0 0 5 5 5 0 Tetratricopeptide repeat DUF1754 PF08555.10 ELR23619.1 - 8.6e-06 26.5 4.6 1.2e-05 26.0 4.6 1.2 1 0 0 1 1 1 1 Eukaryotic family of unknown function (DUF1754) Nop16 PF09420.10 ELR23619.1 - 0.012 15.7 2.0 0.014 15.4 2.0 1.1 1 0 0 1 1 1 0 Ribosome biogenesis protein Nop16 DNA_pol3_tau_4 PF12168.8 ELR23620.1 - 0.22 12.1 0.3 7.1 7.3 0.0 2.7 3 0 0 3 3 3 0 DNA polymerase III subunits tau domain IV DnaB-binding CHCH PF06747.13 ELR23621.1 - 0.00071 19.6 0.8 0.0012 18.9 0.8 1.4 1 0 0 1 1 1 1 CHCH domain Pet191_N PF10203.9 ELR23621.1 - 0.00085 19.6 2.2 0.0012 19.1 2.2 1.2 1 0 0 1 1 1 1 Cytochrome c oxidase assembly protein PET191 NDUF_B7 PF05676.13 ELR23621.1 - 0.054 13.2 1.1 0.079 12.7 1.1 1.2 1 0 0 1 1 1 0 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) LSM PF01423.22 ELR23622.1 - 5.2e-19 67.7 0.1 5.9e-19 67.5 0.1 1.0 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 ELR23622.1 - 0.00035 20.7 0.0 0.00039 20.5 0.0 1.2 1 0 0 1 1 1 1 Ataxin 2 SM domain LSM14 PF12701.7 ELR23622.1 - 0.1 12.7 0.1 0.11 12.6 0.1 1.2 1 0 0 1 1 1 0 Scd6-like Sm domain Fcf2 PF08698.11 ELR23623.1 - 6.2e-18 65.0 0.2 6.2e-18 65.0 0.2 2.0 2 1 0 2 2 2 1 Fcf2 pre-rRNA processing TPR_1 PF00515.28 ELR23624.1 - 3.7e-05 23.4 1.8 0.0043 16.8 0.0 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.17 ELR23624.1 - 0.00021 21.2 5.2 0.0017 18.3 0.2 3.7 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_8 PF13181.6 ELR23624.1 - 0.00022 21.2 2.7 0.003 17.6 0.1 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_7 PF13176.6 ELR23624.1 - 0.023 14.7 0.1 0.44 10.7 0.0 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_6 PF13174.6 ELR23624.1 - 0.023 15.3 0.2 0.16 12.7 0.0 2.6 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_14 PF13428.6 ELR23624.1 - 0.024 15.4 0.9 5.4 8.1 0.0 3.4 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_12 PF13424.6 ELR23624.1 - 0.03 14.6 1.2 2.9 8.2 0.2 3.2 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_19 PF14559.6 ELR23624.1 - 0.032 14.7 0.9 0.27 11.8 0.3 2.5 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF3147 PF11345.8 ELR23625.1 - 0.0002 21.7 20.6 0.0033 17.8 6.5 2.6 2 1 0 2 2 2 2 Protein of unknown function (DUF3147) 4HBT PF03061.22 ELR23626.1 - 4.4e-11 43.0 0.1 7.1e-06 26.3 0.0 2.3 2 0 0 2 2 2 2 Thioesterase superfamily FAD_binding_3 PF01494.19 ELR23627.1 - 3.5e-23 82.4 0.0 1.3e-14 54.3 0.0 2.0 2 0 0 2 2 2 2 FAD binding domain NAD_binding_8 PF13450.6 ELR23627.1 - 4.6e-08 33.2 0.1 1.4e-07 31.7 0.1 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 ELR23627.1 - 2.1e-05 24.3 0.3 9.9e-05 22.1 0.2 1.8 1 1 0 2 2 2 1 FAD dependent oxidoreductase SE PF08491.10 ELR23627.1 - 0.00018 20.7 0.0 0.0019 17.3 0.0 2.2 2 0 0 2 2 2 1 Squalene epoxidase Pyr_redox PF00070.27 ELR23627.1 - 0.00028 21.4 0.3 0.0016 19.0 0.1 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 ELR23627.1 - 0.00028 20.2 0.2 0.00089 18.6 0.2 1.5 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 ELR23627.1 - 0.00082 18.6 0.0 0.0012 18.1 0.0 1.3 1 0 0 1 1 1 1 Glucose inhibited division protein A FAD_binding_2 PF00890.24 ELR23627.1 - 0.0013 17.9 0.1 0.0057 15.8 0.1 1.8 2 0 0 2 2 2 1 FAD binding domain 3HCDH_N PF02737.18 ELR23627.1 - 0.0028 17.6 0.1 0.0056 16.6 0.1 1.5 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Lact-deh-memb PF09330.11 ELR23627.1 - 0.0048 16.3 0.1 0.0075 15.6 0.1 1.2 1 0 0 1 1 1 1 D-lactate dehydrogenase, membrane binding HI0933_like PF03486.14 ELR23627.1 - 0.0088 14.8 0.0 0.016 13.9 0.0 1.4 1 0 0 1 1 1 1 HI0933-like protein ApbA PF02558.16 ELR23627.1 - 0.0098 15.5 0.1 0.018 14.7 0.1 1.4 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA NAD_binding_2 PF03446.15 ELR23627.1 - 0.051 13.8 0.0 0.097 12.8 0.0 1.5 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase Shikimate_DH PF01488.20 ELR23627.1 - 0.066 13.3 0.1 0.16 12.0 0.1 1.6 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Thi4 PF01946.17 ELR23627.1 - 0.1 11.9 0.1 0.17 11.1 0.1 1.3 1 0 0 1 1 1 0 Thi4 family AlaDh_PNT_C PF01262.21 ELR23627.1 - 0.1 11.9 0.1 0.19 11.0 0.1 1.5 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain PKS_DE PF18369.1 ELR23627.1 - 0.12 13.0 0.1 0.24 12.0 0.1 1.6 1 0 0 1 1 1 0 Polyketide synthase dimerisation element domain NAD_Gly3P_dh_N PF01210.23 ELR23627.1 - 0.16 11.9 0.0 0.32 11.0 0.0 1.4 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus cobW PF02492.19 ELR23628.1 - 3.7e-49 166.7 0.1 7.3e-49 165.7 0.1 1.5 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain CobW_C PF07683.14 ELR23628.1 - 7.1e-19 67.5 0.1 1.3e-18 66.7 0.1 1.5 1 0 0 1 1 1 1 Cobalamin synthesis protein cobW C-terminal domain AAA_22 PF13401.6 ELR23628.1 - 0.0032 17.8 0.7 0.43 10.9 0.4 2.7 2 1 0 2 2 2 1 AAA domain RsgA_GTPase PF03193.16 ELR23628.1 - 0.028 14.3 0.1 1.6 8.6 0.0 2.5 2 0 0 2 2 2 0 RsgA GTPase TsaE PF02367.17 ELR23628.1 - 0.1 12.6 0.0 0.25 11.3 0.0 1.6 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_23 PF13476.6 ELR23628.1 - 0.12 12.9 0.2 0.32 11.5 0.2 1.7 1 0 0 1 1 1 0 AAA domain 2OG-FeII_Oxy_2 PF13532.6 ELR23630.1 - 3.8e-10 40.3 0.0 5.6e-10 39.7 0.0 1.2 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily TAFII55_N PF04658.13 ELR23631.1 - 4.5e-14 52.5 0.0 4.5e-14 52.5 0.0 2.5 4 0 0 4 4 4 1 TAFII55 protein conserved region FXR_C1 PF16096.5 ELR23631.1 - 0.26 11.5 10.3 1.3 9.3 0.9 3.0 3 0 0 3 3 3 0 Fragile X-related 1 protein C-terminal region 2 DUF4407 PF14362.6 ELR23631.1 - 3.7 6.8 26.9 0.47 9.7 6.3 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) RhoGAP PF00620.27 ELR23632.1 - 4.3e-28 98.1 0.2 4.3e-28 98.1 0.2 1.7 2 0 0 2 2 2 1 RhoGAP domain NTP_transf_2 PF01909.23 ELR23633.1 - 0.0004 20.6 0.0 0.0017 18.6 0.0 2.1 1 0 0 1 1 1 1 Nucleotidyltransferase domain Polbeta PF18765.1 ELR23633.1 - 0.0028 17.7 0.0 0.0086 16.1 0.0 1.8 1 0 0 1 1 1 1 Polymerase beta, Nucleotidyltransferase Gly_transf_sug PF04488.15 ELR23634.1 - 2.5e-09 37.6 0.0 6.7e-09 36.3 0.0 1.7 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif Glyco_transf_25 PF01755.17 ELR23634.1 - 0.00013 21.9 0.0 0.00022 21.2 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 25 (LPS biosynthesis protein) PAN_1 PF00024.26 ELR23634.1 - 0.0017 18.3 0.1 0.0035 17.3 0.1 1.5 1 0 0 1 1 1 1 PAN domain TcdA_TcdB PF12919.7 ELR23634.1 - 0.0033 16.8 0.0 0.005 16.2 0.0 1.1 1 0 0 1 1 1 1 TcdA/TcdB catalytic glycosyltransferase domain Caps_synth PF05704.12 ELR23634.1 - 0.004 16.6 0.0 0.0061 16.0 0.0 1.2 1 0 0 1 1 1 1 Capsular polysaccharide synthesis protein PAN_4 PF14295.6 ELR23634.1 - 0.014 15.3 4.9 0.032 14.1 4.9 1.6 1 0 0 1 1 1 0 PAN domain DUF3917 PF13055.6 ELR23635.1 - 0.61 10.6 4.1 1.6 9.2 2.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3917) ArAE_1 PF06081.11 ELR23635.1 - 7.1 6.8 10.2 0.19 11.9 1.0 2.7 3 0 0 3 3 3 0 Aromatic acid exporter family member 1 Peptidase_A22B PF04258.13 ELR23636.1 - 1.8e-62 211.4 26.2 2.4e-62 211.0 26.2 1.1 1 0 0 1 1 1 1 Signal peptide peptidase PsbL PF02419.17 ELR23636.1 - 0.29 11.1 6.3 2.9 8.0 2.3 3.0 2 0 0 2 2 2 0 PsbL protein CLU PF13236.6 ELR23637.1 - 1.1e-58 198.7 0.0 2e-58 197.9 0.0 1.4 1 0 0 1 1 1 1 Clustered mitochondria eIF3_p135 PF12807.7 ELR23637.1 - 4.6e-07 30.0 1.3 4.6e-07 30.0 1.3 3.9 4 0 0 4 4 3 1 Translation initiation factor eIF3 subunit 135 TPR_1 PF00515.28 ELR23637.1 - 0.00029 20.5 1.3 3.9 7.4 0.1 4.5 4 0 0 4 4 4 2 Tetratricopeptide repeat Arm PF00514.23 ELR23637.1 - 0.0012 18.8 0.1 0.19 11.8 0.0 3.7 4 0 0 4 4 4 1 Armadillo/beta-catenin-like repeat TPR_11 PF13414.6 ELR23637.1 - 0.0028 17.3 0.3 13 5.6 0.0 4.2 4 0 0 4 4 4 1 TPR repeat TPR_2 PF07719.17 ELR23637.1 - 0.0062 16.6 5.8 6 7.2 0.2 5.3 5 0 0 5 5 4 1 Tetratricopeptide repeat zf-RanBP PF00641.18 ELR23637.1 - 0.0072 15.6 4.5 0.016 14.5 4.5 1.5 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others TPR_19 PF14559.6 ELR23637.1 - 0.011 16.2 0.1 57 4.3 0.0 3.9 3 0 0 3 3 3 0 Tetratricopeptide repeat LRR_4 PF12799.7 ELR23637.1 - 0.013 16.0 6.0 0.93 10.0 0.3 5.0 3 1 2 5 5 5 0 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 ELR23637.1 - 0.018 15.0 14.2 0.17 12.0 0.1 5.4 7 0 0 7 7 7 0 Leucine Rich repeat TPR_14 PF13428.6 ELR23637.1 - 0.022 15.5 0.6 19 6.4 0.0 4.9 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_12 PF13424.6 ELR23637.1 - 0.036 14.4 0.0 18 5.7 0.0 3.9 3 0 0 3 3 3 0 Tetratricopeptide repeat ABC_tran PF00005.27 ELR23638.1 - 2.9e-23 82.9 0.0 4.6e-23 82.3 0.0 1.3 1 0 0 1 1 1 1 ABC transporter ABC2_membrane PF01061.24 ELR23638.1 - 4.9e-18 65.3 5.8 6.9e-18 64.8 5.8 1.2 1 0 0 1 1 1 1 ABC-2 type transporter RsgA_GTPase PF03193.16 ELR23638.1 - 0.0023 17.8 0.0 0.0047 16.9 0.0 1.4 1 0 0 1 1 1 1 RsgA GTPase AAA_25 PF13481.6 ELR23638.1 - 0.012 15.1 0.1 0.036 13.6 0.1 1.8 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.6 ELR23638.1 - 0.017 14.9 0.2 0.049 13.4 0.2 1.8 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_21 PF13304.6 ELR23638.1 - 0.019 14.8 0.0 5.5 6.7 0.0 2.2 2 0 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_22 PF13401.6 ELR23638.1 - 0.03 14.6 0.0 0.097 12.9 0.0 1.8 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.6 ELR23638.1 - 0.036 14.4 0.1 0.097 13.1 0.1 1.7 1 0 0 1 1 1 0 AAA ATPase domain SMC_N PF02463.19 ELR23638.1 - 0.21 11.0 0.1 8.5 5.7 0.1 2.2 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain FGGY_N PF00370.21 ELR23639.1 - 2e-43 148.7 0.0 3.9e-42 144.5 0.0 2.6 2 1 0 2 2 2 1 FGGY family of carbohydrate kinases, N-terminal domain FGGY_C PF02782.16 ELR23639.1 - 7.9e-41 140.0 0.1 1e-39 136.3 0.1 2.2 2 0 0 2 2 2 1 FGGY family of carbohydrate kinases, C-terminal domain FHA PF00498.26 ELR23639.1 - 2.1e-17 63.2 0.0 4.7e-17 62.1 0.0 1.7 1 0 0 1 1 1 1 FHA domain Yop-YscD_cpl PF16697.5 ELR23639.1 - 1.6e-07 31.5 0.0 0.0093 16.3 0.0 2.6 2 0 0 2 2 2 2 Inner membrane component of T3SS, cytoplasmic domain HSP70 PF00012.20 ELR23639.1 - 0.011 13.9 0.2 0.048 11.9 0.0 1.8 2 0 0 2 2 2 0 Hsp70 protein Miff PF05644.11 ELR23639.1 - 0.074 12.7 0.1 0.12 12.0 0.1 1.2 1 0 0 1 1 1 0 Mitochondrial and peroxisomal fission factor Mff SUR7 PF06687.12 ELR23640.1 - 0.00017 21.3 8.2 0.00017 21.3 8.2 3.6 3 1 1 4 4 4 2 SUR7/PalI family Tweety PF04906.13 ELR23640.1 - 0.00034 19.4 18.4 0.014 14.1 2.3 2.4 1 1 1 2 2 2 2 Tweety DUF948 PF06103.11 ELR23640.1 - 1.2 9.4 5.4 1.2 9.4 0.1 3.5 4 0 0 4 4 4 0 Bacterial protein of unknown function (DUF948) TIM21 PF08294.11 ELR23640.1 - 6.5 6.6 5.2 2.8 7.8 0.1 2.8 3 0 0 3 3 3 0 TIM21 BTB PF00651.31 ELR23641.1 - 4.6e-17 62.2 2.2 4e-08 33.5 0.0 4.4 3 1 0 3 3 3 3 BTB/POZ domain tRNA_edit PF04073.15 ELR23641.1 - 3.1e-07 30.5 0.0 1.1e-06 28.7 0.0 1.9 1 1 0 1 1 1 1 Aminoacyl-tRNA editing domain BACK PF07707.15 ELR23641.1 - 5.1e-05 23.3 0.0 0.00023 21.2 0.0 2.2 3 0 0 3 3 3 1 BTB And C-terminal Kelch Mucin PF01456.17 ELR23641.1 - 7.1 6.6 12.3 5.5 7.0 2.1 2.4 2 0 0 2 2 2 0 Mucin-like glycoprotein Ank_4 PF13637.6 ELR23642.1 - 0.00014 22.4 0.2 0.097 13.3 0.1 3.7 2 1 0 2 2 2 1 Ankyrin repeats (many copies) Ank_5 PF13857.6 ELR23642.1 - 0.029 14.7 0.5 27 5.2 0.0 3.8 4 1 1 5 5 5 0 Ankyrin repeats (many copies) AMP-binding PF00501.28 ELR23643.1 - 1.8e-56 191.6 0.1 2.5e-42 145.0 0.0 2.2 1 1 1 2 2 2 2 AMP-binding enzyme AMP-binding_C PF13193.6 ELR23643.1 - 9.8e-09 36.1 0.1 2.2e-08 35.0 0.1 1.6 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain MFS_1 PF07690.16 ELR23644.1 - 4.5e-54 183.7 34.0 1.1e-45 156.1 20.4 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 ELR23644.1 - 1.8e-10 40.3 10.7 3.4e-10 39.4 10.4 1.5 1 1 0 1 1 1 1 Sugar (and other) transporter Nuc_H_symport PF03825.16 ELR23644.1 - 2.2e-05 23.7 7.1 2.2e-05 23.7 7.1 2.3 2 1 0 2 2 2 1 Nucleoside H+ symporter OATP PF03137.20 ELR23644.1 - 7e-05 21.3 4.9 0.003 15.9 4.8 2.2 1 1 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family MFS_1_like PF12832.7 ELR23644.1 - 0.0024 16.8 8.6 0.0024 16.8 8.6 2.5 1 1 0 2 2 2 1 MFS_1 like family MFS_2 PF13347.6 ELR23644.1 - 0.0067 15.0 23.6 0.0051 15.4 11.6 2.8 2 1 0 2 2 2 2 MFS/sugar transport protein MFS_3 PF05977.13 ELR23644.1 - 0.4 9.0 27.4 0.053 11.9 4.2 3.9 2 2 1 3 3 3 0 Transmembrane secretion effector C9orf72-like PF15019.6 ELR23645.1 - 5.7e-36 124.3 0.1 4e-34 118.3 0.1 2.2 1 1 0 1 1 1 1 C9orf72-like protein family Phage_holin_3_6 PF07332.11 ELR23645.1 - 0.22 11.5 5.9 4.6 7.3 0.0 2.8 3 0 0 3 3 3 0 Putative Actinobacterial Holin-X, holin superfamily III Abhydrolase_1 PF00561.20 ELR23646.1 - 3.1e-08 33.6 0.0 4.9e-08 32.9 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 ELR23646.1 - 1.6e-05 25.7 3.6 2.7e-05 24.9 3.6 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 ELR23646.1 - 0.00053 19.3 0.0 0.0015 17.8 0.0 1.7 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Esterase_phd PF10503.9 ELR23646.1 - 0.0033 17.0 0.0 2.2 7.7 0.0 2.4 2 0 0 2 2 2 2 Esterase PHB depolymerase Peptidase_S9 PF00326.21 ELR23646.1 - 0.11 11.9 1.3 7.3 6.0 0.0 2.6 3 0 0 3 3 3 0 Prolyl oligopeptidase family tRNA-synt_1g PF09334.11 ELR23647.1 - 1.9e-104 349.6 0.0 2.5e-104 349.2 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (M) tRNA-synt_1 PF00133.22 ELR23647.1 - 1.8e-24 85.9 2.6 7.2e-12 44.3 0.6 3.4 3 1 0 3 3 3 2 tRNA synthetases class I (I, L, M and V) tRNA-synt_1e PF01406.19 ELR23647.1 - 1.6e-12 47.4 0.0 2.8e-05 23.6 0.0 2.1 2 0 0 2 2 2 2 tRNA synthetases class I (C) catalytic domain Anticodon_1 PF08264.13 ELR23647.1 - 3.2e-06 27.2 0.0 6.8e-06 26.1 0.0 1.5 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1f PF01921.18 ELR23647.1 - 0.0018 17.3 0.0 0.059 12.3 0.0 2.2 2 0 0 2 2 2 1 tRNA synthetases class I (K) Aha1_N PF09229.11 ELR23648.1 - 7.7e-35 120.1 0.3 1.3e-34 119.3 0.3 1.3 1 0 0 1 1 1 1 Activator of Hsp90 ATPase, N-terminal AHSA1 PF08327.11 ELR23648.1 - 2.7e-24 85.8 2.3 3.8e-23 82.1 0.2 2.7 2 1 0 2 2 2 1 Activator of Hsp90 ATPase homolog 1-like protein Aminotran_3 PF00202.21 ELR23649.1 - 1.4e-89 300.6 0.0 1.7e-89 300.3 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III Abhydrolase_1 PF00561.20 ELR23650.1 - 3e-11 43.4 1.6 2.1e-10 40.7 0.1 2.6 3 1 0 3 3 3 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 ELR23650.1 - 3.8e-09 36.2 0.0 2.2e-08 33.7 0.0 1.9 1 1 1 2 2 2 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 ELR23650.1 - 1.8e-08 35.3 0.0 2.8e-08 34.7 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S15 PF02129.18 ELR23650.1 - 1.1e-05 25.2 4.2 8.7e-05 22.2 4.1 2.2 1 1 0 1 1 1 1 X-Pro dipeptidyl-peptidase (S15 family) Peptidase_S9 PF00326.21 ELR23650.1 - 0.0014 18.2 0.0 0.0028 17.2 0.0 1.5 1 0 0 1 1 1 1 Prolyl oligopeptidase family DLH PF01738.18 ELR23650.1 - 0.0053 16.3 0.1 0.016 14.8 0.1 1.8 1 1 0 1 1 1 1 Dienelactone hydrolase family SelP_N PF04592.14 ELR23650.1 - 0.83 9.0 10.1 1.7 8.0 10.1 1.5 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Aminotran_5 PF00266.19 ELR23651.1 - 5.5e-12 45.3 0.0 7.2e-12 44.9 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-V Aminotran_3 PF00202.21 ELR23651.1 - 0.017 13.8 0.0 0.028 13.1 0.0 1.2 1 0 0 1 1 1 0 Aminotransferase class-III SecE PF00584.20 ELR23652.1 - 0.025 14.5 0.1 0.14 12.1 0.1 2.4 1 0 0 1 1 1 0 SecE/Sec61-gamma subunits of protein translocation complex DUF3040 PF11239.8 ELR23652.1 - 6.6 7.1 9.8 0.94 9.8 0.1 3.9 3 1 0 3 3 3 0 Protein of unknown function (DUF3040) AAA PF00004.29 ELR23653.1 - 1.3e-48 164.8 0.0 6.4e-41 139.9 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) Bromodomain PF00439.25 ELR23653.1 - 1.3e-15 57.2 0.1 3.4e-15 55.9 0.1 1.7 1 0 0 1 1 1 1 Bromodomain AAA_lid_3 PF17862.1 ELR23653.1 - 5.8e-11 42.0 1.4 1.8e-10 40.5 0.0 2.4 2 0 0 2 2 2 1 AAA+ lid domain IstB_IS21 PF01695.17 ELR23653.1 - 1.5e-07 31.4 0.0 1.1e-06 28.5 0.0 2.3 2 0 0 2 2 2 1 IstB-like ATP binding protein AAA_16 PF13191.6 ELR23653.1 - 2.4e-06 28.0 0.0 7.4e-05 23.2 0.0 3.2 3 0 0 3 3 2 1 AAA ATPase domain AAA_2 PF07724.14 ELR23653.1 - 1.5e-05 25.2 0.0 8.1e-05 22.8 0.0 2.3 1 1 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_5 PF07728.14 ELR23653.1 - 0.00042 20.3 0.0 0.0022 18.0 0.0 2.3 2 1 0 2 2 1 1 AAA domain (dynein-related subfamily) Parvo_NS1 PF01057.17 ELR23653.1 - 0.0018 17.5 0.0 0.041 13.0 0.0 2.2 2 0 0 2 2 2 1 Parvovirus non-structural protein NS1 AAA_18 PF13238.6 ELR23653.1 - 0.0057 17.2 0.0 0.016 15.8 0.0 1.8 1 0 0 1 1 1 1 AAA domain RNA_helicase PF00910.22 ELR23653.1 - 0.0057 17.0 0.0 0.028 14.8 0.0 2.2 3 0 0 3 3 1 1 RNA helicase AAA_22 PF13401.6 ELR23653.1 - 0.017 15.4 3.9 0.39 11.0 0.6 4.0 3 2 0 3 3 3 0 AAA domain Mg_chelatase PF01078.21 ELR23653.1 - 0.018 14.5 0.0 0.036 13.5 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_25 PF13481.6 ELR23653.1 - 0.021 14.4 0.3 0.18 11.3 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_30 PF13604.6 ELR23653.1 - 0.023 14.4 0.1 0.085 12.6 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_28 PF13521.6 ELR23653.1 - 0.032 14.5 0.3 0.22 11.7 0.0 2.5 2 0 0 2 2 2 0 AAA domain RuvB_N PF05496.12 ELR23653.1 - 0.037 13.8 0.0 0.14 11.9 0.0 2.0 1 1 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain Sigma54_activat PF00158.26 ELR23653.1 - 0.039 13.7 0.0 1.6 8.4 0.0 2.9 3 0 0 3 3 3 0 Sigma-54 interaction domain AAA_7 PF12775.7 ELR23653.1 - 0.043 13.3 0.0 0.19 11.3 0.0 2.0 3 0 0 3 3 3 0 P-loop containing dynein motor region TIP49 PF06068.13 ELR23653.1 - 0.077 12.2 0.0 0.15 11.3 0.0 1.3 1 0 0 1 1 1 0 TIP49 P-loop domain NACHT PF05729.12 ELR23653.1 - 0.086 12.8 2.0 0.47 10.4 0.2 2.9 3 1 0 3 3 3 0 NACHT domain ATPase PF06745.13 ELR23653.1 - 0.096 12.0 0.0 0.23 10.8 0.0 1.6 1 0 0 1 1 1 0 KaiC Sigma54_activ_2 PF14532.6 ELR23653.1 - 0.11 12.6 0.0 0.65 10.1 0.0 2.1 2 0 0 2 2 2 0 Sigma-54 interaction domain SOG2 PF10428.9 ELR23653.1 - 1.4 8.0 10.3 2.4 7.2 10.3 1.3 1 0 0 1 1 1 0 RAM signalling pathway protein PARM PF17061.5 ELR23653.1 - 3.5 7.7 25.7 6.5 6.8 25.7 1.3 1 0 0 1 1 1 0 PARM Ecl1 PF12855.7 ELR23653.1 - 5.6 8.1 16.2 5.9 8.0 14.5 1.8 2 0 0 2 2 1 0 ECL1/2/3 zinc binding proteins DUF2981 PF11200.8 ELR23653.1 - 8.2 6.1 6.3 14 5.3 6.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2981) LRR_6 PF13516.6 ELR23655.1 - 2.2e-36 120.8 17.8 0.0014 18.5 0.1 16.4 17 1 0 17 17 17 9 Leucine Rich repeat LRR_4 PF12799.7 ELR23655.1 - 5.2e-20 71.2 25.9 0.014 15.8 0.0 11.2 8 3 1 10 10 10 7 Leucine Rich repeats (2 copies) F-box-like PF12937.7 ELR23655.1 - 5e-09 35.9 0.7 5e-09 35.9 0.7 2.8 3 0 0 3 3 3 1 F-box-like F-box PF00646.33 ELR23655.1 - 1.6e-08 34.2 2.0 6.9e-08 32.2 0.2 3.1 2 1 1 3 3 3 1 F-box domain LRR_1 PF00560.33 ELR23655.1 - 1.1e-05 25.3 42.2 4.3 8.3 1.4 13.4 11 3 1 12 12 12 2 Leucine Rich Repeat LRR_8 PF13855.6 ELR23655.1 - 6.4e-05 22.6 28.5 0.015 15.1 1.6 8.7 6 2 5 11 11 11 4 Leucine rich repeat RhoGAP PF00620.27 ELR23656.1 - 9.4e-30 103.4 0.1 1.9e-19 70.0 0.0 2.7 1 1 1 2 2 2 2 RhoGAP domain SH3_2 PF07653.17 ELR23656.1 - 4.9e-05 22.9 0.2 8.5e-05 22.2 0.2 1.4 1 0 0 1 1 1 1 Variant SH3 domain Tim54 PF11711.8 ELR23656.1 - 0.0099 14.7 0.5 0.02 13.7 0.5 1.4 1 0 0 1 1 1 1 Inner membrane protein import complex subunit Tim54 SH3_1 PF00018.28 ELR23656.1 - 0.076 12.6 0.2 0.2 11.3 0.2 1.7 1 1 0 1 1 1 0 SH3 domain NARP1 PF12569.8 ELR23656.1 - 0.098 11.5 6.2 0.16 10.8 6.2 1.2 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 Ferlin_C PF16165.5 ELR23656.1 - 0.11 12.5 1.7 0.2 11.6 1.7 1.4 1 0 0 1 1 1 0 Ferlin C-terminus SH3_9 PF14604.6 ELR23656.1 - 0.11 12.4 0.0 0.23 11.3 0.0 1.4 1 0 0 1 1 1 0 Variant SH3 domain DUF4407 PF14362.6 ELR23656.1 - 0.13 11.6 0.9 0.21 10.9 0.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Mito_carr PF00153.27 ELR23657.1 - 4.4e-66 218.9 0.4 1.1e-20 73.3 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein TAT_signal PF10518.9 ELR23657.1 - 0.2 11.5 0.3 0.2 11.5 0.3 3.2 3 0 0 3 3 3 0 TAT (twin-arginine translocation) pathway signal sequence CCDC84 PF14968.6 ELR23658.1 - 5.6e-12 45.9 2.7 6.6e-12 45.7 2.7 1.0 1 0 0 1 1 1 1 Coiled coil protein 84 2OG-FeII_Oxy_2 PF13532.6 ELR23659.1 - 1.8e-22 80.5 0.0 2.1e-22 80.3 0.0 1.1 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Pkinase PF00069.25 ELR23660.1 - 4.2e-50 170.5 0.0 1.3e-29 103.4 0.0 2.4 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ELR23660.1 - 9.7e-39 133.2 0.0 3.5e-19 69.1 0.0 2.4 1 1 1 2 2 2 2 Protein tyrosine kinase Rootletin PF15035.6 ELR23660.1 - 0.0028 17.7 4.1 0.0056 16.7 4.1 1.4 1 0 0 1 1 1 1 Ciliary rootlet component, centrosome cohesion Fib_alpha PF08702.10 ELR23660.1 - 0.1 12.8 2.8 0.13 12.4 1.0 2.1 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family Lzipper-MIP1 PF14389.6 ELR23660.1 - 0.23 11.8 8.0 1.1 9.5 7.4 2.3 1 1 0 1 1 1 0 Leucine-zipper of ternary complex factor MIP1 DUF1129 PF06570.11 ELR23660.1 - 0.7 9.3 3.3 1.3 8.4 3.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1129) DUF4407 PF14362.6 ELR23660.1 - 1.7 7.9 4.7 2.7 7.2 4.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF4140 PF13600.6 ELR23660.1 - 1.8 9.0 6.8 1.4 9.4 1.7 2.8 2 1 1 3 3 3 0 N-terminal domain of unknown function (DUF4140) Peptidase_M16_C PF05193.21 ELR23661.1 - 4.4e-34 118.1 1.1 2.2e-18 67.0 0.0 3.9 3 1 0 3 3 3 2 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 ELR23661.1 - 8.7e-23 81.0 0.0 1.9e-19 70.1 0.1 2.7 2 0 0 2 2 2 2 Insulinase (Peptidase family M16) CDC45 PF02724.14 ELR23661.1 - 0.0018 16.7 42.6 0.018 13.4 17.7 2.2 2 0 0 2 2 2 2 CDC45-like protein PPP4R2 PF09184.11 ELR23661.1 - 0.1 12.1 50.3 0.27 10.8 13.5 2.4 2 0 0 2 2 2 0 PPP4R2 Cnd2 PF05786.14 ELR23661.1 - 0.76 8.4 34.1 0.21 10.2 10.0 2.2 2 0 0 2 2 2 0 Condensin complex subunit 2 DDHD PF02862.17 ELR23661.1 - 2.3 8.3 9.4 0.21 11.7 1.2 2.4 2 0 0 2 2 2 0 DDHD domain PNISR PF15996.5 ELR23661.1 - 3.8 7.7 36.3 0.16 12.2 11.4 2.7 2 0 0 2 2 2 0 Arginine/serine-rich protein PNISR F-box-like PF12937.7 ELR23662.1 - 1.8e-07 31.0 1.4 4.2e-07 29.7 1.4 1.7 1 0 0 1 1 1 1 F-box-like Arf PF00025.21 ELR23662.1 - 0.029 13.8 0.0 1.2 8.6 0.0 2.8 1 1 0 1 1 1 0 ADP-ribosylation factor family SRPRB PF09439.10 ELR23662.1 - 0.03 13.7 0.0 0.059 12.8 0.0 1.4 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit F-box PF00646.33 ELR23662.1 - 0.083 12.8 0.2 0.24 11.3 0.2 1.8 1 0 0 1 1 1 0 F-box domain Proteasome PF00227.26 ELR23664.1 - 2.3e-48 164.2 0.7 3.7e-48 163.5 0.0 1.6 2 0 0 2 2 2 1 Proteasome subunit Proteasome_A_N PF10584.9 ELR23664.1 - 2.6e-13 49.4 0.2 4.7e-13 48.5 0.2 1.5 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature CoA_trans PF01144.23 ELR23665.1 - 0.13 11.6 0.2 0.39 10.1 0.2 1.7 2 0 0 2 2 2 0 Coenzyme A transferase Mis12 PF05859.12 ELR23666.1 - 3.2e-28 98.5 2.9 3.4e-28 98.4 0.7 1.9 1 1 2 3 3 3 1 Mis12 protein HALZ PF02183.18 ELR23666.1 - 7.4e-05 22.9 9.7 0.064 13.5 3.2 2.7 2 0 0 2 2 2 2 Homeobox associated leucine zipper bZIP_2 PF07716.15 ELR23666.1 - 0.0037 17.3 13.7 0.03 14.4 1.3 3.2 3 0 0 3 3 3 2 Basic region leucine zipper bZIP_1 PF00170.21 ELR23666.1 - 0.0041 17.2 11.7 0.059 13.5 0.9 3.1 2 1 1 3 3 3 2 bZIP transcription factor DUF3450 PF11932.8 ELR23666.1 - 0.006 15.9 5.1 0.01 15.1 5.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3450) Cnn_1N PF07989.11 ELR23666.1 - 0.032 14.4 11.1 0.48 10.6 1.7 3.2 1 1 1 2 2 2 0 Centrosomin N-terminal motif 1 Exonuc_VII_L PF02601.15 ELR23666.1 - 0.033 13.8 2.1 0.041 13.4 2.1 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit Not3 PF04065.15 ELR23666.1 - 0.084 12.3 4.7 0.053 13.0 2.7 1.6 2 0 0 2 2 2 0 Not1 N-terminal domain, CCR4-Not complex component Lge1 PF11488.8 ELR23666.1 - 0.11 12.7 3.7 0.15 12.3 1.2 2.4 2 1 0 2 2 2 0 Transcriptional regulatory protein LGE1 DUF2570 PF10828.8 ELR23666.1 - 0.12 12.2 1.4 0.22 11.3 1.4 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2570) hDGE_amylase PF14701.6 ELR23666.1 - 0.13 11.4 1.3 0.16 11.0 1.3 1.1 1 0 0 1 1 1 0 Glycogen debranching enzyme, glucanotransferase domain Fungal_TACC PF12709.7 ELR23666.1 - 0.14 12.6 0.7 0.14 12.6 0.7 2.6 1 1 1 2 2 2 0 Fungal Transforming acidic coiled-coil (TACC) proteins DivIC PF04977.15 ELR23666.1 - 0.26 11.1 13.4 0.57 10.0 2.0 2.6 1 1 1 2 2 2 0 Septum formation initiator FlaC_arch PF05377.11 ELR23666.1 - 0.44 11.0 9.5 0.31 11.5 0.4 3.2 2 1 1 3 3 3 0 Flagella accessory protein C (FlaC) E2F_CC-MB PF16421.5 ELR23666.1 - 0.52 10.7 5.7 4.3 7.8 0.5 2.7 3 0 0 3 3 2 0 E2F transcription factor CC-MB domain YabA PF06156.13 ELR23666.1 - 0.55 10.9 10.4 0.4 11.3 4.0 2.7 2 1 1 3 3 3 0 Initiation control protein YabA THOC7 PF05615.13 ELR23666.1 - 0.92 9.8 9.6 15 5.9 9.6 2.4 1 1 0 1 1 1 0 Tho complex subunit 7 Cep57_CLD_2 PF14197.6 ELR23666.1 - 1.5 8.9 15.6 2 8.5 6.1 3.2 3 0 0 3 3 3 0 Centrosome localisation domain of PPC89 GIT_CC PF16559.5 ELR23666.1 - 3.5 7.6 7.7 0.59 10.0 2.3 2.5 2 1 1 3 3 3 0 GIT coiled-coil Rho guanine nucleotide exchange factor ZapB PF06005.12 ELR23666.1 - 3.6 8.1 17.7 9.1 6.8 14.5 2.9 2 1 0 2 2 2 0 Cell division protein ZapB DUF465 PF04325.13 ELR23666.1 - 3.9 7.6 8.5 0.33 11.0 1.7 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF465) APG6_N PF17675.1 ELR23666.1 - 4.6 7.8 13.8 6.3 7.3 12.1 2.1 1 1 1 2 2 2 0 Apg6 coiled-coil region NYD-SP28_assoc PF14775.6 ELR23666.1 - 4.9 7.3 7.1 18 5.5 0.7 3.2 3 0 0 3 3 3 0 Sperm tail C-terminal domain LPP PF04728.13 ELR23666.1 - 5.1 7.6 6.7 20 5.6 3.8 2.5 2 0 0 2 2 2 0 Lipoprotein leucine-zipper F-box-like PF12937.7 ELR23667.1 - 6.2e-06 26.0 0.6 6.2e-06 26.0 0.6 1.7 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 ELR23667.1 - 9e-05 22.3 0.2 0.0002 21.2 0.2 1.6 1 0 0 1 1 1 1 F-box domain WD40 PF00400.32 ELR23667.1 - 0.00074 20.3 14.3 1.2 10.2 0.1 4.7 4 1 0 4 4 4 3 WD domain, G-beta repeat ANAPC4 PF12896.7 ELR23670.1 - 4.8e-41 140.5 3.7 7.4e-41 139.9 3.7 1.3 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 4 ANAPC4_WD40 PF12894.7 ELR23670.1 - 1.1e-28 99.3 0.1 2.8e-28 98.1 0.1 1.7 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 ELR23670.1 - 0.0073 17.1 0.8 0.086 13.7 0.1 3.0 2 0 0 2 2 2 1 WD domain, G-beta repeat IKI3 PF04762.12 ELR23670.1 - 0.042 11.8 0.3 0.79 7.6 0.0 2.4 2 1 1 3 3 3 0 IKI3 family TAF4 PF05236.14 ELR23670.1 - 0.3 10.8 2.5 0.67 9.6 2.5 1.5 1 0 0 1 1 1 0 Transcription initiation factor TFIID component TAF4 family Paf1 PF03985.13 ELR23670.1 - 7.3 5.5 11.8 0.091 11.7 1.4 2.2 2 0 0 2 2 2 0 Paf1 ASF1_hist_chap PF04729.13 ELR23671.1 - 2e-67 226.0 0.1 2.5e-67 225.6 0.1 1.1 1 0 0 1 1 1 1 ASF1 like histone chaperone Mpp10 PF04006.12 ELR23671.1 - 0.34 9.3 16.2 0.43 9.0 16.2 1.1 1 0 0 1 1 1 0 Mpp10 protein BUD22 PF09073.10 ELR23671.1 - 0.89 8.8 11.9 1.1 8.6 11.9 1.1 1 0 0 1 1 1 0 BUD22 Nop14 PF04147.12 ELR23671.1 - 1.7 6.7 19.3 2 6.5 19.3 1.0 1 0 0 1 1 1 0 Nop14-like family CDC45 PF02724.14 ELR23671.1 - 4.6 5.4 13.8 5.5 5.2 13.8 1.1 1 0 0 1 1 1 0 CDC45-like protein NOA36 PF06524.12 ELR23671.1 - 5.9 6.1 15.0 7.3 5.8 15.0 1.2 1 0 0 1 1 1 0 NOA36 protein Sld5 PF05916.11 ELR23672.1 - 0.00058 20.3 0.2 0.0011 19.4 0.2 1.6 1 1 0 1 1 1 1 GINS complex protein KH_6 PF15985.5 ELR23673.1 - 2.3e-17 63.1 0.4 4.8e-17 62.0 0.0 1.8 2 0 0 2 2 2 1 KH domain Rrp40_N PF18311.1 ELR23673.1 - 0.00077 19.3 0.2 0.003 17.4 0.0 1.9 2 0 0 2 2 2 1 Exosome complex exonuclease Rrp40 N-terminal domain JAB PF01398.21 ELR23674.1 - 1.5e-32 112.1 0.0 2.6e-32 111.3 0.0 1.4 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease MitMem_reg PF13012.6 ELR23674.1 - 1e-14 54.9 0.5 2.2e-14 53.8 0.5 1.5 1 0 0 1 1 1 1 Maintenance of mitochondrial structure and function Prok-JAB PF14464.6 ELR23674.1 - 1e-05 25.3 0.0 2.9e-05 23.8 0.0 1.7 1 1 1 2 2 2 1 Prokaryotic homologs of the JAB domain WD40 PF00400.32 ELR23675.1 - 4e-16 59.1 1.9 0.01 16.7 0.0 6.9 7 0 0 7 7 7 5 WD domain, G-beta repeat Lactonase PF10282.9 ELR23675.1 - 6.7e-05 22.3 0.0 0.00016 21.1 0.0 1.6 1 0 0 1 1 1 1 Lactonase, 7-bladed beta-propeller Ge1_WD40 PF16529.5 ELR23675.1 - 0.00036 19.6 0.0 0.026 13.5 0.0 2.6 2 1 0 2 2 2 1 WD40 region of Ge1, enhancer of mRNA-decapping protein ANAPC4_WD40 PF12894.7 ELR23675.1 - 0.026 14.8 0.0 26 5.2 0.0 3.7 2 1 2 4 4 4 0 Anaphase-promoting complex subunit 4 WD40 domain RR_TM4-6 PF06459.12 ELR23675.1 - 0.17 11.7 5.2 0.34 10.7 5.2 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 CDC45 PF02724.14 ELR23675.1 - 0.58 8.4 6.0 1.1 7.5 6.0 1.4 1 0 0 1 1 1 0 CDC45-like protein Homeodomain PF00046.29 ELR23676.1 - 9.2e-19 67.0 2.6 2e-18 66.0 2.6 1.6 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 ELR23676.1 - 0.014 15.3 0.3 0.042 13.8 0.3 1.8 1 0 0 1 1 1 0 Homeobox KN domain AC_N PF16214.5 ELR23676.1 - 2.6 7.1 5.1 1.6 7.8 3.1 1.5 1 1 0 1 1 1 0 Adenylyl cyclase N-terminal extracellular and transmembrane region Y_phosphatase PF00102.27 ELR23678.1 - 2.9e-70 236.5 0.0 3.5e-70 236.2 0.0 1.0 1 0 0 1 1 1 1 Protein-tyrosine phosphatase DSPc PF00782.20 ELR23678.1 - 0.0002 21.2 0.0 0.0004 20.2 0.0 1.6 1 1 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 ELR23678.1 - 0.00064 19.8 0.1 0.0011 19.0 0.0 1.6 2 0 0 2 2 2 1 Tyrosine phosphatase family PTPlike_phytase PF14566.6 ELR23678.1 - 0.044 13.9 0.0 0.12 12.5 0.0 1.8 1 0 0 1 1 1 0 Inositol hexakisphosphate EHN PF06441.12 ELR23679.1 - 3.9e-37 126.9 0.2 6.4e-37 126.2 0.2 1.3 1 0 0 1 1 1 1 Epoxide hydrolase N terminus Abhydrolase_1 PF00561.20 ELR23679.1 - 1.8e-15 57.3 0.0 3.3e-15 56.5 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 ELR23679.1 - 2.6e-05 24.9 0.8 0.00078 20.1 0.0 2.1 2 0 0 2 2 2 1 Alpha/beta hydrolase family FAM91_C PF14648.6 ELR23680.1 - 4.2e-128 427.9 0.0 5.8e-128 427.4 0.0 1.1 1 0 0 1 1 1 1 FAM91 C-terminus FAM91_N PF14647.6 ELR23680.1 - 3.2e-124 414.2 0.5 4.4e-124 413.8 0.5 1.2 1 0 0 1 1 1 1 FAM91 N-terminus FHA_2 PF17913.1 ELR23681.1 - 1.8e-05 24.9 0.0 3.9e-05 23.8 0.0 1.5 1 0 0 1 1 1 1 FHA domain FHA PF00498.26 ELR23681.1 - 0.0025 18.1 0.0 0.0043 17.4 0.0 1.4 1 0 0 1 1 1 1 FHA domain PUA_3 PF17785.1 ELR23681.1 - 0.06 13.2 0.1 0.39 10.5 0.0 2.3 2 0 0 2 2 2 0 PUA-like domain TrkA_C PF02080.21 ELR23681.1 - 0.073 12.9 0.1 0.14 12.0 0.1 1.4 1 0 0 1 1 1 0 TrkA-C domain 14-3-3 PF00244.20 ELR23682.1 - 2.6e-68 229.8 1.5 3.2e-68 229.6 1.5 1.0 1 0 0 1 1 1 1 14-3-3 protein HBM PF16591.5 ELR23682.1 - 0.019 14.4 0.1 0.092 12.2 0.0 1.9 2 0 0 2 2 2 0 Helical bimodular sensor domain RhoGEF67_u2 PF16614.5 ELR23682.1 - 0.063 13.4 0.1 0.14 12.2 0.0 1.6 2 0 0 2 2 2 0 Unstructured region two on RhoGEF 6 and 7 WD40 PF00400.32 ELR23683.1 - 1.2e-22 79.8 3.5 7e-07 29.9 0.1 6.1 6 0 0 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ELR23683.1 - 3.1e-19 69.1 0.7 0.00038 20.7 0.0 5.1 1 1 5 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 ELR23683.1 - 3e-09 37.0 0.5 0.0002 21.3 0.1 2.6 1 1 0 2 2 2 2 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 ELR23683.1 - 0.00015 21.2 0.0 0.0092 15.3 0.0 2.1 2 0 0 2 2 2 1 WD40-like domain PD40 PF07676.12 ELR23683.1 - 0.0066 16.4 0.1 0.32 11.0 0.0 3.3 4 0 0 4 4 4 1 WD40-like Beta Propeller Repeat Nup160 PF11715.8 ELR23683.1 - 0.0069 15.1 0.6 0.032 12.9 0.1 2.1 2 1 1 3 3 3 1 Nucleoporin Nup120/160 IKI3 PF04762.12 ELR23683.1 - 0.0076 14.3 0.1 0.41 8.6 0.0 2.6 2 1 1 3 3 3 2 IKI3 family Cytochrom_D1 PF02239.16 ELR23683.1 - 0.011 14.2 0.0 0.16 10.4 0.0 2.1 1 1 0 1 1 1 0 Cytochrome D1 heme domain DPPIV_N PF00930.21 ELR23683.1 - 0.13 11.0 0.2 16 4.1 0.0 2.9 2 1 1 3 3 3 0 Dipeptidyl peptidase IV (DPP IV) N-terminal region Thg1 PF04446.12 ELR23684.1 - 9.6e-21 74.1 0.0 1.7e-20 73.3 0.0 1.4 1 0 0 1 1 1 1 tRNAHis guanylyltransferase Bac_DNA_binding PF00216.21 ELR23684.1 - 0.055 13.7 0.1 0.11 12.7 0.1 1.4 1 0 0 1 1 1 0 Bacterial DNA-binding protein EF-hand_7 PF13499.6 ELR23685.1 - 2.1e-25 88.9 15.1 1.7e-11 44.4 3.6 2.7 2 1 2 4 4 4 3 EF-hand domain pair EF-hand_1 PF00036.32 ELR23685.1 - 3.5e-24 82.5 6.9 1.2e-07 30.8 1.5 4.3 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.6 ELR23685.1 - 4.9e-22 75.9 4.6 2.9e-06 26.8 1.5 4.3 4 0 0 4 4 4 3 EF-hand domain EF-hand_5 PF13202.6 ELR23685.1 - 1.5e-20 71.6 8.1 3.9e-06 26.1 0.1 3.7 3 0 0 3 3 3 3 EF hand EF-hand_8 PF13833.6 ELR23685.1 - 4.4e-16 58.5 6.4 2.9e-06 27.0 0.1 3.2 3 0 0 3 3 3 3 EF-hand domain pair EF-hand_9 PF14658.6 ELR23685.1 - 0.00018 21.8 0.1 0.033 14.5 0.0 3.0 3 1 0 3 3 3 1 EF-hand domain EF-hand_4 PF12763.7 ELR23685.1 - 0.00053 19.9 1.1 1.1 9.2 0.0 3.1 1 1 2 3 3 3 1 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 ELR23685.1 - 0.0015 18.8 0.8 0.94 9.8 0.1 3.3 2 1 0 3 3 3 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_10 PF14788.6 ELR23685.1 - 0.0099 15.7 3.3 1 9.3 0.3 2.9 2 1 1 3 3 3 2 EF hand DUF45 PF01863.17 ELR23685.1 - 0.032 14.3 0.0 0.22 11.6 0.0 2.0 1 1 0 1 1 1 0 Protein of unknown function DUF45 CCD48 PF15799.5 ELR23685.1 - 0.032 12.5 0.3 4.1 5.6 0.2 2.5 1 1 1 2 2 2 0 Coiled-coil domain-containing protein 48 Caleosin PF05042.13 ELR23685.1 - 0.039 13.9 1.3 0.45 10.4 0.1 2.7 2 1 0 2 2 2 0 Caleosin related protein RST PF12174.8 ELR23685.1 - 0.048 13.6 0.0 2.1 8.3 0.0 2.3 2 0 0 2 2 2 0 RCD1-SRO-TAF4 (RST) plant domain DUF1048 PF06304.11 ELR23685.1 - 0.064 13.7 0.1 0.9 10.0 0.0 2.5 2 1 1 3 3 3 0 Protein of unknown function (DUF1048) Phytochelatin PF05023.14 ELR23686.1 - 1.4e-87 292.4 0.0 1.7e-87 292.1 0.0 1.1 1 0 0 1 1 1 1 Phytochelatin synthase Peptidase_C39_2 PF13529.6 ELR23686.1 - 0.0046 17.5 0.1 0.067 13.7 0.1 2.1 1 1 0 1 1 1 1 Peptidase_C39 like family DHHC PF01529.20 ELR23687.1 - 1.1e-08 35.3 14.7 1.1e-06 28.7 5.8 2.7 2 1 1 3 3 3 2 DHHC palmitoyltransferase PTPLA PF04387.14 ELR23688.1 - 3.6e-62 209.0 8.6 3.6e-62 209.0 8.6 1.5 2 0 0 2 2 2 1 Protein tyrosine phosphatase-like protein, PTPLA SlyX PF04102.12 ELR23689.1 - 0.003 18.1 15.7 0.0089 16.6 0.9 3.6 1 1 1 2 2 2 2 SlyX DUF16 PF01519.16 ELR23689.1 - 0.18 12.3 12.2 0.38 11.3 0.5 2.6 1 1 2 3 3 3 0 Protein of unknown function DUF16 XhlA PF10779.9 ELR23689.1 - 0.51 10.6 7.5 0.82 9.9 0.0 3.2 2 1 1 3 3 3 0 Haemolysin XhlA Tweety PF04906.13 ELR23689.1 - 0.56 8.8 3.8 0.7 8.5 3.8 1.2 1 0 0 1 1 1 0 Tweety DUF2570 PF10828.8 ELR23689.1 - 0.97 9.3 11.5 8.9 6.2 0.2 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF2570) SKA1 PF07160.12 ELR23689.1 - 1.8 8.4 16.1 0.88 9.4 12.3 1.8 1 1 1 2 2 2 0 Spindle and kinetochore-associated protein 1 Fib_alpha PF08702.10 ELR23689.1 - 2.2 8.5 10.1 5.3 7.2 0.3 2.6 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family V_ATPase_I PF01496.19 ELR23689.1 - 3.1 5.6 11.4 4 5.2 11.4 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family TRAF_BIRC3_bd PF16673.5 ELR23689.1 - 4.1 7.3 11.0 0.89 9.4 1.5 3.1 2 2 1 3 3 3 0 TNF receptor-associated factor BIRC3 binding domain Ribosomal_60s PF00428.19 ELR23689.1 - 8.2 7.1 16.2 1.1 9.9 10.2 2.2 1 1 1 2 2 2 0 60s Acidic ribosomal protein TauE PF01925.19 ELR23690.1 - 5.2e-36 124.5 36.7 1.2e-35 123.3 36.8 1.5 1 1 0 1 1 1 1 Sulfite exporter TauE/SafE AAR2 PF05282.11 ELR23691.1 - 4.5e-89 299.3 0.0 5.3e-89 299.1 0.0 1.0 1 0 0 1 1 1 1 AAR2 protein RRM_1 PF00076.22 ELR23692.1 - 3.7e-30 103.5 0.1 1.5e-16 60.0 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 ELR23692.1 - 0.0014 18.7 0.0 3.1 8.0 0.0 2.7 2 0 0 2 2 2 2 RNA recognition motif FmdE PF02663.14 ELR23692.1 - 0.033 14.2 0.0 0.033 14.2 0.0 3.5 2 2 0 2 2 2 0 FmdE, Molybdenum formylmethanofuran dehydrogenase operon Macoilin PF09726.9 ELR23692.1 - 0.073 11.6 27.8 0.089 11.3 27.8 1.1 1 0 0 1 1 1 0 Macoilin family RRM_Rrp7 PF17799.1 ELR23692.1 - 0.081 12.7 0.0 0.081 12.7 0.0 2.5 3 1 0 3 3 3 0 Rrp7 RRM-like N-terminal domain DUF348 PF03990.14 ELR23692.1 - 0.18 11.6 1.1 9.3 6.1 0.0 3.1 3 0 0 3 3 3 0 G5-linked-Ubiquitin-like domain Nop14 PF04147.12 ELR23692.1 - 0.69 8.0 52.8 0.95 7.6 52.8 1.1 1 0 0 1 1 1 0 Nop14-like family Bax1-I PF01027.20 ELR23693.1 - 5.4e-40 137.4 24.3 6.2e-40 137.2 24.3 1.0 1 0 0 1 1 1 1 Inhibitor of apoptosis-promoting Bax1 DUF1765 PF08578.10 ELR23694.1 - 1.1e-23 84.1 7.9 2.3e-23 83.0 7.9 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1765) MBOAT PF03062.19 ELR23695.1 - 7.6e-42 143.9 5.4 1.3e-41 143.2 4.4 1.6 1 1 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family DUF702 PF05142.12 ELR23696.1 - 0.0059 17.1 8.3 0.0059 17.1 8.3 2.2 2 1 1 3 3 3 1 Domain of unknown function (DUF702) Sec2p PF06428.11 ELR23696.1 - 0.041 13.9 0.0 0.088 12.8 0.0 1.6 1 0 0 1 1 1 0 GDP/GTP exchange factor Sec2p FIN1 PF17300.2 ELR23696.1 - 0.044 13.3 0.0 0.088 12.3 0.0 1.5 1 0 0 1 1 1 0 Filaments in between nuclei protein-1 DUF2201_N PF13203.6 ELR23696.1 - 1.9 8.0 7.3 0.13 11.8 2.3 1.6 2 0 0 2 2 2 0 Putative metallopeptidase domain TUG-UBL1 PF11470.8 ELR23697.1 - 1.6e-17 63.5 0.0 3.5e-17 62.4 0.0 1.6 1 0 0 1 1 1 1 TUG ubiquitin-like domain UBX PF00789.20 ELR23697.1 - 3.5e-09 36.7 0.1 1.1e-05 25.5 0.1 2.6 2 0 0 2 2 2 2 UBX domain RBD PF02196.15 ELR23697.1 - 0.097 12.8 0.0 0.22 11.6 0.0 1.6 1 0 0 1 1 1 0 Raf-like Ras-binding domain Borrelia_P83 PF05262.11 ELR23697.1 - 0.39 9.2 12.4 0.59 8.6 12.4 1.3 1 0 0 1 1 1 0 Borrelia P83/100 protein DUF3395 PF11875.8 ELR23698.1 - 1.3e-42 145.4 0.5 2.2e-42 144.6 0.5 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3395) DnaJ PF00226.31 ELR23698.1 - 6.4e-22 77.4 0.7 1.1e-21 76.6 0.1 1.8 2 0 0 2 2 2 1 DnaJ domain 5_3_exonuc PF01367.20 ELR23698.1 - 0.22 12.2 2.6 0.36 11.4 0.1 2.3 2 0 0 2 2 2 0 5'-3' exonuclease, C-terminal SAM fold Com_YlbF PF06133.11 ELR23698.1 - 1.7 9.3 6.6 0.38 11.4 0.2 2.4 3 0 0 3 3 3 0 Control of competence regulator ComK, YlbF/YmcA p450 PF00067.22 ELR23699.1 - 8e-53 179.8 0.0 9.9e-53 179.5 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 MFS_1 PF07690.16 ELR23700.1 - 4.6e-40 137.6 36.4 8.9e-33 113.7 10.0 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily OATP PF03137.20 ELR23700.1 - 4e-06 25.4 0.0 4e-06 25.4 0.0 2.1 3 1 0 3 3 3 1 Organic Anion Transporter Polypeptide (OATP) family MFS_1_like PF12832.7 ELR23700.1 - 0.00032 19.7 11.5 0.0011 17.9 8.2 3.0 1 1 1 2 2 2 1 MFS_1 like family DUF4539 PF15072.6 ELR23701.1 - 1.7e-30 104.9 0.3 2.6e-30 104.3 0.3 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4539) ABC_membrane_2 PF06472.15 ELR23702.1 - 3.4e-93 311.9 0.6 5.1e-93 311.4 0.6 1.3 1 0 0 1 1 1 1 ABC transporter transmembrane region 2 ABC_tran PF00005.27 ELR23702.1 - 1.4e-16 61.2 0.0 3.3e-16 60.0 0.0 1.7 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 ELR23702.1 - 0.00098 18.6 0.0 0.37 10.2 0.0 2.5 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 ELR23702.1 - 0.011 15.6 0.0 0.022 14.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 ELR23702.1 - 0.029 14.9 0.0 0.057 13.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.6 ELR23702.1 - 0.041 13.6 0.0 0.1 12.4 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain SbcCD_C PF13558.6 ELR23702.1 - 0.046 13.9 0.0 0.13 12.5 0.0 1.8 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit AAA_18 PF13238.6 ELR23702.1 - 0.071 13.7 0.0 0.15 12.6 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 ELR23702.1 - 0.072 13.5 0.0 0.2 12.0 0.0 1.8 1 0 0 1 1 1 0 AAA ATPase domain SH3_9 PF14604.6 ELR23703.1 - 9.1e-18 63.9 0.2 1.6e-07 31.0 0.0 2.5 2 1 0 2 2 2 2 Variant SH3 domain SH3_1 PF00018.28 ELR23703.1 - 2e-15 56.1 0.0 2.5e-08 33.4 0.0 2.3 2 0 0 2 2 2 2 SH3 domain SH3_2 PF07653.17 ELR23703.1 - 1.7e-12 46.8 0.0 5.5e-07 29.2 0.0 2.4 2 0 0 2 2 2 2 Variant SH3 domain YihI PF04220.12 ELR23703.1 - 0.034 13.9 0.3 0.062 13.0 0.1 1.4 1 1 0 1 1 1 0 Der GTPase activator (YihI) TFIIA PF03153.13 ELR23703.1 - 5 7.0 10.0 6.2 6.7 10.0 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Nucleotid_trans PF03407.16 ELR23704.1 - 3.1e-05 24.0 0.0 4.3e-05 23.6 0.0 1.1 1 0 0 1 1 1 1 Nucleotide-diphospho-sugar transferase Glyco_transf_8 PF01501.20 ELR23704.1 - 0.0032 17.1 0.0 0.0047 16.5 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 8 Herpes_pp85 PF04637.12 ELR23704.1 - 1.4 7.3 5.5 1.5 7.2 4.1 1.6 2 0 0 2 2 2 0 Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25) WD40 PF00400.32 ELR23705.1 - 6.6e-17 61.6 7.1 2.5e-05 25.0 0.3 6.1 7 0 0 7 7 7 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ELR23705.1 - 3.9e-07 30.3 0.0 0.0024 18.1 0.0 2.9 2 1 1 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain PQQ_3 PF13570.6 ELR23705.1 - 2.1e-05 24.9 0.3 0.04 14.4 0.0 3.7 3 0 0 3 3 3 1 PQQ-like domain Nbas_N PF15492.6 ELR23705.1 - 0.017 14.5 0.1 1.3 8.3 0.0 2.5 3 0 0 3 3 3 0 Neuroblastoma-amplified sequence, N terminal Nup160 PF11715.8 ELR23705.1 - 0.032 12.9 0.0 0.18 10.4 0.0 2.0 2 0 0 2 2 2 0 Nucleoporin Nup120/160 DUF1513 PF07433.11 ELR23705.1 - 0.063 12.4 0.0 0.2 10.7 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1513) WD40_alt PF14077.6 ELR23705.1 - 0.093 12.6 0.0 0.18 11.7 0.0 1.4 1 0 0 1 1 1 0 Alternative WD40 repeat motif PQQ PF01011.21 ELR23705.1 - 0.098 12.6 0.1 0.27 11.3 0.1 1.8 1 0 0 1 1 1 0 PQQ enzyme repeat DivIC PF04977.15 ELR23705.1 - 0.25 11.1 0.8 0.44 10.4 0.8 1.3 1 0 0 1 1 1 0 Septum formation initiator Adap_comp_sub PF00928.21 ELR23706.1 - 7.8e-64 215.6 0.0 9.4e-64 215.3 0.0 1.1 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 ELR23706.1 - 0.00077 19.4 0.1 0.0013 18.6 0.1 1.3 1 0 0 1 1 1 1 Clathrin adaptor complex small chain 2OG-FeII_Oxy_3 PF13640.6 ELR23707.1 - 4.1e-11 43.6 0.0 6.9e-11 42.9 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy PF03171.20 ELR23707.1 - 0.0042 17.5 0.0 0.0086 16.5 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily META PF03724.16 ELR23711.1 - 0.028 14.4 0.1 0.049 13.6 0.1 1.4 1 0 0 1 1 1 0 META domain zf-C2H2_10 PF16588.5 ELR23716.1 - 9.2e-05 22.1 3.5 0.00026 20.6 3.5 1.8 1 0 0 1 1 1 1 C2H2 zinc-finger zf-CCHC_2 PF13696.6 ELR23716.1 - 0.034 14.0 9.0 0.093 12.6 9.0 1.8 1 0 0 1 1 1 0 Zinc knuckle rve PF00665.26 ELR23717.1 - 1.2e-13 51.3 0.2 2e-13 50.6 0.2 1.4 1 0 0 1 1 1 1 Integrase core domain RVT_2 PF07727.14 ELR23718.1 - 4.8e-41 141.0 0.2 7.1e-41 140.4 0.2 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) ALIX_LYPXL_bnd PF13949.6 ELR23718.1 - 0.073 12.4 0.1 0.12 11.6 0.1 1.3 1 0 0 1 1 1 0 ALIX V-shaped domain binding to HIV Hep_59 PF07052.11 ELR23719.1 - 2 9.2 0.0 2 9.2 0.0 2.6 2 1 0 2 2 2 0 Hepatocellular carcinoma-associated antigen 59 Pkinase_Tyr PF07714.17 ELR23721.1 - 0.012 14.9 0.0 0.021 14.1 0.0 1.3 1 0 0 1 1 1 0 Protein tyrosine kinase Pkinase PF00069.25 ELR23721.1 - 0.014 14.8 0.0 0.029 13.8 0.0 1.5 2 0 0 2 2 2 0 Protein kinase domain CRCB PF02537.15 ELR23722.1 - 0.023 15.0 2.6 0.038 14.3 2.6 1.3 1 1 0 1 1 1 0 CrcB-like protein, Camphor Resistance (CrcB) CCB1 PF12046.8 ELR23722.1 - 1.1 8.6 4.2 2.2 7.6 4.2 1.4 1 0 0 1 1 1 0 Cofactor assembly of complex C subunit B Cupin_5 PF06172.11 ELR23723.1 - 1.2e-20 74.2 0.0 2.2e-20 73.3 0.0 1.4 1 1 0 1 1 1 1 Cupin superfamily (DUF985) VSG_B PF13206.6 ELR23723.1 - 0.18 11.0 0.5 0.24 10.6 0.5 1.1 1 0 0 1 1 1 0 Trypanosomal VSG domain EGF_2 PF07974.13 ELR23724.1 - 0.0038 17.6 14.2 0.01 16.2 14.2 1.8 1 0 0 1 1 1 1 EGF-like domain EGF PF00008.27 ELR23724.1 - 0.037 14.3 9.6 0.11 12.9 9.6 1.9 1 0 0 1 1 1 0 EGF-like domain Laminin_EGF PF00053.24 ELR23724.1 - 0.048 13.8 6.3 0.12 12.6 6.3 1.6 1 0 0 1 1 1 0 Laminin EGF domain ATG16 PF08614.11 ELR23726.1 - 0.00036 20.8 4.3 0.00042 20.6 4.3 1.1 1 0 0 1 1 1 1 Autophagy protein 16 (ATG16) Leu_zip PF15294.6 ELR23726.1 - 0.0019 17.8 4.2 0.0023 17.5 4.2 1.0 1 0 0 1 1 1 1 Leucine zipper FPP PF05911.11 ELR23726.1 - 0.0051 15.1 3.2 0.006 14.9 3.2 1.0 1 0 0 1 1 1 1 Filament-like plant protein, long coiled-coil Atg14 PF10186.9 ELR23726.1 - 0.0091 15.1 1.1 0.011 14.9 1.1 1.0 1 0 0 1 1 1 1 Vacuolar sorting 38 and autophagy-related subunit 14 DUF3584 PF12128.8 ELR23726.1 - 0.011 13.3 2.5 0.013 13.1 2.5 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Spc7 PF08317.11 ELR23726.1 - 0.012 14.5 1.7 0.014 14.3 1.7 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF4472 PF14739.6 ELR23726.1 - 0.013 16.2 1.6 0.02 15.6 1.6 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4472) APG6_N PF17675.1 ELR23726.1 - 0.02 15.4 2.1 0.027 15.0 2.1 1.2 1 0 0 1 1 1 0 Apg6 coiled-coil region UPF0242 PF06785.11 ELR23726.1 - 0.023 14.8 1.2 0.029 14.5 1.2 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus DUF4407 PF14362.6 ELR23726.1 - 0.025 14.0 3.4 0.031 13.7 3.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF5105 PF17118.5 ELR23726.1 - 0.029 14.2 1.8 0.038 13.8 1.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF5105) FlaC_arch PF05377.11 ELR23726.1 - 0.1 13.0 1.4 0.76 10.2 0.2 2.2 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) PI3K_P85_iSH2 PF16454.5 ELR23726.1 - 0.17 11.5 5.1 0.4 10.3 5.1 1.6 1 1 0 1 1 1 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain Uso1_p115_C PF04871.13 ELR23726.1 - 0.17 12.3 5.6 0.25 11.7 5.6 1.3 1 0 0 1 1 1 0 Uso1 / p115 like vesicle tethering protein, C terminal region MscS_porin PF12795.7 ELR23726.1 - 0.2 11.2 13.4 0.86 9.1 13.7 1.8 1 1 0 1 1 1 0 Mechanosensitive ion channel porin domain Strep_SA_rep PF06696.11 ELR23726.1 - 0.22 11.5 7.1 4.1 7.5 0.3 3.5 3 0 0 3 3 3 0 Streptococcal surface antigen repeat SKA1 PF07160.12 ELR23726.1 - 0.24 11.2 4.6 0.25 11.2 3.5 1.5 1 1 1 2 2 2 0 Spindle and kinetochore-associated protein 1 DUF1664 PF07889.12 ELR23726.1 - 0.25 11.4 3.0 0.29 11.2 1.6 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) DUF4164 PF13747.6 ELR23726.1 - 0.32 11.3 4.6 0.45 10.8 4.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4164) GAS PF13851.6 ELR23726.1 - 0.37 10.1 8.8 2 7.7 9.0 1.8 1 1 0 1 1 1 0 Growth-arrest specific micro-tubule binding DUF3450 PF11932.8 ELR23726.1 - 1.5 8.1 10.6 2.5 7.3 8.9 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) V-SNARE PF05008.15 ELR23726.1 - 1.7 9.1 7.3 0.35 11.3 2.9 1.9 1 1 1 2 2 2 0 Vesicle transport v-SNARE protein N-terminus YabA PF06156.13 ELR23726.1 - 1.9 9.2 4.3 1.3 9.7 1.1 1.9 1 1 1 2 2 2 0 Initiation control protein YabA Spc24 PF08286.11 ELR23726.1 - 2.8 8.3 6.1 13 6.1 6.1 2.1 1 1 0 1 1 1 0 Spc24 subunit of Ndc80 BRCT PF00533.26 ELR23727.1 - 2.3e-10 40.7 0.4 5.1e-10 39.6 0.0 1.8 2 0 0 2 2 2 1 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 ELR23727.1 - 9e-07 29.2 0.2 2.8e-06 27.6 0.0 1.9 2 0 0 2 2 2 1 BRCT domain, a BRCA1 C-terminus domain PTCB-BRCT PF12738.7 ELR23727.1 - 1.8e-05 24.6 0.0 4.2e-05 23.4 0.0 1.6 1 0 0 1 1 1 1 twin BRCT domain CSD2 PF17876.1 ELR23727.1 - 0.076 13.2 0.3 0.3 11.3 0.3 2.1 1 1 0 1 1 1 0 Cold shock domain TIG PF01833.24 ELR23728.1 - 3.9e-05 23.6 0.4 0.063 13.3 0.1 2.3 2 0 0 2 2 2 2 IPT/TIG domain OapA_N PF08525.11 ELR23728.1 - 0.07 13.1 1.2 0.13 12.3 1.2 1.4 1 0 0 1 1 1 0 Opacity-associated protein A N-terminal motif SPT2 PF08243.11 ELR23729.1 - 6.5e-18 65.3 28.0 9.8e-18 64.7 28.0 1.3 1 0 0 1 1 1 1 SPT2 chromatin protein Ribosomal_60s PF00428.19 ELR23729.1 - 0.082 13.5 1.4 0.082 13.5 1.4 2.4 2 1 0 2 2 2 0 60s Acidic ribosomal protein BUD22 PF09073.10 ELR23729.1 - 0.75 9.1 22.8 0.85 8.9 22.8 1.0 1 0 0 1 1 1 0 BUD22 WDCP PF15390.6 ELR23729.1 - 1.3 7.3 7.0 1.5 7.2 7.0 1.0 1 0 0 1 1 1 0 WD repeat and coiled-coil-containing protein family Fzo_mitofusin PF04799.13 ELR23731.1 - 1.7 8.2 6.2 1.4 8.5 0.9 2.5 2 0 0 2 2 2 0 fzo-like conserved region Amino_oxidase PF01593.24 ELR23732.1 - 2e-79 268.0 5.6 6.7e-65 220.1 0.9 2.4 1 1 1 2 2 2 2 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 ELR23732.1 - 3.4e-11 43.2 0.7 1.3e-10 41.3 0.7 2.1 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 ELR23732.1 - 8.3e-09 35.1 0.3 7.1e-08 32.0 0.2 2.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 ELR23732.1 - 1.1e-08 35.1 1.6 3.1e-07 30.3 0.0 3.0 3 0 0 3 3 3 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 ELR23732.1 - 4.9e-07 29.2 1.5 1.3e-06 27.8 1.5 1.8 1 0 0 1 1 1 1 FAD binding domain FAD_oxidored PF12831.7 ELR23732.1 - 1.5e-06 27.8 0.1 1.3e-05 24.7 0.1 2.6 2 0 0 2 2 2 1 FAD dependent oxidoreductase HI0933_like PF03486.14 ELR23732.1 - 2.9e-06 26.2 0.2 1.9e-05 23.5 0.6 2.1 2 0 0 2 2 2 1 HI0933-like protein Pyr_redox PF00070.27 ELR23732.1 - 5.2e-06 26.9 0.9 0.00044 20.7 0.3 2.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 ELR23732.1 - 8.9e-06 25.2 0.2 0.00079 18.8 0.6 2.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase AlaDh_PNT_C PF01262.21 ELR23732.1 - 5.4e-05 22.6 0.1 0.00013 21.4 0.1 1.6 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain GIDA PF01134.22 ELR23732.1 - 8.7e-05 21.8 1.0 0.00015 21.0 1.0 1.3 1 0 0 1 1 1 1 Glucose inhibited division protein A Thi4 PF01946.17 ELR23732.1 - 0.006 15.9 0.2 0.011 15.0 0.2 1.3 1 0 0 1 1 1 1 Thi4 family XdhC_C PF13478.6 ELR23732.1 - 0.042 14.4 0.3 0.23 12.0 0.3 2.4 1 0 0 1 1 1 0 XdhC Rossmann domain Lycopene_cycl PF05834.12 ELR23732.1 - 0.052 12.6 0.2 0.052 12.6 0.2 1.7 2 0 0 2 2 2 0 Lycopene cyclase protein MCRA PF06100.11 ELR23732.1 - 0.092 11.5 0.1 0.16 10.7 0.1 1.3 1 0 0 1 1 1 0 MCRA family eIF-3c_N PF05470.12 ELR23733.1 - 4.3 5.5 6.5 2.7 6.2 4.2 1.6 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit 8 N-terminus HALZ PF02183.18 ELR23734.1 - 0.031 14.5 0.9 0.089 13.0 0.9 1.8 1 0 0 1 1 1 0 Homeobox associated leucine zipper YabA PF06156.13 ELR23734.1 - 0.31 11.7 0.1 0.31 11.7 0.1 2.6 3 0 0 3 3 3 0 Initiation control protein YabA RhoGAP PF00620.27 ELR23736.1 - 3.6e-32 111.3 0.6 8.3e-32 110.1 0.6 1.6 1 0 0 1 1 1 1 RhoGAP domain SH3_1 PF00018.28 ELR23736.1 - 0.0017 17.9 0.1 0.0042 16.7 0.1 1.6 1 0 0 1 1 1 1 SH3 domain Dor1 PF04124.12 ELR23737.1 - 4.1e-83 278.9 1.1 2.1e-70 237.1 0.0 2.0 1 1 1 2 2 2 2 Dor1-like family Vps51 PF08700.11 ELR23737.1 - 2.5e-09 37.1 0.6 7e-09 35.7 0.6 1.9 1 0 0 1 1 1 1 Vps51/Vps67 Exo84_C PF16528.5 ELR23737.1 - 0.0004 20.3 0.2 0.069 13.0 0.0 3.2 2 1 0 2 2 2 1 Exocyst component 84 C-terminal COG2 PF06148.11 ELR23737.1 - 0.016 15.3 0.4 0.037 14.1 0.3 1.7 1 1 0 1 1 1 0 COG (conserved oligomeric Golgi) complex component, COG2 FNIP_C PF14638.6 ELR23737.1 - 0.032 13.9 0.7 0.068 12.8 0.7 1.6 1 1 0 1 1 1 0 Folliculin-interacting protein C-terminus NACHT_N PF17100.5 ELR23737.1 - 0.11 12.4 0.7 0.19 11.6 0.7 1.3 1 0 0 1 1 1 0 N-terminal domain of NWD NACHT-NTPase IKKbetaNEMObind PF12179.8 ELR23737.1 - 0.36 10.9 2.9 0.7 10.0 0.8 2.6 2 0 0 2 2 2 0 I-kappa-kinase-beta NEMO binding domain Drf_GBD PF06371.13 ELR23738.1 - 0.00044 19.9 0.1 0.00044 19.9 0.1 4.0 4 1 0 4 4 4 1 Diaphanous GTPase-binding Domain Ribosomal_60s PF00428.19 ELR23738.1 - 0.54 10.9 20.8 0.62 10.7 6.6 4.0 3 0 0 3 3 3 0 60s Acidic ribosomal protein ETRAMP PF09716.10 ELR23738.1 - 1.3 9.1 6.2 6 7.0 1.1 3.4 3 0 0 3 3 3 0 Malarial early transcribed membrane protein (ETRAMP) HATPase_c PF02518.26 ELR23740.1 - 1.3e-31 109.4 0.0 2.6e-31 108.4 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 ELR23740.1 - 4.1e-23 81.7 0.1 7.2e-23 80.9 0.1 1.4 1 0 0 1 1 1 1 Response regulator receiver domain HisKA PF00512.25 ELR23740.1 - 1.5e-12 47.3 0.0 3.2e-12 46.3 0.0 1.6 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain NCD3G PF07562.14 ELR23741.1 - 0.00082 19.3 8.4 0.081 12.9 1.9 2.3 2 0 0 2 2 2 2 Nine Cysteines Domain of family 3 GPCR zinc-ribbon_6 PF10005.9 ELR23741.1 - 0.0023 18.6 4.1 0.35 11.6 0.3 2.4 2 0 0 2 2 2 2 zinc-ribbon domain Cytochrom_c3_2 PF14537.6 ELR23741.1 - 0.85 10.1 10.3 3.1 8.3 10.3 2.0 1 1 0 1 1 1 0 Cytochrome c3 zf-RanBP PF00641.18 ELR23741.1 - 0.97 8.8 18.0 0.81 9.1 5.0 3.5 3 1 0 3 3 3 0 Zn-finger in Ran binding protein and others zinc_ribbon_15 PF17032.5 ELR23741.1 - 1.2 9.9 6.9 15 6.4 1.2 2.3 2 0 0 2 2 2 0 zinc-ribbon family DUF2688 PF10892.8 ELR23741.1 - 1.3 8.6 8.2 1.5 8.4 1.5 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2688) DZR PF12773.7 ELR23741.1 - 3.2 7.8 13.2 9.5 6.3 13.3 1.8 1 1 0 1 1 1 0 Double zinc ribbon Zn_ribbon_SprT PF17283.2 ELR23741.1 - 6.9 6.7 20.7 1.4 8.9 5.2 2.9 2 1 0 2 2 2 0 SprT-like zinc ribbon domain FYVE PF01363.21 ELR23741.1 - 7.3 6.8 17.1 14 5.9 10.2 2.4 1 1 1 2 2 2 0 FYVE zinc finger DHHC PF01529.20 ELR23741.1 - 9.7 6.3 9.8 3 7.9 3.3 2.1 2 0 0 2 2 2 0 DHHC palmitoyltransferase zf-C3HC4_3 PF13920.6 ELR23742.1 - 7e-07 29.0 17.9 7e-07 29.0 17.9 2.9 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 ELR23742.1 - 2.2e-05 24.2 22.8 2.2e-05 24.2 22.8 2.4 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ELR23742.1 - 3.6e-05 23.6 21.9 3.6e-05 23.6 21.9 3.1 2 1 0 2 2 2 1 zinc-RING finger domain zf-RING_2 PF13639.6 ELR23742.1 - 0.0001 22.6 22.6 0.0001 22.6 22.6 2.9 2 1 0 2 2 2 1 Ring finger domain zf-C3HC4 PF00097.25 ELR23742.1 - 0.00064 19.5 23.9 0.00064 19.5 23.9 2.8 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-B_box PF00643.24 ELR23742.1 - 0.0074 16.4 5.5 0.0074 16.4 5.5 3.6 3 1 0 3 3 3 1 B-box zinc finger U-box PF04564.15 ELR23742.1 - 0.033 14.4 0.0 0.064 13.4 0.0 1.5 1 0 0 1 1 1 0 U-box domain Filament PF00038.21 ELR23742.1 - 1.6 8.3 7.4 1.4 8.4 4.1 2.0 1 1 1 2 2 2 0 Intermediate filament protein FoP_duplication PF13865.6 ELR23743.1 - 6e-17 62.0 5.7 6e-17 62.0 5.7 3.9 3 1 2 5 5 5 1 C-terminal duplication domain of Friend of PRMT1 RIO1 PF01163.22 ELR23744.1 - 8.3e-51 172.3 0.2 1.9e-50 171.1 0.2 1.6 1 0 0 1 1 1 1 RIO1 family Rio2_N PF09202.11 ELR23744.1 - 1.5e-33 114.9 1.1 2.8e-33 114.0 0.7 1.7 2 0 0 2 2 2 1 Rio2, N-terminal APH PF01636.23 ELR23744.1 - 1e-10 42.0 0.0 2e-05 24.6 0.0 3.1 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.14 ELR23744.1 - 1.7e-07 30.8 0.1 0.0088 15.4 0.0 2.5 2 0 0 2 2 2 2 Lipopolysaccharide kinase (Kdo/WaaP) family HTH_45 PF14947.6 ELR23744.1 - 0.033 14.2 2.8 0.082 12.9 0.3 2.7 3 0 0 3 3 3 0 Winged helix-turn-helix PadR PF03551.14 ELR23744.1 - 0.094 12.7 1.9 8.1 6.5 0.2 3.1 2 1 1 3 3 3 0 Transcriptional regulator PadR-like family DUF373 PF04123.13 ELR23745.1 - 0.0076 15.7 3.5 0.0099 15.4 3.5 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF373) Tetraspanin PF00335.20 ELR23745.1 - 0.027 14.2 17.0 0.11 12.2 17.0 1.8 1 1 0 1 1 1 0 Tetraspanin family PIP49_N PF14875.6 ELR23745.1 - 0.062 13.2 0.8 0.062 13.2 0.8 1.4 1 1 0 1 1 1 0 N-term cysteine-rich ER, FAM69 DUF2644 PF10841.8 ELR23745.1 - 1.2 9.4 5.4 2.1 8.6 0.4 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2644) SCIMP PF15050.6 ELR23745.1 - 6.2 7.3 5.9 15 6.0 0.5 2.4 2 0 0 2 2 2 0 SCIMP protein LapA_dom PF06305.11 ELR23747.1 - 0.00013 21.7 0.1 0.00013 21.7 0.1 2.0 2 0 0 2 2 2 1 Lipopolysaccharide assembly protein A domain DUF4781 PF16013.5 ELR23747.1 - 0.041 12.7 0.3 0.1 11.4 0.3 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4781) DUF2681 PF10883.8 ELR23747.1 - 0.15 12.5 0.1 0.27 11.7 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2681) Dam PF05869.11 ELR23749.1 - 0.0016 18.0 0.2 0.0028 17.2 0.2 1.4 1 0 0 1 1 1 1 DNA N-6-adenine-methyltransferase (Dam) RVT_1 PF00078.27 ELR23750.1 - 8.7e-08 31.9 0.1 2.2e-07 30.6 0.0 1.6 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) EGF_2 PF07974.13 ELR23752.1 - 1e-28 99.4 142.9 2.3e-06 27.8 7.6 9.9 10 0 0 10 10 10 8 EGF-like domain EGF PF00008.27 ELR23752.1 - 2.5e-14 53.3 103.0 6.5e-07 29.5 3.2 9.4 9 0 0 9 9 9 6 EGF-like domain hEGF PF12661.7 ELR23752.1 - 4.5e-12 46.1 103.5 0.00065 20.2 3.1 10.0 9 0 0 9 9 9 8 Human growth factor-like EGF EGF_alliinase PF04863.13 ELR23752.1 - 0.016 15.6 8.0 0.016 15.6 8.0 10.1 6 3 4 10 10 10 0 Alliinase EGF-like domain DUF3318 PF11780.8 ELR23752.1 - 0.27 11.2 0.6 2.6 8.0 0.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3318) BRO1 PF03097.18 ELR23753.1 - 2.3e-25 89.3 0.0 2.9e-25 88.9 0.0 1.2 1 0 0 1 1 1 1 BRO1-like domain RFX_DNA_binding PF02257.15 ELR23754.1 - 4.2e-16 59.3 0.2 4.2e-16 59.3 0.2 2.0 3 0 0 3 3 3 1 RFX DNA-binding domain Pox_D5 PF03288.16 ELR23754.1 - 0.09 13.3 0.4 0.55 10.8 0.0 2.2 2 0 0 2 2 2 0 Poxvirus D5 protein-like Rrn6 PF10214.9 ELR23754.1 - 0.18 10.3 8.7 0.25 9.8 8.7 1.1 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor Pex14_N PF04695.13 ELR23754.1 - 6.1 7.5 13.9 2 9.0 5.5 2.3 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region RCC1 PF00415.18 ELR23755.1 - 1.7e-24 86.2 0.2 2.9e-10 40.6 0.0 5.1 4 1 1 5 5 5 4 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 ELR23755.1 - 5.5e-09 35.6 2.9 0.0045 16.7 0.0 4.2 4 1 0 4 4 4 2 Regulator of chromosome condensation (RCC1) repeat Pkinase_Tyr PF07714.17 ELR23756.1 - 2.4e-49 168.0 0.0 3.2e-49 167.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ELR23756.1 - 2.9e-41 141.6 0.0 4.2e-41 141.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain ANAPC4_WD40 PF12894.7 ELR23756.1 - 0.014 15.7 0.7 5.3 7.4 0.0 3.8 3 2 0 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 ELR23756.1 - 0.02 15.8 12.2 6.3 7.8 0.0 6.5 6 1 0 6 6 6 0 WD domain, G-beta repeat Tfb2_C PF18307.1 ELR23756.1 - 0.22 12.0 1.2 1.2 9.6 0.1 2.8 3 0 0 3 3 3 0 Transcription factor Tfb2 (p52) C-terminal domain Syja_N PF02383.18 ELR23757.1 - 2.8e-99 332.4 0.1 3.6e-99 332.1 0.1 1.1 1 0 0 1 1 1 1 SacI homology domain DUF872 PF05915.12 ELR23757.1 - 0.0027 17.8 1.2 0.021 15.0 0.4 2.3 2 0 0 2 2 2 1 Eukaryotic protein of unknown function (DUF872) TMEM192 PF14802.6 ELR23757.1 - 0.034 13.2 0.9 0.059 12.5 0.9 1.2 1 0 0 1 1 1 0 TMEM192 family Endonuclease_5 PF04493.14 ELR23758.1 - 5.9e-12 45.7 0.0 8.2e-12 45.2 0.0 1.2 1 0 0 1 1 1 1 Endonuclease V SET PF00856.28 ELR23759.1 - 5e-05 23.7 0.0 0.00026 21.4 0.0 2.1 2 1 0 2 2 2 1 SET domain Rubis-subs-bind PF09273.11 ELR23759.1 - 6.6e-05 23.6 0.0 0.00011 22.8 0.0 1.3 1 0 0 1 1 1 1 Rubisco LSMT substrate-binding Aquarius_N PF16399.5 ELR23760.1 - 4.2e-194 646.9 0.0 5.5e-194 646.5 0.0 1.0 1 0 0 1 1 1 1 Intron-binding protein aquarius N-terminus FHA PF00498.26 ELR23760.1 - 1.6e-07 31.5 0.0 3e-07 30.7 0.0 1.5 1 0 0 1 1 1 1 FHA domain MCRS_N PF13325.6 ELR23760.1 - 5.9e-05 23.2 0.0 0.00025 21.1 0.0 2.1 1 0 0 1 1 1 1 N-terminal region of micro-spherule protein FoP_duplication PF13865.6 ELR23761.1 - 1.3 9.6 8.3 1.5 9.4 8.3 1.1 1 0 0 1 1 1 0 C-terminal duplication domain of Friend of PRMT1 RhoGEF PF00621.20 ELR23762.1 - 6.7e-43 147.0 2.1 1.1e-42 146.4 2.1 1.3 1 0 0 1 1 1 1 RhoGEF domain PH_13 PF16652.5 ELR23762.1 - 0.074 12.9 2.9 0.21 11.4 0.7 2.4 2 1 0 2 2 2 0 Pleckstrin homology domain GFO_IDH_MocA PF01408.22 ELR23764.1 - 3.1e-16 60.3 0.0 5.4e-16 59.5 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold NAD_binding_3 PF03447.16 ELR23764.1 - 0.034 14.8 0.1 0.075 13.7 0.1 1.6 1 0 0 1 1 1 0 Homoserine dehydrogenase, NAD binding domain DeoC PF01791.9 ELR23765.1 - 1.4e-30 106.7 0.1 1.7e-30 106.4 0.1 1.1 1 0 0 1 1 1 1 DeoC/LacD family aldolase CHAT PF12770.7 ELR23765.1 - 0.13 11.7 0.1 0.45 9.9 0.1 1.8 2 0 0 2 2 2 0 CHAT domain DUF1207 PF06727.11 ELR23765.1 - 0.21 10.5 0.0 0.31 9.9 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1207) Oxidored_molyb PF00174.19 ELR23766.1 - 5.7e-55 185.6 0.0 1e-54 184.7 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase molybdopterin binding domain Mo-co_dimer PF03404.16 ELR23766.1 - 3.4e-09 36.8 0.2 8.8e-09 35.5 0.2 1.7 1 0 0 1 1 1 1 Mo-co oxidoreductase dimerisation domain HD PF01966.22 ELR23767.1 - 1.4e-06 28.5 0.1 2.4e-06 27.8 0.1 1.4 1 0 0 1 1 1 1 HD domain HD_4 PF13328.6 ELR23767.1 - 3.4e-05 23.6 0.7 9.8e-05 22.1 0.5 1.8 1 1 0 1 1 1 1 HD domain MIOX PF05153.15 ELR23767.1 - 0.089 12.3 0.2 0.35 10.4 0.2 1.8 1 1 0 1 1 1 0 Myo-inositol oxygenase DUF3565 PF12088.8 ELR23767.1 - 0.76 9.8 2.8 1.3 9.0 0.0 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF3565) PWWP PF00855.17 ELR23768.1 - 3.2e-18 65.9 0.7 3.2e-18 65.9 0.7 2.8 3 0 0 3 3 3 1 PWWP domain Med26 PF08711.11 ELR23768.1 - 8.2e-05 22.6 0.2 0.00018 21.4 0.2 1.6 1 0 0 1 1 1 1 TFIIS helical bundle-like domain PBP_sp32 PF07222.12 ELR23769.1 - 1.1 8.6 8.9 1.4 8.3 8.9 1.1 1 0 0 1 1 1 0 Proacrosin binding protein sp32 Pox_Ag35 PF03286.14 ELR23769.1 - 1.8 8.3 6.0 2 8.2 6.0 1.1 1 0 0 1 1 1 0 Pox virus Ag35 surface protein DUF389 PF04087.14 ELR23770.1 - 1e-25 90.5 2.4 1.2e-25 90.2 2.4 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF389) 7TM_GPCR_Sra PF02117.16 ELR23770.1 - 0.051 12.4 0.0 0.082 11.7 0.0 1.2 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Sra Mo-co_dimer PF03404.16 ELR23771.1 - 1.3e-09 38.2 0.8 2.1e-09 37.5 0.8 1.4 1 1 0 1 1 1 1 Mo-co oxidoreductase dimerisation domain CAP PF00188.26 ELR23772.1 - 0.024 15.5 0.9 0.31 11.9 0.9 2.3 1 1 0 1 1 1 0 Cysteine-rich secretory protein family AAA_12 PF13087.6 ELR23773.1 - 1.6e-22 80.1 0.0 1.9e-22 79.9 0.0 1.1 1 0 0 1 1 1 1 AAA domain UvrD_C_2 PF13538.6 ELR23773.1 - 0.004 17.0 0.1 0.0086 15.9 0.1 1.6 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain Melibiase_2 PF16499.5 ELR23774.1 - 5e-19 68.6 0.0 5.7e-19 68.4 0.0 1.0 1 0 0 1 1 1 1 Alpha galactosidase A RabGAP-TBC PF00566.18 ELR23776.1 - 7.2e-56 189.2 0.1 1.3e-55 188.4 0.1 1.3 1 0 0 1 1 1 1 Rab-GTPase-TBC domain Macoilin PF09726.9 ELR23776.1 - 0.089 11.3 4.9 0.13 10.8 4.9 1.2 1 0 0 1 1 1 0 Macoilin family Phytochelatin PF05023.14 ELR23777.1 - 1.7e-31 109.2 0.0 4e-23 81.8 0.0 2.0 2 0 0 2 2 2 2 Phytochelatin synthase Ig_5 PF16681.5 ELR23777.1 - 0.14 12.6 0.0 0.26 11.7 0.0 1.4 1 0 0 1 1 1 0 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Fucokinase PF07959.12 ELR23778.1 - 1.8e-106 356.5 0.0 2.2e-106 356.2 0.0 1.1 1 0 0 1 1 1 1 L-fucokinase TIG PF01833.24 ELR23779.1 - 0.011 15.7 0.4 0.88 9.7 0.3 2.3 2 1 0 2 2 2 0 IPT/TIG domain Homeobox_KN PF05920.11 ELR23783.1 - 3.4e-19 68.5 1.0 7.5e-19 67.4 1.0 1.6 1 0 0 1 1 1 1 Homeobox KN domain Homeodomain PF00046.29 ELR23783.1 - 9e-12 44.7 1.4 1.3e-11 44.1 1.4 1.3 1 0 0 1 1 1 1 Homeodomain SidC_N PF18219.1 ELR23783.1 - 0.015 14.3 0.2 0.019 14.0 0.2 1.2 1 0 0 1 1 1 0 SidC N-terminal domain HTH_3 PF01381.22 ELR23783.1 - 0.028 14.5 0.7 0.2 11.8 0.0 2.0 2 0 0 2 2 2 0 Helix-turn-helix CH PF00307.31 ELR23783.1 - 0.048 13.8 0.1 0.089 13.0 0.0 1.5 1 1 0 1 1 1 0 Calponin homology (CH) domain TC1 PF15063.6 ELR23783.1 - 0.051 13.4 0.0 0.088 12.7 0.0 1.3 1 0 0 1 1 1 0 Thyroid cancer protein 1 Pkinase_Tyr PF07714.17 ELR23786.1 - 5.1e-18 65.3 0.0 7.3e-18 64.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ELR23786.1 - 4e-14 52.6 0.0 5.1e-14 52.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Ank_2 PF12796.7 ELR23787.1 - 1.5e-34 118.4 0.0 9.3e-12 45.4 0.0 4.3 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ELR23787.1 - 1.3e-29 102.2 0.0 1.7e-08 34.9 0.0 5.6 3 1 1 5 5 5 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 ELR23787.1 - 2e-26 89.1 0.0 0.0013 19.0 0.0 6.9 7 0 0 7 7 7 6 Ankyrin repeat Ank PF00023.30 ELR23787.1 - 2.3e-24 84.7 0.3 0.0028 18.0 0.1 8.0 8 0 0 8 8 8 4 Ankyrin repeat Ank_5 PF13857.6 ELR23787.1 - 2.9e-24 84.8 1.8 2.7e-09 37.1 0.0 7.1 4 2 3 7 7 7 5 Ankyrin repeats (many copies) adh_short PF00106.25 ELR23787.1 - 0.07 12.6 0.1 12 5.3 0.0 2.7 3 0 0 3 3 3 0 short chain dehydrogenase Glyoxalase_6 PF18029.1 ELR23787.1 - 0.23 12.3 10.7 4.8 8.0 0.1 4.6 1 1 1 3 3 3 0 Glyoxalase-like domain NOA36 PF06524.12 ELR23787.1 - 5.4 6.2 7.8 7.6 5.8 7.8 1.1 1 0 0 1 1 1 0 NOA36 protein CENP-B_dimeris PF09026.10 ELR23787.1 - 8.4 6.8 12.9 14 6.2 12.9 1.3 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Podoplanin PF05808.11 ELR23788.1 - 9 6.4 7.9 5.3 7.1 2.2 2.5 1 1 1 2 2 2 0 Podoplanin Glucokinase PF02685.16 ELR23790.1 - 3.3e-11 42.8 0.0 3.8e-11 42.6 0.0 1.0 1 0 0 1 1 1 1 Glucokinase DUF3750 PF12570.8 ELR23790.1 - 0.068 13.9 0.0 0.11 13.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3750) AIG1 PF04548.16 ELR23793.1 - 1.7e-08 34.1 0.3 3.4e-07 29.8 0.0 2.2 2 0 0 2 2 2 1 AIG1 family MMR_HSR1 PF01926.23 ELR23793.1 - 2.1e-05 24.6 0.1 9.3e-05 22.5 0.0 2.1 2 2 0 2 2 2 1 50S ribosome-binding GTPase AAA_22 PF13401.6 ELR23793.1 - 0.00039 20.7 0.0 0.0019 18.5 0.0 2.1 2 1 0 2 2 1 1 AAA domain Phage_GP20 PF06810.11 ELR23793.1 - 0.0015 18.4 2.8 0.0023 17.8 2.8 1.2 1 0 0 1 1 1 1 Phage minor structural protein GP20 YscO PF07321.12 ELR23793.1 - 0.0048 16.9 10.6 0.0072 16.3 10.6 1.2 1 0 0 1 1 1 1 Type III secretion protein YscO ADIP PF11559.8 ELR23793.1 - 0.0059 16.7 6.2 0.0088 16.1 6.2 1.2 1 0 0 1 1 1 1 Afadin- and alpha -actinin-Binding AAA_16 PF13191.6 ELR23793.1 - 0.0071 16.7 0.4 0.061 13.7 0.0 2.2 2 0 0 2 2 2 1 AAA ATPase domain Exonuc_VII_L PF02601.15 ELR23793.1 - 0.017 14.7 1.3 0.023 14.3 1.3 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit MscS_porin PF12795.7 ELR23793.1 - 0.024 14.2 2.6 0.039 13.5 2.6 1.2 1 0 0 1 1 1 0 Mechanosensitive ion channel porin domain ABC_tran PF00005.27 ELR23793.1 - 0.052 14.1 0.3 0.82 10.2 0.0 2.2 2 0 0 2 2 2 0 ABC transporter EzrA PF06160.12 ELR23793.1 - 0.063 11.4 4.8 0.084 11.0 4.8 1.1 1 0 0 1 1 1 0 Septation ring formation regulator, EzrA Roc PF08477.13 ELR23793.1 - 0.066 13.4 0.0 0.22 11.7 0.0 1.9 2 0 0 2 2 1 0 Ras of Complex, Roc, domain of DAPkinase kleA_kleC PF17383.2 ELR23793.1 - 0.077 13.3 6.8 0.044 14.1 4.0 2.1 2 1 1 3 3 2 0 Uncharacterized KorC regulated protein A TMEM65 PF10507.9 ELR23793.1 - 0.098 12.6 0.0 0.24 11.4 0.0 1.6 1 0 0 1 1 1 0 Transmembrane protein 65 TPR_MLP1_2 PF07926.12 ELR23793.1 - 0.098 12.7 6.9 0.16 12.0 6.9 1.3 1 0 0 1 1 1 0 TPR/MLP1/MLP2-like protein OmpH PF03938.14 ELR23793.1 - 0.12 12.7 5.4 0.18 12.1 5.4 1.3 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) Ras PF00071.22 ELR23793.1 - 0.12 11.9 0.1 0.35 10.4 0.0 1.8 2 0 0 2 2 2 0 Ras family Spc7 PF08317.11 ELR23793.1 - 0.12 11.2 7.6 0.17 10.7 7.6 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein Kre28 PF17097.5 ELR23793.1 - 0.13 11.2 1.9 0.18 10.7 1.9 1.1 1 0 0 1 1 1 0 Spindle pole body component DUF4472 PF14739.6 ELR23793.1 - 0.2 12.4 4.0 0.33 11.7 4.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4472) TolA_bind_tri PF16331.5 ELR23793.1 - 0.27 11.4 9.8 5.8 7.1 9.3 2.2 1 1 0 1 1 1 0 TolA binding protein trimerisation YabA PF06156.13 ELR23793.1 - 0.28 11.9 2.4 0.62 10.7 2.4 1.6 1 1 0 1 1 1 0 Initiation control protein YabA Laminin_II PF06009.12 ELR23793.1 - 0.31 11.0 5.4 4.8 7.2 0.2 2.5 2 1 1 3 3 3 0 Laminin Domain II Fmp27_WPPW PF10359.9 ELR23793.1 - 0.43 9.4 4.7 0.6 8.9 4.7 1.1 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain Atg14 PF10186.9 ELR23793.1 - 0.87 8.6 5.9 1.3 8.0 5.9 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 SlyX PF04102.12 ELR23793.1 - 1.1 10.0 5.3 2.2 9.0 5.3 1.5 1 0 0 1 1 1 0 SlyX FliJ PF02050.16 ELR23793.1 - 1.2 9.4 13.3 3.5 7.9 12.6 1.9 1 1 0 1 1 1 0 Flagellar FliJ protein DUF724 PF05266.14 ELR23793.1 - 1.5 8.6 4.9 2.4 8.0 4.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF724) UPF0242 PF06785.11 ELR23793.1 - 2 8.5 5.2 3 7.9 5.2 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus AIG1 PF04548.16 ELR23794.1 - 3.4e-06 26.5 0.0 8.5e-06 25.2 0.0 1.6 2 0 0 2 2 2 1 AIG1 family Helicase_RecD PF05127.14 ELR23794.1 - 0.039 13.8 0.0 0.039 13.8 0.0 2.1 2 1 0 2 2 2 0 Helicase APG6_N PF17675.1 ELR23794.1 - 0.048 14.2 19.2 0.083 13.4 19.2 1.4 1 0 0 1 1 1 0 Apg6 coiled-coil region ERM PF00769.19 ELR23794.1 - 0.055 13.3 27.0 0.08 12.7 27.0 1.2 1 0 0 1 1 1 0 Ezrin/radixin/moesin family DUF874 PF05917.11 ELR23794.1 - 2.7 6.9 8.9 3.7 6.5 8.9 1.1 1 0 0 1 1 1 0 Helicobacter pylori protein of unknown function (DUF874) Band_7_C PF16200.5 ELR23795.1 - 0.011 15.8 0.0 0.019 15.0 0.0 1.4 1 0 0 1 1 1 0 C-terminal region of band_7 zf-His_Me_endon PF05551.11 ELR23797.1 - 0.00079 19.6 1.4 0.00079 19.6 1.4 1.9 3 0 0 3 3 3 1 Zinc-binding loop region of homing endonuclease BTV_NS2 PF04514.12 ELR23798.1 - 0.31 9.8 0.6 0.48 9.2 0.6 1.1 1 0 0 1 1 1 0 Bluetongue virus non-structural protein NS2 Chlam_PMP PF02415.17 ELR23798.1 - 0.4 11.2 24.9 0.98 10.0 0.0 6.7 8 0 0 8 8 8 0 Chlamydia polymorphic membrane protein (Chlamydia_PMP) repeat SKG6 PF08693.10 ELR23799.1 - 0.005 16.2 11.8 0.017 14.5 11.8 1.9 1 0 0 1 1 1 1 Transmembrane alpha-helix domain Rax2 PF12768.7 ELR23799.1 - 0.023 14.1 1.3 0.23 10.9 0.0 2.2 2 0 0 2 2 2 0 Cortical protein marker for cell polarity DUF4448 PF14610.6 ELR23799.1 - 0.084 12.6 0.0 0.18 11.6 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4448) TMEM154 PF15102.6 ELR23799.1 - 0.096 12.6 0.0 0.24 11.3 0.0 1.7 1 0 0 1 1 1 0 TMEM154 protein family DUF1565 PF07602.11 ELR23800.1 - 0.016 14.5 0.0 0.033 13.5 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1565) DUF3081 PF11280.8 ELR23804.1 - 0.14 12.0 0.1 0.39 10.6 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3081) GBP PF02263.19 ELR23805.1 - 0.077 12.3 0.5 0.39 10.0 0.0 2.0 2 0 0 2 2 2 0 Guanylate-binding protein, N-terminal domain DUF1053 PF06327.14 ELR23805.1 - 0.1 13.2 1.7 0.15 12.7 1.7 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1053) Integrase_DNA PF02920.15 ELR23806.1 - 0.042 13.6 0.1 0.12 12.1 0.1 1.8 1 0 0 1 1 1 0 DNA binding domain of tn916 integrase XRCC4 PF06632.12 ELR23806.1 - 0.056 12.3 5.7 0.11 11.3 5.7 1.5 1 0 0 1 1 1 0 DNA double-strand break repair and V(D)J recombination protein XRCC4 Pkinase_Tyr PF07714.17 ELR23807.1 - 3e-78 262.7 0.0 8.1e-57 192.5 0.0 3.1 2 1 1 3 3 3 3 Protein tyrosine kinase Pkinase PF00069.25 ELR23807.1 - 2.3e-62 210.7 0.0 2.6e-49 168.0 0.0 3.1 3 0 0 3 3 3 2 Protein kinase domain Peripla_BP_6 PF13458.6 ELR23807.1 - 1.2e-41 143.5 0.8 6.2e-20 72.1 0.0 3.4 2 1 0 2 2 2 2 Periplasmic binding protein ANF_receptor PF01094.28 ELR23807.1 - 0.00082 18.6 0.0 0.38 9.8 0.0 2.2 2 0 0 2 2 2 2 Receptor family ligand binding region Kinase-like PF14531.6 ELR23807.1 - 0.0078 15.6 0.0 0.02 14.2 0.0 1.6 2 0 0 2 2 2 1 Kinase-like 14-3-3 PF00244.20 ELR23809.1 - 2.1e-47 161.5 0.0 2.9e-47 161.0 0.0 1.2 1 0 0 1 1 1 1 14-3-3 protein Caudo_TAP PF02413.17 ELR23809.1 - 0.75 9.9 7.3 0.37 10.9 4.2 2.1 2 0 0 2 2 2 0 Caudovirales tail fibre assembly protein, lambda gpK T6SS_HCP PF05638.12 ELR23811.1 - 1.7e-06 28.5 0.0 3.7e-06 27.4 0.0 1.6 1 0 0 1 1 1 1 Type VI secretion system effector, Hcp PEX11 PF05648.14 ELR23812.1 - 3.2e-36 124.9 1.9 9.8e-36 123.3 1.9 1.7 1 1 0 1 1 1 1 Peroxisomal biogenesis factor 11 (PEX11) HA PF03457.14 ELR23813.1 - 4.8e-58 193.4 26.1 3.1e-21 75.5 0.3 4.2 4 0 0 4 4 4 3 Helicase associated domain Bacteriocin_IIi PF11758.8 ELR23813.1 - 0.28 11.0 1.3 8.6 6.3 0.1 2.5 2 0 0 2 2 2 0 Aureocin-like type II bacteriocin UCH PF00443.29 ELR23814.1 - 2.9e-28 99.1 0.0 3.2e-28 98.9 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 ELR23814.1 - 8.6e-12 45.3 0.0 1.2e-11 44.8 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase RhoGAP PF00620.27 ELR23815.1 - 7.1e-41 139.6 0.0 1.3e-40 138.7 0.0 1.4 1 1 0 1 1 1 1 RhoGAP domain SH3_1 PF00018.28 ELR23815.1 - 4.2e-10 39.1 0.0 7.6e-10 38.3 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 ELR23815.1 - 5.5e-09 35.8 0.0 1.4e-08 34.5 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 ELR23815.1 - 0.0032 17.1 0.0 0.0059 16.3 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain Nod1 PF17114.5 ELR23815.1 - 0.072 13.2 0.2 0.11 12.6 0.2 1.2 1 0 0 1 1 1 0 Gef2-related medial cortical node protein Nod1 HlyIII PF03006.20 ELR23816.1 - 3.2e-33 115.3 17.8 7.7e-33 114.1 17.8 1.6 1 1 0 1 1 1 1 Haemolysin-III related Oxidored_q3 PF00499.20 ELR23816.1 - 3 7.6 8.8 0.1 12.4 2.1 1.9 2 0 0 2 2 2 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 Exo_endo_phos PF03372.23 ELR23818.1 - 3.3e-08 33.4 0.1 5e-08 32.8 0.1 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family AAA_11 PF13086.6 ELR23818.1 - 0.02 14.7 2.7 0.03 14.1 2.7 1.3 1 0 0 1 1 1 0 AAA domain Borrelia_P83 PF05262.11 ELR23818.1 - 0.044 12.3 8.4 0.062 11.8 8.4 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein Tau95 PF09734.9 ELR23818.1 - 0.11 13.3 0.7 0.25 12.1 0.7 1.6 1 0 0 1 1 1 0 RNA polymerase III transcription factor (TF)IIIC subunit HTH domain DUF913 PF06025.12 ELR23818.1 - 0.13 11.2 1.0 0.2 10.6 1.0 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Atg14 PF10186.9 ELR23818.1 - 0.18 10.9 8.3 0.36 9.9 8.3 1.4 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 TMPIT PF07851.13 ELR23818.1 - 0.32 10.2 9.9 0.47 9.7 9.9 1.2 1 0 0 1 1 1 0 TMPIT-like protein DUF4407 PF14362.6 ELR23818.1 - 0.58 9.5 5.1 1.5 8.1 5.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) GAS PF13851.6 ELR23818.1 - 0.87 8.9 25.6 1.5 8.1 25.6 1.3 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding DUF1943 PF09172.11 ELR23818.1 - 1.6 7.9 6.2 2.5 7.3 6.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1943) Tho2 PF11262.8 ELR23818.1 - 2.3 7.3 11.2 4 6.6 11.2 1.3 1 0 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 DUF4446 PF14584.6 ELR23818.1 - 3 7.8 6.2 6.8 6.7 6.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4446) RR_TM4-6 PF06459.12 ELR23818.1 - 8.7 6.1 12.0 15 5.3 12.0 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 RT_RNaseH_2 PF17919.1 ELR23820.1 - 1.1e-12 47.9 0.0 3.4e-12 46.3 0.0 1.8 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 ELR23820.1 - 6.2e-09 35.7 0.0 9e-09 35.2 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH PF17917.1 ELR23820.1 - 9.9e-08 32.2 0.0 1.8e-07 31.4 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Asp_protease_2 PF13650.6 ELR23821.1 - 0.11 13.1 0.0 0.14 12.9 0.0 1.1 1 0 0 1 1 1 0 Aspartyl protease DDE_Tnp_4 PF13359.6 ELR23822.1 - 0.00017 21.3 0.0 0.00021 21.0 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_Tnp_1 PF01609.21 ELR23822.1 - 0.019 14.6 0.0 0.029 14.0 0.0 1.3 1 0 0 1 1 1 0 Transposase DDE domain SH3_9 PF14604.6 ELR23823.1 - 4.1e-05 23.3 0.0 8.8e-05 22.3 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 ELR23823.1 - 0.00023 20.7 0.0 0.00051 19.6 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 ELR23823.1 - 0.061 13.0 0.0 0.15 11.7 0.0 1.7 1 0 0 1 1 1 0 Variant SH3 domain DUF2345 PF10106.9 ELR23825.1 - 0.047 13.6 1.0 0.71 9.7 0.1 2.4 1 1 1 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2345) OmpA_membrane PF01389.17 ELR23825.1 - 0.12 12.1 0.1 0.15 11.8 0.1 1.2 1 0 0 1 1 1 0 OmpA-like transmembrane domain Ephrin_rec_like PF07699.13 ELR23826.1 - 0.00011 21.9 14.1 0.00076 19.2 2.7 2.6 2 0 0 2 2 2 2 Putative ephrin-receptor like Peptidase_M11 PF05548.11 ELR23826.1 - 0.0002 20.6 1.6 0.0004 19.6 1.6 1.4 1 0 0 1 1 1 1 Gametolysin peptidase M11 Peptidase_M66 PF10462.9 ELR23826.1 - 0.0015 17.5 0.2 0.003 16.6 0.2 1.4 1 0 0 1 1 1 1 Peptidase M66 Peptidase_M10 PF00413.24 ELR23826.1 - 0.002 18.0 0.1 0.0034 17.2 0.1 1.3 1 0 0 1 1 1 1 Matrixin Reprolysin_3 PF13582.6 ELR23826.1 - 0.0025 18.3 2.6 0.013 16.0 2.6 2.2 1 1 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_5 PF13688.6 ELR23826.1 - 0.0026 17.9 0.2 0.0061 16.7 0.2 1.6 1 0 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_4 PF13583.6 ELR23826.1 - 0.029 14.0 1.5 0.056 13.1 0.1 2.2 3 0 0 3 3 3 0 Metallo-peptidase family M12B Reprolysin-like Amnionless PF14828.6 ELR23826.1 - 0.034 13.0 0.0 0.052 12.4 0.0 1.2 1 0 0 1 1 1 0 Amnionless Reprolysin_2 PF13574.6 ELR23826.1 - 0.083 12.8 0.5 0.17 11.8 0.5 1.5 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Rax2 PF12768.7 ELR23826.1 - 0.16 11.4 0.0 0.29 10.6 0.0 1.3 1 0 0 1 1 1 0 Cortical protein marker for cell polarity SKG6 PF08693.10 ELR23826.1 - 0.6 9.6 13.7 1.7 8.1 13.7 1.7 1 0 0 1 1 1 0 Transmembrane alpha-helix domain NCD3G PF07562.14 ELR23826.1 - 3.6 7.6 9.4 3.8 7.6 3.0 2.6 2 0 0 2 2 2 0 Nine Cysteines Domain of family 3 GPCR RT_RNaseH_2 PF17919.1 ELR23828.1 - 3e-30 104.2 0.4 5e-30 103.5 0.4 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 ELR23828.1 - 2.7e-29 101.5 1.8 4.9e-29 100.7 1.8 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 ELR23828.1 - 3.2e-12 46.5 0.2 7.7e-12 45.2 0.2 1.6 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) SspB PF04386.13 ELR23828.1 - 0.16 11.9 0.5 0.6 10.0 0.1 1.9 2 0 0 2 2 2 0 Stringent starvation protein B rve PF00665.26 ELR23829.1 - 1.1e-08 35.3 0.0 1.6e-08 34.7 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 ELR23829.1 - 0.0065 16.5 0.2 0.036 14.2 0.3 2.0 2 0 0 2 2 2 1 Integrase zinc binding domain AEP1 PF17049.5 ELR23829.1 - 0.052 12.6 0.1 0.075 12.1 0.1 1.2 1 0 0 1 1 1 0 ATPase expression protein 1 DUF2403 PF10290.9 ELR23829.1 - 0.17 12.3 0.2 0.39 11.2 0.0 1.6 2 0 0 2 2 2 0 Glycine-rich protein domain (DUF2403) Capsid_N PF16903.5 ELR23830.1 - 1.1e-26 93.7 0.1 2e-22 79.8 0.1 2.1 1 1 1 2 2 2 2 Major capsid protein N-terminus Capsid_NCLDV PF04451.12 ELR23830.1 - 6.5e-12 45.6 0.1 1.2e-11 44.8 0.1 1.4 1 0 0 1 1 1 1 Large eukaryotic DNA virus major capsid protein WD40 PF00400.32 ELR23832.1 - 1.2e-15 57.6 0.3 3.4e-05 24.5 0.1 5.3 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ELR23832.1 - 2.8e-09 37.2 0.1 0.012 15.9 0.1 3.8 2 1 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain HPS3_N PF14761.6 ELR23832.1 - 0.12 11.9 0.0 0.26 10.8 0.0 1.6 2 0 0 2 2 2 0 Hermansky-Pudlak syndrome 3 Sugar_tr PF00083.24 ELR23833.1 - 6.1e-24 84.7 24.0 1e-14 54.3 5.8 2.1 2 0 0 2 2 2 2 Sugar (and other) transporter Coleoptericin PF06286.11 ELR23833.1 - 0.015 15.4 0.0 0.031 14.4 0.0 1.4 1 0 0 1 1 1 0 Coleoptericin DSPc PF00782.20 ELR23834.1 - 6.2e-31 107.0 0.0 8.4e-31 106.5 0.0 1.2 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.6 ELR23834.1 - 0.0053 16.9 0.0 0.008 16.3 0.0 1.3 1 0 0 1 1 1 1 Inositol hexakisphosphate Y_phosphatase PF00102.27 ELR23834.1 - 0.0059 16.2 0.0 0.0089 15.6 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase CDKN3 PF05706.12 ELR23834.1 - 0.17 11.6 0.0 0.27 10.9 0.0 1.3 1 0 0 1 1 1 0 Cyclin-dependent kinase inhibitor 3 (CDKN3) WD40 PF00400.32 ELR23835.1 - 1.8e-27 95.0 13.8 1.7e-07 31.8 0.2 6.8 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ELR23835.1 - 2e-10 40.8 0.1 0.00015 22.0 0.0 4.9 2 1 3 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ELR23835.1 - 0.012 14.3 0.4 0.57 8.8 0.7 2.5 2 1 1 3 3 3 0 Nucleoporin Nup120/160 TFIIB PF00382.19 ELR23836.1 - 4.1e-22 78.0 5.6 1.1e-12 47.9 0.6 2.4 2 0 0 2 2 2 2 Transcription factor TFIIB repeat TF_Zn_Ribbon PF08271.12 ELR23836.1 - 1.2e-13 50.3 1.0 2e-13 49.6 1.0 1.3 1 0 0 1 1 1 1 TFIIB zinc-binding Cyclin_C PF02984.19 ELR23836.1 - 0.0004 20.4 0.6 0.51 10.4 0.1 2.3 2 0 0 2 2 2 2 Cyclin, C-terminal domain DUF1182 PF06681.13 ELR23836.1 - 0.012 15.3 0.2 0.019 14.6 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1182) Rrf2 PF02082.20 ELR23836.1 - 0.025 14.9 1.1 9.1 6.7 0.0 2.8 3 0 0 3 3 3 0 Transcriptional regulator HTH_5 PF01022.20 ELR23836.1 - 0.035 14.0 0.0 9.2 6.2 0.0 2.6 2 0 0 2 2 2 0 Bacterial regulatory protein, arsR family Cyclin_N PF00134.23 ELR23836.1 - 0.048 13.4 0.1 0.11 12.2 0.0 1.6 2 0 0 2 2 2 0 Cyclin, N-terminal domain LacI PF00356.21 ELR23836.1 - 0.063 13.1 0.1 0.18 11.6 0.1 1.7 1 0 0 1 1 1 0 Bacterial regulatory proteins, lacI family HTH_36 PF13730.6 ELR23836.1 - 0.067 13.2 0.0 34 4.5 0.0 3.4 3 0 0 3 3 3 0 Helix-turn-helix domain CD34_antigen PF06365.12 ELR23836.1 - 0.24 11.0 0.3 0.37 10.3 0.3 1.2 1 0 0 1 1 1 0 CD34/Podocalyxin family kleA_kleC PF17383.2 ELR23837.1 - 0.071 13.4 2.1 0.071 13.4 2.1 1.9 2 0 0 2 2 2 0 Uncharacterized KorC regulated protein A tRNA-synt_1 PF00133.22 ELR23838.1 - 3.4e-209 696.1 0.2 6.4e-208 691.8 0.2 2.5 1 1 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 ELR23838.1 - 1.7e-40 138.5 0.1 1e-39 135.9 0.0 2.3 3 0 0 3 3 3 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.11 ELR23838.1 - 3.8e-16 58.8 0.4 2.5e-07 29.8 0.0 4.8 4 1 0 4 4 4 3 tRNA synthetases class I (M) tRNA-synt_1_2 PF13603.6 ELR23838.1 - 1.5e-10 40.9 0.1 3.5e-07 29.9 0.0 2.6 1 1 1 2 2 2 2 Leucyl-tRNA synthetase, Domain 2 Val_tRNA-synt_C PF10458.9 ELR23838.1 - 1.3e-08 35.0 5.6 1.3e-08 35.0 5.6 2.1 2 0 0 2 2 2 1 Valyl tRNA synthetase tRNA binding arm tRNA-synt_1e PF01406.19 ELR23838.1 - 0.03 13.7 1.4 1.5 8.1 0.0 2.7 3 0 0 3 3 3 0 tRNA synthetases class I (C) catalytic domain ABC_tran_CTD PF16326.5 ELR23838.1 - 0.39 11.0 3.5 2.1 8.7 3.5 2.3 1 1 0 1 1 1 0 ABC transporter C-terminal domain GpcrRhopsn4 PF10192.9 ELR23839.1 - 5.8e-42 143.9 21.7 1.5e-35 122.8 11.5 2.2 2 0 0 2 2 2 2 Rhodopsin-like GPCR transmembrane domain Lung_7-TM_R PF06814.13 ELR23839.1 - 0.00033 20.0 6.9 0.00033 20.0 6.9 2.1 2 0 0 2 2 2 1 Lung seven transmembrane receptor PPR_2 PF13041.6 ELR23840.1 - 7.8e-07 29.2 0.0 0.092 13.0 0.0 4.1 3 1 1 4 4 4 2 PPR repeat family PPR PF01535.20 ELR23840.1 - 0.00036 20.6 0.1 1.7 9.0 0.0 3.3 3 0 0 3 3 3 2 PPR repeat PPR_3 PF13812.6 ELR23840.1 - 0.0012 18.9 0.0 2 8.5 0.0 3.0 3 0 0 3 3 3 2 Pentatricopeptide repeat domain PPR_long PF17177.4 ELR23840.1 - 0.043 13.2 0.0 0.39 10.1 0.0 2.0 2 0 0 2 2 2 0 Pentacotripeptide-repeat region of PRORP GHMP_kinases_C PF08544.13 ELR23840.1 - 0.17 12.3 0.1 4.3 7.8 0.0 2.7 3 1 1 4 4 4 0 GHMP kinases C terminal DNA_pol_A_exo1 PF01612.20 ELR23842.1 - 6.4e-12 45.5 0.3 2.2e-11 43.8 0.1 1.8 2 0 0 2 2 2 1 3'-5' exonuclease Filament PF00038.21 ELR23842.1 - 0.00022 20.9 2.9 0.00031 20.5 2.9 1.1 1 0 0 1 1 1 1 Intermediate filament protein bZIP_1 PF00170.21 ELR23842.1 - 0.0018 18.3 1.0 0.95 9.6 0.1 2.4 1 1 1 2 2 2 2 bZIP transcription factor KIAA1430 PF13879.6 ELR23842.1 - 0.0088 16.8 0.8 0.017 15.9 0.8 1.5 1 0 0 1 1 1 1 KIAA1430 homologue CLZ PF16526.5 ELR23842.1 - 0.017 15.5 1.4 0.044 14.1 1.4 1.8 1 1 0 1 1 1 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Jnk-SapK_ap_N PF09744.9 ELR23842.1 - 0.021 15.1 0.4 0.032 14.5 0.4 1.3 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 SOGA PF11365.8 ELR23842.1 - 0.083 14.0 0.1 2.1 9.5 0.1 2.4 1 1 1 2 2 2 0 Protein SOGA BBP1_C PF15272.6 ELR23842.1 - 0.096 12.5 0.1 0.14 12.0 0.1 1.4 1 0 0 1 1 1 0 Spindle pole body component BBP1, C-terminal APG6_N PF17675.1 ELR23842.1 - 0.14 12.7 3.6 0.37 11.3 3.4 1.7 1 1 0 1 1 1 0 Apg6 coiled-coil region CCDC53 PF10152.9 ELR23842.1 - 0.15 12.5 5.8 0.19 12.1 4.4 1.9 1 1 0 1 1 1 0 Subunit CCDC53 of WASH complex TSNAXIP1_N PF15739.5 ELR23842.1 - 0.16 12.3 1.0 0.33 11.3 1.0 1.5 1 0 0 1 1 1 0 Translin-associated factor X-interacting N-terminus V_ATPase_I PF01496.19 ELR23842.1 - 0.17 9.8 0.2 0.19 9.6 0.2 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF5595 PF18077.1 ELR23842.1 - 0.24 11.5 0.5 0.91 9.6 0.5 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF5595) Uso1_p115_C PF04871.13 ELR23842.1 - 0.25 11.7 1.7 0.55 10.6 1.7 1.6 1 0 0 1 1 1 0 Uso1 / p115 like vesicle tethering protein, C terminal region bZIP_2 PF07716.15 ELR23842.1 - 0.34 11.0 5.6 0.79 9.8 0.5 2.4 2 0 0 2 2 2 0 Basic region leucine zipper PAT1 PF09770.9 ELR23842.1 - 0.46 8.7 6.6 0.55 8.4 6.6 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 TFIIA PF03153.13 ELR23842.1 - 0.77 9.7 7.8 0.83 9.6 7.8 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF5327 PF17261.2 ELR23842.1 - 0.97 10.2 3.5 1.9 9.3 3.1 1.6 1 1 0 1 1 1 0 Family of unknown function (DUF5327) DUF1192 PF06698.11 ELR23842.1 - 3 7.9 8.3 4.8 7.3 1.6 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF1192) Mto2_bdg PF12808.7 ELR23842.1 - 8.9 6.7 9.1 1.4 9.3 4.6 2.0 2 1 0 2 2 1 0 Micro-tubular organiser Mto1 C-term Mto2-binding region PAS_9 PF13426.7 ELR23843.1 - 0.0041 17.4 0.0 0.011 15.9 0.0 1.7 1 0 0 1 1 1 1 PAS domain HAUS5 PF14817.6 ELR23843.1 - 0.021 13.6 0.8 0.03 13.1 0.8 1.1 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 5 ATG16 PF08614.11 ELR23843.1 - 0.022 15.0 3.2 0.022 15.0 3.2 2.3 2 0 0 2 2 2 0 Autophagy protein 16 (ATG16) PAS_3 PF08447.12 ELR23843.1 - 0.064 13.6 0.0 0.14 12.5 0.0 1.5 1 0 0 1 1 1 0 PAS fold Med4 PF10018.9 ELR23843.1 - 0.064 12.9 3.6 0.17 11.6 0.5 2.3 2 0 0 2 2 2 0 Vitamin-D-receptor interacting Mediator subunit 4 PAS PF00989.25 ELR23843.1 - 0.076 13.0 0.1 0.24 11.4 0.0 1.8 2 0 0 2 2 2 0 PAS fold PSD2 PF07624.11 ELR23843.1 - 0.12 12.1 0.4 0.4 10.5 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1585) GvpG PF05120.12 ELR23843.1 - 0.2 11.7 1.4 0.45 10.6 0.1 2.2 2 0 0 2 2 2 0 Gas vesicle protein G DUF724 PF05266.14 ELR23843.1 - 0.67 9.8 3.1 13 5.5 2.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF724) ZapB PF06005.12 ELR23843.1 - 1.4 9.4 14.3 0.12 12.8 8.0 2.1 2 0 0 2 2 2 0 Cell division protein ZapB Seryl_tRNA_N PF02403.22 ELR23843.1 - 1.6 9.0 6.4 0.52 10.6 1.9 2.1 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain Cnn_1N PF07989.11 ELR23843.1 - 1.7 8.9 8.7 0.24 11.6 2.6 2.2 2 0 0 2 2 2 0 Centrosomin N-terminal motif 1 DHR10 PF18595.1 ELR23843.1 - 2.3 8.3 13.2 7.9 6.6 5.3 2.3 2 0 0 2 2 2 0 Designed helical repeat protein 10 domain Pox_A_type_inc PF04508.12 ELR23843.1 - 4.8 7.2 8.3 0.91 9.5 2.1 2.5 2 0 0 2 2 2 0 Viral A-type inclusion protein repeat PAS PF00989.25 ELR23844.1 - 0.0021 18.0 0.0 0.0064 16.5 0.0 1.7 2 0 0 2 2 2 1 PAS fold PAS_9 PF13426.7 ELR23844.1 - 0.0055 17.0 0.0 0.013 15.8 0.0 1.6 1 0 0 1 1 1 1 PAS domain TALPID3 PF15324.6 ELR23844.1 - 0.011 13.4 4.5 0.016 12.9 4.5 1.1 1 0 0 1 1 1 0 Hedgehog signalling target ZapB PF06005.12 ELR23844.1 - 0.034 14.6 5.5 0.065 13.7 5.5 1.5 1 0 0 1 1 1 0 Cell division protein ZapB DUF4763 PF15960.5 ELR23844.1 - 0.052 12.9 5.8 0.089 12.1 5.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4763) PAS_3 PF08447.12 ELR23844.1 - 0.12 12.7 0.0 0.23 11.8 0.0 1.5 1 0 0 1 1 1 0 PAS fold Kinesin_assoc PF16183.5 ELR23844.1 - 0.48 10.6 2.7 0.86 9.7 2.1 1.6 2 0 0 2 2 2 0 Kinesin-associated GvpG PF05120.12 ELR23844.1 - 0.69 10.0 2.6 0.47 10.5 0.1 1.8 2 0 0 2 2 2 0 Gas vesicle protein G Herpes_capsid PF06112.11 ELR23844.1 - 2.5 8.2 11.1 6.1 6.9 11.1 1.7 1 0 0 1 1 1 0 Gammaherpesvirus capsid protein Pkinase PF00069.25 ELR23845.1 - 9.9e-39 133.3 0.0 3.1e-28 98.9 0.0 2.9 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ELR23845.1 - 4.9e-18 65.3 0.0 8e-11 41.7 0.1 3.3 3 0 0 3 3 3 3 Protein tyrosine kinase FTA2 PF13095.6 ELR23845.1 - 0.0081 15.8 0.0 0.94 9.1 0.0 2.4 2 0 0 2 2 2 1 Kinetochore Sim4 complex subunit FTA2 UPF0242 PF06785.11 ELR23845.1 - 0.047 13.8 0.6 0.13 12.4 0.6 1.7 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Spc7 PF08317.11 ELR23845.1 - 0.059 12.2 2.3 0.2 10.5 2.3 1.8 1 0 0 1 1 1 0 Spc7 kinetochore protein SlyX PF04102.12 ELR23845.1 - 0.075 13.7 0.5 0.075 13.7 0.5 2.1 2 0 0 2 2 2 0 SlyX DUF4404 PF14357.6 ELR23845.1 - 1.6 9.4 7.5 0.66 10.7 2.1 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4404) PI3K_1B_p101 PF10486.9 ELR23845.1 - 7.7 4.2 8.0 12 3.5 8.0 1.2 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit Dicty_REP PF05086.12 ELR23846.1 - 0.027 12.5 4.6 0.026 12.5 4.6 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein MCM_bind PF09739.9 ELR23846.1 - 0.17 10.3 2.9 0.23 9.9 2.9 1.1 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor Pex14_N PF04695.13 ELR23846.1 - 0.93 10.1 12.8 0.036 14.7 5.5 2.0 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region ATG16 PF08614.11 ELR23847.1 - 0.00062 20.1 2.7 0.00096 19.4 2.7 1.2 1 0 0 1 1 1 1 Autophagy protein 16 (ATG16) Zn_clus PF00172.18 ELR23847.1 - 0.0033 17.5 9.7 0.0033 17.5 9.7 2.5 1 1 1 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain PAS PF00989.25 ELR23847.1 - 0.011 15.7 0.0 0.043 13.8 0.0 1.9 1 1 0 1 1 1 0 PAS fold MEKHLA PF08670.11 ELR23847.1 - 0.012 15.5 0.0 0.022 14.7 0.0 1.3 1 0 0 1 1 1 0 MEKHLA domain Tmemb_cc2 PF10267.9 ELR23847.1 - 0.06 12.5 0.0 0.082 12.0 0.0 1.1 1 0 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein Baculo_PEP_C PF04513.12 ELR23847.1 - 0.21 11.6 0.2 0.33 11.0 0.2 1.2 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus PAS_9 PF13426.7 ELR23848.1 - 0.006 16.8 0.0 0.017 15.3 0.0 1.8 1 0 0 1 1 1 1 PAS domain PAS PF00989.25 ELR23848.1 - 0.0067 16.4 0.0 0.043 13.8 0.0 2.3 2 0 0 2 2 2 1 PAS fold PAS_8 PF13188.7 ELR23848.1 - 0.012 15.6 0.0 0.033 14.2 0.0 1.7 1 0 0 1 1 1 0 PAS domain HTH_32 PF13565.6 ELR23848.1 - 0.16 12.6 1.5 0.23 12.1 0.4 1.9 2 0 0 2 2 2 0 Homeodomain-like domain PAS_9 PF13426.7 ELR23849.1 - 0.00027 21.1 0.0 0.00078 19.7 0.0 1.7 2 0 0 2 2 2 1 PAS domain PAS PF00989.25 ELR23849.1 - 0.0011 19.0 0.8 0.004 17.2 0.0 2.3 3 0 0 3 3 3 1 PAS fold PAS_3 PF08447.12 ELR23849.1 - 0.0026 18.0 0.0 0.0067 16.7 0.0 1.7 1 0 0 1 1 1 1 PAS fold Zn_clus PF00172.18 ELR23849.1 - 0.014 15.5 9.3 0.027 14.6 9.3 1.5 1 0 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain Ribosomal_L19e PF01280.20 ELR23849.1 - 0.041 13.9 0.2 0.13 12.3 0.2 1.8 1 0 0 1 1 1 0 Ribosomal protein L19e Macoilin PF09726.9 ELR23849.1 - 5.4 5.5 5.6 9 4.7 5.6 1.4 1 0 0 1 1 1 0 Macoilin family PAS_3 PF08447.12 ELR23850.1 - 0.00075 19.7 0.0 0.013 15.8 0.0 2.7 2 1 0 2 2 2 1 PAS fold PAS_9 PF13426.7 ELR23850.1 - 0.0018 18.5 0.0 0.0082 16.4 0.0 2.0 1 1 0 1 1 1 1 PAS domain PAS PF00989.25 ELR23850.1 - 0.02 14.9 0.0 0.17 11.9 0.0 2.2 2 1 0 2 2 2 0 PAS fold Tektin PF03148.14 ELR23850.1 - 0.086 11.6 2.3 0.12 11.1 2.3 1.1 1 0 0 1 1 1 0 Tektin family PAS_8 PF13188.7 ELR23850.1 - 0.1 12.7 0.0 0.24 11.4 0.0 1.7 1 0 0 1 1 1 0 PAS domain CCDC24 PF15669.5 ELR23850.1 - 0.44 10.4 4.0 0.21 11.5 0.1 2.0 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 24 family Red1 PF07964.11 ELR23851.1 - 0.55 8.4 22.9 0.72 8.0 22.9 1.1 1 0 0 1 1 1 0 Rec10 / Red1 Pkinase_Tyr PF07714.17 ELR23852.1 - 4.8e-123 409.5 0.0 8.9e-63 212.0 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 ELR23852.1 - 9e-106 353.1 0.0 5.2e-52 176.8 0.0 3.1 2 1 0 2 2 2 2 Protein kinase domain PBP_like_2 PF12849.7 ELR23852.1 - 3.1e-27 96.0 10.4 4.5e-20 72.5 5.0 2.8 2 1 0 2 2 2 2 PBP superfamily domain Guanylate_cyc PF00211.20 ELR23852.1 - 2.3e-16 59.9 0.0 4e-16 59.2 0.0 1.3 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain APH PF01636.23 ELR23852.1 - 5.2e-07 29.8 1.9 0.00011 22.2 0.2 3.1 2 1 1 3 3 3 2 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 ELR23852.1 - 0.00013 20.9 0.0 0.33 9.7 0.0 2.9 3 0 0 3 3 3 2 Fungal protein kinase Haspin_kinase PF12330.8 ELR23852.1 - 0.00013 21.0 0.0 0.038 12.9 0.0 2.5 2 1 0 2 2 2 2 Haspin like kinase domain Kinase-like PF14531.6 ELR23852.1 - 0.00021 20.7 0.0 0.19 11.0 0.0 3.0 3 0 0 3 3 3 1 Kinase-like FTA2 PF13095.6 ELR23852.1 - 0.019 14.6 0.1 0.35 10.4 0.0 2.6 2 1 1 3 3 3 0 Kinetochore Sim4 complex subunit FTA2 RIO1 PF01163.22 ELR23852.1 - 0.02 14.5 1.3 1.5 8.4 0.5 2.7 2 1 0 2 2 2 0 RIO1 family Seadorna_VP7 PF07387.11 ELR23852.1 - 0.1 11.6 0.1 0.32 10.0 0.0 1.7 2 0 0 2 2 2 0 Seadornavirus VP7 EGF_2 PF07974.13 ELR23852.1 - 0.35 11.3 10.9 0.65 10.4 10.9 1.5 1 0 0 1 1 1 0 EGF-like domain UAA PF08449.11 ELR23853.1 - 3.3e-37 128.3 8.6 8.7e-35 120.4 4.5 2.1 2 0 0 2 2 2 2 UAA transporter family EamA PF00892.20 ELR23853.1 - 0.0042 17.3 5.6 0.0042 17.3 5.6 3.0 3 1 0 3 3 3 2 EamA-like transporter family CRT-like PF08627.10 ELR23853.1 - 0.015 14.3 1.0 0.015 14.3 1.0 2.4 2 1 1 3 3 3 0 CRT-like, chloroquine-resistance transporter-like SET PF00856.28 ELR23854.1 - 0.0014 19.0 0.5 0.012 16.0 0.1 2.4 2 1 0 2 2 2 1 SET domain Zn-ribbon_8 PF09723.10 ELR23856.1 - 0.036 14.2 0.1 0.096 12.8 0.1 1.7 1 0 0 1 1 1 0 Zinc ribbon domain CpXC PF14353.6 ELR23856.1 - 0.039 14.0 0.4 0.039 14.0 0.4 2.4 1 1 1 2 2 2 0 CpXC protein RNase_H2_suC PF08615.11 ELR23856.1 - 0.059 13.6 7.0 0.14 12.3 7.0 1.6 1 1 0 1 1 1 0 Ribonuclease H2 non-catalytic subunit (Ylr154p-like) E7 PF00527.18 ELR23856.1 - 0.093 12.9 9.4 0.49 10.6 0.1 2.2 2 0 0 2 2 2 0 E7 protein, Early protein Pkinase_Tyr PF07714.17 ELR23857.1 - 7.4e-64 215.5 0.0 9.5e-64 215.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ELR23857.1 - 6e-53 179.9 0.0 9.3e-53 179.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Exosortase_EpsH PF09721.10 ELR23857.1 - 0.00033 20.3 2.3 0.00033 20.3 2.3 2.7 3 0 0 3 3 3 1 Transmembrane exosortase (Exosortase_EpsH) Pkinase_fungal PF17667.1 ELR23857.1 - 0.0013 17.6 0.0 0.002 17.0 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase DUF4064 PF13273.6 ELR23857.1 - 0.023 15.0 5.3 0.21 11.9 0.3 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF4064) APH PF01636.23 ELR23857.1 - 0.033 14.1 0.2 0.087 12.7 0.2 1.6 1 1 0 1 1 1 0 Phosphotransferase enzyme family Haspin_kinase PF12330.8 ELR23857.1 - 0.052 12.5 0.0 0.091 11.7 0.0 1.3 1 0 0 1 1 1 0 Haspin like kinase domain DUF973 PF06157.11 ELR23857.1 - 0.48 9.4 2.0 0.65 9.0 0.3 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF973) DUF1084 PF06454.11 ELR23857.1 - 1 8.7 16.2 0.097 12.0 2.3 2.8 4 0 0 4 4 4 0 Protein of unknown function (DUF1084) ABC2_membrane_3 PF12698.7 ELR23857.1 - 7.9 5.5 9.9 0.54 9.3 2.6 2.4 2 0 0 2 2 2 0 ABC-2 family transporter protein PAS_8 PF13188.7 ELR23861.1 - 0.049 13.7 0.0 0.11 12.5 0.0 1.7 1 1 0 1 1 1 0 PAS domain TP2 PF01254.18 ELR23862.1 - 0.08 13.6 3.1 0.095 13.3 3.1 1.2 1 0 0 1 1 1 0 Nuclear transition protein 2 PAS PF00989.25 ELR23863.1 - 0.15 12.1 0.0 0.24 11.4 0.0 1.3 1 0 0 1 1 1 0 PAS fold PAS_3 PF08447.12 ELR23863.1 - 0.17 12.2 0.0 0.87 9.9 0.0 2.0 1 1 0 1 1 1 0 PAS fold PAS_3 PF08447.12 ELR23864.1 - 0.0035 17.6 0.0 0.008 16.4 0.0 1.6 1 1 0 1 1 1 1 PAS fold PAS_9 PF13426.7 ELR23864.1 - 0.082 13.2 0.0 0.24 11.7 0.0 1.7 1 1 0 1 1 1 0 PAS domain Tmemb_cc2 PF10267.9 ELR23864.1 - 0.3 10.2 0.5 2.1 7.4 0.2 1.9 2 0 0 2 2 2 0 Predicted transmembrane and coiled-coil 2 protein tRNA_edit PF04073.15 ELR23865.1 - 9.4e-10 38.6 0.0 7.1e-09 35.8 0.0 2.2 2 1 0 2 2 2 1 Aminoacyl-tRNA editing domain LIM PF00412.22 ELR23866.1 - 1.1e-11 44.7 7.7 1.9e-11 44.0 7.7 1.4 1 0 0 1 1 1 1 LIM domain DUF35_N PF12172.8 ELR23866.1 - 0.0086 15.9 0.2 5.7 6.9 0.1 3.3 3 0 0 3 3 3 1 Rubredoxin-like zinc ribbon domain (DUF35_N) DUF930 PF06059.12 ELR23866.1 - 0.03 14.9 2.0 0.05 14.2 0.9 1.9 1 1 1 2 2 2 0 Domain of Unknown Function (DUF930) NCD3G PF07562.14 ELR23866.1 - 7.7 6.6 9.0 30 4.7 6.7 2.4 1 1 1 2 2 2 0 Nine Cysteines Domain of family 3 GPCR PAS_9 PF13426.7 ELR23867.1 - 0.0015 18.8 0.0 0.003 17.8 0.0 1.4 1 0 0 1 1 1 1 PAS domain Zn_clus PF00172.18 ELR23867.1 - 0.0032 17.6 10.3 0.0061 16.7 10.3 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain PAS_8 PF13188.7 ELR23867.1 - 0.06 13.4 0.0 0.14 12.2 0.0 1.6 1 0 0 1 1 1 0 PAS domain MEKHLA PF08670.11 ELR23868.1 - 0.024 14.5 0.0 0.041 13.8 0.0 1.4 1 0 0 1 1 1 0 MEKHLA domain PAS_9 PF13426.7 ELR23869.1 - 0.0076 16.5 0.0 0.025 14.8 0.0 1.9 1 1 0 1 1 1 1 PAS domain Zn_clus PF00172.18 ELR23869.1 - 0.14 12.3 0.8 0.25 11.5 0.8 1.3 1 0 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain PAS_3 PF08447.12 ELR23869.1 - 0.17 12.2 0.0 0.49 10.7 0.0 1.7 2 0 0 2 2 2 0 PAS fold KorB PF08535.10 ELR23869.1 - 0.18 11.9 0.4 0.33 11.0 0.4 1.4 1 0 0 1 1 1 0 KorB domain ATG16 PF08614.11 ELR23869.1 - 0.24 11.6 6.8 0.47 10.7 6.8 1.4 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) ZapB PF06005.12 ELR23869.1 - 0.26 11.7 8.4 0.46 11.0 8.4 1.3 1 0 0 1 1 1 0 Cell division protein ZapB Acetyltransf_1 PF00583.25 ELR23870.1 - 1e-09 38.6 0.1 1.7e-09 38.0 0.1 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_9 PF13527.7 ELR23870.1 - 4e-08 33.4 0.0 4.8e-08 33.1 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 ELR23870.1 - 9.4e-07 29.2 0.0 1.4e-06 28.6 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 ELR23870.1 - 0.0068 16.3 0.0 0.0099 15.8 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 ELR23870.1 - 0.029 14.4 0.0 0.07 13.1 0.0 1.6 1 0 0 1 1 1 0 FR47-like protein Acetyltransf_CG PF14542.6 ELR23870.1 - 0.064 13.4 0.0 0.12 12.5 0.0 1.5 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase Peptidase_C39_2 PF13529.6 ELR23873.1 - 1.6e-11 44.9 0.0 3.6e-11 43.8 0.0 1.6 1 1 0 1 1 1 1 Peptidase_C39 like family Peptidase_C70 PF12385.8 ELR23873.1 - 2e-08 34.3 0.0 1.3e-07 31.7 0.0 2.1 1 1 0 1 1 1 1 Papain-like cysteine protease AvrRpt2 DUF3335 PF11814.8 ELR23873.1 - 0.00015 21.3 0.0 0.00025 20.6 0.0 1.3 1 0 0 1 1 1 1 Peptidase_C39 like family Guanylate_cyc_2 PF09778.9 ELR23873.1 - 0.0076 15.6 0.0 0.15 11.4 0.0 2.3 2 1 1 3 3 3 1 Guanylylate cyclase PALP PF00291.25 ELR23874.1 - 3e-73 246.8 0.0 3.7e-73 246.5 0.0 1.0 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme ADH_zinc_N PF00107.26 ELR23874.1 - 0.014 15.4 0.1 0.39 10.7 0.0 3.0 2 2 0 2 2 2 0 Zinc-binding dehydrogenase MT-A70 PF05063.14 ELR23875.1 - 7.4e-40 136.7 0.2 2.2e-39 135.1 0.0 1.8 2 0 0 2 2 2 1 MT-A70 ZZ PF00569.17 ELR23875.1 - 4.2e-29 100.1 43.3 3.9e-08 33.0 8.7 4.6 4 0 0 4 4 4 4 Zinc finger, ZZ type R3H-assoc PF13902.6 ELR23875.1 - 0.13 12.6 2.3 0.56 10.6 1.7 2.3 2 0 0 2 2 2 0 R3H-associated N-terminal domain F-box-like PF12937.7 ELR23876.1 - 8.7e-06 25.5 0.2 2.6e-05 24.0 0.2 1.9 1 1 0 1 1 1 1 F-box-like F-box PF00646.33 ELR23876.1 - 0.0018 18.1 0.3 0.0066 16.3 0.3 2.0 1 1 0 1 1 1 1 F-box domain RFX_DNA_binding PF02257.15 ELR23877.1 - 1.3e-18 67.4 1.5 2.8e-18 66.3 0.4 2.1 2 0 0 2 2 2 1 RFX DNA-binding domain Cdc6_C PF09079.11 ELR23877.1 - 0.01 15.8 0.1 0.065 13.2 0.0 2.1 1 1 1 2 2 2 0 CDC6, C terminal winged helix domain SOG2 PF10428.9 ELR23877.1 - 1.5 7.9 26.0 1.9 7.6 26.0 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein GalKase_gal_bdg PF10509.9 ELR23878.1 - 2.3e-20 71.9 0.0 3.9e-20 71.2 0.0 1.4 1 0 0 1 1 1 1 Galactokinase galactose-binding signature GHMP_kinases_N PF00288.26 ELR23878.1 - 2.6e-15 56.4 0.7 6.3e-15 55.2 0.7 1.7 1 0 0 1 1 1 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.13 ELR23878.1 - 8.3e-10 38.9 0.0 2.2e-09 37.6 0.0 1.8 1 0 0 1 1 1 1 GHMP kinases C terminal zf-His_Me_endon PF05551.11 ELR23878.1 - 0.071 13.3 0.0 0.14 12.4 0.0 1.4 1 0 0 1 1 1 0 Zinc-binding loop region of homing endonuclease Nup35_RRM_2 PF14605.6 ELR23879.1 - 5.2e-10 39.2 0.0 0.00047 20.1 0.0 2.4 2 0 0 2 2 2 2 Nup53/35/40-type RNA recognition motif RRM_1 PF00076.22 ELR23879.1 - 1.2e-08 34.7 0.1 0.00023 20.9 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PWI PF01480.17 ELR23879.1 - 4.3e-05 23.7 0.8 7.6e-05 23.0 0.1 1.9 2 0 0 2 2 2 1 PWI domain RRM_occluded PF16842.5 ELR23879.1 - 0.00021 21.1 0.1 0.075 12.9 0.0 2.9 3 0 0 3 3 3 1 Occluded RNA-recognition motif RRM_3 PF08777.11 ELR23879.1 - 0.037 14.1 0.1 20 5.3 0.0 3.1 2 0 0 2 2 2 0 RNA binding motif CENP-H PF05837.12 ELR23879.1 - 0.53 10.7 10.5 0.77 10.2 6.4 2.8 2 0 0 2 2 2 0 Centromere protein H (CENP-H) KxDL PF10241.9 ELR23879.1 - 3.4 8.0 10.4 0.33 11.3 5.1 2.0 2 0 0 2 2 2 0 Uncharacterized conserved protein TMPIT PF07851.13 ELR23879.1 - 7 5.8 6.3 14 4.8 6.3 1.4 1 0 0 1 1 1 0 TMPIT-like protein KTI12 PF08433.10 ELR23880.1 - 1.9e-21 76.7 0.0 8.2e-21 74.7 0.0 1.8 1 1 0 1 1 1 1 Chromatin associated protein KTI12 AAA_33 PF13671.6 ELR23880.1 - 8.5e-15 55.2 3.1 4.5e-14 52.8 0.2 2.8 2 1 0 2 2 2 1 AAA domain AAA_18 PF13238.6 ELR23880.1 - 6.7e-05 23.4 0.2 0.00027 21.5 0.0 2.2 2 1 0 2 2 2 1 AAA domain AAA_22 PF13401.6 ELR23880.1 - 0.00011 22.5 0.2 0.00037 20.8 0.0 2.1 2 1 0 2 2 2 1 AAA domain AAA PF00004.29 ELR23880.1 - 0.00016 22.1 0.0 0.015 15.7 0.0 2.4 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) APS_kinase PF01583.20 ELR23880.1 - 0.0011 18.9 0.2 0.27 11.1 0.0 2.4 2 0 0 2 2 2 1 Adenylylsulphate kinase MMR_HSR1 PF01926.23 ELR23880.1 - 0.0025 17.9 0.0 0.0084 16.2 0.0 1.8 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_17 PF13207.6 ELR23880.1 - 0.0026 18.2 0.9 0.023 15.1 0.0 2.8 2 1 0 2 2 2 1 AAA domain ABC_tran PF00005.27 ELR23880.1 - 0.0077 16.8 0.0 0.017 15.7 0.0 1.7 1 0 0 1 1 1 1 ABC transporter Ploopntkinase3 PF18751.1 ELR23880.1 - 0.023 14.6 0.0 0.051 13.5 0.0 1.6 1 0 0 1 1 1 0 P-loop Nucleotide Kinase3 AAA_16 PF13191.6 ELR23880.1 - 0.024 15.0 5.7 0.41 11.0 5.7 2.8 1 1 0 1 1 1 0 AAA ATPase domain dNK PF01712.19 ELR23880.1 - 0.027 14.3 0.2 7.9 6.3 0.0 3.0 3 0 0 3 3 3 0 Deoxynucleoside kinase IstB_IS21 PF01695.17 ELR23880.1 - 0.03 14.0 0.1 0.4 10.4 0.0 2.4 2 0 0 2 2 2 0 IstB-like ATP binding protein MeaB PF03308.16 ELR23880.1 - 0.036 13.0 0.2 0.19 10.7 0.0 2.0 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB RNA_helicase PF00910.22 ELR23880.1 - 0.043 14.2 0.0 0.083 13.3 0.0 1.4 1 0 0 1 1 1 0 RNA helicase Mg_chelatase PF01078.21 ELR23880.1 - 0.053 12.9 0.1 0.14 11.6 0.0 1.6 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI NACHT PF05729.12 ELR23880.1 - 0.063 13.2 0.0 0.16 11.9 0.0 1.7 1 0 0 1 1 1 0 NACHT domain RsgA_GTPase PF03193.16 ELR23880.1 - 0.068 13.1 0.0 0.13 12.2 0.0 1.4 1 0 0 1 1 1 0 RsgA GTPase Zeta_toxin PF06414.12 ELR23880.1 - 0.081 12.2 0.0 0.18 11.1 0.0 1.5 1 0 0 1 1 1 0 Zeta toxin Arf PF00025.21 ELR23880.1 - 0.085 12.3 0.0 0.15 11.5 0.0 1.3 1 0 0 1 1 1 0 ADP-ribosylation factor family Viral_helicase1 PF01443.18 ELR23880.1 - 0.11 12.2 0.0 0.23 11.1 0.0 1.5 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase cobW PF02492.19 ELR23880.1 - 0.12 12.0 0.0 0.17 11.5 0.0 1.3 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain CPT PF07931.12 ELR23880.1 - 0.13 12.1 3.9 0.78 9.6 0.3 3.1 1 1 0 2 2 2 0 Chloramphenicol phosphotransferase-like protein AAA_5 PF07728.14 ELR23880.1 - 0.14 12.2 0.0 0.31 11.0 0.0 1.6 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) DnaG_DnaB_bind PF08278.11 ELR23880.1 - 0.27 11.9 3.9 1.6 9.3 0.0 3.0 3 1 1 4 4 4 0 DNA primase DnaG DnaB-binding AAA_28 PF13521.6 ELR23880.1 - 0.52 10.5 6.5 0.088 13.1 0.7 2.8 1 1 2 3 3 3 0 AAA domain ATP12 PF07542.11 ELR23882.1 - 5.7e-20 71.7 0.0 8.4e-20 71.2 0.0 1.2 1 0 0 1 1 1 1 ATP12 chaperone protein Atx10homo_assoc PF09759.9 ELR23884.1 - 4.1e-39 132.6 2.8 3.1e-34 117.0 0.1 3.5 2 1 0 2 2 2 2 Spinocerebellar ataxia type 10 protein domain Arm_2 PF04826.13 ELR23884.1 - 0.00021 20.8 0.0 0.015 14.7 0.0 2.5 2 0 0 2 2 2 1 Armadillo-like RYDR_ITPR PF01365.21 ELR23884.1 - 0.00071 19.1 1.1 0.0049 16.3 0.4 2.3 2 0 0 2 2 2 1 RIH domain WAPL PF07814.13 ELR23884.1 - 0.051 12.4 3.2 0.15 10.8 3.3 1.7 1 1 0 1 1 1 0 Wings apart-like protein regulation of heterochromatin RIH_assoc PF08454.11 ELR23884.1 - 0.053 13.4 2.2 0.062 13.2 0.6 2.0 2 0 0 2 2 2 0 RyR and IP3R Homology associated TMEM154 PF15102.6 ELR23884.1 - 0.076 12.9 0.2 0.49 10.3 0.2 2.0 2 0 0 2 2 2 0 TMEM154 protein family DUF383 PF04063.14 ELR23884.1 - 0.14 11.9 0.9 7.9 6.1 0.0 3.5 3 1 1 4 4 4 0 Domain of unknown function (DUF383) SH3_1 PF00018.28 ELR23885.1 - 1.5e-26 91.7 2.1 4e-12 45.6 0.0 2.4 2 0 0 2 2 2 2 SH3 domain SH3_9 PF14604.6 ELR23885.1 - 7.6e-23 80.1 3.5 3.9e-11 42.6 0.4 2.4 2 0 0 2 2 2 2 Variant SH3 domain SH3_2 PF07653.17 ELR23885.1 - 3.4e-20 71.5 0.7 1.8e-10 40.3 0.1 2.4 2 0 0 2 2 2 2 Variant SH3 domain C2 PF00168.30 ELR23885.1 - 2.5e-09 37.4 0.2 1.2e-08 35.2 0.1 2.1 1 1 0 2 2 2 1 C2 domain 2_5_RNA_ligase2 PF13563.6 ELR23886.1 - 3.4e-19 69.3 2.0 1.1e-18 67.6 2.0 1.7 1 1 0 1 1 1 1 2'-5' RNA ligase superfamily LigT_PEase PF02834.16 ELR23886.1 - 9.1e-07 29.0 1.7 0.012 15.8 0.1 2.2 1 1 1 2 2 2 2 LigT like Phosphoesterase DIL PF01843.19 ELR23887.1 - 2.6e-20 72.6 0.0 1.6e-19 70.1 0.0 2.6 1 0 0 1 1 1 1 DIL domain NT-C2 PF10358.9 ELR23887.1 - 1.8e-17 63.4 0.2 5.8e-17 61.8 0.1 1.9 2 0 0 2 2 2 1 N-terminal C2 in EEIG1 and EHBP1 proteins DUF641 PF04859.12 ELR23887.1 - 0.27 11.5 0.0 0.27 11.5 0.0 15.8 4 2 11 15 15 15 0 Plant protein of unknown function (DUF641) zf-C2HC5 PF06221.13 ELR23888.1 - 4.8e-09 36.1 2.3 9.3e-09 35.1 2.3 1.4 1 0 0 1 1 1 1 Putative zinc finger motif, C2HC5-type PP1_inhibitor PF05361.12 ELR23888.1 - 0.0047 16.9 0.3 0.016 15.2 0.3 1.9 1 0 0 1 1 1 1 PKC-activated protein phosphatase-1 inhibitor NAGidase PF07555.13 ELR23888.1 - 0.009 15.4 0.0 0.029 13.7 0.0 1.9 2 0 0 2 2 2 1 beta-N-acetylglucosaminidase NPA PF16469.5 ELR23888.1 - 0.22 12.1 0.1 0.22 12.1 0.1 2.6 3 0 0 3 3 3 0 Nematode polyprotein allergen ABA-1 PWI PF01480.17 ELR23888.1 - 0.64 10.4 2.8 2.5 8.5 0.3 2.6 2 1 1 3 3 3 0 PWI domain DUF1772 PF08592.11 ELR23889.1 - 0.00035 20.9 0.3 0.00056 20.2 0.3 1.5 1 1 0 1 1 1 1 Domain of unknown function (DUF1772) YfhO PF09586.10 ELR23889.1 - 0.0013 17.1 0.5 0.0016 16.8 0.5 1.0 1 0 0 1 1 1 1 Bacterial membrane protein YfhO DUF2339 PF10101.9 ELR23889.1 - 0.0016 17.1 3.2 0.002 16.8 3.2 1.0 1 0 0 1 1 1 1 Predicted membrane protein (DUF2339) Acyl_transf_3 PF01757.22 ELR23889.1 - 0.015 14.4 2.2 0.019 14.1 2.2 1.0 1 0 0 1 1 1 0 Acyltransferase family Peptidase_U4 PF03419.13 ELR23889.1 - 0.02 14.2 3.0 0.024 13.9 3.0 1.1 1 0 0 1 1 1 0 Sporulation factor SpoIIGA DUF2723 PF11028.8 ELR23889.1 - 0.054 13.4 4.6 0.072 13.0 4.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2723) TIC20 PF16166.5 ELR23889.1 - 0.067 13.0 2.4 0.087 12.6 2.1 1.4 1 1 0 1 1 1 0 Chloroplast import apparatus Tic20-like DUF2157 PF09925.9 ELR23889.1 - 0.13 12.0 3.6 0.21 11.4 3.6 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2157) SLATT_3 PF18184.1 ELR23889.1 - 0.14 12.3 1.7 0.15 12.2 0.6 1.6 2 0 0 2 2 2 0 SMODS and SLOG-associating 2TM effector domain 3 DUF3278 PF11683.8 ELR23889.1 - 0.16 12.1 3.1 0.14 12.3 2.0 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3278) DUF2070 PF09843.9 ELR23889.1 - 0.39 8.9 7.6 0.53 8.5 7.6 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) DUF4131 PF13567.6 ELR23889.1 - 0.44 10.2 4.2 0.15 11.7 1.4 1.7 1 1 1 2 2 2 0 Domain of unknown function (DUF4131) PMT_2 PF13231.6 ELR23889.1 - 0.57 10.4 10.4 1.2 9.4 10.4 1.4 1 1 0 1 1 1 0 Dolichyl-phosphate-mannose-protein mannosyltransferase DUF3021 PF11457.8 ELR23889.1 - 0.68 10.3 5.5 1 9.7 5.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3021) DUF4149 PF13664.6 ELR23889.1 - 1.6 9.1 5.9 0.61 10.4 1.5 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4149) Wzy_C PF04932.15 ELR23889.1 - 9.9 5.8 7.0 69 3.0 7.1 2.0 1 1 0 1 1 1 0 O-Antigen ligase DUF2076 PF09849.9 ELR23890.1 - 6.7e-12 46.0 8.6 8e-12 45.8 8.6 1.1 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2076) CHCH PF06747.13 ELR23890.1 - 5.8e-05 23.1 3.4 8.5e-05 22.6 3.4 1.3 1 0 0 1 1 1 1 CHCH domain COX6B PF02297.17 ELR23890.1 - 0.021 15.1 3.4 0.051 13.8 3.4 1.6 1 1 1 2 2 2 0 Cytochrome oxidase c subunit VIb Ras PF00071.22 ELR23891.1 - 3.4e-50 169.8 1.4 3.9e-47 159.9 1.4 2.0 1 1 0 1 1 1 1 Ras family Roc PF08477.13 ELR23891.1 - 6.5e-29 100.6 0.3 3.2e-28 98.4 0.3 2.0 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR23891.1 - 9.4e-12 44.7 0.3 2.1e-09 37.1 0.3 2.1 1 1 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 ELR23891.1 - 1.2e-07 31.8 0.1 4.1e-07 30.1 0.0 1.8 1 1 0 2 2 2 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 ELR23891.1 - 1.7e-05 24.5 0.6 0.0084 15.7 0.6 3.2 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 ELR23891.1 - 4.9e-05 22.8 0.2 6.5e-05 22.4 0.2 1.4 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 ELR23891.1 - 9.7e-05 22.3 0.0 0.0029 17.5 0.0 2.1 2 0 0 2 2 2 1 RsgA GTPase PduV-EutP PF10662.9 ELR23891.1 - 0.001 18.8 0.2 0.077 12.7 0.1 2.2 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation Septin PF00735.18 ELR23891.1 - 0.0062 15.9 0.5 0.012 14.9 0.1 1.6 2 0 0 2 2 2 1 Septin SRPRB PF09439.10 ELR23891.1 - 0.0071 15.8 0.0 0.012 15.0 0.0 1.4 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit AAA_22 PF13401.6 ELR23891.1 - 0.0074 16.6 0.0 0.01 16.1 0.0 1.4 1 1 0 1 1 1 1 AAA domain AAA_24 PF13479.6 ELR23891.1 - 0.01 15.5 0.0 0.019 14.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 ELR23891.1 - 0.013 15.9 0.1 0.071 13.5 0.0 2.0 2 0 0 2 2 2 0 AAA ATPase domain cobW PF02492.19 ELR23891.1 - 0.013 15.1 0.2 0.065 12.8 0.1 2.0 1 1 1 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_7 PF12775.7 ELR23891.1 - 0.017 14.6 0.1 0.026 14.0 0.1 1.2 1 0 0 1 1 1 0 P-loop containing dynein motor region NTPase_1 PF03266.15 ELR23891.1 - 0.036 14.0 0.0 0.064 13.2 0.0 1.4 1 0 0 1 1 1 0 NTPase G-alpha PF00503.20 ELR23891.1 - 0.041 13.0 1.1 0.17 11.0 0.2 2.1 1 1 2 3 3 3 0 G-protein alpha subunit ATPase_2 PF01637.18 ELR23891.1 - 0.042 13.7 0.3 0.079 12.9 0.1 1.5 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea TniB PF05621.11 ELR23891.1 - 0.075 12.4 0.0 0.11 11.9 0.0 1.3 1 0 0 1 1 1 0 Bacterial TniB protein RNA_helicase PF00910.22 ELR23891.1 - 0.09 13.2 0.0 0.26 11.7 0.0 1.8 2 0 0 2 2 2 0 RNA helicase NB-ARC PF00931.22 ELR23891.1 - 0.097 11.8 0.3 0.14 11.3 0.1 1.4 2 0 0 2 2 2 0 NB-ARC domain NACHT PF05729.12 ELR23891.1 - 0.098 12.6 0.0 0.16 11.9 0.0 1.3 1 0 0 1 1 1 0 NACHT domain AAA_5 PF07728.14 ELR23891.1 - 0.14 12.1 0.0 0.31 11.0 0.0 1.6 1 1 1 2 2 2 0 AAA domain (dynein-related subfamily) ATP_bind_1 PF03029.17 ELR23891.1 - 0.15 11.8 1.1 37 4.0 0.0 2.9 2 1 1 3 3 3 0 Conserved hypothetical ATP binding protein NUDIX PF00293.28 ELR23892.1 - 7.1e-11 42.3 0.1 7.5e-11 42.2 0.1 1.0 1 0 0 1 1 1 1 NUDIX domain LPD7 PF18821.1 ELR23892.1 - 0.18 11.9 0.0 0.31 11.2 0.0 1.5 1 1 0 1 1 1 0 Large polyvalent protein-associated domain 7 LRR_4 PF12799.7 ELR23893.1 - 3.2e-05 24.2 10.1 0.024 15.1 3.6 2.7 1 1 0 2 2 2 2 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 ELR23893.1 - 9.1e-05 22.0 0.1 0.00017 21.1 0.1 1.3 1 0 0 1 1 1 1 Leucine-rich repeat LRR_8 PF13855.6 ELR23893.1 - 0.0014 18.4 8.6 0.044 13.6 3.4 3.0 1 1 2 3 3 3 2 Leucine rich repeat LRR_1 PF00560.33 ELR23893.1 - 4.1 8.3 6.8 46 5.1 0.1 3.9 2 1 0 2 2 2 0 Leucine Rich Repeat Prp18 PF02840.15 ELR23894.1 - 0.093 12.8 0.1 0.15 12.1 0.1 1.3 1 0 0 1 1 1 0 Prp18 domain HIT PF01230.23 ELR23896.1 - 5.1e-25 88.1 0.0 6.4e-25 87.8 0.0 1.1 1 0 0 1 1 1 1 HIT domain DcpS_C PF11969.8 ELR23896.1 - 1.2e-11 45.1 0.0 1.8e-11 44.6 0.0 1.3 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding CwfJ_C_1 PF04677.15 ELR23896.1 - 0.002 18.0 0.3 0.0039 17.1 0.3 1.5 1 1 0 1 1 1 1 Protein similar to CwfJ C-terminus 1 CBS PF00571.28 ELR23897.1 - 2.4e-21 75.9 0.1 7e-12 45.6 0.0 4.0 4 0 0 4 4 4 2 CBS domain YfkB PF08756.10 ELR23897.1 - 0.0042 16.9 0.0 0.074 12.8 0.0 2.2 2 0 0 2 2 2 1 YfkB-like domain Actin PF00022.19 ELR23898.1 - 5.9e-116 387.4 0.0 5.1e-115 384.3 0.0 1.9 1 1 0 1 1 1 1 Actin Arginase PF00491.21 ELR23900.1 - 1.2e-39 136.5 0.0 7e-39 134.0 0.0 1.8 1 1 0 1 1 1 1 Arginase family Ribosomal_L12 PF00542.19 ELR23901.1 - 8.6e-19 67.7 4.8 1.6e-18 66.8 4.8 1.5 1 0 0 1 1 1 1 Ribosomal protein L7/L12 C-terminal domain Ribosomal_60s PF00428.19 ELR23901.1 - 0.00015 22.3 12.9 0.00067 20.2 2.3 2.5 2 0 0 2 2 2 2 60s Acidic ribosomal protein Ribosomal_L12_N PF16320.5 ELR23901.1 - 0.00032 20.3 6.2 0.00032 20.3 6.2 3.6 3 1 0 3 3 3 1 Ribosomal protein L7/L12 dimerisation domain Abhydrolase_1 PF00561.20 ELR23902.1 - 6.4e-14 52.2 0.0 2.2e-10 40.6 0.0 2.2 1 1 1 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 ELR23902.1 - 2.6e-13 51.1 0.2 3.8e-13 50.6 0.2 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 ELR23902.1 - 3.5e-13 49.4 0.1 1.9e-10 40.4 0.1 2.2 1 1 1 2 2 2 2 Serine aminopeptidase, S33 Ser_hydrolase PF06821.13 ELR23902.1 - 2.1e-06 27.7 0.3 1.6e-05 24.8 0.0 2.4 3 0 0 3 3 3 1 Serine hydrolase Abhydrolase_3 PF07859.13 ELR23902.1 - 0.00015 21.7 0.0 0.00025 21.0 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold LIDHydrolase PF10230.9 ELR23902.1 - 0.0014 18.2 0.0 0.0039 16.8 0.0 1.7 1 1 1 2 2 2 1 Lipid-droplet associated hydrolase Abhydrolase_5 PF12695.7 ELR23902.1 - 0.0075 16.0 0.0 0.017 14.9 0.0 1.5 2 0 0 2 2 2 1 Alpha/beta hydrolase family BAAT_C PF08840.11 ELR23902.1 - 0.017 15.1 0.0 0.026 14.4 0.0 1.4 1 0 0 1 1 1 0 BAAT / Acyl-CoA thioester hydrolase C terminal DLH PF01738.18 ELR23902.1 - 0.024 14.2 0.0 0.039 13.5 0.0 1.3 1 0 0 1 1 1 0 Dienelactone hydrolase family Peptidase_S9 PF00326.21 ELR23902.1 - 0.025 14.0 0.0 0.065 12.7 0.0 1.6 1 1 0 1 1 1 0 Prolyl oligopeptidase family UPF0227 PF05728.12 ELR23902.1 - 0.028 14.4 0.0 0.052 13.5 0.0 1.4 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0227) PGAP1 PF07819.13 ELR23902.1 - 0.031 14.0 0.1 0.064 13.0 0.1 1.5 1 1 0 1 1 1 0 PGAP1-like protein DUF1673 PF07895.11 ELR23903.1 - 0.039 13.7 1.1 0.054 13.2 1.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1673) TPPK_C PF12555.8 ELR23903.1 - 0.12 12.4 4.1 0.16 12.0 0.1 2.4 2 1 0 2 2 2 0 Thiamine pyrophosphokinase C terminal RhoGAP PF00620.27 ELR23904.1 - 1.1e-21 77.2 0.0 2.9e-21 75.9 0.0 1.8 1 0 0 1 1 1 1 RhoGAP domain CTP_transf_like PF01467.26 ELR23905.1 - 3.4e-09 37.0 0.0 1.3e-08 35.1 0.0 1.9 1 1 0 1 1 1 1 Cytidylyltransferase-like Fer4_20 PF14691.6 ELR23906.1 - 0.43 10.4 11.1 3 7.6 3.8 2.7 2 1 0 2 2 2 0 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster Thioredoxin PF00085.20 ELR23907.1 - 2.4e-20 72.5 0.0 1.9e-19 69.6 0.0 2.1 2 0 0 2 2 2 1 Thioredoxin Thioredoxin_2 PF13098.6 ELR23907.1 - 3.8e-06 27.3 0.1 2.8e-05 24.5 0.0 2.2 2 1 0 2 2 2 1 Thioredoxin-like domain Thioredoxin_8 PF13905.6 ELR23907.1 - 3.8e-05 23.9 0.0 0.11 12.9 0.0 3.2 2 1 0 2 2 2 1 Thioredoxin-like OST3_OST6 PF04756.13 ELR23907.1 - 4.2e-05 23.0 0.0 0.00014 21.3 0.0 1.8 2 1 0 2 2 2 1 OST3 / OST6 family, transporter family Thioredoxin_6 PF13848.6 ELR23907.1 - 0.00055 19.9 0.0 0.0058 16.6 0.0 2.3 2 0 0 2 2 2 1 Thioredoxin-like domain Thioredoxin_4 PF13462.6 ELR23907.1 - 0.018 15.2 0.0 0.96 9.6 0.0 2.2 2 0 0 2 2 2 0 Thioredoxin Thioredoxin_7 PF13899.6 ELR23907.1 - 0.024 14.8 0.0 0.13 12.5 0.0 2.2 1 1 0 1 1 1 0 Thioredoxin-like DSBA PF01323.20 ELR23907.1 - 0.026 14.3 0.0 0.56 9.9 0.0 2.3 2 0 0 2 2 2 0 DSBA-like thioredoxin domain 5-FTHF_cyc-lig PF01812.20 ELR23908.1 - 5.8e-25 88.2 0.0 6.1e-25 88.2 0.0 1.0 1 0 0 1 1 1 1 5-formyltetrahydrofolate cyclo-ligase family JAB PF01398.21 ELR23909.1 - 1.6e-33 115.1 0.1 3.5e-33 114.1 0.1 1.6 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease CSN5_C PF18323.1 ELR23909.1 - 1.4e-26 93.2 0.3 2.8e-26 92.2 0.3 1.5 1 0 0 1 1 1 1 Cop9 signalosome subunit 5 C-terminal domain Prok-JAB PF14464.6 ELR23909.1 - 0.00076 19.2 0.0 0.0013 18.4 0.0 1.4 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain Vps52 PF04129.12 ELR23910.1 - 9.3e-126 420.5 14.6 1.3e-90 304.6 7.9 2.1 2 0 0 2 2 2 2 Vps52 / Sac2 family Sec3_C PF09763.9 ELR23910.1 - 1.2e-18 66.9 8.2 4.4e-13 48.5 5.9 2.2 2 0 0 2 2 2 2 Exocyst complex component Sec3 COG6 PF06419.11 ELR23910.1 - 6.7e-05 21.3 9.2 0.00027 19.3 0.5 2.6 2 0 0 2 2 2 2 Conserved oligomeric complex COG6 COG2 PF06148.11 ELR23910.1 - 0.022 14.9 3.9 0.094 12.8 3.9 2.1 1 0 0 1 1 1 0 COG (conserved oligomeric Golgi) complex component, COG2 CENP-F_leu_zip PF10473.9 ELR23910.1 - 0.07 13.1 5.0 0.18 11.8 5.0 1.7 1 0 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Syntaxin PF00804.25 ELR23910.1 - 0.28 10.8 5.3 4.9 6.8 0.9 2.7 1 1 1 2 2 2 0 Syntaxin DUF1664 PF07889.12 ELR23910.1 - 0.9 9.6 3.5 4.4 7.4 0.1 3.2 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) RhoGAP PF00620.27 ELR23911.1 - 2.5e-31 108.6 0.0 3e-31 108.3 0.0 1.0 1 0 0 1 1 1 1 RhoGAP domain RhoGAP PF00620.27 ELR23912.1 - 0.0065 16.3 1.0 0.028 14.3 0.1 2.2 2 0 0 2 2 2 1 RhoGAP domain VSG_B PF13206.6 ELR23912.1 - 0.17 11.1 7.9 0.23 10.7 7.9 1.1 1 0 0 1 1 1 0 Trypanosomal VSG domain DUF4763 PF15960.5 ELR23912.1 - 0.23 10.7 5.6 0.44 9.8 5.6 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4763) BUD22 PF09073.10 ELR23912.1 - 7.2 5.8 27.7 9.3 5.5 27.7 1.1 1 0 0 1 1 1 0 BUD22 Got1 PF04178.12 ELR23913.1 - 9.3e-32 109.8 17.0 1.6e-31 109.0 16.9 1.5 1 1 0 1 1 1 1 Got1/Sft2-like family YrhK PF14145.6 ELR23913.1 - 0.026 14.4 5.2 0.026 14.4 5.2 1.9 2 0 0 2 2 2 0 YrhK-like protein N-glycanase_C PF09113.10 ELR23914.1 - 6.3e-15 55.2 1.5 7.9e-14 51.6 0.7 2.8 2 1 0 2 2 2 1 Peptide-N-glycosidase F, C terminal PA PF02225.22 ELR23914.1 - 4.5e-10 39.4 0.0 9.5e-10 38.4 0.0 1.6 1 0 0 1 1 1 1 PA domain DUF1538 PF07556.11 ELR23915.1 - 3e-93 310.9 29.2 1.3e-54 184.7 8.3 3.0 2 1 0 2 2 2 2 Protein of unknown function (DUF1538) YL1 PF05764.13 ELR23915.1 - 0.0092 16.1 0.7 11 6.0 0.0 2.1 1 1 1 2 2 2 1 YL1 nuclear protein Drc1-Sld2 PF11719.8 ELR23915.1 - 2 7.9 3.6 3 7.3 3.6 1.1 1 0 0 1 1 1 0 DNA replication and checkpoint protein COesterase PF00135.28 ELR23916.1 - 1.1e-91 308.3 0.1 1.9e-90 304.2 0.1 2.0 1 1 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 ELR23916.1 - 9.5e-09 35.4 2.3 0.00022 21.1 0.1 2.3 2 0 0 2 2 2 2 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 ELR23916.1 - 0.0012 18.4 0.1 0.0021 17.5 0.1 1.4 1 0 0 1 1 1 1 Prolyl oligopeptidase family Esterase PF00756.20 ELR23916.1 - 0.01 15.5 0.2 0.025 14.2 0.2 1.6 1 1 0 1 1 1 0 Putative esterase LCAT PF02450.15 ELR23917.1 - 3.5e-86 289.8 0.5 1.1e-67 229.0 0.3 2.7 2 1 0 2 2 2 2 Lecithin:cholesterol acyltransferase Lipase_2 PF01674.18 ELR23917.1 - 0.00018 21.1 0.0 0.00036 20.1 0.0 1.4 1 0 0 1 1 1 1 Lipase (class 2) Hydrolase_4 PF12146.8 ELR23917.1 - 0.012 14.9 0.0 0.03 13.6 0.0 1.6 1 0 0 1 1 1 0 Serine aminopeptidase, S33 DUF900 PF05990.12 ELR23917.1 - 0.033 13.7 0.0 0.059 12.9 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF900) Pex19 PF04614.12 ELR23917.1 - 0.039 13.7 0.2 0.039 13.7 0.2 2.2 2 0 0 2 2 2 0 Pex19 protein family Macoilin PF09726.9 ELR23917.1 - 2.8 6.4 7.9 1.4 7.4 3.3 2.0 2 0 0 2 2 2 0 Macoilin family RR_TM4-6 PF06459.12 ELR23917.1 - 4.9 6.9 12.8 1.6 8.5 6.2 2.3 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 Apt1 PF10351.9 ELR23917.1 - 7.6 5.3 10.6 2.8 6.7 5.8 2.2 2 0 0 2 2 2 0 Golgi-body localisation protein domain Ribosomal_S5 PF00333.20 ELR23918.1 - 5.7e-09 35.8 1.7 5.7e-09 35.8 1.7 1.8 2 0 0 2 2 2 1 Ribosomal protein S5, N-terminal domain Ribosomal_S5_C PF03719.15 ELR23918.1 - 4.3e-08 32.5 0.0 9.5e-08 31.4 0.0 1.5 1 0 0 1 1 1 1 Ribosomal protein S5, C-terminal domain CDC45 PF02724.14 ELR23918.1 - 0.67 8.2 6.5 0.95 7.7 6.5 1.2 1 0 0 1 1 1 0 CDC45-like protein DNA_pol_phi PF04931.13 ELR23918.1 - 7.6 4.5 9.1 16 3.4 9.2 1.4 2 0 0 2 2 2 0 DNA polymerase phi BLOC1S3 PF15753.5 ELR23918.1 - 8.7 6.4 9.5 4.2 7.5 7.0 1.7 2 0 0 2 2 2 0 Biogenesis of lysosome-related organelles complex 1 subunit 3 DSPc PF00782.20 ELR23919.1 - 4.2e-10 39.5 0.0 0.00044 20.1 0.0 2.2 1 1 1 2 2 2 2 Dual specificity phosphatase, catalytic domain NUDIX PF00293.28 ELR23920.1 - 8.5e-15 54.9 0.0 1.2e-14 54.5 0.0 1.2 1 0 0 1 1 1 1 NUDIX domain Nudix_N_2 PF14803.6 ELR23920.1 - 2.3e-07 30.6 0.0 3.9e-07 29.9 0.0 1.4 1 0 0 1 1 1 1 Nudix N-terminal QWRF PF04484.12 ELR23922.1 - 8.3e-08 32.3 0.1 8.3e-08 32.3 0.1 3.0 1 1 1 2 2 2 1 QWRF family CENP-Q PF13094.6 ELR23922.1 - 0.0079 16.4 0.2 0.0079 16.4 0.2 3.3 3 1 0 3 3 3 1 CENP-Q, a CENPA-CAD centromere complex subunit DUF4551 PF15087.6 ELR23922.1 - 0.74 8.6 21.8 1 8.1 21.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) DUF1387 PF07139.11 ELR23922.1 - 5.8 6.6 19.5 11 5.7 18.7 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1387) SOG2 PF10428.9 ELR23922.1 - 9.1 5.3 46.9 16 4.5 46.9 1.3 1 1 0 1 1 1 0 RAM signalling pathway protein zf-Nse PF11789.8 ELR23923.1 - 5e-07 29.4 1.0 3.1e-06 26.9 1.0 2.1 1 1 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit OTU PF02338.19 ELR23925.1 - 1e-18 68.0 0.2 2.1e-18 67.0 0.1 1.5 2 0 0 2 2 2 1 OTU-like cysteine protease Peptidase_C65 PF10275.9 ELR23925.1 - 5.9e-05 22.6 2.1 0.078 12.4 0.1 2.2 2 0 0 2 2 2 2 Peptidase C65 Otubain TetR_C_11 PF16859.5 ELR23925.1 - 0.011 16.0 0.2 0.097 13.0 0.0 2.2 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain UPF0561 PF10573.9 ELR23925.1 - 0.047 13.8 0.1 0.091 12.9 0.1 1.5 1 0 0 1 1 1 0 Uncharacterised protein family UPF0561 CH PF00307.31 ELR23926.1 - 1.4e-37 128.2 0.0 3.3e-19 69.1 0.0 2.1 2 0 0 2 2 2 2 Calponin homology (CH) domain CAMSAP_CH PF11971.8 ELR23926.1 - 1.7e-08 34.2 0.0 0.001 18.9 0.0 2.4 2 0 0 2 2 2 2 CAMSAP CH domain CH_2 PF06294.11 ELR23926.1 - 0.00092 19.3 0.0 0.15 12.2 0.0 2.4 2 0 0 2 2 2 2 CH-like domain in sperm protein DUF2046 PF09755.9 ELR23927.1 - 0.0012 18.1 3.1 0.0019 17.5 3.1 1.2 1 0 0 1 1 1 1 Uncharacterized conserved protein H4 (DUF2046) Cep57_CLD_2 PF14197.6 ELR23927.1 - 0.025 14.7 5.9 0.25 11.5 4.2 2.5 2 0 0 2 2 2 0 Centrosome localisation domain of PPC89 FIBP PF05427.11 ELR23927.1 - 0.031 13.6 0.2 0.035 13.4 0.2 1.1 1 0 0 1 1 1 0 Acidic fibroblast growth factor binding (FIBP) COG5 PF10392.9 ELR23927.1 - 0.033 14.3 1.7 0.046 13.9 1.7 1.2 1 0 0 1 1 1 0 Golgi transport complex subunit 5 JAKMIP_CC3 PF16034.5 ELR23927.1 - 0.061 13.3 8.0 0.11 12.4 8.0 1.5 1 1 0 1 1 1 0 JAKMIP CC3 domain Mac-1 PF09028.10 ELR23927.1 - 0.11 11.6 0.1 0.13 11.3 0.1 1.1 1 0 0 1 1 1 0 Mac 1 HrpB7 PF09486.10 ELR23927.1 - 0.13 12.6 10.6 0.78 10.1 10.6 2.1 1 1 0 1 1 1 0 Bacterial type III secretion protein (HrpB7) UPF0242 PF06785.11 ELR23927.1 - 0.34 11.0 10.4 0.46 10.6 10.4 1.3 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus ATG16 PF08614.11 ELR23927.1 - 0.81 9.9 13.7 0.98 9.6 13.7 1.1 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) DUF812 PF05667.11 ELR23927.1 - 1.6 7.5 11.9 2.1 7.2 11.9 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF812) Lebercilin PF15619.6 ELR23927.1 - 1.9 8.1 13.5 2.6 7.7 13.5 1.2 1 0 0 1 1 1 0 Ciliary protein causing Leber congenital amaurosis disease YabA PF06156.13 ELR23927.1 - 2 9.1 6.6 9.4 6.9 5.7 2.3 1 1 0 1 1 1 0 Initiation control protein YabA Golgin_A5 PF09787.9 ELR23927.1 - 2.4 7.5 11.0 5.5 6.4 10.6 1.7 1 1 0 1 1 1 0 Golgin subfamily A member 5 Jnk-SapK_ap_N PF09744.9 ELR23927.1 - 2.6 8.2 13.3 0.047 13.9 6.6 1.5 2 0 0 2 2 2 0 JNK_SAPK-associated protein-1 ZapB PF06005.12 ELR23927.1 - 3.8 8.0 14.6 1.6 9.2 6.9 2.9 2 2 0 2 2 2 0 Cell division protein ZapB DUF3347 PF11827.8 ELR23927.1 - 3.8 7.6 9.0 6.1 7.0 9.0 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF3347) SlyX PF04102.12 ELR23927.1 - 7.5 7.2 9.0 0.71 10.5 1.6 2.4 2 1 1 3 3 2 0 SlyX eIF3_subunit PF08597.10 ELR23928.1 - 2e-38 132.7 26.2 2.4e-38 132.4 26.2 1.1 1 0 0 1 1 1 1 Translation initiation factor eIF3 subunit TPR_1 PF00515.28 ELR23929.1 - 4.7e-38 127.5 12.7 1.9e-07 30.6 0.2 6.2 5 1 1 6 6 6 6 Tetratricopeptide repeat TPR_2 PF07719.17 ELR23929.1 - 7.9e-31 103.7 15.7 1.1e-05 25.1 0.5 6.3 5 1 1 6 6 6 6 Tetratricopeptide repeat TPR_11 PF13414.6 ELR23929.1 - 1.7e-19 69.2 9.2 8.5e-10 38.2 0.1 5.4 4 1 1 5 5 5 4 TPR repeat TPR_8 PF13181.6 ELR23929.1 - 7.6e-19 66.3 11.4 8.5e-05 22.5 0.3 6.3 5 1 1 6 6 6 3 Tetratricopeptide repeat TPR_16 PF13432.6 ELR23929.1 - 5.6e-12 46.1 15.3 0.0034 18.0 0.1 5.1 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_9 PF13371.6 ELR23929.1 - 6e-12 45.5 1.7 0.001 19.2 0.2 3.7 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_7 PF13176.6 ELR23929.1 - 1.3e-08 34.2 4.5 0.21 11.7 0.1 4.8 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_12 PF13424.6 ELR23929.1 - 2.5e-08 34.1 13.9 0.0062 16.8 2.3 5.2 2 2 2 5 5 5 4 Tetratricopeptide repeat TPR_14 PF13428.6 ELR23929.1 - 3.4e-08 33.6 8.6 0.26 12.2 0.1 5.0 3 1 2 5 5 5 3 Tetratricopeptide repeat TPR_17 PF13431.6 ELR23929.1 - 7.8e-08 32.2 6.3 0.069 13.6 0.1 6.2 6 1 0 6 6 6 2 Tetratricopeptide repeat ANAPC3 PF12895.7 ELR23929.1 - 2.4e-06 27.7 12.1 0.00028 21.1 0.3 3.4 2 1 1 3 3 3 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.6 ELR23929.1 - 2.6e-06 27.8 5.1 0.018 15.6 0.0 4.3 2 1 2 4 4 4 1 Tetratricopeptide repeat DUF3856 PF12968.7 ELR23929.1 - 9.1e-05 22.6 8.3 0.19 11.8 0.7 3.9 2 2 1 3 3 3 2 Domain of Unknown Function (DUF3856) SHNi-TPR PF10516.9 ELR23929.1 - 0.00017 20.9 0.0 15 5.1 0.0 5.6 7 0 0 7 7 7 0 SHNi-TPR DUF3808 PF10300.9 ELR23929.1 - 0.00022 20.1 3.8 0.043 12.6 0.4 2.1 2 0 0 2 2 2 2 Protein of unknown function (DUF3808) MIT PF04212.18 ELR23929.1 - 0.00029 20.9 12.6 0.56 10.3 0.1 4.9 4 1 0 4 4 4 2 MIT (microtubule interacting and transport) domain SRP_TPR_like PF17004.5 ELR23929.1 - 0.00078 19.5 6.7 0.61 10.1 2.3 3.3 1 1 2 3 3 3 2 Putative TPR-like repeat TPR_6 PF13174.6 ELR23929.1 - 0.01 16.4 13.2 1.6 9.5 0.2 5.4 6 0 0 6 6 5 0 Tetratricopeptide repeat TPR_3 PF07720.12 ELR23929.1 - 0.27 11.3 2.5 2.1 8.5 0.1 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat CSN5_C PF18323.1 ELR23929.1 - 0.28 12.1 1.6 0.47 11.4 1.0 1.6 1 1 0 1 1 1 0 Cop9 signalosome subunit 5 C-terminal domain Sel1 PF08238.12 ELR23929.1 - 0.51 11.1 3.4 1 10.1 0.6 3.0 2 0 0 2 2 2 0 Sel1 repeat DUF3560 PF12083.8 ELR23929.1 - 1.8 8.7 11.4 1.2 9.3 0.4 3.3 3 1 0 3 3 3 0 Domain of unknown function (DUF3560) RabGAP-TBC PF00566.18 ELR23930.1 - 5.4e-18 65.4 2.0 5.3e-16 58.9 0.5 2.2 2 0 0 2 2 2 2 Rab-GTPase-TBC domain Pkinase PF00069.25 ELR23931.1 - 3.9e-65 219.8 0.0 5e-65 219.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR23931.1 - 2.1e-38 132.1 0.0 2.8e-38 131.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ELR23931.1 - 2.7e-06 26.9 0.0 5.3e-06 26.0 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 ELR23931.1 - 0.00013 21.3 0.1 0.00027 20.4 0.1 1.5 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 ELR23931.1 - 0.00015 21.7 0.4 0.2 11.5 0.0 2.2 1 1 1 2 2 2 2 Phosphotransferase enzyme family Haspin_kinase PF12330.8 ELR23931.1 - 0.00044 19.3 0.1 0.00044 19.3 0.1 1.6 2 0 0 2 2 2 1 Haspin like kinase domain Choline_kinase PF01633.20 ELR23931.1 - 0.11 12.1 0.2 0.43 10.1 0.2 1.8 1 1 0 1 1 1 0 Choline/ethanolamine kinase UCR_6-4kD PF08997.10 ELR23932.1 - 0.079 12.9 0.0 0.13 12.3 0.0 1.4 1 0 0 1 1 1 0 Ubiquinol-cytochrome C reductase complex, 6.4kD protein Ras PF00071.22 ELR23933.1 - 1.6e-40 138.4 0.0 1.9e-40 138.1 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR23933.1 - 2.2e-17 63.4 0.1 4.4e-17 62.4 0.0 1.6 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR23933.1 - 2.9e-08 33.4 0.0 3.6e-08 33.0 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 ELR23933.1 - 0.014 14.7 0.0 0.017 14.5 0.0 1.2 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region Exonuc_X-T_C PF08411.10 ELR23933.1 - 0.018 14.2 0.4 0.025 13.7 0.4 1.2 1 0 0 1 1 1 0 Exonuclease C-terminal Ras PF00071.22 ELR23934.1 - 9.8e-37 126.0 0.0 1.2e-36 125.7 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR23934.1 - 2.4e-15 56.8 0.0 4.1e-15 56.1 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR23934.1 - 2e-11 43.7 0.0 2.6e-11 43.3 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 ELR23934.1 - 0.006 16.1 0.0 0.011 15.3 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 ELR23934.1 - 0.02 14.3 0.0 0.026 13.9 0.0 1.2 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region Peptidase_S28 PF05577.12 ELR23935.1 - 4e-131 437.8 0.0 4.6e-131 437.6 0.0 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase S28 Hydrolase_4 PF12146.8 ELR23935.1 - 0.089 12.0 0.0 0.14 11.4 0.0 1.3 1 0 0 1 1 1 0 Serine aminopeptidase, S33 RhoGEF PF00621.20 ELR23936.1 - 8.7e-38 130.4 1.8 1.6e-37 129.5 1.8 1.4 1 0 0 1 1 1 1 RhoGEF domain CH PF00307.31 ELR23936.1 - 3.9e-09 36.7 0.0 1.5e-08 34.8 0.0 2.0 2 0 0 2 2 2 1 Calponin homology (CH) domain PH PF00169.29 ELR23936.1 - 1.1e-05 25.9 0.2 3e-05 24.5 0.1 1.9 2 0 0 2 2 2 1 PH domain PH_13 PF16652.5 ELR23936.1 - 0.00066 19.5 1.2 0.001 18.9 0.3 1.8 2 0 0 2 2 2 1 Pleckstrin homology domain IQ_SEC7_PH PF16453.5 ELR23936.1 - 0.0015 18.6 0.0 0.0041 17.1 0.0 1.8 1 0 0 1 1 1 1 PH domain IQ PF00612.27 ELR23936.1 - 0.11 12.4 1.1 0.19 11.6 0.3 1.9 2 0 0 2 2 2 0 IQ calmodulin-binding motif Ntox10 PF15520.6 ELR23936.1 - 0.11 12.3 0.1 0.23 11.3 0.1 1.4 1 0 0 1 1 1 0 Novel toxin 10 Coatomer_WDAD PF04053.14 ELR23937.1 - 1.8e-08 33.9 0.0 2.3e-07 30.2 0.0 2.2 1 1 0 1 1 1 1 Coatomer WD associated region WD40 PF00400.32 ELR23937.1 - 2.6e-05 24.9 0.0 0.0031 18.3 0.0 3.7 3 0 0 3 3 3 1 WD domain, G-beta repeat Nucleoporin_N PF08801.11 ELR23937.1 - 0.034 12.9 0.1 0.14 10.9 0.0 2.0 3 0 0 3 3 3 0 Nup133 N terminal like TMEM239 PF15841.5 ELR23937.1 - 0.06 13.2 0.4 0.14 12.1 0.4 1.5 1 0 0 1 1 1 0 Transmembrane protein 239 family Hira PF07569.11 ELR23937.1 - 0.19 11.4 0.1 41 3.8 0.0 3.1 1 1 2 3 3 3 0 TUP1-like enhancer of split RRM_1 PF00076.22 ELR23938.1 - 8.2e-24 83.2 0.0 1.1e-23 82.8 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 ELR23938.1 - 0.0006 19.8 0.1 0.00097 19.1 0.1 1.4 1 1 0 1 1 1 1 RNA binding motif RRM_7 PF16367.5 ELR23938.1 - 0.0015 18.6 0.0 0.0029 17.7 0.0 1.5 1 1 0 1 1 1 1 RNA recognition motif PHM7_cyt PF14703.6 ELR23938.1 - 0.075 13.3 0.0 0.13 12.4 0.0 1.4 1 1 0 1 1 1 0 Cytosolic domain of 10TM putative phosphate transporter N-SET PF11764.8 ELR23938.1 - 0.16 12.1 0.0 0.24 11.5 0.0 1.3 1 0 0 1 1 1 0 COMPASS (Complex proteins associated with Set1p) component N SDA1 PF05285.12 ELR23939.1 - 0.025 14.0 9.1 0.034 13.6 9.1 1.2 1 0 0 1 1 1 0 SDA1 COPI_C PF06957.11 ELR23939.1 - 0.076 11.8 0.0 0.076 11.8 0.0 3.3 4 0 0 4 4 4 0 Coatomer (COPI) alpha subunit C-terminus CDC45 PF02724.14 ELR23939.1 - 0.15 10.3 4.6 0.18 10.1 4.6 1.1 1 0 0 1 1 1 0 CDC45-like protein HypA PF01155.19 ELR23939.1 - 7.2 6.7 6.1 5.5 7.0 0.2 2.3 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Glycos_transf_2 PF00535.26 ELR23940.1 - 3.4e-30 105.1 0.0 2e-29 102.6 0.0 1.9 1 1 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 ELR23940.1 - 2.6e-12 47.1 0.0 6.1e-11 42.6 0.0 2.0 1 1 1 2 2 2 1 Glycosyltransferase like family 2 Glyco_transf_21 PF13506.6 ELR23940.1 - 0.00074 19.0 0.0 0.0019 17.7 0.0 1.7 1 1 0 1 1 1 1 Glycosyl transferase family 21 Glyco_tranf_2_2 PF10111.9 ELR23940.1 - 0.0052 16.3 0.0 0.0071 15.9 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 PhyH PF05721.13 ELR23941.1 - 4.9e-07 30.2 0.2 4.9e-07 30.2 0.2 1.6 2 0 0 2 2 2 1 Phytanoyl-CoA dioxygenase (PhyH) Usp PF00582.26 ELR23942.1 - 7.8e-09 36.2 0.5 2.3e-05 24.9 0.3 2.2 1 1 1 2 2 2 2 Universal stress protein family LRR_4 PF12799.7 ELR23943.1 - 0.0047 17.3 12.0 0.2 12.1 0.0 6.6 4 1 3 8 8 8 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 ELR23943.1 - 0.017 14.9 7.1 0.6 9.9 0.4 5.6 4 1 0 4 4 4 0 Leucine rich repeat LRR_6 PF13516.6 ELR23943.1 - 0.031 14.3 15.1 0.41 10.8 0.0 7.0 8 0 0 8 8 8 0 Leucine Rich repeat GST_C PF00043.25 ELR23944.1 - 2.1e-12 47.1 0.0 3.6e-12 46.3 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 ELR23944.1 - 3.9e-12 46.3 0.0 5.9e-12 45.8 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 ELR23944.1 - 4.2e-11 43.0 0.0 7.1e-11 42.3 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 ELR23944.1 - 2.1e-10 40.9 0.0 4e-10 40.0 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 ELR23944.1 - 4.7e-10 39.5 0.0 9.2e-10 38.6 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 ELR23944.1 - 1.8e-06 27.9 0.1 3.1e-06 27.1 0.1 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Usp PF00582.26 ELR23945.1 - 1e-10 42.3 0.0 5.4e-10 39.9 0.0 1.9 1 1 0 1 1 1 1 Universal stress protein family Zn_clus PF00172.18 ELR23946.1 - 1.8e-05 24.7 15.8 3.6e-05 23.8 15.8 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain ING PF12998.7 ELR23946.1 - 0.032 14.8 0.2 0.082 13.5 0.2 1.6 1 0 0 1 1 1 0 Inhibitor of growth proteins N-terminal histone-binding ANAPC4 PF12896.7 ELR23946.1 - 0.092 12.2 0.0 0.15 11.5 0.0 1.3 1 0 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 4 NPR2 PF06218.11 ELR23946.1 - 0.24 10.1 0.6 0.56 8.9 0.0 1.7 2 0 0 2 2 2 0 Nitrogen permease regulator 2 RRM_1 PF00076.22 ELR23947.1 - 2.2e-15 56.2 0.0 3e-15 55.8 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-CCHC PF00098.23 ELR23947.1 - 3.8e-08 33.0 10.5 4.1e-07 29.8 3.3 2.4 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_5 PF14787.6 ELR23947.1 - 0.00014 21.4 3.9 0.00014 21.4 3.9 2.1 3 0 0 3 3 3 1 GAG-polyprotein viral zinc-finger RRM_5 PF13893.6 ELR23947.1 - 0.0014 18.2 0.0 0.0021 17.7 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-CCHC_2 PF13696.6 ELR23947.1 - 0.0015 18.3 1.2 0.0027 17.5 1.2 1.4 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_3 PF13917.6 ELR23947.1 - 0.021 14.8 0.3 0.021 14.8 0.3 2.3 3 0 0 3 3 3 0 Zinc knuckle HypA PF01155.19 ELR23947.1 - 0.12 12.4 0.0 0.16 12.0 0.0 1.3 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Limkain-b1 PF11608.8 ELR23947.1 - 0.16 12.1 0.0 0.25 11.4 0.0 1.3 1 0 0 1 1 1 0 Limkain b1 RRM_1 PF00076.22 ELR23948.1 - 2.6e-18 65.6 0.0 3.7e-18 65.1 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 ELR23948.1 - 7.1e-06 25.6 0.0 1.1e-05 25.1 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RL PF17797.1 ELR23948.1 - 0.0049 16.8 0.0 0.0094 15.9 0.0 1.4 1 0 0 1 1 1 1 RL domain DKCLD PF08068.12 ELR23950.1 - 2e-33 114.2 0.6 2.9e-32 110.5 0.6 2.4 2 0 0 2 2 2 1 DKCLD (NUC011) domain TruB_N PF01509.18 ELR23950.1 - 2.8e-22 79.7 0.3 2.4e-19 70.2 0.3 3.5 1 1 0 1 1 1 1 TruB family pseudouridylate synthase (N terminal domain) PUA PF01472.20 ELR23950.1 - 1.1e-20 73.4 2.0 1.1e-20 73.4 2.0 2.0 2 0 0 2 2 2 1 PUA domain TruB_C_2 PF16198.5 ELR23950.1 - 1.9e-19 69.6 0.7 4.6e-19 68.3 0.7 1.7 1 0 0 1 1 1 1 tRNA pseudouridylate synthase B C-terminal domain UPF0113 PF03657.13 ELR23950.1 - 0.0022 18.2 0.0 0.0057 16.9 0.0 1.7 1 0 0 1 1 1 1 UPF0113 PUA domain LicD PF04991.13 ELR23950.1 - 0.22 11.6 8.6 0.36 10.9 8.6 1.3 1 0 0 1 1 1 0 LicD family SR-25 PF10500.9 ELR23950.1 - 1.7 8.2 39.2 0.34 10.5 35.2 1.8 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein SAPS PF04499.15 ELR23950.1 - 1.9 7.2 8.6 2.4 6.8 8.6 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein RR_TM4-6 PF06459.12 ELR23950.1 - 3.5 7.4 18.5 5.3 6.8 18.5 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Sec1 PF00995.23 ELR23951.1 - 2.6e-16 60.0 0.0 2.3e-07 30.4 0.0 2.1 2 0 0 2 2 2 2 Sec1 family UQ_con PF00179.26 ELR23953.1 - 8.8e-51 171.2 0.0 9.9e-51 171.1 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 ELR23953.1 - 0.0052 16.5 0.0 0.0066 16.1 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.22 ELR23953.1 - 0.014 15.6 0.0 0.015 15.6 0.0 1.3 1 0 0 1 1 1 0 RWD domain UEV PF05743.13 ELR23953.1 - 0.11 12.4 0.3 0.19 11.6 0.3 1.4 1 1 0 1 1 1 0 UEV domain YqaJ PF09588.10 ELR23956.1 - 1.3e-14 54.6 0.1 2e-14 54.0 0.1 1.1 1 0 0 1 1 1 1 YqaJ-like viral recombinase domain DAP_epimerase PF01678.19 ELR23957.1 - 5.2e-39 133.2 0.0 1.3e-19 70.5 0.0 3.5 3 1 0 3 3 3 3 Diaminopimelate epimerase Amino_oxidase PF01593.24 ELR23958.1 - 4.5e-63 214.1 0.0 5.6e-63 213.8 0.0 1.1 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 ELR23958.1 - 1e-12 48.1 0.1 2.3e-12 47.0 0.1 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 ELR23958.1 - 8.5e-06 25.6 0.2 0.017 14.8 0.1 2.1 2 0 0 2 2 2 2 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 ELR23958.1 - 1.6e-05 24.2 0.5 2.9e-05 23.3 0.5 1.4 1 0 0 1 1 1 1 FAD binding domain FAD_binding_3 PF01494.19 ELR23958.1 - 4.1e-05 23.0 1.0 5.5e-05 22.6 0.3 1.6 2 0 0 2 2 2 1 FAD binding domain Pyr_redox_2 PF07992.14 ELR23958.1 - 6.6e-05 22.3 0.8 0.00022 20.6 0.3 1.9 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 ELR23958.1 - 0.0002 20.2 0.1 0.023 13.4 0.1 2.2 2 0 0 2 2 2 1 HI0933-like protein Lycopene_cycl PF05834.12 ELR23958.1 - 0.00066 18.8 0.6 0.005 15.9 0.2 2.1 2 0 0 2 2 2 1 Lycopene cyclase protein FAD_oxidored PF12831.7 ELR23958.1 - 0.00066 19.1 0.2 0.00093 18.6 0.2 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase Thi4 PF01946.17 ELR23958.1 - 0.00092 18.5 0.1 0.0014 17.9 0.1 1.2 1 0 0 1 1 1 1 Thi4 family NAD_binding_9 PF13454.6 ELR23958.1 - 0.034 14.1 1.9 1.8 8.5 0.1 2.8 3 0 0 3 3 3 0 FAD-NAD(P)-binding Hfx_Cass5 PF18287.1 ELR23958.1 - 0.067 13.4 0.0 0.14 12.3 0.0 1.6 1 0 0 1 1 1 0 Integron Cassette Protein Hfx_Cass5 GIDA PF01134.22 ELR23958.1 - 0.081 12.0 0.2 0.61 9.1 0.2 2.0 2 0 0 2 2 2 0 Glucose inhibited division protein A 3HCDH_N PF02737.18 ELR23958.1 - 0.087 12.7 0.1 0.16 11.9 0.1 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain FMO-like PF00743.19 ELR23958.1 - 0.098 11.1 0.0 0.13 10.6 0.0 1.1 1 0 0 1 1 1 0 Flavin-binding monooxygenase-like GDI PF00996.18 ELR23958.1 - 0.12 10.9 0.1 0.18 10.3 0.1 1.2 1 0 0 1 1 1 0 GDP dissociation inhibitor Pyr_redox_3 PF13738.6 ELR23958.1 - 0.13 11.5 0.7 3.7 6.7 0.1 2.1 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase ENOD93 PF03386.14 ELR23959.1 - 0.0034 17.2 0.0 0.0045 16.8 0.0 1.2 1 0 0 1 1 1 1 Early nodulin 93 ENOD93 protein Yip1 PF04893.17 ELR23960.1 - 1e-08 35.1 18.8 2.2e-08 34.0 18.8 1.6 1 1 0 1 1 1 1 Yip1 domain DUF3925 PF13063.6 ELR23960.1 - 0.18 12.0 0.1 0.18 12.0 0.1 2.4 3 0 0 3 3 3 0 Protein of unknown function (DUF3925) BTB_2 PF02214.22 ELR23961.1 - 6.2e-12 45.7 0.0 8.6e-12 45.3 0.0 1.3 1 0 0 1 1 1 1 BTB/POZ domain T2SSM PF04612.12 ELR23961.1 - 0.026 14.6 4.5 0.25 11.4 4.4 2.2 1 1 0 1 1 1 0 Type II secretion system (T2SS), protein M DUF4407 PF14362.6 ELR23961.1 - 0.041 13.2 5.4 0.048 13.0 5.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DegT_DnrJ_EryC1 PF01041.17 ELR23961.1 - 0.072 12.4 0.8 0.1 11.9 0.8 1.3 1 0 0 1 1 1 0 DegT/DnrJ/EryC1/StrS aminotransferase family Phage_GPO PF05929.11 ELR23961.1 - 0.28 10.8 4.4 0.39 10.3 4.4 1.2 1 0 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase ADIP PF11559.8 ELR23961.1 - 0.29 11.2 6.1 0.41 10.7 6.1 1.2 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding SlyX PF04102.12 ELR23961.1 - 0.47 11.1 7.0 1.1 10.0 7.0 1.6 1 0 0 1 1 1 0 SlyX DUF3138 PF11336.8 ELR23961.1 - 0.64 8.6 2.1 0.71 8.4 2.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) APG6_N PF17675.1 ELR23961.1 - 0.78 10.3 9.7 1.3 9.5 9.7 1.3 1 0 0 1 1 1 0 Apg6 coiled-coil region Atg14 PF10186.9 ELR23961.1 - 1.2 8.2 3.4 1.6 7.8 3.4 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 HemX PF04375.14 ELR23961.1 - 1.3 8.2 10.1 1.8 7.8 10.1 1.4 1 1 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase PEP-utilisers_N PF05524.13 ELR23961.1 - 1.5 9.1 8.4 1.3 9.2 7.0 1.6 1 1 1 2 2 2 0 PEP-utilising enzyme, N-terminal DUF349 PF03993.12 ELR23961.1 - 8.6 6.7 12.2 7.5 6.9 7.0 2.2 1 1 1 2 2 2 0 Domain of Unknown Function (DUF349) RseA_C PF03873.13 ELR23961.1 - 8.7 6.7 8.1 18 5.7 1.6 3.3 3 1 1 4 4 4 0 Anti sigma-E protein RseA, C-terminal domain Pkinase_Tyr PF07714.17 ELR23963.1 - 6.5e-127 422.2 0.0 5.9e-63 212.5 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 ELR23963.1 - 7.1e-110 366.5 0.0 6.7e-56 189.6 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Guanylate_cyc PF00211.20 ELR23963.1 - 1.5e-13 50.8 0.0 2.6e-13 50.0 0.0 1.3 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain APH PF01636.23 ELR23963.1 - 3.6e-06 27.1 3.3 0.0022 18.0 0.1 3.6 2 2 1 4 4 4 2 Phosphotransferase enzyme family Kinase-like PF14531.6 ELR23963.1 - 1.2e-05 24.8 0.2 0.0089 15.4 0.0 2.5 3 0 0 3 3 3 2 Kinase-like Haspin_kinase PF12330.8 ELR23963.1 - 7.5e-05 21.8 0.1 0.011 14.7 0.0 2.2 2 0 0 2 2 2 2 Haspin like kinase domain RIO1 PF01163.22 ELR23963.1 - 0.00013 21.6 0.6 0.41 10.2 0.1 2.3 2 0 0 2 2 2 2 RIO1 family Kdo PF06293.14 ELR23963.1 - 0.00089 18.7 0.5 1.1 8.6 0.2 2.4 2 0 0 2 2 2 2 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 ELR23963.1 - 0.0012 17.7 0.0 0.34 9.6 0.0 2.2 2 0 0 2 2 2 2 Fungal protein kinase FTA2 PF13095.6 ELR23963.1 - 0.005 16.5 0.0 0.28 10.8 0.0 3.1 3 1 1 4 4 4 1 Kinetochore Sim4 complex subunit FTA2 TMEM154 PF15102.6 ELR23963.1 - 0.0052 16.7 0.0 0.011 15.7 0.0 1.4 1 0 0 1 1 1 1 TMEM154 protein family EGF_2 PF07974.13 ELR23963.1 - 0.026 14.9 8.9 0.053 13.9 8.9 1.6 1 0 0 1 1 1 0 EGF-like domain Seadorna_VP7 PF07387.11 ELR23963.1 - 0.088 11.8 0.2 0.34 9.9 0.0 1.8 2 0 0 2 2 2 0 Seadornavirus VP7 EGF_Tenascin PF18720.1 ELR23963.1 - 0.15 12.1 5.7 0.32 11.1 5.7 1.6 1 0 0 1 1 1 0 Tenascin EGF domain RhoGEF PF00621.20 ELR23964.1 - 1.7e-46 158.8 0.1 4.8e-46 157.3 0.1 1.8 1 0 0 1 1 1 1 RhoGEF domain PH PF00169.29 ELR23964.1 - 0.0003 21.3 0.2 0.0016 18.9 0.2 2.2 1 1 0 1 1 1 1 PH domain PH_13 PF16652.5 ELR23964.1 - 0.058 13.2 0.6 0.94 9.3 0.0 2.8 2 0 0 2 2 2 0 Pleckstrin homology domain CENP-B_dimeris PF09026.10 ELR23964.1 - 0.19 12.1 9.0 0.73 10.3 9.0 2.0 1 0 0 1 1 1 0 Centromere protein B dimerisation domain V_ATPase_I PF01496.19 ELR23964.1 - 3.2 5.6 6.2 4.1 5.2 2.8 2.1 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family AAA PF00004.29 ELR23967.1 - 2.8e-46 157.2 0.1 3e-24 85.9 0.0 2.4 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) Zot PF05707.12 ELR23967.1 - 1e-06 28.5 1.5 0.033 13.8 0.3 3.7 2 2 2 4 4 4 2 Zonular occludens toxin (Zot) AAA_22 PF13401.6 ELR23967.1 - 1.2e-06 28.8 1.6 0.0031 17.8 0.0 3.9 3 1 0 4 4 3 1 AAA domain AAA_lid_3 PF17862.1 ELR23967.1 - 3.8e-05 23.4 1.2 0.0026 17.5 0.6 2.7 2 0 0 2 2 2 1 AAA+ lid domain AAA_16 PF13191.6 ELR23967.1 - 0.00025 21.5 0.0 0.19 12.1 0.0 2.7 2 0 0 2 2 2 1 AAA ATPase domain RNA_helicase PF00910.22 ELR23967.1 - 0.00046 20.6 0.1 0.042 14.3 0.0 2.6 2 0 0 2 2 2 1 RNA helicase IstB_IS21 PF01695.17 ELR23967.1 - 0.00049 19.9 0.0 0.11 12.3 0.0 2.5 2 0 0 2 2 2 1 IstB-like ATP binding protein AAA_7 PF12775.7 ELR23967.1 - 0.00051 19.6 0.2 0.058 12.9 0.1 2.4 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_18 PF13238.6 ELR23967.1 - 0.00072 20.1 0.0 0.21 12.2 0.0 2.7 2 0 0 2 2 2 1 AAA domain RuvB_N PF05496.12 ELR23967.1 - 0.00088 19.0 0.0 1.1 8.9 0.0 2.5 2 0 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_33 PF13671.6 ELR23967.1 - 0.0018 18.5 0.0 2.7 8.2 0.0 2.6 2 0 0 2 2 2 2 AAA domain Sigma54_activat PF00158.26 ELR23967.1 - 0.0018 18.0 0.2 2.6 7.7 0.0 2.5 2 0 0 2 2 2 2 Sigma-54 interaction domain AAA_24 PF13479.6 ELR23967.1 - 0.0022 17.8 0.1 0.1 12.3 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_5 PF07728.14 ELR23967.1 - 0.0069 16.4 0.0 0.87 9.6 0.0 2.7 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.21 ELR23967.1 - 0.011 15.2 0.7 0.48 9.8 0.2 2.4 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_25 PF13481.6 ELR23967.1 - 0.024 14.2 1.2 6.5 6.3 0.2 2.6 2 0 0 2 2 2 0 AAA domain TIP49 PF06068.13 ELR23967.1 - 0.041 13.1 0.1 0.56 9.4 0.0 2.2 2 0 0 2 2 2 0 TIP49 P-loop domain PEPCK_ATP PF01293.20 ELR23967.1 - 0.058 12.1 1.3 5.2 5.6 0.0 2.2 2 0 0 2 2 2 0 Phosphoenolpyruvate carboxykinase AAA_6 PF12774.7 ELR23967.1 - 0.11 11.4 0.2 2.4 7.0 0.0 2.4 2 0 0 2 2 2 0 Hydrolytic ATP binding site of dynein motor region AAA_3 PF07726.11 ELR23967.1 - 0.12 12.2 0.0 7.3 6.5 0.0 2.5 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_2 PF07724.14 ELR23967.1 - 0.14 12.3 0.1 5.6 7.0 0.0 2.8 2 1 0 2 2 2 0 AAA domain (Cdc48 subfamily) AAA_30 PF13604.6 ELR23967.1 - 0.21 11.3 0.1 26 4.5 0.0 2.4 2 0 0 2 2 2 0 AAA domain Use1 PF09753.9 ELR23968.1 - 0.071 12.8 0.0 0.1 12.3 0.0 1.3 1 1 0 1 1 1 0 Membrane fusion protein Use1 Nanovirus_coat PF04660.12 ELR23968.1 - 0.13 12.3 0.0 0.17 11.9 0.0 1.1 1 0 0 1 1 1 0 Nanovirus coat protein F_actin_bund_C PF18060.1 ELR23969.1 - 1.4e-17 63.6 17.7 1.4e-17 63.6 17.7 3.9 2 1 1 3 3 3 1 F actin bundling C terminal AsmA PF05170.14 ELR23969.1 - 0.12 11.1 8.7 0.18 10.6 8.7 1.3 1 0 0 1 1 1 0 AsmA family TFIIA PF03153.13 ELR23969.1 - 6.9 6.5 27.8 12 5.8 27.8 1.4 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit mRNA_triPase PF02940.15 ELR23970.1 - 4.1e-38 131.3 1.2 4.1e-38 131.3 1.2 1.6 2 0 0 2 2 2 1 mRNA capping enzyme, beta chain Ribosomal_L29e PF01779.17 ELR23971.1 - 2.3e-20 72.6 11.6 2.3e-20 72.6 11.6 1.7 2 0 0 2 2 2 1 Ribosomal L29e protein family tRNA_int_end_N2 PF12928.7 ELR23972.1 - 6.7e-10 39.0 0.0 1e-09 38.4 0.0 1.3 1 0 0 1 1 1 1 tRNA-splicing endonuclease subunit sen54 N-term F_actin_bund_C PF18060.1 ELR23973.1 - 1.2e-17 63.7 17.6 1.2e-17 63.7 17.6 4.0 1 1 2 3 3 3 1 F actin bundling C terminal AsmA PF05170.14 ELR23973.1 - 0.061 12.1 10.2 0.087 11.6 10.2 1.2 1 0 0 1 1 1 0 AsmA family TFIIA PF03153.13 ELR23973.1 - 2.9 7.8 23.1 4.6 7.1 23.1 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF4286 PF14114.6 ELR23974.1 - 5.6e-05 23.5 0.0 0.00012 22.5 0.0 1.5 2 0 0 2 2 2 1 Domain of unknown function (DUF4286) MSA-2c PF12238.8 ELR23974.1 - 2 8.4 4.9 2.5 8.0 4.9 1.2 1 0 0 1 1 1 0 Merozoite surface antigen 2c FF PF01846.19 ELR23975.1 - 8.6e-53 176.3 14.2 1e-13 51.2 0.7 5.4 5 0 0 5 5 5 5 FF domain RhoGAP-FF1 PF16512.5 ELR23975.1 - 6.6e-06 26.7 5.2 0.00015 22.4 0.1 4.0 2 2 2 4 4 4 1 p190-A and -B Rho GAPs FF domain TEA PF01285.18 ELR23975.1 - 0.042 13.9 0.0 13 6.0 0.0 2.7 2 0 0 2 2 2 0 TEA/ATTS domain DUF3915 PF13054.6 ELR23975.1 - 0.31 11.0 3.7 0.58 10.1 3.7 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) LMBR1 PF04791.16 ELR23975.1 - 0.44 9.4 1.1 0.54 9.1 1.1 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein PLN_propep PF16485.5 ELR23976.1 - 0.014 15.1 3.1 0.11 12.3 0.6 2.1 2 0 0 2 2 2 0 Protealysin propeptide zf-C3HC4_2 PF13923.6 ELR23977.1 - 5.9e-08 32.4 4.0 1.7e-07 30.9 4.0 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 ELR23977.1 - 1.4e-06 28.2 4.4 3.1e-06 27.1 4.4 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-rbx1 PF12678.7 ELR23977.1 - 6.3e-06 26.4 2.8 6.3e-06 26.4 2.8 2.1 2 0 0 2 2 1 1 RING-H2 zinc finger domain zf-Nse PF11789.8 ELR23977.1 - 1.1e-05 25.2 0.1 2.5e-05 24.0 0.1 1.6 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_2 PF13639.6 ELR23977.1 - 0.00012 22.3 3.3 0.00012 22.3 3.3 2.2 3 0 0 3 3 1 1 Ring finger domain zf-C3HC4 PF00097.25 ELR23977.1 - 0.00014 21.6 2.2 0.00039 20.2 2.2 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_6 PF14835.6 ELR23977.1 - 0.00056 19.7 0.1 0.0012 18.7 0.1 1.6 1 0 0 1 1 1 1 zf-RING of BARD1-type protein zf-C3HC4_4 PF15227.6 ELR23977.1 - 0.0011 19.1 1.5 0.0011 19.1 1.5 1.8 2 0 0 2 2 1 1 zinc finger of C3HC4-type, RING Prok-RING_4 PF14447.6 ELR23977.1 - 0.006 16.4 3.9 0.017 14.9 3.9 1.8 1 1 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_3 PF13920.6 ELR23977.1 - 0.0075 16.1 1.7 0.0075 16.1 1.7 2.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) DUF2201_N PF13203.6 ELR23977.1 - 0.01 15.5 7.6 0.018 14.6 7.6 1.5 1 0 0 1 1 1 0 Putative metallopeptidase domain zf-MIZ PF02891.20 ELR23977.1 - 0.039 13.7 2.6 0.079 12.7 2.6 1.6 1 0 0 1 1 1 0 MIZ/SP-RING zinc finger zf-RING_10 PF16685.5 ELR23977.1 - 0.046 13.9 4.1 0.057 13.6 2.4 1.9 2 0 0 2 2 2 0 zinc RING finger of MSL2 zf-ANAPC11 PF12861.7 ELR23977.1 - 0.05 13.7 7.2 0.12 12.4 2.3 2.9 2 1 1 3 3 3 0 Anaphase-promoting complex subunit 11 RING-H2 finger U-box PF04564.15 ELR23977.1 - 0.1 12.8 0.0 0.23 11.6 0.0 1.5 1 0 0 1 1 1 0 U-box domain SpoIIIAH PF12685.7 ELR23977.1 - 0.18 11.6 9.7 0.33 10.8 9.7 1.3 1 0 0 1 1 1 0 SpoIIIAH-like protein IBR PF01485.21 ELR23977.1 - 0.21 11.9 2.0 0.36 11.1 0.7 2.1 2 0 0 2 2 2 0 IBR domain, a half RING-finger domain zf-RING_5 PF14634.6 ELR23977.1 - 0.38 10.7 9.1 0.064 13.2 4.4 2.2 2 1 1 3 3 2 0 zinc-RING finger domain CDC45 PF02724.14 ELR23977.1 - 2 6.6 16.4 3.7 5.7 16.4 1.5 1 0 0 1 1 1 0 CDC45-like protein Med12 PF09497.10 ELR23978.1 - 1.6e-13 50.7 0.1 6.2e-13 48.8 0.1 2.1 1 0 0 1 1 1 1 Transcription mediator complex subunit Med12 Med12-LCEWAV PF12145.8 ELR23978.1 - 3.9e-09 35.9 0.8 3.9e-09 35.9 0.8 3.8 4 1 0 4 4 4 1 Eukaryotic Mediator 12 subunit domain TCP PF03634.13 ELR23978.1 - 3.6 8.1 9.4 0.27 11.8 0.1 3.1 3 0 0 3 3 3 0 TCP family transcription factor SAP PF02037.27 ELR23979.1 - 0.048 13.4 0.3 16 5.4 0.1 3.2 2 0 0 2 2 2 0 SAP domain Vac7 PF12751.7 ELR23979.1 - 1.5 8.2 9.1 4 6.8 0.1 2.2 2 0 0 2 2 2 0 Vacuolar segregation subunit 7 CDC45 PF02724.14 ELR23979.1 - 4.6 5.4 11.5 7.1 4.8 11.5 1.4 1 0 0 1 1 1 0 CDC45-like protein YL1 PF05764.13 ELR23979.1 - 7 6.7 28.8 4.6 7.3 15.1 2.5 1 1 1 2 2 2 0 YL1 nuclear protein COX6B PF02297.17 ELR23980.1 - 2.2e-14 53.4 0.4 3.1e-14 53.0 0.4 1.2 1 0 0 1 1 1 1 Cytochrome oxidase c subunit VIb Ribosomal_S17 PF00366.20 ELR23981.1 - 2e-16 59.8 3.8 3.1e-16 59.2 3.8 1.3 1 0 0 1 1 1 1 Ribosomal protein S17 Amidase_6 PF12671.7 ELR23981.1 - 0.047 13.8 0.2 0.079 13.1 0.2 1.5 1 1 0 1 1 1 0 Putative amidase domain Sec23_trunk PF04811.15 ELR23982.1 - 4.3e-22 78.9 0.2 5.5e-15 55.6 0.0 2.3 1 1 1 2 2 2 2 Sec23/Sec24 trunk domain zf-Sec23_Sec24 PF04810.15 ELR23982.1 - 4.8e-07 29.7 4.0 1.2e-06 28.5 4.0 1.6 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Sec23_helical PF04815.15 ELR23982.1 - 6.2e-07 29.2 0.1 1.3e-06 28.1 0.1 1.6 1 0 0 1 1 1 1 Sec23/Sec24 helical domain Sec23_BS PF08033.12 ELR23982.1 - 8.5e-07 29.6 0.0 1.8e-06 28.6 0.0 1.5 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain Gelsolin PF00626.22 ELR23982.1 - 4e-06 26.6 0.0 1e-05 25.3 0.0 1.7 1 1 0 1 1 1 1 Gelsolin repeat FAM76 PF16046.5 ELR23982.1 - 3.9 6.7 6.7 1.8 7.9 0.0 2.1 2 0 0 2 2 2 0 FAM76 protein F_actin_bund_C PF18060.1 ELR23983.1 - 6.4e-15 55.0 15.3 6.4e-15 55.0 15.3 3.8 2 1 1 3 3 3 1 F actin bundling C terminal LEM PF03020.15 ELR23983.1 - 0.078 12.6 0.0 0.19 11.3 0.0 1.6 1 0 0 1 1 1 0 LEM domain SAVED PF18145.1 ELR23983.1 - 0.69 9.7 6.1 0.14 12.0 0.3 2.2 2 1 1 3 3 3 0 SMODS-associated and fused to various effectors sensor domain Papilin_u7 PF16626.5 ELR23983.1 - 0.99 10.0 3.7 1.1 9.9 0.1 2.6 2 1 0 3 3 3 0 Linking region between Kunitz_BPTI and I-set on papilin TMPIT PF07851.13 ELR23983.1 - 7 5.8 12.5 3.6 6.8 1.8 2.4 1 1 1 2 2 2 0 TMPIT-like protein DUF5320 PF17253.2 ELR23983.1 - 9.6 7.3 9.2 2.7 9.1 1.9 2.6 2 0 0 2 2 2 0 Family of unknown function (DUF5320) NUDIX PF00293.28 ELR23985.1 - 3e-18 66.1 0.1 1.2e-17 64.2 0.1 1.9 2 0 0 2 2 2 1 NUDIX domain NUDIX-like PF09296.11 ELR23985.1 - 1.1e-11 45.3 0.1 2e-11 44.5 0.1 1.5 1 0 0 1 1 1 1 NADH pyrophosphatase-like rudimentary NUDIX domain zf-NADH-PPase PF09297.11 ELR23985.1 - 1.9e-08 33.8 1.6 1.9e-08 33.8 1.6 1.8 2 0 0 2 2 2 1 NADH pyrophosphatase zinc ribbon domain DNA_ligase_ZBD PF03119.16 ELR23985.1 - 0.42 10.7 3.8 0.21 11.6 1.0 2.0 2 0 0 2 2 2 0 NAD-dependent DNA ligase C4 zinc finger domain Coatomer_WDAD PF04053.14 ELR23986.1 - 0.00044 19.4 0.0 0.82 8.6 0.0 3.5 4 0 0 4 4 4 2 Coatomer WD associated region WD40 PF00400.32 ELR23986.1 - 0.41 11.6 2.0 60 4.8 0.0 5.1 6 0 0 6 6 6 0 WD domain, G-beta repeat Ribosomal_S10 PF00338.22 ELR23987.1 - 3e-21 75.5 0.1 3.8e-21 75.2 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein S10p/S20e tRNA-Thr_ED PF08915.11 ELR23987.1 - 0.0062 16.6 0.1 0.037 14.1 0.0 2.1 3 0 0 3 3 3 1 Archaea-specific editing domain of threonyl-tRNA synthetase LMF1 PF06762.14 ELR23989.1 - 7.4e-81 272.5 16.7 4.6e-42 144.6 1.6 2.1 1 1 1 2 2 2 2 Lipase maturation factor D123 PF07065.14 ELR23990.1 - 1.4e-18 67.1 4.2 2.8e-18 66.1 0.2 2.5 3 0 0 3 3 3 1 D123 Ras PF00071.22 ELR23990.1 - 2.8e-15 56.3 0.0 8.9e-15 54.7 0.0 1.8 1 1 0 1 1 1 1 Ras family Roc PF08477.13 ELR23990.1 - 1.6e-06 28.3 0.0 3.3e-05 24.1 0.0 2.9 2 1 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase AAA_22 PF13401.6 ELR23990.1 - 0.039 14.2 0.0 1.1 9.6 0.0 2.5 1 1 1 2 2 2 0 AAA domain TniB PF05621.11 ELR23990.1 - 0.078 12.4 0.0 0.14 11.5 0.0 1.4 1 0 0 1 1 1 0 Bacterial TniB protein V-SNARE_C PF12352.8 ELR23991.1 - 2.5e-14 53.3 5.5 2.5e-14 53.3 2.0 2.0 1 1 1 2 2 2 2 Snare region anchored in the vesicle membrane C-terminus Laminin_I PF06008.14 ELR23991.1 - 0.0012 18.6 1.0 0.0015 18.3 1.0 1.0 1 0 0 1 1 1 1 Laminin Domain I Sec20 PF03908.13 ELR23991.1 - 0.0028 17.6 0.4 0.0066 16.3 0.2 1.6 1 1 1 2 2 2 1 Sec20 PMC2NT PF08066.12 ELR23991.1 - 0.019 15.7 0.6 0.028 15.1 0.6 1.3 1 0 0 1 1 1 0 PMC2NT (NUC016) domain MPS2 PF17060.5 ELR23991.1 - 0.032 13.5 0.2 0.036 13.4 0.2 1.2 1 0 0 1 1 1 0 Monopolar spindle protein 2 FtsL PF04999.13 ELR23991.1 - 0.046 13.7 0.5 0.046 13.7 0.5 2.4 2 1 1 3 3 3 0 Cell division protein FtsL Fusion_gly PF00523.18 ELR23991.1 - 0.065 11.5 0.3 0.075 11.3 0.3 1.1 1 0 0 1 1 1 0 Fusion glycoprotein F0 Cir_Bir_Yir PF06022.11 ELR23991.1 - 0.066 12.7 0.0 0.071 12.6 0.0 1.1 1 0 0 1 1 1 0 Plasmodium variant antigen protein Cir/Yir/Bir Zn_clus PF00172.18 ELR23992.1 - 1.6e-05 24.9 10.5 3.3e-05 23.9 10.5 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain PspA_IM30 PF04012.12 ELR23992.1 - 0.025 14.2 1.7 0.041 13.5 1.7 1.3 1 0 0 1 1 1 0 PspA/IM30 family PAS_9 PF13426.7 ELR23992.1 - 0.1 12.9 0.0 0.38 11.0 0.0 2.0 2 0 0 2 2 2 0 PAS domain CsbD PF05532.12 ELR23993.1 - 0.043 13.7 0.5 0.076 12.9 0.5 1.3 1 0 0 1 1 1 0 CsbD-like Ribosomal_L12_N PF16320.5 ELR23993.1 - 0.076 12.7 0.3 0.2 11.4 0.3 1.7 1 0 0 1 1 1 0 Ribosomal protein L7/L12 dimerisation domain Ank_4 PF13637.6 ELR23994.1 - 1.6e-14 54.0 0.1 2.4e-07 31.2 0.0 3.2 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 ELR23994.1 - 4.4e-14 52.8 0.6 7.4e-13 48.9 0.1 2.8 2 1 1 3 3 3 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 ELR23994.1 - 2.2e-10 39.8 0.1 0.00011 22.3 0.0 4.7 5 0 0 5 5 5 2 Ankyrin repeat Ank PF00023.30 ELR23994.1 - 5.2e-07 29.8 0.1 0.002 18.5 0.0 3.6 4 0 0 4 4 4 2 Ankyrin repeat Ank_5 PF13857.6 ELR23994.1 - 8.5e-07 29.1 0.0 2.6e-06 27.6 0.0 1.9 2 0 0 2 2 2 1 Ankyrin repeats (many copies) SR-25 PF10500.9 ELR23994.1 - 9.3 5.8 8.3 19 4.8 8.3 1.4 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein VCBS PF13517.6 ELR23998.1 - 8.7e-34 115.9 49.1 8.9e-11 42.2 2.1 5.6 3 2 3 6 6 6 6 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.23 ELR23998.1 - 8.4e-17 61.0 45.0 0.0038 17.3 0.1 8.1 7 1 1 8 8 8 6 FG-GAP repeat TcdB_toxin_midN PF12256.8 ELR23998.1 - 1.8e-06 27.4 17.7 1.6 8.0 0.2 6.4 2 2 5 7 7 7 5 Insecticide toxin TcdB middle/N-terminal region BBS2_Mid PF14783.6 ELR23998.1 - 8.5e-05 22.6 1.8 58 3.8 0.0 6.1 6 1 1 7 7 7 0 Ciliary BBSome complex subunit 2, middle region EF-hand_5 PF13202.6 ELR23998.1 - 0.11 12.0 0.3 0.11 12.0 0.3 4.7 5 0 0 5 5 5 0 EF hand Dockerin_1 PF00404.18 ELR23998.1 - 0.45 10.7 15.8 0.96 9.7 0.2 5.5 5 1 1 6 6 6 0 Dockerin type I domain ribosomal_L24 PF17136.4 ELR23999.1 - 4.6e-20 71.8 1.5 9.7e-20 70.7 0.1 2.1 2 0 0 2 2 2 1 Ribosomal proteins 50S L24/mitochondrial 39S L24 KOW PF00467.29 ELR23999.1 - 0.00087 19.2 4.8 0.0021 17.9 4.8 1.7 1 0 0 1 1 1 1 KOW motif Nop16 PF09420.10 ELR24000.1 - 1.6e-17 64.2 10.0 1.9e-11 44.4 0.9 2.9 2 1 1 3 3 3 2 Ribosome biogenesis protein Nop16 PPP4R2 PF09184.11 ELR24000.1 - 0.16 11.6 13.7 0.18 11.4 13.7 1.1 1 0 0 1 1 1 0 PPP4R2 NOA36 PF06524.12 ELR24000.1 - 0.2 10.9 19.5 0.3 10.4 19.5 1.3 1 0 0 1 1 1 0 NOA36 protein TLP-20 PF06088.11 ELR24000.1 - 2.9 7.8 6.5 0.45 10.4 2.4 1.7 2 0 0 2 2 2 0 Nucleopolyhedrovirus telokin-like protein-20 (TLP20) Cwf_Cwc_15 PF04889.12 ELR24000.1 - 2.9 7.5 23.8 0.38 10.4 15.3 2.3 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein DNA_pol_phi PF04931.13 ELR24000.1 - 3.1 5.8 24.5 3.9 5.5 24.5 1.1 1 0 0 1 1 1 0 DNA polymerase phi TonB_N PF16031.5 ELR24000.1 - 7 7.2 12.9 3.4 8.2 4.6 2.2 1 1 1 2 2 2 0 TonB polyproline region Renin_r PF07850.14 ELR24001.1 - 3.4e-06 27.6 0.0 3.4e-06 27.6 0.0 1.1 1 0 0 1 1 1 1 Renin receptor-like protein LBP_BPI_CETP_C PF02886.17 ELR24003.1 - 6.2e-15 55.3 0.0 1.1e-14 54.5 0.0 1.5 1 0 0 1 1 1 1 LBP / BPI / CETP family, C-terminal domain LBP_BPI_CETP PF01273.25 ELR24003.1 - 0.0069 16.0 0.1 0.014 15.0 0.1 1.5 1 0 0 1 1 1 1 LBP / BPI / CETP family, N-terminal domain zf-Sec23_Sec24 PF04810.15 ELR24004.1 - 1.2e-07 31.7 0.0 2.7e-07 30.5 0.0 1.7 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Sec23_BS PF08033.12 ELR24004.1 - 0.00033 21.3 0.0 0.0009 19.9 0.0 1.7 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain Sec23_trunk PF04811.15 ELR24004.1 - 0.00067 19.3 0.0 0.0077 15.8 0.0 2.5 1 1 0 1 1 1 1 Sec23/Sec24 trunk domain VWA_2 PF13519.6 ELR24004.1 - 0.0013 19.4 3.7 0.43 11.2 0.3 4.2 2 1 0 2 2 2 1 von Willebrand factor type A domain adh_short_C2 PF13561.6 ELR24004.1 - 0.029 13.9 0.0 0.067 12.7 0.0 1.5 1 0 0 1 1 1 0 Enoyl-(Acyl carrier protein) reductase VWA PF00092.28 ELR24004.1 - 0.067 13.4 0.4 9 6.5 0.1 3.4 2 1 1 3 3 3 0 von Willebrand factor type A domain Homeodomain PF00046.29 ELR24005.1 - 1.1e-17 63.6 2.2 2.2e-17 62.7 2.2 1.5 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 ELR24005.1 - 1.8e-05 24.5 0.1 4.4e-05 23.3 0.1 1.6 1 0 0 1 1 1 1 Homeobox KN domain PA26 PF04636.13 ELR24005.1 - 3 6.7 5.8 0.69 8.8 2.4 1.6 2 0 0 2 2 2 0 PA26 p53-induced protein (sestrin) Ribosomal_60s PF00428.19 ELR24006.1 - 1.1e-15 58.0 6.4 1.5e-15 57.5 6.4 1.2 1 0 0 1 1 1 1 60s Acidic ribosomal protein PDEase_II PF02112.15 ELR24007.1 - 3.5e-40 138.2 0.0 1.3e-23 83.7 0.0 2.1 1 1 1 2 2 2 2 cAMP phosphodiesterases class-II Lactamase_B_2 PF12706.7 ELR24007.1 - 0.0032 17.0 0.0 0.0082 15.7 0.0 1.7 2 0 0 2 2 2 1 Beta-lactamase superfamily domain GRDP-like PF07173.12 ELR24008.1 - 5.7e-17 62.7 1.1 1.7e-09 38.5 0.0 3.0 1 1 1 2 2 2 2 Glycine-rich domain-containing protein-like Ras PF00071.22 ELR24009.1 - 1.6e-40 138.3 0.0 1.9e-40 138.1 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR24009.1 - 2.8e-27 95.3 0.0 3.8e-27 94.9 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR24009.1 - 4.6e-13 49.0 0.0 5.9e-13 48.6 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 ELR24009.1 - 0.0007 19.7 0.0 0.00092 19.3 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 ELR24009.1 - 0.0037 17.2 0.0 0.55 10.1 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase Gtr1_RagA PF04670.12 ELR24009.1 - 0.029 13.7 0.0 0.055 12.8 0.0 1.4 1 1 0 1 1 1 0 Gtr1/RagA G protein conserved region RhoGEF PF00621.20 ELR24010.1 - 2.1e-23 83.5 5.3 1.2e-19 71.3 3.5 2.5 1 1 1 2 2 2 2 RhoGEF domain C2 PF00168.30 ELR24010.1 - 0.00038 20.7 0.0 0.00085 19.6 0.0 1.7 1 0 0 1 1 1 1 C2 domain PH PF00169.29 ELR24010.1 - 0.005 17.3 0.0 0.21 12.1 0.0 3.3 2 1 0 2 2 2 1 PH domain IQ_SEC7_PH PF16453.5 ELR24010.1 - 0.025 14.6 2.2 0.22 11.5 0.0 3.2 4 0 0 4 4 4 0 PH domain Pannexin_like PF12534.8 ELR24010.1 - 1.5 7.8 0.0 1.5 7.8 0.0 3.4 4 1 0 4 4 4 0 Pannexin-like TM region of LRRC8 Cupin_8 PF13621.6 ELR24011.1 - 1.9e-20 73.7 0.7 5.1e-19 69.0 0.7 2.2 1 1 0 1 1 1 1 Cupin-like domain JmjC PF02373.22 ELR24011.1 - 2.5e-09 37.6 0.2 8.6e-08 32.6 0.2 2.4 1 1 0 1 1 1 1 JmjC domain, hydroxylase F-box-like PF12937.7 ELR24011.1 - 3.1e-06 27.0 0.0 5.2e-06 26.3 0.0 1.4 1 0 0 1 1 1 1 F-box-like Cupin_4 PF08007.12 ELR24011.1 - 5.1e-06 26.2 0.0 8.7e-06 25.4 0.0 1.3 1 0 0 1 1 1 1 Cupin superfamily protein F-box PF00646.33 ELR24011.1 - 1.6e-05 24.7 0.0 2.8e-05 23.9 0.0 1.4 1 0 0 1 1 1 1 F-box domain Cupin_2 PF07883.11 ELR24011.1 - 0.016 14.9 0.0 0.04 13.6 0.0 1.7 1 0 0 1 1 1 0 Cupin domain Cupin_1 PF00190.22 ELR24011.1 - 0.14 11.8 0.0 0.26 10.9 0.0 1.4 1 0 0 1 1 1 0 Cupin DSPc PF00782.20 ELR24012.1 - 1.3e-38 131.9 0.1 2e-38 131.2 0.1 1.3 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.6 ELR24012.1 - 5.8e-06 26.5 0.0 8.5e-06 26.0 0.0 1.2 1 0 0 1 1 1 1 Inositol hexakisphosphate Y_phosphatase PF00102.27 ELR24012.1 - 1.4e-05 24.8 0.1 2.6e-05 23.9 0.1 1.5 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Rhodanese PF00581.20 ELR24012.1 - 7.5e-05 23.2 0.3 0.012 16.2 0.0 2.5 2 1 0 2 2 2 1 Rhodanese-like domain CDKN3 PF05706.12 ELR24012.1 - 0.00026 20.7 0.0 0.00044 20.0 0.0 1.3 1 0 0 1 1 1 1 Cyclin-dependent kinase inhibitor 3 (CDKN3) Y_phosphatase2 PF03162.13 ELR24012.1 - 0.00037 20.1 0.1 0.00074 19.1 0.1 1.5 1 0 0 1 1 1 1 Tyrosine phosphatase family Init_tRNA_PT PF04179.12 ELR24012.1 - 0.0024 18.1 0.0 0.0042 17.4 0.0 1.4 1 0 0 1 1 1 1 Rit1 DUSP-like domain Y_phosphatase3 PF13350.6 ELR24012.1 - 0.028 14.4 0.0 0.13 12.2 0.0 1.9 2 0 0 2 2 2 0 Tyrosine phosphatase family CsbD PF05532.12 ELR24013.1 - 4.4e-08 32.9 0.9 7.5e-07 29.0 0.2 2.0 2 0 0 2 2 2 2 CsbD-like SUI1 PF01253.22 ELR24014.1 - 5.8e-20 71.6 0.2 1.2e-19 70.5 0.2 1.6 1 0 0 1 1 1 1 Translation initiation factor SUI1 Pre-PUA PF17832.1 ELR24014.1 - 2.3e-06 28.2 0.3 5.1e-05 23.9 0.3 2.5 1 1 0 1 1 1 1 Pre-PUA-like domain SWIB PF02201.18 ELR24014.1 - 0.0013 18.6 0.0 0.003 17.4 0.0 1.5 1 0 0 1 1 1 1 SWIB/MDM2 domain VKG_Carbox PF05090.14 ELR24015.1 - 7.8e-69 232.6 8.6 2.2e-27 96.0 0.2 3.0 2 1 1 3 3 3 3 Vitamin K-dependent gamma-carboxylase Methyltrans_SAM PF10672.9 ELR24016.1 - 3.3e-14 52.7 0.0 1.2e-12 47.6 0.0 2.1 1 1 0 1 1 1 1 S-adenosylmethionine-dependent methyltransferase Cons_hypoth95 PF03602.15 ELR24016.1 - 0.18 11.4 0.1 0.76 9.4 0.1 1.9 1 1 0 1 1 1 0 Conserved hypothetical protein 95 WH2 PF02205.20 ELR24018.1 - 0.00011 22.0 0.1 0.00011 22.0 0.1 2.3 2 0 0 2 2 2 1 WH2 motif PNISR PF15996.5 ELR24018.1 - 0.04 14.2 5.6 0.063 13.5 5.6 1.3 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR Med9 PF07544.13 ELR24018.1 - 0.06 13.4 0.0 0.06 13.4 0.0 2.8 2 1 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 2-Hacid_dh_C PF02826.19 ELR24020.1 - 4.4e-50 169.5 0.0 1.7e-48 164.3 0.0 2.1 1 1 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 ELR24020.1 - 3e-27 94.9 0.0 3.7e-27 94.6 0.0 1.1 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain IlvN PF07991.12 ELR24020.1 - 0.048 13.2 0.0 0.095 12.3 0.0 1.5 1 0 0 1 1 1 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain F420_oxidored PF03807.17 ELR24020.1 - 0.061 13.9 0.0 0.15 12.7 0.0 1.7 2 0 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent Pkinase PF00069.25 ELR24021.1 - 1.3e-32 113.2 0.0 2.8e-16 59.7 0.0 2.7 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ELR24021.1 - 1.8e-28 99.6 0.0 2.7e-13 49.8 0.0 2.3 1 1 1 2 2 2 2 Protein tyrosine kinase Cnd1_N PF12922.7 ELR24021.1 - 0.027 14.3 0.6 0.027 14.3 0.6 2.2 2 0 0 2 2 2 0 non-SMC mitotic condensation complex subunit 1, N-term LEA_6 PF10714.9 ELR24021.1 - 0.068 13.2 0.3 0.16 12.0 0.3 1.6 1 0 0 1 1 1 0 Late embryogenesis abundant protein 18 AP3D1 PF06375.11 ELR24021.1 - 0.68 10.2 25.6 1.2 9.3 5.2 2.5 2 0 0 2 2 2 0 AP-3 complex subunit delta-1 FMN_red PF03358.15 ELR24022.1 - 2.8e-30 105.1 0.0 4.3e-30 104.5 0.0 1.3 1 0 0 1 1 1 1 NADPH-dependent FMN reductase Flavodoxin_2 PF02525.17 ELR24022.1 - 4.2e-10 39.6 0.2 8e-10 38.7 0.1 1.5 1 1 0 1 1 1 1 Flavodoxin-like fold Filo_VP35 PF02097.15 ELR24024.1 - 0.17 10.9 0.0 0.17 10.9 0.0 1.1 1 0 0 1 1 1 0 Filoviridae VP35 Nucleoporin2 PF04096.14 ELR24025.1 - 2.4e-34 118.6 0.0 3.8e-34 118.0 0.0 1.3 1 0 0 1 1 1 1 Nucleoporin autopeptidase Nucleoporin_FG PF13634.6 ELR24025.1 - 1.3e-17 64.4 212.4 1.4e-06 29.1 25.8 8.3 2 2 6 8 8 8 6 Nucleoporin FG repeat region SnoaL_2 PF12680.7 ELR24027.1 - 6.3e-10 39.6 0.1 1.3e-09 38.6 0.1 1.5 1 1 0 1 1 1 1 SnoaL-like domain SnoaL_4 PF13577.6 ELR24027.1 - 0.013 15.6 0.0 0.015 15.4 0.0 1.2 1 0 0 1 1 1 0 SnoaL-like domain SnoaL PF07366.12 ELR24027.1 - 0.038 13.8 0.0 0.47 10.3 0.0 2.1 1 1 0 1 1 1 0 SnoaL-like polyketide cyclase DUF4440 PF14534.6 ELR24027.1 - 0.08 13.4 0.0 0.13 12.7 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4440) DUF4461 PF14688.6 ELR24028.1 - 1.3e-05 25.2 0.1 0.032 14.0 0.1 2.1 1 1 0 2 2 2 2 Domain of unknown function (DUF4461) DUF4460 PF14687.6 ELR24028.1 - 0.00027 20.9 0.0 0.00073 19.6 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4460) Gelsolin PF00626.22 ELR24029.1 - 2.8e-20 72.0 0.0 1.6e-10 40.7 0.0 2.9 2 0 0 2 2 2 2 Gelsolin repeat PH PF00169.29 ELR24029.1 - 4.3e-08 33.6 4.5 1e-07 32.4 4.5 1.7 1 0 0 1 1 1 1 PH domain PH_9 PF15410.6 ELR24029.1 - 8.1e-05 23.0 7.7 0.0015 18.9 7.7 2.4 1 1 0 1 1 1 1 Pleckstrin homology domain BUD22 PF09073.10 ELR24029.1 - 0.016 14.5 46.8 0.028 13.8 46.8 1.5 1 0 0 1 1 1 0 BUD22 PH_13 PF16652.5 ELR24029.1 - 0.1 12.4 6.1 0.17 11.7 3.2 2.6 2 1 0 2 2 2 0 Pleckstrin homology domain DUF966 PF06136.13 ELR24029.1 - 1.2 8.7 26.3 1.9 8.1 26.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF966) Ndc1_Nup PF09531.10 ELR24029.1 - 3.4 6.3 12.7 5.2 5.6 12.7 1.3 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup ATP-synt_C PF00137.21 ELR24030.1 - 3.4e-25 88.1 32.1 1.4e-14 54.1 12.7 2.1 2 0 0 2 2 2 2 ATP synthase subunit C G0-G1_switch_2 PF15103.6 ELR24030.1 - 0.081 13.4 0.3 0.19 12.2 0.3 1.7 1 0 0 1 1 1 0 G0/G1 switch protein 2 SLATT_5 PF18160.1 ELR24030.1 - 0.3 10.4 0.5 0.42 9.9 0.0 1.5 2 0 0 2 2 2 0 SMODS and SLOG-associating 2TM effector domain family 5 PIRT PF15099.6 ELR24030.1 - 1.5 8.4 5.1 3.3 7.3 0.8 2.3 1 1 1 2 2 2 0 Phosphoinositide-interacting protein family ABC_trans_N PF14510.6 ELR24031.1 - 2.1 9.0 0.0 2.1 9.0 0.0 4.4 2 1 0 2 2 2 0 ABC-transporter N-terminal AAA_21 PF13304.6 ELR24031.1 - 3.6 7.3 5.6 4.9 6.9 5.4 1.3 1 1 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system PAT1 PF09770.9 ELR24031.1 - 8.9 4.4 42.8 11 4.1 42.8 1.3 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Rap_GAP PF02145.15 ELR24032.1 - 3.8e-48 163.5 0.1 7e-48 162.6 0.1 1.5 1 0 0 1 1 1 1 Rap/ran-GAP LRR_8 PF13855.6 ELR24032.1 - 5.9e-19 67.6 11.9 5.5e-08 32.5 0.5 4.5 2 2 2 4 4 4 4 Leucine rich repeat LRR_4 PF12799.7 ELR24032.1 - 6.3e-17 61.4 12.7 1.2e-06 28.8 0.3 4.8 2 2 1 4 4 4 4 Leucine Rich repeats (2 copies) SH2 PF00017.24 ELR24032.1 - 1.2e-09 38.1 0.1 3.6e-09 36.6 0.1 1.8 1 0 0 1 1 1 1 SH2 domain LRR_9 PF14580.6 ELR24032.1 - 1.5e-09 37.6 3.6 0.00023 20.7 0.6 2.6 2 0 0 2 2 2 2 Leucine-rich repeat LRR_1 PF00560.33 ELR24032.1 - 4.6e-05 23.4 5.0 26 5.9 0.1 6.4 6 0 0 6 6 6 0 Leucine Rich Repeat LRR_6 PF13516.6 ELR24032.1 - 0.00014 21.6 7.4 1.1 9.4 0.0 6.1 6 0 0 6 6 6 1 Leucine Rich repeat Cullin_Nedd8 PF10557.9 ELR24032.1 - 0.097 12.7 0.1 0.31 11.1 0.1 1.9 1 0 0 1 1 1 0 Cullin protein neddylation domain FXMR_C2 PF16098.5 ELR24032.1 - 0.22 12.0 2.4 0.71 10.4 2.4 1.8 1 0 0 1 1 1 0 Fragile X-related mental retardation protein C-terminal region 2 NUDIX PF00293.28 ELR24033.1 - 0.08 13.0 0.2 1.3 9.1 0.1 2.2 2 0 0 2 2 2 0 NUDIX domain Pkinase_Tyr PF07714.17 ELR24034.1 - 2.2e-31 109.1 0.0 3.6e-31 108.4 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ELR24034.1 - 6.3e-18 65.1 0.0 1.4e-17 64.0 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain SH2 PF00017.24 ELR24034.1 - 9.5e-12 44.9 0.0 2.7e-11 43.4 0.0 1.8 1 0 0 1 1 1 1 SH2 domain F-box-like PF12937.7 ELR24034.1 - 3.1e-07 30.2 0.1 7.7e-07 28.9 0.1 1.6 1 0 0 1 1 1 1 F-box-like Cbl_N2 PF02761.14 ELR24034.1 - 0.019 15.6 0.0 0.14 12.9 0.0 2.2 2 0 0 2 2 2 0 CBL proto-oncogene N-terminus, EF hand-like domain F-box PF00646.33 ELR24034.1 - 0.023 14.6 0.1 0.052 13.4 0.1 1.6 1 0 0 1 1 1 0 F-box domain DUF2735 PF10931.8 ELR24034.1 - 0.45 11.2 0.0 0.45 11.2 0.0 3.7 5 0 0 5 5 5 0 Protein of unknown function (DUF2735) Syja_N PF02383.18 ELR24036.1 - 3.2e-64 217.3 0.1 3.2e-64 217.3 0.1 2.7 2 2 0 2 2 2 1 SacI homology domain FancD2 PF14631.6 ELR24036.1 - 0.97 6.7 2.7 1.4 6.2 2.7 1.1 1 0 0 1 1 1 0 Fanconi anaemia protein FancD2 nuclease CCDC106 PF15794.5 ELR24036.1 - 5.8 6.6 10.2 0.26 11.0 4.4 1.7 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 106 BSD PF03909.17 ELR24038.1 - 1.1e-08 35.0 0.1 2.1e-08 34.0 0.1 1.5 1 0 0 1 1 1 1 BSD domain Cwf_Cwc_15 PF04889.12 ELR24038.1 - 0.092 12.5 5.7 0.088 12.5 0.7 2.1 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein Retinal PF15449.6 ELR24038.1 - 3 5.5 7.5 3.8 5.2 7.5 1.0 1 0 0 1 1 1 0 Retinal protein RRM_1 PF00076.22 ELR24039.1 - 1.7e-14 53.4 0.0 2.6e-14 52.8 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 ELR24039.1 - 0.0033 17.5 0.0 0.0067 16.5 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif RRM_occluded PF16842.5 ELR24039.1 - 0.021 14.7 0.0 0.033 14.0 0.0 1.3 1 0 0 1 1 1 0 Occluded RNA-recognition motif Nup35_RRM_2 PF14605.6 ELR24039.1 - 0.035 14.1 0.0 0.058 13.4 0.0 1.3 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif RRM_3 PF08777.11 ELR24039.1 - 0.094 12.8 0.0 0.18 11.8 0.0 1.4 1 0 0 1 1 1 0 RNA binding motif UFD1 PF03152.14 ELR24040.1 - 9e-36 122.9 0.0 1.3e-35 122.4 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin fusion degradation protein UFD1 Ank_2 PF12796.7 ELR24041.1 - 2.3e-41 140.2 0.0 1.4e-13 51.2 0.1 3.6 3 1 0 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ELR24041.1 - 8.2e-32 109.2 0.5 3.9e-09 36.9 0.0 5.7 3 3 2 6 6 6 5 Ankyrin repeats (many copies) Ank_5 PF13857.6 ELR24041.1 - 3e-29 100.7 1.8 2.9e-08 33.8 0.0 6.4 3 3 4 7 7 7 7 Ankyrin repeats (many copies) Ank_3 PF13606.6 ELR24041.1 - 2.6e-26 88.8 0.0 6e-06 26.2 0.0 7.0 7 0 0 7 7 7 5 Ankyrin repeat Ank PF00023.30 ELR24041.1 - 1.3e-22 79.2 0.6 2.9e-06 27.5 0.0 5.6 6 1 0 6 6 6 3 Ankyrin repeat DUF1843 PF08898.10 ELR24041.1 - 0.055 14.0 5.4 25 5.5 0.0 4.8 5 0 0 5 5 5 0 Domain of unknown function (DUF1843) RasGAP PF00616.19 ELR24042.1 - 1.2e-10 41.5 5.7 7.3e-05 22.6 0.0 3.4 2 1 2 4 4 4 3 GTPase-activator protein for Ras-like GTPase TFIIA PF03153.13 ELR24043.1 - 0.34 10.8 11.3 0.48 10.3 11.3 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Nop14 PF04147.12 ELR24043.1 - 1.1 7.4 11.1 1.3 7.1 11.1 1.1 1 0 0 1 1 1 0 Nop14-like family SDA1 PF05285.12 ELR24043.1 - 1.5 8.2 9.8 2.2 7.6 9.8 1.4 1 0 0 1 1 1 0 SDA1 DNA_pol_phi PF04931.13 ELR24043.1 - 1.9 6.5 19.0 2.7 6.0 19.0 1.1 1 0 0 1 1 1 0 DNA polymerase phi Cwf_Cwc_15 PF04889.12 ELR24043.1 - 3.7 7.2 16.9 6.4 6.4 16.9 1.4 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein DUF2722 PF10846.8 ELR24043.1 - 7.9 5.3 5.9 10 4.9 5.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) CN_hydrolase PF00795.22 ELR24044.1 - 1.3e-57 195.1 0.0 1.6e-57 194.8 0.0 1.1 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase Maf1 PF09174.10 ELR24045.1 - 4.1e-62 209.4 2.1 4.8e-62 209.2 2.1 1.1 1 0 0 1 1 1 1 Maf1 regulator Ribosomal_L7Ae PF01248.26 ELR24046.1 - 2.3e-09 36.9 0.1 3.9e-09 36.1 0.1 1.4 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family SH2_2 PF14633.6 ELR24047.1 - 3.6e-45 154.0 0.8 5.5e-45 153.4 0.0 1.7 2 0 0 2 2 2 1 SH2 domain YqgF PF14639.6 ELR24047.1 - 6.7e-28 97.4 0.0 1.7e-27 96.1 0.0 1.7 1 0 0 1 1 1 1 Holliday-junction resolvase-like of SPT6 HHH_7 PF14635.6 ELR24047.1 - 1.9e-24 86.0 0.0 1.8e-23 82.9 0.0 2.6 2 1 0 2 2 2 1 Helix-hairpin-helix motif HTH_44 PF14641.6 ELR24047.1 - 9.8e-20 71.1 0.2 2.2e-19 70.0 0.2 1.6 1 0 0 1 1 1 1 Helix-turn-helix DNA-binding domain of SPT6 HHH_9 PF17674.1 ELR24047.1 - 1.6e-08 35.3 0.1 5.9e-08 33.5 0.1 2.1 1 0 0 1 1 1 1 HHH domain S1 PF00575.23 ELR24047.1 - 7.3e-08 32.6 0.0 2.1e-07 31.2 0.0 1.9 1 0 0 1 1 1 1 S1 RNA binding domain Tex_N PF09371.10 ELR24047.1 - 2.4e-07 30.6 0.0 1.8e-05 24.5 0.0 2.6 1 1 0 1 1 1 1 Tex-like protein N-terminal domain Tex_YqgF PF16921.5 ELR24047.1 - 6.2e-06 26.7 0.0 1.3e-05 25.6 0.0 1.6 1 0 0 1 1 1 1 Tex protein YqgF-like domain SH2 PF00017.24 ELR24047.1 - 0.0048 17.0 0.0 0.037 14.1 0.0 2.4 2 0 0 2 2 2 1 SH2 domain HHH_3 PF12836.7 ELR24047.1 - 0.08 13.2 0.0 0.43 10.9 0.0 2.3 1 0 0 1 1 1 0 Helix-hairpin-helix motif LRR_4 PF12799.7 ELR24048.1 - 8.9e-09 35.5 2.1 1.3e-05 25.4 0.5 3.3 2 1 1 3 3 3 2 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 ELR24048.1 - 3.8e-07 29.8 0.0 1.4e-06 27.9 0.0 2.0 1 1 0 1 1 1 1 Leucine-rich repeat LRR_8 PF13855.6 ELR24048.1 - 2.3e-06 27.3 3.4 4.5e-06 26.3 0.1 2.7 3 1 0 3 3 3 1 Leucine rich repeat Nup153 PF08604.10 ELR24048.1 - 0.063 12.1 3.8 0.086 11.6 3.8 1.2 1 0 0 1 1 1 0 Nucleoporin Nup153-like LRR_1 PF00560.33 ELR24048.1 - 0.37 11.5 1.9 1e+02 4.1 0.2 4.1 4 0 0 4 4 4 0 Leucine Rich Repeat NARP1 PF12569.8 ELR24048.1 - 0.9 8.4 7.7 1.2 7.9 7.7 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 WD40 PF00400.32 ELR24049.1 - 6.6e-57 188.2 28.4 8.8e-07 29.5 0.3 11.9 12 0 0 12 12 12 10 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ELR24049.1 - 2.5e-19 69.4 5.9 0.036 14.4 0.0 9.6 3 2 6 10 10 10 5 Anaphase-promoting complex subunit 4 WD40 domain Utp12 PF04003.12 ELR24049.1 - 1.5e-16 60.7 0.0 2.9e-16 59.7 0.0 1.5 1 0 0 1 1 1 1 Dip2/Utp12 Family Ge1_WD40 PF16529.5 ELR24049.1 - 2.5e-05 23.4 10.0 2.3 7.1 0.1 6.5 4 3 3 7 7 7 3 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ELR24049.1 - 2.8e-05 23.6 0.1 0.0058 16.0 0.0 4.0 4 2 1 5 5 5 1 WD40-like domain Nup160 PF11715.8 ELR24049.1 - 0.00082 18.1 9.7 0.36 9.4 0.0 5.6 4 1 0 6 6 6 2 Nucleoporin Nup120/160 Nucleoporin_N PF08801.11 ELR24049.1 - 0.012 14.4 0.9 2.2 6.9 0.0 3.8 2 2 1 4 4 4 0 Nup133 N terminal like PALB2_WD40 PF16756.5 ELR24049.1 - 0.024 13.6 1.7 12 4.7 0.0 4.1 4 0 0 4 4 4 0 Partner and localizer of BRCA2 WD40 domain Hira PF07569.11 ELR24049.1 - 0.45 10.2 5.4 37 3.9 0.0 4.5 4 1 1 5 5 5 0 TUP1-like enhancer of split Mit_KHE1 PF10173.9 ELR24050.1 - 4.5e-21 75.8 0.0 9e-19 68.3 0.0 2.1 1 1 0 1 1 1 1 Mitochondrial K+-H+ exchange-related CASP_C PF08172.12 ELR24051.1 - 5.5e-59 199.6 0.2 5.5e-59 199.6 0.2 3.9 2 2 1 3 3 3 1 CASP C terminal Leu_zip PF15294.6 ELR24051.1 - 0.0032 17.0 44.5 0.54 9.7 6.8 4.3 2 1 2 4 4 4 3 Leucine zipper CENP-H PF05837.12 ELR24051.1 - 0.0068 16.8 0.0 0.0068 16.8 0.0 5.9 4 1 3 7 7 7 1 Centromere protein H (CENP-H) FlaC_arch PF05377.11 ELR24051.1 - 0.087 13.2 33.1 0.43 11.0 0.1 7.8 6 2 1 7 7 7 0 Flagella accessory protein C (FlaC) DUF2730 PF10805.8 ELR24051.1 - 0.1 12.7 22.0 1.2 9.3 0.1 5.1 3 2 3 6 6 6 0 Protein of unknown function (DUF2730) Baculo_p24 PF05073.12 ELR24051.1 - 0.21 11.4 9.6 0.67 9.7 3.3 3.3 3 0 0 3 3 3 0 Baculovirus P24 capsid protein Golgin_A5 PF09787.9 ELR24051.1 - 0.26 10.7 58.6 1.1 8.7 0.0 5.4 3 1 2 5 5 5 0 Golgin subfamily A member 5 mCpol PF18182.1 ELR24051.1 - 0.3 11.4 6.5 1.1 9.6 0.1 3.7 3 1 1 4 4 4 0 minimal CRISPR polymerase domain YabA PF06156.13 ELR24051.1 - 0.36 11.5 0.0 0.36 11.5 0.0 6.1 3 1 3 6 6 4 0 Initiation control protein YabA DUF2031 PF09592.10 ELR24051.1 - 0.91 9.0 13.7 0.38 10.3 0.3 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF2031) Baculo_PEP_C PF04513.12 ELR24051.1 - 0.95 9.5 18.0 5.3 7.1 0.2 4.4 4 0 0 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus Phage_GP20 PF06810.11 ELR24051.1 - 1.5 8.7 40.6 1.3 8.9 5.8 5.5 2 1 2 4 4 4 0 Phage minor structural protein GP20 SlyX PF04102.12 ELR24051.1 - 1.8 9.2 0.0 1.8 9.2 0.0 8.9 4 2 5 9 9 9 0 SlyX Bacillus_HBL PF05791.11 ELR24051.1 - 2.3 8.0 27.4 1.7 8.4 5.4 4.7 4 2 0 4 4 4 0 Bacillus haemolytic enterotoxin (HBL) FliD_C PF07195.12 ELR24051.1 - 2.8 7.3 17.7 2.1 7.7 2.4 4.1 4 0 0 4 4 4 0 Flagellar hook-associated protein 2 C-terminus Seryl_tRNA_N PF02403.22 ELR24051.1 - 4.7 7.5 50.5 1.8 8.8 5.8 6.3 5 2 0 6 6 6 0 Seryl-tRNA synthetase N-terminal domain DUF1664 PF07889.12 ELR24051.1 - 8.3 6.5 33.6 0.45 10.6 0.1 5.3 5 1 1 6 6 6 0 Protein of unknown function (DUF1664) SNF2_N PF00176.23 ELR24052.1 - 2.1e-70 237.2 0.2 4.1e-70 236.3 0.2 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 ELR24052.1 - 1.7e-18 66.9 0.0 6.2e-18 65.2 0.0 2.0 1 1 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 ELR24052.1 - 2.2e-08 34.3 0.0 6.7e-08 32.7 0.0 1.8 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit HDA2-3 PF11496.8 ELR24052.1 - 1.2e-07 31.2 0.0 2.8e-07 30.0 0.0 1.5 1 0 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 DEAD PF00270.29 ELR24052.1 - 4.5e-05 23.3 0.0 9.8e-05 22.2 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase SWI2_SNF2 PF18766.1 ELR24052.1 - 0.006 16.3 0.0 0.017 14.8 0.0 1.8 1 0 0 1 1 1 1 SWI2/SNF2 ATPase ERCC3_RAD25_C PF16203.5 ELR24052.1 - 0.022 14.0 0.0 0.051 12.8 0.0 1.5 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase COG4 PF08318.12 ELR24052.1 - 0.47 9.5 2.3 0.48 9.4 0.6 1.8 2 0 0 2 2 2 0 COG4 transport protein Pkinase PF00069.25 ELR24053.1 - 3.9e-34 118.2 0.0 7.4e-34 117.3 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR24053.1 - 1.2e-22 80.4 0.0 1.9e-22 79.8 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase LRR_4 PF12799.7 ELR24053.1 - 2.4e-14 53.2 26.4 0.024 15.1 0.6 9.2 5 3 2 8 8 8 7 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 ELR24053.1 - 1.9e-06 27.4 17.7 1.8 8.8 0.0 9.6 10 0 0 10 10 10 3 Leucine Rich repeat Pkinase_fungal PF17667.1 ELR24053.1 - 6.6e-06 25.2 0.0 9.9e-06 24.6 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Amidohydro_1 PF01979.20 ELR24055.1 - 3.3e-35 122.0 0.3 4.2e-35 121.7 0.3 1.0 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 ELR24055.1 - 1.6e-08 34.5 0.6 2.3e-08 34.0 0.6 1.2 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_1 PF01979.20 ELR24056.1 - 1.4e-13 50.9 0.0 1.5e-13 50.8 0.0 1.0 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 ELR24056.1 - 6.3e-09 35.8 0.0 7.3e-09 35.6 0.0 1.0 1 0 0 1 1 1 1 Amidohydrolase family NTP_transf_2 PF01909.23 ELR24057.1 - 2.8e-07 30.7 0.0 7.7e-07 29.3 0.0 1.8 1 0 0 1 1 1 1 Nucleotidyltransferase domain PAP_assoc PF03828.19 ELR24057.1 - 4.4e-06 26.8 1.6 2.9e-05 24.2 1.6 2.5 1 1 0 1 1 1 1 Cid1 family poly A polymerase Polbeta PF18765.1 ELR24057.1 - 0.051 13.7 0.0 0.12 12.4 0.0 1.6 1 0 0 1 1 1 0 Polymerase beta, Nucleotidyltransferase Metallophos PF00149.28 ELR24059.1 - 2.7e-30 106.4 0.1 4.2e-30 105.8 0.0 1.3 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 ELR24059.1 - 0.086 13.0 0.0 0.13 12.4 0.0 1.3 1 0 0 1 1 1 0 Calcineurin-like phosphoesterase superfamily domain STPPase_N PF16891.5 ELR24059.1 - 0.22 12.0 0.0 1.2 9.6 0.0 2.0 2 0 0 2 2 2 0 Serine-threonine protein phosphatase N-terminal domain NUDIX PF00293.28 ELR24060.1 - 1.9e-13 50.6 0.0 4.8e-13 49.3 0.0 1.6 1 0 0 1 1 1 1 NUDIX domain NUDIX-like PF09296.11 ELR24060.1 - 8.2e-10 39.3 0.1 1.6e-09 38.3 0.1 1.5 1 0 0 1 1 1 1 NADH pyrophosphatase-like rudimentary NUDIX domain zf-NADH-PPase PF09297.11 ELR24060.1 - 7.2e-07 28.8 1.1 1.4e-06 27.8 1.1 1.5 1 0 0 1 1 1 1 NADH pyrophosphatase zinc ribbon domain V-SNARE PF05008.15 ELR24061.1 - 0.00017 21.9 0.1 0.00023 21.5 0.1 1.2 1 0 0 1 1 1 1 Vesicle transport v-SNARE protein N-terminus V-SNARE_C PF12352.8 ELR24062.1 - 1.4e-06 28.4 2.4 1.4e-06 28.4 2.4 3.0 3 0 0 3 3 3 1 Snare region anchored in the vesicle membrane C-terminus Sec20 PF03908.13 ELR24062.1 - 7.3e-05 22.6 8.2 0.00095 19.0 0.5 3.1 3 0 0 3 3 3 2 Sec20 V-SNARE PF05008.15 ELR24062.1 - 0.007 16.7 0.9 0.007 16.7 0.9 2.6 3 0 0 3 3 3 1 Vesicle transport v-SNARE protein N-terminus DUF2070 PF09843.9 ELR24062.1 - 0.12 10.7 16.6 0.15 10.3 16.6 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) CENP-F_leu_zip PF10473.9 ELR24062.1 - 0.92 9.5 8.6 5.7 7.0 0.1 2.8 2 1 1 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 OppC_N PF12911.7 ELR24062.1 - 2 8.4 7.2 8.1 6.5 7.2 2.0 1 0 0 1 1 1 0 N-terminal TM domain of oligopeptide transport permease C SlyX PF04102.12 ELR24062.1 - 2.6 8.7 8.4 4.5 7.9 0.3 2.7 3 0 0 3 3 3 0 SlyX Cnn_1N PF07989.11 ELR24062.1 - 4.6 7.5 8.7 11 6.3 0.6 3.1 3 0 0 3 3 3 0 Centrosomin N-terminal motif 1 HMA PF00403.26 ELR24063.1 - 2.8e-16 59.7 1.8 3.1e-16 59.6 1.8 1.0 1 0 0 1 1 1 1 Heavy-metal-associated domain Glutaredoxin PF00462.24 ELR24063.1 - 0.076 13.3 0.1 0.085 13.1 0.1 1.3 1 1 0 1 1 1 0 Glutaredoxin Med19 PF10278.9 ELR24064.1 - 8.1 6.3 10.5 0.97 9.3 1.3 2.3 2 0 0 2 2 2 0 Mediator of RNA pol II transcription subunit 19 NmrA PF05368.13 ELR24065.1 - 1.1e-09 38.2 0.0 1.4e-09 37.9 0.0 1.0 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 ELR24065.1 - 3.3e-07 30.4 0.0 3.9e-07 30.2 0.0 1.1 1 0 0 1 1 1 1 NAD(P)H-binding RCC1 PF00415.18 ELR24066.1 - 3.4e-53 178.1 16.2 1.4e-11 44.8 0.1 6.8 6 1 0 6 6 6 6 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 ELR24066.1 - 3.1e-28 97.0 21.3 3.6e-07 29.8 0.1 6.4 7 0 0 7 7 7 5 Regulator of chromosome condensation (RCC1) repeat SUKH-3 PF14433.6 ELR24066.1 - 0.012 16.1 0.2 8.1 6.9 0.0 3.3 2 1 0 3 3 3 0 SUKH-3 immunity protein F-box-like PF12937.7 ELR24066.1 - 0.14 12.1 0.0 0.33 10.9 0.0 1.6 1 0 0 1 1 1 0 F-box-like BCDHK_Adom3 PF10436.9 ELR24067.1 - 1.6e-47 161.3 0.4 2.3e-47 160.9 0.4 1.2 1 0 0 1 1 1 1 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase HATPase_c PF02518.26 ELR24067.1 - 6.2e-14 52.5 0.0 2.2e-13 50.7 0.0 1.8 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 ELR24067.1 - 0.0099 15.7 0.0 0.021 14.7 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DUF2719 PF10891.8 ELR24068.1 - 0.16 11.9 0.0 0.3 11.0 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2719) Oxysterol_BP PF01237.18 ELR24070.1 - 2.9e-44 151.4 0.0 4.4e-40 137.7 0.0 2.2 1 1 1 2 2 2 2 Oxysterol-binding protein K_channel_TID PF07941.11 ELR24070.1 - 0.048 14.1 4.3 0.12 12.8 4.3 1.6 1 0 0 1 1 1 0 Potassium channel Kv1.4 tandem inactivation domain DUF4813 PF16072.5 ELR24070.1 - 0.21 11.2 1.4 0.35 10.5 1.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4813) Abhydrolase_3 PF07859.13 ELR24071.1 - 5.9e-54 183.1 1.0 8.5e-54 182.6 1.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold COesterase PF00135.28 ELR24071.1 - 7e-12 45.0 0.0 1e-11 44.4 0.0 1.2 1 0 0 1 1 1 1 Carboxylesterase family Say1_Mug180 PF10340.9 ELR24071.1 - 0.0034 16.3 0.0 0.0052 15.7 0.0 1.2 1 0 0 1 1 1 1 Steryl acetyl hydrolase DLH PF01738.18 ELR24071.1 - 0.017 14.7 0.3 0.043 13.4 0.1 1.7 2 0 0 2 2 2 0 Dienelactone hydrolase family PX PF00787.24 ELR24073.1 - 8.6e-07 28.9 0.1 1.1e-06 28.6 0.1 1.1 1 0 0 1 1 1 1 PX domain DUF3787 PF12655.7 ELR24073.1 - 0.0015 18.4 0.4 0.0024 17.8 0.4 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3787) Amidohydro_2 PF04909.14 ELR24074.1 - 1.1e-23 84.5 2.0 1.4e-23 84.1 2.0 1.2 1 0 0 1 1 1 1 Amidohydrolase Pil1 PF13805.6 ELR24074.1 - 0.023 14.2 0.0 0.036 13.6 0.0 1.2 1 0 0 1 1 1 0 Eisosome component PIL1 MIP PF00230.20 ELR24075.1 - 3e-26 92.5 13.2 1.4e-22 80.6 9.2 2.1 1 1 1 2 2 2 2 Major intrinsic protein HRG PF16954.5 ELR24075.1 - 0.058 13.8 3.9 0.075 13.4 0.8 2.8 2 1 0 2 2 2 0 Haem-transporter, endosomal/lysosomal, haem-responsive gene 5TM-5TMR_LYT PF07694.12 ELR24075.1 - 0.99 8.9 15.3 0.92 9.0 9.6 2.6 1 1 1 2 2 2 0 5TMR of 5TMR-LYT EMP70 PF02990.16 ELR24075.1 - 8.7 4.9 7.1 13 4.3 7.1 1.4 1 0 0 1 1 1 0 Endomembrane protein 70 Glyco_hydro_15 PF00723.21 ELR24076.1 - 4.2e-145 484.0 0.0 5.3e-145 483.6 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 15 VCBS PF13517.6 ELR24077.1 - 1e-19 70.9 11.5 1.8e-07 31.7 3.4 4.8 5 0 0 5 5 5 3 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.23 ELR24077.1 - 1.6e-07 31.3 22.7 0.0014 18.7 1.1 5.8 5 0 0 5 5 5 3 FG-GAP repeat PQQ PF01011.21 ELR24077.1 - 1.7e-06 27.6 2.2 1.4 9.0 0.0 6.0 6 0 0 6 6 6 1 PQQ enzyme repeat PQQ_2 PF13360.6 ELR24077.1 - 1.9e-05 24.4 0.5 0.00024 20.8 0.1 2.9 3 1 0 3 3 3 1 PQQ-like domain BBS2_Mid PF14783.6 ELR24077.1 - 0.00028 20.9 0.5 2.2 8.3 0.0 4.6 4 1 0 4 4 4 2 Ciliary BBSome complex subunit 2, middle region PQQ_3 PF13570.6 ELR24077.1 - 0.0022 18.4 14.2 10 6.8 0.2 7.0 5 2 0 5 5 5 2 PQQ-like domain TcdB_toxin_midN PF12256.8 ELR24077.1 - 0.0025 17.2 6.1 2.5 7.4 0.0 4.4 4 1 1 5 5 5 2 Insecticide toxin TcdB middle/N-terminal region Itfg2 PF15907.5 ELR24077.1 - 2.7 6.9 7.1 26 3.7 0.1 4.1 4 1 0 4 4 4 0 Integrin-alpha FG-GAP repeat-containing protein 2 EF-hand_6 PF13405.6 ELR24077.1 - 7.6 6.8 5.6 8.6 6.6 0.0 3.1 3 0 0 3 3 3 0 EF-hand domain Sod_Cu PF00080.20 ELR24078.1 - 7.9e-43 146.0 3.5 1.2e-28 100.1 2.8 2.2 2 0 0 2 2 2 2 Copper/zinc superoxide dismutase (SODC) Exostosin PF03016.15 ELR24079.1 - 0.00064 19.0 0.0 0.001 18.3 0.0 1.2 1 0 0 1 1 1 1 Exostosin family Kinesin PF00225.23 ELR24080.1 - 4.6e-95 318.4 0.3 4.6e-95 318.4 0.3 2.9 4 0 0 4 4 4 1 Kinesin motor domain Microtub_bd PF16796.5 ELR24080.1 - 2.9e-19 69.5 0.0 8.6e-19 67.9 0.0 1.8 1 0 0 1 1 1 1 Microtubule binding HHH PF00633.23 ELR24080.1 - 8.2e-05 22.3 0.0 0.00027 20.6 0.0 1.9 1 0 0 1 1 1 1 Helix-hairpin-helix motif HHH_3 PF12836.7 ELR24080.1 - 0.00059 20.0 0.1 0.0026 18.0 0.0 2.1 2 0 0 2 2 2 1 Helix-hairpin-helix motif TPR_2 PF07719.17 ELR24080.1 - 0.0008 19.3 0.4 0.0019 18.1 0.4 1.6 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_1 PF00515.28 ELR24080.1 - 0.011 15.5 0.3 0.024 14.5 0.3 1.5 1 0 0 1 1 1 0 Tetratricopeptide repeat HHH_5 PF14520.6 ELR24080.1 - 0.037 14.6 0.0 0.14 12.7 0.0 2.0 1 0 0 1 1 1 0 Helix-hairpin-helix domain NHL PF01436.21 ELR24083.1 - 0.00048 20.0 0.3 0.002 18.1 0.1 2.1 2 0 0 2 2 2 1 NHL repeat EGF_alliinase PF04863.13 ELR24083.1 - 9.3 6.7 7.6 21 5.6 0.2 3.3 1 1 1 2 2 2 0 Alliinase EGF-like domain F-box-like PF12937.7 ELR24084.1 - 5.3e-09 35.8 0.1 2.1e-08 33.9 0.0 2.0 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 ELR24084.1 - 2.5e-06 27.2 0.0 4.8e-06 26.3 0.0 1.4 1 0 0 1 1 1 1 F-box domain GRDP-like PF07173.12 ELR24084.1 - 0.0011 19.7 3.8 0.004 17.8 1.6 2.4 3 0 0 3 3 3 1 Glycine-rich domain-containing protein-like Glyco_transf_41 PF13844.6 ELR24086.1 - 0.0082 14.6 1.1 0.01 14.3 1.1 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 41 CHASE6_C PF17150.4 ELR24086.1 - 0.041 14.5 1.7 0.096 13.4 0.5 2.3 2 0 0 2 2 2 0 C-terminal domain of two-partite extracellular sensor domain RNA_pol_Rpc4 PF05132.14 ELR24086.1 - 0.22 11.9 5.1 0.41 11.1 5.1 1.4 1 0 0 1 1 1 0 RNA polymerase III RPC4 D5_N PF08706.11 ELR24086.1 - 2.2 8.5 7.5 11 6.2 1.7 2.3 2 0 0 2 2 2 0 D5 N terminal like Vfa1 PF08432.10 ELR24086.1 - 2.4 8.5 17.5 0.11 12.9 11.0 1.9 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 RF-1 PF00472.20 ELR24086.1 - 2.4 8.1 14.4 0.31 11.0 9.3 2.2 2 1 0 2 2 2 0 RF-1 domain RCC1_2 PF13540.6 ELR24090.1 - 5.3e-23 80.3 39.7 1.9e-06 27.5 2.7 7.1 7 0 0 7 7 7 5 Regulator of chromosome condensation (RCC1) repeat His_Phos_1 PF00300.22 ELR24091.1 - 2.7e-20 72.9 0.0 1.6e-19 70.4 0.0 1.9 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) PIG-Y PF15159.6 ELR24091.1 - 0.12 13.3 1.7 0.55 11.2 0.0 2.3 2 1 0 2 2 2 0 Phosphatidylinositol N-acetylglucosaminyltransferase subunit Y C2 PF00168.30 ELR24092.1 - 6.1e-22 77.9 0.1 8.3e-22 77.4 0.1 1.2 1 0 0 1 1 1 1 C2 domain Response_reg PF00072.24 ELR24093.1 - 6.2e-23 81.1 0.0 1.2e-22 80.1 0.0 1.5 1 0 0 1 1 1 1 Response regulator receiver domain HATPase_c PF02518.26 ELR24093.1 - 1.5e-21 77.0 0.0 4e-21 75.6 0.0 1.8 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 ELR24093.1 - 0.0093 16.0 0.0 0.024 14.7 0.0 1.7 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain Mon1 PF03164.14 ELR24094.1 - 4.9e-15 55.5 0.3 2.2e-14 53.4 0.1 1.9 2 0 0 2 2 2 1 Trafficking protein Mon1 PG_binding_1 PF01471.18 ELR24094.1 - 2.5e-05 24.4 0.1 7.3e-05 22.9 0.0 1.9 2 0 0 2 2 2 1 Putative peptidoglycan binding domain Acetyltransf_16 PF05301.11 ELR24094.1 - 0.075 12.8 0.0 0.14 11.9 0.0 1.4 1 0 0 1 1 1 0 GNAT acetyltransferase, Mec-17 GRIM-19 PF06212.12 ELR24095.1 - 1.5e-11 44.3 0.4 2e-11 43.9 0.4 1.1 1 0 0 1 1 1 1 GRIM-19 protein UQ_con PF00179.26 ELR24096.1 - 7.8e-15 54.7 0.0 9.2e-15 54.5 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UEV PF05743.13 ELR24096.1 - 0.0021 17.9 0.0 0.0026 17.6 0.0 1.1 1 0 0 1 1 1 1 UEV domain Ldh_1_C PF02866.18 ELR24097.1 - 2.7e-29 102.2 0.0 4.7e-29 101.5 0.0 1.3 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Ldh_1_N PF00056.23 ELR24097.1 - 2e-22 79.8 0.0 4.7e-22 78.6 0.0 1.6 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain SET PF00856.28 ELR24098.1 - 1.5e-10 41.8 0.4 2e-09 38.1 0.4 2.0 1 1 0 1 1 1 1 SET domain SAF PF08666.12 ELR24098.1 - 0.001 19.6 0.0 0.5 11.0 0.0 2.4 2 0 0 2 2 2 2 SAF domain 7tm_2 PF00002.24 ELR24099.1 - 1.5e-08 34.3 15.4 2e-08 33.9 15.4 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) Dicty_CAR PF05462.11 ELR24099.1 - 5.8e-07 28.9 15.8 7.9e-07 28.5 15.8 1.1 1 0 0 1 1 1 1 Slime mold cyclic AMP receptor GPR_Gpa2_C PF11970.8 ELR24099.1 - 2.7e-05 24.1 0.2 8.4e-05 22.6 0.2 1.9 1 0 0 1 1 1 1 G protein-coupled glucose receptor regulating Gpa2 C-term 7tm_1 PF00001.21 ELR24099.1 - 0.00052 19.4 13.5 0.001 18.5 13.5 1.5 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srv PF10323.9 ELR24099.1 - 0.0026 17.2 0.3 0.0026 17.2 0.3 2.0 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srv DUF2157 PF09925.9 ELR24099.1 - 0.33 10.7 9.9 0.059 13.1 3.2 2.4 2 0 0 2 2 2 0 Predicted membrane protein (DUF2157) Cupin_5 PF06172.11 ELR24101.1 - 8.8e-08 32.4 0.0 1.3e-07 31.9 0.0 1.3 1 0 0 1 1 1 1 Cupin superfamily (DUF985) 7tm_2 PF00002.24 ELR24101.1 - 2e-07 30.6 13.1 2.6e-07 30.2 13.1 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) DUF2157 PF09925.9 ELR24101.1 - 0.28 11.0 8.0 0.052 13.3 3.9 1.8 2 0 0 2 2 2 0 Predicted membrane protein (DUF2157) 7tm_1 PF00001.21 ELR24101.1 - 1.4 8.2 9.4 2.8 7.2 9.4 1.5 1 1 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) DUF5644 PF18712.1 ELR24103.1 - 0.0054 16.7 0.0 0.012 15.6 0.0 1.6 1 0 0 1 1 1 1 Family of unknown function (DUF5644) Methyltransf_24 PF13578.6 ELR24104.1 - 0.0056 17.7 0.2 0.017 16.1 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Cons_hypoth95 PF03602.15 ELR24104.1 - 0.11 12.1 0.2 0.52 9.9 0.2 2.0 1 1 0 1 1 1 0 Conserved hypothetical protein 95 Pyr_redox_2 PF07992.14 ELR24105.1 - 6e-58 196.4 0.2 7.8e-58 196.0 0.2 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.22 ELR24105.1 - 3.8e-29 101.1 0.0 6.8e-29 100.3 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.27 ELR24105.1 - 6.9e-18 65.0 3.5 8.6e-15 55.1 0.1 2.9 3 0 0 3 3 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 ELR24105.1 - 7.7e-11 41.8 0.0 1.1e-07 31.4 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 ELR24105.1 - 1.8e-06 27.3 4.8 2.2e-05 23.8 2.1 2.5 2 1 0 3 3 3 1 FAD binding domain FAD_oxidored PF12831.7 ELR24105.1 - 9.8e-06 25.2 0.1 1.5e-05 24.6 0.1 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase AlaDh_PNT_C PF01262.21 ELR24105.1 - 1e-05 24.9 0.1 0.0025 17.1 0.0 2.3 2 0 0 2 2 2 2 Alanine dehydrogenase/PNT, C-terminal domain GIDA PF01134.22 ELR24105.1 - 0.00014 21.1 0.6 0.00024 20.3 0.6 1.3 1 0 0 1 1 1 1 Glucose inhibited division protein A HI0933_like PF03486.14 ELR24105.1 - 0.00032 19.5 1.0 0.0019 17.0 0.4 2.3 3 0 0 3 3 3 1 HI0933-like protein Thi4 PF01946.17 ELR24105.1 - 0.00094 18.5 0.1 0.0018 17.6 0.1 1.4 1 0 0 1 1 1 1 Thi4 family DAO PF01266.24 ELR24105.1 - 0.15 11.6 4.0 0.36 10.4 4.0 1.9 1 1 0 1 1 1 0 FAD dependent oxidoreductase Lycopene_cycl PF05834.12 ELR24105.1 - 0.33 10.0 1.5 0.58 9.1 1.5 1.5 1 1 0 1 1 1 0 Lycopene cyclase protein NAD_binding_8 PF13450.6 ELR24105.1 - 0.79 10.0 6.7 0.075 13.3 1.4 2.0 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain NUDE_C PF04880.13 ELR24106.1 - 0.019 15.5 8.7 0.023 15.2 8.7 1.3 1 0 0 1 1 1 0 NUDE protein, C-terminal conserved region NCOA_u2 PF16665.5 ELR24106.1 - 0.023 15.0 3.1 0.023 15.0 3.1 2.1 1 1 1 2 2 2 0 Unstructured region on nuclear receptor coactivator protein RasGAP PF00616.19 ELR24107.1 - 4.4e-10 39.6 1.0 2.8e-09 37.0 0.0 2.6 3 0 0 3 3 3 1 GTPase-activator protein for Ras-like GTPase DUF5601 PF18151.1 ELR24107.1 - 5.2e-05 23.5 0.1 0.00017 21.8 0.1 2.0 1 0 0 1 1 1 1 Domain of unknown function (DUF5601) VPS9 PF02204.18 ELR24107.1 - 0.00067 19.8 0.0 0.0018 18.4 0.0 1.8 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain CDC45 PF02724.14 ELR24107.1 - 0.021 13.1 0.6 0.031 12.6 0.6 1.2 1 0 0 1 1 1 0 CDC45-like protein DnaJ PF00226.31 ELR24108.1 - 5.1e-15 55.3 0.3 5.1e-15 55.3 0.3 2.5 2 0 0 2 2 2 1 DnaJ domain Fe-S_biosyn PF01521.20 ELR24110.1 - 4.8e-14 52.5 0.0 8.1e-14 51.8 0.0 1.4 1 0 0 1 1 1 1 Iron-sulphur cluster biosynthesis IBR PF01485.21 ELR24111.1 - 1.1e-16 60.8 8.7 1.1e-16 60.8 8.7 4.3 3 1 1 4 4 4 2 IBR domain, a half RING-finger domain GAT PF03127.14 ELR24111.1 - 0.00088 19.5 0.8 0.0015 18.8 0.0 1.9 2 0 0 2 2 2 1 GAT domain zf-RING_UBOX PF13445.6 ELR24111.1 - 0.0022 17.9 4.6 0.0022 17.9 4.6 2.6 3 0 0 3 3 3 1 RING-type zinc-finger BUD22 PF09073.10 ELR24111.1 - 0.0066 15.8 3.6 0.0066 15.8 3.6 1.5 2 0 0 2 2 2 1 BUD22 CDC45 PF02724.14 ELR24111.1 - 0.095 11.0 7.8 0.14 10.4 7.8 1.2 1 0 0 1 1 1 0 CDC45-like protein Nop14 PF04147.12 ELR24111.1 - 2.4 6.3 16.0 4.6 5.3 16.0 1.4 1 0 0 1 1 1 0 Nop14-like family zf-RING_14 PF17978.1 ELR24111.1 - 3 8.3 7.7 0.57 10.6 0.5 2.5 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain Cytomega_UL84 PF06284.11 ELR24111.1 - 5.9 5.2 6.7 8.3 4.7 6.7 1.1 1 0 0 1 1 1 0 Cytomegalovirus UL84 protein RNA_pol_3_Rpc31 PF11705.8 ELR24111.1 - 7.9 6.7 16.3 16 5.7 16.3 1.4 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 zf-C3HC4_3 PF13920.6 ELR24111.1 - 8 6.4 25.9 0.17 11.7 4.7 3.4 3 0 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) UAA PF08449.11 ELR24112.1 - 5.3e-48 163.8 20.1 6.1e-48 163.6 20.1 1.0 1 0 0 1 1 1 1 UAA transporter family EamA PF00892.20 ELR24112.1 - 2e-06 28.0 23.1 0.00027 21.1 12.1 2.2 2 0 0 2 2 2 2 EamA-like transporter family FUSC_2 PF13515.6 ELR24115.1 - 0.00017 21.7 22.3 0.02 15.0 10.4 3.0 2 1 0 2 2 2 2 Fusaric acid resistance protein-like COG2 PF06148.11 ELR24115.1 - 0.021 14.9 0.1 0.044 13.9 0.1 1.5 1 0 0 1 1 1 0 COG (conserved oligomeric Golgi) complex component, COG2 Tropomyosin_1 PF12718.7 ELR24115.1 - 0.11 12.7 0.3 0.17 12.0 0.3 1.2 1 0 0 1 1 1 0 Tropomyosin like ParE_toxin PF05016.15 ELR24115.1 - 0.13 12.8 2.9 9.9 6.9 0.0 2.7 2 0 0 2 2 2 0 ParE toxin of type II toxin-antitoxin system, parDE F-box-like PF12937.7 ELR24116.1 - 6.2e-09 35.6 0.7 1.2e-08 34.7 0.7 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ELR24116.1 - 8.5e-08 31.9 0.1 1.6e-07 31.0 0.1 1.5 1 0 0 1 1 1 1 F-box domain PRANC PF09372.10 ELR24116.1 - 0.031 14.6 0.0 0.046 14.0 0.0 1.3 1 0 0 1 1 1 0 PRANC domain F-box-like_2 PF13013.6 ELR24116.1 - 0.098 12.6 0.5 0.29 11.1 0.3 1.8 1 1 0 1 1 1 0 F-box-like domain LRR19-TM PF15176.6 ELR24116.1 - 0.15 12.0 1.0 0.32 11.0 1.0 1.7 1 0 0 1 1 1 0 Leucine-rich repeat family 19 TM domain Cyt-b5 PF00173.28 ELR24118.1 - 7.1e-24 83.7 0.0 8.9e-24 83.4 0.0 1.1 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain tRNA_anti-codon PF01336.25 ELR24118.1 - 0.038 14.0 0.0 0.065 13.2 0.0 1.4 1 1 0 1 1 1 0 OB-fold nucleic acid binding domain CDC45 PF02724.14 ELR24119.1 - 0.34 9.1 4.7 0.45 8.8 4.7 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF2457 PF10446.9 ELR24119.1 - 0.38 9.9 12.2 0.57 9.3 12.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Nop14 PF04147.12 ELR24119.1 - 1.6 6.9 11.3 2.7 6.1 11.3 1.3 1 0 0 1 1 1 0 Nop14-like family DEP PF00610.21 ELR24120.1 - 1.1e-07 31.7 0.0 2.2e-07 30.8 0.0 1.4 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) adh_short PF00106.25 ELR24121.1 - 1.8e-15 56.9 0.0 6.2e-12 45.4 0.0 2.7 2 1 0 2 2 2 2 short chain dehydrogenase KR PF08659.10 ELR24121.1 - 1e-05 25.5 0.1 1.5e-05 25.0 0.1 1.2 1 0 0 1 1 1 1 KR domain Eno-Rase_NADH_b PF12242.8 ELR24121.1 - 0.048 13.4 0.0 0.097 12.4 0.0 1.5 1 0 0 1 1 1 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase PRMT5 PF05185.16 ELR24121.1 - 0.055 13.3 0.0 0.16 11.8 0.0 1.7 2 0 0 2 2 2 0 PRMT5 arginine-N-methyltransferase DUF2347 PF09804.9 ELR24122.1 - 6.9e-60 203.0 0.2 8.9e-60 202.7 0.2 1.1 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2347) SPA PF08616.10 ELR24122.1 - 1.2e-11 44.6 0.4 2.5e-11 43.5 0.4 1.4 1 0 0 1 1 1 1 Stabilization of polarity axis Avl9 PF09794.9 ELR24122.1 - 1.3e-08 34.0 0.2 3.7e-05 22.6 0.0 3.1 1 1 1 2 2 2 2 Transport protein Avl9 SAM_1 PF00536.30 ELR24123.1 - 4.1e-07 30.3 0.0 6.9e-07 29.6 0.0 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 ELR24123.1 - 7.4e-07 29.2 0.0 1.5e-06 28.2 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) NinG PF05766.12 ELR24123.1 - 0.011 15.6 7.8 0.018 15.0 7.8 1.3 1 0 0 1 1 1 0 Bacteriophage Lambda NinG protein SIR2 PF02146.17 ELR24124.1 - 2.1e-29 102.7 5.0 5.3e-22 78.6 0.1 3.3 2 1 1 3 3 3 2 Sir2 family zf-UBP PF02148.19 ELR24124.1 - 1.1e-16 60.9 11.2 1.1e-16 60.9 11.2 3.2 3 0 0 3 3 3 1 Zn-finger in ubiquitin-hydrolases and other protein C1_2 PF03107.16 ELR24124.1 - 1.3e-08 35.0 6.9 1.3e-08 35.0 6.9 4.5 4 0 0 4 4 4 1 C1 domain TPP_enzyme_M PF00205.22 ELR24124.1 - 0.0089 15.8 0.0 1 9.1 0.0 2.3 2 0 0 2 2 2 2 Thiamine pyrophosphate enzyme, central domain Aminotran_5 PF00266.19 ELR24125.1 - 9.5e-26 90.6 0.0 1.3e-25 90.1 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-V Aminotran_1_2 PF00155.21 ELR24125.1 - 4.9e-06 25.9 0.0 7.7e-06 25.3 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.20 ELR24125.1 - 0.00049 18.7 0.0 0.00072 18.2 0.0 1.1 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme DegT_DnrJ_EryC1 PF01041.17 ELR24125.1 - 0.0055 16.1 0.2 0.013 14.8 0.1 1.6 2 0 0 2 2 2 1 DegT/DnrJ/EryC1/StrS aminotransferase family Methyltransf_16 PF10294.9 ELR24126.1 - 6.4e-23 81.4 0.0 1.3e-22 80.3 0.0 1.4 1 1 0 1 1 1 1 Lysine methyltransferase CUB PF00431.20 ELR24127.1 - 1.7e-28 99.2 0.0 8.3e-09 35.8 0.0 4.1 4 0 0 4 4 4 3 CUB domain EGF_2 PF07974.13 ELR24127.1 - 1.9e-12 47.3 107.5 0.0036 17.7 9.5 6.6 6 0 0 6 6 6 6 EGF-like domain EGF PF00008.27 ELR24127.1 - 0.00097 19.4 19.7 0.0023 18.2 4.2 6.6 6 0 0 6 6 6 2 EGF-like domain hEGF PF12661.7 ELR24127.1 - 0.1 13.3 78.4 0.19 12.4 4.0 7.4 6 0 0 6 6 6 0 Human growth factor-like EGF TPR_12 PF13424.6 ELR24129.1 - 0.0041 17.4 0.8 0.0041 17.4 0.8 2.3 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_16 PF13432.6 ELR24129.1 - 0.0065 17.1 1.4 0.0065 17.1 1.4 3.1 3 0 0 3 3 3 1 Tetratricopeptide repeat Sel1 PF08238.12 ELR24129.1 - 0.74 10.6 5.6 13 6.7 0.9 3.2 3 0 0 3 3 3 0 Sel1 repeat TPR_2 PF07719.17 ELR24129.1 - 1.5 9.1 7.8 15 6.0 0.5 3.6 4 0 0 4 4 4 0 Tetratricopeptide repeat PseudoU_synth_1 PF01416.20 ELR24130.1 - 2e-29 102.2 0.0 2.2e-27 95.7 0.0 2.8 2 0 0 2 2 2 2 tRNA pseudouridine synthase Arrestin_C PF02752.22 ELR24131.1 - 1.1e-05 25.9 0.2 1.1e-05 25.9 0.2 2.3 2 1 0 2 2 2 1 Arrestin (or S-antigen), C-terminal domain DUF2393 PF09624.10 ELR24131.1 - 0.69 9.9 10.4 0.41 10.6 2.1 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF2393) SR-25 PF10500.9 ELR24131.1 - 2.5 7.7 43.8 0.098 12.3 30.6 2.1 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein DUF1115 PF06544.12 ELR24132.1 - 4.8e-12 46.2 0.0 1.6e-11 44.5 0.0 1.8 1 1 0 1 1 1 1 Protein of unknown function (DUF1115) SpoIID PF08486.10 ELR24132.1 - 0.057 14.0 0.1 0.11 13.1 0.1 1.5 1 0 0 1 1 1 0 Stage II sporulation protein OTU PF02338.19 ELR24133.1 - 5.6e-12 46.3 0.0 1.1e-11 45.3 0.0 1.5 1 0 0 1 1 1 1 OTU-like cysteine protease CDPS PF16715.5 ELR24133.1 - 0.088 12.4 1.3 1.2 8.7 0.2 2.3 2 0 0 2 2 2 0 Cyclodipeptide synthase ASFV_J13L PF05568.11 ELR24133.1 - 0.14 11.9 2.4 0.61 9.8 2.4 1.9 1 1 0 1 1 1 0 African swine fever virus J13L protein GCV_T PF01571.21 ELR24134.1 - 1e-68 231.5 0.0 1.6e-68 230.9 0.0 1.2 1 0 0 1 1 1 1 Aminomethyltransferase folate-binding domain DAO PF01266.24 ELR24134.1 - 1.2e-58 199.4 0.2 1.9e-58 198.7 0.2 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase GCV_T_C PF08669.11 ELR24134.1 - 8.2e-25 86.5 0.1 1.6e-24 85.6 0.1 1.5 1 0 0 1 1 1 1 Glycine cleavage T-protein C-terminal barrel domain FAO_M PF16350.5 ELR24134.1 - 5e-13 49.2 0.1 1e-12 48.2 0.1 1.5 1 0 0 1 1 1 1 FAD dependent oxidoreductase central domain Pyr_redox_2 PF07992.14 ELR24134.1 - 7.1e-06 25.5 0.4 0.087 12.0 0.0 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 ELR24134.1 - 7.5e-06 25.4 1.0 0.012 14.9 0.2 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 ELR24134.1 - 3.6e-05 24.2 2.0 0.2 12.2 0.0 2.6 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase SoxG PF04268.12 ELR24134.1 - 4.2e-05 23.7 0.0 0.00068 19.8 0.0 2.3 1 1 1 2 2 2 1 Sarcosine oxidase, gamma subunit family NAD_binding_8 PF13450.6 ELR24134.1 - 0.0092 16.2 0.4 0.05 13.8 0.4 2.4 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain GMC_oxred_N PF00732.19 ELR24134.1 - 0.011 15.2 0.2 0.62 9.4 0.0 2.2 2 0 0 2 2 2 0 GMC oxidoreductase FAD_binding_3 PF01494.19 ELR24134.1 - 0.012 14.8 2.3 0.26 10.5 0.0 2.3 2 0 0 2 2 2 0 FAD binding domain FAD_binding_2 PF00890.24 ELR24134.1 - 0.035 13.2 3.9 0.089 11.9 3.8 1.6 1 1 0 1 1 1 0 FAD binding domain NAD_binding_9 PF13454.6 ELR24134.1 - 0.037 14.0 1.1 0.26 11.3 0.2 2.7 3 0 0 3 3 3 0 FAD-NAD(P)-binding HI0933_like PF03486.14 ELR24134.1 - 0.039 12.6 0.1 0.039 12.6 0.1 1.9 2 0 0 2 2 2 0 HI0933-like protein Trp_halogenase PF04820.14 ELR24134.1 - 1.3 7.8 5.1 2.7 6.7 0.2 2.2 2 0 0 2 2 2 0 Tryptophan halogenase Pterin_4a PF01329.19 ELR24135.1 - 1.8e-29 101.7 0.5 2.3e-29 101.4 0.5 1.1 1 0 0 1 1 1 1 Pterin 4 alpha carbinolamine dehydratase RNase_P_p30 PF01876.16 ELR24135.1 - 0.005 16.3 0.0 0.0061 16.0 0.0 1.1 1 0 0 1 1 1 1 RNase P subunit p30 DAD PF02109.16 ELR24136.1 - 2.2e-45 153.4 2.8 2.5e-45 153.3 2.8 1.0 1 0 0 1 1 1 1 DAD family RETICULATA-like PF11891.8 ELR24136.1 - 0.025 14.4 0.1 0.038 13.8 0.0 1.4 1 1 0 1 1 1 0 Protein RETICULATA-related E1-E2_ATPase PF00122.20 ELR24136.1 - 0.082 12.4 0.3 0.1 12.1 0.3 1.1 1 0 0 1 1 1 0 E1-E2 ATPase DUF2207 PF09972.9 ELR24136.1 - 0.33 9.7 1.2 0.33 9.7 1.2 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) WD40 PF00400.32 ELR24137.1 - 5.7e-34 115.6 18.5 1.1e-07 32.4 0.3 7.3 7 0 0 7 7 7 5 WD domain, G-beta repeat F-box-like PF12937.7 ELR24137.1 - 3.4e-09 36.5 0.0 6.8e-09 35.5 0.0 1.6 1 0 0 1 1 1 1 F-box-like ANAPC4_WD40 PF12894.7 ELR24137.1 - 5.5e-08 33.0 1.1 0.41 11.0 0.0 4.7 1 1 3 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain PQQ_2 PF13360.6 ELR24137.1 - 7.9e-07 28.9 1.0 7.4e-05 22.4 0.1 2.7 1 1 0 2 2 2 1 PQQ-like domain PQQ_3 PF13570.6 ELR24137.1 - 3.2e-05 24.3 0.0 5.5 7.6 0.0 5.2 5 0 0 5 5 5 1 PQQ-like domain F-box PF00646.33 ELR24137.1 - 0.00025 20.9 0.0 0.00048 19.9 0.0 1.5 1 0 0 1 1 1 1 F-box domain WD40_like PF17005.5 ELR24137.1 - 0.0059 16.0 0.2 0.68 9.2 0.0 2.5 3 0 0 3 3 3 1 WD40-like domain PQQ PF01011.21 ELR24137.1 - 0.009 15.9 0.0 2 8.5 0.0 3.0 2 0 0 2 2 2 1 PQQ enzyme repeat Nup160 PF11715.8 ELR24137.1 - 0.074 11.7 8.5 7.5 5.1 0.0 4.5 4 2 1 5 5 5 0 Nucleoporin Nup120/160 Reg_prop PF07494.11 ELR24137.1 - 0.076 13.3 0.1 6.1 7.4 0.0 3.8 4 0 0 4 4 4 0 Two component regulator propeller Hira PF07569.11 ELR24137.1 - 0.33 10.6 2.1 0.9 9.2 0.1 2.6 2 1 0 3 3 3 0 TUP1-like enhancer of split Ribosomal_60s PF00428.19 ELR24138.1 - 0.028 15.0 4.4 0.059 14.0 4.4 1.6 1 0 0 1 1 1 0 60s Acidic ribosomal protein KSHV_K8 PF07188.11 ELR24138.1 - 0.13 11.6 0.0 0.23 10.8 0.0 1.3 1 0 0 1 1 1 0 Kaposi's sarcoma-associated herpesvirus (KSHV) K8 protein SNF2_N PF00176.23 ELR24140.1 - 1.9e-67 227.4 0.3 7.6e-67 225.5 0.3 1.9 1 1 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 ELR24140.1 - 7.6e-16 58.4 0.0 1.4e-15 57.5 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain zf-C3HC4_2 PF13923.6 ELR24140.1 - 2.8e-10 39.9 2.3 8.1e-10 38.4 1.7 2.2 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 ELR24140.1 - 5e-10 39.1 1.2 1.3e-09 37.7 1.2 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) ResIII PF04851.15 ELR24140.1 - 2.4e-09 37.4 0.0 5.1e-09 36.4 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit zf-RING_UBOX PF13445.6 ELR24140.1 - 5.6e-09 35.9 2.6 1.7e-08 34.4 2.6 1.9 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_4 PF15227.6 ELR24140.1 - 8.9e-07 29.0 3.5 2.1e-06 27.7 3.5 1.6 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_2 PF13639.6 ELR24140.1 - 1.6e-06 28.3 5.0 1.6e-06 28.3 5.0 2.1 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_3 PF13920.6 ELR24140.1 - 2.7e-06 27.1 4.2 5.6e-06 26.1 4.2 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ELR24140.1 - 2.7e-05 24.0 5.3 6.8e-05 22.7 5.3 1.7 1 0 0 1 1 1 1 zinc-RING finger domain Prok-RING_4 PF14447.6 ELR24140.1 - 0.00045 20.0 5.0 0.0018 18.1 5.2 2.0 1 1 1 2 2 2 1 Prokaryotic RING finger family 4 zf-Nse PF11789.8 ELR24140.1 - 0.0086 15.9 0.9 0.024 14.4 0.9 1.8 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_4 PF14570.6 ELR24140.1 - 0.077 12.8 6.5 0.19 11.5 6.5 1.7 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-rbx1 PF12678.7 ELR24140.1 - 0.15 12.4 3.3 0.42 10.9 2.4 2.3 1 1 0 1 1 1 0 RING-H2 zinc finger domain zf-RING_6 PF14835.6 ELR24140.1 - 0.32 10.9 1.1 0.8 9.6 1.1 1.6 1 0 0 1 1 1 0 zf-RING of BARD1-type protein RFX_DNA_binding PF02257.15 ELR24141.1 - 3.5e-10 40.3 0.5 6.3e-10 39.5 0.5 1.4 1 0 0 1 1 1 1 RFX DNA-binding domain NuDC PF16273.5 ELR24141.1 - 0.73 10.4 5.9 0.13 12.8 0.8 2.3 1 1 1 2 2 2 0 Nuclear distribution C domain PRiA4_ORF3 PF07929.11 ELR24142.1 - 3.1e-17 62.8 0.0 6.3e-17 61.8 0.0 1.4 1 0 0 1 1 1 1 Plasmid pRiA4b ORF-3-like protein Peptidase_S74 PF13884.6 ELR24143.1 - 3.9e-11 43.1 0.1 1.1e-10 41.7 0.1 1.8 1 0 0 1 1 1 1 Chaperone of endosialidase PhoLip_ATPase_N PF16209.5 ELR24145.1 - 6.7e-20 70.6 1.8 1.6e-19 69.4 0.3 2.2 2 0 0 2 2 2 1 Phospholipid-translocating ATPase N-terminal E1-E2_ATPase PF00122.20 ELR24145.1 - 5.5e-07 29.3 3.9 5.6e-07 29.3 0.0 2.6 3 0 0 3 3 3 1 E1-E2 ATPase Erv26 PF04148.13 ELR24145.1 - 0.015 15.2 0.1 0.015 15.2 0.1 2.1 2 0 0 2 2 2 0 Transmembrane adaptor Erv26 Sad1_UNC PF07738.13 ELR24146.1 - 1.4e-30 106.0 0.2 2.1e-30 105.4 0.2 1.3 1 0 0 1 1 1 1 Sad1 / UNC-like C-terminal Spt20 PF12090.8 ELR24146.1 - 0.0028 17.3 13.5 0.0054 16.4 13.5 1.5 1 0 0 1 1 1 1 Spt20 family TFIIA PF03153.13 ELR24146.1 - 0.0037 17.3 18.1 0.0037 17.3 18.1 1.4 2 0 0 2 2 2 1 Transcription factor IIA, alpha/beta subunit F5_F8_type_C PF00754.25 ELR24146.1 - 0.012 15.8 0.0 0.034 14.3 0.0 1.8 1 1 0 1 1 1 0 F5/8 type C domain PAT1 PF09770.9 ELR24146.1 - 0.32 9.2 11.7 0.46 8.7 11.7 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Hamartin PF04388.12 ELR24146.1 - 0.57 8.8 8.3 0.83 8.2 8.3 1.3 1 0 0 1 1 1 0 Hamartin protein Lin-8 PF03353.15 ELR24146.1 - 0.84 9.1 7.2 1.4 8.4 7.2 1.3 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist DUF4661 PF15576.6 ELR24146.1 - 1 9.2 5.2 1.7 8.5 5.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4661) Roughex PF06020.11 ELR24146.1 - 1.1 8.3 13.0 1.7 7.7 13.0 1.3 1 0 0 1 1 1 0 Drosophila roughex protein RR_TM4-6 PF06459.12 ELR24146.1 - 1.4 8.7 11.1 2.7 7.7 11.1 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF4045 PF13254.6 ELR24146.1 - 4.2 6.9 24.3 0.37 10.4 17.7 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4045) DUF4106 PF13388.6 ELR24146.1 - 4.2 6.5 18.7 7.1 5.7 18.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4106) Neur_chan_memb PF02932.16 ELR24146.1 - 5.1 7.1 6.8 1 9.4 3.5 1.5 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region Hid1 PF12722.7 ELR24146.1 - 6.8 4.7 8.0 9.6 4.2 8.0 1.2 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Presenilin PF01080.17 ELR24146.1 - 7.5 5.2 11.7 12 4.6 11.7 1.3 1 0 0 1 1 1 0 Presenilin DLIC PF05783.11 ELR24146.1 - 7.8 5.2 9.0 12 4.6 9.0 1.4 1 0 0 1 1 1 0 Dynein light intermediate chain (DLIC) Carn_acyltransf PF00755.20 ELR24147.1 - 1.4e-86 291.4 0.0 5.3e-86 289.5 0.0 1.7 1 1 1 2 2 2 2 Choline/Carnitine o-acyltransferase DUF778 PF05608.12 ELR24148.1 - 8.1e-25 88.3 5.9 5.5e-13 49.7 1.5 2.1 1 1 1 2 2 2 2 Protein of unknown function (DUF778) DEAD PF00270.29 ELR24149.1 - 1.9e-44 151.5 0.0 4.7e-44 150.2 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ELR24149.1 - 1e-20 74.1 0.0 5.8e-20 71.7 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DBP10CT PF08147.12 ELR24149.1 - 1.3e-13 50.9 8.3 3.6e-13 49.5 8.3 1.8 1 0 0 1 1 1 1 DBP10CT (NUC160) domain ResIII PF04851.15 ELR24149.1 - 6.9e-08 32.7 0.8 6e-07 29.6 0.0 2.5 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit GHMP_kinases_N PF00288.26 ELR24149.1 - 0.49 10.7 4.5 1.4 9.2 4.5 1.7 1 0 0 1 1 1 0 GHMP kinases N terminal domain DUF3138 PF11336.8 ELR24149.1 - 2.8 6.4 8.1 4.7 5.7 8.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) Aldedh PF00171.22 ELR24150.1 - 2.6e-150 501.0 0.6 1.3e-148 495.3 0.6 2.0 1 1 0 1 1 1 1 Aldehyde dehydrogenase family Branch PF02485.21 ELR24151.1 - 3.6e-19 69.3 0.0 4.9e-19 68.8 0.0 1.2 1 0 0 1 1 1 1 Core-2/I-Branching enzyme Thiolase_N PF00108.23 ELR24152.1 - 1.5e-92 309.7 2.6 1.5e-92 309.7 2.6 1.6 2 0 0 2 2 2 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 ELR24152.1 - 1.3e-43 147.6 0.3 1.3e-43 147.6 0.3 2.5 2 1 1 3 3 3 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.26 ELR24152.1 - 0.00087 18.9 5.5 0.00087 18.9 5.5 2.5 3 0 0 3 3 3 1 Beta-ketoacyl synthase, N-terminal domain HTH_8 PF02954.19 ELR24152.1 - 0.26 11.1 1.6 1.9 8.3 0.2 2.7 2 0 0 2 2 2 0 Bacterial regulatory protein, Fis family Aldedh PF00171.22 ELR24153.1 - 3.8e-150 500.4 0.6 1.1e-148 495.6 0.6 2.0 1 1 0 1 1 1 1 Aldehyde dehydrogenase family Branch PF02485.21 ELR24154.1 - 1.2e-18 67.6 0.0 1.6e-18 67.2 0.0 1.2 1 0 0 1 1 1 1 Core-2/I-Branching enzyme Thiolase_N PF00108.23 ELR24155.1 - 6.3e-92 307.6 2.6 6.3e-92 307.6 2.6 1.6 2 0 0 2 2 2 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 ELR24155.1 - 1.3e-43 147.6 0.3 1.3e-43 147.6 0.3 2.3 2 1 1 3 3 3 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.26 ELR24155.1 - 0.0016 18.1 5.7 0.0016 18.1 5.7 2.5 3 0 0 3 3 3 1 Beta-ketoacyl synthase, N-terminal domain F-box-like PF12937.7 ELR24156.1 - 2.8e-09 36.7 0.1 8.1e-09 35.2 0.0 1.9 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 ELR24156.1 - 0.0004 20.2 0.0 0.00092 19.0 0.0 1.7 1 0 0 1 1 1 1 F-box domain Aa_trans PF01490.18 ELR24157.1 - 5.7e-64 216.3 25.0 8.3e-64 215.8 25.0 1.2 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein AAA_18 PF13238.6 ELR24157.1 - 0.15 12.6 0.0 0.28 11.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain YycC PF14174.6 ELR24157.1 - 0.2 11.5 0.5 0.34 10.7 0.5 1.3 1 0 0 1 1 1 0 YycC-like protein DUF4448 PF14610.6 ELR24158.1 - 0.095 12.5 0.0 0.18 11.6 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4448) Usp PF00582.26 ELR24159.1 - 3e-08 34.3 0.3 1.8e-07 31.8 0.3 2.1 1 1 0 1 1 1 1 Universal stress protein family Kelch_6 PF13964.6 ELR24160.1 - 1.2e-13 50.7 5.3 0.011 16.0 0.0 5.9 6 0 0 6 6 6 4 Kelch motif Kelch_2 PF07646.15 ELR24160.1 - 1.8e-13 49.9 3.5 0.0015 18.4 0.0 5.8 6 0 0 6 6 6 3 Kelch motif Kelch_1 PF01344.25 ELR24160.1 - 7.8e-10 38.2 7.8 0.0036 16.9 0.0 6.2 7 0 0 7 7 7 2 Kelch motif Kelch_4 PF13418.6 ELR24160.1 - 4.7e-09 36.1 6.9 0.096 12.7 0.1 5.2 5 1 0 5 5 5 4 Galactose oxidase, central domain Kelch_3 PF13415.6 ELR24160.1 - 4.9e-09 36.2 6.0 7.3e-05 22.9 0.2 4.4 4 0 0 4 4 4 2 Galactose oxidase, central domain Kelch_5 PF13854.6 ELR24160.1 - 7.7e-06 25.8 7.4 0.00063 19.7 0.0 4.8 5 0 0 5 5 5 2 Kelch motif BCAS2 PF05700.11 ELR24162.1 - 6.2e-50 169.8 0.5 6.2e-50 169.8 0.5 1.9 1 1 1 2 2 2 1 Breast carcinoma amplified sequence 2 (BCAS2) NUC153 PF08159.12 ELR24163.1 - 3.3e-08 33.2 0.2 6.4e-08 32.3 0.2 1.4 1 0 0 1 1 1 1 NUC153 domain ANAPC4_WD40 PF12894.7 ELR24163.1 - 0.015 15.5 0.0 0.28 11.5 0.0 2.6 2 1 1 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain VWA_2 PF13519.6 ELR24164.1 - 1.7e-12 47.9 0.4 1.2e-11 45.2 0.1 2.4 1 1 1 2 2 2 1 von Willebrand factor type A domain UIM PF02809.20 ELR24164.1 - 3.8e-05 23.3 11.8 0.021 14.7 0.4 2.7 2 0 0 2 2 2 2 Ubiquitin interaction motif Ssl1 PF04056.14 ELR24164.1 - 0.013 15.4 0.1 0.019 14.8 0.1 1.3 1 0 0 1 1 1 0 Ssl1-like VWA PF00092.28 ELR24164.1 - 0.014 15.7 0.4 0.023 15.0 0.4 1.3 1 0 0 1 1 1 0 von Willebrand factor type A domain 6PF2K PF01591.18 ELR24164.1 - 0.035 13.4 0.1 0.05 12.9 0.1 1.1 1 0 0 1 1 1 0 6-phosphofructo-2-kinase tRNA_NucTran2_2 PF13735.6 ELR24164.1 - 0.056 13.4 1.6 0.13 12.3 0.0 2.2 2 1 1 3 3 3 0 tRNA nucleotidyltransferase domain 2 putative DEC-1_N PF04625.13 ELR24164.1 - 0.072 12.1 6.8 0.56 9.2 6.9 2.1 2 0 0 2 2 2 0 DEC-1 protein, N-terminal region MSA-2c PF12238.8 ELR24164.1 - 1.6 8.7 5.9 5.6 6.9 5.2 2.1 2 0 0 2 2 2 0 Merozoite surface antigen 2c PHF5 PF03660.14 ELR24165.1 - 2.2e-50 169.2 12.1 2.4e-50 169.1 12.1 1.0 1 0 0 1 1 1 1 PHF5-like protein zn-ribbon_14 PF16503.5 ELR24165.1 - 0.017 14.6 0.5 0.017 14.6 0.5 3.8 4 0 0 4 4 4 0 Zinc-ribbon PolC_DP2 PF03833.13 ELR24165.1 - 0.076 10.9 7.4 0.079 10.8 7.4 1.1 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 C1_2 PF03107.16 ELR24165.1 - 0.1 13.0 2.1 0.1 13.0 2.1 2.8 1 1 1 2 2 2 0 C1 domain DZR PF12773.7 ELR24165.1 - 6.5 6.9 18.3 3.4e+02 1.4 18.3 3.0 1 1 0 1 1 1 0 Double zinc ribbon AI-2E_transport PF01594.16 ELR24166.1 - 3.7e-31 108.5 42.0 2.9e-30 105.6 42.0 2.0 1 1 0 1 1 1 1 AI-2E family transporter UPF0767 PF15990.5 ELR24166.1 - 0.075 13.2 0.1 0.18 11.9 0.1 1.6 1 0 0 1 1 1 0 UPF0767 family DAHP_synth_2 PF01474.16 ELR24167.1 - 3.5e-161 536.6 0.0 2e-85 287.0 0.0 2.5 1 1 1 2 2 2 2 Class-II DAHP synthetase family DUF4505 PF14956.6 ELR24167.1 - 2.5e-19 69.7 0.0 5e-19 68.7 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4505) Far-17a_AIG1 PF04750.14 ELR24168.1 - 1.3e-25 89.9 6.5 1.6e-25 89.7 6.5 1.0 1 0 0 1 1 1 1 FAR-17a/AIG1-like protein COX2_TM PF02790.15 ELR24168.1 - 0.13 12.5 0.3 0.53 10.5 0.1 2.2 1 1 1 2 2 2 0 Cytochrome C oxidase subunit II, transmembrane domain Tetraspanin PF00335.20 ELR24168.1 - 0.66 9.6 3.9 0.4 10.3 0.3 2.1 1 1 2 3 3 3 0 Tetraspanin family Phos_pyr_kin PF08543.12 ELR24169.1 - 5e-17 62.1 0.0 7.3e-17 61.6 0.0 1.2 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase PfkB PF00294.24 ELR24169.1 - 6e-10 38.9 1.7 6.6e-09 35.5 0.0 2.1 2 0 0 2 2 2 2 pfkB family carbohydrate kinase ISN1 PF06437.11 ELR24170.1 - 0.017 14.0 0.1 0.021 13.7 0.1 1.1 1 0 0 1 1 1 0 IMP-specific 5'-nucleotidase DUF5087 PF17006.5 ELR24171.1 - 0.082 12.4 0.1 0.11 12.0 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF5087) RRM_1 PF00076.22 ELR24172.1 - 1.1e-33 114.8 0.0 3e-18 65.4 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 ELR24172.1 - 0.0014 18.2 0.0 0.0045 16.6 0.0 1.8 2 1 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 ELR24172.1 - 0.0089 15.9 0.0 0.022 14.6 0.0 1.7 2 0 0 2 2 2 1 Occluded RNA-recognition motif RRM_8 PF11835.8 ELR24172.1 - 0.18 12.0 0.1 0.61 10.3 0.0 1.9 3 0 0 3 3 3 0 RRM-like domain PG_binding_3 PF09374.10 ELR24173.1 - 0.077 13.3 0.0 0.11 12.8 0.0 1.2 1 0 0 1 1 1 0 Predicted Peptidoglycan domain CaM_binding PF07839.11 ELR24174.1 - 0.08 13.7 1.1 0.11 13.3 1.1 1.2 1 0 0 1 1 1 0 Plant calmodulin-binding domain DUF5539 PF17693.1 ELR24174.1 - 3.1 7.4 13.9 3.8 7.1 13.9 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5539) Ras PF00071.22 ELR24175.1 - 9e-54 181.4 0.1 1e-53 181.3 0.1 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR24175.1 - 3.4e-35 120.9 0.0 4.1e-35 120.6 0.0 1.1 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR24175.1 - 2.4e-14 53.2 0.2 3e-14 52.9 0.2 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 ELR24175.1 - 6.7e-06 25.6 0.1 8.5e-06 25.3 0.1 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 ELR24175.1 - 1.6e-05 24.5 0.1 4.7e-05 23.0 0.1 1.6 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 ELR24175.1 - 0.00011 22.3 0.1 0.00013 22.0 0.1 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.10 ELR24175.1 - 0.0028 17.1 0.0 0.0035 16.8 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit DUF3963 PF13124.6 ELR24175.1 - 0.0062 16.5 0.2 0.013 15.5 0.2 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF3963) MCM PF00493.23 ELR24175.1 - 0.022 13.8 0.0 0.19 10.8 0.0 2.0 2 0 0 2 2 2 0 MCM P-loop domain AAA_29 PF13555.6 ELR24175.1 - 0.033 13.9 0.0 0.096 12.4 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 ELR24175.1 - 0.036 14.0 0.5 0.18 11.7 0.1 2.0 1 1 0 2 2 2 0 RsgA GTPase AAA_16 PF13191.6 ELR24175.1 - 0.066 13.6 0.0 0.077 13.4 0.0 1.2 1 0 0 1 1 1 0 AAA ATPase domain AAA_7 PF12775.7 ELR24175.1 - 0.11 12.1 0.0 0.19 11.2 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_5 PF07728.14 ELR24175.1 - 0.15 12.1 0.0 0.21 11.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) TIP41 PF04176.13 ELR24176.1 - 7.2e-61 204.6 0.2 8.7e-61 204.4 0.2 1.1 1 0 0 1 1 1 1 TIP41-like family Chi-conotoxin PF16981.5 ELR24176.1 - 0.3 11.3 0.5 0.64 10.3 0.5 1.5 1 0 0 1 1 1 0 chi-Conotoxin or t superfamily Iso_dh PF00180.20 ELR24177.1 - 6.7e-68 229.4 0.1 9.3e-68 228.9 0.1 1.1 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase DUF2587 PF10759.9 ELR24177.1 - 0.19 11.3 0.0 0.28 10.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2587) DUF423 PF04241.15 ELR24178.1 - 4.8e-31 106.8 2.2 6.7e-31 106.3 2.2 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF423) DUF2627 PF11118.8 ELR24178.1 - 6.6 7.4 6.4 2.5e+02 2.3 6.4 2.7 1 1 0 1 1 1 0 Protein of unknown function (DUF2627) Innate_immun PF12782.7 ELR24179.1 - 4.6 6.7 8.6 4.5 6.7 0.4 2.1 2 0 0 2 2 2 0 Invertebrate innate immunity transcript family NUP50 PF08911.11 ELR24180.1 - 0.3 11.8 2.1 0.34 11.6 0.2 1.9 2 0 0 2 2 2 0 NUP50 (Nucleoporin 50 kDa) DUF4231 PF14015.6 ELR24180.1 - 0.88 10.1 3.8 1.6 9.2 3.8 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4231) DUF2207 PF09972.9 ELR24180.1 - 4.2 6.0 4.4 5.9 5.5 4.4 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF1325 PF07039.11 ELR24181.1 - 1.3e-32 112.6 0.1 1.3e-32 112.6 0.1 3.0 2 1 1 3 3 3 1 SGF29 tudor-like domain Tudor_3 PF18115.1 ELR24181.1 - 3.9e-05 23.4 0.1 0.0002 21.1 0.0 2.0 2 0 0 2 2 2 1 DNA repair protein Crb2 Tudor domain Pkinase PF00069.25 ELR24182.1 - 2.5e-74 249.9 0.0 2.9e-74 249.8 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR24182.1 - 2e-33 115.8 0.0 2.6e-33 115.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 ELR24182.1 - 5.5e-06 25.6 0.0 5.1e-05 22.4 0.0 1.9 1 1 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 ELR24182.1 - 0.0033 17.4 0.0 0.085 12.8 0.1 2.1 1 1 0 2 2 2 1 Phosphotransferase enzyme family Kinase-like PF14531.6 ELR24182.1 - 0.019 14.3 0.0 0.028 13.8 0.0 1.4 1 0 0 1 1 1 0 Kinase-like Kdo PF06293.14 ELR24182.1 - 0.079 12.3 0.0 0.17 11.2 0.0 1.5 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Ank_2 PF12796.7 ELR24183.1 - 1.1e-31 109.2 4.0 9.1e-15 55.0 0.0 3.3 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ELR24183.1 - 2e-27 95.2 5.1 2.9e-10 40.5 0.1 4.2 1 1 3 4 4 4 4 Ankyrin repeats (many copies) Ank PF00023.30 ELR24183.1 - 2.5e-23 81.4 4.6 1.3e-06 28.6 0.1 4.7 4 0 0 4 4 4 4 Ankyrin repeat Ank_3 PF13606.6 ELR24183.1 - 2.7e-22 76.4 3.6 2.8e-05 24.2 0.0 5.7 6 0 0 6 6 6 3 Ankyrin repeat Ank_5 PF13857.6 ELR24183.1 - 3.9e-21 74.8 3.1 1.9e-10 40.8 0.0 5.0 1 1 4 5 5 5 5 Ankyrin repeats (many copies) F-box-like PF12937.7 ELR24183.1 - 1.9e-10 40.4 0.7 5e-10 39.1 0.2 1.9 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 ELR24183.1 - 8.2e-06 25.6 0.9 2.3e-05 24.1 0.9 1.8 1 1 0 1 1 1 1 F-box domain SPX PF03105.19 ELR24183.1 - 1.1 9.2 8.1 2 8.3 8.1 1.4 1 0 0 1 1 1 0 SPX domain Transferase PF02458.15 ELR24184.1 - 1.3e-27 96.5 0.0 1.5e-10 40.3 0.0 3.1 3 0 0 3 3 3 3 Transferase family Ras PF00071.22 ELR24185.1 - 4.1e-30 104.5 0.1 1.2e-28 99.8 0.1 2.0 1 1 0 1 1 1 1 Ras family Roc PF08477.13 ELR24185.1 - 5.8e-11 42.7 0.0 8.9e-11 42.1 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 ELR24185.1 - 0.00022 21.3 0.0 0.00028 21.0 0.0 1.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 ELR24185.1 - 0.0012 18.4 0.3 0.029 13.9 0.0 2.6 1 1 1 3 3 3 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 ELR24185.1 - 0.0078 16.1 0.5 0.02 14.8 0.5 1.8 1 1 0 1 1 1 1 RsgA GTPase SRPRB PF09439.10 ELR24185.1 - 0.027 13.9 0.0 0.041 13.3 0.0 1.3 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit RNA_helicase PF00910.22 ELR24185.1 - 0.081 13.3 0.0 0.14 12.6 0.0 1.5 1 0 0 1 1 1 0 RNA helicase ABC_tran PF00005.27 ELR24185.1 - 0.092 13.3 0.0 0.092 13.3 0.0 1.4 1 1 0 1 1 1 0 ABC transporter PduV-EutP PF10662.9 ELR24185.1 - 0.097 12.4 0.0 0.39 10.5 0.0 2.0 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation AAA_16 PF13191.6 ELR24185.1 - 0.11 12.9 0.0 0.14 12.5 0.0 1.4 1 1 0 1 1 1 0 AAA ATPase domain Peptidase_C92 PF05708.12 ELR24186.1 - 5.3e-12 46.2 0.0 3e-11 43.7 0.0 2.0 1 1 0 1 1 1 1 Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family C2 PF00168.30 ELR24186.1 - 9.7e-07 29.0 0.8 2.3e-06 27.8 0.0 2.1 2 0 0 2 2 2 1 C2 domain DUF4604 PF15377.6 ELR24186.1 - 0.037 14.4 33.1 0.58 10.6 2.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4604) Carn_acyltransf PF00755.20 ELR24187.1 - 2.5e-175 584.5 0.0 3.4e-175 584.0 0.0 1.2 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase BCS1_N PF08740.11 ELR24187.1 - 4.7e-33 114.7 2.0 8.8e-33 113.9 2.0 1.4 1 0 0 1 1 1 1 BCS1 N terminal AAA PF00004.29 ELR24187.1 - 3.2e-13 50.3 0.0 1.2e-12 48.4 0.0 2.1 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 ELR24187.1 - 0.007 16.8 0.0 0.024 15.0 0.0 2.2 1 0 0 1 1 1 1 AAA ATPase domain DUF815 PF05673.13 ELR24187.1 - 0.012 14.8 0.0 0.03 13.5 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF815) Viral_helicase1 PF01443.18 ELR24187.1 - 0.04 13.6 0.0 0.12 12.1 0.0 1.8 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase RNA_helicase PF00910.22 ELR24187.1 - 0.094 13.1 0.0 0.48 10.8 0.0 2.2 3 0 0 3 3 3 0 RNA helicase ABC_tran PF00005.27 ELR24187.1 - 0.12 12.9 0.0 0.31 11.6 0.0 1.6 1 0 0 1 1 1 0 ABC transporter ATPase PF06745.13 ELR24187.1 - 0.14 11.5 0.0 0.29 10.5 0.0 1.4 1 0 0 1 1 1 0 KaiC Helicase_C PF00271.31 ELR24188.1 - 2.6e-19 69.6 0.0 6.2e-19 68.4 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 ELR24188.1 - 4.4e-16 59.4 2.0 7.2e-16 58.7 0.0 2.1 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DEAD PF00270.29 ELR24188.1 - 5.1e-14 52.4 0.0 9.5e-14 51.5 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase FANCM-MHF_bd PF16783.5 ELR24188.1 - 1.9e-06 27.9 0.0 5.6e-06 26.4 0.0 1.8 1 0 0 1 1 1 1 FANCM to MHF binding domain DUF883 PF05957.13 ELR24189.1 - 6.3e-19 68.4 95.4 0.0013 19.3 3.5 10.1 1 1 9 10 10 10 10 Bacterial protein of unknown function (DUF883) Apolipoprotein PF01442.18 ELR24189.1 - 8e-17 61.7 75.4 6.5e-08 32.7 31.2 5.0 1 1 2 4 4 4 4 Apolipoprotein A1/A4/E domain YtxH PF12732.7 ELR24189.1 - 1.6e-16 60.5 140.3 0.019 15.5 11.4 11.1 3 1 5 8 8 8 5 YtxH-like protein Tmemb_14 PF03647.13 ELR24189.1 - 2.8e-16 60.0 9.4 4.1e-16 59.5 9.4 1.2 1 0 0 1 1 1 1 Transmembrane proteins 14C ApoO PF09769.9 ELR24189.1 - 0.0011 18.9 15.2 20 5.1 0.0 6.9 3 2 2 6 6 6 1 Apolipoprotein O Aim19 PF10315.9 ELR24189.1 - 0.51 10.7 4.1 0.84 9.9 4.1 1.3 1 0 0 1 1 1 0 Altered inheritance of mitochondria protein 19 Mitofilin PF09731.9 ELR24189.1 - 0.63 8.8 89.0 1.8 7.3 58.9 2.6 1 1 1 2 2 2 0 Mitochondrial inner membrane protein ApoLp-III PF07464.11 ELR24189.1 - 5.9 7.0 54.6 2.7 8.1 2.7 5.7 1 1 3 6 6 6 0 Apolipophorin-III precursor (apoLp-III) ubiquitin PF00240.23 ELR24191.1 - 1.5e-07 31.0 0.0 2.2e-07 30.5 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin family DUF2407 PF10302.9 ELR24191.1 - 0.0003 21.3 0.0 0.00049 20.6 0.0 1.3 1 0 0 1 1 1 1 DUF2407 ubiquitin-like domain Rad60-SLD_2 PF13881.6 ELR24191.1 - 0.061 13.4 0.0 0.092 12.9 0.0 1.3 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like Tyr_Deacylase PF02580.16 ELR24193.1 - 6.4e-29 101.3 0.0 7.3e-29 101.2 0.0 1.0 1 0 0 1 1 1 1 D-Tyr-tRNA(Tyr) deacylase Yip1 PF04893.17 ELR24194.1 - 2.1e-09 37.4 21.5 3.5e-09 36.6 20.8 1.8 1 1 0 1 1 1 1 Yip1 domain Ribosomal_L27A PF00828.19 ELR24195.1 - 2.5e-22 79.9 0.3 3.4e-22 79.5 0.3 1.2 1 0 0 1 1 1 1 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A Fungus-induced PF10917.8 ELR24195.1 - 0.47 10.8 0.1 0.47 10.8 0.1 2.3 1 1 1 2 2 2 0 Fungus-induced protein CENP-T_C PF15511.6 ELR24196.1 - 8.2e-09 35.6 0.1 1e-08 35.2 0.1 1.2 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold CENP-S PF15630.6 ELR24196.1 - 0.0001 22.6 0.1 0.00014 22.2 0.1 1.3 1 1 0 1 1 1 1 CENP-S protein TAF PF02969.17 ELR24196.1 - 0.00015 21.8 0.2 0.00021 21.4 0.2 1.3 1 1 0 1 1 1 1 TATA box binding protein associated factor (TAF) Histone PF00125.24 ELR24196.1 - 0.00026 21.4 0.1 0.00029 21.2 0.1 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 ELR24196.1 - 0.00062 20.0 0.1 0.00095 19.4 0.1 1.4 1 1 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID-31kDa PF02291.15 ELR24196.1 - 0.0079 16.3 0.0 0.0094 16.0 0.0 1.1 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit Bromo_TP PF07524.13 ELR24196.1 - 0.01 15.8 0.0 0.014 15.4 0.0 1.2 1 0 0 1 1 1 0 Bromodomain associated HIGH_NTase1_ass PF16581.5 ELR24196.1 - 0.09 12.8 0.1 0.1 12.6 0.1 1.1 1 0 0 1 1 1 0 Cytidyltransferase-related C-terminal region UPF0137 PF03677.13 ELR24196.1 - 0.11 12.3 0.1 0.14 12.0 0.1 1.0 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0137) TAFII28 PF04719.14 ELR24196.1 - 0.14 12.3 0.0 0.17 12.0 0.0 1.2 1 0 0 1 1 1 0 hTAFII28-like protein conserved region PHD PF00628.29 ELR24197.1 - 4.7e-10 39.2 10.5 1.2e-09 38.0 10.5 1.7 1 0 0 1 1 1 1 PHD-finger HTH_23 PF13384.6 ELR24197.1 - 0.0041 16.9 0.0 0.0084 15.9 0.0 1.4 1 0 0 1 1 1 1 Homeodomain-like domain Sigma70_r4_2 PF08281.12 ELR24197.1 - 0.0042 16.7 0.0 0.01 15.5 0.0 1.7 1 0 0 1 1 1 1 Sigma-70, region 4 Sigma70_r4 PF04545.16 ELR24197.1 - 0.048 13.2 0.0 0.21 11.2 0.0 2.0 2 0 0 2 2 2 0 Sigma-70, region 4 GntR PF00392.21 ELR24197.1 - 0.15 11.7 0.0 0.34 10.6 0.0 1.5 1 0 0 1 1 1 0 Bacterial regulatory proteins, gntR family HTH_11 PF08279.12 ELR24197.1 - 0.17 11.8 0.0 0.37 10.8 0.0 1.5 1 0 0 1 1 1 0 HTH domain HTH_Crp_2 PF13545.6 ELR24197.1 - 0.18 11.8 0.0 0.41 10.6 0.0 1.5 1 0 0 1 1 1 0 Crp-like helix-turn-helix domain LIM PF00412.22 ELR24198.1 - 2.2e-14 53.4 5.1 2.2e-14 53.4 5.1 2.4 2 1 0 2 2 2 1 LIM domain DZR PF12773.7 ELR24198.1 - 0.0067 16.4 18.4 11 6.1 18.7 3.6 1 1 0 1 1 1 1 Double zinc ribbon zinc-ribbons_6 PF07191.12 ELR24198.1 - 0.019 14.9 9.9 0.36 10.8 0.1 2.8 2 1 0 2 2 2 0 zinc-ribbons zf-ribbon_3 PF13248.6 ELR24198.1 - 0.023 14.1 3.4 0.023 14.1 3.4 3.1 3 0 0 3 3 3 0 zinc-ribbon domain zinc_ribbon_2 PF13240.6 ELR24198.1 - 0.18 11.6 17.8 0.95 9.3 0.2 4.4 4 0 0 4 4 4 0 zinc-ribbon domain zf-RRN7 PF11781.8 ELR24198.1 - 0.54 10.0 17.0 3 7.6 0.9 4.1 3 2 0 3 3 3 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 Nudix_N_2 PF14803.6 ELR24198.1 - 1.2 9.1 23.8 0.26 11.3 0.8 4.5 5 0 0 5 5 5 0 Nudix N-terminal zf_UBZ PF18439.1 ELR24198.1 - 3.5 7.3 16.0 28 4.4 0.1 4.5 5 0 0 5 5 5 0 Ubiquitin-Binding Zinc Finger ELFV_dehydrog PF00208.21 ELR24199.1 - 2.5e-59 201.0 0.4 9e-58 195.9 0.1 2.1 1 1 1 2 2 2 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase ELFV_dehydrog_N PF02812.18 ELR24199.1 - 4.7e-52 175.3 0.0 6e-51 171.7 0.0 2.2 2 0 0 2 2 2 1 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain 2-Hacid_dh_C PF02826.19 ELR24199.1 - 0.002 17.5 0.2 0.0037 16.6 0.2 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain AdoHcyase_NAD PF00670.21 ELR24199.1 - 0.0058 16.7 0.0 0.013 15.6 0.0 1.5 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain NAD_binding_7 PF13241.6 ELR24199.1 - 0.012 16.0 0.1 0.026 14.9 0.1 1.7 1 1 0 1 1 1 0 Putative NAD(P)-binding ApbA PF02558.16 ELR24199.1 - 0.028 14.1 0.0 0.05 13.3 0.0 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA IlvN PF07991.12 ELR24199.1 - 0.077 12.6 0.3 0.17 11.4 0.3 1.6 1 0 0 1 1 1 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain Bac_GDH PF05088.12 ELR24199.1 - 0.24 8.8 0.0 1.6 6.1 0.0 1.9 2 0 0 2 2 2 0 Bacterial NAD-glutamate dehydrogenase Tubulin PF00091.25 ELR24200.1 - 4.2e-69 232.7 0.0 7e-69 232.0 0.0 1.4 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 ELR24200.1 - 2e-42 144.3 0.3 3.1e-42 143.7 0.3 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_2 PF13809.6 ELR24200.1 - 0.0002 20.6 0.0 0.0046 16.2 0.0 2.1 2 0 0 2 2 2 1 Tubulin like Misat_Tub_SegII PF10644.9 ELR24200.1 - 0.00026 21.3 0.0 0.001 19.4 0.0 2.0 2 0 0 2 2 2 1 Misato Segment II tubulin-like domain Tubulin_3 PF14881.6 ELR24200.1 - 0.005 16.5 0.0 0.0097 15.6 0.0 1.4 1 0 0 1 1 1 1 Tubulin domain Pkinase_Tyr PF07714.17 ELR24201.1 - 4.3e-124 412.9 0.0 1.9e-62 210.9 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 ELR24201.1 - 1.4e-101 339.3 0.0 3.6e-51 174.1 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain PBP_like_2 PF12849.7 ELR24201.1 - 1.8e-28 100.0 12.7 3.5e-15 56.4 1.7 2.6 3 0 0 3 3 3 2 PBP superfamily domain Guanylate_cyc PF00211.20 ELR24201.1 - 7.4e-10 38.7 0.0 1.4e-09 37.8 0.0 1.4 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain APH PF01636.23 ELR24201.1 - 7.1e-07 29.4 0.8 0.00019 21.4 0.1 2.8 2 0 0 2 2 2 2 Phosphotransferase enzyme family Kinase-like PF14531.6 ELR24201.1 - 0.00026 20.4 0.0 0.12 11.6 0.0 2.4 2 0 0 2 2 2 2 Kinase-like Haspin_kinase PF12330.8 ELR24201.1 - 0.0011 17.9 0.0 0.097 11.6 0.0 2.2 2 0 0 2 2 2 1 Haspin like kinase domain Kdo PF06293.14 ELR24201.1 - 0.003 16.9 0.7 0.94 8.8 0.1 2.3 2 0 0 2 2 2 2 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 ELR24201.1 - 0.097 12.3 1.5 8.6 5.9 0.2 2.6 2 1 0 2 2 2 0 RIO1 family PPR_2 PF13041.6 ELR24204.1 - 5.4e-39 132.2 9.9 1.8e-08 34.5 0.0 10.1 6 3 4 10 10 10 7 PPR repeat family PPR_3 PF13812.6 ELR24204.1 - 1.1e-35 121.5 0.4 1.2e-08 34.9 0.0 7.7 6 2 2 9 9 9 7 Pentatricopeptide repeat domain PPR PF01535.20 ELR24204.1 - 2.5e-18 65.0 18.6 0.0038 17.4 0.1 10.5 11 0 0 11 11 11 4 PPR repeat PPR_long PF17177.4 ELR24204.1 - 2e-16 60.0 3.4 2.4e-07 30.4 0.0 5.1 5 1 0 5 5 5 3 Pentacotripeptide-repeat region of PRORP PPR_1 PF12854.7 ELR24204.1 - 1.1e-07 31.4 0.7 0.72 9.6 0.0 6.6 7 0 0 7 7 7 1 PPR repeat Exog_C PF18026.1 ELR24204.1 - 9e-05 22.4 13.2 3.3 7.8 0.1 7.3 9 0 0 9 9 9 3 Endo/exonuclease (EXOG) C-terminal domain ECSIT PF06239.11 ELR24204.1 - 0.0068 15.6 4.8 3.1 6.9 0.0 5.4 3 3 1 4 4 4 2 Evolutionarily conserved signalling intermediate in Toll pathway Ribosomal_60s PF00428.19 ELR24204.1 - 0.021 15.4 0.7 0.021 15.4 0.7 5.4 5 0 0 5 5 5 0 60s Acidic ribosomal protein IMPDH PF00478.25 ELR24205.1 - 4.3e-117 391.0 1.7 5e-117 390.8 1.7 1.0 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain CBS PF00571.28 ELR24205.1 - 1.5e-11 44.6 0.0 0.00015 22.1 0.0 2.9 2 0 0 2 2 2 2 CBS domain NMO PF03060.15 ELR24205.1 - 4.7e-09 36.1 0.3 7e-06 25.6 0.2 2.4 2 0 0 2 2 2 2 Nitronate monooxygenase FMN_dh PF01070.18 ELR24205.1 - 8.7e-08 31.6 2.3 2.9e-07 29.9 0.3 2.4 3 0 0 3 3 3 1 FMN-dependent dehydrogenase Glu_synthase PF01645.17 ELR24205.1 - 2.4e-05 23.7 0.1 2.4e-05 23.7 0.1 2.2 3 0 0 3 3 3 1 Conserved region in glutamate synthase DHO_dh PF01180.21 ELR24205.1 - 8.9e-05 21.8 0.4 0.00022 20.6 0.1 1.7 2 0 0 2 2 2 1 Dihydroorotate dehydrogenase His_biosynth PF00977.21 ELR24205.1 - 0.0052 16.3 1.2 0.013 15.0 0.1 2.1 3 0 0 3 3 3 1 Histidine biosynthesis protein ThiG PF05690.14 ELR24205.1 - 0.0068 15.7 0.1 0.02 14.2 0.0 1.7 2 0 0 2 2 2 1 Thiazole biosynthesis protein ThiG DUF2073 PF09846.9 ELR24205.1 - 0.029 14.2 0.0 0.98 9.3 0.0 2.4 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2073) Dus PF01207.17 ELR24205.1 - 0.038 13.1 0.0 0.077 12.1 0.0 1.5 1 0 0 1 1 1 0 Dihydrouridine synthase (Dus) Usp PF00582.26 ELR24206.1 - 6e-10 39.8 2.2 2.4e-09 37.8 0.0 2.5 1 1 1 2 2 2 1 Universal stress protein family UPF0047 PF01894.17 ELR24207.1 - 2.5e-35 121.1 0.0 3.2e-35 120.7 0.0 1.1 1 0 0 1 1 1 1 Uncharacterised protein family UPF0047 PAS_9 PF13426.7 ELR24208.1 - 0.0053 17.0 0.0 0.01 16.1 0.0 1.4 1 0 0 1 1 1 1 PAS domain PAS_3 PF08447.12 ELR24208.1 - 0.01 16.1 0.0 0.036 14.4 0.0 1.9 1 1 0 1 1 1 0 PAS fold PAS PF00989.25 ELR24208.1 - 0.022 14.8 0.0 0.04 13.9 0.0 1.5 1 0 0 1 1 1 0 PAS fold STAT_alpha PF01017.20 ELR24208.1 - 0.11 12.4 3.8 0.15 11.9 3.8 1.1 1 0 0 1 1 1 0 STAT protein, all-alpha domain BNR PF02012.20 ELR24209.1 - 1.3e-08 33.6 34.3 2.5 8.4 0.0 11.4 9 2 2 11 11 11 7 BNR/Asp-box repeat Sortilin-Vps10 PF15902.5 ELR24209.1 - 3e-07 29.6 8.1 0.5 9.1 0.0 6.8 5 3 3 8 8 8 5 Sortilin, neurotensin receptor 3, Phage_T7_tail PF03906.14 ELR24209.1 - 0.00016 21.3 3.3 0.069 12.8 0.1 3.2 3 0 0 3 3 3 2 Phage T7 tail fibre protein BBS2_Mid PF14783.6 ELR24209.1 - 0.0062 16.6 2.7 3.1 7.9 0.0 3.0 3 0 0 3 3 3 2 Ciliary BBSome complex subunit 2, middle region GSDH PF07995.11 ELR24210.1 - 3.9e-07 29.7 0.1 1.3e-06 27.9 0.1 1.8 1 1 1 2 2 2 1 Glucose / Sorbosone dehydrogenase 2-oxoacid_dh PF00198.23 ELR24211.1 - 1.2e-19 70.7 0.0 9.5e-10 38.3 0.0 2.1 2 0 0 2 2 2 2 2-oxoacid dehydrogenases acyltransferase (catalytic domain) LRR_8 PF13855.6 ELR24214.1 - 5.4e-16 58.1 3.6 1.5e-07 31.1 0.0 3.7 2 1 1 3 3 3 3 Leucine rich repeat LRR_4 PF12799.7 ELR24214.1 - 6e-09 36.0 8.3 0.011 16.1 0.9 3.8 3 0 0 3 3 3 3 Leucine Rich repeats (2 copies) DUF3446 PF11928.8 ELR24214.1 - 0.0025 18.1 3.6 0.028 14.7 4.2 2.1 2 0 0 2 2 2 1 Early growth response N-terminal domain LRR_9 PF14580.6 ELR24214.1 - 0.018 14.5 0.7 1.6 8.2 0.1 2.6 2 1 1 3 3 3 0 Leucine-rich repeat IQCJ-SCHIP1 PF15157.6 ELR24214.1 - 0.049 13.5 0.9 0.08 12.8 0.9 1.3 1 0 0 1 1 1 0 Fusion protein IQCJ-SCHIP1 with IQ-like motif SR-25 PF10500.9 ELR24214.1 - 0.19 11.3 8.2 0.28 10.7 8.2 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein VATC PF18716.1 ELR24214.1 - 7.1 6.6 7.3 1.2 9.0 0.5 2.9 3 0 0 3 3 3 0 Vms1-associating treble clef domain SH3_1 PF00018.28 ELR24215.1 - 2.5e-23 81.4 11.6 1.5e-09 37.3 0.1 5.2 5 0 0 5 5 5 3 SH3 domain SH3_9 PF14604.6 ELR24215.1 - 1.1e-21 76.4 5.3 7.7e-13 48.1 0.2 4.6 4 0 0 4 4 4 2 Variant SH3 domain SH3_2 PF07653.17 ELR24215.1 - 3.9e-21 74.5 7.7 8.4e-11 41.4 0.1 4.9 4 1 0 4 4 4 3 Variant SH3 domain F-box-like PF12937.7 ELR24215.1 - 9.5e-08 31.8 1.4 1.6e-07 31.1 1.4 1.4 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ELR24215.1 - 4.1e-05 23.3 0.6 6.9e-05 22.6 0.6 1.3 1 0 0 1 1 1 1 F-box domain SH3_3 PF08239.11 ELR24215.1 - 0.05 13.9 5.9 1.8 8.9 0.2 4.0 4 0 0 4 4 4 0 Bacterial SH3 domain DUF4407 PF14362.6 ELR24215.1 - 2.5 7.4 15.6 6.1 6.1 12.8 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) DUF563 PF04577.14 ELR24216.1 - 4e-12 46.7 0.0 8.3e-12 45.7 0.0 1.5 1 1 0 1 1 1 1 Protein of unknown function (DUF563) CHASE2 PF05226.11 ELR24216.1 - 0.017 14.9 0.0 0.025 14.3 0.0 1.4 1 0 0 1 1 1 0 CHASE2 domain CIMR PF00878.18 ELR24217.1 - 0.0036 17.4 0.0 0.0046 17.0 0.0 1.1 1 0 0 1 1 1 1 Cation-independent mannose-6-phosphate receptor repeat SMI1_KNR4 PF09346.10 ELR24218.1 - 0.00011 22.6 0.2 0.00065 20.1 0.2 1.9 1 1 0 1 1 1 1 SMI1 / KNR4 family (SUKH-1) SAP PF02037.27 ELR24219.1 - 7.1e-05 22.5 0.0 0.00012 21.7 0.0 1.4 1 0 0 1 1 1 1 SAP domain SMI1_KNR4 PF09346.10 ELR24219.1 - 0.0048 17.3 0.1 0.0048 17.3 0.1 3.1 2 2 0 2 2 1 1 SMI1 / KNR4 family (SUKH-1) BUD22 PF09073.10 ELR24219.1 - 0.024 14.0 27.1 0.031 13.6 27.1 1.1 1 0 0 1 1 1 0 BUD22 SDA1 PF05285.12 ELR24219.1 - 0.074 12.5 26.2 0.14 11.5 26.2 1.4 1 0 0 1 1 1 0 SDA1 Presenilin PF01080.17 ELR24219.1 - 0.36 9.6 11.2 0.45 9.2 11.2 1.1 1 0 0 1 1 1 0 Presenilin Vfa1 PF08432.10 ELR24219.1 - 0.91 9.8 18.8 1.6 9.0 18.8 1.4 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 DUF3295 PF11702.8 ELR24219.1 - 0.95 8.7 23.1 1.3 8.3 23.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3295) Apt1 PF10351.9 ELR24219.1 - 1.2 7.9 7.5 1.5 7.6 7.5 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain Zip PF02535.22 ELR24219.1 - 1.3 8.1 7.1 1.8 7.7 7.1 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter FAM60A PF15396.6 ELR24219.1 - 1.4 8.9 7.1 2.5 8.0 7.1 1.4 1 0 0 1 1 1 0 Protein Family FAM60A NPR3 PF03666.13 ELR24219.1 - 8 5.1 15.3 11 4.7 15.3 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Drc1-Sld2 PF11719.8 ELR24219.1 - 8 5.9 23.6 11 5.4 23.6 1.1 1 0 0 1 1 1 0 DNA replication and checkpoint protein Ras PF00071.22 ELR24220.1 - 6.5e-29 100.6 0.1 9.2e-28 96.9 0.1 2.3 1 1 0 1 1 1 1 Ras family BTB PF00651.31 ELR24220.1 - 4.8e-16 59.0 0.1 8.4e-10 38.9 0.0 3.0 3 0 0 3 3 3 2 BTB/POZ domain Roc PF08477.13 ELR24220.1 - 4.5e-11 43.0 0.0 9.8e-11 41.9 0.0 1.6 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase AAA_16 PF13191.6 ELR24220.1 - 0.093 13.1 0.2 16 5.9 0.0 3.6 2 1 1 3 3 3 0 AAA ATPase domain F-box-like PF12937.7 ELR24223.1 - 0.14 12.1 10.7 0.28 11.1 7.9 2.8 2 1 0 2 2 2 0 F-box-like Hemerythrin PF01814.23 ELR24224.1 - 2.3e-13 50.9 2.7 3.2e-13 50.4 2.7 1.2 1 0 0 1 1 1 1 Hemerythrin HHE cation binding domain DUF1359 PF07097.11 ELR24224.1 - 0.019 15.2 0.1 0.043 14.0 0.0 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1359) 4HB_MCP_1 PF12729.7 ELR24224.1 - 0.038 13.5 0.4 0.056 13.0 0.4 1.3 1 0 0 1 1 1 0 Four helix bundle sensory module for signal transduction Herpes_UL21 PF03252.13 ELR24224.1 - 0.049 12.4 0.1 0.056 12.2 0.1 1.0 1 0 0 1 1 1 0 Herpesvirus UL21 Peptidase_M20 PF01546.28 ELR24225.1 - 2.8e-35 121.9 0.1 3.8e-35 121.5 0.1 1.2 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 ELR24225.1 - 2.6e-14 53.0 0.0 5.6e-14 52.0 0.0 1.6 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M42 PF05343.14 ELR24225.1 - 0.44 9.5 1.3 30 3.5 0.0 3.0 4 0 0 4 4 4 0 M42 glutamyl aminopeptidase Ank_2 PF12796.7 ELR24226.1 - 1.4e-34 118.5 6.3 2.4e-15 56.9 0.2 3.4 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank PF00023.30 ELR24226.1 - 1e-31 108.0 2.6 7.8e-08 32.4 0.0 6.9 6 0 0 6 6 6 5 Ankyrin repeat Ank_4 PF13637.6 ELR24226.1 - 3.3e-31 107.3 1.8 1.1e-06 29.1 0.0 5.4 2 2 3 5 5 5 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 ELR24226.1 - 1.3e-27 92.8 0.5 4e-05 23.7 0.0 7.2 6 0 0 6 6 6 4 Ankyrin repeat Ank_5 PF13857.6 ELR24226.1 - 2.4e-25 88.3 2.4 3.6e-08 33.5 0.0 5.4 2 2 4 6 6 6 6 Ankyrin repeats (many copies) Atg14 PF10186.9 ELR24226.1 - 1.6e-11 43.8 0.3 2.4e-11 43.3 0.3 1.2 1 0 0 1 1 1 1 Vacuolar sorting 38 and autophagy-related subunit 14 APG6 PF04111.12 ELR24226.1 - 0.00017 21.6 0.0 0.0079 16.2 0.0 2.3 2 0 0 2 2 2 1 Apg6 BARA domain C2 PF00168.30 ELR24226.1 - 0.0051 17.1 0.0 0.011 16.0 0.0 1.4 1 0 0 1 1 1 1 C2 domain DSBA PF01323.20 ELR24227.1 - 0.0015 18.3 0.0 0.032 14.0 0.0 2.0 1 1 1 2 2 2 2 DSBA-like thioredoxin domain Ketoacyl-synt_C PF02801.22 ELR24227.1 - 0.21 11.6 0.0 0.32 11.0 0.0 1.2 1 0 0 1 1 1 0 Beta-ketoacyl synthase, C-terminal domain DUF4984 PF16372.5 ELR24228.1 - 0.04 13.8 0.0 0.04 13.8 0.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4984) DSBA PF01323.20 ELR24230.1 - 0.0019 18.0 0.0 0.036 13.8 0.0 2.0 1 1 1 2 2 2 1 DSBA-like thioredoxin domain Ketoacyl-synt_C PF02801.22 ELR24230.1 - 0.22 11.5 0.0 0.36 10.9 0.0 1.3 1 0 0 1 1 1 0 Beta-ketoacyl synthase, C-terminal domain VWA PF00092.28 ELR24231.1 - 2.1e-16 60.7 0.0 5.9e-16 59.2 0.0 1.8 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.6 ELR24231.1 - 3.7e-15 56.5 0.0 1e-14 55.1 0.0 1.7 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_3 PF13768.6 ELR24231.1 - 1.7e-07 31.3 0.0 4.1e-07 30.1 0.0 1.7 1 0 0 1 1 1 1 von Willebrand factor type A domain vWA-TerF-like PF10138.9 ELR24231.1 - 0.002 18.2 0.0 0.0039 17.3 0.0 1.5 1 0 0 1 1 1 1 vWA found in TerF C terminus Use1 PF09753.9 ELR24231.1 - 0.098 12.4 2.5 0.15 11.7 2.5 1.2 1 0 0 1 1 1 0 Membrane fusion protein Use1 VWA_CoxE PF05762.14 ELR24231.1 - 0.13 11.6 0.1 0.35 10.2 0.1 1.7 1 1 0 1 1 1 0 VWA domain containing CoxE-like protein LRR_4 PF12799.7 ELR24232.1 - 4.9e-11 42.7 1.3 0.00039 20.8 0.9 2.3 2 0 0 2 2 2 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 ELR24232.1 - 6.6e-10 38.6 5.0 0.00039 20.1 0.0 2.3 2 0 0 2 2 2 2 Leucine rich repeat LRR_1 PF00560.33 ELR24232.1 - 0.0033 17.8 1.4 0.09 13.4 0.0 3.3 4 0 0 4 4 4 1 Leucine Rich Repeat LRR_6 PF13516.6 ELR24232.1 - 0.0082 16.1 0.4 0.32 11.1 0.0 3.5 4 0 0 4 4 4 1 Leucine Rich repeat RRM_1 PF00076.22 ELR24233.1 - 1.7e-33 114.2 0.0 2.9e-14 52.6 0.0 3.3 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 ELR24233.1 - 1.7e-07 30.8 0.0 0.018 14.7 0.0 3.2 1 1 2 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 ELR24233.1 - 0.0027 17.5 0.0 0.36 10.7 0.0 2.7 3 0 0 3 3 3 1 Occluded RNA-recognition motif SDA1 PF05285.12 ELR24233.1 - 0.036 13.5 2.7 0.047 13.1 2.7 1.1 1 0 0 1 1 1 0 SDA1 RRM_7 PF16367.5 ELR24233.1 - 0.038 14.1 0.0 8 6.7 0.0 2.7 3 0 0 3 3 3 0 RNA recognition motif CDC45 PF02724.14 ELR24233.1 - 0.55 8.5 4.7 0.77 8.0 4.7 1.1 1 0 0 1 1 1 0 CDC45-like protein Peptidase_M20 PF01546.28 ELR24235.1 - 8.8e-27 94.2 0.0 1.2e-26 93.7 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 ELR24235.1 - 6.8e-15 54.9 0.0 1.3e-14 54.0 0.0 1.5 1 0 0 1 1 1 1 Peptidase dimerisation domain R3H PF01424.22 ELR24236.1 - 2.6e-07 30.5 0.0 7e-07 29.1 0.0 1.8 1 0 0 1 1 1 1 R3H domain Exo_endo_phos PF03372.23 ELR24236.1 - 7.8e-07 28.8 0.1 4.3e-06 26.4 0.0 2.2 2 1 0 2 2 2 1 Endonuclease/Exonuclease/phosphatase family Metal_resist PF13801.6 ELR24236.1 - 0.26 11.5 10.4 1 9.6 1.2 3.3 1 1 2 3 3 3 0 Heavy-metal resistance SAM_1 PF00536.30 ELR24237.1 - 4e-14 52.8 0.0 1e-13 51.5 0.0 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 ELR24237.1 - 8.4e-12 45.0 0.0 2.2e-11 43.7 0.0 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Costars PF14705.6 ELR24237.1 - 4.6e-11 42.7 0.0 1e-10 41.6 0.0 1.6 1 0 0 1 1 1 1 Costars LIM PF00412.22 ELR24237.1 - 1.6e-10 41.1 4.6 2.8e-10 40.3 4.6 1.4 1 0 0 1 1 1 1 LIM domain Chi-conotoxin PF16981.5 ELR24238.1 - 0.14 12.4 0.6 1.7 8.9 0.3 2.7 2 0 0 2 2 2 0 chi-Conotoxin or t superfamily DUF3339 PF11820.8 ELR24239.1 - 4e-11 43.0 0.5 5.2e-11 42.6 0.5 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3339) DUF3681 PF12442.8 ELR24239.1 - 0.0071 16.8 0.0 0.0086 16.5 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3681) AhpC-TSA PF00578.21 ELR24240.1 - 4.8e-24 84.7 0.0 8e-24 83.9 0.0 1.4 1 0 0 1 1 1 1 AhpC/TSA family 1-cysPrx_C PF10417.9 ELR24240.1 - 1.2e-11 44.3 0.1 2.1e-11 43.4 0.1 1.5 1 0 0 1 1 1 1 C-terminal domain of 1-Cys peroxiredoxin Redoxin PF08534.10 ELR24240.1 - 8.1e-07 28.9 0.0 1.3e-06 28.2 0.0 1.3 1 0 0 1 1 1 1 Redoxin RhoGEF PF00621.20 ELR24241.1 - 3.1e-21 76.5 0.1 7.6e-21 75.2 0.1 1.6 1 0 0 1 1 1 1 RhoGEF domain PH_13 PF16652.5 ELR24241.1 - 4.3e-06 26.6 0.8 4e-05 23.5 0.1 2.3 1 1 1 2 2 2 1 Pleckstrin homology domain PH PF00169.29 ELR24241.1 - 5.2e-05 23.7 0.1 0.00012 22.6 0.1 1.6 1 0 0 1 1 1 1 PH domain PH_16 PF17838.1 ELR24241.1 - 0.0059 16.4 0.0 0.016 15.0 0.0 1.8 1 1 0 1 1 1 1 PH domain SH3_1 PF00018.28 ELR24242.1 - 0.00014 21.4 0.0 0.00026 20.5 0.0 1.4 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 ELR24242.1 - 0.00035 20.4 0.0 0.00072 19.4 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 ELR24242.1 - 0.0059 16.3 0.0 0.012 15.2 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain RhoGEF PF00621.20 ELR24242.1 - 0.11 12.7 0.4 0.26 11.5 0.0 1.7 2 0 0 2 2 2 0 RhoGEF domain Alpha_L_fucos PF01120.17 ELR24243.1 - 7.3e-112 374.3 4.4 1.2e-111 373.6 4.4 1.3 1 0 0 1 1 1 1 Alpha-L-fucosidase Fucosidase_C PF16757.5 ELR24243.1 - 1.1e-13 51.5 0.4 2.1e-13 50.6 0.4 1.5 1 0 0 1 1 1 1 Alpha-L-fucosidase C-terminal domain DIOX_N PF14226.6 ELR24245.1 - 8.6e-09 36.2 0.0 2e-08 35.0 0.0 1.6 2 0 0 2 2 2 1 non-haem dioxygenase in morphine synthesis N-terminal Ank_2 PF12796.7 ELR24246.1 - 1.6e-53 179.2 13.2 8e-09 36.0 1.8 10.0 6 2 3 10 10 10 10 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ELR24246.1 - 4.8e-45 151.4 17.3 0.00026 21.5 0.0 14.8 10 3 5 15 15 15 9 Ankyrin repeats (many copies) Ank_3 PF13606.6 ELR24246.1 - 5.1e-40 130.9 12.8 0.00028 21.1 0.0 16.6 17 0 0 17 17 17 7 Ankyrin repeat Ank_5 PF13857.6 ELR24246.1 - 3.3e-37 126.1 22.8 4.2e-05 23.7 0.6 12.8 10 3 4 14 14 14 9 Ankyrin repeats (many copies) Ank PF00023.30 ELR24246.1 - 1.2e-29 101.4 35.9 0.00094 19.5 0.1 15.1 17 0 0 17 17 17 7 Ankyrin repeat acVLRF1 PF18859.1 ELR24246.1 - 0.046 14.0 0.1 0.18 12.1 0.1 2.1 1 0 0 1 1 1 0 Actinobacteria/chloroflexi VLRF1 release factor Hamartin PF04388.12 ELR24246.1 - 0.62 8.7 10.7 1.3 7.6 10.7 1.5 1 0 0 1 1 1 0 Hamartin protein PARP PF00644.20 ELR24247.1 - 2.2e-43 148.1 0.0 1.9e-42 145.1 0.0 2.3 1 1 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain PARP_reg PF02877.14 ELR24247.1 - 2.5e-24 85.9 0.0 7.6e-24 84.3 0.0 1.8 2 0 0 2 2 2 1 Poly(ADP-ribose) polymerase, regulatory domain WGR PF05406.15 ELR24247.1 - 6.5e-10 38.9 1.9 6.5e-10 38.9 1.9 2.2 2 1 0 2 2 2 1 WGR domain Peptidase_C37 PF05416.12 ELR24247.1 - 7.9 4.9 9.0 0.18 10.3 0.6 2.0 2 0 0 2 2 2 0 Southampton virus-type processing peptidase DUF1343 PF07075.11 ELR24248.1 - 6.9e-72 242.7 0.0 5.9e-71 239.7 0.0 2.1 1 1 0 1 1 1 1 Protein of unknown function (DUF1343) NAD_binding_8 PF13450.6 ELR24248.1 - 0.021 15.0 0.0 0.14 12.4 0.0 2.3 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain UCH PF00443.29 ELR24249.1 - 2e-55 188.1 0.7 2e-55 188.1 0.7 1.7 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 ELR24249.1 - 1.8e-09 37.6 2.6 0.00066 19.4 0.9 2.7 1 1 1 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase Peptidase_C98 PF15499.6 ELR24249.1 - 0.73 9.3 4.6 0.93 8.9 0.3 2.2 2 0 0 2 2 2 0 Ubiquitin-specific peptidase-like, SUMO isopeptidase FYVE PF01363.21 ELR24250.1 - 0.00061 19.9 5.0 0.0017 18.5 5.0 1.7 1 0 0 1 1 1 1 FYVE zinc finger TTL PF03133.15 ELR24250.1 - 0.13 11.3 0.8 0.2 10.8 0.3 1.5 2 0 0 2 2 2 0 Tubulin-tyrosine ligase family ATP11 PF06644.11 ELR24250.1 - 0.33 10.7 3.8 17 5.1 0.0 2.2 2 0 0 2 2 2 0 ATP11 protein DUF2868 PF11067.8 ELR24250.1 - 1.1 8.8 4.8 2.3 7.6 4.8 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2868) FYVE_2 PF02318.16 ELR24250.1 - 2.4 8.4 9.4 0.36 11.1 3.9 2.4 2 0 0 2 2 2 0 FYVE-type zinc finger RhoGEF PF00621.20 ELR24251.1 - 7e-13 49.2 0.3 2.2e-12 47.6 0.3 1.8 1 0 0 1 1 1 1 RhoGEF domain PH_13 PF16652.5 ELR24251.1 - 2.2e-06 27.6 1.1 2.1e-05 24.4 0.1 2.2 1 1 1 2 2 2 1 Pleckstrin homology domain PH PF00169.29 ELR24251.1 - 3e-05 24.5 0.2 7e-05 23.3 0.2 1.7 1 1 0 1 1 1 1 PH domain PH_16 PF17838.1 ELR24251.1 - 0.0035 17.2 0.0 0.0086 15.9 0.0 1.7 1 1 0 1 1 1 1 PH domain Dfp1_Him1_M PF08630.10 ELR24251.1 - 0.15 12.3 1.1 0.37 11.0 0.6 1.8 1 1 1 2 2 2 0 Dfp1/Him1, central region TPR_19 PF14559.6 ELR24252.1 - 7.6e-05 23.1 0.1 0.00033 21.1 0.1 1.9 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_2 PF07719.17 ELR24252.1 - 0.00096 19.1 0.0 0.028 14.5 0.0 2.7 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.6 ELR24252.1 - 0.001 19.7 0.8 0.26 12.2 0.4 3.4 1 1 2 3 3 3 2 Tetratricopeptide repeat TPR_15 PF13429.6 ELR24252.1 - 0.0037 16.5 0.2 0.01 15.1 0.1 1.7 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_16 PF13432.6 ELR24252.1 - 0.011 16.4 0.3 0.054 14.1 0.5 2.2 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_12 PF13424.6 ELR24252.1 - 0.052 13.9 1.2 0.1 12.9 1.2 1.5 1 0 0 1 1 1 0 Tetratricopeptide repeat DUF98 PF01947.16 ELR24252.1 - 0.095 12.7 0.0 1 9.3 0.0 2.0 2 0 0 2 2 2 0 p-hydroxybenzoic acid synthase TPR_17 PF13431.6 ELR24252.1 - 0.11 13.0 0.6 0.21 12.0 0.1 1.8 2 0 0 2 2 2 0 Tetratricopeptide repeat SRP-alpha_N PF04086.13 ELR24253.1 - 0.053 13.4 16.8 0.072 13.0 16.8 1.2 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal Apt1 PF10351.9 ELR24253.1 - 1.3 7.8 13.4 1.4 7.7 13.4 1.0 1 0 0 1 1 1 0 Golgi-body localisation protein domain CDC27 PF09507.10 ELR24253.1 - 1.8 7.9 25.2 2.4 7.4 25.2 1.3 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 SpoIIIAH PF12685.7 ELR24253.1 - 4.4 7.1 9.3 6.6 6.5 9.3 1.2 1 0 0 1 1 1 0 SpoIIIAH-like protein eIF3_subunit PF08597.10 ELR24253.1 - 5.1 6.9 27.2 7.2 6.4 27.2 1.2 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit VIR_N PF15912.5 ELR24253.1 - 6.5 6.3 21.6 8.3 5.9 21.2 1.5 1 1 0 1 1 1 0 Virilizer, N-terminal AAA_11 PF13086.6 ELR24253.1 - 7.4 6.3 12.8 11 5.7 12.8 1.2 1 0 0 1 1 1 0 AAA domain Raftlin PF15250.6 ELR24253.1 - 9.4 4.9 10.7 11 4.6 10.7 1.0 1 0 0 1 1 1 0 Raftlin Presenilin PF01080.17 ELR24253.1 - 9.8 4.8 18.2 12 4.5 18.2 1.1 1 0 0 1 1 1 0 Presenilin HA PF03457.14 ELR24254.1 - 1.6e-13 50.8 1.5 2.7e-13 50.0 1.5 1.4 1 0 0 1 1 1 1 Helicase associated domain Utp14 PF04615.13 ELR24254.1 - 0.063 11.8 17.1 0.078 11.5 17.1 1.1 1 0 0 1 1 1 0 Utp14 protein Nop14 PF04147.12 ELR24254.1 - 1.1 7.4 26.3 1.5 6.9 26.3 1.1 1 0 0 1 1 1 0 Nop14-like family Profilin PF00235.19 ELR24257.1 - 1.1e-27 96.8 0.0 1.3e-27 96.6 0.0 1.0 1 0 0 1 1 1 1 Profilin BON PF04972.17 ELR24257.1 - 0.097 13.0 0.1 0.16 12.3 0.1 1.4 1 0 0 1 1 1 0 BON domain DER1 PF04511.15 ELR24258.1 - 1.6e-52 178.3 13.9 1.8e-52 178.1 13.9 1.0 1 0 0 1 1 1 1 Der1-like family STT3 PF02516.14 ELR24259.1 - 8.4e-138 460.3 42.7 7.9e-133 443.9 39.0 2.0 2 0 0 2 2 2 2 Oligosaccharyl transferase STT3 subunit OAD_gamma PF04277.13 ELR24260.1 - 0.083 13.5 0.1 0.29 11.7 0.1 2.0 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain DUF3285 PF11688.8 ELR24260.1 - 0.14 12.1 2.4 0.66 9.9 0.4 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3285) 3Beta_HSD PF01073.19 ELR24261.1 - 9.7e-56 188.8 0.0 1.3e-55 188.4 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 ELR24261.1 - 9e-32 110.4 0.0 1.6e-31 109.6 0.0 1.4 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 ELR24261.1 - 1.6e-18 67.2 0.1 9.3e-15 54.8 0.0 2.4 2 1 0 2 2 2 2 GDP-mannose 4,6 dehydratase NAD_binding_4 PF07993.12 ELR24261.1 - 1.3e-17 63.8 0.1 3e-14 52.8 0.1 2.2 1 1 0 1 1 1 1 Male sterility protein NAD_binding_10 PF13460.6 ELR24261.1 - 4e-14 52.9 0.0 6.8e-14 52.2 0.0 1.4 1 0 0 1 1 1 1 NAD(P)H-binding Polysacc_synt_2 PF02719.15 ELR24261.1 - 4.6e-10 39.1 0.0 1.5e-09 37.5 0.0 1.7 2 0 0 2 2 2 1 Polysaccharide biosynthesis protein RmlD_sub_bind PF04321.17 ELR24261.1 - 2.7e-09 36.5 0.0 4e-09 36.0 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain KR PF08659.10 ELR24261.1 - 0.00026 20.9 0.0 0.0016 18.4 0.0 2.0 1 1 0 1 1 1 1 KR domain NmrA PF05368.13 ELR24261.1 - 0.00027 20.6 0.0 0.00053 19.6 0.0 1.5 1 1 0 1 1 1 1 NmrA-like family TrkA_N PF02254.18 ELR24261.1 - 0.0023 18.2 0.0 0.0053 17.0 0.0 1.5 1 0 0 1 1 1 1 TrkA-N domain DSPc PF00782.20 ELR24262.1 - 9.2e-29 99.9 0.0 1.5e-28 99.2 0.0 1.4 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 ELR24262.1 - 0.00083 19.0 0.0 0.0013 18.3 0.0 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Cas_Csx8 PF09657.10 ELR24262.1 - 0.026 13.5 0.1 0.03 13.3 0.1 1.1 1 0 0 1 1 1 0 CRISPR-associated protein Csx8 (Cas_Csx8) PTPlike_phytase PF14566.6 ELR24262.1 - 0.27 11.4 0.1 0.27 11.4 0.1 2.0 2 0 0 2 2 2 0 Inositol hexakisphosphate RhoGEF PF00621.20 ELR24263.1 - 1.6e-26 93.6 0.0 5.9e-26 91.8 0.0 1.9 2 0 0 2 2 2 1 RhoGEF domain PH PF00169.29 ELR24263.1 - 1e-06 29.2 0.0 2.7e-06 27.8 0.0 1.8 1 0 0 1 1 1 1 PH domain Androgen_recep PF02166.16 ELR24263.1 - 4e-05 22.7 5.7 7.1e-05 21.8 5.7 1.4 1 0 0 1 1 1 1 Androgen receptor IQ_SEC7_PH PF16453.5 ELR24263.1 - 0.00013 22.0 0.0 0.00027 20.9 0.0 1.5 1 0 0 1 1 1 1 PH domain PH_13 PF16652.5 ELR24263.1 - 0.01 15.7 0.6 0.031 14.1 0.0 2.0 2 0 0 2 2 2 0 Pleckstrin homology domain MTBP_C PF14920.6 ELR24263.1 - 0.75 9.5 16.0 0.08 12.7 10.8 1.9 2 0 0 2 2 2 0 MDM2-binding Spt20 PF12090.8 ELR24263.1 - 0.83 9.2 15.2 1.8 8.1 15.2 1.5 1 0 0 1 1 1 0 Spt20 family Macoilin PF09726.9 ELR24263.1 - 1.8 7.0 9.7 2.9 6.4 9.7 1.3 1 0 0 1 1 1 0 Macoilin family DUF5327 PF17261.2 ELR24263.1 - 3.2 8.6 8.2 4.6 8.0 4.6 2.8 3 0 0 3 3 3 0 Family of unknown function (DUF5327) Presenilin PF01080.17 ELR24263.1 - 5.8 5.6 9.4 9.4 4.9 9.4 1.3 1 0 0 1 1 1 0 Presenilin Endonuclease_5 PF04493.14 ELR24264.1 - 1.4e-40 139.1 0.0 2.5e-40 138.3 0.0 1.4 1 0 0 1 1 1 1 Endonuclease V Ank_4 PF13637.6 ELR24264.1 - 3.2e-29 100.9 3.5 3.2e-08 34.0 0.1 5.3 2 2 3 5 5 5 4 Ankyrin repeats (many copies) Ank_2 PF12796.7 ELR24264.1 - 2.5e-28 98.5 8.9 1.1e-15 58.0 0.7 3.5 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_5 PF13857.6 ELR24264.1 - 1.1e-22 79.8 9.7 3.6e-08 33.5 0.1 5.1 2 1 2 4 4 4 4 Ankyrin repeats (many copies) Ank PF00023.30 ELR24264.1 - 1.7e-19 69.3 8.8 0.0011 19.3 0.2 7.3 7 0 0 7 7 7 5 Ankyrin repeat Ank_3 PF13606.6 ELR24264.1 - 9.8e-18 62.4 2.4 0.033 14.7 0.0 6.3 5 1 0 5 5 5 4 Ankyrin repeat SAM_1 PF00536.30 ELR24264.1 - 5.2e-08 33.2 0.0 3.1e-07 30.7 0.0 2.1 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 ELR24264.1 - 6.1e-08 32.7 0.0 1.3e-07 31.6 0.0 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) DAHP_synth_1 PF00793.20 ELR24264.1 - 0.093 11.6 0.2 0.14 11.0 0.2 1.2 1 0 0 1 1 1 0 DAHP synthetase I family RNA_pol_Rpb5_C PF01191.19 ELR24265.1 - 2.1e-34 117.2 0.5 4.7e-34 116.1 0.5 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb5, C-terminal domain RNA_pol_Rpb5_N PF03871.14 ELR24265.1 - 1.7e-27 95.8 0.1 3.8e-27 94.7 0.0 1.6 2 0 0 2 2 2 1 RNA polymerase Rpb5, N-terminal domain UCH PF00443.29 ELR24267.1 - 3.4e-31 108.7 0.0 5.8e-31 107.9 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 ELR24267.1 - 1.8e-07 31.1 5.4 5.7e-06 26.2 0.2 2.5 1 1 1 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase UIM PF02809.20 ELR24267.1 - 0.25 11.4 12.8 1.8 8.6 1.2 3.0 2 0 0 2 2 2 0 Ubiquitin interaction motif UCH PF00443.29 ELR24268.1 - 4.1e-07 29.8 0.4 4.1e-07 29.8 0.4 1.9 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UIM PF02809.20 ELR24268.1 - 7.5e-05 22.4 2.9 7.5e-05 22.4 2.9 2.4 2 0 0 2 2 2 1 Ubiquitin interaction motif FYVE PF01363.21 ELR24269.1 - 5e-22 77.8 9.1 9.3e-22 77.0 9.1 1.5 1 0 0 1 1 1 1 FYVE zinc finger zf-4CXXC_R1 PF10497.9 ELR24269.1 - 0.059 13.6 4.9 0.14 12.4 4.9 1.6 1 0 0 1 1 1 0 Zinc-finger domain of monoamine-oxidase A repressor R1 MAJIN PF15077.6 ELR24269.1 - 0.3 10.9 2.3 0.51 10.1 2.3 1.3 1 0 0 1 1 1 0 Membrane-anchored junction protein Opy2 PF09463.10 ELR24269.1 - 1.3 9.4 7.0 0.43 10.9 2.9 2.2 2 0 0 2 2 2 0 Opy2 protein UCH PF00443.29 ELR24271.1 - 1.8e-44 152.2 0.1 1e-43 149.7 0.1 2.1 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 ELR24271.1 - 1.3e-11 44.7 2.3 2.6e-09 37.1 0.0 2.5 1 1 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase UIM PF02809.20 ELR24271.1 - 1.4e-05 24.6 23.4 0.00028 20.6 2.9 4.2 3 0 0 3 3 3 3 Ubiquitin interaction motif RCC1 PF00415.18 ELR24272.1 - 2.1e-42 143.5 25.7 7.7e-13 48.8 0.8 9.1 6 3 1 7 7 7 6 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 ELR24272.1 - 1.5e-23 82.0 32.2 3.6e-09 36.2 1.8 7.1 7 0 0 7 7 7 6 Regulator of chromosome condensation (RCC1) repeat BTB PF00651.31 ELR24272.1 - 1.4e-21 76.8 1.0 1.3e-13 51.1 0.0 4.1 4 1 1 5 5 5 2 BTB/POZ domain FYVE PF01363.21 ELR24272.1 - 0.0026 17.9 4.9 0.0086 16.2 4.9 1.9 1 0 0 1 1 1 1 FYVE zinc finger HSP20 PF00011.21 ELR24273.1 - 2e-12 47.1 0.0 7e-11 42.2 0.0 2.6 2 0 0 2 2 2 1 Hsp20/alpha crystallin family SR-25 PF10500.9 ELR24275.1 - 0.31 10.6 4.0 0.32 10.6 4.0 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein DUF222 PF02720.17 ELR24277.1 - 0.0027 17.2 1.7 0.0031 17.0 1.7 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF222) PSK_trans_fac PF07704.11 ELR24277.1 - 0.9 10.3 8.0 0.38 11.5 4.0 2.2 1 1 1 2 2 2 0 Rv0623-like transcription factor OGFr_N PF04664.13 ELR24278.1 - 3.9e-48 163.8 3.1 6.2e-48 163.1 3.1 1.3 1 0 0 1 1 1 1 Opioid growth factor receptor (OGFr) conserved region Trypan_PARP PF05887.11 ELR24278.1 - 4.3 7.3 18.5 8.2 6.4 18.5 1.4 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) PLRV_ORF5 PF01690.17 ELR24279.1 - 0.091 11.5 0.0 0.091 11.5 0.0 1.2 1 0 0 1 1 1 0 Potato leaf roll virus readthrough protein ABC_tran PF00005.27 ELR24280.1 - 7.4e-06 26.5 0.8 1.7e-05 25.4 0.1 1.9 2 0 0 2 2 2 1 ABC transporter AAA_23 PF13476.6 ELR24280.1 - 0.00014 22.5 4.7 0.016 15.7 0.0 2.2 2 0 0 2 2 2 2 AAA domain AAA_21 PF13304.6 ELR24280.1 - 0.0023 17.8 0.3 0.0061 16.4 0.0 1.7 2 0 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA PF00004.29 ELR24280.1 - 0.0041 17.6 0.2 0.21 12.0 0.0 2.4 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) NACHT PF05729.12 ELR24280.1 - 0.0083 16.1 0.2 0.024 14.6 0.0 1.8 2 0 0 2 2 2 1 NACHT domain AAA_28 PF13521.6 ELR24280.1 - 0.064 13.5 0.9 0.73 10.1 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_22 PF13401.6 ELR24280.1 - 0.067 13.5 0.1 0.65 10.3 0.0 2.3 2 0 0 2 2 2 0 AAA domain MMR_HSR1 PF01926.23 ELR24280.1 - 0.068 13.3 0.1 0.23 11.6 0.0 1.9 2 1 0 2 2 2 0 50S ribosome-binding GTPase AAA_13 PF13166.6 ELR24280.1 - 0.096 11.3 3.2 0.99 8.0 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_15 PF13175.6 ELR24280.1 - 0.11 12.2 1.4 0.33 10.6 0.0 1.9 2 0 0 2 2 2 0 AAA ATPase domain AAA_29 PF13555.6 ELR24280.1 - 0.12 12.1 0.1 0.32 10.7 0.1 1.8 1 1 0 1 1 1 0 P-loop containing region of AAA domain EMC3_TMCO1 PF01956.16 ELR24280.1 - 0.59 9.9 4.7 0.86 9.3 4.7 1.2 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like DEAD PF00270.29 ELR24281.1 - 7.7e-45 152.8 0.1 1.2e-44 152.1 0.1 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 ELR24281.1 - 5.7e-05 23.2 0.3 0.0002 21.4 0.1 1.9 1 1 1 2 2 2 1 Type III restriction enzyme, res subunit TAF8_C PF10406.9 ELR24281.1 - 1.4 9.5 0.0 1.4 9.5 0.0 2.7 2 1 0 2 2 2 0 Transcription factor TFIID complex subunit 8 C-term Roughex PF06020.11 ELR24281.1 - 6.8 5.7 6.9 12 4.9 6.9 1.3 1 0 0 1 1 1 0 Drosophila roughex protein Helicase_C PF00271.31 ELR24282.1 - 9.3e-32 109.7 0.1 3.4e-31 107.9 0.0 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 ELR24282.1 - 1.2e-17 64.2 0.0 2.1e-17 63.4 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase ERCC3_RAD25_C PF16203.5 ELR24282.1 - 2.4e-07 30.2 0.1 3.3e-07 29.8 0.1 1.2 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase Pyrid_ox_like PF16242.5 ELR24284.1 - 4.1e-30 104.3 0.6 4.8e-30 104.1 0.6 1.1 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase like Putative_PNPOx PF01243.20 ELR24284.1 - 2.3e-08 34.1 0.0 3.6e-08 33.5 0.0 1.3 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase PNK3P PF08645.11 ELR24286.1 - 2.9e-55 186.4 0.0 5.4e-55 185.5 0.0 1.5 1 0 0 1 1 1 1 Polynucleotide kinase 3 phosphatase AAA_33 PF13671.6 ELR24286.1 - 4e-17 62.7 0.0 3.9e-14 53.0 0.0 3.1 2 1 0 2 2 2 1 AAA domain Hydrolase_6 PF13344.6 ELR24286.1 - 0.025 14.7 0.1 0.52 10.4 0.0 2.7 2 1 0 2 2 2 0 Haloacid dehalogenase-like hydrolase Vwaint PF14624.6 ELR24287.1 - 0.067 13.3 5.3 0.35 11.0 0.2 2.5 2 1 0 2 2 2 0 VWA / Hh protein intein-like LRRC37AB_C PF14914.6 ELR24287.1 - 0.17 11.8 2.1 0.33 10.8 2.1 1.5 1 0 0 1 1 1 0 LRRC37A/B like protein 1 C-terminal domain LMBR1 PF04791.16 ELR24287.1 - 0.39 9.6 4.3 0.57 9.0 4.3 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein TMPIT PF07851.13 ELR24287.1 - 1.2 8.3 3.7 1.9 7.7 3.7 1.4 1 0 0 1 1 1 0 TMPIT-like protein SbcD_C PF12320.8 ELR24289.1 - 0.012 15.9 0.1 0.073 13.4 0.1 2.4 1 0 0 1 1 1 0 Type 5 capsule protein repressor C-terminal domain DUF1827 PF08860.10 ELR24289.1 - 0.26 11.5 0.7 0.54 10.5 0.7 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1827) Astro_capsid_N PF03115.14 ELR24290.1 - 0.1 11.2 5.1 0.14 10.8 5.1 1.1 1 0 0 1 1 1 0 Astrovirus capsid protein precursor SRP-alpha_N PF04086.13 ELR24290.1 - 0.7 9.8 14.0 0.94 9.3 14.0 1.2 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal RR_TM4-6 PF06459.12 ELR24290.1 - 3.4 7.4 14.2 7.5 6.3 8.4 2.1 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 tRNA_edit PF04073.15 ELR24291.1 - 1.6e-07 31.5 0.0 7.2e-07 29.3 0.0 2.0 2 1 0 2 2 2 1 Aminoacyl-tRNA editing domain Pkinase PF00069.25 ELR24296.1 - 2.3e-59 200.9 0.0 2.7e-59 200.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR24296.1 - 5.1e-34 117.7 0.0 7e-34 117.3 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ELR24296.1 - 8.7e-08 31.8 0.0 1.4e-07 31.1 0.0 1.3 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 ELR24296.1 - 1.2e-05 25.4 0.1 0.00033 20.7 0.0 2.2 1 1 1 2 2 2 1 Phosphotransferase enzyme family RIO1 PF01163.22 ELR24296.1 - 0.00041 20.0 0.0 0.0006 19.5 0.0 1.3 1 0 0 1 1 1 1 RIO1 family Kdo PF06293.14 ELR24296.1 - 0.0014 18.0 0.0 0.0035 16.7 0.0 1.6 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 ELR24296.1 - 0.0024 16.9 0.0 0.003 16.6 0.0 1.2 1 0 0 1 1 1 1 Haspin like kinase domain Choline_kinase PF01633.20 ELR24296.1 - 0.016 14.8 0.0 0.026 14.1 0.0 1.4 1 0 0 1 1 1 0 Choline/ethanolamine kinase Pox_ser-thr_kin PF05445.11 ELR24296.1 - 0.017 14.1 0.0 0.031 13.2 0.0 1.4 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Seadorna_VP7 PF07387.11 ELR24296.1 - 0.018 14.1 0.0 0.031 13.3 0.0 1.3 1 0 0 1 1 1 0 Seadornavirus VP7 UME PF08064.13 ELR24297.1 - 1.3e-16 60.3 0.0 6.1e-16 58.2 0.0 2.2 2 0 0 2 2 2 1 UME (NUC010) domain FAT PF02259.23 ELR24298.1 - 3.6e-10 39.6 0.0 6.3e-10 38.8 0.0 1.4 1 0 0 1 1 1 1 FAT domain Exo_endo_phos PF03372.23 ELR24300.1 - 2e-13 50.4 4.4 3.3e-13 49.7 4.4 1.4 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.6 ELR24300.1 - 0.069 13.0 0.3 0.24 11.2 0.0 1.9 2 0 0 2 2 2 0 Endonuclease-reverse transcriptase DNA_repr_REX1B PF14966.6 ELR24302.1 - 1.4e-22 80.1 1.4 2.6e-22 79.3 1.4 1.4 1 0 0 1 1 1 1 DNA repair REX1-B COG2 PF06148.11 ELR24302.1 - 0.027 14.5 3.4 0.07 13.2 0.6 2.4 1 1 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 UPF0242 PF06785.11 ELR24302.1 - 0.06 13.5 3.6 0.09 12.9 3.6 1.4 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus FapA PF03961.13 ELR24302.1 - 0.1 11.2 1.0 0.12 10.9 1.0 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A APG6_N PF17675.1 ELR24302.1 - 0.18 12.3 8.5 0.32 11.5 8.1 1.7 1 1 0 1 1 1 0 Apg6 coiled-coil region Jnk-SapK_ap_N PF09744.9 ELR24302.1 - 0.42 10.8 11.0 0.14 12.4 3.6 2.1 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 TMF_TATA_bd PF12325.8 ELR24302.1 - 0.71 10.1 8.3 0.32 11.2 4.9 2.1 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding kleA_kleC PF17383.2 ELR24302.1 - 1.1 9.6 7.8 0.2 12.0 1.9 2.4 2 2 0 2 2 2 0 Uncharacterized KorC regulated protein A AAA_23 PF13476.6 ELR24302.1 - 5.1 7.5 5.6 9.5 6.7 5.6 1.6 1 1 0 1 1 1 0 AAA domain PARP PF00644.20 ELR24303.1 - 4.2e-68 228.8 0.0 4.8e-68 228.6 0.0 1.0 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain DUF4281 PF14108.6 ELR24304.1 - 1.9e-16 60.6 10.5 3.3e-16 59.8 10.5 1.4 1 1 0 1 1 1 1 Domain of unknown function (DUF4281) DUF2834 PF11196.8 ELR24304.1 - 0.063 13.6 1.9 0.1 13.0 0.5 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2834) SAP PF02037.27 ELR24306.1 - 1.2e-25 88.7 5.1 4.9e-14 51.7 0.5 2.2 2 0 0 2 2 2 2 SAP domain HeH PF12949.7 ELR24306.1 - 1.1e-05 25.1 1.8 0.1 12.3 0.1 3.0 2 1 0 2 2 2 2 HeH/LEM domain FANC_SAP PF18081.1 ELR24306.1 - 0.22 11.7 3.3 2.6 8.3 0.2 2.3 2 0 0 2 2 2 0 Fanconi anemia-associated nuclease SAP domain HNF-1_N PF04814.13 ELR24306.1 - 8.1 7.0 14.5 1.1 9.9 10.5 1.5 2 0 0 2 2 2 0 Hepatocyte nuclear factor 1 (HNF-1), N terminus F-box-like PF12937.7 ELR24307.1 - 1.5e-09 37.6 0.2 2.7e-09 36.8 0.2 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ELR24307.1 - 5.1e-06 26.2 0.2 8.6e-06 25.5 0.2 1.4 1 0 0 1 1 1 1 F-box domain F-box_4 PF15966.5 ELR24307.1 - 0.0003 20.6 0.0 0.00057 19.8 0.0 1.5 1 0 0 1 1 1 1 F-box PI3_PI4_kinase PF00454.27 ELR24308.1 - 8.3e-57 192.9 0.0 1e-56 192.6 0.0 1.1 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase FATC PF02260.20 ELR24308.1 - 6e-13 48.4 0.1 9.5e-13 47.7 0.1 1.3 1 0 0 1 1 1 1 FATC domain PARP PF00644.20 ELR24309.1 - 7.8e-32 110.5 0.1 1.8e-31 109.3 0.1 1.7 1 1 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain PARP_reg PF02877.14 ELR24309.1 - 4.1e-14 52.8 0.0 7.6e-14 52.0 0.0 1.4 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase, regulatory domain tRNA_anti-codon PF01336.25 ELR24309.1 - 5.6e-10 39.1 0.0 0.00054 19.9 0.0 2.5 2 0 0 2 2 2 2 OB-fold nucleic acid binding domain REPA_OB_2 PF16900.5 ELR24309.1 - 1.3e-09 37.8 0.1 6.4e-09 35.6 0.0 2.2 2 0 0 2 2 2 1 Replication protein A OB domain BRCT_2 PF16589.5 ELR24309.1 - 1e-07 32.3 0.0 2e-07 31.3 0.0 1.5 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain UDG PF03167.19 ELR24309.1 - 1.3e-07 31.7 0.0 3.7e-07 30.2 0.0 1.8 2 0 0 2 2 2 1 Uracil DNA glycosylase superfamily BRCT PF00533.26 ELR24309.1 - 0.00034 20.9 0.0 0.00086 19.6 0.0 1.8 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain WGR PF05406.15 ELR24309.1 - 0.0035 17.4 0.0 0.0035 17.4 0.0 2.1 2 0 0 2 2 2 1 WGR domain PTCB-BRCT PF12738.7 ELR24309.1 - 0.039 13.9 0.1 0.095 12.7 0.1 1.6 1 0 0 1 1 1 0 twin BRCT domain CagX PF03524.15 ELR24309.1 - 0.21 11.3 1.4 0.39 10.4 0.4 1.9 2 0 0 2 2 2 0 Conjugal transfer protein RasGEF PF00617.19 ELR24313.1 - 2.8e-48 164.5 0.1 5.1e-48 163.6 0.1 1.5 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 ELR24313.1 - 2.6e-22 79.0 1.9 3.6e-22 78.6 0.4 2.0 2 0 0 2 2 2 1 RasGEF N-terminal motif FERM_f0 PF16511.5 ELR24313.1 - 1.2e-13 51.2 0.0 3.3 8.1 0.0 8.4 10 0 0 10 10 10 4 N-terminal or F0 domain of Talin-head FERM ubiquitin PF00240.23 ELR24313.1 - 0.06 13.1 0.0 3.8 7.3 0.0 4.1 5 0 0 5 5 5 0 Ubiquitin family Rad60-SLD PF11976.8 ELR24313.1 - 0.19 11.6 0.0 14 5.6 0.0 3.7 5 0 0 5 5 5 0 Ubiquitin-2 like Rad60 SUMO-like Cu PF17563.2 ELR24313.1 - 1 9.6 3.8 2.7 8.3 3.8 1.6 1 0 0 1 1 1 0 Cupiennin Macoilin PF09726.9 ELR24313.1 - 1.9 7.0 10.2 3.2 6.2 10.2 1.3 1 0 0 1 1 1 0 Macoilin family Med19 PF10278.9 ELR24313.1 - 5.8 6.8 17.7 0.09 12.7 9.9 1.9 2 0 0 2 2 2 0 Mediator of RNA pol II transcription subunit 19 Draxin PF15550.6 ELR24313.1 - 8.6 6.1 13.3 29 4.4 13.3 1.8 1 0 0 1 1 1 0 Draxin Acetyltransf_1 PF00583.25 ELR24314.1 - 8.7e-21 74.3 0.0 1.1e-20 74.0 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 ELR24314.1 - 5.4e-11 42.5 0.0 6.1e-11 42.4 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 ELR24314.1 - 1.1e-10 41.7 0.0 1.5e-10 41.3 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 ELR24314.1 - 1.4e-09 37.8 0.0 2.4e-09 37.0 0.0 1.4 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_3 PF13302.7 ELR24314.1 - 2e-07 31.8 0.0 2.3e-07 31.6 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.6 ELR24314.1 - 1.1e-05 25.1 0.0 1.6e-05 24.6 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 ELR24314.1 - 0.00028 20.9 0.0 0.00043 20.4 0.0 1.5 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 ELR24314.1 - 0.0027 17.9 0.0 0.0033 17.6 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 ELR24314.1 - 0.0051 16.9 0.0 0.0099 16.0 0.0 1.5 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase SAP PF02037.27 ELR24315.1 - 0.012 15.4 0.1 0.047 13.5 0.0 2.1 2 0 0 2 2 2 0 SAP domain V-ATPase_G_2 PF16999.5 ELR24315.1 - 0.041 14.3 5.8 0.09 13.2 5.7 1.8 1 1 0 1 1 1 0 Vacuolar (H+)-ATPase G subunit Rho_N PF07498.12 ELR24315.1 - 1.5 8.8 5.7 0.57 10.1 0.3 2.8 3 1 0 3 3 3 0 Rho termination factor, N-terminal domain AKAP7_NLS PF10469.9 ELR24316.1 - 1.1e-11 45.1 0.0 1.9e-11 44.3 0.0 1.3 1 0 0 1 1 1 1 AKAP7 2'5' RNA ligase-like domain 2_5_RNA_ligase2 PF13563.6 ELR24316.1 - 8.1e-09 35.6 0.1 1.5e-08 34.7 0.1 1.4 1 0 0 1 1 1 1 2'-5' RNA ligase superfamily LigT_PEase PF02834.16 ELR24316.1 - 0.0074 16.4 0.2 3.4 7.9 0.1 2.7 2 1 0 2 2 2 2 LigT like Phosphoesterase Mito_carr PF00153.27 ELR24317.1 - 5.7e-64 212.1 4.9 1.3e-17 63.5 0.2 4.0 3 1 1 4 4 4 4 Mitochondrial carrier protein Fuseless PF15993.5 ELR24317.1 - 0.031 13.5 1.6 0.099 11.8 0.0 2.5 3 1 1 4 4 4 0 Fuseless Transgly_assoc PF04226.13 ELR24317.1 - 0.12 12.7 7.2 1.8 8.9 0.1 3.3 3 0 0 3 3 3 0 Transglycosylase associated protein DUF737 PF05300.11 ELR24318.1 - 0.022 15.1 3.9 0.025 14.9 3.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF737) GET2 PF08690.10 ELR24318.1 - 0.13 11.9 3.4 0.16 11.6 3.4 1.1 1 0 0 1 1 1 0 GET complex subunit GET2 YlqD PF11068.8 ELR24318.1 - 1 9.8 12.4 1.3 9.3 12.4 1.1 1 0 0 1 1 1 0 YlqD protein TFIIA PF03153.13 ELR24318.1 - 1.7 8.6 16.0 2 8.4 16.0 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit V-ATPase_G_2 PF16999.5 ELR24319.1 - 0.0026 18.2 1.6 0.0034 17.8 1.6 1.1 1 0 0 1 1 1 1 Vacuolar (H+)-ATPase G subunit PNPase_C PF12111.8 ELR24320.1 - 0.58 9.6 6.3 0.23 10.9 3.0 2.2 2 0 0 2 2 2 0 Polyribonucleotide phosphorylase C terminal Pkinase PF00069.25 ELR24321.1 - 2.2e-09 37.1 0.0 2.5e-09 36.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR24321.1 - 0.027 13.7 0.0 0.029 13.7 0.0 1.0 1 0 0 1 1 1 0 Protein tyrosine kinase Kinase-like PF14531.6 ELR24321.1 - 0.12 11.7 0.0 0.12 11.7 0.0 1.0 1 0 0 1 1 1 0 Kinase-like Acetyltransf_1 PF00583.25 ELR24322.1 - 9.1e-05 22.7 0.0 0.00012 22.3 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_8 PF13523.6 ELR24322.1 - 0.0033 17.1 0.0 0.0039 16.9 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 ELR24322.1 - 0.0047 16.9 0.0 0.0056 16.6 0.0 1.1 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_3 PF13302.7 ELR24322.1 - 0.088 13.5 0.0 0.1 13.2 0.0 1.1 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain HSP20 PF00011.21 ELR24323.1 - 3.1e-11 43.3 0.0 7.2e-11 42.1 0.0 1.6 1 1 0 1 1 1 1 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 ELR24323.1 - 6.9e-10 38.3 0.0 1.1e-09 37.8 0.0 1.3 1 0 0 1 1 1 1 HSP20-like domain found in ArsA RNR_Alpha PF17975.1 ELR24324.1 - 9.4e-27 93.5 1.3 3.2e-26 91.8 0.9 2.1 2 1 0 2 2 2 1 Ribonucleotide reductase alpha domain Ribonuc_red_lgC PF02867.15 ELR24324.1 - 1.2e-12 47.2 0.0 9.2e-05 21.2 0.0 3.3 3 0 0 3 3 3 3 Ribonucleotide reductase, barrel domain HD PF01966.22 ELR24325.1 - 2.1e-07 31.2 0.7 4.1e-07 30.2 0.7 1.4 1 0 0 1 1 1 1 HD domain FAA_hydrolase_N PF09298.11 ELR24325.1 - 0.00055 20.1 0.3 0.0011 19.1 0.1 1.6 2 0 0 2 2 2 1 Fumarylacetoacetase N-terminal LacI PF00356.21 ELR24325.1 - 0.095 12.5 0.3 0.29 11.0 0.0 2.0 2 0 0 2 2 2 0 Bacterial regulatory proteins, lacI family RhoGEF PF00621.20 ELR24326.1 - 7.9e-49 166.4 0.3 1.6e-48 165.4 0.3 1.5 1 0 0 1 1 1 1 RhoGEF domain PH_13 PF16652.5 ELR24326.1 - 2.4e-05 24.2 0.1 2.4e-05 24.2 0.1 2.5 1 1 2 3 3 3 1 Pleckstrin homology domain IQ_SEC7_PH PF16453.5 ELR24326.1 - 0.0029 17.6 0.1 0.0079 16.2 0.1 1.8 1 0 0 1 1 1 1 PH domain RR_TM4-6 PF06459.12 ELR24326.1 - 0.044 13.6 7.5 0.096 12.5 7.5 1.6 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Connexin PF00029.19 ELR24326.1 - 0.064 13.0 1.8 0.13 12.0 1.8 1.5 1 0 0 1 1 1 0 Connexin ER PF01133.17 ELR24326.1 - 0.1 12.6 0.7 21 5.2 0.2 2.6 2 0 0 2 2 2 0 Enhancer of rudimentary SR-25 PF10500.9 ELR24326.1 - 0.26 10.9 18.9 0.13 11.9 16.6 1.8 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein Gelsolin PF00626.22 ELR24327.1 - 5.9e-28 96.6 0.0 3.4e-06 26.9 0.0 6.7 6 0 0 6 6 6 6 Gelsolin repeat Pkinase_Tyr PF07714.17 ELR24328.1 - 6.3e-57 192.8 0.0 8.3e-57 192.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ELR24328.1 - 1.7e-51 175.1 0.0 2.3e-51 174.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain SAM_PNT PF02198.16 ELR24328.1 - 1.5e-06 28.1 0.1 7.8e-06 25.8 0.0 2.1 2 0 0 2 2 2 1 Sterile alpha motif (SAM)/Pointed domain COR PF16095.5 ELR24328.1 - 2.2e-05 24.4 0.0 4.3e-05 23.4 0.0 1.5 1 0 0 1 1 1 1 C-terminal of Roc, COR, domain SAM_2 PF07647.17 ELR24328.1 - 0.023 14.8 0.0 0.05 13.7 0.0 1.6 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 ELR24328.1 - 0.06 13.8 0.0 0.13 12.8 0.0 1.6 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) EMP24_GP25L PF01105.24 ELR24331.1 - 0.00011 22.3 0.3 0.00013 21.9 0.0 1.3 2 0 0 2 2 2 1 emp24/gp25L/p24 family/GOLD Ras PF00071.22 ELR24332.1 - 1.2e-47 161.5 0.0 1.4e-47 161.4 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR24332.1 - 8.6e-22 77.6 0.0 1.2e-21 77.2 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR24332.1 - 1.2e-07 31.4 0.0 1.8e-07 30.8 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 ELR24332.1 - 0.0017 18.5 0.0 0.0028 17.7 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase SRP-alpha_N PF04086.13 ELR24333.1 - 0.05 13.5 31.9 0.071 13.0 31.9 1.2 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal Mucin PF01456.17 ELR24333.1 - 0.3 11.1 8.6 0.43 10.6 8.6 1.4 1 0 0 1 1 1 0 Mucin-like glycoprotein Draxin PF15550.6 ELR24333.1 - 1.3 8.9 25.6 1.6 8.5 25.6 1.1 1 0 0 1 1 1 0 Draxin PPP4R2 PF09184.11 ELR24333.1 - 2.9 7.4 27.4 3.8 7.0 27.4 1.2 1 0 0 1 1 1 0 PPP4R2 Fer2_3 PF13085.6 ELR24335.1 - 2.9e-34 117.4 0.0 4.9e-34 116.6 0.0 1.4 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain Fer4_8 PF13183.6 ELR24335.1 - 4.8e-09 36.5 23.2 1e-07 32.2 9.7 2.6 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_17 PF13534.6 ELR24335.1 - 8.6e-09 35.8 6.2 8.6e-09 35.8 6.2 2.0 2 0 0 2 2 2 1 4Fe-4S dicluster domain Fer4_10 PF13237.6 ELR24335.1 - 1.7e-07 31.2 4.1 1.7e-07 31.2 4.1 2.1 2 0 0 2 2 2 1 4Fe-4S dicluster domain Fer4_7 PF12838.7 ELR24335.1 - 0.0011 19.5 6.4 0.0011 19.5 6.4 2.7 2 2 0 2 2 2 1 4Fe-4S dicluster domain Fer2 PF00111.27 ELR24335.1 - 0.0033 17.3 0.3 0.0033 17.3 0.3 2.4 2 1 0 2 2 2 1 2Fe-2S iron-sulfur cluster binding domain Fer4_18 PF13746.6 ELR24335.1 - 0.014 15.6 8.2 0.038 14.2 0.2 2.6 3 0 0 3 3 3 0 4Fe-4S dicluster domain Fer4_9 PF13187.6 ELR24335.1 - 0.32 11.2 15.0 0.81 9.9 11.2 2.9 2 1 1 3 3 3 0 4Fe-4S dicluster domain Fer4_16 PF13484.6 ELR24335.1 - 2.1 9.4 14.9 8.7 7.4 11.5 2.9 2 1 1 3 3 3 0 4Fe-4S double cluster binding domain RhoGEF PF00621.20 ELR24336.1 - 9.6e-52 175.9 1.6 1.9e-51 174.9 1.6 1.5 1 0 0 1 1 1 1 RhoGEF domain PH PF00169.29 ELR24336.1 - 2.3e-05 24.8 0.2 4.9e-05 23.8 0.2 1.5 1 0 0 1 1 1 1 PH domain PH_13 PF16652.5 ELR24336.1 - 4.5e-05 23.3 0.2 0.00013 21.8 0.2 1.7 1 0 0 1 1 1 1 Pleckstrin homology domain PH_10 PF15411.6 ELR24336.1 - 0.013 15.8 0.3 0.029 14.7 0.3 1.6 1 0 0 1 1 1 0 Pleckstrin homology domain G_path_suppress PF15991.5 ELR24337.1 - 1 9.4 16.9 1.3 9.0 16.9 1.2 1 0 0 1 1 1 0 G-protein pathway suppressor PH PF00169.29 ELR24338.1 - 9.8e-16 58.2 2.5 2.6e-06 27.9 0.0 3.5 2 1 1 3 3 3 3 PH domain PH_11 PF15413.6 ELR24338.1 - 2.2e-09 37.7 0.0 0.00012 22.4 0.3 2.5 2 0 0 2 2 2 2 Pleckstrin homology domain PH_8 PF15409.6 ELR24338.1 - 1 9.7 10.9 2.6 8.4 0.1 3.7 3 1 1 4 4 4 0 Pleckstrin homology domain F-box PF00646.33 ELR24339.1 - 8.4e-08 31.9 2.9 2.2e-07 30.6 2.9 1.7 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 ELR24339.1 - 1e-07 31.7 1.6 2.2e-07 30.7 1.6 1.6 1 0 0 1 1 1 1 F-box-like Syntaxin PF00804.25 ELR24339.1 - 0.083 12.6 0.1 0.12 12.0 0.1 1.2 1 0 0 1 1 1 0 Syntaxin Hat1_N PF10394.9 ELR24340.1 - 6.2e-29 101.3 0.0 1e-28 100.6 0.0 1.4 1 0 0 1 1 1 1 Histone acetyl transferase HAT1 N-terminus Acetyltransf_1 PF00583.25 ELR24340.1 - 7.9e-06 26.1 0.0 1.5e-05 25.2 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 ELR24340.1 - 0.009 16.4 0.0 0.017 15.5 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain MOZ_SAS PF01853.18 ELR24340.1 - 0.024 14.3 0.0 0.039 13.6 0.0 1.2 1 0 0 1 1 1 0 MOZ/SAS family Syntaxin PF00804.25 ELR24340.1 - 0.18 11.5 0.1 0.28 10.8 0.1 1.2 1 0 0 1 1 1 0 Syntaxin WD40 PF00400.32 ELR24341.1 - 4.6e-19 68.4 15.0 0.00031 21.5 0.0 6.9 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ELR24341.1 - 5.3e-07 29.8 0.2 0.015 15.6 0.0 4.8 2 1 3 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ELR24341.1 - 0.0019 16.9 3.6 0.013 14.2 1.2 2.6 1 1 0 2 2 2 1 Nucleoporin Nup120/160 WD40_like PF17005.5 ELR24341.1 - 0.0055 16.1 0.0 3 7.1 0.0 3.0 2 2 1 3 3 3 1 WD40-like domain Gmad1 PF10647.9 ELR24341.1 - 0.02 14.6 2.6 0.11 12.3 0.4 2.5 1 1 1 2 2 2 0 Lipoprotein LpqB beta-propeller domain PQQ_3 PF13570.6 ELR24341.1 - 0.027 15.0 3.3 12 6.5 0.0 4.6 5 1 0 5 5 5 0 PQQ-like domain FeThRed_A PF02941.15 ELR24341.1 - 0.15 12.2 0.0 0.32 11.2 0.0 1.5 1 0 0 1 1 1 0 Ferredoxin thioredoxin reductase variable alpha chain Pkinase PF00069.25 ELR24342.1 - 3.1e-64 216.9 0.0 3.1e-64 216.9 0.0 1.7 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR24342.1 - 4e-48 164.0 0.0 7.6e-48 163.0 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 ELR24342.1 - 9.2e-05 21.4 0.0 9.2e-05 21.4 0.0 2.5 2 1 0 2 2 2 1 Fungal protein kinase Kinase-like PF14531.6 ELR24342.1 - 0.0024 17.3 0.0 0.018 14.4 0.0 2.1 2 0 0 2 2 2 1 Kinase-like DSHCT PF08148.12 ELR24342.1 - 0.0058 16.3 1.2 0.025 14.2 0.0 2.4 2 1 0 2 2 2 1 DSHCT (NUC185) domain Alpha-amylase PF00128.24 ELR24343.1 - 8.2e-10 38.7 0.0 1.4e-08 34.7 0.0 2.2 1 1 0 1 1 1 1 Alpha amylase, catalytic domain Cmc1 PF08583.10 ELR24344.1 - 5.5e-12 45.5 1.6 1e-11 44.7 1.6 1.5 1 0 0 1 1 1 1 Cytochrome c oxidase biogenesis protein Cmc1 like LANC_like PF05147.13 ELR24344.1 - 0.019 13.5 0.0 0.029 13.0 0.0 1.3 1 0 0 1 1 1 0 Lanthionine synthetase C-like protein NDUF_B7 PF05676.13 ELR24344.1 - 0.027 14.2 1.2 0.059 13.1 1.2 1.6 1 0 0 1 1 1 0 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) Cytochrom_B561 PF03188.16 ELR24345.1 - 1.6e-32 112.5 3.9 2.7e-32 111.8 3.9 1.3 1 0 0 1 1 1 1 Eukaryotic cytochrome b561 7TM_GPCR_Str PF10326.9 ELR24345.1 - 0.043 13.2 0.0 0.094 12.0 0.0 1.6 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Str DUF4079 PF13301.6 ELR24345.1 - 0.16 12.1 7.4 7.8 6.6 2.7 3.2 3 1 0 3 3 3 0 Protein of unknown function (DUF4079) DUF2427 PF10348.9 ELR24345.1 - 4 7.3 10.7 0.15 11.9 3.5 2.2 2 2 0 2 2 2 0 Domain of unknown function (DUF2427) Pkr1 PF08636.10 ELR24346.1 - 5.4e-06 26.5 0.7 7.3e-06 26.0 0.7 1.2 1 0 0 1 1 1 1 ER protein Pkr1 Trypan_PARP PF05887.11 ELR24346.1 - 0.00046 20.2 0.4 0.00061 19.8 0.4 1.3 1 0 0 1 1 1 1 Procyclic acidic repetitive protein (PARP) Scs3p PF10261.9 ELR24346.1 - 0.0035 16.9 0.1 0.0044 16.6 0.1 1.2 1 0 0 1 1 1 1 Inositol phospholipid synthesis and fat-storage-inducing TM CLN3 PF02487.17 ELR24346.1 - 0.0071 15.4 0.1 0.0078 15.3 0.1 1.0 1 0 0 1 1 1 1 CLN3 protein DUF4131 PF13567.6 ELR24346.1 - 0.011 15.4 0.0 0.013 15.2 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) O-antigen_lig PF13425.6 ELR24346.1 - 0.025 13.4 0.0 0.027 13.3 0.0 1.0 1 0 0 1 1 1 0 O-antigen ligase like membrane protein DUF4834 PF16118.5 ELR24346.1 - 0.17 12.8 3.1 0.31 12.0 3.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) CPSF100_C PF13299.6 ELR24346.1 - 0.19 11.9 6.7 0.24 11.6 6.7 1.1 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Connexin PF00029.19 ELR24346.1 - 2.1 8.0 3.5 2.7 7.7 3.5 1.2 1 0 0 1 1 1 0 Connexin Presenilin PF01080.17 ELR24346.1 - 5.8 5.6 5.9 7.1 5.3 5.9 1.1 1 0 0 1 1 1 0 Presenilin Arm PF00514.23 ELR24347.1 - 4.7e-28 96.3 72.2 0.0012 18.8 0.4 20.5 21 0 0 21 21 21 10 Armadillo/beta-catenin-like repeat WW PF00397.26 ELR24347.1 - 6.9e-11 42.0 4.7 7.3e-11 42.0 1.5 2.2 2 0 0 2 2 2 1 WW domain Adaptin_N PF01602.20 ELR24347.1 - 5.8e-05 21.8 0.6 0.34 9.4 0.0 4.1 4 0 0 4 4 4 2 Adaptin N terminal region Arm_2 PF04826.13 ELR24347.1 - 0.0011 18.5 0.0 12 5.3 0.0 4.3 5 0 0 5 5 5 2 Armadillo-like Cnd1 PF12717.7 ELR24347.1 - 0.024 14.7 0.0 77 3.3 0.0 4.5 5 0 0 5 5 5 0 non-SMC mitotic condensation complex subunit 1 RTP1_C1 PF10363.9 ELR24347.1 - 0.16 12.1 0.4 7.5 6.8 0.2 3.5 3 0 0 3 3 3 0 Required for nuclear transport of RNA pol II C-terminus 1 HEAT_2 PF13646.6 ELR24347.1 - 2.6 8.5 69.2 0.032 14.6 3.7 11.8 7 5 4 11 11 11 0 HEAT repeats BTB PF00651.31 ELR24348.1 - 6.3e-21 74.7 0.2 1.2e-20 73.8 0.2 1.5 1 0 0 1 1 1 1 BTB/POZ domain Ank_2 PF12796.7 ELR24348.1 - 7.6e-08 32.8 0.1 0.00014 22.4 0.0 3.4 3 0 0 3 3 3 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ELR24348.1 - 6.4e-07 29.8 0.1 5.8e-05 23.6 0.0 3.0 3 0 0 3 3 3 1 Ankyrin repeats (many copies) Ank_5 PF13857.6 ELR24348.1 - 1.3e-06 28.6 0.4 0.00055 20.2 0.0 3.3 3 0 0 3 3 3 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 ELR24348.1 - 3.8e-05 23.7 0.8 0.0022 18.3 0.0 3.8 3 0 0 3 3 3 1 Ankyrin repeat Ank PF00023.30 ELR24348.1 - 3.9e-05 23.9 0.1 0.00092 19.6 0.0 3.4 3 0 0 3 3 3 1 Ankyrin repeat DUF2520 PF10728.9 ELR24348.1 - 0.077 12.8 0.2 2.2 8.1 0.1 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF2520) PRIMA1 PF16101.5 ELR24348.1 - 0.46 10.5 4.2 1.8 8.6 4.2 2.0 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 TFIIF_beta_N PF17683.1 ELR24349.1 - 0.037 14.7 0.1 0.099 13.3 0.0 1.7 2 0 0 2 2 2 0 TFIIF, beta subunit N-terminus VWA_2 PF13519.6 ELR24350.1 - 1.2e-10 41.9 0.0 5.7e-10 39.8 0.0 2.0 2 0 0 2 2 2 1 von Willebrand factor type A domain VWA PF00092.28 ELR24350.1 - 0.0038 17.5 0.0 0.0063 16.8 0.0 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain SR-25 PF10500.9 ELR24350.1 - 0.39 10.3 6.5 0.68 9.5 6.5 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein XRCC4 PF06632.12 ELR24352.1 - 0.17 10.7 5.5 0.19 10.6 5.5 1.0 1 0 0 1 1 1 0 DNA double-strand break repair and V(D)J recombination protein XRCC4 CDC27 PF09507.10 ELR24352.1 - 0.87 8.9 12.0 0.97 8.8 12.0 1.0 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 FAM176 PF14851.6 ELR24352.1 - 1.4 8.6 5.9 1.7 8.3 5.9 1.1 1 0 0 1 1 1 0 FAM176 family CDC45 PF02724.14 ELR24352.1 - 2.3 6.4 10.7 2.5 6.3 10.7 1.0 1 0 0 1 1 1 0 CDC45-like protein GCS PF03074.16 ELR24354.1 - 7.5e-143 476.3 0.0 1.1e-142 475.7 0.0 1.2 1 0 0 1 1 1 1 Glutamate-cysteine ligase GCS PF03074.16 ELR24356.1 - 2.5e-29 102.8 0.2 2.8e-29 102.6 0.2 1.0 1 0 0 1 1 1 1 Glutamate-cysteine ligase RB_A PF01858.17 ELR24357.1 - 1.4e-56 191.5 0.0 3.6e-56 190.1 0.0 1.8 1 0 0 1 1 1 1 Retinoblastoma-associated protein A domain RB_B PF01857.20 ELR24357.1 - 2.5e-30 105.2 0.0 1.1e-27 96.6 0.0 2.8 2 0 0 2 2 2 2 Retinoblastoma-associated protein B domain DUF3452 PF11934.8 ELR24357.1 - 1.3e-29 102.5 0.1 7.2e-29 100.1 0.0 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF3452) UNC-50 PF05216.13 ELR24358.1 - 4.6e-67 225.8 25.8 3.6e-66 222.9 25.8 1.9 1 1 0 1 1 1 1 UNC-50 family DUF983 PF06170.12 ELR24358.1 - 9.8 6.7 15.3 0.06 13.8 1.9 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF983) HRI1 PF16815.5 ELR24359.1 - 0.00031 20.5 0.0 0.00057 19.7 0.0 1.3 1 0 0 1 1 1 1 Protein HRI1 Amidohydro_1 PF01979.20 ELR24360.1 - 2.2e-20 73.3 2.5 2.7e-11 43.4 0.0 3.3 3 0 0 3 3 3 3 Amidohydrolase family Amidohydro_3 PF07969.11 ELR24360.1 - 2.3e-19 70.2 5.7 1.1e-10 41.6 0.1 3.4 3 0 0 3 3 3 3 Amidohydrolase family AMP-binding PF00501.28 ELR24361.1 - 2.3e-63 214.3 0.0 3.9e-63 213.5 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme Exo_endo_phos PF03372.23 ELR24361.1 - 4.5e-09 36.2 0.0 1.6e-08 34.4 0.0 2.0 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family NOA36 PF06524.12 ELR24361.1 - 8 5.7 6.9 13 5.0 6.9 1.2 1 0 0 1 1 1 0 NOA36 protein GST_N PF02798.20 ELR24362.1 - 3.7e-15 56.0 0.1 9.8e-15 54.7 0.0 1.7 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 ELR24362.1 - 7e-14 52.0 0.0 1.3e-13 51.1 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 ELR24362.1 - 3.5e-11 43.3 0.0 6e-11 42.5 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 ELR24362.1 - 4.3e-06 26.8 0.0 8.9e-06 25.8 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 ELR24362.1 - 0.00073 19.5 0.0 0.0014 18.6 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Tom37 PF10568.9 ELR24362.1 - 0.001 19.3 0.0 0.2 12.0 0.0 2.2 2 0 0 2 2 2 2 Outer mitochondrial membrane transport complex protein GST_C_3 PF14497.6 ELR24362.1 - 0.065 13.4 0.1 0.12 12.6 0.1 1.5 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain BTG PF07742.12 ELR24363.1 - 5.5e-11 42.3 0.0 8e-11 41.8 0.0 1.2 1 0 0 1 1 1 1 BTG family Pkinase_Tyr PF07714.17 ELR24364.1 - 6.2e-123 409.1 0.0 1.3e-60 204.9 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 ELR24364.1 - 6.1e-103 343.8 0.0 2e-50 171.6 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Guanylate_cyc PF00211.20 ELR24364.1 - 1.6e-08 34.4 0.0 3e-08 33.5 0.0 1.4 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain PBP_like_2 PF12849.7 ELR24364.1 - 3.7e-07 30.1 0.2 0.00087 19.0 0.0 2.4 2 0 0 2 2 2 2 PBP superfamily domain APH PF01636.23 ELR24364.1 - 2.8e-06 27.4 0.6 0.0025 17.8 0.1 3.2 2 1 0 3 3 3 2 Phosphotransferase enzyme family Haspin_kinase PF12330.8 ELR24364.1 - 5.6e-05 22.3 1.3 0.018 14.0 0.1 3.1 3 0 0 3 3 3 1 Haspin like kinase domain TMEM154 PF15102.6 ELR24364.1 - 0.0038 17.1 0.0 0.0094 15.9 0.0 1.6 1 0 0 1 1 1 1 TMEM154 protein family FTA2 PF13095.6 ELR24364.1 - 0.0067 16.1 0.0 0.33 10.6 0.0 2.6 2 1 0 2 2 2 1 Kinetochore Sim4 complex subunit FTA2 RIO1 PF01163.22 ELR24364.1 - 0.0076 15.9 0.6 0.64 9.6 0.1 2.4 2 0 0 2 2 2 1 RIO1 family Kinase-like PF14531.6 ELR24364.1 - 0.0088 15.4 0.0 0.8 9.0 0.0 2.3 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.14 ELR24364.1 - 0.019 14.3 0.5 4.7 6.5 0.0 2.3 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family Osteopontin PF00865.18 ELR24364.1 - 0.64 9.5 16.0 0.66 9.4 0.5 2.2 2 0 0 2 2 2 0 Osteopontin Pkinase_Tyr PF07714.17 ELR24365.1 - 2.3e-47 161.5 0.0 3.2e-47 161.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ELR24365.1 - 5.7e-37 127.5 0.0 9.4e-37 126.8 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Kinase-like PF14531.6 ELR24365.1 - 0.061 12.6 0.0 0.12 11.6 0.0 1.5 2 0 0 2 2 2 0 Kinase-like FTA2 PF13095.6 ELR24365.1 - 0.084 12.5 0.0 0.15 11.7 0.0 1.3 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 RIO1 PF01163.22 ELR24365.1 - 0.23 11.1 0.0 0.23 11.1 0.0 1.5 2 0 0 2 2 2 0 RIO1 family SDA1 PF05285.12 ELR24365.1 - 0.44 9.9 10.5 0.63 9.4 10.5 1.1 1 0 0 1 1 1 0 SDA1 Ldh_1_N PF00056.23 ELR24366.1 - 2.2e-35 121.8 0.0 3.3e-35 121.2 0.0 1.3 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain Ldh_1_C PF02866.18 ELR24366.1 - 2.1e-30 105.9 0.0 5.5e-30 104.5 0.0 1.7 2 0 0 2 2 2 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain FAD-SLDH PF12318.8 ELR24367.1 - 0.11 12.6 0.4 1.1 9.3 0.0 2.9 3 0 0 3 3 3 0 Membrane bound FAD containing D-sorbitol dehydrogenase SPO22 PF08631.10 ELR24367.1 - 0.56 9.6 3.3 4 6.9 0.1 3.1 3 1 1 4 4 4 0 Meiosis protein SPO22/ZIP4 like Peptidase_A22B PF04258.13 ELR24368.1 - 1.3e-55 189.0 7.1 1.6e-55 188.7 7.1 1.1 1 0 0 1 1 1 1 Signal peptide peptidase Mito_morph_reg PF14972.6 ELR24368.1 - 0.18 11.4 1.1 0.24 11.0 0.5 1.6 1 1 0 1 1 1 0 Mitochondrial morphogenesis regulator WD40 PF00400.32 ELR24369.1 - 7.1e-14 52.0 21.9 0.0016 19.2 0.0 8.8 9 2 0 9 9 9 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ELR24369.1 - 5e-08 33.1 2.7 0.99 9.7 0.1 6.9 5 2 2 7 7 7 3 Anaphase-promoting complex subunit 4 WD40 domain Hira PF07569.11 ELR24369.1 - 0.016 15.0 0.1 1.8 8.3 0.0 3.0 4 0 0 4 4 4 0 TUP1-like enhancer of split LigD_N PF13298.6 ELR24369.1 - 0.15 12.3 0.1 27 5.1 0.0 3.3 3 0 0 3 3 3 0 DNA polymerase Ligase (LigD) Ge1_WD40 PF16529.5 ELR24369.1 - 0.67 8.9 2.1 23 3.8 2.6 2.8 2 1 0 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Laminin_G_3 PF13385.6 ELR24370.1 - 0.0086 16.2 0.0 0.022 14.9 0.0 1.7 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily PH PF00169.29 ELR24372.1 - 1.9e-18 66.9 0.1 6.4e-18 65.2 0.1 2.0 1 0 0 1 1 1 1 PH domain AMPK1_CBM PF16561.5 ELR24372.1 - 4.1e-05 23.7 0.1 0.0018 18.4 0.0 2.5 2 0 0 2 2 2 1 Glycogen recognition site of AMP-activated protein kinase PH_11 PF15413.6 ELR24372.1 - 8.6e-05 22.9 0.4 0.0017 18.7 0.4 2.8 1 1 0 1 1 1 1 Pleckstrin homology domain PH_9 PF15410.6 ELR24372.1 - 0.0021 18.4 0.1 0.03 14.7 0.1 2.4 1 1 0 1 1 1 1 Pleckstrin homology domain PH_3 PF14593.6 ELR24372.1 - 0.0023 18.0 0.0 0.0049 16.9 0.0 1.6 1 0 0 1 1 1 1 PH domain PH_6 PF15406.6 ELR24372.1 - 0.051 13.9 0.0 0.051 13.9 0.0 2.5 3 0 0 3 3 3 0 Pleckstrin homology domain PB1 PF00564.24 ELR24373.1 - 5.7e-07 29.4 0.1 1.1e-06 28.4 0.1 1.4 1 0 0 1 1 1 1 PB1 domain MMR_HSR1 PF01926.23 ELR24376.1 - 2.5e-10 40.4 0.2 7.1e-10 39.0 0.2 1.8 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 ELR24376.1 - 1.1e-06 28.2 0.4 0.0059 16.2 0.4 2.4 2 0 0 2 2 2 2 Ferrous iron transport protein B RsgA_GTPase PF03193.16 ELR24376.1 - 1.1e-05 25.4 0.1 0.00012 22.1 0.1 2.2 2 0 0 2 2 2 1 RsgA GTPase Roc PF08477.13 ELR24376.1 - 6.7e-05 23.1 0.0 0.096 12.9 0.0 2.5 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 ELR24376.1 - 0.015 14.9 0.0 4.9 6.7 0.0 2.3 2 0 0 2 2 2 0 Ras family GTP_EFTU PF00009.27 ELR24376.1 - 0.022 14.3 0.0 4.1 6.9 0.1 2.4 1 1 1 2 2 2 0 Elongation factor Tu GTP binding domain Dynamin_N PF00350.23 ELR24376.1 - 0.042 13.9 1.2 0.53 10.3 0.0 2.8 3 1 1 4 4 4 0 Dynamin family Arf PF00025.21 ELR24376.1 - 0.18 11.3 0.2 1.1 8.7 0.1 2.3 1 1 1 2 2 2 0 ADP-ribosylation factor family Lin-8 PF03353.15 ELR24376.1 - 5.3 6.5 7.0 11 5.5 7.0 1.4 1 1 0 1 1 1 0 Ras-mediated vulval-induction antagonist CDC45 PF02724.14 ELR24376.1 - 8.6 4.5 17.7 33 2.6 0.0 2.0 2 0 0 2 2 2 0 CDC45-like protein Alpha-amylase_C PF02806.18 ELR24377.1 - 5.1e-24 84.6 0.0 1.4e-23 83.2 0.0 1.8 1 0 0 1 1 1 1 Alpha amylase, C-terminal all-beta domain CBM_48 PF02922.18 ELR24377.1 - 8.7e-17 61.3 0.1 3.1e-16 59.5 0.1 2.0 1 0 0 1 1 1 1 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) Alpha-amylase PF00128.24 ELR24377.1 - 9.1e-08 32.0 1.0 1.3e-06 28.2 0.1 2.4 1 1 0 2 2 2 1 Alpha amylase, catalytic domain AMPK1_CBM PF16561.5 ELR24377.1 - 0.0052 17.0 0.1 0.018 15.2 0.1 1.9 1 0 0 1 1 1 1 Glycogen recognition site of AMP-activated protein kinase EF-hand_7 PF13499.6 ELR24378.1 - 1.4e-05 25.4 0.2 5.9e-05 23.4 0.0 2.1 2 1 0 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.6 ELR24378.1 - 0.00038 20.2 0.9 3.4 7.8 0.0 3.4 3 0 0 3 3 3 2 EF-hand domain SPX PF03105.19 ELR24378.1 - 0.0029 17.6 1.7 0.0042 17.1 1.7 1.2 1 0 0 1 1 1 1 SPX domain EF-hand_1 PF00036.32 ELR24378.1 - 0.0061 16.0 1.1 1.8 8.3 0.0 3.3 3 0 0 3 3 3 1 EF hand EF-hand_9 PF14658.6 ELR24378.1 - 0.06 13.7 0.0 12 6.3 0.0 2.4 1 1 1 2 2 2 0 EF-hand domain dsrm PF00035.26 ELR24379.1 - 9.4e-06 26.2 1.6 1e-05 26.2 0.0 1.8 2 0 0 2 2 2 1 Double-stranded RNA binding motif zf-CCHH PF10283.9 ELR24379.1 - 0.01 15.8 0.4 0.023 14.7 0.4 1.7 1 0 0 1 1 1 0 PBZ domain WW PF00397.26 ELR24379.1 - 0.27 11.4 1.7 1.7 8.8 0.2 2.9 2 1 0 2 2 2 0 WW domain Cyclin_C PF02984.19 ELR24380.1 - 7.5e-18 64.7 0.0 2.8e-17 62.9 0.0 2.0 2 0 0 2 2 2 1 Cyclin, C-terminal domain Cyclin_N PF00134.23 ELR24380.1 - 1.1e-17 63.9 0.4 2.6e-17 62.8 0.1 1.7 2 0 0 2 2 2 1 Cyclin, N-terminal domain PTS_2-RNA PF01885.16 ELR24383.1 - 4.6e-60 202.8 0.0 5.3e-60 202.6 0.0 1.0 1 0 0 1 1 1 1 RNA 2'-phosphotransferase, Tpt1 / KptA family 2OG-FeII_Oxy_2 PF13532.6 ELR24384.1 - 2.3e-26 93.2 0.0 2.8e-26 92.9 0.0 1.1 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Metallophos PF00149.28 ELR24387.1 - 1.7e-17 64.6 0.5 2.5e-17 64.0 0.5 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_C PF14008.6 ELR24387.1 - 2.3e-16 60.4 0.3 5.7e-16 59.1 0.3 1.7 1 0 0 1 1 1 1 Iron/zinc purple acid phosphatase-like protein C Pur_ac_phosph_N PF16656.5 ELR24387.1 - 5.6e-07 30.0 0.4 1.7e-06 28.5 0.4 1.8 1 1 0 1 1 1 1 Purple acid Phosphatase, N-terminal domain Phage_Coat_B PF05356.11 ELR24388.1 - 0.025 14.5 4.4 0.032 14.1 0.3 2.9 3 0 0 3 3 3 0 Phage Coat protein B DUF5620 PF18522.1 ELR24388.1 - 0.054 13.9 0.1 0.14 12.6 0.1 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF5620) DUF5317 PF17248.2 ELR24388.1 - 0.081 12.9 0.0 0.18 11.8 0.0 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5317) ABC2_membrane PF01061.24 ELR24389.1 - 2.6e-44 151.2 13.6 2.6e-44 151.2 13.6 1.9 2 0 0 2 2 2 1 ABC-2 type transporter ABC_tran PF00005.27 ELR24389.1 - 5.8e-29 101.4 0.0 1e-28 100.6 0.0 1.4 1 0 0 1 1 1 1 ABC transporter RsgA_GTPase PF03193.16 ELR24389.1 - 5.6e-06 26.4 0.1 1e-05 25.5 0.1 1.3 1 0 0 1 1 1 1 RsgA GTPase AAA_21 PF13304.6 ELR24389.1 - 0.00013 21.9 0.9 0.096 12.5 0.2 2.6 1 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_25 PF13481.6 ELR24389.1 - 0.00044 19.9 0.0 0.0018 17.9 0.0 2.0 2 0 0 2 2 2 1 AAA domain ABC2_membrane_3 PF12698.7 ELR24389.1 - 0.00059 19.1 11.5 0.00092 18.4 11.5 1.3 1 0 0 1 1 1 1 ABC-2 family transporter protein ABC2_membrane_2 PF12679.7 ELR24389.1 - 0.00087 18.6 3.3 0.0017 17.7 3.3 1.5 1 0 0 1 1 1 1 ABC-2 family transporter protein AAA_29 PF13555.6 ELR24389.1 - 0.0059 16.3 0.2 0.016 14.9 0.1 1.7 1 1 0 1 1 1 1 P-loop containing region of AAA domain AAA_16 PF13191.6 ELR24389.1 - 0.0083 16.5 0.0 0.018 15.4 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain SMC_N PF02463.19 ELR24389.1 - 0.011 15.2 0.0 2.4 7.5 0.0 2.2 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 ELR24389.1 - 0.011 16.2 5.2 0.017 15.7 0.2 2.7 1 1 2 3 3 3 0 AAA domain AAA_22 PF13401.6 ELR24389.1 - 0.013 15.8 0.0 0.031 14.5 0.0 1.6 1 0 0 1 1 1 0 AAA domain cobW PF02492.19 ELR24389.1 - 0.014 14.9 0.1 0.023 14.3 0.1 1.2 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain MMR_HSR1 PF01926.23 ELR24389.1 - 0.031 14.4 0.1 0.073 13.2 0.1 1.6 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_18 PF13238.6 ELR24389.1 - 0.04 14.5 0.0 0.09 13.3 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.6 ELR24389.1 - 0.046 13.5 0.0 0.1 12.3 0.0 1.6 2 0 0 2 2 1 0 AAA domain NACHT PF05729.12 ELR24389.1 - 0.052 13.5 0.1 0.15 12.0 0.0 1.8 2 0 0 2 2 1 0 NACHT domain AAA_28 PF13521.6 ELR24389.1 - 0.053 13.8 0.1 0.11 12.7 0.1 1.5 1 0 0 1 1 1 0 AAA domain Dynactin PF12455.8 ELR24389.1 - 0.057 12.6 0.0 0.1 11.8 0.0 1.3 1 0 0 1 1 1 0 Dynein associated protein AAA_30 PF13604.6 ELR24389.1 - 0.15 11.8 0.2 0.28 10.9 0.2 1.3 1 0 0 1 1 1 0 AAA domain PduV-EutP PF10662.9 ELR24389.1 - 0.15 11.8 0.0 0.28 10.9 0.0 1.4 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation Pkinase PF00069.25 ELR24391.1 - 9.1e-68 228.5 0.0 1.1e-67 228.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR24391.1 - 4.5e-37 127.8 0.0 5.5e-37 127.5 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ELR24391.1 - 4.5e-12 45.9 0.0 6.1e-12 45.4 0.0 1.2 1 0 0 1 1 1 1 Kinase-like YrbL-PhoP_reg PF10707.9 ELR24391.1 - 4.4e-05 23.1 0.0 0.00049 19.7 0.1 2.4 2 1 0 2 2 2 1 PhoP regulatory network protein YrbL RIO1 PF01163.22 ELR24391.1 - 7e-05 22.5 0.2 0.057 13.0 0.0 2.2 1 1 1 2 2 2 2 RIO1 family Kdo PF06293.14 ELR24391.1 - 7.1e-05 22.2 0.0 0.00011 21.7 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 ELR24391.1 - 0.00021 21.3 0.0 0.00034 20.6 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 ELR24391.1 - 0.0019 17.2 0.0 0.0025 16.8 0.0 1.2 1 0 0 1 1 1 1 Haspin like kinase domain ABC1 PF03109.16 ELR24391.1 - 0.0089 16.2 0.0 0.019 15.2 0.0 1.6 1 0 0 1 1 1 1 ABC1 family Pkinase_fungal PF17667.1 ELR24391.1 - 0.022 13.6 0.0 0.054 12.3 0.0 1.6 1 1 0 1 1 1 0 Fungal protein kinase UPF0183 PF03676.14 ELR24392.1 - 3.7e-95 319.5 0.0 4.8e-95 319.1 0.0 1.1 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0183) BAF1_ABF1 PF04684.13 ELR24392.1 - 0.013 14.5 3.3 0.016 14.3 3.3 1.1 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor CRISPR_Cse2 PF09485.10 ELR24392.1 - 0.12 12.9 0.9 0.76 10.3 0.6 2.1 2 0 0 2 2 2 0 CRISPR-associated protein Cse2 (CRISPR_cse2) Herpes_DNAp_acc PF04929.12 ELR24392.1 - 0.21 10.6 2.0 0.3 10.0 2.0 1.1 1 0 0 1 1 1 0 Herpes DNA replication accessory factor CPBP PF02517.16 ELR24393.1 - 8.7e-18 64.5 6.7 8.7e-18 64.5 6.7 2.7 4 1 0 4 4 4 1 CPBP intramembrane metalloprotease Abhydrolase_9_N PF15420.6 ELR24393.1 - 0.63 10.0 3.9 0.28 11.2 1.5 1.6 2 0 0 2 2 2 0 Alpha/beta-hydrolase family N-terminus CoA_transf_3 PF02515.17 ELR24394.1 - 3.4e-52 177.8 0.4 3.4e-26 92.2 0.0 2.2 1 1 1 2 2 2 2 CoA-transferase family III F-box-like PF12937.7 ELR24395.1 - 3.7e-09 36.3 2.3 1.2e-07 31.5 0.8 2.9 3 1 0 3 3 3 1 F-box-like F-box PF00646.33 ELR24395.1 - 0.0025 17.6 0.2 0.0084 16.0 0.1 1.9 1 1 1 2 2 2 1 F-box domain Elongin_A PF06881.11 ELR24395.1 - 0.013 16.0 0.3 0.013 16.0 0.3 1.7 2 0 0 2 2 2 0 RNA polymerase II transcription factor SIII (Elongin) subunit A Pkinase_Tyr PF07714.17 ELR24396.1 - 9.6e-68 228.3 0.0 4e-63 213.1 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 ELR24396.1 - 1.1e-55 188.8 0.0 2.1e-53 181.4 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain PBP_like_2 PF12849.7 ELR24396.1 - 8.1e-29 101.2 5.4 4.8e-21 75.7 1.0 2.4 2 0 0 2 2 2 2 PBP superfamily domain Guanylate_cyc PF00211.20 ELR24396.1 - 5.2e-15 55.5 0.0 1e-14 54.6 0.0 1.5 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain APH PF01636.23 ELR24396.1 - 3.1e-05 24.0 0.0 9e-05 22.5 0.0 1.8 1 0 0 1 1 1 1 Phosphotransferase enzyme family EGF_2 PF07974.13 ELR24396.1 - 0.0014 19.0 8.3 0.0029 17.9 8.3 1.6 1 0 0 1 1 1 1 EGF-like domain Haspin_kinase PF12330.8 ELR24396.1 - 0.0081 15.1 0.0 0.018 14.0 0.0 1.5 1 0 0 1 1 1 1 Haspin like kinase domain EGF_Tenascin PF18720.1 ELR24396.1 - 0.1 12.7 5.2 0.24 11.5 5.2 1.6 1 0 0 1 1 1 0 Tenascin EGF domain EGF PF00008.27 ELR24396.1 - 0.15 12.4 4.8 0.29 11.5 4.8 1.5 1 0 0 1 1 1 0 EGF-like domain hEGF PF12661.7 ELR24396.1 - 2 9.2 3.7 4.6 8.0 3.7 1.7 1 0 0 1 1 1 0 Human growth factor-like EGF Laminin_EGF PF00053.24 ELR24396.1 - 8.6 6.6 6.5 18 5.6 6.5 1.5 1 0 0 1 1 1 0 Laminin EGF domain Vfa1 PF08432.10 ELR24397.1 - 0.096 13.0 5.1 0.14 12.5 5.1 1.2 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 DUF913 PF06025.12 ELR24397.1 - 0.56 9.1 1.7 0.77 8.7 1.7 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) DUF3292 PF11696.8 ELR24397.1 - 0.58 8.5 4.7 0.78 8.0 4.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3292) DUF3530 PF12048.8 ELR24397.1 - 0.76 9.1 5.1 5.6 6.3 5.1 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF3530) DAGAT PF03982.13 ELR24399.1 - 2.5e-63 213.8 0.0 3.1e-63 213.4 0.0 1.0 1 0 0 1 1 1 1 Diacylglycerol acyltransferase Cofilin_ADF PF00241.20 ELR24400.1 - 4.9e-06 26.3 0.0 2.7e-05 24.0 0.0 2.1 1 1 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein Helicase_Sgs1 PF11408.8 ELR24400.1 - 0.19 11.8 0.2 2.7 8.1 0.1 2.2 2 0 0 2 2 2 0 Sgs1 RecQ helicase FPN1 PF06963.12 ELR24401.1 - 1.1e-74 251.6 22.6 9.8e-38 129.8 2.0 2.8 1 1 1 2 2 2 2 Ferroportin1 (FPN1) Holin_9 PF16936.5 ELR24401.1 - 1.5 9.1 0.0 1.5 9.1 0.0 4.0 4 0 0 4 4 4 0 Putative holin Glyco_hydro_3_C PF01915.22 ELR24402.1 - 5e-21 75.6 0.1 6e-21 75.3 0.1 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain DUF543 PF04418.12 ELR24405.1 - 2.2e-07 30.8 0.1 2.8e-07 30.4 0.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF543) LRRCT PF01463.24 ELR24405.1 - 0.0075 16.7 0.1 0.015 15.8 0.1 1.5 1 0 0 1 1 1 1 Leucine rich repeat C-terminal domain TauE PF01925.19 ELR24405.1 - 0.012 15.3 0.0 0.013 15.2 0.0 1.0 1 0 0 1 1 1 0 Sulfite exporter TauE/SafE S1-P1_nuclease PF02265.16 ELR24407.1 - 3.2e-10 40.3 0.1 3.4e-10 40.2 0.1 1.0 1 0 0 1 1 1 1 S1/P1 Nuclease DUF3381 PF11861.8 ELR24408.1 - 0.52 10.1 7.9 0.71 9.6 7.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3381) DUF2236 PF09995.9 ELR24409.1 - 2.4e-17 63.9 0.0 3.5e-17 63.4 0.0 1.2 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2236) Bromodomain PF00439.25 ELR24411.1 - 4.4e-14 52.3 0.0 7.1e-14 51.6 0.0 1.3 1 0 0 1 1 1 1 Bromodomain CNDH2_C PF16858.5 ELR24411.1 - 4.3 7.1 24.5 9.7 6.0 24.5 1.6 1 0 0 1 1 1 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term SPRY PF00622.28 ELR24412.1 - 0.0017 18.5 0.1 0.0038 17.3 0.1 1.7 1 1 0 1 1 1 1 SPRY domain Bacteriocin_IIc PF10439.9 ELR24414.1 - 0.038 14.1 7.3 0.18 11.9 0.4 2.4 1 1 1 2 2 2 0 Bacteriocin class II with double-glycine leader peptide Herpes_glycop PF01528.16 ELR24414.1 - 0.44 9.3 1.3 0.61 8.9 1.3 1.1 1 0 0 1 1 1 0 Herpesvirus glycoprotein M Gly-zipper_Omp PF13488.6 ELR24414.1 - 0.79 9.8 5.9 2.4 8.2 5.9 1.8 1 1 0 1 1 1 0 Glycine zipper Peptidase_C1 PF00112.23 ELR24415.1 - 1.7e-40 139.5 0.0 1.9e-40 139.3 0.0 1.0 1 0 0 1 1 1 1 Papain family cysteine protease Peptidase_C1_2 PF03051.15 ELR24415.1 - 0.082 11.7 0.1 0.12 11.1 0.1 1.1 1 0 0 1 1 1 0 Peptidase C1-like family Palm_thioest PF02089.15 ELR24416.1 - 5.9e-25 88.5 0.0 7.6e-25 88.2 0.0 1.0 1 0 0 1 1 1 1 Palmitoyl protein thioesterase Ank_2 PF12796.7 ELR24417.1 - 4.8e-09 36.7 0.3 7.9e-09 36.0 0.3 1.3 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 ELR24417.1 - 9.2e-09 34.9 0.4 0.0018 18.6 0.0 2.6 2 0 0 2 2 2 2 Ankyrin repeat Ank_5 PF13857.6 ELR24417.1 - 3.4e-07 30.4 1.0 0.015 15.6 0.1 2.6 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 ELR24417.1 - 8.7e-07 29.4 3.4 5.5e-05 23.6 1.0 2.2 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 ELR24417.1 - 5e-06 26.7 1.3 0.0069 16.8 0.1 2.5 2 0 0 2 2 2 2 Ankyrin repeat DUF1217 PF06748.12 ELR24417.1 - 0.047 13.7 0.9 0.54 10.3 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1217) GATA PF00320.27 ELR24418.1 - 5.6e-14 51.4 7.0 9.7e-14 50.7 7.0 1.4 1 0 0 1 1 1 1 GATA zinc finger EP400_N PF15790.5 ELR24418.1 - 0.011 14.7 1.7 0.02 13.8 1.7 1.4 1 0 0 1 1 1 0 E1A-binding protein p400, N-terminal DUF4058 PF13267.6 ELR24418.1 - 0.017 14.5 0.1 0.022 14.2 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4058) ADH_zinc_N_2 PF13602.6 ELR24419.1 - 6.5e-19 69.3 0.1 1e-18 68.7 0.1 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.26 ELR24419.1 - 2.6e-13 50.1 0.2 4.4e-13 49.4 0.2 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Robl_LC7 PF03259.17 ELR24421.1 - 2.7e-10 39.9 0.1 4.2e-10 39.3 0.1 1.3 1 0 0 1 1 1 1 Roadblock/LC7 domain Mcl1_mid PF12341.8 ELR24421.1 - 0.14 11.5 0.0 0.16 11.3 0.0 1.1 1 0 0 1 1 1 0 Minichromosome loss protein, Mcl1, middle region DUF563 PF04577.14 ELR24422.1 - 6.7e-32 111.3 0.0 2.5e-15 57.2 0.0 2.2 1 1 1 2 2 2 2 Protein of unknown function (DUF563) PRCC PF10253.9 ELR24422.1 - 0.016 16.0 1.5 0.03 15.1 1.5 1.4 1 0 0 1 1 1 0 Mitotic checkpoint regulator, MAD2B-interacting SAP PF02037.27 ELR24423.1 - 4.1e-07 29.6 1.5 7.3e-07 28.8 1.5 1.4 1 0 0 1 1 1 1 SAP domain DNA_pol3_delta2 PF13177.6 ELR24424.1 - 7.1e-08 32.4 0.0 1.2e-07 31.7 0.0 1.3 1 0 0 1 1 1 1 DNA polymerase III, delta subunit Rep_fac_C PF08542.11 ELR24424.1 - 0.00083 19.7 0.0 0.0019 18.5 0.0 1.7 1 0 0 1 1 1 1 Replication factor C C-terminal domain DNA_pol3_delta PF06144.13 ELR24424.1 - 0.0044 16.8 0.1 0.0076 16.1 0.1 1.4 1 0 0 1 1 1 1 DNA polymerase III, delta subunit Sigma54_activ_2 PF14532.6 ELR24424.1 - 0.054 13.6 0.0 0.11 12.6 0.0 1.5 1 0 0 1 1 1 0 Sigma-54 interaction domain YCII PF03795.14 ELR24427.1 - 4.6e-15 55.8 0.0 6.5e-15 55.3 0.0 1.2 1 0 0 1 1 1 1 YCII-related domain Amidohydro_2 PF04909.14 ELR24428.1 - 4.6e-37 128.4 0.1 5.2e-37 128.2 0.1 1.1 1 0 0 1 1 1 1 Amidohydrolase DUF3126 PF11324.8 ELR24430.1 - 0.3 10.9 0.1 0.3 10.9 0.1 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF3126) FAM163 PF15069.6 ELR24430.1 - 0.43 11.0 1.7 0.67 10.4 0.1 1.9 2 0 0 2 2 2 0 FAM163 family Uso1_p115_C PF04871.13 ELR24430.1 - 1.6 9.1 12.2 4.4 7.7 12.2 1.7 1 1 0 1 1 1 0 Uso1 / p115 like vesicle tethering protein, C terminal region Rad4 PF03835.15 ELR24431.1 - 1e-12 47.9 1.6 1.2e-12 47.7 1.6 1.1 1 0 0 1 1 1 1 Rad4 transglutaminase-like domain Transglut_core PF01841.19 ELR24431.1 - 0.0071 16.8 3.4 0.0077 16.7 1.9 1.8 2 0 0 2 2 2 1 Transglutaminase-like superfamily Cnd3 PF12719.7 ELR24431.1 - 0.058 12.6 0.2 0.11 11.6 0.0 1.5 2 0 0 2 2 2 0 Nuclear condensing complex subunits, C-term domain YfmQ PF10787.9 ELR24431.1 - 0.15 11.8 0.0 0.26 11.1 0.0 1.3 1 1 0 1 1 1 0 Uncharacterised protein from bacillus cereus group VCBS PF13517.6 ELR24432.1 - 1.7e-08 34.9 3.8 0.0071 16.9 1.4 3.3 2 1 0 2 2 2 2 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.23 ELR24432.1 - 1.2 9.4 21.8 0.046 13.9 0.5 4.3 6 0 0 6 6 6 0 FG-GAP repeat MDH PF02315.16 ELR24433.1 - 0.13 12.3 0.3 0.31 11.1 0.3 1.5 1 0 0 1 1 1 0 Methanol dehydrogenase beta subunit EGF PF00008.27 ELR24433.1 - 3.2 8.2 11.7 0.094 13.0 4.0 2.6 3 0 0 3 3 3 0 EGF-like domain U-box PF04564.15 ELR24434.1 - 4.1e-20 71.7 0.0 1.1e-19 70.3 0.0 1.8 1 0 0 1 1 1 1 U-box domain zf-C3HC4_3 PF13920.6 ELR24434.1 - 2.1e-07 30.7 10.6 3.6e-07 29.9 10.6 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 ELR24434.1 - 0.00033 20.5 10.7 0.00066 19.5 10.7 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 ELR24434.1 - 0.00056 20.2 10.6 0.0011 19.2 10.6 1.5 1 0 0 1 1 1 1 Ring finger domain Prok-RING_4 PF14447.6 ELR24434.1 - 0.01 15.6 10.1 0.024 14.5 10.1 1.6 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-RING_4 PF14570.6 ELR24434.1 - 0.014 15.1 6.7 0.033 14.0 6.7 1.6 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-C3HC4_4 PF15227.6 ELR24434.1 - 0.018 15.2 4.5 0.018 15.2 4.5 2.8 4 0 0 4 4 4 0 zinc finger of C3HC4-type, RING zf-RING_5 PF14634.6 ELR24434.1 - 0.048 13.6 15.4 0.04 13.9 13.2 1.9 1 1 1 2 2 2 0 zinc-RING finger domain zf-C3HC4_2 PF13923.6 ELR24434.1 - 0.62 10.0 11.8 2.4 8.0 11.8 2.1 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 ELR24434.1 - 2.2 8.4 10.4 0.67 10.0 6.7 2.1 2 0 0 2 2 2 0 RING-type zinc-finger RasGEF PF00617.19 ELR24437.1 - 4.1e-15 56.4 0.0 7.5e-15 55.6 0.0 1.4 1 0 0 1 1 1 1 RasGEF domain Endonuc-PvuII PF09225.10 ELR24437.1 - 0.12 12.2 0.0 0.19 11.5 0.0 1.3 1 0 0 1 1 1 0 Restriction endonuclease PvuII tRNA-synt_His PF13393.6 ELR24438.1 - 8.1e-28 97.6 0.2 6.1e-16 58.6 0.1 2.3 1 1 1 2 2 2 2 Histidyl-tRNA synthetase tRNA-synt_2b PF00587.25 ELR24438.1 - 4.1e-14 52.9 0.0 5.8e-14 52.5 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.20 ELR24438.1 - 1.2e-09 38.2 0.0 2.7e-09 37.1 0.0 1.6 1 0 0 1 1 1 1 Anticodon binding domain tRNA-synt_2d PF01409.20 ELR24438.1 - 1.4e-05 24.7 0.4 7.9e-05 22.2 0.0 2.0 2 0 0 2 2 2 1 tRNA synthetases class II core domain (F) F_actin_cap_B PF01115.17 ELR24441.1 - 8.1e-104 346.4 0.0 9.3e-104 346.2 0.0 1.0 1 0 0 1 1 1 1 F-actin capping protein, beta subunit HPS3_Mid PF14762.6 ELR24442.1 - 9.4e-36 123.4 0.0 4.8e-34 117.8 0.0 3.0 2 1 0 2 2 2 1 Hermansky-Pudlak syndrome 3, middle region HPS3_N PF14761.6 ELR24442.1 - 9.7e-09 35.1 0.0 0.0061 16.1 0.0 3.3 1 1 2 3 3 3 3 Hermansky-Pudlak syndrome 3 HPS3_C PF14763.6 ELR24442.1 - 3.1e-07 30.1 1.0 5.2e-07 29.3 1.0 1.2 1 0 0 1 1 1 1 Hermansky-Pudlak syndrome 3, C-terminal TPR_7 PF13176.6 ELR24442.1 - 0.012 15.6 0.4 0.41 10.8 0.1 3.3 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_2 PF07719.17 ELR24442.1 - 0.18 12.0 1.8 6.8 7.1 0.2 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat ANAPC3 PF12895.7 ELR24442.1 - 0.19 12.0 1.1 1 9.6 0.3 2.7 3 0 0 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 Ank_2 PF12796.7 ELR24443.1 - 4.3e-13 49.7 1.8 1.4e-08 35.2 0.1 2.9 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ELR24443.1 - 4.8e-12 46.1 0.1 2e-05 25.0 0.0 2.9 1 1 2 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 ELR24443.1 - 1.1e-11 43.9 0.3 0.00016 21.8 0.0 4.0 3 1 1 4 4 4 2 Ankyrin repeat Ank_5 PF13857.6 ELR24443.1 - 1.2e-10 41.4 0.3 7.4e-09 35.7 0.2 2.7 1 1 2 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.30 ELR24443.1 - 2.4e-10 40.4 3.9 1.1e-05 25.6 0.1 3.6 3 1 0 3 3 3 2 Ankyrin repeat DUF249 PF03158.13 ELR24443.1 - 0.15 11.8 0.3 0.41 10.3 0.1 1.7 2 0 0 2 2 2 0 Multigene family 530 protein Pro-kuma_activ PF09286.11 ELR24444.1 - 0.36 11.1 4.6 0.19 12.0 2.0 1.8 2 0 0 2 2 2 0 Pro-kumamolisin, activation domain WDCP PF15390.6 ELR24444.1 - 1.6 7.0 22.2 2.1 6.6 22.2 1.2 1 0 0 1 1 1 0 WD repeat and coiled-coil-containing protein family Presenilin PF01080.17 ELR24446.1 - 8.3e-99 331.0 38.1 3.9e-47 160.9 3.9 3.1 1 1 2 3 3 3 3 Presenilin G-patch PF01585.23 ELR24448.1 - 6.1e-12 45.2 6.5 1.3e-11 44.2 6.5 1.5 1 0 0 1 1 1 1 G-patch domain RRM_1 PF00076.22 ELR24448.1 - 2.2e-05 24.2 0.0 4.7e-05 23.1 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) G-patch_2 PF12656.7 ELR24448.1 - 0.0088 16.1 2.2 0.024 14.7 2.2 1.7 1 0 0 1 1 1 1 G-patch domain Phage_min_cap2 PF06152.11 ELR24448.1 - 0.067 12.1 2.9 0.092 11.6 2.9 1.2 1 0 0 1 1 1 0 Phage minor capsid protein 2 UCMA PF17085.5 ELR24448.1 - 0.95 9.5 6.9 1.6 8.7 6.9 1.3 1 0 0 1 1 1 0 Unique cartilage matrix associated protein Pkinase_Tyr PF07714.17 ELR24449.1 - 3.7e-122 406.6 0.0 6.1e-60 202.7 0.0 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 ELR24449.1 - 5.9e-106 353.6 0.0 3.8e-55 187.1 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Guanylate_cyc PF00211.20 ELR24449.1 - 2e-15 56.9 0.0 1e-14 54.6 0.0 2.1 2 0 0 2 2 2 1 Adenylate and Guanylate cyclase catalytic domain APH PF01636.23 ELR24449.1 - 7.7e-07 29.3 0.1 0.00058 19.9 0.0 2.8 2 0 0 2 2 2 2 Phosphotransferase enzyme family FTA2 PF13095.6 ELR24449.1 - 7e-05 22.5 0.0 0.2 11.3 0.0 2.9 2 1 1 3 3 3 2 Kinetochore Sim4 complex subunit FTA2 Kinase-like PF14531.6 ELR24449.1 - 0.00031 20.1 0.1 0.81 8.9 0.0 2.3 2 0 0 2 2 2 2 Kinase-like EGF_2 PF07974.13 ELR24449.1 - 0.0018 18.6 10.8 0.0033 17.8 10.8 1.5 1 0 0 1 1 1 1 EGF-like domain Pkinase_fungal PF17667.1 ELR24449.1 - 0.0043 15.9 2.1 1 8.1 0.1 3.0 3 0 0 3 3 3 2 Fungal protein kinase RIO1 PF01163.22 ELR24449.1 - 0.027 14.1 0.9 3.8 7.1 0.1 3.0 2 1 1 3 3 3 0 RIO1 family Haspin_kinase PF12330.8 ELR24449.1 - 0.035 13.0 0.0 0.035 13.0 0.0 2.8 3 0 0 3 3 2 0 Haspin like kinase domain Kdo PF06293.14 ELR24449.1 - 0.065 12.6 0.0 6.2 6.1 0.0 2.4 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family EB PF01683.18 ELR24449.1 - 0.8 10.0 7.0 1.7 9.0 7.0 1.5 1 0 0 1 1 1 0 EB module EGF_Tenascin PF18720.1 ELR24449.1 - 0.96 9.6 6.9 1.3 9.1 6.0 1.8 1 1 0 1 1 1 0 Tenascin EGF domain I-EGF_1 PF18372.1 ELR24449.1 - 2.1 8.5 6.5 6.1 7.0 6.5 1.8 1 0 0 1 1 1 0 Integrin beta epidermal growth factor like domain 1 R3H PF01424.22 ELR24450.1 - 0.001 19.0 1.0 0.0014 18.6 0.0 1.8 2 0 0 2 2 2 1 R3H domain F-box-like PF12937.7 ELR24450.1 - 0.035 14.0 0.3 0.035 14.0 0.3 2.0 2 0 0 2 2 2 0 F-box-like F-box PF00646.33 ELR24450.1 - 0.088 12.7 0.1 0.088 12.7 0.1 1.8 2 0 0 2 2 2 0 F-box domain Pkinase_Tyr PF07714.17 ELR24451.1 - 6.8e-07 28.8 0.0 1.1e-06 28.2 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ELR24451.1 - 1.8e-05 24.2 0.0 2.4e-05 23.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain CYTH PF01928.21 ELR24451.1 - 0.052 13.5 0.0 0.064 13.2 0.0 1.1 1 0 0 1 1 1 0 CYTH domain Pkinase_Tyr PF07714.17 ELR24453.1 - 2.4e-119 397.4 0.0 9.1e-59 198.8 0.0 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 ELR24453.1 - 7.8e-102 340.1 0.0 4.2e-53 180.4 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain PBP_like_2 PF12849.7 ELR24453.1 - 1.2e-18 67.8 15.4 3.7e-15 56.4 5.5 2.3 2 0 0 2 2 2 2 PBP superfamily domain Guanylate_cyc PF00211.20 ELR24453.1 - 1.5e-07 31.3 0.1 4.7e-07 29.6 0.0 1.8 2 0 0 2 2 2 1 Adenylate and Guanylate cyclase catalytic domain APH PF01636.23 ELR24453.1 - 8.9e-06 25.8 3.9 0.00045 20.2 0.0 2.7 3 0 0 3 3 2 2 Phosphotransferase enzyme family EGF_2 PF07974.13 ELR24453.1 - 3.5e-05 24.1 12.6 6.5e-05 23.2 12.6 1.5 1 0 0 1 1 1 1 EGF-like domain FTA2 PF13095.6 ELR24453.1 - 3.7e-05 23.5 0.0 0.07 12.7 0.0 2.9 2 1 1 3 3 3 2 Kinetochore Sim4 complex subunit FTA2 Kinase-like PF14531.6 ELR24453.1 - 0.0002 20.8 0.0 0.54 9.5 0.0 2.3 2 0 0 2 2 2 2 Kinase-like Haspin_kinase PF12330.8 ELR24453.1 - 0.00022 20.3 0.0 0.034 13.1 0.0 2.5 2 0 0 2 2 2 1 Haspin like kinase domain Pkinase_fungal PF17667.1 ELR24453.1 - 0.013 14.3 0.0 1.9 7.2 0.0 2.2 2 0 0 2 2 2 0 Fungal protein kinase hEGF PF12661.7 ELR24453.1 - 0.038 14.6 6.6 0.1 13.3 6.6 1.8 1 0 0 1 1 1 0 Human growth factor-like EGF RIO1 PF01163.22 ELR24453.1 - 0.068 12.8 0.6 3 7.4 0.1 2.6 2 1 1 3 3 3 0 RIO1 family Kdo PF06293.14 ELR24453.1 - 0.077 12.3 0.1 3 7.1 0.0 2.4 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family EGF_Tenascin PF18720.1 ELR24453.1 - 0.55 10.3 11.3 0.18 11.9 6.3 2.3 2 0 0 2 2 2 0 Tenascin EGF domain EB PF01683.18 ELR24453.1 - 0.76 10.1 5.7 1.6 9.1 5.7 1.4 1 0 0 1 1 1 0 EB module I-EGF_1 PF18372.1 ELR24453.1 - 1.1 9.5 9.1 0.069 13.3 3.8 1.8 2 0 0 2 2 1 0 Integrin beta epidermal growth factor like domain 1 EGF PF00008.27 ELR24453.1 - 1.5 9.2 8.1 2.9 8.3 8.1 1.5 1 0 0 1 1 1 0 EGF-like domain Laminin_EGF PF00053.24 ELR24453.1 - 3 8.0 8.8 6.3 7.0 8.8 1.4 1 0 0 1 1 1 0 Laminin EGF domain SapB_1 PF05184.15 ELR24454.1 - 5.9e-11 42.2 0.3 5.9e-11 42.2 0.3 2.0 3 0 0 3 3 3 1 Saposin-like type B, region 1 SapB_2 PF03489.17 ELR24454.1 - 6.6e-11 42.1 0.2 1.2e-10 41.3 0.2 1.5 1 0 0 1 1 1 1 Saposin-like type B, region 2 DIM PF08194.12 ELR24454.1 - 0.024 14.9 1.0 0.06 13.5 1.0 1.8 1 0 0 1 1 1 0 DIM protein URO-D PF01208.17 ELR24455.1 - 7.8e-117 390.3 0.1 2.7e-99 332.6 0.0 2.0 1 1 1 2 2 2 2 Uroporphyrinogen decarboxylase (URO-D) Ints3 PF10189.9 ELR24456.1 - 9.5e-93 309.6 0.1 1.7e-92 308.8 0.1 1.4 1 0 0 1 1 1 1 Integrator complex subunit 3 LIM PF00412.22 ELR24457.1 - 1.8e-18 66.5 17.7 9.8e-13 48.1 1.4 2.3 2 0 0 2 2 2 2 LIM domain DUF3127 PF11325.8 ELR24457.1 - 0.041 14.1 0.0 0.059 13.6 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3127) C1_4 PF07975.12 ELR24457.1 - 0.41 10.9 11.8 1.2 9.4 1.1 2.5 2 0 0 2 2 2 0 TFIIH C1-like domain DENN PF02141.21 ELR24458.1 - 7.7e-42 143.3 0.0 1.3e-41 142.6 0.0 1.4 1 0 0 1 1 1 1 DENN (AEX-3) domain dDENN PF03455.19 ELR24458.1 - 3.5e-05 23.7 0.4 9.4e-05 22.3 0.4 1.7 1 0 0 1 1 1 1 dDENN domain uDENN PF03456.18 ELR24458.1 - 0.025 15.3 2.0 0.028 15.2 0.3 2.1 2 1 0 2 2 2 0 uDENN domain SPA PF08616.10 ELR24458.1 - 0.15 12.0 0.1 0.3 11.1 0.1 1.5 1 0 0 1 1 1 0 Stabilization of polarity axis EF-hand_5 PF13202.6 ELR24459.1 - 1.9e-05 23.9 0.2 5.6e-05 22.5 0.2 1.8 1 0 0 1 1 1 1 EF hand EF-hand_1 PF00036.32 ELR24459.1 - 0.0001 21.6 0.8 0.00021 20.6 0.1 1.9 2 0 0 2 2 2 1 EF hand DUF1826 PF08856.11 ELR24459.1 - 0.00028 20.9 0.0 0.0004 20.4 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1826) EF-hand_7 PF13499.6 ELR24459.1 - 0.0016 18.9 0.7 0.0036 17.7 0.7 2.0 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 ELR24459.1 - 0.005 16.7 0.3 0.018 14.9 0.2 1.9 1 1 0 1 1 1 1 EF-hand domain EF-hand_8 PF13833.6 ELR24459.1 - 0.0096 15.8 1.6 0.029 14.2 0.1 2.5 4 0 0 4 4 4 1 EF-hand domain pair Cas_Cas7 PF05107.12 ELR24459.1 - 0.031 13.8 0.1 0.042 13.4 0.1 1.2 1 0 0 1 1 1 0 CRISPR-associated protein Cas7 HMMR_N PF15905.5 ELR24461.1 - 0.001 18.6 40.5 0.033 13.7 17.4 3.0 1 1 1 2 2 2 2 Hyaluronan mediated motility receptor N-terminal DUF2529 PF10740.9 ELR24461.1 - 0.43 10.2 3.9 0.74 9.4 3.4 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF2529) Fez1 PF06818.15 ELR24461.1 - 0.8 10.1 43.1 3.3 8.1 18.0 2.6 2 1 0 2 2 2 0 Fez1 Med9 PF07544.13 ELR24461.1 - 7.7 6.7 34.1 1.1 9.4 3.4 4.5 2 1 1 4 4 4 0 RNA polymerase II transcription mediator complex subunit 9 2_5_RNA_ligase2 PF13563.6 ELR24462.1 - 2.5e-19 69.7 2.1 7.8e-19 68.1 2.1 1.7 1 1 0 1 1 1 1 2'-5' RNA ligase superfamily LigT_PEase PF02834.16 ELR24462.1 - 3.8e-07 30.2 1.8 0.0065 16.6 0.1 2.2 1 1 1 2 2 2 2 LigT like Phosphoesterase DIL PF01843.19 ELR24463.1 - 1.4e-20 73.5 1.0 4.1e-20 72.0 0.0 2.3 2 0 0 2 2 2 1 DIL domain NT-C2 PF10358.9 ELR24463.1 - 1.5e-09 37.7 0.3 7.7e-09 35.4 0.0 2.1 2 0 0 2 2 2 1 N-terminal C2 in EEIG1 and EHBP1 proteins Fez1 PF06818.15 ELR24463.1 - 1.1 9.7 50.7 1.9 8.9 8.1 3.2 2 1 1 3 3 3 0 Fez1 zf-C2HC5 PF06221.13 ELR24466.1 - 6.1e-12 45.4 6.4 1e-11 44.7 6.4 1.3 1 0 0 1 1 1 1 Putative zinc finger motif, C2HC5-type PP1_inhibitor PF05361.12 ELR24466.1 - 0.0013 18.7 0.4 0.0021 18.1 0.4 1.3 1 0 0 1 1 1 1 PKC-activated protein phosphatase-1 inhibitor PWI PF01480.17 ELR24466.1 - 0.0062 16.8 0.3 0.86 10.0 0.0 2.2 1 1 1 2 2 2 2 PWI domain DUF1772 PF08592.11 ELR24467.1 - 0.00034 20.9 0.3 0.00056 20.2 0.3 1.5 1 1 0 1 1 1 1 Domain of unknown function (DUF1772) YfhO PF09586.10 ELR24467.1 - 0.0013 17.1 0.5 0.0016 16.8 0.5 1.0 1 0 0 1 1 1 1 Bacterial membrane protein YfhO DUF2339 PF10101.9 ELR24467.1 - 0.0016 17.1 3.2 0.002 16.8 3.2 1.0 1 0 0 1 1 1 1 Predicted membrane protein (DUF2339) Acyl_transf_3 PF01757.22 ELR24467.1 - 0.015 14.4 2.2 0.019 14.1 2.2 1.0 1 0 0 1 1 1 0 Acyltransferase family Peptidase_U4 PF03419.13 ELR24467.1 - 0.019 14.2 3.0 0.024 13.9 3.0 1.1 1 0 0 1 1 1 0 Sporulation factor SpoIIGA DUF2723 PF11028.8 ELR24467.1 - 0.054 13.4 4.6 0.072 13.0 4.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2723) TIC20 PF16166.5 ELR24467.1 - 0.067 13.0 2.4 0.087 12.6 2.1 1.4 1 1 0 1 1 1 0 Chloroplast import apparatus Tic20-like DUF2157 PF09925.9 ELR24467.1 - 0.13 12.0 3.6 0.21 11.4 3.6 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2157) SLATT_3 PF18184.1 ELR24467.1 - 0.14 12.2 1.7 0.15 12.2 0.6 1.6 2 0 0 2 2 2 0 SMODS and SLOG-associating 2TM effector domain 3 DUF3278 PF11683.8 ELR24467.1 - 0.16 12.1 3.1 0.14 12.3 2.0 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3278) DUF2070 PF09843.9 ELR24467.1 - 0.39 8.9 7.6 0.53 8.5 7.6 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) DUF4131 PF13567.6 ELR24467.1 - 0.44 10.2 4.2 0.15 11.7 1.4 1.7 1 1 1 2 2 2 0 Domain of unknown function (DUF4131) PMT_2 PF13231.6 ELR24467.1 - 0.57 10.4 10.4 1.2 9.4 10.4 1.4 1 1 0 1 1 1 0 Dolichyl-phosphate-mannose-protein mannosyltransferase DUF3021 PF11457.8 ELR24467.1 - 0.68 10.3 5.5 1 9.7 5.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3021) DUF4149 PF13664.6 ELR24467.1 - 1.6 9.1 5.9 0.61 10.4 1.5 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4149) Wzy_C PF04932.15 ELR24467.1 - 7.4 6.2 6.6 1.3 8.6 1.1 2.0 1 1 1 2 2 2 0 O-Antigen ligase DUF2076 PF09849.9 ELR24468.1 - 6.7e-12 46.0 8.6 8e-12 45.8 8.6 1.1 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2076) CHCH PF06747.13 ELR24468.1 - 5.8e-05 23.1 3.4 8.5e-05 22.6 3.4 1.3 1 0 0 1 1 1 1 CHCH domain COX6B PF02297.17 ELR24468.1 - 0.021 15.1 3.4 0.051 13.8 3.4 1.6 1 1 1 2 2 2 0 Cytochrome oxidase c subunit VIb Ras PF00071.22 ELR24469.1 - 3.4e-50 169.8 1.4 3.9e-47 159.9 1.4 2.0 1 1 0 1 1 1 1 Ras family Roc PF08477.13 ELR24469.1 - 6.5e-29 100.6 0.3 3.2e-28 98.4 0.3 2.0 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR24469.1 - 9.4e-12 44.7 0.3 2.1e-09 37.1 0.3 2.1 1 1 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 ELR24469.1 - 1.2e-07 31.8 0.1 4.1e-07 30.1 0.0 1.8 1 1 0 2 2 2 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 ELR24469.1 - 1.7e-05 24.5 0.6 0.0084 15.7 0.6 3.2 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 ELR24469.1 - 4.9e-05 22.8 0.2 6.5e-05 22.4 0.2 1.4 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 ELR24469.1 - 9.7e-05 22.3 0.0 0.0029 17.5 0.0 2.1 2 0 0 2 2 2 1 RsgA GTPase PduV-EutP PF10662.9 ELR24469.1 - 0.001 18.8 0.2 0.077 12.7 0.1 2.2 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation Septin PF00735.18 ELR24469.1 - 0.0062 15.9 0.5 0.012 14.9 0.1 1.6 2 0 0 2 2 2 1 Septin SRPRB PF09439.10 ELR24469.1 - 0.0071 15.8 0.0 0.012 15.0 0.0 1.4 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit AAA_22 PF13401.6 ELR24469.1 - 0.0074 16.6 0.0 0.01 16.1 0.0 1.4 1 1 0 1 1 1 1 AAA domain AAA_24 PF13479.6 ELR24469.1 - 0.01 15.5 0.0 0.019 14.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 ELR24469.1 - 0.013 15.9 0.1 0.071 13.5 0.0 2.0 2 0 0 2 2 2 0 AAA ATPase domain cobW PF02492.19 ELR24469.1 - 0.013 15.1 0.2 0.065 12.8 0.1 2.0 1 1 1 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_7 PF12775.7 ELR24469.1 - 0.017 14.6 0.1 0.026 14.0 0.1 1.2 1 0 0 1 1 1 0 P-loop containing dynein motor region NTPase_1 PF03266.15 ELR24469.1 - 0.036 14.0 0.0 0.064 13.2 0.0 1.4 1 0 0 1 1 1 0 NTPase G-alpha PF00503.20 ELR24469.1 - 0.041 13.0 1.1 0.17 11.0 0.2 2.1 1 1 2 3 3 3 0 G-protein alpha subunit ATPase_2 PF01637.18 ELR24469.1 - 0.042 13.7 0.3 0.079 12.9 0.1 1.5 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea TniB PF05621.11 ELR24469.1 - 0.075 12.4 0.0 0.11 11.9 0.0 1.3 1 0 0 1 1 1 0 Bacterial TniB protein RNA_helicase PF00910.22 ELR24469.1 - 0.09 13.2 0.0 0.26 11.7 0.0 1.8 2 0 0 2 2 2 0 RNA helicase NB-ARC PF00931.22 ELR24469.1 - 0.097 11.8 0.3 0.14 11.3 0.1 1.4 2 0 0 2 2 2 0 NB-ARC domain NACHT PF05729.12 ELR24469.1 - 0.098 12.6 0.0 0.16 11.9 0.0 1.3 1 0 0 1 1 1 0 NACHT domain AAA_5 PF07728.14 ELR24469.1 - 0.14 12.1 0.0 0.31 11.0 0.0 1.6 1 1 1 2 2 2 0 AAA domain (dynein-related subfamily) ATP_bind_1 PF03029.17 ELR24469.1 - 0.15 11.8 1.1 37 4.0 0.0 2.9 2 1 1 3 3 3 0 Conserved hypothetical ATP binding protein HIT PF01230.23 ELR24470.1 - 9.3e-22 77.6 0.1 1.2e-21 77.3 0.1 1.1 1 0 0 1 1 1 1 HIT domain DcpS_C PF11969.8 ELR24470.1 - 6.3e-06 26.6 0.0 9.6e-06 26.1 0.0 1.3 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding CwfJ_C_1 PF04677.15 ELR24470.1 - 0.099 12.5 0.2 0.18 11.6 0.2 1.5 1 1 0 1 1 1 0 Protein similar to CwfJ C-terminus 1 Metallophos PF00149.28 ELR24471.1 - 3.7e-17 63.5 6.3 7.3e-17 62.5 6.3 1.5 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_C PF14008.6 ELR24471.1 - 1.4e-10 41.8 0.0 4.9e-10 40.1 0.0 1.9 1 0 0 1 1 1 1 Iron/zinc purple acid phosphatase-like protein C Metallophos_2 PF12850.7 ELR24471.1 - 3.3e-07 30.7 0.0 8.3e-07 29.3 0.0 1.6 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Pur_ac_phosph_N PF16656.5 ELR24471.1 - 0.0007 20.1 0.3 0.0019 18.7 0.3 1.8 1 0 0 1 1 1 1 Purple acid Phosphatase, N-terminal domain PhoD PF09423.10 ELR24471.1 - 0.013 14.6 0.3 0.095 11.7 0.0 2.4 3 0 0 3 3 3 0 PhoD-like phosphatase IMPDH PF00478.25 ELR24472.1 - 0.07 12.1 0.0 0.072 12.1 0.0 1.0 1 0 0 1 1 1 0 IMP dehydrogenase / GMP reductase domain Polysacc_lyase PF14099.6 ELR24474.1 - 5.7e-12 45.9 1.0 8e-12 45.5 0.6 1.4 1 1 0 1 1 1 1 Polysaccharide lyase SKG6 PF08693.10 ELR24475.1 - 0.003 16.9 10.3 0.003 16.9 10.3 2.5 2 0 0 2 2 2 1 Transmembrane alpha-helix domain Rax2 PF12768.7 ELR24475.1 - 0.023 14.2 0.1 0.061 12.8 0.0 1.8 2 0 0 2 2 2 0 Cortical protein marker for cell polarity DIE2_ALG10 PF04922.12 ELR24476.1 - 2.1e-97 326.9 29.4 3e-97 326.4 29.4 1.2 1 0 0 1 1 1 1 DIE2/ALG10 family GGACT PF06094.12 ELR24477.1 - 1.9e-17 64.0 2.9 2.6e-16 60.3 2.9 2.0 1 1 0 1 1 1 1 Gamma-glutamyl cyclotransferase, AIG2-like ChaC PF04752.12 ELR24477.1 - 0.02 15.0 0.1 0.027 14.5 0.1 1.3 1 0 0 1 1 1 0 ChaC-like protein Ank_2 PF12796.7 ELR24478.1 - 8.1e-33 112.9 0.1 1.1e-08 35.5 0.0 5.4 3 2 2 5 5 5 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ELR24478.1 - 1.2e-27 95.9 3.8 7.4e-06 26.4 0.0 7.8 4 2 3 7 7 7 6 Ankyrin repeats (many copies) Ank PF00023.30 ELR24478.1 - 1.7e-27 94.6 7.5 0.00015 22.0 0.2 7.4 7 0 0 7 7 7 5 Ankyrin repeat Ank_3 PF13606.6 ELR24478.1 - 1.7e-23 80.1 2.9 0.004 17.5 0.0 7.2 6 0 0 6 6 6 5 Ankyrin repeat Ank_5 PF13857.6 ELR24478.1 - 1.3e-21 76.4 8.2 2e-05 24.8 0.0 8.1 5 1 3 8 8 8 4 Ankyrin repeats (many copies) SUFU PF05076.13 ELR24478.1 - 1.2e-05 25.4 0.0 2.9e-05 24.1 0.0 1.7 1 0 0 1 1 1 1 Suppressor of fused protein (SUFU) Pkinase_Tyr PF07714.17 ELR24479.1 - 1.5e-65 221.0 0.0 2.6e-65 220.3 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ELR24479.1 - 7.8e-41 140.2 0.0 1.8e-40 139.0 0.0 1.5 2 0 0 2 2 2 1 Protein kinase domain DEP PF00610.21 ELR24479.1 - 3.7e-18 65.3 0.6 9.2e-18 64.1 0.6 1.7 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) Kinase-like PF14531.6 ELR24479.1 - 0.029 13.7 0.0 0.053 12.8 0.0 1.3 1 0 0 1 1 1 0 Kinase-like BTB PF00651.31 ELR24480.1 - 1.5e-17 63.8 0.0 1.3e-16 60.8 0.0 2.2 1 1 1 2 2 2 1 BTB/POZ domain BACK PF07707.15 ELR24480.1 - 4.8e-11 42.7 0.0 3.1e-10 40.1 0.0 2.0 2 0 0 2 2 2 1 BTB And C-terminal Kelch PH PF00169.29 ELR24481.1 - 4.3e-15 56.1 0.0 1.1e-14 54.8 0.0 1.7 2 0 0 2 2 2 1 PH domain PH_11 PF15413.6 ELR24481.1 - 0.0015 18.9 0.0 0.058 13.8 0.0 2.5 2 0 0 2 2 2 1 Pleckstrin homology domain Longin PF13774.6 ELR24481.1 - 0.035 14.1 0.0 0.06 13.4 0.0 1.4 1 0 0 1 1 1 0 Regulated-SNARE-like domain PH_3 PF14593.6 ELR24481.1 - 0.13 12.4 0.1 0.79 9.9 0.1 2.1 1 1 0 1 1 1 0 PH domain TFIIA PF03153.13 ELR24482.1 - 0.00092 19.3 1.2 0.00099 19.2 1.2 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit NOA36 PF06524.12 ELR24482.1 - 0.021 14.2 9.9 0.028 13.7 9.9 1.2 1 0 0 1 1 1 0 NOA36 protein CDC45 PF02724.14 ELR24482.1 - 0.024 13.0 0.8 0.028 12.7 0.8 1.3 1 0 0 1 1 1 0 CDC45-like protein RXT2_N PF08595.11 ELR24482.1 - 0.025 14.6 1.3 0.044 13.8 1.3 1.5 1 0 0 1 1 1 0 RXT2-like, N-terminal Sigma70_ner PF04546.13 ELR24482.1 - 0.08 12.8 3.0 0.12 12.2 3.0 1.4 1 0 0 1 1 1 0 Sigma-70, non-essential region SGT1 PF07093.11 ELR24482.1 - 0.084 11.3 0.9 0.11 10.9 0.9 1.3 1 0 0 1 1 1 0 SGT1 protein DNA_pol_phi PF04931.13 ELR24482.1 - 0.69 7.9 13.0 18 3.3 13.6 2.0 2 0 0 2 2 2 0 DNA polymerase phi CENP-B_dimeris PF09026.10 ELR24482.1 - 0.7 10.3 17.8 1.6 9.2 17.8 1.6 1 0 0 1 1 1 0 Centromere protein B dimerisation domain DUF2457 PF10446.9 ELR24482.1 - 0.8 8.8 13.9 1.3 8.1 13.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Nop14 PF04147.12 ELR24482.1 - 1.2 7.2 7.0 1.7 6.7 7.0 1.2 1 0 0 1 1 1 0 Nop14-like family FAM176 PF14851.6 ELR24482.1 - 2.3 7.9 6.5 0.59 9.8 3.4 1.6 2 0 0 2 2 2 0 FAM176 family Cwf_Cwc_15 PF04889.12 ELR24482.1 - 3.1 7.5 12.1 2.9 7.6 11.0 1.5 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein PBP1_TM PF14812.6 ELR24482.1 - 4.2 7.8 13.0 0.71 10.3 9.4 1.5 2 0 0 2 2 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal RRN3 PF05327.11 ELR24482.1 - 8.9 4.7 6.7 13 4.2 6.7 1.2 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Aa_trans PF01490.18 ELR24483.1 - 3.7e-69 233.4 19.5 4.8e-69 233.0 19.5 1.1 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.13 ELR24483.1 - 2.9e-07 29.9 7.4 2.9e-07 29.9 7.4 1.8 2 0 0 2 2 2 1 Tryptophan/tyrosine permease family Cu-oxidase_2 PF07731.14 ELR24484.1 - 5.6e-22 77.9 0.2 1.2e-21 76.9 0.2 1.6 1 0 0 1 1 1 1 Multicopper oxidase Cu-oxidase_3 PF07732.15 ELR24484.1 - 1.9e-11 44.0 0.1 3e-06 27.2 0.1 3.3 3 0 0 3 3 3 2 Multicopper oxidase Cu-oxidase PF00394.22 ELR24484.1 - 0.00096 19.3 0.0 0.002 18.2 0.0 1.5 1 0 0 1 1 1 1 Multicopper oxidase eIF-5a PF01287.20 ELR24485.1 - 1.5e-05 25.0 0.2 1.9e-05 24.7 0.2 1.1 1 0 0 1 1 1 1 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold PQQ_2 PF13360.6 ELR24485.1 - 0.059 12.9 0.1 0.059 12.9 0.1 1.1 1 0 0 1 1 1 0 PQQ-like domain PQQ PF01011.21 ELR24485.1 - 0.11 12.4 0.0 0.15 12.0 0.0 1.3 1 0 0 1 1 1 0 PQQ enzyme repeat IncD PF17628.2 ELR24486.1 - 0.33 10.7 2.3 0.62 9.8 2.3 1.5 1 0 0 1 1 1 0 Inclusion membrane protein D MARVEL PF01284.23 ELR24487.1 - 0.0026 17.8 15.2 0.0075 16.3 14.8 2.0 1 1 1 2 2 2 1 Membrane-associating domain DUF805 PF05656.14 ELR24487.1 - 0.025 15.0 6.4 0.049 14.0 6.4 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF805) DUF5527 PF17665.1 ELR24487.1 - 0.15 11.6 1.1 0.31 10.6 1.1 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF5527) DUF5518 PF17647.1 ELR24487.1 - 0.16 12.1 30.5 0.46 10.6 22.8 2.9 2 1 0 2 2 2 0 Family of unknown function (DUF5518) ABC_export PF16962.5 ELR24487.1 - 0.37 9.2 11.3 0.9 7.9 11.4 1.6 1 1 0 1 1 1 0 Putative ABC exporter Frag1 PF10277.9 ELR24487.1 - 1.2 8.6 9.6 0.026 14.1 3.1 1.5 2 0 0 2 2 2 0 Frag1/DRAM/Sfk1 family Gemini_mov PF01708.16 ELR24487.1 - 2.5 7.9 6.2 8.7 6.2 0.2 2.5 2 0 0 2 2 2 0 Geminivirus putative movement protein Ac76 PF05814.11 ELR24487.1 - 3.2 7.8 9.2 3.7 7.6 5.3 2.3 2 0 0 2 2 2 0 Orf76 (Ac76) Bac_rhodopsin PF01036.18 ELR24487.1 - 6.6 6.2 13.7 0.49 9.9 7.8 2.0 2 1 0 2 2 2 0 Bacteriorhodopsin-like protein FAD_binding_3 PF01494.19 ELR24488.1 - 2e-86 290.4 0.4 2.6e-86 290.0 0.4 1.1 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.24 ELR24488.1 - 2.5e-09 37.2 1.5 1.5e-05 24.8 0.2 2.3 2 0 0 2 2 2 2 FAD dependent oxidoreductase Pyr_redox PF00070.27 ELR24488.1 - 8.2e-08 32.7 0.4 1.5e-05 25.4 0.1 2.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 ELR24488.1 - 1.3e-07 31.1 0.2 0.00015 21.1 0.1 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 ELR24488.1 - 2.9e-07 29.5 0.3 0.00023 20.0 0.0 2.1 2 0 0 2 2 2 2 HI0933-like protein NAD_binding_8 PF13450.6 ELR24488.1 - 2.9e-05 24.2 0.2 8.2e-05 22.8 0.2 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.6 ELR24488.1 - 0.00012 21.4 0.0 0.00066 19.0 0.0 1.9 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 ELR24488.1 - 0.00019 20.9 0.5 0.00025 20.5 0.5 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 ELR24488.1 - 0.00024 20.3 1.1 0.00035 19.8 0.1 1.7 2 0 0 2 2 2 1 FAD binding domain Trp_halogenase PF04820.14 ELR24488.1 - 0.0012 17.8 0.1 0.048 12.5 0.1 2.1 2 0 0 2 2 2 1 Tryptophan halogenase ApbA PF02558.16 ELR24488.1 - 0.0012 18.5 0.1 0.0023 17.6 0.1 1.4 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA Lycopene_cycl PF05834.12 ELR24488.1 - 0.0016 17.6 2.0 0.0088 15.1 2.0 1.9 1 1 0 1 1 1 1 Lycopene cyclase protein TrkA_N PF02254.18 ELR24488.1 - 0.0061 16.8 0.1 0.67 10.2 0.1 2.4 2 0 0 2 2 2 1 TrkA-N domain Thi4 PF01946.17 ELR24488.1 - 0.013 14.7 0.2 0.034 13.4 0.0 1.7 2 0 0 2 2 2 0 Thi4 family SE PF08491.10 ELR24488.1 - 0.027 13.5 0.0 0.039 13.0 0.0 1.2 1 0 0 1 1 1 0 Squalene epoxidase AlaDh_PNT_C PF01262.21 ELR24488.1 - 0.037 13.3 0.1 0.06 12.6 0.1 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain NAD_binding_7 PF13241.6 ELR24488.1 - 0.051 14.0 0.1 0.12 12.8 0.0 1.7 1 1 0 1 1 1 0 Putative NAD(P)-binding Amino_oxidase PF01593.24 ELR24488.1 - 0.068 12.4 0.7 6.2 6.0 0.0 2.4 2 0 0 2 2 2 0 Flavin containing amine oxidoreductase Glu_dehyd_C PF16912.5 ELR24488.1 - 0.12 11.8 0.1 0.2 11.1 0.1 1.3 1 0 0 1 1 1 0 Glucose dehydrogenase C-terminus Methyltr_RsmB-F PF01189.17 ELR24489.1 - 7.6e-31 107.3 0.0 3.3e-17 62.8 0.0 2.4 2 0 0 2 2 2 2 16S rRNA methyltransferase RsmB/F Methyltransf_31 PF13847.6 ELR24489.1 - 8.8e-07 28.8 0.0 0.0002 21.2 0.0 2.8 3 0 0 3 3 3 1 Methyltransferase domain Methyltransf_25 PF13649.6 ELR24489.1 - 1.6e-06 28.8 0.3 1.7e-05 25.4 0.0 2.7 3 0 0 3 3 3 1 Methyltransferase domain Methyltransf_23 PF13489.6 ELR24489.1 - 8.1e-06 25.8 0.0 0.058 13.2 0.0 2.2 2 0 0 2 2 2 2 Methyltransferase domain CDC45 PF02724.14 ELR24489.1 - 3.5e-05 22.3 0.7 4.8e-05 21.9 0.7 1.1 1 0 0 1 1 1 1 CDC45-like protein FtsJ PF01728.19 ELR24489.1 - 4.8e-05 23.5 0.1 0.00015 21.9 0.1 1.7 1 1 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_11 PF08241.12 ELR24489.1 - 0.0018 18.9 0.2 1.4 9.6 0.1 3.0 3 0 0 3 3 3 1 Methyltransferase domain Ubie_methyltran PF01209.18 ELR24489.1 - 0.0095 15.3 0.0 0.038 13.3 0.0 1.8 2 0 0 2 2 2 1 ubiE/COQ5 methyltransferase family Nop14 PF04147.12 ELR24489.1 - 0.033 12.4 6.8 0.045 12.0 6.8 1.0 1 0 0 1 1 1 0 Nop14-like family MTS PF05175.14 ELR24489.1 - 0.081 12.5 0.1 0.27 10.8 0.1 1.7 2 0 0 2 2 2 0 Methyltransferase small domain PCMT PF01135.19 ELR24489.1 - 0.1 12.3 0.0 0.23 11.2 0.0 1.5 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) DUF4746 PF15928.5 ELR24489.1 - 0.16 11.3 3.5 0.25 10.7 3.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) DUF4637 PF15470.6 ELR24489.1 - 0.17 11.6 9.7 0.31 10.7 9.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) Methyltransf_4 PF02390.17 ELR24489.1 - 0.27 10.7 1.0 0.97 8.9 0.0 2.4 2 1 1 3 3 3 0 Putative methyltransferase Paf1 PF03985.13 ELR24489.1 - 0.5 9.3 8.4 0.69 8.8 8.4 1.1 1 0 0 1 1 1 0 Paf1 TRAP_alpha PF03896.16 ELR24489.1 - 1 8.5 3.5 1.8 7.7 3.5 1.4 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Protamine_P2 PF00841.19 ELR24489.1 - 1.9 9.0 7.0 3.6 8.1 7.0 1.3 1 0 0 1 1 1 0 Sperm histone P2 FAM176 PF14851.6 ELR24489.1 - 2.1 8.0 5.7 3.6 7.2 5.7 1.3 1 0 0 1 1 1 0 FAM176 family DNA_pol_phi PF04931.13 ELR24489.1 - 3.5 5.6 9.4 4.9 5.1 9.4 1.1 1 0 0 1 1 1 0 DNA polymerase phi NOA36 PF06524.12 ELR24489.1 - 8.8 5.5 9.5 16 4.7 9.5 1.3 1 0 0 1 1 1 0 NOA36 protein Ssu72 PF04722.13 ELR24490.1 - 1.9e-73 246.1 0.1 2.1e-73 245.9 0.1 1.0 1 0 0 1 1 1 1 Ssu72-like protein Pkinase_Tyr PF07714.17 ELR24491.1 - 6.7e-36 123.9 0.0 1e-35 123.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ELR24491.1 - 3e-31 108.8 0.0 5.1e-31 108.0 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Kinase-like PF14531.6 ELR24491.1 - 0.00095 18.6 0.0 0.0018 17.7 0.0 1.4 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 ELR24491.1 - 0.011 15.7 0.0 0.023 14.7 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family DUF2052 PF09747.9 ELR24492.1 - 1.2 9.2 21.7 1.5 9.0 21.7 1.1 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) CDC45 PF02724.14 ELR24492.1 - 3.8 5.7 17.5 4.2 5.6 17.5 1.1 1 0 0 1 1 1 0 CDC45-like protein GAGA_bind PF06217.12 ELR24492.1 - 5.3 7.2 12.4 6.8 6.9 12.4 1.1 1 0 0 1 1 1 0 GAGA binding protein-like family SRP-alpha_N PF04086.13 ELR24492.1 - 5.4 6.9 18.0 5.7 6.8 18.0 1.1 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal Paf1 PF03985.13 ELR24492.1 - 8.8 5.2 20.0 9.6 5.1 20.0 1.3 1 0 0 1 1 1 0 Paf1 LRR_4 PF12799.7 ELR24493.1 - 8.1e-07 29.3 6.1 0.58 10.7 0.3 7.8 8 1 1 9 9 9 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 ELR24493.1 - 2.8 7.8 14.2 7.1 6.5 0.0 6.3 6 2 1 7 7 7 0 Leucine rich repeat Sec15 PF04091.12 ELR24494.1 - 2.9e-22 79.5 2.7 6.2e-22 78.4 2.7 1.4 1 0 0 1 1 1 1 Exocyst complex subunit Sec15-like ZZ PF00569.17 ELR24494.1 - 3.1e-05 23.7 8.5 5.8e-05 22.8 8.5 1.4 1 0 0 1 1 1 1 Zinc finger, ZZ type DUF5051 PF16473.5 ELR24494.1 - 0.023 14.7 0.2 0.07 13.1 0.2 1.8 1 0 0 1 1 1 0 3' exoribonuclease, RNase T-like partial_CstF PF15861.5 ELR24495.1 - 0.032 14.0 0.0 0.057 13.2 0.0 1.4 1 0 0 1 1 1 0 Partial cleavage stimulation factor domain SR-25 PF10500.9 ELR24495.1 - 3.1 7.3 7.5 5.7 6.5 7.5 1.4 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein DUF1216 PF06746.11 ELR24498.1 - 0.13 12.3 0.0 0.18 11.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1216) Dam PF05869.11 ELR24499.1 - 0.00066 19.3 0.0 0.00086 18.9 0.0 1.2 1 0 0 1 1 1 1 DNA N-6-adenine-methyltransferase (Dam) Peptidase_C1 PF00112.23 ELR24500.1 - 1.7e-64 217.9 5.4 2.1e-64 217.6 5.4 1.1 1 0 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.12 ELR24500.1 - 1.8e-14 53.9 3.0 1.8e-14 53.9 3.0 1.9 3 0 0 3 3 3 1 Cathepsin propeptide inhibitor domain (I29) Peptidase_C1_2 PF03051.15 ELR24500.1 - 0.015 14.1 0.2 0.024 13.4 0.2 1.2 1 0 0 1 1 1 0 Peptidase C1-like family kleA_kleC PF17383.2 ELR24501.1 - 0.028 14.7 0.5 0.078 13.3 0.1 1.9 2 0 0 2 2 2 0 Uncharacterized KorC regulated protein A NT-C2 PF10358.9 ELR24502.1 - 1.1e-16 60.8 1.7 1.1e-16 60.8 1.7 2.2 3 0 0 3 3 3 1 N-terminal C2 in EEIG1 and EHBP1 proteins DIL PF01843.19 ELR24502.1 - 7.3e-11 42.3 1.3 2e-09 37.7 0.0 3.5 3 1 0 3 3 3 1 DIL domain GIT_CC PF16559.5 ELR24502.1 - 0.00023 21.0 21.2 0.082 12.8 2.7 3.9 3 0 0 3 3 3 3 GIT coiled-coil Rho guanine nucleotide exchange factor DUF4201 PF13870.6 ELR24502.1 - 0.02 14.6 0.8 0.02 14.6 0.8 3.6 2 1 0 3 3 3 0 Domain of unknown function (DUF4201) WDCP PF15390.6 ELR24502.1 - 1.9 6.7 11.9 15 3.8 0.0 2.4 2 0 0 2 2 2 0 WD repeat and coiled-coil-containing protein family HrpB7 PF09486.10 ELR24502.1 - 5.8 7.3 22.3 1.6 9.1 13.6 2.5 2 0 0 2 2 2 0 Bacterial type III secretion protein (HrpB7) zf-C3HC4_3 PF13920.6 ELR24503.1 - 2.2e-12 46.6 13.0 4e-12 45.8 13.0 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) DUF1681 PF07933.14 ELR24503.1 - 1e-06 28.5 0.0 1.6e-06 27.9 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1681) Prok-RING_4 PF14447.6 ELR24503.1 - 7.9e-05 22.4 13.1 0.00014 21.7 13.1 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 SH3_2 PF07653.17 ELR24503.1 - 0.0001 21.9 0.1 0.00021 20.9 0.1 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 ELR24503.1 - 0.00013 21.5 1.2 0.00042 19.9 0.9 2.0 2 1 0 2 2 2 1 SH3 domain zf-RING_2 PF13639.6 ELR24503.1 - 0.00062 20.0 15.2 0.0012 19.1 15.2 1.5 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.6 ELR24503.1 - 0.046 13.7 14.8 0.1 12.6 14.8 1.6 1 0 0 1 1 1 0 zinc-RING finger domain SH3_9 PF14604.6 ELR24503.1 - 0.048 13.5 0.0 0.11 12.4 0.0 1.6 1 0 0 1 1 1 0 Variant SH3 domain GAGA PF09237.11 ELR24503.1 - 0.067 13.0 1.8 0.18 11.6 1.8 1.8 1 0 0 1 1 1 0 GAGA factor zf-C3HC4 PF00097.25 ELR24503.1 - 0.071 13.0 16.5 0.14 12.1 16.5 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) BTB_2 PF02214.22 ELR24504.1 - 1.3e-12 47.9 0.1 6.7e-07 29.6 0.0 2.3 1 1 0 2 2 2 2 BTB/POZ domain BTB PF00651.31 ELR24504.1 - 0.0012 19.0 0.0 0.16 12.2 0.0 2.3 2 0 0 2 2 2 2 BTB/POZ domain LOH1CR12 PF10158.9 ELR24505.1 - 1.5e-07 31.5 0.3 2.4e-07 30.9 0.3 1.2 1 0 0 1 1 1 1 Tumour suppressor protein E7R PF17467.2 ELR24506.1 - 0.062 13.5 2.8 4.3 7.6 0.0 2.3 2 0 0 2 2 2 0 Viral Protein E7 DUF4349 PF14257.6 ELR24507.1 - 0.07 12.6 0.9 0.11 11.9 0.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4349) TatD_DNase PF01026.21 ELR24509.1 - 2.4e-61 207.3 0.2 2.8e-61 207.1 0.2 1.0 1 0 0 1 1 1 1 TatD related DNase Amidohydro_2 PF04909.14 ELR24509.1 - 1e-05 25.5 0.1 1.6e-05 24.9 0.1 1.5 1 1 0 1 1 1 1 Amidohydrolase Y2_Tnp PF04986.13 ELR24509.1 - 0.093 12.8 0.2 0.74 9.8 0.2 2.0 1 1 0 1 1 1 0 Putative transposase DUF5095 PF17016.5 ELR24509.1 - 0.13 11.9 0.0 0.19 11.4 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF5095) SWIRM-assoc_1 PF16495.5 ELR24511.1 - 0.0056 16.6 20.3 0.043 13.8 1.0 3.6 1 1 1 3 3 3 2 SWIRM-associated region 1 TPR_MLP1_2 PF07926.12 ELR24511.1 - 0.091 12.8 30.0 1.4 9.0 22.8 2.9 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein APG6_N PF17675.1 ELR24511.1 - 0.19 12.2 35.4 1.4 9.5 22.0 2.1 1 1 1 2 2 2 0 Apg6 coiled-coil region Spc7 PF08317.11 ELR24511.1 - 0.24 10.3 27.2 0.04 12.8 17.4 2.0 1 1 1 2 2 2 0 Spc7 kinetochore protein Atg14 PF10186.9 ELR24511.1 - 0.76 8.8 17.3 0.57 9.2 16.1 1.4 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 RNA_lig_T4_1 PF09511.10 ELR24512.1 - 4.7e-21 75.7 0.0 7.6e-21 75.0 0.0 1.3 1 0 0 1 1 1 1 RNA ligase Poxvirus_B22R_N PF13169.6 ELR24512.1 - 0.0029 18.1 0.1 0.014 15.9 0.0 2.1 2 1 1 3 3 3 1 Poxvirus B22R protein N-terminal DUF1566 PF07603.11 ELR24512.1 - 0.012 16.0 0.0 0.026 14.9 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1566) SIR2_2 PF13289.6 ELR24513.1 - 2.4e-09 37.4 0.0 3.4e-09 37.0 0.0 1.3 1 0 0 1 1 1 1 SIR2-like domain DUF86 PF01934.17 ELR24513.1 - 0.091 12.6 0.0 0.16 11.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function DUF86 START PF01852.19 ELR24514.1 - 1.1e-10 41.2 0.0 2.2e-10 40.3 0.0 1.4 1 0 0 1 1 1 1 START domain DUF3987 PF13148.6 ELR24514.1 - 0.07 12.1 0.1 0.19 10.7 0.1 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3987) Peptidase_S8 PF00082.22 ELR24515.1 - 4.7e-36 124.6 10.0 9.9e-36 123.5 10.0 1.4 1 1 0 1 1 1 1 Subtilase family TFIIF_alpha PF05793.12 ELR24516.1 - 2.1e-09 36.5 52.8 0.016 13.9 33.2 2.8 1 1 1 2 2 2 2 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Med3 PF11593.8 ELR24516.1 - 3.9 6.6 11.1 5.8 6.0 11.1 1.2 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal ADH_N PF08240.12 ELR24517.1 - 3.5e-25 88.0 3.5 3.5e-25 88.0 3.5 1.9 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 ELR24517.1 - 1.1e-21 77.1 0.4 2.5e-21 76.0 0.4 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 ELR24517.1 - 3.3e-07 30.0 2.9 0.0018 17.8 0.1 2.3 1 1 0 2 2 2 2 Glucose dehydrogenase C-terminus PALP PF00291.25 ELR24517.1 - 0.00025 20.6 2.8 0.00038 19.9 2.8 1.2 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Astro_capsid_N PF03115.14 ELR24517.1 - 0.1 11.3 0.9 0.16 10.6 0.9 1.2 1 0 0 1 1 1 0 Astrovirus capsid protein precursor 2-Hacid_dh_C PF02826.19 ELR24517.1 - 0.11 11.8 0.0 0.19 11.1 0.0 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Cpn10 PF00166.21 ELR24517.1 - 0.17 12.0 1.4 0.63 10.1 0.2 2.3 2 0 0 2 2 2 0 Chaperonin 10 Kd subunit FeoA PF04023.14 ELR24517.1 - 0.73 10.1 3.1 3 8.2 0.1 2.9 3 0 0 3 3 3 0 FeoA domain Glycogen_syn PF05693.13 ELR24518.1 - 4.1e-260 864.8 0.1 5.1e-260 864.5 0.1 1.0 1 0 0 1 1 1 1 Glycogen synthase Glycos_transf_1 PF00534.20 ELR24518.1 - 6e-07 29.2 0.0 8.4e-06 25.4 0.0 2.2 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 ELR24518.1 - 3.8e-05 24.1 0.0 0.0022 18.4 0.0 2.4 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 ELR24518.1 - 0.00036 20.6 0.2 0.00084 19.4 0.2 1.6 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_trans_4_4 PF13579.6 ELR24518.1 - 0.0011 19.4 0.9 0.0024 18.3 0.9 1.5 1 0 0 1 1 1 1 Glycosyl transferase 4-like domain ThiS-like PF14453.6 ELR24518.1 - 0.037 14.1 0.0 0.078 13.0 0.0 1.5 1 0 0 1 1 1 0 ThiS-like ubiquitin Ras PF00071.22 ELR24519.1 - 5.4e-37 126.9 0.6 6.3e-37 126.7 0.6 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR24519.1 - 1.3e-16 60.9 0.0 2.8e-16 59.8 0.0 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR24519.1 - 1.4e-06 27.9 0.1 1.9e-06 27.5 0.1 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 ELR24519.1 - 1.6e-05 24.5 0.1 2.9e-05 23.7 0.1 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 ELR24519.1 - 0.023 14.8 0.1 0.051 13.6 0.1 1.8 1 1 0 1 1 1 0 50S ribosome-binding GTPase Voldacs PF03517.13 ELR24519.1 - 0.066 13.3 0.4 0.075 13.2 0.4 1.1 1 0 0 1 1 1 0 Regulator of volume decrease after cellular swelling Gtr1_RagA PF04670.12 ELR24519.1 - 0.069 12.5 0.0 0.09 12.1 0.0 1.1 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region DUF5067 PF16729.5 ELR24519.1 - 0.2 11.6 11.0 11 5.9 0.0 3.1 2 1 1 3 3 3 0 Domain of unknown function (DUF5067) Got1 PF04178.12 ELR24520.1 - 1.9e-17 63.7 12.8 2.3e-17 63.4 12.8 1.1 1 0 0 1 1 1 1 Got1/Sft2-like family DUF3040 PF11239.8 ELR24520.1 - 9.5 6.6 14.3 1.3e+03 -0.3 14.3 2.8 1 1 0 1 1 1 0 Protein of unknown function (DUF3040) PI3_PI4_kinase PF00454.27 ELR24521.1 - 3.1e-31 109.1 0.0 1.7e-28 100.1 0.0 2.3 1 1 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase 4HBT_3 PF13622.6 ELR24521.1 - 0.0048 17.2 0.5 0.013 15.8 0.5 1.7 1 0 0 1 1 1 1 Thioesterase-like superfamily SR-25 PF10500.9 ELR24521.1 - 0.083 12.5 6.3 0.2 11.2 6.3 1.6 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein ArsC PF03960.15 ELR24522.1 - 1.3e-10 41.1 0.1 3.5e-10 39.7 0.1 1.7 1 0 0 1 1 1 1 ArsC family DTHCT PF08070.11 ELR24522.1 - 0.08 13.7 2.1 1.4 9.7 2.1 2.5 1 1 0 1 1 1 0 DTHCT (NUC029) region Kelch_3 PF13415.6 ELR24523.1 - 5e-42 141.4 16.1 5.9e-09 36.0 0.2 7.2 5 1 1 6 6 6 6 Galactose oxidase, central domain Kelch_4 PF13418.6 ELR24523.1 - 6.9e-41 138.0 16.6 9.9e-09 35.1 0.0 6.4 5 1 1 6 6 6 6 Galactose oxidase, central domain Kelch_1 PF01344.25 ELR24523.1 - 9.5e-36 121.1 7.8 4.6e-09 35.7 0.0 6.6 5 1 1 6 6 6 6 Kelch motif Kelch_5 PF13854.6 ELR24523.1 - 1.1e-32 111.5 10.3 1.1e-06 28.4 0.0 6.6 5 1 1 6 6 6 6 Kelch motif Kelch_6 PF13964.6 ELR24523.1 - 1.2e-30 104.8 9.2 5.2e-06 26.5 0.0 6.5 3 1 3 6 6 6 5 Kelch motif Kelch_2 PF07646.15 ELR24523.1 - 4.5e-26 89.8 10.2 4.7e-05 23.2 0.0 6.5 5 1 1 6 6 6 6 Kelch motif SAM_1 PF00536.30 ELR24523.1 - 5.6e-17 61.9 0.1 8.5e-17 61.4 0.1 1.3 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 ELR24523.1 - 3.1e-12 46.4 0.0 5.4e-12 45.6 0.0 1.3 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Dscam_C PF12355.8 ELR24523.1 - 0.089 13.8 3.5 0.2 12.6 2.3 2.1 2 0 0 2 2 2 0 Down syndrome cell adhesion molecule C terminal CAP_N PF01213.19 ELR24523.1 - 1.1 8.7 3.3 1.8 8.0 3.3 1.2 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal eIF-5a PF01287.20 ELR24524.1 - 8.6e-07 29.0 0.0 1.7e-06 28.0 0.0 1.5 1 1 0 1 1 1 1 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold DUF951 PF06107.11 ELR24524.1 - 0.058 13.3 2.2 0.25 11.3 0.2 2.4 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF951) DUF1924 PF09086.11 ELR24524.1 - 0.11 12.9 0.1 0.65 10.4 0.0 2.2 1 1 0 2 2 2 0 Domain of unknown function (DUF1924) F-box-like PF12937.7 ELR24525.1 - 3.7e-08 33.1 4.7 6.3e-08 32.4 0.9 2.5 3 0 0 3 3 3 1 F-box-like F-box PF00646.33 ELR24525.1 - 3.1e-06 26.9 0.8 6.2e-06 25.9 0.8 1.5 1 0 0 1 1 1 1 F-box domain DUF2456 PF10445.9 ELR24526.1 - 0.00039 20.4 5.0 0.00039 20.4 5.0 2.2 2 1 0 2 2 2 1 Protein of unknown function (DUF2456) Sel1 PF08238.12 ELR24528.1 - 1.5e-20 73.1 9.9 1.3e-06 28.9 0.1 5.7 5 0 0 5 5 5 4 Sel1 repeat Pro_isomerase PF00160.21 ELR24529.1 - 1.3e-35 123.1 0.2 1.3e-35 123.1 0.2 2.6 2 1 0 2 2 2 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD WAC_Acf1_DNA_bd PF10537.9 ELR24530.1 - 1.2e-20 73.9 0.4 1.2e-20 73.9 0.4 2.9 3 1 0 3 3 2 1 ATP-utilising chromatin assembly and remodelling N-terminal WSD PF15613.6 ELR24530.1 - 2e-12 47.5 33.8 1.5e-10 41.5 28.5 3.9 2 1 0 2 2 2 1 Williams-Beuren syndrome DDT (WSD), D-TOX E motif DDT PF02791.17 ELR24530.1 - 3.3e-08 33.7 0.0 7.6e-08 32.5 0.0 1.7 1 0 0 1 1 1 1 DDT domain DUF2201_N PF13203.6 ELR24530.1 - 1e-05 25.3 1.6 9e-05 22.2 0.1 2.6 2 1 0 2 2 2 1 Putative metallopeptidase domain WHIM1 PF15612.6 ELR24530.1 - 0.036 13.6 0.0 0.072 12.7 0.0 1.5 1 0 0 1 1 1 0 WSTF, HB1, Itc1p, MBD9 motif 1 Na_trans_assoc PF06512.13 ELR24530.1 - 0.046 14.0 28.0 0.094 13.0 23.8 2.5 2 1 0 2 2 2 0 Sodium ion transport-associated Zip PF02535.22 ELR24530.1 - 0.32 10.2 18.3 0.14 11.4 13.3 2.7 3 0 0 3 3 3 0 ZIP Zinc transporter Acetyltransf_9 PF13527.7 ELR24530.1 - 0.33 11.0 2.8 1.2 9.3 0.1 3.1 4 0 0 4 4 4 0 Acetyltransferase (GNAT) domain Presenilin PF01080.17 ELR24530.1 - 7 5.3 30.9 3.5 6.3 25.7 2.2 3 0 0 3 3 3 0 Presenilin GREB1 PF15782.5 ELR24530.1 - 7.6 3.5 9.4 9.2 3.2 9.4 1.2 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer SLC12 PF03522.15 ELR24530.1 - 7.9 5.4 27.0 8.3 5.3 19.8 2.2 2 0 0 2 2 2 0 Solute carrier family 12 Methyltransf_31 PF13847.6 ELR24531.1 - 1.6e-30 106.0 0.0 2.3e-30 105.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ELR24531.1 - 5.6e-22 78.2 0.0 1.2e-21 77.2 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ELR24531.1 - 1.7e-21 76.7 0.1 3.4e-21 75.8 0.1 1.5 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 ELR24531.1 - 4e-18 65.6 0.1 5.9e-18 65.0 0.1 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_23 PF13489.6 ELR24531.1 - 9.8e-12 45.0 0.0 1.5e-11 44.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ELR24531.1 - 5.1e-11 43.2 0.0 8.7e-11 42.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 ELR24531.1 - 5.1e-07 29.7 0.0 8e-07 29.0 0.0 1.4 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) PrmA PF06325.13 ELR24531.1 - 1.5e-06 27.9 0.2 2.2e-06 27.3 0.2 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_8 PF05148.15 ELR24531.1 - 1.2e-05 25.3 0.3 4.7e-05 23.3 0.3 1.9 1 1 0 1 1 1 1 Hypothetical methyltransferase Methyltransf_32 PF13679.6 ELR24531.1 - 8.2e-05 22.6 0.0 0.00026 21.0 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 ELR24531.1 - 0.0012 18.2 0.0 0.0017 17.7 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase DOT1 PF08123.13 ELR24531.1 - 0.0014 18.2 0.2 0.0024 17.5 0.2 1.3 1 0 0 1 1 1 1 Histone methylation protein DOT1 FtsJ PF01728.19 ELR24531.1 - 0.0042 17.2 0.3 0.0088 16.2 0.3 1.6 1 1 0 1 1 1 1 FtsJ-like methyltransferase UPF0020 PF01170.18 ELR24531.1 - 0.0063 16.2 0.0 0.012 15.3 0.0 1.4 1 0 0 1 1 1 1 Putative RNA methylase family UPF0020 Methyltransf_16 PF10294.9 ELR24531.1 - 0.042 13.6 0.3 0.065 13.0 0.3 1.2 1 0 0 1 1 1 0 Lysine methyltransferase Methyltransf_15 PF09445.10 ELR24531.1 - 0.071 12.7 0.1 0.11 12.1 0.1 1.2 1 0 0 1 1 1 0 RNA cap guanine-N2 methyltransferase Acyl-CoA_dh_N PF02771.16 ELR24535.1 - 6.3e-27 94.5 0.0 1.2e-26 93.6 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_1 PF00441.24 ELR24535.1 - 2.3e-26 92.8 0.5 3.7e-26 92.1 0.5 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 ELR24535.1 - 4.1e-23 81.4 0.1 7.2e-23 80.6 0.1 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.11 ELR24535.1 - 1.3e-07 32.0 0.2 3.7e-07 30.5 0.0 1.8 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_ox_N PF14749.6 ELR24535.1 - 0.086 13.4 0.0 0.16 12.5 0.0 1.5 1 0 0 1 1 1 0 Acyl-coenzyme A oxidase N-terminal zf-UBP PF02148.19 ELR24536.1 - 1.1e-06 28.9 0.1 2.1e-06 28.0 0.1 1.5 1 0 0 1 1 1 1 Zn-finger in ubiquitin-hydrolases and other protein UCH PF00443.29 ELR24536.1 - 0.00055 19.5 0.0 0.0009 18.8 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase CHASE PF03924.13 ELR24536.1 - 0.025 14.5 0.0 0.043 13.8 0.0 1.3 1 0 0 1 1 1 0 CHASE domain RVT_2 PF07727.14 ELR24538.1 - 4.3e-06 26.6 0.0 0.0086 15.7 0.0 2.0 2 0 0 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 ELR24539.1 - 4e-15 56.0 0.0 5.1e-14 52.5 0.0 2.3 2 0 0 2 2 2 1 Integrase core domain gag_pre-integrs PF13976.6 ELR24539.1 - 2.9e-07 30.2 0.1 6e-07 29.2 0.1 1.6 1 0 0 1 1 1 1 GAG-pre-integrase domain CDP-OH_P_transf PF01066.21 ELR24540.1 - 2.1e-16 60.4 0.1 2.1e-16 60.4 0.1 2.9 3 1 0 3 3 3 1 CDP-alcohol phosphatidyltransferase Proteasome PF00227.26 ELR24542.1 - 1e-59 201.2 0.0 1.2e-59 201.0 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 ELR24542.1 - 2.2e-13 49.6 0.2 4e-13 48.8 0.2 1.4 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature DWNN PF08783.11 ELR24543.1 - 3.9e-21 75.1 0.5 4.5e-21 74.9 0.5 1.0 1 0 0 1 1 1 1 DWNN domain zf-CCHC_2 PF13696.6 ELR24544.1 - 5.4e-08 32.5 7.8 9.9e-08 31.7 7.8 1.5 1 0 0 1 1 1 1 Zinc knuckle zf-C3HC4_2 PF13923.6 ELR24544.1 - 3.3e-05 23.6 10.2 6.4e-05 22.7 10.2 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ELR24544.1 - 0.009 16.0 8.5 0.02 14.8 8.5 1.6 1 0 0 1 1 1 1 zinc-RING finger domain zf-CCHC PF00098.23 ELR24544.1 - 0.015 15.4 2.7 0.033 14.3 2.7 1.6 1 0 0 1 1 1 0 Zinc knuckle zf-RING_2 PF13639.6 ELR24544.1 - 0.056 13.8 9.6 0.12 12.8 9.6 1.5 1 0 0 1 1 1 0 Ring finger domain zf-C3HC4_3 PF13920.6 ELR24544.1 - 0.088 12.7 12.6 0.014 15.3 8.7 1.7 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 ELR24544.1 - 0.22 11.4 9.4 0.39 10.6 9.4 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 ELR24544.1 - 0.52 10.5 9.5 0.96 9.7 9.5 1.4 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.6 ELR24544.1 - 0.55 10.3 6.8 1.1 9.4 6.8 1.5 1 0 0 1 1 1 0 RING-type zinc-finger zf-RING_6 PF14835.6 ELR24544.1 - 0.92 9.4 5.2 1.7 8.6 5.2 1.3 1 0 0 1 1 1 0 zf-RING of BARD1-type protein Pkinase PF00069.25 ELR24545.1 - 5.7e-72 242.3 0.0 8.2e-72 241.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR24545.1 - 3.7e-29 101.8 0.0 5.7e-29 101.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ELR24545.1 - 2.3e-05 23.8 0.0 0.00022 20.6 0.0 2.2 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.14 ELR24545.1 - 0.00074 18.9 0.0 0.0014 18.1 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 ELR24545.1 - 0.024 13.4 0.0 0.038 12.8 0.0 1.3 1 0 0 1 1 1 0 Fungal protein kinase COX6B PF02297.17 ELR24546.1 - 5.6e-13 48.9 4.2 1.2e-12 47.9 4.2 1.5 1 0 0 1 1 1 1 Cytochrome oxidase c subunit VIb MYT1 PF08474.11 ELR24546.1 - 0.17 11.8 8.4 0.39 10.6 8.4 1.5 1 1 0 1 1 1 0 Myelin transcription factor 1 zf_Hakai PF18408.1 ELR24546.1 - 0.21 11.3 0.9 0.37 10.5 0.9 1.3 1 0 0 1 1 1 0 C2H2 Hakai zinc finger domain ATP-synt_ab PF00006.25 ELR24547.1 - 8.5e-109 362.2 0.0 1.3e-108 361.6 0.0 1.3 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_Xtn PF16886.5 ELR24547.1 - 4.6e-44 149.2 0.0 8.4e-44 148.3 0.0 1.4 1 0 0 1 1 1 1 ATPsynthase alpha/beta subunit N-term extension ATP-synt_ab_N PF02874.23 ELR24547.1 - 2.4e-11 44.0 0.9 7.8e-11 42.3 0.9 2.0 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain Mito_carr PF00153.27 ELR24548.1 - 2.6e-59 197.2 0.2 4.1e-20 71.5 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Glyco_hydro_53 PF07745.13 ELR24549.1 - 0.06 12.3 0.3 0.1 11.6 0.3 1.3 1 0 0 1 1 1 0 Glycosyl hydrolase family 53 ArfGap PF01412.18 ELR24550.1 - 8.6e-29 100.0 0.1 1.1e-28 99.6 0.1 1.1 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf zf-B_box PF00643.24 ELR24550.1 - 0.001 19.1 4.0 0.0016 18.5 4.0 1.3 1 0 0 1 1 1 1 B-box zinc finger Ribosomal_L7Ae PF01248.26 ELR24551.1 - 1e-08 34.8 0.0 2.2e-08 33.7 0.0 1.5 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family RNase_P_pop3 PF08228.11 ELR24551.1 - 0.00021 21.4 0.0 0.00046 20.3 0.0 1.6 1 0 0 1 1 1 1 RNase P subunit Pop3 NAD_binding_4 PF07993.12 ELR24552.1 - 1.2e-66 224.6 0.0 1.7e-66 224.0 0.0 1.2 1 0 0 1 1 1 1 Male sterility protein Sterile PF03015.19 ELR24552.1 - 1.9e-23 82.5 1.0 4.4e-23 81.3 1.0 1.7 1 0 0 1 1 1 1 Male sterility protein Acyltransferase PF01553.21 ELR24552.1 - 3e-21 75.5 0.0 6.9e-21 74.3 0.0 1.6 1 0 0 1 1 1 1 Acyltransferase Epimerase PF01370.21 ELR24552.1 - 1.9e-05 24.2 0.0 4.2e-05 23.1 0.0 1.5 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 ELR24552.1 - 0.0018 17.7 0.3 0.037 13.4 0.3 2.3 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase Polysacc_synt_2 PF02719.15 ELR24552.1 - 0.95 8.5 2.5 4.7 6.3 2.5 2.0 1 1 0 1 1 1 0 Polysaccharide biosynthesis protein MMR_HSR1 PF01926.23 ELR24553.1 - 2.3e-07 30.9 0.0 5.3e-07 29.7 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 ELR24553.1 - 0.00019 21.4 0.3 0.00089 19.2 0.0 2.0 2 0 0 2 2 2 1 RsgA GTPase AIG1 PF04548.16 ELR24553.1 - 0.0058 16.0 0.0 0.12 11.7 0.0 2.1 1 1 1 2 2 2 1 AIG1 family CARDB PF07705.11 ELR24553.1 - 0.025 14.8 0.0 0.053 13.8 0.0 1.5 1 0 0 1 1 1 0 CARDB DUF815 PF05673.13 ELR24553.1 - 0.13 11.4 0.0 0.31 10.2 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF815) Integrin_b_cyt PF08725.11 ELR24554.1 - 0.46 10.2 1.3 4.5 7.0 0.0 2.2 2 0 0 2 2 2 0 Integrin beta cytoplasmic domain NAPRTase_N PF17767.1 ELR24555.1 - 5.2e-38 130.2 0.1 1.9e-37 128.5 0.0 1.9 2 0 0 2 2 2 1 Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain NAPRTase_C PF17956.1 ELR24555.1 - 2.4e-37 127.7 0.0 4.3e-37 126.9 0.0 1.4 1 0 0 1 1 1 1 Nicotinate phosphoribosyltransferase C-terminal domain NAPRTase PF04095.16 ELR24555.1 - 0.0018 17.9 0.0 0.0079 15.8 0.0 1.8 2 0 0 2 2 2 1 Nicotinate phosphoribosyltransferase (NAPRTase) family YABBY PF04690.13 ELR24556.1 - 0.014 16.0 0.8 0.031 14.9 0.8 1.5 1 0 0 1 1 1 0 YABBY protein AP3D1 PF06375.11 ELR24556.1 - 0.74 10.0 8.0 1.3 9.2 4.3 2.4 2 0 0 2 2 2 0 AP-3 complex subunit delta-1 DUF1631 PF07793.11 ELR24557.1 - 0.011 14.3 0.3 0.013 14.0 0.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1631) 2OG-FeII_Oxy_3 PF13640.6 ELR24558.1 - 3.8e-07 30.9 0.0 9.8e-07 29.6 0.0 1.6 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_5 PF13759.6 ELR24558.1 - 0.063 13.7 0.0 0.13 12.7 0.0 1.5 1 0 0 1 1 1 0 Putative 2OG-Fe(II) oxygenase VIT PF08487.10 ELR24559.1 - 6.9e-39 132.5 1.1 1.8e-38 131.2 1.1 1.8 1 0 0 1 1 1 1 Vault protein inter-alpha-trypsin domain VWA_3 PF13768.6 ELR24559.1 - 6.7e-31 107.3 0.0 1.2e-30 106.6 0.0 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.28 ELR24559.1 - 2e-16 60.7 0.0 4.2e-16 59.7 0.0 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain VIT_2 PF13757.6 ELR24559.1 - 3.8e-13 49.1 0.0 7.5e-13 48.2 0.0 1.5 1 0 0 1 1 1 1 Vault protein inter-alpha-trypsin domain VWA_2 PF13519.6 ELR24559.1 - 5.1e-12 46.4 0.0 1.4e-11 45.0 0.0 1.8 1 0 0 1 1 1 1 von Willebrand factor type A domain DUF2201 PF09967.9 ELR24559.1 - 0.014 15.5 0.0 0.081 13.1 0.0 2.3 1 1 0 1 1 1 0 VWA-like domain (DUF2201) VWA_CoxE PF05762.14 ELR24559.1 - 0.05 13.0 0.0 0.089 12.2 0.0 1.4 1 0 0 1 1 1 0 VWA domain containing CoxE-like protein CN_hydrolase PF00795.22 ELR24560.1 - 8.5e-12 45.0 0.0 2.2e-11 43.6 0.0 1.8 1 1 0 1 1 1 1 Carbon-nitrogen hydrolase CLU PF13236.6 ELR24561.1 - 1.3e-48 165.7 0.0 9.1e-48 163.0 0.0 2.2 3 0 0 3 3 3 1 Clustered mitochondria eIF3_p135 PF12807.7 ELR24561.1 - 7.5e-10 39.1 1.0 1.1e-09 38.6 0.1 1.7 2 0 0 2 2 2 1 Translation initiation factor eIF3 subunit 135 Zn_peptidase PF04228.13 ELR24562.1 - 0.059 12.8 0.0 0.067 12.6 0.0 1.0 1 0 0 1 1 1 0 Putative neutral zinc metallopeptidase SNARE PF05739.19 ELR24562.1 - 1.4 8.9 6.2 27 4.9 1.7 2.8 2 1 1 3 3 3 0 SNARE domain DNA_pol_phi PF04931.13 ELR24563.1 - 0.083 11.0 0.3 0.11 10.6 0.3 1.2 1 0 0 1 1 1 0 DNA polymerase phi ORC6 PF05460.13 ELR24563.1 - 0.38 10.0 5.0 0.25 10.6 3.8 1.3 1 1 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) CDC45 PF02724.14 ELR24563.1 - 1.3 7.3 3.1 1.2 7.4 3.1 1.1 1 0 0 1 1 1 0 CDC45-like protein Gag_p12 PF01141.18 ELR24563.1 - 3.2 8.2 6.9 3.5 8.0 4.5 2.0 1 1 1 2 2 2 0 Gag polyprotein, inner coat protein p12 TFIIE-A_C PF11521.8 ELR24563.1 - 5.9 7.3 11.0 16 5.8 0.1 2.2 2 0 0 2 2 2 0 C-terminal general transcription factor TFIIE alpha COMM_domain PF07258.14 ELR24564.1 - 4.2e-14 52.4 1.1 6e-14 51.9 1.1 1.2 1 0 0 1 1 1 1 COMM domain Pkinase PF00069.25 ELR24565.1 - 1e-52 179.1 0.1 6.1e-47 160.2 0.0 2.4 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ELR24565.1 - 1.7e-31 109.4 0.2 5.3e-30 104.6 0.1 2.1 1 1 1 2 2 2 1 Protein tyrosine kinase PBD PF00786.28 ELR24565.1 - 1.7e-15 57.1 0.0 4e-15 55.9 0.0 1.6 1 0 0 1 1 1 1 P21-Rho-binding domain Pkinase_fungal PF17667.1 ELR24565.1 - 0.00047 19.1 2.8 0.0041 16.0 0.0 2.4 3 0 0 3 3 3 1 Fungal protein kinase PPL5 PF18168.1 ELR24565.1 - 0.43 9.8 4.9 0.65 9.2 4.9 1.2 1 0 0 1 1 1 0 Prim-pol family 5 DUF3340 PF11818.8 ELR24565.1 - 0.57 10.3 21.2 0.86 9.8 21.2 1.2 1 0 0 1 1 1 0 C-terminal domain of tail specific protease (DUF3340) DUF2151 PF10221.9 ELR24565.1 - 4.1 5.9 7.3 5.8 5.4 7.3 1.1 1 0 0 1 1 1 0 Cell cycle and development regulator LCD1 PF09798.9 ELR24565.1 - 4.2 5.8 12.3 1.6 7.1 9.9 1.4 2 0 0 2 2 2 0 DNA damage checkpoint protein HATPase_c PF02518.26 ELR24566.1 - 4.7e-27 94.7 0.0 8.6e-27 93.9 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 ELR24566.1 - 6.8e-20 71.3 1.9 1.6e-19 70.1 0.6 2.3 2 1 0 2 2 2 1 Response regulator receiver domain HisKA PF00512.25 ELR24566.1 - 2.7e-18 65.8 0.3 1e-17 63.9 0.3 2.1 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain PAS_3 PF08447.12 ELR24566.1 - 1.2e-12 47.9 2.0 1.6e-08 34.7 0.0 2.9 3 0 0 3 3 3 2 PAS fold GAF_3 PF13492.6 ELR24566.1 - 1.4e-05 25.4 0.0 3.8e-05 24.0 0.0 1.8 2 0 0 2 2 2 1 GAF domain GAF_2 PF13185.6 ELR24566.1 - 1.6e-05 25.3 0.0 0.00018 21.8 0.0 2.5 2 0 0 2 2 2 1 GAF domain GAF PF01590.26 ELR24566.1 - 0.00098 19.8 0.0 0.0024 18.5 0.0 1.7 1 0 0 1 1 1 1 GAF domain PAS PF00989.25 ELR24566.1 - 0.0067 16.4 0.0 0.03 14.3 0.0 2.2 1 0 0 1 1 1 1 PAS fold PAS_9 PF13426.7 ELR24566.1 - 0.037 14.3 0.0 0.27 11.5 0.0 2.4 2 0 0 2 2 2 0 PAS domain FAD_binding_4 PF01565.23 ELR24567.1 - 6.9e-31 106.8 1.9 1.1e-30 106.2 1.9 1.3 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 ELR24568.1 - 4.9e-09 36.1 0.2 9e-09 35.3 0.2 1.4 1 0 0 1 1 1 1 Berberine and berberine like NeA_P2 PF12312.8 ELR24569.1 - 0.098 12.1 2.9 0.19 11.2 2.9 1.4 1 0 0 1 1 1 0 Nepovirus subgroup A polyprotein TPR_12 PF13424.6 ELR24569.1 - 0.21 11.9 1.5 0.68 10.3 1.5 1.9 1 0 0 1 1 1 0 Tetratricopeptide repeat UvrD-helicase PF00580.21 ELR24570.1 - 8.5e-58 196.3 0.0 2.5e-57 194.8 0.0 1.8 2 0 0 2 2 2 1 UvrD/REP helicase N-terminal domain UvrD_C PF13361.6 ELR24570.1 - 2.5e-37 129.1 0.1 1.1e-24 87.4 0.0 2.3 2 0 0 2 2 2 2 UvrD-like helicase C-terminal domain AAA_19 PF13245.6 ELR24570.1 - 5.4e-30 104.7 0.0 1.3e-29 103.4 0.0 1.7 1 0 0 1 1 1 1 AAA domain UvrD_C_2 PF13538.6 ELR24570.1 - 2.7e-13 49.5 0.3 8.9e-06 25.4 0.0 2.9 2 0 0 2 2 2 2 UvrD-like helicase C-terminal domain AAA_30 PF13604.6 ELR24570.1 - 2.3e-08 34.0 0.0 0.00062 19.5 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_11 PF13086.6 ELR24570.1 - 7.2e-07 29.2 0.2 7.2e-07 29.2 0.2 3.4 3 1 0 3 3 3 1 AAA domain Viral_helicase1 PF01443.18 ELR24570.1 - 1.7e-05 24.7 2.4 0.26 11.0 0.5 3.9 3 1 0 3 3 3 2 Viral (Superfamily 1) RNA helicase AAA_12 PF13087.6 ELR24570.1 - 0.0015 18.2 0.0 0.012 15.3 0.0 2.5 3 0 0 3 3 3 1 AAA domain AAA_22 PF13401.6 ELR24570.1 - 0.18 12.1 0.4 15 5.9 0.0 2.9 3 0 0 3 3 3 0 AAA domain Pept_tRNA_hydro PF01195.19 ELR24571.1 - 2.9e-18 66.4 0.0 3.3e-18 66.2 0.0 1.1 1 0 0 1 1 1 1 Peptidyl-tRNA hydrolase DUF543 PF04418.12 ELR24572.1 - 5.5e-11 42.3 1.8 6.8e-11 42.0 1.8 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF543) PQ-loop PF04193.14 ELR24573.1 - 1.8e-36 123.7 14.2 1.7e-20 72.5 2.0 2.6 3 0 0 3 3 3 2 PQ loop repeat RBM1CTR PF08081.11 ELR24574.1 - 0.049 13.7 0.2 0.26 11.4 0.2 2.2 1 0 0 1 1 1 0 RBM1CTR (NUC064) family PH PF00169.29 ELR24575.1 - 2.9e-43 146.7 1.0 1.7e-20 73.5 0.1 2.6 2 0 0 2 2 2 2 PH domain PH_11 PF15413.6 ELR24575.1 - 1.1e-13 51.5 5.3 1.6e-05 25.3 0.0 3.9 2 1 0 2 2 2 2 Pleckstrin homology domain RhoGAP PF00620.27 ELR24575.1 - 4.8e-10 39.5 0.2 2.8e-09 36.9 0.1 2.2 1 1 1 2 2 2 1 RhoGAP domain PH_3 PF14593.6 ELR24575.1 - 1.4e-08 34.7 1.5 0.011 15.8 0.2 3.7 3 2 0 3 3 3 2 PH domain PH_8 PF15409.6 ELR24575.1 - 9.6e-08 32.2 0.7 0.048 13.9 0.0 4.3 4 0 0 4 4 4 2 Pleckstrin homology domain S8_pro-domain PF16470.5 ELR24575.1 - 0.0037 18.0 1.8 0.0078 17.0 0.0 2.5 3 0 0 3 3 3 1 Peptidase S8 pro-domain PH_9 PF15410.6 ELR24575.1 - 0.093 13.1 0.9 40 4.6 0.0 3.8 4 0 0 4 4 4 0 Pleckstrin homology domain PRK PF00485.18 ELR24576.1 - 1.8e-45 155.1 0.0 2.2e-45 154.8 0.0 1.1 1 0 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family CoaE PF01121.20 ELR24576.1 - 4.6e-05 23.2 0.0 0.0048 16.6 0.0 2.1 2 0 0 2 2 2 1 Dephospho-CoA kinase Zeta_toxin PF06414.12 ELR24576.1 - 0.00011 21.6 0.0 0.00031 20.1 0.0 1.6 2 0 0 2 2 2 1 Zeta toxin T2SSE PF00437.20 ELR24576.1 - 0.0028 16.8 0.0 0.005 15.9 0.0 1.3 1 0 0 1 1 1 1 Type II/IV secretion system protein Cytidylate_kin PF02224.18 ELR24576.1 - 0.023 14.4 0.4 3.3 7.4 0.0 2.2 1 1 0 2 2 2 0 Cytidylate kinase AAA_18 PF13238.6 ELR24576.1 - 0.024 15.2 0.5 0.1 13.1 0.5 1.9 1 1 0 1 1 1 0 AAA domain MobB PF03205.14 ELR24576.1 - 0.042 13.7 0.2 0.23 11.3 0.1 2.2 3 0 0 3 3 3 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_17 PF13207.6 ELR24576.1 - 0.051 14.0 0.4 8.2 6.9 0.0 2.3 2 0 0 2 2 2 0 AAA domain cobW PF02492.19 ELR24576.1 - 0.097 12.3 0.0 0.18 11.4 0.0 1.4 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain ABC_tran PF00005.27 ELR24576.1 - 0.11 13.0 0.0 0.18 12.3 0.0 1.6 1 1 0 1 1 1 0 ABC transporter CPT PF07931.12 ELR24576.1 - 0.16 11.8 0.0 0.3 10.9 0.0 1.4 1 0 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein HlyIII PF03006.20 ELR24577.1 - 7.3e-44 150.1 30.4 8.9e-44 149.9 30.4 1.1 1 0 0 1 1 1 1 Haemolysin-III related DUF5399 PF17377.2 ELR24577.1 - 0.015 15.1 0.1 0.036 13.9 0.1 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF5399) ERCC3_RAD25_C PF16203.5 ELR24578.1 - 1.3e-62 211.3 0.0 2.2e-62 210.5 0.0 1.3 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase ResIII PF04851.15 ELR24578.1 - 1.8e-16 60.6 0.0 4.8e-16 59.2 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 ELR24578.1 - 7e-13 48.9 0.1 5.3e-12 46.1 0.0 2.4 2 0 0 2 2 2 1 Helicase conserved C-terminal domain SNF2_N PF00176.23 ELR24578.1 - 1.6e-05 23.8 0.1 2.7e-05 23.1 0.1 1.5 1 0 0 1 1 1 1 SNF2 family N-terminal domain AAA_34 PF13872.6 ELR24578.1 - 0.014 14.3 0.1 0.028 13.3 0.1 1.5 1 0 0 1 1 1 0 P-loop containing NTP hydrolase pore-1 DUF3638 PF12340.8 ELR24578.1 - 0.11 11.8 0.0 0.38 10.0 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3638) TFA2_Winged_2 PF18121.1 ELR24579.1 - 6.3e-06 25.8 0.1 0.0041 16.8 0.1 3.0 2 0 0 2 2 2 2 TFA2 Winged helix domain 2 Helicase_C_3 PF13625.6 ELR24579.1 - 0.062 13.5 0.0 0.22 11.7 0.0 1.9 1 0 0 1 1 1 0 Helicase conserved C-terminal domain TFIIE_alpha PF02002.17 ELR24579.1 - 1.3 8.9 7.0 24 4.9 0.0 4.1 5 0 0 5 5 5 0 TFIIE alpha subunit DNA_photolyase PF00875.18 ELR24580.1 - 0.0073 16.3 0.0 0.032 14.2 0.0 1.8 1 1 1 2 2 2 1 DNA photolyase RNase_PH PF01138.21 ELR24581.1 - 7.7e-18 65.3 0.1 1.6e-15 57.7 0.1 2.3 1 1 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 ELR24581.1 - 2e-08 34.1 0.0 3.7e-08 33.3 0.0 1.4 1 0 0 1 1 1 1 3' exoribonuclease family, domain 2 WD40 PF00400.32 ELR24582.1 - 1.3e-11 44.8 0.6 1.1 10.3 0.0 7.1 7 0 0 7 7 7 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ELR24582.1 - 0.0001 22.5 0.2 4.9 7.5 0.0 4.2 3 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain BBS2_N PF14781.6 ELR24582.1 - 0.019 14.9 0.2 0.44 10.5 0.0 2.7 3 1 0 3 3 3 0 Ciliary BBSome complex subunit 2, N-terminal DPPIV_N PF00930.21 ELR24582.1 - 0.033 13.0 0.1 0.22 10.2 0.0 2.2 2 0 0 2 2 2 0 Dipeptidyl peptidase IV (DPP IV) N-terminal region DAO PF01266.24 ELR24583.1 - 1.7e-51 175.9 0.9 2.3e-51 175.5 0.9 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase Trp_halogenase PF04820.14 ELR24583.1 - 0.025 13.4 0.8 3 6.6 0.5 2.1 2 0 0 2 2 2 0 Tryptophan halogenase SNARE_assoc PF09335.11 ELR24583.1 - 0.053 14.0 0.2 0.11 13.0 0.2 1.4 1 0 0 1 1 1 0 SNARE associated Golgi protein Pyr_redox_2 PF07992.14 ELR24583.1 - 0.081 12.1 0.1 1.4 8.1 0.0 2.1 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Vps5 PF09325.10 ELR24584.1 - 1.6e-37 129.4 13.8 2.5e-37 128.7 13.8 1.3 1 0 0 1 1 1 1 Vps5 C terminal like PX PF00787.24 ELR24584.1 - 1.3e-28 99.2 0.1 2.8e-28 98.1 0.1 1.5 1 0 0 1 1 1 1 PX domain DUF3960 PF13142.6 ELR24584.1 - 0.047 13.8 0.1 0.39 10.9 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3960) L51_S25_CI-B8 PF05047.16 ELR24585.1 - 0.081 12.9 1.5 0.15 12.0 1.5 1.4 1 0 0 1 1 1 0 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain HrpJ PF07201.11 ELR24586.1 - 0.067 13.5 0.1 0.067 13.5 0.1 1.1 1 0 0 1 1 1 0 HrpJ-like domain DNA_ligase_A_M PF01068.21 ELR24587.1 - 3.1e-64 216.4 0.0 3.1e-64 216.4 0.0 1.7 2 0 0 2 2 2 1 ATP dependent DNA ligase domain DNA_ligase_A_N PF04675.14 ELR24587.1 - 1.6e-45 155.5 0.0 2.7e-45 154.8 0.0 1.4 1 0 0 1 1 1 1 DNA ligase N terminus DNA_ligase_A_C PF04679.15 ELR24587.1 - 1.1e-25 90.0 0.0 5.1e-25 88.0 0.0 2.2 2 0 0 2 2 2 1 ATP dependent DNA ligase C terminal region RNA_ligase PF09414.10 ELR24587.1 - 7.7e-07 29.6 0.1 1.6e-06 28.5 0.1 1.6 1 0 0 1 1 1 1 RNA ligase DNA_ligase_OB_2 PF14743.6 ELR24587.1 - 0.0014 18.7 0.1 0.16 12.0 0.0 2.9 2 0 0 2 2 2 1 DNA ligase OB-like domain mRNA_cap_enzyme PF01331.19 ELR24587.1 - 0.0014 18.5 0.1 0.15 11.8 0.1 2.3 1 1 0 1 1 1 1 mRNA capping enzyme, catalytic domain DsbC PF11412.8 ELR24587.1 - 0.1 12.6 0.5 1.1 9.3 0.0 2.4 2 0 0 2 2 2 0 Disulphide bond corrector protein DsbC His_kinase PF06580.13 ELR24587.1 - 0.17 12.2 0.0 1.1 9.6 0.0 2.4 2 0 0 2 2 2 0 Histidine kinase Pes-10 PF07149.11 ELR24587.1 - 1.1 8.3 6.4 1.7 7.6 6.4 1.3 1 0 0 1 1 1 0 Pes-10 T6SS_HCP PF05638.12 ELR24588.1 - 0.00043 20.7 0.0 0.33 11.4 0.0 2.6 3 0 0 3 3 3 2 Type VI secretion system effector, Hcp AAA PF00004.29 ELR24590.1 - 5.9e-31 107.6 0.0 9.3e-31 107.0 0.0 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.6 ELR24590.1 - 7.1e-06 26.6 0.0 0.00011 22.8 0.0 2.6 2 1 1 3 3 3 1 AAA domain AAA_22 PF13401.6 ELR24590.1 - 2.2e-05 24.7 0.1 8.9e-05 22.8 0.1 2.0 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 ELR24590.1 - 4.2e-05 24.0 0.1 0.00024 21.5 0.0 2.1 2 1 0 2 2 2 1 AAA ATPase domain AAA_2 PF07724.14 ELR24590.1 - 9.2e-05 22.6 0.0 0.00026 21.2 0.0 1.7 1 1 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_24 PF13479.6 ELR24590.1 - 0.00028 20.7 0.0 0.00048 19.9 0.0 1.4 1 0 0 1 1 1 1 AAA domain RuvB_N PF05496.12 ELR24590.1 - 0.0012 18.6 0.1 0.013 15.2 0.0 2.2 1 1 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_33 PF13671.6 ELR24590.1 - 0.0032 17.6 0.0 0.0089 16.2 0.0 1.9 1 1 0 1 1 1 1 AAA domain AAA_5 PF07728.14 ELR24590.1 - 0.0035 17.4 0.0 0.0098 15.9 0.0 1.9 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) IstB_IS21 PF01695.17 ELR24590.1 - 0.0037 17.0 0.0 0.0088 15.8 0.0 1.7 1 0 0 1 1 1 1 IstB-like ATP binding protein Sigma54_activat PF00158.26 ELR24590.1 - 0.0038 17.0 0.0 0.0068 16.1 0.0 1.3 1 0 0 1 1 1 1 Sigma-54 interaction domain AAA_25 PF13481.6 ELR24590.1 - 0.004 16.8 0.1 0.51 9.9 0.0 2.3 1 1 1 2 2 2 1 AAA domain RNA_helicase PF00910.22 ELR24590.1 - 0.0042 17.4 0.0 0.011 16.1 0.0 1.7 1 0 0 1 1 1 1 RNA helicase AAA_7 PF12775.7 ELR24590.1 - 0.0051 16.3 0.0 0.0092 15.5 0.0 1.3 1 0 0 1 1 1 1 P-loop containing dynein motor region Cytidylate_kin2 PF13189.6 ELR24590.1 - 0.0068 16.6 0.0 5.3 7.1 0.0 2.3 2 0 0 2 2 2 2 Cytidylate kinase-like family ATPase_2 PF01637.18 ELR24590.1 - 0.0091 15.9 0.1 2.4 8.0 0.0 2.3 1 1 1 2 2 2 1 ATPase domain predominantly from Archaea DUF815 PF05673.13 ELR24590.1 - 0.015 14.5 0.0 0.19 10.9 0.0 2.3 1 1 0 1 1 1 0 Protein of unknown function (DUF815) AAA_28 PF13521.6 ELR24590.1 - 0.018 15.3 0.0 0.047 13.9 0.0 1.7 1 0 0 1 1 1 0 AAA domain Mg_chelatase PF01078.21 ELR24590.1 - 0.019 14.3 0.0 0.087 12.2 0.0 1.9 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_11 PF13086.6 ELR24590.1 - 0.021 14.6 0.1 0.074 12.8 0.1 1.9 1 1 0 1 1 1 0 AAA domain AAA_13 PF13166.6 ELR24590.1 - 0.024 13.3 0.0 0.035 12.8 0.0 1.2 1 0 0 1 1 1 0 AAA domain Parvo_NS1 PF01057.17 ELR24590.1 - 0.029 13.5 0.0 0.045 12.8 0.0 1.2 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 AAA_14 PF13173.6 ELR24590.1 - 0.049 13.7 0.0 0.096 12.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain PhoH PF02562.16 ELR24590.1 - 0.049 13.1 0.0 0.29 10.6 0.0 2.1 2 0 0 2 2 2 0 PhoH-like protein Cytidylate_kin PF02224.18 ELR24590.1 - 0.059 13.1 0.4 0.18 11.5 0.0 1.8 2 1 0 2 2 1 0 Cytidylate kinase TsaE PF02367.17 ELR24590.1 - 0.06 13.4 0.0 0.12 12.4 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE NACHT PF05729.12 ELR24590.1 - 0.079 12.9 0.0 0.22 11.4 0.0 1.7 1 1 0 1 1 1 0 NACHT domain Rad17 PF03215.15 ELR24590.1 - 0.088 12.7 0.0 0.35 10.8 0.0 1.8 1 1 1 2 2 2 0 Rad17 P-loop domain ArsA_ATPase PF02374.15 ELR24590.1 - 0.13 11.4 0.1 0.44 9.7 0.0 1.7 1 1 1 2 2 2 0 Anion-transporting ATPase AAA_19 PF13245.6 ELR24590.1 - 0.14 12.4 0.3 1.2 9.5 0.0 2.5 2 1 0 3 3 2 0 AAA domain SKI PF01202.22 ELR24590.1 - 0.16 12.1 0.0 0.33 11.1 0.0 1.5 1 0 0 1 1 1 0 Shikimate kinase DUF2075 PF09848.9 ELR24590.1 - 0.21 10.8 0.0 0.38 9.9 0.0 1.5 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) GFO_IDH_MocA PF01408.22 ELR24592.1 - 3.9e-07 30.9 0.0 4.2e-06 27.6 0.0 2.3 2 1 0 2 2 2 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.17 ELR24592.1 - 0.00036 20.5 0.0 0.00065 19.7 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase family, C-terminal alpha/beta domain DIOX_N PF14226.6 ELR24593.1 - 8.9e-31 107.1 0.0 1.4e-30 106.4 0.0 1.3 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 ELR24593.1 - 1.6e-25 89.5 0.0 2.8e-25 88.7 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Pex2_Pex12 PF04757.14 ELR24594.1 - 1.2e-40 139.5 6.6 1.7e-40 139.0 6.6 1.1 1 0 0 1 1 1 1 Pex2 / Pex12 amino terminal region zf-C3HC4_3 PF13920.6 ELR24594.1 - 6.7e-07 29.1 6.4 1e-06 28.5 6.4 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 ELR24594.1 - 1.1e-06 28.4 6.3 1.7e-06 27.8 6.3 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 ELR24594.1 - 1.2e-05 25.5 5.6 1.8e-05 25.0 5.6 1.3 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.6 ELR24594.1 - 1.6e-05 24.8 7.1 2.4e-05 24.2 7.1 1.3 1 0 0 1 1 1 1 zinc-RING finger domain Prok-RING_4 PF14447.6 ELR24594.1 - 1.7e-05 24.6 7.2 2.6e-05 24.0 7.2 1.3 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_2 PF13923.6 ELR24594.1 - 3.4e-05 23.6 7.0 5.9e-05 22.8 7.0 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 ELR24594.1 - 0.0027 17.7 7.4 0.0058 16.6 7.4 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-rbx1 PF12678.7 ELR24594.1 - 0.0047 17.2 3.1 0.008 16.5 3.1 1.3 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_4 PF15227.6 ELR24594.1 - 0.012 15.7 8.8 0.022 14.9 8.8 1.5 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-RING_10 PF16685.5 ELR24594.1 - 0.39 10.9 5.2 0.74 10.0 5.2 1.4 1 0 0 1 1 1 0 zinc RING finger of MSL2 DZR PF12773.7 ELR24594.1 - 0.6 10.2 6.4 1.7 8.7 6.4 1.7 1 1 0 1 1 1 0 Double zinc ribbon zinc-ribbons_6 PF07191.12 ELR24594.1 - 0.77 9.8 4.3 2.7 8.0 4.7 1.6 1 1 1 2 2 2 0 zinc-ribbons zf-RING_4 PF14570.6 ELR24594.1 - 2.9 7.7 7.4 4.8 7.1 7.4 1.4 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain GGACT PF06094.12 ELR24595.1 - 9e-10 39.2 0.1 1.2e-09 38.8 0.1 1.2 1 0 0 1 1 1 1 Gamma-glutamyl cyclotransferase, AIG2-like UBA_4 PF14555.6 ELR24596.1 - 0.00056 19.7 0.1 0.0011 18.8 0.1 1.4 1 0 0 1 1 1 1 UBA-like domain zf-RING_2 PF13639.6 ELR24597.1 - 1.8e-10 41.0 9.6 4.3e-05 23.8 1.6 2.3 2 0 0 2 2 2 2 Ring finger domain zf-RING_11 PF17123.5 ELR24597.1 - 5.6e-07 29.2 0.9 5.6e-07 29.2 0.9 1.9 2 0 0 2 2 2 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 ELR24597.1 - 6.1e-06 26.0 8.0 0.0029 17.4 0.7 2.3 2 0 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 ELR24597.1 - 0.0007 19.4 9.0 0.12 12.3 1.9 2.3 2 0 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 ELR24597.1 - 0.001 18.9 7.3 0.0061 16.4 0.6 2.3 2 0 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 ELR24597.1 - 0.0014 18.9 1.9 0.0014 18.9 1.9 2.6 2 1 0 2 2 2 1 RING-H2 zinc finger domain zf-RING_5 PF14634.6 ELR24597.1 - 0.014 15.3 6.2 0.12 12.4 6.2 2.1 1 1 0 1 1 1 0 zinc-RING finger domain Prok-RING_4 PF14447.6 ELR24597.1 - 0.015 15.2 0.5 0.015 15.2 0.5 2.2 2 1 1 3 3 3 0 Prokaryotic RING finger family 4 zf-RING_UBOX PF13445.6 ELR24597.1 - 0.055 13.5 2.1 0.055 13.5 2.1 2.5 2 1 1 3 3 3 0 RING-type zinc-finger Rod-binding PF10135.9 ELR24597.1 - 0.11 13.1 1.2 0.33 11.6 0.4 2.0 2 0 0 2 2 2 0 Rod binding protein zf-RING_4 PF14570.6 ELR24597.1 - 0.23 11.3 8.4 2.6 7.9 0.4 2.4 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain RINGv PF12906.7 ELR24597.1 - 2.7 8.2 7.8 2 8.6 1.3 2.4 2 0 0 2 2 2 0 RING-variant domain BAR_3 PF16746.5 ELR24598.1 - 1.6e-17 64.0 7.4 2.6e-17 63.3 7.4 1.3 1 0 0 1 1 1 1 BAR domain of APPL family BAR PF03114.18 ELR24598.1 - 6.4e-08 32.5 8.6 1.1e-07 31.8 8.6 1.3 1 0 0 1 1 1 1 BAR domain IMD PF08397.11 ELR24598.1 - 0.0024 17.3 7.0 0.0024 17.3 7.0 1.9 2 0 0 2 2 2 1 IRSp53/MIM homology domain SCAB_CC PF16712.5 ELR24598.1 - 0.018 14.8 6.8 0.26 11.1 1.1 2.4 2 0 0 2 2 2 0 Coiled-coil regions of plant-specific actin-binding protein FlgN PF05130.12 ELR24598.1 - 0.17 12.4 5.1 1.5 9.3 1.3 2.9 2 1 0 2 2 2 0 FlgN protein UPF0242 PF06785.11 ELR24598.1 - 3.2 7.8 8.2 5.4 7.1 1.6 2.4 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus FAD_binding_1 PF00667.20 ELR24599.1 - 9.9e-29 100.5 0.0 1.9e-28 99.6 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain NAD_binding_1 PF00175.21 ELR24599.1 - 7.7e-10 39.4 0.0 1.5e-09 38.4 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain Flavodoxin_1 PF00258.25 ELR24599.1 - 1.1e-08 35.4 0.1 6.5e-08 32.9 0.0 2.1 2 0 0 2 2 2 1 Flavodoxin RasGEF_N PF00618.20 ELR24599.1 - 0.00019 21.6 0.0 0.00045 20.4 0.0 1.6 1 0 0 1 1 1 1 RasGEF N-terminal motif RasGEF PF00617.19 ELR24600.1 - 7.3e-41 140.3 0.0 2e-40 138.9 0.0 1.8 1 0 0 1 1 1 1 RasGEF domain Ank PF00023.30 ELR24600.1 - 7e-16 57.9 2.8 2.3e-07 31.0 0.2 3.2 3 0 0 3 3 3 2 Ankyrin repeat Ank_4 PF13637.6 ELR24600.1 - 9.5e-16 58.0 4.7 5e-07 30.1 0.2 3.3 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 ELR24600.1 - 4.3e-15 56.1 0.7 1.7e-14 54.1 0.4 2.2 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 ELR24600.1 - 2.6e-14 53.1 1.3 2.1e-09 37.5 0.0 3.2 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 ELR24600.1 - 3e-12 45.6 1.7 2.5e-06 27.4 0.0 4.0 4 0 0 4 4 4 2 Ankyrin repeat Hemerythrin PF01814.23 ELR24600.1 - 2.1e-05 25.1 1.0 0.0019 18.8 1.0 2.8 1 1 0 1 1 1 1 Hemerythrin HHE cation binding domain TMEM70 PF06979.12 ELR24601.1 - 1.1e-15 58.2 0.1 2.5e-15 57.0 0.1 1.6 1 1 0 1 1 1 1 Assembly, mitochondrial proton-transport ATP synth complex PTR2 PF00854.21 ELR24602.1 - 2.6e-98 329.4 8.8 4e-98 328.8 8.8 1.2 1 0 0 1 1 1 1 POT family CoA_binding_3 PF13727.6 ELR24602.1 - 0.1 12.6 1.0 0.23 11.4 1.0 1.6 1 0 0 1 1 1 0 CoA-binding domain TMEM138 PF14935.6 ELR24602.1 - 0.31 11.7 0.1 0.31 11.7 0.1 2.8 3 1 0 3 3 3 0 Transmembrane protein 138 LRR_8 PF13855.6 ELR24603.1 - 1.3e-15 56.8 10.5 1.2e-08 34.5 3.3 3.3 1 1 2 3 3 3 3 Leucine rich repeat LRR_4 PF12799.7 ELR24603.1 - 8.3e-12 45.1 9.9 6.6e-07 29.6 1.9 4.2 2 2 2 4 4 4 2 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 ELR24603.1 - 1.6e-08 34.2 3.5 2.9e-05 23.6 0.1 2.7 1 1 2 3 3 3 3 Leucine-rich repeat zf-MYND PF01753.18 ELR24603.1 - 0.15 12.2 0.3 1.1 9.4 0.0 2.5 3 1 0 3 3 3 0 MYND finger DTHCT PF08070.11 ELR24603.1 - 1 10.1 5.6 0.52 11.1 3.3 1.7 2 0 0 2 2 2 0 DTHCT (NUC029) region LRR_1 PF00560.33 ELR24603.1 - 2.9 8.8 7.2 80 4.4 0.1 4.5 4 0 0 4 4 4 0 Leucine Rich Repeat CDC45 PF02724.14 ELR24603.1 - 4.5 5.5 5.6 5.5 5.2 5.6 1.1 1 0 0 1 1 1 0 CDC45-like protein F-box-like PF12937.7 ELR24604.1 - 3.3e-07 30.1 1.4 7.1e-07 29.0 1.4 1.6 1 0 0 1 1 1 1 F-box-like F-box_4 PF15966.5 ELR24604.1 - 9.2e-05 22.3 0.2 0.00016 21.5 0.2 1.3 1 0 0 1 1 1 1 F-box F-box PF00646.33 ELR24604.1 - 0.001 18.9 2.8 0.001 18.9 2.8 1.8 2 0 0 2 2 2 1 F-box domain Beach PF02138.18 ELR24605.1 - 1.2e-36 126.5 0.0 2e-36 125.8 0.0 1.3 1 0 0 1 1 1 1 Beige/BEACH domain Pkinase PF00069.25 ELR24605.1 - 1.5e-15 57.2 0.0 4.7e-07 29.4 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain WD40 PF00400.32 ELR24605.1 - 4.1e-09 36.9 7.8 0.00082 20.1 1.7 5.4 5 1 0 5 5 5 2 WD domain, G-beta repeat Antifungal_prot PF11402.8 ELR24605.1 - 0.15 12.3 0.4 0.3 11.3 0.4 1.4 1 0 0 1 1 1 0 Antifungal protein HATPase_c PF02518.26 ELR24606.1 - 1e-26 93.6 0.0 2e-26 92.7 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 ELR24606.1 - 2.2e-21 76.1 0.0 4.7e-21 75.0 0.0 1.6 1 0 0 1 1 1 1 Response regulator receiver domain HisKA PF00512.25 ELR24606.1 - 1.5e-16 60.1 0.2 3.3e-16 59.1 0.2 1.6 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain HATPase_c_2 PF13581.6 ELR24606.1 - 0.018 15.0 0.0 0.036 14.0 0.0 1.5 1 0 0 1 1 1 0 Histidine kinase-like ATPase domain HATPase_c_3 PF13589.6 ELR24606.1 - 0.052 13.4 0.0 0.12 12.2 0.0 1.6 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Glycos_transf_4 PF00953.21 ELR24607.1 - 3.8e-36 124.5 14.7 3.8e-36 124.5 14.7 2.9 3 0 0 3 3 3 1 Glycosyl transferase family 4 DUF2009 PF09418.10 ELR24608.1 - 2.2e-199 663.2 0.9 1.7e-198 660.3 0.9 1.9 1 1 0 1 1 1 1 Protein of unknown function (DUF2009) zf-B_box PF00643.24 ELR24608.1 - 0.0012 18.9 3.6 0.0026 17.9 3.6 1.6 1 0 0 1 1 1 1 B-box zinc finger zf-C3HC4_3 PF13920.6 ELR24608.1 - 0.0031 17.3 3.6 0.0078 16.1 3.6 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) CEBP_ZZ PF16366.5 ELR24608.1 - 0.0047 17.1 1.7 0.013 15.7 1.6 1.7 2 0 0 2 2 2 1 Cytoplasmic polyadenylation element-binding protein ZZ domain DUF4236 PF14020.6 ELR24608.1 - 0.02 15.5 0.0 4.7 7.9 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF4236) Glyco_hydro_20b PF02838.15 ELR24608.1 - 0.12 13.1 0.3 0.31 11.8 0.1 1.9 2 1 0 2 2 2 0 Glycosyl hydrolase family 20, domain 2 DUF2740 PF10872.8 ELR24608.1 - 0.14 12.1 0.1 0.31 10.9 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2740) Prok-RING_4 PF14447.6 ELR24608.1 - 0.61 10.0 6.1 1.2 9.1 6.1 1.4 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 GCIP PF13324.6 ELR24609.1 - 4.2e-34 118.3 5.4 5.7e-34 117.9 5.4 1.1 1 0 0 1 1 1 1 Grap2 and cyclin-D-interacting Nop16 PF09420.10 ELR24609.1 - 0.0011 19.0 6.2 0.0024 17.9 6.2 1.6 1 0 0 1 1 1 1 Ribosome biogenesis protein Nop16 Sigma70_ner PF04546.13 ELR24609.1 - 0.0041 17.0 13.9 0.039 13.8 5.4 2.5 2 0 0 2 2 2 2 Sigma-70, non-essential region Nha1_C PF08619.10 ELR24609.1 - 0.015 14.5 9.5 0.022 14.0 9.5 1.1 1 0 0 1 1 1 0 Alkali metal cation/H+ antiporter Nha1 C terminus DUF913 PF06025.12 ELR24609.1 - 0.017 14.1 2.1 0.028 13.4 2.1 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) BUD22 PF09073.10 ELR24609.1 - 0.031 13.6 24.0 0.041 13.2 23.5 1.4 1 1 0 1 1 1 0 BUD22 I_LWEQ PF01608.17 ELR24609.1 - 0.066 13.5 9.5 16 5.7 1.0 3.7 2 1 0 3 3 3 0 I/LWEQ domain CDC27 PF09507.10 ELR24609.1 - 0.15 11.5 20.4 0.045 13.1 17.5 1.6 2 0 0 2 2 2 0 DNA polymerase subunit Cdc27 SDA1 PF05285.12 ELR24609.1 - 0.18 11.2 21.6 0.28 10.6 21.6 1.2 1 0 0 1 1 1 0 SDA1 SAPS PF04499.15 ELR24609.1 - 0.18 10.5 3.6 0.24 10.1 3.6 1.2 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Cwf_Cwc_15 PF04889.12 ELR24609.1 - 0.51 10.0 27.4 0.028 14.1 12.8 2.2 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein Presenilin PF01080.17 ELR24609.1 - 0.88 8.3 2.8 1.4 7.6 2.8 1.3 1 0 0 1 1 1 0 Presenilin CobT PF06213.12 ELR24609.1 - 0.89 8.9 21.4 0.16 11.3 12.8 2.4 2 0 0 2 2 2 0 Cobalamin biosynthesis protein CobT DUF4065 PF13274.6 ELR24609.1 - 0.96 10.4 7.6 3 8.8 1.1 2.6 3 0 0 3 3 2 0 Protein of unknown function (DUF4065) RXT2_N PF08595.11 ELR24609.1 - 1.4 8.9 18.4 0.3 11.1 8.7 2.3 2 0 0 2 2 2 0 RXT2-like, N-terminal FYDLN_acid PF09538.10 ELR24609.1 - 1.9 9.2 28.0 0.85 10.3 17.3 2.4 2 0 0 2 2 2 0 Protein of unknown function (FYDLN_acid) RNA_pol_3_Rpc31 PF11705.8 ELR24609.1 - 2.6 8.2 30.1 0.056 13.7 15.5 2.3 2 0 0 2 2 2 0 DNA-directed RNA polymerase III subunit Rpc31 Myc_N PF01056.18 ELR24609.1 - 3.7 7.3 10.3 0.25 11.2 2.4 2.2 2 0 0 2 2 2 0 Myc amino-terminal region FAM176 PF14851.6 ELR24609.1 - 4.2 7.0 19.2 6.6 6.4 10.6 2.4 2 0 0 2 2 2 0 FAM176 family Pox_Ag35 PF03286.14 ELR24609.1 - 4.8 6.9 21.8 0.2 11.5 9.3 2.5 2 0 0 2 2 2 0 Pox virus Ag35 surface protein Cytomega_UL84 PF06284.11 ELR24609.1 - 5.8 5.3 8.5 10 4.4 8.5 1.3 1 0 0 1 1 1 0 Cytomegalovirus UL84 protein DUF4820 PF16091.5 ELR24609.1 - 6.7 6.0 15.5 0.12 11.8 3.9 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4820) Vfa1 PF08432.10 ELR24609.1 - 6.8 7.0 18.1 0.69 10.2 9.0 2.2 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 Afi1 PF07792.12 ELR24609.1 - 9.6 6.7 15.6 12 6.4 9.2 2.2 2 0 0 2 2 2 0 Docking domain of Afi1 for Arf3 in vesicle trafficking OAD_gamma PF04277.13 ELR24609.1 - 10 6.8 6.6 14 6.4 4.1 2.4 2 0 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain D123 PF07065.14 ELR24610.1 - 3.3e-16 59.3 0.2 3.3e-16 59.3 0.2 3.0 2 1 1 3 3 3 2 D123 Med19 PF10278.9 ELR24610.1 - 0.032 14.2 12.2 0.052 13.5 12.2 1.4 1 0 0 1 1 1 0 Mediator of RNA pol II transcription subunit 19 R2K_2 PF18299.1 ELR24610.1 - 0.064 13.1 0.3 0.16 11.8 0.3 1.7 1 1 0 1 1 1 0 ATP-grasp domain, R2K clade family 2 THOC2_N PF16134.5 ELR24610.1 - 0.15 10.6 12.9 0.21 10.2 12.9 1.1 1 0 0 1 1 1 0 THO complex subunit 2 N-terminus RNA_pol_Rpc4 PF05132.14 ELR24610.1 - 3.1 8.2 10.5 1.3 9.5 8.1 1.6 2 0 0 2 2 2 0 RNA polymerase III RPC4 AP3D1 PF06375.11 ELR24610.1 - 5.3 7.2 18.3 9.3 6.5 18.3 1.4 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 OATP PF03137.20 ELR24610.1 - 5.4 5.2 4.5 7.3 4.8 4.5 1.1 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family MPP6 PF10175.9 ELR24611.1 - 0.19 12.3 2.7 0.23 11.9 2.6 1.4 1 1 0 1 1 1 0 M-phase phosphoprotein 6 F-box-like PF12937.7 ELR24612.1 - 4.9e-08 32.8 1.5 1.1e-07 31.6 1.5 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ELR24612.1 - 0.0021 17.9 0.2 0.0042 16.9 0.2 1.5 1 0 0 1 1 1 1 F-box domain KRBA1 PF15287.6 ELR24612.1 - 0.1 12.3 0.0 0.33 10.7 0.0 1.9 1 0 0 1 1 1 0 KRBA1 family repeat GET2 PF08690.10 ELR24612.1 - 0.19 11.4 1.0 0.3 10.7 1.0 1.2 1 0 0 1 1 1 0 GET complex subunit GET2 DNA_pol_phi PF04931.13 ELR24612.1 - 4.1 5.4 11.6 7 4.6 11.6 1.3 1 0 0 1 1 1 0 DNA polymerase phi CDC45 PF02724.14 ELR24612.1 - 4.3 5.5 7.5 6.7 4.9 7.5 1.2 1 0 0 1 1 1 0 CDC45-like protein APH PF01636.23 ELR24613.1 - 1.2e-11 45.0 7.3 6.3e-10 39.4 7.3 2.2 1 1 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.14 ELR24613.1 - 0.0023 17.3 0.0 0.02 14.3 0.0 2.0 2 1 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family TetR_C_11 PF16859.5 ELR24613.1 - 0.088 13.1 0.5 0.088 13.1 0.5 2.5 4 0 0 4 4 4 0 Tetracyclin repressor-like, C-terminal domain Seadorna_VP7 PF07387.11 ELR24613.1 - 0.17 10.9 0.0 0.25 10.4 0.0 1.1 1 0 0 1 1 1 0 Seadornavirus VP7 Ras PF00071.22 ELR24614.1 - 3.3e-34 117.9 0.0 4.7e-34 117.3 0.0 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR24614.1 - 1.1e-17 64.4 0.0 1.8e-17 63.6 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 ELR24614.1 - 0.034 14.2 0.0 0.061 13.4 0.0 1.5 1 0 0 1 1 1 0 50S ribosome-binding GTPase F-box-like PF12937.7 ELR24614.1 - 0.04 13.8 0.0 0.079 12.9 0.0 1.5 1 0 0 1 1 1 0 F-box-like RsgA_GTPase PF03193.16 ELR24614.1 - 0.14 12.1 0.0 1.7 8.5 0.0 2.2 2 0 0 2 2 2 0 RsgA GTPase Penicil_amidase PF01804.18 ELR24615.1 - 1.1e-91 308.9 13.9 1.4e-91 308.5 13.9 1.1 1 0 0 1 1 1 1 Penicillin amidase DIM PF08194.12 ELR24617.1 - 0.091 13.0 0.9 0.19 12.0 0.9 1.5 1 0 0 1 1 1 0 DIM protein SOCS_box PF07525.16 ELR24620.1 - 0.012 15.9 0.1 0.031 14.6 0.1 1.7 1 0 0 1 1 1 0 SOCS box RRM_1 PF00076.22 ELR24621.1 - 1.1e-29 102.1 1.7 4.7e-18 64.8 0.0 3.3 2 1 1 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 ELR24621.1 - 1.6e-07 31.3 0.1 0.00049 20.2 0.1 2.7 2 1 0 2 2 2 2 RNA recognition motif Presenilin PF01080.17 ELR24621.1 - 0.0058 15.5 6.6 0.0089 14.8 6.6 1.3 1 0 0 1 1 1 1 Presenilin RRM_occluded PF16842.5 ELR24621.1 - 0.017 14.9 0.0 6.8 6.6 0.0 2.9 2 1 0 2 2 2 0 Occluded RNA-recognition motif GEMIN8 PF15348.6 ELR24621.1 - 0.031 14.6 7.7 0.054 13.8 7.7 1.3 1 0 0 1 1 1 0 Gemini of Cajal bodies-associated protein 8 FAM60A PF15396.6 ELR24621.1 - 0.056 13.4 8.4 0.093 12.7 8.4 1.4 1 0 0 1 1 1 0 Protein Family FAM60A Raftlin PF15250.6 ELR24621.1 - 0.068 11.9 5.4 0.11 11.2 5.4 1.3 1 0 0 1 1 1 0 Raftlin PPP4R2 PF09184.11 ELR24621.1 - 0.084 12.5 21.4 0.12 11.9 21.4 1.2 1 0 0 1 1 1 0 PPP4R2 Zip PF02535.22 ELR24621.1 - 0.19 10.9 4.9 0.25 10.5 4.9 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter DUF4746 PF15928.5 ELR24621.1 - 0.29 10.5 17.6 0.42 10.0 17.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) SAGA-Tad1 PF12767.7 ELR24621.1 - 0.45 10.2 7.6 0.75 9.5 7.6 1.3 1 0 0 1 1 1 0 Transcriptional regulator of RNA polII, SAGA, subunit Spore_coat_CotO PF14153.6 ELR24621.1 - 1.5 8.7 19.3 2.6 7.9 19.3 1.4 1 0 0 1 1 1 0 Spore coat protein CotO DUF2151 PF10221.9 ELR24621.1 - 1.7 7.1 9.9 2.3 6.7 9.9 1.1 1 0 0 1 1 1 0 Cell cycle and development regulator CDC27 PF09507.10 ELR24621.1 - 2.5 7.4 32.0 4.4 6.6 32.0 1.4 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Nop14 PF04147.12 ELR24621.1 - 3.3 5.8 26.7 4.6 5.3 26.7 1.1 1 0 0 1 1 1 0 Nop14-like family NPR3 PF03666.13 ELR24621.1 - 4.2 6.1 19.0 6.4 5.4 19.0 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 DUF913 PF06025.12 ELR24621.1 - 4.2 6.2 8.3 6.6 5.6 8.3 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) SAPS PF04499.15 ELR24621.1 - 4.6 5.9 11.6 6 5.5 11.6 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Hid1 PF12722.7 ELR24621.1 - 6.8 4.7 8.3 8.8 4.3 8.3 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Hamartin PF04388.12 ELR24621.1 - 7.9 5.0 12.2 10 4.6 12.2 1.1 1 0 0 1 1 1 0 Hamartin protein RR_TM4-6 PF06459.12 ELR24621.1 - 9 6.0 18.0 18 5.0 18.0 1.5 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 RIC1 PF07064.13 ELR24622.1 - 5.2e-33 114.5 1.1 7.7e-32 110.7 0.9 2.4 2 0 0 2 2 2 1 RIC1 ANAPC4_WD40 PF12894.7 ELR24622.1 - 1.9e-05 24.9 0.0 0.16 12.2 0.0 3.8 3 0 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain GRAM PF02893.20 ELR24623.1 - 7e-09 35.6 0.0 1.3e-08 34.7 0.0 1.5 1 0 0 1 1 1 1 GRAM domain RasGAP_C PF03836.15 ELR24623.1 - 0.0021 18.2 2.3 0.0021 18.2 2.3 2.2 2 0 0 2 2 2 1 RasGAP C-terminus ZapB PF06005.12 ELR24623.1 - 0.034 14.6 20.8 0.034 14.6 8.8 2.7 1 1 0 2 2 2 0 Cell division protein ZapB DUF724 PF05266.14 ELR24623.1 - 0.09 12.6 9.8 0.15 11.9 9.8 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF724) Mating_N PF12731.7 ELR24623.1 - 0.13 12.4 3.5 10 6.3 0.1 2.5 1 1 1 2 2 2 0 Mating-type protein beta 1 FapA PF03961.13 ELR24623.1 - 0.21 10.2 8.9 0.28 9.7 8.9 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A T3SchapCesA PF11439.8 ELR24623.1 - 0.26 11.4 3.4 0.81 9.9 1.9 2.1 1 1 1 2 2 2 0 Type III secretion system filament chaperone CesA JIP_LZII PF16471.5 ELR24623.1 - 1.1 9.5 13.2 1.4 9.2 4.2 2.9 2 1 0 2 2 2 0 JNK-interacting protein leucine zipper II Csm1_N PF18504.1 ELR24623.1 - 1.3 9.5 14.8 0.098 13.0 5.9 2.5 2 0 0 2 2 2 0 Csm1 N-terminal domain YabA PF06156.13 ELR24623.1 - 1.6 9.4 14.5 0.72 10.5 7.4 2.3 1 1 1 2 2 2 0 Initiation control protein YabA GDPD PF03009.17 ELR24624.1 - 4e-27 95.6 0.0 2.1e-23 83.4 0.0 2.2 2 0 0 2 2 2 2 Glycerophosphoryl diester phosphodiesterase family PIP5K PF01504.18 ELR24625.1 - 2.7e-64 217.0 0.6 2.7e-64 217.0 0.6 2.5 3 0 0 3 3 3 1 Phosphatidylinositol-4-phosphate 5-Kinase AP3D1 PF06375.11 ELR24625.1 - 0.014 15.7 5.9 0.014 15.7 5.9 5.7 4 2 0 5 5 5 0 AP-3 complex subunit delta-1 Rieske PF00355.26 ELR24626.1 - 1.3e-08 34.6 0.1 0.0004 20.3 0.0 2.3 2 0 0 2 2 2 2 Rieske [2Fe-2S] domain Rieske_2 PF13806.6 ELR24626.1 - 9.9e-07 28.6 0.0 0.00044 20.2 0.0 2.5 3 0 0 3 3 3 2 Rieske-like [2Fe-2S] domain DNA_pol_phi PF04931.13 ELR24626.1 - 3.3 5.7 3.8 4.4 5.3 3.8 1.3 1 0 0 1 1 1 0 DNA polymerase phi Tetraspanin PF00335.20 ELR24627.1 - 0.42 10.3 6.4 2.9 7.6 7.1 1.7 2 0 0 2 2 2 0 Tetraspanin family Neurensin PF14927.6 ELR24627.1 - 2.1 8.0 8.3 21 4.8 0.8 3.3 3 1 0 3 3 3 0 Neurensin DAGK_acc PF00609.19 ELR24628.1 - 4.2e-49 166.9 0.0 6.6e-49 166.3 0.0 1.3 1 0 0 1 1 1 1 Diacylglycerol kinase accessory domain DAGK_cat PF00781.24 ELR24628.1 - 3.4e-21 75.2 0.0 6.3e-21 74.3 0.0 1.4 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain NAD_kinase PF01513.21 ELR24628.1 - 0.0072 15.6 0.0 0.012 14.9 0.0 1.3 1 0 0 1 1 1 1 ATP-NAD kinase PBP1_TM PF14812.6 ELR24628.1 - 0.36 11.2 2.9 0.72 10.3 2.9 1.5 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Hexapep PF00132.24 ELR24630.1 - 2.2e-10 39.9 33.8 9e-06 25.2 3.3 7.5 5 3 2 7 7 7 7 Bacterial transferase hexapeptide (six repeats) F-box-like PF12937.7 ELR24631.1 - 2e-07 30.8 1.2 4.8e-07 29.6 1.2 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ELR24631.1 - 0.028 14.3 1.0 0.06 13.3 1.0 1.5 1 0 0 1 1 1 0 F-box domain WD40 PF00400.32 ELR24632.1 - 9.2e-26 89.6 9.2 0.00019 22.1 0.0 7.5 7 0 0 7 7 7 6 WD domain, G-beta repeat F-box-like PF12937.7 ELR24632.1 - 1.4e-10 40.9 0.0 2.8e-10 39.9 0.0 1.6 1 0 0 1 1 1 1 F-box-like ANAPC4_WD40 PF12894.7 ELR24632.1 - 6e-10 39.3 1.2 0.3 11.4 0.0 6.0 1 1 6 7 7 7 2 Anaphase-promoting complex subunit 4 WD40 domain F-box PF00646.33 ELR24632.1 - 4e-08 32.9 0.2 7e-08 32.2 0.2 1.4 1 0 0 1 1 1 1 F-box domain zf-C3HC4_3 PF13920.6 ELR24632.1 - 4.3e-08 32.9 8.5 8.7e-08 31.9 8.5 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 ELR24632.1 - 1.1e-07 31.7 7.7 1.1e-07 31.7 7.7 2.3 2 1 0 2 2 2 1 RING-type zinc-finger zf-C3HC4 PF00097.25 ELR24632.1 - 5.6e-07 29.3 13.1 1e-06 28.5 13.1 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Nup160 PF11715.8 ELR24632.1 - 1.5e-06 27.2 6.3 0.074 11.7 0.0 4.8 3 2 2 5 5 5 3 Nucleoporin Nup120/160 zf-C3HC4_2 PF13923.6 ELR24632.1 - 2.8e-06 27.1 12.6 5.3e-06 26.2 12.6 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 ELR24632.1 - 7.5e-06 26.0 13.8 1.4e-05 25.1 13.8 1.4 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING BBS2_Mid PF14783.6 ELR24632.1 - 2.2e-05 24.4 0.1 0.042 13.9 0.0 4.0 2 1 3 5 5 5 1 Ciliary BBSome complex subunit 2, middle region zf-RING_5 PF14634.6 ELR24632.1 - 3.4e-05 23.7 12.3 6.9e-05 22.7 12.3 1.6 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_2 PF13639.6 ELR24632.1 - 6.8e-05 23.1 12.6 0.00014 22.1 12.6 1.6 1 0 0 1 1 1 1 Ring finger domain PQQ_2 PF13360.6 ELR24632.1 - 0.00022 20.9 8.0 0.0066 16.1 8.2 2.8 1 1 0 1 1 1 1 PQQ-like domain DUF1513 PF07433.11 ELR24632.1 - 0.0011 18.2 0.4 0.38 9.8 0.1 2.7 2 1 1 3 3 3 1 Protein of unknown function (DUF1513) WD40_like PF17005.5 ELR24632.1 - 0.0016 17.8 0.0 3.1 7.0 0.0 2.5 1 1 1 3 3 3 2 WD40-like domain zf-RING_10 PF16685.5 ELR24632.1 - 0.0072 16.4 6.8 0.015 15.5 6.8 1.5 1 0 0 1 1 1 1 zinc RING finger of MSL2 PALB2_WD40 PF16756.5 ELR24632.1 - 0.0081 15.1 0.6 4.3 6.2 0.0 3.6 2 1 1 3 3 3 1 Partner and localizer of BRCA2 WD40 domain Urease_beta PF00699.20 ELR24632.1 - 0.019 15.0 0.0 0.054 13.5 0.0 1.8 1 0 0 1 1 1 0 Urease beta subunit Elongin_A PF06881.11 ELR24632.1 - 0.021 15.3 0.0 0.039 14.5 0.0 1.3 1 0 0 1 1 1 0 RNA polymerase II transcription factor SIII (Elongin) subunit A Prok-RING_4 PF14447.6 ELR24632.1 - 0.028 14.3 9.5 0.064 13.1 9.5 1.6 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 DUF5046 PF16465.5 ELR24632.1 - 0.067 12.6 1.8 9.1 5.6 0.3 3.9 1 1 2 4 4 4 0 Domain of unknown function (DUF5046) zf-RING_6 PF14835.6 ELR24632.1 - 0.49 10.3 5.5 0.93 9.4 5.5 1.4 1 0 0 1 1 1 0 zf-RING of BARD1-type protein zf-RING_4 PF14570.6 ELR24632.1 - 4.4 7.2 11.1 11 5.9 11.1 1.8 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain RhoGAP PF00620.27 ELR24633.1 - 2e-34 118.6 0.2 2e-34 118.6 0.2 3.5 4 0 0 4 4 4 1 RhoGAP domain LRR_4 PF12799.7 ELR24633.1 - 9.8e-10 38.5 0.2 8.3e-06 26.1 0.2 2.7 2 0 0 2 2 2 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 ELR24633.1 - 1.8e-08 34.0 0.6 5.2e-08 32.5 0.6 1.9 1 0 0 1 1 1 1 Leucine rich repeat FYVE PF01363.21 ELR24633.1 - 9.2e-08 32.1 3.3 2.4e-07 30.8 3.3 1.7 1 0 0 1 1 1 1 FYVE zinc finger FH2 PF02181.23 ELR24634.1 - 5e-79 266.1 7.4 5e-79 266.1 7.4 2.2 3 0 0 3 3 3 1 Formin Homology 2 Domain FlgT_C PF16538.5 ELR24634.1 - 0.15 12.6 1.4 0.61 10.7 0.3 2.4 1 1 1 2 2 2 0 Flagellar assembly protein T, C-terminal domain H-kinase_dim PF02895.14 ELR24634.1 - 5.1 7.6 13.6 7.8 7.0 0.0 4.8 5 0 0 5 5 5 0 Signal transducing histidine kinase, homodimeric domain MSA-2c PF12238.8 ELR24635.1 - 0.31 11.0 3.8 0.34 10.9 3.8 1.0 1 0 0 1 1 1 0 Merozoite surface antigen 2c DUF3402 PF11882.8 ELR24636.1 - 3.3e-57 194.6 3.8 1.5e-39 136.4 1.5 3.0 1 1 0 2 2 2 2 Domain of unknown function (DUF3402) N1221 PF07923.13 ELR24636.1 - 6.1e-05 22.4 0.0 0.00012 21.4 0.0 1.4 1 0 0 1 1 1 1 N1221-like protein T3SS_needle_reg PF09025.10 ELR24637.1 - 0.055 13.5 0.1 0.092 12.7 0.1 1.5 1 0 0 1 1 1 0 YopR, type III needle-polymerisation regulator p31comet PF06581.12 ELR24637.1 - 0.12 11.6 0.0 0.19 10.9 0.0 1.3 1 0 0 1 1 1 0 Mad1 and Cdc20-bound-Mad2 binding WXG100 PF06013.12 ELR24637.1 - 0.15 12.3 3.0 0.11 12.7 0.9 1.7 2 0 0 2 2 2 0 Proteins of 100 residues with WXG PTPA PF03095.15 ELR24638.1 - 2.6e-112 375.2 0.0 2.9e-112 375.0 0.0 1.0 1 0 0 1 1 1 1 Phosphotyrosyl phosphate activator (PTPA) protein ORMDL PF04061.14 ELR24638.1 - 0.1 12.4 0.0 0.23 11.3 0.0 1.5 1 0 0 1 1 1 0 ORMDL family Rax2 PF12768.7 ELR24639.1 - 0.049 13.1 0.1 0.11 12.0 0.0 1.5 2 0 0 2 2 2 0 Cortical protein marker for cell polarity DUF4448 PF14610.6 ELR24639.1 - 0.13 12.0 0.0 0.2 11.4 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4448) SKG6 PF08693.10 ELR24639.1 - 5.3 6.5 24.2 0.073 12.5 14.8 2.8 3 0 0 3 3 3 0 Transmembrane alpha-helix domain LRR_8 PF13855.6 ELR24640.1 - 2.5e-13 49.5 19.7 2.7e-05 23.9 0.6 5.3 2 1 3 5 5 5 4 Leucine rich repeat LRR_4 PF12799.7 ELR24640.1 - 1.7e-05 25.1 21.0 0.081 13.4 0.5 5.4 4 1 2 6 6 6 4 Leucine Rich repeats (2 copies) Adeno_PIX PF03955.14 ELR24640.1 - 0.012 15.8 1.3 4 7.7 0.1 2.9 3 0 0 3 3 3 0 Adenovirus hexon-associated protein (IX) LRR19-TM PF15176.6 ELR24640.1 - 0.24 11.4 0.9 0.75 9.8 0.0 2.2 3 0 0 3 3 3 0 Leucine-rich repeat family 19 TM domain Ras PF00071.22 ELR24642.1 - 9.9e-11 41.5 0.1 1.2e-10 41.2 0.1 1.1 1 0 0 1 1 1 1 Ras family Foie-gras_1 PF11817.8 ELR24645.1 - 1.7e-40 139.3 0.4 2.7e-40 138.6 0.4 1.4 1 0 0 1 1 1 1 Foie gras liver health family 1 Gryzun PF07919.12 ELR24645.1 - 0.00041 19.2 0.1 0.00069 18.5 0.1 1.3 1 0 0 1 1 1 1 Gryzun, putative trafficking through Golgi DUF4810 PF16068.5 ELR24645.1 - 0.075 13.6 0.0 0.51 10.9 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4810) PPR_2 PF13041.6 ELR24646.1 - 3.1e-26 91.3 0.0 2.8e-05 24.2 0.0 7.5 7 1 1 8 8 8 5 PPR repeat family PPR_3 PF13812.6 ELR24646.1 - 4.2e-23 81.2 0.1 7.6e-05 22.7 0.0 7.2 6 1 1 7 7 7 5 Pentatricopeptide repeat domain PPR_long PF17177.4 ELR24646.1 - 4.1e-15 55.7 0.3 0.00016 21.2 0.0 4.3 1 1 0 4 4 4 3 Pentacotripeptide-repeat region of PRORP PPR PF01535.20 ELR24646.1 - 1e-12 47.4 0.1 0.028 14.6 0.0 8.1 9 0 0 9 9 9 2 PPR repeat RPM2 PF08579.11 ELR24646.1 - 1.2e-07 32.1 0.3 0.0094 16.3 0.0 3.9 3 2 0 3 3 3 2 Mitochondrial ribonuclease P subunit (RPM2) PPR_1 PF12854.7 ELR24646.1 - 0.00086 19.0 1.6 7.4 6.4 0.0 4.5 6 0 0 6 6 6 1 PPR repeat ATP13 PF12921.7 ELR24646.1 - 0.0038 17.1 0.0 0.16 11.8 0.0 3.2 3 1 0 3 3 3 1 Mitochondrial ATPase expression MNE1 PF13762.6 ELR24646.1 - 0.035 14.1 0.0 0.69 9.9 0.0 2.9 3 1 0 3 3 3 0 Mitochondrial splicing apparatus component Prominin PF05478.11 ELR24646.1 - 0.054 11.4 0.0 0.086 10.8 0.0 1.2 1 0 0 1 1 1 0 Prominin ECSIT PF06239.11 ELR24646.1 - 0.083 12.0 0.0 10 5.2 0.0 2.9 1 1 1 2 2 2 0 Evolutionarily conserved signalling intermediate in Toll pathway PhoU PF01895.19 ELR24646.1 - 0.26 11.8 1.1 3.5 8.2 0.1 2.9 3 0 0 3 3 3 0 PhoU domain Tannase PF07519.11 ELR24647.1 - 0.0021 17.1 0.9 0.014 14.4 0.0 2.0 2 0 0 2 2 2 2 Tannase and feruloyl esterase ADH_zinc_N PF00107.26 ELR24648.1 - 2e-27 95.8 0.1 3.6e-27 94.9 0.1 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 ELR24648.1 - 3.7e-19 70.1 0.0 6e-19 69.4 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 ELR24648.1 - 5.5e-09 35.9 0.0 1.2e-06 28.4 0.0 2.5 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain Glu_dehyd_C PF16912.5 ELR24648.1 - 1e-06 28.4 0.1 1.4e-06 27.9 0.1 1.1 1 0 0 1 1 1 1 Glucose dehydrogenase C-terminus Semialdhyde_dh PF01118.24 ELR24648.1 - 0.0014 19.0 0.1 0.0036 17.7 0.1 1.7 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain NAD_binding_10 PF13460.6 ELR24648.1 - 0.004 17.1 0.5 0.049 13.5 0.3 2.1 2 0 0 2 2 2 1 NAD(P)H-binding ELFV_dehydrog PF00208.21 ELR24648.1 - 0.023 14.4 0.0 0.036 13.8 0.0 1.2 1 0 0 1 1 1 0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase TrkA_N PF02254.18 ELR24648.1 - 0.043 14.1 0.0 0.12 12.6 0.0 1.7 2 0 0 2 2 2 0 TrkA-N domain adh_short PF00106.25 ELR24648.1 - 0.11 11.9 0.7 0.21 11.0 0.1 1.8 2 0 0 2 2 2 0 short chain dehydrogenase DapB_N PF01113.20 ELR24648.1 - 0.13 12.4 0.1 0.8 9.8 0.1 2.0 2 0 0 2 2 2 0 Dihydrodipicolinate reductase, N-terminus DEAD PF00270.29 ELR24649.1 - 6.6e-44 149.8 0.1 1.2e-43 148.9 0.1 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ELR24649.1 - 3.7e-23 82.0 0.0 1.4e-20 73.7 0.0 2.4 2 0 0 2 2 2 2 Helicase conserved C-terminal domain ResIII PF04851.15 ELR24649.1 - 4.4e-08 33.3 0.3 7.7e-08 32.5 0.0 1.6 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Apc15p PF05841.11 ELR24649.1 - 0.0059 17.4 0.5 0.019 15.7 0.5 1.9 1 0 0 1 1 1 1 Apc15p protein FoP_duplication PF13865.6 ELR24649.1 - 2 9.0 24.7 1.1 9.8 18.1 2.7 2 0 0 2 2 2 0 C-terminal duplication domain of Friend of PRMT1 LRR_4 PF12799.7 ELR24650.1 - 0.035 14.5 14.0 0.92 10.0 0.2 6.1 4 1 0 5 5 5 0 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 ELR24650.1 - 0.065 13.3 10.4 12 6.2 0.0 6.0 6 0 0 6 6 6 0 Leucine Rich repeat CLU PF13236.6 ELR24651.1 - 1.1e-29 103.8 0.0 1.4e-13 51.2 0.0 2.6 1 1 1 2 2 2 2 Clustered mitochondria DEP PF00610.21 ELR24651.1 - 3.8e-12 46.1 0.1 7.2e-12 45.2 0.1 1.5 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) TetR_C_15 PF17918.1 ELR24651.1 - 0.15 12.8 2.3 0.7 10.7 2.3 2.2 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain eIF3_p135 PF12807.7 ELR24651.1 - 0.21 11.6 0.5 0.85 9.6 0.0 2.3 2 0 0 2 2 2 0 Translation initiation factor eIF3 subunit 135 SAP PF02037.27 ELR24652.1 - 3.2e-06 26.8 0.0 3.2e-06 26.8 0.0 2.8 4 0 0 4 4 4 1 SAP domain SMI1_KNR4 PF09346.10 ELR24652.1 - 5e-06 26.9 0.0 1.3e-05 25.6 0.0 1.7 1 0 0 1 1 1 1 SMI1 / KNR4 family (SUKH-1) LUC7 PF03194.15 ELR24652.1 - 0.011 15.5 1.1 0.011 15.5 1.1 2.0 2 0 0 2 2 2 0 LUC7 N_terminus HDA2-3 PF11496.8 ELR24652.1 - 0.011 14.9 2.0 0.033 13.4 2.0 1.7 1 0 0 1 1 1 0 Class II histone deacetylase complex subunits 2 and 3 Noggin PF05806.12 ELR24654.1 - 0.98 9.3 5.1 2.2 8.1 5.1 1.5 1 0 0 1 1 1 0 Noggin BTB PF00651.31 ELR24655.1 - 4.7e-25 88.0 0.1 9.4e-22 77.4 0.0 2.4 1 1 1 2 2 2 2 BTB/POZ domain WD40 PF00400.32 ELR24656.1 - 4.6e-21 74.7 10.7 0.00011 22.9 0.0 6.2 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ELR24656.1 - 7.7e-08 32.5 0.0 0.87 9.9 0.0 4.6 1 1 4 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 ELR24656.1 - 8.1e-05 22.6 0.0 0.0081 16.1 0.0 2.5 2 0 0 2 2 2 1 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 ELR24656.1 - 0.0041 15.8 0.5 0.02 13.5 0.1 2.1 1 1 1 2 2 2 1 Nucleoporin Nup120/160 Nucleoporin_N PF08801.11 ELR24656.1 - 0.038 12.7 0.1 0.22 10.2 0.0 2.0 1 1 1 2 2 2 0 Nup133 N terminal like NmrA PF05368.13 ELR24657.1 - 7e-46 156.7 0.0 1.1e-45 156.0 0.0 1.3 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 ELR24657.1 - 1.6e-13 50.9 0.5 5.1e-13 49.3 0.5 1.9 1 1 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 ELR24657.1 - 5.6e-05 22.7 0.1 0.0001 21.8 0.1 1.5 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family KR PF08659.10 ELR24657.1 - 0.024 14.5 0.3 0.054 13.4 0.1 1.7 2 0 0 2 2 2 0 KR domain GDP_Man_Dehyd PF16363.5 ELR24657.1 - 0.056 12.8 0.1 0.095 12.1 0.1 1.3 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase MutS_V PF00488.21 ELR24658.1 - 5e-83 277.8 0.5 9.5e-83 276.9 0.5 1.5 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.18 ELR24658.1 - 2.9e-18 66.8 9.9 1.2e-17 64.7 6.0 3.4 2 1 0 2 2 2 1 MutS domain III MutS_IV PF05190.18 ELR24658.1 - 4.5e-13 49.4 3.6 1.1e-12 48.1 3.6 1.7 1 0 0 1 1 1 1 MutS family domain IV MutS_II PF05188.17 ELR24658.1 - 1.6e-08 34.9 0.4 0.0028 17.9 0.0 2.9 3 0 0 3 3 3 2 MutS domain II MutS_I PF01624.20 ELR24658.1 - 8.8e-05 22.7 0.0 0.00024 21.3 0.0 1.8 1 0 0 1 1 1 1 MutS domain I DUF4957 PF16318.5 ELR24658.1 - 0.022 14.7 0.0 0.043 13.7 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4957) AAA_23 PF13476.6 ELR24658.1 - 2.6 8.5 0.0 2.6 8.5 0.0 3.0 2 1 0 2 2 2 0 AAA domain adh_short PF00106.25 ELR24659.1 - 3e-31 108.4 0.1 2.6e-24 85.8 0.1 2.2 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 ELR24659.1 - 1.7e-25 89.9 0.2 1.3e-19 70.7 0.2 2.1 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ELR24659.1 - 4.8e-08 33.1 0.1 6.8e-08 32.6 0.1 1.3 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 ELR24659.1 - 9.2e-05 22.0 0.3 0.0017 17.9 0.3 2.0 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family adh_short PF00106.25 ELR24660.1 - 1.7e-36 125.5 1.1 4.5e-28 98.0 0.5 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 ELR24660.1 - 9.4e-30 103.9 2.2 4.4e-21 75.5 0.5 2.2 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ELR24660.1 - 6.5e-09 35.9 0.3 9.4e-09 35.4 0.3 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 ELR24660.1 - 0.0007 19.1 1.6 0.0062 16.0 1.6 2.0 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NmrA PF05368.13 ELR24660.1 - 0.047 13.3 0.5 0.047 13.3 0.5 1.8 2 0 0 2 2 2 0 NmrA-like family Pkinase_Tyr PF07714.17 ELR24661.1 - 4.5e-44 150.7 0.1 2.5e-43 148.3 0.0 2.3 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.25 ELR24661.1 - 7.5e-30 104.2 0.0 2.4e-29 102.5 0.0 1.9 2 0 0 2 2 1 1 Protein kinase domain Kelch_4 PF13418.6 ELR24661.1 - 6e-18 64.6 2.8 1.2e-09 38.0 0.1 4.2 5 0 0 5 5 5 2 Galactose oxidase, central domain Kelch_6 PF13964.6 ELR24661.1 - 6.8e-16 57.9 0.2 3.3e-06 27.2 0.1 4.2 2 1 1 3 3 3 2 Kelch motif Kelch_1 PF01344.25 ELR24661.1 - 6.2e-14 51.3 0.1 1.4e-05 24.5 0.0 4.2 4 0 0 4 4 4 2 Kelch motif Kelch_5 PF13854.6 ELR24661.1 - 3.5e-13 49.2 0.6 1.8e-07 31.0 0.2 3.0 2 0 0 2 2 2 2 Kelch motif Kelch_3 PF13415.6 ELR24661.1 - 3.9e-11 42.9 19.3 5.6e-08 32.9 0.0 6.1 7 0 0 7 7 6 2 Galactose oxidase, central domain Kelch_2 PF07646.15 ELR24661.1 - 4.6e-09 35.9 4.4 0.00015 21.6 0.1 4.5 6 0 0 6 6 5 2 Kelch motif Carbpep_Y_N PF05388.11 ELR24661.1 - 0.0028 18.2 2.3 2 9.0 0.0 2.7 2 0 0 2 2 2 2 Carboxypeptidase Y pro-peptide Fez1 PF06818.15 ELR24661.1 - 0.033 14.6 25.9 0.027 14.9 7.2 2.5 2 0 0 2 2 2 0 Fez1 Mer2 PF09074.10 ELR24661.1 - 0.18 11.6 23.2 0.29 10.9 6.3 2.4 2 0 0 2 2 2 0 Mer2 DinB_2 PF12867.7 ELR24661.1 - 1.3 9.6 5.1 21 5.6 0.1 4.0 3 1 1 4 4 4 0 DinB superfamily Prominin PF05478.11 ELR24661.1 - 1.3 6.9 12.4 0.96 7.3 2.3 2.1 2 0 0 2 2 2 0 Prominin E3_UbLigase_R4 PF13764.6 ELR24661.1 - 4.7 5.2 20.4 0.3 9.2 4.5 2.1 2 0 0 2 2 2 0 E3 ubiquitin-protein ligase UBR4 PP2C PF00481.21 ELR24663.1 - 8.9e-50 169.7 0.4 5.9e-28 98.2 0.1 2.3 2 0 0 2 2 2 2 Protein phosphatase 2C Ribosomal_60s PF00428.19 ELR24663.1 - 0.43 11.2 3.1 5.8 7.6 1.1 2.8 2 0 0 2 2 2 0 60s Acidic ribosomal protein Voltage_CLC PF00654.20 ELR24664.1 - 9.9e-80 268.4 16.6 9.9e-80 268.4 16.6 2.6 2 1 1 3 3 3 1 Voltage gated chloride channel CBS PF00571.28 ELR24664.1 - 1.6e-13 50.9 0.0 1.8e-06 28.2 0.0 2.8 2 0 0 2 2 2 2 CBS domain DGCR6 PF07324.11 ELR24665.1 - 1.3e-21 77.1 1.4 5.5e-21 75.1 1.4 2.0 2 0 0 2 2 2 1 DiGeorge syndrome critical region 6 (DGCR6) protein DUF1911 PF08929.10 ELR24665.1 - 1.5 9.7 4.0 2 9.2 1.3 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF1911) Pkinase_Tyr PF07714.17 ELR24667.1 - 4.7e-53 180.1 0.0 7.6e-53 179.4 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ELR24667.1 - 4.6e-41 140.9 0.0 1.1e-40 139.7 0.0 1.6 2 0 0 2 2 2 1 Protein kinase domain Kelch_3 PF13415.6 ELR24667.1 - 5.5e-10 39.3 0.3 3.4e-05 24.0 0.0 2.7 2 0 0 2 2 2 2 Galactose oxidase, central domain Kelch_4 PF13418.6 ELR24667.1 - 2.3e-08 33.9 0.1 0.012 15.6 0.0 3.2 2 1 0 2 2 2 2 Galactose oxidase, central domain Kelch_6 PF13964.6 ELR24667.1 - 6.5e-08 32.6 0.0 2.8e-05 24.2 0.0 3.4 2 1 1 3 3 3 1 Kelch motif Kelch_5 PF13854.6 ELR24667.1 - 1.4e-07 31.3 0.1 0.0033 17.4 0.0 2.6 2 0 0 2 2 2 2 Kelch motif Kelch_1 PF01344.25 ELR24667.1 - 1.7e-05 24.3 0.0 0.01 15.4 0.0 3.6 4 1 0 4 4 4 1 Kelch motif Kelch_2 PF07646.15 ELR24667.1 - 0.00014 21.7 0.1 0.025 14.6 0.0 3.6 4 0 0 4 4 4 1 Kelch motif Pkinase_fungal PF17667.1 ELR24667.1 - 0.00078 18.3 3.3 0.0018 17.1 3.3 1.6 1 1 0 1 1 1 1 Fungal protein kinase APH PF01636.23 ELR24667.1 - 0.0039 17.2 2.2 0.36 10.7 0.0 3.6 3 1 1 4 4 4 1 Phosphotransferase enzyme family DUF1664 PF07889.12 ELR24667.1 - 0.3 11.1 7.7 0.54 10.3 6.1 2.2 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) zf-C4H2 PF10146.9 ELR24667.1 - 0.57 10.5 15.5 0.037 14.3 10.0 1.8 2 0 0 2 2 2 0 Zinc finger-containing protein DUF1690 PF07956.11 ELR24667.1 - 2.5 8.5 11.5 1.9 8.9 9.6 1.7 2 0 0 2 2 1 0 Protein of Unknown function (DUF1690) DUF1180 PF06679.12 ELR24667.1 - 3 8.2 5.7 6.2 7.2 5.7 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) SapB_1 PF05184.15 ELR24668.1 - 8.1e-14 51.3 0.5 8.1e-14 51.3 0.5 1.9 2 0 0 2 2 2 1 Saposin-like type B, region 1 SapB_2 PF03489.17 ELR24668.1 - 4.2e-11 42.7 0.5 4.3e-10 39.5 0.1 2.6 2 0 0 2 2 2 1 Saposin-like type B, region 2 HTH_28 PF13518.6 ELR24668.1 - 0.004 17.3 0.0 0.0075 16.4 0.0 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain HEAT_EZ PF13513.6 ELR24668.1 - 0.076 13.5 0.5 0.2 12.2 0.1 1.9 2 1 0 2 2 2 0 HEAT-like repeat TPT PF03151.16 ELR24669.1 - 2e-27 96.3 18.4 3.4e-19 69.3 4.4 2.0 1 1 1 2 2 2 2 Triose-phosphate Transporter family EamA PF00892.20 ELR24669.1 - 2.8e-08 34.0 8.5 2.8e-08 34.0 8.5 2.2 2 0 0 2 2 2 1 EamA-like transporter family UAA PF08449.11 ELR24669.1 - 5.6e-05 22.5 12.9 7.7e-05 22.0 12.9 1.2 1 0 0 1 1 1 1 UAA transporter family Voltage_CLC PF00654.20 ELR24670.1 - 1.9e-83 280.6 18.8 2.5e-83 280.3 18.8 1.1 1 0 0 1 1 1 1 Voltage gated chloride channel CBS PF00571.28 ELR24670.1 - 8.9e-16 58.1 0.6 7.1e-07 29.6 0.2 2.5 2 0 0 2 2 2 2 CBS domain Robl_LC7 PF03259.17 ELR24670.1 - 0.0038 17.0 0.1 1.2 8.9 0.0 2.6 2 0 0 2 2 2 2 Roadblock/LC7 domain FA_desaturase PF00487.24 ELR24670.1 - 0.8 9.5 7.8 0.053 13.3 0.4 2.4 1 1 0 2 2 2 0 Fatty acid desaturase DUF4778 PF16008.5 ELR24671.1 - 0.04 14.0 0.4 0.041 14.0 0.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4778) CrgA PF06781.12 ELR24671.1 - 1.9 8.6 3.4 3.4 7.8 3.4 1.4 1 0 0 1 1 1 0 Cell division protein CrgA ATP-synt_ab_Xtn PF16886.5 ELR24674.1 - 4.9e-33 113.6 0.0 9.2e-31 106.2 0.0 2.4 2 0 0 2 2 2 2 ATPsynthase alpha/beta subunit N-term extension ATP-synt_ab PF00006.25 ELR24674.1 - 9.1e-32 110.4 0.0 1.7e-31 109.6 0.0 1.4 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_N PF02874.23 ELR24674.1 - 0.021 15.3 0.6 0.059 13.9 0.6 1.8 1 0 0 1 1 1 0 ATP synthase alpha/beta family, beta-barrel domain Cas_Csd1 PF09709.10 ELR24674.1 - 0.16 10.6 0.0 0.24 10.0 0.0 1.1 1 0 0 1 1 1 0 CRISPR-associated protein (Cas_Csd1) FMN_red PF03358.15 ELR24675.1 - 1.4e-36 125.6 0.0 2.1e-36 125.0 0.0 1.3 1 0 0 1 1 1 1 NADPH-dependent FMN reductase Flavodoxin_2 PF02525.17 ELR24675.1 - 2.4e-07 30.7 0.0 4.8e-07 29.7 0.0 1.5 1 0 0 1 1 1 1 Flavodoxin-like fold Beta_helix PF13229.6 ELR24676.1 - 0.0022 17.9 8.8 0.19 11.6 2.1 3.3 1 1 1 2 2 2 2 Right handed beta helix region Prothymosin PF03247.14 ELR24677.1 - 0.45 11.0 20.7 0.62 10.6 20.7 1.2 1 0 0 1 1 1 0 Prothymosin/parathymosin family ATP-synt_E PF05680.12 ELR24677.1 - 5.4 7.4 6.9 10 6.5 6.9 1.4 1 0 0 1 1 1 0 ATP synthase E chain DUF3500 PF12006.8 ELR24678.1 - 0.071 12.6 0.1 0.077 12.5 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3500) SNARE_assoc PF09335.11 ELR24679.1 - 7.7e-18 65.1 4.4 7.7e-18 65.1 4.4 2.3 3 1 0 3 3 3 1 SNARE associated Golgi protein AIF-MLS PF14962.6 ELR24679.1 - 0.00027 21.0 0.5 0.00042 20.3 0.5 1.2 1 0 0 1 1 1 1 Mitochondria Localisation Sequence Tetraspanin PF00335.20 ELR24679.1 - 0.055 13.2 0.0 7.1 6.3 0.1 2.3 2 0 0 2 2 2 0 Tetraspanin family LapA_dom PF06305.11 ELR24679.1 - 0.079 12.8 8.3 15 5.5 2.4 4.0 4 0 0 4 4 4 0 Lipopolysaccharide assembly protein A domain DUF4199 PF13858.6 ELR24679.1 - 0.71 10.2 8.5 48 4.3 0.0 3.6 2 2 0 2 2 2 0 Protein of unknown function (DUF4199) Phage_holin_2_1 PF04971.12 ELR24679.1 - 1.1 9.3 4.5 0.25 11.4 0.4 2.0 2 0 0 2 2 2 0 Bacteriophage P21 holin S CDP-OH_P_transf PF01066.21 ELR24680.1 - 2.6e-12 47.3 0.6 9.8e-12 45.5 0.0 2.2 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase CUE PF02845.16 ELR24681.1 - 5.5e-05 22.8 0.0 8.2e-05 22.2 0.0 1.3 1 0 0 1 1 1 1 CUE domain ATE_C PF04377.15 ELR24682.1 - 1.6e-45 155.0 4.9 3e-45 154.1 4.9 1.5 1 0 0 1 1 1 1 Arginine-tRNA-protein transferase, C terminus ATE_N PF04376.13 ELR24682.1 - 6.8e-08 32.8 0.4 1.2e-06 28.8 0.4 2.5 1 1 0 1 1 1 1 Arginine-tRNA-protein transferase, N terminus Arg_tRNA_synt_N PF03485.16 ELR24682.1 - 0.045 14.3 0.2 0.35 11.5 0.0 2.4 2 1 0 2 2 2 0 Arginyl tRNA synthetase N terminal domain Acetyltransf_6 PF13480.7 ELR24682.1 - 0.19 11.9 1.6 1.1 9.4 0.0 2.4 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain Apis_Csd PF11671.8 ELR24682.1 - 2.4 8.1 6.8 0.18 11.8 0.9 2.2 2 0 0 2 2 2 0 Complementary sex determiner protein SAPS PF04499.15 ELR24682.1 - 4.2 6.0 7.2 1.3 7.7 0.6 2.0 2 0 0 2 2 2 0 SIT4 phosphatase-associated protein Filamin PF00630.19 ELR24683.1 - 2.5e-94 310.9 5.9 7.1e-21 75.0 0.1 5.2 5 0 0 5 5 5 5 Filamin/ABP280 repeat CH PF00307.31 ELR24683.1 - 5.5e-44 148.8 0.1 9.4e-24 83.7 0.0 2.3 2 0 0 2 2 2 2 Calponin homology (CH) domain Invasin_D3 PF09134.10 ELR24683.1 - 6.7e-23 80.8 17.3 0.00048 20.4 0.0 5.3 5 0 0 5 5 5 5 Invasin, domain 3 YtkA PF13115.6 ELR24683.1 - 9.3e-11 42.2 10.1 0.041 14.5 0.1 5.5 5 0 0 5 5 5 2 YtkA-like Y_Y_Y PF07495.13 ELR24683.1 - 2.2e-07 30.7 7.4 0.042 13.8 0.1 5.2 6 0 0 6 6 5 2 Y_Y_Y domain Big_1 PF02369.16 ELR24683.1 - 1e-06 28.7 9.6 0.035 14.1 0.0 5.1 6 0 0 6 6 6 2 Bacterial Ig-like domain (group 1) SdrD_B PF17210.3 ELR24683.1 - 3.2e-05 24.1 5.6 0.076 13.3 0.2 4.3 4 0 0 4 4 4 1 SdrD B-like domain DUF5060 PF16586.5 ELR24683.1 - 3.4e-05 24.1 0.2 2.7 8.4 0.0 4.0 3 0 0 3 3 3 2 Domain of unknown function (DUF5060) CAMSAP_CH PF11971.8 ELR24683.1 - 6.8e-05 22.6 0.0 0.068 13.0 0.0 2.4 2 0 0 2 2 2 2 CAMSAP CH domain Big_6 PF17936.1 ELR24683.1 - 0.00014 22.1 8.2 1.6 9.1 0.1 5.0 4 1 1 5 5 5 2 Bacterial Ig domain Wzt_C PF14524.6 ELR24683.1 - 0.00049 20.2 0.1 0.92 9.5 0.0 3.5 3 0 0 3 3 3 1 Wzt C-terminal domain CopC PF04234.12 ELR24683.1 - 0.00078 20.4 3.8 15 6.7 0.0 5.2 5 0 0 5 5 5 0 CopC domain PKD PF00801.20 ELR24683.1 - 0.0016 18.3 4.5 1.4 8.9 0.3 3.9 3 0 0 3 3 3 1 PKD domain Inhibitor_I42 PF09394.10 ELR24683.1 - 0.0038 17.6 1.3 5 7.6 0.0 3.8 2 1 1 3 3 3 1 Chagasin family peptidase inhibitor I42 bMG6 PF17962.1 ELR24683.1 - 0.018 15.2 1.6 9.7 6.4 0.0 4.6 5 1 0 5 5 4 0 Bacterial macroglobulin domain 6 Big_3_5 PF16640.5 ELR24683.1 - 0.018 15.2 12.1 1.7 8.9 0.4 4.6 4 0 0 4 4 4 0 Bacterial Ig-like domain (group 3) Neurexophilin PF06312.12 ELR24683.1 - 0.019 14.4 0.2 27 4.1 0.0 4.0 4 0 0 4 4 4 0 Neurexophilin HepII_C PF18675.1 ELR24683.1 - 0.019 15.0 0.8 5.5 7.2 0.0 4.0 4 0 0 4 4 4 0 Heparinase II C-terminal domain PapC_N PF13954.6 ELR24683.1 - 0.033 14.2 0.1 2.1 8.4 0.0 3.4 4 0 0 4 4 4 0 PapC N-terminal domain FixH PF05751.11 ELR24683.1 - 0.087 12.8 0.3 39 4.2 0.0 3.6 5 0 0 5 5 4 0 FixH Cadherin_5 PF17892.1 ELR24683.1 - 0.092 12.7 13.3 3.9 7.5 0.2 5.0 5 0 0 5 5 5 0 Cadherin-like domain DUF4258 PF14076.6 ELR24683.1 - 0.096 13.1 0.0 0.24 11.8 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4258) Big_3 PF07523.12 ELR24683.1 - 0.94 9.8 16.2 10 6.5 0.2 5.0 5 1 0 5 5 4 0 Bacterial Ig-like domain (group 3) DUF5011 PF16403.5 ELR24683.1 - 4.3 7.5 10.8 6.4 7.0 0.5 4.5 3 2 1 4 4 4 0 Domain of unknown function (DUF5011) LRR_4 PF12799.7 ELR24684.1 - 1.9e-12 47.1 0.6 0.24 11.9 0.1 5.5 3 1 1 5 5 5 4 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 ELR24684.1 - 8.3e-11 41.1 10.4 0.012 15.6 0.0 6.9 7 0 0 7 7 7 4 Leucine Rich repeat LRR_8 PF13855.6 ELR24684.1 - 2.3e-05 24.1 4.6 0.46 10.3 0.1 5.8 5 2 2 7 7 7 2 Leucine rich repeat LRR_1 PF00560.33 ELR24684.1 - 0.00016 21.8 0.8 15 6.6 0.0 5.9 6 1 0 6 6 6 1 Leucine Rich Repeat DBC1 PF14443.6 ELR24684.1 - 0.32 11.0 0.9 0.73 9.8 0.0 2.1 3 0 0 3 3 3 0 DBC1 Colipase PF01114.18 ELR24684.1 - 1.6 8.5 5.5 0.45 10.2 1.7 2.1 2 0 0 2 2 2 0 Colipase, N-terminal domain Melittin PF01372.17 ELR24684.1 - 3.2 7.9 4.4 28 4.9 0.1 3.1 4 0 0 4 4 4 0 Melittin LRR_4 PF12799.7 ELR24685.1 - 0.021 15.3 0.2 0.1 13.1 0.2 2.1 1 1 1 2 2 2 0 Leucine Rich repeats (2 copies) SIR2 PF02146.17 ELR24686.1 - 1.6e-14 54.3 0.0 2.3e-14 53.7 0.0 1.2 1 0 0 1 1 1 1 Sir2 family PH PF00169.29 ELR24687.1 - 5.4e-12 46.2 0.0 1.7e-11 44.5 0.0 1.9 1 1 0 1 1 1 1 PH domain Arc_trans_TRASH PF08394.10 ELR24687.1 - 0.018 15.4 3.0 0.043 14.1 3.0 1.5 1 0 0 1 1 1 0 Archaeal TRASH domain SNF2_N PF00176.23 ELR24689.1 - 4.5e-66 223.0 0.2 4.5e-66 223.0 0.2 1.6 2 0 0 2 2 2 1 SNF2 family N-terminal domain DBINO PF13892.6 ELR24689.1 - 2.6e-38 131.4 20.9 2.6e-38 131.4 20.9 2.2 3 0 0 3 3 3 1 DNA-binding domain Helicase_C PF00271.31 ELR24689.1 - 2.8e-20 72.7 0.0 8.6e-20 71.1 0.0 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 ELR24689.1 - 0.00016 21.7 0.3 0.00045 20.3 0.0 2.0 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit HDA2-3 PF11496.8 ELR24689.1 - 0.00068 18.9 3.2 0.00087 18.5 0.0 2.6 3 0 0 3 3 3 1 Class II histone deacetylase complex subunits 2 and 3 TMEM51 PF15345.6 ELR24689.1 - 4.1 7.2 7.2 0.56 10.0 0.1 2.9 3 0 0 3 3 3 0 Transmembrane protein 51 EMG1 PF03587.14 ELR24690.1 - 2.7e-81 271.9 0.0 3.1e-81 271.7 0.0 1.0 1 0 0 1 1 1 1 EMG1/NEP1 methyltransferase PsiF_repeat PF07769.14 ELR24690.1 - 0.14 12.1 0.1 0.26 11.2 0.1 1.5 1 0 0 1 1 1 0 psiF repeat Flavodoxin_5 PF12724.7 ELR24691.1 - 0.059 13.6 0.3 0.12 12.7 0.3 1.4 1 0 0 1 1 1 0 Flavodoxin domain PA26 PF04636.13 ELR24691.1 - 1.6 7.5 5.6 2.1 7.2 5.6 1.2 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) AT_hook PF02178.19 ELR24691.1 - 5.4 7.2 80.1 0.17 11.8 6.2 5.6 5 0 0 5 5 5 0 AT hook motif Mitofilin PF09731.9 ELR24692.1 - 4.7 5.9 13.1 7.4 5.3 13.1 1.3 1 0 0 1 1 1 0 Mitochondrial inner membrane protein DUF2647 PF10839.8 ELR24693.1 - 0.067 13.3 0.4 0.11 12.5 0.3 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF2647) Ank_5 PF13857.6 ELR24694.1 - 6.1e-24 83.8 1.1 1.4e-08 34.9 0.1 4.2 2 1 2 4 4 4 4 Ankyrin repeats (many copies) Ank_2 PF12796.7 ELR24694.1 - 2.4e-22 79.3 0.0 2.6e-13 50.3 0.0 2.2 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ELR24694.1 - 2.4e-21 75.8 1.1 2.1e-08 34.5 0.1 3.4 2 1 2 4 4 4 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 ELR24694.1 - 4.5e-20 69.6 0.0 0.00011 22.3 0.0 4.5 5 0 0 5 5 5 3 Ankyrin repeat Ank PF00023.30 ELR24694.1 - 5.8e-19 67.6 2.8 5.1e-06 26.7 0.1 3.5 3 0 0 3 3 3 3 Ankyrin repeat IMUP PF15761.5 ELR24694.1 - 0.054 14.2 0.1 0.096 13.4 0.1 1.5 1 0 0 1 1 1 0 Immortalisation up-regulated protein EST1_DNA_bind PF10373.9 ELR24695.1 - 1.9e-25 89.9 0.0 2.9e-25 89.3 0.0 1.3 1 0 0 1 1 1 1 Est1 DNA/RNA binding domain EST1 PF10374.9 ELR24695.1 - 8.9e-06 26.4 5.7 2e-05 25.3 1.1 3.3 2 1 0 2 2 2 1 Telomerase activating protein Est1 TPR_11 PF13414.6 ELR24695.1 - 0.0054 16.4 3.5 0.0062 16.2 0.1 2.6 2 1 1 3 3 3 1 TPR repeat TPR_17 PF13431.6 ELR24695.1 - 0.0076 16.6 0.1 0.082 13.3 0.1 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat PARP PF00644.20 ELR24696.1 - 5.5e-64 215.4 1.0 2.7e-63 213.1 0.0 2.5 3 0 0 3 3 3 1 Poly(ADP-ribose) polymerase catalytic domain PARP_reg PF02877.14 ELR24696.1 - 1.6e-44 151.3 0.9 3.2e-44 150.3 0.9 1.5 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase, regulatory domain zf-PARP PF00645.18 ELR24696.1 - 1.3e-34 118.9 1.1 2.6e-16 60.3 0.1 3.4 2 0 0 2 2 2 2 Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region WGR PF05406.15 ELR24696.1 - 1.2e-18 66.9 0.2 1.2e-18 66.9 0.2 2.4 2 0 0 2 2 2 1 WGR domain PADR1 PF08063.12 ELR24696.1 - 2e-12 46.7 0.2 2e-12 46.7 0.2 1.9 2 0 0 2 2 2 1 PADR1 (NUC008) domain SAP PF02037.27 ELR24696.1 - 7e-12 44.8 1.2 7e-12 44.8 1.2 2.4 2 0 0 2 2 2 1 SAP domain BRCT PF00533.26 ELR24696.1 - 4e-11 43.1 0.0 1.3e-10 41.5 0.0 2.0 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 ELR24696.1 - 6e-05 23.4 0.0 0.00014 22.2 0.0 1.7 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain WHH PF14414.6 ELR24696.1 - 0.078 12.8 1.5 13 5.7 0.1 2.6 2 0 0 2 2 2 0 A nuclease of the HNH/ENDO VII superfamily with conserved WHH FANC_SAP PF18081.1 ELR24696.1 - 1.6 9.0 5.0 4.8 7.4 2.3 2.6 2 0 0 2 2 2 0 Fanconi anemia-associated nuclease SAP domain C2 PF00168.30 ELR24697.1 - 3.7e-23 81.8 0.0 4.9e-23 81.4 0.0 1.2 1 0 0 1 1 1 1 C2 domain WD40 PF00400.32 ELR24698.1 - 2.3e-52 173.8 28.0 1.2e-07 32.3 0.6 7.4 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ELR24698.1 - 2.4e-13 50.2 4.5 0.079 13.3 0.0 5.7 1 1 5 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ELR24698.1 - 1.9e-09 37.3 0.1 0.0001 21.8 0.0 2.9 1 1 0 2 2 2 2 WD40-like domain F-box-like PF12937.7 ELR24698.1 - 6.6e-08 32.3 0.0 1.2e-07 31.5 0.0 1.5 1 0 0 1 1 1 1 F-box-like Nup160 PF11715.8 ELR24698.1 - 2e-07 30.1 15.2 0.055 12.1 0.1 5.6 2 2 2 6 6 6 3 Nucleoporin Nup120/160 PALB2_WD40 PF16756.5 ELR24698.1 - 0.00013 21.0 9.1 0.55 9.1 0.2 5.1 2 1 3 5 5 5 1 Partner and localizer of BRCA2 WD40 domain F-box PF00646.33 ELR24698.1 - 0.00028 20.7 0.0 0.00055 19.7 0.0 1.5 1 0 0 1 1 1 1 F-box domain Ge1_WD40 PF16529.5 ELR24698.1 - 0.001 18.1 9.5 1 8.2 0.4 4.6 1 1 4 5 5 5 2 WD40 region of Ge1, enhancer of mRNA-decapping protein CDtoxinA PF03498.14 ELR24698.1 - 0.0013 18.4 0.4 2.2 7.9 0.1 3.7 2 1 1 3 3 3 1 Cytolethal distending toxin A/C domain DUF5046 PF16465.5 ELR24698.1 - 0.0017 17.9 0.2 0.88 9.0 0.1 2.6 1 1 0 2 2 2 2 Domain of unknown function (DUF5046) Nucleoporin_N PF08801.11 ELR24698.1 - 0.0021 16.9 2.2 4.1 6.1 0.0 4.1 1 1 3 4 4 4 1 Nup133 N terminal like Elongin_A PF06881.11 ELR24698.1 - 0.014 15.9 1.5 0.035 14.6 1.5 1.6 1 0 0 1 1 1 0 RNA polymerase II transcription factor SIII (Elongin) subunit A Rpn3_C PF08375.11 ELR24698.1 - 0.085 13.3 0.0 72 3.9 0.0 4.4 5 0 0 5 5 5 0 Proteasome regulatory subunit C-terminal F-box_4 PF15966.5 ELR24698.1 - 0.099 12.5 1.0 0.27 11.1 0.1 2.2 2 0 0 2 2 2 0 F-box PRANC PF09372.10 ELR24698.1 - 0.14 12.5 0.0 0.32 11.3 0.0 1.5 1 0 0 1 1 1 0 PRANC domain GCV_H PF01597.19 ELR24699.1 - 6.1e-44 148.8 0.7 7.4e-44 148.6 0.7 1.1 1 0 0 1 1 1 1 Glycine cleavage H-protein DUF3506 PF12014.8 ELR24699.1 - 0.097 12.7 0.1 0.13 12.2 0.1 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF3506) Inhibitor_I53 PF11714.8 ELR24700.1 - 2.3 8.5 5.4 17 5.7 0.0 2.7 2 0 0 2 2 2 0 Thrombin inhibitor Madanin UBX PF00789.20 ELR24701.1 - 6.1e-15 55.2 0.0 1.6e-14 53.8 0.0 1.7 1 0 0 1 1 1 1 UBX domain ASXH PF13919.6 ELR24702.1 - 0.1 12.6 0.0 0.15 12.0 0.0 1.2 1 0 0 1 1 1 0 Asx homology domain MIF4G PF02854.19 ELR24703.1 - 3.9e-59 199.9 23.6 1.2e-27 97.0 2.9 5.0 4 1 0 4 4 4 3 MIF4G domain Upf2 PF04050.14 ELR24703.1 - 8.1e-17 62.2 13.3 8.1e-17 62.2 13.3 5.4 3 3 2 5 5 5 1 Up-frameshift suppressor 2 Caldesmon PF02029.15 ELR24703.1 - 8 5.1 95.0 0.016 14.0 40.1 3.3 3 0 0 3 3 3 0 Caldesmon Mago_nashi PF02792.14 ELR24704.1 - 0.065 13.4 0.0 0.081 13.0 0.0 1.1 1 0 0 1 1 1 0 Mago nashi protein F-box-like PF12937.7 ELR24705.1 - 1.4e-14 53.7 0.3 2.8e-14 52.7 0.3 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ELR24705.1 - 2.8e-09 36.6 0.8 1.1e-08 34.8 0.1 2.2 1 1 1 2 2 2 1 F-box domain F-box_4 PF15966.5 ELR24705.1 - 9.1e-06 25.5 0.4 1.8e-05 24.6 0.4 1.5 1 0 0 1 1 1 1 F-box zf-RanBP PF00641.18 ELR24705.1 - 0.00051 19.3 2.0 0.00051 19.3 2.0 1.7 2 0 0 2 2 2 1 Zn-finger in Ran binding protein and others BTAD PF03704.17 ELR24705.1 - 0.012 16.1 1.0 1.5 9.3 0.4 2.3 2 0 0 2 2 2 0 Bacterial transcriptional activator domain ChaC PF04752.12 ELR24706.1 - 3.1e-47 160.9 0.1 3.6e-47 160.7 0.1 1.0 1 0 0 1 1 1 1 ChaC-like protein Mito_carr PF00153.27 ELR24707.1 - 2.1e-11 43.6 0.5 4.6e-08 32.9 0.0 3.0 2 1 1 3 3 3 2 Mitochondrial carrier protein Tim17 PF02466.19 ELR24708.1 - 1.2e-22 80.3 9.0 1.6e-22 80.0 9.0 1.1 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family Chromo PF00385.24 ELR24709.1 - 3.1e-11 43.0 0.0 9.2e-11 41.5 0.0 1.9 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain CENP-W PF15510.6 ELR24709.1 - 0.088 13.0 0.3 0.32 11.2 0.3 1.9 1 0 0 1 1 1 0 CENP-W protein CLPTM1 PF05602.12 ELR24709.1 - 1.5 7.7 12.2 2.5 7.0 12.2 1.3 1 0 0 1 1 1 0 Cleft lip and palate transmembrane protein 1 (CLPTM1) LRR_6 PF13516.6 ELR24711.1 - 8.1e-24 81.6 9.6 0.0031 17.4 0.0 10.7 11 0 0 11 11 11 4 Leucine Rich repeat LRR_4 PF12799.7 ELR24711.1 - 1.4e-08 34.9 28.4 0.053 14.0 0.8 7.7 4 2 2 8 8 8 5 Leucine Rich repeats (2 copies) F-box PF00646.33 ELR24711.1 - 0.00015 21.5 0.3 0.00051 19.8 0.3 1.9 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 ELR24711.1 - 0.00024 20.9 0.7 0.00071 19.4 0.7 1.8 1 0 0 1 1 1 1 F-box-like LRR_1 PF00560.33 ELR24711.1 - 0.00096 19.4 26.7 1.2 9.9 1.5 8.8 7 4 1 8 8 8 2 Leucine Rich Repeat FNIP PF05725.12 ELR24711.1 - 0.0015 18.6 12.9 0.41 10.9 0.1 6.3 7 1 0 7 7 7 1 FNIP Repeat PRANC PF09372.10 ELR24711.1 - 0.11 12.9 0.1 0.35 11.2 0.1 1.9 1 0 0 1 1 1 0 PRANC domain Casc1_N PF15927.5 ELR24711.1 - 0.39 10.4 19.2 0.019 14.7 12.6 2.1 2 0 0 2 2 2 0 Cancer susceptibility candidate 1 N-terminus LRR_8 PF13855.6 ELR24711.1 - 1.1 9.0 19.4 5.7 6.8 0.0 6.3 2 2 3 6 6 6 0 Leucine rich repeat PAT1 PF09770.9 ELR24712.1 - 1.2 7.3 10.5 1.6 6.9 10.5 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF4114 PF13448.6 ELR24713.1 - 3.6e-05 24.5 0.2 0.0001 23.0 0.2 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF4114) SKG6 PF08693.10 ELR24713.1 - 0.03 13.7 6.8 0.089 12.2 6.8 1.9 1 0 0 1 1 1 0 Transmembrane alpha-helix domain CXCXC PF03128.14 ELR24713.1 - 0.15 12.6 1.5 0.33 11.5 1.5 1.6 1 0 0 1 1 1 0 CXCXC repeat YecR PF13992.6 ELR24713.1 - 1.1 9.7 8.0 0.42 10.9 1.4 3.4 3 0 0 3 3 3 0 YecR-like lipoprotein RhoGEF PF00621.20 ELR24715.1 - 3.1e-47 161.1 0.2 6.1e-47 160.2 0.2 1.5 1 0 0 1 1 1 1 RhoGEF domain PH PF00169.29 ELR24715.1 - 2e-19 70.0 1.5 3.2e-09 37.2 0.6 3.8 3 1 0 3 3 3 3 PH domain PH_13 PF16652.5 ELR24715.1 - 0.0071 16.2 1.9 0.031 14.1 1.9 2.0 1 1 0 1 1 1 1 Pleckstrin homology domain PH_11 PF15413.6 ELR24715.1 - 0.041 14.3 2.0 0.71 10.3 0.2 3.6 3 1 0 3 3 3 0 Pleckstrin homology domain zf-Di19 PF05605.12 ELR24716.1 - 4.4e-10 39.7 8.7 1.7e-07 31.4 1.1 3.3 3 0 0 3 3 3 2 Drought induced 19 protein (Di19), zinc-binding Prok-RING_4 PF14447.6 ELR24716.1 - 0.0059 16.4 1.8 2.3 8.1 0.1 3.6 3 0 0 3 3 3 1 Prokaryotic RING finger family 4 zf-RING_2 PF13639.6 ELR24716.1 - 0.0067 16.7 8.2 0.0067 16.7 8.2 3.9 4 1 0 4 4 4 2 Ring finger domain zf-C2H2_12 PF18658.1 ELR24716.1 - 0.057 13.0 0.3 0.18 11.4 0.3 1.8 1 0 0 1 1 1 0 Zinc-finger C2H2-type zf-RING_5 PF14634.6 ELR24716.1 - 0.2 11.6 10.4 4.9 7.2 6.0 3.4 3 0 0 3 3 3 0 zinc-RING finger domain Slu7 PF11708.8 ELR24716.1 - 0.41 10.4 4.0 0.64 9.7 4.0 1.3 1 0 0 1 1 1 0 Pre-mRNA splicing Prp18-interacting factor zf-C2H2_4 PF13894.6 ELR24716.1 - 3.2 8.8 13.5 6.6 7.9 1.7 4.5 4 0 0 4 4 4 0 C2H2-type zinc finger HEAT_2 PF13646.6 ELR24717.1 - 6.3e-05 23.3 23.0 0.0051 17.2 1.7 6.9 4 2 2 6 6 6 3 HEAT repeats Cnd1 PF12717.7 ELR24717.1 - 0.0001 22.4 0.1 0.77 9.8 0.3 3.5 2 1 1 3 3 3 2 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.22 ELR24717.1 - 0.00042 20.3 13.4 2.9 8.4 0.2 7.8 7 0 0 7 7 7 2 HEAT repeat TIP120 PF08623.10 ELR24717.1 - 0.039 13.7 0.4 1.8 8.3 0.1 2.6 2 0 0 2 2 2 0 TATA-binding protein interacting (TIP20) Arm PF00514.23 ELR24717.1 - 0.041 13.9 7.3 0.092 12.8 0.4 3.8 4 0 0 4 4 4 0 Armadillo/beta-catenin-like repeat RasGEF_N_2 PF14663.6 ELR24717.1 - 0.08 13.3 3.2 3.9 7.9 0.5 3.6 3 2 0 3 3 3 0 Rapamycin-insensitive companion of mTOR RasGEF_N domain Asp PF00026.23 ELR24718.1 - 4.6e-109 364.7 0.0 5.5e-109 364.4 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 ELR24718.1 - 1.7e-12 47.9 0.4 1.6e-10 41.5 0.4 2.4 1 1 0 1 1 1 1 Xylanase inhibitor N-terminal SapB_2 PF03489.17 ELR24718.1 - 5.3e-11 42.4 2.7 5.3e-11 42.4 2.7 2.5 2 0 0 2 2 2 1 Saposin-like type B, region 2 SapB_1 PF05184.15 ELR24718.1 - 3e-05 23.9 1.8 4.8e-05 23.3 0.2 2.3 2 0 0 2 2 2 1 Saposin-like type B, region 1 TAXi_C PF14541.6 ELR24718.1 - 0.14 12.0 0.0 0.24 11.2 0.0 1.4 1 0 0 1 1 1 0 Xylanase inhibitor C-terminal DEP PF00610.21 ELR24719.1 - 7.3e-14 51.6 0.1 2.9e-09 36.9 0.0 2.3 2 0 0 2 2 2 2 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) Myosin_head PF00063.21 ELR24720.1 - 2e-264 879.0 0.2 2.5e-264 878.7 0.2 1.1 1 0 0 1 1 1 1 Myosin head (motor domain) Myosin_TH1 PF06017.13 ELR24720.1 - 1e-39 136.2 0.9 2e-39 135.2 0.9 1.5 1 0 0 1 1 1 1 Unconventional myosin tail, actin- and lipid-binding SH3_9 PF14604.6 ELR24720.1 - 5.4e-19 67.8 0.1 1.5e-18 66.3 0.1 1.9 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 ELR24720.1 - 7.1e-18 64.0 0.1 1.4e-17 63.0 0.1 1.5 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 ELR24720.1 - 5.4e-13 48.4 0.0 1.5e-12 47.0 0.0 1.8 1 0 0 1 1 1 1 Variant SH3 domain RsgA_GTPase PF03193.16 ELR24720.1 - 0.025 14.5 0.0 0.043 13.7 0.0 1.3 1 0 0 1 1 1 0 RsgA GTPase AAA_16 PF13191.6 ELR24720.1 - 0.03 14.7 0.0 0.081 13.3 0.0 1.7 1 0 0 1 1 1 0 AAA ATPase domain AAA_22 PF13401.6 ELR24720.1 - 0.091 13.0 0.0 0.44 10.8 0.0 2.1 2 0 0 2 2 2 0 AAA domain Zeta_toxin PF06414.12 ELR24720.1 - 0.099 11.9 0.0 0.19 11.0 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin RNA_helicase PF00910.22 ELR24720.1 - 0.17 12.3 0.1 2.7 8.4 0.0 3.1 3 0 0 3 3 3 0 RNA helicase AAA_30 PF13604.6 ELR24720.1 - 0.23 11.1 0.0 0.5 10.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain CTP_transf_like PF01467.26 ELR24721.1 - 3.1e-29 102.0 0.0 3.7e-29 101.7 0.0 1.1 1 0 0 1 1 1 1 Cytidylyltransferase-like Mito_carr PF00153.27 ELR24722.1 - 5.3e-39 132.1 6.0 8.7e-14 51.2 0.0 3.3 3 1 0 3 3 3 3 Mitochondrial carrier protein Mito_carr PF00153.27 ELR24723.1 - 1.1e-61 204.8 5.0 3.4e-25 87.8 0.2 3.5 4 0 0 4 4 4 3 Mitochondrial carrier protein Pkinase PF00069.25 ELR24724.1 - 3e-60 203.8 0.0 3.9e-60 203.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR24724.1 - 4.5e-42 144.1 0.0 6.6e-42 143.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 ELR24724.1 - 1.9e-05 23.6 0.0 2.8e-05 23.1 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 ELR24724.1 - 0.011 15.1 0.1 0.023 14.0 0.1 1.5 1 1 0 1 1 1 0 Kinase-like Kdo PF06293.14 ELR24724.1 - 0.036 13.4 0.0 0.066 12.6 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family PEP_mutase PF13714.6 ELR24725.1 - 1.8e-47 161.8 1.2 2.7e-47 161.2 1.2 1.3 1 0 0 1 1 1 1 Phosphoenolpyruvate phosphomutase ICL PF00463.21 ELR24725.1 - 1.8e-15 56.5 0.4 2.8e-15 55.8 0.4 1.3 1 0 0 1 1 1 1 Isocitrate lyase family RNA_pol_3_Rpc31 PF11705.8 ELR24725.1 - 0.077 13.2 17.8 0.16 12.2 17.8 1.5 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 DUF4045 PF13254.6 ELR24725.1 - 0.28 10.8 9.0 0.39 10.3 9.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) RR_TM4-6 PF06459.12 ELR24725.1 - 0.48 10.2 10.4 0.7 9.7 10.4 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF4746 PF15928.5 ELR24725.1 - 0.89 8.9 13.3 1.4 8.2 13.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) SAPS PF04499.15 ELR24725.1 - 1.4 7.6 6.9 1.6 7.4 6.9 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein CDC27 PF09507.10 ELR24725.1 - 1.6 8.0 20.6 2.4 7.5 20.6 1.2 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 BUD22 PF09073.10 ELR24725.1 - 2.3 7.5 22.3 3.4 6.9 22.3 1.1 1 0 0 1 1 1 0 BUD22 DUF913 PF06025.12 ELR24725.1 - 3.4 6.5 4.9 5.1 6.0 4.9 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) RhoGEF67_u2 PF16614.5 ELR24726.1 - 0.026 14.6 0.4 0.039 14.0 0.4 1.3 1 0 0 1 1 1 0 Unstructured region two on RhoGEF 6 and 7 AP3D1 PF06375.11 ELR24726.1 - 0.077 13.2 0.3 0.11 12.7 0.3 1.3 1 1 0 1 1 1 0 AP-3 complex subunit delta-1 Abhydrolase_6 PF12697.7 ELR24727.1 - 1.4e-14 55.2 9.2 2.2e-14 54.6 9.2 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 ELR24727.1 - 5.9e-07 29.0 0.0 8.9e-07 28.4 0.0 1.4 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 ELR24727.1 - 1.7e-06 27.8 0.0 3e-06 27.1 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Thioesterase PF00975.20 ELR24727.1 - 0.0032 17.6 0.0 0.0062 16.7 0.0 1.7 1 1 0 1 1 1 1 Thioesterase domain Mob1_phocein PF03637.17 ELR24728.1 - 7.2e-82 273.4 0.1 8.5e-82 273.2 0.1 1.1 1 0 0 1 1 1 1 Mob1/phocein family Adaptin_N PF01602.20 ELR24729.1 - 4.3e-88 296.1 0.0 6e-88 295.7 0.0 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 ELR24729.1 - 1.7e-32 112.7 0.0 1.2e-31 110.0 0.0 2.2 2 0 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1 B2-adapt-app_C PF09066.10 ELR24729.1 - 2e-16 60.1 0.0 4.8e-16 58.8 0.0 1.7 1 0 0 1 1 1 1 Beta2-adaptin appendage, C-terminal sub-domain HEAT_2 PF13646.6 ELR24729.1 - 7.3e-07 29.5 10.7 0.0027 18.0 0.6 5.5 4 2 2 6 6 6 2 HEAT repeats HEAT PF02985.22 ELR24729.1 - 3e-05 23.9 6.8 0.012 15.8 0.0 5.9 7 0 0 7 7 7 1 HEAT repeat HEAT_EZ PF13513.6 ELR24729.1 - 0.16 12.5 15.1 0.48 11.0 0.0 5.8 5 1 1 6 6 6 0 HEAT-like repeat UCH PF00443.29 ELR24731.1 - 1.3e-34 119.9 0.0 1.5e-34 119.6 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 ELR24731.1 - 0.016 14.8 0.1 0.27 10.8 0.0 2.5 2 1 0 2 2 2 0 Ubiquitin carboxyl-terminal hydrolase Arm-DNA-bind_5 PF17293.2 ELR24731.1 - 0.12 12.8 0.1 0.26 11.8 0.1 1.4 1 0 0 1 1 1 0 Arm DNA-binding domain RasGEF_N PF00618.20 ELR24732.1 - 3e-10 40.2 0.0 9.1e-10 38.7 0.0 1.8 1 0 0 1 1 1 1 RasGEF N-terminal motif F-box-like PF12937.7 ELR24732.1 - 7.5e-10 38.6 1.9 7.5e-10 38.6 1.9 2.0 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 ELR24732.1 - 7.4e-09 35.3 3.2 1.5e-08 34.3 3.2 1.6 1 0 0 1 1 1 1 F-box domain zf-RanBP PF00641.18 ELR24732.1 - 0.22 10.8 4.3 0.43 9.9 4.3 1.4 1 0 0 1 1 1 0 Zn-finger in Ran binding protein and others RasGEF PF00617.19 ELR24733.1 - 4.1e-55 186.7 0.1 5.8e-55 186.2 0.1 1.1 1 0 0 1 1 1 1 RasGEF domain K_oxygenase PF13434.6 ELR24733.1 - 0.096 11.8 0.1 0.15 11.2 0.1 1.2 1 0 0 1 1 1 0 L-lysine 6-monooxygenase (NADPH-requiring) DSPc PF00782.20 ELR24735.1 - 3.1e-14 52.9 0.0 3.4e-14 52.8 0.0 1.1 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 ELR24735.1 - 4.6e-09 36.2 0.0 6.5e-09 35.7 0.0 1.1 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.6 ELR24735.1 - 2.3e-06 27.7 0.2 5.7e-06 26.5 0.2 1.7 1 1 0 1 1 1 1 Tyrosine phosphatase family PTPlike_phytase PF14566.6 ELR24735.1 - 3.7e-05 23.9 0.0 5.6e-05 23.3 0.0 1.2 1 0 0 1 1 1 1 Inositol hexakisphosphate SH3_9 PF14604.6 ELR24736.1 - 4.4e-13 48.9 0.2 1.1e-12 47.6 0.2 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 ELR24736.1 - 7e-11 41.6 2.8 8.2e-11 41.3 0.5 2.2 2 0 0 2 2 2 1 SH3 domain SH3_2 PF07653.17 ELR24736.1 - 4.5e-06 26.3 0.4 1.1e-05 25.0 0.4 1.6 1 0 0 1 1 1 1 Variant SH3 domain AAA_23 PF13476.6 ELR24736.1 - 0.074 13.5 16.7 0.25 11.8 16.7 2.0 1 0 0 1 1 1 0 AAA domain DUF4094 PF13334.6 ELR24736.1 - 9.5 6.7 15.0 22 5.6 10.8 2.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4094) XPG_I PF00867.18 ELR24737.1 - 8.3e-24 83.8 0.0 1.7e-23 82.8 0.0 1.5 1 0 0 1 1 1 1 XPG I-region XPG_N PF00752.17 ELR24737.1 - 4.9e-06 26.9 0.1 6.1e-05 23.4 0.0 2.3 1 1 1 2 2 2 1 XPG N-terminal domain XPG_I_2 PF12813.7 ELR24737.1 - 0.0061 16.1 0.0 0.016 14.7 0.0 1.7 1 0 0 1 1 1 1 XPG domain containing TPR_2 PF07719.17 ELR24737.1 - 0.067 13.3 0.1 0.18 12.0 0.1 1.7 1 0 0 1 1 1 0 Tetratricopeptide repeat Mucin PF01456.17 ELR24737.1 - 0.096 12.7 13.8 0.26 11.3 13.8 1.7 1 0 0 1 1 1 0 Mucin-like glycoprotein PAPA-1 PF04795.12 ELR24737.1 - 6.9 7.5 8.7 1.7 9.5 3.9 2.5 2 0 0 2 2 2 0 PAPA-1-like conserved region Abhydrolase_6 PF12697.7 ELR24738.1 - 2.6e-14 54.4 2.1 2.6e-14 54.4 2.1 1.9 2 0 0 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 ELR24738.1 - 3.6e-12 46.5 0.2 7.5e-09 35.6 0.0 2.8 3 0 0 3 3 3 2 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 ELR24738.1 - 1e-10 41.3 0.0 1.6e-10 40.7 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Thioesterase PF00975.20 ELR24738.1 - 0.00018 21.7 0.0 0.00043 20.5 0.0 1.6 1 0 0 1 1 1 1 Thioesterase domain UPF0227 PF05728.12 ELR24738.1 - 0.003 17.5 0.0 0.0071 16.3 0.0 1.6 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0227) Abhydrolase_2 PF02230.16 ELR24738.1 - 0.016 15.0 0.1 0.91 9.3 0.0 2.8 2 1 1 3 3 3 0 Phospholipase/Carboxylesterase MarC PF01914.17 ELR24738.1 - 0.055 12.8 0.0 0.27 10.6 0.0 2.0 2 0 0 2 2 2 0 MarC family integral membrane protein FYVE PF01363.21 ELR24738.1 - 0.39 10.9 3.1 1.9 8.7 3.1 2.0 1 1 0 1 1 1 0 FYVE zinc finger Aldedh PF00171.22 ELR24739.1 - 1.3e-128 429.4 0.2 1.6e-128 429.1 0.2 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family OTU PF02338.19 ELR24740.1 - 1.2e-22 80.7 0.0 3e-22 79.5 0.0 1.6 2 0 0 2 2 2 1 OTU-like cysteine protease Peptidase_C65 PF10275.9 ELR24740.1 - 4.9e-05 22.9 0.0 0.018 14.5 0.0 2.5 2 1 1 3 3 3 2 Peptidase C65 Otubain ATG16 PF08614.11 ELR24740.1 - 6.2 7.0 23.3 0.49 10.6 16.2 2.4 2 1 0 2 2 2 0 Autophagy protein 16 (ATG16) Metallophos PF00149.28 ELR24741.1 - 6.6e-41 141.1 0.1 8.4e-41 140.7 0.1 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 ELR24741.1 - 2.3e-22 79.1 1.4 4.6e-22 78.2 0.9 1.8 2 0 0 2 2 2 1 Serine-threonine protein phosphatase N-terminal domain RhoGAP PF00620.27 ELR24743.1 - 1.6e-40 138.4 0.0 4.2e-40 137.1 0.0 1.7 1 0 0 1 1 1 1 RhoGAP domain DTHCT PF08070.11 ELR24743.1 - 0.0026 18.4 19.8 0.0026 18.4 19.8 5.9 2 1 4 6 6 6 1 DTHCT (NUC029) region Ank_2 PF12796.7 ELR24744.1 - 1.6e-80 265.7 17.7 3.5e-12 46.7 0.0 9.5 5 5 6 11 11 11 10 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ELR24744.1 - 1.7e-67 223.0 15.7 9.3e-11 42.0 0.0 13.3 7 6 6 13 13 13 13 Ankyrin repeats (many copies) Ank_5 PF13857.6 ELR24744.1 - 1.9e-66 219.2 18.8 9.4e-08 32.2 0.0 12.4 7 5 5 12 12 12 12 Ankyrin repeats (many copies) Ank_3 PF13606.6 ELR24744.1 - 3e-59 190.0 9.7 0.00011 22.3 0.0 16.8 17 0 0 17 17 17 12 Ankyrin repeat Ank PF00023.30 ELR24744.1 - 2.5e-39 132.0 23.2 0.0054 17.1 0.0 16.4 16 1 1 17 17 17 12 Ankyrin repeat Pkinase PF00069.25 ELR24746.1 - 1.7e-63 214.5 0.0 1.7e-63 214.5 0.0 1.7 2 0 0 2 2 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR24746.1 - 1.6e-52 178.3 0.0 2.9e-52 177.5 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kelch_4 PF13418.6 ELR24746.1 - 6.9e-39 131.6 8.8 5.1e-07 29.6 0.0 6.5 6 0 0 6 6 6 6 Galactose oxidase, central domain Kelch_6 PF13964.6 ELR24746.1 - 2.8e-29 100.4 6.5 5.6e-06 26.5 0.1 6.4 5 1 1 6 6 6 5 Kelch motif Kelch_1 PF01344.25 ELR24746.1 - 1e-28 98.6 7.4 7.2e-10 38.3 1.2 6.3 6 0 0 6 6 6 3 Kelch motif Kelch_3 PF13415.6 ELR24746.1 - 3.2e-28 97.4 19.3 1.5e-08 34.7 0.3 6.9 7 0 0 7 7 6 4 Galactose oxidase, central domain Kelch_5 PF13854.6 ELR24746.1 - 1.7e-22 78.9 8.1 3.3e-06 26.9 0.1 6.5 6 0 0 6 6 6 3 Kelch motif Kelch_2 PF07646.15 ELR24746.1 - 2.7e-20 71.5 10.2 3.3e-05 23.7 0.2 5.7 5 0 0 5 5 5 4 Kelch motif Pkinase_fungal PF17667.1 ELR24746.1 - 8.9e-05 21.4 2.9 8.9e-05 21.4 2.9 2.8 2 1 0 2 2 2 1 Fungal protein kinase AAA_23 PF13476.6 ELR24746.1 - 0.012 16.1 7.6 0.97 9.9 0.3 2.6 3 0 0 3 3 2 0 AAA domain Seadorna_VP7 PF07387.11 ELR24746.1 - 0.048 12.7 0.1 0.078 12.0 0.1 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 AAA_11 PF13086.6 ELR24746.1 - 0.16 11.7 5.2 2.9 7.6 1.6 2.2 2 0 0 2 2 2 0 AAA domain RNA_polI_A34 PF08208.11 ELR24746.1 - 0.25 11.4 33.8 0.18 11.9 6.0 2.6 2 0 0 2 2 2 0 DNA-directed RNA polymerase I subunit RPA34.5 DDHD PF02862.17 ELR24746.1 - 0.37 10.9 3.2 9.8 6.3 1.5 2.4 2 0 0 2 2 2 0 DDHD domain PQQ_3 PF13570.6 ELR24746.1 - 0.43 11.1 11.2 2.1 9.0 1.0 4.3 4 0 0 4 4 3 0 PQQ-like domain U1snRNP70_N PF12220.8 ELR24746.1 - 0.8 10.4 15.2 1.6 9.5 1.3 2.8 2 0 0 2 2 2 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal CPSF100_C PF13299.6 ELR24746.1 - 1 9.5 12.7 3.8 7.7 0.6 2.6 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal RR_TM4-6 PF06459.12 ELR24746.1 - 1.3 8.8 17.4 1.6 8.5 0.7 2.3 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 SR-25 PF10500.9 ELR24746.1 - 1.7 8.2 32.9 5.8 6.5 10.0 2.9 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein Mito_fiss_reg PF05308.11 ELR24746.1 - 7 6.7 24.9 0.052 13.6 7.3 3.1 2 1 1 3 3 2 0 Mitochondrial fission regulator Vfa1 PF08432.10 ELR24746.1 - 10 6.4 24.6 5 7.4 4.4 2.5 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 BTB_2 PF02214.22 ELR24748.1 - 5e-21 74.9 0.0 9.5e-21 74.0 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain WD40 PF00400.32 ELR24748.1 - 0.00076 20.2 8.3 0.0099 16.7 0.3 3.5 3 1 0 3 3 3 2 WD domain, G-beta repeat BTB PF00651.31 ELR24748.1 - 0.0053 17.0 0.0 0.012 15.8 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain BTB_3 PF16017.5 ELR24748.1 - 0.075 13.1 0.0 0.15 12.2 0.0 1.5 1 0 0 1 1 1 0 BTB/POZ domain Hormone_3 PF00159.18 ELR24748.1 - 0.077 13.1 0.0 0.18 11.9 0.0 1.6 1 0 0 1 1 1 0 Pancreatic hormone peptide ANAPC4_WD40 PF12894.7 ELR24748.1 - 0.13 12.5 0.1 3 8.2 0.0 3.0 3 1 1 4 4 4 0 Anaphase-promoting complex subunit 4 WD40 domain V-SNARE_C PF12352.8 ELR24749.1 - 4.4e-17 62.1 1.6 6.9e-17 61.5 0.6 1.8 1 1 1 2 2 2 1 Snare region anchored in the vesicle membrane C-terminus Sec20 PF03908.13 ELR24749.1 - 5.8e-06 26.1 0.1 9e-06 25.5 0.1 1.3 1 0 0 1 1 1 1 Sec20 FtsX PF02687.21 ELR24749.1 - 0.1 13.1 1.3 0.14 12.6 1.3 1.2 1 0 0 1 1 1 0 FtsX-like permease family DUF4366 PF14283.6 ELR24749.1 - 0.17 12.0 2.2 0.26 11.3 2.2 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4366) Abhydrolase_1 PF00561.20 ELR24750.1 - 2.6e-25 89.5 0.1 3.5e-24 85.8 0.1 2.2 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 ELR24750.1 - 8.7e-17 62.5 6.8 8.7e-17 62.5 6.8 1.9 2 0 0 2 2 2 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 ELR24750.1 - 1.3e-13 50.8 0.0 3.8e-12 46.0 0.0 2.2 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Peptidase_S9 PF00326.21 ELR24750.1 - 0.0037 16.8 0.0 0.015 14.8 0.0 1.9 2 0 0 2 2 2 1 Prolyl oligopeptidase family BAAT_C PF08840.11 ELR24750.1 - 0.064 13.2 0.0 8.4 6.2 0.0 2.3 2 0 0 2 2 2 0 BAAT / Acyl-CoA thioester hydrolase C terminal Abhydrolase_3 PF07859.13 ELR24750.1 - 0.068 13.0 0.0 0.15 11.9 0.0 1.6 1 0 0 1 1 1 0 alpha/beta hydrolase fold Pkinase_Tyr PF07714.17 ELR24751.1 - 2.7e-61 207.1 0.0 3.7e-61 206.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ELR24751.1 - 3.9e-55 187.1 0.0 6.3e-55 186.4 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain SH2 PF00017.24 ELR24751.1 - 2.1e-14 53.4 0.1 3.9e-14 52.5 0.1 1.5 1 0 0 1 1 1 1 SH2 domain APH PF01636.23 ELR24751.1 - 0.006 16.5 0.2 0.44 10.4 0.1 2.3 1 1 1 2 2 2 2 Phosphotransferase enzyme family Cbl_N3 PF02762.14 ELR24751.1 - 0.2 11.5 0.0 0.42 10.5 0.0 1.5 1 0 0 1 1 1 0 CBL proto-oncogene N-terminus, SH2-like domain PaREP1 PF05942.11 ELR24752.1 - 0.013 15.4 0.1 0.02 14.8 0.1 1.3 1 0 0 1 1 1 0 Archaeal PaREP1/PaREP8 family Abhydrolase_7 PF12715.7 ELR24753.1 - 0.26 10.5 0.0 0.4 9.9 0.0 1.2 1 0 0 1 1 1 0 Abhydrolase family PTPRCAP PF15713.5 ELR24753.1 - 0.27 11.5 7.6 1.8 8.8 0.9 2.3 2 0 0 2 2 2 0 Protein tyrosine phosphatase receptor type C-associated DnaJ_C PF01556.18 ELR24754.1 - 1.8e-36 125.4 0.0 2.5e-36 125.0 0.0 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 ELR24754.1 - 2.6e-28 97.9 0.4 5.8e-28 96.8 0.4 1.7 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.19 ELR24754.1 - 8.8e-12 45.2 18.1 1.6e-11 44.4 18.1 1.4 1 0 0 1 1 1 1 DnaJ central domain Anti-TRAP PF15777.5 ELR24754.1 - 0.0026 17.7 14.1 0.047 13.7 2.5 2.5 2 0 0 2 2 2 2 Tryptophan RNA-binding attenuator protein inhibitory protein HypA PF01155.19 ELR24754.1 - 0.18 11.9 7.3 2.2 8.4 1.3 2.3 2 0 0 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-RING_10 PF16685.5 ELR24754.1 - 4.6 7.5 8.8 0.34 11.1 1.0 2.2 1 1 0 2 2 2 0 zinc RING finger of MSL2 zinc-ribbons_6 PF07191.12 ELR24754.1 - 4.7 7.3 8.7 13 5.9 8.7 1.7 1 1 0 1 1 1 0 zinc-ribbons RRP7 PF12923.7 ELR24755.1 - 3.7e-31 107.7 5.4 3.7e-31 107.7 5.4 2.5 2 1 1 3 3 3 1 Ribosomal RNA-processing protein 7 (RRP7) C-terminal domain Limkain-b1 PF11608.8 ELR24755.1 - 0.0067 16.5 0.0 0.016 15.3 0.0 1.6 1 0 0 1 1 1 1 Limkain b1 DUF4719 PF15843.5 ELR24755.1 - 4.3 7.4 6.5 48 4.0 5.2 2.9 2 1 0 2 2 2 0 Domain of unknown function (DUF4719) MRP-L20 PF12824.7 ELR24756.1 - 1.7e-12 47.8 0.0 4e-12 46.6 0.0 1.6 1 0 0 1 1 1 1 Mitochondrial ribosomal protein subunit L20 Neugrin PF06413.11 ELR24756.1 - 0.022 14.8 1.0 0.055 13.5 0.9 1.8 1 1 0 1 1 1 0 Neugrin HTH_32 PF13565.6 ELR24756.1 - 0.36 11.5 14.1 0.087 13.4 2.6 3.4 1 1 2 3 3 3 0 Homeodomain-like domain GST_C_3 PF14497.6 ELR24757.1 - 4.4e-20 71.7 0.0 9.2e-20 70.7 0.0 1.5 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 ELR24757.1 - 3.9e-07 30.2 0.0 6.9e-07 29.4 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 ELR24757.1 - 5.5e-05 23.4 0.0 0.00017 21.9 0.0 1.9 1 1 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 ELR24757.1 - 0.065 13.3 0.0 0.16 12.0 0.0 1.7 1 1 0 1 1 1 0 Glutathione S-transferase, C-terminal domain Methyltransf_16 PF10294.9 ELR24758.1 - 1.4e-18 67.3 0.1 3e-16 59.7 0.0 2.3 2 1 0 2 2 2 2 Lysine methyltransferase NAPRTase_N PF17767.1 ELR24759.1 - 1.1e-38 132.5 0.0 2.5e-38 131.3 0.0 1.7 2 0 0 2 2 2 1 Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain NAPRTase_C PF17956.1 ELR24759.1 - 3.9e-36 123.9 0.0 6.5e-36 123.1 0.0 1.4 1 0 0 1 1 1 1 Nicotinate phosphoribosyltransferase C-terminal domain NAPRTase PF04095.16 ELR24759.1 - 0.00023 20.8 0.0 0.00037 20.2 0.0 1.2 1 0 0 1 1 1 1 Nicotinate phosphoribosyltransferase (NAPRTase) family Melibiase_2 PF16499.5 ELR24760.1 - 6.1e-74 248.7 7.3 1e-73 248.0 7.3 1.3 1 1 0 1 1 1 1 Alpha galactosidase A Melibiase_C PF17801.1 ELR24760.1 - 3.3e-17 62.3 0.2 9.2e-17 60.9 0.1 1.8 2 0 0 2 2 2 1 Alpha galactosidase C-terminal beta sandwich domain Melibiase PF02065.18 ELR24760.1 - 1.3e-05 24.4 0.6 3.6e-05 22.9 0.0 1.8 2 0 0 2 2 2 1 Melibiase Melibiase_2_C PF17450.2 ELR24760.1 - 0.00016 21.8 0.0 0.00027 21.1 0.0 1.4 1 0 0 1 1 1 1 Alpha galactosidase A C-terminal beta sandwich domain RFX_DNA_binding PF02257.15 ELR24761.1 - 1.4e-13 51.3 0.0 1.4e-13 51.3 0.0 1.9 2 0 0 2 2 2 1 RFX DNA-binding domain Pox_D5 PF03288.16 ELR24761.1 - 1e-05 25.9 0.1 5.6e-05 23.5 0.0 2.1 2 0 0 2 2 2 1 Poxvirus D5 protein-like RabGAP-TBC PF00566.18 ELR24762.1 - 3.7e-51 173.8 0.1 3.7e-51 173.8 0.1 3.1 4 0 0 4 4 4 1 Rab-GTPase-TBC domain GRAM PF02893.20 ELR24762.1 - 1.1e-13 51.0 0.0 9.3e-07 28.7 0.0 2.4 2 0 0 2 2 2 2 GRAM domain Rab5ip PF07019.12 ELR24763.1 - 3.7e-09 37.0 4.7 9.2e-09 35.8 4.7 1.7 1 1 0 1 1 1 1 Rab5-interacting protein (Rab5ip) Rho_GDI PF02115.17 ELR24764.1 - 6.9e-59 198.9 0.0 7.5e-59 198.8 0.0 1.0 1 0 0 1 1 1 1 RHO protein GDP dissociation inhibitor IBR PF01485.21 ELR24765.1 - 5.1e-18 65.1 45.9 6.4e-10 39.1 8.6 4.6 3 1 1 4 4 4 2 IBR domain, a half RING-finger domain zf-C3HC4_2 PF13923.6 ELR24765.1 - 1.2e-07 31.5 3.1 1.2e-07 31.5 3.1 6.0 4 2 1 5 5 5 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 ELR24765.1 - 2.2e-05 24.2 6.7 2.2e-05 24.2 6.7 4.4 4 0 0 4 4 4 2 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 ELR24765.1 - 3.3e-05 24.1 3.8 3.3e-05 24.1 3.8 5.2 2 2 2 4 4 4 1 Ring finger domain zf-RING_UBOX PF13445.6 ELR24765.1 - 0.00024 21.0 0.9 0.00024 21.0 0.9 5.0 3 2 0 3 3 3 1 RING-type zinc-finger zf-C3HC4 PF00097.25 ELR24765.1 - 0.00035 20.4 8.7 0.00035 20.4 8.7 4.9 3 2 1 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 ELR24765.1 - 0.00044 19.9 2.1 0.0021 17.8 2.1 2.3 1 0 0 1 1 1 1 RING-like zinc finger zf-RING_5 PF14634.6 ELR24765.1 - 0.0015 18.4 7.2 0.0015 18.4 7.2 4.0 2 1 1 3 3 3 1 zinc-RING finger domain UBA_4 PF14555.6 ELR24765.1 - 0.063 13.1 0.0 0.45 10.4 0.0 2.2 2 0 0 2 2 2 0 UBA-like domain zf-RING_4 PF14570.6 ELR24765.1 - 6.7 6.6 41.3 1.1 9.0 7.6 4.7 4 0 0 4 4 4 0 RING/Ubox like zinc-binding domain tRNA-synt_2 PF00152.20 ELR24766.1 - 8.2e-76 255.1 0.0 1.1e-75 254.7 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 ELR24766.1 - 2.4e-08 33.8 0.1 5.3e-08 32.7 0.1 1.5 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.20 ELR24766.1 - 0.047 13.2 0.1 0.25 10.8 0.0 1.9 2 0 0 2 2 2 0 tRNA synthetases class II core domain (F) Desulfoferrodox PF01880.18 ELR24766.1 - 0.087 13.4 0.0 0.2 12.2 0.0 1.6 1 0 0 1 1 1 0 Desulfoferrodoxin Seryl_tRNA_N PF02403.22 ELR24769.1 - 0.018 15.3 3.1 0.022 15.0 2.1 1.7 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain Rhodopsin_N PF10413.9 ELR24770.1 - 0.011 15.5 0.0 0.023 14.5 0.0 1.5 1 0 0 1 1 1 0 Amino terminal of the G-protein receptor rhodopsin DUF3586 PF12131.8 ELR24770.1 - 0.066 13.4 1.0 0.066 13.4 1.0 3.2 1 1 2 3 3 3 0 Protein of unknown function (DUF3586) Methyltr_RsmB-F PF01189.17 ELR24771.1 - 1.8e-65 220.3 0.0 4.6e-65 219.0 0.0 1.7 1 1 0 1 1 1 1 16S rRNA methyltransferase RsmB/F Methyltr_RsmF_N PF17125.5 ELR24771.1 - 7.4e-08 32.8 0.0 1.9e-07 31.5 0.0 1.7 1 0 0 1 1 1 1 N-terminal domain of 16S rRNA methyltransferase RsmF PCMT PF01135.19 ELR24771.1 - 7.7e-05 22.5 0.0 0.00018 21.3 0.0 1.6 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) FtsJ PF01728.19 ELR24771.1 - 0.00044 20.4 0.0 0.0011 19.1 0.0 1.6 2 0 0 2 2 2 1 FtsJ-like methyltransferase Met_10 PF02475.16 ELR24771.1 - 0.0029 17.4 0.0 0.0053 16.5 0.0 1.3 1 0 0 1 1 1 1 Met-10+ like-protein GCD14 PF08704.10 ELR24771.1 - 0.07 12.8 0.0 0.07 12.8 0.0 2.9 2 1 0 3 3 3 0 tRNA methyltransferase complex GCD14 subunit Hydrolase_6 PF13344.6 ELR24771.1 - 0.081 13.0 0.2 8.8 6.5 0.0 2.9 3 0 0 3 3 3 0 Haloacid dehalogenase-like hydrolase Adap_comp_sub PF00928.21 ELR24772.1 - 2e-89 299.5 0.0 2.5e-89 299.1 0.0 1.1 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 ELR24772.1 - 1.6e-09 37.8 3.5 3.1e-09 36.9 3.5 1.4 1 0 0 1 1 1 1 Clathrin adaptor complex small chain Actin PF00022.19 ELR24773.1 - 4.6e-115 384.5 0.0 4e-114 381.4 0.0 1.9 1 1 0 1 1 1 1 Actin DENN PF02141.21 ELR24775.1 - 7.2e-50 169.5 2.7 7.2e-50 169.5 2.7 1.9 2 0 0 2 2 2 1 DENN (AEX-3) domain DUF547 PF04784.14 ELR24775.1 - 3.6e-29 101.3 0.0 7.4e-29 100.3 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function, DUF547 uDENN PF03456.18 ELR24775.1 - 5.4e-10 39.9 0.3 2.8e-09 37.6 0.2 2.3 2 0 0 2 2 2 1 uDENN domain dDENN PF03455.19 ELR24775.1 - 0.00031 20.7 1.2 0.0012 18.7 1.2 2.2 1 0 0 1 1 1 1 dDENN domain NARP1 PF12569.8 ELR24775.1 - 0.12 11.3 0.0 0.24 10.3 0.0 1.4 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 Bacteriocin_IIi PF11758.8 ELR24776.1 - 0.099 12.5 2.2 5.6 6.9 0.4 2.3 1 1 1 2 2 2 0 Aureocin-like type II bacteriocin KxDL PF10241.9 ELR24776.1 - 0.11 12.8 1.8 1.2 9.5 0.4 2.6 1 1 1 2 2 2 0 Uncharacterized conserved protein DUF4709 PF15821.5 ELR24776.1 - 0.22 11.8 2.4 0.52 10.6 0.3 2.3 2 1 0 2 2 2 0 Domain of unknown function (DUF4709) Methyltransf_23 PF13489.6 ELR24777.1 - 2.1e-12 47.2 0.2 1.9e-05 24.5 0.0 2.1 1 1 1 2 2 2 2 Methyltransferase domain Methyltransf_25 PF13649.6 ELR24777.1 - 8.5e-07 29.6 0.0 1.7e-06 28.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ELR24777.1 - 0.00033 21.2 0.0 0.00067 20.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ELR24777.1 - 0.00042 21.0 0.0 0.00079 20.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 ELR24777.1 - 0.044 13.1 0.0 0.07 12.5 0.0 1.3 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family Methyltransf_31 PF13847.6 ELR24777.1 - 0.2 11.4 0.0 0.37 10.6 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain F-box-like PF12937.7 ELR24778.1 - 8.7e-09 35.1 0.1 1.6e-08 34.3 0.1 1.5 1 0 0 1 1 1 1 F-box-like Arrestin_C PF02752.22 ELR24778.1 - 1.1e-05 25.9 0.0 2.9e-05 24.5 0.0 1.6 1 0 0 1 1 1 1 Arrestin (or S-antigen), C-terminal domain CDC45 PF02724.14 ELR24778.1 - 0.026 12.9 2.3 0.045 12.0 2.3 1.5 1 0 0 1 1 1 0 CDC45-like protein DUF4611 PF15387.6 ELR24778.1 - 0.57 10.4 0.1 0.57 10.4 0.1 2.9 2 1 1 3 3 3 0 Domain of unknown function (DUF4611) Pkinase_Tyr PF07714.17 ELR24779.1 - 2.1e-66 223.9 0.0 4.7e-66 222.7 0.0 1.6 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ELR24779.1 - 1.9e-48 165.2 0.0 3.2e-48 164.4 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_fungal PF17667.1 ELR24779.1 - 3.7e-06 26.0 0.8 9.1e-05 21.4 0.0 2.2 2 0 0 2 2 2 1 Fungal protein kinase Kinase-like PF14531.6 ELR24779.1 - 0.025 13.9 0.1 0.052 12.9 0.0 1.5 2 0 0 2 2 2 0 Kinase-like APH PF01636.23 ELR24779.1 - 0.32 10.9 2.6 5.9 6.7 0.3 3.2 3 1 1 4 4 4 0 Phosphotransferase enzyme family SPX PF03105.19 ELR24779.1 - 1.1 9.1 14.2 1.7 8.5 14.2 1.3 1 0 0 1 1 1 0 SPX domain Apt1 PF10351.9 ELR24779.1 - 5.5 5.7 12.9 8.5 5.1 12.9 1.4 1 0 0 1 1 1 0 Golgi-body localisation protein domain Tmemb_cc2 PF10267.9 ELR24779.1 - 9.3 5.3 11.4 18 4.3 11.5 1.4 1 1 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein NDK PF00334.19 ELR24780.1 - 1.8e-23 83.1 0.0 1.6e-13 50.8 0.0 3.7 3 1 0 4 4 4 3 Nucleoside diphosphate kinase DAGK_acc PF00609.19 ELR24781.1 - 2.5e-37 128.7 0.0 4.7e-37 127.8 0.0 1.4 1 0 0 1 1 1 1 Diacylglycerol kinase accessory domain DAGK_cat PF00781.24 ELR24781.1 - 9.8e-23 80.1 0.0 1.9e-22 79.2 0.0 1.5 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain C1_1 PF00130.22 ELR24781.1 - 1.2e-15 57.1 18.1 8.9e-10 38.3 7.3 2.4 2 0 0 2 2 2 2 Phorbol esters/diacylglycerol binding domain (C1 domain) C1_2 PF03107.16 ELR24781.1 - 0.0078 16.5 2.1 0.0078 16.5 2.1 3.0 2 1 1 3 3 3 1 C1 domain Prok-RING_1 PF14446.6 ELR24781.1 - 0.5 10.3 17.3 3 7.8 6.1 2.6 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 FYVE_2 PF02318.16 ELR24781.1 - 0.82 9.9 6.2 0.22 11.8 2.8 1.8 1 1 0 1 1 1 0 FYVE-type zinc finger Ribosomal_S13_N PF08069.12 ELR24782.1 - 1.1e-30 105.4 0.1 2e-30 104.6 0.1 1.5 1 0 0 1 1 1 1 Ribosomal S13/S15 N-terminal domain Ribosomal_S15 PF00312.22 ELR24782.1 - 2e-14 53.6 0.8 2.8e-14 53.1 0.8 1.2 1 0 0 1 1 1 1 Ribosomal protein S15 LMP PF04778.12 ELR24782.1 - 0.016 15.1 0.1 0.022 14.7 0.1 1.2 1 0 0 1 1 1 0 LMP repeated region zf-CCHC PF00098.23 ELR24783.1 - 1e-34 117.0 51.3 2.8e-07 30.3 2.6 6.4 5 1 1 6 6 6 6 Zinc knuckle zf-CCHC_4 PF14392.6 ELR24783.1 - 5.9e-05 22.7 34.0 0.32 10.8 0.4 6.2 5 1 1 6 6 6 5 Zinc knuckle zf-CCHC_5 PF14787.6 ELR24783.1 - 0.0022 17.7 40.3 0.86 9.4 2.5 6.2 4 1 2 6 6 6 5 GAG-polyprotein viral zinc-finger zf-CCHC_3 PF13917.6 ELR24783.1 - 0.0077 16.2 32.1 0.73 9.8 0.6 5.5 2 2 3 5 5 5 4 Zinc knuckle TRAF6_Z2 PF18048.1 ELR24783.1 - 0.12 12.4 4.8 7.9 6.7 0.3 3.8 4 0 0 4 4 4 0 TNF receptor-associated factor 6 zinc finger 2 DnaJ_CXXCXGXG PF00684.19 ELR24783.1 - 1.5 9.3 29.7 0.12 12.7 5.3 3.2 2 1 1 3 3 3 0 DnaJ central domain Cwf_Cwc_15 PF04889.12 ELR24784.1 - 1.6e-71 241.0 31.2 1.8e-71 240.8 31.2 1.0 1 0 0 1 1 1 1 Cwf15/Cwc15 cell cycle control protein MFAP1 PF06991.11 ELR24784.1 - 0.00044 20.2 30.7 0.00058 19.8 30.7 1.2 1 0 0 1 1 1 1 Microfibril-associated/Pre-mRNA processing PA26 PF04636.13 ELR24784.1 - 1.1 8.1 8.4 1.2 7.9 8.4 1.2 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Nop14 PF04147.12 ELR24784.1 - 1.2 7.2 30.3 1.5 6.9 30.3 1.0 1 0 0 1 1 1 0 Nop14-like family AAA_11 PF13086.6 ELR24784.1 - 5.5 6.7 10.9 8.6 6.1 10.9 1.3 1 0 0 1 1 1 0 AAA domain zf-C3HC4_2 PF13923.6 ELR24785.1 - 1.4e-11 44.0 10.8 2.5e-11 43.2 10.8 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 ELR24785.1 - 9.1e-10 38.4 4.3 9.1e-10 38.4 4.3 1.8 1 1 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 ELR24785.1 - 3.8e-09 36.3 9.7 6.7e-09 35.5 9.7 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 ELR24785.1 - 8.7e-09 35.6 7.9 1.6e-08 34.7 7.9 1.5 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.6 ELR24785.1 - 9.2e-08 31.9 7.9 2.4e-07 30.6 8.0 1.7 1 1 0 1 1 1 1 zinc-RING finger domain zf-C3HC4 PF00097.25 ELR24785.1 - 1.1e-07 31.5 9.8 2.1e-07 30.7 9.8 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 ELR24785.1 - 3e-07 30.5 8.2 3e-07 30.5 8.2 2.0 2 1 0 2 2 2 1 zinc finger of C3HC4-type, RING Prok-RING_4 PF14447.6 ELR24785.1 - 1.2e-05 25.0 8.6 2.7e-05 23.9 8.6 1.6 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_10 PF16685.5 ELR24785.1 - 1.4e-05 25.1 4.9 2.5e-05 24.3 4.9 1.4 1 0 0 1 1 1 1 zinc RING finger of MSL2 YEATS PF03366.16 ELR24785.1 - 6.9e-05 22.7 0.1 0.00012 21.9 0.1 1.4 1 0 0 1 1 1 1 YEATS family zf-rbx1 PF12678.7 ELR24785.1 - 0.0014 18.9 9.1 0.0025 18.1 7.4 2.2 2 1 0 2 2 2 1 RING-H2 zinc finger domain U-box PF04564.15 ELR24785.1 - 0.0045 17.1 0.0 0.0087 16.2 0.0 1.4 1 0 0 1 1 1 1 U-box domain zf-Nse PF11789.8 ELR24785.1 - 0.007 16.2 4.4 0.015 15.1 4.4 1.6 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_6 PF14835.6 ELR24785.1 - 0.0084 16.0 4.2 0.0089 15.9 3.0 1.7 2 0 0 2 2 2 1 zf-RING of BARD1-type protein zf-RING_4 PF14570.6 ELR24785.1 - 0.019 14.7 9.9 0.4 10.5 11.0 2.2 1 1 1 2 2 2 0 RING/Ubox like zinc-binding domain zf-ANAPC11 PF12861.7 ELR24785.1 - 0.45 10.6 5.0 1.1 9.4 5.0 1.7 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger RMI1_N PF08585.12 ELR24786.1 - 1e-40 139.9 0.0 1e-40 139.9 0.0 2.2 3 0 0 3 3 3 1 RecQ mediated genome instability protein RMI1_C PF16099.5 ELR24786.1 - 4e-17 62.4 0.0 6.5e-17 61.7 0.0 1.3 1 0 0 1 1 1 1 Recq-mediated genome instability protein 1, C-terminal OB-fold CDC24_OB3 PF17244.2 ELR24786.1 - 0.81 9.3 4.2 0.87 9.3 0.0 2.3 2 0 0 2 2 2 0 Cell division control protein 24, OB domain 3 Usp PF00582.26 ELR24787.1 - 1.2e-28 100.3 3.8 4.2e-28 98.6 0.0 2.9 2 1 0 2 2 2 1 Universal stress protein family PAT1 PF09770.9 ELR24787.1 - 1.1 7.5 13.2 1.6 6.9 13.2 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF3987 PF13148.6 ELR24787.1 - 2.8 6.9 9.5 4.6 6.2 9.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3987) Pex14_N PF04695.13 ELR24787.1 - 4.7 7.8 27.0 0.2 12.3 12.4 2.9 3 0 0 3 3 3 0 Peroxisomal membrane anchor protein (Pex14p) conserved region AstE_AspA PF04952.14 ELR24788.1 - 1.2e-10 41.0 0.1 3.4e-10 39.5 0.0 1.7 2 0 0 2 2 2 1 Succinylglutamate desuccinylase / Aspartoacylase family Proteasome PF00227.26 ELR24789.1 - 8.8e-63 211.2 0.0 1.4e-62 210.6 0.0 1.3 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 ELR24789.1 - 1.9e-14 53.0 0.2 6.5e-14 51.3 0.1 2.0 2 0 0 2 2 2 1 Proteasome subunit A N-terminal signature Cas_CT1975 PF09344.10 ELR24789.1 - 0.022 14.3 1.9 0.031 13.8 1.9 1.2 1 0 0 1 1 1 0 CT1975-like protein RuvA_C PF07499.13 ELR24789.1 - 0.79 10.2 0.0 0.79 10.2 0.0 2.7 3 0 0 3 3 3 0 RuvA, C-terminal domain GIDA PF01134.22 ELR24790.1 - 1.8e-152 508.0 0.0 2.3e-152 507.6 0.0 1.1 1 0 0 1 1 1 1 Glucose inhibited division protein A GIDA_assoc PF13932.6 ELR24790.1 - 5.3e-70 235.9 0.1 7.3e-70 235.4 0.1 1.2 1 0 0 1 1 1 1 GidA associated domain FAD_oxidored PF12831.7 ELR24790.1 - 1.7e-05 24.4 0.2 1.7e-05 24.4 0.2 1.7 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 ELR24790.1 - 0.0021 17.4 0.2 0.0034 16.6 0.2 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 ELR24790.1 - 0.0084 15.2 4.2 0.0092 15.1 2.5 1.8 2 0 0 2 2 2 1 FAD binding domain HI0933_like PF03486.14 ELR24790.1 - 0.028 13.1 1.1 0.19 10.4 0.7 2.1 2 0 0 2 2 2 0 HI0933-like protein AlaDh_PNT_C PF01262.21 ELR24790.1 - 0.044 13.1 0.8 0.097 12.0 0.8 1.5 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Pyr_redox PF00070.27 ELR24790.1 - 0.2 12.3 0.5 0.44 11.1 0.5 1.6 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase MFS_1 PF07690.16 ELR24791.1 - 1.8e-17 63.3 42.1 1.8e-17 63.3 42.1 2.1 1 1 0 2 2 2 2 Major Facilitator Superfamily MFS_4 PF06779.14 ELR24791.1 - 0.0031 16.9 33.1 0.0041 16.5 33.1 1.1 1 0 0 1 1 1 1 Uncharacterised MFS-type transporter YbfB Syntaxin PF00804.25 ELR24792.1 - 6.7e-38 130.4 14.3 6.7e-38 130.4 14.3 1.6 2 0 0 2 2 2 1 Syntaxin Syntaxin_2 PF14523.6 ELR24792.1 - 1.2e-07 32.0 3.9 1.2e-07 32.0 3.9 2.4 2 1 0 2 2 2 1 Syntaxin-like protein SNARE PF05739.19 ELR24792.1 - 1e-06 28.6 6.7 1e-06 28.6 6.7 2.1 2 0 0 2 2 2 1 SNARE domain ydhR PF08803.11 ELR24792.1 - 0.044 13.7 0.1 0.2 11.6 0.1 2.2 1 0 0 1 1 1 0 Putative mono-oxygenase ydhR Rootletin PF15035.6 ELR24792.1 - 0.69 9.9 14.4 3.7 7.5 0.5 2.5 1 1 2 3 3 3 0 Ciliary rootlet component, centrosome cohesion DUF4988 PF16378.5 ELR24792.1 - 0.83 9.3 7.1 4.2 7.0 0.4 2.3 2 0 0 2 2 2 0 Domain of unknown function DUF2207 PF09972.9 ELR24792.1 - 0.98 8.1 5.5 0.32 9.7 0.3 2.1 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) DUF2203 PF09969.9 ELR24792.1 - 1.5 9.5 9.9 1.6 9.5 2.7 2.7 1 1 2 3 3 3 0 Uncharacterized conserved protein (DUF2203) Synaptobrevin PF00957.21 ELR24792.1 - 1.9 8.3 14.2 0.54 10.1 1.8 3.4 3 1 0 3 3 3 0 Synaptobrevin FTO_CTD PF12934.7 ELR24792.1 - 3.4 7.4 7.1 1.3 8.8 1.5 2.6 2 1 1 3 3 3 0 FTO C-terminal domain COMP PF11598.8 ELR24792.1 - 4.6 7.8 0.0 4.6 7.8 0.0 3.8 4 1 0 4 4 3 0 Cartilage oligomeric matrix protein HIT PF01230.23 ELR24792.1 - 4.6 8.0 5.8 28 5.5 0.7 3.5 2 1 0 3 3 3 0 HIT domain PAH PF02671.21 ELR24792.1 - 5.1 7.3 5.6 27 5.0 5.6 2.3 1 1 0 1 1 1 0 Paired amphipathic helix repeat Podoplanin PF05808.11 ELR24792.1 - 5.6 7.1 10.8 8.6 6.4 4.5 2.3 2 0 0 2 2 2 0 Podoplanin YabA PF06156.13 ELR24792.1 - 6.2 7.5 11.9 0.33 11.6 4.0 2.6 1 1 2 3 3 3 0 Initiation control protein YabA SKA1 PF07160.12 ELR24792.1 - 7.7 6.3 16.0 2.9 7.7 2.7 2.7 2 1 0 2 2 2 0 Spindle and kinetochore-associated protein 1 FAM76 PF16046.5 ELR24792.1 - 8.2 5.7 11.5 3.4 6.9 4.6 2.3 2 0 0 2 2 2 0 FAM76 protein Nucleotid_trans PF03407.16 ELR24793.1 - 3.4e-31 108.9 0.2 4.5e-31 108.5 0.2 1.2 1 0 0 1 1 1 1 Nucleotide-diphospho-sugar transferase Nucleotid_trans PF03407.16 ELR24794.1 - 5.6e-22 78.8 0.3 1.1e-11 45.2 0.0 2.1 1 1 1 2 2 2 2 Nucleotide-diphospho-sugar transferase FAP PF07174.11 ELR24794.1 - 0.12 11.8 24.1 0.21 11.0 24.1 1.4 1 0 0 1 1 1 0 Fibronectin-attachment protein (FAP) 2_5_RNA_ligase2 PF13563.6 ELR24795.1 - 4.1e-22 78.7 0.1 6e-22 78.2 0.1 1.2 1 0 0 1 1 1 1 2'-5' RNA ligase superfamily RRM_1 PF00076.22 ELR24795.1 - 2.2e-05 24.2 0.0 4.9e-05 23.1 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) O-FucT PF10250.9 ELR24796.1 - 2.9e-06 27.2 0.0 4.9e-06 26.5 0.0 1.3 1 1 0 1 1 1 1 GDP-fucose protein O-fucosyltransferase Perilipin PF03036.16 ELR24797.1 - 3.4e-08 32.9 0.6 0.00022 20.4 0.0 2.2 1 1 1 2 2 2 2 Perilipin family Opi1 PF08618.10 ELR24797.1 - 0.0042 16.4 0.1 0.0065 15.8 0.1 1.3 1 0 0 1 1 1 1 Transcription factor Opi1 VIT PF08487.10 ELR24799.1 - 6.6e-35 119.7 0.2 6.6e-35 119.7 0.2 2.3 2 0 0 2 2 2 1 Vault protein inter-alpha-trypsin domain VIT_2 PF13757.6 ELR24799.1 - 1.7e-14 53.5 0.2 3.1e-14 52.6 0.2 1.4 1 0 0 1 1 1 1 Vault protein inter-alpha-trypsin domain ESAG1 PF03238.13 ELR24799.1 - 0.18 11.2 0.0 0.31 10.5 0.0 1.3 1 0 0 1 1 1 0 ESAG protein Tim54 PF11711.8 ELR24799.1 - 0.21 10.4 2.1 0.34 9.6 2.1 1.2 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 RNA_pol_Rpc4 PF05132.14 ELR24799.1 - 1.2 9.6 5.8 2.7 8.4 5.8 1.5 1 0 0 1 1 1 0 RNA polymerase III RPC4 Ras PF00071.22 ELR24800.1 - 5e-44 149.8 0.7 5.8e-44 149.6 0.7 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR24800.1 - 1.2e-11 44.9 0.0 1.8e-11 44.3 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR24800.1 - 1.2e-09 37.9 0.0 1.4e-09 37.6 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 ELR24800.1 - 4.3e-07 29.7 0.6 1e-06 28.5 0.5 1.6 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 ELR24800.1 - 0.00094 19.1 0.3 0.0032 17.4 0.1 1.8 1 1 1 2 2 2 1 RsgA GTPase FeoB_N PF02421.18 ELR24800.1 - 0.0013 18.3 0.2 0.013 15.1 0.2 2.0 1 1 0 1 1 1 1 Ferrous iron transport protein B MMR_HSR1 PF01926.23 ELR24800.1 - 0.0019 18.2 0.2 0.0024 17.9 0.2 1.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase DUF971 PF06155.12 ELR24800.1 - 0.085 13.5 0.0 0.22 12.2 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF971) AAA_14 PF13173.6 ELR24800.1 - 0.086 12.9 0.1 0.21 11.6 0.0 1.7 2 0 0 2 2 2 0 AAA domain Aldedh PF00171.22 ELR24801.1 - 0.11 11.0 0.6 0.13 10.8 0.6 1.0 1 0 0 1 1 1 0 Aldehyde dehydrogenase family Aminotran_1_2 PF00155.21 ELR24802.1 - 8.3e-33 114.0 0.0 1e-32 113.7 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.21 ELR24802.1 - 0.0096 15.2 0.0 0.015 14.6 0.0 1.4 1 0 0 1 1 1 1 Beta-eliminating lyase Cys_Met_Meta_PP PF01053.20 ELR24802.1 - 0.13 10.8 0.0 0.21 10.1 0.0 1.2 1 0 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme FdtA PF05523.11 ELR24802.1 - 0.13 12.0 0.0 0.21 11.3 0.0 1.3 1 0 0 1 1 1 0 WxcM-like, C-terminal SPX PF03105.19 ELR24803.1 - 0.00087 19.3 5.6 0.00087 19.3 5.6 1.1 1 0 0 1 1 1 1 SPX domain Pex14_N PF04695.13 ELR24803.1 - 0.31 11.7 11.1 0.68 10.6 11.1 1.6 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Trypan_PARP PF05887.11 ELR24803.1 - 0.38 10.7 16.6 0.6 10.1 16.6 1.3 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) Apt1 PF10351.9 ELR24803.1 - 0.83 8.4 2.3 0.92 8.3 2.3 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain SOG2 PF10428.9 ELR24803.1 - 8 5.5 12.9 11 5.1 12.9 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein BUD22 PF09073.10 ELR24803.1 - 9.4 5.5 10.5 14 4.9 10.5 1.3 1 0 0 1 1 1 0 BUD22 DUF4551 PF15087.6 ELR24803.1 - 9.9 4.9 6.4 12 4.5 6.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) TraB PF01963.17 ELR24804.1 - 0.00013 22.0 0.0 0.44 10.4 0.0 2.2 2 0 0 2 2 2 2 TraB family Metallophos PF00149.28 ELR24806.1 - 3.7e-05 24.3 0.0 0.0025 18.3 0.0 2.2 1 1 1 2 2 2 2 Calcineurin-like phosphoesterase SIR2 PF02146.17 ELR24807.1 - 1.7e-57 194.2 0.0 2.4e-57 193.7 0.0 1.2 1 0 0 1 1 1 1 Sir2 family zf-C3HC4_3 PF13920.6 ELR24807.1 - 0.51 10.2 6.6 0.96 9.4 6.6 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) WD40 PF00400.32 ELR24808.1 - 1.3e-25 89.1 15.2 0.00013 22.7 0.3 6.4 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ELR24808.1 - 0.046 14.0 0.6 2.6 8.4 0.1 3.4 1 1 2 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain Myosin_head PF00063.21 ELR24809.1 - 1.1e-220 734.5 0.0 5.6e-117 391.7 0.0 2.9 2 1 0 2 2 2 2 Myosin head (motor domain) DIL PF01843.19 ELR24809.1 - 2.9e-18 66.1 0.1 1.5e-17 63.7 0.0 2.4 2 0 0 2 2 2 1 DIL domain IQ PF00612.27 ELR24809.1 - 0.00014 21.4 25.3 0.12 12.3 3.2 5.6 5 0 0 5 5 5 3 IQ calmodulin-binding motif AAA_22 PF13401.6 ELR24809.1 - 3.5 7.9 10.1 0.48 10.7 0.1 3.7 2 0 0 2 2 2 0 AAA domain HTH_42 PF06224.12 ELR24810.1 - 5.7e-29 101.7 13.4 9.5e-29 101.0 4.4 2.8 2 1 1 3 3 3 2 Winged helix DNA-binding domain BUD22 PF09073.10 ELR24810.1 - 0.0028 17.1 28.2 0.0028 17.1 28.2 1.9 2 0 0 2 2 2 1 BUD22 Myc_N PF01056.18 ELR24810.1 - 0.31 10.9 24.9 6.9 6.5 21.0 2.7 2 1 0 2 2 2 0 Myc amino-terminal region Amidohydro_1 PF01979.20 ELR24811.1 - 1.8e-62 211.7 0.0 2.2e-62 211.4 0.0 1.1 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 ELR24811.1 - 1.9e-08 34.2 0.1 3.4e-06 26.8 0.0 2.2 2 0 0 2 2 2 2 Amidohydrolase family Amidohydro_1 PF01979.20 ELR24812.1 - 2.4e-67 227.7 0.0 2.8e-67 227.5 0.0 1.0 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 ELR24812.1 - 1.4e-07 31.3 1.5 2.9e-05 23.7 0.0 2.6 2 1 0 3 3 3 2 Amidohydrolase family A_deaminase PF00962.22 ELR24812.1 - 0.00015 21.2 0.0 0.00024 20.6 0.0 1.3 1 0 0 1 1 1 1 Adenosine/AMP deaminase NARG2_C PF10505.9 ELR24813.1 - 1.6e-23 83.3 0.0 2.8e-23 82.6 0.0 1.3 1 0 0 1 1 1 1 NMDA receptor-regulated gene protein 2 C-terminus zf-CCCH PF00642.24 ELR24813.1 - 0.0022 17.9 3.6 0.0037 17.1 3.6 1.4 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 ELR24813.1 - 0.028 14.5 4.1 0.049 13.7 4.1 1.4 1 0 0 1 1 1 0 Zinc finger domain Cys_rich_CPCC PF14206.6 ELR24814.1 - 1.5e-25 88.8 0.2 1.8e-25 88.6 0.2 1.0 1 0 0 1 1 1 1 Cysteine-rich CPCC Kelch_4 PF13418.6 ELR24815.1 - 6.7e-40 134.9 14.6 1.3e-09 37.9 0.0 7.2 6 1 0 6 6 6 6 Galactose oxidase, central domain Kelch_3 PF13415.6 ELR24815.1 - 5.4e-38 128.6 16.0 7.4e-08 32.5 0.0 7.5 7 1 0 7 7 7 5 Galactose oxidase, central domain Kelch_5 PF13854.6 ELR24815.1 - 2.4e-35 119.9 6.2 9.7e-07 28.6 0.0 6.3 6 0 0 6 6 6 6 Kelch motif Kelch_6 PF13964.6 ELR24815.1 - 1.4e-32 110.9 11.8 1.6e-06 28.1 0.0 6.8 5 1 1 6 6 6 6 Kelch motif Kelch_1 PF01344.25 ELR24815.1 - 5.6e-27 93.1 5.8 3.9e-07 29.5 0.0 6.8 6 0 0 6 6 6 5 Kelch motif Kelch_2 PF07646.15 ELR24815.1 - 1.8e-20 72.1 3.0 0.0029 17.5 0.0 6.8 6 1 0 6 6 6 5 Kelch motif Asp PF00026.23 ELR24815.1 - 0.065 12.6 0.0 3 7.2 0.0 2.4 2 1 0 2 2 2 0 Eukaryotic aspartyl protease VanY PF02557.17 ELR24816.1 - 4e-10 39.6 0.0 6.4e-10 38.9 0.0 1.3 1 0 0 1 1 1 1 D-alanyl-D-alanine carboxypeptidase Peptidase_M15_4 PF13539.6 ELR24816.1 - 0.027 15.0 4.5 0.65 10.5 4.5 2.5 2 1 0 2 2 2 0 D-alanyl-D-alanine carboxypeptidase cEGF PF12662.7 ELR24817.1 - 1.7 8.7 19.0 1.3 9.0 0.2 5.5 4 1 1 5 5 5 0 Complement Clr-like EGF-like p450 PF00067.22 ELR24819.1 - 2.4e-35 122.2 6.8 5.6e-24 84.7 4.0 3.3 2 1 0 2 2 2 2 Cytochrome P450 SKG6 PF08693.10 ELR24820.1 - 0.00014 21.2 10.1 0.00014 21.2 10.1 3.1 3 0 0 3 3 3 1 Transmembrane alpha-helix domain FlaE PF07559.14 ELR24820.1 - 0.036 14.6 1.8 0.06 13.9 0.3 2.0 2 0 0 2 2 2 0 Flagellar basal body protein FlaE DUF4448 PF14610.6 ELR24820.1 - 0.12 12.2 0.4 0.23 11.2 0.4 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4448) DUF4307 PF14155.6 ELR24820.1 - 5.7 6.8 8.9 1.2 9.0 0.9 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4307) Helicase_C PF00271.31 ELR24822.1 - 2.2e-07 31.2 0.0 3.7e-07 30.5 0.0 1.3 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ANAPC4_WD40 PF12894.7 ELR24823.1 - 0.0015 18.8 0.1 6.5 7.1 0.0 3.7 3 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain PQQ PF01011.21 ELR24823.1 - 0.0044 16.9 2.6 2.6 8.1 0.0 4.3 4 0 0 4 4 4 2 PQQ enzyme repeat WD40 PF00400.32 ELR24823.1 - 0.0072 17.2 0.0 0.38 11.7 0.0 3.0 2 0 0 2 2 2 1 WD domain, G-beta repeat TrkH PF02386.16 ELR24824.1 - 6.2e-79 265.8 16.8 4.4e-76 256.3 9.4 2.2 2 0 0 2 2 2 2 Cation transport protein RR_TM4-6 PF06459.12 ELR24824.1 - 0.0028 17.5 1.3 0.0028 17.5 1.3 2.1 3 0 0 3 3 3 1 Ryanodine Receptor TM 4-6 Sec62 PF03839.16 ELR24824.1 - 0.015 14.9 5.5 0.036 13.6 5.5 1.7 1 0 0 1 1 1 0 Translocation protein Sec62 SLC12 PF03522.15 ELR24824.1 - 0.37 9.7 4.9 0.72 8.8 4.9 1.4 1 0 0 1 1 1 0 Solute carrier family 12 Rib_recp_KP_reg PF05104.12 ELR24824.1 - 0.52 11.3 18.5 1.3 10.0 18.5 1.6 1 0 0 1 1 1 0 Ribosome receptor lysine/proline rich region Rtf2 PF04641.12 ELR24824.1 - 0.53 9.6 17.7 0.96 8.8 17.7 1.3 1 0 0 1 1 1 0 Rtf2 RING-finger Paramyxo_ncap PF00973.19 ELR24824.1 - 3 6.7 8.2 5.3 5.8 8.2 1.3 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein EIIBC-GUT_N PF03612.14 ELR24824.1 - 4.6 6.9 7.9 8.6 6.1 7.9 1.3 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus TrkH PF02386.16 ELR24825.1 - 3.6e-82 276.4 9.2 5e-82 275.9 9.2 1.2 1 0 0 1 1 1 1 Cation transport protein DUF2417 PF10329.9 ELR24825.1 - 0.68 9.3 4.5 2.9 7.2 2.3 2.9 1 1 1 2 2 2 0 Region of unknown function (DUF2417) CAML PF14963.6 ELR24825.1 - 2.4 8.2 5.7 3.3 7.8 0.0 2.2 2 0 0 2 2 2 0 Calcium signal-modulating cyclophilin ligand RhoGEF PF00621.20 ELR24826.1 - 1.2e-20 74.5 0.8 1.6e-20 74.1 0.8 1.1 1 0 0 1 1 1 1 RhoGEF domain Ras PF00071.22 ELR24827.1 - 3e-45 153.7 0.0 3.4e-45 153.6 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR24827.1 - 4.4e-29 101.1 0.0 6.4e-29 100.6 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR24827.1 - 4.8e-12 45.7 0.0 6.2e-12 45.3 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 ELR24827.1 - 5.2e-08 32.5 0.0 6.1e-08 32.3 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 ELR24827.1 - 0.00031 20.4 0.1 0.0064 16.0 0.1 2.3 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain PduV-EutP PF10662.9 ELR24827.1 - 0.00033 20.4 0.0 0.1 12.4 0.1 2.4 3 0 0 3 3 3 1 Ethanolamine utilisation - propanediol utilisation MMR_HSR1 PF01926.23 ELR24827.1 - 0.00039 20.5 0.0 0.00053 20.0 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_7 PF12775.7 ELR24827.1 - 0.00078 19.0 0.0 0.0011 18.5 0.0 1.2 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_16 PF13191.6 ELR24827.1 - 0.012 16.1 0.0 0.022 15.1 0.0 1.4 1 1 0 1 1 1 0 AAA ATPase domain SRPRB PF09439.10 ELR24827.1 - 0.022 14.2 0.0 0.033 13.6 0.0 1.4 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit ATPase_2 PF01637.18 ELR24827.1 - 0.037 13.9 0.0 0.057 13.3 0.0 1.3 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea G-alpha PF00503.20 ELR24827.1 - 0.054 12.7 0.1 1.1 8.4 0.0 2.1 2 0 0 2 2 2 0 G-protein alpha subunit TniB PF05621.11 ELR24827.1 - 0.056 12.9 0.0 0.089 12.2 0.0 1.3 1 0 0 1 1 1 0 Bacterial TniB protein TsaE PF02367.17 ELR24827.1 - 0.063 13.3 0.0 0.12 12.4 0.0 1.4 1 1 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE DLIC PF05783.11 ELR24827.1 - 0.067 12.0 0.1 2.2 7.0 0.0 2.3 1 1 0 2 2 2 0 Dynein light intermediate chain (DLIC) AAA_22 PF13401.6 ELR24827.1 - 0.068 13.4 0.0 0.1 12.9 0.0 1.5 1 1 0 1 1 1 0 AAA domain cobW PF02492.19 ELR24827.1 - 0.074 12.6 0.0 1.1 8.8 0.0 2.1 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain CxC7 PF18866.1 ELR24827.1 - 0.13 12.5 0.0 0.74 10.0 0.0 2.1 1 1 1 2 2 2 0 CxC7 like cysteine cluster associated with KDZ transposases MMR_HSR1_Xtn PF16897.5 ELR24827.1 - 0.13 12.3 0.0 0.23 11.5 0.0 1.4 1 0 0 1 1 1 0 C-terminal region of MMR_HSR1 domain ATP_bind_1 PF03029.17 ELR24827.1 - 0.19 11.5 0.1 4.6 6.9 0.0 2.1 1 1 1 2 2 2 0 Conserved hypothetical ATP binding protein Ribosomal_L19e PF01280.20 ELR24828.1 - 6e-64 214.5 11.8 6e-64 214.5 11.8 2.3 1 1 2 3 3 3 1 Ribosomal protein L19e Endostatin PF06482.11 ELR24828.1 - 5.8 6.3 9.8 67 2.8 9.5 2.3 1 1 1 2 2 2 0 Collagenase NC10 and Endostatin GlcNAc PF11397.8 ELR24829.1 - 1.1e-71 242.1 0.0 2.7e-71 240.9 0.0 1.5 1 1 0 1 1 1 1 Glycosyltransferase (GlcNAc) Rad17 PF03215.15 ELR24830.1 - 4.8e-20 72.3 0.0 6.2e-18 65.4 0.0 2.3 2 0 0 2 2 2 2 Rad17 P-loop domain AAA_assoc_2 PF16193.5 ELR24830.1 - 0.025 14.9 0.0 0.057 13.8 0.0 1.6 1 0 0 1 1 1 0 AAA C-terminal domain AAA_16 PF13191.6 ELR24830.1 - 0.25 11.7 2.6 0.3 11.4 0.0 2.5 2 1 0 2 2 2 0 AAA ATPase domain Astro_capsid_p PF12226.8 ELR24830.1 - 0.56 9.3 10.8 1 8.4 4.9 2.4 2 0 0 2 2 2 0 Turkey astrovirus capsid protein RXT2_N PF08595.11 ELR24830.1 - 5.9 6.9 15.6 8 6.5 7.3 2.8 2 0 0 2 2 2 0 RXT2-like, N-terminal EF_assoc_2 PF08356.12 ELR24831.1 - 8.2e-28 96.2 0.0 5.5e-26 90.4 0.0 3.0 4 0 0 4 4 3 1 EF hand associated Ras PF00071.22 ELR24831.1 - 1.3e-17 63.8 0.0 1.1e-10 41.3 0.0 3.3 2 2 1 3 3 3 2 Ras family EF_assoc_1 PF08355.12 ELR24831.1 - 4.6e-13 48.6 1.5 9e-13 47.6 0.4 2.1 2 0 0 2 2 2 1 EF hand associated Roc PF08477.13 ELR24831.1 - 3.8e-10 40.0 0.1 0.0012 19.1 0.0 3.6 2 2 1 3 3 3 2 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR24831.1 - 1.3e-05 24.7 0.1 0.085 12.3 0.0 2.8 2 1 1 3 3 3 2 ADP-ribosylation factor family AAA_25 PF13481.6 ELR24831.1 - 0.00016 21.3 0.0 0.00039 20.0 0.0 1.7 1 0 0 1 1 1 1 AAA domain EF-hand_1 PF00036.32 ELR24831.1 - 0.00044 19.6 0.1 0.0011 18.4 0.1 1.7 1 0 0 1 1 1 1 EF hand GTP_EFTU PF00009.27 ELR24831.1 - 0.00051 19.6 0.2 0.084 12.4 0.0 2.2 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain EF-hand_6 PF13405.6 ELR24831.1 - 0.0014 18.4 0.2 0.0041 16.9 0.2 1.8 1 0 0 1 1 1 1 EF-hand domain EF-hand_7 PF13499.6 ELR24831.1 - 0.0018 18.7 0.0 0.006 17.0 0.0 1.9 1 0 0 1 1 1 1 EF-hand domain pair MMR_HSR1 PF01926.23 ELR24831.1 - 0.0025 17.9 0.0 0.67 10.0 0.0 2.7 2 1 1 3 3 3 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 ELR24831.1 - 0.004 17.1 0.0 0.058 13.3 0.0 2.3 1 1 1 2 2 2 1 RsgA GTPase SPARC_Ca_bdg PF10591.9 ELR24831.1 - 0.0095 16.2 0.6 0.12 12.6 0.6 2.6 1 1 0 1 1 1 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_5 PF13202.6 ELR24831.1 - 0.013 15.0 0.6 0.042 13.4 0.6 1.9 1 0 0 1 1 1 0 EF hand Gtr1_RagA PF04670.12 ELR24831.1 - 0.018 14.4 0.1 0.53 9.6 0.0 2.2 1 1 1 2 2 2 0 Gtr1/RagA G protein conserved region AAA_22 PF13401.6 ELR24831.1 - 0.026 14.8 0.0 0.095 13.0 0.0 1.9 1 1 0 1 1 1 0 AAA domain ABC_tran PF00005.27 ELR24831.1 - 0.027 15.0 0.0 0.046 14.2 0.0 1.4 1 0 0 1 1 1 0 ABC transporter EF-hand_10 PF14788.6 ELR24831.1 - 0.071 13.0 0.1 0.17 11.8 0.1 1.5 1 0 0 1 1 1 0 EF hand AAA_16 PF13191.6 ELR24831.1 - 0.091 13.1 1.4 0.47 10.8 0.0 2.8 3 1 0 3 3 2 0 AAA ATPase domain Septin PF00735.18 ELR24831.1 - 0.099 11.9 0.0 0.17 11.2 0.0 1.3 1 0 0 1 1 1 0 Septin AAA_24 PF13479.6 ELR24831.1 - 0.12 12.0 0.0 0.3 10.8 0.0 1.6 2 0 0 2 2 2 0 AAA domain Dynamin_N PF00350.23 ELR24831.1 - 0.16 12.0 0.0 0.3 11.1 0.0 1.5 1 0 0 1 1 1 0 Dynamin family G-alpha PF00503.20 ELR24831.1 - 0.19 10.8 0.0 11 5.1 0.0 2.2 1 1 1 2 2 2 0 G-protein alpha subunit V_ATPase_I PF01496.19 ELR24832.1 - 0 1032.8 10.6 0 1025.3 10.6 2.0 1 1 0 1 1 1 1 V-type ATPase 116kDa subunit family FapA PF03961.13 ELR24832.1 - 0.0025 16.5 0.7 0.0041 15.8 0.7 1.2 1 0 0 1 1 1 1 Flagellar Assembly Protein A DASH_Dam1 PF08653.10 ELR24832.1 - 0.0047 16.7 2.6 0.22 11.3 0.9 4.1 4 0 0 4 4 4 1 DASH complex subunit Dam1 MAD PF05557.13 ELR24832.1 - 0.0052 15.2 7.0 0.0087 14.5 7.0 1.2 1 0 0 1 1 1 1 Mitotic checkpoint protein HMMR_N PF15905.5 ELR24832.1 - 0.22 10.9 8.8 0.38 10.2 8.8 1.3 1 0 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal bZIP_1 PF00170.21 ELR24832.1 - 0.47 10.6 3.2 1.1 9.4 3.2 1.6 1 0 0 1 1 1 0 bZIP transcription factor APG6_N PF17675.1 ELR24832.1 - 0.5 10.9 8.5 1.4 9.4 8.5 1.7 1 0 0 1 1 1 0 Apg6 coiled-coil region Occludin_ELL PF07303.13 ELR24832.1 - 0.51 11.1 4.1 7.4 7.4 0.8 2.9 3 0 0 3 3 3 0 Occludin homology domain HSBP1 PF06825.12 ELR24832.1 - 0.64 9.9 4.7 0.79 9.6 0.2 3.0 3 0 0 3 3 3 0 Heat shock factor binding protein 1 Rho_Binding PF08912.11 ELR24832.1 - 1.3 9.9 9.4 14 6.6 0.3 2.8 2 0 0 2 2 2 0 Rho Binding TolA_bind_tri PF16331.5 ELR24832.1 - 2.2 8.4 6.4 27 4.9 0.0 2.9 2 2 0 2 2 2 0 TolA binding protein trimerisation Filament PF00038.21 ELR24832.1 - 2.6 7.6 11.8 0.17 11.5 6.1 1.8 2 0 0 2 2 2 0 Intermediate filament protein ABC_tran_CTD PF16326.5 ELR24832.1 - 2.8 8.3 7.8 17 5.7 7.8 2.4 2 1 0 2 2 2 0 ABC transporter C-terminal domain RasGEF PF00617.19 ELR24833.1 - 1.2e-53 181.9 0.4 2.4e-53 180.9 0.0 1.7 2 0 0 2 2 2 1 RasGEF domain RasGEF_N PF00618.20 ELR24833.1 - 6.3e-25 87.5 0.1 1.9e-24 85.9 0.1 1.9 1 0 0 1 1 1 1 RasGEF N-terminal motif DUF4140 PF13600.6 ELR24833.1 - 2.5 8.6 4.6 43 4.6 0.0 3.3 3 0 0 3 3 3 0 N-terminal domain of unknown function (DUF4140) Com_YlbF PF06133.11 ELR24833.1 - 3.1 8.5 6.4 10 6.8 3.3 2.3 2 0 0 2 2 2 0 Control of competence regulator ComK, YlbF/YmcA MDD_C PF18376.1 ELR24834.1 - 4.4e-74 248.3 0.0 6.5e-74 247.7 0.0 1.2 1 0 0 1 1 1 1 Mevalonate 5-diphosphate decarboxylase C-terminal domain GHMP_kinases_N PF00288.26 ELR24834.1 - 5.5e-05 23.3 1.3 0.00015 22.0 1.3 1.7 1 0 0 1 1 1 1 GHMP kinases N terminal domain 3HCDH_N PF02737.18 ELR24835.1 - 3.4e-23 82.4 0.0 5.4e-23 81.8 0.0 1.3 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain zf-C3HC4_3 PF13920.6 ELR24835.1 - 2.2e-15 56.2 2.9 2.2e-15 56.2 2.9 2.3 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 ELR24835.1 - 1.9e-07 30.8 5.5 1.9e-07 30.8 5.5 2.3 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-RING_2 PF13639.6 ELR24835.1 - 1.1e-06 28.9 5.2 4.6e-06 26.9 5.2 2.2 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 ELR24835.1 - 1.1e-06 28.3 5.5 1.1e-06 28.3 5.5 2.3 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 ELR24835.1 - 6.9e-06 25.8 4.8 6.9e-06 25.8 4.8 2.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ELR24835.1 - 7.7e-05 22.6 5.0 0.00016 21.5 5.0 1.6 1 0 0 1 1 1 1 zinc-RING finger domain ApbA PF02558.16 ELR24835.1 - 0.0001 22.0 0.1 0.00019 21.1 0.1 1.4 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA zf-CCHH PF10283.9 ELR24835.1 - 0.012 15.6 0.1 0.012 15.6 0.1 5.4 4 2 1 5 5 5 0 PBZ domain NAD_binding_2 PF03446.15 ELR24835.1 - 0.02 15.0 0.0 0.03 14.5 0.0 1.3 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase 2-Hacid_dh_C PF02826.19 ELR24835.1 - 0.022 14.1 0.0 0.037 13.4 0.0 1.2 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Pyr_redox PF00070.27 ELR24835.1 - 0.026 15.1 0.0 0.057 14.0 0.0 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 ELR24835.1 - 0.034 13.4 0.0 0.056 12.7 0.0 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Sacchrp_dh_NADP PF03435.18 ELR24835.1 - 0.04 14.2 0.0 0.1 12.8 0.0 1.7 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain NAD_Gly3P_dh_N PF01210.23 ELR24835.1 - 0.062 13.3 0.0 0.1 12.5 0.0 1.3 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus zf-P11 PF03854.14 ELR24835.1 - 0.14 11.9 0.8 0.26 11.0 0.8 1.5 1 0 0 1 1 1 0 P-11 zinc finger DUF1188 PF06690.11 ELR24835.1 - 0.15 11.6 0.0 0.25 10.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1188) Shikimate_DH PF01488.20 ELR24835.1 - 0.16 12.0 0.0 0.38 10.8 0.0 1.5 2 0 0 2 2 1 0 Shikimate / quinate 5-dehydrogenase oligo_HPY PF08352.12 ELR24835.1 - 0.27 11.8 4.0 4.4 7.9 0.0 3.1 2 1 0 2 2 2 0 Oligopeptide/dipeptide transporter, C-terminal region zf-RING_UBOX PF13445.6 ELR24835.1 - 2.2 8.4 8.4 0.19 11.8 1.1 2.7 2 0 0 2 2 2 0 RING-type zinc-finger RecR PF02132.15 ELR24835.1 - 4.7 6.9 7.2 0.24 11.0 1.0 2.1 3 0 0 3 3 1 0 RecR protein Myosin_head PF00063.21 ELR24836.1 - 3.8e-221 736.0 0.1 4.7e-163 544.0 0.0 2.2 1 1 1 2 2 2 2 Myosin head (motor domain) MyTH4 PF00784.17 ELR24836.1 - 5.9e-44 149.0 0.0 1.1e-20 74.1 0.0 2.9 2 0 0 2 2 2 2 MyTH4 domain FERM_M PF00373.18 ELR24836.1 - 5.6e-21 75.1 0.3 4.4e-13 49.7 0.0 3.2 3 0 0 3 3 3 2 FERM central domain SH3_2 PF07653.17 ELR24836.1 - 6.3e-14 51.4 0.0 1.3e-13 50.3 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 ELR24836.1 - 1.5e-11 43.7 0.3 5e-11 42.0 0.1 2.1 2 0 0 2 2 2 1 SH3 domain SH3_9 PF14604.6 ELR24836.1 - 3.7e-10 39.5 0.5 1.7e-09 37.4 0.0 2.4 3 0 0 3 3 3 1 Variant SH3 domain FERM_N PF09379.10 ELR24836.1 - 1.8e-07 31.0 0.6 0.00044 20.1 0.0 2.7 2 0 0 2 2 2 2 FERM N-terminal domain IQ PF00612.27 ELR24836.1 - 3.1e-05 23.4 13.2 0.098 12.5 0.3 3.8 3 0 0 3 3 3 2 IQ calmodulin-binding motif AAA_22 PF13401.6 ELR24836.1 - 0.0048 17.2 0.0 0.039 14.2 0.0 2.7 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 ELR24836.1 - 0.038 14.4 0.0 0.038 14.4 0.0 3.2 2 1 0 2 2 1 0 AAA ATPase domain RsgA_GTPase PF03193.16 ELR24836.1 - 0.16 11.8 0.0 0.43 10.5 0.0 1.6 1 0 0 1 1 1 0 RsgA GTPase Methyltransf_16 PF10294.9 ELR24837.1 - 5.1e-23 81.7 0.0 6.5e-23 81.3 0.0 1.1 1 0 0 1 1 1 1 Lysine methyltransferase Cons_hypoth95 PF03602.15 ELR24837.1 - 7.2e-07 29.0 0.0 9.6e-07 28.6 0.0 1.2 1 0 0 1 1 1 1 Conserved hypothetical protein 95 MTS PF05175.14 ELR24837.1 - 1.1e-05 25.0 0.0 1.6e-05 24.5 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain PrmA PF06325.13 ELR24837.1 - 0.0009 18.7 0.0 0.0011 18.5 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_25 PF13649.6 ELR24837.1 - 0.0013 19.4 0.0 0.0019 18.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Met_10 PF02475.16 ELR24837.1 - 0.0044 16.8 0.0 0.0062 16.3 0.0 1.2 1 0 0 1 1 1 1 Met-10+ like-protein PCMT PF01135.19 ELR24837.1 - 0.02 14.6 0.0 0.041 13.6 0.0 1.5 2 0 0 2 2 2 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_23 PF13489.6 ELR24837.1 - 0.061 13.1 0.0 0.077 12.8 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_31 PF13847.6 ELR24837.1 - 0.069 12.9 0.0 0.077 12.8 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain TehB PF03848.14 ELR24837.1 - 0.09 12.2 0.0 0.11 11.9 0.0 1.2 1 0 0 1 1 1 0 Tellurite resistance protein TehB Ras PF00071.22 ELR24839.1 - 3.9e-57 192.4 0.1 4.7e-57 192.1 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR24839.1 - 7.3e-34 116.6 0.1 1.1e-33 115.9 0.1 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR24839.1 - 9.3e-18 64.3 0.1 1.1e-17 64.0 0.1 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 ELR24839.1 - 8.6e-07 28.7 0.2 4.9e-06 26.2 0.0 2.0 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 ELR24839.1 - 1.5e-05 25.0 0.3 0.04 13.8 0.1 2.3 1 1 1 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 ELR24839.1 - 2.6e-05 24.2 0.0 3.9e-05 23.7 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 ELR24839.1 - 0.0001 21.8 0.0 0.00012 21.6 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region AAA_7 PF12775.7 ELR24839.1 - 0.0031 17.1 0.1 0.0063 16.1 0.0 1.5 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_16 PF13191.6 ELR24839.1 - 0.017 15.5 0.0 0.035 14.5 0.0 1.8 1 1 0 1 1 1 0 AAA ATPase domain SRPRB PF09439.10 ELR24839.1 - 0.018 14.5 0.0 0.023 14.2 0.0 1.3 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit MCM PF00493.23 ELR24839.1 - 0.018 14.1 0.0 0.028 13.5 0.0 1.3 1 0 0 1 1 1 0 MCM P-loop domain ATP_bind_1 PF03029.17 ELR24839.1 - 0.02 14.7 0.0 0.41 10.4 0.0 2.0 1 1 1 2 2 2 0 Conserved hypothetical ATP binding protein AAA_29 PF13555.6 ELR24839.1 - 0.021 14.5 0.0 0.047 13.4 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain TniB PF05621.11 ELR24839.1 - 0.03 13.8 0.0 0.042 13.2 0.0 1.2 1 0 0 1 1 1 0 Bacterial TniB protein AAA_22 PF13401.6 ELR24839.1 - 0.032 14.5 0.0 0.08 13.2 0.0 1.7 1 1 0 1 1 1 0 AAA domain AAA_5 PF07728.14 ELR24839.1 - 0.044 13.8 0.0 0.1 12.6 0.0 1.6 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) NACHT PF05729.12 ELR24839.1 - 0.053 13.4 0.0 0.085 12.8 0.0 1.3 1 0 0 1 1 1 0 NACHT domain FeoB_N PF02421.18 ELR24839.1 - 0.063 12.8 0.0 0.98 8.9 0.0 2.3 1 1 0 1 1 1 0 Ferrous iron transport protein B DAP3 PF10236.9 ELR24839.1 - 0.11 11.6 0.1 0.15 11.2 0.1 1.2 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 Helicase_C_2 PF13307.6 ELR24841.1 - 5.8e-54 182.8 0.3 1.6e-53 181.4 0.0 2.0 2 0 0 2 2 2 1 Helicase C-terminal domain DEAD_2 PF06733.15 ELR24841.1 - 1.6e-38 132.1 0.1 4.1e-38 130.7 0.1 1.7 1 0 0 1 1 1 1 DEAD_2 DEAD PF00270.29 ELR24841.1 - 0.051 13.4 0.0 6.1 6.6 0.0 2.5 2 0 0 2 2 2 0 DEAD/DEAH box helicase DUF4216 PF13952.6 ELR24841.1 - 0.076 13.4 0.0 0.18 12.2 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4216) DUF3446 PF11928.8 ELR24841.1 - 2.1 8.7 16.9 13 6.1 11.0 2.7 2 0 0 2 2 2 0 Early growth response N-terminal domain Abhydrolase_3 PF07859.13 ELR24842.1 - 5.9e-34 117.8 0.1 3.1e-23 82.7 0.0 3.0 1 1 1 2 2 2 2 alpha/beta hydrolase fold Say1_Mug180 PF10340.9 ELR24842.1 - 1.1e-11 44.2 0.0 1.1e-10 40.9 0.0 2.1 2 0 0 2 2 2 1 Steryl acetyl hydrolase p450 PF00067.22 ELR24843.1 - 1.6e-73 248.0 0.0 8.5e-73 245.7 0.0 1.8 1 1 0 1 1 1 1 Cytochrome P450 PFK PF00365.20 ELR24845.1 - 7.4e-186 616.1 1.7 5.9e-102 340.8 2.3 2.6 2 1 0 2 2 2 2 Phosphofructokinase MR_MLE_C PF13378.6 ELR24846.1 - 1e-47 162.5 0.0 1.6e-47 161.9 0.0 1.2 1 0 0 1 1 1 1 Enolase C-terminal domain-like MR_MLE_N PF02746.16 ELR24846.1 - 1.3e-10 41.5 0.0 2.1e-10 40.8 0.0 1.3 1 0 0 1 1 1 1 Mandelate racemase / muconate lactonizing enzyme, N-terminal domain His_Phos_1 PF00300.22 ELR24849.1 - 3.8e-22 78.9 0.0 1.6e-21 76.9 0.0 1.8 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) Ras PF00071.22 ELR24850.1 - 7.7e-43 145.9 0.2 9.3e-43 145.6 0.2 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR24850.1 - 7.3e-28 97.2 0.0 1.4e-27 96.3 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR24850.1 - 9.2e-12 44.8 0.1 1.1e-11 44.4 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 ELR24850.1 - 2.9e-06 26.8 0.0 3.5e-06 26.6 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 ELR24850.1 - 0.0018 17.8 0.1 0.013 15.0 0.1 2.1 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 ELR24850.1 - 0.0024 17.9 0.0 0.0038 17.3 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_16 PF13191.6 ELR24850.1 - 0.0044 17.4 0.0 0.15 12.4 0.0 2.2 1 1 1 2 2 2 1 AAA ATPase domain PduV-EutP PF10662.9 ELR24850.1 - 0.0095 15.7 0.1 3.3 7.5 0.0 2.2 2 0 0 2 2 2 2 Ethanolamine utilisation - propanediol utilisation AAA_7 PF12775.7 ELR24850.1 - 0.018 14.5 0.0 0.032 13.7 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region G-alpha PF00503.20 ELR24850.1 - 0.023 13.9 0.1 0.76 8.9 0.1 2.0 2 0 0 2 2 2 0 G-protein alpha subunit SRPRB PF09439.10 ELR24850.1 - 0.032 13.7 0.0 0.1 12.1 0.0 1.8 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit NKWYS PF10364.9 ELR24850.1 - 0.032 14.3 0.1 0.063 13.4 0.1 1.4 1 0 0 1 1 1 0 Putative capsular polysaccharide synthesis protein MMR_HSR1_Xtn PF16897.5 ELR24850.1 - 0.045 13.8 0.2 0.09 12.8 0.1 1.4 1 1 0 1 1 1 0 C-terminal region of MMR_HSR1 domain TsaE PF02367.17 ELR24850.1 - 0.077 13.0 0.1 0.17 11.9 0.1 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE TniB PF05621.11 ELR24850.1 - 0.09 12.2 0.0 0.24 10.8 0.0 1.6 2 0 0 2 2 2 0 Bacterial TniB protein DLIC PF05783.11 ELR24850.1 - 0.094 11.5 0.7 0.95 8.2 0.1 2.2 1 1 1 2 2 2 0 Dynein light intermediate chain (DLIC) Cytochrom_C PF00034.21 ELR24851.1 - 9.9e-11 42.6 0.8 2.3e-10 41.5 0.8 1.6 1 1 0 1 1 1 1 Cytochrome c Cytochrome_CBB3 PF13442.6 ELR24851.1 - 3.1e-08 33.8 1.5 8e-08 32.5 1.5 1.6 1 1 0 1 1 1 1 Cytochrome C oxidase, cbb3-type, subunit III Cytochrom_C550 PF14495.6 ELR24851.1 - 0.00089 19.0 1.1 0.0034 17.1 0.1 2.2 2 1 0 2 2 2 1 Cytochrome c-550 domain Cytochrome-c551 PF10643.9 ELR24851.1 - 0.022 14.3 0.0 0.024 14.2 0.0 1.2 1 0 0 1 1 1 0 Photosystem P840 reaction-centre cytochrome c-551 HSP70 PF00012.20 ELR24852.1 - 2.8e-80 270.2 43.1 2e-77 260.8 0.8 3.8 3 1 1 4 4 4 3 Hsp70 protein MreB_Mbl PF06723.13 ELR24852.1 - 0.0069 15.2 0.3 0.064 12.1 0.0 2.1 2 0 0 2 2 2 1 MreB/Mbl protein AbiEi_3_N PF17194.4 ELR24852.1 - 0.016 15.2 0.0 0.039 14.0 0.0 1.6 1 0 0 1 1 1 0 Transcriptional regulator, AbiEi antitoxin N-terminal domain motB PF17613.2 ELR24852.1 - 0.094 12.6 0.0 0.2 11.5 0.0 1.5 1 0 0 1 1 1 0 Modifier of transcription Zip PF02535.22 ELR24852.1 - 9.6 5.3 7.0 29 3.7 7.0 1.8 1 0 0 1 1 1 0 ZIP Zinc transporter ADH_zinc_N_2 PF13602.6 ELR24854.1 - 3.7e-22 79.8 0.0 6.3e-22 79.1 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.26 ELR24854.1 - 2.2e-19 69.7 0.1 5.6e-19 68.4 0.1 1.7 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 ELR24854.1 - 2.4e-09 37.0 0.0 6e-09 35.8 0.0 1.7 1 1 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain SR-25 PF10500.9 ELR24854.1 - 0.0028 17.3 8.8 0.0028 17.3 8.8 1.8 2 0 0 2 2 2 1 Nuclear RNA-splicing-associated protein IMUP PF15761.5 ELR24854.1 - 0.027 15.2 8.2 0.027 15.2 8.2 2.1 2 0 0 2 2 2 0 Immortalisation up-regulated protein YjeF_N PF03853.15 ELR24854.1 - 0.027 14.4 0.1 0.069 13.0 0.1 1.7 1 0 0 1 1 1 0 YjeF-related protein N-terminus ACP_syn_III_C PF08541.10 ELR24854.1 - 0.027 14.6 0.1 0.081 13.1 0.1 1.9 1 0 0 1 1 1 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal zf-RING_9 PF13901.6 ELR24855.1 - 1.6e-54 185.1 9.8 2.3e-54 184.5 9.8 1.2 1 0 0 1 1 1 1 Putative zinc-RING and/or ribbon RUN PF02759.19 ELR24855.1 - 5.8e-15 55.4 0.1 1.5e-14 54.1 0.1 1.7 1 0 0 1 1 1 1 RUN domain HisKA PF00512.25 ELR24855.1 - 0.14 12.2 0.1 0.14 12.2 0.1 2.9 4 0 0 4 4 4 0 His Kinase A (phospho-acceptor) domain Pilosulin PF17499.2 ELR24855.1 - 0.17 12.1 0.0 0.43 10.8 0.0 1.6 1 0 0 1 1 1 0 Ant venom peptides Zn-ribbon_8 PF09723.10 ELR24855.1 - 0.93 9.7 7.0 2 8.6 3.4 2.6 2 0 0 2 2 2 0 Zinc ribbon domain C1_1 PF00130.22 ELR24855.1 - 1.6 8.7 5.4 4.6 7.2 5.3 1.8 1 1 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-CCHC PF00098.23 ELR24856.1 - 5.3e-12 45.2 19.7 6.7e-07 29.1 2.6 2.6 3 0 0 3 3 3 2 Zinc knuckle BAH PF01426.18 ELR24856.1 - 0.0001 22.1 0.0 0.00025 20.9 0.0 1.7 1 0 0 1 1 1 1 BAH domain Plus-3 PF03126.18 ELR24856.1 - 0.00052 20.5 0.0 0.0012 19.3 0.0 1.6 1 0 0 1 1 1 1 Plus-3 domain zf-CCHC_5 PF14787.6 ELR24856.1 - 0.00068 19.3 7.7 0.073 12.8 1.0 2.5 2 0 0 2 2 2 2 GAG-polyprotein viral zinc-finger zf-CCHC_3 PF13917.6 ELR24856.1 - 0.0014 18.5 9.0 0.25 11.4 0.6 3.0 3 0 0 3 3 3 2 Zinc knuckle zf-CCHC_2 PF13696.6 ELR24856.1 - 0.0034 17.2 8.5 0.12 12.2 0.8 2.5 2 0 0 2 2 2 2 Zinc knuckle DUF1465 PF07323.12 ELR24856.1 - 0.019 14.8 0.8 0.019 14.8 0.8 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1465) GREB1 PF15782.5 ELR24856.1 - 4 4.4 7.1 7.6 3.5 7.1 1.3 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Methyltransf_24 PF13578.6 ELR24857.1 - 1.2e-08 35.9 0.0 2.1e-08 35.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Surp PF01805.20 ELR24858.1 - 7e-19 67.6 0.3 1.5e-18 66.5 0.3 1.6 1 0 0 1 1 1 1 Surp module RRM_1 PF00076.22 ELR24858.1 - 5.3e-18 64.6 0.0 1.2e-17 63.4 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CTD_bind PF04818.13 ELR24858.1 - 4e-08 34.0 0.1 1.2e-07 32.4 0.1 1.9 1 0 0 1 1 1 1 RNA polymerase II-binding domain. CTK3 PF12243.8 ELR24858.1 - 4.9e-06 26.6 0.0 1e-05 25.5 0.0 1.5 1 0 0 1 1 1 1 CTD kinase subunit gamma CTK3 RRM_5 PF13893.6 ELR24858.1 - 0.011 15.3 0.0 0.026 14.1 0.0 1.5 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Het-C PF07217.11 ELR24858.1 - 0.15 10.6 0.1 0.29 9.6 0.0 1.4 2 0 0 2 2 2 0 Heterokaryon incompatibility protein Het-C TFIIA PF03153.13 ELR24858.1 - 0.79 9.6 9.9 0.15 12.1 0.2 2.4 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Adaptin_binding PF10199.9 ELR24858.1 - 1.7 9.3 14.7 0.077 13.6 2.0 3.2 2 1 0 2 2 2 0 Alpha and gamma adaptin binding protein p34 TMEM131_like PF12371.8 ELR24859.1 - 3.6e-31 107.2 7.2 2.4e-26 91.8 1.4 6.9 8 0 0 8 8 8 2 Transmembrane protein 131-like ASH PF15780.5 ELR24859.1 - 2.6e-07 30.8 7.3 0.021 15.0 1.0 5.6 6 0 0 6 6 6 3 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin LRR_4 PF12799.7 ELR24860.1 - 1.2e-23 82.8 22.9 2.4e-06 27.8 3.2 5.4 4 1 2 6 6 6 6 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 ELR24860.1 - 1.8e-23 82.1 18.3 1.6e-06 27.8 10.2 4.8 3 2 1 5 5 5 4 Leucine rich repeat DSPc PF00782.20 ELR24860.1 - 1.9e-13 50.4 0.0 5.8e-07 29.4 0.0 2.7 1 1 1 2 2 2 2 Dual specificity phosphatase, catalytic domain LRR_9 PF14580.6 ELR24860.1 - 2.8e-05 23.7 6.4 0.055 13.0 1.5 3.3 3 0 0 3 3 3 2 Leucine-rich repeat RP-C_C PF11800.8 ELR24860.1 - 2.8e-05 24.3 7.1 0.00097 19.3 0.3 2.5 2 0 0 2 2 2 2 Replication protein C C-terminal region LRR_6 PF13516.6 ELR24860.1 - 6.6e-05 22.7 14.8 14 6.0 0.9 6.8 6 0 0 6 6 6 0 Leucine Rich repeat LRR_1 PF00560.33 ELR24860.1 - 0.0039 17.5 22.2 2.9 8.8 0.1 6.6 6 1 0 6 6 5 1 Leucine Rich Repeat DUF3530 PF12048.8 ELR24860.1 - 0.0057 16.1 0.1 0.0057 16.1 0.1 2.4 2 0 0 2 2 2 1 Protein of unknown function (DUF3530) EOS1 PF12326.8 ELR24860.1 - 0.8 9.6 4.2 7.2 6.5 0.1 2.6 2 0 0 2 2 2 0 N-glycosylation protein BORG_CEP PF14957.6 ELR24860.1 - 1.2 10.3 11.7 3.8 8.7 2.0 2.7 2 0 0 2 2 2 0 Cdc42 effector GAGA_bind PF06217.12 ELR24860.1 - 1.4 9.1 15.3 0.96 9.7 1.9 2.2 2 0 0 2 2 2 0 GAGA binding protein-like family Baculo_PP31 PF05311.11 ELR24860.1 - 1.7 8.1 18.4 3.2 7.2 6.1 2.2 2 0 0 2 2 2 0 Baculovirus 33KDa late protein (PP31) Smg8_Smg9 PF10220.9 ELR24860.1 - 1.7 6.8 16.1 2 6.6 3.2 2.1 2 0 0 2 2 2 0 Smg8_Smg9 RPOL_N PF14700.6 ELR24860.1 - 2.2 7.6 13.9 0.6 9.4 1.0 2.4 2 0 0 2 2 2 0 DNA-directed RNA polymerase N-terminal DUF2828 PF11443.8 ELR24860.1 - 2.8 5.9 16.9 0.99 7.4 3.6 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF2828) DUF4228 PF14009.6 ELR24860.1 - 3 8.2 12.7 11 6.4 4.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4228) DUF2052 PF09747.9 ELR24860.1 - 3.4 7.7 34.2 1.2 9.3 14.3 2.5 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) SAPS PF04499.15 ELR24860.1 - 4.3 6.0 17.8 0.19 10.5 1.5 2.1 2 0 0 2 2 2 0 SIT4 phosphatase-associated protein DUF913 PF06025.12 ELR24860.1 - 5.2 5.9 12.3 1.4 7.8 0.8 2.3 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) Neur_chan_memb PF02932.16 ELR24860.1 - 6.2 6.8 9.3 7 6.6 0.2 2.5 3 0 0 3 3 3 0 Neurotransmitter-gated ion-channel transmembrane region PPP4R2 PF09184.11 ELR24860.1 - 6.7 6.2 24.9 0.044 13.4 2.6 2.5 2 0 0 2 2 2 0 PPP4R2 RNA_pol_Rpc4 PF05132.14 ELR24860.1 - 9.2 6.7 26.3 0.084 13.3 1.6 3.2 3 1 1 4 4 3 0 RNA polymerase III RPC4 N_BRCA1_IG PF16158.5 ELR24861.1 - 5.9e-31 107.2 0.4 2.3e-30 105.4 0.0 2.2 2 0 0 2 2 2 1 Ig-like domain from next to BRCA1 gene PB1 PF00564.24 ELR24861.1 - 1.1e-15 57.3 1.2 1.6e-14 53.6 0.4 2.4 2 0 0 2 2 2 1 PB1 domain ZZ PF00569.17 ELR24861.1 - 1.8e-11 43.7 6.5 3e-11 43.0 6.5 1.3 1 0 0 1 1 1 1 Zinc finger, ZZ type C1_2 PF03107.16 ELR24861.1 - 0.0069 16.7 6.2 0.013 15.8 6.2 1.4 1 0 0 1 1 1 1 C1 domain Gin PF10764.9 ELR24861.1 - 4.9 7.2 7.2 0.8 9.7 0.9 2.3 1 1 1 2 2 2 0 Inhibitor of sigma-G Gin Erf4 PF10256.9 ELR24862.1 - 1.7e-06 28.1 0.1 3.5e-05 23.9 0.1 2.1 1 1 0 1 1 1 1 Golgin subfamily A member 7/ERF4 family PKD_channel PF08016.12 ELR24862.1 - 0.00017 20.4 1.0 0.00021 20.1 1.0 1.1 1 0 0 1 1 1 1 Polycystin cation channel DUF2070 PF09843.9 ELR24862.1 - 0.17 10.1 3.2 0.22 9.8 3.2 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) PspB PF06667.12 ELR24862.1 - 0.81 9.8 8.1 0.33 11.0 3.7 2.4 2 1 1 3 3 3 0 Phage shock protein B Adenylsucc_synt PF00709.21 ELR24863.1 - 6.2e-169 562.4 0.0 1.2e-168 561.5 0.0 1.4 1 1 0 1 1 1 1 Adenylosuccinate synthetase HTH_Tnp_IS1 PF12759.7 ELR24863.1 - 0.11 12.1 0.2 0.27 10.9 0.2 1.6 1 0 0 1 1 1 0 InsA C-terminal domain Cofilin_ADF PF00241.20 ELR24864.1 - 8.1e-07 28.9 0.0 1e-06 28.6 0.0 1.2 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein GTP_EFTU PF00009.27 ELR24865.1 - 8.2e-16 58.1 0.0 1.3e-15 57.5 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain F-box-like PF12937.7 ELR24865.1 - 2.8e-05 23.9 2.6 5.7e-05 22.9 2.6 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ELR24865.1 - 0.00071 19.4 1.3 0.0014 18.4 1.3 1.4 1 0 0 1 1 1 1 F-box domain MMR_HSR1 PF01926.23 ELR24865.1 - 0.067 13.3 0.0 0.11 12.5 0.0 1.4 1 0 0 1 1 1 0 50S ribosome-binding GTPase Peptidase_M28 PF04389.17 ELR24866.1 - 2.6e-38 131.7 0.0 5.1e-38 130.8 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M28 PA PF02225.22 ELR24866.1 - 9.1e-07 28.8 0.0 1.7e-06 27.9 0.0 1.4 1 0 0 1 1 1 1 PA domain Peptidase_M20 PF01546.28 ELR24866.1 - 0.0088 15.8 0.0 0.021 14.5 0.0 1.6 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 Erf4 PF10256.9 ELR24867.1 - 0.21 11.7 0.0 1.2 9.2 0.0 2.0 1 1 0 1 1 1 0 Golgin subfamily A member 7/ERF4 family SnoaL_2 PF12680.7 ELR24868.1 - 6.5e-09 36.4 0.0 9.4e-09 35.8 0.0 1.3 1 0 0 1 1 1 1 SnoaL-like domain SnoaL_3 PF13474.6 ELR24868.1 - 0.00061 20.0 0.0 0.00064 20.0 0.0 1.1 1 0 0 1 1 1 1 SnoaL-like domain RdRP_3 PF00998.23 ELR24868.1 - 0.021 13.5 0.0 0.022 13.5 0.0 1.0 1 0 0 1 1 1 0 Viral RNA dependent RNA polymerase DUF4440 PF14534.6 ELR24868.1 - 0.051 14.0 0.0 0.058 13.8 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4440) EF-hand_5 PF13202.6 ELR24868.1 - 0.059 12.9 0.2 0.1 12.2 0.2 1.4 1 0 0 1 1 1 0 EF hand DUF2283 PF10049.9 ELR24868.1 - 0.059 13.6 0.3 0.15 12.3 0.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2283) EF-hand_6 PF13405.6 ELR24868.1 - 0.077 13.0 0.1 0.2 11.7 0.1 1.7 1 0 0 1 1 1 0 EF-hand domain OAD_gamma PF04277.13 ELR24869.1 - 0.0005 20.6 0.2 2.1 9.0 0.0 3.0 3 0 0 3 3 3 2 Oxaloacetate decarboxylase, gamma chain Yip1 PF04893.17 ELR24869.1 - 0.00082 19.1 7.9 0.078 12.7 1.2 2.8 3 0 0 3 3 3 2 Yip1 domain DUF4834 PF16118.5 ELR24869.1 - 0.0074 17.2 9.7 0.53 11.3 1.0 4.2 4 1 0 4 4 4 2 Domain of unknown function (DUF4834) FAM176 PF14851.6 ELR24869.1 - 0.037 13.7 0.0 0.35 10.5 0.0 2.1 2 0 0 2 2 2 0 FAM176 family NAM-associated PF14303.6 ELR24869.1 - 0.048 14.4 3.0 0.052 14.3 0.0 2.0 2 0 0 2 2 2 0 No apical meristem-associated C-terminal domain HemY_N PF07219.13 ELR24869.1 - 0.2 11.8 0.0 0.2 11.8 0.0 3.7 4 0 0 4 4 4 0 HemY protein N-terminus Voltage_CLC PF00654.20 ELR24869.1 - 0.41 9.8 5.4 0.18 11.1 0.3 2.4 3 0 0 3 3 3 0 Voltage gated chloride channel TMEM208_SND2 PF05620.11 ELR24869.1 - 0.89 9.3 7.2 0.87 9.3 1.3 3.1 3 0 0 3 3 3 0 SRP-independent targeting protein 2/TMEM208 Abhydrolase_9_N PF15420.6 ELR24869.1 - 3.6 7.5 5.8 0.71 9.8 0.4 2.4 3 1 0 3 3 3 0 Alpha/beta-hydrolase family N-terminus EPSP_synthase PF00275.20 ELR24870.1 - 9.2e-128 426.5 0.0 1.3e-127 426.0 0.0 1.1 1 0 0 1 1 1 1 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) DHQ_synthase PF01761.20 ELR24870.1 - 1.7e-97 325.7 0.0 3.7e-97 324.6 0.0 1.6 2 0 0 2 2 2 1 3-dehydroquinate synthase DHquinase_I PF01487.15 ELR24870.1 - 2.6e-44 152.2 0.0 2.3e-42 145.8 0.0 3.0 3 0 0 3 3 3 1 Type I 3-dehydroquinase SKI PF01202.22 ELR24870.1 - 6.3e-32 110.9 0.1 2.5e-29 102.4 0.0 2.6 2 0 0 2 2 2 2 Shikimate kinase Fe-ADH_2 PF13685.6 ELR24870.1 - 2.2e-09 37.4 0.0 7.8e-09 35.6 0.0 1.9 1 1 0 1 1 1 1 Iron-containing alcohol dehydrogenase Fe-ADH PF00465.19 ELR24870.1 - 7.6e-05 21.7 1.1 0.00015 20.7 0.0 2.0 3 0 0 3 3 3 1 Iron-containing alcohol dehydrogenase AAA_33 PF13671.6 ELR24870.1 - 0.0073 16.5 0.0 0.021 15.0 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 ELR24870.1 - 0.075 13.6 0.0 0.16 12.5 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 ELR24870.1 - 0.076 13.4 0.0 0.19 12.1 0.0 1.7 1 0 0 1 1 1 0 AAA ATPase domain AAA PF00004.29 ELR24870.1 - 0.11 12.9 0.0 0.41 11.1 0.0 2.0 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Cofilin_ADF PF00241.20 ELR24871.1 - 0.0018 18.0 0.8 0.018 14.8 0.0 2.5 2 0 0 2 2 2 1 Cofilin/tropomyosin-type actin-binding protein Mif2_N PF15624.6 ELR24871.1 - 0.0078 16.9 13.5 0.0078 16.9 13.5 5.1 2 2 0 2 2 2 1 Kinetochore CENP-C fungal homologue, Mif2, N-terminal Exo_endo_phos PF03372.23 ELR24872.1 - 1.8e-16 60.4 0.0 2.4e-16 60.0 0.0 1.2 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family PQ-loop PF04193.14 ELR24873.1 - 3.6e-19 68.3 20.8 2.1e-10 40.2 2.7 3.2 3 0 0 3 3 3 2 PQ loop repeat Chordopox_G3 PF06129.12 ELR24873.1 - 0.055 14.2 0.5 0.15 12.8 0.5 1.7 1 0 0 1 1 1 0 Chordopoxvirus G3 protein DUF2417 PF10329.9 ELR24873.1 - 4.3 6.7 17.3 0.046 13.2 4.7 2.2 1 1 1 2 2 2 0 Region of unknown function (DUF2417) DRY_EERY PF09750.9 ELR24874.1 - 1.4e-15 57.8 21.4 1.4e-15 57.8 21.4 5.1 3 2 0 4 4 4 1 Alternative splicing regulator SH3_9 PF14604.6 ELR24874.1 - 5.2e-10 39.0 0.1 9.6e-10 38.2 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 ELR24874.1 - 1.3e-08 34.4 0.1 2.5e-08 33.5 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain Surp PF01805.20 ELR24874.1 - 2.1e-07 30.8 0.0 6.5e-07 29.2 0.0 1.8 1 0 0 1 1 1 1 Surp module SH3_1 PF00018.28 ELR24874.1 - 6.7e-07 28.8 0.0 1.3e-06 27.9 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SR-25 PF10500.9 ELR24874.1 - 6.3 6.3 98.3 0.013 15.1 49.9 3.9 3 1 1 4 4 4 0 Nuclear RNA-splicing-associated protein AP_endonuc_2 PF01261.24 ELR24876.1 - 1.8e-10 40.6 0.0 2.7e-10 40.1 0.0 1.3 1 0 0 1 1 1 1 Xylose isomerase-like TIM barrel LigD_N PF13298.6 ELR24876.1 - 0.027 14.8 0.0 0.094 13.0 0.0 1.9 2 0 0 2 2 2 0 DNA polymerase Ligase (LigD) PH PF00169.29 ELR24877.1 - 3.7e-13 49.9 0.0 8.9e-13 48.7 0.0 1.7 1 0 0 1 1 1 1 PH domain PH_11 PF15413.6 ELR24877.1 - 6.5e-06 26.5 0.2 0.00019 21.8 0.0 4.0 2 0 0 2 2 2 1 Pleckstrin homology domain PH_12 PF16457.5 ELR24877.1 - 0.00014 22.4 0.9 0.004 17.7 0.0 4.2 2 0 0 2 2 2 1 Pleckstrin homology domain PH_3 PF14593.6 ELR24877.1 - 0.00017 21.6 0.1 0.74 10.0 0.0 2.9 1 1 1 2 2 2 2 PH domain Fez1 PF06818.15 ELR24877.1 - 0.0038 17.7 13.6 0.0038 17.7 13.6 20.7 3 1 15 18 18 18 5 Fez1 PH_8 PF15409.6 ELR24877.1 - 0.016 15.4 0.6 3.4 8.0 0.6 3.6 1 1 0 1 1 1 0 Pleckstrin homology domain UPF0728 PF15092.6 ELR24877.1 - 0.026 14.4 2.5 12 5.8 0.0 5.3 6 0 0 6 6 6 0 Uncharacterised protein family UPF0728 NPR2 PF06218.11 ELR24878.1 - 9.7e-97 324.5 0.1 3.5e-50 171.1 0.8 3.0 1 1 2 3 3 3 3 Nitrogen permease regulator 2 NPR3 PF03666.13 ELR24878.1 - 0.00028 19.8 0.0 0.023 13.5 0.0 2.1 2 0 0 2 2 2 2 Nitrogen Permease regulator of amino acid transport activity 3 HTH_47 PF16221.5 ELR24878.1 - 0.022 14.3 0.0 1.5 8.4 0.0 2.4 2 0 0 2 2 2 0 winged helix-turn-helix BCS1_N PF08740.11 ELR24879.1 - 7.8e-39 133.6 0.0 7.8e-39 133.6 0.0 2.1 2 0 0 2 2 2 1 BCS1 N terminal AAA PF00004.29 ELR24879.1 - 4.5e-18 66.0 0.0 1.1e-17 64.7 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 ELR24879.1 - 0.00078 19.2 0.0 0.0015 18.3 0.0 1.3 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain SR-25 PF10500.9 ELR24879.1 - 0.0042 16.7 20.0 0.0042 16.7 20.0 1.5 2 0 0 2 2 1 1 Nuclear RNA-splicing-associated protein PPV_E1_C PF00519.17 ELR24879.1 - 0.0068 15.3 0.0 0.012 14.5 0.0 1.3 1 0 0 1 1 1 1 Papillomavirus helicase AAA_5 PF07728.14 ELR24879.1 - 0.0086 16.1 0.8 0.12 12.4 0.0 2.7 2 1 0 2 2 1 1 AAA domain (dynein-related subfamily) RNA_helicase PF00910.22 ELR24879.1 - 0.01 16.2 0.0 0.029 14.8 0.0 1.9 1 1 0 1 1 1 0 RNA helicase TIP49 PF06068.13 ELR24879.1 - 0.013 14.7 0.0 0.022 14.0 0.0 1.3 1 0 0 1 1 1 0 TIP49 P-loop domain AAA_33 PF13671.6 ELR24879.1 - 0.02 15.0 0.1 0.071 13.3 0.1 2.1 1 1 0 1 1 1 0 AAA domain BBL5 PF07289.11 ELR24879.1 - 0.022 13.8 3.1 0.034 13.2 3.1 1.2 1 0 0 1 1 1 0 Bardet-Biedl syndrome 5 protein IstB_IS21 PF01695.17 ELR24879.1 - 0.031 14.0 0.0 0.068 12.9 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_24 PF13479.6 ELR24879.1 - 0.039 13.7 0.1 0.18 11.5 0.0 2.1 2 0 0 2 2 2 0 AAA domain XRN_M PF17846.1 ELR24879.1 - 0.048 12.6 7.5 0.073 12.0 7.5 1.3 1 0 0 1 1 1 0 Xrn1 helical domain AAA_25 PF13481.6 ELR24879.1 - 0.076 12.6 0.0 0.16 11.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain PI3K_1B_p101 PF10486.9 ELR24879.1 - 0.096 10.5 7.4 0.14 9.9 7.4 1.2 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit TERB2 PF15101.6 ELR24879.1 - 0.14 12.2 6.8 0.22 11.6 6.8 1.4 1 0 0 1 1 1 0 Telomere-associated protein TERB2 NEMP PF10225.9 ELR24879.1 - 0.24 11.0 2.2 0.53 9.9 2.2 1.5 1 0 0 1 1 1 0 NEMP family AAA_16 PF13191.6 ELR24879.1 - 0.26 11.6 0.0 0.26 11.6 0.0 2.6 2 2 0 2 2 1 0 AAA ATPase domain AAA_18 PF13238.6 ELR24879.1 - 0.4 11.2 0.0 0.4 11.2 0.0 2.6 2 0 0 2 2 1 0 AAA domain Rrn6 PF10214.9 ELR24879.1 - 0.58 8.6 8.4 0.81 8.1 8.4 1.2 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor Menin PF05053.13 ELR24879.1 - 1.6 7.0 9.9 2.2 6.5 9.9 1.1 1 0 0 1 1 1 0 Menin BSP_II PF05432.11 ELR24879.1 - 2.1 8.0 21.7 3.7 7.2 21.7 1.3 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) Roughex PF06020.11 ELR24879.1 - 3.3 6.7 11.9 5.2 6.1 11.9 1.2 1 0 0 1 1 1 0 Drosophila roughex protein DUF913 PF06025.12 ELR24879.1 - 3.4 6.6 9.1 6 5.7 9.1 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) DUF755 PF05501.11 ELR24879.1 - 4.9 7.5 24.4 0.46 10.8 19.9 1.6 2 0 0 2 2 1 0 Domain of unknown function (DUF755) AAA_11 PF13086.6 ELR24879.1 - 5 6.8 17.0 5.8 6.6 0.0 2.4 2 1 0 2 2 1 0 AAA domain GREB1 PF15782.5 ELR24879.1 - 5 4.1 9.2 6.8 3.7 9.2 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Hydin_ADK PF17213.3 ELR24879.1 - 5.3 7.3 11.2 27 5.0 9.3 2.3 2 0 0 2 2 2 0 Hydin Adenylate kinase-like domain Na_trans_assoc PF06512.13 ELR24879.1 - 5.5 7.2 15.0 11 6.3 15.0 1.4 1 0 0 1 1 1 0 Sodium ion transport-associated Neur_chan_memb PF02932.16 ELR24879.1 - 8 6.4 5.4 13 5.7 5.4 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region SLC12 PF03522.15 ELR24879.1 - 8.4 5.3 9.3 12 4.8 9.3 1.2 1 0 0 1 1 1 0 Solute carrier family 12 Hid1 PF12722.7 ELR24879.1 - 9.8 4.2 11.0 13 3.8 11.0 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Adaptin_N PF01602.20 ELR24880.1 - 1.1e-93 314.7 7.0 1.3e-93 314.3 7.0 1.1 1 0 0 1 1 1 1 Adaptin N terminal region AP4E_app_platf PF14807.6 ELR24880.1 - 7.8e-19 67.9 0.1 1.6e-18 66.9 0.1 1.6 1 0 0 1 1 1 1 Adaptin AP4 complex epsilon appendage platform Cnd1 PF12717.7 ELR24880.1 - 8e-10 39.0 3.0 8.2e-09 35.7 0.1 3.1 3 1 0 3 3 3 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 ELR24880.1 - 7.3e-06 26.3 1.9 0.0026 18.1 0.2 4.0 3 2 1 4 4 4 1 HEAT repeats HEAT PF02985.22 ELR24880.1 - 0.0007 19.6 2.8 0.18 12.2 0.0 4.7 6 0 0 6 6 6 1 HEAT repeat ParcG PF10274.9 ELR24880.1 - 0.0016 18.6 5.2 0.6 10.2 0.1 3.4 4 0 0 4 4 4 2 Parkin co-regulated protein HEAT_EZ PF13513.6 ELR24880.1 - 0.002 18.6 1.8 4.9 7.8 0.0 4.3 3 0 0 3 3 3 2 HEAT-like repeat Coatomer_b_Cpla PF14806.6 ELR24880.1 - 0.17 11.9 0.0 0.41 10.6 0.0 1.6 1 0 0 1 1 1 0 Coatomer beta subunit appendage platform RTP1_C1 PF10363.9 ELR24880.1 - 1.6 8.9 5.1 18 5.5 0.0 4.3 4 1 0 4 4 4 0 Required for nuclear transport of RNA pol II C-terminus 1 FPN1 PF06963.12 ELR24881.1 - 8e-98 327.8 23.4 2.1e-58 197.9 14.7 3.0 2 1 0 2 2 2 2 Ferroportin1 (FPN1) MFS_1 PF07690.16 ELR24881.1 - 1.3e-05 24.3 42.4 0.00017 20.7 3.9 3.3 2 1 1 3 3 3 2 Major Facilitator Superfamily Chordopox_A13L PF05961.11 ELR24881.1 - 0.14 12.4 0.9 19 5.5 0.0 2.6 2 0 0 2 2 2 0 Chordopoxvirus A13L protein RhoGEF PF00621.20 ELR24882.1 - 3.6e-46 157.7 1.1 7.2e-46 156.7 1.1 1.5 1 0 0 1 1 1 1 RhoGEF domain APG6_N PF17675.1 ELR24882.1 - 0.0021 18.6 3.0 0.0021 18.6 3.0 2.7 2 0 0 2 2 2 1 Apg6 coiled-coil region IRS PF02174.17 ELR24882.1 - 0.0046 16.8 0.0 0.01 15.7 0.0 1.5 1 0 0 1 1 1 1 PTB domain (IRS-1 type) AAA_23 PF13476.6 ELR24882.1 - 0.058 13.9 5.9 0.86 10.1 0.0 2.6 3 0 0 3 3 3 0 AAA domain PH_16 PF17838.1 ELR24882.1 - 0.074 12.9 0.0 2.1 8.2 0.0 2.3 2 0 0 2 2 2 0 PH domain Folliculin PF11704.8 ELR24882.1 - 0.093 12.6 0.8 2.9 7.7 0.3 2.9 2 0 0 2 2 2 0 Vesicle coat protein involved in Golgi to plasma membrane transport ERM PF00769.19 ELR24882.1 - 0.51 10.1 14.9 0.29 10.9 2.2 2.6 2 0 0 2 2 2 0 Ezrin/radixin/moesin family BST2 PF16716.5 ELR24882.1 - 2.6 8.7 9.6 0.15 12.7 1.7 2.7 2 0 0 2 2 2 0 Bone marrow stromal antigen 2 DUF1168 PF06658.12 ELR24882.1 - 8.3 6.2 27.1 0.53 10.1 9.5 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF1168) CbiA PF01656.23 ELR24883.1 - 0.16 12.0 0.9 0.75 9.9 0.9 2.1 1 0 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain C9orf72-like PF15019.6 ELR24884.1 - 5.9e-40 137.4 0.0 7.6e-40 137.0 0.0 1.1 1 0 0 1 1 1 1 C9orf72-like protein family Cullin PF00888.22 ELR24885.1 - 1.1e-06 27.6 4.5 1.5e-06 27.2 4.5 1.2 1 0 0 1 1 1 1 Cullin family CdvA PF18822.1 ELR24885.1 - 0.00071 19.4 1.0 0.02 14.7 0.4 2.4 2 0 0 2 2 2 1 CdvA-like coiled-coil domain GAS PF13851.6 ELR24885.1 - 0.023 14.0 8.8 0.068 12.5 8.8 1.7 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding Wtap PF17098.5 ELR24885.1 - 0.036 14.0 5.1 0.7 9.8 5.1 2.5 1 1 0 1 1 1 0 WTAP/Mum2p family YabA PF06156.13 ELR24885.1 - 0.058 14.0 0.6 0.058 14.0 0.6 2.3 2 1 0 2 2 2 0 Initiation control protein YabA Omega-toxin PF06357.11 ELR24885.1 - 0.073 12.9 1.8 0.21 11.4 1.8 1.7 1 0 0 1 1 1 0 Omega-atracotoxin RXT2_N PF08595.11 ELR24885.1 - 0.44 10.6 3.8 1.1 9.3 3.8 1.6 1 0 0 1 1 1 0 RXT2-like, N-terminal AAA_23 PF13476.6 ELR24885.1 - 0.44 11.0 3.5 0.69 10.4 3.5 1.3 1 0 0 1 1 1 0 AAA domain Sporozoite_P67 PF05642.11 ELR24885.1 - 0.57 8.2 4.8 0.82 7.7 4.8 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen DUF2721 PF11026.8 ELR24885.1 - 0.65 9.9 3.4 1.6 8.6 3.4 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2721) CENP-B_dimeris PF09026.10 ELR24885.1 - 0.98 9.8 17.4 2 8.8 17.4 1.5 1 0 0 1 1 1 0 Centromere protein B dimerisation domain PilJ PF13675.6 ELR24885.1 - 1.1 9.3 7.6 1.9 8.6 0.8 2.8 2 1 1 3 3 3 0 Type IV pili methyl-accepting chemotaxis transducer N-term Occludin_ELL PF07303.13 ELR24885.1 - 2 9.2 9.9 0.55 11.0 3.0 2.7 2 1 1 3 3 3 0 Occludin homology domain Mod_r PF07200.13 ELR24885.1 - 3.3 7.8 13.0 1.2 9.2 6.0 2.4 2 1 0 2 2 2 0 Modifier of rudimentary (Mod(r)) protein Retrotrans_gag PF03732.17 ELR24885.1 - 4.4 7.6 7.0 6.5 7.1 3.8 2.6 3 0 0 3 3 3 0 Retrotransposon gag protein FapA PF03961.13 ELR24885.1 - 5.8 5.4 5.3 2.8 6.5 2.1 1.8 2 0 0 2 2 2 0 Flagellar Assembly Protein A RICTOR_N PF14664.6 ELR24886.1 - 4.9e-62 210.1 0.0 8.1e-56 189.6 0.0 3.7 3 1 0 3 3 3 2 Rapamycin-insensitive companion of mTOR, N-term RICTOR_M PF14666.6 ELR24886.1 - 2.7e-32 110.6 3.2 2.8e-31 107.4 0.3 3.9 5 0 0 5 5 5 1 Rapamycin-insensitive companion of mTOR, middle domain RICTOR_V PF14668.6 ELR24886.1 - 5.7e-22 77.7 0.3 4.2e-12 46.1 0.0 4.2 4 0 0 4 4 4 2 Rapamycin-insensitive companion of mTOR, domain 5 RasGEF_N_2 PF14663.6 ELR24886.1 - 5.6e-18 65.3 0.0 2.2e-16 60.2 0.0 3.0 2 0 0 2 2 2 1 Rapamycin-insensitive companion of mTOR RasGEF_N domain HEAT_2 PF13646.6 ELR24886.1 - 0.00059 20.2 3.5 18 5.8 0.0 5.3 5 0 0 5 5 5 1 HEAT repeats HEAT_EZ PF13513.6 ELR24886.1 - 0.0049 17.3 0.1 37 5.0 0.0 4.4 3 0 0 3 3 3 0 HEAT-like repeat Arm PF00514.23 ELR24886.1 - 0.038 14.0 3.1 99 3.2 0.1 5.5 5 1 1 6 6 6 0 Armadillo/beta-catenin-like repeat RasGAP PF00616.19 ELR24887.1 - 7.7e-55 185.8 1.5 7.7e-55 185.8 1.5 3.7 4 2 0 4 4 4 1 GTPase-activator protein for Ras-like GTPase RasGAP_C PF03836.15 ELR24887.1 - 7.2e-29 100.7 6.2 7.2e-29 100.7 6.2 3.3 5 0 0 5 5 5 1 RasGAP C-terminus Ntox46 PF15538.6 ELR24887.1 - 0.029 14.3 0.0 0.064 13.2 0.0 1.5 1 0 0 1 1 1 0 Bacterial toxin 46 Antimicrobial20 PF08256.11 ELR24887.1 - 0.65 10.7 2.9 1.7 9.4 2.9 1.8 1 0 0 1 1 1 0 Aurein-like antibiotic peptide Snapin_Pallidin PF14712.6 ELR24887.1 - 8.8 6.8 13.6 0.63 10.5 3.5 3.6 4 0 0 4 4 4 0 Snapin/Pallidin Lipase_3 PF01764.25 ELR24888.1 - 1.3e-22 80.1 0.0 2.4e-22 79.3 0.0 1.4 1 0 0 1 1 1 1 Lipase (class 3) Abhydrolase_6 PF12697.7 ELR24888.1 - 0.86 10.2 6.0 0.59 10.7 3.5 1.9 1 1 1 2 2 2 0 Alpha/beta hydrolase family ADH_zinc_N_2 PF13602.6 ELR24889.1 - 1.1e-16 62.1 0.0 1.9e-16 61.3 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.26 ELR24889.1 - 3.2e-13 49.8 0.0 9.5e-13 48.3 0.0 1.8 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_N PF08240.12 ELR24889.1 - 1.3e-06 28.2 0.0 3.2e-05 23.8 0.0 2.4 1 1 1 2 2 2 1 Alcohol dehydrogenase GroES-like domain LRR_6 PF13516.6 ELR24891.1 - 1.3e-10 40.5 2.0 0.22 11.6 0.0 6.2 6 0 0 6 6 6 4 Leucine Rich repeat LRR_4 PF12799.7 ELR24891.1 - 9.8e-08 32.2 1.8 0.038 14.4 0.1 4.8 2 1 4 7 7 7 4 Leucine Rich repeats (2 copies) F-box-like PF12937.7 ELR24891.1 - 1.4e-06 28.1 0.9 1.4e-06 28.1 0.9 2.0 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 ELR24891.1 - 0.00038 20.3 0.4 0.00096 19.0 0.4 1.7 1 0 0 1 1 1 1 F-box domain LRR_8 PF13855.6 ELR24891.1 - 0.0082 15.9 0.7 0.76 9.6 0.1 3.6 3 1 0 3 3 3 1 Leucine rich repeat FNIP PF05725.12 ELR24891.1 - 0.017 15.3 0.1 1.7 8.8 0.3 3.6 3 1 1 4 4 4 0 FNIP Repeat LRR_1 PF00560.33 ELR24891.1 - 0.04 14.4 2.4 5.7 7.9 0.3 4.8 4 1 1 5 5 5 0 Leucine Rich Repeat QueC PF06508.13 ELR24893.1 - 0.072 12.6 0.1 4.9 6.6 0.0 2.0 1 1 1 2 2 2 0 Queuosine biosynthesis protein QueC Frizzled PF01534.17 ELR24894.1 - 1.7e-23 83.2 13.0 1.7e-23 83.2 13.0 2.1 1 1 1 2 2 2 1 Frizzled/Smoothened family membrane region Fz PF01392.22 ELR24894.1 - 2.4e-08 34.6 0.3 5.2e-08 33.5 0.3 1.5 1 0 0 1 1 1 1 Fz domain Dicty_CAR PF05462.11 ELR24894.1 - 7.8e-08 31.8 9.6 1.4e-07 30.9 9.6 1.5 1 0 0 1 1 1 1 Slime mold cyclic AMP receptor 7tm_2 PF00002.24 ELR24894.1 - 0.00014 21.2 10.6 0.00034 20.0 10.6 1.6 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) DUF751 PF05421.11 ELR24894.1 - 7.4 7.4 11.9 0.72 10.6 0.8 3.5 3 0 0 3 3 3 0 Protein of unknown function (DUF751) Frizzled PF01534.17 ELR24895.1 - 1.3e-22 80.3 22.1 2.1e-22 79.6 22.2 1.3 1 1 0 1 1 1 1 Frizzled/Smoothened family membrane region Fz PF01392.22 ELR24895.1 - 2.8e-08 34.4 1.0 6.9e-08 33.1 1.0 1.6 1 0 0 1 1 1 1 Fz domain Dicty_CAR PF05462.11 ELR24895.1 - 2.5e-06 26.8 14.1 2.5e-06 26.8 14.1 1.8 1 1 1 2 2 2 1 Slime mold cyclic AMP receptor RRM_1 PF00076.22 ELR24896.1 - 4.5e-14 52.0 0.0 1.2e-13 50.7 0.0 1.8 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 ELR24896.1 - 0.0029 17.7 0.0 0.012 15.7 0.0 2.1 1 0 0 1 1 1 1 RNA recognition motif Mucin PF01456.17 ELR24896.1 - 6.5 6.7 11.9 0.34 10.9 3.8 2.2 2 0 0 2 2 2 0 Mucin-like glycoprotein FYVE PF01363.21 ELR24898.1 - 1.9e-06 27.9 3.2 3.7e-06 27.0 3.2 1.4 1 0 0 1 1 1 1 FYVE zinc finger FYVE_2 PF02318.16 ELR24898.1 - 0.023 14.9 1.8 0.023 14.9 1.8 1.9 2 0 0 2 2 2 0 FYVE-type zinc finger DiS_P_DiS PF06750.13 ELR24898.1 - 0.055 13.6 0.7 0.12 12.5 0.7 1.6 1 0 0 1 1 1 0 Bacterial Peptidase A24 N-terminal domain His_Phos_1 PF00300.22 ELR24899.1 - 1.4e-25 90.1 0.0 6.8e-15 55.3 0.0 2.1 2 0 0 2 2 2 2 Histidine phosphatase superfamily (branch 1) Mt_ATP_synt PF15704.5 ELR24900.1 - 0.0061 16.5 2.3 0.01 15.8 2.3 1.3 1 0 0 1 1 1 1 Mitochondrial ATP synthase subunit TetR_C_21 PF17926.1 ELR24900.1 - 0.011 15.8 0.1 0.02 15.0 0.1 1.3 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain AAA_11 PF13086.6 ELR24900.1 - 0.027 14.2 0.2 0.032 14.0 0.2 1.1 1 0 0 1 1 1 0 AAA domain PLATZ PF04640.14 ELR24900.1 - 0.17 12.5 3.5 0.29 11.8 3.5 1.5 1 0 0 1 1 1 0 PLATZ transcription factor Methyltransf_25 PF13649.6 ELR24901.1 - 2.3e-09 37.9 0.0 3.5e-09 37.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ELR24901.1 - 7.1e-08 33.0 0.0 1.2e-07 32.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 ELR24901.1 - 4.6e-07 29.8 0.0 6.1e-07 29.4 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ELR24901.1 - 5.1e-05 23.1 0.0 6.3e-05 22.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ELR24901.1 - 0.035 14.8 0.0 0.055 14.2 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain FMN_red PF03358.15 ELR24902.1 - 4.4e-37 127.2 0.0 3.6e-36 124.3 0.0 1.9 2 0 0 2 2 2 1 NADPH-dependent FMN reductase Flavodoxin_2 PF02525.17 ELR24902.1 - 5.4e-06 26.2 0.0 8.3e-06 25.6 0.0 1.4 1 0 0 1 1 1 1 Flavodoxin-like fold Exo84_C PF16528.5 ELR24903.1 - 1.9e-32 112.7 0.7 7.1e-32 110.9 0.1 2.1 2 0 0 2 2 2 1 Exocyst component 84 C-terminal Vps51 PF08700.11 ELR24903.1 - 1.4e-08 34.7 0.5 6.5e-08 32.6 0.1 2.3 2 0 0 2 2 2 1 Vps51/Vps67 SPATA24 PF15175.6 ELR24903.1 - 0.2 11.6 2.1 0.23 11.3 0.2 1.9 2 0 0 2 2 2 0 Spermatogenesis-associated protein 24 Gelsolin PF00626.22 ELR24904.1 - 1.9e-15 56.5 0.0 1.2e-08 34.7 0.0 3.6 2 0 0 2 2 2 2 Gelsolin repeat VHP PF02209.19 ELR24904.1 - 8.6e-15 54.5 4.1 8.6e-15 54.5 4.1 3.3 2 0 0 2 2 2 1 Villin headpiece domain BRE1 PF08647.11 ELR24904.1 - 0.00043 20.3 17.4 0.00043 20.3 17.4 9.7 5 3 2 9 9 9 1 BRE1 E3 ubiquitin ligase Fez1 PF06818.15 ELR24904.1 - 0.0068 16.9 22.9 0.0068 16.9 22.9 6.1 3 2 3 6 6 6 2 Fez1 CvfB_WH PF17783.1 ELR24904.1 - 0.013 15.3 0.9 2 8.3 0.1 2.7 2 0 0 2 2 2 0 CvfB-like winged helix domain MORN PF02493.20 ELR24905.1 - 1.1e-48 160.3 84.4 2.6e-08 33.3 1.3 10.4 10 0 0 10 10 10 9 MORN repeat F-box-like PF12937.7 ELR24905.1 - 7.5e-10 38.5 0.1 1.3e-09 37.7 0.1 1.4 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ELR24905.1 - 0.0015 18.3 0.1 0.004 17.0 0.1 1.8 1 0 0 1 1 1 1 F-box domain rpo132 PF12415.8 ELR24905.1 - 0.21 10.9 0.5 0.6 9.4 0.2 1.9 2 0 0 2 2 2 0 Poxvirus DNA dependent RNA polymerase Tudor_2 PF18104.1 ELR24905.1 - 0.4 10.4 2.9 4.3 7.1 0.2 3.5 3 0 0 3 3 3 0 Jumonji domain-containing protein 2A Tudor domain Mago_nashi PF02792.14 ELR24906.1 - 3.5e-76 254.1 0.2 3.9e-76 254.0 0.2 1.0 1 0 0 1 1 1 1 Mago nashi protein Got1 PF04178.12 ELR24907.1 - 1.9e-32 112.0 24.6 2.6e-32 111.6 24.6 1.2 1 0 0 1 1 1 1 Got1/Sft2-like family Abhydrolase_3 PF07859.13 ELR24908.1 - 2.2e-15 57.1 3.3 2.3e-14 53.8 3.3 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold COesterase PF00135.28 ELR24908.1 - 8.1e-11 41.5 0.2 1.5e-10 40.6 0.2 1.3 1 1 0 1 1 1 1 Carboxylesterase family Hydrolase_4 PF12146.8 ELR24908.1 - 1e-08 34.8 5.0 0.00015 21.1 2.2 3.0 2 1 0 2 2 2 2 Serine aminopeptidase, S33 Peptidase_S9 PF00326.21 ELR24908.1 - 2.8e-08 33.5 0.5 5e-06 26.1 0.1 2.4 2 1 0 2 2 2 2 Prolyl oligopeptidase family Abhydrolase_6 PF12697.7 ELR24908.1 - 1.3e-05 25.9 11.0 8.5e-05 23.3 11.0 2.0 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_2 PF02230.16 ELR24908.1 - 0.00012 22.0 0.0 0.001 18.9 0.0 2.2 3 0 0 3 3 3 1 Phospholipase/Carboxylesterase Abhydrolase_1 PF00561.20 ELR24908.1 - 0.00057 19.6 1.8 0.14 11.8 0.0 2.9 2 1 0 2 2 2 1 alpha/beta hydrolase fold DLH PF01738.18 ELR24908.1 - 0.0039 16.8 0.1 0.021 14.3 0.0 2.1 2 1 0 2 2 2 1 Dienelactone hydrolase family DUF915 PF06028.11 ELR24908.1 - 0.018 14.4 0.0 0.94 8.8 0.0 2.5 3 0 0 3 3 3 0 Alpha/beta hydrolase of unknown function (DUF915) Thioesterase PF00975.20 ELR24908.1 - 0.058 13.5 1.0 0.12 12.4 1.0 1.5 1 0 0 1 1 1 0 Thioesterase domain Esterase_phd PF10503.9 ELR24908.1 - 0.1 12.1 2.5 1.6 8.2 1.5 2.7 2 1 0 2 2 2 0 Esterase PHB depolymerase VIT PF08487.10 ELR24909.1 - 5.1e-31 107.2 0.0 1.2e-30 106.0 0.0 1.7 1 0 0 1 1 1 1 Vault protein inter-alpha-trypsin domain VWA_3 PF13768.6 ELR24909.1 - 7.1e-26 91.0 0.0 5.7e-22 78.3 0.0 2.4 2 0 0 2 2 2 2 von Willebrand factor type A domain VWA_2 PF13519.6 ELR24909.1 - 2.2e-11 44.3 0.0 5.9e-11 43.0 0.0 1.8 1 0 0 1 1 1 1 von Willebrand factor type A domain VIT_2 PF13757.6 ELR24909.1 - 2e-10 40.4 0.0 4.6e-10 39.3 0.0 1.5 1 0 0 1 1 1 1 Vault protein inter-alpha-trypsin domain VWA PF00092.28 ELR24909.1 - 4e-10 40.2 0.0 1.4e-09 38.5 0.0 1.9 1 1 0 1 1 1 1 von Willebrand factor type A domain zf-UBR PF02207.20 ELR24909.1 - 0.0024 18.0 7.6 0.0024 18.0 7.6 1.8 2 0 0 2 2 2 1 Putative zinc finger in N-recognin (UBR box) VWA_CoxE PF05762.14 ELR24909.1 - 0.005 16.2 0.0 0.01 15.3 0.0 1.4 1 0 0 1 1 1 1 VWA domain containing CoxE-like protein Ank PF00023.30 ELR24910.1 - 1.6e-18 66.3 0.6 4.6e-08 33.2 0.1 3.8 3 0 0 3 3 3 3 Ankyrin repeat Ank_2 PF12796.7 ELR24910.1 - 3.7e-18 65.9 0.1 2.6e-08 34.4 0.0 2.6 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ELR24910.1 - 1.7e-17 63.5 1.9 1.1e-06 29.0 0.1 2.7 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 ELR24910.1 - 2.9e-17 61.0 0.1 4e-06 26.8 0.0 3.6 3 0 0 3 3 3 3 Ankyrin repeat Ank_5 PF13857.6 ELR24910.1 - 8.8e-17 61.0 0.2 2.9e-09 37.0 0.0 2.6 1 1 1 2 2 2 2 Ankyrin repeats (many copies) zf-C3HC4_3 PF13920.6 ELR24910.1 - 6.7e-13 48.3 7.9 1e-12 47.7 7.9 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) STI1 PF17830.1 ELR24910.1 - 3.6e-07 30.0 0.0 9.4e-07 28.7 0.0 1.7 1 0 0 1 1 1 1 STI1 domain zf-C3HC4 PF00097.25 ELR24910.1 - 2.9e-05 23.9 10.9 4.6e-05 23.2 10.9 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 ELR24910.1 - 0.00017 21.4 8.6 0.0003 20.6 8.6 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_2 PF13639.6 ELR24910.1 - 0.00073 19.8 9.8 0.0012 19.1 9.8 1.3 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 ELR24910.1 - 0.0029 17.4 10.5 0.0048 16.7 10.5 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ELR24910.1 - 0.0056 16.6 8.0 0.0093 15.9 8.0 1.4 1 0 0 1 1 1 1 zinc-RING finger domain Cys_rich_CPXG PF14255.6 ELR24910.1 - 0.026 14.4 1.3 0.066 13.1 1.3 1.6 1 0 0 1 1 1 0 Cysteine-rich CPXCG ProRS-C_1 PF09180.11 ELR24910.1 - 0.093 12.9 1.9 0.23 11.7 1.9 1.7 1 0 0 1 1 1 0 Prolyl-tRNA synthetase, C-terminal zf-C3HC4_4 PF15227.6 ELR24910.1 - 0.75 10.0 8.6 1.4 9.1 8.6 1.5 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-P11 PF03854.14 ELR24910.1 - 1.8 8.3 7.2 3 7.6 7.2 1.3 1 0 0 1 1 1 0 P-11 zinc finger zf-RING_UBOX PF13445.6 ELR24910.1 - 2 8.5 5.6 5 7.2 5.5 1.8 1 1 0 1 1 1 0 RING-type zinc-finger FAM76 PF16046.5 ELR24910.1 - 7.9 5.7 17.2 0.0077 15.6 5.4 2.0 2 1 1 3 3 3 0 FAM76 protein TPR_17 PF13431.6 ELR24911.1 - 0.018 15.4 0.4 0.086 13.3 0.2 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat HflK_N PF12221.8 ELR24911.1 - 0.067 13.2 1.9 0.1 12.6 1.9 1.5 1 1 0 1 1 1 0 Bacterial membrane protein N terminal HAD_2 PF13419.6 ELR24912.1 - 5.3e-24 85.3 0.0 6.4e-24 85.0 0.0 1.1 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 ELR24912.1 - 1.2e-17 64.9 0.0 8.1e-17 62.2 0.0 1.9 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 ELR24912.1 - 0.00031 20.7 0.1 0.00061 19.8 0.1 1.4 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase_6 PF13344.6 ELR24912.1 - 0.0031 17.6 0.0 1.5 9.0 0.0 2.3 2 0 0 2 2 2 2 Haloacid dehalogenase-like hydrolase HAD PF12710.7 ELR24912.1 - 0.0089 16.4 0.1 0.043 14.2 0.1 2.2 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase TPR_2 PF07719.17 ELR24913.1 - 3.5e-11 42.3 0.0 2.5e-05 24.1 0.1 2.9 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.28 ELR24913.1 - 1.5e-08 34.1 0.0 0.00014 21.5 0.0 2.5 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.6 ELR24913.1 - 1.9e-07 30.8 0.2 0.012 15.8 0.0 3.2 3 0 0 3 3 2 2 Tetratricopeptide repeat TPR_14 PF13428.6 ELR24913.1 - 2e-07 31.2 0.1 0.013 16.3 0.0 2.8 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_9 PF13371.6 ELR24913.1 - 6.8e-07 29.4 0.2 1.6e-06 28.2 0.2 1.7 1 1 0 1 1 1 1 Tetratricopeptide repeat TPR_17 PF13431.6 ELR24913.1 - 2e-06 27.8 0.6 0.048 14.1 0.0 3.4 4 0 0 4 4 3 2 Tetratricopeptide repeat TPR_19 PF14559.6 ELR24913.1 - 3.9e-06 27.3 0.1 2e-05 25.0 0.0 2.3 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_11 PF13414.6 ELR24913.1 - 8.9e-06 25.3 0.1 0.00057 19.5 0.0 2.5 1 1 1 2 2 2 2 TPR repeat TPR_16 PF13432.6 ELR24913.1 - 5.4e-05 23.8 0.5 0.00015 22.3 0.0 2.1 2 1 0 2 2 1 1 Tetratricopeptide repeat TPR_12 PF13424.6 ELR24913.1 - 5.7e-05 23.3 0.1 0.0022 18.2 0.1 2.3 1 1 0 1 1 1 1 Tetratricopeptide repeat TPR_7 PF13176.6 ELR24913.1 - 0.00028 20.7 0.2 0.17 12.0 0.0 3.1 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_6 PF13174.6 ELR24913.1 - 0.00036 21.0 1.7 3.7 8.4 0.0 4.2 5 0 0 5 5 4 1 Tetratricopeptide repeat NARP1 PF12569.8 ELR24913.1 - 0.0015 17.5 0.0 0.0023 16.9 0.0 1.3 1 0 0 1 1 1 1 NMDA receptor-regulated protein 1 ANAPC3 PF12895.7 ELR24913.1 - 0.0081 16.4 0.0 0.048 13.9 0.0 2.1 1 1 1 2 2 2 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_10 PF13374.6 ELR24913.1 - 0.0092 15.8 0.2 0.2 11.6 0.1 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat BTAD PF03704.17 ELR24913.1 - 0.043 14.2 0.3 0.12 12.8 0.2 1.8 1 1 1 2 2 2 0 Bacterial transcriptional activator domain TPR_4 PF07721.14 ELR24913.1 - 0.67 10.7 6.7 1.5 9.7 0.6 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat EFG_IV PF03764.18 ELR24914.1 - 2.2e-17 62.9 0.0 4.9e-17 61.8 0.0 1.6 1 0 0 1 1 1 1 Elongation factor G, domain IV EFG_C PF00679.24 ELR24914.1 - 7.8e-13 48.3 0.0 1.7e-12 47.2 0.0 1.6 1 0 0 1 1 1 1 Elongation factor G C-terminus EFG_II PF14492.6 ELR24914.1 - 2e-09 37.4 0.0 4.2e-09 36.4 0.0 1.5 1 0 0 1 1 1 1 Elongation Factor G, domain II GTP_EFTU_D2 PF03144.25 ELR24914.1 - 2.3e-07 31.1 0.0 4.4e-07 30.2 0.0 1.4 1 0 0 1 1 1 1 Elongation factor Tu domain 2 Ras PF00071.22 ELR24915.1 - 3.3e-24 85.3 0.0 1.7e-13 50.5 0.0 2.2 2 0 0 2 2 2 2 Ras family Roc PF08477.13 ELR24915.1 - 2.8e-06 27.6 0.0 3.4e-05 24.0 0.0 2.2 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase DUF4128 PF13554.6 ELR24915.1 - 0.062 13.4 0.0 0.13 12.4 0.0 1.4 1 0 0 1 1 1 0 Bacteriophage related domain of unknown function F-box-like PF12937.7 ELR24916.1 - 4e-08 33.0 0.8 8.1e-08 32.0 0.8 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ELR24916.1 - 5.8e-05 22.9 0.2 0.00012 21.8 0.2 1.6 1 0 0 1 1 1 1 F-box domain F-box_4 PF15966.5 ELR24916.1 - 0.033 14.1 0.0 0.12 12.3 0.0 1.9 2 0 0 2 2 2 0 F-box IMUP PF15761.5 ELR24916.1 - 0.055 14.2 6.3 0.098 13.4 6.3 1.5 1 0 0 1 1 1 0 Immortalisation up-regulated protein FAM176 PF14851.6 ELR24916.1 - 4.2 7.0 6.9 3.6 7.3 5.8 1.5 1 1 0 1 1 1 0 FAM176 family Acyl_transf_3 PF01757.22 ELR24917.1 - 2.2e-07 30.3 46.1 1e-06 28.1 23.2 2.3 2 0 0 2 2 2 2 Acyltransferase family Zip PF02535.22 ELR24918.1 - 0.01 15.1 0.7 0.012 14.8 0.7 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Nop14 PF04147.12 ELR24918.1 - 0.13 10.5 25.5 0.15 10.2 25.5 1.0 1 0 0 1 1 1 0 Nop14-like family Nop53 PF07767.11 ELR24918.1 - 0.69 9.2 17.4 0.81 9.0 17.4 1.0 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) FAM176 PF14851.6 ELR24918.1 - 0.81 9.3 16.3 0.077 12.7 0.8 2.1 1 1 1 2 2 2 0 FAM176 family CDC45 PF02724.14 ELR24918.1 - 1.4 7.1 24.1 1.7 6.9 24.1 1.0 1 0 0 1 1 1 0 CDC45-like protein Vfa1 PF08432.10 ELR24918.1 - 3.7 7.8 14.1 4.8 7.5 14.1 1.1 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Methyltransf_11 PF08241.12 ELR24919.1 - 5.6e-09 36.5 0.0 2.2e-06 28.2 0.0 2.2 1 1 1 2 2 2 2 Methyltransferase domain Methyltransf_31 PF13847.6 ELR24919.1 - 4e-07 30.0 0.0 0.022 14.5 0.0 2.2 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_25 PF13649.6 ELR24919.1 - 4.1e-07 30.6 0.0 0.0021 18.7 0.0 2.8 2 1 0 2 2 2 2 Methyltransferase domain Methyltransf_12 PF08242.12 ELR24919.1 - 0.00034 21.3 0.0 0.0019 18.9 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_32 PF13679.6 ELR24919.1 - 0.0069 16.4 0.0 0.0085 16.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 ELR24919.1 - 0.029 13.7 0.0 0.21 10.9 0.0 2.2 2 0 0 2 2 2 0 ubiE/COQ5 methyltransferase family MTS PF05175.14 ELR24919.1 - 0.1 12.1 0.0 0.91 9.0 0.0 2.1 2 1 0 2 2 2 0 Methyltransferase small domain TRAPP PF04051.16 ELR24920.1 - 6.3e-33 113.5 0.0 7.8e-33 113.3 0.0 1.1 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component FYVE PF01363.21 ELR24921.1 - 3.4e-11 43.1 13.8 3.4e-11 43.1 13.8 1.7 2 0 0 2 2 2 1 FYVE zinc finger SMYLE_N PF18615.1 ELR24921.1 - 3.9e-05 23.4 12.0 0.0071 16.0 0.9 2.5 2 1 0 2 2 2 2 Short myomegalin-like EB1 binding proteins, N-terminal domain FYVE_2 PF02318.16 ELR24921.1 - 4.6 7.5 12.3 2.9 8.1 8.8 2.4 2 1 1 3 3 3 0 FYVE-type zinc finger Vpu PF00558.19 ELR24921.1 - 8.9 6.2 0.0 8.9 6.2 0.0 4.0 4 2 0 4 4 4 0 Vpu protein CN_hydrolase PF00795.22 ELR24922.1 - 4.1e-43 147.6 0.0 5.5e-43 147.2 0.0 1.0 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase GTP_EFTU PF00009.27 ELR24923.1 - 1.7e-17 63.6 0.0 2.5e-17 63.1 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_IV PF03764.18 ELR24923.1 - 9e-17 61.0 0.0 4.6e-16 58.7 0.0 2.2 3 0 0 3 3 3 1 Elongation factor G, domain IV EFG_C PF00679.24 ELR24923.1 - 1.8e-10 40.7 0.0 3e-09 36.8 0.0 2.6 1 1 0 1 1 1 1 Elongation factor G C-terminus CPBP PF02517.16 ELR24924.1 - 2.3e-09 37.5 23.0 6.5e-07 29.6 23.0 3.0 1 1 0 1 1 1 1 CPBP intramembrane metalloprotease AAA PF00004.29 ELR24925.1 - 6.2e-83 275.8 0.0 1.7e-40 138.5 0.0 2.3 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 ELR24925.1 - 2.1e-28 97.9 1.1 7.3e-13 48.1 0.3 2.6 2 0 0 2 2 2 2 AAA+ lid domain AAA_2 PF07724.14 ELR24925.1 - 1.5e-14 54.4 0.0 3.1e-06 27.4 0.0 2.5 2 0 0 2 2 2 2 AAA domain (Cdc48 subfamily) AAA_5 PF07728.14 ELR24925.1 - 1.6e-12 47.6 0.2 1.7e-05 24.8 0.1 3.6 2 2 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 ELR24925.1 - 2.5e-12 47.5 0.4 3.8e-05 24.1 0.1 3.8 2 1 0 2 2 2 2 AAA ATPase domain TIP49 PF06068.13 ELR24925.1 - 5.8e-12 45.5 0.0 2.7e-05 23.5 0.0 2.4 2 0 0 2 2 2 2 TIP49 P-loop domain RuvB_N PF05496.12 ELR24925.1 - 1.5e-09 37.8 0.0 0.00045 20.0 0.0 2.9 2 1 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_14 PF13173.6 ELR24925.1 - 4.8e-09 36.3 0.0 0.0026 17.8 0.0 2.3 2 0 0 2 2 2 2 AAA domain AAA_22 PF13401.6 ELR24925.1 - 6.4e-09 36.2 2.1 0.0067 16.7 0.2 4.5 2 2 1 3 3 3 2 AAA domain ABC_tran PF00005.27 ELR24925.1 - 4.1e-07 30.6 0.0 0.046 14.2 0.0 2.8 2 0 0 2 2 2 2 ABC transporter AAA_18 PF13238.6 ELR24925.1 - 4.2e-07 30.6 0.0 0.0012 19.3 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_33 PF13671.6 ELR24925.1 - 9.8e-07 29.0 0.0 0.033 14.3 0.0 3.1 3 0 0 3 3 2 2 AAA domain NACHT PF05729.12 ELR24925.1 - 2.6e-06 27.5 1.2 0.86 9.5 0.0 3.6 3 0 0 3 3 3 2 NACHT domain Sigma54_activat PF00158.26 ELR24925.1 - 7.9e-06 25.7 0.0 0.19 11.4 0.0 3.4 2 1 0 2 2 2 2 Sigma-54 interaction domain IstB_IS21 PF01695.17 ELR24925.1 - 1e-05 25.4 0.0 0.041 13.6 0.0 2.5 2 0 0 2 2 2 2 IstB-like ATP binding protein AAA_17 PF13207.6 ELR24925.1 - 2.6e-05 24.6 0.0 0.14 12.6 0.0 2.7 2 0 0 2 2 2 2 AAA domain RNA_helicase PF00910.22 ELR24925.1 - 3.1e-05 24.3 0.0 0.11 12.9 0.0 2.7 2 0 0 2 2 2 2 RNA helicase TsaE PF02367.17 ELR24925.1 - 3.8e-05 23.7 0.0 0.34 10.9 0.0 2.9 3 0 0 3 3 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_7 PF12775.7 ELR24925.1 - 4.8e-05 22.9 0.0 0.11 12.0 0.0 2.6 2 1 0 2 2 2 2 P-loop containing dynein motor region AAA_28 PF13521.6 ELR24925.1 - 6.1e-05 23.3 0.0 0.15 12.3 0.0 2.7 2 0 0 2 2 2 2 AAA domain Mg_chelatase PF01078.21 ELR24925.1 - 9.8e-05 21.8 0.2 0.15 11.4 0.0 2.5 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI Cytidylate_kin PF02224.18 ELR24925.1 - 0.00018 21.3 0.2 0.44 10.2 0.0 2.4 2 0 0 2 2 2 2 Cytidylate kinase AAA_29 PF13555.6 ELR24925.1 - 0.00023 20.9 0.0 0.15 11.8 0.0 2.5 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_25 PF13481.6 ELR24925.1 - 0.0003 20.4 2.8 1.6 8.3 0.0 3.9 3 1 1 4 4 4 1 AAA domain AAA_24 PF13479.6 ELR24925.1 - 0.00043 20.1 0.0 0.6 9.8 0.0 2.4 2 0 0 2 2 2 2 AAA domain Viral_helicase1 PF01443.18 ELR24925.1 - 0.00068 19.5 0.0 0.071 12.8 0.0 2.3 2 0 0 2 2 2 1 Viral (Superfamily 1) RNA helicase AAA_3 PF07726.11 ELR24925.1 - 0.001 18.9 0.0 1.5 8.6 0.0 2.8 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) NB-ARC PF00931.22 ELR24925.1 - 0.0012 18.1 0.0 0.83 8.8 0.0 2.5 2 0 0 2 2 2 1 NB-ARC domain AAA_30 PF13604.6 ELR24925.1 - 0.0016 18.2 0.0 0.42 10.3 0.0 2.7 2 0 0 2 2 2 1 AAA domain Rad17 PF03215.15 ELR24925.1 - 0.0023 17.9 0.0 1.2 9.0 0.0 2.3 2 0 0 2 2 2 1 Rad17 P-loop domain NTPase_1 PF03266.15 ELR24925.1 - 0.005 16.8 1.3 0.74 9.7 0.0 3.4 2 2 2 4 4 4 1 NTPase AAA_19 PF13245.6 ELR24925.1 - 0.0055 17.1 0.5 1.2 9.5 0.0 3.0 3 1 0 3 3 2 1 AAA domain AFG1_ATPase PF03969.16 ELR24925.1 - 0.0079 15.1 0.2 0.22 10.4 0.1 2.9 2 1 0 2 2 2 1 AFG1-like ATPase AAA_23 PF13476.6 ELR24925.1 - 0.012 16.2 0.1 0.087 13.3 0.0 2.2 2 0 0 2 2 2 0 AAA domain Zeta_toxin PF06414.12 ELR24925.1 - 0.015 14.6 0.1 0.73 9.1 0.0 2.4 2 0 0 2 2 2 0 Zeta toxin CPT PF07931.12 ELR24925.1 - 0.022 14.6 0.0 0.51 10.1 0.0 2.5 2 1 0 2 2 2 0 Chloramphenicol phosphotransferase-like protein ATPase PF06745.13 ELR24925.1 - 0.023 14.0 0.3 9.7 5.5 0.1 3.2 3 0 0 3 3 3 0 KaiC TniB PF05621.11 ELR24925.1 - 0.029 13.8 0.0 10 5.5 0.0 3.4 4 0 0 4 4 3 0 Bacterial TniB protein ResIII PF04851.15 ELR24925.1 - 0.029 14.4 0.0 11 6.0 0.0 2.8 2 1 0 2 2 2 0 Type III restriction enzyme, res subunit DUF815 PF05673.13 ELR24925.1 - 0.037 13.2 0.0 0.79 8.8 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF815) Sigma54_activ_2 PF14532.6 ELR24925.1 - 0.1 12.7 0.0 6.7 6.8 0.0 2.5 2 0 0 2 2 2 0 Sigma-54 interaction domain RsgA_GTPase PF03193.16 ELR24925.1 - 0.12 12.3 0.0 15 5.4 0.0 2.6 2 0 0 2 2 2 0 RsgA GTPase AAA_8 PF12780.7 ELR24925.1 - 0.12 11.7 0.0 2.2 7.5 0.0 2.2 2 0 0 2 2 2 0 P-loop containing dynein motor region D4 GxGYxYP_N PF16216.5 ELR24925.1 - 0.13 12.5 0.0 5 7.2 0.0 2.3 2 0 0 2 2 2 0 GxGYxY sequence motif in domain of unknown function N-terminal SKI PF01202.22 ELR24925.1 - 0.16 12.1 0.2 7.1 6.7 0.0 2.4 2 0 0 2 2 2 0 Shikimate kinase PhoH PF02562.16 ELR24925.1 - 0.17 11.3 0.1 23 4.4 0.0 2.3 2 0 0 2 2 2 0 PhoH-like protein Hydin_ADK PF17213.3 ELR24925.1 - 4.2 7.6 7.7 35 4.6 0.0 4.5 5 0 0 5 5 5 0 Hydin Adenylate kinase-like domain RRM_1 PF00076.22 ELR24926.1 - 7.5e-10 38.5 0.0 1e-09 38.0 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-CCHC PF00098.23 ELR24926.1 - 1.3e-08 34.6 1.9 2.6e-08 33.6 1.9 1.6 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_5 PF14787.6 ELR24926.1 - 0.00047 19.8 2.8 0.0013 18.4 2.8 1.8 1 0 0 1 1 1 1 GAG-polyprotein viral zinc-finger zf-CCHC_2 PF13696.6 ELR24926.1 - 0.0015 18.3 1.2 0.0031 17.3 1.2 1.5 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_3 PF13917.6 ELR24926.1 - 0.017 15.1 0.7 0.037 14.0 0.7 1.5 1 0 0 1 1 1 0 Zinc knuckle Nup35_RRM_2 PF14605.6 ELR24926.1 - 0.086 12.9 0.1 0.14 12.1 0.1 1.3 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif RRM_5 PF13893.6 ELR24926.1 - 0.2 11.2 0.0 0.32 10.6 0.0 1.3 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PARP PF00644.20 ELR24927.1 - 8.2e-20 71.2 0.1 2.6e-19 69.6 0.1 1.9 1 1 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain WWE PF02825.20 ELR24927.1 - 1.1e-11 45.2 5.2 1.2e-10 41.9 3.6 2.6 2 0 0 2 2 2 1 WWE domain KH_1 PF00013.29 ELR24927.1 - 1.7e-08 34.1 0.0 0.00026 20.8 0.0 2.5 2 0 0 2 2 2 2 KH domain SLS PF14611.6 ELR24927.1 - 0.0026 17.6 0.4 0.14 11.9 0.1 2.4 1 1 1 2 2 2 2 Mitochondrial inner-membrane-bound regulator DAGK_cat PF00781.24 ELR24928.1 - 3.5e-30 104.2 0.0 6.1e-30 103.4 0.0 1.4 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain D123 PF07065.14 ELR24929.1 - 6.5e-22 78.1 0.0 5.1e-19 68.5 0.0 2.4 2 0 0 2 2 2 2 D123 R2K_2 PF18299.1 ELR24929.1 - 2.6e-06 27.4 0.1 2.6e-05 24.1 0.1 2.2 2 0 0 2 2 2 1 ATP-grasp domain, R2K clade family 2 R2K_3 PF14243.6 ELR24929.1 - 0.00013 22.0 0.1 0.00032 20.8 0.1 1.6 1 0 0 1 1 1 1 ATP-grasp domain, R2K clade family 3 2Fe-2S_Ferredox PF11591.8 ELR24929.1 - 0.0097 15.7 1.1 0.024 14.5 1.1 1.6 1 0 0 1 1 1 1 Ferredoxin chloroplastic transit peptide Peptidase_S46 PF10459.9 ELR24929.1 - 1.8 7.1 4.0 2.4 6.7 4.0 1.2 1 0 0 1 1 1 0 Peptidase S46 LRR_9 PF14580.6 ELR24930.1 - 5.5e-11 42.3 6.5 3.7e-06 26.6 1.1 2.3 1 1 1 2 2 2 2 Leucine-rich repeat LRR_4 PF12799.7 ELR24930.1 - 1.7e-09 37.8 24.5 0.00018 21.8 5.2 4.4 3 1 2 5 5 5 5 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 ELR24930.1 - 5.8e-06 26.0 27.9 0.039 13.7 10.4 4.2 1 1 1 3 3 3 3 Leucine rich repeat LRR_6 PF13516.6 ELR24930.1 - 0.24 11.6 11.0 20 5.6 0.0 4.8 5 1 0 5 5 5 0 Leucine Rich repeat LRR_1 PF00560.33 ELR24930.1 - 1 10.1 19.1 10 7.1 0.4 5.8 5 0 0 5 5 5 0 Leucine Rich Repeat Sel1 PF08238.12 ELR24931.1 - 7.9e-13 48.6 11.8 0.00056 20.5 0.2 5.5 4 1 1 5 5 5 4 Sel1 repeat Ank_2 PF12796.7 ELR24933.1 - 1.1e-28 99.6 0.3 8.6e-15 55.1 0.2 2.1 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ELR24933.1 - 1.1e-28 99.2 2.3 6.1e-14 52.2 0.0 2.7 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.30 ELR24933.1 - 2.3e-22 78.4 0.7 4.4e-07 30.0 0.2 3.3 3 0 0 3 3 3 3 Ankyrin repeat Ank_3 PF13606.6 ELR24933.1 - 3.9e-20 69.8 0.2 4.5e-05 23.5 0.1 3.8 4 0 0 4 4 4 3 Ankyrin repeat Ank_5 PF13857.6 ELR24933.1 - 2.9e-19 68.9 1.1 5e-07 29.9 0.2 3.1 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Arm PF00514.23 ELR24934.1 - 1.3e-06 28.3 0.8 0.00016 21.6 0.0 2.7 2 1 0 2 2 2 2 Armadillo/beta-catenin-like repeat WAPL PF07814.13 ELR24934.1 - 2.6e-05 23.2 0.0 3.6e-05 22.7 0.0 1.1 1 0 0 1 1 1 1 Wings apart-like protein regulation of heterochromatin Pkinase_Tyr PF07714.17 ELR24935.1 - 2e-38 132.1 0.0 4.4e-18 65.5 0.0 2.2 1 1 1 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 ELR24935.1 - 3.3e-25 89.0 0.0 2.3e-13 50.1 0.0 2.2 1 1 1 2 2 2 2 Protein kinase domain SAM_2 PF07647.17 ELR24935.1 - 1.7e-10 40.8 0.0 2.9e-10 40.1 0.0 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 ELR24935.1 - 4.4e-08 33.4 0.0 8.5e-08 32.5 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) YEATS PF03366.16 ELR24935.1 - 0.0017 18.3 0.0 0.11 12.4 0.0 2.4 1 1 1 2 2 2 1 YEATS family SAM_Ste50p PF09235.10 ELR24935.1 - 0.052 13.8 0.0 0.14 12.4 0.0 1.7 1 0 0 1 1 1 0 Ste50p, sterile alpha motif SOG2 PF10428.9 ELR24935.1 - 8 5.5 17.9 7 5.7 1.0 2.2 2 0 0 2 2 2 0 RAM signalling pathway protein PhyH PF05721.13 ELR24937.1 - 1.2e-15 58.4 0.0 2e-15 57.6 0.0 1.4 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) TPR_2 PF07719.17 ELR24937.1 - 0.0026 17.7 1.4 0.0082 16.2 1.4 1.8 1 0 0 1 1 1 1 Tetratricopeptide repeat 2OG-FeII_Oxy_5 PF13759.6 ELR24937.1 - 0.0059 17.0 0.0 0.015 15.7 0.0 1.7 1 0 0 1 1 1 1 Putative 2OG-Fe(II) oxygenase TPR_1 PF00515.28 ELR24937.1 - 0.0089 15.8 0.7 0.0089 15.8 0.7 1.8 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.6 ELR24937.1 - 0.0096 16.7 0.0 0.04 14.8 0.0 2.1 1 0 0 1 1 1 1 Tetratricopeptide repeat TMEM252 PF15664.5 ELR24937.1 - 0.011 15.5 0.0 0.022 14.5 0.0 1.4 1 0 0 1 1 1 0 Transmembrane protein 252 family Cupin_2 PF07883.11 ELR24937.1 - 0.036 13.8 0.0 0.079 12.7 0.0 1.5 1 0 0 1 1 1 0 Cupin domain TPR_7 PF13176.6 ELR24937.1 - 0.065 13.3 0.1 0.2 11.8 0.1 1.8 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_16 PF13432.6 ELR24937.1 - 0.14 12.8 0.8 0.33 11.7 0.5 1.7 2 0 0 2 2 2 0 Tetratricopeptide repeat Bin3 PF06859.12 ELR24939.1 - 2.5e-37 127.8 0.8 3.1e-35 121.1 0.0 2.6 1 1 1 2 2 2 1 Bicoid-interacting protein 3 (Bin3) Methyltransf_23 PF13489.6 ELR24939.1 - 7.5e-15 55.2 0.1 1.1e-14 54.6 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ELR24939.1 - 5.8e-12 46.2 0.1 1.9e-09 38.1 0.1 2.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ELR24939.1 - 1.9e-10 41.3 0.0 3.1e-05 24.6 0.0 2.3 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_31 PF13847.6 ELR24939.1 - 5.1e-10 39.4 0.0 1.3e-05 25.0 0.0 2.2 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_11 PF08241.12 ELR24939.1 - 3.2e-08 34.1 0.0 0.0019 18.8 0.0 2.4 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_18 PF12847.7 ELR24939.1 - 0.00031 20.7 0.0 0.00082 19.3 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain PCMT PF01135.19 ELR24939.1 - 0.00056 19.7 0.0 0.0014 18.4 0.0 1.6 2 0 0 2 2 2 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) MTS PF05175.14 ELR24939.1 - 0.00098 18.7 0.0 0.0073 15.9 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase small domain PrmA PF06325.13 ELR24939.1 - 0.0017 17.8 0.0 0.0043 16.5 0.0 1.6 2 0 0 2 2 2 1 Ribosomal protein L11 methyltransferase (PrmA) CMAS PF02353.20 ELR24939.1 - 0.0036 16.6 0.0 0.2 10.9 0.0 2.1 2 0 0 2 2 2 1 Mycolic acid cyclopropane synthetase Methyltransf_4 PF02390.17 ELR24939.1 - 0.0041 16.6 0.0 0.026 14.0 0.0 2.2 2 0 0 2 2 2 1 Putative methyltransferase CheR PF01739.18 ELR24939.1 - 0.007 15.9 0.0 0.78 9.2 0.0 2.2 2 0 0 2 2 2 1 CheR methyltransferase, SAM binding domain Methyltransf_32 PF13679.6 ELR24939.1 - 0.012 15.6 0.1 0.012 15.6 0.1 1.8 2 0 0 2 2 2 0 Methyltransferase domain DUF1963 PF09234.10 ELR24939.1 - 0.023 15.2 0.8 0.042 14.3 0.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1963) Methyltransf_2 PF00891.18 ELR24939.1 - 0.11 11.7 0.0 1.5 8.0 0.0 2.1 2 0 0 2 2 2 0 O-methyltransferase domain Zip PF02535.22 ELR24939.1 - 7.4 5.7 4.4 28 3.8 0.1 2.1 2 0 0 2 2 2 0 ZIP Zinc transporter Sugar_tr PF00083.24 ELR24940.1 - 2.4e-119 399.2 25.9 2.8e-119 399.0 25.9 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 ELR24940.1 - 9.3e-26 90.6 38.8 1.3e-18 67.1 16.2 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily OATP PF03137.20 ELR24940.1 - 0.16 10.2 9.0 0.0076 14.6 2.7 1.8 2 1 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family SlyX PF04102.12 ELR24942.1 - 0.0032 18.0 5.2 0.0069 17.0 2.2 2.3 1 1 1 2 2 2 1 SlyX DUF3584 PF12128.8 ELR24942.1 - 0.054 11.0 5.4 0.065 10.7 5.4 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Spc7 PF08317.11 ELR24942.1 - 0.055 12.3 3.3 0.071 12.0 3.3 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein GAS PF13851.6 ELR24942.1 - 0.08 12.3 5.4 0.11 11.9 5.4 1.1 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding Phage_HK97_TLTM PF06120.11 ELR24942.1 - 0.1 11.8 2.5 0.13 11.4 2.5 1.1 1 0 0 1 1 1 0 Tail length tape measure protein DUF4201 PF13870.6 ELR24942.1 - 0.28 10.9 7.0 0.38 10.5 7.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4201) Peptidase_M3 PF01432.20 ELR24942.1 - 0.48 9.6 2.9 0.58 9.3 2.9 1.0 1 0 0 1 1 1 0 Peptidase family M3 DSBA PF01323.20 ELR24944.1 - 0.0041 16.9 2.1 0.078 12.8 0.2 2.5 2 1 0 2 2 2 2 DSBA-like thioredoxin domain Spt20 PF12090.8 ELR24944.1 - 0.59 9.7 7.9 0.89 9.1 7.9 1.2 1 0 0 1 1 1 0 Spt20 family PDE4_UCR PF18100.1 ELR24944.1 - 0.68 10.6 0.0 0.68 10.6 0.0 2.9 2 1 1 3 3 3 0 Phosphodiesterase 4 upstream conserved regions (UCR) BAR PF03114.18 ELR24945.1 - 4.9e-23 82.0 8.5 7.1e-23 81.5 8.5 1.2 1 0 0 1 1 1 1 BAR domain SH3_2 PF07653.17 ELR24945.1 - 6.5e-13 48.1 0.0 1.2e-12 47.3 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.6 ELR24945.1 - 6.7e-12 45.1 0.0 1.4e-11 44.0 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain BAR_3 PF16746.5 ELR24945.1 - 4.3e-10 39.7 3.7 7.3e-10 39.0 3.7 1.3 1 0 0 1 1 1 1 BAR domain of APPL family SH3_1 PF00018.28 ELR24945.1 - 7.7e-09 35.0 0.0 1.6e-08 34.1 0.0 1.5 1 0 0 1 1 1 1 SH3 domain BAR_2 PF10455.9 ELR24945.1 - 1.5e-08 34.1 3.9 2.2e-08 33.6 3.9 1.1 1 0 0 1 1 1 1 Bin/amphiphysin/Rvs domain for vesicular trafficking Rad9 PF04139.13 ELR24946.1 - 2e-58 197.8 0.3 2.7e-58 197.4 0.3 1.1 1 0 0 1 1 1 1 Rad9 SPX PF03105.19 ELR24946.1 - 0.17 11.8 5.6 0.2 11.6 5.6 1.2 1 0 0 1 1 1 0 SPX domain Hamartin PF04388.12 ELR24946.1 - 2.8 6.5 9.6 3.7 6.1 9.6 1.1 1 0 0 1 1 1 0 Hamartin protein RhoGEF PF00621.20 ELR24947.1 - 1.4e-48 165.5 0.4 2.6e-48 164.7 0.4 1.4 1 0 0 1 1 1 1 RhoGEF domain PH PF00169.29 ELR24947.1 - 5.4e-05 23.6 0.0 0.00011 22.7 0.0 1.5 1 0 0 1 1 1 1 PH domain PH_10 PF15411.6 ELR24947.1 - 0.0022 18.2 0.6 0.016 15.4 0.2 2.2 1 1 0 2 2 2 1 Pleckstrin homology domain IQ_SEC7_PH PF16453.5 ELR24947.1 - 0.094 12.7 0.1 0.26 11.2 0.1 1.8 1 0 0 1 1 1 0 PH domain FYRC PF05965.14 ELR24947.1 - 0.12 12.6 0.4 0.63 10.2 0.0 2.3 3 0 0 3 3 3 0 F/Y rich C-terminus PKD_channel PF08016.12 ELR24949.1 - 0.052 12.2 0.1 0.087 11.5 0.1 1.2 1 0 0 1 1 1 0 Polycystin cation channel RhoGAP PF00620.27 ELR24950.1 - 6.6e-23 81.2 0.1 4.8e-21 75.2 0.1 2.4 1 1 0 1 1 1 1 RhoGAP domain SAPS PF04499.15 ELR24950.1 - 0.0027 16.6 15.2 0.0037 16.1 15.2 1.2 1 0 0 1 1 1 1 SIT4 phosphatase-associated protein Nop14 PF04147.12 ELR24950.1 - 1.4 7.0 31.9 1.7 6.7 31.9 1.1 1 0 0 1 1 1 0 Nop14-like family DUF2828 PF11443.8 ELR24950.1 - 1.5 6.8 15.2 2.7 6.0 15.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) Hid1 PF12722.7 ELR24950.1 - 7.6 4.5 12.4 13 3.7 12.4 1.3 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein UQ_con PF00179.26 ELR24951.1 - 4.4e-40 136.6 0.1 2.1e-28 98.8 0.0 2.0 1 1 1 2 2 2 2 Ubiquitin-conjugating enzyme DUF4055 PF13264.6 ELR24952.1 - 0.053 13.7 1.7 0.075 13.2 0.6 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4055) Allexi_40kDa PF05549.11 ELR24952.1 - 0.084 12.4 3.1 0.13 11.8 2.5 1.6 1 1 0 1 1 1 0 Allexivirus 40kDa protein DUF3450 PF11932.8 ELR24952.1 - 0.12 11.7 10.6 0.027 13.8 6.1 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) MSP1_C PF07462.11 ELR24952.1 - 0.15 10.7 1.8 0.2 10.3 0.3 1.8 2 0 0 2 2 2 0 Merozoite surface protein 1 (MSP1) C-terminus SlyX PF04102.12 ELR24952.1 - 0.23 12.1 15.8 0.088 13.4 8.9 3.3 2 1 0 2 2 2 0 SlyX Med11 PF10280.9 ELR24952.1 - 2.1 8.8 11.9 2.3 8.7 9.1 2.6 2 1 0 2 2 2 0 Mediator complex protein Sec2p PF06428.11 ELR24952.1 - 2.8 8.0 16.9 0.06 13.3 4.6 3.2 3 0 0 3 3 3 0 GDP/GTP exchange factor Sec2p Csm1_N PF18504.1 ELR24952.1 - 3 8.2 8.2 0.56 10.6 3.4 2.4 2 0 0 2 2 2 0 Csm1 N-terminal domain BLOC1_2 PF10046.9 ELR24952.1 - 3.5 8.0 7.4 1.6 9.1 1.3 3.0 4 0 0 4 4 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 HeLo PF14479.6 ELR24953.1 - 0.0078 16.1 4.8 0.04 13.8 0.5 2.3 2 0 0 2 2 2 1 Prion-inhibition and propagation PCEMA1 PF07418.11 ELR24953.1 - 0.098 12.2 6.2 0.023 14.2 2.1 1.9 2 0 0 2 2 2 0 Acidic phosphoprotein precursor PCEMA1 Glyco_tranf_2_4 PF13704.6 ELR24953.1 - 0.27 11.8 4.4 1.7 9.2 0.3 2.8 2 1 0 2 2 2 0 Glycosyl transferase family 2 APG6_N PF17675.1 ELR24953.1 - 4.4 7.8 14.9 22 5.6 11.7 2.9 2 1 0 2 2 2 0 Apg6 coiled-coil region DUF4164 PF13747.6 ELR24953.1 - 7.8 6.8 14.3 0.5 10.7 6.9 2.7 3 1 0 3 3 3 0 Domain of unknown function (DUF4164) LRR_8 PF13855.6 ELR24954.1 - 1.9e-47 158.9 47.3 4.2e-11 42.4 1.3 7.9 3 2 6 9 9 9 9 Leucine rich repeat LRR_4 PF12799.7 ELR24954.1 - 8e-34 115.1 57.4 1.5e-05 25.2 0.3 10.1 6 2 2 10 10 10 9 Leucine Rich repeats (2 copies) SAM_1 PF00536.30 ELR24954.1 - 1.3e-09 38.4 0.0 3e-09 37.2 0.0 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) LRR_1 PF00560.33 ELR24954.1 - 1.3e-06 28.2 42.9 3.2 8.7 0.0 13.9 17 1 0 17 17 14 2 Leucine Rich Repeat LRR_9 PF14580.6 ELR24954.1 - 1.3e-06 28.0 28.3 0.021 14.4 2.7 5.3 1 1 5 6 6 6 5 Leucine-rich repeat SAM_2 PF07647.17 ELR24954.1 - 4.3e-06 26.8 0.1 0.00012 22.1 0.0 3.4 4 0 0 4 4 4 1 SAM domain (Sterile alpha motif) F-box PF00646.33 ELR24954.1 - 9.4e-06 25.4 3.8 0.00021 21.0 0.0 3.0 3 0 0 3 3 3 1 F-box domain F-box-like PF12937.7 ELR24954.1 - 0.0006 19.6 1.8 0.0018 18.1 0.0 2.8 2 0 0 2 2 2 1 F-box-like FAP PF07174.11 ELR24954.1 - 0.047 13.1 1.9 0.069 12.6 0.9 1.6 2 0 0 2 2 2 0 Fibronectin-attachment protein (FAP) RsmF_methylt_CI PF17126.5 ELR24954.1 - 0.13 12.4 0.8 15 5.7 0.0 4.4 4 2 2 6 6 6 0 RsmF rRNA methyltransferase first C-terminal domain NosD PF05048.13 ELR24954.1 - 0.15 11.3 0.0 0.28 10.4 0.0 1.4 1 0 0 1 1 1 0 Periplasmic copper-binding protein (NosD) Macoilin PF09726.9 ELR24954.1 - 0.3 9.6 4.2 0.4 9.2 4.2 1.1 1 0 0 1 1 1 0 Macoilin family Mitofilin PF09731.9 ELR24954.1 - 0.42 9.4 13.2 0.64 8.8 13.2 1.2 1 0 0 1 1 1 0 Mitochondrial inner membrane protein LRR_6 PF13516.6 ELR24954.1 - 0.92 9.7 45.0 5 7.4 0.1 11.7 14 0 0 14 14 13 0 Leucine Rich repeat GREB1 PF15782.5 ELR24954.1 - 2.3 5.2 5.6 4 4.4 5.6 1.3 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer LRR_3 PF07725.12 ELR24954.1 - 3.2 7.8 19.4 22 5.1 0.0 7.4 8 0 0 8 8 8 0 Leucine Rich Repeat UCR_TM PF02921.14 ELR24955.1 - 6.5e-12 45.8 0.0 1.5e-11 44.6 0.0 1.6 1 0 0 1 1 1 1 Ubiquinol cytochrome reductase transmembrane region Rieske PF00355.26 ELR24955.1 - 6.8e-12 45.2 0.0 1.2e-11 44.3 0.0 1.4 1 1 0 1 1 1 1 Rieske [2Fe-2S] domain RasGEF PF00617.19 ELR24956.1 - 3.1e-75 252.2 1.4 3.1e-45 154.5 0.0 2.5 2 0 0 2 2 2 2 RasGEF domain RasGEF_N PF00618.20 ELR24956.1 - 6.4e-18 64.9 1.0 7.2e-13 48.7 0.3 3.3 3 0 0 3 3 3 2 RasGEF N-terminal motif Imm42 PF15593.6 ELR24956.1 - 0.022 15.2 0.3 0.24 11.9 0.1 2.6 2 0 0 2 2 2 0 Immunity protein 42 DUF4683 PF15735.5 ELR24956.1 - 0.025 14.2 0.3 0.076 12.6 0.3 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4683) Insulin_TMD PF17870.1 ELR24957.1 - 0.067 13.3 0.1 0.15 12.2 0.1 1.5 1 0 0 1 1 1 0 Insulin receptor trans-membrane segment Gram_pos_anchor PF00746.21 ELR24957.1 - 0.068 13.1 0.7 0.068 13.1 0.7 2.3 2 0 0 2 2 2 0 LPXTG cell wall anchor motif SPX PF03105.19 ELR24957.1 - 1 9.2 20.0 1.5 8.7 20.0 1.1 1 0 0 1 1 1 0 SPX domain Peptidase_S8 PF00082.22 ELR24958.1 - 4.1e-37 128.0 0.6 5e-37 127.8 0.6 1.1 1 0 0 1 1 1 1 Subtilase family Inhibitor_I9 PF05922.16 ELR24958.1 - 0.00015 22.4 0.0 0.00033 21.3 0.0 1.5 1 0 0 1 1 1 1 Peptidase inhibitor I9 zf-C3HC4_3 PF13920.6 ELR24959.1 - 0.0066 16.3 8.2 0.013 15.4 8.2 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) DUF4133 PF13571.6 ELR24959.1 - 0.071 13.5 0.2 0.12 12.7 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4133) COPI_assoc PF08507.10 ELR24961.1 - 4.7e-05 23.4 13.4 6.3e-05 23.0 13.4 1.1 1 0 0 1 1 1 1 COPI associated protein zf-CCCH_4 PF18044.1 ELR24962.1 - 4.2e-05 23.2 1.2 6.5e-05 22.6 1.2 1.3 1 0 0 1 1 1 1 CCCH-type zinc finger zf_CCCH_4 PF18345.1 ELR24962.1 - 6.5e-05 22.8 6.7 0.0001 22.2 6.7 1.3 1 0 0 1 1 1 1 Zinc finger domain Torus PF16131.5 ELR24962.1 - 0.00092 19.9 0.6 0.00092 19.9 0.6 1.5 2 0 0 2 2 2 1 Torus domain zf-CCCH PF00642.24 ELR24962.1 - 0.016 15.1 1.7 0.027 14.4 1.7 1.3 1 0 0 1 1 1 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_3 PF15663.5 ELR24962.1 - 0.023 14.9 0.4 0.041 14.1 0.4 1.3 1 0 0 1 1 1 0 Zinc-finger containing family Nucleoporin_FG PF13634.6 ELR24962.1 - 0.029 15.2 27.9 0.029 15.2 27.9 4.9 2 1 3 5 5 5 0 Nucleoporin FG repeat region PAP2 PF01569.21 ELR24963.1 - 2.4e-14 53.2 6.6 2.4e-14 53.2 6.6 1.8 2 1 0 2 2 2 1 PAP2 superfamily DUF212 PF02681.14 ELR24963.1 - 0.00013 22.1 1.4 0.018 15.2 0.0 2.4 1 1 1 2 2 2 2 Divergent PAP2 family DUF4040 PF13244.6 ELR24963.1 - 0.19 11.9 10.2 0.067 13.3 3.4 2.7 2 1 0 2 2 2 0 Domain of unknown function (DUF4040) DUF4191 PF13829.6 ELR24963.1 - 1.9 7.8 3.9 3.7 6.8 3.9 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4191) UbiA PF01040.18 ELR24963.1 - 2.6 7.3 12.1 5.6 6.2 12.1 1.6 1 1 0 1 1 1 0 UbiA prenyltransferase family DcpS_C PF11969.8 ELR24964.1 - 3.1e-14 53.4 0.7 7.2e-14 52.2 0.7 1.6 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding UBA PF00627.31 ELR24964.1 - 6.4e-13 48.3 4.0 1.1e-06 28.4 0.1 3.0 3 0 0 3 3 3 2 UBA/TS-N domain PARP PF00644.20 ELR24964.1 - 6.8e-12 45.4 4.3 2e-10 40.6 0.0 3.7 3 1 1 4 4 4 1 Poly(ADP-ribose) polymerase catalytic domain HIT PF01230.23 ELR24964.1 - 1.5e-06 28.9 0.3 5.3e-06 27.1 0.3 2.0 1 0 0 1 1 1 1 HIT domain CUE PF02845.16 ELR24964.1 - 0.00058 19.5 0.0 0.49 10.2 0.0 2.8 2 0 0 2 2 2 2 CUE domain Rtf2 PF04641.12 ELR24964.1 - 0.17 11.2 11.2 0.71 9.2 11.2 2.1 1 0 0 1 1 1 0 Rtf2 RING-finger DDHD PF02862.17 ELR24964.1 - 0.41 10.8 1.9 1.9 8.6 0.3 2.6 3 0 0 3 3 3 0 DDHD domain PH PF00169.29 ELR24965.1 - 4.6e-11 43.2 0.1 6.2e-11 42.7 0.1 1.3 1 0 0 1 1 1 1 PH domain PH_8 PF15409.6 ELR24965.1 - 6.3e-06 26.4 0.7 1.8e-05 24.9 0.4 1.9 2 0 0 2 2 2 1 Pleckstrin homology domain PH_11 PF15413.6 ELR24965.1 - 7.2e-06 26.4 0.8 1.3e-05 25.6 0.8 1.4 1 0 0 1 1 1 1 Pleckstrin homology domain NIF PF03031.18 ELR24966.1 - 5.3e-10 39.3 0.0 6.2e-10 39.1 0.0 1.1 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase DUF3446 PF11928.8 ELR24967.1 - 8.1 6.8 14.5 2.5 8.5 3.0 3.0 2 0 0 2 2 2 0 Early growth response N-terminal domain MoCF_biosynth PF00994.24 ELR24968.1 - 1e-32 112.8 0.2 1.2e-32 112.6 0.2 1.0 1 0 0 1 1 1 1 Probable molybdopterin binding domain DUF4314 PF14192.6 ELR24968.1 - 0.047 13.6 0.0 0.083 12.8 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4314) Nit_Regul_Hom PF10126.9 ELR24968.1 - 0.1 12.6 0.3 0.65 10.0 0.2 2.0 1 1 1 2 2 2 0 Uncharacterized protein, homolog of nitrogen regulatory protein PII UPF0220 PF05255.11 ELR24969.1 - 8.8e-26 90.4 3.5 1.2e-25 90.0 3.5 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0220) DMT_YdcZ PF04657.13 ELR24969.1 - 0.0075 16.6 1.4 0.0075 16.6 1.4 2.0 1 1 1 2 2 2 1 Putative inner membrane exporter, YdcZ adh_short_C2 PF13561.6 ELR24970.1 - 2.7e-54 184.2 0.0 3.7e-54 183.7 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 ELR24970.1 - 5.7e-45 153.2 0.0 6.8e-45 152.9 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 ELR24970.1 - 2.5e-07 30.8 0.0 3.7e-07 30.2 0.0 1.2 1 0 0 1 1 1 1 KR domain NusB PF01029.18 ELR24970.1 - 0.091 13.0 0.0 0.13 12.5 0.0 1.2 1 0 0 1 1 1 0 NusB family Amidohydro_1 PF01979.20 ELR24971.1 - 8.2e-18 64.8 0.0 1.1e-13 51.3 0.0 2.4 2 0 0 2 2 2 2 Amidohydrolase family Amidohydro_3 PF07969.11 ELR24971.1 - 1.4e-13 51.1 0.2 2.5e-06 27.3 0.0 2.4 2 0 0 2 2 2 2 Amidohydrolase family PD40 PF07676.12 ELR24971.1 - 1.9e-05 24.4 12.2 0.21 11.6 0.0 6.9 7 0 0 7 7 7 3 WD40-like Beta Propeller Repeat TAN PF11640.8 ELR24973.1 - 0.059 13.5 0.1 0.097 12.8 0.1 1.4 1 1 0 1 1 1 0 Telomere-length maintenance and DNA damage repair F-box-like PF12937.7 ELR24973.1 - 0.12 12.3 0.4 0.32 10.9 0.4 1.7 1 0 0 1 1 1 0 F-box-like PI3_PI4_kinase PF00454.27 ELR24974.1 - 3e-30 105.9 0.1 5.7e-28 98.4 0.1 2.3 1 1 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase PI3Ka PF00613.20 ELR24974.1 - 8.2e-07 28.6 0.1 2e-06 27.3 0.1 1.6 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) MEDS PF14417.6 ELR24974.1 - 0.14 12.0 0.0 0.31 10.9 0.0 1.5 1 0 0 1 1 1 0 MEDS: MEthanogen/methylotroph, DcmR Sensory domain Na_trans_assoc PF06512.13 ELR24974.1 - 1.9 8.7 20.1 1.2 9.3 12.1 2.4 2 0 0 2 2 2 0 Sodium ion transport-associated LRR_8 PF13855.6 ELR24975.1 - 8.8e-17 60.6 14.6 1.5e-06 27.8 0.1 3.4 3 0 0 3 3 3 3 Leucine rich repeat LRR_4 PF12799.7 ELR24975.1 - 6.1e-15 55.1 8.3 0.00011 22.4 0.1 3.6 3 0 0 3 3 3 3 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 ELR24975.1 - 0.0045 17.3 11.8 3.3 8.6 0.1 5.4 5 0 0 5 5 5 2 Leucine Rich Repeat LRR_6 PF13516.6 ELR24975.1 - 0.48 10.6 13.8 7.6 6.9 0.1 5.9 7 0 0 7 7 7 0 Leucine Rich repeat WD40 PF00400.32 ELR24976.1 - 4.7e-08 33.6 26.8 3.1e-05 24.7 0.1 5.8 6 0 0 6 6 6 2 WD domain, G-beta repeat PQQ_3 PF13570.6 ELR24976.1 - 0.00078 19.9 4.9 0.85 10.2 0.1 5.1 4 1 1 5 5 5 1 PQQ-like domain DUF5074 PF16819.5 ELR24976.1 - 0.14 12.3 1.6 0.91 9.6 0.0 2.8 3 1 0 3 3 3 0 Domain of unknown function (DUF5074) Reg_prop PF07494.11 ELR24976.1 - 3.9 8.0 12.6 25 5.5 0.1 5.9 6 1 1 7 7 7 0 Two component regulator propeller PGM_PMM_I PF02878.16 ELR24977.1 - 8.9e-36 122.6 0.0 9.7e-36 122.5 0.0 1.0 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I Telomere_reg-2 PF10193.9 ELR24979.1 - 4.1e-29 101.2 0.0 1.1e-28 99.8 0.0 1.8 1 0 0 1 1 1 1 Telomere length regulation protein RNase_T PF00929.24 ELR24980.1 - 1.9e-21 77.3 0.1 1.9e-21 77.3 0.1 1.6 2 0 0 2 2 2 1 Exonuclease zf-RanBP PF00641.18 ELR24980.1 - 4.1e-16 58.0 30.2 4.9e-05 22.6 2.1 4.4 4 0 0 4 4 4 4 Zn-finger in Ran binding protein and others RRM_1 PF00076.22 ELR24980.1 - 4.8e-09 35.9 0.0 8.6e-09 35.1 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DZR PF12773.7 ELR24980.1 - 1.9e-05 24.6 21.2 0.05 13.6 6.7 3.6 3 1 0 3 3 3 3 Double zinc ribbon HemX PF04375.14 ELR24980.1 - 0.00084 18.7 7.8 0.0012 18.2 7.8 1.1 1 0 0 1 1 1 1 HemX, putative uroporphyrinogen-III C-methyltransferase Acetyltransf_3 PF13302.7 ELR24980.1 - 0.0013 19.4 0.6 2.7 8.7 0.0 3.8 3 1 1 4 4 4 1 Acetyltransferase (GNAT) domain TackOD1 PF18551.1 ELR24980.1 - 0.15 11.7 26.4 1.6 8.3 0.4 4.3 3 1 0 4 4 4 0 Thaumarchaeal output domain 1 Ribosomal_L40e PF01020.17 ELR24980.1 - 0.49 10.3 8.5 41 4.2 0.3 4.4 4 0 0 4 4 4 0 Ribosomal L40e family Rpp20 PF12328.8 ELR24981.1 - 7e-11 42.2 0.0 5.2e-06 26.5 0.0 2.5 1 1 1 2 2 2 2 Rpp20 subunit of nuclear RNase MRP and P Alba PF01918.21 ELR24981.1 - 6.8e-10 38.6 0.0 8.6e-10 38.3 0.0 1.2 1 0 0 1 1 1 1 Alba TCTP PF00838.17 ELR24982.1 - 1.9e-52 178.0 0.2 2.2e-52 177.8 0.2 1.0 1 0 0 1 1 1 1 Translationally controlled tumour protein WD40 PF00400.32 ELR24983.1 - 1.5e-39 133.2 27.9 1.7e-07 31.8 0.8 7.4 7 0 0 7 7 7 7 WD domain, G-beta repeat F-box-like PF12937.7 ELR24983.1 - 1e-10 41.3 0.8 1e-10 41.3 0.8 2.0 2 0 0 2 2 2 1 F-box-like ANAPC4_WD40 PF12894.7 ELR24983.1 - 1e-05 25.7 1.9 0.036 14.4 0.1 4.1 2 2 3 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain F-box PF00646.33 ELR24983.1 - 0.00026 20.8 0.7 0.00061 19.6 0.7 1.6 1 0 0 1 1 1 1 F-box domain BBS2_Mid PF14783.6 ELR24983.1 - 0.00043 20.3 0.3 0.037 14.1 0.1 3.1 2 2 0 2 2 2 1 Ciliary BBSome complex subunit 2, middle region WD40_like PF17005.5 ELR24983.1 - 0.0045 16.4 0.1 0.061 12.7 0.1 2.3 1 1 0 1 1 1 1 WD40-like domain Nup160 PF11715.8 ELR24983.1 - 0.15 10.7 9.8 1 7.9 0.1 4.3 2 2 2 4 4 4 0 Nucleoporin Nup120/160 AAA_5 PF07728.14 ELR24984.1 - 2.8e-67 224.9 2.5 1e-26 93.6 0.0 5.1 4 1 0 4 4 3 3 AAA domain (dynein-related subfamily) VWA PF00092.28 ELR24984.1 - 1.7e-05 25.1 0.0 4.1e-05 23.9 0.0 1.6 1 0 0 1 1 1 1 von Willebrand factor type A domain AAA_22 PF13401.6 ELR24984.1 - 2.7e-05 24.4 0.2 0.0004 20.7 0.0 2.7 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 ELR24984.1 - 0.00012 22.5 2.2 0.0065 16.9 0.0 4.4 5 0 0 5 5 5 1 AAA ATPase domain VWA_2 PF13519.6 ELR24984.1 - 0.00019 22.0 0.0 0.0007 20.2 0.0 2.0 1 0 0 1 1 1 1 von Willebrand factor type A domain AAA_24 PF13479.6 ELR24984.1 - 0.0057 16.4 0.0 0.053 13.2 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_6 PF12774.7 ELR24984.1 - 0.011 14.8 0.0 0.02 13.9 0.0 1.4 1 0 0 1 1 1 0 Hydrolytic ATP binding site of dynein motor region AAA_33 PF13671.6 ELR24984.1 - 0.013 15.7 0.0 0.039 14.1 0.0 1.9 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 ELR24984.1 - 0.016 14.8 0.0 0.035 13.6 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA PF00004.29 ELR24984.1 - 0.024 15.1 0.0 0.21 12.0 0.0 2.7 2 0 0 2 2 1 0 ATPase family associated with various cellular activities (AAA) TsaE PF02367.17 ELR24984.1 - 0.028 14.4 0.0 0.086 12.8 0.0 1.8 2 0 0 2 2 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE NACHT PF05729.12 ELR24984.1 - 0.029 14.3 0.0 0.11 12.5 0.0 2.0 1 0 0 1 1 1 0 NACHT domain DnaB_C PF03796.15 ELR24984.1 - 0.067 12.5 0.0 0.15 11.4 0.0 1.5 1 0 0 1 1 1 0 DnaB-like helicase C terminal domain ACBP PF00887.19 ELR24984.1 - 0.079 13.2 0.9 0.26 11.5 0.9 1.8 1 0 0 1 1 1 0 Acyl CoA binding protein DUF1676 PF07898.13 ELR24984.1 - 0.12 12.4 0.3 0.34 10.9 0.3 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1676) ATPase_2 PF01637.18 ELR24984.1 - 0.22 11.4 0.5 0.49 10.3 0.0 1.8 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea vATP-synt_E PF01991.18 ELR24984.1 - 0.25 10.7 3.9 0.57 9.6 3.9 1.6 1 0 0 1 1 1 0 ATP synthase (E/31 kDa) subunit DUF815 PF05673.13 ELR24984.1 - 0.36 10.0 1.7 1.3 8.2 0.0 2.6 4 0 0 4 4 4 0 Protein of unknown function (DUF815) HMG_box PF00505.19 ELR24986.1 - 2.5e-32 111.1 21.0 3.4e-15 56.2 0.2 4.0 4 0 0 4 4 4 3 HMG (high mobility group) box HMG_box_2 PF09011.10 ELR24986.1 - 1.5e-22 80.0 22.5 5.9e-11 42.8 0.2 4.5 3 1 1 4 4 4 3 HMG-box domain YABBY PF04690.13 ELR24986.1 - 0.0001 22.9 0.0 0.0001 22.9 0.0 3.7 2 1 1 3 3 3 1 YABBY protein CHDNT PF08073.12 ELR24986.1 - 0.093 12.7 0.0 0.23 11.4 0.0 1.6 1 0 0 1 1 1 0 CHDNT (NUC034) domain PPP4R2 PF09184.11 ELR24986.1 - 4.5 6.8 41.5 0.028 14.0 30.6 2.6 3 0 0 3 3 3 0 PPP4R2 Thioredoxin PF00085.20 ELR24987.1 - 6.5e-13 48.6 0.2 4.5e-12 45.9 0.2 2.1 1 1 0 1 1 1 1 Thioredoxin FAM176 PF14851.6 ELR24987.1 - 0.0046 16.6 1.1 0.0075 15.9 1.1 1.3 1 0 0 1 1 1 1 FAM176 family DUF4834 PF16118.5 ELR24987.1 - 0.0063 17.5 0.9 0.01 16.7 0.9 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4834) OST3_OST6 PF04756.13 ELR24987.1 - 0.0098 15.3 0.1 0.0098 15.3 0.1 2.1 1 1 2 3 3 3 1 OST3 / OST6 family, transporter family tRNA_anti-like PF12869.7 ELR24987.1 - 0.01 15.5 1.4 0.13 11.9 0.1 2.6 2 1 1 3 3 3 0 tRNA_anti-like CobT PF06213.12 ELR24987.1 - 0.013 14.9 8.7 0.018 14.4 8.7 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT TRAP_alpha PF03896.16 ELR24987.1 - 0.015 14.5 0.7 0.019 14.2 0.7 1.1 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Presenilin PF01080.17 ELR24987.1 - 0.022 13.6 0.7 0.026 13.3 0.7 1.2 1 0 0 1 1 1 0 Presenilin WBP-1 PF11669.8 ELR24987.1 - 0.025 15.2 1.1 0.067 13.8 1.1 1.8 1 1 0 1 1 1 0 WW domain-binding protein 1 Connexin PF00029.19 ELR24987.1 - 0.028 14.2 0.6 0.034 13.9 0.6 1.2 1 0 0 1 1 1 0 Connexin CCDC53 PF10152.9 ELR24987.1 - 0.033 14.6 6.1 0.055 13.9 6.1 1.2 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex V_ATPase_I PF01496.19 ELR24987.1 - 0.038 11.9 2.6 0.05 11.5 2.6 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Serinc PF03348.15 ELR24987.1 - 0.044 12.7 0.7 0.055 12.4 0.7 1.2 1 0 0 1 1 1 0 Serine incorporator (Serinc) CPSF100_C PF13299.6 ELR24987.1 - 0.044 14.0 2.8 0.062 13.5 2.8 1.2 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal SpoIIP PF07454.11 ELR24987.1 - 0.051 13.0 3.2 0.062 12.7 3.2 1.2 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) G0-G1_switch_2 PF15103.6 ELR24987.1 - 0.054 13.9 2.1 0.094 13.2 2.1 1.3 1 0 0 1 1 1 0 G0/G1 switch protein 2 TRM13 PF05206.14 ELR24987.1 - 0.062 12.8 0.3 0.088 12.3 0.3 1.3 1 0 0 1 1 1 0 Methyltransferase TRM13 DUF4820 PF16091.5 ELR24987.1 - 0.069 12.5 1.6 0.094 12.1 1.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) CLN3 PF02487.17 ELR24987.1 - 0.075 12.1 1.0 0.1 11.6 1.0 1.1 1 0 0 1 1 1 0 CLN3 protein FAM209 PF15206.6 ELR24987.1 - 0.088 12.6 0.0 0.16 11.8 0.0 1.4 1 0 0 1 1 1 0 FAM209 family Conotoxin PF02950.17 ELR24987.1 - 0.11 13.5 3.9 0.12 13.4 1.5 2.3 2 1 0 2 2 2 0 Conotoxin OATP PF03137.20 ELR24987.1 - 0.11 10.8 0.2 0.12 10.6 0.2 1.1 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family Mucin PF01456.17 ELR24987.1 - 0.11 12.5 0.0 0.18 11.8 0.0 1.5 1 0 0 1 1 1 0 Mucin-like glycoprotein DUF2722 PF10846.8 ELR24987.1 - 0.14 11.0 9.5 0.17 10.8 9.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Neur_chan_memb PF02932.16 ELR24987.1 - 0.17 11.9 2.0 0.27 11.3 2.0 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region EphA2_TM PF14575.6 ELR24987.1 - 0.21 12.5 1.1 0.75 10.7 1.1 1.9 1 1 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain DUF4175 PF13779.6 ELR24987.1 - 0.56 8.1 13.1 0.74 7.6 13.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) SPG4 PF17325.2 ELR24987.1 - 0.76 10.9 7.0 1.2 10.3 7.0 1.3 1 0 0 1 1 1 0 Stationary phase protein 4 RR_TM4-6 PF06459.12 ELR24987.1 - 0.77 9.5 9.0 1.1 9.1 9.0 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 TERB2 PF15101.6 ELR24987.1 - 0.99 9.4 7.5 1.4 8.9 7.5 1.2 1 0 0 1 1 1 0 Telomere-associated protein TERB2 DDRGK PF09756.9 ELR24987.1 - 1.1 8.8 13.3 1.5 8.4 13.3 1.2 1 0 0 1 1 1 0 DDRGK domain DUF4770 PF15994.5 ELR24987.1 - 1.6 9.0 8.3 2.1 8.5 8.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) Peptidase_S49_N PF08496.10 ELR24987.1 - 1.9 8.6 7.2 2.1 8.4 5.8 1.7 1 1 1 2 2 2 0 Peptidase family S49 N-terminal DUF3306 PF11748.8 ELR24987.1 - 2.1 9.2 9.7 3.4 8.6 9.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3306) TMEM51 PF15345.6 ELR24987.1 - 4.3 7.1 8.3 6.3 6.6 8.0 1.4 1 1 0 1 1 1 0 Transmembrane protein 51 EMC3_TMCO1 PF01956.16 ELR24988.1 - 5.6e-30 104.3 0.1 7.9e-30 103.8 0.1 1.1 1 0 0 1 1 1 1 Integral membrane protein EMC3/TMCO1-like Tho2 PF11262.8 ELR24988.1 - 0.078 12.2 0.9 0.11 11.7 0.9 1.1 1 0 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 Folate_carrier PF01770.18 ELR24988.1 - 0.36 9.5 3.1 0.11 11.2 0.3 1.5 2 0 0 2 2 2 0 Reduced folate carrier LRR_8 PF13855.6 ELR24990.1 - 1e-14 54.0 14.7 5.5e-07 29.3 2.2 4.2 3 2 1 4 4 4 3 Leucine rich repeat FYVE PF01363.21 ELR24990.1 - 4.8e-13 49.0 15.9 3.7e-12 46.2 15.9 2.2 1 1 0 1 1 1 1 FYVE zinc finger LRR_4 PF12799.7 ELR24990.1 - 1.1e-11 44.7 14.5 0.0001 22.6 1.9 5.3 1 1 7 8 8 8 6 Leucine Rich repeats (2 copies) SH3_9 PF14604.6 ELR24990.1 - 9.7e-09 35.0 0.0 1.8e-08 34.1 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain LRR_9 PF14580.6 ELR24990.1 - 3.2e-07 30.0 2.2 0.0031 17.1 0.1 2.3 1 1 0 2 2 2 2 Leucine-rich repeat SH3_2 PF07653.17 ELR24990.1 - 2e-05 24.2 0.0 3.1e-05 23.5 0.0 1.3 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 ELR24990.1 - 2.8e-05 23.6 0.0 5.5e-05 22.7 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SH3_3 PF08239.11 ELR24990.1 - 0.0057 16.9 0.1 0.011 16.0 0.1 1.4 1 0 0 1 1 1 1 Bacterial SH3 domain LRR_1 PF00560.33 ELR24990.1 - 0.033 14.7 5.6 15 6.6 0.1 5.3 5 1 0 5 5 5 0 Leucine Rich Repeat GASA PF02704.14 ELR24990.1 - 1.1 9.5 10.4 2.3 8.4 10.4 1.5 1 0 0 1 1 1 0 Gibberellin regulated protein Ndc1_Nup PF09531.10 ELR24990.1 - 2.3 6.8 11.0 3.4 6.3 11.0 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup LRR_6 PF13516.6 ELR24990.1 - 5.3 7.4 9.4 1.3e+02 3.0 0.0 5.3 6 0 0 6 6 6 0 Leucine Rich repeat CH PF00307.31 ELR24991.1 - 3e-19 69.2 0.1 6.5e-19 68.1 0.1 1.5 1 0 0 1 1 1 1 Calponin homology (CH) domain FAD_syn PF06574.12 ELR24991.1 - 7.8e-09 35.6 8.2 0.035 14.0 0.1 5.2 2 2 3 5 5 5 2 FAD synthetase CDC24 PF06395.11 ELR24991.1 - 0.0012 19.0 0.1 0.0038 17.4 0.1 1.9 1 0 0 1 1 1 1 CDC24 Calponin CAMSAP_CH PF11971.8 ELR24991.1 - 0.0021 17.9 0.0 0.004 16.9 0.0 1.4 1 0 0 1 1 1 1 CAMSAP CH domain Virulence_fact PF13769.6 ELR24991.1 - 0.0039 17.4 11.3 12 6.2 0.3 5.4 2 1 3 6 6 6 1 Virulence factor dDENN PF03455.19 ELR24991.1 - 0.01 15.8 1.1 1e+02 3.0 0.0 5.0 5 0 0 5 5 5 0 dDENN domain Spore_GerQ PF09671.10 ELR24991.1 - 0.021 14.8 1.6 10 6.2 0.1 3.9 1 1 1 4 4 4 0 Spore coat protein (Spore_GerQ) Rhamnogal_lyase PF06045.11 ELR24991.1 - 0.095 12.1 0.4 11 5.3 0.0 2.7 1 1 2 3 3 3 0 Rhamnogalacturonate lyase family Pollen_allerg_2 PF01620.16 ELR24991.1 - 0.17 12.1 1.6 0.23 11.6 0.0 2.0 2 1 0 2 2 2 0 Ribonuclease (pollen allergen) ATP-grasp_6 PF18419.1 ELR24991.1 - 0.23 11.1 8.0 22 4.8 0.1 5.5 6 2 0 6 6 6 0 ATP-grasp-like domain DUF3741 PF12552.8 ELR24991.1 - 0.76 9.8 10.0 95 3.1 0.0 5.9 7 0 0 7 7 7 0 Protein of unknown function (DUF3741) Class_IIIsignal PF04021.12 ELR24991.1 - 1.1 9.4 2.9 46 4.2 0.1 4.0 5 0 0 5 5 5 0 Class III signal peptide SAB PF04382.13 ELR24991.1 - 5.6 7.1 9.6 70 3.6 0.1 5.1 6 0 0 6 6 6 0 SAB domain RusA PF05866.11 ELR24991.1 - 6.3 7.4 6.7 52 4.4 0.1 4.2 3 1 0 4 4 4 0 Endodeoxyribonuclease RusA RFC1 PF08519.12 ELR24992.1 - 6.8e-52 175.8 0.0 1.7e-51 174.5 0.0 1.7 1 0 0 1 1 1 1 Replication factor RFC1 C terminal domain AAA PF00004.29 ELR24992.1 - 1.2e-12 48.4 0.1 3.7e-12 46.8 0.0 1.9 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) BRCT PF00533.26 ELR24992.1 - 1.5e-08 34.9 0.0 5e-08 33.2 0.0 1.9 2 0 0 2 2 2 1 BRCA1 C Terminus (BRCT) domain Rad17 PF03215.15 ELR24992.1 - 2e-07 31.1 0.1 4.6e-07 29.9 0.1 1.5 1 0 0 1 1 1 1 Rad17 P-loop domain AAA_assoc_2 PF16193.5 ELR24992.1 - 8.1e-05 22.9 0.1 0.00026 21.3 0.1 1.9 1 0 0 1 1 1 1 AAA C-terminal domain PTCB-BRCT PF12738.7 ELR24992.1 - 0.00055 19.8 0.1 0.0014 18.5 0.1 1.7 1 0 0 1 1 1 1 twin BRCT domain RuvB_N PF05496.12 ELR24992.1 - 0.00058 19.6 0.0 0.0017 18.2 0.0 1.7 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_33 PF13671.6 ELR24992.1 - 0.001 19.2 0.1 0.006 16.8 0.0 2.4 2 1 0 2 2 2 1 AAA domain DNA_pol3_delta PF06144.13 ELR24992.1 - 0.001 18.9 0.0 0.0021 17.9 0.0 1.5 1 0 0 1 1 1 1 DNA polymerase III, delta subunit AAA_22 PF13401.6 ELR24992.1 - 0.0011 19.3 0.2 0.024 14.9 0.2 3.0 1 1 1 2 2 2 1 AAA domain AAA_16 PF13191.6 ELR24992.1 - 0.0011 19.4 0.0 0.011 16.2 0.1 2.5 1 1 1 2 2 2 1 AAA ATPase domain AAA_14 PF13173.6 ELR24992.1 - 0.011 15.7 0.0 0.024 14.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 ELR24992.1 - 0.025 14.1 0.0 0.044 13.3 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region RNA_helicase PF00910.22 ELR24992.1 - 0.031 14.7 0.1 0.15 12.4 0.0 2.2 2 1 0 2 2 2 0 RNA helicase AAA_18 PF13238.6 ELR24992.1 - 0.035 14.6 0.0 0.11 13.0 0.0 1.8 1 0 0 1 1 1 0 AAA domain Sigma54_activ_2 PF14532.6 ELR24992.1 - 0.056 13.6 0.0 0.16 12.1 0.0 1.7 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_5 PF07728.14 ELR24992.1 - 0.07 13.1 0.0 0.19 11.7 0.0 1.8 2 0 0 2 2 1 0 AAA domain (dynein-related subfamily) NTPase_1 PF03266.15 ELR24992.1 - 0.12 12.3 0.1 0.44 10.4 0.0 2.0 1 1 1 2 2 2 0 NTPase DUF773 PF05600.12 ELR24992.1 - 0.3 9.8 2.9 0.5 9.0 2.9 1.3 1 0 0 1 1 1 0 CDK5 regulatory subunit-associated protein 3 AAA_11 PF13086.6 ELR24992.1 - 0.44 10.3 6.5 0.48 10.2 0.0 2.5 2 0 0 2 2 2 0 AAA domain DIRP PF06584.13 ELR24993.1 - 7.6e-25 87.1 0.0 1.6e-24 86.1 0.0 1.6 1 0 0 1 1 1 1 DIRP Myb_DNA-binding PF00249.31 ELR24993.1 - 1.1e-07 31.9 0.1 2.6e-07 30.7 0.1 1.5 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 ELR24993.1 - 0.00028 21.1 0.0 0.00069 19.8 0.0 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_7 PF15963.5 ELR24993.1 - 0.0011 18.8 1.2 0.0023 17.8 0.0 2.1 2 0 0 2 2 2 1 Myb DNA-binding like TRAUB PF08164.12 ELR24993.1 - 0.017 15.6 0.7 0.049 14.1 0.7 1.7 1 0 0 1 1 1 0 Apoptosis-antagonizing transcription factor, C-terminal Ras PF00071.22 ELR24994.1 - 9.9e-47 158.6 0.3 1.2e-46 158.3 0.3 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR24994.1 - 1.5e-29 102.7 0.3 2.2e-29 102.1 0.3 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR24994.1 - 9.4e-12 44.7 0.1 1.2e-11 44.4 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 ELR24994.1 - 2e-09 37.1 0.0 2.4e-09 36.9 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region AAA_7 PF12775.7 ELR24994.1 - 5.3e-05 22.8 0.0 0.00011 21.8 0.0 1.4 1 0 0 1 1 1 1 P-loop containing dynein motor region MMR_HSR1 PF01926.23 ELR24994.1 - 8.5e-05 22.6 0.1 0.00013 22.1 0.1 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 ELR24994.1 - 0.00041 20.0 0.2 0.0045 16.6 0.0 2.1 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain PduV-EutP PF10662.9 ELR24994.1 - 0.00085 19.1 0.0 0.69 9.7 0.0 2.4 2 1 0 2 2 2 2 Ethanolamine utilisation - propanediol utilisation SRPRB PF09439.10 ELR24994.1 - 0.001 18.6 0.0 0.0012 18.3 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit ATP_bind_1 PF03029.17 ELR24994.1 - 0.0045 16.8 0.3 0.15 11.8 0.0 2.1 1 1 1 2 2 2 1 Conserved hypothetical ATP binding protein RsgA_GTPase PF03193.16 ELR24994.1 - 0.0048 16.8 0.0 0.18 11.7 0.0 2.2 2 0 0 2 2 2 1 RsgA GTPase cobW PF02492.19 ELR24994.1 - 0.012 15.2 0.0 0.88 9.1 0.0 2.3 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain TniB PF05621.11 ELR24994.1 - 0.018 14.4 0.0 0.042 13.3 0.0 1.5 1 1 0 1 1 1 0 Bacterial TniB protein TsaE PF02367.17 ELR24994.1 - 0.027 14.5 0.0 0.06 13.3 0.0 1.4 1 1 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA PF00004.29 ELR24994.1 - 0.029 14.8 0.0 0.071 13.5 0.0 1.7 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 ELR24994.1 - 0.035 14.4 0.0 0.05 13.9 0.0 1.4 1 1 0 1 1 1 0 AAA domain AAA_16 PF13191.6 ELR24994.1 - 0.036 14.4 0.0 0.05 14.0 0.0 1.7 1 1 0 1 1 1 0 AAA ATPase domain DLIC PF05783.11 ELR24994.1 - 0.055 12.3 2.7 0.82 8.4 0.4 2.7 1 1 2 3 3 3 0 Dynein light intermediate chain (DLIC) MMR_HSR1_Xtn PF16897.5 ELR24994.1 - 0.058 13.4 0.1 0.099 12.7 0.1 1.4 1 0 0 1 1 1 0 C-terminal region of MMR_HSR1 domain DUF815 PF05673.13 ELR24994.1 - 0.11 11.6 0.0 0.21 10.7 0.0 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF815) ATPase_2 PF01637.18 ELR24994.1 - 0.14 12.1 0.2 0.33 10.8 0.2 1.8 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_32 PF13654.6 ELR24994.1 - 0.2 10.4 0.1 0.37 9.5 0.1 1.3 1 0 0 1 1 1 0 AAA domain UPF0259 PF06790.11 ELR24995.1 - 0.048 13.4 0.1 0.068 12.9 0.1 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0259) WD40 PF00400.32 ELR24996.1 - 9.2e-20 70.6 13.0 3e-05 24.7 0.1 6.5 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ELR24996.1 - 1.1e-08 35.3 0.0 0.33 11.3 0.0 4.8 3 2 2 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain LisH_TPL PF17814.1 ELR24996.1 - 0.0014 18.3 0.2 0.0032 17.1 0.2 1.6 1 0 0 1 1 1 1 LisH-like dimerisation domain Frtz PF11768.8 ELR24996.1 - 0.015 13.6 0.0 0.25 9.6 0.0 2.4 1 1 1 2 2 2 0 WD repeat-containing and planar cell polarity effector protein Fritz Pyr_redox_2 PF07992.14 ELR24996.1 - 0.029 13.6 0.0 0.078 12.2 0.0 1.6 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase eIF2A PF08662.11 ELR24996.1 - 0.043 13.7 0.0 0.12 12.2 0.0 1.7 2 0 0 2 2 2 0 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 ELR24996.1 - 0.25 10.6 0.0 0.42 9.9 0.0 1.5 1 0 0 1 1 1 0 WD40-like domain AAA PF00004.29 ELR24997.1 - 5.1e-10 39.9 0.0 1e-09 38.9 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Cdc6_C PF09079.11 ELR24997.1 - 7.9e-09 35.4 0.0 3e-08 33.5 0.0 2.0 2 0 0 2 2 2 1 CDC6, C terminal winged helix domain AAA_22 PF13401.6 ELR24997.1 - 1.6e-08 34.9 0.0 3.7e-08 33.7 0.0 1.6 1 0 0 1 1 1 1 AAA domain NACHT PF05729.12 ELR24997.1 - 6.5e-05 22.9 0.0 0.00015 21.7 0.0 1.6 1 0 0 1 1 1 1 NACHT domain AAA_16 PF13191.6 ELR24997.1 - 0.00014 22.3 0.8 0.00014 22.3 0.8 3.3 3 2 0 3 3 2 1 AAA ATPase domain DUF2075 PF09848.9 ELR24997.1 - 0.00045 19.6 0.0 0.00086 18.6 0.0 1.4 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) AAA_19 PF13245.6 ELR24997.1 - 0.001 19.4 0.1 0.0036 17.7 0.1 1.9 1 1 0 1 1 1 1 AAA domain AAA_lid_10 PF17872.1 ELR24997.1 - 0.0079 16.3 0.2 0.022 14.8 0.0 1.8 2 0 0 2 2 2 1 AAA lid domain TniB PF05621.11 ELR24997.1 - 0.0099 15.3 0.0 0.026 13.9 0.0 1.6 1 0 0 1 1 1 1 Bacterial TniB protein DEAD PF00270.29 ELR24997.1 - 0.021 14.6 0.1 0.54 10.0 0.0 2.3 1 1 1 2 2 2 0 DEAD/DEAH box helicase PIF1 PF05970.14 ELR24997.1 - 0.029 13.5 0.0 0.044 12.9 0.0 1.2 1 0 0 1 1 1 0 PIF1-like helicase T2SSE PF00437.20 ELR24997.1 - 0.056 12.5 0.0 0.094 11.8 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein UvrD-helicase PF00580.21 ELR24997.1 - 0.059 12.9 0.0 0.11 12.0 0.0 1.4 1 0 0 1 1 1 0 UvrD/REP helicase N-terminal domain ATPase_2 PF01637.18 ELR24997.1 - 0.1 12.5 0.1 6.4 6.6 0.0 2.3 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea AA_kinase PF00696.28 ELR24998.1 - 1.2e-27 97.1 0.3 9.4e-13 48.3 0.0 2.5 2 0 0 2 2 2 2 Amino acid kinase family Aldedh PF00171.22 ELR24998.1 - 5.7e-15 54.8 2.9 1.4e-09 37.0 0.9 2.4 2 1 0 2 2 2 2 Aldehyde dehydrogenase family WD40 PF00400.32 ELR24999.1 - 2.1e-12 47.3 1.3 0.0017 19.1 0.0 5.4 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ELR24999.1 - 4.5e-07 30.1 0.1 0.0028 17.9 0.1 3.2 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Ank_5 PF13857.6 ELR25000.1 - 3.4e-16 59.1 3.9 8.4e-07 29.2 1.6 3.1 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 ELR25000.1 - 8.1e-12 45.6 1.0 2.2e-11 44.2 0.9 1.7 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ELR25000.1 - 8.2e-10 39.0 0.4 1.6e-07 31.7 0.3 2.7 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 ELR25000.1 - 3.4e-09 36.2 0.6 0.0033 17.8 0.3 3.5 4 0 0 4 4 4 2 Ankyrin repeat Ank PF00023.30 ELR25000.1 - 1.2e-08 35.0 4.1 0.014 15.8 1.6 3.5 4 0 0 4 4 4 3 Ankyrin repeat Peptidase_M16 PF00675.20 ELR25000.1 - 0.05 13.6 0.0 0.066 13.2 0.0 1.2 1 0 0 1 1 1 0 Insulinase (Peptidase family M16) Myb_DNA-binding PF00249.31 ELR25001.1 - 2.2e-07 30.9 0.1 4.2e-07 30.1 0.1 1.5 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 ELR25001.1 - 0.005 17.1 0.0 0.0098 16.1 0.0 1.5 1 0 0 1 1 1 1 Myb-like DNA-binding domain PPP4R2 PF09184.11 ELR25001.1 - 0.17 11.5 6.8 0.26 10.8 1.8 2.2 2 0 0 2 2 2 0 PPP4R2 DUF3439 PF11921.8 ELR25001.1 - 1.2 9.2 8.7 2 8.4 8.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) Dicty_REP PF05086.12 ELR25001.1 - 1.2 7.0 4.3 1.9 6.4 4.3 1.2 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein MSP1_C PF07462.11 ELR25001.1 - 1.4 7.5 2.8 2 7.0 2.8 1.2 1 0 0 1 1 1 0 Merozoite surface protein 1 (MSP1) C-terminus Glyco_transf_7C PF02709.14 ELR25002.1 - 1.8e-17 62.7 0.2 4e-17 61.6 0.2 1.6 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase Glyco_transf_7N PF13733.6 ELR25002.1 - 1.1e-07 31.5 0.1 1.8e-07 30.9 0.1 1.2 1 0 0 1 1 1 1 N-terminal region of glycosyl transferase group 7 Rad1 PF02144.16 ELR25002.1 - 0.0032 16.6 0.0 0.0042 16.2 0.0 1.1 1 0 0 1 1 1 1 Repair protein Rad1/Rec1/Rad17 OmpH PF03938.14 ELR25003.1 - 0.48 10.8 20.2 0.8 10.0 20.2 1.3 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) HIP1_clath_bdg PF16515.5 ELR25003.1 - 1.1 9.9 21.5 7 7.3 21.5 2.1 1 1 0 1 1 1 0 Clathrin-binding domain of Huntingtin-interacting protein 1 RR_TM4-6 PF06459.12 ELR25003.1 - 4.3 7.1 14.7 5.9 6.6 14.7 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 IF-2B PF01008.17 ELR25004.1 - 1.5e-81 273.7 0.5 2e-81 273.3 0.5 1.1 1 0 0 1 1 1 1 Initiation factor 2 subunit family Radical_SAM_C PF16199.5 ELR25005.1 - 5.1e-32 109.7 0.0 9.2e-32 108.9 0.0 1.4 1 0 0 1 1 1 1 Radical_SAM C-terminal domain Radical_SAM PF04055.21 ELR25005.1 - 2.7e-19 70.2 0.5 7.8e-19 68.7 0.1 1.9 3 0 0 3 3 3 1 Radical SAM superfamily Acetyltransf_1 PF00583.25 ELR25005.1 - 5.8e-10 39.4 0.0 1.8e-09 37.8 0.1 1.8 2 0 0 2 2 2 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 ELR25005.1 - 4.3e-06 26.7 0.0 9.1e-06 25.6 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 ELR25005.1 - 0.0024 18.3 0.0 0.0047 17.3 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain RVT_2 PF07727.14 ELR25006.1 - 0.0002 21.1 0.2 0.0003 20.5 0.2 1.3 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DEAD PF00270.29 ELR25007.1 - 1.2e-49 168.5 0.0 2.1e-49 167.7 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ELR25007.1 - 7.7e-34 116.4 0.0 1.6e-33 115.3 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 ELR25007.1 - 6.7e-06 26.2 0.0 1e-05 25.6 0.0 1.2 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit UTP25 PF06862.12 ELR25007.1 - 0.023 13.5 0.0 0.2 10.4 0.0 2.2 2 1 1 3 3 3 0 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 AAA_22 PF13401.6 ELR25007.1 - 0.044 14.1 0.1 0.95 9.7 0.0 2.3 2 0 0 2 2 2 0 AAA domain CMS1 PF14617.6 ELR25007.1 - 0.25 10.7 0.0 0.46 9.8 0.0 1.3 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit Pkinase PF00069.25 ELR25008.1 - 5.7e-68 229.1 0.0 1.3e-67 228.0 0.0 1.6 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR25008.1 - 6.9e-36 123.8 0.0 1e-35 123.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase EF-hand_7 PF13499.6 ELR25008.1 - 9.1e-12 45.3 6.4 1.4e-06 28.6 0.2 3.5 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 ELR25008.1 - 3.3e-11 41.9 10.1 0.00034 20.0 0.2 5.4 5 0 0 5 5 5 4 EF hand EF-hand_6 PF13405.6 ELR25008.1 - 3.5e-11 42.1 8.9 0.028 14.3 0.2 5.1 5 0 0 5 5 5 4 EF-hand domain EF-hand_5 PF13202.6 ELR25008.1 - 8e-10 37.8 9.3 0.0025 17.2 0.3 4.6 4 0 0 4 4 4 3 EF hand Kinase-like PF14531.6 ELR25008.1 - 0.00015 21.2 0.0 0.00043 19.7 0.0 1.7 2 1 0 2 2 2 1 Kinase-like APH PF01636.23 ELR25008.1 - 0.0032 17.4 1.0 0.021 14.8 0.2 2.4 2 1 1 3 3 3 1 Phosphotransferase enzyme family EF-hand_8 PF13833.6 ELR25008.1 - 0.014 15.3 8.4 4.8 7.1 0.0 4.5 4 0 0 4 4 4 0 EF-hand domain pair EF-hand_14 PF17959.1 ELR25008.1 - 0.017 15.4 2.2 0.14 12.5 0.0 3.1 3 1 1 4 4 4 0 EF-hand domain Choline_kinase PF01633.20 ELR25008.1 - 0.023 14.3 0.1 0.023 14.3 0.1 1.8 2 0 0 2 2 1 0 Choline/ethanolamine kinase EF-hand_4 PF12763.7 ELR25008.1 - 0.22 11.5 2.5 0.21 11.5 0.2 2.1 2 0 0 2 2 2 0 Cytoskeletal-regulatory complex EF hand FAD_binding_3 PF01494.19 ELR25009.1 - 4.8e-10 39.2 3.9 3.4e-09 36.4 3.9 1.9 1 1 0 1 1 1 1 FAD binding domain MOSC_N PF03476.16 ELR25011.1 - 3.4e-27 94.7 0.0 8.6e-20 70.8 0.0 2.3 1 1 1 2 2 2 2 MOSC N-terminal beta barrel domain MOSC PF03473.17 ELR25011.1 - 1.2e-20 73.8 0.0 2.6e-20 72.7 0.0 1.6 1 0 0 1 1 1 1 MOSC domain FtsK_gamma PF09397.10 ELR25012.1 - 5.7e-07 29.2 0.3 2.1e-05 24.2 0.0 2.3 2 0 0 2 2 2 1 Ftsk gamma domain eIF-3c_N PF05470.12 ELR25012.1 - 0.71 8.1 10.0 0.75 8.0 0.2 2.0 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit 8 N-terminus Hist_deacetyl PF00850.19 ELR25013.1 - 3.2e-61 207.5 0.0 7.2e-61 206.3 0.0 1.6 1 1 0 1 1 1 1 Histone deacetylase domain BUD22 PF09073.10 ELR25013.1 - 0.00019 20.9 11.8 0.00027 20.4 11.8 1.1 1 0 0 1 1 1 1 BUD22 CNDH2_C PF16858.5 ELR25013.1 - 0.044 13.7 7.8 0.08 12.8 7.8 1.4 1 0 0 1 1 1 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term Cwf_Cwc_15 PF04889.12 ELR25013.1 - 0.091 12.5 20.9 0.16 11.7 20.9 1.3 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Pox_Ag35 PF03286.14 ELR25013.1 - 0.18 11.6 16.7 0.3 10.8 16.7 1.3 1 0 0 1 1 1 0 Pox virus Ag35 surface protein Zip PF02535.22 ELR25013.1 - 0.23 10.6 1.7 0.32 10.2 1.7 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Rrn6 PF10214.9 ELR25013.1 - 0.43 9.0 10.1 0.57 8.6 10.1 1.1 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor NPR3 PF03666.13 ELR25013.1 - 0.45 9.2 12.3 0.65 8.7 12.3 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 DUF908 PF06012.12 ELR25013.1 - 0.49 9.8 7.6 0.74 9.2 7.6 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF908) Nop14 PF04147.12 ELR25013.1 - 0.58 8.3 16.8 0.82 7.8 16.8 1.1 1 0 0 1 1 1 0 Nop14-like family DUF5427 PF10310.9 ELR25013.1 - 1 8.3 11.5 1.4 7.8 11.5 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5427) SpoIIIAH PF12685.7 ELR25013.1 - 1 9.1 9.4 1.6 8.5 9.4 1.2 1 0 0 1 1 1 0 SpoIIIAH-like protein DUF1168 PF06658.12 ELR25013.1 - 1.1 9.1 19.7 2.3 8.0 19.7 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1168) Afi1 PF07792.12 ELR25013.1 - 1.4 9.4 13.7 2.6 8.5 13.7 1.3 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking Macoilin PF09726.9 ELR25013.1 - 1.5 7.3 7.2 2 6.9 7.2 1.1 1 0 0 1 1 1 0 Macoilin family Ndc1_Nup PF09531.10 ELR25013.1 - 1.9 7.1 5.8 2.7 6.6 5.8 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup TFIIF_alpha PF05793.12 ELR25013.1 - 3.9 5.9 25.0 5.8 5.4 25.0 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) DNA_pol_phi PF04931.13 ELR25013.1 - 4.4 5.3 16.7 6.7 4.7 16.7 1.2 1 0 0 1 1 1 0 DNA polymerase phi PPP4R2 PF09184.11 ELR25013.1 - 4.5 6.8 17.9 6.3 6.3 17.9 1.1 1 0 0 1 1 1 0 PPP4R2 GREB1 PF15782.5 ELR25013.1 - 4.6 4.2 5.0 5.8 3.9 5.0 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer RR_TM4-6 PF06459.12 ELR25013.1 - 5 6.9 9.9 7.9 6.2 9.9 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 SAPS PF04499.15 ELR25013.1 - 5.6 5.6 8.3 7.8 5.2 8.3 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Vfa1 PF08432.10 ELR25013.1 - 6 7.2 17.9 9.5 6.5 17.9 1.2 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Presenilin PF01080.17 ELR25013.1 - 6 5.5 10.3 8.5 5.0 10.3 1.1 1 0 0 1 1 1 0 Presenilin DUF2857 PF11198.8 ELR25014.1 - 0.13 12.0 0.3 0.35 10.6 0.2 1.6 1 1 1 2 2 2 0 Protein of unknown function (DUF2857) MRVI1 PF05781.12 ELR25015.1 - 2.1 7.0 10.0 3.9 6.1 10.0 1.3 1 0 0 1 1 1 0 MRVI1 protein CDC45 PF02724.14 ELR25015.1 - 2.1 6.5 7.4 2.8 6.1 7.4 1.1 1 0 0 1 1 1 0 CDC45-like protein CAF20 PF17052.5 ELR25015.1 - 3.2 7.9 9.1 0.075 13.2 2.4 1.8 2 0 0 2 2 2 0 Cap associated factor Sporozoite_P67 PF05642.11 ELR25015.1 - 4.8 5.1 7.6 8.8 4.3 7.6 1.4 1 1 0 1 1 1 0 Sporozoite P67 surface antigen tRNA-synt_1e PF01406.19 ELR25016.1 - 3.8e-90 302.3 0.0 4.9e-90 301.9 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain tRNA-synt_1g PF09334.11 ELR25016.1 - 1.4e-05 24.0 0.0 0.0012 17.7 0.0 2.1 2 0 0 2 2 2 2 tRNA synthetases class I (M) tRNA-synt_1 PF00133.22 ELR25016.1 - 0.015 13.6 0.0 0.022 13.0 0.0 1.2 1 0 0 1 1 1 0 tRNA synthetases class I (I, L, M and V) GlgS PF08971.11 ELR25016.1 - 0.11 12.6 0.0 0.59 10.2 0.0 2.1 2 0 0 2 2 2 0 Glycogen synthesis protein tRNA-synt_1c PF00749.21 ELR25016.1 - 0.19 10.6 0.0 0.47 9.3 0.0 1.6 2 0 0 2 2 2 0 tRNA synthetases class I (E and Q), catalytic domain DUF29 PF01724.16 ELR25017.1 - 0.0054 17.0 0.1 0.0068 16.6 0.1 1.2 1 0 0 1 1 1 1 Domain of unknown function DUF29 TSC22 PF01166.18 ELR25017.1 - 0.0095 16.2 1.9 0.018 15.3 0.3 2.0 2 0 0 2 2 2 1 TSC-22/dip/bun family DUF4407 PF14362.6 ELR25017.1 - 0.027 13.8 1.2 0.029 13.7 1.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) FlxA PF14282.6 ELR25017.1 - 0.027 14.4 2.3 0.05 13.6 2.3 1.6 1 1 0 1 1 1 0 FlxA-like protein KELK PF15796.5 ELR25017.1 - 0.058 13.8 2.2 0.12 12.8 0.2 2.1 1 1 1 2 2 2 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase MerR-DNA-bind PF09278.11 ELR25017.1 - 0.069 13.7 0.4 0.19 12.3 0.1 1.8 2 0 0 2 2 2 0 MerR, DNA binding Sec2p PF06428.11 ELR25017.1 - 0.082 12.9 3.7 0.43 10.6 0.6 2.1 1 1 1 2 2 2 0 GDP/GTP exchange factor Sec2p Fer4_NifH PF00142.18 ELR25017.1 - 0.094 12.1 0.4 0.1 12.0 0.4 1.1 1 0 0 1 1 1 0 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family ZapB PF06005.12 ELR25017.1 - 0.097 13.1 3.3 0.14 12.7 3.3 1.3 1 0 0 1 1 1 0 Cell division protein ZapB Acetyltransf_11 PF13720.6 ELR25017.1 - 0.097 13.1 0.5 0.16 12.5 0.5 1.4 1 1 0 1 1 1 0 Udp N-acetylglucosamine O-acyltransferase; Domain 2 GTP_EFTU_D2 PF03144.25 ELR25017.1 - 0.098 13.1 0.4 0.17 12.3 0.4 1.5 1 1 0 1 1 1 0 Elongation factor Tu domain 2 TMPIT PF07851.13 ELR25017.1 - 0.13 11.4 0.3 0.16 11.2 0.3 1.0 1 0 0 1 1 1 0 TMPIT-like protein YabA PF06156.13 ELR25017.1 - 0.62 10.7 3.3 1.9 9.2 3.3 1.8 1 1 0 1 1 1 0 Initiation control protein YabA RNA_pol_I_A49 PF06870.12 ELR25018.1 - 4.5e-42 144.3 0.0 8.3e-42 143.4 0.0 1.4 1 0 0 1 1 1 1 A49-like RNA polymerase I associated factor Macoilin PF09726.9 ELR25018.1 - 2.2 6.8 6.7 3.6 6.0 6.7 1.3 1 0 0 1 1 1 0 Macoilin family Presenilin PF01080.17 ELR25018.1 - 4.3 6.0 6.3 7.3 5.2 6.3 1.3 1 0 0 1 1 1 0 Presenilin DEAD PF00270.29 ELR25019.1 - 1.7e-44 151.7 0.7 3e-44 150.9 0.1 1.7 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ELR25019.1 - 4.6e-29 101.0 1.5 2e-26 92.5 0.3 2.7 2 0 0 2 2 2 2 Helicase conserved C-terminal domain ResIII PF04851.15 ELR25019.1 - 6.1e-09 36.1 0.0 6.1e-09 36.1 0.0 2.8 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit CMS1 PF14617.6 ELR25019.1 - 0.00048 19.5 0.1 0.00048 19.5 0.1 4.2 2 1 2 4 4 4 1 U3-containing 90S pre-ribosomal complex subunit AAA_22 PF13401.6 ELR25019.1 - 0.0014 18.9 0.0 0.0048 17.2 0.0 1.9 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 ELR25019.1 - 0.0046 17.3 0.1 0.014 15.7 0.1 1.9 1 1 1 2 2 2 1 AAA domain SOBP PF15279.6 ELR25019.1 - 1.6 9.3 8.4 3 8.4 8.4 1.4 1 0 0 1 1 1 0 Sine oculis-binding protein Na_trans_assoc PF06512.13 ELR25019.1 - 1.6 8.9 26.4 3.8 7.7 26.4 1.6 1 0 0 1 1 1 0 Sodium ion transport-associated adh_short PF00106.25 ELR25020.1 - 9.2e-53 178.6 0.0 1.7e-52 177.7 0.0 1.4 2 0 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.6 ELR25020.1 - 5e-35 121.2 0.0 6.3e-35 120.8 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ELR25020.1 - 2e-12 47.4 0.0 2.9e-12 46.9 0.0 1.2 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 ELR25020.1 - 1.9e-05 23.9 0.1 0.00071 18.8 0.1 2.1 2 0 0 2 2 2 1 Polysaccharide biosynthesis protein RmlD_sub_bind PF04321.17 ELR25020.1 - 0.2 10.8 0.2 4 6.5 0.0 1.9 1 1 1 2 2 2 0 RmlD substrate binding domain UCH PF00443.29 ELR25021.1 - 8.8e-24 84.4 0.0 1.5e-23 83.7 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 ELR25021.1 - 1.7e-13 50.8 0.0 7e-13 48.8 0.0 2.0 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Phospho_p8 PF10195.9 ELR25021.1 - 1.6 9.3 9.1 6.3 7.4 9.1 2.0 1 0 0 1 1 1 0 DNA-binding nuclear phosphoprotein p8 SPX PF03105.19 ELR25021.1 - 4 7.2 6.4 3.4 7.5 4.6 1.6 2 0 0 2 2 2 0 SPX domain BRCA2 PF00634.18 ELR25023.1 - 1.2e-35 120.9 14.1 1e-05 25.1 0.0 9.4 9 0 0 9 9 9 8 BRCA2 repeat BRCA-2_OB1 PF09103.10 ELR25023.1 - 1.7e-30 105.5 0.0 3.5e-30 104.5 0.0 1.5 1 0 0 1 1 1 1 BRCA2, oligonucleotide/oligosaccharide-binding, domain 1 BRCA-2_helical PF09169.10 ELR25023.1 - 5.5e-25 88.1 0.0 3.7e-23 82.1 0.0 2.3 1 1 0 1 1 1 1 BRCA2, helical BRCA-2_OB3 PF09104.10 ELR25023.1 - 0.00023 20.8 0.0 0.00039 20.1 0.0 1.3 1 0 0 1 1 1 1 BRCA2, oligonucleotide/oligosaccharide-binding, domain 3 EcoEI_R_C PF08463.10 ELR25023.1 - 0.11 12.5 0.0 23 5.0 0.0 3.6 1 1 3 4 4 4 0 EcoEI R protein C-terminal Jagunal PF07086.12 ELR25024.1 - 7.1e-06 26.2 0.0 9.5e-06 25.8 0.0 1.3 1 1 0 1 1 1 1 Jagunal, ER re-organisation during oogenesis Ras PF00071.22 ELR25025.1 - 4.2e-55 185.8 0.0 5e-55 185.5 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR25025.1 - 4.6e-31 107.5 0.0 6.2e-31 107.1 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR25025.1 - 4e-11 42.7 0.0 4.6e-11 42.5 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 ELR25025.1 - 7.3e-06 26.0 0.0 1.1e-05 25.4 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 ELR25025.1 - 4.1e-05 23.5 0.0 0.012 15.5 0.0 2.1 2 0 0 2 2 2 2 RsgA GTPase Gtr1_RagA PF04670.12 ELR25025.1 - 0.00093 18.6 0.0 0.0011 18.4 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region ATP_bind_1 PF03029.17 ELR25025.1 - 0.0032 17.3 0.0 0.19 11.5 0.0 2.1 1 1 1 2 2 2 1 Conserved hypothetical ATP binding protein AAA_16 PF13191.6 ELR25025.1 - 0.0069 16.8 0.0 0.009 16.4 0.0 1.4 1 1 0 1 1 1 1 AAA ATPase domain AAA_7 PF12775.7 ELR25025.1 - 0.0079 15.7 0.0 0.011 15.2 0.0 1.2 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_24 PF13479.6 ELR25025.1 - 0.016 14.9 0.1 0.018 14.8 0.1 1.4 1 1 0 1 1 1 0 AAA domain AAA_22 PF13401.6 ELR25025.1 - 0.018 15.3 0.0 0.028 14.7 0.0 1.5 1 1 0 1 1 1 0 AAA domain ATPase_2 PF01637.18 ELR25025.1 - 0.037 13.9 0.0 0.048 13.6 0.0 1.4 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea ABC_tran PF00005.27 ELR25025.1 - 0.085 13.4 0.1 0.19 12.2 0.1 1.4 1 1 0 1 1 1 0 ABC transporter AAA_29 PF13555.6 ELR25025.1 - 0.085 12.6 0.0 0.19 11.5 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain Septin PF00735.18 ELR25025.1 - 0.11 11.8 0.0 0.18 11.0 0.0 1.4 1 0 0 1 1 1 0 Septin GTP_EFTU PF00009.27 ELR25025.1 - 0.11 12.0 0.0 0.23 11.0 0.0 1.6 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain DAP3 PF10236.9 ELR25025.1 - 0.25 10.5 0.0 0.34 10.0 0.0 1.2 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 PPR_3 PF13812.6 ELR25026.1 - 8.8e-54 179.5 0.1 8e-13 48.3 0.0 7.8 5 2 4 9 9 9 7 Pentatricopeptide repeat domain PPR_2 PF13041.6 ELR25026.1 - 1.2e-48 163.1 3.1 2.1e-11 43.8 0.1 9.1 6 2 4 10 10 10 8 PPR repeat family PPR_long PF17177.4 ELR25026.1 - 2.2e-33 115.4 8.8 7.9e-16 58.1 0.1 4.9 2 1 3 5 5 5 5 Pentacotripeptide-repeat region of PRORP PPR PF01535.20 ELR25026.1 - 6.3e-29 98.2 4.6 0.00018 21.5 0.0 9.5 10 0 0 10 10 10 7 PPR repeat PPR_1 PF12854.7 ELR25026.1 - 1.2e-24 85.6 2.4 0.0013 18.4 0.0 8.9 9 0 0 9 9 9 6 PPR repeat ECSIT PF06239.11 ELR25026.1 - 4e-05 22.9 3.6 0.012 14.7 0.0 5.0 6 0 0 6 6 6 1 Evolutionarily conserved signalling intermediate in Toll pathway TPR_19 PF14559.6 ELR25026.1 - 0.0032 17.9 2.1 1.6 9.3 0.0 4.4 4 1 1 5 5 5 1 Tetratricopeptide repeat Exog_C PF18026.1 ELR25026.1 - 0.036 14.1 1.4 18 5.5 0.0 4.2 6 0 0 6 6 6 0 Endo/exonuclease (EXOG) C-terminal domain SAP PF02037.27 ELR25027.1 - 7.1e-09 35.2 2.7 9.4e-08 31.6 0.7 2.9 3 1 0 3 3 3 1 SAP domain Macoilin PF09726.9 ELR25027.1 - 0.009 14.6 5.2 0.012 14.2 5.2 1.3 1 0 0 1 1 1 1 Macoilin family FANC_SAP PF18081.1 ELR25027.1 - 0.041 14.0 1.9 0.041 14.0 1.9 3.4 3 0 0 3 3 3 0 Fanconi anemia-associated nuclease SAP domain HeH PF12949.7 ELR25027.1 - 0.056 13.2 1.8 6.8 6.5 0.1 3.2 3 1 0 3 3 3 0 HeH/LEM domain SR-25 PF10500.9 ELR25027.1 - 0.51 9.9 26.8 9.6 5.7 26.8 2.3 1 1 0 1 1 1 0 Nuclear RNA-splicing-associated protein Ndc1_Nup PF09531.10 ELR25027.1 - 3 6.4 8.0 3.7 6.1 8.0 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup SAPS PF04499.15 ELR25027.1 - 3.8 6.2 8.0 5.9 5.6 8.0 1.2 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein DLIC PF05783.11 ELR25027.1 - 5.9 5.6 8.0 8.4 5.1 8.0 1.2 1 0 0 1 1 1 0 Dynein light intermediate chain (DLIC) CPBP PF02517.16 ELR25028.1 - 8.7e-09 35.6 3.1 8.7e-09 35.6 3.1 5.2 5 2 0 5 5 5 1 CPBP intramembrane metalloprotease DUF2909 PF11137.8 ELR25028.1 - 0.59 10.1 5.4 19 5.3 0.7 3.6 2 1 0 2 2 2 0 Protein of unknown function (DUF2909) HECT PF00632.25 ELR25029.1 - 1.8e-89 300.2 0.0 2.7e-89 299.7 0.0 1.3 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) Ldh_2 PF02615.14 ELR25030.1 - 1.8e-113 379.1 0.9 3e-113 378.4 0.9 1.4 1 0 0 1 1 1 1 Malate/L-lactate dehydrogenase TPX2_importin PF12214.8 ELR25030.1 - 5.1e-11 43.1 37.0 1.2e-07 32.1 11.7 4.0 3 1 1 4 4 4 3 Cell cycle regulated microtubule associated protein TPX2 PF06886.11 ELR25030.1 - 7.2e-11 42.2 19.1 7.2e-11 42.2 19.1 4.7 4 0 0 4 4 4 1 Targeting protein for Xklp2 (TPX2) YdfA_immunity PF12127.8 ELR25030.1 - 7.6 5.5 5.4 15 4.6 5.4 1.4 1 0 0 1 1 1 0 SigmaW regulon antibacterial Gln-synt_C PF00120.24 ELR25031.1 - 6.3e-16 58.3 0.0 1.2e-14 54.0 0.0 2.1 1 1 0 1 1 1 1 Glutamine synthetase, catalytic domain Gln-synt_N PF03951.19 ELR25031.1 - 2e-11 43.5 0.0 3.3e-11 42.8 0.0 1.4 1 0 0 1 1 1 1 Glutamine synthetase, beta-Grasp domain BNIP2 PF12496.8 ELR25032.1 - 7.6 7.0 10.8 1.5 9.3 5.2 2.1 2 0 0 2 2 2 0 Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2 IIGP PF05049.13 ELR25033.1 - 2.4e-42 145.3 0.0 4e-42 144.6 0.0 1.3 1 0 0 1 1 1 1 Interferon-inducible GTPase (IIGP) ABC_tran PF00005.27 ELR25033.1 - 3.9e-05 24.2 0.0 0.00011 22.7 0.0 1.7 2 0 0 2 2 1 1 ABC transporter MMR_HSR1 PF01926.23 ELR25033.1 - 0.00021 21.4 0.0 0.00053 20.0 0.0 1.8 1 1 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 ELR25033.1 - 0.00037 20.5 0.0 0.00066 19.6 0.0 1.4 1 0 0 1 1 1 1 RsgA GTPase AAA_29 PF13555.6 ELR25033.1 - 0.0014 18.3 0.0 0.0029 17.3 0.0 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_22 PF13401.6 ELR25033.1 - 0.0057 16.9 0.0 0.013 15.7 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_24 PF13479.6 ELR25033.1 - 0.006 16.3 0.0 0.0086 15.8 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_21 PF13304.6 ELR25033.1 - 0.0077 16.1 0.0 0.015 15.2 0.0 1.4 1 0 0 1 1 1 1 AAA domain, putative AbiEii toxin, Type IV TA system Roc PF08477.13 ELR25033.1 - 0.011 15.9 0.0 0.046 13.9 0.0 2.0 1 1 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase Septin PF00735.18 ELR25033.1 - 0.014 14.7 0.1 0.022 14.1 0.1 1.2 1 0 0 1 1 1 0 Septin Sigma54_activat PF00158.26 ELR25033.1 - 0.024 14.3 0.0 0.056 13.1 0.0 1.5 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_16 PF13191.6 ELR25033.1 - 0.032 14.6 0.0 0.098 13.0 0.0 1.8 1 0 0 1 1 1 0 AAA ATPase domain FtsK_SpoIIIE PF01580.18 ELR25033.1 - 0.035 13.4 0.0 0.062 12.6 0.0 1.3 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_28 PF13521.6 ELR25033.1 - 0.08 13.2 0.2 0.79 10.0 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_23 PF13476.6 ELR25033.1 - 0.086 13.3 0.1 0.14 12.7 0.1 1.3 1 0 0 1 1 1 0 AAA domain Dynamin_N PF00350.23 ELR25033.1 - 0.096 12.7 0.0 0.3 11.1 0.0 1.8 2 0 0 2 2 2 0 Dynamin family KAP_NTPase PF07693.14 ELR25033.1 - 0.14 11.4 0.0 0.25 10.6 0.0 1.4 1 0 0 1 1 1 0 KAP family P-loop domain NTPase_I-T PF01931.18 ELR25034.1 - 3.5e-37 127.7 0.1 2.7e-36 124.8 0.1 1.9 1 1 0 1 1 1 1 Protein of unknown function DUF84 YjeF_N PF03853.15 ELR25034.1 - 0.11 12.4 0.0 0.18 11.6 0.0 1.3 1 0 0 1 1 1 0 YjeF-related protein N-terminus DUF11 PF01345.18 ELR25034.1 - 0.14 12.5 0.0 0.26 11.6 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function DUF11 Methyltransf_25 PF13649.6 ELR25035.1 - 4.5e-08 33.7 0.0 1e-07 32.5 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ELR25035.1 - 6e-07 30.0 0.0 1.2e-06 29.0 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ELR25035.1 - 0.00013 22.6 0.0 0.00025 21.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 ELR25035.1 - 0.097 12.0 0.0 0.15 11.4 0.0 1.1 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family MTS PF05175.14 ELR25035.1 - 0.18 11.3 0.0 0.35 10.4 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase small domain TMEM189_B_dmain PF10520.9 ELR25036.1 - 4.3e-62 209.3 0.1 7.2e-62 208.6 0.1 1.3 1 0 0 1 1 1 1 B domain of TMEM189, localisation domain FA_hydroxylase PF04116.13 ELR25036.1 - 0.0073 16.6 4.9 0.01 16.2 3.2 1.9 1 1 1 2 2 2 1 Fatty acid hydroxylase superfamily HEAT PF02985.22 ELR25037.1 - 4.9e-07 29.5 3.5 3.3 8.2 0.0 5.7 5 0 0 5 5 5 3 HEAT repeat CLASP_N PF12348.8 ELR25037.1 - 0.00049 19.7 0.1 3.7 7.0 0.0 3.8 4 1 0 4 4 4 2 CLASP N terminal CENP-L PF13092.6 ELR25037.1 - 0.042 14.1 0.0 0.11 12.7 0.0 1.7 1 0 0 1 1 1 0 Kinetochore complex Sim4 subunit Fta1 SKA2 PF16740.5 ELR25037.1 - 0.11 12.3 2.4 0.29 10.9 2.4 1.7 1 0 0 1 1 1 0 Spindle and kinetochore-associated protein 2 DCB PF16213.5 ELR25037.1 - 0.13 11.9 0.8 0.34 10.5 0.1 2.1 2 0 0 2 2 2 0 Dimerisation and cyclophilin-binding domain of Mon2 DUF5364 PF17322.2 ELR25037.1 - 0.6 10.4 4.4 1.2 9.4 4.4 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5364) NHL PF01436.21 ELR25038.1 - 3.5e-54 178.2 29.2 5.4e-11 42.0 0.1 6.6 6 0 0 6 6 6 6 NHL repeat DUF5128 PF17170.4 ELR25038.1 - 2.6e-19 69.6 0.0 7.2e-06 25.4 0.0 3.1 1 1 2 3 3 3 3 6-bladed beta-propeller SGL PF08450.12 ELR25038.1 - 1.1e-10 41.6 14.8 0.0015 18.1 0.2 5.1 1 1 4 5 5 5 3 SMP-30/Gluconolactonase/LRE-like region zf-B_box PF00643.24 ELR25038.1 - 1.8e-09 37.6 22.9 8.6e-07 29.0 0.3 4.3 4 0 0 4 4 4 2 B-box zinc finger zf-RING_5 PF14634.6 ELR25038.1 - 1e-06 28.6 4.1 1e-06 28.6 4.1 2.9 3 0 0 3 3 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 ELR25038.1 - 1e-06 28.6 1.5 1e-06 28.6 1.5 2.1 2 0 0 2 2 1 1 RING-type zinc-finger Ldl_recept_b PF00058.17 ELR25038.1 - 2.4e-05 24.7 0.1 13 6.4 0.0 5.5 5 0 0 5 5 5 0 Low-density lipoprotein receptor repeat class B zf-RING_2 PF13639.6 ELR25038.1 - 4.3e-05 23.8 8.8 4.3e-05 23.8 8.8 4.0 3 1 0 3 3 2 1 Ring finger domain Arylesterase PF01731.20 ELR25038.1 - 0.00027 21.0 0.0 15 5.8 0.0 4.9 4 1 1 5 5 5 0 Arylesterase zf-C3HC4 PF00097.25 ELR25038.1 - 0.00032 20.5 5.5 0.00032 20.5 5.5 3.0 2 1 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 ELR25038.1 - 0.0013 18.6 2.1 0.0013 18.6 2.1 3.2 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 ELR25038.1 - 0.0039 17.3 1.7 0.0039 17.3 1.7 4.0 4 1 0 4 4 3 1 zinc finger of C3HC4-type, RING zf-C3HC4_3 PF13920.6 ELR25038.1 - 0.0084 16.0 0.8 0.0084 16.0 0.8 3.8 4 0 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) DUF4082 PF13313.6 ELR25038.1 - 0.015 15.4 2.4 1.5 8.9 0.1 3.5 2 1 2 4 4 4 0 Domain of unknown function (DUF4082) SBBP PF06739.11 ELR25038.1 - 0.019 14.9 0.0 14 5.8 0.1 3.1 3 0 0 3 3 2 0 Beta-propeller repeat TolB_like PF15869.5 ELR25038.1 - 0.026 13.8 0.0 0.19 10.9 0.0 2.1 1 1 2 3 3 3 0 TolB-like 6-blade propeller-like Phytase-like PF13449.6 ELR25038.1 - 0.051 13.5 0.2 2.2 8.2 0.0 2.7 1 1 1 2 2 2 0 Esterase-like activity of phytase IBR PF01485.21 ELR25038.1 - 0.076 13.3 20.7 4.7 7.5 0.5 4.6 4 0 0 4 4 4 0 IBR domain, a half RING-finger domain VCBS PF13517.6 ELR25038.1 - 0.13 12.9 10.5 4.5 7.9 0.4 5.0 2 1 3 5 5 5 0 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella Dynein_light PF01221.18 ELR25038.1 - 0.19 12.1 0.2 13 6.2 0.0 3.2 3 0 0 3 3 2 0 Dynein light chain type 1 DUF2321 PF10083.9 ELR25038.1 - 0.2 11.3 1.4 0.59 9.7 1.4 1.8 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2321) FYVE PF01363.21 ELR25038.1 - 0.37 11.0 24.2 3.1e+03 -1.6 0.0 3.5 2 1 0 2 2 2 0 FYVE zinc finger ubiquitin PF00240.23 ELR25039.1 - 3.3e-18 65.2 0.0 3.7e-18 65.0 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 ELR25039.1 - 2.8e-05 23.9 0.0 3.2e-05 23.7 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_4 PF18036.1 ELR25039.1 - 0.009 16.0 0.1 1.9 8.6 0.1 2.0 2 0 0 2 2 2 2 Ubiquitin-like domain Ubiquitin_2 PF14560.6 ELR25039.1 - 0.027 14.9 0.0 0.11 13.0 0.0 1.8 1 1 0 1 1 1 0 Ubiquitin-like domain MCM3AP_GANP PF16769.5 ELR25039.1 - 0.055 11.7 0.0 0.058 11.7 0.0 1.0 1 0 0 1 1 1 0 MCM3AP domain of GANP zf-B_box PF00643.24 ELR25039.1 - 0.056 13.6 1.3 0.073 13.2 1.3 1.2 1 0 0 1 1 1 0 B-box zinc finger RNA_pol_Rpb1_5 PF04998.17 ELR25041.1 - 1.5e-35 122.9 0.0 3.2e-35 121.9 0.0 1.2 1 1 0 1 1 1 1 RNA polymerase Rpb1, domain 5 PH PF00169.29 ELR25042.1 - 0.0031 18.0 0.0 0.0069 16.9 0.0 1.6 1 0 0 1 1 1 1 PH domain PLDc_2 PF13091.6 ELR25043.1 - 3.4e-11 43.1 3.2 1.4e-10 41.2 0.1 3.5 3 1 0 3 3 3 1 PLD-like domain PLDc PF00614.22 ELR25043.1 - 1.5e-09 37.6 1.7 0.00024 21.2 0.1 3.1 2 1 0 2 2 2 2 Phospholipase D Active site motif COX16 PF14138.6 ELR25044.1 - 7.3e-18 64.9 0.2 1.2e-17 64.1 0.2 1.4 1 0 0 1 1 1 1 Cytochrome c oxidase assembly protein COX16 SurA_N_2 PF13623.6 ELR25044.1 - 0.0038 17.1 0.1 0.0052 16.7 0.1 1.2 1 0 0 1 1 1 1 SurA N-terminal domain SurA_N_3 PF13624.6 ELR25044.1 - 0.013 15.3 0.3 0.022 14.6 0.0 1.5 2 0 0 2 2 2 0 SurA N-terminal domain WH1 PF00568.23 ELR25045.1 - 1e-21 76.9 0.1 1.7e-21 76.3 0.1 1.3 1 0 0 1 1 1 1 WH1 domain TPPK_C PF12555.8 ELR25045.1 - 0.092 12.8 0.8 0.22 11.6 0.8 1.7 1 0 0 1 1 1 0 Thiamine pyrophosphokinase C terminal PknH_C PF14032.6 ELR25045.1 - 1.1 9.1 6.2 1.6 8.6 0.9 2.7 3 0 0 3 3 3 0 PknH-like extracellular domain HATPase_c PF02518.26 ELR25046.1 - 1.6e-25 89.8 0.0 3.1e-25 88.9 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 ELR25046.1 - 1.8e-24 86.0 0.0 3.4e-24 85.2 0.0 1.5 1 0 0 1 1 1 1 Response regulator receiver domain HisKA PF00512.25 ELR25046.1 - 5.5e-17 61.6 0.3 2e-16 59.8 0.1 2.2 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain Metallophos PF00149.28 ELR25047.1 - 7.7e-21 75.5 0.1 1.1e-20 75.1 0.1 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 ELR25047.1 - 0.00067 19.9 0.0 0.012 15.8 0.0 2.1 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain AMP-binding PF00501.28 ELR25048.1 - 8.3e-84 281.6 0.1 1.4e-82 277.6 0.1 2.0 1 1 0 1 1 1 1 AMP-binding enzyme ACAS_N PF16177.5 ELR25048.1 - 9.4e-22 76.7 2.4 9.4e-22 76.7 2.4 1.8 2 0 0 2 2 2 1 Acetyl-coenzyme A synthetase N-terminus AMP-binding_C PF13193.6 ELR25048.1 - 2.6e-12 47.5 0.0 7.5e-12 46.1 0.0 1.8 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Glycos_transf_2 PF00535.26 ELR25049.1 - 1.6e-26 93.1 0.0 2.1e-26 92.7 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 ELR25049.1 - 5.4e-11 42.8 0.1 6.9e-11 42.5 0.1 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_2 PF10111.9 ELR25049.1 - 7.5e-06 25.6 0.0 1e-05 25.2 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_4 PF13704.6 ELR25049.1 - 0.0028 18.2 0.0 0.0057 17.1 0.0 1.6 1 0 0 1 1 1 1 Glycosyl transferase family 2 PsbX PF06596.11 ELR25050.1 - 0.29 11.2 3.7 0.32 11.0 3.1 1.5 1 1 0 1 1 1 0 Photosystem II reaction centre X protein (PsbX) Pro_isomerase PF00160.21 ELR25052.1 - 3.1e-49 167.3 0.0 1e-48 165.6 0.0 1.9 2 0 0 2 2 2 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Rtf2 PF04641.12 ELR25052.1 - 9e-11 41.6 2.5 1e-09 38.2 0.4 2.5 2 1 0 2 2 2 1 Rtf2 RING-finger zf-Nse PF11789.8 ELR25052.1 - 0.0069 16.2 0.2 0.17 11.7 0.1 2.4 2 0 0 2 2 2 1 Zinc-finger of the MIZ type in Nse subunit zf-NOSIP PF15906.5 ELR25052.1 - 0.12 12.5 0.0 0.31 11.2 0.0 1.7 1 0 0 1 1 1 0 Zinc-finger of nitric oxide synthase-interacting protein DUF3439 PF11921.8 ELR25052.1 - 1.2 9.1 4.7 3.2 7.7 4.7 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) MGC-24 PF05283.11 ELR25052.1 - 1.8 9.0 6.7 3.2 8.2 6.7 1.3 1 0 0 1 1 1 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin Nucleotid_trans PF03407.16 ELR25053.1 - 6.9e-27 94.8 0.3 3.6e-26 92.5 0.1 2.0 1 1 1 2 2 2 1 Nucleotide-diphospho-sugar transferase CBM49 PF09478.10 ELR25054.1 - 2.7e-26 91.7 4.5 2.1e-12 47.2 0.8 3.1 3 0 0 3 3 3 3 Carbohydrate binding domain CBM49 CBM_2 PF00553.19 ELR25054.1 - 3e-13 49.9 18.7 4.2e-06 27.0 1.2 3.8 3 2 0 3 3 3 3 Cellulose binding domain DUF756 PF05506.12 ELR25054.1 - 0.021 15.8 0.2 7.4 7.6 0.0 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF756) DUF4352 PF11611.8 ELR25054.1 - 0.061 13.6 0.1 3.4 8.0 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4352) DUF11 PF01345.18 ELR25054.1 - 0.26 11.6 12.7 5 7.5 5.5 3.7 3 1 0 3 3 3 0 Domain of unknown function DUF11 Snurportin1 PF11538.8 ELR25055.1 - 0.00013 22.1 6.5 0.00013 22.1 6.5 2.3 2 0 0 2 2 2 1 Snurportin1 Pkinase_Tyr PF07714.17 ELR25056.1 - 2.4e-27 95.9 0.0 3.4e-27 95.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ELR25056.1 - 1.5e-17 63.8 0.0 2.3e-17 63.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain CENP-B_dimeris PF09026.10 ELR25056.1 - 0.59 10.6 6.6 2.5 8.5 6.6 2.1 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Clat_adaptor_s PF01217.20 ELR25057.1 - 7.5e-56 188.0 0.6 8.2e-56 187.9 0.6 1.0 1 0 0 1 1 1 1 Clathrin adaptor complex small chain MLANA PF14991.6 ELR25059.1 - 0.012 15.9 0.3 0.026 14.8 0.3 1.6 1 0 0 1 1 1 0 Protein melan-A PSI PF01437.25 ELR25059.1 - 0.013 16.1 19.8 0.013 16.1 19.8 1.8 2 0 0 2 2 1 0 Plexin repeat PRCC PF10253.9 ELR25059.1 - 0.013 16.3 0.0 0.019 15.8 0.0 1.2 1 0 0 1 1 1 0 Mitotic checkpoint regulator, MAD2B-interacting Comm PF15957.5 ELR25059.1 - 0.017 15.5 0.6 0.028 14.8 0.6 1.3 1 0 0 1 1 1 0 Commissureless DUF2569 PF10754.9 ELR25059.1 - 0.055 13.9 1.7 1 9.8 0.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2569) Mucin PF01456.17 ELR25059.1 - 0.058 13.4 12.2 0.21 11.5 2.7 2.3 2 0 0 2 2 2 0 Mucin-like glycoprotein EphA2_TM PF14575.6 ELR25059.1 - 0.093 13.6 0.0 0.35 11.8 0.0 1.9 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain ETRAMP PF09716.10 ELR25059.1 - 0.67 10.1 3.1 0.61 10.2 0.5 2.0 2 0 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) FAP PF07174.11 ELR25059.1 - 2.7 7.4 17.6 3.7 6.9 17.6 1.2 1 0 0 1 1 1 0 Fibronectin-attachment protein (FAP) LST1 PF05083.13 ELR25059.1 - 5 7.5 7.2 12 6.2 7.2 1.7 1 1 0 1 1 1 0 LST-1 protein Prominin PF05478.11 ELR25059.1 - 8.1 4.3 8.9 11 3.8 8.9 1.1 1 0 0 1 1 1 0 Prominin EMC3_TMCO1 PF01956.16 ELR25060.1 - 9.3 5.9 5.9 14 5.3 5.9 1.2 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like RFX_DNA_binding PF02257.15 ELR25061.1 - 1.4e-14 54.4 0.8 2.2e-14 53.8 0.3 1.6 2 0 0 2 2 2 1 RFX DNA-binding domain RFX_DNA_binding PF02257.15 ELR25062.1 - 5.1e-16 59.1 0.0 9e-16 58.3 0.0 1.3 1 0 0 1 1 1 1 RFX DNA-binding domain zinc_ribbon_2 PF13240.6 ELR25063.1 - 0.038 13.7 0.5 0.071 12.9 0.5 1.4 1 0 0 1 1 1 0 zinc-ribbon domain CbtA PF09490.10 ELR25064.1 - 0.00021 21.1 0.4 0.00021 21.1 0.4 2.6 1 1 2 3 3 3 1 Probable cobalt transporter subunit (CbtA) Croc_4 PF17691.1 ELR25064.1 - 0.023 14.7 0.0 0.04 14.0 0.0 1.3 1 0 0 1 1 1 0 Contingent replication of cDNA 4 zf-Di19 PF05605.12 ELR25065.1 - 0.00012 22.3 2.4 0.39 11.1 0.0 2.3 2 0 0 2 2 2 2 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_4 PF13894.6 ELR25065.1 - 0.00031 21.3 2.5 0.48 11.4 0.0 2.5 2 0 0 2 2 2 2 C2H2-type zinc finger Zn-C2H2_12 PF18112.1 ELR25065.1 - 0.0013 19.1 6.8 0.0056 17.1 0.1 2.5 2 0 0 2 2 2 1 Autophagy receptor zinc finger-C2H2 domain Prok-RING_4 PF14447.6 ELR25065.1 - 0.004 17.0 0.4 3.7 7.5 0.1 2.3 2 0 0 2 2 2 2 Prokaryotic RING finger family 4 Rad50_zn_hook PF04423.14 ELR25065.1 - 0.014 15.2 3.0 0.76 9.7 0.2 2.8 2 0 0 2 2 2 0 Rad50 zinc hook motif zf-C2H2 PF00096.26 ELR25065.1 - 0.036 14.5 3.0 6.3 7.5 1.3 2.5 2 0 0 2 2 2 0 Zinc finger, C2H2 type UBZ_FAAP20 PF15750.5 ELR25065.1 - 0.041 13.8 1.3 5.3 7.1 0.1 2.4 2 0 0 2 2 2 0 Ubiquitin-binding zinc-finger zf-C2H2_2 PF12756.7 ELR25065.1 - 0.17 12.3 0.9 24 5.3 0.3 2.3 2 0 0 2 2 2 0 C2H2 type zinc-finger (2 copies) TRAF6_Z2 PF18048.1 ELR25065.1 - 0.2 11.7 2.8 0.54 10.4 0.6 2.2 2 0 0 2 2 2 0 TNF receptor-associated factor 6 zinc finger 2 RNF220 PF15926.5 ELR25065.1 - 0.21 11.2 6.9 0.84 9.2 0.4 3.1 3 0 0 3 3 3 0 E3 ubiquitin-protein ligase RNF220 Spt20 PF12090.8 ELR25066.1 - 0.023 14.3 18.3 0.045 13.4 18.3 1.5 1 0 0 1 1 1 0 Spt20 family PAT1 PF09770.9 ELR25066.1 - 0.13 10.5 12.3 0.16 10.2 12.3 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 CSRNP_N PF16019.5 ELR25066.1 - 0.18 11.7 7.4 0.3 11.0 7.4 1.3 1 0 0 1 1 1 0 Cysteine/serine-rich nuclear protein N-terminus Presenilin PF01080.17 ELR25066.1 - 0.54 9.0 6.2 0.71 8.6 6.2 1.2 1 0 0 1 1 1 0 Presenilin Endostatin PF06482.11 ELR25066.1 - 0.55 9.6 12.4 0.068 12.6 8.4 1.5 2 0 0 2 2 2 0 Collagenase NC10 and Endostatin Neur_chan_memb PF02932.16 ELR25066.1 - 2.1 8.3 4.1 3.3 7.7 4.1 1.4 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region BRF1 PF07741.13 ELR25066.1 - 2.5 8.5 6.2 1.5 9.2 4.2 1.7 2 0 0 2 2 2 0 Brf1-like TBP-binding domain Zip PF02535.22 ELR25066.1 - 3.3 6.8 4.4 4.9 6.3 4.4 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter DUF2076 PF09849.9 ELR25066.1 - 3.5 7.6 35.5 0.048 13.7 1.7 3.2 3 0 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2076) Lin-8 PF03353.15 ELR25066.1 - 4.2 6.8 14.6 0.083 12.4 7.9 1.6 2 0 0 2 2 2 0 Ras-mediated vulval-induction antagonist T2SSC PF11356.8 ELR25066.1 - 4.4 7.2 5.9 2.4 8.0 3.1 1.9 2 0 0 2 2 2 0 Type II secretion system protein C Pentapeptide PF00805.22 ELR25067.1 - 2.4e-61 202.8 39.3 9.6e-12 44.3 2.9 6.5 1 1 3 6 6 6 6 Pentapeptide repeats (8 copies) Pentapeptide_4 PF13599.6 ELR25067.1 - 5.3e-30 103.4 0.0 1.5e-09 37.9 0.0 3.8 1 1 3 4 4 4 3 Pentapeptide repeats (9 copies) Pentapeptide_3 PF13576.6 ELR25067.1 - 1.1e-21 76.6 0.0 0.00013 22.0 0.0 5.3 1 1 3 5 5 5 5 Pentapeptide repeats (9 copies) DNA_ligase_OB PF03120.16 ELR25067.1 - 0.00032 20.5 5.4 23 5.0 0.1 6.0 2 1 3 6 6 6 2 NAD-dependent DNA ligase OB-fold domain MCPVI PF02993.14 ELR25067.1 - 0.069 13.0 1.1 0.46 10.3 0.0 2.5 3 0 0 3 3 3 0 Minor capsid protein VI TBCC PF07986.12 ELR25068.1 - 3.7e-39 133.1 0.1 4.3e-39 133.0 0.1 1.0 1 0 0 1 1 1 1 Tubulin binding cofactor C Synaptobrevin PF00957.21 ELR25069.1 - 3.1e-13 49.3 0.5 4.9e-13 48.7 0.5 1.3 1 0 0 1 1 1 1 Synaptobrevin Longin PF13774.6 ELR25069.1 - 7.6e-06 25.9 0.0 1.4e-05 25.1 0.0 1.5 1 0 0 1 1 1 1 Regulated-SNARE-like domain Nudix_hydro PF18290.1 ELR25070.1 - 2.6e-30 104.3 0.0 4.9e-30 103.3 0.0 1.5 1 0 0 1 1 1 1 Nudix hydrolase domain NUDIX PF00293.28 ELR25070.1 - 2.9e-16 59.7 0.4 3.1e-15 56.4 0.4 2.2 1 1 0 1 1 1 1 NUDIX domain Pyrid_ox_like PF16242.5 ELR25071.1 - 8.9e-10 38.3 0.0 1.2e-09 37.9 0.0 1.2 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase like Putative_PNPOx PF01243.20 ELR25071.1 - 1.8e-07 31.3 0.0 2.8e-07 30.6 0.0 1.3 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Peptidase_M16_C PF05193.21 ELR25072.1 - 7.6e-34 117.3 0.0 2.3e-33 115.7 0.0 1.8 2 0 0 2 2 2 1 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 ELR25072.1 - 1.9e-31 109.0 0.0 3e-31 108.4 0.0 1.3 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) Sas10_Utp3 PF04000.15 ELR25074.1 - 3.3e-15 56.5 0.2 3.3e-15 56.5 0.2 2.1 2 1 0 2 2 2 1 Sas10/Utp3/C1D family Fungal_trans_2 PF11951.8 ELR25074.1 - 0.0056 15.5 0.0 0.008 15.0 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain COG5 PF10392.9 ELR25074.1 - 0.0095 16.1 2.5 0.029 14.6 0.4 2.3 1 1 1 2 2 2 1 Golgi transport complex subunit 5 Phage_tail_APC PF16778.5 ELR25074.1 - 0.1 12.5 0.1 0.19 11.6 0.1 1.4 1 0 0 1 1 1 0 Phage tail assembly chaperone protein Clathrin_H_link PF13838.6 ELR25074.1 - 0.12 12.3 0.0 0.34 10.8 0.0 1.8 1 0 0 1 1 1 0 Clathrin-H-link Neur_chan_memb PF02932.16 ELR25074.1 - 1.3 9.1 3.3 1.7 8.7 3.3 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF1840 PF08895.11 ELR25074.1 - 1.7 9.0 11.3 2.9 8.3 0.0 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF1840) SKA1 PF07160.12 ELR25074.1 - 1.7 8.4 13.8 15 5.3 12.2 2.0 2 0 0 2 2 2 0 Spindle and kinetochore-associated protein 1 Presenilin PF01080.17 ELR25074.1 - 2.3 6.9 4.2 2.1 7.0 4.2 1.1 1 0 0 1 1 1 0 Presenilin FlaC_arch PF05377.11 ELR25074.1 - 5.8 7.4 7.8 6.9 7.1 0.4 2.8 3 1 0 3 3 3 0 Flagella accessory protein C (FlaC) JmjC PF02373.22 ELR25075.1 - 3.7e-09 37.0 0.0 1.5e-06 28.6 0.0 2.1 1 1 0 1 1 1 1 JmjC domain, hydroxylase Cupin_4 PF08007.12 ELR25075.1 - 7.7e-08 32.2 0.0 1e-07 31.8 0.0 1.1 1 0 0 1 1 1 1 Cupin superfamily protein Cupin_8 PF13621.6 ELR25075.1 - 0.0014 18.4 0.0 0.055 13.2 0.0 2.1 1 1 0 1 1 1 1 Cupin-like domain Cupin_1 PF00190.22 ELR25075.1 - 0.027 14.1 0.0 0.036 13.7 0.0 1.2 1 0 0 1 1 1 0 Cupin eRF1_2 PF03464.15 ELR25076.1 - 0.013 15.8 0.0 0.02 15.2 0.0 1.3 1 0 0 1 1 1 0 eRF1 domain 2 eRF1_3 PF03465.15 ELR25076.1 - 0.12 12.9 0.0 0.18 12.3 0.0 1.3 1 0 0 1 1 1 0 eRF1 domain 3 Med26 PF08711.11 ELR25077.1 - 1.2e-15 57.2 0.6 3.2e-15 55.9 0.2 2.0 2 0 0 2 2 2 1 TFIIS helical bundle-like domain Myb_DNA-bind_3 PF12776.7 ELR25077.1 - 0.46 11.5 0.1 0.46 11.5 0.1 2.7 3 0 0 3 3 3 0 Myb/SANT-like DNA-binding domain YkyA PF10368.9 ELR25079.1 - 0.049 13.3 5.5 0.075 12.7 5.5 1.3 1 0 0 1 1 1 0 Putative cell-wall binding lipoprotein APG6_N PF17675.1 ELR25079.1 - 4.4 7.8 9.9 9.5 6.8 9.9 1.5 1 0 0 1 1 1 0 Apg6 coiled-coil region HlyIII PF03006.20 ELR25080.1 - 1.5e-47 162.2 24.9 2.6e-47 161.4 24.9 1.4 1 1 0 1 1 1 1 Haemolysin-III related Transketolase_N PF00456.21 ELR25081.1 - 1e-158 527.6 0.0 1.4e-158 527.2 0.0 1.2 1 0 0 1 1 1 1 Transketolase, thiamine diphosphate binding domain Transket_pyr PF02779.24 ELR25081.1 - 1.1e-41 142.5 0.0 2.7e-41 141.2 0.0 1.6 2 0 0 2 2 2 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.20 ELR25081.1 - 2.8e-07 30.4 0.0 2.3e-05 24.2 0.0 2.5 2 0 0 2 2 2 1 Transketolase, C-terminal domain DXP_synthase_N PF13292.6 ELR25081.1 - 1.8e-05 24.1 0.0 0.00014 21.2 0.0 2.0 1 1 1 2 2 2 1 1-deoxy-D-xylulose-5-phosphate synthase TPP_enzyme_C PF02775.21 ELR25081.1 - 0.00068 19.4 0.4 0.0034 17.2 0.1 2.3 2 1 0 2 2 2 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain Lant_dehydr_C PF14028.6 ELR25081.1 - 0.053 13.0 0.0 0.09 12.3 0.0 1.2 1 0 0 1 1 1 0 Lantibiotic biosynthesis dehydratase C-term Terpene_synth PF01397.21 ELR25081.1 - 0.16 11.6 0.0 0.31 10.7 0.0 1.3 1 0 0 1 1 1 0 Terpene synthase, N-terminal domain RFX_DNA_binding PF02257.15 ELR25082.1 - 2.6e-19 69.6 0.0 3.8e-19 69.1 0.0 1.3 1 0 0 1 1 1 1 RFX DNA-binding domain RFX_DNA_binding PF02257.15 ELR25083.1 - 1.6e-06 28.6 0.0 2.7e-06 27.9 0.0 1.3 1 0 0 1 1 1 1 RFX DNA-binding domain zf-RING_UBOX PF13445.6 ELR25084.1 - 2.3e-08 33.9 5.2 3.8e-08 33.2 2.6 2.4 1 1 1 2 2 2 1 RING-type zinc-finger zf-C3HC4 PF00097.25 ELR25084.1 - 4.5e-08 32.8 6.8 8.7e-08 31.9 6.8 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 ELR25084.1 - 3e-07 30.2 7.7 1.5e-06 27.9 8.1 2.0 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 ELR25084.1 - 3.1e-07 30.6 7.5 5.7e-07 29.8 7.5 1.5 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_3 PF13920.6 ELR25084.1 - 1e-06 28.5 5.4 1.9e-06 27.6 5.4 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ELR25084.1 - 1.4e-06 28.1 6.0 3.2e-06 27.0 6.0 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_4 PF15227.6 ELR25084.1 - 2e-06 27.9 6.7 3.9e-06 26.9 6.7 1.5 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING Prok-RING_4 PF14447.6 ELR25084.1 - 0.0035 17.2 4.7 0.007 16.2 4.7 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-Nse PF11789.8 ELR25084.1 - 0.0075 16.1 2.8 0.015 15.1 2.8 1.5 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_10 PF16685.5 ELR25084.1 - 0.032 14.3 2.9 0.063 13.4 2.9 1.4 1 0 0 1 1 1 0 zinc RING finger of MSL2 zf-rbx1 PF12678.7 ELR25084.1 - 0.059 13.7 5.1 0.14 12.5 5.1 1.7 1 0 0 1 1 1 0 RING-H2 zinc finger domain zf-C3HC4_5 PF17121.5 ELR25084.1 - 2.4 8.1 5.1 26 4.8 4.7 2.5 2 1 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-MIZ PF02891.20 ELR25084.1 - 5.1 6.9 10.3 17 5.2 9.9 2.0 1 1 1 2 2 2 0 MIZ/SP-RING zinc finger BP28CT PF08146.12 ELR25085.1 - 1.6e-26 93.1 14.1 2e-17 63.5 2.0 5.2 4 1 1 5 5 5 2 BP28CT (NUC211) domain U3snoRNP10 PF12397.8 ELR25085.1 - 5e-16 59.1 4.1 5e-16 59.1 4.1 5.7 5 1 0 5 5 5 1 U3 small nucleolar RNA-associated protein 10 HEAT_EZ PF13513.6 ELR25085.1 - 8.3e-05 23.0 0.0 9.6 6.8 0.0 5.8 5 0 0 5 5 5 2 HEAT-like repeat Cohesin_HEAT PF12765.7 ELR25085.1 - 0.38 11.1 2.6 0.96 9.8 0.1 2.8 3 0 0 3 3 3 0 HEAT repeat associated with sister chromatid cohesion Pkinase PF00069.25 ELR25086.1 - 8.9e-61 205.6 0.0 1.8e-60 204.5 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR25086.1 - 4.9e-45 153.8 0.0 1e-44 152.8 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase DEP PF00610.21 ELR25086.1 - 1.3e-35 121.3 0.6 2.1e-18 66.2 0.0 3.2 3 0 0 3 3 3 2 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) Kinase-like PF14531.6 ELR25086.1 - 0.016 14.5 0.0 0.03 13.7 0.0 1.3 1 0 0 1 1 1 0 Kinase-like Haspin_kinase PF12330.8 ELR25086.1 - 0.037 13.0 0.0 0.072 12.0 0.0 1.4 1 0 0 1 1 1 0 Haspin like kinase domain HATPase_c PF02518.26 ELR25087.1 - 9.5e-30 103.4 0.0 1.8e-29 102.5 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 ELR25087.1 - 3.1e-23 82.1 0.4 3.5e-14 52.9 0.1 2.6 2 0 0 2 2 2 2 Response regulator receiver domain HisKA PF00512.25 ELR25087.1 - 2.4e-05 24.3 0.1 0.00012 22.1 0.1 2.2 1 1 0 1 1 1 1 His Kinase A (phospho-acceptor) domain HATPase_c_3 PF13589.6 ELR25087.1 - 0.11 12.3 0.4 0.35 10.7 0.0 1.9 2 0 0 2 2 2 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase F-box-like PF12937.7 ELR25088.1 - 0.00052 19.9 0.1 0.0019 18.1 0.0 1.9 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 ELR25088.1 - 0.0055 16.6 0.1 0.014 15.3 0.1 1.6 1 0 0 1 1 1 1 F-box domain Sox_N PF12444.8 ELR25088.1 - 0.053 14.6 4.5 2.4 9.3 0.0 3.2 2 0 0 2 2 2 0 Sox developmental protein N terminal HATPase_c PF02518.26 ELR25089.1 - 1e-27 96.8 0.1 1.9e-27 95.9 0.1 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 ELR25089.1 - 8.8e-16 57.7 0.1 2e-15 56.6 0.1 1.7 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain Response_reg PF00072.24 ELR25089.1 - 1.3e-11 44.6 0.8 7.7e-07 29.3 0.0 3.7 3 1 1 4 4 4 3 Response regulator receiver domain K_channel_TID PF07941.11 ELR25089.1 - 0.23 12.0 0.2 0.23 12.0 0.2 2.1 2 0 0 2 2 2 0 Potassium channel Kv1.4 tandem inactivation domain PH PF00169.29 ELR25090.1 - 7.2e-07 29.7 0.3 1.1e-06 29.1 0.3 1.3 1 0 0 1 1 1 1 PH domain TerD PF02342.18 ELR25090.1 - 0.14 11.7 0.1 0.21 11.0 0.1 1.2 1 0 0 1 1 1 0 TerD domain LRR_8 PF13855.6 ELR25091.1 - 1.3e-46 156.1 44.5 3.6e-08 33.0 1.6 7.6 2 1 3 8 8 8 8 Leucine rich repeat LRR_4 PF12799.7 ELR25091.1 - 2.9e-40 135.6 59.8 1.4e-07 31.7 0.5 10.9 4 2 6 12 12 12 10 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 ELR25091.1 - 2.3e-15 54.7 45.7 0.31 11.8 0.0 14.9 17 1 0 17 17 17 7 Leucine Rich Repeat LRR_9 PF14580.6 ELR25091.1 - 4.8e-11 42.5 27.1 7.6e-08 32.0 0.6 5.4 1 1 5 6 6 6 3 Leucine-rich repeat LRR_6 PF13516.6 ELR25091.1 - 0.1 12.7 49.5 1.5 9.0 0.4 11.7 13 0 0 13 13 13 0 Leucine Rich repeat TSC22 PF01166.18 ELR25091.1 - 0.33 11.3 3.0 2.4 8.5 0.1 3.6 3 0 0 3 3 3 0 TSC-22/dip/bun family CheY-binding PF09078.11 ELR25091.1 - 0.63 10.2 11.0 3.5 7.8 0.0 5.3 6 0 0 6 6 6 0 CheY binding Big_3_5 PF16640.5 ELR25093.1 - 0.03 14.5 1.2 0.07 13.3 1.2 1.6 1 0 0 1 1 1 0 Bacterial Ig-like domain (group 3) SET PF00856.28 ELR25095.1 - 2.6e-13 50.7 0.0 4.4e-13 50.0 0.0 1.5 1 0 0 1 1 1 1 SET domain zf-MYND PF01753.18 ELR25095.1 - 1.5e-05 25.0 2.5 1.5e-05 25.0 2.5 2.1 2 0 0 2 2 2 1 MYND finger TPR_12 PF13424.6 ELR25095.1 - 0.0018 18.5 0.4 1.6 9.0 0.0 3.1 2 1 1 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 ELR25095.1 - 6.6 7.1 7.4 6.3 7.2 0.4 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat RasGEF PF00617.19 ELR25096.1 - 2.5e-45 154.9 0.1 3.8e-45 154.3 0.1 1.3 1 0 0 1 1 1 1 RasGEF domain PI_PP_I PF18363.1 ELR25096.1 - 0.079 13.1 1.6 0.41 10.8 0.3 2.4 2 0 0 2 2 2 0 Phosphoinositide phosphatase insertion domain Trypsin PF00089.26 ELR25097.1 - 0.11 12.3 0.1 9.4 6.0 0.0 2.3 2 0 0 2 2 2 0 Trypsin DUF4918 PF16265.5 ELR25098.1 - 4.2e-06 26.4 0.0 0.028 13.9 0.0 2.4 2 1 0 2 2 2 2 Domain of unknown function (DUF4918) UDG PF03167.19 ELR25098.1 - 0.0015 18.5 0.1 0.078 13.0 0.1 2.2 1 1 0 1 1 1 1 Uracil DNA glycosylase superfamily ThiF PF00899.21 ELR25099.1 - 2.2e-65 220.4 0.0 3e-65 220.0 0.0 1.1 1 0 0 1 1 1 1 ThiF family E2_bind PF08825.10 ELR25099.1 - 5.8e-19 68.0 0.0 8.8e-19 67.4 0.0 1.3 1 0 0 1 1 1 1 E2 binding domain UBA_e1_thiolCys PF10585.9 ELR25099.1 - 0.14 12.1 0.1 4.9 7.0 0.0 2.1 2 0 0 2 2 2 0 Ubiquitin-activating enzyme active site TMEM164 PF14808.6 ELR25100.1 - 3.7e-17 62.5 12.0 1.8e-15 57.0 3.7 2.1 1 1 1 2 2 2 2 TMEM164 family CDO_I PF05995.12 ELR25101.1 - 7.5e-27 93.7 0.0 1e-26 93.3 0.0 1.1 1 0 0 1 1 1 1 Cysteine dioxygenase type I PCO_ADO PF07847.12 ELR25101.1 - 9.2e-05 22.0 0.3 0.00017 21.1 0.0 1.5 2 0 0 2 2 2 1 PCO_ADO DUF2811 PF10929.8 ELR25101.1 - 0.18 12.1 0.0 0.35 11.2 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2811) CCDC50_N PF15295.6 ELR25103.1 - 0.077 13.2 6.5 0.14 12.4 6.5 1.3 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 50 N-terminus Gly-zipper_YMGG PF13441.6 ELR25103.1 - 0.42 10.4 27.9 0.46 10.3 16.8 2.2 2 0 0 2 2 2 0 YMGG-like Gly-zipper Rick_17kDa_Anti PF05433.15 ELR25103.1 - 1.5 8.7 22.0 2.8 7.9 11.3 2.5 2 0 0 2 2 2 0 Glycine zipper 2TM domain Gly-zipper_OmpA PF13436.6 ELR25103.1 - 4.3 7.2 31.3 1.3 8.9 19.6 2.2 2 0 0 2 2 2 0 Glycine-zipper domain Romo1 PF10247.9 ELR25103.1 - 7.8 7.0 12.7 0.94 9.9 0.4 2.3 2 0 0 2 2 2 0 Reactive mitochondrial oxygen species modulator 1 adh_short PF00106.25 ELR25104.1 - 2.8e-43 147.6 0.1 3.5e-43 147.3 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ELR25104.1 - 1.3e-42 146.0 0.1 2.8e-42 144.9 0.1 1.5 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ELR25104.1 - 3.2e-12 46.7 0.0 6.5e-12 45.7 0.1 1.4 2 0 0 2 2 2 1 KR domain Polysacc_synt_2 PF02719.15 ELR25104.1 - 0.015 14.4 0.0 0.028 13.6 0.0 1.4 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein CTNNBL PF08216.11 ELR25104.1 - 0.051 13.7 0.0 0.11 12.7 0.0 1.5 1 0 0 1 1 1 0 Catenin-beta-like, Arm-motif containing nuclear adh_short PF00106.25 ELR25107.1 - 0.00028 20.4 0.1 0.00032 20.2 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ELR25107.1 - 0.04 13.5 0.1 0.045 13.3 0.1 1.1 1 0 0 1 1 1 0 Enoyl-(Acyl carrier protein) reductase TLE_N PF03920.15 ELR25107.1 - 0.076 13.1 0.0 0.087 12.9 0.0 1.1 1 0 0 1 1 1 0 Groucho/TLE N-terminal Q-rich domain SH3_9 PF14604.6 ELR25108.1 - 9.5e-09 35.0 0.1 1.8e-08 34.1 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 ELR25108.1 - 5.9e-08 32.2 0.1 1e-07 31.5 0.1 1.4 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 ELR25108.1 - 1.5e-06 27.8 0.1 3.9e-06 26.4 0.0 1.8 2 0 0 2 2 2 1 Variant SH3 domain LMBR1 PF04791.16 ELR25109.1 - 2.1 7.1 0.0 2.1 7.1 0.0 4.1 2 1 2 4 4 4 0 LMBR1-like membrane protein Hemagglutinin PF00509.18 ELR25109.1 - 3 6.1 5.2 5.6 5.2 5.2 1.4 1 0 0 1 1 1 0 Haemagglutinin Laminin_G_3 PF13385.6 ELR25110.1 - 1e-11 45.2 0.0 1.3e-11 44.9 0.0 1.2 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily SRP54 PF00448.22 ELR25111.1 - 9.2e-79 263.6 1.1 2.2e-78 262.4 1.1 1.7 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain SRP_SPB PF02978.19 ELR25111.1 - 2.7e-30 104.9 2.6 2.7e-30 104.9 2.6 3.1 3 0 0 3 3 3 1 Signal peptide binding domain SRP54_N PF02881.19 ELR25111.1 - 1.2e-16 60.6 3.5 3.7e-16 59.1 3.5 1.9 1 0 0 1 1 1 1 SRP54-type protein, helical bundle domain AAA_33 PF13671.6 ELR25111.1 - 2.3e-06 27.9 0.0 4.5e-06 26.9 0.0 1.5 1 0 0 1 1 1 1 AAA domain Zeta_toxin PF06414.12 ELR25111.1 - 7.7e-05 22.1 0.0 0.00019 20.8 0.0 1.7 1 0 0 1 1 1 1 Zeta toxin AAA_16 PF13191.6 ELR25111.1 - 0.00012 22.5 0.0 0.00032 21.1 0.0 1.7 2 0 0 2 2 1 1 AAA ATPase domain cobW PF02492.19 ELR25111.1 - 0.00022 20.8 1.2 0.00089 18.9 0.5 2.2 2 1 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain AAA_17 PF13207.6 ELR25111.1 - 0.00026 21.4 1.4 0.0015 19.0 0.1 2.5 2 0 0 2 2 2 1 AAA domain MMR_HSR1 PF01926.23 ELR25111.1 - 0.0023 18.0 0.1 0.011 15.9 0.1 2.2 1 1 0 1 1 1 1 50S ribosome-binding GTPase ResIII PF04851.15 ELR25111.1 - 0.0027 17.7 0.9 0.0051 16.8 0.3 1.8 2 0 0 2 2 1 1 Type III restriction enzyme, res subunit MeaB PF03308.16 ELR25111.1 - 0.0029 16.6 0.2 0.068 12.1 0.1 2.8 2 1 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB SRPRB PF09439.10 ELR25111.1 - 0.0037 16.7 0.2 0.98 8.8 0.1 2.6 1 1 1 2 2 2 1 Signal recognition particle receptor beta subunit AAA_30 PF13604.6 ELR25111.1 - 0.0067 16.2 0.1 0.014 15.1 0.1 1.6 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 ELR25111.1 - 0.033 14.5 0.1 0.098 13.0 0.1 1.9 1 1 0 1 1 1 0 AAA domain AAA_28 PF13521.6 ELR25111.1 - 0.042 14.1 0.1 0.088 13.0 0.1 1.6 1 1 0 1 1 1 0 AAA domain HAUS2 PF15003.6 ELR25111.1 - 0.05 13.3 0.2 0.11 12.2 0.2 1.6 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 2 APS_kinase PF01583.20 ELR25111.1 - 0.054 13.4 0.0 0.099 12.5 0.0 1.4 1 0 0 1 1 1 0 Adenylylsulphate kinase AAA_22 PF13401.6 ELR25111.1 - 0.058 13.7 0.1 0.19 12.0 0.1 1.9 1 1 0 1 1 1 0 AAA domain AAA_18 PF13238.6 ELR25111.1 - 0.058 14.0 0.4 0.39 11.3 0.0 2.5 3 0 0 3 3 2 0 AAA domain VirC1 PF07015.11 ELR25111.1 - 0.066 12.5 0.0 0.13 11.5 0.0 1.4 1 0 0 1 1 1 0 VirC1 protein CbiA PF01656.23 ELR25111.1 - 0.069 13.2 0.0 0.19 11.8 0.0 2.0 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain MobB PF03205.14 ELR25111.1 - 0.07 13.0 0.8 0.27 11.1 0.0 2.3 3 0 0 3 3 3 0 Molybdopterin guanine dinucleotide synthesis protein B Arf PF00025.21 ELR25111.1 - 0.078 12.4 0.0 0.19 11.1 0.0 1.6 1 0 0 1 1 1 0 ADP-ribosylation factor family TrkA_N PF02254.18 ELR25111.1 - 0.086 13.1 0.4 2.5 8.4 0.1 2.4 2 0 0 2 2 2 0 TrkA-N domain Nup35_RRM PF05172.13 ELR25111.1 - 0.093 12.7 0.1 0.43 10.6 0.0 2.1 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif DUF2209 PF09974.9 ELR25111.1 - 0.094 13.1 0.1 0.34 11.3 0.1 2.0 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2209) AAA_24 PF13479.6 ELR25111.1 - 0.12 12.1 0.5 0.4 10.4 0.1 2.0 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.6 ELR25111.1 - 0.17 11.4 0.2 0.67 9.5 0.2 2.0 1 1 0 1 1 1 0 AAA domain ArsA_ATPase PF02374.15 ELR25111.1 - 0.5 9.5 4.6 2 7.5 0.0 2.7 3 0 0 3 3 3 0 Anion-transporting ATPase AAA PF00004.29 ELR25111.1 - 2 8.9 4.5 2.1 8.8 0.2 3.2 3 2 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) SIR2 PF02146.17 ELR25114.1 - 7.7e-24 84.6 0.0 1.1e-23 84.0 0.0 1.3 1 0 0 1 1 1 1 Sir2 family TPP_enzyme_M PF00205.22 ELR25114.1 - 0.0098 15.6 0.0 0.14 11.9 0.0 2.2 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, central domain Zn-ribbon_8 PF09723.10 ELR25114.1 - 0.049 13.7 1.5 0.17 12.0 1.5 2.0 1 0 0 1 1 1 0 Zinc ribbon domain Ribosomal_L4 PF00573.22 ELR25115.1 - 9.3e-42 142.9 0.4 9.3e-42 142.9 0.4 1.7 2 0 0 2 2 2 1 Ribosomal protein L4/L1 family Ribos_L4_asso_C PF14374.6 ELR25115.1 - 1.8e-26 91.9 8.8 2.4e-26 91.6 4.2 2.7 2 0 0 2 2 2 1 60S ribosomal protein L4 C-terminal domain RasGEF PF00617.19 ELR25116.1 - 1.9e-47 161.8 0.0 4.4e-47 160.6 0.0 1.6 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 ELR25116.1 - 2.6e-12 46.9 3.5 6.4e-11 42.4 0.3 3.5 3 1 0 3 3 3 1 RasGEF N-terminal motif LisH PF08513.11 ELR25117.1 - 6.2e-07 29.2 1.6 8.4e-07 28.7 0.1 2.1 2 0 0 2 2 2 1 LisH DUF913 PF06025.12 ELR25117.1 - 0.0008 18.5 12.6 0.015 14.3 0.0 4.8 4 2 1 5 5 5 2 Domain of Unknown Function (DUF913) ANAPC4_WD40 PF12894.7 ELR25117.1 - 0.0052 17.1 0.0 0.019 15.3 0.0 1.9 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 ELR25117.1 - 0.0089 16.9 2.6 0.026 15.4 0.0 3.3 4 0 0 4 4 4 1 WD domain, G-beta repeat DUF3361 PF11841.8 ELR25117.1 - 0.031 14.2 0.0 0.74 9.7 0.0 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF3361) DUF4348 PF14254.6 ELR25117.1 - 0.18 11.2 0.0 0.3 10.4 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4348) Mucin PF01456.17 ELR25117.1 - 0.89 9.5 10.7 0.26 11.3 3.4 2.5 2 0 0 2 2 2 0 Mucin-like glycoprotein PAP1 PF08601.10 ELR25117.1 - 1.9 8.1 8.1 5.3 6.7 8.1 1.7 1 0 0 1 1 1 0 Transcription factor PAP1 SSP160 PF06933.11 ELR25117.1 - 3.5 5.7 11.6 5.6 5.0 11.6 1.2 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 RabGAP-TBC PF00566.18 ELR25118.1 - 6.3e-41 140.4 0.0 1.9e-40 138.9 0.0 1.8 1 0 0 1 1 1 1 Rab-GTPase-TBC domain GRAM PF02893.20 ELR25118.1 - 3.3e-11 43.1 0.1 1e-05 25.4 0.0 3.0 3 0 0 3 3 3 2 GRAM domain Pkinase PF00069.25 ELR25119.1 - 2.6e-76 256.5 0.0 1.4e-45 155.7 0.0 2.3 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ELR25119.1 - 2.9e-76 256.2 0.1 1.4e-42 145.8 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase SH2 PF00017.24 ELR25119.1 - 5.1e-07 29.7 0.0 1.2e-06 28.5 0.0 1.6 1 0 0 1 1 1 1 SH2 domain Kinase-like PF14531.6 ELR25119.1 - 1.1e-05 24.9 0.0 0.00086 18.7 0.0 2.3 2 0 0 2 2 2 2 Kinase-like IBP39 PF11422.8 ELR25119.1 - 0.022 14.6 0.0 0.046 13.5 0.0 1.5 1 0 0 1 1 1 0 Initiator binding protein 39 kDa Cbl_N2 PF02761.14 ELR25119.1 - 0.035 14.8 0.3 0.23 12.2 0.1 2.4 2 0 0 2 2 2 0 CBL proto-oncogene N-terminus, EF hand-like domain RhoGEF PF00621.20 ELR25120.1 - 5.3e-37 127.8 0.7 5.3e-37 127.8 0.7 1.6 2 0 0 2 2 2 1 RhoGEF domain IQ_SEC7_PH PF16453.5 ELR25120.1 - 8.1e-08 32.3 0.8 1.4e-07 31.6 0.1 1.7 2 0 0 2 2 2 1 PH domain Ribosomal_S21 PF01165.20 ELR25120.1 - 0.31 10.8 5.4 1.2 8.9 5.4 2.0 1 1 0 1 1 1 0 Ribosomal protein S21 PRKG1_interact PF15898.5 ELR25120.1 - 3.2 8.7 11.1 6.5 7.7 9.7 2.3 1 1 1 2 2 2 0 cGMP-dependent protein kinase interacting domain DUF4078 PF13300.6 ELR25120.1 - 8.5 6.8 10.7 3.8 7.9 5.6 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4078) TRAM_LAG1_CLN8 PF03798.16 ELR25121.1 - 3.4e-30 105.3 24.2 4.4e-30 104.9 24.2 1.1 1 0 0 1 1 1 1 TLC domain DAGAT PF03982.13 ELR25122.1 - 2e-98 329.0 0.1 6.2e-98 327.4 0.1 1.6 1 1 0 1 1 1 1 Diacylglycerol acyltransferase RhoGEF PF00621.20 ELR25123.1 - 4.1e-26 92.3 0.1 5.1e-26 92.0 0.1 1.0 1 0 0 1 1 1 1 RhoGEF domain FYVE PF01363.21 ELR25124.1 - 6.9e-06 26.1 2.3 0.0015 18.6 2.3 2.3 1 1 0 1 1 1 1 FYVE zinc finger MGC-24 PF05283.11 ELR25124.1 - 0.088 13.3 2.8 0.14 12.6 2.8 1.2 1 0 0 1 1 1 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin RFX_DNA_binding PF02257.15 ELR25125.1 - 3e-18 66.2 0.3 3.2e-17 62.9 0.0 2.2 2 0 0 2 2 2 1 RFX DNA-binding domain Pox_D5 PF03288.16 ELR25125.1 - 0.025 15.0 0.4 0.059 13.9 0.0 1.8 2 0 0 2 2 2 0 Poxvirus D5 protein-like Sec39 PF08314.11 ELR25126.1 - 1.5e-23 83.2 8.4 4.8e-10 38.6 3.8 4.3 1 1 1 2 2 2 2 Secretory pathway protein Sec39 Nbas_N PF15492.6 ELR25126.1 - 1.3e-06 28.0 0.0 4e-05 23.1 0.0 2.3 2 0 0 2 2 2 1 Neuroblastoma-amplified sequence, N terminal P22_portal PF16510.5 ELR25126.1 - 0.0046 15.6 0.0 0.0091 14.7 0.0 1.4 1 0 0 1 1 1 1 Phage P22-like portal protein FAST_1 PF06743.15 ELR25127.1 - 0.1 12.5 0.0 0.42 10.6 0.0 2.0 2 0 0 2 2 2 0 FAST kinase-like protein, subdomain 1 UQ_con PF00179.26 ELR25128.1 - 7.6e-20 71.0 0.0 8.9e-20 70.8 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme PCI PF01399.27 ELR25129.1 - 7.7e-19 68.1 1.2 1.8e-18 66.9 1.2 1.6 1 0 0 1 1 1 1 PCI domain CSN8_PSD8_EIF3K PF10075.9 ELR25129.1 - 0.035 14.1 0.1 0.093 12.7 0.1 1.8 1 0 0 1 1 1 0 CSN8/PSMD8/EIF3K family DUF1924 PF09086.11 ELR25129.1 - 0.13 12.7 0.0 0.32 11.4 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF1924) ERp29 PF07749.12 ELR25129.1 - 0.58 11.1 6.2 11 7.0 0.0 3.2 3 0 0 3 3 3 0 Endoplasmic reticulum protein ERp29, C-terminal domain SNF2_N PF00176.23 ELR25130.1 - 5e-58 196.5 1.0 1e-57 195.4 1.0 1.5 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 ELR25130.1 - 3.5e-19 69.2 0.0 1.3e-18 67.3 0.0 2.1 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Chromo PF00385.24 ELR25130.1 - 1.6e-12 47.1 0.0 5.6e-12 45.4 0.0 2.1 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain ResIII PF04851.15 ELR25130.1 - 4.7e-09 36.5 0.0 4.7e-09 36.5 0.0 4.0 4 0 0 4 4 4 1 Type III restriction enzyme, res subunit HDA2-3 PF11496.8 ELR25130.1 - 5.2e-06 25.9 0.0 5.2e-06 25.9 0.0 4.6 4 1 0 4 4 4 1 Class II histone deacetylase complex subunits 2 and 3 CHDCT2 PF08074.11 ELR25130.1 - 2.1 8.5 7.1 4.6 7.4 0.0 4.0 4 0 0 4 4 4 0 CHDCT2 (NUC038) domain DcpS_C PF11969.8 ELR25131.1 - 2.4e-05 24.8 0.0 6.7e-05 23.3 0.0 1.7 1 1 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding Pep_deformylase PF01327.21 ELR25132.1 - 5.9e-47 159.2 0.0 7.3e-47 158.9 0.0 1.0 1 0 0 1 1 1 1 Polypeptide deformylase WD40 PF00400.32 ELR25133.1 - 7.8e-25 86.7 9.3 7.8e-05 23.4 0.0 7.5 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ELR25133.1 - 4.1e-09 36.6 0.0 0.11 12.8 0.0 5.3 2 1 4 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ELR25133.1 - 2.7e-08 33.2 0.0 0.0058 15.6 0.0 3.2 2 1 1 3 3 3 3 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ELR25133.1 - 0.0051 16.7 0.1 3.6 7.4 0.1 3.5 2 1 2 4 4 4 1 Eukaryotic translation initiation factor eIF2A PD40 PF07676.12 ELR25133.1 - 0.044 13.7 0.2 19 5.3 0.0 3.2 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat Proteasome_A_N PF10584.9 ELR25133.1 - 7.7 6.3 5.5 11 5.8 0.0 3.6 5 0 0 5 5 5 0 Proteasome subunit A N-terminal signature YbaB_DNA_bd PF02575.16 ELR25134.1 - 3.7e-07 30.3 0.0 1.7e-06 28.2 0.0 1.9 2 0 0 2 2 2 1 YbaB/EbfC DNA-binding family VSG_B PF13206.6 ELR25134.1 - 0.022 14.0 0.2 0.042 13.1 0.2 1.4 2 0 0 2 2 2 0 Trypanosomal VSG domain ERCC4 PF02732.15 ELR25135.1 - 6.2e-10 39.5 0.0 1.5e-09 38.3 0.0 1.5 1 0 0 1 1 1 1 ERCC4 domain EF-hand_7 PF13499.6 ELR25136.1 - 0.00012 22.4 0.0 0.00018 21.9 0.0 1.3 1 0 0 1 1 1 1 EF-hand domain pair EF_assoc_1 PF08355.12 ELR25136.1 - 0.0049 16.4 0.1 0.0086 15.7 0.1 1.4 1 0 0 1 1 1 1 EF hand associated EF-hand_5 PF13202.6 ELR25136.1 - 0.017 14.6 0.3 0.033 13.7 0.3 1.4 1 0 0 1 1 1 0 EF hand EF-hand_8 PF13833.6 ELR25136.1 - 0.17 11.8 0.4 5.6 6.9 0.2 2.2 1 1 1 2 2 2 0 EF-hand domain pair WWE PF02825.20 ELR25137.1 - 1.4e-06 28.8 0.0 2.6e-06 27.9 0.0 1.4 1 0 0 1 1 1 1 WWE domain BSP_II PF05432.11 ELR25137.1 - 0.021 14.5 11.6 0.027 14.2 11.6 1.1 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) TFIIF_alpha PF05793.12 ELR25137.1 - 0.63 8.6 21.1 0.83 8.2 21.1 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Raftlin PF15250.6 ELR25137.1 - 1.1 7.9 6.9 1.4 7.6 6.9 1.1 1 0 0 1 1 1 0 Raftlin Pep1_7 PF17232.2 ELR25137.1 - 4.1 7.9 11.1 4.3 7.9 2.5 2.3 2 0 0 2 2 2 0 Elicitor peptide 1-7 SAPS PF04499.15 ELR25137.1 - 7.2 5.3 6.6 7.9 5.1 6.6 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein zf-C3HC4_3 PF13920.6 ELR25138.1 - 3.1e-09 36.5 7.8 4.4e-09 36.1 7.8 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 ELR25138.1 - 5.2e-09 36.3 11.4 7.2e-09 35.8 11.4 1.2 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 ELR25138.1 - 1.4e-08 34.5 11.0 2e-08 34.0 11.0 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 ELR25138.1 - 3.5e-08 33.2 10.6 4.9e-08 32.7 10.6 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 ELR25138.1 - 2.5e-07 30.9 7.2 3.8e-07 30.3 7.2 1.3 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_UBOX PF13445.6 ELR25138.1 - 3.8e-07 30.0 4.9 5.2e-07 29.6 3.8 1.7 1 1 0 2 2 2 1 RING-type zinc-finger Prok-RING_4 PF14447.6 ELR25138.1 - 3.4e-06 26.8 8.0 5e-06 26.3 8.0 1.2 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 ELR25138.1 - 5e-06 26.4 8.2 8.4e-06 25.7 8.2 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_4 PF15227.6 ELR25138.1 - 0.0005 20.2 7.8 0.0016 18.5 7.8 1.9 1 1 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-ANAPC11 PF12861.7 ELR25138.1 - 0.0042 17.1 4.5 0.0081 16.2 4.5 1.4 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_10 PF16685.5 ELR25138.1 - 0.1 12.7 3.9 0.17 12.0 3.9 1.3 1 0 0 1 1 1 0 zinc RING finger of MSL2 zf-P11 PF03854.14 ELR25138.1 - 0.35 10.6 4.7 0.58 9.9 4.7 1.3 1 0 0 1 1 1 0 P-11 zinc finger zf-RING_11 PF17123.5 ELR25138.1 - 1.1 9.1 9.7 3 7.7 9.7 1.8 1 1 0 1 1 1 0 RING-like zinc finger zf-RING_4 PF14570.6 ELR25138.1 - 1.4 8.8 8.4 3.6 7.5 8.4 1.7 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain tRNA_anti-codon PF01336.25 ELR25139.1 - 0.12 12.4 0.0 0.22 11.5 0.0 1.4 1 0 0 1 1 1 0 OB-fold nucleic acid binding domain Serpin PF00079.20 ELR25140.1 - 6.9e-70 236.2 0.0 8.9e-70 235.8 0.0 1.1 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) DUF3827 PF12877.7 ELR25141.1 - 0.0057 15.1 0.9 0.009 14.5 0.9 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3827) DUF4448 PF14610.6 ELR25141.1 - 0.046 13.5 0.2 0.1 12.4 0.2 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF4448) Med20 PF08612.11 ELR25142.1 - 8.4e-23 80.9 0.0 6.9e-22 77.9 0.0 1.9 1 1 0 1 1 1 1 TATA-binding related factor (TRF) of subunit 20 of Mediator complex Elf1 PF05129.13 ELR25143.1 - 1.4e-31 108.4 4.4 1.5e-31 108.2 4.4 1.0 1 0 0 1 1 1 1 Transcription elongation factor Elf1 like zf-AN1 PF01428.16 ELR25143.1 - 0.059 13.6 2.9 3.6 7.8 0.2 2.3 2 0 0 2 2 2 0 AN1-like Zinc finger Ribosomal_L37ae PF01780.19 ELR25143.1 - 0.063 13.4 1.5 0.11 12.6 1.5 1.4 1 1 0 1 1 1 0 Ribosomal L37ae protein family Rubredoxin PF00301.20 ELR25143.1 - 0.15 12.1 4.3 0.22 11.6 0.1 2.5 3 0 0 3 3 3 0 Rubredoxin Lar_restr_allev PF14354.6 ELR25143.1 - 0.15 12.4 3.6 0.21 12.0 3.6 1.4 1 1 0 1 1 1 0 Restriction alleviation protein Lar zf-Sec23_Sec24 PF04810.15 ELR25143.1 - 0.26 11.4 5.5 0.98 9.5 0.4 2.5 1 1 1 2 2 2 0 Sec23/Sec24 zinc finger NDUFA12 PF05071.16 ELR25144.1 - 8.6e-23 81.0 4.6 1.1e-22 80.6 4.6 1.2 1 0 0 1 1 1 1 NADH ubiquinone oxidoreductase subunit NDUFA12 DUF2157 PF09925.9 ELR25147.1 - 2 8.2 10.3 0.076 12.8 3.5 2.2 2 0 0 2 2 2 0 Predicted membrane protein (DUF2157) PAF-AH_p_II PF03403.13 ELR25148.1 - 4.8e-33 114.2 0.0 2e-32 112.2 0.0 1.8 1 1 0 1 1 1 1 Platelet-activating factor acetylhydrolase, isoform II Chlorophyllase2 PF12740.7 ELR25148.1 - 6.1e-10 38.4 0.0 1.5e-09 37.2 0.0 1.6 1 1 0 1 1 1 1 Chlorophyllase enzyme Chlorophyllase PF07224.11 ELR25148.1 - 0.00043 19.4 0.1 0.41 9.6 0.0 2.3 2 0 0 2 2 2 2 Chlorophyllase Hydrolase_4 PF12146.8 ELR25148.1 - 0.0051 16.1 0.0 1.9 7.7 0.0 2.3 2 0 0 2 2 2 2 Serine aminopeptidase, S33 DLH PF01738.18 ELR25148.1 - 0.027 14.0 0.0 0.064 12.8 0.0 1.7 1 1 0 1 1 1 0 Dienelactone hydrolase family OATP PF03137.20 ELR25148.1 - 0.057 11.7 0.0 0.079 11.2 0.0 1.1 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family Adeno_PX PF05829.12 ELR25148.1 - 0.11 12.3 0.7 0.36 10.7 0.7 1.8 1 0 0 1 1 1 0 Adenovirus late L2 mu core protein (Protein X) BRCT PF00533.26 ELR25149.1 - 8.2e-05 22.9 0.0 0.0011 19.3 0.0 2.4 2 0 0 2 2 2 1 BRCA1 C Terminus (BRCT) domain RTT107_BRCT_5 PF16770.5 ELR25149.1 - 0.0054 16.6 0.0 0.018 14.9 0.0 1.9 1 0 0 1 1 1 1 Regulator of Ty1 transposition protein 107 BRCT domain BRCT_2 PF16589.5 ELR25149.1 - 0.008 16.6 0.0 2.6 8.5 0.0 2.6 2 0 0 2 2 2 2 BRCT domain, a BRCA1 C-terminus domain DUF4597 PF15366.6 ELR25149.1 - 2.8 7.8 5.7 59 3.5 0.4 3.7 3 0 0 3 3 3 0 Domain of unknown function (DUF4597) WD40 PF00400.32 ELR25150.1 - 0.00019 22.1 0.1 9.2 7.3 0.0 4.3 4 0 0 4 4 4 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ELR25150.1 - 0.00083 19.6 0.0 0.067 13.5 0.0 3.1 3 0 0 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain Hamartin PF04388.12 ELR25150.1 - 0.11 11.2 7.3 0.17 10.5 7.3 1.2 1 0 0 1 1 1 0 Hamartin protein NAM-associated PF14303.6 ELR25150.1 - 0.16 12.7 13.6 0.29 11.8 13.6 1.3 1 0 0 1 1 1 0 No apical meristem-associated C-terminal domain CDC27 PF09507.10 ELR25150.1 - 0.23 10.8 13.5 0.42 10.0 13.5 1.3 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 CCSAP PF15748.5 ELR25150.1 - 0.26 11.4 16.5 0.52 10.4 16.5 1.4 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated DUF908 PF06012.12 ELR25150.1 - 1.4 8.3 8.7 6.6 6.0 9.7 1.7 2 0 0 2 2 2 0 Domain of Unknown Function (DUF908) Pacs-1 PF10254.9 ELR25150.1 - 1.9 7.4 6.7 2.6 6.9 6.7 1.1 1 0 0 1 1 1 0 PACS-1 cytosolic sorting protein Macoilin PF09726.9 ELR25150.1 - 5.2 5.5 11.5 7.8 4.9 11.5 1.2 1 0 0 1 1 1 0 Macoilin family SOBP PF15279.6 ELR25150.1 - 6 7.4 10.2 12 6.4 10.2 1.4 1 0 0 1 1 1 0 Sine oculis-binding protein Aldose_epim PF01263.20 ELR25151.1 - 1e-22 80.9 0.0 1.4e-22 80.4 0.0 1.1 1 0 0 1 1 1 1 Aldose 1-epimerase Esterase_phd PF10503.9 ELR25152.1 - 3.3e-51 173.9 4.0 2.8e-50 170.9 1.2 2.2 2 0 0 2 2 2 2 Esterase PHB depolymerase Peptidase_S9 PF00326.21 ELR25152.1 - 4.5e-06 26.3 0.4 8e-06 25.5 0.4 1.4 1 0 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_2 PF02230.16 ELR25152.1 - 0.0001 22.2 0.0 0.0014 18.5 0.0 2.1 2 0 0 2 2 2 1 Phospholipase/Carboxylesterase Esterase PF00756.20 ELR25152.1 - 0.0033 17.1 0.6 0.0058 16.3 0.6 1.3 1 0 0 1 1 1 1 Putative esterase ECH_1 PF00378.20 ELR25153.1 - 3.7e-51 173.9 0.0 4.2e-51 173.7 0.0 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 ELR25153.1 - 1.7e-30 106.6 0.0 3.2e-26 92.6 0.0 2.0 1 1 1 2 2 2 2 Enoyl-CoA hydratase/isomerase DUF4537 PF15057.6 ELR25154.1 - 0.084 12.9 0.0 0.2 11.7 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4537) Bactofilin PF04519.13 ELR25154.1 - 0.18 12.1 6.2 1.2 9.5 0.1 4.1 4 1 0 4 4 4 0 Polymer-forming cytoskeletal DUF5597 PF18120.1 ELR25154.1 - 1 9.4 10.1 18 5.5 0.0 5.6 4 2 1 5 5 5 0 Domain of unknown function (DUF5597) IBR PF01485.21 ELR25155.1 - 0.068 13.4 0.4 0.17 12.2 0.4 1.6 1 0 0 1 1 1 0 IBR domain, a half RING-finger domain LRR_6 PF13516.6 ELR25156.1 - 2.1e-18 64.8 38.6 8.7e-06 25.4 0.0 11.6 12 0 0 12 12 12 6 Leucine Rich repeat LRR_4 PF12799.7 ELR25156.1 - 0.00029 21.1 31.9 0.33 11.4 0.5 7.7 6 2 4 10 10 10 7 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 ELR25156.1 - 0.0018 18.6 8.5 29 5.7 0.1 7.6 10 1 0 10 10 10 1 Leucine Rich Repeat LRR_8 PF13855.6 ELR25156.1 - 2.3 8.0 24.2 1.9 8.3 0.1 7.3 5 3 1 6 6 6 0 Leucine rich repeat HhH-GPD PF00730.25 ELR25157.1 - 6.6e-09 36.2 0.0 1e-08 35.6 0.0 1.4 1 1 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein EBV-NA3 PF05009.12 ELR25157.1 - 0.042 13.4 2.9 0.073 12.6 2.9 1.3 1 0 0 1 1 1 0 Epstein-Barr virus nuclear antigen 3 (EBNA-3) PGA2 PF07543.12 ELR25157.1 - 0.55 10.2 11.9 3.1 7.8 13.1 1.6 2 0 0 2 2 2 0 Protein trafficking PGA2 PBP1_TM PF14812.6 ELR25157.1 - 3.1 8.2 11.1 2.4 8.6 9.2 1.8 1 1 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Cmc1 PF08583.10 ELR25158.1 - 3.3e-12 46.2 2.3 3.7e-12 46.1 2.3 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase biogenesis protein Cmc1 like NDUF_B7 PF05676.13 ELR25158.1 - 0.0023 17.6 0.9 0.0032 17.1 0.9 1.2 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) Mrpl_C PF18502.1 ELR25158.1 - 0.05 13.9 0.0 0.055 13.8 0.0 1.1 1 0 0 1 1 1 0 54S ribosomal protein L8 C-terminal domain WD40 PF00400.32 ELR25159.1 - 1.5e-37 127.0 29.4 4.4e-06 27.3 0.1 9.1 8 2 1 9 9 9 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ELR25159.1 - 7.2e-22 77.5 0.9 1.8e-05 24.9 0.0 6.2 3 2 3 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain LisH PF08513.11 ELR25159.1 - 2.1e-09 37.0 0.2 4e-09 36.1 0.2 1.5 1 0 0 1 1 1 1 LisH eIF2A PF08662.11 ELR25159.1 - 2.3e-06 27.6 1.0 0.00098 19.0 0.1 3.3 3 1 1 4 4 4 2 Eukaryotic translation initiation factor eIF2A Coatomer_WDAD PF04053.14 ELR25159.1 - 0.034 13.2 0.1 0.22 10.5 0.0 2.2 3 0 0 3 3 3 0 Coatomer WD associated region Myotub-related PF06602.14 ELR25160.1 - 4.9e-61 206.6 0.0 7.2e-61 206.1 0.0 1.2 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain Pkinase_Tyr PF07714.17 ELR25160.1 - 8e-47 159.7 0.0 1.4e-46 158.9 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase COR PF16095.5 ELR25160.1 - 1.2e-41 142.7 0.0 2.1e-41 141.9 0.0 1.4 1 0 0 1 1 1 1 C-terminal of Roc, COR, domain Pkinase PF00069.25 ELR25160.1 - 1.3e-39 136.2 0.0 2.5e-39 135.2 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain LRR_8 PF13855.6 ELR25160.1 - 3.1e-32 110.1 27.4 1.3e-10 40.9 0.4 6.2 4 1 1 5 5 5 5 Leucine rich repeat LRR_4 PF12799.7 ELR25160.1 - 1.1e-26 92.4 22.2 1.7e-05 25.1 0.0 7.4 4 1 3 8 8 8 7 Leucine Rich repeats (2 copies) Roc PF08477.13 ELR25160.1 - 3.7e-21 75.6 0.0 3.1e-19 69.4 0.0 2.8 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase PH PF00169.29 ELR25160.1 - 5.4e-14 52.6 0.0 1.6e-13 51.1 0.0 1.8 1 0 0 1 1 1 1 PH domain LRR_1 PF00560.33 ELR25160.1 - 8.9e-08 31.7 23.1 2.4 9.0 0.2 10.5 11 0 0 11 11 10 1 Leucine Rich Repeat Ras PF00071.22 ELR25160.1 - 5e-07 29.5 0.0 9.9e-05 22.0 0.0 2.3 2 0 0 2 2 2 1 Ras family LRR_9 PF14580.6 ELR25160.1 - 1.6e-06 27.7 1.3 0.04 13.4 0.3 2.7 2 0 0 2 2 2 2 Leucine-rich repeat PH_8 PF15409.6 ELR25160.1 - 3.9e-06 27.1 0.0 1.6e-05 25.1 0.0 2.1 2 0 0 2 2 2 1 Pleckstrin homology domain LRR_6 PF13516.6 ELR25160.1 - 0.0014 18.5 35.8 3.7 7.8 0.0 10.4 11 0 0 11 11 10 2 Leucine Rich repeat MMR_HSR1 PF01926.23 ELR25160.1 - 0.0056 16.8 0.0 0.012 15.6 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase TniB PF05621.11 ELR25160.1 - 0.0063 15.9 0.0 0.042 13.3 0.0 2.1 2 0 0 2 2 2 1 Bacterial TniB protein Ndufs5 PF10200.9 ELR25160.1 - 0.0082 16.4 0.1 0.028 14.7 0.1 1.8 1 0 0 1 1 1 1 NADH:ubiquinone oxidoreductase, NDUFS5-15kDa PH_9 PF15410.6 ELR25160.1 - 0.017 15.4 0.0 0.05 14.0 0.0 1.7 1 0 0 1 1 1 0 Pleckstrin homology domain PduV-EutP PF10662.9 ELR25160.1 - 0.057 13.2 0.1 0.13 12.0 0.1 1.5 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation ABC_tran PF00005.27 ELR25160.1 - 0.087 13.3 0.0 0.21 12.1 0.0 1.6 1 0 0 1 1 1 0 ABC transporter PH_6 PF15406.6 ELR25160.1 - 0.094 13.0 0.0 0.22 11.8 0.0 1.6 1 0 0 1 1 1 0 Pleckstrin homology domain Arf PF00025.21 ELR25160.1 - 0.24 10.8 0.6 1.1 8.7 0.0 2.4 3 0 0 3 3 3 0 ADP-ribosylation factor family DUF4281 PF14108.6 ELR25161.1 - 3.1e-09 37.3 5.5 5.3e-09 36.5 5.5 1.4 1 1 0 1 1 1 1 Domain of unknown function (DUF4281) Yip1 PF04893.17 ELR25161.1 - 2.4 7.9 13.3 0.57 9.9 5.7 2.0 1 1 1 2 2 2 0 Yip1 domain PH PF00169.29 ELR25162.1 - 8.2e-09 35.9 0.8 2.5e-08 34.4 0.0 2.2 2 1 0 2 2 2 1 PH domain RICTOR_N PF14664.6 ELR25162.1 - 0.48 9.4 0.0 0.48 9.4 0.0 1.8 2 0 0 2 2 2 0 Rapamycin-insensitive companion of mTOR, N-term GREB1 PF15782.5 ELR25162.1 - 3.4 4.6 28.4 0.21 8.6 5.1 2.1 2 0 0 2 2 2 0 Gene regulated by oestrogen in breast cancer SapB_2 PF03489.17 ELR25163.1 - 1e-12 47.9 7.4 2.7e-06 27.4 2.3 2.8 2 0 0 2 2 2 2 Saposin-like type B, region 2 SapB_1 PF05184.15 ELR25163.1 - 2.7e-07 30.5 10.1 3.9e-06 26.8 2.9 2.9 3 0 0 3 3 3 2 Saposin-like type B, region 1 DNA_pol_A PF00476.20 ELR25164.1 - 8e-110 367.4 0.0 1.3e-109 366.7 0.0 1.3 1 0 0 1 1 1 1 DNA polymerase family A DNA_pol_P_Exo PF18049.1 ELR25164.1 - 0.029 13.8 0.0 0.06 12.7 0.0 1.5 1 0 0 1 1 1 0 DNA polymerase nu pseudo-exo Rubis-subs-bind PF09273.11 ELR25165.1 - 5.2e-09 36.9 0.9 1e-08 35.9 0.9 1.5 1 0 0 1 1 1 1 Rubisco LSMT substrate-binding SET PF00856.28 ELR25165.1 - 1.6e-08 35.1 0.0 2e-06 28.3 0.0 2.6 2 1 0 2 2 2 1 SET domain DUF4632 PF15451.6 ELR25165.1 - 0.014 15.4 2.2 0.052 13.6 1.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4632) adh_short_C2 PF13561.6 ELR25166.1 - 4.4e-52 177.0 0.9 5.5e-52 176.6 0.9 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 ELR25166.1 - 5.1e-45 153.3 0.2 7.2e-45 152.9 0.2 1.2 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 ELR25166.1 - 4.9e-10 39.6 0.2 7.4e-10 39.0 0.2 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 ELR25166.1 - 0.0013 18.3 0.2 0.0018 17.7 0.2 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NmrA PF05368.13 ELR25166.1 - 0.011 15.3 1.0 0.019 14.6 1.0 1.4 1 0 0 1 1 1 0 NmrA-like family ADH_zinc_N PF00107.26 ELR25166.1 - 0.015 15.2 1.1 0.19 11.7 1.1 2.4 1 1 0 1 1 1 0 Zinc-binding dehydrogenase DUF4170 PF13773.6 ELR25166.1 - 0.095 12.9 0.0 0.19 11.9 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4170) Pkinase PF00069.25 ELR25167.1 - 2.6e-63 213.9 0.0 3.4e-63 213.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR25167.1 - 2.2e-37 128.7 0.0 3.2e-37 128.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 ELR25167.1 - 7.4e-05 22.8 1.6 0.00037 20.5 0.1 2.6 2 1 1 3 3 3 1 Phosphotransferase enzyme family Kinase-like PF14531.6 ELR25167.1 - 0.0008 18.8 0.0 0.0029 17.0 0.0 1.8 2 0 0 2 2 2 1 Kinase-like Choline_kinase PF01633.20 ELR25167.1 - 0.053 13.1 0.0 0.093 12.3 0.0 1.3 1 0 0 1 1 1 0 Choline/ethanolamine kinase Haspin_kinase PF12330.8 ELR25167.1 - 0.14 11.1 0.0 0.2 10.5 0.0 1.2 1 0 0 1 1 1 0 Haspin like kinase domain KA1 PF02149.19 ELR25167.1 - 0.16 11.8 0.0 0.33 10.8 0.0 1.5 1 0 0 1 1 1 0 Kinase associated domain 1 SET PF00856.28 ELR25169.1 - 0.011 16.1 0.0 0.051 14.0 0.0 2.1 2 1 0 2 2 2 0 SET domain DUF2939 PF11159.8 ELR25169.1 - 0.029 14.8 0.4 0.2 12.1 0.0 2.6 2 1 1 3 3 3 0 Protein of unknown function (DUF2939) PRT_C PF08372.10 ELR25169.1 - 0.12 12.1 0.6 0.23 11.2 0.6 1.3 1 0 0 1 1 1 0 Plant phosphoribosyltransferase C-terminal TPR_2 PF07719.17 ELR25169.1 - 0.13 12.4 4.3 5.4 7.4 0.2 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_12 PF13424.6 ELR25169.1 - 0.27 11.5 7.7 2.7 8.3 1.1 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat eIF3_subunit PF08597.10 ELR25169.1 - 0.65 9.9 4.3 1.2 9.0 4.3 1.3 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit Ribosomal_S8e PF01201.22 ELR25170.1 - 5.5e-56 188.5 1.4 6.8e-56 188.2 1.4 1.1 1 0 0 1 1 1 1 Ribosomal protein S8e DUF1631 PF07793.11 ELR25170.1 - 0.049 12.1 1.3 0.057 11.9 1.3 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1631) Cas9-BH PF16593.5 ELR25170.1 - 0.11 12.3 0.3 0.11 12.3 0.3 2.0 2 0 0 2 2 2 0 Bridge helix of CRISPR-associated endonuclease Cas9 DUF3597 PF12200.8 ELR25170.1 - 0.63 10.6 5.4 1.5 9.4 5.4 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF3597) DUF3987 PF13148.6 ELR25170.1 - 9.6 5.1 10.4 14 4.5 10.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3987) Npa1 PF11707.8 ELR25171.1 - 8e-44 150.4 0.0 1.6e-43 149.4 0.0 1.5 1 0 0 1 1 1 1 Ribosome 60S biogenesis N-terminal NopRA1 PF16201.5 ELR25171.1 - 3e-40 138.0 0.3 1.3e-38 132.6 0.0 2.7 2 0 0 2 2 2 1 Nucleolar pre-ribosomal-associated protein 1 Creb_binding PF09030.10 ELR25171.1 - 0.0011 19.6 0.2 0.0011 19.6 0.2 3.2 4 0 0 4 4 4 1 Creb binding FliE PF02049.18 ELR25171.1 - 0.087 13.0 0.0 11 6.2 0.0 3.1 2 0 0 2 2 2 0 Flagellar hook-basal body complex protein FliE Nucleoporin_FG PF13634.6 ELR25171.1 - 2.5 9.0 6.7 12 6.9 2.8 2.6 2 0 0 2 2 2 0 Nucleoporin FG repeat region DNA_pol_B PF00136.21 ELR25172.1 - 3.6e-145 484.2 0.0 4.8e-145 483.8 0.0 1.2 1 0 0 1 1 1 1 DNA polymerase family B DNA_pol_B_exo1 PF03104.19 ELR25172.1 - 1.1e-75 254.9 0.0 1.7e-75 254.3 0.0 1.3 1 0 0 1 1 1 1 DNA polymerase family B, exonuclease domain zf-C4pol PF14260.6 ELR25172.1 - 4.3e-16 59.1 8.3 9.6e-16 58.0 8.3 1.6 1 0 0 1 1 1 1 C4-type zinc-finger of DNA polymerase delta DNA_pol_B_2 PF03175.13 ELR25172.1 - 0.015 14.2 0.1 0.028 13.3 0.1 1.4 1 0 0 1 1 1 0 DNA polymerase type B, organellar and viral Pkinase PF00069.25 ELR25173.1 - 1.6e-50 171.9 0.0 5.5e-35 121.0 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ELR25173.1 - 1.1e-13 51.1 0.0 7.2e-06 25.5 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Prp19 PF08606.11 ELR25174.1 - 6.5e-32 109.3 2.0 1.2e-31 108.4 2.0 1.5 1 0 0 1 1 1 1 Prp19/Pso4-like WD40 PF00400.32 ELR25174.1 - 3.9e-29 100.3 12.8 7e-09 36.2 0.1 7.4 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ELR25174.1 - 5.3e-11 42.7 0.0 0.0099 16.2 0.0 5.2 1 1 5 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain zf-Nse PF11789.8 ELR25174.1 - 1.6e-06 27.8 0.0 2.7e-06 27.1 0.0 1.4 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit Ge1_WD40 PF16529.5 ELR25174.1 - 2e-05 23.8 0.1 0.072 12.0 0.0 3.6 2 1 2 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ELR25174.1 - 0.0041 15.8 0.2 0.31 9.6 0.1 2.6 2 1 1 3 3 3 1 Nucleoporin Nup120/160 U-box PF04564.15 ELR25174.1 - 0.019 15.1 0.0 0.047 13.9 0.0 1.6 1 0 0 1 1 1 0 U-box domain V_ATPase_I_N PF18670.1 ELR25174.1 - 0.027 14.8 0.4 0.074 13.5 0.4 1.7 1 0 0 1 1 1 0 V-type ATPase subunit I, N-terminal domain Rtf2 PF04641.12 ELR25174.1 - 0.05 13.0 0.2 0.58 9.5 0.0 2.0 2 0 0 2 2 2 0 Rtf2 RING-finger RasGEF PF00617.19 ELR25175.1 - 1.4e-42 145.9 0.1 3.7e-42 144.5 0.1 1.8 1 0 0 1 1 1 1 RasGEF domain Kelch_3 PF13415.6 ELR25175.1 - 8.8e-24 83.3 2.1 1.2e-06 28.6 0.0 4.5 4 0 0 4 4 4 4 Galactose oxidase, central domain RasGEF_N PF00618.20 ELR25175.1 - 1.4e-22 80.0 0.0 3.8e-22 78.5 0.0 1.8 1 0 0 1 1 1 1 RasGEF N-terminal motif Kelch_4 PF13418.6 ELR25175.1 - 2.1e-21 75.7 6.4 1.9e-06 27.7 0.0 4.4 3 1 1 4 4 4 4 Galactose oxidase, central domain Kelch_1 PF01344.25 ELR25175.1 - 3.2e-20 71.4 5.8 1.1e-06 28.1 0.1 4.4 4 0 0 4 4 4 4 Kelch motif Kelch_5 PF13854.6 ELR25175.1 - 6e-19 67.6 2.2 1.1e-05 25.3 0.1 4.5 4 0 0 4 4 4 4 Kelch motif Kelch_6 PF13964.6 ELR25175.1 - 2.6e-16 59.2 2.6 1.7e-05 24.9 0.1 4.5 4 0 0 4 4 4 4 Kelch motif Kelch_2 PF07646.15 ELR25175.1 - 3.5e-11 42.6 7.3 0.0075 16.2 0.1 4.8 5 0 0 5 5 5 3 Kelch motif ADSL_C PF10397.9 ELR25175.1 - 0.25 11.9 2.0 43 4.7 0.1 3.9 3 0 0 3 3 3 0 Adenylosuccinate lyase C-terminus Kelch_4 PF13418.6 ELR25176.1 - 2.3e-06 27.5 0.4 7.2e-06 25.9 0.4 1.9 1 0 0 1 1 1 1 Galactose oxidase, central domain Kelch_5 PF13854.6 ELR25176.1 - 1.5e-05 24.8 0.0 3.1e-05 23.8 0.0 1.6 1 0 0 1 1 1 1 Kelch motif Kelch_6 PF13964.6 ELR25176.1 - 0.065 13.6 0.0 0.23 11.8 0.0 2.0 1 0 0 1 1 1 0 Kelch motif Ank_2 PF12796.7 ELR25177.1 - 4.9e-16 59.1 0.2 1.8e-06 28.4 0.0 3.2 3 0 0 3 3 3 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 ELR25177.1 - 1.5e-15 55.8 0.3 0.003 17.9 0.0 4.9 5 0 0 5 5 5 3 Ankyrin repeat Ank_4 PF13637.6 ELR25177.1 - 1.4e-10 41.4 0.6 5.2e-06 26.9 0.0 3.6 2 1 2 4 4 4 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 ELR25177.1 - 9.2e-10 38.6 2.4 0.0029 17.9 0.0 4.5 3 1 1 4 4 4 2 Ankyrin repeats (many copies) Ank PF00023.30 ELR25177.1 - 7.1e-08 32.6 8.6 0.003 18.0 0.0 4.7 6 0 0 6 6 6 3 Ankyrin repeat Phosphoprotein PF00922.17 ELR25177.1 - 0.75 9.4 0.0 0.75 9.4 0.0 2.7 3 0 0 3 3 3 0 Vesiculovirus phosphoprotein DUF1415 PF07209.12 ELR25178.1 - 2.3e-34 118.6 0.1 2.9e-34 118.3 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1415) HlyIII PF03006.20 ELR25179.1 - 5.5e-50 170.2 23.2 7.5e-50 169.7 23.2 1.1 1 0 0 1 1 1 1 Haemolysin-III related Ham1p_like PF01725.16 ELR25180.1 - 1.9e-21 76.8 0.0 2.5e-21 76.5 0.0 1.1 1 0 0 1 1 1 1 Ham1 family F-box-like PF12937.7 ELR25181.1 - 1.7e-08 34.2 0.1 3.1e-08 33.4 0.1 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ELR25181.1 - 0.028 14.3 0.0 0.054 13.4 0.0 1.4 1 0 0 1 1 1 0 F-box domain Pkinase PF00069.25 ELR25182.1 - 2.4e-75 253.3 0.2 8.9e-75 251.4 0.0 2.1 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR25182.1 - 4.3e-55 186.8 0.0 1.1e-54 185.4 0.0 1.7 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ELR25182.1 - 4.4e-05 22.9 4.4 8.3e-05 22.0 0.0 2.9 3 0 0 3 3 3 1 Kinase-like APH PF01636.23 ELR25182.1 - 0.095 12.6 0.1 1 9.2 0.0 2.6 2 1 0 2 2 2 0 Phosphotransferase enzyme family ApbA_C PF08546.11 ELR25183.1 - 0.038 14.2 0.8 0.65 10.2 0.0 2.3 2 0 0 2 2 2 0 Ketopantoate reductase PanE/ApbA C terminal LpqV PF17301.2 ELR25183.1 - 0.35 11.1 5.2 0.17 12.1 1.8 2.2 2 0 0 2 2 2 0 Putative lipoprotein LpqV DUF3040 PF11239.8 ELR25183.1 - 0.9 9.9 6.6 3.5 8.0 3.2 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF3040) DivIC PF04977.15 ELR25183.1 - 1.6 8.6 10.0 4.3 7.2 0.2 2.7 2 1 1 3 3 3 0 Septum formation initiator MORN PF02493.20 ELR25184.1 - 2.6e-38 127.7 45.4 1e-06 28.2 0.1 9.7 10 0 0 10 10 10 8 MORN repeat DUF3048_C PF17479.2 ELR25184.1 - 0.029 14.7 9.8 11 6.5 0.7 4.4 3 1 2 5 5 5 0 Protein of unknown function (DUF3048) C-terminal domain EamA PF00892.20 ELR25185.1 - 9.4e-08 32.3 13.3 1.1e-07 32.1 13.3 1.1 1 0 0 1 1 1 1 EamA-like transporter family Sugar_transport PF06800.12 ELR25185.1 - 1.3e-06 28.0 5.6 1.6e-06 27.6 5.6 1.1 1 0 0 1 1 1 1 Sugar transport protein EMC3_TMCO1 PF01956.16 ELR25185.1 - 0.16 11.7 0.7 0.23 11.2 0.3 1.6 1 1 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like Cytochrom_B558a PF05038.13 ELR25185.1 - 0.19 11.3 1.3 0.44 10.1 1.3 1.5 1 0 0 1 1 1 0 Cytochrome Cytochrome b558 alpha-subunit RasGAP PF00616.19 ELR25186.1 - 8.5e-13 48.5 0.0 1.1e-12 48.1 0.0 1.1 1 0 0 1 1 1 1 GTPase-activator protein for Ras-like GTPase AAA PF00004.29 ELR25188.1 - 4e-19 69.4 0.0 1e-18 68.0 0.0 1.7 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) BCS1_N PF08740.11 ELR25188.1 - 2.7e-07 30.7 0.0 5.6e-07 29.7 0.0 1.5 1 0 0 1 1 1 1 BCS1 N terminal AAA_16 PF13191.6 ELR25188.1 - 2e-05 25.0 0.0 0.00033 21.1 0.0 2.2 2 0 0 2 2 2 1 AAA ATPase domain RNA_helicase PF00910.22 ELR25188.1 - 0.00019 21.8 0.0 0.017 15.5 0.0 2.7 3 0 0 3 3 3 1 RNA helicase AAA_25 PF13481.6 ELR25188.1 - 0.00089 18.9 0.0 0.0022 17.6 0.0 1.7 1 1 0 1 1 1 1 AAA domain PPV_E1_C PF00519.17 ELR25188.1 - 0.0014 17.6 0.0 0.0024 16.8 0.0 1.3 1 0 0 1 1 1 1 Papillomavirus helicase AAA_7 PF12775.7 ELR25188.1 - 0.0045 16.5 0.0 0.0081 15.7 0.0 1.3 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_11 PF13086.6 ELR25188.1 - 0.0074 16.1 0.0 0.015 15.1 0.0 1.4 2 0 0 2 2 2 1 AAA domain AAA_5 PF07728.14 ELR25188.1 - 0.0095 15.9 0.0 0.016 15.2 0.0 1.5 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_29 PF13555.6 ELR25188.1 - 0.011 15.4 0.0 0.031 14.0 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain IstB_IS21 PF01695.17 ELR25188.1 - 0.017 14.8 0.0 0.043 13.6 0.0 1.6 1 0 0 1 1 1 0 IstB-like ATP binding protein DUF815 PF05673.13 ELR25188.1 - 0.034 13.3 0.0 0.052 12.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_24 PF13479.6 ELR25188.1 - 0.036 13.8 0.0 0.074 12.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 ELR25188.1 - 0.07 13.3 0.0 0.13 12.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain RuvB_N PF05496.12 ELR25188.1 - 0.079 12.7 0.0 0.14 11.9 0.0 1.3 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 ELR25188.1 - 0.08 13.2 0.0 0.19 12.0 0.0 1.7 1 0 0 1 1 1 0 AAA domain MMR_HSR1 PF01926.23 ELR25188.1 - 0.087 12.9 0.0 0.21 11.7 0.0 1.7 1 0 0 1 1 1 0 50S ribosome-binding GTPase FeS_assembly_P PF01883.19 ELR25188.1 - 0.089 13.0 0.0 0.2 11.8 0.0 1.5 1 0 0 1 1 1 0 Iron-sulfur cluster assembly protein ABC_tran PF00005.27 ELR25188.1 - 0.09 13.3 0.0 0.3 11.6 0.0 1.8 2 0 0 2 2 2 0 ABC transporter ATPase PF06745.13 ELR25188.1 - 0.094 12.1 0.0 0.19 11.0 0.0 1.4 1 0 0 1 1 1 0 KaiC RsgA_GTPase PF03193.16 ELR25188.1 - 0.097 12.6 0.0 0.22 11.4 0.0 1.5 1 0 0 1 1 1 0 RsgA GTPase YodL PF14191.6 ELR25189.1 - 0.13 13.1 0.0 0.28 12.0 0.0 1.5 1 0 0 1 1 1 0 YodL-like RasGAP PF00616.19 ELR25190.1 - 1.1e-24 87.3 0.0 1.7e-24 86.7 0.0 1.3 1 0 0 1 1 1 1 GTPase-activator protein for Ras-like GTPase Laminin_G_3 PF13385.6 ELR25190.1 - 3.6e-10 40.2 0.2 1.2e-08 35.3 0.3 3.1 2 1 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily RasGAP PF00616.19 ELR25191.1 - 3.3e-14 53.1 0.0 5.6e-14 52.3 0.0 1.4 1 0 0 1 1 1 1 GTPase-activator protein for Ras-like GTPase Herpes_gE PF02480.16 ELR25191.1 - 0.16 10.7 0.0 0.3 9.8 0.0 1.4 1 0 0 1 1 1 0 Alphaherpesvirus glycoprotein E Gly-zipper_Omp PF13488.6 ELR25191.1 - 0.47 10.5 6.4 1.1 9.3 6.4 1.5 1 0 0 1 1 1 0 Glycine zipper Laminin_G_3 PF13385.6 ELR25192.1 - 5e-11 43.0 1.7 1.2e-08 35.2 0.0 2.7 2 1 1 3 3 3 2 Concanavalin A-like lectin/glucanases superfamily RasGAP PF00616.19 ELR25193.1 - 9.6e-05 22.2 0.0 0.00014 21.7 0.0 1.2 1 0 0 1 1 1 1 GTPase-activator protein for Ras-like GTPase TspO_MBR PF03073.15 ELR25193.1 - 0.16 12.1 1.2 6.9 6.7 0.5 2.3 1 1 0 2 2 2 0 TspO/MBR family Gly-zipper_Omp PF13488.6 ELR25193.1 - 0.2 11.7 8.6 0.36 10.8 8.6 1.4 1 0 0 1 1 1 0 Glycine zipper RasGAP PF00616.19 ELR25194.1 - 3.4e-13 49.8 0.1 5.6e-13 49.1 0.1 1.4 1 1 0 1 1 1 1 GTPase-activator protein for Ras-like GTPase RasGEF PF00617.19 ELR25195.1 - 8.4e-46 156.4 0.2 1.8e-45 155.3 0.2 1.6 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 ELR25195.1 - 4.7e-20 71.8 0.0 1.2e-19 70.4 0.0 1.7 1 0 0 1 1 1 1 RasGEF N-terminal motif EamA PF00892.20 ELR25196.1 - 1.5e-22 80.3 28.4 2.1e-20 73.3 18.1 2.0 2 0 0 2 2 2 2 EamA-like transporter family DUF2070 PF09843.9 ELR25196.1 - 0.94 7.7 7.6 1.2 7.4 7.6 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) TMEM234 PF10639.9 ELR25196.1 - 3 7.9 10.5 1.9 8.6 0.4 3.1 2 1 1 3 3 3 0 Putative transmembrane family 234 DUF5362 PF17319.2 ELR25196.1 - 5.3 7.0 9.8 1.8 8.5 0.1 3.9 4 1 0 4 4 4 0 Family of unknown function (DUF5362) RhoGEF PF00621.20 ELR25197.1 - 4.3e-36 124.8 6.4 4.3e-36 124.8 6.4 1.7 2 0 0 2 2 2 1 RhoGEF domain Rad60-SLD_2 PF13881.6 ELR25197.1 - 0.011 15.9 0.0 0.032 14.3 0.0 1.8 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like PKcGMP_CC PF16808.5 ELR25197.1 - 0.015 15.1 0.0 0.037 13.9 0.0 1.7 1 0 0 1 1 1 0 Coiled-coil N-terminus of cGMP-dependent protein kinase Csm1_N PF18504.1 ELR25197.1 - 0.17 12.2 4.9 0.9 9.9 0.1 3.2 2 0 0 2 2 2 0 Csm1 N-terminal domain SelR PF01641.18 ELR25198.1 - 3.5e-53 178.8 0.1 4e-53 178.6 0.1 1.0 1 0 0 1 1 1 1 SelR domain Zn_ribbon_SprT PF17283.2 ELR25198.1 - 0.0011 18.8 0.0 0.004 17.0 0.0 1.9 1 1 0 1 1 1 1 SprT-like zinc ribbon domain zinc_ribbon_10 PF10058.9 ELR25198.1 - 0.002 17.8 0.0 0.12 12.1 0.0 2.2 2 0 0 2 2 2 1 Predicted integral membrane zinc-ribbon metal-binding protein DZR PF12773.7 ELR25198.1 - 0.047 13.7 1.7 1.7 8.8 0.1 2.3 2 1 0 2 2 2 0 Double zinc ribbon Yippee-Mis18 PF03226.14 ELR25198.1 - 0.064 13.5 0.3 0.19 11.9 0.3 1.8 1 1 0 1 1 1 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly MCM_OB PF17207.3 ELR25198.1 - 0.12 12.3 0.0 0.23 11.3 0.0 1.4 1 0 0 1 1 1 0 MCM OB domain Myb_DNA-bind_6 PF13921.6 ELR25199.1 - 8.6e-09 35.5 6.7 1.6e-07 31.5 0.4 2.8 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-binding PF00249.31 ELR25199.1 - 1e-07 32.0 10.1 1.1e-07 31.9 1.2 2.9 3 0 0 3 3 3 2 Myb-like DNA-binding domain Myb_DNA-bind_4 PF13837.6 ELR25199.1 - 0.00073 19.9 6.5 0.0022 18.3 1.0 2.9 1 1 0 2 2 2 1 Myb/SANT-like DNA-binding domain SANT_DAMP1_like PF16282.5 ELR25199.1 - 1.3 9.3 6.9 8.6 6.6 0.1 2.4 1 1 1 2 2 2 0 SANT/Myb-like domain of DAMP1 U-box PF04564.15 ELR25200.1 - 4.1e-13 49.3 0.0 6.9e-13 48.6 0.0 1.4 1 0 0 1 1 1 1 U-box domain zf-Nse PF11789.8 ELR25200.1 - 4e-08 33.0 0.1 1.3e-07 31.4 0.1 1.9 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-C3HC4_2 PF13923.6 ELR25200.1 - 8.7e-06 25.5 0.1 8.7e-06 25.5 0.1 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 ELR25200.1 - 9.1e-06 25.9 0.1 9.1e-06 25.9 0.1 2.3 2 0 0 2 2 2 1 RING-H2 zinc finger domain zf-RING_2 PF13639.6 ELR25200.1 - 3.3e-05 24.1 0.1 3.3e-05 24.1 0.1 2.7 2 0 0 2 2 2 1 Ring finger domain zf-RING_UBOX PF13445.6 ELR25200.1 - 3.5e-05 23.7 0.0 0.012 15.6 0.0 2.8 2 0 0 2 2 2 1 RING-type zinc-finger Rtf2 PF04641.12 ELR25200.1 - 0.032 13.6 0.0 0.042 13.2 0.0 1.2 1 0 0 1 1 1 0 Rtf2 RING-finger Rad50_zn_hook PF04423.14 ELR25200.1 - 0.034 14.0 0.0 0.1 12.4 0.0 1.8 1 0 0 1 1 1 0 Rad50 zinc hook motif Insulin_TMD PF17870.1 ELR25200.1 - 0.098 12.7 0.3 0.19 11.9 0.2 1.5 1 1 0 1 1 1 0 Insulin receptor trans-membrane segment U-box PF04564.15 ELR25201.1 - 5.5e-14 52.1 0.0 1e-13 51.2 0.0 1.4 1 0 0 1 1 1 1 U-box domain zf-Nse PF11789.8 ELR25201.1 - 5.3e-08 32.6 0.5 2e-07 30.7 0.5 2.0 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-rbx1 PF12678.7 ELR25201.1 - 2.3e-05 24.6 1.3 2.3e-05 24.6 1.3 2.5 3 0 0 3 3 3 1 RING-H2 zinc finger domain zf-C3HC4_2 PF13923.6 ELR25201.1 - 3.6e-05 23.5 4.5 4e-05 23.4 2.0 2.5 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 ELR25201.1 - 0.00013 22.2 1.1 0.00013 22.2 1.1 2.8 3 0 0 3 3 3 1 Ring finger domain zf-RING_UBOX PF13445.6 ELR25201.1 - 0.00019 21.4 2.8 0.0071 16.3 0.1 3.1 3 0 0 3 3 3 1 RING-type zinc-finger zf-C3HC4 PF00097.25 ELR25201.1 - 0.0051 16.6 0.9 0.0051 16.6 0.9 2.5 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 ELR25201.1 - 0.0082 16.2 0.9 0.02 14.9 0.9 1.7 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger Rtf2 PF04641.12 ELR25201.1 - 0.15 11.4 0.0 0.21 10.9 0.0 1.3 1 0 0 1 1 1 0 Rtf2 RING-finger Lysyl_oxidase PF01186.17 ELR25202.1 - 7.5e-41 140.0 0.0 1.5e-40 139.0 0.0 1.5 1 0 0 1 1 1 1 Lysyl oxidase Laminin_G_3 PF13385.6 ELR25202.1 - 5.1e-21 75.4 0.0 9.8e-21 74.5 0.0 1.5 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily DnaJ PF00226.31 ELR25203.1 - 2.4e-17 62.8 0.0 3.2e-17 62.4 0.0 1.2 1 0 0 1 1 1 1 DnaJ domain Cadherin_C_2 PF16492.5 ELR25203.1 - 0.039 14.7 0.2 0.071 13.9 0.2 1.4 1 0 0 1 1 1 0 Cadherin cytoplasmic C-terminal Glyco_trans_4_3 PF12000.8 ELR25204.1 - 0.048 13.3 0.8 0.086 12.5 0.8 1.4 1 0 0 1 1 1 0 Glycosyl transferase family 4 group Npa1 PF11707.8 ELR25205.1 - 1.3e-23 84.0 0.0 1.8e-23 83.5 0.0 1.1 1 0 0 1 1 1 1 Ribosome 60S biogenesis N-terminal Creb_binding PF09030.10 ELR25205.1 - 0.0001 23.0 0.2 0.00019 22.1 0.2 1.4 1 0 0 1 1 1 1 Creb binding MutH PF02976.15 ELR25206.1 - 0.032 14.3 0.1 4.1 7.5 0.0 2.3 2 0 0 2 2 2 0 DNA mismatch repair enzyme MutH Pim PF16765.5 ELR25206.1 - 0.062 13.5 0.0 0.12 12.6 0.0 1.4 1 0 0 1 1 1 0 Pesticin immunity protein Ctr PF04145.15 ELR25208.1 - 3.2e-29 102.5 0.2 4.8e-29 101.9 0.2 1.3 1 0 0 1 1 1 1 Ctr copper transporter family Arm PF00514.23 ELR25211.1 - 2.3e-07 30.6 6.6 0.14 12.2 0.1 4.7 4 1 0 4 4 4 4 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.6 ELR25212.1 - 0.021 15.2 0.5 2.1 8.8 0.0 3.8 2 2 2 4 4 4 0 HEAT repeats Churchill PF06573.11 ELR25213.1 - 6e-45 152.1 8.4 6.7e-45 152.0 8.4 1.0 1 0 0 1 1 1 1 Churchill protein zf-CSL PF05207.13 ELR25213.1 - 0.076 12.7 5.5 1 9.1 1.8 2.4 2 0 0 2 2 2 0 CSL zinc finger Terminase_GpA PF05876.12 ELR25213.1 - 0.11 11.0 1.3 0.13 10.8 1.3 1.1 1 0 0 1 1 1 0 Phage terminase large subunit (GpA) DUF2072 PF09845.9 ELR25213.1 - 0.73 10.1 8.4 0.96 9.7 6.3 1.9 1 1 1 2 2 2 0 Zn-ribbon containing protein Cupin_8 PF13621.6 ELR25215.1 - 1.3e-43 149.5 0.0 1.7e-43 149.2 0.0 1.1 1 0 0 1 1 1 1 Cupin-like domain Cupin_4 PF08007.12 ELR25215.1 - 1.8e-09 37.5 1.4 2.5e-09 37.0 0.7 1.6 2 0 0 2 2 2 1 Cupin superfamily protein Cupin_2 PF07883.11 ELR25215.1 - 0.0013 18.4 0.2 0.015 15.0 0.0 2.7 3 1 1 4 4 4 1 Cupin domain JmjC PF02373.22 ELR25215.1 - 0.014 15.8 0.0 0.034 14.6 0.0 1.8 1 1 0 1 1 1 0 JmjC domain, hydroxylase ParA PF10609.9 ELR25216.1 - 2.1e-91 305.8 0.3 2.3e-91 305.6 0.3 1.0 1 0 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase CbiA PF01656.23 ELR25216.1 - 1.5e-11 44.4 0.0 3.1e-11 43.4 0.0 1.6 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_31 PF13614.6 ELR25216.1 - 1.2e-09 38.4 1.6 1.4e-08 34.9 1.6 2.0 1 1 0 1 1 1 1 AAA domain MipZ PF09140.11 ELR25216.1 - 3.7e-08 33.0 0.1 1.3e-07 31.2 0.1 1.8 1 1 0 1 1 1 1 ATPase MipZ ArsA_ATPase PF02374.15 ELR25216.1 - 6.8e-07 28.8 3.4 1.2e-06 27.9 1.0 2.2 2 1 1 3 3 3 1 Anion-transporting ATPase MeaB PF03308.16 ELR25216.1 - 3.1e-05 23.1 0.2 4.5e-05 22.6 0.2 1.1 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB Fer4_NifH PF00142.18 ELR25216.1 - 0.00018 21.1 0.1 0.00028 20.4 0.1 1.3 1 0 0 1 1 1 1 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family CBP_BcsQ PF06564.12 ELR25216.1 - 0.00026 20.6 0.0 0.00068 19.2 0.0 1.6 2 0 0 2 2 2 1 Cellulose biosynthesis protein BcsQ AAA_25 PF13481.6 ELR25216.1 - 0.00074 19.2 0.1 0.0013 18.4 0.1 1.4 1 0 0 1 1 1 1 AAA domain CLP1_P PF16575.5 ELR25216.1 - 0.003 17.4 0.2 0.0068 16.2 0.1 1.6 2 0 0 2 2 2 1 mRNA cleavage and polyadenylation factor CLP1 P-loop SRP54 PF00448.22 ELR25216.1 - 0.0076 15.9 0.3 0.018 14.7 0.4 1.5 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain APS_kinase PF01583.20 ELR25216.1 - 0.0088 15.9 0.1 0.013 15.4 0.1 1.2 1 0 0 1 1 1 1 Adenylylsulphate kinase RsgA_GTPase PF03193.16 ELR25216.1 - 0.015 15.2 0.3 0.033 14.1 0.3 1.5 1 0 0 1 1 1 0 RsgA GTPase NB-ARC PF00931.22 ELR25216.1 - 0.018 14.3 0.2 0.03 13.5 0.2 1.3 1 0 0 1 1 1 0 NB-ARC domain AAA_16 PF13191.6 ELR25216.1 - 0.027 14.9 0.0 0.034 14.5 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain IstB_IS21 PF01695.17 ELR25216.1 - 0.038 13.7 0.2 0.067 12.9 0.2 1.3 1 0 0 1 1 1 0 IstB-like ATP binding protein VirC1 PF07015.11 ELR25216.1 - 0.058 12.7 0.1 0.088 12.1 0.1 1.2 1 0 0 1 1 1 0 VirC1 protein Zeta_toxin PF06414.12 ELR25216.1 - 0.072 12.4 0.0 0.1 11.8 0.0 1.2 1 0 0 1 1 1 0 Zeta toxin PhoH PF02562.16 ELR25216.1 - 0.079 12.4 0.1 0.11 11.9 0.1 1.3 1 0 0 1 1 1 0 PhoH-like protein Rad17 PF03215.15 ELR25216.1 - 0.082 12.8 0.2 0.16 11.8 0.2 1.4 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_22 PF13401.6 ELR25216.1 - 0.11 12.7 0.1 0.4 11.0 0.1 1.8 2 0 0 2 2 2 0 AAA domain Zn_Tnp_IS1595 PF12760.7 ELR25216.1 - 0.12 12.4 0.6 5 7.2 0.3 2.3 2 0 0 2 2 2 0 Transposase zinc-ribbon domain AAA_30 PF13604.6 ELR25216.1 - 0.13 12.0 0.2 0.22 11.2 0.2 1.3 1 0 0 1 1 1 0 AAA domain AAA_26 PF13500.6 ELR25216.1 - 0.13 12.1 1.4 3.4 7.4 1.0 2.1 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 ELR25216.1 - 0.14 12.6 0.1 0.23 11.8 0.1 1.4 1 0 0 1 1 1 0 RNA helicase KTI12 PF08433.10 ELR25216.1 - 0.16 11.4 0.1 0.21 11.0 0.1 1.1 1 0 0 1 1 1 0 Chromatin associated protein KTI12 NTPase_1 PF03266.15 ELR25216.1 - 1.1 9.2 3.0 1.2 9.0 0.9 1.9 2 0 0 2 2 2 0 NTPase UPF0172 PF03665.13 ELR25217.1 - 1e-40 139.8 4.5 2e-39 135.6 4.5 2.0 1 1 0 1 1 1 1 Uncharacterised protein family (UPF0172) zf-U1 PF06220.12 ELR25219.1 - 6.5e-22 77.0 3.8 1.3e-21 76.1 3.8 1.5 1 0 0 1 1 1 1 U1 zinc finger CLIP1_ZNF PF16641.5 ELR25219.1 - 0.11 12.4 2.9 0.19 11.6 2.9 1.4 1 0 0 1 1 1 0 CLIP1 zinc knuckle CLU PF13236.6 ELR25220.1 - 2.3e-57 194.4 0.0 4.6e-57 193.4 0.0 1.5 1 0 0 1 1 1 1 Clustered mitochondria TPR_17 PF13431.6 ELR25220.1 - 8.1e-08 32.1 2.0 0.00073 19.7 0.2 3.7 3 0 0 3 3 3 2 Tetratricopeptide repeat eIF3_p135 PF12807.7 ELR25220.1 - 1.5e-05 25.1 0.1 3e-05 24.1 0.1 1.5 1 0 0 1 1 1 1 Translation initiation factor eIF3 subunit 135 TPR_19 PF14559.6 ELR25220.1 - 0.0028 18.1 0.8 0.075 13.6 0.3 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.6 ELR25220.1 - 0.0033 18.1 0.0 0.041 14.7 0.0 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_2 PF07719.17 ELR25220.1 - 0.0036 17.3 3.0 0.15 12.2 0.1 3.9 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_1 PF00515.28 ELR25220.1 - 0.0062 16.3 1.9 0.046 13.6 0.1 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_8 PF13181.6 ELR25220.1 - 0.024 14.8 3.2 0.04 14.1 0.1 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat ANAPC3 PF12895.7 ELR25220.1 - 0.19 12.0 2.5 0.21 11.8 1.0 1.9 2 0 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 RhoGAP PF00620.27 ELR25221.1 - 7.1e-30 103.8 0.0 1.1e-29 103.2 0.0 1.2 1 0 0 1 1 1 1 RhoGAP domain DUF4736 PF15883.5 ELR25221.1 - 0.079 12.7 0.7 0.27 11.0 0.3 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4736) RhoGAP PF00620.27 ELR25222.1 - 4.3e-38 130.5 0.0 8.3e-38 129.6 0.0 1.4 1 0 0 1 1 1 1 RhoGAP domain AhpC-TSA PF00578.21 ELR25222.1 - 3.1e-34 117.6 0.0 1.5e-33 115.4 0.0 2.0 2 0 0 2 2 2 1 AhpC/TSA family Redoxin PF08534.10 ELR25222.1 - 8e-17 61.3 0.0 1.5e-16 60.5 0.0 1.4 1 0 0 1 1 1 1 Redoxin C1_1 PF00130.22 ELR25222.1 - 4.3e-06 26.5 6.0 7.7e-06 25.7 6.0 1.4 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) C1_2 PF03107.16 ELR25222.1 - 0.0078 16.5 3.7 0.017 15.4 3.7 1.6 1 0 0 1 1 1 1 C1 domain LSM14 PF12701.7 ELR25223.1 - 2.9e-34 117.0 0.0 4.8e-34 116.3 0.0 1.4 1 0 0 1 1 1 1 Scd6-like Sm domain FDF PF09532.10 ELR25223.1 - 5.6e-12 46.5 0.9 5.6e-12 46.5 0.9 2.3 2 0 0 2 2 2 1 FDF domain SM-ATX PF14438.6 ELR25223.1 - 2.6e-09 37.1 0.0 4.9e-09 36.2 0.0 1.4 1 0 0 1 1 1 1 Ataxin 2 SM domain LSM PF01423.22 ELR25223.1 - 0.22 11.2 0.0 0.35 10.6 0.0 1.3 1 0 0 1 1 1 0 LSM domain PTPRCAP PF15713.5 ELR25223.1 - 0.93 9.8 8.7 2.1 8.6 8.7 1.5 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated Phosphodiest PF01663.22 ELR25224.1 - 1.4e-75 255.1 0.1 1.7e-75 254.9 0.1 1.1 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.23 ELR25224.1 - 2.1e-06 27.4 0.3 0.0045 16.4 0.3 3.0 1 1 0 1 1 1 1 Sulfatase Metalloenzyme PF01676.18 ELR25224.1 - 0.055 12.8 0.0 0.11 11.8 0.0 1.4 1 1 0 1 1 1 0 Metalloenzyme superfamily DUF5345 PF17280.2 ELR25224.1 - 0.058 13.4 0.6 0.11 12.4 0.6 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5345) PglZ PF08665.12 ELR25224.1 - 0.17 12.0 0.0 0.38 10.8 0.0 1.5 1 0 0 1 1 1 0 PglZ domain Methyltransf_32 PF13679.6 ELR25226.1 - 4.4e-09 36.5 0.2 4.5e-07 30.0 0.2 2.4 1 1 0 1 1 1 1 Methyltransferase domain PBP1_TM PF14812.6 ELR25226.1 - 0.095 13.1 5.9 0.25 11.7 5.9 1.7 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal RPA43_OB PF17875.1 ELR25226.1 - 0.17 12.5 6.1 3.6 8.2 0.2 2.8 3 0 0 3 3 3 0 RPA43 OB domain in RNA Pol I SART-1 PF03343.13 ELR25226.1 - 0.43 9.1 12.3 0.68 8.4 12.3 1.2 1 0 0 1 1 1 0 SART-1 family DUF1682 PF07946.14 ELR25226.1 - 2.5 7.3 5.0 3.5 6.8 5.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) DnaJ PF00226.31 ELR25227.1 - 4e-18 65.3 0.6 4e-18 65.3 0.6 1.8 2 0 0 2 2 2 1 DnaJ domain DUF4460 PF14687.6 ELR25227.1 - 0.085 12.9 0.6 0.23 11.5 0.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4460) PIG-S PF10510.9 ELR25227.1 - 0.41 9.4 3.4 0.59 8.9 3.4 1.1 1 0 0 1 1 1 0 Phosphatidylinositol-glycan biosynthesis class S protein SBF2 PF12335.8 ELR25227.1 - 0.55 9.8 6.5 0.87 9.2 6.5 1.2 1 0 0 1 1 1 0 Myotubularin protein CDC45 PF02724.14 ELR25228.1 - 2e-155 518.7 4.5 2.5e-155 518.4 4.5 1.1 1 0 0 1 1 1 1 CDC45-like protein YL1 PF05764.13 ELR25228.1 - 0.0035 17.5 8.1 0.0035 17.5 8.1 1.9 2 0 0 2 2 2 1 YL1 nuclear protein DNA_pol_D_N PF18018.1 ELR25229.1 - 8e-43 145.7 0.0 1.4e-42 144.9 0.0 1.4 1 0 0 1 1 1 1 DNA polymerase delta subunit OB-fold domain DNA_pol_E_B PF04042.16 ELR25229.1 - 3.9e-39 134.2 0.0 1.9e-38 131.9 0.0 2.1 2 0 0 2 2 2 1 DNA polymerase alpha/epsilon subunit B WD40 PF00400.32 ELR25230.1 - 2.1e-10 41.0 0.5 0.006 17.4 0.0 5.3 5 0 0 5 5 5 2 WD domain, G-beta repeat eIF2A PF08662.11 ELR25230.1 - 1.2e-05 25.3 0.0 0.39 10.6 0.0 3.5 2 1 1 3 3 3 3 Eukaryotic translation initiation factor eIF2A ANAPC4_WD40 PF12894.7 ELR25230.1 - 5.6e-05 23.4 0.0 0.12 12.7 0.0 3.3 1 1 3 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain DUF2267 PF10025.9 ELR25232.1 - 8.8e-22 77.7 0.0 1.1e-21 77.4 0.0 1.1 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2267) FRB_dom PF08771.11 ELR25232.1 - 0.013 15.9 0.0 0.03 14.7 0.0 1.6 2 0 0 2 2 2 0 FKBP12-rapamycin binding domain Ras PF00071.22 ELR25233.1 - 1.4e-54 184.0 0.0 1.7e-54 183.8 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR25233.1 - 1.3e-21 77.0 0.0 2.2e-21 76.3 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR25233.1 - 1.4e-09 37.6 0.0 1.7e-09 37.4 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 ELR25233.1 - 0.00035 20.2 0.1 0.00058 19.5 0.1 1.4 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 ELR25233.1 - 0.00059 19.8 0.0 0.99 9.3 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase TIR_2 PF13676.6 ELR25233.1 - 0.13 12.9 0.0 0.23 12.1 0.0 1.6 1 0 0 1 1 1 0 TIR domain AAA_22 PF13401.6 ELR25233.1 - 0.15 12.3 0.2 4 7.7 0.1 2.6 1 1 1 2 2 2 0 AAA domain SWI2_SNF2 PF18766.1 ELR25234.1 - 1.1e-29 103.7 0.1 2.4e-29 102.6 0.1 1.5 1 0 0 1 1 1 1 SWI2/SNF2 ATPase ResIII PF04851.15 ELR25234.1 - 2.3e-15 57.0 0.1 2.3e-15 57.0 0.1 2.0 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Arm PF00514.23 ELR25234.1 - 1.3e-11 44.1 4.1 0.00014 21.8 0.1 5.4 5 0 0 5 5 5 2 Armadillo/beta-catenin-like repeat DEAD PF00270.29 ELR25234.1 - 4.4e-08 33.1 0.0 8.1e-08 32.2 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Atx10homo_assoc PF09759.9 ELR25234.1 - 9e-07 28.8 0.0 3.2e-06 27.1 0.0 1.9 1 0 0 1 1 1 1 Spinocerebellar ataxia type 10 protein domain V-ATPase_H_N PF03224.14 ELR25234.1 - 0.04 13.2 1.4 5.6 6.2 0.0 3.3 3 0 0 3 3 3 0 V-ATPase subunit H FAM167 PF11652.8 ELR25234.1 - 1.1 9.8 0.0 1.1 9.8 0.0 3.1 4 0 0 4 4 4 0 FAM167 Nop53 PF07767.11 ELR25234.1 - 1.6 8.0 20.0 4.1 6.7 20.0 1.6 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) Cupin_5 PF06172.11 ELR25236.1 - 2.9e-48 163.6 0.0 3.2e-48 163.5 0.0 1.0 1 0 0 1 1 1 1 Cupin superfamily (DUF985) Ras PF00071.22 ELR25237.1 - 1.6e-62 209.9 0.1 1.9e-62 209.6 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR25237.1 - 1.9e-35 121.6 0.1 2.8e-35 121.1 0.1 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR25237.1 - 6e-12 45.4 0.1 7.3e-12 45.1 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 ELR25237.1 - 1.6e-07 31.4 0.1 2.9e-07 30.6 0.1 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 ELR25237.1 - 1.9e-05 24.6 0.1 0.014 15.3 0.0 2.1 2 0 0 2 2 2 2 RsgA GTPase AAA_22 PF13401.6 ELR25237.1 - 0.00032 21.0 0.1 0.0026 18.1 0.1 2.3 2 1 0 2 2 2 1 AAA domain GTP_EFTU PF00009.27 ELR25237.1 - 0.00035 20.2 0.1 0.0014 18.2 0.1 1.8 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain FeoB_N PF02421.18 ELR25237.1 - 0.0027 17.3 0.1 0.0071 15.9 0.1 1.6 1 1 0 1 1 1 1 Ferrous iron transport protein B Gtr1_RagA PF04670.12 ELR25237.1 - 0.0045 16.4 0.0 0.0067 15.8 0.0 1.4 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region AAA_16 PF13191.6 ELR25237.1 - 0.0056 17.1 0.1 0.0094 16.3 0.1 1.6 1 1 0 1 1 1 1 AAA ATPase domain SRPRB PF09439.10 ELR25237.1 - 0.012 15.1 0.0 0.021 14.3 0.0 1.5 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit TniB PF05621.11 ELR25237.1 - 0.019 14.4 0.0 0.055 12.9 0.0 1.8 1 1 0 1 1 1 0 Bacterial TniB protein ABC_tran PF00005.27 ELR25237.1 - 0.029 14.9 0.1 0.045 14.3 0.1 1.5 1 1 0 1 1 1 0 ABC transporter AAA_14 PF13173.6 ELR25237.1 - 0.032 14.3 0.1 0.081 13.0 0.1 1.7 1 1 0 1 1 1 0 AAA domain AAA_21 PF13304.6 ELR25237.1 - 0.034 14.0 0.6 0.15 11.9 0.3 2.0 1 1 1 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system FAD-SLDH PF12318.8 ELR25237.1 - 0.034 14.2 0.0 0.059 13.4 0.0 1.4 1 0 0 1 1 1 0 Membrane bound FAD containing D-sorbitol dehydrogenase MCM PF00493.23 ELR25237.1 - 0.042 12.9 0.1 0.15 11.1 0.0 2.0 2 1 0 2 2 2 0 MCM P-loop domain AAA_24 PF13479.6 ELR25237.1 - 0.059 13.1 0.0 0.11 12.2 0.0 1.6 1 1 0 1 1 1 0 AAA domain PduV-EutP PF10662.9 ELR25237.1 - 0.096 12.4 0.0 0.2 11.4 0.0 1.7 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation AAA_7 PF12775.7 ELR25237.1 - 0.11 12.0 0.0 0.18 11.3 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_5 PF07728.14 ELR25237.1 - 0.13 12.3 0.0 0.26 11.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) MORN PF02493.20 ELR25238.1 - 2.3e-39 130.9 41.8 1.1e-07 31.3 1.0 6.3 6 0 0 6 6 6 6 MORN repeat DUF3048_C PF17479.2 ELR25238.1 - 0.0066 16.8 16.7 1.1 9.7 0.9 3.8 1 1 3 4 4 4 4 Protein of unknown function (DUF3048) C-terminal domain DUF523 PF04463.12 ELR25238.1 - 0.75 9.8 3.2 7.8 6.5 0.1 3.3 1 1 3 4 4 4 0 Protein of unknown function (DUF523) OTCace_N PF02729.21 ELR25239.1 - 1.8e-44 151.3 0.0 3.8e-44 150.3 0.0 1.5 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain OTCace PF00185.24 ELR25239.1 - 3.7e-30 105.1 0.0 5.8e-30 104.5 0.0 1.3 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain Calpain_III PF01067.22 ELR25239.1 - 0.12 12.6 0.0 0.6 10.4 0.0 1.9 2 0 0 2 2 2 0 Calpain large subunit, domain III YccF PF03733.13 ELR25240.1 - 6.2e-22 78.1 26.2 6.5e-12 46.0 9.4 2.2 2 0 0 2 2 2 2 Inner membrane component domain Promethin PF16015.5 ELR25240.1 - 3.7e-06 26.8 12.8 9.8e-06 25.4 1.3 2.2 2 0 0 2 2 2 2 Promethin DUF1286 PF06939.11 ELR25240.1 - 0.017 15.4 0.1 0.29 11.4 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1286) TRIQK PF15168.6 ELR25240.1 - 0.12 12.2 4.4 1 9.3 0.7 2.5 2 0 0 2 2 2 0 Triple QxxK/R motif-containing protein family RhoGEF PF00621.20 ELR25241.1 - 8.2e-49 166.3 5.2 1.4e-48 165.5 5.2 1.4 1 0 0 1 1 1 1 RhoGEF domain PH_13 PF16652.5 ELR25241.1 - 0.017 14.9 0.0 3 7.7 0.0 3.0 2 0 0 2 2 2 0 Pleckstrin homology domain Ribosomal_S7e PF01251.18 ELR25241.1 - 0.025 14.3 1.2 0.061 13.1 1.2 1.6 1 0 0 1 1 1 0 Ribosomal protein S7e LapA_dom PF06305.11 ELR25242.1 - 0.0026 17.6 1.1 0.0032 17.2 0.9 1.4 1 1 0 1 1 1 1 Lipopolysaccharide assembly protein A domain Uds1 PF15456.6 ELR25242.1 - 0.0039 17.4 0.5 0.0046 17.1 0.5 1.1 1 0 0 1 1 1 1 Up-regulated During Septation DUF1043 PF06295.12 ELR25242.1 - 0.013 15.4 1.3 0.016 15.2 1.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1043) DUF2868 PF11067.8 ELR25242.1 - 0.015 14.8 0.5 0.016 14.8 0.5 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2868) HemX PF04375.14 ELR25242.1 - 0.016 14.5 0.7 0.017 14.4 0.7 1.0 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase DUF2681 PF10883.8 ELR25242.1 - 0.026 14.9 1.7 0.031 14.7 1.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2681) DUF3365 PF11845.8 ELR25242.1 - 0.076 13.3 0.0 0.083 13.2 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3365) Flp_Fap PF04964.14 ELR25242.1 - 0.082 12.7 0.1 0.13 12.2 0.1 1.4 1 0 0 1 1 1 0 Flp/Fap pilin component DASH_Hsk3 PF08227.11 ELR25242.1 - 0.13 12.6 4.8 0.19 12.1 4.8 1.2 1 0 0 1 1 1 0 DASH complex subunit Hsk3 like WW_1 PF18507.1 ELR25242.1 - 0.39 10.4 0.2 0.39 10.4 0.2 1.8 2 0 0 2 2 2 0 WW domain FHA PF00498.26 ELR25243.1 - 9.6e-11 41.9 0.0 1.8e-10 41.0 0.0 1.4 1 0 0 1 1 1 1 FHA domain NIBRIN_BRCT_II PF16508.5 ELR25243.1 - 2.3e-08 34.4 0.0 1.5e-07 31.8 0.0 2.5 2 1 0 2 2 2 1 Second BRCT domain on Nijmegen syndrome breakage protein Yop-YscD_cpl PF16697.5 ELR25243.1 - 0.00083 19.6 0.0 0.0059 16.9 0.0 2.4 1 1 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain Nbs1_C PF08599.10 ELR25243.1 - 0.0013 18.9 1.7 0.0013 18.9 1.7 2.9 2 1 0 2 2 2 1 DNA damage repair protein Nbs1 NIF PF03031.18 ELR25244.1 - 6.6e-28 97.4 0.0 1.5e-27 96.3 0.0 1.5 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase PTCB-BRCT PF12738.7 ELR25244.1 - 3.7e-08 33.2 0.0 6.6e-08 32.4 0.0 1.4 1 0 0 1 1 1 1 twin BRCT domain BRCT PF00533.26 ELR25244.1 - 3.7e-06 27.2 0.0 6.8e-06 26.4 0.0 1.5 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain LIG3_BRCT PF16759.5 ELR25244.1 - 0.014 15.6 0.0 0.032 14.5 0.0 1.5 1 0 0 1 1 1 0 DNA ligase 3 BRCT domain FAM199X PF15814.5 ELR25244.1 - 0.054 12.6 5.9 0.083 11.9 2.5 2.2 2 0 0 2 2 2 0 Protein family FAM199X FAM104 PF15434.6 ELR25244.1 - 0.14 12.8 9.6 3.1 8.4 0.0 3.0 2 0 0 2 2 2 0 Family 104 SOG2 PF10428.9 ELR25244.1 - 1.9 7.6 18.4 3.7 6.6 18.4 1.4 1 0 0 1 1 1 0 RAM signalling pathway protein PARM PF17061.5 ELR25244.1 - 2.9 8.0 33.4 5.8 7.0 33.4 1.4 1 0 0 1 1 1 0 PARM Vpu PF00558.19 ELR25245.1 - 0.0036 17.0 3.0 0.013 15.2 3.0 2.0 1 0 0 1 1 1 1 Vpu protein Caudo_TAP PF02413.17 ELR25245.1 - 0.99 9.6 11.2 0.67 10.1 3.6 2.2 2 0 0 2 2 2 0 Caudovirales tail fibre assembly protein, lambda gpK FAM176 PF14851.6 ELR25245.1 - 6.8 6.3 12.1 3.6 7.2 2.7 2.5 2 0 0 2 2 2 0 FAM176 family Kri1_C PF12936.7 ELR25246.1 - 1.1e-24 86.4 0.5 1.1e-24 86.4 0.5 4.6 3 2 1 4 4 4 1 KRI1-like family C-terminal Kri1 PF05178.12 ELR25246.1 - 3.5e-19 69.3 9.9 3.5e-19 69.3 9.9 4.9 3 2 2 5 5 5 1 KRI1-like family DUF936 PF06075.12 ELR25246.1 - 0.068 12.1 24.7 0.0098 14.9 14.6 2.1 2 0 0 2 2 2 0 Plant protein of unknown function (DUF936) Dsh_C PF12316.8 ELR25246.1 - 9.9 6.5 17.6 1.1 9.7 10.8 2.2 2 0 0 2 2 2 0 Segment polarity protein dishevelled (Dsh) C terminal Pkinase PF00069.25 ELR25247.1 - 2.3e-94 315.7 0.0 1.1e-39 136.5 0.0 4.8 3 1 0 3 3 3 3 Protein kinase domain Pkinase_Tyr PF07714.17 ELR25247.1 - 5.2e-49 166.9 0.3 3.2e-18 66.0 0.0 6.3 5 1 0 5 5 5 3 Protein tyrosine kinase tRNA-synt_His PF13393.6 ELR25247.1 - 2.6e-24 86.1 0.0 3.5e-13 49.5 0.0 2.5 2 0 0 2 2 2 2 Histidyl-tRNA synthetase RWD PF05773.22 ELR25247.1 - 4.7e-19 68.8 0.1 2e-18 66.8 0.0 2.2 2 0 0 2 2 2 1 RWD domain Kinase-like PF14531.6 ELR25247.1 - 1.9e-07 30.7 0.1 0.013 14.8 0.0 2.5 2 0 0 2 2 2 2 Kinase-like Seadorna_VP7 PF07387.11 ELR25247.1 - 1e-06 28.0 0.2 0.0016 17.6 0.1 2.4 2 0 0 2 2 2 2 Seadornavirus VP7 HGTP_anticodon2 PF12745.7 ELR25247.1 - 1.7e-06 27.7 11.8 4.3e-06 26.4 0.0 3.5 4 0 0 4 4 4 2 Anticodon binding domain of tRNAs Kdo PF06293.14 ELR25247.1 - 3e-06 26.8 3.1 0.0086 15.5 0.0 3.0 3 0 0 3 3 3 2 Lipopolysaccharide kinase (Kdo/WaaP) family HGTP_anticodon PF03129.20 ELR25247.1 - 7.4e-05 22.8 0.2 0.3 11.2 0.0 3.6 3 0 0 3 3 3 1 Anticodon binding domain APH PF01636.23 ELR25247.1 - 0.00053 20.0 0.2 0.1 12.5 0.0 2.8 2 0 0 2 2 2 1 Phosphotransferase enzyme family FTA2 PF13095.6 ELR25247.1 - 0.033 13.8 0.2 13 5.3 0.0 3.3 3 0 0 3 3 3 0 Kinetochore Sim4 complex subunit FTA2 RSN1_7TM PF02714.15 ELR25248.1 - 2.7e-65 220.4 18.2 5.2e-65 219.5 18.2 1.5 1 0 0 1 1 1 1 Calcium-dependent channel, 7TM region, putative phosphate RSN1_TM PF13967.6 ELR25248.1 - 1.6e-27 96.2 1.1 1.6e-27 96.2 1.1 3.5 3 1 0 3 3 3 1 Late exocytosis, associated with Golgi transport PHM7_cyt PF14703.6 ELR25248.1 - 2.5e-27 96.2 0.0 3.8e-27 95.6 0.0 1.3 1 0 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter GST_N_2 PF13409.6 ELR25249.1 - 2.4e-20 72.6 0.1 2.9e-19 69.1 0.0 2.2 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 ELR25249.1 - 2.8e-11 43.2 0.1 6.6e-11 42.1 0.1 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 ELR25249.1 - 5.3e-06 26.6 0.2 1.5e-05 25.1 0.2 1.8 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 ELR25249.1 - 7e-05 23.2 0.0 0.1 13.0 0.0 2.7 3 0 0 3 3 3 2 Glutathione S-transferase, N-terminal domain GST_C_6 PF17171.4 ELR25249.1 - 0.055 13.3 0.0 0.12 12.2 0.0 1.5 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain Rap_GAP PF02145.15 ELR25250.1 - 7.7e-62 208.2 0.0 1.4e-61 207.3 0.0 1.4 1 0 0 1 1 1 1 Rap/ran-GAP Gtr1_RagA PF04670.12 ELR25252.1 - 8.5e-101 336.1 0.9 1.1e-100 335.8 0.9 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Roc PF08477.13 ELR25252.1 - 1.7e-08 34.7 0.1 1.1e-07 32.1 0.0 2.2 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 ELR25252.1 - 3.9e-07 29.8 0.1 1.2e-06 28.2 0.0 1.8 2 0 0 2 2 2 1 Ras family Arf PF00025.21 ELR25252.1 - 2.8e-06 26.9 0.0 4.7e-06 26.2 0.0 1.4 1 0 0 1 1 1 1 ADP-ribosylation factor family RETICULATA-like PF11891.8 ELR25252.1 - 0.098 12.5 0.0 0.17 11.7 0.0 1.4 1 0 0 1 1 1 0 Protein RETICULATA-related HSP20 PF00011.21 ELR25253.1 - 5.3e-05 23.3 0.0 0.00012 22.1 0.0 1.7 1 0 0 1 1 1 1 Hsp20/alpha crystallin family AHSP PF09236.10 ELR25253.1 - 0.17 12.4 0.2 0.3 11.6 0.2 1.3 1 0 0 1 1 1 0 Alpha-haemoglobin stabilising protein DUF1499 PF07386.11 ELR25254.1 - 2.4e-10 41.0 0.5 6.9e-10 39.5 0.5 1.8 1 1 0 1 1 1 1 Protein of unknown function (DUF1499) DUF2815 PF10991.8 ELR25254.1 - 0.14 12.1 0.0 0.23 11.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2815) Skp1_POZ PF03931.15 ELR25255.1 - 4.1e-20 71.7 0.2 1.3e-19 70.1 0.2 1.9 1 1 0 1 1 1 1 Skp1 family, tetramerisation domain Skp1 PF01466.19 ELR25255.1 - 2.7e-16 59.4 1.5 3.8e-16 58.9 0.8 1.7 2 0 0 2 2 2 1 Skp1 family, dimerisation domain ORF45 PF17620.2 ELR25256.1 - 0.23 11.6 1.1 0.75 9.9 0.7 1.7 1 1 1 2 2 2 0 Family of unknown function UCH PF00443.29 ELR25258.1 - 4.4e-47 160.7 3.0 5e-47 160.5 1.4 2.0 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 ELR25258.1 - 2.7e-24 86.3 1.4 1.7e-23 83.7 0.5 2.7 3 0 0 3 3 3 1 Ubiquitin carboxyl-terminal hydrolase Pkinase_Tyr PF07714.17 ELR25259.1 - 2.8e-101 338.2 0.0 2.1e-56 191.1 0.0 3.3 2 1 1 3 3 3 3 Protein tyrosine kinase Pkinase PF00069.25 ELR25259.1 - 7.1e-88 294.4 0.0 1.8e-45 155.4 0.0 3.2 2 1 1 3 3 3 3 Protein kinase domain PBP_like_2 PF12849.7 ELR25259.1 - 3.7e-32 112.1 19.1 4.5e-18 65.9 1.6 2.7 3 0 0 3 3 3 2 PBP superfamily domain Guanylate_cyc PF00211.20 ELR25259.1 - 1.1e-14 54.5 0.0 2.2e-14 53.5 0.0 1.5 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain APH PF01636.23 ELR25259.1 - 3.2e-07 30.5 0.0 0.00021 21.3 0.0 2.6 2 0 0 2 2 2 2 Phosphotransferase enzyme family EGF_2 PF07974.13 ELR25259.1 - 0.00011 22.5 12.3 0.00022 21.5 12.3 1.5 1 0 0 1 1 1 1 EGF-like domain Haspin_kinase PF12330.8 ELR25259.1 - 0.00042 19.4 0.0 0.043 12.8 0.0 2.2 2 0 0 2 2 2 1 Haspin like kinase domain Kinase-like PF14531.6 ELR25259.1 - 0.00049 19.5 0.0 0.29 10.4 0.0 2.3 2 0 0 2 2 2 2 Kinase-like FTA2 PF13095.6 ELR25259.1 - 0.0018 18.0 0.0 0.015 14.9 0.0 2.3 2 0 0 2 2 2 1 Kinetochore Sim4 complex subunit FTA2 Pkinase_fungal PF17667.1 ELR25259.1 - 0.0027 16.6 0.0 0.54 9.0 0.0 2.1 2 0 0 2 2 2 2 Fungal protein kinase TMEM154 PF15102.6 ELR25259.1 - 0.036 14.0 0.0 0.071 13.0 0.0 1.4 1 0 0 1 1 1 0 TMEM154 protein family RIO1 PF01163.22 ELR25259.1 - 0.057 13.0 0.8 1.5 8.3 0.2 2.4 2 0 0 2 2 2 0 RIO1 family Kdo PF06293.14 ELR25259.1 - 0.074 12.4 0.0 14 4.9 0.0 2.5 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family I-EGF_1 PF18372.1 ELR25259.1 - 0.25 11.5 5.2 0.49 10.5 5.2 1.4 1 0 0 1 1 1 0 Integrin beta epidermal growth factor like domain 1 EGF PF00008.27 ELR25259.1 - 0.96 9.8 6.8 1.9 8.9 6.8 1.5 1 0 0 1 1 1 0 EGF-like domain PHBC_N PF12551.8 ELR25259.1 - 1.1 9.0 4.1 23 4.9 0.0 3.4 3 0 0 3 3 3 0 Poly-beta-hydroxybutyrate polymerase N terminal Glyoxalase PF00903.25 ELR25260.1 - 2.3e-10 40.7 0.3 4e-05 23.8 0.0 2.2 2 0 0 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_4 PF13669.6 ELR25260.1 - 6e-07 29.7 1.0 0.0026 18.0 0.0 3.3 2 1 1 3 3 3 3 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_5 PF14696.6 ELR25260.1 - 2.1e-06 27.9 0.5 2.3e-05 24.6 0.1 2.7 3 0 0 3 3 3 1 Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal Glyoxalase_3 PF13468.6 ELR25260.1 - 0.025 14.7 0.9 0.22 11.6 0.3 2.6 2 1 0 2 2 2 0 Glyoxalase-like domain Git3 PF11710.8 ELR25261.1 - 3.5e-14 53.1 12.5 7e-14 52.1 12.5 1.4 1 0 0 1 1 1 1 G protein-coupled glucose receptor regulating Gpa2 GPR_Gpa2_C PF11970.8 ELR25261.1 - 1.1e-05 25.4 1.5 1.7e-05 24.8 0.1 2.1 2 0 0 2 2 2 1 G protein-coupled glucose receptor regulating Gpa2 C-term 7tm_1 PF00001.21 ELR25261.1 - 0.00023 20.6 9.9 0.00029 20.2 9.9 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) YrhK PF14145.6 ELR25261.1 - 0.14 12.1 2.8 3.2 7.7 0.6 2.7 1 1 1 2 2 2 0 YrhK-like protein Orf78 PF06024.12 ELR25261.1 - 9.5 6.6 6.1 2.5 8.5 0.5 2.4 2 0 0 2 2 2 0 Orf78 (ac78) Cpn60_TCP1 PF00118.24 ELR25263.1 - 1.2e-141 472.8 14.0 1.4e-141 472.5 14.0 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Xpo1 PF08389.12 ELR25264.1 - 2.1e-36 125.2 14.0 4.3e-36 124.2 1.2 5.2 6 0 0 6 6 6 1 Exportin 1-like protein DCB PF16213.5 ELR25264.1 - 0.086 12.5 2.5 0.14 11.8 0.0 2.6 3 0 0 3 3 3 0 Dimerisation and cyclophilin-binding domain of Mon2 adh_short_C2 PF13561.6 ELR25264.1 - 0.13 11.8 0.1 20 4.6 0.1 2.4 2 0 0 2 2 2 0 Enoyl-(Acyl carrier protein) reductase HEAT PF02985.22 ELR25264.1 - 0.37 11.2 1.4 17 6.0 0.0 4.1 4 0 0 4 4 4 0 HEAT repeat PB1 PF00564.24 ELR25265.1 - 3.2e-14 52.6 0.0 7.2e-14 51.5 0.0 1.6 1 0 0 1 1 1 1 PB1 domain UBA_4 PF14555.6 ELR25265.1 - 0.09 12.6 0.0 1.2 9.0 0.0 2.6 2 0 0 2 2 2 0 UBA-like domain Pkinase_Tyr PF07714.17 ELR25266.1 - 2.9e-126 420.0 0.0 2.7e-62 210.4 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 ELR25266.1 - 4.1e-106 354.2 0.0 2.5e-55 187.7 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Guanylate_cyc PF00211.20 ELR25266.1 - 7.8e-15 55.0 0.0 1.3e-14 54.2 0.0 1.3 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain APH PF01636.23 ELR25266.1 - 1.7e-07 31.4 0.4 0.00025 21.1 0.1 2.8 2 1 0 2 2 2 2 Phosphotransferase enzyme family EGF_2 PF07974.13 ELR25266.1 - 3.6e-05 24.0 12.4 7.5e-05 23.0 12.4 1.6 1 0 0 1 1 1 1 EGF-like domain Kinase-like PF14531.6 ELR25266.1 - 8.6e-05 22.0 0.0 0.19 11.0 0.0 2.9 3 0 0 3 3 3 2 Kinase-like Haspin_kinase PF12330.8 ELR25266.1 - 0.00022 20.3 0.0 0.03 13.3 0.0 2.2 2 0 0 2 2 2 1 Haspin like kinase domain Pkinase_fungal PF17667.1 ELR25266.1 - 0.0013 17.6 0.0 0.35 9.6 0.0 2.2 2 0 0 2 2 2 2 Fungal protein kinase FTA2 PF13095.6 ELR25266.1 - 0.002 17.8 0.0 0.027 14.1 0.0 2.6 3 1 0 3 3 3 1 Kinetochore Sim4 complex subunit FTA2 Kdo PF06293.14 ELR25266.1 - 0.0048 16.3 0.2 3.4 7.0 0.0 2.5 2 0 0 2 2 2 2 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 ELR25266.1 - 0.0062 16.1 1.4 1 8.9 0.5 2.5 2 1 0 2 2 2 1 RIO1 family EGF_Tenascin PF18720.1 ELR25266.1 - 0.015 15.3 10.3 0.037 14.1 10.3 1.6 1 0 0 1 1 1 0 Tenascin EGF domain I-EGF_1 PF18372.1 ELR25266.1 - 0.031 14.4 4.2 0.064 13.4 4.2 1.5 1 0 0 1 1 1 0 Integrin beta epidermal growth factor like domain 1 TMEM154 PF15102.6 ELR25266.1 - 0.079 12.9 0.0 0.22 11.4 0.0 1.7 1 0 0 1 1 1 0 TMEM154 protein family PHBC_N PF12551.8 ELR25266.1 - 0.079 12.7 4.6 1.4 8.7 0.0 3.2 3 0 0 3 3 3 0 Poly-beta-hydroxybutyrate polymerase N terminal EGF PF00008.27 ELR25266.1 - 0.091 13.1 6.5 0.18 12.1 6.5 1.5 1 0 0 1 1 1 0 EGF-like domain Seadorna_VP7 PF07387.11 ELR25266.1 - 0.14 11.2 0.1 0.56 9.2 0.0 1.8 2 0 0 2 2 2 0 Seadornavirus VP7 HMD PF03201.16 ELR25266.1 - 0.16 12.2 0.2 0.61 10.3 0.0 2.0 2 0 0 2 2 2 0 H2-forming N5,N10-methylene-tetrahydromethanopterin dehydrogenase hEGF PF12661.7 ELR25266.1 - 2.3 9.0 11.9 0.13 12.9 6.3 2.0 2 0 0 2 2 1 0 Human growth factor-like EGF RAP1 PF07218.11 ELR25266.1 - 8.5 4.5 4.7 15 3.7 4.7 1.3 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) PBP_like_2 PF12849.7 ELR25267.1 - 2.8e-22 79.7 4.0 3.2e-10 40.2 2.1 2.1 2 0 0 2 2 2 2 PBP superfamily domain Perilipin PF03036.16 ELR25268.1 - 3.2e-09 36.3 8.4 3.2e-09 36.3 8.4 2.5 2 1 0 2 2 2 1 Perilipin family Opi1 PF08618.10 ELR25268.1 - 2.4e-05 23.8 0.1 2.4e-05 23.8 0.1 2.2 3 0 0 3 3 3 1 Transcription factor Opi1 SAPS PF04499.15 ELR25268.1 - 0.0088 14.9 7.0 0.012 14.4 7.0 1.3 1 0 0 1 1 1 1 SIT4 phosphatase-associated protein DUF4667 PF15700.5 ELR25268.1 - 0.14 12.2 4.9 0.22 11.6 4.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4667) CwsA PF10814.8 ELR25268.1 - 0.54 10.4 3.1 1.1 9.4 0.6 2.3 1 1 1 2 2 2 0 Cell wall synthesis protein CwsA Cwf_Cwc_15 PF04889.12 ELR25268.1 - 4 7.1 19.1 0.22 11.2 13.6 1.7 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein Cwf_Cwc_15 PF04889.12 ELR25269.1 - 0.002 17.9 6.7 0.0023 17.7 6.7 1.1 1 0 0 1 1 1 1 Cwf15/Cwc15 cell cycle control protein Sigma70_ner PF04546.13 ELR25269.1 - 0.0069 16.3 7.8 0.008 16.1 7.8 1.1 1 0 0 1 1 1 1 Sigma-70, non-essential region DUF3069 PF11269.8 ELR25269.1 - 0.16 12.3 1.5 0.24 11.6 1.5 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3069) Rubis-subs-bind PF09273.11 ELR25271.1 - 1.2e-12 48.7 0.3 2e-12 47.9 0.3 1.4 1 0 0 1 1 1 1 Rubisco LSMT substrate-binding SET PF00856.28 ELR25271.1 - 9.6e-10 39.1 0.0 1.6e-09 38.4 0.0 1.3 1 0 0 1 1 1 1 SET domain MAM33 PF02330.16 ELR25272.1 - 3.5e-13 50.0 15.6 1e-06 28.9 8.5 2.1 1 1 1 2 2 2 2 Mitochondrial glycoprotein PAXIP1_C PF15364.6 ELR25272.1 - 0.015 15.6 4.5 0.027 14.8 4.5 1.5 1 0 0 1 1 1 0 PAXIP1-associated-protein-1 C term PTIP binding protein XAP5 PF04921.14 ELR25272.1 - 0.023 14.5 3.0 0.035 14.0 3.0 1.3 1 0 0 1 1 1 0 XAP5, circadian clock regulator NOA36 PF06524.12 ELR25272.1 - 0.024 14.0 1.3 0.031 13.6 1.3 1.2 1 0 0 1 1 1 0 NOA36 protein Na_trans_assoc PF06512.13 ELR25272.1 - 0.073 13.3 3.9 0.099 12.9 3.9 1.2 1 0 0 1 1 1 0 Sodium ion transport-associated Fungal_lectin PF07938.12 ELR25272.1 - 0.075 12.4 0.0 1.3 8.4 0.0 2.0 2 0 0 2 2 2 0 Fungal fucose-specific lectin Pox_Ag35 PF03286.14 ELR25272.1 - 0.11 12.3 3.0 0.18 11.5 3.0 1.3 1 0 0 1 1 1 0 Pox virus Ag35 surface protein DUF2457 PF10446.9 ELR25272.1 - 2.9 7.0 11.3 11 5.0 9.8 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2457) LSM PF01423.22 ELR25273.1 - 7.2e-17 60.8 0.1 1e-16 60.4 0.1 1.2 1 0 0 1 1 1 1 LSM domain Pept_tRNA_hydro PF01195.19 ELR25274.1 - 8.3e-38 130.0 0.0 9.3e-38 129.9 0.0 1.0 1 0 0 1 1 1 1 Peptidyl-tRNA hydrolase Pam16 PF03656.13 ELR25275.1 - 3.4e-24 85.2 0.1 3.7e-22 78.7 0.1 2.4 1 1 0 1 1 1 1 Pam16 Ank_2 PF12796.7 ELR25275.1 - 1e-10 42.0 0.0 3.3e-10 40.4 0.0 1.9 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ELR25275.1 - 3.3e-08 33.9 0.1 8.3e-06 26.3 0.0 3.4 1 1 3 4 4 4 3 Ankyrin repeats (many copies) SET PF00856.28 ELR25275.1 - 4.4e-08 33.7 0.0 5.7e-05 23.6 0.0 2.6 1 1 1 2 2 2 2 SET domain Ank_5 PF13857.6 ELR25275.1 - 1.2e-07 31.9 0.1 0.0024 18.1 0.0 3.2 1 1 2 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.30 ELR25275.1 - 1.6e-07 31.5 0.3 0.0033 17.8 0.0 3.2 4 0 0 4 4 4 2 Ankyrin repeat Ank_3 PF13606.6 ELR25275.1 - 4.4e-07 29.7 0.1 0.057 14.0 0.0 3.8 5 0 0 5 5 5 2 Ankyrin repeat DUF3447 PF11929.8 ELR25275.1 - 0.049 13.6 0.6 1.2 9.2 0.6 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF3447) ABC2_membrane_3 PF12698.7 ELR25276.1 - 5.6e-30 104.6 18.6 8e-30 104.1 18.6 1.1 1 0 0 1 1 1 1 ABC-2 family transporter protein ABC_tran PF00005.27 ELR25276.1 - 9.8e-23 81.2 0.0 1.8e-22 80.3 0.0 1.5 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 ELR25276.1 - 1.2e-10 41.7 0.0 2.6e-07 30.7 0.0 2.6 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 ELR25276.1 - 0.014 14.8 0.1 0.37 10.2 0.0 2.3 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain IstB_IS21 PF01695.17 ELR25276.1 - 0.037 13.8 0.0 3.4 7.4 0.1 2.3 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA_15 PF13175.6 ELR25276.1 - 0.17 11.6 0.0 6.6 6.3 0.0 2.2 2 0 0 2 2 2 0 AAA ATPase domain AAA_23 PF13476.6 ELR25276.1 - 0.42 11.1 1.5 0.83 10.1 1.5 1.4 1 0 0 1 1 1 0 AAA domain ABC2_membrane_5 PF13346.6 ELR25276.1 - 3.3 7.2 22.6 0.73 9.4 19.0 1.7 2 0 0 2 2 2 0 ABC-2 family transporter protein ABC2_membrane_3 PF12698.7 ELR25277.1 - 2.7e-24 85.9 11.5 3.6e-24 85.5 11.5 1.1 1 0 0 1 1 1 1 ABC-2 family transporter protein ABC_tran PF00005.27 ELR25277.1 - 3.8e-23 82.5 0.0 7.5e-23 81.6 0.0 1.5 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 ELR25277.1 - 3.6e-10 40.2 0.0 3.1e-08 33.8 0.0 2.3 2 0 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 ELR25277.1 - 0.0023 18.4 0.0 0.0053 17.3 0.0 1.5 1 0 0 1 1 1 1 AAA domain RsgA_GTPase PF03193.16 ELR25277.1 - 0.033 14.1 0.0 0.068 13.1 0.0 1.4 1 0 0 1 1 1 0 RsgA GTPase AAA_15 PF13175.6 ELR25277.1 - 0.052 13.3 0.0 1 9.0 0.0 2.2 2 0 0 2 2 2 0 AAA ATPase domain AAA_16 PF13191.6 ELR25277.1 - 0.11 12.9 0.0 0.24 11.8 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain TsaE PF02367.17 ELR25277.1 - 0.17 11.9 0.4 0.51 10.3 0.0 1.9 3 0 0 3 3 3 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE TANGO2 PF05742.12 ELR25278.1 - 2.7e-13 50.5 0.0 1.5e-12 48.1 0.0 1.8 1 1 0 1 1 1 1 Transport and Golgi organisation 2 DER1 PF04511.15 ELR25279.1 - 3.8e-43 147.7 8.5 4.4e-43 147.4 8.5 1.0 1 0 0 1 1 1 1 Der1-like family Rhomboid PF01694.22 ELR25279.1 - 0.063 13.3 9.7 0.078 13.0 8.3 1.8 2 1 0 2 2 2 0 Rhomboid family CH PF00307.31 ELR25280.1 - 5.6e-46 155.2 0.0 1.2e-15 57.7 0.0 3.4 3 0 0 3 3 3 3 Calponin homology (CH) domain RhoGEF PF00621.20 ELR25280.1 - 7.3e-41 140.4 1.2 1.6e-40 139.3 1.2 1.6 1 0 0 1 1 1 1 RhoGEF domain CAMSAP_CH PF11971.8 ELR25280.1 - 2.2e-06 27.4 0.6 0.28 11.0 0.0 4.0 4 0 0 4 4 4 2 CAMSAP CH domain CDC24 PF06395.11 ELR25280.1 - 2.6e-06 27.6 0.1 0.038 14.3 0.1 2.8 2 1 0 2 2 2 2 CDC24 Calponin PH PF00169.29 ELR25280.1 - 0.0027 18.2 0.0 0.0099 16.4 0.0 2.1 2 0 0 2 2 2 1 PH domain HHH_4 PF14490.6 ELR25280.1 - 0.0045 16.9 0.1 3 7.9 0.1 2.5 2 0 0 2 2 2 2 Helix-hairpin-helix containing domain Ribosomal_60s PF00428.19 ELR25280.1 - 4.8 7.8 0.0 4.8 7.8 0.0 3.7 5 0 0 5 5 5 0 60s Acidic ribosomal protein Peptidase_M14 PF00246.24 ELR25281.1 - 1.7e-92 310.3 0.9 2e-92 310.1 0.9 1.0 1 0 0 1 1 1 1 Zinc carboxypeptidase Propep_M14 PF02244.16 ELR25281.1 - 0.0062 16.9 0.0 0.013 15.9 0.0 1.5 1 0 0 1 1 1 1 Carboxypeptidase activation peptide BTB PF00651.31 ELR25283.1 - 6.3e-25 87.6 0.0 3.2e-24 85.3 0.0 1.9 1 1 1 2 2 2 1 BTB/POZ domain Laminin_G_3 PF13385.6 ELR25283.1 - 6.6e-18 65.3 0.0 9.9e-18 64.7 0.0 1.2 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily BACK PF07707.15 ELR25283.1 - 1.9e-05 24.7 0.1 0.038 14.1 0.0 2.6 2 0 0 2 2 2 2 BTB And C-terminal Kelch Skp1_POZ PF03931.15 ELR25283.1 - 0.019 15.1 0.0 0.04 14.1 0.0 1.5 1 0 0 1 1 1 0 Skp1 family, tetramerisation domain Pentaxin PF00354.17 ELR25283.1 - 0.14 11.9 0.0 0.24 11.1 0.0 1.4 1 0 0 1 1 1 0 Pentaxin family Gln-synt_C PF00120.24 ELR25284.1 - 1.5e-95 320.1 0.0 1.9e-95 319.8 0.0 1.1 1 0 0 1 1 1 1 Glutamine synthetase, catalytic domain TFIIA PF03153.13 ELR25285.1 - 0.0068 16.4 23.6 0.0094 16.0 23.6 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit RasGEF PF00617.19 ELR25286.1 - 9.6e-54 182.3 2.1 5.2e-53 179.9 1.0 2.2 2 0 0 2 2 2 1 RasGEF domain RasGEF_N PF00618.20 ELR25286.1 - 4.2e-16 59.1 0.0 2.5e-15 56.6 0.0 2.2 2 0 0 2 2 2 1 RasGEF N-terminal motif PH PF00169.29 ELR25286.1 - 8.5e-16 58.4 0.0 3.2e-08 34.0 0.1 2.6 2 0 0 2 2 2 2 PH domain TFIIA PF03153.13 ELR25286.1 - 6 6.7 9.9 12 5.8 9.9 1.4 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit adh_short PF00106.25 ELR25287.1 - 7.7e-32 110.3 0.0 1.1e-31 109.8 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ELR25287.1 - 2.8e-29 102.3 0.0 3.9e-29 101.9 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ELR25287.1 - 2.6e-06 27.5 0.1 3.7e-06 27.0 0.1 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 ELR25287.1 - 0.13 11.7 0.0 0.32 10.4 0.0 1.7 2 0 0 2 2 2 0 NAD dependent epimerase/dehydratase family 2-Hacid_dh_C PF02826.19 ELR25287.1 - 0.16 11.4 0.2 0.35 10.2 0.1 1.6 1 1 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain MFS_1 PF07690.16 ELR25288.1 - 9.6e-13 47.8 25.8 9.6e-13 47.8 25.8 1.4 1 1 0 1 1 1 1 Major Facilitator Superfamily DUF1616 PF07760.11 ELR25288.1 - 0.14 11.5 1.4 0.3 10.4 1.4 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF1616) DENN PF02141.21 ELR25289.1 - 1.5e-21 77.2 6.7 3.1e-20 72.9 0.1 3.3 4 0 0 4 4 4 2 DENN (AEX-3) domain uDENN PF03456.18 ELR25289.1 - 0.0055 17.4 0.1 0.051 14.3 0.2 2.6 2 1 0 2 2 2 1 uDENN domain RapH_N PF18801.1 ELR25289.1 - 0.73 10.0 3.5 8.4 6.6 0.0 2.8 2 0 0 2 2 2 0 response regulator aspartate phosphatase H, N terminal RRM_1 PF00076.22 ELR25290.1 - 5.6e-21 74.1 0.0 7.2e-21 73.8 0.0 1.1 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 ELR25290.1 - 0.0011 19.1 0.0 0.0016 18.5 0.0 1.4 1 1 0 1 1 1 1 RNA recognition motif GRP PF07172.11 ELR25290.1 - 0.32 11.7 20.3 0.51 11.1 20.3 1.4 1 0 0 1 1 1 0 Glycine rich protein family LSM PF01423.22 ELR25291.1 - 2.6e-18 65.4 0.0 3.1e-18 65.2 0.0 1.1 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 ELR25291.1 - 0.0069 16.5 0.0 0.0091 16.1 0.0 1.2 1 0 0 1 1 1 1 Ataxin 2 SM domain DUF150_C PF17384.2 ELR25291.1 - 0.0075 16.4 0.0 0.0094 16.1 0.0 1.2 1 0 0 1 1 1 1 RimP C-terminal SH3 domain NHL PF01436.21 ELR25292.1 - 6.2e-40 133.3 29.8 1.1e-10 41.0 0.6 8.2 7 1 0 7 7 7 5 NHL repeat SGL PF08450.12 ELR25292.1 - 3.7e-11 43.1 2.2 2.9e-06 27.1 0.0 3.8 3 1 0 3 3 3 2 SMP-30/Gluconolactonase/LRE-like region DUF5128 PF17170.4 ELR25292.1 - 1.2e-10 41.0 1.9 0.026 13.7 0.2 5.0 3 1 1 5 5 5 3 6-bladed beta-propeller zf-RING_2 PF13639.6 ELR25292.1 - 1.3e-06 28.7 11.4 2.4e-06 27.8 11.4 1.5 1 0 0 1 1 1 1 Ring finger domain Ldl_recept_b PF00058.17 ELR25292.1 - 3.1e-06 27.6 0.1 2.4 8.7 0.0 5.0 5 0 0 5 5 5 2 Low-density lipoprotein receptor repeat class B zf-C3HC4_2 PF13923.6 ELR25292.1 - 1.7e-05 24.6 10.4 3.3e-05 23.6 10.4 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 ELR25292.1 - 5.6e-05 22.9 7.6 0.00011 22.0 7.6 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Phytase-like PF13449.6 ELR25292.1 - 0.00097 19.2 0.8 0.24 11.3 0.0 3.6 2 1 1 4 4 4 1 Esterase-like activity of phytase Arylesterase PF01731.20 ELR25292.1 - 0.0023 18.1 0.0 12 6.2 0.0 3.5 3 0 0 3 3 3 0 Arylesterase zf-rbx1 PF12678.7 ELR25292.1 - 0.0038 17.5 6.6 0.0081 16.4 6.6 1.5 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 ELR25292.1 - 0.0043 16.9 9.2 0.0075 16.1 9.2 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 ELR25292.1 - 0.0057 16.7 8.1 0.013 15.5 8.1 1.6 1 0 0 1 1 1 1 RING-type zinc-finger Lactonase PF10282.9 ELR25292.1 - 0.0068 15.7 0.1 1.1 8.5 0.0 3.0 2 1 1 4 4 4 1 Lactonase, 7-bladed beta-propeller zf-RING_10 PF16685.5 ELR25292.1 - 0.012 15.7 7.7 0.02 15.0 7.7 1.3 1 0 0 1 1 1 0 zinc RING finger of MSL2 zf-RING_5 PF14634.6 ELR25292.1 - 0.024 14.6 7.2 0.041 13.8 7.2 1.4 1 0 0 1 1 1 0 zinc-RING finger domain zf-C3HC4_4 PF15227.6 ELR25292.1 - 0.032 14.4 10.4 0.06 13.5 10.4 1.5 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING SBBP PF06739.11 ELR25292.1 - 0.032 14.2 0.0 0.44 10.6 0.0 2.7 4 0 0 4 4 3 0 Beta-propeller repeat BiPBP_C PF06832.12 ELR25292.1 - 0.039 14.0 7.8 25 5.0 0.1 4.5 4 0 0 4 4 4 0 Penicillin-Binding Protein C-terminus Family Phage_fiber_C PF06820.12 ELR25292.1 - 0.081 13.3 0.7 69 3.9 0.1 4.2 5 0 0 5 5 4 0 Putative prophage tail fibre C-terminus zf-RING_6 PF14835.6 ELR25292.1 - 0.12 12.3 3.4 0.2 11.6 3.4 1.3 1 0 0 1 1 1 0 zf-RING of BARD1-type protein M PF02370.16 ELR25292.1 - 0.86 10.4 2.4 5.9 7.8 0.4 2.3 2 0 0 2 2 2 0 M protein repeat zf-RING_4 PF14570.6 ELR25292.1 - 4 7.3 7.3 10 6.0 7.3 1.7 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain GTP1_OBG PF01018.22 ELR25292.1 - 6 6.4 8.6 15 5.2 2.3 2.9 1 1 2 3 3 3 0 GTP1/OBG Pkinase_Tyr PF07714.17 ELR25293.1 - 8.4e-49 166.2 0.0 2e-48 164.9 0.0 1.6 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ELR25293.1 - 3.3e-43 148.0 0.0 1.2e-42 146.1 0.0 1.9 1 1 0 1 1 1 1 Protein kinase domain Ank PF00023.30 ELR25293.1 - 1.6e-16 59.9 0.0 1.7e-06 28.2 0.0 3.4 4 0 0 4 4 4 2 Ankyrin repeat Ank_5 PF13857.6 ELR25293.1 - 2.1e-16 59.8 0.1 2.5e-09 37.2 0.0 2.5 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 ELR25293.1 - 1.5e-15 57.6 0.3 5.3e-14 52.6 0.0 2.4 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ELR25293.1 - 2.5e-13 50.2 0.2 9e-08 32.5 0.1 2.6 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 ELR25293.1 - 4.2e-10 39.0 0.0 0.00019 21.6 0.0 3.3 3 0 0 3 3 3 2 Ankyrin repeat Exonuc_VII_L PF02601.15 ELR25293.1 - 0.73 9.3 3.9 1.1 8.8 3.9 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF16 PF01519.16 ELR25293.1 - 0.99 9.9 5.4 0.89 10.1 3.9 1.7 2 0 0 2 2 2 0 Protein of unknown function DUF16 DUF3552 PF12072.8 ELR25293.1 - 6.2 6.2 27.2 12 5.2 14.8 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF3552) RhoGAP PF00620.27 ELR25295.1 - 9.4e-30 103.4 0.0 1.6e-29 102.7 0.0 1.3 1 0 0 1 1 1 1 RhoGAP domain DEP PF00610.21 ELR25295.1 - 6.3e-08 32.6 0.0 1.2e-07 31.7 0.0 1.5 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) Apt1 PF10351.9 ELR25295.1 - 0.17 10.7 8.7 3.8 6.3 8.7 2.1 1 1 0 1 1 1 0 Golgi-body localisation protein domain Copper-bind PF00127.20 ELR25296.1 - 2.3e-05 24.7 0.0 3.6e-05 24.1 0.0 1.3 1 0 0 1 1 1 1 Copper binding proteins, plastocyanin/azurin family Keratin_assoc PF09775.9 ELR25296.1 - 0.024 14.3 4.3 0.11 12.2 0.7 2.3 2 0 0 2 2 2 0 Keratinocyte-associated protein 2 Ald_Xan_dh_C PF01315.22 ELR25296.1 - 0.14 12.5 0.0 0.28 11.6 0.0 1.5 1 0 0 1 1 1 0 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain XLF PF09302.11 ELR25298.1 - 4.9e-23 82.2 0.1 1.1e-22 81.1 0.1 1.5 1 0 0 1 1 1 1 XLF-Cernunnos, XRcc4-like factor, NHEJ component PKcGMP_CC PF16808.5 ELR25298.1 - 0.0084 15.9 0.5 0.022 14.6 0.5 1.7 1 0 0 1 1 1 1 Coiled-coil N-terminus of cGMP-dependent protein kinase NAD_binding_1 PF00175.21 ELR25299.1 - 1.1e-15 58.3 0.0 1.8e-15 57.5 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain Putative_PNPOx PF01243.20 ELR25299.1 - 1.9e-12 47.2 0.0 6.8e-08 32.6 0.0 2.8 2 1 0 2 2 2 2 Pyridoxamine 5'-phosphate oxidase NAD_binding_6 PF08030.12 ELR25299.1 - 0.0019 18.3 0.0 0.0057 16.8 0.0 1.7 2 0 0 2 2 2 1 Ferric reductase NAD binding domain FAD_binding_9 PF08021.11 ELR25299.1 - 0.0042 17.3 0.0 0.012 15.9 0.0 1.9 1 1 0 1 1 1 1 Siderophore-interacting FAD-binding domain FAD_binding_6 PF00970.24 ELR25299.1 - 0.046 14.1 0.0 0.24 11.8 0.0 2.1 2 0 0 2 2 2 0 Oxidoreductase FAD-binding domain DUF5548 PF17702.1 ELR25299.1 - 0.11 12.2 0.1 0.22 11.3 0.1 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5548) YjeF_N PF03853.15 ELR25300.1 - 4.8e-23 81.9 0.0 1.2e-22 80.6 0.0 1.7 1 1 0 1 1 1 1 YjeF-related protein N-terminus YjeF_N PF03853.15 ELR25301.1 - 2.1e-16 60.3 0.0 6.2e-15 55.5 0.0 2.1 1 1 1 2 2 2 2 YjeF-related protein N-terminus UDPGT PF00201.18 ELR25302.1 - 2.6e-14 52.9 0.0 1.9e-13 50.1 0.0 2.0 2 0 0 2 2 2 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.16 ELR25302.1 - 6e-12 45.9 0.0 1.3e-11 44.8 0.0 1.5 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain SnoaL_4 PF13577.6 ELR25302.1 - 4.8e-07 29.9 0.6 1.6e-06 28.3 0.2 2.1 2 0 0 2 2 2 1 SnoaL-like domain Glyco_transf_28 PF03033.20 ELR25302.1 - 0.004 17.2 0.0 0.0087 16.1 0.0 1.5 1 0 0 1 1 1 1 Glycosyltransferase family 28 N-terminal domain Glyco_transf_4 PF13439.6 ELR25302.1 - 0.0042 17.1 0.0 0.01 15.8 0.0 1.6 1 0 0 1 1 1 1 Glycosyltransferase Family 4 FAM176 PF14851.6 ELR25302.1 - 8.8 6.0 10.3 0.36 10.5 0.2 2.6 2 0 0 2 2 2 0 FAM176 family SIR2 PF02146.17 ELR25303.1 - 3.9e-32 111.6 0.3 8.9e-23 81.1 0.0 2.3 1 1 1 2 2 2 2 Sir2 family SAP PF02037.27 ELR25303.1 - 3.1e-11 42.8 0.8 8.5e-11 41.4 0.8 1.7 1 0 0 1 1 1 1 SAP domain Chromo PF00385.24 ELR25303.1 - 0.0035 17.2 0.2 0.0087 15.9 0.2 1.8 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain TPP_enzyme_M PF00205.22 ELR25303.1 - 0.13 12.0 0.0 23 4.7 0.0 2.6 3 0 0 3 3 3 0 Thiamine pyrophosphate enzyme, central domain FAM176 PF14851.6 ELR25303.1 - 0.15 11.7 16.5 2.9 7.6 1.3 3.3 3 0 0 3 3 3 0 FAM176 family Myc_N PF01056.18 ELR25303.1 - 0.3 10.9 16.1 0.038 13.9 1.7 3.0 3 0 0 3 3 3 0 Myc amino-terminal region zf-C2H2_3 PF13878.6 ELR25303.1 - 1.4 8.8 4.4 0.34 10.8 0.2 2.2 2 0 0 2 2 2 0 zinc-finger of acetyl-transferase ESCO AP3D1 PF06375.11 ELR25303.1 - 2.2 8.5 19.3 0.29 11.4 2.0 3.1 3 0 0 3 3 3 0 AP-3 complex subunit delta-1 RNase_H2_suC PF08615.11 ELR25303.1 - 8.9 6.5 10.9 12 6.1 0.1 3.1 2 1 0 3 3 3 0 Ribonuclease H2 non-catalytic subunit (Ylr154p-like) SprT-like PF10263.9 ELR25304.1 - 4.3e-14 52.3 0.0 2.5e-13 49.9 0.0 2.0 1 1 1 2 2 2 1 SprT-like family Peptidase_M76 PF09768.9 ELR25304.1 - 0.12 12.2 0.0 0.17 11.7 0.0 1.3 1 0 0 1 1 1 0 Peptidase M76 family NAD_binding_11 PF14833.6 ELR25305.1 - 9.5e-35 119.5 0.1 1.9e-34 118.6 0.1 1.5 1 0 0 1 1 1 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase NAD_binding_2 PF03446.15 ELR25305.1 - 1.5e-26 93.5 0.6 2.7e-26 92.6 0.6 1.4 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase HAD_2 PF13419.6 ELR25305.1 - 5.6e-22 78.7 0.0 8.3e-22 78.1 0.0 1.2 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 ELR25305.1 - 3.6e-15 56.8 0.3 1.1e-14 55.2 0.3 1.9 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 ELR25305.1 - 4e-08 33.9 0.1 1.2e-07 32.3 0.1 1.9 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase ApbA PF02558.16 ELR25305.1 - 0.0022 17.6 0.0 0.004 16.8 0.0 1.4 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA Sacchrp_dh_NADP PF03435.18 ELR25305.1 - 0.0099 16.1 0.0 0.029 14.6 0.0 1.8 1 1 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain UDPG_MGDP_dh PF00984.19 ELR25305.1 - 0.16 12.2 0.0 0.44 10.8 0.0 1.7 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, central domain CsbD PF05532.12 ELR25307.1 - 0.0015 18.4 0.2 0.0026 17.6 0.2 1.3 1 0 0 1 1 1 1 CsbD-like CsbD PF05532.12 ELR25308.1 - 0.002 18.0 0.2 0.0034 17.2 0.2 1.3 1 0 0 1 1 1 1 CsbD-like DnaJ_C PF01556.18 ELR25310.1 - 9.4e-39 132.9 0.1 1.8e-38 131.9 0.1 1.5 2 0 0 2 2 2 1 DnaJ C terminal domain DnaJ PF00226.31 ELR25310.1 - 5.3e-26 90.5 4.0 8.6e-26 89.9 4.0 1.3 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.19 ELR25310.1 - 4e-12 46.3 17.1 7.8e-12 45.4 17.1 1.5 1 0 0 1 1 1 1 DnaJ central domain Anti-TRAP PF15777.5 ELR25310.1 - 0.0006 19.7 19.1 0.013 15.4 6.7 2.5 1 1 1 2 2 2 2 Tryptophan RNA-binding attenuator protein inhibitory protein HypA PF01155.19 ELR25310.1 - 0.033 14.2 9.4 0.39 10.8 1.3 2.4 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA A2L_zn_ribbon PF08792.10 ELR25310.1 - 5.2 6.9 6.6 40 4.1 0.1 3.4 3 0 0 3 3 3 0 A2L zinc ribbon domain DZR PF12773.7 ELR25310.1 - 5.7 7.1 9.7 15 5.7 9.7 1.8 1 0 0 1 1 1 0 Double zinc ribbon MORN PF02493.20 ELR25311.1 - 4e-32 108.2 52.4 6.2e-05 22.6 1.6 9.5 10 0 0 10 10 10 8 MORN repeat WD40 PF00400.32 ELR25312.1 - 9.5e-34 114.9 16.1 4.8e-07 30.4 0.3 7.3 7 0 0 7 7 7 6 WD domain, G-beta repeat F-box-like PF12937.7 ELR25312.1 - 9.1e-13 47.9 0.1 1.7e-12 47.0 0.1 1.5 1 0 0 1 1 1 1 F-box-like ANAPC4_WD40 PF12894.7 ELR25312.1 - 3.6e-10 40.0 4.5 0.038 14.3 0.1 5.3 1 1 3 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain F-box PF00646.33 ELR25312.1 - 2.1e-09 37.0 0.1 4.2e-09 36.1 0.1 1.5 1 0 0 1 1 1 1 F-box domain Nup160 PF11715.8 ELR25312.1 - 0.00017 20.4 14.4 0.34 9.5 0.1 5.2 1 1 4 5 5 5 3 Nucleoporin Nup120/160 ELYS-bb PF16687.5 ELR25312.1 - 0.031 12.9 0.0 0.076 11.6 0.0 1.6 1 1 0 1 1 1 0 beta-propeller of ELYS nucleoporin ArsA_ATPase PF02374.15 ELR25313.1 - 1.6e-111 372.4 0.0 1.8e-111 372.2 0.0 1.0 1 0 0 1 1 1 1 Anion-transporting ATPase CbiA PF01656.23 ELR25313.1 - 1.4e-10 41.3 0.0 3.7e-10 40.0 0.0 1.7 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_31 PF13614.6 ELR25313.1 - 3.6e-10 40.1 0.2 1.7e-09 37.9 0.0 2.3 2 1 0 2 2 2 1 AAA domain ParA PF10609.9 ELR25313.1 - 7.8e-07 28.8 0.3 0.00079 19.0 0.0 2.3 2 0 0 2 2 2 2 NUBPL iron-transfer P-loop NTPase Fer4_NifH PF00142.18 ELR25313.1 - 1.7e-05 24.4 0.0 2.5e-05 23.9 0.0 1.4 1 0 0 1 1 1 1 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family CBP_BcsQ PF06564.12 ELR25313.1 - 0.0014 18.2 0.0 0.0039 16.7 0.0 1.7 2 0 0 2 2 2 1 Cellulose biosynthesis protein BcsQ NB-ARC PF00931.22 ELR25313.1 - 0.0036 16.5 0.0 0.0074 15.5 0.0 1.5 1 0 0 1 1 1 1 NB-ARC domain SRP54 PF00448.22 ELR25313.1 - 0.0074 15.9 0.1 0.021 14.4 0.0 1.7 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain PhoH PF02562.16 ELR25313.1 - 0.012 15.1 0.0 0.034 13.6 0.0 1.7 2 0 0 2 2 2 0 PhoH-like protein AAA_25 PF13481.6 ELR25313.1 - 0.027 14.1 0.2 0.08 12.5 0.2 1.8 1 1 0 1 1 1 0 AAA domain DUF1611 PF07755.11 ELR25313.1 - 0.033 13.5 0.0 0.33 10.2 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF1611_C) P-loop domain Zeta_toxin PF06414.12 ELR25313.1 - 0.072 12.4 0.0 0.12 11.7 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin CsbD PF05532.12 ELR25314.1 - 0.0019 18.1 0.2 0.0033 17.3 0.2 1.3 1 0 0 1 1 1 1 CsbD-like CsbD PF05532.12 ELR25315.1 - 0.0014 18.5 0.2 0.0027 17.6 0.2 1.4 1 0 0 1 1 1 1 CsbD-like CsbD PF05532.12 ELR25316.1 - 0.0016 18.3 0.2 0.0027 17.6 0.2 1.3 1 0 0 1 1 1 1 CsbD-like p450 PF00067.22 ELR25317.1 - 2.7e-67 227.5 0.0 1.8e-35 122.6 0.0 2.0 1 1 1 2 2 2 2 Cytochrome P450 DUF3987 PF13148.6 ELR25318.1 - 5.4 5.9 12.6 8.9 5.2 12.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3987) Dioxygenase_C PF00775.21 ELR25319.1 - 9.1e-10 38.3 0.2 1.5e-08 34.3 0.2 2.2 1 1 0 1 1 1 1 Dioxygenase Myosin_TH1 PF06017.13 ELR25320.1 - 0.00013 21.7 1.4 0.0044 16.7 0.1 2.5 3 0 0 3 3 3 2 Unconventional myosin tail, actin- and lipid-binding PAS_6 PF08348.11 ELR25320.1 - 0.069 13.0 0.1 0.18 11.7 0.1 1.7 1 0 0 1 1 1 0 YheO-like PAS domain RRM_5 PF13893.6 ELR25321.1 - 1.7e-59 198.9 0.7 3.1e-30 104.3 0.0 4.1 3 1 1 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.22 ELR25321.1 - 5.6e-41 138.2 0.0 4.8e-10 39.1 0.0 4.3 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_8 PF11835.8 ELR25321.1 - 2.2e-20 72.6 0.4 2.3e-17 63.0 0.2 2.5 2 0 0 2 2 2 2 RRM-like domain RRM_3 PF08777.11 ELR25321.1 - 5.4e-06 26.4 0.0 0.66 10.0 0.0 4.1 4 0 0 4 4 4 1 RNA binding motif Limkain-b1 PF11608.8 ELR25321.1 - 4.3e-05 23.5 0.0 0.079 13.0 0.0 4.0 4 0 0 4 4 4 1 Limkain b1 RRM_occluded PF16842.5 ELR25321.1 - 7.6e-05 22.5 0.0 0.21 11.5 0.1 4.0 4 0 0 4 4 4 1 Occluded RNA-recognition motif RL PF17797.1 ELR25321.1 - 0.0086 16.0 0.5 1.2 9.2 0.5 3.1 3 0 0 3 3 3 1 RL domain DUF4387 PF14330.6 ELR25321.1 - 0.14 12.9 0.1 4.3 8.1 0.0 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF4387) Ribonucleas_3_3 PF14622.6 ELR25322.1 - 3.5e-48 163.0 0.0 6.9e-24 84.4 0.0 2.2 2 0 0 2 2 2 2 Ribonuclease-III-like Ribonuclease_3 PF00636.26 ELR25322.1 - 8.9e-47 158.1 0.0 1.3e-23 83.6 0.0 2.9 3 0 0 3 3 3 2 Ribonuclease III domain dsrm PF00035.26 ELR25322.1 - 1.4e-09 38.5 0.0 3e-09 37.5 0.0 1.6 1 0 0 1 1 1 1 Double-stranded RNA binding motif PAZ PF02170.22 ELR25322.1 - 0.00019 21.2 0.0 0.00034 20.5 0.0 1.3 1 0 0 1 1 1 1 PAZ domain DND1_DSRM PF14709.7 ELR25322.1 - 0.0032 17.7 0.0 0.0064 16.7 0.0 1.5 1 0 0 1 1 1 1 double strand RNA binding domain from DEAD END PROTEIN 1 TFIID-31kDa PF02291.15 ELR25323.1 - 4.8e-37 126.7 0.0 5.6e-37 126.5 0.0 1.0 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit Bromo_TP PF07524.13 ELR25323.1 - 2.4e-09 37.1 0.0 3.4e-09 36.6 0.0 1.2 1 0 0 1 1 1 1 Bromodomain associated CENP-S PF15630.6 ELR25323.1 - 0.002 18.4 0.0 0.0028 18.0 0.0 1.2 1 0 0 1 1 1 1 CENP-S protein CENP-T_C PF15511.6 ELR25323.1 - 0.0073 16.4 0.0 0.0091 16.1 0.0 1.3 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold TAF PF02969.17 ELR25323.1 - 0.029 14.5 0.0 0.04 14.1 0.0 1.2 1 0 0 1 1 1 0 TATA box binding protein associated factor (TAF) RNase_PH PF01138.21 ELR25324.1 - 3.7e-28 98.6 0.1 1.7e-15 57.7 0.0 2.2 1 1 1 2 2 2 2 3' exoribonuclease family, domain 1 UPF0242 PF06785.11 ELR25325.1 - 0.0014 18.8 0.1 0.0015 18.6 0.1 1.1 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0242) N-terminus KxDL PF10241.9 ELR25325.1 - 0.0089 16.3 0.3 0.014 15.7 0.3 1.2 1 0 0 1 1 1 1 Uncharacterized conserved protein ATG16 PF08614.11 ELR25325.1 - 0.009 16.3 0.0 0.012 15.9 0.0 1.2 1 0 0 1 1 1 1 Autophagy protein 16 (ATG16) Troponin PF00992.20 ELR25325.1 - 0.014 15.7 0.1 0.015 15.6 0.1 1.1 1 0 0 1 1 1 0 Troponin DUF16 PF01519.16 ELR25325.1 - 0.039 14.4 0.2 0.054 14.0 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function DUF16 NPV_P10 PF05531.12 ELR25325.1 - 0.08 13.4 0.1 0.12 12.9 0.1 1.2 1 0 0 1 1 1 0 Nucleopolyhedrovirus P10 protein TMEM171 PF15471.6 ELR25325.1 - 0.2 10.6 0.3 0.25 10.3 0.3 1.1 1 0 0 1 1 1 0 Transmembrane protein family 171 MAGSP PF03082.14 ELR25325.1 - 0.22 11.1 0.2 0.3 10.6 0.2 1.1 1 0 0 1 1 1 0 Male accessory gland secretory protein zf-C2H2 PF00096.26 ELR25326.1 - 1.1e-06 28.7 6.5 0.0036 17.7 1.5 2.8 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 ELR25326.1 - 1.7e-06 28.4 5.9 0.003 18.2 1.3 3.0 2 0 0 2 2 2 2 C2H2-type zinc finger WRKY PF03106.15 ELR25326.1 - 3.8e-05 23.8 3.6 0.00013 22.1 3.6 2.0 1 0 0 1 1 1 1 WRKY DNA -binding domain zf-Di19 PF05605.12 ELR25326.1 - 0.00033 20.9 2.7 0.00066 19.9 2.7 1.5 1 0 0 1 1 1 1 Drought induced 19 protein (Di19), zinc-binding GAGA PF09237.11 ELR25326.1 - 0.00079 19.2 0.7 0.0029 17.4 0.7 2.0 1 0 0 1 1 1 1 GAGA factor Cys_rich_CPXG PF14255.6 ELR25326.1 - 0.024 14.5 0.4 0.084 12.8 0.4 1.9 1 0 0 1 1 1 0 Cysteine-rich CPXCG Zn-C2H2_12 PF18112.1 ELR25326.1 - 0.047 14.2 3.0 2.9 8.4 0.9 2.5 2 0 0 2 2 2 0 Autophagy receptor zinc finger-C2H2 domain Ogr_Delta PF04606.12 ELR25326.1 - 0.05 13.6 6.1 2.2 8.3 0.0 3.4 4 0 0 4 4 4 0 Ogr/Delta-like zinc finger zf-BED PF02892.15 ELR25326.1 - 0.056 13.5 5.6 35 4.5 5.6 2.6 1 1 0 1 1 1 0 BED zinc finger DZR PF12773.7 ELR25326.1 - 0.21 11.6 3.0 1.1 9.3 0.3 2.7 2 0 0 2 2 2 0 Double zinc ribbon zf-ribbon_3 PF13248.6 ELR25326.1 - 0.26 10.7 8.9 0.11 11.9 0.5 3.2 3 0 0 3 3 3 0 zinc-ribbon domain zf-C2H2_jaz PF12171.8 ELR25326.1 - 0.73 10.2 4.3 0.49 10.7 0.7 2.3 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zinc_ribbon_9 PF14369.6 ELR25326.1 - 2.9 8.2 5.2 2.6 8.4 0.7 2.8 2 0 0 2 2 2 0 zinc-ribbon Lar_restr_allev PF14354.6 ELR25326.1 - 4.5 7.7 7.8 12 6.3 0.4 4.0 4 1 0 4 4 4 0 Restriction alleviation protein Lar Zn-ribbon_8 PF09723.10 ELR25326.1 - 5.9 7.1 7.8 0.48 10.6 0.9 2.7 3 0 0 3 3 2 0 Zinc ribbon domain Ank_2 PF12796.7 ELR25327.1 - 5.1e-16 59.0 0.1 4e-08 33.7 0.0 4.3 3 1 1 4 4 4 3 Ankyrin repeats (3 copies) Ank_3 PF13606.6 ELR25327.1 - 4.6e-15 54.2 0.7 0.18 12.5 0.0 7.1 7 0 0 7 7 7 4 Ankyrin repeat Ank_4 PF13637.6 ELR25327.1 - 1.9e-13 50.7 0.5 6.4e-08 33.0 0.0 4.5 4 1 1 5 5 5 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 ELR25327.1 - 3.6e-07 30.3 0.8 0.0011 19.2 0.0 4.9 5 0 0 5 5 5 1 Ankyrin repeats (many copies) Ank PF00023.30 ELR25327.1 - 0.00059 20.2 9.2 3 8.4 0.0 6.6 8 0 0 8 8 8 1 Ankyrin repeat F-box-like PF12937.7 ELR25327.1 - 0.0018 18.1 0.0 0.0045 16.9 0.0 1.7 1 0 0 1 1 1 1 F-box-like NARP1 PF12569.8 ELR25328.1 - 0.025 13.5 2.7 0.027 13.4 2.7 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 Arif-1 PF06770.11 ELR25328.1 - 0.03 14.0 1.8 0.033 13.8 0.4 1.7 2 0 0 2 2 2 0 Actin-rearrangement-inducing factor (Arif-1) PA26 PF04636.13 ELR25328.1 - 0.084 11.8 0.0 0.12 11.3 0.0 1.2 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Neurokinin_B PF03823.14 ELR25328.1 - 2.4 8.3 3.8 2.2 8.4 0.1 2.8 2 1 0 3 3 3 0 Neurokinin B Connexin PF00029.19 ELR25328.1 - 4 7.1 6.1 2.4 7.9 2.0 2.0 2 0 0 2 2 2 0 Connexin DUF89 PF01937.19 ELR25331.1 - 4.5e-73 246.2 0.3 5.2e-73 246.0 0.3 1.0 1 0 0 1 1 1 1 Protein of unknown function DUF89 DUF615 PF04751.14 ELR25331.1 - 0.23 11.4 1.6 1.4 8.9 0.0 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF615) DisA_N PF02457.16 ELR25333.1 - 0.09 12.4 0.0 0.17 11.5 0.0 1.4 1 0 0 1 1 1 0 DisA bacterial checkpoint controller nucleotide-binding PUA PF01472.20 ELR25334.1 - 1.4e-09 37.7 0.2 2.7e-09 36.8 0.2 1.4 1 0 0 1 1 1 1 PUA domain PAT1 PF09770.9 ELR25334.1 - 0.25 9.6 0.0 0.25 9.6 0.0 5.0 5 1 1 6 6 6 0 Topoisomerase II-associated protein PAT1 DUF2407_C PF13373.6 ELR25334.1 - 0.29 11.3 1.2 1.8 8.7 1.7 2.1 2 0 0 2 2 2 0 DUF2407 C-terminal domain FtsJ PF01728.19 ELR25335.1 - 4.7e-68 228.8 0.0 5.5e-68 228.6 0.0 1.0 1 0 0 1 1 1 1 FtsJ-like methyltransferase Rad60-SLD PF11976.8 ELR25336.1 - 3.1e-21 75.0 0.0 4.6e-21 74.4 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.23 ELR25336.1 - 3.3e-07 30.0 0.0 4.8e-07 29.4 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin family SRP9-21 PF05486.12 ELR25336.1 - 0.061 13.7 0.1 0.089 13.2 0.1 1.2 1 0 0 1 1 1 0 Signal recognition particle 9 kDa protein (SRP9) U3_assoc_6 PF08640.11 ELR25336.1 - 0.14 12.2 0.3 0.31 11.1 0.0 1.6 2 0 0 2 2 2 0 U3 small nucleolar RNA-associated protein 6 MMR_HSR1 PF01926.23 ELR25337.1 - 1.6e-13 50.8 0.0 1.6e-11 44.3 0.0 2.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 ELR25337.1 - 2.4e-06 27.6 0.0 0.006 16.5 0.0 2.4 2 0 0 2 2 2 2 RsgA GTPase FeoB_N PF02421.18 ELR25337.1 - 4.2e-05 23.1 0.0 0.00046 19.7 0.0 2.1 2 0 0 2 2 2 1 Ferrous iron transport protein B GTP_EFTU PF00009.27 ELR25337.1 - 0.00054 19.5 0.2 1.2 8.7 0.0 2.9 2 1 1 3 3 3 2 Elongation factor Tu GTP binding domain Dynamin_N PF00350.23 ELR25337.1 - 0.0013 18.8 0.6 0.0013 18.8 0.6 3.2 3 1 1 4 4 4 1 Dynamin family Roc PF08477.13 ELR25337.1 - 0.0083 16.3 0.1 0.94 9.7 0.1 2.9 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase SUIM_assoc PF16619.5 ELR25337.1 - 0.03 14.4 0.3 0.03 14.4 0.3 3.4 5 0 0 5 5 5 0 Unstructured region C-term to UIM in Ataxin3 Sigma70_ner PF04546.13 ELR25337.1 - 9 6.1 20.7 0.59 10.0 5.0 2.7 2 0 0 2 2 2 0 Sigma-70, non-essential region Ribosomal_S11 PF00411.19 ELR25338.1 - 1.2e-21 77.1 0.2 1.5e-21 76.9 0.2 1.1 1 0 0 1 1 1 1 Ribosomal protein S11 CBM_25 PF03423.13 ELR25338.1 - 0.029 14.6 0.0 0.036 14.3 0.0 1.1 1 0 0 1 1 1 0 Carbohydrate binding domain (family 25) Proteasome PF00227.26 ELR25339.1 - 3.7e-38 130.9 0.0 4.1e-38 130.8 0.0 1.0 1 0 0 1 1 1 1 Proteasome subunit RPN7 PF10602.9 ELR25340.1 - 2.7e-62 209.5 1.7 4.6e-62 208.8 1.7 1.4 1 0 0 1 1 1 1 26S proteasome subunit RPN7 PCI PF01399.27 ELR25340.1 - 1.6e-17 63.9 0.0 5.2e-17 62.3 0.0 1.9 1 0 0 1 1 1 1 PCI domain TPR_7 PF13176.6 ELR25340.1 - 0.036 14.1 0.0 0.53 10.4 0.0 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF3958 PF13125.6 ELR25340.1 - 0.042 14.0 0.3 0.15 12.3 0.3 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF3958) TPR_2 PF07719.17 ELR25340.1 - 0.1 12.8 0.8 0.91 9.8 0.1 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat Enkurin PF13864.6 ELR25340.1 - 0.26 11.7 1.6 0.67 10.4 1.6 1.7 1 0 0 1 1 1 0 Calmodulin-binding Ribul_P_3_epim PF00834.19 ELR25341.1 - 1.9e-79 265.6 0.1 2.3e-79 265.4 0.1 1.0 1 0 0 1 1 1 1 Ribulose-phosphate 3 epimerase family QRPTase_C PF01729.19 ELR25341.1 - 0.0014 18.4 0.6 0.033 14.0 0.1 2.6 1 1 1 2 2 2 1 Quinolinate phosphoribosyl transferase, C-terminal domain OMPdecase PF00215.24 ELR25341.1 - 0.0045 16.6 0.3 0.0073 15.9 0.2 1.7 1 1 1 2 2 2 1 Orotidine 5'-phosphate decarboxylase / HUMPS family AP_endonuc_2 PF01261.24 ELR25341.1 - 0.016 14.6 0.0 0.16 11.4 0.0 2.3 2 1 0 2 2 2 0 Xylose isomerase-like TIM barrel JmjN PF02375.17 ELR25341.1 - 0.05 13.6 0.0 0.12 12.3 0.0 1.6 1 0 0 1 1 1 0 jmjN domain Pkinase_Tyr PF07714.17 ELR25342.1 - 1.4e-58 198.2 0.0 2.1e-58 197.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ELR25342.1 - 1.2e-51 175.6 0.0 1.6e-51 175.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain SH2 PF00017.24 ELR25342.1 - 7.5e-12 45.2 0.0 1.9e-11 43.9 0.0 1.7 1 0 0 1 1 1 1 SH2 domain Cbl_N2 PF02761.14 ELR25342.1 - 0.0033 18.1 0.0 0.0086 16.8 0.0 1.7 1 0 0 1 1 1 1 CBL proto-oncogene N-terminus, EF hand-like domain SH2_2 PF14633.6 ELR25342.1 - 0.12 11.7 0.5 0.79 9.1 0.0 2.1 2 0 0 2 2 2 0 SH2 domain SRP-alpha_N PF04086.13 ELR25342.1 - 0.71 9.7 12.6 1.2 9.1 12.6 1.2 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal NAM-associated PF14303.6 ELR25342.1 - 2.5 8.8 11.6 4.3 8.0 11.6 1.2 1 0 0 1 1 1 0 No apical meristem-associated C-terminal domain UCH PF00443.29 ELR25343.1 - 8.6e-79 264.6 0.0 1.2e-78 264.2 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase DUSP PF06337.12 ELR25343.1 - 1.4e-22 80.1 0.3 4.3e-22 78.6 0.3 1.9 1 0 0 1 1 1 1 DUSP domain UCH_1 PF13423.6 ELR25343.1 - 4.6e-16 59.3 0.3 1.6e-08 34.5 0.1 3.3 3 0 0 3 3 3 3 Ubiquitin carboxyl-terminal hydrolase Ubiquitin_3 PF14836.6 ELR25343.1 - 7e-09 35.6 0.0 2.8e-08 33.6 0.0 2.0 2 0 0 2 2 2 1 Ubiquitin-like domain USP7_C2 PF14533.6 ELR25343.1 - 3.7e-05 23.5 0.0 0.022 14.5 0.0 2.6 2 0 0 2 2 2 2 Ubiquitin-specific protease C-terminal ubiquitin PF00240.23 ELR25343.1 - 0.0088 15.8 0.0 0.74 9.6 0.0 3.1 3 0 0 3 3 3 1 Ubiquitin family RFX_DNA_binding PF02257.15 ELR25344.1 - 4.8e-44 148.9 0.3 2.9e-26 91.9 0.2 2.3 2 0 0 2 2 2 2 RFX DNA-binding domain Pox_D5 PF03288.16 ELR25344.1 - 4.8e-08 33.4 0.4 0.00028 21.3 0.0 3.2 3 1 1 4 4 4 2 Poxvirus D5 protein-like Cdc6_C PF09079.11 ELR25344.1 - 0.00024 21.0 0.0 1.4 9.0 0.0 3.1 3 0 0 3 3 3 2 CDC6, C terminal winged helix domain DUF5363 PF17320.2 ELR25344.1 - 0.0078 16.1 1.9 0.055 13.4 0.1 2.9 3 0 0 3 3 3 1 Family of unknown function (DUF5363) PBP1_TM PF14812.6 ELR25344.1 - 6.4 7.2 21.4 5.9 7.3 8.3 3.0 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DUF4637 PF15470.6 ELR25345.1 - 0.011 15.5 4.2 0.016 14.9 4.1 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4637) PBP1_TM PF14812.6 ELR25345.1 - 3 8.3 5.2 2 8.9 1.2 2.1 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Nic96 PF04097.14 ELR25346.1 - 3e-103 346.4 0.0 3.7e-103 346.1 0.0 1.1 1 0 0 1 1 1 1 Nup93/Nic96 Band_7 PF01145.25 ELR25347.1 - 1.8e-29 103.0 1.7 2.7e-29 102.5 1.7 1.3 1 0 0 1 1 1 1 SPFH domain / Band 7 family DUF1191 PF06697.12 ELR25347.1 - 0.0078 16.0 0.0 0.013 15.3 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1191) Band_7_1 PF13421.6 ELR25347.1 - 0.029 14.1 0.0 0.061 13.0 0.0 1.5 1 0 0 1 1 1 0 SPFH domain-Band 7 family HMG_box PF00505.19 ELR25348.1 - 9.4e-46 154.1 4.8 2.9e-22 78.8 0.8 2.3 2 0 0 2 2 2 2 HMG (high mobility group) box HMG_box_2 PF09011.10 ELR25348.1 - 5.3e-34 116.7 4.6 1.8e-17 63.7 0.2 2.3 2 0 0 2 2 2 2 HMG-box domain Ccdc124 PF06244.12 ELR25348.1 - 8.6e-05 23.1 10.9 0.055 14.0 0.3 3.6 2 1 2 4 4 4 2 Coiled-coil domain-containing protein 124 /Oxs1 CHDNT PF08073.12 ELR25348.1 - 0.00028 20.8 0.0 0.12 12.4 0.0 2.4 2 0 0 2 2 2 2 CHDNT (NUC034) domain DUF4483 PF14825.6 ELR25348.1 - 0.019 14.8 1.0 0.019 14.8 1.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4483) HTH_WhiA PF02650.14 ELR25348.1 - 0.027 14.8 0.0 0.58 10.5 0.0 2.4 2 0 0 2 2 2 0 WhiA C-terminal HTH domain RR_TM4-6 PF06459.12 ELR25348.1 - 0.074 12.9 12.2 0.35 10.7 3.0 2.0 1 1 1 2 2 2 0 Ryanodine Receptor TM 4-6 YABBY PF04690.13 ELR25348.1 - 0.27 11.8 11.6 1.6 9.3 5.9 2.7 1 1 2 3 3 3 0 YABBY protein TFIIF_alpha PF05793.12 ELR25348.1 - 1.6 7.3 23.1 1.7 7.2 11.3 2.1 2 0 0 2 2 2 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Ras PF00071.22 ELR25349.1 - 2.9e-16 59.5 0.0 4.5e-16 58.9 0.0 1.2 1 0 0 1 1 1 1 Ras family Mucin PF01456.17 ELR25350.1 - 0.11 12.5 30.6 0.27 11.2 30.6 1.6 1 0 0 1 1 1 0 Mucin-like glycoprotein Apt1 PF10351.9 ELR25350.1 - 1.3 7.8 11.1 1.6 7.5 11.1 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain Macoilin PF09726.9 ELR25350.1 - 1.3 7.5 11.3 1.6 7.1 11.3 1.0 1 0 0 1 1 1 0 Macoilin family Presenilin PF01080.17 ELR25350.1 - 1.6 7.4 9.9 2 7.1 9.9 1.1 1 0 0 1 1 1 0 Presenilin Dicty_REP PF05086.12 ELR25350.1 - 3.1 5.6 19.1 4 5.3 19.1 1.0 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Endomucin PF07010.12 ELR25350.1 - 3.8 7.4 17.7 5.4 6.9 17.7 1.1 1 0 0 1 1 1 0 Endomucin Kazal_1 PF00050.21 ELR25351.1 - 1e-05 25.4 3.7 1e-05 25.4 3.7 1.6 2 0 0 2 2 2 1 Kazal-type serine protease inhibitor domain Kazal_2 PF07648.15 ELR25351.1 - 0.0017 18.4 0.7 0.0017 18.4 0.7 1.7 2 0 0 2 2 2 1 Kazal-type serine protease inhibitor domain Macro PF01661.21 ELR25352.1 - 1.4e-38 131.6 0.1 1.9e-38 131.1 0.1 1.2 1 0 0 1 1 1 1 Macro domain DUF1861 PF08950.10 ELR25352.1 - 0.068 12.4 0.0 0.099 11.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1861) Kazal_1 PF00050.21 ELR25353.1 - 4.2e-05 23.5 3.7 4.2e-05 23.5 3.7 2.0 2 1 0 2 2 2 1 Kazal-type serine protease inhibitor domain Kazal_2 PF07648.15 ELR25353.1 - 0.051 13.7 2.6 0.051 13.7 2.6 2.0 2 0 0 2 2 2 0 Kazal-type serine protease inhibitor domain RNA_pol_Rpb4 PF03874.16 ELR25354.1 - 8.9e-24 84.2 3.4 1.1e-23 83.9 3.4 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb4 MDM31_MDM32 PF08118.11 ELR25355.1 - 7.2e-85 285.6 0.1 1.3e-40 139.6 0.0 3.1 1 1 2 3 3 3 3 Yeast mitochondrial distribution and morphology (MDM) proteins RRM_2 PF04059.12 ELR25356.1 - 4.2e-47 158.3 0.5 8.3e-47 157.3 0.5 1.5 1 0 0 1 1 1 1 RNA recognition motif 2 RRM_1 PF00076.22 ELR25356.1 - 1.2e-32 111.5 2.9 5.1e-15 55.1 0.2 3.4 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 ELR25356.1 - 4.6e-11 42.4 0.1 9.8e-09 34.9 0.0 2.4 1 1 1 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 ELR25356.1 - 3.4e-05 23.6 0.0 0.0021 17.9 0.0 2.5 2 0 0 2 2 2 1 Occluded RNA-recognition motif DbpA PF03880.15 ELR25356.1 - 0.00044 20.2 0.4 0.073 13.1 0.1 2.4 2 0 0 2 2 2 2 DbpA RNA binding domain PHM7_cyt PF14703.6 ELR25356.1 - 0.0058 16.9 0.3 25 5.0 0.0 4.2 4 1 1 5 5 5 1 Cytosolic domain of 10TM putative phosphate transporter BRAP2 PF07576.12 ELR25356.1 - 0.0068 16.6 1.6 0.013 15.7 0.1 2.2 3 0 0 3 3 3 1 BRCA1-associated protein 2 Ribosomal_L24e PF01246.20 ELR25357.1 - 4.5e-35 119.7 4.9 4.5e-35 119.7 4.9 1.8 2 0 0 2 2 2 1 Ribosomal protein L24e HscB_4_cys PF18256.1 ELR25357.1 - 0.04 13.7 0.2 0.09 12.6 0.2 1.6 1 0 0 1 1 1 0 Co-chaperone HscB tetracysteine metal binding motif zf-FCS PF06467.14 ELR25357.1 - 0.092 12.7 2.5 0.23 11.4 2.2 1.9 1 1 1 2 2 2 0 MYM-type Zinc finger with FCS sequence motif ABC2_membrane PF01061.24 ELR25358.1 - 3e-35 121.5 21.7 5.3e-35 120.7 21.7 1.4 1 0 0 1 1 1 1 ABC-2 type transporter ABC_tran PF00005.27 ELR25358.1 - 1.4e-26 93.6 0.0 2.7e-26 92.7 0.0 1.5 1 0 0 1 1 1 1 ABC transporter ABC2_membrane_3 PF12698.7 ELR25358.1 - 8.8e-09 34.9 8.1 1.2e-08 34.5 8.1 1.3 1 0 0 1 1 1 1 ABC-2 family transporter protein AAA_21 PF13304.6 ELR25358.1 - 1e-05 25.6 0.9 0.0064 16.3 0.1 2.3 1 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_25 PF13481.6 ELR25358.1 - 0.00031 20.4 0.0 0.0014 18.2 0.0 2.0 2 0 0 2 2 2 1 AAA domain SMC_N PF02463.19 ELR25358.1 - 0.00043 19.8 0.1 0.0022 17.5 0.1 1.9 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain RsgA_GTPase PF03193.16 ELR25358.1 - 0.0037 17.2 0.1 0.032 14.1 0.0 2.2 2 0 0 2 2 2 1 RsgA GTPase AAA_29 PF13555.6 ELR25358.1 - 0.006 16.3 0.0 0.013 15.3 0.0 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_28 PF13521.6 ELR25358.1 - 0.026 14.8 0.0 0.086 13.1 0.0 1.9 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 ELR25358.1 - 0.051 14.0 0.2 0.14 12.5 0.2 1.8 1 1 0 1 1 1 0 AAA ATPase domain AAA_18 PF13238.6 ELR25358.1 - 0.056 14.0 0.0 0.22 12.1 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_23 PF13476.6 ELR25358.1 - 0.12 12.8 0.0 0.26 11.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain BCS1_N PF08740.11 ELR25359.1 - 4.2e-36 124.7 0.8 4.2e-36 124.7 0.8 1.8 2 0 0 2 2 2 1 BCS1 N terminal AAA PF00004.29 ELR25359.1 - 4.2e-19 69.3 0.0 7.7e-19 68.4 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RNA_helicase PF00910.22 ELR25359.1 - 0.0018 18.7 0.0 0.004 17.5 0.0 1.7 1 1 0 1 1 1 1 RNA helicase DUF815 PF05673.13 ELR25359.1 - 0.0019 17.4 0.0 0.0047 16.1 0.0 1.6 1 1 0 1 1 1 1 Protein of unknown function (DUF815) AAA_5 PF07728.14 ELR25359.1 - 0.0039 17.2 0.0 0.11 12.5 0.0 2.5 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) RuvB_N PF05496.12 ELR25359.1 - 0.0078 16.0 0.0 0.015 15.1 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain ATPase PF06745.13 ELR25359.1 - 0.015 14.6 0.0 0.032 13.6 0.0 1.4 1 0 0 1 1 1 0 KaiC AAA_16 PF13191.6 ELR25359.1 - 0.016 15.6 0.7 0.061 13.7 0.7 2.2 1 1 0 1 1 1 0 AAA ATPase domain AAA_24 PF13479.6 ELR25359.1 - 0.022 14.5 0.1 0.27 11.0 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_33 PF13671.6 ELR25359.1 - 0.029 14.5 0.5 0.19 11.9 0.4 2.4 1 1 0 1 1 1 0 AAA domain ABC_tran PF00005.27 ELR25359.1 - 0.075 13.5 0.0 0.21 12.1 0.0 1.8 1 0 0 1 1 1 0 ABC transporter BACK PF07707.15 ELR25359.1 - 0.091 12.9 0.1 0.24 11.5 0.1 1.6 1 0 0 1 1 1 0 BTB And C-terminal Kelch Sigma54_activ_2 PF14532.6 ELR25359.1 - 0.14 12.3 0.0 0.26 11.4 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_25 PF13481.6 ELR25359.1 - 0.17 11.5 0.0 0.17 11.5 0.0 2.3 3 0 0 3 3 3 0 AAA domain V_ATPase_I PF01496.19 ELR25359.1 - 1.2 7.0 3.2 1.7 6.4 3.2 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Nop14 PF04147.12 ELR25360.1 - 5.3e-227 756.2 45.1 6.6e-227 755.9 45.1 1.0 1 0 0 1 1 1 1 Nop14-like family ORF6N PF10543.9 ELR25360.1 - 5.8 7.2 7.8 0.21 11.8 0.2 2.6 3 0 0 3 3 3 0 ORF6N domain 7tm_1 PF00001.21 ELR25361.1 - 5.4e-05 22.6 5.4 0.00018 21.0 2.3 2.6 2 1 1 3 3 3 1 7 transmembrane receptor (rhodopsin family) Peptidase_M48 PF01435.18 ELR25362.1 - 1.2e-35 123.1 0.2 1.6e-35 122.7 0.2 1.2 1 0 0 1 1 1 1 Peptidase family M48 Peptidase_M48_N PF16491.5 ELR25362.1 - 4.9e-16 59.1 10.5 4.9e-16 59.1 10.5 2.2 3 0 0 3 3 3 1 CAAX prenyl protease N-terminal, five membrane helices DUF2268 PF10026.9 ELR25362.1 - 0.024 14.2 0.1 0.047 13.3 0.1 1.4 1 0 0 1 1 1 0 Predicted Zn-dependent protease (DUF2268) SprT-like PF10263.9 ELR25362.1 - 0.035 14.0 0.2 0.061 13.2 0.2 1.3 1 0 0 1 1 1 0 SprT-like family Glyco_hydro_15 PF00723.21 ELR25363.1 - 0.00041 19.2 0.3 0.00049 19.0 0.3 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 15 Caskin-tail PF16632.5 ELR25363.1 - 0.13 12.6 3.0 0.18 12.2 0.0 2.4 2 1 1 3 3 3 0 C-terminal region of Caskin Macoilin PF09726.9 ELR25363.1 - 0.67 8.5 8.4 0.75 8.3 8.4 1.0 1 0 0 1 1 1 0 Macoilin family F-box-like PF12937.7 ELR25364.1 - 0.00016 21.5 1.2 0.00042 20.1 0.1 2.3 2 0 0 2 2 2 1 F-box-like G_glu_transpept PF01019.21 ELR25365.1 - 1.5e-142 476.0 0.1 9.1e-86 288.6 0.1 2.0 1 1 1 2 2 2 2 Gamma-glutamyltranspeptidase OppC_N PF12911.7 ELR25365.1 - 0.11 12.5 1.3 0.3 11.1 1.3 1.8 1 0 0 1 1 1 0 N-terminal TM domain of oligopeptide transport permease C LRR_6 PF13516.6 ELR25366.1 - 1.4e-25 87.1 47.3 0.0027 17.6 0.0 14.5 14 0 0 14 14 14 9 Leucine Rich repeat FERM_M PF00373.18 ELR25366.1 - 7.4e-20 71.5 0.0 2e-19 70.2 0.0 1.8 1 0 0 1 1 1 1 FERM central domain FERM_N PF09379.10 ELR25366.1 - 3.3e-07 30.1 0.0 9.5e-07 28.7 0.0 1.8 2 0 0 2 2 2 1 FERM N-terminal domain LRR_1 PF00560.33 ELR25366.1 - 8e-07 28.8 4.0 59 4.8 0.0 8.6 10 0 0 10 10 10 0 Leucine Rich Repeat LRR_4 PF12799.7 ELR25366.1 - 0.00014 22.1 23.6 0.6 10.6 0.3 7.4 7 0 0 7 7 7 3 Leucine Rich repeats (2 copies) SARAF PF06682.12 ELR25366.1 - 0.079 12.6 0.9 0.17 11.5 0.9 1.5 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis LRR_8 PF13855.6 ELR25366.1 - 0.17 11.7 21.2 3.9 7.3 0.2 7.8 8 2 0 8 8 8 0 Leucine rich repeat HATPase_c PF02518.26 ELR25367.1 - 2.4e-33 115.0 0.1 5.6e-33 113.8 0.1 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 ELR25367.1 - 3.7e-23 81.8 0.0 5.8e-14 52.2 0.0 2.5 2 0 0 2 2 2 2 Response regulator receiver domain HATPase_c_3 PF13589.6 ELR25367.1 - 6.9e-05 22.7 0.0 0.00018 21.3 0.0 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 ELR25367.1 - 0.00058 19.8 0.9 0.0048 16.9 0.2 2.3 1 1 1 2 2 2 1 His Kinase A (phospho-acceptor) domain HATPase_c_2 PF13581.6 ELR25367.1 - 0.069 13.1 0.0 0.22 11.5 0.0 1.8 1 0 0 1 1 1 0 Histidine kinase-like ATPase domain Com_YlbF PF06133.11 ELR25367.1 - 0.088 13.4 0.2 0.19 12.3 0.2 1.5 1 0 0 1 1 1 0 Control of competence regulator ComK, YlbF/YmcA PPP4R2 PF09184.11 ELR25367.1 - 2 8.0 6.1 3.4 7.2 6.1 1.3 1 0 0 1 1 1 0 PPP4R2 Alpha_kinase PF02816.18 ELR25368.1 - 2.2e-40 138.7 0.0 3.2e-40 138.2 0.0 1.2 1 0 0 1 1 1 1 Alpha-kinase family Trypsin_2 PF13365.6 ELR25368.1 - 7.2e-05 23.7 0.1 0.0002 22.3 0.1 1.8 1 0 0 1 1 1 1 Trypsin-like peptidase domain BCS1_N PF08740.11 ELR25369.1 - 2.8e-26 92.7 0.5 2.8e-26 92.7 0.5 2.2 2 1 1 3 3 3 1 BCS1 N terminal AAA PF00004.29 ELR25369.1 - 3.8e-19 69.4 0.0 6.6e-19 68.7 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DUF815 PF05673.13 ELR25369.1 - 0.00081 18.6 0.0 0.0023 17.1 0.0 1.7 1 1 0 1 1 1 1 Protein of unknown function (DUF815) RNA_helicase PF00910.22 ELR25369.1 - 0.0022 18.4 0.0 0.0057 17.0 0.0 1.8 1 1 0 1 1 1 1 RNA helicase RuvB_N PF05496.12 ELR25369.1 - 0.003 17.3 0.0 0.0059 16.4 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_5 PF07728.14 ELR25369.1 - 0.011 15.7 0.0 0.13 12.2 0.0 2.4 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) ATPase PF06745.13 ELR25369.1 - 0.013 14.8 0.0 0.03 13.7 0.0 1.5 1 0 0 1 1 1 0 KaiC AAA_16 PF13191.6 ELR25369.1 - 0.018 15.5 2.0 0.093 13.1 2.0 2.6 1 1 0 1 1 1 0 AAA ATPase domain AAA_33 PF13671.6 ELR25369.1 - 0.035 14.3 0.4 0.17 12.0 0.4 2.2 1 1 0 1 1 1 0 AAA domain AAA_18 PF13238.6 ELR25369.1 - 0.052 14.1 0.9 0.42 11.1 0.0 2.5 2 0 0 2 2 2 0 AAA domain Sigma54_activ_2 PF14532.6 ELR25369.1 - 0.063 13.4 0.0 0.12 12.5 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain ABC_tran PF00005.27 ELR25369.1 - 0.079 13.5 1.2 0.24 11.9 0.0 2.2 2 0 0 2 2 2 0 ABC transporter BACK PF07707.15 ELR25369.1 - 0.09 12.9 0.1 0.22 11.6 0.1 1.6 1 0 0 1 1 1 0 BTB And C-terminal Kelch AAA_25 PF13481.6 ELR25369.1 - 0.1 12.1 1.6 0.15 11.7 0.0 2.0 3 0 0 3 3 3 0 AAA domain NACHT PF05729.12 ELR25369.1 - 0.15 11.9 0.2 1.1 9.2 0.0 2.4 2 1 1 3 3 3 0 NACHT domain Lipase_3 PF01764.25 ELR25370.1 - 5.4e-27 94.4 0.0 4.6e-23 81.6 0.0 2.4 2 0 0 2 2 2 2 Lipase (class 3) Abhydrolase_5 PF12695.7 ELR25370.1 - 0.069 12.9 0.0 0.13 12.0 0.0 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase family Imm_superinfect PF14373.6 ELR25370.1 - 0.098 12.6 0.8 0.21 11.5 0.8 1.5 1 0 0 1 1 1 0 Superinfection immunity protein Abhydrolase_6 PF12697.7 ELR25370.1 - 0.11 13.0 0.0 0.23 12.0 0.0 1.6 1 0 0 1 1 1 0 Alpha/beta hydrolase family IQCJ-SCHIP1 PF15157.6 ELR25370.1 - 0.16 11.8 5.4 0.41 10.5 5.4 1.6 1 0 0 1 1 1 0 Fusion protein IQCJ-SCHIP1 with IQ-like motif DUF4834 PF16118.5 ELR25370.1 - 0.33 11.9 0.0 0.33 11.9 0.0 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4834) SR-25 PF10500.9 ELR25370.1 - 4.7 6.7 17.9 0.26 10.9 12.2 1.8 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein MORN PF02493.20 ELR25371.1 - 3e-60 196.6 59.7 1.1e-08 34.4 0.9 12.5 12 0 0 12 12 12 12 MORN repeat RINGv PF12906.7 ELR25372.1 - 1.3e-11 44.4 4.4 2.6e-11 43.5 4.4 1.5 1 0 0 1 1 1 1 RING-variant domain Ntox5 PF15543.6 ELR25373.1 - 0.12 12.2 0.0 0.17 11.7 0.0 1.4 1 1 0 1 1 1 0 Bacterial toxin 5 Filamin PF00630.19 ELR25374.1 - 0.00093 20.0 0.7 0.0015 19.4 0.1 1.6 2 0 0 2 2 2 1 Filamin/ABP280 repeat MORN PF02493.20 ELR25374.1 - 0.0017 18.2 12.9 1.1 9.3 0.6 4.7 5 0 0 5 5 5 3 MORN repeat Neurexophilin PF06312.12 ELR25374.1 - 0.02 14.3 0.0 0.027 13.9 0.0 1.2 1 0 0 1 1 1 0 Neurexophilin Retrotran_gag_2 PF14223.6 ELR25376.1 - 8.8e-15 54.6 0.0 1.6e-14 53.7 0.0 1.4 1 0 0 1 1 1 1 gag-polypeptide of LTR copia-type zf-CCHC PF00098.23 ELR25376.1 - 0.00029 20.8 1.9 0.00079 19.4 1.9 1.7 1 0 0 1 1 1 1 Zinc knuckle RVT_2 PF07727.14 ELR25377.1 - 6e-57 193.1 0.0 6.9e-57 192.9 0.0 1.0 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Piwi PF02171.17 ELR25380.1 - 0.034 13.4 0.1 0.038 13.2 0.1 1.2 1 0 0 1 1 1 0 Piwi domain NIF PF03031.18 ELR25382.1 - 2.6e-20 72.8 0.0 4.4e-20 72.0 0.0 1.3 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase Pentapeptide_4 PF13599.6 ELR25382.1 - 0.012 15.8 0.0 0.14 12.3 0.0 2.5 2 1 1 3 3 3 0 Pentapeptide repeats (9 copies) HAD PF12710.7 ELR25382.1 - 0.032 14.6 0.1 0.16 12.4 0.0 2.2 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase QVR PF17064.5 ELR25382.1 - 5.1 7.4 10.3 3.4 8.0 0.9 2.6 2 1 0 2 2 2 0 Sleepless protein DUF2428 PF10350.9 ELR25383.1 - 6.6e-16 58.4 0.0 1.4e-15 57.3 0.0 1.4 1 0 0 1 1 1 1 Putative death-receptor fusion protein (DUF2428) SH3_2 PF07653.17 ELR25383.1 - 2.2e-08 33.6 0.1 4.5e-08 32.6 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 ELR25383.1 - 2.8e-08 33.2 0.1 5.2e-08 32.4 0.1 1.4 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 ELR25383.1 - 3.1e-05 23.7 0.0 6.6e-05 22.7 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain RGS PF00615.19 ELR25384.1 - 8.4e-30 103.5 0.5 1.2e-29 103.0 0.5 1.2 1 0 0 1 1 1 1 Regulator of G protein signaling domain RGS PF00615.19 ELR25386.1 - 4.8e-30 104.3 0.6 6.8e-30 103.8 0.6 1.2 1 0 0 1 1 1 1 Regulator of G protein signaling domain 2Fe-2S_thioredx PF01257.19 ELR25387.1 - 9.9e-59 197.4 0.1 1.2e-58 197.0 0.1 1.1 1 0 0 1 1 1 1 Thioredoxin-like [2Fe-2S] ferredoxin PP2C PF00481.21 ELR25388.1 - 6.4e-57 193.1 0.1 2.7e-48 164.8 0.1 2.2 2 0 0 2 2 2 2 Protein phosphatase 2C ANAPC_CDC26 PF10471.9 ELR25388.1 - 6.3 7.7 10.5 2.6 9.0 5.9 2.4 2 0 0 2 2 2 0 Anaphase-promoting complex APC subunit CDC26 FAM178 PF14816.6 ELR25389.1 - 1.6e-05 24.1 6.4 3.5e-05 22.9 0.0 2.3 2 0 0 2 2 2 1 Family of unknown function, FAM178 HTH_9 PF08221.11 ELR25389.1 - 0.031 14.4 0.0 0.073 13.2 0.0 1.6 1 0 0 1 1 1 0 RNA polymerase III subunit RPC82 helix-turn-helix domain Red1 PF07964.11 ELR25389.1 - 2.3 6.3 26.7 3.2 5.9 26.7 1.1 1 0 0 1 1 1 0 Rec10 / Red1 Ferritin_2 PF13668.6 ELR25390.1 - 5.9e-35 120.4 0.1 5.9e-35 120.4 0.1 2.3 2 0 0 2 2 2 1 Ferritin-like domain FAD-oxidase_C PF02913.19 ELR25390.1 - 1.1 8.9 6.8 6.9 6.2 6.0 2.2 2 0 0 2 2 2 0 FAD linked oxidases, C-terminal domain Autophagy_act_C PF03987.15 ELR25391.1 - 1.2e-19 70.6 2.9 2.2e-19 69.8 2.9 1.4 1 0 0 1 1 1 1 Autophagocytosis associated protein, active-site domain DraK_HK_N PF18092.1 ELR25391.1 - 0.11 12.9 0.6 0.19 12.2 0.6 1.3 1 0 0 1 1 1 0 DraK Histidine Kinase N-terminal domain Cullin PF00888.22 ELR25392.1 - 1.5e-185 618.4 5.4 2e-185 618.0 5.4 1.1 1 0 0 1 1 1 1 Cullin family Cullin_Nedd8 PF10557.9 ELR25392.1 - 1.3e-29 102.0 2.1 3.6e-29 100.6 2.1 1.8 1 0 0 1 1 1 1 Cullin protein neddylation domain TrmB PF01978.19 ELR25392.1 - 0.0054 16.6 0.4 1.2 9.0 0.1 2.7 2 0 0 2 2 2 1 Sugar-specific transcriptional regulator TrmB Glycos_trans_3N PF02885.17 ELR25392.1 - 0.094 12.6 0.0 0.3 11.0 0.0 1.8 1 0 0 1 1 1 0 Glycosyl transferase family, helical bundle domain MarR_2 PF12802.7 ELR25392.1 - 0.098 12.6 0.0 0.38 10.7 0.0 1.9 2 0 0 2 2 2 0 MarR family HTH_27 PF13463.6 ELR25392.1 - 0.13 12.8 0.1 0.9 10.1 0.0 2.5 3 0 0 3 3 3 0 Winged helix DNA-binding domain Mad3_BUB1_I PF08311.12 ELR25392.1 - 0.82 9.7 3.5 25 4.8 0.0 3.9 4 1 0 4 4 4 0 Mad3/BUB1 homology region 1 Mrpl_C PF18502.1 ELR25392.1 - 6.1 7.2 6.1 19 5.6 0.2 3.3 4 0 0 4 4 4 0 54S ribosomal protein L8 C-terminal domain Forkhead PF00250.18 ELR25393.1 - 3.5e-06 27.2 0.0 6.9e-06 26.2 0.0 1.5 1 0 0 1 1 1 1 Forkhead domain HrpB2 PF09487.10 ELR25393.1 - 0.082 13.3 1.9 0.15 12.5 1.9 1.4 1 0 0 1 1 1 0 Bacterial type III secretion protein (HrpB2) MCM6_C PF18263.1 ELR25393.1 - 6.6 7.0 11.2 1.1 9.6 1.0 3.1 3 0 0 3 3 3 0 MCM6 C-terminal winged-helix domain RabGAP-TBC PF00566.18 ELR25394.1 - 1.8e-21 76.8 0.0 2.7e-21 76.2 0.0 1.2 1 0 0 1 1 1 1 Rab-GTPase-TBC domain zf-B_box PF00643.24 ELR25394.1 - 5.4e-05 23.2 5.7 9.5e-05 22.5 5.7 1.3 1 0 0 1 1 1 1 B-box zinc finger EcoEI_R_C PF08463.10 ELR25394.1 - 0.0069 16.5 0.3 0.016 15.3 0.1 1.7 2 0 0 2 2 2 1 EcoEI R protein C-terminal Cwf_Cwc_15 PF04889.12 ELR25394.1 - 0.22 11.2 4.3 0.39 10.4 4.3 1.4 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein ABC_tran PF00005.27 ELR25395.1 - 1.7e-50 171.1 0.5 6e-26 91.6 0.0 3.0 3 1 0 3 3 2 2 ABC transporter AAA_21 PF13304.6 ELR25395.1 - 2.5e-18 66.9 6.5 0.00018 21.5 0.1 4.3 2 2 1 4 4 4 4 AAA domain, putative AbiEii toxin, Type IV TA system ABC_tran_Xtn PF12848.7 ELR25395.1 - 6.9e-12 45.2 0.8 6.9e-12 45.2 0.8 3.2 4 0 0 4 4 2 1 ABC transporter SMC_N PF02463.19 ELR25395.1 - 1.2e-08 34.6 2.1 0.4 10.1 0.1 4.3 4 0 0 4 4 4 3 RecF/RecN/SMC N terminal domain AAA_18 PF13238.6 ELR25395.1 - 4.2e-06 27.3 1.7 0.064 13.8 0.0 3.8 3 2 1 4 4 3 2 AAA domain RsgA_GTPase PF03193.16 ELR25395.1 - 5.3e-06 26.4 0.0 0.022 14.7 0.0 2.6 2 0 0 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 ELR25395.1 - 3.4e-05 23.9 0.0 0.18 11.9 0.0 2.6 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_29 PF13555.6 ELR25395.1 - 4.5e-05 23.1 0.7 0.18 11.6 0.1 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_15 PF13175.6 ELR25395.1 - 0.00013 21.8 0.0 0.19 11.4 0.0 2.7 2 1 0 2 2 2 2 AAA ATPase domain AAA_16 PF13191.6 ELR25395.1 - 0.00022 21.6 1.6 1.2 9.5 1.8 2.8 2 1 0 2 2 2 2 AAA ATPase domain AAA_28 PF13521.6 ELR25395.1 - 0.00043 20.6 1.2 0.083 13.1 0.0 3.5 3 0 0 3 3 3 1 AAA domain AAA_27 PF13514.6 ELR25395.1 - 0.00092 18.9 0.1 0.7 9.5 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_24 PF13479.6 ELR25395.1 - 0.0015 18.3 0.5 3 7.5 0.0 3.3 3 0 0 3 3 3 1 AAA domain AAA_22 PF13401.6 ELR25395.1 - 0.0017 18.6 0.4 1.5 9.1 0.0 3.5 2 1 0 2 2 2 1 AAA domain Roc PF08477.13 ELR25395.1 - 0.0018 18.5 0.3 3.8 7.8 0.0 2.9 3 0 0 3 3 3 2 Ras of Complex, Roc, domain of DAPkinase NB-ARC PF00931.22 ELR25395.1 - 0.002 17.3 0.1 1.7 7.7 0.1 2.8 3 1 0 3 3 3 2 NB-ARC domain AAA_30 PF13604.6 ELR25395.1 - 0.0041 16.9 0.0 3.1 7.5 0.0 2.8 2 0 0 2 2 2 1 AAA domain AAA_13 PF13166.6 ELR25395.1 - 0.0074 15.0 6.6 0.77 8.3 0.0 3.9 4 0 0 4 4 4 1 AAA domain AAA_23 PF13476.6 ELR25395.1 - 0.0089 16.6 1.0 0.0089 16.6 1.0 4.2 2 2 0 2 2 1 1 AAA domain SbcCD_C PF13558.6 ELR25395.1 - 0.011 15.9 0.3 9.9 6.5 0.0 3.8 2 2 0 2 2 2 0 Putative exonuclease SbcCD, C subunit AAA PF00004.29 ELR25395.1 - 0.014 15.8 0.0 6 7.3 0.0 2.7 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) ATPase_2 PF01637.18 ELR25395.1 - 0.016 15.1 0.5 6.1 6.7 0.0 2.7 3 0 0 3 3 2 0 ATPase domain predominantly from Archaea cobW PF02492.19 ELR25395.1 - 0.016 14.8 0.2 0.44 10.1 0.1 2.3 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain KAP_NTPase PF07693.14 ELR25395.1 - 0.027 13.7 0.0 0.23 10.7 0.0 2.1 2 0 0 2 2 2 0 KAP family P-loop domain DLIC PF05783.11 ELR25395.1 - 0.045 12.6 0.1 7.5 5.3 0.0 2.3 2 0 0 2 2 2 0 Dynein light intermediate chain (DLIC) RNA_helicase PF00910.22 ELR25395.1 - 0.048 14.0 0.0 13 6.2 0.0 2.6 2 0 0 2 2 2 0 RNA helicase PduV-EutP PF10662.9 ELR25395.1 - 0.053 13.3 0.0 3.4 7.4 0.0 2.5 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation PRK PF00485.18 ELR25395.1 - 0.061 13.1 0.2 51 3.5 0.0 3.3 3 0 0 3 3 3 0 Phosphoribulokinase / Uridine kinase family NACHT PF05729.12 ELR25395.1 - 0.075 13.0 1.8 5.5 6.9 0.1 2.7 2 0 0 2 2 2 0 NACHT domain DUF463 PF04317.12 ELR25395.1 - 0.082 11.8 0.1 0.16 10.9 0.1 1.4 1 0 0 1 1 1 0 YcjX-like family, DUF463 Dynamin_N PF00350.23 ELR25395.1 - 0.11 12.5 7.4 0.61 10.1 0.1 3.2 3 2 0 3 3 3 0 Dynamin family AAA_25 PF13481.6 ELR25395.1 - 0.16 11.6 0.4 25 4.4 0.0 3.8 4 0 0 4 4 4 0 AAA domain ATP_bind_1 PF03029.17 ELR25395.1 - 0.36 10.6 1.3 9.5 5.9 0.0 2.7 3 0 0 3 3 2 0 Conserved hypothetical ATP binding protein AAA_33 PF13671.6 ELR25395.1 - 2 8.6 5.4 3 8.0 0.2 3.0 3 1 0 3 3 2 0 AAA domain Ras PF00071.22 ELR25396.1 - 3.6e-20 72.2 0.0 3.2e-19 69.1 0.0 2.0 1 1 1 2 2 2 1 Ras family Roc PF08477.13 ELR25396.1 - 0.00064 19.9 0.0 0.0017 18.6 0.0 1.7 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase F-box PF00646.33 ELR25396.1 - 0.0036 17.1 0.0 0.0064 16.4 0.0 1.4 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 ELR25396.1 - 0.0048 16.8 0.0 0.0081 16.0 0.0 1.4 1 0 0 1 1 1 1 F-box-like GTP_EFTU PF00009.27 ELR25396.1 - 0.014 15.0 0.0 0.017 14.7 0.0 1.2 1 0 0 1 1 1 0 Elongation factor Tu GTP binding domain PRANC PF09372.10 ELR25396.1 - 0.083 13.2 0.0 3.1 8.2 0.0 2.2 2 0 0 2 2 2 0 PRANC domain RhoGEF PF00621.20 ELR25397.1 - 8.7e-40 136.9 0.0 2.1e-39 135.7 0.0 1.7 1 0 0 1 1 1 1 RhoGEF domain PH_13 PF16652.5 ELR25397.1 - 2e-08 34.2 0.9 2e-08 34.2 0.9 3.1 2 1 0 2 2 2 1 Pleckstrin homology domain PH_4 PF15404.6 ELR25397.1 - 0.00013 21.9 0.4 0.00013 21.9 0.4 5.6 5 2 1 6 6 6 1 Pleckstrin homology domain PH PF00169.29 ELR25397.1 - 0.00014 22.3 0.3 0.00037 21.0 0.3 1.8 1 0 0 1 1 1 1 PH domain PH_10 PF15411.6 ELR25397.1 - 0.0012 19.1 0.2 0.0012 19.1 0.2 3.7 3 1 0 3 3 3 1 Pleckstrin homology domain PH_16 PF17838.1 ELR25397.1 - 0.0049 16.7 1.3 0.007 16.2 0.3 1.8 2 0 0 2 2 2 1 PH domain IQ PF00612.27 ELR25397.1 - 0.034 13.9 1.9 0.11 12.3 1.9 2.0 1 0 0 1 1 1 0 IQ calmodulin-binding motif Ribosomal_S17_N PF16205.5 ELR25398.1 - 4.9e-33 113.3 1.1 9.5e-33 112.4 1.1 1.5 1 0 0 1 1 1 1 Ribosomal_S17 N-terminal Ribosomal_S17 PF00366.20 ELR25398.1 - 7.3e-28 96.5 0.6 1.4e-27 95.6 0.6 1.5 1 0 0 1 1 1 1 Ribosomal protein S17 Cpn60_TCP1 PF00118.24 ELR25399.1 - 3e-156 520.9 6.4 3.6e-156 520.6 6.4 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Transket_pyr PF02779.24 ELR25400.1 - 2.1e-43 148.1 0.0 3e-43 147.6 0.0 1.2 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.20 ELR25400.1 - 8.5e-37 125.8 0.0 1.5e-36 125.0 0.0 1.4 1 0 0 1 1 1 1 Transketolase, C-terminal domain PFOR_II PF17147.4 ELR25400.1 - 0.087 13.1 0.0 0.15 12.4 0.0 1.4 1 0 0 1 1 1 0 Pyruvate:ferredoxin oxidoreductase core domain II Pkinase PF00069.25 ELR25401.1 - 9.7e-13 48.1 0.0 1.2e-12 47.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.23 ELR25401.1 - 4.3e-09 36.6 0.9 0.00029 20.9 0.0 2.2 1 1 1 2 2 2 2 Phosphotransferase enzyme family Pkinase_Tyr PF07714.17 ELR25401.1 - 1.1e-08 34.7 0.0 1.5e-08 34.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 ELR25401.1 - 5.7e-07 29.1 0.0 2.4e-06 27.1 0.0 1.9 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 ELR25401.1 - 2.9e-06 27.0 0.0 4.5e-06 26.4 0.0 1.4 1 1 0 1 1 1 1 RIO1 family EcKinase PF02958.20 ELR25401.1 - 0.016 14.5 0.0 0.022 14.1 0.0 1.2 1 0 0 1 1 1 0 Ecdysteroid kinase Choline_kinase PF01633.20 ELR25401.1 - 0.026 14.1 0.0 0.057 13.0 0.0 1.5 1 1 0 1 1 1 0 Choline/ethanolamine kinase Seadorna_VP7 PF07387.11 ELR25401.1 - 0.072 12.1 0.1 0.1 11.6 0.1 1.1 1 0 0 1 1 1 0 Seadornavirus VP7 Kinase-like PF14531.6 ELR25401.1 - 0.096 12.0 0.0 0.13 11.6 0.0 1.2 1 0 0 1 1 1 0 Kinase-like PI3_PI4_kinase PF00454.27 ELR25401.1 - 0.1 12.4 0.0 0.16 11.8 0.0 1.3 1 0 0 1 1 1 0 Phosphatidylinositol 3- and 4-kinase WaaY PF06176.11 ELR25401.1 - 0.13 11.8 0.0 0.17 11.5 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide core biosynthesis protein (WaaY) Pkinase_fungal PF17667.1 ELR25401.1 - 0.14 10.9 0.0 0.19 10.4 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase HEAT_2 PF13646.6 ELR25404.1 - 0.017 15.5 3.7 0.19 12.1 0.2 3.1 3 0 0 3 3 3 0 HEAT repeats DUF2428 PF10350.9 ELR25405.1 - 3.5e-19 69.1 0.0 4.9e-19 68.6 0.0 1.1 1 0 0 1 1 1 1 Putative death-receptor fusion protein (DUF2428) MyTH4 PF00784.17 ELR25405.1 - 0.0017 18.8 0.0 0.0066 16.9 0.0 2.0 2 1 0 2 2 2 1 MyTH4 domain PQ-loop PF04193.14 ELR25407.1 - 0.082 12.7 0.4 0.14 11.9 0.3 1.5 1 1 0 1 1 1 0 PQ loop repeat MORN PF02493.20 ELR25410.1 - 9.8e-19 66.1 44.9 0.00081 19.1 0.7 7.6 7 0 0 7 7 7 6 MORN repeat F-box-like PF12937.7 ELR25410.1 - 6.2e-14 51.6 0.6 1e-13 50.9 0.6 1.4 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ELR25410.1 - 7.6e-05 22.5 0.2 0.00012 21.8 0.2 1.3 1 0 0 1 1 1 1 F-box domain N_BRCA1_IG PF16158.5 ELR25412.1 - 3.3e-26 92.0 0.2 7.8e-26 90.8 0.2 1.7 1 0 0 1 1 1 1 Ig-like domain from next to BRCA1 gene PB1 PF00564.24 ELR25412.1 - 1.4e-14 53.8 0.2 4.4e-14 52.2 0.2 1.9 1 0 0 1 1 1 1 PB1 domain PRiA4_ORF3 PF07929.11 ELR25412.1 - 0.0095 15.6 2.2 0.079 12.7 0.0 2.8 2 1 0 2 2 2 1 Plasmid pRiA4b ORF-3-like protein WSD PF15613.6 ELR25413.1 - 1e-14 54.8 0.3 1e-14 54.8 0.3 3.4 3 1 0 3 3 3 1 Williams-Beuren syndrome DDT (WSD), D-TOX E motif DNMT1-RFD PF12047.8 ELR25413.1 - 2.8e-12 46.9 0.0 2.8e-12 46.9 0.0 2.9 4 0 0 4 4 4 1 Cytosine specific DNA methyltransferase replication foci domain zf-4CXXC_R1 PF10497.9 ELR25413.1 - 1.4e-05 25.2 13.3 1.4e-05 25.2 13.3 3.0 3 0 0 3 3 3 1 Zinc-finger domain of monoamine-oxidase A repressor R1 zf-C2HE PF16278.5 ELR25413.1 - 1.7 9.1 11.5 1.6 9.2 0.1 4.3 3 1 0 3 3 3 0 C2HE / C2H2 / C2HC zinc-binding finger zf-piccolo PF05715.13 ELR25413.1 - 4.8 7.4 14.4 0.1 12.7 6.9 2.2 2 0 0 2 2 2 0 Piccolo Zn-finger UCH PF00443.29 ELR25415.1 - 2.3e-52 178.1 0.0 3.3e-52 177.6 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP PF02148.19 ELR25415.1 - 4.4e-19 68.6 8.5 6.1e-19 68.1 4.2 2.8 2 0 0 2 2 2 1 Zn-finger in ubiquitin-hydrolases and other protein UCH_1 PF13423.6 ELR25415.1 - 1.1e-09 38.4 0.1 0.042 13.4 0.0 4.0 4 0 0 4 4 4 3 Ubiquitin carboxyl-terminal hydrolase zf-CCHC_3 PF13917.6 ELR25416.1 - 2.1e-05 24.4 0.1 2.1e-05 24.4 0.1 2.2 2 0 0 2 2 2 1 Zinc knuckle zf-CCHC PF00098.23 ELR25416.1 - 0.0024 17.9 2.3 0.0047 17.0 2.3 1.5 1 0 0 1 1 1 1 Zinc knuckle Kelch_5 PF13854.6 ELR25417.1 - 1.2e-13 50.7 13.1 0.00053 19.9 0.0 6.2 6 0 0 6 6 6 4 Kelch motif Kelch_6 PF13964.6 ELR25417.1 - 6.3e-13 48.5 8.7 0.00028 21.1 0.0 5.9 5 1 1 6 6 6 4 Kelch motif Kelch_3 PF13415.6 ELR25417.1 - 8.4e-07 29.1 4.1 0.0023 18.2 0.1 4.8 4 1 1 5 5 5 1 Galactose oxidase, central domain Kelch_4 PF13418.6 ELR25417.1 - 2.7e-06 27.3 10.7 0.06 13.4 0.0 5.7 6 0 0 6 6 6 2 Galactose oxidase, central domain Kelch_1 PF01344.25 ELR25417.1 - 3.1e-06 26.7 6.0 4.9e-05 22.8 0.0 4.7 5 1 0 5 5 5 1 Kelch motif Kelch_2 PF07646.15 ELR25417.1 - 0.0046 16.9 6.7 0.036 14.0 0.0 4.7 5 2 0 5 5 5 1 Kelch motif DUF4307 PF14155.6 ELR25417.1 - 0.31 10.9 1.7 5.2 7.0 0.3 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4307) FixQ PF05545.11 ELR25417.1 - 8.5 6.4 6.0 1.6 8.8 0.2 2.2 2 0 0 2 2 2 0 Cbb3-type cytochrome oxidase component FixQ Vps16_C PF04840.12 ELR25418.1 - 0.0082 15.2 0.2 0.0082 15.2 0.2 1.9 2 0 0 2 2 2 1 Vps16, C-terminal region DUF5361 PF17318.2 ELR25418.1 - 0.019 15.1 0.0 0.043 14.0 0.0 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5361) LppA PF16708.5 ELR25418.1 - 0.1 12.5 0.6 0.18 11.7 0.0 1.6 2 0 0 2 2 2 0 Lipoprotein confined to pathogenic Mycobacterium DUF4407 PF14362.6 ELR25418.1 - 0.12 11.7 2.2 2.9 7.1 0.4 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) CENP-Q PF13094.6 ELR25418.1 - 0.2 11.8 10.4 0.34 11.1 0.8 2.4 1 1 1 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit Baculo_F PF12259.8 ELR25418.1 - 0.24 9.9 2.8 0.38 9.2 2.8 1.2 1 0 0 1 1 1 0 Baculovirus F protein CENP-F_leu_zip PF10473.9 ELR25418.1 - 0.34 10.9 16.7 0.044 13.8 6.3 2.5 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF2353 PF09789.9 ELR25418.1 - 0.37 10.1 10.6 0.76 9.1 10.6 1.4 1 0 0 1 1 1 0 Uncharacterized coiled-coil protein (DUF2353) Seryl_tRNA_N PF02403.22 ELR25418.1 - 0.49 10.6 8.9 1.8 8.9 3.1 2.7 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain Med30 PF11315.8 ELR25418.1 - 0.89 9.7 9.1 0.23 11.7 1.1 2.3 2 0 0 2 2 2 0 Mediator complex subunit 30 Cep57_MT_bd PF06657.13 ELR25418.1 - 1.5 9.3 9.1 3.7 8.1 0.6 3.1 2 1 1 3 3 3 0 Centrosome microtubule-binding domain of Cep57 Tho2 PF11262.8 ELR25418.1 - 1.7 7.8 12.6 0.031 13.5 5.7 1.6 2 0 0 2 2 2 0 Transcription factor/nuclear export subunit protein 2 DUF2203 PF09969.9 ELR25418.1 - 3.8 8.3 7.9 0.36 11.5 0.3 2.7 2 1 1 3 3 3 0 Uncharacterized conserved protein (DUF2203) PCRF PF03462.18 ELR25418.1 - 8.3 6.2 10.2 0.51 10.2 3.4 2.0 2 0 0 2 2 2 0 PCRF domain ketoacyl-synt PF00109.26 ELR25419.1 - 2.4e-90 302.5 0.0 6e-90 301.2 0.0 1.7 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain AMP-binding PF00501.28 ELR25419.1 - 3.6e-82 276.2 0.0 5.8e-82 275.5 0.0 1.3 1 0 0 1 1 1 1 AMP-binding enzyme PS-DH PF14765.6 ELR25419.1 - 6.1e-64 216.1 0.1 1.5e-63 214.9 0.1 1.6 1 0 0 1 1 1 1 Polyketide synthase dehydratase Acyl_transf_1 PF00698.21 ELR25419.1 - 1.7e-63 215.1 0.7 6e-63 213.3 0.0 2.1 2 0 0 2 2 2 1 Acyl transferase domain KR PF08659.10 ELR25419.1 - 4.1e-57 193.0 0.1 8.7e-57 191.9 0.1 1.6 1 0 0 1 1 1 1 KR domain Ketoacyl-synt_C PF02801.22 ELR25419.1 - 1.4e-41 141.2 0.1 3.4e-39 133.5 0.0 3.2 3 0 0 3 3 3 1 Beta-ketoacyl synthase, C-terminal domain PP-binding PF00550.25 ELR25419.1 - 5.3e-23 81.1 1.8 2.5e-10 40.5 0.0 2.9 2 0 0 2 2 2 2 Phosphopantetheine attachment site Methyltransf_12 PF08242.12 ELR25419.1 - 6.4e-21 75.0 0.0 5e-20 72.1 0.0 2.6 2 0 0 2 2 1 1 Methyltransferase domain ADH_zinc_N_2 PF13602.6 ELR25419.1 - 1.7e-20 74.4 0.0 7.6e-20 72.3 0.0 2.2 1 0 0 1 1 1 1 Zinc-binding dehydrogenase KAsynt_C_assoc PF16197.5 ELR25419.1 - 1.6e-18 67.2 0.0 4e-18 65.9 0.0 1.7 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension ADH_zinc_N PF00107.26 ELR25419.1 - 2.5e-18 66.3 0.2 2.1e-17 63.3 0.0 2.8 3 0 0 3 3 1 1 Zinc-binding dehydrogenase Thioesterase PF00975.20 ELR25419.1 - 2.6e-17 63.7 0.1 1.5e-16 61.3 0.0 2.3 2 0 0 2 2 2 1 Thioesterase domain Methyltransf_25 PF13649.6 ELR25419.1 - 2.8e-14 53.6 0.0 1.3e-13 51.4 0.0 2.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ELR25419.1 - 1.2e-13 51.1 0.0 1.1e-12 48.0 0.0 2.4 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 ELR25419.1 - 1.5e-13 50.9 0.0 8.6e-13 48.5 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 ELR25419.1 - 1.9e-11 44.5 0.0 1.4e-10 41.6 0.0 2.5 2 0 0 2 2 2 1 Methyltransferase domain adh_short PF00106.25 ELR25419.1 - 2.6e-10 40.1 0.1 2e-09 37.2 0.0 2.2 2 0 0 2 2 2 1 short chain dehydrogenase ADH_N PF08240.12 ELR25419.1 - 2.5e-06 27.3 1.6 1.2e-05 25.1 0.9 2.3 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain Abhydrolase_6 PF12697.7 ELR25419.1 - 4.2e-06 27.5 1.1 4.2e-06 27.5 1.1 6.5 5 2 0 5 5 4 1 Alpha/beta hydrolase family Methyltransf_16 PF10294.9 ELR25419.1 - 4.2e-05 23.4 0.0 0.00021 21.1 0.0 2.0 2 0 0 2 2 2 1 Lysine methyltransferase Ubie_methyltran PF01209.18 ELR25419.1 - 4.6e-05 22.9 0.0 9.4e-05 21.9 0.0 1.4 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Thiolase_N PF00108.23 ELR25419.1 - 0.00059 19.3 0.0 0.0012 18.2 0.0 1.4 1 0 0 1 1 1 1 Thiolase, N-terminal domain Hydrolase_4 PF12146.8 ELR25419.1 - 0.0008 18.7 0.5 0.0036 16.6 0.1 2.2 2 1 0 2 2 2 1 Serine aminopeptidase, S33 NodS PF05401.11 ELR25419.1 - 0.00093 18.9 0.0 0.0021 17.7 0.0 1.5 1 0 0 1 1 1 1 Nodulation protein S (NodS) ACP_syn_III PF08545.10 ELR25419.1 - 0.0066 16.3 0.2 0.023 14.6 0.2 2.0 1 0 0 1 1 1 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III YjeF_N PF03853.15 ELR25419.1 - 0.0093 15.9 0.4 0.14 12.0 0.1 2.5 2 0 0 2 2 2 1 YjeF-related protein N-terminus Sacchrp_dh_NADP PF03435.18 ELR25419.1 - 0.012 15.8 0.0 0.16 12.2 0.0 2.9 3 0 0 3 3 2 0 Saccharopine dehydrogenase NADP binding domain Abhydrolase_1 PF00561.20 ELR25419.1 - 0.021 14.5 0.0 0.47 10.0 0.0 2.8 3 0 0 3 3 3 0 alpha/beta hydrolase fold RrnaAD PF00398.20 ELR25419.1 - 0.052 12.6 0.0 0.11 11.6 0.0 1.4 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase DUF2974 PF11187.8 ELR25419.1 - 0.055 13.0 0.0 0.18 11.3 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2974) FliD_N PF02465.18 ELR25419.1 - 0.12 13.0 2.2 9.4 7.0 0.7 2.7 2 0 0 2 2 2 0 Flagellar hook-associated protein 2 N-terminus 3Beta_HSD PF01073.19 ELR25419.1 - 0.13 11.2 0.0 1.3 8.0 0.0 2.2 2 0 0 2 2 2 0 3-beta hydroxysteroid dehydrogenase/isomerase family Lipase_GDSL_2 PF13472.6 ELR25420.1 - 5e-06 27.0 0.4 1.3e-05 25.7 0.4 1.6 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Pro-rich PF15240.6 ELR25421.1 - 0.011 16.0 8.1 0.012 16.0 8.1 1.0 1 0 0 1 1 1 0 Proline-rich NIF PF03031.18 ELR25424.1 - 0.00073 19.3 0.0 0.0013 18.6 0.0 1.3 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase DnaG_DnaB_bind PF08278.11 ELR25424.1 - 0.48 11.0 5.2 1 10.0 2.1 2.7 2 1 1 3 3 3 0 DNA primase DnaG DnaB-binding CNP1 PF08750.11 ELR25426.1 - 0.082 12.9 0.0 0.15 12.1 0.0 1.3 1 0 0 1 1 1 0 CNP1-like family Myb_DNA-binding PF00249.31 ELR25428.1 - 5.5e-38 128.9 17.3 1.1e-15 57.5 3.0 3.6 3 1 1 4 4 4 3 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 ELR25428.1 - 4.3e-27 94.1 4.0 1.2e-14 54.3 0.6 3.9 2 1 2 4 4 4 3 Myb-like DNA-binding domain Rap1_C PF11626.8 ELR25428.1 - 0.00082 19.4 4.5 0.11 12.7 0.5 2.7 1 1 1 2 2 2 2 TRF2-interacting telomeric protein/Rap1 - C terminal domain Myb_DNA-bind_7 PF15963.5 ELR25428.1 - 0.0016 18.3 0.1 0.65 9.9 0.4 2.8 1 1 2 3 3 3 1 Myb DNA-binding like SLIDE PF09111.10 ELR25428.1 - 0.097 12.7 0.0 12 6.0 0.0 2.3 1 1 1 2 2 2 0 SLIDE PBP1_TM PF14812.6 ELR25428.1 - 0.93 9.9 6.8 2.8 8.4 6.8 1.9 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal TFIIS_M PF07500.14 ELR25429.1 - 2.3e-33 115.0 3.0 3.9e-33 114.3 3.0 1.4 1 0 0 1 1 1 1 Transcription factor S-II (TFIIS), central domain TFIIS_C PF01096.18 ELR25429.1 - 2.6e-19 68.8 10.4 4.4e-19 68.1 10.4 1.4 1 0 0 1 1 1 1 Transcription factor S-II (TFIIS) DUF762 PF05555.11 ELR25429.1 - 0.01 15.5 0.1 2.1 7.9 0.0 2.1 1 1 1 2 2 2 2 Coxiella burnetii protein of unknown function (DUF762) DUF2250 PF10007.9 ELR25429.1 - 0.1 12.7 0.3 0.22 11.6 0.2 1.6 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2250) zf-DNL PF05180.12 ELR25429.1 - 0.48 10.4 4.8 1.1 9.3 4.8 1.6 1 0 0 1 1 1 0 DNL zinc finger C1_4 PF07975.12 ELR25429.1 - 1.9 8.8 10.3 3.9 7.8 4.5 2.7 1 1 1 2 2 2 0 TFIIH C1-like domain zinc_ribbon_4 PF13717.6 ELR25429.1 - 2.3 8.2 9.5 35 4.4 9.5 2.3 1 1 1 2 2 2 0 zinc-ribbon domain SUIM_assoc PF16619.5 ELR25430.1 - 0.028 14.5 1.7 0.24 11.5 0.5 2.4 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 Methyltransf_22 PF13383.6 ELR25430.1 - 0.058 13.0 0.5 0.088 12.4 0.5 1.2 1 0 0 1 1 1 0 Methyltransferase domain SelP_N PF04592.14 ELR25430.1 - 0.13 11.6 9.2 0.19 11.1 9.2 1.2 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Androgen_recep PF02166.16 ELR25430.1 - 0.46 9.3 5.8 0.64 8.8 5.8 1.1 1 0 0 1 1 1 0 Androgen receptor Vps51 PF08700.11 ELR25431.1 - 2.5e-27 94.8 2.3 2.5e-27 94.8 2.3 2.6 3 0 0 3 3 2 1 Vps51/Vps67 Sec5 PF15469.6 ELR25431.1 - 1.8e-16 60.5 0.2 1.4e-15 57.7 0.0 2.2 2 0 0 2 2 2 1 Exocyst complex component Sec5 Dor1 PF04124.12 ELR25431.1 - 4.5e-10 38.7 2.8 4.5e-10 38.7 2.8 2.1 2 0 0 2 2 2 1 Dor1-like family Vps54_N PF10475.9 ELR25431.1 - 8e-06 25.3 0.5 8e-06 25.3 0.5 1.6 2 0 0 2 2 2 1 Vacuolar-sorting protein 54, of GARP complex COG2 PF06148.11 ELR25431.1 - 3.8e-05 23.8 0.2 3.8e-05 23.8 0.2 2.8 3 0 0 3 3 3 1 COG (conserved oligomeric Golgi) complex component, COG2 COG5 PF10392.9 ELR25431.1 - 4.2e-05 23.7 1.1 4.2e-05 23.7 1.1 2.7 3 0 0 3 3 3 1 Golgi transport complex subunit 5 Vps53_N PF04100.12 ELR25431.1 - 0.0039 16.2 0.5 0.0082 15.2 0.5 1.4 1 0 0 1 1 1 1 Vps53-like, N-terminal Fib_alpha PF08702.10 ELR25431.1 - 0.033 14.4 2.0 0.92 9.7 0.3 2.8 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family SKA2 PF16740.5 ELR25431.1 - 0.1 12.4 4.7 0.44 10.3 0.7 3.3 3 1 0 3 3 3 0 Spindle and kinetochore-associated protein 2 Zw10 PF06248.13 ELR25431.1 - 0.12 10.9 1.7 0.17 10.4 0.5 1.7 2 0 0 2 2 2 0 Centromere/kinetochore Zw10 Cauli_AT PF03233.13 ELR25431.1 - 0.56 10.1 2.6 0.71 9.8 0.7 2.1 2 0 0 2 2 2 0 Aphid transmission protein Tweety PF04906.13 ELR25431.1 - 0.79 8.3 2.9 0.46 9.1 0.4 1.8 3 0 0 3 3 3 0 Tweety Laminin_II PF06009.12 ELR25431.1 - 1.1 9.2 5.6 1.3 9.1 0.7 2.7 3 0 0 3 3 3 0 Laminin Domain II Totivirus_coat PF05518.11 ELR25431.1 - 2.8 5.9 6.2 4.4 5.2 6.2 1.2 1 0 0 1 1 1 0 Totivirus coat protein Sof1 PF04158.14 ELR25432.1 - 1.1e-28 99.4 12.9 1.9e-28 98.6 12.9 1.4 1 0 0 1 1 1 1 Sof1-like domain WD40 PF00400.32 ELR25432.1 - 3.8e-19 68.7 10.1 0.00084 20.1 0.0 6.7 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ELR25432.1 - 0.0013 19.0 0.0 0.082 13.2 0.0 3.0 1 1 2 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain TGT PF01702.18 ELR25433.1 - 2.7e-73 247.1 0.0 3.5e-73 246.8 0.0 1.1 1 0 0 1 1 1 1 Queuine tRNA-ribosyltransferase SPA PF08616.10 ELR25434.1 - 7.8e-08 32.3 0.0 1.7e-07 31.2 0.0 1.5 1 0 0 1 1 1 1 Stabilization of polarity axis Avl9 PF09794.9 ELR25434.1 - 5.3e-05 22.1 0.0 0.076 11.7 0.0 2.1 1 1 1 2 2 2 2 Transport protein Avl9 DUF2347 PF09804.9 ELR25434.1 - 0.024 14.2 0.0 0.069 12.7 0.0 1.6 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2347) DUF2428 PF10350.9 ELR25435.1 - 7.8e-06 25.3 0.0 1.1e-05 24.9 0.0 1.2 1 0 0 1 1 1 1 Putative death-receptor fusion protein (DUF2428) Ank_2 PF12796.7 ELR25436.1 - 3.9e-84 277.3 29.3 8.5e-16 58.3 0.7 9.6 3 1 6 10 10 10 9 Ankyrin repeats (3 copies) Ank_5 PF13857.6 ELR25436.1 - 4.1e-75 246.9 37.9 7.5e-13 48.4 0.0 13.0 7 5 6 13 13 13 11 Ankyrin repeats (many copies) Ank_4 PF13637.6 ELR25436.1 - 1.3e-72 239.2 23.5 7.1e-12 45.6 0.4 13.5 6 4 8 14 14 14 14 Ankyrin repeats (many copies) Sec7 PF01369.20 ELR25436.1 - 1.9e-66 223.2 0.0 2.7e-66 222.8 0.0 1.2 1 0 0 1 1 1 1 Sec7 domain Ank PF00023.30 ELR25436.1 - 3.1e-59 195.0 52.5 1.7e-06 28.2 0.0 17.8 17 0 0 17 17 17 17 Ankyrin repeat Ank_3 PF13606.6 ELR25436.1 - 2.7e-53 171.7 27.4 0.0024 18.2 0.0 17.9 17 0 0 17 17 17 12 Ankyrin repeat PH PF00169.29 ELR25436.1 - 8.8e-15 55.1 0.0 2.8e-14 53.5 0.0 1.9 1 1 0 1 1 1 1 PH domain Lipase_3 PF01764.25 ELR25436.1 - 5.8e-07 29.5 0.0 1.2e-06 28.5 0.0 1.4 1 0 0 1 1 1 1 Lipase (class 3) PH_11 PF15413.6 ELR25436.1 - 9.4e-05 22.8 0.2 0.0006 20.2 0.0 2.1 2 0 0 2 2 2 1 Pleckstrin homology domain PH_8 PF15409.6 ELR25436.1 - 0.051 13.9 0.0 0.6 10.4 0.0 2.7 3 0 0 3 3 3 0 Pleckstrin homology domain PCI PF01399.27 ELR25437.1 - 2.4e-14 53.7 0.1 3.9e-14 53.0 0.1 1.2 1 0 0 1 1 1 1 PCI domain RPN6_C_helix PF18503.1 ELR25437.1 - 1.1e-12 47.5 0.0 1.8e-12 46.7 0.0 1.4 1 0 0 1 1 1 1 26S proteasome subunit RPN6 C-terminal helix domain DUF2428 PF10350.9 ELR25437.1 - 0.00024 20.5 0.0 0.00028 20.2 0.0 1.3 1 0 0 1 1 1 1 Putative death-receptor fusion protein (DUF2428) DDRGK PF09756.9 ELR25437.1 - 0.13 11.8 0.1 0.17 11.4 0.1 1.2 1 0 0 1 1 1 0 DDRGK domain Peptidase_C48 PF02902.19 ELR25438.1 - 2.6e-45 154.9 0.0 8.2e-45 153.3 0.0 1.9 1 1 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain DUF3682 PF12446.8 ELR25438.1 - 1.9 9.0 18.4 2 8.9 11.5 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3682) CENP-B_dimeris PF09026.10 ELR25438.1 - 2.5 8.6 10.2 0.54 10.7 0.4 2.6 2 0 0 2 2 2 0 Centromere protein B dimerisation domain HEAT_2 PF13646.6 ELR25439.1 - 0.29 11.5 4.3 0.37 11.2 0.2 2.8 3 0 0 3 3 3 0 HEAT repeats PS_Dcarbxylase PF02666.15 ELR25440.1 - 4.4e-49 166.8 0.0 3e-48 164.1 0.0 2.0 1 1 0 1 1 1 1 Phosphatidylserine decarboxylase C2 PF00168.30 ELR25440.1 - 1.1e-10 41.7 0.0 2.1e-10 40.8 0.0 1.4 1 0 0 1 1 1 1 C2 domain EF-hand_1 PF00036.32 ELR25440.1 - 2.2e-09 36.2 0.7 0.0018 17.7 0.2 2.7 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 ELR25440.1 - 3.2e-09 37.1 0.5 1e-08 35.5 0.5 1.9 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 ELR25440.1 - 3.5e-08 32.7 0.2 0.011 15.7 0.0 2.6 2 0 0 2 2 2 2 EF-hand domain GRAM PF02893.20 ELR25440.1 - 2e-07 30.9 0.0 5.6e-07 29.4 0.0 1.8 2 0 0 2 2 2 1 GRAM domain EF-hand_5 PF13202.6 ELR25440.1 - 1.7e-06 27.2 0.1 0.032 13.7 0.0 2.5 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 ELR25440.1 - 1.9e-05 24.4 3.7 0.00013 21.7 0.5 2.6 1 1 1 2 2 2 1 EF-hand domain pair zf-ribbon_3 PF13248.6 ELR25440.1 - 1.2 8.7 3.0 5.8 6.5 0.1 2.5 2 0 0 2 2 2 0 zinc-ribbon domain CTP_transf_like PF01467.26 ELR25441.1 - 3e-36 124.7 0.0 8.9e-21 74.6 0.0 2.2 2 0 0 2 2 2 2 Cytidylyltransferase-like Pantoate_ligase PF02569.15 ELR25441.1 - 0.029 13.6 0.0 4 6.6 0.0 2.3 2 0 0 2 2 2 0 Pantoate-beta-alanine ligase CPT PF07931.12 ELR25441.1 - 0.11 12.4 0.0 6.2 6.6 0.0 2.4 2 0 0 2 2 2 0 Chloramphenicol phosphotransferase-like protein Rhodanese PF00581.20 ELR25442.1 - 1.3e-16 61.0 0.0 2.5e-16 60.1 0.0 1.5 1 0 0 1 1 1 1 Rhodanese-like domain RlmM_FDX PF18125.1 ELR25442.1 - 0.13 12.8 0.0 0.92 10.0 0.0 2.1 2 0 0 2 2 2 0 RlmM ferredoxin-like domain TFIIA PF03153.13 ELR25443.1 - 0.099 12.6 31.6 0.15 12.0 31.6 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit CH PF00307.31 ELR25445.1 - 4.2e-15 55.9 3.5 7.1e-07 29.4 0.0 3.2 3 0 0 3 3 3 2 Calponin homology (CH) domain Focal_AT PF03623.13 ELR25445.1 - 0.38 10.7 4.5 3.1 7.8 2.4 2.9 2 0 0 2 2 2 0 Focal adhesion targeting region Clat_adaptor_s PF01217.20 ELR25446.1 - 3.2e-54 182.7 2.4 3.7e-54 182.5 2.4 1.0 1 0 0 1 1 1 1 Clathrin adaptor complex small chain DUF3114 PF11311.8 ELR25446.1 - 0.039 13.5 0.3 0.045 13.3 0.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3114) COPI_assoc PF08507.10 ELR25447.1 - 3.1e-09 37.0 12.8 4.3e-09 36.5 12.8 1.1 1 0 0 1 1 1 1 COPI associated protein EBP PF05241.12 ELR25447.1 - 0.21 11.0 6.0 0.12 11.8 1.3 2.1 1 1 0 2 2 2 0 Emopamil binding protein Peptidase_U4 PF03419.13 ELR25447.1 - 0.62 9.3 9.6 0.83 8.9 9.6 1.1 1 0 0 1 1 1 0 Sporulation factor SpoIIGA Homeodomain PF00046.29 ELR25448.1 - 3e-14 52.6 0.5 3e-14 52.6 0.5 2.0 2 0 0 2 2 2 1 Homeodomain Arf PF00025.21 ELR25449.1 - 2e-64 216.2 0.9 2.4e-64 216.0 0.9 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 ELR25449.1 - 2.6e-15 56.7 0.7 3.4e-15 56.3 0.7 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 ELR25449.1 - 1.2e-14 54.3 0.4 1.3e-14 54.1 0.4 1.1 1 0 0 1 1 1 1 Ras family SRPRB PF09439.10 ELR25449.1 - 3.2e-13 49.5 0.3 4.3e-13 49.1 0.3 1.0 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 ELR25449.1 - 9.7e-09 35.3 0.8 1.3e-08 34.9 0.8 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 ELR25449.1 - 2e-08 33.9 0.2 2.4e-08 33.6 0.2 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region G-alpha PF00503.20 ELR25449.1 - 2e-07 30.5 1.8 9.9e-06 24.9 0.4 2.5 1 1 1 2 2 2 1 G-protein alpha subunit GTP_EFTU PF00009.27 ELR25449.1 - 2e-05 24.2 1.3 0.0012 18.4 0.1 2.1 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain MeaB PF03308.16 ELR25449.1 - 0.0057 15.7 1.5 0.12 11.3 0.0 2.4 2 1 1 3 3 3 1 Methylmalonyl Co-A mutase-associated GTPase MeaB SRP54 PF00448.22 ELR25449.1 - 0.018 14.7 2.1 0.22 11.1 0.3 2.3 1 1 1 2 2 2 0 SRP54-type protein, GTPase domain ABC_tran PF00005.27 ELR25449.1 - 0.019 15.5 0.7 0.037 14.5 0.7 1.5 1 1 0 1 1 1 0 ABC transporter AAA_15 PF13175.6 ELR25449.1 - 0.03 14.0 0.0 0.037 13.7 0.0 1.2 1 1 0 1 1 1 0 AAA ATPase domain AAA_14 PF13173.6 ELR25449.1 - 0.091 12.8 0.1 0.22 11.5 0.0 1.6 1 1 1 2 2 2 0 AAA domain cobW PF02492.19 ELR25449.1 - 0.18 11.4 1.3 5.8 6.5 0.1 2.1 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Dynamin_N PF00350.23 ELR25449.1 - 0.23 11.5 1.0 11 6.0 0.2 2.1 1 1 0 2 2 2 0 Dynamin family CAF1 PF04857.20 ELR25450.1 - 7.9e-61 206.0 0.0 2e-59 201.4 0.0 2.6 2 1 0 2 2 2 1 CAF1 family ribonuclease RNA_bind PF08675.11 ELR25450.1 - 5.6e-15 55.1 0.0 9.7e-15 54.4 0.0 1.4 1 0 0 1 1 1 1 RNA binding domain NCBP3 PF10309.9 ELR25450.1 - 0.062 13.1 0.0 0.12 12.3 0.0 1.4 1 0 0 1 1 1 0 Nuclear cap-binding protein subunit 3 VIR_N PF15912.5 ELR25450.1 - 3.4 7.2 7.5 5.8 6.4 7.5 1.3 1 0 0 1 1 1 0 Virilizer, N-terminal OST3_OST6 PF04756.13 ELR25451.1 - 6.9e-12 45.3 0.3 7.8e-12 45.1 0.3 1.0 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family RIBIOP_C PF04950.12 ELR25452.1 - 1.1e-88 297.5 0.0 1.1e-88 297.5 0.0 2.6 3 0 0 3 3 2 1 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal AARP2CN PF08142.12 ELR25452.1 - 1.2e-28 99.0 0.0 9.8e-28 96.1 0.0 2.5 2 0 0 2 2 2 1 AARP2CN (NUC121) domain GTP_EFTU PF00009.27 ELR25452.1 - 2.8e-06 27.0 0.1 7.1e-05 22.4 0.0 2.6 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain AAA_16 PF13191.6 ELR25452.1 - 2.1e-05 25.0 0.1 0.00016 22.1 0.0 2.4 2 0 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 ELR25452.1 - 2.3e-05 24.7 0.0 7.8e-05 23.0 0.0 1.9 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 ELR25452.1 - 0.00011 22.3 0.1 0.00095 19.3 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA PF00004.29 ELR25452.1 - 0.00043 20.7 0.4 0.0017 18.8 0.0 2.2 3 0 0 3 3 2 1 ATPase family associated with various cellular activities (AAA) MMR_HSR1 PF01926.23 ELR25452.1 - 0.00068 19.7 0.2 0.0064 16.6 0.2 2.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_18 PF13238.6 ELR25452.1 - 0.0048 17.4 0.8 0.016 15.7 0.0 2.4 2 0 0 2 2 1 1 AAA domain AAA_25 PF13481.6 ELR25452.1 - 0.014 15.0 0.0 0.045 13.3 0.0 1.9 1 0 0 1 1 1 0 AAA domain AAA_5 PF07728.14 ELR25452.1 - 0.033 14.2 0.0 0.097 12.7 0.0 1.8 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) ABC_tran PF00005.27 ELR25452.1 - 0.038 14.5 0.0 0.038 14.5 0.0 2.2 2 0 0 2 2 2 0 ABC transporter AAA_19 PF13245.6 ELR25452.1 - 0.067 13.5 0.1 0.17 12.2 0.1 1.6 1 0 0 1 1 1 0 AAA domain ATP_bind_1 PF03029.17 ELR25452.1 - 0.089 12.6 0.1 0.2 11.4 0.1 1.6 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein RNA_helicase PF00910.22 ELR25452.1 - 0.11 12.9 0.0 0.27 11.6 0.0 1.7 1 0 0 1 1 1 0 RNA helicase PduV-EutP PF10662.9 ELR25452.1 - 0.14 11.9 0.0 0.32 10.7 0.0 1.6 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation NTPase_1 PF03266.15 ELR25452.1 - 0.6 10.0 3.4 0.17 11.8 0.2 1.7 2 0 0 2 2 1 0 NTPase Dynamin_N PF00350.23 ELR25452.1 - 2.5 8.1 5.8 6 6.9 0.0 3.3 2 1 1 3 3 3 0 Dynamin family Ank_2 PF12796.7 ELR25453.1 - 6.6e-24 84.3 0.6 1e-11 45.2 0.1 2.6 1 1 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ELR25453.1 - 1.4e-22 79.8 1.3 1.8e-09 37.9 0.1 5.0 2 2 3 5 5 5 5 Ankyrin repeats (many copies) Ank PF00023.30 ELR25453.1 - 4e-22 77.6 3.2 1.1e-06 28.8 0.0 4.7 4 0 0 4 4 4 4 Ankyrin repeat Ank_3 PF13606.6 ELR25453.1 - 5.2e-17 60.2 0.1 0.028 14.9 0.0 5.3 4 1 0 4 4 4 4 Ankyrin repeat Ank_5 PF13857.6 ELR25453.1 - 2.2e-11 43.8 0.5 0.00047 20.4 0.0 4.4 3 1 1 4 4 4 3 Ankyrin repeats (many copies) RNA_polI_A34 PF08208.11 ELR25453.1 - 3.8 7.5 25.9 0.022 14.8 16.5 2.1 2 0 0 2 2 2 0 DNA-directed RNA polymerase I subunit RPA34.5 Alpha-amylase PF00128.24 ELR25454.1 - 2e-62 211.7 0.0 6.4e-62 210.1 0.0 1.7 1 1 0 1 1 1 1 Alpha amylase, catalytic domain DUF1966 PF09260.11 ELR25454.1 - 2.5e-06 27.7 0.0 7.9e-06 26.1 0.0 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF1966) Glyco_hydro_70 PF02324.16 ELR25454.1 - 0.00016 20.0 0.0 0.057 11.6 0.0 2.2 2 0 0 2 2 2 2 Glycosyl hydrolase family 70 Aminotran_5 PF00266.19 ELR25454.1 - 0.028 13.4 0.0 0.047 12.6 0.0 1.2 1 0 0 1 1 1 0 Aminotransferase class-V DUF2838 PF10998.8 ELR25455.1 - 1.5e-34 118.6 13.2 1.5e-34 118.6 13.2 2.5 2 0 0 2 2 2 1 Protein of unknown function (DUF2838) DUF3899 PF13038.6 ELR25455.1 - 0.036 14.6 5.2 1.8 9.1 1.4 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF3899) FKBP_C PF00254.28 ELR25456.1 - 7.2e-32 109.6 0.0 1.1e-31 109.0 0.0 1.3 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase Acetyltransf_2 PF00797.17 ELR25458.1 - 2.8e-35 122.2 0.7 6e-26 91.7 0.1 3.0 2 1 1 3 3 3 3 N-acetyltransferase LSM PF01423.22 ELR25459.1 - 5.1e-19 67.7 1.2 6.3e-19 67.4 1.2 1.1 1 0 0 1 1 1 1 LSM domain BPL_C PF02237.17 ELR25459.1 - 0.004 17.0 0.6 0.0087 15.9 0.6 1.5 1 0 0 1 1 1 1 Biotin protein ligase C terminal domain Gemin7 PF11095.8 ELR25459.1 - 0.024 14.5 0.0 0.034 14.0 0.0 1.3 1 0 0 1 1 1 0 Gem-associated protein 7 (Gemin7) SM-ATX PF14438.6 ELR25459.1 - 0.048 13.8 0.1 0.064 13.4 0.1 1.2 1 0 0 1 1 1 0 Ataxin 2 SM domain IDH PF03971.14 ELR25459.1 - 0.24 9.8 0.1 0.28 9.6 0.1 1.0 1 0 0 1 1 1 0 Monomeric isocitrate dehydrogenase RAM PF15320.6 ELR25460.1 - 0.011 16.4 2.2 0.011 16.4 2.2 3.0 3 1 0 3 3 3 0 mRNA cap methylation, RNMT-activating mini protein PPR_2 PF13041.6 ELR25461.1 - 1.4e-08 34.8 1.7 0.0002 21.5 0.3 3.1 1 1 2 3 3 3 3 PPR repeat family PPR_3 PF13812.6 ELR25461.1 - 3.6e-07 30.1 0.5 0.0054 16.8 0.0 2.2 1 1 1 2 2 2 2 Pentatricopeptide repeat domain PPR_long PF17177.4 ELR25461.1 - 1.7e-05 24.3 0.0 2.3e-05 23.9 0.0 1.3 1 0 0 1 1 1 1 Pentacotripeptide-repeat region of PRORP PPR PF01535.20 ELR25461.1 - 0.014 15.6 1.6 8.9 6.8 0.1 3.2 3 0 0 3 3 3 0 PPR repeat TAF1_subA PF14929.6 ELR25461.1 - 0.028 13.8 0.2 0.032 13.7 0.2 1.1 1 0 0 1 1 1 0 TAF RNA Polymerase I subunit A Pkinase PF00069.25 ELR25462.1 - 0.13 11.6 0.3 0.23 10.8 0.3 1.3 1 0 0 1 1 1 0 Protein kinase domain PRP4 PF08799.11 ELR25463.1 - 0.14 11.7 1.0 0.22 11.1 1.0 1.3 1 0 0 1 1 1 0 pre-mRNA processing factor 4 (PRP4) like DUF3810 PF12725.7 ELR25464.1 - 0.034 13.5 0.0 0.059 12.7 0.0 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3810) Hydrolase_6 PF13344.6 ELR25464.1 - 0.042 14.0 0.0 0.089 12.9 0.0 1.5 1 1 0 1 1 1 0 Haloacid dehalogenase-like hydrolase Herpes_DNAp_acc PF04929.12 ELR25465.1 - 1.5 7.7 6.3 3.1 6.7 6.3 1.4 1 0 0 1 1 1 0 Herpes DNA replication accessory factor SPATA3 PF15662.5 ELR25465.1 - 8.7 6.9 11.1 15 6.1 1.9 2.7 2 1 1 3 3 3 0 Spermatogenesis-associated protein 3 family RhoGAP PF00620.27 ELR25466.1 - 2.7e-27 95.4 0.6 1.1e-13 51.3 0.4 2.5 1 1 1 2 2 2 2 RhoGAP domain GAGA_bind PF06217.12 ELR25466.1 - 0.13 12.5 7.9 0.3 11.3 2.0 2.4 2 0 0 2 2 2 0 GAGA binding protein-like family SR-25 PF10500.9 ELR25466.1 - 0.29 10.7 37.2 0.14 11.8 20.4 2.2 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein DUF3682 PF12446.8 ELR25466.1 - 0.43 11.1 18.3 0.028 14.9 4.3 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3682) Hamartin PF04388.12 ELR25466.1 - 0.9 8.1 12.7 0.0077 15.0 5.0 1.4 2 0 0 2 2 2 0 Hamartin protein Afi1 PF07792.12 ELR25466.1 - 0.99 9.9 8.9 4 7.9 3.5 2.4 2 0 0 2 2 2 0 Docking domain of Afi1 for Arf3 in vesicle trafficking RNA_polI_A34 PF08208.11 ELR25466.1 - 1.9 8.6 31.4 5.4 7.0 17.0 2.5 2 0 0 2 2 2 0 DNA-directed RNA polymerase I subunit RPA34.5 U1snRNP70_N PF12220.8 ELR25466.1 - 2.7 8.7 16.7 10 6.8 7.6 2.9 2 0 0 2 2 2 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal Peptidase_S49_N PF08496.10 ELR25466.1 - 5.6 7.0 15.2 9.3 6.3 0.0 2.4 2 0 0 2 2 2 0 Peptidase family S49 N-terminal Eapp_C PF10238.9 ELR25466.1 - 6.5 6.8 12.9 9.4 6.3 0.0 2.4 2 0 0 2 2 2 0 E2F-associated phosphoprotein RhoGEF PF00621.20 ELR25467.1 - 2.5e-49 168.0 0.6 1.7e-48 165.2 0.6 2.6 1 0 0 1 1 1 1 RhoGEF domain SBF2 PF12335.8 ELR25467.1 - 7.1e-08 32.3 0.2 7.1e-08 32.3 0.2 5.6 6 1 0 7 7 7 1 Myotubularin protein PH PF00169.29 ELR25467.1 - 5.8e-06 26.8 0.0 2.1e-05 25.0 0.0 2.0 1 0 0 1 1 1 1 PH domain Mucin PF01456.17 ELR25468.1 - 0.17 11.8 24.6 0.19 11.7 24.6 1.1 1 0 0 1 1 1 0 Mucin-like glycoprotein MGC-24 PF05283.11 ELR25468.1 - 0.35 11.3 10.6 0.42 11.1 10.6 1.0 1 0 0 1 1 1 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin MBOAT PF03062.19 ELR25469.1 - 1.8e-42 146.0 12.7 8.9e-42 143.7 12.4 2.0 1 1 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family ABC2_membrane PF01061.24 ELR25471.1 - 1.4e-39 135.7 15.3 1.9e-39 135.3 15.3 1.2 1 0 0 1 1 1 1 ABC-2 type transporter ABC_tran PF00005.27 ELR25471.1 - 7.9e-25 88.0 0.0 1.3e-24 87.3 0.0 1.4 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 ELR25471.1 - 3e-06 27.3 0.0 0.002 18.0 0.0 2.2 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system ABC2_membrane_3 PF12698.7 ELR25471.1 - 3.1e-05 23.3 14.0 4.4e-05 22.8 14.0 1.2 1 0 0 1 1 1 1 ABC-2 family transporter protein RsgA_GTPase PF03193.16 ELR25471.1 - 0.00082 19.3 0.0 0.0015 18.5 0.0 1.3 1 0 0 1 1 1 1 RsgA GTPase SMC_N PF02463.19 ELR25471.1 - 0.0094 15.4 0.0 1.1 8.7 0.0 2.2 2 0 0 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 ELR25471.1 - 0.04 14.3 0.0 0.077 13.4 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain AAA_25 PF13481.6 ELR25471.1 - 0.044 13.3 0.0 0.59 9.7 0.0 2.2 2 0 0 2 2 2 0 AAA domain SbcCD_C PF13558.6 ELR25471.1 - 0.048 13.9 0.0 0.2 11.9 0.0 2.0 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit MMR_HSR1 PF01926.23 ELR25471.1 - 0.1 12.7 0.1 0.23 11.5 0.1 1.6 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_24 PF13479.6 ELR25471.1 - 0.17 11.6 0.1 0.47 10.1 0.0 1.7 2 0 0 2 2 2 0 AAA domain Mito_carr PF00153.27 ELR25472.1 - 4e-69 228.6 0.2 6.6e-25 86.9 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 ELR25472.1 - 5.1e-05 22.6 0.0 0.93 8.6 0.0 3.1 3 0 0 3 3 3 2 Gammaproteobacterial serine protease G-alpha PF00503.20 ELR25473.1 - 1.5e-116 389.5 0.2 1.7e-116 389.3 0.2 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 ELR25473.1 - 3.6e-13 49.3 0.1 5.5e-09 35.7 0.0 2.3 2 0 0 2 2 2 2 ADP-ribosylation factor family Gtr1_RagA PF04670.12 ELR25473.1 - 0.01 15.2 0.7 3.6 6.9 0.0 2.4 2 0 0 2 2 2 0 Gtr1/RagA G protein conserved region AAA_29 PF13555.6 ELR25473.1 - 0.041 13.6 0.0 0.087 12.6 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain RE_CfrBI PF09516.10 ELR25473.1 - 0.069 12.6 0.0 0.12 11.8 0.0 1.3 1 0 0 1 1 1 0 CfrBI restriction endonuclease Glucosamine_iso PF01182.20 ELR25474.1 - 1.4e-53 182.1 0.0 1.8e-53 181.7 0.0 1.1 1 0 0 1 1 1 1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase RRM_1 PF00076.22 ELR25476.1 - 1.8e-07 30.9 0.0 2.5e-07 30.4 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DbpA PF03880.15 ELR25476.1 - 0.036 14.1 0.0 0.091 12.8 0.0 1.6 1 0 0 1 1 1 0 DbpA RNA binding domain LRR_8 PF13855.6 ELR25477.1 - 1.8e-28 98.1 54.7 8.9e-08 31.8 4.8 4.3 1 1 5 6 6 6 6 Leucine rich repeat LRR_4 PF12799.7 ELR25477.1 - 1.4e-19 69.8 26.0 4.7e-07 30.0 1.0 4.5 2 1 3 5 5 5 5 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 ELR25477.1 - 0.001 18.6 2.8 0.12 11.9 0.2 2.3 1 1 1 2 2 2 2 Leucine-rich repeat LRR_1 PF00560.33 ELR25477.1 - 0.0021 18.4 10.2 21 6.2 0.2 6.8 6 1 1 7 7 7 1 Leucine Rich Repeat CAP_N PF01213.19 ELR25477.1 - 0.066 12.7 0.0 0.066 12.7 0.0 2.4 2 0 0 2 2 2 0 Adenylate cyclase associated (CAP) N terminal HA PF03457.14 ELR25478.1 - 1.8e-07 31.4 0.9 3e-07 30.7 0.9 1.4 1 0 0 1 1 1 1 Helicase associated domain NUDIX PF00293.28 ELR25478.1 - 0.014 15.4 2.6 0.017 15.2 2.6 1.1 1 0 0 1 1 1 0 NUDIX domain HA PF03457.14 ELR25479.1 - 6e-05 23.3 2.8 0.00012 22.4 2.8 1.5 1 0 0 1 1 1 1 Helicase associated domain CCDC53 PF10152.9 ELR25479.1 - 3.3 8.1 8.1 12 6.3 1.7 2.2 2 0 0 2 2 2 0 Subunit CCDC53 of WASH complex HA PF03457.14 ELR25480.1 - 0.0035 17.6 5.6 0.0066 16.8 5.6 1.5 1 0 0 1 1 1 1 Helicase associated domain LRR_8 PF13855.6 ELR25480.1 - 0.0097 15.6 0.2 0.017 14.9 0.2 1.4 1 0 0 1 1 1 1 Leucine rich repeat LRR_4 PF12799.7 ELR25480.1 - 0.065 13.7 0.1 0.11 12.9 0.1 1.4 1 0 0 1 1 1 0 Leucine Rich repeats (2 copies) Nucleo_P87 PF07267.11 ELR25480.1 - 0.56 9.0 2.1 0.7 8.7 2.1 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 DUF2045 PF09741.9 ELR25481.1 - 2.6e-45 154.6 0.0 3.2e-45 154.4 0.0 1.1 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2045) BAT PF15915.5 ELR25482.1 - 0.03 14.2 0.0 0.054 13.4 0.0 1.4 1 0 0 1 1 1 0 GAF and HTH_10 associated domain NTP_transferase PF00483.23 ELR25483.1 - 9.3e-52 176.1 0.0 1.2e-51 175.7 0.0 1.2 1 0 0 1 1 1 1 Nucleotidyl transferase NTP_transf_3 PF12804.7 ELR25483.1 - 4.8e-10 40.0 0.0 6e-10 39.7 0.0 1.2 1 0 0 1 1 1 1 MobA-like NTP transferase domain Hexapep PF00132.24 ELR25483.1 - 7.4e-10 38.2 7.8 1.2e-08 34.3 1.8 3.6 1 1 2 3 3 3 1 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 ELR25483.1 - 0.00044 20.0 4.8 0.00044 20.0 4.8 3.5 4 1 0 4 4 4 1 Hexapeptide repeat of succinyl-transferase GH3 PF03321.13 ELR25484.1 - 1.3e-113 380.7 0.0 1.2e-112 377.5 0.0 1.9 1 1 0 1 1 1 1 GH3 auxin-responsive promoter DUF3439 PF11921.8 ELR25485.1 - 1.9 8.5 6.9 1.8 8.5 6.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) Trypsin_2 PF13365.6 ELR25486.1 - 1.3e-30 107.2 2.9 1.4e-26 94.2 0.7 2.7 3 0 0 3 3 3 2 Trypsin-like peptidase domain Trypsin PF00089.26 ELR25486.1 - 1.3e-12 48.0 0.1 4.1e-12 46.4 0.1 1.7 1 1 0 1 1 1 1 Trypsin Peptidase_S46 PF10459.9 ELR25486.1 - 0.064 11.9 2.8 4.9 5.7 0.7 2.7 3 0 0 3 3 3 0 Peptidase S46 Histone PF00125.24 ELR25487.1 - 1.9e-20 73.5 0.3 1.9e-20 73.5 0.3 2.1 1 1 1 2 2 2 1 Core histone H2A/H2B/H3/H4 SR-25 PF10500.9 ELR25487.1 - 0.13 11.8 6.7 0.17 11.5 6.7 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein CN_hydrolase PF00795.22 ELR25488.1 - 3.2e-45 154.5 0.1 4.8e-45 153.9 0.1 1.3 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase RasGEF PF00617.19 ELR25489.1 - 2.9e-55 187.2 0.1 8e-55 185.8 0.1 1.8 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 ELR25489.1 - 2.8e-29 101.4 0.2 8e-29 100.0 0.2 1.8 1 0 0 1 1 1 1 RasGEF N-terminal motif Ras PF00071.22 ELR25489.1 - 1.3e-06 28.1 0.0 3.7e-06 26.6 0.0 1.7 1 1 0 1 1 1 1 Ras family FIT1_2 PF17357.2 ELR25489.1 - 2.9 8.0 5.3 1.6 8.9 1.4 2.4 3 0 0 3 3 3 0 Facilitor Of iron transport 1 and 2 Yippee-Mis18 PF03226.14 ELR25490.1 - 7.2e-16 58.3 0.2 8.1e-16 58.1 0.2 1.1 1 0 0 1 1 1 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly SelR PF01641.18 ELR25490.1 - 0.00012 22.1 0.4 0.00016 21.8 0.4 1.2 1 0 0 1 1 1 1 SelR domain RIG-I_C-RD PF11648.8 ELR25490.1 - 0.035 14.3 0.6 0.046 13.9 0.6 1.3 1 0 0 1 1 1 0 C-terminal domain of RIG-I Longin PF13774.6 ELR25491.1 - 1.9e-09 37.4 0.0 3.2e-09 36.7 0.0 1.3 1 0 0 1 1 1 1 Regulated-SNARE-like domain UCH PF00443.29 ELR25492.1 - 5.9e-41 140.7 3.8 3.7e-28 98.7 0.0 3.1 2 2 1 3 3 3 2 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 ELR25492.1 - 5.2e-25 88.7 0.2 5.7e-15 55.7 0.0 3.3 2 1 1 3 3 3 2 Ubiquitin carboxyl-terminal hydrolase SEC-C PF02810.15 ELR25492.1 - 1.1e-09 38.0 5.7 2e-09 37.2 5.7 1.4 1 0 0 1 1 1 1 SEC-C motif zinc_ribbon_12 PF11331.8 ELR25492.1 - 0.45 10.4 13.1 0.33 10.8 0.2 3.6 3 0 0 3 3 3 0 Probable zinc-ribbon domain 2-oxoacid_dh PF00198.23 ELR25493.1 - 1.3e-81 273.4 0.0 2.5e-81 272.6 0.0 1.4 2 0 0 2 2 2 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.22 ELR25493.1 - 1.8e-18 66.1 0.0 3.9e-18 65.0 0.0 1.6 1 0 0 1 1 1 1 Biotin-requiring enzyme E3_binding PF02817.17 ELR25493.1 - 3.8e-17 62.3 1.3 2.9e-16 59.5 0.5 2.6 2 0 0 2 2 2 1 e3 binding domain RnfC_N PF13375.6 ELR25493.1 - 0.063 13.2 0.0 0.18 11.8 0.0 1.7 1 0 0 1 1 1 0 RnfC Barrel sandwich hybrid domain Biotin_lipoyl_2 PF13533.6 ELR25493.1 - 0.079 12.8 0.0 1.6 8.6 0.0 2.6 2 1 1 3 3 3 0 Biotin-lipoyl like DUF1645 PF07816.11 ELR25493.1 - 0.087 13.4 3.6 0.13 12.8 3.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1645) SR-25 PF10500.9 ELR25493.1 - 1.5 8.4 13.8 2.3 7.8 13.8 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein zf-RING_UBOX PF13445.6 ELR25494.1 - 4.4e-06 26.6 3.6 4.8e-06 26.5 2.2 1.8 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4_4 PF15227.6 ELR25494.1 - 6.3e-06 26.2 5.5 1.3e-05 25.2 5.5 1.6 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-C3HC4 PF00097.25 ELR25494.1 - 1.5e-05 24.7 2.4 2.9e-05 23.8 2.4 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ELR25494.1 - 0.00084 19.3 4.7 0.0016 18.4 4.7 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 ELR25494.1 - 0.0024 17.7 3.3 0.0048 16.7 3.3 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 ELR25494.1 - 0.0028 17.5 4.6 0.0061 16.4 4.6 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 ELR25494.1 - 0.025 14.9 3.4 0.058 13.7 3.4 1.7 1 0 0 1 1 1 0 Ring finger domain Prok-RING_4 PF14447.6 ELR25494.1 - 0.027 14.4 1.3 0.061 13.2 1.3 1.6 1 1 0 1 1 1 0 Prokaryotic RING finger family 4 zf-RING_6 PF14835.6 ELR25494.1 - 0.2 11.5 6.4 0.57 10.1 4.5 2.3 2 0 0 2 2 2 0 zf-RING of BARD1-type protein PPR_long PF17177.4 ELR25495.1 - 3.1e-07 30.0 0.9 8e-07 28.6 0.0 1.9 2 0 0 2 2 2 1 Pentacotripeptide-repeat region of PRORP PPR_2 PF13041.6 ELR25495.1 - 0.0004 20.5 0.0 0.0095 16.1 0.0 2.5 2 0 0 2 2 2 1 PPR repeat family PPR_3 PF13812.6 ELR25495.1 - 0.0083 16.2 0.0 1.9 8.6 0.0 2.5 1 1 1 2 2 2 2 Pentatricopeptide repeat domain PPR PF01535.20 ELR25495.1 - 0.02 15.1 0.0 2.5 8.5 0.0 3.3 3 0 0 3 3 3 0 PPR repeat EF-hand_9 PF14658.6 ELR25495.1 - 0.079 13.3 0.1 0.39 11.1 0.0 2.1 3 0 0 3 3 3 0 EF-hand domain DUF4667 PF15700.5 ELR25496.1 - 0.002 18.3 3.1 0.0025 18.0 3.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4667) SR-25 PF10500.9 ELR25496.1 - 0.014 15.0 13.8 0.014 15.0 13.8 1.9 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein Ras PF00071.22 ELR25497.1 - 2.5e-36 124.7 0.5 7.4e-23 80.9 0.1 2.0 1 1 1 2 2 2 2 Ras family Roc PF08477.13 ELR25497.1 - 3.5e-15 56.3 1.4 2.5e-09 37.4 0.1 2.2 1 1 1 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase RsgA_GTPase PF03193.16 ELR25497.1 - 1.3e-07 31.6 0.3 0.0064 16.4 0.2 2.1 2 0 0 2 2 2 2 RsgA GTPase Arf PF00025.21 ELR25497.1 - 0.00042 19.8 0.1 0.25 10.8 0.1 2.1 1 1 1 2 2 2 2 ADP-ribosylation factor family AAA_7 PF12775.7 ELR25497.1 - 0.0042 16.6 0.0 0.0073 15.8 0.0 1.3 1 0 0 1 1 1 1 P-loop containing dynein motor region MMR_HSR1 PF01926.23 ELR25497.1 - 0.0073 16.4 0.1 0.019 15.0 0.1 1.7 1 1 0 1 1 1 1 50S ribosome-binding GTPase PduV-EutP PF10662.9 ELR25497.1 - 0.008 15.9 0.0 0.011 15.4 0.0 1.3 1 0 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation NACHT PF05729.12 ELR25497.1 - 0.051 13.5 0.1 0.086 12.7 0.1 1.4 1 0 0 1 1 1 0 NACHT domain AAA_16 PF13191.6 ELR25497.1 - 0.061 13.7 0.0 0.076 13.4 0.0 1.2 1 0 0 1 1 1 0 AAA ATPase domain Septin PF00735.18 ELR25497.1 - 0.063 12.5 0.0 0.089 12.1 0.0 1.2 1 0 0 1 1 1 0 Septin SRPRB PF09439.10 ELR25497.1 - 0.076 12.4 0.1 0.15 11.5 0.1 1.4 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit DUF815 PF05673.13 ELR25497.1 - 0.093 11.9 0.0 0.15 11.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_25 PF13481.6 ELR25497.1 - 0.11 12.0 0.0 0.19 11.3 0.0 1.4 1 1 0 1 1 1 0 AAA domain Lipase_3 PF01764.25 ELR25498.1 - 1.5e-17 63.8 0.0 2.6e-12 46.8 0.0 3.2 3 0 0 3 3 3 2 Lipase (class 3) Abhydrolase_1 PF00561.20 ELR25498.1 - 0.057 13.1 0.0 0.1 12.2 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 ELR25498.1 - 0.066 12.5 0.0 0.14 11.4 0.0 1.5 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Abhydrolase_5 PF12695.7 ELR25498.1 - 0.11 12.2 0.0 0.21 11.3 0.0 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase family Pkinase_Tyr PF07714.17 ELR25499.1 - 4.4e-45 154.0 0.0 3.4e-43 147.8 0.0 2.2 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ELR25499.1 - 2.5e-36 125.4 0.0 4.7e-34 117.9 0.0 2.3 1 1 0 1 1 1 1 Protein kinase domain SR-25 PF10500.9 ELR25500.1 - 0.36 10.4 14.1 0.45 10.1 14.1 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein RAP1 PF07218.11 ELR25500.1 - 1.3 7.2 4.3 1.5 7.0 4.3 1.0 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) DUF4551 PF15087.6 ELR25500.1 - 3.8 6.2 5.0 4.3 6.1 5.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) Malic_M PF03949.15 ELR25501.1 - 7.2e-102 340.1 0.1 9.5e-102 339.7 0.1 1.1 1 0 0 1 1 1 1 Malic enzyme, NAD binding domain malic PF00390.19 ELR25501.1 - 1.3e-75 253.2 0.0 2.1e-75 252.5 0.0 1.4 1 0 0 1 1 1 1 Malic enzyme, N-terminal domain Diphthamide_syn PF01866.17 ELR25502.1 - 3e-97 325.7 0.0 1.5e-96 323.4 0.0 1.8 1 1 0 1 1 1 1 Putative diphthamide synthesis protein DUF2400 PF09674.10 ELR25502.1 - 0.074 13.0 0.0 0.11 12.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2400) Peptidase_A22B PF04258.13 ELR25504.1 - 5e-91 305.1 14.2 7.7e-91 304.5 14.2 1.2 1 0 0 1 1 1 1 Signal peptide peptidase Neur_chan_memb PF02932.16 ELR25504.1 - 0.057 13.5 1.9 0.089 12.8 1.9 1.4 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DENN PF02141.21 ELR25505.1 - 8.6e-24 84.5 1.7 4.4e-21 75.7 0.4 2.5 2 0 0 2 2 2 2 DENN (AEX-3) domain uDENN PF03456.18 ELR25505.1 - 1.3e-05 25.8 1.0 7.1e-05 23.5 0.1 2.5 2 0 0 2 2 2 1 uDENN domain dDENN PF03455.19 ELR25505.1 - 0.007 16.3 1.0 0.015 15.3 1.0 1.6 1 0 0 1 1 1 1 dDENN domain VasL PF12486.8 ELR25505.1 - 0.52 10.2 6.8 0.21 11.4 4.0 1.7 2 0 0 2 2 2 0 Type VI secretion system, EvfB, or VasL APG6_N PF17675.1 ELR25505.1 - 2.5 8.6 6.8 0.61 10.6 3.0 1.9 2 0 0 2 2 2 0 Apg6 coiled-coil region LETM1 PF07766.13 ELR25507.1 - 8.4e-41 140.1 0.0 1e-26 93.9 0.0 2.0 2 0 0 2 2 2 2 LETM1-like protein SAP PF02037.27 ELR25507.1 - 0.0008 19.1 0.1 14 5.6 0.0 3.5 3 0 0 3 3 3 3 SAP domain MIG-14_Wnt-bd PF06664.12 ELR25508.1 - 0.0027 17.0 5.5 0.0033 16.7 5.5 1.1 1 0 0 1 1 1 1 Wnt-binding factor required for Wnt secretion DUF3464 PF11947.8 ELR25508.1 - 0.065 13.0 0.4 0.15 11.8 0.3 1.6 2 0 0 2 2 2 0 Photosynthesis affected mutant 68 CPP1-like PF11833.8 ELR25508.1 - 0.45 10.1 1.8 0.62 9.7 1.8 1.3 1 0 0 1 1 1 0 Protein CHAPERONE-LIKE PROTEIN OF POR1-like DUF4094 PF13334.6 ELR25508.1 - 3.9 7.9 5.1 1.3 9.4 1.3 2.1 2 1 0 2 2 2 0 Domain of unknown function (DUF4094) RseC_MucC PF04246.12 ELR25508.1 - 7.5 6.5 6.9 0.88 9.5 1.9 1.9 2 0 0 2 2 2 0 Positive regulator of sigma(E), RseC/MucC CCDC23 PF15674.5 ELR25509.1 - 0.00012 22.0 3.8 1e+02 3.0 0.0 5.8 1 1 5 6 6 6 0 Coiled-coil domain-containing protein 23 TB PF00683.17 ELR25509.1 - 0.0024 17.6 10.9 39 4.1 0.2 6.1 2 2 2 6 6 6 2 TB domain DUF4194 PF13835.6 ELR25509.1 - 0.3 10.8 9.3 74 3.0 0.0 5.1 1 1 5 6 6 6 0 Domain of unknown function (DUF4194) NGF PF00243.18 ELR25509.1 - 1.8 8.8 7.2 13 6.1 0.6 3.1 1 1 3 4 4 4 0 Nerve growth factor family Metallophos PF00149.28 ELR25510.1 - 4e-09 37.3 0.2 6.1e-09 36.7 0.2 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase MSP1a PF11670.8 ELR25510.1 - 0.15 11.4 0.8 0.24 10.7 0.8 1.3 1 0 0 1 1 1 0 Major surface protein 1a (MSP1a) Glycos_transf_2 PF00535.26 ELR25511.1 - 7.1e-25 87.8 0.0 9.3e-25 87.4 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 ELR25511.1 - 1.1e-06 28.7 0.5 1.6e-06 28.2 0.1 1.5 2 0 0 2 2 2 1 Glycosyltransferase like family 2 Glyco_transf_7C PF02709.14 ELR25511.1 - 0.037 13.7 0.0 0.079 12.6 0.0 1.5 1 0 0 1 1 1 0 N-terminal domain of galactosyltransferase Glyco_tranf_2_2 PF10111.9 ELR25511.1 - 0.095 12.2 0.0 0.14 11.6 0.0 1.3 1 0 0 1 1 1 0 Glycosyltransferase like family 2 PSS PF03034.15 ELR25512.1 - 3.3e-94 315.7 19.4 3.3e-94 315.7 19.4 1.9 2 1 0 2 2 2 1 Phosphatidyl serine synthase Deltaretro_Tax PF05599.11 ELR25512.1 - 0.92 10.1 6.2 0.17 12.4 0.4 2.6 2 0 0 2 2 2 0 Deltaretrovirus Tax protein MRP-L27 PF09809.9 ELR25514.1 - 5.5e-12 45.5 0.2 7.1e-12 45.2 0.2 1.2 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L27 DUF1236 PF06823.12 ELR25514.1 - 0.023 14.6 0.1 0.033 14.1 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1236) XRCC4 PF06632.12 ELR25515.1 - 7.1e-17 61.3 3.2 9.7e-17 60.8 3.2 1.3 1 0 0 1 1 1 1 DNA double-strand break repair and V(D)J recombination protein XRCC4 SHE3 PF17078.5 ELR25515.1 - 0.0044 16.8 2.2 0.0096 15.7 1.9 1.7 2 0 0 2 2 2 1 SWI5-dependent HO expression protein 3 ZapB PF06005.12 ELR25515.1 - 0.33 11.4 7.3 0.18 12.2 4.1 2.1 1 1 1 2 2 2 0 Cell division protein ZapB JIP_LZII PF16471.5 ELR25515.1 - 1.6 9.0 6.5 3.7 7.8 6.5 1.6 1 0 0 1 1 1 0 JNK-interacting protein leucine zipper II Peptidase_M54 PF07998.11 ELR25516.1 - 0.099 12.6 0.9 0.15 12.1 0.9 1.3 1 0 0 1 1 1 0 Peptidase family M54 DUF4298 PF14131.6 ELR25516.1 - 0.13 12.2 0.1 0.21 11.6 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4298) CsbD PF05532.12 ELR25518.1 - 0.04 13.8 1.1 0.07 13.0 1.1 1.3 1 0 0 1 1 1 0 CsbD-like Mt_ATP-synt_B PF05405.14 ELR25519.1 - 0.49 10.0 7.5 3.3 7.3 3.5 2.1 2 0 0 2 2 2 0 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) TetR_C_11 PF16859.5 ELR25519.1 - 0.85 9.9 6.1 0.99 9.7 4.8 1.7 1 1 1 2 2 2 0 Tetracyclin repressor-like, C-terminal domain DUF4050 PF13259.6 ELR25519.1 - 0.96 9.7 10.0 1.1 9.5 10.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4050) LRR_6 PF13516.6 ELR25520.1 - 4.8e-23 79.2 17.1 0.013 15.5 0.0 10.8 11 0 0 11 11 11 6 Leucine Rich repeat LRR_4 PF12799.7 ELR25520.1 - 2.1e-12 47.1 10.5 0.055 13.9 0.2 7.1 5 2 2 7 7 7 6 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 ELR25520.1 - 0.0041 17.5 12.3 56 4.9 0.1 8.4 10 1 0 10 10 10 0 Leucine Rich Repeat SAM_Ste50p PF09235.10 ELR25520.1 - 0.011 16.0 4.5 0.14 12.4 0.0 4.1 5 0 0 5 5 5 0 Ste50p, sterile alpha motif AAA PF00004.29 ELR25521.1 - 1.1e-16 61.4 0.0 2.7e-16 60.2 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 ELR25521.1 - 1.1e-12 48.7 0.4 2.6e-10 40.9 0.0 3.2 2 1 0 2 2 2 1 AAA ATPase domain AAA_lid_10 PF17872.1 ELR25521.1 - 6.2e-09 35.9 0.2 1.4e-08 34.8 0.2 1.5 1 0 0 1 1 1 1 AAA lid domain AAA_22 PF13401.6 ELR25521.1 - 4e-06 27.1 0.0 2.4e-05 24.7 0.0 2.2 1 1 1 2 2 2 1 AAA domain Cdc6_C PF09079.11 ELR25521.1 - 5e-05 23.2 0.0 0.00012 22.0 0.0 1.6 1 0 0 1 1 1 1 CDC6, C terminal winged helix domain DUF2075 PF09848.9 ELR25521.1 - 0.00049 19.4 0.0 0.00073 18.9 0.0 1.3 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) AAA_19 PF13245.6 ELR25521.1 - 0.001 19.4 0.3 0.0067 16.8 0.3 2.3 2 1 0 2 2 2 1 AAA domain AAA_11 PF13086.6 ELR25521.1 - 0.0022 17.8 0.0 0.0046 16.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain TIP49 PF06068.13 ELR25521.1 - 0.0056 15.9 0.0 0.0099 15.1 0.0 1.3 1 0 0 1 1 1 1 TIP49 P-loop domain NACHT PF05729.12 ELR25521.1 - 0.0075 16.2 1.7 0.041 13.8 0.6 2.5 2 1 0 2 2 2 1 NACHT domain AAA_30 PF13604.6 ELR25521.1 - 0.012 15.4 0.1 0.026 14.3 0.1 1.7 1 1 0 1 1 1 0 AAA domain AAA_7 PF12775.7 ELR25521.1 - 0.014 15.0 0.0 0.06 12.8 0.0 1.9 2 0 0 2 2 2 0 P-loop containing dynein motor region T2SSE PF00437.20 ELR25521.1 - 0.034 13.2 0.3 0.09 11.8 0.1 1.7 2 0 0 2 2 2 0 Type II/IV secretion system protein ResIII PF04851.15 ELR25521.1 - 0.044 13.8 0.1 0.44 10.5 0.0 2.4 2 1 0 2 2 2 0 Type III restriction enzyme, res subunit AAA_33 PF13671.6 ELR25521.1 - 0.07 13.3 0.1 0.25 11.5 0.1 1.9 1 1 0 1 1 1 0 AAA domain Sigma54_activat PF00158.26 ELR25521.1 - 0.11 12.2 0.0 0.35 10.5 0.0 1.8 1 1 0 1 1 1 0 Sigma-54 interaction domain NTPase_1 PF03266.15 ELR25521.1 - 0.2 11.6 0.1 0.87 9.5 0.0 2.0 2 0 0 2 2 2 0 NTPase ABC_tran PF00005.27 ELR25522.1 - 7.3e-35 120.5 0.0 1.8e-34 119.2 0.0 1.7 2 0 0 2 2 1 1 ABC transporter ABC_membrane PF00664.23 ELR25522.1 - 2.1e-22 80.1 12.9 2.4e-21 76.6 12.9 2.0 1 1 0 1 1 1 1 ABC transporter transmembrane region SMC_N PF02463.19 ELR25522.1 - 4.6e-06 26.2 0.0 6.2e-05 22.5 0.0 2.0 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain MMR_HSR1 PF01926.23 ELR25522.1 - 0.0081 16.2 0.0 0.023 14.8 0.0 1.9 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_29 PF13555.6 ELR25522.1 - 0.023 14.4 2.1 0.033 13.9 0.2 2.2 2 1 0 2 2 2 0 P-loop containing region of AAA domain DUF815 PF05673.13 ELR25522.1 - 0.032 13.4 0.0 0.057 12.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) G-alpha PF00503.20 ELR25522.1 - 0.048 12.8 0.0 0.078 12.1 0.0 1.3 1 0 0 1 1 1 0 G-protein alpha subunit Gtr1_RagA PF04670.12 ELR25522.1 - 0.052 12.9 0.0 0.19 11.0 0.0 1.9 2 0 0 2 2 2 0 Gtr1/RagA G protein conserved region AAA_16 PF13191.6 ELR25522.1 - 0.063 13.7 0.1 0.16 12.4 0.1 1.7 1 1 0 1 1 1 0 AAA ATPase domain DUF87 PF01935.17 ELR25522.1 - 0.087 12.9 0.0 0.23 11.5 0.0 1.6 2 0 0 2 2 2 0 Helicase HerA, central domain AAA_15 PF13175.6 ELR25522.1 - 0.095 12.4 0.0 0.44 10.2 0.0 1.8 2 0 0 2 2 2 0 AAA ATPase domain AAA_22 PF13401.6 ELR25522.1 - 0.16 12.3 0.0 0.4 11.0 0.0 1.8 1 1 0 1 1 1 0 AAA domain AAA_21 PF13304.6 ELR25522.1 - 0.2 11.5 0.1 0.83 9.4 0.0 1.9 1 1 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 ELR25522.1 - 0.21 12.1 0.1 0.56 10.7 0.1 1.6 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.6 ELR25522.1 - 0.45 10.7 1.7 1.7 8.9 0.5 2.6 2 1 0 2 2 2 0 AAA domain MORN_2 PF07661.13 ELR25523.1 - 3.5e-19 66.6 13.0 2.8e-05 23.9 0.0 5.8 4 1 2 6 6 6 5 MORN repeat variant MORN PF02493.20 ELR25523.1 - 0.0002 21.1 14.7 0.11 12.5 0.2 4.7 4 1 0 4 4 4 2 MORN repeat RRM_1 PF00076.22 ELR25524.1 - 0.014 15.2 0.0 0.031 14.1 0.0 1.6 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-DBF PF07535.12 ELR25525.1 - 0.0057 16.7 1.3 0.0057 16.7 1.3 2.4 2 0 0 2 2 2 1 DBF zinc finger zf-C2H2_jaz PF12171.8 ELR25525.1 - 0.013 15.8 2.3 0.013 15.8 2.3 2.3 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-CCHC_3 PF13917.6 ELR25525.1 - 0.4 10.7 3.1 0.29 11.1 0.4 2.2 2 0 0 2 2 2 0 Zinc knuckle zf-CCHC_6 PF15288.6 ELR25525.1 - 1.4 8.8 8.1 0.55 10.1 3.7 2.8 2 1 0 2 2 2 0 Zinc knuckle CLIP1_ZNF PF16641.5 ELR25525.1 - 1.7 8.6 8.8 0.32 10.9 1.2 2.5 2 0 0 2 2 2 0 CLIP1 zinc knuckle SKICH PF17751.1 ELR25526.1 - 5.7e-20 71.8 0.0 0.00011 22.7 0.0 3.6 3 0 0 3 3 3 3 SKICH domain HECW_N PF16562.5 ELR25526.1 - 4.4e-11 42.6 0.1 0.012 15.4 0.0 3.3 3 0 0 3 3 3 3 N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2 CUE PF02845.16 ELR25526.1 - 0.0082 15.8 1.3 0.036 13.8 1.3 2.0 1 1 0 1 1 1 1 CUE domain SpoIIIAH PF12685.7 ELR25526.1 - 4.2 7.1 6.6 0.21 11.4 1.1 1.5 2 0 0 2 2 2 0 SpoIIIAH-like protein Ras PF00071.22 ELR25527.1 - 2.2e-38 131.4 0.0 2.6e-38 131.2 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR25527.1 - 1e-26 93.5 0.0 1.5e-26 92.9 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR25527.1 - 1.6e-10 40.7 0.1 2.5e-10 40.1 0.1 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 ELR25527.1 - 2.6e-05 23.7 0.0 4e-05 23.1 0.0 1.5 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region G-alpha PF00503.20 ELR25527.1 - 6.8e-05 22.2 0.1 0.12 11.5 0.0 2.1 2 0 0 2 2 2 2 G-protein alpha subunit AAA_7 PF12775.7 ELR25527.1 - 0.0012 18.4 0.0 0.0019 17.7 0.0 1.2 1 0 0 1 1 1 1 P-loop containing dynein motor region MMR_HSR1 PF01926.23 ELR25527.1 - 0.0015 18.6 0.0 0.0029 17.7 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase TniB PF05621.11 ELR25527.1 - 0.0071 15.8 0.0 0.011 15.2 0.0 1.2 1 0 0 1 1 1 1 Bacterial TniB protein PduV-EutP PF10662.9 ELR25527.1 - 0.011 15.5 0.0 0.073 12.8 0.0 1.9 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation cobW PF02492.19 ELR25527.1 - 0.012 15.2 0.0 0.73 9.4 0.0 2.3 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain SRPRB PF09439.10 ELR25527.1 - 0.018 14.5 0.0 0.029 13.8 0.0 1.3 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit GTP_EFTU PF00009.27 ELR25527.1 - 0.019 14.5 0.1 0.17 11.4 0.0 2.1 1 1 1 2 2 2 0 Elongation factor Tu GTP binding domain AAA PF00004.29 ELR25527.1 - 0.067 13.6 0.0 0.094 13.1 0.0 1.5 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) TsaE PF02367.17 ELR25527.1 - 0.078 13.0 0.0 0.15 12.0 0.0 1.5 1 1 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE RsgA_GTPase PF03193.16 ELR25527.1 - 0.085 12.8 0.0 13 5.6 0.0 2.2 2 0 0 2 2 2 0 RsgA GTPase AAA_24 PF13479.6 ELR25527.1 - 0.099 12.3 0.0 0.16 11.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 ELR25527.1 - 0.16 12.3 0.0 0.27 11.6 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain AAA_22 PF13401.6 ELR25527.1 - 0.17 12.2 0.0 0.34 11.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain PADR1 PF08063.12 ELR25528.1 - 3.9e-09 36.1 7.2 5.8e-09 35.6 7.2 1.3 1 0 0 1 1 1 1 PADR1 (NUC008) domain SAP PF02037.27 ELR25528.1 - 6.4e-05 22.6 0.2 0.00015 21.4 0.2 1.6 1 0 0 1 1 1 1 SAP domain Myc_N PF01056.18 ELR25528.1 - 5 6.9 32.9 4.2 7.2 17.9 2.2 2 0 0 2 2 2 0 Myc amino-terminal region Merozoite_SPAM PF07133.11 ELR25528.1 - 7.2 6.6 45.2 0.76 9.7 26.3 2.2 2 0 0 2 2 2 0 Merozoite surface protein (SPAM) EF-hand_1 PF00036.32 ELR25529.1 - 6.1e-26 88.0 11.3 3.5e-06 26.2 0.2 4.7 5 0 0 5 5 5 4 EF hand EF-hand_7 PF13499.6 ELR25529.1 - 3.4e-24 85.1 2.2 4.3e-12 46.3 0.6 2.5 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 ELR25529.1 - 3.3e-20 70.2 7.6 0.00023 20.8 0.0 5.2 5 0 0 5 5 5 4 EF-hand domain EF-hand_5 PF13202.6 ELR25529.1 - 2.9e-16 58.1 10.2 2.7e-05 23.5 0.1 4.7 4 0 0 4 4 4 3 EF hand DeoC PF01791.9 ELR25529.1 - 2.9e-12 46.7 5.0 4.3e-12 46.2 5.0 1.2 1 0 0 1 1 1 1 DeoC/LacD family aldolase EF-hand_8 PF13833.6 ELR25529.1 - 2.6e-09 36.8 9.6 0.00041 20.1 0.9 4.9 5 1 1 6 6 6 3 EF-hand domain pair SPARC_Ca_bdg PF10591.9 ELR25529.1 - 3.6e-07 30.5 0.0 0.014 15.7 0.0 2.5 2 0 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 ELR25529.1 - 0.00054 19.9 2.7 0.2 11.6 0.5 3.1 1 1 2 3 3 3 2 Cytoskeletal-regulatory complex EF hand DHO_dh PF01180.21 ELR25529.1 - 0.00088 18.6 0.1 0.0015 17.8 0.1 1.3 1 0 0 1 1 1 1 Dihydroorotate dehydrogenase Glu_synthase PF01645.17 ELR25529.1 - 0.0031 16.7 0.5 0.0051 16.0 0.5 1.3 1 0 0 1 1 1 1 Conserved region in glutamate synthase FMN_dh PF01070.18 ELR25529.1 - 0.073 12.1 4.3 0.15 11.1 4.3 1.6 1 1 0 1 1 1 0 FMN-dependent dehydrogenase EF-hand_9 PF14658.6 ELR25529.1 - 0.14 12.5 0.1 3.7 7.9 0.1 2.9 3 0 0 3 3 3 0 EF-hand domain RhoGEF PF00621.20 ELR25530.1 - 3.4e-38 131.7 0.0 4.6e-38 131.3 0.0 1.2 1 0 0 1 1 1 1 RhoGEF domain PH_6 PF15406.6 ELR25530.1 - 0.057 13.7 0.9 0.098 12.9 0.0 1.9 2 0 0 2 2 2 0 Pleckstrin homology domain BAR_3 PF16746.5 ELR25531.1 - 1.4e-12 47.8 13.7 2.1e-12 47.2 13.7 1.2 1 0 0 1 1 1 1 BAR domain of APPL family RasGAP PF00616.19 ELR25531.1 - 7.8e-05 22.5 0.0 7.8e-05 22.5 0.0 2.4 2 1 0 2 2 2 1 GTPase-activator protein for Ras-like GTPase Mannitol_dh PF01232.23 ELR25531.1 - 0.055 13.6 0.2 0.22 11.7 0.1 2.0 1 1 0 1 1 1 0 Mannitol dehydrogenase Rossmann domain RasGAP PF00616.19 ELR25532.1 - 2.8e-16 59.9 0.3 6.5e-16 58.7 0.0 1.7 2 1 0 2 2 2 1 GTPase-activator protein for Ras-like GTPase Pneumo_M2 PF07380.11 ELR25532.1 - 0.046 14.0 0.6 0.7 10.2 0.4 2.7 2 2 0 2 2 2 0 Pneumovirus M2 protein Peptidase_C1 PF00112.23 ELR25533.1 - 4e-60 203.6 2.8 5e-60 203.3 2.8 1.1 1 0 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.12 ELR25533.1 - 9.1e-15 54.9 0.0 1.4e-14 54.3 0.0 1.3 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Peptidase_C1_2 PF03051.15 ELR25533.1 - 0.00037 19.4 2.0 0.0006 18.7 0.3 2.0 2 1 1 3 3 3 1 Peptidase C1-like family DUF755 PF05501.11 ELR25534.1 - 0.00024 21.4 4.9 0.00038 20.7 4.9 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF755) SAGA-Tad1 PF12767.7 ELR25534.1 - 0.0049 16.6 0.2 0.0057 16.4 0.2 1.1 1 0 0 1 1 1 1 Transcriptional regulator of RNA polII, SAGA, subunit SRP-alpha_N PF04086.13 ELR25534.1 - 0.17 11.7 6.7 0.23 11.4 6.7 1.1 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal RR_TM4-6 PF06459.12 ELR25534.1 - 0.18 11.6 2.4 0.24 11.2 2.4 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Nucleo_P87 PF07267.11 ELR25534.1 - 0.2 10.5 0.5 0.22 10.3 0.5 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 FAM60A PF15396.6 ELR25534.1 - 0.3 11.1 5.4 0.39 10.7 5.4 1.1 1 0 0 1 1 1 0 Protein Family FAM60A Presenilin PF01080.17 ELR25534.1 - 0.77 8.5 2.7 0.87 8.3 2.7 1.0 1 0 0 1 1 1 0 Presenilin MRI PF15325.6 ELR25534.1 - 1.8 9.7 6.5 2 9.5 5.2 1.7 1 1 1 2 2 2 0 Modulator of retrovirus infection Rrn6 PF10214.9 ELR25534.1 - 2.3 6.6 7.5 2.7 6.4 7.5 1.0 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor CDC45 PF02724.14 ELR25534.1 - 8 4.6 8.7 9.8 4.3 8.7 1.1 1 0 0 1 1 1 0 CDC45-like protein Metallophos PF00149.28 ELR25535.1 - 2.1e-37 129.6 0.3 2.8e-37 129.2 0.3 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 ELR25535.1 - 0.00034 21.0 0.9 0.00093 19.6 0.9 1.7 1 0 0 1 1 1 1 Serine-threonine protein phosphatase N-terminal domain Metallophos_2 PF12850.7 ELR25535.1 - 0.024 14.8 0.0 0.039 14.1 0.0 1.4 1 0 0 1 1 1 0 Calcineurin-like phosphoesterase superfamily domain Cofilin_ADF PF00241.20 ELR25536.1 - 1.8e-41 140.8 0.1 2e-41 140.6 0.1 1.0 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein Tox-HNH-EHHH PF15657.6 ELR25536.1 - 0.022 15.1 0.1 0.045 14.1 0.1 1.5 1 0 0 1 1 1 0 HNH/Endo VII superfamily nuclease toxins C2 PF00168.30 ELR25537.1 - 1.4e-12 47.8 0.0 2.6e-12 46.9 0.0 1.3 1 0 0 1 1 1 1 C2 domain V-SNARE_C PF12352.8 ELR25537.1 - 9.3e-05 22.6 11.9 0.00014 22.1 1.8 3.1 3 1 0 3 3 3 2 Snare region anchored in the vesicle membrane C-terminus Laminin_II PF06009.12 ELR25537.1 - 0.045 13.8 3.1 0.5 10.4 0.1 2.2 2 0 0 2 2 2 0 Laminin Domain II MCPsignal PF00015.21 ELR25537.1 - 0.055 13.3 0.3 0.42 10.4 0.1 2.1 2 0 0 2 2 2 0 Methyl-accepting chemotaxis protein (MCP) signalling domain V-SNARE PF05008.15 ELR25537.1 - 0.063 13.7 3.6 0.42 11.0 0.3 2.6 2 0 0 2 2 2 0 Vesicle transport v-SNARE protein N-terminus PI3K_C2 PF00792.24 ELR25537.1 - 0.17 11.8 0.0 0.35 10.8 0.0 1.5 1 0 0 1 1 1 0 Phosphoinositide 3-kinase C2 DUF5089 PF17002.5 ELR25537.1 - 0.22 11.3 11.6 5.4 6.8 11.6 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF5089) ThiF PF00899.21 ELR25538.1 - 2.7e-33 115.3 0.0 3.5e-33 115.0 0.0 1.1 1 0 0 1 1 1 1 ThiF family Shikimate_DH PF01488.20 ELR25538.1 - 0.0097 16.0 0.0 0.031 14.4 0.0 1.9 1 1 1 2 2 2 1 Shikimate / quinate 5-dehydrogenase Transthyretin PF00576.21 ELR25539.1 - 5.1e-34 117.3 0.0 5.8e-34 117.1 0.0 1.0 1 0 0 1 1 1 1 HIUase/Transthyretin family CarboxypepD_reg PF13620.6 ELR25539.1 - 9.2e-05 22.6 0.3 0.0002 21.6 0.1 1.7 1 1 1 2 2 2 1 Carboxypeptidase regulatory-like domain Big_1 PF02369.16 ELR25539.1 - 0.015 15.3 0.2 0.022 14.8 0.2 1.3 1 0 0 1 1 1 0 Bacterial Ig-like domain (group 1) SdrD_B PF17210.3 ELR25539.1 - 0.051 13.8 0.0 0.077 13.2 0.0 1.3 1 0 0 1 1 1 0 SdrD B-like domain VID27 PF08553.10 ELR25541.1 - 2.9e-122 408.2 0.0 4.4e-122 407.5 0.0 1.2 1 0 0 1 1 1 1 VID27 C-terminal WD40-like domain VID27_PH PF17747.1 ELR25541.1 - 1.5e-09 38.1 2.0 2e-07 31.2 0.1 3.1 3 0 0 3 3 3 1 VID27 PH-like domain VID27_N PF17748.1 ELR25541.1 - 0.00037 20.4 0.0 0.00037 20.4 0.0 2.9 3 0 0 3 3 2 1 VID27 N-terminal region DUF3273 PF11677.8 ELR25541.1 - 0.034 13.5 0.0 0.052 12.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3273) DUF913 PF06025.12 ELR25541.1 - 0.26 10.2 3.8 11 4.9 0.0 2.2 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) SDA1 PF05285.12 ELR25541.1 - 0.68 9.3 12.3 1 8.7 12.3 1.2 1 0 0 1 1 1 0 SDA1 Nop14 PF04147.12 ELR25541.1 - 0.7 8.0 15.0 0.99 7.5 15.0 1.1 1 0 0 1 1 1 0 Nop14-like family DNA_pol_phi PF04931.13 ELR25541.1 - 1.3 7.0 14.7 1.8 6.6 14.7 1.1 1 0 0 1 1 1 0 DNA polymerase phi FAM176 PF14851.6 ELR25541.1 - 2.1 8.0 6.5 4.8 6.8 6.5 1.5 1 0 0 1 1 1 0 FAM176 family CDC45 PF02724.14 ELR25541.1 - 2.8 6.1 13.1 4.3 5.5 13.1 1.2 1 0 0 1 1 1 0 CDC45-like protein CobT PF06213.12 ELR25541.1 - 5.6 6.3 13.8 8.4 5.7 13.8 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT NOA36 PF06524.12 ELR25541.1 - 6.3 6.0 15.2 10 5.3 15.2 1.3 1 0 0 1 1 1 0 NOA36 protein SPX PF03105.19 ELR25542.1 - 1.3 8.8 7.3 1.6 8.6 7.3 1.0 1 0 0 1 1 1 0 SPX domain zf-Mss51 PF13824.6 ELR25542.1 - 2.1 8.5 5.7 76 3.5 0.8 2.6 1 1 1 2 2 2 0 Zinc-finger of mitochondrial splicing suppressor 51 zf-CCHC PF00098.23 ELR25543.1 - 0.11 12.6 0.5 0.23 11.6 0.5 1.5 1 0 0 1 1 1 0 Zinc knuckle LRR_8 PF13855.6 ELR25545.1 - 1.8e-15 56.4 3.5 5.8e-11 42.0 0.5 3.7 3 1 1 4 4 4 2 Leucine rich repeat zf-C3HC4_3 PF13920.6 ELR25545.1 - 6.6e-12 45.1 13.9 1.5e-11 44.0 13.9 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) LRR_4 PF12799.7 ELR25545.1 - 3.8e-10 39.9 7.4 0.00036 20.9 0.2 3.9 4 0 0 4 4 4 2 Leucine Rich repeats (2 copies) Prok-RING_4 PF14447.6 ELR25545.1 - 1.9e-05 24.4 10.4 3.9e-05 23.4 10.4 1.6 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 LRR_1 PF00560.33 ELR25545.1 - 0.0034 17.7 11.2 2.3 9.1 0.2 5.2 6 0 0 6 6 6 2 Leucine Rich Repeat zf-RING_5 PF14634.6 ELR25545.1 - 0.022 14.7 13.5 0.022 14.7 13.5 1.9 2 0 0 2 2 2 0 zinc-RING finger domain GOLGA2L5 PF15070.6 ELR25545.1 - 0.031 12.9 7.1 0.041 12.6 7.1 1.1 1 0 0 1 1 1 0 Putative golgin subfamily A member 2-like protein 5 PBP_sp32 PF07222.12 ELR25545.1 - 1.1 8.7 5.7 1.7 8.0 5.7 1.3 1 0 0 1 1 1 0 Proacrosin binding protein sp32 Metallophos PF00149.28 ELR25546.1 - 2.1e-08 34.9 0.1 5.7e-08 33.5 0.1 1.6 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 ELR25546.1 - 6.3e-07 29.7 0.0 8.8e-07 29.3 0.0 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Acetyltransf_1 PF00583.25 ELR25547.1 - 1.3e-10 41.6 0.0 1.7e-10 41.1 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 ELR25547.1 - 9.5e-10 38.5 0.1 1.4e-09 38.0 0.1 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 ELR25547.1 - 5.7e-08 33.1 0.1 8.7e-08 32.5 0.1 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.7 ELR25547.1 - 0.00027 21.6 0.0 0.00035 21.2 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 ELR25547.1 - 0.00079 19.5 0.0 0.0014 18.7 0.0 1.4 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase Acetyltransf_4 PF13420.7 ELR25547.1 - 0.0033 17.6 0.0 0.0045 17.1 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 ELR25547.1 - 0.0044 17.0 0.0 0.014 15.4 0.0 1.7 2 0 0 2 2 2 1 FR47-like protein Acetyltransf_13 PF13880.6 ELR25547.1 - 0.033 14.2 0.1 0.059 13.4 0.1 1.4 1 0 0 1 1 1 0 ESCO1/2 acetyl-transferase TPT PF03151.16 ELR25548.1 - 1.3e-11 44.4 17.5 1.4e-06 27.9 4.0 2.1 1 1 1 2 2 2 2 Triose-phosphate Transporter family Aminotran_1_2 PF00155.21 ELR25549.1 - 6.1e-46 157.3 0.0 7.6e-46 156.9 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.21 ELR25549.1 - 0.033 13.5 0.0 0.054 12.8 0.0 1.3 1 0 0 1 1 1 0 Beta-eliminating lyase TMP-TENI PF02581.17 ELR25549.1 - 0.034 13.5 0.0 0.12 11.7 0.0 1.8 2 0 0 2 2 2 0 Thiamine monophosphate synthase Aminotran_5 PF00266.19 ELR25549.1 - 0.036 13.0 0.0 0.055 12.4 0.0 1.2 1 0 0 1 1 1 0 Aminotransferase class-V Aminotran_3 PF00202.21 ELR25549.1 - 0.047 12.4 0.0 0.21 10.2 0.0 1.8 1 1 0 1 1 1 0 Aminotransferase class-III Aminotran_MocR PF12897.7 ELR25549.1 - 0.056 12.2 0.0 0.097 11.4 0.0 1.5 1 1 0 1 1 1 0 Alanine-glyoxylate amino-transferase Hexapep PF00132.24 ELR25550.1 - 6.5e-12 44.7 3.6 3.1e-05 23.5 0.0 4.3 3 1 1 4 4 4 3 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 ELR25550.1 - 0.0056 16.4 4.9 0.39 10.5 0.4 3.9 2 1 1 3 3 3 2 Hexapeptide repeat of succinyl-transferase Fucokinase PF07959.12 ELR25550.1 - 0.18 10.7 0.1 8.8 5.1 0.1 2.1 1 1 0 2 2 2 0 L-fucokinase ATP-grasp_2 PF08442.10 ELR25551.1 - 1e-70 237.5 0.1 1.8e-70 236.6 0.1 1.4 1 0 0 1 1 1 1 ATP-grasp domain Ligase_CoA PF00549.19 ELR25551.1 - 3.3e-25 88.7 0.9 5.6e-25 87.9 0.9 1.4 1 0 0 1 1 1 1 CoA-ligase ATP-grasp_5 PF13549.6 ELR25551.1 - 9e-09 35.1 0.6 3.4e-08 33.2 0.1 2.1 2 1 0 2 2 2 1 ATP-grasp domain GARS_A PF01071.19 ELR25551.1 - 0.0006 19.6 0.8 0.02 14.7 0.0 2.5 2 0 0 2 2 2 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain Toprim_2 PF13155.6 ELR25551.1 - 0.012 16.1 0.0 0.038 14.4 0.0 1.9 1 0 0 1 1 1 0 Toprim-like Peripla_BP_3 PF13377.6 ELR25551.1 - 0.032 14.6 0.1 3.2 8.0 0.0 2.5 2 0 0 2 2 2 0 Periplasmic binding protein-like domain DUF937 PF06078.11 ELR25551.1 - 0.04 14.5 0.4 0.45 11.1 0.6 2.3 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF937) Ribosomal_L12 PF00542.19 ELR25551.1 - 1.5 9.2 4.9 0.87 10.0 0.5 2.7 3 0 0 3 3 3 0 Ribosomal protein L7/L12 C-terminal domain DnaJ PF00226.31 ELR25552.1 - 2.2e-26 91.7 2.9 2.2e-26 91.7 2.9 2.2 2 0 0 2 2 2 1 DnaJ domain DnaJ-X PF14308.6 ELR25552.1 - 4.4e-21 75.3 0.1 4.4e-21 75.3 0.1 2.9 2 2 1 3 3 3 1 X-domain of DnaJ-containing MCPVI PF02993.14 ELR25552.1 - 0.0024 17.8 1.0 0.0024 17.8 1.0 2.6 2 1 0 2 2 2 1 Minor capsid protein VI BAG6 PF12057.8 ELR25552.1 - 0.25 11.1 2.9 7.7 6.2 0.0 3.9 4 0 0 4 4 4 0 BCL2-associated athanogene 6 RR_TM4-6 PF06459.12 ELR25552.1 - 6 6.6 19.1 0.25 11.1 2.0 3.1 3 0 0 3 3 3 0 Ryanodine Receptor TM 4-6 Pkinase_Tyr PF07714.17 ELR25553.1 - 7.6e-129 428.5 0.0 3.4e-63 213.4 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 ELR25553.1 - 5.1e-110 367.0 0.0 1.6e-54 185.1 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain PBP_like_2 PF12849.7 ELR25553.1 - 2.5e-32 112.7 11.5 3e-22 79.6 0.7 2.3 2 0 0 2 2 2 2 PBP superfamily domain Guanylate_cyc PF00211.20 ELR25553.1 - 2.8e-14 53.1 0.0 5.2e-14 52.3 0.0 1.4 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain APH PF01636.23 ELR25553.1 - 2.6e-07 30.8 0.8 0.00022 21.2 0.0 2.9 3 0 0 3 3 3 2 Phosphotransferase enzyme family Haspin_kinase PF12330.8 ELR25553.1 - 0.00026 20.1 0.0 0.033 13.1 0.0 2.4 2 0 0 2 2 2 1 Haspin like kinase domain Kinase-like PF14531.6 ELR25553.1 - 0.001 18.5 0.0 0.33 10.2 0.0 2.3 2 0 0 2 2 2 2 Kinase-like DUF347 PF03988.12 ELR25553.1 - 0.0054 16.9 1.9 0.013 15.7 0.4 2.4 2 0 0 2 2 2 1 Repeat of Unknown Function (DUF347) RIO1 PF01163.22 ELR25553.1 - 0.01 15.4 1.4 0.61 9.7 0.1 2.3 2 0 0 2 2 2 0 RIO1 family EGF_2 PF07974.13 ELR25553.1 - 0.013 15.9 10.6 0.024 15.0 10.6 1.5 1 0 0 1 1 1 0 EGF-like domain Kdo PF06293.14 ELR25553.1 - 0.034 13.5 0.2 7.4 5.9 0.0 2.5 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family FTA2 PF13095.6 ELR25553.1 - 0.044 13.4 0.1 0.79 9.3 0.0 2.6 3 1 0 3 3 3 0 Kinetochore Sim4 complex subunit FTA2 SKG6 PF08693.10 ELR25553.1 - 0.16 11.4 9.2 0.0091 15.4 2.7 2.3 2 0 0 2 2 2 0 Transmembrane alpha-helix domain HHV-5_US34A PF17087.5 ELR25553.1 - 0.17 12.1 0.0 0.47 10.6 0.0 1.7 1 0 0 1 1 1 0 Herpesvirus US34A protein family EGF_Tenascin PF18720.1 ELR25553.1 - 4.5 7.4 8.2 10 6.3 8.2 1.6 1 0 0 1 1 1 0 Tenascin EGF domain FHA_2 PF17913.1 ELR25554.1 - 6.2e-15 55.2 0.0 1.2e-14 54.3 0.0 1.4 1 0 0 1 1 1 1 FHA domain zf-PARP PF00645.18 ELR25554.1 - 1e-10 42.3 0.1 2.8e-10 40.9 0.1 1.8 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region zf-CCHH PF10283.9 ELR25554.1 - 3.4e-10 39.7 4.2 6.2e-10 38.9 4.2 1.4 1 0 0 1 1 1 1 PBZ domain YL1 PF05764.13 ELR25554.1 - 0.00012 22.3 3.4 0.00012 22.3 3.4 3.7 3 1 1 4 4 4 2 YL1 nuclear protein CUE PF02845.16 ELR25554.1 - 0.0028 17.3 0.0 0.005 16.5 0.0 1.4 1 0 0 1 1 1 1 CUE domain RNA12 PF10443.9 ELR25555.1 - 1.7e-12 46.9 2.0 4.8e-05 22.3 2.0 4.1 2 1 1 3 3 3 3 RNA12 protein ATPase_2 PF01637.18 ELR25555.1 - 3.1e-11 43.6 0.0 3.1e-11 43.6 0.0 2.2 2 1 0 2 2 1 1 ATPase domain predominantly from Archaea Exonuc_VII_L PF02601.15 ELR25555.1 - 0.0065 16.1 3.3 0.023 14.3 3.0 1.9 2 0 0 2 2 2 1 Exonuclease VII, large subunit AAA_16 PF13191.6 ELR25555.1 - 0.016 15.6 0.1 0.15 12.4 0.0 2.6 2 1 0 2 2 2 0 AAA ATPase domain AAA_14 PF13173.6 ELR25555.1 - 0.016 15.2 0.6 0.1 12.6 0.0 2.5 2 0 0 2 2 2 0 AAA domain AAA_22 PF13401.6 ELR25555.1 - 0.019 15.2 0.1 0.24 11.7 0.0 2.7 2 1 0 2 2 2 0 AAA domain AAA_33 PF13671.6 ELR25555.1 - 0.044 13.9 0.0 0.11 12.6 0.0 1.7 1 0 0 1 1 1 0 AAA domain SprA-related PF12118.8 ELR25555.1 - 0.14 11.2 1.2 0.19 10.8 1.2 1.1 1 0 0 1 1 1 0 SprA-related family DUF4559 PF15112.6 ELR25555.1 - 0.16 11.6 9.9 0.36 10.5 8.9 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4559) STAT_alpha PF01017.20 ELR25555.1 - 0.39 10.6 12.4 2.6 7.9 12.4 2.1 1 1 0 1 1 1 0 STAT protein, all-alpha domain Spc7 PF08317.11 ELR25555.1 - 0.62 8.9 19.5 1 8.1 19.5 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein LMBR1 PF04791.16 ELR25555.1 - 1.5 7.6 6.1 2.4 7.0 6.1 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein Sec34 PF04136.15 ELR25555.1 - 1.6 8.6 10.5 18 5.2 0.3 3.5 2 1 1 3 3 3 0 Sec34-like family SH3_1 PF00018.28 ELR25556.1 - 9.7e-11 41.1 0.1 1.6e-10 40.4 0.1 1.4 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 ELR25556.1 - 1.8e-10 40.5 0.1 3.1e-10 39.7 0.1 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 ELR25556.1 - 7.1e-09 35.2 0.1 1.2e-08 34.5 0.1 1.4 1 0 0 1 1 1 1 Variant SH3 domain SHE3 PF17078.5 ELR25557.1 - 0.5 10.0 29.3 0.9 9.2 13.1 3.2 3 1 0 3 3 3 0 SWI5-dependent HO expression protein 3 NOA36 PF06524.12 ELR25557.1 - 6.9 5.9 11.8 21 4.3 11.8 1.8 1 0 0 1 1 1 0 NOA36 protein CitMHS PF03600.16 ELR25558.1 - 1.8e-50 171.8 16.0 1.8e-50 171.8 16.0 2.3 2 1 1 3 3 3 2 Citrate transporter ArsB PF02040.15 ELR25558.1 - 0.034 13.5 30.5 0.0073 15.7 12.3 2.6 2 1 0 2 2 2 0 Arsenical pump membrane protein CBP_BcsF PF11120.8 ELR25558.1 - 0.037 14.1 0.1 0.037 14.1 0.1 2.2 2 0 0 2 2 2 0 Cellulose biosynthesis protein BcsF WD40_3 PF15911.5 ELR25558.1 - 0.27 11.3 1.2 0.58 10.2 0.2 2.0 2 0 0 2 2 2 0 WD domain, G-beta repeat DUF2621 PF11084.8 ELR25558.1 - 0.32 11.0 1.6 0.6 10.1 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2621) Flavi_NS4A PF01350.17 ELR25558.1 - 1.3 8.9 12.1 0.29 11.1 2.0 3.1 3 2 0 3 3 3 0 Flavivirus non-structural protein NS4A DUF4131 PF13567.6 ELR25558.1 - 7.9 6.1 0.0 7.9 6.1 0.0 4.0 5 1 0 5 5 5 0 Domain of unknown function (DUF4131) MFS_1 PF07690.16 ELR25560.1 - 5.8e-41 140.6 64.1 4e-34 118.1 39.7 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily DPM2 PF07297.12 ELR25560.1 - 0.27 11.6 0.1 0.27 11.6 0.1 2.8 2 1 0 2 2 2 0 Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2) DUF624 PF04854.14 ELR25560.1 - 1.6 8.9 7.6 0.6 10.3 0.3 3.1 3 0 0 3 3 3 0 Protein of unknown function, DUF624 Hist_deacetyl PF00850.19 ELR25561.1 - 2.4e-14 53.5 0.1 3.6e-14 53.0 0.1 1.3 1 0 0 1 1 1 1 Histone deacetylase domain Hist_deacetyl PF00850.19 ELR25562.1 - 2.1e-83 280.3 0.0 2.4e-83 280.1 0.0 1.0 1 0 0 1 1 1 1 Histone deacetylase domain DUF5613 PF18467.1 ELR25562.1 - 0.091 13.2 0.7 0.16 12.4 0.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF5613) UCH PF00443.29 ELR25563.1 - 1.2e-47 162.6 0.1 1.6e-47 162.2 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 ELR25563.1 - 3e-13 50.1 0.3 5.4e-13 49.2 0.3 1.4 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase ubiquitin PF00240.23 ELR25563.1 - 3.9e-08 32.9 0.0 2.5e-07 30.3 0.0 2.4 2 1 0 2 2 2 1 Ubiquitin family Peptidase_C98 PF15499.6 ELR25563.1 - 0.0049 16.4 1.7 0.0058 16.1 0.3 1.8 3 0 0 3 3 3 1 Ubiquitin-specific peptidase-like, SUMO isopeptidase FCP1_C PF09309.10 ELR25563.1 - 0.047 13.6 0.2 0.077 12.9 0.2 1.2 1 0 0 1 1 1 0 FCP1, C-terminal SNARE_assoc PF09335.11 ELR25564.1 - 6.2e-29 100.9 5.5 6.2e-29 100.9 5.5 1.9 2 0 0 2 2 2 1 SNARE associated Golgi protein DUF5360 PF17314.2 ELR25564.1 - 0.061 13.4 0.2 0.061 13.4 0.2 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF5360) UQ_con PF00179.26 ELR25565.1 - 1.8e-42 144.3 0.0 2.5e-42 143.8 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 ELR25565.1 - 0.012 15.9 0.1 0.022 15.0 0.1 1.6 1 0 0 1 1 1 0 RWD domain PPP4R2 PF09184.11 ELR25565.1 - 0.17 11.4 14.2 0.21 11.1 14.2 1.2 1 0 0 1 1 1 0 PPP4R2 Nucleo_P87 PF07267.11 ELR25565.1 - 0.32 9.8 6.8 0.37 9.6 6.8 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 NOA36 PF06524.12 ELR25565.1 - 0.51 9.6 17.4 0.65 9.3 17.4 1.1 1 0 0 1 1 1 0 NOA36 protein RNA_pol_3_Rpc31 PF11705.8 ELR25565.1 - 2.6 8.2 22.6 3.4 7.9 22.6 1.1 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 DUF913 PF06025.12 ELR25565.1 - 4.5 6.2 5.1 5.4 5.9 5.1 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) PBP_sp32 PF07222.12 ELR25565.1 - 4.8 6.6 10.3 7.1 6.0 10.3 1.3 1 0 0 1 1 1 0 Proacrosin binding protein sp32 Nop PF01798.18 ELR25566.1 - 8.2e-70 234.9 0.1 1.3e-69 234.2 0.1 1.3 1 0 0 1 1 1 1 snoRNA binding domain, fibrillarin Prp31_C PF09785.9 ELR25566.1 - 1.4e-33 116.4 1.7 1.4e-33 116.4 1.7 1.8 2 0 0 2 2 2 1 Prp31 C terminal domain DUF2452 PF10504.9 ELR25566.1 - 0.012 15.0 0.1 0.029 13.8 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2452) ATP_sub_h PF10775.9 ELR25566.1 - 0.4 10.7 1.9 0.9 9.6 1.9 1.5 1 0 0 1 1 1 0 ATP synthase complex subunit h zf-SCNM1 PF15803.5 ELR25567.1 - 1.6e-12 46.8 0.2 3.6e-12 45.7 0.2 1.6 1 0 0 1 1 1 1 Zinc-finger of sodium channel modifier 1 SCNM1_acidic PF15805.5 ELR25567.1 - 3.1e-11 42.8 2.5 5.2e-11 42.1 2.5 1.3 1 0 0 1 1 1 1 Acidic C-terminal region of sodium channel modifier 1 SCNM1 Dynamin_M PF01031.20 ELR25568.1 - 9.2e-112 372.9 0.2 1.4e-109 365.8 0.0 3.0 3 1 0 3 3 3 1 Dynamin central region Dynamin_N PF00350.23 ELR25568.1 - 1.3e-55 188.0 0.1 3.4e-55 186.7 0.1 1.8 1 0 0 1 1 1 1 Dynamin family GED PF02212.18 ELR25568.1 - 1.9e-30 104.8 1.5 1.9e-30 104.8 1.5 2.6 3 0 0 3 3 3 1 Dynamin GTPase effector domain PCI PF01399.27 ELR25568.1 - 8.6e-21 74.4 0.3 2.8e-19 69.5 0.0 3.3 3 0 0 3 3 3 1 PCI domain RPN5_C PF18098.1 ELR25568.1 - 8.2e-13 48.2 1.9 2.1e-12 46.9 1.9 1.8 1 0 0 1 1 1 1 26S proteasome regulatory subunit RPN5 C-terminal domain MMR_HSR1 PF01926.23 ELR25568.1 - 4.6e-05 23.5 0.1 0.00029 20.9 0.1 2.5 2 1 0 2 2 2 1 50S ribosome-binding GTPase AAA_16 PF13191.6 ELR25568.1 - 0.096 13.1 0.3 0.75 10.2 0.0 2.8 4 0 0 4 4 4 0 AAA ATPase domain TFIIA PF03153.13 ELR25568.1 - 0.58 10.1 11.6 1.2 9.0 11.6 1.5 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit CCCAP PF15964.5 ELR25569.1 - 0.0037 15.6 1.4 0.0051 15.2 1.4 1.1 1 0 0 1 1 1 1 Centrosomal colon cancer autoantigen protein family Pih1_fungal_CS PF18482.1 ELR25569.1 - 0.15 12.6 0.1 0.29 11.7 0.1 1.3 1 0 0 1 1 1 0 Fungal Pih1 CS domain YabA PF06156.13 ELR25569.1 - 0.17 12.5 1.1 0.62 10.7 0.3 2.3 3 0 0 3 3 3 0 Initiation control protein YabA TolA_bind_tri PF16331.5 ELR25569.1 - 0.35 11.0 0.0 0.35 11.0 0.0 2.6 2 1 0 2 2 2 0 TolA binding protein trimerisation Tropomyosin_1 PF12718.7 ELR25569.1 - 0.7 10.0 10.8 30 4.7 10.8 2.3 1 1 0 1 1 1 0 Tropomyosin like CENP-F_leu_zip PF10473.9 ELR25569.1 - 1.6 8.7 8.2 4.3 7.4 8.2 1.7 1 1 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF16 PF01519.16 ELR25569.1 - 7.7 7.1 6.5 8 7.0 3.1 2.3 1 1 1 2 2 2 0 Protein of unknown function DUF16 Peptidase_M16 PF00675.20 ELR25570.1 - 1.5e-52 177.5 0.4 3.2e-52 176.5 0.4 1.6 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.21 ELR25570.1 - 3.7e-32 111.8 0.0 1.1e-31 110.3 0.0 1.8 2 0 0 2 2 2 1 Peptidase M16 inactive domain M16C_assoc PF08367.11 ELR25570.1 - 0.085 12.0 0.1 0.17 11.0 0.1 1.4 1 0 0 1 1 1 0 Peptidase M16C associated CAP_N PF01213.19 ELR25571.1 - 1.6e-83 280.8 0.2 2.4e-83 280.3 0.2 1.2 1 0 0 1 1 1 1 Adenylate cyclase associated (CAP) N terminal CAP_C PF08603.11 ELR25571.1 - 7.6e-63 210.8 4.2 1.1e-62 210.4 4.2 1.2 1 0 0 1 1 1 1 Adenylate cyclase associated (CAP) C terminal TBCC PF07986.12 ELR25571.1 - 0.0002 21.1 3.7 0.001 18.8 3.3 2.0 1 1 1 2 2 2 2 Tubulin binding cofactor C WD40 PF00400.32 ELR25572.1 - 1.8e-07 31.7 16.0 0.52 11.3 0.0 8.6 9 0 0 9 9 9 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ELR25572.1 - 3e-05 24.2 0.0 0.91 9.9 0.0 6.0 4 2 3 7 7 7 1 Anaphase-promoting complex subunit 4 WD40 domain F-box-like PF12937.7 ELR25573.1 - 1.1e-11 44.5 0.0 1.1e-11 44.5 0.0 2.0 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 ELR25573.1 - 2.3e-06 27.3 0.0 4.8e-06 26.3 0.0 1.6 1 0 0 1 1 1 1 F-box domain CPBP PF02517.16 ELR25573.1 - 0.00066 20.0 18.9 0.00066 20.0 18.9 2.6 1 1 1 2 2 2 1 CPBP intramembrane metalloprotease F-box_5 PF18511.1 ELR25573.1 - 0.057 13.0 0.0 0.16 11.5 0.0 1.7 1 0 0 1 1 1 0 F-box G-patch PF01585.23 ELR25574.1 - 1.2e-10 41.1 0.8 1.2e-10 41.1 0.8 2.4 2 0 0 2 2 2 1 G-patch domain zf-U11-48K PF05253.12 ELR25574.1 - 5.5e-08 32.6 2.0 1.1e-07 31.6 2.0 1.5 1 0 0 1 1 1 1 U11-48K-like CHHC zinc finger Kelch_4 PF13418.6 ELR25575.1 - 3e-16 59.1 10.4 0.00022 21.2 0.1 6.0 5 1 1 6 6 6 4 Galactose oxidase, central domain Kelch_3 PF13415.6 ELR25575.1 - 1.4e-12 47.5 11.8 0.0002 21.5 0.1 5.4 5 1 0 5 5 5 3 Galactose oxidase, central domain Kelch_5 PF13854.6 ELR25575.1 - 2.7e-11 43.2 12.2 0.0022 17.9 0.1 6.2 5 1 1 6 6 6 3 Kelch motif Kelch_6 PF13964.6 ELR25575.1 - 7.1e-09 35.6 6.4 0.1 12.9 0.1 6.0 5 1 1 6 6 6 3 Kelch motif Kelch_1 PF01344.25 ELR25575.1 - 6.5e-08 32.0 5.8 0.55 9.9 0.1 5.4 5 1 0 5 5 5 3 Kelch motif Kelch_2 PF07646.15 ELR25575.1 - 2.7e-05 23.9 11.2 0.22 11.5 0.0 5.8 5 1 0 5 5 5 2 Kelch motif Rtt106 PF08512.12 ELR25576.1 - 7.3e-13 48.7 0.0 1.1e-12 48.2 0.0 1.2 1 0 0 1 1 1 1 Histone chaperone Rttp106-like POB3_N PF17292.2 ELR25576.1 - 0.043 14.2 0.1 0.19 12.2 0.1 2.2 1 1 0 1 1 1 0 POB3-like N-terminal PH domain THF_DHG_CYH_C PF02882.19 ELR25580.1 - 4.3e-55 185.4 0.6 5.8e-55 185.0 0.6 1.2 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain THF_DHG_CYH PF00763.23 ELR25580.1 - 2.5e-05 24.5 0.1 0.0001 22.5 0.1 1.9 1 1 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain SurE PF01975.17 ELR25581.1 - 2e-40 138.6 0.0 3.3e-40 137.9 0.0 1.4 1 1 0 1 1 1 1 Survival protein SurE DZR PF12773.7 ELR25582.1 - 5.4e-06 26.3 15.7 0.00063 19.7 15.7 2.4 1 1 0 1 1 1 1 Double zinc ribbon zinc_ribbon_2 PF13240.6 ELR25582.1 - 0.0027 17.4 18.6 0.0029 17.3 7.2 3.0 3 0 0 3 3 3 2 zinc-ribbon domain zf_C2H2_13 PF18508.1 ELR25582.1 - 0.038 13.6 0.8 0.038 13.6 0.8 3.2 3 1 1 4 4 4 0 Zinc finger domain zf-ribbon_3 PF13248.6 ELR25582.1 - 0.25 10.8 16.9 0.37 10.3 0.3 3.4 3 1 0 3 3 3 0 zinc-ribbon domain Nudix_N_2 PF14803.6 ELR25582.1 - 0.26 11.3 13.2 0.82 9.6 0.6 3.7 3 1 0 3 3 3 0 Nudix N-terminal NinF PF05810.12 ELR25582.1 - 0.53 10.2 9.9 5.2 7.0 0.3 3.3 1 1 2 3 3 3 0 NinF protein PolC_DP2 PF03833.13 ELR25582.1 - 0.91 7.3 3.3 0.98 7.2 3.3 1.0 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 HNH_5 PF14279.6 ELR25582.1 - 1.1 9.1 8.6 1 9.3 0.1 3.6 2 2 1 3 3 3 0 HNH endonuclease zf-C4pol PF14260.6 ELR25582.1 - 8.4 6.9 13.3 1.3e+03 -0.0 13.4 2.8 1 1 0 1 1 1 0 C4-type zinc-finger of DNA polymerase delta zf_UBZ PF18439.1 ELR25582.1 - 8.6 6.1 10.9 5.5 6.7 0.1 4.0 3 1 1 4 4 4 0 Ubiquitin-Binding Zinc Finger Ank_2 PF12796.7 ELR25583.1 - 2.7e-07 31.1 0.6 6e-06 26.8 0.2 1.7 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 ELR25583.1 - 4.6e-07 29.7 0.4 0.0074 16.7 0.0 2.7 2 1 0 2 2 2 2 Ankyrin repeat Ank_4 PF13637.6 ELR25583.1 - 7.6e-07 29.6 0.1 1.6e-06 28.5 0.1 1.6 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank PF00023.30 ELR25583.1 - 9.5e-07 29.0 0.4 0.0074 16.7 0.2 2.5 2 0 0 2 2 2 2 Ankyrin repeat Ank_5 PF13857.6 ELR25583.1 - 0.00077 19.7 0.6 0.025 14.9 0.1 2.3 1 1 1 2 2 2 1 Ankyrin repeats (many copies) DPM2 PF07297.12 ELR25584.1 - 1.9e-19 69.7 5.5 2.2e-19 69.5 5.5 1.0 1 0 0 1 1 1 1 Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2) COesterase PF00135.28 ELR25586.1 - 2.7e-26 92.5 0.0 3.8e-26 92.0 0.0 1.2 1 0 0 1 1 1 1 Carboxylesterase family Ank_4 PF13637.6 ELR25588.1 - 2.9e-30 104.2 1.6 4.7e-10 39.8 0.0 5.8 4 2 2 6 6 6 6 Ankyrin repeats (many copies) Ank_2 PF12796.7 ELR25588.1 - 1.7e-28 99.0 0.5 8.3e-08 32.7 0.0 4.4 1 1 4 5 5 5 5 Ankyrin repeats (3 copies) Ank_5 PF13857.6 ELR25588.1 - 9.7e-21 73.6 5.3 2.1e-08 34.2 0.0 6.2 3 1 4 7 7 7 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 ELR25588.1 - 2.2e-18 64.4 1.2 0.0048 17.3 0.0 8.0 8 0 0 8 8 8 5 Ankyrin repeat Ank PF00023.30 ELR25588.1 - 1.3e-17 63.3 4.5 6.4e-05 23.2 0.0 6.9 7 0 0 7 7 7 3 Ankyrin repeat F-box-like PF12937.7 ELR25588.1 - 1.4e-09 37.6 0.1 3.3e-09 36.5 0.1 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ELR25588.1 - 4e-06 26.6 0.1 7.7e-06 25.7 0.1 1.5 1 0 0 1 1 1 1 F-box domain PH PF00169.29 ELR25589.1 - 6.5e-05 23.4 0.0 0.00016 22.2 0.0 1.7 1 0 0 1 1 1 1 PH domain Rhomboid PF01694.22 ELR25591.1 - 0.12 12.3 2.7 0.15 12.1 2.7 1.1 1 0 0 1 1 1 0 Rhomboid family PIRT PF15099.6 ELR25591.1 - 0.27 10.8 1.4 0.4 10.3 1.4 1.2 1 0 0 1 1 1 0 Phosphoinositide-interacting protein family EF-1_beta_acid PF10587.9 ELR25592.1 - 6.4 7.3 10.6 2.7 8.5 2.6 2.6 2 0 0 2 2 2 0 Eukaryotic elongation factor 1 beta central acidic region ABC2_membrane PF01061.24 ELR25593.1 - 4.4e-37 127.5 17.6 6.1e-37 127.1 17.6 1.2 1 0 0 1 1 1 1 ABC-2 type transporter EF_assoc_1 PF08355.12 ELR25593.1 - 0.059 13.0 0.3 0.16 11.5 0.3 1.8 1 0 0 1 1 1 0 EF hand associated F-box-like PF12937.7 ELR25596.1 - 0.0039 17.0 1.3 0.28 11.1 1.3 2.5 1 1 0 1 1 1 1 F-box-like F-box PF00646.33 ELR25596.1 - 0.075 12.9 0.0 0.15 12.0 0.0 1.5 1 0 0 1 1 1 0 F-box domain Redoxin PF08534.10 ELR25598.1 - 3.8e-25 88.3 0.3 2.5e-24 85.7 0.3 1.8 1 1 0 1 1 1 1 Redoxin AhpC-TSA PF00578.21 ELR25598.1 - 0.00049 20.0 0.0 0.25 11.2 0.0 2.1 2 0 0 2 2 2 2 AhpC/TSA family GATA PF00320.27 ELR25600.1 - 5.5e-15 54.7 6.5 1.1e-14 53.7 6.5 1.6 1 0 0 1 1 1 1 GATA zinc finger zf-NADH-PPase PF09297.11 ELR25600.1 - 0.56 9.9 3.4 22 4.8 0.2 2.8 2 0 0 2 2 2 0 NADH pyrophosphatase zinc ribbon domain Suf PF05843.14 ELR25600.1 - 2.5 8.0 4.2 5 7.0 4.2 1.5 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) SR-25 PF10500.9 ELR25600.1 - 5.4 6.6 14.6 1 9.0 1.0 3.0 3 0 0 3 3 3 0 Nuclear RNA-splicing-associated protein OrfB_Zn_ribbon PF07282.11 ELR25600.1 - 7.1 6.6 8.7 0.27 11.2 1.0 2.2 2 0 0 2 2 2 0 Putative transposase DNA-binding domain RasGEF PF00617.19 ELR25601.1 - 6.9e-48 163.2 0.2 6.9e-48 163.2 0.2 2.8 3 1 0 3 3 3 1 RasGEF domain LRR_8 PF13855.6 ELR25601.1 - 2.1e-31 107.5 107.9 3.6e-09 36.2 6.4 8.3 3 2 7 10 10 10 10 Leucine rich repeat LRR_4 PF12799.7 ELR25601.1 - 1.4e-22 79.4 54.2 2.8e-08 33.9 3.0 8.9 5 1 5 10 10 10 8 Leucine Rich repeats (2 copies) Drf_GBD PF06371.13 ELR25601.1 - 3.6e-21 75.6 0.0 1e-20 74.1 0.0 1.8 1 0 0 1 1 1 1 Diaphanous GTPase-binding Domain RasGEF_N PF00618.20 ELR25601.1 - 1e-19 70.7 0.4 2.9e-19 69.3 0.4 1.9 1 0 0 1 1 1 1 RasGEF N-terminal motif Drf_FH3 PF06367.16 ELR25601.1 - 4.9e-18 65.5 2.1 1.3e-17 64.0 2.1 1.7 1 0 0 1 1 1 1 Diaphanous FH3 Domain FERM_f0 PF16511.5 ELR25601.1 - 1.7e-15 57.1 0.1 0.0016 18.7 0.0 6.1 6 0 0 6 6 6 3 N-terminal or F0 domain of Talin-head FERM FERM_N PF09379.10 ELR25601.1 - 0.0003 20.7 0.0 0.2 11.6 0.0 4.3 4 1 0 4 4 4 1 FERM N-terminal domain LRR_5 PF13306.6 ELR25601.1 - 0.0044 17.0 5.7 4 7.4 0.0 4.1 3 1 0 4 4 4 2 BspA type Leucine rich repeat region (6 copies) DUF4336 PF14234.6 ELR25602.1 - 2.1e-10 40.3 1.0 1.2e-05 24.7 0.2 3.0 2 1 0 2 2 2 2 Domain of unknown function (DUF4336) PPR_1 PF12854.7 ELR25603.1 - 4.5e-67 221.4 0.0 3.6e-07 29.7 0.0 12.2 12 1 0 12 12 12 9 PPR repeat PPR_2 PF13041.6 ELR25603.1 - 3.1e-66 219.4 0.0 7.1e-12 45.3 0.0 11.5 7 1 5 12 12 12 11 PPR repeat family PPR PF01535.20 ELR25603.1 - 5.5e-53 173.6 0.0 0.00016 21.7 0.0 13.1 13 1 0 13 13 13 10 PPR repeat PPR_3 PF13812.6 ELR25603.1 - 1.4e-48 162.8 0.0 6.8e-08 32.5 0.0 8.8 8 1 1 9 9 9 9 Pentatricopeptide repeat domain PPR_long PF17177.4 ELR25603.1 - 6.2e-31 107.4 0.1 5.4e-06 25.9 0.0 6.0 1 1 5 6 6 6 5 Pentacotripeptide-repeat region of PRORP TPR_19 PF14559.6 ELR25603.1 - 2.3e-07 31.2 7.2 0.09 13.3 0.2 6.0 6 1 1 7 7 6 2 Tetratricopeptide repeat TPR_14 PF13428.6 ELR25603.1 - 8.5e-05 23.1 26.2 0.42 11.6 0.4 10.1 8 4 4 12 12 11 1 Tetratricopeptide repeat TPR_4 PF07721.14 ELR25603.1 - 0.00013 22.3 30.7 1.5 9.7 0.0 9.2 9 0 0 9 9 9 2 Tetratricopeptide repeat TPR_16 PF13432.6 ELR25603.1 - 0.00021 21.9 15.6 1.3 9.7 1.1 6.7 6 2 0 6 6 6 1 Tetratricopeptide repeat Wzy_C_2 PF11846.8 ELR25603.1 - 0.00022 21.2 5.2 4.7 7.1 0.0 5.4 5 3 1 6 6 6 2 Virulence factor membrane-bound polymerase, C-terminal Ribonuc_red_lgN PF00317.21 ELR25603.1 - 0.0068 16.4 0.0 3.2 7.8 0.0 3.7 2 2 0 2 2 2 1 Ribonucleotide reductase, all-alpha domain ATP13 PF12921.7 ELR25603.1 - 0.03 14.2 0.0 15 5.4 0.0 4.5 3 1 3 6 6 6 0 Mitochondrial ATPase expression TPR_12 PF13424.6 ELR25603.1 - 0.059 13.7 7.2 4.8 7.5 0.3 5.8 6 0 0 6 6 6 0 Tetratricopeptide repeat Integrin_beta PF00362.18 ELR25603.1 - 0.11 12.1 0.0 13 5.3 0.0 2.2 2 0 0 2 2 2 0 Integrin beta chain VWA domain DUF3334 PF11813.8 ELR25603.1 - 0.11 12.2 0.0 8.7 6.0 0.1 3.4 3 1 1 4 4 4 0 Protein of unknown function (DUF3334) mRNA_stabil PF13929.6 ELR25603.1 - 0.13 11.2 0.0 19 4.1 0.0 2.5 2 0 0 2 2 2 0 mRNA stabilisation Terminase_4 PF05119.12 ELR25603.1 - 0.15 12.5 0.0 5.7 7.4 0.1 3.0 2 1 1 3 3 2 0 Phage terminase, small subunit Spore_YpjB PF09577.10 ELR25603.1 - 0.16 11.7 0.5 7.7 6.3 0.1 2.4 1 1 1 2 2 2 0 Sporulation protein YpjB (SpoYpjB) Exog_C PF18026.1 ELR25603.1 - 0.22 11.6 0.0 42 4.3 0.0 4.0 5 0 0 5 5 3 0 Endo/exonuclease (EXOG) C-terminal domain CysG_dimeriser PF10414.9 ELR25603.1 - 0.62 9.8 4.5 19 5.0 0.0 5.1 6 0 0 6 6 6 0 Sirohaem synthase dimerisation region YTH PF04146.15 ELR25604.1 - 1.7e-23 83.4 0.0 5.2e-23 81.8 0.0 1.9 1 1 0 1 1 1 1 YT521-B-like domain RlaP PF10127.9 ELR25604.1 - 2.3e-22 79.8 0.5 3.5e-16 59.6 0.0 3.0 3 0 0 3 3 3 2 RNA repair pathway DNA polymerase beta family Optomotor-blind PF11078.8 ELR25604.1 - 0.035 14.7 0.5 0.13 12.8 0.0 2.2 2 0 0 2 2 2 0 Optomotor-blind protein N-terminal region Mucin PF01456.17 ELR25605.1 - 0.00021 21.3 6.0 0.00025 21.1 6.0 1.2 1 0 0 1 1 1 1 Mucin-like glycoprotein RhoGEF PF00621.20 ELR25606.1 - 6e-47 160.2 2.6 6e-47 160.2 2.6 1.9 2 0 0 2 2 2 1 RhoGEF domain C2 PF00168.30 ELR25606.1 - 0.00036 20.8 0.0 0.0014 18.9 0.0 2.1 1 1 0 1 1 1 1 C2 domain PH PF00169.29 ELR25606.1 - 0.0073 16.8 0.2 1.7 9.2 0.0 3.1 2 0 0 2 2 2 1 PH domain RNA_pol_Rpc4 PF05132.14 ELR25607.1 - 2.1e-18 67.2 1.2 2.1e-18 67.2 1.2 3.2 2 2 0 2 2 2 1 RNA polymerase III RPC4 Cytidylate_kin2 PF13189.6 ELR25607.1 - 0.15 12.1 0.4 0.28 11.3 0.3 1.3 1 1 0 1 1 1 0 Cytidylate kinase-like family PI3Ka PF00613.20 ELR25608.1 - 4.1e-16 58.9 0.0 5.5e-16 58.5 0.0 1.2 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) THUMP PF02926.17 ELR25609.1 - 6.7e-08 32.7 0.0 1.2e-07 31.9 0.0 1.4 1 0 0 1 1 1 1 THUMP domain UPF0020 PF01170.18 ELR25609.1 - 6.6e-06 25.9 0.1 1e-05 25.3 0.1 1.3 1 0 0 1 1 1 1 Putative RNA methylase family UPF0020 TFIIA PF03153.13 ELR25610.1 - 0.95 9.4 23.4 1.3 8.9 23.4 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit F-box PF00646.33 ELR25611.1 - 0.00019 21.2 0.4 0.00031 20.5 0.4 1.4 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 ELR25611.1 - 0.0016 18.3 0.5 0.0026 17.6 0.5 1.3 1 0 0 1 1 1 1 F-box-like CENP-H PF05837.12 ELR25612.1 - 0.079 13.4 3.4 0.12 12.8 3.4 1.3 1 0 0 1 1 1 0 Centromere protein H (CENP-H) SET PF00856.28 ELR25614.1 - 2.3e-10 41.1 0.0 3.3e-10 40.6 0.0 1.2 1 0 0 1 1 1 1 SET domain SAF PF08666.12 ELR25614.1 - 0.044 14.4 0.0 0.5 11.0 0.0 2.1 2 0 0 2 2 2 0 SAF domain Sacchrp_dh_C PF16653.5 ELR25615.1 - 1.1e-27 97.9 0.0 1.6e-27 97.3 0.0 1.2 1 0 0 1 1 1 1 Saccharopine dehydrogenase C-terminal domain Sacchrp_dh_NADP PF03435.18 ELR25615.1 - 8.5e-22 77.8 0.0 1.1e-21 77.4 0.0 1.2 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain Shikimate_DH PF01488.20 ELR25615.1 - 4.3e-08 33.3 0.0 8.5e-08 32.4 0.0 1.4 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase NAD_binding_2 PF03446.15 ELR25615.1 - 0.00034 20.8 0.0 0.00043 20.5 0.0 1.1 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_10 PF13460.6 ELR25615.1 - 0.0025 17.7 0.0 0.0033 17.3 0.0 1.3 1 1 0 1 1 1 1 NAD(P)H-binding XdhC_C PF13478.6 ELR25615.1 - 0.021 15.3 0.1 0.027 15.0 0.1 1.3 1 0 0 1 1 1 0 XdhC Rossmann domain adh_short PF00106.25 ELR25615.1 - 0.027 13.9 0.0 0.28 10.6 0.1 2.0 2 0 0 2 2 2 0 short chain dehydrogenase Epimerase PF01370.21 ELR25615.1 - 0.07 12.6 0.0 0.082 12.3 0.0 1.2 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family GFO_IDH_MocA PF01408.22 ELR25615.1 - 0.13 13.1 0.0 0.19 12.6 0.0 1.3 1 0 0 1 1 1 0 Oxidoreductase family, NAD-binding Rossmann fold UDPG_MGDP_dh_N PF03721.14 ELR25615.1 - 0.15 11.7 0.1 1.5 8.4 0.0 2.0 2 0 0 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain CREPT PF16566.5 ELR25616.1 - 0.038 14.2 0.3 0.054 13.7 0.3 1.2 1 0 0 1 1 1 0 Cell-cycle alteration and expression-elevated protein in tumour rRNA_proc-arch PF13234.6 ELR25616.1 - 0.11 12.4 0.2 0.16 11.9 0.2 1.2 1 0 0 1 1 1 0 rRNA-processing arch domain MIS13 PF08202.11 ELR25616.1 - 0.11 11.8 0.0 0.14 11.4 0.0 1.1 1 0 0 1 1 1 0 Mis12-Mtw1 protein family CLZ PF16526.5 ELR25616.1 - 0.12 12.7 0.7 0.24 11.8 0.7 1.4 1 0 0 1 1 1 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels NPV_P10 PF05531.12 ELR25616.1 - 0.14 12.6 0.3 0.21 12.1 0.3 1.2 1 0 0 1 1 1 0 Nucleopolyhedrovirus P10 protein AT_hook PF02178.19 ELR25616.1 - 6.4 7.0 12.2 1.4 9.1 7.8 2.4 2 0 0 2 2 2 0 AT hook motif DUF16 PF01519.16 ELR25617.1 - 0.081 13.4 0.3 0.096 13.2 0.3 1.2 1 0 0 1 1 1 0 Protein of unknown function DUF16 KCH PF16944.5 ELR25618.1 - 0.075 12.8 0.0 0.09 12.5 0.0 1.1 1 0 0 1 1 1 0 Fungal potassium channel PAS_9 PF13426.7 ELR25620.1 - 5.1e-06 26.7 0.0 1.3e-05 25.3 0.0 1.6 1 0 0 1 1 1 1 PAS domain PAS PF00989.25 ELR25620.1 - 4.2e-05 23.5 0.0 4.2e-05 23.5 0.0 2.7 3 0 0 3 3 3 1 PAS fold PAS_3 PF08447.12 ELR25620.1 - 5.8e-05 23.3 0.7 8.7e-05 22.7 0.0 1.7 2 0 0 2 2 2 1 PAS fold Zn_clus PF00172.18 ELR25620.1 - 0.017 15.3 8.6 0.032 14.4 8.6 1.4 1 0 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain AT_hook PF02178.19 ELR25620.1 - 0.26 11.3 4.9 0.99 9.5 4.9 1.9 1 0 0 1 1 1 0 AT hook motif Takusan PF04822.13 ELR25621.1 - 0.024 14.5 0.2 0.055 13.4 0.2 1.6 1 0 0 1 1 1 0 Takusan PAS_9 PF13426.7 ELR25621.1 - 0.055 13.7 0.0 0.2 11.9 0.0 1.8 2 0 0 2 2 2 0 PAS domain PAS_3 PF08447.12 ELR25621.1 - 0.063 13.6 0.0 0.53 10.6 0.0 2.2 1 1 0 1 1 1 0 PAS fold RmuC PF02646.16 ELR25621.1 - 0.073 12.2 2.1 0.11 11.7 2.1 1.1 1 0 0 1 1 1 0 RmuC family TPR_MLP1_2 PF07926.12 ELR25621.1 - 0.13 12.4 1.8 0.2 11.7 1.8 1.2 1 0 0 1 1 1 0 TPR/MLP1/MLP2-like protein DUF1640 PF07798.11 ELR25621.1 - 0.13 12.3 0.6 0.2 11.7 0.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1640) BLOC1_2 PF10046.9 ELR25621.1 - 0.19 12.0 1.2 0.31 11.4 1.2 1.3 1 0 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DivIC PF04977.15 ELR25621.1 - 0.75 9.6 3.2 0.88 9.4 0.9 1.9 1 1 1 2 2 2 0 Septum formation initiator ZapB PF06005.12 ELR25621.1 - 2.1 8.8 4.7 5 7.6 4.7 1.6 1 1 0 1 1 1 0 Cell division protein ZapB Tmemb_cc2 PF10267.9 ELR25622.1 - 0.012 14.8 0.1 0.016 14.4 0.1 1.1 1 0 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein UPF0242 PF06785.11 ELR25622.1 - 0.019 15.1 0.5 0.026 14.6 0.5 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus AT_hook PF02178.19 ELR25622.1 - 0.024 14.5 3.9 0.084 12.8 3.9 2.0 1 0 0 1 1 1 0 AT hook motif Cnn_1N PF07989.11 ELR25622.1 - 0.026 14.7 4.2 0.041 14.0 4.2 1.3 1 0 0 1 1 1 0 Centrosomin N-terminal motif 1 ZapB PF06005.12 ELR25622.1 - 0.079 13.4 8.2 0.13 12.7 8.2 1.3 1 0 0 1 1 1 0 Cell division protein ZapB YabA PF06156.13 ELR25622.1 - 0.12 13.1 5.7 0.18 12.5 5.7 1.2 1 0 0 1 1 1 0 Initiation control protein YabA PAS_9 PF13426.7 ELR25623.1 - 0.00014 22.0 0.0 0.0003 21.0 0.0 1.6 1 0 0 1 1 1 1 PAS domain Zn_clus PF00172.18 ELR25623.1 - 0.00015 21.8 10.8 0.0003 20.8 10.8 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain PAS PF00989.25 ELR25623.1 - 0.0015 18.5 0.1 0.047 13.7 0.0 2.4 2 0 0 2 2 2 1 PAS fold AT_hook PF02178.19 ELR25623.1 - 0.03 14.2 1.4 0.088 12.7 1.4 1.9 1 0 0 1 1 1 0 AT hook motif PAS_8 PF13188.7 ELR25623.1 - 0.19 11.8 0.0 0.82 9.8 0.0 2.0 2 0 0 2 2 2 0 PAS domain Peptidase_M16_M PF16187.5 ELR25624.1 - 7.8e-98 327.2 0.2 1.1e-97 326.7 0.2 1.3 1 0 0 1 1 1 1 Middle or third domain of peptidase_M16 Peptidase_M16 PF00675.20 ELR25624.1 - 1.2e-28 99.9 4.4 3.3e-26 92.1 0.9 3.8 3 1 0 3 3 3 2 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.21 ELR25624.1 - 1.2e-27 97.1 0.1 1.9e-12 47.6 0.0 3.2 3 0 0 3 3 3 2 Peptidase M16 inactive domain COQ7 PF03232.13 ELR25625.1 - 0.11 12.2 0.0 0.14 12.0 0.0 1.1 1 0 0 1 1 1 0 Ubiquinone biosynthesis protein COQ7 SBDS PF01172.18 ELR25625.1 - 0.17 12.0 0.0 0.23 11.5 0.0 1.2 1 0 0 1 1 1 0 Shwachman-Bodian-Diamond syndrome (SBDS) protein Acyltransferase PF01553.21 ELR25626.1 - 3e-22 78.7 0.0 4.1e-22 78.3 0.0 1.1 1 0 0 1 1 1 1 Acyltransferase MFS_1 PF07690.16 ELR25627.1 - 2.5e-17 62.9 39.4 9e-09 34.7 13.2 2.5 1 1 0 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 ELR25627.1 - 2.5e-07 29.6 31.5 9.9e-06 24.4 0.6 4.1 2 2 2 4 4 4 3 MFS/sugar transport protein BT1 PF03092.16 ELR25627.1 - 1.5 7.0 14.5 0.0078 14.5 3.1 2.7 2 2 0 2 2 2 0 BT1 family Usp PF00582.26 ELR25628.1 - 5.4e-25 88.5 0.1 6.6e-25 88.3 0.1 1.1 1 0 0 1 1 1 1 Universal stress protein family Alpha-amylase PF00128.24 ELR25629.1 - 1.5e-16 60.9 0.0 3.7e-14 53.1 0.0 2.9 1 1 0 1 1 1 1 Alpha amylase, catalytic domain hDGE_amylase PF14701.6 ELR25629.1 - 0.071 12.2 0.0 0.11 11.6 0.0 1.2 1 0 0 1 1 1 0 Glycogen debranching enzyme, glucanotransferase domain UCR_UQCRX_QCR9 PF05365.12 ELR25630.1 - 2.7e-06 27.2 1.2 7.4e-06 25.8 0.7 1.8 1 1 1 2 2 2 1 Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like HEAT PF02985.22 ELR25631.1 - 1.2e-41 137.2 21.7 0.001 19.1 0.0 13.3 13 0 0 13 13 13 10 HEAT repeat HEAT_2 PF13646.6 ELR25631.1 - 2.1e-36 124.2 3.8 1.8e-09 37.9 0.0 6.8 3 2 3 6 6 6 6 HEAT repeats Vac14_Fab1_bd PF12755.7 ELR25631.1 - 8.1e-14 52.0 4.1 0.0051 17.4 0.1 6.1 3 1 2 6 6 6 3 Vacuolar 14 Fab1-binding region HEAT_EZ PF13513.6 ELR25631.1 - 3.5e-12 46.5 2.7 0.0069 16.9 0.0 6.3 7 2 1 8 8 8 2 HEAT-like repeat Adaptin_N PF01602.20 ELR25631.1 - 3.2e-11 42.5 6.8 0.013 14.1 0.1 4.0 3 1 0 4 4 4 3 Adaptin N terminal region RTP1_C1 PF10363.9 ELR25631.1 - 1.5e-07 31.6 3.9 0.79 9.9 0.0 4.6 4 1 0 4 4 4 3 Required for nuclear transport of RNA pol II C-terminus 1 Cnd1 PF12717.7 ELR25631.1 - 7.3e-07 29.4 11.1 0.16 12.0 0.3 4.7 3 1 0 4 4 4 2 non-SMC mitotic condensation complex subunit 1 Arm PF00514.23 ELR25631.1 - 3.8e-06 26.7 2.9 0.31 11.2 0.0 6.6 8 0 0 8 8 8 1 Armadillo/beta-catenin-like repeat IFRD PF05004.13 ELR25631.1 - 3.5e-05 23.1 1.2 0.042 12.9 0.1 3.9 3 1 1 4 4 4 2 Interferon-related developmental regulator (IFRD) CLASP_N PF12348.8 ELR25631.1 - 0.00054 19.6 1.3 0.031 13.9 0.0 3.7 1 1 2 4 4 4 1 CLASP N terminal DNA_alkylation PF08713.11 ELR25631.1 - 0.0067 16.2 0.4 0.41 10.3 0.0 3.3 1 1 3 4 4 4 2 DNA alkylation repair enzyme Ecm29 PF13001.7 ELR25631.1 - 0.051 12.3 6.1 0.29 9.8 0.3 4.0 3 2 1 5 5 5 0 Proteasome stabiliser YukD PF08817.10 ELR25631.1 - 0.081 13.6 1.7 7.6 7.3 0.0 3.7 3 1 1 4 4 3 0 WXG100 protein secretion system (Wss), protein YukD RBM39linker PF15519.6 ELR25631.1 - 0.11 13.6 0.1 0.26 12.4 0.1 1.6 1 0 0 1 1 1 0 linker between RRM2 and RRM3 domains in RBM39 protein RasGEF PF00617.19 ELR25633.1 - 2.4e-13 50.7 0.0 7.1e-13 49.1 0.0 1.7 1 1 0 1 1 1 1 RasGEF domain RasGEF PF00617.19 ELR25634.1 - 2.3e-14 54.0 0.0 4.7e-14 53.0 0.0 1.5 1 0 0 1 1 1 1 RasGEF domain F-box-like PF12937.7 ELR25634.1 - 9.6e-08 31.8 0.0 4.4e-07 29.7 0.0 2.3 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ELR25634.1 - 0.014 15.3 0.0 0.029 14.3 0.0 1.5 1 0 0 1 1 1 0 F-box domain RR_TM4-6 PF06459.12 ELR25634.1 - 5.9 6.6 6.4 7.6 6.3 5.2 1.6 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 U-box PF04564.15 ELR25635.1 - 4.1e-20 71.7 0.1 1.1e-19 70.3 0.0 1.8 2 0 0 2 2 1 1 U-box domain zf-C3HC4_3 PF13920.6 ELR25635.1 - 3.4e-07 30.0 10.6 6e-07 29.2 10.6 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 ELR25635.1 - 0.00048 19.9 10.7 0.00096 19.0 10.7 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 ELR25635.1 - 0.00079 19.7 10.5 0.0015 18.8 10.5 1.5 1 0 0 1 1 1 1 Ring finger domain Prok-RING_4 PF14447.6 ELR25635.1 - 0.015 15.2 10.1 0.036 13.9 10.1 1.6 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.6 ELR25635.1 - 0.017 15.3 4.6 0.017 15.3 4.6 2.7 4 0 0 4 4 4 0 zinc finger of C3HC4-type, RING zf-RING_4 PF14570.6 ELR25635.1 - 0.021 14.6 6.7 0.05 13.4 6.7 1.6 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-RING_5 PF14634.6 ELR25635.1 - 0.061 13.3 15.3 0.058 13.4 13.5 1.9 1 1 1 2 2 2 0 zinc-RING finger domain zf-C3HC4_2 PF13923.6 ELR25635.1 - 0.94 9.4 12.0 5.5 6.9 12.0 2.2 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Ndc1_Nup PF09531.10 ELR25635.1 - 1.2 7.7 3.1 1.5 7.4 3.1 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup zf-RING_UBOX PF13445.6 ELR25635.1 - 1.9 8.6 10.4 0.56 10.3 6.6 2.1 2 0 0 2 2 2 0 RING-type zinc-finger PI-PLC-C1 PF16670.5 ELR25636.1 - 2.7e-06 26.7 0.0 2e-05 23.8 0.0 2.1 2 0 0 2 2 2 1 Phosphoinositide phospholipase C, Ca2+-dependent PEHE PF15275.6 ELR25637.1 - 6.6e-08 33.3 0.0 6.6e-08 33.3 0.0 2.8 3 0 0 3 3 3 1 PEHE domain SURF2 PF05477.11 ELR25637.1 - 1.7 8.2 9.1 0.28 10.9 1.7 2.6 3 0 0 3 3 3 0 Surfeit locus protein 2 (SURF2) CarboxypepD_reg PF13620.6 ELR25638.1 - 1.5e-52 175.8 24.5 1e-09 38.5 0.6 9.7 10 1 0 10 10 9 8 Carboxypeptidase regulatory-like domain SdrD_B PF17210.3 ELR25638.1 - 1.4e-27 96.1 9.0 2.6e-07 30.9 0.2 8.0 8 0 0 8 8 8 6 SdrD B-like domain CarbopepD_reg_2 PF13715.6 ELR25638.1 - 7.5e-25 86.8 8.0 0.00023 21.1 0.1 8.5 7 1 1 8 8 8 5 CarboxypepD_reg-like domain DUF2012 PF09430.10 ELR25638.1 - 4.7e-21 75.2 2.8 0.00036 20.6 0.0 7.8 4 3 4 8 8 8 4 Protein of unknown function (DUF2012) SpaA PF17802.1 ELR25638.1 - 3.6e-20 72.1 8.8 0.00052 20.3 0.0 6.8 4 1 0 5 5 5 5 Prealbumin-like fold domain fn3_3 PF14686.6 ELR25638.1 - 1.5e-11 43.9 2.3 0.13 12.0 0.0 6.5 6 0 0 6 6 6 4 Polysaccharide lyase family 4, domain II DUF3823 PF12866.7 ELR25638.1 - 2.5e-07 30.9 0.1 0.00027 21.2 0.0 3.6 3 1 0 3 3 3 1 Protein of unknown function (DUF3823) N-terminal domain Big_1 PF02369.16 ELR25638.1 - 1.2e-05 25.2 16.2 0.00027 20.9 0.4 5.7 5 0 0 5 5 5 2 Bacterial Ig-like domain (group 1) Dioxygenase_C PF00775.21 ELR25638.1 - 3e-05 23.6 1.8 16 4.8 0.0 5.5 4 2 2 6 6 6 0 Dioxygenase MetallophosN PF16371.5 ELR25638.1 - 0.00047 20.4 7.0 0.41 10.9 1.1 5.1 4 1 0 4 4 4 1 N terminal of Calcineurin-like phosphoesterase fn3 PF00041.21 ELR25638.1 - 0.0011 19.2 0.8 0.023 15.0 0.0 3.5 4 0 0 4 4 4 1 Fibronectin type III domain TTR-52 PF01060.23 ELR25638.1 - 0.0015 19.2 0.0 19 6.0 0.0 6.1 8 0 0 8 8 8 0 Transthyretin-like family EMP24_GP25L PF01105.24 ELR25638.1 - 0.092 12.7 0.2 1.3 8.9 0.0 3.0 3 1 0 3 3 3 0 emp24/gp25L/p24 family/GOLD DUF4198 PF10670.9 ELR25638.1 - 0.1 13.0 5.6 25 5.2 0.0 5.1 5 1 0 5 5 4 0 Domain of unknown function (DUF4198) phage_tail_N PF08400.10 ELR25638.1 - 0.1 12.6 0.1 5.1 7.1 0.2 2.9 3 0 0 3 3 3 0 Prophage tail fibre N-terminal Invasin_D3 PF09134.10 ELR25638.1 - 0.13 12.6 0.1 0.13 12.6 0.1 4.1 4 0 0 4 4 3 0 Invasin, domain 3 Ribosomal_L31e PF01198.19 ELR25639.1 - 2.8e-43 146.0 0.4 3.6e-43 145.7 0.4 1.1 1 0 0 1 1 1 1 Ribosomal protein L31e Ribonuc_red_lgC PF02867.15 ELR25641.1 - 1.9e-190 633.9 0.0 2.4e-190 633.6 0.0 1.1 1 0 0 1 1 1 1 Ribonucleotide reductase, barrel domain Ribonuc_red_lgN PF00317.21 ELR25641.1 - 4.1e-24 84.4 0.0 1.2e-23 82.9 0.0 1.9 1 0 0 1 1 1 1 Ribonucleotide reductase, all-alpha domain ATP-cone PF03477.16 ELR25641.1 - 3.1e-11 43.7 0.0 9.1e-11 42.2 0.0 1.9 1 0 0 1 1 1 1 ATP cone domain HEAT_2 PF13646.6 ELR25642.1 - 4.1e-05 23.9 0.1 0.068 13.6 0.0 3.4 2 1 0 2 2 2 2 HEAT repeats HEAT PF02985.22 ELR25642.1 - 0.0055 16.9 0.1 0.13 12.6 0.0 3.4 2 0 0 2 2 2 1 HEAT repeat TFIIA PF03153.13 ELR25642.1 - 0.016 15.2 4.8 0.024 14.6 4.8 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit HEAT_EZ PF13513.6 ELR25642.1 - 0.029 14.9 0.2 0.77 10.3 0.0 3.4 2 0 0 2 2 2 0 HEAT-like repeat Vac14_Fab1_bd PF12755.7 ELR25642.1 - 0.065 13.8 0.0 0.14 12.7 0.0 1.5 1 0 0 1 1 1 0 Vacuolar 14 Fab1-binding region CDC45 PF02724.14 ELR25642.1 - 0.3 9.3 3.9 0.48 8.7 3.9 1.2 1 0 0 1 1 1 0 CDC45-like protein Afi1 PF07792.12 ELR25642.1 - 3.7 8.1 7.4 45 4.5 4.6 2.5 2 0 0 2 2 2 0 Docking domain of Afi1 for Arf3 in vesicle trafficking BTB PF00651.31 ELR25643.1 - 1.5e-11 44.5 0.0 2.6e-11 43.7 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain HEPN_Swt1 PF18731.1 ELR25643.1 - 0.13 12.6 0.0 0.22 11.9 0.0 1.3 1 0 0 1 1 1 0 Swt1-like HEPN CUE PF02845.16 ELR25644.1 - 1.6e-06 27.7 0.0 3.7e-06 26.5 0.0 1.6 1 0 0 1 1 1 1 CUE domain Ribosomal_60s PF00428.19 ELR25644.1 - 0.026 15.1 1.7 0.026 15.1 1.7 3.9 4 0 0 4 4 4 0 60s Acidic ribosomal protein CDC45 PF02724.14 ELR25644.1 - 0.28 9.4 4.0 0.44 8.8 4.0 1.2 1 0 0 1 1 1 0 CDC45-like protein FAM176 PF14851.6 ELR25644.1 - 4.8 6.8 6.9 7.6 6.2 0.0 2.7 3 0 0 3 3 3 0 FAM176 family FKBP_C PF00254.28 ELR25645.1 - 1.9e-29 101.8 0.1 2.4e-29 101.5 0.1 1.1 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase FKBP_N_2 PF18023.1 ELR25645.1 - 0.027 14.6 0.0 0.15 12.2 0.0 1.9 1 1 0 1 1 1 0 BDBT FKBP like N-terminal Arm PF00514.23 ELR25646.1 - 1.9e-46 154.7 12.7 1.9e-09 37.3 0.0 12.2 10 2 3 13 13 13 8 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.6 ELR25646.1 - 4.6e-14 52.6 22.1 0.0011 19.3 0.0 7.4 4 3 3 7 7 7 5 HEAT repeats V-ATPase_H_N PF03224.14 ELR25646.1 - 1.6e-11 44.1 1.0 0.06 12.6 0.0 4.5 1 1 3 4 4 4 4 V-ATPase subunit H Adaptin_N PF01602.20 ELR25646.1 - 3.2e-11 42.5 8.7 1e-06 27.6 2.6 4.1 1 1 2 3 3 3 2 Adaptin N terminal region Arm_2 PF04826.13 ELR25646.1 - 2.4e-10 40.3 7.7 2.2e-05 24.0 0.2 4.8 3 2 2 5 5 5 3 Armadillo-like DUF3361 PF11841.8 ELR25646.1 - 1.3e-07 31.7 6.7 0.0042 17.1 0.1 5.2 3 1 2 5 5 5 1 Domain of unknown function (DUF3361) HEAT_EZ PF13513.6 ELR25646.1 - 6.1e-07 29.8 17.4 2.2 8.9 0.0 8.0 8 0 0 8 8 8 2 HEAT-like repeat V-ATPase_H_C PF11698.8 ELR25646.1 - 5.9e-05 23.2 6.3 0.42 10.7 0.2 5.5 1 1 7 8 8 8 1 V-ATPase subunit H Cnd1 PF12717.7 ELR25646.1 - 0.00048 20.2 6.3 0.2 11.7 0.4 3.1 3 1 0 3 3 3 2 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.22 ELR25646.1 - 0.00063 19.8 15.5 6 7.4 0.0 8.9 11 1 0 11 11 11 1 HEAT repeat Mo25 PF08569.11 ELR25646.1 - 0.0027 17.1 2.4 0.092 12.1 0.7 2.8 1 1 0 2 2 2 1 Mo25-like U3snoRNP10 PF12397.8 ELR25646.1 - 0.0027 18.1 2.2 1 9.7 0.1 4.0 2 1 0 3 3 3 1 U3 small nucleolar RNA-associated protein 10 RTP1_C1 PF10363.9 ELR25646.1 - 0.0029 17.8 6.2 0.45 10.7 0.1 4.3 3 2 1 4 4 4 1 Required for nuclear transport of RNA pol II C-terminus 1 Proteasom_PSMB PF10508.9 ELR25646.1 - 0.0038 15.8 11.6 0.13 10.7 0.0 3.9 2 1 2 4 4 4 1 Proteasome non-ATPase 26S subunit Ric8 PF10165.9 ELR25646.1 - 0.042 12.9 3.5 0.68 8.9 0.2 2.9 3 1 0 3 3 3 0 Guanine nucleotide exchange factor synembryn SIL1 PF16782.5 ELR25646.1 - 0.053 12.7 3.8 0.12 11.5 0.5 2.7 2 1 1 3 3 3 0 Nucleotide exchange factor SIL1 Aminotran_1_2 PF00155.21 ELR25647.1 - 3.9e-81 273.0 0.0 4.6e-81 272.8 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Ras PF00071.22 ELR25649.1 - 1.1e-51 174.6 0.0 1.5e-51 174.3 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ELR25649.1 - 1.5e-23 83.3 0.0 2.3e-23 82.7 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ELR25649.1 - 5.7e-06 25.9 0.0 8e-06 25.4 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 ELR25649.1 - 0.037 13.5 0.0 0.12 12.0 0.0 1.7 1 1 1 2 2 2 0 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 ELR25649.1 - 0.11 12.6 0.0 0.19 11.8 0.0 1.5 1 0 0 1 1 1 0 50S ribosome-binding GTPase F-box-like PF12937.7 ELR25650.1 - 5.1e-07 29.5 0.3 2.8e-06 27.1 0.2 2.3 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 ELR25650.1 - 0.022 14.6 0.2 0.08 12.8 0.0 2.0 2 0 0 2 2 2 0 F-box domain CDC45 PF02724.14 ELR25650.1 - 2.2 6.5 12.2 3.1 6.0 12.2 1.2 1 0 0 1 1 1 0 CDC45-like protein ALMT PF11744.8 ELR25650.1 - 3.7 6.3 4.3 5 5.9 4.3 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter RPA_C PF08784.11 ELR25651.1 - 1.1e-08 35.6 0.0 1.2e-08 35.5 0.0 1.0 1 0 0 1 1 1 1 Replication protein A C terminal DUF2059 PF09832.9 ELR25651.1 - 0.08 13.0 0.0 0.14 12.2 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2059) W2 PF02020.18 ELR25652.1 - 9.2e-20 70.6 0.4 9.2e-20 70.6 0.4 2.5 4 0 0 4 4 4 1 eIF4-gamma/eIF5/eIF2-epsilon Hexapep PF00132.24 ELR25652.1 - 6.2e-08 32.1 15.1 3.9e-06 26.4 5.0 4.3 1 1 2 3 3 3 2 Bacterial transferase hexapeptide (six repeats) DUF4954 PF16314.5 ELR25652.1 - 0.012 13.7 2.7 0.018 13.2 1.1 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4954) Fucokinase PF07959.12 ELR25652.1 - 0.11 11.4 0.3 0.29 10.0 0.3 1.5 1 1 0 1 1 1 0 L-fucokinase Hexapep_2 PF14602.6 ELR25652.1 - 0.13 12.0 6.8 0.57 10.0 1.1 3.4 3 0 0 3 3 3 0 Hexapeptide repeat of succinyl-transferase PCI PF01399.27 ELR25653.1 - 1.2e-07 32.2 0.1 3.4e-07 30.7 0.0 1.8 2 0 0 2 2 2 1 PCI domain CSN7a_helixI PF18392.1 ELR25653.1 - 3.2e-05 23.8 1.1 5.7e-05 22.9 1.1 1.4 1 0 0 1 1 1 1 COP9 signalosome complex subunit 7a helix I domain DUF4996 PF16387.5 ELR25653.1 - 0.12 12.8 0.1 0.38 11.3 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function RRM_1 PF00076.22 ELR25655.1 - 3.5e-11 42.8 0.0 6.7e-11 41.9 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) TAF4 PF05236.14 ELR25655.1 - 0.28 10.9 20.3 0.69 9.6 20.3 1.7 1 0 0 1 1 1 0 Transcription initiation factor TFIID component TAF4 family PA26 PF04636.13 ELR25655.1 - 2.9 6.7 8.9 4.1 6.2 8.9 1.1 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Peptidase_S28 PF05577.12 ELR25656.1 - 1.7e-39 135.9 1.2 4.3e-38 131.2 1.2 2.0 1 1 0 1 1 1 1 Serine carboxypeptidase S28 DUF3589 PF12141.8 ELR25656.1 - 0.037 12.6 0.0 0.051 12.2 0.0 1.1 1 0 0 1 1 1 0 Beta-mannosyltransferases DUF5605 PF18310.1 ELR25656.1 - 0.049 13.5 0.4 3.5 7.6 0.1 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF5605) FGE-sulfatase PF03781.16 ELR25657.1 - 2.2e-30 106.1 3.2 4.1e-30 105.2 3.2 1.4 1 0 0 1 1 1 1 Sulfatase-modifying factor enzyme 1 Methyltransf_31 PF13847.6 ELR25657.1 - 4.6e-11 42.7 0.0 8.4e-07 28.9 0.0 2.3 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_12 PF08242.12 ELR25657.1 - 4.6e-07 30.5 0.0 5.1e-06 27.2 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain DinB_2 PF12867.7 ELR25657.1 - 7.8e-07 29.7 0.1 1.7e-06 28.5 0.1 1.6 1 0 0 1 1 1 1 DinB superfamily Methyltransf_25 PF13649.6 ELR25657.1 - 1.5e-06 28.8 0.0 8e-05 23.3 0.0 2.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ELR25657.1 - 5.1e-06 27.1 0.0 2.1e-05 25.1 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 ELR25657.1 - 1.1e-05 25.3 0.0 2.2e-05 24.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 ELR25657.1 - 0.17 11.2 0.0 0.35 10.1 0.0 1.5 1 1 0 1 1 1 0 ubiE/COQ5 methyltransferase family Dynamin_N PF00350.23 ELR25658.1 - 8.5e-08 32.4 0.0 1.2e-07 31.9 0.0 1.3 1 0 0 1 1 1 1 Dynamin family MMR_HSR1 PF01926.23 ELR25658.1 - 0.00092 19.3 0.0 0.002 18.2 0.0 1.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 ELR25658.1 - 0.043 13.7 0.0 0.065 13.1 0.0 1.4 1 0 0 1 1 1 0 RsgA GTPase ABC_tran PF00005.27 ELR25658.1 - 0.12 12.9 0.0 0.2 12.2 0.0 1.3 1 0 0 1 1 1 0 ABC transporter STAT1_TAZ2bind PF12162.8 ELR25658.1 - 0.34 10.5 1.3 1.6 8.4 0.4 2.3 2 0 0 2 2 2 0 STAT1 TAZ2 binding domain Pkinase PF00069.25 ELR25659.1 - 1.2e-14 54.4 0.2 2.5e-14 53.3 0.1 1.6 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR25659.1 - 8.5e-06 25.2 0.0 1.1e-05 24.9 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 ELR25659.1 - 0.00025 21.1 0.2 0.00056 19.9 0.2 1.6 1 0 0 1 1 1 1 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 ELR25659.1 - 0.003 16.4 0.0 0.0036 16.1 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase Choline_kinase PF01633.20 ELR25659.1 - 0.01 15.4 0.0 0.023 14.3 0.0 1.5 1 0 0 1 1 1 0 Choline/ethanolamine kinase Seadorna_VP7 PF07387.11 ELR25659.1 - 0.016 14.3 0.0 0.025 13.6 0.0 1.3 1 0 0 1 1 1 0 Seadornavirus VP7 RIO1 PF01163.22 ELR25659.1 - 0.19 11.3 0.0 0.32 10.6 0.0 1.3 1 0 0 1 1 1 0 RIO1 family T5orf172 PF10544.9 ELR25660.1 - 8.2e-15 55.2 0.0 6.4e-14 52.3 0.0 2.3 2 0 0 2 2 2 1 T5orf172 domain MUG113 PF13455.6 ELR25660.1 - 2.1e-09 37.9 0.1 2.2e-08 34.7 0.0 2.3 2 0 0 2 2 2 1 Meiotically up-regulated gene 113 CTD_bind PF04818.13 ELR25660.1 - 0.085 13.7 3.7 0.13 13.1 0.2 3.1 4 0 0 4 4 4 0 RNA polymerase II-binding domain. eIF3_subunit PF08597.10 ELR25660.1 - 0.17 11.8 0.1 0.28 11.0 0.1 1.3 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit zf-C2H2 PF00096.26 ELR25661.1 - 1.1e-05 25.6 0.1 1.9e-05 24.8 0.1 1.4 1 0 0 1 1 1 1 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 ELR25661.1 - 0.0034 18.1 0.2 0.0057 17.4 0.2 1.4 1 0 0 1 1 1 1 C2H2-type zinc finger zf-H2C2_2 PF13465.6 ELR25661.1 - 1.5 9.4 5.1 1.1 9.8 0.3 2.3 2 0 0 2 2 2 0 Zinc-finger double domain WD40 PF00400.32 ELR25662.1 - 1.9e-06 28.5 11.4 0.011 16.6 0.1 4.5 4 2 0 4 4 4 3 WD domain, G-beta repeat SPX PF03105.19 ELR25662.1 - 0.00063 19.8 3.2 0.00071 19.6 3.2 1.1 1 0 0 1 1 1 1 SPX domain Apt1 PF10351.9 ELR25662.1 - 0.01 14.7 2.4 0.011 14.7 2.4 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain Secretin_N_2 PF07655.13 ELR25662.1 - 0.016 15.7 18.9 0.032 14.8 13.5 2.5 2 0 0 2 2 2 0 Secretin N-terminal domain Macoilin PF09726.9 ELR25662.1 - 0.018 13.6 3.1 0.018 13.6 3.1 1.2 1 0 0 1 1 1 0 Macoilin family Sporozoite_P67 PF05642.11 ELR25662.1 - 0.076 11.1 5.8 0.08 11.0 5.8 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen PagP PF07017.11 ELR25662.1 - 0.19 11.2 0.5 20 4.6 0.1 2.8 3 1 0 3 3 3 0 Antimicrobial peptide resistance and lipid A acylation protein PagP Nup160 PF11715.8 ELR25662.1 - 0.32 9.6 8.3 0.3 9.7 6.0 1.8 1 1 0 2 2 2 0 Nucleoporin Nup120/160 AF-4 PF05110.13 ELR25662.1 - 4.6 5.2 25.4 5.6 4.9 25.4 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein DUF4614 PF15391.6 ELR25662.1 - 6.1 6.8 16.0 11 5.9 16.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4614) LIM PF00412.22 ELR25664.1 - 3.8e-31 107.1 24.4 8.4e-13 48.4 2.2 5.2 4 2 0 4 4 4 4 LIM domain zinc-ribbons_6 PF07191.12 ELR25664.1 - 0.032 14.2 18.6 0.12 12.4 5.2 3.7 1 1 2 3 3 3 0 zinc-ribbons zinc_ribbon_9 PF14369.6 ELR25664.1 - 1.3 9.4 12.4 1.1 9.6 0.4 4.2 4 0 0 4 4 4 0 zinc-ribbon RasGEF PF00617.19 ELR25666.1 - 3.7e-52 177.1 0.5 5.3e-52 176.6 0.5 1.2 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 ELR25667.1 - 3.1e-19 69.2 0.0 6.5e-19 68.1 0.0 1.6 1 0 0 1 1 1 1 RasGEF N-terminal motif PDEase_I PF00233.19 ELR25668.1 - 2.2e-71 240.4 0.0 2.8e-71 240.0 0.0 1.1 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase LRR_6 PF13516.6 ELR25669.1 - 0.00014 21.6 0.1 0.0011 18.8 0.0 2.5 2 0 0 2 2 2 1 Leucine Rich repeat DUF1884 PF08967.10 ELR25669.1 - 0.099 12.9 0.1 0.32 11.3 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF1884) Aa_trans PF01490.18 ELR25670.1 - 5.4e-60 203.2 27.4 6.3e-60 203.0 26.8 1.3 1 1 0 1 1 1 1 Transmembrane amino acid transporter protein Costars PF14705.6 ELR25672.1 - 2.1e-18 66.3 0.0 4.1e-18 65.3 0.0 1.5 1 0 0 1 1 1 1 Costars LIM PF00412.22 ELR25672.1 - 6.9e-07 29.4 4.1 1.3e-06 28.5 4.1 1.5 1 0 0 1 1 1 1 LIM domain BTB PF00651.31 ELR25674.1 - 0.099 12.9 0.0 0.15 12.3 0.0 1.3 1 0 0 1 1 1 0 BTB/POZ domain RhoGEF PF00621.20 ELR25676.1 - 6e-46 157.0 0.1 1.9e-45 155.3 0.1 1.9 1 0 0 1 1 1 1 RhoGEF domain PH PF00169.29 ELR25676.1 - 0.00021 21.8 0.2 0.0011 19.5 0.2 2.2 1 1 0 1 1 1 1 PH domain HD_6 PF18019.1 ELR25676.1 - 0.056 13.6 0.0 0.14 12.3 0.0 1.7 1 0 0 1 1 1 0 HD domain CENP-B_dimeris PF09026.10 ELR25676.1 - 0.22 11.9 9.0 0.9 10.0 9.0 2.1 1 0 0 1 1 1 0 Centromere protein B dimerisation domain DegQ PF08181.11 ELR25676.1 - 5.8 7.1 10.0 6.1 7.0 0.2 4.5 4 0 0 4 4 4 0 DegQ (SacQ) family Branch PF02485.21 ELR25678.1 - 1.9e-26 93.0 0.0 2.5e-26 92.7 0.0 1.1 1 0 0 1 1 1 1 Core-2/I-Branching enzyme MyTH4 PF00784.17 ELR25679.1 - 7.2e-28 97.2 0.0 1.5e-27 96.2 0.0 1.6 1 0 0 1 1 1 1 MyTH4 domain SH3_1 PF00018.28 ELR25679.1 - 2.3e-11 43.1 0.0 4.4e-11 42.2 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 ELR25679.1 - 7.1e-09 35.4 0.0 1.4e-08 34.5 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 ELR25679.1 - 7.4e-09 35.2 0.0 1.6e-08 34.1 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain FERM_M PF00373.18 ELR25679.1 - 0.015 15.7 0.0 0.034 14.6 0.0 1.6 1 0 0 1 1 1 0 FERM central domain Myosin_head PF00063.21 ELR25680.1 - 1.7e-245 816.4 0.1 1.7e-245 816.4 0.1 1.5 2 0 0 2 2 1 1 Myosin head (motor domain) MyTH4 PF00784.17 ELR25680.1 - 9.1e-20 71.2 0.1 2e-18 66.8 0.1 3.1 1 1 0 1 1 1 1 MyTH4 domain FERM_M PF00373.18 ELR25680.1 - 6.6e-07 29.8 0.0 3.3e-05 24.3 0.0 3.0 3 1 0 3 3 2 1 FERM central domain FERM_N PF09379.10 ELR25680.1 - 2.3e-05 24.2 0.0 5.2e-05 23.1 0.0 1.6 1 0 0 1 1 1 1 FERM N-terminal domain IQ PF00612.27 ELR25680.1 - 6.2e-05 22.5 22.7 0.00042 19.8 0.1 4.7 4 0 0 4 4 4 2 IQ calmodulin-binding motif AAA_22 PF13401.6 ELR25680.1 - 0.031 14.5 0.0 0.15 12.3 0.0 2.2 1 0 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 ELR25680.1 - 0.061 13.2 0.2 0.27 11.1 0.0 2.1 2 0 0 2 2 2 0 RsgA GTPase AAA_16 PF13191.6 ELR25680.1 - 0.065 13.6 2.6 0.12 12.8 0.0 2.7 3 0 0 3 3 3 0 AAA ATPase domain ABC_tran PF00005.27 ELR25680.1 - 0.32 11.5 1.6 0.77 10.3 0.0 2.4 2 0 0 2 2 2 0 ABC transporter Borrelia_P83 PF05262.11 ELR25680.1 - 0.96 7.9 13.6 1.6 7.1 13.6 1.3 1 0 0 1 1 1 0 Borrelia P83/100 protein AAA_23 PF13476.6 ELR25680.1 - 2.5 8.5 13.9 4.5 7.7 0.1 2.8 2 0 0 2 2 2 0 AAA domain AAA_11 PF13086.6 ELR25680.1 - 4.4 7.0 13.9 50 3.6 0.0 3.0 3 0 0 3 3 3 0 AAA domain SIR2 PF02146.17 ELR25681.1 - 3.8e-22 79.1 0.1 8e-22 78.0 0.1 1.6 1 0 0 1 1 1 1 Sir2 family YEATS PF03366.16 ELR25681.1 - 5.9e-19 67.8 0.0 1.1e-18 67.0 0.0 1.5 1 0 0 1 1 1 1 YEATS family TPP_enzyme_M PF00205.22 ELR25681.1 - 0.0019 17.9 0.0 0.33 10.7 0.0 2.4 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, central domain ALMT PF11744.8 ELR25681.1 - 0.034 13.0 1.6 0.049 12.5 1.6 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Pox_P4B PF03292.14 ELR25681.1 - 0.1 10.8 0.6 0.15 10.3 0.6 1.1 1 0 0 1 1 1 0 Poxvirus P4B major core protein Zn-ribbon_8 PF09723.10 ELR25681.1 - 0.19 11.9 1.3 0.67 10.1 1.3 2.0 1 0 0 1 1 1 0 Zinc ribbon domain TFIIE-A_C PF11521.8 ELR25681.1 - 0.2 12.0 5.9 6.7 7.1 8.2 2.3 2 0 0 2 2 2 0 C-terminal general transcription factor TFIIE alpha Tmemb_161AB PF10268.9 ELR25681.1 - 0.51 8.9 0.9 0.74 8.4 0.9 1.1 1 0 0 1 1 1 0 Predicted transmembrane protein 161AB SART-1 PF03343.13 ELR25681.1 - 0.89 8.0 16.5 0.027 13.1 10.2 1.5 2 0 0 2 2 2 0 SART-1 family DUF3915 PF13054.6 ELR25681.1 - 1.8 8.6 4.7 0.6 10.1 0.3 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF3915) FancD2 PF14631.6 ELR25681.1 - 3 5.1 7.8 3.9 4.7 7.8 1.0 1 0 0 1 1 1 0 Fanconi anaemia protein FancD2 nuclease GOLD_2 PF13897.6 ELR25681.1 - 4.2 7.9 5.4 9.6 6.7 5.4 1.6 1 0 0 1 1 1 0 Golgi-dynamics membrane-trafficking Peptidase_S49_N PF08496.10 ELR25681.1 - 7.6 6.6 7.4 0.92 9.6 3.2 1.6 2 0 0 2 2 2 0 Peptidase family S49 N-terminal TFB6 PF17110.5 ELR25681.1 - 8.9 6.0 7.8 26 4.5 6.9 2.2 2 0 0 2 2 2 0 Subunit 11 of the general transcription factor TFIIH Arf PF00025.21 ELR25682.1 - 3.3e-70 235.1 0.2 3.6e-70 234.9 0.2 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 ELR25682.1 - 1.5e-15 57.4 0.1 2.2e-15 57.0 0.1 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 ELR25682.1 - 4e-14 52.5 0.1 4.4e-14 52.4 0.1 1.1 1 0 0 1 1 1 1 Ras family SRPRB PF09439.10 ELR25682.1 - 4.4e-13 49.1 0.1 5.5e-13 48.7 0.1 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.20 ELR25682.1 - 7.7e-13 48.3 1.8 1.4e-09 37.6 0.2 2.3 1 1 1 2 2 2 2 G-protein alpha subunit Gtr1_RagA PF04670.12 ELR25682.1 - 1.4e-10 40.9 0.0 1.7e-10 40.6 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 ELR25682.1 - 1.8e-06 28.0 0.0 2.6e-06 27.5 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_25 PF13481.6 ELR25682.1 - 0.035 13.7 0.2 0.052 13.1 0.2 1.3 1 1 0 1 1 1 0 AAA domain 6PF2K PF01591.18 ELR25682.1 - 0.048 13.0 0.1 0.12 11.6 0.0 1.5 1 1 0 1 1 1 0 6-phosphofructo-2-kinase ABC_tran PF00005.27 ELR25682.1 - 0.048 14.2 0.0 0.07 13.7 0.0 1.4 1 1 0 1 1 1 0 ABC transporter PAD_M PF08527.10 ELR25682.1 - 0.09 12.4 0.0 0.29 10.8 0.0 1.8 2 0 0 2 2 2 0 Protein-arginine deiminase (PAD) middle domain AAA_18 PF13238.6 ELR25682.1 - 0.13 12.8 0.2 0.24 11.9 0.2 1.7 1 1 0 1 1 1 0 AAA domain cobW PF02492.19 ELR25682.1 - 0.27 10.8 1.2 8.8 5.9 0.0 2.1 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain F_actin_bund_C PF18060.1 ELR25683.1 - 1e-16 60.8 15.5 1e-16 60.8 15.5 5.7 1 1 4 5 5 5 1 F actin bundling C terminal Lipase_GDSL_2 PF13472.6 ELR25684.1 - 6.8e-07 29.9 0.1 1.6e-06 28.6 0.1 1.6 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 ELR25684.1 - 3.6e-05 23.8 0.0 4.9e-05 23.4 0.0 1.2 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Mito_carr PF00153.27 ELR25685.1 - 6.2e-21 74.1 0.0 2.6e-19 68.9 0.0 2.0 2 0 0 2 2 2 2 Mitochondrial carrier protein Topoisom_I PF01028.20 ELR25686.1 - 1.6e-97 325.3 4.5 1.6e-97 325.3 4.5 2.3 3 0 0 3 3 3 1 Eukaryotic DNA topoisomerase I, catalytic core Topoisom_I_N PF02919.15 ELR25686.1 - 2.7e-93 311.4 5.5 2.7e-93 311.4 5.5 3.9 4 2 0 4 4 4 1 Eukaryotic DNA topoisomerase I, DNA binding fragment Topo_C_assoc PF14370.6 ELR25686.1 - 1e-19 70.2 0.3 4.4e-19 68.2 0.3 2.2 1 0 0 1 1 1 1 C-terminal topoisomerase domain Mem_trans PF03547.18 ELR25686.1 - 0.038 12.4 0.8 0.046 12.1 0.8 1.3 1 0 0 1 1 1 0 Membrane transport protein ANAPC16 PF17256.2 ELR25686.1 - 0.048 14.0 0.1 0.13 12.7 0.1 1.7 1 0 0 1 1 1 0 Anaphase-promoting complex, subunit 16 Macoilin PF09726.9 ELR25686.1 - 0.16 10.5 40.7 0.011 14.4 28.3 2.6 2 0 0 2 2 2 0 Macoilin family RasGAP PF00616.19 ELR25687.1 - 2.7e-28 99.1 0.2 2.8e-26 92.5 0.2 4.1 3 1 1 4 4 4 2 GTPase-activator protein for Ras-like GTPase START PF01852.19 ELR25687.1 - 5.3e-12 45.6 0.0 1.1e-11 44.6 0.0 1.4 1 0 0 1 1 1 1 START domain RGS PF00615.19 ELR25687.1 - 0.057 13.7 0.0 0.37 11.1 0.0 2.3 1 1 0 1 1 1 0 Regulator of G protein signaling domain TPR_12 PF13424.6 ELR25688.1 - 2.4e-107 351.4 48.2 6.9e-21 74.3 0.3 8.0 3 2 5 9 9 9 8 Tetratricopeptide repeat TPR_10 PF13374.6 ELR25688.1 - 3.3e-101 328.8 21.7 2.7e-10 39.8 0.0 11.8 11 0 0 11 11 11 11 Tetratricopeptide repeat TPR_1 PF00515.28 ELR25688.1 - 6.6e-45 149.2 36.0 4.3e-06 26.3 0.0 11.8 11 0 0 11 11 11 9 Tetratricopeptide repeat TPR_7 PF13176.6 ELR25688.1 - 7.3e-45 147.7 22.6 4.4e-06 26.3 0.0 11.7 11 0 0 11 11 11 9 Tetratricopeptide repeat TPR_8 PF13181.6 ELR25688.1 - 1.8e-31 105.6 33.2 4.4e-05 23.4 0.1 12.0 11 0 0 11 11 11 7 Tetratricopeptide repeat TPR_2 PF07719.17 ELR25688.1 - 1.6e-30 102.8 45.8 0.00044 20.2 0.1 12.0 12 0 0 12 12 11 10 Tetratricopeptide repeat TPR_16 PF13432.6 ELR25688.1 - 5.8e-17 62.1 25.3 0.0049 17.5 1.3 8.8 6 3 0 6 6 6 5 Tetratricopeptide repeat DUF4062 PF13271.6 ELR25688.1 - 1.5e-16 60.5 0.0 4.3e-16 59.1 0.0 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF4062) TPR_MalT PF17874.1 ELR25688.1 - 4.4e-16 59.2 6.9 9.2e-07 28.5 1.1 4.3 1 1 3 4 4 4 4 MalT-like TPR region TPR_19 PF14559.6 ELR25688.1 - 3.2e-15 56.4 17.6 0.00033 21.1 0.1 7.8 6 2 1 7 7 7 4 Tetratricopeptide repeat TPR_14 PF13428.6 ELR25688.1 - 1.5e-12 47.2 29.3 1.8 9.6 0.0 12.2 10 2 2 12 12 11 2 Tetratricopeptide repeat TPR_17 PF13431.6 ELR25688.1 - 1.8e-11 43.6 12.7 0.042 14.2 0.0 10.4 10 0 0 10 10 10 1 Tetratricopeptide repeat NACHT PF05729.12 ELR25688.1 - 4e-10 39.9 0.0 7.6e-10 38.9 0.0 1.5 1 0 0 1 1 1 1 NACHT domain SHNi-TPR PF10516.9 ELR25688.1 - 3.3e-05 23.2 0.3 3.1 7.3 0.1 5.7 7 0 0 7 7 6 1 SHNi-TPR AAA_16 PF13191.6 ELR25688.1 - 4.4e-05 23.9 0.0 0.00045 20.7 0.0 2.8 2 0 0 2 2 1 1 AAA ATPase domain DUF2225 PF09986.9 ELR25688.1 - 8.1e-05 22.4 3.4 0.0035 17.1 0.0 3.4 2 1 1 3 3 3 1 Uncharacterized protein conserved in bacteria (DUF2225) AAA_22 PF13401.6 ELR25688.1 - 8.2e-05 22.9 0.0 0.00025 21.4 0.0 1.8 1 0 0 1 1 1 1 AAA domain RPN6_N PF18055.1 ELR25688.1 - 0.0024 18.2 0.2 2.1 8.7 0.0 4.1 4 0 0 4 4 3 1 26S proteasome regulatory subunit RPN6 N-terminal domain MIT PF04212.18 ELR25688.1 - 0.003 17.6 12.4 47 4.1 0.0 7.9 8 1 1 9 9 8 0 MIT (microtubule interacting and transport) domain ANAPC3 PF12895.7 ELR25688.1 - 0.0034 17.6 15.3 0.41 10.9 0.1 6.4 2 1 5 7 7 6 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_9 PF13371.6 ELR25688.1 - 0.0042 17.2 9.9 0.024 14.8 0.2 5.5 4 2 2 6 6 6 1 Tetratricopeptide repeat TPR_11 PF13414.6 ELR25688.1 - 0.0047 16.6 24.0 3 7.6 0.0 8.8 8 1 1 9 9 8 2 TPR repeat RPN7 PF10602.9 ELR25688.1 - 0.018 14.7 2.2 5.9 6.6 0.0 5.0 4 1 1 5 5 5 0 26S proteasome subunit RPN7 TPR_5 PF12688.7 ELR25688.1 - 0.019 15.2 6.6 39 4.5 0.0 6.5 5 1 0 5 5 4 0 Tetratrico peptide repeat MAGE PF01454.19 ELR25688.1 - 0.024 14.4 0.0 0.069 12.9 0.0 1.7 2 0 0 2 2 1 0 MAGE family TPR_4 PF07721.14 ELR25688.1 - 0.037 14.6 14.8 37 5.4 0.0 8.7 9 0 0 9 9 8 0 Tetratricopeptide repeat AAA_29 PF13555.6 ELR25688.1 - 0.064 13.0 0.0 0.15 11.8 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain PhoH PF02562.16 ELR25688.1 - 0.17 11.3 0.0 0.37 10.2 0.0 1.5 1 0 0 1 1 1 0 PhoH-like protein PPR PF01535.20 ELR25688.1 - 0.19 12.0 0.4 73 3.9 0.0 4.7 5 0 0 5 5 4 0 PPR repeat TPR_6 PF13174.6 ELR25688.1 - 0.36 11.6 28.4 12 6.8 0.0 9.4 9 0 0 9 9 8 0 Tetratricopeptide repeat TPR_3 PF07720.12 ELR25688.1 - 5.1 7.2 20.9 6.2 6.9 0.1 6.8 8 0 0 8 8 6 0 Tetratricopeptide repeat RFX_DNA_binding PF02257.15 ELR25689.1 - 5.3e-17 62.2 0.1 1.2e-16 61.1 0.0 1.6 2 0 0 2 2 2 1 RFX DNA-binding domain Pox_D5 PF03288.16 ELR25689.1 - 0.0021 18.5 0.0 0.0041 17.6 0.0 1.4 1 0 0 1 1 1 1 Poxvirus D5 protein-like RFX_DNA_binding PF02257.15 ELR25690.1 - 3.3e-17 62.9 1.2 8.4e-17 61.6 0.1 2.2 2 0 0 2 2 2 1 RFX DNA-binding domain Pox_D5 PF03288.16 ELR25690.1 - 0.0044 17.5 0.1 0.0086 16.5 0.1 1.4 1 0 0 1 1 1 1 Poxvirus D5 protein-like ThiF PF00899.21 ELR25692.1 - 8.1e-47 159.6 0.0 1.2e-46 159.1 0.0 1.1 1 0 0 1 1 1 1 ThiF family UDPG_MGDP_dh_N PF03721.14 ELR25692.1 - 0.0052 16.4 0.0 0.0099 15.5 0.0 1.5 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain SlyX PF04102.12 ELR25692.1 - 0.054 14.1 2.3 0.19 12.4 2.3 2.0 1 0 0 1 1 1 0 SlyX Csm1_N PF18504.1 ELR25692.1 - 0.055 13.8 1.6 0.055 13.8 1.6 2.0 2 0 0 2 2 2 0 Csm1 N-terminal domain PglD_N PF17836.1 ELR25692.1 - 0.084 13.5 0.1 0.86 10.3 0.0 2.4 2 0 0 2 2 2 0 PglD N-terminal domain FAD_binding_3 PF01494.19 ELR25692.1 - 0.086 12.1 0.2 0.16 11.2 0.2 1.4 1 0 0 1 1 1 0 FAD binding domain TrkA_N PF02254.18 ELR25692.1 - 0.088 13.1 2.3 0.091 13.0 0.0 2.3 3 0 0 3 3 3 0 TrkA-N domain DUF2680 PF10925.8 ELR25692.1 - 0.17 11.9 2.7 0.43 10.6 2.7 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2680) Seryl_tRNA_N PF02403.22 ELR25692.1 - 2.9 8.2 9.3 3.7 7.8 1.4 2.6 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain DUF3990 PF13151.6 ELR25694.1 - 9.5e-17 61.1 0.0 1.4e-16 60.5 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3990) ART-PolyVal PF18760.1 ELR25694.1 - 0.014 16.4 0.2 0.024 15.7 0.2 1.3 1 0 0 1 1 1 0 ADP-Ribosyltransferase in polyvalent proteins RHD_DNA_bind PF00554.22 ELR25697.1 - 0.031 14.2 0.4 0.036 14.0 0.4 1.0 1 0 0 1 1 1 0 Rel homology DNA-binding domain Ustilago_mating PF05722.12 ELR25697.1 - 0.14 11.7 0.0 0.15 11.6 0.0 1.0 1 0 0 1 1 1 0 Ustilago B locus mating-type protein DUF3990 PF13151.6 ELR25698.1 - 1.3e-08 34.6 0.0 2.1e-08 34.0 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3990) CNTF PF01110.17 ELR25698.1 - 0.15 11.4 0.0 0.25 10.7 0.0 1.3 1 0 0 1 1 1 0 Ciliary neurotrophic factor PEPCK_ATP PF01293.20 ELR25700.1 - 3.6e-29 101.8 0.0 4.7e-29 101.4 0.0 1.1 1 0 0 1 1 1 1 Phosphoenolpyruvate carboxykinase NUDIX PF00293.28 ELR25700.1 - 6.1e-15 55.4 0.0 1.4e-14 54.2 0.0 1.7 1 0 0 1 1 1 1 NUDIX domain SH3_16 PF18348.1 ELR25700.1 - 0.024 14.4 0.2 0.052 13.4 0.2 1.5 1 0 0 1 1 1 0 Bacterial dipeptidyl-peptidase Sh3 domain FHA PF00498.26 ELR25701.1 - 2.1e-09 37.6 0.1 5.9e-08 33.0 0.0 2.5 2 0 0 2 2 2 1 FHA domain Cbl_N2 PF02761.14 ELR25701.1 - 2.2e-06 28.3 0.3 5.5e-06 27.0 0.3 1.7 1 0 0 1 1 1 1 CBL proto-oncogene N-terminus, EF hand-like domain Spt20 PF12090.8 ELR25701.1 - 0.048 13.3 2.7 0.09 12.4 2.2 1.7 2 0 0 2 2 2 0 Spt20 family DUF908 PF06012.12 ELR25701.1 - 0.11 11.9 1.9 0.62 9.4 0.0 2.2 2 0 0 2 2 2 0 Domain of Unknown Function (DUF908) EF-hand_6 PF13405.6 ELR25701.1 - 0.15 12.1 0.2 3.8 7.7 0.1 2.7 2 0 0 2 2 2 0 EF-hand domain DUF5308 PF17233.2 ELR25701.1 - 1.1 9.5 5.0 4.8 7.4 0.1 2.5 3 0 0 3 3 3 0 Family of unknown function (DUF5308) RAG1_imp_bd PF12560.8 ELR25701.1 - 6.4 6.2 7.5 0.88 9.1 0.1 2.1 2 0 0 2 2 2 0 RAG1 importin binding DUF2052 PF09747.9 ELR25702.1 - 0.68 10.0 21.0 0.16 12.0 17.5 1.6 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) Presenilin PF01080.17 ELR25702.1 - 0.91 8.2 13.4 1.2 7.8 13.4 1.1 1 0 0 1 1 1 0 Presenilin DUF4407 PF14362.6 ELR25702.1 - 1.3 8.3 27.9 1.9 7.8 27.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF1682 PF07946.14 ELR25702.1 - 1.7 7.7 20.4 2.9 7.0 20.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) Hid1 PF12722.7 ELR25702.1 - 1.8 6.6 9.2 2.2 6.3 9.2 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein V_ATPase_I PF01496.19 ELR25702.1 - 2.2 6.1 8.7 2.3 6.0 8.7 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family SAPS PF04499.15 ELR25702.1 - 2.2 7.0 9.1 2.6 6.7 9.1 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Neur_chan_memb PF02932.16 ELR25702.1 - 2.6 8.1 4.7 2.8 7.9 4.7 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Spore_coat_CotO PF14153.6 ELR25702.1 - 2.8 7.8 17.3 5 7.0 17.3 1.5 1 0 0 1 1 1 0 Spore coat protein CotO SLC12 PF03522.15 ELR25702.1 - 3.1 6.7 9.3 4.3 6.2 9.3 1.1 1 0 0 1 1 1 0 Solute carrier family 12 FUSC PF04632.12 ELR25702.1 - 4.9 5.5 17.0 5.5 5.4 17.0 1.2 1 0 0 1 1 1 0 Fusaric acid resistance protein family TP53IP5 PF15331.6 ELR25702.1 - 6 6.9 10.3 11 6.1 10.3 1.4 1 0 0 1 1 1 0 Cellular tumour antigen p53-inducible 5 VPS13_C PF16909.5 ELR25704.1 - 3.5e-11 43.2 1.3 5.6e-09 36.0 0.0 2.8 2 0 0 2 2 2 2 Vacuolar-sorting-associated 13 protein C-terminal ATG_C PF09333.11 ELR25704.1 - 1.5e-05 25.2 0.0 4.4e-05 23.7 0.0 1.7 1 0 0 1 1 1 1 Autophagy-related protein C terminal domain SHR-BD PF06650.12 ELR25704.1 - 0.0009 18.7 0.1 17 4.7 0.0 4.0 4 0 0 4 4 4 2 SHR-binding domain of vacuolar-sorting associated protein 13 Dsh_C PF12316.8 ELR25705.1 - 0.01 16.2 0.2 0.01 16.2 0.2 2.1 2 1 0 2 2 2 0 Segment polarity protein dishevelled (Dsh) C terminal FAA_hydrolase PF01557.18 ELR25707.1 - 1.1e-56 192.0 0.0 1.5e-56 191.5 0.0 1.2 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family FAA_hydrolase_N PF09298.11 ELR25707.1 - 3.9e-33 113.8 0.0 6.8e-33 113.1 0.0 1.4 1 0 0 1 1 1 1 Fumarylacetoacetase N-terminal LRR_8 PF13855.6 ELR25708.1 - 5.8e-18 64.4 15.0 1.1e-08 34.6 3.9 3.5 1 1 2 3 3 3 3 Leucine rich repeat LRR_4 PF12799.7 ELR25708.1 - 2e-14 53.4 12.1 8.7e-06 26.0 0.2 4.4 2 2 3 5 5 5 3 Leucine Rich repeats (2 copies) zf-RanBP PF00641.18 ELR25708.1 - 0.00012 21.4 1.0 0.00027 20.2 1.0 1.5 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others LRR_1 PF00560.33 ELR25708.1 - 0.00021 21.4 11.0 2.7 8.9 0.0 6.6 7 0 0 7 7 7 1 Leucine Rich Repeat LRR_6 PF13516.6 ELR25708.1 - 0.2 11.8 7.2 11 6.4 0.0 5.2 5 0 0 5 5 5 0 Leucine Rich repeat DZR PF12773.7 ELR25708.1 - 0.28 11.3 1.5 1 9.5 0.3 2.1 2 0 0 2 2 2 0 Double zinc ribbon DDRGK PF09756.9 ELR25708.1 - 1.3 8.6 17.8 3 7.4 17.8 1.6 1 0 0 1 1 1 0 DDRGK domain Presenilin PF01080.17 ELR25708.1 - 2.7 6.7 5.5 4.3 6.0 5.5 1.2 1 0 0 1 1 1 0 Presenilin CDC45 PF02724.14 ELR25708.1 - 4.1 5.6 11.4 6.5 4.9 11.4 1.2 1 0 0 1 1 1 0 CDC45-like protein PITH PF06201.13 ELR25709.1 - 5e-32 111.2 0.1 8.7e-32 110.4 0.1 1.4 1 0 0 1 1 1 1 PITH domain XRN_M PF17846.1 ELR25709.1 - 3.6e-10 39.4 12.0 1.6e-07 30.7 0.5 3.1 3 1 0 3 3 3 2 Xrn1 helical domain CENP-B_dimeris PF09026.10 ELR25709.1 - 0.38 11.2 6.7 6.2 7.3 1.3 2.5 2 0 0 2 2 2 0 Centromere protein B dimerisation domain Utp21 PF04192.12 ELR25709.1 - 0.43 10.1 6.7 0.13 11.7 1.6 2.4 2 1 0 2 2 2 0 Utp21 specific WD40 associated putative domain M_domain PF12938.7 ELR25712.1 - 0.059 13.2 0.0 0.059 13.2 0.0 1.8 2 0 0 2 2 2 0 M domain of GW182 RNF220 PF15926.5 ELR25712.1 - 0.65 9.6 3.7 0.14 11.8 0.5 1.4 2 0 0 2 2 2 0 E3 ubiquitin-protein ligase RNF220 GSH-S_N PF02951.14 ELR25713.1 - 0.0073 16.4 0.1 0.017 15.2 0.1 1.5 1 1 1 2 2 2 1 Prokaryotic glutathione synthetase, N-terminal domain CdiI_3 PF18616.1 ELR25713.1 - 0.095 12.6 0.2 0.24 11.3 0.0 1.7 2 0 0 2 2 2 0 CDI immunity proteins Adeno_E3 PF06040.11 ELR25715.1 - 0.008 16.3 0.0 0.014 15.6 0.0 1.3 1 0 0 1 1 1 1 Adenovirus E3 protein DUF3040 PF11239.8 ELR25715.1 - 0.065 13.5 0.9 0.1 12.8 0.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3040) Myosin_head PF00063.21 ELR25716.1 - 1e-268 893.2 0.0 2.1e-268 892.1 0.0 1.6 1 0 0 1 1 1 1 Myosin head (motor domain) Myosin_tail_1 PF01576.19 ELR25716.1 - 2e-16 59.1 161.1 1.6e-08 32.9 81.9 3.3 1 1 2 3 3 3 3 Myosin tail Tropomyosin PF00261.20 ELR25716.1 - 7.7e-05 22.2 52.3 7.7e-05 22.2 52.3 5.4 2 1 2 4 4 3 1 Tropomyosin DUF1664 PF07889.12 ELR25716.1 - 0.0012 18.8 0.8 0.0012 18.8 0.8 8.0 3 1 5 8 8 8 2 Protein of unknown function (DUF1664) Myosin_N PF02736.19 ELR25716.1 - 0.0021 17.9 0.3 0.0047 16.7 0.3 1.7 1 0 0 1 1 1 1 Myosin N-terminal SH3-like domain Filament PF00038.21 ELR25716.1 - 0.0056 16.3 147.1 0.081 12.5 13.7 7.4 2 2 3 5 5 5 3 Intermediate filament protein IQ PF00612.27 ELR25716.1 - 0.01 15.6 2.0 2.3 8.3 0.3 2.7 2 0 0 2 2 2 0 IQ calmodulin-binding motif AAA_19 PF13245.6 ELR25716.1 - 0.052 13.9 0.6 0.31 11.3 0.0 2.7 2 0 0 2 2 2 0 AAA domain NTPase_1 PF03266.15 ELR25716.1 - 0.21 11.5 5.6 1 9.2 0.1 3.1 3 0 0 3 3 3 0 NTPase AAA_22 PF13401.6 ELR25716.1 - 0.29 11.4 0.0 0.29 11.4 0.0 3.4 3 0 0 3 3 3 0 AAA domain GAS PF13851.6 ELR25716.1 - 0.64 9.3 149.7 0.015 14.6 25.2 8.0 1 1 6 8 8 8 0 Growth-arrest specific micro-tubule binding APG6_N PF17675.1 ELR25716.1 - 5.4 7.6 179.6 0.69 10.4 34.6 8.7 1 1 9 10 10 9 0 Apg6 coiled-coil region Homeodomain PF00046.29 ELR25717.1 - 1.1e-16 60.4 0.4 2.3e-16 59.4 0.4 1.5 1 0 0 1 1 1 1 Homeodomain KIX_2 PF16987.5 ELR25717.1 - 0.041 13.9 0.0 0.11 12.5 0.0 1.6 1 0 0 1 1 1 0 KIX domain Homeobox_KN PF05920.11 ELR25717.1 - 0.09 12.7 0.1 0.09 12.7 0.1 2.1 2 0 0 2 2 2 0 Homeobox KN domain Dicty_REP PF05086.12 ELR25717.1 - 0.18 9.7 5.9 0.27 9.2 5.9 1.2 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Mucin PF01456.17 ELR25717.1 - 5 7.1 13.1 16 5.5 13.1 1.8 1 0 0 1 1 1 0 Mucin-like glycoprotein SH3_1 PF00018.28 ELR25719.1 - 4.5e-24 83.8 0.8 6.6e-16 57.7 0.1 2.5 2 0 0 2 2 2 2 SH3 domain SH3_9 PF14604.6 ELR25719.1 - 4.6e-22 77.6 5.2 7e-12 45.0 0.1 2.9 3 0 0 3 3 3 2 Variant SH3 domain SH3_2 PF07653.17 ELR25719.1 - 7.1e-22 76.9 0.5 2.5e-16 59.1 0.1 2.4 2 0 0 2 2 2 2 Variant SH3 domain FCH PF00611.23 ELR25719.1 - 8.2e-15 54.9 3.1 8.2e-15 54.9 3.1 2.1 2 0 0 2 2 2 1 Fes/CIP4, and EFC/F-BAR homology domain MazE_antitoxin PF04014.18 ELR25719.1 - 0.67 9.9 2.6 5.1 7.1 0.2 2.8 3 0 0 3 3 3 0 Antidote-toxin recognition MazE, bacterial antitoxin Pkinase PF00069.25 ELR25720.1 - 1.2e-31 110.0 0.7 1.5e-31 109.7 0.7 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ELR25720.1 - 1.2e-15 57.5 0.3 1.5e-15 57.2 0.3 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase FTA2 PF13095.6 ELR25720.1 - 7.6e-05 22.4 0.3 0.082 12.5 0.0 2.3 1 1 1 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 Kdo PF06293.14 ELR25720.1 - 0.012 14.9 0.4 0.022 14.1 0.4 1.4 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 ELR25720.1 - 0.16 11.8 0.0 0.21 11.5 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family OB_NTP_bind PF07717.16 ELR25721.1 - 3.1e-20 72.3 0.0 6.4e-20 71.3 0.0 1.6 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold HA2 PF04408.23 ELR25721.1 - 1.6e-16 60.5 0.1 1.6e-16 60.5 0.1 2.8 3 0 0 3 3 3 1 Helicase associated domain (HA2) Helicase_C PF00271.31 ELR25721.1 - 5.8e-14 52.4 0.1 2.3e-13 50.5 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain RWD PF05773.22 ELR25721.1 - 1.5e-09 38.1 0.0 8.1e-09 35.8 0.0 2.2 2 0 0 2 2 2 1 RWD domain DEAD PF00270.29 ELR25721.1 - 1.4e-08 34.7 0.1 4.5e-08 33.0 0.1 1.9 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 ELR25721.1 - 0.00013 22.3 0.4 0.00067 19.9 0.4 2.3 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.6 ELR25721.1 - 0.0028 18.0 0.0 0.0075 16.6 0.0 1.8 1 0 0 1 1 1 1 AAA domain DND1_DSRM PF14709.7 ELR25721.1 - 0.0045 17.2 0.1 0.014 15.7 0.1 1.9 1 0 0 1 1 1 1 double strand RNA binding domain from DEAD END PROTEIN 1 T2SSE PF00437.20 ELR25721.1 - 0.0049 16.0 0.0 0.01 14.9 0.0 1.5 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_14 PF13173.6 ELR25721.1 - 0.056 13.5 0.0 0.46 10.5 0.0 2.3 2 0 0 2 2 2 0 AAA domain ATPase PF06745.13 ELR25721.1 - 0.057 12.8 0.4 0.26 10.6 0.0 2.2 2 0 0 2 2 2 0 KaiC RsgA_GTPase PF03193.16 ELR25721.1 - 0.059 13.3 0.0 0.22 11.4 0.0 2.0 1 0 0 1 1 1 0 RsgA GTPase AAA_23 PF13476.6 ELR25721.1 - 0.085 13.3 5.3 4.7 7.7 0.0 3.1 3 0 0 3 3 2 0 AAA domain MqsR_toxin PF15723.5 ELR25721.1 - 0.17 12.3 0.0 0.49 10.8 0.0 1.8 1 0 0 1 1 1 0 Motility quorum-sensing regulator, toxin of MqsA RRM_1 PF00076.22 ELR25722.1 - 8.2e-19 67.2 0.0 3.1e-09 36.5 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Ribosomal_L18 PF17135.4 ELR25723.1 - 3.2e-87 290.8 3.5 3.5e-87 290.6 3.5 1.0 1 0 0 1 1 1 1 Ribosomal protein 60S L18 and 50S L18e Ribosomal_L27A PF00828.19 ELR25723.1 - 0.0068 17.1 0.0 0.018 15.7 0.0 1.8 1 1 0 1 1 1 1 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A GHMP_kinases_N PF00288.26 ELR25725.1 - 2.5e-18 66.1 1.1 2.5e-18 66.1 1.1 2.7 3 0 0 3 3 3 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.13 ELR25725.1 - 2.1e-06 28.0 0.1 9.8e-06 25.9 0.0 2.1 1 1 1 2 2 2 1 GHMP kinases C terminal Pkinase_Tyr PF07714.17 ELR25726.1 - 3e-63 213.5 0.0 3.6e-63 213.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ELR25726.1 - 8.6e-40 136.8 0.0 1.1e-39 136.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain SAM_1 PF00536.30 ELR25726.1 - 2.2e-05 24.8 0.2 4.3e-05 23.9 0.2 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 ELR25726.1 - 0.00069 19.7 0.3 0.0013 18.8 0.3 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Kinase-like PF14531.6 ELR25726.1 - 0.011 15.0 0.1 0.023 14.0 0.1 1.4 1 1 0 1 1 1 0 Kinase-like Pullulanase_N2 PF17967.1 ELR25726.1 - 0.17 12.8 0.2 5.4 7.9 0.0 2.3 2 0 0 2 2 2 0 Pullulanase N2 domain Lipase_3 PF01764.25 ELR25727.1 - 2.3e-15 56.7 0.0 4.4e-15 55.8 0.0 1.4 1 0 0 1 1 1 1 Lipase (class 3) Abhydrolase_6 PF12697.7 ELR25727.1 - 3.5e-06 27.8 1.3 1.5e-05 25.7 0.1 2.4 3 0 0 3 3 3 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 ELR25727.1 - 0.0069 15.7 0.0 0.015 14.6 0.0 1.5 1 0 0 1 1 1 1 Serine aminopeptidase, S33 LIDHydrolase PF10230.9 ELR25727.1 - 0.0072 15.9 0.0 0.014 15.0 0.0 1.4 1 0 0 1 1 1 1 Lipid-droplet associated hydrolase Abhydrolase_3 PF07859.13 ELR25727.1 - 0.041 13.7 0.3 0.15 11.9 0.0 1.9 2 0 0 2 2 2 0 alpha/beta hydrolase fold PIN_5 PF08745.11 ELR25727.1 - 0.13 11.7 0.1 0.23 10.9 0.1 1.3 1 0 0 1 1 1 0 PINc domain ribonuclease Ank_2 PF12796.7 ELR25728.1 - 5.2e-77 254.5 14.9 8.4e-17 61.5 0.1 5.0 1 1 7 8 8 8 8 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ELR25728.1 - 1.6e-47 159.3 0.3 1.8e-08 34.8 0.0 8.5 3 2 5 8 8 8 8 Ankyrin repeats (many copies) Ank_5 PF13857.6 ELR25728.1 - 1.2e-43 146.5 9.6 5e-09 36.2 0.0 8.6 4 2 5 9 9 9 8 Ankyrin repeats (many copies) Ank PF00023.30 ELR25728.1 - 2.8e-43 144.5 10.9 6.8e-06 26.3 0.2 9.4 9 0 0 9 9 9 9 Ankyrin repeat Ank_3 PF13606.6 ELR25728.1 - 2.4e-42 138.1 3.3 0.00098 19.4 0.0 10.3 10 0 0 10 10 10 9 Ankyrin repeat FYVE PF01363.21 ELR25728.1 - 5.1e-06 26.5 2.5 0.00073 19.6 2.5 2.6 1 1 0 1 1 1 1 FYVE zinc finger LRR_4 PF12799.7 ELR25729.1 - 0.057 13.9 11.0 1.5 9.3 0.0 5.8 4 3 3 7 7 7 0 Leucine Rich repeats (2 copies) WD40 PF00400.32 ELR25730.1 - 3.1e-44 148.1 15.5 2.7e-06 28.0 0.0 7.4 7 0 0 7 7 7 7 WD domain, G-beta repeat Nup160 PF11715.8 ELR25730.1 - 4.3e-10 38.9 10.5 0.013 14.2 0.1 5.0 2 1 2 5 5 5 4 Nucleoporin Nup120/160 F-box-like PF12937.7 ELR25730.1 - 5.3e-08 32.6 0.9 1.5e-07 31.2 0.9 1.8 1 0 0 1 1 1 1 F-box-like ANAPC4_WD40 PF12894.7 ELR25730.1 - 9.7e-08 32.2 4.2 0.071 13.4 0.2 4.6 1 1 3 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ELR25730.1 - 0.00021 20.7 1.8 5.1 6.3 0.0 3.8 1 1 1 3 3 3 3 WD40-like domain F-box PF00646.33 ELR25730.1 - 0.0011 18.8 0.6 0.0028 17.5 0.6 1.6 1 0 0 1 1 1 1 F-box domain F-box_4 PF15966.5 ELR25730.1 - 0.0056 16.6 1.7 0.0094 15.8 0.6 2.1 2 0 0 2 2 2 1 F-box Nucleoporin_N PF08801.11 ELR25730.1 - 0.041 12.6 2.1 3.5 6.3 0.2 3.6 2 1 1 3 3 3 0 Nup133 N terminal like Dynein_C PF18199.1 ELR25730.1 - 0.096 11.9 1.9 0.14 11.3 1.9 1.2 1 0 0 1 1 1 0 Dynein heavy chain C-terminal domain zf-primase PF09329.11 ELR25730.1 - 8.9 6.2 6.8 11 5.9 0.4 2.9 3 0 0 3 3 3 0 Primase zinc finger SR-25 PF10500.9 ELR25731.1 - 1.3e-07 31.4 78.1 1.5e-07 31.3 5.6 5.1 5 0 0 5 5 5 3 Nuclear RNA-splicing-associated protein rRNA_processing PF08524.11 ELR25731.1 - 1.7 8.7 34.7 0.8 9.7 0.6 4.4 4 0 0 4 4 4 0 rRNA processing Rap_GAP PF02145.15 ELR25732.1 - 1.5e-46 158.3 0.7 2.7e-46 157.5 0.0 1.8 2 0 0 2 2 2 1 Rap/ran-GAP RasGAP PF00616.19 ELR25732.1 - 2.9 7.6 4.6 0.42 10.3 0.0 1.9 2 0 0 2 2 2 0 GTPase-activator protein for Ras-like GTPase HA PF03457.14 ELR25733.1 - 5.3e-16 58.7 2.4 1.3e-15 57.4 2.4 1.7 1 0 0 1 1 1 1 Helicase associated domain CDC50 PF03381.15 ELR25734.1 - 2e-90 303.1 1.5 2.4e-90 302.9 0.3 1.7 1 1 0 1 1 1 1 LEM3 (ligand-effect modulator 3) family / CDC50 family DUF2157 PF09925.9 ELR25734.1 - 0.1 12.4 0.8 15 5.3 0.8 2.3 2 0 0 2 2 2 0 Predicted membrane protein (DUF2157) SRP68 PF16969.5 ELR25735.1 - 1.2e-139 466.9 7.9 1.4e-139 466.7 7.9 1.0 1 0 0 1 1 1 1 RNA-binding signal recognition particle 68 BRO1 PF03097.18 ELR25735.1 - 2.1e-05 23.5 0.2 5.4e-05 22.2 0.2 1.7 1 0 0 1 1 1 1 BRO1-like domain TPR_6 PF13174.6 ELR25735.1 - 0.015 15.9 0.1 3.7 8.4 0.0 3.6 2 0 0 2 2 2 0 Tetratricopeptide repeat RE_ScaI PF09569.10 ELR25735.1 - 0.017 14.8 0.1 0.033 13.9 0.1 1.4 1 0 0 1 1 1 0 ScaI restriction endonuclease Peptidase_M60 PF13402.6 ELR25735.1 - 0.071 12.6 0.0 0.17 11.4 0.0 1.7 1 0 0 1 1 1 0 Peptidase M60, enhancin and enhancin-like TPR_2 PF07719.17 ELR25735.1 - 0.28 11.4 2.1 5.6 7.3 0.0 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat PAXIP1_C PF15364.6 ELR25735.1 - 1 9.7 6.1 14 6.0 0.1 3.9 4 0 0 4 4 4 0 PAXIP1-associated-protein-1 C term PTIP binding protein TPR_12 PF13424.6 ELR25735.1 - 1.2 9.4 8.1 0.56 10.5 0.7 3.5 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_16 PF13432.6 ELR25735.1 - 2 9.1 6.0 23 5.7 0.0 3.3 3 1 0 3 3 3 0 Tetratricopeptide repeat AAA PF00004.29 ELR25736.1 - 9e-36 123.2 0.0 2.5e-35 121.8 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 ELR25736.1 - 8.9e-11 41.4 0.0 2.4e-10 40.0 0.0 1.8 1 0 0 1 1 1 1 AAA+ lid domain AAA_16 PF13191.6 ELR25736.1 - 5.8e-05 23.5 0.1 0.021 15.2 0.0 3.7 4 0 0 4 4 4 1 AAA ATPase domain AAA_5 PF07728.14 ELR25736.1 - 0.00024 21.1 0.2 0.0035 17.4 0.2 2.5 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) RuvB_N PF05496.12 ELR25736.1 - 0.00044 20.0 0.0 0.0015 18.3 0.0 1.8 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_14 PF13173.6 ELR25736.1 - 0.00044 20.3 0.0 0.0012 18.9 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 ELR25736.1 - 0.001 19.6 0.0 0.0023 18.5 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_24 PF13479.6 ELR25736.1 - 0.0019 18.0 0.0 0.004 16.9 0.0 1.5 1 0 0 1 1 1 1 AAA domain Mg_chelatase PF01078.21 ELR25736.1 - 0.0025 17.3 0.7 0.0064 15.9 0.3 1.8 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI Sigma54_activat PF00158.26 ELR25736.1 - 0.0035 17.1 0.1 0.013 15.2 0.0 1.9 2 0 0 2 2 2 1 Sigma-54 interaction domain IstB_IS21 PF01695.17 ELR25736.1 - 0.0043 16.8 0.0 0.0099 15.6 0.0 1.6 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_2 PF07724.14 ELR25736.1 - 0.0044 17.1 0.0 0.019 15.1 0.0 2.1 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) TIP49 PF06068.13 ELR25736.1 - 0.0055 15.9 0.0 0.0089 15.3 0.0 1.2 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_22 PF13401.6 ELR25736.1 - 0.0066 16.7 0.1 0.038 14.2 0.1 2.2 1 1 1 2 2 2 1 AAA domain Hydin_ADK PF17213.3 ELR25736.1 - 0.0071 16.6 3.0 1.8 8.8 0.1 2.4 2 0 0 2 2 2 2 Hydin Adenylate kinase-like domain Parvo_NS1 PF01057.17 ELR25736.1 - 0.0073 15.4 0.0 0.014 14.5 0.0 1.4 1 0 0 1 1 1 1 Parvovirus non-structural protein NS1 AAA_7 PF12775.7 ELR25736.1 - 0.014 15.0 0.0 0.027 14.0 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region RNA_helicase PF00910.22 ELR25736.1 - 0.014 15.8 0.0 0.043 14.2 0.0 1.9 1 0 0 1 1 1 0 RNA helicase AAA_28 PF13521.6 ELR25736.1 - 0.023 15.0 0.3 0.44 10.8 0.0 2.4 2 0 0 2 2 2 0 AAA domain DUF815 PF05673.13 ELR25736.1 - 0.032 13.4 0.0 0.075 12.2 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_33 PF13671.6 ELR25736.1 - 0.039 14.1 0.0 0.095 12.9 0.0 1.7 1 0 0 1 1 1 0 AAA domain AFG1_ATPase PF03969.16 ELR25736.1 - 0.077 11.9 0.0 0.14 11.0 0.0 1.3 1 0 0 1 1 1 0 AFG1-like ATPase AAA_25 PF13481.6 ELR25736.1 - 0.097 12.2 0.1 0.42 10.2 0.0 2.0 2 0 0 2 2 2 0 AAA domain Rad17 PF03215.15 ELR25736.1 - 0.11 12.3 0.0 0.32 10.9 0.0 1.7 1 1 0 1 1 1 0 Rad17 P-loop domain TsaE PF02367.17 ELR25736.1 - 0.12 12.4 0.0 0.22 11.5 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_3 PF07726.11 ELR25736.1 - 0.14 12.0 0.0 0.28 11.0 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_30 PF13604.6 ELR25736.1 - 0.14 11.8 0.9 0.76 9.5 0.1 2.3 2 0 0 2 2 2 0 AAA domain ATPase PF06745.13 ELR25736.1 - 0.17 11.2 0.0 0.47 9.7 0.0 1.8 1 0 0 1 1 1 0 KaiC NACHT PF05729.12 ELR25736.1 - 0.17 11.8 0.3 0.44 10.5 0.3 1.7 1 0 0 1 1 1 0 NACHT domain Glyco_transf_49 PF13896.6 ELR25737.1 - 8.2e-54 183.2 3.4 8.7e-51 173.2 3.4 2.2 1 1 0 1 1 1 1 Glycosyl-transferase for dystroglycan fn3 PF00041.21 ELR25737.1 - 2.2e-08 34.4 0.3 1.7e-07 31.5 0.1 2.2 2 0 0 2 2 2 1 Fibronectin type III domain Pur_ac_phosph_N PF16656.5 ELR25737.1 - 0.00029 21.4 0.1 0.00063 20.3 0.1 1.5 1 0 0 1 1 1 1 Purple acid Phosphatase, N-terminal domain GpcrRhopsn4 PF10192.9 ELR25738.1 - 4.4e-46 157.4 14.8 2e-37 129.0 9.7 2.3 2 0 0 2 2 2 2 Rhodopsin-like GPCR transmembrane domain Lung_7-TM_R PF06814.13 ELR25738.1 - 0.0062 15.8 8.8 0.0062 15.8 8.8 1.5 2 0 0 2 2 2 1 Lung seven transmembrane receptor MAP17 PF15807.5 ELR25738.1 - 0.01 16.0 0.3 0.023 14.9 0.3 1.5 1 0 0 1 1 1 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 NARP1 PF12569.8 ELR25738.1 - 0.044 12.7 0.8 0.058 12.3 0.8 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 RXLR PF16810.5 ELR25738.1 - 3.1 8.2 4.0 0.65 10.4 0.4 1.6 2 0 0 2 2 2 0 RXLR phytopathogen effector protein, Avirulence activity GTA_holin_3TM PF11351.8 ELR25739.1 - 0.074 13.6 0.1 0.14 12.7 0.1 1.4 1 0 0 1 1 1 0 Holin of 3TMs, for gene-transfer release DUF5040 PF16443.5 ELR25739.1 - 0.11 11.9 0.0 0.2 11.1 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF5040) Importin_rep_4 PF18808.1 ELR25740.1 - 0.0001 22.5 0.5 0.0001 22.5 0.5 4.1 3 1 1 4 4 3 1 Importin repeat DNA_pol_phi PF04931.13 ELR25740.1 - 0.0059 14.8 13.3 0.0095 14.1 13.3 1.4 1 0 0 1 1 1 1 DNA polymerase phi HEAT PF02985.22 ELR25740.1 - 0.022 15.0 5.2 1.8 9.0 0.0 4.6 5 0 0 5 5 5 0 HEAT repeat RRN3 PF05327.11 ELR25740.1 - 0.056 12.0 4.0 0.091 11.3 4.0 1.3 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 CDC45 PF02724.14 ELR25740.1 - 0.063 11.6 12.1 0.09 11.1 12.1 1.1 1 0 0 1 1 1 0 CDC45-like protein CobT PF06213.12 ELR25740.1 - 0.89 8.9 14.0 0.33 10.3 10.6 2.0 2 0 0 2 2 2 0 Cobalamin biosynthesis protein CobT Pes-10 PF07149.11 ELR25740.1 - 1 8.4 8.9 1.8 7.5 8.9 1.5 1 0 0 1 1 1 0 Pes-10 Nop14 PF04147.12 ELR25740.1 - 1 7.5 16.0 1.5 6.9 16.0 1.3 1 0 0 1 1 1 0 Nop14-like family SDA1 PF05285.12 ELR25740.1 - 2.2 7.6 18.3 3.3 7.0 18.3 1.2 1 0 0 1 1 1 0 SDA1 BUD22 PF09073.10 ELR25740.1 - 3.3 6.9 17.4 6.2 6.1 17.4 1.4 1 0 0 1 1 1 0 BUD22 DUF4746 PF15928.5 ELR25740.1 - 9.1 5.6 11.6 15 4.9 11.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Ank_2 PF12796.7 ELR25741.1 - 3.8e-29 101.1 2.8 1.2e-12 48.3 0.1 3.1 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ELR25741.1 - 3.5e-18 65.7 0.7 1.4e-08 35.1 0.1 4.8 5 0 0 5 5 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 ELR25741.1 - 3.6e-15 54.5 0.8 3.7e-05 23.8 0.1 5.8 5 0 0 5 5 5 3 Ankyrin repeat Ank_5 PF13857.6 ELR25741.1 - 7.6e-12 45.2 3.4 3e-07 30.6 0.6 4.9 1 1 4 5 5 5 3 Ankyrin repeats (many copies) Ank PF00023.30 ELR25741.1 - 7.1e-11 42.0 3.3 0.00062 20.1 0.1 4.9 5 0 0 5 5 4 2 Ankyrin repeat F-box-like PF12937.7 ELR25741.1 - 1.4e-08 34.5 3.5 3.2e-08 33.3 3.5 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ELR25741.1 - 2.6e-05 24.0 0.2 4.8e-05 23.1 0.2 1.4 1 0 0 1 1 1 1 F-box domain RXT2_N PF08595.11 ELR25741.1 - 0.06 13.4 1.7 0.13 12.3 1.7 1.5 1 0 0 1 1 1 0 RXT2-like, N-terminal D123 PF07065.14 ELR25741.1 - 0.091 11.9 0.9 0.14 11.3 0.9 1.2 1 0 0 1 1 1 0 D123 CENP-B_dimeris PF09026.10 ELR25741.1 - 0.26 11.7 7.1 0.63 10.5 7.1 1.6 1 0 0 1 1 1 0 Centromere protein B dimerisation domain DNA_pol_phi PF04931.13 ELR25741.1 - 3.6 5.6 7.2 5.6 4.9 7.2 1.2 1 0 0 1 1 1 0 DNA polymerase phi FAM176 PF14851.6 ELR25741.1 - 3.8 7.2 6.0 0.5 10.0 1.5 1.8 2 0 0 2 2 2 0 FAM176 family Cwf_Cwc_15 PF04889.12 ELR25741.1 - 4.6 6.9 13.1 0.79 9.4 7.7 2.1 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein NOA36 PF06524.12 ELR25741.1 - 4.6 6.5 7.9 7.7 5.7 7.9 1.2 1 0 0 1 1 1 0 NOA36 protein DUF3574 PF12098.8 ELR25743.1 - 8.7e-30 102.6 0.0 1.2e-29 102.1 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3574) Peptidase_C1 PF00112.23 ELR25744.1 - 1e-60 205.6 1.8 1e-60 205.6 1.8 1.5 1 1 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.12 ELR25744.1 - 6.6e-09 36.1 0.5 1e-08 35.5 0.5 1.3 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Peptidase_C1_2 PF03051.15 ELR25744.1 - 0.0049 15.7 0.3 1 8.1 0.0 2.1 2 0 0 2 2 2 2 Peptidase C1-like family Myc_target_1 PF15179.6 ELR25745.1 - 0.047 13.6 0.0 0.062 13.2 0.0 1.2 1 0 0 1 1 1 0 Myc target protein 1 DUF1768 PF08719.11 ELR25746.1 - 3.3e-41 141.2 0.0 4.1e-41 140.9 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1768) Phage_30_3 PF08010.11 ELR25746.1 - 0.0022 17.8 0.0 0.0045 16.8 0.0 1.6 1 1 0 1 1 1 1 Bacteriophage protein GP30.3 SH3_6 PF12913.7 ELR25746.1 - 0.053 13.1 0.0 0.1 12.1 0.0 1.5 1 0 0 1 1 1 0 SH3 domain (SH3b1 type) PTCB-BRCT PF12738.7 ELR25747.1 - 6.7e-62 205.3 3.2 7.3e-19 67.5 0.0 8.1 8 0 0 8 8 8 5 twin BRCT domain BRCT PF00533.26 ELR25747.1 - 8.2e-49 163.9 0.1 3.3e-10 40.2 0.0 8.6 8 1 0 8 8 8 7 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 ELR25747.1 - 6.6e-47 157.8 0.0 1.4e-07 31.8 0.0 8.5 8 0 0 8 8 8 8 BRCT domain, a BRCA1 C-terminus domain LIG3_BRCT PF16759.5 ELR25747.1 - 3e-18 65.9 0.1 0.0049 17.1 0.0 7.5 7 0 0 7 7 7 5 DNA ligase 3 BRCT domain RTT107_BRCT_5 PF16770.5 ELR25747.1 - 1.3e-16 60.2 0.0 3.3e-06 26.9 0.0 6.4 7 0 0 7 7 7 3 Regulator of Ty1 transposition protein 107 BRCT domain DAP PF15228.6 ELR25749.1 - 0.0016 19.6 9.9 0.0022 19.1 9.9 1.2 1 0 0 1 1 1 1 Death-associated protein Prp31_C PF09785.9 ELR25749.1 - 0.087 13.8 2.4 0.13 13.2 2.4 1.4 1 1 0 1 1 1 0 Prp31 C terminal domain Barstar PF01337.18 ELR25750.1 - 1.3e-13 50.8 0.3 2.8e-13 49.7 0.3 1.6 1 0 0 1 1 1 1 Barstar (barnase inhibitor) F-box-like PF12937.7 ELR25750.1 - 0.00097 19.0 0.0 0.002 17.9 0.0 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ELR25750.1 - 0.19 11.7 0.0 0.43 10.5 0.0 1.6 1 0 0 1 1 1 0 F-box domain GRDP-like PF07173.12 ELR25751.1 - 2.5e-06 28.2 0.5 4.7e-05 24.1 0.9 2.5 2 1 1 3 3 3 1 Glycine-rich domain-containing protein-like # # Program: hmmscan # Version: 3.2.1 (June 2018) # Pipeline mode: SCAN # Query file: /oak/stanford/groups/akundaje/marinovg/genomes/Discosea/Acanthamoeba_castellanii_str._Neff-v1/GCA_000313135.1_Acastellanii.strNEFF_v1_protein.faa # Target file: /oak/stanford/groups/akundaje/marinovg/genomes/PFam/PFam32.0/Pfam-A.hmm # Option settings: /oak/stanford/groups/akundaje/marinovg/programs/hmmer-3.2.1/bin/hmmscan -o /oak/stanford/groups/akundaje/marinovg/genomes/Discosea/Acanthamoeba_castellanii_str._Neff-v1/GCA_000313135.1_Acastellanii.strNEFF_v1_protein.PFam32-A --tblout /oak/stanford/groups/akundaje/marinovg/genomes/Discosea/Acanthamoeba_castellanii_str._Neff-v1/GCA_000313135.1_Acastellanii.strNEFF_v1_protein.PFam32-A.tblout --cpu 20 /oak/stanford/groups/akundaje/marinovg/genomes/PFam/PFam32.0/Pfam-A.hmm /oak/stanford/groups/akundaje/marinovg/genomes/Discosea/Acanthamoeba_castellanii_str._Neff-v1/GCA_000313135.1_Acastellanii.strNEFF_v1_protein.faa # Current dir: /oak/stanford/groups/akundaje/marinovg/genomes # Date: Sun Mar 24 10:59:59 2019 # [ok]