# --- full sequence ---- --- best 1 domain ---- --- domain number estimation ---- # target name accession query name accession E-value score bias E-value score bias exp reg clu ov env dom rep inc description of target #------------------- ---------- -------------------- ---------- --------- ------ ----- --------- ------ ----- --- --- --- --- --- --- --- --- --------------------- Flavodoxin_1 PF00258.25 CAV17058.1 - 8.4e-27 94.1 0.0 9.6e-27 93.9 0.0 1.0 1 0 0 1 1 1 1 Flavodoxin MnmE_helical PF12631.7 CAV17059.1 - 4.9e-61 206.5 1.6 6e-61 206.2 1.6 1.1 1 0 0 1 1 1 1 MnmE helical domain TrmE_N PF10396.9 CAV17059.1 - 5.7e-36 123.3 0.0 4.3e-35 120.5 0.0 2.3 2 0 0 2 2 2 1 GTP-binding protein TrmE N-terminus MMR_HSR1 PF01926.23 CAV17059.1 - 1.5e-24 86.3 0.1 6.3e-24 84.3 0.0 2.0 2 0 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 CAV17059.1 - 6.8e-08 32.2 0.0 2.1e-07 30.6 0.0 1.8 2 0 0 2 2 2 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 CAV17059.1 - 4.9e-05 23.3 0.0 0.0048 16.8 0.0 2.4 2 0 0 2 2 2 1 RsgA GTPase Dynamin_N PF00350.23 CAV17059.1 - 0.0002 21.5 0.5 0.0021 18.1 0.1 2.5 2 1 1 3 3 3 1 Dynamin family ABC_tran PF00005.27 CAV17059.1 - 0.00074 20.0 0.0 0.0014 19.1 0.0 1.5 1 0 0 1 1 1 1 ABC transporter AIG1 PF04548.16 CAV17059.1 - 0.0011 18.4 0.0 0.0018 17.6 0.0 1.4 1 0 0 1 1 1 1 AIG1 family Ras PF00071.22 CAV17059.1 - 0.0033 17.0 0.0 0.007 16.0 0.0 1.6 1 1 0 1 1 1 1 Ras family Roc PF08477.13 CAV17059.1 - 0.0047 17.1 0.0 0.011 16.0 0.0 1.6 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Gtr1_RagA PF04670.12 CAV17059.1 - 0.011 15.1 0.0 0.033 13.5 0.0 1.7 2 0 0 2 2 2 0 Gtr1/RagA G protein conserved region AAA_28 PF13521.6 CAV17059.1 - 0.019 15.2 0.1 0.057 13.7 0.1 1.8 1 0 0 1 1 1 0 AAA domain Arf PF00025.21 CAV17059.1 - 0.037 13.5 0.0 0.088 12.3 0.0 1.6 1 0 0 1 1 1 0 ADP-ribosylation factor family SRPRB PF09439.10 CAV17059.1 - 0.043 13.2 0.0 0.082 12.3 0.0 1.4 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit AAA_18 PF13238.6 CAV17059.1 - 0.091 13.3 0.0 0.26 11.8 0.0 1.8 1 0 0 1 1 1 0 AAA domain DUF4702 PF15774.5 CAV17059.1 - 0.25 10.2 0.0 0.37 9.7 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4702) YidC_periplas PF14849.6 CAV17060.1 - 6.6e-84 282.2 0.5 8.2e-84 281.8 0.5 1.1 1 0 0 1 1 1 1 YidC periplasmic domain 60KD_IMP PF02096.20 CAV17060.1 - 1.8e-63 213.4 10.9 2.6e-63 212.8 10.9 1.3 1 0 0 1 1 1 1 60Kd inner membrane protein DUF2427 PF10348.9 CAV17060.1 - 0.049 13.4 1.2 0.15 11.8 1.2 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF2427) YidD PF01809.18 CAV17061.1 - 6.3e-28 96.5 0.2 7.2e-28 96.3 0.2 1.0 1 0 0 1 1 1 1 Putative membrane protein insertion efficiency factor Ribonuclease_P PF00825.18 CAV17062.1 - 1.2e-31 109.0 0.5 1.4e-31 108.8 0.5 1.0 1 0 0 1 1 1 1 Ribonuclease P CagY_I PF14585.6 CAV17062.1 - 0.037 14.1 0.0 5.7 7.1 0.0 2.7 3 0 0 3 3 3 0 CagY type 1 repeat Lipoprotein_22 PF17294.2 CAV17062.1 - 0.13 11.9 0.2 0.17 11.5 0.2 1.1 1 0 0 1 1 1 0 Uncharacterised lipoprotein family Ribosomal_L34 PF00468.17 CAV17063.1 - 5.9e-23 80.6 12.3 6.3e-23 80.5 12.3 1.0 1 0 0 1 1 1 1 Ribosomal protein L34 ABC_tran PF00005.27 CAV17064.1 - 8.2e-32 110.6 0.2 1.4e-31 109.9 0.2 1.3 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 CAV17064.1 - 8.3e-13 48.8 0.0 4.8e-06 26.6 0.0 2.2 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 CAV17064.1 - 1.3e-08 34.6 0.2 1.5e-07 31.1 0.2 2.0 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 CAV17064.1 - 1.3e-06 28.7 0.1 1.7e-05 25.1 0.1 2.1 1 1 0 1 1 1 1 AAA domain RsgA_GTPase PF03193.16 CAV17064.1 - 1.2e-05 25.3 0.3 0.00016 21.7 0.1 2.1 2 0 0 2 2 2 1 RsgA GTPase AAA_16 PF13191.6 CAV17064.1 - 3.5e-05 24.3 0.2 5.6e-05 23.6 0.2 1.4 1 1 0 1 1 1 1 AAA ATPase domain AAA_13 PF13166.6 CAV17064.1 - 9.2e-05 21.3 0.0 0.014 14.1 0.0 2.1 2 0 0 2 2 2 2 AAA domain ABC_ATPase PF09818.9 CAV17064.1 - 0.00025 20.0 0.5 0.054 12.3 0.1 2.9 2 1 0 2 2 2 1 Predicted ATPase of the ABC class AAA_30 PF13604.6 CAV17064.1 - 0.0003 20.6 0.2 0.00046 20.0 0.2 1.5 1 1 0 1 1 1 1 AAA domain AAA_29 PF13555.6 CAV17064.1 - 0.00039 20.1 0.0 0.00089 19.0 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_15 PF13175.6 CAV17064.1 - 0.001 18.9 1.1 0.053 13.2 0.2 2.1 1 1 0 2 2 2 1 AAA ATPase domain T2SSE PF00437.20 CAV17064.1 - 0.0015 17.7 0.7 0.0027 16.8 0.1 1.8 2 0 0 2 2 2 1 Type II/IV secretion system protein AAA_23 PF13476.6 CAV17064.1 - 0.0016 19.0 2.4 0.0034 17.9 2.5 1.6 1 1 0 1 1 1 1 AAA domain ATPase_2 PF01637.18 CAV17064.1 - 0.01 15.7 0.1 0.022 14.7 0.0 1.5 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea AAA_33 PF13671.6 CAV17064.1 - 0.016 15.4 0.0 0.043 14.0 0.0 1.7 2 0 0 2 2 2 0 AAA domain TniB PF05621.11 CAV17064.1 - 0.028 13.8 0.0 1.4 8.3 0.0 2.2 2 0 0 2 2 2 0 Bacterial TniB protein AAA_28 PF13521.6 CAV17064.1 - 0.04 14.2 1.3 0.079 13.2 0.5 1.9 2 1 0 2 2 2 0 AAA domain AAA_24 PF13479.6 CAV17064.1 - 0.04 13.6 0.6 0.055 13.2 0.1 1.6 2 1 0 2 2 1 0 AAA domain AAA_7 PF12775.7 CAV17064.1 - 0.051 13.1 0.0 0.1 12.1 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region TK PF00265.18 CAV17064.1 - 0.099 12.5 0.1 4.1 7.2 0.0 2.1 2 0 0 2 2 2 0 Thymidine kinase SbcCD_C PF13558.6 CAV17064.1 - 0.11 12.7 0.1 0.56 10.5 0.1 2.1 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit AAA_5 PF07728.14 CAV17064.1 - 0.11 12.5 0.0 4.5 7.3 0.0 2.3 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_14 PF13173.6 CAV17064.1 - 0.13 12.3 0.1 0.61 10.1 0.1 2.1 2 1 0 2 2 2 0 AAA domain MCM PF00493.23 CAV17064.1 - 0.13 11.3 1.3 1.8 7.6 0.1 2.2 1 1 1 2 2 2 0 MCM P-loop domain Ploopntkinase2 PF18747.1 CAV17064.1 - 0.15 11.3 0.0 0.23 10.7 0.0 1.4 1 0 0 1 1 1 0 P-loop Nucleotide Kinase2 AAA_19 PF13245.6 CAV17064.1 - 0.15 12.4 0.7 0.39 11.0 0.7 1.9 1 1 0 1 1 1 0 AAA domain MMR_HSR1 PF01926.23 CAV17064.1 - 0.19 11.8 1.1 0.69 10.0 1.1 2.2 1 1 0 1 1 1 0 50S ribosome-binding GTPase BPD_transp_1 PF00528.22 CAV17065.1 - 7.3e-17 61.7 18.0 7.3e-17 61.7 18.0 1.6 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component SBP_bac_3 PF00497.20 CAV17066.1 - 7.8e-56 189.0 0.5 9.5e-56 188.7 0.5 1.1 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 Lig_chan-Glu_bd PF10613.9 CAV17066.1 - 0.0003 21.0 0.2 0.011 16.0 0.1 2.6 2 1 0 2 2 2 1 Ligated ion channel L-glutamate- and glycine-binding site NMT1 PF09084.11 CAV17066.1 - 0.0025 17.8 0.3 0.012 15.6 0.1 1.9 1 1 1 2 2 2 1 NMT1/THI5 like Phosphonate-bd PF12974.7 CAV17066.1 - 0.0068 16.0 0.4 0.032 13.8 0.1 2.2 2 2 0 2 2 2 1 ABC transporter, phosphonate, periplasmic substrate-binding protein Bac_DnaA PF00308.18 CAV17067.1 - 7.5e-98 326.7 0.5 1.2e-97 326.1 0.5 1.3 1 0 0 1 1 1 1 Bacterial dnaA protein Bac_DnaA_C PF08299.11 CAV17067.1 - 5.2e-33 112.9 0.2 2.4e-32 110.8 0.0 2.1 2 0 0 2 2 2 1 Bacterial dnaA protein helix-turn-helix DnaA_N PF11638.8 CAV17067.1 - 5.7e-20 70.8 0.4 1.4e-19 69.5 0.4 1.8 1 0 0 1 1 1 1 DnaA N-terminal domain IstB_IS21 PF01695.17 CAV17067.1 - 3.5e-11 43.1 0.0 6.9e-11 42.2 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA PF00004.29 CAV17067.1 - 1.4e-06 28.8 0.2 7.2e-06 26.5 0.0 2.2 3 0 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 CAV17067.1 - 0.00071 20.0 0.3 0.0057 17.1 0.1 2.7 2 1 0 2 2 2 1 AAA ATPase domain AAA_14 PF13173.6 CAV17067.1 - 0.00093 19.2 0.1 0.013 15.6 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 CAV17067.1 - 0.011 16.0 3.9 1.2 9.4 1.0 3.5 2 1 0 2 2 2 0 AAA domain NACHT PF05729.12 CAV17067.1 - 0.011 15.7 0.0 0.032 14.1 0.0 1.8 1 0 0 1 1 1 0 NACHT domain AFG1_ATPase PF03969.16 CAV17067.1 - 0.014 14.3 0.1 0.035 13.0 0.1 1.7 1 1 0 1 1 1 0 AFG1-like ATPase ATPase_2 PF01637.18 CAV17067.1 - 0.024 14.6 0.0 0.067 13.1 0.0 1.8 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea Kinesin PF00225.23 CAV17067.1 - 0.028 13.3 0.0 0.057 12.3 0.0 1.5 1 1 0 1 1 1 0 Kinesin motor domain AAA_19 PF13245.6 CAV17067.1 - 0.036 14.4 0.2 0.13 12.6 0.0 2.1 2 1 0 2 2 1 0 AAA domain DUF815 PF05673.13 CAV17067.1 - 0.039 13.1 0.0 0.12 11.5 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF815) RNA_helicase PF00910.22 CAV17067.1 - 0.061 13.7 0.0 0.22 11.9 0.0 2.0 1 1 0 1 1 1 0 RNA helicase PhoH PF02562.16 CAV17067.1 - 0.089 12.2 0.0 0.22 11.0 0.0 1.6 2 0 0 2 2 2 0 PhoH-like protein DNA_pol3_beta PF00712.19 CAV17068.1 - 1.1e-43 148.2 0.9 2.1e-37 128.0 0.0 3.1 3 0 0 3 3 3 3 DNA polymerase III beta subunit, N-terminal domain DNA_pol3_beta_2 PF02767.16 CAV17068.1 - 1.5e-43 147.7 0.0 5e-35 120.2 0.0 2.7 3 0 0 3 3 3 2 DNA polymerase III beta subunit, central domain DNA_pol3_beta_3 PF02768.15 CAV17068.1 - 8.6e-39 132.1 1.3 2.2e-38 130.8 0.3 2.1 2 0 0 2 2 2 1 DNA polymerase III beta subunit, C-terminal domain SMC_N PF02463.19 CAV17069.1 - 9e-37 126.6 0.0 1.1e-36 126.4 0.0 1.1 1 0 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_15 PF13175.6 CAV17069.1 - 5.7e-10 39.4 0.0 3.1e-09 37.0 0.0 1.7 1 1 1 2 2 2 1 AAA ATPase domain AAA_21 PF13304.6 CAV17069.1 - 6.8e-10 39.2 0.0 9.3e-07 28.9 0.1 2.3 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 CAV17069.1 - 4.5e-08 33.9 0.5 7.9e-08 33.0 0.5 1.6 1 1 0 1 1 1 1 AAA domain AAA_29 PF13555.6 CAV17069.1 - 0.00018 21.1 0.1 0.0019 17.9 0.0 2.3 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_27 PF13514.6 CAV17069.1 - 0.001 18.7 0.6 0.016 14.8 0.0 2.6 3 0 0 3 3 3 1 AAA domain ABC_tran PF00005.27 CAV17069.1 - 0.028 14.9 0.2 0.13 12.8 0.2 2.2 1 1 0 1 1 1 0 ABC transporter AAA_16 PF13191.6 CAV17069.1 - 0.059 13.7 0.7 0.54 10.6 0.0 2.6 2 1 0 2 2 2 0 AAA ATPase domain cobW PF02492.19 CAV17069.1 - 0.075 12.6 0.0 0.16 11.6 0.0 1.5 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain OprD PF03573.13 CAV17069.1 - 0.094 11.7 0.0 0.14 11.2 0.0 1.2 1 0 0 1 1 1 0 outer membrane porin, OprD family DNA_gyraseB PF00204.25 CAV17070.1 - 7.3e-60 201.4 0.1 1.3e-59 200.6 0.1 1.5 1 0 0 1 1 1 1 DNA gyrase B GyrB_insert PF18053.1 CAV17070.1 - 8.6e-52 175.4 0.1 1.4e-51 174.7 0.1 1.4 1 0 0 1 1 1 1 DNA gyrase B subunit insert domain DNA_gyraseB_C PF00986.21 CAV17070.1 - 2.8e-30 104.3 0.6 7.1e-30 103.0 0.6 1.7 1 0 0 1 1 1 1 DNA gyrase B subunit, carboxyl terminus HATPase_c PF02518.26 CAV17070.1 - 3.3e-22 79.1 0.7 1.1e-21 77.5 0.2 2.1 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Toprim PF01751.22 CAV17070.1 - 7.8e-19 67.8 0.0 1.8e-18 66.6 0.0 1.7 1 0 0 1 1 1 1 Toprim domain HATPase_c_3 PF13589.6 CAV17070.1 - 0.00028 20.7 0.1 0.00067 19.5 0.1 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HSP20 PF00011.21 CAV17071.1 - 2.4e-19 69.4 0.3 3.1e-19 69.0 0.3 1.1 1 0 0 1 1 1 1 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 CAV17071.1 - 0.00014 21.3 0.0 0.00025 20.5 0.0 1.4 1 1 0 1 1 1 1 HSP20-like domain found in ArsA MKT1_C PF12246.8 CAV17071.1 - 0.055 12.7 0.1 0.08 12.2 0.1 1.2 1 0 0 1 1 1 0 Temperature dependent protein affecting M2 dsRNA replication DUF1727 PF08353.10 CAV17071.1 - 0.11 12.4 0.2 1.1 9.2 0.2 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF1727) Aminotran_1_2 PF00155.21 CAV17072.1 - 3.2e-26 92.4 0.0 2e-25 89.8 0.0 1.8 1 1 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.21 CAV17072.1 - 0.0041 16.5 0.0 0.0055 16.0 0.0 1.3 1 0 0 1 1 1 1 Beta-eliminating lyase Aminotran_MocR PF12897.7 CAV17072.1 - 0.011 14.6 0.0 0.023 13.5 0.0 1.4 1 1 0 1 1 1 0 Alanine-glyoxylate amino-transferase Flp_Fap PF04964.14 CAV17073.1 - 2.1e-09 37.0 0.5 2.9e-09 36.6 0.5 1.2 1 0 0 1 1 1 1 Flp/Fap pilin component TadF PF16964.5 CAV17073.1 - 0.02 14.6 0.0 0.023 14.5 0.0 1.1 1 0 0 1 1 1 0 Putative tight adherence pilin protein F Flp1_like PF16982.5 CAV17073.1 - 0.061 12.7 0.0 0.083 12.3 0.0 1.2 1 0 0 1 1 1 0 Putative Flagellin, Flp1-like, domain Peptidase_A24 PF01478.18 CAV17074.1 - 3.1e-11 43.6 11.6 4.6e-11 43.1 11.6 1.2 1 0 0 1 1 1 1 Type IV leader peptidase family DUF5080 PF16883.5 CAV17074.1 - 0.28 11.3 7.3 0.22 11.6 6.1 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF5080) DUF4131 PF13567.6 CAV17074.1 - 1.8 8.2 6.4 3.4 7.3 0.3 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) RcpC PF16976.5 CAV17075.1 - 9.1e-12 45.1 3.5 1.3e-11 44.6 3.5 1.2 1 0 0 1 1 1 1 Flp pilus assembly protein RcpC/CpaB Secretin PF00263.21 CAV17076.1 - 1.2e-39 135.6 0.2 3.9e-39 134.0 0.0 1.9 2 0 0 2 2 2 1 Bacterial type II and III secretion system protein T2SS-T3SS_pil_N PF13629.6 CAV17076.1 - 1.6e-15 56.5 0.0 4.1e-15 55.3 0.0 1.8 1 0 0 1 1 1 1 Pilus formation protein N terminal region BON PF04972.17 CAV17076.1 - 0.0011 19.3 1.6 0.0017 18.7 0.2 2.0 2 0 0 2 2 2 1 BON domain Pilus_CpaD PF09476.10 CAV17077.1 - 0.1 12.3 0.0 0.14 11.9 0.0 1.2 1 0 0 1 1 1 0 Pilus biogenesis CpaD protein (pilus_cpaD) ParA PF10609.9 CAV17078.1 - 4.8e-07 29.5 0.4 9.3e-07 28.5 0.4 1.5 1 0 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase CBP_BcsQ PF06564.12 CAV17078.1 - 0.00036 20.1 0.1 0.00059 19.4 0.1 1.3 1 0 0 1 1 1 1 Cellulose biosynthesis protein BcsQ AAA_31 PF13614.6 CAV17078.1 - 0.00044 20.2 0.4 0.00078 19.4 0.4 1.4 1 0 0 1 1 1 1 AAA domain CbiA PF01656.23 CAV17078.1 - 0.00073 19.6 0.1 0.0013 18.8 0.1 1.5 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain ArsA_ATPase PF02374.15 CAV17078.1 - 0.2 10.8 1.9 0.57 9.3 1.2 2.1 1 1 1 2 2 2 0 Anion-transporting ATPase T2SSE PF00437.20 CAV17079.1 - 2.3e-80 269.6 2.4 3e-80 269.2 2.4 1.1 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_28 PF13521.6 CAV17079.1 - 8.5e-05 22.8 0.2 0.00016 22.0 0.2 1.4 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 CAV17079.1 - 0.00023 21.6 0.2 0.0005 20.5 0.0 1.7 2 0 0 2 2 1 1 AAA ATPase domain ABC_tran PF00005.27 CAV17079.1 - 0.00043 20.8 0.0 0.0007 20.1 0.0 1.6 1 0 0 1 1 1 1 ABC transporter cobW PF02492.19 CAV17079.1 - 0.00086 18.9 0.1 0.005 16.5 0.1 2.1 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain Zeta_toxin PF06414.12 CAV17079.1 - 0.0013 18.1 0.0 0.0024 17.2 0.0 1.4 1 0 0 1 1 1 1 Zeta toxin AAA_23 PF13476.6 CAV17079.1 - 0.0023 18.4 0.0 0.0039 17.7 0.0 1.4 1 0 0 1 1 1 1 AAA domain ATP_bind_1 PF03029.17 CAV17079.1 - 0.0031 17.3 0.1 0.0056 16.5 0.1 1.4 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein AAA_29 PF13555.6 CAV17079.1 - 0.0033 17.1 0.1 0.0073 16.0 0.1 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain FtsK_SpoIIIE PF01580.18 CAV17079.1 - 0.0043 16.4 1.5 0.012 15.0 0.1 2.2 2 0 0 2 2 2 1 FtsK/SpoIIIE family AAA_2 PF07724.14 CAV17079.1 - 0.0055 16.8 0.0 0.016 15.3 0.0 1.8 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_30 PF13604.6 CAV17079.1 - 0.0061 16.3 0.0 0.012 15.3 0.0 1.5 1 0 0 1 1 1 1 AAA domain Septin PF00735.18 CAV17079.1 - 0.0079 15.5 0.1 0.012 14.9 0.1 1.2 1 0 0 1 1 1 1 Septin TrwB_AAD_bind PF10412.9 CAV17079.1 - 0.0084 15.1 0.9 0.027 13.4 0.1 1.9 1 1 1 2 2 2 1 Type IV secretion-system coupling protein DNA-binding domain AAA_19 PF13245.6 CAV17079.1 - 0.014 15.7 2.3 0.019 15.3 0.7 1.9 2 1 0 2 2 2 0 AAA domain KTI12 PF08433.10 CAV17079.1 - 0.015 14.8 0.0 0.032 13.7 0.0 1.5 1 0 0 1 1 1 0 Chromatin associated protein KTI12 DEAD PF00270.29 CAV17079.1 - 0.015 15.0 0.0 0.032 14.0 0.0 1.5 1 0 0 1 1 1 0 DEAD/DEAH box helicase AAA_22 PF13401.6 CAV17079.1 - 0.016 15.5 0.0 0.05 13.9 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 CAV17079.1 - 0.017 14.7 0.0 0.03 13.8 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region NACHT PF05729.12 CAV17079.1 - 0.018 15.0 0.1 0.036 14.0 0.1 1.5 1 0 0 1 1 1 0 NACHT domain AAA_18 PF13238.6 CAV17079.1 - 0.018 15.6 0.0 0.034 14.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain Mg_chelatase PF01078.21 CAV17079.1 - 0.026 13.9 0.1 0.058 12.8 0.1 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI RsgA_GTPase PF03193.16 CAV17079.1 - 0.038 13.9 0.0 0.083 12.8 0.0 1.5 1 0 0 1 1 1 0 RsgA GTPase CbiA PF01656.23 CAV17079.1 - 0.053 13.6 0.0 0.092 12.8 0.0 1.5 1 0 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain Viral_helicase1 PF01443.18 CAV17079.1 - 0.058 13.1 0.1 0.11 12.2 0.1 1.4 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase Sigma54_activat PF00158.26 CAV17079.1 - 0.059 13.1 0.0 0.13 12.0 0.0 1.5 1 0 0 1 1 1 0 Sigma-54 interaction domain DUF2075 PF09848.9 CAV17079.1 - 0.059 12.6 0.1 0.11 11.7 0.0 1.4 2 0 0 2 2 1 0 Uncharacterized conserved protein (DUF2075) MCM PF00493.23 CAV17079.1 - 0.059 12.5 0.1 0.11 11.6 0.1 1.3 1 0 0 1 1 1 0 MCM P-loop domain NTPase_1 PF03266.15 CAV17079.1 - 0.076 12.9 0.1 0.22 11.4 0.1 1.8 1 0 0 1 1 1 0 NTPase MMR_HSR1 PF01926.23 CAV17079.1 - 0.088 12.9 0.0 0.18 11.9 0.0 1.5 1 0 0 1 1 1 0 50S ribosome-binding GTPase PduV-EutP PF10662.9 CAV17079.1 - 0.11 12.3 0.0 0.22 11.3 0.0 1.5 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation APS_kinase PF01583.20 CAV17079.1 - 0.11 12.4 0.1 0.22 11.4 0.1 1.4 1 0 0 1 1 1 0 Adenylylsulphate kinase IIGP PF05049.13 CAV17079.1 - 0.12 11.4 0.0 0.22 10.5 0.0 1.3 1 0 0 1 1 1 0 Interferon-inducible GTPase (IIGP) dNK PF01712.19 CAV17079.1 - 0.15 11.9 0.0 0.24 11.2 0.0 1.3 1 0 0 1 1 1 0 Deoxynucleoside kinase T2SSF PF00482.23 CAV17080.1 - 1.6e-20 73.3 0.4 1.4e-19 70.2 0.0 2.3 2 0 0 2 2 2 1 Type II secretion system (T2SS), protein F S_4TM PF18159.1 CAV17080.1 - 0.007 15.7 0.1 0.012 15.0 0.1 1.3 1 0 0 1 1 1 1 SMODS-associating 4TM effector domain MP PF01107.18 CAV17080.1 - 0.044 13.3 0.0 0.077 12.6 0.0 1.3 1 0 0 1 1 1 0 Viral movement protein (MP) DUF2207 PF09972.9 CAV17080.1 - 0.074 11.8 1.0 0.29 9.9 0.2 1.9 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) DUF687 PF05095.12 CAV17080.1 - 0.17 10.4 0.0 0.24 9.9 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF687) T2SSF PF00482.23 CAV17081.1 - 1e-14 54.6 2.5 1e-14 54.6 2.5 2.5 2 0 0 2 2 2 1 Type II secretion system (T2SS), protein F TPR_2 PF07719.17 CAV17082.1 - 0.00037 20.4 4.2 2.7 8.3 0.0 4.6 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_19 PF14559.6 CAV17082.1 - 0.0033 17.9 5.1 0.32 11.5 0.6 3.0 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.6 CAV17082.1 - 0.0036 17.6 8.7 0.77 10.1 0.8 3.8 3 1 0 3 3 3 2 Tetratricopeptide repeat ANAPC3 PF12895.7 CAV17082.1 - 0.0094 16.2 1.6 0.026 14.7 0.0 2.4 2 1 0 3 3 3 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_20 PF14561.6 CAV17082.1 - 0.011 16.0 4.8 0.24 11.7 0.1 3.4 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_14 PF13428.6 CAV17082.1 - 0.012 16.4 1.1 5.6 8.1 0.1 3.6 2 2 1 3 3 3 0 Tetratricopeptide repeat TPR_16 PF13432.6 CAV17082.1 - 0.016 15.9 6.2 0.19 12.4 0.4 3.0 2 1 1 3 3 3 0 Tetratricopeptide repeat LPAM_1 PF08139.12 CAV17082.1 - 0.023 15.2 1.2 0.053 14.0 1.2 1.6 1 0 0 1 1 1 0 Prokaryotic membrane lipoprotein lipid attachment site Coatomer_E PF04733.14 CAV17082.1 - 0.024 14.0 2.0 0.063 12.7 0.2 2.0 1 1 1 2 2 2 0 Coatomer epsilon subunit TPR_8 PF13181.6 CAV17082.1 - 0.057 13.7 9.1 1.9 8.9 0.1 4.5 6 0 0 6 6 5 0 Tetratricopeptide repeat Uteroglobin PF01099.17 CAV17082.1 - 0.088 13.2 0.2 0.23 11.8 0.2 1.7 1 0 0 1 1 1 0 Uteroglobin family TPR_6 PF13174.6 CAV17082.1 - 0.61 10.8 0.0 0.61 10.8 0.0 4.0 5 0 0 5 5 4 0 Tetratricopeptide repeat TPR_1 PF00515.28 CAV17082.1 - 0.94 9.4 6.0 1.7 8.6 0.0 3.7 4 0 0 4 4 3 0 Tetratricopeptide repeat TPR_7 PF13176.6 CAV17082.1 - 4.5 7.5 7.9 4.3 7.6 0.1 4.1 5 0 0 5 5 5 0 Tetratricopeptide repeat TadE PF07811.12 CAV17083.1 - 0.00051 20.3 0.6 0.001 19.3 0.6 1.5 1 0 0 1 1 1 1 TadE-like protein Imm59 PF15597.6 CAV17083.1 - 0.01 16.3 0.3 0.02 15.4 0.0 1.6 2 0 0 2 2 2 0 Immunity protein 59 TadF PF16964.5 CAV17084.1 - 4.9e-67 225.3 0.1 5.5e-67 225.2 0.1 1.0 1 0 0 1 1 1 1 Putative tight adherence pilin protein F Flp_Fap PF04964.14 CAV17084.1 - 0.022 14.5 0.0 0.044 13.6 0.0 1.6 1 0 0 1 1 1 0 Flp/Fap pilin component Flagellin_C PF00700.21 CAV17084.1 - 0.13 12.6 0.4 6.1 7.3 0.1 2.1 2 0 0 2 2 2 0 Bacterial flagellin C-terminal helical region VWA_2 PF13519.6 CAV17085.1 - 7.7e-08 32.9 0.0 0.015 15.9 0.1 2.8 2 0 0 2 2 2 2 von Willebrand factor type A domain VWA PF00092.28 CAV17085.1 - 2.9e-06 27.6 0.6 0.091 13.0 0.2 2.5 2 0 0 2 2 2 2 von Willebrand factor type A domain Tad PF13400.6 CAV17085.1 - 2.4e-05 24.5 2.2 4.3e-05 23.7 2.2 1.4 1 0 0 1 1 1 1 Putative Flp pilus-assembly TadE/G-like VWA_CoxE PF05762.14 CAV17085.1 - 0.011 15.2 0.0 1 8.7 0.0 2.3 2 0 0 2 2 2 0 VWA domain containing CoxE-like protein TadE PF07811.12 CAV17085.1 - 0.017 15.4 1.6 0.028 14.7 1.6 1.4 1 0 0 1 1 1 0 TadE-like protein OmpA PF00691.20 CAV17086.1 - 1.9e-17 63.4 0.3 3.4e-17 62.6 0.1 1.5 2 0 0 2 2 2 1 OmpA family HATPase_c PF02518.26 CAV17087.1 - 7.4e-12 45.8 0.0 1.6e-11 44.7 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_5 PF14501.6 CAV17087.1 - 3.8e-08 33.1 0.0 7.8e-08 32.1 0.0 1.6 1 0 0 1 1 1 1 GHKL domain DUF4446 PF14584.6 CAV17087.1 - 0.028 14.4 0.3 0.081 12.9 0.1 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF4446) DUF4179 PF13786.6 CAV17087.1 - 0.062 13.8 1.1 6.8 7.2 0.3 2.9 2 1 0 2 2 2 0 Domain of unknown function (DUF4179) HATPase_c_2 PF13581.6 CAV17087.1 - 0.1 12.6 0.0 0.22 11.5 0.0 1.5 1 0 0 1 1 1 0 Histidine kinase-like ATPase domain Microtub_bind PF13931.6 CAV17087.1 - 0.39 11.1 3.5 0.26 11.7 1.0 1.9 2 0 0 2 2 2 0 Kinesin-associated microtubule-binding SKG6 PF08693.10 CAV17087.1 - 0.95 8.9 3.2 2.3 7.7 3.2 1.6 1 0 0 1 1 1 0 Transmembrane alpha-helix domain Response_reg PF00072.24 CAV17088.1 - 2.9e-25 88.6 0.1 4.8e-25 87.9 0.1 1.3 1 0 0 1 1 1 1 Response regulator receiver domain Trans_reg_C PF00486.28 CAV17088.1 - 3.1e-19 68.8 1.9 3.9e-19 68.5 0.2 2.0 2 0 0 2 2 2 1 Transcriptional regulatory protein, C terminal OKR_DC_1_N PF03709.15 CAV17088.1 - 0.0034 17.6 0.0 0.0086 16.3 0.0 1.6 1 0 0 1 1 1 1 Orn/Lys/Arg decarboxylase, N-terminal domain EnY2 PF10163.9 CAV17088.1 - 0.093 13.1 0.5 1.3 9.5 0.0 2.7 3 1 0 3 3 3 0 Transcription factor e(y)2 tRNA_synt_2f PF02092.17 CAV17089.1 - 1.9e-204 680.5 0.1 1.9e-204 680.5 0.1 1.3 2 0 0 2 2 2 1 Glycyl-tRNA synthetase beta subunit DALR_1 PF05746.15 CAV17089.1 - 1.9e-10 41.0 1.7 3.8e-10 40.0 0.7 2.0 2 0 0 2 2 2 1 DALR anticodon binding domain tRNA-synt_2e PF02091.15 CAV17090.1 - 1.5e-148 493.5 0.0 1.7e-148 493.3 0.0 1.0 1 0 0 1 1 1 1 Glycyl-tRNA synthetase alpha subunit Orthopox_F8 PF05886.11 CAV17090.1 - 0.14 12.3 0.0 0.3 11.2 0.0 1.5 1 0 0 1 1 1 0 Orthopoxvirus F8 protein UPF0016 PF01169.19 CAV17091.1 - 2e-41 140.2 15.2 1.2e-20 73.6 3.9 2.1 2 0 0 2 2 2 2 Uncharacterized protein family UPF0016 TauE PF01925.19 CAV17091.1 - 5.1e-06 26.3 11.4 0.00019 21.2 2.1 2.1 2 0 0 2 2 2 2 Sulfite exporter TauE/SafE DUF3040 PF11239.8 CAV17092.1 - 0.031 14.6 1.0 0.048 13.9 1.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3040) TusA PF01206.17 CAV17093.1 - 3.3e-23 81.3 0.0 3.7e-23 81.1 0.0 1.0 1 0 0 1 1 1 1 Sulfurtransferase TusA LysR_substrate PF03466.20 CAV17094.1 - 4.7e-23 81.7 1.1 7.9e-23 80.9 1.1 1.3 1 0 0 1 1 1 1 LysR substrate binding domain HTH_1 PF00126.27 CAV17094.1 - 4.5e-15 55.3 0.8 8.1e-15 54.5 0.8 1.5 1 0 0 1 1 1 1 Bacterial regulatory helix-turn-helix protein, lysR family MarR_2 PF12802.7 CAV17094.1 - 0.023 14.6 0.2 0.045 13.6 0.2 1.5 1 0 0 1 1 1 0 MarR family Reo_sigmaC_M PF17750.1 CAV17094.1 - 0.56 10.1 2.6 0.97 9.3 0.5 2.4 2 0 0 2 2 2 0 Reovirus sigma C capsid protein triple beta spiral ADH_zinc_N PF00107.26 CAV17095.1 - 1.3e-11 44.6 0.0 2.2e-11 43.8 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 CAV17095.1 - 6.2e-05 22.9 0.0 0.00023 21.0 0.0 1.9 1 1 1 2 2 2 1 Alcohol dehydrogenase GroES-like domain Epimerase PF01370.21 CAV17095.1 - 0.0019 17.7 0.1 0.0027 17.2 0.1 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family ELFV_dehydrog PF00208.21 CAV17095.1 - 0.016 14.9 0.4 0.027 14.2 0.4 1.3 1 0 0 1 1 1 0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase adh_short PF00106.25 CAV17095.1 - 0.095 12.1 0.5 0.18 11.3 0.5 1.4 1 0 0 1 1 1 0 short chain dehydrogenase NmrA PF05368.13 CAV17095.1 - 0.14 11.7 0.2 0.26 10.8 0.2 1.5 1 0 0 1 1 1 0 NmrA-like family Thiolase_N PF00108.23 CAV17096.1 - 3.2e-84 282.3 0.2 4.5e-84 281.9 0.2 1.2 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 CAV17096.1 - 2.2e-48 163.0 0.3 2.2e-48 163.0 0.3 1.8 2 0 0 2 2 2 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.26 CAV17096.1 - 0.0006 19.5 0.5 0.0006 19.5 0.5 2.2 3 1 0 4 4 4 1 Beta-ketoacyl synthase, N-terminal domain ACP_syn_III PF08545.10 CAV17096.1 - 0.038 13.9 0.1 4.2 7.3 0.0 2.4 2 0 0 2 2 2 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III 3HCDH_N PF02737.18 CAV17097.1 - 2.8e-58 196.8 0.1 6.9e-58 195.5 0.1 1.7 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain ECH_1 PF00378.20 CAV17097.1 - 1.5e-40 139.1 0.0 2.6e-40 138.3 0.0 1.4 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase 3HCDH PF00725.22 CAV17097.1 - 1.2e-33 115.5 2.1 5.1e-24 84.7 0.3 3.2 4 0 0 4 4 4 2 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain ECH_2 PF16113.5 CAV17097.1 - 1.6e-20 73.9 0.0 2.4e-20 73.3 0.0 1.2 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase NAD_binding_2 PF03446.15 CAV17097.1 - 0.083 13.1 0.1 0.17 12.0 0.1 1.5 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase UPF0029 PF01205.19 CAV17098.1 - 1.2e-26 93.1 0.0 1.8e-26 92.5 0.0 1.3 1 0 0 1 1 1 1 Uncharacterized protein family UPF0029 DUF1949 PF09186.11 CAV17098.1 - 3.2e-10 39.7 0.1 5.2e-10 39.1 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1949) Endotoxin_C2 PF18449.1 CAV17098.1 - 0.15 12.4 1.2 15 6.1 0.1 2.3 2 0 0 2 2 2 0 Delta endotoxin TrkH PF02386.16 CAV17099.1 - 1.7e-91 307.2 16.1 2.4e-91 306.7 16.1 1.1 1 0 0 1 1 1 1 Cation transport protein TMEM192 PF14802.6 CAV17099.1 - 0.062 12.4 0.3 0.15 11.1 0.3 1.6 1 0 0 1 1 1 0 TMEM192 family NapE PF06796.11 CAV17099.1 - 0.26 10.8 3.2 6.4 6.4 0.0 3.7 3 0 0 3 3 3 0 Periplasmic nitrate reductase protein NapE DUF3951 PF13131.6 CAV17099.1 - 1.9 8.7 7.8 0.2 11.9 0.5 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3951) Flavodoxin_5 PF12724.7 CAV17100.1 - 2.3e-49 167.3 0.0 2.8e-49 167.1 0.0 1.1 1 0 0 1 1 1 1 Flavodoxin domain Flavodoxin_3 PF12641.7 CAV17100.1 - 4.7e-08 32.9 0.0 6.2e-08 32.5 0.0 1.2 1 0 0 1 1 1 1 Flavodoxin domain Flavodoxin_1 PF00258.25 CAV17100.1 - 0.006 16.8 0.0 0.013 15.7 0.0 1.5 2 0 0 2 2 2 1 Flavodoxin OLF PF02191.16 CAV17100.1 - 0.013 15.0 0.1 0.5 9.9 0.0 2.1 2 0 0 2 2 2 0 Olfactomedin-like domain Band_7 PF01145.25 CAV17100.1 - 0.18 11.8 0.0 0.36 10.8 0.0 1.5 1 1 0 1 1 1 0 SPFH domain / Band 7 family LysR_substrate PF03466.20 CAV17101.1 - 5.1e-36 124.0 0.0 7.1e-36 123.5 0.0 1.2 1 0 0 1 1 1 1 LysR substrate binding domain HTH_1 PF00126.27 CAV17101.1 - 2.6e-18 65.7 0.0 4.9e-18 64.8 0.0 1.5 1 0 0 1 1 1 1 Bacterial regulatory helix-turn-helix protein, lysR family HTH_30 PF13556.6 CAV17101.1 - 0.0015 18.3 0.0 0.0027 17.5 0.0 1.4 1 0 0 1 1 1 1 PucR C-terminal helix-turn-helix domain MarR PF01047.22 CAV17101.1 - 0.032 14.1 0.1 0.071 13.1 0.1 1.6 1 1 0 1 1 1 0 MarR family HTH_23 PF13384.6 CAV17101.1 - 0.052 13.4 0.0 0.11 12.3 0.0 1.5 1 0 0 1 1 1 0 Homeodomain-like domain LNP1 PF15419.6 CAV17101.1 - 0.059 13.6 0.1 0.092 13.0 0.1 1.2 1 0 0 1 1 1 0 Leukemia NUP98 fusion partner 1 Chor_lyase PF04345.13 CAV17101.1 - 0.07 12.8 0.1 0.11 12.2 0.1 1.3 1 0 0 1 1 1 0 Chorismate lyase MarR_2 PF12802.7 CAV17101.1 - 0.081 12.8 0.0 0.15 11.9 0.0 1.4 1 0 0 1 1 1 0 MarR family HTH_5 PF01022.20 CAV17101.1 - 0.11 12.4 0.2 0.2 11.5 0.2 1.4 1 0 0 1 1 1 0 Bacterial regulatory protein, arsR family Microtub_bd PF16796.5 CAV17101.1 - 0.18 11.8 0.0 0.33 10.9 0.0 1.4 1 0 0 1 1 1 0 Microtubule binding IlvN PF07991.12 CAV17102.1 - 2.4e-58 196.4 0.1 3.4e-58 195.9 0.1 1.2 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain IlvC PF01450.19 CAV17102.1 - 1.2e-44 152.1 0.2 8.4e-25 87.7 0.0 2.5 2 1 0 2 2 2 2 Acetohydroxy acid isomeroreductase, catalytic domain 2-Hacid_dh_C PF02826.19 CAV17102.1 - 5.2e-05 22.7 0.0 9.5e-05 21.8 0.0 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain ApbA PF02558.16 CAV17102.1 - 0.0086 15.7 0.0 0.018 14.7 0.0 1.5 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA NAD_binding_2 PF03446.15 CAV17102.1 - 0.039 14.1 0.0 0.075 13.2 0.0 1.4 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase Peptidase_S78 PF04586.17 CAV17102.1 - 0.066 13.4 0.0 2 8.5 0.0 2.3 2 0 0 2 2 2 0 Caudovirus prohead serine protease NAD_binding_7 PF13241.6 CAV17102.1 - 0.11 13.0 0.0 0.47 10.9 0.0 2.0 2 0 0 2 2 2 0 Putative NAD(P)-binding BMFP PF04380.13 CAV17103.1 - 1.4e-27 96.0 3.4 1.5e-27 95.8 3.4 1.0 1 0 0 1 1 1 1 Membrane fusogenic activity ApoC-I PF04691.12 CAV17103.1 - 0.003 17.4 0.1 0.12 12.3 0.0 2.3 2 1 0 2 2 2 1 Apolipoprotein C-I (ApoC-1) Cortex-I_coil PF09304.10 CAV17103.1 - 0.023 14.9 1.5 4.4 7.6 0.3 2.1 1 1 1 2 2 2 0 Cortexillin I, coiled coil DUF3052 PF11253.8 CAV17103.1 - 0.025 14.5 0.4 0.027 14.4 0.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3052) Phasin PF05597.11 CAV17103.1 - 0.061 13.3 2.8 0.28 11.2 2.8 1.9 1 1 0 1 1 1 0 Poly(hydroxyalcanoate) granule associated protein (phasin) HSBP1 PF06825.12 CAV17103.1 - 0.065 13.1 3.0 0.2 11.6 1.1 2.6 1 1 0 2 2 2 0 Heat shock factor binding protein 1 Gal4_dimer PF03902.13 CAV17103.1 - 0.094 12.9 1.1 1.1 9.5 0.1 2.3 2 1 0 2 2 2 0 Gal4-like dimerisation domain KxDL PF10241.9 CAV17103.1 - 0.13 12.6 3.1 0.48 10.7 3.1 1.9 1 1 0 1 1 1 0 Uncharacterized conserved protein Matrilin_ccoil PF10393.9 CAV17103.1 - 0.25 11.2 3.5 0.42 10.5 0.5 2.5 3 0 0 3 3 3 0 Trimeric coiled-coil oligomerisation domain of matrilin ACR_tran PF00873.19 CAV17104.1 - 2.8e-274 912.6 31.4 3.2e-274 912.4 31.4 1.0 1 0 0 1 1 1 1 AcrB/AcrD/AcrF family MMPL PF03176.15 CAV17104.1 - 1.5e-12 47.1 29.7 1.5e-08 34.0 10.6 2.4 2 0 0 2 2 2 2 MMPL family SecD_SecF PF02355.16 CAV17104.1 - 0.00029 20.3 29.9 0.0016 17.8 8.4 2.8 2 0 0 2 2 2 2 Protein export membrane protein HlyD_D23 PF16576.5 CAV17105.1 - 2.5e-24 85.7 0.0 4.4e-24 84.9 0.0 1.4 1 0 0 1 1 1 1 Barrel-sandwich domain of CusB or HlyD membrane-fusion HlyD_3 PF13437.6 CAV17105.1 - 1.7e-18 67.2 0.4 1.6e-17 64.1 0.1 2.5 2 0 0 2 2 2 1 HlyD family secretion protein HlyD PF00529.20 CAV17105.1 - 2.4e-08 33.8 0.3 3.5e-07 30.0 0.3 2.7 1 1 0 1 1 1 1 HlyD membrane-fusion protein of T1SS Biotin_lipoyl_2 PF13533.6 CAV17105.1 - 3.2e-05 23.7 1.9 0.002 17.9 0.1 3.3 3 0 0 3 3 3 1 Biotin-lipoyl like OEP PF02321.18 CAV17105.1 - 0.00044 20.1 0.5 0.00092 19.1 0.5 1.5 1 0 0 1 1 1 1 Outer membrane efflux protein Biotin_lipoyl PF00364.22 CAV17105.1 - 0.013 15.3 0.4 1.9 8.4 0.0 3.2 3 1 0 3 3 3 0 Biotin-requiring enzyme TarH PF02203.15 CAV17105.1 - 0.19 11.6 0.1 0.19 11.6 0.1 1.5 2 0 0 2 2 2 0 Tar ligand binding domain homologue TetR_N PF00440.23 CAV17106.1 - 5.1e-19 67.8 0.5 9e-19 67.0 0.5 1.4 1 0 0 1 1 1 1 Bacterial regulatory proteins, tetR family TetR_C_10 PF16295.5 CAV17106.1 - 1e-08 35.6 0.0 1.8e-08 34.8 0.0 1.4 1 0 0 1 1 1 1 Tetracyclin repressor-like, C-terminal domain HTH_Tnp_1_2 PF13022.6 CAV17106.1 - 0.00084 19.5 0.1 0.0022 18.1 0.0 1.7 2 0 0 2 2 2 1 Helix-turn-helix of insertion element transposase HTH_psq PF05225.16 CAV17106.1 - 0.0013 18.4 0.2 0.0037 17.0 0.0 1.8 2 0 0 2 2 2 1 helix-turn-helix, Psq domain HTH_3 PF01381.22 CAV17106.1 - 0.0063 16.6 0.0 0.012 15.6 0.0 1.5 1 0 0 1 1 1 1 Helix-turn-helix TetR_C_24 PF17932.1 CAV17106.1 - 0.0076 16.5 0.2 0.21 11.8 0.0 2.3 1 1 1 2 2 2 1 Tetracyclin repressor-like, C-terminal domain HTH_23 PF13384.6 CAV17106.1 - 0.0085 15.9 0.0 0.018 14.8 0.0 1.5 1 0 0 1 1 1 1 Homeodomain-like domain HTH_40 PF14493.6 CAV17106.1 - 0.0095 16.4 0.2 0.11 12.9 0.1 2.7 2 1 0 2 2 2 1 Helix-turn-helix domain HTH_7 PF02796.15 CAV17106.1 - 0.011 15.8 0.0 0.022 14.8 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain of resolvase TnsD PF15978.5 CAV17106.1 - 0.024 13.6 0.0 0.031 13.3 0.0 1.1 1 0 0 1 1 1 0 Tn7-like transposition protein D TetR_C_29 PF17938.1 CAV17106.1 - 0.028 14.5 0.0 0.076 13.1 0.0 1.8 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain HTH_38 PF13936.6 CAV17106.1 - 0.063 13.0 0.0 0.28 11.0 0.0 2.0 2 0 0 2 2 2 0 Helix-turn-helix domain HTH_Tnp_ISL3 PF13542.6 CAV17106.1 - 0.09 12.2 0.0 0.17 11.3 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain of transposase family ISL3 UvrD_C PF13361.6 CAV17107.1 - 2.1e-77 260.9 1.4 2.1e-77 260.9 1.4 2.7 2 1 0 2 2 2 1 UvrD-like helicase C-terminal domain UvrD-helicase PF00580.21 CAV17107.1 - 8.8e-76 255.4 0.5 7.2e-75 252.4 0.5 2.3 1 1 0 1 1 1 1 UvrD/REP helicase N-terminal domain AAA_19 PF13245.6 CAV17107.1 - 2.9e-36 125.0 0.1 5.4e-36 124.1 0.1 1.5 1 0 0 1 1 1 1 AAA domain UvrD_C_2 PF13538.6 CAV17107.1 - 1.2e-09 37.8 0.0 4.5e-09 36.0 0.0 1.9 1 1 0 1 1 1 1 UvrD-like helicase C-terminal domain AAA_30 PF13604.6 CAV17107.1 - 1.5e-09 37.9 0.7 7.5e-05 22.5 0.1 3.0 3 0 0 3 3 3 2 AAA domain Viral_helicase1 PF01443.18 CAV17107.1 - 6e-05 22.9 0.2 0.13 12.0 0.0 3.3 3 0 0 3 3 3 2 Viral (Superfamily 1) RNA helicase AAA_12 PF13087.6 CAV17107.1 - 0.008 15.8 1.2 0.64 9.6 0.0 3.4 3 1 0 3 3 3 1 AAA domain PhoH PF02562.16 CAV17107.1 - 0.14 11.6 0.6 1.8 7.9 0.0 2.8 3 0 0 3 3 3 0 PhoH-like protein Cytochrome_CBB3 PF13442.6 CAV17108.1 - 1.3e-15 57.5 1.1 2.3e-15 56.7 0.8 1.5 2 0 0 2 2 2 1 Cytochrome C oxidase, cbb3-type, subunit III Cytochrom_C PF00034.21 CAV17108.1 - 0.00023 22.2 0.4 0.0017 19.4 0.2 2.1 2 0 0 2 2 2 1 Cytochrome c ABC_tran PF00005.27 CAV17109.1 - 1.4e-66 223.2 0.0 1.3e-34 119.7 0.0 2.2 2 0 0 2 2 2 2 ABC transporter oligo_HPY PF08352.12 CAV17109.1 - 3.3e-14 53.1 0.4 1.7e-07 31.7 0.1 2.6 2 0 0 2 2 2 2 Oligopeptide/dipeptide transporter, C-terminal region AAA_21 PF13304.6 CAV17109.1 - 1.8e-12 47.7 5.2 0.0015 18.4 0.0 4.2 2 2 0 4 4 4 3 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 CAV17109.1 - 9.1e-12 44.9 0.0 6.4e-07 29.0 0.0 2.4 2 1 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 CAV17109.1 - 1.4e-09 37.5 0.3 0.0016 18.1 0.1 2.4 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_22 PF13401.6 CAV17109.1 - 5.1e-08 33.3 5.1 0.0088 16.3 1.3 4.1 2 2 0 2 2 2 2 AAA domain AAA_16 PF13191.6 CAV17109.1 - 8.2e-07 29.6 0.5 0.026 14.9 0.2 2.8 2 1 0 2 2 2 2 AAA ATPase domain PRK PF00485.18 CAV17109.1 - 2.9e-06 27.1 0.0 0.025 14.3 0.0 2.3 2 0 0 2 2 2 2 Phosphoribulokinase / Uridine kinase family RsgA_GTPase PF03193.16 CAV17109.1 - 3.2e-06 27.1 0.1 0.058 13.3 0.0 2.3 2 0 0 2 2 2 2 RsgA GTPase AAA PF00004.29 CAV17109.1 - 1.7e-05 25.3 0.1 0.036 14.5 0.1 3.4 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) TniB PF05621.11 CAV17109.1 - 9.8e-05 21.8 0.5 0.025 14.0 0.0 3.7 4 0 0 4 4 4 1 Bacterial TniB protein AAA_23 PF13476.6 CAV17109.1 - 0.00019 22.0 0.0 0.23 11.9 0.0 2.5 2 0 0 2 2 2 2 AAA domain Mg_chelatase PF01078.21 CAV17109.1 - 0.00042 19.8 0.2 0.052 12.9 0.0 3.0 3 0 0 3 3 3 1 Magnesium chelatase, subunit ChlI AAA_30 PF13604.6 CAV17109.1 - 0.00096 18.9 0.4 1.4 8.6 0.1 2.7 3 0 0 3 3 3 2 AAA domain APS_kinase PF01583.20 CAV17109.1 - 0.0014 18.5 0.2 0.96 9.3 0.0 2.4 2 0 0 2 2 2 1 Adenylylsulphate kinase MMR_HSR1 PF01926.23 CAV17109.1 - 0.0014 18.7 2.6 0.7 10.0 0.2 2.9 2 1 0 2 2 2 2 50S ribosome-binding GTPase AAA_18 PF13238.6 CAV17109.1 - 0.0019 18.7 0.0 1.4 9.5 0.0 2.5 2 0 0 2 2 2 1 AAA domain NB-ARC PF00931.22 CAV17109.1 - 0.005 16.1 0.9 2.9 7.0 0.1 2.5 2 0 0 2 2 2 2 NB-ARC domain IstB_IS21 PF01695.17 CAV17109.1 - 0.0051 16.6 0.2 1.9 8.2 0.0 2.9 3 0 0 3 3 3 1 IstB-like ATP binding protein AAA_25 PF13481.6 CAV17109.1 - 0.0082 15.7 0.3 2 7.9 0.1 3.3 2 1 0 2 2 2 1 AAA domain RNA_helicase PF00910.22 CAV17109.1 - 0.0089 16.4 0.0 3.4 8.1 0.0 2.6 2 0 0 2 2 2 1 RNA helicase DUF87 PF01935.17 CAV17109.1 - 0.0091 16.1 1.1 0.68 10.0 0.1 2.8 2 0 0 2 2 2 1 Helicase HerA, central domain AAA_5 PF07728.14 CAV17109.1 - 0.01 15.8 0.2 0.28 11.2 0.0 2.7 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) NTPase_1 PF03266.15 CAV17109.1 - 0.011 15.7 1.0 2.7 7.9 0.1 3.1 2 1 0 2 2 2 0 NTPase Zeta_toxin PF06414.12 CAV17109.1 - 0.014 14.7 0.7 4.9 6.4 0.0 2.5 2 0 0 2 2 2 0 Zeta toxin AAA_33 PF13671.6 CAV17109.1 - 0.014 15.6 0.3 3.8 7.7 0.2 2.8 2 1 0 2 2 2 0 AAA domain MeaB PF03308.16 CAV17109.1 - 0.014 14.4 0.4 0.68 8.9 0.1 2.3 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Sigma54_activat PF00158.26 CAV17109.1 - 0.016 14.9 0.4 2.3 7.9 0.0 2.6 3 0 0 3 3 2 0 Sigma-54 interaction domain G-alpha PF00503.20 CAV17109.1 - 0.019 14.2 0.3 0.083 12.0 0.0 2.0 2 2 0 2 2 2 0 G-protein alpha subunit AAA_24 PF13479.6 CAV17109.1 - 0.041 13.6 0.1 6.6 6.4 0.0 2.5 2 0 0 2 2 2 0 AAA domain NACHT PF05729.12 CAV17109.1 - 0.042 13.8 0.2 2.3 8.1 0.0 2.5 2 0 0 2 2 2 0 NACHT domain AAA_7 PF12775.7 CAV17109.1 - 0.093 12.2 0.1 11 5.5 0.0 2.3 2 0 0 2 2 2 0 P-loop containing dynein motor region Dynamin_N PF00350.23 CAV17109.1 - 0.14 12.2 1.0 8.1 6.5 0.9 2.6 2 0 0 2 2 2 0 Dynamin family AIG1 PF04548.16 CAV17109.1 - 0.21 10.9 1.1 1.8 7.8 0.1 2.4 2 0 0 2 2 2 0 AIG1 family CoaE PF01121.20 CAV17109.1 - 0.38 10.4 2.0 15 5.2 0.1 2.4 2 0 0 2 2 2 0 Dephospho-CoA kinase ATPase PF06745.13 CAV17109.1 - 0.42 9.9 1.8 10 5.4 0.1 2.8 3 0 0 3 3 2 0 KaiC SBP_bac_5 PF00496.22 CAV17110.1 - 7.9e-85 285.1 4.3 1e-84 284.7 4.3 1.1 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 5 Middle NTP_transf_5 PF14907.6 CAV17110.1 - 0.019 14.6 0.0 0.031 13.9 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised nucleotidyltransferase BPD_transp_1 PF00528.22 CAV17111.1 - 1.7e-36 125.7 15.0 1.7e-36 125.7 15.0 2.0 2 0 0 2 2 2 1 Binding-protein-dependent transport system inner membrane component Mid2 PF04478.12 CAV17111.1 - 0.011 15.5 0.1 0.023 14.5 0.1 1.4 1 0 0 1 1 1 0 Mid2 like cell wall stress sensor BPD_transp_1 PF00528.22 CAV17112.1 - 2.9e-29 102.1 12.9 2.9e-29 102.1 12.9 1.8 2 0 0 2 2 2 1 Binding-protein-dependent transport system inner membrane component OppC_N PF12911.7 CAV17112.1 - 5.9e-10 39.0 1.8 5.9e-10 39.0 1.8 3.6 3 2 0 3 3 3 1 N-terminal TM domain of oligopeptide transport permease C DUF4713 PF15831.5 CAV17112.1 - 6.9 7.2 6.3 2.1 8.8 0.2 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4713) SPOR PF05036.13 CAV17113.1 - 1.1e-10 41.7 0.0 2.6e-10 40.5 0.0 1.6 1 0 0 1 1 1 1 Sporulation related domain NQR2_RnfD_RnfE PF03116.15 CAV17114.1 - 2.9e-104 348.6 23.0 3.8e-104 348.2 23.0 1.1 1 0 0 1 1 1 1 NQR2, RnfD, RnfE family LPAM_1 PF08139.12 CAV17116.1 - 0.17 12.4 2.8 0.46 11.1 2.8 1.8 1 0 0 1 1 1 0 Prokaryotic membrane lipoprotein lipid attachment site LPAM_2 PF13627.6 CAV17116.1 - 3.8 7.5 4.2 7 6.6 4.2 1.5 1 0 0 1 1 1 0 Prokaryotic lipoprotein-attachment site Pyr_redox_2 PF07992.14 CAV17117.1 - 1.8e-69 234.2 2.0 1.8e-69 234.2 2.0 1.9 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.22 CAV17117.1 - 6.1e-33 113.4 1.3 6.1e-33 113.4 1.3 2.9 4 0 0 4 4 4 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.27 CAV17117.1 - 4e-20 72.1 1.3 2e-17 63.5 0.0 2.5 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 CAV17117.1 - 9.4e-20 71.1 6.3 2.5e-18 66.4 0.1 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 CAV17117.1 - 5.9e-08 31.8 2.3 0.03 13.0 1.1 4.0 3 1 1 4 4 4 2 HI0933-like protein GIDA PF01134.22 CAV17117.1 - 1.6e-06 27.5 1.3 3e-05 23.3 0.3 2.5 2 0 0 2 2 2 1 Glucose inhibited division protein A FAD_oxidored PF12831.7 CAV17117.1 - 2e-05 24.2 2.3 7e-05 22.3 1.5 2.0 2 0 0 2 2 2 1 FAD dependent oxidoreductase K_oxygenase PF13434.6 CAV17117.1 - 4.3e-05 22.8 0.0 0.00011 21.4 0.0 1.6 1 1 0 1 1 1 1 L-lysine 6-monooxygenase (NADPH-requiring) FAD_binding_2 PF00890.24 CAV17117.1 - 0.0004 19.6 5.6 0.032 13.3 2.2 2.4 2 0 0 2 2 2 2 FAD binding domain 3HCDH_N PF02737.18 CAV17117.1 - 0.0022 17.9 2.0 0.054 13.4 0.0 2.4 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_binding_8 PF13450.6 CAV17117.1 - 0.0034 17.6 0.5 0.0034 17.6 0.5 2.4 3 0 0 3 3 3 1 NAD(P)-binding Rossmann-like domain AlaDh_PNT_C PF01262.21 CAV17117.1 - 0.0047 16.2 0.6 1.3 8.3 0.0 2.4 2 0 0 2 2 2 2 Alanine dehydrogenase/PNT, C-terminal domain Amino_oxidase PF01593.24 CAV17117.1 - 0.0073 15.6 0.8 0.17 11.1 0.0 2.7 3 0 0 3 3 3 1 Flavin containing amine oxidoreductase 2-Hacid_dh_C PF02826.19 CAV17117.1 - 0.039 13.3 2.3 0.34 10.3 0.0 2.6 3 0 0 3 3 3 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain DAO PF01266.24 CAV17117.1 - 0.76 9.3 6.8 0.54 9.8 2.0 2.4 2 0 0 2 2 2 0 FAD dependent oxidoreductase DUF4920 PF16267.5 CAV17117.1 - 2.2 8.3 4.1 1.7 8.7 0.2 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF4920) RsmJ PF04378.13 CAV17118.1 - 8.1e-115 382.2 0.0 9.5e-115 382.0 0.0 1.0 1 0 0 1 1 1 1 Ribosomal RNA large subunit methyltransferase D, RlmJ Cons_hypoth95 PF03602.15 CAV17118.1 - 0.00045 19.9 0.0 0.0041 16.8 0.0 2.1 2 0 0 2 2 2 1 Conserved hypothetical protein 95 N6-adenineMlase PF10237.9 CAV17118.1 - 0.19 11.5 0.0 1.8 8.4 0.0 2.2 1 1 0 2 2 2 0 Probable N6-adenine methyltransferase Peptidase_M3 PF01432.20 CAV17119.1 - 1.6e-163 545.2 0.0 2e-163 544.9 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M3 Transglut_core2 PF13369.6 CAV17119.1 - 0.053 13.1 0.0 0.14 11.7 0.0 1.6 1 0 0 1 1 1 0 Transglutaminase-like superfamily Peptidase_M91 PF14891.6 CAV17119.1 - 0.12 12.6 0.0 11 6.3 0.0 2.4 2 0 0 2 2 2 0 Effector protein AsnC_trans_reg PF01037.21 CAV17120.1 - 7.7e-17 61.0 0.4 1.5e-16 60.2 0.1 1.6 2 0 0 2 2 2 1 Lrp/AsnC ligand binding domain HTH_AsnC-type PF13404.6 CAV17120.1 - 1.5e-14 53.6 0.1 2.5e-14 52.8 0.1 1.4 1 0 0 1 1 1 1 AsnC-type helix-turn-helix domain HTH_24 PF13412.6 CAV17120.1 - 3.6e-12 45.6 0.0 6.1e-12 44.9 0.0 1.4 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding HTH_20 PF12840.7 CAV17120.1 - 7.3e-06 26.0 0.1 1.2e-05 25.2 0.1 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_11 PF08279.12 CAV17120.1 - 0.001 19.0 0.0 0.0025 17.7 0.0 1.7 1 0 0 1 1 1 1 HTH domain MarR_2 PF12802.7 CAV17120.1 - 0.017 15.0 0.0 0.027 14.3 0.0 1.4 1 0 0 1 1 1 0 MarR family Sigma70_r4_2 PF08281.12 CAV17120.1 - 0.025 14.2 0.0 0.074 12.7 0.0 1.9 2 0 0 2 2 2 0 Sigma-70, region 4 MarR PF01047.22 CAV17120.1 - 0.085 12.8 0.1 0.19 11.7 0.1 1.6 1 0 0 1 1 1 0 MarR family DUF4080 PF13311.6 CAV17120.1 - 0.13 12.5 0.1 0.25 11.5 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4080) EAL PF00563.20 CAV17121.1 - 2e-55 187.9 0.0 3.6e-55 187.1 0.0 1.5 1 0 0 1 1 1 1 EAL domain GGDEF PF00990.21 CAV17121.1 - 3.9e-33 114.5 0.4 3.9e-33 114.5 0.4 1.8 2 0 0 2 2 2 1 Diguanylate cyclase, GGDEF domain PAS_9 PF13426.7 CAV17121.1 - 3e-13 49.9 0.0 2.6e-09 37.3 0.0 2.8 2 0 0 2 2 2 2 PAS domain PAS_4 PF08448.10 CAV17121.1 - 8.8e-12 45.3 1.0 1.6e-06 28.3 0.1 3.3 3 0 0 3 3 3 2 PAS fold PAS PF00989.25 CAV17121.1 - 1.2e-06 28.5 0.1 4.7e-06 26.6 0.0 2.1 2 0 0 2 2 2 1 PAS fold PAS_8 PF13188.7 CAV17121.1 - 0.00024 21.0 0.1 0.0024 17.8 0.0 2.5 2 0 0 2 2 2 1 PAS domain Toprim PF01751.22 CAV17121.1 - 0.00036 20.7 0.0 0.0011 19.1 0.0 1.8 1 0 0 1 1 1 1 Toprim domain PAS_3 PF08447.12 CAV17121.1 - 0.001 19.3 0.3 0.011 16.0 0.0 2.7 2 0 0 2 2 2 1 PAS fold ABC_sub_bind PF04392.12 CAV17121.1 - 0.035 13.4 0.0 0.087 12.1 0.0 1.6 1 0 0 1 1 1 0 ABC transporter substrate binding protein IF2_N PF04760.15 CAV17121.1 - 0.044 13.6 0.0 0.18 11.6 0.0 2.1 1 0 0 1 1 1 0 Translation initiation factor IF-2, N-terminal region DUF915 PF06028.11 CAV17121.1 - 0.058 12.7 0.0 0.11 11.8 0.0 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF915) SAM_MT PF04445.13 CAV17122.1 - 3.9e-107 356.9 0.0 4.5e-107 356.7 0.0 1.0 1 0 0 1 1 1 1 Putative SAM-dependent methyltransferase DUF3450 PF11932.8 CAV17123.1 - 0.0058 16.0 6.2 0.0078 15.5 6.2 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3450) IZUMO PF15005.6 CAV17123.1 - 0.014 15.9 1.9 0.026 15.0 1.9 1.5 1 0 0 1 1 1 0 Izumo sperm-egg fusion, Ig domain-associated DUF1682 PF07946.14 CAV17123.1 - 0.016 14.4 8.3 0.021 14.1 8.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) AAA_11 PF13086.6 CAV17123.1 - 0.023 14.5 4.5 0.027 14.3 4.5 1.1 1 0 0 1 1 1 0 AAA domain DUF4778 PF16008.5 CAV17123.1 - 0.064 13.3 4.1 0.082 13.0 4.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4778) UPF0449 PF15136.6 CAV17123.1 - 0.34 11.4 7.2 0.62 10.6 6.5 1.7 1 1 1 2 2 2 0 Uncharacterised protein family UPF0449 EamA PF00892.20 CAV17124.1 - 2.9e-12 46.9 35.3 9.2e-07 29.1 7.5 2.1 2 0 0 2 2 2 2 EamA-like transporter family Usp PF00582.26 CAV17125.1 - 2.1e-22 80.2 0.0 2.4e-22 80.0 0.0 1.0 1 0 0 1 1 1 1 Universal stress protein family TPP_enzyme_M PF00205.22 CAV17125.1 - 0.052 13.3 0.0 2.1 8.1 0.0 2.2 1 1 0 2 2 2 0 Thiamine pyrophosphate enzyme, central domain Ferritin PF00210.24 CAV17126.1 - 1.5e-39 135.2 3.8 1.8e-39 134.9 3.8 1.1 1 0 0 1 1 1 1 Ferritin-like domain Rubrerythrin PF02915.17 CAV17126.1 - 0.032 14.6 3.0 0.15 12.5 2.9 1.9 1 1 0 1 1 1 0 Rubrerythrin Tom37 PF10568.9 CAV17126.1 - 0.11 12.9 0.0 0.18 12.1 0.0 1.4 1 0 0 1 1 1 0 Outer mitochondrial membrane transport complex protein UspB PF10625.9 CAV17127.1 - 5e-53 177.6 1.5 5.5e-53 177.5 1.5 1.0 1 0 0 1 1 1 1 Universal stress protein B (UspB) HI0933_like PF03486.14 CAV17129.1 - 6.5e-160 532.3 0.0 7.3e-160 532.1 0.0 1.0 1 0 0 1 1 1 1 HI0933-like protein FAD_binding_2 PF00890.24 CAV17129.1 - 4.3e-15 55.7 0.3 8.3e-10 38.3 0.5 3.0 3 0 0 3 3 3 2 FAD binding domain Pyr_redox_3 PF13738.6 CAV17129.1 - 1.2e-10 41.2 0.7 0.0002 20.7 0.0 2.6 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 CAV17129.1 - 4.5e-10 39.2 0.2 4.7e-09 35.9 0.1 2.3 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 CAV17129.1 - 5.3e-09 36.1 1.3 0.00034 20.3 1.3 2.2 1 1 1 2 2 2 2 FAD dependent oxidoreductase GIDA PF01134.22 CAV17129.1 - 2e-08 33.8 1.5 0.001 18.2 0.9 2.7 3 1 0 3 3 3 2 Glucose inhibited division protein A FAD_oxidored PF12831.7 CAV17129.1 - 9.8e-08 31.8 0.0 1.5e-07 31.1 0.0 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 CAV17129.1 - 3.5e-07 30.3 0.1 9e-07 29.0 0.1 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.27 CAV17129.1 - 4e-05 24.1 0.7 0.0045 17.5 0.3 2.7 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 CAV17129.1 - 0.00018 20.8 0.4 0.00081 18.7 0.1 2.1 3 0 0 3 3 3 1 FAD binding domain Lycopene_cycl PF05834.12 CAV17129.1 - 0.00023 20.3 1.0 0.0017 17.5 0.6 1.9 2 0 0 2 2 2 1 Lycopene cyclase protein NAD_binding_9 PF13454.6 CAV17129.1 - 0.0005 20.1 0.0 0.0013 18.7 0.0 1.7 1 1 0 1 1 1 1 FAD-NAD(P)-binding Thi4 PF01946.17 CAV17129.1 - 0.0016 17.7 0.1 0.0032 16.7 0.1 1.5 1 0 0 1 1 1 1 Thi4 family DUF2124 PF09897.9 CAV17129.1 - 0.0043 17.0 0.0 0.013 15.4 0.0 1.8 2 0 0 2 2 2 1 Uncharacterized protein conserved in archaea (DUF2124) AlaDh_PNT_C PF01262.21 CAV17129.1 - 0.025 13.9 0.0 0.044 13.1 0.0 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Amino_oxidase PF01593.24 CAV17129.1 - 0.028 13.7 0.3 0.13 11.6 0.0 2.1 2 1 0 2 2 2 0 Flavin containing amine oxidoreductase UDPG_MGDP_dh_N PF03721.14 CAV17129.1 - 0.18 11.4 0.2 0.42 10.2 0.2 1.6 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain EamA PF00892.20 CAV17131.1 - 9.9e-35 119.7 40.6 3.2e-18 66.2 15.6 2.0 2 0 0 2 2 2 2 EamA-like transporter family EmrE PF13536.6 CAV17131.1 - 4.9e-05 23.0 19.4 0.00012 21.8 19.2 1.7 1 1 0 1 1 1 1 Putative multidrug resistance efflux transporter RmuC PF02646.16 CAV17132.1 - 5.5e-107 357.2 6.4 5.5e-107 357.2 6.4 3.0 2 1 1 3 3 3 1 RmuC family DUF1043 PF06295.12 CAV17132.1 - 0.0068 16.4 5.6 0.0068 16.4 5.6 4.5 2 1 3 5 5 5 2 Protein of unknown function (DUF1043) SRA1 PF07304.11 CAV17132.1 - 0.058 13.2 1.2 0.2 11.4 1.2 1.9 1 0 0 1 1 1 0 Steroid receptor RNA activator (SRA1) LapA_dom PF06305.11 CAV17132.1 - 0.85 9.5 4.9 13 5.7 4.9 2.9 1 1 0 1 1 1 0 Lipopolysaccharide assembly protein A domain Ubie_methyltran PF01209.18 CAV17133.1 - 8.5e-102 339.4 0.0 9.8e-102 339.2 0.0 1.0 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_25 PF13649.6 CAV17133.1 - 1.1e-24 87.0 0.0 2.2e-24 86.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CAV17133.1 - 1.5e-23 83.2 0.0 2.9e-23 82.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CAV17133.1 - 1.2e-19 70.6 0.0 2.1e-19 69.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CAV17133.1 - 4.7e-18 65.6 0.0 7.5e-18 64.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CAV17133.1 - 3.2e-15 56.7 0.0 5.6e-15 55.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 CAV17133.1 - 1.5e-09 38.0 0.0 2e-09 37.6 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) MTS PF05175.14 CAV17133.1 - 6.3e-05 22.6 0.0 0.00011 21.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain GCD14 PF08704.10 CAV17133.1 - 8.9e-05 22.3 0.0 0.00037 20.2 0.0 1.7 1 1 1 2 2 2 1 tRNA methyltransferase complex GCD14 subunit MetW PF07021.12 CAV17133.1 - 0.00027 20.6 0.0 0.00049 19.7 0.0 1.3 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW UPF0020 PF01170.18 CAV17133.1 - 0.0012 18.6 0.1 0.01 15.6 0.0 2.5 2 1 1 3 3 3 1 Putative RNA methylase family UPF0020 Rsm22 PF09243.10 CAV17133.1 - 0.0023 17.3 0.0 0.003 16.9 0.0 1.3 1 0 0 1 1 1 1 Mitochondrial small ribosomal subunit Rsm22 Methyltransf_2 PF00891.18 CAV17133.1 - 0.0053 16.1 0.0 0.0072 15.6 0.0 1.3 1 0 0 1 1 1 1 O-methyltransferase domain RrnaAD PF00398.20 CAV17133.1 - 0.0077 15.3 0.0 0.012 14.7 0.0 1.3 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Methyltransf_8 PF05148.15 CAV17133.1 - 0.011 15.6 0.0 0.053 13.4 0.0 2.0 2 1 0 2 2 2 0 Hypothetical methyltransferase Methyltransf_29 PF03141.16 CAV17133.1 - 0.016 13.8 0.0 0.026 13.1 0.0 1.3 1 0 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase NNMT_PNMT_TEMT PF01234.17 CAV17133.1 - 0.064 12.4 0.0 0.15 11.3 0.0 1.7 2 0 0 2 2 2 0 NNMT/PNMT/TEMT family Methyltr_RsmB-F PF01189.17 CAV17133.1 - 0.09 12.4 0.0 1.9 8.1 0.0 2.2 2 0 0 2 2 2 0 16S rRNA methyltransferase RsmB/F DREV PF05219.12 CAV17133.1 - 0.11 11.6 0.0 0.17 11.0 0.0 1.3 1 0 0 1 1 1 0 DREV methyltransferase SCP2 PF02036.17 CAV17134.1 - 1.1e-22 80.4 0.1 2.2e-22 79.4 0.1 1.5 1 0 0 1 1 1 1 SCP-2 sterol transfer family ABC1 PF03109.16 CAV17135.1 - 3e-35 121.0 0.0 5e-35 120.3 0.0 1.4 1 0 0 1 1 1 1 ABC1 family APH PF01636.23 CAV17135.1 - 0.096 12.6 1.9 1.2 9.0 0.1 2.8 1 1 0 2 2 2 0 Phosphotransferase enzyme family MttA_Hcf106 PF02416.16 CAV17136.1 - 3.3e-14 51.9 1.4 4.6e-14 51.5 1.4 1.4 1 1 0 1 1 1 1 mttA/Hcf106 family DUF1980 PF09323.10 CAV17136.1 - 0.022 14.7 0.0 0.025 14.5 0.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) DUF4834 PF16118.5 CAV17136.1 - 0.045 14.7 0.0 0.059 14.3 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) MttA_Hcf106 PF02416.16 CAV17137.1 - 9.4e-05 21.7 3.1 0.00015 21.0 3.1 1.6 1 1 0 1 1 1 1 mttA/Hcf106 family Glycogen_syn PF05693.13 CAV17137.1 - 0.18 10.3 0.2 0.21 10.1 0.2 1.0 1 0 0 1 1 1 0 Glycogen synthase SMYLE_N PF18615.1 CAV17137.1 - 0.22 11.1 4.2 0.26 10.8 4.2 1.0 1 0 0 1 1 1 0 Short myomegalin-like EB1 binding proteins, N-terminal domain TatC PF00902.18 CAV17138.1 - 6.9e-66 222.0 21.8 6.9e-66 222.0 21.8 1.3 2 0 0 2 2 2 1 Sec-independent protein translocase protein (TatC) TatD_DNase PF01026.21 CAV17139.1 - 5.1e-66 222.6 0.0 5.8e-66 222.5 0.0 1.0 1 0 0 1 1 1 1 TatD related DNase Amidohydro_1 PF01979.20 CAV17139.1 - 0.0065 15.8 0.0 0.019 14.3 0.0 1.7 1 1 0 1 1 1 1 Amidohydrolase family GnsAB_toxin PF08178.11 CAV17139.1 - 0.064 13.2 0.1 0.16 11.9 0.0 1.7 2 0 0 2 2 2 0 GnsA/GnsB toxin of bacterial toxin-antitoxin system ALAD PF00490.21 CAV17140.1 - 4.3e-137 456.5 0.3 4.9e-137 456.3 0.3 1.0 1 0 0 1 1 1 1 Delta-aminolevulinic acid dehydratase Acetyltransf_1 PF00583.25 CAV17141.1 - 9.9e-06 25.8 0.0 1.4e-05 25.3 0.0 1.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 CAV17141.1 - 0.013 15.4 0.1 0.016 15.2 0.1 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 CAV17141.1 - 0.047 14.1 0.0 0.069 13.6 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain DNA_pol_A PF00476.20 CAV17142.1 - 4e-156 519.8 0.4 5.9e-156 519.2 0.4 1.2 1 0 0 1 1 1 1 DNA polymerase family A 5_3_exonuc_N PF02739.16 CAV17142.1 - 5.3e-55 185.7 0.0 1.6e-54 184.1 0.0 1.8 2 0 0 2 2 2 1 5'-3' exonuclease, N-terminal resolvase-like domain DNA_pol_A_exo1 PF01612.20 CAV17142.1 - 4.9e-40 137.1 0.3 9.4e-40 136.2 0.3 1.5 1 0 0 1 1 1 1 3'-5' exonuclease 5_3_exonuc PF01367.20 CAV17142.1 - 3.4e-29 101.3 0.2 1.2e-28 99.6 0.2 2.0 1 0 0 1 1 1 1 5'-3' exonuclease, C-terminal SAM fold HHH_5 PF14520.6 CAV17142.1 - 0.0013 19.3 0.5 0.0095 16.5 0.1 2.8 3 0 0 3 3 3 1 Helix-hairpin-helix domain HHH_2 PF12826.7 CAV17142.1 - 0.08 13.1 0.1 0.52 10.4 0.0 2.4 2 0 0 2 2 2 0 Helix-hairpin-helix motif DUF1906 PF08924.11 CAV17142.1 - 0.096 12.8 0.1 0.21 11.7 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF1906) TrbL PF04610.14 CAV17143.1 - 0.00011 22.0 1.2 0.00022 21.1 1.2 1.5 1 0 0 1 1 1 1 TrbL/VirB6 plasmid conjugal transfer protein TEX13 PF15186.6 CAV17143.1 - 0.0006 19.5 0.2 0.0015 18.3 0.0 1.8 2 0 0 2 2 2 1 Testis-expressed sequence 13 protein family GP41 PF00517.17 CAV17143.1 - 0.00062 19.7 6.2 0.00082 19.3 5.6 1.4 1 1 0 1 1 1 1 Retroviral envelope protein YkyA PF10368.9 CAV17143.1 - 0.013 15.2 7.4 0.021 14.5 1.9 2.1 2 0 0 2 2 2 0 Putative cell-wall binding lipoprotein SesA PF17107.5 CAV17143.1 - 0.016 15.4 4.9 0.022 14.9 1.0 2.2 2 0 0 2 2 2 0 N-terminal domain on NACHT_NTPase and P-loop NTPases DUF745 PF05335.13 CAV17143.1 - 0.017 14.9 9.5 0.029 14.1 3.4 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF745) Laminin_II PF06009.12 CAV17143.1 - 0.034 14.2 7.6 1.4 8.9 2.6 2.2 2 0 0 2 2 2 0 Laminin Domain II DUF948 PF06103.11 CAV17143.1 - 0.038 14.3 16.7 0.067 13.4 5.6 2.9 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) T2SSM PF04612.12 CAV17143.1 - 0.094 12.8 0.3 0.094 12.8 0.3 2.2 2 0 0 2 2 2 0 Type II secretion system (T2SS), protein M DUF4389 PF14333.6 CAV17143.1 - 0.17 11.8 1.2 0.34 10.9 1.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4389) CwsA PF10814.8 CAV17143.1 - 0.19 11.9 0.8 0.42 10.8 0.3 1.9 2 0 0 2 2 2 0 Cell wall synthesis protein CwsA Fib_alpha PF08702.10 CAV17143.1 - 0.2 11.9 9.4 0.27 11.4 2.4 2.1 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family Shisa PF13908.6 CAV17143.1 - 0.21 11.8 3.1 0.31 11.3 2.9 1.4 1 1 0 1 1 1 0 Wnt and FGF inhibitory regulator DUF148 PF02520.17 CAV17143.1 - 0.39 10.9 10.3 0.45 10.6 3.7 2.7 2 1 0 2 2 2 0 Domain of unknown function DUF148 Orf78 PF06024.12 CAV17143.1 - 1.1 9.6 7.8 1.7 9.0 6.9 1.9 1 1 0 1 1 1 0 Orf78 (ac78) DUF4446 PF14584.6 CAV17143.1 - 1.8 8.5 8.2 1.3 9.0 1.7 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF4446) AI-2E_transport PF01594.16 CAV17143.1 - 2 7.5 13.7 0.06 12.5 4.1 2.1 1 1 1 2 2 2 0 AI-2E family transporter DUF1542 PF07564.11 CAV17143.1 - 3.1 7.9 11.4 0.074 13.2 2.7 2.6 2 2 1 3 3 3 0 Domain of Unknown Function (DUF1542) YjcZ PF13990.6 CAV17143.1 - 8.5 5.7 8.9 9.9 5.5 2.1 2.1 1 1 1 2 2 2 0 YjcZ-like protein MMR_HSR1 PF01926.23 CAV17144.1 - 8.6e-20 70.9 0.0 1.4e-19 70.2 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 CAV17144.1 - 1.9e-07 31.2 0.0 0.0013 18.7 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase FeoB_N PF02421.18 CAV17144.1 - 1e-05 25.1 0.0 1.4e-05 24.6 0.0 1.3 1 0 0 1 1 1 1 Ferrous iron transport protein B Dynamin_N PF00350.23 CAV17144.1 - 0.015 15.4 0.1 1 9.4 0.1 2.3 1 1 1 2 2 2 0 Dynamin family GTP_EFTU PF00009.27 CAV17144.1 - 0.024 14.2 0.1 0.31 10.6 0.0 2.2 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain SRPRB PF09439.10 CAV17144.1 - 0.03 13.7 0.0 0.057 12.8 0.0 1.4 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit Cytochrom_C PF00034.21 CAV17145.1 - 1.3e-21 77.5 4.0 3.1e-10 41.1 0.3 2.5 2 1 0 2 2 2 2 Cytochrome c Cytochrome_CBB3 PF13442.6 CAV17145.1 - 1.2e-12 47.9 3.9 3.4e-05 24.1 0.0 2.7 2 1 0 2 2 2 2 Cytochrome C oxidase, cbb3-type, subunit III Cytochrom_NNT PF03264.14 CAV17145.1 - 0.0013 18.5 0.2 0.3 10.8 0.1 2.1 2 0 0 2 2 2 2 NapC/NirT cytochrome c family, N-terminal region Cytochrome_C7 PF14522.6 CAV17145.1 - 0.0045 17.0 0.3 2.3 8.3 0.1 2.3 2 0 0 2 2 2 2 Cytochrome c7 and related cytochrome c DUF3365 PF11845.8 CAV17145.1 - 0.006 16.9 0.8 0.55 10.5 0.1 2.4 2 1 0 2 2 2 1 Protein of unknown function (DUF3365) DUF1924 PF09086.11 CAV17145.1 - 0.0061 16.9 0.5 3.6 8.0 0.0 2.5 2 0 0 2 2 2 2 Domain of unknown function (DUF1924) Paired_CXXCH_1 PF09699.10 CAV17145.1 - 0.011 15.5 0.6 4.1 7.2 0.1 2.5 2 0 0 2 2 2 0 Doubled CXXCH motif (Paired_CXXCH_1) DUF4119 PF13494.6 CAV17145.1 - 0.041 14.0 0.2 0.095 12.8 0.0 1.6 2 0 0 2 2 1 0 Domain of unknown function, B. Theta Gene description (DUF4119) zf-RanBP PF00641.18 CAV17145.1 - 0.054 12.8 0.9 5 6.5 0.1 2.2 2 0 0 2 2 2 0 Zn-finger in Ran binding protein and others Cytochrom_c3_2 PF14537.6 CAV17145.1 - 0.067 13.7 0.3 4.5 7.8 0.2 2.3 2 0 0 2 2 2 0 Cytochrome c3 PSCyt1 PF07635.11 CAV17145.1 - 0.11 13.1 2.4 12 6.6 0.2 2.7 2 0 0 2 2 2 0 Planctomycete cytochrome C Cytochrome_P460 PF16694.5 CAV17145.1 - 0.18 12.2 0.1 22 5.4 0.1 2.3 2 0 0 2 2 2 0 Cytochrome P460 Methyltransf_23 PF13489.6 CAV17146.1 - 5.6e-17 62.1 0.0 9.8e-17 61.3 0.0 1.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CAV17146.1 - 1e-05 26.2 0.1 0.011 16.4 0.0 3.1 2 2 2 4 4 4 1 Methyltransferase domain Methyltransf_31 PF13847.6 CAV17146.1 - 2.4e-05 24.2 0.0 0.035 13.9 0.0 2.2 1 1 1 2 2 2 2 Methyltransferase domain Methyltransf_11 PF08241.12 CAV17146.1 - 4.3e-05 24.1 0.0 0.0054 17.4 0.0 2.8 2 1 1 3 3 2 1 Methyltransferase domain A2L_zn_ribbon PF08792.10 CAV17146.1 - 0.0038 16.9 1.6 0.0074 16.0 1.6 1.5 1 0 0 1 1 1 1 A2L zinc ribbon domain DpnI PF06044.12 CAV17146.1 - 0.0047 16.6 0.2 0.0076 15.9 0.2 1.3 1 0 0 1 1 1 1 Dam-replacing family Elf1 PF05129.13 CAV17146.1 - 0.0049 16.9 0.6 0.011 15.7 0.6 1.6 1 0 0 1 1 1 1 Transcription elongation factor Elf1 like Methyltransf_25 PF13649.6 CAV17146.1 - 0.0081 16.8 0.1 7.9 7.3 0.0 2.9 2 1 1 3 3 3 1 Methyltransferase domain Lar_restr_allev PF14354.6 CAV17146.1 - 0.017 15.5 1.1 0.036 14.5 1.1 1.5 1 0 0 1 1 1 0 Restriction alleviation protein Lar zf-CHY PF05495.12 CAV17146.1 - 0.042 14.3 2.9 0.068 13.7 2.9 1.4 1 0 0 1 1 1 0 CHY zinc finger zf-piccolo PF05715.13 CAV17146.1 - 0.088 13.0 0.8 0.17 12.1 0.8 1.4 1 0 0 1 1 1 0 Piccolo Zn-finger Zn_Tnp_IS1595 PF12760.7 CAV17146.1 - 0.11 12.5 3.7 0.23 11.5 3.7 1.4 1 0 0 1 1 1 0 Transposase zinc-ribbon domain MTS PF05175.14 CAV17146.1 - 0.13 11.8 0.0 0.18 11.3 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase small domain TF_Zn_Ribbon PF08271.12 CAV17146.1 - 0.2 11.2 0.3 0.46 10.1 0.3 1.6 1 0 0 1 1 1 0 TFIIB zinc-binding YihI PF04220.12 CAV17147.1 - 1.3e-45 154.9 12.2 1.8e-45 154.5 12.2 1.1 1 0 0 1 1 1 1 Der GTPase activator (YihI) DUF2489 PF10675.9 CAV17148.1 - 1.2e-43 148.1 0.9 1.4e-43 147.9 0.9 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2489) DUF2681 PF10883.8 CAV17148.1 - 0.026 14.9 0.3 0.026 14.9 0.3 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2681) ZapD PF07072.11 CAV17148.1 - 0.17 11.6 3.5 0.082 12.7 0.9 1.7 2 0 0 2 2 2 0 Cell division protein RIC3 PF15361.6 CAV17148.1 - 0.21 12.0 1.4 7.3 7.0 0.8 2.0 2 0 0 2 2 2 0 Resistance to inhibitors of cholinesterase homologue 3 Radical_SAM PF04055.21 CAV17149.1 - 2.1e-19 70.5 0.2 3.5e-19 69.8 0.2 1.3 1 0 0 1 1 1 1 Radical SAM superfamily HemN_C PF06969.16 CAV17149.1 - 1.8e-10 40.7 1.3 5.2e-10 39.2 0.5 2.3 2 0 0 2 2 2 1 HemN C-terminal domain NAD_binding_1 PF00175.21 CAV17149.1 - 0.033 14.8 0.0 0.088 13.5 0.0 1.7 1 0 0 1 1 1 0 Oxidoreductase NAD-binding domain EAL PF00563.20 CAV17150.1 - 1.6e-71 240.6 0.1 3.2e-71 239.6 0.1 1.5 1 0 0 1 1 1 1 EAL domain GGDEF PF00990.21 CAV17150.1 - 1.4e-27 96.4 0.0 3e-27 95.3 0.0 1.6 1 0 0 1 1 1 1 Diguanylate cyclase, GGDEF domain dCache_1 PF02743.18 CAV17150.1 - 2.6e-19 70.0 2.4 2.6e-19 70.0 2.4 2.1 2 0 0 2 2 2 1 Cache domain HAMP PF00672.25 CAV17150.1 - 1.7e-07 31.5 0.0 8.4e-07 29.3 0.0 2.2 2 0 0 2 2 2 1 HAMP domain GAPES1 PF17155.4 CAV17150.1 - 0.0013 18.1 0.0 0.0026 17.1 0.0 1.4 1 0 0 1 1 1 1 Gammaproteobacterial periplasmic sensor domain Yip1 PF04893.17 CAV17150.1 - 0.036 13.8 0.2 0.31 10.7 0.0 2.1 2 0 0 2 2 2 0 Yip1 domain Sigma54_activat PF00158.26 CAV17151.1 - 8.2e-71 237.1 0.0 1.5e-70 236.3 0.0 1.4 1 0 0 1 1 1 1 Sigma-54 interaction domain Response_reg PF00072.24 CAV17151.1 - 1e-28 99.7 0.0 2.1e-28 98.7 0.0 1.6 1 0 0 1 1 1 1 Response regulator receiver domain Sigma54_activ_2 PF14532.6 CAV17151.1 - 7.3e-24 84.4 0.0 3.9e-23 82.1 0.0 2.1 1 1 0 1 1 1 1 Sigma-54 interaction domain HTH_8 PF02954.19 CAV17151.1 - 2.7e-18 65.4 0.1 6e-16 57.9 0.1 2.6 2 0 0 2 2 2 1 Bacterial regulatory protein, Fis family AAA_5 PF07728.14 CAV17151.1 - 1.5e-08 34.7 0.0 4.3e-08 33.3 0.0 1.8 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 CAV17151.1 - 1.6e-05 25.1 0.0 6.9e-05 23.0 0.0 2.0 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) HTH_30 PF13556.6 CAV17151.1 - 0.0023 17.7 0.9 0.33 10.8 0.1 2.9 2 1 0 2 2 2 1 PucR C-terminal helix-turn-helix domain Mg_chelatase PF01078.21 CAV17151.1 - 0.0053 16.2 0.1 0.67 9.3 0.0 2.3 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA PF00004.29 CAV17151.1 - 0.0058 17.0 0.0 0.017 15.5 0.0 1.9 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) LSDAT_prok PF18171.1 CAV17151.1 - 0.028 13.6 0.0 1.2 8.3 0.0 2.3 2 0 0 2 2 2 0 SLOG in TRPM, prokaryote ERAP1_C PF11838.8 CAV17151.1 - 0.044 13.3 0.1 0.081 12.4 0.1 1.4 1 0 0 1 1 1 0 ERAP1-like C-terminal domain OKR_DC_1_N PF03709.15 CAV17151.1 - 0.06 13.6 0.0 0.12 12.6 0.0 1.5 1 0 0 1 1 1 0 Orn/Lys/Arg decarboxylase, N-terminal domain AAA_16 PF13191.6 CAV17151.1 - 0.079 13.3 0.0 0.21 12.0 0.0 1.8 1 0 0 1 1 1 0 AAA ATPase domain RWP-RK PF02042.15 CAV17151.1 - 0.14 12.1 0.5 13 5.8 0.0 2.5 2 1 0 2 2 2 0 RWP-RK domain HTH_3 PF01381.22 CAV17151.1 - 0.15 12.1 0.0 9.8 6.3 0.0 2.6 2 0 0 2 2 2 0 Helix-turn-helix AAA_7 PF12775.7 CAV17151.1 - 0.16 11.5 0.0 0.29 10.6 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region HATPase_c PF02518.26 CAV17152.1 - 4.9e-19 68.9 0.1 2.3e-18 66.7 0.0 2.1 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 CAV17152.1 - 4.5e-14 52.2 1.4 4.1e-13 49.1 0.1 3.0 2 1 1 3 3 3 1 His Kinase A (phospho-acceptor) domain PAS PF00989.25 CAV17152.1 - 4.8e-14 52.3 0.2 1.3e-12 47.7 0.0 2.9 3 0 0 3 3 3 1 PAS fold PAS_9 PF13426.7 CAV17152.1 - 7.1e-06 26.2 0.0 2.8e-05 24.3 0.0 1.9 2 0 0 2 2 2 1 PAS domain PAS_4 PF08448.10 CAV17152.1 - 1.5e-05 25.2 0.1 4.2e-05 23.7 0.0 1.9 2 0 0 2 2 2 1 PAS fold PAS_10 PF13596.6 CAV17152.1 - 0.0052 17.4 0.0 0.035 14.7 0.0 2.2 2 0 0 2 2 2 1 PAS domain PAS_8 PF13188.7 CAV17152.1 - 0.027 14.5 0.1 0.2 11.7 0.0 2.3 2 0 0 2 2 2 0 PAS domain HATPase_c_2 PF13581.6 CAV17152.1 - 0.11 12.4 0.0 0.2 11.6 0.0 1.4 1 0 0 1 1 1 0 Histidine kinase-like ATPase domain DUF4124 PF13511.6 CAV17153.1 - 2e-10 40.9 8.7 1.6e-09 37.9 8.7 2.2 1 1 0 1 1 1 1 Domain of unknown function (DUF4124) Gln-synt_C PF00120.24 CAV17154.1 - 1.1e-136 455.4 0.0 1.4e-136 455.0 0.0 1.1 1 0 0 1 1 1 1 Glutamine synthetase, catalytic domain Gln-synt_N PF03951.19 CAV17154.1 - 3.1e-30 103.7 0.2 6e-30 102.8 0.2 1.5 1 0 0 1 1 1 1 Glutamine synthetase, beta-Grasp domain GTP_EFTU PF00009.27 CAV17156.1 - 1.9e-57 193.9 0.1 2.9e-57 193.3 0.1 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_C PF00679.24 CAV17156.1 - 2.3e-22 78.8 0.1 7.1e-22 77.3 0.1 1.8 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 CAV17156.1 - 4.6e-10 39.8 2.9 4.6e-10 39.8 2.9 2.7 3 0 0 3 3 3 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 CAV17156.1 - 1.1e-06 28.8 0.1 2.4e-06 27.6 0.1 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase EFG_II PF14492.6 CAV17156.1 - 0.00051 20.1 0.3 0.0015 18.6 0.1 1.9 2 0 0 2 2 2 1 Elongation Factor G, domain II Septin PF00735.18 CAV17156.1 - 0.00086 18.7 0.1 0.0014 18.0 0.1 1.2 1 0 0 1 1 1 1 Septin FeoB_N PF02421.18 CAV17156.1 - 0.016 14.7 0.2 0.29 10.6 0.0 3.0 3 1 0 3 3 3 0 Ferrous iron transport protein B SRPRB PF09439.10 CAV17156.1 - 0.029 13.8 0.1 0.11 11.9 0.1 2.0 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit Dynamin_N PF00350.23 CAV17156.1 - 0.097 12.7 0.0 2 8.4 0.0 2.3 1 1 1 2 2 2 0 Dynamin family AAA_28 PF13521.6 CAV17157.1 - 4.8e-36 124.5 0.0 5.4e-36 124.3 0.0 1.0 1 0 0 1 1 1 1 AAA domain MMR_HSR1 PF01926.23 CAV17157.1 - 7.7e-05 22.7 0.0 0.00014 21.9 0.0 1.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_18 PF13238.6 CAV17157.1 - 0.00018 22.0 0.0 0.00022 21.7 0.0 1.3 1 1 0 1 1 1 1 AAA domain ATP_bind_2 PF03668.15 CAV17157.1 - 0.0037 16.6 0.1 0.01 15.2 0.0 1.7 2 1 0 2 2 2 1 P-loop ATPase protein family AAA_19 PF13245.6 CAV17157.1 - 0.005 17.2 0.7 0.0088 16.4 0.7 1.4 1 0 0 1 1 1 1 AAA domain SRPRB PF09439.10 CAV17157.1 - 0.01 15.3 0.0 0.013 14.9 0.0 1.1 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit cobW PF02492.19 CAV17157.1 - 0.012 15.3 0.1 0.022 14.4 0.1 1.4 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain Viral_helicase1 PF01443.18 CAV17157.1 - 0.013 15.3 0.0 0.017 14.8 0.0 1.3 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase NTPase_1 PF03266.15 CAV17157.1 - 0.013 15.4 0.2 0.024 14.5 0.2 1.4 1 0 0 1 1 1 0 NTPase Zeta_toxin PF06414.12 CAV17157.1 - 0.014 14.7 0.4 0.04 13.2 0.1 1.9 2 0 0 2 2 2 0 Zeta toxin AAA_16 PF13191.6 CAV17157.1 - 0.014 15.7 0.0 0.018 15.4 0.0 1.2 1 0 0 1 1 1 0 AAA ATPase domain ABC_tran PF00005.27 CAV17157.1 - 0.018 15.5 0.2 0.032 14.7 0.2 1.7 1 1 0 1 1 1 0 ABC transporter AAA_29 PF13555.6 CAV17157.1 - 0.021 14.5 0.1 0.034 13.9 0.1 1.3 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_23 PF13476.6 CAV17157.1 - 0.027 15.0 2.1 0.03 14.8 1.3 1.4 1 1 0 1 1 1 0 AAA domain AAA_30 PF13604.6 CAV17157.1 - 0.028 14.1 0.3 0.05 13.3 0.3 1.3 1 0 0 1 1 1 0 AAA domain AAA_17 PF13207.6 CAV17157.1 - 0.031 14.7 0.2 0.048 14.1 0.2 1.6 1 1 0 1 1 1 0 AAA domain AAA_22 PF13401.6 CAV17157.1 - 0.032 14.5 0.2 0.053 13.8 0.2 1.5 1 1 0 1 1 1 0 AAA domain T2SSE PF00437.20 CAV17157.1 - 0.033 13.3 0.3 0.054 12.6 0.3 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA PF00004.29 CAV17157.1 - 0.046 14.1 0.1 0.07 13.6 0.1 1.6 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_24 PF13479.6 CAV17157.1 - 0.048 13.4 0.4 0.28 10.9 0.5 2.0 1 1 1 2 2 2 0 AAA domain FeoB_N PF02421.18 CAV17157.1 - 0.07 12.7 0.0 0.13 11.8 0.0 1.5 1 1 0 1 1 1 0 Ferrous iron transport protein B NACHT PF05729.12 CAV17157.1 - 0.074 13.0 0.8 0.33 10.9 0.2 2.2 3 0 0 3 3 3 0 NACHT domain RsgA_GTPase PF03193.16 CAV17157.1 - 0.09 12.7 0.0 0.3 11.0 0.0 1.9 2 0 0 2 2 2 0 RsgA GTPase DUF2075 PF09848.9 CAV17157.1 - 0.092 12.0 0.0 0.14 11.4 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) MeaB PF03308.16 CAV17157.1 - 0.11 11.5 0.2 0.18 10.7 0.2 1.3 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB IstB_IS21 PF01695.17 CAV17157.1 - 0.15 11.8 0.1 0.26 11.0 0.1 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein PduV-EutP PF10662.9 CAV17157.1 - 0.2 11.4 0.0 0.3 10.8 0.0 1.4 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation DUF2959 PF11172.8 CAV17158.1 - 2.2e-83 279.1 9.7 2.5e-83 278.9 9.7 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2959) Ferritin PF00210.24 CAV17158.1 - 0.001 19.0 1.3 0.001 19.0 1.3 1.6 2 0 0 2 2 2 1 Ferritin-like domain ApoO PF09769.9 CAV17158.1 - 0.01 15.8 1.2 0.96 9.4 0.0 2.7 2 1 1 3 3 3 0 Apolipoprotein O HWE_HK PF07536.14 CAV17158.1 - 0.019 15.6 1.2 1.5 9.6 0.0 2.8 1 1 1 2 2 2 0 HWE histidine kinase CdvA PF18822.1 CAV17158.1 - 0.078 12.8 6.4 0.85 9.5 0.1 3.2 2 2 1 3 3 3 0 CdvA-like coiled-coil domain DUF5082 PF16888.5 CAV17158.1 - 0.093 13.0 8.9 2.9 8.2 1.2 2.9 2 1 0 2 2 2 0 Domain of unknown function (DUF5082) DUF948 PF06103.11 CAV17158.1 - 0.17 12.2 3.4 16 5.8 0.2 3.2 2 2 0 2 2 2 0 Bacterial protein of unknown function (DUF948) ABC_tran_CTD PF16326.5 CAV17158.1 - 0.23 11.7 6.4 0.51 10.6 0.1 3.5 3 1 1 4 4 4 0 ABC transporter C-terminal domain DUF848 PF05852.11 CAV17158.1 - 0.89 9.7 5.3 9.6 6.3 0.5 2.8 1 1 2 3 3 3 0 Gammaherpesvirus protein of unknown function (DUF848) HIP1_clath_bdg PF16515.5 CAV17158.1 - 0.92 10.2 7.6 1.4 9.6 0.5 2.5 2 1 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 CorA PF01544.18 CAV17158.1 - 0.98 8.7 5.0 1.7 7.9 0.2 2.3 1 1 1 2 2 2 0 CorA-like Mg2+ transporter protein WXG100 PF06013.12 CAV17158.1 - 2.4 8.4 10.8 1 9.7 2.1 3.6 1 1 2 3 3 3 0 Proteins of 100 residues with WXG XhlA PF10779.9 CAV17158.1 - 3.4 7.9 6.8 16 5.7 0.2 3.1 3 0 0 3 3 3 0 Haemolysin XhlA Virul_fac_BrkB PF03631.15 CAV17159.1 - 1.1e-54 185.8 26.8 1.2e-54 185.6 26.8 1.0 1 0 0 1 1 1 1 Virulence factor BrkB Tyr_Deacylase PF02580.16 CAV17160.1 - 2e-50 171.1 0.0 2.4e-50 170.8 0.0 1.0 1 0 0 1 1 1 1 D-Tyr-tRNA(Tyr) deacylase YiiD_C PF09500.10 CAV17161.1 - 1.2e-53 180.8 0.0 1.7e-53 180.3 0.0 1.2 1 0 0 1 1 1 1 Putative thioesterase (yiiD_Cterm) Acetyltransf_10 PF13673.7 CAV17161.1 - 2.8e-09 37.0 0.0 4.9e-09 36.2 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 CAV17161.1 - 4.1e-09 36.7 0.0 6.5e-09 36.0 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 CAV17161.1 - 6e-06 26.6 0.0 1e-05 25.8 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 CAV17161.1 - 0.028 14.4 0.0 0.057 13.4 0.0 1.4 1 0 0 1 1 1 0 FR47-like protein Acetyltransf_5 PF13444.6 CAV17161.1 - 0.058 14.1 0.0 1.5 9.5 0.0 2.4 1 1 1 2 2 2 0 Acetyltransferase (GNAT) domain AsmA PF05170.14 CAV17163.1 - 2.3e-94 317.4 18.3 2.7e-94 317.1 18.3 1.0 1 0 0 1 1 1 1 AsmA family PEPCK_ATP PF01293.20 CAV17164.1 - 5.4e-209 694.6 0.0 6.3e-209 694.4 0.0 1.0 1 0 0 1 1 1 1 Phosphoenolpyruvate carboxykinase AAA_33 PF13671.6 CAV17164.1 - 0.002 18.3 0.0 0.29 11.3 0.0 2.7 3 0 0 3 3 3 2 AAA domain AAA_25 PF13481.6 CAV17164.1 - 0.075 12.6 0.1 0.61 9.6 0.0 2.4 3 0 0 3 3 3 0 AAA domain HSP33 PF01430.19 CAV17165.1 - 2e-79 266.7 0.0 2.3e-79 266.6 0.0 1.0 1 0 0 1 1 1 1 Hsp33 protein PyrI_C PF02748.15 CAV17165.1 - 0.18 11.7 0.1 0.34 10.8 0.1 1.4 1 0 0 1 1 1 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain S4 PF01479.25 CAV17166.1 - 2.4e-13 49.6 0.0 3.6e-13 49.0 0.0 1.3 1 0 0 1 1 1 1 S4 domain T2SSC PF11356.8 CAV17167.1 - 1.7e-44 151.1 0.1 3.4e-44 150.1 0.1 1.4 1 0 0 1 1 1 1 Type II secretion system protein C PDZ_2 PF13180.6 CAV17167.1 - 0.0093 16.3 0.0 0.024 14.9 0.0 1.8 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 CAV17167.1 - 0.021 14.6 0.0 0.047 13.5 0.0 1.6 1 0 0 1 1 1 0 PDZ domain Secretin PF00263.21 CAV17168.1 - 4.3e-51 172.9 3.6 4.3e-51 172.9 3.6 2.0 2 0 0 2 2 2 1 Bacterial type II and III secretion system protein Secretin_N PF03958.17 CAV17168.1 - 3.4e-44 149.1 20.0 7.7e-19 67.9 2.3 3.9 4 0 0 4 4 4 3 Bacterial type II/III secretion system short domain SdrD_B PF17210.3 CAV17168.1 - 0.055 13.7 1.2 0.077 13.2 0.1 1.8 2 0 0 2 2 2 0 SdrD B-like domain DDOST_48kD PF03345.14 CAV17168.1 - 0.21 10.4 1.1 0.44 9.3 0.5 1.8 1 1 1 2 2 2 0 Oligosaccharyltransferase 48 kDa subunit beta T2SSE PF00437.20 CAV17169.1 - 3e-91 305.3 2.5 4.3e-91 304.8 2.5 1.2 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_22 PF13401.6 CAV17169.1 - 0.00025 21.4 0.0 0.0041 17.4 0.0 2.7 3 0 0 3 3 3 1 AAA domain AAA_29 PF13555.6 CAV17169.1 - 0.0006 19.5 0.0 0.0013 18.5 0.0 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_16 PF13191.6 CAV17169.1 - 0.0013 19.2 0.1 0.0042 17.5 0.0 1.9 2 0 0 2 2 2 1 AAA ATPase domain AAA_23 PF13476.6 CAV17169.1 - 0.0019 18.7 0.3 0.0088 16.6 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_14 PF13173.6 CAV17169.1 - 0.0066 16.5 0.0 0.016 15.2 0.0 1.8 1 0 0 1 1 1 1 AAA domain Rad17 PF03215.15 CAV17169.1 - 0.014 15.4 0.0 0.026 14.4 0.0 1.4 1 0 0 1 1 1 0 Rad17 P-loop domain AAA PF00004.29 CAV17169.1 - 0.015 15.7 0.4 0.06 13.8 0.0 2.1 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_30 PF13604.6 CAV17169.1 - 0.021 14.6 0.0 0.051 13.3 0.0 1.7 1 0 0 1 1 1 0 AAA domain NTPase_1 PF03266.15 CAV17169.1 - 0.026 14.4 1.6 1.3 8.9 0.3 2.4 1 1 1 2 2 2 0 NTPase T2SSE_N PF05157.15 CAV17169.1 - 0.029 14.6 0.0 0.086 13.1 0.0 1.8 2 0 0 2 2 2 0 Type II secretion system (T2SS), protein E, N-terminal domain AAA_7 PF12775.7 CAV17169.1 - 0.052 13.1 0.0 0.092 12.3 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_11 PF13086.6 CAV17169.1 - 0.063 13.1 0.0 0.11 12.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_19 PF13245.6 CAV17169.1 - 0.065 13.6 0.1 0.23 11.8 0.0 2.0 2 0 0 2 2 1 0 AAA domain ABC_tran PF00005.27 CAV17169.1 - 0.081 13.4 0.0 0.17 12.4 0.0 1.6 1 0 0 1 1 1 0 ABC transporter AAA_18 PF13238.6 CAV17169.1 - 0.083 13.4 0.0 0.2 12.2 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_27 PF13514.6 CAV17169.1 - 0.097 12.2 0.0 0.25 10.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain Zeta_toxin PF06414.12 CAV17169.1 - 0.11 11.7 0.0 0.19 11.0 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin T2SSF PF00482.23 CAV17170.1 - 5.7e-58 194.3 13.7 3.8e-33 114.1 0.6 2.6 3 0 0 3 3 3 2 Type II secretion system (T2SS), protein F Virul_fac_BrkB PF03631.15 CAV17170.1 - 0.0067 16.1 4.0 0.031 13.9 0.9 2.2 2 0 0 2 2 2 1 Virulence factor BrkB DUF2721 PF11026.8 CAV17170.1 - 0.055 13.3 4.2 0.44 10.4 0.1 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2721) Endotoxin_mid PF09131.10 CAV17170.1 - 0.057 13.1 0.0 0.089 12.5 0.0 1.3 1 0 0 1 1 1 0 Bacillus thuringiensis delta-Endotoxin, middle domain Acetyltransf_11 PF13720.6 CAV17170.1 - 0.063 13.7 0.1 0.3 11.6 0.0 2.2 3 0 0 3 3 3 0 Udp N-acetylglucosamine O-acyltransferase; Domain 2 DUF2207 PF09972.9 CAV17170.1 - 0.066 12.0 0.1 0.47 9.2 0.0 1.9 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) Stevor PF17410.2 CAV17170.1 - 2.2 7.7 5.9 8 5.9 1.2 2.3 2 0 0 2 2 2 0 Subtelomeric Variable Open Reading frame DUF996 PF06195.13 CAV17170.1 - 6.4 7.1 11.3 13 6.0 7.4 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF996) T2SSG PF08334.11 CAV17171.1 - 1.3e-41 141.1 0.3 1.5e-41 140.9 0.3 1.0 1 0 0 1 1 1 1 Type II secretion system (T2SS), protein G N_methyl PF07963.12 CAV17171.1 - 3.9e-10 38.9 2.8 6.1e-10 38.2 2.8 1.3 1 0 0 1 1 1 1 Prokaryotic N-terminal methylation motif DUF4492 PF14899.6 CAV17171.1 - 0.1 12.5 0.1 0.15 12.0 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4492) Phage_holin_6_1 PF09682.10 CAV17171.1 - 0.11 12.9 0.3 0.16 12.4 0.3 1.2 1 0 0 1 1 1 0 Bacteriophage holin of superfamily 6 (Holin_LLH) GspH PF12019.8 CAV17172.1 - 1.2e-07 32.1 0.0 1.7e-07 31.6 0.0 1.2 1 0 0 1 1 1 1 Type II transport protein GspH N_methyl PF07963.12 CAV17172.1 - 4.2e-06 26.1 1.0 7.8e-06 25.2 1.0 1.5 1 0 0 1 1 1 1 Prokaryotic N-terminal methylation motif T2SSI PF02501.17 CAV17173.1 - 6.8e-19 67.8 0.1 1.1e-18 67.2 0.1 1.3 1 0 0 1 1 1 1 Type II secretion system (T2SS), protein I N_methyl PF07963.12 CAV17173.1 - 7.9e-06 25.2 4.1 1.6e-05 24.2 4.1 1.5 1 0 0 1 1 1 1 Prokaryotic N-terminal methylation motif PulG PF11773.8 CAV17173.1 - 0.15 11.9 1.4 0.21 11.4 1.4 1.3 1 0 0 1 1 1 0 Type II secretory pathway pseudopilin T2SSJ PF11612.8 CAV17174.1 - 3.5e-40 137.4 0.6 5.6e-40 136.8 0.6 1.3 1 0 0 1 1 1 1 Type II secretion system (T2SS), protein J N_methyl PF07963.12 CAV17174.1 - 7.8e-09 34.7 0.3 1.3e-08 34.1 0.3 1.4 1 0 0 1 1 1 1 Prokaryotic N-terminal methylation motif T2SSK PF03934.13 CAV17175.1 - 5.8e-86 288.3 1.6 6.7e-86 288.1 1.6 1.0 1 0 0 1 1 1 1 Type II secretion system (T2SS), protein K HHH_3 PF12836.7 CAV17175.1 - 0.12 12.6 0.0 27 5.1 0.0 2.6 2 0 0 2 2 2 0 Helix-hairpin-helix motif T2SSL PF05134.13 CAV17176.1 - 1.3e-62 211.2 2.7 2e-62 210.6 2.7 1.3 1 0 0 1 1 1 1 Type II secretion system (T2SS), protein L GspL_C PF12693.7 CAV17176.1 - 4.8e-49 166.2 0.8 9.3e-49 165.3 0.8 1.5 1 0 0 1 1 1 1 GspL periplasmic domain CoA_binding_3 PF13727.6 CAV17176.1 - 0.077 13.0 0.2 0.12 12.4 0.2 1.3 1 0 0 1 1 1 0 CoA-binding domain DUF4231 PF14015.6 CAV17176.1 - 1.3 9.5 5.9 0.93 10.0 2.5 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF4231) T2SSM PF04612.12 CAV17177.1 - 5.4e-54 182.6 1.8 6e-54 182.4 1.8 1.0 1 0 0 1 1 1 1 Type II secretion system (T2SS), protein M T2SSN PF01203.19 CAV17178.1 - 1.4e-61 208.4 0.7 1.6e-61 208.2 0.7 1.0 1 0 0 1 1 1 1 Type II secretion system (T2SS), protein N Inositol_P PF00459.25 CAV17179.1 - 2.4e-52 178.1 0.0 2.8e-52 177.9 0.0 1.0 1 0 0 1 1 1 1 Inositol monophosphatase family FBPase PF00316.20 CAV17179.1 - 0.19 11.2 0.0 0.28 10.6 0.0 1.3 1 0 0 1 1 1 0 Fructose-1-6-bisphosphatase, N-terminal domain NUDIX PF00293.28 CAV17180.1 - 2.9e-16 59.7 0.1 4.6e-16 59.0 0.1 1.3 1 0 0 1 1 1 1 NUDIX domain NifU PF01106.17 CAV17181.1 - 6e-19 68.0 0.3 1e-18 67.2 0.3 1.4 1 0 0 1 1 1 1 NifU-like domain Fe-S_biosyn PF01521.20 CAV17181.1 - 5.2e-13 49.2 0.0 1e-12 48.2 0.0 1.5 1 0 0 1 1 1 1 Iron-sulphur cluster biosynthesis Pribosyltran PF00156.27 CAV17182.1 - 1.2e-07 31.4 0.0 1.9e-07 30.8 0.0 1.3 1 0 0 1 1 1 1 Phosphoribosyl transferase domain UPRTase PF14681.6 CAV17182.1 - 0.0018 17.8 0.0 0.0028 17.2 0.0 1.2 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase PRTase_2 PF15609.6 CAV17182.1 - 0.14 11.6 0.0 0.23 10.9 0.0 1.4 1 0 0 1 1 1 0 Phosphoribosyl transferase zinc-ribbons_6 PF07191.12 CAV17182.1 - 2.5 8.1 8.0 4.7 7.3 8.0 1.4 1 0 0 1 1 1 0 zinc-ribbons Abhydrolase_1 PF00561.20 CAV17183.1 - 7.6e-23 81.5 0.1 3.5e-22 79.3 0.1 1.8 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CAV17183.1 - 1.8e-19 71.3 3.0 2.1e-19 71.0 3.0 1.0 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CAV17183.1 - 4.3e-15 55.6 0.1 6.8e-15 55.0 0.1 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_5 PF12695.7 CAV17183.1 - 5.5e-06 26.2 0.0 0.052 13.3 0.0 2.2 2 0 0 2 2 2 2 Alpha/beta hydrolase family Thioesterase PF00975.20 CAV17183.1 - 9.4e-06 25.9 0.3 1.1e-05 25.7 0.3 1.4 1 1 0 1 1 1 1 Thioesterase domain UPF0227 PF05728.12 CAV17183.1 - 0.0032 17.4 0.0 0.0063 16.5 0.0 1.5 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0227) PGAP1 PF07819.13 CAV17183.1 - 0.0082 15.9 0.0 0.011 15.5 0.0 1.4 1 0 0 1 1 1 1 PGAP1-like protein Esterase PF00756.20 CAV17183.1 - 0.015 15.0 0.2 0.022 14.4 0.2 1.4 1 1 0 1 1 1 0 Putative esterase FSH1 PF03959.13 CAV17183.1 - 0.017 14.8 0.0 0.22 11.2 0.0 2.5 1 1 1 2 2 2 0 Serine hydrolase (FSH1) FIST PF08495.10 CAV17183.1 - 0.032 14.2 0.0 0.047 13.7 0.0 1.3 1 0 0 1 1 1 0 FIST N domain Ndr PF03096.14 CAV17183.1 - 0.093 11.4 0.0 0.11 11.2 0.0 1.2 1 0 0 1 1 1 0 Ndr family Peptidase_S9 PF00326.21 CAV17183.1 - 0.12 11.8 0.0 1.4 8.4 0.0 2.2 2 0 0 2 2 2 0 Prolyl oligopeptidase family Tex_N PF09371.10 CAV17186.1 - 2.4e-72 242.5 1.1 4.4e-72 241.6 1.1 1.5 1 0 0 1 1 1 1 Tex-like protein N-terminal domain Tex_YqgF PF16921.5 CAV17186.1 - 7.1e-55 184.8 0.2 1.4e-54 183.9 0.2 1.5 1 0 0 1 1 1 1 Tex protein YqgF-like domain HHH_3 PF12836.7 CAV17186.1 - 2.7e-27 94.8 0.0 7e-27 93.5 0.0 1.8 1 0 0 1 1 1 1 Helix-hairpin-helix motif HHH_9 PF17674.1 CAV17186.1 - 4.6e-23 81.9 0.0 2.2e-22 79.7 0.0 2.3 1 0 0 1 1 1 1 HHH domain S1 PF00575.23 CAV17186.1 - 1.2e-21 76.8 1.7 2.3e-21 75.9 1.7 1.5 1 0 0 1 1 1 1 S1 RNA binding domain HHH_7 PF14635.6 CAV17186.1 - 3.4e-10 40.2 0.0 9.8e-10 38.7 0.0 1.8 1 0 0 1 1 1 1 Helix-hairpin-helix motif YqgF PF14639.6 CAV17186.1 - 1.1e-06 28.5 0.1 3e-06 27.1 0.1 1.8 1 0 0 1 1 1 1 Holliday-junction resolvase-like of SPT6 GreA_GreB PF01272.19 CAV17187.1 - 6.1e-24 83.7 0.0 9.2e-24 83.1 0.0 1.2 1 0 0 1 1 1 1 Transcription elongation factor, GreA/GreB, C-term GreA_GreB_N PF03449.15 CAV17187.1 - 7.4e-23 80.5 0.0 1.6e-22 79.4 0.0 1.5 2 0 0 2 2 2 1 Transcription elongation factor, N-terminal Response_reg PF00072.24 CAV17188.1 - 1e-29 103.0 0.0 1.5e-29 102.4 0.0 1.3 1 0 0 1 1 1 1 Response regulator receiver domain Trans_reg_C PF00486.28 CAV17188.1 - 8.2e-22 77.1 0.0 2e-21 75.9 0.0 1.6 1 0 0 1 1 1 1 Transcriptional regulatory protein, C terminal FleQ PF06490.11 CAV17188.1 - 0.00069 20.0 0.0 0.0013 19.1 0.0 1.5 1 0 0 1 1 1 1 Flagellar regulatory protein FleQ MEDS PF14417.6 CAV17188.1 - 0.11 12.3 0.1 0.23 11.3 0.1 1.5 1 0 0 1 1 1 0 MEDS: MEthanogen/methylotroph, DcmR Sensory domain OKR_DC_1_N PF03709.15 CAV17188.1 - 0.12 12.7 0.0 0.21 11.9 0.0 1.4 1 0 0 1 1 1 0 Orn/Lys/Arg decarboxylase, N-terminal domain HATPase_c PF02518.26 CAV17189.1 - 2.6e-22 79.4 0.0 5.6e-22 78.4 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 CAV17189.1 - 1.5e-10 41.0 0.3 1.2e-08 34.8 0.0 3.0 2 1 1 3 3 3 1 His Kinase A (phospho-acceptor) domain HAMP PF00672.25 CAV17189.1 - 1.8e-10 41.1 0.1 1.6e-09 38.0 0.0 2.4 2 0 0 2 2 2 1 HAMP domain HATPase_c_3 PF13589.6 CAV17189.1 - 0.0039 17.0 0.0 0.0069 16.2 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_2 PF13581.6 CAV17189.1 - 0.0093 15.9 0.0 0.019 14.9 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-like ATPase domain HATPase_c_5 PF14501.6 CAV17189.1 - 0.18 11.8 0.0 0.35 10.8 0.0 1.5 1 0 0 1 1 1 0 GHKL domain RecG_wedge PF17191.4 CAV17190.1 - 1.9e-22 79.6 0.0 4.9e-22 78.3 0.0 1.7 2 0 0 2 2 2 1 RecG wedge domain Helicase_C PF00271.31 CAV17190.1 - 8.6e-21 74.4 0.0 3.5e-17 62.8 0.0 2.4 2 0 0 2 2 2 2 Helicase conserved C-terminal domain DEAD PF00270.29 CAV17190.1 - 6.2e-20 71.7 0.6 1.6e-19 70.4 0.0 2.0 3 0 0 3 3 3 1 DEAD/DEAH box helicase ResIII PF04851.15 CAV17190.1 - 1.1e-11 45.1 0.0 2e-11 44.2 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit tRNA_anti-codon PF01336.25 CAV17190.1 - 1.3e-08 34.6 0.0 3.4e-08 33.3 0.0 1.7 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain SecA_DEAD PF07517.14 CAV17190.1 - 2.1e-05 24.0 0.1 4.4e-05 22.9 0.1 1.5 1 0 0 1 1 1 1 SecA DEAD-like domain AAA_30 PF13604.6 CAV17190.1 - 0.00011 22.0 0.5 0.00027 20.7 0.5 1.6 1 0 0 1 1 1 1 AAA domain DUF2075 PF09848.9 CAV17190.1 - 0.0015 17.8 0.0 0.0026 17.1 0.0 1.4 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) PhoH PF02562.16 CAV17190.1 - 0.016 14.7 0.1 0.037 13.5 0.1 1.7 1 0 0 1 1 1 0 PhoH-like protein AAA_22 PF13401.6 CAV17190.1 - 0.02 15.2 0.8 0.29 11.4 0.1 2.8 1 1 1 3 3 3 0 AAA domain Cdd1 PF11731.8 CAV17190.1 - 0.024 14.9 0.0 0.09 13.0 0.0 1.9 2 0 0 2 2 1 0 Pathogenicity locus Helicase_RecD PF05127.14 CAV17190.1 - 0.035 14.0 0.1 0.1 12.4 0.1 1.7 2 0 0 2 2 2 0 Helicase SNF2_N PF00176.23 CAV17190.1 - 0.054 12.2 0.0 0.1 11.3 0.0 1.5 2 0 0 2 2 2 0 SNF2 family N-terminal domain Glyco_tran_WecB PF03808.13 CAV17190.1 - 0.066 13.2 0.4 0.41 10.6 0.0 2.2 2 0 0 2 2 2 0 Glycosyl transferase WecB/TagA/CpsF family Glyco_tranf_2_3 PF13641.6 CAV17190.1 - 0.08 12.8 2.1 0.14 12.1 0.1 2.3 3 0 0 3 3 3 0 Glycosyltransferase like family 2 HHH_5 PF14520.6 CAV17190.1 - 0.09 13.4 0.0 0.27 11.9 0.0 1.8 1 0 0 1 1 1 0 Helix-hairpin-helix domain IMS_HHH PF11798.8 CAV17190.1 - 0.11 12.9 0.0 0.89 10.0 0.0 2.4 2 0 0 2 2 2 0 IMS family HHH motif TfoX_C PF04994.13 CAV17190.1 - 0.12 12.5 0.0 31 4.8 0.0 2.8 2 0 0 2 2 2 0 TfoX C-terminal domain HD_4 PF13328.6 CAV17191.1 - 6.1e-53 178.7 2.0 1.2e-52 177.8 2.0 1.5 1 0 0 1 1 1 1 HD domain RelA_SpoT PF04607.17 CAV17191.1 - 8.3e-34 116.4 0.1 3.4e-33 114.4 0.0 2.1 2 0 0 2 2 2 1 Region found in RelA / SpoT proteins TGS PF02824.21 CAV17191.1 - 2.8e-18 65.7 0.0 6.7e-18 64.5 0.0 1.7 1 0 0 1 1 1 1 TGS domain ACT_4 PF13291.6 CAV17191.1 - 1.5e-15 57.5 1.5 2.4e-15 56.8 0.2 2.1 2 0 0 2 2 2 1 ACT domain HD PF01966.22 CAV17191.1 - 9e-11 42.1 2.7 1.2e-10 41.7 0.9 2.1 2 0 0 2 2 2 1 HD domain ACT PF01842.25 CAV17191.1 - 1.1e-05 25.1 0.2 0.00011 21.9 0.1 2.6 2 0 0 2 2 2 1 ACT domain 4HB_MCP_1 PF12729.7 CAV17191.1 - 0.12 12.0 0.6 0.3 10.6 0.6 1.6 1 0 0 1 1 1 0 Four helix bundle sensory module for signal transduction RNA_pol_Rpb6 PF01192.22 CAV17192.1 - 2.4e-18 65.8 0.1 3.7e-18 65.2 0.1 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb6 Guanylate_kin PF00625.21 CAV17193.1 - 2.5e-60 203.3 0.0 2.9e-60 203.1 0.0 1.0 1 0 0 1 1 1 1 Guanylate kinase AAA_33 PF13671.6 CAV17193.1 - 0.0052 17.0 0.0 0.013 15.7 0.0 1.7 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 CAV17193.1 - 0.0084 16.5 0.1 0.027 14.8 0.1 1.8 1 1 0 1 1 1 1 AAA ATPase domain ABC_tran PF00005.27 CAV17193.1 - 0.011 16.2 0.0 0.017 15.7 0.0 1.5 1 1 0 1 1 1 0 ABC transporter RsgA_GTPase PF03193.16 CAV17193.1 - 0.021 14.7 0.1 0.043 13.7 0.1 1.5 1 0 0 1 1 1 0 RsgA GTPase AAA_22 PF13401.6 CAV17193.1 - 0.056 13.7 0.0 0.11 12.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain MMR_HSR1 PF01926.23 CAV17193.1 - 0.13 12.4 0.0 0.19 11.8 0.0 1.7 1 1 0 1 1 1 0 50S ribosome-binding GTPase Xan_ur_permease PF00860.20 CAV17194.1 - 1.8e-19 69.7 40.2 2e-19 69.5 39.9 1.2 1 1 0 1 1 1 1 Permease family DUF2964 PF11177.8 CAV17194.1 - 0.15 12.3 7.8 8.7 6.6 2.7 3.7 2 1 0 2 2 2 0 Protein of unknown function (DUF2964) PsiE PF06146.12 CAV17195.1 - 4.3e-14 52.6 5.5 4.3e-14 52.6 5.5 2.0 2 0 0 2 2 2 1 Phosphate-starvation-inducible E PA26 PF04636.13 CAV17195.1 - 0.031 13.2 0.5 0.035 13.0 0.5 1.1 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Alginate_exp PF13372.6 CAV17196.1 - 1.1e-25 90.3 13.7 1.5e-25 89.8 13.7 1.1 1 0 0 1 1 1 1 Alginate export PTS_EIIC PF02378.18 CAV17197.1 - 9.6e-56 189.2 37.5 1.4e-55 188.6 37.5 1.2 1 0 0 1 1 1 1 Phosphotransferase system, EIIC PTS_EIIB PF00367.20 CAV17197.1 - 2.2e-15 55.8 0.3 3.8e-15 55.1 0.3 1.4 1 0 0 1 1 1 1 phosphotransferase system, EIIB LytB_WW PF18342.1 CAV17197.1 - 0.023 14.8 0.5 0.1 12.8 0.0 2.2 2 0 0 2 2 2 0 Endo-beta-N-acetylglucosaminidase LytB WW domain Peptidase_M20 PF01546.28 CAV17198.1 - 1.2e-21 77.4 0.0 1.7e-21 76.9 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 Peptidase_M28 PF04389.17 CAV17198.1 - 0.022 14.5 0.0 0.039 13.7 0.0 1.3 1 0 0 1 1 1 0 Peptidase family M28 Rib_5-P_isom_A PF06026.14 CAV17199.1 - 8.4e-46 155.7 0.0 1.1e-45 155.3 0.0 1.1 1 0 0 1 1 1 1 Ribose 5-phosphate isomerase A (phosphoriboisomerase A) UPRTase PF14681.6 CAV17199.1 - 0.0055 16.2 0.1 0.0083 15.6 0.1 1.2 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase Sugar-bind PF04198.13 CAV17199.1 - 0.015 14.4 0.0 0.022 13.9 0.0 1.2 1 0 0 1 1 1 0 Putative sugar-binding domain Pribosyltran PF00156.27 CAV17199.1 - 0.19 11.3 0.3 2.6 7.5 0.0 2.1 2 0 0 2 2 2 0 Phosphoribosyl transferase domain Transketolase_N PF00456.21 CAV17200.1 - 6.8e-166 551.2 0.0 9.3e-166 550.8 0.0 1.2 1 0 0 1 1 1 1 Transketolase, thiamine diphosphate binding domain Transket_pyr PF02779.24 CAV17200.1 - 4.2e-46 156.9 0.0 7.7e-46 156.0 0.0 1.4 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.20 CAV17200.1 - 5.1e-14 52.2 0.1 1.2e-13 51.0 0.0 1.7 2 0 0 2 2 2 1 Transketolase, C-terminal domain DXP_synthase_N PF13292.6 CAV17200.1 - 4.8e-07 29.3 0.0 0.0046 16.2 0.0 2.4 1 1 1 2 2 2 2 1-deoxy-D-xylulose-5-phosphate synthase E1_dh PF00676.20 CAV17200.1 - 0.0027 16.7 0.0 0.0053 15.7 0.0 1.4 1 0 0 1 1 1 1 Dehydrogenase E1 component TPP_enzyme_C PF02775.21 CAV17200.1 - 0.0037 17.0 0.4 0.18 11.6 0.4 2.5 1 1 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain TAL_FSA PF00923.19 CAV17201.1 - 8.7e-99 330.5 0.1 9.8e-99 330.3 0.1 1.0 1 0 0 1 1 1 1 Transaldolase/Fructose-6-phosphate aldolase HAD_2 PF13419.6 CAV17202.1 - 7.5e-33 114.1 0.0 9.8e-33 113.7 0.0 1.1 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 CAV17202.1 - 1.1e-14 55.3 0.0 5.6e-14 52.9 0.0 1.9 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 CAV17202.1 - 8.2e-06 25.8 0.0 1.6e-05 24.9 0.0 1.5 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase_6 PF13344.6 CAV17202.1 - 0.025 14.7 0.0 9.4 6.4 0.0 3.1 2 1 2 4 4 4 0 Haloacid dehalogenase-like hydrolase Fe-ADH PF00465.19 CAV17203.1 - 4.6e-106 354.7 0.0 5.5e-106 354.5 0.0 1.0 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase Fe-ADH_2 PF13685.6 CAV17203.1 - 9.6e-17 61.5 0.1 3.9e-08 33.3 0.0 2.1 2 0 0 2 2 2 2 Iron-containing alcohol dehydrogenase Ribul_P_3_epim PF00834.19 CAV17204.1 - 3.3e-27 95.2 0.1 4e-27 94.9 0.1 1.1 1 0 0 1 1 1 1 Ribulose-phosphate 3 epimerase family QRPTase_C PF01729.19 CAV17204.1 - 0.00017 21.4 0.0 0.011 15.6 0.0 2.4 2 0 0 2 2 2 1 Quinolinate phosphoribosyl transferase, C-terminal domain His_biosynth PF00977.21 CAV17204.1 - 0.0013 18.2 0.1 0.0083 15.6 0.0 2.0 2 0 0 2 2 2 1 Histidine biosynthesis protein RuBisCO_large PF00016.20 CAV17204.1 - 0.029 13.6 0.0 0.1 11.8 0.0 1.7 2 0 0 2 2 2 0 Ribulose bisphosphate carboxylase large chain, catalytic domain TMP-TENI PF02581.17 CAV17204.1 - 0.074 12.4 1.1 3.6 6.9 0.0 2.3 2 0 0 2 2 2 0 Thiamine monophosphate synthase Hydrolase_3 PF08282.12 CAV17205.1 - 9.6e-58 195.9 0.1 1.1e-57 195.7 0.1 1.0 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase S6PP PF05116.13 CAV17205.1 - 8e-13 48.5 0.1 8.5e-09 35.3 0.1 2.1 2 0 0 2 2 2 2 Sucrose-6F-phosphate phosphohydrolase Hydrolase PF00702.26 CAV17205.1 - 5.6e-06 26.8 0.0 3.5e-05 24.2 0.0 1.9 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 CAV17205.1 - 0.00081 19.8 0.1 0.34 11.3 0.0 3.1 1 1 1 3 3 3 1 haloacid dehalogenase-like hydrolase DeoRC PF00455.22 CAV17206.1 - 4.2e-32 111.3 0.2 6e-32 110.8 0.2 1.2 1 0 0 1 1 1 1 DeoR C terminal sensor domain HTH_DeoR PF08220.12 CAV17206.1 - 5.8e-13 48.4 0.4 1.1e-12 47.5 0.4 1.4 1 0 0 1 1 1 1 DeoR-like helix-turn-helix domain HTH_11 PF08279.12 CAV17206.1 - 0.0012 18.7 0.8 0.0098 15.8 0.2 2.4 2 0 0 2 2 2 1 HTH domain Ribosomal_S25 PF03297.15 CAV17206.1 - 0.071 13.3 0.0 0.14 12.4 0.0 1.4 1 0 0 1 1 1 0 S25 ribosomal protein RepL PF05732.11 CAV17206.1 - 0.084 12.3 0.0 0.13 11.7 0.0 1.2 1 0 0 1 1 1 0 Firmicute plasmid replication protein (RepL) Replic_Relax PF13814.6 CAV17206.1 - 0.13 12.3 0.0 2.1 8.3 0.0 2.2 2 0 0 2 2 2 0 Replication-relaxation CSD PF00313.22 CAV17207.1 - 2.4e-29 101.0 3.1 2.6e-29 100.9 3.1 1.0 1 0 0 1 1 1 1 'Cold-shock' DNA-binding domain OB_RNB PF08206.11 CAV17207.1 - 0.00032 20.3 0.4 0.00041 20.0 0.4 1.3 1 1 0 1 1 1 1 Ribonuclease B OB domain CusF_Ec PF11604.8 CAV17207.1 - 0.0052 16.7 0.1 0.0083 16.1 0.1 1.3 1 0 0 1 1 1 1 Copper binding periplasmic protein CusF S1 PF00575.23 CAV17207.1 - 0.057 13.8 0.0 0.064 13.6 0.0 1.1 1 0 0 1 1 1 0 S1 RNA binding domain YicC_N PF03755.13 CAV17208.1 - 1.7e-43 148.6 0.7 2.8e-43 148.0 0.1 1.7 2 0 0 2 2 2 1 YicC-like family, N-terminal region DUF1732 PF08340.11 CAV17208.1 - 6.2e-34 115.8 1.6 6.2e-34 115.8 1.6 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF1732) PAP_central PF04928.17 CAV17208.1 - 0.0071 15.3 0.3 0.012 14.6 0.3 1.3 1 0 0 1 1 1 1 Poly(A) polymerase central domain SKA2 PF16740.5 CAV17208.1 - 0.096 12.5 0.3 0.096 12.5 0.3 2.1 2 1 0 2 2 2 0 Spindle and kinetochore-associated protein 2 RNase_PH PF01138.21 CAV17209.1 - 2e-23 83.3 0.1 3.3e-23 82.6 0.1 1.3 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 CAV17209.1 - 1.9e-11 43.8 0.3 6.8e-11 42.0 0.4 1.8 2 0 0 2 2 2 1 3' exoribonuclease family, domain 2 Pribosyltran PF00156.27 CAV17210.1 - 1.8e-12 47.1 0.1 2.6e-12 46.5 0.1 1.2 1 0 0 1 1 1 1 Phosphoribosyl transferase domain PRTase_2 PF15609.6 CAV17210.1 - 0.071 12.6 0.1 0.14 11.6 0.1 1.4 1 1 0 1 1 1 0 Phosphoribosyl transferase Lip_A_acyltrans PF03279.13 CAV17211.1 - 1.4e-72 244.4 0.0 1.6e-72 244.2 0.0 1.0 1 0 0 1 1 1 1 Bacterial lipid A biosynthesis acyltransferase TetR_N PF00440.23 CAV17212.1 - 2e-09 37.1 0.1 3.8e-09 36.2 0.1 1.5 1 0 0 1 1 1 1 Bacterial regulatory proteins, tetR family HTH_AsnC-type PF13404.6 CAV17212.1 - 0.0052 16.6 0.2 0.028 14.3 0.1 2.3 2 0 0 2 2 2 1 AsnC-type helix-turn-helix domain TetR_C_24 PF17932.1 CAV17212.1 - 0.009 16.3 0.5 0.015 15.6 0.1 1.6 2 0 0 2 2 2 1 Tetracyclin repressor-like, C-terminal domain TetR_C_15 PF17918.1 CAV17212.1 - 0.012 16.4 2.2 0.067 13.9 0.2 2.5 1 1 2 3 3 3 0 Tetracyclin repressor-like, C-terminal domain TetR_C_4 PF08359.11 CAV17212.1 - 0.013 15.7 0.1 0.019 15.1 0.1 1.2 1 0 0 1 1 1 0 YsiA-like protein, C-terminal region TetR_C_6 PF13977.6 CAV17212.1 - 0.043 14.0 1.3 0.067 13.4 0.2 1.9 2 1 0 2 2 2 0 BetI-type transcriptional repressor, C-terminal TetR_C_13 PF16925.5 CAV17212.1 - 0.058 13.3 0.1 0.16 12.0 0.0 1.7 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain TetR_C_37 PF18665.1 CAV17212.1 - 0.095 13.3 0.8 1.5 9.4 0.0 2.4 3 0 0 3 3 3 0 Tetracyclin repressor-like, C-terminal domain HTH_7 PF02796.15 CAV17212.1 - 0.11 12.6 0.2 0.32 11.1 0.0 2.0 2 1 0 2 2 2 0 Helix-turn-helix domain of resolvase MICSWaP PF17018.5 CAV17212.1 - 0.16 11.5 0.1 0.73 9.4 0.0 1.9 2 0 0 2 2 2 0 Spore wall protein HTH_18 PF12833.7 CAV17212.1 - 0.17 12.2 1.4 0.71 10.2 0.0 2.4 2 1 0 2 2 2 0 Helix-turn-helix domain DFP PF04127.15 CAV17213.1 - 1.2e-78 263.2 4.8 1.7e-77 259.5 1.0 2.2 2 0 0 2 2 2 2 DNA / pantothenate metabolism flavoprotein Flavoprotein PF02441.19 CAV17213.1 - 3.9e-45 153.4 0.1 6.7e-45 152.7 0.1 1.4 1 0 0 1 1 1 1 Flavoprotein NAD_binding_7 PF13241.6 CAV17213.1 - 0.0099 16.3 0.3 4.2 7.9 0.0 2.6 2 0 0 2 2 2 2 Putative NAD(P)-binding DUF166 PF02593.14 CAV17213.1 - 0.014 14.9 0.3 0.078 12.5 0.3 1.9 2 0 0 2 2 2 0 Domain of unknown function Glyco_transf_4 PF13439.6 CAV17213.1 - 0.023 14.7 0.0 10 6.1 0.0 3.1 3 0 0 3 3 3 0 Glycosyltransferase Family 4 Gly_kinase PF02595.15 CAV17213.1 - 0.023 13.7 0.9 1.3 7.9 0.1 2.3 2 0 0 2 2 2 0 Glycerate kinase family YjeF_N PF03853.15 CAV17213.1 - 0.024 14.6 0.5 8.1 6.3 0.0 2.6 3 0 0 3 3 3 0 YjeF-related protein N-terminus Glyco_trans_4_4 PF13579.6 CAV17213.1 - 0.04 14.3 1.3 1.5 9.3 0.5 2.9 2 1 0 2 2 2 0 Glycosyl transferase 4-like domain NAD_synthase PF02540.17 CAV17213.1 - 0.058 12.5 0.0 0.1 11.7 0.0 1.4 1 0 0 1 1 1 0 NAD synthase adh_short_C2 PF13561.6 CAV17213.1 - 0.45 10.0 5.6 0.43 10.1 2.5 2.3 2 1 0 2 2 2 0 Enoyl-(Acyl carrier protein) reductase RadC PF04002.15 CAV17214.1 - 4.3e-45 152.6 0.0 6.1e-45 152.1 0.0 1.2 1 0 0 1 1 1 1 RadC-like JAB domain Prok-JAB PF14464.6 CAV17214.1 - 0.0001 22.0 0.0 0.00016 21.5 0.0 1.3 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain Ribosomal_L28 PF00830.19 CAV17215.1 - 4.8e-26 90.7 3.1 5.6e-26 90.5 3.1 1.1 1 0 0 1 1 1 1 Ribosomal L28 family Ribosomal_L33 PF00471.20 CAV17216.1 - 1.1e-16 61.0 0.0 1.2e-16 60.8 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein L33 Fapy_DNA_glyco PF01149.24 CAV17218.1 - 4.4e-32 111.1 0.0 8.6e-32 110.2 0.0 1.5 1 0 0 1 1 1 1 Formamidopyrimidine-DNA glycosylase N-terminal domain H2TH PF06831.14 CAV17218.1 - 2.9e-29 100.9 0.0 5e-29 100.1 0.0 1.4 1 0 0 1 1 1 1 Formamidopyrimidine-DNA glycosylase H2TH domain zf-FPG_IleRS PF06827.14 CAV17218.1 - 6.5e-07 29.1 1.1 1.4e-06 28.1 1.1 1.6 1 0 0 1 1 1 1 Zinc finger found in FPG and IleRS Zn_Tnp_IS1595 PF12760.7 CAV17218.1 - 0.0073 16.3 0.7 0.013 15.4 0.7 1.4 1 0 0 1 1 1 1 Transposase zinc-ribbon domain FbpA PF05833.11 CAV17218.1 - 0.13 11.0 0.0 0.2 10.4 0.0 1.2 1 0 0 1 1 1 0 Fibronectin-binding protein A N-terminus (FbpA) Glyco_transf_90 PF05686.12 CAV17219.1 - 4.7e-14 52.1 0.5 6.6e-14 51.6 0.5 1.1 1 0 0 1 1 1 1 Glycosyl transferase family 90 Glyco_trans_1_2 PF13524.6 CAV17219.1 - 0.00039 20.8 0.0 0.00084 19.7 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glycos_transf_1 PF00534.20 CAV17219.1 - 0.066 12.7 0.0 0.14 11.7 0.0 1.5 1 0 0 1 1 1 0 Glycosyl transferases group 1 Glyco_transf_9 PF01075.17 CAV17220.1 - 5.7e-70 235.5 0.0 6.9e-70 235.2 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 9 (heptosyltransferase) PS_pyruv_trans PF04230.13 CAV17220.1 - 0.14 12.1 0.0 6.7 6.5 0.0 2.4 2 1 0 2 2 2 0 Polysaccharide pyruvyl transferase Glycos_transf_N PF04413.16 CAV17221.1 - 9.9e-62 207.7 0.0 1.5e-61 207.1 0.0 1.3 1 0 0 1 1 1 1 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase) Epimerase_2 PF02350.19 CAV17221.1 - 0.018 13.9 0.2 0.26 10.1 0.0 2.1 1 1 1 2 2 2 0 UDP-N-acetylglucosamine 2-epimerase Glyco_transf_25 PF01755.17 CAV17222.1 - 5.9e-14 52.4 0.3 1.2e-13 51.4 0.3 1.6 1 1 0 1 1 1 1 Glycosyltransferase family 25 (LPS biosynthesis protein) EccE PF11203.8 CAV17223.1 - 0.017 15.4 0.0 0.027 14.8 0.0 1.3 1 0 0 1 1 1 0 Putative type VII ESX secretion system translocon, EccE TraC_F_IV PF11130.8 CAV17223.1 - 0.14 11.7 0.0 0.56 9.8 0.0 1.8 2 0 0 2 2 2 0 F pilus assembly Type-IV secretion system for plasmid transfer Kdo PF06293.14 CAV17224.1 - 1.6e-60 204.0 0.4 2.3e-60 203.5 0.4 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 CAV17224.1 - 2.2e-10 40.5 0.0 3.1e-10 40.0 0.0 1.2 1 0 0 1 1 1 1 RIO1 family Pkinase PF00069.25 CAV17224.1 - 1.2e-06 28.2 1.8 1.7e-06 27.6 0.4 1.8 2 0 0 2 2 2 1 Protein kinase domain APH PF01636.23 CAV17224.1 - 3.3e-06 27.2 1.9 0.002 18.1 1.1 2.3 1 1 1 2 2 2 2 Phosphotransferase enzyme family Haspin_kinase PF12330.8 CAV17224.1 - 0.0043 16.0 0.4 0.0082 15.1 0.2 1.5 1 1 0 1 1 1 1 Haspin like kinase domain Seadorna_VP7 PF07387.11 CAV17224.1 - 0.021 13.9 0.1 0.028 13.5 0.1 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 Choline_kinase PF01633.20 CAV17224.1 - 0.035 13.7 0.7 0.07 12.7 0.7 1.5 1 1 0 1 1 1 0 Choline/ethanolamine kinase Pkinase_Tyr PF07714.17 CAV17224.1 - 0.066 12.5 0.1 0.088 12.1 0.1 1.2 1 0 0 1 1 1 0 Protein tyrosine kinase PI3_PI4_kinase PF00454.27 CAV17224.1 - 0.069 12.9 0.1 0.11 12.2 0.1 1.4 1 0 0 1 1 1 0 Phosphatidylinositol 3- and 4-kinase OprF PF05736.11 CAV17224.1 - 0.11 12.3 0.0 4.1 7.1 0.0 2.1 2 0 0 2 2 2 0 OprF membrane domain Glyco_transf_9 PF01075.17 CAV17225.1 - 6.1e-23 81.4 0.0 8.1e-23 81.0 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 9 (heptosyltransferase) PS_pyruv_trans PF04230.13 CAV17225.1 - 0.045 13.7 0.0 2.9 7.7 0.0 2.2 2 0 0 2 2 2 0 Polysaccharide pyruvyl transferase Glyco_transf_9 PF01075.17 CAV17226.1 - 7.8e-55 185.9 0.0 9.8e-55 185.6 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 9 (heptosyltransferase) CTP_transf_like PF01467.26 CAV17227.1 - 8.2e-18 65.0 0.0 9.7e-18 64.7 0.0 1.1 1 0 0 1 1 1 1 Cytidylyltransferase-like Citrate_ly_lig PF08218.11 CAV17227.1 - 0.0003 20.5 0.0 0.00043 20.0 0.0 1.3 1 0 0 1 1 1 1 Citrate lyase ligase C-terminal domain Glycos_transf_1 PF00534.20 CAV17228.1 - 9.3e-12 44.8 0.0 1.7e-11 44.0 0.0 1.5 1 1 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 CAV17228.1 - 8.2e-11 42.5 0.0 1.4e-10 41.7 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 CAV17228.1 - 0.0006 19.8 3.0 0.05 13.6 3.1 2.3 1 1 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_trans_4_4 PF13579.6 CAV17228.1 - 0.051 14.0 0.4 0.16 12.4 0.1 1.8 1 1 1 2 2 2 0 Glycosyl transferase 4-like domain Hexapep PF00132.24 CAV17230.1 - 3.5e-09 36.0 11.8 7.7e-05 22.3 2.9 2.7 2 0 0 2 2 2 2 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 CAV17230.1 - 0.00019 21.1 4.3 0.00071 19.3 0.9 2.5 2 0 0 2 2 2 1 Hexapeptide repeat of succinyl-transferase SNF PF00209.18 CAV17230.1 - 0.078 11.7 0.0 0.11 11.2 0.0 1.1 1 0 0 1 1 1 0 Sodium:neurotransmitter symporter family Lip_A_acyltrans PF03279.13 CAV17231.1 - 2.2e-82 276.5 0.0 2.5e-82 276.4 0.0 1.0 1 0 0 1 1 1 1 Bacterial lipid A biosynthesis acyltransferase Mga PF05043.13 CAV17231.1 - 0.061 13.9 0.0 0.13 12.9 0.0 1.4 1 0 0 1 1 1 0 Mga helix-turn-helix domain Exosortase_EpsH PF09721.10 CAV17231.1 - 0.085 12.4 0.0 0.16 11.4 0.0 1.3 1 0 0 1 1 1 0 Transmembrane exosortase (Exosortase_EpsH) Epimerase PF01370.21 CAV17233.1 - 4.6e-45 154.0 0.2 6e-45 153.6 0.2 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 CAV17233.1 - 2.4e-18 66.7 1.3 7.6e-18 65.0 1.3 1.7 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase 3Beta_HSD PF01073.19 CAV17233.1 - 4.6e-12 45.5 0.0 6.1e-12 45.1 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family RmlD_sub_bind PF04321.17 CAV17233.1 - 7.3e-06 25.3 0.1 2.7e-05 23.4 0.0 1.8 2 0 0 2 2 2 1 RmlD substrate binding domain Polysacc_synt_2 PF02719.15 CAV17233.1 - 9.9e-06 24.9 0.0 0.089 11.9 0.0 2.1 2 0 0 2 2 2 2 Polysaccharide biosynthesis protein ThiF PF00899.21 CAV17233.1 - 0.00092 18.6 0.2 0.74 9.1 0.2 2.2 2 0 0 2 2 2 2 ThiF family adh_short PF00106.25 CAV17233.1 - 0.0047 16.4 0.0 0.011 15.2 0.0 1.7 1 0 0 1 1 1 1 short chain dehydrogenase NAD_binding_4 PF07993.12 CAV17233.1 - 0.0083 15.3 0.1 0.77 8.9 0.0 2.4 1 1 0 2 2 2 1 Male sterility protein NAD_binding_10 PF13460.6 CAV17233.1 - 0.016 15.1 0.0 0.034 14.1 0.0 1.6 1 0 0 1 1 1 0 NAD(P)H-binding KR PF08659.10 CAV17233.1 - 0.026 14.5 0.8 0.11 12.3 0.4 2.3 2 1 0 2 2 2 0 KR domain TrkA_N PF02254.18 CAV17233.1 - 0.067 13.5 0.1 0.13 12.5 0.1 1.5 1 0 0 1 1 1 0 TrkA-N domain NmrA PF05368.13 CAV17233.1 - 0.074 12.6 0.0 0.13 11.8 0.0 1.4 1 0 0 1 1 1 0 NmrA-like family TetR PF13972.6 CAV17234.1 - 1e-41 142.0 3.4 1.4e-41 141.6 3.4 1.1 1 0 0 1 1 1 1 Bacterial transcriptional repressor TetR_N PF00440.23 CAV17234.1 - 7.9e-13 48.0 0.0 1.8e-12 46.8 0.0 1.6 2 0 0 2 2 2 1 Bacterial regulatory proteins, tetR family HAD_2 PF13419.6 CAV17234.1 - 0.011 15.9 0.2 0.021 14.9 0.2 1.5 1 0 0 1 1 1 0 Haloacid dehalogenase-like hydrolase HTH_10 PF04967.12 CAV17234.1 - 0.051 13.4 0.0 0.11 12.3 0.0 1.6 1 0 0 1 1 1 0 HTH DNA binding domain TetR_C_37 PF18665.1 CAV17234.1 - 0.07 13.7 2.1 0.078 13.6 0.7 1.7 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain HTH_5 PF01022.20 CAV17234.1 - 0.079 12.8 0.0 0.18 11.7 0.0 1.6 1 0 0 1 1 1 0 Bacterial regulatory protein, arsR family HrcA_DNA-bdg PF03444.15 CAV17234.1 - 0.14 11.8 0.0 0.36 10.5 0.0 1.8 1 0 0 1 1 1 0 Winged helix-turn-helix transcription repressor, HrcA DNA-binding Peptidase_M23 PF01551.22 CAV17235.1 - 1.4e-25 89.3 3.1 1.9e-25 88.9 0.1 2.4 3 0 0 3 3 3 1 Peptidase family M23 GAS PF13851.6 CAV17235.1 - 0.01 15.2 14.1 0.01 15.2 14.1 2.6 1 1 0 2 2 2 0 Growth-arrest specific micro-tubule binding TRAF_BIRC3_bd PF16673.5 CAV17235.1 - 0.5 10.2 15.4 0.97 9.3 1.9 3.7 3 0 0 3 3 3 0 TNF receptor-associated factor BIRC3 binding domain DHR10 PF18595.1 CAV17235.1 - 6.1 6.9 40.3 0.077 13.1 13.8 3.4 2 1 1 3 3 3 0 Designed helical repeat protein 10 domain TFIIA PF03153.13 CAV17235.1 - 6.9 6.6 18.4 9.3 6.1 18.4 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit SATase_N PF06426.14 CAV17236.1 - 3.9e-38 130.0 0.3 6.3e-38 129.4 0.3 1.3 1 0 0 1 1 1 1 Serine acetyltransferase, N-terminal Hexapep PF00132.24 CAV17236.1 - 1e-10 40.9 6.9 4e-09 35.8 0.7 2.6 3 0 0 3 3 3 2 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 CAV17236.1 - 0.016 15.0 5.3 0.26 11.1 1.3 2.4 2 0 0 2 2 2 0 Hexapeptide repeat of succinyl-transferase NAD_Gly3P_dh_C PF07479.14 CAV17237.1 - 6.8e-52 175.5 0.4 1.1e-51 174.8 0.5 1.4 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus NAD_Gly3P_dh_N PF01210.23 CAV17237.1 - 1.6e-44 151.7 0.0 2.3e-44 151.2 0.0 1.2 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus ApbA PF02558.16 CAV17237.1 - 2.4e-07 30.5 0.0 4.9e-07 29.5 0.0 1.5 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA F420_oxidored PF03807.17 CAV17237.1 - 0.00064 20.2 0.0 0.0038 17.8 0.0 2.2 2 0 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent Pyr_redox_2 PF07992.14 CAV17237.1 - 0.0031 16.8 0.0 0.022 14.0 0.0 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase 3HCDH_N PF02737.18 CAV17237.1 - 0.006 16.5 0.0 0.01 15.7 0.0 1.4 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain GIDA PF01134.22 CAV17237.1 - 0.01 15.0 0.4 0.024 13.7 0.1 1.7 2 0 0 2 2 2 1 Glucose inhibited division protein A NAD_binding_2 PF03446.15 CAV17237.1 - 0.014 15.5 0.0 0.032 14.4 0.0 1.6 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_8 PF13450.6 CAV17237.1 - 0.035 14.3 0.0 0.1 12.8 0.0 1.8 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain NAD_binding_7 PF13241.6 CAV17237.1 - 0.098 13.1 0.0 2.9 8.4 0.0 2.3 2 0 0 2 2 2 0 Putative NAD(P)-binding SecB PF02556.14 CAV17238.1 - 7.7e-55 184.7 0.1 9.7e-55 184.4 0.1 1.0 1 0 0 1 1 1 1 Preprotein translocase subunit SecB Rhodanese PF00581.20 CAV17239.1 - 4.2e-19 69.0 0.0 5.2e-19 68.8 0.0 1.1 1 0 0 1 1 1 1 Rhodanese-like domain LacAB_rpiB PF02502.18 CAV17239.1 - 0.0065 16.5 0.4 0.34 10.9 0.0 2.1 2 0 0 2 2 2 2 Ribose/Galactose Isomerase ApbA PF02558.16 CAV17239.1 - 0.051 13.2 0.1 0.085 12.5 0.1 1.4 1 1 0 1 1 1 0 Ketopantoate reductase PanE/ApbA TraT PF05818.12 CAV17240.1 - 2.9 7.5 12.0 3.2 7.4 12.0 1.1 1 0 0 1 1 1 0 Enterobacterial TraT complement resistance protein YjbF PF11102.8 CAV17241.1 - 1e-62 211.3 0.3 1.2e-62 211.1 0.3 1.0 1 0 0 1 1 1 1 Group 4 capsule polysaccharide lipoprotein gfcB, YjbF Caps_synth_GfcC PF06251.11 CAV17242.1 - 2e-36 125.7 3.8 1.1e-27 97.2 0.0 2.1 2 0 0 2 2 2 2 Capsule biosynthesis GfcC PBP_like_2 PF12849.7 CAV17242.1 - 0.056 13.1 0.1 4.9 6.7 0.0 2.1 1 1 0 2 2 2 0 PBP superfamily domain YjbH PF06082.11 CAV17243.1 - 1.2e-256 853.7 12.0 1.4e-256 853.5 12.0 1.0 1 0 0 1 1 1 1 Exopolysaccharide biosynthesis protein YbjH Poly_export PF02563.16 CAV17244.1 - 2.2e-26 91.9 0.2 9.9e-26 89.8 0.1 2.1 2 0 0 2 2 2 1 Polysaccharide biosynthesis/export protein Wza_C PF18412.1 CAV17244.1 - 7.4e-17 60.8 0.6 7.4e-17 60.8 0.6 2.0 2 0 0 2 2 2 1 Outer-membrane lipoprotein Wza C-terminal domain SLBB PF10531.9 CAV17244.1 - 8.7e-17 60.7 1.1 2.5e-08 33.7 0.0 2.8 3 0 0 3 3 3 2 SLBB domain LMWPc PF01451.21 CAV17245.1 - 2.4e-37 128.4 0.0 2.8e-37 128.3 0.0 1.0 1 0 0 1 1 1 1 Low molecular weight phosphotyrosine protein phosphatase GNVR PF13807.6 CAV17246.1 - 3e-33 113.6 2.1 3e-33 113.6 2.1 2.7 3 0 0 3 3 3 1 G-rich domain on putative tyrosine kinase Wzz PF02706.15 CAV17246.1 - 2e-20 72.9 1.8 3.5e-20 72.1 0.1 2.4 2 0 0 2 2 2 1 Chain length determinant protein AAA_31 PF13614.6 CAV17246.1 - 7.9e-12 45.4 0.7 1.1e-10 41.7 0.0 2.7 2 1 0 2 2 2 1 AAA domain ParA PF10609.9 CAV17246.1 - 5.2e-06 26.1 0.0 1.6e-05 24.5 0.0 1.8 2 0 0 2 2 2 1 NUBPL iron-transfer P-loop NTPase CbiA PF01656.23 CAV17246.1 - 1.8e-05 24.8 0.0 9.2e-05 22.5 0.0 2.3 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_26 PF13500.6 CAV17246.1 - 0.00017 21.5 0.0 0.02 14.7 0.0 2.6 2 0 0 2 2 2 1 AAA domain ArsA_ATPase PF02374.15 CAV17246.1 - 0.0018 17.6 1.6 2.8 7.0 0.1 3.6 3 1 0 4 4 4 2 Anion-transporting ATPase MipZ PF09140.11 CAV17246.1 - 0.0023 17.3 0.0 0.0042 16.4 0.0 1.4 1 0 0 1 1 1 1 ATPase MipZ Fer4_NifH PF00142.18 CAV17246.1 - 0.016 14.7 0.0 0.043 13.3 0.0 1.7 1 0 0 1 1 1 0 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family CBP_BcsQ PF06564.12 CAV17246.1 - 0.028 13.9 0.0 0.049 13.1 0.0 1.4 1 0 0 1 1 1 0 Cellulose biosynthesis protein BcsQ IstB_IS21 PF01695.17 CAV17246.1 - 0.031 14.0 0.0 0.063 13.0 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein Occludin_ELL PF07303.13 CAV17246.1 - 0.34 11.6 3.5 5.7 7.7 1.1 2.6 2 0 0 2 2 2 0 Occludin homology domain DAHP_synth_1 PF00793.20 CAV17247.1 - 5e-58 196.1 0.0 5.6e-58 196.0 0.0 1.0 1 0 0 1 1 1 1 DAHP synthetase I family NeuB PF03102.14 CAV17247.1 - 0.026 14.0 0.0 0.065 12.7 0.0 1.5 1 1 0 1 1 1 0 NeuB family Hydrolase_3 PF08282.12 CAV17248.1 - 3.6e-07 30.2 0.0 9.3e-07 28.8 0.0 1.6 1 1 1 2 2 2 1 haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 CAV17248.1 - 0.00013 22.3 0.2 0.018 15.4 0.0 2.3 1 1 1 2 2 2 2 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 CAV17248.1 - 0.0037 17.4 0.8 0.01 16.0 0.0 2.1 2 1 1 3 3 3 1 Haloacid dehalogenase-like hydrolase CTP_transf_3 PF02348.19 CAV17249.1 - 1.3e-49 169.2 0.0 1.7e-49 168.8 0.0 1.1 1 0 0 1 1 1 1 Cytidylyltransferase NTP_transf_3 PF12804.7 CAV17249.1 - 6.2e-07 29.9 0.0 7.3e-07 29.7 0.0 1.3 1 0 0 1 1 1 1 MobA-like NTP transferase domain YflT PF11181.8 CAV17249.1 - 0.026 15.0 0.2 0.084 13.4 0.1 1.8 2 0 0 2 2 2 0 Heat induced stress protein YflT NTP_transferase PF00483.23 CAV17249.1 - 0.095 12.3 0.0 0.15 11.6 0.0 1.4 1 1 0 1 1 1 0 Nucleotidyl transferase SIS PF01380.22 CAV17250.1 - 6.9e-30 103.6 0.0 1.3e-29 102.7 0.0 1.4 2 0 0 2 2 2 1 SIS domain CBS PF00571.28 CAV17250.1 - 8.7e-10 38.9 0.3 3e-05 24.4 0.0 2.5 2 0 0 2 2 2 2 CBS domain SIS_2 PF13580.6 CAV17250.1 - 0.00015 21.8 0.2 0.0061 16.6 0.0 2.3 1 1 1 2 2 2 1 SIS domain O-ag_pol_Wzy PF14296.6 CAV17251.1 - 6.5e-15 54.7 87.8 9.4e-15 54.2 87.5 1.4 1 1 0 1 1 1 1 O-antigen polysaccharide polymerase Wzy Glycos_transf_2 PF00535.26 CAV17252.1 - 1.6e-29 102.9 0.3 2.6e-29 102.2 0.3 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_2 PF10111.9 CAV17252.1 - 4.3e-14 52.6 1.2 7.1e-14 51.9 1.1 1.5 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_3 PF13641.6 CAV17252.1 - 8.5e-10 38.9 0.0 1.2e-09 38.4 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 MAF_flag10 PF01973.18 CAV17253.1 - 5.8e-15 55.4 0.8 1.2e-14 54.4 0.8 1.5 1 1 0 1 1 1 1 Protein of unknown function DUF115 DUF621 PF04789.15 CAV17253.1 - 0.056 12.6 0.4 0.092 11.9 0.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF621) Polysacc_synt PF01943.17 CAV17254.1 - 1.3e-10 41.1 55.2 5.9e-10 39.0 34.4 2.1 1 1 1 2 2 2 2 Polysaccharide biosynthesis protein Polysacc_synt_C PF14667.6 CAV17254.1 - 4.8e-10 39.6 8.7 4.8e-10 39.6 8.7 3.9 1 1 3 4 4 4 1 Polysaccharide biosynthesis C-terminal domain TaqI_C PF12950.7 CAV17254.1 - 0.12 12.5 0.1 0.12 12.5 0.1 2.1 2 0 0 2 2 2 0 TaqI-like C-terminal specificity domain Hexapep PF00132.24 CAV17256.1 - 1.2e-13 50.1 9.8 9.6e-11 41.0 3.2 3.2 2 1 0 2 2 2 2 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 CAV17256.1 - 2.9e-11 42.9 6.5 1e-08 34.8 1.7 2.5 2 0 0 2 2 2 2 Hexapeptide repeat of succinyl-transferase Glycos_transf_1 PF00534.20 CAV17257.1 - 2e-16 60.0 0.1 3.3e-16 59.3 0.1 1.3 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 CAV17257.1 - 4.7e-09 36.8 0.0 7.6e-09 36.1 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferases group 1 GDP_Man_Dehyd PF16363.5 CAV17258.1 - 1.1e-95 320.9 0.0 1.2e-95 320.7 0.0 1.0 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 CAV17258.1 - 3.4e-72 242.8 0.0 4.2e-72 242.5 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 CAV17258.1 - 1.4e-13 50.5 0.0 2.3e-13 49.8 0.0 1.3 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Polysacc_synt_2 PF02719.15 CAV17258.1 - 6e-13 48.6 0.0 9.9e-13 47.9 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein NAD_binding_4 PF07993.12 CAV17258.1 - 5.1e-12 45.5 0.0 1.6e-10 40.6 0.0 2.1 1 1 0 1 1 1 1 Male sterility protein RmlD_sub_bind PF04321.17 CAV17258.1 - 1.6e-11 43.8 0.0 2.7e-11 43.1 0.0 1.4 1 1 0 1 1 1 1 RmlD substrate binding domain adh_short PF00106.25 CAV17258.1 - 2.4e-05 23.9 0.5 0.018 14.5 0.2 2.7 2 1 0 2 2 2 2 short chain dehydrogenase KR PF08659.10 CAV17258.1 - 9.3e-05 22.4 0.0 0.00017 21.6 0.0 1.4 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.6 CAV17258.1 - 0.0093 15.9 0.0 0.015 15.2 0.0 1.4 1 0 0 1 1 1 1 NAD(P)H-binding Sacchrp_dh_NADP PF03435.18 CAV17258.1 - 0.15 12.3 0.1 0.24 11.7 0.1 1.3 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain NTP_transferase PF00483.23 CAV17259.1 - 3.1e-68 230.0 0.0 3.7e-68 229.8 0.0 1.1 1 0 0 1 1 1 1 Nucleotidyl transferase NTP_transf_3 PF12804.7 CAV17259.1 - 1.1e-14 55.1 0.0 1.3e-14 54.9 0.0 1.2 1 0 0 1 1 1 1 MobA-like NTP transferase domain IspD PF01128.19 CAV17259.1 - 0.0033 17.2 0.0 0.0058 16.4 0.0 1.3 1 0 0 1 1 1 1 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase CTP_transf_3 PF02348.19 CAV17259.1 - 0.041 13.8 0.0 0.056 13.3 0.0 1.3 1 0 0 1 1 1 0 Cytidylyltransferase dTDP_sugar_isom PF00908.17 CAV17260.1 - 3.9e-71 238.2 0.1 4.3e-71 238.0 0.1 1.0 1 0 0 1 1 1 1 dTDP-4-dehydrorhamnose 3,5-epimerase RmlD_sub_bind PF04321.17 CAV17261.1 - 4.7e-90 301.6 0.0 5.2e-90 301.4 0.0 1.0 1 0 0 1 1 1 1 RmlD substrate binding domain Epimerase PF01370.21 CAV17261.1 - 1.5e-17 63.9 0.0 1.9e-17 63.5 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 CAV17261.1 - 9.7e-14 51.5 0.0 1.3e-13 51.1 0.0 1.2 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Polysacc_synt_2 PF02719.15 CAV17261.1 - 4.1e-10 39.3 0.5 3.4e-09 36.2 0.5 2.1 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein NAD_binding_4 PF07993.12 CAV17261.1 - 7.2e-09 35.2 0.2 2e-08 33.7 0.2 1.6 1 1 0 1 1 1 1 Male sterility protein 3Beta_HSD PF01073.19 CAV17261.1 - 0.0011 18.1 0.1 0.0014 17.7 0.1 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Glycos_transf_2 PF00535.26 CAV17262.1 - 1.7e-12 47.4 0.0 2.5e-12 46.9 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 CAV17262.1 - 1.3e-09 38.3 0.0 1.6e-09 38.0 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 LPD25 PF18840.1 CAV17262.1 - 0.092 13.3 0.0 0.27 11.8 0.0 1.8 2 0 0 2 2 2 0 Large polyvalent protein associated domain 25 Epimerase PF01370.21 CAV17263.1 - 1.2e-17 64.2 0.0 1.6e-17 63.8 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 CAV17263.1 - 6.8e-16 58.1 0.0 9e-16 57.7 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family GDP_Man_Dehyd PF16363.5 CAV17263.1 - 7.4e-11 42.0 0.0 4e-10 39.6 0.0 1.9 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase NAD_binding_10 PF13460.6 CAV17263.1 - 1.6e-08 34.7 0.0 2.2e-08 34.2 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding NAD_binding_4 PF07993.12 CAV17263.1 - 8.2e-08 31.7 0.0 1.2e-07 31.2 0.0 1.2 1 0 0 1 1 1 1 Male sterility protein RmlD_sub_bind PF04321.17 CAV17263.1 - 2.4e-07 30.1 0.0 2.8e-07 29.9 0.0 1.1 1 0 0 1 1 1 1 RmlD substrate binding domain Polysacc_synt_2 PF02719.15 CAV17263.1 - 0.00042 19.5 0.3 0.0011 18.2 0.2 1.6 2 0 0 2 2 2 1 Polysaccharide biosynthesis protein Bac_transf PF02397.16 CAV17264.1 - 1.4e-48 165.0 0.2 1.6e-48 164.8 0.2 1.0 1 0 0 1 1 1 1 Bacterial sugar transferase TGF_beta_GS PF08515.12 CAV17264.1 - 0.15 11.6 0.1 0.32 10.5 0.1 1.5 1 0 0 1 1 1 0 Transforming growth factor beta type I GS-motif Polysacc_synt_2 PF02719.15 CAV17265.1 - 2.1e-128 427.6 0.1 2.9e-128 427.1 0.1 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein Epimerase PF01370.21 CAV17265.1 - 1.7e-12 47.3 0.0 1.8e-11 44.0 0.0 2.3 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family CoA_binding_3 PF13727.6 CAV17265.1 - 6.8e-09 36.0 0.1 2e-08 34.5 0.1 1.8 2 0 0 2 2 2 1 CoA-binding domain RmlD_sub_bind PF04321.17 CAV17265.1 - 7.7e-07 28.5 0.0 3.8e-06 26.2 0.0 2.0 1 1 0 1 1 1 1 RmlD substrate binding domain GDP_Man_Dehyd PF16363.5 CAV17265.1 - 2.4e-06 27.2 0.0 2.4e-05 23.9 0.0 2.0 1 1 1 2 2 2 1 GDP-mannose 4,6 dehydratase 3Beta_HSD PF01073.19 CAV17265.1 - 1e-05 24.7 0.0 1.8e-05 23.9 0.0 1.3 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family CoA_binding PF02629.19 CAV17265.1 - 5.8e-05 23.7 0.0 0.00079 20.1 0.0 2.7 3 0 0 3 3 3 1 CoA binding domain PglD_N PF17836.1 CAV17265.1 - 0.00026 21.6 0.0 0.00099 19.7 0.0 2.0 2 0 0 2 2 2 1 PglD N-terminal domain adh_short PF00106.25 CAV17265.1 - 0.003 17.0 0.0 0.0071 15.8 0.0 1.6 2 0 0 2 2 2 1 short chain dehydrogenase NAD_binding_10 PF13460.6 CAV17265.1 - 0.0072 16.2 0.0 0.12 12.2 0.0 2.7 2 1 0 2 2 2 1 NAD(P)H-binding NAD_binding_4 PF07993.12 CAV17265.1 - 0.027 13.6 0.5 0.44 9.7 0.6 2.6 1 1 1 2 2 2 0 Male sterility protein KR PF08659.10 CAV17265.1 - 0.043 13.7 0.0 0.14 12.1 0.0 1.9 2 1 0 2 2 2 0 KR domain DapB_N PF01113.20 CAV17265.1 - 0.045 13.9 0.0 3.5 7.8 0.0 2.5 2 0 0 2 2 2 0 Dihydrodipicolinate reductase, N-terminus Metalloenzyme PF01676.18 CAV17266.1 - 2.7e-82 275.9 0.1 3.1e-82 275.7 0.1 1.0 1 0 0 1 1 1 1 Metalloenzyme superfamily iPGM_N PF06415.13 CAV17266.1 - 2.7e-78 262.3 0.6 3.9e-78 261.8 0.6 1.2 1 0 0 1 1 1 1 BPG-independent PGAM N-terminus (iPGM_N) Phosphodiest PF01663.22 CAV17266.1 - 8.1e-07 28.9 0.0 1.3e-06 28.3 0.0 1.3 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.23 CAV17266.1 - 0.0031 16.9 0.0 0.0051 16.3 0.0 1.4 1 0 0 1 1 1 1 Sulfatase PGM_PMM_II PF02879.16 CAV17266.1 - 0.0046 17.6 0.2 1.8 9.3 0.0 3.3 3 0 0 3 3 3 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II Alk_phosphatase PF00245.20 CAV17266.1 - 0.018 14.0 0.0 0.034 13.1 0.0 1.4 1 0 0 1 1 1 0 Alkaline phosphatase PglZ PF08665.12 CAV17266.1 - 0.042 14.0 0.0 0.094 12.8 0.0 1.6 1 0 0 1 1 1 0 PglZ domain MatE PF01554.18 CAV17267.1 - 1.4e-50 171.1 36.7 7e-28 97.3 12.5 2.1 2 0 0 2 2 2 2 MatE Polysacc_synt_C PF14667.6 CAV17267.1 - 2.2e-07 31.1 1.2 2.2e-07 31.1 1.2 4.5 3 2 1 4 4 4 2 Polysaccharide biosynthesis C-terminal domain Wzz PF02706.15 CAV17268.1 - 8.3e-14 51.7 0.1 8.3e-14 51.7 0.1 2.9 3 0 0 3 3 3 1 Chain length determinant protein GNVR PF13807.6 CAV17268.1 - 2.2e-07 30.7 0.0 2.2e-07 30.7 0.0 1.9 2 0 0 2 2 2 1 G-rich domain on putative tyrosine kinase T-box PF00907.22 CAV17268.1 - 0.012 15.9 0.1 0.54 10.5 0.0 2.2 1 1 0 2 2 2 0 T-box Cpn10 PF00166.21 CAV17269.1 - 1.2e-28 99.0 0.3 1.3e-28 98.9 0.3 1.0 1 0 0 1 1 1 1 Chaperonin 10 Kd subunit Cpn60_TCP1 PF00118.24 CAV17270.1 - 2.8e-97 326.4 19.2 4.8e-97 325.6 19.2 1.4 1 1 0 1 1 1 1 TCP-1/cpn60 chaperonin family REF PF05755.12 CAV17270.1 - 0.07 12.9 0.6 0.21 11.4 0.2 2.0 2 0 0 2 2 2 0 Rubber elongation factor protein (REF) DUF4148 PF13663.6 CAV17271.1 - 0.076 13.2 0.5 0.1 12.8 0.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4148) GGDEF PF00990.21 CAV17272.1 - 2.5e-31 108.6 0.0 3.7e-31 108.1 0.0 1.3 1 0 0 1 1 1 1 Diguanylate cyclase, GGDEF domain dCache_1 PF02743.18 CAV17272.1 - 2.3e-08 34.1 1.3 5.2e-08 33.0 1.3 1.5 1 0 0 1 1 1 1 Cache domain MgtC PF02308.16 CAV17273.1 - 7.4e-28 97.3 12.0 8.7e-28 97.1 12.0 1.1 1 0 0 1 1 1 1 MgtC family DUF3487 PF11990.8 CAV17273.1 - 0.022 14.6 2.1 0.022 14.6 2.1 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF3487) Radical_SAM PF04055.21 CAV17274.1 - 5.3e-10 39.9 0.0 9.4e-10 39.1 0.0 1.5 1 1 0 1 1 1 1 Radical SAM superfamily Fer4_14 PF13394.6 CAV17274.1 - 5.2e-07 29.8 0.0 1e-06 28.9 0.0 1.5 1 1 0 1 1 1 1 4Fe-4S single cluster domain Fer4_12 PF13353.6 CAV17274.1 - 6.6e-07 29.7 0.0 1.4e-06 28.6 0.0 1.5 1 0 0 1 1 1 1 4Fe-4S single cluster domain EFP_N PF08207.12 CAV17275.1 - 5.6e-25 87.1 0.1 1.3e-24 86.0 0.1 1.6 1 0 0 1 1 1 1 Elongation factor P (EF-P) KOW-like domain Elong-fact-P_C PF09285.11 CAV17275.1 - 7.5e-25 86.4 1.4 1.3e-24 85.7 1.4 1.4 1 0 0 1 1 1 1 Elongation factor P, C-terminal EFP PF01132.20 CAV17275.1 - 7.5e-23 80.3 0.4 2.6e-21 75.4 0.2 2.3 2 0 0 2 2 2 1 Elongation factor P (EF-P) OB domain Fumarate_red_D PF02313.17 CAV17276.1 - 2.6e-44 150.0 5.8 3.1e-44 149.7 5.8 1.1 1 0 0 1 1 1 1 Fumarate reductase subunit D Sdh_cyt PF01127.22 CAV17276.1 - 0.034 14.2 7.1 0.091 12.8 7.2 1.6 1 1 1 2 2 2 0 Succinate dehydrogenase/Fumarate reductase transmembrane subunit Fumarate_red_C PF02300.17 CAV17277.1 - 9.6e-49 164.7 3.4 1.1e-48 164.5 3.4 1.0 1 0 0 1 1 1 1 Fumarate reductase subunit C Borrelia_P13 PF05628.12 CAV17277.1 - 0.07 13.1 1.2 0.086 12.8 1.1 1.4 1 1 0 1 1 1 0 Borrelia membrane protein P13 Fer2_3 PF13085.6 CAV17278.1 - 2.3e-33 114.4 0.0 3.9e-33 113.7 0.0 1.4 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain Fer4_8 PF13183.6 CAV17278.1 - 8.3e-11 42.2 2.3 1.9e-10 41.1 0.6 2.1 2 0 0 2 2 2 1 4Fe-4S dicluster domain Fer4_10 PF13237.6 CAV17278.1 - 6.5e-10 39.0 1.2 6.5e-10 39.0 1.2 2.2 2 0 0 2 2 2 1 4Fe-4S dicluster domain Fer4_17 PF13534.6 CAV17278.1 - 2.4e-08 34.4 11.0 1.3e-06 28.8 2.3 2.4 2 1 1 3 3 3 2 4Fe-4S dicluster domain Fer4_9 PF13187.6 CAV17278.1 - 1.2e-06 28.6 4.5 0.0017 18.5 0.6 3.1 3 0 0 3 3 3 2 4Fe-4S dicluster domain Fer4_7 PF12838.7 CAV17278.1 - 2.2e-06 28.1 1.2 2.2e-06 28.1 1.2 2.3 2 1 0 2 2 2 1 4Fe-4S dicluster domain Fer4_16 PF13484.6 CAV17278.1 - 2.4e-05 25.2 2.8 2.6e-05 25.1 0.5 2.2 2 0 0 2 2 2 1 4Fe-4S double cluster binding domain Fer4_18 PF13746.6 CAV17278.1 - 0.00023 21.4 0.5 0.31 11.2 0.1 2.5 2 0 0 2 2 2 2 4Fe-4S dicluster domain Fer4 PF00037.27 CAV17278.1 - 0.0019 18.0 3.0 0.0019 18.0 3.0 3.1 3 0 0 3 3 3 1 4Fe-4S binding domain Fer4_4 PF12800.7 CAV17278.1 - 0.0023 18.3 1.4 0.0023 18.3 1.4 3.1 3 0 0 3 3 2 1 4Fe-4S binding domain Fer4_6 PF12837.7 CAV17278.1 - 0.01 15.9 2.5 0.01 15.9 2.5 2.8 3 0 0 3 3 2 0 4Fe-4S binding domain Fer4_2 PF12797.7 CAV17278.1 - 0.018 15.1 3.2 0.018 15.1 3.2 3.4 3 0 0 3 3 3 0 4Fe-4S binding domain Fer2 PF00111.27 CAV17278.1 - 0.021 14.7 2.0 0.022 14.7 0.0 2.0 2 0 0 2 2 1 0 2Fe-2S iron-sulfur cluster binding domain Fer4_13 PF13370.6 CAV17278.1 - 0.05 14.1 1.2 0.05 14.1 1.2 2.5 2 0 0 2 2 2 0 4Fe-4S single cluster domain of Ferredoxin I Fer4_3 PF12798.7 CAV17278.1 - 0.12 13.4 3.7 0.12 13.4 3.7 2.9 3 0 0 3 3 2 0 4Fe-4S binding domain Fer4_15 PF13459.6 CAV17278.1 - 0.26 12.1 2.3 4.9 8.0 0.1 2.8 3 0 0 3 3 2 0 4Fe-4S single cluster domain Fer4_21 PF14697.6 CAV17278.1 - 2.2 8.5 15.6 0.31 11.2 8.1 2.5 2 1 0 2 2 1 0 4Fe-4S dicluster domain FAD_binding_2 PF00890.24 CAV17279.1 - 2.4e-114 382.7 1.0 3.8e-114 382.0 1.0 1.3 1 0 0 1 1 1 1 FAD binding domain Succ_DH_flav_C PF02910.20 CAV17279.1 - 1.7e-37 128.2 0.1 3e-37 127.5 0.1 1.4 1 0 0 1 1 1 1 Fumarate reductase flavoprotein C-term Pyr_redox_2 PF07992.14 CAV17279.1 - 1.5e-10 40.8 0.3 9.9e-06 25.0 0.2 3.2 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 CAV17279.1 - 5.1e-06 25.9 3.2 0.0059 15.9 0.3 3.9 5 0 0 5 5 5 1 Thi4 family HI0933_like PF03486.14 CAV17279.1 - 0.00027 19.8 0.5 0.00027 19.8 0.5 2.2 2 1 0 2 2 2 1 HI0933-like protein DAO PF01266.24 CAV17279.1 - 0.00052 19.7 0.1 0.0058 16.3 0.0 2.2 2 0 0 2 2 2 1 FAD dependent oxidoreductase Lycopene_cycl PF05834.12 CAV17279.1 - 0.0074 15.4 1.1 0.01 14.9 0.2 1.7 2 0 0 2 2 2 1 Lycopene cyclase protein GIDA PF01134.22 CAV17279.1 - 0.016 14.3 6.1 0.17 11.0 6.1 2.2 1 1 0 1 1 1 0 Glucose inhibited division protein A Myb_DNA-bind_4 PF13837.6 CAV17279.1 - 0.082 13.3 0.2 0.22 11.9 0.2 1.7 1 0 0 1 1 1 0 Myb/SANT-like DNA-binding domain FAD_oxidored PF12831.7 CAV17279.1 - 1.8 7.9 5.9 11 5.2 2.1 2.5 3 0 0 3 3 3 0 FAD dependent oxidoreductase tRNA-synt_2 PF00152.20 CAV17280.1 - 2.9e-46 158.0 0.0 6.8e-46 156.8 0.0 1.5 1 1 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA-synt_2d PF01409.20 CAV17280.1 - 0.04 13.4 0.5 9 5.7 0.0 3.0 3 1 0 3 3 3 0 tRNA synthetases class II core domain (F) EamA PF00892.20 CAV17281.1 - 1.1e-33 116.3 38.1 6.5e-18 65.2 14.0 2.0 2 0 0 2 2 2 2 EamA-like transporter family Mg_trans_NIPA PF05653.14 CAV17281.1 - 0.0043 16.2 2.8 0.0043 16.2 2.8 2.3 2 0 0 2 2 2 1 Magnesium transporter NIPA CPSF_A PF03178.15 CAV17281.1 - 0.021 14.1 0.0 0.032 13.5 0.0 1.2 1 0 0 1 1 1 0 CPSF A subunit region SLC35F PF06027.12 CAV17281.1 - 0.13 11.7 6.9 0.021 14.4 2.6 1.8 2 0 0 2 2 2 0 Solute carrier family 35 UPF0060 PF02694.15 CAV17281.1 - 3.7 7.8 11.5 0.39 11.0 3.7 3.0 2 2 0 2 2 2 0 Uncharacterised BCR, YnfA/UPF0060 family MCPsignal PF00015.21 CAV17282.1 - 1.1e-41 142.5 46.6 1.3e-41 142.3 21.7 3.3 2 1 1 3 3 3 2 Methyl-accepting chemotaxis protein (MCP) signalling domain dCache_1 PF02743.18 CAV17282.1 - 1.4e-26 93.9 6.6 1.4e-26 93.9 6.6 4.1 3 1 0 3 3 3 1 Cache domain HAMP PF00672.25 CAV17282.1 - 1.8e-10 41.0 5.3 3.6e-10 40.1 0.3 3.4 3 0 0 3 3 3 1 HAMP domain dCache_2 PF08269.11 CAV17282.1 - 1.4e-05 24.4 0.0 1.4e-05 24.4 0.0 4.1 3 1 2 5 5 5 1 Cache domain DUF948 PF06103.11 CAV17282.1 - 0.02 15.1 32.6 0.15 12.4 2.9 6.4 2 1 2 4 4 4 0 Bacterial protein of unknown function (DUF948) TnpV PF14198.6 CAV17282.1 - 0.46 10.5 4.3 2.9 7.9 0.6 2.8 2 0 0 2 2 2 0 Transposon-encoded protein TnpV BLOC1_2 PF10046.9 CAV17282.1 - 0.96 9.8 24.7 2.7 8.4 1.2 4.9 2 2 2 4 4 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 GARP PF16731.5 CAV17282.1 - 2.3 7.8 33.4 0.062 13.0 10.4 3.0 2 1 1 3 3 3 0 Glutamic acid/alanine-rich protein of Trypanosoma UPF0242 PF06785.11 CAV17282.1 - 3.9 7.5 13.6 0.57 10.3 3.9 2.5 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus Na_sulph_symp PF00939.19 CAV17283.1 - 3.7e-47 161.5 41.5 6e-47 160.8 41.5 1.3 1 0 0 1 1 1 1 Sodium:sulfate symporter transmembrane region CitMHS PF03600.16 CAV17283.1 - 2.2e-31 109.2 50.7 2.5e-31 109.0 37.8 2.2 1 1 1 2 2 2 2 Citrate transporter DctM PF06808.12 CAV17283.1 - 1.4 7.6 43.0 3.9 6.2 23.2 2.6 1 1 1 2 2 2 0 Tripartite ATP-independent periplasmic transporter, DctM component PS_Dcarbxylase PF02666.15 CAV17284.1 - 1.7e-63 213.8 0.0 2.1e-63 213.5 0.0 1.1 1 0 0 1 1 1 1 Phosphatidylserine decarboxylase RsgA_GTPase PF03193.16 CAV17285.1 - 1.1e-56 191.3 0.0 1.5e-56 190.9 0.0 1.2 1 0 0 1 1 1 1 RsgA GTPase MMR_HSR1 PF01926.23 CAV17285.1 - 0.00013 22.1 0.0 0.00027 21.0 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase Septin PF00735.18 CAV17285.1 - 0.00084 18.7 0.8 0.13 11.5 0.0 2.2 1 1 1 2 2 2 2 Septin FeoB_N PF02421.18 CAV17285.1 - 0.00095 18.7 0.2 0.43 10.1 0.2 2.3 2 0 0 2 2 2 2 Ferrous iron transport protein B MMR_HSR1_Xtn PF16897.5 CAV17285.1 - 0.0016 18.4 0.2 0.0031 17.5 0.2 1.5 1 0 0 1 1 1 1 C-terminal region of MMR_HSR1 domain ABC_tran PF00005.27 CAV17285.1 - 0.0028 18.2 0.0 0.0076 16.8 0.0 1.7 1 0 0 1 1 1 1 ABC transporter AAA_15 PF13175.6 CAV17285.1 - 0.0031 17.3 0.0 0.0054 16.5 0.0 1.3 1 0 0 1 1 1 1 AAA ATPase domain AAA_29 PF13555.6 CAV17285.1 - 0.0043 16.8 0.0 0.0095 15.7 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain cobW PF02492.19 CAV17285.1 - 0.0091 15.6 0.1 0.18 11.4 0.0 2.2 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain Ras PF00071.22 CAV17285.1 - 0.01 15.4 1.5 1.5 8.4 0.1 2.3 1 1 1 2 2 2 0 Ras family AAA_23 PF13476.6 CAV17285.1 - 0.013 16.0 0.8 0.032 14.7 0.0 2.0 2 0 0 2 2 2 0 AAA domain SMC_N PF02463.19 CAV17285.1 - 0.017 14.5 0.1 0.045 13.2 0.1 1.7 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 CAV17285.1 - 0.024 15.0 0.0 0.045 14.1 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain GTP_EFTU PF00009.27 CAV17285.1 - 0.029 13.9 0.4 0.18 11.3 0.1 2.3 1 1 1 2 2 2 0 Elongation factor Tu GTP binding domain AAA_7 PF12775.7 CAV17285.1 - 0.055 13.0 0.0 0.12 11.9 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_22 PF13401.6 CAV17285.1 - 0.083 13.2 0.0 0.19 12.0 0.0 1.6 2 0 0 2 2 2 0 AAA domain IIGP PF05049.13 CAV17285.1 - 0.086 11.9 0.3 0.19 10.7 0.2 1.6 1 1 0 1 1 1 0 Interferon-inducible GTPase (IIGP) RNase_T PF00929.24 CAV17286.1 - 8.1e-36 124.1 0.0 9.2e-36 123.9 0.0 1.0 1 0 0 1 1 1 1 Exonuclease DUF5051 PF16473.5 CAV17286.1 - 0.00012 22.1 0.0 0.00022 21.3 0.0 1.4 1 1 0 1 1 1 1 3' exoribonuclease, RNase T-like DUF1730 PF08331.10 CAV17287.1 - 8.2e-23 80.1 0.0 1.6e-22 79.2 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1730) Fer4_16 PF13484.6 CAV17287.1 - 6.4e-20 71.9 5.4 1.8e-19 70.4 5.4 1.8 1 0 0 1 1 1 1 4Fe-4S double cluster binding domain Fer4_10 PF13237.6 CAV17287.1 - 6.9e-07 29.3 1.8 0.0037 17.4 0.8 2.4 2 0 0 2 2 2 2 4Fe-4S dicluster domain Fer4_7 PF12838.7 CAV17287.1 - 2.5e-05 24.7 7.6 0.00016 22.2 7.7 2.3 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4 PF00037.27 CAV17287.1 - 0.0045 16.7 4.6 0.0045 16.7 4.6 2.9 3 0 0 3 3 3 1 4Fe-4S binding domain Fer4_3 PF12798.7 CAV17287.1 - 0.033 15.1 10.2 1.1 10.4 3.4 2.5 2 0 0 2 2 2 0 4Fe-4S binding domain Fer4_6 PF12837.7 CAV17287.1 - 0.053 13.6 15.7 0.18 11.9 4.2 2.8 2 1 0 2 2 2 0 4Fe-4S binding domain Fer4_9 PF13187.6 CAV17287.1 - 0.062 13.5 12.6 0.11 12.7 2.4 2.7 2 1 2 4 4 4 0 4Fe-4S dicluster domain Fer4_18 PF13746.6 CAV17287.1 - 0.11 12.7 7.5 0.084 13.1 2.4 2.7 3 0 0 3 3 3 0 4Fe-4S dicluster domain Fer4_8 PF13183.6 CAV17287.1 - 0.13 12.7 8.2 0.78 10.2 2.5 2.5 1 1 2 3 3 3 0 4Fe-4S dicluster domain FAST_1 PF06743.15 CAV17287.1 - 0.15 12.1 0.0 0.44 10.5 0.0 1.8 1 0 0 1 1 1 0 FAST kinase-like protein, subdomain 1 Fer4_21 PF14697.6 CAV17287.1 - 0.17 12.0 11.6 2.3 8.4 11.6 2.4 1 1 0 1 1 1 0 4Fe-4S dicluster domain Fer4_2 PF12797.7 CAV17287.1 - 1.8 8.9 13.5 10 6.5 5.3 3.1 3 0 0 3 3 3 0 4Fe-4S binding domain Fer4_22 PF17179.4 CAV17287.1 - 1.9 9.4 6.7 26 5.8 0.0 2.8 3 0 0 3 3 2 0 4Fe-4S dicluster domain TsaE PF02367.17 CAV17288.1 - 3.5e-42 143.3 0.0 4.7e-42 142.9 0.0 1.1 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_33 PF13671.6 CAV17288.1 - 0.013 15.7 0.0 0.02 15.1 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 CAV17288.1 - 0.03 14.6 0.0 0.048 13.9 0.0 1.3 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 CAV17288.1 - 0.063 13.7 0.0 0.11 12.9 0.0 1.4 1 0 0 1 1 1 0 RNA helicase NACHT PF05729.12 CAV17288.1 - 0.067 13.1 0.0 0.098 12.6 0.0 1.3 1 0 0 1 1 1 0 NACHT domain Zeta_toxin PF06414.12 CAV17288.1 - 0.13 11.5 0.1 0.3 10.3 0.1 1.5 2 0 0 2 2 2 0 Zeta toxin AAA_7 PF12775.7 CAV17288.1 - 0.14 11.7 0.1 0.2 11.1 0.1 1.2 1 0 0 1 1 1 0 P-loop containing dynein motor region Amidase_3 PF01520.18 CAV17289.1 - 9.7e-50 169.1 0.1 2.1e-49 168.0 0.1 1.6 1 0 0 1 1 1 1 N-acetylmuramoyl-L-alanine amidase LysM PF01476.20 CAV17289.1 - 9e-43 144.1 0.7 2.9e-13 49.6 0.0 4.2 4 0 0 4 4 4 3 LysM domain AMIN PF11741.8 CAV17289.1 - 3e-18 65.7 0.6 9.9e-18 64.1 0.1 2.3 2 0 0 2 2 2 1 AMIN domain Sec63 PF02889.16 CAV17289.1 - 0.013 14.7 0.1 3.6 6.7 0.0 2.7 3 0 0 3 3 3 0 Sec63 Brl domain GntR PF00392.21 CAV17289.1 - 0.014 15.0 0.0 0.32 10.7 0.0 2.9 2 1 0 2 2 2 0 Bacterial regulatory proteins, gntR family HTH_7 PF02796.15 CAV17289.1 - 0.23 11.6 2.2 10 6.3 0.2 3.5 3 0 0 3 3 3 0 Helix-turn-helix domain of resolvase DNA_mis_repair PF01119.19 CAV17290.1 - 2.7e-39 133.5 0.0 5.1e-39 132.6 0.0 1.5 1 0 0 1 1 1 1 DNA mismatch repair protein, C-terminal domain MutL_C PF08676.11 CAV17290.1 - 4.1e-23 81.8 0.1 1.3e-22 80.2 0.1 1.8 1 0 0 1 1 1 1 MutL C terminal dimerisation domain HATPase_c_3 PF13589.6 CAV17290.1 - 3.2e-12 46.5 0.0 6.2e-12 45.5 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 CAV17290.1 - 2.8e-07 31.0 0.0 7.9e-07 29.6 0.0 1.8 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DUF2856 PF11043.8 CAV17290.1 - 0.058 13.5 0.1 0.24 11.5 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2856) IPPT PF01715.17 CAV17291.1 - 1.6e-85 286.5 0.0 2e-85 286.3 0.0 1.0 1 0 0 1 1 1 1 IPP transferase IPT PF01745.16 CAV17291.1 - 2.9e-06 26.8 0.0 0.00011 21.7 0.0 2.1 2 0 0 2 2 2 1 Isopentenyl transferase AAA_33 PF13671.6 CAV17291.1 - 0.0078 16.4 0.0 0.015 15.5 0.0 1.7 1 1 0 1 1 1 1 AAA domain Hydin_ADK PF17213.3 CAV17291.1 - 0.055 13.8 0.0 0.1 12.9 0.0 1.4 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain AAA_16 PF13191.6 CAV17291.1 - 0.5 10.7 2.8 8.5 6.7 2.8 2.7 1 1 0 1 1 1 0 AAA ATPase domain Hfq PF17209.3 CAV17292.1 - 4e-31 106.5 0.2 4.9e-31 106.2 0.2 1.1 1 0 0 1 1 1 1 Hfq protein LSM PF01423.22 CAV17292.1 - 0.0026 17.4 0.0 0.0035 17.0 0.0 1.3 1 0 0 1 1 1 1 LSM domain GTP-bdg_N PF13167.6 CAV17293.1 - 3.4e-30 104.6 0.1 1.1e-29 102.9 0.0 1.9 2 0 0 2 2 2 1 GTP-binding GTPase N-terminal GTP-bdg_M PF16360.5 CAV17293.1 - 3.3e-28 98.1 13.1 3.3e-28 98.1 11.0 2.0 2 0 0 2 2 2 1 GTP-binding GTPase Middle Region MMR_HSR1 PF01926.23 CAV17293.1 - 5.7e-22 78.0 0.0 2.5e-21 75.9 0.0 2.0 2 0 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 CAV17293.1 - 6.6e-08 32.2 0.0 1.4e-07 31.2 0.0 1.6 1 1 0 1 1 1 1 Ferrous iron transport protein B Arf PF00025.21 CAV17293.1 - 9.1e-08 31.8 0.8 1.3e-06 28.0 0.8 2.3 1 1 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 CAV17293.1 - 4.6e-07 29.6 0.2 0.0013 18.3 0.1 3.0 2 1 0 2 2 2 2 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 CAV17293.1 - 7.7e-07 29.2 0.0 0.013 15.4 0.1 2.3 2 0 0 2 2 2 2 RsgA GTPase Dynamin_N PF00350.23 CAV17293.1 - 0.00015 21.8 0.4 0.52 10.3 0.1 2.4 1 1 1 2 2 2 2 Dynamin family MMR_HSR1_Xtn PF16897.5 CAV17293.1 - 0.00061 19.8 0.0 0.0015 18.5 0.0 1.7 1 0 0 1 1 1 1 C-terminal region of MMR_HSR1 domain cobW PF02492.19 CAV17293.1 - 0.0033 17.0 2.2 0.093 12.3 0.3 2.4 1 1 1 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain G-alpha PF00503.20 CAV17293.1 - 0.0061 15.8 0.1 1.6 7.8 0.0 2.9 2 1 1 3 3 3 1 G-protein alpha subunit Roc PF08477.13 CAV17293.1 - 0.0071 16.6 0.1 3.6 7.8 0.0 2.3 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase MnmE_helical PF12631.7 CAV17293.1 - 0.0078 16.4 0.1 0.014 15.6 0.1 1.3 1 0 0 1 1 1 1 MnmE helical domain Gtr1_RagA PF04670.12 CAV17293.1 - 0.011 15.1 0.0 0.018 14.4 0.0 1.3 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region Ras PF00071.22 CAV17293.1 - 0.025 14.2 0.0 0.16 11.5 0.0 2.1 1 1 0 1 1 1 0 Ras family SRPRB PF09439.10 CAV17293.1 - 0.027 13.9 0.2 0.082 12.3 0.2 1.8 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit ABC_tran PF00005.27 CAV17293.1 - 0.053 14.0 0.1 0.56 10.7 0.0 2.6 3 1 0 3 3 3 0 ABC transporter TniB PF05621.11 CAV17293.1 - 0.066 12.6 0.0 0.15 11.5 0.0 1.7 1 0 0 1 1 1 0 Bacterial TniB protein EFG_C PF00679.24 CAV17293.1 - 0.092 12.8 0.3 2.4 8.2 0.0 2.3 2 0 0 2 2 2 0 Elongation factor G C-terminus Band_7 PF01145.25 CAV17294.1 - 3.7e-27 95.5 2.2 5.1e-27 95.0 2.2 1.2 1 0 0 1 1 1 1 SPFH domain / Band 7 family HflK_N PF12221.8 CAV17294.1 - 7.5e-13 48.3 18.9 2.2e-12 46.8 18.9 1.9 1 1 0 1 1 1 1 Bacterial membrane protein N terminal Band_7 PF01145.25 CAV17295.1 - 2.2e-27 96.2 1.8 3.6e-27 95.5 1.0 1.8 1 1 1 2 2 2 1 SPFH domain / Band 7 family Band_7_1 PF13421.6 CAV17295.1 - 0.0094 15.7 0.1 0.017 14.8 0.1 1.6 1 1 0 1 1 1 1 SPFH domain-Band 7 family DUF1598 PF07643.11 CAV17295.1 - 0.096 12.9 1.1 10 6.4 0.2 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF1598) DUF2065 PF09838.9 CAV17296.1 - 3.5e-23 81.4 2.4 4.2e-23 81.1 2.4 1.1 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2065) DUF3185 PF11381.8 CAV17296.1 - 0.31 11.1 5.8 1.4 9.0 0.2 2.3 2 1 1 3 3 2 0 Protein of unknown function (DUF3185) Adenylsucc_synt PF00709.21 CAV17297.1 - 9.6e-179 594.7 0.0 1.1e-178 594.5 0.0 1.0 1 0 0 1 1 1 1 Adenylosuccinate synthetase Sel1 PF08238.12 CAV17298.1 - 4.4e-11 43.1 4.5 2.8e-05 24.6 0.1 3.2 3 0 0 3 3 3 2 Sel1 repeat Amidohydro_1 PF01979.20 CAV17299.1 - 9.1e-69 232.4 3.4 1.2e-68 232.0 3.4 1.1 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 CAV17299.1 - 7.4e-15 55.4 10.6 1.5e-11 44.5 0.1 3.8 4 1 0 4 4 4 2 Amidohydrolase family TatD_DNase PF01026.21 CAV17299.1 - 0.084 12.2 0.0 0.2 11.0 0.0 1.7 1 0 0 1 1 1 0 TatD related DNase RNB PF00773.19 CAV17300.1 - 2.3e-108 362.4 0.0 3.1e-108 362.0 0.0 1.2 1 0 0 1 1 1 1 RNB domain CSD2 PF17876.1 CAV17300.1 - 7.6e-30 102.9 0.5 3.8e-24 84.7 0.1 2.7 2 0 0 2 2 2 2 Cold shock domain OB_RNB PF08206.11 CAV17300.1 - 1.2e-21 76.1 0.4 1.2e-21 76.1 0.4 3.6 4 0 0 4 4 4 1 Ribonuclease B OB domain S1 PF00575.23 CAV17300.1 - 3.4e-14 52.9 0.2 7.7e-14 51.8 0.2 1.7 1 0 0 1 1 1 1 S1 RNA binding domain HTH_12 PF08461.10 CAV17300.1 - 5.1e-10 39.2 0.1 1.5e-09 37.6 0.1 1.9 1 0 0 1 1 1 1 Ribonuclease R winged-helix domain eIF-1a PF01176.19 CAV17300.1 - 0.034 13.9 1.1 2.2 8.1 0.0 3.7 5 0 0 5 5 5 0 Translation initiation factor 1A / IF-1 RNase_II_C_S1 PF18614.1 CAV17300.1 - 0.073 13.0 0.0 0.64 10.0 0.0 2.5 2 0 0 2 2 2 0 RNase II-type exonuclease C-terminal S1 domain Peptidase_S24 PF00717.23 CAV17300.1 - 0.085 12.8 0.0 0.3 11.1 0.0 2.0 1 0 0 1 1 1 0 Peptidase S24-like RNA_pol_Rbc25 PF08292.12 CAV17300.1 - 0.1 12.8 1.1 0.14 12.4 0.0 1.8 2 0 0 2 2 2 0 RNA polymerase III subunit Rpc25 SRP-alpha_N PF04086.13 CAV17300.1 - 1.4 8.8 11.1 2 8.2 11.1 1.2 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal SpoU_methylase PF00588.19 CAV17301.1 - 7.4e-39 133.2 0.0 1e-38 132.7 0.0 1.2 1 0 0 1 1 1 1 SpoU rRNA Methylase family SpoU_sub_bind PF08032.12 CAV17301.1 - 1.3e-18 67.0 0.0 8.7e-18 64.4 0.1 2.0 2 0 0 2 2 2 1 RNA 2'-O ribose methyltransferase substrate binding Ribosomal_S6 PF01250.17 CAV17302.1 - 2.4e-27 95.1 0.1 3.2e-27 94.6 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein S6 Ribosomal_S18 PF01084.20 CAV17303.1 - 2.4e-25 88.5 0.3 3.2e-25 88.1 0.3 1.2 1 0 0 1 1 1 1 Ribosomal protein S18 Ribosomal_L9_C PF03948.14 CAV17304.1 - 2.4e-23 82.4 0.5 3.9e-23 81.7 0.5 1.4 1 0 0 1 1 1 1 Ribosomal protein L9, C-terminal domain Ribosomal_L9_N PF01281.19 CAV17304.1 - 3.1e-21 74.6 0.5 5.9e-21 73.8 0.5 1.5 1 0 0 1 1 1 1 Ribosomal protein L9, N-terminal domain DUF481 PF04338.12 CAV17305.1 - 2.1e-52 178.2 6.5 2.5e-52 178.0 6.5 1.1 1 0 0 1 1 1 1 Protein of unknown function, DUF481 Porin_4 PF13609.6 CAV17305.1 - 0.00026 20.8 3.5 0.00026 20.8 3.5 1.4 1 1 0 1 1 1 1 Gram-negative porin DUF3575 PF12099.8 CAV17305.1 - 0.16 11.2 0.7 1.3 8.3 0.7 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF3575) OMP_b-brl PF13505.6 CAV17305.1 - 0.21 11.7 5.4 0.36 10.9 4.0 1.8 1 1 1 2 2 2 0 Outer membrane protein beta-barrel domain DnaB_C PF03796.15 CAV17306.1 - 2.8e-112 374.2 1.0 3.6e-112 373.8 1.0 1.1 1 0 0 1 1 1 1 DnaB-like helicase C terminal domain DnaB PF00772.21 CAV17306.1 - 1.9e-35 121.0 0.0 3.6e-35 120.1 0.0 1.5 1 0 0 1 1 1 1 DnaB-like helicase N terminal domain AAA_25 PF13481.6 CAV17306.1 - 2.2e-11 43.7 0.0 3.5e-11 43.1 0.0 1.2 1 0 0 1 1 1 1 AAA domain ATPase PF06745.13 CAV17306.1 - 5.1e-05 22.7 0.0 0.00015 21.2 0.0 1.7 1 1 0 1 1 1 1 KaiC AAA_33 PF13671.6 CAV17306.1 - 0.021 15.0 0.0 0.18 12.0 0.0 2.2 2 0 0 2 2 2 0 AAA domain HSCB_C PF07743.13 CAV17306.1 - 0.12 12.9 0.3 2.6 8.6 0.0 3.0 3 0 0 3 3 3 0 HSCB C-terminal oligomerisation domain EzrA PF06160.12 CAV17306.1 - 0.13 10.4 0.3 0.19 9.8 0.3 1.2 1 0 0 1 1 1 0 Septation ring formation regulator, EzrA Ala_racemase_N PF01168.20 CAV17307.1 - 4.3e-67 226.0 0.0 5.2e-67 225.7 0.0 1.1 1 0 0 1 1 1 1 Alanine racemase, N-terminal domain Ala_racemase_C PF00842.21 CAV17307.1 - 2.1e-42 143.9 0.1 3.9e-42 143.0 0.1 1.5 1 0 0 1 1 1 1 Alanine racemase, C-terminal domain Bac_surface_Ag PF01103.23 CAV17308.1 - 1.5e-05 24.7 2.9 3e-05 23.7 2.9 1.5 1 1 0 1 1 1 1 Surface antigen UPF0047 PF01894.17 CAV17309.1 - 5.5e-40 136.1 0.0 6.4e-40 135.9 0.0 1.0 1 0 0 1 1 1 1 Uncharacterised protein family UPF0047 PGI PF00342.19 CAV17310.1 - 2.2e-251 834.6 1.1 2.6e-251 834.4 1.1 1.0 1 0 0 1 1 1 1 Phosphoglucose isomerase CheX PF13690.6 CAV17311.1 - 6.6e-22 77.5 0.5 9e-22 77.1 0.5 1.2 1 0 0 1 1 1 1 Chemotaxis phosphatase CheX CheC PF04509.12 CAV17311.1 - 6.3e-11 42.0 0.2 1.2e-10 41.1 0.2 1.5 1 0 0 1 1 1 1 CheC-like family FUR PF01475.19 CAV17312.1 - 1.9e-19 70.0 0.0 2.6e-19 69.6 0.0 1.3 1 0 0 1 1 1 1 Ferric uptake regulator family TrmB PF01978.19 CAV17312.1 - 0.00012 21.9 0.0 0.00028 20.7 0.0 1.6 1 1 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB PadR PF03551.14 CAV17312.1 - 0.00075 19.4 0.0 0.033 14.2 0.0 2.2 2 0 0 2 2 2 1 Transcriptional regulator PadR-like family HTH_11 PF08279.12 CAV17312.1 - 0.0063 16.4 0.0 0.022 14.7 0.0 1.8 1 1 0 1 1 1 1 HTH domain MarR PF01047.22 CAV17312.1 - 0.0078 16.1 0.0 0.024 14.6 0.0 1.8 1 1 0 1 1 1 1 MarR family Penicillinase_R PF03965.16 CAV17312.1 - 0.059 13.7 0.0 0.067 13.5 0.0 1.2 1 0 0 1 1 1 0 Penicillinase repressor RdRP_5 PF07925.11 CAV17312.1 - 0.092 10.1 0.0 0.093 10.1 0.0 1.0 1 0 0 1 1 1 0 Reovirus RNA-dependent RNA polymerase lambda 3 Dimerisation PF08100.11 CAV17312.1 - 0.1 12.6 0.0 0.17 12.0 0.0 1.4 1 0 0 1 1 1 0 Dimerisation domain Arc_trans_TRASH PF08394.10 CAV17312.1 - 1.7 9.0 9.6 32 5.0 0.2 3.3 3 0 0 3 3 3 0 Archaeal TRASH domain Phage_lambda_P PF06992.11 CAV17315.1 - 0.14 11.9 0.0 0.19 11.5 0.0 1.2 1 0 0 1 1 1 0 Replication protein P Dus PF01207.17 CAV17316.1 - 1.5e-92 310.0 0.0 1.8e-92 309.7 0.0 1.0 1 0 0 1 1 1 1 Dihydrouridine synthase (Dus) PcrB PF01884.17 CAV17316.1 - 0.076 12.5 0.0 0.14 11.6 0.0 1.4 1 0 0 1 1 1 0 PcrB family Phageshock_PspG PF09583.10 CAV17318.1 - 2.2e-25 88.7 23.0 2.5e-25 88.5 23.0 1.0 1 0 0 1 1 1 1 Phage shock protein G (Phageshock_PspG) Amastin PF07344.11 CAV17318.1 - 0.074 12.9 6.7 0.074 12.9 6.7 1.1 1 0 0 1 1 1 0 Amastin surface glycoprotein Rax2 PF12768.7 CAV17318.1 - 1.4 8.3 4.7 2 7.8 4.7 1.2 1 0 0 1 1 1 0 Cortical protein marker for cell polarity ABC2_membrane_4 PF12730.7 CAV17318.1 - 2 8.4 13.5 2.2 8.2 13.5 1.0 1 0 0 1 1 1 0 ABC-2 family transporter protein DUF3005 PF11448.8 CAV17319.1 - 0.15 12.1 0.0 0.26 11.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3005) Flavodoxin_1 PF00258.25 CAV17321.1 - 1.7e-30 106.1 0.9 1.7e-29 102.9 0.5 2.7 3 0 0 3 3 3 1 Flavodoxin FAD_binding_1 PF00667.20 CAV17321.1 - 8.4e-27 94.2 0.1 2.9e-26 92.4 0.1 1.8 1 1 0 1 1 1 1 FAD binding domain NAD_binding_1 PF00175.21 CAV17321.1 - 1.5e-21 77.1 0.0 2.9e-20 73.0 0.0 2.5 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain Flavodoxin_5 PF12724.7 CAV17321.1 - 0.00059 20.1 0.0 0.0023 18.2 0.0 2.1 2 0 0 2 2 2 1 Flavodoxin domain Flavodoxin_3 PF12641.7 CAV17321.1 - 0.0017 18.0 0.2 0.0044 16.7 0.0 1.8 2 0 0 2 2 2 1 Flavodoxin domain Flavodoxin_NdrI PF07972.11 CAV17321.1 - 0.0027 17.8 0.0 0.0098 16.1 0.0 2.0 1 0 0 1 1 1 1 NrdI Flavodoxin like RVT_3 PF13456.6 CAV17321.1 - 0.07 12.9 0.3 12 5.7 0.2 2.8 2 0 0 2 2 2 0 Reverse transcriptase-like ZnuA PF01297.17 CAV17321.1 - 0.11 11.9 1.5 0.54 9.6 0.3 2.3 2 0 0 2 2 2 0 Zinc-uptake complex component A periplasmic DUF5340 PF17275.2 CAV17321.1 - 0.13 12.4 0.2 0.45 10.7 0.2 1.9 1 0 0 1 1 1 0 Family of unknown function (DUF5340) NIR_SIR PF01077.22 CAV17322.1 - 5.8e-53 178.6 0.1 1.4e-46 157.9 0.1 2.2 2 0 0 2 2 2 2 Nitrite and sulphite reductase 4Fe-4S domain NIR_SIR_ferr PF03460.17 CAV17322.1 - 3.1e-29 100.6 0.1 5.3e-14 51.8 0.0 2.9 2 0 0 2 2 2 2 Nitrite/Sulfite reductase ferredoxin-like half domain PAPS_reduct PF01507.19 CAV17323.1 - 7.3e-49 166.1 0.0 9.7e-49 165.7 0.0 1.2 1 0 0 1 1 1 1 Phosphoadenosine phosphosulfate reductase family YceG PF02618.16 CAV17323.1 - 0.067 12.8 0.0 0.088 12.4 0.0 1.2 1 0 0 1 1 1 0 YceG-like family Cys_Met_Meta_PP PF01053.20 CAV17323.1 - 0.084 11.4 0.0 0.12 10.9 0.0 1.1 1 0 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme Na_H_Exchanger PF00999.21 CAV17324.1 - 2.5e-54 184.5 36.5 4.2e-54 183.8 36.2 1.5 1 1 1 2 2 2 1 Sodium/hydrogen exchanger family Myco_arth_vir_N PF09610.10 CAV17324.1 - 1.1 9.4 0.0 1.1 9.4 0.0 3.3 3 1 1 4 4 4 0 Mycoplasma virulence signal region (Myco_arth_vir_N) Met_synt_B12 PF02965.17 CAV17325.1 - 1.6e-125 418.1 0.0 2.6e-125 417.4 0.0 1.4 1 0 0 1 1 1 1 Vitamin B12 dependent methionine synthase, activation domain S-methyl_trans PF02574.16 CAV17325.1 - 2e-82 277.0 0.0 5.5e-82 275.6 0.0 1.8 2 0 0 2 2 2 1 Homocysteine S-methyltransferase Pterin_bind PF00809.22 CAV17325.1 - 3.9e-59 200.3 0.5 2.2e-58 197.8 0.4 2.3 2 0 0 2 2 2 1 Pterin binding enzyme B12-binding_2 PF02607.17 CAV17325.1 - 8e-25 87.1 2.0 1.4e-24 86.3 0.1 2.5 2 0 0 2 2 2 1 B12 binding domain B12-binding PF02310.19 CAV17325.1 - 2e-18 66.6 0.1 5.8e-18 65.1 0.1 1.8 1 0 0 1 1 1 1 B12 binding domain AA_kinase PF00696.28 CAV17326.1 - 2.6e-46 158.2 0.6 7.6e-46 156.6 0.3 1.8 2 0 0 2 2 2 1 Amino acid kinase family ACT PF01842.25 CAV17326.1 - 2.7e-05 23.9 0.0 0.00039 20.1 0.0 2.7 2 1 0 2 2 2 1 ACT domain ACT_7 PF13840.6 CAV17326.1 - 0.00099 18.9 0.0 0.0062 16.3 0.0 2.4 2 0 0 2 2 2 1 ACT domain DUF4527 PF15030.6 CAV17326.1 - 0.025 14.0 0.4 0.043 13.3 0.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4527) PRD1_DD PF11087.8 CAV17326.1 - 0.14 11.9 1.1 0.4 10.4 1.1 1.9 1 0 0 1 1 1 0 PRD1 phage membrane DNA delivery Aminotran_5 PF00266.19 CAV17327.1 - 9.7e-33 113.6 0.0 1.1e-32 113.4 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-V Cys_Met_Meta_PP PF01053.20 CAV17327.1 - 0.0038 15.8 0.0 0.0051 15.4 0.0 1.1 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme DegT_DnrJ_EryC1 PF01041.17 CAV17327.1 - 0.0047 16.3 0.2 0.008 15.5 0.2 1.3 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Peripla_BP_4 PF13407.6 CAV17327.1 - 0.024 14.2 0.2 0.05 13.2 0.2 1.5 1 0 0 1 1 1 0 Periplasmic binding protein domain Complex1_49kDa PF00346.19 CAV17327.1 - 0.17 11.0 0.0 0.24 10.5 0.0 1.2 1 0 0 1 1 1 0 Respiratory-chain NADH dehydrogenase, 49 Kd subunit Wzy_C_2 PF11846.8 CAV17328.1 - 2e-66 223.5 0.7 2e-66 223.5 0.7 3.4 3 1 1 4 4 4 1 Virulence factor membrane-bound polymerase, C-terminal Wzy_C PF04932.15 CAV17328.1 - 6.2e-18 64.9 0.2 6.2e-18 64.9 0.2 4.4 2 2 1 3 3 3 1 O-Antigen ligase PglL_A PF15864.5 CAV17328.1 - 1.1e-10 41.1 2.1 1.3e-09 37.6 0.9 3.3 2 0 0 2 2 2 1 Protein glycosylation ligase DUF2484 PF10658.9 CAV17328.1 - 0.011 16.0 0.6 0.011 16.0 0.6 3.6 3 2 1 4 4 4 0 Protein of unknown function (DUF2484) EpsG PF14897.6 CAV17328.1 - 0.97 8.7 31.5 0.017 14.4 12.9 3.5 2 2 1 3 3 3 0 EpsG family UvrA_inter PF17760.1 CAV17329.1 - 3.4e-36 123.6 0.0 9.2e-36 122.2 0.0 1.8 1 0 0 1 1 1 1 UvrA interaction domain UvrA_DNA-bind PF17755.1 CAV17329.1 - 8.2e-35 119.5 0.1 1.7e-33 115.3 0.0 2.8 2 0 0 2 2 2 1 UvrA DNA-binding domain ABC_tran PF00005.27 CAV17329.1 - 8.4e-22 78.2 0.3 1e-09 39.0 0.1 4.8 3 2 0 3 3 3 3 ABC transporter SMC_N PF02463.19 CAV17329.1 - 3e-10 39.9 0.1 0.15 11.5 0.0 4.1 4 0 0 4 4 4 3 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 CAV17329.1 - 1.1e-07 31.5 0.7 0.01 15.5 0.2 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_16 PF13191.6 CAV17329.1 - 1.4e-06 28.8 0.5 0.073 13.5 0.0 3.5 4 0 0 4 4 3 2 AAA ATPase domain RsgA_GTPase PF03193.16 CAV17329.1 - 4.7e-06 26.6 0.2 0.048 13.6 0.1 2.4 2 0 0 2 2 2 2 RsgA GTPase AAA_23 PF13476.6 CAV17329.1 - 1.5e-05 25.6 6.4 0.0029 18.1 0.2 3.1 3 0 0 3 3 3 2 AAA domain AAA_22 PF13401.6 CAV17329.1 - 0.00043 20.6 0.6 1.9 8.7 0.0 3.2 3 0 0 3 3 3 2 AAA domain DnaJ_CXXCXGXG PF00684.19 CAV17329.1 - 0.00098 19.4 6.8 0.048 14.0 0.2 3.7 3 1 0 3 3 3 1 DnaJ central domain AAA_30 PF13604.6 CAV17329.1 - 0.0013 18.5 0.3 2.9 7.6 0.1 3.4 3 0 0 3 3 3 1 AAA domain AAA_25 PF13481.6 CAV17329.1 - 0.0032 17.1 4.1 0.39 10.3 0.0 3.1 3 0 0 3 3 3 2 AAA domain DUF2075 PF09848.9 CAV17329.1 - 0.0043 16.4 0.1 2.2 7.4 0.1 2.3 2 0 0 2 2 2 2 Uncharacterized conserved protein (DUF2075) NACHT PF05729.12 CAV17329.1 - 0.0045 16.9 0.0 0.35 10.8 0.0 2.4 2 0 0 2 2 2 1 NACHT domain AAA_18 PF13238.6 CAV17329.1 - 0.0052 17.3 0.2 3.2 8.3 0.2 2.7 2 0 0 2 2 2 1 AAA domain MMR_HSR1 PF01926.23 CAV17329.1 - 0.0057 16.7 0.1 0.22 11.6 0.1 2.7 2 0 0 2 2 2 1 50S ribosome-binding GTPase cobW PF02492.19 CAV17329.1 - 0.0062 16.2 1.1 0.78 9.3 0.2 2.6 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain AAA_14 PF13173.6 CAV17329.1 - 0.008 16.2 0.0 15 5.6 0.0 3.4 3 0 0 3 3 3 0 AAA domain AAA_21 PF13304.6 CAV17329.1 - 0.0087 15.9 8.6 0.55 10.0 0.1 4.1 4 0 0 4 4 4 1 AAA domain, putative AbiEii toxin, Type IV TA system Viral_helicase1 PF01443.18 CAV17329.1 - 0.012 15.3 0.1 0.4 10.4 0.1 2.5 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase AAA_33 PF13671.6 CAV17329.1 - 0.012 15.7 0.1 6.7 6.9 0.0 2.8 2 0 0 2 2 2 0 AAA domain APS_kinase PF01583.20 CAV17329.1 - 0.014 15.3 0.3 3.2 7.6 0.0 2.7 2 0 0 2 2 2 0 Adenylylsulphate kinase MccV PF17508.2 CAV17329.1 - 0.023 15.3 0.1 14 6.3 0.2 3.1 3 0 0 3 3 3 0 Microcin V bacteriocin ATPase PF06745.13 CAV17329.1 - 0.03 13.7 0.1 4.6 6.5 0.0 2.4 2 0 0 2 2 2 0 KaiC BCA_ABC_TP_C PF12399.8 CAV17329.1 - 0.031 14.2 2.1 4.7 7.3 0.4 2.7 2 0 0 2 2 2 0 Branched-chain amino acid ATP-binding cassette transporter zf_C2H2_10 PF18414.1 CAV17329.1 - 0.11 12.1 0.2 0.26 10.8 0.2 1.7 1 0 0 1 1 1 0 C2H2 type zinc-finger ATPase_2 PF01637.18 CAV17329.1 - 0.12 12.2 0.0 10 5.9 0.0 2.5 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea AAA_24 PF13479.6 CAV17329.1 - 0.12 12.0 0.7 5.7 6.6 0.0 3.0 3 0 0 3 3 3 0 AAA domain AAA_7 PF12775.7 CAV17329.1 - 0.21 11.1 0.1 18 4.8 0.1 2.5 2 0 0 2 2 2 0 P-loop containing dynein motor region NTPase_1 PF03266.15 CAV17329.1 - 0.39 10.6 2.7 2.5 8.0 0.1 3.2 3 0 0 3 3 3 0 NTPase NTP_transferase PF00483.23 CAV17330.1 - 6.5e-32 111.1 0.0 9.5e-32 110.5 0.0 1.1 1 0 0 1 1 1 1 Nucleotidyl transferase NTP_transf_3 PF12804.7 CAV17330.1 - 2.6e-07 31.1 0.0 4.4e-07 30.4 0.0 1.3 1 0 0 1 1 1 1 MobA-like NTP transferase domain Glycos_transf_2 PF00535.26 CAV17330.1 - 0.045 13.6 0.0 0.07 12.9 0.0 1.3 1 0 0 1 1 1 0 Glycosyl transferase family 2 GerE PF00196.19 CAV17331.1 - 2.2e-19 68.7 0.0 4e-19 67.9 0.0 1.4 1 0 0 1 1 1 1 Bacterial regulatory proteins, luxR family Sigma70_r4_2 PF08281.12 CAV17331.1 - 0.0068 16.1 0.0 0.015 14.9 0.0 1.6 1 0 0 1 1 1 1 Sigma-70, region 4 SSB PF00436.25 CAV17332.1 - 2.4e-43 146.4 0.6 3.4e-43 145.9 0.6 1.2 1 0 0 1 1 1 1 Single-strand binding protein family TFIIA PF03153.13 CAV17332.1 - 0.23 11.4 13.6 0.26 11.2 13.6 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Pex14_N PF04695.13 CAV17332.1 - 0.62 10.7 9.3 0.84 10.3 9.3 1.3 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Spt20 PF12090.8 CAV17332.1 - 3.1 7.4 13.9 4.1 7.0 13.9 1.3 1 0 0 1 1 1 0 Spt20 family Androgen_recep PF02166.16 CAV17332.1 - 8.1 5.2 24.1 11 4.7 24.1 1.1 1 0 0 1 1 1 0 Androgen receptor EAL PF00563.20 CAV17333.1 - 1.5e-43 149.0 0.0 2.3e-43 148.4 0.0 1.3 1 0 0 1 1 1 1 EAL domain GAPES4 PF17157.4 CAV17333.1 - 1.4e-26 92.7 0.0 3.1e-26 91.6 0.0 1.6 1 0 0 1 1 1 1 Gammaproteobacterial periplasmic sensor domain GGDEF PF00990.21 CAV17333.1 - 9.9e-19 67.6 0.0 2.1e-18 66.6 0.0 1.6 1 0 0 1 1 1 1 Diguanylate cyclase, GGDEF domain DivIC PF04977.15 CAV17334.1 - 0.0019 17.9 0.1 0.0056 16.4 0.1 1.8 2 0 0 2 2 2 1 Septum formation initiator Seryl_tRNA_N PF02403.22 CAV17334.1 - 0.011 15.9 1.0 0.029 14.6 1.0 1.7 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain DUF1451 PF07295.11 CAV17334.1 - 0.017 15.2 0.0 0.11 12.5 0.0 2.2 2 0 0 2 2 2 0 Zinc-ribbon containing domain LRRFIP PF09738.9 CAV17334.1 - 0.048 13.1 0.3 0.09 12.2 0.3 1.4 1 0 0 1 1 1 0 LRRFIP family Spc24 PF08286.11 CAV17334.1 - 1.6 9.0 4.6 0.7 10.2 0.5 2.3 2 0 0 2 2 2 0 Spc24 subunit of Ndc80 LPP PF04728.13 CAV17334.1 - 2.2 8.7 6.6 3.4 8.1 3.2 3.0 2 1 0 2 2 2 0 Lipoprotein leucine-zipper PilO PF04350.13 CAV17335.1 - 3.4e-07 30.5 1.6 6.4e-07 29.6 1.5 1.5 1 1 0 1 1 1 1 Pilus assembly protein, PilO T2SSM PF04612.12 CAV17335.1 - 0.0001 22.4 0.1 0.00014 22.0 0.1 1.4 1 1 0 1 1 1 1 Type II secretion system (T2SS), protein M 60KD_IMP PF02096.20 CAV17335.1 - 0.021 14.7 0.3 0.032 14.1 0.3 1.3 1 0 0 1 1 1 0 60Kd inner membrane protein XPA_N PF01286.18 CAV17335.1 - 0.14 12.2 0.1 0.33 11.0 0.1 1.6 1 0 0 1 1 1 0 XPA protein N-terminal T2SSB PF16537.5 CAV17336.1 - 0.0018 17.9 0.0 0.0026 17.3 0.0 1.2 1 0 0 1 1 1 1 Type II secretion system protein B DUF4261 PF14080.6 CAV17336.1 - 0.14 12.3 0.0 0.21 11.7 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4261) Secretin PF00263.21 CAV17337.1 - 2e-41 141.4 1.0 2e-41 141.4 1.0 1.8 2 0 0 2 2 2 1 Bacterial type II and III secretion system protein Secretin_N_2 PF07655.13 CAV17337.1 - 2.6e-26 92.0 11.7 8.1e-26 90.4 11.7 1.9 1 0 0 1 1 1 1 Secretin N-terminal domain STN PF07660.14 CAV17337.1 - 7.1e-05 22.5 0.0 0.001 18.8 0.0 2.6 1 1 1 2 2 2 1 Secretin and TonB N terminus short domain DUF515 PF04415.12 CAV17337.1 - 0.012 14.1 5.6 0.021 13.2 5.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF515) DUF763 PF05559.11 CAV17337.1 - 0.087 12.0 0.0 0.2 10.8 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF763) HTH_19 PF12844.7 CAV17337.1 - 0.14 12.2 0.4 0.31 11.1 0.4 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain AAA_22 PF13401.6 CAV17338.1 - 5.2e-25 88.3 0.9 7.8e-25 87.7 0.3 1.5 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 CAV17338.1 - 1.6e-06 28.6 1.5 0.00025 21.4 1.5 2.4 1 1 0 1 1 1 1 AAA ATPase domain AAA_30 PF13604.6 CAV17338.1 - 8.3e-05 22.4 0.2 0.00012 21.8 0.2 1.2 1 0 0 1 1 1 1 AAA domain DUF2075 PF09848.9 CAV17338.1 - 0.00024 20.5 0.0 0.00035 19.9 0.0 1.3 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) ATPase_2 PF01637.18 CAV17338.1 - 0.00038 20.4 0.1 0.051 13.5 0.1 2.3 1 1 0 1 1 1 1 ATPase domain predominantly from Archaea AAA PF00004.29 CAV17338.1 - 0.0014 19.1 0.0 0.0022 18.4 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Sigma54_activ_2 PF14532.6 CAV17338.1 - 0.0019 18.3 0.1 0.0041 17.2 0.1 1.6 1 1 0 1 1 1 1 Sigma-54 interaction domain APS_kinase PF01583.20 CAV17338.1 - 0.0037 17.2 0.1 0.0059 16.5 0.1 1.2 1 0 0 1 1 1 1 Adenylylsulphate kinase AAA_7 PF12775.7 CAV17338.1 - 0.0073 15.8 0.1 0.021 14.4 0.0 1.7 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_19 PF13245.6 CAV17338.1 - 0.0089 16.4 2.3 0.14 12.5 2.3 2.3 1 1 0 1 1 1 1 AAA domain DEAD PF00270.29 CAV17338.1 - 0.011 15.5 2.3 1.1 9.0 0.1 2.2 1 1 1 2 2 2 0 DEAD/DEAH box helicase AAA_lid_3 PF17862.1 CAV17338.1 - 0.02 14.7 0.3 0.49 10.3 0.1 2.4 2 0 0 2 2 2 0 AAA+ lid domain TsaE PF02367.17 CAV17338.1 - 0.028 14.4 0.0 0.055 13.5 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE PIF1 PF05970.14 CAV17338.1 - 0.035 13.3 0.1 0.064 12.4 0.1 1.4 1 1 0 1 1 1 0 PIF1-like helicase PhoH PF02562.16 CAV17338.1 - 0.043 13.3 0.1 1.2 8.5 0.0 2.3 2 0 0 2 2 2 0 PhoH-like protein AAA_5 PF07728.14 CAV17338.1 - 0.051 13.6 0.1 0.098 12.7 0.1 1.4 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_18 PF13238.6 CAV17338.1 - 0.094 13.3 0.0 0.14 12.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 CAV17338.1 - 0.11 13.0 0.0 0.19 12.2 0.0 1.4 1 1 0 1 1 1 0 ABC transporter TPR_19 PF14559.6 CAV17339.1 - 1.6e-09 38.1 5.7 0.0001 22.8 0.1 3.6 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_11 PF13414.6 CAV17339.1 - 1.2e-08 34.4 0.3 0.00082 19.0 0.1 3.0 2 1 0 2 2 2 2 TPR repeat TPR_2 PF07719.17 CAV17339.1 - 3.5e-06 26.7 7.1 0.41 10.9 0.0 4.4 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_15 PF13429.6 CAV17339.1 - 6.8e-06 25.5 3.0 0.0016 17.7 0.6 2.7 1 1 2 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.6 CAV17339.1 - 4.7e-05 24.0 3.4 0.082 13.6 0.1 3.2 2 1 0 2 2 2 2 Tetratricopeptide repeat TPR_14 PF13428.6 CAV17339.1 - 0.00011 22.7 1.3 0.68 10.9 0.0 3.7 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_17 PF13431.6 CAV17339.1 - 0.0006 20.0 0.7 0.049 14.0 0.0 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_1 PF00515.28 CAV17339.1 - 0.0024 17.6 5.2 0.24 11.3 0.0 4.1 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_20 PF14561.6 CAV17339.1 - 0.0094 16.3 0.1 2.6 8.4 0.0 2.9 1 1 1 2 2 2 1 Tetratricopeptide repeat ANAPC3 PF12895.7 CAV17339.1 - 0.016 15.4 0.3 0.083 13.1 0.1 2.2 1 1 2 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_8 PF13181.6 CAV17339.1 - 0.019 15.1 2.8 3.6 8.0 0.1 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat NARP1 PF12569.8 CAV17339.1 - 0.029 13.3 0.4 0.44 9.4 0.4 2.0 1 1 1 2 2 2 0 NMDA receptor-regulated protein 1 MIT PF04212.18 CAV17339.1 - 0.11 12.6 4.2 19 5.4 0.1 4.2 4 0 0 4 4 4 0 MIT (microtubule interacting and transport) domain TPR_6 PF13174.6 CAV17339.1 - 0.87 10.4 15.3 3.1 8.6 0.1 4.5 5 0 0 5 5 5 0 Tetratricopeptide repeat Adeno_E1A PF02703.14 CAV17339.1 - 2 7.9 5.1 1.2 8.7 0.2 2.0 1 1 1 2 2 2 0 Early E1A protein T2SSE PF00437.20 CAV17340.1 - 2.1e-76 256.6 1.8 3e-76 256.1 1.8 1.2 1 0 0 1 1 1 1 Type II/IV secretion system protein T2SSE_N PF05157.15 CAV17340.1 - 1.5e-24 86.4 5.9 1.8e-22 79.6 2.2 2.6 2 0 0 2 2 2 2 Type II secretion system (T2SS), protein E, N-terminal domain AAA_18 PF13238.6 CAV17340.1 - 0.00062 20.3 0.2 0.015 15.9 0.0 2.7 2 0 0 2 2 2 1 AAA domain AAA_11 PF13086.6 CAV17340.1 - 0.00085 19.2 0.0 0.0017 18.2 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 CAV17340.1 - 0.001 19.3 0.0 0.0031 17.8 0.0 1.9 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 CAV17340.1 - 0.0024 18.3 0.3 0.011 16.2 0.0 2.1 2 1 0 2 2 2 1 AAA ATPase domain AAA_29 PF13555.6 CAV17340.1 - 0.0056 16.4 0.0 0.014 15.1 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_23 PF13476.6 CAV17340.1 - 0.0093 16.5 0.1 0.026 15.0 0.0 1.7 2 0 0 2 2 2 1 AAA domain TrwB_AAD_bind PF10412.9 CAV17340.1 - 0.011 14.7 0.4 0.14 11.1 0.0 2.6 3 0 0 3 3 3 0 Type IV secretion-system coupling protein DNA-binding domain Rad17 PF03215.15 CAV17340.1 - 0.012 15.6 0.0 0.024 14.6 0.0 1.5 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_30 PF13604.6 CAV17340.1 - 0.016 14.9 0.0 0.046 13.4 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_19 PF13245.6 CAV17340.1 - 0.017 15.5 1.7 0.026 14.8 0.1 2.1 3 0 0 3 3 2 0 AAA domain NTPase_1 PF03266.15 CAV17340.1 - 0.021 14.8 0.5 0.21 11.5 0.3 2.3 1 1 1 2 2 2 0 NTPase FumaraseC_C PF10415.9 CAV17340.1 - 0.036 14.5 0.8 3.8 8.0 0.0 3.1 2 1 1 3 3 3 0 Fumarase C C-terminus Zeta_toxin PF06414.12 CAV17340.1 - 0.047 13.0 0.0 0.095 12.0 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin AAA_7 PF12775.7 CAV17340.1 - 0.068 12.7 0.1 0.18 11.3 0.0 1.7 2 0 0 2 2 2 0 P-loop containing dynein motor region SRP54 PF00448.22 CAV17340.1 - 0.072 12.7 0.0 0.13 11.9 0.0 1.4 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain ATPase_2 PF01637.18 CAV17340.1 - 0.078 12.9 0.0 0.18 11.7 0.0 1.6 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_14 PF13173.6 CAV17340.1 - 0.1 12.7 0.0 0.31 11.1 0.0 1.9 2 0 0 2 2 1 0 AAA domain SWM_repeat PF13753.6 CAV17340.1 - 0.14 12.3 0.3 0.41 10.8 0.0 1.9 2 0 0 2 2 1 0 Putative flagellar system-associated repeat T2SSF PF00482.23 CAV17341.1 - 2e-56 189.3 5.1 2.2e-28 98.7 0.1 2.3 2 0 0 2 2 2 2 Type II secretion system (T2SS), protein F DUF2207 PF09972.9 CAV17341.1 - 0.0012 17.7 0.4 0.0012 17.7 0.4 1.6 2 0 0 2 2 2 1 Predicted membrane protein (DUF2207) PetG PF02529.15 CAV17341.1 - 2.6 8.0 11.2 0.27 11.1 3.4 2.5 2 0 0 2 2 2 0 Cytochrome B6-F complex subunit 5 Wzz PF02706.15 CAV17342.1 - 0.024 14.9 0.2 0.032 14.5 0.2 1.2 1 0 0 1 1 1 0 Chain length determinant protein N_methyl PF07963.12 CAV17343.1 - 3.8e-08 32.6 2.2 5.6e-08 32.0 2.2 1.3 1 0 0 1 1 1 1 Prokaryotic N-terminal methylation motif DUF1455 PF07306.11 CAV17343.1 - 0.038 14.0 0.0 0.071 13.1 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1455) Flp1_like PF16982.5 CAV17343.1 - 0.19 11.2 2.4 0.3 10.5 2.4 1.3 1 0 0 1 1 1 0 Putative Flagellin, Flp1-like, domain N_methyl PF07963.12 CAV17344.1 - 3.3e-10 39.1 3.1 6.7e-10 38.1 3.1 1.6 1 0 0 1 1 1 1 Prokaryotic N-terminal methylation motif N_methyl PF07963.12 CAV17345.1 - 2e-07 30.2 1.5 2e-07 30.2 1.5 2.0 3 0 0 3 3 3 1 Prokaryotic N-terminal methylation motif PseudoU_synth_1 PF01416.20 CAV17345.1 - 0.0091 16.4 0.0 0.017 15.6 0.0 1.4 1 0 0 1 1 1 1 tRNA pseudouridine synthase DOT1 PF08123.13 CAV17345.1 - 0.029 13.9 0.3 0.044 13.3 0.3 1.2 1 0 0 1 1 1 0 Histone methylation protein DOT1 N_methyl PF07963.12 CAV17346.1 - 2.2e-06 27.0 1.5 4e-06 26.2 1.5 1.5 1 0 0 1 1 1 1 Prokaryotic N-terminal methylation motif 7TM_GPCR_Sri PF10327.9 CAV17346.1 - 0.15 11.2 1.1 1.2 8.3 0.4 1.9 2 0 0 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Sri N_methyl PF07963.12 CAV17347.1 - 2.4e-07 30.0 3.2 4.2e-07 29.2 3.2 1.4 1 0 0 1 1 1 1 Prokaryotic N-terminal methylation motif MreB_Mbl PF06723.13 CAV17350.1 - 1.2e-148 494.2 3.9 1.5e-148 493.9 3.9 1.0 1 0 0 1 1 1 1 MreB/Mbl protein HSP70 PF00012.20 CAV17350.1 - 3.1e-14 52.1 0.0 4.6e-14 51.5 0.0 1.5 1 0 0 1 1 1 1 Hsp70 protein Actin PF00022.19 CAV17350.1 - 2.3e-12 46.2 0.0 5.7e-08 31.8 0.0 2.1 1 1 0 2 2 2 2 Actin FtsA PF14450.6 CAV17350.1 - 8.4e-11 42.2 0.6 2.5e-10 40.7 0.1 2.0 2 1 0 2 2 2 1 Cell division protein FtsA PilM_2 PF11104.8 CAV17350.1 - 2.8e-08 33.2 0.0 0.001 18.2 0.0 2.3 2 0 0 2 2 2 2 Type IV pilus assembly protein PilM; Ppx-GppA PF02541.16 CAV17350.1 - 0.00071 19.1 0.1 0.0013 18.2 0.1 1.5 1 0 0 1 1 1 1 Ppx/GppA phosphatase family EutA PF06277.11 CAV17350.1 - 0.0019 17.1 0.1 0.0032 16.4 0.1 1.4 1 0 0 1 1 1 1 Ethanolamine utilisation protein EutA DDR PF08841.10 CAV17350.1 - 0.0021 17.1 0.7 0.021 13.8 0.2 2.1 2 0 0 2 2 2 1 Diol dehydratase reactivase ATPase-like domain MreC PF04085.14 CAV17351.1 - 5.1e-39 133.6 0.8 1e-38 132.6 0.4 1.6 1 1 1 2 2 2 1 rod shape-determining protein MreC MreD PF04093.12 CAV17352.1 - 3.4e-37 128.0 23.6 4.1e-37 127.7 23.6 1.0 1 0 0 1 1 1 1 rod shape-determining protein MreD Maf PF02545.14 CAV17353.1 - 4.2e-58 195.9 0.1 5.3e-58 195.5 0.1 1.1 1 0 0 1 1 1 1 Maf-like protein P34-Arc PF04045.14 CAV17353.1 - 0.0038 17.0 0.3 0.0052 16.5 0.3 1.1 1 0 0 1 1 1 1 Arp2/3 complex, 34 kD subunit p34-Arc Tugs PF17840.1 CAV17353.1 - 0.04 14.1 0.3 0.33 11.2 0.1 2.2 2 0 0 2 2 2 0 Tethering Ubl4a to BAGS domain RNase_E_G PF10150.9 CAV17354.1 - 1.5e-101 339.4 1.7 1.6e-101 339.3 0.6 1.6 2 0 0 2 2 2 1 Ribonuclease E/G family S1 PF00575.23 CAV17354.1 - 7.2e-06 26.3 0.2 1.7e-05 25.1 0.2 1.5 1 0 0 1 1 1 1 S1 RNA binding domain HARE-HTH PF05066.13 CAV17354.1 - 0.052 13.9 0.0 0.25 11.8 0.0 2.2 2 0 0 2 2 2 0 HB1, ASXL, restriction endonuclease HTH domain DUF3971 PF13116.6 CAV17355.1 - 3.7e-91 305.7 0.1 1.7e-90 303.5 0.0 2.3 2 0 0 2 2 2 1 Protein of unknown function AsmA_2 PF13502.6 CAV17355.1 - 6.1e-61 205.9 6.1 7.5e-60 202.3 2.2 3.6 3 0 0 3 3 3 2 AsmA-like C-terminal region CN_hydrolase PF00795.22 CAV17356.1 - 1.9e-46 158.6 0.0 2e-46 158.4 0.0 1.0 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase MPLKIP PF15502.6 CAV17356.1 - 0.19 11.9 0.0 0.36 11.1 0.0 1.4 1 0 0 1 1 1 0 M-phase-specific PLK1-interacting protein PmbA_TldD PF01523.16 CAV17357.1 - 2.8e-65 220.9 0.4 3.8e-65 220.5 0.4 1.2 1 0 0 1 1 1 1 Putative modulator of DNA gyrase PhoH PF02562.16 CAV17358.1 - 1.3e-54 184.8 0.0 2.2e-54 184.0 0.0 1.4 1 0 0 1 1 1 1 PhoH-like protein PIN_4 PF13638.6 CAV17358.1 - 1e-35 122.9 0.1 1.8e-35 122.1 0.1 1.5 1 0 0 1 1 1 1 PIN domain AAA_30 PF13604.6 CAV17358.1 - 1.2e-06 28.4 0.0 2.8e-06 27.2 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 CAV17358.1 - 0.00023 21.4 0.2 0.0012 19.1 0.0 2.2 2 0 0 2 2 2 1 AAA domain NB-ARC PF00931.22 CAV17358.1 - 0.0011 18.3 0.0 0.0022 17.2 0.0 1.5 1 0 0 1 1 1 1 NB-ARC domain Zot PF05707.12 CAV17358.1 - 0.0013 18.4 0.0 1.6 8.3 0.0 2.6 2 0 0 2 2 2 2 Zonular occludens toxin (Zot) DEAD PF00270.29 CAV17358.1 - 0.0014 18.4 0.6 0.072 12.8 0.0 2.8 3 0 0 3 3 3 1 DEAD/DEAH box helicase AAA_19 PF13245.6 CAV17358.1 - 0.0023 18.3 0.3 0.013 15.8 0.2 2.2 2 1 0 2 2 2 1 AAA domain DUF2075 PF09848.9 CAV17358.1 - 0.0027 17.0 0.0 0.0056 16.0 0.0 1.5 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) AAA_16 PF13191.6 CAV17358.1 - 0.0031 17.9 0.1 0.016 15.6 0.0 2.2 2 1 0 2 2 2 1 AAA ATPase domain PIN_9 PF18477.1 CAV17358.1 - 0.0038 17.5 0.1 0.14 12.5 0.0 2.7 2 0 0 2 2 2 1 PIN like domain AAA_14 PF13173.6 CAV17358.1 - 0.0099 15.9 0.2 9.5 6.3 0.0 3.2 3 0 0 3 3 3 0 AAA domain ResIII PF04851.15 CAV17358.1 - 0.012 15.6 0.2 0.076 13.0 0.0 2.4 3 1 0 3 3 3 0 Type III restriction enzyme, res subunit AAA_25 PF13481.6 CAV17358.1 - 0.015 14.9 0.0 0.041 13.4 0.0 1.7 1 0 0 1 1 1 0 AAA domain DnaB_C PF03796.15 CAV17358.1 - 0.025 13.9 0.4 1.2 8.4 0.0 2.7 3 0 0 3 3 3 0 DnaB-like helicase C terminal domain T2SSE PF00437.20 CAV17358.1 - 0.048 12.7 0.0 0.089 11.8 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein NACHT PF05729.12 CAV17358.1 - 0.048 13.6 0.0 0.11 12.4 0.0 1.6 1 0 0 1 1 1 0 NACHT domain Terminase_6 PF03237.15 CAV17358.1 - 0.074 12.7 0.0 0.16 11.6 0.0 1.6 1 0 0 1 1 1 0 Terminase-like family Helicase_RecD PF05127.14 CAV17358.1 - 0.095 12.5 0.1 0.24 11.2 0.1 1.7 1 1 0 1 1 1 0 Helicase AAA PF00004.29 CAV17358.1 - 0.37 11.2 1.7 0.66 10.4 0.2 2.4 3 1 0 3 3 1 0 ATPase family associated with various cellular activities (AAA) RapA_C PF12137.8 CAV17359.1 - 7.1e-145 482.6 0.0 1.2e-144 481.8 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase recycling family C-terminal Tudor_RapA PF18337.1 CAV17359.1 - 5.1e-26 90.6 0.1 1.5e-25 89.1 0.1 1.9 1 0 0 1 1 1 1 RapA N-terminal Tudor like domain Tudor_1_RapA PF18339.1 CAV17359.1 - 3.8e-24 84.4 0.4 8.9e-24 83.2 0.1 1.9 2 0 0 2 2 2 1 RapA N-terminal Tudor like domain 1 SNF2_N PF00176.23 CAV17359.1 - 6.4e-16 58.0 0.0 1.1e-15 57.2 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 CAV17359.1 - 8.3e-16 58.3 0.0 2e-15 57.1 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 CAV17359.1 - 2.6e-12 47.1 0.0 3.4e-11 43.4 0.0 2.4 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DEAD PF00270.29 CAV17359.1 - 6.4e-06 26.1 0.0 4.8e-05 23.2 0.0 2.5 3 0 0 3 3 3 1 DEAD/DEAH box helicase ARGLU PF15346.6 CAV17359.1 - 0.0085 16.0 0.9 0.0085 16.0 0.9 2.0 2 0 0 2 2 2 1 Arginine and glutamate-rich 1 Helicase_RecD PF05127.14 CAV17359.1 - 0.031 14.1 0.0 0.14 12.0 0.0 2.2 2 0 0 2 2 2 0 Helicase AAA_34 PF13872.6 CAV17359.1 - 0.065 12.1 0.0 0.2 10.5 0.0 1.7 1 1 0 1 1 1 0 P-loop containing NTP hydrolase pore-1 IstB_IS21 PF01695.17 CAV17359.1 - 0.12 12.1 0.0 3 7.6 0.0 2.5 2 0 0 2 2 2 0 IstB-like ATP binding protein PseudoU_synth_2 PF00849.22 CAV17360.1 - 4.9e-26 91.7 0.0 6.1e-26 91.4 0.0 1.1 1 0 0 1 1 1 1 RNA pseudouridylate synthase 2-Hacid_dh_C PF02826.19 CAV17361.1 - 2.1e-54 183.6 0.0 3.9e-54 182.7 0.0 1.4 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 CAV17361.1 - 9e-22 77.2 0.0 1e-21 77.0 0.0 1.1 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain AlaDh_PNT_C PF01262.21 CAV17361.1 - 0.0034 16.7 1.5 5.6 6.2 0.0 3.3 2 1 1 3 3 3 2 Alanine dehydrogenase/PNT, C-terminal domain IlvN PF07991.12 CAV17361.1 - 0.015 14.8 0.1 0.039 13.5 0.0 1.7 2 0 0 2 2 2 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain NAD_binding_2 PF03446.15 CAV17361.1 - 0.073 13.2 1.0 0.2 11.8 0.2 2.0 2 1 0 2 2 2 0 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_10 PF13460.6 CAV17361.1 - 0.075 12.9 0.2 0.23 11.4 0.0 1.8 2 1 0 2 2 2 0 NAD(P)H-binding XdhC_C PF13478.6 CAV17361.1 - 0.12 12.8 0.0 0.38 11.3 0.0 1.8 2 0 0 2 2 2 0 XdhC Rossmann domain Usp PF00582.26 CAV17362.1 - 7.1e-32 110.8 0.3 8.1e-32 110.7 0.3 1.0 1 0 0 1 1 1 1 Universal stress protein family FadR_C PF07840.12 CAV17362.1 - 0.13 12.1 0.0 0.16 11.9 0.0 1.2 1 0 0 1 1 1 0 FadR C-terminal domain DctM PF06808.12 CAV17363.1 - 3.4e-78 263.3 57.2 4.5e-76 256.3 57.2 2.3 1 1 0 1 1 1 1 Tripartite ATP-independent periplasmic transporter, DctM component DUF3394 PF11874.8 CAV17363.1 - 3.9e-70 235.2 0.2 1.1e-69 233.8 0.2 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF3394) NMT1_3 PF16868.5 CAV17364.1 - 3.6e-94 315.4 0.5 4.2e-94 315.2 0.5 1.0 1 0 0 1 1 1 1 NMT1-like family NMT1 PF09084.11 CAV17364.1 - 6.2e-08 32.8 0.0 1.1e-07 32.0 0.0 1.5 1 1 0 1 1 1 1 NMT1/THI5 like Arg_repressor PF01316.21 CAV17366.1 - 1.9e-23 82.0 0.1 3.8e-23 81.0 0.0 1.5 2 0 0 2 2 2 1 Arginine repressor, DNA binding domain Arg_repressor_C PF02863.18 CAV17366.1 - 2.8e-21 75.1 0.1 4.4e-21 74.5 0.1 1.3 1 0 0 1 1 1 1 Arginine repressor, C-terminal domain Longin_2 PF18639.1 CAV17366.1 - 0.065 13.1 0.0 0.087 12.7 0.0 1.1 1 0 0 1 1 1 0 Yeast longin domain Swi6_N PF18530.1 CAV17366.1 - 0.092 12.9 0.0 0.14 12.3 0.0 1.2 1 0 0 1 1 1 0 Swi6 N-terminal domain Ldh_1_C PF02866.18 CAV17367.1 - 3.4e-49 167.0 0.0 4.8e-49 166.5 0.0 1.2 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Ldh_1_N PF00056.23 CAV17367.1 - 4.3e-47 159.7 0.2 6.1e-47 159.3 0.2 1.2 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain Semialdhyde_dh PF01118.24 CAV17367.1 - 0.13 12.7 2.8 0.2 12.1 0.3 2.4 2 1 0 2 2 2 0 Semialdehyde dehydrogenase, NAD binding domain HTH_37 PF13744.6 CAV17367.1 - 0.16 11.9 0.0 0.8 9.7 0.0 2.1 2 0 0 2 2 2 0 Helix-turn-helix domain DUF956 PF06115.11 CAV17368.1 - 0.013 15.2 0.0 0.013 15.2 0.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF956) SspH PF08141.12 CAV17368.1 - 0.12 12.6 0.0 0.15 12.2 0.0 1.2 1 0 0 1 1 1 0 Small acid-soluble spore protein H family polyprenyl_synt PF00348.17 CAV17369.1 - 4.4e-74 248.8 0.1 5.7e-74 248.4 0.1 1.1 1 0 0 1 1 1 1 Polyprenyl synthetase DUF1216 PF06746.11 CAV17369.1 - 0.028 14.4 2.1 0.041 13.9 0.0 2.3 3 0 0 3 3 3 0 Protein of unknown function (DUF1216) Ribosomal_L21p PF00829.21 CAV17370.1 - 1.5e-39 134.4 1.7 1.6e-39 134.2 1.7 1.0 1 0 0 1 1 1 1 Ribosomal prokaryotic L21 protein ATP-synt_ab_N PF02874.23 CAV17370.1 - 0.084 13.4 1.4 0.16 12.5 1.2 1.5 1 1 0 1 1 1 0 ATP synthase alpha/beta family, beta-barrel domain Ribosomal_L27 PF01016.19 CAV17371.1 - 4.7e-39 132.3 3.7 5.1e-39 132.1 3.7 1.0 1 0 0 1 1 1 1 Ribosomal L27 protein NMT1 PF09084.11 CAV17371.1 - 0.03 14.3 0.0 0.03 14.2 0.0 1.0 1 0 0 1 1 1 0 NMT1/THI5 like GTP1_OBG PF01018.22 CAV17372.1 - 1.1e-54 184.3 7.9 1.4e-54 183.9 7.9 1.2 1 0 0 1 1 1 1 GTP1/OBG MMR_HSR1 PF01926.23 CAV17372.1 - 1.7e-22 79.7 0.0 2.7e-22 79.0 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 CAV17372.1 - 1.2e-06 28.1 0.0 5.3e-06 26.0 0.0 2.0 1 1 0 1 1 1 1 Ferrous iron transport protein B MeaB PF03308.16 CAV17372.1 - 0.026 13.5 0.1 3.7 6.4 0.0 2.3 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB RsgA_GTPase PF03193.16 CAV17372.1 - 0.029 14.3 0.1 0.14 12.1 0.0 2.0 2 0 0 2 2 2 0 RsgA GTPase Gtr1_RagA PF04670.12 CAV17372.1 - 0.12 11.7 0.0 0.17 11.2 0.0 1.2 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region ThrE_2 PF12821.7 CAV17375.1 - 1.7e-36 125.2 12.0 2e-36 125.0 12.0 1.1 1 0 0 1 1 1 1 Threonine/Serine exporter, ThrE ThrE PF06738.12 CAV17375.1 - 1.5e-05 24.5 13.7 2.7e-05 23.6 13.7 1.4 1 1 0 1 1 1 1 Putative threonine/serine exporter Phage_holin_3_1 PF05106.12 CAV17375.1 - 0.0086 16.5 0.9 0.022 15.2 0.2 2.0 2 0 0 2 2 2 1 Phage holin family (Lysis protein S) DHFR_1 PF00186.19 CAV17376.1 - 6.9e-59 198.1 0.0 7.9e-59 198.0 0.0 1.0 1 0 0 1 1 1 1 Dihydrofolate reductase Metallophos PF00149.28 CAV17377.1 - 9.4e-14 52.4 0.1 4.6e-13 50.1 0.0 1.9 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 CAV17377.1 - 0.00038 20.7 0.0 0.00056 20.1 0.0 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain FBPase_2 PF06874.11 CAV17377.1 - 0.25 9.6 0.0 0.54 8.5 0.0 1.5 2 0 0 2 2 2 0 Firmicute fructose-1,6-bisphosphatase DUF525 PF04379.14 CAV17378.1 - 1.8e-33 114.6 0.2 2.2e-33 114.3 0.2 1.1 1 0 0 1 1 1 1 ApaG domain DUF4354 PF14263.6 CAV17378.1 - 0.0035 17.1 0.0 0.0048 16.7 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4354) RrnaAD PF00398.20 CAV17379.1 - 2.1e-80 269.6 0.0 2.3e-80 269.5 0.0 1.0 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase NodS PF05401.11 CAV17379.1 - 0.033 13.8 0.0 0.36 10.4 0.0 2.0 2 0 0 2 2 2 0 Nodulation protein S (NodS) DUF5395 PF17373.2 CAV17379.1 - 0.053 14.2 0.1 0.14 12.9 0.1 1.7 1 0 0 1 1 1 0 Family of unknown function (DUF5395) PdxA PF04166.12 CAV17380.1 - 1e-105 353.2 0.1 1.2e-105 352.9 0.1 1.0 1 0 0 1 1 1 1 Pyridoxal phosphate biosynthetic protein PdxA Rotamase_3 PF13616.6 CAV17381.1 - 3.3e-47 159.8 0.0 1.1e-22 80.7 0.0 2.5 2 0 0 2 2 2 2 PPIC-type PPIASE domain Rotamase PF00639.21 CAV17381.1 - 2.1e-44 150.4 0.2 1.9e-21 76.8 0.0 2.9 3 0 0 3 3 3 2 PPIC-type PPIASE domain SurA_N PF09312.11 CAV17381.1 - 9.9e-43 145.0 7.2 2.1e-42 143.9 7.2 1.6 1 0 0 1 1 1 1 SurA N-terminal domain Rotamase_2 PF13145.6 CAV17381.1 - 1.2e-13 51.9 1.5 3.9e-05 24.5 0.0 3.7 2 2 2 4 4 4 2 PPIC-type PPIASE domain SurA_N_3 PF13624.6 CAV17381.1 - 1.4e-11 44.5 2.6 1.4e-11 44.5 2.6 1.9 2 0 0 2 2 2 1 SurA N-terminal domain SurA_N_2 PF13623.6 CAV17381.1 - 2.8e-06 27.3 2.4 2.8e-06 27.3 2.4 2.4 1 1 1 2 2 2 1 SurA N-terminal domain EF-hand_14 PF17959.1 CAV17381.1 - 0.04 14.3 0.1 0.097 13.0 0.1 1.7 1 0 0 1 1 1 0 EF-hand domain Acetyltransf_11 PF13720.6 CAV17381.1 - 0.13 12.8 0.3 4.8 7.7 0.0 2.9 2 1 1 3 3 3 0 Udp N-acetylglucosamine O-acyltransferase; Domain 2 DivIC PF04977.15 CAV17381.1 - 1.9 8.3 6.1 0.39 10.5 0.2 2.8 2 1 0 3 3 3 0 Septum formation initiator LptD PF04453.14 CAV17382.1 - 8.1e-111 371.0 18.3 8.1e-111 371.0 18.3 2.1 1 1 1 2 2 2 2 LPS transport system D OstA PF03968.14 CAV17382.1 - 5e-18 65.3 1.2 1.1e-17 64.3 1.2 1.6 1 0 0 1 1 1 1 OstA-like protein LptC PF06835.13 CAV17382.1 - 0.0069 16.0 0.9 1.3 8.6 1.0 2.4 2 0 0 2 2 2 2 Lipopolysaccharide-assembly, LptC-related OstA_2 PF13100.6 CAV17382.1 - 0.0087 15.7 0.8 0.021 14.4 0.1 2.0 2 0 0 2 2 2 1 OstA-like protein P2_N PF18628.1 CAV17382.1 - 0.012 15.4 0.1 1.2 8.9 0.0 2.7 3 0 0 3 3 3 0 Viral coat protein P2 N-terminal domain TerB PF05099.13 CAV17383.1 - 3.5e-18 65.9 0.2 6.5e-18 65.1 0.2 1.4 1 0 0 1 1 1 1 Tellurite resistance protein TerB DnaJ PF00226.31 CAV17383.1 - 1.4e-13 50.8 0.3 2.8e-13 49.8 0.3 1.5 1 0 0 1 1 1 1 DnaJ domain DUF533 PF04391.12 CAV17383.1 - 0.00035 20.2 0.1 0.47 10.0 0.0 2.4 2 0 0 2 2 2 2 Protein of unknown function (DUF533) Acetyltransf_11 PF13720.6 CAV17383.1 - 0.0022 18.4 0.8 2.8 8.4 0.0 3.8 2 2 1 3 3 3 1 Udp N-acetylglucosamine O-acyltransferase; Domain 2 DUF456 PF04306.13 CAV17383.1 - 0.026 14.8 1.2 0.043 14.1 1.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF456) RPT PF13446.6 CAV17383.1 - 0.046 13.7 0.0 0.11 12.5 0.0 1.6 1 0 0 1 1 1 0 A repeated domain in UCH-protein UBA_2 PF08587.11 CAV17383.1 - 0.068 13.3 0.9 2.4 8.4 0.1 3.1 2 1 0 2 2 2 0 Ubiquitin associated domain (UBA) DUF924 PF06041.11 CAV17384.1 - 7.7e-62 208.6 0.1 8.7e-62 208.5 0.1 1.0 1 0 0 1 1 1 1 Bacterial protein of unknown function (DUF924) DUF547 PF04784.14 CAV17385.1 - 1.1e-22 80.3 0.0 2e-22 79.5 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function, DUF547 Aconitase_C PF00694.19 CAV17386.1 - 4.6e-40 137.0 0.0 6.8e-40 136.4 0.0 1.2 1 0 0 1 1 1 1 Aconitase C-terminal domain DUF2459 PF09601.10 CAV17386.1 - 0.025 14.4 0.0 2.6 7.8 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2459) Aconitase PF00330.20 CAV17387.1 - 1.7e-159 531.7 4.2 2e-159 531.5 4.2 1.0 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) Iso_dh PF00180.20 CAV17388.1 - 1.6e-136 455.0 0.0 1.8e-136 454.9 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase HMGL-like PF00682.19 CAV17389.1 - 2e-102 342.3 4.5 2.7e-102 341.8 4.5 1.2 1 0 0 1 1 1 1 HMGL-like LeuA_dimer PF08502.10 CAV17389.1 - 1.5e-31 109.0 0.5 6.1e-31 107.1 0.0 2.2 2 1 0 2 2 2 1 LeuA allosteric (dimerisation) domain NAD_binding_10 PF13460.6 CAV17389.1 - 0.17 11.7 2.0 0.42 10.5 1.7 1.7 1 1 1 2 2 2 0 NAD(P)H-binding TetR_N PF00440.23 CAV17390.1 - 1.3e-12 47.3 0.1 2.2e-12 46.6 0.1 1.4 1 0 0 1 1 1 1 Bacterial regulatory proteins, tetR family TetR_C_32 PF09209.11 CAV17390.1 - 0.016 15.2 0.5 3.6 7.6 0.0 2.3 1 1 1 2 2 2 0 Tetracyclin repressor-like, C-terminal domain MerR PF00376.23 CAV17390.1 - 0.13 12.0 0.1 0.29 11.0 0.1 1.5 1 0 0 1 1 1 0 MerR family regulatory protein DsrC PF04358.13 CAV17390.1 - 0.16 12.5 0.1 0.35 11.4 0.1 1.6 1 0 0 1 1 1 0 DsrC like protein HlyD_3 PF13437.6 CAV17391.1 - 1.3e-09 38.7 1.1 0.044 14.5 0.0 3.9 3 0 0 3 3 3 3 HlyD family secretion protein Biotin_lipoyl_2 PF13533.6 CAV17391.1 - 0.0041 16.9 4.3 0.48 10.3 0.1 3.4 3 0 0 3 3 3 2 Biotin-lipoyl like ACR_tran PF00873.19 CAV17392.1 - 2.5e-154 515.4 4.8 2.9e-154 515.2 4.8 1.0 1 0 0 1 1 1 1 AcrB/AcrD/AcrF family MMPL PF03176.15 CAV17392.1 - 1.5e-06 27.4 19.4 2.2e-06 26.8 4.9 2.4 2 0 0 2 2 2 2 MMPL family SecD_SecF PF02355.16 CAV17392.1 - 1.7e-06 27.6 23.1 0.00026 20.4 5.8 2.8 3 0 0 3 3 3 2 Protein export membrane protein PAP2 PF01569.21 CAV17393.1 - 6.1e-18 64.9 9.5 8.3e-18 64.5 9.3 1.4 1 1 0 1 1 1 1 PAP2 superfamily PAP2_3 PF14378.6 CAV17393.1 - 2.1e-07 30.9 11.4 2e-06 27.6 11.4 2.0 1 1 0 1 1 1 1 PAP2 superfamily PAP2_C PF14360.6 CAV17393.1 - 0.22 12.1 6.6 0.14 12.7 2.7 2.2 2 1 1 3 3 3 0 PAP2 superfamily C-terminal DUF962 PF06127.11 CAV17393.1 - 0.26 11.4 0.1 0.26 11.4 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF962) Glyco_trans_1_3 PF13528.6 CAV17394.1 - 9e-40 136.9 0.0 1.3e-39 136.4 0.0 1.1 1 0 0 1 1 1 1 Glycosyl transferase family 1 Glyco_trans_4_4 PF13579.6 CAV17394.1 - 0.0066 16.9 0.0 0.015 15.8 0.0 1.6 1 0 0 1 1 1 1 Glycosyl transferase 4-like domain LysR_substrate PF03466.20 CAV17395.1 - 6.7e-20 71.3 0.0 1e-19 70.8 0.0 1.2 1 0 0 1 1 1 1 LysR substrate binding domain HTH_1 PF00126.27 CAV17395.1 - 6.4e-19 67.7 0.1 1.4e-18 66.6 0.1 1.6 1 0 0 1 1 1 1 Bacterial regulatory helix-turn-helix protein, lysR family AMP-binding PF00501.28 CAV17396.1 - 4.6e-97 325.3 0.0 5.7e-97 325.0 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme TPP_enzyme_N PF02776.18 CAV17397.1 - 4.8e-58 195.6 0.0 3.2e-56 189.6 0.0 2.2 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_C PF02775.21 CAV17397.1 - 6.1e-52 175.5 0.2 6.2e-50 169.0 0.0 3.2 3 1 0 3 3 3 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain TPP_enzyme_M PF00205.22 CAV17397.1 - 6.3e-49 165.2 0.0 2.7e-48 163.2 0.0 2.0 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, central domain DAGK_cat PF00781.24 CAV17397.1 - 0.017 14.7 0.3 14 5.3 0.1 3.3 3 0 0 3 3 3 0 Diacylglycerol kinase catalytic domain ALS_ss_C PF10369.9 CAV17398.1 - 1.7e-25 89.0 0.9 1.7e-25 89.0 0.9 2.0 2 0 0 2 2 2 1 Small subunit of acetolactate synthase ACT_5 PF13710.6 CAV17398.1 - 4.1e-18 65.0 0.0 9.5e-18 63.8 0.0 1.6 1 0 0 1 1 1 1 ACT domain ACT PF01842.25 CAV17398.1 - 2.7e-15 55.8 0.0 6.9e-15 54.5 0.0 1.7 1 0 0 1 1 1 1 ACT domain ACT_4 PF13291.6 CAV17398.1 - 1.9e-07 31.6 0.2 1.7e-05 25.3 0.1 2.4 2 0 0 2 2 2 1 ACT domain OmdA PF13376.6 CAV17399.1 - 0.032 14.2 0.1 0.039 14.0 0.1 1.4 1 0 0 1 1 1 0 Bacteriocin-protection, YdeI or OmpD-Associated FCD PF07729.12 CAV17400.1 - 3.5e-17 63.0 0.4 4.6e-17 62.6 0.4 1.1 1 0 0 1 1 1 1 FCD domain GntR PF00392.21 CAV17400.1 - 5e-15 54.9 0.0 1e-14 53.9 0.0 1.6 1 0 0 1 1 1 1 Bacterial regulatory proteins, gntR family PK PF00224.21 CAV17401.1 - 6.8e-153 508.6 11.8 9.7e-153 508.1 11.8 1.1 1 0 0 1 1 1 1 Pyruvate kinase, barrel domain PK_C PF02887.16 CAV17401.1 - 1.7e-28 99.2 1.3 5.7e-28 97.5 1.3 1.9 1 0 0 1 1 1 1 Pyruvate kinase, alpha/beta domain HpcH_HpaI PF03328.14 CAV17401.1 - 3e-05 23.3 0.7 0.00012 21.3 0.6 2.0 1 1 1 2 2 2 1 HpcH/HpaI aldolase/citrate lyase family DUF2399 PF09664.10 CAV17401.1 - 0.093 12.7 0.0 0.31 11.0 0.0 1.9 1 0 0 1 1 1 0 Protein of unknown function C-terminus (DUF2399) DeoRC PF00455.22 CAV17402.1 - 2.5e-44 151.0 0.3 3.3e-44 150.6 0.3 1.2 1 0 0 1 1 1 1 DeoR C terminal sensor domain HTH_DeoR PF08220.12 CAV17402.1 - 7.4e-16 57.7 0.0 2.2e-15 56.1 0.0 1.9 2 0 0 2 2 2 1 DeoR-like helix-turn-helix domain HTH_11 PF08279.12 CAV17402.1 - 6.1e-07 29.3 0.5 1.4e-06 28.1 0.1 1.8 2 0 0 2 2 2 1 HTH domain GntR PF00392.21 CAV17402.1 - 0.00027 20.5 0.3 0.0036 16.9 0.1 2.6 2 0 0 2 2 2 1 Bacterial regulatory proteins, gntR family FeoC PF09012.10 CAV17402.1 - 0.001 19.1 0.0 0.0018 18.3 0.0 1.4 1 0 0 1 1 1 1 FeoC like transcriptional regulator Rrf2 PF02082.20 CAV17402.1 - 0.0081 16.5 0.0 0.02 15.2 0.0 1.7 1 0 0 1 1 1 1 Transcriptional regulator HTH_Mga PF08280.11 CAV17402.1 - 0.017 15.1 0.0 0.038 14.0 0.0 1.5 1 0 0 1 1 1 0 M protein trans-acting positive regulator (MGA) HTH domain Put_DNA-bind_N PF06971.13 CAV17402.1 - 0.027 14.5 0.0 0.068 13.2 0.0 1.7 1 0 0 1 1 1 0 Putative DNA-binding protein N-terminus DDRGK PF09756.9 CAV17402.1 - 0.062 12.9 0.1 0.1 12.2 0.1 1.3 1 0 0 1 1 1 0 DDRGK domain SIS PF01380.22 CAV17403.1 - 4.2e-60 201.3 1.0 7.3e-33 113.2 0.4 2.4 2 0 0 2 2 2 2 SIS domain GATase_6 PF13522.6 CAV17403.1 - 3.4e-22 79.1 0.2 7.5e-22 78.0 0.2 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_7 PF13537.6 CAV17403.1 - 7.9e-15 54.9 0.0 1.6e-14 53.9 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_4 PF13230.6 CAV17403.1 - 0.0043 16.0 0.1 0.015 14.2 0.1 1.8 2 0 0 2 2 2 1 Glutamine amidotransferases class-II Nif11 PF07862.11 CAV17403.1 - 0.014 15.6 0.0 0.28 11.5 0.0 2.7 2 0 0 2 2 2 0 Nif11 domain SIS_2 PF13580.6 CAV17403.1 - 0.047 13.7 0.0 0.17 11.9 0.0 2.1 1 0 0 1 1 1 0 SIS domain Cys_Met_Meta_PP PF01053.20 CAV17404.1 - 1.2e-140 468.4 0.0 1.4e-140 468.2 0.0 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_5 PF00266.19 CAV17404.1 - 2.6e-10 39.8 0.4 4.4e-10 39.1 0.4 1.3 1 0 0 1 1 1 1 Aminotransferase class-V Aminotran_1_2 PF00155.21 CAV17404.1 - 6.2e-10 38.8 0.0 9.8e-10 38.1 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class I and II DegT_DnrJ_EryC1 PF01041.17 CAV17404.1 - 6e-08 32.4 0.4 3.6e-07 29.8 0.2 1.9 2 0 0 2 2 2 1 DegT/DnrJ/EryC1/StrS aminotransferase family Beta_elim_lyase PF01212.21 CAV17404.1 - 1.6e-05 24.4 0.0 2.5e-05 23.7 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase GDC-P PF02347.16 CAV17404.1 - 0.0013 17.7 0.0 0.0019 17.1 0.0 1.2 1 0 0 1 1 1 1 Glycine cleavage system P-protein Met_gamma_lyase PF06838.11 CAV17404.1 - 0.019 13.5 0.0 0.038 12.5 0.0 1.5 1 0 0 1 1 1 0 Methionine gamma-lyase Sigma70_ner PF04546.13 CAV17405.1 - 2e-63 214.0 3.8 2e-63 214.0 3.8 3.0 4 0 0 4 4 4 1 Sigma-70, non-essential region Sigma70_r3 PF04539.16 CAV17405.1 - 1.4e-28 98.8 1.2 1.4e-28 98.8 1.2 3.0 3 0 0 3 3 3 1 Sigma-70 region 3 Sigma70_r1_1 PF03979.14 CAV17405.1 - 7.2e-28 96.5 4.8 7.2e-28 96.5 4.8 3.2 3 0 0 3 3 3 1 Sigma-70 factor, region 1.1 Sigma70_r2 PF04542.14 CAV17405.1 - 6.3e-22 77.1 0.3 1.8e-21 75.6 0.3 1.9 1 0 0 1 1 1 1 Sigma-70 region 2 Sigma70_r4 PF04545.16 CAV17405.1 - 1.8e-19 69.0 0.5 1.8e-19 69.0 0.5 3.5 3 0 0 3 3 3 1 Sigma-70, region 4 Sigma70_r1_2 PF00140.20 CAV17405.1 - 3.6e-13 49.3 4.0 2.2e-12 46.8 0.3 3.3 3 0 0 3 3 3 1 Sigma-70 factor, region 1.2 TMPIT PF07851.13 CAV17405.1 - 0.054 12.7 0.1 0.11 11.7 0.1 1.5 1 0 0 1 1 1 0 TMPIT-like protein Ribosomal_60s PF00428.19 CAV17405.1 - 0.091 13.4 8.9 0.37 11.4 2.5 3.0 2 0 0 2 2 2 0 60s Acidic ribosomal protein Toprim_N PF08275.11 CAV17406.1 - 2.2e-42 144.2 0.0 4e-42 143.3 0.0 1.5 1 0 0 1 1 1 1 DNA primase catalytic core, N-terminal domain zf-CHC2 PF01807.20 CAV17406.1 - 1.1e-41 140.6 0.1 2.6e-41 139.4 0.1 1.7 1 0 0 1 1 1 1 CHC2 zinc finger DnaG_DnaB_bind PF08278.11 CAV17406.1 - 1.6e-36 125.6 2.5 9.5e-36 123.1 1.1 2.3 2 0 0 2 2 2 1 DNA primase DnaG DnaB-binding Toprim_4 PF13662.6 CAV17406.1 - 1.1e-13 51.4 0.0 2.3e-13 50.4 0.0 1.6 1 0 0 1 1 1 1 Toprim domain Toprim_2 PF13155.6 CAV17406.1 - 1.6e-13 50.9 0.0 4.2e-13 49.5 0.0 1.8 1 0 0 1 1 1 1 Toprim-like DnaB_bind PF10410.9 CAV17406.1 - 8.8e-10 38.6 0.4 3.8e-09 36.6 0.0 2.3 3 0 0 3 3 3 1 DnaB-helicase binding domain of primase Toprim PF01751.22 CAV17406.1 - 3.4e-09 36.8 0.0 7.8e-09 35.7 0.0 1.6 1 0 0 1 1 1 1 Toprim domain Toprim_3 PF13362.6 CAV17406.1 - 8.4e-07 29.3 0.0 1.9e-06 28.1 0.0 1.6 2 0 0 2 2 2 1 Toprim domain Vps36-NZF-N PF16988.5 CAV17406.1 - 0.15 11.5 1.0 0.31 10.5 1.0 1.4 1 0 0 1 1 1 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain YqeY PF09424.10 CAV17407.1 - 7.8e-55 184.9 7.0 8.7e-55 184.7 7.0 1.0 1 0 0 1 1 1 1 Yqey-like protein Ribosomal_S21 PF01165.20 CAV17408.1 - 6e-23 80.3 6.4 6e-23 80.3 6.4 1.8 1 1 1 2 2 2 1 Ribosomal protein S21 Peptidase_M22 PF00814.25 CAV17409.1 - 1e-102 343.5 0.0 1.2e-102 343.3 0.0 1.0 1 0 0 1 1 1 1 Glycoprotease family Carbam_trans_N PF02543.15 CAV17409.1 - 9.6e-05 22.2 0.0 0.0014 18.4 0.0 2.0 2 0 0 2 2 2 1 Carbamoyltransferase N-terminus BcrAD_BadFG PF01869.20 CAV17409.1 - 0.0019 17.8 0.0 0.0037 16.8 0.0 1.4 1 1 0 1 1 1 1 BadF/BadG/BcrA/BcrD ATPase family NBD_C PF17042.5 CAV17409.1 - 0.028 14.9 0.1 0.11 13.1 0.1 1.9 3 0 0 3 3 3 0 Nucleotide-binding C-terminal domain TrwC PF08751.11 CAV17409.1 - 0.13 11.8 0.0 0.13 11.8 0.0 1.1 1 0 0 1 1 1 0 TrwC relaxase Abhydrolase_1 PF00561.20 CAV17410.1 - 1e-17 64.6 0.0 2.1e-13 50.5 0.0 2.1 1 1 1 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CAV17410.1 - 1.3e-15 58.6 0.0 8.3e-15 56.0 0.0 1.8 1 1 1 2 2 2 1 Alpha/beta hydrolase family Ndr PF03096.14 CAV17410.1 - 2.8e-09 36.1 0.0 3.7e-09 35.7 0.0 1.1 1 0 0 1 1 1 1 Ndr family Hydrolase_4 PF12146.8 CAV17410.1 - 2.2e-07 30.4 0.0 9.4e-07 28.3 0.0 2.0 1 1 1 2 2 2 1 Serine aminopeptidase, S33 Abhydrolase_4 PF08386.10 CAV17410.1 - 0.11 12.7 0.0 0.32 11.1 0.0 1.7 2 0 0 2 2 2 0 TAP-like protein G3P_acyltransf PF02660.15 CAV17411.1 - 1.3e-51 174.9 10.7 1.6e-51 174.6 10.7 1.0 1 0 0 1 1 1 1 Glycerol-3-phosphate acyltransferase DUF4233 PF14017.6 CAV17411.1 - 8.5 6.8 13.8 0.075 13.4 0.8 2.9 1 1 2 3 3 3 0 Protein of unknown function (DUF4233) FolB PF02152.18 CAV17412.1 - 9e-31 106.7 0.3 1e-30 106.6 0.3 1.0 1 0 0 1 1 1 1 Dihydroneopterin aldolase HPPK PF01288.20 CAV17413.1 - 1.5e-22 80.3 0.0 1.8e-22 79.9 0.0 1.1 1 0 0 1 1 1 1 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK) MIF4G_like PF09088.11 CAV17413.1 - 0.073 12.8 0.1 0.73 9.6 0.1 1.9 1 1 1 2 2 2 0 MIF4G like BacA PF02673.18 CAV17414.1 - 1.7e-83 280.3 16.9 1.9e-83 280.1 16.9 1.0 1 0 0 1 1 1 1 Bacitracin resistance protein BacA BTB PF00651.31 CAV17414.1 - 0.025 14.8 0.0 0.041 14.1 0.0 1.2 1 0 0 1 1 1 0 BTB/POZ domain PLDc_N PF13396.6 CAV17414.1 - 0.03 14.3 0.1 0.03 14.3 0.1 3.0 1 1 1 2 2 2 0 Phospholipase_D-nuclease N-terminal SPC12 PF06645.13 CAV17414.1 - 0.38 10.9 0.1 0.38 10.9 0.1 3.4 4 0 0 4 4 4 0 Microsomal signal peptidase 12 kDa subunit (SPC12) PolyA_pol PF01743.20 CAV17415.1 - 5.6e-18 65.6 0.1 3.5e-17 63.0 0.1 2.1 1 1 0 1 1 1 1 Poly A polymerase head domain PolyA_pol_RNAbd PF12627.7 CAV17415.1 - 2.5e-12 46.4 0.0 5e-12 45.4 0.0 1.6 1 0 0 1 1 1 1 Probable RNA and SrmB- binding site of polymerase A HD PF01966.22 CAV17415.1 - 1.3e-08 35.1 0.1 2.8e-08 34.0 0.0 1.7 2 0 0 2 2 2 1 HD domain AAA_22 PF13401.6 CAV17416.1 - 1.6e-24 86.7 0.9 7.7e-24 84.5 0.4 2.1 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 CAV17416.1 - 5.8e-08 33.3 1.9 2.3e-07 31.4 1.9 2.0 1 0 0 1 1 1 1 AAA ATPase domain AAA_30 PF13604.6 CAV17416.1 - 8.9e-08 32.1 0.2 1.7e-07 31.2 0.2 1.4 1 0 0 1 1 1 1 AAA domain PG_binding_1 PF01471.18 CAV17416.1 - 3.5e-06 27.1 0.0 9.7e-06 25.7 0.0 1.8 1 0 0 1 1 1 1 Putative peptidoglycan binding domain DUF2075 PF09848.9 CAV17416.1 - 5.2e-05 22.7 0.1 9.5e-05 21.8 0.1 1.3 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) TniB PF05621.11 CAV17416.1 - 5.5e-05 22.7 1.5 0.00016 21.2 1.5 1.7 1 1 0 1 1 1 1 Bacterial TniB protein AAA PF00004.29 CAV17416.1 - 0.0001 22.7 0.0 0.00018 22.0 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) TsaE PF02367.17 CAV17416.1 - 0.00033 20.6 0.0 0.00079 19.4 0.0 1.6 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_18 PF13238.6 CAV17416.1 - 0.00056 20.5 0.0 0.0017 18.9 0.0 1.8 2 0 0 2 2 1 1 AAA domain AAA_5 PF07728.14 CAV17416.1 - 0.0014 18.6 0.2 0.0041 17.1 0.1 1.8 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_19 PF13245.6 CAV17416.1 - 0.0017 18.7 2.2 0.011 16.1 2.2 2.2 1 1 0 1 1 1 1 AAA domain AAA_7 PF12775.7 CAV17416.1 - 0.0017 17.9 0.0 0.0031 17.1 0.0 1.3 1 0 0 1 1 1 1 P-loop containing dynein motor region Helicase_RecD PF05127.14 CAV17416.1 - 0.0028 17.5 0.0 0.0071 16.2 0.0 1.7 1 0 0 1 1 1 1 Helicase ResIII PF04851.15 CAV17416.1 - 0.012 15.7 0.2 0.071 13.1 0.2 2.1 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit RsgA_GTPase PF03193.16 CAV17416.1 - 0.012 15.5 1.5 0.047 13.6 0.1 2.2 2 0 0 2 2 2 0 RsgA GTPase Sigma54_activat PF00158.26 CAV17416.1 - 0.014 15.1 0.1 0.014 15.1 0.1 1.9 2 1 0 2 2 2 0 Sigma-54 interaction domain ABC_tran PF00005.27 CAV17416.1 - 0.025 15.1 0.1 0.051 14.1 0.1 1.6 1 0 0 1 1 1 0 ABC transporter TrwB_AAD_bind PF10412.9 CAV17416.1 - 0.037 12.9 0.1 0.037 12.9 0.1 1.5 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain PIF1 PF05970.14 CAV17416.1 - 0.064 12.4 0.0 0.12 11.6 0.0 1.4 1 0 0 1 1 1 0 PIF1-like helicase Mg_chelatase PF01078.21 CAV17416.1 - 0.07 12.5 0.5 1.9 7.8 0.1 2.2 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_11 PF13086.6 CAV17416.1 - 0.07 12.9 0.4 0.26 11.0 0.2 1.9 2 1 0 2 2 1 0 AAA domain NB-ARC PF00931.22 CAV17416.1 - 0.077 12.2 0.0 0.13 11.5 0.0 1.4 1 0 0 1 1 1 0 NB-ARC domain AAA_25 PF13481.6 CAV17416.1 - 0.09 12.3 0.0 0.27 10.8 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.6 CAV17416.1 - 0.12 12.1 0.0 0.24 11.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain cobW PF02492.19 CAV17416.1 - 0.14 11.7 0.0 0.28 10.8 0.0 1.4 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain NTPase_1 PF03266.15 CAV17416.1 - 0.15 12.0 1.6 0.25 11.2 0.1 2.1 3 0 0 3 3 2 0 NTPase AAA_29 PF13555.6 CAV17416.1 - 0.17 11.6 0.5 0.41 10.4 0.5 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain Sigma54_activ_2 PF14532.6 CAV17416.1 - 0.22 11.6 3.9 11 6.1 3.9 2.6 1 1 0 1 1 1 0 Sigma-54 interaction domain DEAD PF00270.29 CAV17416.1 - 0.46 10.2 2.0 2.5 7.8 2.0 2.0 1 1 0 1 1 1 0 DEAD/DEAH box helicase T2SSB PF16537.5 CAV17417.1 - 1.9e-23 81.8 0.0 3.7e-23 80.9 0.0 1.5 1 0 0 1 1 1 1 Type II secretion system protein B PilX_N PF14341.6 CAV17417.1 - 0.12 12.3 0.4 0.26 11.3 0.4 1.6 1 0 0 1 1 1 0 PilX N-terminal SH3_3 PF08239.11 CAV17418.1 - 8.3e-09 35.6 0.1 1.5e-08 34.8 0.1 1.4 1 0 0 1 1 1 1 Bacterial SH3 domain Atg14 PF10186.9 CAV17418.1 - 4.9e-05 22.6 0.7 5.7e-05 22.3 0.7 1.2 1 0 0 1 1 1 1 Vacuolar sorting 38 and autophagy-related subunit 14 CENP-F_leu_zip PF10473.9 CAV17418.1 - 0.00038 20.5 6.6 0.00049 20.1 6.6 1.1 1 0 0 1 1 1 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF1664 PF07889.12 CAV17418.1 - 0.00082 19.4 1.6 0.0012 18.9 1.6 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1664) TPR_MLP1_2 PF07926.12 CAV17418.1 - 0.0018 18.3 8.8 0.0026 17.8 8.8 1.2 1 0 0 1 1 1 1 TPR/MLP1/MLP2-like protein FlaC_arch PF05377.11 CAV17418.1 - 0.0023 18.3 3.2 0.2 12.1 0.8 2.3 2 0 0 2 2 2 1 Flagella accessory protein C (FlaC) Med9 PF07544.13 CAV17418.1 - 0.0044 17.1 5.2 0.013 15.6 5.2 1.8 1 1 0 1 1 1 1 RNA polymerase II transcription mediator complex subunit 9 FapA PF03961.13 CAV17418.1 - 0.0069 15.0 1.5 0.0081 14.8 1.5 1.1 1 0 0 1 1 1 1 Flagellar Assembly Protein A DUF4164 PF13747.6 CAV17418.1 - 0.0089 16.3 2.1 0.018 15.3 2.1 1.5 1 1 0 1 1 1 1 Domain of unknown function (DUF4164) UPF0242 PF06785.11 CAV17418.1 - 0.0094 16.1 4.1 0.012 15.7 4.1 1.2 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0242) N-terminus DUF4407 PF14362.6 CAV17418.1 - 0.011 15.1 1.6 0.023 14.1 1.3 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) SHE3 PF17078.5 CAV17418.1 - 0.019 14.7 5.0 0.03 14.1 5.0 1.3 1 0 0 1 1 1 0 SWI5-dependent HO expression protein 3 IFT57 PF10498.9 CAV17418.1 - 0.022 13.8 4.9 0.026 13.5 4.9 1.1 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 Phage_GP20 PF06810.11 CAV17418.1 - 0.023 14.5 3.5 0.038 13.8 3.5 1.4 1 0 0 1 1 1 0 Phage minor structural protein GP20 UPF0184 PF03670.13 CAV17418.1 - 0.024 15.0 2.8 0.042 14.2 2.8 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0184) MscS_porin PF12795.7 CAV17418.1 - 0.034 13.7 10.7 0.046 13.3 10.7 1.1 1 0 0 1 1 1 0 Mechanosensitive ion channel porin domain APG6_N PF17675.1 CAV17418.1 - 0.042 14.4 5.6 0.058 13.9 5.6 1.2 1 0 0 1 1 1 0 Apg6 coiled-coil region ABC_tran_CTD PF16326.5 CAV17418.1 - 0.092 13.0 6.8 0.27 11.5 2.6 2.3 1 1 1 2 2 2 0 ABC transporter C-terminal domain Ead_Ea22 PF13935.6 CAV17418.1 - 0.17 12.5 2.5 6.5 7.4 0.5 2.2 1 1 1 2 2 2 0 Ead/Ea22-like protein DUF1043 PF06295.12 CAV17418.1 - 0.2 11.7 5.9 0.4 10.7 5.9 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1043) Med21 PF11221.8 CAV17418.1 - 0.2 11.9 7.5 0.45 10.8 1.8 2.2 1 1 1 2 2 2 0 Subunit 21 of Mediator complex DUF4201 PF13870.6 CAV17418.1 - 0.21 11.3 6.6 0.22 11.3 3.1 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4201) Spc7 PF08317.11 CAV17418.1 - 0.22 10.3 8.2 0.3 9.9 8.2 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF3450 PF11932.8 CAV17418.1 - 0.24 10.7 5.5 0.41 9.9 5.5 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) TolA_bind_tri PF16331.5 CAV17418.1 - 0.27 11.3 6.4 0.98 9.5 5.3 2.1 1 1 1 2 2 2 0 TolA binding protein trimerisation FPP PF05911.11 CAV17418.1 - 0.28 9.3 9.0 0.98 7.5 8.8 1.6 1 1 0 1 1 1 0 Filament-like plant protein, long coiled-coil Jnk-SapK_ap_N PF09744.9 CAV17418.1 - 0.35 11.1 7.9 0.5 10.6 7.4 1.4 1 1 0 1 1 1 0 JNK_SAPK-associated protein-1 THOC7 PF05615.13 CAV17418.1 - 0.36 11.1 8.2 1.3 9.3 8.1 1.7 1 1 0 1 1 1 0 Tho complex subunit 7 Cortex-I_coil PF09304.10 CAV17418.1 - 0.39 10.9 7.2 0.63 10.3 7.2 1.3 1 0 0 1 1 1 0 Cortexillin I, coiled coil YabA PF06156.13 CAV17418.1 - 0.49 11.1 4.5 0.48 11.1 1.8 2.0 1 1 1 2 2 2 0 Initiation control protein YabA Prefoldin_2 PF01920.20 CAV17418.1 - 0.57 10.2 7.6 3.2 7.7 3.0 2.3 1 1 1 2 2 2 0 Prefoldin subunit Ribosomal_L29 PF00831.23 CAV17418.1 - 0.7 9.9 5.4 13 5.9 0.2 2.6 2 0 0 2 2 2 0 Ribosomal L29 protein PRKG1_interact PF15898.5 CAV17418.1 - 0.73 10.8 8.3 2.1 9.3 8.3 1.7 1 1 0 1 1 1 0 cGMP-dependent protein kinase interacting domain DUF3053 PF11254.8 CAV17418.1 - 0.94 9.0 7.2 4.1 6.9 0.4 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3053) CENP-H PF05837.12 CAV17418.1 - 2 8.9 9.6 1.7 9.1 3.7 2.1 1 1 1 2 2 2 0 Centromere protein H (CENP-H) Mto2_bdg PF12808.7 CAV17418.1 - 2.7 8.3 6.5 1.1 9.7 1.7 2.3 1 1 1 2 2 2 0 Micro-tubular organiser Mto1 C-term Mto2-binding region ADIP PF11559.8 CAV17418.1 - 2.8 8.0 11.1 6.7 6.8 10.9 1.7 1 1 0 1 1 1 0 Afadin- and alpha -actinin-Binding GrpE PF01025.19 CAV17418.1 - 4.4 6.9 7.4 15 5.2 7.4 1.8 1 1 0 1 1 1 0 GrpE bZIP_Maf PF03131.17 CAV17418.1 - 5.4 7.6 9.3 3.6 8.2 4.1 2.2 1 1 1 2 2 2 0 bZIP Maf transcription factor SlyX PF04102.12 CAV17418.1 - 5.8 7.6 7.2 11 6.7 3.3 2.2 1 1 1 2 2 2 0 SlyX Swi5 PF07061.11 CAV17418.1 - 7.6 6.7 7.0 22 5.2 2.2 2.4 1 1 1 2 2 2 0 Swi5 PHO4 PF01384.20 CAV17419.1 - 5.3e-113 377.5 39.3 6.6e-113 377.2 39.3 1.1 1 0 0 1 1 1 1 Phosphate transporter family PhoU_div PF01865.16 CAV17420.1 - 8.7e-65 218.0 0.7 9.7e-65 217.9 0.7 1.0 1 0 0 1 1 1 1 Protein of unknown function DUF47 HbrB PF08539.11 CAV17420.1 - 0.13 12.3 0.2 0.27 11.2 0.1 1.6 2 0 0 2 2 2 0 HbrB-like UVR PF02151.19 CAV17420.1 - 0.13 12.0 2.9 0.26 11.1 0.0 2.7 3 0 0 3 3 3 0 UvrB/uvrC motif YflT PF11181.8 CAV17420.1 - 0.15 12.5 0.4 0.39 11.3 0.4 1.6 1 0 0 1 1 1 0 Heat induced stress protein YflT CYTH PF01928.21 CAV17421.1 - 1.3e-34 119.7 0.1 8.1e-34 117.1 0.0 2.1 2 0 0 2 2 2 1 CYTH domain CHAD PF05235.14 CAV17421.1 - 1.4e-08 35.0 2.5 1.4e-08 35.0 2.5 1.5 2 0 0 2 2 2 1 CHAD domain BRX_N PF13713.6 CAV17421.1 - 0.088 12.6 0.3 0.16 11.7 0.3 1.4 1 0 0 1 1 1 0 Transcription factor BRX N-terminal domain Ion_trans PF00520.31 CAV17422.1 - 2.5e-16 59.6 6.9 4e-16 59.0 6.9 1.3 1 1 0 1 1 1 1 Ion transport protein Ion_trans_2 PF07885.16 CAV17422.1 - 5.3e-13 48.7 7.5 5.3e-13 48.7 7.5 2.6 3 1 1 4 4 4 1 Ion channel YfhO PF09586.10 CAV17422.1 - 4e-05 22.1 3.5 6.7e-05 21.3 0.1 1.9 1 1 1 2 2 2 1 Bacterial membrane protein YfhO EI24 PF07264.11 CAV17422.1 - 0.001 19.3 4.1 0.033 14.5 0.0 2.3 2 1 0 2 2 2 1 Etoposide-induced protein 2.4 (EI24) DUF4271 PF14093.6 CAV17422.1 - 0.021 14.8 7.7 1.3 8.8 2.6 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF4271) DUF2749 PF10907.8 CAV17422.1 - 0.069 13.3 0.3 2.6 8.3 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2749) p12I PF12233.8 CAV17422.1 - 0.12 12.9 5.3 0.072 13.6 2.3 2.1 2 0 0 2 2 2 0 Human adult T cell leukemia/lymphoma virus protein HemY_N PF07219.13 CAV17422.1 - 0.15 12.2 3.8 11 6.2 0.0 3.5 3 1 1 4 4 4 0 HemY protein N-terminus Sigma_reg_N PF13800.6 CAV17422.1 - 1.1 9.6 0.0 1.1 9.6 0.0 3.4 4 1 1 5 5 5 0 Sigma factor regulator N-terminal 7TM-7TMR_HD PF07698.11 CAV17422.1 - 1.5 8.5 13.0 0.3 10.8 4.2 2.5 2 1 0 2 2 2 0 7TM receptor with intracellular HD hydrolase OST3_OST6 PF04756.13 CAV17422.1 - 2.7 7.3 8.5 0.84 8.9 0.9 2.5 1 1 1 2 2 2 0 OST3 / OST6 family, transporter family MCPsignal PF00015.21 CAV17423.1 - 1.1e-42 145.8 24.2 1.1e-42 145.8 24.2 2.6 1 1 1 2 2 2 1 Methyl-accepting chemotaxis protein (MCP) signalling domain HAMP PF00672.25 CAV17423.1 - 0.0011 19.3 0.8 0.065 13.6 0.0 3.4 3 0 0 3 3 3 1 HAMP domain BLOC1_2 PF10046.9 CAV17423.1 - 0.0012 19.1 19.3 0.3 11.4 1.9 4.5 3 2 1 4 4 4 3 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF4763 PF15960.5 CAV17423.1 - 0.099 11.9 1.7 1.5 8.1 0.0 2.7 2 1 1 3 3 3 0 Domain of unknown function (DUF4763) Laminin_II PF06009.12 CAV17423.1 - 0.12 12.4 22.9 0.56 10.2 4.4 3.3 3 0 0 3 3 3 0 Laminin Domain II DUF948 PF06103.11 CAV17423.1 - 0.34 11.2 28.4 3.8 7.8 1.1 5.2 2 2 2 4 4 4 0 Bacterial protein of unknown function (DUF948) Seryl_tRNA_N PF02403.22 CAV17423.1 - 0.42 10.9 9.6 0.13 12.5 0.7 3.2 2 2 0 3 3 3 0 Seryl-tRNA synthetase N-terminal domain NPV_P10 PF05531.12 CAV17423.1 - 1.3 9.6 10.9 6.8 7.2 0.0 4.2 2 2 0 3 3 3 0 Nucleopolyhedrovirus P10 protein DUF1149 PF06619.11 CAV17423.1 - 2.7 8.3 7.5 0.61 10.4 1.5 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF1149) Alanine_zipper PF11839.8 CAV17423.1 - 5.1 7.5 16.5 0.1 12.9 0.8 3.9 2 1 2 4 4 4 0 Alanine-zipper, major outer membrane lipoprotein GlnE PF03710.15 CAV17424.1 - 5e-189 625.6 0.6 1.1e-94 316.6 0.0 3.0 3 0 0 3 3 3 2 Glutamate-ammonia ligase adenylyltransferase GlnD_UR_UTase PF08335.11 CAV17424.1 - 2.7e-51 173.5 9.3 3.4e-44 150.5 1.4 2.7 3 0 0 3 3 3 2 GlnD PII-uridylyltransferase PfkB PF00294.24 CAV17425.1 - 7e-49 166.8 0.3 1.1e-48 166.1 0.1 1.4 2 0 0 2 2 2 1 pfkB family carbohydrate kinase CTP_transf_like PF01467.26 CAV17425.1 - 2.5e-15 56.9 0.0 4.5e-15 56.1 0.0 1.4 1 0 0 1 1 1 1 Cytidylyltransferase-like Phos_pyr_kin PF08543.12 CAV17425.1 - 2.3e-08 33.7 0.0 1.1e-07 31.5 0.0 2.0 2 0 0 2 2 2 1 Phosphomethylpyrimidine kinase Carb_kinase PF01256.17 CAV17425.1 - 0.015 14.8 0.1 0.03 13.8 0.1 1.5 1 0 0 1 1 1 0 Carbohydrate kinase FAD_syn PF06574.12 CAV17425.1 - 0.022 14.7 0.0 0.058 13.3 0.0 1.8 1 0 0 1 1 1 0 FAD synthetase Pantoate_ligase PF02569.15 CAV17425.1 - 0.13 11.5 0.1 0.24 10.6 0.1 1.4 1 0 0 1 1 1 0 Pantoate-beta-alanine ligase OEP PF02321.18 CAV17426.1 - 6.1e-57 192.5 31.8 4.9e-30 104.7 9.8 2.1 2 0 0 2 2 2 2 Outer membrane efflux protein OMP_b-brl PF13505.6 CAV17426.1 - 0.087 12.9 3.7 0.81 9.8 0.1 2.8 2 1 0 2 2 2 0 Outer membrane protein beta-barrel domain Bac_surface_Ag PF01103.23 CAV17426.1 - 0.094 12.2 4.7 0.24 10.8 0.6 2.3 2 0 0 2 2 2 0 Surface antigen NUDIX PF00293.28 CAV17427.1 - 5.1e-10 39.5 0.0 7.6e-10 38.9 0.0 1.3 1 0 0 1 1 1 1 NUDIX domain Imm6 PF14434.6 CAV17427.1 - 0.02 14.8 0.0 0.031 14.2 0.0 1.3 1 0 0 1 1 1 0 Immunity protein Imm6 DUF1249 PF06853.12 CAV17428.1 - 1.9e-38 131.0 0.0 2.4e-38 130.7 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1249) Death_2 PF14786.6 CAV17428.1 - 0.17 11.8 0.0 0.3 11.0 0.0 1.4 1 1 0 1 1 1 0 Tube Death domain Metallophos PF00149.28 CAV17429.1 - 5.1e-16 59.8 1.1 7.9e-16 59.2 1.1 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 CAV17429.1 - 5.1e-10 39.8 0.3 7.7e-10 39.2 0.3 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain UPF0227 PF05728.12 CAV17430.1 - 2.3e-71 239.6 0.4 2.6e-71 239.4 0.4 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0227) Abhydrolase_6 PF12697.7 CAV17430.1 - 5.2e-06 27.2 0.0 0.00087 20.0 0.0 2.0 1 1 1 2 2 2 1 Alpha/beta hydrolase family Lipase_3 PF01764.25 CAV17430.1 - 0.0025 17.7 0.0 0.0041 17.0 0.0 1.4 1 0 0 1 1 1 1 Lipase (class 3) Hydrolase_4 PF12146.8 CAV17430.1 - 0.0026 17.1 0.1 0.01 15.1 0.0 2.0 2 1 0 2 2 2 1 Serine aminopeptidase, S33 Peptidase_S9 PF00326.21 CAV17430.1 - 0.0046 16.5 0.0 0.0063 16.0 0.0 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family HBM PF16591.5 CAV17430.1 - 0.02 14.3 0.3 0.039 13.4 0.0 1.5 2 0 0 2 2 2 0 Helical bimodular sensor domain Esterase PF00756.20 CAV17430.1 - 0.048 13.3 0.0 0.23 11.1 0.0 1.9 1 1 0 2 2 2 0 Putative esterase DUF915 PF06028.11 CAV17430.1 - 0.085 12.2 0.1 1.5 8.1 0.0 2.1 1 1 1 2 2 2 0 Alpha/beta hydrolase of unknown function (DUF915) Abhydrolase_1 PF00561.20 CAV17430.1 - 0.17 11.5 0.4 0.87 9.2 0.1 2.1 2 1 0 2 2 2 0 alpha/beta hydrolase fold DNA_gyraseB PF00204.25 CAV17431.1 - 5.3e-42 143.2 0.0 1.4e-41 141.9 0.0 1.7 2 0 0 2 2 2 1 DNA gyrase B DNA_gyraseB_C PF00986.21 CAV17431.1 - 3.9e-27 94.2 2.7 1e-26 92.9 1.9 2.0 2 0 0 2 2 2 1 DNA gyrase B subunit, carboxyl terminus HATPase_c PF02518.26 CAV17431.1 - 8.2e-19 68.2 0.2 1.5e-18 67.4 0.2 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Toprim PF01751.22 CAV17431.1 - 7.2e-11 42.2 0.0 2.3e-10 40.6 0.0 1.9 2 0 0 2 2 2 1 Toprim domain HATPase_c_3 PF13589.6 CAV17431.1 - 0.00011 22.1 0.1 0.00023 21.0 0.1 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase TOPRIM_C PF16898.5 CAV17431.1 - 0.00084 19.6 0.0 0.0015 18.8 0.0 1.3 1 0 0 1 1 1 1 C-terminal associated domain of TOPRIM DUF993 PF06187.11 CAV17431.1 - 0.058 12.3 0.0 0.1 11.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF993) DNA_topoisoIV PF00521.20 CAV17432.1 - 1.8e-135 452.1 0.0 2.2e-135 451.9 0.0 1.1 1 0 0 1 1 1 1 DNA gyrase/topoisomerase IV, subunit A DNA_gyraseA_C PF03989.13 CAV17432.1 - 3.4e-12 45.6 0.0 9.5e-08 31.4 0.0 3.5 3 0 0 3 3 3 2 DNA gyrase C-terminal domain, beta-propeller Trypsin_2 PF13365.6 CAV17433.1 - 4.1e-33 115.4 2.2 6.9e-33 114.7 2.2 1.4 1 0 0 1 1 1 1 Trypsin-like peptidase domain Trypsin PF00089.26 CAV17433.1 - 9.3e-17 61.6 0.1 1.6e-16 60.8 0.1 1.3 1 0 0 1 1 1 1 Trypsin PDZ_2 PF13180.6 CAV17433.1 - 7.7e-14 51.8 3.2 1.1e-13 51.3 0.8 2.3 2 0 0 2 2 2 1 PDZ domain PDZ_6 PF17820.1 CAV17433.1 - 4.3e-07 29.7 0.6 4.3e-07 29.7 0.6 2.4 2 0 0 2 2 2 1 PDZ domain PDZ PF00595.24 CAV17433.1 - 2e-06 28.1 3.4 1.5e-05 25.2 2.7 2.6 2 1 0 2 2 2 1 PDZ domain Peptidase_S46 PF10459.9 CAV17433.1 - 5.2e-06 25.4 0.3 0.033 12.9 0.2 2.1 2 0 0 2 2 2 2 Peptidase S46 DUF31 PF01732.16 CAV17433.1 - 0.062 12.8 2.3 1.5 8.3 0.3 2.2 1 1 0 2 2 2 0 Putative peptidase (DUF31) Peptidase_S32 PF05579.13 CAV17433.1 - 0.073 12.3 2.3 0.39 9.9 2.3 1.9 1 1 0 1 1 1 0 Equine arteritis virus serine endopeptidase S32 Trypsin_2 PF13365.6 CAV17434.1 - 3.8e-30 105.8 0.2 7.1e-30 104.9 0.2 1.5 1 0 0 1 1 1 1 Trypsin-like peptidase domain PDZ_2 PF13180.6 CAV17434.1 - 2.3e-27 95.1 1.7 5.7e-17 61.8 0.2 2.6 2 0 0 2 2 2 2 PDZ domain PDZ PF00595.24 CAV17434.1 - 7.3e-26 90.3 4.1 7.5e-15 55.0 0.4 3.0 3 0 0 3 3 3 2 PDZ domain PDZ_6 PF17820.1 CAV17434.1 - 1.1e-21 76.4 1.3 1.9e-12 46.8 0.2 2.7 2 0 0 2 2 2 2 PDZ domain Trypsin PF00089.26 CAV17434.1 - 1.8e-16 60.6 0.0 4.4e-16 59.4 0.0 1.7 1 1 0 1 1 1 1 Trypsin PDZ_1 PF12812.7 CAV17434.1 - 2e-05 24.5 0.1 0.0006 19.8 0.0 2.4 2 0 0 2 2 2 1 PDZ-like domain GRASP55_65 PF04495.14 CAV17434.1 - 3.3e-05 24.2 0.0 0.011 16.0 0.0 2.4 1 1 1 2 2 2 2 GRASP55/65 PDZ-like domain Tricorn_PDZ PF14685.6 CAV17434.1 - 0.00054 19.9 1.7 0.068 13.1 0.1 3.4 3 1 0 3 3 3 1 Tricorn protease PDZ domain Peptidase_S46 PF10459.9 CAV17434.1 - 0.054 12.1 1.1 0.14 10.8 0.9 1.6 2 0 0 2 2 2 0 Peptidase S46 PDZ_3 PF17815.1 CAV17434.1 - 0.16 11.8 0.0 0.86 9.5 0.0 2.0 1 1 1 2 2 2 0 PDZ domain DUF4115 PF13464.6 CAV17434.1 - 0.19 11.9 4.9 21 5.4 0.6 4.4 3 2 2 5 5 5 0 Domain of unknown function (DUF4115) DUF1043 PF06295.12 CAV17435.1 - 2.8e-44 150.1 1.1 3.3e-44 149.8 1.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1043) PspA_IM30 PF04012.12 CAV17435.1 - 0.003 17.2 0.5 0.003 17.2 0.5 1.4 2 0 0 2 2 2 1 PspA/IM30 family YtxH PF12732.7 CAV17435.1 - 0.017 15.7 4.0 0.19 12.3 4.0 2.4 1 1 0 1 1 1 0 YtxH-like protein Jnk-SapK_ap_N PF09744.9 CAV17435.1 - 0.029 14.6 1.3 0.045 14.0 1.3 1.3 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 Dor1 PF04124.12 CAV17435.1 - 0.041 12.6 2.4 0.05 12.3 2.4 1.1 1 0 0 1 1 1 0 Dor1-like family DUF1729 PF08354.10 CAV17435.1 - 0.055 12.4 0.5 0.19 10.6 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF1729) DUF1726 PF08351.11 CAV17435.1 - 0.079 12.9 0.0 0.12 12.3 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1726) Glt_symporter PF03616.14 CAV17435.1 - 0.088 11.5 0.0 0.13 10.9 0.0 1.1 1 0 0 1 1 1 0 Sodium/glutamate symporter RRF PF01765.19 CAV17435.1 - 0.13 12.2 5.0 7.2 6.5 5.0 2.0 1 1 0 1 1 1 0 Ribosome recycling factor SCIMP PF15050.6 CAV17435.1 - 0.18 12.3 0.7 0.27 11.7 0.5 1.4 1 1 0 1 1 1 0 SCIMP protein DUF4472 PF14739.6 CAV17435.1 - 1.3 9.8 7.2 0.73 10.6 2.8 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4472) AFG1_ATPase PF03969.16 CAV17436.1 - 6.8e-154 512.1 0.6 7.6e-154 512.0 0.6 1.0 1 0 0 1 1 1 1 AFG1-like ATPase Bac_DnaA PF00308.18 CAV17436.1 - 0.0059 16.5 0.1 0.31 10.9 0.0 2.3 2 0 0 2 2 2 1 Bacterial dnaA protein WhiA_N PF10298.9 CAV17436.1 - 0.095 12.8 0.0 0.32 11.1 0.0 1.9 2 0 0 2 2 2 0 WhiA N-terminal LAGLIDADG-like domain Ribosomal_L13 PF00572.18 CAV17437.1 - 9.4e-57 190.7 0.2 1.1e-56 190.5 0.2 1.0 1 0 0 1 1 1 1 Ribosomal protein L13 DUF3659 PF12396.8 CAV17437.1 - 0.03 14.3 0.0 0.055 13.4 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3659) Ribosomal_S9 PF00380.19 CAV17438.1 - 1.4e-45 154.7 0.2 1.6e-45 154.5 0.2 1.0 1 0 0 1 1 1 1 Ribosomal protein S9/S16 Flg_hook PF02120.16 CAV17438.1 - 0.084 12.8 0.0 0.12 12.3 0.0 1.2 1 0 0 1 1 1 0 Flagellar hook-length control protein FliK UCR_Fe-S_N PF10399.9 CAV17439.1 - 1.1e-14 53.4 1.2 1.7e-14 52.8 1.2 1.3 1 0 0 1 1 1 1 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal Rieske PF00355.26 CAV17439.1 - 2.1e-12 46.8 0.0 6.9e-12 45.1 0.0 1.7 1 1 0 1 1 1 1 Rieske [2Fe-2S] domain Tudor_4 PF18358.1 CAV17439.1 - 0.12 11.9 0.1 0.2 11.3 0.1 1.3 1 0 0 1 1 1 0 Histone methyltransferase Tudor domain Cytochrome_B PF00033.19 CAV17440.1 - 3.5e-66 222.7 17.1 3.5e-66 222.7 17.1 1.8 2 0 0 2 2 2 1 Cytochrome b/b6/petB Cytochrom_B_N_2 PF13631.6 CAV17440.1 - 1.5e-41 142.2 5.7 1.5e-41 142.2 5.7 2.0 2 0 0 2 2 2 1 Cytochrome b(N-terminal)/b6/petB Cytochrom_B_C PF00032.17 CAV17440.1 - 3.9e-40 136.3 2.4 3.9e-40 136.3 2.4 3.6 4 1 0 4 4 4 1 Cytochrome b(C-terminal)/b6/petD Tetraspanin PF00335.20 CAV17440.1 - 2.9 7.5 16.7 6.4 6.4 4.3 3.0 3 0 0 3 3 3 0 Tetraspanin family Cytochrom_C1 PF02167.15 CAV17441.1 - 3.2e-18 66.3 1.9 1.9e-15 57.2 1.9 2.8 1 1 0 1 1 1 1 Cytochrome C1 family Cytochrom_C PF00034.21 CAV17441.1 - 0.037 15.2 0.4 0.097 13.8 0.3 1.9 2 1 0 2 2 2 0 Cytochrome c Cytochrome_CBB3 PF13442.6 CAV17441.1 - 0.07 13.5 0.0 0.17 12.3 0.0 1.7 1 0 0 1 1 1 0 Cytochrome C oxidase, cbb3-type, subunit III DUF4381 PF14316.6 CAV17441.1 - 0.19 12.0 1.1 0.34 11.2 0.4 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4381) GST_N_3 PF13417.6 CAV17442.1 - 1.4e-16 60.6 0.1 2.2e-16 60.0 0.1 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.20 CAV17442.1 - 4.5e-15 55.7 0.0 7.4e-15 55.1 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 CAV17442.1 - 6.3e-12 45.6 0.1 1.2e-11 44.7 0.1 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 CAV17442.1 - 1.2e-07 31.9 0.0 1.9e-07 31.2 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 CAV17442.1 - 0.0012 18.8 0.0 0.0021 18.1 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Glutaredoxin PF00462.24 CAV17442.1 - 0.0026 17.9 0.0 0.0046 17.1 0.0 1.4 1 0 0 1 1 1 1 Glutaredoxin SspB PF04386.13 CAV17443.1 - 9.9e-41 139.3 0.0 1.1e-40 139.1 0.0 1.0 1 0 0 1 1 1 1 Stringent starvation protein B GRAM PF02893.20 CAV17443.1 - 0.1 12.5 0.0 0.14 12.1 0.0 1.2 1 0 0 1 1 1 0 GRAM domain BON PF04972.17 CAV17444.1 - 3.6e-28 97.7 1.7 5.5e-14 52.2 0.4 2.1 2 0 0 2 2 2 2 BON domain SIS_2 PF13580.6 CAV17445.1 - 9.4e-34 116.4 0.9 1.1e-33 116.1 0.9 1.1 1 0 0 1 1 1 1 SIS domain SIS PF01380.22 CAV17445.1 - 6e-07 29.4 0.5 1.6e-06 28.0 0.1 1.9 2 0 0 2 2 2 1 SIS domain HobA PF12163.8 CAV17445.1 - 0.11 12.0 0.0 0.14 11.7 0.0 1.2 1 0 0 1 1 1 0 DNA replication regulator UPF0102 PF02021.17 CAV17446.1 - 2.2e-25 88.7 0.2 2.8e-25 88.3 0.2 1.1 1 0 0 1 1 1 1 Uncharacterised protein family UPF0102 DUF234 PF03008.14 CAV17446.1 - 0.00089 19.7 0.1 0.0031 18.0 0.0 1.9 1 1 1 2 2 2 1 Archaea bacterial proteins of unknown function NERD PF08378.11 CAV17446.1 - 0.0011 19.4 0.1 0.0019 18.7 0.1 1.3 1 1 0 1 1 1 1 Nuclease-related domain LppC PF04348.13 CAV17447.1 - 2.7e-170 567.7 20.7 3.2e-170 567.5 20.7 1.0 1 0 0 1 1 1 1 LppC putative lipoprotein DUF4880 PF16220.5 CAV17447.1 - 0.011 15.7 1.7 0.16 11.9 0.0 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4880) VasI PF11319.8 CAV17447.1 - 0.049 13.3 0.2 0.12 12.0 0.2 1.7 1 0 0 1 1 1 0 Type VI secretion system VasI, EvfG, VC_A0118 TP_methylase PF00590.20 CAV17448.1 - 1.1e-29 104.0 0.0 1.4e-29 103.6 0.0 1.2 1 0 0 1 1 1 1 Tetrapyrrole (Corrin/Porphyrin) Methylases Methyltransf_5 PF01795.19 CAV17449.1 - 7.6e-108 360.7 0.0 8.6e-108 360.5 0.0 1.0 1 0 0 1 1 1 1 MraW methylase family Methyltransf_31 PF13847.6 CAV17449.1 - 0.00069 19.4 0.0 0.016 15.0 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 CAV17449.1 - 0.0084 16.8 0.0 0.078 13.7 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain FtsJ PF01728.19 CAV17449.1 - 0.082 13.0 0.0 0.2 11.7 0.0 1.8 1 1 0 1 1 1 0 FtsJ-like methyltransferase FtsL PF04999.13 CAV17450.1 - 1.7e-35 120.9 0.2 1.9e-35 120.7 0.2 1.0 1 0 0 1 1 1 1 Cell division protein FtsL SinI PF08671.10 CAV17450.1 - 0.12 12.2 1.4 0.22 11.4 1.4 1.4 1 0 0 1 1 1 0 Anti-repressor SinI Transpeptidase PF00905.22 CAV17451.1 - 4.6e-77 259.2 0.2 5.9e-77 258.9 0.2 1.1 1 0 0 1 1 1 1 Penicillin binding protein transpeptidase domain PBP_dimer PF03717.15 CAV17451.1 - 6e-22 78.8 0.4 2.1e-20 73.8 0.4 2.4 1 1 0 1 1 1 1 Penicillin-binding Protein dimerisation domain Mur_ligase_M PF08245.12 CAV17452.1 - 1.4e-51 175.2 0.4 2.9e-51 174.2 0.4 1.5 1 0 0 1 1 1 1 Mur ligase middle domain Mur_ligase_C PF02875.21 CAV17452.1 - 1.8e-22 79.4 0.0 1.3e-21 76.6 0.0 2.4 2 0 0 2 2 2 1 Mur ligase family, glutamate ligase domain Mur_ligase PF01225.25 CAV17452.1 - 1.4e-11 44.6 0.2 4.3e-11 43.0 0.1 1.9 2 0 0 2 2 2 1 Mur ligase family, catalytic domain Mur_ligase_M PF08245.12 CAV17453.1 - 2.2e-48 164.8 0.2 4.5e-48 163.8 0.2 1.5 1 0 0 1 1 1 1 Mur ligase middle domain Mur_ligase_C PF02875.21 CAV17453.1 - 2.9e-15 56.3 0.1 2e-14 53.6 0.0 2.4 3 0 0 3 3 3 1 Mur ligase family, glutamate ligase domain Mur_ligase PF01225.25 CAV17453.1 - 3.2e-09 37.0 0.2 2.1e-08 34.4 0.0 2.5 3 0 0 3 3 3 1 Mur ligase family, catalytic domain Glycos_transf_4 PF00953.21 CAV17454.1 - 2.7e-37 128.2 16.3 2.7e-37 128.2 16.3 2.5 3 0 0 3 3 3 1 Glycosyl transferase family 4 MraY_sig1 PF10555.9 CAV17454.1 - 5.6e-06 25.6 2.5 5.6e-06 25.6 2.5 2.5 2 0 0 2 2 2 1 Phospho-N-acetylmuramoyl-pentapeptide-transferase signature 1 Ndc1_Nup PF09531.10 CAV17454.1 - 0.0011 17.7 0.9 0.0023 16.7 0.9 1.4 1 0 0 1 1 1 1 Nucleoporin protein Ndc1-Nup CoxIIa PF08113.11 CAV17454.1 - 4.7 7.1 10.5 6 6.8 1.9 4.2 3 0 0 3 3 3 0 Cytochrome c oxidase subunit IIa family Mur_ligase_M PF08245.12 CAV17455.1 - 1.4e-28 100.2 0.0 2.2e-28 99.6 0.0 1.3 1 0 0 1 1 1 1 Mur ligase middle domain Mur_ligase_C PF02875.21 CAV17455.1 - 1.9e-06 28.0 0.0 4.9e-06 26.7 0.0 1.7 1 0 0 1 1 1 1 Mur ligase family, glutamate ligase domain NAD_binding_7 PF13241.6 CAV17455.1 - 0.0031 17.9 0.0 0.0089 16.4 0.0 1.8 2 0 0 2 2 2 1 Putative NAD(P)-binding 3Beta_HSD PF01073.19 CAV17455.1 - 0.0054 15.8 0.0 0.0083 15.2 0.0 1.3 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_9 PF13454.6 CAV17455.1 - 0.0063 16.5 0.0 0.012 15.6 0.0 1.5 1 0 0 1 1 1 1 FAD-NAD(P)-binding TrkA_N PF02254.18 CAV17455.1 - 0.042 14.1 0.0 0.12 12.7 0.0 1.8 1 0 0 1 1 1 0 TrkA-N domain DAO PF01266.24 CAV17455.1 - 0.045 13.3 0.0 0.07 12.7 0.0 1.3 1 0 0 1 1 1 0 FAD dependent oxidoreductase Malectin_like PF12819.7 CAV17455.1 - 0.21 10.7 0.0 0.49 9.5 0.0 1.5 2 0 0 2 2 2 0 Malectin-like domain FTSW_RODA_SPOVE PF01098.19 CAV17456.1 - 7e-113 377.3 28.1 8.6e-113 377.0 28.1 1.0 1 0 0 1 1 1 1 Cell cycle protein Glyco_transf_28 PF03033.20 CAV17457.1 - 3.3e-48 163.3 0.2 5.6e-48 162.5 0.2 1.4 1 0 0 1 1 1 1 Glycosyltransferase family 28 N-terminal domain Glyco_tran_28_C PF04101.16 CAV17457.1 - 3.6e-35 121.4 1.6 5.3e-35 120.8 1.6 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain Glyco_transf_4 PF13439.6 CAV17457.1 - 2.9e-07 30.6 0.0 5.9e-07 29.6 0.0 1.5 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_trans_4_4 PF13579.6 CAV17457.1 - 3.5e-06 27.5 0.1 2.3e-05 24.9 0.0 2.1 2 1 0 2 2 2 1 Glycosyl transferase 4-like domain Glyco_trans_1_4 PF13692.6 CAV17457.1 - 0.00016 22.1 0.7 0.00053 20.4 0.1 2.3 3 1 0 3 3 3 1 Glycosyl transferases group 1 Glyco_trans_4_2 PF13477.6 CAV17457.1 - 0.00083 19.4 0.0 0.0015 18.5 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase 4-like Phage_Treg PF04761.12 CAV17457.1 - 0.096 12.8 0.5 0.19 11.8 0.5 1.4 1 0 0 1 1 1 0 Lactococcus bacteriophage putative transcription regulator DUF2798 PF11391.8 CAV17457.1 - 0.19 11.8 1.4 0.25 11.4 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2798) Mur_ligase_M PF08245.12 CAV17458.1 - 1.3e-28 100.3 0.0 2.3e-28 99.5 0.0 1.4 1 0 0 1 1 1 1 Mur ligase middle domain Mur_ligase PF01225.25 CAV17458.1 - 2.1e-27 95.3 0.5 4.8e-27 94.1 0.5 1.7 1 0 0 1 1 1 1 Mur ligase family, catalytic domain Mur_ligase_C PF02875.21 CAV17458.1 - 1.7e-22 79.4 0.1 1.6e-21 76.4 0.0 2.6 3 0 0 3 3 3 1 Mur ligase family, glutamate ligase domain FtsQ PF03799.15 CAV17459.1 - 5.3e-24 85.3 0.2 7.2e-24 84.9 0.2 1.2 1 0 0 1 1 1 1 Cell division protein FtsQ POTRA_1 PF08478.10 CAV17459.1 - 4e-12 46.3 0.0 7.7e-12 45.3 0.0 1.5 1 0 0 1 1 1 1 POTRA domain, FtsQ-type SH3_13 PF18335.1 CAV17459.1 - 0.095 12.5 0.1 0.18 11.7 0.1 1.5 1 0 0 1 1 1 0 ATP-dependent RecD-like DNA helicase SH3 domain FtsA PF14450.6 CAV17460.1 - 2.3e-33 114.7 2.3 1.7e-23 83.0 0.0 2.3 2 1 0 2 2 2 2 Cell division protein FtsA SHS2_FTSA PF02491.20 CAV17460.1 - 1.7e-28 98.8 1.0 4e-28 97.6 1.0 1.7 1 0 0 1 1 1 1 SHS2 domain inserted in FTSA PilM_2 PF11104.8 CAV17460.1 - 2.1e-10 40.1 0.1 2.3e-07 30.2 0.1 2.4 2 1 0 2 2 2 2 Type IV pilus assembly protein PilM; MreB_Mbl PF06723.13 CAV17460.1 - 7.1e-09 34.9 1.7 2.9e-08 32.9 0.3 2.4 1 1 0 2 2 2 1 MreB/Mbl protein HSP70 PF00012.20 CAV17460.1 - 0.00057 18.2 3.0 0.086 11.0 0.1 2.6 3 0 0 3 3 3 2 Hsp70 protein DDR PF08841.10 CAV17460.1 - 0.0031 16.5 0.2 0.005 15.9 0.2 1.5 1 0 0 1 1 1 1 Diol dehydratase reactivase ATPase-like domain Actin PF00022.19 CAV17460.1 - 0.012 14.2 0.3 0.26 9.9 0.1 2.3 1 1 1 2 2 2 0 Actin ANF_receptor PF01094.28 CAV17460.1 - 0.029 13.5 0.0 0.038 13.1 0.0 1.1 1 0 0 1 1 1 0 Receptor family ligand binding region Tubulin PF00091.25 CAV17461.1 - 9.2e-40 136.9 0.7 1.7e-39 136.1 0.7 1.4 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain FtsZ_C PF12327.8 CAV17461.1 - 4.2e-37 126.3 3.0 1.4e-36 124.6 3.0 2.0 1 0 0 1 1 1 1 FtsZ family, C-terminal domain NAD_binding_10 PF13460.6 CAV17461.1 - 0.003 17.5 0.4 0.003 17.5 0.4 2.1 2 1 0 2 2 2 1 NAD(P)H-binding NmrA PF05368.13 CAV17461.1 - 0.045 13.3 0.9 0.54 9.8 0.3 2.4 1 1 1 2 2 2 0 NmrA-like family Tubulin_2 PF13809.6 CAV17461.1 - 0.52 9.4 9.6 6.7 5.8 4.4 2.8 1 1 1 2 2 2 0 Tubulin like LpxC PF03331.13 CAV17462.1 - 2.7e-107 358.3 0.0 3.1e-107 358.1 0.0 1.0 1 0 0 1 1 1 1 UDP-3-O-acyl N-acetylglycosamine deacetylase SecA_DEAD PF07517.14 CAV17463.1 - 7.7e-133 442.2 0.8 1.6e-132 441.2 0.8 1.5 1 0 0 1 1 1 1 SecA DEAD-like domain SecA_SW PF07516.13 CAV17463.1 - 1.9e-65 220.7 7.8 3.7e-65 219.7 6.6 2.2 2 0 0 2 2 2 1 SecA Wing and Scaffold domain SecA_PP_bind PF01043.20 CAV17463.1 - 3.1e-38 130.8 0.2 8.8e-38 129.4 0.2 1.8 1 0 0 1 1 1 1 SecA preprotein cross-linking domain SEC-C PF02810.15 CAV17463.1 - 2.2e-10 40.3 9.7 3.5e-10 39.6 9.7 1.3 1 0 0 1 1 1 1 SEC-C motif DUF2175 PF09943.9 CAV17463.1 - 0.0066 16.7 0.7 0.0066 16.7 0.7 2.9 3 0 0 3 3 3 1 Uncharacterized protein conserved in archaea (DUF2175) DEAD PF00270.29 CAV17463.1 - 0.0082 15.9 0.0 0.029 14.1 0.0 1.9 1 0 0 1 1 1 1 DEAD/DEAH box helicase RR_TM4-6 PF06459.12 CAV17463.1 - 0.085 12.7 2.6 0.22 11.3 2.6 1.7 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF4407 PF14362.6 CAV17463.1 - 0.14 11.5 7.2 0.31 10.4 7.2 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) CorA PF01544.18 CAV17463.1 - 1.4 8.2 12.9 0.44 9.8 1.3 3.3 3 0 0 3 3 3 0 CorA-like Mg2+ transporter protein SlyX PF04102.12 CAV17463.1 - 2.7 8.7 7.8 6.4 7.5 6.0 2.7 2 0 0 2 2 2 0 SlyX HTH_28 PF13518.6 CAV17464.1 - 0.00018 21.6 0.1 0.0004 20.5 0.1 1.6 1 0 0 1 1 1 1 Helix-turn-helix domain Sugarporin_N PF11471.8 CAV17464.1 - 0.0027 17.6 1.8 0.0044 16.9 1.8 1.3 1 0 0 1 1 1 1 Maltoporin periplasmic N-terminal extension rve PF00665.26 CAV17465.1 - 1.8e-26 92.6 0.1 6.2e-26 90.9 0.0 1.8 2 0 0 2 2 2 1 Integrase core domain rve_3 PF13683.6 CAV17465.1 - 2.6e-19 68.8 0.0 5.3e-19 67.8 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain DDE_Tnp_IS240 PF13610.6 CAV17465.1 - 0.0001 22.5 0.2 0.00018 21.7 0.2 1.4 1 0 0 1 1 1 1 DDE domain HTH_21 PF13276.6 CAV17465.1 - 0.015 15.4 1.6 0.043 14.0 1.0 2.1 2 0 0 2 2 2 0 HTH-like domain rve_2 PF13333.6 CAV17465.1 - 0.051 13.7 0.1 0.1 12.8 0.1 1.5 1 0 0 1 1 1 0 Integrase core domain RlmM_FDX PF18125.1 CAV17465.1 - 0.13 12.8 0.0 0.47 11.0 0.0 1.9 1 0 0 1 1 1 0 RlmM ferredoxin-like domain NUDIX PF00293.28 CAV17466.1 - 8.2e-22 77.6 0.2 1.1e-21 77.3 0.2 1.1 1 0 0 1 1 1 1 NUDIX domain NUDIX_4 PF14815.6 CAV17466.1 - 1.3e-17 63.8 0.0 1.4e-17 63.6 0.0 1.0 1 0 0 1 1 1 1 NUDIX domain DapB_C PF05173.14 CAV17467.1 - 1.1e-43 148.1 0.2 1.7e-43 147.5 0.2 1.3 1 0 0 1 1 1 1 Dihydrodipicolinate reductase, C-terminus DapB_N PF01113.20 CAV17467.1 - 5.6e-39 133.1 0.4 1.9e-38 131.4 0.2 1.9 2 0 0 2 2 2 1 Dihydrodipicolinate reductase, N-terminus Sacchrp_dh_NADP PF03435.18 CAV17467.1 - 0.001 19.3 0.2 0.0031 17.8 0.1 1.9 2 0 0 2 2 2 1 Saccharopine dehydrogenase NADP binding domain NAD_binding_10 PF13460.6 CAV17467.1 - 0.06 13.2 0.2 0.093 12.6 0.2 1.4 1 0 0 1 1 1 0 NAD(P)H-binding RGCC PF15151.6 CAV17467.1 - 0.16 12.2 0.0 0.28 11.4 0.0 1.4 1 0 0 1 1 1 0 Response gene to complement 32 protein family CPSase_sm_chain PF00988.22 CAV17468.1 - 2.2e-54 182.7 0.1 3.9e-54 181.9 0.1 1.4 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase small chain, CPSase domain GATase PF00117.28 CAV17468.1 - 1.7e-47 161.6 0.0 2.6e-47 161.1 0.0 1.2 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.13 CAV17468.1 - 3.8e-05 23.5 0.1 0.00023 21.0 0.1 2.2 1 1 0 1 1 1 1 Peptidase C26 DJ-1_PfpI PF01965.24 CAV17468.1 - 0.00047 20.0 0.0 0.0028 17.5 0.0 2.0 1 1 0 2 2 2 1 DJ-1/PfpI family CPSase_L_D2 PF02786.17 CAV17469.1 - 1.9e-111 370.6 0.3 2e-72 243.1 0.0 2.3 2 0 0 2 2 2 2 Carbamoyl-phosphate synthase L chain, ATP binding domain CPSase_L_D3 PF02787.19 CAV17469.1 - 9e-42 142.3 0.1 2.8e-40 137.5 0.1 2.5 2 0 0 2 2 2 1 Carbamoyl-phosphate synthetase large chain, oligomerisation domain MGS PF02142.22 CAV17469.1 - 1e-16 60.9 0.1 9.9e-16 57.7 0.1 2.8 2 0 0 2 2 2 1 MGS-like domain ATP-grasp PF02222.22 CAV17469.1 - 1e-12 48.0 0.0 7.2e-07 28.9 0.1 2.4 2 0 0 2 2 2 2 ATP-grasp domain ATP-grasp_3 PF02655.14 CAV17469.1 - 2.2e-12 47.3 0.2 4.8e-07 30.0 0.1 2.8 2 0 0 2 2 2 2 ATP-grasp domain ATPgrasp_Ter PF15632.6 CAV17469.1 - 1.8e-10 40.6 0.0 6.3e-06 26.0 0.0 2.7 2 0 0 2 2 2 2 ATP-grasp in the biosynthetic pathway with Ter operon Dala_Dala_lig_C PF07478.13 CAV17469.1 - 2.4e-09 37.0 0.0 7.9e-05 22.3 0.1 2.4 2 0 0 2 2 2 2 D-ala D-ala ligase C-terminus ATP-grasp_4 PF13535.6 CAV17469.1 - 1.1e-08 34.9 0.0 0.0021 17.7 0.0 4.1 3 2 0 3 3 3 2 ATP-grasp domain CoA_binding_2 PF13380.6 CAV17469.1 - 0.00019 21.9 0.0 4.9 7.7 0.0 4.3 3 1 0 3 3 3 1 CoA binding domain PriA_C PF18074.1 CAV17469.1 - 0.0038 18.0 0.0 10 7.0 0.0 3.7 3 0 0 3 3 3 1 Primosomal protein N C-terminal domain ATP-grasp_5 PF13549.6 CAV17469.1 - 0.068 12.6 0.0 23 4.4 0.0 3.3 3 0 0 3 3 3 0 ATP-grasp domain Epimerase PF01370.21 CAV17469.1 - 0.08 12.4 0.0 0.95 8.9 0.0 2.2 2 0 0 2 2 2 0 NAD dependent epimerase/dehydratase family TauE PF01925.19 CAV17470.1 - 1.5e-42 145.8 29.2 1.9e-42 145.5 29.2 1.0 1 0 0 1 1 1 1 Sulfite exporter TauE/SafE Na_Pi_cotrans PF02690.15 CAV17470.1 - 0.00036 20.7 1.7 0.00036 20.7 1.7 2.7 2 1 0 2 2 2 1 Na+/Pi-cotransporter DUF1294 PF06961.13 CAV17470.1 - 2.2 8.6 8.5 6.6 7.1 0.3 3.8 4 0 0 4 4 4 0 Protein of unknown function (DUF1294) LysR_substrate PF03466.20 CAV17471.1 - 3.2e-14 52.8 0.0 4.9e-14 52.2 0.0 1.3 1 0 0 1 1 1 1 LysR substrate binding domain HTH_1 PF00126.27 CAV17471.1 - 1.9e-13 50.1 0.1 1.6e-12 47.2 0.0 2.2 2 1 1 3 3 3 1 Bacterial regulatory helix-turn-helix protein, lysR family UPF0126 PF03458.13 CAV17472.1 - 2e-41 139.7 27.3 1.9e-22 78.9 10.9 2.4 2 1 0 2 2 2 2 UPF0126 domain TRIC PF05197.13 CAV17472.1 - 0.023 14.3 1.4 0.036 13.7 1.1 1.6 1 1 0 1 1 1 0 TRIC channel Glyco_hydro_42C PF08533.10 CAV17472.1 - 0.086 12.6 0.1 4 7.2 0.0 2.3 2 0 0 2 2 2 0 Beta-galactosidase C-terminal domain Peripla_BP_2 PF01497.18 CAV17473.1 - 5.5e-24 85.0 0.1 6.8e-24 84.7 0.1 1.1 1 0 0 1 1 1 1 Periplasmic binding protein CobD_Cbib PF03186.13 CAV17474.1 - 1e-33 116.7 1.2 1.2e-33 116.5 1.2 1.0 1 0 0 1 1 1 1 CobD/Cbib protein PNP_UDP_1 PF01048.20 CAV17475.1 - 7.4e-50 169.4 4.3 8.4e-50 169.2 4.3 1.0 1 0 0 1 1 1 1 Phosphorylase superfamily Bac_GH3_C PF18034.1 CAV17475.1 - 0.064 13.0 0.0 0.11 12.3 0.0 1.3 1 0 0 1 1 1 0 Bacterial Glycosyl hydrolase family 3 C-terminal domain DUF1499 PF07386.11 CAV17476.1 - 9.7e-24 84.2 0.1 1.1e-23 84.0 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1499) ARPC4 PF05856.12 CAV17476.1 - 0.12 12.0 0.0 0.17 11.4 0.0 1.2 1 0 0 1 1 1 0 ARP2/3 complex 20 kDa subunit (ARPC4) LPAM_1 PF08139.12 CAV17476.1 - 2.8 8.6 4.7 5.7 7.6 4.7 1.6 1 0 0 1 1 1 0 Prokaryotic membrane lipoprotein lipid attachment site Fer4_20 PF14691.6 CAV17477.1 - 1.1e-38 131.4 0.8 1.8e-38 130.8 0.8 1.3 1 0 0 1 1 1 1 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster Pyr_redox_2 PF07992.14 CAV17477.1 - 2.7e-24 85.9 0.2 3.8e-24 85.4 0.2 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 CAV17477.1 - 1.8e-10 41.2 3.2 8.9e-06 26.2 0.1 3.0 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 CAV17477.1 - 2.6e-09 36.8 1.0 0.00039 19.8 0.0 2.8 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FMO-like PF00743.19 CAV17477.1 - 5.1e-07 28.5 0.0 0.00033 19.2 0.0 2.2 1 1 0 2 2 2 2 Flavin-binding monooxygenase-like NAD_binding_8 PF13450.6 CAV17477.1 - 6.2e-07 29.6 0.1 1.5e-06 28.3 0.1 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain NAD_binding_7 PF13241.6 CAV17477.1 - 7.9e-07 29.5 0.8 0.0034 17.8 0.2 2.9 2 1 0 2 2 2 2 Putative NAD(P)-binding FAD_binding_3 PF01494.19 CAV17477.1 - 9.1e-07 28.4 0.1 1.9e-06 27.4 0.1 1.5 1 0 0 1 1 1 1 FAD binding domain FAD_oxidored PF12831.7 CAV17477.1 - 1.7e-06 27.7 0.0 3.1e-06 26.8 0.0 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase Thi4 PF01946.17 CAV17477.1 - 8.1e-06 25.3 0.3 1.6e-05 24.3 0.1 1.5 2 0 0 2 2 2 1 Thi4 family FAD_binding_2 PF00890.24 CAV17477.1 - 1.8e-05 24.1 1.0 0.031 13.4 0.5 2.2 2 0 0 2 2 2 2 FAD binding domain Shikimate_DH PF01488.20 CAV17477.1 - 2.4e-05 24.4 0.0 0.047 13.7 0.0 2.7 3 0 0 3 3 2 2 Shikimate / quinate 5-dehydrogenase 2-Hacid_dh_C PF02826.19 CAV17477.1 - 5.9e-05 22.5 0.0 0.00053 19.4 0.0 2.2 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain AlaDh_PNT_C PF01262.21 CAV17477.1 - 0.00023 20.5 1.1 0.026 13.8 0.1 2.8 2 1 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain IlvN PF07991.12 CAV17477.1 - 0.00037 20.1 0.0 0.23 11.0 0.0 2.5 2 0 0 2 2 2 2 Acetohydroxy acid isomeroreductase, NADPH-binding domain HI0933_like PF03486.14 CAV17477.1 - 0.00056 18.7 0.3 0.00056 18.7 0.3 1.5 2 0 0 2 2 2 1 HI0933-like protein NAD_binding_9 PF13454.6 CAV17477.1 - 0.0033 17.4 0.7 0.058 13.4 0.3 2.3 2 0 0 2 2 2 1 FAD-NAD(P)-binding K_oxygenase PF13434.6 CAV17477.1 - 0.0079 15.4 0.0 4.1 6.4 0.0 3.1 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) F420_oxidored PF03807.17 CAV17477.1 - 0.01 16.4 0.8 5.8 7.6 0.1 4.0 4 1 0 4 4 4 0 NADP oxidoreductase coenzyme F420-dependent DAO PF01266.24 CAV17477.1 - 0.014 15.0 1.4 0.12 11.9 0.9 2.2 2 0 0 2 2 2 0 FAD dependent oxidoreductase Glu_dehyd_C PF16912.5 CAV17477.1 - 0.021 14.3 0.0 0.085 12.3 0.0 1.9 2 0 0 2 2 2 0 Glucose dehydrogenase C-terminus GIDA PF01134.22 CAV17477.1 - 0.037 13.1 0.1 0.056 12.5 0.1 1.2 1 0 0 1 1 1 0 Glucose inhibited division protein A Fer4_7 PF12838.7 CAV17477.1 - 0.077 13.6 0.3 0.077 13.6 0.3 2.4 2 0 0 2 2 2 0 4Fe-4S dicluster domain NAD_Gly3P_dh_N PF01210.23 CAV17477.1 - 0.11 12.4 0.0 0.27 11.2 0.0 1.7 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus Glu_synthase PF01645.17 CAV17478.1 - 3.1e-153 510.3 0.0 2.5e-152 507.3 0.0 2.0 2 0 0 2 2 2 1 Conserved region in glutamate synthase GATase_2 PF00310.21 CAV17478.1 - 7.8e-103 344.4 0.0 1.3e-102 343.7 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferases class-II Glu_syn_central PF04898.14 CAV17478.1 - 4.3e-101 338.1 0.1 1.4e-100 336.4 0.0 1.8 2 0 0 2 2 2 1 Glutamate synthase central domain GXGXG PF01493.19 CAV17478.1 - 1.1e-72 243.7 13.9 3.5e-72 242.0 12.7 2.1 2 0 0 2 2 2 1 GXGXG motif FMN_dh PF01070.18 CAV17478.1 - 0.00065 18.8 0.3 0.0017 17.5 0.3 1.6 1 0 0 1 1 1 1 FMN-dependent dehydrogenase GATase_2 PF00310.21 CAV17479.1 - 1.1e-69 235.2 0.0 1.4e-69 234.9 0.0 1.0 1 0 0 1 1 1 1 Glutamine amidotransferases class-II Fer4_20 PF14691.6 CAV17480.1 - 1.7e-24 85.8 1.1 2.9e-24 85.0 1.1 1.4 1 0 0 1 1 1 1 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster Pyr_redox_2 PF07992.14 CAV17480.1 - 6.5e-24 84.7 0.2 2e-23 83.1 0.2 1.8 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 CAV17480.1 - 8.4e-09 35.9 2.5 0.00022 21.7 0.1 3.1 3 1 0 3 3 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 CAV17480.1 - 5.1e-08 33.0 1.2 6.6e-08 32.7 0.1 1.8 2 0 0 2 2 1 1 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.14 CAV17480.1 - 1.2e-07 30.8 0.1 1.4e-06 27.3 0.1 2.3 3 0 0 3 3 3 1 HI0933-like protein Amino_oxidase PF01593.24 CAV17480.1 - 7.3e-07 28.8 0.6 1.2e-06 28.2 0.1 1.5 2 0 0 2 2 2 1 Flavin containing amine oxidoreductase Pyr_redox_3 PF13738.6 CAV17480.1 - 2.4e-06 27.0 0.4 0.0029 16.9 0.1 3.6 3 1 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 CAV17480.1 - 1.1e-05 24.7 1.4 1.6e-05 24.2 0.5 1.7 2 0 0 2 2 2 1 FAD binding domain FAD_oxidored PF12831.7 CAV17480.1 - 3.8e-05 23.2 0.2 0.0001 21.8 0.1 1.6 2 0 0 2 2 2 1 FAD dependent oxidoreductase FMO-like PF00743.19 CAV17480.1 - 4.3e-05 22.1 0.1 0.0047 15.4 0.0 2.1 2 0 0 2 2 2 1 Flavin-binding monooxygenase-like FAD_binding_3 PF01494.19 CAV17480.1 - 5.2e-05 22.7 0.0 8.9e-05 21.9 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain NAD_binding_7 PF13241.6 CAV17480.1 - 0.00016 22.1 0.0 0.1 13.1 0.1 2.5 2 0 0 2 2 2 1 Putative NAD(P)-binding AlaDh_PNT_C PF01262.21 CAV17480.1 - 0.0003 20.1 0.1 0.013 14.8 0.1 2.2 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain DJ-1_PfpI PF01965.24 CAV17480.1 - 0.00044 20.1 1.6 0.62 9.9 0.0 3.1 1 1 2 3 3 3 1 DJ-1/PfpI family DAO PF01266.24 CAV17480.1 - 0.0016 18.1 0.2 0.0016 18.1 0.2 2.3 2 1 0 2 2 2 1 FAD dependent oxidoreductase K_oxygenase PF13434.6 CAV17480.1 - 0.0028 16.9 0.0 0.72 8.9 0.0 2.3 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) Thi4 PF01946.17 CAV17480.1 - 0.0036 16.6 1.2 0.0047 16.2 0.1 1.7 2 0 0 2 2 2 1 Thi4 family TrkA_N PF02254.18 CAV17480.1 - 0.0057 16.9 0.2 0.063 13.5 0.0 2.4 2 0 0 2 2 2 1 TrkA-N domain AdoHcyase_NAD PF00670.21 CAV17480.1 - 0.0088 16.1 0.3 4.4 7.4 0.1 2.4 2 0 0 2 2 2 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 2-Hacid_dh_C PF02826.19 CAV17480.1 - 0.016 14.6 0.1 0.069 12.5 0.0 1.9 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_Gly3P_dh_N PF01210.23 CAV17480.1 - 0.016 15.2 0.0 0.029 14.4 0.0 1.5 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus Lycopene_cycl PF05834.12 CAV17480.1 - 0.016 14.2 0.1 0.066 12.3 0.2 1.8 2 0 0 2 2 2 0 Lycopene cyclase protein NAD_binding_9 PF13454.6 CAV17480.1 - 0.018 15.0 0.1 0.051 13.6 0.1 1.8 1 0 0 1 1 1 0 FAD-NAD(P)-binding YjeF_N PF03853.15 CAV17480.1 - 0.019 14.8 0.0 1.3 8.9 0.0 2.3 2 0 0 2 2 2 0 YjeF-related protein N-terminus F420_oxidored PF03807.17 CAV17480.1 - 0.025 15.1 1.6 0.55 10.9 0.1 3.6 5 0 0 5 5 4 0 NADP oxidoreductase coenzyme F420-dependent 3HCDH_N PF02737.18 CAV17480.1 - 0.026 14.4 0.1 0.051 13.5 0.1 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain GIDA PF01134.22 CAV17480.1 - 0.028 13.5 3.1 0.03 13.4 0.2 2.1 2 0 0 2 2 2 0 Glucose inhibited division protein A DUF364 PF04016.12 CAV17480.1 - 0.029 14.0 0.0 2.2 7.8 0.0 2.9 3 0 0 3 3 3 0 Putative heavy-metal chelation IlvN PF07991.12 CAV17480.1 - 0.029 13.9 1.1 0.074 12.6 0.1 2.1 2 0 0 2 2 2 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain Shikimate_DH PF01488.20 CAV17480.1 - 0.035 14.2 0.1 1.4 9.0 0.0 2.3 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase NAD_binding_2 PF03446.15 CAV17480.1 - 0.071 13.3 0.0 0.14 12.3 0.0 1.5 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase Fer4_7 PF12838.7 CAV17480.1 - 0.13 12.9 0.3 0.13 12.9 0.3 2.2 2 0 0 2 2 2 0 4Fe-4S dicluster domain GATase_2 PF00310.21 CAV17481.1 - 1.4e-184 613.7 0.0 2e-184 613.2 0.0 1.2 1 0 0 1 1 1 1 Glutamine amidotransferases class-II Glu_synthase PF01645.17 CAV17481.1 - 6.2e-151 502.7 0.1 3.2e-147 490.5 0.0 2.3 2 0 0 2 2 2 2 Conserved region in glutamate synthase Glu_syn_central PF04898.14 CAV17481.1 - 2.5e-117 391.3 0.0 4.5e-115 383.9 0.0 2.3 2 0 0 2 2 2 2 Glutamate synthase central domain GXGXG PF01493.19 CAV17481.1 - 1.2e-83 279.4 1.8 2.2e-83 278.5 1.8 1.4 1 0 0 1 1 1 1 GXGXG motif Npa1 PF11707.8 CAV17481.1 - 0.075 12.4 0.1 0.14 11.5 0.1 1.3 1 0 0 1 1 1 0 Ribosome 60S biogenesis N-terminal AWS PF17907.1 CAV17481.1 - 0.2 11.7 0.4 0.39 10.8 0.4 1.5 1 0 0 1 1 1 0 AWS domain Radical_SAM_C PF16199.5 CAV17482.1 - 6.5e-19 67.7 0.0 1.4e-18 66.6 0.0 1.6 1 0 0 1 1 1 1 Radical_SAM C-terminal domain Radical_SAM PF04055.21 CAV17482.1 - 9e-18 65.2 0.1 1.4e-17 64.6 0.1 1.4 1 0 0 1 1 1 1 Radical SAM superfamily zf-4CXXC_R1 PF10497.9 CAV17482.1 - 0.076 13.3 0.0 0.16 12.2 0.0 1.6 1 0 0 1 1 1 0 Zinc-finger domain of monoamine-oxidase A repressor R1 FTCD PF02971.14 CAV17482.1 - 0.1 12.6 0.0 1 9.4 0.0 2.4 3 0 0 3 3 3 0 Formiminotransferase domain Botulinum_HA-17 PF05588.11 CAV17482.1 - 0.13 12.4 0.0 0.22 11.6 0.0 1.3 1 0 0 1 1 1 0 Clostridium botulinum HA-17 domain GGDEF PF00990.21 CAV17483.1 - 5.1e-50 169.4 0.0 8.9e-50 168.6 0.0 1.4 1 0 0 1 1 1 1 Diguanylate cyclase, GGDEF domain PAS_4 PF08448.10 CAV17483.1 - 3.5e-23 81.9 0.0 2.4e-15 56.7 0.0 4.4 4 0 0 4 4 4 3 PAS fold PAS PF00989.25 CAV17483.1 - 5.2e-16 58.7 0.0 4.3e-08 33.1 0.0 4.2 3 1 1 4 4 4 3 PAS fold PAS_8 PF13188.7 CAV17483.1 - 1.2e-10 41.2 0.0 0.0029 17.6 0.0 4.6 4 0 0 4 4 4 3 PAS domain PAS_9 PF13426.7 CAV17483.1 - 1.2e-10 41.6 0.0 2.5e-05 24.4 0.0 4.2 4 1 0 5 5 5 2 PAS domain PAS_10 PF13596.6 CAV17483.1 - 0.00029 21.4 0.0 0.0094 16.5 0.0 3.0 3 0 0 3 3 3 1 PAS domain PAS_7 PF12860.7 CAV17483.1 - 0.026 14.7 0.0 7.3 6.8 0.0 3.7 3 1 0 3 3 3 0 PAS fold MLTR_LBD PF17765.1 CAV17483.1 - 0.06 13.5 0.0 14 5.8 0.0 3.2 4 0 0 4 4 4 0 MmyB-like transcription regulator ligand binding domain HKR_ArcB_TM PF18415.1 CAV17484.1 - 2.1e-29 102.1 3.4 4.1e-29 101.2 3.4 1.5 1 0 0 1 1 1 1 Histidine kinase receptor ArcB trans-membrane domain HATPase_c PF02518.26 CAV17484.1 - 7.5e-27 94.1 1.1 1.5e-26 93.1 0.5 1.9 2 0 0 2 2 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase PAS_4 PF08448.10 CAV17484.1 - 2.2e-18 66.5 0.2 1.6e-17 63.8 0.0 2.2 2 0 0 2 2 2 1 PAS fold Response_reg PF00072.24 CAV17484.1 - 4.5e-18 65.4 1.2 2.9e-17 62.8 0.1 2.5 2 0 0 2 2 2 1 Response regulator receiver domain PAS PF00989.25 CAV17484.1 - 4.5e-17 62.1 0.0 1.1e-16 60.8 0.0 1.7 1 0 0 1 1 1 1 PAS fold Hpt PF01627.23 CAV17484.1 - 1.1e-13 51.2 1.6 5e-12 45.9 0.0 3.3 2 1 1 3 3 3 1 Hpt domain HisKA PF00512.25 CAV17484.1 - 1.1e-13 51.0 2.0 3.1e-13 49.6 0.1 2.6 2 1 0 2 2 2 1 His Kinase A (phospho-acceptor) domain PAS_9 PF13426.7 CAV17484.1 - 4.1e-10 39.9 0.0 1.3e-09 38.2 0.0 1.9 1 0 0 1 1 1 1 PAS domain HAUS-augmin3 PF14932.6 CAV17484.1 - 0.0014 18.3 3.6 0.0028 17.3 3.6 1.4 1 0 0 1 1 1 1 HAUS augmin-like complex subunit 3 HATPase_c_3 PF13589.6 CAV17484.1 - 0.0027 17.5 0.1 0.0071 16.2 0.1 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase PAS_8 PF13188.7 CAV17484.1 - 0.0029 17.6 0.0 0.0085 16.1 0.0 1.9 1 0 0 1 1 1 1 PAS domain ADIP PF11559.8 CAV17484.1 - 0.011 15.8 1.8 0.011 15.8 1.8 1.8 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding COG2 PF06148.11 CAV17484.1 - 0.051 13.7 2.0 0.23 11.6 2.0 2.1 1 0 0 1 1 1 0 COG (conserved oligomeric Golgi) complex component, COG2 Na_H_Exchanger PF00999.21 CAV17484.1 - 0.067 12.0 2.6 0.1 11.4 2.6 1.1 1 0 0 1 1 1 0 Sodium/hydrogen exchanger family YabA PF06156.13 CAV17484.1 - 6.7 7.4 7.8 14 6.4 5.6 2.7 3 0 0 3 3 3 0 Initiation control protein YabA LPAM_1 PF08139.12 CAV17485.1 - 1.9 9.1 4.3 6.6 7.4 4.3 2.0 1 1 0 1 1 1 0 Prokaryotic membrane lipoprotein lipid attachment site Response_reg PF00072.24 CAV17486.1 - 1.6e-27 95.9 0.3 3.1e-27 95.0 0.1 1.6 2 0 0 2 2 2 1 Response regulator receiver domain Trans_reg_C PF00486.28 CAV17486.1 - 2.3e-17 62.8 0.0 4.9e-17 61.8 0.0 1.6 1 0 0 1 1 1 1 Transcriptional regulatory protein, C terminal RraA-like PF03737.15 CAV17487.1 - 4.8e-44 150.2 0.2 5.3e-44 150.0 0.2 1.0 1 0 0 1 1 1 1 Aldolase/RraA DUF481 PF04338.12 CAV17488.1 - 0.0022 18.1 1.9 0.0035 17.4 1.9 1.4 1 1 0 1 1 1 1 Protein of unknown function, DUF481 Opacity PF02462.15 CAV17488.1 - 0.031 14.4 0.5 0.084 13.0 0.5 2.0 1 1 0 1 1 1 0 Opacity family porin protein AA_kinase PF00696.28 CAV17489.1 - 4.2e-53 180.4 0.3 3.8e-52 177.3 0.0 2.1 2 0 0 2 2 2 1 Amino acid kinase family Homoserine_dh PF00742.19 CAV17489.1 - 1.2e-46 158.7 0.0 3.5e-46 157.3 0.0 1.8 2 0 0 2 2 2 1 Homoserine dehydrogenase NAD_binding_3 PF03447.16 CAV17489.1 - 3.4e-27 95.4 0.1 1.6e-26 93.3 0.0 2.2 2 0 0 2 2 2 1 Homoserine dehydrogenase, NAD binding domain ACT PF01842.25 CAV17489.1 - 1.8e-16 59.6 0.2 3.7e-09 36.2 0.0 2.7 2 0 0 2 2 2 2 ACT domain ACT_7 PF13840.6 CAV17489.1 - 3.2e-16 58.9 2.9 1.6e-07 31.0 0.2 2.6 2 0 0 2 2 2 2 ACT domain GHMP_kinases_N PF00288.26 CAV17490.1 - 1.4e-13 50.8 0.1 3.2e-13 49.7 0.1 1.6 1 0 0 1 1 1 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.13 CAV17490.1 - 9.6e-11 41.9 0.4 8.1e-10 38.9 0.0 2.3 2 0 0 2 2 2 1 GHMP kinases C terminal LAGLIDADG_3 PF14528.6 CAV17490.1 - 0.13 12.6 0.0 0.26 11.6 0.0 1.4 1 0 0 1 1 1 0 LAGLIDADG-like domain PALP PF00291.25 CAV17491.1 - 2.3e-23 83.1 0.0 3.3e-23 82.5 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Thr_synth_N PF14821.6 CAV17491.1 - 3.5e-09 36.7 0.0 1.4e-08 34.8 0.0 2.0 2 0 0 2 2 2 1 Threonine synthase N terminus rve_3 PF13683.6 CAV17492.1 - 1.2e-05 25.0 0.0 1.4e-05 24.7 0.0 1.2 1 0 0 1 1 1 1 Integrase core domain rve_2 PF13333.6 CAV17492.1 - 0.036 14.3 0.0 0.04 14.1 0.0 1.1 1 0 0 1 1 1 0 Integrase core domain rve PF00665.26 CAV17493.1 - 1.8e-07 31.3 0.0 1.9e-07 31.3 0.0 1.0 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 CAV17493.1 - 0.08 12.7 0.0 0.12 12.1 0.0 1.3 1 0 0 1 1 1 0 Integrase core domain ANT PF03374.14 CAV17495.1 - 0.017 15.4 0.0 0.024 14.9 0.0 1.3 1 0 0 1 1 1 0 Phage antirepressor protein KilAC domain Acyl_transf_3 PF01757.22 CAV17498.1 - 1.5e-23 83.5 41.2 1.5e-23 83.5 41.2 2.1 1 1 1 2 2 2 1 Acyltransferase family U62_UL91 PF17442.2 CAV17498.1 - 0.076 13.0 0.1 0.16 12.0 0.1 1.5 1 0 0 1 1 1 0 Functional domain of U62 and UL91 proteins Insulin_TMD PF17870.1 CAV17498.1 - 0.97 9.6 4.2 0.87 9.7 0.7 3.0 2 0 0 2 2 2 0 Insulin receptor trans-membrane segment DDE_Tnp_1 PF01609.21 CAV17499.1 - 0.013 15.1 0.0 0.013 15.1 0.0 1.0 1 0 0 1 1 1 0 Transposase DDE domain Importin_rep PF18773.1 CAV17500.1 - 0.016 14.9 0.1 0.023 14.4 0.1 1.2 1 0 0 1 1 1 0 Importin 13 repeat Cut12 PF11500.8 CAV17500.1 - 0.15 12.0 0.9 0.17 11.8 0.9 1.1 1 0 0 1 1 1 0 Spindle pole body formation-associated protein Sugarporin_N PF11471.8 CAV17502.1 - 0.0043 17.0 2.1 0.0076 16.2 2.1 1.4 1 0 0 1 1 1 1 Maltoporin periplasmic N-terminal extension HTH_Tnp_1 PF01527.20 CAV17502.1 - 0.081 13.3 3.1 0.3 11.4 3.1 1.9 1 1 0 1 1 1 0 Transposase rve PF00665.26 CAV17503.1 - 1.8e-26 92.6 0.1 6.2e-26 90.9 0.0 1.8 2 0 0 2 2 2 1 Integrase core domain rve_3 PF13683.6 CAV17503.1 - 2.6e-19 68.8 0.0 5.3e-19 67.8 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain DDE_Tnp_IS240 PF13610.6 CAV17503.1 - 0.0001 22.5 0.2 0.00018 21.7 0.2 1.4 1 0 0 1 1 1 1 DDE domain HTH_21 PF13276.6 CAV17503.1 - 0.015 15.4 1.6 0.043 14.0 1.0 2.1 2 0 0 2 2 2 0 HTH-like domain rve_2 PF13333.6 CAV17503.1 - 0.051 13.7 0.1 0.1 12.8 0.1 1.5 1 0 0 1 1 1 0 Integrase core domain RlmM_FDX PF18125.1 CAV17503.1 - 0.13 12.8 0.0 0.47 11.0 0.0 1.9 1 0 0 1 1 1 0 RlmM ferredoxin-like domain Gly_radical PF01228.21 CAV17504.1 - 8.7e-23 80.9 0.0 1.1e-22 80.5 0.0 1.2 1 0 0 1 1 1 1 Glycine radical AP_endonuc_2 PF01261.24 CAV17505.1 - 4.5e-42 143.9 0.3 9.3e-42 142.8 0.2 1.5 2 0 0 2 2 2 1 Xylose isomerase-like TIM barrel UDG PF03167.19 CAV17506.1 - 5.3e-26 91.5 0.0 7.4e-26 91.0 0.0 1.1 1 0 0 1 1 1 1 Uracil DNA glycosylase superfamily Hemerythrin PF01814.23 CAV17507.1 - 2.7e-13 50.7 5.9 4.3e-13 50.0 5.9 1.3 1 0 0 1 1 1 1 Hemerythrin HHE cation binding domain Thymosin PF01290.20 CAV17507.1 - 0.13 12.0 0.0 0.36 10.6 0.0 1.7 1 0 0 1 1 1 0 Thymosin beta-4 family DUF3545 PF12065.8 CAV17508.1 - 1.3e-24 86.0 4.6 1.4e-24 85.8 4.6 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3545) Na_Ala_symp PF01235.17 CAV17509.1 - 2.8e-161 537.2 32.3 3.5e-161 536.9 32.3 1.0 1 0 0 1 1 1 1 Sodium:alanine symporter family DUF2478 PF10649.9 CAV17509.1 - 0.086 12.4 0.1 0.15 11.6 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2478) H2O2_YaaD PF03883.14 CAV17510.1 - 3.4e-94 314.7 0.1 3.9e-94 314.5 0.1 1.0 1 0 0 1 1 1 1 Peroxide stress protein YaaA DEAD PF00270.29 CAV17511.1 - 1.3e-45 155.3 0.0 2.6e-45 154.4 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CAV17511.1 - 1.8e-33 115.2 0.9 1.8e-31 108.8 0.1 2.8 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 CAV17511.1 - 1.3e-07 31.8 0.1 6.9e-07 29.4 0.0 2.0 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_19 PF13245.6 CAV17511.1 - 4.8e-05 23.7 0.0 9.7e-05 22.7 0.0 1.5 1 0 0 1 1 1 1 AAA domain MTS PF05175.14 CAV17512.1 - 1.6e-15 57.1 0.0 2.3e-15 56.5 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain PrmA PF06325.13 CAV17512.1 - 8.9e-12 45.0 0.0 1.3e-11 44.4 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_25 PF13649.6 CAV17512.1 - 2e-11 44.4 0.0 4.1e-11 43.4 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CAV17512.1 - 5.9e-10 39.1 0.1 1.2e-09 38.2 0.1 1.4 1 1 0 1 1 1 1 Methyltransferase domain UPF0020 PF01170.18 CAV17512.1 - 1e-07 31.9 0.0 1.5e-07 31.3 0.0 1.3 1 0 0 1 1 1 1 Putative RNA methylase family UPF0020 Methyltransf_10 PF05971.12 CAV17512.1 - 1.6e-07 30.9 0.0 2.2e-07 30.5 0.0 1.1 1 0 0 1 1 1 1 RNA methyltransferase Methyltransf_3 PF01596.17 CAV17512.1 - 1.1e-06 28.0 0.0 1.9e-06 27.2 0.0 1.3 1 0 0 1 1 1 1 O-methyltransferase Methyltransf_12 PF08242.12 CAV17512.1 - 5.3e-06 27.1 0.0 8.5e-06 26.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.7 CAV17512.1 - 8.9e-06 25.7 0.0 1.6e-05 24.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CAV17512.1 - 1.5e-05 25.5 0.0 2.9e-05 24.6 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CAV17512.1 - 0.00034 20.5 0.0 0.00047 20.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 CAV17512.1 - 0.00046 20.0 0.0 0.00069 19.4 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) CMAS PF02353.20 CAV17512.1 - 0.0029 16.9 0.0 0.0046 16.3 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Cons_hypoth95 PF03602.15 CAV17512.1 - 0.0035 17.0 0.0 0.0051 16.5 0.0 1.2 1 0 0 1 1 1 1 Conserved hypothetical protein 95 Methyltransf_4 PF02390.17 CAV17512.1 - 0.0037 16.7 0.0 0.0053 16.2 0.0 1.2 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_16 PF10294.9 CAV17512.1 - 0.0049 16.6 0.0 0.0081 15.9 0.0 1.3 1 0 0 1 1 1 1 Lysine methyltransferase Met_10 PF02475.16 CAV17512.1 - 0.01 15.6 0.0 0.015 15.0 0.0 1.2 1 0 0 1 1 1 0 Met-10+ like-protein N6_Mtase PF02384.16 CAV17512.1 - 0.017 14.4 0.0 0.022 14.0 0.0 1.2 1 0 0 1 1 1 0 N-6 DNA Methylase Eco57I PF07669.11 CAV17512.1 - 0.024 15.1 0.0 0.044 14.3 0.0 1.4 1 0 0 1 1 1 0 Eco57I restriction-modification methylase rRNA_methylase PF06962.12 CAV17512.1 - 0.028 14.4 0.0 0.045 13.7 0.0 1.4 1 0 0 1 1 1 0 Putative rRNA methylase Methyltransf_32 PF13679.6 CAV17512.1 - 0.1 12.6 0.0 0.16 12.0 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Methyltr_RsmB-F PF01189.17 CAV17512.1 - 0.14 11.7 0.0 0.2 11.3 0.0 1.2 1 0 0 1 1 1 0 16S rRNA methyltransferase RsmB/F DOT1 PF08123.13 CAV17512.1 - 0.19 11.2 0.0 0.26 10.8 0.0 1.2 1 0 0 1 1 1 0 Histone methylation protein DOT1 Branch_AA_trans PF05525.13 CAV17513.1 - 2.1e-152 507.9 39.9 2.5e-152 507.7 39.9 1.0 1 0 0 1 1 1 1 Branched-chain amino acid transport protein DUF5389 PF17364.2 CAV17513.1 - 0.051 13.6 0.4 0.051 13.6 0.4 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF5389) HTH_28 PF13518.6 CAV17514.1 - 0.00018 21.6 0.1 0.0004 20.5 0.1 1.6 1 0 0 1 1 1 1 Helix-turn-helix domain Sugarporin_N PF11471.8 CAV17514.1 - 0.0027 17.6 1.8 0.0044 16.9 1.8 1.3 1 0 0 1 1 1 1 Maltoporin periplasmic N-terminal extension HTH_21 PF13276.6 CAV17515.1 - 0.0043 17.1 1.3 0.0063 16.6 1.3 1.2 1 0 0 1 1 1 1 HTH-like domain Flavodoxin_1 PF00258.25 CAV17516.1 - 1.1e-26 93.7 0.3 1.3e-26 93.6 0.3 1.0 1 0 0 1 1 1 1 Flavodoxin Flavodoxin_3 PF12641.7 CAV17516.1 - 0.0012 18.6 0.0 0.0044 16.7 0.0 1.7 1 1 1 2 2 2 1 Flavodoxin domain Phage_integrase PF00589.22 CAV17517.1 - 4.2e-53 179.7 0.0 6.6e-53 179.0 0.0 1.3 1 0 0 1 1 1 1 Phage integrase family Phage_int_SAM_1 PF02899.17 CAV17517.1 - 6.5e-20 71.2 3.9 2.9e-19 69.2 1.2 2.5 2 1 0 2 2 2 1 Phage integrase, N-terminal SAM-like domain Phage_int_SAM_4 PF13495.6 CAV17517.1 - 1.7e-06 28.4 1.1 6.3e-06 26.6 0.3 2.2 2 0 0 2 2 2 1 Phage integrase, N-terminal SAM-like domain Phage_int_SAM_5 PF13102.6 CAV17517.1 - 0.0011 19.3 0.0 0.0025 18.1 0.0 1.6 1 0 0 1 1 1 1 Phage integrase SAM-like domain Thioredoxin_2 PF13098.6 CAV17518.1 - 1.2e-24 86.9 0.0 1.8e-24 86.2 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin-like domain DsbC_N PF10411.9 CAV17518.1 - 4.5e-14 51.6 0.0 7.7e-14 50.9 0.0 1.4 1 0 0 1 1 1 1 Disulfide bond isomerase protein N-terminus DSBA PF01323.20 CAV17518.1 - 4e-06 26.7 0.2 0.008 16.0 0.0 2.6 2 1 1 3 3 3 2 DSBA-like thioredoxin domain Thioredoxin_4 PF13462.6 CAV17518.1 - 0.00014 22.1 0.1 0.26 11.4 0.0 2.5 1 1 0 2 2 2 2 Thioredoxin DHHA1 PF02272.19 CAV17519.1 - 3.3e-26 92.3 0.0 9.7e-26 90.8 0.0 1.8 2 0 0 2 2 2 1 DHHA1 domain RecJ_OB PF17768.1 CAV17519.1 - 1.8e-18 66.7 0.0 3.4e-18 65.9 0.0 1.5 1 0 0 1 1 1 1 RecJ OB domain DHH PF01368.20 CAV17519.1 - 8e-09 35.7 0.0 1.5e-08 34.8 0.0 1.5 1 0 0 1 1 1 1 DHH family PCRF PF03462.18 CAV17521.1 - 1.1e-49 169.0 2.3 1.8e-49 168.2 0.1 2.0 2 0 0 2 2 2 1 PCRF domain RF-1 PF00472.20 CAV17521.1 - 8.9e-41 138.5 2.4 1.5e-40 137.8 2.4 1.3 1 0 0 1 1 1 1 RF-1 domain MIR PF02815.19 CAV17521.1 - 0.0034 17.2 0.3 0.012 15.4 0.1 1.9 1 1 1 2 2 2 1 MIR domain DUF4140 PF13600.6 CAV17521.1 - 0.011 16.1 5.1 0.11 13.0 0.7 2.5 2 0 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) MCU PF04678.13 CAV17521.1 - 0.025 14.7 1.0 0.68 10.0 0.1 2.2 2 0 0 2 2 2 0 Mitochondrial calcium uniporter End3 PF12761.7 CAV17521.1 - 0.031 14.5 3.5 0.6 10.2 0.2 2.2 2 0 0 2 2 2 0 Actin cytoskeleton-regulatory complex protein END3 Osmo_CC PF08946.10 CAV17521.1 - 0.054 13.8 1.5 0.54 10.5 0.1 2.6 2 0 0 2 2 2 0 Osmosensory transporter coiled coil DUF2408 PF10303.9 CAV17521.1 - 0.075 13.6 1.2 6.7 7.3 0.7 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2408) YusW PF14039.6 CAV17521.1 - 0.21 12.1 3.4 0.58 10.7 0.3 2.5 2 0 0 2 2 2 0 YusW-like protein tRNA-synt_2 PF00152.20 CAV17522.1 - 2.7e-77 260.0 0.2 3.4e-77 259.6 0.2 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 CAV17522.1 - 8.3e-07 28.9 0.0 1.5e-06 28.1 0.0 1.4 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.20 CAV17522.1 - 0.00043 19.8 0.1 0.51 9.8 0.0 2.5 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) Methyltransf_23 PF13489.6 CAV17522.1 - 0.092 12.6 0.3 0.77 9.6 0.0 2.5 3 0 0 3 3 3 0 Methyltransferase domain Sigma54_activat PF00158.26 CAV17523.1 - 3.7e-39 134.1 0.0 5.9e-39 133.5 0.0 1.3 1 0 0 1 1 1 1 Sigma-54 interaction domain Sigma54_activ_2 PF14532.6 CAV17523.1 - 1.6e-22 80.1 0.0 4.4e-22 78.7 0.0 1.8 1 0 0 1 1 1 1 Sigma-54 interaction domain HTH_8 PF02954.19 CAV17523.1 - 1.1e-08 34.7 1.0 5.3e-08 32.5 0.3 2.4 3 0 0 3 3 3 1 Bacterial regulatory protein, Fis family AAA_16 PF13191.6 CAV17523.1 - 0.00031 21.2 0.0 0.0013 19.2 0.0 1.9 2 0 0 2 2 2 1 AAA ATPase domain AAA PF00004.29 CAV17523.1 - 0.0013 19.2 0.1 0.0033 17.9 0.0 1.8 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) HTH_7 PF02796.15 CAV17523.1 - 0.0024 17.9 0.0 0.013 15.6 0.0 2.2 2 0 0 2 2 2 1 Helix-turn-helix domain of resolvase HTH_22 PF13309.6 CAV17523.1 - 0.0042 17.1 0.1 0.02 15.0 0.0 2.1 2 0 0 2 2 2 1 HTH domain AAA_5 PF07728.14 CAV17523.1 - 0.0044 17.0 0.0 0.011 15.7 0.0 1.6 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) HTH_30 PF13556.6 CAV17523.1 - 0.0071 16.1 0.0 0.49 10.2 0.0 2.4 2 0 0 2 2 2 1 PucR C-terminal helix-turn-helix domain AAA_22 PF13401.6 CAV17523.1 - 0.0072 16.6 0.1 0.19 12.0 0.0 2.4 2 0 0 2 2 2 1 AAA domain HTH_17 PF12728.7 CAV17523.1 - 0.0081 16.3 0.0 0.02 15.1 0.0 1.6 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_50 PF18024.1 CAV17523.1 - 0.01 15.4 0.5 0.01 15.4 0.5 2.2 3 0 0 3 3 2 0 Helix-turn-helix domain AAA_2 PF07724.14 CAV17523.1 - 0.011 15.9 0.0 0.026 14.7 0.0 1.4 1 1 0 1 1 1 0 AAA domain (Cdc48 subfamily) NB-ARC PF00931.22 CAV17523.1 - 0.027 13.7 0.1 0.065 12.4 0.0 1.6 2 0 0 2 2 2 0 NB-ARC domain HTH_29 PF13551.6 CAV17523.1 - 0.037 14.0 0.0 0.092 12.8 0.0 1.6 1 0 0 1 1 1 0 Winged helix-turn helix ATPase PF06745.13 CAV17523.1 - 0.041 13.2 0.0 1.2 8.4 0.0 2.2 2 0 0 2 2 2 0 KaiC MCM PF00493.23 CAV17523.1 - 0.041 13.0 0.0 0.077 12.1 0.0 1.4 1 0 0 1 1 1 0 MCM P-loop domain IstB_IS21 PF01695.17 CAV17523.1 - 0.084 12.6 0.0 5 6.8 0.0 2.3 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA_24 PF13479.6 CAV17523.1 - 0.12 12.0 0.0 0.2 11.4 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 CAV17523.1 - 0.14 11.7 0.0 0.24 10.9 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region HTH_23 PF13384.6 CAV17523.1 - 0.15 11.9 0.0 0.36 10.7 0.0 1.6 1 0 0 1 1 1 0 Homeodomain-like domain MutH PF02976.15 CAV17527.1 - 1.4e-33 115.0 0.0 2.2e-33 114.3 0.0 1.3 1 0 0 1 1 1 1 DNA mismatch repair enzyme MutH DUF3269 PF11673.8 CAV17527.1 - 0.097 13.1 0.0 0.16 12.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3269) NUDIX PF00293.28 CAV17528.1 - 5e-27 94.5 0.1 6.4e-27 94.2 0.1 1.1 1 0 0 1 1 1 1 NUDIX domain NUDIX_4 PF14815.6 CAV17528.1 - 0.057 13.4 0.1 0.092 12.7 0.1 1.5 1 1 0 1 1 1 0 NUDIX domain PEP-utilizers_C PF02896.18 CAV17529.1 - 1.9e-94 316.1 0.0 3e-94 315.5 0.0 1.2 1 0 0 1 1 1 1 PEP-utilising enzyme, TIM barrel domain PEP-utilisers_N PF05524.13 CAV17529.1 - 1e-23 83.7 0.1 3.2e-23 82.1 0.0 1.9 2 0 0 2 2 2 1 PEP-utilising enzyme, N-terminal PEP-utilizers PF00391.23 CAV17529.1 - 7.6e-16 57.6 0.1 2.1e-15 56.2 0.1 1.8 1 0 0 1 1 1 1 PEP-utilising enzyme, mobile domain GAF PF01590.26 CAV17529.1 - 5.4e-14 53.0 0.0 1.1e-13 51.9 0.0 1.6 1 0 0 1 1 1 1 GAF domain GAF_2 PF13185.6 CAV17529.1 - 3.3e-12 46.9 0.0 6.8e-12 45.9 0.0 1.6 1 0 0 1 1 1 1 GAF domain GAF_3 PF13492.6 CAV17529.1 - 1.3e-07 32.0 0.1 6.2e-07 29.8 0.1 2.1 1 1 0 1 1 1 1 GAF domain HpcH_HpaI PF03328.14 CAV17529.1 - 0.045 12.9 0.0 0.083 12.0 0.0 1.3 1 0 0 1 1 1 0 HpcH/HpaI aldolase/citrate lyase family TauE PF01925.19 CAV17530.1 - 1.5e-50 172.1 35.5 1.8e-50 171.8 35.5 1.0 1 0 0 1 1 1 1 Sulfite exporter TauE/SafE LGT PF01790.18 CAV17531.1 - 1.5e-83 279.7 8.7 1.8e-83 279.5 8.7 1.0 1 0 0 1 1 1 1 Prolipoprotein diacylglyceryl transferase FixS PF03597.15 CAV17531.1 - 0.025 14.3 0.0 0.025 14.3 0.0 3.6 5 0 0 5 5 5 0 Cytochrome oxidase maturation protein cbb3-type DUF202 PF02656.15 CAV17531.1 - 0.075 13.5 5.6 11 6.6 0.1 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF202) DUF4234 PF14018.6 CAV17531.1 - 0.18 11.9 3.3 1.4 9.1 0.9 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF4234) Thymidylat_synt PF00303.19 CAV17532.1 - 3.2e-73 246.1 0.0 3.6e-73 246.0 0.0 1.0 1 0 0 1 1 1 1 Thymidylate synthase Trans_reg_C PF00486.28 CAV17533.1 - 6.6e-16 58.2 0.2 1.4e-15 57.1 0.2 1.5 1 0 0 1 1 1 1 Transcriptional regulatory protein, C terminal HTH_11 PF08279.12 CAV17533.1 - 0.1 12.6 1.1 0.21 11.6 0.2 2.0 2 0 0 2 2 2 0 HTH domain Na_Pi_cotrans PF02690.15 CAV17535.1 - 1.7e-42 144.8 27.9 4.1e-23 82.0 7.9 2.6 2 1 0 2 2 2 2 Na+/Pi-cotransporter Caveolin PF01146.17 CAV17535.1 - 0.082 12.9 0.3 0.082 12.9 0.3 2.4 2 0 0 2 2 2 0 Caveolin YccF PF03733.13 CAV17535.1 - 0.3 11.8 0.3 0.3 11.8 0.3 3.9 4 0 0 4 4 4 0 Inner membrane component domain HTH_1 PF00126.27 CAV17536.1 - 4.6e-16 58.5 0.0 8.6e-16 57.6 0.0 1.5 1 0 0 1 1 1 1 Bacterial regulatory helix-turn-helix protein, lysR family LysR_substrate PF03466.20 CAV17536.1 - 4.8e-10 39.1 0.0 7.4e-10 38.5 0.0 1.2 1 0 0 1 1 1 1 LysR substrate binding domain HTH_30 PF13556.6 CAV17536.1 - 0.0012 18.6 0.0 0.0023 17.7 0.0 1.4 1 0 0 1 1 1 1 PucR C-terminal helix-turn-helix domain HTH_5 PF01022.20 CAV17537.1 - 2.9e-16 59.1 0.5 4.3e-16 58.5 0.5 1.3 1 0 0 1 1 1 1 Bacterial regulatory protein, arsR family HTH_20 PF12840.7 CAV17537.1 - 1.7e-11 44.0 0.8 2.7e-11 43.4 0.8 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain MarR_2 PF12802.7 CAV17537.1 - 2e-06 27.6 0.3 2.5e-06 27.3 0.3 1.2 1 0 0 1 1 1 1 MarR family HTH_24 PF13412.6 CAV17537.1 - 3.4e-05 23.3 0.2 8.3e-05 22.1 0.2 1.7 1 1 0 1 1 1 1 Winged helix-turn-helix DNA-binding HTH_27 PF13463.6 CAV17537.1 - 0.0017 18.8 0.1 0.0027 18.1 0.1 1.5 1 1 0 1 1 1 1 Winged helix DNA-binding domain HTH_11 PF08279.12 CAV17537.1 - 0.002 18.0 0.1 0.003 17.5 0.1 1.3 1 0 0 1 1 1 1 HTH domain Rrf2 PF02082.20 CAV17537.1 - 0.0038 17.5 0.1 0.0064 16.8 0.1 1.6 1 1 0 1 1 1 1 Transcriptional regulator TrmB PF01978.19 CAV17537.1 - 0.0044 16.9 0.0 0.0089 15.9 0.0 1.5 1 1 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB HTH_34 PF13601.6 CAV17537.1 - 0.0074 16.4 0.0 0.012 15.8 0.0 1.3 1 0 0 1 1 1 1 Winged helix DNA-binding domain TFIIE_alpha PF02002.17 CAV17537.1 - 0.012 15.5 0.0 0.018 14.9 0.0 1.3 1 0 0 1 1 1 0 TFIIE alpha subunit GntR PF00392.21 CAV17537.1 - 0.012 15.2 0.2 0.018 14.7 0.2 1.3 1 0 0 1 1 1 0 Bacterial regulatory proteins, gntR family DUF2582 PF10771.9 CAV17537.1 - 0.012 15.7 0.1 0.024 14.8 0.0 1.5 2 0 0 2 2 2 0 Winged helix-turn-helix domain (DUF2582) FeoC PF09012.10 CAV17537.1 - 0.015 15.3 0.4 0.14 12.2 0.1 2.1 1 1 1 2 2 2 0 FeoC like transcriptional regulator MarR PF01047.22 CAV17537.1 - 0.019 14.9 0.1 0.035 14.0 0.1 1.5 1 0 0 1 1 1 0 MarR family HTH_IclR PF09339.10 CAV17537.1 - 0.024 14.4 0.9 0.036 13.9 0.9 1.4 1 0 0 1 1 1 0 IclR helix-turn-helix domain HxlR PF01638.17 CAV17537.1 - 0.032 14.1 0.1 0.05 13.5 0.1 1.4 1 1 0 1 1 1 0 HxlR-like helix-turn-helix PadR PF03551.14 CAV17537.1 - 0.054 13.5 0.0 0.084 12.8 0.0 1.4 1 0 0 1 1 1 0 Transcriptional regulator PadR-like family HTH_1 PF00126.27 CAV17537.1 - 0.064 13.2 0.0 0.11 12.4 0.0 1.5 1 0 0 1 1 1 0 Bacterial regulatory helix-turn-helix protein, lysR family HTH_Crp_2 PF13545.6 CAV17537.1 - 0.072 13.1 0.1 0.092 12.7 0.1 1.3 1 0 0 1 1 1 0 Crp-like helix-turn-helix domain PaaX PF07848.12 CAV17537.1 - 0.094 13.0 0.0 0.14 12.4 0.0 1.3 1 0 0 1 1 1 0 PaaX-like protein HTH_28 PF13518.6 CAV17537.1 - 0.11 12.7 0.1 0.18 12.0 0.1 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain LexA_DNA_bind PF01726.16 CAV17537.1 - 0.13 12.0 0.0 0.28 11.0 0.0 1.5 1 0 0 1 1 1 0 LexA DNA binding domain HTH_53 PF18606.1 CAV17537.1 - 0.21 11.3 3.1 0.22 11.2 2.2 1.6 1 1 1 2 2 2 0 Zap helix turn helix N-terminal domain Ribosomal_S20p PF01649.18 CAV17538.1 - 2.3e-27 95.5 14.7 2.5e-27 95.3 14.7 1.0 1 0 0 1 1 1 1 Ribosomal protein S20 DUF4798 PF16055.5 CAV17538.1 - 0.0026 18.0 3.3 0.01 16.0 0.0 2.0 1 1 1 2 2 2 1 Domain of unknown function (DUF4798) MurJ PF03023.14 CAV17539.1 - 1.1e-145 485.8 29.4 1.3e-145 485.5 29.4 1.1 1 0 0 1 1 1 1 Lipid II flippase MurJ Polysacc_synt_C PF14667.6 CAV17539.1 - 1.1e-13 51.4 19.2 1.1e-13 51.4 19.2 4.2 5 1 1 6 6 6 1 Polysaccharide biosynthesis C-terminal domain FAD_syn PF06574.12 CAV17540.1 - 2.7e-58 196.3 0.0 5.1e-58 195.4 0.0 1.4 1 0 0 1 1 1 1 FAD synthetase Flavokinase PF01687.17 CAV17540.1 - 4.3e-38 130.0 0.0 7.4e-38 129.3 0.0 1.4 1 0 0 1 1 1 1 Riboflavin kinase CTP_transf_like PF01467.26 CAV17540.1 - 2.2e-05 24.7 0.0 3.8e-05 23.9 0.0 1.4 1 0 0 1 1 1 1 Cytidylyltransferase-like tRNA-synt_1 PF00133.22 CAV17541.1 - 7.8e-216 718.0 0.2 9.5e-216 717.7 0.2 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 CAV17541.1 - 5.9e-27 94.5 0.0 1.1e-26 93.6 0.0 1.5 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.11 CAV17541.1 - 7.3e-23 80.9 0.1 7.3e-11 41.4 0.0 3.5 2 1 0 3 3 3 3 tRNA synthetases class I (M) tRNA-synt_1e PF01406.19 CAV17541.1 - 1.1e-08 34.8 0.0 8.5e-07 28.6 0.0 2.3 2 0 0 2 2 2 1 tRNA synthetases class I (C) catalytic domain tRNA-synt_1_2 PF13603.6 CAV17541.1 - 7.7e-07 28.8 0.0 2.3e-06 27.3 0.0 1.7 2 0 0 2 2 2 1 Leucyl-tRNA synthetase, Domain 2 zf-FPG_IleRS PF06827.14 CAV17541.1 - 1.9e-06 27.6 3.6 1.9e-06 27.6 3.6 2.6 2 0 0 2 2 2 1 Zinc finger found in FPG and IleRS tRNA-synt_1f PF01921.18 CAV17541.1 - 2.5e-06 26.6 0.0 1.9e-05 23.8 0.0 2.0 2 0 0 2 2 2 1 tRNA synthetases class I (K) Peptidase_A8 PF01252.18 CAV17542.1 - 3.9e-38 130.9 8.4 4.4e-38 130.7 8.4 1.0 1 0 0 1 1 1 1 Signal peptidase (SPase) II FKBP_C PF00254.28 CAV17543.1 - 2.8e-12 46.8 0.1 1.5e-11 44.4 0.1 1.9 1 1 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase LYTB PF02401.18 CAV17544.1 - 2.6e-92 308.8 0.0 3e-92 308.6 0.0 1.0 1 0 0 1 1 1 1 LytB protein DHDPS PF00701.22 CAV17544.1 - 0.078 11.7 0.0 0.16 10.7 0.0 1.4 1 0 0 1 1 1 0 Dihydrodipicolinate synthetase family ILEI PF15711.5 CAV17544.1 - 0.17 12.4 0.0 19 5.8 0.0 3.0 3 0 0 3 3 3 0 Interleukin-like EMT inducer Response_reg PF00072.24 CAV17545.1 - 4.6e-20 71.9 0.1 1e-19 70.8 0.1 1.6 2 0 0 2 2 2 1 Response regulator receiver domain LytTR PF04397.15 CAV17545.1 - 1.2e-19 70.3 0.2 2.3e-19 69.4 0.2 1.5 1 0 0 1 1 1 1 LytTr DNA-binding domain DUF3213 PF11491.8 CAV17545.1 - 0.17 12.1 2.7 0.82 9.9 0.5 2.6 1 1 2 3 3 3 0 Protein of unknown function (DUF3213) 5TM-5TMR_LYT PF07694.12 CAV17546.1 - 1.3e-60 203.8 11.8 2e-60 203.1 11.8 1.3 1 0 0 1 1 1 1 5TMR of 5TMR-LYT His_kinase PF06580.13 CAV17546.1 - 4.8e-26 90.9 1.1 8.9e-26 90.0 1.1 1.5 1 0 0 1 1 1 1 Histidine kinase SpoVT_C PF15714.5 CAV17546.1 - 9.6e-07 28.9 0.1 2.8e-06 27.4 0.0 1.9 2 0 0 2 2 2 1 Stage V sporulation protein T C-terminal, transcription factor GAF_2 PF13185.6 CAV17546.1 - 1.1e-05 25.7 0.0 2.3e-05 24.7 0.0 1.6 1 0 0 1 1 1 1 GAF domain GAF_3 PF13492.6 CAV17546.1 - 3.4e-05 24.2 0.0 9.2e-05 22.8 0.0 1.7 1 1 0 1 1 1 1 GAF domain HATPase_c PF02518.26 CAV17546.1 - 0.016 15.7 0.0 0.24 11.9 0.0 2.5 1 1 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase GAF PF01590.26 CAV17546.1 - 0.052 14.2 0.0 0.12 13.0 0.0 1.7 1 0 0 1 1 1 0 GAF domain ECF_trnsprt PF12822.7 CAV17546.1 - 0.12 12.5 13.7 0.23 11.5 13.7 1.5 1 0 0 1 1 1 0 ECF transporter, substrate-specific component CstA PF02554.14 CAV17547.1 - 9.1e-52 176.2 26.1 2.3e-33 115.6 6.2 2.7 2 1 1 3 3 3 2 Carbon starvation protein CstA CstA_5TM PF13722.6 CAV17547.1 - 8.6e-21 74.5 6.0 8.6e-21 74.5 6.0 3.0 3 1 0 3 3 3 1 5TM C-terminal transporter carbon starvation CstA Trp_Tyr_perm PF03222.13 CAV17547.1 - 8.4e-06 25.1 11.3 1.7e-05 24.1 11.3 1.5 1 0 0 1 1 1 1 Tryptophan/tyrosine permease family Reticulon PF02453.17 CAV17547.1 - 0.31 11.0 5.8 2 8.4 1.3 2.8 2 0 0 2 2 2 0 Reticulon DUF2799 PF10973.8 CAV17548.1 - 1.1e-22 80.2 4.9 1.5e-22 79.8 4.9 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2799) RMF PF04957.12 CAV17548.1 - 0.019 15.2 2.1 0.96 9.7 0.2 3.0 3 0 0 3 3 3 0 Ribosome modulation factor LPAM_1 PF08139.12 CAV17548.1 - 0.26 11.9 2.8 0.42 11.2 2.8 1.4 1 0 0 1 1 1 0 Prokaryotic membrane lipoprotein lipid attachment site SIS_2 PF13580.6 CAV17549.1 - 5.9e-10 39.3 3.6 2.1e-09 37.5 0.4 2.6 2 1 0 2 2 2 1 SIS domain SIS PF01380.22 CAV17549.1 - 1.3e-09 38.0 1.1 6.9e-09 35.6 0.1 2.2 2 0 0 2 2 2 1 SIS domain AnmK PF03702.14 CAV17550.1 - 3.3e-164 546.3 0.1 3.8e-164 546.1 0.1 1.0 1 0 0 1 1 1 1 Anhydro-N-acetylmuramic acid kinase DUF4287 PF14117.6 CAV17550.1 - 0.083 13.0 0.0 0.82 9.9 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4287) AAA_19 PF13245.6 CAV17550.1 - 0.1 12.9 0.1 0.27 11.6 0.1 1.7 2 0 0 2 2 2 0 AAA domain Glyco_hydro_3 PF00933.21 CAV17551.1 - 1e-85 287.9 0.1 1.3e-85 287.6 0.1 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain DAHP_synth_1 PF00793.20 CAV17552.1 - 8e-105 349.6 0.0 9.7e-105 349.3 0.0 1.0 1 0 0 1 1 1 1 DAHP synthetase I family PDH PF02153.17 CAV17553.1 - 7.8e-29 100.5 0.0 1.1e-28 99.9 0.0 1.2 1 0 0 1 1 1 1 Prephenate dehydrogenase CM_2 PF01817.21 CAV17553.1 - 8.4e-22 77.3 0.9 1.7e-21 76.3 0.9 1.5 1 0 0 1 1 1 1 Chorismate mutase type II Peptidase_M23 PF01551.22 CAV17554.1 - 2.9e-29 101.1 0.0 5e-29 100.4 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M23 Biotin_lipoyl_2 PF13533.6 CAV17554.1 - 0.032 14.1 0.2 0.1 12.4 0.0 1.9 2 0 0 2 2 2 0 Biotin-lipoyl like PilZ PF07238.14 CAV17555.1 - 1.6e-13 50.8 0.3 2e-13 50.5 0.3 1.1 1 0 0 1 1 1 1 PilZ domain PDGF_N PF04692.13 CAV17555.1 - 0.12 13.2 0.8 0.28 12.0 0.8 1.6 1 0 0 1 1 1 0 Platelet-derived growth factor, N terminal region ABC_tran PF00005.27 CAV17556.1 - 3.3e-56 189.6 0.5 9.4e-27 94.2 0.0 3.3 3 0 0 3 3 3 2 ABC transporter AAA_21 PF13304.6 CAV17556.1 - 7.7e-17 62.1 4.0 0.00094 19.1 0.1 4.3 3 1 1 4 4 4 4 AAA domain, putative AbiEii toxin, Type IV TA system ABC_tran_Xtn PF12848.7 CAV17556.1 - 1.9e-14 53.4 10.6 2.6e-12 46.6 4.3 2.4 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 CAV17556.1 - 2.4e-07 30.4 3.9 0.75 9.2 0.8 4.2 3 1 0 3 3 3 3 RecF/RecN/SMC N terminal domain MMR_HSR1 PF01926.23 CAV17556.1 - 5.8e-06 26.4 0.0 0.024 14.7 0.0 2.6 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_29 PF13555.6 CAV17556.1 - 4.1e-05 23.3 2.8 0.059 13.1 0.2 2.4 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_23 PF13476.6 CAV17556.1 - 8.9e-05 23.1 9.0 0.0074 16.8 0.2 3.4 3 2 1 4 4 3 2 AAA domain MeaB PF03308.16 CAV17556.1 - 0.00015 20.8 0.1 0.49 9.3 0.0 2.5 2 0 0 2 2 2 2 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_18 PF13238.6 CAV17556.1 - 0.0003 21.4 0.3 1.1 9.8 0.0 2.9 2 1 0 2 2 2 2 AAA domain AAA_16 PF13191.6 CAV17556.1 - 0.00061 20.2 3.1 1 9.7 2.0 2.8 2 1 0 2 2 2 2 AAA ATPase domain RsgA_GTPase PF03193.16 CAV17556.1 - 0.00067 19.6 0.4 0.053 13.4 0.1 2.3 2 0 0 2 2 2 1 RsgA GTPase AAA_28 PF13521.6 CAV17556.1 - 0.0014 18.9 0.4 0.27 11.5 0.0 2.9 2 1 0 2 2 2 1 AAA domain SbcCD_C PF13558.6 CAV17556.1 - 0.0032 17.7 0.7 13 6.1 0.0 4.4 2 2 0 2 2 2 0 Putative exonuclease SbcCD, C subunit AAA_22 PF13401.6 CAV17556.1 - 0.0044 17.3 1.9 0.48 10.7 0.1 3.1 2 2 0 2 2 2 1 AAA domain DLIC PF05783.11 CAV17556.1 - 0.0051 15.7 0.2 0.62 8.8 0.0 2.2 2 0 0 2 2 2 1 Dynein light intermediate chain (DLIC) AAA_33 PF13671.6 CAV17556.1 - 0.006 16.7 2.9 1.5 9.0 0.1 3.0 3 1 0 3 3 2 1 AAA domain AAA_15 PF13175.6 CAV17556.1 - 0.0081 15.9 0.1 3 7.5 0.3 3.0 2 1 1 3 3 3 1 AAA ATPase domain NB-ARC PF00931.22 CAV17556.1 - 0.009 15.2 0.9 0.63 9.2 0.0 2.9 3 0 0 3 3 3 1 NB-ARC domain AAA_24 PF13479.6 CAV17556.1 - 0.0094 15.7 0.1 4.8 6.8 0.0 2.6 2 0 0 2 2 2 0 AAA domain AAA_30 PF13604.6 CAV17556.1 - 0.02 14.6 0.1 2.4 7.8 0.0 2.7 2 0 0 2 2 2 0 AAA domain Dynamin_N PF00350.23 CAV17556.1 - 0.023 14.7 3.0 0.41 10.7 0.0 2.9 3 1 0 3 3 3 0 Dynamin family Arf PF00025.21 CAV17556.1 - 0.031 13.7 0.2 5.3 6.5 0.1 2.4 2 0 0 2 2 2 0 ADP-ribosylation factor family G-alpha PF00503.20 CAV17556.1 - 0.039 13.1 0.0 2.6 7.1 0.0 2.2 2 0 0 2 2 2 0 G-protein alpha subunit AAA_14 PF13173.6 CAV17556.1 - 0.041 13.9 0.1 4.9 7.2 0.0 3.3 3 1 1 4 4 3 0 AAA domain AAA_27 PF13514.6 CAV17556.1 - 0.044 13.4 1.0 1.2 8.7 0.0 2.6 3 0 0 3 3 2 0 AAA domain ATP-synt_ab PF00006.25 CAV17556.1 - 0.047 13.4 0.2 0.46 10.1 0.0 2.2 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain AAA_25 PF13481.6 CAV17556.1 - 0.053 13.1 3.2 6.7 6.2 0.0 3.6 3 1 0 3 3 3 0 AAA domain Zeta_toxin PF06414.12 CAV17556.1 - 0.059 12.6 0.5 0.39 10.0 0.0 2.2 2 0 0 2 2 2 0 Zeta toxin Roc PF08477.13 CAV17556.1 - 0.071 13.3 0.9 8.6 6.6 0.1 3.0 3 0 0 3 3 3 0 Ras of Complex, Roc, domain of DAPkinase SRP54 PF00448.22 CAV17556.1 - 0.088 12.4 1.5 2.4 7.8 0.0 2.7 3 0 0 3 3 2 0 SRP54-type protein, GTPase domain AAA PF00004.29 CAV17556.1 - 0.095 13.1 0.0 2 8.8 0.0 2.5 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) ABC_ATPase PF09818.9 CAV17556.1 - 0.12 11.2 0.3 4.8 5.9 0.1 2.8 3 0 0 3 3 3 0 Predicted ATPase of the ABC class Ploopntkinase1 PF18748.1 CAV17556.1 - 0.13 11.7 0.0 2.8 7.4 0.0 2.2 2 0 0 2 2 2 0 P-loop Nucleotide Kinase1 NACHT PF05729.12 CAV17556.1 - 0.2 11.5 1.6 16 5.4 0.1 2.4 2 0 0 2 2 2 0 NACHT domain MRP-L46 PF11788.8 CAV17556.1 - 0.2 12.4 2.3 0.4 11.4 2.3 1.4 1 0 0 1 1 1 0 39S mitochondrial ribosomal protein L46 FtsK_SpoIIIE PF01580.18 CAV17556.1 - 0.21 10.9 0.4 19 4.5 0.0 2.4 2 0 0 2 2 2 0 FtsK/SpoIIIE family CortBP2 PF09727.9 CAV17556.1 - 0.26 11.2 3.9 0.13 12.2 0.9 1.8 2 0 0 2 2 2 0 Cortactin-binding protein-2 PRK PF00485.18 CAV17556.1 - 0.26 11.0 1.7 9.9 5.8 0.1 3.1 3 0 0 3 3 3 0 Phosphoribulokinase / Uridine kinase family cobW PF02492.19 CAV17556.1 - 0.38 10.3 3.7 11 5.6 0.4 2.7 2 1 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_13 PF13166.6 CAV17556.1 - 0.98 8.0 8.5 2.6 6.6 0.1 3.2 3 1 1 4 4 4 0 AAA domain SLT PF01464.20 CAV17557.1 - 4.1e-28 97.4 0.0 8.8e-28 96.3 0.0 1.5 1 0 0 1 1 1 1 Transglycosylase SLT domain SLT_L PF14718.6 CAV17557.1 - 1.2e-20 73.4 3.5 1.2e-20 73.4 3.5 3.7 3 1 1 4 4 4 1 Soluble lytic murein transglycosylase L domain Cucumo_coat PF00760.18 CAV17557.1 - 0.00015 21.5 0.1 0.00074 19.2 0.0 2.2 2 1 1 3 3 3 1 Cucumovirus coat protein Trp_repressor PF01371.19 CAV17558.1 - 4.6e-31 106.8 0.8 5.2e-31 106.6 0.8 1.0 1 0 0 1 1 1 1 Trp repressor protein HTH_Crp_2 PF13545.6 CAV17558.1 - 0.019 14.9 0.1 0.031 14.3 0.1 1.4 1 0 0 1 1 1 0 Crp-like helix-turn-helix domain Sigma70_r4 PF04545.16 CAV17558.1 - 0.035 13.6 0.1 0.082 12.4 0.0 1.6 2 0 0 2 2 2 0 Sigma-70, region 4 HTH_23 PF13384.6 CAV17558.1 - 0.04 13.7 0.2 0.47 10.3 0.0 2.1 2 0 0 2 2 2 0 Homeodomain-like domain HTH_3 PF01381.22 CAV17558.1 - 0.061 13.4 0.1 0.11 12.6 0.1 1.4 1 0 0 1 1 1 0 Helix-turn-helix HTH_38 PF13936.6 CAV17558.1 - 0.11 12.3 0.1 1.3 8.8 0.0 2.3 3 0 0 3 3 3 0 Helix-turn-helix domain NTPase_I-T PF01931.18 CAV17559.1 - 3.2e-58 196.1 0.0 3.6e-58 196.0 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function DUF84 EAL PF00563.20 CAV17560.1 - 3.9e-61 206.6 0.0 8.3e-61 205.5 0.0 1.5 1 0 0 1 1 1 1 EAL domain GGDEF PF00990.21 CAV17560.1 - 9.7e-39 132.7 0.1 2.9e-38 131.2 0.1 1.9 1 0 0 1 1 1 1 Diguanylate cyclase, GGDEF domain HAMP PF00672.25 CAV17560.1 - 0.00038 20.8 0.1 0.00082 19.7 0.1 1.6 1 0 0 1 1 1 1 HAMP domain Glyco_tranf_2_4 PF13704.6 CAV17560.1 - 0.099 13.2 0.1 0.42 11.2 0.1 2.2 1 0 0 1 1 1 0 Glycosyl transferase family 2 TSC22 PF01166.18 CAV17560.1 - 1.1 9.6 3.8 7.6 6.9 0.2 2.7 2 0 0 2 2 2 0 TSC-22/dip/bun family PDT PF00800.18 CAV17561.1 - 5.3e-58 195.8 0.0 8.1e-58 195.2 0.0 1.3 1 0 0 1 1 1 1 Prephenate dehydratase CM_2 PF01817.21 CAV17561.1 - 1.9e-16 60.1 1.7 3.9e-16 59.1 1.7 1.5 1 0 0 1 1 1 1 Chorismate mutase type II ACT PF01842.25 CAV17561.1 - 0.13 12.1 0.0 0.33 10.8 0.0 1.7 1 0 0 1 1 1 0 ACT domain Ribosomal_S30AE PF02482.19 CAV17562.1 - 5.7e-21 75.1 0.3 6.9e-21 74.8 0.3 1.1 1 0 0 1 1 1 1 Sigma 54 modulation protein / S30EA ribosomal protein SBP_bac_3 PF00497.20 CAV17563.1 - 2.8e-24 85.8 0.0 4.3e-24 85.2 0.0 1.3 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 SLT PF01464.20 CAV17563.1 - 9.9e-16 57.5 0.1 1.6e-15 56.8 0.1 1.4 1 0 0 1 1 1 1 Transglycosylase SLT domain Lig_chan-Glu_bd PF10613.9 CAV17563.1 - 2e-05 24.7 0.0 3.9e-05 23.8 0.0 1.5 1 0 0 1 1 1 1 Ligated ion channel L-glutamate- and glycine-binding site Glucosaminidase PF01832.20 CAV17563.1 - 0.012 16.1 0.2 0.046 14.2 0.1 2.0 2 0 0 2 2 2 0 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase LysR_substrate PF03466.20 CAV17563.1 - 0.14 11.5 0.0 0.25 10.7 0.0 1.3 1 0 0 1 1 1 0 LysR substrate binding domain YfiO PF13525.6 CAV17564.1 - 1.7e-78 263.0 1.7 2e-78 262.8 1.7 1.0 1 0 0 1 1 1 1 Outer membrane lipoprotein TPR_18 PF13512.6 CAV17564.1 - 2.1e-71 238.7 2.8 4.1e-67 224.8 0.4 2.0 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_6 PF13174.6 CAV17564.1 - 0.057 14.1 6.7 37 5.3 0.1 5.2 5 1 0 5 5 5 0 Tetratricopeptide repeat TPR_14 PF13428.6 CAV17564.1 - 0.23 12.4 9.6 8.8 7.4 0.1 4.3 4 1 1 5 5 5 0 Tetratricopeptide repeat TPR_2 PF07719.17 CAV17564.1 - 0.61 10.3 4.3 26 5.2 0.1 4.4 4 0 0 4 4 4 0 Tetratricopeptide repeat PseudoU_synth_2 PF00849.22 CAV17565.1 - 1.3e-29 103.3 0.1 2.1e-29 102.6 0.1 1.3 1 0 0 1 1 1 1 RNA pseudouridylate synthase S4 PF01479.25 CAV17565.1 - 6.9e-09 35.3 0.0 1.4e-08 34.3 0.0 1.6 1 0 0 1 1 1 1 S4 domain TruB_N PF01509.18 CAV17565.1 - 0.11 12.8 0.1 0.21 12.0 0.1 1.4 1 0 0 1 1 1 0 TruB family pseudouridylate synthase (N terminal domain) Cu-oxidase_4 PF02578.15 CAV17566.1 - 2.5e-73 246.5 0.1 2.8e-73 246.3 0.1 1.0 1 0 0 1 1 1 1 Multi-copper polyphenol oxidoreductase laccase HERV-K_REC PF15695.5 CAV17566.1 - 0.0019 18.2 0.0 0.004 17.2 0.0 1.5 1 0 0 1 1 1 1 Rec (regulator of expression encoded by corf) of HERV-K-113 AFOR_N PF02730.15 CAV17566.1 - 0.061 13.2 0.0 0.1 12.5 0.0 1.4 1 0 0 1 1 1 0 Aldehyde ferredoxin oxidoreductase, N-terminal domain TctA PF01970.16 CAV17566.1 - 0.18 10.5 0.2 0.26 10.0 0.2 1.1 1 0 0 1 1 1 0 Tripartite tricarboxylate transporter TctA family AAA_2 PF07724.14 CAV17567.1 - 4.6e-60 202.6 0.0 8e-57 192.1 0.0 2.7 2 0 0 2 2 2 2 AAA domain (Cdc48 subfamily) AAA_lid_9 PF17871.1 CAV17567.1 - 1.9e-36 124.2 4.6 1.9e-36 124.2 4.6 2.1 2 0 0 2 2 1 1 AAA lid domain Clp_N PF02861.20 CAV17567.1 - 2.1e-29 101.4 0.6 3.9e-14 52.5 0.1 3.0 2 0 0 2 2 2 2 Clp amino terminal domain, pathogenicity island component AAA PF00004.29 CAV17567.1 - 3.3e-27 95.5 0.2 3.2e-14 53.5 0.0 3.1 3 0 0 3 3 2 2 ATPase family associated with various cellular activities (AAA) ClpB_D2-small PF10431.9 CAV17567.1 - 5.6e-26 90.4 0.1 2.8e-25 88.2 0.1 2.3 1 0 0 1 1 1 1 C-terminal, D2-small domain, of ClpB protein AAA_5 PF07728.14 CAV17567.1 - 8e-19 68.0 0.9 2.3e-13 50.4 0.0 3.7 3 1 0 3 3 3 2 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 CAV17567.1 - 1.2e-10 42.0 5.0 8.1e-05 23.1 0.0 4.9 5 1 0 6 6 4 2 AAA ATPase domain AAA_22 PF13401.6 CAV17567.1 - 6.8e-09 36.1 3.1 0.0073 16.6 0.1 4.5 3 2 0 3 3 3 2 AAA domain Sigma54_activat PF00158.26 CAV17567.1 - 2.3e-08 34.0 0.0 2e-05 24.3 0.0 3.1 3 0 0 3 3 3 1 Sigma-54 interaction domain TniB PF05621.11 CAV17567.1 - 2.7e-07 30.2 0.1 0.0024 17.3 0.0 4.0 3 1 0 3 3 3 1 Bacterial TniB protein AAA_14 PF13173.6 CAV17567.1 - 4.9e-07 29.8 0.1 0.028 14.5 0.0 3.4 3 0 0 3 3 2 2 AAA domain AAA_18 PF13238.6 CAV17567.1 - 2.6e-06 28.0 0.7 0.11 13.0 0.0 3.4 3 1 0 3 3 3 2 AAA domain RuvB_N PF05496.12 CAV17567.1 - 7.2e-06 25.8 0.9 1 9.1 0.3 4.4 3 1 0 3 3 3 2 Holliday junction DNA helicase RuvB P-loop domain IstB_IS21 PF01695.17 CAV17567.1 - 8.4e-06 25.6 0.0 0.031 14.0 0.0 2.9 2 0 0 2 2 2 2 IstB-like ATP binding protein AAA_24 PF13479.6 CAV17567.1 - 9.2e-06 25.5 0.0 0.018 14.7 0.0 3.3 2 1 0 2 2 2 1 AAA domain ATPase_2 PF01637.18 CAV17567.1 - 1.4e-05 25.1 3.1 0.47 10.3 0.0 4.6 3 3 1 5 5 5 1 ATPase domain predominantly from Archaea AAA_7 PF12775.7 CAV17567.1 - 0.00012 21.6 0.0 0.16 11.5 0.0 2.5 2 0 0 2 2 2 2 P-loop containing dynein motor region RsgA_GTPase PF03193.16 CAV17567.1 - 0.00014 21.8 0.2 0.75 9.7 0.0 3.0 3 0 0 3 3 2 2 RsgA GTPase Roc PF08477.13 CAV17567.1 - 0.00021 21.5 0.0 0.54 10.5 0.0 2.6 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase RNA_helicase PF00910.22 CAV17567.1 - 0.00027 21.3 0.0 1 9.8 0.0 3.1 3 0 0 3 3 2 1 RNA helicase AAA_28 PF13521.6 CAV17567.1 - 0.00059 20.1 0.0 0.79 9.9 0.0 3.6 3 0 0 3 3 3 1 AAA domain Mg_chelatase PF01078.21 CAV17567.1 - 0.0007 19.0 0.1 2.2 7.6 0.0 3.4 2 2 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_3 PF07726.11 CAV17567.1 - 0.001 18.9 0.0 1.5 8.7 0.0 3.4 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Zeta_toxin PF06414.12 CAV17567.1 - 0.0011 18.2 0.0 2 7.6 0.0 2.7 2 0 0 2 2 2 2 Zeta toxin AAA_19 PF13245.6 CAV17567.1 - 0.0015 18.9 0.0 0.11 12.8 0.1 3.2 3 1 0 3 3 3 1 AAA domain NACHT PF05729.12 CAV17567.1 - 0.0041 17.0 0.0 0.27 11.1 0.0 2.5 2 0 0 2 2 2 1 NACHT domain ABC_tran PF00005.27 CAV17567.1 - 0.0047 17.4 2.6 1.9 9.0 0.0 4.1 3 1 0 3 3 3 1 ABC transporter NTPase_1 PF03266.15 CAV17567.1 - 0.0063 16.4 0.1 3.5 7.5 0.0 3.4 3 0 0 3 3 3 1 NTPase ATP_bind_1 PF03029.17 CAV17567.1 - 0.0082 16.0 0.0 1.3 8.7 0.0 2.9 2 0 0 2 2 2 1 Conserved hypothetical ATP binding protein DUF815 PF05673.13 CAV17567.1 - 0.0085 15.3 0.0 1.3 8.1 0.0 2.8 2 1 0 2 2 2 1 Protein of unknown function (DUF815) ResIII PF04851.15 CAV17567.1 - 0.0088 16.1 0.0 10 6.1 0.0 3.6 2 1 0 2 2 2 0 Type III restriction enzyme, res subunit TsaE PF02367.17 CAV17567.1 - 0.017 15.2 0.0 9.8 6.2 0.0 2.5 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_30 PF13604.6 CAV17567.1 - 0.029 14.1 0.2 3.2 7.4 0.1 3.6 2 2 0 2 2 2 0 AAA domain SRP54 PF00448.22 CAV17567.1 - 0.032 13.8 0.0 1.9 8.1 0.0 2.6 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain DNA_pol3_delta2 PF13177.6 CAV17567.1 - 0.034 13.9 0.0 11 5.8 0.0 2.7 3 0 0 3 3 2 0 DNA polymerase III, delta subunit AAA_29 PF13555.6 CAV17567.1 - 0.034 13.9 0.0 6.6 6.5 0.0 2.4 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA_33 PF13671.6 CAV17567.1 - 0.041 14.1 0.0 15 5.7 0.0 2.8 2 0 0 2 2 2 0 AAA domain RHH_3 PF12651.7 CAV17567.1 - 0.048 13.6 0.0 0.17 11.8 0.0 1.9 1 0 0 1 1 1 0 Ribbon-helix-helix domain MMR_HSR1 PF01926.23 CAV17567.1 - 0.054 13.6 0.0 25 5.0 0.0 3.6 3 0 0 3 3 3 0 50S ribosome-binding GTPase PduV-EutP PF10662.9 CAV17567.1 - 0.12 12.1 0.0 1.7 8.4 0.0 2.4 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_17 PF13207.6 CAV17567.1 - 0.13 12.7 2.9 22 5.5 0.0 3.8 4 0 0 4 4 3 0 AAA domain Torsin PF06309.11 CAV17567.1 - 0.15 12.2 0.0 0.76 9.9 0.0 2.0 2 0 0 2 2 2 0 Torsin AAA_11 PF13086.6 CAV17567.1 - 1.8 8.3 8.5 3.1 7.5 0.0 3.5 3 1 0 3 3 3 0 AAA domain ABC_tran_CTD PF16326.5 CAV17567.1 - 6 7.2 15.4 1.3 9.4 8.5 3.0 2 0 0 2 2 2 0 ABC transporter C-terminal domain YlqD PF11068.8 CAV17567.1 - 6.3 7.2 11.0 0.58 10.5 5.6 2.1 2 0 0 2 2 1 0 YlqD protein Peptidase_M74 PF03411.13 CAV17568.1 - 3.9e-95 318.0 0.0 4.6e-95 317.7 0.0 1.0 1 0 0 1 1 1 1 Penicillin-insensitive murein endopeptidase VanY PF02557.17 CAV17568.1 - 0.032 14.0 0.0 0.055 13.3 0.0 1.4 1 0 0 1 1 1 0 D-alanyl-D-alanine carboxypeptidase Fer4_2 PF12797.7 CAV17570.1 - 3.5e-07 29.9 11.2 0.00018 21.4 1.6 2.4 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_7 PF12838.7 CAV17570.1 - 2e-06 28.3 11.8 3.8e-06 27.4 11.8 1.5 1 1 0 1 1 1 1 4Fe-4S dicluster domain Fer4 PF00037.27 CAV17570.1 - 3.4e-06 26.6 9.5 6.2e-06 25.8 3.6 3.4 4 0 0 4 4 4 2 4Fe-4S binding domain Fer4_21 PF14697.6 CAV17570.1 - 0.00034 20.7 17.7 0.0018 18.4 17.7 2.2 1 1 0 1 1 1 1 4Fe-4S dicluster domain Fer4_9 PF13187.6 CAV17570.1 - 0.0007 19.7 12.8 0.0019 18.3 13.0 1.6 1 1 0 1 1 1 1 4Fe-4S dicluster domain Fer4_10 PF13237.6 CAV17570.1 - 0.0007 19.7 15.9 0.0047 17.0 14.7 2.3 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_6 PF12837.7 CAV17570.1 - 0.023 14.8 19.6 0.36 11.0 5.8 2.7 2 1 0 2 2 2 0 4Fe-4S binding domain GF_recep_IV PF14843.6 CAV17570.1 - 0.026 14.3 9.7 0.037 13.8 9.7 1.4 1 1 0 1 1 1 0 Growth factor receptor domain IV Fer4_16 PF13484.6 CAV17570.1 - 0.027 15.4 4.8 0.027 15.4 4.8 2.3 1 1 1 2 2 2 0 4Fe-4S double cluster binding domain Fer4_17 PF13534.6 CAV17570.1 - 0.13 12.8 4.5 0.13 12.8 4.5 2.5 1 1 1 3 3 3 0 4Fe-4S dicluster domain Fer4_8 PF13183.6 CAV17570.1 - 0.15 12.6 15.3 0.25 11.8 3.5 2.2 1 1 2 3 3 3 0 4Fe-4S dicluster domain Fer4_4 PF12800.7 CAV17570.1 - 0.16 12.5 16.1 0.58 10.8 2.1 2.5 2 1 0 2 2 2 0 4Fe-4S binding domain Fer4_3 PF12798.7 CAV17570.1 - 9.1 7.5 18.7 12 7.1 4.6 2.3 2 0 0 2 2 2 0 4Fe-4S binding domain Peptidase_U32 PF01136.19 CAV17571.1 - 7.3e-97 323.1 0.1 2.2e-96 321.5 0.1 1.7 1 1 0 1 1 1 1 Peptidase family U32 Peptidase_U32_C PF16325.5 CAV17571.1 - 6.1e-20 71.3 1.0 1.3e-19 70.2 0.0 2.1 3 0 0 3 3 3 1 Peptidase family U32 C-terminal domain Tachystatin_B PF11478.8 CAV17571.1 - 0.26 11.3 3.6 0.13 12.2 0.5 2.0 2 0 0 2 2 2 0 Antimicrobial chitin binding protein tachystatin B RdgC PF04381.12 CAV17572.1 - 2.4e-121 404.6 0.3 2.7e-121 404.5 0.3 1.0 1 0 0 1 1 1 1 Putative exonuclease, RdgC Response_reg PF00072.24 CAV17573.1 - 3.5e-29 101.2 0.0 5.4e-29 100.6 0.0 1.3 1 0 0 1 1 1 1 Response regulator receiver domain Trans_reg_C PF00486.28 CAV17573.1 - 3.3e-28 97.6 0.0 6.6e-28 96.6 0.0 1.5 1 0 0 1 1 1 1 Transcriptional regulatory protein, C terminal PhoR PF11808.8 CAV17574.1 - 5.9e-32 109.9 10.8 1.3e-31 108.9 10.8 1.6 1 0 0 1 1 1 1 Phosphate regulon sensor protein PhoR HATPase_c PF02518.26 CAV17574.1 - 1.1e-23 83.9 0.0 1.6e-23 83.3 0.0 1.3 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 CAV17574.1 - 7.7e-16 57.9 0.0 2.2e-15 56.4 0.0 1.8 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain PAS PF00989.25 CAV17574.1 - 4.4e-08 33.1 0.0 3.5e-07 30.2 0.0 2.4 2 1 1 3 3 3 1 PAS fold HATPase_c_2 PF13581.6 CAV17574.1 - 1.3e-05 25.2 0.0 2.9e-05 24.0 0.0 1.6 2 0 0 2 2 2 1 Histidine kinase-like ATPase domain PAS_8 PF13188.7 CAV17574.1 - 0.00019 21.3 0.0 0.00067 19.6 0.0 1.9 2 0 0 2 2 2 1 PAS domain PAS_4 PF08448.10 CAV17574.1 - 0.00087 19.5 0.2 0.047 14.0 0.1 3.1 2 1 0 2 2 2 1 PAS fold HATPase_c_3 PF13589.6 CAV17574.1 - 0.0029 17.5 0.0 0.0047 16.7 0.0 1.3 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase PAS_9 PF13426.7 CAV17574.1 - 0.043 14.1 0.0 0.088 13.1 0.0 1.6 1 0 0 1 1 1 0 PAS domain PBP_like_2 PF12849.7 CAV17575.1 - 1.7e-27 96.8 0.0 3.2e-27 95.9 0.0 1.4 1 1 0 1 1 1 1 PBP superfamily domain PBP_like PF12727.7 CAV17575.1 - 6.4e-11 41.7 0.0 9.4e-11 41.2 0.0 1.3 1 0 0 1 1 1 1 PBP superfamily domain SBP_bac_11 PF13531.6 CAV17575.1 - 0.0011 18.8 0.0 0.0046 16.7 0.0 1.9 1 1 0 1 1 1 1 Bacterial extracellular solute-binding protein Ppx-GppA PF02541.16 CAV17576.1 - 1.4e-85 287.2 0.0 1.9e-85 286.8 0.0 1.2 1 0 0 1 1 1 1 Ppx/GppA phosphatase family FtsA PF14450.6 CAV17576.1 - 0.0018 18.7 0.0 0.031 14.7 0.0 2.4 2 1 0 2 2 2 1 Cell division protein FtsA HD PF01966.22 CAV17576.1 - 0.045 14.0 0.1 0.12 12.6 0.0 1.7 2 0 0 2 2 2 0 HD domain PP_kinase_C_1 PF17941.1 CAV17577.1 - 1.2e-70 236.4 1.8 1.2e-70 236.4 1.8 1.9 2 0 0 2 2 2 1 Polyphosphate kinase C-terminal domain 1 PP_kinase_C PF13090.6 CAV17577.1 - 1.3e-64 216.8 1.7 3.7e-64 215.3 0.2 2.2 2 0 0 2 2 2 1 Polyphosphate kinase C-terminal domain 2 PP_kinase PF02503.17 CAV17577.1 - 2.9e-45 154.4 0.4 6e-45 153.3 0.4 1.6 1 0 0 1 1 1 1 Polyphosphate kinase middle domain PP_kinase_N PF13089.6 CAV17577.1 - 3.4e-30 104.5 0.8 3.4e-30 104.5 0.8 2.6 3 0 0 3 3 3 1 Polyphosphate kinase N-terminal domain PLDc_2 PF13091.6 CAV17577.1 - 3e-16 59.5 4.1 1.9e-10 40.7 0.6 2.8 3 0 0 3 3 3 2 PLD-like domain Pyr_redox PF00070.27 CAV17577.1 - 0.044 14.3 0.0 0.25 11.9 0.0 2.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase MR_MLE_C PF13378.6 CAV17577.1 - 0.093 12.3 0.0 0.16 11.5 0.0 1.2 1 0 0 1 1 1 0 Enolase C-terminal domain-like BEN PF10523.9 CAV17577.1 - 0.12 12.7 0.0 0.37 11.1 0.0 1.8 1 0 0 1 1 1 0 BEN domain BPD_transp_1 PF00528.22 CAV17578.1 - 5.1e-12 45.9 32.7 5.3e-10 39.3 29.9 3.0 2 1 0 2 2 2 1 Binding-protein-dependent transport system inner membrane component BPD_transp_1 PF00528.22 CAV17579.1 - 5.4e-18 65.4 13.8 5.4e-18 65.4 13.8 2.7 2 1 1 3 3 3 1 Binding-protein-dependent transport system inner membrane component ABC_tran PF00005.27 CAV17580.1 - 1.6e-32 112.8 0.0 2.3e-32 112.4 0.0 1.2 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 CAV17580.1 - 7.6e-12 45.6 0.0 1.9e-05 24.6 0.0 2.1 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system RsgA_GTPase PF03193.16 CAV17580.1 - 1.4e-06 28.4 0.1 3.5e-06 27.0 0.0 1.7 2 0 0 2 2 2 1 RsgA GTPase SMC_N PF02463.19 CAV17580.1 - 2.3e-06 27.2 0.1 7e-05 22.4 0.1 2.1 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 CAV17580.1 - 6.2e-06 26.5 0.0 3.7e-05 24.0 0.0 2.1 1 1 0 1 1 1 1 AAA domain AAA_23 PF13476.6 CAV17580.1 - 0.00014 22.4 0.0 0.00026 21.6 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 CAV17580.1 - 0.00018 21.9 0.1 0.00074 19.9 0.1 1.9 1 1 0 1 1 1 1 AAA ATPase domain ABC_ATPase PF09818.9 CAV17580.1 - 0.00019 20.4 0.0 0.093 11.5 0.0 2.1 2 0 0 2 2 2 2 Predicted ATPase of the ABC class AAA_29 PF13555.6 CAV17580.1 - 0.00041 20.0 0.0 0.00089 18.9 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_25 PF13481.6 CAV17580.1 - 0.0015 18.2 0.0 0.0032 17.1 0.0 1.7 1 1 0 1 1 1 1 AAA domain AAA_15 PF13175.6 CAV17580.1 - 0.0017 18.2 0.0 0.0041 16.9 0.0 1.4 1 1 0 2 2 2 1 AAA ATPase domain AAA_30 PF13604.6 CAV17580.1 - 0.014 15.1 0.2 0.76 9.5 0.0 2.1 2 0 0 2 2 2 0 AAA domain Rad17 PF03215.15 CAV17580.1 - 0.022 14.7 0.0 0.036 14.0 0.0 1.4 1 0 0 1 1 1 0 Rad17 P-loop domain NB-ARC PF00931.22 CAV17580.1 - 0.022 14.0 0.1 0.027 13.7 0.1 1.4 1 1 0 1 1 1 0 NB-ARC domain AAA PF00004.29 CAV17580.1 - 0.037 14.4 0.1 0.75 10.2 0.0 2.3 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_33 PF13671.6 CAV17580.1 - 0.059 13.5 0.0 0.13 12.4 0.0 1.7 1 0 0 1 1 1 0 AAA domain ATP-synt_ab PF00006.25 CAV17580.1 - 0.064 12.9 0.3 0.22 11.2 0.3 1.9 1 1 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain Adeno_IVa2 PF02456.15 CAV17580.1 - 0.077 11.8 0.2 0.81 8.4 0.0 2.0 2 0 0 2 2 2 0 Adenovirus IVa2 protein PhoU PF01895.19 CAV17581.1 - 1.3e-39 134.5 7.3 1e-22 80.4 1.0 2.1 2 0 0 2 2 2 2 PhoU domain HATPase_c_2 PF13581.6 CAV17581.1 - 0.15 12.0 0.5 0.4 10.6 0.1 1.9 1 1 1 2 2 2 0 Histidine kinase-like ATPase domain SKA2 PF16740.5 CAV17581.1 - 0.3 10.9 2.4 0.53 10.1 0.2 2.1 2 1 0 2 2 2 0 Spindle and kinetochore-associated protein 2 KdgM PF06178.13 CAV17582.1 - 0.042 13.5 0.1 0.057 13.0 0.1 1.2 1 0 0 1 1 1 0 Oligogalacturonate-specific porin protein (KdgM) GA PF01468.17 CAV17583.1 - 0.1 12.9 0.1 0.19 12.0 0.1 1.4 1 0 0 1 1 1 0 GA module HTH_1 PF00126.27 CAV17584.1 - 5.1e-17 61.6 0.1 9e-17 60.8 0.1 1.4 1 0 0 1 1 1 1 Bacterial regulatory helix-turn-helix protein, lysR family LysR_substrate PF03466.20 CAV17584.1 - 5.7e-07 29.1 0.0 8.2e-07 28.6 0.0 1.3 1 0 0 1 1 1 1 LysR substrate binding domain HTH_30 PF13556.6 CAV17584.1 - 0.025 14.4 0.1 0.049 13.4 0.1 1.4 1 0 0 1 1 1 0 PucR C-terminal helix-turn-helix domain HTH_50 PF18024.1 CAV17584.1 - 0.058 13.0 0.0 0.12 12.0 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain Fe_dep_repress PF01325.19 CAV17584.1 - 0.07 13.3 0.0 0.17 12.1 0.0 1.6 1 0 0 1 1 1 0 Iron dependent repressor, N-terminal DNA binding domain HTH_37 PF13744.6 CAV17584.1 - 0.088 12.8 0.1 7.6 6.6 0.0 2.5 2 0 0 2 2 2 0 Helix-turn-helix domain CutC PF03932.14 CAV17585.1 - 2.8e-76 255.5 0.7 3.3e-76 255.3 0.7 1.0 1 0 0 1 1 1 1 CutC family DHDPS PF00701.22 CAV17585.1 - 0.036 12.8 0.1 0.062 12.0 0.1 1.3 1 0 0 1 1 1 0 Dihydrodipicolinate synthetase family AIRC PF00731.20 CAV17585.1 - 0.12 11.9 2.2 0.18 11.4 0.7 2.0 1 1 1 2 2 2 0 AIR carboxylase AhpC-TSA PF00578.21 CAV17586.1 - 6e-34 116.6 0.0 2e-33 114.9 0.0 1.7 2 0 0 2 2 2 1 AhpC/TSA family Redoxin PF08534.10 CAV17586.1 - 3.6e-17 62.4 0.0 4.7e-17 62.1 0.0 1.1 1 0 0 1 1 1 1 Redoxin 1-cysPrx_C PF10417.9 CAV17586.1 - 6.4e-08 32.3 0.0 1.1e-07 31.5 0.0 1.4 1 0 0 1 1 1 1 C-terminal domain of 1-Cys peroxiredoxin LysR_substrate PF03466.20 CAV17587.1 - 3.3e-38 131.2 0.2 4.2e-38 130.8 0.2 1.1 1 0 0 1 1 1 1 LysR substrate binding domain HTH_1 PF00126.27 CAV17587.1 - 6.7e-16 58.0 0.0 1.4e-15 56.9 0.0 1.6 1 0 0 1 1 1 1 Bacterial regulatory helix-turn-helix protein, lysR family HTH_30 PF13556.6 CAV17587.1 - 0.0035 17.1 0.0 0.011 15.6 0.0 1.7 1 0 0 1 1 1 1 PucR C-terminal helix-turn-helix domain MCPsignal PF00015.21 CAV17588.1 - 1.1e-41 142.5 19.7 1.1e-41 142.5 19.7 3.6 2 1 1 3 3 3 1 Methyl-accepting chemotaxis protein (MCP) signalling domain BLOC1_2 PF10046.9 CAV17588.1 - 0.076 13.3 22.9 0.066 13.5 1.1 5.0 4 1 1 5 5 5 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 HAMP PF00672.25 CAV17588.1 - 0.082 13.3 0.3 9.1 6.7 0.0 4.0 4 1 0 4 4 4 0 HAMP domain PRANC PF09372.10 CAV17588.1 - 0.15 12.4 1.0 2.3 8.6 0.1 2.7 2 0 0 2 2 2 0 PRANC domain DUF948 PF06103.11 CAV17588.1 - 0.31 11.3 23.6 0.36 11.1 0.5 5.2 3 1 0 4 4 4 0 Bacterial protein of unknown function (DUF948) Jnk-SapK_ap_N PF09744.9 CAV17588.1 - 0.66 10.2 15.1 4.4 7.5 5.6 3.0 2 1 0 2 2 2 0 JNK_SAPK-associated protein-1 PA28_beta PF02252.18 CAV17588.1 - 1.1 9.0 5.5 0.4 10.3 1.4 2.3 2 1 0 2 2 2 0 Proteasome activator pa28 beta subunit CRIC_ras_sig PF10534.9 CAV17588.1 - 2.8 8.2 6.6 53 4.1 0.0 3.9 3 2 0 4 4 4 0 Connector enhancer of kinase suppressor of ras 4HB_MCP_1 PF12729.7 CAV17589.1 - 2.3e-10 40.3 1.6 3.1e-10 39.9 1.6 1.1 1 0 0 1 1 1 1 Four helix bundle sensory module for signal transduction Sigma54_CBD PF04963.13 CAV17589.1 - 0.015 15.2 0.6 0.45 10.3 0.4 2.1 1 1 1 2 2 2 0 Sigma-54 factor, core binding domain Flg_bbr_C PF06429.13 CAV17589.1 - 0.082 13.1 1.4 0.12 12.6 0.4 1.8 2 0 0 2 2 2 0 Flagellar basal body rod FlgEFG protein C-terminal CBS PF00571.28 CAV17590.1 - 2.7e-25 88.6 1.4 9e-13 48.5 0.2 2.1 2 0 0 2 2 2 2 CBS domain FAM216B PF15107.6 CAV17590.1 - 0.031 14.1 0.0 0.11 12.4 0.1 1.9 2 0 0 2 2 2 0 FAM216B protein family Queuosine_synth PF02547.15 CAV17591.1 - 8.5e-134 445.8 0.0 9.5e-134 445.6 0.0 1.0 1 0 0 1 1 1 1 Queuosine biosynthesis protein TGT PF01702.18 CAV17592.1 - 1.5e-156 520.9 0.0 1.8e-156 520.7 0.0 1.0 1 0 0 1 1 1 1 Queuine tRNA-ribosyltransferase YajC PF02699.15 CAV17593.1 - 1.1e-25 89.3 0.4 1.3e-25 89.0 0.4 1.1 1 0 0 1 1 1 1 Preprotein translocase subunit SecD-TM1 PF13721.6 CAV17594.1 - 1.3e-39 134.8 8.3 1.4e-37 128.3 0.1 3.5 5 0 0 5 5 5 2 SecD export protein N-terminal TM region SecD_SecF PF02355.16 CAV17594.1 - 3.5e-19 68.9 11.5 6.7e-19 68.0 11.5 1.4 1 0 0 1 1 1 1 Protein export membrane protein MMPL PF03176.15 CAV17594.1 - 4.2e-08 32.5 16.6 4.2e-08 32.5 16.6 2.4 3 0 0 3 3 3 1 MMPL family Sec_GG PF07549.14 CAV17594.1 - 2e-07 30.3 0.0 4.3e-07 29.2 0.0 1.6 1 0 0 1 1 1 1 SecD/SecF GG Motif Carot_N PF09150.10 CAV17594.1 - 0.12 12.3 0.0 0.3 10.9 0.0 1.7 1 0 0 1 1 1 0 Orange carotenoid protein, N-terminal SecD_SecF PF02355.16 CAV17595.1 - 4e-71 238.3 10.6 5.8e-71 237.8 10.6 1.2 1 0 0 1 1 1 1 Protein export membrane protein Sec_GG PF07549.14 CAV17595.1 - 3.4e-10 39.1 0.2 1.1e-09 37.5 0.2 2.0 1 0 0 1 1 1 1 SecD/SecF GG Motif Peptidase_M19 PF01244.21 CAV17595.1 - 0.013 14.7 0.0 0.019 14.1 0.0 1.2 1 0 0 1 1 1 0 Membrane dipeptidase (Peptidase family M19) DUF2721 PF11026.8 CAV17595.1 - 2 8.3 16.2 0.1 12.5 1.4 3.1 2 1 1 3 3 3 0 Protein of unknown function (DUF2721) Inositol_P PF00459.25 CAV17597.1 - 7.2e-66 222.5 0.0 8.3e-66 222.3 0.0 1.0 1 0 0 1 1 1 1 Inositol monophosphatase family Cas_Cas02710 PF09670.10 CAV17597.1 - 0.16 10.7 0.9 0.26 10.1 0.1 1.7 3 0 0 3 3 3 0 CRISPR-associated protein (Cas_Cas02710) SpoU_methylase PF00588.19 CAV17598.1 - 1.1e-34 119.7 0.0 1.8e-34 118.9 0.0 1.4 1 0 0 1 1 1 1 SpoU rRNA Methylase family OTCace PF00185.24 CAV17598.1 - 0.041 13.9 0.1 0.1 12.6 0.0 1.7 2 0 0 2 2 2 0 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain Rrf2 PF02082.20 CAV17599.1 - 3.9e-28 97.6 0.1 8.2e-28 96.6 0.1 1.6 1 0 0 1 1 1 1 Transcriptional regulator HrcA_DNA-bdg PF03444.15 CAV17599.1 - 0.00087 18.9 0.0 0.0013 18.4 0.0 1.3 1 0 0 1 1 1 1 Winged helix-turn-helix transcription repressor, HrcA DNA-binding MarR_2 PF12802.7 CAV17599.1 - 0.0017 18.2 0.0 0.0035 17.2 0.0 1.5 1 0 0 1 1 1 1 MarR family HTH_24 PF13412.6 CAV17599.1 - 0.0083 15.7 0.0 0.087 12.4 0.0 2.3 2 0 0 2 2 2 1 Winged helix-turn-helix DNA-binding HTH_20 PF12840.7 CAV17599.1 - 0.018 15.1 0.0 0.033 14.3 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_AraC PF00165.23 CAV17599.1 - 0.13 12.4 0.0 0.25 11.5 0.0 1.6 1 0 0 1 1 1 0 Bacterial regulatory helix-turn-helix proteins, AraC family HTH_11 PF08279.12 CAV17599.1 - 0.14 12.2 0.0 0.47 10.4 0.0 1.9 2 0 0 2 2 2 0 HTH domain Aminotran_5 PF00266.19 CAV17600.1 - 1.3e-87 294.2 0.0 1.5e-87 294.0 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.21 CAV17600.1 - 4.4e-09 36.0 0.4 5.4e-09 35.7 0.4 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase Aminotran_1_2 PF00155.21 CAV17600.1 - 6.1e-09 35.5 0.0 1.4e-08 34.4 0.0 1.6 2 0 0 2 2 2 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.20 CAV17600.1 - 7.2e-05 21.5 0.0 0.00012 20.7 0.0 1.3 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme DegT_DnrJ_EryC1 PF01041.17 CAV17600.1 - 0.00016 21.1 0.0 0.00028 20.3 0.0 1.3 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Ribosomal_S24e PF01282.19 CAV17600.1 - 0.043 13.8 0.0 0.11 12.5 0.0 1.7 1 0 0 1 1 1 0 Ribosomal protein S24e Pyridoxal_deC PF00282.19 CAV17600.1 - 0.095 11.4 0.0 0.15 10.8 0.0 1.2 1 0 0 1 1 1 0 Pyridoxal-dependent decarboxylase conserved domain NifU_N PF01592.16 CAV17601.1 - 1.2e-56 190.4 0.3 1.3e-56 190.3 0.3 1.0 1 0 0 1 1 1 1 NifU-like N terminal domain MurB_C PF02873.16 CAV17601.1 - 0.091 12.8 0.0 0.13 12.3 0.0 1.4 1 0 0 1 1 1 0 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain Fe-S_biosyn PF01521.20 CAV17602.1 - 2.9e-27 95.1 0.0 3.2e-27 94.9 0.0 1.0 1 0 0 1 1 1 1 Iron-sulphur cluster biosynthesis HSCB_C PF07743.13 CAV17603.1 - 2.7e-19 69.4 7.4 2.7e-19 69.4 7.4 1.6 2 0 0 2 2 2 1 HSCB C-terminal oligomerisation domain DnaJ PF00226.31 CAV17603.1 - 1.4e-07 31.5 0.0 2.5e-07 30.7 0.0 1.4 1 0 0 1 1 1 1 DnaJ domain HSP70 PF00012.20 CAV17604.1 - 1.9e-191 637.4 1.6 2.1e-191 637.2 1.6 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 CAV17604.1 - 2e-14 53.2 1.1 7.4e-13 48.0 0.3 2.3 2 0 0 2 2 2 2 MreB/Mbl protein FGGY_C PF02782.16 CAV17604.1 - 0.002 17.9 0.0 0.0051 16.6 0.0 1.7 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain Fer2 PF00111.27 CAV17605.1 - 2.2e-14 53.2 3.1 3e-14 52.7 3.1 1.1 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain Secretogranin_V PF05281.11 CAV17605.1 - 0.098 12.3 0.1 0.11 12.1 0.1 1.1 1 0 0 1 1 1 0 Neuroendocrine protein 7B2 precursor (Secretogranin V) Fer2_4 PF13510.6 CAV17605.1 - 0.11 12.6 1.5 0.3 11.2 1.5 1.7 1 1 0 1 1 1 0 2Fe-2S iron-sulfur cluster binding domain TGS PF02824.21 CAV17605.1 - 0.11 12.5 0.0 0.24 11.5 0.0 1.5 1 0 0 1 1 1 0 TGS domain Fe-S_assembly PF04384.13 CAV17606.1 - 4.5e-32 110.5 3.4 4.9e-32 110.3 3.4 1.0 1 0 0 1 1 1 1 Iron-sulphur cluster assembly Peptidase_M17 PF00883.21 CAV17607.1 - 3.9e-103 345.0 0.3 4.7e-103 344.7 0.3 1.1 1 0 0 1 1 1 1 Cytosol aminopeptidase family, catalytic domain DUF3663 PF12404.8 CAV17607.1 - 1.1e-31 108.7 0.1 2.7e-31 107.5 0.1 1.7 1 0 0 1 1 1 1 Peptidase NDK PF00334.19 CAV17608.1 - 4.7e-57 191.8 0.0 5.2e-57 191.6 0.0 1.0 1 0 0 1 1 1 1 Nucleoside diphosphate kinase Radical_SAM PF04055.21 CAV17609.1 - 8.9e-15 55.5 0.0 1.6e-14 54.6 0.0 1.5 1 0 0 1 1 1 1 Radical SAM superfamily Fer4_14 PF13394.6 CAV17609.1 - 0.00018 21.6 0.0 0.0004 20.5 0.0 1.5 1 0 0 1 1 1 1 4Fe-4S single cluster domain Fer4_12 PF13353.6 CAV17609.1 - 0.011 16.0 0.0 0.036 14.3 0.0 1.8 2 0 0 2 2 2 0 4Fe-4S single cluster domain FRP PF18032.1 CAV17609.1 - 0.02 15.5 0.0 0.039 14.6 0.0 1.5 1 0 0 1 1 1 0 Photoprotection regulator fluorescence recovery protein DUF4115 PF13464.6 CAV17611.1 - 5.7e-26 90.5 0.3 1.2e-24 86.3 0.0 2.8 3 0 0 3 3 3 1 Domain of unknown function (DUF4115) HTH_25 PF13413.6 CAV17611.1 - 6.6e-18 64.3 0.2 1.1e-17 63.6 0.2 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_19 PF12844.7 CAV17611.1 - 4.2e-05 23.5 0.3 7.9e-05 22.6 0.3 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_3 PF01381.22 CAV17611.1 - 0.00023 21.2 0.6 0.00059 19.8 0.6 1.7 1 0 0 1 1 1 1 Helix-turn-helix HTH_31 PF13560.6 CAV17611.1 - 0.013 15.9 0.5 0.11 12.9 0.0 2.4 2 0 0 2 2 2 0 Helix-turn-helix domain Equine_IAV_S2 PF06502.11 CAV17611.1 - 0.12 12.5 0.8 0.24 11.5 0.8 1.5 1 0 0 1 1 1 0 Equine infectious anaemia virus S2 protein Mucin PF01456.17 CAV17611.1 - 0.21 11.6 8.6 0.45 10.5 8.6 1.5 1 0 0 1 1 1 0 Mucin-like glycoprotein DUF4366 PF14283.6 CAV17611.1 - 0.82 9.7 8.0 29 4.7 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4366) GcpE PF04551.14 CAV17613.1 - 3.7e-131 437.4 0.2 4.2e-131 437.2 0.2 1.0 1 0 0 1 1 1 1 GcpE protein DeoC PF01791.9 CAV17613.1 - 0.027 14.1 0.1 0.83 9.2 0.1 2.3 1 1 1 2 2 2 0 DeoC/LacD family aldolase Robl_LC7 PF03259.17 CAV17613.1 - 0.072 12.9 0.1 0.15 11.8 0.1 1.4 1 0 0 1 1 1 0 Roadblock/LC7 domain Ribosomal_S3Ae PF01015.18 CAV17613.1 - 0.087 12.4 0.0 0.15 11.6 0.0 1.3 1 0 0 1 1 1 0 Ribosomal S3Ae family tRNA-synt_His PF13393.6 CAV17615.1 - 1.6e-45 155.8 0.0 2.3e-45 155.2 0.0 1.3 1 0 0 1 1 1 1 Histidyl-tRNA synthetase tRNA-synt_2b PF00587.25 CAV17615.1 - 1.1e-32 113.4 0.0 2.1e-32 112.5 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.20 CAV17615.1 - 6.5e-10 39.0 0.1 1.3e-09 38.1 0.1 1.5 1 0 0 1 1 1 1 Anticodon binding domain tRNA-synt_2d PF01409.20 CAV17615.1 - 3.7e-05 23.3 0.0 0.00088 18.8 0.0 2.1 2 0 0 2 2 2 1 tRNA synthetases class II core domain (F) tRNA-synt_2 PF00152.20 CAV17615.1 - 7.9e-05 21.9 0.0 0.0054 15.8 0.0 2.7 1 1 0 1 1 1 1 tRNA synthetases class II (D, K and N) TPR_21 PF09976.9 CAV17616.1 - 5.6e-54 182.8 17.4 6.4e-54 182.6 17.4 1.0 1 0 0 1 1 1 1 Tetratricopeptide repeat-like domain TPR_14 PF13428.6 CAV17616.1 - 0.00023 21.7 13.3 0.38 11.7 3.1 3.6 1 1 2 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.6 CAV17616.1 - 0.00055 20.5 15.8 0.0031 18.1 4.6 3.0 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_9 PF13371.6 CAV17616.1 - 0.0052 16.9 9.2 0.13 12.4 1.0 3.7 1 1 2 3 3 3 2 Tetratricopeptide repeat YcaO_C PF18381.1 CAV17616.1 - 0.0059 16.5 1.1 0.17 11.8 0.3 2.1 2 0 0 2 2 2 1 YcaO cyclodehydratase C-terminal domain TPR_2 PF07719.17 CAV17616.1 - 0.0084 16.1 5.3 4.4 7.7 0.2 3.9 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_8 PF13181.6 CAV17616.1 - 0.14 12.4 7.1 2.8 8.4 0.1 4.1 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_19 PF14559.6 CAV17616.1 - 0.8 10.3 19.9 1.4 9.5 3.3 3.4 1 1 1 3 3 3 0 Tetratricopeptide repeat TPR_1 PF00515.28 CAV17616.1 - 1.2 9.1 7.4 28 4.8 0.1 3.9 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_4 PF07721.14 CAV17616.1 - 1.2 10.0 13.9 0.82 10.5 2.7 3.9 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_20 PF14561.6 CAV17616.1 - 3 8.2 10.7 2.1 8.7 4.1 3.0 1 1 2 3 3 3 0 Tetratricopeptide repeat TPR_6 PF13174.6 CAV17616.1 - 5.4 7.9 11.5 44 5.0 0.1 3.9 3 1 0 3 3 3 0 Tetratricopeptide repeat PQQ_2 PF13360.6 CAV17617.1 - 1.9e-61 207.7 12.6 1.9e-54 184.8 8.2 2.4 1 1 1 2 2 2 2 PQQ-like domain PQQ PF01011.21 CAV17617.1 - 1e-39 132.6 0.7 6.5e-09 35.3 0.0 7.5 7 1 0 7 7 7 6 PQQ enzyme repeat PQQ_3 PF13570.6 CAV17617.1 - 8.8e-37 124.7 15.4 1e-05 25.9 0.0 7.9 7 1 0 7 7 7 7 PQQ-like domain Mcl1_mid PF12341.8 CAV17617.1 - 0.025 14.0 0.0 0.27 10.5 0.0 2.3 2 0 0 2 2 2 0 Minichromosome loss protein, Mcl1, middle region MMR_HSR1 PF01926.23 CAV17618.1 - 4e-54 181.6 0.4 4.4e-27 94.4 0.0 2.4 2 0 0 2 2 2 2 50S ribosome-binding GTPase FeoB_N PF02421.18 CAV17618.1 - 2.9e-32 111.4 0.0 4.4e-17 62.0 0.0 2.2 2 0 0 2 2 2 2 Ferrous iron transport protein B KH_dom-like PF14714.6 CAV17618.1 - 1.4e-25 89.4 0.0 9.2e-25 86.8 0.1 2.1 2 0 0 2 2 2 1 KH-domain-like of EngA bacterial GTPase enzymes, C-terminal GTP_EFTU PF00009.27 CAV17618.1 - 1.1e-18 67.5 3.1 6e-09 35.7 0.1 5.0 3 2 0 3 3 3 2 Elongation factor Tu GTP binding domain Dynamin_N PF00350.23 CAV17618.1 - 4.6e-11 43.1 5.4 0.041 13.9 0.0 4.8 5 1 1 6 6 4 3 Dynamin family RsgA_GTPase PF03193.16 CAV17618.1 - 6.6e-09 35.9 0.0 0.0083 16.0 0.0 4.2 3 1 1 4 4 4 2 RsgA GTPase AIG1 PF04548.16 CAV17618.1 - 4.9e-08 32.6 0.0 0.00017 21.0 0.0 2.4 2 0 0 2 2 2 2 AIG1 family cobW PF02492.19 CAV17618.1 - 2.6e-07 30.4 4.5 0.00099 18.7 0.1 3.6 2 2 0 3 3 3 2 CobW/HypB/UreG, nucleotide-binding domain PduV-EutP PF10662.9 CAV17618.1 - 1.5e-06 28.0 0.0 0.042 13.6 0.0 3.2 2 2 0 2 2 2 2 Ethanolamine utilisation - propanediol utilisation Ras PF00071.22 CAV17618.1 - 3e-06 26.9 0.0 0.0091 15.6 0.0 3.1 2 2 0 2 2 2 2 Ras family Roc PF08477.13 CAV17618.1 - 4.5e-06 26.9 0.1 0.19 11.9 0.0 3.6 3 2 0 3 3 2 2 Ras of Complex, Roc, domain of DAPkinase ATP_bind_1 PF03029.17 CAV17618.1 - 1e-05 25.4 0.0 0.046 13.5 0.0 4.0 3 1 0 4 4 4 1 Conserved hypothetical ATP binding protein ABC_tran PF00005.27 CAV17618.1 - 5.1e-05 23.8 0.0 0.28 11.7 0.0 2.6 2 0 0 2 2 2 2 ABC transporter AAA_24 PF13479.6 CAV17618.1 - 9.8e-05 22.2 0.0 0.26 11.0 0.0 2.9 2 2 0 2 2 2 2 AAA domain AAA_22 PF13401.6 CAV17618.1 - 0.00012 22.4 0.1 1.3 9.3 0.0 3.3 2 2 0 2 2 2 2 AAA domain TniB PF05621.11 CAV17618.1 - 0.0003 20.3 0.0 0.24 10.8 0.1 2.4 2 0 0 2 2 2 2 Bacterial TniB protein SRP54 PF00448.22 CAV17618.1 - 0.00049 19.8 0.2 0.88 9.2 0.0 2.8 3 0 0 3 3 3 2 SRP54-type protein, GTPase domain SRPRB PF09439.10 CAV17618.1 - 0.00079 18.9 0.5 0.24 10.8 0.0 3.1 2 1 1 3 3 3 1 Signal recognition particle receptor beta subunit NB-ARC PF00931.22 CAV17618.1 - 0.0017 17.6 0.0 1.2 8.2 0.0 2.5 2 0 0 2 2 2 2 NB-ARC domain RNA_helicase PF00910.22 CAV17618.1 - 0.003 17.9 0.0 4.3 7.8 0.0 2.6 2 0 0 2 2 2 1 RNA helicase Nuc_deoxyri_tr2 PF15891.5 CAV17618.1 - 0.0031 17.8 0.1 4 7.8 0.0 2.5 2 0 0 2 2 2 2 Nucleoside 2-deoxyribosyltransferase like NTPase_1 PF03266.15 CAV17618.1 - 0.0047 16.8 0.0 5.9 6.8 0.0 2.9 2 0 0 2 2 2 0 NTPase MeaB PF03308.16 CAV17618.1 - 0.006 15.6 2.6 6.6 5.6 0.0 4.2 3 1 1 4 4 4 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_18 PF13238.6 CAV17618.1 - 0.0069 16.9 0.0 5.7 7.5 0.0 2.8 2 0 0 2 2 2 0 AAA domain AAA_33 PF13671.6 CAV17618.1 - 0.012 15.8 0.0 4.8 7.3 0.0 2.7 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.6 CAV17618.1 - 0.013 15.1 0.1 31 4.1 0.0 3.7 4 0 0 4 4 4 0 AAA domain Nuc_deoxyrib_tr PF05014.15 CAV17618.1 - 0.015 15.3 0.1 1.8 8.6 0.0 2.4 2 0 0 2 2 2 0 Nucleoside 2-deoxyribosyltransferase AAA_16 PF13191.6 CAV17618.1 - 0.019 15.4 0.4 11 6.3 0.0 3.4 2 2 0 2 2 2 0 AAA ATPase domain MMR_HSR1_Xtn PF16897.5 CAV17618.1 - 0.026 14.6 0.0 8.7 6.4 0.0 2.5 2 0 0 2 2 2 0 C-terminal region of MMR_HSR1 domain AAA_29 PF13555.6 CAV17618.1 - 0.043 13.6 0.0 13 5.6 0.0 2.6 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA_28 PF13521.6 CAV17618.1 - 0.057 13.7 0.0 13 6.0 0.0 2.7 2 0 0 2 2 2 0 AAA domain Ploopntkinase3 PF18751.1 CAV17618.1 - 0.095 12.6 0.0 1.9 8.4 0.0 2.5 2 1 0 2 2 2 0 P-loop Nucleotide Kinase3 KTI12 PF08433.10 CAV17618.1 - 0.097 12.1 0.0 2 7.8 0.0 2.2 2 0 0 2 2 2 0 Chromatin associated protein KTI12 DUF4350 PF14258.6 CAV17618.1 - 0.15 12.5 0.2 24 5.4 0.0 3.7 4 1 0 4 4 3 0 Domain of unknown function (DUF4350) NOG1 PF06858.14 CAV17618.1 - 1.1 9.0 3.1 1.7 8.5 0.4 2.7 3 1 0 3 3 3 0 Nucleolar GTP-binding protein 1 (NOG1) tRNA_SAD PF07973.14 CAV17619.1 - 0.00034 20.6 0.1 0.0013 18.8 0.0 1.9 2 0 0 2 2 2 1 Threonyl and Alanyl tRNA synthetase second additional domain GGDEF PF00990.21 CAV17620.1 - 3.9e-31 108.0 0.1 6.7e-31 107.2 0.1 1.4 1 0 0 1 1 1 1 Diguanylate cyclase, GGDEF domain GAF_2 PF13185.6 CAV17620.1 - 2.1e-15 57.2 0.0 4.5e-15 56.1 0.0 1.6 1 0 0 1 1 1 1 GAF domain GAF PF01590.26 CAV17620.1 - 9.4e-11 42.5 0.0 1.6e-10 41.8 0.0 1.4 1 0 0 1 1 1 1 GAF domain GAF_3 PF13492.6 CAV17620.1 - 0.016 15.5 0.0 0.072 13.4 0.0 2.0 1 1 0 1 1 1 0 GAF domain zinc-ribbons_6 PF07191.12 CAV17621.1 - 9.2e-26 89.6 12.2 1e-25 89.5 12.2 1.0 1 0 0 1 1 1 1 zinc-ribbons DNA_ligase_ZBD PF03119.16 CAV17621.1 - 0.0047 16.9 1.8 0.0047 16.9 1.8 2.9 3 0 0 3 3 3 1 NAD-dependent DNA ligase C4 zinc finger domain zf-RRPl_C4 PF17026.5 CAV17621.1 - 0.009 16.1 5.6 0.013 15.6 5.6 1.5 1 1 0 1 1 1 1 Putative ribonucleoprotein zinc-finger pf C4 type Zn-ribbon_8 PF09723.10 CAV17621.1 - 0.019 15.1 4.5 0.019 15.1 4.5 3.4 2 1 1 3 3 3 0 Zinc ribbon domain DZR PF12773.7 CAV17621.1 - 0.029 14.4 14.5 1.6 8.8 15.0 2.3 1 1 0 1 1 1 0 Double zinc ribbon DUF35_N PF12172.8 CAV17621.1 - 0.031 14.2 7.9 0.14 12.1 1.9 2.7 3 0 0 3 3 3 0 Rubredoxin-like zinc ribbon domain (DUF35_N) PhnA_Zn_Ribbon PF08274.12 CAV17621.1 - 0.086 12.8 14.4 0.98 9.4 0.7 3.4 2 1 0 2 2 2 0 PhnA Zinc-Ribbon zf-FPG_IleRS PF06827.14 CAV17621.1 - 0.16 11.8 7.9 3.1 7.7 0.1 3.4 2 1 1 3 3 3 0 Zinc finger found in FPG and IleRS zf-TFIIB PF13453.6 CAV17621.1 - 0.32 10.3 12.0 0.85 9.0 0.1 3.0 3 0 0 3 3 3 0 Transcription factor zinc-finger PolC_DP2 PF03833.13 CAV17621.1 - 0.33 8.7 7.3 0.33 8.8 7.3 1.0 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 DUF3624 PF12292.8 CAV17621.1 - 0.5 10.8 4.5 0.88 10.0 4.5 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3624) zf-ribbon_3 PF13248.6 CAV17621.1 - 0.97 8.9 0.1 0.97 8.9 0.1 3.8 3 1 1 4 4 4 0 zinc-ribbon domain zf-CCCH_6 PF18585.1 CAV17621.1 - 1.3 8.9 10.8 6.7 6.7 0.0 2.9 2 1 1 3 3 3 0 Chromatin remodeling factor Mit1 C-terminal Zn finger 2 TF_Zn_Ribbon PF08271.12 CAV17621.1 - 1.5 8.4 8.4 11 5.6 0.2 2.9 2 1 0 2 2 2 0 TFIIB zinc-binding DUF2797 PF10977.8 CAV17621.1 - 2.2 8.1 7.3 2.4 8.0 7.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2797) zf-C4_Topoisom PF01396.19 CAV17621.1 - 2.7 7.9 14.9 3.3 7.6 0.6 3.6 3 1 0 3 3 3 0 Topoisomerase DNA binding C4 zinc finger DiS_P_DiS PF06750.13 CAV17621.1 - 2.8 8.1 11.8 1.6 8.9 1.1 2.9 1 1 2 3 3 3 0 Bacterial Peptidase A24 N-terminal domain DUF1272 PF06906.11 CAV17621.1 - 5.1 7.3 11.5 3.7 7.7 2.6 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF1272) Zn_ribbon_SprT PF17283.2 CAV17621.1 - 8 6.5 10.7 9.4 6.2 0.0 3.5 2 1 1 3 3 3 0 SprT-like zinc ribbon domain zf-Dof PF02701.15 CAV17621.1 - 8.8 6.6 12.1 4.8 7.4 0.3 3.4 2 1 1 3 3 3 0 Dof domain, zinc finger Exonuc_VII_L PF02601.15 CAV17622.1 - 2.1e-98 329.7 6.2 2.6e-98 329.3 6.2 1.1 1 0 0 1 1 1 1 Exonuclease VII, large subunit tRNA_anti_2 PF13742.6 CAV17622.1 - 1.2e-30 105.6 0.0 2.8e-30 104.4 0.0 1.7 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA_anti-codon PF01336.25 CAV17622.1 - 3e-07 30.3 0.0 8e-07 29.0 0.0 1.8 2 0 0 2 2 2 1 OB-fold nucleic acid binding domain FixH PF05751.11 CAV17622.1 - 0.52 10.3 2.1 8.3 6.4 1.3 2.6 2 2 0 2 2 2 0 FixH SKA2 PF16740.5 CAV17622.1 - 0.98 9.2 17.0 5.5 6.8 0.6 2.5 1 1 1 2 2 2 0 Spindle and kinetochore-associated protein 2 IMPDH PF00478.25 CAV17623.1 - 2.8e-160 533.0 13.4 3.2e-160 532.8 13.4 1.0 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain CBS PF00571.28 CAV17623.1 - 1.6e-16 60.5 1.6 3.9e-09 36.8 0.1 3.4 2 1 1 3 3 3 2 CBS domain NMO PF03060.15 CAV17623.1 - 4.7e-12 45.9 13.9 9.3e-07 28.5 1.2 2.4 2 1 0 2 2 2 2 Nitronate monooxygenase TMP-TENI PF02581.17 CAV17623.1 - 0.00012 21.4 6.2 0.048 13.0 0.2 2.5 2 0 0 2 2 2 2 Thiamine monophosphate synthase FMN_dh PF01070.18 CAV17623.1 - 0.00016 20.8 12.5 0.00016 20.8 12.5 2.3 2 1 0 2 2 2 1 FMN-dependent dehydrogenase His_biosynth PF00977.21 CAV17623.1 - 0.00057 19.4 6.3 0.00083 18.9 4.5 2.2 2 1 0 2 2 2 1 Histidine biosynthesis protein DHO_dh PF01180.21 CAV17623.1 - 0.0024 17.1 2.0 0.0024 17.1 2.0 2.5 1 1 1 2 2 2 1 Dihydroorotate dehydrogenase Glu_synthase PF01645.17 CAV17623.1 - 0.0069 15.6 2.7 0.0069 15.6 2.7 2.1 2 0 0 2 2 2 1 Conserved region in glutamate synthase Radical_SAM PF04055.21 CAV17623.1 - 0.035 14.5 0.1 0.57 10.5 0.1 2.6 1 1 0 1 1 1 0 Radical SAM superfamily ThiG PF05690.14 CAV17623.1 - 0.037 13.3 12.8 0.054 12.8 5.6 3.1 4 0 0 4 4 4 0 Thiazole biosynthesis protein ThiG GMP_synt_C PF00958.22 CAV17624.1 - 1.2e-43 147.1 0.0 2.1e-43 146.3 0.0 1.4 1 0 0 1 1 1 1 GMP synthase C terminal domain GATase PF00117.28 CAV17624.1 - 1.2e-43 149.1 0.0 1.8e-43 148.6 0.0 1.2 1 0 0 1 1 1 1 Glutamine amidotransferase class-I NAD_synthase PF02540.17 CAV17624.1 - 7.9e-11 41.5 0.0 2.9e-08 33.1 0.1 2.2 2 0 0 2 2 2 2 NAD synthase Peptidase_C26 PF07722.13 CAV17624.1 - 3.4e-09 36.8 0.1 1.3e-08 34.9 0.0 2.0 1 1 1 2 2 2 1 Peptidase C26 Asn_synthase PF00733.21 CAV17624.1 - 0.00023 20.9 0.2 0.00039 20.2 0.2 1.3 1 0 0 1 1 1 1 Asparagine synthase tRNA_Me_trans PF03054.16 CAV17624.1 - 0.00078 18.3 0.0 0.0036 16.1 0.1 1.9 2 0 0 2 2 2 1 tRNA methyl transferase QueC PF06508.13 CAV17624.1 - 0.0022 17.6 0.0 0.3 10.5 0.0 2.3 2 0 0 2 2 2 2 Queuosine biosynthesis protein QueC PAPS_reduct PF01507.19 CAV17624.1 - 0.014 15.5 0.0 0.06 13.4 0.0 1.9 2 0 0 2 2 2 0 Phosphoadenosine phosphosulfate reductase family ATP_bind_3 PF01171.20 CAV17624.1 - 0.097 12.4 0.0 0.22 11.3 0.0 1.7 1 1 0 1 1 1 0 PP-loop family Glyco_hydro_19 PF00182.19 CAV17625.1 - 7.5e-32 111.1 2.7 1.7e-31 109.9 2.7 1.6 1 1 0 1 1 1 1 Chitinase class I CBM_5_12 PF02839.14 CAV17625.1 - 1.7e-05 25.1 8.8 1.7e-05 25.1 8.8 3.5 2 0 0 2 2 2 1 Carbohydrate binding domain GTP_EFTU_D4 PF14578.6 CAV17626.1 - 0.12 12.3 0.3 6.8 6.7 0.1 2.5 2 0 0 2 2 2 0 Elongation factor Tu domain 4 Gpr1_Fun34_YaaH PF01184.19 CAV17627.1 - 7.3e-36 123.7 21.0 8.7e-36 123.5 21.0 1.1 1 0 0 1 1 1 1 GPR1/FUN34/yaaH family DUF4305 PF14146.6 CAV17627.1 - 0.055 13.7 6.0 0.074 13.3 0.0 3.5 4 0 0 4 4 4 0 Domain of unknown function (DUF4305) Na_Ala_symp PF01235.17 CAV17628.1 - 3.2e-148 494.2 38.5 4e-148 493.9 38.5 1.0 1 0 0 1 1 1 1 Sodium:alanine symporter family Beta-Casp PF10996.8 CAV17629.1 - 1.8e-27 95.8 0.0 2.8e-27 95.2 0.0 1.3 1 0 0 1 1 1 1 Beta-Casp domain RMMBL PF07521.12 CAV17629.1 - 4.2e-14 52.2 0.0 8.5e-14 51.2 0.0 1.6 1 0 0 1 1 1 1 Zn-dependent metallo-hydrolase RNA specificity domain Lactamase_B PF00753.27 CAV17629.1 - 2.4e-11 44.0 0.2 4.9e-11 43.0 0.2 1.5 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_6 PF16661.5 CAV17629.1 - 1.9e-06 27.5 0.0 3.8e-06 26.5 0.0 1.5 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily domain Lactamase_B_2 PF12706.7 CAV17629.1 - 3.1e-06 26.8 0.0 6.4e-06 25.8 0.0 1.7 1 0 0 1 1 1 1 Beta-lactamase superfamily domain DUF1173 PF06666.11 CAV17629.1 - 0.0015 17.5 0.0 0.0022 17.0 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1173) Acyltransferase PF01553.21 CAV17630.1 - 7.4e-29 100.1 0.0 1.1e-28 99.6 0.0 1.2 1 0 0 1 1 1 1 Acyltransferase Rho_N PF07498.12 CAV17631.1 - 0.17 11.9 0.7 0.86 9.6 0.3 2.2 2 0 0 2 2 2 0 Rho termination factor, N-terminal domain Sulf_transp PF04143.14 CAV17632.1 - 3.8e-20 72.7 31.5 3.8e-13 49.7 11.8 2.1 1 1 1 2 2 2 2 Sulphur transport DUF4750 PF15938.5 CAV17632.1 - 2.3 8.0 12.2 0.34 10.6 1.4 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4750) DUF429 PF04250.13 CAV17633.1 - 5.9e-43 147.1 0.0 7.2e-43 146.8 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF429) Peptidase_M15_4 PF13539.6 CAV17634.1 - 1.8e-20 73.2 0.1 3.6e-20 72.2 0.1 1.5 1 0 0 1 1 1 1 D-alanyl-D-alanine carboxypeptidase VanY PF02557.17 CAV17634.1 - 0.029 14.2 0.0 0.057 13.2 0.0 1.5 1 0 0 1 1 1 0 D-alanyl-D-alanine carboxypeptidase Extensin-like_C PF06904.12 CAV17634.1 - 0.079 13.0 0.0 0.16 12.0 0.0 1.5 1 0 0 1 1 1 0 Extensin-like protein C-terminus Zn_protease PF05618.11 CAV17635.1 - 5.3e-49 165.6 2.0 3.2e-26 91.9 0.1 5.1 4 1 0 5 5 5 4 Putative ATP-dependant zinc protease gag-asp_proteas PF13975.6 CAV17635.1 - 1.9e-07 31.5 1.5 0.00074 20.0 0.1 4.6 4 2 0 4 4 4 2 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 CAV17635.1 - 0.011 16.4 2.3 0.79 10.4 0.0 4.1 4 3 1 5 5 5 0 Aspartyl protease RVP PF00077.20 CAV17635.1 - 0.13 12.5 0.0 2.9 8.3 0.0 2.7 2 0 0 2 2 2 0 Retroviral aspartyl protease zf-CCHC_4 PF14392.6 CAV17635.1 - 0.24 11.2 0.3 1.2 8.9 0.1 2.4 2 0 0 2 2 2 0 Zinc knuckle SmpB PF01668.18 CAV17636.1 - 3e-55 186.1 0.7 3.7e-55 185.7 0.7 1.1 1 0 0 1 1 1 1 SmpB protein Retro_M PF02813.14 CAV17636.1 - 0.053 13.9 0.0 0.093 13.1 0.0 1.4 1 0 0 1 1 1 0 Retroviral M domain Polyketide_cyc PF03364.20 CAV17637.1 - 9.9e-31 106.6 0.0 1.1e-30 106.5 0.0 1.0 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport Polyketide_cyc2 PF10604.9 CAV17637.1 - 2.1e-08 34.5 0.0 2.5e-08 34.3 0.0 1.0 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport COXG PF06240.13 CAV17637.1 - 0.054 13.2 0.0 0.12 12.1 0.0 1.5 2 0 0 2 2 2 0 Carbon monoxide dehydrogenase subunit G (CoxG) Ub-RnfH PF03658.14 CAV17638.1 - 1.7e-32 111.6 0.3 2.1e-32 111.3 0.3 1.1 1 0 0 1 1 1 1 RnfH family Ubiquitin UPF0058 PF01893.16 CAV17638.1 - 0.07 13.4 0.0 0.14 12.5 0.0 1.5 1 0 0 1 1 1 0 Uncharacterised protein family UPF0058 Phage_stabilise PF11134.8 CAV17638.1 - 0.075 11.9 0.0 0.083 11.7 0.0 1.1 1 0 0 1 1 1 0 Phage stabilisation protein Ub-Mut7C PF14451.6 CAV17638.1 - 0.077 12.8 0.1 0.15 11.9 0.1 1.5 1 1 0 1 1 1 0 Mut7-C ubiquitin TAF8_C PF10406.9 CAV17638.1 - 0.16 12.5 0.2 0.3 11.7 0.2 1.4 1 0 0 1 1 1 0 Transcription factor TFIID complex subunit 8 C-term SmpA_OmlA PF04355.13 CAV17639.1 - 6.5e-26 89.9 0.8 8.6e-26 89.5 0.8 1.2 1 0 0 1 1 1 1 SmpA / OmlA family PAS_11 PF14598.6 CAV17639.1 - 0.017 15.2 0.1 0.048 13.8 0.1 1.8 1 1 0 1 1 1 0 PAS domain SMC_N PF02463.19 CAV17640.1 - 1.5e-18 67.0 0.0 1.7e-17 63.6 0.0 2.4 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 CAV17640.1 - 2e-12 48.1 24.9 5.1e-11 43.4 20.6 3.0 2 1 0 2 2 2 1 AAA domain AAA_15 PF13175.6 CAV17640.1 - 7.6e-08 32.4 1.4 2.7e-07 30.7 1.4 2.0 1 1 0 1 1 1 1 AAA ATPase domain AAA_29 PF13555.6 CAV17640.1 - 1.3e-05 24.9 0.2 2.9e-05 23.7 0.2 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_21 PF13304.6 CAV17640.1 - 0.0098 15.7 0.3 1.5 8.6 0.0 2.8 3 0 0 3 3 3 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_22 PF13401.6 CAV17640.1 - 0.13 12.5 0.2 0.13 12.5 0.2 3.3 3 1 0 3 3 3 0 AAA domain NAPRTase_N PF17767.1 CAV17640.1 - 0.36 11.2 5.7 7.9 6.9 0.9 2.7 2 0 0 2 2 2 0 Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain ABC_tran PF00005.27 CAV17640.1 - 0.46 11.0 14.6 5.7 7.5 6.2 3.9 2 2 0 2 2 2 0 ABC transporter RsgA_GTPase PF03193.16 CAV17640.1 - 0.79 9.6 5.6 0.47 10.3 0.2 3.0 3 1 1 4 4 4 0 RsgA GTPase EDR1 PF14381.6 CAV17640.1 - 3.5 7.3 5.8 2.3 7.9 1.1 2.5 2 1 0 2 2 2 0 Ethylene-responsive protein kinase Le-CTR1 ING PF12998.7 CAV17640.1 - 5.7 7.6 20.2 0.15 12.7 4.3 3.6 3 1 1 4 4 4 0 Inhibitor of growth proteins N-terminal histone-binding DUF2935 PF11155.8 CAV17640.1 - 9.2 6.6 10.8 1.6 9.1 3.5 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF2935) NAD_kinase PF01513.21 CAV17642.1 - 1.2e-71 241.3 0.0 5.1e-71 239.2 0.0 1.7 1 1 0 1 1 1 1 ATP-NAD kinase GrpE PF01025.19 CAV17643.1 - 5.7e-54 182.2 10.0 5.7e-54 182.2 10.0 1.6 1 1 1 2 2 2 1 GrpE IZUMO PF15005.6 CAV17643.1 - 0.0023 18.5 1.3 0.0034 17.9 1.1 1.4 1 1 0 1 1 1 1 Izumo sperm-egg fusion, Ig domain-associated ADIP PF11559.8 CAV17643.1 - 0.057 13.5 11.6 0.084 13.0 11.6 1.2 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding SDF PF00375.18 CAV17644.1 - 3.8e-115 385.0 44.6 4.3e-115 384.9 44.6 1.0 1 0 0 1 1 1 1 Sodium:dicarboxylate symporter family HSP70 PF00012.20 CAV17645.1 - 1.3e-259 862.5 22.7 1.5e-259 862.3 22.7 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 CAV17645.1 - 3.2e-11 42.6 1.0 3.2e-11 42.6 1.0 3.1 3 2 0 3 3 3 2 MreB/Mbl protein RNA_pol_Rpb1_6 PF04992.14 CAV17645.1 - 0.12 12.2 4.6 0.15 11.8 2.7 2.1 1 1 1 2 2 2 0 RNA polymerase Rpb1, domain 6 Lant_dehydr_C PF14028.6 CAV17645.1 - 0.2 11.1 1.5 0.37 10.3 1.5 1.4 1 0 0 1 1 1 0 Lantibiotic biosynthesis dehydratase C-term cwf21 PF08312.12 CAV17645.1 - 0.24 11.6 1.3 16 5.8 0.0 2.8 2 0 0 2 2 2 0 cwf21 domain OsmC PF02566.19 CAV17645.1 - 1.3 9.5 0.0 1.3 9.5 0.0 3.4 4 0 0 4 4 4 0 OsmC-like protein DnaJ_C PF01556.18 CAV17646.1 - 3.8e-46 156.9 0.1 5.2e-46 156.4 0.1 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 CAV17646.1 - 5.5e-26 90.5 1.8 8.4e-26 89.9 1.8 1.3 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.19 CAV17646.1 - 9.5e-15 54.7 19.1 2.2e-14 53.5 19.1 1.7 1 0 0 1 1 1 1 DnaJ central domain Anti-TRAP PF15777.5 CAV17646.1 - 0.0038 17.2 17.6 0.049 13.6 4.1 3.0 1 1 1 2 2 2 2 Tryptophan RNA-binding attenuator protein inhibitory protein DUF3484 PF11983.8 CAV17646.1 - 0.081 14.0 0.0 0.23 12.6 0.0 1.8 1 0 0 1 1 1 0 Membrane-attachment and polymerisation-promoting switch Cytochrome_C7 PF14522.6 CAV17646.1 - 0.084 12.9 10.4 5.6 7.0 10.6 2.6 1 1 1 2 2 2 0 Cytochrome c7 and related cytochrome c RseC_MucC PF04246.12 CAV17646.1 - 3 7.8 5.3 0.46 10.5 1.0 1.8 1 1 1 2 2 2 0 Positive regulator of sigma(E), RseC/MucC Cytochrom_c3_2 PF14537.6 CAV17646.1 - 4.5 7.8 11.1 28 5.3 8.0 2.5 1 1 0 1 1 1 0 Cytochrome c3 ComP_DUS PF16732.5 CAV17647.1 - 1.3e-15 58.0 0.5 1.8e-15 57.6 0.5 1.2 1 0 0 1 1 1 1 Type IV minor pilin ComP, DNA uptake sequence receptor N_methyl PF07963.12 CAV17647.1 - 2.3e-07 30.1 4.3 4e-07 29.3 4.3 1.3 1 0 0 1 1 1 1 Prokaryotic N-terminal methylation motif MitoNEET_N PF10660.9 CAV17647.1 - 0.023 14.7 0.1 0.04 13.9 0.1 1.4 1 0 0 1 1 1 0 Iron-containing outer mitochondrial membrane protein N-terminus CcmF_C PF16327.5 CAV17647.1 - 0.028 13.7 0.1 0.03 13.6 0.1 1.1 1 0 0 1 1 1 0 Cytochrome c-type biogenesis protein CcmF C-terminal DUF4552 PF15089.6 CAV17647.1 - 0.081 12.0 0.1 0.11 11.6 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4552) GspH PF12019.8 CAV17648.1 - 4.7e-09 36.6 0.0 7.6e-09 36.0 0.0 1.4 1 1 0 1 1 1 1 Type II transport protein GspH N_methyl PF07963.12 CAV17648.1 - 1.3e-06 27.7 4.5 2e-06 27.1 4.5 1.3 1 0 0 1 1 1 1 Prokaryotic N-terminal methylation motif N_methyl PF07963.12 CAV17649.1 - 0.00022 20.6 2.0 0.00056 19.3 2.0 1.8 1 0 0 1 1 1 1 Prokaryotic N-terminal methylation motif N_methyl PF07963.12 CAV17651.1 - 7.1e-07 28.5 0.8 1.4e-06 27.6 0.8 1.5 1 0 0 1 1 1 1 Prokaryotic N-terminal methylation motif Rotavirus_VP1 PF12289.8 CAV17652.1 - 0.059 12.4 0.3 0.063 12.3 0.3 1.0 1 0 0 1 1 1 0 Rotavirus VP1 C-terminal domain ABG_transport PF03806.13 CAV17653.1 - 1.7e-210 699.5 33.7 1.9e-210 699.3 33.7 1.0 1 0 0 1 1 1 1 AbgT putative transporter family DcuC PF03606.15 CAV17653.1 - 1.4e-06 27.1 27.1 2e-06 26.6 26.1 1.7 1 1 0 1 1 1 1 C4-dicarboxylate anaerobic carrier TMEM100 PF16311.5 CAV17653.1 - 5.2 6.7 5.4 6.5 6.4 0.9 2.7 2 0 0 2 2 2 0 Transmembrane protein 100 DUF21 PF01595.20 CAV17654.1 - 5.2e-44 150.0 3.2 7.9e-44 149.5 3.2 1.2 1 0 0 1 1 1 1 Cyclin M transmembrane N-terminal domain CorC_HlyC PF03471.17 CAV17654.1 - 1.4e-17 63.5 0.1 2.9e-17 62.4 0.1 1.6 1 0 0 1 1 1 1 Transporter associated domain CBS PF00571.28 CAV17654.1 - 2.6e-10 40.6 0.0 5.7e-05 23.5 0.0 2.6 2 0 0 2 2 2 2 CBS domain MafB19-deam PF14437.6 CAV17655.1 - 1.3e-31 109.2 0.0 1.8e-31 108.7 0.0 1.2 1 0 0 1 1 1 1 MafB19-like deaminase dCMP_cyt_deam_1 PF00383.23 CAV17655.1 - 2e-28 98.2 0.0 3.1e-28 97.6 0.0 1.3 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region Bd3614-deam PF14439.6 CAV17655.1 - 2.1e-05 24.6 0.1 0.00036 20.6 0.1 2.2 1 1 0 1 1 1 1 Bd3614-like deaminase SNAD4 PF18750.1 CAV17655.1 - 4.2e-05 23.6 0.1 0.00015 21.9 0.0 1.8 2 0 0 2 2 2 1 Secreted Novel AID/APOBEC-like Deaminase 4 APOBEC3 PF18771.1 CAV17655.1 - 0.00044 20.4 0.0 0.001 19.2 0.0 1.5 1 0 0 1 1 1 1 APOBEC3 NAD2 PF18782.1 CAV17655.1 - 0.00071 19.7 0.0 0.0014 18.8 0.0 1.5 1 0 0 1 1 1 1 Novel AID APOBEC clade 2 TAF4 PF05236.14 CAV17655.1 - 0.001 18.9 0.3 0.001 18.9 0.3 1.1 1 0 0 1 1 1 1 Transcription initiation factor TFIID component TAF4 family APOBEC2 PF18772.1 CAV17655.1 - 0.0012 18.9 0.0 0.0023 18.0 0.0 1.5 1 0 0 1 1 1 1 APOBEC2 APOBEC_N PF08210.11 CAV17655.1 - 0.0072 16.2 0.1 0.015 15.2 0.1 1.7 1 1 0 1 1 1 1 APOBEC-like N-terminal domain NAD1 PF18778.1 CAV17655.1 - 0.018 15.1 0.0 0.04 14.0 0.0 1.5 1 0 0 1 1 1 0 Novel AID APOBEC clade 1 DUF3744 PF12558.8 CAV17655.1 - 0.074 13.8 0.2 0.17 12.6 0.2 1.7 1 1 0 1 1 1 0 ATP-binding cassette cobalt transporter Inv-AAD PF18785.1 CAV17655.1 - 0.087 12.7 0.1 0.22 11.4 0.1 1.6 1 1 0 1 1 1 0 Invertebrate-AID/APOBEC-deaminase Snurportin1 PF11538.8 CAV17656.1 - 0.95 9.7 5.8 1.3 9.3 1.4 2.1 1 1 1 2 2 2 0 Snurportin1 SBP_bac_3 PF00497.20 CAV17657.1 - 5.1e-27 94.8 0.1 8.3e-27 94.1 0.1 1.4 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 SLT PF01464.20 CAV17657.1 - 2.6e-20 72.2 0.0 6.8e-20 70.9 0.0 1.6 1 0 0 1 1 1 1 Transglycosylase SLT domain Lysozyme_like PF13702.6 CAV17657.1 - 0.0086 15.8 0.0 0.024 14.3 0.0 1.7 1 1 0 1 1 1 1 Lysozyme-like LPAM_1 PF08139.12 CAV17657.1 - 0.22 12.1 2.3 0.47 11.0 2.3 1.6 1 0 0 1 1 1 0 Prokaryotic membrane lipoprotein lipid attachment site GATase_5 PF13507.6 CAV17658.1 - 1.3e-106 355.4 0.4 2e-106 354.9 0.4 1.3 1 0 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain AIRS_C PF02769.22 CAV17658.1 - 1.5e-45 155.1 2.9 7e-27 94.5 0.0 2.8 3 0 0 3 3 3 2 AIR synthase related protein, C-terminal domain FGAR-AT_N PF18076.1 CAV17658.1 - 4.3e-40 136.3 0.0 7.7e-40 135.5 0.0 1.4 1 0 0 1 1 1 1 Formylglycinamide ribonucleotide amidotransferase N-terminal FGAR-AT_linker PF18072.1 CAV17658.1 - 2.4e-23 82.4 1.4 6e-23 81.1 0.1 2.5 3 0 0 3 3 3 1 Formylglycinamide ribonucleotide amidotransferase linker domain DUF3332 PF11810.8 CAV17659.1 - 1.2e-38 132.4 0.1 1.4e-38 132.2 0.1 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF3332) Laminin_G_3 PF13385.6 CAV17659.1 - 0.089 12.9 0.0 0.11 12.6 0.0 1.3 1 0 0 1 1 1 0 Concanavalin A-like lectin/glucanases superfamily THDPS_M PF14789.6 CAV17660.1 - 1.4e-16 60.2 0.0 3.1e-16 59.2 0.0 1.6 1 0 0 1 1 1 1 Tetrahydrodipicolinate N-succinyltransferase middle Hexapep_2 PF14602.6 CAV17660.1 - 8.4e-13 47.8 0.3 8.4e-13 47.8 0.3 3.2 3 0 0 3 3 3 1 Hexapeptide repeat of succinyl-transferase THDPS_N PF14790.6 CAV17660.1 - 0.00023 21.0 0.0 0.00036 20.4 0.0 1.3 1 0 0 1 1 1 1 Tetrahydrodipicolinate N-succinyltransferase N-terminal Hexapep PF00132.24 CAV17660.1 - 0.00071 19.2 7.9 0.39 10.5 0.1 4.1 3 1 0 3 3 3 2 Bacterial transferase hexapeptide (six repeats) MarC PF01914.17 CAV17661.1 - 1.5e-51 174.7 14.1 1.8e-51 174.5 14.1 1.0 1 0 0 1 1 1 1 MarC family integral membrane protein DUF2518 PF10726.9 CAV17661.1 - 0.64 9.7 6.7 0.19 11.4 0.4 2.2 2 0 0 2 2 2 0 Protein of function (DUF2518) GGGtGRT PF14057.6 CAV17662.1 - 1.5e-176 586.1 3.4 1.8e-176 585.9 3.4 1.0 1 0 0 1 1 1 1 GGGtGRT protein ETC_C1_NDUFA4 PF04800.12 CAV17662.1 - 0.18 12.1 0.1 0.39 11.0 0.1 1.5 1 0 0 1 1 1 0 ETC complex I subunit conserved region NifU_N PF01592.16 CAV17663.1 - 0.00012 22.2 0.3 0.00021 21.4 0.1 1.7 2 0 0 2 2 2 1 NifU-like N terminal domain YebG PF07130.12 CAV17664.1 - 4.7e-32 109.7 5.2 4.7e-32 109.7 5.2 1.5 1 1 1 2 2 2 1 YebG protein Rhomboid_SP PF12595.8 CAV17664.1 - 0.099 12.0 0.2 0.12 11.7 0.2 1.1 1 0 0 1 1 1 0 Rhomboid serine protease LysR_substrate PF03466.20 CAV17665.1 - 1.7e-42 145.2 0.0 2.1e-42 144.9 0.0 1.1 1 0 0 1 1 1 1 LysR substrate binding domain HTH_1 PF00126.27 CAV17665.1 - 1.6e-15 56.8 0.3 3e-15 55.9 0.3 1.5 1 0 0 1 1 1 1 Bacterial regulatory helix-turn-helix protein, lysR family PBP_like PF12727.7 CAV17665.1 - 4.3e-06 26.0 0.0 5.6e-06 25.6 0.0 1.2 1 0 0 1 1 1 1 PBP superfamily domain SLAC1 PF03595.17 CAV17666.1 - 9.1e-30 104.0 38.7 1.2e-29 103.7 38.7 1.1 1 0 0 1 1 1 1 Voltage-dependent anion channel AC_N PF16214.5 CAV17666.1 - 6.8 5.7 6.2 12 4.8 6.2 1.4 1 0 0 1 1 1 0 Adenylyl cyclase N-terminal extracellular and transmembrane region Exonuc_V_gamma PF04257.14 CAV17667.1 - 7.6e-300 996.6 3.3 8.8e-300 996.4 3.3 1.0 1 0 0 1 1 1 1 Exodeoxyribonuclease V, gamma subunit RecC_C PF17946.1 CAV17667.1 - 2e-56 190.9 1.0 5.5e-56 189.5 0.2 2.0 2 0 0 2 2 2 1 RecC C-terminal domain UvrD-helicase PF00580.21 CAV17669.1 - 2.2e-59 201.5 0.0 5.7e-59 200.2 0.0 1.7 1 0 0 1 1 1 1 UvrD/REP helicase N-terminal domain UvrD_C PF13361.6 CAV17669.1 - 1.6e-20 73.8 0.0 4.8e-18 65.7 0.0 2.7 1 1 0 1 1 1 1 UvrD-like helicase C-terminal domain AAA_19 PF13245.6 CAV17669.1 - 3.3e-18 66.4 0.0 1.7e-17 64.1 0.0 2.3 1 1 0 1 1 1 1 AAA domain UvrD_C_2 PF13538.6 CAV17669.1 - 3.3e-08 33.2 0.0 0.00034 20.4 0.0 2.8 2 0 0 2 2 2 2 UvrD-like helicase C-terminal domain PDDEXK_1 PF12705.7 CAV17669.1 - 3.2e-07 30.5 0.3 1.1e-06 28.8 0.3 1.9 1 0 0 1 1 1 1 PD-(D/E)XK nuclease superfamily AAA_11 PF13086.6 CAV17669.1 - 0.0035 17.2 0.0 0.008 16.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain DUF2075 PF09848.9 CAV17669.1 - 0.0041 16.4 0.0 0.025 13.9 0.0 2.2 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) AAA_12 PF13087.6 CAV17669.1 - 0.0046 16.6 0.0 0.018 14.7 0.0 1.9 2 0 0 2 2 2 1 AAA domain AAA_25 PF13481.6 CAV17669.1 - 0.079 12.5 0.1 0.22 11.1 0.1 1.8 1 0 0 1 1 1 0 AAA domain Invasin_D3 PF09134.10 CAV17669.1 - 0.088 13.1 0.0 0.28 11.5 0.0 1.8 1 0 0 1 1 1 0 Invasin, domain 3 ResIII PF04851.15 CAV17669.1 - 0.13 12.3 0.0 0.34 10.9 0.0 1.7 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit TFIIE_beta PF02186.15 CAV17669.1 - 0.2 11.9 0.8 1.1 9.6 0.0 2.6 3 0 0 3 3 3 0 TFIIE beta subunit core domain AAA_30 PF13604.6 CAV17669.1 - 0.34 10.6 2.3 0.69 9.6 0.1 2.6 3 1 0 4 4 4 0 AAA domain AAA_30 PF13604.6 CAV17670.1 - 1.7e-31 109.4 0.1 3.2e-30 105.3 0.1 2.4 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.6 CAV17670.1 - 3.9e-29 101.9 0.5 1.4e-28 100.1 0.1 2.1 3 0 0 3 3 2 1 AAA domain UvrD_C_2 PF13538.6 CAV17670.1 - 1.8e-14 53.3 0.0 3.9e-14 52.2 0.0 1.6 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain Helicase_RecD PF05127.14 CAV17670.1 - 2.6e-13 50.2 0.2 6.9e-13 48.8 0.0 1.8 2 0 0 2 2 2 1 Helicase AAA_11 PF13086.6 CAV17670.1 - 8.7e-11 42.1 0.2 4.2e-06 26.7 0.1 2.5 2 0 0 2 2 2 2 AAA domain Viral_helicase1 PF01443.18 CAV17670.1 - 1.3e-09 38.2 1.7 0.014 15.1 0.0 3.6 3 1 0 3 3 3 2 Viral (Superfamily 1) RNA helicase SH3_13 PF18335.1 CAV17670.1 - 7.3e-08 32.1 0.0 1.5e-07 31.1 0.0 1.6 1 0 0 1 1 1 1 ATP-dependent RecD-like DNA helicase SH3 domain AAA_22 PF13401.6 CAV17670.1 - 9.3e-07 29.2 0.1 7.1e-06 26.3 0.0 2.4 2 0 0 2 2 2 1 AAA domain DUF2075 PF09848.9 CAV17670.1 - 1.5e-06 27.7 0.0 0.0013 18.0 0.0 3.0 3 0 0 3 3 3 2 Uncharacterized conserved protein (DUF2075) UvrD-helicase PF00580.21 CAV17670.1 - 0.00011 21.9 0.4 0.00011 21.9 0.4 2.4 2 1 1 3 3 3 1 UvrD/REP helicase N-terminal domain UvrD_C PF13361.6 CAV17670.1 - 0.00012 21.7 0.3 0.00044 19.7 0.0 2.0 2 1 0 2 2 2 1 UvrD-like helicase C-terminal domain AAA_16 PF13191.6 CAV17670.1 - 0.002 18.5 1.5 0.0079 16.6 0.0 2.5 2 1 0 2 2 2 1 AAA ATPase domain AAA_28 PF13521.6 CAV17670.1 - 0.0075 16.5 0.5 0.022 15.0 0.5 1.8 1 0 0 1 1 1 1 AAA domain T2SSE PF00437.20 CAV17670.1 - 0.02 14.0 0.0 0.032 13.3 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein PhoH PF02562.16 CAV17670.1 - 0.024 14.1 0.1 0.095 12.1 0.1 2.0 1 1 0 1 1 1 0 PhoH-like protein TrwB_AAD_bind PF10412.9 CAV17670.1 - 0.032 13.1 0.1 0.071 12.0 0.1 1.5 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain CbiA PF01656.23 CAV17670.1 - 0.061 13.4 0.6 0.23 11.5 0.6 2.0 1 0 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain AAA PF00004.29 CAV17670.1 - 0.088 13.2 0.3 0.31 11.4 0.3 2.0 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) DUF87 PF01935.17 CAV17670.1 - 0.095 12.8 1.1 0.46 10.6 0.1 2.3 3 0 0 3 3 2 0 Helicase HerA, central domain AAA_7 PF12775.7 CAV17670.1 - 0.11 12.0 0.1 0.25 10.8 0.1 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region NTPase_1 PF03266.15 CAV17670.1 - 0.12 12.3 0.7 0.35 10.8 0.7 1.7 1 0 0 1 1 1 0 NTPase RNA_helicase PF00910.22 CAV17670.1 - 0.2 12.1 0.1 0.56 10.6 0.1 1.8 1 0 0 1 1 1 0 RNA helicase L_lactis_RepB_C PF06430.12 CAV17671.1 - 0.097 12.7 0.0 0.097 12.7 0.0 1.1 1 0 0 1 1 1 0 Lactococcus lactis RepB C-terminus AA_kinase PF00696.28 CAV17672.1 - 1.2e-26 93.8 0.1 1.6e-26 93.4 0.1 1.2 1 0 0 1 1 1 1 Amino acid kinase family Acetyltransf_1 PF00583.25 CAV17672.1 - 9.2e-08 32.3 0.1 6.4e-07 29.6 0.0 2.2 1 1 1 2 2 2 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 CAV17672.1 - 5.3e-06 26.8 0.0 1.6e-05 25.3 0.0 1.8 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 CAV17672.1 - 0.0006 19.7 0.0 0.002 18.1 0.0 1.8 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain DUF2850 PF11012.8 CAV17673.1 - 1.1e-32 112.2 0.4 1.5e-32 111.7 0.4 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2850) MltA PF03562.17 CAV17674.1 - 1.1e-39 136.6 0.1 2.4e-37 128.9 0.1 2.2 1 1 0 1 1 1 1 MltA specific insert domain 3D PF06725.11 CAV17674.1 - 1.9e-20 72.8 0.0 4.5e-20 71.6 0.0 1.7 1 0 0 1 1 1 1 3D domain ThiF PF00899.21 CAV17675.1 - 1.1e-37 129.8 0.4 1.2e-37 129.6 0.4 1.1 1 0 0 1 1 1 1 ThiF family Sacchrp_dh_NADP PF03435.18 CAV17675.1 - 6e-06 26.5 0.8 4.7e-05 23.7 0.8 2.2 1 1 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain NAD_binding_7 PF13241.6 CAV17675.1 - 0.00044 20.6 1.9 0.0019 18.6 0.6 2.3 2 1 0 2 2 2 1 Putative NAD(P)-binding UDPG_MGDP_dh_N PF03721.14 CAV17675.1 - 0.0026 17.4 0.5 0.0046 16.6 0.5 1.4 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain AlaDh_PNT_C PF01262.21 CAV17675.1 - 0.012 14.9 0.0 0.016 14.5 0.0 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain 3HCDH_N PF02737.18 CAV17675.1 - 0.073 12.9 0.0 0.12 12.2 0.0 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Cons_hypoth95 PF03602.15 CAV17675.1 - 0.11 12.2 0.0 0.2 11.3 0.0 1.5 1 0 0 1 1 1 0 Conserved hypothetical protein 95 SufE PF02657.15 CAV17676.1 - 8.4e-45 151.6 0.0 9.5e-45 151.4 0.0 1.0 1 0 0 1 1 1 1 Fe-S metabolism associated domain TMEM37 PF15108.6 CAV17676.1 - 0.13 12.1 0.1 0.18 11.6 0.1 1.2 1 0 0 1 1 1 0 Voltage-dependent calcium channel gamma-like subunit protein family Aminotran_5 PF00266.19 CAV17677.1 - 2.9e-150 500.3 2.1 3.3e-150 500.2 2.1 1.0 1 0 0 1 1 1 1 Aminotransferase class-V Cys_Met_Meta_PP PF01053.20 CAV17677.1 - 1.1e-06 27.4 0.9 2.2e-06 26.5 0.4 1.7 2 0 0 2 2 2 1 Cys/Met metabolism PLP-dependent enzyme Beta_elim_lyase PF01212.21 CAV17677.1 - 0.00046 19.6 0.2 0.0006 19.2 0.2 1.3 1 0 0 1 1 1 1 Beta-eliminating lyase GDC-P PF02347.16 CAV17677.1 - 0.00074 18.4 0.1 0.0013 17.7 0.1 1.3 1 0 0 1 1 1 1 Glycine cleavage system P-protein ApbA_C PF08546.11 CAV17678.1 - 4.8e-33 114.0 0.2 7.6e-33 113.4 0.2 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA C terminal ApbA PF02558.16 CAV17678.1 - 2.1e-30 105.4 0.2 5.4e-30 104.1 0.2 1.6 1 1 0 1 1 1 1 Ketopantoate reductase PanE/ApbA F420_oxidored PF03807.17 CAV17678.1 - 5.2e-06 26.9 0.0 1.2e-05 25.8 0.0 1.7 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent NAD_binding_2 PF03446.15 CAV17678.1 - 6.4e-06 26.4 0.0 1.3e-05 25.4 0.0 1.5 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_Gly3P_dh_N PF01210.23 CAV17678.1 - 2.7e-05 24.2 0.4 0.00085 19.3 0.4 2.5 1 1 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus 3HCDH_N PF02737.18 CAV17678.1 - 0.0032 17.4 0.6 0.011 15.6 0.0 2.2 3 0 0 3 3 3 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Glyco_trans_4_2 PF13477.6 CAV17678.1 - 0.01 15.8 0.0 0.022 14.8 0.0 1.5 1 0 0 1 1 1 0 Glycosyl transferase 4-like Shikimate_DH PF01488.20 CAV17678.1 - 0.043 13.9 0.1 0.35 10.9 0.0 2.1 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase 2-Hacid_dh_C PF02826.19 CAV17678.1 - 0.048 13.0 0.1 0.15 11.4 0.0 1.9 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_binding_7 PF13241.6 CAV17678.1 - 0.076 13.5 0.0 0.22 12.0 0.0 1.9 2 0 0 2 2 2 0 Putative NAD(P)-binding Channel_Tsx PF03502.13 CAV17679.1 - 7.6e-91 304.2 23.0 8.8e-91 304.0 23.0 1.0 1 0 0 1 1 1 1 Nucleoside-specific channel-forming protein, Tsx DUF4397 PF14344.6 CAV17681.1 - 1.3e-50 171.2 22.1 8.6e-18 65.3 0.9 4.1 2 2 2 4 4 4 4 Domain of unknown function (DUF4397) PapC_N PF13954.6 CAV17681.1 - 0.039 14.0 0.3 2.2 8.3 0.0 3.3 4 1 1 5 5 5 0 PapC N-terminal domain MFS_1 PF07690.16 CAV17682.1 - 3.8e-18 65.5 69.6 5.5e-17 61.7 41.3 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Acatn PF13000.7 CAV17682.1 - 2.9e-07 29.4 15.1 0.00019 20.1 2.0 3.3 2 1 0 2 2 2 2 Acetyl-coenzyme A transporter 1 Pro_isomerase PF00160.21 CAV17683.1 - 9.9e-43 146.1 0.6 1.1e-42 146.0 0.6 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Lipoprotein_16 PF03923.13 CAV17684.1 - 1e-51 174.7 6.6 1.2e-51 174.5 6.6 1.0 1 0 0 1 1 1 1 Uncharacterized lipoprotein DUF4136 PF13590.6 CAV17684.1 - 0.0018 18.8 0.4 0.0033 18.0 0.4 1.5 1 1 0 1 1 1 1 Domain of unknown function (DUF4136) LPAM_1 PF08139.12 CAV17684.1 - 0.18 12.3 4.0 0.48 11.0 4.0 1.8 1 1 0 1 1 1 0 Prokaryotic membrane lipoprotein lipid attachment site MTS PF05175.14 CAV17685.1 - 3.2e-54 183.0 0.1 1.7e-51 174.2 0.0 2.1 2 0 0 2 2 2 2 Methyltransferase small domain PrmA PF06325.13 CAV17685.1 - 2.4e-10 40.3 0.0 5.1e-10 39.2 0.0 1.5 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_31 PF13847.6 CAV17685.1 - 5.1e-10 39.4 1.3 8e-10 38.7 0.2 1.9 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 CAV17685.1 - 6.2e-10 39.7 0.1 2.3e-09 37.8 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 CAV17685.1 - 1e-07 32.6 0.1 1.8e-05 25.4 0.0 2.4 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 CAV17685.1 - 9.2e-07 29.4 0.0 2.4e-06 28.1 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain MTS_N PF08468.11 CAV17685.1 - 3.2e-06 27.3 0.5 1e-05 25.6 0.0 2.0 2 1 1 3 3 3 1 Methyltransferase small domain N-terminal Cons_hypoth95 PF03602.15 CAV17685.1 - 0.00053 19.7 0.0 0.00099 18.8 0.0 1.4 1 0 0 1 1 1 1 Conserved hypothetical protein 95 Methyltransf_2 PF00891.18 CAV17685.1 - 0.0011 18.3 0.0 0.048 13.0 0.0 2.4 2 1 0 2 2 2 1 O-methyltransferase domain Methyltransf_4 PF02390.17 CAV17685.1 - 0.0016 18.0 0.2 0.0057 16.1 0.1 2.1 2 1 0 2 2 2 1 Putative methyltransferase Methyltransf_23 PF13489.6 CAV17685.1 - 0.0024 17.7 0.0 0.015 15.2 0.0 2.3 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_10 PF05971.12 CAV17685.1 - 0.003 17.0 0.1 0.0064 15.9 0.0 1.6 2 0 0 2 2 2 1 RNA methyltransferase Methyltransf_18 PF12847.7 CAV17685.1 - 0.0034 17.3 0.0 0.0067 16.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_32 PF13679.6 CAV17685.1 - 0.0043 17.0 0.0 0.013 15.5 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain UPF0020 PF01170.18 CAV17685.1 - 0.03 14.0 0.0 0.053 13.2 0.0 1.4 1 0 0 1 1 1 0 Putative RNA methylase family UPF0020 Methyltransf_16 PF10294.9 CAV17685.1 - 0.077 12.7 0.0 0.16 11.7 0.0 1.5 1 0 0 1 1 1 0 Lysine methyltransferase BolA PF01722.18 CAV17686.1 - 1.3e-31 108.7 0.8 1.5e-31 108.5 0.8 1.1 1 0 0 1 1 1 1 BolA-like protein DUF5454 PF17535.2 CAV17686.1 - 0.012 15.0 0.0 0.013 14.9 0.0 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5454) NQRA PF05896.11 CAV17687.1 - 1.7e-113 378.3 0.1 2.1e-113 378.0 0.1 1.1 1 0 0 1 1 1 1 Na(+)-translocating NADH-quinone reductase subunit A (NQRA) NQRA_SLBB PF11973.8 CAV17687.1 - 1.3e-21 76.9 0.5 4.1e-21 75.4 0.5 1.9 1 0 0 1 1 1 1 NQRA C-terminal domain RnfC_N PF13375.6 CAV17687.1 - 0.00033 20.6 0.3 0.00061 19.7 0.3 1.4 1 0 0 1 1 1 1 RnfC Barrel sandwich hybrid domain Biotin_lipoyl_2 PF13533.6 CAV17687.1 - 0.1 12.5 0.1 0.4 10.6 0.0 2.0 2 0 0 2 2 2 0 Biotin-lipoyl like Biotin_lipoyl PF00364.22 CAV17687.1 - 0.12 12.2 0.2 0.25 11.2 0.2 1.5 1 0 0 1 1 1 0 Biotin-requiring enzyme NQR2_RnfD_RnfE PF03116.15 CAV17688.1 - 4.7e-108 361.0 27.5 5.4e-108 360.8 27.5 1.0 1 0 0 1 1 1 1 NQR2, RnfD, RnfE family FMN_bind PF04205.14 CAV17689.1 - 9.2e-15 55.0 0.0 1.8e-14 54.1 0.0 1.5 1 0 0 1 1 1 1 FMN-binding domain Rnf-Nqr PF02508.14 CAV17690.1 - 9.8e-63 211.3 13.4 1.1e-62 211.1 13.4 1.0 1 0 0 1 1 1 1 Rnf-Nqr subunit, membrane protein DUF3955 PF13127.6 CAV17690.1 - 0.88 9.4 0.0 0.88 9.4 0.0 3.7 5 0 0 5 5 5 0 Protein of unknown function (DUF3955) Rnf-Nqr PF02508.14 CAV17691.1 - 2.1e-59 200.4 16.8 2.3e-59 200.3 16.8 1.0 1 0 0 1 1 1 1 Rnf-Nqr subunit, membrane protein NAD_binding_1 PF00175.21 CAV17692.1 - 4.1e-17 62.8 0.0 7e-17 62.0 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain Fer2 PF00111.27 CAV17692.1 - 9.7e-11 41.5 0.3 1.7e-10 40.7 0.3 1.4 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain FAD_binding_6 PF00970.24 CAV17692.1 - 5.3e-10 39.5 0.0 2.3e-09 37.5 0.0 1.9 2 0 0 2 2 2 1 Oxidoreductase FAD-binding domain NAD_binding_6 PF08030.12 CAV17692.1 - 0.15 12.2 0.0 0.59 10.2 0.0 1.8 2 0 0 2 2 2 0 Ferric reductase NAD binding domain ApbE PF02424.15 CAV17693.1 - 6.8e-85 284.7 0.0 8.3e-85 284.4 0.0 1.1 1 0 0 1 1 1 1 ApbE family NqrM PF04400.13 CAV17695.1 - 1.3e-20 72.9 2.1 1.3e-20 72.9 2.1 1.5 2 0 0 2 2 2 1 (Na+)-NQR maturation NqrM Response_reg PF00072.24 CAV17696.1 - 1.2e-35 122.0 1.0 2.4e-22 79.2 0.1 2.3 2 0 0 2 2 2 2 Response regulator receiver domain GGDEF PF00990.21 CAV17696.1 - 1.2e-29 103.1 0.1 2.1e-29 102.3 0.1 1.4 1 0 0 1 1 1 1 Diguanylate cyclase, GGDEF domain OKR_DC_1_N PF03709.15 CAV17696.1 - 6.6e-05 23.2 1.0 0.036 14.3 0.0 2.8 3 0 0 3 3 3 2 Orn/Lys/Arg decarboxylase, N-terminal domain IMS PF00817.20 CAV17697.1 - 1.6e-47 161.2 0.0 2.6e-47 160.6 0.0 1.3 1 0 0 1 1 1 1 impB/mucB/samB family IMS_C PF11799.8 CAV17697.1 - 6.3e-07 30.1 0.2 1.2e-06 29.2 0.2 1.4 1 0 0 1 1 1 1 impB/mucB/samB family C-terminal domain IMS_HHH PF11798.8 CAV17697.1 - 2.2e-06 27.6 0.0 5.7e-06 26.4 0.0 1.8 1 0 0 1 1 1 1 IMS family HHH motif HHH_5 PF14520.6 CAV17697.1 - 0.0054 17.3 0.0 0.03 14.9 0.0 2.2 2 0 0 2 2 2 1 Helix-hairpin-helix domain Cdd1 PF11731.8 CAV17697.1 - 0.034 14.4 0.0 0.074 13.3 0.0 1.5 1 0 0 1 1 1 0 Pathogenicity locus Helicase_C PF00271.31 CAV17698.1 - 4.3e-22 78.6 1.7 1.8e-18 66.9 0.1 3.0 3 0 0 3 3 3 2 Helicase conserved C-terminal domain DEAD PF00270.29 CAV17698.1 - 6.8e-19 68.3 0.1 1.9e-18 66.8 0.1 1.8 1 0 0 1 1 1 1 DEAD/DEAH box helicase RecQ_Zn_bind PF16124.5 CAV17698.1 - 6.5e-10 39.6 1.4 3.1e-09 37.4 1.4 2.2 1 0 0 1 1 1 1 RecQ zinc-binding SNF2_N PF00176.23 CAV17698.1 - 0.012 14.3 0.1 0.022 13.5 0.1 1.5 1 0 0 1 1 1 0 SNF2 family N-terminal domain AAA_22 PF13401.6 CAV17698.1 - 0.025 14.8 0.1 0.28 11.4 0.0 2.6 2 1 0 2 2 2 0 AAA domain DUF1488 PF07369.11 CAV17698.1 - 0.082 12.9 0.1 0.34 10.9 0.1 2.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1488) DDE_3 PF13358.6 CAV17698.1 - 0.083 12.6 0.2 0.37 10.5 0.0 2.2 2 0 0 2 2 2 0 DDE superfamily endonuclease UPF0228 PF05727.11 CAV17698.1 - 0.22 11.3 2.6 0.55 10.1 0.0 2.8 3 1 1 4 4 4 0 Uncharacterised protein family (UPF0228) GreA_GreB PF01272.19 CAV17699.1 - 1.5e-08 34.4 0.0 3.6e-08 33.2 0.0 1.7 1 1 0 1 1 1 1 Transcription elongation factor, GreA/GreB, C-term sCache_3_2 PF17203.4 CAV17699.1 - 0.55 10.4 2.8 1.6 8.9 2.8 1.6 1 1 0 1 1 1 0 Single cache domain 3 DUF2884 PF11101.8 CAV17700.1 - 1.1e-74 250.8 8.5 1.2e-74 250.6 8.5 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2884) Apolipoprotein PF01442.18 CAV17700.1 - 0.00077 19.4 8.2 0.0036 17.2 8.2 1.9 1 1 0 1 1 1 1 Apolipoprotein A1/A4/E domain YtxH PF12732.7 CAV17700.1 - 0.014 15.9 7.0 0.45 11.1 0.1 3.0 1 1 1 2 2 2 0 YtxH-like protein PKI PF02827.16 CAV17700.1 - 0.026 14.7 0.3 0.062 13.5 0.3 1.6 1 0 0 1 1 1 0 cAMP-dependent protein kinase inhibitor TnpV PF14198.6 CAV17700.1 - 0.087 12.8 3.0 1.6 8.8 1.2 2.6 2 0 0 2 2 2 0 Transposon-encoded protein TnpV DUF1664 PF07889.12 CAV17700.1 - 0.21 11.6 3.0 0.45 10.6 1.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) DASH_Dam1 PF08653.10 CAV17700.1 - 0.24 11.2 2.6 9.9 6.0 0.3 3.0 1 1 1 2 2 2 0 DASH complex subunit Dam1 DUF883 PF05957.13 CAV17700.1 - 0.26 11.9 4.1 11 6.6 0.8 2.6 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF883) Nsp1_C PF05064.13 CAV17700.1 - 0.29 10.9 6.0 1.8 8.4 6.0 2.3 1 1 0 1 1 1 0 Nsp1-like C-terminal region Zn_ribbon_2 PF12674.7 CAV17700.1 - 0.68 10.6 4.0 17 6.1 0.0 3.4 2 1 1 3 3 3 0 Putative zinc ribbon domain YicC_N PF03755.13 CAV17700.1 - 0.79 10.2 5.0 2.4 8.6 2.1 2.2 2 0 0 2 2 2 0 YicC-like family, N-terminal region DUF3958 PF13125.6 CAV17700.1 - 6.7 7.0 13.2 13 6.1 6.2 2.7 2 1 1 3 3 3 0 Protein of unknown function (DUF3958) SNF PF00209.18 CAV17701.1 - 9.4e-46 156.6 36.3 3.2e-25 88.8 22.6 2.0 1 1 0 2 2 2 2 Sodium:neurotransmitter symporter family Radical_SAM PF04055.21 CAV17702.1 - 1.3e-19 71.1 0.0 1.9e-19 70.7 0.0 1.4 1 0 0 1 1 1 1 Radical SAM superfamily LIAS_N PF16881.5 CAV17702.1 - 5.7e-09 36.4 0.2 2.6e-08 34.2 0.1 2.0 2 0 0 2 2 2 1 N-terminal domain of lipoyl synthase of Radical_SAM family AP_endonuc_2 PF01261.24 CAV17702.1 - 0.00016 21.2 0.1 0.15 11.5 0.1 3.0 2 2 1 3 3 3 2 Xylose isomerase-like TIM barrel BPL_LplA_LipB PF03099.19 CAV17703.1 - 3.9e-08 33.3 0.0 7.2e-08 32.4 0.0 1.4 1 0 0 1 1 1 1 Biotin/lipoate A/B protein ligase family DUF493 PF04359.14 CAV17704.1 - 1.9e-28 98.9 0.0 2.5e-28 98.5 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF493) Peptidase_S11 PF00768.20 CAV17705.1 - 5e-93 311.0 0.6 6.9e-93 310.5 0.6 1.1 1 0 0 1 1 1 1 D-alanyl-D-alanine carboxypeptidase PBP5_C PF07943.13 CAV17705.1 - 5.1e-27 93.9 0.1 9.2e-27 93.1 0.1 1.5 1 0 0 1 1 1 1 Penicillin-binding protein 5, C-terminal domain Beta-lactamase2 PF13354.6 CAV17705.1 - 6.5e-08 32.4 0.0 9.8e-08 31.8 0.0 1.2 1 0 0 1 1 1 1 Beta-lactamase enzyme family Beta-lactamase PF00144.24 CAV17705.1 - 1.2e-05 24.8 0.0 9.8e-05 21.7 0.0 2.1 2 0 0 2 2 2 1 Beta-lactamase Peptidase_S13 PF02113.15 CAV17705.1 - 0.031 13.0 0.0 0.05 12.3 0.0 1.2 1 0 0 1 1 1 0 D-Ala-D-Ala carboxypeptidase 3 (S13) family DPBB_1 PF03330.18 CAV17706.1 - 2e-27 95.3 0.0 3.6e-27 94.5 0.0 1.4 1 0 0 1 1 1 1 Lytic transglycolase SPOR PF05036.13 CAV17706.1 - 1.2e-06 28.8 0.0 4.6e-06 26.9 0.0 2.0 2 0 0 2 2 2 1 Sporulation related domain FTSW_RODA_SPOVE PF01098.19 CAV17707.1 - 6.1e-111 370.9 30.5 7.3e-111 370.6 30.5 1.0 1 0 0 1 1 1 1 Cell cycle protein Transpeptidase PF00905.22 CAV17708.1 - 5.4e-78 262.3 0.0 7.2e-78 261.9 0.0 1.2 1 0 0 1 1 1 1 Penicillin binding protein transpeptidase domain PBP_dimer PF03717.15 CAV17708.1 - 1.3e-47 162.5 0.1 2.3e-47 161.7 0.1 1.4 1 0 0 1 1 1 1 Penicillin-binding Protein dimerisation domain SPOUT_MTase PF02590.17 CAV17709.1 - 2.4e-49 167.3 0.0 2.6e-49 167.1 0.0 1.0 1 0 0 1 1 1 1 Predicted SPOUT methyltransferase RsfS PF02410.15 CAV17710.1 - 7.3e-27 93.7 0.2 8.3e-27 93.5 0.2 1.0 1 0 0 1 1 1 1 Ribosomal silencing factor during starvation HupF_HypC PF01455.18 CAV17710.1 - 0.0081 16.3 0.3 0.095 12.9 0.1 2.0 1 1 1 2 2 2 1 HupF/HypC family Tox-MPTase2 PF15638.6 CAV17710.1 - 0.04 13.7 0.0 0.044 13.5 0.0 1.1 1 0 0 1 1 1 0 Metallopeptidase toxin 2 DUF2482 PF10655.9 CAV17710.1 - 0.13 12.8 0.8 0.99 9.9 0.1 2.0 2 0 0 2 2 2 0 Hypothetical protein of unknown function (DUF2482) DNA_pol3_delta PF06144.13 CAV17711.1 - 7.2e-48 162.6 1.0 7.9e-48 162.5 0.1 1.5 2 0 0 2 2 2 1 DNA polymerase III, delta subunit DNA_pol3_delt_C PF14840.6 CAV17711.1 - 8.3e-37 126.3 1.8 1.8e-36 125.2 1.8 1.6 1 0 0 1 1 1 1 Processivity clamp loader gamma complex DNA pol III C-term Shikimate_DH PF01488.20 CAV17711.1 - 0.031 14.3 0.0 0.096 12.7 0.0 1.8 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase DNA_pol3_gamma3 PF12169.8 CAV17711.1 - 0.042 13.8 1.1 0.081 12.8 0.3 1.9 2 0 0 2 2 2 0 DNA polymerase III subunits gamma and tau domain III LptE PF04390.12 CAV17712.1 - 2.1e-10 41.2 0.5 3.4e-10 40.6 0.5 1.3 1 0 0 1 1 1 1 Lipopolysaccharide-assembly DUF4101 PF13355.6 CAV17712.1 - 0.15 12.5 1.2 0.31 11.5 0.7 1.8 1 1 0 2 2 2 0 Protein of unknown function (DUF4101) tRNA-synt_1_2 PF13603.6 CAV17713.1 - 3.1e-79 264.8 0.0 6.4e-79 263.8 0.0 1.6 1 0 0 1 1 1 1 Leucyl-tRNA synthetase, Domain 2 tRNA-synt_1 PF00133.22 CAV17713.1 - 8e-74 249.0 12.3 1e-25 90.1 0.5 6.0 2 1 3 5 5 5 5 tRNA synthetases class I (I, L, M and V) tRNA-synt_1g PF09334.11 CAV17713.1 - 7.3e-32 110.6 0.1 2.4e-22 79.2 0.0 4.0 3 1 1 4 4 4 3 tRNA synthetases class I (M) Anticodon_1 PF08264.13 CAV17713.1 - 1.1e-16 61.1 0.2 2.1e-16 60.2 0.2 1.4 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1e PF01406.19 CAV17713.1 - 0.00017 21.1 0.0 0.29 10.4 0.0 2.3 2 0 0 2 2 2 2 tRNA synthetases class I (C) catalytic domain tRNA-synt_1f PF01921.18 CAV17713.1 - 0.00084 18.3 0.0 0.64 8.9 0.0 2.4 2 0 0 2 2 2 2 tRNA synthetases class I (K) DUF1451 PF07295.11 CAV17714.1 - 1.7e-49 167.6 0.0 1.9e-49 167.5 0.0 1.0 1 0 0 1 1 1 1 Zinc-ribbon containing domain Ribosomal_S27e PF01667.17 CAV17714.1 - 0.0046 16.6 1.4 0.0075 16.0 1.4 1.3 1 0 0 1 1 1 1 Ribosomal protein S27 A2L_zn_ribbon PF08792.10 CAV17714.1 - 0.017 14.8 1.8 0.036 13.8 1.8 1.5 1 0 0 1 1 1 0 A2L zinc ribbon domain Zn-ribbon_8 PF09723.10 CAV17714.1 - 0.027 14.6 0.9 0.051 13.7 0.9 1.4 1 0 0 1 1 1 0 Zinc ribbon domain PhnA_Zn_Ribbon PF08274.12 CAV17714.1 - 0.033 14.1 2.0 0.2 11.7 0.2 2.3 2 0 0 2 2 2 0 PhnA Zinc-Ribbon zf-RRN7 PF11781.8 CAV17714.1 - 0.11 12.2 2.9 0.2 11.4 0.6 2.1 2 0 0 2 2 2 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 HypA PF01155.19 CAV17714.1 - 0.14 12.2 0.9 0.24 11.4 0.2 1.6 2 0 0 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA TF_Zn_Ribbon PF08271.12 CAV17714.1 - 0.22 11.1 3.2 0.33 10.5 0.3 2.2 1 1 0 1 1 1 0 TFIIB zinc-binding CN_hydrolase PF00795.22 CAV17715.1 - 1e-34 120.0 0.0 1.4e-34 119.6 0.0 1.2 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase BaxI_1 PF12811.7 CAV17715.1 - 0.13 11.8 8.4 0.017 14.7 3.5 1.8 2 0 0 2 2 2 0 Bax inhibitor 1 like CbiQ PF02361.16 CAV17715.1 - 0.57 9.8 11.0 1.1 8.9 6.0 2.3 2 0 0 2 2 2 0 Cobalt transport protein CorC_HlyC PF03471.17 CAV17716.1 - 5.3e-22 77.6 1.2 1.7e-21 76.0 0.1 2.3 2 0 0 2 2 2 1 Transporter associated domain CBS PF00571.28 CAV17716.1 - 2.6e-16 59.8 7.3 1.9e-08 34.6 0.3 3.0 3 0 0 3 3 3 2 CBS domain DUF5406 PF17400.2 CAV17716.1 - 0.0029 18.0 0.4 0.0061 17.0 0.4 1.5 1 0 0 1 1 1 1 Family of unknown function (DUF5406) DUF3150 PF11348.8 CAV17716.1 - 0.057 12.6 0.0 0.081 12.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3150) DUF5607 PF18355.1 CAV17716.1 - 0.17 12.4 0.7 0.56 10.7 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF5607) UPF0054 PF02130.17 CAV17717.1 - 1.4e-39 134.8 0.2 1.6e-39 134.6 0.2 1.0 1 0 0 1 1 1 1 Uncharacterized protein family UPF0054 PhoH PF02562.16 CAV17718.1 - 8.3e-95 316.1 0.0 1.1e-94 315.6 0.0 1.2 1 0 0 1 1 1 1 PhoH-like protein AAA_30 PF13604.6 CAV17718.1 - 9.6e-09 35.2 0.0 2.1e-08 34.1 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 CAV17718.1 - 5.6e-05 23.5 0.2 0.00024 21.4 0.2 2.0 1 1 0 1 1 1 1 AAA domain IstB_IS21 PF01695.17 CAV17718.1 - 0.0017 18.1 0.0 0.0065 16.2 0.0 2.0 2 0 0 2 2 2 1 IstB-like ATP binding protein AAA_22 PF13401.6 CAV17718.1 - 0.012 15.9 0.0 0.036 14.3 0.0 1.8 1 1 0 1 1 1 0 AAA domain AAA_25 PF13481.6 CAV17718.1 - 0.029 13.9 0.0 0.063 12.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain Zot PF05707.12 CAV17718.1 - 0.034 13.8 0.0 7 6.2 0.0 2.5 2 1 0 2 2 2 0 Zonular occludens toxin (Zot) DEAD PF00270.29 CAV17718.1 - 0.048 13.4 0.1 0.32 10.8 0.0 2.2 2 0 0 2 2 2 0 DEAD/DEAH box helicase Ribosom_S30AE_C PF16321.5 CAV17718.1 - 0.083 12.6 0.0 0.25 11.0 0.0 1.8 1 0 0 1 1 1 0 Sigma 54 modulation/S30EA ribosomal protein C terminus UPF0004 PF00919.20 CAV17719.1 - 2.9e-29 101.0 0.0 5.9e-29 100.0 0.0 1.6 1 0 0 1 1 1 1 Uncharacterized protein family UPF0004 Radical_SAM PF04055.21 CAV17719.1 - 3.9e-28 98.9 0.1 8.8e-28 97.8 0.0 1.6 2 0 0 2 2 2 1 Radical SAM superfamily TRAM PF01938.20 CAV17719.1 - 3.3e-19 68.6 0.1 6.2e-19 67.7 0.1 1.5 1 0 0 1 1 1 1 TRAM domain TRAM_2 PF18693.1 CAV17719.1 - 0.0027 17.8 0.1 0.0088 16.2 0.1 1.9 1 1 0 1 1 1 1 TRAM domain FAD_binding_3 PF01494.19 CAV17720.1 - 3.3e-30 105.5 0.0 5.6e-29 101.5 0.0 2.0 1 1 0 1 1 1 1 FAD binding domain Trp_halogenase PF04820.14 CAV17720.1 - 2.4e-05 23.4 2.9 0.012 14.5 0.0 2.8 3 0 0 3 3 3 2 Tryptophan halogenase DAO PF01266.24 CAV17720.1 - 4.3e-05 23.3 4.8 0.00019 21.1 4.8 2.2 1 1 0 1 1 1 1 FAD dependent oxidoreductase SE PF08491.10 CAV17720.1 - 4.6e-05 22.6 0.0 6.3e-05 22.2 0.0 1.2 1 0 0 1 1 1 1 Squalene epoxidase FAD_binding_2 PF00890.24 CAV17720.1 - 0.00019 20.6 1.6 0.00046 19.4 1.3 1.7 2 0 0 2 2 2 1 FAD binding domain Pyr_redox_2 PF07992.14 CAV17720.1 - 0.00089 18.6 0.1 0.0016 17.7 0.1 1.5 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 CAV17720.1 - 0.0028 16.8 0.4 0.012 14.7 0.4 1.8 2 0 0 2 2 2 1 Glucose inhibited division protein A Lycopene_cycl PF05834.12 CAV17720.1 - 0.0081 15.2 0.3 0.49 9.4 0.4 2.1 2 0 0 2 2 2 1 Lycopene cyclase protein 3HCDH_N PF02737.18 CAV17720.1 - 0.0093 15.9 0.4 0.017 15.0 0.4 1.4 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain FAD_oxidored PF12831.7 CAV17720.1 - 0.011 15.1 5.5 0.017 14.5 5.5 1.2 1 0 0 1 1 1 0 FAD dependent oxidoreductase Pyr_redox PF00070.27 CAV17720.1 - 0.025 15.1 1.0 0.054 14.0 0.5 1.9 2 0 0 2 2 1 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_7 PF13241.6 CAV17720.1 - 0.031 14.7 0.0 0.085 13.3 0.0 1.7 2 0 0 2 2 2 0 Putative NAD(P)-binding UDPG_MGDP_dh_N PF03721.14 CAV17720.1 - 0.036 13.6 0.4 0.07 12.7 0.4 1.5 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain NAD_binding_8 PF13450.6 CAV17720.1 - 0.047 13.9 3.0 0.14 12.4 3.0 1.8 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 CAV17720.1 - 0.058 12.6 0.8 0.088 12.0 0.4 1.5 2 0 0 2 2 2 0 Thi4 family HI0933_like PF03486.14 CAV17720.1 - 0.19 10.4 2.0 0.38 9.4 2.0 1.5 1 0 0 1 1 1 0 HI0933-like protein Lactonase PF10282.9 CAV17721.1 - 4.8e-90 302.3 0.0 5.4e-90 302.1 0.0 1.0 1 0 0 1 1 1 1 Lactonase, 7-bladed beta-propeller DUF4580 PF15162.6 CAV17722.1 - 0.092 12.3 0.1 0.12 12.0 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4580) YchF-GTPase_C PF06071.13 CAV17723.1 - 1.6e-39 133.9 0.3 4.9e-39 132.4 0.1 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF933) MMR_HSR1 PF01926.23 CAV17723.1 - 3.2e-22 78.7 0.0 8.7e-22 77.4 0.0 1.7 2 0 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 CAV17723.1 - 1.7e-08 34.1 0.1 5e-08 32.6 0.0 1.8 2 0 0 2 2 2 1 Ferrous iron transport protein B TGS PF02824.21 CAV17723.1 - 2.8e-05 24.1 0.1 0.00012 22.0 0.0 2.1 2 0 0 2 2 2 1 TGS domain Pept_tRNA_hydro PF01195.19 CAV17724.1 - 6e-55 185.8 0.0 6.9e-55 185.6 0.0 1.0 1 0 0 1 1 1 1 Peptidyl-tRNA hydrolase Pribosyltran_N PF13793.6 CAV17725.1 - 3.9e-51 171.9 0.2 7.3e-50 167.8 0.0 2.4 2 1 0 2 2 2 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyl_synth PF14572.6 CAV17725.1 - 4.8e-30 104.9 0.5 7.7e-30 104.3 0.5 1.4 1 0 0 1 1 1 1 Phosphoribosyl synthetase-associated domain Pribosyltran PF00156.27 CAV17725.1 - 2.5e-22 79.1 3.5 6.8e-21 74.4 1.4 2.4 2 1 0 2 2 2 2 Phosphoribosyl transferase domain UPRTase PF14681.6 CAV17725.1 - 0.0003 20.3 0.0 0.00048 19.6 0.0 1.3 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase PRTase_2 PF15609.6 CAV17725.1 - 0.092 12.2 0.1 0.17 11.4 0.1 1.4 1 0 0 1 1 1 0 Phosphoribosyl transferase GHMP_kinases_N PF00288.26 CAV17726.1 - 9.4e-10 38.6 0.0 1.7e-09 37.8 0.0 1.5 1 0 0 1 1 1 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.13 CAV17726.1 - 2.3e-07 31.1 0.0 4e-07 30.3 0.0 1.4 1 0 0 1 1 1 1 GHMP kinases C terminal NMT PF01233.19 CAV17726.1 - 0.079 12.8 0.0 0.12 12.2 0.0 1.3 1 0 0 1 1 1 0 Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain LolB PF03550.14 CAV17728.1 - 2.3e-43 147.9 2.9 3.2e-43 147.4 2.9 1.2 1 0 0 1 1 1 1 Outer membrane lipoprotein LolB GlutR_N PF05201.15 CAV17729.1 - 1.7e-53 180.3 0.1 3.6e-53 179.3 0.1 1.6 1 0 0 1 1 1 1 Glutamyl-tRNAGlu reductase, N-terminal domain Shikimate_DH PF01488.20 CAV17729.1 - 2.1e-49 167.1 0.1 3.8e-49 166.3 0.1 1.4 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase GlutR_dimer PF00745.20 CAV17729.1 - 2.8e-23 82.2 1.0 7e-23 80.9 0.3 2.1 2 0 0 2 2 2 1 Glutamyl-tRNAGlu reductase, dimerisation domain F420_oxidored PF03807.17 CAV17729.1 - 1.2e-05 25.8 0.1 0.00018 22.0 0.1 2.8 2 0 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent 2-Hacid_dh_C PF02826.19 CAV17729.1 - 0.00071 19.0 0.0 0.0013 18.2 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain OCD_Mu_crystall PF02423.15 CAV17729.1 - 0.0056 15.7 0.2 0.011 14.7 0.2 1.4 1 0 0 1 1 1 1 Ornithine cyclodeaminase/mu-crystallin family NAD_binding_7 PF13241.6 CAV17729.1 - 0.059 13.8 0.0 0.18 12.3 0.0 1.8 1 0 0 1 1 1 0 Putative NAD(P)-binding PCRF PF03462.18 CAV17730.1 - 1.7e-75 253.2 0.5 1.7e-75 253.2 0.5 1.6 2 0 0 2 2 2 1 PCRF domain RF-1 PF00472.20 CAV17730.1 - 3.2e-38 130.2 0.2 3.2e-38 130.2 0.2 2.4 3 0 0 3 3 3 1 RF-1 domain HR1 PF02185.16 CAV17730.1 - 0.0016 18.5 1.0 0.0044 17.1 1.0 1.8 1 0 0 1 1 1 1 Hr1 repeat Phage_Mu_Gam PF07352.12 CAV17730.1 - 0.016 15.1 5.5 0.016 15.1 5.5 1.7 2 0 0 2 2 2 0 Bacteriophage Mu Gam like protein ABC_tran_CTD PF16326.5 CAV17730.1 - 0.027 14.7 0.1 0.027 14.7 0.1 3.1 3 0 0 3 3 3 0 ABC transporter C-terminal domain MIR PF02815.19 CAV17730.1 - 0.11 12.3 0.9 0.8 9.5 0.0 2.3 3 0 0 3 3 3 0 MIR domain IFT20 PF14931.6 CAV17730.1 - 0.37 11.0 6.6 2.8 8.1 2.0 2.5 2 1 0 2 2 2 0 Intraflagellar transport complex B, subunit 20 DUF4407 PF14362.6 CAV17730.1 - 1.4 8.2 5.5 0.7 9.2 1.3 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) PrmC_N PF17827.1 CAV17731.1 - 1.5e-20 73.5 0.0 2.9e-20 72.6 0.0 1.5 1 0 0 1 1 1 1 PrmC N-terminal domain Methyltransf_31 PF13847.6 CAV17731.1 - 4.7e-17 62.2 0.0 7e-17 61.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 CAV17731.1 - 1.4e-11 44.3 0.0 2.9e-11 43.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_25 PF13649.6 CAV17731.1 - 9e-10 39.1 0.0 1.8e-09 38.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 CAV17731.1 - 1e-06 28.4 0.0 1.5e-06 27.8 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_23 PF13489.6 CAV17731.1 - 3.7e-06 26.9 0.0 9.4e-06 25.6 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Cons_hypoth95 PF03602.15 CAV17731.1 - 1.4e-05 24.8 0.0 7e-05 22.5 0.0 2.0 1 1 0 1 1 1 1 Conserved hypothetical protein 95 Methyltransf_11 PF08241.12 CAV17731.1 - 2.9e-05 24.6 0.0 7.8e-05 23.2 0.0 1.7 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_4 PF02390.17 CAV17731.1 - 6.1e-05 22.6 0.0 0.00014 21.4 0.0 1.6 2 0 0 2 2 2 1 Putative methyltransferase Methyltransf_32 PF13679.6 CAV17731.1 - 0.00062 19.8 0.0 0.00091 19.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_16 PF10294.9 CAV17731.1 - 0.00096 18.9 0.0 0.0015 18.3 0.0 1.3 1 0 0 1 1 1 1 Lysine methyltransferase N6_Mtase PF02384.16 CAV17731.1 - 0.0012 18.2 0.0 0.0016 17.8 0.0 1.1 1 0 0 1 1 1 1 N-6 DNA Methylase Methyltransf_12 PF08242.12 CAV17731.1 - 0.0013 19.4 0.0 0.003 18.3 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain UPF0020 PF01170.18 CAV17731.1 - 0.0041 16.8 0.0 0.007 16.1 0.0 1.3 1 0 0 1 1 1 1 Putative RNA methylase family UPF0020 Methyltransf_2 PF00891.18 CAV17731.1 - 0.012 14.9 0.0 0.022 14.1 0.0 1.3 1 0 0 1 1 1 0 O-methyltransferase domain DOT1 PF08123.13 CAV17731.1 - 0.016 14.8 0.0 0.024 14.2 0.0 1.2 1 0 0 1 1 1 0 Histone methylation protein DOT1 Reovirus_L2 PF06016.11 CAV17731.1 - 0.023 12.0 0.0 0.029 11.6 0.0 1.0 1 0 0 1 1 1 0 Reovirus core-spike protein lambda-2 (L2) Methyltransf_18 PF12847.7 CAV17731.1 - 0.047 13.6 0.0 0.1 12.5 0.0 1.5 2 0 0 2 2 1 0 Methyltransferase domain PCMT PF01135.19 CAV17731.1 - 0.048 13.4 0.0 0.073 12.8 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Ubie_methyltran PF01209.18 CAV17731.1 - 0.056 12.8 0.0 0.15 11.3 0.0 1.6 2 0 0 2 2 2 0 ubiE/COQ5 methyltransferase family DUF348 PF03990.14 CAV17731.1 - 0.084 12.6 0.0 0.23 11.2 0.0 1.8 1 0 0 1 1 1 0 G5-linked-Ubiquitin-like domain DUF938 PF06080.12 CAV17731.1 - 0.1 12.3 0.0 0.2 11.4 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF938) Met_10 PF02475.16 CAV17731.1 - 0.11 12.2 0.0 0.19 11.5 0.0 1.3 1 0 0 1 1 1 0 Met-10+ like-protein Methyltransf_5 PF01795.19 CAV17731.1 - 0.14 11.6 0.0 0.21 11.1 0.0 1.1 1 0 0 1 1 1 0 MraW methylase family Eco57I PF07669.11 CAV17731.1 - 0.16 12.5 0.0 0.34 11.4 0.0 1.6 1 0 0 1 1 1 0 Eco57I restriction-modification methylase RrnaAD PF00398.20 CAV17731.1 - 0.21 10.6 0.0 0.34 10.0 0.0 1.2 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase SirB PF04247.12 CAV17732.1 - 6.2e-39 132.8 3.2 6.9e-39 132.7 3.2 1.0 1 0 0 1 1 1 1 Invasion gene expression up-regulator, SirB DUF2582 PF10771.9 CAV17732.1 - 0.14 12.3 0.0 0.23 11.7 0.0 1.4 1 0 0 1 1 1 0 Winged helix-turn-helix domain (DUF2582) Transglut_core2 PF13369.6 CAV17733.1 - 1.4e-41 141.7 0.0 1.8e-41 141.3 0.0 1.1 1 0 0 1 1 1 1 Transglutaminase-like superfamily TPR_9 PF13371.6 CAV17733.1 - 6.7e-24 83.8 0.1 6.7e-24 83.8 0.1 1.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_2 PF07719.17 CAV17733.1 - 0.016 15.3 0.4 4.5 7.6 0.0 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat DAHP_synth_1 PF00793.20 CAV17734.1 - 5e-70 235.5 0.0 5.7e-70 235.3 0.0 1.0 1 0 0 1 1 1 1 DAHP synthetase I family 5_nucleotid_C PF02872.18 CAV17735.1 - 1.5e-34 119.5 0.7 3.6e-34 118.3 0.7 1.7 1 0 0 1 1 1 1 5'-nucleotidase, C-terminal domain Metallophos PF00149.28 CAV17735.1 - 7.6e-22 78.8 0.1 1.2e-21 78.2 0.1 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase YmdB PF13277.6 CAV17735.1 - 0.013 14.8 0.0 0.027 13.8 0.0 1.5 1 0 0 1 1 1 0 YmdB-like protein DUF3176 PF11374.8 CAV17735.1 - 0.099 12.9 0.0 0.18 12.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3176) tRNA_edit PF04073.15 CAV17737.1 - 2.6e-26 92.1 0.2 3.1e-26 91.9 0.2 1.1 1 0 0 1 1 1 1 Aminoacyl-tRNA editing domain SpoU_sub_bind PF08032.12 CAV17737.1 - 0.11 12.7 0.1 1 9.7 0.0 2.6 3 1 0 3 3 3 0 RNA 2'-O ribose methyltransferase substrate binding PseudoU_synth_2 PF00849.22 CAV17738.1 - 2.2e-13 50.6 4.3 3.4e-13 50.0 0.1 2.8 2 2 0 2 2 2 1 RNA pseudouridylate synthase S4 PF01479.25 CAV17738.1 - 3.7e-11 42.6 0.0 8.9e-11 41.3 0.0 1.7 1 0 0 1 1 1 1 S4 domain S4_2 PF13275.6 CAV17738.1 - 0.019 14.8 0.0 0.043 13.6 0.0 1.6 1 0 0 1 1 1 0 S4 domain Smr PF01713.21 CAV17739.1 - 1.2e-20 73.6 0.0 2.3e-20 72.7 0.0 1.5 1 0 0 1 1 1 1 Smr domain TraB PF01963.17 CAV17744.1 - 2.2e-53 181.9 0.5 2.6e-53 181.6 0.5 1.0 1 0 0 1 1 1 1 TraB family Glyco_hydro_20 PF00728.22 CAV17745.1 - 1.5e-102 343.6 0.1 2e-102 343.2 0.1 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 20, catalytic domain CHB_HEX PF03173.13 CAV17745.1 - 4.7e-63 211.6 0.0 9.3e-63 210.7 0.0 1.5 1 0 0 1 1 1 1 Putative carbohydrate binding domain CHB_HEX_C PF03174.13 CAV17745.1 - 1e-26 92.7 0.0 2.4e-26 91.5 0.0 1.7 1 0 0 1 1 1 1 Chitobiase/beta-hexosaminidase C-terminal domain Glyco_hydro_20b PF02838.15 CAV17745.1 - 9.5e-14 52.2 0.0 2.5e-13 50.9 0.0 1.8 1 0 0 1 1 1 1 Glycosyl hydrolase family 20, domain 2 KdgM PF06178.13 CAV17746.1 - 5.8e-05 22.8 0.9 9.8e-05 22.1 0.8 1.5 1 1 0 1 1 1 1 Oligogalacturonate-specific porin protein (KdgM) DUF411 PF04214.13 CAV17748.1 - 1.9e-32 111.0 0.2 2.6e-32 110.5 0.2 1.2 1 0 0 1 1 1 1 Protein of unknown function, DUF E1-E2_ATPase PF00122.20 CAV17749.1 - 1.7e-51 174.3 6.5 1.7e-51 174.3 6.5 2.2 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.26 CAV17749.1 - 2e-43 149.1 1.9 2.3e-43 148.9 0.4 1.9 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase HMA PF00403.26 CAV17749.1 - 2.7e-21 75.8 6.5 3.1e-13 49.9 0.3 4.2 4 0 0 4 4 4 3 Heavy-metal-associated domain Hydrolase_3 PF08282.12 CAV17749.1 - 4.3e-07 29.9 4.4 4.1e-05 23.5 0.2 3.0 3 0 0 3 3 3 2 haloacid dehalogenase-like hydrolase HAD PF12710.7 CAV17749.1 - 7.8e-05 23.1 0.0 0.0004 20.8 0.0 2.1 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase T2SSF PF00482.23 CAV17749.1 - 0.0056 16.6 5.5 3.9 7.5 0.1 3.8 3 0 0 3 3 3 2 Type II secretion system (T2SS), protein F Pox_E10 PF04805.12 CAV17749.1 - 0.23 11.3 1.0 3.8 7.5 0.1 2.9 3 0 0 3 3 3 0 E10-like protein conserved region DUF983 PF06170.12 CAV17749.1 - 0.95 9.9 6.0 4.1 7.9 6.0 2.1 1 0 0 1 1 1 0 Protein of unknown function (DUF983) DUF3391 PF11871.8 CAV17749.1 - 0.97 10.0 0.0 0.97 10.0 0.0 3.0 3 1 0 3 3 2 0 Domain of unknown function (DUF3391) DUF3493 PF11998.8 CAV17749.1 - 2.1 8.6 4.1 12 6.2 0.1 3.1 2 0 0 2 2 2 0 Low psii accumulation1 / Rep27 Phage_holin_3_6 PF07332.11 CAV17749.1 - 3.7 7.6 15.3 0.45 10.6 0.7 3.3 3 1 0 3 3 3 0 Putative Actinobacterial Holin-X, holin superfamily III DNA_RNApol_7kD PF03604.13 CAV17749.1 - 4.8 7.0 4.6 93 2.8 0.1 3.3 3 0 0 3 3 3 0 DNA directed RNA polymerase, 7 kDa subunit HAD_2 PF13419.6 CAV17749.1 - 5.1 7.1 5.8 1.6 8.8 0.5 2.8 3 1 0 3 3 3 0 Haloacid dehalogenase-like hydrolase tRNA-synt_1c PF00749.21 CAV17750.1 - 3.4e-114 381.0 0.0 4.2e-114 380.7 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain ketoacyl-synt PF00109.26 CAV17752.1 - 2.4e-43 148.6 0.7 2.4e-42 145.3 0.3 2.0 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.22 CAV17752.1 - 6.7e-29 100.3 0.2 1.5e-28 99.2 0.1 1.7 2 0 0 2 2 2 1 Beta-ketoacyl synthase, C-terminal domain Thiolase_N PF00108.23 CAV17752.1 - 0.0001 21.7 0.1 0.0005 19.5 0.0 2.0 2 0 0 2 2 2 1 Thiolase, N-terminal domain ACP_syn_III PF08545.10 CAV17752.1 - 0.038 13.9 0.2 1.9 8.4 0.1 2.6 2 0 0 2 2 2 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III adh_short_C2 PF13561.6 CAV17753.1 - 2.7e-58 197.3 0.6 3e-58 197.1 0.6 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CAV17753.1 - 8.6e-51 172.2 0.9 1e-50 171.9 0.9 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CAV17753.1 - 9.8e-20 71.2 0.2 1.5e-19 70.6 0.2 1.3 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 CAV17753.1 - 0.0022 17.5 0.1 0.0034 16.9 0.1 1.4 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family FabA PF07977.13 CAV17754.1 - 0.0062 16.2 0.0 0.0095 15.6 0.0 1.4 1 1 0 1 1 1 1 FabA-like domain Ketoacyl-synt_C PF02801.22 CAV17755.1 - 4.7e-28 97.6 0.1 9.8e-28 96.6 0.1 1.5 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain ketoacyl-synt PF00109.26 CAV17755.1 - 1.1e-23 84.1 0.4 1.8e-23 83.4 0.4 1.3 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Thiolase_N PF00108.23 CAV17755.1 - 0.0031 16.9 1.9 0.012 15.0 0.1 2.5 3 0 0 3 3 3 1 Thiolase, N-terminal domain ACP_syn_III PF08545.10 CAV17755.1 - 0.0093 15.8 1.2 0.039 13.8 0.5 2.3 2 1 0 2 2 2 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III DUF3261 PF11659.8 CAV17756.1 - 1.2e-36 125.6 2.1 1.4e-36 125.4 2.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3261) POM121 PF15229.6 CAV17756.1 - 0.16 11.6 0.0 0.25 11.0 0.0 1.2 1 0 0 1 1 1 0 POM121 family DUF3918 PF13056.6 CAV17756.1 - 0.27 10.9 0.2 0.61 9.7 0.1 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3918) MMPL PF03176.15 CAV17757.1 - 4.3e-09 35.7 11.5 4.3e-09 35.7 11.5 4.3 3 2 0 3 3 3 2 MMPL family DUF1824 PF08854.10 CAV17757.1 - 0.18 11.7 2.1 0.22 11.4 0.2 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF1824) DUF4358 PF14270.6 CAV17757.1 - 0.21 11.9 1.0 0.83 10.0 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4358) Sterol-sensing PF12349.8 CAV17757.1 - 1.7 8.4 16.0 0.94 9.3 0.8 3.9 3 2 1 4 4 4 0 Sterol-sensing domain of SREBP cleavage-activation DUF4179 PF13786.6 CAV17757.1 - 2.1 8.9 4.2 2.3 8.7 0.1 3.4 2 1 0 2 2 2 0 Domain of unknown function (DUF4179) LolA PF03548.15 CAV17758.1 - 2.2e-09 37.2 0.6 1.9e-07 30.9 0.6 2.2 1 1 0 1 1 1 1 Outer membrane lipoprotein carrier protein LolA 4HBT_2 PF13279.6 CAV17760.1 - 3.5e-11 43.7 0.6 3.9e-11 43.5 0.6 1.1 1 0 0 1 1 1 1 Thioesterase-like superfamily 4HBT PF03061.22 CAV17760.1 - 8.2e-08 32.5 0.0 1.6e-07 31.5 0.0 1.5 1 1 0 1 1 1 1 Thioesterase superfamily Lyase_aromatic PF00221.19 CAV17761.1 - 4e-163 543.4 0.1 4.6e-163 543.2 0.1 1.0 1 0 0 1 1 1 1 Aromatic amino acid lyase TAFH PF07531.14 CAV17761.1 - 0.12 12.4 0.0 0.36 10.9 0.0 1.8 1 0 0 1 1 1 0 NHR1 homology to TAF Glycos_transf_2 PF00535.26 CAV17762.1 - 6.8e-19 68.3 0.0 1.5e-18 67.2 0.0 1.6 1 0 0 1 1 1 1 Glycosyl transferase family 2 Lip_A_acyltrans PF03279.13 CAV17762.1 - 7.6e-13 48.3 0.0 1.3e-12 47.5 0.0 1.3 1 0 0 1 1 1 1 Bacterial lipid A biosynthesis acyltransferase Glyco_tranf_2_3 PF13641.6 CAV17762.1 - 0.0024 17.8 0.0 0.014 15.3 0.0 2.1 2 0 0 2 2 2 1 Glycosyltransferase like family 2 FabA PF07977.13 CAV17763.1 - 0.00035 20.2 0.1 0.0023 17.5 0.1 2.0 1 1 0 1 1 1 1 FabA-like domain AMP-binding PF00501.28 CAV17765.1 - 3.7e-17 62.1 0.0 5.7e-15 54.8 0.0 2.7 1 1 1 2 2 2 2 AMP-binding enzyme AMP-binding_C PF13193.6 CAV17765.1 - 1.7e-06 28.9 0.0 3.6e-06 27.8 0.0 1.6 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain IspA PF04279.15 CAV17766.1 - 2e-08 34.6 6.2 3.2e-08 33.9 4.2 1.7 1 1 1 2 2 2 1 Intracellular septation protein A Erg28 PF03694.13 CAV17766.1 - 0.0065 16.8 0.7 0.0065 16.8 0.7 2.0 2 1 1 3 3 3 1 Erg28 like protein DUF3382 PF11862.8 CAV17766.1 - 0.12 12.7 0.3 0.12 12.7 0.3 2.5 2 1 1 3 3 3 0 Domain of unknown function (DUF3382) CcmD PF04995.14 CAV17766.1 - 8.3 6.6 9.5 4 7.6 0.0 3.4 4 0 0 4 4 4 0 Heme exporter protein D (CcmD) PP-binding PF00550.25 CAV17767.1 - 1.2e-12 48.0 0.3 1.4e-12 47.8 0.3 1.1 1 0 0 1 1 1 1 Phosphopantetheine attachment site GCIP PF13324.6 CAV17767.1 - 0.0026 17.4 1.6 0.0029 17.2 1.6 1.0 1 0 0 1 1 1 1 Grap2 and cyclin-D-interacting CagD PF16567.5 CAV17767.1 - 0.011 15.5 1.2 0.012 15.4 1.2 1.1 1 0 0 1 1 1 0 Pathogenicity island component CagD PP-binding PF00550.25 CAV17768.1 - 1.9e-09 37.7 0.3 2.4e-09 37.4 0.3 1.1 1 0 0 1 1 1 1 Phosphopantetheine attachment site Acyltransferase PF01553.21 CAV17769.1 - 1.3e-14 54.0 0.0 2e-14 53.4 0.0 1.4 1 1 0 1 1 1 1 Acyltransferase Ketoacyl-synt_2 PF13723.6 CAV17770.1 - 3.8e-78 262.2 0.6 4.4e-78 262.0 0.6 1.0 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Methyltransf_2 PF00891.18 CAV17773.1 - 3.1e-12 46.3 0.0 4.8e-12 45.6 0.0 1.2 1 0 0 1 1 1 1 O-methyltransferase domain Methyltransf_23 PF13489.6 CAV17773.1 - 5.2e-09 36.1 0.0 7.6e-09 35.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CAV17773.1 - 3.1e-05 24.6 0.0 6.2e-05 23.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CAV17773.1 - 0.0042 17.8 0.0 0.014 16.1 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Trp_halogenase PF04820.14 CAV17774.1 - 6.6e-25 87.9 0.0 3.1e-13 49.4 0.1 2.6 1 1 1 2 2 2 2 Tryptophan halogenase FAD_binding_3 PF01494.19 CAV17774.1 - 3.6e-16 59.3 0.0 4.5e-16 59.0 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain FAD_oxidored PF12831.7 CAV17774.1 - 1.9e-07 30.8 0.2 3.7e-07 29.9 0.2 1.4 1 1 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 CAV17774.1 - 5.7e-06 26.5 0.0 2.5e-05 24.4 0.0 2.0 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.14 CAV17774.1 - 0.00019 20.3 0.0 0.00062 18.6 0.0 1.8 2 0 0 2 2 2 1 HI0933-like protein Thi4 PF01946.17 CAV17774.1 - 0.00025 20.4 0.0 0.00047 19.5 0.0 1.4 1 0 0 1 1 1 1 Thi4 family Pyr_redox_2 PF07992.14 CAV17774.1 - 0.00041 19.7 0.0 0.00093 18.5 0.0 1.5 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 CAV17774.1 - 0.0009 18.9 0.0 0.089 12.4 0.0 2.1 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox PF00070.27 CAV17774.1 - 0.0032 18.0 0.1 0.027 15.0 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 CAV17774.1 - 0.0099 15.2 0.1 0.018 14.3 0.1 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 CAV17774.1 - 0.011 14.9 0.0 0.027 13.6 0.0 1.6 2 0 0 2 2 2 0 FAD binding domain GIDA PF01134.22 CAV17774.1 - 0.012 14.8 0.0 0.015 14.4 0.0 1.2 1 0 0 1 1 1 0 Glucose inhibited division protein A K_oxygenase PF13434.6 CAV17774.1 - 0.019 14.1 0.0 0.76 8.9 0.0 2.1 2 0 0 2 2 2 0 L-lysine 6-monooxygenase (NADPH-requiring) Lycopene_cycl PF05834.12 CAV17774.1 - 0.077 12.0 0.0 0.68 8.9 0.0 2.0 2 0 0 2 2 2 0 Lycopene cyclase protein Shikimate_DH PF01488.20 CAV17774.1 - 0.16 12.0 0.0 0.27 11.3 0.0 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase FlgT_M PF16539.5 CAV17778.1 - 3.1e-39 134.6 0.2 6.3e-39 133.6 0.2 1.5 1 0 0 1 1 1 1 Flagellar assembly protein T, middle domain FlgT_N PF16548.5 CAV17778.1 - 1.6e-27 95.9 0.0 2.2e-26 92.3 0.0 2.5 2 0 0 2 2 2 1 Flagellar assembly protein T, N-terminal domain FlgT_C PF16538.5 CAV17778.1 - 1.8e-26 92.4 0.1 3.5e-26 91.5 0.1 1.5 1 0 0 1 1 1 1 Flagellar assembly protein T, C-terminal domain PPK2 PF03976.14 CAV17778.1 - 0.038 13.5 0.0 0.22 11.0 0.0 1.9 2 0 0 2 2 2 0 Polyphosphate kinase 2 (PPK2) FlgO PF17680.1 CAV17780.1 - 8.6e-45 151.7 0.2 1.2e-44 151.2 0.2 1.2 1 0 0 1 1 1 1 FlgO protein FlgT_M PF16539.5 CAV17780.1 - 0.025 14.7 0.0 0.038 14.1 0.0 1.2 1 0 0 1 1 1 0 Flagellar assembly protein T, middle domain Glyco_trans_4_5 PF16994.5 CAV17780.1 - 0.025 14.2 0.0 0.069 12.8 0.0 1.8 2 1 0 2 2 2 0 Glycosyl-transferase family 4 LPP20 PF02169.16 CAV17781.1 - 1e-07 32.2 0.0 1.4e-07 31.8 0.0 1.2 1 0 0 1 1 1 1 LPP20 lipoprotein MLTD_N PF06474.12 CAV17781.1 - 0.039 14.1 0.3 0.079 13.1 0.3 1.5 1 0 0 1 1 1 0 MltD lipid attachment motif TPR_15 PF13429.6 CAV17781.1 - 0.039 13.2 0.0 0.053 12.7 0.0 1.2 1 0 0 1 1 1 0 Tetratricopeptide repeat FlgN PF05130.12 CAV17782.1 - 1.2e-24 87.5 5.6 1.4e-24 87.3 5.6 1.0 1 0 0 1 1 1 1 FlgN protein FlgM PF04316.13 CAV17784.1 - 3.8e-19 68.8 0.4 7.2e-19 67.9 0.4 1.5 1 0 0 1 1 1 1 Anti-sigma-28 factor, FlgM ChapFlgA PF13144.6 CAV17785.1 - 2.1e-33 115.0 4.9 3e-33 114.5 4.9 1.2 1 0 0 1 1 1 1 Chaperone for flagella basal body P-ring formation ChapFlgA_N PF17656.1 CAV17785.1 - 1.1e-15 57.6 0.1 1.8e-15 56.9 0.1 1.4 1 0 0 1 1 1 1 FlgA N-terminal domain SAF PF08666.12 CAV17785.1 - 1.1e-08 35.6 0.0 2.5e-08 34.4 0.0 1.6 1 0 0 1 1 1 1 SAF domain CheW PF01584.19 CAV17786.1 - 1.8e-34 118.3 0.3 6.3e-34 116.6 0.2 1.9 2 0 0 2 2 2 1 CheW-like domain Response_reg PF00072.24 CAV17786.1 - 6.1e-19 68.3 0.1 1.1e-18 67.5 0.1 1.4 1 0 0 1 1 1 1 Response regulator receiver domain LUD_dom PF02589.15 CAV17786.1 - 0.056 13.2 0.0 0.11 12.2 0.0 1.5 1 0 0 1 1 1 0 LUD domain AlphaC_C PF17480.2 CAV17786.1 - 0.13 12.3 2.7 4.1 7.5 0.4 2.4 1 1 1 2 2 2 0 AlphaC C-terminal CheR PF01739.18 CAV17787.1 - 5.1e-68 228.4 0.0 7.3e-68 227.9 0.0 1.2 1 0 0 1 1 1 1 CheR methyltransferase, SAM binding domain CheR_N PF03705.15 CAV17787.1 - 8.1e-10 38.3 0.0 1.2e-09 37.7 0.0 1.3 1 0 0 1 1 1 1 CheR methyltransferase, all-alpha domain Methyltransf_12 PF08242.12 CAV17787.1 - 2.4e-08 34.6 0.0 5.3e-07 30.3 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CAV17787.1 - 2.6e-07 31.3 0.0 0.00048 20.8 0.0 2.4 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_23 PF13489.6 CAV17787.1 - 5.7e-06 26.3 0.0 7.9e-06 25.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CAV17787.1 - 1.3e-05 25.7 0.0 0.00051 20.6 0.0 2.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CAV17787.1 - 0.00025 20.9 0.0 0.00092 19.0 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain TehB PF03848.14 CAV17787.1 - 0.021 14.2 0.0 0.036 13.5 0.0 1.3 1 0 0 1 1 1 0 Tellurite resistance protein TehB TPMT PF05724.11 CAV17787.1 - 0.052 13.2 0.0 0.084 12.5 0.0 1.3 1 0 0 1 1 1 0 Thiopurine S-methyltransferase (TPMT) NNMT_PNMT_TEMT PF01234.17 CAV17787.1 - 0.17 11.1 0.0 0.25 10.5 0.0 1.2 1 0 0 1 1 1 0 NNMT/PNMT/TEMT family Flg_bb_rod PF00460.20 CAV17788.1 - 0.01 15.8 0.0 0.025 14.5 0.0 1.7 1 0 0 1 1 1 0 Flagella basal body rod protein Flg_bbr_C PF06429.13 CAV17789.1 - 1.6e-12 47.4 0.6 3.1e-12 46.4 0.6 1.5 1 0 0 1 1 1 1 Flagellar basal body rod FlgEFG protein C-terminal Flg_bb_rod PF00460.20 CAV17789.1 - 6.8e-08 32.3 1.8 1.9e-07 30.8 1.8 1.8 1 0 0 1 1 1 1 Flagella basal body rod protein FlgD PF03963.14 CAV17791.1 - 2.1e-22 79.2 5.1 4e-22 78.3 5.1 1.5 1 0 0 1 1 1 1 Flagellar hook capping protein - N-terminal region FlgD_ig PF13860.6 CAV17791.1 - 6.4e-20 70.8 0.3 1.3e-19 69.8 0.3 1.5 1 0 0 1 1 1 1 FlgD Ig-like domain FLgD_tudor PF13861.6 CAV17791.1 - 8.1e-16 58.0 1.1 3.4e-15 56.0 0.9 1.9 2 0 0 2 2 2 1 FlgD Tudor-like domain DUF2271 PF10029.9 CAV17791.1 - 0.00044 19.9 0.0 0.00089 18.9 0.0 1.6 1 0 0 1 1 1 1 Predicted periplasmic protein (DUF2271) FlaE PF07559.14 CAV17792.1 - 2.4e-21 76.6 5.5 2.4e-21 76.6 5.5 2.1 2 0 0 2 2 2 1 Flagellar basal body protein FlaE Flg_bbr_C PF06429.13 CAV17792.1 - 1.2e-15 57.4 1.7 2.2e-14 53.4 0.2 2.7 2 0 0 2 2 2 1 Flagellar basal body rod FlgEFG protein C-terminal Flg_bb_rod PF00460.20 CAV17792.1 - 2.3e-10 40.2 2.3 7.9e-10 38.5 2.3 2.0 1 0 0 1 1 1 1 Flagella basal body rod protein Flg_bbr_C PF06429.13 CAV17794.1 - 3.1e-22 78.5 3.1 3.7e-22 78.3 1.3 2.1 2 0 0 2 2 2 1 Flagellar basal body rod FlgEFG protein C-terminal Flg_bb_rod PF00460.20 CAV17794.1 - 6.5e-06 26.0 0.9 1.8e-05 24.5 0.9 1.8 1 0 0 1 1 1 1 Flagella basal body rod protein Big_11 PF18200.1 CAV17794.1 - 0.035 14.0 0.3 1.6 8.7 0.0 2.6 2 1 0 2 2 2 0 Bacterial Ig-like domain Flg_bbr_C PF06429.13 CAV17796.1 - 2.4e-24 85.2 0.7 7.1e-24 83.7 0.7 1.8 1 0 0 1 1 1 1 Flagellar basal body rod FlgEFG protein C-terminal Flg_bb_rod PF00460.20 CAV17796.1 - 9.7e-11 41.4 0.6 9.7e-11 41.4 0.6 1.9 2 0 0 2 2 2 1 Flagella basal body rod protein DUF5006 PF16397.5 CAV17796.1 - 0.017 14.4 0.0 0.04 13.1 0.0 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF5006) DraK_HK_N PF18092.1 CAV17796.1 - 0.036 14.5 1.2 3.1 8.3 0.3 2.7 3 0 0 3 3 3 0 DraK Histidine Kinase N-terminal domain FlgH PF02107.16 CAV17797.1 - 1.8e-56 190.3 0.7 2.3e-56 190.0 0.7 1.1 1 0 0 1 1 1 1 Flagellar L-ring protein FlgI PF02119.16 CAV17798.1 - 1.9e-134 448.0 6.5 2.2e-134 447.8 6.5 1.0 1 0 0 1 1 1 1 Flagellar P-ring protein Glucosaminidase PF01832.20 CAV17800.1 - 1.2e-20 73.8 0.8 2.7e-20 72.6 0.3 1.8 2 0 0 2 2 2 1 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase Rod-binding PF10135.9 CAV17800.1 - 3.4e-14 53.2 8.6 9.6e-14 51.7 7.0 2.5 2 0 0 2 2 2 1 Rod binding protein CDC13_N PF16853.5 CAV17800.1 - 0.017 14.7 1.0 0.029 13.9 1.0 1.4 1 0 0 1 1 1 0 Cell division control protein 13 N-terminus tRNA-synt_2d PF01409.20 CAV17800.1 - 0.042 13.3 0.0 0.064 12.7 0.0 1.3 1 0 0 1 1 1 0 tRNA synthetases class II core domain (F) Flg_bbr_C PF06429.13 CAV17801.1 - 4e-10 39.7 2.4 2e-09 37.5 2.4 2.3 1 0 0 1 1 1 1 Flagellar basal body rod FlgEFG protein C-terminal Flg_bb_rod PF00460.20 CAV17801.1 - 4e-05 23.4 1.7 0.00025 20.9 1.7 2.5 1 0 0 1 1 1 1 Flagella basal body rod protein Flagellin_N PF00669.20 CAV17802.1 - 2.8e-12 46.9 2.0 2.8e-12 46.9 2.0 2.4 2 1 0 2 2 2 1 Bacterial flagellin N-terminal helical region Flagellin_C PF00700.21 CAV17802.1 - 0.00031 21.1 3.0 0.00034 20.9 0.1 2.5 3 0 0 3 3 3 1 Bacterial flagellin C-terminal helical region DUF4105 PF13387.6 CAV17802.1 - 0.04 13.6 0.1 0.1 12.2 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4105) Spectrin PF00435.21 CAV17802.1 - 0.6 10.6 8.8 2.6 8.6 1.2 3.1 2 1 1 3 3 3 0 Spectrin repeat DUF5060 PF16586.5 CAV17802.1 - 1.3 9.5 4.1 16 5.9 0.1 3.6 2 1 1 3 3 3 0 Domain of unknown function (DUF5060) DUF2802 PF10975.8 CAV17802.1 - 9.4 6.5 6.8 5.4 7.2 0.6 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF2802) Flagellin_N PF00669.20 CAV17803.1 - 9.1e-43 145.7 14.6 9.1e-43 145.7 14.6 2.7 2 1 0 2 2 2 1 Bacterial flagellin N-terminal helical region Flagellin_C PF00700.21 CAV17803.1 - 3.8e-26 91.3 8.0 3.8e-26 91.3 8.0 2.6 3 0 0 3 3 3 1 Bacterial flagellin C-terminal helical region Flagellin_IN PF07196.13 CAV17803.1 - 2.3e-10 40.5 2.1 3.9e-10 39.8 0.3 2.5 2 0 0 2 2 2 1 Flagellin hook IN motif BLM10_mid PF16507.5 CAV17803.1 - 0.0041 15.8 0.7 1 8.0 1.5 2.1 2 0 0 2 2 2 2 Proteasome-substrate-size regulator, mid region Vps5 PF09325.10 CAV17803.1 - 0.026 14.1 0.7 0.026 14.1 0.7 2.0 2 0 0 2 2 2 0 Vps5 C terminal like Ntox47 PF15540.6 CAV17803.1 - 0.077 13.3 0.3 0.3 11.4 0.1 2.0 2 0 0 2 2 2 0 Bacterial toxin 47 AAA_lid_9 PF17871.1 CAV17803.1 - 0.14 12.0 5.4 0.99 9.4 1.5 3.3 3 0 0 3 3 3 0 AAA lid domain Med10 PF09748.9 CAV17803.1 - 0.19 11.7 3.3 2.5 8.1 0.0 3.0 3 0 0 3 3 3 0 Transcription factor subunit Med10 of Mediator complex Coq4 PF05019.13 CAV17803.1 - 0.33 10.2 1.6 0.42 9.9 0.4 1.7 2 0 0 2 2 2 0 Coenzyme Q (ubiquinone) biosynthesis protein Coq4 Flagellin_N PF00669.20 CAV17804.1 - 1.8e-41 141.5 18.0 1.8e-41 141.5 18.0 2.7 3 0 0 3 3 3 1 Bacterial flagellin N-terminal helical region Flagellin_C PF00700.21 CAV17804.1 - 4.3e-26 91.1 3.3 4.3e-26 91.1 3.3 2.8 4 1 1 5 5 5 1 Bacterial flagellin C-terminal helical region Flagellin_IN PF07196.13 CAV17804.1 - 6.2e-12 45.5 0.2 6.2e-12 45.5 0.2 4.0 4 0 0 4 4 4 1 Flagellin hook IN motif GLTSCR1 PF15249.6 CAV17804.1 - 0.19 12.2 0.6 0.43 11.0 0.1 1.9 2 0 0 2 2 2 0 Conserved region of unknown function on GLTSCR protein DUF2408 PF10303.9 CAV17804.1 - 0.19 12.3 2.4 8.3 7.0 0.2 2.7 2 2 0 2 2 2 0 Protein of unknown function (DUF2408) Flagellin_N PF00669.20 CAV17805.1 - 1.6e-41 141.6 15.8 1.6e-41 141.6 15.8 2.4 2 0 0 2 2 2 1 Bacterial flagellin N-terminal helical region Flagellin_C PF00700.21 CAV17805.1 - 1.7e-25 89.2 4.4 1.7e-25 89.2 4.4 2.8 2 1 0 2 2 2 1 Bacterial flagellin C-terminal helical region Flagellin_IN PF07196.13 CAV17805.1 - 3.4e-06 27.1 0.0 3.4e-06 27.1 0.0 3.3 5 0 0 5 5 5 1 Flagellin hook IN motif DUF2408 PF10303.9 CAV17805.1 - 0.096 13.2 0.6 1.7 9.2 0.0 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF2408) CBX7_C PF17218.3 CAV17805.1 - 0.11 12.3 1.3 0.2 11.4 1.3 1.4 1 0 0 1 1 1 0 CBX family C-terminal motif GLTSCR1 PF15249.6 CAV17805.1 - 0.15 12.5 0.1 0.15 12.5 0.1 2.4 3 0 0 3 3 3 0 Conserved region of unknown function on GLTSCR protein E2R135 PF11570.8 CAV17805.1 - 0.63 10.3 5.6 1.1 9.5 0.3 2.9 2 2 0 2 2 2 0 Coiled-coil receptor-binding R-domain of colicin E2 NPV_P10 PF05531.12 CAV17805.1 - 1.9 9.0 5.2 14 6.3 0.6 3.5 3 0 0 3 3 3 0 Nucleopolyhedrovirus P10 protein FlaG PF03646.15 CAV17806.1 - 7.6e-23 80.6 2.9 1.1e-22 80.1 2.9 1.2 1 0 0 1 1 1 1 FlaG protein FaeA PF04703.12 CAV17806.1 - 0.15 12.5 0.0 0.29 11.6 0.0 1.5 1 0 0 1 1 1 0 FaeA-like protein FliD_C PF07195.12 CAV17808.1 - 4.5e-49 167.0 1.6 4.5e-49 167.0 1.6 2.3 3 0 0 3 3 3 1 Flagellar hook-associated protein 2 C-terminus FliD_N PF02465.18 CAV17808.1 - 2.2e-20 73.1 1.8 2.2e-20 73.1 1.8 4.5 5 0 0 5 5 5 1 Flagellar hook-associated protein 2 N-terminus Flagellin_IN PF07196.13 CAV17808.1 - 1.9e-09 37.6 0.1 1.9e-09 37.6 0.1 2.7 3 0 0 3 3 3 1 Flagellin hook IN motif OmpH PF03938.14 CAV17808.1 - 4.2 7.7 12.9 0.83 10.0 5.1 3.1 3 0 0 3 3 3 0 Outer membrane protein (OmpH-like) FliT PF05400.13 CAV17809.1 - 0.00011 22.9 1.6 0.00016 22.4 0.3 1.8 1 1 1 2 2 2 1 Flagellar protein FliT F_actin_bind PF08919.10 CAV17809.1 - 0.014 15.5 0.4 0.017 15.2 0.4 1.1 1 0 0 1 1 1 0 F-actin binding FliS PF02561.14 CAV17810.1 - 1.7e-37 128.2 0.0 1.9e-37 128.0 0.0 1.0 1 0 0 1 1 1 1 Flagellar protein FliS DUF4391 PF14335.6 CAV17810.1 - 0.12 12.0 0.1 0.14 11.8 0.1 1.2 1 1 0 1 1 1 0 Domain of unknown function (DUF4391) Sigma54_activat PF00158.26 CAV17811.1 - 3e-73 245.0 0.0 4.2e-73 244.6 0.0 1.2 1 0 0 1 1 1 1 Sigma-54 interaction domain FleQ PF06490.11 CAV17811.1 - 2.9e-32 111.3 0.1 6.6e-32 110.1 0.1 1.7 1 0 0 1 1 1 1 Flagellar regulatory protein FleQ Sigma54_activ_2 PF14532.6 CAV17811.1 - 1.4e-22 80.3 0.0 5.7e-22 78.3 0.0 2.1 2 1 0 2 2 2 1 Sigma-54 interaction domain HTH_8 PF02954.19 CAV17811.1 - 2.7e-14 52.7 0.8 8.9e-14 51.0 0.8 2.0 1 0 0 1 1 1 1 Bacterial regulatory protein, Fis family AAA_5 PF07728.14 CAV17811.1 - 7.8e-08 32.4 0.0 1.6e-07 31.4 0.0 1.5 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA PF00004.29 CAV17811.1 - 2.5e-05 24.7 0.0 5e-05 23.7 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) HTH_50 PF18024.1 CAV17811.1 - 8.3e-05 22.1 0.0 0.00029 20.4 0.0 2.0 1 0 0 1 1 1 1 Helix-turn-helix domain AAA_16 PF13191.6 CAV17811.1 - 0.00017 22.0 0.0 0.00037 20.9 0.0 1.7 1 0 0 1 1 1 1 AAA ATPase domain Mg_chelatase PF01078.21 CAV17811.1 - 0.00026 20.4 0.2 0.22 10.9 0.0 2.2 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_7 PF12775.7 CAV17811.1 - 0.0036 16.8 0.0 0.0061 16.1 0.0 1.3 1 0 0 1 1 1 1 P-loop containing dynein motor region MCM PF00493.23 CAV17811.1 - 0.0087 15.2 0.0 0.037 13.1 0.0 1.8 1 1 0 1 1 1 1 MCM P-loop domain HATPase_c PF02518.26 CAV17812.1 - 3.5e-22 79.0 0.0 8.2e-22 77.8 0.0 1.6 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 CAV17812.1 - 7.2e-10 38.8 0.3 2.5e-09 37.1 0.0 2.1 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain PAS_8 PF13188.7 CAV17812.1 - 2.3e-08 33.9 0.0 4.9e-08 32.8 0.0 1.5 1 0 0 1 1 1 1 PAS domain HATPase_c_2 PF13581.6 CAV17812.1 - 0.00014 21.8 0.0 0.00025 21.0 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-like ATPase domain PAS PF00989.25 CAV17812.1 - 0.00067 19.6 0.0 0.0012 18.8 0.0 1.5 1 0 0 1 1 1 1 PAS fold HATPase_c_5 PF14501.6 CAV17812.1 - 0.0026 17.6 0.0 0.01 15.8 0.0 2.0 2 0 0 2 2 2 1 GHKL domain Endonuc-MspI PF09208.10 CAV17812.1 - 0.0027 17.2 0.1 1.7 8.0 0.0 2.2 2 0 0 2 2 2 2 Restriction endonuclease MspI PAS_4 PF08448.10 CAV17812.1 - 0.0027 17.9 0.0 0.007 16.6 0.0 1.7 1 0 0 1 1 1 1 PAS fold HATPase_c_3 PF13589.6 CAV17812.1 - 0.061 13.2 0.0 0.11 12.3 0.0 1.4 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase GAPES3 PF17154.4 CAV17812.1 - 0.072 13.1 0.3 2.3 8.2 0.1 2.5 2 0 0 2 2 2 0 Gammaproteobacterial periplasmic sensor domain PAS_9 PF13426.7 CAV17812.1 - 0.13 12.6 0.0 0.29 11.4 0.0 1.7 1 0 0 1 1 1 0 PAS domain Sigma54_activat PF00158.26 CAV17813.1 - 3.5e-65 218.8 0.0 5.7e-65 218.1 0.0 1.4 1 0 0 1 1 1 1 Sigma-54 interaction domain Response_reg PF00072.24 CAV17813.1 - 9.4e-28 96.6 0.1 1.9e-27 95.7 0.1 1.5 1 0 0 1 1 1 1 Response regulator receiver domain Sigma54_activ_2 PF14532.6 CAV17813.1 - 2.6e-20 73.0 0.0 1.5e-19 70.5 0.0 2.1 1 1 0 1 1 1 1 Sigma-54 interaction domain HTH_8 PF02954.19 CAV17813.1 - 7.5e-13 48.0 0.3 2.1e-12 46.6 0.3 1.8 1 0 0 1 1 1 1 Bacterial regulatory protein, Fis family AAA_5 PF07728.14 CAV17813.1 - 1.4e-07 31.6 0.0 4.4e-07 30.0 0.0 1.9 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) HTH_30 PF13556.6 CAV17813.1 - 5.3e-06 26.1 0.0 1.2e-05 25.0 0.0 1.6 1 0 0 1 1 1 1 PucR C-terminal helix-turn-helix domain HTH_28 PF13518.6 CAV17813.1 - 0.00051 20.1 0.0 0.0012 18.9 0.0 1.6 1 0 0 1 1 1 1 Helix-turn-helix domain Mg_chelatase PF01078.21 CAV17813.1 - 0.00093 18.6 0.1 0.27 10.6 0.0 2.2 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_2 PF07724.14 CAV17813.1 - 0.0012 19.0 0.0 0.0033 17.6 0.0 1.7 1 1 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_7 PF12775.7 CAV17813.1 - 0.0022 17.6 0.0 0.0034 16.9 0.0 1.2 1 0 0 1 1 1 1 P-loop containing dynein motor region FleQ PF06490.11 CAV17813.1 - 0.0023 18.3 0.0 0.007 16.7 0.0 1.9 2 0 0 2 2 1 1 Flagellar regulatory protein FleQ DUF2089 PF09862.9 CAV17813.1 - 0.0023 17.9 0.0 0.0051 16.8 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF2089) AAA PF00004.29 CAV17813.1 - 0.0038 17.7 0.0 0.0071 16.8 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) MCM PF00493.23 CAV17813.1 - 0.005 16.0 0.0 0.0094 15.1 0.0 1.4 1 0 0 1 1 1 1 MCM P-loop domain HTH_24 PF13412.6 CAV17813.1 - 0.0067 16.0 0.0 0.018 14.6 0.0 1.7 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding MerR PF00376.23 CAV17813.1 - 0.012 15.4 0.0 0.023 14.5 0.0 1.4 1 0 0 1 1 1 0 MerR family regulatory protein HTH_11 PF08279.12 CAV17813.1 - 0.012 15.5 0.1 0.041 13.8 0.0 1.9 2 0 0 2 2 2 0 HTH domain AAA_3 PF07726.11 CAV17813.1 - 0.017 15.0 0.0 0.034 14.0 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) HTH_5 PF01022.20 CAV17813.1 - 0.047 13.6 0.0 0.15 11.9 0.0 1.8 2 0 0 2 2 2 0 Bacterial regulatory protein, arsR family AAA_16 PF13191.6 CAV17813.1 - 0.048 14.1 0.0 0.24 11.7 0.0 2.1 1 1 0 1 1 1 0 AAA ATPase domain HTH_20 PF12840.7 CAV17813.1 - 0.053 13.6 0.0 0.13 12.4 0.0 1.7 1 0 0 1 1 1 0 Helix-turn-helix domain AAA_19 PF13245.6 CAV17813.1 - 0.06 13.7 0.5 1.7 9.0 0.3 2.7 2 1 0 2 2 2 0 AAA domain HTH_Crp_2 PF13545.6 CAV17813.1 - 0.061 13.3 0.0 0.21 11.6 0.0 1.9 1 0 0 1 1 1 0 Crp-like helix-turn-helix domain HTH_Mga PF08280.11 CAV17813.1 - 0.065 13.3 0.2 4.9 7.2 0.0 2.8 3 0 0 3 3 3 0 M protein trans-acting positive regulator (MGA) HTH domain AAA_32 PF13654.6 CAV17813.1 - 0.072 11.9 0.0 0.8 8.4 0.0 2.0 2 0 0 2 2 2 0 AAA domain HTH_10 PF04967.12 CAV17813.1 - 0.1 12.4 0.0 0.25 11.2 0.0 1.6 1 0 0 1 1 1 0 HTH DNA binding domain FliE PF02049.18 CAV17814.1 - 7.6e-29 99.7 2.1 9.2e-29 99.4 2.1 1.1 1 0 0 1 1 1 1 Flagellar hook-basal body complex protein FliE YscJ_FliF PF01514.17 CAV17815.1 - 5.9e-55 186.0 2.7 9.7e-55 185.2 0.8 2.2 2 0 0 2 2 2 1 Secretory protein of YscJ/FliF family YscJ_FliF_C PF08345.11 CAV17815.1 - 1.8e-38 132.2 4.0 4.6e-38 130.9 0.3 2.4 2 0 0 2 2 2 1 Flagellar M-ring protein C-terminal SasG_E PF17041.5 CAV17815.1 - 0.033 14.2 0.3 1.1 9.3 0.1 2.6 2 0 0 2 2 2 0 E domain DUF3619 PF12279.8 CAV17815.1 - 0.1 12.9 3.2 32 4.8 0.6 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF3619) DUF2798 PF11391.8 CAV17815.1 - 6.1 7.0 8.2 0.49 10.5 1.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2798) FliG_C PF01706.16 CAV17816.1 - 4.8e-42 142.5 13.4 1.2e-40 138.1 4.6 3.2 3 0 0 3 3 3 2 FliG C-terminal domain FliG_N PF14842.6 CAV17816.1 - 2.5e-35 121.2 11.4 8.5e-27 93.7 0.1 3.6 2 1 2 4 4 4 2 FliG N-terminal domain FliG_M PF14841.6 CAV17816.1 - 6.2e-30 103.3 9.0 5.1e-26 90.7 2.1 3.5 4 0 0 4 4 4 2 FliG middle domain MgtE_N PF03448.17 CAV17816.1 - 4.8e-09 36.7 11.3 0.072 13.7 0.7 4.7 3 1 2 5 5 5 3 MgtE intracellular N domain Glu-tRNAGln PF02686.15 CAV17816.1 - 0.029 14.7 3.1 0.37 11.1 3.1 2.8 1 1 0 1 1 1 0 Glu-tRNAGln amidotransferase C subunit FliH PF02108.16 CAV17817.1 - 3.7e-35 120.8 1.0 5.5e-35 120.2 1.0 1.2 1 0 0 1 1 1 1 Flagellar assembly protein FliH Yae1_N PF09811.9 CAV17817.1 - 0.00049 19.7 15.9 0.00085 19.0 14.1 2.1 1 1 1 2 2 2 1 Essential protein Yae1, N terminal ATP-synt_ab PF00006.25 CAV17818.1 - 5.7e-74 248.4 0.0 7.4e-74 248.0 0.0 1.1 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain T3SS_ATPase_C PF18269.1 CAV17818.1 - 2.1e-22 78.7 0.0 3.3e-22 78.1 0.0 1.3 1 0 0 1 1 1 1 T3SS EscN ATPase C-terminal domain FliJ PF02050.16 CAV17820.1 - 8.6e-29 100.3 19.6 1.1e-28 99.9 19.6 1.2 1 0 0 1 1 1 1 Flagellar FliJ protein YscO-like PF16789.5 CAV17820.1 - 0.00042 20.4 13.3 0.00062 19.8 13.3 1.2 1 0 0 1 1 1 1 YscO-like protein WD-3 PF09765.9 CAV17820.1 - 0.017 14.5 5.5 0.021 14.2 5.5 1.1 1 0 0 1 1 1 0 WD-repeat region DUF4239 PF14023.6 CAV17820.1 - 0.094 12.4 0.4 0.13 12.0 0.2 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF4239) UPF0242 PF06785.11 CAV17820.1 - 0.26 11.4 19.1 0.85 9.7 10.2 2.0 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus YscO PF07321.12 CAV17820.1 - 0.29 11.1 17.4 0.52 10.3 8.6 2.0 1 1 1 2 2 2 0 Type III secretion protein YscO Flg_hook PF02120.16 CAV17821.1 - 1.3e-22 79.5 5.3 1.3e-22 79.5 5.3 4.3 4 0 0 4 4 4 1 Flagellar hook-length control protein FliK TolA_bind_tri PF16331.5 CAV17821.1 - 0.024 14.7 1.8 0.024 14.7 1.8 4.5 3 1 0 4 4 4 0 TolA binding protein trimerisation TRAF_BIRC3_bd PF16673.5 CAV17821.1 - 0.13 12.1 1.6 12 5.8 0.0 2.9 2 0 0 2 2 2 0 TNF receptor-associated factor BIRC3 binding domain FliL PF03748.14 CAV17823.1 - 7.2e-19 68.3 0.3 1.1e-18 67.7 0.3 1.3 1 0 0 1 1 1 1 Flagellar basal body-associated protein FliL DUF4366 PF14283.6 CAV17823.1 - 0.045 13.8 0.1 0.072 13.1 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4366) CbiN PF02553.15 CAV17823.1 - 0.088 12.8 0.3 0.23 11.5 0.3 1.7 1 0 0 1 1 1 0 Cobalt transport protein component CbiN FliM PF02154.15 CAV17824.1 - 1.7e-83 279.2 0.6 2.3e-83 278.8 0.6 1.2 1 0 0 1 1 1 1 Flagellar motor switch protein FliM FliMN_C PF01052.20 CAV17824.1 - 1.9e-18 66.2 0.1 4.2e-18 65.1 0.1 1.6 1 0 0 1 1 1 1 Type III flagellar switch regulator (C-ring) FliN C-term FliMN_C PF01052.20 CAV17825.1 - 1.4e-24 85.8 1.4 2e-24 85.3 1.4 1.2 1 0 0 1 1 1 1 Type III flagellar switch regulator (C-ring) FliN C-term FliO PF04347.13 CAV17827.1 - 9.8e-17 61.0 0.2 1.4e-16 60.6 0.2 1.2 1 0 0 1 1 1 1 Flagellar biosynthesis protein, FliO GPDPase_memb PF10110.9 CAV17827.1 - 0.0063 15.3 0.3 0.009 14.8 0.3 1.2 1 0 0 1 1 1 1 Membrane domain of glycerophosphoryl diester phosphodiesterase FixQ PF05545.11 CAV17827.1 - 0.29 11.2 2.3 0.48 10.4 2.3 1.3 1 0 0 1 1 1 0 Cbb3-type cytochrome oxidase component FixQ FliP PF00813.20 CAV17828.1 - 1.1e-78 263.5 22.7 1.7e-78 262.9 22.7 1.3 1 0 0 1 1 1 1 FliP family Bac_export_3 PF01313.19 CAV17830.1 - 9.1e-27 92.8 13.8 1e-26 92.6 13.8 1.0 1 0 0 1 1 1 1 Bacterial export proteins, family 3 ALG3 PF05208.13 CAV17830.1 - 0.084 12.3 6.4 0.093 12.1 6.4 1.0 1 0 0 1 1 1 0 ALG3 protein FtsX PF02687.21 CAV17830.1 - 1.4 9.5 9.3 3.6 8.1 9.3 1.7 1 1 0 1 1 1 0 FtsX-like permease family Bac_export_1 PF01311.20 CAV17831.1 - 2.1e-57 194.3 29.5 2.6e-57 194.0 29.5 1.0 1 0 0 1 1 1 1 Bacterial export proteins, family 1 Bac_export_2 PF01312.19 CAV17833.1 - 9.6e-122 406.3 7.3 1.1e-121 406.1 7.3 1.0 1 0 0 1 1 1 1 FlhB HrpN YscU SpaS Family FHIPEP PF00771.20 CAV17834.1 - 1.8e-268 892.5 6.9 2.1e-268 892.2 6.9 1.0 1 0 0 1 1 1 1 FHIPEP family DUF3384 PF11864.8 CAV17834.1 - 0.14 11.0 0.1 0.21 10.4 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3384) SRP54 PF00448.22 CAV17836.1 - 4.1e-39 134.3 0.0 7e-39 133.5 0.0 1.3 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain AAA_22 PF13401.6 CAV17836.1 - 0.00037 20.8 0.5 0.0016 18.7 0.0 2.3 3 0 0 3 3 3 1 AAA domain AAA_30 PF13604.6 CAV17836.1 - 0.00038 20.2 0.6 0.00071 19.3 0.6 1.4 1 0 0 1 1 1 1 AAA domain NACHT PF05729.12 CAV17836.1 - 0.00063 19.7 0.0 0.0015 18.5 0.0 1.6 1 0 0 1 1 1 1 NACHT domain FtsK_SpoIIIE PF01580.18 CAV17836.1 - 0.00068 19.1 0.3 0.017 14.5 0.1 2.3 2 0 0 2 2 2 1 FtsK/SpoIIIE family MMR_HSR1 PF01926.23 CAV17836.1 - 0.00079 19.5 0.0 0.002 18.2 0.0 1.7 1 1 0 1 1 1 1 50S ribosome-binding GTPase ABC_tran PF00005.27 CAV17836.1 - 0.0011 19.5 0.1 0.0011 19.5 0.1 2.4 2 2 0 2 2 2 1 ABC transporter CbiA PF01656.23 CAV17836.1 - 0.0022 18.0 0.0 0.011 15.8 0.0 2.2 2 1 0 2 2 2 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_16 PF13191.6 CAV17836.1 - 0.0033 17.8 1.4 0.006 17.0 0.0 2.2 2 1 0 2 2 2 1 AAA ATPase domain AAA PF00004.29 CAV17836.1 - 0.0051 17.2 0.1 0.015 15.8 0.1 1.9 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_28 PF13521.6 CAV17836.1 - 0.0056 16.9 0.0 0.014 15.7 0.0 1.7 1 0 0 1 1 1 1 AAA domain DUF87 PF01935.17 CAV17836.1 - 0.0073 16.4 4.8 0.031 14.4 0.1 3.1 4 0 0 4 4 4 1 Helicase HerA, central domain AAA_25 PF13481.6 CAV17836.1 - 0.0073 15.9 3.2 0.01 15.5 0.8 2.2 2 1 1 3 3 3 1 AAA domain RsgA_GTPase PF03193.16 CAV17836.1 - 0.012 15.5 0.1 0.066 13.1 0.1 2.1 1 1 1 2 2 2 0 RsgA GTPase ATPase PF06745.13 CAV17836.1 - 0.013 14.9 0.0 0.026 13.9 0.0 1.5 1 0 0 1 1 1 0 KaiC AAA_33 PF13671.6 CAV17836.1 - 0.015 15.4 0.0 0.046 13.9 0.0 1.9 1 0 0 1 1 1 0 AAA domain ResIII PF04851.15 CAV17836.1 - 0.017 15.1 0.1 0.047 13.7 0.1 1.7 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit Flavodoxin_3 PF12641.7 CAV17836.1 - 0.033 13.9 0.0 0.073 12.8 0.0 1.5 1 0 0 1 1 1 0 Flavodoxin domain IstB_IS21 PF01695.17 CAV17836.1 - 0.049 13.4 1.1 0.41 10.4 1.0 2.1 1 1 0 1 1 1 0 IstB-like ATP binding protein AAA_18 PF13238.6 CAV17836.1 - 0.076 13.6 0.0 0.21 12.1 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 CAV17836.1 - 0.096 12.2 0.1 0.19 11.2 0.1 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region RNA_helicase PF00910.22 CAV17836.1 - 0.12 12.7 0.0 0.52 10.7 0.0 2.1 2 0 0 2 2 2 0 RNA helicase AAA_14 PF13173.6 CAV17836.1 - 0.13 12.4 0.0 0.29 11.2 0.0 1.7 1 0 0 1 1 1 0 AAA domain TsaE PF02367.17 CAV17836.1 - 0.13 12.2 0.7 0.4 10.7 0.7 1.8 1 1 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_19 PF13245.6 CAV17836.1 - 0.22 11.9 0.9 0.55 10.6 0.9 1.7 1 1 0 1 1 1 0 AAA domain ParA PF10609.9 CAV17838.1 - 1.5e-22 80.3 4.7 4.6e-22 78.7 4.7 1.7 1 1 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase AAA_31 PF13614.6 CAV17838.1 - 2.1e-18 66.8 0.1 3e-18 66.4 0.1 1.2 1 0 0 1 1 1 1 AAA domain CbiA PF01656.23 CAV17838.1 - 2.3e-18 66.5 0.2 3.1e-18 66.1 0.2 1.2 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain Fer4_NifH PF00142.18 CAV17838.1 - 1.1e-11 44.7 1.0 2.3e-11 43.7 1.0 1.4 1 1 0 1 1 1 1 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family MipZ PF09140.11 CAV17838.1 - 1.4e-09 37.6 0.6 2.9e-09 36.6 0.6 1.5 1 1 0 1 1 1 1 ATPase MipZ CBP_BcsQ PF06564.12 CAV17838.1 - 2e-09 37.3 0.0 2.4e-09 37.0 0.0 1.3 1 1 0 1 1 1 1 Cellulose biosynthesis protein BcsQ ArsA_ATPase PF02374.15 CAV17838.1 - 1.4e-05 24.4 3.1 3.2e-05 23.3 1.6 2.0 2 0 0 2 2 2 1 Anion-transporting ATPase AAA_26 PF13500.6 CAV17838.1 - 3e-05 23.9 2.0 0.0084 16.0 0.0 2.5 2 1 0 2 2 2 2 AAA domain AAA_25 PF13481.6 CAV17838.1 - 0.0033 17.0 0.1 0.0075 15.9 0.1 1.6 1 0 0 1 1 1 1 AAA domain MeaB PF03308.16 CAV17838.1 - 0.028 13.4 0.2 0.056 12.4 0.2 1.4 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB CLP1_P PF16575.5 CAV17838.1 - 0.19 11.5 0.6 0.38 10.5 0.1 1.7 2 1 1 3 3 3 0 mRNA cleavage and polyadenylation factor CLP1 P-loop Sigma70_r4 PF04545.16 CAV17839.1 - 9.8e-19 66.6 0.5 2.4e-17 62.2 0.8 2.4 2 0 0 2 2 2 1 Sigma-70, region 4 Sigma70_r2 PF04542.14 CAV17839.1 - 1.8e-15 56.4 0.0 3.1e-15 55.7 0.0 1.4 1 0 0 1 1 1 1 Sigma-70 region 2 Sigma70_r3 PF04539.16 CAV17839.1 - 3.5e-14 52.7 0.2 2.8e-11 43.4 0.0 2.3 2 0 0 2 2 2 2 Sigma-70 region 3 Sigma70_r4_2 PF08281.12 CAV17839.1 - 5.3e-09 35.6 1.3 4.1e-08 32.8 0.4 2.6 3 0 0 3 3 3 1 Sigma-70, region 4 HTH_10 PF04967.12 CAV17839.1 - 0.00039 20.1 0.0 0.019 14.7 0.0 2.6 2 0 0 2 2 2 1 HTH DNA binding domain HTH_23 PF13384.6 CAV17839.1 - 0.0011 18.6 0.0 0.016 15.0 0.0 2.3 2 0 0 2 2 2 1 Homeodomain-like domain UPF0122 PF04297.14 CAV17839.1 - 0.0013 18.9 0.0 0.0053 17.0 0.0 2.0 1 1 0 1 1 1 1 Putative helix-turn-helix protein, YlxM / p13 like GerE PF00196.19 CAV17839.1 - 0.0089 15.6 0.1 0.023 14.2 0.1 1.7 2 0 0 2 2 2 1 Bacterial regulatory proteins, luxR family Frankia_peptide PF14407.6 CAV17839.1 - 0.012 15.6 0.1 0.038 14.0 0.0 1.9 2 0 0 2 2 2 0 Ribosomally synthesized peptide prototyped by Frankia Franean1_4349. MarR_2 PF12802.7 CAV17839.1 - 0.051 13.5 0.0 0.24 11.3 0.0 2.1 2 0 0 2 2 2 0 MarR family HTH_Mga PF08280.11 CAV17839.1 - 0.053 13.5 0.6 0.38 10.8 0.0 2.5 3 0 0 3 3 3 0 M protein trans-acting positive regulator (MGA) HTH domain HTH_24 PF13412.6 CAV17839.1 - 0.07 12.7 0.2 0.71 9.5 0.0 2.5 3 0 0 3 3 3 0 Winged helix-turn-helix DNA-binding UPF0175 PF03683.13 CAV17839.1 - 0.085 12.6 0.1 0.35 10.6 0.1 1.9 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0175) HTH_31 PF13560.6 CAV17839.1 - 0.12 12.7 0.0 7 7.1 0.0 2.4 2 0 0 2 2 2 0 Helix-turn-helix domain HTH_28 PF13518.6 CAV17839.1 - 0.14 12.3 0.0 1.9 8.7 0.0 2.4 2 0 0 2 2 2 0 Helix-turn-helix domain Response_reg PF00072.24 CAV17840.1 - 1.4e-31 108.9 0.2 1.6e-31 108.8 0.2 1.0 1 0 0 1 1 1 1 Response regulator receiver domain Glycos_transf_1 PF00534.20 CAV17840.1 - 0.062 12.8 0.0 0.093 12.3 0.0 1.2 1 0 0 1 1 1 0 Glycosyl transferases group 1 FleQ PF06490.11 CAV17840.1 - 0.085 13.2 0.0 0.13 12.6 0.0 1.3 1 1 0 1 1 1 0 Flagellar regulatory protein FleQ OpuAC PF04069.12 CAV17840.1 - 0.1 12.1 0.0 0.11 12.1 0.0 1.1 1 0 0 1 1 1 0 Substrate binding domain of ABC-type glycine betaine transport system CheZ PF04344.13 CAV17841.1 - 3.4e-75 252.4 0.3 3.8e-75 252.2 0.3 1.0 1 0 0 1 1 1 1 Chemotaxis phosphatase, CheZ CheW PF01584.19 CAV17843.1 - 2.9e-22 78.8 0.3 4.7e-22 78.1 0.3 1.3 1 0 0 1 1 1 1 CheW-like domain HATPase_c PF02518.26 CAV17843.1 - 3.4e-18 66.2 0.1 8.6e-18 64.9 0.1 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Hpt PF01627.23 CAV17843.1 - 1.3e-17 63.8 0.8 3.9e-17 62.3 0.1 2.2 2 0 0 2 2 2 1 Hpt domain H-kinase_dim PF02895.14 CAV17843.1 - 2.8e-12 46.8 4.6 2.9e-12 46.8 2.5 2.2 2 0 0 2 2 2 1 Signal transducing histidine kinase, homodimeric domain SHOCT PF09851.9 CAV17843.1 - 0.00016 21.3 6.4 0.064 13.0 0.2 3.5 3 0 0 3 3 3 2 Short C-terminal domain HATPase_c_3 PF13589.6 CAV17843.1 - 0.0021 17.9 0.2 0.0062 16.4 0.2 1.8 1 1 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DUF1018 PF06252.12 CAV17843.1 - 0.0026 18.7 0.0 4.2 8.4 0.0 3.3 1 1 1 2 2 2 2 Protein of unknown function (DUF1018) Arteri_nsp7a PF16749.5 CAV17843.1 - 0.095 12.9 0.2 0.23 11.7 0.2 1.5 1 0 0 1 1 1 0 Arterivirus nonstructural protein 7 alpha CheB_methylest PF01339.17 CAV17844.1 - 6.5e-58 195.2 0.2 4.1e-57 192.6 0.0 2.1 2 1 0 2 2 2 1 CheB methylesterase Response_reg PF00072.24 CAV17844.1 - 6.5e-24 84.3 0.2 1.3e-23 83.3 0.2 1.5 1 0 0 1 1 1 1 Response regulator receiver domain DXP_reductoisom PF02670.16 CAV17844.1 - 0.039 14.7 0.0 0.096 13.4 0.0 1.6 1 0 0 1 1 1 0 1-deoxy-D-xylulose 5-phosphate reductoisomerase AAA_31 PF13614.6 CAV17845.1 - 1.2e-51 175.1 0.0 1.6e-51 174.7 0.0 1.1 1 0 0 1 1 1 1 AAA domain CbiA PF01656.23 CAV17845.1 - 1.8e-21 76.5 0.0 2.3e-21 76.2 0.0 1.1 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain MipZ PF09140.11 CAV17845.1 - 7.4e-12 45.1 0.1 2.4e-06 27.0 0.0 2.1 1 1 1 2 2 2 2 ATPase MipZ CBP_BcsQ PF06564.12 CAV17845.1 - 2.9e-11 43.3 0.0 4.3e-11 42.7 0.0 1.3 1 0 0 1 1 1 1 Cellulose biosynthesis protein BcsQ ParA PF10609.9 CAV17845.1 - 3.1e-09 36.6 0.9 7.2e-09 35.5 0.9 1.7 1 1 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase ArsA_ATPase PF02374.15 CAV17845.1 - 2.5e-08 33.5 1.1 9.1e-08 31.6 1.1 2.0 1 1 0 1 1 1 1 Anion-transporting ATPase Fer4_NifH PF00142.18 CAV17845.1 - 3e-07 30.2 0.0 7.9e-07 28.8 0.0 1.5 1 1 0 1 1 1 1 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family VirC1 PF07015.11 CAV17845.1 - 1.7e-05 24.2 0.0 0.00035 20.0 0.0 2.1 2 0 0 2 2 2 1 VirC1 protein ATP_bind_1 PF03029.17 CAV17845.1 - 0.0069 16.2 0.1 0.031 14.1 0.1 2.0 1 1 0 1 1 1 1 Conserved hypothetical ATP binding protein CLP1_P PF16575.5 CAV17845.1 - 0.01 15.6 0.1 0.024 14.4 0.1 1.6 1 0 0 1 1 1 0 mRNA cleavage and polyadenylation factor CLP1 P-loop SRP54 PF00448.22 CAV17845.1 - 0.019 14.6 0.5 0.078 12.6 0.3 1.9 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain CheW PF01584.19 CAV17846.1 - 5e-14 52.1 0.0 1e-13 51.1 0.0 1.6 1 0 0 1 1 1 1 CheW-like domain Trypan_PARP PF05887.11 CAV17846.1 - 3.4e-09 36.8 33.8 3.4e-09 36.8 33.8 2.3 2 0 0 2 2 2 1 Procyclic acidic repetitive protein (PARP) TonB_N PF16031.5 CAV17846.1 - 0.00044 20.8 32.7 0.0015 19.1 28.5 2.3 2 0 0 2 2 2 1 TonB polyproline region NESP55 PF06390.12 CAV17846.1 - 1.8 8.1 24.9 0.22 11.1 14.7 2.2 2 0 0 2 2 2 0 Neuroendocrine-specific golgi protein P55 (NESP55) CheW PF01584.19 CAV17848.1 - 2.7e-40 137.2 1.3 3.1e-40 137.0 1.3 1.0 1 0 0 1 1 1 1 CheW-like domain DUF2802 PF10975.8 CAV17849.1 - 6.2e-22 77.5 1.1 6.2e-22 77.5 1.1 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF2802) LMBR1 PF04791.16 CAV17849.1 - 0.0029 16.6 0.1 0.0033 16.4 0.1 1.0 1 0 0 1 1 1 1 LMBR1-like membrane protein LapA_dom PF06305.11 CAV17849.1 - 0.0084 15.9 0.5 0.028 14.2 0.2 1.9 2 0 0 2 2 2 1 Lipopolysaccharide assembly protein A domain TMF_DNA_bd PF12329.8 CAV17849.1 - 0.012 15.5 3.8 0.012 15.5 3.8 2.1 2 1 1 3 3 3 0 TATA element modulatory factor 1 DNA binding Spc29 PF17082.5 CAV17849.1 - 0.017 15.0 0.6 0.025 14.4 0.6 1.3 1 0 0 1 1 1 0 Spindle Pole Component 29 DUF745 PF05335.13 CAV17849.1 - 0.052 13.3 1.3 0.082 12.6 1.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF745) Sec8_exocyst PF04048.14 CAV17849.1 - 0.14 12.0 3.0 0.23 11.3 3.0 1.2 1 0 0 1 1 1 0 Sec8 exocyst complex component specific domain ABC_tran_CTD PF16326.5 CAV17849.1 - 0.15 12.3 2.1 0.41 10.9 0.1 2.4 2 1 0 2 2 2 0 ABC transporter C-terminal domain DUF948 PF06103.11 CAV17849.1 - 0.35 11.2 3.1 0.36 11.1 2.0 1.7 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) SlyX PF04102.12 CAV17849.1 - 0.35 11.5 7.7 3.9 8.1 0.5 2.6 1 1 1 2 2 2 0 SlyX DUF1664 PF07889.12 CAV17849.1 - 0.69 10.0 4.7 1.3 9.1 4.7 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) ABC_tran PF00005.27 CAV17851.1 - 1.3e-30 106.7 0.0 1.7e-30 106.3 0.0 1.1 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 CAV17851.1 - 4.5e-07 30.0 0.3 0.00046 20.1 0.1 2.1 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 CAV17851.1 - 1.2e-05 24.9 0.0 0.0012 18.3 0.0 2.1 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_30 PF13604.6 CAV17851.1 - 0.0046 16.7 0.2 0.01 15.6 0.2 1.6 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.6 CAV17851.1 - 0.0057 16.9 0.1 0.012 15.9 0.1 1.7 1 1 0 1 1 1 1 AAA domain DUF3584 PF12128.8 CAV17851.1 - 0.0089 13.6 0.1 0.012 13.2 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3584) AAA_13 PF13166.6 CAV17851.1 - 0.018 13.7 0.1 0.023 13.4 0.1 1.1 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 CAV17851.1 - 0.029 14.3 0.1 0.13 12.2 0.0 1.9 2 0 0 2 2 2 0 NACHT domain NB-ARC PF00931.22 CAV17851.1 - 0.033 13.4 0.2 0.24 10.5 0.2 2.0 1 1 0 1 1 1 0 NB-ARC domain AAA_23 PF13476.6 CAV17851.1 - 0.039 14.5 0.2 0.051 14.1 0.2 1.4 1 1 0 1 1 1 0 AAA domain AAA_15 PF13175.6 CAV17851.1 - 0.045 13.4 0.0 0.29 10.8 0.0 1.9 1 1 1 2 2 2 0 AAA ATPase domain CcmB PF03379.13 CAV17852.1 - 4.5e-89 297.6 26.4 5.1e-89 297.4 26.4 1.0 1 0 0 1 1 1 1 CcmB protein ABC2_membrane_4 PF12730.7 CAV17852.1 - 0.57 10.1 14.1 0.79 9.7 11.7 2.4 1 1 0 1 1 1 0 ABC-2 family transporter protein ABC2_membrane_3 PF12698.7 CAV17852.1 - 1.2 8.2 25.1 0.095 11.8 18.5 2.2 1 1 2 3 3 3 0 ABC-2 family transporter protein Cytochrom_C_asm PF01578.20 CAV17854.1 - 4e-32 111.7 22.4 4e-32 111.7 22.4 1.7 2 0 0 2 2 2 1 Cytochrome C assembly protein CcmD PF04995.14 CAV17855.1 - 6.8e-18 64.5 0.5 8.1e-18 64.2 0.5 1.1 1 0 0 1 1 1 1 Heme exporter protein D (CcmD) Phage_holin_3_6 PF07332.11 CAV17855.1 - 0.014 15.4 0.0 0.015 15.3 0.0 1.1 1 0 0 1 1 1 0 Putative Actinobacterial Holin-X, holin superfamily III DUF3169 PF11368.8 CAV17855.1 - 0.017 14.6 0.0 0.018 14.6 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3169) CcmE PF03100.15 CAV17857.1 - 1.6e-43 147.8 0.0 1.9e-43 147.5 0.0 1.1 1 0 0 1 1 1 1 CcmE Dimerisation PF08100.11 CAV17857.1 - 0.093 12.8 0.0 0.45 10.6 0.0 1.9 2 0 0 2 2 2 0 Dimerisation domain TolB_N PF04052.13 CAV17857.1 - 0.16 12.1 0.0 0.31 11.2 0.0 1.4 1 0 0 1 1 1 0 TolB amino-terminal domain CcmF_C PF16327.5 CAV17858.1 - 6.7e-126 419.9 4.0 6.7e-126 419.9 4.0 1.9 2 0 0 2 2 2 1 Cytochrome c-type biogenesis protein CcmF C-terminal Cytochrom_C_asm PF01578.20 CAV17858.1 - 6.8e-54 182.9 20.5 6.8e-54 182.9 20.5 3.0 3 0 0 3 3 3 1 Cytochrome C assembly protein ResB PF05140.14 CAV17858.1 - 0.028 13.2 3.8 0.14 10.8 0.0 2.7 2 1 0 3 3 3 0 ResB-like family RAMP4 PF06624.12 CAV17858.1 - 3 8.0 7.0 3.7 7.7 2.2 2.5 2 0 0 2 2 2 0 Ribosome associated membrane protein RAMP4 Redoxin PF08534.10 CAV17860.1 - 1.3e-25 89.9 0.0 1.6e-25 89.5 0.0 1.1 1 0 0 1 1 1 1 Redoxin AhpC-TSA PF00578.21 CAV17860.1 - 1.3e-14 54.2 0.0 1.7e-14 53.8 0.0 1.1 1 0 0 1 1 1 1 AhpC/TSA family Thioredoxin_2 PF13098.6 CAV17860.1 - 0.0001 22.7 0.0 0.00018 21.9 0.0 1.4 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_8 PF13905.6 CAV17860.1 - 0.0023 18.2 0.0 0.0045 17.3 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin-like Thioredoxin PF00085.20 CAV17860.1 - 0.0041 17.1 0.0 0.013 15.5 0.0 1.8 2 1 1 3 3 3 1 Thioredoxin CcmH PF03918.14 CAV17861.1 - 2.7e-51 172.6 0.0 3.2e-51 172.4 0.0 1.0 1 0 0 1 1 1 1 Cytochrome C biogenesis protein DUF3797 PF12677.7 CAV17861.1 - 0.0041 17.0 0.1 0.0068 16.3 0.1 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3797) ATP1G1_PLM_MAT8 PF02038.16 CAV17861.1 - 0.047 13.1 0.3 0.2 11.1 0.0 2.0 2 0 0 2 2 2 0 ATP1G1/PLM/MAT8 family TPR_19 PF14559.6 CAV17862.1 - 4.2e-05 24.0 3.8 0.00022 21.6 3.8 2.3 1 1 0 1 1 1 1 Tetratricopeptide repeat TPR_2 PF07719.17 CAV17862.1 - 0.00012 21.9 0.2 0.023 14.8 0.0 3.1 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.6 CAV17862.1 - 0.00038 21.0 0.3 0.0014 19.3 0.3 2.0 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_8 PF13181.6 CAV17862.1 - 0.0031 17.6 0.1 0.011 15.9 0.0 2.0 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_16 PF13432.6 CAV17862.1 - 0.0059 17.2 1.5 0.022 15.4 0.7 2.2 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_17 PF13431.6 CAV17862.1 - 0.081 13.3 0.3 3 8.4 0.0 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_6 PF13174.6 CAV17862.1 - 0.25 12.0 1.6 17 6.3 0.1 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat MlaA PF04333.13 CAV17863.1 - 7e-63 211.9 0.0 8.3e-63 211.6 0.0 1.1 1 0 0 1 1 1 1 MlaA lipoprotein Toluene_X PF03349.16 CAV17864.1 - 4.2e-126 421.0 15.0 5.5e-126 420.6 15.0 1.1 1 0 0 1 1 1 1 Outer membrane protein transport protein (OMPP1/FadL/TodX) BBP2 PF07642.11 CAV17864.1 - 6.9e-06 25.4 11.6 0.00032 20.0 4.3 2.3 1 1 0 2 2 2 2 Putative beta-barrel porin-2, OmpL-like. bbp2 DUF2490 PF10677.9 CAV17864.1 - 4.4e-05 23.5 0.3 0.53 10.2 0.0 3.7 3 1 1 4 4 4 2 Protein of unknown function (DUF2490) OmpA_membrane PF01389.17 CAV17864.1 - 0.0077 16.0 6.6 0.13 11.9 0.0 3.7 1 1 1 3 3 3 2 OmpA-like transmembrane domain OMP_b-brl_2 PF13568.6 CAV17864.1 - 0.0085 16.1 5.6 0.15 12.1 0.2 3.7 2 2 1 3 3 3 1 Outer membrane protein beta-barrel domain CBM_21 PF03370.13 CAV17864.1 - 0.098 12.8 0.1 0.21 11.8 0.1 1.5 1 0 0 1 1 1 0 Carbohydrate/starch-binding module (family 21) Toluene_X PF03349.16 CAV17865.1 - 6.5e-123 410.5 16.9 1.6e-121 405.9 16.9 2.0 1 1 0 1 1 1 1 Outer membrane protein transport protein (OMPP1/FadL/TodX) DUF2490 PF10677.9 CAV17865.1 - 1.9e-05 24.7 4.9 0.62 10.0 0.6 4.1 2 1 2 4 4 4 2 Protein of unknown function (DUF2490) OMP_b-brl PF13505.6 CAV17865.1 - 0.002 18.3 27.9 0.23 11.6 6.6 3.3 2 2 0 2 2 2 2 Outer membrane protein beta-barrel domain OMP_b-brl_2 PF13568.6 CAV17865.1 - 0.0021 18.1 4.7 1.3 9.0 0.2 3.4 2 1 1 3 3 3 2 Outer membrane protein beta-barrel domain OmpA_membrane PF01389.17 CAV17865.1 - 0.053 13.3 2.6 0.25 11.0 0.1 3.0 3 1 0 3 3 3 0 OmpA-like transmembrane domain Autotransporter PF03797.19 CAV17865.1 - 5.3 6.6 21.1 3.8 7.1 5.2 3.4 2 2 1 3 3 3 0 Autotransporter beta-domain DUF3379 PF11859.8 CAV17866.1 - 1.2e-84 283.3 0.3 1.3e-84 283.1 0.3 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3379) RRM_5 PF13893.6 CAV17866.1 - 0.011 15.3 0.2 0.027 14.1 0.1 1.6 1 1 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) HgmA PF04209.13 CAV17866.1 - 0.044 12.5 0.1 0.057 12.1 0.1 1.1 1 0 0 1 1 1 0 homogentisate 1,2-dioxygenase Sigma70_r2 PF04542.14 CAV17867.1 - 1.3e-17 63.3 2.5 2.6e-17 62.4 2.5 1.5 1 0 0 1 1 1 1 Sigma-70 region 2 Sigma70_r4_2 PF08281.12 CAV17867.1 - 1.9e-11 43.4 0.0 3.3e-11 42.7 0.0 1.4 1 0 0 1 1 1 1 Sigma-70, region 4 Sigma70_ECF PF07638.11 CAV17867.1 - 0.00099 19.0 0.5 0.0019 18.1 0.5 1.6 1 1 0 1 1 1 1 ECF sigma factor Sigma70_r4 PF04545.16 CAV17867.1 - 0.0093 15.5 0.0 0.021 14.3 0.0 1.6 1 0 0 1 1 1 1 Sigma-70, region 4 GerE PF00196.19 CAV17867.1 - 0.045 13.3 0.0 0.091 12.3 0.0 1.5 1 0 0 1 1 1 0 Bacterial regulatory proteins, luxR family Thiolase_N PF00108.23 CAV17868.1 - 1.1e-62 211.7 2.6 1.7e-62 211.2 2.6 1.3 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 CAV17868.1 - 1.9e-35 121.2 1.8 2.4e-35 120.8 0.5 1.9 2 0 0 2 2 2 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.26 CAV17868.1 - 0.00012 21.8 5.7 0.00076 19.1 2.5 3.1 3 1 0 3 3 3 1 Beta-ketoacyl synthase, N-terminal domain 3HCDH_N PF02737.18 CAV17869.1 - 3.1e-53 180.3 1.1 5.2e-53 179.6 0.4 1.8 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain ECH_1 PF00378.20 CAV17869.1 - 8.2e-38 130.1 0.0 2.2e-37 128.7 0.0 1.7 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase 3HCDH PF00725.22 CAV17869.1 - 3.2e-33 114.2 0.0 1.9e-23 82.9 0.0 3.0 3 0 0 3 3 3 2 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain ECH_2 PF16113.5 CAV17869.1 - 4.6e-27 95.4 0.0 8e-27 94.6 0.0 1.3 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase YcaO PF02624.16 CAV17869.1 - 0.15 11.3 0.0 0.34 10.1 0.0 1.6 2 0 0 2 2 2 0 YcaO cyclodehydratase, ATP-ad Mg2+-binding Peptidase_M16_M PF16187.5 CAV17871.1 - 1.2e-82 277.3 0.4 2.9e-82 276.1 0.1 1.8 2 0 0 2 2 2 1 Middle or third domain of peptidase_M16 Peptidase_M16 PF00675.20 CAV17871.1 - 7.7e-41 139.5 1.0 3.2e-38 131.0 0.4 2.6 2 0 0 2 2 2 2 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.21 CAV17871.1 - 4.4e-34 118.1 0.1 2.8e-21 76.4 0.0 2.9 3 0 0 3 3 3 2 Peptidase M16 inactive domain His_Phos_1 PF00300.22 CAV17873.1 - 2.7e-08 33.7 0.0 3.1e-07 30.3 0.0 1.9 1 1 1 2 2 2 2 Histidine phosphatase superfamily (branch 1) Smr PF01713.21 CAV17874.1 - 7.4e-19 67.9 0.2 1.3e-18 67.1 0.2 1.4 1 0 0 1 1 1 1 Smr domain Phage_GPO PF05929.11 CAV17874.1 - 0.086 12.5 0.1 0.11 12.1 0.1 1.1 1 0 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase MTS PF05175.14 CAV17875.1 - 3.2e-19 69.1 0.0 2e-17 63.3 0.0 2.2 1 1 1 2 2 2 1 Methyltransferase small domain Methyltransf_31 PF13847.6 CAV17875.1 - 1.2e-13 51.1 0.0 1.6e-13 50.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CAV17875.1 - 3.4e-09 37.3 0.0 6.4e-09 36.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 CAV17875.1 - 5.9e-08 32.5 0.0 8.4e-08 31.9 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_15 PF09445.10 CAV17875.1 - 4e-06 26.5 0.0 6e-06 25.9 0.0 1.2 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase Methyltransf_18 PF12847.7 CAV17875.1 - 4.2e-06 26.8 0.0 1.1e-05 25.4 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain Cons_hypoth95 PF03602.15 CAV17875.1 - 4.5e-05 23.2 0.0 7.6e-05 22.4 0.0 1.3 1 0 0 1 1 1 1 Conserved hypothetical protein 95 Met_10 PF02475.16 CAV17875.1 - 6.9e-05 22.7 0.0 0.0002 21.1 0.0 1.7 2 0 0 2 2 2 1 Met-10+ like-protein UPF0020 PF01170.18 CAV17875.1 - 7.3e-05 22.5 1.1 0.00023 20.9 1.1 1.7 1 1 0 1 1 1 1 Putative RNA methylase family UPF0020 Ubie_methyltran PF01209.18 CAV17875.1 - 0.00017 21.0 0.0 0.00026 20.4 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_12 PF08242.12 CAV17875.1 - 0.0004 21.1 0.0 0.0023 18.7 0.0 2.1 3 0 0 3 3 2 1 Methyltransferase domain Methyltransf_2 PF00891.18 CAV17875.1 - 0.00064 19.1 0.0 0.0011 18.4 0.0 1.3 1 0 0 1 1 1 1 O-methyltransferase domain CMAS PF02353.20 CAV17875.1 - 0.0054 16.1 0.0 0.0069 15.7 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase N6_Mtase PF02384.16 CAV17875.1 - 0.0059 15.9 0.0 0.009 15.3 0.0 1.2 1 0 0 1 1 1 1 N-6 DNA Methylase Methyltransf_4 PF02390.17 CAV17875.1 - 0.018 14.5 0.0 0.059 12.8 0.0 1.9 2 0 0 2 2 2 0 Putative methyltransferase Methyltransf_11 PF08241.12 CAV17875.1 - 0.018 15.7 0.0 0.045 14.4 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_10 PF05971.12 CAV17875.1 - 0.053 12.8 0.0 0.079 12.3 0.0 1.2 1 0 0 1 1 1 0 RNA methyltransferase AviRa PF11599.8 CAV17875.1 - 0.13 11.7 0.0 0.2 11.1 0.0 1.3 1 0 0 1 1 1 0 RRNA methyltransferase AviRa DUF938 PF06080.12 CAV17875.1 - 0.17 11.6 0.0 0.28 10.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF938) LysE PF01810.18 CAV17876.1 - 2e-35 122.0 10.5 2.4e-35 121.8 10.5 1.0 1 0 0 1 1 1 1 LysE type translocator TerC PF03741.16 CAV17876.1 - 0.0019 17.9 2.1 0.0041 16.8 1.2 1.9 1 1 1 2 2 2 1 Integral membrane protein TerC family Phage_holin_3_6 PF07332.11 CAV17876.1 - 0.15 12.1 0.2 0.15 12.1 0.2 2.5 2 0 0 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III CrgA PF06781.12 CAV17876.1 - 0.19 11.8 1.1 0.49 10.5 1.1 1.7 1 0 0 1 1 1 0 Cell division protein CrgA Oxidored_q4 PF00507.19 CAV17876.1 - 6.9 6.9 8.5 1.9 8.7 2.4 2.6 2 1 2 4 4 4 0 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3 UPF0061 PF02696.14 CAV17878.1 - 4.2e-152 507.2 0.0 5.1e-152 506.9 0.0 1.0 1 0 0 1 1 1 1 Uncharacterized ACR, YdiU/UPF0061 family Response_reg PF00072.24 CAV17879.1 - 7e-30 103.5 0.1 1.1e-29 102.8 0.1 1.3 1 0 0 1 1 1 1 Response regulator receiver domain Trans_reg_C PF00486.28 CAV17879.1 - 4.7e-15 55.4 0.0 9.1e-15 54.5 0.0 1.5 1 0 0 1 1 1 1 Transcriptional regulatory protein, C terminal HATPase_c PF02518.26 CAV17881.1 - 2e-18 66.9 0.0 3.7e-18 66.1 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HAMP PF00672.25 CAV17881.1 - 7e-09 35.9 4.2 8.1e-09 35.7 2.6 2.0 2 0 0 2 2 2 1 HAMP domain HisKA PF00512.25 CAV17881.1 - 4.7e-06 26.5 1.2 1.8e-05 24.7 0.1 2.4 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain HATPase_c_5 PF14501.6 CAV17881.1 - 0.011 15.7 0.0 0.041 13.8 0.0 2.0 1 1 0 1 1 1 0 GHKL domain HATPase_c_3 PF13589.6 CAV17881.1 - 0.025 14.4 0.0 0.052 13.4 0.0 1.5 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Pullulanase_Ins PF18494.1 CAV17881.1 - 0.027 14.9 0.0 0.069 13.6 0.0 1.7 1 0 0 1 1 1 0 Pullulanase Ins domain HATPase_c_2 PF13581.6 CAV17881.1 - 0.055 13.4 0.0 0.11 12.5 0.0 1.5 1 0 0 1 1 1 0 Histidine kinase-like ATPase domain DUF3176 PF11374.8 CAV17881.1 - 0.083 13.1 0.4 0.19 12.0 0.4 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3176) HisKA_3 PF07730.13 CAV17881.1 - 0.12 12.9 2.9 0.55 10.8 0.1 2.6 2 0 0 2 2 2 0 Histidine kinase SBP_bac_1 PF01547.25 CAV17882.1 - 9.4e-19 68.5 10.4 9.4e-19 68.5 10.4 1.7 2 0 0 2 2 2 1 Bacterial extracellular solute-binding protein BPD_transp_1 PF00528.22 CAV17883.1 - 1.8e-12 47.4 14.8 1.8e-12 47.4 14.8 2.0 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component DUF3433 PF11915.8 CAV17883.1 - 1.7 9.1 9.2 0.38 11.2 1.6 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF3433) BPD_transp_1 PF00528.22 CAV17884.1 - 1.8e-17 63.7 18.0 1.8e-17 63.7 18.0 2.1 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component ABC_tran PF00005.27 CAV17885.1 - 1.4e-32 113.1 0.0 2.9e-32 112.1 0.0 1.5 1 0 0 1 1 1 1 ABC transporter OB_MalK PF17912.1 CAV17885.1 - 3.3e-11 43.8 0.1 1.3e-10 42.0 0.1 2.1 1 0 0 1 1 1 1 MalK OB fold domain AAA_21 PF13304.6 CAV17885.1 - 5e-09 36.4 0.0 0.0024 17.7 0.0 2.2 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 CAV17885.1 - 1.5e-07 31.1 0.6 9.5e-07 28.5 0.6 2.0 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain RsgA_GTPase PF03193.16 CAV17885.1 - 4.3e-06 26.7 0.4 2.9e-05 24.0 0.1 2.1 2 0 0 2 2 2 1 RsgA GTPase TOBE_2 PF08402.10 CAV17885.1 - 0.0001 22.4 0.0 0.00043 20.4 0.0 2.1 2 0 0 2 2 2 1 TOBE domain AAA_15 PF13175.6 CAV17885.1 - 0.00025 20.9 0.1 0.0088 15.8 0.0 2.1 1 1 1 2 2 2 1 AAA ATPase domain AAA_29 PF13555.6 CAV17885.1 - 0.00036 20.2 0.1 0.0009 18.9 0.1 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_22 PF13401.6 CAV17885.1 - 0.00054 20.2 0.2 0.0027 18.0 0.2 2.2 2 1 0 2 2 2 1 AAA domain AAA_16 PF13191.6 CAV17885.1 - 0.00063 20.2 0.3 0.0026 18.2 0.3 2.0 1 1 0 1 1 1 1 AAA ATPase domain AAA PF00004.29 CAV17885.1 - 0.0037 17.7 0.0 0.016 15.6 0.0 2.0 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Rad17 PF03215.15 CAV17885.1 - 0.0042 17.0 0.0 0.0071 16.3 0.0 1.3 1 0 0 1 1 1 1 Rad17 P-loop domain AAA_5 PF07728.14 CAV17885.1 - 0.0062 16.5 0.1 0.042 13.8 0.0 2.3 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) RNA_helicase PF00910.22 CAV17885.1 - 0.0088 16.4 0.0 0.031 14.7 0.0 1.9 2 0 0 2 2 1 1 RNA helicase NTPase_1 PF03266.15 CAV17885.1 - 0.011 15.6 0.1 0.16 11.9 0.0 2.6 3 0 0 3 3 3 0 NTPase MMR_HSR1 PF01926.23 CAV17885.1 - 0.012 15.7 0.0 0.034 14.2 0.0 1.9 2 0 0 2 2 1 0 50S ribosome-binding GTPase CysA_C_terminal PF17850.1 CAV17885.1 - 0.013 16.1 0.1 0.07 13.7 0.0 2.2 2 0 0 2 2 2 0 CysA C-terminal regulatory domain Septin PF00735.18 CAV17885.1 - 0.014 14.7 0.0 0.064 12.5 0.0 1.9 2 0 0 2 2 2 0 Septin AAA_23 PF13476.6 CAV17885.1 - 0.023 15.2 0.7 0.041 14.4 0.1 1.7 2 0 0 2 2 1 0 AAA domain FeoB_N PF02421.18 CAV17885.1 - 0.024 14.2 0.7 0.41 10.2 0.0 2.8 3 0 0 3 3 3 0 Ferrous iron transport protein B AAA_33 PF13671.6 CAV17885.1 - 0.025 14.8 0.3 0.11 12.7 0.3 2.1 1 1 0 1 1 1 0 AAA domain AAA_14 PF13173.6 CAV17885.1 - 0.028 14.5 0.0 0.12 12.4 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_30 PF13604.6 CAV17885.1 - 0.029 14.1 0.1 0.076 12.7 0.0 1.8 1 1 0 1 1 1 0 AAA domain ATPase_2 PF01637.18 CAV17885.1 - 0.03 14.3 0.1 0.18 11.7 0.0 2.1 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea NACHT PF05729.12 CAV17885.1 - 0.04 13.8 0.0 0.1 12.5 0.0 1.7 1 0 0 1 1 1 0 NACHT domain T2SSE PF00437.20 CAV17885.1 - 0.041 13.0 0.2 0.083 11.9 0.0 1.7 2 0 0 2 2 2 0 Type II/IV secretion system protein Mg_chelatase PF01078.21 CAV17885.1 - 0.046 13.1 0.0 0.079 12.3 0.0 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_18 PF13238.6 CAV17885.1 - 0.046 14.3 0.2 0.2 12.2 0.2 2.1 1 1 0 1 1 1 0 AAA domain AAA_25 PF13481.6 CAV17885.1 - 0.046 13.3 0.5 0.087 12.4 0.0 1.7 2 0 0 2 2 1 0 AAA domain IstB_IS21 PF01695.17 CAV17885.1 - 0.066 13.0 0.0 0.12 12.1 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein AIG1 PF04548.16 CAV17885.1 - 0.068 12.5 0.0 0.12 11.6 0.0 1.4 1 0 0 1 1 1 0 AIG1 family NB-ARC PF00931.22 CAV17885.1 - 0.076 12.2 0.1 0.16 11.1 0.1 1.5 1 0 0 1 1 1 0 NB-ARC domain AAA_24 PF13479.6 CAV17885.1 - 0.094 12.4 0.2 1.6 8.4 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_28 PF13521.6 CAV17885.1 - 0.12 12.7 0.2 0.6 10.3 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_17 PF13207.6 CAV17885.1 - 0.12 12.8 0.1 1.8 9.0 0.0 2.7 2 0 0 2 2 2 0 AAA domain Peptidase_S8 PF00082.22 CAV17886.1 - 3.4e-32 111.9 15.6 5.1e-32 111.3 15.6 1.2 1 0 0 1 1 1 1 Subtilase family Inhibitor_I9 PF05922.16 CAV17886.1 - 2e-05 25.1 0.0 3.7e-05 24.3 0.0 1.5 1 0 0 1 1 1 1 Peptidase inhibitor I9 GTP-bdg_N PF13167.6 CAV17887.1 - 9.2e-21 74.3 0.5 2.3e-19 69.9 0.1 2.9 2 1 0 2 2 1 1 GTP-binding GTPase N-terminal GTP-bdg_M PF16360.5 CAV17887.1 - 2.8e-20 72.7 7.1 8.5e-20 71.2 7.1 1.9 1 0 0 1 1 1 1 GTP-binding GTPase Middle Region MMR_HSR1 PF01926.23 CAV17887.1 - 1.6e-15 57.2 0.1 4.8e-15 55.6 0.1 1.8 2 0 0 2 2 2 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 CAV17887.1 - 0.0013 18.6 0.3 1.2 9.1 0.1 3.0 3 1 1 4 4 4 2 RsgA GTPase cobW PF02492.19 CAV17887.1 - 0.0018 17.9 0.5 0.014 15.0 0.1 2.2 1 1 1 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain Gtr1_RagA PF04670.12 CAV17887.1 - 0.0044 16.4 0.0 0.0084 15.5 0.0 1.5 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1_Xtn PF16897.5 CAV17887.1 - 0.0071 16.3 0.0 0.018 15.0 0.0 1.6 1 0 0 1 1 1 1 C-terminal region of MMR_HSR1 domain FeoB_N PF02421.18 CAV17887.1 - 0.018 14.6 0.5 0.16 11.5 0.3 2.6 2 1 0 2 2 2 0 Ferrous iron transport protein B GTP_EFTU PF00009.27 CAV17887.1 - 0.023 14.2 0.1 0.28 10.7 0.0 2.3 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain Dynamin_N PF00350.23 CAV17887.1 - 0.047 13.7 0.1 1.1 9.3 0.0 2.4 1 1 1 2 2 2 0 Dynamin family ABC_tran PF00005.27 CAV17887.1 - 0.13 12.8 0.0 0.34 11.4 0.0 1.7 1 0 0 1 1 1 0 ABC transporter MinE PF03776.14 CAV17888.1 - 1.8e-21 75.9 0.1 2.1e-21 75.7 0.1 1.0 1 0 0 1 1 1 1 Septum formation topological specificity factor MinE AAA_31 PF13614.6 CAV17889.1 - 8.4e-20 71.4 0.1 1.8e-19 70.3 0.1 1.5 1 1 0 1 1 1 1 AAA domain CbiA PF01656.23 CAV17889.1 - 1.5e-18 67.1 0.1 2e-18 66.6 0.1 1.2 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain ParA PF10609.9 CAV17889.1 - 8e-16 58.2 0.7 3.4e-15 56.2 0.7 2.0 1 1 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase MipZ PF09140.11 CAV17889.1 - 3.3e-09 36.4 0.9 7.3e-09 35.3 0.9 1.6 1 1 0 1 1 1 1 ATPase MipZ ArsA_ATPase PF02374.15 CAV17889.1 - 1.1e-07 31.3 3.4 2.5e-07 30.2 2.5 1.9 2 0 0 2 2 2 1 Anion-transporting ATPase CBP_BcsQ PF06564.12 CAV17889.1 - 1.3e-05 24.8 0.0 2.3e-05 24.0 0.0 1.4 1 0 0 1 1 1 1 Cellulose biosynthesis protein BcsQ Fer4_NifH PF00142.18 CAV17889.1 - 0.00058 19.4 0.4 0.0072 15.8 0.2 2.2 2 1 0 2 2 2 1 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family AAA_24 PF13479.6 CAV17889.1 - 0.00086 19.1 0.0 0.0013 18.5 0.0 1.3 1 0 0 1 1 1 1 AAA domain MeaB PF03308.16 CAV17889.1 - 0.0013 17.8 1.0 0.0071 15.4 1.0 1.9 1 1 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB VirC1 PF07015.11 CAV17889.1 - 0.0018 17.6 0.5 0.0055 16.0 0.3 1.8 2 1 1 3 3 3 1 VirC1 protein CLP1_P PF16575.5 CAV17889.1 - 0.006 16.4 0.1 0.02 14.7 0.1 1.7 2 0 0 2 2 2 1 mRNA cleavage and polyadenylation factor CLP1 P-loop SRP54 PF00448.22 CAV17889.1 - 0.025 14.2 2.1 0.084 12.5 0.9 2.1 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain AAA_26 PF13500.6 CAV17889.1 - 0.057 13.2 2.4 4.7 7.0 1.7 2.3 2 0 0 2 2 2 0 AAA domain MinC_C PF03775.16 CAV17890.1 - 1.2e-31 108.7 0.2 2.1e-31 107.9 0.2 1.4 1 0 0 1 1 1 1 Septum formation inhibitor MinC, C-terminal domain MinC_N PF05209.13 CAV17890.1 - 3.2e-30 104.1 0.0 4.9e-30 103.6 0.0 1.3 1 0 0 1 1 1 1 Septum formation inhibitor MinC, N-terminal domain FapA PF03961.13 CAV17890.1 - 0.013 14.2 0.2 0.017 13.8 0.2 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A YcgL PF05166.13 CAV17892.1 - 6.4e-32 109.7 0.3 1.1e-31 108.9 0.1 1.5 2 0 0 2 2 2 1 YcgL domain SLT_2 PF13406.6 CAV17894.1 - 5.8e-109 363.8 0.6 6.5e-109 363.7 0.6 1.0 1 0 0 1 1 1 1 Transglycosylase SLT domain Glucosaminidase PF01832.20 CAV17894.1 - 0.03 14.8 0.0 0.063 13.8 0.0 1.8 1 1 0 1 1 1 0 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase LysR_substrate PF03466.20 CAV17895.1 - 1.8e-42 145.1 0.0 2.5e-42 144.6 0.0 1.2 1 0 0 1 1 1 1 LysR substrate binding domain HTH_1 PF00126.27 CAV17895.1 - 4.3e-17 61.8 0.3 7.8e-17 61.0 0.3 1.5 1 0 0 1 1 1 1 Bacterial regulatory helix-turn-helix protein, lysR family MARCKS PF02063.17 CAV17895.1 - 0.18 11.8 0.0 0.25 11.3 0.0 1.1 1 0 0 1 1 1 0 MARCKS family Nucleos_tra2_C PF07662.13 CAV17896.1 - 2.6e-74 249.5 12.0 2.6e-74 249.5 12.0 2.4 2 1 0 2 2 2 1 Na+ dependent nucleoside transporter C-terminus Nucleos_tra2_N PF01773.20 CAV17896.1 - 1.9e-23 82.9 1.9 1.9e-23 82.9 1.9 3.2 2 0 0 2 2 2 1 Na+ dependent nucleoside transporter N-terminus Gate PF07670.14 CAV17896.1 - 4.9e-07 30.0 5.2 4.9e-07 30.0 5.2 3.4 3 0 0 3 3 3 1 Nucleoside recognition Na_H_Exchanger PF00999.21 CAV17897.1 - 2.5e-33 115.4 41.7 3.2e-33 115.1 41.7 1.1 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family TrkA_N PF02254.18 CAV17897.1 - 0.0014 18.9 0.0 0.0064 16.7 0.0 2.0 2 0 0 2 2 2 1 TrkA-N domain THF_DHG_CYH_C PF02882.19 CAV17898.1 - 5.4e-69 230.6 0.3 7.8e-69 230.1 0.3 1.2 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain THF_DHG_CYH PF00763.23 CAV17898.1 - 1.8e-39 134.6 0.0 2.6e-39 134.1 0.0 1.2 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain UDPG_MGDP_dh_N PF03721.14 CAV17898.1 - 0.064 12.8 0.0 0.11 12.0 0.0 1.4 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Acetyltransf_10 PF13673.7 CAV17899.1 - 7.4e-11 42.1 0.0 1.4e-10 41.2 0.0 1.6 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 CAV17899.1 - 4.1e-08 33.5 0.0 5.9e-08 33.0 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 CAV17899.1 - 2.1e-06 28.0 0.0 2.6e-06 27.7 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_9 PF13527.7 CAV17899.1 - 0.0002 21.4 0.0 0.00067 19.7 0.0 1.9 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 CAV17899.1 - 0.014 15.5 0.0 0.022 14.9 0.0 1.4 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase Acetyltransf_15 PF17013.5 CAV17899.1 - 0.074 12.5 0.0 0.089 12.2 0.0 1.2 1 0 0 1 1 1 0 Putative acetyl-transferase Acetyltransf_5 PF13444.6 CAV17899.1 - 0.14 12.8 0.0 1.6 9.5 0.0 2.1 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain Chorismate_synt PF01264.21 CAV17900.1 - 6.7e-143 475.3 0.0 7.6e-143 475.1 0.0 1.0 1 0 0 1 1 1 1 Chorismate synthase ChaB PF06150.12 CAV17900.1 - 0.084 13.5 0.1 0.15 12.6 0.1 1.4 1 0 0 1 1 1 0 ChaB UPF0126 PF03458.13 CAV17902.1 - 9.5e-41 137.6 19.1 5.4e-21 74.3 3.2 2.5 3 0 0 3 3 3 2 UPF0126 domain CSG2 PF16965.5 CAV17902.1 - 0.48 9.3 7.0 0.046 12.7 2.2 1.8 2 1 0 2 2 2 0 Ceramide synthase regulator SLATT_fungal PF18142.1 CAV17902.1 - 1.2 9.1 6.3 0.14 12.2 1.5 1.9 2 0 0 2 2 2 0 SMODS and SLOG-associating 2TM effector domain EpmC PF04315.12 CAV17904.1 - 5.8e-72 240.7 0.0 6.6e-72 240.5 0.0 1.0 1 0 0 1 1 1 1 Elongation factor P hydroxylase MPTase-PolyVal PF18818.1 CAV17904.1 - 0.0035 17.4 0.0 0.0052 16.8 0.0 1.2 1 0 0 1 1 1 1 Metallopeptidase superfamily domain YfcL PF08891.11 CAV17905.1 - 3.3e-31 107.5 0.1 3.7e-31 107.3 0.1 1.0 1 0 0 1 1 1 1 YfcL protein FMN_red PF03358.15 CAV17906.1 - 1.4e-24 86.6 0.0 1.8e-24 86.3 0.0 1.1 1 0 0 1 1 1 1 NADPH-dependent FMN reductase Flavodoxin_2 PF02525.17 CAV17906.1 - 2.2e-07 30.8 0.0 2.6e-07 30.5 0.0 1.2 1 0 0 1 1 1 1 Flavodoxin-like fold Methyltransf_30 PF05430.11 CAV17907.1 - 1.4e-45 154.2 0.0 2.5e-45 153.4 0.0 1.4 1 0 0 1 1 1 1 S-adenosyl-L-methionine-dependent methyltransferase DAO PF01266.24 CAV17907.1 - 7.5e-43 147.4 0.0 1.1e-42 147.0 0.0 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 CAV17907.1 - 0.00011 22.4 0.1 0.00028 21.1 0.1 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 CAV17907.1 - 0.00014 21.2 0.1 0.00038 19.8 0.1 1.7 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 CAV17907.1 - 0.00029 20.2 0.1 0.6 9.3 0.0 3.2 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase Mqo PF06039.15 CAV17907.1 - 0.00043 19.0 1.1 0.28 9.7 0.3 2.3 2 0 0 2 2 2 2 Malate:quinone oxidoreductase (Mqo) K_oxygenase PF13434.6 CAV17907.1 - 0.044 12.9 0.6 3.4 6.7 0.0 2.2 2 0 0 2 2 2 0 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_9 PF13454.6 CAV17907.1 - 0.064 13.2 2.1 3.3 7.7 0.2 3.1 3 0 0 3 3 3 0 FAD-NAD(P)-binding FAD_binding_2 PF00890.24 CAV17907.1 - 0.089 11.9 0.3 0.18 10.8 0.3 1.5 1 0 0 1 1 1 0 FAD binding domain Pyr_redox PF00070.27 CAV17907.1 - 0.12 13.0 0.0 0.36 11.4 0.0 1.8 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase ketoacyl-synt PF00109.26 CAV17908.1 - 3.1e-44 151.5 2.9 4.4e-44 151.0 2.9 1.2 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.22 CAV17908.1 - 2.8e-27 95.1 3.4 3.6e-27 94.7 0.9 2.3 3 0 0 3 3 3 1 Beta-ketoacyl synthase, C-terminal domain KAsynt_C_assoc PF16197.5 CAV17908.1 - 0.0025 18.3 0.0 0.0044 17.5 0.0 1.5 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension Thiolase_N PF00108.23 CAV17908.1 - 0.0083 15.5 0.1 0.0083 15.5 0.1 1.8 3 0 0 3 3 3 1 Thiolase, N-terminal domain CaMKII_AD PF08332.10 CAV17908.1 - 0.15 12.2 0.0 0.25 11.5 0.0 1.3 1 0 0 1 1 1 0 Calcium/calmodulin dependent protein kinase II association domain 2-Hacid_dh_C PF02826.19 CAV17911.1 - 1.9e-35 121.8 0.0 3.9e-35 120.8 0.0 1.5 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain DUF3410 PF11890.8 CAV17911.1 - 1.3e-29 101.8 0.0 5.7e-29 99.7 0.0 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF3410) 2-Hacid_dh PF00389.30 CAV17911.1 - 4.1e-24 84.8 0.0 5.4e-24 84.4 0.0 1.1 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain IlvN PF07991.12 CAV17911.1 - 0.0027 17.3 0.1 0.0084 15.7 0.0 1.9 2 0 0 2 2 2 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain XdhC_C PF13478.6 CAV17911.1 - 0.034 14.6 0.0 0.074 13.6 0.0 1.6 1 0 0 1 1 1 0 XdhC Rossmann domain AdoHcyase_NAD PF00670.21 CAV17911.1 - 0.059 13.4 0.0 0.15 12.1 0.0 1.7 1 0 0 1 1 1 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain Shikimate_DH PF01488.20 CAV17911.1 - 0.065 13.3 0.2 0.74 9.9 0.2 2.4 1 1 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase NAD_binding_2 PF03446.15 CAV17911.1 - 0.079 13.1 0.0 0.22 11.7 0.0 1.8 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase 3HCDH_N PF02737.18 CAV17911.1 - 0.082 12.8 0.0 0.15 12.0 0.0 1.5 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain ThiF PF00899.21 CAV17911.1 - 0.087 12.2 0.2 0.17 11.2 0.2 1.4 1 0 0 1 1 1 0 ThiF family Rossmann-like PF10727.9 CAV17911.1 - 0.094 12.6 0.0 0.24 11.2 0.0 1.6 1 0 0 1 1 1 0 Rossmann-like domain TrkA_N PF02254.18 CAV17911.1 - 0.17 12.1 0.4 4.4 7.6 0.1 2.5 2 0 0 2 2 2 0 TrkA-N domain UDPG_MGDP_dh_N PF03721.14 CAV17911.1 - 0.75 9.3 2.3 4.8 6.7 2.3 2.2 1 1 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Semialdhyde_dhC PF02774.18 CAV17912.1 - 5.9e-60 202.5 0.0 1e-59 201.7 0.0 1.4 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, dimerisation domain Semialdhyde_dh PF01118.24 CAV17912.1 - 3.8e-32 111.3 0.0 1.1e-31 109.7 0.0 1.8 2 0 0 2 2 2 1 Semialdehyde dehydrogenase, NAD binding domain DXP_reductoisom PF02670.16 CAV17912.1 - 0.013 16.2 0.0 0.032 14.9 0.0 1.7 1 0 0 1 1 1 0 1-deoxy-D-xylulose 5-phosphate reductoisomerase Gp_dh_C PF02800.20 CAV17912.1 - 0.038 13.6 0.0 0.16 11.5 0.0 1.9 2 0 0 2 2 2 0 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain DapB_N PF01113.20 CAV17912.1 - 0.038 14.1 0.5 0.66 10.1 0.1 2.5 2 1 0 2 2 2 0 Dihydrodipicolinate reductase, N-terminus Ldh_1_N PF00056.23 CAV17912.1 - 0.094 12.8 0.0 0.21 11.6 0.0 1.6 1 0 0 1 1 1 0 lactate/malate dehydrogenase, NAD binding domain Trypan_PARP PF05887.11 CAV17913.1 - 0.0019 18.2 39.5 0.0019 18.2 39.5 7.7 3 1 5 8 8 8 1 Procyclic acidic repetitive protein (PARP) DUF469 PF04320.14 CAV17913.1 - 0.39 11.6 5.1 9 7.2 0.0 4.2 4 0 0 4 4 4 0 Protein with unknown function (DUF469) PseudoU_synth_1 PF01416.20 CAV17914.1 - 1.2e-42 144.7 0.2 2.7e-29 101.8 0.0 2.1 2 0 0 2 2 2 2 tRNA pseudouridine synthase Carboxyl_trans PF01039.22 CAV17915.1 - 1.8e-13 49.9 0.0 2.3e-13 49.6 0.0 1.2 1 0 0 1 1 1 1 Carboxyl transferase domain zf-ACC PF17848.1 CAV17915.1 - 5.8e-13 48.7 5.1 9.9e-13 47.9 5.1 1.4 1 0 0 1 1 1 1 Acetyl-coA carboxylase zinc finger domain Tmemb_55A PF09788.9 CAV17915.1 - 0.037 13.1 0.4 0.066 12.3 0.4 1.3 1 0 0 1 1 1 0 Transmembrane protein 55A Mur_ligase_M PF08245.12 CAV17916.1 - 1.5e-08 34.9 0.0 2.2e-07 31.1 0.0 2.3 2 1 0 2 2 2 1 Mur ligase middle domain Mur_ligase_C PF02875.21 CAV17916.1 - 4.7e-07 30.0 0.0 2.9e-06 27.4 0.0 2.2 2 0 0 2 2 2 1 Mur ligase family, glutamate ligase domain SPOR PF05036.13 CAV17917.1 - 1e-12 48.3 0.3 2.3e-12 47.1 0.1 1.7 2 0 0 2 2 2 1 Sporulation related domain Colicin_V PF02674.16 CAV17918.1 - 4.7e-38 130.4 12.7 5.8e-38 130.1 12.7 1.1 1 0 0 1 1 1 1 Colicin V production protein DUF2208 PF09973.9 CAV17918.1 - 0.054 13.1 1.0 0.087 12.4 1.0 1.3 1 0 0 1 1 1 0 Predicted membrane protein (DUF2208) Rick_17kDa_Anti PF05433.15 CAV17918.1 - 2 8.4 6.2 0.65 9.9 3.5 1.7 2 0 0 2 2 2 0 Glycine zipper 2TM domain Lig_chan PF00060.26 CAV17918.1 - 7.5 6.4 7.1 7.2 6.4 2.0 2.4 1 1 1 3 3 3 0 Ligand-gated ion channel GATase_6 PF13522.6 CAV17920.1 - 1.8e-17 63.8 0.0 3.6e-17 62.8 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_7 PF13537.6 CAV17920.1 - 2.3e-15 56.6 0.0 4.2e-15 55.7 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_4 PF13230.6 CAV17920.1 - 1.8e-06 27.1 0.0 3.9e-06 26.0 0.0 1.6 2 0 0 2 2 2 1 Glutamine amidotransferases class-II Pribosyltran PF00156.27 CAV17920.1 - 2.3e-05 24.0 0.0 4.3e-05 23.1 0.0 1.3 1 0 0 1 1 1 1 Phosphoribosyl transferase domain LysR_substrate PF03466.20 CAV17921.1 - 8.4e-41 139.6 0.0 1.2e-40 139.2 0.0 1.2 1 0 0 1 1 1 1 LysR substrate binding domain HTH_1 PF00126.27 CAV17921.1 - 1.3e-13 50.7 0.2 2.5e-13 49.8 0.2 1.5 1 0 0 1 1 1 1 Bacterial regulatory helix-turn-helix protein, lysR family HTH_30 PF13556.6 CAV17921.1 - 0.013 15.3 0.5 0.034 13.9 0.5 1.7 1 0 0 1 1 1 0 PucR C-terminal helix-turn-helix domain Taeniidae_ag PF05596.11 CAV17921.1 - 0.074 13.0 0.0 0.33 11.0 0.0 2.0 1 1 1 2 2 2 0 Taeniidae antigen Response_reg PF00072.24 CAV17922.1 - 4.7e-27 94.4 0.1 8.4e-27 93.6 0.1 1.4 1 0 0 1 1 1 1 Response regulator receiver domain DUF2713 PF10897.8 CAV17922.1 - 0.089 12.4 0.0 0.2 11.3 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2713) DUF454 PF04304.13 CAV17925.1 - 3.5e-18 65.7 1.9 3.9e-18 65.5 1.9 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF454) Pribosyltran PF00156.27 CAV17926.1 - 6e-14 51.9 0.0 7.2e-14 51.6 0.0 1.1 1 0 0 1 1 1 1 Phosphoribosyl transferase domain UPRTase PF14681.6 CAV17926.1 - 0.0084 15.6 0.0 0.011 15.2 0.0 1.1 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase DNA_pol3_tau_5 PF12170.8 CAV17928.1 - 2.1e-48 164.0 3.1 2.1e-48 164.0 3.1 2.0 2 0 0 2 2 2 1 DNA polymerase III tau subunit V interacting with alpha DNA_pol3_delta2 PF13177.6 CAV17928.1 - 4.1e-44 150.2 0.0 7.4e-44 149.4 0.0 1.5 1 0 0 1 1 1 1 DNA polymerase III, delta subunit DNA_pol3_gamma3 PF12169.8 CAV17928.1 - 3.2e-35 121.1 3.3 6.6e-35 120.1 2.5 2.1 2 0 0 2 2 1 1 DNA polymerase III subunits gamma and tau domain III DNA_pol3_tau_4 PF12168.8 CAV17928.1 - 1.9e-20 73.2 7.7 1.9e-20 73.2 7.7 3.4 4 0 0 4 4 2 1 DNA polymerase III subunits tau domain IV DnaB-binding AAA PF00004.29 CAV17928.1 - 5.3e-10 39.8 0.0 2.1e-09 37.9 0.0 2.0 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 CAV17928.1 - 1.1e-06 28.5 0.1 3.1e-05 23.8 0.0 2.4 1 1 1 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 CAV17928.1 - 7.5e-05 23.0 0.1 0.00052 20.3 0.0 2.4 2 0 0 2 2 2 1 AAA domain ResIII PF04851.15 CAV17928.1 - 0.00014 21.9 1.1 0.15 12.0 0.0 2.7 3 0 0 3 3 3 2 Type III restriction enzyme, res subunit AAA_5 PF07728.14 CAV17928.1 - 0.00017 21.6 0.0 0.0012 18.8 0.0 2.4 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 CAV17928.1 - 0.0015 19.0 4.3 0.008 16.6 1.2 3.5 2 1 0 2 2 2 1 AAA ATPase domain AAA_30 PF13604.6 CAV17928.1 - 0.0015 18.3 0.0 0.0083 15.9 0.0 2.3 2 1 0 2 2 2 1 AAA domain AAA_14 PF13173.6 CAV17928.1 - 0.0036 17.3 0.0 0.011 15.8 0.0 1.8 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.6 CAV17928.1 - 0.0043 17.6 0.0 0.014 15.9 0.0 1.9 1 0 0 1 1 1 1 AAA domain TsaE PF02367.17 CAV17928.1 - 0.029 14.4 0.1 0.081 12.9 0.1 1.7 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE TniB PF05621.11 CAV17928.1 - 0.072 12.5 0.0 0.22 10.9 0.0 1.8 1 0 0 1 1 1 0 Bacterial TniB protein SKI PF01202.22 CAV17928.1 - 0.073 13.2 0.5 0.24 11.5 0.2 2.1 2 0 0 2 2 2 0 Shikimate kinase AAA_7 PF12775.7 CAV17928.1 - 0.16 11.5 0.1 2.8 7.4 0.1 2.3 1 1 0 1 1 1 0 P-loop containing dynein motor region MgtE_N PF03448.17 CAV17928.1 - 0.27 11.9 2.8 9.1 6.9 0.1 3.3 3 0 0 3 3 3 0 MgtE intracellular N domain mono-CXXC PF15626.6 CAV17928.1 - 8.3 6.9 6.9 1.5 9.2 0.9 2.6 2 0 0 2 2 2 0 single CXXC unit YbaB_DNA_bd PF02575.16 CAV17929.1 - 2.7e-35 120.5 10.5 3.1e-35 120.3 10.5 1.0 1 0 0 1 1 1 1 YbaB/EbfC DNA-binding family PspB PF06667.12 CAV17929.1 - 0.0086 16.1 1.4 1.2 9.2 0.1 2.2 2 0 0 2 2 2 2 Phage shock protein B IIGP PF05049.13 CAV17929.1 - 0.093 11.8 0.3 0.14 11.2 0.3 1.2 1 0 0 1 1 1 0 Interferon-inducible GTPase (IIGP) DUF3602 PF12223.8 CAV17929.1 - 0.19 12.4 2.2 0.18 12.4 0.8 1.8 2 1 0 2 2 2 0 Protein of unknown function (DUF3602) Toprim_4 PF13662.6 CAV17930.1 - 6.1e-24 84.3 0.0 9.7e-24 83.7 0.0 1.3 1 0 0 1 1 1 1 Toprim domain RecR PF02132.15 CAV17930.1 - 2.7e-15 55.7 0.8 5.2e-15 54.7 0.8 1.5 1 0 0 1 1 1 1 RecR protein Toprim PF01751.22 CAV17930.1 - 2.9e-11 43.5 0.0 4.8e-11 42.8 0.0 1.3 1 0 0 1 1 1 1 Toprim domain HHH PF00633.23 CAV17930.1 - 0.037 13.9 0.1 0.33 10.9 0.0 2.5 2 0 0 2 2 2 0 Helix-hairpin-helix motif HHH_5 PF14520.6 CAV17930.1 - 0.06 14.0 0.1 0.64 10.7 0.0 2.4 3 0 0 3 3 3 0 Helix-hairpin-helix domain MIP PF00230.20 CAV17931.1 - 1.2e-48 165.8 19.7 1.4e-48 165.6 19.7 1.0 1 0 0 1 1 1 1 Major intrinsic protein LPAM_2 PF13627.6 CAV17932.1 - 0.41 10.5 5.4 0.68 9.9 5.4 1.4 1 0 0 1 1 1 0 Prokaryotic lipoprotein-attachment site LPAM_1 PF08139.12 CAV17932.1 - 0.5 11.0 4.4 0.79 10.3 4.4 1.3 1 0 0 1 1 1 0 Prokaryotic membrane lipoprotein lipid attachment site CxxCxxCC PF03692.15 CAV17934.1 - 0.011 16.4 9.7 0.26 12.0 9.7 2.1 1 1 0 1 1 1 0 Putative zinc- or iron-chelating domain CxxCxxCC PF03692.15 CAV17935.1 - 3e-08 34.3 8.8 5.5e-08 33.4 8.8 1.5 1 0 0 1 1 1 1 Putative zinc- or iron-chelating domain Alk_phosphatase PF00245.20 CAV17936.1 - 7e-87 292.1 3.9 1.6e-85 287.5 3.9 2.1 1 1 0 1 1 1 1 Alkaline phosphatase Metalloenzyme PF01676.18 CAV17936.1 - 1.2e-08 34.7 0.7 7.8e-08 32.0 0.0 2.3 2 1 0 2 2 2 1 Metalloenzyme superfamily Sulfatase PF00884.23 CAV17936.1 - 0.00023 20.7 0.5 0.0016 17.9 0.5 2.6 1 1 0 1 1 1 1 Sulfatase Methyltransf_32 PF13679.6 CAV17936.1 - 0.013 15.5 0.5 0.023 14.7 0.1 1.7 2 0 0 2 2 2 0 Methyltransferase domain Rsc14 PF08586.10 CAV17936.1 - 0.12 13.2 0.5 0.44 11.4 0.0 2.2 2 0 0 2 2 2 0 RSC complex, Rsc14/Ldb7 subunit BCCT PF02028.17 CAV17937.1 - 8.3e-160 532.4 37.8 9.8e-160 532.2 37.8 1.0 1 0 0 1 1 1 1 BCCT, betaine/carnitine/choline family transporter TadF PF16964.5 CAV17937.1 - 0.46 10.2 1.9 0.44 10.3 0.2 1.7 2 0 0 2 2 2 0 Putative tight adherence pilin protein F Spc7 PF08317.11 CAV17937.1 - 0.68 8.8 7.2 0.95 8.3 7.2 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein FtsL PF04999.13 CAV17938.1 - 0.027 14.4 0.0 0.048 13.7 0.0 1.4 1 1 0 1 1 1 0 Cell division protein FtsL APG6_N PF17675.1 CAV17938.1 - 0.052 14.1 2.2 0.072 13.6 2.2 1.1 1 0 0 1 1 1 0 Apg6 coiled-coil region Cofac_haem_bdg PF04187.13 CAV17939.1 - 3.3e-54 184.1 0.6 4.3e-54 183.8 0.6 1.1 1 0 0 1 1 1 1 Haem-binding uptake, Tiki superfamily, ChaN Tis11B_N PF04553.12 CAV17939.1 - 0.086 13.4 0.0 0.18 12.3 0.0 1.5 1 0 0 1 1 1 0 Tis11B like protein, N terminus RRG8 PF17068.5 CAV17939.1 - 0.11 11.9 0.0 0.18 11.2 0.0 1.3 1 0 0 1 1 1 0 Required for respiratory growth protein 8 mitochondrial Methyltransf_31 PF13847.6 CAV17940.1 - 7.8e-13 48.5 0.0 1.3e-12 47.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CAV17940.1 - 1.6e-10 41.5 0.0 4.5e-10 40.1 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 CAV17940.1 - 5.2e-10 39.8 0.0 1.2e-09 38.7 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CAV17940.1 - 4.6e-05 23.3 0.0 0.00034 20.5 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CAV17940.1 - 0.00016 22.4 0.0 0.0004 21.1 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_32 PF13679.6 CAV17940.1 - 0.0017 18.3 0.0 0.0021 18.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 CAV17940.1 - 0.0029 17.0 0.0 0.0043 16.4 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_4 PF02390.17 CAV17940.1 - 0.01 15.3 0.0 0.19 11.1 0.0 2.1 2 0 0 2 2 2 0 Putative methyltransferase MTS PF05175.14 CAV17940.1 - 0.021 14.4 0.0 0.037 13.6 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain DLH PF01738.18 CAV17940.1 - 0.091 12.3 0.0 0.17 11.4 0.0 1.4 1 0 0 1 1 1 0 Dienelactone hydrolase family Cytochrom_CIII PF02085.16 CAV17940.1 - 0.12 12.7 1.1 0.21 11.9 1.1 1.4 1 0 0 1 1 1 0 Class III cytochrome C family Pox_I3 PF04661.12 CAV17940.1 - 0.14 11.3 0.0 0.2 10.8 0.0 1.2 1 0 0 1 1 1 0 Poxvirus I3 ssDNA-binding protein Cache_3-Cache_2 PF17201.4 CAV17941.1 - 1.7e-65 221.2 0.1 1.7e-65 221.2 0.1 4.0 2 1 2 4 4 4 1 Cache 3/Cache 2 fusion domain MCPsignal PF00015.21 CAV17941.1 - 9.1e-43 146.0 49.1 3.5e-42 144.1 27.5 2.7 1 1 1 2 2 2 2 Methyl-accepting chemotaxis protein (MCP) signalling domain sCache_3_3 PF17202.4 CAV17941.1 - 1.1e-27 96.6 4.7 1.1e-27 96.5 0.1 3.0 2 1 0 2 2 2 1 Single cache domain 3 dCache_2 PF08269.11 CAV17941.1 - 8.5e-07 28.4 0.1 8.5e-07 28.4 0.1 3.6 3 1 0 3 3 3 1 Cache domain sCache_2 PF17200.4 CAV17941.1 - 1.7e-05 24.7 0.0 1.7e-05 24.7 0.0 4.0 4 1 1 5 5 5 1 Single Cache domain 2 sCache_3_2 PF17203.4 CAV17941.1 - 2.1e-05 24.7 0.0 2.1e-05 24.7 0.0 4.2 3 2 1 4 4 4 1 Single cache domain 3 HAMP PF00672.25 CAV17941.1 - 0.00062 20.1 0.2 0.18 12.2 0.0 4.3 5 1 0 5 5 4 1 HAMP domain DUF948 PF06103.11 CAV17941.1 - 0.005 17.1 45.5 0.032 14.5 11.0 6.9 2 1 4 6 6 6 1 Bacterial protein of unknown function (DUF948) kleA_kleC PF17383.2 CAV17941.1 - 0.12 12.7 9.1 0.3 11.4 0.2 3.7 2 2 3 5 5 5 0 Uncharacterized KorC regulated protein A GAPT PF11770.8 CAV17941.1 - 0.18 11.7 0.0 0.18 11.7 0.0 2.7 3 1 0 3 3 3 0 GRB2-binding adapter (GAPT) Dicistro_VP4 PF11492.8 CAV17941.1 - 0.21 11.6 1.0 1.9 8.5 0.1 2.9 2 0 0 2 2 2 0 Cricket paralysis virus, VP4 Prominin PF05478.11 CAV17941.1 - 0.79 7.6 26.7 0.0081 14.2 9.8 2.3 2 0 0 2 2 2 0 Prominin Fib_alpha PF08702.10 CAV17941.1 - 0.9 9.7 35.3 0.51 10.5 10.4 3.8 3 2 0 4 4 3 0 Fibrinogen alpha/beta chain family Tweety PF04906.13 CAV17941.1 - 3.4 6.2 22.0 0.96 8.0 5.9 3.1 2 1 1 3 3 3 0 Tweety Hormone_1 PF00103.20 CAV17941.1 - 4.5 7.0 13.8 1.9 8.2 1.6 3.0 2 1 1 3 3 3 0 Somatotropin hormone family Neur_chan_memb PF02932.16 CAV17941.1 - 4.8 7.2 10.9 1.3 9.0 0.3 2.3 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region Laminin_II PF06009.12 CAV17941.1 - 5.4 7.0 44.3 0.74 9.8 7.6 4.1 2 2 2 4 4 4 0 Laminin Domain II Vip3A_N PF12495.8 CAV17941.1 - 7.1 6.5 14.0 0.053 13.4 1.8 2.9 2 1 1 3 3 3 0 Vegetative insecticide protein 3A N terminal NRBF2_MIT PF17169.4 CAV17941.1 - 7.1 6.9 9.7 0.36 11.1 3.8 1.9 2 0 0 2 2 1 0 MIT domain of nuclear receptor-binding factor 2 IFT57 PF10498.9 CAV17941.1 - 9.2 5.1 30.6 0.12 11.3 7.7 3.0 2 1 1 3 3 3 0 Intra-flagellar transport protein 57 Aldose_epim PF01263.20 CAV17944.1 - 1.6e-51 175.4 0.1 1.9e-51 175.1 0.1 1.1 1 0 0 1 1 1 1 Aldose 1-epimerase DUF11 PF01345.18 CAV17944.1 - 0.00082 19.6 0.0 0.78 10.1 0.0 2.7 2 0 0 2 2 2 2 Domain of unknown function DUF11 DUF4352 PF11611.8 CAV17944.1 - 0.02 15.2 0.1 0.083 13.2 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4352) Gp_dh_C PF02800.20 CAV17946.1 - 4.7e-68 227.7 0.1 6.7e-68 227.2 0.1 1.2 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain Gp_dh_N PF00044.24 CAV17946.1 - 6.3e-40 135.6 1.4 1.2e-39 134.7 0.4 1.9 2 0 0 2 2 2 1 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain DapB_N PF01113.20 CAV17946.1 - 0.0024 18.0 4.0 0.015 15.4 1.4 2.9 2 1 0 2 2 2 1 Dihydrodipicolinate reductase, N-terminus 2-Hacid_dh_C PF02826.19 CAV17946.1 - 0.023 14.0 0.1 0.044 13.1 0.1 1.4 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain SelR PF01641.18 CAV17948.1 - 2.1e-51 173.1 0.2 2.4e-51 172.9 0.2 1.0 1 0 0 1 1 1 1 SelR domain HECT_2 PF09814.9 CAV17948.1 - 0.045 12.6 0.3 1.7 7.4 0.0 2.0 2 0 0 2 2 2 0 HECT-like Ubiquitin-conjugating enzyme (E2)-binding DUF2989 PF11207.8 CAV17949.1 - 2.8e-74 249.2 4.4 3.4e-74 249.0 4.4 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2989) DUF1315 PF07023.12 CAV17950.1 - 1.2e-30 105.3 0.2 1.4e-30 105.2 0.2 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1315) Asparaginase PF00710.20 CAV17951.1 - 1.4e-65 220.5 0.0 2.1e-65 219.8 0.0 1.2 1 0 0 1 1 1 1 Asparaginase, N-terminal Asparaginase_C PF17763.1 CAV17951.1 - 4.8e-29 100.9 0.1 7.6e-29 100.2 0.1 1.3 1 0 0 1 1 1 1 Glutaminase/Asparaginase C-terminal domain Peptidase_S49 PF01343.18 CAV17952.1 - 5.2e-79 263.6 0.1 1.4e-46 158.2 0.0 2.3 2 0 0 2 2 2 2 Peptidase family S49 CLP_protease PF00574.23 CAV17952.1 - 1.7e-05 24.8 1.1 0.0052 16.7 0.1 2.8 3 0 0 3 3 3 2 Clp protease SDH_sah PF01972.16 CAV17952.1 - 0.00013 21.0 0.1 0.00028 20.0 0.0 1.5 2 0 0 2 2 2 1 Serine dehydrogenase proteinase MR_MLE_C PF13378.6 CAV17952.1 - 0.015 14.9 0.0 0.024 14.2 0.0 1.3 1 0 0 1 1 1 0 Enolase C-terminal domain-like DUF3247 PF11607.8 CAV17952.1 - 0.13 12.5 0.1 29 5.0 0.0 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3247) Yae1_N PF09811.9 CAV17952.1 - 0.14 11.9 0.1 0.32 10.7 0.1 1.6 1 0 0 1 1 1 0 Essential protein Yae1, N terminal Oxidored_FMN PF00724.20 CAV17953.1 - 3.9e-86 289.4 0.0 5.3e-86 289.0 0.0 1.1 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family Pyr_redox_2 PF07992.14 CAV17953.1 - 2.1e-25 89.6 0.2 4.3e-25 88.5 0.2 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 CAV17953.1 - 8.9e-12 45.1 0.6 2.6e-11 43.6 0.0 2.1 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.27 CAV17953.1 - 1.5e-10 41.5 1.3 3.5e-05 24.3 0.0 4.1 4 0 0 4 4 4 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 CAV17953.1 - 1.6e-10 40.7 1.9 0.00027 20.3 0.1 3.3 3 1 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 CAV17953.1 - 2.4e-09 36.4 3.4 2.2e-08 33.2 0.2 3.0 3 1 1 4 4 4 1 HI0933-like protein DAO PF01266.24 CAV17953.1 - 5.2e-09 36.2 2.1 8.2e-06 25.6 0.2 3.9 5 0 0 5 5 5 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 CAV17953.1 - 2.1e-07 30.4 0.1 5.3e-07 29.1 0.1 1.7 1 0 0 1 1 1 1 FAD binding domain Amino_oxidase PF01593.24 CAV17953.1 - 4e-07 29.7 0.3 5.3e-06 26.0 0.0 2.6 3 0 0 3 3 3 1 Flavin containing amine oxidoreductase FAD_oxidored PF12831.7 CAV17953.1 - 7e-07 28.9 0.0 1.1e-06 28.3 0.0 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase Thi4 PF01946.17 CAV17953.1 - 3.6e-06 26.4 0.1 5.8e-05 22.4 0.0 2.3 2 0 0 2 2 2 1 Thi4 family FAD_binding_3 PF01494.19 CAV17953.1 - 6e-06 25.7 0.9 0.0002 20.7 0.1 2.3 2 0 0 2 2 2 1 FAD binding domain GIDA PF01134.22 CAV17953.1 - 2.9e-05 23.3 0.2 8.3e-05 21.8 0.0 1.9 2 0 0 2 2 2 1 Glucose inhibited division protein A ApbA PF02558.16 CAV17953.1 - 0.00032 20.4 0.1 0.11 12.1 0.0 2.8 2 0 0 2 2 2 1 Ketopantoate reductase PanE/ApbA 3HCDH_N PF02737.18 CAV17953.1 - 0.00047 20.1 1.8 0.011 15.7 0.0 2.4 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_binding_9 PF13454.6 CAV17953.1 - 0.00052 20.0 1.4 0.02 14.9 0.1 3.5 4 0 0 4 4 4 1 FAD-NAD(P)-binding UDPG_MGDP_dh_N PF03721.14 CAV17953.1 - 0.00055 19.6 0.3 0.02 14.5 0.0 2.4 2 0 0 2 2 2 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain NAD_Gly3P_dh_N PF01210.23 CAV17953.1 - 0.00062 19.8 0.1 0.11 12.5 0.0 2.5 2 0 0 2 2 2 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus ThiF PF00899.21 CAV17953.1 - 0.0043 16.4 0.1 0.41 10.0 0.0 2.4 2 0 0 2 2 2 1 ThiF family TrkA_N PF02254.18 CAV17953.1 - 0.0061 16.8 0.2 0.75 10.1 0.0 3.0 3 0 0 3 3 2 1 TrkA-N domain 2-Hacid_dh_C PF02826.19 CAV17953.1 - 0.0074 15.7 0.2 1.9 7.8 0.1 2.5 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Ldh_1_N PF00056.23 CAV17953.1 - 0.016 15.3 1.1 5.1 7.2 0.0 3.4 3 0 0 3 3 3 0 lactate/malate dehydrogenase, NAD binding domain Lycopene_cycl PF05834.12 CAV17953.1 - 0.019 14.1 1.6 0.032 13.3 0.1 2.0 2 0 0 2 2 2 0 Lycopene cyclase protein Dus PF01207.17 CAV17953.1 - 0.024 13.7 0.0 0.047 12.8 0.0 1.4 1 0 0 1 1 1 0 Dihydrouridine synthase (Dus) MR_MLE_C PF13378.6 CAV17953.1 - 0.091 12.3 0.0 0.71 9.4 0.0 2.4 2 1 0 2 2 2 0 Enolase C-terminal domain-like NAD_binding_7 PF13241.6 CAV17953.1 - 0.12 12.9 1.4 0.63 10.5 0.0 2.6 3 0 0 3 3 2 0 Putative NAD(P)-binding YjeF_N PF03853.15 CAV17953.1 - 0.12 12.2 0.1 0.24 11.3 0.1 1.5 1 0 0 1 1 1 0 YjeF-related protein N-terminus Trp_halogenase PF04820.14 CAV17953.1 - 0.18 10.6 0.2 0.56 9.0 0.1 1.8 2 0 0 2 2 2 0 Tryptophan halogenase Nitroreductase PF00881.24 CAV17955.1 - 5.9e-23 81.8 0.1 7.1e-23 81.5 0.1 1.1 1 0 0 1 1 1 1 Nitroreductase family DUF3549 PF12069.8 CAV17955.1 - 0.026 13.6 0.0 0.033 13.3 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3549) Topoisom_bac PF01131.20 CAV17956.1 - 7.8e-114 380.9 0.0 1e-113 380.5 0.0 1.1 1 0 0 1 1 1 1 DNA topoisomerase Toprim PF01751.22 CAV17956.1 - 1.4e-15 57.3 0.0 4.3e-15 55.8 0.0 1.9 2 0 0 2 2 2 1 Toprim domain DUF3080 PF11279.8 CAV17958.1 - 1.3e-93 313.7 5.7 1.5e-93 313.5 5.7 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3080) adh_short PF00106.25 CAV17959.1 - 1.9e-32 112.3 0.0 2.4e-32 112.0 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CAV17959.1 - 1.2e-26 93.7 0.0 1.5e-26 93.4 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase NAD_binding_10 PF13460.6 CAV17959.1 - 1.8e-08 34.5 0.0 2.3e-08 34.1 0.0 1.1 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 CAV17959.1 - 1.5e-05 24.6 0.0 2.2e-05 24.1 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family KR PF08659.10 CAV17959.1 - 6.4e-05 22.9 0.0 8.6e-05 22.5 0.0 1.2 1 0 0 1 1 1 1 KR domain RmlD_sub_bind PF04321.17 CAV17959.1 - 0.004 16.3 0.0 0.0054 15.9 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain GDP_Man_Dehyd PF16363.5 CAV17959.1 - 0.0052 16.2 0.1 0.0077 15.7 0.1 1.2 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase NmrA PF05368.13 CAV17959.1 - 0.1 12.2 0.0 0.15 11.6 0.0 1.2 1 0 0 1 1 1 0 NmrA-like family Sacchrp_dh_NADP PF03435.18 CAV17959.1 - 0.17 12.2 0.0 0.27 11.5 0.0 1.3 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain Hist_deacetyl PF00850.19 CAV17960.1 - 3e-53 181.3 0.3 4.8e-53 180.6 0.3 1.2 1 0 0 1 1 1 1 Histone deacetylase domain Rrf2 PF02082.20 CAV17962.1 - 7.9e-20 71.0 0.2 1e-19 70.7 0.2 1.1 1 0 0 1 1 1 1 Transcriptional regulator HTH_AraC PF00165.23 CAV17962.1 - 0.011 15.8 0.0 0.02 15.0 0.0 1.5 1 0 0 1 1 1 0 Bacterial regulatory helix-turn-helix proteins, AraC family MarR_2 PF12802.7 CAV17962.1 - 0.035 14.0 0.0 0.086 12.7 0.0 1.7 1 1 0 1 1 1 0 MarR family TrmB PF01978.19 CAV17962.1 - 0.048 13.6 0.0 0.083 12.8 0.0 1.4 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB HTH_36 PF13730.6 CAV17962.1 - 0.11 12.4 0.1 0.3 11.1 0.0 1.8 2 0 0 2 2 2 0 Helix-turn-helix domain NnrS PF05940.12 CAV17963.1 - 2.5e-106 356.2 63.7 2.8e-106 356.0 63.7 1.0 1 0 0 1 1 1 1 NnrS protein SelP_N PF04592.14 CAV17964.1 - 0.03 13.7 1.3 0.031 13.7 1.3 1.0 1 0 0 1 1 1 0 Selenoprotein P, N terminal region CHD5 PF04420.14 CAV17964.1 - 0.039 13.8 0.0 0.045 13.6 0.0 1.0 1 0 0 1 1 1 0 CHD5-like protein Peroxin-13_N PF04088.13 CAV17964.1 - 0.084 13.1 0.1 0.089 13.1 0.1 1.0 1 0 0 1 1 1 0 Peroxin 13, N-terminal region DUF3413 PF11893.8 CAV17965.1 - 8.7e-100 333.0 12.6 1.2e-99 332.5 12.6 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3413) Sulfatase PF00884.23 CAV17965.1 - 3.5e-15 56.2 3.8 7.4e-14 51.8 3.8 2.3 1 1 0 1 1 1 1 Sulfatase DUF229 PF02995.17 CAV17965.1 - 0.00096 17.9 0.0 0.0016 17.2 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF229) Phosphodiest PF01663.22 CAV17965.1 - 0.0079 15.8 0.0 0.012 15.2 0.0 1.4 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase DUF1414 PF07208.11 CAV17967.1 - 6.9e-21 74.0 0.4 9.3e-21 73.5 0.4 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1414) DUF5584 PF17822.1 CAV17967.1 - 0.054 13.0 0.0 0.058 12.9 0.0 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5584) NA37 PF04245.13 CAV17968.1 - 8.9e-96 321.0 2.2 1e-95 320.8 2.2 1.0 1 0 0 1 1 1 1 37-kD nucleoid-associated bacterial protein DUF5392 PF17370.2 CAV17968.1 - 0.07 13.2 0.0 0.13 12.3 0.0 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5392) Hpt PF01627.23 CAV17970.1 - 7.7e-09 35.7 1.7 1.7e-08 34.6 0.3 2.3 2 0 0 2 2 2 1 Hpt domain RPW8 PF05659.11 CAV17970.1 - 0.00058 19.6 0.9 0.0071 16.0 0.3 2.6 2 0 0 2 2 2 1 Arabidopsis broad-spectrum mildew resistance protein RPW8 TerB PF05099.13 CAV17970.1 - 0.0055 16.7 0.6 0.015 15.3 0.1 2.0 2 0 0 2 2 2 1 Tellurite resistance protein TerB TauD PF02668.16 CAV17970.1 - 0.029 14.2 0.2 0.08 12.7 0.0 1.8 2 0 0 2 2 2 0 Taurine catabolism dioxygenase TauD, TfdA family Ninjurin PF04923.12 CAV17970.1 - 0.03 14.3 0.3 0.28 11.1 0.4 2.3 2 0 0 2 2 2 0 Ninjurin DUF3328 PF11807.8 CAV17970.1 - 0.045 13.5 0.3 0.13 12.1 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF3328) Enkurin PF13864.6 CAV17970.1 - 0.12 12.8 3.5 13 6.3 0.2 3.5 3 0 0 3 3 3 0 Calmodulin-binding CcmD PF04995.14 CAV17970.1 - 0.45 10.6 0.0 0.45 10.6 0.0 2.2 2 0 0 2 2 2 0 Heme exporter protein D (CcmD) BRCC36_C PF18110.1 CAV17971.1 - 0.00087 19.4 1.2 0.003 17.7 1.2 1.9 1 0 0 1 1 1 1 BRCC36 C-terminal helical domain DUF2046 PF09755.9 CAV17971.1 - 0.0018 17.6 2.1 0.0035 16.6 2.1 1.5 1 0 0 1 1 1 1 Uncharacterized conserved protein H4 (DUF2046) Allexi_40kDa PF05549.11 CAV17971.1 - 0.11 12.0 0.6 0.24 10.9 0.5 1.6 1 1 0 1 1 1 0 Allexivirus 40kDa protein DUF4756 PF15948.5 CAV17971.1 - 0.13 12.1 4.0 6.3 6.6 0.6 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4756) DUF2605 PF10792.9 CAV17971.1 - 0.22 11.5 2.4 0.35 10.8 0.6 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2605) Baculo_PEP_C PF04513.12 CAV17971.1 - 0.24 11.5 2.1 0.46 10.5 2.1 1.6 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus Na_H_antiporter PF03553.14 CAV17972.1 - 5.7e-67 226.1 42.9 1.6e-64 218.1 23.5 2.0 1 1 1 2 2 2 2 Na+/H+ antiporter family DcuC PF03606.15 CAV17972.1 - 5e-08 31.8 26.4 3.8e-06 25.6 14.6 2.2 2 0 0 2 2 2 2 C4-dicarboxylate anaerobic carrier DXP_synthase_N PF13292.6 CAV17972.1 - 0.1 11.8 0.0 0.18 11.0 0.0 1.3 1 0 0 1 1 1 0 1-deoxy-D-xylulose-5-phosphate synthase Tom7 PF08038.12 CAV17972.1 - 0.14 11.8 4.7 0.49 10.1 0.5 2.8 2 0 0 2 2 2 0 TOM7 family Semialdhyde_dhC PF02774.18 CAV17973.1 - 8.9e-57 192.1 0.0 1.1e-56 191.8 0.0 1.1 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, dimerisation domain Semialdhyde_dh PF01118.24 CAV17973.1 - 1.3e-21 77.3 0.0 2.5e-21 76.4 0.0 1.5 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain Ion_trans PF00520.31 CAV17975.1 - 9.2e-32 110.2 12.1 1.2e-31 109.9 12.1 1.1 1 0 0 1 1 1 1 Ion transport protein Ion_trans_2 PF07885.16 CAV17975.1 - 1.2e-14 54.0 7.6 1.2e-14 54.0 7.6 2.4 2 0 0 2 2 2 1 Ion channel PKD_channel PF08016.12 CAV17975.1 - 0.006 15.3 7.9 0.038 12.7 3.7 2.1 1 1 1 2 2 2 2 Polycystin cation channel DZR PF12773.7 CAV17975.1 - 0.01 15.8 1.0 0.018 15.1 1.0 1.3 1 0 0 1 1 1 0 Double zinc ribbon zf-RING_7 PF02591.15 CAV17975.1 - 0.011 15.9 0.1 0.011 15.9 0.1 1.7 2 0 0 2 2 1 0 C4-type zinc ribbon domain SEO_N PF14576.6 CAV17975.1 - 0.016 14.4 0.1 0.3 10.2 0.0 2.1 2 0 0 2 2 2 0 Sieve element occlusion N-terminus zf-ribbon_3 PF13248.6 CAV17975.1 - 0.023 14.1 1.7 0.037 13.4 1.7 1.3 1 0 0 1 1 1 0 zinc-ribbon domain IBR PF01485.21 CAV17975.1 - 0.049 13.9 1.2 0.084 13.1 1.2 1.3 1 0 0 1 1 1 0 IBR domain, a half RING-finger domain HypA PF01155.19 CAV17975.1 - 0.081 13.0 0.1 0.14 12.2 0.1 1.3 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA DUF2985 PF11204.8 CAV17975.1 - 0.11 12.7 2.3 0.67 10.1 0.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2985) zinc_ribbon_2 PF13240.6 CAV17975.1 - 0.14 11.9 2.5 0.27 11.0 2.5 1.5 1 0 0 1 1 1 0 zinc-ribbon domain Ribosomal_S27e PF01667.17 CAV17975.1 - 0.16 11.7 0.3 0.37 10.5 0.3 1.6 1 0 0 1 1 1 0 Ribosomal protein S27 zf-C2HC_2 PF13913.6 CAV17975.1 - 0.26 11.2 0.2 0.26 11.2 0.2 1.7 2 0 0 2 2 1 0 zinc-finger of a C2HC-type PhnA_Zn_Ribbon PF08274.12 CAV17975.1 - 2.7 8.0 6.5 26 4.9 6.5 2.1 1 1 0 1 1 1 0 PhnA Zinc-Ribbon MarC PF01914.17 CAV17976.1 - 2.6e-66 222.9 11.3 2.9e-66 222.7 11.3 1.0 1 0 0 1 1 1 1 MarC family integral membrane protein TerC PF03741.16 CAV17976.1 - 5.2e-06 26.3 3.1 2.1e-05 24.3 3.1 2.0 1 1 0 1 1 1 1 Integral membrane protein TerC family LysE PF01810.18 CAV17976.1 - 0.0063 16.0 7.2 0.085 12.3 7.1 2.2 1 1 0 1 1 1 1 LysE type translocator RseC_MucC PF04246.12 CAV17976.1 - 0.078 12.9 2.4 2.3 8.2 0.0 2.4 2 0 0 2 2 2 0 Positive regulator of sigma(E), RseC/MucC PNTB_4TM PF12769.7 CAV17976.1 - 0.2 12.1 8.3 4.6 7.8 0.6 2.7 2 1 0 2 2 2 0 4TM region of pyridine nucleotide transhydrogenase, mitoch DUF975 PF06161.11 CAV17976.1 - 1.4 8.7 9.2 0.052 13.3 3.4 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF975) DUF3087 PF11286.8 CAV17976.1 - 2.7 7.4 6.4 12 5.3 0.3 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF3087) Fe-ADH PF00465.19 CAV17978.1 - 5e-114 380.9 0.2 1e-113 379.9 0.1 1.6 2 0 0 2 2 2 1 Iron-containing alcohol dehydrogenase Aldedh PF00171.22 CAV17978.1 - 3e-24 85.4 4.6 9.1e-24 83.8 4.6 1.7 1 1 0 1 1 1 1 Aldehyde dehydrogenase family Fe-ADH_2 PF13685.6 CAV17978.1 - 2.2e-18 66.9 1.3 8.5e-08 32.2 0.3 3.2 3 0 0 3 3 3 2 Iron-containing alcohol dehydrogenase CbiG_N PF11760.8 CAV17978.1 - 0.06 13.4 0.4 0.22 11.6 0.4 2.0 1 0 0 1 1 1 0 Cobalamin synthesis G N-terminal adh_short PF00106.25 CAV17979.1 - 3e-15 56.2 0.0 5.1e-15 55.4 0.0 1.3 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CAV17979.1 - 7.7e-10 38.7 0.0 1e-09 38.3 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Ribosomal_S4Pg PF11993.8 CAV17980.1 - 7.2e-66 221.3 1.4 8.2e-66 221.1 1.4 1.0 1 0 0 1 1 1 1 Ribosomal S4P (gammaproteobacterial) Sod_Fe_C PF02777.18 CAV17981.1 - 3.2e-39 133.2 0.7 8.9e-39 131.8 0.2 1.8 2 0 0 2 2 2 1 Iron/manganese superoxide dismutases, C-terminal domain Sod_Fe_N PF00081.22 CAV17981.1 - 2.1e-34 117.8 0.6 4e-34 116.9 0.6 1.5 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, alpha-hairpin domain Glutaredoxin PF00462.24 CAV17983.1 - 6.1e-17 61.6 0.0 8.5e-17 61.1 0.0 1.2 1 0 0 1 1 1 1 Glutaredoxin Thioredoxin_5 PF13743.6 CAV17984.1 - 5.4e-20 71.8 0.0 6.7e-20 71.6 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin DSBA PF01323.20 CAV17984.1 - 1.9e-13 50.6 0.0 2.3e-13 50.4 0.0 1.1 1 0 0 1 1 1 1 DSBA-like thioredoxin domain Thioredoxin_4 PF13462.6 CAV17984.1 - 0.0072 16.5 0.1 0.019 15.1 0.0 1.7 2 0 0 2 2 2 1 Thioredoxin SICA_alpha PF12887.7 CAV17984.1 - 0.053 13.4 0.1 0.099 12.5 0.0 1.5 1 1 0 1 1 1 0 SICA extracellular alpha domain Thioredoxin PF00085.20 CAV17984.1 - 0.06 13.3 0.1 2.8 8.0 0.0 2.4 2 0 0 2 2 2 0 Thioredoxin SBP_bac_3 PF00497.20 CAV17985.1 - 1.8e-56 191.1 0.0 1e-29 103.6 0.0 3.4 3 0 0 3 3 3 2 Bacterial extracellular solute-binding proteins, family 3 HATPase_c PF02518.26 CAV17985.1 - 1.1e-30 106.4 0.4 7.9e-30 103.7 0.7 2.3 3 0 0 3 3 3 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 CAV17985.1 - 3e-22 78.9 0.8 3.2e-21 75.6 0.2 3.0 2 0 0 2 2 2 1 Response regulator receiver domain HisKA PF00512.25 CAV17985.1 - 4.9e-19 68.1 0.5 1.9e-18 66.2 0.5 2.2 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain PAS_3 PF08447.12 CAV17985.1 - 3.5e-09 36.8 0.0 9.7e-09 35.4 0.0 1.8 1 0 0 1 1 1 1 PAS fold Hpt PF01627.23 CAV17985.1 - 6e-05 23.2 0.4 6e-05 23.2 0.4 2.9 3 0 0 3 3 3 1 Hpt domain Lig_chan-Glu_bd PF10613.9 CAV17985.1 - 0.00012 22.3 0.6 0.23 11.6 0.0 3.9 3 1 0 3 3 3 1 Ligated ion channel L-glutamate- and glycine-binding site HATPase_c_5 PF14501.6 CAV17985.1 - 0.00026 20.8 0.1 0.0012 18.8 0.1 2.3 1 0 0 1 1 1 1 GHKL domain HATPase_c_3 PF13589.6 CAV17985.1 - 0.0034 17.2 0.0 0.0091 15.8 0.0 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 CAV17986.1 - 1.3e-16 60.8 0.0 2.9e-16 59.6 0.0 1.6 1 0 0 1 1 1 1 Response regulator receiver domain TPR_19 PF14559.6 CAV17986.1 - 7e-09 36.1 2.9 0.015 15.8 0.7 4.5 2 1 3 5 5 5 4 Tetratricopeptide repeat ANAPC3 PF12895.7 CAV17986.1 - 0.0019 18.4 1.2 6.5 7.1 0.1 3.6 2 1 1 3 3 3 2 Anaphase-promoting complex, cyclosome, subunit 3 Coatomer_E PF04733.14 CAV17986.1 - 0.0054 16.2 4.7 0.0064 15.9 2.0 2.3 2 1 1 3 3 3 1 Coatomer epsilon subunit TPR_17 PF13431.6 CAV17986.1 - 0.01 16.2 0.1 7.3 7.2 0.0 3.2 2 0 0 2 2 2 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 CAV17986.1 - 0.02 15.0 0.1 0.29 11.3 0.0 2.8 2 1 1 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat NARP1 PF12569.8 CAV17986.1 - 0.029 13.3 0.2 0.045 12.7 0.2 1.3 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 TPR_6 PF13174.6 CAV17986.1 - 0.03 15.0 0.5 9.3 7.1 0.0 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_14 PF13428.6 CAV17986.1 - 0.089 13.7 0.0 15 6.7 0.0 3.9 2 1 2 4 4 4 0 Tetratricopeptide repeat Na_H_antiporter PF03553.14 CAV17987.1 - 6.2e-76 255.5 24.7 6.2e-76 255.5 24.7 2.4 2 1 1 3 3 3 1 Na+/H+ antiporter family Na_H_antiport_2 PF13726.6 CAV17987.1 - 3.8e-33 113.5 10.4 3.8e-33 113.5 10.4 3.7 4 0 0 4 4 4 2 Na+-H+ antiporter family CitMHS PF03600.16 CAV17987.1 - 2.4e-11 43.4 51.0 5.8e-10 38.8 49.9 2.1 1 1 1 2 2 2 2 Citrate transporter DctM PF06808.12 CAV17987.1 - 1.8e-10 40.3 22.3 1.8e-10 40.3 22.3 2.1 1 1 1 2 2 2 1 Tripartite ATP-independent periplasmic transporter, DctM component GntP_permease PF02447.16 CAV17987.1 - 0.0017 17.1 18.9 0.0017 17.1 18.9 2.8 1 1 1 2 2 2 1 GntP family permease HERV-K_REC PF15695.5 CAV17987.1 - 1.7 8.8 6.0 8.7 6.5 0.0 3.5 3 0 0 3 3 3 0 Rec (regulator of expression encoded by corf) of HERV-K-113 RNase_T PF00929.24 CAV17988.1 - 1.3e-42 146.1 0.2 1.7e-42 145.8 0.2 1.1 1 0 0 1 1 1 1 Exonuclease SCAPER_N PF16501.5 CAV17988.1 - 0.012 15.7 0.0 0.023 14.7 0.0 1.4 1 0 0 1 1 1 0 S phase cyclin A-associated protein in the endoplasmic reticulum MotY_N PF18393.1 CAV17990.1 - 8.1e-51 172.0 0.0 1.1e-50 171.6 0.0 1.2 1 0 0 1 1 1 1 MotY N-terminal domain OmpA PF00691.20 CAV17990.1 - 4.8e-20 71.7 0.3 7.1e-20 71.2 0.3 1.2 1 0 0 1 1 1 1 OmpA family Pilus_CpaD PF09476.10 CAV17990.1 - 0.058 13.1 0.0 0.088 12.5 0.0 1.2 1 0 0 1 1 1 0 Pilus biogenesis CpaD protein (pilus_cpaD) Ras PF00071.22 CAV17990.1 - 0.18 11.4 0.1 0.26 10.9 0.1 1.2 1 0 0 1 1 1 0 Ras family DUF2753 PF10952.8 CAV17992.1 - 1.6e-74 248.6 1.6 1.8e-74 248.5 1.6 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2753) TPR_2 PF07719.17 CAV17992.1 - 0.002 18.1 0.1 0.049 13.8 0.0 2.5 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_1 PF00515.28 CAV17992.1 - 0.013 15.2 0.0 0.19 11.6 0.0 2.5 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_7 PF13176.6 CAV17992.1 - 0.031 14.3 0.1 3.6 7.8 0.1 2.8 3 0 0 3 3 3 0 Tetratricopeptide repeat Glyoxalase PF00903.25 CAV17993.1 - 2e-23 83.0 0.1 2.3e-23 82.8 0.1 1.0 1 0 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_4 PF13669.6 CAV17993.1 - 1.2e-13 51.3 0.1 3.8e-09 36.8 0.0 2.0 1 1 1 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_6 PF18029.1 CAV17993.1 - 9.5e-05 23.1 0.0 0.00018 22.2 0.0 1.5 1 1 0 1 1 1 1 Glyoxalase-like domain CppA_N PF14506.6 CAV17993.1 - 0.04 14.0 0.0 0.062 13.4 0.0 1.4 1 0 0 1 1 1 0 CppA N-terminal Glyoxalase_3 PF13468.6 CAV17993.1 - 0.042 13.9 0.0 5.5 7.1 0.0 2.1 2 0 0 2 2 2 0 Glyoxalase-like domain Glyoxalase_2 PF12681.7 CAV17993.1 - 0.078 12.9 0.0 0.14 12.1 0.0 1.4 1 1 0 1 1 1 0 Glyoxalase-like domain HhH-GPD PF00730.25 CAV17995.1 - 3.9e-18 65.9 0.0 6.3e-18 65.2 0.0 1.3 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein HHH PF00633.23 CAV17995.1 - 1.7e-07 30.8 0.0 3.4e-07 29.8 0.0 1.6 1 0 0 1 1 1 1 Helix-hairpin-helix motif EndIII_4Fe-2S PF10576.9 CAV17995.1 - 5.1e-05 23.5 3.3 8e-05 22.9 3.3 1.3 1 0 0 1 1 1 1 Iron-sulfur binding domain of endonuclease III HHH_5 PF14520.6 CAV17995.1 - 0.13 12.9 0.0 0.37 11.4 0.0 1.8 1 0 0 1 1 1 0 Helix-hairpin-helix domain Rnf-Nqr PF02508.14 CAV17996.1 - 7.8e-64 214.8 11.6 8.9e-64 214.6 11.6 1.0 1 0 0 1 1 1 1 Rnf-Nqr subunit, membrane protein PHO4 PF01384.20 CAV17996.1 - 3.1 6.8 7.2 4.9 6.1 7.2 1.5 1 1 0 1 1 1 0 Phosphate transporter family FMN_bind PF04205.14 CAV17998.1 - 5.2e-20 71.8 0.1 8.2e-20 71.2 0.1 1.3 1 0 0 1 1 1 1 FMN-binding domain Peptidase_C70 PF12385.8 CAV17998.1 - 0.0029 17.6 0.1 0.0088 16.0 0.1 1.7 1 1 0 1 1 1 1 Papain-like cysteine protease AvrRpt2 NQR2_RnfD_RnfE PF03116.15 CAV17999.1 - 1.1e-104 350.0 19.6 1.2e-104 349.8 19.6 1.0 1 0 0 1 1 1 1 NQR2, RnfD, RnfE family SLBB PF10531.9 CAV18000.1 - 3e-09 36.6 0.0 6.8e-09 35.5 0.0 1.6 1 0 0 1 1 1 1 SLBB domain Fer4_7 PF12838.7 CAV18000.1 - 3.8e-08 33.8 8.2 1.6e-07 31.8 8.2 2.2 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4 PF00037.27 CAV18000.1 - 1.5e-07 30.9 13.8 0.0016 18.2 3.7 2.4 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_10 PF13237.6 CAV18000.1 - 7.2e-07 29.2 12.9 2.1e-05 24.6 13.9 2.8 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_8 PF13183.6 CAV18000.1 - 1.1e-06 28.9 22.7 1.3e-05 25.5 11.8 3.8 2 2 1 3 3 2 2 4Fe-4S dicluster domain Fer4_9 PF13187.6 CAV18000.1 - 4.1e-06 26.8 12.7 1.3e-05 25.2 12.7 2.0 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_17 PF13534.6 CAV18000.1 - 1.3e-05 25.6 14.3 0.00028 21.3 14.1 3.3 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_2 PF12797.7 CAV18000.1 - 4.9e-05 23.2 15.4 0.025 14.7 3.5 2.5 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_6 PF12837.7 CAV18000.1 - 0.003 17.6 15.8 0.19 11.9 4.4 2.5 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_16 PF13484.6 CAV18000.1 - 0.003 18.4 13.3 0.0063 17.4 2.5 5.6 6 3 0 6 6 6 2 4Fe-4S double cluster binding domain Fer4_21 PF14697.6 CAV18000.1 - 0.0091 16.1 13.9 0.044 13.9 13.4 2.4 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_3 PF12798.7 CAV18000.1 - 0.028 15.3 15.8 0.91 10.6 3.7 2.4 2 0 0 2 2 2 0 4Fe-4S binding domain DUF963 PF06131.11 CAV18000.1 - 0.029 13.8 5.8 1.9 8.0 0.3 2.9 2 0 0 2 2 2 0 Schizosaccharomyces pombe repeat of unknown function (DUF963) Fer4_22 PF17179.4 CAV18000.1 - 0.05 14.4 0.9 0.05 14.4 0.9 3.7 4 0 0 4 4 2 0 4Fe-4S dicluster domain Fer4_4 PF12800.7 CAV18000.1 - 0.061 13.8 12.0 1.5 9.5 2.0 2.4 2 0 0 2 2 2 0 4Fe-4S binding domain Fer4_18 PF13746.6 CAV18000.1 - 8.9 6.5 25.3 0.06 13.6 1.8 4.5 4 1 1 5 5 5 0 4Fe-4S dicluster domain Complex1_51K PF01512.17 CAV18003.1 - 9.8e-39 132.7 0.2 1.4e-38 132.1 0.2 1.2 1 0 0 1 1 1 1 Respiratory-chain NADH dehydrogenase 51 Kd subunit RnfC_N PF13375.6 CAV18003.1 - 1.8e-34 117.7 0.1 5.4e-34 116.2 0.0 1.8 2 0 0 2 2 2 1 RnfC Barrel sandwich hybrid domain NQRA PF05896.11 CAV18003.1 - 1.7e-05 24.4 0.0 3.8e-05 23.3 0.0 1.5 1 1 0 1 1 1 1 Na(+)-translocating NADH-quinone reductase subunit A (NQRA) Biotin_lipoyl PF00364.22 CAV18003.1 - 0.066 13.1 0.0 0.14 12.0 0.0 1.5 1 0 0 1 1 1 0 Biotin-requiring enzyme Fer4_21 PF14697.6 CAV18005.1 - 9.7e-18 64.1 15.9 9.7e-18 64.1 15.9 2.1 2 0 0 2 2 2 1 4Fe-4S dicluster domain FeS PF04060.13 CAV18005.1 - 1e-14 53.9 5.2 1e-14 53.9 5.2 2.2 2 0 0 2 2 1 1 Putative Fe-S cluster Fer4 PF00037.27 CAV18005.1 - 1.9e-11 43.3 27.8 1.3e-07 31.1 4.6 3.4 3 0 0 3 3 3 2 4Fe-4S binding domain Fer4_7 PF12838.7 CAV18005.1 - 2.2e-08 34.5 18.4 0.001 19.6 8.8 2.7 2 1 0 2 2 2 2 4Fe-4S dicluster domain Fer4_9 PF13187.6 CAV18005.1 - 8.1e-08 32.3 33.8 1.1e-06 28.6 15.0 2.5 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_10 PF13237.6 CAV18005.1 - 1.6e-06 28.1 13.6 1.6e-06 28.1 13.6 3.2 2 2 1 3 3 3 2 4Fe-4S dicluster domain Fer4_16 PF13484.6 CAV18005.1 - 3.5e-06 27.9 18.7 0.00025 21.9 2.0 3.1 3 0 0 3 3 3 2 4Fe-4S double cluster binding domain Fer4_2 PF12797.7 CAV18005.1 - 3e-05 23.8 21.6 8.1e-05 22.5 2.3 3.4 3 0 0 3 3 3 2 4Fe-4S binding domain Fer4_6 PF12837.7 CAV18005.1 - 3.6e-05 23.7 4.8 3.6e-05 23.7 4.8 3.4 3 0 0 3 3 3 2 4Fe-4S binding domain Fer4_22 PF17179.4 CAV18005.1 - 0.0054 17.6 11.6 0.0059 17.4 0.1 2.6 3 0 0 3 3 2 2 4Fe-4S dicluster domain Fer4_3 PF12798.7 CAV18005.1 - 0.0069 17.2 4.7 0.0069 17.2 4.7 3.9 4 0 0 4 4 4 1 4Fe-4S binding domain Fer4_4 PF12800.7 CAV18005.1 - 0.027 15.0 26.6 0.073 13.6 3.3 3.5 3 0 0 3 3 3 0 4Fe-4S binding domain Fer4_17 PF13534.6 CAV18005.1 - 0.035 14.7 20.4 0.7 10.5 8.1 2.8 1 1 1 3 3 3 0 4Fe-4S dicluster domain BPD_transp_2 PF02653.16 CAV18005.1 - 0.17 11.0 2.5 0.22 10.6 2.5 1.1 1 0 0 1 1 1 0 Branched-chain amino acid transport system / permease component Fer4_18 PF13746.6 CAV18005.1 - 0.55 10.5 15.6 2.4 8.4 3.2 2.4 1 1 1 2 2 2 0 4Fe-4S dicluster domain EpuA PF11772.8 CAV18005.1 - 0.89 9.3 5.4 1.6 8.5 5.4 1.4 1 0 0 1 1 1 0 DNA-directed RNA polymerase subunit beta Fer4_8 PF13183.6 CAV18005.1 - 1 9.9 22.4 0.54 10.8 2.8 2.8 1 1 3 4 4 4 0 4Fe-4S dicluster domain Rnf-Nqr PF02508.14 CAV18008.1 - 5.2e-61 205.6 22.6 5.8e-61 205.5 22.6 1.0 1 0 0 1 1 1 1 Rnf-Nqr subunit, membrane protein UvrB_inter PF17757.1 CAV18011.1 - 2.7e-31 107.6 0.0 1e-30 105.7 0.0 2.1 1 0 0 1 1 1 1 UvrB interaction domain UvrB PF12344.8 CAV18011.1 - 4.4e-21 74.5 2.4 1e-20 73.3 1.5 2.2 2 0 0 2 2 2 1 Ultra-violet resistance protein B Helicase_C PF00271.31 CAV18011.1 - 2.1e-18 66.7 0.1 8.7e-18 64.7 0.1 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 CAV18011.1 - 3.1e-10 40.3 0.9 3.9e-08 33.5 0.0 3.1 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit UVR PF02151.19 CAV18011.1 - 2.3e-09 36.7 7.1 1.2e-08 34.5 7.1 2.3 1 0 0 1 1 1 1 UvrB/uvrC motif DEAD PF00270.29 CAV18011.1 - 0.00027 20.7 1.0 0.0036 17.1 0.0 3.3 4 1 0 4 4 4 1 DEAD/DEAH box helicase AAA_30 PF13604.6 CAV18011.1 - 0.00071 19.3 0.0 0.0068 16.1 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.6 CAV18011.1 - 0.0035 17.7 0.0 2.5 8.4 0.0 2.8 2 1 0 2 2 2 2 AAA domain PhageP22-tail PF09251.10 CAV18011.1 - 0.17 10.2 0.0 0.25 9.6 0.0 1.2 1 0 0 1 1 1 0 Salmonella phage P22 tail-spike UvrD-helicase PF00580.21 CAV18011.1 - 0.2 11.1 8.2 0.65 9.5 2.6 2.7 3 0 0 3 3 3 0 UvrD/REP helicase N-terminal domain eIF3_p135 PF12807.7 CAV18011.1 - 1.5 8.8 4.0 18 5.3 0.0 2.6 2 1 0 2 2 2 0 Translation initiation factor eIF3 subunit 135 DUF87 PF01935.17 CAV18011.1 - 9.6 6.2 8.6 2.5 8.1 0.1 3.4 4 0 0 4 4 4 0 Helicase HerA, central domain Sigma54_activat PF00158.26 CAV18013.1 - 1.5e-69 233.0 0.0 2.1e-69 232.5 0.0 1.2 1 0 0 1 1 1 1 Sigma-54 interaction domain Sigma54_activ_2 PF14532.6 CAV18013.1 - 3.4e-27 95.2 0.0 7.4e-27 94.2 0.0 1.6 1 1 0 1 1 1 1 Sigma-54 interaction domain Response_reg PF00072.24 CAV18013.1 - 1.9e-23 82.7 0.0 3.9e-23 81.7 0.0 1.6 1 0 0 1 1 1 1 Response regulator receiver domain HTH_8 PF02954.19 CAV18013.1 - 3.1e-11 42.8 0.0 6.4e-11 41.9 0.0 1.6 1 0 0 1 1 1 1 Bacterial regulatory protein, Fis family AAA_5 PF07728.14 CAV18013.1 - 8.2e-06 25.9 0.0 1.5e-05 25.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.21 CAV18013.1 - 7.8e-05 22.1 0.0 0.069 12.5 0.0 2.3 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA PF00004.29 CAV18013.1 - 0.00074 20.0 0.0 0.002 18.6 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 CAV18013.1 - 0.006 17.0 0.0 0.01 16.2 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain HTH_23 PF13384.6 CAV18013.1 - 0.0087 15.8 0.0 0.021 14.6 0.0 1.6 1 0 0 1 1 1 1 Homeodomain-like domain T2SSE PF00437.20 CAV18013.1 - 0.012 14.7 0.1 0.037 13.1 0.0 1.8 2 0 0 2 2 2 0 Type II/IV secretion system protein AAA_2 PF07724.14 CAV18013.1 - 0.014 15.5 0.0 0.031 14.4 0.0 1.6 2 0 0 2 2 1 0 AAA domain (Cdc48 subfamily) TIP49 PF06068.13 CAV18013.1 - 0.023 13.9 0.1 0.72 9.0 0.1 2.2 2 0 0 2 2 2 0 TIP49 P-loop domain HTH_29 PF13551.6 CAV18013.1 - 0.033 14.2 0.0 0.29 11.2 0.0 2.4 2 0 0 2 2 2 0 Winged helix-turn helix AAA_22 PF13401.6 CAV18013.1 - 0.13 12.5 0.0 0.31 11.3 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.6 CAV18013.1 - 0.17 11.6 0.1 0.35 10.6 0.1 1.5 1 0 0 1 1 1 0 AAA domain HTH_28 PF13518.6 CAV18013.1 - 0.18 11.9 0.0 0.41 10.8 0.0 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain Hpt PF01627.23 CAV18015.1 - 1.2e-07 31.9 0.1 1.6e-07 31.5 0.1 1.3 1 0 0 1 1 1 1 Hpt domain UPF0052 PF01933.18 CAV18016.1 - 1e-74 251.5 0.0 1.1e-74 251.3 0.0 1.0 1 0 0 1 1 1 1 Uncharacterised protein family UPF0052 Mob_synth_C PF06463.13 CAV18019.1 - 2.3e-39 134.3 0.0 3.5e-39 133.7 0.0 1.3 1 0 0 1 1 1 1 Molybdenum Cofactor Synthesis C Radical_SAM PF04055.21 CAV18019.1 - 3.9e-27 95.7 0.0 5.9e-27 95.1 0.0 1.3 1 0 0 1 1 1 1 Radical SAM superfamily Fer4_12 PF13353.6 CAV18019.1 - 3.4e-09 37.1 0.0 1.3e-08 35.3 0.0 1.9 2 1 0 2 2 2 1 4Fe-4S single cluster domain Fer4_14 PF13394.6 CAV18019.1 - 0.00031 20.9 0.1 0.0011 19.1 0.0 1.9 2 0 0 2 2 2 1 4Fe-4S single cluster domain AhpC-TSA PF00578.21 CAV18019.1 - 0.0028 17.6 0.0 1.5 8.8 0.0 2.5 2 1 0 2 2 2 2 AhpC/TSA family DUF1272 PF06906.11 CAV18019.1 - 0.015 15.4 0.6 6.2 7.0 0.3 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1272) MoCF_biosynth PF00994.24 CAV18021.1 - 8.1e-34 116.4 0.2 9.6e-34 116.1 0.2 1.0 1 0 0 1 1 1 1 Probable molybdopterin binding domain MoaC PF01967.21 CAV18024.1 - 3.8e-58 195.4 4.7 4.3e-58 195.2 4.7 1.0 1 0 0 1 1 1 1 MoaC family ThiS PF02597.20 CAV18027.1 - 2.2e-22 79.5 0.1 2.4e-22 79.3 0.1 1.0 1 0 0 1 1 1 1 ThiS family MoaE PF02391.17 CAV18028.1 - 8.7e-37 125.9 0.0 1.1e-36 125.6 0.0 1.1 1 0 0 1 1 1 1 MoaE protein SBP_bac_5 PF00496.22 CAV18029.1 - 6.6e-94 314.9 8.7 8e-94 314.7 8.7 1.1 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 5 Middle BPD_transp_1 PF00528.22 CAV18031.1 - 1.7e-40 138.7 19.6 1.7e-40 138.7 19.6 1.7 2 1 0 2 2 2 1 Binding-protein-dependent transport system inner membrane component BPD_transp_1 PF00528.22 CAV18033.1 - 2.9e-27 95.6 10.8 2.9e-27 95.6 10.8 2.1 2 1 0 2 2 2 1 Binding-protein-dependent transport system inner membrane component OppC_N PF12911.7 CAV18033.1 - 1.3e-15 57.1 0.3 1.3e-15 57.1 0.3 3.1 3 1 0 3 3 3 1 N-terminal TM domain of oligopeptide transport permease C Ac76 PF05814.11 CAV18033.1 - 0.018 15.0 0.2 0.018 15.0 0.2 2.6 2 0 0 2 2 2 0 Orf76 (Ac76) ABC_tran PF00005.27 CAV18036.1 - 5.8e-28 98.1 0.0 8.3e-28 97.6 0.0 1.2 1 0 0 1 1 1 1 ABC transporter oligo_HPY PF08352.12 CAV18036.1 - 4.3e-19 68.8 0.1 8.1e-19 67.9 0.1 1.5 1 0 0 1 1 1 1 Oligopeptide/dipeptide transporter, C-terminal region AAA_21 PF13304.6 CAV18036.1 - 7.2e-07 29.3 1.0 2.5e-06 27.5 0.0 2.0 1 1 1 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 CAV18036.1 - 5.7e-06 25.9 0.1 8.3e-06 25.4 0.1 1.2 1 0 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 CAV18036.1 - 0.022 14.5 0.3 0.048 13.4 0.3 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_16 PF13191.6 CAV18036.1 - 0.06 13.7 0.0 0.11 12.9 0.1 1.6 1 1 0 1 1 1 0 AAA ATPase domain IstB_IS21 PF01695.17 CAV18036.1 - 0.12 12.1 0.2 8.8 6.0 0.0 2.3 2 0 0 2 2 2 0 IstB-like ATP binding protein DUF87 PF01935.17 CAV18036.1 - 0.14 12.2 0.7 0.3 11.1 0.7 1.4 1 0 0 1 1 1 0 Helicase HerA, central domain TniB PF05621.11 CAV18036.1 - 0.18 11.2 0.9 1.3 8.4 0.3 2.2 2 1 0 2 2 2 0 Bacterial TniB protein ATP-synt_ab PF00006.25 CAV18036.1 - 0.21 11.2 0.0 0.33 10.6 0.0 1.4 1 0 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain AAA_22 PF13401.6 CAV18036.1 - 0.26 11.5 2.1 3.9 7.7 2.1 2.3 1 1 0 1 1 1 0 AAA domain ABC_tran PF00005.27 CAV18038.1 - 1.5e-33 116.2 0.0 2e-33 115.8 0.0 1.2 1 0 0 1 1 1 1 ABC transporter oligo_HPY PF08352.12 CAV18038.1 - 6.3e-20 71.5 0.1 1.1e-19 70.7 0.1 1.4 1 0 0 1 1 1 1 Oligopeptide/dipeptide transporter, C-terminal region SMC_N PF02463.19 CAV18038.1 - 0.00034 20.1 0.0 0.00055 19.4 0.0 1.3 1 0 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 CAV18038.1 - 0.0014 18.5 0.0 0.39 10.5 0.0 2.1 1 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system TniB PF05621.11 CAV18038.1 - 0.0019 17.6 0.2 0.019 14.4 0.0 2.2 2 0 0 2 2 2 1 Bacterial TniB protein AAA_22 PF13401.6 CAV18038.1 - 0.0025 18.1 0.1 0.016 15.5 0.1 2.1 1 1 0 1 1 1 1 AAA domain PRK PF00485.18 CAV18038.1 - 0.012 15.3 0.0 0.019 14.7 0.0 1.3 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family AAA PF00004.29 CAV18038.1 - 0.013 15.9 0.1 0.028 14.9 0.0 1.6 2 0 0 2 2 1 0 ATPase family associated with various cellular activities (AAA) AAA_13 PF13166.6 CAV18038.1 - 0.018 13.7 0.1 0.065 11.9 0.1 1.8 2 0 0 2 2 2 0 AAA domain AAA_5 PF07728.14 CAV18038.1 - 0.022 14.8 0.2 0.058 13.4 0.0 1.7 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) NACHT PF05729.12 CAV18038.1 - 0.031 14.2 0.0 0.053 13.4 0.0 1.5 1 0 0 1 1 1 0 NACHT domain RsgA_GTPase PF03193.16 CAV18038.1 - 0.042 13.7 0.0 0.081 12.8 0.0 1.5 1 0 0 1 1 1 0 RsgA GTPase AAA_29 PF13555.6 CAV18038.1 - 0.045 13.5 0.0 0.081 12.7 0.0 1.3 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_16 PF13191.6 CAV18038.1 - 0.049 14.0 0.1 0.071 13.5 0.1 1.4 1 1 0 1 1 1 0 AAA ATPase domain MMR_HSR1 PF01926.23 CAV18038.1 - 0.077 13.1 0.0 0.15 12.2 0.0 1.5 1 0 0 1 1 1 0 50S ribosome-binding GTPase RNA_helicase PF00910.22 CAV18038.1 - 0.082 13.3 0.0 0.16 12.4 0.0 1.6 1 0 0 1 1 1 0 RNA helicase NB-ARC PF00931.22 CAV18038.1 - 0.085 12.0 0.0 0.12 11.6 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain AAA_25 PF13481.6 CAV18038.1 - 0.1 12.1 0.1 2.8 7.5 0.0 2.4 2 1 0 2 2 2 0 AAA domain ATP-synt_ab PF00006.25 CAV18038.1 - 0.14 11.8 0.0 0.24 11.0 0.0 1.3 1 0 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain AAA_33 PF13671.6 CAV18038.1 - 0.15 12.3 0.1 0.58 10.3 0.1 1.8 1 1 1 2 2 2 0 AAA domain Sigma54_activat PF00158.26 CAV18038.1 - 0.16 11.6 0.2 0.43 10.3 0.0 1.7 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_30 PF13604.6 CAV18038.1 - 0.16 11.6 0.0 0.37 10.5 0.0 1.5 2 0 0 2 2 2 0 AAA domain GST_N_2 PF13409.6 CAV18040.1 - 2.1e-23 82.4 0.0 3.9e-23 81.5 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 CAV18040.1 - 2.5e-12 46.6 0.1 5.1e-12 45.6 0.1 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 CAV18040.1 - 6.8e-05 23.0 0.1 0.00011 22.4 0.1 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 CAV18040.1 - 0.00043 20.6 0.0 0.0022 18.4 0.0 2.0 1 1 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 CAV18040.1 - 0.0016 18.6 0.1 0.0029 17.8 0.1 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain YcxB PF14317.6 CAV18040.1 - 0.062 13.0 2.6 3.5 7.4 0.9 2.5 2 0 0 2 2 2 0 YcxB-like protein QIL1 PF15884.5 CAV18040.1 - 0.083 13.5 0.0 2.1 9.0 0.0 2.6 2 0 0 2 2 2 0 MICOS complex subunit MIC13, QIL1 dCache_2 PF08269.11 CAV18043.1 - 7e-74 248.7 2.7 1.3e-73 247.8 2.7 1.5 1 0 0 1 1 1 1 Cache domain EAL PF00563.20 CAV18043.1 - 1.6e-71 240.7 1.1 2e-70 237.0 0.1 2.4 2 0 0 2 2 2 1 EAL domain GGDEF PF00990.21 CAV18043.1 - 3.3e-43 147.2 0.3 8.9e-43 145.8 0.3 1.8 1 0 0 1 1 1 1 Diguanylate cyclase, GGDEF domain sCache_2 PF17200.4 CAV18043.1 - 4e-32 111.2 1.3 1.3e-25 90.0 0.0 3.5 2 1 1 3 3 3 2 Single Cache domain 2 Cache_3-Cache_2 PF17201.4 CAV18043.1 - 1.5e-15 57.3 0.0 2e-09 37.1 0.0 2.5 1 1 1 2 2 2 2 Cache 3/Cache 2 fusion domain dCache_1 PF02743.18 CAV18043.1 - 5e-05 23.2 11.2 0.00035 20.4 0.2 3.7 4 1 1 5 5 5 2 Cache domain Guanylate_cyc PF00211.20 CAV18043.1 - 0.092 12.4 0.0 0.21 11.2 0.0 1.5 1 0 0 1 1 1 0 Adenylate and Guanylate cyclase catalytic domain Alpha-mann_mid PF09261.11 CAV18043.1 - 0.16 12.2 1.5 0.38 10.9 0.0 2.3 2 1 0 2 2 2 0 Alpha mannosidase middle domain PTA_PTB PF01515.19 CAV18044.1 - 4.2e-125 417.3 2.1 6.6e-125 416.7 2.1 1.3 1 0 0 1 1 1 1 Phosphate acetyl/butaryl transferase AAA_26 PF13500.6 CAV18044.1 - 2.7e-55 187.3 0.2 6.6e-55 186.0 0.2 1.7 1 0 0 1 1 1 1 AAA domain DRTGG PF07085.12 CAV18044.1 - 2e-28 98.3 0.0 8.2e-28 96.3 0.0 2.2 2 0 0 2 2 2 1 DRTGG domain CbiA PF01656.23 CAV18044.1 - 0.029 14.4 0.2 0.66 10.0 0.2 2.9 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain LPD7 PF18821.1 CAV18044.1 - 0.034 14.3 0.0 21 5.3 0.0 3.6 4 0 0 4 4 4 0 Large polyvalent protein-associated domain 7 CW_binding_2 PF04122.12 CAV18044.1 - 0.29 11.8 2.2 1.5 9.5 0.0 3.2 3 0 0 3 3 3 0 Putative cell wall binding repeat 2 Acetate_kinase PF00871.17 CAV18045.1 - 1.9e-163 543.7 0.0 2.2e-163 543.5 0.0 1.0 1 0 0 1 1 1 1 Acetokinase family DUF412 PF04217.13 CAV18047.1 - 1.3e-58 196.9 0.6 1.5e-58 196.7 0.6 1.0 1 0 0 1 1 1 1 Protein of unknown function, DUF412 ABC_sub_bind PF04392.12 CAV18049.1 - 1.2e-98 330.0 3.1 1.4e-98 329.7 3.1 1.0 1 0 0 1 1 1 1 ABC transporter substrate binding protein GGDEF PF00990.21 CAV18050.1 - 6e-34 117.1 0.0 9.8e-34 116.4 0.0 1.4 1 0 0 1 1 1 1 Diguanylate cyclase, GGDEF domain dCache_1 PF02743.18 CAV18050.1 - 4.1e-07 30.0 0.1 1.2e-06 28.5 0.0 1.7 2 0 0 2 2 2 1 Cache domain Dus PF01207.17 CAV18052.1 - 1.1e-73 248.0 0.0 1.3e-73 247.8 0.0 1.0 1 0 0 1 1 1 1 Dihydrouridine synthase (Dus) FMN_dh PF01070.18 CAV18052.1 - 0.014 14.4 0.0 0.026 13.6 0.0 1.3 1 1 0 1 1 1 0 FMN-dependent dehydrogenase N_methyl PF07963.12 CAV18054.1 - 3.4e-07 29.6 0.3 5e-07 29.0 0.3 1.3 1 0 0 1 1 1 1 Prokaryotic N-terminal methylation motif SEC-C PF02810.15 CAV18055.1 - 4.6e-09 36.0 6.3 6.6e-09 35.5 6.3 1.2 1 0 0 1 1 1 1 SEC-C motif UPF0149 PF03695.13 CAV18055.1 - 1.3e-07 32.0 2.4 1.7e-07 31.7 2.4 1.1 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0149) DUF2433 PF10360.9 CAV18055.1 - 0.0087 16.2 0.0 0.016 15.3 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2433) DsbB PF02600.16 CAV18056.1 - 4.5e-43 147.2 14.2 5.4e-43 146.9 14.2 1.0 1 0 0 1 1 1 1 Disulfide bond formation protein DsbB NhaB PF06450.12 CAV18057.1 - 2.1e-290 963.9 31.4 2.4e-290 963.7 31.4 1.0 1 0 0 1 1 1 1 Bacterial Na+/H+ antiporter B (NhaB) CitMHS PF03600.16 CAV18057.1 - 5e-06 25.9 45.8 0.0024 17.1 2.8 3.2 2 1 1 3 3 3 3 Citrate transporter FadR_C PF07840.12 CAV18058.1 - 2.7e-65 219.2 0.8 3.4e-65 218.9 0.8 1.1 1 0 0 1 1 1 1 FadR C-terminal domain GntR PF00392.21 CAV18058.1 - 6.8e-21 73.7 0.2 1.8e-20 72.4 0.0 1.8 2 0 0 2 2 2 1 Bacterial regulatory proteins, gntR family TrmB PF01978.19 CAV18058.1 - 0.00014 21.7 0.0 0.00032 20.5 0.0 1.6 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB HTH_Crp_2 PF13545.6 CAV18058.1 - 0.00015 21.6 0.0 0.00029 20.7 0.0 1.4 1 0 0 1 1 1 1 Crp-like helix-turn-helix domain HTH_24 PF13412.6 CAV18058.1 - 0.0023 17.4 0.4 0.012 15.1 0.1 2.1 2 0 0 2 2 2 1 Winged helix-turn-helix DNA-binding Rrf2 PF02082.20 CAV18058.1 - 0.0058 16.9 0.0 0.092 13.1 0.0 2.2 2 0 0 2 2 2 1 Transcriptional regulator Fe_dep_repress PF01325.19 CAV18058.1 - 0.018 15.2 0.0 0.041 14.1 0.0 1.6 1 0 0 1 1 1 0 Iron dependent repressor, N-terminal DNA binding domain HTH_IclR PF09339.10 CAV18058.1 - 0.026 14.3 0.6 0.067 13.0 0.1 1.8 2 0 0 2 2 2 0 IclR helix-turn-helix domain PaaX PF07848.12 CAV18058.1 - 0.05 13.8 0.0 0.092 13.0 0.0 1.3 1 0 0 1 1 1 0 PaaX-like protein HTH_11 PF08279.12 CAV18058.1 - 0.081 12.9 0.1 0.88 9.6 0.1 2.4 2 0 0 2 2 2 0 HTH domain MarR PF01047.22 CAV18058.1 - 0.082 12.8 0.0 0.23 11.4 0.0 1.7 1 0 0 1 1 1 0 MarR family CortBP2 PF09727.9 CAV18058.1 - 0.093 12.6 0.0 0.16 11.8 0.0 1.3 1 0 0 1 1 1 0 Cortactin-binding protein-2 HTH_28 PF13518.6 CAV18058.1 - 0.11 12.7 0.1 0.24 11.6 0.1 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain DUF2153 PF09921.9 CAV18058.1 - 0.15 11.8 0.7 0.28 11.0 0.1 1.7 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2153) DUF1456 PF07308.13 CAV18059.1 - 3.1e-42 142.8 6.5 8.3e-21 74.1 0.5 2.0 2 0 0 2 2 2 2 Protein of unknown function (DUF1456) DUF4287 PF14117.6 CAV18059.1 - 0.03 14.4 0.0 0.051 13.7 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4287) Bromo_TP_like PF17027.5 CAV18059.1 - 0.089 12.9 0.4 0.17 12.0 0.3 1.5 1 1 0 1 1 1 0 Histone-fold protein tRNA-synt_1g PF09334.11 CAV18060.1 - 3.5e-167 556.1 0.3 4.6e-167 555.7 0.3 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (M) tRNA_bind PF01588.20 CAV18060.1 - 2.1e-26 91.9 0.0 6.9e-26 90.2 0.0 1.9 2 0 0 2 2 2 1 Putative tRNA binding domain tRNA-synt_1 PF00133.22 CAV18060.1 - 5.6e-15 54.6 0.2 1e-09 37.2 0.0 2.7 3 0 0 3 3 3 2 tRNA synthetases class I (I, L, M and V) tRNA-synt_1e PF01406.19 CAV18060.1 - 3.8e-12 46.2 0.4 7.7e-06 25.5 0.0 2.7 2 1 1 3 3 3 2 tRNA synthetases class I (C) catalytic domain tRNA-synt_1f PF01921.18 CAV18060.1 - 6.2e-07 28.7 0.0 0.00011 21.3 0.0 2.4 2 0 0 2 2 2 2 tRNA synthetases class I (K) Anticodon_1 PF08264.13 CAV18060.1 - 0.00021 21.3 0.8 0.00051 20.0 0.8 1.8 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA FeoC PF09012.10 CAV18060.1 - 0.003 17.6 0.3 0.27 11.3 0.0 3.1 3 0 0 3 3 3 1 FeoC like transcriptional regulator PhnA_Zn_Ribbon PF08274.12 CAV18060.1 - 0.11 12.4 2.1 0.3 11.1 2.1 1.7 1 0 0 1 1 1 0 PhnA Zinc-Ribbon ParA PF10609.9 CAV18061.1 - 2.3e-99 331.8 0.1 2.8e-99 331.5 0.1 1.1 1 0 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase AAA_31 PF13614.6 CAV18061.1 - 1.7e-12 47.6 0.2 1.7e-10 41.1 0.1 2.3 2 0 0 2 2 2 1 AAA domain CbiA PF01656.23 CAV18061.1 - 3e-12 46.7 0.0 4.7e-12 46.1 0.0 1.4 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain MipZ PF09140.11 CAV18061.1 - 1.9e-08 34.0 0.0 2.9e-08 33.3 0.0 1.3 1 0 0 1 1 1 1 ATPase MipZ Fer4_NifH PF00142.18 CAV18061.1 - 3.5e-06 26.7 0.1 0.00065 19.2 0.1 2.2 2 0 0 2 2 2 2 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family ArsA_ATPase PF02374.15 CAV18061.1 - 0.00011 21.6 3.2 0.0018 17.5 2.7 2.6 1 1 2 3 3 3 1 Anion-transporting ATPase VirC1 PF07015.11 CAV18061.1 - 0.00064 19.1 0.0 0.0018 17.6 0.1 1.7 2 0 0 2 2 2 1 VirC1 protein FTHFS PF01268.19 CAV18061.1 - 0.0083 14.4 0.1 0.011 13.9 0.1 1.1 1 0 0 1 1 1 1 Formate--tetrahydrofolate ligase CBP_BcsQ PF06564.12 CAV18061.1 - 0.045 13.2 0.1 0.15 11.5 0.1 1.8 2 0 0 2 2 2 0 Cellulose biosynthesis protein BcsQ MeaB PF03308.16 CAV18061.1 - 0.056 12.4 0.3 0.093 11.7 0.3 1.3 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB SRP54 PF00448.22 CAV18061.1 - 0.056 13.1 0.0 0.093 12.3 0.0 1.3 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain AAA_26 PF13500.6 CAV18061.1 - 0.064 13.1 1.0 1.5 8.6 0.9 2.3 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.6 CAV18061.1 - 0.1 12.1 0.1 0.18 11.3 0.1 1.4 1 0 0 1 1 1 0 AAA domain PRK PF00485.18 CAV18062.1 - 2.6e-41 141.5 0.0 3.1e-41 141.3 0.0 1.0 1 0 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family AAA_18 PF13238.6 CAV18062.1 - 9.2e-07 29.5 0.1 1.3e-06 28.9 0.1 1.3 1 0 0 1 1 1 1 AAA domain CoaE PF01121.20 CAV18062.1 - 0.0052 16.5 2.5 0.077 12.7 2.5 2.1 1 1 0 1 1 1 1 Dephospho-CoA kinase APS_kinase PF01583.20 CAV18062.1 - 0.006 16.5 0.1 0.48 10.3 0.0 2.3 2 0 0 2 2 2 1 Adenylylsulphate kinase NB-ARC PF00931.22 CAV18062.1 - 0.016 14.4 0.0 0.021 14.0 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain ABC_tran PF00005.27 CAV18062.1 - 0.027 15.0 0.1 0.034 14.6 0.1 1.4 1 1 0 1 1 1 0 ABC transporter AAA_16 PF13191.6 CAV18062.1 - 0.031 14.6 0.0 0.058 13.8 0.0 1.4 1 1 0 1 1 1 0 AAA ATPase domain AsmA PF05170.14 CAV18063.1 - 3.3e-115 386.2 15.2 3.8e-115 386.0 15.2 1.0 1 0 0 1 1 1 1 AsmA family AsmA_2 PF13502.6 CAV18063.1 - 1.4e-21 77.1 5.4 1.4e-21 77.1 5.4 3.3 1 1 1 3 3 3 1 AsmA-like C-terminal region CobA_CobO_BtuR PF02572.15 CAV18064.1 - 7.2e-58 195.6 4.9 8.1e-58 195.5 0.9 2.0 2 0 0 2 2 2 1 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP Co_AT_N PF12557.8 CAV18064.1 - 1.3e-07 31.3 8.4 3.3e-07 30.1 8.4 1.7 1 0 0 1 1 1 1 Cob(I)alamin adenosyltransferase N terminal Smr PF01713.21 CAV18064.1 - 0.00059 20.2 0.9 0.72 10.3 0.4 2.4 2 0 0 2 2 2 2 Smr domain AAA_22 PF13401.6 CAV18064.1 - 0.017 15.4 0.0 0.029 14.6 0.0 1.4 1 1 0 1 1 1 0 AAA domain LMWPc PF01451.21 CAV18065.1 - 1.1e-33 116.6 0.0 1.2e-33 116.5 0.0 1.0 1 0 0 1 1 1 1 Low molecular weight phosphotyrosine protein phosphatase Sulfate_transp PF00916.20 CAV18066.1 - 1.5e-57 195.1 39.3 1.6e-56 191.7 39.3 2.0 1 1 0 1 1 1 1 Sulfate permease family STAS PF01740.21 CAV18066.1 - 0.00088 18.9 0.0 0.0017 18.0 0.0 1.4 1 0 0 1 1 1 1 STAS domain STAS_2 PF13466.6 CAV18066.1 - 0.0054 17.1 0.0 0.015 15.7 0.0 1.7 1 0 0 1 1 1 1 STAS domain MFS_MOT1 PF16983.5 CAV18066.1 - 0.42 11.0 50.3 0.077 13.4 10.0 4.1 3 1 1 4 4 4 0 Molybdate transporter of MFS superfamily RNase_E_G PF10150.9 CAV18067.1 - 1e-93 313.7 0.0 1e-93 313.7 0.0 2.1 2 0 0 2 2 2 1 Ribonuclease E/G family S1 PF00575.23 CAV18067.1 - 1.2e-14 54.4 0.4 3.3e-14 53.0 0.0 2.1 2 0 0 2 2 2 1 S1 RNA binding domain PseudoU_synth_2 PF00849.22 CAV18069.1 - 1e-31 110.2 0.1 1.7e-31 109.5 0.1 1.4 1 0 0 1 1 1 1 RNA pseudouridylate synthase S4 PF01479.25 CAV18069.1 - 1.1e-10 41.1 1.0 2e-10 40.2 1.0 1.5 1 0 0 1 1 1 1 S4 domain DUF3603 PF12227.8 CAV18069.1 - 0.0011 18.3 0.1 0.0018 17.7 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3603) Orexin PF02072.15 CAV18069.1 - 0.16 11.9 0.0 0.26 11.2 0.0 1.3 1 0 0 1 1 1 0 Prepro-orexin Cupin_3 PF05899.12 CAV18069.1 - 0.18 11.5 0.0 0.46 10.2 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF861) Maf PF02545.14 CAV18070.1 - 2.4e-45 154.4 0.0 2.6e-45 154.2 0.0 1.0 1 0 0 1 1 1 1 Maf-like protein Ribonuc_red_lgN PF00317.21 CAV18070.1 - 0.13 12.2 0.0 0.2 11.7 0.0 1.3 1 0 0 1 1 1 0 Ribonucleotide reductase, all-alpha domain YceD PF02620.17 CAV18071.1 - 1.9e-18 66.7 3.1 2.6e-18 66.3 3.1 1.2 1 0 0 1 1 1 1 Large ribosomal RNA subunit accumulation protein YceD Ribosomal_L32p PF01783.23 CAV18072.1 - 4.1e-19 68.6 0.4 4.4e-19 68.5 0.4 1.0 1 0 0 1 1 1 1 Ribosomal L32p protein family FA_synthesis PF02504.15 CAV18073.1 - 1e-100 336.9 0.0 1.2e-100 336.8 0.0 1.0 1 0 0 1 1 1 1 Fatty acid synthesis protein PTA_PTB PF01515.19 CAV18073.1 - 0.00027 20.4 0.0 0.00041 19.8 0.0 1.4 1 1 0 1 1 1 1 Phosphate acetyl/butaryl transferase Phe_tRNA-synt_N PF02912.18 CAV18073.1 - 0.089 12.7 0.0 39 4.3 0.0 3.1 3 0 0 3 3 3 0 Aminoacyl tRNA synthetase class II, N-terminal domain ACP_syn_III_C PF08541.10 CAV18074.1 - 1.4e-35 121.3 0.2 1.2e-34 118.3 0.0 2.3 2 0 0 2 2 2 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal ACP_syn_III PF08545.10 CAV18074.1 - 4.3e-32 109.8 0.8 8.6e-32 108.8 0.8 1.5 1 0 0 1 1 1 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III Thiolase_N PF00108.23 CAV18074.1 - 1.3e-09 37.8 0.4 2.3e-09 37.0 0.4 1.3 1 0 0 1 1 1 1 Thiolase, N-terminal domain Chal_sti_synt_N PF00195.19 CAV18074.1 - 1.4e-05 24.6 0.4 2.5e-05 23.8 0.4 1.4 1 0 0 1 1 1 1 Chalcone and stilbene synthases, N-terminal domain FAE1_CUT1_RppA PF08392.12 CAV18074.1 - 0.003 16.9 0.1 0.0057 16.0 0.1 1.4 1 0 0 1 1 1 1 FAE1/Type III polyketide synthase-like protein SpoVAD PF07451.11 CAV18074.1 - 0.0074 15.0 0.4 0.0074 15.0 0.4 1.6 2 0 0 2 2 2 1 Stage V sporulation protein AD (SpoVAD) ketoacyl-synt PF00109.26 CAV18074.1 - 0.0078 15.8 3.1 0.039 13.5 2.4 2.2 1 1 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Acyl_transf_1 PF00698.21 CAV18076.1 - 2.2e-36 126.0 0.4 2.7e-36 125.7 0.4 1.0 1 0 0 1 1 1 1 Acyl transferase domain adh_short_C2 PF13561.6 CAV18078.1 - 1.4e-67 227.7 6.5 1.5e-67 227.5 6.5 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CAV18078.1 - 1.5e-62 210.6 4.8 1.7e-62 210.3 4.8 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CAV18078.1 - 4.1e-18 65.9 1.1 6e-18 65.4 1.1 1.2 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.6 CAV18078.1 - 0.00014 21.8 2.3 0.00018 21.4 2.3 1.2 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 CAV18078.1 - 0.00066 19.2 0.6 0.0013 18.2 0.6 1.7 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family THF_DHG_CYH_C PF02882.19 CAV18078.1 - 0.0025 17.2 1.7 0.045 13.1 0.1 2.3 2 0 0 2 2 2 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain MTS PF05175.14 CAV18078.1 - 0.1 12.1 1.0 0.42 10.2 0.1 1.9 1 1 1 2 2 2 0 Methyltransferase small domain PP-binding PF00550.25 CAV18079.1 - 2e-16 60.1 0.7 2.3e-16 59.9 0.7 1.0 1 0 0 1 1 1 1 Phosphopantetheine attachment site PP-binding_2 PF14573.6 CAV18079.1 - 3.1e-06 27.3 1.8 3.3e-06 27.2 1.8 1.2 1 0 0 1 1 1 1 Acyl-carrier DUF1896 PF08989.10 CAV18079.1 - 0.012 15.7 0.1 0.014 15.5 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1896) EutQ PF06249.12 CAV18079.1 - 0.016 15.0 0.3 0.017 14.9 0.3 1.1 1 0 0 1 1 1 0 Ethanolamine utilisation protein EutQ Ribosomal_L50 PF10501.9 CAV18079.1 - 0.048 13.8 0.1 0.066 13.4 0.1 1.4 1 1 0 1 1 1 0 Ribosomal subunit 39S Ribosomal_L12_N PF16320.5 CAV18079.1 - 0.087 12.5 1.2 0.2 11.4 0.1 2.0 2 0 0 2 2 2 0 Ribosomal protein L7/L12 dimerisation domain ketoacyl-synt PF00109.26 CAV18081.1 - 1.7e-64 217.8 1.1 1.7e-64 217.8 1.1 1.7 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.22 CAV18081.1 - 2.2e-36 124.5 1.2 4.3e-36 123.5 1.2 1.5 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain Thiolase_N PF00108.23 CAV18081.1 - 1.9e-05 24.2 0.6 5.1e-05 22.8 0.3 1.8 2 0 0 2 2 2 1 Thiolase, N-terminal domain ACP_syn_III PF08545.10 CAV18081.1 - 3.4e-05 23.6 0.3 0.41 10.5 0.0 3.1 2 0 0 2 2 2 2 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III KAsynt_C_assoc PF16197.5 CAV18081.1 - 0.0064 16.9 0.0 0.037 14.5 0.0 2.2 2 0 0 2 2 2 1 Ketoacyl-synthetase C-terminal extension Aminotran_4 PF01063.19 CAV18083.1 - 2.5e-39 135.4 0.0 3.8e-39 134.8 0.0 1.3 1 1 0 1 1 1 1 Amino-transferase class IV YceG PF02618.16 CAV18085.1 - 2.6e-82 276.5 0.0 3.1e-82 276.3 0.0 1.1 1 0 0 1 1 1 1 YceG-like family YqgF PF14639.6 CAV18085.1 - 0.1 12.4 0.0 0.27 11.0 0.0 1.7 2 0 0 2 2 2 0 Holliday-junction resolvase-like of SPT6 DUF4536 PF15055.6 CAV18085.1 - 0.11 12.7 0.3 0.35 11.2 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4536) Thymidylate_kin PF02223.17 CAV18087.1 - 1.2e-55 188.1 0.0 1.3e-55 188.0 0.0 1.0 1 0 0 1 1 1 1 Thymidylate kinase AAA_28 PF13521.6 CAV18087.1 - 4.6e-05 23.7 0.0 6e-05 23.3 0.0 1.3 1 0 0 1 1 1 1 AAA domain dNK PF01712.19 CAV18087.1 - 8.2e-05 22.6 0.1 0.0016 18.4 0.1 2.1 1 1 0 1 1 1 1 Deoxynucleoside kinase AAA_17 PF13207.6 CAV18087.1 - 0.00067 20.1 0.2 0.0026 18.2 0.2 1.9 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.6 CAV18087.1 - 0.0009 19.5 0.0 0.0015 18.8 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 CAV18087.1 - 0.0028 17.4 0.1 0.0039 16.9 0.1 1.3 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 CAV18087.1 - 0.0032 18.0 0.1 0.016 15.7 0.1 2.1 1 1 0 1 1 1 1 AAA domain MMR_HSR1 PF01926.23 CAV18087.1 - 0.0037 17.3 0.1 0.021 14.9 0.0 2.1 2 0 0 2 2 2 1 50S ribosome-binding GTPase MeaB PF03308.16 CAV18087.1 - 0.0068 15.4 0.3 0.017 14.1 0.2 1.7 1 1 1 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_33 PF13671.6 CAV18087.1 - 0.016 15.4 0.1 0.074 13.2 0.1 2.0 1 1 0 1 1 1 0 AAA domain ATPase_2 PF01637.18 CAV18087.1 - 0.027 14.4 0.0 0.036 14.0 0.0 1.3 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea ABC_tran PF00005.27 CAV18087.1 - 0.041 14.4 0.2 0.09 13.3 0.2 1.4 1 1 0 1 1 1 0 ABC transporter SbcD_C PF12320.8 CAV18087.1 - 0.059 13.7 0.3 0.33 11.3 0.1 2.0 2 0 0 2 2 2 0 Type 5 capsule protein repressor C-terminal domain RsgA_GTPase PF03193.16 CAV18087.1 - 0.074 13.0 0.2 0.13 12.1 0.1 1.6 2 0 0 2 2 2 0 RsgA GTPase AAA_16 PF13191.6 CAV18087.1 - 0.088 13.2 0.2 0.13 12.7 0.2 1.6 1 1 0 1 1 1 0 AAA ATPase domain Zeta_toxin PF06414.12 CAV18087.1 - 0.12 11.7 0.1 0.36 10.1 0.0 1.7 2 0 0 2 2 2 0 Zeta toxin AAA_29 PF13555.6 CAV18087.1 - 0.15 11.8 0.1 0.28 11.0 0.1 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain Viral_helicase1 PF01443.18 CAV18087.1 - 0.19 11.5 0.0 0.25 11.0 0.0 1.2 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase DNA_pol3_delta2 PF13177.6 CAV18089.1 - 1.1e-42 145.5 0.1 2.6e-42 144.4 0.0 1.5 2 0 0 2 2 2 1 DNA polymerase III, delta subunit DNApol3-delta_C PF09115.10 CAV18089.1 - 2.3e-21 76.5 0.4 4.6e-21 75.5 0.4 1.5 1 0 0 1 1 1 1 DNA polymerase III, delta subunit, C terminal AAA PF00004.29 CAV18089.1 - 0.0058 17.1 0.0 0.013 15.9 0.0 1.6 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) TatD_DNase PF01026.21 CAV18091.1 - 4.9e-79 265.3 0.1 5.5e-79 265.2 0.1 1.0 1 0 0 1 1 1 1 TatD related DNase PTS_EIIC PF02378.18 CAV18093.1 - 4.8e-73 246.0 31.0 4.8e-73 246.0 31.0 1.5 2 0 0 2 2 2 1 Phosphotransferase system, EIIC PTS_EIIB PF00367.20 CAV18093.1 - 4.7e-12 45.2 0.2 8e-12 44.5 0.2 1.4 1 0 0 1 1 1 1 phosphotransferase system, EIIB AA_kinase PF00696.28 CAV18093.1 - 0.043 13.4 0.1 0.11 12.0 0.1 1.7 2 0 0 2 2 2 0 Amino acid kinase family SNF PF00209.18 CAV18096.1 - 2.3e-114 383.0 41.9 1.4e-75 255.0 23.6 2.0 1 1 1 2 2 2 2 Sodium:neurotransmitter symporter family DUF4235 PF14019.6 CAV18096.1 - 0.25 11.5 0.2 0.25 11.5 0.2 3.2 4 0 0 4 4 4 0 Protein of unknown function (DUF4235) OMP_b-brl PF13505.6 CAV18098.1 - 2.6e-06 27.7 3.4 4.7e-06 26.9 3.4 1.6 1 1 0 1 1 1 1 Outer membrane protein beta-barrel domain OmpA_membrane PF01389.17 CAV18098.1 - 0.052 13.3 0.0 0.078 12.7 0.0 1.6 1 1 0 1 1 1 0 OmpA-like transmembrane domain Patatin PF01734.22 CAV18100.1 - 3.3e-14 53.6 2.0 1.5e-13 51.4 0.5 2.3 2 1 0 2 2 2 1 Patatin-like phospholipase PK PF00224.21 CAV18102.1 - 7.8e-128 426.2 10.3 1.1e-127 425.7 10.3 1.2 1 0 0 1 1 1 1 Pyruvate kinase, barrel domain PK_C PF02887.16 CAV18102.1 - 7.2e-29 100.4 1.0 3e-28 98.4 0.0 2.3 2 1 1 3 3 3 1 Pyruvate kinase, alpha/beta domain Ad_Cy_reg PF16701.5 CAV18102.1 - 0.013 15.3 3.5 0.029 14.1 3.5 1.6 1 0 0 1 1 1 0 Adenylate cyclase regulatory domain UBA_6 PF18039.1 CAV18102.1 - 0.026 14.4 0.2 0.38 10.7 0.1 2.3 2 0 0 2 2 2 0 UBA-like domain ROK PF00480.20 CAV18104.1 - 1.9e-69 234.4 0.6 2.4e-69 234.1 0.6 1.1 1 0 0 1 1 1 1 ROK family MarR PF01047.22 CAV18104.1 - 0.01 15.8 0.1 0.023 14.6 0.1 1.5 1 0 0 1 1 1 0 MarR family HTH_24 PF13412.6 CAV18104.1 - 0.032 13.8 0.1 0.059 12.9 0.1 1.5 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding CheW PF01584.19 CAV18106.1 - 1.2e-35 122.2 0.3 1.8e-35 121.6 0.3 1.2 1 0 0 1 1 1 1 CheW-like domain Response_reg PF00072.24 CAV18106.1 - 4e-14 52.7 0.7 6.1e-14 52.1 0.1 1.7 2 0 0 2 2 2 1 Response regulator receiver domain DNA_pol3_alpha PF07733.12 CAV18108.1 - 1.4e-81 274.0 0.0 2.2e-81 273.3 0.0 1.3 1 0 0 1 1 1 1 Bacterial DNA polymerase III alpha NTPase domain DNA_pol3_finger PF17657.1 CAV18108.1 - 1.5e-57 193.5 0.0 2.9e-57 192.6 0.0 1.5 1 0 0 1 1 1 1 Bacterial DNA polymerase III alpha subunit finger domain HHH_6 PF14579.6 CAV18108.1 - 1.2e-14 54.3 0.0 4.9e-14 52.4 0.0 2.1 2 0 0 2 2 2 1 Helix-hairpin-helix motif PHP PF02811.19 CAV18108.1 - 9.4e-10 39.0 0.0 2.2e-09 37.9 0.0 1.7 1 0 0 1 1 1 1 PHP domain tRNA_anti-codon PF01336.25 CAV18108.1 - 3.1e-08 33.5 0.6 6.6e-08 32.4 0.6 1.6 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA_anti_2 PF13742.6 CAV18108.1 - 0.0029 17.8 0.1 0.0076 16.4 0.1 1.7 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain T2SSK PF03934.13 CAV18108.1 - 0.11 11.9 0.0 0.26 10.6 0.0 1.6 1 0 0 1 1 1 0 Type II secretion system (T2SS), protein K IMS PF00817.20 CAV18110.1 - 8.3e-09 35.6 0.0 1.4e-08 34.9 0.0 1.3 1 0 0 1 1 1 1 impB/mucB/samB family PAS_8 PF13188.7 CAV18110.1 - 0.012 15.7 0.0 0.076 13.1 0.0 2.3 2 0 0 2 2 2 0 PAS domain DUF1805 PF08827.11 CAV18110.1 - 0.12 12.8 0.1 27 5.2 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF1805) RecA PF00154.21 CAV18112.1 - 9.6e-07 28.5 0.0 1.3e-06 28.1 0.0 1.2 1 0 0 1 1 1 1 recA bacterial DNA recombination protein MAM PF00629.23 CAV18112.1 - 0.00068 19.6 0.2 0.0034 17.3 0.2 1.8 2 0 0 2 2 2 1 MAM domain, meprin/A5/mu SulA PF03846.14 CAV18112.1 - 0.011 15.6 0.0 0.029 14.3 0.0 1.7 2 0 0 2 2 2 0 Cell division inhibitor SulA PAXNEB PF05625.11 CAV18112.1 - 0.017 14.3 0.0 0.025 13.7 0.0 1.2 1 0 0 1 1 1 0 PAXNEB protein adh_short PF00106.25 CAV18115.1 - 1.1e-51 175.1 0.0 1.3e-51 174.9 0.0 1.0 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CAV18115.1 - 1.1e-38 133.1 0.0 1.3e-38 132.9 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CAV18115.1 - 4.4e-12 46.3 0.0 6.2e-12 45.8 0.0 1.1 1 0 0 1 1 1 1 KR domain DUF1776 PF08643.10 CAV18115.1 - 0.00019 20.9 0.0 0.00028 20.4 0.0 1.2 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) Epimerase PF01370.21 CAV18115.1 - 0.0051 16.3 0.2 0.047 13.1 0.2 2.4 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3HCDH_N PF02737.18 CAV18115.1 - 0.028 14.3 0.0 0.044 13.7 0.0 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Shikimate_DH PF01488.20 CAV18115.1 - 0.14 12.3 0.0 0.29 11.2 0.0 1.5 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Peptidase_S49_N PF08496.10 CAV18116.1 - 8.6e-56 188.2 5.1 4.2e-55 186.0 3.9 2.1 2 0 0 2 2 2 1 Peptidase family S49 N-terminal Peptidase_S49 PF01343.18 CAV18116.1 - 2.5e-47 160.7 0.0 4.3e-47 159.9 0.0 1.4 1 0 0 1 1 1 1 Peptidase family S49 SDH_sah PF01972.16 CAV18116.1 - 0.012 14.7 0.0 0.02 13.9 0.0 1.4 1 0 0 1 1 1 0 Serine dehydrogenase proteinase SpoVR PF04293.13 CAV18118.1 - 1.1e-175 584.4 9.8 1.3e-175 584.1 9.8 1.0 1 0 0 1 1 1 1 SpoVR like protein DUF639 PF04842.12 CAV18118.1 - 0.18 11.2 0.0 0.31 10.4 0.0 1.3 1 0 0 1 1 1 0 Plant protein of unknown function (DUF639) DUF444 PF04285.12 CAV18120.1 - 1.8e-187 623.6 2.3 2.1e-187 623.4 2.3 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF444) AAA_PrkA PF08298.11 CAV18122.1 - 2.8e-172 572.6 0.0 4.2e-172 572.0 0.0 1.3 1 0 0 1 1 1 1 PrkA AAA domain PrkA PF06798.12 CAV18122.1 - 4.9e-71 239.4 2.7 8.8e-71 238.5 2.7 1.4 1 0 0 1 1 1 1 PrkA serine protein kinase C-terminal domain AAA_16 PF13191.6 CAV18122.1 - 0.00014 22.3 0.0 0.00046 20.6 0.0 1.9 1 0 0 1 1 1 1 AAA ATPase domain AAA_5 PF07728.14 CAV18122.1 - 0.012 15.6 0.1 0.13 12.2 0.1 2.3 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) Sigma54_activat PF00158.26 CAV18122.1 - 0.022 14.5 0.0 2.8 7.6 0.0 2.3 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_22 PF13401.6 CAV18122.1 - 0.028 14.7 0.0 0.13 12.5 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_33 PF13671.6 CAV18122.1 - 0.087 13.0 0.0 0.2 11.8 0.0 1.6 1 0 0 1 1 1 0 AAA domain Med31 PF05669.12 CAV18122.1 - 1.9 8.5 5.1 2.7 8.1 0.2 2.9 1 1 0 2 2 2 0 SOH1 MipA PF06629.12 CAV18124.1 - 3.5e-42 145.1 1.9 4e-42 144.9 1.9 1.0 1 0 0 1 1 1 1 MltA-interacting protein MipA Autotransporter PF03797.19 CAV18124.1 - 0.00033 20.4 3.3 0.0057 16.3 0.1 2.9 2 1 1 3 3 3 1 Autotransporter beta-domain OMP_b-brl PF13505.6 CAV18124.1 - 0.0016 18.6 4.3 0.0097 16.1 4.3 2.0 1 1 0 1 1 1 1 Outer membrane protein beta-barrel domain Pom PF17251.2 CAV18124.1 - 0.085 12.2 0.2 0.24 10.7 0.1 1.7 2 0 0 2 2 2 0 Protochlamydia outer membrane protein YfbU PF03887.14 CAV18126.1 - 3.2e-69 232.2 7.5 3.5e-69 232.1 7.5 1.0 1 0 0 1 1 1 1 YfbU domain NHR2 PF08788.11 CAV18126.1 - 0.036 13.8 0.0 0.1 12.3 0.0 1.8 1 0 0 1 1 1 0 NHR2 domain like FumaraseC_C PF10415.9 CAV18126.1 - 0.089 13.2 0.0 0.19 12.2 0.0 1.6 1 0 0 1 1 1 0 Fumarase C C-terminus DUF3106 PF11304.8 CAV18126.1 - 0.42 11.1 4.6 4.3 7.9 0.1 2.7 2 1 1 3 3 3 0 Protein of unknown function (DUF3106) Radical_SAM PF04055.21 CAV18128.1 - 7.8e-31 107.7 0.4 1.3e-30 107.0 0.4 1.3 1 0 0 1 1 1 1 Radical SAM superfamily Fer4_12 PF13353.6 CAV18128.1 - 7.6e-20 71.6 0.0 1.1e-19 71.1 0.0 1.3 1 0 0 1 1 1 1 4Fe-4S single cluster domain Fer4_14 PF13394.6 CAV18128.1 - 1.9e-06 28.0 0.1 3.9e-06 27.0 0.1 1.5 2 0 0 2 2 2 1 4Fe-4S single cluster domain DUF2219 PF09982.9 CAV18130.1 - 3.3e-82 276.0 6.0 3.8e-82 275.8 6.0 1.0 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2219) PFL-like PF02901.15 CAV18132.1 - 7.4e-202 672.5 0.1 1e-201 672.0 0.1 1.1 1 0 0 1 1 1 1 Pyruvate formate lyase-like Gly_radical PF01228.21 CAV18132.1 - 8e-44 148.5 0.0 1.8e-43 147.4 0.0 1.6 1 0 0 1 1 1 1 Glycine radical DUF2680 PF10925.8 CAV18132.1 - 0.13 12.2 0.5 0.44 10.6 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2680) Histone_HNS PF00816.21 CAV18132.1 - 0.23 12.3 0.4 0.52 11.2 0.4 1.5 1 0 0 1 1 1 0 H-NS histone family DUF3360 PF11840.8 CAV18134.1 - 5.7e-265 879.5 18.1 6.7e-265 879.3 18.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3360) Xan_ur_permease PF00860.20 CAV18134.1 - 0.41 9.3 30.5 0.0096 14.7 15.1 2.5 2 1 0 2 2 2 0 Permease family DUF2834 PF11196.8 CAV18134.1 - 0.7 10.3 7.3 0.1 13.0 1.2 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF2834) DUF1129 PF06570.11 CAV18134.1 - 4.1 6.8 11.1 0.16 11.4 0.2 2.9 2 1 1 3 3 3 0 Protein of unknown function (DUF1129) ABC_tran PF00005.27 CAV18136.1 - 2.5e-32 112.2 0.0 3.4e-32 111.8 0.0 1.2 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 CAV18136.1 - 2.7e-13 50.4 0.0 4.3e-07 30.0 0.0 2.1 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 CAV18136.1 - 1.7e-06 27.6 0.2 0.00011 21.7 0.2 2.3 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 CAV18136.1 - 0.00026 20.7 0.1 0.00044 19.9 0.1 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_13 PF13166.6 CAV18136.1 - 0.001 17.8 0.0 0.12 11.0 0.0 2.0 1 1 0 2 2 2 2 AAA domain AAA_25 PF13481.6 CAV18136.1 - 0.0011 18.6 0.0 0.002 17.7 0.0 1.4 1 0 0 1 1 1 1 AAA domain ABC_ATPase PF09818.9 CAV18136.1 - 0.0059 15.4 0.2 2.6 6.8 0.0 2.5 3 0 0 3 3 3 2 Predicted ATPase of the ABC class AAA_23 PF13476.6 CAV18136.1 - 0.0078 16.7 0.1 0.014 15.9 0.1 1.4 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 CAV18136.1 - 0.017 15.5 0.1 0.028 14.8 0.1 1.6 1 1 0 1 1 1 0 AAA ATPase domain G-alpha PF00503.20 CAV18136.1 - 0.017 14.3 0.0 0.019 14.2 0.0 1.2 1 0 0 1 1 1 0 G-protein alpha subunit RsgA_GTPase PF03193.16 CAV18136.1 - 0.031 14.2 0.0 0.053 13.4 0.0 1.5 1 0 0 1 1 1 0 RsgA GTPase Mg_chelatase PF01078.21 CAV18136.1 - 0.038 13.4 0.0 0.07 12.5 0.0 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI PRK PF00485.18 CAV18136.1 - 0.046 13.4 0.1 0.21 11.3 0.0 1.9 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family AAA_33 PF13671.6 CAV18136.1 - 0.064 13.4 0.0 0.13 12.4 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_15 PF13175.6 CAV18136.1 - 0.065 12.9 0.0 0.16 11.6 0.0 1.6 2 0 0 2 2 2 0 AAA ATPase domain AAA_19 PF13245.6 CAV18136.1 - 0.092 13.1 0.0 0.15 12.4 0.0 1.5 1 1 0 1 1 1 0 AAA domain Rad17 PF03215.15 CAV18136.1 - 0.1 12.5 0.0 0.14 12.0 0.0 1.2 1 0 0 1 1 1 0 Rad17 P-loop domain PhoH PF02562.16 CAV18136.1 - 0.12 11.8 0.0 0.22 11.0 0.0 1.3 1 0 0 1 1 1 0 PhoH-like protein NACHT PF05729.12 CAV18136.1 - 0.16 11.9 0.0 0.33 10.9 0.0 1.5 1 0 0 1 1 1 0 NACHT domain SBP_bac_3 PF00497.20 CAV18138.1 - 2.7e-61 206.9 0.2 3.1e-61 206.7 0.2 1.0 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 Lig_chan-Glu_bd PF10613.9 CAV18138.1 - 2.1e-09 37.6 0.0 1.9e-08 34.5 0.0 2.1 1 1 0 1 1 1 1 Ligated ion channel L-glutamate- and glycine-binding site BPD_transp_1 PF00528.22 CAV18140.1 - 3.6e-20 72.5 15.9 5e-20 72.0 15.9 1.3 1 0 0 1 1 1 1 Binding-protein-dependent transport system inner membrane component DUF4227 PF14004.6 CAV18140.1 - 0.12 12.3 1.5 9.2 6.3 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF4227) BPD_transp_1 PF00528.22 CAV18142.1 - 6.2e-19 68.4 12.4 6.2e-19 68.4 12.4 1.7 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component IMPa_helical PF18642.1 CAV18144.1 - 6.6e-38 129.5 3.4 6.6e-38 129.5 3.4 2.3 2 0 0 2 2 2 1 Immunomodulating metalloprotease helical domain M60-like_N PF17291.2 CAV18144.1 - 0.00013 21.8 0.1 0.00057 19.7 0.1 2.0 2 1 0 2 2 2 1 N-terminal domain of M60-like peptidases Peptidase_M60 PF13402.6 CAV18144.1 - 0.34 10.4 4.2 0.74 9.3 4.2 1.7 1 1 0 1 1 1 0 Peptidase M60, enhancin and enhancin-like Exo_endo_phos PF03372.23 CAV18146.1 - 1.7e-21 76.8 0.0 2e-21 76.6 0.0 1.1 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.6 CAV18146.1 - 0.029 14.2 0.1 1.8 8.5 0.0 2.4 2 0 0 2 2 2 0 Endonuclease-reverse transcriptase FTSW_RODA_SPOVE PF01098.19 CAV18146.1 - 0.12 11.3 0.0 0.17 10.9 0.0 1.1 1 0 0 1 1 1 0 Cell cycle protein Peptidase_S9_N PF02897.15 CAV18148.1 - 3.4e-98 329.1 12.1 4.6e-98 328.7 12.1 1.1 1 0 0 1 1 1 1 Prolyl oligopeptidase, N-terminal beta-propeller domain Peptidase_S9 PF00326.21 CAV18148.1 - 1.1e-68 230.9 0.1 2e-68 230.0 0.1 1.5 1 0 0 1 1 1 1 Prolyl oligopeptidase family Esterase PF00756.20 CAV18148.1 - 0.02 14.6 0.0 0.042 13.5 0.0 1.5 1 0 0 1 1 1 0 Putative esterase MFS_1 PF07690.16 CAV18150.1 - 1.3e-43 149.3 41.2 1.3e-43 149.3 41.2 1.4 2 0 0 2 2 2 1 Major Facilitator Superfamily MFS_2 PF13347.6 CAV18150.1 - 5e-10 38.5 21.8 3.4e-05 22.6 12.6 2.4 1 1 1 2 2 2 2 MFS/sugar transport protein Sugar_tr PF00083.24 CAV18150.1 - 1.1e-08 34.4 4.2 1.1e-08 34.4 4.2 3.2 1 1 2 3 3 3 2 Sugar (and other) transporter TRI12 PF06609.13 CAV18150.1 - 1.4e-05 23.7 2.5 1.4e-05 23.7 2.5 2.0 1 1 1 2 2 2 1 Fungal trichothecene efflux pump (TRI12) DUF2530 PF10745.9 CAV18150.1 - 0.12 12.6 0.2 0.12 12.6 0.2 4.4 4 1 1 5 5 5 0 Protein of unknown function (DUF2530) MCPsignal PF00015.21 CAV18151.1 - 1.4e-42 145.5 23.0 1.4e-42 145.5 23.0 4.4 2 1 1 4 4 4 1 Methyl-accepting chemotaxis protein (MCP) signalling domain dCache_1 PF02743.18 CAV18151.1 - 1.6e-16 60.9 1.0 1.6e-16 60.9 1.0 2.7 3 1 0 3 3 3 1 Cache domain HAMP PF00672.25 CAV18151.1 - 6.5e-16 58.5 0.4 3.5e-15 56.1 0.0 2.6 3 0 0 3 3 3 1 HAMP domain DUF4064 PF13273.6 CAV18151.1 - 0.44 10.9 6.2 6.5 7.1 0.2 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF4064) Sorting_nexin PF03700.13 CAV18151.1 - 2.3 8.8 5.7 1.1 9.8 2.5 2.1 2 0 0 2 2 2 0 Sorting nexin, N-terminal domain DUF948 PF06103.11 CAV18151.1 - 4.1 7.7 29.4 2.4 8.5 1.1 5.6 4 2 1 5 5 5 0 Bacterial protein of unknown function (DUF948) Cupin_4 PF08007.12 CAV18153.1 - 2.5e-88 296.6 0.0 2.8e-88 296.4 0.0 1.0 1 0 0 1 1 1 1 Cupin superfamily protein Cupin_8 PF13621.6 CAV18153.1 - 0.016 14.9 0.0 0.063 13.0 0.0 2.1 1 1 0 2 2 2 0 Cupin-like domain Cupin_2 PF07883.11 CAV18153.1 - 0.026 14.2 0.2 0.29 10.9 0.0 2.7 3 0 0 3 3 3 0 Cupin domain Cupin_1 PF00190.22 CAV18153.1 - 0.082 12.5 0.0 0.18 11.4 0.0 1.5 1 0 0 1 1 1 0 Cupin DUF2496 PF10689.9 CAV18155.1 - 8.5e-24 83.1 4.1 9.8e-24 82.9 4.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2496) PriC PF07445.12 CAV18157.1 - 3.7e-41 140.9 8.9 4.2e-41 140.8 8.9 1.0 1 0 0 1 1 1 1 Primosomal replication protein priC Ribosomal_L36e PF01158.18 CAV18157.1 - 0.025 14.8 0.7 0.058 13.6 0.7 1.8 1 1 0 1 1 1 0 Ribosomal protein L36e Sec20 PF03908.13 CAV18157.1 - 0.052 13.5 0.6 0.18 11.7 0.2 2.1 2 0 0 2 2 2 0 Sec20 DUF2481 PF10654.9 CAV18157.1 - 0.062 13.3 0.7 0.23 11.4 0.2 2.1 2 1 2 4 4 4 0 Protein of unknown function (DUF2481) FUSC PF04632.12 CAV18157.1 - 0.2 10.1 1.4 0.18 10.3 1.4 1.0 1 0 0 1 1 1 0 Fusaric acid resistance protein family XhlA PF10779.9 CAV18157.1 - 1.8 8.8 5.4 13 6.0 0.7 2.7 2 1 0 2 2 2 0 Haemolysin XhlA TauE PF01925.19 CAV18159.1 - 8.5e-45 153.2 22.8 1e-44 152.9 22.8 1.0 1 0 0 1 1 1 1 Sulfite exporter TauE/SafE Helicase_C_2 PF13307.6 CAV18161.1 - 4e-36 124.8 0.0 8.8e-36 123.6 0.0 1.6 1 0 0 1 1 1 1 Helicase C-terminal domain DEAD_2 PF06733.15 CAV18161.1 - 1.6e-06 27.8 0.0 3.8e-06 26.6 0.0 1.7 1 1 0 1 1 1 1 DEAD_2 ResIII PF04851.15 CAV18161.1 - 2.3e-05 24.5 0.0 7.4e-05 22.8 0.0 1.8 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.29 CAV18161.1 - 0.00027 20.7 0.1 0.002 17.9 0.0 2.3 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CAV18161.1 - 0.0013 19.0 0.0 0.0036 17.6 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain PTPA PF03095.15 CAV18161.1 - 0.06 12.8 0.1 0.11 12.0 0.1 1.3 1 0 0 1 1 1 0 Phosphotyrosyl phosphate activator (PTPA) protein Porin_4 PF13609.6 CAV18163.1 - 5.3e-27 95.4 28.5 7.1e-27 95.0 28.5 1.0 1 0 0 1 1 1 1 Gram-negative porin PepSY_2 PF13670.6 CAV18163.1 - 0.03 14.3 0.4 2.2 8.3 0.0 2.8 2 0 0 2 2 2 0 Peptidase propeptide and YPEB domain DUF4148 PF13663.6 CAV18163.1 - 0.034 14.3 0.0 0.083 13.1 0.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4148) Sugarporin_N PF11471.8 CAV18163.1 - 0.18 11.8 0.5 0.37 10.8 0.5 1.5 1 0 0 1 1 1 0 Maltoporin periplasmic N-terminal extension PseudoU_synth_2 PF00849.22 CAV18165.1 - 1.7e-16 60.8 0.0 4.2e-16 59.4 0.0 1.7 2 0 0 2 2 2 1 RNA pseudouridylate synthase IDH PF03971.14 CAV18169.1 - 0 1300.5 0.5 0 1300.4 0.5 1.0 1 0 0 1 1 1 1 Monomeric isocitrate dehydrogenase CSD PF00313.22 CAV18171.1 - 7.9e-28 96.1 0.0 8.9e-28 95.9 0.0 1.0 1 0 0 1 1 1 1 'Cold-shock' DNA-binding domain OB_RNB PF08206.11 CAV18171.1 - 0.0026 17.4 0.1 0.0034 17.0 0.1 1.3 1 0 0 1 1 1 1 Ribonuclease B OB domain ClpS PF02617.17 CAV18173.1 - 8.2e-34 115.3 0.1 9.7e-34 115.0 0.1 1.1 1 0 0 1 1 1 1 ATP-dependent Clp protease adaptor protein ClpS AAA_2 PF07724.14 CAV18175.1 - 2.6e-50 170.9 0.2 4e-47 160.5 0.0 2.9 2 1 0 2 2 2 2 AAA domain (Cdc48 subfamily) AAA_lid_9 PF17871.1 CAV18175.1 - 3.4e-29 100.8 4.7 4.5e-29 100.4 2.6 2.3 2 0 0 2 2 2 1 AAA lid domain ClpB_D2-small PF10431.9 CAV18175.1 - 4.6e-24 84.3 0.0 1.2e-23 82.9 0.0 1.8 1 0 0 1 1 1 1 C-terminal, D2-small domain, of ClpB protein AAA PF00004.29 CAV18175.1 - 1.3e-22 80.6 0.0 7.1e-12 45.9 0.0 3.2 2 1 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 CAV18175.1 - 1.2e-15 57.7 0.1 4.3e-10 39.7 0.0 2.6 2 0 0 2 2 2 2 AAA domain (dynein-related subfamily) Clp_N PF02861.20 CAV18175.1 - 3.1e-14 52.8 2.9 1.3e-13 50.8 1.8 2.5 2 0 0 2 2 2 1 Clp amino terminal domain, pathogenicity island component Sigma54_activat PF00158.26 CAV18175.1 - 7.9e-09 35.4 0.1 0.0011 18.7 0.0 2.7 2 0 0 2 2 2 2 Sigma-54 interaction domain AAA_16 PF13191.6 CAV18175.1 - 2.5e-07 31.2 9.3 4.4e-05 23.9 0.1 4.2 4 1 0 5 5 5 1 AAA ATPase domain TniB PF05621.11 CAV18175.1 - 3.7e-07 29.7 0.0 0.00016 21.1 0.0 3.1 2 1 0 2 2 2 1 Bacterial TniB protein AAA_22 PF13401.6 CAV18175.1 - 1.1e-05 25.7 5.5 0.19 12.0 0.1 4.9 3 2 0 3 3 3 2 AAA domain AAA_18 PF13238.6 CAV18175.1 - 2.9e-05 24.6 0.3 0.041 14.4 0.0 3.4 3 0 0 3 3 3 1 AAA domain AAA_14 PF13173.6 CAV18175.1 - 3.7e-05 23.8 0.0 0.015 15.3 0.0 2.9 2 0 0 2 2 2 1 AAA domain AAA_7 PF12775.7 CAV18175.1 - 6.2e-05 22.6 0.0 0.094 12.2 0.0 2.7 2 1 0 2 2 2 2 P-loop containing dynein motor region Mg_chelatase PF01078.21 CAV18175.1 - 6.7e-05 22.4 0.2 0.95 8.8 0.0 3.8 2 2 2 4 4 4 1 Magnesium chelatase, subunit ChlI ResIII PF04851.15 CAV18175.1 - 0.00011 22.3 0.1 1.8 8.6 0.0 3.5 2 1 1 3 3 3 1 Type III restriction enzyme, res subunit RuvB_N PF05496.12 CAV18175.1 - 0.00013 21.8 3.3 1.4 8.7 0.8 4.1 3 1 0 3 3 3 2 Holliday junction DNA helicase RuvB P-loop domain TIP49 PF06068.13 CAV18175.1 - 0.00031 20.1 0.0 0.076 12.2 0.0 2.6 2 0 0 2 2 2 1 TIP49 P-loop domain IstB_IS21 PF01695.17 CAV18175.1 - 0.00072 19.3 0.1 0.15 11.8 0.0 2.5 2 0 0 2 2 2 1 IstB-like ATP binding protein AAA_3 PF07726.11 CAV18175.1 - 0.00082 19.2 0.2 0.037 13.9 0.1 3.0 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_25 PF13481.6 CAV18175.1 - 0.0016 18.0 0.3 0.68 9.5 0.0 3.0 3 0 0 3 3 2 1 AAA domain AAA_6 PF12774.7 CAV18175.1 - 0.0081 15.2 0.0 0.042 12.8 0.0 2.1 3 0 0 3 3 3 1 Hydrolytic ATP binding site of dynein motor region RNA_helicase PF00910.22 CAV18175.1 - 0.012 15.9 0.2 11 6.4 0.0 3.3 4 0 0 4 4 3 0 RNA helicase TsaE PF02367.17 CAV18175.1 - 0.015 15.3 0.0 4.7 7.2 0.0 2.4 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE PhoH PF02562.16 CAV18175.1 - 0.037 13.5 0.6 1.2 8.5 0.0 3.1 3 0 0 3 3 3 0 PhoH-like protein NACHT PF05729.12 CAV18175.1 - 0.045 13.7 0.1 0.2 11.6 0.0 2.0 2 0 0 2 2 2 0 NACHT domain RsgA_GTPase PF03193.16 CAV18175.1 - 0.064 13.2 0.6 6.5 6.6 0.0 2.9 3 0 0 3 3 2 0 RsgA GTPase AAA_29 PF13555.6 CAV18175.1 - 0.071 12.9 0.0 14 5.5 0.0 2.5 2 0 0 2 2 2 0 P-loop containing region of AAA domain DNA_pol3_delta2 PF13177.6 CAV18175.1 - 0.14 11.9 0.1 18 5.0 0.0 3.8 5 0 0 5 5 5 0 DNA polymerase III, delta subunit AAA_33 PF13671.6 CAV18175.1 - 0.15 12.3 0.0 13 5.9 0.0 2.8 2 0 0 2 2 2 0 AAA domain ATPase_2 PF01637.18 CAV18175.1 - 0.24 11.3 1.2 23 4.8 0.0 3.1 2 1 1 3 3 3 0 ATPase domain predominantly from Archaea AAA_23 PF13476.6 CAV18175.1 - 5 7.6 7.5 15 6.0 0.5 3.6 2 1 0 3 3 3 0 AAA domain eIF-1a PF01176.19 CAV18177.1 - 1.4e-27 95.2 0.1 1.6e-27 95.1 0.1 1.0 1 0 0 1 1 1 1 Translation initiation factor 1A / IF-1 RsgA_N PF16745.5 CAV18177.1 - 6.8e-05 22.5 0.0 8.2e-05 22.3 0.0 1.3 1 0 0 1 1 1 1 RsgA N-terminal domain S1 PF00575.23 CAV18177.1 - 0.057 13.8 0.1 0.067 13.5 0.1 1.2 1 0 0 1 1 1 0 S1 RNA binding domain Myosin_N PF02736.19 CAV18177.1 - 0.094 12.6 0.0 5.2 7.0 0.0 2.3 2 0 0 2 2 2 0 Myosin N-terminal SH3-like domain RNase_II_C_S1 PF18614.1 CAV18177.1 - 0.11 12.5 0.0 0.28 11.1 0.0 1.9 1 1 0 1 1 1 0 RNase II-type exonuclease C-terminal S1 domain ATE_C PF04377.15 CAV18179.1 - 6.9e-32 110.9 0.7 1e-31 110.3 0.7 1.3 1 0 0 1 1 1 1 Arginine-tRNA-protein transferase, C terminus ATE_N PF04376.13 CAV18179.1 - 5e-18 65.3 0.1 1.3e-17 63.9 0.1 1.7 1 0 0 1 1 1 1 Arginine-tRNA-protein transferase, N terminus PPO1_DWL PF12142.8 CAV18179.1 - 0.035 13.9 0.7 0.31 10.9 0.0 2.7 2 1 1 3 3 3 0 Polyphenol oxidase middle domain Leu_Phe_trans PF03588.14 CAV18181.1 - 1.8e-67 226.1 0.0 2.2e-67 225.8 0.0 1.1 1 0 0 1 1 1 1 Leucyl/phenylalanyl-tRNA protein transferase Acetyltransf_6 PF13480.7 CAV18181.1 - 0.03 14.5 0.0 0.052 13.7 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Rick_17kDa_Anti PF05433.15 CAV18183.1 - 1.1e-08 34.8 14.7 1.4e-08 34.4 14.7 1.2 1 0 0 1 1 1 1 Glycine zipper 2TM domain Gly-zipper_Omp PF13488.6 CAV18183.1 - 0.00018 21.4 28.7 0.0022 17.9 16.4 1.8 1 1 1 2 2 2 2 Glycine zipper Gly-zipper_YMGG PF13441.6 CAV18183.1 - 0.00021 20.9 14.0 0.00034 20.3 14.0 1.3 1 0 0 1 1 1 1 YMGG-like Gly-zipper Transgly_assoc PF04226.13 CAV18183.1 - 2.1 8.7 9.7 3.3 8.0 9.7 1.3 1 0 0 1 1 1 0 Transglycosylase associated protein EPSP_synthase PF00275.20 CAV18185.1 - 3.1e-156 520.3 0.0 3.5e-156 520.1 0.0 1.0 1 0 0 1 1 1 1 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) Orthopox_F14 PF06076.12 CAV18185.1 - 0.0052 17.0 0.0 0.17 12.2 0.0 2.8 2 0 0 2 2 2 1 Orthopoxvirus F14 protein Yqai PF09466.10 CAV18185.1 - 0.0073 16.6 0.1 0.83 10.0 0.0 2.5 2 0 0 2 2 2 1 Hypothetical protein Yqai YscJ_FliF PF01514.17 CAV18185.1 - 0.16 11.6 0.0 0.32 10.6 0.0 1.4 1 0 0 1 1 1 0 Secretory protein of YscJ/FliF family DUF2498 PF10692.9 CAV18187.1 - 6.1e-41 138.2 0.6 6.7e-41 138.0 0.6 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2498) RasGAP_C PF03836.15 CAV18187.1 - 0.077 13.1 0.0 0.11 12.7 0.0 1.1 1 0 0 1 1 1 0 RasGAP C-terminus Topoisom_bac PF01131.20 CAV18188.1 - 1.2e-126 423.0 0.5 1.7e-126 422.6 0.5 1.2 1 0 0 1 1 1 1 DNA topoisomerase Topo_Zn_Ribbon PF08272.11 CAV18188.1 - 3.4e-33 113.0 0.0 2.9e-19 68.5 0.4 2.7 2 0 0 2 2 2 2 Topoisomerase I zinc-ribbon-like Toprim PF01751.22 CAV18188.1 - 4.6e-33 113.5 0.1 9.9e-33 112.4 0.1 1.6 1 0 0 1 1 1 1 Toprim domain zf-C4_Topoisom PF01396.19 CAV18188.1 - 3.8e-15 55.4 20.3 7.9e-09 35.2 2.4 4.5 4 1 0 4 4 4 3 Topoisomerase DNA binding C4 zinc finger Toprim_2 PF13155.6 CAV18188.1 - 0.018 15.5 0.1 0.18 12.2 0.1 2.7 1 1 0 1 1 1 0 Toprim-like Toprim_4 PF13662.6 CAV18188.1 - 0.084 13.4 0.2 0.59 10.6 0.1 2.7 3 1 0 3 3 3 0 Toprim domain Zn_Tnp_IS1 PF03811.13 CAV18188.1 - 0.49 10.2 2.7 3.9 7.3 0.0 3.1 3 0 0 3 3 3 0 InsA N-terminal domain NTP_transferase PF00483.23 CAV18190.1 - 1.3e-63 214.9 0.0 1.6e-63 214.6 0.0 1.1 1 0 0 1 1 1 1 Nucleotidyl transferase NTP_transf_3 PF12804.7 CAV18190.1 - 5.3e-07 30.1 0.0 7.6e-07 29.6 0.0 1.3 1 0 0 1 1 1 1 MobA-like NTP transferase domain Hexapep PF00132.24 CAV18190.1 - 0.019 14.7 0.3 0.69 9.7 0.1 2.8 1 1 1 2 2 2 0 Bacterial transferase hexapeptide (six repeats) Fucokinase PF07959.12 CAV18190.1 - 0.047 12.6 0.0 0.3 10.0 0.1 1.9 2 0 0 2 2 2 0 L-fucokinase Glyco_transf_5 PF08323.11 CAV18193.1 - 1.5e-68 231.2 0.7 4.1e-68 229.7 0.3 1.9 2 0 0 2 2 2 1 Starch synthase catalytic domain Glycos_transf_1 PF00534.20 CAV18193.1 - 2.8e-15 56.3 0.0 5.3e-15 55.4 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 CAV18193.1 - 1.8e-12 47.9 0.0 3.8e-12 46.8 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.6 CAV18193.1 - 0.0009 19.7 0.0 0.0018 18.7 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferase 4-like domain Glyco_transf_4 PF13439.6 CAV18193.1 - 0.001 19.1 0.0 0.0019 18.2 0.0 1.6 1 1 0 1 1 1 1 Glycosyltransferase Family 4 Abhydrolase_1 PF00561.20 CAV18195.1 - 3.5e-23 82.6 0.0 2.9e-21 76.3 0.1 2.1 2 0 0 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CAV18195.1 - 4.3e-17 63.5 0.0 5.2e-17 63.2 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CAV18195.1 - 1.5e-12 47.3 0.0 1.9e-12 47.0 0.0 1.1 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Ndr PF03096.14 CAV18195.1 - 3.1e-05 22.8 0.2 6.9e-05 21.7 0.2 1.5 1 1 0 1 1 1 1 Ndr family FSH1 PF03959.13 CAV18195.1 - 0.0038 16.9 0.0 0.056 13.1 0.0 2.3 2 0 0 2 2 2 1 Serine hydrolase (FSH1) Palm_thioest PF02089.15 CAV18195.1 - 0.015 15.1 0.0 0.021 14.7 0.0 1.4 1 0 0 1 1 1 0 Palmitoyl protein thioesterase DUF2007 PF09413.10 CAV18197.1 - 1.4e-09 37.9 0.0 1.8e-09 37.6 0.0 1.1 1 0 0 1 1 1 1 Putative prokaryotic signal transducing protein Cytochrom_c3_2 PF14537.6 CAV18197.1 - 0.023 15.1 0.3 0.034 14.6 0.3 1.2 1 0 0 1 1 1 0 Cytochrome c3 Nup54_57_C PF18570.1 CAV18197.1 - 0.13 11.9 0.2 0.2 11.3 0.2 1.3 1 0 0 1 1 1 0 NUP57/Nup54 C-terminal domain SNARE_assoc PF09335.11 CAV18198.1 - 1.2e-21 77.5 6.9 1.2e-21 77.5 6.9 2.3 1 1 1 2 2 2 1 SNARE associated Golgi protein UPF0182 PF03699.13 CAV18198.1 - 0.046 11.9 12.2 0.066 11.3 12.2 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0182) TfoX_C PF04994.13 CAV18200.1 - 1.8e-31 108.0 0.1 2.6e-31 107.5 0.1 1.2 1 0 0 1 1 1 1 TfoX C-terminal domain TfoX_N PF04993.13 CAV18200.1 - 2.4e-30 104.6 0.0 3.6e-30 104.0 0.0 1.3 1 0 0 1 1 1 1 TfoX N-terminal domain Peripla_BP_3 PF13377.6 CAV18202.1 - 6.2e-43 147.0 0.0 1.5e-42 145.7 0.0 1.6 2 0 0 2 2 2 1 Periplasmic binding protein-like domain Peripla_BP_1 PF00532.21 CAV18202.1 - 4.3e-29 101.8 0.0 5.7e-29 101.4 0.0 1.1 1 0 0 1 1 1 1 Periplasmic binding proteins and sugar binding domain of LacI family LacI PF00356.21 CAV18202.1 - 6.8e-21 73.8 1.2 1.3e-20 72.9 1.2 1.5 1 0 0 1 1 1 1 Bacterial regulatory proteins, lacI family Peripla_BP_4 PF13407.6 CAV18202.1 - 1.6e-19 70.5 0.0 2.5e-19 69.9 0.0 1.3 1 0 0 1 1 1 1 Periplasmic binding protein domain HTH_Tnp_ISL3 PF13542.6 CAV18202.1 - 0.0043 16.4 1.3 0.0071 15.7 0.3 1.9 2 0 0 2 2 2 1 Helix-turn-helix domain of transposase family ISL3 HTH_3 PF01381.22 CAV18202.1 - 0.0082 16.2 0.0 0.022 14.8 0.0 1.8 1 0 0 1 1 1 1 Helix-turn-helix HTH_38 PF13936.6 CAV18202.1 - 0.045 13.5 0.0 0.78 9.6 0.1 2.6 2 0 0 2 2 2 0 Helix-turn-helix domain MerR PF00376.23 CAV18202.1 - 0.11 12.3 0.2 0.25 11.2 0.2 1.6 1 0 0 1 1 1 0 MerR family regulatory protein HTH_23 PF13384.6 CAV18202.1 - 0.12 12.2 0.1 0.49 10.3 0.1 2.0 1 1 1 2 2 2 0 Homeodomain-like domain HTH_31 PF13560.6 CAV18202.1 - 0.16 12.4 0.0 0.28 11.6 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain Nitrate_red_del PF02613.15 CAV18204.1 - 3.9e-37 127.3 0.4 7.3e-37 126.4 0.4 1.3 1 0 0 1 1 1 1 Nitrate reductase delta subunit NLRC4_HD2 PF17776.1 CAV18204.1 - 0.028 15.0 0.4 0.46 11.0 0.0 2.3 2 1 0 2 2 2 0 NLRC4 helical domain HD2 Response_reg PF00072.24 CAV18208.1 - 2.9e-28 98.3 0.2 7.6e-28 96.9 0.2 1.7 2 0 0 2 2 2 1 Response regulator receiver domain Trans_reg_C PF00486.28 CAV18208.1 - 6.8e-21 74.1 0.0 4.7e-20 71.4 0.0 2.2 2 1 0 2 2 2 1 Transcriptional regulatory protein, C terminal DNA_meth_N PF18284.1 CAV18208.1 - 0.065 13.1 0.0 0.14 12.1 0.0 1.6 1 0 0 1 1 1 0 DNA methylase N-terminal domain DUF218 PF02698.17 CAV18210.1 - 1.4e-26 93.1 0.0 1.8e-26 92.7 0.0 1.1 1 0 0 1 1 1 1 DUF218 domain Dak1_2 PF13684.6 CAV18210.1 - 0.073 12.1 0.0 0.094 11.8 0.0 1.1 1 0 0 1 1 1 0 Dihydroxyacetone kinase family Pox_P21 PF05313.12 CAV18210.1 - 0.12 12.0 0.6 0.2 11.2 0.6 1.3 1 0 0 1 1 1 0 Poxvirus P21 membrane protein DUF1516 PF07457.11 CAV18210.1 - 0.25 11.6 2.0 0.33 11.2 0.6 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1516) Methyltransf_11 PF08241.12 CAV18212.1 - 3.4e-13 50.1 0.0 5.6e-13 49.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CAV18212.1 - 2e-11 44.5 0.0 3.5e-11 43.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CAV18212.1 - 1.1e-10 41.6 0.0 1.5e-10 41.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CAV18212.1 - 1.1e-09 38.3 0.0 1.8e-09 37.6 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CAV18212.1 - 4.4e-09 37.0 0.0 7.9e-09 36.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 CAV18212.1 - 1.7e-07 30.8 0.0 2.6e-07 30.2 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family rRNA_methylase PF06962.12 CAV18212.1 - 0.0019 18.2 0.1 0.018 15.0 0.1 2.1 1 1 0 1 1 1 1 Putative rRNA methylase Methyltransf_24 PF13578.6 CAV18212.1 - 0.013 16.6 0.0 0.025 15.6 0.0 1.5 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_3 PF01596.17 CAV18212.1 - 0.033 13.4 0.0 0.068 12.3 0.0 1.4 1 1 1 2 2 2 0 O-methyltransferase TehB PF03848.14 CAV18212.1 - 0.034 13.6 0.0 0.05 13.0 0.0 1.2 1 0 0 1 1 1 0 Tellurite resistance protein TehB MukF_M PF17192.4 CAV18214.1 - 7.4e-79 263.1 5.6 1.3e-78 262.2 5.6 1.4 1 0 0 1 1 1 1 MukF middle domain MukF_C PF17193.4 CAV18214.1 - 5.8e-76 254.0 1.3 5.8e-76 254.0 1.3 2.0 2 0 0 2 2 2 1 MukF C-terminal domain KicB PF03882.14 CAV18214.1 - 8.2e-54 180.7 0.0 2.2e-53 179.3 0.0 1.8 1 0 0 1 1 1 1 MukF winged-helix domain Sec2p PF06428.11 CAV18214.1 - 0.063 13.3 2.3 0.17 11.9 2.3 1.7 1 0 0 1 1 1 0 GDP/GTP exchange factor Sec2p DUF1931 PF09123.11 CAV18214.1 - 0.14 12.3 0.8 30 4.7 0.2 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF1931) Yos1 PF08571.10 CAV18214.1 - 0.21 11.9 0.2 5.1 7.4 0.0 2.4 2 0 0 2 2 2 0 Yos1-like DUF16 PF01519.16 CAV18214.1 - 0.31 11.5 5.5 2.7 8.5 3.7 3.1 3 1 0 3 3 3 0 Protein of unknown function DUF16 TBCA PF02970.16 CAV18214.1 - 0.31 11.4 2.6 0.79 10.1 2.6 1.7 1 0 0 1 1 1 0 Tubulin binding cofactor A WXG100 PF06013.12 CAV18214.1 - 1.5 9.1 6.0 2.8 8.2 4.4 2.3 2 0 0 2 2 2 0 Proteins of 100 residues with WXG NPV_P10 PF05531.12 CAV18214.1 - 1.8 9.1 4.9 76 3.9 4.9 2.8 1 1 0 1 1 1 0 Nucleopolyhedrovirus P10 protein MukE PF04288.13 CAV18215.1 - 4.1e-116 385.8 0.7 4.9e-116 385.6 0.7 1.0 1 0 0 1 1 1 1 MukE-like family MukB PF04310.12 CAV18217.1 - 7.1e-121 402.2 3.2 1.8e-120 400.9 0.0 3.2 3 0 0 3 3 3 1 MukB N-terminal MukB_hinge PF16330.5 CAV18217.1 - 3.6e-71 238.2 0.3 3.6e-71 238.2 0.3 4.8 5 1 0 5 5 5 1 MukB hinge domain SbcCD_C PF13558.6 CAV18217.1 - 5.5e-15 55.4 0.7 1.7e-14 53.8 0.0 2.3 2 0 0 2 2 2 1 Putative exonuclease SbcCD, C subunit AAA_29 PF13555.6 CAV18217.1 - 2.6e-09 36.7 0.2 5.6e-09 35.6 0.2 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_23 PF13476.6 CAV18217.1 - 0.00028 21.4 0.0 0.00028 21.4 0.0 8.3 4 2 0 5 5 5 1 AAA domain SMC_N PF02463.19 CAV18217.1 - 0.0097 15.4 6.4 7.9 5.8 0.0 4.1 3 1 0 3 3 3 2 RecF/RecN/SMC N terminal domain ABC_tran PF00005.27 CAV18217.1 - 0.015 15.8 0.1 0.015 15.8 0.1 5.8 5 2 0 5 5 5 0 ABC transporter DUF1192 PF06698.11 CAV18217.1 - 2 8.6 11.5 3.1 7.9 0.4 4.7 3 0 0 3 3 3 0 Protein of unknown function (DUF1192) EF-hand_14 PF17959.1 CAV18217.1 - 2.6 8.5 5.5 15 6.0 0.0 4.8 4 1 0 4 4 4 0 EF-hand domain MCPsignal PF00015.21 CAV18219.1 - 6.5e-42 143.3 48.2 1e-41 142.6 26.2 3.3 2 1 2 4 4 4 2 Methyl-accepting chemotaxis protein (MCP) signalling domain dCache_1 PF02743.18 CAV18219.1 - 5.4e-17 62.4 0.9 5.4e-17 62.4 0.9 3.8 3 2 0 3 3 3 1 Cache domain FUSC PF04632.12 CAV18219.1 - 0.75 8.3 10.2 1.3 7.5 10.2 1.3 1 0 0 1 1 1 0 Fusaric acid resistance protein family TMPIT PF07851.13 CAV18219.1 - 1.2 8.3 18.2 2.2 7.5 4.2 2.7 2 0 0 2 2 2 0 TMPIT-like protein ATPgrasp_ST PF14397.6 CAV18221.1 - 6.7e-114 380.0 0.0 7.6e-114 379.8 0.0 1.0 1 0 0 1 1 1 1 Sugar-transfer associated ATP-grasp ATPgrasp_YheCD PF14398.6 CAV18221.1 - 5.6e-10 38.9 0.0 2.4e-05 23.7 0.0 2.5 2 1 0 2 2 2 2 YheC/D like ATP-grasp RimK PF08443.11 CAV18221.1 - 1.2e-09 38.1 0.3 0.0047 16.5 0.4 3.0 2 1 0 2 2 2 2 RimK-like ATP-grasp domain ATP-grasp_3 PF02655.14 CAV18221.1 - 1.8e-07 31.4 0.0 0.02 14.9 0.0 2.3 2 0 0 2 2 2 2 ATP-grasp domain GSH-S_ATP PF02955.16 CAV18221.1 - 2.4e-07 30.3 0.1 0.015 14.7 0.1 2.3 2 0 0 2 2 2 2 Prokaryotic glutathione synthetase, ATP-grasp domain ATPgrasp_TupA PF14305.6 CAV18221.1 - 2.1e-05 24.4 0.0 2.8e-05 24.0 0.0 1.2 1 0 0 1 1 1 1 TupA-like ATPgrasp TTL PF03133.15 CAV18221.1 - 0.065 12.4 0.0 1.8 7.6 0.0 2.1 2 0 0 2 2 2 0 Tubulin-tyrosine ligase family Dala_Dala_lig_C PF07478.13 CAV18221.1 - 0.075 12.6 0.0 0.32 10.5 0.0 1.8 2 0 0 2 2 2 0 D-ala D-ala ligase C-terminus 7TM_transglut PF14402.6 CAV18223.1 - 3.8e-109 364.0 22.7 5.4e-109 363.5 22.7 1.2 1 0 0 1 1 1 1 7 transmembrane helices usually fused to an inactive transglutaminase Transglut_i_TM PF14400.6 CAV18223.1 - 1.2e-56 191.2 0.0 1.9e-56 190.6 0.0 1.3 1 0 0 1 1 1 1 Inactive transglutaminase fused to 7 transmembrane helices Zn_protease PF05618.11 CAV18225.1 - 3.3e-48 163.1 1.2 4.8e-48 162.5 1.2 1.2 1 0 0 1 1 1 1 Putative ATP-dependant zinc protease gag-asp_proteas PF13975.6 CAV18225.1 - 0.0018 18.8 0.1 0.044 14.3 0.1 2.5 1 1 0 1 1 1 1 gag-polyprotein putative aspartyl protease SlyX PF04102.12 CAV18225.1 - 0.0029 18.2 0.4 0.0068 17.0 0.4 1.7 1 0 0 1 1 1 1 SlyX SKA1 PF07160.12 CAV18225.1 - 0.0087 15.9 2.5 0.01 15.7 2.0 1.4 1 1 0 1 1 1 1 Spindle and kinetochore-associated protein 1 DUF489 PF04356.12 CAV18225.1 - 0.013 15.5 0.3 0.023 14.7 0.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF489) BRE1 PF08647.11 CAV18225.1 - 0.03 14.4 0.6 0.03 14.4 0.6 1.9 2 0 0 2 2 2 0 BRE1 E3 ubiquitin ligase CENP-Q PF13094.6 CAV18225.1 - 0.058 13.6 0.9 0.11 12.7 0.9 1.4 1 0 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit Noelin-1 PF12308.8 CAV18225.1 - 0.086 12.8 0.9 0.15 12.0 0.9 1.4 1 0 0 1 1 1 0 Neurogenesis glycoprotein Lzipper-MIP1 PF14389.6 CAV18225.1 - 0.11 12.8 2.4 0.23 11.8 2.0 1.7 2 0 0 2 2 2 0 Leucine-zipper of ternary complex factor MIP1 Methyltransf_9 PF08003.11 CAV18227.1 - 1.7e-169 562.7 0.1 1.9e-169 562.6 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) Methyltransf_23 PF13489.6 CAV18227.1 - 6.1e-14 52.2 0.0 1e-13 51.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CAV18227.1 - 1.7e-08 34.4 0.0 5.8e-08 32.7 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CAV18227.1 - 4e-07 30.7 0.0 9.9e-07 29.4 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 CAV18227.1 - 1.5e-06 28.9 0.0 2.9e-06 28.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CAV18227.1 - 1.2e-05 25.8 0.0 3.4e-05 24.4 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain CMAS PF02353.20 CAV18227.1 - 0.0018 17.6 0.0 0.0027 17.1 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase PCMT PF01135.19 CAV18227.1 - 0.11 12.3 0.1 0.3 10.8 0.1 1.7 1 1 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) MTS PF05175.14 CAV18227.1 - 0.17 11.4 0.0 0.38 10.3 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_25 PF13649.6 CAV18228.1 - 3.3e-13 50.2 0.0 8e-13 48.9 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 CAV18228.1 - 1.8e-12 47.8 0.0 4.5e-12 46.5 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 CAV18228.1 - 3.1e-09 36.8 0.0 8.9e-09 35.3 0.0 1.6 1 1 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 CAV18228.1 - 1.1e-08 35.7 0.0 1.9e-08 34.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_2 PF00891.18 CAV18228.1 - 1.2e-06 28.0 0.0 1.6e-06 27.6 0.0 1.2 1 0 0 1 1 1 1 O-methyltransferase domain Methyltransf_23 PF13489.6 CAV18228.1 - 3.2e-06 27.1 0.0 4.2e-06 26.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 CAV18228.1 - 1.7e-05 24.3 0.0 3.1e-05 23.4 0.0 1.4 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family CheR PF01739.18 CAV18228.1 - 2e-05 24.2 0.0 0.074 12.5 0.0 2.2 1 1 1 2 2 2 2 CheR methyltransferase, SAM binding domain MTS PF05175.14 CAV18228.1 - 0.00081 19.0 0.0 0.0011 18.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain DREV PF05219.12 CAV18228.1 - 0.0015 17.7 0.0 0.0021 17.2 0.0 1.2 1 0 0 1 1 1 1 DREV methyltransferase Methyltransf_8 PF05148.15 CAV18228.1 - 0.003 17.5 0.8 0.065 13.1 0.1 2.6 2 1 1 3 3 3 1 Hypothetical methyltransferase Rsm22 PF09243.10 CAV18228.1 - 0.0031 16.8 0.0 0.0046 16.3 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial small ribosomal subunit Rsm22 PCMT PF01135.19 CAV18228.1 - 0.0049 16.6 0.0 0.0082 15.9 0.0 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) UPF0020 PF01170.18 CAV18228.1 - 0.02 14.5 0.0 0.032 13.9 0.0 1.3 1 0 0 1 1 1 0 Putative RNA methylase family UPF0020 Methyltransf_24 PF13578.6 CAV18228.1 - 0.026 15.5 0.0 0.11 13.5 0.0 1.9 2 0 0 2 2 2 0 Methyltransferase domain MetW PF07021.12 CAV18228.1 - 0.049 13.2 0.0 0.076 12.6 0.0 1.3 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW PrmA PF06325.13 CAV18228.1 - 0.049 13.0 0.0 0.072 12.5 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_18 PF12847.7 CAV18228.1 - 0.065 13.2 0.1 0.11 12.4 0.1 1.3 1 0 0 1 1 1 0 Methyltransferase domain PRMT5 PF05185.16 CAV18228.1 - 0.1 12.5 0.0 0.16 11.8 0.0 1.2 1 0 0 1 1 1 0 PRMT5 arginine-N-methyltransferase DUF72 PF01904.18 CAV18229.1 - 6.3e-55 186.6 0.2 7.6e-55 186.4 0.2 1.1 1 0 0 1 1 1 1 Protein of unknown function DUF72 tRNA-synt_2 PF00152.20 CAV18230.1 - 1.8e-103 345.9 0.0 2.6e-103 345.4 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) GAD PF02938.14 CAV18230.1 - 2.2e-29 101.5 0.1 4.8e-29 100.4 0.1 1.6 1 0 0 1 1 1 1 GAD domain tRNA_anti-codon PF01336.25 CAV18230.1 - 1.3e-15 57.1 0.1 3e-15 56.0 0.1 1.6 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.20 CAV18230.1 - 0.00015 21.4 0.1 0.19 11.2 0.0 2.4 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) tRNA-synt_2b PF00587.25 CAV18230.1 - 0.12 12.4 0.0 0.49 10.3 0.0 1.9 2 0 0 2 2 2 0 tRNA synthetase class II core domain (G, H, P, S and T) RuvC PF02075.17 CAV18231.1 - 1.2e-60 203.6 0.1 1.5e-60 203.4 0.1 1.0 1 0 0 1 1 1 1 Crossover junction endodeoxyribonuclease RuvC DUF3882 PF07066.11 CAV18231.1 - 0.0034 17.5 0.0 0.005 16.9 0.0 1.3 1 0 0 1 1 1 1 Lactococcus phage M3 protein MCR_beta_N PF02783.15 CAV18231.1 - 0.014 15.0 0.3 0.025 14.2 0.2 1.4 1 1 0 1 1 1 0 Methyl-coenzyme M reductase beta subunit, N-terminal domain MCPsignal PF00015.21 CAV18232.1 - 1.2e-32 113.1 20.8 1.2e-32 113.1 20.8 3.1 1 1 2 3 3 3 2 Methyl-accepting chemotaxis protein (MCP) signalling domain DUF1664 PF07889.12 CAV18232.1 - 0.0044 17.1 20.6 0.058 13.4 3.6 3.8 2 2 2 4 4 4 3 Protein of unknown function (DUF1664) Gp-FAR-1 PF05823.12 CAV18232.1 - 0.14 12.5 4.3 0.32 11.4 0.7 2.9 1 1 1 2 2 2 0 Nematode fatty acid retinoid binding protein (Gp-FAR-1) DUF2987 PF11205.8 CAV18232.1 - 0.22 11.4 4.6 0.65 9.9 4.6 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2987) CENP-F_leu_zip PF10473.9 CAV18232.1 - 0.22 11.5 20.2 1.3 9.0 2.4 2.5 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF812 PF05667.11 CAV18232.1 - 1.6 7.5 25.3 0.35 9.7 17.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF812) DUF1430 PF07242.11 CAV18232.1 - 2 8.7 8.5 1.7 9.0 1.5 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1430) Laminin_II PF06009.12 CAV18232.1 - 2.8 8.0 22.8 2.9 7.9 4.5 3.3 2 2 1 3 3 3 0 Laminin Domain II RuvA_N PF01330.21 CAV18233.1 - 6.7e-23 80.6 0.5 2.7e-22 78.6 0.1 2.1 2 1 0 2 2 2 1 RuvA N terminal domain RuvA_C PF07499.13 CAV18233.1 - 1e-17 64.3 0.7 2.2e-17 63.2 0.7 1.6 1 0 0 1 1 1 1 RuvA, C-terminal domain HHH_5 PF14520.6 CAV18233.1 - 6.6e-16 58.7 0.7 2.7e-14 53.5 0.1 2.6 3 0 0 3 3 3 1 Helix-hairpin-helix domain HHH PF00633.23 CAV18233.1 - 3.6e-05 23.4 4.8 0.00021 21.0 0.1 3.3 3 0 0 3 3 3 1 Helix-hairpin-helix motif IMS_HHH PF11798.8 CAV18233.1 - 0.0099 16.2 0.4 0.072 13.4 0.0 2.3 2 0 0 2 2 2 1 IMS family HHH motif DUF3173 PF11372.8 CAV18233.1 - 0.012 15.4 0.0 0.95 9.4 0.0 3.0 2 1 1 3 3 3 0 Domain of unknown function (DUF3173) PG_binding_2 PF08823.11 CAV18233.1 - 0.016 15.5 0.1 0.045 14.1 0.0 1.8 2 0 0 2 2 2 0 Putative peptidoglycan binding domain HHH_8 PF14716.6 CAV18233.1 - 0.11 12.9 0.4 0.49 10.8 0.0 2.3 3 0 0 3 3 3 0 Helix-hairpin-helix domain PaRep2b PF07775.11 CAV18233.1 - 0.14 10.6 0.0 0.18 10.2 0.0 1.1 1 0 0 1 1 1 0 PaRep2b protein Cdd1 PF11731.8 CAV18233.1 - 0.15 12.3 0.0 1.2 9.4 0.0 2.2 2 0 0 2 2 2 0 Pathogenicity locus RuvB_N PF05496.12 CAV18234.1 - 2.7e-82 274.2 0.1 3.5e-82 273.8 0.1 1.2 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_lid_4 PF17864.1 CAV18234.1 - 4.9e-33 112.7 0.1 1.1e-32 111.6 0.1 1.6 1 0 0 1 1 1 1 RuvB AAA lid domain RuvB_C PF05491.13 CAV18234.1 - 8.3e-26 89.7 0.0 1.5e-25 88.8 0.0 1.5 1 0 0 1 1 1 1 RuvB C-terminal winged helix domain AAA PF00004.29 CAV18234.1 - 8.8e-20 71.5 0.0 1.5e-19 70.7 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 CAV18234.1 - 3.7e-09 36.7 0.0 7.2e-05 22.8 0.0 2.3 1 1 1 2 2 2 2 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.21 CAV18234.1 - 3.1e-05 23.5 0.2 0.028 13.8 0.0 2.6 3 0 0 3 3 3 2 Magnesium chelatase, subunit ChlI AAA_22 PF13401.6 CAV18234.1 - 4.8e-05 23.7 0.1 0.011 16.1 0.0 2.4 1 1 1 2 2 2 1 AAA domain AAA_3 PF07726.11 CAV18234.1 - 0.00013 21.8 0.0 0.086 12.7 0.0 2.3 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 CAV18234.1 - 0.00024 20.9 0.0 0.39 10.4 0.0 2.2 1 1 1 2 2 2 2 Sigma-54 interaction domain AAA_14 PF13173.6 CAV18234.1 - 0.0011 19.0 0.0 0.0023 18.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 CAV18234.1 - 0.0016 18.8 0.1 0.12 12.7 0.0 2.5 1 1 1 2 2 2 1 AAA ATPase domain Rad17 PF03215.15 CAV18234.1 - 0.0018 18.3 0.0 0.0027 17.6 0.0 1.3 1 0 0 1 1 1 1 Rad17 P-loop domain NTPase_1 PF03266.15 CAV18234.1 - 0.002 18.1 0.2 0.1 12.5 0.0 2.5 1 1 1 2 2 2 1 NTPase TIP49 PF06068.13 CAV18234.1 - 0.0069 15.6 0.4 0.052 12.7 0.0 2.2 2 0 0 2 2 2 1 TIP49 P-loop domain Bac_DnaA PF00308.18 CAV18234.1 - 0.0074 16.1 0.0 0.25 11.2 0.0 2.3 2 0 0 2 2 2 1 Bacterial dnaA protein DUF815 PF05673.13 CAV18234.1 - 0.011 14.9 0.0 1.2 8.2 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF815) AAA_18 PF13238.6 CAV18234.1 - 0.017 15.6 0.0 0.05 14.1 0.0 1.9 1 1 0 1 1 1 0 AAA domain NB-ARC PF00931.22 CAV18234.1 - 0.019 14.1 0.0 0.038 13.2 0.0 1.4 1 0 0 1 1 1 0 NB-ARC domain MCM PF00493.23 CAV18234.1 - 0.027 13.6 0.0 1.2 8.1 0.0 2.4 1 1 0 1 1 1 0 MCM P-loop domain RNA_helicase PF00910.22 CAV18234.1 - 0.03 14.7 0.0 0.061 13.7 0.0 1.6 1 0 0 1 1 1 0 RNA helicase TniB PF05621.11 CAV18234.1 - 0.037 13.5 0.1 0.58 9.5 0.0 2.2 1 1 1 2 2 2 0 Bacterial TniB protein T2SSE PF00437.20 CAV18234.1 - 0.038 13.0 0.0 0.063 12.3 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein IstB_IS21 PF01695.17 CAV18234.1 - 0.039 13.7 0.1 0.22 11.2 0.1 2.1 1 1 0 1 1 1 0 IstB-like ATP binding protein ABC_tran PF00005.27 CAV18234.1 - 0.048 14.2 0.0 0.082 13.4 0.0 1.4 1 0 0 1 1 1 0 ABC transporter AAA_24 PF13479.6 CAV18234.1 - 0.049 13.4 0.1 0.14 11.8 0.1 1.7 1 1 0 1 1 1 0 AAA domain AAA_2 PF07724.14 CAV18234.1 - 0.054 13.6 0.1 0.79 9.8 0.1 2.2 1 1 0 1 1 1 0 AAA domain (Cdc48 subfamily) AAA_19 PF13245.6 CAV18234.1 - 0.058 13.7 0.5 1.6 9.0 0.0 2.3 1 1 1 2 2 2 0 AAA domain RsgA_GTPase PF03193.16 CAV18234.1 - 0.069 13.1 0.0 0.12 12.3 0.0 1.3 1 0 0 1 1 1 0 RsgA GTPase Sigma54_activ_2 PF14532.6 CAV18234.1 - 0.07 13.3 0.0 0.12 12.5 0.0 1.3 1 0 0 1 1 1 0 Sigma-54 interaction domain ResIII PF04851.15 CAV18234.1 - 0.11 12.5 0.1 3.8 7.5 0.0 2.1 1 1 1 2 2 2 0 Type III restriction enzyme, res subunit TsaE PF02367.17 CAV18234.1 - 0.12 12.4 0.0 0.21 11.6 0.0 1.3 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_17 PF13207.6 CAV18234.1 - 0.12 12.8 0.0 0.26 11.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_PrkA PF08298.11 CAV18234.1 - 0.12 11.2 0.0 0.19 10.6 0.0 1.3 1 0 0 1 1 1 0 PrkA AAA domain MMR_HSR1 PF01926.23 CAV18234.1 - 0.18 11.9 0.0 1.7 8.8 0.0 2.2 2 0 0 2 2 2 0 50S ribosome-binding GTPase Cyt_bd_oxida_I PF01654.17 CAV18235.1 - 1.6e-178 593.6 22.4 1.9e-178 593.4 22.4 1.1 1 0 0 1 1 1 1 Cytochrome bd terminal oxidase subunit I Cyt_bd_oxida_II PF02322.15 CAV18236.1 - 4.9e-105 351.2 30.9 5.8e-105 351.0 30.9 1.0 1 0 0 1 1 1 1 Cytochrome bd terminal oxidase subunit II 7tm_7 PF08395.12 CAV18236.1 - 0.1 11.8 3.7 0.12 11.6 0.2 2.2 2 0 0 2 2 2 0 7tm Chemosensory receptor DUF5080 PF16883.5 CAV18236.1 - 2.3 8.3 5.6 1.2 9.2 0.2 2.8 2 1 2 4 4 4 0 Domain of unknown function (DUF5080) DUF2755 PF10954.8 CAV18236.1 - 3 7.8 8.0 24 4.9 0.2 3.8 4 1 0 4 4 4 0 Protein of unknown function (DUF2755) TrbC PF04956.13 CAV18236.1 - 8.2 6.7 11.1 17 5.7 0.3 3.7 3 1 1 4 4 4 0 TrbC/VIRB2 family Cyd_oper_YbgE PF09600.10 CAV18237.1 - 2e-29 101.8 8.4 2.3e-29 101.6 8.4 1.1 1 0 0 1 1 1 1 Cyd operon protein YbgE (Cyd_oper_YbgE) MadM PF03818.13 CAV18237.1 - 0.02 14.8 0.0 0.038 13.8 0.0 1.5 1 0 0 1 1 1 0 Malonate/sodium symporter MadM subunit 4HBT PF03061.22 CAV18239.1 - 3.3e-18 65.8 0.0 4.1e-18 65.5 0.0 1.1 1 0 0 1 1 1 1 Thioesterase superfamily 4HBT_2 PF13279.6 CAV18239.1 - 3.4e-15 56.6 0.1 3.9e-15 56.4 0.1 1.0 1 0 0 1 1 1 1 Thioesterase-like superfamily Acyl-ACP_TE PF01643.17 CAV18239.1 - 9.7e-06 25.0 0.0 1.2e-05 24.7 0.0 1.0 1 0 0 1 1 1 1 Acyl-ACP thioesterase MotA_ExbB PF01618.16 CAV18240.1 - 1.5e-41 141.1 0.5 2.1e-41 140.6 0.5 1.2 1 0 0 1 1 1 1 MotA/TolQ/ExbB proton channel family SIT PF15330.6 CAV18240.1 - 0.031 14.7 0.0 0.059 13.8 0.0 1.5 1 1 0 1 1 1 0 SHP2-interacting transmembrane adaptor protein, SIT ExbD PF02472.16 CAV18241.1 - 7.8e-25 87.5 0.1 9e-25 87.3 0.1 1.0 1 0 0 1 1 1 1 Biopolymer transport protein ExbD/TolR TolA PF06519.11 CAV18242.1 - 2e-28 98.4 0.0 2e-28 98.4 0.0 2.2 2 0 0 2 2 2 1 TolA C-terminal AF-4 PF05110.13 CAV18242.1 - 7.1 4.6 42.3 9.3 4.2 42.3 1.0 1 0 0 1 1 1 0 AF-4 proto-oncoprotein PD40 PF07676.12 CAV18243.1 - 1.3e-39 133.4 2.5 8.3e-14 51.1 0.4 6.3 6 0 0 6 6 6 4 WD40-like Beta Propeller Repeat TolB_N PF04052.13 CAV18243.1 - 7.8e-35 119.3 0.0 1.6e-34 118.3 0.0 1.5 1 0 0 1 1 1 1 TolB amino-terminal domain DPPIV_N PF00930.21 CAV18243.1 - 5.4e-10 38.6 0.0 0.0011 17.8 0.0 2.7 1 1 1 2 2 2 2 Dipeptidyl peptidase IV (DPP IV) N-terminal region Pectate_lyase22 PF14583.6 CAV18243.1 - 8.2e-10 37.9 0.1 0.071 11.8 0.0 3.6 1 1 2 3 3 3 3 Oligogalacturonate lyase Lactonase PF10282.9 CAV18243.1 - 1.1e-05 24.9 0.1 0.12 11.6 0.1 2.3 1 1 1 2 2 2 2 Lactonase, 7-bladed beta-propeller SGL PF08450.12 CAV18243.1 - 9.3e-05 22.1 0.0 0.033 13.8 0.0 2.5 1 1 0 2 2 2 2 SMP-30/Gluconolactonase/LRE-like region Gmad1 PF10647.9 CAV18243.1 - 0.0077 16.0 0.0 12 5.6 0.0 3.4 2 1 2 4 4 4 2 Lipoprotein LpqB beta-propeller domain Peptidase_S9_N PF02897.15 CAV18243.1 - 0.094 11.5 0.0 1.2 7.9 0.0 1.9 1 1 0 2 2 2 0 Prolyl oligopeptidase, N-terminal beta-propeller domain OmpA PF00691.20 CAV18244.1 - 1e-21 77.1 0.5 1.6e-21 76.5 0.0 1.5 2 0 0 2 2 2 1 OmpA family Pilus_CpaD PF09476.10 CAV18244.1 - 0.31 10.7 3.4 1.9 8.1 0.1 2.1 1 1 1 2 2 2 0 Pilus biogenesis CpaD protein (pilus_cpaD) DUF3558 PF12079.8 CAV18244.1 - 3.4 7.6 8.6 4.2 7.3 8.6 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF3558) TolA_bind_tri PF16331.5 CAV18245.1 - 1.7e-23 82.5 11.0 3.3e-23 81.5 11.0 1.5 1 0 0 1 1 1 1 TolA binding protein trimerisation TPR_6 PF13174.6 CAV18245.1 - 3.7e-15 55.4 5.4 3e-06 27.5 0.0 3.8 4 0 0 4 4 3 3 Tetratricopeptide repeat TPR_16 PF13432.6 CAV18245.1 - 2.6e-11 44.0 0.0 5.4e-07 30.2 0.0 2.5 1 1 0 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.17 CAV18245.1 - 3.7e-11 42.2 0.1 0.007 16.4 0.0 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 CAV18245.1 - 1e-09 37.8 0.9 0.0066 16.6 0.0 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.6 CAV18245.1 - 1.9e-08 34.7 0.0 0.00067 20.1 0.0 2.5 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.28 CAV18245.1 - 1.6e-07 30.8 1.1 0.12 12.3 0.0 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.6 CAV18245.1 - 8e-07 29.4 0.0 0.3 12.0 0.0 3.7 3 0 0 3 3 3 2 Tetratricopeptide repeat YfiO PF13525.6 CAV18245.1 - 1.6e-05 24.7 5.1 0.0003 20.6 5.1 2.1 1 1 0 1 1 1 1 Outer membrane lipoprotein TPR_12 PF13424.6 CAV18245.1 - 0.00038 20.7 0.2 0.0086 16.3 0.0 2.5 1 1 1 2 2 2 2 Tetratricopeptide repeat ATG16 PF08614.11 CAV18245.1 - 0.00073 19.8 4.2 0.00073 19.8 4.2 1.5 2 0 0 2 2 2 1 Autophagy protein 16 (ATG16) DUF4795 PF16043.5 CAV18245.1 - 0.0034 17.0 0.9 0.0055 16.3 0.9 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4795) TPR_21 PF09976.9 CAV18245.1 - 0.0069 16.1 5.0 0.24 11.1 0.3 2.2 1 1 0 1 1 1 1 Tetratricopeptide repeat-like domain Spc29 PF17082.5 CAV18245.1 - 0.011 15.7 5.7 0.012 15.5 5.4 1.4 1 1 0 1 1 1 0 Spindle Pole Component 29 ANAPC3 PF12895.7 CAV18245.1 - 0.014 15.6 0.8 0.21 11.8 0.1 2.4 1 1 1 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_17 PF13431.6 CAV18245.1 - 0.016 15.5 0.5 1.7 9.2 0.0 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_18 PF13512.6 CAV18245.1 - 0.017 15.2 4.7 1.8 8.6 0.8 2.5 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_7 PF13176.6 CAV18245.1 - 0.033 14.2 1.4 4.8 7.4 0.0 3.6 4 0 0 4 4 3 0 Tetratricopeptide repeat Acyl-CoA_dh_2 PF08028.11 CAV18245.1 - 0.053 13.8 0.7 0.16 12.2 0.1 2.0 2 1 0 2 2 2 0 Acyl-CoA dehydrogenase, C-terminal domain YabA PF06156.13 CAV18245.1 - 0.068 13.8 0.3 0.16 12.6 0.3 1.6 1 0 0 1 1 1 0 Initiation control protein YabA DUF2730 PF10805.8 CAV18245.1 - 0.12 12.5 1.3 0.25 11.5 0.5 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2730) Orthopox_A36R PF05950.11 CAV18245.1 - 0.12 12.5 2.8 1.8 8.7 1.3 2.3 2 0 0 2 2 2 0 Orthopoxvirus A36R protein DUF4810 PF16068.5 CAV18245.1 - 0.29 11.7 3.9 8 7.1 0.1 3.6 3 1 0 4 4 3 0 Domain of unknown function (DUF4810) RPN6_N PF18055.1 CAV18245.1 - 3.4 8.0 6.9 0.5 10.7 1.9 2.1 2 1 0 2 2 2 0 26S proteasome regulatory subunit RPN6 N-terminal domain TPR_11 PF13414.6 CAV18245.1 - 3.9 7.2 6.9 1.8 8.3 0.2 3.1 3 2 2 5 5 5 0 TPR repeat NadA PF02445.16 CAV18246.1 - 1.5e-102 342.8 0.0 1.7e-102 342.6 0.0 1.0 1 0 0 1 1 1 1 Quinolinate synthetase A protein Plug PF07715.15 CAV18248.1 - 1.9e-10 41.2 1.3 4.8e-10 39.9 1.3 1.8 1 0 0 1 1 1 1 TonB-dependent Receptor Plug Domain SIP PF04954.13 CAV18249.1 - 1.3e-34 119.2 0.0 1.9e-34 118.7 0.0 1.2 1 0 0 1 1 1 1 Siderophore-interacting protein FAD_binding_9 PF08021.11 CAV18249.1 - 1.1e-31 109.5 0.0 1.6e-31 109.0 0.0 1.2 1 0 0 1 1 1 1 Siderophore-interacting FAD-binding domain Peripla_BP_2 PF01497.18 CAV18250.1 - 3.8e-16 59.4 0.1 4.6e-16 59.1 0.1 1.1 1 0 0 1 1 1 1 Periplasmic binding protein FecCD PF01032.18 CAV18251.1 - 5.5e-90 301.5 30.5 6.6e-90 301.3 30.5 1.0 1 0 0 1 1 1 1 FecCD transport family DUF1282 PF06930.12 CAV18251.1 - 0.84 9.4 13.6 0.12 12.1 6.0 2.9 1 1 0 2 2 2 0 Protein of unknown function (DUF1282) FecCD PF01032.18 CAV18252.1 - 5e-72 242.5 40.3 6.2e-72 242.2 40.3 1.1 1 0 0 1 1 1 1 FecCD transport family ABC_tran PF00005.27 CAV18253.1 - 2e-33 115.8 0.0 2.8e-33 115.3 0.0 1.2 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 CAV18253.1 - 1.2e-12 47.8 0.0 6.8e-06 25.7 0.0 2.1 1 1 1 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 CAV18253.1 - 9.1e-12 45.4 0.3 4.2e-05 23.5 0.0 2.1 1 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_15 PF13175.6 CAV18253.1 - 3.4e-08 33.6 0.0 8.6e-06 25.7 0.0 2.1 1 1 0 2 2 2 1 AAA ATPase domain AAA_16 PF13191.6 CAV18253.1 - 5.1e-07 30.2 0.4 2e-06 28.3 0.4 2.0 1 1 0 1 1 1 1 AAA ATPase domain AAA_23 PF13476.6 CAV18253.1 - 7.4e-07 29.9 0.0 9.9e-07 29.5 0.0 1.3 1 1 0 1 1 1 1 AAA domain AAA_29 PF13555.6 CAV18253.1 - 1.4e-05 24.7 0.0 2.9e-05 23.7 0.0 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain ATPase_2 PF01637.18 CAV18253.1 - 7.4e-05 22.8 0.0 0.00035 20.6 0.0 1.9 1 1 0 1 1 1 1 ATPase domain predominantly from Archaea AAA_22 PF13401.6 CAV18253.1 - 9.2e-05 22.7 0.2 0.00035 20.8 0.2 1.9 1 1 0 1 1 1 1 AAA domain NACHT PF05729.12 CAV18253.1 - 0.00012 22.1 0.4 0.0021 18.0 0.0 2.2 2 0 0 2 2 2 1 NACHT domain AAA_25 PF13481.6 CAV18253.1 - 0.00017 21.2 0.0 0.00062 19.4 0.0 1.9 2 0 0 2 2 2 1 AAA domain AAA_14 PF13173.6 CAV18253.1 - 0.00026 21.0 0.0 0.0022 18.0 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_27 PF13514.6 CAV18253.1 - 0.00035 20.2 0.0 0.0007 19.2 0.0 1.4 1 0 0 1 1 1 1 AAA domain RsgA_GTPase PF03193.16 CAV18253.1 - 0.00092 19.2 0.0 0.0017 18.3 0.0 1.4 1 0 0 1 1 1 1 RsgA GTPase AAA_33 PF13671.6 CAV18253.1 - 0.00094 19.4 0.0 0.0048 17.1 0.0 2.1 1 1 0 1 1 1 1 AAA domain ABC_ATPase PF09818.9 CAV18253.1 - 0.0012 17.7 0.0 0.024 13.4 0.0 2.1 2 0 0 2 2 2 1 Predicted ATPase of the ABC class RNA_helicase PF00910.22 CAV18253.1 - 0.0013 19.1 0.0 0.0074 16.7 0.0 2.0 2 0 0 2 2 2 1 RNA helicase AAA_5 PF07728.14 CAV18253.1 - 0.0018 18.3 0.1 0.01 15.8 0.0 2.1 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) Adeno_IVa2 PF02456.15 CAV18253.1 - 0.0018 17.1 0.1 0.0077 15.1 0.1 1.9 1 1 1 2 2 2 1 Adenovirus IVa2 protein Rad17 PF03215.15 CAV18253.1 - 0.0026 17.7 0.1 0.0045 16.9 0.1 1.3 1 0 0 1 1 1 1 Rad17 P-loop domain AAA_30 PF13604.6 CAV18253.1 - 0.0043 16.8 0.0 0.0062 16.3 0.0 1.5 1 1 0 1 1 1 1 AAA domain AAA PF00004.29 CAV18253.1 - 0.0078 16.6 0.0 0.019 15.4 0.0 1.8 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) MMR_HSR1 PF01926.23 CAV18253.1 - 0.013 15.6 0.1 0.04 14.0 0.1 2.0 1 1 0 1 1 1 0 50S ribosome-binding GTPase RNA12 PF10443.9 CAV18253.1 - 0.013 14.3 0.0 0.017 13.9 0.0 1.2 1 0 0 1 1 1 0 RNA12 protein Mg_chelatase PF01078.21 CAV18253.1 - 0.013 14.9 0.0 0.022 14.2 0.0 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI APS_kinase PF01583.20 CAV18253.1 - 0.016 15.1 0.0 0.027 14.4 0.0 1.3 1 0 0 1 1 1 0 Adenylylsulphate kinase AAA_7 PF12775.7 CAV18253.1 - 0.022 14.3 0.0 0.038 13.5 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region NYN PF01936.18 CAV18253.1 - 0.025 15.1 0.0 0.043 14.3 0.0 1.3 1 0 0 1 1 1 0 NYN domain AAA_18 PF13238.6 CAV18253.1 - 0.034 14.7 0.0 0.079 13.5 0.0 1.7 1 1 0 1 1 1 0 AAA domain cobW PF02492.19 CAV18253.1 - 0.039 13.6 0.1 0.09 12.4 0.1 1.6 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Viral_helicase1 PF01443.18 CAV18253.1 - 0.044 13.5 0.0 0.071 12.8 0.0 1.4 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase AAA_28 PF13521.6 CAV18253.1 - 0.045 14.0 0.0 0.1 12.8 0.0 1.6 1 0 0 1 1 1 0 AAA domain NTPase_1 PF03266.15 CAV18253.1 - 0.085 12.8 0.1 0.36 10.7 0.0 1.9 2 0 0 2 2 2 0 NTPase TniB PF05621.11 CAV18253.1 - 0.12 11.8 0.1 9.1 5.6 0.0 2.1 2 0 0 2 2 2 0 Bacterial TniB protein ATP-synt_ab PF00006.25 CAV18253.1 - 0.15 11.7 0.0 0.27 10.9 0.0 1.7 1 1 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain Importin_rep PF18773.1 CAV18253.1 - 0.15 11.8 0.1 0.24 11.1 0.1 1.3 1 0 0 1 1 1 0 Importin 13 repeat NB-ARC PF00931.22 CAV18253.1 - 0.18 11.0 0.1 0.67 9.1 0.0 1.8 2 0 0 2 2 2 0 NB-ARC domain Ion_trans_2 PF07885.16 CAV18254.1 - 7.7e-13 48.2 8.6 1.6e-12 47.2 8.6 1.4 1 0 0 1 1 1 1 Ion channel TrkA_N PF02254.18 CAV18254.1 - 0.0014 18.8 0.0 0.0023 18.2 0.0 1.3 1 0 0 1 1 1 1 TrkA-N domain Ion_trans PF00520.31 CAV18254.1 - 0.0053 16.0 1.9 0.0082 15.4 1.9 1.2 1 0 0 1 1 1 1 Ion transport protein UPF0149 PF03695.13 CAV18255.1 - 3.4e-34 118.6 4.0 4e-34 118.4 4.0 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0149) HATPase_c PF02518.26 CAV18256.1 - 6e-31 107.2 0.2 1.2e-30 106.3 0.2 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 CAV18256.1 - 1.3e-19 70.4 0.5 3.7e-19 69.0 0.2 2.0 2 0 0 2 2 2 1 Response regulator receiver domain HisKA PF00512.25 CAV18256.1 - 8.7e-18 64.1 0.0 4.6e-17 61.8 0.1 2.3 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain dCache_1 PF02743.18 CAV18256.1 - 8e-11 42.2 1.7 2.3e-10 40.7 1.7 1.8 1 0 0 1 1 1 1 Cache domain HAMP PF00672.25 CAV18256.1 - 1.1e-05 25.8 0.0 7.8e-05 23.0 0.0 2.3 2 0 0 2 2 2 1 HAMP domain HATPase_c_3 PF13589.6 CAV18256.1 - 0.00033 20.5 0.0 0.0007 19.4 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_5 PF14501.6 CAV18256.1 - 0.0031 17.4 0.0 0.0093 15.9 0.0 1.8 1 0 0 1 1 1 1 GHKL domain ARPC4 PF05856.12 CAV18256.1 - 0.038 13.6 0.2 0.11 12.1 0.1 1.8 2 0 0 2 2 2 0 ARP2/3 complex 20 kDa subunit (ARPC4) AlaE PF06610.13 CAV18257.1 - 1.7e-67 225.8 2.3 2e-67 225.6 2.3 1.0 1 0 0 1 1 1 1 L-alanine exporter LysR_substrate PF03466.20 CAV18258.1 - 1.6e-36 125.6 0.0 1.9e-36 125.4 0.0 1.1 1 0 0 1 1 1 1 LysR substrate binding domain HTH_1 PF00126.27 CAV18258.1 - 2.2e-11 43.5 0.1 5.3e-11 42.3 0.1 1.7 1 0 0 1 1 1 1 Bacterial regulatory helix-turn-helix protein, lysR family DUF5304 PF17230.2 CAV18258.1 - 0.0069 16.6 0.1 0.012 15.8 0.1 1.4 1 0 0 1 1 1 1 Family of unknown function (DUF5304) MarR PF01047.22 CAV18258.1 - 0.027 14.4 0.1 0.089 12.7 0.1 1.9 1 0 0 1 1 1 0 MarR family DAO PF01266.24 CAV18259.1 - 1.4e-73 248.5 0.0 1.7e-73 248.3 0.0 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 CAV18259.1 - 2.9e-12 46.4 0.0 5.2e-12 45.6 0.0 1.4 1 1 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 CAV18259.1 - 3.1e-09 36.5 0.2 0.0021 17.3 0.1 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 CAV18259.1 - 5.1e-09 36.6 0.5 3.6e-05 24.2 0.1 2.5 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 CAV18259.1 - 5.2e-09 35.3 0.0 0.0012 17.6 0.0 2.2 2 0 0 2 2 2 2 HI0933-like protein NAD_binding_8 PF13450.6 CAV18259.1 - 4.4e-08 33.3 0.0 1.2e-07 31.9 0.0 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_3 PF01494.19 CAV18259.1 - 5.1e-06 26.0 0.1 0.0011 18.3 0.0 2.3 2 0 0 2 2 2 2 FAD binding domain Pyr_redox_3 PF13738.6 CAV18259.1 - 1.8e-05 24.2 0.3 0.071 12.4 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 CAV18259.1 - 2.6e-05 23.5 0.1 0.028 13.5 0.0 2.2 2 0 0 2 2 2 2 Glucose inhibited division protein A UDPG_MGDP_dh_N PF03721.14 CAV18259.1 - 6.4e-05 22.6 0.1 0.00013 21.6 0.1 1.5 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain ApbA PF02558.16 CAV18259.1 - 7.7e-05 22.4 0.3 0.00021 21.0 0.1 1.9 3 0 0 3 3 3 1 Ketopantoate reductase PanE/ApbA Amino_oxidase PF01593.24 CAV18259.1 - 0.00024 20.5 0.0 0.11 11.8 0.0 2.3 2 0 0 2 2 2 2 Flavin containing amine oxidoreductase NAD_binding_9 PF13454.6 CAV18259.1 - 0.00083 19.4 1.1 1.3 8.9 0.1 2.4 1 1 0 2 2 2 2 FAD-NAD(P)-binding 3HCDH_N PF02737.18 CAV18259.1 - 0.001 19.0 0.1 0.0023 17.8 0.1 1.6 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Thi4 PF01946.17 CAV18259.1 - 0.0011 18.3 0.1 0.0018 17.6 0.1 1.3 1 0 0 1 1 1 1 Thi4 family AlaDh_PNT_C PF01262.21 CAV18259.1 - 0.0036 16.6 0.0 0.0065 15.8 0.0 1.4 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain FAD_oxidored PF12831.7 CAV18259.1 - 0.0046 16.4 0.0 0.16 11.2 0.0 2.1 2 0 0 2 2 2 1 FAD dependent oxidoreductase Trp_halogenase PF04820.14 CAV18259.1 - 0.0081 15.1 0.6 1.9 7.2 0.0 2.3 2 0 0 2 2 2 2 Tryptophan halogenase Sacchrp_dh_NADP PF03435.18 CAV18259.1 - 0.017 15.4 0.1 0.049 13.9 0.1 1.8 2 0 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain MCRA PF06100.11 CAV18259.1 - 0.023 13.5 0.6 0.18 10.6 0.1 2.2 3 0 0 3 3 3 0 MCRA family NAD_binding_2 PF03446.15 CAV18259.1 - 0.033 14.4 0.0 0.1 12.8 0.0 1.9 2 0 0 2 2 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase TrkA_N PF02254.18 CAV18259.1 - 0.049 13.9 0.1 0.13 12.5 0.1 1.7 1 0 0 1 1 1 0 TrkA-N domain NAD_binding_7 PF13241.6 CAV18259.1 - 0.055 13.9 0.0 0.12 12.8 0.0 1.7 1 0 0 1 1 1 0 Putative NAD(P)-binding Glu_dehyd_C PF16912.5 CAV18259.1 - 0.1 12.1 0.0 0.18 11.3 0.0 1.4 1 0 0 1 1 1 0 Glucose dehydrogenase C-terminus DLH PF01738.18 CAV18260.1 - 8.9e-35 120.2 0.0 1.1e-34 119.9 0.0 1.0 1 0 0 1 1 1 1 Dienelactone hydrolase family Peptidase_S9 PF00326.21 CAV18260.1 - 2.8e-06 27.0 0.8 0.00092 18.7 0.1 2.2 1 1 0 2 2 2 2 Prolyl oligopeptidase family Hydrolase_4 PF12146.8 CAV18260.1 - 5.9e-05 22.5 0.1 0.2 10.9 0.0 2.2 1 1 0 2 2 2 2 Serine aminopeptidase, S33 PAF-AH_p_II PF03403.13 CAV18260.1 - 0.04 12.4 0.0 0.054 12.0 0.0 1.1 1 0 0 1 1 1 0 Platelet-activating factor acetylhydrolase, isoform II PALP PF00291.25 CAV18261.1 - 1e-09 38.3 0.0 1.3e-09 37.9 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Imm49 PF15575.6 CAV18261.1 - 0.047 13.5 0.0 0.075 12.8 0.0 1.3 1 0 0 1 1 1 0 Immunity protein 49 HisKA PF00512.25 CAV18262.1 - 2.2e-10 40.4 0.8 6e-10 39.0 0.4 2.1 1 1 1 2 2 2 1 His Kinase A (phospho-acceptor) domain HATPase_c PF02518.26 CAV18262.1 - 1.4e-06 28.8 0.1 4.2e-06 27.2 0.1 1.8 1 1 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_5 PF14501.6 CAV18262.1 - 0.045 13.6 0.2 1.7 8.6 0.2 2.4 1 1 0 1 1 1 0 GHKL domain HATPase_c_3 PF13589.6 CAV18262.1 - 0.049 13.5 0.3 0.18 11.6 0.1 1.9 2 0 0 2 2 2 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Bys1 PF04681.12 CAV18262.1 - 0.19 11.6 0.1 9.1 6.2 0.0 2.2 2 0 0 2 2 2 0 Blastomyces yeast-phase-specific protein Response_reg PF00072.24 CAV18263.1 - 1.3e-25 89.7 0.1 4.6e-25 88.0 0.1 1.8 2 0 0 2 2 2 1 Response regulator receiver domain Trans_reg_C PF00486.28 CAV18263.1 - 1.1e-17 63.9 0.0 3e-17 62.5 0.0 1.7 2 0 0 2 2 2 1 Transcriptional regulatory protein, C terminal Glycos_transf_2 PF00535.26 CAV18264.1 - 9.9e-30 103.6 0.0 1.5e-29 103.0 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 CAV18264.1 - 5.7e-08 32.9 0.0 7.5e-08 32.5 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_2 PF10111.9 CAV18264.1 - 7.2e-06 25.7 0.0 1.4e-05 24.8 0.0 1.4 2 0 0 2 2 2 1 Glycosyltransferase like family 2 Glyco_transf_21 PF13506.6 CAV18264.1 - 0.00012 21.6 0.0 0.00017 21.1 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 21 PMT PF02366.18 CAV18265.1 - 2.8e-18 66.4 16.0 2.8e-18 66.4 16.0 2.0 2 1 0 2 2 2 1 Dolichyl-phosphate-mannose-protein mannosyltransferase PMT_2 PF13231.6 CAV18265.1 - 1.1e-13 51.8 15.7 1.1e-13 51.8 15.7 2.9 3 1 0 3 3 3 1 Dolichyl-phosphate-mannose-protein mannosyltransferase GtrA PF04138.14 CAV18266.1 - 7.3e-22 77.8 11.3 8.9e-22 77.5 11.3 1.1 1 0 0 1 1 1 1 GtrA-like protein SLATT_1 PF18181.1 CAV18266.1 - 0.00087 19.2 0.8 0.004 17.1 0.0 1.9 2 0 0 2 2 2 1 SMODS and SLOG-associating 2TM effector domain 1 DUF2062 PF09835.9 CAV18266.1 - 0.084 12.7 10.2 0.27 11.1 10.2 1.8 1 1 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2062) ECF_trnsprt PF12822.7 CAV18266.1 - 0.2 11.8 10.7 1 9.5 0.8 2.1 1 1 0 2 2 2 0 ECF transporter, substrate-specific component FtsX PF02687.21 CAV18266.1 - 1.1 9.7 7.5 6.9 7.2 1.3 2.2 1 1 1 2 2 2 0 FtsX-like permease family DUF4235 PF14019.6 CAV18266.1 - 3.8 7.6 6.4 4.5 7.4 0.1 3.2 3 1 0 3 3 3 0 Protein of unknown function (DUF4235) SNARE_assoc PF09335.11 CAV18266.1 - 8.7 6.9 12.3 2.2 8.8 2.4 2.7 1 1 1 2 2 2 0 SNARE associated Golgi protein Radical_SAM_N PF08497.10 CAV18267.1 - 8.2e-141 468.5 0.0 1.2e-140 468.0 0.0 1.2 1 0 0 1 1 1 1 Radical SAM N-terminal DUF3362 PF11842.8 CAV18267.1 - 5.6e-43 146.8 4.3 1.7e-42 145.3 4.3 1.9 1 1 0 1 1 1 1 Domain of unknown function (DUF3362) Radical_SAM PF04055.21 CAV18267.1 - 5.6e-19 69.1 0.1 1.2e-18 68.0 0.1 1.6 1 0 0 1 1 1 1 Radical SAM superfamily B12-binding PF02310.19 CAV18267.1 - 0.021 14.8 0.0 0.51 10.4 0.0 2.4 2 0 0 2 2 2 0 B12 binding domain DUF1129 PF06570.11 CAV18268.1 - 0.057 12.9 11.6 0.077 12.5 8.0 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1129) DUF2304 PF10066.9 CAV18268.1 - 0.22 11.8 18.2 0.59 10.4 3.1 2.5 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2304) PHO4 PF01384.20 CAV18268.1 - 0.58 9.1 14.0 0.13 11.3 8.8 2.0 1 1 1 2 2 2 0 Phosphate transporter family TssN PF17555.2 CAV18268.1 - 8 5.8 13.6 11 5.3 13.6 1.2 1 0 0 1 1 1 0 Type VI secretion system, TssN Bax1-I PF01027.20 CAV18268.1 - 9.1 6.0 26.2 5.7 6.7 9.7 2.1 1 1 1 2 2 2 0 Inhibitor of apoptosis-promoting Bax1 DUF4250 PF14056.6 CAV18269.1 - 5.8e-18 64.6 0.3 7.2e-18 64.3 0.3 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4250) LysR_substrate PF03466.20 CAV18270.1 - 4.1e-38 130.8 0.0 5e-38 130.6 0.0 1.1 1 0 0 1 1 1 1 LysR substrate binding domain HTH_1 PF00126.27 CAV18270.1 - 1.3e-16 60.3 1.5 2.6e-16 59.3 1.5 1.5 1 0 0 1 1 1 1 Bacterial regulatory helix-turn-helix protein, lysR family HTH_5 PF01022.20 CAV18270.1 - 0.013 15.3 0.6 0.034 14.0 0.6 1.8 1 0 0 1 1 1 0 Bacterial regulatory protein, arsR family MarR PF01047.22 CAV18270.1 - 0.11 12.4 1.2 0.33 10.9 1.2 1.9 1 0 0 1 1 1 0 MarR family HTH_30 PF13556.6 CAV18270.1 - 0.14 12.0 1.5 0.26 11.1 1.5 1.5 1 0 0 1 1 1 0 PucR C-terminal helix-turn-helix domain Meth_synt_2 PF01717.18 CAV18271.1 - 7e-155 515.2 0.0 1.7e-148 494.2 0.0 2.3 2 0 0 2 2 2 2 Cobalamin-independent synthase, Catalytic domain Meth_synt_1 PF08267.12 CAV18271.1 - 1.4e-128 428.8 0.0 2e-117 392.2 0.0 2.8 3 0 0 3 3 3 2 Cobalamin-independent synthase, N-terminal domain T2SSS_2 PF16549.5 CAV18272.1 - 2.7e-45 152.6 0.8 3.2e-45 152.4 0.8 1.1 1 0 0 1 1 1 1 Type II secretion system (T2SS) pilotin, S protein YCII PF03795.14 CAV18273.1 - 1.3e-28 99.3 0.0 1.4e-28 99.1 0.0 1.0 1 0 0 1 1 1 1 YCII-related domain DUF1330 PF07045.11 CAV18273.1 - 0.0091 16.3 0.0 0.013 15.8 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1330) 4HBT PF03061.22 CAV18274.1 - 2.1e-17 63.3 0.0 3.2e-17 62.6 0.0 1.3 1 0 0 1 1 1 1 Thioesterase superfamily MaoC_dehydratas PF01575.19 CAV18274.1 - 0.086 12.4 0.0 0.18 11.4 0.0 1.5 2 0 0 2 2 2 0 MaoC like domain IspA PF04279.15 CAV18275.1 - 9.2e-68 227.9 21.8 1.1e-67 227.7 21.8 1.0 1 0 0 1 1 1 1 Intracellular septation protein A TMEM220 PF15071.6 CAV18275.1 - 0.066 14.0 2.9 0.52 11.1 0.0 2.6 2 1 0 2 2 2 0 Transmembrane family 220, helix DUF1018 PF06252.12 CAV18276.1 - 0.0018 19.3 0.1 0.002 19.1 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1018) LysR_substrate PF03466.20 CAV18277.1 - 7.8e-25 87.5 0.0 1.3e-24 86.7 0.0 1.4 2 0 0 2 2 2 1 LysR substrate binding domain HTH_1 PF00126.27 CAV18277.1 - 6.1e-18 64.5 0.3 1.2e-17 63.5 0.3 1.6 1 0 0 1 1 1 1 Bacterial regulatory helix-turn-helix protein, lysR family Aminotran_1_2 PF00155.21 CAV18278.1 - 9.7e-44 150.0 0.0 1.2e-43 149.7 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II FBPase PF00316.20 CAV18278.1 - 0.083 12.4 0.0 0.36 10.3 0.0 1.9 2 0 0 2 2 2 0 Fructose-1-6-bisphosphatase, N-terminal domain SBP_bac_3 PF00497.20 CAV18279.1 - 1.1e-57 195.1 0.7 1.2e-57 194.9 0.7 1.0 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 Lig_chan-Glu_bd PF10613.9 CAV18279.1 - 1.4e-06 28.5 0.0 3.1e-06 27.4 0.0 1.6 1 0 0 1 1 1 1 Ligated ion channel L-glutamate- and glycine-binding site SBP_bac_3 PF00497.20 CAV18281.1 - 2.8e-28 98.9 0.0 5.5e-14 52.1 0.0 2.9 3 0 0 3 3 3 2 Bacterial extracellular solute-binding proteins, family 3 HATPase_c PF02518.26 CAV18281.1 - 2.4e-27 95.7 0.2 6.5e-27 94.3 0.2 1.8 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 CAV18281.1 - 2.3e-25 88.9 4.1 2.3e-25 88.9 0.4 2.9 3 0 0 3 3 3 1 Response regulator receiver domain HisKA PF00512.25 CAV18281.1 - 7.3e-16 58.0 0.4 2.6e-15 56.2 0.1 2.3 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain Hpt PF01627.23 CAV18281.1 - 9.3e-10 38.6 2.5 1.3e-09 38.2 0.7 2.2 2 0 0 2 2 2 1 Hpt domain PAS_8 PF13188.7 CAV18281.1 - 1.1e-06 28.5 0.2 1.7e-05 24.7 0.0 2.9 3 0 0 3 3 3 1 PAS domain PAS PF00989.25 CAV18281.1 - 0.00015 21.7 0.1 0.0051 16.8 0.0 3.1 3 0 0 3 3 3 1 PAS fold PAS_9 PF13426.7 CAV18281.1 - 0.00062 20.0 0.0 1.8 8.9 0.0 3.1 2 0 0 2 2 2 2 PAS domain HATPase_c_3 PF13589.6 CAV18281.1 - 0.0087 15.9 0.0 0.022 14.6 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_5 PF14501.6 CAV18281.1 - 0.036 14.0 0.0 0.15 12.0 0.0 2.1 1 0 0 1 1 1 0 GHKL domain EAL PF00563.20 CAV18282.1 - 2.3e-49 168.0 0.3 5.3e-49 166.9 0.1 1.6 2 0 0 2 2 2 1 EAL domain Response_reg PF00072.24 CAV18282.1 - 1.1e-22 80.3 0.1 3.3e-22 78.8 0.1 1.9 1 0 0 1 1 1 1 Response regulator receiver domain MCPsignal PF00015.21 CAV18283.1 - 3.4e-40 137.7 18.7 3.4e-40 137.7 18.7 4.1 2 2 2 4 4 4 2 Methyl-accepting chemotaxis protein (MCP) signalling domain HAMP PF00672.25 CAV18283.1 - 7.3e-11 42.3 0.3 1.8e-09 37.9 0.0 3.5 4 0 0 4 4 3 1 HAMP domain Serine_rich PF08824.10 CAV18283.1 - 0.0003 20.8 14.7 0.26 11.3 1.5 3.6 3 0 0 3 3 3 3 Serine rich protein interaction domain Mce4_CUP1 PF11887.8 CAV18283.1 - 0.0014 18.1 18.1 0.0021 17.6 1.4 3.4 3 1 0 3 3 3 1 Cholesterol uptake porter CUP1 of Mce4, putative DUF4200 PF13863.6 CAV18283.1 - 0.008 16.6 8.6 0.16 12.4 1.3 3.3 3 0 0 3 3 3 1 Domain of unknown function (DUF4200) DUF1403 PF07183.11 CAV18283.1 - 0.013 15.1 5.6 1 8.9 0.9 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF1403) BLOC1_2 PF10046.9 CAV18283.1 - 0.015 15.6 21.1 0.34 11.2 3.1 5.2 3 2 2 5 5 5 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 FAM92 PF06730.11 CAV18283.1 - 0.018 14.5 3.4 0.025 14.0 1.8 2.0 2 0 0 2 2 2 0 FAM92 protein Fungal_trans_2 PF11951.8 CAV18283.1 - 0.018 13.8 0.1 0.018 13.8 0.1 2.3 2 0 0 2 2 2 0 Fungal specific transcription factor domain GAS PF13851.6 CAV18283.1 - 0.027 13.8 14.2 0.095 12.0 0.3 3.8 3 2 0 3 3 3 0 Growth-arrest specific micro-tubule binding DHR10 PF18595.1 CAV18283.1 - 0.032 14.3 1.0 0.032 14.3 1.0 4.3 3 1 1 4 4 3 0 Designed helical repeat protein 10 domain DUF2203 PF09969.9 CAV18283.1 - 0.033 14.9 18.6 0.98 10.2 1.5 4.9 3 2 1 4 4 4 0 Uncharacterized conserved protein (DUF2203) Laminin_II PF06009.12 CAV18283.1 - 0.083 12.9 27.6 0.55 10.3 7.7 4.4 3 2 0 4 4 4 0 Laminin Domain II Goodbye PF17109.5 CAV18283.1 - 0.12 12.8 8.2 1.1 9.7 2.4 3.8 2 1 1 3 3 3 0 fungal STAND N-terminal Goodbye domain DUF948 PF06103.11 CAV18283.1 - 0.43 10.9 28.8 2.7 8.3 0.8 6.2 1 1 4 5 5 5 0 Bacterial protein of unknown function (DUF948) Snapin_Pallidin PF14712.6 CAV18283.1 - 0.48 10.9 12.9 2.4 8.6 1.8 4.3 3 1 1 4 4 4 0 Snapin/Pallidin Jnk-SapK_ap_N PF09744.9 CAV18283.1 - 0.81 9.9 19.3 1.7 8.8 1.8 4.0 3 1 1 4 4 4 0 JNK_SAPK-associated protein-1 KxDL PF10241.9 CAV18283.1 - 1.1 9.6 11.1 13 6.2 1.8 4.0 3 1 0 3 3 3 0 Uncharacterized conserved protein DASH_Dad2 PF08654.10 CAV18283.1 - 1.1 9.7 18.5 0.58 10.6 0.9 4.9 3 2 1 4 4 4 0 DASH complex subunit Dad2 NPV_P10 PF05531.12 CAV18283.1 - 1.1 9.7 22.1 1.7 9.2 0.3 5.8 3 2 2 6 6 6 0 Nucleopolyhedrovirus P10 protein SlyX PF04102.12 CAV18283.1 - 1.2 9.8 12.8 25 5.6 0.1 5.2 4 2 1 5 5 4 0 SlyX Seryl_tRNA_N PF02403.22 CAV18283.1 - 1.3 9.3 18.4 4.2 7.7 0.6 5.0 4 2 1 5 5 5 0 Seryl-tRNA synthetase N-terminal domain Sec34 PF04136.15 CAV18283.1 - 1.7 8.6 29.7 0.66 9.8 0.4 5.0 4 2 1 5 5 5 0 Sec34-like family Cauli_DNA-bind PF03310.13 CAV18283.1 - 1.7 8.7 11.3 18 5.4 0.4 3.8 3 1 0 3 3 3 0 Caulimovirus DNA-binding protein RmuC PF02646.16 CAV18283.1 - 3.1 6.9 22.3 0.32 10.1 1.3 4.7 4 1 1 6 6 6 0 RmuC family IFT46_B_C PF12317.8 CAV18283.1 - 3.3 7.4 7.5 1.8 8.2 0.3 2.5 2 0 0 2 2 2 0 Intraflagellar transport complex B protein 46 C terminal DUF3958 PF13125.6 CAV18283.1 - 3.5 7.9 8.4 5.9 7.2 0.0 3.4 4 0 0 4 4 3 0 Protein of unknown function (DUF3958) TMPIT PF07851.13 CAV18283.1 - 3.8 6.7 19.9 1.1 8.4 1.9 3.5 3 1 0 3 3 3 0 TMPIT-like protein zf-C4H2 PF10146.9 CAV18283.1 - 4.2 7.6 13.2 1.7 8.9 1.6 3.0 3 1 0 3 3 3 0 Zinc finger-containing protein Plk4_PB2 PF18409.1 CAV18283.1 - 4.8 7.9 16.9 16 6.2 1.2 5.2 3 2 3 6 6 6 0 Polo-like Kinase 4 Polo Box 2 CHASE3 PF05227.13 CAV18283.1 - 8 6.4 23.6 0.2 11.6 1.3 4.5 3 1 2 5 5 5 0 CHASE3 domain TetR_N PF00440.23 CAV18286.1 - 5.4e-15 54.9 0.0 8.2e-15 54.3 0.0 1.3 1 0 0 1 1 1 1 Bacterial regulatory proteins, tetR family DUF615 PF04751.14 CAV18286.1 - 0.085 12.8 0.0 0.16 12.0 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF615) CDP-OH_P_transf PF01066.21 CAV18287.1 - 7.9e-11 42.6 1.1 7.9e-11 42.6 1.1 2.4 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase ABC_tran PF00005.27 CAV18288.1 - 2.2e-31 109.2 0.0 2.8e-31 108.8 0.0 1.1 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 CAV18288.1 - 9.4e-07 28.9 0.2 0.015 15.1 0.0 2.1 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system Rad17 PF03215.15 CAV18288.1 - 4e-06 26.9 0.0 3.4e-05 23.8 0.0 2.0 1 1 0 1 1 1 1 Rad17 P-loop domain AAA_29 PF13555.6 CAV18288.1 - 4.9e-06 26.2 0.1 9.1e-06 25.3 0.1 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_16 PF13191.6 CAV18288.1 - 9.9e-06 26.0 0.1 1.5e-05 25.4 0.1 1.5 1 1 0 1 1 1 1 AAA ATPase domain RsgA_GTPase PF03193.16 CAV18288.1 - 4.4e-05 23.4 0.1 9.6e-05 22.3 0.1 1.5 1 0 0 1 1 1 1 RsgA GTPase SMC_N PF02463.19 CAV18288.1 - 0.00015 21.3 0.0 0.015 14.8 0.0 2.1 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 CAV18288.1 - 0.00095 19.7 0.0 0.0011 19.5 0.0 1.3 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.6 CAV18288.1 - 0.0019 18.5 0.0 0.0063 16.8 0.0 1.8 2 1 0 2 2 2 1 AAA domain AAA_33 PF13671.6 CAV18288.1 - 0.002 18.3 0.0 0.0041 17.3 0.0 1.6 1 1 0 1 1 1 1 AAA domain AAA PF00004.29 CAV18288.1 - 0.0023 18.3 0.0 0.0046 17.4 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_7 PF12775.7 CAV18288.1 - 0.0027 17.2 0.0 0.0063 16.0 0.0 1.6 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_17 PF13207.6 CAV18288.1 - 0.0083 16.6 0.0 0.045 14.2 0.0 2.0 2 1 0 2 2 2 1 AAA domain T2SSE PF00437.20 CAV18288.1 - 0.01 14.9 0.0 0.014 14.5 0.0 1.2 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_30 PF13604.6 CAV18288.1 - 0.01 15.5 0.0 0.022 14.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain cobW PF02492.19 CAV18288.1 - 0.012 15.3 0.0 0.017 14.7 0.0 1.2 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA_5 PF07728.14 CAV18288.1 - 0.013 15.5 0.0 0.025 14.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) SbcCD_C PF13558.6 CAV18288.1 - 0.013 15.7 0.1 0.033 14.4 0.1 1.7 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit NACHT PF05729.12 CAV18288.1 - 0.015 15.2 0.0 0.067 13.1 0.0 1.9 2 0 0 2 2 2 0 NACHT domain AAA_PrkA PF08298.11 CAV18288.1 - 0.016 14.1 0.0 0.023 13.6 0.0 1.2 1 0 0 1 1 1 0 PrkA AAA domain AAA_25 PF13481.6 CAV18288.1 - 0.017 14.7 0.0 0.039 13.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 CAV18288.1 - 0.019 15.5 0.0 0.034 14.7 0.0 1.6 2 0 0 2 2 1 0 AAA domain RNA_helicase PF00910.22 CAV18288.1 - 0.022 15.1 0.0 0.036 14.5 0.0 1.4 1 0 0 1 1 1 0 RNA helicase NB-ARC PF00931.22 CAV18288.1 - 0.027 13.7 0.0 0.032 13.4 0.0 1.4 1 1 0 1 1 1 0 NB-ARC domain Mg_chelatase PF01078.21 CAV18288.1 - 0.036 13.4 0.0 0.39 10.1 0.0 2.0 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_28 PF13521.6 CAV18288.1 - 0.039 14.2 0.0 0.16 12.2 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_14 PF13173.6 CAV18288.1 - 0.042 13.9 0.0 0.078 13.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain Cytidylate_kin PF02224.18 CAV18288.1 - 0.057 13.1 0.0 0.087 12.5 0.0 1.2 1 0 0 1 1 1 0 Cytidylate kinase DUF815 PF05673.13 CAV18288.1 - 0.06 12.5 0.0 0.092 11.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) RuvB_N PF05496.12 CAV18288.1 - 0.065 13.0 0.0 0.094 12.5 0.0 1.2 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain NTPase_1 PF03266.15 CAV18288.1 - 0.065 13.1 0.0 0.16 11.9 0.0 1.6 2 0 0 2 2 2 0 NTPase ATPase_2 PF01637.18 CAV18288.1 - 0.088 12.7 0.0 0.14 12.0 0.0 1.3 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea MeaB PF03308.16 CAV18288.1 - 0.098 11.6 0.0 0.12 11.3 0.0 1.2 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Dynamin_N PF00350.23 CAV18288.1 - 0.11 12.6 0.0 0.19 11.8 0.0 1.4 1 1 0 1 1 1 0 Dynamin family PduV-EutP PF10662.9 CAV18288.1 - 0.13 12.0 0.0 0.22 11.3 0.0 1.3 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation Guanylate_kin PF00625.21 CAV18288.1 - 0.23 11.1 0.0 0.34 10.6 0.0 1.2 1 0 0 1 1 1 0 Guanylate kinase BPD_transp_1 PF00528.22 CAV18289.1 - 0.0045 16.7 47.1 0.005 16.6 14.2 3.6 1 1 3 4 4 4 2 Binding-protein-dependent transport system inner membrane component SBP_bac_8 PF13416.6 CAV18290.1 - 9.5e-25 88.0 0.7 9.5e-25 88.0 0.7 1.6 2 0 0 2 2 2 1 Bacterial extracellular solute-binding protein SBP_bac_6 PF13343.6 CAV18290.1 - 5.7e-09 35.7 0.1 9.4e-09 35.0 0.1 1.5 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_1 PF01547.25 CAV18290.1 - 1.9e-05 24.8 1.2 3.1e-05 24.1 0.9 1.6 1 1 0 1 1 1 1 Bacterial extracellular solute-binding protein META PF03724.16 CAV18291.1 - 4.8e-26 90.9 0.3 6.7e-26 90.4 0.3 1.2 1 0 0 1 1 1 1 META domain DUF1289 PF06945.13 CAV18292.1 - 2e-18 65.9 2.9 3e-18 65.3 2.9 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1289) DUF1289 PF06945.13 CAV18293.1 - 0.032 14.0 0.1 0.042 13.7 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1289) GCH_III PF05165.12 CAV18293.1 - 0.23 10.7 0.0 0.25 10.6 0.0 1.0 1 0 0 1 1 1 0 GTP cyclohydrolase III Thiamine_BP PF01910.17 CAV18294.1 - 2.3e-22 78.7 0.4 2.8e-22 78.4 0.4 1.1 1 0 0 1 1 1 1 Thiamine-binding protein FGase PF05013.12 CAV18296.1 - 0.089 13.0 0.0 0.11 12.7 0.0 1.2 1 0 0 1 1 1 0 N-formylglutamate amidohydrolase DEAD PF00270.29 CAV18298.1 - 4e-47 160.2 5.5 5e-47 159.9 2.4 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CAV18298.1 - 1.6e-30 105.7 0.5 1.2e-28 99.7 0.1 2.5 2 1 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 CAV18298.1 - 3.9e-09 36.7 0.3 1.1e-08 35.2 0.0 1.8 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit UTP25 PF06862.12 CAV18298.1 - 0.006 15.4 0.4 0.13 11.0 0.0 2.7 3 0 0 3 3 3 1 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 HEM4 PF02602.15 CAV18298.1 - 0.039 13.3 0.2 0.076 12.4 0.2 1.4 1 0 0 1 1 1 0 Uroporphyrinogen-III synthase HemD SBF_like PF13593.6 CAV18298.1 - 0.093 12.0 0.0 0.15 11.3 0.0 1.3 1 0 0 1 1 1 0 SBF-like CPA transporter family (DUF4137) LysE PF01810.18 CAV18299.1 - 3.4e-34 118.0 15.9 3.9e-34 117.8 15.9 1.0 1 0 0 1 1 1 1 LysE type translocator Tachylectin PF14517.6 CAV18299.1 - 0.06 12.9 0.0 0.081 12.5 0.0 1.2 1 0 0 1 1 1 0 Tachylectin NDUF_B12 PF08122.12 CAV18299.1 - 0.17 12.0 0.6 2.4 8.3 0.1 2.7 3 0 0 3 3 3 0 NADH-ubiquinone oxidoreductase B12 subunit family PilZ PF07238.14 CAV18300.1 - 0.0007 19.9 0.0 0.00086 19.6 0.0 1.1 1 0 0 1 1 1 1 PilZ domain Pepdidase_M14_N PF18027.1 CAV18301.1 - 2.4e-35 121.2 0.6 3.7e-35 120.6 0.6 1.3 1 0 0 1 1 1 1 Cytosolic carboxypeptidase N-terminal domain Peptidase_M14 PF00246.24 CAV18301.1 - 4.6e-22 79.2 0.0 1.6e-21 77.4 0.0 1.7 1 1 0 1 1 1 1 Zinc carboxypeptidase NifW PF03206.14 CAV18302.1 - 1.9e-05 25.1 0.0 3.5e-05 24.3 0.0 1.4 1 1 0 1 1 1 1 Nitrogen fixation protein NifW DUF2389 PF09493.10 CAV18303.1 - 5.4e-23 81.4 1.1 6.3e-23 81.2 1.1 1.1 1 0 0 1 1 1 1 Tryptophan-rich protein (DUF2389) S6PP PF05116.13 CAV18304.1 - 3.1e-56 190.7 0.1 4.1e-56 190.3 0.1 1.0 1 0 0 1 1 1 1 Sucrose-6F-phosphate phosphohydrolase Hydrolase_3 PF08282.12 CAV18304.1 - 1e-20 74.6 0.1 2.1e-15 57.2 0.0 2.3 1 1 1 2 2 2 2 haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 CAV18304.1 - 2.3e-05 24.8 0.0 0.0012 19.2 0.0 2.4 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 CAV18304.1 - 8.1e-05 23.1 0.4 0.003 18.0 0.4 2.6 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase ABC_tran PF00005.27 CAV18305.1 - 7.9e-35 120.4 0.0 1.3e-34 119.6 0.0 1.4 1 0 0 1 1 1 1 ABC transporter CBS PF00571.28 CAV18305.1 - 4.3e-10 39.9 0.4 9.6e-06 26.0 0.0 3.2 2 1 1 3 3 3 2 CBS domain AAA_21 PF13304.6 CAV18305.1 - 3.1e-05 23.9 0.0 0.097 12.5 0.0 2.3 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_16 PF13191.6 CAV18305.1 - 4.6e-05 23.9 0.1 9.8e-05 22.8 0.1 1.6 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 CAV18305.1 - 0.00041 20.6 0.4 0.0047 17.2 0.4 2.2 1 1 0 1 1 1 1 AAA domain ABC_ATPase PF09818.9 CAV18305.1 - 0.00054 18.9 0.1 0.5 9.1 0.1 2.2 2 0 0 2 2 2 2 Predicted ATPase of the ABC class AAA_29 PF13555.6 CAV18305.1 - 0.00078 19.1 0.1 0.0015 18.2 0.1 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 CAV18305.1 - 0.0013 18.7 0.0 0.0026 17.7 0.0 1.5 1 0 0 1 1 1 1 RsgA GTPase AAA_18 PF13238.6 CAV18305.1 - 0.01 16.4 0.0 0.039 14.5 0.0 2.0 2 0 0 2 2 2 0 AAA domain APS_kinase PF01583.20 CAV18305.1 - 0.013 15.4 0.0 0.026 14.4 0.0 1.5 1 0 0 1 1 1 0 Adenylylsulphate kinase SMC_N PF02463.19 CAV18305.1 - 0.017 14.5 0.3 0.11 12.0 0.3 2.0 1 1 0 1 1 1 0 RecF/RecN/SMC N terminal domain AAA_30 PF13604.6 CAV18305.1 - 0.023 14.4 0.0 0.051 13.3 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 CAV18305.1 - 0.027 14.6 0.0 0.061 13.5 0.0 1.6 1 0 0 1 1 1 0 AAA domain LPD23 PF18838.1 CAV18305.1 - 0.048 13.4 0.0 0.09 12.5 0.0 1.4 1 0 0 1 1 1 0 Large polyvalent protein associated domain 23 BCA_ABC_TP_C PF12399.8 CAV18305.1 - 0.05 13.5 0.1 0.12 12.4 0.1 1.7 1 0 0 1 1 1 0 Branched-chain amino acid ATP-binding cassette transporter AAA_5 PF07728.14 CAV18305.1 - 0.069 13.2 0.0 0.21 11.6 0.0 1.9 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) Zeta_toxin PF06414.12 CAV18305.1 - 0.072 12.4 0.0 0.44 9.8 0.0 2.2 2 0 0 2 2 2 0 Zeta toxin Adeno_IVa2 PF02456.15 CAV18305.1 - 0.084 11.7 0.0 0.13 11.1 0.0 1.2 1 0 0 1 1 1 0 Adenovirus IVa2 protein DUF87 PF01935.17 CAV18305.1 - 0.12 12.5 0.1 0.26 11.3 0.1 1.5 1 0 0 1 1 1 0 Helicase HerA, central domain ATPase_2 PF01637.18 CAV18305.1 - 0.12 12.2 0.0 0.79 9.6 0.0 2.3 3 0 0 3 3 3 0 ATPase domain predominantly from Archaea AAA_23 PF13476.6 CAV18305.1 - 0.12 12.8 0.1 0.32 11.5 0.1 1.6 1 0 0 1 1 1 0 AAA domain SbcCD_C PF13558.6 CAV18305.1 - 0.22 11.8 0.7 1.1 9.6 0.7 2.2 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit BPD_transp_1 PF00528.22 CAV18306.1 - 8e-25 87.6 15.7 8e-25 87.6 15.7 2.2 2 0 0 2 2 2 1 Binding-protein-dependent transport system inner membrane component OpuAC PF04069.12 CAV18307.1 - 1.2e-51 175.8 1.7 1.4e-51 175.6 1.7 1.1 1 0 0 1 1 1 1 Substrate binding domain of ABC-type glycine betaine transport system SnoaL_2 PF12680.7 CAV18308.1 - 1.6e-08 35.1 0.2 2.4e-08 34.6 0.2 1.3 1 1 0 1 1 1 1 SnoaL-like domain DUF4440 PF14534.6 CAV18308.1 - 0.00033 21.0 0.1 0.0018 18.7 0.0 1.9 1 1 0 2 2 2 1 Domain of unknown function (DUF4440) SnoaL_3 PF13474.6 CAV18308.1 - 0.00099 19.4 0.3 0.0015 18.8 0.3 1.3 1 0 0 1 1 1 1 SnoaL-like domain NTF2 PF02136.20 CAV18308.1 - 0.0012 19.4 0.0 0.0023 18.5 0.0 1.5 1 0 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain SnoaL_4 PF13577.6 CAV18308.1 - 0.0023 18.0 0.1 0.0032 17.6 0.1 1.2 1 0 0 1 1 1 1 SnoaL-like domain DUF1348 PF07080.11 CAV18308.1 - 0.014 15.3 0.2 0.034 14.1 0.2 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF1348) SnoaL PF07366.12 CAV18308.1 - 0.021 14.6 0.0 0.029 14.2 0.0 1.3 1 0 0 1 1 1 0 SnoaL-like polyketide cyclase LysR_substrate PF03466.20 CAV18309.1 - 8.4e-22 77.6 0.0 1.2e-21 77.1 0.0 1.2 1 0 0 1 1 1 1 LysR substrate binding domain HTH_1 PF00126.27 CAV18309.1 - 9.3e-18 63.9 1.2 9.3e-18 63.9 1.2 1.6 2 0 0 2 2 2 1 Bacterial regulatory helix-turn-helix protein, lysR family HTH_5 PF01022.20 CAV18309.1 - 0.00012 21.8 0.3 0.00012 21.8 0.3 2.2 3 0 0 3 3 3 1 Bacterial regulatory protein, arsR family HTH_20 PF12840.7 CAV18309.1 - 0.00061 19.8 0.1 0.0013 18.7 0.1 1.6 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_30 PF13556.6 CAV18309.1 - 0.0031 17.3 0.0 0.0071 16.1 0.0 1.6 1 0 0 1 1 1 1 PucR C-terminal helix-turn-helix domain HTH_28 PF13518.6 CAV18309.1 - 0.025 14.7 0.0 0.048 13.8 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain MarR_2 PF12802.7 CAV18309.1 - 0.033 14.1 0.0 0.059 13.3 0.0 1.4 1 0 0 1 1 1 0 MarR family HTH_24 PF13412.6 CAV18309.1 - 0.049 13.2 0.1 0.16 11.6 0.1 1.9 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding HTH_11 PF08279.12 CAV18309.1 - 0.097 12.6 0.1 0.21 11.6 0.1 1.5 1 0 0 1 1 1 0 HTH domain ABC_tran PF00005.27 CAV18310.1 - 9.6e-31 107.1 0.1 1.5e-30 106.5 0.1 1.3 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 CAV18310.1 - 2e-08 34.4 1.1 0.00056 19.8 0.2 2.4 1 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 CAV18310.1 - 3.8e-08 33.0 0.0 3.1e-05 23.5 0.0 2.2 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain ABC_membrane PF00664.23 CAV18310.1 - 5e-08 32.9 3.9 8e-08 32.3 3.9 1.4 1 1 0 1 1 1 1 ABC transporter transmembrane region AAA_16 PF13191.6 CAV18310.1 - 0.0008 19.8 0.0 0.0015 19.0 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain DUF87 PF01935.17 CAV18310.1 - 0.00099 19.3 0.0 0.0021 18.2 0.0 1.5 1 0 0 1 1 1 1 Helicase HerA, central domain AAA_29 PF13555.6 CAV18310.1 - 0.0014 18.3 0.0 0.004 16.9 0.0 1.7 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_30 PF13604.6 CAV18310.1 - 0.002 17.9 0.0 0.0034 17.1 0.0 1.3 1 0 0 1 1 1 1 AAA domain MMR_HSR1 PF01926.23 CAV18310.1 - 0.0032 17.5 0.0 0.0082 16.2 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase Zeta_toxin PF06414.12 CAV18310.1 - 0.004 16.5 0.0 0.0072 15.6 0.0 1.3 1 0 0 1 1 1 1 Zeta toxin AAA_7 PF12775.7 CAV18310.1 - 0.0097 15.4 0.0 0.016 14.7 0.0 1.2 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_23 PF13476.6 CAV18310.1 - 0.012 16.1 0.1 0.023 15.2 0.1 1.3 1 0 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 CAV18310.1 - 0.019 14.9 0.0 0.035 14.0 0.0 1.4 1 0 0 1 1 1 0 RsgA GTPase NACHT PF05729.12 CAV18310.1 - 0.041 13.8 0.1 0.082 12.8 0.1 1.5 1 0 0 1 1 1 0 NACHT domain AAA_18 PF13238.6 CAV18310.1 - 0.042 14.4 0.0 0.088 13.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 CAV18310.1 - 0.047 14.0 0.0 0.12 12.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain Roc PF08477.13 CAV18310.1 - 0.054 13.7 0.0 0.091 13.0 0.0 1.4 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase FtsK_SpoIIIE PF01580.18 CAV18310.1 - 0.06 12.7 0.0 0.1 12.0 0.0 1.3 1 0 0 1 1 1 0 FtsK/SpoIIIE family ABC_membrane PF00664.23 CAV18311.1 - 1.3e-41 143.0 8.6 2.1e-41 142.4 8.6 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 CAV18311.1 - 5.1e-27 95.1 0.0 8.7e-27 94.3 0.0 1.4 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 CAV18311.1 - 2.1e-06 27.3 0.2 0.047 13.1 0.0 2.3 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain RsgA_GTPase PF03193.16 CAV18311.1 - 3.5e-05 23.8 0.0 7.2e-05 22.8 0.0 1.5 1 0 0 1 1 1 1 RsgA GTPase AAA_21 PF13304.6 CAV18311.1 - 0.0014 18.5 1.0 0.021 14.6 0.3 2.5 2 1 0 3 3 3 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 CAV18311.1 - 0.0015 18.2 0.1 0.0034 17.1 0.1 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_23 PF13476.6 CAV18311.1 - 0.002 18.6 0.0 0.0043 17.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain MMR_HSR1 PF01926.23 CAV18311.1 - 0.016 15.3 0.2 0.055 13.6 0.1 1.9 2 0 0 2 2 2 0 50S ribosome-binding GTPase AAA_16 PF13191.6 CAV18311.1 - 0.025 15.0 0.0 0.063 13.7 0.0 1.7 1 0 0 1 1 1 0 AAA ATPase domain AAA_22 PF13401.6 CAV18311.1 - 0.037 14.3 0.0 0.098 12.9 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 CAV18311.1 - 0.038 13.5 0.0 0.087 12.3 0.0 1.6 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA PF00004.29 CAV18311.1 - 0.04 14.3 0.0 0.098 13.1 0.0 1.7 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_30 PF13604.6 CAV18311.1 - 0.14 11.8 0.1 0.46 10.2 0.0 1.8 2 0 0 2 2 2 0 AAA domain S_4TM PF18159.1 CAV18311.1 - 0.15 11.4 0.1 0.15 11.4 0.1 2.0 2 1 1 3 3 3 0 SMODS-associating 4TM effector domain Dynamin_N PF00350.23 CAV18311.1 - 0.16 12.0 0.0 0.28 11.2 0.0 1.4 1 0 0 1 1 1 0 Dynamin family Zeta_toxin PF06414.12 CAV18311.1 - 0.19 11.0 0.0 0.39 10.0 0.0 1.5 1 0 0 1 1 1 0 Zeta toxin Roc PF08477.13 CAV18311.1 - 0.19 12.0 0.3 1.2 9.3 0.0 2.3 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase cobW PF02492.19 CAV18311.1 - 0.19 11.3 0.1 0.34 10.5 0.1 1.4 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain PGPGW PF09656.10 CAV18311.1 - 0.4 10.2 4.8 0.46 10.0 1.5 2.5 2 0 0 2 2 2 0 Putative transmembrane protein (PGPGW) Pyr_redox_2 PF07992.14 CAV18312.1 - 5.1e-47 160.5 0.7 6e-47 160.3 0.7 1.0 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 CAV18312.1 - 3.2e-20 72.6 0.1 6.6e-17 61.7 0.0 2.1 1 1 1 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 CAV18312.1 - 7.4e-18 64.9 3.8 1.5e-17 63.9 1.2 2.4 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 CAV18312.1 - 1.6e-07 30.7 3.8 0.0013 17.9 0.1 3.5 3 1 0 4 4 4 3 FAD binding domain GIDA PF01134.22 CAV18312.1 - 1.9e-05 23.9 1.9 0.082 12.0 0.1 3.5 4 0 0 4 4 4 2 Glucose inhibited division protein A HI0933_like PF03486.14 CAV18312.1 - 0.00019 20.3 0.5 0.8 8.3 0.1 4.2 4 1 1 5 5 5 1 HI0933-like protein FAD_oxidored PF12831.7 CAV18312.1 - 0.00048 19.6 1.5 0.00082 18.8 0.0 2.0 2 1 1 3 3 3 1 FAD dependent oxidoreductase NAD_binding_7 PF13241.6 CAV18312.1 - 0.009 16.4 0.0 0.24 11.9 0.1 2.2 2 0 0 2 2 2 1 Putative NAD(P)-binding DAO PF01266.24 CAV18312.1 - 0.014 15.0 0.9 9.5 5.7 0.1 3.5 3 1 1 4 4 4 0 FAD dependent oxidoreductase K_oxygenase PF13434.6 CAV18312.1 - 0.032 13.4 0.0 0.083 12.0 0.0 1.7 1 1 0 1 1 1 0 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_8 PF13450.6 CAV18312.1 - 0.041 14.1 0.0 0.14 12.4 0.0 1.9 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain Shikimate_DH PF01488.20 CAV18312.1 - 0.063 13.3 0.2 1.7 8.7 0.0 2.7 3 0 0 3 3 3 0 Shikimate / quinate 5-dehydrogenase FMO-like PF00743.19 CAV18312.1 - 0.083 11.3 0.0 0.12 10.8 0.0 1.2 1 0 0 1 1 1 0 Flavin-binding monooxygenase-like AlaDh_PNT_C PF01262.21 CAV18312.1 - 0.11 11.8 1.8 2.7 7.2 0.1 2.5 2 1 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain Trp_halogenase PF04820.14 CAV18312.1 - 0.14 10.9 0.3 1.9 7.2 0.1 2.1 2 0 0 2 2 2 0 Tryptophan halogenase HipA_C PF07804.12 CAV18314.1 - 9e-09 35.3 0.0 1.2e-08 34.9 0.0 1.2 1 0 0 1 1 1 1 HipA-like C-terminal domain Fam20C PF06702.12 CAV18314.1 - 0.00094 19.1 0.0 0.0016 18.3 0.0 1.4 1 0 0 1 1 1 1 Golgi casein kinase, C-terminal, Fam20 PI3_PI4_kinase PF00454.27 CAV18314.1 - 0.0012 18.7 0.0 0.002 18.0 0.0 1.6 1 1 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase HIRAN PF08797.11 CAV18315.1 - 0.0092 15.9 0.0 0.015 15.3 0.0 1.3 1 0 0 1 1 1 1 HIRAN domain BESS PF02944.20 CAV18315.1 - 0.13 12.1 0.7 0.22 11.4 0.7 1.4 1 0 0 1 1 1 0 BESS motif Pentapeptide PF00805.22 CAV18316.1 - 1.3e-33 114.2 58.6 1.5e-12 46.9 6.2 6.2 2 2 5 7 7 7 7 Pentapeptide repeats (8 copies) Pentapeptide_4 PF13599.6 CAV18316.1 - 2.6e-23 82.0 27.1 7.1e-12 45.3 3.5 4.4 2 1 2 4 4 4 3 Pentapeptide repeats (9 copies) Pentapeptide_3 PF13576.6 CAV18316.1 - 3.1e-17 62.5 33.9 2e-06 27.9 5.1 5.7 2 2 3 5 5 5 5 Pentapeptide repeats (9 copies) NACHT PF05729.12 CAV18316.1 - 6.6e-07 29.4 0.0 1.6e-06 28.1 0.0 1.6 1 0 0 1 1 1 1 NACHT domain AAA PF00004.29 CAV18316.1 - 4.2e-05 24.0 0.0 0.00011 22.6 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.6 CAV18316.1 - 4.7e-05 24.0 0.0 0.16 12.5 0.0 3.4 3 0 0 3 3 3 2 AAA domain AAA_14 PF13173.6 CAV18316.1 - 0.00074 19.6 0.1 0.021 14.8 0.0 3.1 3 0 0 3 3 3 1 AAA domain AAA_22 PF13401.6 CAV18316.1 - 0.0089 16.3 0.0 0.081 13.2 0.0 2.7 2 1 0 2 2 2 1 AAA domain CobU PF02283.16 CAV18316.1 - 0.02 14.4 1.0 0.75 9.3 0.0 3.2 4 0 0 4 4 4 0 Cobinamide kinase / cobinamide phosphate guanyltransferase AAA_33 PF13671.6 CAV18316.1 - 0.026 14.7 0.0 0.1 12.7 0.0 2.1 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 CAV18316.1 - 0.028 14.8 0.1 0.12 12.8 0.0 2.1 2 0 0 2 2 1 0 RNA helicase KTI12 PF08433.10 CAV18316.1 - 0.059 12.8 0.0 0.28 10.6 0.0 2.0 2 0 0 2 2 2 0 Chromatin associated protein KTI12 AAA_16 PF13191.6 CAV18316.1 - 0.084 13.3 0.0 0.6 10.5 0.0 2.4 2 0 0 2 2 2 0 AAA ATPase domain POTRA_TamA_1 PF17243.2 CAV18316.1 - 0.087 12.9 0.5 29 4.8 0.0 3.2 2 1 1 3 3 3 0 POTRA domain TamA domain 1 IstB_IS21 PF01695.17 CAV18316.1 - 0.089 12.5 0.0 0.4 10.4 0.0 2.1 2 0 0 2 2 1 0 IstB-like ATP binding protein DUF1871 PF08958.10 CAV18316.1 - 0.098 13.0 0.4 9.8 6.6 0.0 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF1871) FtsK_SpoIIIE PF01580.18 CAV18316.1 - 0.12 11.7 0.0 0.26 10.6 0.0 1.5 1 0 0 1 1 1 0 FtsK/SpoIIIE family DUF4957 PF16318.5 CAV18316.1 - 1.1 9.2 8.9 2.6 8.0 5.5 2.9 2 1 0 2 2 2 0 Domain of unknown function (DUF4957) DUF87 PF01935.17 CAV18316.1 - 2.9 7.9 6.1 0.46 10.5 0.1 2.8 3 1 0 3 3 3 0 Helicase HerA, central domain CfAFP PF05264.11 CAV18316.1 - 3.2 7.7 6.2 4.8 7.2 0.6 2.5 1 1 1 2 2 2 0 Choristoneura fumiferana antifreeze protein (CfAFP) 2OG-Fe_Oxy_2 PF10014.9 CAV18317.1 - 3.4e-54 183.6 0.2 3.9e-54 183.4 0.2 1.0 1 0 0 1 1 1 1 2OG-Fe dioxygenase Myosin-VI_CBD PF16521.5 CAV18317.1 - 0.028 14.4 0.0 0.049 13.6 0.0 1.4 1 0 0 1 1 1 0 Myosin VI cargo binding domain Aminotran_5 PF00266.19 CAV18318.1 - 1.5e-66 224.9 0.1 5.1e-66 223.1 0.1 1.7 1 1 0 1 1 1 1 Aminotransferase class-V Cys_Met_Meta_PP PF01053.20 CAV18318.1 - 1.5e-11 43.5 0.7 3.7e-11 42.2 0.4 1.4 1 1 1 2 2 2 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_1_2 PF00155.21 CAV18318.1 - 2.4e-10 40.2 0.0 3.5e-10 39.6 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II DegT_DnrJ_EryC1 PF01041.17 CAV18318.1 - 6.8e-09 35.5 0.3 9.7e-09 35.0 0.3 1.2 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Beta_elim_lyase PF01212.21 CAV18318.1 - 8.9e-05 21.9 0.1 0.00013 21.3 0.1 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase DJ-1_PfpI PF01965.24 CAV18319.1 - 9.4e-16 58.0 0.0 2.6e-15 56.6 0.0 1.7 1 1 0 1 1 1 1 DJ-1/PfpI family GATase_3 PF07685.14 CAV18319.1 - 0.0055 16.3 0.0 0.0084 15.7 0.0 1.3 1 0 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain ThiJ_like PF17124.5 CAV18319.1 - 0.1 12.3 0.0 0.25 11.0 0.0 1.4 1 1 0 1 1 1 0 ThiJ/PfpI family-like LysR_substrate PF03466.20 CAV18320.1 - 8.6e-38 129.8 0.0 3.5e-37 127.8 0.0 1.7 2 0 0 2 2 2 1 LysR substrate binding domain HTH_1 PF00126.27 CAV18320.1 - 5.3e-18 64.7 0.3 1e-17 63.8 0.3 1.5 1 0 0 1 1 1 1 Bacterial regulatory helix-turn-helix protein, lysR family HTH_28 PF13518.6 CAV18320.1 - 0.013 15.6 0.1 0.028 14.5 0.1 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_23 PF13384.6 CAV18320.1 - 0.042 13.7 0.0 0.13 12.1 0.0 1.8 2 0 0 2 2 2 0 Homeodomain-like domain HTH_29 PF13551.6 CAV18320.1 - 0.095 12.7 0.5 0.22 11.6 0.1 1.9 2 0 0 2 2 2 0 Winged helix-turn helix GGDEF PF00990.21 CAV18321.1 - 9.1e-37 126.3 0.0 2e-36 125.2 0.0 1.6 2 0 0 2 2 2 1 Diguanylate cyclase, GGDEF domain PAS_3 PF08447.12 CAV18321.1 - 6.8e-06 26.3 0.1 3.6e-05 24.0 0.1 2.1 2 0 0 2 2 2 1 PAS fold DUF2797 PF10977.8 CAV18322.1 - 1.2e-95 319.9 0.2 1.3e-95 319.7 0.2 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2797) GGDEF PF00990.21 CAV18323.1 - 1.1e-39 135.8 0.1 1.9e-39 135.0 0.1 1.4 1 0 0 1 1 1 1 Diguanylate cyclase, GGDEF domain DUF523 PF04463.12 CAV18323.1 - 0.17 11.9 0.1 0.37 10.8 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF523) GlpM PF06942.12 CAV18324.1 - 6.6e-49 164.8 10.5 7.6e-49 164.6 10.5 1.0 1 0 0 1 1 1 1 GlpM protein DUF3147 PF11345.8 CAV18324.1 - 0.013 15.9 7.3 0.017 15.5 7.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3147) Lambda_Bor PF06291.11 CAV18324.1 - 0.091 12.8 0.0 0.12 12.4 0.0 1.2 1 0 0 1 1 1 0 Bor protein Na_sulph_symp PF00939.19 CAV18325.1 - 7.1e-60 203.4 44.5 1e-59 202.9 44.5 1.2 1 0 0 1 1 1 1 Sodium:sulfate symporter transmembrane region CitMHS PF03600.16 CAV18325.1 - 1.8e-44 152.1 77.4 1.4e-35 122.9 43.2 2.2 1 1 1 2 2 2 2 Citrate transporter DUF1646 PF07854.12 CAV18325.1 - 0.0014 18.1 3.7 0.0014 18.1 3.7 3.3 2 1 1 3 3 3 2 Protein of unknown function (DUF1646) DUF3767 PF12597.8 CAV18325.1 - 0.4 10.5 2.2 4.6 7.1 0.2 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3767) Phage_ASH PF10554.9 CAV18326.1 - 0.025 14.9 0.6 0.025 14.9 0.6 1.9 2 0 0 2 2 2 0 Ash protein family DUF218 PF02698.17 CAV18327.1 - 3.7e-19 69.0 0.0 6.1e-19 68.3 0.0 1.3 1 0 0 1 1 1 1 DUF218 domain PT PF04886.12 CAV18327.1 - 2.3 7.8 14.7 0.6 9.7 9.3 2.2 1 1 1 2 2 2 0 PT repeat Malic_M PF03949.15 CAV18328.1 - 1e-104 349.4 0.1 1.4e-104 349.0 0.1 1.2 1 0 0 1 1 1 1 Malic enzyme, NAD binding domain malic PF00390.19 CAV18328.1 - 6e-78 260.8 0.0 8.7e-78 260.3 0.0 1.2 1 0 0 1 1 1 1 Malic enzyme, N-terminal domain Helicase_C PF00271.31 CAV18329.1 - 1.1e-14 54.8 0.5 3.5e-14 53.1 0.2 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 CAV18329.1 - 2.6e-07 30.6 0.0 8e-07 29.0 0.0 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase HA2 PF04408.23 CAV18329.1 - 1.1e-05 25.7 0.2 2.2e-05 24.7 0.2 1.5 1 0 0 1 1 1 1 Helicase associated domain (HA2) DUF1944 PF09175.10 CAV18329.1 - 0.049 13.5 0.0 0.13 12.1 0.0 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF1944) SAICAR_synt PF01259.18 CAV18331.1 - 6.9e-47 160.2 0.0 8.6e-46 156.6 0.0 2.0 1 1 0 1 1 1 1 SAICAR synthetase SulA PF03846.14 CAV18332.1 - 6.5e-07 29.3 0.1 9.4e-07 28.8 0.1 1.3 1 0 0 1 1 1 1 Cell division inhibitor SulA Pox_A51 PF04948.13 CAV18332.1 - 0.016 14.1 0.5 0.021 13.7 0.5 1.1 1 0 0 1 1 1 0 Poxvirus A51 protein UPF0167 PF03691.14 CAV18332.1 - 0.04 13.7 0.1 0.052 13.4 0.1 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0167) DUF3239 PF11580.8 CAV18332.1 - 0.046 14.0 0.0 0.097 13.0 0.0 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3239) GSG-1 PF07803.11 CAV18332.1 - 0.062 13.2 0.5 0.1 12.5 0.3 1.5 1 1 0 1 1 1 0 GSG1-like protein Sel1 PF08238.12 CAV18334.1 - 4.4e-17 62.1 3.5 1.3e-08 35.2 0.2 3.1 3 0 0 3 3 3 2 Sel1 repeat DnaJ PF00226.31 CAV18334.1 - 0.0046 17.1 0.5 0.02 15.0 0.0 2.2 2 0 0 2 2 2 1 DnaJ domain TPR_17 PF13431.6 CAV18334.1 - 0.027 14.8 0.3 3.8 8.1 0.0 3.3 2 1 1 3 3 3 0 Tetratricopeptide repeat FliP PF00813.20 CAV18334.1 - 0.079 12.8 0.8 0.12 12.3 0.1 1.6 2 0 0 2 2 2 0 FliP family ABC2_membrane_3 PF12698.7 CAV18334.1 - 0.26 10.4 5.1 0.53 9.3 5.0 1.7 1 1 0 1 1 1 0 ABC-2 family transporter protein TPR_11 PF13414.6 CAV18334.1 - 0.36 10.6 7.0 6.3 6.6 0.7 4.0 4 0 0 4 4 4 0 TPR repeat OmpA PF00691.20 CAV18335.1 - 7.1e-22 77.6 0.0 1.7e-21 76.4 0.0 1.6 2 0 0 2 2 2 1 OmpA family Gly-zipper_Omp PF13488.6 CAV18335.1 - 1.5e-12 47.3 12.7 1.5e-12 47.3 12.7 1.8 2 0 0 2 2 2 1 Glycine zipper Gly-zipper_YMGG PF13441.6 CAV18335.1 - 1.6e-11 43.8 18.9 3.3e-11 42.7 18.9 1.6 1 0 0 1 1 1 1 YMGG-like Gly-zipper Rick_17kDa_Anti PF05433.15 CAV18335.1 - 3.5e-07 30.0 16.9 3.5e-07 30.0 16.9 2.0 2 0 0 2 2 2 1 Glycine zipper 2TM domain LPAM_1 PF08139.12 CAV18335.1 - 0.00026 21.3 1.8 0.0008 19.8 1.8 1.9 1 0 0 1 1 1 1 Prokaryotic membrane lipoprotein lipid attachment site Gly-zipper_OmpA PF13436.6 CAV18335.1 - 0.00036 20.2 23.2 0.00089 19.0 6.2 2.4 2 0 0 2 2 2 2 Glycine-zipper domain Phage_fiber_2 PF03406.13 CAV18335.1 - 0.02 14.4 0.8 0.02 14.4 0.8 2.2 2 0 0 2 2 2 0 Phage tail fibre repeat TraT PF05818.12 CAV18335.1 - 0.14 11.8 5.4 0.24 11.1 5.4 1.4 1 0 0 1 1 1 0 Enterobacterial TraT complement resistance protein DUF2786 PF10979.8 CAV18336.1 - 8.4e-11 41.6 3.0 8.4e-11 41.6 3.0 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF2786) Linker_histone PF00538.19 CAV18336.1 - 0.014 15.8 2.3 0.082 13.3 0.1 2.4 2 0 0 2 2 2 0 linker histone H1 and H5 family PdaC PF13739.6 CAV18336.1 - 0.13 13.2 0.6 0.13 13.2 0.6 2.0 2 0 0 2 2 2 0 Deacetylase PdaC Aida_N PF08910.10 CAV18336.1 - 0.17 12.3 1.2 0.82 10.1 0.1 2.2 2 0 0 2 2 2 0 Aida N-terminus DUF3334 PF11813.8 CAV18337.1 - 3.3e-116 386.8 2.8 3.7e-116 386.6 2.8 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3334) CheX PF13690.6 CAV18337.1 - 8.4e-09 35.5 0.5 3e-08 33.7 0.1 2.0 2 0 0 2 2 2 1 Chemotaxis phosphatase CheX Myosin_TH1 PF06017.13 CAV18337.1 - 0.0054 16.4 0.1 0.017 14.8 0.1 1.8 1 1 0 1 1 1 1 Unconventional myosin tail, actin- and lipid-binding CheC PF04509.12 CAV18337.1 - 0.025 14.5 0.0 0.053 13.4 0.0 1.6 1 0 0 1 1 1 0 CheC-like family SWIRM-assoc_3 PF16498.5 CAV18337.1 - 0.12 12.7 0.1 0.48 10.7 0.0 2.1 2 0 0 2 2 2 0 SWIRM-associated domain at the C-terminal FAD-oxidase_C PF02913.19 CAV18338.1 - 7.2e-64 215.8 0.1 1e-63 215.3 0.1 1.3 1 0 0 1 1 1 1 FAD linked oxidases, C-terminal domain FAD_binding_4 PF01565.23 CAV18338.1 - 6.6e-35 119.9 0.1 1.2e-34 119.0 0.1 1.5 1 0 0 1 1 1 1 FAD binding domain Fer4_8 PF13183.6 CAV18338.1 - 3.3e-12 46.7 2.8 9.4e-12 45.2 2.8 1.8 1 1 0 1 1 1 1 4Fe-4S dicluster domain Fer4_17 PF13534.6 CAV18338.1 - 0.0012 19.3 5.9 0.02 15.4 5.9 2.5 1 1 0 1 1 1 1 4Fe-4S dicluster domain BBE PF08031.12 CAV18338.1 - 0.0017 18.4 0.0 0.0042 17.2 0.0 1.6 1 0 0 1 1 1 1 Berberine and berberine like Fer4_20 PF14691.6 CAV18338.1 - 0.0041 16.9 0.4 0.0086 15.8 0.4 1.5 1 0 0 1 1 1 1 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster Fer4_10 PF13237.6 CAV18338.1 - 0.018 15.2 1.8 0.049 13.8 1.8 1.7 1 1 0 1 1 1 0 4Fe-4S dicluster domain Fer4_18 PF13746.6 CAV18338.1 - 0.06 13.5 0.4 0.06 13.5 0.4 1.8 2 0 0 2 2 2 0 4Fe-4S dicluster domain Fer4_4 PF12800.7 CAV18338.1 - 0.06 13.9 0.7 0.21 12.1 0.7 1.9 1 0 0 1 1 1 0 4Fe-4S binding domain Fer4_7 PF12838.7 CAV18338.1 - 0.2 12.3 5.8 0.75 10.4 5.7 2.1 1 1 0 1 1 1 0 4Fe-4S dicluster domain Fer4_21 PF14697.6 CAV18338.1 - 2.3 8.4 5.4 0.3 11.2 0.5 2.1 3 0 0 3 3 3 0 4Fe-4S dicluster domain PEMT PF04191.13 CAV18339.1 - 4e-12 46.5 2.2 4e-12 46.5 2.2 1.4 2 0 0 2 2 2 1 Phospholipid methyltransferase ICMT PF04140.14 CAV18339.1 - 0.00023 21.5 0.4 0.00031 21.1 0.1 1.5 2 0 0 2 2 2 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family UPF0182 PF03699.13 CAV18339.1 - 0.04 12.1 1.3 0.69 8.0 0.2 2.0 1 1 0 2 2 2 0 Uncharacterised protein family (UPF0182) DUF1295 PF06966.12 CAV18339.1 - 0.056 13.0 4.2 0.095 12.2 4.2 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1295) PSII PF00421.19 CAV18339.1 - 0.11 11.2 0.5 0.12 11.0 0.5 1.0 1 0 0 1 1 1 0 Photosystem II protein DUF4199 PF13858.6 CAV18339.1 - 0.2 12.1 7.9 1.3 9.3 0.7 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF4199) SieB PF14163.6 CAV18339.1 - 0.76 9.3 4.2 1.3 8.5 0.1 2.4 2 1 0 2 2 2 0 Super-infection exclusion protein B YfhO PF09586.10 CAV18339.1 - 1.1 7.4 8.4 1.4 7.0 8.4 1.1 1 0 0 1 1 1 0 Bacterial membrane protein YfhO DUF3581 PF12119.8 CAV18340.1 - 1.8e-98 328.2 1.5 2.1e-98 328.0 1.5 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3581) Lyase_aromatic PF00221.19 CAV18342.1 - 1.7e-186 620.4 5.8 2e-186 620.2 5.8 1.0 1 0 0 1 1 1 1 Aromatic amino acid lyase Urocanase_C PF17392.2 CAV18343.1 - 7.1e-92 306.2 0.0 1.2e-91 305.5 0.0 1.4 1 0 0 1 1 1 1 Urocanase C-terminal domain Urocanase PF01175.18 CAV18343.1 - 2.7e-84 282.0 0.4 3.8e-84 281.5 0.4 1.2 1 0 0 1 1 1 1 Urocanase Rossmann-like domain Urocanase_N PF17391.2 CAV18343.1 - 1.7e-62 208.8 0.0 3e-62 208.0 0.0 1.4 1 0 0 1 1 1 1 Urocanase N-terminal domain Arginase PF00491.21 CAV18344.1 - 5.6e-63 213.1 0.1 7.3e-63 212.7 0.1 1.1 1 0 0 1 1 1 1 Arginase family Amidohydro_3 PF07969.11 CAV18345.1 - 4.9e-19 69.2 0.8 4.1e-12 46.3 0.2 2.5 1 1 1 2 2 2 2 Amidohydrolase family Amidohydro_1 PF01979.20 CAV18345.1 - 1.6e-17 63.8 0.7 5.8e-17 62.0 0.7 1.7 1 1 0 1 1 1 1 Amidohydrolase family UTRA PF07702.13 CAV18346.1 - 6.9e-33 113.5 0.0 9.5e-33 113.0 0.0 1.2 1 0 0 1 1 1 1 UTRA domain GntR PF00392.21 CAV18346.1 - 7.4e-17 60.8 0.0 1.4e-16 59.9 0.0 1.5 1 0 0 1 1 1 1 Bacterial regulatory proteins, gntR family HTH_11 PF08279.12 CAV18346.1 - 0.00024 21.0 0.1 0.00061 19.7 0.1 1.6 1 0 0 1 1 1 1 HTH domain HTH_41 PF14502.6 CAV18346.1 - 0.0024 17.5 0.0 0.0058 16.3 0.0 1.7 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_DeoR PF08220.12 CAV18346.1 - 0.0029 17.3 0.5 0.013 15.2 0.1 2.0 2 0 0 2 2 2 1 DeoR-like helix-turn-helix domain HTH_24 PF13412.6 CAV18346.1 - 0.0087 15.6 0.0 0.017 14.6 0.0 1.5 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding DUF977 PF06163.11 CAV18346.1 - 0.045 13.7 0.0 0.081 12.9 0.0 1.5 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF977) MarR PF01047.22 CAV18346.1 - 0.046 13.6 0.1 0.11 12.4 0.1 1.5 1 0 0 1 1 1 0 MarR family Imm-NTF2 PF15655.6 CAV18346.1 - 0.14 12.4 0.0 0.27 11.5 0.0 1.4 1 0 0 1 1 1 0 NTF2 fold immunity protein Spo0M PF07070.11 CAV18347.1 - 5.3e-59 199.3 0.1 6.1e-59 199.1 0.1 1.0 1 0 0 1 1 1 1 SpoOM protein HIP1_clath_bdg PF16515.5 CAV18348.1 - 0.13 12.9 0.0 0.14 12.8 0.0 1.3 1 0 0 1 1 1 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Poxvirus_B22R_C PF13168.6 CAV18350.1 - 0.049 13.1 0.0 0.067 12.7 0.0 1.2 1 0 0 1 1 1 0 Poxvirus B22R protein C-terminal DUF3732 PF12532.8 CAV18351.1 - 1.3e-53 181.4 0.0 5e-53 179.5 0.0 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF3732) AAA_23 PF13476.6 CAV18351.1 - 8.4e-05 23.2 1.7 8.4e-05 23.2 1.7 2.8 1 1 1 2 2 2 1 AAA domain AAA_29 PF13555.6 CAV18351.1 - 0.0041 16.8 0.0 0.009 15.7 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain SMC_N PF02463.19 CAV18351.1 - 0.0044 16.5 1.2 0.012 15.1 0.1 2.2 3 0 0 3 3 3 1 RecF/RecN/SMC N terminal domain NTPase_1 PF03266.15 CAV18351.1 - 0.096 12.6 0.0 0.31 11.0 0.0 1.8 1 0 0 1 1 1 0 NTPase ABC_tran PF00005.27 CAV18351.1 - 1.5 9.4 8.5 0.65 10.5 2.6 3.1 2 2 1 3 3 3 0 ABC transporter Tex_N PF09371.10 CAV18351.1 - 2.5 7.7 7.9 6.5 6.4 0.6 3.2 2 1 1 3 3 3 0 Tex-like protein N-terminal domain Med9 PF07544.13 CAV18351.1 - 3.3 7.9 15.1 6.9 6.8 0.6 3.7 3 0 0 3 3 3 0 RNA polymerase II transcription mediator complex subunit 9 Phage_AlpA PF05930.12 CAV18353.1 - 0.00044 20.0 0.0 0.00056 19.7 0.0 1.2 1 0 0 1 1 1 1 Prophage CP4-57 regulatory protein (AlpA) HTH_Tnp_1_2 PF13022.6 CAV18353.1 - 0.0084 16.3 0.0 0.0094 16.1 0.0 1.2 1 0 0 1 1 1 1 Helix-turn-helix of insertion element transposase HTH_17 PF12728.7 CAV18353.1 - 0.031 14.5 0.1 0.041 14.1 0.1 1.4 1 1 0 1 1 1 0 Helix-turn-helix domain HTH_23 PF13384.6 CAV18353.1 - 0.047 13.5 0.0 0.058 13.2 0.0 1.2 1 0 0 1 1 1 0 Homeodomain-like domain tRNA-synt_2b PF00587.25 CAV18357.1 - 4.2e-50 170.2 0.0 8.9e-50 169.1 0.0 1.5 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.20 CAV18357.1 - 1.5e-22 79.5 0.4 5.3e-22 77.8 0.4 2.0 1 0 0 1 1 1 1 Anticodon binding domain tRNA_SAD PF07973.14 CAV18357.1 - 1.8e-13 50.4 0.0 3.5e-13 49.4 0.0 1.5 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain TGS PF02824.21 CAV18357.1 - 8.9e-12 44.9 0.2 8.7e-11 41.7 0.0 2.6 3 0 0 3 3 3 1 TGS domain Imm74 PF15603.6 CAV18357.1 - 0.038 14.2 0.0 0.12 12.6 0.0 1.9 1 0 0 1 1 1 0 Immunity protein 74 DUF5638 PF18688.1 CAV18357.1 - 0.12 12.7 0.2 0.37 11.1 0.2 1.8 1 0 0 1 1 1 0 Family of unknown function (DUF5638) IF3_C PF00707.22 CAV18359.1 - 1.5e-36 124.2 0.3 2.5e-36 123.5 0.3 1.4 1 0 0 1 1 1 1 Translation initiation factor IF-3, C-terminal domain IF3_N PF05198.16 CAV18359.1 - 1.7e-23 82.6 0.1 3.4e-23 81.7 0.1 1.5 1 0 0 1 1 1 1 Translation initiation factor IF-3, N-terminal domain Ribosomal_L35p PF01632.19 CAV18360.1 - 1.9e-21 76.3 6.7 2.1e-21 76.2 6.7 1.0 1 0 0 1 1 1 1 Ribosomal protein L35 Ribosomal_L20 PF00453.18 CAV18362.1 - 4.3e-49 165.1 9.6 4.8e-49 164.9 9.7 1.0 1 0 0 1 1 1 1 Ribosomal protein L20 SMC_ScpA PF02616.14 CAV18362.1 - 0.0033 17.4 0.3 0.0042 17.0 0.3 1.2 1 0 0 1 1 1 1 Segregation and condensation protein ScpA ASCH PF04266.14 CAV18364.1 - 2.3e-15 57.1 0.0 2.4e-15 57.0 0.0 1.0 1 0 0 1 1 1 1 ASCH domain DUF3850 PF12961.7 CAV18364.1 - 0.02 15.0 0.0 0.038 14.0 0.0 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF3850) CVNH PF08881.10 CAV18365.1 - 0.13 13.0 0.0 0.18 12.5 0.0 1.3 1 1 0 1 1 1 0 CVNH domain LRR_8 PF13855.6 CAV18367.1 - 1.7e-18 66.1 20.6 2.6e-08 33.5 1.0 4.5 1 1 4 5 5 5 4 Leucine rich repeat Pkinase PF00069.25 CAV18367.1 - 2.9e-16 59.6 0.0 4.1e-16 59.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CAV18367.1 - 1.5e-15 57.2 0.0 2.2e-15 56.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase LRR_4 PF12799.7 CAV18367.1 - 6.1e-13 48.7 12.3 1.8e-05 25.0 2.6 4.8 3 1 0 4 4 4 2 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 CAV18367.1 - 7.8e-07 28.8 1.3 0.0036 16.8 0.1 2.4 1 1 1 2 2 2 2 Leucine-rich repeat Kinase-like PF14531.6 CAV18367.1 - 4.7e-05 22.9 0.0 6.9e-05 22.3 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 CAV18367.1 - 8.8e-05 22.0 0.1 0.00013 21.4 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RsmF_methylt_CI PF17126.5 CAV18367.1 - 0.0069 16.4 0.2 6.5 6.9 0.0 2.7 2 0 0 2 2 2 2 RsmF rRNA methyltransferase first C-terminal domain RIO1 PF01163.22 CAV18367.1 - 0.02 14.5 0.0 0.05 13.2 0.0 1.7 1 0 0 1 1 1 0 RIO1 family APH PF01636.23 CAV18367.1 - 0.045 13.7 0.0 0.076 12.9 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family MIase PF02426.16 CAV18367.1 - 0.051 13.7 0.0 0.17 12.1 0.0 1.9 1 0 0 1 1 1 0 Muconolactone delta-isomerase DUF2164 PF09932.9 CAV18367.1 - 0.067 13.2 0.2 5.6 7.1 0.0 2.6 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2164) THF_DHG_CYH PF00763.23 CAV18367.1 - 0.11 12.8 0.1 42 4.5 0.0 3.2 4 0 0 4 4 3 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain ABC_tran PF00005.27 CAV18369.1 - 1.4e-37 129.3 9.2 9.7e-19 68.2 0.1 3.5 3 1 0 3 3 2 2 ABC transporter AAA_21 PF13304.6 CAV18369.1 - 4.9e-16 59.4 15.0 0.00089 19.2 0.1 4.4 2 2 1 4 4 4 4 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 CAV18369.1 - 3.6e-15 56.0 9.7 1.3e-06 28.0 0.0 4.7 4 1 1 5 5 5 4 RecF/RecN/SMC N terminal domain RsgA_GTPase PF03193.16 CAV18369.1 - 2.4e-08 34.0 2.4 0.0015 18.4 0.1 2.9 2 1 0 2 2 2 2 RsgA GTPase AAA_29 PF13555.6 CAV18369.1 - 2.8e-07 30.2 1.8 0.0029 17.3 0.1 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_22 PF13401.6 CAV18369.1 - 5.3e-07 30.0 6.9 0.0002 21.6 0.0 3.9 3 1 0 3 3 3 2 AAA domain AAA_23 PF13476.6 CAV18369.1 - 1.4e-05 25.7 0.8 0.0098 16.4 0.0 3.9 3 1 0 3 3 2 2 AAA domain AAA_16 PF13191.6 CAV18369.1 - 8.5e-05 23.0 4.7 0.0053 17.2 0.0 3.2 2 1 1 3 3 3 1 AAA ATPase domain ABC_tran_Xtn PF12848.7 CAV18369.1 - 9.4e-05 22.4 4.6 9.4e-05 22.4 4.6 2.0 2 0 0 2 2 1 1 ABC transporter MMR_HSR1 PF01926.23 CAV18369.1 - 9.6e-05 22.4 0.1 0.63 10.2 0.0 2.9 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_15 PF13175.6 CAV18369.1 - 0.00034 20.4 17.6 0.4 10.3 0.1 4.2 3 1 0 3 3 3 1 AAA ATPase domain SbcCD_C PF13558.6 CAV18369.1 - 0.00061 20.0 1.7 0.34 11.2 0.1 4.3 3 2 0 3 3 3 1 Putative exonuclease SbcCD, C subunit AAA_30 PF13604.6 CAV18369.1 - 0.0016 18.2 0.3 0.96 9.1 0.0 3.2 3 1 0 3 3 3 1 AAA domain ATP-synt_ab PF00006.25 CAV18369.1 - 0.0019 17.9 0.1 0.0078 15.9 0.0 2.0 2 1 0 2 2 2 1 ATP synthase alpha/beta family, nucleotide-binding domain NACHT PF05729.12 CAV18369.1 - 0.0028 17.6 1.4 0.25 11.2 0.0 3.0 3 0 0 3 3 3 1 NACHT domain AAA_25 PF13481.6 CAV18369.1 - 0.0038 16.8 0.2 1.6 8.3 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_28 PF13521.6 CAV18369.1 - 0.0044 17.3 0.0 0.0044 17.3 0.0 2.6 3 0 0 3 3 3 1 AAA domain AAA PF00004.29 CAV18369.1 - 0.0056 17.1 2.2 0.15 12.4 0.0 3.3 3 1 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) RNA_helicase PF00910.22 CAV18369.1 - 0.0099 16.3 0.4 0.53 10.7 0.0 2.6 2 0 0 2 2 2 1 RNA helicase NB-ARC PF00931.22 CAV18369.1 - 0.014 14.6 0.1 0.6 9.2 0.0 2.4 2 0 0 2 2 2 0 NB-ARC domain Zeta_toxin PF06414.12 CAV18369.1 - 0.069 12.4 3.4 2.6 7.3 0.0 2.8 3 0 0 3 3 3 0 Zeta toxin AAA_14 PF13173.6 CAV18369.1 - 0.075 13.1 0.4 0.84 9.7 0.0 2.9 3 0 0 3 3 3 0 AAA domain DUF815 PF05673.13 CAV18369.1 - 0.078 12.1 0.1 0.078 12.1 0.1 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF815) AAA_33 PF13671.6 CAV18369.1 - 0.11 12.6 4.9 0.38 10.9 0.0 3.0 3 0 0 3 3 3 0 AAA domain AAA_7 PF12775.7 CAV18369.1 - 0.12 11.8 0.4 2.7 7.5 0.0 2.5 2 1 0 2 2 2 0 P-loop containing dynein motor region MukB PF04310.12 CAV18369.1 - 0.14 11.9 4.4 1.3 8.8 0.1 2.9 3 1 1 4 4 3 0 MukB N-terminal FeoB_N PF02421.18 CAV18369.1 - 0.22 11.0 0.4 4.3 6.9 0.0 2.4 2 0 0 2 2 2 0 Ferrous iron transport protein B Ploopntkinase3 PF18751.1 CAV18369.1 - 0.25 11.2 4.0 8.5 6.2 0.1 3.1 3 0 0 3 3 3 0 P-loop Nucleotide Kinase3 Viral_helicase1 PF01443.18 CAV18369.1 - 0.3 10.8 0.0 0.3 10.8 0.0 2.7 3 1 0 3 3 2 0 Viral (Superfamily 1) RNA helicase PduV-EutP PF10662.9 CAV18369.1 - 0.47 10.2 2.3 1.3 8.8 0.1 2.8 4 0 0 4 4 3 0 Ethanolamine utilisation - propanediol utilisation DUF4407 PF14362.6 CAV18369.1 - 0.67 9.3 10.8 1.3 8.3 10.4 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) cobW PF02492.19 CAV18369.1 - 0.76 9.3 2.6 14 5.2 0.1 2.6 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_18 PF13238.6 CAV18369.1 - 0.89 10.1 0.0 0.89 10.1 0.0 3.1 3 1 1 4 4 3 0 AAA domain TetR_N PF00440.23 CAV18371.1 - 3.9e-16 58.6 0.1 7.1e-16 57.7 0.1 1.4 1 0 0 1 1 1 1 Bacterial regulatory proteins, tetR family TetR_C_10 PF16295.5 CAV18371.1 - 0.0012 19.1 0.3 0.0019 18.5 0.3 1.3 1 0 0 1 1 1 1 Tetracyclin repressor-like, C-terminal domain HTH_Tnp_1_2 PF13022.6 CAV18371.1 - 0.027 14.6 0.1 0.055 13.6 0.1 1.6 1 0 0 1 1 1 0 Helix-turn-helix of insertion element transposase Aldedh PF00171.22 CAV18373.1 - 1.9e-92 310.2 0.0 2.3e-92 309.9 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family ORC3_N PF07034.11 CAV18373.1 - 0.0011 18.1 0.0 0.0018 17.4 0.0 1.2 1 0 0 1 1 1 1 Origin recognition complex (ORC) subunit 3 N-terminus Orn_Arg_deC_N PF02784.16 CAV18374.1 - 2.2e-51 174.6 0.1 3.8e-51 173.9 0.1 1.3 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, pyridoxal binding domain Arg_decarb_HB PF17810.1 CAV18374.1 - 1.3e-21 76.6 0.7 6.3e-21 74.4 0.7 2.3 1 0 0 1 1 1 1 Arginine decarboxylase helical bundle domain Arg_decarbox_C PF17944.1 CAV18374.1 - 8.2e-13 48.7 4.3 8.9e-13 48.6 1.5 2.6 2 0 0 2 2 2 1 Arginine decarboxylase C-terminal helical extension Arginase PF00491.21 CAV18375.1 - 3.3e-88 295.8 0.2 4.1e-88 295.5 0.2 1.0 1 0 0 1 1 1 1 Arginase family Cadherin_5 PF17892.1 CAV18376.1 - 1e-21 76.7 14.5 2.7e-14 52.9 4.8 17.2 18 3 2 20 20 20 3 Cadherin-like domain Big_9 PF17963.1 CAV18376.1 - 3.2e-17 63.0 19.5 4.3e-11 43.4 6.0 34.7 24 14 7 32 32 32 5 Bacterial Ig domain HemolysinCabind PF00353.19 CAV18376.1 - 9.8e-13 47.8 46.7 7.6e-09 35.4 18.8 3.7 2 1 1 3 3 3 2 RTX calcium-binding nonapeptide repeat (4 copies) Cadherin_4 PF17803.1 CAV18376.1 - 9.1e-12 45.4 17.9 5.9e-08 33.2 4.0 31.3 30 7 2 32 32 32 5 Bacterial cadherin-like domain HU-CCDC81_bac_2 PF18175.1 CAV18376.1 - 0.018 14.9 5.1 7.6 6.5 0.1 5.5 7 0 0 7 7 7 0 CCDC81-like prokaryotic HU domain 2 DUF1081 PF06448.11 CAV18376.1 - 0.031 14.7 0.1 4.9e+02 1.1 0.0 6.0 7 0 0 7 7 7 0 Domain of Unknown Function (DUF1081) Y_Y_Y PF07495.13 CAV18376.1 - 0.91 9.5 6.7 4 7.5 0.0 5.5 7 0 0 7 7 7 0 Y_Y_Y domain SSF PF00474.17 CAV18377.1 - 4.9e-41 140.9 34.7 7.1e-41 140.4 34.7 1.3 1 0 0 1 1 1 1 Sodium:solute symporter family DUF1118 PF06549.12 CAV18377.1 - 0.12 12.7 1.7 0.52 10.6 1.7 2.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1118) DUF4748 PF15932.5 CAV18377.1 - 4.2 7.2 5.1 1.9 8.3 1.9 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4748) Aldolase PF01081.19 CAV18378.1 - 5.2e-70 234.9 0.2 5.9e-70 234.7 0.2 1.0 1 0 0 1 1 1 1 KDPG and KHG aldolase IMPDH PF00478.25 CAV18378.1 - 0.012 14.6 0.0 0.014 14.4 0.0 1.1 1 0 0 1 1 1 0 IMP dehydrogenase / GMP reductase domain KDGP_aldolase PF07071.11 CAV18378.1 - 0.034 13.9 0.0 0.086 12.6 0.0 1.6 1 1 0 1 1 1 0 KDGP aldolase PfkB PF00294.24 CAV18379.1 - 1.5e-60 205.1 0.0 1.7e-60 204.9 0.0 1.0 1 0 0 1 1 1 1 pfkB family carbohydrate kinase DUF2634 PF10934.8 CAV18379.1 - 0.034 14.3 0.1 0.064 13.4 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2634) Cupin_2 PF07883.11 CAV18380.1 - 8e-11 41.5 0.6 9.4e-11 41.3 0.6 1.1 1 0 0 1 1 1 1 Cupin domain AraC_binding PF02311.19 CAV18380.1 - 0.00035 20.5 0.2 0.00043 20.2 0.2 1.1 1 0 0 1 1 1 1 AraC-like ligand binding domain Cupin_1 PF00190.22 CAV18380.1 - 0.004 16.8 0.0 0.0056 16.3 0.0 1.2 1 0 0 1 1 1 1 Cupin Ectoine_synth PF06339.12 CAV18380.1 - 0.054 13.7 0.1 0.15 12.2 0.0 1.5 1 1 1 2 2 2 0 Ectoine synthase Cupin_3 PF05899.12 CAV18380.1 - 0.058 13.1 0.1 0.08 12.6 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF861) Hepar_II_III PF07940.13 CAV18382.1 - 4.3e-23 82.2 0.6 7.2e-23 81.4 0.6 1.3 1 0 0 1 1 1 1 Heparinase II/III-like protein Alginate_lyase PF05426.12 CAV18382.1 - 8.2e-16 58.4 0.0 1.7e-15 57.4 0.0 1.4 1 0 0 1 1 1 1 Alginate lyase BAT PF15915.5 CAV18382.1 - 0.071 13.0 0.2 0.13 12.1 0.2 1.3 1 0 0 1 1 1 0 GAF and HTH_10 associated domain Hepar_II_III PF07940.13 CAV18383.1 - 1.4e-20 74.0 2.2 2.1e-20 73.4 2.2 1.2 1 0 0 1 1 1 1 Heparinase II/III-like protein Alginate_lyase PF05426.12 CAV18383.1 - 8.7e-14 51.7 0.1 2.2e-13 50.4 0.0 1.7 2 0 0 2 2 2 1 Alginate lyase Hepar_II_III_N PF16889.5 CAV18383.1 - 0.041 13.1 0.1 0.38 10.0 0.0 2.2 2 0 0 2 2 2 0 Heparinase II/III N-terminus NAD_binding_2 PF03446.15 CAV18384.1 - 2.3e-38 131.8 3.5 3.7e-38 131.2 3.5 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.6 CAV18384.1 - 1.4e-18 67.2 0.4 1.4e-18 67.2 0.4 1.8 2 0 0 2 2 2 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase F420_oxidored PF03807.17 CAV18384.1 - 7.8e-06 26.4 0.9 1.6e-05 25.4 0.3 1.9 2 0 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent 2-Hacid_dh_C PF02826.19 CAV18384.1 - 1.5e-05 24.4 0.6 1.5e-05 24.4 0.6 1.5 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 3HCDH_N PF02737.18 CAV18384.1 - 0.00011 22.1 1.5 0.00015 21.7 0.5 1.7 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain UDPG_MGDP_dh PF00984.19 CAV18384.1 - 0.0032 17.6 0.1 0.0087 16.2 0.1 1.7 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, central domain Epimerase PF01370.21 CAV18384.1 - 0.039 13.4 0.1 2.7 7.4 0.0 2.1 2 0 0 2 2 2 0 NAD dependent epimerase/dehydratase family Sacchrp_dh_NADP PF03435.18 CAV18384.1 - 0.044 14.0 0.1 0.87 9.8 0.0 2.7 2 1 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain Shikimate_DH PF01488.20 CAV18384.1 - 0.077 13.1 0.5 0.2 11.7 0.1 1.9 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase TrkA_N PF02254.18 CAV18384.1 - 0.084 13.1 0.0 0.21 11.9 0.0 1.7 1 0 0 1 1 1 0 TrkA-N domain MatE PF01554.18 CAV18385.1 - 1.1e-30 106.4 33.7 1.1e-23 83.7 13.4 2.6 2 1 1 3 3 3 2 MatE Polysacc_synt_C PF14667.6 CAV18385.1 - 3.1e-06 27.3 18.9 3.1e-06 27.3 18.9 4.4 2 2 2 4 4 4 2 Polysaccharide biosynthesis C-terminal domain FCD PF07729.12 CAV18387.1 - 2.1e-20 73.4 0.2 4e-20 72.5 0.0 1.5 2 0 0 2 2 2 1 FCD domain GntR PF00392.21 CAV18387.1 - 3.8e-18 64.9 0.1 6.3e-18 64.2 0.1 1.4 1 0 0 1 1 1 1 Bacterial regulatory proteins, gntR family HTH_11 PF08279.12 CAV18387.1 - 0.0018 18.2 0.0 0.0039 17.1 0.0 1.6 1 0 0 1 1 1 1 HTH domain MarR_2 PF12802.7 CAV18387.1 - 0.036 13.9 0.0 0.083 12.8 0.0 1.6 1 0 0 1 1 1 0 MarR family Fe_dep_repress PF01325.19 CAV18387.1 - 0.2 11.9 0.2 0.75 10.0 0.1 2.0 2 0 0 2 2 2 0 Iron dependent repressor, N-terminal DNA binding domain FCD PF07729.12 CAV18388.1 - 2.8e-21 76.2 0.1 5.2e-21 75.4 0.1 1.4 1 0 0 1 1 1 1 FCD domain GntR PF00392.21 CAV18388.1 - 4.5e-17 61.5 0.2 8.2e-17 60.6 0.2 1.5 1 0 0 1 1 1 1 Bacterial regulatory proteins, gntR family HTH_11 PF08279.12 CAV18388.1 - 0.0036 17.2 0.0 0.0076 16.2 0.0 1.5 1 0 0 1 1 1 1 HTH domain MarR_2 PF12802.7 CAV18388.1 - 0.015 15.2 0.0 0.03 14.2 0.0 1.4 1 0 0 1 1 1 0 MarR family PaaX PF07848.12 CAV18388.1 - 0.046 13.9 0.1 0.11 12.8 0.0 1.6 1 1 0 1 1 1 0 PaaX-like protein HTH_24 PF13412.6 CAV18388.1 - 0.077 12.6 0.0 0.15 11.6 0.0 1.5 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding DUF294 PF03445.13 CAV18389.1 - 1.3e-42 144.8 0.0 2.2e-42 144.1 0.0 1.4 1 0 0 1 1 1 1 Putative nucleotidyltransferase DUF294 DUF294_C PF10335.9 CAV18389.1 - 2.2e-40 137.8 0.0 4.1e-40 136.9 0.0 1.4 1 0 0 1 1 1 1 Putative nucleotidyltransferase substrate binding domain CBS PF00571.28 CAV18389.1 - 8.4e-15 55.0 2.3 1.7e-10 41.1 0.2 2.7 2 0 0 2 2 2 2 CBS domain cNMP_binding PF00027.29 CAV18389.1 - 3.9e-07 30.0 0.1 4.7e-06 26.6 0.0 2.5 2 0 0 2 2 2 1 Cyclic nucleotide-binding domain DUF512 PF04459.12 CAV18389.1 - 0.14 11.4 0.0 0.34 10.2 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF512) RNase_T PF00929.24 CAV18390.1 - 2e-19 70.7 0.1 3e-19 70.2 0.1 1.3 1 0 0 1 1 1 1 Exonuclease RNase_H_2 PF13482.6 CAV18390.1 - 0.074 13.0 0.0 0.13 12.2 0.0 1.8 1 1 0 1 1 1 0 RNase_H superfamily DUF5051 PF16473.5 CAV18390.1 - 0.09 12.8 0.3 0.36 10.8 0.3 1.9 1 1 0 1 1 1 0 3' exoribonuclease, RNase T-like CAF1 PF04857.20 CAV18390.1 - 0.1 11.7 0.1 1.3 8.1 0.0 2.2 2 1 0 2 2 2 0 CAF1 family ribonuclease KdgM PF06178.13 CAV18391.1 - 2.9e-36 125.2 10.6 4.1e-35 121.4 10.6 1.9 1 1 0 1 1 1 1 Oligogalacturonate-specific porin protein (KdgM) Porin_4 PF13609.6 CAV18391.1 - 0.0013 18.5 8.3 0.0053 16.6 5.4 2.2 1 1 1 2 2 2 1 Gram-negative porin LptD PF04453.14 CAV18391.1 - 0.017 14.4 8.7 0.68 9.1 4.0 2.3 1 1 1 2 2 2 0 LPS transport system D MORN_2 PF07661.13 CAV18393.1 - 1.4e-18 64.7 11.5 0.00044 20.2 0.1 6.3 6 0 0 6 6 6 5 MORN repeat variant Porin_7 PF16956.5 CAV18393.1 - 0.0039 16.9 1.8 0.21 11.2 0.2 2.3 1 1 1 2 2 2 2 Putative general bacterial porin MORN PF02493.20 CAV18393.1 - 0.18 11.8 7.3 13 6.0 0.2 4.9 5 1 0 5 5 5 0 MORN repeat SSF PF00474.17 CAV18395.1 - 3.2e-39 135.0 30.8 5.3e-39 134.2 30.8 1.4 1 0 0 1 1 1 1 Sodium:solute symporter family RseC_MucC PF04246.12 CAV18395.1 - 0.12 12.4 0.1 0.12 12.4 0.1 4.6 4 2 1 5 5 5 0 Positive regulator of sigma(E), RseC/MucC DUF4748 PF15932.5 CAV18395.1 - 2.9 7.7 6.1 0.74 9.6 2.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4748) PMSR PF01625.21 CAV18398.1 - 3.1e-40 137.8 0.2 4.4e-40 137.4 0.2 1.2 1 0 0 1 1 1 1 Peptide methionine sulfoxide reductase MMR_HSR1 PF01926.23 CAV18399.1 - 3.2e-08 33.6 0.0 6.3e-08 32.7 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase DUF697 PF05128.12 CAV18399.1 - 1.2e-06 28.3 0.0 2e-06 27.6 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF697) AIG1 PF04548.16 CAV18399.1 - 1.8e-05 24.2 0.1 2.6e-05 23.7 0.1 1.4 1 0 0 1 1 1 1 AIG1 family IIGP PF05049.13 CAV18399.1 - 2.7e-05 23.4 0.0 7.1e-05 22.0 0.0 1.5 1 1 0 1 1 1 1 Interferon-inducible GTPase (IIGP) EcsC PF12787.7 CAV18399.1 - 0.0015 18.3 1.9 0.38 10.4 1.9 3.4 1 1 0 1 1 1 1 EcsC protein family DUF4112 PF13430.6 CAV18399.1 - 0.0022 18.2 0.4 0.2 12.0 0.0 2.9 1 1 2 3 3 3 1 Domain of unknown function (DUF4112) ABC_tran PF00005.27 CAV18399.1 - 0.0025 18.3 0.4 0.0081 16.7 0.4 2.1 1 1 0 1 1 1 1 ABC transporter Dynamin_N PF00350.23 CAV18399.1 - 0.0039 17.3 1.5 0.026 14.6 0.2 2.4 2 1 0 2 2 2 1 Dynamin family RsgA_GTPase PF03193.16 CAV18399.1 - 0.0042 17.0 0.3 0.044 13.7 0.0 2.2 2 0 0 2 2 2 1 RsgA GTPase FeoB_N PF02421.18 CAV18399.1 - 0.024 14.2 0.1 0.054 13.0 0.0 1.7 2 0 0 2 2 2 0 Ferrous iron transport protein B Z1 PF10593.9 CAV18399.1 - 0.071 12.6 0.3 0.12 11.8 0.3 1.3 1 0 0 1 1 1 0 Z1 domain AAA_29 PF13555.6 CAV18399.1 - 0.082 12.7 0.0 0.18 11.6 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain MMR_HSR1 PF01926.23 CAV18400.1 - 7.1e-13 48.7 0.1 1.5e-12 47.6 0.1 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_N PF00350.23 CAV18400.1 - 2.3e-10 40.8 2.8 5.7e-05 23.2 0.3 3.0 2 1 1 3 3 3 2 Dynamin family RsgA_GTPase PF03193.16 CAV18400.1 - 0.00014 21.8 0.1 0.00043 20.2 0.0 1.8 1 1 1 2 2 2 1 RsgA GTPase AIG1 PF04548.16 CAV18400.1 - 0.00027 20.3 0.1 0.00057 19.3 0.1 1.6 1 0 0 1 1 1 1 AIG1 family Roc PF08477.13 CAV18400.1 - 0.0011 19.2 0.1 0.0025 18.0 0.1 1.6 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase IIGP PF05049.13 CAV18400.1 - 0.0025 16.9 0.0 0.005 15.9 0.0 1.4 1 0 0 1 1 1 1 Interferon-inducible GTPase (IIGP) FeoB_N PF02421.18 CAV18400.1 - 0.0036 16.8 0.1 0.0089 15.6 0.1 1.7 1 0 0 1 1 1 1 Ferrous iron transport protein B AAA_29 PF13555.6 CAV18400.1 - 0.0051 16.5 0.0 0.013 15.2 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain DUF815 PF05673.13 CAV18400.1 - 0.0083 15.3 0.0 0.015 14.4 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) Zeta_toxin PF06414.12 CAV18400.1 - 0.0096 15.2 0.0 0.03 13.6 0.0 1.8 1 0 0 1 1 1 1 Zeta toxin SRPRB PF09439.10 CAV18400.1 - 0.015 14.8 0.1 0.039 13.4 0.0 1.7 2 0 0 2 2 2 0 Signal recognition particle receptor beta subunit G-alpha PF00503.20 CAV18400.1 - 0.029 13.6 0.0 0.055 12.6 0.0 1.5 1 0 0 1 1 1 0 G-protein alpha subunit TsaE PF02367.17 CAV18400.1 - 0.029 14.4 0.0 0.071 13.1 0.0 1.6 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_16 PF13191.6 CAV18400.1 - 0.031 14.7 0.0 0.1 13.0 0.0 2.0 2 0 0 2 2 2 0 AAA ATPase domain AAA_23 PF13476.6 CAV18400.1 - 0.055 14.0 0.1 0.12 12.9 0.1 1.7 1 1 0 1 1 1 0 AAA domain AAA_21 PF13304.6 CAV18400.1 - 0.082 12.7 0.7 0.46 10.2 0.0 2.3 2 0 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system T2SSE PF00437.20 CAV18400.1 - 0.083 11.9 0.0 0.14 11.1 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein ABC_tran PF00005.27 CAV18400.1 - 0.085 13.4 0.0 0.22 12.0 0.0 1.7 1 0 0 1 1 1 0 ABC transporter AAA_28 PF13521.6 CAV18400.1 - 0.087 13.1 0.0 0.18 12.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain Beta_elim_lyase PF01212.21 CAV18401.1 - 3.7e-85 285.8 0.2 4.4e-85 285.5 0.2 1.1 1 0 0 1 1 1 1 Beta-eliminating lyase Aminotran_1_2 PF00155.21 CAV18401.1 - 0.0023 17.2 0.0 0.0053 16.0 0.0 1.6 1 0 0 1 1 1 1 Aminotransferase class I and II SepSecS PF05889.13 CAV18401.1 - 0.0038 16.0 0.1 0.0065 15.2 0.1 1.3 1 0 0 1 1 1 1 O-phosphoseryl-tRNA(Sec) selenium transferase, SepSecS LysR_substrate PF03466.20 CAV18402.1 - 3.1e-11 43.1 0.0 3.7e-11 42.8 0.0 1.1 1 0 0 1 1 1 1 LysR substrate binding domain HTH_1 PF00126.27 CAV18402.1 - 3e-06 27.1 0.0 5.3e-06 26.3 0.0 1.4 1 0 0 1 1 1 1 Bacterial regulatory helix-turn-helix protein, lysR family Oxidored_q2 PF00420.24 CAV18403.1 - 0.09 12.4 0.0 0.09 12.4 0.0 1.1 1 0 0 1 1 1 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L Dabb PF07876.12 CAV18405.1 - 2.5e-31 108.2 0.0 2.7e-31 108.0 0.0 1.0 1 0 0 1 1 1 1 Stress responsive A/B Barrel Domain T6SS_VasE PF05936.12 CAV18405.1 - 0.036 12.8 0.0 0.049 12.3 0.0 1.1 1 0 0 1 1 1 0 Bacterial Type VI secretion, VC_A0110, EvfL, ImpJ, VasE DUF2605 PF10792.9 CAV18405.1 - 0.082 12.8 0.1 9 6.3 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2605) DUF3103 PF11301.8 CAV18406.1 - 1.5e-174 579.9 4.4 1.7e-174 579.7 4.4 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3103) DUF3679 PF12438.8 CAV18406.1 - 0.003 17.2 0.0 0.0064 16.2 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF3679) Peptidase_M4_C PF02868.15 CAV18407.1 - 1.1e-36 126.3 1.7 1.5e-36 125.8 1.0 1.7 2 0 0 2 2 2 1 Thermolysin metallopeptidase, alpha-helical domain Peptidase_M4 PF01447.18 CAV18407.1 - 1.7e-36 125.9 4.0 1.7e-36 125.9 4.0 2.6 3 0 0 3 3 3 1 Thermolysin metallopeptidase, catalytic domain FTP PF07504.13 CAV18407.1 - 2.4e-11 43.3 0.4 2.5e-10 40.0 0.2 2.4 2 0 0 2 2 2 1 Fungalysin/Thermolysin Propeptide Motif PepSY PF03413.19 CAV18407.1 - 6.4e-11 42.6 0.0 1.6e-10 41.4 0.0 1.7 1 0 0 1 1 1 1 Peptidase propeptide and YPEB domain PPC PF04151.15 CAV18407.1 - 8e-11 42.9 0.2 8e-11 42.9 0.2 2.7 2 0 0 2 2 2 1 Bacterial pre-peptidase C-terminal domain DUF5315 PF17242.2 CAV18408.1 - 0.17 11.8 0.0 0.28 11.0 0.0 1.3 1 0 0 1 1 1 0 Disordered region of unknown function (DUF5315) Acetyltransf_7 PF13508.7 CAV18411.1 - 3.6e-08 33.7 0.5 5e-08 33.3 0.5 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 CAV18411.1 - 6.7e-07 29.3 0.1 8.1e-07 29.0 0.1 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 CAV18411.1 - 4e-05 23.8 0.1 4.8e-05 23.6 0.1 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family DUF2204 PF09970.9 CAV18412.1 - 0.0035 17.0 0.4 0.036 13.7 0.1 2.0 2 0 0 2 2 2 1 Nucleotidyl transferase of unknown function (DUF2204) DUF2007 PF09413.10 CAV18412.1 - 0.023 14.8 0.0 0.047 13.9 0.0 1.5 1 0 0 1 1 1 0 Putative prokaryotic signal transducing protein YjbR PF04237.13 CAV18413.1 - 3.1e-12 46.9 0.0 3.6e-12 46.7 0.0 1.1 1 0 0 1 1 1 1 YjbR Kelch_1 PF01344.25 CAV18413.1 - 0.0042 16.6 0.0 0.0069 16.0 0.0 1.3 1 0 0 1 1 1 1 Kelch motif Na_sulph_symp PF00939.19 CAV18414.1 - 1.5e-50 172.7 41.0 2e-50 172.3 41.0 1.1 1 0 0 1 1 1 1 Sodium:sulfate symporter transmembrane region CitMHS PF03600.16 CAV18414.1 - 5.7e-33 114.4 35.8 5.7e-33 114.4 35.8 2.2 1 1 1 2 2 2 2 Citrate transporter DctM PF06808.12 CAV18414.1 - 0.42 9.4 46.0 0.65 8.8 16.1 2.3 2 1 0 2 2 2 0 Tripartite ATP-independent periplasmic transporter, DctM component Gate PF07670.14 CAV18414.1 - 1.2 9.4 24.6 0.09 13.1 4.1 4.6 4 2 0 4 4 4 0 Nucleoside recognition HATPase_c PF02518.26 CAV18415.1 - 1.4e-17 64.2 0.2 2.8e-17 63.2 0.2 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase cNMP_binding PF00027.29 CAV18415.1 - 4.2e-09 36.4 0.0 1.1e-08 35.0 0.0 1.7 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain HATPase_c_5 PF14501.6 CAV18415.1 - 1.6e-07 31.2 0.0 3.9e-07 29.9 0.0 1.6 1 0 0 1 1 1 1 GHKL domain HisKA PF00512.25 CAV18415.1 - 0.007 16.4 0.0 0.034 14.2 0.0 2.2 1 1 0 1 1 1 1 His Kinase A (phospho-acceptor) domain TarS_C1 PF18674.1 CAV18415.1 - 0.019 14.9 0.0 0.039 13.9 0.0 1.5 1 0 0 1 1 1 0 TarS beta-glycosyltransferase C-terminal domain 1 Response_reg PF00072.24 CAV18417.1 - 6.8e-14 52.0 0.1 8.4e-14 51.7 0.1 1.1 1 0 0 1 1 1 1 Response regulator receiver domain Peptidase_C23 PF05379.11 CAV18417.1 - 0.0065 16.6 0.0 0.011 15.9 0.0 1.4 1 0 0 1 1 1 1 Carlavirus endopeptidase UPF0270 PF06794.12 CAV18417.1 - 0.074 13.1 0.0 0.16 12.1 0.0 1.5 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0270) OGFr_N PF04664.13 CAV18418.1 - 9.8e-16 57.9 0.1 1.2e-15 57.6 0.1 1.1 1 0 0 1 1 1 1 Opioid growth factor receptor (OGFr) conserved region CSD PF00313.22 CAV18421.1 - 2.2e-13 49.9 0.1 2.8e-13 49.5 0.1 1.2 1 0 0 1 1 1 1 'Cold-shock' DNA-binding domain Excalibur PF05901.11 CAV18421.1 - 3.3e-09 37.2 1.2 7.2e-09 36.1 1.2 1.6 1 0 0 1 1 1 1 Excalibur calcium-binding domain OB_RNB PF08206.11 CAV18421.1 - 0.0049 16.5 0.2 0.012 15.3 0.2 1.7 1 1 0 1 1 1 1 Ribonuclease B OB domain RsgA_N PF16745.5 CAV18421.1 - 0.019 14.7 0.0 0.035 13.9 0.0 1.4 1 0 0 1 1 1 0 RsgA N-terminal domain DUF4538 PF15061.6 CAV18421.1 - 0.04 13.7 0.0 0.059 13.1 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4538) Acetyltransf_4 PF13420.7 CAV18422.1 - 6.7e-23 81.5 0.1 7.4e-23 81.4 0.1 1.0 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 CAV18422.1 - 2.6e-13 50.3 0.0 3.4e-13 49.9 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_3 PF13302.7 CAV18422.1 - 1.4e-09 38.7 0.0 1.8e-09 38.4 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 CAV18422.1 - 4.4e-07 30.2 0.1 6.8e-07 29.6 0.1 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 CAV18422.1 - 6.9e-07 29.2 0.2 1e-06 28.7 0.2 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 CAV18422.1 - 2.4e-06 27.4 0.0 3.6e-06 26.9 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein GNAT_acetyltran PF12746.7 CAV18422.1 - 0.0077 15.8 0.1 0.011 15.3 0.1 1.3 1 0 0 1 1 1 1 GNAT acetyltransferase Acetyltransf_8 PF13523.6 CAV18422.1 - 0.014 15.1 0.0 0.022 14.5 0.0 1.4 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain TPR_2 PF07719.17 CAV18423.1 - 9.8e-13 47.2 6.7 0.0019 18.2 0.0 5.1 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_5 PF12688.7 CAV18423.1 - 3e-12 46.8 0.4 5.5e-12 46.0 0.1 1.5 1 1 1 2 2 2 1 Tetratrico peptide repeat TPR_6 PF13174.6 CAV18423.1 - 4.7e-10 39.4 10.5 0.00015 22.2 0.2 4.8 4 1 0 4 4 4 2 Tetratricopeptide repeat TPR_7 PF13176.6 CAV18423.1 - 1.7e-09 37.0 8.2 0.00059 19.7 0.0 4.7 4 1 1 5 5 5 3 Tetratricopeptide repeat TPR_1 PF00515.28 CAV18423.1 - 2.5e-08 33.4 6.8 0.0082 15.9 0.1 4.8 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_19 PF14559.6 CAV18423.1 - 1.2e-07 32.1 6.0 4.5e-06 27.1 0.2 2.8 2 1 0 2 2 2 1 Tetratricopeptide repeat MIT PF04212.18 CAV18423.1 - 8.1e-07 29.0 4.7 0.95 9.6 0.1 4.3 4 0 0 4 4 4 3 MIT (microtubule interacting and transport) domain TPR_8 PF13181.6 CAV18423.1 - 4.5e-06 26.4 9.9 0.2 12.0 0.1 4.8 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_12 PF13424.6 CAV18423.1 - 4.7e-06 26.8 12.8 0.024 14.9 0.1 4.2 3 2 1 4 4 4 2 Tetratricopeptide repeat TPR_16 PF13432.6 CAV18423.1 - 9.9e-06 26.1 6.7 0.0026 18.4 0.1 3.9 2 2 2 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.6 CAV18423.1 - 1.5e-05 25.4 2.9 0.21 12.5 0.0 4.3 2 2 3 5 5 5 1 Tetratricopeptide repeat ANAPC3 PF12895.7 CAV18423.1 - 1.9e-05 24.8 5.3 5.6e-05 23.3 2.3 2.8 2 1 1 3 3 3 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_20 PF14561.6 CAV18423.1 - 0.0057 17.0 0.5 0.38 11.1 0.0 2.6 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_10 PF13374.6 CAV18423.1 - 0.0076 16.1 6.8 0.28 11.1 0.1 4.8 5 1 1 6 6 6 1 Tetratricopeptide repeat TPR_15 PF13429.6 CAV18423.1 - 0.0088 15.3 3.2 0.046 12.9 0.0 2.4 1 1 2 3 3 3 1 Tetratricopeptide repeat DUF2225 PF09986.9 CAV18423.1 - 0.017 14.9 0.0 0.039 13.7 0.0 1.7 1 1 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2225) TPR_17 PF13431.6 CAV18423.1 - 0.17 12.3 5.3 5.6 7.6 0.3 4.1 4 1 0 4 4 4 0 Tetratricopeptide repeat TPR_11 PF13414.6 CAV18423.1 - 8 6.2 10.2 1 9.1 0.2 3.8 3 2 2 5 5 5 0 TPR repeat Meth_synt_2 PF01717.18 CAV18424.1 - 4.2e-38 131.4 0.0 9.4e-38 130.3 0.0 1.5 1 1 0 1 1 1 1 Cobalamin-independent synthase, Catalytic domain Meth_synt_1 PF08267.12 CAV18424.1 - 6.7e-05 22.5 0.1 0.0022 17.6 0.0 2.5 2 1 0 2 2 2 1 Cobalamin-independent synthase, N-terminal domain CNP1 PF08750.11 CAV18424.1 - 0.00083 19.3 0.0 0.0015 18.5 0.0 1.4 1 0 0 1 1 1 1 CNP1-like family URO-D PF01208.17 CAV18424.1 - 0.044 12.9 0.0 0.069 12.3 0.0 1.3 1 0 0 1 1 1 0 Uroporphyrinogen decarboxylase (URO-D) DUF1852 PF08908.11 CAV18425.1 - 8.3e-182 603.4 4.6 9.4e-182 603.2 4.6 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1852) TauE PF01925.19 CAV18426.1 - 2e-51 174.9 34.8 2.4e-51 174.6 34.8 1.0 1 0 0 1 1 1 1 Sulfite exporter TauE/SafE DUF2723 PF11028.8 CAV18426.1 - 0.0066 16.4 1.9 0.0066 16.4 1.9 2.1 1 1 1 2 2 2 1 Protein of unknown function (DUF2723) TssN PF17555.2 CAV18426.1 - 0.52 9.7 10.1 0.52 9.7 1.2 2.2 2 0 0 2 2 2 0 Type VI secretion system, TssN Flagellin_D3 PF08884.11 CAV18427.1 - 0.082 13.3 0.1 0.11 12.9 0.1 1.2 1 0 0 1 1 1 0 Flagellin D3 domain DUF2905 PF11146.8 CAV18427.1 - 7.2 6.9 7.8 0.91 9.8 0.8 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2905) YdjM PF04307.14 CAV18428.1 - 4.3e-26 91.2 7.4 6.4e-26 90.7 7.4 1.2 1 0 0 1 1 1 1 LexA-binding, inner membrane-associated putative hydrolase DUF981 PF06168.11 CAV18428.1 - 0.11 12.4 5.3 0.039 13.9 2.6 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF981) RseC_MucC PF04246.12 CAV18428.1 - 8.4 6.4 5.6 36 4.3 0.1 2.8 3 0 0 3 3 3 0 Positive regulator of sigma(E), RseC/MucC DHDPS PF00701.22 CAV18429.1 - 0.05 12.3 0.0 0.052 12.3 0.0 1.1 1 0 0 1 1 1 0 Dihydrodipicolinate synthetase family Peptidase_M32 PF02074.15 CAV18431.1 - 5.4e-170 566.3 0.2 6.2e-170 566.2 0.2 1.0 1 0 0 1 1 1 1 Carboxypeptidase Taq (M32) metallopeptidase LysE PF01810.18 CAV18432.1 - 5.1e-31 107.6 9.5 6e-31 107.4 9.5 1.0 1 0 0 1 1 1 1 LysE type translocator TerC PF03741.16 CAV18432.1 - 0.0075 16.0 4.1 0.02 14.6 0.3 2.2 2 0 0 2 2 2 2 Integral membrane protein TerC family Na_Ala_symp PF01235.17 CAV18433.1 - 1.9e-138 462.0 36.3 2.5e-138 461.7 36.3 1.0 1 0 0 1 1 1 1 Sodium:alanine symporter family Borrelia_P83 PF05262.11 CAV18434.1 - 0.0041 15.7 16.9 0.0048 15.5 16.9 1.1 1 0 0 1 1 1 1 Borrelia P83/100 protein MctB PF11382.8 CAV18434.1 - 0.072 12.8 0.2 0.072 12.8 0.2 2.7 1 1 2 3 3 3 0 Copper transport outer membrane protein, MctB DUF3584 PF12128.8 CAV18434.1 - 0.074 10.6 27.2 0.094 10.2 27.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Glt_symporter PF03616.14 CAV18434.1 - 0.23 10.1 1.4 0.25 10.0 0.1 1.6 1 1 1 2 2 2 0 Sodium/glutamate symporter DUF4179 PF13786.6 CAV18434.1 - 0.25 11.9 1.4 0.65 10.5 1.4 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4179) FUSC PF04632.12 CAV18434.1 - 0.27 9.7 5.2 0.33 9.5 5.2 1.3 1 0 0 1 1 1 0 Fusaric acid resistance protein family FapA PF03961.13 CAV18434.1 - 0.56 8.7 21.1 0.14 10.8 11.3 2.1 1 1 2 3 3 3 0 Flagellar Assembly Protein A GAS PF13851.6 CAV18434.1 - 0.68 9.3 33.7 2.6 7.3 26.9 2.6 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding LMBR1 PF04791.16 CAV18434.1 - 0.93 8.3 7.8 1.1 8.0 7.8 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein APG6_N PF17675.1 CAV18434.1 - 1.4 9.5 34.8 4.2 7.9 7.9 2.5 1 1 1 2 2 2 0 Apg6 coiled-coil region DUF1043 PF06295.12 CAV18434.1 - 2.4 8.2 23.5 3.6 7.6 1.1 2.9 1 1 2 3 3 3 0 Protein of unknown function (DUF1043) DOR PF14839.6 CAV18434.1 - 2.4 8.0 11.3 3.8 7.4 11.3 1.4 1 0 0 1 1 1 0 DOR family Lebercilin PF15619.6 CAV18434.1 - 3.2 7.4 34.2 0.45 10.2 29.3 1.8 2 0 0 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease Spc24 PF08286.11 CAV18434.1 - 3.5 7.9 25.0 1.4 9.2 9.2 3.5 3 1 0 3 3 3 0 Spc24 subunit of Ndc80 Wzz PF02706.15 CAV18434.1 - 6.3 7.2 9.5 30 5.0 7.5 2.4 1 1 1 2 2 2 0 Chain length determinant protein Peptidase_S46 PF10459.9 CAV18434.1 - 6.7 5.2 17.7 7.9 5.0 17.7 1.0 1 0 0 1 1 1 0 Peptidase S46 bZIP_1 PF00170.21 CAV18434.1 - 7.8 6.7 19.8 7 6.8 1.0 3.4 3 0 0 3 3 3 0 bZIP transcription factor KxDL PF10241.9 CAV18434.1 - 8.4 6.8 24.7 3.3 8.1 13.3 3.4 2 1 1 3 3 3 0 Uncharacterized conserved protein Na_Ala_symp PF01235.17 CAV18436.1 - 1.5e-124 416.3 30.3 2.3e-124 415.7 30.3 1.2 1 0 0 1 1 1 1 Sodium:alanine symporter family ABC2_membrane_3 PF12698.7 CAV18437.1 - 1.1e-40 139.8 17.2 1.3e-40 139.6 17.2 1.0 1 0 0 1 1 1 1 ABC-2 family transporter protein ABC2_membrane PF01061.24 CAV18437.1 - 2e-10 40.5 23.5 2.4e-09 36.9 19.6 2.3 2 1 0 2 2 2 2 ABC-2 type transporter ABC2_membrane_3 PF12698.7 CAV18438.1 - 1.9e-46 158.8 25.4 2.3e-46 158.5 25.4 1.1 1 0 0 1 1 1 1 ABC-2 family transporter protein ABC2_membrane PF01061.24 CAV18438.1 - 0.002 17.6 23.1 0.002 17.6 23.1 2.1 2 1 0 2 2 2 1 ABC-2 type transporter TMEM154 PF15102.6 CAV18438.1 - 8.5 6.3 6.2 19 5.1 0.1 2.6 3 0 0 3 3 3 0 TMEM154 protein family HlyD_D23 PF16576.5 CAV18439.1 - 6.1e-13 48.5 6.3 6.2e-11 41.9 6.3 2.2 1 1 0 1 1 1 1 Barrel-sandwich domain of CusB or HlyD membrane-fusion Biotin_lipoyl_2 PF13533.6 CAV18439.1 - 1.1e-12 47.6 0.2 1e-10 41.2 0.1 2.9 2 0 0 2 2 2 1 Biotin-lipoyl like HlyD_3 PF13437.6 CAV18439.1 - 9.1e-11 42.4 0.0 7.8e-06 26.6 0.0 2.4 2 0 0 2 2 2 2 HlyD family secretion protein Biotin_lipoyl PF00364.22 CAV18439.1 - 3.5e-06 26.7 0.1 0.0024 17.7 0.0 2.4 2 0 0 2 2 2 2 Biotin-requiring enzyme SIX1_SD PF16878.5 CAV18439.1 - 0.0083 16.6 1.6 0.015 15.8 1.6 1.4 1 0 0 1 1 1 1 Transcriptional regulator, SIX1, N-terminal SD domain RnfC_N PF13375.6 CAV18439.1 - 0.011 15.7 0.1 3.1 7.8 0.0 2.4 2 0 0 2 2 2 0 RnfC Barrel sandwich hybrid domain OEP PF02321.18 CAV18440.1 - 1e-49 168.9 22.8 2.5e-26 92.6 6.1 2.1 2 0 0 2 2 2 2 Outer membrane efflux protein sCache_3_2 PF17203.4 CAV18442.1 - 2.4e-18 66.6 0.0 1.2e-17 64.4 0.0 2.0 2 0 0 2 2 2 1 Single cache domain 3 HATPase_c PF02518.26 CAV18442.1 - 1.2e-13 51.5 0.0 2.7e-13 50.4 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_5 PF14501.6 CAV18442.1 - 4.4e-10 39.4 0.0 9e-10 38.4 0.0 1.5 1 0 0 1 1 1 1 GHKL domain SPOB_a PF14689.6 CAV18442.1 - 4.5e-09 35.9 2.4 6.2e-09 35.4 1.3 1.8 2 0 0 2 2 2 1 Sensor_kinase_SpoOB-type, alpha-helical domain HATPase_c_2 PF13581.6 CAV18442.1 - 0.00016 21.6 0.0 0.0003 20.7 0.0 1.3 1 0 0 1 1 1 1 Histidine kinase-like ATPase domain PAS PF00989.25 CAV18442.1 - 0.00064 19.7 0.1 0.0037 17.3 0.0 2.2 2 0 0 2 2 2 1 PAS fold Cache_3-Cache_2 PF17201.4 CAV18442.1 - 0.0029 16.9 0.3 0.88 8.8 0.1 2.8 2 1 1 3 3 3 2 Cache 3/Cache 2 fusion domain PAS_9 PF13426.7 CAV18442.1 - 0.018 15.3 0.0 0.052 13.8 0.0 1.9 1 0 0 1 1 1 0 PAS domain UPF0014 PF03649.13 CAV18442.1 - 0.13 11.6 0.5 1.9 7.8 0.1 2.6 3 0 0 3 3 3 0 Uncharacterised protein family (UPF0014) Response_reg PF00072.24 CAV18443.1 - 2.5e-21 76.0 0.4 6.5e-21 74.6 0.2 1.7 2 0 0 2 2 2 1 Response regulator receiver domain CitT PF12431.8 CAV18443.1 - 8.2e-08 32.4 0.9 1.5e-07 31.6 0.1 1.9 2 0 0 2 2 2 1 Transcriptional regulator HTH_11 PF08279.12 CAV18443.1 - 0.0049 16.8 0.2 0.013 15.5 0.1 1.8 2 0 0 2 2 2 1 HTH domain DUF977 PF06163.11 CAV18443.1 - 0.052 13.5 0.1 0.11 12.4 0.0 1.6 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF977) KIAA1430 PF13879.6 CAV18443.1 - 0.077 13.8 0.0 0.12 13.2 0.0 1.3 1 0 0 1 1 1 0 KIAA1430 homologue G6PD_C PF02781.16 CAV18444.1 - 6.6e-117 389.8 0.0 1.1e-116 389.1 0.0 1.4 2 0 0 2 2 2 1 Glucose-6-phosphate dehydrogenase, C-terminal domain G6PD_N PF00479.22 CAV18444.1 - 2.6e-65 220.3 0.2 4.9e-65 219.5 0.2 1.4 1 0 0 1 1 1 1 Glucose-6-phosphate dehydrogenase, NAD binding domain Glucosamine_iso PF01182.20 CAV18445.1 - 3.3e-60 203.8 0.0 3.9e-60 203.5 0.0 1.0 1 0 0 1 1 1 1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase 6PGD PF00393.19 CAV18446.1 - 3.6e-126 420.4 0.0 4.3e-126 420.1 0.0 1.1 1 0 0 1 1 1 1 6-phosphogluconate dehydrogenase, C-terminal domain NAD_binding_2 PF03446.15 CAV18446.1 - 2.1e-51 174.2 0.0 3.2e-51 173.6 0.0 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase 2-Hacid_dh_C PF02826.19 CAV18446.1 - 0.0092 15.3 0.1 0.017 14.5 0.1 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain F420_oxidored PF03807.17 CAV18446.1 - 0.042 14.4 0.1 0.11 13.1 0.1 1.8 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent Shikimate_DH PF01488.20 CAV18446.1 - 0.056 13.5 0.1 0.11 12.6 0.1 1.5 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase NAD_binding_11 PF14833.6 CAV18446.1 - 0.15 12.3 0.2 0.52 10.6 0.1 2.0 2 0 0 2 2 2 0 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase HD PF01966.22 CAV18447.1 - 2.8e-17 63.1 1.4 5.6e-17 62.1 1.4 1.5 1 0 0 1 1 1 1 HD domain HD_5 PF13487.6 CAV18447.1 - 1.6e-13 50.7 0.0 4.9e-13 49.1 0.0 1.9 1 0 0 1 1 1 1 HD domain VF530 PF09905.9 CAV18448.1 - 8.6e-32 109.1 0.1 1.2e-31 108.6 0.1 1.2 1 0 0 1 1 1 1 DNA-binding protein VF530 Hydantoinase_B PF02538.14 CAV18448.1 - 0.17 10.2 0.0 0.18 10.2 0.0 1.1 1 0 0 1 1 1 0 Hydantoinase B/oxoprolinase DUF5337 PF17272.2 CAV18449.1 - 0.023 14.5 0.7 0.026 14.4 0.7 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5337) Cadherin_C_2 PF16492.5 CAV18449.1 - 0.06 14.1 0.5 0.06 14.1 0.5 1.7 1 1 1 2 2 2 0 Cadherin cytoplasmic C-terminal TauE PF01925.19 CAV18450.1 - 1.9e-36 125.9 32.2 2.4e-36 125.6 32.2 1.0 1 0 0 1 1 1 1 Sulfite exporter TauE/SafE SPC25 PF06703.11 CAV18450.1 - 0.056 13.2 4.4 0.17 11.7 1.3 2.3 2 0 0 2 2 2 0 Microsomal signal peptidase 25 kDa subunit (SPC25) DUF4181 PF13789.6 CAV18450.1 - 0.2 11.9 4.0 0.22 11.8 0.0 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF4181) TssN PF17555.2 CAV18450.1 - 0.43 9.9 10.3 0.55 9.6 7.6 2.2 1 1 1 2 2 2 0 Type VI secretion system, TssN DUF2556 PF10831.8 CAV18450.1 - 0.64 10.0 2.1 0.86 9.6 0.0 2.2 3 0 0 3 3 3 0 Protein of unknown function (DUF2556) DUF373 PF04123.13 CAV18450.1 - 1.7 8.0 8.1 0.37 10.2 1.6 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF373) TctA PF01970.16 CAV18451.1 - 2.2e-140 468.0 43.6 3.1e-140 467.5 43.6 1.2 1 0 0 1 1 1 1 Tripartite tricarboxylate transporter TctA family TctB PF07331.11 CAV18452.1 - 6.7e-15 55.6 12.6 9.2e-15 55.1 12.6 1.1 1 0 0 1 1 1 1 Tripartite tricarboxylate transporter TctB family CDP-OH_P_transf PF01066.21 CAV18452.1 - 5.2 7.9 9.4 28 5.6 6.0 2.9 2 1 0 2 2 2 0 CDP-alcohol phosphatidyltransferase TctC PF03401.14 CAV18453.1 - 1.9e-27 96.0 0.0 2.3e-27 95.7 0.0 1.0 1 0 0 1 1 1 1 Tripartite tricarboxylate transporter family receptor Phosphonate-bd PF12974.7 CAV18453.1 - 0.015 14.9 0.1 0.022 14.4 0.1 1.2 1 0 0 1 1 1 0 ABC transporter, phosphonate, periplasmic substrate-binding protein Gal11_ABD1 PF18535.1 CAV18454.1 - 0.13 12.3 0.1 0.19 11.8 0.1 1.3 1 0 0 1 1 1 0 Gal11 activator-binding domain (ABD1) Response_reg PF00072.24 CAV18455.1 - 4.3e-39 133.1 7.0 1.5e-23 83.1 2.2 3.0 2 0 0 2 2 2 2 Response regulator receiver domain HATPase_c PF02518.26 CAV18455.1 - 1.4e-31 109.3 0.5 4.7e-31 107.6 0.5 1.9 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 CAV18455.1 - 4.3e-17 61.9 0.0 3.1e-16 59.2 0.0 2.7 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain Hpt PF01627.23 CAV18455.1 - 4.4e-07 30.1 0.5 4.3e-06 26.9 0.0 2.9 2 0 0 2 2 2 1 Hpt domain HATPase_c_3 PF13589.6 CAV18455.1 - 0.002 18.0 0.4 0.0058 16.5 0.4 1.8 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase OppC_N PF12911.7 CAV18455.1 - 3.1 7.9 5.3 1.2 9.2 0.3 2.6 3 0 0 3 3 3 0 N-terminal TM domain of oligopeptide transport permease C Response_reg PF00072.24 CAV18456.1 - 4.5e-26 91.2 0.2 7.9e-26 90.4 0.2 1.4 1 0 0 1 1 1 1 Response regulator receiver domain HD PF01966.22 CAV18456.1 - 2.8e-18 66.3 0.2 8.3e-18 64.8 0.1 1.9 2 0 0 2 2 2 1 HD domain HD_5 PF13487.6 CAV18456.1 - 7.5e-18 64.5 0.0 5.8e-17 61.7 0.0 2.2 2 0 0 2 2 2 1 HD domain VPR PF00522.18 CAV18456.1 - 0.16 12.0 0.0 0.92 9.6 0.0 2.1 2 0 0 2 2 2 0 VPR/VPX protein Pkinase PF00069.25 CAV18457.1 - 1.5e-14 54.0 0.0 1.8e-14 53.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain RIO1 PF01163.22 CAV18457.1 - 9.4e-06 25.3 0.0 4.1e-05 23.3 0.0 1.9 1 1 1 2 2 2 1 RIO1 family Kinase-like PF14531.6 CAV18457.1 - 3.2e-05 23.4 0.0 4.2e-05 23.0 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Seadorna_VP7 PF07387.11 CAV18457.1 - 7.8e-05 21.9 0.0 0.0001 21.5 0.0 1.3 1 0 0 1 1 1 1 Seadornavirus VP7 APH PF01636.23 CAV18457.1 - 0.00033 20.6 0.0 0.00045 20.2 0.0 1.4 1 1 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.14 CAV18457.1 - 0.00038 19.9 0.0 0.00067 19.1 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_Tyr PF07714.17 CAV18457.1 - 0.0016 17.8 0.0 0.0019 17.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Choline_kinase PF01633.20 CAV18457.1 - 0.0077 15.8 0.2 0.021 14.4 0.1 1.8 2 0 0 2 2 2 1 Choline/ethanolamine kinase ImcF-related_N PF14331.6 CAV18458.1 - 1.1e-56 192.1 0.1 2.2e-56 191.1 0.1 1.5 1 0 0 1 1 1 1 ImcF-related N-terminal domain IcmF_C PF06744.12 CAV18458.1 - 3.5e-46 157.4 2.1 4.4e-46 157.1 0.7 2.0 2 0 0 2 2 2 1 Type VI secretion protein IcmF C-terminal IcmF-related PF06761.12 CAV18458.1 - 5.9e-32 111.4 0.6 5.9e-32 111.4 0.6 1.7 2 0 0 2 2 2 1 Intracellular multiplication and human macrophage-killing DotU PF09850.9 CAV18459.1 - 2e-34 119.2 0.0 3e-34 118.6 0.0 1.3 1 0 0 1 1 1 1 Type VI secretion system protein DotU SPOR PF05036.13 CAV18459.1 - 4.1e-07 30.3 0.0 9.3e-07 29.2 0.0 1.7 1 0 0 1 1 1 1 Sporulation related domain T6SS_VasE PF05936.12 CAV18460.1 - 1.8e-108 363.0 0.0 2e-108 362.8 0.0 1.0 1 0 0 1 1 1 1 Bacterial Type VI secretion, VC_A0110, EvfL, ImpJ, VasE T6SS-SciN PF12790.7 CAV18461.1 - 6.4e-28 96.9 2.1 7.8e-28 96.6 2.1 1.1 1 0 0 1 1 1 1 Type VI secretion lipoprotein, VasD, EvfM, TssJ, VC_A0113 FHA PF00498.26 CAV18462.1 - 2e-16 60.1 0.0 5.1e-16 58.8 0.0 1.8 1 0 0 1 1 1 1 FHA domain Yop-YscD_cpl PF16697.5 CAV18462.1 - 7.5e-10 39.0 0.0 1.7e-09 37.9 0.0 1.5 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain CHASE3 PF05227.13 CAV18462.1 - 0.013 15.4 0.3 0.023 14.6 0.3 1.4 1 0 0 1 1 1 0 CHASE3 domain FHA_2 PF17913.1 CAV18462.1 - 0.065 13.5 0.0 0.15 12.3 0.0 1.6 1 0 0 1 1 1 0 FHA domain DUF1825 PF08855.10 CAV18462.1 - 3.5 7.6 8.0 1.5 8.8 1.6 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF1825) SBP_bac_3 PF00497.20 CAV18463.1 - 1.7e-08 34.2 0.0 2e-08 33.9 0.0 1.1 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 ABC_sub_bind PF04392.12 CAV18464.1 - 1.5e-33 116.3 0.2 1.9e-33 115.9 0.2 1.1 1 0 0 1 1 1 1 ABC transporter substrate binding protein MFS_1 PF07690.16 CAV18465.1 - 2.9e-42 144.9 50.5 2.8e-39 135.1 32.9 3.3 2 2 1 3 3 3 2 Major Facilitator Superfamily Sugar_tr PF00083.24 CAV18465.1 - 1.4e-09 37.4 12.1 5.4e-09 35.4 2.6 5.3 2 1 3 5 5 5 3 Sugar (and other) transporter MFS_1_like PF12832.7 CAV18465.1 - 0.002 17.1 8.8 0.002 17.1 8.8 4.3 2 2 2 4 4 4 2 MFS_1 like family FtsH_ext PF06480.15 CAV18465.1 - 0.42 11.0 2.5 1.5 9.2 0.4 3.2 2 0 0 2 2 2 0 FtsH Extracellular AAA_2 PF07724.14 CAV18466.1 - 2.7e-41 141.5 1.3 2e-40 138.7 0.0 3.1 3 1 0 3 3 3 1 AAA domain (Cdc48 subfamily) AAA_lid_9 PF17871.1 CAV18466.1 - 1.8e-27 95.3 0.8 1.8e-27 95.3 0.8 2.2 2 0 0 2 2 2 1 AAA lid domain AAA PF00004.29 CAV18466.1 - 8.9e-20 71.5 0.0 4.4e-10 40.1 0.0 2.8 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 CAV18466.1 - 2.5e-14 53.4 0.2 6e-09 36.0 0.0 4.1 4 1 1 5 5 4 2 AAA domain (dynein-related subfamily) ClpB_D2-small PF10431.9 CAV18466.1 - 8.2e-12 45.0 0.0 2.8e-11 43.3 0.0 2.0 1 0 0 1 1 1 1 C-terminal, D2-small domain, of ClpB protein AAA_16 PF13191.6 CAV18466.1 - 2.1e-08 34.7 2.1 0.0042 17.5 0.0 5.1 4 2 0 4 4 4 2 AAA ATPase domain AAA_22 PF13401.6 CAV18466.1 - 7.8e-08 32.7 1.2 0.2 11.9 0.0 5.2 3 1 1 4 4 4 2 AAA domain AAA_33 PF13671.6 CAV18466.1 - 1.6e-06 28.3 0.4 0.046 13.9 0.0 3.2 3 1 0 3 3 2 2 AAA domain Mg_chelatase PF01078.21 CAV18466.1 - 4.3e-05 23.0 0.4 0.67 9.3 0.0 3.3 2 1 0 2 2 2 2 Magnesium chelatase, subunit ChlI IstB_IS21 PF01695.17 CAV18466.1 - 6.1e-05 22.8 0.0 0.11 12.2 0.0 2.6 2 0 0 2 2 2 2 IstB-like ATP binding protein AAA_7 PF12775.7 CAV18466.1 - 9e-05 22.1 0.0 0.57 9.7 0.0 2.6 2 0 0 2 2 2 2 P-loop containing dynein motor region Sigma54_activat PF00158.26 CAV18466.1 - 9.6e-05 22.1 0.1 0.0044 16.8 0.0 2.4 2 0 0 2 2 2 1 Sigma-54 interaction domain TniB PF05621.11 CAV18466.1 - 0.0001 21.8 0.0 0.19 11.2 0.0 3.6 3 1 1 4 4 3 1 Bacterial TniB protein RNA_helicase PF00910.22 CAV18466.1 - 0.00017 21.9 1.0 0.51 10.8 0.0 3.7 4 0 0 4 4 4 1 RNA helicase TIP49 PF06068.13 CAV18466.1 - 0.00022 20.5 1.0 0.76 8.9 0.0 3.3 2 1 1 3 3 3 1 TIP49 P-loop domain Zeta_toxin PF06414.12 CAV18466.1 - 0.00055 19.3 0.0 0.25 10.6 0.0 3.1 3 0 0 3 3 3 1 Zeta toxin AAA_18 PF13238.6 CAV18466.1 - 0.0012 19.4 0.1 0.3 11.6 0.0 2.9 2 0 0 2 2 2 1 AAA domain RuvB_N PF05496.12 CAV18466.1 - 0.0021 17.8 3.5 0.16 11.7 0.0 4.0 4 1 0 4 4 3 1 Holliday junction DNA helicase RuvB P-loop domain NACHT PF05729.12 CAV18466.1 - 0.0022 17.9 0.0 0.22 11.4 0.0 2.9 2 0 0 2 2 2 1 NACHT domain Torsin PF06309.11 CAV18466.1 - 0.0025 17.9 0.0 0.0068 16.5 0.0 1.7 1 0 0 1 1 1 1 Torsin AAA_23 PF13476.6 CAV18466.1 - 0.0026 18.3 7.8 0.66 10.4 0.0 3.5 3 1 0 3 3 3 1 AAA domain ResIII PF04851.15 CAV18466.1 - 0.0029 17.6 0.5 4.5 7.3 0.0 3.9 4 0 0 4 4 3 1 Type III restriction enzyme, res subunit AAA_25 PF13481.6 CAV18466.1 - 0.0029 17.2 1.0 3.2 7.3 0.0 3.6 3 1 1 4 4 4 1 AAA domain AAA_30 PF13604.6 CAV18466.1 - 0.005 16.6 0.4 0.56 9.9 0.2 3.1 2 1 0 2 2 2 1 AAA domain SRP54 PF00448.22 CAV18466.1 - 0.0081 15.8 1.5 0.63 9.6 0.1 2.9 3 0 0 3 3 3 1 SRP54-type protein, GTPase domain ABC_tran_CTD PF16326.5 CAV18466.1 - 0.018 15.3 10.2 0.018 15.3 10.2 3.0 2 1 1 3 3 2 0 ABC transporter C-terminal domain RsgA_GTPase PF03193.16 CAV18466.1 - 0.02 14.8 0.0 9.4 6.1 0.0 2.9 2 0 0 2 2 2 0 RsgA GTPase Rad17 PF03215.15 CAV18466.1 - 0.021 14.8 1.2 0.28 11.1 0.0 2.9 3 1 0 4 4 3 0 Rad17 P-loop domain Clp_N PF02861.20 CAV18466.1 - 0.023 14.8 0.1 2.2 8.5 0.0 3.1 3 0 0 3 3 2 0 Clp amino terminal domain, pathogenicity island component AAA_24 PF13479.6 CAV18466.1 - 0.046 13.4 0.2 4.7 6.9 0.0 3.0 2 1 0 2 2 2 0 AAA domain DUF815 PF05673.13 CAV18466.1 - 0.066 12.4 0.3 1.5 7.9 0.1 2.8 2 1 0 2 2 2 0 Protein of unknown function (DUF815) Roc PF08477.13 CAV18466.1 - 0.087 13.0 0.0 11 6.3 0.0 2.8 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase NTPase_1 PF03266.15 CAV18466.1 - 0.1 12.5 0.1 24 4.8 0.0 3.5 3 0 0 3 3 3 0 NTPase TsaE PF02367.17 CAV18466.1 - 0.11 12.5 0.0 12 5.9 0.0 2.5 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Hpr_kinase_C PF07475.12 CAV18466.1 - 0.26 10.8 2.7 0.33 10.5 0.0 2.5 3 0 0 3 3 3 0 HPr Serine kinase C-terminal domain T6SS_TssG PF06996.11 CAV18467.1 - 3.1e-48 164.6 0.7 3.4e-48 164.4 0.7 1.0 1 0 0 1 1 1 1 Type VI secretion, TssG RE_TdeIII PF09520.10 CAV18467.1 - 0.061 13.0 1.1 0.96 9.1 0.0 2.7 3 0 0 3 3 3 0 Type II restriction endonuclease, TdeIII T6SS_TssF PF05947.12 CAV18468.1 - 2.4e-128 429.3 0.0 2.7e-128 429.2 0.0 1.0 1 0 0 1 1 1 1 Type VI secretion system, TssF GPW_gp25 PF04965.14 CAV18470.1 - 8.7e-13 47.9 0.3 1.3e-12 47.3 0.2 1.3 2 0 0 2 2 2 1 Gene 25-like lysozyme Glutaredoxin2_C PF04399.13 CAV18470.1 - 0.056 13.3 0.1 0.4 10.5 0.1 1.9 1 1 1 2 2 2 0 Glutaredoxin 2, C terminal domain VipB PF05943.12 CAV18472.1 - 4.5e-111 371.6 0.0 6.1e-111 371.2 0.0 1.2 1 0 0 1 1 1 1 Type VI secretion protein, EvpB/VC_A0108, tail sheath VipB PF05943.12 CAV18475.1 - 1.4e-165 551.2 0.0 1.6e-165 551.0 0.0 1.0 1 0 0 1 1 1 1 Type VI secretion protein, EvpB/VC_A0108, tail sheath T6SS_VipA PF05591.12 CAV18476.1 - 6.6e-57 191.7 3.2 7.5e-57 191.5 3.2 1.0 1 0 0 1 1 1 1 Type VI secretion system, VipA, VC_A0107 or Hcp2 Pox_A11 PF05061.13 CAV18476.1 - 0.043 13.1 0.3 0.11 11.8 0.3 1.7 1 1 0 1 1 1 0 Poxvirus A11 Protein YihI PF04220.12 CAV18476.1 - 0.63 9.7 6.0 1 9.0 6.0 1.5 1 1 0 1 1 1 0 Der GTPase activator (YihI) T6SS_HCP PF05638.12 CAV18478.1 - 2.4e-19 70.0 0.0 2.9e-19 69.7 0.0 1.1 1 0 0 1 1 1 1 Type VI secretion system effector, Hcp ImpA_N PF06812.12 CAV18479.1 - 2.7e-23 82.3 0.1 4.6e-23 81.6 0.1 1.4 1 0 0 1 1 1 1 ImpA, N-terminal, type VI secretion system T6SS_VasJ PF16989.5 CAV18479.1 - 0.03 13.8 0.0 0.059 12.8 0.0 1.5 1 0 0 1 1 1 0 Type VI secretion, EvfE, EvfF, ImpA, BimE, VC_A0119, VasJ DEC-1_N PF04625.13 CAV18479.1 - 0.041 12.9 0.2 0.14 11.1 0.1 1.9 2 0 0 2 2 2 0 DEC-1 protein, N-terminal region PAAR_motif PF05488.13 CAV18482.1 - 4.3e-28 97.3 20.5 3.4e-25 88.0 8.0 2.8 1 1 2 3 3 3 3 PAAR motif DUF4150 PF13665.6 CAV18482.1 - 0.0039 17.3 4.2 0.022 14.9 0.1 2.6 1 1 1 2 2 2 2 Domain of unknown function (DUF4150) Phage_GPD PF05954.11 CAV18486.1 - 3.8e-13 49.4 0.0 7.1e-13 48.5 0.0 1.4 1 0 0 1 1 1 1 Phage late control gene D protein (GPD) Phage_base_V PF04717.12 CAV18486.1 - 0.00039 20.3 0.0 0.00087 19.2 0.0 1.5 1 0 0 1 1 1 1 Type VI secretion system, phage-baseplate injector DUF2345 PF10106.9 CAV18486.1 - 0.0011 18.8 1.7 0.0011 18.8 1.7 2.2 2 0 0 2 2 2 1 Uncharacterized protein conserved in bacteria (DUF2345) DUF3540 PF12059.8 CAV18486.1 - 0.066 13.0 1.4 0.18 11.6 1.4 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3540) Sarcoglycan_1 PF04790.13 CAV18486.1 - 0.39 10.0 8.4 0.15 11.4 3.8 2.0 1 1 1 2 2 2 0 Sarcoglycan complex subunit protein Phage_GPD PF05954.11 CAV18488.1 - 1.4e-40 139.5 0.2 1.6e-40 139.3 0.2 1.0 1 0 0 1 1 1 1 Phage late control gene D protein (GPD) PHB_acc_N PF07879.11 CAV18488.1 - 0.13 12.4 0.0 0.27 11.3 0.0 1.5 1 0 0 1 1 1 0 PHB/PHA accumulation regulator DNA-binding domain Phasin PF05597.11 CAV18491.1 - 0.071 13.1 1.4 0.33 11.0 0.2 2.7 2 1 0 2 2 2 0 Poly(hydroxyalcanoate) granule associated protein (phasin) SBP_bac_3 PF00497.20 CAV18493.1 - 1.7e-21 76.7 0.0 3.7e-21 75.6 0.0 1.5 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 HD_5 PF13487.6 CAV18493.1 - 1e-19 70.5 0.1 2.9e-19 69.1 0.1 1.9 1 0 0 1 1 1 1 HD domain HD PF01966.22 CAV18493.1 - 1.3e-06 28.6 1.0 0.0045 17.2 0.1 2.9 3 0 0 3 3 3 2 HD domain HAMP PF00672.25 CAV18493.1 - 0.026 14.9 0.0 0.085 13.3 0.0 2.0 2 0 0 2 2 2 0 HAMP domain FCD PF07729.12 CAV18494.1 - 9.1e-27 94.0 3.0 1.3e-26 93.4 3.0 1.2 1 0 0 1 1 1 1 FCD domain GntR PF00392.21 CAV18494.1 - 3.1e-15 55.6 0.1 3.1e-15 55.6 0.1 2.2 3 0 0 3 3 3 1 Bacterial regulatory proteins, gntR family HTH_11 PF08279.12 CAV18494.1 - 0.081 12.9 0.0 0.37 10.8 0.0 2.1 2 0 0 2 2 2 0 HTH domain MarR PF01047.22 CAV18494.1 - 0.087 12.8 0.0 0.23 11.4 0.0 1.7 1 0 0 1 1 1 0 MarR family PEP_mutase PF13714.6 CAV18495.1 - 1.7e-45 155.3 2.3 2e-45 155.1 2.3 1.0 1 0 0 1 1 1 1 Phosphoenolpyruvate phosphomutase ICL PF00463.21 CAV18495.1 - 1.1e-13 50.5 1.3 1.8e-13 49.9 1.3 1.3 1 0 0 1 1 1 1 Isocitrate lyase family MTHFR PF02219.17 CAV18495.1 - 0.018 14.4 0.0 0.028 13.7 0.0 1.3 1 0 0 1 1 1 0 Methylenetetrahydrofolate reductase IMPDH PF00478.25 CAV18495.1 - 0.039 12.9 0.2 0.061 12.3 0.2 1.3 1 0 0 1 1 1 0 IMP dehydrogenase / GMP reductase domain Citrate_synt PF00285.21 CAV18496.1 - 5.6e-112 374.4 0.1 6.6e-112 374.2 0.1 1.0 1 0 0 1 1 1 1 Citrate synthase, C-terminal domain Aconitase PF00330.20 CAV18498.1 - 3.8e-148 494.3 0.0 5e-148 493.9 0.0 1.1 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 CAV18498.1 - 4.8e-29 101.3 0.0 1e-28 100.3 0.0 1.6 1 0 0 1 1 1 1 Aconitase C-terminal domain PrpF PF04303.13 CAV18499.1 - 4.1e-169 562.4 2.2 4.6e-169 562.2 2.2 1.0 1 0 0 1 1 1 1 PrpF protein AMP-binding PF00501.28 CAV18500.1 - 7.7e-84 281.7 0.0 1e-83 281.3 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 CAV18500.1 - 5e-25 88.3 0.5 1.2e-24 87.1 0.5 1.7 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain ACAS_N PF16177.5 CAV18500.1 - 1.6e-13 50.3 4.0 1.6e-13 50.3 2.1 2.0 2 0 0 2 2 2 1 Acetyl-coenzyme A synthetase N-terminus Gly-zipper_YMGG PF13441.6 CAV18502.1 - 1.3e-05 24.9 19.4 1.9e-05 24.3 19.4 1.3 1 0 0 1 1 1 1 YMGG-like Gly-zipper Gly-zipper_Omp PF13488.6 CAV18502.1 - 2.5e-05 24.2 15.5 4e-05 23.5 15.5 1.3 1 0 0 1 1 1 1 Glycine zipper Gly-zipper_OmpA PF13436.6 CAV18502.1 - 8.7e-05 22.2 19.9 0.00012 21.7 19.9 1.2 1 0 0 1 1 1 1 Glycine-zipper domain Rick_17kDa_Anti PF05433.15 CAV18502.1 - 0.00086 19.1 23.4 0.0013 18.5 23.4 1.2 1 0 0 1 1 1 1 Glycine zipper 2TM domain TraT PF05818.12 CAV18502.1 - 0.0085 15.8 3.4 0.0094 15.7 3.4 1.2 1 0 0 1 1 1 1 Enterobacterial TraT complement resistance protein I_LWEQ PF01608.17 CAV18502.1 - 0.023 14.9 0.4 0.031 14.5 0.4 1.1 1 0 0 1 1 1 0 I/LWEQ domain Bacteriocin_IIc PF10439.9 CAV18502.1 - 0.034 14.3 12.3 0.058 13.5 12.3 1.3 1 0 0 1 1 1 0 Bacteriocin class II with double-glycine leader peptide LPAM_1 PF08139.12 CAV18502.1 - 0.047 14.2 0.9 0.047 14.2 0.9 1.9 2 0 0 2 2 2 0 Prokaryotic membrane lipoprotein lipid attachment site Acetyltransf_1 PF00583.25 CAV18504.1 - 1.2e-13 51.3 0.0 1.5e-13 51.0 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 CAV18504.1 - 1.1e-12 48.0 0.0 1.8e-12 47.3 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 CAV18504.1 - 1.8e-10 41.1 0.0 2.8e-10 40.5 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 CAV18504.1 - 1.6e-09 38.1 0.0 5.2e-09 36.4 0.0 1.7 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 CAV18504.1 - 0.00038 20.5 0.0 0.00052 20.1 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 CAV18504.1 - 0.00049 20.0 0.0 0.00072 19.5 0.0 1.2 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_3 PF13302.7 CAV18504.1 - 0.019 15.6 0.0 0.026 15.2 0.0 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_13 PF13880.6 CAV18504.1 - 0.07 13.1 0.0 0.14 12.1 0.0 1.6 1 0 0 1 1 1 0 ESCO1/2 acetyl-transferase DUF1896 PF08989.10 CAV18504.1 - 0.074 13.2 0.1 0.12 12.4 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1896) PAP2 PF01569.21 CAV18506.1 - 1e-12 48.0 6.5 1e-12 48.0 6.5 2.4 3 0 0 3 3 3 1 PAP2 superfamily NUDIX PF00293.28 CAV18506.1 - 2e-10 40.8 0.0 3.4e-10 40.1 0.0 1.3 1 0 0 1 1 1 1 NUDIX domain Glycophorin_A PF01102.18 CAV18506.1 - 0.04 14.2 1.4 3.4 7.9 0.1 3.2 3 0 0 3 3 3 0 Glycophorin A Fimbrial_PilY2 PF14481.6 CAV18506.1 - 0.05 13.3 0.2 0.13 12.0 0.0 1.8 2 0 0 2 2 2 0 Type 4 fimbrial biogenesis protein PilY2 Hydrolase_3 PF08282.12 CAV18508.1 - 3.8e-65 220.1 4.3 4.3e-65 220.0 4.3 1.0 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase S6PP PF05116.13 CAV18508.1 - 2.5e-13 50.1 0.0 5.3e-09 36.0 0.0 2.1 2 0 0 2 2 2 2 Sucrose-6F-phosphate phosphohydrolase Hydrolase PF00702.26 CAV18508.1 - 2.5e-08 34.4 1.8 0.0048 17.2 0.3 3.6 1 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase HAD PF12710.7 CAV18508.1 - 5.3e-05 23.7 0.0 0.23 11.8 0.0 3.2 2 1 1 3 3 3 2 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 CAV18508.1 - 0.0001 22.4 0.6 0.37 10.9 0.1 2.6 2 2 0 2 2 2 2 Haloacid dehalogenase-like hydrolase Hydrolase_6 PF13344.6 CAV18508.1 - 0.00037 20.5 0.1 0.0015 18.6 0.0 2.1 2 1 0 2 2 2 1 Haloacid dehalogenase-like hydrolase SE PF08491.10 CAV18508.1 - 0.073 12.1 0.0 0.1 11.6 0.0 1.3 1 0 0 1 1 1 0 Squalene epoxidase Fer4_14 PF13394.6 CAV18509.1 - 5.9e-12 45.8 0.1 1e-11 45.0 0.1 1.4 1 0 0 1 1 1 1 4Fe-4S single cluster domain Radical_SAM PF04055.21 CAV18509.1 - 1.2e-07 32.2 0.0 1.5e-07 31.9 0.0 1.3 1 0 0 1 1 1 1 Radical SAM superfamily Fer4_12 PF13353.6 CAV18509.1 - 2e-06 28.1 0.0 2.7e-06 27.7 0.0 1.3 1 0 0 1 1 1 1 4Fe-4S single cluster domain AAA_9 PF12781.7 CAV18509.1 - 0.074 12.2 0.0 0.12 11.5 0.0 1.3 1 0 0 1 1 1 0 ATP-binding dynein motor region QueC PF06508.13 CAV18511.1 - 4.4e-76 255.1 0.0 4.9e-76 254.9 0.0 1.0 1 0 0 1 1 1 1 Queuosine biosynthesis protein QueC NAD_synthase PF02540.17 CAV18511.1 - 0.00068 18.8 0.0 0.0011 18.1 0.0 1.4 1 0 0 1 1 1 1 NAD synthase Arginosuc_synth PF00764.19 CAV18511.1 - 0.00074 18.9 0.1 0.0011 18.4 0.1 1.2 1 0 0 1 1 1 1 Arginosuccinate synthase ATP_bind_3 PF01171.20 CAV18511.1 - 0.0028 17.5 0.1 0.0043 16.8 0.1 1.3 1 0 0 1 1 1 1 PP-loop family PAPS_reduct PF01507.19 CAV18511.1 - 0.0049 16.9 0.1 0.0072 16.4 0.1 1.2 1 0 0 1 1 1 1 Phosphoadenosine phosphosulfate reductase family Asn_synthase PF00733.21 CAV18511.1 - 0.0084 15.8 0.1 0.011 15.4 0.1 1.1 1 0 0 1 1 1 1 Asparagine synthase Diphthami_syn_2 PF01902.17 CAV18511.1 - 0.0096 15.4 0.0 0.013 15.0 0.0 1.3 1 0 0 1 1 1 1 Diphthamide synthase QueC PF06508.13 CAV18513.1 - 9.6e-82 273.5 0.0 1.1e-81 273.4 0.0 1.0 1 0 0 1 1 1 1 Queuosine biosynthesis protein QueC ATP_bind_3 PF01171.20 CAV18513.1 - 0.0044 16.8 0.2 0.026 14.3 0.1 1.9 2 0 0 2 2 2 1 PP-loop family NAD_synthase PF02540.17 CAV18513.1 - 0.096 11.8 0.1 0.17 11.0 0.1 1.4 2 0 0 2 2 2 0 NAD synthase Asn_synthase PF00733.21 CAV18513.1 - 0.25 10.9 0.1 0.33 10.6 0.1 1.1 1 0 0 1 1 1 0 Asparagine synthase YoaP PF14268.6 CAV18516.1 - 0.11 12.0 0.1 0.2 11.2 0.1 1.3 1 0 0 1 1 1 0 YoaP-like HTH_3 PF01381.22 CAV18518.1 - 3.5e-12 46.2 0.3 3e-11 43.2 0.3 2.0 1 1 0 1 1 1 1 Helix-turn-helix HTH_19 PF12844.7 CAV18518.1 - 1.3e-11 44.4 0.0 2e-11 43.8 0.0 1.2 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_31 PF13560.6 CAV18518.1 - 1.3e-06 28.6 0.0 2.5e-06 27.7 0.0 1.5 1 1 0 1 1 1 1 Helix-turn-helix domain MqsA_antitoxin PF15731.5 CAV18518.1 - 0.014 15.5 0.0 0.024 14.8 0.0 1.3 1 0 0 1 1 1 0 Antitoxin component of bacterial toxin-antitoxin system, MqsA HTH_24 PF13412.6 CAV18518.1 - 0.028 14.0 0.0 0.25 10.9 0.0 2.1 2 0 0 2 2 2 0 Winged helix-turn-helix DNA-binding Coagulase PF08764.10 CAV18520.1 - 0.031 14.5 1.1 0.037 14.2 1.1 1.1 1 0 0 1 1 1 0 Staphylococcus aureus coagulase ResIII PF04851.15 CAV18522.1 - 4.8e-13 49.5 0.0 6.7e-11 42.5 0.0 3.0 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 CAV18522.1 - 1.2e-06 28.9 0.0 6.6e-06 26.4 0.0 2.2 3 0 0 3 3 3 1 AAA domain Helicase_C PF00271.31 CAV18522.1 - 0.00018 21.8 0.1 0.001 19.4 0.1 2.2 2 1 0 2 2 2 1 Helicase conserved C-terminal domain DUF2075 PF09848.9 CAV18522.1 - 0.0015 17.9 0.0 0.0046 16.2 0.0 1.7 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) AAA PF00004.29 CAV18522.1 - 0.0096 16.3 0.0 0.11 12.9 0.0 2.3 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_7 PF12775.7 CAV18522.1 - 0.028 14.0 0.0 0.056 12.9 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region ArsA_ATPase PF02374.15 CAV18522.1 - 0.044 13.0 0.4 3.1 6.9 0.1 2.3 2 1 0 2 2 2 0 Anion-transporting ATPase DnaB_C PF03796.15 CAV18522.1 - 0.057 12.8 0.0 0.12 11.7 0.0 1.5 1 0 0 1 1 1 0 DnaB-like helicase C terminal domain KdpD PF02702.17 CAV18522.1 - 0.11 11.9 0.0 15 5.0 0.0 2.5 2 1 0 2 2 2 0 Osmosensitive K+ channel His kinase sensor domain K-box PF01486.17 CAV18524.1 - 0.45 10.7 3.1 0.27 11.4 0.8 1.8 2 0 0 2 2 2 0 K-box region DnaJ PF00226.31 CAV18525.1 - 5.7e-08 32.8 0.0 1.9e-07 31.1 0.0 2.0 1 0 0 1 1 1 1 DnaJ domain Filament PF00038.21 CAV18525.1 - 0.012 15.2 5.4 0.012 15.2 5.4 1.5 2 0 0 2 2 2 0 Intermediate filament protein SPOR PF05036.13 CAV18525.1 - 0.014 15.7 0.0 0.046 14.1 0.0 1.8 1 0 0 1 1 1 0 Sporulation related domain DUF4410 PF14366.6 CAV18525.1 - 0.016 15.1 0.2 0.03 14.2 0.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4410) SpoIIIAH PF12685.7 CAV18525.1 - 0.04 13.7 0.3 0.04 13.7 0.3 2.6 2 1 1 3 3 3 0 SpoIIIAH-like protein Bud13 PF09736.9 CAV18525.1 - 0.7 10.3 3.7 1.7 9.0 3.7 1.6 1 0 0 1 1 1 0 Pre-mRNA-splicing factor of RES complex Baculo_PEP_C PF04513.12 CAV18530.1 - 3.1e-09 37.0 37.9 5.3e-05 23.3 3.1 6.6 3 1 3 6 6 6 3 Baculovirus polyhedron envelope protein, PEP, C terminus Apolipoprotein PF01442.18 CAV18530.1 - 3.3e-09 36.9 34.4 0.00034 20.5 14.0 4.3 1 1 3 4 4 4 4 Apolipoprotein A1/A4/E domain Prominin PF05478.11 CAV18530.1 - 1.6e-06 26.4 32.3 0.0016 16.5 10.0 3.1 1 1 2 3 3 3 3 Prominin ApoLp-III PF07464.11 CAV18530.1 - 1.8e-06 28.1 40.2 0.0051 16.9 12.9 4.8 1 1 4 5 5 5 4 Apolipophorin-III precursor (apoLp-III) MotA_ExbB PF01618.16 CAV18530.1 - 7.3e-05 22.5 1.7 7.3e-05 22.5 1.7 4.9 4 3 2 6 6 6 1 MotA/TolQ/ExbB proton channel family DUF885 PF05960.11 CAV18530.1 - 0.0015 18.3 15.9 0.12 12.0 1.4 2.3 1 1 1 2 2 2 2 Bacterial protein of unknown function (DUF885) DUF883 PF05957.13 CAV18530.1 - 0.003 18.1 21.4 1.4 9.6 3.5 6.5 2 2 3 6 6 6 2 Bacterial protein of unknown function (DUF883) FliJ PF02050.16 CAV18530.1 - 0.012 15.8 2.0 0.012 15.8 2.0 4.5 3 2 2 5 5 5 0 Flagellar FliJ protein DUF4199 PF13858.6 CAV18530.1 - 0.021 15.2 0.1 0.021 15.2 0.1 3.2 4 0 0 4 4 4 0 Protein of unknown function (DUF4199) Collagen_mid PF15984.5 CAV18530.1 - 0.041 13.6 8.4 3.6 7.3 0.2 4.3 3 1 2 5 5 5 0 Bacterial collagen, middle region DUF1664 PF07889.12 CAV18530.1 - 0.041 13.9 39.1 0.21 11.6 1.0 6.6 1 1 6 7 7 7 0 Protein of unknown function (DUF1664) ANAPC4 PF12896.7 CAV18530.1 - 0.058 12.9 12.8 0.098 12.1 0.1 5.0 2 2 1 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 4 DUF5345 PF17280.2 CAV18530.1 - 0.22 11.5 1.8 0.93 9.5 1.8 2.1 1 0 0 1 1 1 0 Family of unknown function (DUF5345) IL28A PF15177.6 CAV18530.1 - 0.23 11.3 3.4 0.78 9.6 1.2 2.6 2 0 0 2 2 2 0 Interleukin-28A EzrA PF06160.12 CAV18530.1 - 0.38 8.9 31.5 0.21 9.8 6.8 3.5 1 1 2 3 3 3 0 Septation ring formation regulator, EzrA Exonuc_VII_L PF02601.15 CAV18530.1 - 0.49 9.9 28.6 1.8e+04 -10.6 28.6 3.8 1 1 0 1 1 0 0 Exonuclease VII, large subunit Cor1 PF04803.12 CAV18530.1 - 2.7 8.2 35.4 2.5 8.3 1.1 6.6 2 2 3 6 6 6 0 Cor1/Xlr/Xmr conserved region DUF4854 PF16146.5 CAV18530.1 - 3.3 8.1 24.7 21 5.5 0.1 7.0 2 1 5 8 8 8 0 Domain of unknown function (DUF4854) YtxH PF12732.7 CAV18530.1 - 3.7 8.1 26.4 2e+03 -0.6 0.0 7.3 2 1 0 2 2 1 0 YtxH-like protein Spore_III_AB PF09548.10 CAV18530.1 - 7 6.7 16.9 5.7 7.0 1.6 4.3 1 1 3 5 5 5 0 Stage III sporulation protein AB (spore_III_AB) UPF0184 PF03670.13 CAV18530.1 - 7.7 7.0 13.7 9.9 6.6 0.8 4.3 3 2 1 4 4 4 0 Uncharacterised protein family (UPF0184) Mating_N PF12731.7 CAV18530.1 - 8.1 6.6 13.5 8.9 6.5 0.4 5.7 3 2 0 5 5 5 0 Mating-type protein beta 1 WXG100 PF06013.12 CAV18530.1 - 8.6 6.7 27.1 6.4 7.1 3.7 7.2 3 2 2 6 6 6 0 Proteins of 100 residues with WXG OmpA PF00691.20 CAV18531.1 - 7.1e-09 35.9 0.5 1.3e-08 35.1 0.0 1.7 2 0 0 2 2 2 1 OmpA family KNOX2 PF03791.13 CAV18531.1 - 0.06 12.9 0.1 0.89 9.1 0.0 2.3 2 0 0 2 2 2 0 KNOX2 domain zf-C2H2_8 PF15909.5 CAV18533.1 - 0.00028 21.1 0.9 0.001 19.3 0.1 2.3 2 0 0 2 2 2 1 C2H2-type zinc ribbon HNH_3 PF13392.6 CAV18533.1 - 0.0015 18.2 4.3 0.0037 17.0 4.3 1.6 1 0 0 1 1 1 1 HNH endonuclease HNH PF01844.23 CAV18533.1 - 0.0033 17.6 9.2 0.0033 17.6 9.2 2.3 2 0 0 2 2 2 1 HNH endonuclease Cytochrome_C7 PF14522.6 CAV18533.1 - 0.063 13.3 5.5 0.034 14.1 2.6 1.9 2 0 0 2 2 2 0 Cytochrome c7 and related cytochrome c Apolipoprotein PF01442.18 CAV18535.1 - 3.8e-08 33.4 39.1 0.0055 16.6 18.5 4.4 1 1 3 4 4 4 3 Apolipoprotein A1/A4/E domain Baculo_PEP_C PF04513.12 CAV18535.1 - 2.5e-06 27.6 28.3 0.0065 16.5 4.1 5.2 1 1 2 4 4 4 2 Baculovirus polyhedron envelope protein, PEP, C terminus ApoLp-III PF07464.11 CAV18535.1 - 4.2e-05 23.7 44.3 0.0012 18.9 13.2 5.3 2 2 2 5 5 5 3 Apolipophorin-III precursor (apoLp-III) MotA_ExbB PF01618.16 CAV18535.1 - 0.00081 19.1 1.2 0.00081 19.1 1.2 3.6 3 1 1 4 4 4 1 MotA/TolQ/ExbB proton channel family PLC-beta_C PF08703.10 CAV18535.1 - 0.077 13.0 29.7 0.13 12.2 8.8 3.7 2 2 1 3 3 3 0 PLC-beta C terminal BCDHK_Adom3 PF10436.9 CAV18535.1 - 0.079 12.8 3.1 0.11 12.3 0.1 2.6 2 1 0 2 2 2 0 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase KIP1 PF07765.12 CAV18535.1 - 0.18 12.0 7.4 0.58 10.3 1.3 3.8 2 1 1 3 3 3 0 KIP1-like protein Bin3 PF06859.12 CAV18535.1 - 0.33 11.6 0.1 0.33 11.6 0.1 2.7 2 1 1 3 3 3 0 Bicoid-interacting protein 3 (Bin3) DUF1664 PF07889.12 CAV18535.1 - 0.37 10.8 27.2 12 6.0 0.4 6.1 2 2 4 6 6 6 0 Protein of unknown function (DUF1664) CdiI_2 PF18593.1 CAV18535.1 - 0.54 11.0 9.0 2.1 9.0 0.1 4.4 3 2 0 4 4 4 0 CdiI immunity protein DUF3584 PF12128.8 CAV18535.1 - 1.2 6.5 36.9 5.8 4.3 17.6 2.7 1 1 0 1 1 1 0 Protein of unknown function (DUF3584) Cor1 PF04803.12 CAV18535.1 - 2.1 8.5 28.7 0.49 10.6 10.9 4.3 3 2 0 3 3 3 0 Cor1/Xlr/Xmr conserved region LpxB PF02684.15 CAV18535.1 - 4.3 6.1 9.9 0.11 11.3 0.3 2.7 3 0 0 3 3 3 0 Lipid-A-disaccharide synthetase OmpA PF00691.20 CAV18536.1 - 1.9e-08 34.5 0.8 1e-07 32.2 0.1 2.0 2 0 0 2 2 2 1 OmpA family EH_Signature PF15611.6 CAV18537.1 - 8.5e-13 48.5 2.0 8.5e-13 48.5 2.0 1.9 2 0 0 2 2 2 1 EH_Signature domain Propep_M14 PF02244.16 CAV18537.1 - 0.05 14.0 0.1 2.8 8.4 0.0 2.7 2 0 0 2 2 2 0 Carboxypeptidase activation peptide Cas_NE0113 PF09623.10 CAV18538.1 - 3e-50 170.8 0.0 4.8e-50 170.2 0.0 1.3 1 0 0 1 1 1 1 CRISPR-associated protein NE0113 (Cas_NE0113) ResIII PF04851.15 CAV18539.1 - 2.6e-38 131.7 0.2 2.6e-38 131.7 0.2 3.4 4 0 0 4 4 4 1 Type III restriction enzyme, res subunit EcoEI_R_C PF08463.10 CAV18539.1 - 1.3e-29 103.5 5.9 1.3e-29 103.5 5.9 3.3 3 0 0 3 3 3 1 EcoEI R protein C-terminal HSDR_N PF04313.14 CAV18539.1 - 3.8e-16 59.6 1.9 1.6e-14 54.3 0.0 3.8 4 1 0 4 4 4 1 Type I restriction enzyme R protein N terminus (HSDR_N) SWI2_SNF2 PF18766.1 CAV18539.1 - 1.3e-14 54.4 0.4 4e-14 52.8 0.4 1.8 1 0 0 1 1 1 1 SWI2/SNF2 ATPase Helicase_C PF00271.31 CAV18539.1 - 2.3e-10 40.8 0.8 1.1e-09 38.6 0.2 2.5 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 CAV18539.1 - 2.8e-09 37.0 1.8 2.5e-08 33.9 0.2 3.2 3 0 0 3 3 3 1 DEAD/DEAH box helicase DUF4145 PF13643.6 CAV18539.1 - 2.8e-05 24.2 0.1 0.0002 21.4 0.0 2.6 2 0 0 2 2 2 1 Domain of unknown function (DUF4145) DUF2075 PF09848.9 CAV18539.1 - 0.0027 17.0 0.0 0.01 15.1 0.0 2.0 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) UvrD-helicase PF00580.21 CAV18539.1 - 0.0098 15.4 0.1 0.0098 15.4 0.1 3.7 3 1 0 3 3 3 2 UvrD/REP helicase N-terminal domain PhoH PF02562.16 CAV18539.1 - 0.02 14.4 0.1 0.19 11.2 0.1 2.4 2 0 0 2 2 2 0 PhoH-like protein AAA_22 PF13401.6 CAV18539.1 - 0.052 13.8 1.0 0.61 10.4 0.0 3.2 3 0 0 3 3 2 0 AAA domain AAA_11 PF13086.6 CAV18539.1 - 0.79 9.4 15.0 8.4 6.1 5.9 4.4 4 1 0 4 4 4 0 AAA domain TolA_bind_tri PF16331.5 CAV18539.1 - 9.4 6.4 12.9 6.4 6.9 0.0 3.7 3 0 0 3 3 3 0 TolA binding protein trimerisation N6_Mtase PF02384.16 CAV18540.1 - 8e-85 284.8 0.0 1.1e-84 284.4 0.0 1.1 1 0 0 1 1 1 1 N-6 DNA Methylase HsdM_N PF12161.8 CAV18540.1 - 8.6e-11 42.6 0.4 1.3e-09 38.8 0.1 2.7 2 1 0 2 2 2 1 HsdM N-terminal domain UPF0020 PF01170.18 CAV18540.1 - 0.0012 18.6 0.0 0.0057 16.4 0.0 2.1 1 1 0 1 1 1 1 Putative RNA methylase family UPF0020 FtsK_SpoIIIE PF01580.18 CAV18541.1 - 0.04 13.3 0.2 0.04 13.3 0.2 1.0 1 0 0 1 1 1 0 FtsK/SpoIIIE family Methylase_S PF01420.19 CAV18542.1 - 5.6e-33 114.5 0.0 4.1e-17 62.9 0.0 2.2 2 0 0 2 2 2 2 Type I restriction modification DNA specificity domain PutA_N PF18083.1 CAV18542.1 - 0.034 14.2 0.1 0.58 10.2 0.1 2.7 2 0 0 2 2 2 0 Proline utilization A N-terminal domain NPV_P10 PF05531.12 CAV18542.1 - 0.11 12.9 0.7 1.3 9.6 0.1 2.6 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein SKA2 PF16740.5 CAV18542.1 - 0.66 9.8 5.3 1.6 8.6 1.6 3.0 3 1 0 3 3 3 0 Spindle and kinetochore-associated protein 2 THOC7 PF05615.13 CAV18543.1 - 0.039 14.2 3.1 0.68 10.2 2.4 2.2 2 0 0 2 2 2 0 Tho complex subunit 7 SesA PF17107.5 CAV18543.1 - 0.08 13.1 0.5 0.17 12.1 0.5 1.5 1 0 0 1 1 1 0 N-terminal domain on NACHT_NTPase and P-loop NTPases pPIWI_RE_REase PF18154.1 CAV18543.1 - 0.18 11.8 0.0 0.35 10.8 0.0 1.4 1 0 0 1 1 1 0 REase associating with pPIWI_RE AAA_5 PF07728.14 CAV18544.1 - 2.2e-12 47.2 0.3 4.2e-09 36.5 0.0 3.5 3 1 0 3 3 3 2 AAA domain (dynein-related subfamily) AAA PF00004.29 CAV18544.1 - 1.2e-05 25.8 0.5 0.13 12.7 0.0 3.4 3 0 0 3 3 3 2 ATPase family associated with various cellular activities (AAA) IstB_IS21 PF01695.17 CAV18544.1 - 0.05 13.3 0.0 0.14 11.8 0.0 1.7 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA_16 PF13191.6 CAV18544.1 - 0.061 13.7 0.0 0.18 12.1 0.0 1.9 1 0 0 1 1 1 0 AAA ATPase domain PhoH PF02562.16 CAV18544.1 - 0.077 12.4 0.0 0.2 11.1 0.0 1.6 1 0 0 1 1 1 0 PhoH-like protein AAA_25 PF13481.6 CAV18544.1 - 0.097 12.2 0.0 0.21 11.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_19 PF13245.6 CAV18544.1 - 0.14 12.5 0.0 1.5 9.1 0.0 2.4 1 1 0 1 1 1 0 AAA domain AAA_11 PF13086.6 CAV18544.1 - 0.19 11.5 0.1 0.19 11.5 0.1 2.2 2 1 1 3 3 3 0 AAA domain McrBC PF10117.9 CAV18545.1 - 2.5e-98 329.1 1.8 3.1e-98 328.9 1.8 1.1 1 0 0 1 1 1 1 McrBC 5-methylcytosine restriction system component HSDR_N_2 PF13588.6 CAV18545.1 - 0.019 15.0 0.2 0.15 12.1 0.0 2.2 2 0 0 2 2 2 0 Type I restriction enzyme R protein N terminus (HSDR_N) DEAD PF00270.29 CAV18548.1 - 1.1e-18 67.7 0.0 3.5e-18 66.0 0.0 1.9 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CAV18548.1 - 7.5e-11 42.4 0.1 6.2e-10 39.4 0.0 2.5 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DUF1998 PF09369.10 CAV18548.1 - 2.3e-08 34.7 0.2 1e-07 32.6 0.2 2.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1998) ResIII PF04851.15 CAV18548.1 - 7.4e-06 26.1 0.0 1.5e-05 25.1 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DUF167 PF02594.16 CAV18548.1 - 0.011 15.8 0.1 0.042 14.0 0.0 2.0 2 0 0 2 2 2 0 Uncharacterised ACR, YggU family COG1872 AAA_lid_7 PF17867.1 CAV18548.1 - 0.16 12.2 0.2 0.43 10.8 0.2 1.7 1 0 0 1 1 1 0 Midasin AAA lid domain Shugoshin_N PF07558.11 CAV18549.1 - 0.0011 18.8 0.1 0.0021 17.9 0.1 1.5 1 0 0 1 1 1 1 Shugoshin N-terminal coiled-coil region CotJB PF12652.7 CAV18549.1 - 0.047 13.9 0.2 0.11 12.8 0.2 1.7 1 1 0 1 1 1 0 CotJB protein KIAA1430 PF13879.6 CAV18549.1 - 0.054 14.2 4.9 0.088 13.6 4.9 1.3 1 0 0 1 1 1 0 KIAA1430 homologue RcsC PF09456.10 CAV18550.1 - 0.15 12.0 0.1 0.92 9.5 0.0 2.3 2 0 0 2 2 2 0 RcsC Alpha-Beta-Loop (ABL) Herpes_IE2_3 PF03361.14 CAV18551.1 - 0.075 12.9 0.0 0.21 11.4 0.0 1.7 1 0 0 1 1 1 0 Herpes virus intermediate/early protein 2/3 Phage_integrase PF00589.22 CAV18552.1 - 5e-07 29.7 0.0 0.00077 19.3 0.0 2.5 2 0 0 2 2 2 2 Phage integrase family GGDEF PF00990.21 CAV18553.1 - 3.3e-34 118.0 0.2 1.1e-33 116.3 0.2 2.0 1 0 0 1 1 1 1 Diguanylate cyclase, GGDEF domain TPR_12 PF13424.6 CAV18553.1 - 2.7e-26 91.6 33.0 2.7e-09 37.2 1.5 5.5 3 1 3 7 7 6 4 Tetratricopeptide repeat TPR_2 PF07719.17 CAV18553.1 - 1.1e-11 43.9 20.8 0.0024 17.9 0.1 7.4 7 0 0 7 7 7 4 Tetratricopeptide repeat TPR_8 PF13181.6 CAV18553.1 - 2.3e-11 42.9 25.6 0.012 15.8 0.1 7.0 8 0 0 8 8 8 5 Tetratricopeptide repeat TPR_1 PF00515.28 CAV18553.1 - 3.3e-09 36.2 25.7 0.0018 18.0 0.2 7.0 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_10 PF13374.6 CAV18553.1 - 5.9e-07 29.2 18.8 0.018 14.9 0.2 6.4 7 0 0 7 7 6 3 Tetratricopeptide repeat TPR_7 PF13176.6 CAV18553.1 - 8.5e-06 25.4 18.5 0.17 12.0 0.0 7.1 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_16 PF13432.6 CAV18553.1 - 1.4e-05 25.7 10.8 0.057 14.1 1.7 4.7 2 1 2 4 4 4 3 Tetratricopeptide repeat TPR_MalT PF17874.1 CAV18553.1 - 0.00033 20.1 12.8 0.00033 20.1 12.8 2.3 2 0 0 2 2 2 1 MalT-like TPR region SNAP PF14938.6 CAV18553.1 - 0.00086 18.8 10.2 0.012 15.1 0.5 2.6 1 1 1 2 2 2 2 Soluble NSF attachment protein, SNAP TPR_14 PF13428.6 CAV18553.1 - 0.0053 17.5 13.6 5.1 8.2 0.0 6.5 4 2 3 7 7 5 1 Tetratricopeptide repeat TPR_19 PF14559.6 CAV18553.1 - 0.15 12.6 18.5 0.23 12.0 0.1 5.1 3 1 2 5 5 5 0 Tetratricopeptide repeat YfdX PF10938.8 CAV18553.1 - 0.19 11.6 2.3 0.18 11.8 0.3 2.0 2 0 0 2 2 2 0 YfdX protein TPR_17 PF13431.6 CAV18553.1 - 0.24 11.8 0.2 0.24 11.8 0.2 4.3 5 0 0 5 5 4 0 Tetratricopeptide repeat DUF2750 PF11042.8 CAV18554.1 - 2.1e-33 114.4 3.0 2.5e-33 114.2 3.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2750) OmpA PF00691.20 CAV18555.1 - 1.5e-18 67.0 0.0 2.2e-18 66.4 0.0 1.2 1 0 0 1 1 1 1 OmpA family Pilus_CpaD PF09476.10 CAV18555.1 - 0.058 13.1 0.0 0.088 12.5 0.0 1.2 1 0 0 1 1 1 0 Pilus biogenesis CpaD protein (pilus_cpaD) OEP PF02321.18 CAV18556.1 - 2.1e-50 171.2 21.8 6.6e-28 97.8 7.5 2.0 2 0 0 2 2 2 2 Outer membrane efflux protein HemolysinCabind PF00353.19 CAV18557.1 - 4.1e-14 52.2 62.8 3.4e-08 33.3 20.3 5.2 5 0 0 5 5 5 2 RTX calcium-binding nonapeptide repeat (4 copies) Calx-beta PF03160.14 CAV18557.1 - 7.1e-14 51.8 45.3 0.027 14.6 1.8 12.4 9 5 0 9 9 9 6 Calx-beta domain VWA_2 PF13519.6 CAV18557.1 - 1.7e-12 47.9 0.2 5e-12 46.4 0.2 1.9 1 0 0 1 1 1 1 von Willebrand factor type A domain DUF2745 PF10922.8 CAV18557.1 - 6.1e-06 26.4 3.3 19 5.6 0.0 5.6 5 1 1 6 6 6 0 Protein of unknown function (DUF2745) VWA_CoxE PF05762.14 CAV18557.1 - 6.5e-05 22.4 0.0 0.00012 21.5 0.0 1.3 1 0 0 1 1 1 1 VWA domain containing CoxE-like protein RNase_PH PF01138.21 CAV18557.1 - 8.8e-05 23.0 11.4 4.1 7.9 0.1 5.7 5 0 0 5 5 5 2 3' exoribonuclease family, domain 1 Glyco_hydro_2_N PF02837.18 CAV18557.1 - 0.0068 16.3 3.3 25 4.7 0.0 4.3 4 0 0 4 4 4 0 Glycosyl hydrolases family 2, sugar binding domain CotE PF10628.9 CAV18557.1 - 0.008 15.8 0.1 0.008 15.8 0.1 4.4 5 0 0 5 5 5 1 Outer spore coat protein E (CotE) DUF2271 PF10029.9 CAV18557.1 - 0.11 12.1 15.6 7.1 6.3 0.1 5.3 5 0 0 5 5 5 0 Predicted periplasmic protein (DUF2271) DUF896 PF05979.12 CAV18557.1 - 8.8 6.3 6.3 1e+02 2.9 0.1 3.7 4 0 0 4 4 4 0 Bacterial protein of unknown function (DUF896) Methyltrans_SAM PF10672.9 CAV18558.1 - 7.6e-28 97.5 0.0 1e-27 97.1 0.0 1.1 1 0 0 1 1 1 1 S-adenosylmethionine-dependent methyltransferase PUA_3 PF17785.1 CAV18558.1 - 1.5e-20 72.7 0.1 2.8e-20 71.9 0.1 1.5 1 0 0 1 1 1 1 PUA-like domain Cons_hypoth95 PF03602.15 CAV18558.1 - 1.6e-07 31.2 0.0 2.7e-07 30.4 0.0 1.3 1 0 0 1 1 1 1 Conserved hypothetical protein 95 Methyltransf_31 PF13847.6 CAV18558.1 - 8.4e-07 28.9 0.1 1.5e-06 28.1 0.1 1.4 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 CAV18558.1 - 0.00072 19.1 0.0 0.0011 18.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_15 PF09445.10 CAV18558.1 - 0.001 18.7 0.0 0.0016 18.0 0.0 1.3 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase TRM PF02005.16 CAV18558.1 - 0.0077 15.5 0.1 0.01 15.0 0.1 1.1 1 0 0 1 1 1 1 N2,N2-dimethylguanosine tRNA methyltransferase PUA PF01472.20 CAV18558.1 - 0.009 16.0 0.0 0.03 14.3 0.0 1.9 2 0 0 2 2 2 1 PUA domain PrmA PF06325.13 CAV18558.1 - 0.016 14.6 0.0 0.026 13.9 0.0 1.3 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_25 PF13649.6 CAV18558.1 - 0.044 14.5 0.0 0.098 13.4 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain 2_5_RNA_ligase2 PF13563.6 CAV18558.1 - 0.16 11.9 0.0 0.29 11.0 0.0 1.4 1 0 0 1 1 1 0 2'-5' RNA ligase superfamily MCPsignal PF00015.21 CAV18559.1 - 1e-39 136.1 45.8 6.6e-39 133.5 28.9 2.6 1 1 1 2 2 2 2 Methyl-accepting chemotaxis protein (MCP) signalling domain AIP3 PF03915.13 CAV18559.1 - 0.0002 20.6 19.7 0.0003 20.0 19.7 1.2 1 0 0 1 1 1 1 Actin interacting protein 3 BSP_II PF05432.11 CAV18559.1 - 0.18 11.5 8.7 0.14 11.8 7.2 1.4 1 1 0 1 1 1 0 Bone sialoprotein II (BSP-II) HAMP PF00672.25 CAV18559.1 - 0.35 11.3 0.0 0.35 11.3 0.0 4.2 6 1 0 6 6 4 0 HAMP domain Pox_Rap94 PF03294.14 CAV18559.1 - 0.84 7.7 7.2 2.9 5.9 2.0 2.2 2 0 0 2 2 2 0 RNA polymerase-associated transcription specificity factor, Rap94 Spc7 PF08317.11 CAV18559.1 - 1.2 7.9 26.8 1.6 7.5 10.8 2.3 1 1 0 2 2 2 0 Spc7 kinetochore protein T7SS_ESX_EspC PF10824.8 CAV18559.1 - 1.6 9.2 27.8 3.1 8.3 2.2 4.9 1 1 3 5 5 5 0 Excreted virulence factor EspC, type VII ESX diderm ING PF12998.7 CAV18559.1 - 2 9.0 11.2 3.2 8.4 0.0 3.7 3 1 0 3 3 3 0 Inhibitor of growth proteins N-terminal histone-binding DHR10 PF18595.1 CAV18559.1 - 2.7 8.1 25.3 2.3 8.3 0.9 4.3 3 1 0 3 3 3 0 Designed helical repeat protein 10 domain DUF948 PF06103.11 CAV18559.1 - 4.4 7.6 35.3 2.1 8.7 3.9 5.9 3 2 2 5 5 5 0 Bacterial protein of unknown function (DUF948) Tup_N PF08581.10 CAV18559.1 - 4.6 7.6 13.7 13 6.1 2.5 4.2 4 0 0 4 4 4 0 Tup N-terminal BLOC1_2 PF10046.9 CAV18559.1 - 6.6 7.1 28.0 0.59 10.5 2.3 4.4 2 2 2 4 4 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 GAT PF03127.14 CAV18559.1 - 8.4 6.8 15.0 4.8 7.6 1.0 4.0 2 1 1 3 3 3 0 GAT domain DUF1664 PF07889.12 CAV18559.1 - 9.5 6.3 29.5 10 6.1 3.2 4.5 2 2 1 4 4 4 0 Protein of unknown function (DUF1664) Acylphosphatase PF00708.18 CAV18560.1 - 7.9e-23 80.7 0.2 8.4e-23 80.6 0.2 1.0 1 0 0 1 1 1 1 Acylphosphatase DsrC PF04358.13 CAV18561.1 - 6.6e-43 145.6 0.1 7.4e-43 145.4 0.1 1.0 1 0 0 1 1 1 1 DsrC like protein 2Fe-2S_thioredx PF01257.19 CAV18561.1 - 0.018 14.9 0.0 0.02 14.8 0.0 1.1 1 0 0 1 1 1 0 Thioredoxin-like [2Fe-2S] ferredoxin Bax1-I PF01027.20 CAV18562.1 - 1.3e-41 142.7 32.8 1.5e-41 142.5 32.8 1.0 1 0 0 1 1 1 1 Inhibitor of apoptosis-promoting Bax1 Meckelin PF09773.9 CAV18562.1 - 2.3 6.2 3.9 3 5.8 3.9 1.2 1 0 0 1 1 1 0 Meckelin (Transmembrane protein 67) DUF4191 PF13829.6 CAV18562.1 - 9.9 5.4 9.8 4.8 6.5 4.0 2.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4191) ABC_tran PF00005.27 CAV18563.1 - 8.4e-39 133.2 0.0 1.2e-38 132.7 0.0 1.2 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 CAV18563.1 - 9.2e-10 38.8 0.0 2.2e-05 24.5 0.0 2.1 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 CAV18563.1 - 2.9e-07 30.2 0.2 0.00017 21.1 0.2 2.1 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 CAV18563.1 - 8.9e-05 22.2 0.0 0.00017 21.2 0.0 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain ATPase_2 PF01637.18 CAV18563.1 - 0.00017 21.6 0.0 0.00056 19.9 0.0 1.9 2 0 0 2 2 2 1 ATPase domain predominantly from Archaea AAA_15 PF13175.6 CAV18563.1 - 0.00042 20.2 0.0 0.012 15.4 0.0 2.1 1 1 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 CAV18563.1 - 0.00047 20.4 0.0 0.0014 18.9 0.0 1.8 2 0 0 2 2 2 1 AAA domain AAA_23 PF13476.6 CAV18563.1 - 0.00058 20.4 0.0 0.001 19.6 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 CAV18563.1 - 0.0008 19.8 0.0 0.00096 19.6 0.0 1.4 1 1 0 1 1 1 1 AAA ATPase domain RsgA_GTPase PF03193.16 CAV18563.1 - 0.00095 19.1 0.0 0.0016 18.3 0.0 1.4 1 0 0 1 1 1 1 RsgA GTPase Rad17 PF03215.15 CAV18563.1 - 0.0011 19.0 0.0 0.0033 17.4 0.0 1.9 2 0 0 2 2 2 1 Rad17 P-loop domain AAA_18 PF13238.6 CAV18563.1 - 0.0043 17.6 0.0 0.011 16.3 0.0 1.7 2 0 0 2 2 1 1 AAA domain AAA PF00004.29 CAV18563.1 - 0.0065 16.9 0.1 0.59 10.6 0.0 2.8 1 1 1 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_33 PF13671.6 CAV18563.1 - 0.0082 16.3 0.0 0.013 15.7 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 CAV18563.1 - 0.009 15.7 0.0 0.018 14.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain G-alpha PF00503.20 CAV18563.1 - 0.0098 15.1 0.0 0.01 15.0 0.0 1.3 1 0 0 1 1 1 1 G-protein alpha subunit Sigma54_activat PF00158.26 CAV18563.1 - 0.013 15.2 0.0 0.05 13.3 0.0 1.8 2 0 0 2 2 2 0 Sigma-54 interaction domain RNA_helicase PF00910.22 CAV18563.1 - 0.013 15.8 0.0 0.066 13.6 0.0 2.1 2 0 0 2 2 2 0 RNA helicase IstB_IS21 PF01695.17 CAV18563.1 - 0.014 15.1 0.0 0.032 14.0 0.0 1.6 2 0 0 2 2 2 0 IstB-like ATP binding protein TniB PF05621.11 CAV18563.1 - 0.016 14.7 0.1 4.9 6.5 0.0 2.6 3 0 0 3 3 3 0 Bacterial TniB protein AAA_13 PF13166.6 CAV18563.1 - 0.016 13.9 0.0 2.8 6.5 0.0 2.1 2 0 0 2 2 2 0 AAA domain T2SSE PF00437.20 CAV18563.1 - 0.016 14.3 0.0 0.04 13.0 0.0 1.7 2 0 0 2 2 2 0 Type II/IV secretion system protein AAA_7 PF12775.7 CAV18563.1 - 0.018 14.6 0.0 0.038 13.5 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region FtsK_SpoIIIE PF01580.18 CAV18563.1 - 0.018 14.4 0.4 0.064 12.6 0.0 1.9 2 0 0 2 2 2 0 FtsK/SpoIIIE family AAA_24 PF13479.6 CAV18563.1 - 0.018 14.8 0.0 0.049 13.3 0.0 1.8 2 0 0 2 2 2 0 AAA domain ABC_ATPase PF09818.9 CAV18563.1 - 0.019 13.8 0.0 2 7.1 0.0 2.7 2 1 0 2 2 2 0 Predicted ATPase of the ABC class SbcCD_C PF13558.6 CAV18563.1 - 0.044 14.0 0.4 0.56 10.5 0.4 2.2 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit cobW PF02492.19 CAV18563.1 - 0.044 13.4 0.0 0.083 12.5 0.0 1.4 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain ATPase PF06745.13 CAV18563.1 - 0.045 13.1 0.0 0.15 11.4 0.0 1.8 2 0 0 2 2 2 0 KaiC DAP3 PF10236.9 CAV18563.1 - 0.045 12.9 0.0 0.89 8.7 0.1 2.1 2 0 0 2 2 2 0 Mitochondrial ribosomal death-associated protein 3 AAA_28 PF13521.6 CAV18563.1 - 0.046 14.0 0.0 0.13 12.5 0.0 1.8 2 0 0 2 2 2 0 AAA domain Mg_chelatase PF01078.21 CAV18563.1 - 0.048 13.0 0.0 0.12 11.7 0.0 1.6 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI Viral_helicase1 PF01443.18 CAV18563.1 - 0.093 12.5 0.0 0.15 11.8 0.0 1.3 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase DEAD PF00270.29 CAV18563.1 - 0.1 12.4 0.0 0.13 12.0 0.0 1.2 1 0 0 1 1 1 0 DEAD/DEAH box helicase Roc PF08477.13 CAV18563.1 - 0.12 12.6 0.0 0.24 11.6 0.0 1.5 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase PRK PF00485.18 CAV18563.1 - 0.15 11.8 0.0 0.25 11.0 0.0 1.4 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family BPD_transp_1 PF00528.22 CAV18564.1 - 1e-22 80.8 8.5 1e-22 80.8 8.5 2.5 2 1 1 3 3 3 1 Binding-protein-dependent transport system inner membrane component DUF5379 PF17350.2 CAV18564.1 - 0.00021 21.5 9.5 0.00057 20.1 0.9 3.1 2 0 0 2 2 2 2 Family of unknown function (DUF5379) BPD_transp_1 PF00528.22 CAV18565.1 - 1.5e-10 41.1 37.0 2.6e-10 40.3 27.6 3.6 1 1 2 3 3 3 1 Binding-protein-dependent transport system inner membrane component DUF1980 PF09323.10 CAV18565.1 - 0.058 13.3 0.4 0.058 13.3 0.4 2.4 3 0 0 3 3 3 0 Domain of unknown function (DUF1980) UcrQ PF02939.16 CAV18565.1 - 0.093 12.7 0.6 0.74 9.8 0.1 2.6 2 0 0 2 2 2 0 UcrQ family UL42 PF17638.2 CAV18565.1 - 0.65 10.0 2.3 3.4 7.7 0.0 2.8 3 0 0 3 3 3 0 HCMV UL42 SBP_bac_3 PF00497.20 CAV18566.1 - 1.8e-29 102.8 0.0 2.4e-29 102.4 0.0 1.1 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 NMT1 PF09084.11 CAV18566.1 - 0.00015 21.8 0.0 0.048 13.6 0.0 2.3 1 1 1 2 2 2 2 NMT1/THI5 like NAD_binding_7 PF13241.6 CAV18567.1 - 1.6e-28 99.2 0.0 3.5e-28 98.1 0.0 1.6 1 0 0 1 1 1 1 Putative NAD(P)-binding CysG_dimeriser PF10414.9 CAV18567.1 - 1.1e-13 50.6 0.0 2e-13 49.8 0.0 1.5 1 0 0 1 1 1 1 Sirohaem synthase dimerisation region Sirohm_synth_M PF14824.6 CAV18567.1 - 3.1e-09 36.1 0.6 6.7e-09 35.0 0.6 1.6 1 0 0 1 1 1 1 Sirohaem biosynthesis protein central Pyr_redox_3 PF13738.6 CAV18567.1 - 0.013 14.7 0.0 0.024 13.9 0.0 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 CAV18567.1 - 0.038 14.5 0.0 0.084 13.4 0.0 1.6 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase DUF520 PF04461.13 CAV18568.1 - 1.3e-64 217.2 6.2 1.4e-64 217.0 6.2 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF520) PHA_gran_rgn PF09650.10 CAV18568.1 - 0.0017 18.6 0.6 0.048 13.9 0.0 2.3 2 1 0 2 2 2 1 Putative polyhydroxyalkanoic acid system protein (PHA_gran_rgn) DUF3071 PF11268.8 CAV18568.1 - 0.0058 16.7 0.1 0.01 15.9 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3071) YqbF PF14553.6 CAV18568.1 - 0.023 14.6 0.2 0.046 13.6 0.2 1.5 1 0 0 1 1 1 0 YqbF, hypothetical protein domain Nrap_D5 PF17406.2 CAV18568.1 - 0.16 11.7 0.4 0.22 11.3 0.4 1.1 1 0 0 1 1 1 0 Nrap protein PAP/OAS1-like domain 5 DinI PF06183.13 CAV18568.1 - 0.24 11.8 2.2 0.45 10.9 0.4 2.3 3 0 0 3 3 3 0 DinI-like family DAHP_synth_1 PF00793.20 CAV18569.1 - 2.1e-98 328.6 0.0 2.6e-98 328.3 0.0 1.0 1 0 0 1 1 1 1 DAHP synthetase I family PEP-utilizers_C PF02896.18 CAV18570.1 - 1.8e-15 56.8 0.0 2.4e-15 56.4 0.0 1.1 1 0 0 1 1 1 1 PEP-utilising enzyme, TIM barrel domain DUF4442 PF14539.6 CAV18571.1 - 7.5e-08 32.6 0.0 9.1e-08 32.3 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4442) S1_2 PF13509.6 CAV18573.1 - 5.2e-30 103.3 0.2 1.7e-22 79.2 0.1 2.4 2 0 0 2 2 2 2 S1 domain CvfB_WH PF17783.1 CAV18573.1 - 6.2e-22 77.2 0.3 1.1e-21 76.3 0.3 1.5 1 0 0 1 1 1 1 CvfB-like winged helix domain S1 PF00575.23 CAV18573.1 - 0.035 14.5 0.5 8.6 6.8 0.0 3.3 3 0 0 3 3 3 0 S1 RNA binding domain Methyltr_RsmB-F PF01189.17 CAV18574.1 - 8.4e-49 165.9 0.0 1.6e-48 165.0 0.0 1.4 1 0 0 1 1 1 1 16S rRNA methyltransferase RsmB/F Methyltr_RsmF_N PF17125.5 CAV18574.1 - 1.1e-28 99.6 0.0 2.5e-28 98.4 0.0 1.6 1 0 0 1 1 1 1 N-terminal domain of 16S rRNA methyltransferase RsmF Methyltranf_PUA PF13636.6 CAV18574.1 - 1.9e-11 43.8 0.8 3.6e-11 42.9 0.8 1.5 1 0 0 1 1 1 1 RNA-binding PUA-like domain of methyltransferase RsmF FtsJ PF01728.19 CAV18574.1 - 7.9e-05 22.8 0.0 0.00012 22.2 0.0 1.3 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_31 PF13847.6 CAV18574.1 - 9.3e-05 22.3 0.0 0.00017 21.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain MlaD PF02470.20 CAV18575.1 - 1.9e-57 191.5 11.6 5.1e-13 49.1 0.0 7.4 7 0 0 7 7 7 7 MlaD protein Big_1 PF02369.16 CAV18575.1 - 0.0041 17.1 1.0 0.55 10.3 0.1 3.6 3 0 0 3 3 3 1 Bacterial Ig-like domain (group 1) MreC PF04085.14 CAV18575.1 - 0.04 13.8 6.2 41 4.1 0.2 5.5 7 0 0 7 7 7 0 rod shape-determining protein MreC GCV_T_C PF08669.11 CAV18575.1 - 0.084 12.8 0.2 11 6.1 0.0 4.1 5 0 0 5 5 5 0 Glycine cleavage T-protein C-terminal barrel domain PqiA PF04403.13 CAV18576.1 - 1.4e-82 275.1 31.0 2.1e-46 157.6 11.1 2.0 2 0 0 2 2 2 2 Paraquat-inducible protein A zf-CHY PF05495.12 CAV18576.1 - 0.22 12.1 7.7 0.59 10.7 0.9 2.3 2 0 0 2 2 2 0 CHY zinc finger DZR PF12773.7 CAV18576.1 - 0.74 9.9 10.7 2.6 8.2 2.3 2.8 2 1 0 2 2 2 0 Double zinc ribbon zinc-ribbons_6 PF07191.12 CAV18576.1 - 4.5 7.3 10.3 6.6 6.8 1.2 2.7 2 1 0 2 2 2 0 zinc-ribbons ABC_tran PF00005.27 CAV18577.1 - 9.8e-32 110.3 0.1 1.8e-31 109.5 0.1 1.5 1 0 0 1 1 1 1 ABC transporter ABC_membrane PF00664.23 CAV18577.1 - 3.6e-29 102.3 11.2 4.9e-29 101.8 11.2 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region SMC_N PF02463.19 CAV18577.1 - 5.9e-06 25.9 0.0 0.00012 21.6 0.2 1.9 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain DEAD PF00270.29 CAV18577.1 - 0.00013 21.8 0.1 0.00029 20.7 0.1 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase RsgA_GTPase PF03193.16 CAV18577.1 - 0.0007 19.5 0.1 0.0022 17.9 0.0 1.8 2 0 0 2 2 2 1 RsgA GTPase AAA_16 PF13191.6 CAV18577.1 - 0.0044 17.4 0.4 0.014 15.8 0.2 2.0 2 0 0 2 2 2 1 AAA ATPase domain AAA_25 PF13481.6 CAV18577.1 - 0.0076 15.8 0.1 0.11 12.0 0.0 2.3 2 0 0 2 2 2 1 AAA domain MMR_HSR1 PF01926.23 CAV18577.1 - 0.0082 16.2 0.0 0.027 14.6 0.0 1.9 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_29 PF13555.6 CAV18577.1 - 0.0098 15.6 0.1 0.021 14.5 0.1 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain DLIC PF05783.11 CAV18577.1 - 0.015 14.2 0.0 0.021 13.7 0.0 1.1 1 0 0 1 1 1 0 Dynein light intermediate chain (DLIC) AAA_22 PF13401.6 CAV18577.1 - 0.018 15.3 0.3 0.2 11.9 0.3 2.4 1 1 0 1 1 1 0 AAA domain AAA_21 PF13304.6 CAV18577.1 - 0.019 14.7 0.1 0.063 13.1 0.0 1.9 2 0 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system ABC_membrane_3 PF13748.6 CAV18577.1 - 0.038 13.2 15.2 0.03 13.6 5.9 3.3 2 1 0 2 2 2 0 ABC transporter transmembrane region DUF815 PF05673.13 CAV18577.1 - 0.05 12.8 0.0 0.093 11.9 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_7 PF12775.7 CAV18577.1 - 0.069 12.7 0.0 0.21 11.1 0.0 1.8 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_28 PF13521.6 CAV18577.1 - 0.11 12.7 0.0 0.25 11.6 0.0 1.6 1 0 0 1 1 1 0 AAA domain SbcCD_C PF13558.6 CAV18577.1 - 0.51 10.6 2.8 1.5 9.1 0.3 2.9 2 1 0 2 2 2 0 Putative exonuclease SbcCD, C subunit GAF_2 PF13185.6 CAV18578.1 - 1.4e-09 38.4 0.0 1.6e-09 38.2 0.0 1.1 1 0 0 1 1 1 1 GAF domain GAF PF01590.26 CAV18578.1 - 0.00012 22.7 0.0 0.00015 22.4 0.0 1.2 1 0 0 1 1 1 1 GAF domain Semialdhyde_dhC PF02774.18 CAV18578.1 - 0.11 12.6 0.0 0.14 12.3 0.0 1.2 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, dimerisation domain ProQ PF04352.13 CAV18579.1 - 5.5e-43 145.3 0.3 5.5e-43 145.3 0.3 2.0 1 1 1 2 2 2 1 ProQ/FINO family ProQ_C PF17516.2 CAV18579.1 - 6.2e-21 73.6 1.0 1.1e-20 72.8 1.0 1.4 1 0 0 1 1 1 1 ProQ C-terminal domain MRP-S26 PF14943.6 CAV18579.1 - 0.00021 21.2 6.4 0.00031 20.7 6.4 1.2 1 0 0 1 1 1 1 Mitochondrial ribosome subunit S26 Myosin_N PF02736.19 CAV18579.1 - 0.02 14.7 0.3 0.062 13.1 0.0 2.0 2 0 0 2 2 2 0 Myosin N-terminal SH3-like domain MCM_bind PF09739.9 CAV18579.1 - 0.037 12.5 0.8 0.045 12.2 0.8 1.1 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor Spc7 PF08317.11 CAV18579.1 - 0.25 10.2 5.3 0.3 9.9 5.3 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein TSP_NTD PF17804.1 CAV18580.1 - 2.2e-58 197.7 12.1 2.2e-58 197.7 12.1 1.9 2 0 0 2 2 2 1 Tail specific protease N-terminal domain Peptidase_S41 PF03572.18 CAV18580.1 - 1.6e-52 177.4 0.6 2.8e-52 176.6 0.6 1.4 1 0 0 1 1 1 1 Peptidase family S41 DUF3340 PF11818.8 CAV18580.1 - 2e-37 128.7 7.5 2e-37 128.7 7.5 2.0 2 0 0 2 2 2 1 C-terminal domain of tail specific protease (DUF3340) BAGE PF08180.11 CAV18580.1 - 5.4e-14 52.0 6.6 9.7e-14 51.2 6.6 1.4 1 0 0 1 1 1 1 B melanoma antigen family PDZ PF00595.24 CAV18580.1 - 4.5e-13 49.3 0.7 9.3e-13 48.3 0.7 1.6 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 CAV18580.1 - 8.7e-05 22.8 1.6 0.00023 21.4 1.6 1.8 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 CAV18580.1 - 0.00081 19.2 2.3 0.0035 17.2 2.3 2.1 1 1 0 1 1 1 1 PDZ domain RTX_C PF08339.10 CAV18580.1 - 0.5 10.4 3.5 5.7 7.0 0.3 3.2 3 0 0 3 3 3 0 RTX C-terminal domain DUF5640 PF18692.1 CAV18581.1 - 0.00049 20.1 1.3 0.79 9.8 0.0 2.8 3 1 0 3 3 3 2 Family of unknown function (DUF5640) NlpE PF04170.12 CAV18581.1 - 0.0013 19.6 0.2 0.23 12.4 0.1 2.2 2 0 0 2 2 2 2 NlpE N-terminal domain DUF3458_C PF17432.2 CAV18582.1 - 4.6e-111 371.2 5.2 6.6e-111 370.7 5.2 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3458_C) ARM repeats Peptidase_M1 PF01433.20 CAV18582.1 - 1.7e-54 184.6 1.4 2.5e-54 184.1 0.4 1.7 2 0 0 2 2 2 1 Peptidase family M1 domain DUF3458 PF11940.8 CAV18582.1 - 1.7e-32 111.7 1.0 3.7e-32 110.6 0.3 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF3458) Ig-like fold Peptidase_M1_N PF17900.1 CAV18582.1 - 7.6e-17 62.1 0.0 2.2e-16 60.6 0.0 1.8 1 0 0 1 1 1 1 Peptidase M1 N-terminal domain Ovate PF04844.13 CAV18582.1 - 0.046 13.7 0.1 4.5 7.3 0.0 2.8 2 0 0 2 2 2 0 Transcriptional repressor, ovate DUF2835 PF11197.8 CAV18583.1 - 1.3e-29 101.8 0.3 1.4e-29 101.7 0.3 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2835) Bac_GDH PF05088.12 CAV18584.1 - 0 2195.8 0.8 0 2195.8 0.8 1.5 2 0 0 2 2 2 1 Bacterial NAD-glutamate dehydrogenase Holin_BhlA PF10960.8 CAV18584.1 - 0.11 12.5 1.1 0.32 11.0 0.1 2.4 2 0 0 2 2 2 0 BhlA holin family DHO_dh PF01180.21 CAV18585.1 - 1.7e-89 300.0 0.2 2e-89 299.7 0.2 1.0 1 0 0 1 1 1 1 Dihydroorotate dehydrogenase ZapC PF07126.12 CAV18586.1 - 2.5e-65 219.2 0.0 2.7e-65 219.0 0.0 1.0 1 0 0 1 1 1 1 Cell-division protein ZapC UPF0020 PF01170.18 CAV18587.1 - 9.2e-69 231.1 0.2 5.8e-63 212.1 0.0 2.5 3 0 0 3 3 3 2 Putative RNA methylase family UPF0020 Methyltrans_SAM PF10672.9 CAV18587.1 - 1.2e-28 100.1 0.3 1.9e-28 99.4 0.3 1.2 1 0 0 1 1 1 1 S-adenosylmethionine-dependent methyltransferase Cons_hypoth95 PF03602.15 CAV18587.1 - 1.2e-16 60.8 0.0 5.7e-11 42.4 0.0 3.4 2 1 1 3 3 3 2 Conserved hypothetical protein 95 Methyltransf_25 PF13649.6 CAV18587.1 - 6.4e-15 55.6 0.1 1.3e-05 25.8 0.0 4.1 4 0 0 4 4 4 2 Methyltransferase domain THUMP PF02926.17 CAV18587.1 - 3e-13 50.1 0.2 1.6e-12 47.7 0.0 2.3 3 0 0 3 3 3 1 THUMP domain Methyltransf_31 PF13847.6 CAV18587.1 - 4.1e-13 49.4 0.3 0.00031 20.6 0.0 3.6 4 0 0 4 4 4 2 Methyltransferase domain Methyltransf_11 PF08241.12 CAV18587.1 - 5.9e-11 42.9 0.6 0.00054 20.6 0.0 3.8 4 0 0 4 4 3 2 Methyltransferase domain Methyltransf_15 PF09445.10 CAV18587.1 - 5.3e-07 29.3 0.0 0.025 14.2 0.0 2.9 3 0 0 3 3 3 2 RNA cap guanine-N2 methyltransferase PrmA PF06325.13 CAV18587.1 - 1.4e-05 24.7 0.0 0.62 9.4 0.0 3.7 4 0 0 4 4 4 2 Ribosomal protein L11 methyltransferase (PrmA) Ubie_methyltran PF01209.18 CAV18587.1 - 0.00017 21.0 0.1 0.74 9.1 0.0 3.2 2 1 0 3 3 3 2 ubiE/COQ5 methyltransferase family Methyltransf_3 PF01596.17 CAV18587.1 - 0.019 14.1 0.0 4.5 6.4 0.0 2.3 2 0 0 2 2 2 0 O-methyltransferase Methyltransf_18 PF12847.7 CAV18587.1 - 0.028 14.3 0.0 1.5 8.7 0.0 2.5 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_24 PF13578.6 CAV18587.1 - 0.032 15.3 0.0 0.5 11.4 0.0 2.5 2 0 0 2 2 2 0 Methyltransferase domain N6_Mtase PF02384.16 CAV18587.1 - 0.047 13.0 0.0 0.18 11.1 0.0 1.9 1 1 0 1 1 1 0 N-6 DNA Methylase N6_N4_Mtase PF01555.18 CAV18587.1 - 0.081 12.6 0.0 3.7 7.2 0.0 2.5 2 0 0 2 2 2 0 DNA methylase DUF836 PF05768.14 CAV18588.1 - 8.9e-19 67.7 0.0 9.9e-19 67.5 0.0 1.0 1 0 0 1 1 1 1 Glutaredoxin-like domain (DUF836) Glutaredoxin PF00462.24 CAV18588.1 - 0.0031 17.7 0.0 0.0064 16.7 0.0 1.5 2 0 0 2 2 2 1 Glutaredoxin DUF1223 PF06764.11 CAV18588.1 - 0.078 13.0 0.0 0.093 12.8 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1223) ABC_tran PF00005.27 CAV18589.1 - 3.6e-52 176.5 0.3 3.1e-24 86.0 0.0 3.8 3 1 0 3 3 3 2 ABC transporter ABC_tran_CTD PF16326.5 CAV18589.1 - 1.4e-20 73.3 9.7 1.4e-20 73.3 9.7 2.5 2 0 0 2 2 1 1 ABC transporter C-terminal domain AAA_21 PF13304.6 CAV18589.1 - 2.3e-18 67.0 16.2 3.8e-06 26.9 0.0 4.8 3 2 1 5 5 5 4 AAA domain, putative AbiEii toxin, Type IV TA system ABC_tran_Xtn PF12848.7 CAV18589.1 - 8.4e-11 41.8 2.4 8.4e-11 41.8 2.4 2.9 2 1 1 3 3 2 1 ABC transporter SMC_N PF02463.19 CAV18589.1 - 3.4e-10 39.7 0.4 0.086 12.3 0.0 4.1 3 1 0 3 3 3 3 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 CAV18589.1 - 3.8e-09 37.2 0.2 8.3e-05 23.0 0.0 2.7 2 0 0 2 2 2 2 AAA ATPase domain MMR_HSR1 PF01926.23 CAV18589.1 - 4.3e-08 33.2 0.0 0.00011 22.3 0.0 2.6 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_15 PF13175.6 CAV18589.1 - 1.8e-07 31.2 2.9 0.021 14.5 1.6 3.4 2 1 0 2 2 2 2 AAA ATPase domain AAA_29 PF13555.6 CAV18589.1 - 2.2e-07 30.5 0.0 0.018 14.8 0.0 2.4 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_22 PF13401.6 CAV18589.1 - 3.9e-07 30.4 9.8 5.2e-05 23.5 0.1 4.6 4 2 0 4 4 3 2 AAA domain RNA_helicase PF00910.22 CAV18589.1 - 8e-07 29.4 0.0 0.019 15.3 0.0 2.8 3 0 0 3 3 2 2 RNA helicase RsgA_GTPase PF03193.16 CAV18589.1 - 2.2e-06 27.6 0.0 0.035 14.0 0.0 2.5 2 0 0 2 2 2 2 RsgA GTPase NACHT PF05729.12 CAV18589.1 - 1.2e-05 25.3 0.2 0.1 12.5 0.2 2.7 2 1 0 2 2 2 2 NACHT domain Rad17 PF03215.15 CAV18589.1 - 2.9e-05 24.1 0.1 0.03 14.2 0.0 3.1 3 0 0 3 3 3 1 Rad17 P-loop domain AAA_28 PF13521.6 CAV18589.1 - 4.6e-05 23.7 0.0 0.29 11.4 0.0 3.1 2 1 0 2 2 2 2 AAA domain Dynamin_N PF00350.23 CAV18589.1 - 5e-05 23.4 0.0 0.071 13.2 0.0 2.9 2 0 0 2 2 2 1 Dynamin family AAA_5 PF07728.14 CAV18589.1 - 6e-05 23.1 0.0 0.68 9.9 0.0 3.3 3 0 0 3 3 3 2 AAA domain (dynein-related subfamily) AAA_18 PF13238.6 CAV18589.1 - 9.1e-05 23.0 2.0 0.17 12.4 0.0 3.4 3 1 0 3 3 3 1 AAA domain AAA_33 PF13671.6 CAV18589.1 - 0.00012 22.3 0.0 0.36 11.0 0.0 2.8 2 0 0 2 2 2 2 AAA domain AAA_24 PF13479.6 CAV18589.1 - 0.00017 21.4 0.0 0.72 9.5 0.0 2.8 3 0 0 3 3 2 2 AAA domain AAA PF00004.29 CAV18589.1 - 0.00019 21.9 0.0 0.17 12.3 0.0 3.2 3 0 0 3 3 2 1 ATPase family associated with various cellular activities (AAA) AAA_7 PF12775.7 CAV18589.1 - 0.0002 20.9 0.0 0.44 10.1 0.0 2.3 2 0 0 2 2 2 2 P-loop containing dynein motor region AAA_30 PF13604.6 CAV18589.1 - 0.0002 21.1 0.0 0.56 9.9 0.0 3.0 2 1 0 2 2 2 2 AAA domain MukB PF04310.12 CAV18589.1 - 0.0003 20.7 0.4 0.68 9.7 0.0 2.7 3 0 0 3 3 2 2 MukB N-terminal Zeta_toxin PF06414.12 CAV18589.1 - 0.00071 18.9 0.0 1.1 8.5 0.0 2.4 2 0 0 2 2 2 2 Zeta toxin ATP-synt_ab PF00006.25 CAV18589.1 - 0.00076 19.2 0.0 0.075 12.7 0.0 2.2 2 0 0 2 2 2 1 ATP synthase alpha/beta family, nucleotide-binding domain AAA_23 PF13476.6 CAV18589.1 - 0.00093 19.8 19.0 0.14 12.6 0.0 4.4 4 1 0 5 5 3 2 AAA domain AAA_25 PF13481.6 CAV18589.1 - 0.0014 18.2 0.0 2 8.0 0.0 3.4 4 0 0 4 4 3 1 AAA domain DUF815 PF05673.13 CAV18589.1 - 0.0017 17.5 0.0 2.2 7.4 0.0 2.9 3 0 0 3 3 3 1 Protein of unknown function (DUF815) PduV-EutP PF10662.9 CAV18589.1 - 0.0017 18.1 0.1 0.47 10.2 0.0 2.4 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation TsaE PF02367.17 CAV18589.1 - 0.0019 18.2 0.0 3.3 7.7 0.0 3.1 3 0 0 3 3 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE Roc PF08477.13 CAV18589.1 - 0.0023 18.1 0.0 0.75 10.0 0.0 2.7 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase NB-ARC PF00931.22 CAV18589.1 - 0.0024 17.1 0.0 0.6 9.2 0.0 2.5 2 0 0 2 2 2 1 NB-ARC domain ATPase_2 PF01637.18 CAV18589.1 - 0.0041 17.1 2.1 0.85 9.5 0.0 3.5 2 1 1 3 3 3 1 ATPase domain predominantly from Archaea DUF87 PF01935.17 CAV18589.1 - 0.0056 16.8 3.1 2.1 8.3 0.0 3.6 4 0 0 4 4 3 1 Helicase HerA, central domain AAA_14 PF13173.6 CAV18589.1 - 0.006 16.6 0.0 1.4 9.0 0.0 3.4 3 0 0 3 3 3 1 AAA domain MeaB PF03308.16 CAV18589.1 - 0.0062 15.5 0.0 3 6.8 0.0 2.5 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_10 PF12846.7 CAV18589.1 - 0.0074 15.2 0.0 0.44 9.4 0.0 2.4 2 0 0 2 2 2 1 AAA-like domain IstB_IS21 PF01695.17 CAV18589.1 - 0.013 15.2 0.1 2.7 7.7 0.0 2.8 3 0 0 3 3 2 0 IstB-like ATP binding protein NTPase_1 PF03266.15 CAV18589.1 - 0.015 15.2 0.1 2.9 7.8 0.0 2.7 2 0 0 2 2 2 0 NTPase AAA_27 PF13514.6 CAV18589.1 - 0.018 14.7 0.1 6.5 6.3 0.0 2.9 3 0 0 3 3 2 0 AAA domain G-alpha PF00503.20 CAV18589.1 - 0.022 13.9 0.0 6 5.9 0.0 2.3 2 0 0 2 2 2 0 G-protein alpha subunit dNK PF01712.19 CAV18589.1 - 0.027 14.3 0.3 8.5 6.2 0.1 2.7 2 0 0 2 2 2 0 Deoxynucleoside kinase Ploopntkinase3 PF18751.1 CAV18589.1 - 0.036 14.0 0.2 1.5 8.7 0.0 2.9 3 0 0 3 3 3 0 P-loop Nucleotide Kinase3 Gtr1_RagA PF04670.12 CAV18589.1 - 0.045 13.1 0.1 1.4 8.2 0.1 2.3 2 0 0 2 2 2 0 Gtr1/RagA G protein conserved region Septin PF00735.18 CAV18589.1 - 0.09 12.0 0.0 3 7.1 0.0 2.3 2 0 0 2 2 2 0 Septin Arf PF00025.21 CAV18589.1 - 0.11 11.9 0.1 4.4 6.7 0.0 2.4 2 0 0 2 2 2 0 ADP-ribosylation factor family AAA_19 PF13245.6 CAV18589.1 - 0.13 12.6 1.0 5.4 7.3 0.3 3.3 3 1 0 3 3 2 0 AAA domain NurA PF09376.10 CAV18589.1 - 0.14 11.8 0.1 9.4 5.8 0.1 2.2 1 1 1 2 2 2 0 NurA domain CLP1_P PF16575.5 CAV18589.1 - 0.84 9.4 3.3 19 5.0 0.0 2.9 3 0 0 3 3 2 0 mRNA cleavage and polyadenylation factor CLP1 P-loop FapA PF03961.13 CAV18589.1 - 1.8 7.1 5.7 4.5 5.8 2.9 2.1 2 0 0 2 2 2 0 Flagellar Assembly Protein A DUF3466 PF11949.8 CAV18590.1 - 6e-68 229.9 15.4 3.7e-60 204.2 8.6 2.1 1 1 1 2 2 2 2 Protein of unknown function (DUF3466) SBBP PF06739.11 CAV18590.1 - 0.0029 17.6 1.5 0.012 15.6 1.5 2.1 1 0 0 1 1 1 1 Beta-propeller repeat DUF3285 PF11688.8 CAV18590.1 - 0.28 11.1 0.7 0.71 9.8 0.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3285) RMF PF04957.12 CAV18591.1 - 1.8e-27 95.3 7.2 2e-27 95.2 7.2 1.0 1 0 0 1 1 1 1 Ribosome modulation factor FabA PF07977.13 CAV18592.1 - 8.5e-55 184.2 0.0 9.9e-55 183.9 0.0 1.0 1 0 0 1 1 1 1 FabA-like domain AAA_32 PF13654.6 CAV18593.1 - 3.7e-26 92.0 0.0 5.8e-26 91.4 0.0 1.2 1 0 0 1 1 1 1 AAA domain Lon_C PF05362.13 CAV18593.1 - 2e-10 40.5 0.0 6.7e-10 38.9 0.0 1.8 2 0 0 2 2 2 1 Lon protease (S16) C-terminal proteolytic domain MatP PF06303.12 CAV18594.1 - 2.5e-44 149.7 1.1 2.5e-44 149.7 1.1 1.6 2 0 0 2 2 2 1 MatP N-terminal domain MatP_C PF17414.2 CAV18594.1 - 1.1e-27 95.9 3.2 2e-27 95.1 3.2 1.4 1 0 0 1 1 1 1 MatP C-terminal ribbon-helix-helix domain CcdA PF07362.12 CAV18594.1 - 0.0034 17.8 2.2 0.45 11.0 0.3 2.3 1 1 1 2 2 2 2 Post-segregation antitoxin CcdA ApoC-I PF04691.12 CAV18594.1 - 0.062 13.2 0.1 0.42 10.6 0.0 2.2 2 1 0 2 2 2 0 Apolipoprotein C-I (ApoC-1) DUF3634 PF12321.8 CAV18595.1 - 1e-40 138.2 0.2 1.1e-40 138.1 0.2 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3634) DUF2971 PF11185.8 CAV18597.1 - 2.3e-08 35.1 3.0 2.8e-08 34.8 0.6 2.3 2 1 0 2 2 2 1 Protein of unknown function (DUF2971) OMP_b-brl PF13505.6 CAV18598.1 - 1.2e-15 58.1 4.7 1.4e-15 57.9 4.7 1.0 1 0 0 1 1 1 1 Outer membrane protein beta-barrel domain Opacity PF02462.15 CAV18598.1 - 0.0014 18.8 0.2 1.6 8.8 0.0 2.2 2 0 0 2 2 2 2 Opacity family porin protein OprF PF05736.11 CAV18598.1 - 0.025 14.3 0.5 0.092 12.5 0.1 2.0 1 1 1 2 2 2 0 OprF membrane domain S1FA PF04689.13 CAV18599.1 - 0.24 11.5 0.2 0.24 11.5 0.2 1.8 1 1 1 2 2 2 0 DNA binding protein S1FA AgrD PF05931.11 CAV18600.1 - 0.051 13.6 0.9 1.4 9.0 0.3 2.1 2 0 0 2 2 2 0 Staphylococcal AgrD protein RSS_P20 PF11757.8 CAV18600.1 - 0.084 13.3 0.0 0.088 13.3 0.0 1.2 1 0 0 1 1 1 0 Suppressor of RNA silencing P21-like N-terminal domain DUF4062 PF13271.6 CAV18604.1 - 3e-27 94.8 0.1 6.3e-27 93.8 0.1 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4062) Csm1_N PF18504.1 CAV18604.1 - 0.056 13.8 0.1 0.13 12.6 0.1 1.6 1 0 0 1 1 1 0 Csm1 N-terminal domain GAF PF01590.26 CAV18605.1 - 0.11 13.2 0.0 0.16 12.6 0.0 1.3 1 0 0 1 1 1 0 GAF domain Phage_integrase PF00589.22 CAV18605.1 - 0.11 12.2 0.2 0.36 10.6 0.1 1.8 2 0 0 2 2 2 0 Phage integrase family DUF4065 PF13274.6 CAV18606.1 - 8.6e-16 58.8 0.2 1.2e-15 58.4 0.2 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF4065) NUDIX_5 PF16705.5 CAV18606.1 - 0.045 13.5 0.0 0.083 12.6 0.0 1.4 1 0 0 1 1 1 0 NUDIX, or N-terminal NPxY motif-rich, region of KRIT DUF1405 PF07187.11 CAV18606.1 - 0.15 12.1 0.2 0.84 9.6 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1405) ParE_toxin PF05016.15 CAV18607.1 - 2.8e-20 72.7 0.0 3.1e-20 72.6 0.0 1.0 1 0 0 1 1 1 1 ParE toxin of type II toxin-antitoxin system, parDE ParD_antitoxin PF03693.14 CAV18608.1 - 3.5e-37 126.7 0.3 3.7e-37 126.6 0.3 1.0 1 0 0 1 1 1 1 Bacterial antitoxin of ParD toxin-antitoxin type II system and RHH DUF2000 PF09391.10 CAV18608.1 - 0.072 13.0 0.0 0.072 13.0 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2000) HTH_28 PF13518.6 CAV18610.1 - 3.1e-06 27.2 1.9 0.00011 22.3 0.4 2.6 2 1 0 2 2 2 1 Helix-turn-helix domain HTH_29 PF13551.6 CAV18610.1 - 6.8e-06 26.0 0.9 1.3e-05 25.2 0.7 1.6 1 1 0 1 1 1 1 Winged helix-turn helix HTH_32 PF13565.6 CAV18610.1 - 4.7e-05 23.9 2.0 5.1e-05 23.8 0.4 1.9 2 0 0 2 2 2 1 Homeodomain-like domain HTH_23 PF13384.6 CAV18610.1 - 0.00016 21.4 2.3 0.0012 18.5 0.3 2.7 3 0 0 3 3 3 1 Homeodomain-like domain HTH_Tnp_1 PF01527.20 CAV18610.1 - 0.056 13.8 0.2 0.52 10.7 0.2 2.3 1 1 0 1 1 1 0 Transposase HBB PF06777.11 CAV18610.1 - 0.072 12.8 0.2 0.088 12.5 0.2 1.1 1 0 0 1 1 1 0 Helical and beta-bridge domain Cullin PF00888.22 CAV18610.1 - 0.11 11.1 0.1 0.13 10.9 0.1 1.0 1 0 0 1 1 1 0 Cullin family HTH_3 PF01381.22 CAV18613.1 - 4.7e-15 55.4 0.2 6.4e-15 55.0 0.2 1.2 1 0 0 1 1 1 1 Helix-turn-helix HTH_31 PF13560.6 CAV18613.1 - 8.5e-11 42.0 0.0 1.4e-10 41.4 0.0 1.2 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_19 PF12844.7 CAV18613.1 - 2.1e-10 40.5 0.0 2.9e-10 40.0 0.0 1.2 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_26 PF13443.6 CAV18613.1 - 7.5e-05 23.1 0.0 0.00012 22.4 0.0 1.3 1 0 0 1 1 1 1 Cro/C1-type HTH DNA-binding domain HTH_23 PF13384.6 CAV18613.1 - 0.0056 16.4 0.0 0.017 14.9 0.0 1.7 1 1 1 2 2 2 1 Homeodomain-like domain P22_Cro PF14549.6 CAV18613.1 - 0.0061 16.4 1.3 0.46 10.4 0.0 2.9 3 1 1 4 4 4 1 DNA-binding transcriptional regulator Cro HTH_Tnp_1_2 PF13022.6 CAV18613.1 - 0.0088 16.2 0.0 0.012 15.7 0.0 1.3 1 0 0 1 1 1 1 Helix-turn-helix of insertion element transposase YdaS_antitoxin PF15943.5 CAV18613.1 - 0.0093 15.8 0.0 2.4 8.1 0.0 2.2 1 1 1 2 2 2 2 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT HTH_10 PF04967.12 CAV18613.1 - 0.079 12.8 0.0 3.2 7.6 0.0 2.3 2 0 0 2 2 2 0 HTH DNA binding domain MqsA_antitoxin PF15731.5 CAV18613.1 - 0.1 12.7 0.0 0.15 12.2 0.0 1.2 1 0 0 1 1 1 0 Antitoxin component of bacterial toxin-antitoxin system, MqsA HTH_25 PF13413.6 CAV18613.1 - 0.19 11.6 0.1 0.78 9.7 0.1 2.0 1 1 0 1 1 1 0 Helix-turn-helix domain MerR PF00376.23 CAV18613.1 - 0.24 11.2 0.1 8 6.3 0.0 2.4 2 0 0 2 2 2 0 MerR family regulatory protein Phage_CRI PF05144.14 CAV18614.1 - 2.2e-05 23.9 0.0 2.7e-05 23.6 0.0 1.2 1 0 0 1 1 1 1 Phage replication protein CRI Phage_X PF05155.15 CAV18615.1 - 1.4e-35 121.6 0.1 2e-35 121.1 0.1 1.2 1 0 0 1 1 1 1 Phage X family Phage_DNA_bind PF02303.17 CAV18616.1 - 1e-36 125.0 0.0 1.2e-36 124.8 0.0 1.0 1 0 0 1 1 1 1 Helix-destabilising protein Rota_NSP3 PF01665.16 CAV18617.1 - 0.0036 16.5 1.4 0.0044 16.2 1.4 1.2 1 0 0 1 1 1 1 Rotavirus non-structural protein NSP3 rve PF00665.26 CAV18618.1 - 2.3e-06 27.8 0.0 4.9e-06 26.7 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain HTH_29 PF13551.6 CAV18618.1 - 2.9e-05 24.0 0.6 6.3e-05 22.9 0.6 1.6 1 0 0 1 1 1 1 Winged helix-turn helix HTH_28 PF13518.6 CAV18618.1 - 8.2e-05 22.6 1.1 0.0013 18.8 0.3 2.6 2 1 0 2 2 2 1 Helix-turn-helix domain HTH_32 PF13565.6 CAV18618.1 - 0.00031 21.3 0.1 0.00031 21.3 0.1 2.4 3 0 0 3 3 3 1 Homeodomain-like domain rve_3 PF13683.6 CAV18618.1 - 0.0011 18.7 0.0 0.0039 16.9 0.0 1.9 1 0 0 1 1 1 1 Integrase core domain HTH_23 PF13384.6 CAV18618.1 - 0.0016 18.2 2.2 0.0042 16.8 0.3 2.5 3 0 0 3 3 3 1 Homeodomain-like domain DUF4951 PF16309.5 CAV18618.1 - 0.081 13.0 2.2 1 9.4 0.9 2.6 2 0 0 2 2 2 0 Domian of unknown function (DUF4951) HATPase_c PF02518.26 CAV18619.1 - 6.6e-32 110.4 0.1 1.2e-31 109.5 0.1 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 CAV18619.1 - 5e-29 100.7 0.8 1e-28 99.7 0.8 1.6 1 0 0 1 1 1 1 Response regulator receiver domain HisKA PF00512.25 CAV18619.1 - 9.9e-17 60.7 0.2 3.6e-16 58.9 0.2 2.0 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain HATPase_c_3 PF13589.6 CAV18619.1 - 0.00016 21.5 0.0 0.00036 20.4 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_5 PF14501.6 CAV18619.1 - 0.012 15.5 0.0 0.037 13.9 0.0 1.9 1 0 0 1 1 1 0 GHKL domain HATPase_c_2 PF13581.6 CAV18619.1 - 0.013 15.5 0.0 0.03 14.3 0.0 1.6 1 0 0 1 1 1 0 Histidine kinase-like ATPase domain FIST PF08495.10 CAV18620.1 - 2.9e-27 95.8 0.3 1.1e-26 93.9 0.2 1.8 2 0 0 2 2 2 1 FIST N domain FIST_C PF10442.9 CAV18620.1 - 1.5e-18 67.0 0.0 3.8e-18 65.7 0.0 1.7 2 0 0 2 2 2 1 FIST C domain GrlR PF16518.5 CAV18620.1 - 0.027 14.4 0.0 0.064 13.2 0.0 1.6 1 0 0 1 1 1 0 T3SS negative regulator,GrlR Lum_binding PF00677.17 CAV18620.1 - 0.12 12.3 0.0 0.23 11.4 0.0 1.5 1 0 0 1 1 1 0 Lumazine binding domain TGBp3 PF02495.17 CAV18621.1 - 1.3 8.8 5.7 3 7.6 3.0 2.5 2 1 0 2 2 2 0 Triple gene block 3 COX1 PF00115.20 CAV18622.1 - 1.1e-117 393.6 64.5 1.2e-117 393.4 64.5 1.0 1 0 0 1 1 1 1 Cytochrome C and Quinol oxidase polypeptide I FixO PF02433.15 CAV18624.1 - 1.2e-85 286.3 0.0 1e-81 273.5 0.0 2.0 1 1 1 2 2 2 2 Cytochrome C oxidase, mono-heme subunit/FixO Cytochrom_C PF00034.21 CAV18624.1 - 0.00011 23.3 0.1 0.0024 19.0 0.1 2.3 1 1 0 1 1 1 1 Cytochrome c FixQ PF05545.11 CAV18625.1 - 1.1e-09 38.1 0.1 1.3e-09 37.9 0.1 1.1 1 0 0 1 1 1 1 Cbb3-type cytochrome oxidase component FixQ Cytochrome_CBB3 PF13442.6 CAV18626.1 - 1.4e-25 89.4 0.1 3.9e-13 49.5 0.0 2.3 2 0 0 2 2 2 2 Cytochrome C oxidase, cbb3-type, subunit III FixP_N PF14715.6 CAV18626.1 - 2.7e-24 84.6 0.7 6.5e-24 83.4 0.7 1.7 1 0 0 1 1 1 1 N-terminal domain of cytochrome oxidase-cbb3, FixP Cytochrom_C PF00034.21 CAV18626.1 - 9.7e-17 61.9 1.3 2.5e-06 28.5 0.0 4.6 3 2 0 3 3 3 2 Cytochrome c Cytochrom_C550 PF14495.6 CAV18626.1 - 0.0039 16.9 0.0 0.058 13.1 0.0 2.4 3 0 0 3 3 3 1 Cytochrome c-550 domain DUF1924 PF09086.11 CAV18626.1 - 0.024 15.0 0.2 2.6 8.5 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF1924) PSCyt1 PF07635.11 CAV18626.1 - 0.024 15.2 0.1 6.1 7.5 0.0 2.7 2 0 0 2 2 2 0 Planctomycete cytochrome C DUF3785 PF12653.7 CAV18626.1 - 0.036 14.2 0.0 0.059 13.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3785) DUF4398 PF14346.6 CAV18626.1 - 0.043 14.4 1.1 0.072 13.7 1.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4398) DUF3365 PF11845.8 CAV18626.1 - 0.048 14.0 0.3 5.7 7.2 0.1 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF3365) Cytochrome_C7 PF14522.6 CAV18626.1 - 0.065 13.2 0.0 17 5.5 0.0 2.3 2 0 0 2 2 2 0 Cytochrome c7 and related cytochrome c Paired_CXXCH_1 PF09699.10 CAV18626.1 - 0.11 12.3 0.4 19 5.1 0.1 2.3 2 0 0 2 2 2 0 Doubled CXXCH motif (Paired_CXXCH_1) FixH PF05751.11 CAV18628.1 - 4.5e-43 146.8 0.1 5e-43 146.7 0.1 1.0 1 0 0 1 1 1 1 FixH YtkA PF13115.6 CAV18628.1 - 0.094 13.3 0.0 0.16 12.6 0.0 1.7 1 1 0 1 1 1 0 YtkA-like Nterm_IS4 PF13006.7 CAV18628.1 - 0.11 12.7 0.0 0.19 12.0 0.0 1.4 1 0 0 1 1 1 0 Insertion element 4 transposase N-terminal E1-E2_ATPase PF00122.20 CAV18629.1 - 9.8e-45 152.3 1.8 3.6e-44 150.4 0.1 2.7 3 0 0 3 3 3 1 E1-E2 ATPase Hydrolase PF00702.26 CAV18629.1 - 4.6e-29 102.2 0.4 8.4e-29 101.4 0.4 1.5 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase ATPase-cat_bd PF12156.8 CAV18629.1 - 2.7e-26 92.1 0.2 5.1e-26 91.2 0.2 1.5 1 0 0 1 1 1 1 Putative metal-binding domain of cation transport ATPase HMA PF00403.26 CAV18629.1 - 1.4e-08 35.0 0.5 4.3e-08 33.5 0.0 2.1 2 0 0 2 2 2 1 Heavy-metal-associated domain Hydrolase_3 PF08282.12 CAV18629.1 - 1.5e-08 34.7 7.5 3.6e-05 23.6 1.0 2.8 3 0 0 3 3 3 2 haloacid dehalogenase-like hydrolase HAD PF12710.7 CAV18629.1 - 0.0074 16.7 0.1 0.044 14.2 0.1 2.2 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase FixS PF03597.15 CAV18631.1 - 3.8e-21 74.5 0.1 4.8e-21 74.2 0.1 1.1 1 0 0 1 1 1 1 Cytochrome oxidase maturation protein cbb3-type HIG_1_N PF04588.13 CAV18631.1 - 0.035 14.3 0.0 0.047 13.9 0.0 1.2 1 0 0 1 1 1 0 Hypoxia induced protein conserved region SCIMP PF15050.6 CAV18631.1 - 0.04 14.4 0.0 0.043 14.3 0.0 1.2 1 0 0 1 1 1 0 SCIMP protein Copper-bind PF00127.20 CAV18631.1 - 0.061 13.8 0.4 0.069 13.6 0.4 1.1 1 0 0 1 1 1 0 Copper binding proteins, plastocyanin/azurin family DUF2561 PF10812.8 CAV18631.1 - 0.12 12.4 0.0 0.13 12.3 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2561) DsbD_2 PF13386.6 CAV18633.1 - 3.9e-57 193.4 21.9 4.5e-57 193.2 21.9 1.0 1 0 0 1 1 1 1 Cytochrome C biogenesis protein transmembrane region DsbD PF02683.15 CAV18633.1 - 6.2e-05 23.0 7.0 6.2e-05 23.0 7.0 1.3 1 1 0 1 1 1 1 Cytochrome C biogenesis protein transmembrane region Zip PF02535.22 CAV18633.1 - 9.1 5.4 12.0 0.21 10.8 2.5 2.0 2 0 0 2 2 2 0 ZIP Zinc transporter HTH_Crp_2 PF13545.6 CAV18634.1 - 2.2e-17 62.8 0.0 3.5e-17 62.1 0.0 1.4 1 0 0 1 1 1 1 Crp-like helix-turn-helix domain cNMP_binding PF00027.29 CAV18634.1 - 6.9e-16 58.1 0.0 1.3e-15 57.3 0.0 1.4 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain Crp PF00325.20 CAV18634.1 - 2.9e-14 52.4 0.1 5.8e-14 51.4 0.1 1.5 1 0 0 1 1 1 1 Bacterial regulatory proteins, crp family MarR_2 PF12802.7 CAV18634.1 - 0.043 13.7 0.0 0.12 12.3 0.0 1.7 2 0 0 2 2 2 0 MarR family SPATA9 PF15824.5 CAV18634.1 - 0.13 11.6 0.0 0.2 10.9 0.0 1.2 1 0 0 1 1 1 0 Spermatogenesis-associated protein 9 zinc_ribbon_6 PF14599.6 CAV18634.1 - 0.16 12.0 1.4 0.4 10.7 0.4 2.1 2 0 0 2 2 2 0 Zinc-ribbon Usp PF00582.26 CAV18635.1 - 1.6e-32 113.0 0.0 2.1e-15 57.4 0.0 2.1 2 0 0 2 2 2 2 Universal stress protein family ATP_bind_3 PF01171.20 CAV18636.1 - 2.6e-15 56.6 0.0 4.2e-15 56.0 0.0 1.3 1 0 0 1 1 1 1 PP-loop family DUF2987 PF11205.8 CAV18637.1 - 1.4e-52 177.5 1.9 1.7e-52 177.3 1.9 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2987) Glucosaminidase PF01832.20 CAV18639.1 - 3.8e-16 59.3 0.4 9.5e-16 58.1 0.1 1.7 2 0 0 2 2 2 1 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase ABC_tran PF00005.27 CAV18641.1 - 4.3e-35 121.2 0.0 9.6e-35 120.1 0.0 1.6 1 0 0 1 1 1 1 ABC transporter TOBE_2 PF08402.10 CAV18641.1 - 3.4e-12 46.4 0.2 8.3e-12 45.1 0.2 1.7 1 0 0 1 1 1 1 TOBE domain SMC_N PF02463.19 CAV18641.1 - 7.8e-06 25.5 1.7 6.3e-05 22.5 1.7 2.1 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 CAV18641.1 - 3.6e-05 23.7 0.2 0.19 11.5 0.0 2.6 3 0 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_22 PF13401.6 CAV18641.1 - 0.00017 21.9 1.3 0.0011 19.2 1.3 2.1 1 1 0 1 1 1 1 AAA domain AAA PF00004.29 CAV18641.1 - 0.0003 21.2 0.6 0.0083 16.5 0.6 2.4 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Rad17 PF03215.15 CAV18641.1 - 0.00049 20.1 0.1 0.001 19.0 0.1 1.7 1 1 0 1 1 1 1 Rad17 P-loop domain AAA_16 PF13191.6 CAV18641.1 - 0.0035 17.7 0.1 0.0061 17.0 0.1 1.6 1 1 0 1 1 1 1 AAA ATPase domain TniB PF05621.11 CAV18641.1 - 0.0035 16.8 1.3 0.21 11.0 0.6 2.4 2 0 0 2 2 2 1 Bacterial TniB protein RsgA_GTPase PF03193.16 CAV18641.1 - 0.0065 16.4 0.5 0.063 13.2 0.1 2.5 3 0 0 3 3 3 1 RsgA GTPase ABC_ATPase PF09818.9 CAV18641.1 - 0.0093 14.8 0.3 0.17 10.7 0.0 2.6 2 1 0 2 2 2 1 Predicted ATPase of the ABC class AAA_25 PF13481.6 CAV18641.1 - 0.021 14.4 0.2 0.1 12.1 0.2 2.1 1 1 0 1 1 1 0 AAA domain AAA_28 PF13521.6 CAV18641.1 - 0.033 14.4 0.2 0.8 9.9 0.0 2.6 2 1 1 3 3 3 0 AAA domain ATPase_2 PF01637.18 CAV18641.1 - 0.034 14.1 0.1 0.1 12.5 0.1 1.9 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea NB-ARC PF00931.22 CAV18641.1 - 0.035 13.3 0.4 0.11 11.6 0.0 1.8 2 0 0 2 2 2 0 NB-ARC domain sCache_3_2 PF17203.4 CAV18641.1 - 0.04 14.0 0.1 0.075 13.2 0.1 1.4 1 0 0 1 1 1 0 Single cache domain 3 AAA_30 PF13604.6 CAV18641.1 - 0.045 13.5 0.1 0.097 12.4 0.1 1.7 1 1 0 1 1 1 0 AAA domain AAA_23 PF13476.6 CAV18641.1 - 0.063 13.8 0.4 0.063 13.8 0.4 2.1 2 0 0 2 2 2 0 AAA domain FeoB_N PF02421.18 CAV18641.1 - 0.066 12.7 0.2 1.9 8.0 0.1 2.3 2 0 0 2 2 2 0 Ferrous iron transport protein B BPD_transp_1 PF00528.22 CAV18642.1 - 2e-18 66.8 8.9 2e-18 66.8 8.9 2.1 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component BPD_transp_1 PF00528.22 CAV18643.1 - 1.5e-18 67.2 17.4 1.5e-18 67.2 17.4 2.1 1 1 1 2 2 2 2 Binding-protein-dependent transport system inner membrane component DUF3693 PF12472.8 CAV18643.1 - 0.98 9.1 7.1 2.8 7.7 0.4 3.2 2 1 1 3 3 3 0 Phage related protein SBP_bac_8 PF13416.6 CAV18644.1 - 1.3e-35 123.6 1.1 1.7e-35 123.2 1.1 1.1 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_6 PF13343.6 CAV18644.1 - 2e-32 112.6 0.5 2.7e-32 112.1 0.5 1.1 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_1 PF01547.25 CAV18644.1 - 9.3e-18 65.2 1.9 1.4e-17 64.7 1.9 1.2 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_11 PF13531.6 CAV18644.1 - 1.9e-11 44.1 0.0 3e-11 43.5 0.0 1.3 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein Lipoprotein_8 PF02030.15 CAV18644.1 - 5.1e-11 42.0 0.1 1.6e-10 40.4 0.2 1.7 2 0 0 2 2 2 1 Hypothetical lipoprotein (MG045 family) ComC PF03047.14 CAV18644.1 - 4.8 7.1 6.6 1.5 8.7 2.1 2.4 2 0 0 2 2 2 0 COMC family SBP_bac_8 PF13416.6 CAV18645.1 - 5.4e-42 144.5 2.5 6.7e-42 144.2 2.5 1.1 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_6 PF13343.6 CAV18645.1 - 4.7e-35 121.2 0.5 6.5e-35 120.7 0.5 1.1 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_1 PF01547.25 CAV18645.1 - 1.3e-17 64.8 4.7 5.9e-17 62.6 4.7 1.8 1 1 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_11 PF13531.6 CAV18645.1 - 5.4e-09 36.1 0.0 8.1e-09 35.6 0.0 1.2 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein Lipoprotein_8 PF02030.15 CAV18645.1 - 1.8e-06 27.0 0.0 6e-06 25.2 0.1 1.7 2 0 0 2 2 2 1 Hypothetical lipoprotein (MG045 family) GGDEF PF00990.21 CAV18646.1 - 1.4e-18 67.1 2.3 1e-16 61.1 2.3 2.8 1 1 0 1 1 1 1 Diguanylate cyclase, GGDEF domain SIR2 PF02146.17 CAV18647.1 - 5.3e-50 169.8 0.0 6.4e-50 169.5 0.0 1.1 1 0 0 1 1 1 1 Sir2 family TPP_enzyme_M PF00205.22 CAV18647.1 - 0.14 11.9 0.0 0.8 9.4 0.0 2.1 2 0 0 2 2 2 0 Thiamine pyrophosphate enzyme, central domain Ammonium_transp PF00909.21 CAV18648.1 - 6.9e-88 295.0 35.6 8.8e-88 294.7 35.6 1.0 1 0 0 1 1 1 1 Ammonium Transporter Family HEV_ORF1 PF02444.16 CAV18648.1 - 1.1 9.9 3.1 64 4.1 0.2 3.2 3 0 0 3 3 3 0 Hepatitis E virus ORF-2 (Putative capsid protein) CrgA PF06781.12 CAV18648.1 - 1.6 8.9 5.1 14 5.8 1.3 3.1 3 0 0 3 3 3 0 Cell division protein CrgA CD225 PF04505.12 CAV18649.1 - 0.048 13.8 0.4 0.12 12.5 0.4 1.7 1 1 0 1 1 1 0 Interferon-induced transmembrane protein DUF3671 PF12420.8 CAV18649.1 - 0.32 11.1 2.0 0.72 9.9 2.0 1.7 1 1 0 1 1 1 0 Protein of unknown function Ni_hydr_CYTB PF01292.20 CAV18650.1 - 5.6e-25 88.0 15.4 5.6e-25 88.0 15.4 1.8 2 1 0 2 2 2 1 Prokaryotic cytochrome b561 DUF4405 PF14358.6 CAV18650.1 - 0.00011 22.7 20.2 0.00021 21.8 5.5 3.1 3 0 0 3 3 3 2 Domain of unknown function (DUF4405) 2C_adapt PF08793.10 CAV18650.1 - 0.25 11.6 0.1 0.44 10.8 0.1 1.3 1 0 0 1 1 1 0 2-cysteine adaptor domain HemY_N PF07219.13 CAV18650.1 - 0.32 11.2 1.7 4.1 7.6 0.0 3.2 3 0 0 3 3 3 0 HemY protein N-terminus Fer4_7 PF12838.7 CAV18651.1 - 2.7e-13 50.3 23.0 3.7e-08 33.8 2.1 2.9 2 2 1 3 3 3 2 4Fe-4S dicluster domain Fer4_11 PF13247.6 CAV18651.1 - 1.4e-11 44.4 18.2 8.5e-10 38.7 8.1 3.0 2 1 1 3 3 3 2 4Fe-4S dicluster domain Fer4_10 PF13237.6 CAV18651.1 - 4.4e-09 36.3 31.9 3.6e-06 27.0 4.3 3.4 2 2 1 3 3 3 3 4Fe-4S dicluster domain Fer4 PF00037.27 CAV18651.1 - 6.6e-08 32.1 1.1 6.6e-08 32.1 1.1 5.3 6 0 0 6 6 6 2 4Fe-4S binding domain Fer4_9 PF13187.6 CAV18651.1 - 8.9e-08 32.2 23.4 9.1e-05 22.5 11.4 3.4 1 1 3 4 4 4 4 4Fe-4S dicluster domain Fer4_6 PF12837.7 CAV18651.1 - 4.2e-07 29.8 0.9 4.2e-07 29.8 0.9 4.3 5 0 0 5 5 5 3 4Fe-4S binding domain Fer4_21 PF14697.6 CAV18651.1 - 1.5e-06 28.2 28.2 0.0015 18.6 14.7 3.1 2 1 2 4 4 4 3 4Fe-4S dicluster domain Fer4_2 PF12797.7 CAV18651.1 - 2.5e-05 24.1 0.6 2.5e-05 24.1 0.6 4.0 5 0 0 5 5 5 3 4Fe-4S binding domain Fer4_16 PF13484.6 CAV18651.1 - 0.00022 22.1 24.6 0.038 14.9 4.6 4.3 3 1 1 4 4 4 2 4Fe-4S double cluster binding domain Fer4_4 PF12800.7 CAV18651.1 - 0.035 14.6 9.9 0.067 13.7 1.8 4.5 5 1 0 5 5 5 0 4Fe-4S binding domain Fer4_3 PF12798.7 CAV18651.1 - 0.056 14.4 3.7 0.056 14.4 3.7 4.7 4 1 0 4 4 4 0 4Fe-4S binding domain Fer4_8 PF13183.6 CAV18651.1 - 0.079 13.4 27.7 1.7 9.2 12.4 3.1 2 2 0 2 2 2 0 4Fe-4S dicluster domain Fer4_17 PF13534.6 CAV18651.1 - 3.5 8.3 35.1 1.1 9.8 4.9 4.3 2 1 1 3 3 3 0 4Fe-4S dicluster domain Molybdopterin PF00384.22 CAV18652.1 - 5.2e-53 180.5 0.2 7.6e-53 180.0 0.2 1.2 1 0 0 1 1 1 1 Molybdopterin oxidoreductase Molydop_binding PF01568.21 CAV18652.1 - 1.1e-19 70.5 0.0 2.3e-19 69.5 0.0 1.5 1 0 0 1 1 1 1 Molydopterin dinucleotide binding domain Molybdop_Fe4S4 PF04879.16 CAV18652.1 - 8.5e-12 44.9 0.8 1.9e-11 43.8 0.8 1.6 1 0 0 1 1 1 1 Molybdopterin oxidoreductase Fe4S4 domain TAT_signal PF10518.9 CAV18654.1 - 3.3e-05 23.5 1.6 4.9e-05 23.0 1.6 1.3 1 0 0 1 1 1 1 TAT (twin-arginine translocation) pathway signal sequence UCR_Fe-S_N PF10399.9 CAV18654.1 - 0.005 16.1 0.6 0.008 15.5 0.6 1.4 1 0 0 1 1 1 1 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal Nitrate_red_del PF02613.15 CAV18656.1 - 1.8e-29 102.5 0.1 4.7e-29 101.2 0.1 1.7 1 1 1 2 2 2 1 Nitrate reductase delta subunit Fer4 PF00037.27 CAV18657.1 - 3.7e-19 67.7 25.0 4.3e-06 26.3 1.2 4.9 4 0 0 4 4 4 4 4Fe-4S binding domain Fer4_7 PF12838.7 CAV18657.1 - 3.6e-17 62.7 34.0 1.5e-08 35.1 4.8 4.2 5 0 0 5 5 4 3 4Fe-4S dicluster domain Fer4_16 PF13484.6 CAV18657.1 - 5.6e-14 52.8 24.4 0.0041 18.0 6.7 5.1 4 1 0 4 4 4 4 4Fe-4S double cluster binding domain Fer4_6 PF12837.7 CAV18657.1 - 7.7e-13 47.9 38.7 3.9e-05 23.5 1.3 5.2 6 0 0 6 6 5 4 4Fe-4S binding domain Fer4_10 PF13237.6 CAV18657.1 - 2.3e-10 40.4 35.4 7.2e-06 26.0 4.6 3.8 3 1 1 4 4 3 3 4Fe-4S dicluster domain Fer4_9 PF13187.6 CAV18657.1 - 8.4e-10 38.7 36.8 0.00013 22.1 3.7 4.2 4 1 0 5 5 5 3 4Fe-4S dicluster domain Fer4_17 PF13534.6 CAV18657.1 - 2.7e-07 31.0 26.8 0.0015 19.1 4.8 5.1 4 1 1 5 5 5 2 4Fe-4S dicluster domain Fer4_8 PF13183.6 CAV18657.1 - 2.1e-05 24.9 33.5 0.033 14.6 1.0 4.5 4 2 0 4 4 3 3 4Fe-4S dicluster domain Fer4_21 PF14697.6 CAV18657.1 - 6e-05 23.1 38.6 0.0038 17.3 4.9 4.4 3 1 3 6 6 6 4 4Fe-4S dicluster domain Fer4_2 PF12797.7 CAV18657.1 - 0.00043 20.2 9.0 0.00094 19.1 1.3 5.9 7 0 0 7 7 7 4 4Fe-4S binding domain Fer4_3 PF12798.7 CAV18657.1 - 0.0048 17.7 50.1 0.041 14.8 4.5 5.8 6 0 0 6 6 6 3 4Fe-4S binding domain Fer4_18 PF13746.6 CAV18657.1 - 0.0075 16.4 10.6 0.0075 16.4 10.6 3.9 2 2 2 4 4 4 1 4Fe-4S dicluster domain Fer4_4 PF12800.7 CAV18657.1 - 0.013 16.0 1.7 0.013 16.0 1.7 5.5 7 0 0 7 7 5 0 4Fe-4S binding domain Fer4_15 PF13459.6 CAV18657.1 - 0.057 14.2 16.2 10 6.9 1.4 4.6 4 0 0 4 4 4 0 4Fe-4S single cluster domain ETF_QO PF05187.13 CAV18657.1 - 0.062 13.4 0.4 0.062 13.4 0.4 3.1 2 1 1 3 3 3 0 Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S DUF3306 PF11748.8 CAV18658.1 - 1e-27 97.4 4.5 1e-27 97.4 4.5 2.1 2 0 0 2 2 2 2 Protein of unknown function (DUF3306) DUF3305 PF11749.8 CAV18659.1 - 1.2e-20 74.1 0.1 7.1e-20 71.6 0.0 1.9 1 1 1 2 2 2 1 Protein of unknown function (DUF3305) FdhD-NarQ PF02634.15 CAV18661.1 - 4.3e-75 252.4 0.1 4.9e-75 252.2 0.1 1.0 1 0 0 1 1 1 1 FdhD/NarQ family ABC_tran PF00005.27 CAV18662.1 - 2.4e-21 76.7 0.0 3.4e-21 76.2 0.0 1.2 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 CAV18662.1 - 7.7e-08 32.5 0.0 0.00055 19.8 0.0 2.2 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system RsgA_GTPase PF03193.16 CAV18662.1 - 3e-05 24.0 0.0 4.9e-05 23.3 0.0 1.3 1 0 0 1 1 1 1 RsgA GTPase AAA_23 PF13476.6 CAV18662.1 - 0.00025 21.6 0.1 0.00039 21.0 0.1 1.3 1 1 0 1 1 1 1 AAA domain MMR_HSR1 PF01926.23 CAV18662.1 - 0.00026 21.1 0.1 0.00035 20.6 0.1 1.6 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_16 PF13191.6 CAV18662.1 - 0.00053 20.4 0.0 0.00058 20.3 0.0 1.2 1 0 0 1 1 1 1 AAA ATPase domain AAA_18 PF13238.6 CAV18662.1 - 0.00055 20.5 0.0 0.00085 19.9 0.0 1.4 1 1 0 1 1 1 1 AAA domain AAA_29 PF13555.6 CAV18662.1 - 0.001 18.8 0.1 0.0022 17.7 0.1 1.6 1 1 0 1 1 1 1 P-loop containing region of AAA domain NACHT PF05729.12 CAV18662.1 - 0.0019 18.2 0.0 0.0031 17.5 0.0 1.3 1 0 0 1 1 1 1 NACHT domain AAA_22 PF13401.6 CAV18662.1 - 0.0024 18.2 0.0 0.0072 16.6 0.0 1.8 2 0 0 2 2 2 1 AAA domain AAA_28 PF13521.6 CAV18662.1 - 0.0029 17.9 0.0 0.0043 17.3 0.0 1.3 1 0 0 1 1 1 1 AAA domain DUF2813 PF11398.8 CAV18662.1 - 0.0068 15.7 0.0 0.0077 15.5 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2813) AAA_24 PF13479.6 CAV18662.1 - 0.0083 15.9 0.0 0.017 14.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain Roc PF08477.13 CAV18662.1 - 0.01 16.0 0.9 0.055 13.7 0.1 2.1 1 1 1 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase FeoB_N PF02421.18 CAV18662.1 - 0.011 15.3 0.1 0.019 14.5 0.1 1.7 1 1 0 1 1 1 0 Ferrous iron transport protein B RNA_helicase PF00910.22 CAV18662.1 - 0.012 15.9 0.0 0.024 15.0 0.0 1.5 1 0 0 1 1 1 0 RNA helicase SMC_N PF02463.19 CAV18662.1 - 0.018 14.5 0.4 0.7 9.3 0.1 2.1 1 1 0 2 2 2 0 RecF/RecN/SMC N terminal domain AAA_5 PF07728.14 CAV18662.1 - 0.028 14.4 0.0 0.084 12.9 0.0 1.7 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA PF00004.29 CAV18662.1 - 0.03 14.7 0.0 0.11 12.9 0.0 2.0 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_15 PF13175.6 CAV18662.1 - 0.032 14.0 0.1 0.1 12.3 0.0 1.9 2 1 0 2 2 2 0 AAA ATPase domain AAA_14 PF13173.6 CAV18662.1 - 0.034 14.2 0.0 0.16 12.0 0.0 1.9 2 0 0 2 2 2 0 AAA domain Septin PF00735.18 CAV18662.1 - 0.039 13.2 0.0 0.054 12.8 0.0 1.2 1 0 0 1 1 1 0 Septin DLIC PF05783.11 CAV18662.1 - 0.04 12.7 0.0 0.054 12.3 0.0 1.1 1 0 0 1 1 1 0 Dynein light intermediate chain (DLIC) NTPase_1 PF03266.15 CAV18662.1 - 0.047 13.6 0.2 0.15 12.0 0.0 1.8 2 0 0 2 2 2 0 NTPase Mg_chelatase PF01078.21 CAV18662.1 - 0.1 11.9 0.0 7.9 5.8 0.0 2.1 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI ABC_tran_Xtn PF12848.7 CAV18662.1 - 0.11 12.6 0.0 0.18 11.8 0.0 1.4 1 0 0 1 1 1 0 ABC transporter AAA_7 PF12775.7 CAV18662.1 - 0.12 11.8 0.0 0.2 11.2 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_25 PF13481.6 CAV18662.1 - 0.13 11.8 0.0 0.22 11.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain SRP54 PF00448.22 CAV18662.1 - 0.13 11.9 0.0 0.32 10.6 0.0 1.6 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain DUF3584 PF12128.8 CAV18662.1 - 0.15 9.6 0.2 0.19 9.2 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) ATP-synt_ab PF00006.25 CAV18662.1 - 0.19 11.4 0.0 0.31 10.6 0.0 1.3 1 0 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain ABC_tran PF00005.27 CAV18663.1 - 1.8e-20 73.8 0.0 3.3e-20 73.0 0.0 1.4 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 CAV18663.1 - 1.8e-06 28.0 0.3 0.0014 18.5 0.0 2.3 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system ABC_tran_Xtn PF12848.7 CAV18663.1 - 0.00038 20.4 0.1 0.00072 19.5 0.1 1.5 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 CAV18663.1 - 0.00068 19.1 1.7 0.86 9.0 0.1 2.5 3 0 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_15 PF13175.6 CAV18663.1 - 0.0029 17.4 0.1 0.0084 15.9 0.0 1.9 2 0 0 2 2 2 1 AAA ATPase domain MeaB PF03308.16 CAV18663.1 - 0.0031 16.5 0.0 0.0053 15.8 0.0 1.3 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB MMR_HSR1 PF01926.23 CAV18663.1 - 0.012 15.7 0.0 0.023 14.8 0.0 1.7 1 1 0 1 1 1 0 50S ribosome-binding GTPase Rad17 PF03215.15 CAV18663.1 - 0.024 14.6 0.0 0.055 13.4 0.0 1.6 1 0 0 1 1 1 0 Rad17 P-loop domain GcpE PF04551.14 CAV18663.1 - 0.033 13.3 0.0 0.048 12.8 0.0 1.1 1 0 0 1 1 1 0 GcpE protein RNA_helicase PF00910.22 CAV18663.1 - 0.035 14.5 0.0 0.068 13.6 0.0 1.5 1 0 0 1 1 1 0 RNA helicase AAA_14 PF13173.6 CAV18663.1 - 0.044 13.8 0.0 1.1 9.2 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_29 PF13555.6 CAV18663.1 - 0.059 13.1 0.1 0.13 12.0 0.1 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 CAV18663.1 - 0.081 12.8 0.0 0.15 12.0 0.0 1.5 1 0 0 1 1 1 0 RsgA GTPase AAA_22 PF13401.6 CAV18663.1 - 0.083 13.2 0.1 6.8 7.0 0.0 2.5 2 0 0 2 2 2 0 AAA domain PRF PF06875.11 CAV18663.1 - 0.13 11.7 0.0 0.22 10.9 0.0 1.3 1 0 0 1 1 1 0 Plethodontid receptivity factor PRF AAA_23 PF13476.6 CAV18663.1 - 0.19 12.2 0.7 0.4 11.2 0.6 1.5 1 1 0 1 1 1 0 AAA domain AAA_22 PF13401.6 CAV18664.1 - 7.7e-08 32.7 0.2 6.1e-07 29.8 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 CAV18664.1 - 0.00026 21.4 0.0 0.00086 19.7 0.0 1.8 1 0 0 1 1 1 1 AAA ATPase domain AAA_14 PF13173.6 CAV18664.1 - 0.00062 19.8 0.0 0.0022 18.0 0.0 1.9 2 0 0 2 2 2 1 AAA domain MarR_2 PF12802.7 CAV18664.1 - 0.039 13.9 0.0 0.25 11.2 0.0 2.3 2 0 0 2 2 2 0 MarR family DAP3 PF10236.9 CAV18664.1 - 0.039 13.1 0.4 10 5.2 0.0 3.0 3 0 0 3 3 3 0 Mitochondrial ribosomal death-associated protein 3 ATPase_2 PF01637.18 CAV18664.1 - 0.067 13.1 0.0 2.9 7.8 0.0 2.3 1 1 1 2 2 2 0 ATPase domain predominantly from Archaea T2SSE PF00437.20 CAV18664.1 - 0.12 11.4 0.0 0.23 10.5 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein HTH_34 PF13601.6 CAV18664.1 - 0.13 12.5 0.0 0.29 11.3 0.0 1.6 1 0 0 1 1 1 0 Winged helix DNA-binding domain MS_channel PF00924.18 CAV18665.1 - 6.2e-35 120.6 3.6 6.2e-35 120.6 3.6 1.8 2 0 0 2 2 2 1 Mechanosensitive ion channel sCache_3_3 PF17202.4 CAV18666.1 - 4.9e-28 97.7 0.0 1.2e-27 96.4 0.0 1.6 1 0 0 1 1 1 1 Single cache domain 3 HATPase_c PF02518.26 CAV18666.1 - 1.8e-20 73.5 0.3 4.7e-20 72.2 0.3 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Cache_3-Cache_2 PF17201.4 CAV18666.1 - 1.1e-16 61.0 1.9 5.1e-15 55.5 0.1 2.5 2 0 0 2 2 2 2 Cache 3/Cache 2 fusion domain HisKA PF00512.25 CAV18666.1 - 9.1e-13 48.0 0.5 2.8e-12 46.5 0.1 2.2 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain sCache_3_2 PF17203.4 CAV18666.1 - 6.1e-07 29.7 1.0 1.7e-05 25.0 0.1 2.7 2 1 1 3 3 3 1 Single cache domain 3 GlcNAc-1_reg PF18440.1 CAV18666.1 - 0.18 12.0 1.6 1.5 9.1 0.1 2.8 2 0 0 2 2 2 0 Putative GlcNAc-1 phosphotransferase regulatory domain Fzo_mitofusin PF04799.13 CAV18666.1 - 0.31 10.6 5.0 1.7 8.2 3.0 2.6 1 1 1 2 2 2 0 fzo-like conserved region Sigma54_activat PF00158.26 CAV18667.1 - 2.7e-68 228.9 0.0 3.9e-68 228.4 0.0 1.2 1 0 0 1 1 1 1 Sigma-54 interaction domain Response_reg PF00072.24 CAV18667.1 - 1.3e-22 80.0 0.0 2.3e-22 79.3 0.0 1.4 1 0 0 1 1 1 1 Response regulator receiver domain Sigma54_activ_2 PF14532.6 CAV18667.1 - 2.1e-17 63.5 0.0 4.6e-17 62.4 0.0 1.6 1 1 0 1 1 1 1 Sigma-54 interaction domain HTH_8 PF02954.19 CAV18667.1 - 5.4e-08 32.5 0.0 1.5e-07 31.1 0.0 1.8 1 0 0 1 1 1 1 Bacterial regulatory protein, Fis family AAA_5 PF07728.14 CAV18667.1 - 6e-08 32.8 0.0 1.1e-07 31.9 0.0 1.4 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA PF00004.29 CAV18667.1 - 2.2e-06 28.2 0.0 5.6e-06 26.8 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Mg_chelatase PF01078.21 CAV18667.1 - 0.00066 19.1 0.1 0.027 13.8 0.0 2.2 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_30 PF13604.6 CAV18667.1 - 0.00093 19.0 0.0 0.0027 17.4 0.0 1.8 2 0 0 2 2 2 1 AAA domain AAA_3 PF07726.11 CAV18667.1 - 0.023 14.5 0.0 0.044 13.6 0.0 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 CAV18667.1 - 0.028 14.8 0.0 0.087 13.2 0.0 1.6 1 1 0 1 1 1 0 AAA ATPase domain IstB_IS21 PF01695.17 CAV18667.1 - 0.029 14.1 0.0 1.2 8.8 0.0 2.8 2 1 0 2 2 2 0 IstB-like ATP binding protein Torsin PF06309.11 CAV18667.1 - 0.14 12.3 0.0 0.26 11.4 0.0 1.4 1 0 0 1 1 1 0 Torsin TIP49 PF06068.13 CAV18667.1 - 0.14 11.3 0.0 0.26 10.4 0.0 1.4 1 0 0 1 1 1 0 TIP49 P-loop domain HTH_28 PF13518.6 CAV18667.1 - 0.17 12.0 0.0 0.49 10.6 0.0 1.8 1 0 0 1 1 1 0 Helix-turn-helix domain PBP_like_2 PF12849.7 CAV18668.1 - 8.3e-33 114.3 0.2 1e-32 114.0 0.2 1.0 1 0 0 1 1 1 1 PBP superfamily domain SBP_bac_11 PF13531.6 CAV18668.1 - 1.3e-07 31.6 0.0 1.2e-06 28.5 0.0 2.1 1 1 0 1 1 1 1 Bacterial extracellular solute-binding protein PBP_like PF12727.7 CAV18668.1 - 3.4e-06 26.3 0.0 5e-06 25.8 0.0 1.4 1 0 0 1 1 1 1 PBP superfamily domain LysR_substrate PF03466.20 CAV18668.1 - 0.067 12.5 0.0 0.096 12.0 0.0 1.3 1 0 0 1 1 1 0 LysR substrate binding domain BPD_transp_1 PF00528.22 CAV18669.1 - 1.4e-11 44.5 17.3 1.9e-11 44.0 17.3 1.3 1 0 0 1 1 1 1 Binding-protein-dependent transport system inner membrane component TMEM70 PF06979.12 CAV18669.1 - 0.096 13.1 4.1 0.24 11.8 4.1 1.6 1 0 0 1 1 1 0 Assembly, mitochondrial proton-transport ATP synth complex ABC_tran PF00005.27 CAV18670.1 - 3.3e-27 95.7 0.0 5.1e-27 95.1 0.0 1.3 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 CAV18670.1 - 2.5e-10 40.7 2.2 0.00014 21.8 0.1 2.2 1 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 CAV18670.1 - 0.00014 21.3 0.6 0.0012 18.3 0.0 2.1 2 0 0 2 2 2 1 RecF/RecN/SMC N terminal domain TsaE PF02367.17 CAV18670.1 - 0.0002 21.4 0.0 0.00034 20.6 0.0 1.4 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_18 PF13238.6 CAV18670.1 - 0.0018 18.8 0.0 0.0036 17.8 0.0 1.7 1 1 0 1 1 1 1 AAA domain Swi3 PF07962.12 CAV18670.1 - 0.0042 17.0 0.0 0.0096 15.9 0.0 1.5 1 0 0 1 1 1 1 Replication Fork Protection Component Swi3 AAA_29 PF13555.6 CAV18670.1 - 0.0068 16.1 0.0 0.027 14.2 0.0 1.9 3 0 0 3 3 2 1 P-loop containing region of AAA domain NACHT PF05729.12 CAV18670.1 - 0.017 15.0 0.5 0.064 13.2 0.1 2.0 2 0 0 2 2 2 0 NACHT domain AAA PF00004.29 CAV18670.1 - 0.023 15.1 0.2 0.23 11.9 0.2 2.2 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) RsgA_GTPase PF03193.16 CAV18670.1 - 0.054 13.4 0.1 0.2 11.5 0.0 2.0 2 0 0 2 2 2 0 RsgA GTPase AAA_15 PF13175.6 CAV18670.1 - 0.065 12.9 0.2 0.24 11.0 0.1 1.8 1 1 0 2 2 2 0 AAA ATPase domain AAA_5 PF07728.14 CAV18670.1 - 0.084 12.9 0.0 0.17 11.9 0.0 1.7 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 CAV18670.1 - 0.11 12.8 0.0 0.18 12.2 0.0 1.5 1 1 0 1 1 1 0 AAA ATPase domain RNA_helicase PF00910.22 CAV18670.1 - 0.13 12.7 0.0 0.27 11.6 0.0 1.7 1 0 0 1 1 1 0 RNA helicase SbcCD_C PF13558.6 CAV18670.1 - 0.13 12.5 0.1 3.6 7.9 0.1 2.3 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit AFG1_ATPase PF03969.16 CAV18670.1 - 0.14 11.0 0.0 1.5 7.7 0.0 2.0 2 0 0 2 2 2 0 AFG1-like ATPase NTPase_1 PF03266.15 CAV18670.1 - 0.19 11.6 0.3 0.81 9.6 0.1 2.0 2 0 0 2 2 2 0 NTPase NTP_transf_3 PF12804.7 CAV18671.1 - 5.4e-35 121.1 0.0 6.8e-35 120.8 0.0 1.0 1 0 0 1 1 1 1 MobA-like NTP transferase domain Glycos_transf_2 PF00535.26 CAV18671.1 - 0.035 13.9 0.0 0.048 13.5 0.0 1.3 1 0 0 1 1 1 0 Glycosyl transferase family 2 CTP_transf_3 PF02348.19 CAV18671.1 - 0.12 12.3 0.0 0.56 10.1 0.0 1.9 2 0 0 2 2 2 0 Cytidylyltransferase IspD PF01128.19 CAV18671.1 - 0.16 11.7 0.0 0.27 11.0 0.0 1.3 1 0 0 1 1 1 0 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase MobB PF03205.14 CAV18672.1 - 3.9e-47 159.5 0.0 9e-47 158.3 0.0 1.6 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B MoeA_N PF03453.17 CAV18672.1 - 3.1e-40 137.5 0.9 4.6e-40 136.9 0.9 1.3 1 0 0 1 1 1 1 MoeA N-terminal region (domain I and II) MoCF_biosynth PF00994.24 CAV18672.1 - 2.5e-26 92.0 0.0 4.8e-26 91.1 0.0 1.5 1 0 0 1 1 1 1 Probable molybdopterin binding domain MoeA_C PF03454.15 CAV18672.1 - 4.5e-20 71.6 0.0 1.1e-19 70.3 0.0 1.8 1 0 0 1 1 1 1 MoeA C-terminal region (domain IV) LpxK PF02606.14 CAV18672.1 - 0.008 15.3 0.0 0.013 14.6 0.0 1.2 1 0 0 1 1 1 1 Tetraacyldisaccharide-1-P 4'-kinase cobW PF02492.19 CAV18672.1 - 0.021 14.4 0.0 0.036 13.7 0.0 1.4 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain MeaB PF03308.16 CAV18672.1 - 0.054 12.5 0.0 0.11 11.4 0.0 1.4 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB CbiA PF01656.23 CAV18672.1 - 0.054 13.5 0.1 0.11 12.6 0.0 1.5 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_18 PF13238.6 CAV18672.1 - 0.057 14.0 0.0 0.12 12.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain GGDEF PF00990.21 CAV18673.1 - 6.5e-33 113.8 0.2 1.8e-32 112.3 0.2 1.8 1 0 0 1 1 1 1 Diguanylate cyclase, GGDEF domain GAF_2 PF13185.6 CAV18673.1 - 8e-10 39.1 0.0 1.4e-09 38.4 0.0 1.4 1 0 0 1 1 1 1 GAF domain TPR_12 PF13424.6 CAV18673.1 - 2.1e-09 37.5 4.1 1.9e-05 24.9 0.2 3.7 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 CAV18673.1 - 4.5e-08 32.6 9.3 0.055 13.6 0.1 5.3 6 0 0 6 6 4 3 Tetratricopeptide repeat GAF PF01590.26 CAV18673.1 - 1.4e-07 32.2 0.0 3.4e-07 31.0 0.0 1.7 1 0 0 1 1 1 1 GAF domain TPR_8 PF13181.6 CAV18673.1 - 9e-07 28.6 5.3 0.002 18.2 0.4 4.1 4 0 0 4 4 3 1 Tetratricopeptide repeat TPR_1 PF00515.28 CAV18673.1 - 1.3e-05 24.8 11.2 1 9.3 0.3 5.9 6 0 0 6 6 6 3 Tetratricopeptide repeat GAF_3 PF13492.6 CAV18673.1 - 5.9e-05 23.4 0.0 0.00021 21.6 0.0 2.0 2 1 0 2 2 2 1 GAF domain GCH_III PF05165.12 CAV18673.1 - 0.00081 18.7 0.0 0.097 11.9 0.0 2.4 2 0 0 2 2 2 1 GTP cyclohydrolase III TPR_7 PF13176.6 CAV18673.1 - 0.0017 18.2 6.5 3.8 7.7 0.0 5.3 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_MalT PF17874.1 CAV18673.1 - 0.0026 17.2 2.8 0.0049 16.3 0.4 2.4 2 1 0 2 2 2 1 MalT-like TPR region SMBP PF16785.5 CAV18673.1 - 0.0027 17.9 0.4 0.0095 16.1 0.4 1.9 1 0 0 1 1 1 1 Small metal-binding protein SpoVT_C PF15714.5 CAV18673.1 - 0.022 14.8 0.0 0.2 11.7 0.0 2.4 2 0 0 2 2 2 0 Stage V sporulation protein T C-terminal, transcription factor TPR_16 PF13432.6 CAV18673.1 - 0.1 13.2 0.1 2.7 8.7 0.0 2.8 3 0 0 3 3 2 0 Tetratricopeptide repeat ANAPC5 PF12862.7 CAV18673.1 - 0.21 11.7 6.2 1.8 8.7 3.8 3.5 2 1 0 2 2 2 0 Anaphase-promoting complex subunit 5 DUF2960 PF11173.8 CAV18675.1 - 5.2e-33 113.3 2.4 6.1e-33 113.1 2.4 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2960) DUF3326 PF11805.8 CAV18675.1 - 0.073 11.9 0.0 0.084 11.7 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3326) ROK PF00480.20 CAV18676.1 - 4e-71 239.9 0.0 4.5e-71 239.7 0.0 1.0 1 0 0 1 1 1 1 ROK family Glucokinase PF02685.16 CAV18676.1 - 4.6e-05 22.6 0.2 0.00088 18.4 0.2 2.3 1 1 0 1 1 1 1 Glucokinase DTW PF03942.15 CAV18677.1 - 3.8e-42 144.2 0.1 5e-42 143.9 0.1 1.1 1 0 0 1 1 1 1 DTW domain FA_hydroxylase PF04116.13 CAV18678.1 - 6.1e-26 91.3 11.6 1.2e-25 90.3 11.6 1.5 1 0 0 1 1 1 1 Fatty acid hydroxylase superfamily MCPsignal PF00015.21 CAV18679.1 - 2.2e-38 131.8 18.7 2.2e-38 131.8 18.7 4.1 3 2 2 5 5 5 2 Methyl-accepting chemotaxis protein (MCP) signalling domain HAMP PF00672.25 CAV18679.1 - 0.025 14.9 0.0 0.2 12.1 0.0 2.7 1 0 0 1 1 1 0 HAMP domain MID_pPIWI_RE PF18157.1 CAV18679.1 - 0.049 13.9 1.2 1.5 9.1 0.0 3.3 2 1 2 4 4 4 0 MID domain of pPIWI_RE PfUIS3 PF11567.8 CAV18679.1 - 0.055 13.8 1.2 1.3 9.4 0.2 3.4 3 1 1 4 4 4 0 Plasmodium falciparum UIS3 membrane protein DUF2172 PF09940.9 CAV18679.1 - 0.1 13.0 0.2 1.6 9.2 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF2172) Yopt PF09467.10 CAV18679.1 - 0.14 12.2 2.0 0.4 10.8 0.2 2.5 2 0 0 2 2 2 0 Hypothetical protein Yopt DUF1664 PF07889.12 CAV18679.1 - 0.49 10.4 26.4 3.8 7.6 1.3 6.1 4 2 1 6 6 6 0 Protein of unknown function (DUF1664) V-SNARE_C PF12352.8 CAV18679.1 - 0.84 10.0 7.1 0.38 11.1 0.2 3.8 3 1 1 4 4 4 0 Snare region anchored in the vesicle membrane C-terminus YgaB PF14182.6 CAV18679.1 - 3.7 8.0 9.1 21 5.6 3.5 4.2 4 0 0 4 4 4 0 YgaB-like protein Propep_M14 PF02244.16 CAV18679.1 - 3.8 8.0 6.0 5.5 7.5 0.1 3.1 2 1 1 3 3 3 0 Carboxypeptidase activation peptide BLOC1_2 PF10046.9 CAV18679.1 - 4.2 7.7 21.2 0.68 10.3 1.1 5.5 4 2 1 5 5 5 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 FlaC_arch PF05377.11 CAV18679.1 - 7.8 7.0 12.3 17 5.9 0.1 5.7 5 0 0 5 5 5 0 Flagella accessory protein C (FlaC) NLPC_P60 PF00877.19 CAV18680.1 - 8.5e-29 99.7 0.1 1.1e-28 99.3 0.1 1.1 1 0 0 1 1 1 1 NlpC/P60 family Peptidase_C92 PF05708.12 CAV18680.1 - 0.051 13.7 0.1 4.3 7.4 0.0 2.2 1 1 1 2 2 2 0 Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family DUF1175 PF06672.11 CAV18680.1 - 0.079 12.6 0.0 2.1 8.0 0.0 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1175) DUF3802 PF12290.8 CAV18681.1 - 9.3e-46 155.0 0.9 1e-45 154.8 0.9 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3802) TetR_C_8 PF14278.6 CAV18681.1 - 0.014 15.5 0.1 0.052 13.7 0.1 1.8 2 0 0 2 2 2 0 Transcriptional regulator C-terminal region Condensin2nSMC PF12422.8 CAV18681.1 - 0.059 13.6 0.0 0.37 11.0 0.0 1.8 1 1 1 2 2 2 0 Condensin II non structural maintenance of chromosomes subunit CK2S PF15011.6 CAV18681.1 - 0.061 13.2 0.0 0.073 12.9 0.0 1.1 1 0 0 1 1 1 0 Casein Kinase 2 substrate LemA PF04011.12 CAV18681.1 - 0.1 12.5 0.1 0.32 10.8 0.0 1.8 2 0 0 2 2 2 0 LemA family DUF3048_C PF17479.2 CAV18681.1 - 0.13 12.7 0.0 0.15 12.5 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3048) C-terminal domain Tudor_FRX1 PF18336.1 CAV18681.1 - 0.17 11.8 0.1 1 9.3 0.0 2.1 2 0 0 2 2 2 0 Fragile X mental retardation Tudor domain Fructosamin_kin PF03881.14 CAV18682.1 - 1.3e-123 411.8 0.1 1.4e-123 411.7 0.1 1.0 1 0 0 1 1 1 1 Fructosamine kinase APH PF01636.23 CAV18682.1 - 6.1e-13 49.2 0.0 8.1e-13 48.8 0.0 1.1 1 0 0 1 1 1 1 Phosphotransferase enzyme family Cys_rich_CPXG PF14255.6 CAV18683.1 - 5.8e-21 74.1 3.6 7.4e-21 73.8 3.6 1.1 1 0 0 1 1 1 1 Cysteine-rich CPXCG Elf1 PF05129.13 CAV18683.1 - 0.0015 18.6 0.8 0.0023 17.9 0.8 1.4 1 1 0 1 1 1 1 Transcription elongation factor Elf1 like RNHCP PF12647.7 CAV18683.1 - 0.0054 16.7 2.5 0.0066 16.4 2.5 1.2 1 0 0 1 1 1 1 RNHCP domain Lar_restr_allev PF14354.6 CAV18683.1 - 0.009 16.4 0.4 0.01 16.2 0.4 1.2 1 0 0 1 1 1 1 Restriction alleviation protein Lar zf-ribbon_3 PF13248.6 CAV18683.1 - 0.014 14.8 0.1 0.014 14.8 0.1 2.5 2 1 0 2 2 2 0 zinc-ribbon domain DpnI PF06044.12 CAV18683.1 - 0.034 13.8 0.2 0.035 13.7 0.2 1.0 1 0 0 1 1 1 0 Dam-replacing family Nudix_N_2 PF14803.6 CAV18683.1 - 0.056 13.4 3.1 1.9 8.5 0.1 2.5 2 1 0 2 2 2 0 Nudix N-terminal eIF-5_eIF-2B PF01873.17 CAV18683.1 - 0.14 12.1 1.0 0.18 11.7 1.0 1.2 1 0 0 1 1 1 0 Domain found in IF2B/IF5 DUF3797 PF12677.7 CAV18683.1 - 0.14 12.0 5.4 1.4 8.8 0.1 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF3797) Terminase_GpA PF05876.12 CAV18683.1 - 0.23 10.0 1.7 0.31 9.5 1.7 1.4 1 1 0 1 1 1 0 Phage terminase large subunit (GpA) Ogr_Delta PF04606.12 CAV18683.1 - 0.31 11.1 0.4 0.31 11.1 0.4 2.1 2 0 0 2 2 2 0 Ogr/Delta-like zinc finger Zn_Tnp_IS1595 PF12760.7 CAV18683.1 - 0.52 10.3 7.5 23 5.1 8.5 2.1 1 1 1 2 2 2 0 Transposase zinc-ribbon domain DUF2116 PF09889.9 CAV18683.1 - 0.79 9.7 6.4 2.6 8.1 1.3 2.1 2 0 0 2 2 2 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) UPF0547 PF10571.9 CAV18683.1 - 0.97 9.6 8.2 0.34 11.0 1.4 2.2 2 0 0 2 2 2 0 Uncharacterised protein family UPF0547 CpXC PF14353.6 CAV18683.1 - 1.9 8.6 5.6 1.7 8.7 0.1 2.4 1 1 1 2 2 2 0 CpXC protein Lum_binding PF00677.17 CAV18685.1 - 2.5e-44 149.2 3.0 3.6e-21 74.9 0.0 2.3 2 0 0 2 2 2 2 Lumazine binding domain MatE PF01554.18 CAV18686.1 - 2.4e-65 219.1 39.9 2.2e-35 121.7 17.2 3.4 3 1 1 4 4 4 2 MatE Polysacc_synt_C PF14667.6 CAV18686.1 - 1.4e-05 25.2 20.6 1.4e-05 25.2 20.6 4.6 2 2 2 4 4 4 1 Polysaccharide biosynthesis C-terminal domain DNA_ligase_OB_2 PF14743.6 CAV18687.1 - 3.2e-26 91.1 1.2 7.4e-26 90.0 0.8 1.8 2 0 0 2 2 2 1 DNA ligase OB-like domain DNA_ligase_A_M PF01068.21 CAV18687.1 - 9.8e-06 25.4 0.0 3.4e-05 23.6 0.0 1.8 1 1 0 1 1 1 1 ATP dependent DNA ligase domain ParA PF10609.9 CAV18687.1 - 0.0022 17.5 0.0 0.004 16.7 0.0 1.3 1 0 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase RNA_ligase PF09414.10 CAV18687.1 - 0.0056 17.0 0.0 0.013 15.8 0.0 1.5 1 1 0 1 1 1 1 RNA ligase mRNA_cap_enzyme PF01331.19 CAV18687.1 - 0.18 11.6 0.0 5.4 6.8 0.0 2.1 2 0 0 2 2 2 0 mRNA capping enzyme, catalytic domain STAS_2 PF13466.6 CAV18688.1 - 4.4e-10 39.8 0.0 5.3e-10 39.5 0.0 1.1 1 0 0 1 1 1 1 STAS domain STAS PF01740.21 CAV18688.1 - 1.5e-09 37.5 0.0 1.7e-09 37.3 0.0 1.0 1 0 0 1 1 1 1 STAS domain OmpA PF00691.20 CAV18689.1 - 1.3e-19 70.3 0.0 2.2e-19 69.6 0.0 1.3 1 0 0 1 1 1 1 OmpA family SLBB PF10531.9 CAV18690.1 - 2e-54 181.3 3.8 1e-10 41.3 0.0 6.3 6 0 0 6 6 6 6 SLBB domain Poly_export PF02563.16 CAV18690.1 - 3.8e-10 39.8 0.1 1.6e-09 37.9 0.1 2.1 2 0 0 2 2 2 1 Polysaccharide biosynthesis/export protein Caps_synth_GfcC PF06251.11 CAV18690.1 - 5.9e-07 29.3 0.0 0.32 10.6 0.0 5.2 2 2 3 5 5 5 3 Capsule biosynthesis GfcC AAA_31 PF13614.6 CAV18691.1 - 3.3e-06 27.1 0.2 0.00029 20.8 0.2 2.3 1 1 0 1 1 1 1 AAA domain CBP_BcsQ PF06564.12 CAV18691.1 - 0.00053 19.5 0.1 0.24 10.8 0.0 2.2 2 0 0 2 2 2 2 Cellulose biosynthesis protein BcsQ AAA_26 PF13500.6 CAV18691.1 - 0.0019 18.1 0.3 0.0097 15.7 0.3 1.9 1 1 0 1 1 1 1 AAA domain ParA PF10609.9 CAV18691.1 - 0.0071 15.8 0.0 0.034 13.6 0.0 1.8 1 1 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase CbiA PF01656.23 CAV18691.1 - 0.031 14.3 0.0 0.041 13.9 0.0 1.2 1 0 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain IstB_IS21 PF01695.17 CAV18691.1 - 0.082 12.6 0.1 0.13 11.9 0.1 1.5 1 1 0 1 1 1 0 IstB-like ATP binding protein CbeA_antitoxin PF06154.11 CAV18691.1 - 0.087 13.4 0.1 11 6.6 0.0 2.6 2 0 0 2 2 2 0 CbeA_antitoxin, type IV, cytoskeleton bundling-enhancing factor A OpuAC PF04069.12 CAV18692.1 - 3.5e-60 203.8 0.0 5.2e-60 203.2 0.0 1.3 1 0 0 1 1 1 1 Substrate binding domain of ABC-type glycine betaine transport system Sterol_MT_C PF08498.10 CAV18692.1 - 0.16 12.3 0.0 0.32 11.3 0.0 1.5 1 0 0 1 1 1 0 Sterol methyltransferase C-terminal BPD_transp_1 PF00528.22 CAV18693.1 - 4.5e-28 98.2 14.6 4.5e-28 98.2 14.6 2.0 2 1 0 2 2 2 1 Binding-protein-dependent transport system inner membrane component ABC_tran PF00005.27 CAV18694.1 - 4.6e-33 114.6 0.1 9.2e-33 113.7 0.1 1.5 1 0 0 1 1 1 1 ABC transporter CBS PF00571.28 CAV18694.1 - 1.1e-05 25.7 0.1 0.024 15.1 0.1 2.7 2 0 0 2 2 2 2 CBS domain AAA_22 PF13401.6 CAV18694.1 - 0.00024 21.4 0.3 0.00082 19.7 0.3 1.9 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 CAV18694.1 - 0.00042 20.7 0.1 0.0013 19.1 0.1 1.9 1 1 0 1 1 1 1 AAA ATPase domain AAA_29 PF13555.6 CAV18694.1 - 0.00045 19.9 0.0 0.00086 19.0 0.0 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain ABC_ATPase PF09818.9 CAV18694.1 - 0.0013 17.6 0.3 0.29 9.9 0.0 2.2 2 0 0 2 2 2 2 Predicted ATPase of the ABC class RsgA_GTPase PF03193.16 CAV18694.1 - 0.0013 18.7 0.1 0.0029 17.5 0.1 1.6 1 0 0 1 1 1 1 RsgA GTPase ATPase_2 PF01637.18 CAV18694.1 - 0.0014 18.6 0.4 0.0052 16.7 0.4 2.0 1 1 0 1 1 1 1 ATPase domain predominantly from Archaea AAA_21 PF13304.6 CAV18694.1 - 0.0018 18.2 0.2 1.3 8.8 0.0 2.3 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 CAV18694.1 - 0.0081 15.6 0.8 0.35 10.3 0.8 2.2 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain Mg_chelatase PF01078.21 CAV18694.1 - 0.019 14.3 0.0 0.038 13.4 0.0 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_23 PF13476.6 CAV18694.1 - 0.02 15.4 0.7 0.051 14.1 0.1 1.9 2 0 0 2 2 2 0 AAA domain AAA_30 PF13604.6 CAV18694.1 - 0.042 13.6 0.0 0.087 12.5 0.0 1.7 1 1 0 1 1 1 0 AAA domain AAA_33 PF13671.6 CAV18694.1 - 0.043 14.0 0.0 0.25 11.5 0.0 2.3 3 0 0 3 3 3 0 AAA domain Adeno_IVa2 PF02456.15 CAV18694.1 - 0.054 12.3 0.0 0.097 11.4 0.0 1.4 1 0 0 1 1 1 0 Adenovirus IVa2 protein Viral_helicase1 PF01443.18 CAV18694.1 - 0.077 12.7 0.0 0.31 10.7 0.0 2.0 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase SRP54 PF00448.22 CAV18694.1 - 0.088 12.4 0.2 0.86 9.2 0.0 2.5 3 0 0 3 3 3 0 SRP54-type protein, GTPase domain TniB PF05621.11 CAV18694.1 - 0.093 12.1 0.1 0.44 9.9 0.0 2.0 2 0 0 2 2 2 0 Bacterial TniB protein G-alpha PF00503.20 CAV18694.1 - 0.14 11.3 0.1 0.31 10.2 0.0 1.4 1 1 0 1 1 1 0 G-protein alpha subunit MMR_HSR1 PF01926.23 CAV18694.1 - 0.2 11.8 0.9 0.66 10.1 0.3 2.3 2 1 0 2 2 1 0 50S ribosome-binding GTPase Hpt PF01627.23 CAV18695.1 - 8.4e-10 38.8 4.0 8.4e-10 38.8 4.0 1.6 2 0 0 2 2 2 1 Hpt domain Smoothelin PF12510.8 CAV18695.1 - 0.051 13.6 0.2 0.13 12.3 0.2 1.6 1 0 0 1 1 1 0 Smoothelin cytoskeleton protein Sigma54_activat PF00158.26 CAV18696.1 - 4.5e-68 228.2 0.0 6.7e-68 227.6 0.0 1.3 1 0 0 1 1 1 1 Sigma-54 interaction domain Response_reg PF00072.24 CAV18696.1 - 3.4e-22 78.7 0.0 5.9e-22 77.9 0.0 1.4 1 0 0 1 1 1 1 Response regulator receiver domain Sigma54_activ_2 PF14532.6 CAV18696.1 - 4.5e-22 78.7 0.0 1.1e-21 77.4 0.0 1.7 1 1 0 1 1 1 1 Sigma-54 interaction domain HTH_8 PF02954.19 CAV18696.1 - 3.2e-09 36.4 0.0 8.9e-09 35.0 0.0 1.8 2 0 0 2 2 2 1 Bacterial regulatory protein, Fis family AAA_5 PF07728.14 CAV18696.1 - 5.2e-08 33.0 0.0 9.3e-08 32.2 0.0 1.4 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA PF00004.29 CAV18696.1 - 2.9e-05 24.5 0.0 7.1e-05 23.2 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Mg_chelatase PF01078.21 CAV18696.1 - 0.00035 20.0 0.0 0.0036 16.7 0.0 2.1 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI HTH_29 PF13551.6 CAV18696.1 - 0.08 13.0 0.0 0.23 11.5 0.0 1.7 2 0 0 2 2 2 0 Winged helix-turn helix TIP49 PF06068.13 CAV18696.1 - 0.12 11.5 0.0 0.25 10.5 0.0 1.5 1 0 0 1 1 1 0 TIP49 P-loop domain Glyco_trans_1_4 PF13692.6 CAV18697.1 - 1.9e-20 73.6 0.0 3.5e-20 72.8 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glycos_transf_1 PF00534.20 CAV18697.1 - 6.8e-20 71.3 0.0 1.2e-19 70.5 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.6 CAV18697.1 - 2.8e-14 53.9 0.0 5e-13 49.8 0.0 2.1 2 0 0 2 2 2 1 Glycosyl transferase 4-like domain Glyco_transf_4 PF13439.6 CAV18697.1 - 7.1e-09 35.9 0.0 6.8e-08 32.7 0.0 2.3 2 0 0 2 2 2 1 Glycosyltransferase Family 4 Glyco_trans_1_2 PF13524.6 CAV18697.1 - 0.00012 22.4 0.0 0.00025 21.4 0.0 1.6 1 0 0 1 1 1 1 Glycosyl transferases group 1 Wzy_C PF04932.15 CAV18698.1 - 2.4e-19 69.5 7.9 2.4e-19 69.5 7.9 3.8 3 1 1 4 4 4 1 O-Antigen ligase Hexapep PF00132.24 CAV18699.1 - 2.2e-12 46.2 14.4 6.3e-08 32.1 1.4 4.6 4 1 1 5 5 5 4 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 CAV18699.1 - 2.6e-10 39.9 13.0 4.9e-06 26.2 1.1 3.3 3 0 0 3 3 3 3 Hexapeptide repeat of succinyl-transferase Glyco_trans_1_4 PF13692.6 CAV18700.1 - 2.3e-08 34.5 0.0 4.2e-08 33.7 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glycos_transf_1 PF00534.20 CAV18700.1 - 0.0017 17.9 0.0 0.0041 16.7 0.0 1.7 1 0 0 1 1 1 1 Glycosyl transferases group 1 DUF2019 PF09450.10 CAV18700.1 - 0.13 12.2 0.0 0.26 11.3 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF2019) Wzz PF02706.15 CAV18701.1 - 3e-06 27.5 0.1 1e-05 25.7 0.1 2.0 1 0 0 1 1 1 1 Chain length determinant protein GNVR PF13807.6 CAV18701.1 - 0.00015 21.6 0.0 0.00038 20.3 0.0 1.7 1 0 0 1 1 1 1 G-rich domain on putative tyrosine kinase Phage_GPO PF05929.11 CAV18701.1 - 0.0098 15.5 1.9 0.0098 15.5 1.9 2.6 2 1 0 2 2 2 1 Phage capsid scaffolding protein (GPO) serine peptidase DUF1664 PF07889.12 CAV18701.1 - 0.013 15.5 9.6 0.21 11.6 2.3 3.4 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) Tautomerase_2 PF14552.6 CAV18701.1 - 0.026 14.6 0.4 7.7 6.7 0.0 3.1 3 0 0 3 3 3 0 Tautomerase enzyme MetOD2 PF18548.1 CAV18701.1 - 0.036 14.2 3.0 1.6 8.9 0.4 3.0 2 0 0 2 2 2 0 Metanogen output domain 2 DUF724 PF05266.14 CAV18701.1 - 0.042 13.7 13.1 0.048 13.5 5.9 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF724) BLOC1_2 PF10046.9 CAV18701.1 - 0.15 12.4 13.2 1 9.7 0.4 3.8 2 1 1 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Laminin_II PF06009.12 CAV18701.1 - 0.15 12.1 9.1 1.1 9.3 2.2 2.7 1 1 1 2 2 2 0 Laminin Domain II HrpB7 PF09486.10 CAV18701.1 - 0.19 12.1 0.1 0.19 12.1 0.1 3.8 2 1 2 4 4 4 0 Bacterial type III secretion protein (HrpB7) DUF5446 PF17522.2 CAV18701.1 - 0.61 10.3 7.3 7.8 6.7 0.3 3.5 1 1 2 3 3 3 0 Family of unknown function (DUF5446) ABC_tran_CTD PF16326.5 CAV18701.1 - 0.65 10.3 22.5 4.8 7.5 1.5 4.1 2 1 0 3 3 3 0 ABC transporter C-terminal domain FliJ PF02050.16 CAV18701.1 - 0.7 10.1 10.2 0.14 12.4 3.4 2.7 2 1 1 3 3 3 0 Flagellar FliJ protein DUF948 PF06103.11 CAV18701.1 - 1.4 9.2 5.2 15 5.9 0.1 3.5 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF948) DUF4407 PF14362.6 CAV18701.1 - 2.1 7.6 9.8 11 5.2 9.7 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) Mod_r PF07200.13 CAV18701.1 - 2.9 8.0 27.3 0.24 11.5 4.7 3.5 1 1 2 3 3 3 0 Modifier of rudimentary (Mod(r)) protein MPS2 PF17060.5 CAV18701.1 - 8.1 5.6 14.7 14 4.8 2.8 2.2 1 1 1 2 2 2 0 Monopolar spindle protein 2 Glycos_transf_1 PF00534.20 CAV18702.1 - 1.8e-30 105.7 0.0 4.8e-30 104.3 0.0 1.7 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 CAV18702.1 - 2.9e-22 79.5 0.0 5.6e-22 78.6 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 CAV18702.1 - 2.9e-14 53.4 0.0 4.3e-14 52.9 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_trans_4_2 PF13477.6 CAV18702.1 - 2.4e-07 30.8 0.1 4.4e-07 30.0 0.1 1.4 1 0 0 1 1 1 1 Glycosyl transferase 4-like Glyco_trans_4_4 PF13579.6 CAV18702.1 - 3e-05 24.5 0.4 5.7e-05 23.6 0.4 1.4 1 0 0 1 1 1 1 Glycosyl transferase 4-like domain Glyco_tranf_2_3 PF13641.6 CAV18703.1 - 2e-15 57.3 0.0 2.9e-15 56.8 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glycos_transf_2 PF00535.26 CAV18703.1 - 6.4e-10 39.1 0.0 1.2e-09 38.2 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_trans_2_3 PF13632.6 CAV18703.1 - 1.1e-06 28.7 0.0 2e-06 27.9 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family group 2 Glyco_tranf_2_2 PF10111.9 CAV18703.1 - 0.00072 19.1 0.4 0.001 18.6 0.4 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_transf_21 PF13506.6 CAV18703.1 - 0.00075 19.0 0.0 0.0012 18.4 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 21 Anp1 PF03452.14 CAV18703.1 - 0.055 12.9 0.0 0.093 12.1 0.0 1.3 1 0 0 1 1 1 0 Anp1 Bac_transf PF02397.16 CAV18704.1 - 4e-63 212.3 0.0 4.6e-63 212.2 0.0 1.0 1 0 0 1 1 1 1 Bacterial sugar transferase MCPsignal PF00015.21 CAV18705.1 - 3e-46 157.4 36.4 1.3e-43 148.8 17.3 3.0 1 1 1 2 2 2 2 Methyl-accepting chemotaxis protein (MCP) signalling domain sCache_2 PF17200.4 CAV18705.1 - 7.4e-32 110.3 0.0 7.4e-32 110.3 0.0 2.8 3 1 0 3 3 2 1 Single Cache domain 2 dCache_2 PF08269.11 CAV18705.1 - 2.2e-27 96.0 0.0 2.2e-27 96.0 0.0 2.6 2 1 0 2 2 2 1 Cache domain HAMP PF00672.25 CAV18705.1 - 5e-15 55.6 0.1 2.8e-13 50.0 0.0 3.6 3 0 0 3 3 3 1 HAMP domain DUF948 PF06103.11 CAV18705.1 - 0.0056 16.9 3.1 0.0056 16.9 3.1 5.5 3 2 3 6 6 6 3 Bacterial protein of unknown function (DUF948) IFT57 PF10498.9 CAV18705.1 - 0.0082 15.1 17.5 0.015 14.3 7.8 2.6 3 0 0 3 3 3 2 Intra-flagellar transport protein 57 CALCOCO1 PF07888.11 CAV18705.1 - 0.018 14.0 11.6 0.01 14.8 9.5 1.5 1 1 1 2 2 2 0 Calcium binding and coiled-coil domain (CALCOCO1) like dCache_1 PF02743.18 CAV18705.1 - 0.059 13.1 0.0 0.059 13.1 0.0 3.1 2 1 0 2 2 1 0 Cache domain BLOC1_2 PF10046.9 CAV18705.1 - 0.11 12.8 19.9 0.3 11.4 4.2 4.5 2 2 3 5 5 5 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Laminin_II PF06009.12 CAV18705.1 - 0.36 10.8 30.3 0.3 11.1 11.0 3.9 3 1 1 4 4 4 0 Laminin Domain II Sec34 PF04136.15 CAV18705.1 - 0.41 10.5 19.3 2.6 7.9 0.4 4.3 2 2 2 4 4 4 0 Sec34-like family BAR_3 PF16746.5 CAV18705.1 - 0.42 10.3 13.3 1.3 8.7 5.2 3.1 2 1 1 3 3 3 0 BAR domain of APPL family APG6_N PF17675.1 CAV18705.1 - 0.44 11.1 6.1 6.8 7.2 2.2 3.4 3 1 1 4 4 4 0 Apg6 coiled-coil region DUF3087 PF11286.8 CAV18705.1 - 0.52 9.8 5.9 0.25 10.8 1.6 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3087) Seryl_tRNA_N PF02403.22 CAV18705.1 - 0.56 10.5 12.8 0.48 10.7 0.2 3.6 3 1 1 4 4 3 0 Seryl-tRNA synthetase N-terminal domain DUF4519 PF15012.6 CAV18705.1 - 0.71 10.1 4.8 0.77 10.0 0.1 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4519) Mce4_CUP1 PF11887.8 CAV18705.1 - 0.79 9.1 19.6 2.5 7.5 2.5 2.6 1 1 0 2 2 2 0 Cholesterol uptake porter CUP1 of Mce4, putative DUF4200 PF13863.6 CAV18705.1 - 0.93 9.9 4.7 0.49 10.8 0.8 2.6 3 0 0 3 3 1 0 Domain of unknown function (DUF4200) HATPase_c_2 PF13581.6 CAV18705.1 - 1 9.3 8.7 0.81 9.7 0.1 3.3 3 1 0 3 3 3 0 Histidine kinase-like ATPase domain DUF1664 PF07889.12 CAV18705.1 - 1.7 8.7 22.8 1.9 8.6 8.2 4.1 2 2 2 4 4 4 0 Protein of unknown function (DUF1664) DUF3450 PF11932.8 CAV18705.1 - 1.9 7.7 25.2 0.1 11.9 1.5 3.9 3 1 1 4 4 4 0 Protein of unknown function (DUF3450) V_ATPase_I PF01496.19 CAV18705.1 - 2.9 5.7 14.6 0.43 8.5 10.4 1.7 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family APG17 PF04108.12 CAV18705.1 - 5.2 6.1 20.4 1.8 7.6 0.9 3.0 1 1 1 3 3 3 0 Autophagy protein Apg17 DivIVA PF05103.13 CAV18705.1 - 5.4 7.1 20.3 0.42 10.7 10.0 3.3 3 0 0 3 3 3 0 DivIVA protein Tweety PF04906.13 CAV18705.1 - 5.7 5.5 18.0 1.6 7.3 8.8 3.0 2 1 1 3 3 3 0 Tweety CENP-F_leu_zip PF10473.9 CAV18705.1 - 6.1 6.9 12.9 9.8 6.2 5.8 3.1 1 1 2 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Syntaxin_2 PF14523.6 CAV18705.1 - 6.1 7.3 26.6 4 7.9 9.8 4.6 4 1 1 5 5 5 0 Syntaxin-like protein TPR_MLP1_2 PF07926.12 CAV18705.1 - 7.6 6.6 22.7 0.13 12.3 11.0 3.1 3 1 0 3 3 3 0 TPR/MLP1/MLP2-like protein FUSC PF04632.12 CAV18705.1 - 8.1 4.8 9.4 15 4.0 9.2 1.6 1 1 0 1 1 1 0 Fusaric acid resistance protein family ISG65-75 PF11727.8 CAV18705.1 - 8.7 5.5 16.4 1.8 7.8 10.2 2.4 1 1 1 2 2 2 0 Invariant surface glycoprotein DUF3829 PF12889.7 CAV18705.1 - 9.1 5.7 12.6 24 4.3 5.8 3.4 3 1 1 4 4 4 0 Protein of unknown function (DUF3829) HTH_1 PF00126.27 CAV18706.1 - 1.3e-18 66.7 0.1 2e-18 66.1 0.1 1.3 1 0 0 1 1 1 1 Bacterial regulatory helix-turn-helix protein, lysR family LysR_substrate PF03466.20 CAV18706.1 - 0.004 16.6 0.0 0.0061 15.9 0.0 1.3 1 0 0 1 1 1 1 LysR substrate binding domain HTH_IclR PF09339.10 CAV18706.1 - 0.068 13.0 0.1 0.35 10.7 0.0 2.1 2 0 0 2 2 2 0 IclR helix-turn-helix domain HTH_24 PF13412.6 CAV18706.1 - 0.075 12.6 0.0 0.14 11.7 0.0 1.5 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding HTH_20 PF12840.7 CAV18706.1 - 0.096 12.8 0.0 0.23 11.6 0.0 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain MarR_2 PF12802.7 CAV18706.1 - 0.13 12.2 0.0 0.27 11.2 0.0 1.5 1 0 0 1 1 1 0 MarR family LysR_substrate PF03466.20 CAV18707.1 - 1.3e-21 77.0 0.0 1.5e-21 76.7 0.0 1.0 1 0 0 1 1 1 1 LysR substrate binding domain HlyD_D23 PF16576.5 CAV18708.1 - 1.2e-14 54.1 0.5 2.7e-14 52.9 0.5 1.6 1 1 0 1 1 1 1 Barrel-sandwich domain of CusB or HlyD membrane-fusion HlyD_3 PF13437.6 CAV18708.1 - 1.5e-13 51.3 0.2 1.5e-09 38.5 0.0 2.7 2 0 0 2 2 2 2 HlyD family secretion protein Biotin_lipoyl_2 PF13533.6 CAV18708.1 - 4.2e-11 42.5 1.0 1.9e-10 40.4 0.1 2.4 3 0 0 3 3 3 1 Biotin-lipoyl like Biotin_lipoyl PF00364.22 CAV18708.1 - 0.0038 17.0 0.1 0.021 14.7 0.0 2.2 2 1 0 2 2 2 1 Biotin-requiring enzyme RnfC_N PF13375.6 CAV18708.1 - 0.01 15.8 0.5 0.12 12.4 0.0 2.7 3 0 0 3 3 3 0 RnfC Barrel sandwich hybrid domain Peptidase_M23 PF01551.22 CAV18708.1 - 0.028 14.6 0.8 1.1 9.6 0.0 3.2 3 1 1 4 4 4 0 Peptidase family M23 PYNP_C PF07831.13 CAV18708.1 - 0.11 12.2 0.0 0.64 9.7 0.0 2.2 2 0 0 2 2 2 0 Pyrimidine nucleoside phosphorylase C-terminal domain PPP1R35_C PF15503.6 CAV18708.1 - 0.11 12.3 0.8 0.18 11.6 0.2 1.7 2 0 0 2 2 2 0 Protein phosphatase 1 regulatory subunit 35 C-terminus ACR_tran PF00873.19 CAV18709.1 - 2.7e-148 495.5 17.1 6.6e-148 494.2 17.1 1.5 1 1 0 1 1 1 1 AcrB/AcrD/AcrF family EI24 PF07264.11 CAV18709.1 - 0.086 13.1 0.1 0.086 13.1 0.1 3.6 2 1 1 3 3 3 0 Etoposide-induced protein 2.4 (EI24) Asp23 PF03780.13 CAV18709.1 - 0.16 12.4 3.2 7.5 7.0 0.1 3.2 3 0 0 3 3 3 0 Asp23 family, cell envelope-related function OEP PF02321.18 CAV18710.1 - 7.4e-39 133.5 12.1 7e-24 84.7 1.5 2.1 2 0 0 2 2 2 2 Outer membrane efflux protein zf-H2C2_2 PF13465.6 CAV18712.1 - 0.033 14.6 0.9 1.3 9.6 0.2 2.2 2 0 0 2 2 2 0 Zinc-finger double domain zinc_ribbon_4 PF13717.6 CAV18712.1 - 0.047 13.6 1.8 1.9 8.5 0.1 2.4 2 0 0 2 2 2 0 zinc-ribbon domain zinc_ribbon_12 PF11331.8 CAV18712.1 - 0.13 12.1 1.1 1.6 8.6 0.2 2.3 2 0 0 2 2 2 0 Probable zinc-ribbon domain UPF0128 PF03673.13 CAV18713.1 - 0.032 13.7 0.0 0.044 13.3 0.0 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0128) ABC2_membrane_3 PF12698.7 CAV18714.1 - 0.034 13.3 5.1 0.039 13.1 5.1 1.2 1 0 0 1 1 1 0 ABC-2 family transporter protein Ribosomal_L37ae PF01780.19 CAV18714.1 - 0.095 12.8 0.3 0.16 12.1 0.3 1.4 1 0 0 1 1 1 0 Ribosomal L37ae protein family zf-C2HC5 PF06221.13 CAV18714.1 - 0.11 12.4 1.3 0.17 11.9 1.3 1.2 1 0 0 1 1 1 0 Putative zinc finger motif, C2HC5-type zf-ribbon_3 PF13248.6 CAV18714.1 - 0.18 11.2 2.1 1.4 8.4 0.1 2.1 2 0 0 2 2 2 0 zinc-ribbon domain Acetyltransf_3 PF13302.7 CAV18716.1 - 7.5e-19 68.8 0.0 1e-18 68.3 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 CAV18716.1 - 1.4e-09 38.3 0.0 1.9e-09 37.8 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 CAV18716.1 - 2.3e-06 27.8 0.0 3.5e-06 27.3 0.0 1.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_8 PF13523.6 CAV18716.1 - 0.0063 16.2 0.0 0.013 15.2 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain DUF2867 PF11066.8 CAV18717.1 - 9.3e-36 123.3 0.0 1.1e-35 123.1 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2867) HAD_2 PF13419.6 CAV18719.1 - 2.4e-32 112.5 0.0 2.8e-32 112.2 0.0 1.1 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 CAV18719.1 - 2.5e-13 50.8 0.1 1.9e-11 44.6 0.1 2.1 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 CAV18719.1 - 1.9e-07 31.7 0.0 2.7e-07 31.2 0.0 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 CAV18719.1 - 3.1e-05 23.9 0.0 6.7e-05 22.9 0.0 1.5 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase_6 PF13344.6 CAV18719.1 - 0.058 13.5 0.2 1.3 9.2 0.2 2.4 1 1 0 1 1 1 0 Haloacid dehalogenase-like hydrolase Methyltransf_23 PF13489.6 CAV18719.1 - 0.062 13.1 0.0 0.077 12.8 0.0 1.4 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_11 PF08241.12 CAV18721.1 - 3.9e-14 53.1 0.0 6.6e-14 52.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CAV18721.1 - 9.6e-14 51.9 0.0 1.6e-13 51.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CAV18721.1 - 3.4e-11 43.2 0.0 6.7e-11 42.3 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CAV18721.1 - 6.2e-09 35.8 0.0 8.7e-09 35.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CAV18721.1 - 2.4e-06 28.2 0.0 5.1e-06 27.2 0.0 1.6 2 0 0 2 2 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 CAV18721.1 - 3.3e-05 23.4 0.0 4.4e-05 22.9 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family TehB PF03848.14 CAV18721.1 - 0.00067 19.1 0.0 0.0017 17.8 0.0 1.7 2 0 0 2 2 2 1 Tellurite resistance protein TehB MTS PF05175.14 CAV18721.1 - 0.0029 17.2 0.0 0.0044 16.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain NodS PF05401.11 CAV18721.1 - 0.0056 16.3 0.0 0.0085 15.7 0.0 1.2 1 0 0 1 1 1 1 Nodulation protein S (NodS) Methyltransf_8 PF05148.15 CAV18721.1 - 0.0075 16.1 0.0 0.013 15.4 0.0 1.4 1 1 0 1 1 1 1 Hypothetical methyltransferase Met_10 PF02475.16 CAV18721.1 - 0.0081 15.9 0.0 0.013 15.2 0.0 1.3 1 0 0 1 1 1 1 Met-10+ like-protein Methyltransf_7 PF03492.15 CAV18721.1 - 0.017 14.3 0.0 0.025 13.8 0.0 1.2 1 0 0 1 1 1 0 SAM dependent carboxyl methyltransferase RrnaAD PF00398.20 CAV18721.1 - 0.032 13.3 0.0 0.046 12.8 0.0 1.2 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase DUF4191 PF13829.6 CAV18723.1 - 0.13 11.6 0.0 0.15 11.4 0.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4191) OAD_gamma PF04277.13 CAV18723.1 - 1.8 9.2 5.9 3.7 8.2 0.5 2.1 1 1 1 2 2 2 0 Oxaloacetate decarboxylase, gamma chain Transposase_20 PF02371.16 CAV18725.1 - 5e-22 78.0 0.2 6.8e-22 77.6 0.2 1.2 1 0 0 1 1 1 1 Transposase IS116/IS110/IS902 family Vitellogenin_N PF01347.22 CAV18725.1 - 0.063 11.7 0.1 0.075 11.4 0.1 1.1 1 0 0 1 1 1 0 Lipoprotein amino terminal region HEPN_RiboL-PSP PF18735.1 CAV18726.1 - 0.044 13.7 0.1 0.31 10.9 0.0 2.0 1 1 1 2 2 2 0 RiboL-PSP-HEPN CN_hydrolase PF00795.22 CAV18727.1 - 6.7e-19 68.2 0.0 8.1e-19 68.0 0.0 1.0 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase CW_binding_2 PF04122.12 CAV18727.1 - 0.16 12.6 0.0 0.28 11.9 0.0 1.4 1 0 0 1 1 1 0 Putative cell wall binding repeat 2 Y2_Tnp PF04986.13 CAV18728.1 - 3.1e-43 148.0 0.4 7.1e-43 146.8 0.4 1.6 1 1 0 1 1 1 1 Putative transposase TrwC PF08751.11 CAV18728.1 - 0.0073 15.9 0.2 0.01 15.4 0.2 1.2 1 0 0 1 1 1 1 TrwC relaxase HTH_25 PF13413.6 CAV18728.1 - 0.06 13.2 0.0 0.12 12.3 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain DUF844 PF05815.11 CAV18728.1 - 0.17 11.1 0.0 0.8 8.8 0.0 1.9 1 1 1 2 2 2 0 Baculovirus protein of unknown function (DUF844) BPD_transp_1 PF00528.22 CAV18729.1 - 1.3e-13 51.1 13.2 1.3e-13 51.1 13.2 1.8 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component BPD_transp_1 PF00528.22 CAV18730.1 - 3.5e-21 75.8 13.6 4.6e-21 75.4 13.6 1.1 1 0 0 1 1 1 1 Binding-protein-dependent transport system inner membrane component SBP_bac_3 PF00497.20 CAV18731.1 - 1.3e-63 214.4 3.5 1.5e-63 214.2 3.5 1.0 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 Lig_chan-Glu_bd PF10613.9 CAV18731.1 - 4.5e-06 26.9 0.1 0.00043 20.5 0.1 2.5 1 1 0 1 1 1 1 Ligated ion channel L-glutamate- and glycine-binding site YhfZ_C PF14503.6 CAV18731.1 - 0.012 15.2 0.2 0.019 14.5 0.2 1.4 1 1 0 1 1 1 0 YhfZ C-terminal domain ABC_tran PF00005.27 CAV18732.1 - 1.5e-35 122.7 0.0 2e-35 122.3 0.0 1.2 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 CAV18732.1 - 1.3e-11 44.9 0.1 7.6e-06 25.9 0.0 2.1 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 CAV18732.1 - 1.7e-07 30.9 0.1 4.1e-07 29.7 0.1 1.6 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_15 PF13175.6 CAV18732.1 - 2.4e-06 27.5 0.0 0.066 12.9 0.0 2.1 1 1 0 2 2 2 2 AAA ATPase domain RsgA_GTPase PF03193.16 CAV18732.1 - 1.2e-05 25.3 0.3 3.2e-05 23.9 0.1 1.9 1 1 1 2 2 2 1 RsgA GTPase AAA_13 PF13166.6 CAV18732.1 - 1.2e-05 24.2 0.2 0.0018 17.0 0.0 2.0 1 1 0 2 2 2 2 AAA domain AAA_29 PF13555.6 CAV18732.1 - 0.0026 17.5 0.0 0.0049 16.6 0.0 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_16 PF13191.6 CAV18732.1 - 0.0041 17.5 0.5 0.0074 16.7 0.5 1.7 1 1 0 1 1 1 1 AAA ATPase domain IstB_IS21 PF01695.17 CAV18732.1 - 0.0057 16.4 0.0 0.17 11.6 0.0 2.2 2 0 0 2 2 2 1 IstB-like ATP binding protein AAA_23 PF13476.6 CAV18732.1 - 0.017 15.6 1.5 0.083 13.4 0.0 2.1 1 1 0 2 2 2 0 AAA domain AAA_22 PF13401.6 CAV18732.1 - 0.02 15.2 0.2 0.12 12.7 0.2 2.1 1 1 0 1 1 1 0 AAA domain AAA_30 PF13604.6 CAV18732.1 - 0.052 13.3 0.1 0.13 12.0 0.1 1.8 1 1 0 1 1 1 0 AAA domain AAA_18 PF13238.6 CAV18732.1 - 0.084 13.4 0.0 0.13 12.8 0.0 1.6 1 1 0 1 1 1 0 AAA domain AAA_5 PF07728.14 CAV18732.1 - 0.11 12.5 0.1 1.5 8.8 0.0 2.2 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) Antimicrobial20 PF08256.11 CAV18732.1 - 0.28 11.8 0.5 0.28 11.8 0.5 2.2 2 0 0 2 2 1 0 Aurein-like antibiotic peptide ABC_membrane PF00664.23 CAV18733.1 - 3.5e-48 164.6 18.3 4.5e-48 164.3 18.3 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 CAV18733.1 - 4.5e-32 111.4 0.0 9e-32 110.5 0.0 1.5 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 CAV18733.1 - 1.3e-06 28.1 0.1 0.00011 21.8 0.1 2.2 1 1 0 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 CAV18733.1 - 0.00012 22.3 0.4 0.0013 19.0 0.4 2.3 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 CAV18733.1 - 0.00029 21.3 0.3 0.0008 19.8 0.3 1.7 1 1 0 1 1 1 1 AAA ATPase domain RsgA_GTPase PF03193.16 CAV18733.1 - 0.0016 18.4 0.0 0.0064 16.4 0.0 2.0 2 0 0 2 2 2 1 RsgA GTPase AAA_21 PF13304.6 CAV18733.1 - 0.0026 17.6 0.3 0.023 14.5 0.0 2.1 1 1 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA PF00004.29 CAV18733.1 - 0.0026 18.2 0.4 0.047 14.1 0.4 2.5 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_30 PF13604.6 CAV18733.1 - 0.0031 17.2 0.0 0.014 15.1 0.0 2.0 2 0 0 2 2 2 1 AAA domain MPC PF03650.13 CAV18733.1 - 0.0072 16.4 0.0 0.016 15.4 0.0 1.5 1 0 0 1 1 1 1 Mitochondrial pyruvate carriers IstB_IS21 PF01695.17 CAV18733.1 - 0.028 14.2 0.1 4.1 7.1 0.0 2.4 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA_23 PF13476.6 CAV18733.1 - 0.029 14.9 0.0 0.075 13.5 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.6 CAV18733.1 - 0.031 14.0 0.0 0.074 12.8 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain Zeta_toxin PF06414.12 CAV18733.1 - 0.035 13.4 0.1 0.15 11.3 0.0 2.0 2 0 0 2 2 2 0 Zeta toxin ABC_ATPase PF09818.9 CAV18733.1 - 0.049 12.4 0.1 0.54 9.0 0.0 2.1 2 0 0 2 2 2 0 Predicted ATPase of the ABC class AAA_33 PF13671.6 CAV18733.1 - 0.059 13.5 0.0 0.21 11.7 0.0 2.1 1 0 0 1 1 1 0 AAA domain DEAD PF00270.29 CAV18733.1 - 0.063 13.0 0.0 0.22 11.3 0.0 2.0 1 1 0 1 1 1 0 DEAD/DEAH box helicase Rad17 PF03215.15 CAV18733.1 - 0.076 12.9 0.0 0.35 10.8 0.0 1.9 1 1 0 2 2 2 0 Rad17 P-loop domain AAA_5 PF07728.14 CAV18733.1 - 0.11 12.6 0.1 0.51 10.3 0.1 2.3 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) TsaE PF02367.17 CAV18733.1 - 0.15 12.1 0.0 0.32 11.0 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_18 PF13238.6 CAV18733.1 - 0.18 12.3 0.0 0.46 11.0 0.0 1.7 1 0 0 1 1 1 0 AAA domain S_4TM PF18159.1 CAV18733.1 - 0.82 8.9 3.0 0.85 8.9 0.1 2.2 1 1 1 2 2 2 0 SMODS-associating 4TM effector domain SbcCD_C PF13558.6 CAV18733.1 - 2 8.7 3.7 1.5 9.1 0.1 2.7 3 1 0 3 3 1 0 Putative exonuclease SbcCD, C subunit 4HBT_2 PF13279.6 CAV18734.1 - 1.5e-21 77.1 0.2 1.8e-21 76.9 0.2 1.1 1 0 0 1 1 1 1 Thioesterase-like superfamily 4HBT PF03061.22 CAV18734.1 - 5e-13 49.2 0.0 7.1e-13 48.7 0.0 1.2 1 0 0 1 1 1 1 Thioesterase superfamily Acyl-ACP_TE PF01643.17 CAV18734.1 - 0.00086 18.7 0.2 0.0037 16.6 0.1 1.9 1 1 1 2 2 2 1 Acyl-ACP thioesterase gpW PF02831.15 CAV18734.1 - 0.14 12.1 0.0 0.29 11.1 0.0 1.5 1 0 0 1 1 1 0 gpW Peptidase_U32 PF01136.19 CAV18735.1 - 2.1e-76 256.1 0.0 9.7e-68 227.8 0.0 2.3 2 0 0 2 2 2 2 Peptidase family U32 DUF3656 PF12392.8 CAV18735.1 - 0.00011 22.8 0.2 0.00026 21.6 0.2 1.6 1 0 0 1 1 1 1 Collagenase DUF2533 PF10752.9 CAV18735.1 - 0.72 10.3 2.5 2 8.9 0.1 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF2533) GST_C_2 PF13410.6 CAV18736.1 - 5.3e-13 48.8 0.0 8.6e-13 48.1 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 CAV18736.1 - 5.5e-13 49.1 0.0 1.4e-12 47.9 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 CAV18736.1 - 3.9e-08 33.5 0.0 7.6e-08 32.6 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 CAV18736.1 - 3.8e-07 30.2 0.0 5.8e-07 29.6 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_6 PF17171.4 CAV18736.1 - 0.0001 22.0 0.1 0.00025 20.7 0.1 1.7 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 CAV18736.1 - 0.0002 21.5 0.0 0.00033 20.8 0.0 1.5 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 CAV18736.1 - 0.00063 20.0 0.0 0.0045 17.3 0.0 2.1 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C_5 PF16865.5 CAV18736.1 - 0.015 15.8 0.0 0.024 15.2 0.0 1.3 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain GST_N_4 PF17172.4 CAV18736.1 - 0.037 14.8 0.3 0.32 11.7 0.0 2.4 2 1 1 3 3 3 0 Glutathione S-transferase N-terminal domain DUF2938 PF11158.8 CAV18736.1 - 0.11 11.9 0.0 2.7 7.5 0.0 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF2938) Patatin PF01734.22 CAV18737.1 - 2.6e-22 80.0 0.5 6.5e-22 78.7 0.5 1.7 1 1 0 1 1 1 1 Patatin-like phospholipase Glt_symporter PF03616.14 CAV18738.1 - 1.4e-119 399.1 20.7 1.7e-119 398.9 20.7 1.0 1 0 0 1 1 1 1 Sodium/glutamate symporter T_cell_tran_alt PF15128.6 CAV18738.1 - 0.017 14.9 0.3 0.059 13.2 0.1 2.0 2 0 0 2 2 2 0 T-cell leukemia translocation-altered RDV-p3 PF09231.10 CAV18738.1 - 0.055 11.2 0.2 0.078 10.7 0.2 1.1 1 0 0 1 1 1 0 Rice dwarf virus p3 Cass2 PF14526.6 CAV18739.1 - 3.1e-21 76.1 0.3 3.7e-21 75.9 0.3 1.1 1 0 0 1 1 1 1 Integron-associated effector binding protein GyrI-like PF06445.15 CAV18739.1 - 1.5e-13 51.4 0.1 1.7e-13 51.2 0.1 1.1 1 0 0 1 1 1 1 GyrI-like small molecule binding domain ROF PF07073.12 CAV18741.1 - 1.5e-29 102.0 1.1 1.7e-29 101.8 1.1 1.0 1 0 0 1 1 1 1 Modulator of Rho-dependent transcription termination (ROF) Cytochrome_CBB3 PF13442.6 CAV18742.1 - 5.2e-10 39.5 0.0 8.3e-10 38.8 0.0 1.3 1 0 0 1 1 1 1 Cytochrome C oxidase, cbb3-type, subunit III Cytochrom_C PF00034.21 CAV18742.1 - 3.1e-06 28.2 0.0 4.6e-06 27.7 0.0 1.3 1 0 0 1 1 1 1 Cytochrome c Hexapep PF00132.24 CAV18744.1 - 1.5e-12 46.7 8.7 1.7e-10 40.2 1.3 3.2 4 0 0 4 4 4 2 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 CAV18744.1 - 3.3e-06 26.7 3.2 5.8e-05 22.8 0.5 2.5 2 0 0 2 2 2 2 Hexapeptide repeat of succinyl-transferase adh_short_C2 PF13561.6 CAV18745.1 - 5.4e-57 193.0 0.1 6.5e-57 192.8 0.1 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CAV18745.1 - 1.5e-49 168.2 0.2 1.8e-49 167.8 0.2 1.0 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CAV18745.1 - 4.8e-16 59.2 0.2 6.6e-16 58.7 0.2 1.1 1 0 0 1 1 1 1 KR domain DUF1776 PF08643.10 CAV18745.1 - 0.0023 17.4 0.0 0.0026 17.2 0.0 1.1 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) Epimerase PF01370.21 CAV18745.1 - 0.0096 15.4 0.0 0.036 13.5 0.1 1.7 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family SnoaL_2 PF12680.7 CAV18746.1 - 4.4e-10 40.1 0.3 5.6e-10 39.8 0.3 1.1 1 0 0 1 1 1 1 SnoaL-like domain SnoaL PF07366.12 CAV18746.1 - 4.5e-05 23.3 0.2 0.00013 21.8 0.2 1.7 1 1 0 1 1 1 1 SnoaL-like polyketide cyclase SnoaL_3 PF13474.6 CAV18746.1 - 0.0027 17.9 0.4 0.0035 17.6 0.4 1.4 1 1 0 1 1 1 1 SnoaL-like domain LEH PF07858.12 CAV18746.1 - 0.012 15.8 0.0 0.013 15.6 0.0 1.2 1 0 0 1 1 1 0 Limonene-1,2-epoxide hydrolase catalytic domain DUF4440 PF14534.6 CAV18746.1 - 0.06 13.8 0.2 0.079 13.4 0.1 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4440) DUF4878 PF12870.7 CAV18746.1 - 0.15 12.4 0.0 0.19 12.0 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4878) HAD PF12710.7 CAV18747.1 - 5.2e-21 75.9 0.0 6.5e-21 75.6 0.0 1.1 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 CAV18747.1 - 1.1e-15 58.2 0.0 2e-15 57.3 0.0 1.4 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 CAV18747.1 - 7.2e-05 22.8 0.0 0.00017 21.6 0.0 1.6 1 1 0 1 1 1 1 HAD-hyrolase-like Hydrolase PF00702.26 CAV18747.1 - 0.017 15.4 0.0 0.69 10.2 0.0 2.2 1 1 0 1 1 1 0 haloacid dehalogenase-like hydrolase Trehalose_PPase PF02358.16 CAV18747.1 - 0.066 12.3 0.0 4.8 6.2 0.0 2.3 2 0 0 2 2 2 0 Trehalose-phosphatase SEC-C PF02810.15 CAV18748.1 - 9.6e-09 35.0 11.9 1.3e-08 34.5 11.9 1.2 1 0 0 1 1 1 1 SEC-C motif DUF302 PF03625.14 CAV18749.1 - 4.6e-21 74.5 0.0 6.8e-21 73.9 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function DUF302 Acetyltransf_7 PF13508.7 CAV18750.1 - 1.1e-09 38.6 0.2 1.7e-09 38.0 0.2 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 CAV18750.1 - 3.6e-08 33.7 0.0 4.4e-08 33.4 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 CAV18750.1 - 4.8e-08 33.0 0.3 1.1e-07 31.8 0.3 1.7 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_15 PF17013.5 CAV18750.1 - 0.051 13.0 0.0 0.051 13.0 0.0 1.2 1 0 0 1 1 1 0 Putative acetyl-transferase HD_3 PF13023.6 CAV18751.1 - 4.2e-47 160.1 0.1 4.9e-47 159.9 0.1 1.0 1 0 0 1 1 1 1 HD domain HD_2 PF12917.7 CAV18751.1 - 1.9e-14 53.8 0.1 2.5e-14 53.5 0.1 1.1 1 0 0 1 1 1 1 HD containing hydrolase-like enzyme HD PF01966.22 CAV18751.1 - 0.00068 19.9 0.1 0.0012 19.0 0.1 1.5 1 0 0 1 1 1 1 HD domain Glyoxalase PF00903.25 CAV18752.1 - 7e-19 68.3 0.0 9.9e-19 67.8 0.0 1.2 1 0 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_4 PF13669.6 CAV18752.1 - 8.4e-06 26.0 0.0 1.1e-05 25.7 0.0 1.1 1 0 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_6 PF18029.1 CAV18752.1 - 2.9e-05 24.8 0.0 6.2e-05 23.7 0.0 1.5 1 1 1 2 2 2 1 Glyoxalase-like domain LysE PF01810.18 CAV18753.1 - 2.7e-33 115.0 14.4 3.4e-33 114.7 14.4 1.0 1 0 0 1 1 1 1 LysE type translocator Acetyltransf_1 PF00583.25 CAV18754.1 - 9.4e-09 35.5 0.0 1.2e-08 35.2 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 CAV18754.1 - 1.8e-06 27.9 0.0 3.2e-06 27.1 0.0 1.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.6 CAV18754.1 - 1e-05 25.3 0.0 1.2e-05 25.1 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 CAV18754.1 - 1.4e-05 25.4 0.1 2.2e-05 24.8 0.1 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.7 CAV18754.1 - 0.0018 18.9 0.0 0.0024 18.5 0.0 1.3 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 CAV18754.1 - 0.0024 17.8 0.0 0.0038 17.2 0.0 1.5 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_1 PF00583.25 CAV18756.1 - 1.5e-14 54.2 0.0 1.8e-14 53.9 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 CAV18756.1 - 4e-14 52.6 0.0 4.8e-14 52.4 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 CAV18756.1 - 9e-12 45.3 0.1 1.3e-11 44.8 0.1 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 CAV18756.1 - 1.2e-05 25.1 0.0 1.7e-05 24.7 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein PanZ PF12568.8 CAV18756.1 - 0.00054 19.7 0.0 0.00058 19.6 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain, PanZ Acetyltransf_3 PF13302.7 CAV18756.1 - 0.0011 19.6 0.0 0.0016 19.1 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_6 PF13480.7 CAV18756.1 - 0.0042 17.2 0.0 0.0051 17.0 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 CAV18756.1 - 0.0049 17.0 0.0 0.0054 16.9 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 CAV18756.1 - 0.015 15.4 0.0 0.22 11.6 0.0 2.0 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 CAV18756.1 - 0.038 14.1 0.0 0.071 13.2 0.0 1.4 1 1 0 1 1 1 0 GCN5-related N-acetyl-transferase KORA PF16509.5 CAV18756.1 - 0.11 12.8 0.0 0.15 12.3 0.0 1.3 1 0 0 1 1 1 0 TrfB plasmid transcriptional repressor Glyoxalase PF00903.25 CAV18757.1 - 0.21 11.8 0.1 1.2 9.3 0.1 2.0 1 1 0 1 1 1 0 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily NUDIX PF00293.28 CAV18758.1 - 2e-24 86.1 0.3 2.3e-24 85.9 0.3 1.0 1 0 0 1 1 1 1 NUDIX domain NUDIX_4 PF14815.6 CAV18758.1 - 0.016 15.2 0.1 0.025 14.6 0.1 1.3 1 1 0 1 1 1 0 NUDIX domain Lactamase_B PF00753.27 CAV18759.1 - 2.1e-05 24.6 2.7 4.7e-05 23.5 0.6 2.1 2 0 0 2 2 2 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 CAV18759.1 - 5.7e-05 22.7 0.3 9.4e-05 22.0 0.3 1.4 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 CAV18759.1 - 0.001 19.0 0.0 0.0027 17.6 0.0 1.7 1 1 1 2 2 2 1 Beta-lactamase superfamily domain Acetyltransf_1 PF00583.25 CAV18760.1 - 2.6e-08 34.1 0.0 3.2e-08 33.8 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 CAV18760.1 - 8.5e-06 26.1 0.0 1.6e-05 25.2 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 CAV18760.1 - 0.00023 21.1 0.0 0.00042 20.2 0.0 1.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 CAV18760.1 - 0.0087 16.0 0.0 0.018 15.0 0.0 1.5 1 0 0 1 1 1 1 FR47-like protein RraA-like PF03737.15 CAV18761.1 - 2.4e-39 134.9 0.1 3.2e-39 134.5 0.1 1.2 1 0 0 1 1 1 1 Aldolase/RraA Epimerase PF01370.21 CAV18762.1 - 7.6e-05 22.3 0.0 0.00044 19.8 0.0 1.9 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family NmrA PF05368.13 CAV18762.1 - 0.0012 18.4 0.0 0.002 17.8 0.0 1.6 1 0 0 1 1 1 1 NmrA-like family RmlD_sub_bind PF04321.17 CAV18762.1 - 0.0078 15.4 0.0 0.05 12.7 0.0 2.0 1 1 0 1 1 1 1 RmlD substrate binding domain GDP_Man_Dehyd PF16363.5 CAV18762.1 - 0.054 12.9 0.0 0.5 9.7 0.0 2.0 2 0 0 2 2 2 0 GDP-mannose 4,6 dehydratase Alginate_exp PF13372.6 CAV18762.1 - 0.06 12.1 0.0 0.078 11.7 0.0 1.1 1 0 0 1 1 1 0 Alginate export GFA PF04828.14 CAV18767.1 - 1.3e-13 51.1 0.1 1.9e-13 50.5 0.1 1.3 1 0 0 1 1 1 1 Glutathione-dependent formaldehyde-activating enzyme Glyoxalase PF00903.25 CAV18768.1 - 1.1e-05 25.6 0.0 2.7e-05 24.4 0.0 1.5 1 1 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_2 PF12681.7 CAV18768.1 - 0.0011 18.9 0.5 0.009 15.9 0.5 2.0 1 1 0 1 1 1 1 Glyoxalase-like domain KaiB PF07689.12 CAV18768.1 - 0.11 12.3 0.0 0.16 11.8 0.0 1.2 1 0 0 1 1 1 0 KaiB domain PseudoU_synth_2 PF00849.22 CAV18769.1 - 4.7e-16 59.3 0.0 7.6e-16 58.6 0.0 1.4 1 0 0 1 1 1 1 RNA pseudouridylate synthase S4 PF01479.25 CAV18769.1 - 4.2e-06 26.4 0.0 8.7e-06 25.4 0.0 1.6 1 0 0 1 1 1 1 S4 domain zf-RRPl_C4 PF17026.5 CAV18770.1 - 0.04 14.0 0.6 0.05 13.7 0.6 1.3 1 1 0 1 1 1 0 Putative ribonucleoprotein zinc-finger pf C4 type CxxCxxCC PF03692.15 CAV18771.1 - 1.7e-07 31.8 3.0 3.6e-07 30.8 2.9 1.5 1 1 0 1 1 1 1 Putative zinc- or iron-chelating domain NUDIX PF00293.28 CAV18772.1 - 3.6e-12 46.5 0.0 4.6e-12 46.1 0.0 1.1 1 0 0 1 1 1 1 NUDIX domain NUDIX_2 PF13869.6 CAV18772.1 - 0.045 13.3 0.0 0.05 13.2 0.0 1.3 1 0 0 1 1 1 0 Nucleotide hydrolase SpoIIAA-like PF11964.8 CAV18773.1 - 5.6e-19 69.0 0.3 7.1e-19 68.7 0.3 1.0 1 0 0 1 1 1 1 SpoIIAA-like Methyltransf_11 PF08241.12 CAV18774.1 - 2.3e-09 37.8 0.0 3.4e-09 37.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CAV18774.1 - 6.3e-09 36.4 0.0 1.1e-08 35.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CAV18774.1 - 5.5e-08 32.8 0.0 9.8e-08 31.9 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain TehB PF03848.14 CAV18774.1 - 1.1e-06 28.2 0.0 1.5e-06 27.8 0.0 1.3 1 0 0 1 1 1 1 Tellurite resistance protein TehB Methyltransf_12 PF08242.12 CAV18774.1 - 6.8e-06 26.8 0.0 1.2e-05 25.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CAV18774.1 - 0.00013 21.9 0.0 0.00015 21.7 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain TPMT PF05724.11 CAV18774.1 - 0.032 13.9 0.0 0.048 13.3 0.0 1.3 1 0 0 1 1 1 0 Thiopurine S-methyltransferase (TPMT) AdoMet_MTase PF07757.13 CAV18774.1 - 0.033 14.5 0.0 0.069 13.5 0.0 1.6 1 0 0 1 1 1 0 Predicted AdoMet-dependent methyltransferase Pox_MCEL PF03291.16 CAV18774.1 - 0.07 12.2 0.0 1.1 8.3 0.0 2.0 1 1 1 2 2 2 0 mRNA capping enzyme MetW PF07021.12 CAV18774.1 - 0.17 11.4 0.0 0.23 11.0 0.0 1.2 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW HAD_2 PF13419.6 CAV18775.1 - 1.2e-08 35.3 0.0 1.5e-08 34.9 0.0 1.2 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 CAV18775.1 - 6.8e-07 29.3 0.0 2.1e-06 27.7 0.0 1.8 2 0 0 2 2 2 1 HAD-hyrolase-like Hydrolase PF00702.26 CAV18775.1 - 8.7e-05 22.9 0.0 0.00019 21.8 0.0 1.5 1 1 1 2 2 2 1 haloacid dehalogenase-like hydrolase Acetyltransf_4 PF13420.7 CAV18776.1 - 4.4e-15 56.2 0.2 4.9e-15 56.0 0.2 1.0 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 CAV18776.1 - 1.3e-10 41.5 0.1 1.8e-10 41.1 0.1 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 CAV18776.1 - 3.4e-08 33.5 0.1 4.2e-08 33.2 0.1 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.7 CAV18776.1 - 9.7e-08 32.8 0.0 1.2e-07 32.5 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 CAV18776.1 - 6.3e-07 29.7 0.1 8.9e-07 29.3 0.1 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 CAV18776.1 - 8.1e-05 22.7 0.1 0.00018 21.6 0.1 1.6 1 1 0 1 1 1 1 GCN5-related N-acetyl-transferase FR47 PF08445.10 CAV18776.1 - 0.0012 18.8 0.0 0.0019 18.1 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_9 PF13527.7 CAV18776.1 - 0.0027 17.8 0.0 0.0037 17.3 0.0 1.5 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.6 CAV18776.1 - 0.097 12.4 0.0 0.14 11.8 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain 2-Hacid_dh_C PF02826.19 CAV18777.1 - 3e-46 157.0 0.0 4.7e-46 156.4 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 CAV18777.1 - 3.4e-13 49.4 0.0 4.1e-13 49.1 0.0 1.1 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.15 CAV18777.1 - 1e-05 25.7 0.0 4.1e-05 23.8 0.0 1.8 2 0 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase IlvN PF07991.12 CAV18777.1 - 0.00014 21.5 0.4 0.0067 16.0 0.0 2.2 2 0 0 2 2 2 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain AdoHcyase_NAD PF00670.21 CAV18777.1 - 0.0011 19.0 0.0 0.0036 17.4 0.0 1.8 2 0 0 2 2 2 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain Gp_dh_N PF00044.24 CAV18777.1 - 0.078 13.3 0.0 0.18 12.2 0.0 1.7 1 0 0 1 1 1 0 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain ASCH PF04266.14 CAV18779.1 - 9.2e-25 87.3 0.2 1.1e-24 87.1 0.2 1.1 1 0 0 1 1 1 1 ASCH domain SSrecog PF03531.14 CAV18779.1 - 0.067 13.1 0.0 0.093 12.7 0.0 1.3 1 0 0 1 1 1 0 Structure-specific recognition protein (SSRP1) GDPD PF03009.17 CAV18781.1 - 1.3e-61 208.6 0.0 1.5e-61 208.4 0.0 1.0 1 0 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family MFS_1 PF07690.16 CAV18783.1 - 1.1e-55 188.9 26.8 2.1e-50 171.6 26.3 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 CAV18783.1 - 3.2e-08 32.9 28.2 4.7e-05 22.4 9.4 2.2 1 1 1 2 2 2 2 Sugar (and other) transporter Nuc_H_symport PF03825.16 CAV18783.1 - 0.12 11.3 19.3 0.02 13.9 1.5 3.4 3 1 0 3 3 3 0 Nucleoside H+ symporter NCE101 PF11654.8 CAV18783.1 - 1.2 8.9 5.7 0.54 10.0 0.2 2.6 2 0 0 2 2 2 0 Non-classical export protein 1 LPAM_1 PF08139.12 CAV18785.1 - 5.3e-05 23.5 1.3 8e-05 22.9 1.3 1.3 1 0 0 1 1 1 1 Prokaryotic membrane lipoprotein lipid attachment site OMP_b-brl PF13505.6 CAV18787.1 - 0.036 14.2 4.2 0.17 12.0 4.2 2.0 1 1 0 1 1 1 0 Outer membrane protein beta-barrel domain DUF3297 PF11730.8 CAV18788.1 - 6.8e-35 118.8 0.0 7.8e-35 118.6 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3297) Acetyltransf_7 PF13508.7 CAV18789.1 - 4.3e-08 33.5 0.0 5.8e-08 33.0 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 CAV18789.1 - 1.1e-07 32.1 0.0 1.4e-07 31.7 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 CAV18789.1 - 4.5e-05 23.4 0.0 6.6e-05 22.9 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 CAV18789.1 - 0.00024 21.2 0.0 0.00038 20.5 0.0 1.3 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase Acetyltransf_15 PF17013.5 CAV18789.1 - 0.00032 20.2 0.0 0.00038 20.0 0.0 1.2 1 0 0 1 1 1 1 Putative acetyl-transferase Acetyltransf_9 PF13527.7 CAV18789.1 - 0.0012 19.0 0.0 0.0021 18.1 0.0 1.5 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_13 PF13880.6 CAV18789.1 - 0.029 14.4 0.0 0.046 13.7 0.0 1.3 1 0 0 1 1 1 0 ESCO1/2 acetyl-transferase PcfJ PF14284.6 CAV18790.1 - 3.5e-11 43.2 0.0 6.9e-11 42.2 0.0 1.5 1 0 0 1 1 1 1 PcfJ-like protein Usp PF00582.26 CAV18792.1 - 2e-11 44.6 0.0 2.4e-11 44.3 0.0 1.1 1 0 0 1 1 1 1 Universal stress protein family Imm39 PF15568.6 CAV18792.1 - 0.084 13.0 0.1 0.11 12.6 0.1 1.2 1 0 0 1 1 1 0 Immunity protein 39 FAD_binding_7 PF03441.14 CAV18793.1 - 1.5e-39 135.6 0.4 2.9e-39 134.7 0.4 1.4 1 0 0 1 1 1 1 FAD binding domain of DNA photolyase DNA_photolyase PF00875.18 CAV18793.1 - 5e-16 59.1 0.0 8.3e-16 58.4 0.0 1.3 1 0 0 1 1 1 1 DNA photolyase DPRP PF04244.13 CAV18795.1 - 2.3e-67 227.1 2.4 3.8e-67 226.4 2.4 1.3 1 0 0 1 1 1 1 Deoxyribodipyrimidine photo-lyase-related protein DUF1289 PF06945.13 CAV18795.1 - 0.012 15.4 2.6 3.5 7.5 0.2 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1289) adh_short PF00106.25 CAV18797.1 - 4.4e-21 75.2 0.0 5.2e-21 75.0 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CAV18797.1 - 4.4e-13 49.3 0.0 5.7e-13 49.0 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.21 CAV18797.1 - 1.4e-05 24.7 0.0 2e-05 24.2 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 CAV18797.1 - 0.0052 16.2 0.0 0.0072 15.8 0.0 1.2 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase 3Beta_HSD PF01073.19 CAV18797.1 - 0.0061 15.6 0.0 0.0081 15.2 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family KR PF08659.10 CAV18797.1 - 0.0073 16.2 0.0 0.016 15.1 0.0 1.6 1 1 0 1 1 1 1 KR domain NAD_binding_10 PF13460.6 CAV18797.1 - 0.08 12.8 0.0 0.1 12.4 0.0 1.5 1 1 0 1 1 1 0 NAD(P)H-binding RIO1 PF01163.22 CAV18798.1 - 1e-40 139.4 0.0 1.6e-40 138.7 0.0 1.3 1 0 0 1 1 1 1 RIO1 family APH PF01636.23 CAV18798.1 - 3.7e-05 23.8 1.0 0.003 17.5 0.1 2.6 1 1 2 3 3 3 2 Phosphotransferase enzyme family YrbL-PhoP_reg PF10707.9 CAV18798.1 - 0.0088 15.6 0.3 0.037 13.5 0.3 2.1 1 1 0 1 1 1 1 PhoP regulatory network protein YrbL TetR_C_19 PF17924.1 CAV18798.1 - 0.12 13.0 0.1 0.35 11.5 0.0 1.8 1 1 1 2 2 2 0 Tetracyclin repressor-like, C-terminal domain SapB_2 PF03489.17 CAV18798.1 - 0.12 12.5 0.1 0.33 11.1 0.1 1.8 1 0 0 1 1 1 0 Saposin-like type B, region 2 DUF2256 PF10013.9 CAV18800.1 - 4.4e-21 74.7 15.2 5e-21 74.5 15.2 1.0 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2256) zf-MYND PF01753.18 CAV18800.1 - 0.0079 16.3 6.1 0.013 15.6 6.1 1.5 1 1 0 1 1 1 1 MYND finger Ecl1 PF12855.7 CAV18800.1 - 0.0088 17.2 0.6 0.01 17.0 0.6 1.2 1 0 0 1 1 1 1 ECL1/2/3 zinc binding proteins YacG PF03884.14 CAV18800.1 - 0.12 12.1 9.2 0.31 10.8 9.2 1.7 1 1 0 1 1 1 0 DNA gyrase inhibitor YacG AAA_23 PF13476.6 CAV18804.1 - 1.6e-26 94.1 11.9 1.6e-26 94.1 11.9 7.6 1 1 2 3 3 3 1 AAA domain SbcCD_C PF13558.6 CAV18804.1 - 6.5e-15 55.1 0.1 2.1e-14 53.5 0.1 2.0 1 0 0 1 1 1 1 Putative exonuclease SbcCD, C subunit AAA_29 PF13555.6 CAV18804.1 - 1.4e-06 28.0 0.0 5.6e-06 26.0 0.0 2.0 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_21 PF13304.6 CAV18804.1 - 0.004 17.0 0.0 0.02 14.7 0.0 2.3 1 0 0 1 1 1 1 AAA domain, putative AbiEii toxin, Type IV TA system ABC_tran PF00005.27 CAV18804.1 - 0.013 16.0 0.0 0.013 16.0 0.0 6.7 3 2 0 3 3 3 0 ABC transporter SMC_N PF02463.19 CAV18804.1 - 0.017 14.6 0.0 0.017 14.6 0.0 3.1 2 1 0 2 2 2 0 RecF/RecN/SMC N terminal domain DUF1192 PF06698.11 CAV18804.1 - 2.5 8.2 9.0 26 4.9 2.3 4.0 3 0 0 3 3 3 0 Protein of unknown function (DUF1192) SbcD_C PF12320.8 CAV18805.1 - 2.4e-27 95.1 2.6 4.6e-27 94.1 2.6 1.5 1 0 0 1 1 1 1 Type 5 capsule protein repressor C-terminal domain Metallophos PF00149.28 CAV18805.1 - 5.7e-13 49.8 0.8 1.3e-12 48.7 0.8 1.6 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 CAV18805.1 - 2.7e-11 43.9 0.0 4.4e-09 36.7 0.0 2.5 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain OMP_b-brl PF13505.6 CAV18807.1 - 8.4e-24 84.7 10.1 1.1e-23 84.3 10.1 1.0 1 0 0 1 1 1 1 Outer membrane protein beta-barrel domain OmpA_membrane PF01389.17 CAV18807.1 - 2e-10 40.7 2.1 2.8e-10 40.2 2.1 1.2 1 0 0 1 1 1 1 OmpA-like transmembrane domain GST_N_3 PF13417.6 CAV18809.1 - 6e-21 74.6 0.0 5.4e-20 71.6 0.0 2.0 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 CAV18809.1 - 4.1e-17 62.2 0.0 3.3e-16 59.3 0.0 2.1 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.20 CAV18809.1 - 1e-14 54.6 0.0 2.7e-14 53.3 0.0 1.7 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_N_4 PF17172.4 CAV18809.1 - 8.6e-08 32.8 0.0 3.3e-07 31.0 0.0 1.9 2 0 0 2 2 2 1 Glutathione S-transferase N-terminal domain GST_C PF00043.25 CAV18809.1 - 1.2e-07 31.8 0.1 1.8e-07 31.2 0.1 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Tom37 PF10568.9 CAV18809.1 - 1.2e-06 28.8 0.0 2.1e-06 28.1 0.0 1.4 1 0 0 1 1 1 1 Outer mitochondrial membrane transport complex protein GST_C_2 PF13410.6 CAV18809.1 - 9.7e-06 25.5 0.0 1.8e-05 24.7 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 CAV18809.1 - 0.0038 17.4 0.1 0.0072 16.5 0.1 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_5 PF16865.5 CAV18809.1 - 0.0048 17.4 0.0 0.008 16.7 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Glutaredoxin PF00462.24 CAV18809.1 - 0.13 12.5 0.0 0.45 10.8 0.0 1.9 2 0 0 2 2 2 0 Glutaredoxin LysE PF01810.18 CAV18811.1 - 3.8e-40 137.4 11.8 4.3e-40 137.2 11.8 1.0 1 0 0 1 1 1 1 LysE type translocator YmcE_antitoxin PF15939.5 CAV18811.1 - 0.32 11.2 0.1 0.32 11.2 0.1 1.9 2 0 0 2 2 2 0 Putative antitoxin of bacterial toxin-antitoxin system Acetyltransf_1 PF00583.25 CAV18812.1 - 5.1e-13 49.3 0.0 6.2e-13 49.0 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 CAV18812.1 - 4.7e-08 33.4 0.0 7.3e-08 32.7 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 CAV18812.1 - 3e-07 30.4 0.0 3.7e-07 30.1 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain PanZ PF12568.8 CAV18812.1 - 0.00012 21.8 0.0 0.00013 21.6 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain, PanZ Acetyltransf_CG PF14542.6 CAV18812.1 - 0.0035 17.4 0.0 0.0058 16.7 0.0 1.3 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase Acetyltransf_4 PF13420.7 CAV18812.1 - 0.012 15.7 0.0 0.014 15.5 0.0 1.1 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain FR47 PF08445.10 CAV18812.1 - 0.02 14.9 0.0 0.03 14.3 0.0 1.3 1 0 0 1 1 1 0 FR47-like protein PUF PF00806.19 CAV18812.1 - 0.04 13.6 0.0 0.34 10.7 0.0 2.2 2 0 0 2 2 2 0 Pumilio-family RNA binding repeat Acetyltransf_9 PF13527.7 CAV18812.1 - 0.044 13.9 0.1 0.18 11.9 0.0 2.1 1 1 0 2 2 2 0 Acetyltransferase (GNAT) domain GGDEF PF00990.21 CAV18814.1 - 5.6e-33 114.0 0.1 1.3e-32 112.8 0.1 1.7 1 1 0 1 1 1 1 Diguanylate cyclase, GGDEF domain PAS_3 PF08447.12 CAV18814.1 - 3.5e-07 30.4 0.0 0.015 15.5 0.0 2.6 2 0 0 2 2 2 2 PAS fold PAS_8 PF13188.7 CAV18814.1 - 1.6e-05 24.8 0.0 0.0029 17.6 0.0 3.0 3 0 0 3 3 3 1 PAS domain PAS PF00989.25 CAV18814.1 - 0.0015 18.5 0.0 0.22 11.5 0.0 2.7 2 0 0 2 2 2 2 PAS fold Methyltransf_25 PF13649.6 CAV18815.1 - 8.3e-13 48.9 0.0 2.5e-12 47.3 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 CAV18815.1 - 3.2e-12 46.9 0.0 8.2e-12 45.6 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 CAV18815.1 - 2.5e-10 40.4 0.0 3.3e-10 40.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CAV18815.1 - 1.1e-09 38.3 0.0 1.6e-09 37.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CAV18815.1 - 4.6e-08 33.7 0.0 1.2e-07 32.4 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain CMAS PF02353.20 CAV18815.1 - 0.00021 20.7 0.0 0.00028 20.3 0.0 1.1 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Ubie_methyltran PF01209.18 CAV18815.1 - 0.0059 16.0 0.0 0.0099 15.2 0.0 1.4 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family NodS PF05401.11 CAV18815.1 - 0.0065 16.1 0.0 0.014 15.1 0.0 1.5 2 0 0 2 2 2 1 Nodulation protein S (NodS) N6_N4_Mtase PF01555.18 CAV18815.1 - 0.021 14.5 0.0 0.049 13.3 0.0 1.7 2 0 0 2 2 2 0 DNA methylase Methyltransf_9 PF08003.11 CAV18815.1 - 0.05 12.5 0.0 0.078 11.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1698) TehB PF03848.14 CAV18815.1 - 0.094 12.1 0.0 0.23 10.8 0.0 1.7 1 1 0 1 1 1 0 Tellurite resistance protein TehB TonB_dep_Rec PF00593.24 CAV18817.1 - 1.2e-52 180.4 23.6 1.7e-52 179.9 23.6 1.2 1 0 0 1 1 1 1 TonB dependent receptor Plug PF07715.15 CAV18817.1 - 4.3e-27 94.8 1.5 1.1e-26 93.5 1.5 1.7 1 0 0 1 1 1 1 TonB-dependent Receptor Plug Domain OMP_b-brl_3 PF14905.6 CAV18817.1 - 2.5e-09 36.6 1.2 2.5e-09 36.6 1.2 2.7 3 0 0 3 3 3 1 Outer membrane protein beta-barrel family OMP_b-brl PF13505.6 CAV18817.1 - 2.2 8.4 13.9 0.083 13.0 2.5 3.5 2 2 2 4 4 4 0 Outer membrane protein beta-barrel domain LysR_substrate PF03466.20 CAV18818.1 - 4.2e-18 65.5 0.0 6.3e-18 64.9 0.0 1.2 1 0 0 1 1 1 1 LysR substrate binding domain HTH_1 PF00126.27 CAV18818.1 - 5.1e-13 48.8 0.1 1.8e-12 47.0 0.0 2.0 2 0 0 2 2 2 1 Bacterial regulatory helix-turn-helix protein, lysR family HTH_5 PF01022.20 CAV18818.1 - 0.00017 21.4 0.9 0.00039 20.2 0.9 1.6 1 0 0 1 1 1 1 Bacterial regulatory protein, arsR family HTH_24 PF13412.6 CAV18818.1 - 0.045 13.3 0.6 0.18 11.4 0.2 2.2 2 1 0 2 2 2 0 Winged helix-turn-helix DNA-binding DHHA1 PF02272.19 CAV18820.1 - 0.0052 17.2 0.0 0.013 15.9 0.0 1.7 2 0 0 2 2 2 1 DHHA1 domain DHH PF01368.20 CAV18820.1 - 0.0057 16.9 0.1 0.01 16.0 0.1 1.4 1 0 0 1 1 1 1 DHH family MCPsignal PF00015.21 CAV18821.1 - 4.2e-41 140.6 21.6 4.2e-41 140.6 21.6 3.4 1 1 1 2 2 2 2 Methyl-accepting chemotaxis protein (MCP) signalling domain HAMP PF00672.25 CAV18821.1 - 1.7e-09 37.9 0.3 2.4e-08 34.2 0.0 3.3 4 0 0 4 4 3 1 HAMP domain CENP-Q PF13094.6 CAV18821.1 - 0.0001 22.5 2.8 0.0001 22.5 2.8 3.7 3 1 2 5 5 5 1 CENP-Q, a CENPA-CAD centromere complex subunit Taxilin PF09728.9 CAV18821.1 - 0.0078 15.4 0.7 0.0078 15.4 0.7 2.6 3 0 0 3 3 3 1 Myosin-like coiled-coil protein IFT57 PF10498.9 CAV18821.1 - 0.0084 15.1 2.3 0.0084 15.1 2.3 2.8 2 1 0 2 2 2 1 Intra-flagellar transport protein 57 Orai-1 PF07856.12 CAV18821.1 - 0.025 14.3 0.2 0.056 13.1 0.2 1.7 1 0 0 1 1 1 0 Mediator of CRAC channel activity T7SS_ESX_EspC PF10824.8 CAV18821.1 - 0.14 12.7 20.5 0.04 14.4 1.8 5.2 1 1 4 5 5 5 0 Excreted virulence factor EspC, type VII ESX diderm BLOC1_2 PF10046.9 CAV18821.1 - 0.32 11.3 26.0 5.3 7.4 0.1 5.7 4 2 2 6 6 6 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Med29 PF11568.8 CAV18821.1 - 0.61 10.3 8.0 0.46 10.7 0.3 4.2 4 1 0 4 4 4 0 Mediator complex subunit 29 IZUMO PF15005.6 CAV18821.1 - 2 9.0 6.5 20 5.7 0.2 3.0 3 0 0 3 3 2 0 Izumo sperm-egg fusion, Ig domain-associated Spc7 PF08317.11 CAV18821.1 - 3.4 6.4 17.1 0.36 9.7 3.2 3.0 1 1 0 2 2 2 0 Spc7 kinetochore protein CC2-LZ PF16516.5 CAV18821.1 - 4.2 7.8 8.9 3.6 8.0 0.3 3.7 3 1 1 4 4 4 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator V_ATPase_I PF01496.19 CAV18821.1 - 4.9 5.0 14.0 15 3.4 14.0 1.8 1 1 0 1 1 1 0 V-type ATPase 116kDa subunit family Seryl_tRNA_N PF02403.22 CAV18821.1 - 5 7.4 15.1 0.94 9.7 0.5 5.0 3 1 2 5 5 5 0 Seryl-tRNA synthetase N-terminal domain MarR PF01047.22 CAV18822.1 - 1.2e-14 54.0 0.1 2.3e-14 53.0 0.1 1.5 1 0 0 1 1 1 1 MarR family MarR_2 PF12802.7 CAV18822.1 - 2e-11 43.6 0.1 3.5e-11 42.8 0.1 1.4 1 0 0 1 1 1 1 MarR family HTH_27 PF13463.6 CAV18822.1 - 1.3e-07 32.0 1.6 1.6e-07 31.7 0.5 1.7 2 0 0 2 2 2 1 Winged helix DNA-binding domain HTH_24 PF13412.6 CAV18822.1 - 9.4e-07 28.3 0.1 2.9e-06 26.7 0.1 1.9 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding HxlR PF01638.17 CAV18822.1 - 5.6e-06 26.1 1.0 1.2e-05 25.1 0.2 1.9 2 0 0 2 2 2 1 HxlR-like helix-turn-helix HTH_34 PF13601.6 CAV18822.1 - 7.1e-06 26.1 0.1 1.5e-05 25.0 0.1 1.5 1 0 0 1 1 1 1 Winged helix DNA-binding domain HTH_20 PF12840.7 CAV18822.1 - 0.0016 18.5 0.2 0.0035 17.4 0.2 1.6 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_Crp_2 PF13545.6 CAV18822.1 - 0.0039 17.1 0.3 0.016 15.2 0.1 2.0 2 0 0 2 2 2 1 Crp-like helix-turn-helix domain Cnd3 PF12719.7 CAV18822.1 - 0.0077 15.5 1.6 0.0098 15.1 1.6 1.1 1 0 0 1 1 1 1 Nuclear condensing complex subunits, C-term domain RP-C PF03428.13 CAV18822.1 - 0.0095 15.6 0.0 0.017 14.8 0.0 1.4 1 0 0 1 1 1 1 Replication protein C N-terminal domain HTH_DeoR PF08220.12 CAV18822.1 - 0.011 15.4 0.2 0.028 14.2 0.2 1.6 1 0 0 1 1 1 0 DeoR-like helix-turn-helix domain HTH_5 PF01022.20 CAV18822.1 - 0.011 15.6 0.0 0.036 13.9 0.1 1.9 2 0 0 2 2 1 0 Bacterial regulatory protein, arsR family TFIIE_alpha PF02002.17 CAV18822.1 - 0.014 15.2 1.4 0.21 11.5 0.1 2.6 3 0 0 3 3 3 0 TFIIE alpha subunit TrmB PF01978.19 CAV18822.1 - 0.023 14.6 0.0 0.043 13.7 0.0 1.4 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB HTH_1 PF00126.27 CAV18822.1 - 0.038 13.9 0.1 0.1 12.6 0.1 1.7 1 0 0 1 1 1 0 Bacterial regulatory helix-turn-helix protein, lysR family Fe_dep_repress PF01325.19 CAV18822.1 - 0.075 13.2 0.1 0.17 12.1 0.1 1.7 1 0 0 1 1 1 0 Iron dependent repressor, N-terminal DNA binding domain GntR PF00392.21 CAV18822.1 - 0.08 12.6 0.7 0.14 11.8 0.2 1.6 2 0 0 2 2 2 0 Bacterial regulatory proteins, gntR family HTH_11 PF08279.12 CAV18822.1 - 0.087 12.8 0.2 0.26 11.3 0.1 1.9 2 0 0 2 2 1 0 HTH domain Cullin_Nedd8 PF10557.9 CAV18822.1 - 2.4 8.3 6.8 7.1 6.7 0.0 3.2 3 1 0 3 3 3 0 Cullin protein neddylation domain Cation_efflux PF01545.21 CAV18823.1 - 8.3e-35 120.3 16.8 1.6e-34 119.4 16.8 1.4 1 1 0 1 1 1 1 Cation efflux family Zip PF02535.22 CAV18823.1 - 0.00013 21.4 5.7 0.00027 20.3 5.7 1.6 1 0 0 1 1 1 1 ZIP Zinc transporter Sulfatase PF00884.23 CAV18824.1 - 1.4e-58 198.7 0.1 1.8e-58 198.4 0.1 1.1 1 0 0 1 1 1 1 Sulfatase Phosphodiest PF01663.22 CAV18824.1 - 0.00045 19.9 0.5 0.011 15.3 0.5 2.3 1 1 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase_C PF14707.6 CAV18824.1 - 0.002 18.8 0.0 0.004 17.9 0.0 1.5 1 0 0 1 1 1 1 C-terminal region of aryl-sulfatase Bys1 PF04681.12 CAV18824.1 - 0.061 13.3 0.0 0.13 12.2 0.0 1.5 1 0 0 1 1 1 0 Blastomyces yeast-phase-specific protein LysR_substrate PF03466.20 CAV18825.1 - 4.4e-16 58.9 0.0 5.7e-16 58.5 0.0 1.1 1 0 0 1 1 1 1 LysR substrate binding domain HTH_1 PF00126.27 CAV18825.1 - 8.9e-12 44.8 0.0 1.7e-11 43.9 0.0 1.5 1 0 0 1 1 1 1 Bacterial regulatory helix-turn-helix protein, lysR family Cro PF09048.10 CAV18825.1 - 0.0025 17.8 0.0 0.006 16.6 0.0 1.6 1 0 0 1 1 1 1 Cro HTH_5 PF01022.20 CAV18825.1 - 0.053 13.4 0.0 0.11 12.3 0.0 1.5 1 0 0 1 1 1 0 Bacterial regulatory protein, arsR family MarR_2 PF12802.7 CAV18825.1 - 0.11 12.4 0.0 0.26 11.2 0.0 1.6 2 0 0 2 2 2 0 MarR family LysR_substrate PF03466.20 CAV18826.1 - 1.3e-25 90.0 0.0 1.7e-24 86.4 0.0 2.3 2 1 0 2 2 2 1 LysR substrate binding domain HTH_1 PF00126.27 CAV18826.1 - 6.8e-17 61.2 0.5 1.9e-16 59.7 0.1 2.0 2 0 0 2 2 2 1 Bacterial regulatory helix-turn-helix protein, lysR family HTH_5 PF01022.20 CAV18826.1 - 0.0014 18.5 0.1 0.003 17.4 0.1 1.5 1 0 0 1 1 1 1 Bacterial regulatory protein, arsR family Adenylsucc_synt PF00709.21 CAV18827.1 - 3.9e-134 447.7 0.0 4.5e-134 447.5 0.0 1.0 1 0 0 1 1 1 1 Adenylosuccinate synthetase NERD PF08378.11 CAV18828.1 - 1.4e-13 51.3 0.0 8.7e-13 48.7 0.0 2.2 2 0 0 2 2 2 1 Nuclease-related domain AAA_19 PF13245.6 CAV18828.1 - 5.6e-07 30.0 0.0 3.8e-06 27.3 0.0 2.0 2 0 0 2 2 2 1 AAA domain UvrD_C_2 PF13538.6 CAV18828.1 - 4.4e-06 26.4 0.0 1.3e-05 24.9 0.0 1.9 2 0 0 2 2 1 1 UvrD-like helicase C-terminal domain AAA_12 PF13087.6 CAV18828.1 - 1.1e-05 25.2 0.0 1.8e-05 24.5 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 CAV18828.1 - 7.6e-05 22.5 0.0 0.00012 21.8 0.0 1.3 1 0 0 1 1 1 1 AAA domain UvrD_C PF13361.6 CAV18828.1 - 0.00032 20.2 0.0 0.61 9.4 0.0 2.2 1 1 1 2 2 2 2 UvrD-like helicase C-terminal domain ResIII PF04851.15 CAV18828.1 - 0.00037 20.5 0.1 0.0014 18.7 0.1 1.8 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 CAV18828.1 - 0.00082 19.7 0.0 0.0077 16.5 0.0 2.3 2 0 0 2 2 2 1 AAA domain Viral_helicase1 PF01443.18 CAV18828.1 - 0.0012 18.6 0.0 1.6 8.4 0.0 2.5 2 1 0 2 2 2 2 Viral (Superfamily 1) RNA helicase IstB_IS21 PF01695.17 CAV18828.1 - 0.0023 17.7 0.0 0.0046 16.7 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein DUF2075 PF09848.9 CAV18828.1 - 0.0031 16.8 0.0 0.013 14.8 0.0 1.8 1 1 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) NACHT PF05729.12 CAV18828.1 - 0.0057 16.6 0.1 0.014 15.3 0.1 1.7 1 0 0 1 1 1 1 NACHT domain UvrD-helicase PF00580.21 CAV18828.1 - 0.008 15.7 2.7 0.11 12.0 0.2 2.9 2 1 0 3 3 3 1 UvrD/REP helicase N-terminal domain PhoH PF02562.16 CAV18828.1 - 0.018 14.5 0.2 0.05 13.1 0.1 1.7 2 0 0 2 2 2 0 PhoH-like protein AAA_16 PF13191.6 CAV18828.1 - 0.13 12.7 0.0 0.24 11.8 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain DSBA PF01323.20 CAV18828.1 - 0.14 11.9 0.0 0.23 11.2 0.0 1.3 1 0 0 1 1 1 0 DSBA-like thioredoxin domain PLDc_2 PF13091.6 CAV18829.1 - 2.3e-17 63.1 0.1 4.2e-17 62.3 0.1 1.4 1 0 0 1 1 1 1 PLD-like domain Auxin_resp PF06507.13 CAV18829.1 - 0.021 15.1 0.0 0.11 12.7 0.0 2.2 2 0 0 2 2 2 0 Auxin response factor PP_kinase_C PF13090.6 CAV18829.1 - 0.057 12.9 0.4 1.1 8.7 0.0 2.6 3 0 0 3 3 3 0 Polyphosphate kinase C-terminal domain 2 PLDc PF00614.22 CAV18829.1 - 0.074 13.3 0.0 0.17 12.2 0.0 1.6 1 0 0 1 1 1 0 Phospholipase D Active site motif HTH_57 PF18679.1 CAV18829.1 - 0.19 12.0 0.9 5.6 7.3 0.1 2.4 2 0 0 2 2 2 0 ThcOx helix turn helix domain DUF1998 PF09369.10 CAV18830.1 - 2.5e-10 41.0 0.8 4.9e-10 40.0 0.8 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1998) RPA_interact_C PF14768.6 CAV18830.1 - 0.0094 16.5 2.6 1.3 9.7 0.0 2.6 2 0 0 2 2 2 2 Replication protein A interacting C-terminal Helicase_C PF00271.31 CAV18831.1 - 1.7e-05 25.1 0.0 4.7e-05 23.7 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Lar_restr_allev PF14354.6 CAV18831.1 - 0.083 13.3 0.4 0.18 12.2 0.4 1.6 1 0 0 1 1 1 0 Restriction alleviation protein Lar N6_Mtase PF02384.16 CAV18832.1 - 1.3e-05 24.6 0.0 0.0028 17.0 0.0 2.8 2 1 0 2 2 2 2 N-6 DNA Methylase Helicase_C PF00271.31 CAV18833.1 - 2.2e-18 66.6 0.6 1.8e-16 60.5 0.0 3.1 3 0 0 3 3 3 1 Helicase conserved C-terminal domain SNF2_N PF00176.23 CAV18833.1 - 7e-16 57.9 0.7 1.8e-14 53.3 0.7 2.8 1 1 0 1 1 1 1 SNF2 family N-terminal domain ResIII PF04851.15 CAV18833.1 - 1.9e-06 28.0 4.6 2.5e-06 27.6 0.0 3.2 3 1 0 3 3 3 1 Type III restriction enzyme, res subunit Helicase_C_2 PF13307.6 CAV18833.1 - 2.8e-06 27.6 0.0 1e-05 25.8 0.0 1.9 1 0 0 1 1 1 1 Helicase C-terminal domain DEAD PF00270.29 CAV18833.1 - 0.00068 19.5 0.3 0.029 14.2 0.0 3.2 2 1 0 2 2 2 1 DEAD/DEAH box helicase AAA_34 PF13872.6 CAV18833.1 - 0.008 15.1 0.5 0.07 12.0 0.0 2.6 2 1 0 2 2 2 1 P-loop containing NTP hydrolase pore-1 DNA_methylase PF00145.17 CAV18834.1 - 1.4e-51 175.9 0.0 1.6e-51 175.7 0.0 1.0 1 0 0 1 1 1 1 C-5 cytosine-specific DNA methylase UvrD-helicase PF00580.21 CAV18835.1 - 6e-35 121.3 0.7 6.9e-34 117.8 0.7 2.2 1 1 0 1 1 1 1 UvrD/REP helicase N-terminal domain AAA_19 PF13245.6 CAV18835.1 - 1e-25 90.8 0.0 2.8e-25 89.3 0.0 1.8 1 1 0 1 1 1 1 AAA domain UvrD_C PF13361.6 CAV18835.1 - 1.4e-12 47.7 0.2 1.2e-11 44.6 0.0 2.3 2 1 0 2 2 2 1 UvrD-like helicase C-terminal domain zf-C4_Topoisom PF01396.19 CAV18835.1 - 2.1e-10 40.2 21.3 6.2e-07 29.1 4.1 3.1 1 1 2 3 3 3 2 Topoisomerase DNA binding C4 zinc finger UvrD_C_2 PF13538.6 CAV18835.1 - 9.7e-08 31.7 0.3 9.2e-05 22.2 0.1 2.6 2 0 0 2 2 2 2 UvrD-like helicase C-terminal domain AAA_30 PF13604.6 CAV18835.1 - 8.6e-06 25.6 0.0 0.0011 18.8 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_12 PF13087.6 CAV18835.1 - 0.00085 19.0 0.0 0.0017 18.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain Zn_ribbon_recom PF13408.6 CAV18835.1 - 0.0067 16.9 13.2 0.04 14.4 5.1 2.7 2 0 0 2 2 2 2 Recombinase zinc beta ribbon domain Phage_endo_I PF05367.11 CAV18835.1 - 0.025 14.2 0.2 0.084 12.5 0.1 1.9 2 0 0 2 2 2 0 Phage endonuclease I Rhodanese_C PF12368.8 CAV18835.1 - 0.099 13.0 8.2 0.055 13.8 6.0 1.7 1 1 0 1 1 1 0 Rhodanase C-terminal zf-ribbon_3 PF13248.6 CAV18835.1 - 2.1 7.9 6.9 15 5.1 0.3 3.5 3 0 0 3 3 3 0 zinc-ribbon domain HNH_2 PF13391.6 CAV18836.1 - 2.7e-07 30.6 0.1 1.5e-06 28.2 0.0 2.3 2 1 0 2 2 2 1 HNH endonuclease Methyltransf_23 PF13489.6 CAV18837.1 - 1e-08 35.2 0.0 2.3e-08 34.0 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CAV18837.1 - 5.7e-08 33.3 0.0 1.3e-07 32.2 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CAV18837.1 - 1.8e-07 31.8 0.0 4.2e-07 30.6 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CAV18837.1 - 2.8e-07 31.1 0.0 7.7e-07 29.7 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain TehB PF03848.14 CAV18837.1 - 8.5e-06 25.3 0.0 4.7e-05 22.9 0.0 1.9 1 1 0 2 2 2 1 Tellurite resistance protein TehB Methyltransf_31 PF13847.6 CAV18837.1 - 0.002 18.0 0.4 0.012 15.4 0.1 2.2 2 1 0 2 2 2 1 Methyltransferase domain TPMT PF05724.11 CAV18837.1 - 0.0061 16.2 0.0 2.1 8.0 0.0 2.1 2 0 0 2 2 2 2 Thiopurine S-methyltransferase (TPMT) DUF1564 PF07600.11 CAV18837.1 - 0.026 14.2 0.0 0.039 13.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1564) RrnaAD PF00398.20 CAV18837.1 - 0.079 12.0 0.0 0.099 11.7 0.0 1.2 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase RNase_H PF00075.24 CAV18838.1 - 6.3e-14 52.4 0.0 6.9e-14 52.2 0.0 1.1 1 0 0 1 1 1 1 RNase H Phage_AlpA PF05930.12 CAV18839.1 - 1.5e-22 79.1 0.1 2.1e-22 78.7 0.1 1.2 1 0 0 1 1 1 1 Prophage CP4-57 regulatory protein (AlpA) HTH_17 PF12728.7 CAV18839.1 - 0.00075 19.6 0.0 0.00094 19.3 0.0 1.2 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_IclR PF09339.10 CAV18839.1 - 0.058 13.2 0.0 0.098 12.5 0.0 1.3 1 0 0 1 1 1 0 IclR helix-turn-helix domain RadC PF04002.15 CAV18840.1 - 6.9e-44 148.7 0.0 9.2e-44 148.3 0.0 1.1 1 0 0 1 1 1 1 RadC-like JAB domain Prok-JAB PF14464.6 CAV18840.1 - 0.0017 18.1 0.1 0.002 17.9 0.1 1.3 1 1 0 1 1 1 1 Prokaryotic homologs of the JAB domain PA PF02225.22 CAV18840.1 - 0.034 14.2 0.0 0.048 13.7 0.0 1.3 1 0 0 1 1 1 0 PA domain Peptidase_C98 PF15499.6 CAV18840.1 - 0.18 11.3 0.0 0.26 10.7 0.0 1.1 1 0 0 1 1 1 0 Ubiquitin-specific peptidase-like, SUMO isopeptidase DUF2787 PF10980.8 CAV18841.1 - 3.5e-42 143.7 0.6 4e-42 143.5 0.6 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2787) DUF2787 PF10980.8 CAV18842.1 - 7e-50 168.6 0.4 7.9e-50 168.4 0.4 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2787) Styelin PF17562.2 CAV18843.1 - 0.05 14.0 0.1 0.074 13.4 0.1 1.3 1 0 0 1 1 1 0 Styelin Nup54_57_C PF18570.1 CAV18843.1 - 0.06 12.9 1.1 0.1 12.2 0.2 1.8 2 0 0 2 2 2 0 NUP57/Nup54 C-terminal domain Phage_Arf PF17585.2 CAV18844.1 - 0.14 12.1 0.0 0.27 11.2 0.0 1.4 1 0 0 1 1 1 0 Accessory recombination function protein Penicillinase_R PF03965.16 CAV18845.1 - 0.0035 17.7 0.0 0.0057 17.0 0.0 1.3 1 0 0 1 1 1 1 Penicillinase repressor HTH_Tnp_Tc3_2 PF01498.18 CAV18845.1 - 0.012 15.8 0.5 0.024 14.9 0.5 1.4 1 0 0 1 1 1 0 Transposase EF-hand_14 PF17959.1 CAV18845.1 - 0.097 13.0 0.0 0.18 12.2 0.0 1.4 1 0 0 1 1 1 0 EF-hand domain Inovirus_Gp2 PF11726.8 CAV18847.1 - 2.3e-70 236.2 0.9 2.7e-70 236.0 0.9 1.0 1 0 0 1 1 1 1 Inovirus Gp2 AlkA_N PF06029.11 CAV18849.1 - 0.12 12.7 0.0 0.12 12.6 0.0 1.2 1 0 0 1 1 1 0 AlkA N-terminal domain Inovirus_Gp2 PF11726.8 CAV18850.1 - 2.3e-14 53.7 0.1 3e-14 53.4 0.1 1.2 1 0 0 1 1 1 1 Inovirus Gp2 PRP8_domainIV PF12134.8 CAV18850.1 - 0.0099 15.6 0.1 0.011 15.4 0.1 1.1 1 0 0 1 1 1 1 PRP8 domain IV core TetR_C_19 PF17924.1 CAV18851.1 - 0.086 13.4 2.4 0.18 12.4 0.3 2.3 1 1 1 2 2 2 0 Tetracyclin repressor-like, C-terminal domain Phage_AlpA PF05930.12 CAV18853.1 - 1.9e-19 69.2 0.2 2.2e-19 69.0 0.2 1.1 1 0 0 1 1 1 1 Prophage CP4-57 regulatory protein (AlpA) HTH_17 PF12728.7 CAV18853.1 - 0.026 14.7 0.0 0.034 14.3 0.0 1.2 1 0 0 1 1 1 0 Helix-turn-helix domain Phage_integrase PF00589.22 CAV18854.1 - 3.2e-22 79.1 0.2 8.4e-22 77.8 0.0 1.7 2 0 0 2 2 2 1 Phage integrase family Arm-DNA-bind_3 PF13356.6 CAV18854.1 - 1.3e-19 70.4 0.2 2.6e-19 69.3 0.2 1.6 1 0 0 1 1 1 1 Arm DNA-binding domain Phage_int_SAM_3 PF14659.6 CAV18854.1 - 6.4e-11 42.4 0.2 1.4e-10 41.3 0.2 1.6 1 0 0 1 1 1 1 Phage integrase, N-terminal SAM-like domain DUF2726 PF10881.8 CAV18855.1 - 3e-39 133.8 0.0 4.3e-39 133.3 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2726) zf-C4_Topoisom PF01396.19 CAV18855.1 - 3.9e-05 23.3 2.6 7.8e-05 22.4 2.6 1.5 1 0 0 1 1 1 1 Topoisomerase DNA binding C4 zinc finger zf-GRF PF06839.12 CAV18855.1 - 0.0054 16.8 2.2 0.011 15.8 2.2 1.5 1 0 0 1 1 1 1 GRF zinc finger Ac76 PF05814.11 CAV18855.1 - 0.0064 16.5 0.2 0.012 15.7 0.2 1.4 1 0 0 1 1 1 1 Orf76 (Ac76) TMEMspv1-c74-12 PF11044.8 CAV18855.1 - 0.032 14.2 0.2 0.06 13.3 0.2 1.5 1 0 0 1 1 1 0 Plectrovirus spv1-c74 ORF 12 transmembrane protein Zn_ribbon_recom PF13408.6 CAV18855.1 - 0.25 11.9 1.9 0.68 10.5 1.9 1.7 1 0 0 1 1 1 0 Recombinase zinc beta ribbon domain GGDEF PF00990.21 CAV18857.1 - 2.8e-40 137.7 0.0 6.3e-40 136.6 0.0 1.6 1 0 0 1 1 1 1 Diguanylate cyclase, GGDEF domain TPR_12 PF13424.6 CAV18857.1 - 3.9e-11 43.1 2.3 0.001 19.3 0.0 3.8 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_MalT PF17874.1 CAV18857.1 - 9.6e-08 31.8 2.1 1.2e-06 28.2 1.9 2.4 1 1 1 2 2 2 1 MalT-like TPR region TPR_2 PF07719.17 CAV18857.1 - 2.4e-07 30.4 10.8 0.013 15.5 0.1 6.4 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_1 PF00515.28 CAV18857.1 - 0.00041 20.0 7.5 0.16 11.8 0.3 5.4 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_14 PF13428.6 CAV18857.1 - 0.0016 19.1 1.2 64 4.8 0.0 5.7 5 1 1 6 6 6 0 Tetratricopeptide repeat TPR_10 PF13374.6 CAV18857.1 - 0.0021 17.9 1.2 2.7 8.0 0.0 3.8 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_7 PF13176.6 CAV18857.1 - 0.02 14.9 1.0 0.97 9.6 0.0 3.8 3 0 0 3 3 3 0 Tetratricopeptide repeat GGDEF_2 PF17853.1 CAV18857.1 - 0.096 12.9 0.0 0.25 11.6 0.0 1.7 1 0 0 1 1 1 0 GGDEF-like domain Peptidase_M20 PF01546.28 CAV18858.1 - 9.1e-18 64.7 1.6 1.7e-17 63.8 1.6 1.5 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 CAV18858.1 - 1.4e-15 57.1 2.1 3.1e-14 52.8 0.5 2.4 2 0 0 2 2 2 1 Peptidase dimerisation domain Peptidase_M28 PF04389.17 CAV18858.1 - 1.6e-10 41.0 0.1 8e-09 35.5 0.0 2.3 2 1 0 2 2 2 1 Peptidase family M28 Peptidase_M42 PF05343.14 CAV18858.1 - 8.4e-09 34.8 2.2 0.00024 20.2 0.2 3.0 2 1 1 3 3 3 2 M42 glutamyl aminopeptidase DUF3859 PF12975.7 CAV18859.1 - 8.5e-47 158.5 0.3 9.9e-47 158.3 0.3 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF3859) AAA_33 PF13671.6 CAV18860.1 - 7.7e-12 45.6 0.1 1.7e-11 44.4 0.1 1.5 1 1 0 1 1 1 1 AAA domain KTI12 PF08433.10 CAV18860.1 - 0.00057 19.4 0.1 0.0036 16.8 0.0 1.8 1 1 1 2 2 2 1 Chromatin associated protein KTI12 AAA_18 PF13238.6 CAV18860.1 - 0.0049 17.4 0.0 0.0063 17.1 0.0 1.3 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 CAV18860.1 - 0.012 16.0 0.0 0.012 16.0 0.0 1.2 1 0 0 1 1 1 0 AAA ATPase domain AAA_22 PF13401.6 CAV18860.1 - 0.018 15.3 0.0 0.019 15.3 0.0 1.2 1 1 0 1 1 1 0 AAA domain AAA_24 PF13479.6 CAV18860.1 - 0.022 14.5 0.0 0.16 11.7 0.0 1.9 1 1 1 2 2 2 0 AAA domain Zeta_toxin PF06414.12 CAV18860.1 - 0.023 14.0 0.4 0.59 9.4 0.4 2.1 1 1 0 1 1 1 0 Zeta toxin GvpD PF07088.11 CAV18860.1 - 0.11 11.2 0.0 0.11 11.2 0.0 1.3 1 1 0 1 1 1 0 GvpD gas vesicle protein HTS PF04204.16 CAV18861.1 - 2.5e-134 446.9 0.0 2.9e-134 446.7 0.0 1.0 1 0 0 1 1 1 1 Homoserine O-succinyltransferase TPR_2 PF07719.17 CAV18862.1 - 7.1e-20 69.5 7.9 7.7e-05 22.5 0.1 4.4 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_1 PF00515.28 CAV18862.1 - 3.8e-17 61.3 8.1 0.00034 20.3 0.1 4.3 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_12 PF13424.6 CAV18862.1 - 5.6e-15 55.4 7.0 1.7e-09 37.8 0.4 3.3 1 1 0 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.6 CAV18862.1 - 4.8e-13 48.2 5.4 0.00038 20.4 0.2 4.6 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_19 PF14559.6 CAV18862.1 - 7.2e-13 48.8 1.8 0.00046 20.6 0.0 3.3 2 1 1 3 3 3 3 Tetratricopeptide repeat TPR_17 PF13431.6 CAV18862.1 - 2.2e-12 46.4 5.8 1.6e-06 28.0 0.2 4.4 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.6 CAV18862.1 - 1.5e-10 41.0 0.8 0.004 17.9 0.2 4.6 3 1 2 5 5 4 3 Tetratricopeptide repeat TPR_16 PF13432.6 CAV18862.1 - 3.4e-09 37.2 4.0 0.0017 19.0 0.2 2.6 2 1 0 2 2 2 2 Tetratricopeptide repeat TPR_6 PF13174.6 CAV18862.1 - 5e-09 36.2 8.8 0.026 15.2 0.1 4.8 4 1 1 5 5 4 3 Tetratricopeptide repeat TPR_7 PF13176.6 CAV18862.1 - 3.7e-08 32.8 5.1 0.064 13.3 0.3 4.4 2 1 2 4 4 4 2 Tetratricopeptide repeat TPR_10 PF13374.6 CAV18862.1 - 2.1e-05 24.2 7.5 0.026 14.4 0.0 3.7 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_11 PF13414.6 CAV18862.1 - 3.3e-05 23.5 7.8 0.0064 16.2 0.2 4.0 2 1 2 4 4 4 1 TPR repeat TPR_9 PF13371.6 CAV18862.1 - 0.00019 21.5 0.3 0.54 10.4 0.0 3.2 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_20 PF14561.6 CAV18862.1 - 0.00028 21.2 0.1 0.079 13.3 0.0 2.6 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_21 PF09976.9 CAV18862.1 - 0.00029 20.6 1.1 0.12 12.0 0.5 2.4 1 1 1 2 2 2 2 Tetratricopeptide repeat-like domain NARP1 PF12569.8 CAV18862.1 - 0.00035 19.6 1.0 0.0016 17.4 0.1 1.9 1 1 0 2 2 2 1 NMDA receptor-regulated protein 1 TPR_4 PF07721.14 CAV18862.1 - 0.0044 17.5 0.0 0.45 11.3 0.0 3.4 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_15 PF13429.6 CAV18862.1 - 0.0059 15.9 0.3 0.032 13.4 0.1 1.9 1 1 1 2 2 2 1 Tetratricopeptide repeat RPN7 PF10602.9 CAV18862.1 - 0.023 14.4 2.3 0.14 11.8 0.2 2.8 1 1 2 3 3 3 0 26S proteasome subunit RPN7 Fis1_TPR_C PF14853.6 CAV18862.1 - 0.028 14.5 3.3 31 4.8 0.1 4.2 3 1 1 4 4 4 0 Fis1 C-terminal tetratricopeptide repeat Sel1 PF08238.12 CAV18862.1 - 0.042 14.6 0.9 13 6.6 0.1 3.7 3 0 0 3 3 3 0 Sel1 repeat TPR_MalT PF17874.1 CAV18862.1 - 0.055 12.8 0.2 0.42 9.9 0.2 2.2 1 1 1 2 2 2 0 MalT-like TPR region ANAPC3 PF12895.7 CAV18862.1 - 0.085 13.1 4.7 1.3 9.3 2.6 2.8 1 1 2 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 Methyltransf_10 PF05971.12 CAV18863.1 - 1.1e-127 425.6 0.0 1.4e-127 425.1 0.0 1.1 1 0 0 1 1 1 1 RNA methyltransferase MTS PF05175.14 CAV18863.1 - 4.3e-06 26.4 0.0 8.1e-06 25.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain UPF0020 PF01170.18 CAV18863.1 - 0.048 13.3 0.0 0.088 12.5 0.0 1.4 1 0 0 1 1 1 0 Putative RNA methylase family UPF0020 Methyltransf_12 PF08242.12 CAV18863.1 - 0.13 13.0 0.1 0.47 11.2 0.0 2.1 2 0 0 2 2 2 0 Methyltransferase domain DUF45 PF01863.17 CAV18864.1 - 1e-10 42.1 0.8 1.1e-10 41.9 0.8 1.2 1 0 0 1 1 1 1 Protein of unknown function DUF45 WLM PF08325.10 CAV18864.1 - 2.8e-06 27.6 0.4 3.8e-06 27.1 0.4 1.2 1 0 0 1 1 1 1 WLM domain Borrelia_orfD PF02999.14 CAV18864.1 - 0.059 13.7 0.3 0.12 12.7 0.3 1.5 1 0 0 1 1 1 0 Borrelia orf-D family Glutaredoxin PF00462.24 CAV18865.1 - 4.7e-10 39.5 0.1 5.7e-10 39.3 0.1 1.1 1 0 0 1 1 1 1 Glutaredoxin Thioredoxin_4 PF13462.6 CAV18865.1 - 0.0019 18.4 0.3 0.16 12.1 0.2 2.0 1 1 1 2 2 2 2 Thioredoxin GST_N_3 PF13417.6 CAV18865.1 - 0.0035 17.7 0.0 0.0045 17.4 0.0 1.1 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain DUF836 PF05768.14 CAV18865.1 - 0.085 13.3 0.0 0.097 13.1 0.0 1.2 1 0 0 1 1 1 0 Glutaredoxin-like domain (DUF836) LysR_substrate PF03466.20 CAV18866.1 - 2.7e-43 147.8 0.0 4.1e-43 147.2 0.0 1.3 1 0 0 1 1 1 1 LysR substrate binding domain HTH_1 PF00126.27 CAV18866.1 - 7.1e-18 64.3 0.1 1.2e-17 63.6 0.1 1.3 1 0 0 1 1 1 1 Bacterial regulatory helix-turn-helix protein, lysR family DUF929 PF06053.11 CAV18866.1 - 0.09 12.1 0.0 0.14 11.4 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF929) P22_Cro PF14549.6 CAV18866.1 - 0.097 12.5 0.1 0.17 11.7 0.1 1.3 1 0 0 1 1 1 0 DNA-binding transcriptional regulator Cro HTH_30 PF13556.6 CAV18866.1 - 0.12 12.2 0.0 0.29 11.0 0.0 1.6 2 0 0 2 2 2 0 PucR C-terminal helix-turn-helix domain PBP_like_2 PF12849.7 CAV18866.1 - 0.2 11.3 0.0 0.34 10.5 0.0 1.3 1 0 0 1 1 1 0 PBP superfamily domain MFS_1 PF07690.16 CAV18867.1 - 6.9e-38 130.5 42.0 6.9e-38 130.5 42.0 1.8 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 CAV18867.1 - 3.7e-07 29.4 31.2 1.8e-06 27.1 6.1 4.0 2 2 2 4 4 4 2 Sugar (and other) transporter Folate_carrier PF01770.18 CAV18867.1 - 8.5e-07 28.0 3.4 1.4e-06 27.3 3.4 1.3 1 0 0 1 1 1 1 Reduced folate carrier OATP PF03137.20 CAV18867.1 - 0.0029 16.0 2.5 0.0029 16.0 2.5 2.4 2 1 0 2 2 2 1 Organic Anion Transporter Polypeptide (OATP) family Phage_holin_3_2 PF04550.12 CAV18867.1 - 2.7 8.6 7.7 1.3 9.6 3.1 2.7 2 0 0 2 2 2 0 Phage holin family 2 DUF1415 PF07209.12 CAV18868.1 - 1.3e-66 223.6 0.2 1.5e-66 223.4 0.2 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1415) PDDEXK_2 PF12784.7 CAV18868.1 - 0.012 15.2 0.3 0.018 14.6 0.3 1.2 1 0 0 1 1 1 0 PD-(D/E)XK nuclease family transposase GGDEF PF00990.21 CAV18869.1 - 6e-37 126.9 0.0 9.4e-37 126.2 0.0 1.3 1 0 0 1 1 1 1 Diguanylate cyclase, GGDEF domain GAF PF01590.26 CAV18869.1 - 9.3e-09 36.0 0.0 1.6e-08 35.3 0.0 1.3 1 0 0 1 1 1 1 GAF domain GAF_2 PF13185.6 CAV18869.1 - 2.6e-06 27.8 0.0 4.6e-06 27.0 0.0 1.3 1 0 0 1 1 1 1 GAF domain GAF_3 PF13492.6 CAV18869.1 - 0.014 15.7 0.0 0.025 14.9 0.0 1.3 1 0 0 1 1 1 0 GAF domain PRA-PH PF01503.17 CAV18870.1 - 1.9e-10 41.0 0.5 5.7e-09 36.3 0.5 2.4 2 0 0 2 2 2 1 Phosphoribosyl-ATP pyrophosphohydrolase Acetyltransf_1 PF00583.25 CAV18871.1 - 1.7e-15 57.3 0.0 2.5e-15 56.7 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_4 PF13420.7 CAV18871.1 - 1.9e-13 50.8 0.0 2.3e-13 50.6 0.0 1.0 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 CAV18871.1 - 1.8e-10 41.1 0.0 2.8e-10 40.5 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 CAV18871.1 - 1.9e-10 40.8 0.0 2.5e-10 40.4 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.7 CAV18871.1 - 4.6e-07 30.6 0.0 5.3e-07 30.4 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 CAV18871.1 - 0.0019 18.1 0.0 0.0041 17.0 0.0 1.6 1 1 0 1 1 1 1 FR47-like protein Acetyltransf_8 PF13523.6 CAV18871.1 - 0.011 15.4 0.0 0.035 13.8 0.0 1.9 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain YbgT_YccB PF08173.11 CAV18872.1 - 4.4e-13 49.1 3.5 5.7e-13 48.7 3.5 1.2 1 0 0 1 1 1 1 Membrane bound YbgT-like protein DUF4636 PF15468.6 CAV18872.1 - 0.013 15.3 0.3 0.013 15.2 0.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4636) Cyt_bd_oxida_II PF02322.15 CAV18873.1 - 1.4e-99 333.3 28.8 1.6e-99 333.1 28.8 1.0 1 0 0 1 1 1 1 Cytochrome bd terminal oxidase subunit II Cyt_bd_oxida_I PF01654.17 CAV18874.1 - 4.8e-175 582.2 20.4 5.5e-175 582.0 20.4 1.0 1 0 0 1 1 1 1 Cytochrome bd terminal oxidase subunit I HiaBD2 PF15403.6 CAV18874.1 - 0.16 12.4 0.1 0.35 11.3 0.1 1.5 1 0 0 1 1 1 0 HiaBD2_N domain of Trimeric autotransporter adhesin (GIN) Aminotran_1_2 PF00155.21 CAV18875.1 - 3.6e-27 95.5 0.0 5.5e-27 94.9 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II GntR PF00392.21 CAV18875.1 - 7.2e-10 38.4 0.0 2e-09 36.9 0.0 1.8 1 0 0 1 1 1 1 Bacterial regulatory proteins, gntR family Aminotran_MocR PF12897.7 CAV18875.1 - 0.0001 21.2 0.0 0.0002 20.3 0.0 1.4 1 0 0 1 1 1 1 Alanine-glyoxylate amino-transferase HTH_41 PF14502.6 CAV18875.1 - 0.002 17.8 0.0 0.0058 16.3 0.0 1.7 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_36 PF13730.6 CAV18875.1 - 0.03 14.3 0.0 0.09 12.8 0.0 1.8 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_24 PF13412.6 CAV18875.1 - 0.081 12.5 0.0 0.23 11.0 0.0 1.8 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding Aminotran_5 PF00266.19 CAV18875.1 - 0.093 11.7 0.0 0.14 11.1 0.0 1.2 1 0 0 1 1 1 0 Aminotransferase class-V LPMO_10 PF03067.15 CAV18876.1 - 4.3e-33 115.6 1.0 5e-33 115.4 0.2 1.6 2 0 0 2 2 2 1 Lytic polysaccharide mono-oxygenase, cellulose-degrading GbpA_2 PF18416.1 CAV18876.1 - 0.0016 18.7 0.2 0.0049 17.1 0.0 1.9 2 0 0 2 2 2 1 N-acetylglucosamine binding protein domain 2 PapD_C PF02753.17 CAV18876.1 - 0.026 14.9 0.6 3 8.3 0.1 2.6 2 0 0 2 2 2 0 Pili assembly chaperone PapD, C-terminal domain Trypan_PARP PF05887.11 CAV18876.1 - 0.046 13.7 1.2 0.58 10.1 0.1 2.2 2 0 0 2 2 2 0 Procyclic acidic repetitive protein (PARP) ABC_tran PF00005.27 CAV18879.1 - 3.1e-24 86.1 0.1 1.1e-23 84.3 0.0 1.8 2 0 0 2 2 2 1 ABC transporter AAA_21 PF13304.6 CAV18879.1 - 7.4e-10 39.1 1.5 5.3e-06 26.5 0.3 2.1 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 CAV18879.1 - 2.3e-08 33.7 0.2 1.5e-06 27.8 0.2 2.3 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 CAV18879.1 - 3.1e-06 26.8 0.2 1.4e-05 24.8 0.1 2.0 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_23 PF13476.6 CAV18879.1 - 2.1e-05 25.1 0.1 4.8e-05 24.0 0.1 1.5 1 1 0 1 1 1 1 AAA domain AAA_15 PF13175.6 CAV18879.1 - 0.00024 20.9 0.0 0.00037 20.3 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 CAV18879.1 - 0.00025 21.3 0.1 0.0034 17.6 0.1 2.2 1 1 0 1 1 1 1 AAA domain IstB_IS21 PF01695.17 CAV18879.1 - 0.00027 20.7 0.1 0.11 12.2 0.0 2.3 2 0 0 2 2 2 2 IstB-like ATP binding protein ABC_ATPase PF09818.9 CAV18879.1 - 0.00088 18.2 0.6 0.0055 15.6 0.3 2.0 2 0 0 2 2 2 1 Predicted ATPase of the ABC class RsgA_GTPase PF03193.16 CAV18879.1 - 0.0043 17.0 0.5 0.0095 15.9 0.2 1.7 2 0 0 2 2 2 1 RsgA GTPase AAA_27 PF13514.6 CAV18879.1 - 0.005 16.4 0.0 0.0095 15.5 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 CAV18879.1 - 0.012 15.3 0.1 0.22 11.2 0.1 2.1 2 0 0 2 2 2 0 AAA domain Dynamin_N PF00350.23 CAV18879.1 - 0.048 13.7 0.3 0.19 11.8 0.2 1.8 2 0 0 2 2 2 0 Dynamin family AAA_16 PF13191.6 CAV18879.1 - 0.05 14.0 0.4 0.1 12.9 0.3 1.9 1 1 0 1 1 1 0 AAA ATPase domain cobW PF02492.19 CAV18879.1 - 0.085 12.4 0.5 0.47 10.0 0.1 2.1 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_33 PF13671.6 CAV18879.1 - 0.096 12.8 0.2 0.28 11.3 0.1 1.8 2 0 0 2 2 2 0 AAA domain SbcCD_C PF13558.6 CAV18879.1 - 0.12 12.7 0.0 0.28 11.4 0.0 1.7 1 0 0 1 1 1 0 Putative exonuclease SbcCD, C subunit FecCD PF01032.18 CAV18880.1 - 3.3e-80 269.4 40.4 3.9e-80 269.2 40.4 1.0 1 0 0 1 1 1 1 FecCD transport family CoA_binding_3 PF13727.6 CAV18880.1 - 5.5 7.0 13.8 5.7 6.9 0.7 2.6 2 0 0 2 2 2 0 CoA-binding domain AstE_AspA PF04952.14 CAV18881.1 - 5.7e-67 225.8 0.7 7.1e-67 225.5 0.7 1.1 1 0 0 1 1 1 1 Succinylglutamate desuccinylase / Aspartoacylase family TRAM PF01938.20 CAV18881.1 - 0.13 12.2 0.0 0.25 11.4 0.0 1.4 1 0 0 1 1 1 0 TRAM domain Peptidase_M3 PF01432.20 CAV18882.1 - 3.3e-25 89.3 3.4 5.8e-25 88.5 3.4 1.4 1 1 0 1 1 1 1 Peptidase family M3 Peptidase_M3_N PF08439.10 CAV18882.1 - 2.6e-09 37.2 0.5 8.4e-09 35.6 0.0 2.1 2 0 0 2 2 2 1 Oligopeptidase F HsbA PF12296.8 CAV18882.1 - 0.13 12.7 0.2 0.51 10.8 0.3 2.0 2 0 0 2 2 2 0 Hydrophobic surface binding protein A His_Phos_1 PF00300.22 CAV18883.1 - 1.7e-34 119.3 0.0 2.1e-34 118.9 0.0 1.1 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) CobU PF02283.16 CAV18884.1 - 1.2e-56 191.0 0.1 1.4e-56 190.7 0.1 1.0 1 0 0 1 1 1 1 Cobinamide kinase / cobinamide phosphate guanyltransferase UvrD-helicase PF00580.21 CAV18884.1 - 0.018 14.6 0.0 0.022 14.3 0.0 1.2 1 0 0 1 1 1 0 UvrD/REP helicase N-terminal domain AAA_30 PF13604.6 CAV18884.1 - 0.048 13.4 0.3 0.33 10.6 0.3 1.9 1 1 0 1 1 1 0 AAA domain ZnuA PF01297.17 CAV18884.1 - 0.15 11.5 0.0 0.2 11.0 0.0 1.2 1 0 0 1 1 1 0 Zinc-uptake complex component A periplasmic CobS PF02654.15 CAV18885.1 - 1.4e-49 169.1 10.0 1.6e-49 168.9 10.0 1.0 1 0 0 1 1 1 1 Cobalamin-5-phosphate synthase DBI_PRT PF02277.17 CAV18886.1 - 1.4e-128 428.8 4.3 1.6e-128 428.6 4.3 1.0 1 0 0 1 1 1 1 Phosphoribosyltransferase Flavin_Reduct PF01613.18 CAV18887.1 - 5.4e-18 65.5 0.1 6.7e-18 65.2 0.1 1.1 1 0 0 1 1 1 1 Flavin reductase like domain Laminin_N PF00055.17 CAV18887.1 - 0.002 17.8 0.0 0.0032 17.1 0.0 1.3 1 0 0 1 1 1 1 Laminin N-terminal (Domain VI) DUF126 PF01989.16 CAV18887.1 - 0.049 13.4 0.0 0.15 11.9 0.0 1.8 2 0 0 2 2 2 0 Aconitase X swivel domain HIM1 PF08732.10 CAV18888.1 - 1.5e-10 40.9 0.0 2.2e-10 40.3 0.0 1.3 1 0 0 1 1 1 1 HIM1 Epimerase PF01370.21 CAV18888.1 - 2.6e-07 30.4 0.0 1e-06 28.4 0.0 1.8 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 CAV18888.1 - 3.2e-07 30.4 0.0 5e-07 29.8 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding Semialdhyde_dh PF01118.24 CAV18888.1 - 4e-06 27.3 0.0 7.1e-06 26.5 0.0 1.5 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain DapB_N PF01113.20 CAV18888.1 - 0.00042 20.4 0.0 0.0015 18.7 0.0 1.8 2 0 0 2 2 2 1 Dihydrodipicolinate reductase, N-terminus KR PF08659.10 CAV18888.1 - 0.0009 19.2 0.0 0.0018 18.2 0.0 1.5 2 0 0 2 2 2 1 KR domain NAD_binding_4 PF07993.12 CAV18888.1 - 0.001 18.3 0.0 0.0022 17.2 0.1 1.6 2 0 0 2 2 2 1 Male sterility protein Ldh_1_N PF00056.23 CAV18888.1 - 0.002 18.2 0.1 0.003 17.7 0.1 1.2 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain NmrA PF05368.13 CAV18888.1 - 0.093 12.3 0.0 0.15 11.6 0.0 1.5 1 1 0 1 1 1 0 NmrA-like family SDF PF00375.18 CAV18889.1 - 5.3e-99 331.9 43.8 6.7e-99 331.5 43.8 1.1 1 0 0 1 1 1 1 Sodium:dicarboxylate symporter family DUF2157 PF09925.9 CAV18889.1 - 6 6.7 15.9 7.6 6.3 8.5 3.6 2 1 0 2 2 2 0 Predicted membrane protein (DUF2157) DUF218 PF02698.17 CAV18890.1 - 4.7e-25 88.1 0.0 6e-25 87.8 0.0 1.1 1 0 0 1 1 1 1 DUF218 domain DUF2058 PF09831.9 CAV18891.1 - 2.3e-59 200.4 15.3 2.6e-59 200.3 15.3 1.0 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2058) Glycoprot_B_PH2 PF17417.2 CAV18891.1 - 0.034 14.5 0.7 0.055 13.8 0.7 1.4 1 0 0 1 1 1 0 Herpesvirus Glycoprotein B PH-like domain Big_8 PF17961.1 CAV18891.1 - 0.074 13.2 1.0 0.12 12.6 0.1 1.8 2 0 0 2 2 2 0 Bacterial Ig domain Gti1_Pac2 PF09729.9 CAV18891.1 - 0.91 9.6 6.4 1.3 9.1 6.4 1.3 1 0 0 1 1 1 0 Gti1/Pac2 family Bud13 PF09736.9 CAV18891.1 - 3.7 8.0 18.0 2.8 8.3 14.7 2.0 1 1 1 2 2 2 0 Pre-mRNA-splicing factor of RES complex Exo_endo_phos PF03372.23 CAV18892.1 - 5.9e-08 32.5 0.1 8.6e-08 32.0 0.1 1.4 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family bMG3 PF11974.8 CAV18892.1 - 0.033 14.2 0.2 4.3 7.4 0.1 2.4 2 0 0 2 2 2 0 Bacterial alpha-2-macroglobulin MG3 domain Carbpep_Y_N PF05388.11 CAV18893.1 - 0.12 13.0 4.0 2.6 8.6 0.0 3.4 3 1 1 4 4 4 0 Carboxypeptidase Y pro-peptide SpoIIIAH PF12685.7 CAV18893.1 - 0.74 9.6 10.6 19 5.0 10.6 2.2 1 1 0 1 1 1 0 SpoIIIAH-like protein Arabinose_bd PF12625.7 CAV18894.1 - 3.3e-31 108.8 0.0 4.6e-31 108.3 0.0 1.2 1 0 0 1 1 1 1 Arabinose-binding domain of AraC transcription regulator, N-term HTH_18 PF12833.7 CAV18894.1 - 5.7e-17 61.8 0.0 1.1e-16 60.9 0.0 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 CAV18894.1 - 4.6e-11 42.5 0.0 7.2e-07 29.2 0.0 2.9 3 0 0 3 3 3 2 Bacterial regulatory helix-turn-helix proteins, AraC family HTH_DeoR PF08220.12 CAV18894.1 - 0.00024 20.8 0.0 0.042 13.6 0.0 3.0 3 0 0 3 3 3 1 DeoR-like helix-turn-helix domain HTH_11 PF08279.12 CAV18894.1 - 0.004 17.1 0.0 0.037 14.0 0.0 2.4 2 0 0 2 2 2 1 HTH domain NUMOD1 PF07453.13 CAV18894.1 - 0.039 14.2 0.0 0.081 13.2 0.0 1.5 1 0 0 1 1 1 0 NUMOD1 domain GntR PF00392.21 CAV18894.1 - 0.11 12.2 0.0 0.43 10.3 0.0 2.0 2 0 0 2 2 2 0 Bacterial regulatory proteins, gntR family HTH_38 PF13936.6 CAV18894.1 - 0.11 12.3 0.0 20 5.1 0.0 2.6 2 0 0 2 2 2 0 Helix-turn-helix domain HTH_23 PF13384.6 CAV18894.1 - 0.12 12.2 0.0 0.85 9.5 0.0 2.2 2 0 0 2 2 2 0 Homeodomain-like domain HTH_36 PF13730.6 CAV18894.1 - 0.12 12.3 0.0 0.8 9.7 0.0 2.4 3 0 0 3 3 3 0 Helix-turn-helix domain DUF2804 PF10974.8 CAV18895.1 - 5e-91 305.6 0.5 5.7e-91 305.4 0.5 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2804) FA_hydroxylase PF04116.13 CAV18896.1 - 3.2e-32 111.6 13.3 3.2e-32 111.6 13.3 1.9 2 0 0 2 2 2 1 Fatty acid hydroxylase superfamily Exonuc_X-T_C PF08411.10 CAV18897.1 - 3.9e-105 350.8 2.5 4.9e-105 350.5 2.5 1.1 1 0 0 1 1 1 1 Exonuclease C-terminal RNase_T PF00929.24 CAV18897.1 - 2.3e-23 83.5 0.0 9.5e-23 81.5 0.0 2.0 2 0 0 2 2 2 1 Exonuclease LrgA PF03788.14 CAV18898.1 - 2.8e-16 59.2 9.5 3.1e-16 59.1 9.5 1.0 1 0 0 1 1 1 1 LrgA family LrgB PF04172.16 CAV18899.1 - 3.8e-73 245.5 16.4 4.3e-73 245.4 16.4 1.0 1 0 0 1 1 1 1 LrgB-like family dCMP_cyt_deam_2 PF08211.12 CAV18900.1 - 3.4e-43 147.0 0.9 2.3e-39 134.7 0.1 2.2 2 0 0 2 2 2 2 Cytidine and deoxycytidylate deaminase zinc-binding region dCMP_cyt_deam_1 PF00383.23 CAV18900.1 - 2.2e-12 46.8 0.0 4.7e-12 45.7 0.0 1.5 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region ATP-grasp PF02222.22 CAV18901.1 - 1.3e-56 190.9 0.0 1.9e-56 190.3 0.0 1.2 1 0 0 1 1 1 1 ATP-grasp domain CPSase_L_D2 PF02786.17 CAV18901.1 - 3.4e-06 26.7 0.0 5.9e-06 25.9 0.0 1.4 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Dala_Dala_lig_C PF07478.13 CAV18901.1 - 8.7e-06 25.4 0.0 4.5e-05 23.1 0.0 2.1 1 1 0 1 1 1 1 D-ala D-ala ligase C-terminus ATP-grasp_3 PF02655.14 CAV18901.1 - 6e-05 23.2 0.0 0.00014 22.0 0.0 1.6 1 1 0 1 1 1 1 ATP-grasp domain Epimerase PF01370.21 CAV18901.1 - 8.2e-05 22.2 0.0 0.00014 21.5 0.0 1.4 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 2-Hacid_dh_C PF02826.19 CAV18901.1 - 0.00098 18.5 0.0 0.0017 17.7 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain GARS_A PF01071.19 CAV18901.1 - 0.005 16.6 0.0 0.0096 15.7 0.0 1.5 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain DEAD_assoc PF08494.11 CAV18901.1 - 0.007 16.2 0.0 0.016 15.0 0.0 1.6 1 0 0 1 1 1 1 DEAD/H associated RmlD_sub_bind PF04321.17 CAV18901.1 - 0.033 13.3 0.0 0.05 12.7 0.0 1.3 1 0 0 1 1 1 0 RmlD substrate binding domain ATP-grasp_4 PF13535.6 CAV18901.1 - 0.039 13.5 0.1 0.16 11.6 0.1 2.0 1 1 0 1 1 1 0 ATP-grasp domain TPMT PF05724.11 CAV18902.1 - 3.3e-74 249.2 0.0 3.8e-74 249.0 0.0 1.0 1 0 0 1 1 1 1 Thiopurine S-methyltransferase (TPMT) Methyltransf_12 PF08242.12 CAV18902.1 - 0.003 18.3 0.0 0.0057 17.4 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CAV18902.1 - 0.0035 18.0 0.0 0.013 16.2 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CAV18902.1 - 0.0056 16.5 0.0 0.0073 16.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CAV18902.1 - 0.027 15.1 0.0 0.055 14.1 0.0 1.5 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_31 PF13847.6 CAV18902.1 - 0.19 11.5 0.0 0.44 10.3 0.0 1.7 1 1 0 1 1 1 0 Methyltransferase domain RelA_SpoT PF04607.17 CAV18904.1 - 0.00097 19.4 0.1 0.0023 18.2 0.1 1.6 1 1 0 1 1 1 1 Region found in RelA / SpoT proteins Bac_DNA_binding PF00216.21 CAV18905.1 - 7.3e-32 109.4 0.2 8.3e-32 109.3 0.2 1.0 1 0 0 1 1 1 1 Bacterial DNA-binding protein HU-HIG PF18291.1 CAV18905.1 - 5.5e-08 32.9 0.1 6.1e-08 32.8 0.1 1.1 1 0 0 1 1 1 1 HU domain fused to wHTH, Ig, or Glycine-rich motif HU-CCDC81_bac_2 PF18175.1 CAV18905.1 - 1.4e-06 28.1 0.1 2.6e-06 27.2 0.1 1.4 1 0 0 1 1 1 1 CCDC81-like prokaryotic HU domain 2 HU-DNA_bdg PF14848.6 CAV18905.1 - 0.00016 21.7 0.1 0.24 11.4 0.0 2.1 2 0 0 2 2 2 2 DNA-binding domain EamA PF00892.20 CAV18906.1 - 5.8e-25 88.1 45.3 1.6e-16 60.8 17.8 2.1 2 0 0 2 2 2 2 EamA-like transporter family Aminotran_1_2 PF00155.21 CAV18908.1 - 2.3e-34 119.2 0.0 8.2e-33 114.0 0.0 2.0 2 0 0 2 2 2 1 Aminotransferase class I and II GntR PF00392.21 CAV18908.1 - 5.8e-09 35.5 0.0 1.6e-08 34.1 0.0 1.8 1 0 0 1 1 1 1 Bacterial regulatory proteins, gntR family Cys_Met_Meta_PP PF01053.20 CAV18908.1 - 8.4e-05 21.3 0.0 0.00013 20.7 0.0 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme HTH_36 PF13730.6 CAV18908.1 - 0.013 15.5 0.0 0.04 13.9 0.0 1.9 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_IclR PF09339.10 CAV18908.1 - 0.023 14.5 0.0 0.085 12.7 0.0 2.0 2 0 0 2 2 2 0 IclR helix-turn-helix domain Rrf2 PF02082.20 CAV18908.1 - 0.053 13.9 0.0 0.2 12.1 0.0 1.9 1 0 0 1 1 1 0 Transcriptional regulator HTH_6 PF01418.17 CAV18908.1 - 0.13 12.2 0.0 0.39 10.7 0.0 1.7 1 0 0 1 1 1 0 Helix-turn-helix domain, rpiR family Aminotran_1_2 PF00155.21 CAV18909.1 - 1.9e-33 116.2 0.0 2.3e-33 115.9 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.21 CAV18909.1 - 1.5e-05 24.4 0.0 2.4e-05 23.8 0.0 1.4 1 0 0 1 1 1 1 Beta-eliminating lyase DegT_DnrJ_EryC1 PF01041.17 CAV18909.1 - 0.00022 20.7 0.5 0.0013 18.1 0.5 2.1 1 1 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_5 PF00266.19 CAV18909.1 - 0.0065 15.5 0.1 0.019 14.0 0.1 1.7 2 0 0 2 2 2 1 Aminotransferase class-V Cys_Met_Meta_PP PF01053.20 CAV18909.1 - 0.11 11.0 0.0 0.2 10.1 0.0 1.3 1 0 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme Response_reg PF00072.24 CAV18910.1 - 5.7e-26 90.9 1.0 5.7e-26 90.9 1.0 2.8 3 0 0 3 3 3 1 Response regulator receiver domain HATPase_c PF02518.26 CAV18910.1 - 2.7e-18 66.5 0.0 5.2e-18 65.6 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 CAV18910.1 - 3e-07 30.4 0.0 8.3e-07 29.0 0.0 1.7 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain HATPase_c_3 PF13589.6 CAV18910.1 - 0.0043 16.9 0.0 0.0092 15.8 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase FleQ PF06490.11 CAV18910.1 - 0.011 16.1 0.2 0.28 11.6 0.0 2.4 2 0 0 2 2 2 0 Flagellar regulatory protein FleQ HATPase_c_5 PF14501.6 CAV18910.1 - 0.083 12.8 0.0 0.26 11.2 0.0 1.8 1 0 0 1 1 1 0 GHKL domain ThrE PF06738.12 CAV18910.1 - 2.7 7.3 6.9 4.9 6.5 6.9 1.4 1 0 0 1 1 1 0 Putative threonine/serine exporter Peptidase_U4 PF03419.13 CAV18910.1 - 3.6 6.8 9.2 4.1 6.6 8.5 1.4 1 1 0 1 1 1 0 Sporulation factor SpoIIGA TauD PF02668.16 CAV18911.1 - 2.8e-59 201.1 0.3 3.1e-59 201.0 0.3 1.0 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family ACT_3 PF10000.9 CAV18912.1 - 6.3e-24 83.7 0.0 1.2e-23 82.8 0.0 1.5 1 0 0 1 1 1 1 ACT domain ACT_7 PF13840.6 CAV18912.1 - 8.3e-12 44.7 0.1 1.2e-11 44.2 0.1 1.2 1 0 0 1 1 1 1 ACT domain MCPsignal PF00015.21 CAV18913.1 - 6.6e-44 149.8 39.2 1.7e-39 135.4 21.7 2.4 1 1 1 2 2 2 2 Methyl-accepting chemotaxis protein (MCP) signalling domain dCache_1 PF02743.18 CAV18913.1 - 7.5e-21 75.0 0.8 7.5e-21 75.0 0.8 3.6 2 1 1 3 3 2 1 Cache domain HAMP PF00672.25 CAV18913.1 - 7.5e-15 55.0 0.5 1.9e-12 47.3 0.0 3.1 2 0 0 2 2 2 1 HAMP domain IFT57 PF10498.9 CAV18913.1 - 4.7e-05 22.5 4.8 4.7e-05 22.5 4.8 2.6 2 0 0 2 2 2 1 Intra-flagellar transport protein 57 DUF948 PF06103.11 CAV18913.1 - 0.012 15.8 32.8 32 4.9 2.8 5.6 1 1 1 3 3 3 0 Bacterial protein of unknown function (DUF948) NOG1 PF06858.14 CAV18913.1 - 0.057 13.2 0.1 0.17 11.7 0.1 1.8 1 0 0 1 1 1 0 Nucleolar GTP-binding protein 1 (NOG1) Pkip-1 PF06878.11 CAV18913.1 - 0.15 12.1 6.2 3.8 7.6 1.6 2.5 1 1 0 2 2 2 0 Pkip-1 protein dCache_2 PF08269.11 CAV18913.1 - 0.17 11.1 0.0 0.17 11.1 0.0 3.7 4 1 0 4 4 4 0 Cache domain Gp-FAR-1 PF05823.12 CAV18913.1 - 0.4 11.0 2.8 0.71 10.2 0.8 2.5 2 0 0 2 2 2 0 Nematode fatty acid retinoid binding protein (Gp-FAR-1) Prefoldin_2 PF01920.20 CAV18913.1 - 0.72 9.8 5.9 0.42 10.6 1.2 3.2 2 1 0 2 2 2 0 Prefoldin subunit AI-2E_transport PF01594.16 CAV18913.1 - 0.79 8.8 6.5 5.8 6.0 5.0 2.7 1 1 0 1 1 1 0 AI-2E family transporter CHDCT2 PF08074.11 CAV18913.1 - 1.8 8.7 10.1 2 8.6 2.8 2.8 2 0 0 2 2 2 0 CHDCT2 (NUC038) domain BLOC1_2 PF10046.9 CAV18913.1 - 2 8.8 18.5 2.3 8.6 0.5 4.6 2 2 2 4 4 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 HAP1_N PF04849.13 CAV18913.1 - 2.5 7.2 15.6 0.39 9.9 6.8 2.7 2 1 0 2 2 2 0 HAP1 N-terminal conserved region CREPT PF16566.5 CAV18913.1 - 8 6.6 15.1 1.6 8.9 0.4 3.7 3 2 1 4 4 4 0 Cell-cycle alteration and expression-elevated protein in tumour MIase PF02426.16 CAV18914.1 - 0.0013 18.9 0.1 0.014 15.5 0.0 2.3 2 1 0 2 2 2 1 Muconolactone delta-isomerase Cytochrom_C_2 PF01322.20 CAV18915.1 - 2.3e-22 80.1 0.0 3.1e-22 79.7 0.0 1.2 1 0 0 1 1 1 1 Cytochrome C' DUF1151 PF06625.11 CAV18916.1 - 0.031 14.2 2.8 0.036 14.0 2.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1151) Ni_hydr_CYTB PF01292.20 CAV18917.1 - 1.9e-20 73.3 8.2 1.9e-20 73.3 8.2 2.0 2 1 0 2 2 2 1 Prokaryotic cytochrome b561 DUF1826 PF08856.11 CAV18918.1 - 6.1e-68 228.7 0.0 7.2e-68 228.4 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1826) IspA PF04279.15 CAV18919.1 - 0.0034 17.6 4.4 0.0034 17.6 4.4 2.3 1 1 1 2 2 2 1 Intracellular septation protein A Bac_DNA_binding PF00216.21 CAV18920.1 - 1.6e-32 111.6 0.1 1.7e-32 111.5 0.1 1.0 1 0 0 1 1 1 1 Bacterial DNA-binding protein HU-CCDC81_bac_2 PF18175.1 CAV18920.1 - 2.5e-06 27.3 0.0 3.4e-06 26.8 0.0 1.2 1 0 0 1 1 1 1 CCDC81-like prokaryotic HU domain 2 HU-HIG PF18291.1 CAV18920.1 - 9.5e-06 25.7 0.0 1.1e-05 25.5 0.0 1.1 1 0 0 1 1 1 1 HU domain fused to wHTH, Ig, or Glycine-rich motif HU-CCDC81_euk_1 PF14908.6 CAV18920.1 - 0.011 15.9 0.0 0.012 15.8 0.0 1.1 1 0 0 1 1 1 0 CCDC81 eukaryotic HU domain 1 HU-CCDC81_euk_2 PF18289.1 CAV18920.1 - 0.048 13.8 0.0 0.072 13.3 0.0 1.3 1 0 0 1 1 1 0 CCDC81 eukaryotic HU domain 2 TraL PF07178.11 CAV18922.1 - 0.096 13.2 0.7 0.38 11.3 0.0 1.8 2 0 0 2 2 2 0 TraL protein PsbN PF02468.15 CAV18922.1 - 0.11 12.3 0.3 0.2 11.5 0.3 1.4 1 0 0 1 1 1 0 Photosystem II reaction centre N protein (psbN) 4HBT PF03061.22 CAV18923.1 - 3.9e-06 27.1 0.0 5.7e-06 26.6 0.0 1.2 1 0 0 1 1 1 1 Thioesterase superfamily 4HBT_3 PF13622.6 CAV18923.1 - 0.006 16.9 0.0 0.0079 16.5 0.0 1.1 1 0 0 1 1 1 1 Thioesterase-like superfamily End_tail_spike PF12219.8 CAV18923.1 - 0.082 13.0 0.0 0.12 12.5 0.0 1.3 1 0 0 1 1 1 0 Catalytic domain of bacteriophage endosialidase MaoC_dehydratas PF01575.19 CAV18923.1 - 0.12 12.0 0.0 0.18 11.4 0.0 1.3 1 0 0 1 1 1 0 MaoC like domain DUF134 PF02001.16 CAV18924.1 - 1.1e-19 70.8 0.0 1.2e-19 70.7 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function DUF134 HTH_23 PF13384.6 CAV18924.1 - 4e-07 29.7 0.1 6.3e-07 29.0 0.1 1.3 1 0 0 1 1 1 1 Homeodomain-like domain Sigma70_r4_2 PF08281.12 CAV18924.1 - 2.2e-06 27.3 0.5 2.9e-06 26.8 0.5 1.2 1 0 0 1 1 1 1 Sigma-70, region 4 HTH_29 PF13551.6 CAV18924.1 - 5.3e-05 23.2 0.1 8.2e-05 22.6 0.1 1.3 1 0 0 1 1 1 1 Winged helix-turn helix HTH_28 PF13518.6 CAV18924.1 - 0.00026 21.1 0.1 0.00059 19.9 0.1 1.6 1 1 0 1 1 1 1 Helix-turn-helix domain Sigma70_r4 PF04545.16 CAV18924.1 - 0.00035 20.0 1.0 0.00049 19.6 1.0 1.3 1 0 0 1 1 1 1 Sigma-70, region 4 HTH_3 PF01381.22 CAV18924.1 - 0.0048 16.9 0.6 0.008 16.2 0.4 1.5 2 0 0 2 2 2 1 Helix-turn-helix MarR_2 PF12802.7 CAV18924.1 - 0.01 15.7 0.2 0.015 15.2 0.2 1.3 1 0 0 1 1 1 0 MarR family HTH_10 PF04967.12 CAV18924.1 - 0.018 14.9 0.1 0.055 13.3 0.1 1.8 1 1 0 1 1 1 0 HTH DNA binding domain Sigma70_ECF PF07638.11 CAV18924.1 - 0.025 14.5 0.2 0.031 14.2 0.2 1.1 1 0 0 1 1 1 0 ECF sigma factor HTH_31 PF13560.6 CAV18924.1 - 0.026 14.9 0.6 0.032 14.6 0.6 1.3 1 1 0 1 1 1 0 Helix-turn-helix domain UPF0122 PF04297.14 CAV18924.1 - 0.089 13.0 0.0 0.14 12.4 0.0 1.4 1 1 0 1 1 1 0 Putative helix-turn-helix protein, YlxM / p13 like NqrM PF04400.13 CAV18925.1 - 1.2e-20 72.9 1.5 1.4e-20 72.7 1.5 1.1 1 0 0 1 1 1 1 (Na+)-NQR maturation NqrM Nitro_FeMo-Co PF02579.17 CAV18926.1 - 6.5e-11 42.4 0.3 1.1e-10 41.7 0.0 1.4 2 0 0 2 2 2 1 Dinitrogenase iron-molybdenum cofactor YcxB PF14317.6 CAV18927.1 - 1.1e-06 28.2 0.0 2e-06 27.4 0.0 1.4 1 0 0 1 1 1 1 YcxB-like protein Cys_Met_Meta_PP PF01053.20 CAV18928.1 - 6.6e-55 186.2 0.0 9.4e-55 185.7 0.0 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme AsnC_trans_reg PF01037.21 CAV18929.1 - 1.5e-22 79.4 0.0 2.3e-22 78.8 0.0 1.3 1 0 0 1 1 1 1 Lrp/AsnC ligand binding domain HTH_24 PF13412.6 CAV18929.1 - 2.7e-21 74.9 0.4 3.9e-21 74.3 0.4 1.3 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding HTH_AsnC-type PF13404.6 CAV18929.1 - 6e-18 64.4 0.9 8.6e-18 63.9 0.9 1.2 1 0 0 1 1 1 1 AsnC-type helix-turn-helix domain HTH_20 PF12840.7 CAV18929.1 - 3.6e-05 23.7 0.1 6.6e-05 22.9 0.1 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain MarR PF01047.22 CAV18929.1 - 0.00017 21.4 0.0 0.00031 20.6 0.0 1.3 1 0 0 1 1 1 1 MarR family HTH_Crp_2 PF13545.6 CAV18929.1 - 0.00021 21.2 0.0 0.00039 20.3 0.0 1.4 1 0 0 1 1 1 1 Crp-like helix-turn-helix domain MarR_2 PF12802.7 CAV18929.1 - 0.00051 19.9 0.1 0.00082 19.2 0.1 1.3 1 0 0 1 1 1 1 MarR family Rrf2 PF02082.20 CAV18929.1 - 0.008 16.5 0.1 0.055 13.8 0.0 2.0 2 0 0 2 2 2 1 Transcriptional regulator HTH_IclR PF09339.10 CAV18929.1 - 0.019 14.7 0.0 0.034 13.9 0.0 1.4 1 0 0 1 1 1 0 IclR helix-turn-helix domain DUF3427 PF11907.8 CAV18929.1 - 0.026 13.8 0.0 0.038 13.2 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3427) HTH_11 PF08279.12 CAV18929.1 - 0.029 14.3 0.0 0.053 13.5 0.0 1.4 1 0 0 1 1 1 0 HTH domain LexA_DNA_bind PF01726.16 CAV18929.1 - 0.082 12.7 0.0 0.19 11.5 0.0 1.6 1 0 0 1 1 1 0 LexA DNA binding domain HTH_CodY PF08222.11 CAV18929.1 - 0.14 11.7 0.0 0.3 10.6 0.0 1.6 1 0 0 1 1 1 0 CodY helix-turn-helix domain Sel1 PF08238.12 CAV18930.1 - 7.2e-30 102.8 20.2 9.1e-09 35.7 0.2 6.9 7 0 0 7 7 7 6 Sel1 repeat TPR_6 PF13174.6 CAV18930.1 - 0.00011 22.6 8.9 0.27 11.9 0.0 5.8 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_12 PF13424.6 CAV18930.1 - 0.0015 18.8 7.2 0.071 13.4 0.8 4.6 4 1 1 5 5 5 1 Tetratricopeptide repeat TPR_2 PF07719.17 CAV18930.1 - 0.0034 17.4 1.7 0.0034 17.4 1.7 7.0 9 0 0 9 9 9 1 Tetratricopeptide repeat TPR_11 PF13414.6 CAV18930.1 - 0.005 16.5 8.2 0.014 15.0 3.2 3.6 3 1 0 3 3 3 1 TPR repeat TPR_1 PF00515.28 CAV18930.1 - 0.017 14.9 17.6 0.24 11.3 1.7 6.4 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_20 PF14561.6 CAV18930.1 - 0.079 13.3 2.3 14 6.1 0.1 3.5 2 1 1 3 3 3 0 Tetratricopeptide repeat HPPK PF01288.20 CAV18932.1 - 2.8e-27 95.4 0.0 3.8e-27 95.0 0.0 1.2 1 0 0 1 1 1 1 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK) FolB PF02152.18 CAV18933.1 - 2.1e-26 92.7 0.0 2.3e-26 92.5 0.0 1.0 1 0 0 1 1 1 1 Dihydroneopterin aldolase Ebola_NP PF05505.12 CAV18933.1 - 0.089 11.1 0.0 0.11 10.8 0.0 1.1 1 0 0 1 1 1 0 Ebola nucleoprotein GTP_cyclohydroI PF01227.22 CAV18934.1 - 1.5e-60 203.7 0.1 1.8e-60 203.5 0.1 1.1 1 0 0 1 1 1 1 GTP cyclohydrolase I QueF PF14489.6 CAV18934.1 - 0.03 14.5 0.0 0.062 13.5 0.0 1.6 1 0 0 1 1 1 0 QueF-like protein adh_short_C2 PF13561.6 CAV18935.1 - 2e-25 89.8 0.0 2.2e-25 89.6 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CAV18935.1 - 6.1e-22 78.0 0.0 7e-22 77.8 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase Epimerase PF01370.21 CAV18935.1 - 2.2e-05 24.1 0.1 5.6e-05 22.7 0.1 1.8 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family KR PF08659.10 CAV18935.1 - 0.0012 18.8 0.2 0.0046 16.9 0.2 1.9 1 1 0 1 1 1 1 KR domain RmlD_sub_bind PF04321.17 CAV18935.1 - 0.057 12.5 0.0 0.087 11.9 0.0 1.3 1 0 0 1 1 1 0 RmlD substrate binding domain GDP_Man_Dehyd PF16363.5 CAV18935.1 - 0.14 11.6 0.6 0.31 10.4 0.1 1.9 2 1 1 3 3 3 0 GDP-mannose 4,6 dehydratase Peptidase_M1_N PF17900.1 CAV18936.1 - 0.028 14.6 0.2 0.033 14.4 0.2 1.1 1 0 0 1 1 1 0 Peptidase M1 N-terminal domain Patatin PF01734.22 CAV18937.1 - 2e-21 77.1 2.6 1.4e-20 74.4 2.6 2.1 1 1 0 1 1 1 1 Patatin-like phospholipase DUF3360 PF11840.8 CAV18939.1 - 7.9e-272 902.1 16.1 9.1e-272 901.9 16.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3360) DUF2834 PF11196.8 CAV18939.1 - 3.3 8.1 8.4 0.87 10.0 1.0 2.9 2 1 0 2 2 2 0 Protein of unknown function (DUF2834) Fun_ATP-synt_8 PF05933.13 CAV18939.1 - 8.9 6.6 8.0 2.5 8.4 1.2 3.0 3 0 0 3 3 3 0 Fungal ATP synthase protein 8 (A6L) T6SS_HCP PF05638.12 CAV18940.1 - 1.5e-25 90.0 0.0 2.7e-25 89.3 0.0 1.4 1 1 0 1 1 1 1 Type VI secretion system effector, Hcp DUF4225 PF13988.6 CAV18941.1 - 6.7e-24 84.3 6.3 4.6e-23 81.6 6.3 2.0 1 1 0 1 1 1 1 Protein of unknown function (DUF4225) DUF4118 PF13493.6 CAV18942.1 - 0.023 14.5 3.5 0.031 14.1 3.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4118) DUF3022 PF11226.8 CAV18943.1 - 0.037 14.5 0.0 0.078 13.4 0.0 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3022) PGAP1 PF07819.13 CAV18944.1 - 0.013 15.3 0.0 0.027 14.2 0.0 1.5 1 0 0 1 1 1 0 PGAP1-like protein LCAT PF02450.15 CAV18944.1 - 0.03 13.5 0.0 0.046 12.9 0.0 1.2 1 0 0 1 1 1 0 Lecithin:cholesterol acyltransferase GYF PF02213.16 CAV18944.1 - 0.11 12.2 0.1 0.27 10.9 0.1 1.6 1 0 0 1 1 1 0 GYF domain Abhydrolase_1 PF00561.20 CAV18945.1 - 6.9e-21 75.0 0.1 9e-20 71.4 0.1 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CAV18945.1 - 4.4e-20 73.2 0.0 5.3e-20 73.0 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CAV18945.1 - 4.4e-09 36.0 0.0 6.4e-09 35.4 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 PGAP1 PF07819.13 CAV18945.1 - 3.9e-05 23.5 0.3 0.00018 21.3 0.3 1.8 1 1 1 2 2 2 1 PGAP1-like protein Ndr PF03096.14 CAV18945.1 - 5e-05 22.1 0.0 0.00021 20.1 0.0 1.8 2 0 0 2 2 2 1 Ndr family DUF900 PF05990.12 CAV18945.1 - 0.0031 17.1 0.0 0.013 15.0 0.0 1.8 2 0 0 2 2 2 1 Alpha/beta hydrolase of unknown function (DUF900) Abhydrolase_5 PF12695.7 CAV18945.1 - 0.036 13.8 0.1 0.068 12.9 0.1 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase family Ser_hydrolase PF06821.13 CAV18945.1 - 0.051 13.4 0.0 0.079 12.8 0.0 1.4 1 0 0 1 1 1 0 Serine hydrolase Lipase PF00151.19 CAV18945.1 - 0.081 12.2 0.1 0.13 11.5 0.1 1.3 1 0 0 1 1 1 0 Lipase Palm_thioest PF02089.15 CAV18945.1 - 0.083 12.7 0.0 0.1 12.4 0.0 1.2 1 0 0 1 1 1 0 Palmitoyl protein thioesterase DisA_N PF02457.16 CAV18946.1 - 0.00064 19.3 0.1 0.0065 16.0 0.1 2.4 2 1 0 2 2 2 1 DisA bacterial checkpoint controller nucleotide-binding C-C_Bond_Lyase PF15617.6 CAV18946.1 - 0.096 11.8 0.1 0.81 8.8 0.0 1.9 1 1 1 2 2 2 0 C-C_Bond_Lyase of the TIM-Barrel fold S_2TMBeta PF18153.1 CAV18947.1 - 2.6e-19 69.7 6.6 3.1e-19 69.5 6.6 1.0 1 0 0 1 1 1 1 SMODS-associating 2TM, beta-strand rich effector domain B3_4 PF03483.17 CAV18949.1 - 6.6e-73 244.1 0.0 1.4e-72 243.0 0.0 1.6 1 0 0 1 1 1 1 B3/4 domain tRNA_synthFbeta PF17759.1 CAV18949.1 - 6.1e-58 195.8 0.0 9.2e-58 195.2 0.0 1.3 1 0 0 1 1 1 1 Phenylalanyl tRNA synthetase beta chain CLM domain FDX-ACB PF03147.14 CAV18949.1 - 1.7e-26 92.5 0.0 4e-26 91.2 0.0 1.7 1 0 0 1 1 1 1 Ferredoxin-fold anticodon binding domain tRNA_bind PF01588.20 CAV18949.1 - 3.4e-26 91.2 0.2 8e-26 90.0 0.2 1.7 1 0 0 1 1 1 1 Putative tRNA binding domain B5 PF03484.15 CAV18949.1 - 4.5e-21 74.9 0.0 2e-20 72.9 0.0 2.2 1 0 0 1 1 1 1 tRNA synthetase B5 domain PhetRS_B1 PF18262.1 CAV18949.1 - 2e-05 24.7 0.0 0.56 10.5 0.0 4.1 4 0 0 4 4 4 1 Phe-tRNA synthetase beta subunit B1 domain tRNA-synt_2d PF01409.20 CAV18950.1 - 6.2e-106 353.4 0.1 7.3e-106 353.1 0.1 1.1 1 0 0 1 1 1 1 tRNA synthetases class II core domain (F) Phe_tRNA-synt_N PF02912.18 CAV18950.1 - 4.8e-26 90.5 3.9 1e-25 89.4 3.9 1.5 1 0 0 1 1 1 1 Aminoacyl tRNA synthetase class II, N-terminal domain tRNA_synthFbeta PF17759.1 CAV18950.1 - 0.0018 17.7 0.0 0.0065 15.9 0.0 1.8 2 0 0 2 2 2 1 Phenylalanyl tRNA synthetase beta chain CLM domain LolA_like PF17131.4 CAV18952.1 - 2.9e-65 219.4 3.6 4.1e-65 219.0 3.6 1.2 1 0 0 1 1 1 1 Outer membrane lipoprotein-sorting protein DUF1329 PF07044.11 CAV18952.1 - 9.7e-15 54.7 3.2 5.6e-07 29.2 0.0 2.3 1 1 1 2 2 2 2 Protein of unknown function (DUF1329) MucB_RseB PF03888.14 CAV18952.1 - 0.0039 16.8 0.1 0.0065 16.0 0.1 1.4 1 0 0 1 1 1 1 MucB/RseB N-terminal domain DUF1571 PF07608.11 CAV18952.1 - 0.017 14.6 0.0 0.037 13.5 0.0 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1571) DUF4397 PF14344.6 CAV18952.1 - 0.074 13.8 0.4 0.72 10.6 0.1 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4397) MMPL PF03176.15 CAV18953.1 - 1.5e-37 129.3 22.3 2.9e-22 79.0 11.7 2.3 2 0 0 2 2 2 2 MMPL family Sterol-sensing PF12349.8 CAV18953.1 - 1.7e-11 44.2 20.1 3.2e-10 40.1 8.3 2.7 3 0 0 3 3 3 2 Sterol-sensing domain of SREBP cleavage-activation Patched PF02460.18 CAV18953.1 - 3.3e-05 22.2 32.6 0.00016 19.9 16.1 3.4 3 1 1 4 4 4 2 Patched family DUF4579 PF15158.6 CAV18953.1 - 0.42 10.3 0.0 0.42 10.3 0.0 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4579) DUF3149 PF11346.8 CAV18953.1 - 7.5 6.3 9.9 0.32 10.6 1.6 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF3149) TetR_N PF00440.23 CAV18954.1 - 1.7e-10 40.5 0.0 2.9e-10 39.8 0.0 1.4 1 0 0 1 1 1 1 Bacterial regulatory proteins, tetR family Mt_ATP-synt_B PF05405.14 CAV18956.1 - 0.12 11.9 1.3 2 8.0 1.0 2.2 2 0 0 2 2 2 0 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) HET-S PF17108.5 CAV18957.1 - 2.1 8.2 5.5 6.7 6.6 0.6 3.3 3 0 0 3 3 3 0 N-terminal small S protein of HET, non-prionic OMP_b-brl PF13505.6 CAV18958.1 - 6.9e-12 45.9 6.4 8.5e-12 45.5 6.4 1.1 1 0 0 1 1 1 1 Outer membrane protein beta-barrel domain OmpA_membrane PF01389.17 CAV18958.1 - 3.5e-09 36.7 0.6 4.8e-09 36.2 0.6 1.2 1 0 0 1 1 1 1 OmpA-like transmembrane domain Porin_4 PF13609.6 CAV18958.1 - 0.00082 19.2 1.7 0.00082 19.2 1.7 2.0 1 1 1 2 2 2 1 Gram-negative porin Porin_7 PF16956.5 CAV18958.1 - 0.094 12.4 2.3 0.17 11.5 2.3 1.8 1 1 0 1 1 1 0 Putative general bacterial porin DUF3418 PF11898.8 CAV18959.1 - 2.8e-230 766.0 0.6 4.7e-230 765.2 0.6 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3418) OB_NTP_bind PF07717.16 CAV18959.1 - 1e-23 83.5 0.0 2.1e-23 82.5 0.0 1.6 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold HA2 PF04408.23 CAV18959.1 - 6.6e-18 65.0 0.0 6.6e-18 65.0 0.0 2.3 2 0 0 2 2 1 1 Helicase associated domain (HA2) Helicase_C PF00271.31 CAV18959.1 - 1.2e-12 48.2 0.8 4.9e-12 46.2 0.0 2.6 3 1 0 3 3 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 CAV18959.1 - 5e-09 36.2 0.0 1.4e-08 34.7 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_19 PF13245.6 CAV18959.1 - 3.7e-06 27.3 0.1 2.9e-05 24.4 0.0 2.4 2 0 0 2 2 2 1 AAA domain T2SSE PF00437.20 CAV18959.1 - 0.00021 20.5 0.0 0.00063 18.9 0.0 1.8 1 0 0 1 1 1 1 Type II/IV secretion system protein ResIII PF04851.15 CAV18959.1 - 0.00073 19.6 0.0 0.0022 18.0 0.0 1.8 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 CAV18959.1 - 0.00079 19.7 0.5 0.0025 18.1 0.0 2.1 2 0 0 2 2 1 1 AAA domain AAA_30 PF13604.6 CAV18959.1 - 0.0013 18.5 0.0 0.0026 17.5 0.0 1.4 1 0 0 1 1 1 1 AAA domain NACHT PF05729.12 CAV18959.1 - 0.0024 17.8 0.0 0.0071 16.3 0.0 1.8 1 1 0 1 1 1 1 NACHT domain ABC_tran PF00005.27 CAV18959.1 - 0.0026 18.3 0.7 0.18 12.3 0.0 3.5 2 1 0 2 2 2 1 ABC transporter DUF2075 PF09848.9 CAV18959.1 - 0.0032 16.8 0.0 0.0086 15.3 0.0 1.7 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) Helicase_RecD PF05127.14 CAV18959.1 - 0.011 15.6 0.0 1.6 8.5 0.0 2.7 2 0 0 2 2 2 0 Helicase PhoH PF02562.16 CAV18959.1 - 0.033 13.6 0.0 0.079 12.4 0.0 1.6 1 0 0 1 1 1 0 PhoH-like protein AAA_25 PF13481.6 CAV18959.1 - 0.038 13.5 0.0 0.75 9.3 0.0 2.5 2 0 0 2 2 2 0 AAA domain RsgA_GTPase PF03193.16 CAV18959.1 - 0.068 13.1 0.0 0.17 11.8 0.0 1.6 1 0 0 1 1 1 0 RsgA GTPase TsaE PF02367.17 CAV18959.1 - 0.12 12.4 0.0 0.36 10.8 0.0 1.8 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE LYTB PF02401.18 CAV18959.1 - 0.12 11.6 0.0 0.23 10.7 0.0 1.4 1 0 0 1 1 1 0 LytB protein AAA_23 PF13476.6 CAV18959.1 - 0.46 10.9 8.4 1.1 9.7 0.0 3.7 3 0 0 3 3 3 0 AAA domain MipA PF06629.12 CAV18960.1 - 3.7e-26 92.7 9.1 7.2e-26 91.8 5.6 2.2 2 0 0 2 2 2 1 MltA-interacting protein MipA OMP_b-brl PF13505.6 CAV18960.1 - 0.0018 18.4 15.8 0.12 12.4 8.0 3.4 1 1 0 2 2 2 2 Outer membrane protein beta-barrel domain PhoD PF09423.10 CAV18962.1 - 1.3e-10 40.8 4.3 8.5e-08 31.6 2.4 3.4 2 1 0 2 2 2 2 PhoD-like phosphatase TerB PF05099.13 CAV18963.1 - 6.2e-39 133.2 0.1 7.4e-39 133.0 0.1 1.0 1 0 0 1 1 1 1 Tellurite resistance protein TerB DUF533 PF04391.12 CAV18963.1 - 2.4e-05 24.0 0.7 8.5e-05 22.2 0.7 1.6 1 1 0 1 1 1 1 Protein of unknown function (DUF533) HTH_Tnp_Tc5 PF03221.16 CAV18963.1 - 0.048 13.7 0.0 1.4 9.0 0.0 2.3 1 1 1 2 2 2 0 Tc5 transposase DNA-binding domain Trans_reg_C PF00486.28 CAV18965.1 - 1.4e-13 50.7 0.0 3e-13 49.7 0.0 1.5 1 0 0 1 1 1 1 Transcriptional regulatory protein, C terminal YCII PF03795.14 CAV18966.1 - 0.068 13.6 0.1 0.37 11.2 0.0 2.1 2 1 0 2 2 2 0 YCII-related domain ABM PF03992.16 CAV18967.1 - 3.5e-11 43.0 0.0 4.6e-11 42.7 0.0 1.1 1 0 0 1 1 1 1 Antibiotic biosynthesis monooxygenase RNase_T PF00929.24 CAV18968.1 - 4.1e-10 40.5 0.0 8e-10 39.5 0.0 1.5 1 1 0 1 1 1 1 Exonuclease GGDEF PF00990.21 CAV18969.1 - 1.8e-36 125.3 0.0 7.8e-36 123.3 0.0 2.0 2 0 0 2 2 2 1 Diguanylate cyclase, GGDEF domain CHASE PF03924.13 CAV18969.1 - 1.4e-26 93.6 0.0 2.2e-26 92.9 0.0 1.2 1 0 0 1 1 1 1 CHASE domain LapA_dom PF06305.11 CAV18969.1 - 0.044 13.6 0.4 3.4 7.6 0.0 2.7 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain ORF_12_N PF18042.1 CAV18969.1 - 0.17 12.3 0.0 3.8 8.0 0.1 2.4 2 0 0 2 2 2 0 ORF 12 gene product N-terminal DUF2760 PF10816.8 CAV18970.1 - 1.5e-53 179.9 0.4 3e-53 178.9 0.0 1.6 2 0 0 2 2 2 1 Domain of unknown function (DUF2760) Cas_St_Csn2 PF16813.5 CAV18970.1 - 0.027 13.6 1.1 0.037 13.2 1.1 1.1 1 0 0 1 1 1 0 CRISPR-associated protein Csn2 subfamily St PLAC9 PF15205.6 CAV18970.1 - 0.98 9.9 4.8 1.6 9.2 0.5 2.3 1 1 1 2 2 2 0 Placenta-specific protein 9 HSP70 PF00012.20 CAV18971.1 - 1.3e-16 60.0 0.0 1.3e-15 56.7 0.0 2.3 2 1 0 2 2 2 1 Hsp70 protein MreB_Mbl PF06723.13 CAV18971.1 - 3.9e-07 29.2 0.0 1.3e-06 27.5 0.0 1.8 2 0 0 2 2 2 1 MreB/Mbl protein MutL PF13941.6 CAV18971.1 - 0.0041 15.8 0.1 0.09 11.4 0.1 2.3 2 0 0 2 2 2 1 MutL protein FtsA PF14450.6 CAV18971.1 - 0.012 16.1 0.1 0.056 13.9 0.0 2.1 2 0 0 2 2 2 0 Cell division protein FtsA DUF3089 PF11288.8 CAV18971.1 - 0.035 13.7 0.2 0.083 12.4 0.1 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3089) SrfB PF07520.11 CAV18971.1 - 0.072 11.0 0.2 0.1 10.5 0.2 1.1 1 0 0 1 1 1 0 Virulence factor SrfB EutA PF06277.11 CAV18971.1 - 0.11 11.3 1.5 10 4.8 0.3 2.8 2 1 0 3 3 3 0 Ethanolamine utilisation protein EutA Ppx-GppA PF02541.16 CAV18971.1 - 0.15 11.5 0.3 0.36 10.2 0.3 1.6 1 0 0 1 1 1 0 Ppx/GppA phosphatase family DUF3731 PF12531.8 CAV18972.1 - 2.8e-49 168.2 1.9 6.3e-49 167.0 1.9 1.6 1 0 0 1 1 1 1 DNA-K related protein HSP70 PF00012.20 CAV18972.1 - 6.9e-18 64.2 0.3 7.8e-16 57.4 0.0 2.3 2 0 0 2 2 2 2 Hsp70 protein MreB_Mbl PF06723.13 CAV18972.1 - 3.2e-05 22.9 0.0 0.003 16.4 0.0 2.6 2 0 0 2 2 2 2 MreB/Mbl protein MRP-S27 PF10037.9 CAV18972.1 - 0.00095 18.1 1.2 0.002 17.1 1.2 1.4 1 0 0 1 1 1 1 Mitochondrial 28S ribosomal protein S27 BcrAD_BadFG PF01869.20 CAV18972.1 - 0.0048 16.4 0.0 0.14 11.6 0.0 2.4 2 0 0 2 2 2 1 BadF/BadG/BcrA/BcrD ATPase family TssO PF17561.2 CAV18972.1 - 0.16 12.1 0.0 0.31 11.1 0.0 1.4 1 0 0 1 1 1 0 Type VI secretion system, TssO DUF3731 PF12531.8 CAV18973.1 - 2.1e-48 165.3 0.2 2.3e-48 165.2 0.2 1.0 1 0 0 1 1 1 1 DNA-K related protein Phage_Cox PF10743.9 CAV18974.1 - 0.012 15.6 0.1 0.015 15.3 0.1 1.1 1 0 0 1 1 1 0 Regulatory phage protein cox G_glu_transpept PF01019.21 CAV18974.1 - 0.11 11.3 0.1 0.11 11.2 0.1 1.0 1 0 0 1 1 1 0 Gamma-glutamyltranspeptidase DUF2947 PF11163.8 CAV18975.1 - 6.9e-71 237.0 6.9 7.7e-71 236.9 6.9 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2947) Acetyltransf_3 PF13302.7 CAV18976.1 - 4.2e-19 69.6 0.0 5.2e-19 69.3 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 CAV18976.1 - 1.1e-08 35.3 0.0 1.4e-08 35.0 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 CAV18976.1 - 2.4e-05 24.5 0.0 3.5e-05 24.0 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_8 PF13523.6 CAV18976.1 - 0.036 13.7 0.0 0.064 12.9 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Sigma54_activat PF00158.26 CAV18977.1 - 1.4e-55 187.6 0.0 2.1e-55 187.0 0.0 1.3 1 0 0 1 1 1 1 Sigma-54 interaction domain Sigma54_activ_2 PF14532.6 CAV18977.1 - 7.2e-20 71.5 0.0 1.6e-19 70.4 0.0 1.6 1 0 0 1 1 1 1 Sigma-54 interaction domain HTH_50 PF18024.1 CAV18977.1 - 1.7e-18 65.9 0.1 4e-18 64.7 0.1 1.7 1 0 0 1 1 1 1 Helix-turn-helix domain PAS PF00989.25 CAV18977.1 - 9.1e-07 28.9 0.0 2.1e-06 27.7 0.0 1.6 1 0 0 1 1 1 1 PAS fold AAA_5 PF07728.14 CAV18977.1 - 6.7e-06 26.1 0.0 2e-05 24.6 0.0 1.9 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) PAS_8 PF13188.7 CAV18977.1 - 5.6e-05 23.1 0.0 0.00022 21.2 0.0 2.0 1 0 0 1 1 1 1 PAS domain PAS_4 PF08448.10 CAV18977.1 - 0.00041 20.6 0.0 0.00092 19.4 0.0 1.6 1 0 0 1 1 1 1 PAS fold AAA_3 PF07726.11 CAV18977.1 - 0.0008 19.3 0.0 0.0018 18.1 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA PF00004.29 CAV18977.1 - 0.00081 19.8 0.0 0.0024 18.3 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) ACT_4 PF13291.6 CAV18977.1 - 0.0016 19.0 0.1 0.013 16.1 0.1 2.4 2 1 0 2 2 1 1 ACT domain PAS_9 PF13426.7 CAV18977.1 - 0.0023 18.2 0.0 0.0086 16.3 0.0 2.0 2 0 0 2 2 2 1 PAS domain ACT PF01842.25 CAV18977.1 - 0.0073 16.1 0.1 0.016 15.0 0.1 1.6 1 0 0 1 1 1 1 ACT domain AAA_2 PF07724.14 CAV18977.1 - 0.013 15.6 0.0 0.026 14.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain (Cdc48 subfamily) NUMOD1 PF07453.13 CAV18977.1 - 0.013 15.7 0.1 0.027 14.7 0.1 1.5 1 0 0 1 1 1 0 NUMOD1 domain Mg_chelatase PF01078.21 CAV18977.1 - 0.021 14.2 0.1 7 6.0 0.0 2.5 3 0 0 3 3 3 0 Magnesium chelatase, subunit ChlI HTH_11 PF08279.12 CAV18977.1 - 0.024 14.6 0.1 0.058 13.3 0.1 1.7 1 0 0 1 1 1 0 HTH domain HTH_38 PF13936.6 CAV18977.1 - 0.027 14.2 0.0 0.06 13.1 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain AAA_7 PF12775.7 CAV18977.1 - 0.09 12.3 0.0 0.19 11.2 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region DUF815 PF05673.13 CAV18977.1 - 0.12 11.6 0.0 0.22 10.7 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF815) DUF697 PF05128.12 CAV18978.1 - 1.5e-50 171.1 2.3 1.5e-50 171.1 2.3 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF697) DUF463 PF04317.12 CAV18979.1 - 1.9e-183 610.4 0.1 2.2e-183 610.3 0.1 1.0 1 0 0 1 1 1 1 YcjX-like family, DUF463 MMR_HSR1 PF01926.23 CAV18979.1 - 0.04 14.0 0.0 1.6 8.8 0.1 2.6 2 0 0 2 2 2 0 50S ribosome-binding GTPase Arf PF00025.21 CAV18979.1 - 0.07 12.6 0.0 3.4 7.1 0.0 2.2 2 0 0 2 2 2 0 ADP-ribosylation factor family Tmemb_40 PF10160.9 CAV18980.1 - 0.023 14.2 1.0 0.026 14.0 1.0 1.0 1 0 0 1 1 1 0 Predicted membrane protein Fumerase PF05681.14 CAV18981.1 - 5.5e-99 331.0 0.4 5.5e-99 331.0 0.4 1.6 2 0 0 2 2 2 1 Fumarate hydratase (Fumerase) Fumerase_C PF05683.12 CAV18981.1 - 3.4e-84 281.3 0.2 5.9e-84 280.5 0.2 1.4 1 0 0 1 1 1 1 Fumarase C-terminus DUF4951 PF16309.5 CAV18981.1 - 0.023 14.7 1.0 0.76 9.9 0.0 3.4 3 1 0 3 3 3 0 Domian of unknown function (DUF4951) Chorismate_bind PF00425.18 CAV18982.1 - 6.5e-95 317.6 0.0 9.5e-95 317.0 0.0 1.2 1 0 0 1 1 1 1 chorismate binding enzyme Anth_synt_I_N PF04715.13 CAV18982.1 - 1.1e-26 93.8 0.0 3e-26 92.3 0.0 1.8 1 0 0 1 1 1 1 Anthranilate synthase component I, N terminal region N_NLPC_P60 PF12912.7 CAV18982.1 - 0.22 11.9 3.5 0.45 10.9 3.5 1.5 1 0 0 1 1 1 0 NLPC_P60 stabilising domain, N term OMP_b-brl PF13505.6 CAV18983.1 - 1.7e-24 86.9 5.5 2e-24 86.7 5.5 1.1 1 0 0 1 1 1 1 Outer membrane protein beta-barrel domain OmpA_membrane PF01389.17 CAV18983.1 - 5.4e-14 52.3 1.1 8e-14 51.8 1.1 1.2 1 0 0 1 1 1 1 OmpA-like transmembrane domain HATPase_c PF02518.26 CAV18984.1 - 1.2e-31 109.6 0.1 2.3e-31 108.6 0.1 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 CAV18984.1 - 4.9e-26 91.1 0.6 7e-25 87.4 0.2 2.6 2 0 0 2 2 2 1 Response regulator receiver domain HisKA PF00512.25 CAV18984.1 - 6.5e-17 61.3 0.2 6.5e-17 61.3 0.2 2.2 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain HATPase_c_3 PF13589.6 CAV18984.1 - 0.0011 18.8 0.0 0.0024 17.7 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_2 PF13581.6 CAV18984.1 - 0.012 15.5 0.1 0.032 14.2 0.0 1.8 2 0 0 2 2 2 0 Histidine kinase-like ATPase domain HNOB PF07700.15 CAV18985.1 - 2.1e-37 128.6 0.2 2.4e-37 128.4 0.2 1.0 1 0 0 1 1 1 1 Haem-NO-binding NUDIX PF00293.28 CAV18986.1 - 1.9e-11 44.2 0.0 2.4e-11 43.8 0.0 1.2 1 0 0 1 1 1 1 NUDIX domain Trp_Tyr_perm PF03222.13 CAV18987.1 - 5.9e-18 65.1 27.9 7.7e-18 64.7 27.9 1.0 1 0 0 1 1 1 1 Tryptophan/tyrosine permease family Aa_trans PF01490.18 CAV18987.1 - 7.2e-07 28.3 28.4 6.4e-06 25.1 28.4 2.2 1 1 0 1 1 1 1 Transmembrane amino acid transporter protein SDH_alpha PF03313.15 CAV18988.1 - 8.6e-97 323.9 6.1 1.1e-96 323.6 6.1 1.1 1 0 0 1 1 1 1 Serine dehydratase alpha chain SDH_beta PF03315.15 CAV18988.1 - 9.8e-54 181.9 0.1 2.2e-53 180.8 0.1 1.6 1 0 0 1 1 1 1 Serine dehydratase beta chain MmgE_PrpD PF03972.14 CAV18988.1 - 0.0011 17.6 0.8 0.0019 16.8 0.8 1.3 1 0 0 1 1 1 1 MmgE/PrpD family Trp_Tyr_perm PF03222.13 CAV18989.1 - 3.3e-76 256.9 32.3 3.8e-76 256.7 32.3 1.0 1 0 0 1 1 1 1 Tryptophan/tyrosine permease family Aa_trans PF01490.18 CAV18989.1 - 1.4e-11 43.7 21.5 1.4e-11 43.7 21.5 2.1 1 1 1 2 2 2 1 Transmembrane amino acid transporter protein Ceramidase PF05875.12 CAV18989.1 - 0.22 10.9 10.1 0.033 13.6 1.9 2.4 2 0 0 2 2 2 0 Ceramidase DUF3290 PF11694.8 CAV18989.1 - 0.64 10.0 4.0 2.4 8.1 0.1 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF3290) PTPS PF01242.19 CAV18990.1 - 3.4e-35 120.7 0.0 4e-35 120.5 0.0 1.1 1 0 0 1 1 1 1 6-pyruvoyl tetrahydropterin synthase MCPsignal PF00015.21 CAV18991.1 - 2.4e-41 141.4 23.6 2.4e-41 141.4 23.6 2.7 1 1 0 2 2 2 1 Methyl-accepting chemotaxis protein (MCP) signalling domain HAMP PF00672.25 CAV18991.1 - 8.1e-10 38.9 0.0 4.6e-09 36.5 0.0 2.4 1 0 0 1 1 1 1 HAMP domain Laminin_II PF06009.12 CAV18991.1 - 6.2e-05 23.0 35.1 0.0099 15.9 9.1 4.2 2 2 2 4 4 4 2 Laminin Domain II CheZ PF04344.13 CAV18991.1 - 0.00015 21.7 19.4 0.0073 16.2 7.4 2.9 2 1 0 2 2 2 2 Chemotaxis phosphatase, CheZ ERM PF00769.19 CAV18991.1 - 0.00056 19.8 20.0 0.015 15.2 6.1 2.3 2 0 0 2 2 2 2 Ezrin/radixin/moesin family DUF948 PF06103.11 CAV18991.1 - 0.094 13.0 36.8 0.71 10.2 0.8 6.3 3 2 3 6 6 6 0 Bacterial protein of unknown function (DUF948) DUF3754 PF12576.8 CAV18991.1 - 0.13 12.2 6.0 0.41 10.6 0.7 2.9 2 1 1 3 3 3 0 Protein of unknown function (DUF3754) Spc42p PF11544.8 CAV18991.1 - 0.31 11.1 7.8 0.08 12.9 0.5 3.2 3 0 0 3 3 3 0 Spindle pole body component Spc42p CENP-F_leu_zip PF10473.9 CAV18991.1 - 0.37 10.8 20.5 0.23 11.5 4.8 3.7 3 1 0 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Filament PF00038.21 CAV18991.1 - 0.43 10.1 21.2 0.97 8.9 7.1 2.4 2 0 0 2 2 2 0 Intermediate filament protein Laminin_I PF06008.14 CAV18991.1 - 0.61 9.7 40.3 0.69 9.6 12.1 4.0 3 2 1 4 4 4 0 Laminin Domain I DUF3130 PF11328.8 CAV18991.1 - 0.65 10.3 12.4 3.4 8.0 0.4 3.5 3 0 0 3 3 3 0 Protein of unknown function (DUF3130 FUSC PF04632.12 CAV18991.1 - 0.98 7.9 9.6 3.9 5.9 9.4 2.0 1 1 1 2 2 2 0 Fusaric acid resistance protein family FTR_C PF02741.15 CAV18991.1 - 1.2 9.1 9.9 0.092 12.8 1.5 2.9 2 1 1 3 3 3 0 FTR, proximal lobe DUF3450 PF11932.8 CAV18991.1 - 1.6 8.0 32.7 0.082 12.2 10.4 3.3 2 1 1 3 3 3 0 Protein of unknown function (DUF3450) Spc7 PF08317.11 CAV18991.1 - 1.7 7.4 30.4 2.7 6.8 10.2 2.5 1 1 0 2 2 2 0 Spc7 kinetochore protein Rx_N PF18052.1 CAV18991.1 - 1.8 8.9 7.5 23 5.4 1.6 4.4 1 1 2 3 3 3 0 Rx N-terminal domain Sec34 PF04136.15 CAV18991.1 - 2.3 8.1 32.1 6.7 6.6 4.9 5.4 2 2 2 5 5 5 0 Sec34-like family BLOC1_2 PF10046.9 CAV18991.1 - 2.6 8.4 24.5 0.24 11.7 0.4 4.4 2 2 3 5 5 5 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DASH_Duo1 PF08651.10 CAV18991.1 - 3.2 7.6 27.1 0.084 12.7 0.5 4.9 4 1 1 5 5 5 0 DASH complex subunit Duo1 DHR10 PF18595.1 CAV18991.1 - 3.9 7.5 28.5 0.034 14.2 4.5 4.2 3 1 1 4 4 3 0 Designed helical repeat protein 10 domain Med9 PF07544.13 CAV18991.1 - 5.2 7.2 13.8 4.8 7.3 0.3 3.8 2 2 1 4 4 4 0 RNA polymerase II transcription mediator complex subunit 9 NPV_P10 PF05531.12 CAV18991.1 - 6.3 7.3 30.9 11 6.6 5.9 5.4 2 2 1 3 3 2 0 Nucleopolyhedrovirus P10 protein TPR_MLP1_2 PF07926.12 CAV18991.1 - 6.3 6.9 31.9 1 9.4 11.7 2.9 2 1 0 2 2 2 0 TPR/MLP1/MLP2-like protein DUF4413 PF14372.6 CAV18991.1 - 8.3 6.8 6.2 7 7.1 0.4 3.2 4 0 0 4 4 3 0 Domain of unknown function (DUF4413) YabA PF06156.13 CAV18991.1 - 8.7 7.1 18.7 6.1 7.5 3.9 4.2 3 1 1 4 4 3 0 Initiation control protein YabA Sulfate_transp PF00916.20 CAV18992.1 - 4.6e-57 193.5 33.1 8.1e-54 182.8 31.7 2.5 1 1 0 1 1 1 1 Sulfate permease family MFS_MOT1 PF16983.5 CAV18992.1 - 1e-05 25.9 5.3 1e-05 25.9 5.3 3.6 4 0 0 4 4 4 1 Molybdate transporter of MFS superfamily STAS PF01740.21 CAV18992.1 - 0.00036 20.1 0.1 0.00073 19.2 0.1 1.4 1 0 0 1 1 1 1 STAS domain Peptidase_M50B PF13398.6 CAV18992.1 - 0.009 15.7 8.9 0.009 15.7 8.9 3.3 2 2 1 3 3 3 1 Peptidase M50B-like tRNA-synt_2 PF00152.20 CAV18993.1 - 2.9e-79 266.4 0.0 3.8e-79 266.0 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 CAV18993.1 - 1.5e-12 47.3 0.1 7.4e-12 45.1 0.0 2.3 2 0 0 2 2 2 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.20 CAV18993.1 - 0.018 14.5 0.2 3 7.3 0.0 2.4 2 0 0 2 2 2 0 tRNA synthetases class II core domain (F) tRNA_anti_2 PF13742.6 CAV18993.1 - 0.11 12.7 0.0 0.45 10.8 0.0 2.0 2 0 0 2 2 2 0 OB-fold nucleic acid binding domain Trypsin PF00089.26 CAV18995.1 - 2.5e-07 30.8 0.0 4.1e-07 30.0 0.0 1.4 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.6 CAV18995.1 - 5.4e-05 24.1 0.0 9.7e-05 23.3 0.0 1.4 1 0 0 1 1 1 1 Trypsin-like peptidase domain YfhO PF09586.10 CAV18995.1 - 0.075 11.3 0.0 0.1 10.8 0.0 1.1 1 0 0 1 1 1 0 Bacterial membrane protein YfhO DUF2970 PF11174.8 CAV18997.1 - 0.27 11.1 6.3 0.072 12.9 2.6 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2970) Holin_BlyA PF05102.12 CAV18997.1 - 0.43 10.6 4.4 0.12 12.4 1.5 1.5 2 0 0 2 2 2 0 holin, BlyA family DUF4179 PF13786.6 CAV18997.1 - 1.9 9.0 4.4 2.1 8.9 3.8 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4179) Aminotran_1_2 PF00155.21 CAV18998.1 - 4.3e-34 118.3 0.0 6.4e-33 114.4 0.0 2.0 2 0 0 2 2 2 1 Aminotransferase class I and II GntR PF00392.21 CAV18998.1 - 2.2e-13 49.6 0.0 5.7e-13 48.3 0.0 1.8 1 0 0 1 1 1 1 Bacterial regulatory proteins, gntR family Aminotran_MocR PF12897.7 CAV18998.1 - 1.8e-07 30.3 0.0 2.7e-07 29.7 0.0 1.2 1 0 0 1 1 1 1 Alanine-glyoxylate amino-transferase DegT_DnrJ_EryC1 PF01041.17 CAV18998.1 - 0.00012 21.5 0.0 0.00019 20.9 0.0 1.3 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Cys_Met_Meta_PP PF01053.20 CAV18998.1 - 0.0002 20.0 0.0 0.0003 19.5 0.0 1.1 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_5 PF00266.19 CAV18998.1 - 0.0041 16.1 0.0 0.0078 15.2 0.0 1.4 1 0 0 1 1 1 1 Aminotransferase class-V HTH_41 PF14502.6 CAV18998.1 - 0.12 12.0 0.0 0.25 11.1 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_28 PF13518.6 CAV18998.1 - 0.14 12.3 0.2 17 5.6 0.1 2.6 2 0 0 2 2 2 0 Helix-turn-helix domain HD_5 PF13487.6 CAV19000.1 - 1.8e-18 66.5 0.1 4.5e-18 65.3 0.1 1.7 1 0 0 1 1 1 1 HD domain HD PF01966.22 CAV19000.1 - 6.4e-17 61.9 0.0 1.1e-16 61.2 0.0 1.4 1 0 0 1 1 1 1 HD domain Big_9 PF17963.1 CAV19001.1 - 7.6e-12 45.8 0.8 8.6e-11 42.4 0.1 2.9 2 1 0 2 2 2 1 Bacterial Ig domain Cadherin_5 PF17892.1 CAV19001.1 - 5e-08 32.8 0.2 5e-08 32.8 0.2 2.5 3 0 0 3 3 3 1 Cadherin-like domain Laminin_G_3 PF13385.6 CAV19001.1 - 1.7e-06 28.2 0.3 1.7e-06 28.2 0.3 3.1 3 0 0 3 3 3 1 Concanavalin A-like lectin/glucanases superfamily Cadherin_4 PF17803.1 CAV19001.1 - 8e-05 23.2 2.1 0.00026 21.5 0.1 3.0 3 0 0 3 3 3 1 Bacterial cadherin-like domain F5_F8_type_C PF00754.25 CAV19001.1 - 0.0025 17.9 4.3 0.0067 16.5 0.3 2.8 2 0 0 2 2 2 1 F5/8 type C domain Laminin_G_1 PF00054.23 CAV19001.1 - 0.043 14.0 0.4 0.25 11.5 0.1 2.5 3 0 0 3 3 3 0 Laminin G domain Big_9 PF17963.1 CAV19002.1 - 1.1e-12 48.5 0.5 6e-12 46.1 0.5 2.3 1 0 0 1 1 1 1 Bacterial Ig domain Cadherin_5 PF17892.1 CAV19002.1 - 5.9e-07 29.4 0.3 1.6e-06 28.0 0.3 1.7 1 0 0 1 1 1 1 Cadherin-like domain Laminin_G_3 PF13385.6 CAV19002.1 - 1.9e-06 28.1 0.5 1.9e-06 28.1 0.5 3.1 3 0 0 3 3 3 2 Concanavalin A-like lectin/glucanases superfamily Cadherin_4 PF17803.1 CAV19002.1 - 0.00015 22.3 1.0 0.00074 20.1 0.3 2.5 2 0 0 2 2 2 1 Bacterial cadherin-like domain Laminin_G_2 PF02210.24 CAV19002.1 - 0.0027 18.3 1.4 0.027 15.0 0.1 2.9 2 1 0 2 2 2 1 Laminin G domain Laminin_G_1 PF00054.23 CAV19002.1 - 0.022 15.0 0.2 0.095 12.9 0.0 2.1 3 0 0 3 3 3 0 Laminin G domain Reprolysin_3 PF13582.6 CAV19002.1 - 0.14 12.7 1.4 0.58 10.7 1.4 2.1 1 1 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Aminotran_1_2 PF00155.21 CAV19003.1 - 1.6e-82 277.6 0.0 1.8e-82 277.4 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II RICTOR_N PF14664.6 CAV19003.1 - 0.083 11.9 0.0 0.14 11.1 0.0 1.2 1 0 0 1 1 1 0 Rapamycin-insensitive companion of mTOR, N-term OMP_b-brl PF13505.6 CAV19004.1 - 4.3e-09 36.8 5.5 1.7e-07 31.5 2.6 2.2 1 1 1 2 2 2 2 Outer membrane protein beta-barrel domain Porin_4 PF13609.6 CAV19004.1 - 1.2e-05 25.2 3.6 0.0031 17.3 0.1 2.2 1 1 0 2 2 2 2 Gram-negative porin TonB_dep_Rec PF00593.24 CAV19004.1 - 0.00027 20.9 3.7 0.0027 17.7 3.7 1.9 1 1 0 1 1 1 1 TonB dependent receptor DUF2490 PF10677.9 CAV19004.1 - 0.00093 19.2 0.1 0.54 10.2 0.1 2.2 2 0 0 2 2 2 2 Protein of unknown function (DUF2490) DUF294 PF03445.13 CAV19005.1 - 1.9e-46 157.3 0.0 3.3e-46 156.5 0.0 1.4 1 0 0 1 1 1 1 Putative nucleotidyltransferase DUF294 DUF294_C PF10335.9 CAV19005.1 - 1.2e-45 154.9 0.2 1.9e-45 154.2 0.2 1.3 1 0 0 1 1 1 1 Putative nucleotidyltransferase substrate binding domain CBS PF00571.28 CAV19005.1 - 3e-18 66.0 3.9 2.4e-10 40.7 0.2 2.9 2 0 0 2 2 2 2 CBS domain cNMP_binding PF00027.29 CAV19005.1 - 4.5e-15 55.5 0.0 1.1e-14 54.3 0.0 1.7 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain GlnD_UR_UTase PF08335.11 CAV19005.1 - 0.0023 18.1 0.0 0.0065 16.6 0.0 1.7 1 0 0 1 1 1 1 GlnD PII-uridylyltransferase RNase_T PF00929.24 CAV19006.1 - 4.6e-14 53.3 0.0 6.2e-14 52.9 0.0 1.2 1 0 0 1 1 1 1 Exonuclease DUF5051 PF16473.5 CAV19006.1 - 0.009 16.0 0.0 4.5 7.2 0.0 2.4 2 1 0 2 2 2 2 3' exoribonuclease, RNase T-like RNase_H_2 PF13482.6 CAV19006.1 - 0.043 13.8 0.0 0.075 13.0 0.0 1.4 1 0 0 1 1 1 0 RNase_H superfamily MOSC PF03473.17 CAV19007.1 - 4.6e-21 75.2 0.0 6.6e-21 74.7 0.0 1.2 1 0 0 1 1 1 1 MOSC domain 3-alpha PF03475.14 CAV19007.1 - 1e-10 41.3 0.0 2e-10 40.4 0.0 1.5 1 0 0 1 1 1 1 3-alpha domain Aminotran_5 PF00266.19 CAV19008.1 - 3e-60 204.1 0.0 3.5e-60 203.9 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-V DUF945 PF06097.11 CAV19009.1 - 1.4e-43 149.7 9.6 6.2e-43 147.6 9.6 1.9 1 1 0 1 1 1 1 Bacterial protein of unknown function (DUF945) HATPase_c PF02518.26 CAV19010.1 - 2.6e-20 73.0 0.3 5.6e-20 71.9 0.3 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase cNMP_binding PF00027.29 CAV19010.1 - 1.1e-15 57.4 0.0 2.5e-15 56.3 0.0 1.6 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain HisKA PF00512.25 CAV19010.1 - 1.1e-09 38.1 5.3 2.9e-08 33.6 0.1 3.6 4 0 0 4 4 4 2 His Kinase A (phospho-acceptor) domain HATPase_c_3 PF13589.6 CAV19010.1 - 6.8e-06 26.0 0.0 1.5e-05 24.8 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_5 PF14501.6 CAV19010.1 - 0.0002 21.2 0.2 0.00085 19.2 0.0 2.2 2 0 0 2 2 2 1 GHKL domain HD_5 PF13487.6 CAV19010.1 - 0.038 14.2 0.2 0.7 10.2 0.2 2.6 2 0 0 2 2 2 0 HD domain FlgN PF05130.12 CAV19010.1 - 2.8 8.4 12.3 1.1 9.8 8.7 2.2 2 0 0 2 2 2 0 FlgN protein Response_reg PF00072.24 CAV19011.1 - 2.7e-14 53.3 0.1 3.6e-14 52.9 0.1 1.2 1 0 0 1 1 1 1 Response regulator receiver domain Dioxygenase_N PF04444.14 CAV19011.1 - 0.1 12.5 0.1 0.77 9.7 0.0 2.1 2 0 0 2 2 2 0 Catechol dioxygenase N terminus PhageP22-tail PF09251.10 CAV19012.1 - 0.076 11.4 0.0 0.076 11.4 0.0 1.1 1 0 0 1 1 1 0 Salmonella phage P22 tail-spike TfoX_C PF04994.13 CAV19013.1 - 5.4e-28 96.9 0.0 8.5e-28 96.3 0.0 1.3 1 0 0 1 1 1 1 TfoX C-terminal domain TfoX_N PF04993.13 CAV19013.1 - 1e-22 80.2 0.0 1.5e-22 79.6 0.0 1.3 1 0 0 1 1 1 1 TfoX N-terminal domain HDOD PF08668.12 CAV19014.1 - 2.2e-34 118.7 0.1 3.2e-34 118.1 0.1 1.2 1 0 0 1 1 1 1 HDOD domain Lys_export PF03956.13 CAV19015.1 - 1.4e-53 181.2 29.4 2.1e-53 180.7 20.1 2.3 2 1 0 2 2 2 2 Lysine exporter LysO InaF-motif PF15018.6 CAV19015.1 - 4.2 7.3 9.0 4.4 7.3 0.1 3.8 3 0 0 3 3 3 0 TRP-interacting helix Peripla_BP_2 PF01497.18 CAV19016.1 - 0.043 13.4 0.1 0.061 12.9 0.1 1.2 1 0 0 1 1 1 0 Periplasmic binding protein Pyridoxal_deC PF00282.19 CAV19017.1 - 1.9e-56 191.4 0.0 2.6e-56 191.0 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Beta_elim_lyase PF01212.21 CAV19017.1 - 5.4e-10 39.0 0.0 8e-10 38.5 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase Aminotran_5 PF00266.19 CAV19017.1 - 2.4e-06 26.7 0.4 4.8e-06 25.8 0.4 1.6 1 1 0 1 1 1 1 Aminotransferase class-V SepSecS PF05889.13 CAV19017.1 - 0.00021 20.1 0.0 0.00033 19.5 0.0 1.2 1 0 0 1 1 1 1 O-phosphoseryl-tRNA(Sec) selenium transferase, SepSecS DUF5446 PF17522.2 CAV19017.1 - 0.017 15.3 0.5 0.061 13.5 0.0 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5446) DUF1319 PF07028.11 CAV19017.1 - 0.053 13.7 0.9 1.6 9.0 0.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1319) HTH_6 PF01418.17 CAV19018.1 - 1.4e-30 105.1 0.3 1.8e-29 101.5 0.1 2.3 2 0 0 2 2 2 1 Helix-turn-helix domain, rpiR family SIS PF01380.22 CAV19018.1 - 1.5e-24 86.3 0.2 2.3e-24 85.7 0.2 1.3 1 0 0 1 1 1 1 SIS domain SIS_2 PF13580.6 CAV19018.1 - 1.7e-08 34.5 1.2 3e-06 27.3 0.2 2.5 1 1 0 2 2 2 2 SIS domain HTH_Tnp_ISL3 PF13542.6 CAV19018.1 - 0.012 15.1 0.5 0.039 13.4 0.1 2.0 2 0 0 2 2 2 0 Helix-turn-helix domain of transposase family ISL3 HTH_29 PF13551.6 CAV19018.1 - 0.02 14.9 0.0 0.047 13.7 0.0 1.6 1 0 0 1 1 1 0 Winged helix-turn helix Penicillinase_R PF03965.16 CAV19018.1 - 0.056 13.8 0.0 0.11 12.9 0.0 1.5 1 0 0 1 1 1 0 Penicillinase repressor HTH_24 PF13412.6 CAV19018.1 - 0.062 12.9 0.0 0.17 11.5 0.0 1.8 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding MarR PF01047.22 CAV19018.1 - 0.098 12.6 0.0 0.4 10.6 0.0 2.0 2 0 0 2 2 2 0 MarR family DUF3640 PF12342.8 CAV19018.1 - 0.2 11.5 0.5 0.5 10.2 0.5 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3640) Fe-ADH PF00465.19 CAV19019.1 - 1.1e-87 294.2 0.3 1.4e-87 293.9 0.3 1.1 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase Fe-ADH_2 PF13685.6 CAV19019.1 - 4.7e-11 42.9 0.1 7e-06 25.9 0.0 2.2 2 0 0 2 2 2 2 Iron-containing alcohol dehydrogenase Glutaredoxin PF00462.24 CAV19020.1 - 1.3e-15 57.4 0.1 1.7e-15 57.0 0.1 1.1 1 0 0 1 1 1 1 Glutaredoxin DUF836 PF05768.14 CAV19020.1 - 0.00014 22.2 0.0 0.00016 22.0 0.0 1.2 1 0 0 1 1 1 1 Glutaredoxin-like domain (DUF836) Thioredoxin_2 PF13098.6 CAV19020.1 - 0.0045 17.4 0.1 0.0082 16.6 0.1 1.5 1 1 0 1 1 1 1 Thioredoxin-like domain zf-XS PF03470.14 CAV19020.1 - 0.012 15.9 0.6 0.16 12.3 0.6 2.2 1 1 0 1 1 1 0 XS zinc finger domain Thioredoxin_4 PF13462.6 CAV19020.1 - 0.05 13.8 0.2 0.3 11.2 0.1 1.8 1 1 1 2 2 2 0 Thioredoxin Asp-Al_Ex PF06826.12 CAV19021.1 - 1.2e-76 256.1 47.6 1.9e-41 141.6 21.2 2.1 2 0 0 2 2 2 2 Predicted Permease Membrane Region TrkA_C PF02080.21 CAV19021.1 - 1.7e-19 69.4 0.1 2.4e-08 33.7 0.0 2.5 2 0 0 2 2 2 2 TrkA-C domain Enoyl_reductase PF12241.8 CAV19022.1 - 1.7e-112 374.5 0.3 2.1e-112 374.2 0.3 1.1 1 0 0 1 1 1 1 Trans-2-enoyl-CoA reductase catalytic region Eno-Rase_NADH_b PF12242.8 CAV19022.1 - 3.2e-37 126.1 0.7 1e-36 124.5 0.7 1.9 2 0 0 2 2 2 1 NAD(P)H binding domain of trans-2-enoyl-CoA reductase Eno-Rase_FAD_bd PF07055.12 CAV19022.1 - 4.7e-30 103.8 1.3 8.6e-30 103.0 1.3 1.5 1 0 0 1 1 1 1 Enoyl reductase FAD binding domain adh_short_C2 PF13561.6 CAV19022.1 - 0.00043 19.9 0.2 0.89 9.1 0.1 2.3 1 1 1 2 2 2 2 Enoyl-(Acyl carrier protein) reductase Pro_sub2 PF18513.1 CAV19022.1 - 0.16 12.1 0.0 2.3 8.4 0.0 2.3 2 0 0 2 2 2 0 Prodomain subtilisin 2 DUF1974 PF09317.11 CAV19023.1 - 9.6e-112 373.2 0.9 1.2e-111 372.8 0.9 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1974) Acyl-CoA_dh_N PF02771.16 CAV19023.1 - 1.4e-13 51.5 0.0 3.7e-13 50.1 0.0 1.7 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.19 CAV19023.1 - 1.2e-10 41.4 0.0 2.4e-10 40.5 0.0 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_1 PF00441.24 CAV19023.1 - 1e-09 38.8 1.4 1.1e-09 38.6 0.2 1.7 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain TetR_C_30 PF17939.1 CAV19024.1 - 1.5e-29 102.5 0.0 8.7e-29 100.1 0.0 1.9 2 0 0 2 2 2 1 Tetracyclin repressor-like, C-terminal domain TetR_N PF00440.23 CAV19024.1 - 2.2e-12 46.6 0.0 5.1e-12 45.4 0.0 1.7 1 0 0 1 1 1 1 Bacterial regulatory proteins, tetR family Cadherin_4 PF17803.1 CAV19025.1 - 3.7e-18 65.9 116.6 1.1e-07 32.3 11.7 10.4 10 1 0 10 10 10 7 Bacterial cadherin-like domain Big_9 PF17963.1 CAV19025.1 - 1.7e-10 41.5 141.4 2.6e-05 24.9 17.3 11.9 5 2 5 10 10 10 6 Bacterial Ig domain Alpha-amylase_C PF02806.18 CAV19025.1 - 1e-06 29.1 14.5 1.1 9.8 0.2 6.9 6 0 0 6 6 6 4 Alpha amylase, C-terminal all-beta domain I-set PF07679.16 CAV19025.1 - 2.2e-06 27.6 13.6 1.3 9.2 0.2 5.3 5 0 0 5 5 5 4 Immunoglobulin I-set domain NHL PF01436.21 CAV19025.1 - 0.45 10.7 2.7 19 5.5 0.0 4.9 3 0 0 3 3 3 0 NHL repeat DNA_pol3_beta_3 PF02768.15 CAV19025.1 - 1.1 9.1 8.8 20 5.0 0.1 4.6 5 0 0 5 5 5 0 DNA polymerase III beta subunit, C-terminal domain OEP PF02321.18 CAV19026.1 - 3.6e-49 167.1 13.6 2.3e-27 96.0 7.4 2.0 2 0 0 2 2 2 2 Outer membrane efflux protein OmpA PF00691.20 CAV19027.1 - 9e-20 70.9 0.0 1.4e-19 70.3 0.0 1.3 1 0 0 1 1 1 1 OmpA family TSP_3 PF02412.18 CAV19027.1 - 0.00036 20.1 0.8 0.00036 20.1 0.8 2.0 2 0 0 2 2 2 1 Thrombospondin type 3 repeat Na_H_antiport_1 PF06965.12 CAV19028.1 - 5e-143 476.5 29.7 5.7e-143 476.3 29.7 1.0 1 0 0 1 1 1 1 Na+/H+ antiporter 1 CrtC PF07143.11 CAV19029.1 - 3.8e-45 154.5 3.0 5.8e-45 153.9 3.0 1.3 1 0 0 1 1 1 1 CrtC N-terminal lipocalin domain Lipocalin_9 PF17186.4 CAV19029.1 - 4.4e-33 114.3 0.8 7.3e-33 113.6 0.1 1.7 2 0 0 2 2 2 1 Lipocalin-like domain FtsX PF02687.21 CAV19030.1 - 1.1e-12 48.3 15.8 2.2e-08 34.4 4.9 5.2 6 0 0 6 6 6 2 FtsX-like permease family MacB_PCD PF12704.7 CAV19030.1 - 2.5e-09 37.8 0.0 5.6e-05 23.6 0.0 2.5 2 0 0 2 2 2 2 MacB-like periplasmic core domain ABC_tran PF00005.27 CAV19031.1 - 6.1e-31 107.8 0.0 7.9e-31 107.4 0.0 1.1 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 CAV19031.1 - 7.5e-06 26.0 0.8 0.028 14.2 0.0 2.1 1 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_16 PF13191.6 CAV19031.1 - 0.00017 22.0 0.2 0.00057 20.3 0.2 1.7 1 1 0 1 1 1 1 AAA ATPase domain AAA_25 PF13481.6 CAV19031.1 - 0.00021 21.0 0.0 0.25 10.9 0.0 2.2 2 0 0 2 2 2 2 AAA domain AAA_29 PF13555.6 CAV19031.1 - 0.00024 20.8 0.1 0.00041 20.0 0.1 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 CAV19031.1 - 0.00031 20.7 0.0 0.00051 20.0 0.0 1.3 1 0 0 1 1 1 1 RsgA GTPase TniB PF05621.11 CAV19031.1 - 0.00082 18.8 0.0 0.031 13.7 0.0 2.1 2 0 0 2 2 2 1 Bacterial TniB protein SMC_N PF02463.19 CAV19031.1 - 0.0012 18.4 0.0 0.17 11.3 0.0 2.1 2 0 0 2 2 2 1 RecF/RecN/SMC N terminal domain NACHT PF05729.12 CAV19031.1 - 0.0018 18.2 0.0 0.074 13.0 0.0 2.1 2 0 0 2 2 2 1 NACHT domain AAA_22 PF13401.6 CAV19031.1 - 0.0023 18.2 0.1 0.019 15.2 0.1 2.0 1 1 0 1 1 1 1 AAA domain MMR_HSR1 PF01926.23 CAV19031.1 - 0.019 15.0 0.0 0.038 14.1 0.0 1.5 1 0 0 1 1 1 0 50S ribosome-binding GTPase Dynamin_N PF00350.23 CAV19031.1 - 0.054 13.5 0.1 0.086 12.9 0.1 1.3 1 0 0 1 1 1 0 Dynamin family DLIC PF05783.11 CAV19031.1 - 0.078 11.8 0.0 0.11 11.4 0.0 1.1 1 0 0 1 1 1 0 Dynein light intermediate chain (DLIC) AAA_15 PF13175.6 CAV19031.1 - 0.17 11.6 0.0 11 5.5 0.0 2.1 2 0 0 2 2 2 0 AAA ATPase domain G-alpha PF00503.20 CAV19031.1 - 0.19 10.9 0.0 0.19 10.9 0.0 1.1 1 0 0 1 1 1 0 G-protein alpha subunit AAA_23 PF13476.6 CAV19031.1 - 0.2 12.1 0.0 0.36 11.3 0.0 1.3 1 0 0 1 1 1 0 AAA domain MatE PF01554.18 CAV19032.1 - 5.2e-45 153.0 40.5 1.9e-26 92.6 14.3 3.0 2 1 2 4 4 4 2 MatE Polysacc_synt_C PF14667.6 CAV19032.1 - 1.2e-05 25.4 13.1 1.2e-05 25.4 13.1 4.2 2 1 1 3 3 3 1 Polysaccharide biosynthesis C-terminal domain DUF4271 PF14093.6 CAV19032.1 - 4.8 7.0 17.6 0.62 9.9 5.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4271) DUF2867 PF11066.8 CAV19033.1 - 1.9e-14 54.2 0.0 3.1e-14 53.5 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2867) Epimerase PF01370.21 CAV19033.1 - 2.9e-10 40.0 0.0 4.8e-10 39.3 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 CAV19033.1 - 3.5e-09 36.8 0.0 5.5e-09 36.2 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding GDP_Man_Dehyd PF16363.5 CAV19033.1 - 5e-05 22.8 0.0 7.8e-05 22.2 0.0 1.2 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase NmrA PF05368.13 CAV19033.1 - 0.00037 20.1 0.0 0.00058 19.5 0.0 1.3 1 0 0 1 1 1 1 NmrA-like family RmlD_sub_bind PF04321.17 CAV19033.1 - 0.0057 15.8 0.0 0.012 14.8 0.0 1.5 2 0 0 2 2 2 1 RmlD substrate binding domain Semialdhyde_dh PF01118.24 CAV19033.1 - 0.0096 16.3 0.0 0.019 15.4 0.0 1.5 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain adh_short PF00106.25 CAV19033.1 - 0.23 10.9 0.0 0.41 10.1 0.0 1.4 1 0 0 1 1 1 0 short chain dehydrogenase DUF2913 PF11140.8 CAV19034.1 - 5.9e-80 267.9 0.0 6.7e-80 267.7 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2913) MFS_1 PF07690.16 CAV19035.1 - 1.7e-49 168.6 44.0 1.7e-49 168.6 44.0 1.7 1 1 1 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 CAV19035.1 - 5.4e-10 38.3 5.1 5.4e-10 38.3 5.1 1.8 2 1 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 CAV19035.1 - 6.8e-10 38.4 12.1 6.8e-10 38.4 12.1 3.2 1 1 1 2 2 2 1 Sugar (and other) transporter MFS_3 PF05977.13 CAV19035.1 - 1.7e-09 36.6 16.9 1.7e-09 36.6 16.9 2.0 2 0 0 2 2 2 1 Transmembrane secretion effector MFS_2 PF13347.6 CAV19035.1 - 4.2e-07 28.9 16.5 4.2e-07 28.9 16.5 2.9 1 1 2 3 3 3 2 MFS/sugar transport protein MFS_1_like PF12832.7 CAV19035.1 - 3.6e-06 26.1 28.7 1.2e-05 24.4 28.4 1.9 1 1 0 1 1 1 1 MFS_1 like family MFS_4 PF06779.14 CAV19035.1 - 1.4e-05 24.6 33.8 2.4e-05 23.8 33.8 1.3 1 0 0 1 1 1 1 Uncharacterised MFS-type transporter YbfB BT1 PF03092.16 CAV19035.1 - 0.00023 19.6 3.5 0.00023 19.6 3.5 2.3 2 0 0 2 2 2 1 BT1 family PsbT PF01405.17 CAV19035.1 - 1.5 8.7 6.5 0.52 10.2 1.4 3.0 2 0 0 2 2 2 0 Photosystem II reaction centre T protein UCR_UQCRX_QCR9 PF05365.12 CAV19035.1 - 3.8 7.5 5.8 0.9 9.5 1.0 2.5 2 0 0 2 2 2 0 Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like PseudoU_synth_2 PF00849.22 CAV19036.1 - 3.8e-18 66.1 0.0 1.3e-17 64.4 0.0 1.8 1 1 0 1 1 1 1 RNA pseudouridylate synthase S4 PF01479.25 CAV19036.1 - 2.1e-07 30.6 0.0 4.8e-07 29.4 0.0 1.6 2 0 0 2 2 2 1 S4 domain WaaY PF06176.11 CAV19036.1 - 0.031 13.9 0.0 0.044 13.4 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide core biosynthesis protein (WaaY) ResIII PF04851.15 CAV19037.1 - 2.4e-24 86.3 0.0 4.1e-24 85.5 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 CAV19037.1 - 1.5e-13 51.1 0.0 5.5e-13 49.2 0.0 2.0 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 CAV19037.1 - 4.7e-10 39.5 0.0 6.7e-09 35.8 0.0 2.3 2 0 0 2 2 2 1 DEAD/DEAH box helicase SWI2_SNF2 PF18766.1 CAV19037.1 - 9.7e-05 22.1 0.0 0.00017 21.3 0.0 1.4 1 0 0 1 1 1 1 SWI2/SNF2 ATPase AAA_22 PF13401.6 CAV19037.1 - 0.0038 17.5 0.1 0.012 15.8 0.1 1.8 1 1 0 1 1 1 1 AAA domain AAA_30 PF13604.6 CAV19037.1 - 0.0068 16.1 0.0 0.013 15.3 0.0 1.4 1 0 0 1 1 1 1 AAA domain DUF2075 PF09848.9 CAV19037.1 - 0.022 14.0 0.4 0.042 13.1 0.0 1.6 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) DZR PF12773.7 CAV19037.1 - 0.022 14.8 3.9 0.052 13.6 1.8 2.2 2 0 0 2 2 2 0 Double zinc ribbon AAA PF00004.29 CAV19037.1 - 0.024 15.1 0.1 0.16 12.4 0.0 2.3 3 0 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) SNF2_N PF00176.23 CAV19037.1 - 0.095 11.4 0.0 0.16 10.7 0.0 1.3 1 0 0 1 1 1 0 SNF2 family N-terminal domain zf-tcix PF14952.6 CAV19037.1 - 0.2 11.3 7.5 0.41 10.3 1.7 2.5 2 0 0 2 2 2 0 Putative treble-clef, zinc-finger, Zn-binding zf-ribbon_3 PF13248.6 CAV19037.1 - 0.83 9.2 7.0 2.6 7.6 1.3 2.5 2 0 0 2 2 2 0 zinc-ribbon domain zinc_ribbon_2 PF13240.6 CAV19037.1 - 2 8.2 8.6 1.5 8.6 2.0 2.5 2 0 0 2 2 2 0 zinc-ribbon domain EAL PF00563.20 CAV19038.1 - 4.9e-41 140.8 0.1 7.1e-41 140.3 0.1 1.2 1 0 0 1 1 1 1 EAL domain GGDEF PF00990.21 CAV19038.1 - 9.5e-16 58.0 0.0 2.1e-15 56.8 0.0 1.6 1 0 0 1 1 1 1 Diguanylate cyclase, GGDEF domain PepSY_2 PF13670.6 CAV19039.1 - 0.00022 21.1 0.5 0.27 11.3 0.1 2.4 2 1 0 2 2 2 2 Peptidase propeptide and YPEB domain Pcc1 PF09341.10 CAV19039.1 - 0.13 12.4 0.0 0.21 11.8 0.0 1.2 1 0 0 1 1 1 0 Transcription factor Pcc1 Response_reg PF00072.24 CAV19040.1 - 1.3e-23 83.3 0.0 2.1e-23 82.6 0.0 1.3 1 0 0 1 1 1 1 Response regulator receiver domain Trans_reg_C PF00486.28 CAV19040.1 - 5.7e-23 80.8 0.2 2.9e-22 78.5 0.1 2.1 2 0 0 2 2 2 1 Transcriptional regulatory protein, C terminal HATPase_c PF02518.26 CAV19041.1 - 2.3e-11 44.2 0.1 5.1e-11 43.1 0.1 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_2 PF13581.6 CAV19041.1 - 7.9e-05 22.6 0.1 0.00024 21.0 0.1 1.7 2 0 0 2 2 2 1 Histidine kinase-like ATPase domain Sds3 PF08598.11 CAV19041.1 - 0.00045 20.3 0.1 0.0014 18.7 0.1 1.8 1 1 0 1 1 1 1 Sds3-like HATPase_c_3 PF13589.6 CAV19041.1 - 0.0014 18.5 0.0 0.0025 17.6 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 CAV19041.1 - 0.0019 18.2 0.2 0.0063 16.5 0.2 2.0 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain Lectin_N PF03954.14 CAV19041.1 - 0.0022 17.7 0.5 0.0045 16.7 0.5 1.4 1 0 0 1 1 1 1 Hepatic lectin, N-terminal domain HATPase_c_5 PF14501.6 CAV19041.1 - 0.005 16.7 0.1 0.013 15.4 0.1 1.7 1 1 0 1 1 1 1 GHKL domain 7tm_7 PF08395.12 CAV19041.1 - 0.15 11.3 0.3 0.22 10.7 0.3 1.1 1 0 0 1 1 1 0 7tm Chemosensory receptor CopD PF05425.13 CAV19041.1 - 0.15 12.4 0.0 0.15 12.4 0.0 2.3 3 0 0 3 3 3 0 Copper resistance protein D LssY_C PF14067.6 CAV19042.1 - 4.3e-42 143.8 0.1 6e-42 143.3 0.1 1.1 1 0 0 1 1 1 1 LssY C-terminus SNARE_assoc PF09335.11 CAV19042.1 - 1.2e-14 54.8 7.5 1.2e-14 54.8 7.5 1.7 2 0 0 2 2 2 1 SNARE associated Golgi protein Herpes_LMP2 PF07415.11 CAV19042.1 - 0.053 12.3 1.1 0.083 11.7 1.1 1.2 1 0 0 1 1 1 0 Gammaherpesvirus latent membrane protein (LMP2) protein Wzy_C PF04932.15 CAV19042.1 - 0.11 12.1 0.0 0.11 12.1 0.0 2.4 2 1 0 2 2 2 0 O-Antigen ligase Glycos_transf_2 PF00535.26 CAV19043.1 - 3.1e-24 85.7 0.0 4.6e-24 85.1 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 CAV19043.1 - 6.8e-14 52.3 0.0 2.9e-13 50.3 0.0 1.7 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_2 PF10111.9 CAV19043.1 - 3.5e-11 43.1 0.1 5.6e-08 32.6 0.0 2.1 2 0 0 2 2 2 2 Glycosyltransferase like family 2 Glyco_transf_21 PF13506.6 CAV19043.1 - 1.8e-06 27.6 0.0 2.8e-06 26.9 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 21 Glyco_trans_2_3 PF13632.6 CAV19043.1 - 3.3e-05 23.9 0.0 6.9e-05 22.8 0.0 1.5 1 1 0 1 1 1 1 Glycosyl transferase family group 2 Glyco_transf_8 PF01501.20 CAV19043.1 - 0.0033 17.0 0.0 0.0048 16.5 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 8 Ribosomal_L25p PF01386.19 CAV19044.1 - 2.8e-22 79.0 0.1 3.1e-22 78.9 0.1 1.0 1 0 0 1 1 1 1 Ribosomal L25p family Herpes_UL42 PF02282.16 CAV19045.1 - 0.032 14.1 0.0 0.034 14.0 0.0 1.2 1 0 0 1 1 1 0 DNA polymerase processivity factor (UL42) NYN_YacP PF05991.11 CAV19045.1 - 0.05 13.5 0.1 1.7 8.5 0.0 2.2 1 1 1 2 2 2 0 YacP-like NYN domain ParD_like PF11903.8 CAV19047.1 - 3.2e-18 65.6 0.0 3.5e-18 65.4 0.0 1.0 1 0 0 1 1 1 1 ParD-like antitoxin of type II bacterial toxin-antitoxin system ParE-like_toxin PF15781.5 CAV19048.1 - 1.2e-36 124.5 0.5 1.3e-36 124.4 0.5 1.0 1 0 0 1 1 1 1 ParE-like toxin of type II bacterial toxin-antitoxin system YafQ_toxin PF15738.5 CAV19048.1 - 0.00023 21.4 1.4 0.0023 18.2 1.4 2.1 1 1 0 1 1 1 1 Bacterial toxin of type II toxin-antitoxin system, YafQ SurA_N_3 PF13624.6 CAV19049.1 - 0.027 14.3 0.2 0.038 13.8 0.2 1.1 1 0 0 1 1 1 0 SurA N-terminal domain SurA_N_2 PF13623.6 CAV19049.1 - 0.12 12.2 0.3 0.16 11.8 0.3 1.2 1 0 0 1 1 1 0 SurA N-terminal domain CMD PF02627.20 CAV19050.1 - 2.5e-10 40.3 0.0 2.8e-10 40.1 0.0 1.1 1 0 0 1 1 1 1 Carboxymuconolactone decarboxylase family DUF5137 PF17220.3 CAV19050.1 - 0.1 13.5 0.0 0.63 11.0 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF5137) FANC_SAP PF18081.1 CAV19050.1 - 0.15 12.2 0.0 2.1 8.5 0.0 2.0 2 0 0 2 2 2 0 Fanconi anemia-associated nuclease SAP domain Endotoxin_C2 PF18449.1 CAV19050.1 - 0.24 11.8 2.1 0.24 11.8 1.2 1.5 2 0 0 2 2 2 0 Delta endotoxin GFA PF04828.14 CAV19051.1 - 6.2e-16 58.5 1.1 8.1e-16 58.1 1.1 1.2 1 0 0 1 1 1 1 Glutathione-dependent formaldehyde-activating enzyme Transposase_20 PF02371.16 CAV19052.1 - 3.9e-21 75.2 0.1 8.6e-21 74.1 0.1 1.6 1 0 0 1 1 1 1 Transposase IS116/IS110/IS902 family DEDD_Tnp_IS110 PF01548.17 CAV19052.1 - 4.8e-14 52.5 0.2 1.5e-13 50.9 0.0 1.8 2 0 0 2 2 2 1 Transposase PI_PP_I PF18363.1 CAV19054.1 - 0.1 12.8 0.0 0.12 12.6 0.0 1.1 1 0 0 1 1 1 0 Phosphoinositide phosphatase insertion domain Gp49 PF05973.14 CAV19055.1 - 0.00023 21.2 0.0 0.00032 20.8 0.0 1.2 1 0 0 1 1 1 1 Phage derived protein Gp49-like (DUF891) rve PF00665.26 CAV19056.1 - 4.6e-32 110.7 0.0 9.6e-32 109.7 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain HTH_21 PF13276.6 CAV19056.1 - 2.5e-20 72.3 3.1 2.5e-20 72.3 3.1 2.2 3 0 0 3 3 3 1 HTH-like domain rve_3 PF13683.6 CAV19056.1 - 3e-17 62.2 0.2 8.7e-17 60.7 0.0 1.9 2 0 0 2 2 2 1 Integrase core domain DDE_Tnp_IS240 PF13610.6 CAV19056.1 - 4.9e-12 46.3 0.9 7.2e-12 45.7 0.1 1.7 2 0 0 2 2 2 1 DDE domain rve_2 PF13333.6 CAV19056.1 - 1.4e-10 41.2 0.6 2.9e-10 40.2 0.6 1.6 1 0 0 1 1 1 1 Integrase core domain DDE_3 PF13358.6 CAV19056.1 - 0.0048 16.7 0.0 0.0075 16.0 0.0 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc3_2 PF01498.18 CAV19056.1 - 0.01 16.0 1.1 0.025 14.8 1.1 1.7 1 0 0 1 1 1 0 Transposase HTH_17 PF12728.7 CAV19056.1 - 0.075 13.2 2.0 8.5 6.6 0.0 3.4 3 0 0 3 3 3 0 Helix-turn-helix domain UL21a PF17636.2 CAV19056.1 - 0.086 12.8 0.0 0.21 11.6 0.0 1.6 1 0 0 1 1 1 0 Viral Unique Long protein 21a Myb_DNA-bind_4 PF13837.6 CAV19056.1 - 0.11 12.9 0.5 0.47 10.9 0.2 2.1 2 0 0 2 2 2 0 Myb/SANT-like DNA-binding domain HTH_Tnp_1 PF01527.20 CAV19057.1 - 1e-14 54.6 1.2 1e-14 54.6 1.2 1.5 1 1 0 1 1 1 1 Transposase HTH_28 PF13518.6 CAV19057.1 - 0.00081 19.5 0.0 0.0015 18.6 0.0 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_23 PF13384.6 CAV19057.1 - 0.0019 17.9 0.0 0.0037 17.0 0.0 1.5 1 0 0 1 1 1 1 Homeodomain-like domain TSC22 PF01166.18 CAV19057.1 - 0.0033 17.7 0.9 0.0058 16.9 0.9 1.4 1 0 0 1 1 1 1 TSC-22/dip/bun family PDDEXK_9 PF08011.11 CAV19057.1 - 0.0075 16.2 2.5 0.72 9.8 1.1 2.1 2 0 0 2 2 2 2 PD-(D/E)XK nuclease superfamily Chibby PF14645.6 CAV19057.1 - 0.017 15.6 0.5 0.02 15.3 0.5 1.2 1 0 0 1 1 1 0 Chibby family HTH_29 PF13551.6 CAV19057.1 - 0.033 14.2 0.0 0.046 13.8 0.0 1.3 1 0 0 1 1 1 0 Winged helix-turn helix NUDIX PF00293.28 CAV19059.1 - 2.6e-14 53.4 0.0 3e-14 53.2 0.0 1.1 1 0 0 1 1 1 1 NUDIX domain NUDIX_4 PF14815.6 CAV19059.1 - 0.0099 15.8 0.0 0.013 15.5 0.0 1.2 1 0 0 1 1 1 1 NUDIX domain DUF615 PF04751.14 CAV19060.1 - 0.035 14.1 0.3 0.062 13.3 0.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF615) Transposase_20 PF02371.16 CAV19063.1 - 3.8e-21 75.2 0.1 8.4e-21 74.1 0.1 1.6 1 0 0 1 1 1 1 Transposase IS116/IS110/IS902 family DEDD_Tnp_IS110 PF01548.17 CAV19063.1 - 6.8e-15 55.3 0.2 2.1e-14 53.7 0.0 1.8 2 0 0 2 2 2 1 Transposase AbiGi PF10899.8 CAV19064.1 - 1.1e-55 188.3 0.6 1.3e-55 188.0 0.6 1.1 1 0 0 1 1 1 1 Putative abortive phage resistance protein AbiGi, antitoxin CPBP PF02517.16 CAV19066.1 - 0.0094 16.3 8.0 0.0094 16.3 8.0 1.8 1 1 1 2 2 2 1 CPBP intramembrane metalloprotease DHFR_1 PF00186.19 CAV19067.1 - 6.1e-37 126.8 0.0 7e-37 126.6 0.0 1.0 1 0 0 1 1 1 1 Dihydrofolate reductase DUF2207 PF09972.9 CAV19068.1 - 0.0018 17.1 0.1 0.0022 16.8 0.1 1.1 1 0 0 1 1 1 1 Predicted membrane protein (DUF2207) Ribosomal_L6e PF01159.19 CAV19068.1 - 0.075 13.6 3.0 0.1 13.1 0.7 2.3 2 1 0 2 2 2 0 Ribosomal protein L6e DUF3611 PF12263.8 CAV19068.1 - 0.098 12.5 1.0 5 7.0 0.0 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF3611) Barstar PF01337.18 CAV19069.1 - 5e-25 87.3 0.1 5.5e-25 87.2 0.1 1.0 1 0 0 1 1 1 1 Barstar (barnase inhibitor) HALZ PF02183.18 CAV19069.1 - 0.11 12.8 0.1 0.26 11.5 0.0 1.6 2 0 0 2 2 2 0 Homeobox associated leucine zipper PDDEXK_4 PF14281.6 CAV19070.1 - 5.1e-05 23.5 0.3 0.00011 22.4 0.3 1.6 1 0 0 1 1 1 1 PD-(D/E)XK nuclease superfamily DUF2120 PF09893.9 CAV19070.1 - 0.14 12.2 0.2 3.8 7.6 0.1 2.4 1 1 1 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2120) LPAM_1 PF08139.12 CAV19072.1 - 0.13 12.8 2.5 0.13 12.8 2.5 2.0 2 0 0 2 2 2 0 Prokaryotic membrane lipoprotein lipid attachment site DUF2381 PF09544.10 CAV19072.1 - 0.21 11.1 0.0 0.26 10.8 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2381) Phage_integrase PF00589.22 CAV19073.1 - 2.5e-38 131.5 0.4 4.3e-38 130.8 0.1 1.5 2 0 0 2 2 2 1 Phage integrase family Phage_int_SAM_4 PF13495.6 CAV19073.1 - 1.1e-22 80.3 2.8 2.2e-21 76.1 1.8 2.6 2 0 0 2 2 2 1 Phage integrase, N-terminal SAM-like domain Phage_int_SAM_1 PF02899.17 CAV19073.1 - 0.0011 19.2 3.3 0.0017 18.6 1.4 2.1 2 0 0 2 2 2 1 Phage integrase, N-terminal SAM-like domain Phage_integr_3 PF16795.5 CAV19073.1 - 0.011 15.6 0.0 3.3 7.6 0.0 2.7 3 0 0 3 3 3 0 Archaeal phage integrase p450 PF00067.22 CAV19074.1 - 1.1e-74 251.9 0.1 1.3e-74 251.7 0.1 1.0 1 0 0 1 1 1 1 Cytochrome P450 DUF3465 PF11948.8 CAV19076.1 - 4.8e-61 204.2 0.7 5.5e-61 204.0 0.7 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3465) DUF2805 PF10985.8 CAV19077.1 - 1.7e-35 121.2 0.0 1.9e-35 121.0 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2805) BLUF PF04940.12 CAV19079.1 - 3.7e-29 100.7 0.1 5.1e-29 100.3 0.1 1.2 1 0 0 1 1 1 1 Sensors of blue-light using FAD Ribonuc_red_sm PF00268.21 CAV19080.1 - 3.2e-90 302.4 0.7 3.7e-90 302.2 0.7 1.0 1 0 0 1 1 1 1 Ribonucleotide reductase, small chain Ribonuc_red_lgC PF02867.15 CAV19081.1 - 1.2e-137 459.7 0.0 8.5e-136 453.5 0.0 2.2 1 1 0 1 1 1 1 Ribonucleotide reductase, barrel domain RNR_N PF08343.10 CAV19081.1 - 3.5e-30 103.9 6.5 3.5e-30 103.9 6.5 2.2 2 0 0 2 2 2 1 Ribonucleotide reductase N-terminal Ribonuc_red_lgN PF00317.21 CAV19081.1 - 6.2e-11 42.2 0.1 1.9e-10 40.6 0.1 1.9 1 0 0 1 1 1 1 Ribonucleotide reductase, all-alpha domain Flavodoxin_NdrI PF07972.11 CAV19082.1 - 6.9e-45 152.1 0.0 7.8e-45 151.9 0.0 1.0 1 0 0 1 1 1 1 NrdI Flavodoxin like Glutaredoxin PF00462.24 CAV19083.1 - 9.5e-14 51.4 0.3 1.1e-13 51.2 0.3 1.1 1 0 0 1 1 1 1 Glutaredoxin DUF836 PF05768.14 CAV19083.1 - 0.0091 16.4 0.0 0.01 16.3 0.0 1.1 1 0 0 1 1 1 1 Glutaredoxin-like domain (DUF836) OTT_1508_deam PF14441.6 CAV19083.1 - 0.025 14.6 0.1 0.031 14.3 0.1 1.2 1 0 0 1 1 1 0 OTT_1508-like deaminase Transketolase_C PF02780.20 CAV19083.1 - 0.031 14.2 0.0 0.032 14.1 0.0 1.1 1 0 0 1 1 1 0 Transketolase, C-terminal domain GST_N PF02798.20 CAV19083.1 - 0.08 13.3 0.0 0.1 12.9 0.0 1.2 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain DUF501 PF04417.12 CAV19083.1 - 0.099 12.5 0.0 0.11 12.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF501) Tox-PL-2 PF15643.6 CAV19083.1 - 0.13 12.4 0.0 0.15 12.2 0.0 1.1 1 0 0 1 1 1 0 Papain fold toxin 2 Fe-S_biosyn PF01521.20 CAV19084.1 - 3.3e-17 62.7 0.0 3.7e-17 62.5 0.0 1.0 1 0 0 1 1 1 1 Iron-sulphur cluster biosynthesis UPF0051 PF01458.17 CAV19085.1 - 5.3e-66 222.4 0.2 7.1e-66 222.0 0.2 1.2 1 0 0 1 1 1 1 Uncharacterized protein family (UPF0051) ABC_tran PF00005.27 CAV19086.1 - 5.1e-21 75.6 0.0 7.3e-21 75.1 0.0 1.2 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 CAV19086.1 - 8.3e-08 31.9 0.4 0.0053 16.2 0.0 2.2 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 CAV19086.1 - 6.7e-06 26.1 0.0 0.025 14.4 0.0 2.2 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_33 PF13671.6 CAV19086.1 - 0.0002 21.5 0.0 0.00026 21.2 0.0 1.5 1 1 0 1 1 1 1 AAA domain AAA_29 PF13555.6 CAV19086.1 - 0.00056 19.6 0.1 0.0011 18.6 0.1 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 CAV19086.1 - 0.0011 18.9 0.1 0.0019 18.1 0.1 1.4 1 0 0 1 1 1 1 RsgA GTPase AAA_17 PF13207.6 CAV19086.1 - 0.0021 18.5 0.0 0.0044 17.5 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 CAV19086.1 - 0.0021 18.6 0.0 0.012 16.1 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_28 PF13521.6 CAV19086.1 - 0.0052 17.0 0.0 0.02 15.1 0.0 1.9 2 0 0 2 2 2 1 AAA domain Cytidylate_kin PF02224.18 CAV19086.1 - 0.011 15.5 0.0 0.015 15.1 0.0 1.3 1 0 0 1 1 1 0 Cytidylate kinase AAA_22 PF13401.6 CAV19086.1 - 0.013 15.8 0.3 0.12 12.7 0.3 2.2 1 1 0 1 1 1 0 AAA domain AAA_23 PF13476.6 CAV19086.1 - 0.021 15.3 0.4 0.045 14.3 0.1 1.7 2 0 0 2 2 2 0 AAA domain AAA_13 PF13166.6 CAV19086.1 - 0.027 13.1 0.0 0.038 12.6 0.0 1.2 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.6 CAV19086.1 - 0.047 13.3 0.0 0.11 12.1 0.0 1.6 2 0 0 2 2 2 0 AAA domain AAA_27 PF13514.6 CAV19086.1 - 0.075 12.6 0.1 0.13 11.8 0.1 1.3 1 0 0 1 1 1 0 AAA domain Ploopntkinase1 PF18748.1 CAV19086.1 - 0.11 12.0 0.1 0.31 10.5 0.0 1.7 2 0 0 2 2 2 0 P-loop Nucleotide Kinase1 UPF0051 PF01458.17 CAV19087.1 - 1.2e-61 208.2 6.0 1.6e-61 207.8 6.0 1.1 1 0 0 1 1 1 1 Uncharacterized protein family (UPF0051) Aminotran_5 PF00266.19 CAV19088.1 - 4.7e-145 483.2 0.1 5.3e-145 483.0 0.1 1.0 1 0 0 1 1 1 1 Aminotransferase class-V Aminotran_1_2 PF00155.21 CAV19088.1 - 1.1e-08 34.6 0.1 1.6e-08 34.2 0.1 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.20 CAV19088.1 - 1.1e-05 24.2 0.3 1.7e-05 23.5 0.3 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme DegT_DnrJ_EryC1 PF01041.17 CAV19088.1 - 3.9e-05 23.1 0.1 5.5e-05 22.6 0.1 1.1 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Beta_elim_lyase PF01212.21 CAV19088.1 - 0.0097 15.2 0.0 0.012 14.9 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase SufE PF02657.15 CAV19089.1 - 1.9e-39 134.3 0.1 2.2e-39 134.1 0.1 1.0 1 0 0 1 1 1 1 Fe-S metabolism associated domain MCPsignal PF00015.21 CAV19090.1 - 9.8e-39 132.9 44.7 2.3e-38 131.7 23.1 3.4 2 1 1 3 3 3 2 Methyl-accepting chemotaxis protein (MCP) signalling domain dCache_1 PF02743.18 CAV19090.1 - 2.1e-30 106.3 0.2 2.1e-30 106.3 0.2 3.8 2 1 1 3 3 3 1 Cache domain HAMP PF00672.25 CAV19090.1 - 2.6e-13 50.1 8.8 7.1e-11 42.3 0.1 4.1 4 0 0 4 4 4 2 HAMP domain GAPES1 PF17155.4 CAV19090.1 - 0.0013 18.1 1.7 0.0024 17.2 0.1 2.2 2 0 0 2 2 2 1 Gammaproteobacterial periplasmic sensor domain dCache_2 PF08269.11 CAV19090.1 - 0.05 12.8 7.7 0.12 11.6 0.0 3.6 3 1 0 3 3 3 0 Cache domain CREPT PF16566.5 CAV19090.1 - 0.076 13.2 10.6 0.072 13.3 1.6 2.7 2 1 0 2 2 2 0 Cell-cycle alteration and expression-elevated protein in tumour Filament PF00038.21 CAV19090.1 - 0.2 11.2 14.0 1.5 8.4 2.7 2.3 2 0 0 2 2 2 0 Intermediate filament protein DUF1161 PF06649.12 CAV19090.1 - 0.31 11.3 1.0 5 7.4 0.5 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1161) Methyltrn_RNA_2 PF04013.12 CAV19090.1 - 0.37 10.5 4.6 1.9 8.1 0.6 2.3 2 0 0 2 2 2 0 Putative SAM-dependent RNA methyltransferase Noelin-1 PF12308.8 CAV19090.1 - 0.38 10.8 7.2 0.2 11.7 0.2 3.5 3 2 1 4 4 4 0 Neurogenesis glycoprotein DUF948 PF06103.11 CAV19090.1 - 3.3 8.0 28.6 7.8 6.8 4.5 6.0 2 1 3 5 5 5 0 Bacterial protein of unknown function (DUF948) Fib_alpha PF08702.10 CAV19090.1 - 3.3 7.9 16.0 4.2 7.5 3.7 3.3 2 1 1 3 3 3 0 Fibrinogen alpha/beta chain family TMPIT PF07851.13 CAV19090.1 - 3.6 6.7 10.9 2.6 7.2 1.4 2.6 2 1 0 2 2 2 0 TMPIT-like protein IFT57 PF10498.9 CAV19090.1 - 3.8 6.4 14.6 0.56 9.1 3.6 2.3 2 0 0 2 2 2 0 Intra-flagellar transport protein 57 Tup_N PF08581.10 CAV19090.1 - 4 7.8 7.6 2 8.8 0.6 3.2 3 0 0 3 3 3 0 Tup N-terminal Laminin_II PF06009.12 CAV19090.1 - 5.6 7.0 25.4 1.5 8.8 4.9 3.7 2 2 1 3 3 3 0 Laminin Domain II TPR_MLP1_2 PF07926.12 CAV19090.1 - 6.7 6.8 25.9 1.2 9.2 6.3 2.8 2 1 0 2 2 2 0 TPR/MLP1/MLP2-like protein Katanin_con80 PF13925.6 CAV19090.1 - 8 6.5 8.4 12 6.0 0.6 3.6 3 1 0 3 3 3 0 con80 domain of Katanin BLOC1_2 PF10046.9 CAV19090.1 - 8.5 6.8 20.9 11 6.4 1.5 4.5 2 2 1 4 4 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 GARP PF16731.5 CAV19090.1 - 9.7 5.8 29.5 4.3 7.0 10.7 3.0 2 1 0 2 2 2 0 Glutamic acid/alanine-rich protein of Trypanosoma Spc7 PF08317.11 CAV19090.1 - 9.8 5.0 21.5 3.9 6.3 5.8 2.3 1 1 1 2 2 2 0 Spc7 kinetochore protein BCCT PF02028.17 CAV19091.1 - 4.6e-174 579.4 48.0 5.3e-174 579.2 48.0 1.0 1 0 0 1 1 1 1 BCCT, betaine/carnitine/choline family transporter BCCT PF02028.17 CAV19092.1 - 5.3e-172 572.6 44.4 6e-172 572.4 44.4 1.0 1 0 0 1 1 1 1 BCCT, betaine/carnitine/choline family transporter Response_reg PF00072.24 CAV19093.1 - 1.1e-28 99.6 2.8 1.7e-28 99.0 2.8 1.3 1 0 0 1 1 1 1 Response regulator receiver domain GerE PF00196.19 CAV19093.1 - 1.2e-22 79.2 2.5 1.4e-20 72.6 0.3 2.3 2 0 0 2 2 2 2 Bacterial regulatory proteins, luxR family Sigma70_r4_2 PF08281.12 CAV19093.1 - 4.3e-06 26.3 0.1 9.1e-06 25.3 0.1 1.5 1 0 0 1 1 1 1 Sigma-70, region 4 HTH_23 PF13384.6 CAV19093.1 - 0.00054 19.7 0.0 0.0012 18.6 0.0 1.6 1 0 0 1 1 1 1 Homeodomain-like domain HTH_28 PF13518.6 CAV19093.1 - 0.00068 19.7 0.0 0.0014 18.7 0.0 1.5 1 1 0 1 1 1 1 Helix-turn-helix domain HTH_29 PF13551.6 CAV19093.1 - 0.0045 17.0 0.0 0.0084 16.1 0.0 1.4 1 0 0 1 1 1 1 Winged helix-turn helix HTH_7 PF02796.15 CAV19093.1 - 0.0058 16.7 0.0 0.02 15.0 0.0 1.9 1 0 0 1 1 1 1 Helix-turn-helix domain of resolvase DUF2089 PF09862.9 CAV19093.1 - 0.03 14.3 0.2 0.11 12.5 0.1 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF2089) HTH_11 PF08279.12 CAV19093.1 - 0.046 13.7 0.2 0.092 12.7 0.2 1.6 1 0 0 1 1 1 0 HTH domain HTH_10 PF04967.12 CAV19093.1 - 0.056 13.2 0.1 0.13 12.1 0.1 1.7 1 0 0 1 1 1 0 HTH DNA binding domain Sigma70_ECF PF07638.11 CAV19093.1 - 0.061 13.2 0.1 0.15 12.0 0.0 1.6 2 0 0 2 2 2 0 ECF sigma factor Glyco_transf_25 PF01755.17 CAV19093.1 - 0.065 13.1 0.1 0.12 12.3 0.1 1.4 1 0 0 1 1 1 0 Glycosyltransferase family 25 (LPS biosynthesis protein) sCache_2 PF17200.4 CAV19094.1 - 2.2e-46 157.5 0.0 4e-46 156.7 0.0 1.4 1 0 0 1 1 1 1 Single Cache domain 2 dCache_2 PF08269.11 CAV19094.1 - 3.7e-38 131.4 0.1 3.7e-38 131.4 0.1 2.0 3 0 0 3 3 3 1 Cache domain Cache_3-Cache_2 PF17201.4 CAV19094.1 - 1.3e-13 51.0 0.5 3.4e-13 49.5 0.0 1.8 2 0 0 2 2 2 1 Cache 3/Cache 2 fusion domain HisKA_3 PF07730.13 CAV19094.1 - 1e-12 48.4 6.2 2.1e-12 47.3 3.2 2.9 3 0 0 3 3 3 1 Histidine kinase HATPase_c PF02518.26 CAV19094.1 - 5.9e-06 26.8 1.1 2.4e-05 24.8 1.1 2.0 1 1 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase dCache_1 PF02743.18 CAV19094.1 - 0.0013 18.6 0.1 0.0051 16.6 0.0 2.0 2 0 0 2 2 2 1 Cache domain TssO PF17561.2 CAV19094.1 - 0.03 14.4 1.0 0.42 10.7 0.1 2.4 2 0 0 2 2 2 0 Type VI secretion system, TssO Sensor_TM1 PF13755.6 CAV19094.1 - 0.065 13.0 0.8 1.1 9.0 0.0 2.5 2 0 0 2 2 2 0 Sensor N-terminal transmembrane domain DctM PF06808.12 CAV19095.1 - 3e-99 332.7 48.3 3.4e-99 332.5 48.3 1.0 1 0 0 1 1 1 1 Tripartite ATP-independent periplasmic transporter, DctM component CitMHS PF03600.16 CAV19095.1 - 1.2e-05 24.7 53.3 0.00012 21.4 21.4 2.4 1 1 1 2 2 2 2 Citrate transporter Bunya_G2 PF03563.13 CAV19095.1 - 7.7 5.7 5.7 20 4.3 5.7 1.6 1 0 0 1 1 1 0 Bunyavirus glycoprotein G2 DctQ PF04290.12 CAV19096.1 - 4.7e-26 91.3 2.3 4.7e-26 91.3 2.3 1.4 1 1 0 1 1 1 1 Tripartite ATP-independent periplasmic transporters, DctQ component DUF3021 PF11457.8 CAV19096.1 - 1.2 9.5 7.6 5.1 7.4 7.7 2.2 1 1 0 1 1 1 0 Protein of unknown function (DUF3021) DctP PF03480.13 CAV19097.1 - 1.5e-72 244.4 0.0 1.7e-72 244.2 0.0 1.1 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein, family 7 DUF5593 PF18007.1 CAV19098.1 - 0.099 13.4 2.5 0.14 12.9 2.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF5593) LTXXQ PF07813.12 CAV19098.1 - 0.48 11.2 5.5 0.86 10.4 5.5 1.5 1 0 0 1 1 1 0 LTXXQ motif family protein ASFV_J13L PF05568.11 CAV19098.1 - 0.82 9.4 5.7 0.6 9.8 4.4 1.4 1 1 0 1 1 1 0 African swine fever virus J13L protein DUF2982 PF11201.8 CAV19099.1 - 5.3e-50 168.9 0.5 8.9e-48 161.7 0.5 2.1 1 1 0 1 1 1 1 Protein of unknown function (DUF2982) Lactamase_B PF00753.27 CAV19100.1 - 7.9e-29 101.1 0.5 9.1e-29 100.9 0.5 1.0 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 CAV19100.1 - 3.2e-05 23.5 0.1 4.6e-05 23.0 0.1 1.2 1 0 0 1 1 1 1 Beta-lactamase superfamily domain GYD PF08734.11 CAV19100.1 - 0.039 13.9 0.0 0.067 13.2 0.0 1.3 1 0 0 1 1 1 0 GYD domain PDEase_II PF02112.15 CAV19100.1 - 0.096 11.8 0.0 0.12 11.4 0.0 1.1 1 0 0 1 1 1 0 cAMP phosphodiesterases class-II Peptidase_M15_2 PF05951.13 CAV19101.1 - 2.6e-67 225.3 0.0 3.1e-67 225.0 0.0 1.1 1 0 0 1 1 1 1 Bacterial protein of unknown function (DUF882) Peptidase_M15_3 PF08291.11 CAV19101.1 - 1.4e-14 54.1 0.0 1.9e-14 53.7 0.0 1.2 1 0 0 1 1 1 1 Peptidase M15 TAT_signal PF10518.9 CAV19101.1 - 0.004 16.9 0.2 0.007 16.2 0.2 1.5 1 0 0 1 1 1 1 TAT (twin-arginine translocation) pathway signal sequence DUF3267 PF11667.8 CAV19101.1 - 0.017 15.4 0.1 0.029 14.7 0.1 1.3 1 0 0 1 1 1 0 Putative zincin peptidase VanY PF02557.17 CAV19101.1 - 0.16 11.7 0.0 1.9 8.3 0.0 2.1 1 1 0 1 1 1 0 D-alanyl-D-alanine carboxypeptidase YkuD PF03734.14 CAV19102.1 - 1.2e-30 106.9 0.0 1.7e-30 106.3 0.0 1.3 1 0 0 1 1 1 1 L,D-transpeptidase catalytic domain PG_binding_1 PF01471.18 CAV19102.1 - 4.4e-08 33.2 0.0 1e-07 32.1 0.0 1.7 1 0 0 1 1 1 1 Putative peptidoglycan binding domain DUF1513 PF07433.11 CAV19103.1 - 1.4e-107 359.3 0.0 1.6e-107 359.1 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1513) TAT_signal PF10518.9 CAV19103.1 - 0.0016 18.2 1.1 0.0034 17.2 1.1 1.6 1 0 0 1 1 1 1 TAT (twin-arginine translocation) pathway signal sequence Peptidase_M75 PF09375.10 CAV19104.1 - 6.1e-35 121.1 11.8 7.7e-35 120.7 11.8 1.1 1 0 0 1 1 1 1 Imelysin DUF3458_C PF17432.2 CAV19104.1 - 0.0093 15.4 2.4 0.043 13.2 0.7 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF3458_C) ARM repeats TetR PF13972.6 CAV19104.1 - 0.11 12.2 2.2 0.66 9.7 0.4 2.4 2 0 0 2 2 2 0 Bacterial transcriptional repressor UPA_2 PF17809.1 CAV19104.1 - 0.18 11.6 0.0 0.52 10.1 0.0 1.7 2 0 0 2 2 2 0 UPA domain DHOR PF06537.11 CAV19105.1 - 1.8e-144 482.1 0.0 2.1e-144 481.8 0.0 1.0 1 0 0 1 1 1 1 Di-haem oxidoreductase, putative peroxidase Cytochrom_C PF00034.21 CAV19105.1 - 2.2e-10 41.5 0.0 1.3e-05 26.2 0.0 2.9 2 1 0 2 2 2 2 Cytochrome c Cytochrome_CBB3 PF13442.6 CAV19105.1 - 1.1e-05 25.6 0.1 0.31 11.4 0.1 3.2 2 1 0 2 2 2 2 Cytochrome C oxidase, cbb3-type, subunit III Cytochrome_C7 PF14522.6 CAV19105.1 - 0.037 14.0 0.1 3.8 7.6 0.0 2.5 2 0 0 2 2 2 0 Cytochrome c7 and related cytochrome c Cytochrom_C550 PF14495.6 CAV19105.1 - 0.085 12.6 0.1 2.5 7.8 0.0 2.4 2 0 0 2 2 2 0 Cytochrome c-550 domain FixO PF02433.15 CAV19105.1 - 0.11 11.9 0.0 1.7 8.0 0.0 2.5 3 0 0 3 3 3 0 Cytochrome C oxidase, mono-heme subunit/FixO Peptidase_M75 PF09375.10 CAV19106.1 - 4.5e-96 321.7 4.0 5.4e-96 321.4 4.0 1.0 1 0 0 1 1 1 1 Imelysin GTP_cyclohydro2 PF00925.20 CAV19107.1 - 3.8e-58 195.7 0.1 4.6e-58 195.4 0.1 1.1 1 0 0 1 1 1 1 GTP cyclohydrolase II DUF2027 PF09640.10 CAV19108.1 - 0.022 14.4 0.1 0.024 14.2 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF2027) BpuJI_N PF11564.8 CAV19108.1 - 0.043 13.0 0.5 0.048 12.9 0.5 1.0 1 0 0 1 1 1 0 Restriction endonuclease BpuJI - N terminal CcmH PF03918.14 CAV19109.1 - 7e-41 138.9 0.0 8.6e-41 138.6 0.0 1.1 1 0 0 1 1 1 1 Cytochrome C biogenesis protein Redoxin PF08534.10 CAV19110.1 - 1.8e-13 50.5 0.0 3.1e-13 49.7 0.0 1.4 1 1 0 1 1 1 1 Redoxin AhpC-TSA PF00578.21 CAV19110.1 - 1.8e-09 37.5 0.0 4.1e-09 36.4 0.0 1.6 1 1 0 1 1 1 1 AhpC/TSA family Thioredoxin PF00085.20 CAV19110.1 - 0.00016 21.6 0.2 0.003 17.5 0.1 2.4 2 1 0 2 2 2 1 Thioredoxin Thioredoxin_2 PF13098.6 CAV19110.1 - 0.00052 20.4 0.0 0.0012 19.3 0.0 1.6 1 0 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_8 PF13905.6 CAV19110.1 - 0.0018 18.6 0.0 0.0063 16.8 0.0 1.9 2 0 0 2 2 2 1 Thioredoxin-like CcmF_C PF16327.5 CAV19111.1 - 5e-65 219.9 15.8 5e-65 219.9 15.8 1.9 2 0 0 2 2 2 1 Cytochrome c-type biogenesis protein CcmF C-terminal Cytochrom_C_asm PF01578.20 CAV19111.1 - 3.6e-42 144.5 25.0 3.6e-42 144.5 25.0 4.9 4 1 2 6 6 6 1 Cytochrome C assembly protein ResB PF05140.14 CAV19111.1 - 0.44 9.2 4.3 1.5 7.5 0.1 2.7 2 1 1 3 3 3 0 ResB-like family zf-met2 PF12907.7 CAV19112.1 - 0.079 13.1 0.1 0.086 13.0 0.1 1.1 1 0 0 1 1 1 0 Zinc-binding NrfD PF03916.14 CAV19113.1 - 1.2e-78 265.0 34.5 1.3e-78 264.8 34.5 1.0 1 0 0 1 1 1 1 Polysulphide reductase, NrfD Fer4_11 PF13247.6 CAV19114.1 - 1.2e-25 89.5 11.2 1.2e-25 89.5 11.2 2.0 2 0 0 2 2 2 1 4Fe-4S dicluster domain Fer4_7 PF12838.7 CAV19114.1 - 1.1e-16 61.2 26.4 8.9e-08 32.6 10.5 3.4 2 1 1 3 3 3 3 4Fe-4S dicluster domain Fer4 PF00037.27 CAV19114.1 - 1.2e-12 47.1 35.3 1.3e-06 27.9 1.4 5.5 6 0 0 6 6 6 4 4Fe-4S binding domain Fer4_6 PF12837.7 CAV19114.1 - 1.2e-12 47.3 34.5 9.1e-06 25.5 1.8 4.7 4 1 0 4 4 4 3 4Fe-4S binding domain Fer4_9 PF13187.6 CAV19114.1 - 1.4e-12 47.6 26.2 5.2e-07 29.7 10.5 3.3 2 1 1 3 3 3 3 4Fe-4S dicluster domain Fer4_10 PF13237.6 CAV19114.1 - 3.3e-11 43.1 26.5 1.5e-05 25.0 11.7 3.3 2 1 1 3 3 3 3 4Fe-4S dicluster domain Fer4_2 PF12797.7 CAV19114.1 - 2.2e-08 33.7 33.4 0.00019 21.3 1.2 4.6 4 1 0 4 4 4 3 4Fe-4S binding domain Fer4_16 PF13484.6 CAV19114.1 - 4.9e-08 33.8 23.0 0.26 12.3 0.2 4.4 2 1 1 4 4 4 4 4Fe-4S double cluster binding domain Fer4_3 PF12798.7 CAV19114.1 - 1.1e-07 32.3 41.5 0.03 15.2 1.9 4.3 4 0 0 4 4 4 4 4Fe-4S binding domain Fer4_21 PF14697.6 CAV19114.1 - 0.00011 22.3 32.5 0.00019 21.5 10.8 3.6 3 1 1 4 4 4 2 4Fe-4S dicluster domain Fer4_4 PF12800.7 CAV19114.1 - 0.00011 22.4 37.5 0.0075 16.7 3.0 4.7 4 1 0 4 4 4 3 4Fe-4S binding domain Fer4_8 PF13183.6 CAV19114.1 - 0.00012 22.4 27.9 0.16 12.5 10.6 3.8 2 2 0 2 2 2 2 4Fe-4S dicluster domain Fer4_17 PF13534.6 CAV19114.1 - 0.0085 16.6 29.3 0.095 13.3 1.3 4.5 1 1 4 5 5 5 3 4Fe-4S dicluster domain TAT_signal PF10518.9 CAV19114.1 - 0.011 15.5 5.2 0.026 14.4 5.2 1.7 1 1 0 1 1 1 0 TAT (twin-arginine translocation) pathway signal sequence Fer4_13 PF13370.6 CAV19114.1 - 0.026 15.1 0.6 0.026 15.1 0.6 4.1 2 1 1 3 3 3 0 4Fe-4S single cluster domain of Ferredoxin I Fer4_22 PF17179.4 CAV19114.1 - 0.11 13.3 23.5 0.13 13.1 1.3 3.7 3 1 1 4 4 4 0 4Fe-4S dicluster domain Serine_protease PF18405.1 CAV19114.1 - 0.14 11.3 0.0 0.2 10.8 0.0 1.1 1 0 0 1 1 1 0 Gammaproteobacterial serine protease Fer4_18 PF13746.6 CAV19114.1 - 0.56 10.4 24.9 0.065 13.4 6.9 3.4 1 1 3 4 4 4 0 4Fe-4S dicluster domain Fer4_15 PF13459.6 CAV19114.1 - 4.7 8.0 24.9 29 5.5 5.8 4.0 2 2 1 3 3 3 0 4Fe-4S single cluster domain Cytochrome_C7 PF14522.6 CAV19115.1 - 3.6e-09 36.5 20.5 8.2e-06 25.7 6.7 3.4 1 1 2 3 3 3 3 Cytochrome c7 and related cytochrome c Paired_CXXCH_1 PF09699.10 CAV19115.1 - 1.6e-08 34.1 27.5 9.2e-06 25.3 6.6 4.0 3 1 1 4 4 4 4 Doubled CXXCH motif (Paired_CXXCH_1) Cytochrom_c3_2 PF14537.6 CAV19115.1 - 6.2e-07 29.8 25.7 0.0033 17.8 19.1 3.0 1 1 1 2 2 2 2 Cytochrome c3 Cytochrome_C554 PF13435.6 CAV19115.1 - 1.3e-06 29.2 15.4 0.015 16.2 1.8 3.1 2 1 1 3 3 3 3 Cytochrome c554 and c-prime Cytochrom_CIII PF02085.16 CAV19115.1 - 1.8e-06 28.2 23.4 0.0023 18.2 7.5 3.3 1 1 1 2 2 2 2 Class III cytochrome C family Cytochrom_NNT PF03264.14 CAV19115.1 - 0.00052 19.8 24.5 0.11 12.1 4.4 3.5 1 1 2 3 3 3 3 NapC/NirT cytochrome c family, N-terminal region DZR PF12773.7 CAV19115.1 - 0.043 13.8 15.1 0.56 10.3 1.8 3.3 2 2 0 2 2 2 0 Double zinc ribbon PSCyt1 PF07635.11 CAV19115.1 - 1.5 9.4 20.2 4.6 7.9 0.4 5.2 5 0 0 5 5 5 0 Planctomycete cytochrome C FYVE_2 PF02318.16 CAV19115.1 - 3 8.1 10.4 0.42 10.8 1.9 2.8 2 1 1 3 3 3 0 FYVE-type zinc finger zinc-ribbons_6 PF07191.12 CAV19115.1 - 4.1 7.4 16.1 9 6.4 2.4 3.2 2 2 0 2 2 2 0 zinc-ribbons NapB PF03892.14 CAV19115.1 - 4.4 7.3 22.1 2.4 8.2 0.3 4.6 2 2 1 3 3 3 0 Nitrate reductase cytochrome c-type subunit (NapB) CCP_MauG PF03150.14 CAV19115.1 - 6.8 7.3 22.8 0.81 10.3 0.2 4.6 1 1 2 3 3 3 0 Di-haem cytochrome c peroxidase Zn-ribbon_8 PF09723.10 CAV19115.1 - 7.9 6.7 14.2 2 8.6 1.6 3.5 2 2 1 3 3 3 0 Zinc ribbon domain Cytochrom_C552 PF02335.15 CAV19116.1 - 3.5e-181 602.9 8.3 4.4e-181 602.6 8.3 1.0 1 0 0 1 1 1 1 Cytochrome c552 Cytochrome_C554 PF13435.6 CAV19116.1 - 1.4e-07 32.3 12.2 0.002 19.0 0.1 4.6 4 0 0 4 4 4 2 Cytochrome c554 and c-prime Cytochrome_C7 PF14522.6 CAV19116.1 - 1.1e-05 25.3 11.6 0.077 13.0 4.9 3.5 1 1 2 3 3 3 3 Cytochrome c7 and related cytochrome c Cytochrom_c3_2 PF14537.6 CAV19116.1 - 1.9e-05 25.0 11.3 0.0017 18.8 2.8 3.2 2 1 0 2 2 2 2 Cytochrome c3 Paired_CXXCH_1 PF09699.10 CAV19116.1 - 0.017 14.9 15.5 0.39 10.5 2.9 3.9 2 2 1 3 3 3 0 Doubled CXXCH motif (Paired_CXXCH_1) CCP_MauG PF03150.14 CAV19116.1 - 0.019 15.6 12.3 2.7 8.6 3.5 4.7 3 2 0 3 3 3 0 Di-haem cytochrome c peroxidase Cytochrome_CBB3 PF13442.6 CAV19116.1 - 0.033 14.5 11.5 3.7 7.9 0.1 4.6 2 2 2 4 4 4 0 Cytochrome C oxidase, cbb3-type, subunit III Apocytochr_F_N PF16639.5 CAV19116.1 - 0.85 9.9 3.8 43 4.3 0.2 3.3 2 1 1 3 3 3 0 Apocytochrome F, N-terminal Cytochrom_CIII PF02085.16 CAV19116.1 - 0.99 9.8 14.8 24 5.3 6.2 3.7 1 1 3 4 4 4 0 Class III cytochrome C family DZR PF12773.7 CAV19116.1 - 1.1 9.4 9.0 1.9 8.6 0.3 3.7 3 1 0 3 3 3 0 Double zinc ribbon zf-trcl PF13451.6 CAV19116.1 - 1.9 8.5 10.7 8 6.4 1.0 4.2 4 0 0 4 4 4 0 Probable zinc-ribbon domain Cytochrom_C550 PF14495.6 CAV19116.1 - 2.9 7.6 6.8 2 8.1 0.6 3.1 3 1 1 4 4 4 0 Cytochrome c-550 domain Cytochrom_NNT PF03264.14 CAV19116.1 - 3.1 7.5 17.0 0.32 10.7 0.2 3.9 2 2 1 3 3 3 0 NapC/NirT cytochrome c family, N-terminal region zf-C4pol PF14260.6 CAV19116.1 - 4.3 7.9 8.1 1.2 9.6 0.1 3.1 2 1 0 2 2 2 0 C4-type zinc-finger of DNA polymerase delta Rhodanese PF00581.20 CAV19117.1 - 4e-15 56.2 0.0 4.5e-15 56.1 0.0 1.1 1 0 0 1 1 1 1 Rhodanese-like domain DUF442 PF04273.13 CAV19117.1 - 0.084 13.0 0.0 0.13 12.3 0.0 1.4 1 0 0 1 1 1 0 Putative phosphatase (DUF442) TPR_11 PF13414.6 CAV19118.1 - 4.4e-10 39.1 0.9 2.6e-06 27.0 0.0 3.4 3 1 1 4 4 4 2 TPR repeat TPR_1 PF00515.28 CAV19118.1 - 2.6e-09 36.5 0.4 4.8e-06 26.2 0.0 3.3 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.17 CAV19118.1 - 2.2e-08 33.6 3.6 2.9e-06 26.9 0.0 4.1 5 0 0 5 5 4 1 Tetratricopeptide repeat TPR_19 PF14559.6 CAV19118.1 - 1.1e-06 29.1 0.8 0.00046 20.6 0.1 2.5 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_17 PF13431.6 CAV19118.1 - 1.9e-06 27.8 0.2 0.00075 19.7 0.0 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_16 PF13432.6 CAV19118.1 - 3.8e-06 27.4 0.0 0.00028 21.5 0.0 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_20 PF14561.6 CAV19118.1 - 1.2e-05 25.6 0.1 0.038 14.3 0.0 2.3 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_9 PF13371.6 CAV19118.1 - 1.2e-05 25.4 0.1 7.9e-05 22.7 0.0 2.1 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.6 CAV19118.1 - 1.7e-05 25.2 0.6 0.0032 18.1 0.0 3.3 1 1 2 3 3 3 1 Tetratricopeptide repeat TPR_8 PF13181.6 CAV19118.1 - 5.8e-05 23.0 0.0 0.00044 20.3 0.0 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.6 CAV19118.1 - 0.00058 20.1 0.1 0.067 13.5 0.1 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat DUF4131 PF13567.6 CAV19118.1 - 0.016 14.9 0.0 0.022 14.4 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) TPR_7 PF13176.6 CAV19118.1 - 0.031 14.3 0.0 0.16 12.0 0.0 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF5367 PF17329.2 CAV19118.1 - 0.059 13.5 0.3 0.11 12.6 0.3 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5367) SLATT_1 PF18181.1 CAV19118.1 - 0.064 13.2 0.0 0.14 12.1 0.0 1.6 1 0 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain 1 DNA_topoisoIV PF00521.20 CAV19119.1 - 4e-155 516.9 0.0 5.2e-155 516.5 0.0 1.1 1 0 0 1 1 1 1 DNA gyrase/topoisomerase IV, subunit A DNA_gyraseA_C PF03989.13 CAV19119.1 - 5e-76 250.0 11.8 1.2e-15 56.7 0.0 6.4 6 0 0 6 6 6 6 DNA gyrase C-terminal domain, beta-propeller LEA_6 PF10714.9 CAV19119.1 - 0.06 13.4 0.2 7.7 6.7 0.1 2.8 2 0 0 2 2 2 0 Late embryogenesis abundant protein 18 Methyltransf_23 PF13489.6 CAV19120.1 - 9.3e-23 80.9 0.0 1.2e-22 80.5 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CAV19120.1 - 2.9e-19 69.5 0.0 5.3e-19 68.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CAV19120.1 - 2.8e-17 62.9 0.0 3.6e-17 62.6 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CAV19120.1 - 4e-16 59.5 0.0 5.7e-16 59.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CAV19120.1 - 5.2e-14 52.8 0.0 8.1e-14 52.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 CAV19120.1 - 2.4e-09 36.9 0.0 3e-09 36.6 0.0 1.1 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Ubie_methyltran PF01209.18 CAV19120.1 - 1.1e-08 34.7 0.0 1.4e-08 34.4 0.0 1.1 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family NodS PF05401.11 CAV19120.1 - 1.3e-07 31.4 0.0 1.6e-07 31.1 0.0 1.1 1 0 0 1 1 1 1 Nodulation protein S (NodS) Methyltransf_9 PF08003.11 CAV19120.1 - 6.6e-06 25.3 0.0 9.2e-06 24.8 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) MTS PF05175.14 CAV19120.1 - 7.9e-06 25.5 0.0 1.1e-05 25.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain PrmA PF06325.13 CAV19120.1 - 3.4e-05 23.4 0.0 4.8e-05 22.9 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_32 PF13679.6 CAV19120.1 - 0.00097 19.2 0.0 0.0011 18.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain TehB PF03848.14 CAV19120.1 - 0.0086 15.5 0.0 0.012 15.0 0.0 1.2 1 0 0 1 1 1 1 Tellurite resistance protein TehB MetW PF07021.12 CAV19120.1 - 0.012 15.2 0.0 0.018 14.6 0.0 1.2 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW DREV PF05219.12 CAV19120.1 - 0.023 13.8 0.0 0.041 13.0 0.0 1.4 1 1 0 1 1 1 0 DREV methyltransferase TPMT PF05724.11 CAV19120.1 - 0.027 14.1 0.0 0.055 13.1 0.0 1.5 2 0 0 2 2 2 0 Thiopurine S-methyltransferase (TPMT) GidB PF02527.15 CAV19120.1 - 0.046 13.0 0.0 0.26 10.6 0.0 1.9 1 1 0 1 1 1 0 rRNA small subunit methyltransferase G Methyltransf_18 PF12847.7 CAV19120.1 - 0.071 13.0 0.0 0.11 12.4 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain AdoMet_MTase PF07757.13 CAV19120.1 - 0.13 12.6 0.0 0.25 11.7 0.0 1.5 1 0 0 1 1 1 0 Predicted AdoMet-dependent methyltransferase Ribonuc_red_lgC PF02867.15 CAV19122.1 - 6e-124 414.5 0.0 3.5e-121 405.3 0.0 2.7 2 1 0 2 2 2 1 Ribonucleotide reductase, barrel domain ATP-cone PF03477.16 CAV19122.1 - 5e-19 68.7 0.1 1.6e-18 67.0 0.1 2.0 1 0 0 1 1 1 1 ATP cone domain Ribonuc_red_lgN PF00317.21 CAV19122.1 - 1.3e-11 44.3 0.0 2.8e-11 43.2 0.0 1.6 1 0 0 1 1 1 1 Ribonucleotide reductase, all-alpha domain Ribonuc_red_sm PF00268.21 CAV19123.1 - 4.1e-49 167.5 3.7 5.4e-49 167.1 3.7 1.1 1 0 0 1 1 1 1 Ribonucleotide reductase, small chain Lipase_GDSL_2 PF13472.6 CAV19123.1 - 0.011 16.2 0.0 0.23 11.9 0.0 2.2 2 0 0 2 2 2 0 GDSL-like Lipase/Acylhydrolase family Flavodoxin_5 PF12724.7 CAV19123.1 - 0.026 14.8 0.3 0.068 13.4 0.1 1.7 2 0 0 2 2 2 0 Flavodoxin domain Fer2 PF00111.27 CAV19124.1 - 1.3e-09 37.9 1.3 1.5e-09 37.6 1.3 1.1 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain Fer2_3 PF13085.6 CAV19124.1 - 0.11 12.5 1.2 1 9.4 1.2 2.1 1 1 1 2 2 2 0 2Fe-2S iron-sulfur cluster binding domain MoCF_biosynth PF00994.24 CAV19125.1 - 5.3e-30 104.0 0.0 9.6e-30 103.1 0.0 1.4 1 0 0 1 1 1 1 Probable molybdopterin binding domain CinA PF02464.17 CAV19125.1 - 0.00045 19.8 0.1 0.00086 18.9 0.1 1.5 1 0 0 1 1 1 1 Competence-damaged protein DUF3943 PF13084.6 CAV19126.1 - 2.8e-37 126.8 0.7 5.2e-37 126.0 0.7 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3943) ACT_6 PF13740.6 CAV19127.1 - 9.7e-16 57.5 0.3 8.6e-11 41.7 0.0 2.3 2 0 0 2 2 2 2 ACT domain ACT PF01842.25 CAV19127.1 - 0.00011 21.9 0.2 0.00019 21.1 0.2 1.6 1 0 0 1 1 1 1 ACT domain ACT_4 PF13291.6 CAV19127.1 - 0.0085 16.7 0.3 0.036 14.6 0.1 2.1 2 1 0 2 2 2 1 ACT domain Orn_DAP_Arg_deC PF00278.22 CAV19128.1 - 0.0006 20.0 0.0 0.00096 19.3 0.0 1.4 1 1 0 1 1 1 1 Pyridoxal-dependent decarboxylase, C-terminal sheet domain Sacchrp_dh_NADP PF03435.18 CAV19129.1 - 3.8e-34 117.8 0.2 6e-34 117.1 0.2 1.3 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain Sacchrp_dh_C PF16653.5 CAV19129.1 - 7.1e-31 108.3 0.0 9.3e-31 107.9 0.0 1.1 1 0 0 1 1 1 1 Saccharopine dehydrogenase C-terminal domain Shikimate_DH PF01488.20 CAV19129.1 - 0.014 15.5 0.3 0.027 14.5 0.3 1.5 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Ribul_P_3_epim PF00834.19 CAV19129.1 - 0.11 11.8 0.0 0.24 10.8 0.0 1.5 1 0 0 1 1 1 0 Ribulose-phosphate 3 epimerase family Epimerase PF01370.21 CAV19129.1 - 0.12 11.8 0.0 0.21 11.0 0.0 1.3 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family Aminotran_3 PF00202.21 CAV19130.1 - 4.6e-94 315.4 0.0 8.6e-94 314.5 0.0 1.4 1 0 0 1 1 1 1 Aminotransferase class-III Pyridoxal_deC PF00282.19 CAV19130.1 - 4e-62 210.1 0.4 6e-62 209.5 0.4 1.2 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Beta_elim_lyase PF01212.21 CAV19130.1 - 8.7e-05 21.9 0.5 0.0041 16.4 0.1 2.8 3 0 0 3 3 3 1 Beta-eliminating lyase Aminotran_1_2 PF00155.21 CAV19130.1 - 0.013 14.7 0.0 7 5.7 0.0 3.0 3 1 0 3 3 3 0 Aminotransferase class I and II Aminotran_5 PF00266.19 CAV19130.1 - 0.055 12.4 0.2 0.22 10.5 0.2 2.0 1 1 0 1 1 1 0 Aminotransferase class-V CDP-OH_P_transf PF01066.21 CAV19131.1 - 1.3e-17 64.3 0.3 1.3e-17 64.3 0.3 2.3 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase UvrC_HhH_N PF08459.11 CAV19132.1 - 4.6e-44 150.0 0.0 6.1e-44 149.6 0.0 1.2 1 0 0 1 1 1 1 UvrC Helix-hairpin-helix N-terminal HHH_5 PF14520.6 CAV19132.1 - 3.3e-11 43.6 0.1 7.5e-11 42.5 0.1 1.6 1 0 0 1 1 1 1 Helix-hairpin-helix domain HHH PF00633.23 CAV19132.1 - 7e-09 35.1 0.8 0.00032 20.4 0.0 2.9 3 0 0 3 3 3 2 Helix-hairpin-helix motif HHH_2 PF12826.7 CAV19132.1 - 1.1e-07 31.8 0.0 3.5e-07 30.2 0.0 1.8 2 0 0 2 2 2 1 Helix-hairpin-helix motif HHH_3 PF12836.7 CAV19132.1 - 2.9e-06 27.5 0.6 0.013 15.8 0.0 2.7 3 0 0 3 3 3 2 Helix-hairpin-helix motif 5_3_exonuc PF01367.20 CAV19132.1 - 0.018 15.6 0.0 0.048 14.3 0.0 1.8 1 0 0 1 1 1 0 5'-3' exonuclease, C-terminal SAM fold GIY-YIG PF01541.24 CAV19133.1 - 3.9e-13 49.5 1.0 8.6e-13 48.4 1.0 1.6 1 0 0 1 1 1 1 GIY-YIG catalytic domain UVR PF02151.19 CAV19133.1 - 3.6e-10 39.2 2.0 7.1e-10 38.3 2.0 1.5 1 0 0 1 1 1 1 UvrB/uvrC motif DUF4458 PF14660.6 CAV19133.1 - 0.018 15.3 0.7 0.046 13.9 0.5 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4458) DUF1569 PF07606.11 CAV19133.1 - 0.13 12.3 0.0 0.3 11.1 0.0 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1569) Response_reg PF00072.24 CAV19134.1 - 5.1e-31 107.2 0.1 9.1e-31 106.3 0.0 1.4 2 0 0 2 2 2 1 Response regulator receiver domain GerE PF00196.19 CAV19134.1 - 6.9e-19 67.2 0.2 3.6e-18 64.9 0.0 2.1 2 0 0 2 2 2 1 Bacterial regulatory proteins, luxR family Sigma70_r4_2 PF08281.12 CAV19134.1 - 2e-05 24.2 0.1 7.3e-05 22.4 0.0 1.9 2 0 0 2 2 2 1 Sigma-70, region 4 HTH_23 PF13384.6 CAV19134.1 - 0.0016 18.2 0.0 0.0042 16.8 0.0 1.7 2 0 0 2 2 2 1 Homeodomain-like domain HTH_29 PF13551.6 CAV19134.1 - 0.003 17.5 0.1 0.018 15.1 0.0 2.3 3 0 0 3 3 3 1 Winged helix-turn helix HTH_Mga PF08280.11 CAV19134.1 - 0.0069 16.4 0.0 0.02 14.9 0.0 1.7 1 0 0 1 1 1 1 M protein trans-acting positive regulator (MGA) HTH domain HTH_7 PF02796.15 CAV19134.1 - 0.012 15.6 0.0 0.025 14.7 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain of resolvase HTH_24 PF13412.6 CAV19134.1 - 0.018 14.6 0.0 0.055 13.0 0.0 1.8 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding HTH_Tnp_ISL3 PF13542.6 CAV19134.1 - 0.03 13.8 0.0 0.079 12.4 0.0 1.7 1 0 0 1 1 1 0 Helix-turn-helix domain of transposase family ISL3 HTH_5 PF01022.20 CAV19134.1 - 0.044 13.7 0.0 0.087 12.7 0.0 1.5 1 0 0 1 1 1 0 Bacterial regulatory protein, arsR family Terminase_5 PF06056.12 CAV19134.1 - 0.054 13.4 0.0 0.38 10.7 0.0 2.0 2 0 0 2 2 2 0 Putative ATPase subunit of terminase (gpP-like) HTH_40 PF14493.6 CAV19134.1 - 0.089 13.3 0.1 0.22 12.0 0.0 1.7 2 0 0 2 2 2 0 Helix-turn-helix domain Sigma70_r4 PF04545.16 CAV19134.1 - 0.1 12.1 0.0 0.63 9.6 0.0 2.1 2 0 0 2 2 2 0 Sigma-70, region 4 potato_inhibit PF00280.18 CAV19134.1 - 0.15 12.8 0.0 0.46 11.2 0.0 1.9 1 0 0 1 1 1 0 Potato inhibitor I family DNA_pol_B PF00136.21 CAV19135.1 - 7.6e-43 146.9 0.0 1.6e-42 145.8 0.0 1.4 1 0 0 1 1 1 1 DNA polymerase family B DNA_pol_B_exo1 PF03104.19 CAV19135.1 - 9.3e-22 77.6 0.0 9.3e-20 71.0 0.0 2.2 1 1 0 1 1 1 1 DNA polymerase family B, exonuclease domain DNA_pol_B_2 PF03175.13 CAV19135.1 - 3.9e-06 26.0 0.1 0.003 16.5 0.0 2.3 2 0 0 2 2 2 2 DNA polymerase type B, organellar and viral DUF782 PF05614.11 CAV19135.1 - 0.083 13.3 0.0 0.21 12.0 0.0 1.7 1 0 0 1 1 1 0 Circovirus protein of unknown function (DUF782) NTP_transf_2 PF01909.23 CAV19136.1 - 0.0023 18.2 0.0 0.0042 17.3 0.0 1.4 1 0 0 1 1 1 1 Nucleotidyltransferase domain Polbeta PF18765.1 CAV19136.1 - 0.014 15.5 0.0 0.027 14.6 0.0 1.5 1 0 0 1 1 1 0 Polymerase beta, Nucleotidyltransferase Elong-fact-P_C PF09285.11 CAV19137.1 - 2.4e-21 75.3 2.1 5.1e-21 74.2 0.3 2.6 2 0 0 2 2 2 1 Elongation factor P, C-terminal EFP_N PF08207.12 CAV19137.1 - 4.6e-18 65.0 2.1 6.9e-18 64.4 1.1 1.8 2 0 0 2 2 2 1 Elongation factor P (EF-P) KOW-like domain EFP PF01132.20 CAV19137.1 - 2.4e-11 43.5 2.5 4.2e-11 42.7 2.5 1.4 1 0 0 1 1 1 1 Elongation factor P (EF-P) OB domain DUF440 PF04269.12 CAV19138.1 - 7.7e-45 151.3 1.0 8.6e-45 151.2 1.0 1.0 1 0 0 1 1 1 1 Protein of unknown function, DUF440 SpoU_methylase PF00588.19 CAV19139.1 - 9.7e-19 67.9 0.0 1.3e-18 67.5 0.0 1.1 1 0 0 1 1 1 1 SpoU rRNA Methylase family PseudoU_synth_2 PF00849.22 CAV19140.1 - 2.3e-17 63.6 0.1 5.4e-17 62.3 0.1 1.8 1 1 0 1 1 1 1 RNA pseudouridylate synthase S4 PF01479.25 CAV19140.1 - 4.5e-11 42.3 1.8 6.6e-11 41.8 0.3 2.2 2 0 0 2 2 2 1 S4 domain RHH_1 PF01402.21 CAV19140.1 - 0.35 10.9 3.3 1.3 9.1 3.3 2.0 1 0 0 1 1 1 0 Ribbon-helix-helix protein, copG family Sua5_yciO_yrdC PF01300.18 CAV19141.1 - 7.9e-48 162.3 0.0 1e-47 162.0 0.0 1.1 1 0 0 1 1 1 1 Telomere recombination PHP PF02811.19 CAV19142.1 - 1.2e-08 35.4 0.0 1.7e-08 35.0 0.0 1.2 1 0 0 1 1 1 1 PHP domain Chorismate_bind PF00425.18 CAV19143.1 - 3.6e-87 292.2 0.1 1.7e-86 290.0 0.0 1.9 2 0 0 2 2 2 1 chorismate binding enzyme Anth_synt_I_N PF04715.13 CAV19143.1 - 2.4e-17 63.5 0.2 2.9e-16 60.0 0.1 2.5 2 0 0 2 2 2 1 Anthranilate synthase component I, N terminal region GATase PF00117.28 CAV19144.1 - 1.1e-43 149.2 0.0 1.3e-43 149.0 0.0 1.0 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.13 CAV19144.1 - 7.4e-09 35.7 3.3 2.2e-07 30.9 3.3 2.2 1 1 0 1 1 1 1 Peptidase C26 Glycos_transf_3 PF00591.21 CAV19145.1 - 8.3e-104 346.6 2.8 1.2e-103 346.1 2.8 1.2 1 0 0 1 1 1 1 Glycosyl transferase family, a/b domain Glycos_trans_3N PF02885.17 CAV19145.1 - 5.1e-19 67.9 1.9 4.4e-16 58.5 0.3 3.0 2 1 1 3 3 3 2 Glycosyl transferase family, helical bundle domain IGPS PF00218.21 CAV19146.1 - 4.2e-94 314.5 0.8 6e-94 313.9 0.8 1.2 1 0 0 1 1 1 1 Indole-3-glycerol phosphate synthase PRAI PF00697.22 CAV19146.1 - 8e-54 182.4 0.2 1.2e-53 181.8 0.2 1.3 1 0 0 1 1 1 1 N-(5'phosphoribosyl)anthranilate (PRA) isomerase QRPTase_C PF01729.19 CAV19146.1 - 0.0028 17.5 0.5 0.02 14.6 0.2 2.3 2 0 0 2 2 2 1 Quinolinate phosphoribosyl transferase, C-terminal domain PALP PF00291.25 CAV19147.1 - 6.7e-48 163.6 0.7 8.1e-48 163.3 0.7 1.1 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Phage-MuB_C PF09077.11 CAV19147.1 - 0.056 13.3 0.1 0.48 10.3 0.1 2.2 2 0 0 2 2 2 0 Mu B transposition protein, C terminal MtrF PF09472.10 CAV19147.1 - 0.096 12.1 0.0 4.7 6.7 0.0 2.4 2 0 0 2 2 2 0 Tetrahydromethanopterin S-methyltransferase, F subunit (MtrF) Trp_syntA PF00290.20 CAV19148.1 - 4.9e-99 330.4 0.2 5.5e-99 330.2 0.2 1.0 1 0 0 1 1 1 1 Tryptophan synthase alpha chain Amidohydro_2 PF04909.14 CAV19148.1 - 0.011 15.5 0.0 0.03 14.1 0.0 1.9 2 1 0 2 2 2 0 Amidohydrolase HMGL-like PF00682.19 CAV19148.1 - 0.047 13.2 0.0 0.45 10.0 0.0 2.6 1 1 0 1 1 1 0 HMGL-like His_biosynth PF00977.21 CAV19148.1 - 0.053 13.0 0.0 0.64 9.4 0.0 2.1 2 0 0 2 2 2 0 Histidine biosynthesis protein Band_7 PF01145.25 CAV19149.1 - 5.4e-35 121.0 2.2 8.6e-35 120.3 2.2 1.3 1 0 0 1 1 1 1 SPFH domain / Band 7 family Band_7_1 PF13421.6 CAV19149.1 - 0.00015 21.5 0.4 0.00033 20.4 0.4 1.6 1 1 0 1 1 1 1 SPFH domain-Band 7 family DUF4228 PF14009.6 CAV19149.1 - 0.035 14.5 0.0 0.063 13.7 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4228) DUF4424 PF14415.6 CAV19149.1 - 0.048 12.9 0.2 0.079 12.2 0.1 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4424) Nup54 PF13874.6 CAV19149.1 - 0.27 11.3 5.7 0.45 10.6 5.7 1.4 1 0 0 1 1 1 0 Nucleoporin complex subunit 54 NfeD PF01957.18 CAV19150.1 - 1e-15 57.9 1.6 2.9e-15 56.4 1.6 1.7 1 0 0 1 1 1 1 NfeD-like C-terminal, partner-binding CLP_protease PF00574.23 CAV19150.1 - 0.11 12.4 0.1 0.17 11.7 0.1 1.4 1 0 0 1 1 1 0 Clp protease Neurensin PF14927.6 CAV19150.1 - 0.88 9.3 5.8 1.8 8.2 4.0 2.2 2 0 0 2 2 2 0 Neurensin SDF PF00375.18 CAV19151.1 - 9.5e-119 396.9 47.6 1.1e-118 396.7 47.6 1.0 1 0 0 1 1 1 1 Sodium:dicarboxylate symporter family Sugarporin_N PF11471.8 CAV19152.1 - 0.002 18.0 2.7 0.0036 17.2 2.7 1.4 1 0 0 1 1 1 1 Maltoporin periplasmic N-terminal extension HTH_Tnp_1 PF01527.20 CAV19152.1 - 0.074 13.4 3.0 0.28 11.5 3.0 2.0 1 1 0 1 1 1 0 Transposase DUF3323 PF11796.8 CAV19152.1 - 0.23 11.3 3.0 0.4 10.5 1.2 1.8 1 1 1 2 2 2 0 Protein of unknown function N-terminus (DUF3323) rve PF00665.26 CAV19153.1 - 1.8e-26 92.6 0.1 6.2e-26 90.9 0.0 1.8 2 0 0 2 2 2 1 Integrase core domain rve_3 PF13683.6 CAV19153.1 - 2.6e-19 68.8 0.0 5.3e-19 67.8 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain DDE_Tnp_IS240 PF13610.6 CAV19153.1 - 0.0001 22.5 0.2 0.00018 21.7 0.2 1.4 1 0 0 1 1 1 1 DDE domain HTH_21 PF13276.6 CAV19153.1 - 0.015 15.4 1.6 0.043 14.0 1.0 2.1 2 0 0 2 2 2 0 HTH-like domain rve_2 PF13333.6 CAV19153.1 - 0.051 13.7 0.1 0.1 12.8 0.1 1.5 1 0 0 1 1 1 0 Integrase core domain RlmM_FDX PF18125.1 CAV19153.1 - 0.13 12.8 0.0 0.47 11.0 0.0 1.9 1 0 0 1 1 1 0 RlmM ferredoxin-like domain Methyltrans_SAM PF10672.9 CAV19154.1 - 7.6e-180 596.3 0.0 8.6e-180 596.1 0.0 1.0 1 0 0 1 1 1 1 S-adenosylmethionine-dependent methyltransferase Cons_hypoth95 PF03602.15 CAV19154.1 - 1.4e-06 28.1 0.0 2.2e-06 27.4 0.0 1.2 1 0 0 1 1 1 1 Conserved hypothetical protein 95 Methyltransf_31 PF13847.6 CAV19154.1 - 0.0006 19.6 0.0 0.00091 19.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 CAV19154.1 - 0.016 14.7 0.0 0.026 14.1 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase small domain PseudoU_synth_2 PF00849.22 CAV19155.1 - 1.2e-27 97.0 0.0 1.5e-27 96.6 0.0 1.2 1 0 0 1 1 1 1 RNA pseudouridylate synthase MCPsignal PF00015.21 CAV19156.1 - 3.3e-44 150.7 23.8 3.3e-44 150.7 23.8 3.5 2 1 2 4 4 4 3 Methyl-accepting chemotaxis protein (MCP) signalling domain HAMP PF00672.25 CAV19156.1 - 5.2e-11 42.8 0.3 5.2e-11 42.8 0.3 3.4 4 1 0 4 4 4 1 HAMP domain DUF948 PF06103.11 CAV19156.1 - 0.0054 17.0 0.9 0.0054 17.0 0.9 5.7 2 1 2 4 4 4 1 Bacterial protein of unknown function (DUF948) CHASE3 PF05227.13 CAV19156.1 - 0.01 15.8 0.6 0.01 15.8 0.6 4.4 3 2 2 5 5 5 0 CHASE3 domain IFT57 PF10498.9 CAV19156.1 - 0.12 11.3 16.0 0.27 10.1 0.4 3.5 3 1 1 4 4 4 0 Intra-flagellar transport protein 57 DUF4375 PF14300.6 CAV19156.1 - 0.21 11.8 1.9 61 3.9 0.2 3.5 2 2 2 4 4 4 0 Domain of unknown function (DUF4375) GAT PF03127.14 CAV19156.1 - 0.27 11.6 4.5 0.46 10.8 0.0 3.5 4 1 0 4 4 4 0 GAT domain Spectrin PF00435.21 CAV19156.1 - 2.4 8.7 6.4 23 5.5 0.1 4.0 3 1 1 4 4 4 0 Spectrin repeat Sec5 PF15469.6 CAV19156.1 - 6.9 6.4 9.0 1.2 8.9 0.3 3.2 3 2 1 4 4 4 0 Exocyst complex component Sec5 SNF PF00209.18 CAV19157.1 - 1.6e-55 188.8 37.6 1.4e-32 113.1 21.6 2.1 2 0 0 2 2 2 2 Sodium:neurotransmitter symporter family PLDc_2 PF13091.6 CAV19158.1 - 5.2e-42 142.9 0.0 4.6e-24 84.8 0.0 2.2 2 0 0 2 2 2 2 PLD-like domain PLDc PF00614.22 CAV19158.1 - 1.3e-15 56.9 0.0 1.5e-06 28.1 0.0 2.4 2 0 0 2 2 2 2 Phospholipase D Active site motif PLDc_N PF13396.6 CAV19158.1 - 2.6e-07 30.4 5.4 5.4e-07 29.4 5.4 1.6 1 0 0 1 1 1 1 Phospholipase_D-nuclease N-terminal Regulator_TrmB PF11495.8 CAV19158.1 - 0.00024 20.4 0.0 0.41 9.8 0.0 2.2 2 0 0 2 2 2 2 Archaeal transcriptional regulator TrmB Glyoxalase_2 PF12681.7 CAV19158.1 - 0.014 15.3 1.9 0.021 14.7 0.3 2.0 2 0 0 2 2 2 0 Glyoxalase-like domain PP_kinase_C_1 PF17941.1 CAV19158.1 - 0.056 13.0 0.0 0.29 10.7 0.0 2.0 2 0 0 2 2 2 0 Polyphosphate kinase C-terminal domain 1 Cys_Met_Meta_PP PF01053.20 CAV19159.1 - 1.6e-117 392.3 0.0 1.9e-117 392.1 0.0 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_5 PF00266.19 CAV19159.1 - 1.3e-06 27.6 0.0 2.8e-06 26.5 0.0 1.5 1 0 0 1 1 1 1 Aminotransferase class-V Aminotran_1_2 PF00155.21 CAV19159.1 - 3.8e-05 23.0 0.1 5.2e-05 22.6 0.1 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II GDC-P PF02347.16 CAV19159.1 - 0.0051 15.7 0.0 0.0079 15.1 0.0 1.2 1 0 0 1 1 1 1 Glycine cleavage system P-protein Clc-like PF07062.12 CAV19160.1 - 0.018 14.5 0.0 0.024 14.1 0.0 1.2 1 0 0 1 1 1 0 Clc-like Lipocalin_4 PF13648.6 CAV19160.1 - 0.034 15.1 0.6 0.055 14.4 0.5 1.5 1 1 0 1 1 1 0 Lipocalin-like domain Trans_reg_C PF00486.28 CAV19161.1 - 3.2e-10 39.9 0.0 6.2e-10 39.0 0.0 1.5 1 0 0 1 1 1 1 Transcriptional regulatory protein, C terminal Adenine_glyco PF03352.13 CAV19162.1 - 1.2e-73 246.6 0.3 1.4e-73 246.4 0.3 1.0 1 0 0 1 1 1 1 Methyladenine glycosylase DUF190 PF02641.15 CAV19162.1 - 0.17 12.3 0.0 0.3 11.5 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized ACR, COG1993 ACR_tran PF00873.19 CAV19163.1 - 1.4e-168 562.7 0.4 1.6e-168 562.5 0.4 1.0 1 0 0 1 1 1 1 AcrB/AcrD/AcrF family SecD_SecF PF02355.16 CAV19163.1 - 5.7 6.3 21.5 2.2 7.6 9.0 2.5 2 0 0 2 2 2 0 Protein export membrane protein Biotin_lipoyl_2 PF13533.6 CAV19164.1 - 3.6e-15 55.5 2.3 5.5e-12 45.3 0.1 2.6 2 0 0 2 2 2 2 Biotin-lipoyl like HlyD_3 PF13437.6 CAV19164.1 - 4.9e-12 46.5 3.9 1e-06 29.4 1.9 3.0 2 1 0 2 2 2 2 HlyD family secretion protein HlyD_D23 PF16576.5 CAV19164.1 - 1.5e-11 43.9 0.4 3.4e-11 42.8 0.4 1.5 1 0 0 1 1 1 1 Barrel-sandwich domain of CusB or HlyD membrane-fusion Biotin_lipoyl PF00364.22 CAV19164.1 - 3.3e-07 30.0 0.2 0.04 13.7 0.0 3.2 3 0 0 3 3 3 2 Biotin-requiring enzyme PTS_EIIA_1 PF00358.20 CAV19164.1 - 0.00041 20.1 0.1 0.0031 17.3 0.0 2.3 2 0 0 2 2 2 1 phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1 Peptidase_M23 PF01551.22 CAV19164.1 - 0.021 15.0 0.2 0.75 10.0 0.0 2.6 2 0 0 2 2 2 0 Peptidase family M23 CE2_N PF17996.1 CAV19164.1 - 0.026 14.5 0.2 0.15 12.0 0.0 2.1 2 0 0 2 2 2 0 Carbohydrate esterase 2 N-terminal PYNP_C PF07831.13 CAV19164.1 - 0.11 12.1 0.4 1.3 8.7 0.0 2.4 2 0 0 2 2 2 0 Pyrimidine nucleoside phosphorylase C-terminal domain HlyD_3 PF13437.6 CAV19165.1 - 5.2e-14 52.8 0.1 1.6e-09 38.4 0.0 2.6 2 0 0 2 2 2 2 HlyD family secretion protein Biotin_lipoyl_2 PF13533.6 CAV19165.1 - 1.7e-10 40.6 0.1 1.7e-10 40.6 0.1 2.5 3 0 0 3 3 3 1 Biotin-lipoyl like HlyD_D23 PF16576.5 CAV19165.1 - 8.8e-10 38.2 0.1 1.4e-09 37.5 0.1 1.3 1 0 0 1 1 1 1 Barrel-sandwich domain of CusB or HlyD membrane-fusion PTS_EIIA_1 PF00358.20 CAV19165.1 - 0.0051 16.6 0.0 1.7 8.4 0.0 2.5 2 0 0 2 2 2 2 phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1 Biotin_lipoyl PF00364.22 CAV19165.1 - 0.071 12.9 0.2 3 7.8 0.0 2.9 3 0 0 3 3 3 0 Biotin-requiring enzyme DUF2118 PF09891.9 CAV19165.1 - 0.15 12.0 0.4 2.5 8.0 0.0 2.5 2 1 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2118) LPAM_2 PF13627.6 CAV19165.1 - 1.2 9.0 4.8 2.1 8.3 4.8 1.4 1 0 0 1 1 1 0 Prokaryotic lipoprotein-attachment site PspC PF04024.12 CAV19166.1 - 1.9e-15 56.4 0.5 2.6e-15 55.9 0.5 1.2 1 0 0 1 1 1 1 PspC domain PspB PF06667.12 CAV19167.1 - 9.3e-34 115.3 0.1 1e-33 115.2 0.1 1.0 1 0 0 1 1 1 1 Phage shock protein B TssO PF17561.2 CAV19167.1 - 0.035 14.2 0.0 0.039 14.0 0.0 1.0 1 0 0 1 1 1 0 Type VI secretion system, TssO CcmH PF03918.14 CAV19167.1 - 0.036 13.3 0.0 0.049 12.9 0.0 1.2 1 0 0 1 1 1 0 Cytochrome C biogenesis protein Syndecan PF01034.20 CAV19167.1 - 0.041 13.8 0.0 0.05 13.5 0.0 1.2 1 0 0 1 1 1 0 Syndecan domain YPEB PF14620.6 CAV19167.1 - 0.064 12.6 0.5 0.076 12.3 0.5 1.0 1 0 0 1 1 1 0 YpeB sporulation ASFV_J13L PF05568.11 CAV19167.1 - 0.087 12.6 0.0 0.091 12.5 0.0 1.1 1 0 0 1 1 1 0 African swine fever virus J13L protein Vpu PF00558.19 CAV19167.1 - 0.1 12.4 0.0 0.12 12.1 0.0 1.2 1 0 0 1 1 1 0 Vpu protein Sugar_tr PF00083.24 CAV19167.1 - 0.11 11.3 0.0 0.12 11.2 0.0 1.0 1 0 0 1 1 1 0 Sugar (and other) transporter Na_sulph_symp PF00939.19 CAV19167.1 - 0.14 11.1 0.0 0.15 11.0 0.0 1.0 1 0 0 1 1 1 0 Sodium:sulfate symporter transmembrane region PspA_IM30 PF04012.12 CAV19168.1 - 9.2e-62 208.5 30.4 1.1e-61 208.3 30.4 1.0 1 0 0 1 1 1 1 PspA/IM30 family BCOR PF15808.5 CAV19168.1 - 0.0072 16.6 5.2 0.011 16.0 5.2 1.3 1 0 0 1 1 1 1 BCL-6 co-repressor, non-ankyrin-repeat region Arteri_nsp7a PF16749.5 CAV19168.1 - 0.038 14.2 5.3 0.45 10.7 0.6 2.6 1 1 1 2 2 2 0 Arterivirus nonstructural protein 7 alpha Cupin_8 PF13621.6 CAV19168.1 - 0.12 12.0 8.2 0.038 13.7 4.0 1.8 1 1 1 2 2 2 0 Cupin-like domain zf-C4H2 PF10146.9 CAV19168.1 - 0.4 11.0 21.0 0.54 10.5 11.0 2.4 1 1 1 2 2 2 0 Zinc finger-containing protein Baculo_PEP_C PF04513.12 CAV19168.1 - 0.42 10.6 15.2 0.45 10.5 7.4 2.6 1 1 2 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus XRN_M PF17846.1 CAV19168.1 - 5.1 5.9 16.1 0.73 8.7 11.2 1.8 1 1 1 2 2 2 0 Xrn1 helical domain TraF_2 PF13729.6 CAV19168.1 - 5.8 6.2 8.7 1.1 8.6 1.6 2.3 1 1 1 2 2 2 0 F plasmid transfer operon, TraF, protein ParB PF08775.10 CAV19168.1 - 6.1 7.3 15.6 1.1 9.7 7.4 2.6 1 1 0 2 2 2 0 ParB family FlaC_arch PF05377.11 CAV19168.1 - 6.4 7.3 17.8 17 5.9 0.2 4.6 3 3 2 5 5 5 0 Flagella accessory protein C (FlaC) Sigma54_activat PF00158.26 CAV19169.1 - 2.1e-57 193.5 0.0 2.8e-57 193.1 0.0 1.2 1 0 0 1 1 1 1 Sigma-54 interaction domain Sigma54_activ_2 PF14532.6 CAV19169.1 - 4.6e-18 65.7 0.0 8.6e-18 64.8 0.0 1.5 1 0 0 1 1 1 1 Sigma-54 interaction domain AAA_5 PF07728.14 CAV19169.1 - 7.4e-08 32.5 0.0 1.2e-07 31.9 0.0 1.3 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) HTH_8 PF02954.19 CAV19169.1 - 8.1e-08 31.9 0.2 1.7e-07 30.9 0.2 1.6 1 0 0 1 1 1 1 Bacterial regulatory protein, Fis family Mg_chelatase PF01078.21 CAV19169.1 - 1.6e-06 27.7 0.0 0.0048 16.3 0.0 2.1 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_2 PF07724.14 CAV19169.1 - 6.7e-06 26.3 0.0 2.5e-05 24.5 0.0 1.8 1 1 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA PF00004.29 CAV19169.1 - 0.0004 20.8 0.0 0.00074 19.9 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DUF2316 PF10078.9 CAV19169.1 - 0.0035 17.5 0.3 0.56 10.5 0.0 2.5 2 0 0 2 2 2 1 Uncharacterized protein conserved in bacteria (DUF2316) HTH_28 PF13518.6 CAV19169.1 - 0.01 15.9 0.0 0.021 14.9 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_3 PF01381.22 CAV19169.1 - 0.011 15.7 0.4 0.027 14.5 0.4 1.7 1 0 0 1 1 1 0 Helix-turn-helix AAA_7 PF12775.7 CAV19169.1 - 0.041 13.4 0.0 0.24 10.9 0.0 1.9 2 0 0 2 2 2 0 P-loop containing dynein motor region HTH_23 PF13384.6 CAV19169.1 - 0.065 13.0 0.0 0.17 11.8 0.0 1.6 1 0 0 1 1 1 0 Homeodomain-like domain SBP_bac_5 PF00496.22 CAV19170.1 - 2.2e-82 277.0 0.3 2.6e-82 276.8 0.3 1.0 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 5 Middle DUF4968 PF16338.5 CAV19170.1 - 0.074 13.4 0.7 2.7 8.4 0.1 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4968) BPD_transp_1 PF00528.22 CAV19171.1 - 1.7e-42 145.3 10.8 1.7e-42 145.3 10.8 1.7 2 0 0 2 2 2 1 Binding-protein-dependent transport system inner membrane component DUF846 PF05832.12 CAV19171.1 - 6.7 6.7 9.4 1.2 9.2 0.1 2.7 3 0 0 3 3 3 0 Eukaryotic protein of unknown function (DUF846) BPD_transp_1 PF00528.22 CAV19172.1 - 9.7e-21 74.3 14.1 9.7e-21 74.3 14.1 2.4 1 1 1 3 3 3 1 Binding-protein-dependent transport system inner membrane component OppC_N PF12911.7 CAV19172.1 - 6e-14 51.8 0.1 6e-14 51.8 0.1 3.5 4 1 0 4 4 4 1 N-terminal TM domain of oligopeptide transport permease C CPP1-like PF11833.8 CAV19172.1 - 5.1 6.7 6.8 13 5.4 6.8 1.7 1 0 0 1 1 1 0 Protein CHAPERONE-LIKE PROTEIN OF POR1-like ABC_tran PF00005.27 CAV19173.1 - 1.9e-27 96.4 0.0 1e-24 87.6 0.0 2.1 2 0 0 2 2 2 2 ABC transporter oligo_HPY PF08352.12 CAV19173.1 - 1.8e-15 57.2 0.1 5.9e-15 55.5 0.1 1.9 2 0 0 2 2 2 1 Oligopeptide/dipeptide transporter, C-terminal region AAA_21 PF13304.6 CAV19173.1 - 3.5e-05 23.8 0.2 0.044 13.6 0.1 2.3 1 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_22 PF13401.6 CAV19173.1 - 4.9e-05 23.6 0.1 0.00094 19.5 0.1 2.1 1 1 0 1 1 1 1 AAA domain SMC_N PF02463.19 CAV19173.1 - 0.0018 17.7 0.0 0.0025 17.3 0.0 1.2 1 0 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA PF00004.29 CAV19173.1 - 0.02 15.3 0.0 0.15 12.5 0.0 2.1 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) BacteriocIIc_cy PF12173.8 CAV19173.1 - 0.051 13.8 0.1 1.1 9.5 0.0 2.3 2 0 0 2 2 2 0 Bacteriocin class IIc cyclic gassericin A-like IstB_IS21 PF01695.17 CAV19173.1 - 0.13 12.0 0.1 2.3 7.9 0.0 2.1 2 0 0 2 2 2 0 IstB-like ATP binding protein Sigma54_activat PF00158.26 CAV19173.1 - 0.13 12.0 0.2 0.44 10.2 0.0 1.8 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_19 PF13245.6 CAV19173.1 - 0.13 12.6 0.0 0.33 11.3 0.0 1.6 1 1 0 1 1 1 0 AAA domain ThiI PF02568.14 CAV19173.1 - 0.14 11.7 0.1 0.21 11.2 0.1 1.2 1 0 0 1 1 1 0 Thiamine biosynthesis protein (ThiI) DUF2791 PF10923.8 CAV19173.1 - 0.17 10.7 0.0 1.1 8.1 0.0 1.9 2 0 0 2 2 2 0 P-loop Domain of unknown function (DUF2791) AAA_29 PF13555.6 CAV19173.1 - 0.19 11.5 0.0 0.45 10.3 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain ABC_tran PF00005.27 CAV19174.1 - 1.6e-31 109.6 0.0 2.5e-31 109.0 0.0 1.3 1 0 0 1 1 1 1 ABC transporter AAA_22 PF13401.6 CAV19174.1 - 5.4e-07 30.0 0.0 9.8e-07 29.1 0.0 1.4 1 1 0 1 1 1 1 AAA domain RsgA_GTPase PF03193.16 CAV19174.1 - 9.4e-05 22.4 0.1 0.00042 20.3 0.0 1.9 2 0 0 2 2 2 1 RsgA GTPase AAA PF00004.29 CAV19174.1 - 0.00085 19.8 0.0 0.0026 18.2 0.0 1.8 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_15 PF13175.6 CAV19174.1 - 0.0011 18.8 0.0 0.0011 18.8 0.0 1.2 1 0 0 1 1 1 1 AAA ATPase domain AAA_21 PF13304.6 CAV19174.1 - 0.0013 18.6 0.0 0.0041 17.0 0.0 1.7 2 0 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 CAV19174.1 - 0.0066 16.2 0.0 0.011 15.4 0.0 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain SMC_N PF02463.19 CAV19174.1 - 0.013 15.0 0.3 0.07 12.6 0.3 2.0 1 1 0 1 1 1 0 RecF/RecN/SMC N terminal domain Zeta_toxin PF06414.12 CAV19174.1 - 0.028 13.7 0.0 0.048 12.9 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin AAA_16 PF13191.6 CAV19174.1 - 0.039 14.3 0.0 0.054 13.9 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain AAA_33 PF13671.6 CAV19174.1 - 0.05 13.8 0.0 0.11 12.6 0.0 1.7 2 0 0 2 2 2 0 AAA domain AAA_23 PF13476.6 CAV19174.1 - 0.051 14.1 0.0 0.082 13.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.6 CAV19174.1 - 0.076 13.3 0.0 1.4 9.2 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_13 PF13166.6 CAV19174.1 - 0.1 11.2 0.0 0.14 10.8 0.0 1.1 1 0 0 1 1 1 0 AAA domain MMR_HSR1 PF01926.23 CAV19174.1 - 0.14 12.2 0.0 0.29 11.2 0.0 1.6 1 0 0 1 1 1 0 50S ribosome-binding GTPase DUF2927 PF11150.8 CAV19175.1 - 2.6e-63 213.8 0.0 3.1e-63 213.6 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2927) DUF2750 PF11042.8 CAV19177.1 - 1e-36 125.1 2.6 1.2e-36 124.8 2.6 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2750) DHH PF01368.20 CAV19178.1 - 3.1e-22 78.7 0.2 6.4e-22 77.7 0.1 1.6 2 0 0 2 2 2 1 DHH family DHHA2 PF02833.14 CAV19178.1 - 1.7e-14 54.2 0.1 3.1e-14 53.4 0.1 1.4 1 0 0 1 1 1 1 DHHA2 domain Img2 PF05046.14 CAV19178.1 - 0.012 15.9 0.1 0.073 13.4 0.0 2.1 2 0 0 2 2 2 0 Mitochondrial large subunit ribosomal protein (Img2) ArsP_2 PF11449.8 CAV19179.1 - 1.7e-158 527.6 10.3 1.9e-158 527.4 10.3 1.0 1 0 0 1 1 1 1 Putative, 10TM heavy-metal exporter GPI2 PF06432.11 CAV19179.1 - 1.6 8.2 8.5 0.14 11.6 2.9 2.0 2 1 1 3 3 3 0 Phosphatidylinositol N-acetylglucosaminyltransferase Molybdopterin PF00384.22 CAV19180.1 - 1.6e-80 271.2 0.1 2e-80 270.9 0.1 1.1 1 0 0 1 1 1 1 Molybdopterin oxidoreductase Molydop_binding PF01568.21 CAV19180.1 - 1e-24 86.7 0.0 2.6e-24 85.4 0.0 1.7 1 0 0 1 1 1 1 Molydopterin dinucleotide binding domain Molybdopterin_N PF18364.1 CAV19180.1 - 2.2e-15 56.4 0.4 5.4e-15 55.1 0.0 2.0 2 0 0 2 2 2 1 Molybdopterin oxidoreductase N-terminal domain PUA_3 PF17785.1 CAV19180.1 - 0.0013 18.5 0.0 0.0037 17.0 0.0 1.8 1 0 0 1 1 1 1 PUA-like domain TAT_signal PF10518.9 CAV19180.1 - 0.011 15.6 4.4 0.027 14.3 4.4 1.8 1 0 0 1 1 1 0 TAT (twin-arginine translocation) pathway signal sequence Cytochrom_NNT PF03264.14 CAV19181.1 - 2.9e-74 248.5 7.4 6.6e-73 244.1 5.1 2.1 2 0 0 2 2 2 1 NapC/NirT cytochrome c family, N-terminal region Cytochrome_C7 PF14522.6 CAV19181.1 - 2.1e-08 34.0 14.9 0.00016 21.6 0.9 4.1 3 1 1 4 4 4 4 Cytochrome c7 and related cytochrome c Cytochrom_c3_2 PF14537.6 CAV19181.1 - 2.4e-07 31.1 16.6 0.0048 17.3 2.3 3.3 3 0 0 3 3 3 2 Cytochrome c3 Paired_CXXCH_1 PF09699.10 CAV19181.1 - 3e-05 23.7 17.9 0.025 14.3 2.1 4.4 4 0 0 4 4 4 3 Doubled CXXCH motif (Paired_CXXCH_1) Cytochrom_CIII PF02085.16 CAV19181.1 - 5.3e-05 23.5 15.7 0.023 15.0 1.5 3.3 3 0 0 3 3 3 2 Class III cytochrome C family DHC PF09626.10 CAV19181.1 - 0.002 19.0 17.6 0.0028 18.5 0.1 4.7 3 1 2 5 5 5 2 Dihaem cytochrome c CCP_MauG PF03150.14 CAV19181.1 - 0.055 14.1 16.2 17 6.0 3.9 5.0 3 2 1 4 4 4 0 Di-haem cytochrome c peroxidase Cytochrome_CBB3 PF13442.6 CAV19181.1 - 0.22 11.9 17.8 0.24 11.7 0.0 4.9 3 2 1 4 4 4 0 Cytochrome C oxidase, cbb3-type, subunit III GSu_C4xC__C2xCH PF09698.10 CAV19181.1 - 0.24 12.2 20.1 0.57 11.0 0.1 4.7 4 1 1 5 5 5 0 Geobacter CxxxxCH...CXXCH motif (GSu_C4xC__C2xCH) Cytochrom_C1 PF02167.15 CAV19181.1 - 0.43 10.3 5.6 6.5 6.4 0.2 3.1 3 0 0 3 3 3 0 Cytochrome C1 family Cytochrom_C552 PF02335.15 CAV19181.1 - 0.53 9.1 15.2 0.011 14.7 4.5 2.8 2 1 1 3 3 3 0 Cytochrome c552 PSCyt3 PF07627.11 CAV19181.1 - 0.64 10.3 18.8 7.3 6.9 0.6 4.8 2 1 3 5 5 5 0 Protein of unknown function (DUF1588) DUF866 PF05907.13 CAV19181.1 - 0.74 9.7 6.0 3.1 7.7 3.2 2.3 1 1 1 2 2 2 0 Eukaryotic protein of unknown function (DUF866) zf-C4pol PF14260.6 CAV19181.1 - 1 9.8 9.5 6 7.4 0.6 3.5 3 1 0 3 3 3 0 C4-type zinc-finger of DNA polymerase delta Zn_Tnp_IS1595 PF12760.7 CAV19181.1 - 2 8.4 9.7 1.7 8.7 0.7 3.6 3 1 0 3 3 3 0 Transposase zinc-ribbon domain Cytochrom_C PF00034.21 CAV19181.1 - 8.2 7.6 17.0 2.6 9.3 0.1 4.4 3 2 0 3 3 3 0 Cytochrome c NapE PF06796.11 CAV19182.1 - 6e-24 83.3 1.6 6.5e-24 83.2 1.6 1.0 1 0 0 1 1 1 1 Periplasmic nitrate reductase protein NapE UPF0014 PF03649.13 CAV19183.1 - 9.2e-75 251.1 22.8 1e-74 250.9 22.8 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0014) Form_Nir_trans PF01226.17 CAV19185.1 - 5.2e-76 255.1 24.4 5.9e-76 254.9 24.4 1.0 1 0 0 1 1 1 1 Formate/nitrite transporter BRE1 PF08647.11 CAV19186.1 - 0.032 14.3 11.7 0.049 13.7 8.9 2.8 2 2 1 3 3 3 0 BRE1 E3 ubiquitin ligase NitrOD5 PF11537.8 CAV19186.1 - 0.064 13.4 1.0 0.25 11.5 0.2 2.4 2 0 0 2 2 2 0 Nitrosopumilus output domain 5 CLZ PF16526.5 CAV19186.1 - 0.07 13.5 6.2 3.2 8.2 1.5 3.4 1 1 1 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Phycoerythr_ab PF02972.14 CAV19186.1 - 0.075 12.8 0.0 0.25 11.2 0.0 1.9 1 0 0 1 1 1 0 Phycoerythrin, alpha/beta chain PI3K_P85_iSH2 PF16454.5 CAV19186.1 - 0.24 11.0 10.5 1.3 8.6 9.0 2.8 2 2 0 2 2 2 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain ATG16 PF08614.11 CAV19186.1 - 0.24 11.6 13.3 0.023 15.0 6.6 2.6 2 1 0 2 2 2 0 Autophagy protein 16 (ATG16) DUF4200 PF13863.6 CAV19186.1 - 0.38 11.2 7.3 0.21 12.0 4.2 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF4200) FlxA PF14282.6 CAV19186.1 - 0.78 9.8 13.5 0.053 13.5 7.7 2.1 2 0 0 2 2 2 0 FlxA-like protein XhlA PF10779.9 CAV19186.1 - 1.7 8.9 10.2 2.3 8.5 1.6 3.7 3 1 1 4 4 4 0 Haemolysin XhlA CEP209_CC5 PF16574.5 CAV19186.1 - 7.3 6.8 11.4 1.7 8.8 6.6 2.5 2 1 1 3 3 3 0 Coiled-coil region of centrosome protein CE290 PsiE PF06146.12 CAV19187.1 - 5.5e-08 33.1 0.0 6.5e-08 32.8 0.0 1.0 1 0 0 1 1 1 1 Phosphate-starvation-inducible E LPD16 PF18830.1 CAV19187.1 - 0.09 12.7 0.0 0.12 12.3 0.0 1.3 1 0 0 1 1 1 0 Large polyvalent protein-associated domain 16 NAD_binding_10 PF13460.6 CAV19188.1 - 7.4e-11 42.3 0.0 1.1e-10 41.8 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 CAV19188.1 - 4.7e-09 36.1 0.1 6.7e-07 29.0 0.1 2.5 2 1 0 2 2 2 2 NAD dependent epimerase/dehydratase family UDPG_MGDP_dh_N PF03721.14 CAV19188.1 - 0.0021 17.6 0.2 0.0079 15.8 0.1 2.2 2 1 0 2 2 2 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain RmlD_sub_bind PF04321.17 CAV19188.1 - 0.0059 15.7 0.0 0.091 11.8 0.0 2.5 2 1 0 2 2 2 1 RmlD substrate binding domain NAD_binding_2 PF03446.15 CAV19188.1 - 0.019 15.1 0.0 0.045 13.9 0.0 1.7 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase Sacchrp_dh_NADP PF03435.18 CAV19188.1 - 0.053 13.8 0.0 0.16 12.2 0.0 1.9 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain Rossmann-like PF10727.9 CAV19188.1 - 0.1 12.5 0.0 0.22 11.4 0.0 1.5 1 0 0 1 1 1 0 Rossmann-like domain DUF218 PF02698.17 CAV19189.1 - 1.7e-24 86.3 0.0 2.1e-24 86.0 0.0 1.1 1 0 0 1 1 1 1 DUF218 domain TK PF00265.18 CAV19190.1 - 6.4e-59 198.8 0.2 7.2e-59 198.6 0.2 1.0 1 0 0 1 1 1 1 Thymidine kinase AAA_22 PF13401.6 CAV19190.1 - 0.0086 16.4 0.0 0.013 15.8 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_14 PF13173.6 CAV19190.1 - 0.02 14.9 0.0 0.032 14.3 0.0 1.3 1 0 0 1 1 1 0 AAA domain ATPase_2 PF01637.18 CAV19190.1 - 0.047 13.6 0.3 1.2 9.0 0.3 2.1 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea tRNA-synt_1e PF01406.19 CAV19191.1 - 4.5e-142 472.8 0.0 5.7e-142 472.5 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain DALR_2 PF09190.11 CAV19191.1 - 1.3e-24 86.4 0.6 3.8e-24 85.0 0.1 2.0 2 0 0 2 2 2 1 DALR domain tRNA-synt_1g PF09334.11 CAV19191.1 - 6.2e-15 54.8 0.3 3.1e-07 29.5 0.1 2.1 2 0 0 2 2 2 2 tRNA synthetases class I (M) tRNA-synt_1f PF01921.18 CAV19191.1 - 1.5e-06 27.4 0.0 0.00033 19.7 0.0 2.2 2 0 0 2 2 2 2 tRNA synthetases class I (K) tRNA-synt_1 PF00133.22 CAV19191.1 - 5.1e-06 25.0 0.0 1.6e-05 23.4 0.0 1.7 2 0 0 2 2 2 1 tRNA synthetases class I (I, L, M and V) RseA_N PF03872.13 CAV19191.1 - 0.15 12.6 0.4 22 5.6 0.1 2.5 2 0 0 2 2 2 0 Anti sigma-E protein RseA, N-terminal domain Pro_isomerase PF00160.21 CAV19192.1 - 2.1e-46 158.1 0.3 2.3e-46 157.9 0.3 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Metallophos PF00149.28 CAV19193.1 - 1.2e-10 42.2 0.8 2.6e-10 41.2 0.8 1.6 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 CAV19193.1 - 3.8e-10 40.2 0.5 3.9e-09 36.9 0.5 2.0 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain EAL PF00563.20 CAV19194.1 - 8.1e-16 58.3 0.0 4.2e-15 55.9 0.0 2.1 1 1 0 1 1 1 1 EAL domain HDOD PF08668.12 CAV19194.1 - 6e-13 48.7 0.0 1.3e-12 47.6 0.0 1.5 1 0 0 1 1 1 1 HDOD domain UPF0225 PF17775.1 CAV19195.1 - 8.6e-31 106.7 0.0 1.2e-30 106.3 0.0 1.2 1 0 0 1 1 1 1 UPF0225 domain SEC-C PF02810.15 CAV19195.1 - 1.7e-14 53.4 24.1 4.6e-10 39.2 10.6 2.3 2 0 0 2 2 2 2 SEC-C motif PRA-CH PF01502.18 CAV19196.1 - 4.6e-31 106.5 0.0 7.8e-31 105.7 0.0 1.4 1 0 0 1 1 1 1 Phosphoribosyl-AMP cyclohydrolase PRA-PH PF01503.17 CAV19196.1 - 7.8e-19 67.9 0.1 1.1e-18 67.4 0.1 1.2 1 0 0 1 1 1 1 Phosphoribosyl-ATP pyrophosphohydrolase MazG PF03819.17 CAV19196.1 - 0.0013 18.9 0.1 0.0023 18.1 0.1 1.4 1 0 0 1 1 1 1 MazG nucleotide pyrophosphohydrolase domain His_biosynth PF00977.21 CAV19197.1 - 3.4e-78 262.2 1.8 3.9e-78 262.1 1.8 1.0 1 0 0 1 1 1 1 Histidine biosynthesis protein Dus PF01207.17 CAV19197.1 - 2.4e-08 33.4 0.9 1.8e-05 24.0 0.0 2.1 2 0 0 2 2 2 2 Dihydrouridine synthase (Dus) ThiG PF05690.14 CAV19197.1 - 5.3e-07 29.2 0.1 2.3e-05 23.9 0.0 2.1 2 0 0 2 2 2 1 Thiazole biosynthesis protein ThiG NMO PF03060.15 CAV19197.1 - 8e-06 25.5 0.2 0.0037 16.7 0.0 2.2 2 0 0 2 2 2 2 Nitronate monooxygenase TMP-TENI PF02581.17 CAV19197.1 - 0.00045 19.6 0.1 0.012 14.9 0.0 2.3 2 0 0 2 2 2 1 Thiamine monophosphate synthase FMN_dh PF01070.18 CAV19197.1 - 0.0084 15.2 0.3 1 8.3 0.1 2.1 1 1 0 2 2 2 2 FMN-dependent dehydrogenase G3P_antiterm PF04309.12 CAV19197.1 - 0.017 14.5 0.1 0.14 11.6 0.0 2.2 2 1 0 2 2 2 0 Glycerol-3-phosphate responsive antiterminator DHO_dh PF01180.21 CAV19197.1 - 0.019 14.2 0.0 0.05 12.8 0.0 1.6 2 0 0 2 2 2 0 Dihydroorotate dehydrogenase PcrB PF01884.17 CAV19197.1 - 0.055 12.9 0.0 0.15 11.5 0.0 1.7 2 0 0 2 2 2 0 PcrB family Oxidored_FMN PF00724.20 CAV19197.1 - 0.069 12.4 0.1 0.74 9.0 0.0 2.1 2 0 0 2 2 2 0 NADH:flavin oxidoreductase / NADH oxidase family His_biosynth PF00977.21 CAV19198.1 - 3e-75 252.6 1.7 3.4e-75 252.4 1.7 1.0 1 0 0 1 1 1 1 Histidine biosynthesis protein Trp_syntA PF00290.20 CAV19198.1 - 1.1e-05 24.4 0.2 0.00042 19.2 0.0 2.1 2 0 0 2 2 2 1 Tryptophan synthase alpha chain IGPS PF00218.21 CAV19198.1 - 0.00011 21.5 0.1 0.11 11.6 0.0 2.5 3 0 0 3 3 3 2 Indole-3-glycerol phosphate synthase Dus PF01207.17 CAV19198.1 - 0.0003 20.0 0.1 0.36 9.9 0.0 2.1 2 0 0 2 2 2 2 Dihydrouridine synthase (Dus) FMN_dh PF01070.18 CAV19198.1 - 0.005 15.9 2.1 0.047 12.7 0.3 2.3 2 1 0 2 2 2 1 FMN-dependent dehydrogenase DHO_dh PF01180.21 CAV19198.1 - 0.046 12.9 0.0 0.089 12.0 0.0 1.4 1 0 0 1 1 1 0 Dihydroorotate dehydrogenase IMPDH PF00478.25 CAV19198.1 - 0.065 12.2 0.3 0.23 10.4 0.0 1.8 2 0 0 2 2 2 0 IMP dehydrogenase / GMP reductase domain Ribul_P_3_epim PF00834.19 CAV19198.1 - 0.48 9.8 1.5 0.69 9.3 0.1 1.9 3 0 0 3 3 3 0 Ribulose-phosphate 3 epimerase family GATase PF00117.28 CAV19199.1 - 1e-16 61.3 0.0 1.2e-16 61.0 0.0 1.1 1 0 0 1 1 1 1 Glutamine amidotransferase class-I SNO PF01174.19 CAV19199.1 - 4.3e-07 30.0 0.2 0.00014 21.8 0.1 2.1 2 0 0 2 2 2 2 SNO glutamine amidotransferase family Peptidase_C26 PF07722.13 CAV19199.1 - 1.6e-05 24.7 0.3 0.003 17.4 0.0 2.2 2 0 0 2 2 2 2 Peptidase C26 GATase_3 PF07685.14 CAV19199.1 - 2.4e-05 24.0 0.1 3.7e-05 23.4 0.1 1.2 1 0 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain GATase_5 PF13507.6 CAV19199.1 - 0.093 11.8 0.0 0.26 10.3 0.0 1.7 2 1 0 2 2 2 0 CobB/CobQ-like glutamine amidotransferase domain IGPD PF00475.18 CAV19200.1 - 2.2e-66 222.6 0.9 4.1e-66 221.7 0.9 1.5 1 0 0 1 1 1 1 Imidazoleglycerol-phosphate dehydratase PNK3P PF08645.11 CAV19200.1 - 1.8e-06 27.7 0.0 2.8e-06 27.1 0.0 1.4 1 1 0 1 1 1 1 Polynucleotide kinase 3 phosphatase Hydrolase_like PF13242.6 CAV19200.1 - 1e-05 25.5 0.0 2.9e-05 24.0 0.0 1.8 1 0 0 1 1 1 1 HAD-hyrolase-like HAD PF12710.7 CAV19200.1 - 0.0011 19.4 0.0 0.0049 17.3 0.0 2.2 1 1 1 2 2 2 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 CAV19200.1 - 0.0035 17.5 0.0 0.051 13.7 0.0 2.4 2 0 0 2 2 2 1 Haloacid dehalogenase-like hydrolase Aminotran_1_2 PF00155.21 CAV19201.1 - 2.6e-55 188.1 0.0 3e-55 187.9 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.19 CAV19201.1 - 5.7e-06 25.5 0.0 9.4e-06 24.8 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-V Alliinase_C PF04864.13 CAV19201.1 - 0.00059 18.8 0.0 0.00079 18.4 0.0 1.1 1 0 0 1 1 1 1 Allinase Cys_Met_Meta_PP PF01053.20 CAV19201.1 - 0.011 14.3 0.0 0.016 13.8 0.0 1.2 1 0 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme Defensin_beta_2 PF13841.6 CAV19201.1 - 0.25 11.9 1.2 1 9.9 0.1 2.4 3 0 0 3 3 3 0 Beta defensin Defensin_RK-1 PF17860.1 CAV19201.1 - 0.43 11.1 1.3 13 6.3 0.2 2.3 2 0 0 2 2 2 0 RK-1-like defensin Histidinol_dh PF00815.20 CAV19202.1 - 6.6e-168 558.9 2.5 7.5e-168 558.8 2.5 1.0 1 0 0 1 1 1 1 Histidinol dehydrogenase HisG PF01634.18 CAV19203.1 - 7e-45 152.9 0.0 1e-44 152.3 0.0 1.2 1 0 0 1 1 1 1 ATP phosphoribosyltransferase HisG_C PF08029.11 CAV19203.1 - 1e-24 86.5 0.1 2.7e-24 85.1 0.0 1.8 2 0 0 2 2 2 1 HisG, C-terminal domain NMT1 PF09084.11 CAV19203.1 - 0.00086 19.3 0.0 0.002 18.1 0.0 1.6 2 0 0 2 2 2 1 NMT1/THI5 like Na_H_antiporter PF03553.14 CAV19204.1 - 9.4e-103 343.6 21.8 9.4e-103 343.6 21.8 2.1 2 0 0 2 2 2 1 Na+/H+ antiporter family Histone_HNS PF00816.21 CAV19205.1 - 8.2e-20 71.4 7.5 8.2e-20 71.4 7.5 1.4 1 1 0 1 1 1 1 H-NS histone family DUF1018 PF06252.12 CAV19205.1 - 0.15 13.1 4.2 0.29 12.1 3.0 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF1018) PfkB PF00294.24 CAV19206.1 - 3.8e-16 59.3 0.0 3.9e-12 46.1 0.0 2.2 2 0 0 2 2 2 2 pfkB family carbohydrate kinase tRNA_Me_trans PF03054.16 CAV19208.1 - 3.9e-139 463.4 0.0 4.5e-139 463.2 0.0 1.0 1 0 0 1 1 1 1 tRNA methyl transferase NAD_synthase PF02540.17 CAV19208.1 - 1.2e-08 34.4 0.0 4.3e-08 32.6 0.0 1.9 2 0 0 2 2 2 1 NAD synthase ThiI PF02568.14 CAV19208.1 - 1.1e-06 28.4 0.0 1.6e-06 27.9 0.0 1.2 1 0 0 1 1 1 1 Thiamine biosynthesis protein (ThiI) QueC PF06508.13 CAV19208.1 - 0.00023 20.8 0.0 0.0006 19.4 0.0 1.6 2 0 0 2 2 2 1 Queuosine biosynthesis protein QueC Asn_synthase PF00733.21 CAV19208.1 - 0.00064 19.5 0.0 0.00074 19.3 0.0 1.1 1 0 0 1 1 1 1 Asparagine synthase ATP_bind_3 PF01171.20 CAV19208.1 - 0.11 12.2 0.0 0.25 11.1 0.0 1.6 1 0 0 1 1 1 0 PP-loop family DUF489 PF04356.12 CAV19209.1 - 9.7e-76 254.1 0.0 1.1e-75 253.9 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF489) Lyase_1 PF00206.20 CAV19210.1 - 4.7e-73 246.3 0.0 6.1e-73 245.9 0.0 1.1 1 0 0 1 1 1 1 Lyase ASL_C PF08328.11 CAV19210.1 - 1e-51 173.8 0.0 3.6e-51 172.1 0.0 2.0 2 0 0 2 2 2 1 Adenylosuccinate lyase C-terminal Peptidase_M48 PF01435.18 CAV19211.1 - 1.3e-39 136.0 0.9 1.9e-39 135.5 0.9 1.3 1 0 0 1 1 1 1 Peptidase family M48 Peptidase_M56 PF05569.11 CAV19211.1 - 0.00014 21.2 0.0 0.00025 20.3 0.0 1.5 1 0 0 1 1 1 1 BlaR1 peptidase M56 Peptidase_M1 PF01433.20 CAV19211.1 - 0.014 15.0 0.1 0.019 14.5 0.1 1.2 1 0 0 1 1 1 0 Peptidase family M1 domain SprT-like PF10263.9 CAV19211.1 - 0.02 14.7 0.0 0.032 14.1 0.0 1.3 1 0 0 1 1 1 0 SprT-like family Myc_target_1 PF15179.6 CAV19211.1 - 0.042 13.8 0.0 0.085 12.8 0.0 1.5 1 0 0 1 1 1 0 Myc target protein 1 DUF1294 PF06961.13 CAV19211.1 - 0.64 10.3 2.3 1.9 8.8 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1294) MTABC_N PF16185.5 CAV19211.1 - 3.8 6.9 5.4 2.7 7.4 1.5 2.0 2 0 0 2 2 2 0 Mitochondrial ABC-transporter N-terminal five TM region AAA_26 PF13500.6 CAV19213.1 - 4.6e-37 127.8 0.0 5.1e-37 127.6 0.0 1.0 1 0 0 1 1 1 1 AAA domain CbiA PF01656.23 CAV19213.1 - 1.2e-10 41.5 0.0 1.7e-10 41.1 0.0 1.1 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain DUF1611 PF07755.11 CAV19213.1 - 0.0023 17.3 0.2 0.12 11.7 0.0 2.6 2 1 1 3 3 3 1 Domain of unknown function (DUF1611_C) P-loop domain Methyltransf_11 PF08241.12 CAV19214.1 - 4e-26 91.5 0.0 8.2e-26 90.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CAV19214.1 - 2.8e-22 79.2 0.1 7.1e-22 77.9 0.1 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CAV19214.1 - 2.7e-17 63.1 0.0 3.6e-17 62.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CAV19214.1 - 5.4e-17 62.0 0.0 7.7e-17 61.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 CAV19214.1 - 3.5e-16 59.3 0.0 5.2e-16 58.7 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_12 PF08242.12 CAV19214.1 - 4.2e-12 46.7 0.0 8.9e-12 45.6 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain MetW PF07021.12 CAV19214.1 - 2.4e-06 27.3 0.0 4.3e-06 26.4 0.0 1.4 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW Methyltransf_8 PF05148.15 CAV19214.1 - 1.1e-05 25.4 0.0 2.2e-05 24.4 0.0 1.5 1 1 0 1 1 1 1 Hypothetical methyltransferase MTS PF05175.14 CAV19214.1 - 4.2e-05 23.2 0.1 0.00011 21.8 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase small domain Methyltransf_9 PF08003.11 CAV19214.1 - 8e-05 21.7 0.0 0.00012 21.1 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) CMAS PF02353.20 CAV19214.1 - 0.00046 19.6 0.0 0.00063 19.1 0.0 1.3 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase NodS PF05401.11 CAV19214.1 - 0.00051 19.7 0.0 0.00068 19.3 0.0 1.2 1 0 0 1 1 1 1 Nodulation protein S (NodS) FtsJ PF01728.19 CAV19214.1 - 0.00059 20.0 0.0 0.0011 19.1 0.0 1.6 1 1 0 1 1 1 1 FtsJ-like methyltransferase TehB PF03848.14 CAV19214.1 - 0.00059 19.3 0.0 0.00091 18.7 0.0 1.2 1 0 0 1 1 1 1 Tellurite resistance protein TehB DREV PF05219.12 CAV19214.1 - 0.00086 18.5 0.0 0.0012 18.0 0.0 1.2 1 0 0 1 1 1 1 DREV methyltransferase Methyltransf_29 PF03141.16 CAV19214.1 - 0.0029 16.2 0.0 0.0032 16.1 0.0 1.1 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase Methyltransf_32 PF13679.6 CAV19214.1 - 0.0074 16.3 0.1 0.016 15.2 0.1 1.6 1 1 0 1 1 1 1 Methyltransferase domain TPMT PF05724.11 CAV19214.1 - 0.035 13.7 0.0 0.058 13.1 0.0 1.4 1 0 0 1 1 1 0 Thiopurine S-methyltransferase (TPMT) PrmA PF06325.13 CAV19214.1 - 0.038 13.4 0.0 0.053 12.9 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) PCMT PF01135.19 CAV19214.1 - 0.042 13.6 0.0 0.071 12.8 0.0 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_18 PF12847.7 CAV19214.1 - 0.051 13.5 0.0 0.093 12.7 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain SNase PF00565.17 CAV19214.1 - 0.076 13.5 0.0 0.13 12.8 0.0 1.3 1 0 0 1 1 1 0 Staphylococcal nuclease homologue RrnaAD PF00398.20 CAV19214.1 - 0.084 11.9 0.0 0.12 11.4 0.0 1.2 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase Aminotran_1_2 PF00155.21 CAV19215.1 - 2e-50 172.0 0.0 2.3e-50 171.8 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.19 CAV19215.1 - 0.00031 19.8 0.0 0.00046 19.3 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class-V Aminotran_3 PF00202.21 CAV19215.1 - 0.002 16.9 0.0 0.0037 16.0 0.0 1.4 1 0 0 1 1 1 1 Aminotransferase class-III Beta_elim_lyase PF01212.21 CAV19215.1 - 0.0038 16.6 0.0 0.0072 15.6 0.0 1.4 1 1 0 1 1 1 1 Beta-eliminating lyase Cys_Met_Meta_PP PF01053.20 CAV19215.1 - 0.012 14.2 0.0 0.018 13.6 0.0 1.3 1 0 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme DegT_DnrJ_EryC1 PF01041.17 CAV19215.1 - 0.19 11.0 0.4 4.3 6.5 0.0 2.7 3 0 0 3 3 3 0 DegT/DnrJ/EryC1/StrS aminotransferase family BATS PF06968.13 CAV19216.1 - 1.7e-20 73.0 0.1 3.2e-20 72.0 0.1 1.5 1 0 0 1 1 1 1 Biotin and Thiamin Synthesis associated domain Radical_SAM PF04055.21 CAV19216.1 - 2.1e-15 57.5 0.0 4.5e-15 56.4 0.0 1.6 1 0 0 1 1 1 1 Radical SAM superfamily HTH_15 PF12324.8 CAV19216.1 - 0.085 12.8 0.1 0.27 11.2 0.0 1.9 2 0 0 2 2 2 0 Helix-turn-helix domain of alkylmercury lyase Aminotran_3 PF00202.21 CAV19217.1 - 1.4e-130 435.6 0.0 1.7e-130 435.3 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III Beta_elim_lyase PF01212.21 CAV19217.1 - 0.024 13.9 0.0 0.1 11.9 0.0 1.8 2 0 0 2 2 2 0 Beta-eliminating lyase Response_reg PF00072.24 CAV19218.1 - 1.1e-13 51.4 0.0 2.5e-13 50.2 0.0 1.7 1 0 0 1 1 1 1 Response regulator receiver domain TPR_19 PF14559.6 CAV19218.1 - 1e-09 38.7 5.2 0.00053 20.4 0.8 3.8 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_14 PF13428.6 CAV19218.1 - 0.00022 21.8 3.4 11 7.1 0.1 5.9 3 1 4 7 7 7 1 Tetratricopeptide repeat TPR_21 PF09976.9 CAV19218.1 - 0.00095 18.9 4.9 0.044 13.5 0.1 3.4 1 1 1 3 3 3 1 Tetratricopeptide repeat-like domain TPR_8 PF13181.6 CAV19218.1 - 0.0012 18.9 10.8 0.047 13.9 0.1 5.6 6 0 0 6 6 5 1 Tetratricopeptide repeat TPR_2 PF07719.17 CAV19218.1 - 0.0025 17.8 12.2 1.9 8.8 0.1 6.4 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_7 PF13176.6 CAV19218.1 - 0.0037 17.2 3.5 48 4.3 0.0 5.2 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_6 PF13174.6 CAV19218.1 - 0.0067 17.0 4.0 5.3 7.9 0.0 4.4 4 0 0 4 4 3 1 Tetratricopeptide repeat TPR_1 PF00515.28 CAV19218.1 - 0.039 13.8 15.4 1.7 8.6 0.1 6.4 7 0 0 7 7 7 0 Tetratricopeptide repeat TPR_5 PF12688.7 CAV19218.1 - 0.063 13.5 0.8 0.45 10.8 0.1 2.4 2 0 0 2 2 2 0 Tetratrico peptide repeat Cons_hypoth95 PF03602.15 CAV19218.1 - 0.082 12.5 0.1 0.25 10.9 0.0 1.9 2 0 0 2 2 2 0 Conserved hypothetical protein 95 PknG_TPR PF16918.5 CAV19218.1 - 0.13 10.9 0.1 1.2 7.7 0.0 2.1 2 0 0 2 2 2 0 Protein kinase G tetratricopeptide repeat TPR_16 PF13432.6 CAV19218.1 - 0.19 12.4 2.2 17 6.1 0.1 3.4 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_11 PF13414.6 CAV19218.1 - 0.31 10.8 4.4 19 5.0 0.5 4.1 5 0 0 5 5 5 0 TPR repeat TPR_12 PF13424.6 CAV19218.1 - 4.5 7.6 7.3 1.9 8.8 0.3 3.8 4 1 1 5 5 5 0 Tetratricopeptide repeat tRNA-synt_2b PF00587.25 CAV19219.1 - 4.3e-33 114.8 0.0 6.8e-33 114.1 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) Seryl_tRNA_N PF02403.22 CAV19219.1 - 4.5e-30 104.1 3.9 7.8e-30 103.3 3.9 1.4 1 0 0 1 1 1 1 Seryl-tRNA synthetase N-terminal domain DUF4201 PF13870.6 CAV19219.1 - 0.0097 15.7 1.1 0.016 15.0 1.1 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4201) DUF2203 PF09969.9 CAV19219.1 - 0.049 14.3 1.9 0.1 13.4 1.2 1.8 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2203) FapA PF03961.13 CAV19219.1 - 0.1 11.2 2.2 0.18 10.4 2.2 1.3 1 0 0 1 1 1 0 Flagellar Assembly Protein A Thump_like PF18096.1 CAV19219.1 - 0.1 12.6 0.1 0.22 11.5 0.1 1.6 1 0 0 1 1 1 0 THUMP domain-like PCRF PF03462.18 CAV19219.1 - 0.2 11.5 2.5 0.45 10.3 2.3 1.7 2 0 0 2 2 2 0 PCRF domain YscO-like PF16789.5 CAV19219.1 - 0.36 10.9 6.2 0.59 10.1 5.0 1.9 1 1 0 1 1 1 0 YscO-like protein Spc7 PF08317.11 CAV19219.1 - 0.51 9.2 3.4 0.83 8.5 3.4 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein MgsA_C PF12002.8 CAV19220.1 - 2.9e-67 225.8 0.3 5.1e-67 225.0 0.3 1.4 1 0 0 1 1 1 1 MgsA AAA+ ATPase C terminal AAA_assoc_2 PF16193.5 CAV19220.1 - 1e-20 73.8 0.2 2.8e-20 72.4 0.2 1.7 1 0 0 1 1 1 1 AAA C-terminal domain AAA PF00004.29 CAV19220.1 - 6.2e-17 62.3 0.0 1.2e-16 61.4 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 CAV19220.1 - 2.2e-13 50.3 0.0 4.3e-13 49.3 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_5 PF07728.14 CAV19220.1 - 6.3e-07 29.5 0.0 8e-06 25.9 0.0 2.3 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.21 CAV19220.1 - 8.6e-07 28.5 0.2 0.0018 17.7 0.1 2.4 1 1 1 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_16 PF13191.6 CAV19220.1 - 3e-06 27.7 0.6 0.0029 18.0 0.0 3.2 1 1 2 3 3 3 1 AAA ATPase domain Sigma54_activat PF00158.26 CAV19220.1 - 3.7e-05 23.5 0.0 0.013 15.2 0.0 2.2 2 0 0 2 2 2 1 Sigma-54 interaction domain AAA_30 PF13604.6 CAV19220.1 - 4.3e-05 23.3 0.3 0.0023 17.7 0.3 2.3 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.6 CAV19220.1 - 0.00017 21.9 0.1 0.011 16.1 0.1 2.6 1 1 0 1 1 1 1 AAA domain AAA_3 PF07726.11 CAV19220.1 - 0.00041 20.2 0.0 0.0012 18.7 0.0 1.7 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_19 PF13245.6 CAV19220.1 - 0.00041 20.7 0.1 0.17 12.2 0.1 2.3 1 1 1 2 2 2 1 AAA domain AAA_14 PF13173.6 CAV19220.1 - 0.00068 19.7 0.0 0.0013 18.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_2 PF07724.14 CAV19220.1 - 0.0012 18.9 0.0 0.0021 18.2 0.0 1.4 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) ResIII PF04851.15 CAV19220.1 - 0.0023 17.9 0.2 0.66 10.0 0.1 2.3 1 1 1 2 2 2 1 Type III restriction enzyme, res subunit IstB_IS21 PF01695.17 CAV19220.1 - 0.0041 16.9 0.0 0.0087 15.8 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein DNA_pol3_delta2 PF13177.6 CAV19220.1 - 0.0063 16.3 0.0 0.36 10.6 0.0 2.1 1 1 1 2 2 2 1 DNA polymerase III, delta subunit AAA_24 PF13479.6 CAV19220.1 - 0.0064 16.2 0.0 0.013 15.2 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 CAV19220.1 - 0.011 15.5 0.0 0.021 14.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain DUF815 PF05673.13 CAV19220.1 - 0.013 14.7 0.0 0.02 14.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_18 PF13238.6 CAV19220.1 - 0.025 15.1 0.0 0.056 14.0 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 CAV19220.1 - 0.029 14.5 0.0 0.052 13.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain Sigma54_activ_2 PF14532.6 CAV19220.1 - 0.036 14.2 0.0 0.061 13.4 0.0 1.3 1 0 0 1 1 1 0 Sigma-54 interaction domain T2SSE PF00437.20 CAV19220.1 - 0.039 13.0 0.0 0.12 11.4 0.0 1.7 2 0 0 2 2 2 0 Type II/IV secretion system protein AAA_25 PF13481.6 CAV19220.1 - 0.047 13.3 0.0 0.12 12.0 0.0 1.7 1 0 0 1 1 1 0 AAA domain ATPase_2 PF01637.18 CAV19220.1 - 0.091 12.7 0.1 11 5.8 0.0 2.3 1 1 1 2 2 2 0 ATPase domain predominantly from Archaea MMR_HSR1 PF01926.23 CAV19220.1 - 0.16 12.1 0.0 0.26 11.4 0.0 1.4 1 0 0 1 1 1 0 50S ribosome-binding GTPase LolA PF03548.15 CAV19221.1 - 1.1e-54 184.6 1.9 1.2e-54 184.4 1.9 1.0 1 0 0 1 1 1 1 Outer membrane lipoprotein carrier protein LolA V-set PF07686.17 CAV19221.1 - 0.015 15.5 0.4 0.025 14.7 0.4 1.4 1 0 0 1 1 1 0 Immunoglobulin V-set domain GPI-anchored PF10342.9 CAV19221.1 - 0.07 13.9 1.8 0.17 12.7 1.5 1.8 1 1 0 1 1 1 0 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family FtsK_SpoIIIE PF01580.18 CAV19222.1 - 4.2e-69 232.6 0.0 7.9e-69 231.7 0.0 1.5 1 0 0 1 1 1 1 FtsK/SpoIIIE family FtsK_4TM PF13491.6 CAV19222.1 - 4.6e-42 143.6 15.2 6.4e-42 143.2 15.2 1.2 1 0 0 1 1 1 1 4TM region of DNA translocase FtsK/SpoIIIE FtsK_alpha PF17854.1 CAV19222.1 - 1.6e-27 95.6 0.0 3.6e-27 94.5 0.0 1.7 1 0 0 1 1 1 1 FtsK alpha domain FtsK_gamma PF09397.10 CAV19222.1 - 9e-26 89.5 0.0 1.9e-25 88.4 0.0 1.6 1 0 0 1 1 1 1 Ftsk gamma domain AAA_10 PF12846.7 CAV19222.1 - 1.1e-06 27.9 0.0 0.001 18.1 0.0 2.7 3 0 0 3 3 3 2 AAA-like domain DUF87 PF01935.17 CAV19222.1 - 0.00015 22.0 0.1 0.0004 20.5 0.1 1.7 1 0 0 1 1 1 1 Helicase HerA, central domain Cupin_4 PF08007.12 CAV19222.1 - 0.01 15.3 1.1 0.029 13.8 0.0 2.2 2 0 0 2 2 2 0 Cupin superfamily protein T2SSE PF00437.20 CAV19222.1 - 0.017 14.2 0.0 0.034 13.2 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein DEAD PF00270.29 CAV19222.1 - 0.039 13.7 0.0 0.1 12.4 0.0 1.7 1 1 0 1 1 1 0 DEAD/DEAH box helicase TrwB_AAD_bind PF10412.9 CAV19222.1 - 0.048 12.6 0.1 0.32 9.9 0.0 2.0 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain Cupin_3 PF05899.12 CAV19222.1 - 0.17 11.6 0.0 0.36 10.5 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF861) AsnC_trans_reg PF01037.21 CAV19223.1 - 2.3e-23 81.9 0.0 4.3e-23 81.1 0.0 1.4 1 0 0 1 1 1 1 Lrp/AsnC ligand binding domain HTH_24 PF13412.6 CAV19223.1 - 4.5e-22 77.3 0.5 6.7e-22 76.8 0.5 1.3 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding HTH_AsnC-type PF13404.6 CAV19223.1 - 5.6e-20 70.9 0.4 8.4e-20 70.3 0.4 1.3 1 0 0 1 1 1 1 AsnC-type helix-turn-helix domain MarR_2 PF12802.7 CAV19223.1 - 0.0086 15.9 0.0 0.015 15.2 0.0 1.3 1 0 0 1 1 1 1 MarR family MarR PF01047.22 CAV19223.1 - 0.01 15.8 0.0 0.019 14.9 0.0 1.4 1 0 0 1 1 1 0 MarR family Fe_dep_repress PF01325.19 CAV19223.1 - 0.014 15.6 0.0 0.027 14.7 0.0 1.4 1 0 0 1 1 1 0 Iron dependent repressor, N-terminal DNA binding domain HTH_Crp_2 PF13545.6 CAV19223.1 - 0.023 14.7 0.0 0.072 13.1 0.0 1.8 1 1 0 1 1 1 0 Crp-like helix-turn-helix domain E3_UFM1_ligase PF09743.9 CAV19223.1 - 0.033 13.8 0.0 0.044 13.4 0.0 1.2 1 0 0 1 1 1 0 E3 UFM1-protein ligase 1 LexA_DNA_bind PF01726.16 CAV19223.1 - 0.035 13.9 0.0 0.06 13.1 0.0 1.4 1 0 0 1 1 1 0 LexA DNA binding domain HTH_27 PF13463.6 CAV19223.1 - 0.1 13.1 0.0 0.16 12.5 0.0 1.3 1 0 0 1 1 1 0 Winged helix DNA-binding domain HTH_20 PF12840.7 CAV19223.1 - 0.11 12.6 0.0 0.17 11.9 0.0 1.3 1 0 0 1 1 1 0 Helix-turn-helix domain AlaDh_PNT_C PF01262.21 CAV19224.1 - 1.6e-83 279.2 3.6 2.3e-83 278.7 3.6 1.2 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain AlaDh_PNT_N PF05222.15 CAV19224.1 - 1.8e-46 157.8 0.0 3.2e-46 157.0 0.0 1.4 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, N-terminal domain Shikimate_DH PF01488.20 CAV19224.1 - 5.1e-07 29.8 0.0 9.4e-07 29.0 0.0 1.4 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase Pyr_redox_2 PF07992.14 CAV19224.1 - 4.9e-06 26.0 0.2 8.5e-06 25.2 0.2 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 CAV19224.1 - 6.4e-06 26.6 0.7 1.3e-05 25.6 0.7 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase 2-Hacid_dh_C PF02826.19 CAV19224.1 - 7.5e-06 25.4 0.1 1.6e-05 24.3 0.1 1.5 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_binding_7 PF13241.6 CAV19224.1 - 7.4e-05 23.1 0.5 0.00019 21.8 0.5 1.6 1 0 0 1 1 1 1 Putative NAD(P)-binding NAD_binding_2 PF03446.15 CAV19224.1 - 0.00015 22.0 1.5 0.0026 18.0 0.6 2.3 2 0 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase DAO PF01266.24 CAV19224.1 - 0.0031 17.2 2.8 0.0096 15.5 2.7 1.8 1 1 1 2 2 2 1 FAD dependent oxidoreductase 3HCDH_N PF02737.18 CAV19224.1 - 0.0042 17.0 1.1 0.012 15.5 1.0 1.8 1 1 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain TrkA_N PF02254.18 CAV19224.1 - 0.0099 16.1 3.6 0.018 15.3 1.1 2.5 3 0 0 3 3 2 1 TrkA-N domain THF_DHG_CYH_C PF02882.19 CAV19224.1 - 0.015 14.7 7.5 0.15 11.4 4.4 3.3 3 1 0 3 3 3 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain XdhC_C PF13478.6 CAV19224.1 - 0.043 14.3 0.2 0.097 13.2 0.2 1.6 1 0 0 1 1 1 0 XdhC Rossmann domain GIDA PF01134.22 CAV19224.1 - 0.085 11.9 0.1 0.13 11.3 0.1 1.3 1 0 0 1 1 1 0 Glucose inhibited division protein A NAD_binding_8 PF13450.6 CAV19224.1 - 0.11 12.8 0.2 0.39 11.0 0.1 2.0 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.14 CAV19224.1 - 0.12 11.1 0.1 0.17 10.6 0.1 1.2 1 0 0 1 1 1 0 HI0933-like protein Sacchrp_dh_NADP PF03435.18 CAV19224.1 - 0.32 11.2 3.8 1.3 9.3 2.7 2.5 2 1 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain Methyltransf_32 PF13679.6 CAV19225.1 - 5.4e-17 62.2 0.8 1.1e-16 61.2 0.8 1.5 1 1 0 1 1 1 1 Methyltransferase domain TRM13 PF05206.14 CAV19225.1 - 0.00083 18.9 1.6 0.78 9.2 0.0 3.0 2 1 0 2 2 2 2 Methyltransferase TRM13 RrnaAD PF00398.20 CAV19225.1 - 0.0035 16.4 0.0 0.0053 15.9 0.0 1.2 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Methyltransf_25 PF13649.6 CAV19225.1 - 0.0084 16.8 0.1 0.021 15.5 0.1 1.7 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 CAV19225.1 - 0.045 13.3 0.0 0.074 12.6 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain LysR_substrate PF03466.20 CAV19226.1 - 1.2e-37 129.3 0.0 1.7e-37 128.8 0.0 1.2 1 0 0 1 1 1 1 LysR substrate binding domain HTH_1 PF00126.27 CAV19226.1 - 3.2e-16 59.0 0.6 1.4e-15 57.0 0.1 2.2 2 0 0 2 2 2 1 Bacterial regulatory helix-turn-helix protein, lysR family HTH_30 PF13556.6 CAV19226.1 - 0.0083 15.9 0.0 0.019 14.8 0.0 1.6 1 0 0 1 1 1 1 PucR C-terminal helix-turn-helix domain ZapB PF06005.12 CAV19227.1 - 0.014 15.8 10.3 0.094 13.2 0.5 2.8 2 1 0 2 2 2 0 Cell division protein ZapB DUF2096 PF09869.9 CAV19227.1 - 0.02 15.0 1.5 0.02 15.0 1.5 1.9 2 1 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2096) Alkyl_sulf_dimr PF14863.6 CAV19227.1 - 0.034 14.6 1.6 1.6 9.1 0.4 2.3 2 0 0 2 2 2 0 Alkyl sulfatase dimerisation UPF0242 PF06785.11 CAV19227.1 - 0.041 14.0 8.5 2.4 8.2 8.5 2.2 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus CDT1_C PF16679.5 CAV19227.1 - 0.046 14.2 1.2 0.25 11.8 0.0 2.6 1 1 1 2 2 2 0 DNA replication factor Cdt1 C-terminal domain HCMV_UL139 PF12507.8 CAV19227.1 - 0.046 14.1 2.3 2 8.8 0.2 2.6 2 1 0 2 2 2 0 Human Cytomegalovirus UL139 protein Con-6 PF10346.9 CAV19227.1 - 0.055 13.5 0.6 0.13 12.4 0.0 2.0 2 0 0 2 2 2 0 Conidiation protein 6 CorA PF01544.18 CAV19227.1 - 0.12 11.7 4.4 0.5 9.6 3.9 2.0 1 1 1 2 2 2 0 CorA-like Mg2+ transporter protein WXG100 PF06013.12 CAV19227.1 - 0.14 12.4 4.5 0.62 10.3 0.1 2.6 2 1 0 2 2 2 0 Proteins of 100 residues with WXG Pet100 PF09803.9 CAV19227.1 - 0.26 11.8 1.2 21 5.8 0.4 2.6 2 0 0 2 2 2 0 Pet100 PspB PF06667.12 CAV19227.1 - 4.2 7.5 10.1 22 5.2 0.1 3.3 3 0 0 3 3 3 0 Phage shock protein B MiaE PF06175.11 CAV19228.1 - 1.3e-105 352.3 2.9 1.6e-105 352.0 2.9 1.0 1 0 0 1 1 1 1 tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE) OMPdecase PF00215.24 CAV19229.1 - 1.4e-50 172.0 0.0 1.5e-50 171.9 0.0 1.0 1 0 0 1 1 1 1 Orotidine 5'-phosphate decarboxylase / HUMPS family TPR_14 PF13428.6 CAV19230.1 - 5.4e-13 48.6 3.0 0.49 11.4 0.0 7.1 3 3 4 7 7 7 4 Tetratricopeptide repeat Rubredoxin_2 PF18073.1 CAV19230.1 - 8.7e-13 47.8 8.4 1.4e-12 47.1 8.4 1.4 1 0 0 1 1 1 1 Rubredoxin metal binding domain TPR_19 PF14559.6 CAV19230.1 - 4.6e-12 46.3 5.7 0.00017 22.0 0.0 5.3 3 1 1 5 5 5 4 Tetratricopeptide repeat TPR_12 PF13424.6 CAV19230.1 - 5e-11 42.7 3.1 0.065 13.5 0.1 5.1 2 1 3 5 5 5 4 Tetratricopeptide repeat TPR_2 PF07719.17 CAV19230.1 - 1e-10 40.9 4.0 0.0017 18.3 0.1 7.0 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_1 PF00515.28 CAV19230.1 - 4.9e-10 38.8 1.7 0.0053 16.5 0.1 6.0 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_7 PF13176.6 CAV19230.1 - 2.3e-09 36.6 9.3 0.02 14.9 0.0 6.8 6 1 1 7 7 7 1 Tetratricopeptide repeat TPR_20 PF14561.6 CAV19230.1 - 1.8e-08 34.6 3.3 0.27 11.6 0.0 4.5 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_8 PF13181.6 CAV19230.1 - 3.8e-06 26.7 0.8 6.7 7.2 0.1 5.6 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_11 PF13414.6 CAV19230.1 - 9.7e-06 25.2 0.0 0.61 9.8 0.0 3.8 3 1 1 4 4 4 2 TPR repeat TPR_16 PF13432.6 CAV19230.1 - 1.9e-05 25.2 0.1 0.17 12.6 0.0 4.2 4 0 0 4 4 4 1 Tetratricopeptide repeat ANAPC3 PF12895.7 CAV19230.1 - 3.5e-05 23.9 3.1 0.094 12.9 0.8 4.4 1 1 2 4 4 4 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.6 CAV19230.1 - 8.5e-05 22.9 6.6 67 4.4 0.1 7.0 9 0 0 9 9 6 0 Tetratricopeptide repeat DUF2989 PF11207.8 CAV19230.1 - 0.00051 19.9 2.9 0.47 10.2 0.2 2.7 2 1 1 3 3 3 2 Protein of unknown function (DUF2989) TPR_10 PF13374.6 CAV19230.1 - 0.001 18.9 2.8 30 4.7 0.0 5.3 6 0 0 6 6 5 0 Tetratricopeptide repeat TPR_17 PF13431.6 CAV19230.1 - 0.0063 16.8 0.0 34 5.1 0.0 4.2 4 0 0 4 4 4 0 Tetratricopeptide repeat zinc_ribbon_15 PF17032.5 CAV19230.1 - 0.012 16.4 0.2 0.029 15.1 0.2 1.7 1 0 0 1 1 1 0 zinc-ribbon family HypA PF01155.19 CAV19230.1 - 0.029 14.4 0.0 0.088 12.8 0.0 1.8 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA TPR_15 PF13429.6 CAV19230.1 - 0.053 12.7 3.2 0.45 9.7 1.0 2.9 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_5 PF12688.7 CAV19230.1 - 0.055 13.7 0.4 0.64 10.3 0.1 2.5 2 1 0 2 2 2 0 Tetratrico peptide repeat TPR_9 PF13371.6 CAV19230.1 - 0.089 13.0 0.0 8.2 6.7 0.0 3.0 2 1 1 3 3 3 0 Tetratricopeptide repeat SPG48 PF14764.6 CAV19230.1 - 0.098 13.1 0.1 0.51 10.8 0.1 2.2 1 1 1 2 2 2 0 AP-5 complex subunit, vesicle trafficking LapA_dom PF06305.11 CAV19231.1 - 2.5e-17 62.4 1.2 2.5e-17 62.4 1.2 1.7 2 0 0 2 2 2 1 Lipopolysaccharide assembly protein A domain DUF2182 PF09948.9 CAV19231.1 - 0.0068 16.3 0.2 0.01 15.7 0.2 1.4 1 1 0 1 1 1 1 Predicted metal-binding integral membrane protein (DUF2182) Bac_DNA_binding PF00216.21 CAV19232.1 - 9.1e-31 105.9 0.0 1e-30 105.8 0.0 1.0 1 0 0 1 1 1 1 Bacterial DNA-binding protein HU-HIG PF18291.1 CAV19232.1 - 2e-07 31.2 0.0 2.3e-07 31.0 0.0 1.0 1 0 0 1 1 1 1 HU domain fused to wHTH, Ig, or Glycine-rich motif HU-CCDC81_bac_2 PF18175.1 CAV19232.1 - 0.00026 20.8 0.0 0.00037 20.3 0.0 1.2 1 0 0 1 1 1 1 CCDC81-like prokaryotic HU domain 2 HU-DNA_bdg PF14848.6 CAV19232.1 - 0.0076 16.3 0.0 0.036 14.1 0.0 1.8 1 1 0 1 1 1 1 DNA-binding domain HU-CCDC81_euk_1 PF14908.6 CAV19232.1 - 0.091 12.9 0.0 0.1 12.8 0.0 1.1 1 0 0 1 1 1 0 CCDC81 eukaryotic HU domain 1 DUF4777 PF16007.5 CAV19232.1 - 0.12 12.6 0.1 0.22 11.8 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4777) Glycos_trans_3N PF02885.17 CAV19232.1 - 0.13 12.2 0.1 0.17 11.7 0.1 1.2 1 0 0 1 1 1 0 Glycosyl transferase family, helical bundle domain Coagulin PF02035.15 CAV19232.1 - 0.21 11.5 0.0 0.22 11.4 0.0 1.1 1 0 0 1 1 1 0 Coagulin S1 PF00575.23 CAV19233.1 - 1.5e-95 313.6 31.8 3.6e-21 75.3 0.3 6.1 6 0 0 6 6 6 6 S1 RNA binding domain PCB_OB PF17092.5 CAV19233.1 - 1.3e-09 38.8 9.5 0.086 13.6 0.1 6.1 2 1 4 6 6 6 3 Penicillin-binding protein OB-like domain S1_2 PF13509.6 CAV19233.1 - 0.00011 22.2 7.1 8.8 6.5 0.3 5.8 4 1 0 4 4 4 3 S1 domain CsrA PF02599.16 CAV19233.1 - 0.12 12.3 8.1 8.5 6.4 0.1 4.4 5 0 0 5 5 5 0 Global regulator protein family RsgI_N PF12791.7 CAV19233.1 - 0.13 12.2 2.5 4.6 7.2 0.0 3.7 3 0 0 3 3 3 0 Anti-sigma factor N-terminus TOBE PF03459.17 CAV19233.1 - 2 8.8 4.7 5.8 7.3 0.9 3.5 2 2 0 2 2 2 0 TOBE domain MoeA_C PF03454.15 CAV19233.1 - 2.7 8.2 8.3 1.2 9.4 0.0 4.3 4 1 0 4 4 4 0 MoeA C-terminal region (domain IV) RuvA_N PF01330.21 CAV19233.1 - 4.8 7.3 6.4 10 6.3 0.1 3.9 4 0 0 4 4 4 0 RuvA N terminal domain Cytidylate_kin PF02224.18 CAV19234.1 - 7.1e-78 261.2 0.1 8e-78 261.0 0.1 1.0 1 0 0 1 1 1 1 Cytidylate kinase AAA_17 PF13207.6 CAV19234.1 - 2.5e-06 28.0 1.6 0.00092 19.6 0.0 2.7 1 1 1 2 2 2 2 AAA domain Cytidylate_kin2 PF13189.6 CAV19234.1 - 2.9e-06 27.5 1.0 1e-05 25.7 1.0 1.9 1 1 0 1 1 1 1 Cytidylate kinase-like family AAA_18 PF13238.6 CAV19234.1 - 3e-05 24.6 0.1 0.00043 20.8 0.1 2.3 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.6 CAV19234.1 - 0.0062 16.7 0.1 0.016 15.4 0.1 1.9 1 1 0 1 1 1 1 AAA domain ADK PF00406.22 CAV19234.1 - 0.007 16.5 0.0 0.018 15.1 0.0 1.7 1 1 0 1 1 1 1 Adenylate kinase dNK PF01712.19 CAV19234.1 - 0.027 14.3 0.1 0.073 12.9 0.0 1.7 2 1 1 3 3 3 0 Deoxynucleoside kinase SKI PF01202.22 CAV19234.1 - 0.028 14.5 0.7 0.55 10.3 0.0 2.4 2 1 0 2 2 2 0 Shikimate kinase ATP_bind_2 PF03668.15 CAV19234.1 - 0.043 13.1 1.2 2.4 7.4 0.0 2.2 1 1 0 2 2 2 0 P-loop ATPase protein family ABC_tran PF00005.27 CAV19234.1 - 0.065 13.7 0.0 0.15 12.6 0.0 1.8 1 1 0 1 1 1 0 ABC transporter APS_kinase PF01583.20 CAV19234.1 - 0.085 12.7 0.3 3.2 7.6 0.0 2.6 2 1 0 2 2 2 0 Adenylylsulphate kinase Tower PF09121.10 CAV19234.1 - 0.12 12.6 0.3 0.26 11.5 0.3 1.6 1 0 0 1 1 1 0 Tower CTP_transf_3 PF02348.19 CAV19235.1 - 5e-64 216.3 0.0 5.8e-64 216.0 0.0 1.0 1 0 0 1 1 1 1 Cytidylyltransferase NTP_transf_3 PF12804.7 CAV19235.1 - 2.3e-11 44.3 0.0 3.3e-11 43.8 0.0 1.3 1 1 0 1 1 1 1 MobA-like NTP transferase domain Trm112p PF03966.16 CAV19236.1 - 1.6e-11 44.6 0.2 2.4e-11 44.0 0.2 1.3 1 0 0 1 1 1 1 Trm112p-like protein TF_Zn_Ribbon PF08271.12 CAV19236.1 - 0.00095 18.6 0.3 0.0018 17.8 0.3 1.4 1 0 0 1 1 1 1 TFIIB zinc-binding Rad50_zn_hook PF04423.14 CAV19236.1 - 0.0066 16.3 0.3 0.0087 15.9 0.3 1.2 1 0 0 1 1 1 1 Rad50 zinc hook motif PADR1 PF08063.12 CAV19236.1 - 0.037 13.8 0.1 0.048 13.4 0.1 1.2 1 0 0 1 1 1 0 PADR1 (NUC008) domain LpxK PF02606.14 CAV19237.1 - 2.2e-108 362.2 0.0 2.7e-108 362.0 0.0 1.0 1 0 0 1 1 1 1 Tetraacyldisaccharide-1-P 4'-kinase ABC_membrane PF00664.23 CAV19238.1 - 8.9e-57 192.8 12.8 1.2e-56 192.3 12.8 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 CAV19238.1 - 2.4e-36 125.3 0.2 6e-36 124.0 0.0 1.8 2 0 0 2 2 1 1 ABC transporter SMC_N PF02463.19 CAV19238.1 - 3.3e-10 39.8 5.0 4.3e-09 36.1 0.6 2.4 1 1 1 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 CAV19238.1 - 3.2e-06 27.6 0.2 6.8e-06 26.6 0.2 1.5 1 0 0 1 1 1 1 AAA ATPase domain AAA_24 PF13479.6 CAV19238.1 - 7.1e-05 22.6 0.0 0.00026 20.8 0.0 2.0 1 1 0 1 1 1 1 AAA domain RsgA_GTPase PF03193.16 CAV19238.1 - 7.4e-05 22.7 0.0 0.0002 21.3 0.0 1.7 1 0 0 1 1 1 1 RsgA GTPase DEAD PF00270.29 CAV19238.1 - 0.00024 20.9 0.0 0.00072 19.4 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 CAV19238.1 - 0.00027 21.2 0.8 0.0018 18.5 0.8 2.4 1 1 0 1 1 1 1 AAA domain Zeta_toxin PF06414.12 CAV19238.1 - 0.00049 19.4 0.0 0.0012 18.2 0.0 1.6 1 0 0 1 1 1 1 Zeta toxin APS_kinase PF01583.20 CAV19238.1 - 0.0011 18.8 0.0 0.0025 17.7 0.0 1.6 1 0 0 1 1 1 1 Adenylylsulphate kinase AAA_29 PF13555.6 CAV19238.1 - 0.0021 17.8 0.1 0.0066 16.2 0.1 1.8 1 0 0 1 1 1 1 P-loop containing region of AAA domain DUF2075 PF09848.9 CAV19238.1 - 0.0027 17.0 0.2 0.0047 16.2 0.2 1.3 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) G-alpha PF00503.20 CAV19238.1 - 0.0032 16.7 0.0 0.01 15.0 0.0 1.8 2 0 0 2 2 2 1 G-protein alpha subunit EMC3_TMCO1 PF01956.16 CAV19238.1 - 0.0042 16.8 2.6 0.0042 16.8 2.6 2.3 2 0 0 2 2 2 1 Integral membrane protein EMC3/TMCO1-like AAA_21 PF13304.6 CAV19238.1 - 0.0056 16.5 1.4 1.5 8.5 0.1 2.2 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_25 PF13481.6 CAV19238.1 - 0.0065 16.1 0.3 0.21 11.1 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_15 PF13175.6 CAV19238.1 - 0.017 14.8 0.0 0.032 14.0 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain SbcCD_C PF13558.6 CAV19238.1 - 0.019 15.2 1.3 7.7 6.8 0.8 3.6 3 1 0 3 3 2 0 Putative exonuclease SbcCD, C subunit AAA_30 PF13604.6 CAV19238.1 - 0.024 14.4 2.5 0.11 12.1 0.9 2.7 2 1 0 2 2 2 0 AAA domain MMR_HSR1 PF01926.23 CAV19238.1 - 0.025 14.7 0.3 0.11 12.6 0.3 2.2 1 1 0 1 1 1 0 50S ribosome-binding GTPase AAA_23 PF13476.6 CAV19238.1 - 0.067 13.7 1.3 0.97 9.9 0.1 2.4 2 0 0 2 2 2 0 AAA domain ATPase PF06745.13 CAV19238.1 - 0.072 12.4 0.3 0.21 10.9 0.0 1.9 2 0 0 2 2 2 0 KaiC ABC_membrane_2 PF06472.15 CAV19238.1 - 0.094 12.1 3.9 0.15 11.4 3.9 1.3 1 0 0 1 1 1 0 ABC transporter transmembrane region 2 IstB_IS21 PF01695.17 CAV19238.1 - 0.11 12.3 1.0 3.1 7.5 0.0 3.3 2 1 0 2 2 2 0 IstB-like ATP binding protein ABC_ATPase PF09818.9 CAV19238.1 - 0.39 9.4 4.3 0.43 9.3 0.1 2.8 3 1 0 3 3 3 0 Predicted ATPase of the ABC class ABC2_membrane_2 PF12679.7 CAV19238.1 - 3.5 6.8 11.5 0.055 12.7 2.4 2.2 2 1 0 2 2 2 0 ABC-2 family transporter protein Competence PF03772.16 CAV19239.1 - 2.4e-50 171.3 36.3 2.4e-50 171.3 36.3 2.2 2 0 0 2 2 2 1 Competence protein Lactamase_B PF00753.27 CAV19239.1 - 1.2e-10 41.8 0.0 2.2e-10 40.9 0.0 1.4 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily DUF4131 PF13567.6 CAV19239.1 - 5.2e-05 22.9 0.4 5.2e-05 22.9 0.4 4.7 3 1 0 3 3 3 1 Domain of unknown function (DUF4131) Lactamase_B_2 PF12706.7 CAV19239.1 - 0.0016 18.0 0.0 0.0025 17.4 0.0 1.2 1 0 0 1 1 1 1 Beta-lactamase superfamily domain DUF2062 PF09835.9 CAV19240.1 - 1.1e-45 155.1 11.1 1.3e-45 154.9 11.1 1.0 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2062) MacB_PCD PF12704.7 CAV19241.1 - 1.4e-13 51.7 3.8 1.4e-13 51.7 3.8 2.8 3 0 0 3 3 3 2 MacB-like periplasmic core domain FtsX PF02687.21 CAV19241.1 - 1.4e-12 47.9 1.2 1.4e-12 47.9 1.2 3.4 3 1 0 3 3 3 1 FtsX-like permease family DUF3318 PF11780.8 CAV19241.1 - 0.0032 17.4 2.2 1 9.3 0.0 3.4 3 0 0 3 3 3 2 Protein of unknown function (DUF3318) ABC_tran PF00005.27 CAV19242.1 - 1.1e-33 116.7 0.0 1.4e-33 116.3 0.0 1.2 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 CAV19242.1 - 2.4e-06 27.6 2.6 0.028 14.2 0.1 2.1 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 CAV19242.1 - 2.6e-06 27.0 0.3 0.0023 17.4 0.0 2.1 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 CAV19242.1 - 9.9e-05 22.0 0.3 0.00019 21.1 0.3 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 CAV19242.1 - 0.0035 17.3 0.1 0.0061 16.5 0.1 1.4 1 0 0 1 1 1 1 RsgA GTPase AAA_28 PF13521.6 CAV19242.1 - 0.0057 16.9 0.0 0.023 14.9 0.0 1.9 2 1 0 2 2 2 1 AAA domain AAA_15 PF13175.6 CAV19242.1 - 0.0081 15.9 0.0 0.011 15.5 0.0 1.3 1 0 0 1 1 1 1 AAA ATPase domain AAA_16 PF13191.6 CAV19242.1 - 0.0089 16.4 0.7 0.014 15.7 0.7 1.4 1 1 0 1 1 1 1 AAA ATPase domain IstB_IS21 PF01695.17 CAV19242.1 - 0.0096 15.7 0.0 0.057 13.1 0.0 2.0 2 0 0 2 2 2 1 IstB-like ATP binding protein AAA_18 PF13238.6 CAV19242.1 - 0.013 16.1 0.0 0.021 15.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 CAV19242.1 - 0.016 15.5 0.0 0.063 13.5 0.0 1.9 2 0 0 2 2 2 0 AAA domain FtsK_SpoIIIE PF01580.18 CAV19242.1 - 0.02 14.2 0.1 0.03 13.7 0.1 1.3 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_25 PF13481.6 CAV19242.1 - 0.028 14.0 0.3 0.4 10.2 0.2 2.1 2 0 0 2 2 2 0 AAA domain NACHT PF05729.12 CAV19242.1 - 0.031 14.2 0.2 0.17 11.8 0.0 2.0 2 1 0 2 2 2 0 NACHT domain AAA_30 PF13604.6 CAV19242.1 - 0.036 13.8 0.1 0.052 13.3 0.1 1.5 1 1 0 1 1 1 0 AAA domain Dioxygenase_N PF04444.14 CAV19242.1 - 0.047 13.5 0.0 0.1 12.5 0.0 1.5 1 0 0 1 1 1 0 Catechol dioxygenase N terminus AAA_23 PF13476.6 CAV19242.1 - 0.052 14.0 0.2 0.094 13.2 0.2 1.3 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 CAV19242.1 - 0.065 13.4 0.1 0.11 12.6 0.1 1.6 1 1 0 1 1 1 0 AAA domain MMR_HSR1 PF01926.23 CAV19242.1 - 0.11 12.6 0.3 0.2 11.8 0.3 1.9 1 1 0 1 1 1 0 50S ribosome-binding GTPase FtsX PF02687.21 CAV19243.1 - 6.5e-13 49.0 8.8 6.5e-13 49.0 8.8 3.0 2 1 1 3 3 3 1 FtsX-like permease family MacB_PCD PF12704.7 CAV19243.1 - 7.5e-13 49.3 0.3 7.5e-13 49.3 0.3 2.3 2 0 0 2 2 2 1 MacB-like periplasmic core domain TRCF PF03461.15 CAV19245.1 - 6.1e-28 97.1 0.3 9.7e-27 93.2 0.0 2.8 3 0 0 3 3 3 1 TRCF domain CarD_CdnL_TRCF PF02559.16 CAV19245.1 - 8.5e-26 90.5 0.2 7.6e-25 87.5 0.0 2.7 3 0 0 3 3 3 1 CarD-like/TRCF domain UvrB_inter PF17757.1 CAV19245.1 - 1.4e-22 79.7 0.0 3.5e-22 78.4 0.0 1.8 1 0 0 1 1 1 1 UvrB interaction domain DEAD PF00270.29 CAV19245.1 - 2.8e-21 76.1 0.6 1.1e-20 74.1 0.3 2.2 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CAV19245.1 - 8.4e-20 71.2 1.4 3.9e-16 59.4 0.3 2.6 2 0 0 2 2 2 2 Helicase conserved C-terminal domain ResIII PF04851.15 CAV19245.1 - 2e-12 47.4 0.1 3.5e-10 40.2 0.0 3.0 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit UB2H PF14814.6 CAV19245.1 - 0.0023 17.9 0.0 0.015 15.4 0.0 2.5 2 0 0 2 2 2 1 Bifunctional transglycosylase second domain ERCC3_RAD25_C PF16203.5 CAV19245.1 - 0.0084 15.3 0.1 0.031 13.5 0.0 1.8 2 0 0 2 2 2 1 ERCC3/RAD25/XPB C-terminal helicase Glyco_tran_WecB PF03808.13 CAV19245.1 - 0.026 14.5 0.1 0.61 10.0 0.0 2.8 3 0 0 3 3 3 0 Glycosyl transferase WecB/TagA/CpsF family LcrG PF07216.12 CAV19245.1 - 0.034 14.1 0.1 4.1 7.4 0.0 2.9 2 0 0 2 2 2 0 LcrG protein AAA_5 PF07728.14 CAV19245.1 - 0.046 13.7 0.9 8.8 6.3 0.0 3.4 4 0 0 4 4 4 0 AAA domain (dynein-related subfamily) CsiV PF10972.8 CAV19246.1 - 7.7e-64 215.8 0.5 1e-63 215.4 0.5 1.1 1 0 0 1 1 1 1 Peptidoglycan-binding protein, CsiV Acetyltransf_3 PF13302.7 CAV19247.1 - 2.4e-21 76.8 0.0 2.8e-21 76.6 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 CAV19247.1 - 6.6e-11 42.5 0.0 8.6e-11 42.1 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_4 PF13420.7 CAV19247.1 - 4.1e-07 30.3 0.0 4.6e-07 30.1 0.0 1.0 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.6 CAV19247.1 - 0.054 13.2 0.0 0.084 12.5 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 CAV19247.1 - 0.076 13.5 0.0 0.11 12.9 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 CAV19247.1 - 0.12 12.3 0.0 0.15 12.0 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Pyr_redox_2 PF07992.14 CAV19248.1 - 1.3e-62 211.7 0.1 1.6e-62 211.5 0.1 1.0 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 CAV19248.1 - 9.1e-15 55.0 1.4 2.7e-08 34.3 0.3 2.8 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 CAV19248.1 - 1.4e-05 25.1 1.4 0.086 12.8 0.1 3.7 3 1 1 4 4 4 2 FAD-NAD(P)-binding DAO PF01266.24 CAV19248.1 - 4.3e-05 23.3 1.9 0.5 9.9 0.0 3.1 3 0 0 3 3 3 2 FAD dependent oxidoreductase Lycopene_cycl PF05834.12 CAV19248.1 - 0.00015 20.9 1.0 0.17 10.9 0.1 2.9 3 0 0 3 3 3 2 Lycopene cyclase protein Pyr_redox_3 PF13738.6 CAV19248.1 - 0.0003 20.1 0.2 0.055 12.7 0.0 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 CAV19248.1 - 0.0012 17.7 0.2 1.2 7.7 0.0 3.4 4 0 0 4 4 4 1 HI0933-like protein SAVED PF18145.1 CAV19248.1 - 0.0021 17.9 0.0 2.4 8.0 0.0 2.9 3 0 0 3 3 3 2 SMODS-associated and fused to various effectors sensor domain NAD_binding_8 PF13450.6 CAV19248.1 - 0.0037 17.5 1.6 0.3 11.3 0.3 2.6 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain K_oxygenase PF13434.6 CAV19248.1 - 0.0038 16.4 0.1 2.2 7.4 0.0 2.3 2 0 0 2 2 2 2 L-lysine 6-monooxygenase (NADPH-requiring) ThiF PF00899.21 CAV19248.1 - 0.0075 15.6 0.8 2 7.7 0.2 2.4 2 0 0 2 2 2 2 ThiF family FAD_binding_3 PF01494.19 CAV19248.1 - 0.0091 15.3 0.2 2.8 7.1 0.1 2.4 2 0 0 2 2 2 2 FAD binding domain ApbA PF02558.16 CAV19248.1 - 0.019 14.6 0.4 3.6 7.2 0.0 2.3 2 0 0 2 2 2 0 Ketopantoate reductase PanE/ApbA GIDA PF01134.22 CAV19248.1 - 0.11 11.6 3.5 6.4 5.8 0.0 3.6 3 1 1 4 4 4 0 Glucose inhibited division protein A Trp_halogenase PF04820.14 CAV19248.1 - 0.93 8.3 2.5 1.1 8.0 0.2 2.1 3 0 0 3 3 3 0 Tryptophan halogenase UPF0227 PF05728.12 CAV19249.1 - 5.7e-67 225.3 0.1 6.4e-67 225.1 0.1 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0227) IML1 PF12257.8 CAV19249.1 - 0.021 14.0 0.3 0.028 13.5 0.3 1.2 1 0 0 1 1 1 0 Vacuolar membrane-associated protein Iml1 Choline_kinase PF01633.20 CAV19250.1 - 6e-11 42.3 0.0 7.7e-06 25.6 0.0 2.1 1 1 0 2 2 2 2 Choline/ethanolamine kinase APH PF01636.23 CAV19250.1 - 4.3e-09 36.7 0.2 1.4e-08 35.0 0.1 1.8 1 1 0 1 1 1 1 Phosphotransferase enzyme family RIO1 PF01163.22 CAV19250.1 - 0.0046 16.6 0.0 0.27 10.8 0.0 2.1 2 0 0 2 2 2 2 RIO1 family LpoB PF13036.6 CAV19252.1 - 7.3e-55 184.9 2.4 8.7e-55 184.7 2.4 1.1 1 0 0 1 1 1 1 Peptidoglycan-synthase activator LpoB DUF3280 PF11684.8 CAV19252.1 - 0.00088 19.7 0.1 0.0016 18.9 0.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2380) CsgG PF03783.14 CAV19252.1 - 0.0047 16.2 0.2 0.0081 15.5 0.1 1.6 1 1 0 1 1 1 1 Curli production assembly/transport component CsgG TolB_N PF04052.13 CAV19252.1 - 0.012 15.8 0.2 0.059 13.6 0.2 2.1 1 1 0 1 1 1 0 TolB amino-terminal domain LPAM_1 PF08139.12 CAV19252.1 - 0.11 13.0 1.9 0.21 12.2 1.9 1.5 1 0 0 1 1 1 0 Prokaryotic membrane lipoprotein lipid attachment site DUF1425 PF07233.12 CAV19253.1 - 3.8e-29 100.4 0.0 5.6e-29 99.9 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1425) SMG1_N PF17229.2 CAV19253.1 - 0.095 13.4 0.0 0.15 12.8 0.0 1.2 1 0 0 1 1 1 0 Serine/threonine-protein kinase SMG1 N-terminal TPR_2 PF07719.17 CAV19254.1 - 6.9e-06 25.8 2.3 0.026 14.6 0.2 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 CAV19254.1 - 0.0051 16.9 1.0 1.4 9.4 0.2 3.0 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_1 PF00515.28 CAV19254.1 - 0.0087 15.8 2.5 0.047 13.5 0.1 2.7 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_11 PF13414.6 CAV19254.1 - 0.064 13.0 0.6 0.75 9.5 0.2 2.7 2 0 0 2 2 2 0 TPR repeat EXOSC1 PF10447.9 CAV19254.1 - 0.074 13.7 1.2 0.42 11.2 0.1 2.7 3 0 0 3 3 3 0 Exosome component EXOSC1/CSL4 PSII_Pbs31 PF18240.1 CAV19254.1 - 0.42 11.1 3.6 1.2 9.7 0.0 3.1 3 1 0 3 3 3 0 Photosystem II Psb31 protein HIT PF01230.23 CAV19255.1 - 9e-29 100.1 0.0 1e-28 99.9 0.0 1.0 1 0 0 1 1 1 1 HIT domain DcpS_C PF11969.8 CAV19255.1 - 4.3e-23 81.9 0.0 5e-23 81.8 0.0 1.0 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding MCPsignal PF00015.21 CAV19256.1 - 2.8e-44 150.9 20.4 2.8e-44 150.9 20.4 4.1 2 2 1 3 3 3 2 Methyl-accepting chemotaxis protein (MCP) signalling domain HAMP PF00672.25 CAV19256.1 - 4.3e-05 23.8 0.9 0.00023 21.4 0.1 2.7 2 0 0 2 2 2 1 HAMP domain HisKA PF00512.25 CAV19256.1 - 0.0063 16.5 0.3 0.0063 16.5 0.3 3.8 3 2 0 3 3 3 1 His Kinase A (phospho-acceptor) domain COG2 PF06148.11 CAV19256.1 - 0.013 15.5 2.6 0.013 15.5 2.6 5.7 3 3 4 7 7 7 0 COG (conserved oligomeric Golgi) complex component, COG2 Occludin_ELL PF07303.13 CAV19256.1 - 0.03 15.1 1.7 0.03 15.1 1.7 4.6 4 2 0 4 4 4 0 Occludin homology domain Rop-like PF05082.13 CAV19256.1 - 0.14 12.0 0.7 0.85 9.5 0.2 2.7 3 0 0 3 3 3 0 Rop-like Apo-CIII PF05778.12 CAV19256.1 - 3.2 7.4 7.2 2.1 8.1 1.2 3.3 2 0 0 2 2 2 0 Apolipoprotein CIII (Apo-CIII) APG6_N PF17675.1 CAV19256.1 - 7.2 7.1 23.8 0.89 10.1 3.0 3.7 3 0 0 3 3 3 0 Apg6 coiled-coil region SBDS_C PF09377.10 CAV19256.1 - 9 6.4 10.4 0.89 9.6 2.6 2.8 2 0 0 2 2 2 0 SBDS protein C-terminal domain DUF1887 PF09002.11 CAV19257.1 - 1.5e-175 583.4 0.3 1.7e-175 583.2 0.3 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1887) PNP_UDP_1 PF01048.20 CAV19258.1 - 2.5e-38 131.6 2.0 2.8e-38 131.5 2.0 1.0 1 0 0 1 1 1 1 Phosphorylase superfamily E1-E2_ATPase PF00122.20 CAV19259.1 - 2.8e-49 167.1 0.2 2.8e-49 167.1 0.2 2.0 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.26 CAV19259.1 - 4.2e-35 121.9 0.5 7.5e-35 121.1 0.5 1.4 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HMA PF00403.26 CAV19259.1 - 3.3e-12 46.7 0.5 1e-11 45.1 0.5 1.8 1 0 0 1 1 1 1 Heavy-metal-associated domain Hydrolase_3 PF08282.12 CAV19259.1 - 1.5e-05 24.9 0.5 0.00011 22.0 0.3 2.2 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase TusA PF01206.17 CAV19259.1 - 0.046 13.5 0.0 0.46 10.3 0.0 2.5 2 0 0 2 2 2 0 Sulfurtransferase TusA SNN_transmemb PF09049.10 CAV19259.1 - 0.15 12.0 0.1 0.15 12.0 0.1 2.8 3 0 0 3 3 3 0 Stannin transmembrane 7TMR-DISM_7TM PF07695.11 CAV19259.1 - 0.67 9.8 5.3 1.4 8.7 0.5 2.3 2 0 0 2 2 2 0 7TM diverse intracellular signalling MatE PF01554.18 CAV19260.1 - 1.4e-42 145.1 32.9 1.5e-24 86.5 14.6 2.5 2 0 0 2 2 2 2 MatE Polysacc_synt_C PF14667.6 CAV19260.1 - 6.6e-13 48.9 9.5 6.6e-13 48.9 9.5 4.9 3 3 2 5 5 5 1 Polysaccharide biosynthesis C-terminal domain DUF1385 PF07136.11 CAV19260.1 - 0.19 11.0 3.3 0.15 11.3 0.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1385) Orf78 PF06024.12 CAV19260.1 - 0.57 10.5 1.6 7.8 6.9 0.1 2.4 2 0 0 2 2 2 0 Orf78 (ac78) CBS PF00571.28 CAV19261.1 - 9.8e-24 83.6 0.6 9.3e-11 42.0 0.1 2.1 2 0 0 2 2 2 2 CBS domain DUF3659 PF12396.8 CAV19261.1 - 0.15 12.0 0.2 3.9 7.4 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3659) Glycos_trans_3N PF02885.17 CAV19263.1 - 1e-12 47.7 0.0 2.3e-12 46.6 0.0 1.6 1 0 0 1 1 1 1 Glycosyl transferase family, helical bundle domain Glycos_transf_3 PF00591.21 CAV19263.1 - 0.0016 18.1 0.0 0.0053 16.4 0.0 1.7 2 1 1 3 3 3 1 Glycosyl transferase family, a/b domain Arm_3 PF16186.5 CAV19263.1 - 0.059 12.9 0.3 1.2 8.8 0.0 2.6 3 0 0 3 3 3 0 Atypical Arm repeat DUF4322 PF14210.6 CAV19263.1 - 0.11 12.4 0.0 0.24 11.3 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4322) TetR_C_7 PF14246.6 CAV19264.1 - 4.2e-31 107.4 0.2 2e-30 105.3 0.0 2.0 2 0 0 2 2 2 1 AefR-like transcriptional repressor, C-terminal domain TetR_N PF00440.23 CAV19264.1 - 1.1e-16 60.3 0.3 2.3e-16 59.3 0.3 1.5 1 0 0 1 1 1 1 Bacterial regulatory proteins, tetR family HTH_11 PF08279.12 CAV19264.1 - 0.068 13.1 0.1 0.18 11.8 0.0 1.8 2 0 0 2 2 2 0 HTH domain TetR_C_11 PF16859.5 CAV19264.1 - 0.18 12.2 0.0 0.5 10.7 0.0 1.7 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain DSBA PF01323.20 CAV19266.1 - 1.3e-22 80.5 7.6 2.4e-20 73.1 7.6 2.1 1 1 0 1 1 1 1 DSBA-like thioredoxin domain Thioredoxin_4 PF13462.6 CAV19266.1 - 6.4e-13 49.2 0.7 8.8e-13 48.7 0.7 1.2 1 0 0 1 1 1 1 Thioredoxin Thioredoxin PF00085.20 CAV19266.1 - 2.2e-06 27.6 0.2 4.5e-06 26.6 0.2 1.6 1 1 0 1 1 1 1 Thioredoxin DUF3088 PF11287.8 CAV19266.1 - 0.036 13.8 0.1 0.076 12.8 0.1 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3088) Pro_isomerase PF00160.21 CAV19267.1 - 3.9e-45 154.0 0.1 4.3e-45 153.8 0.1 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD MarR PF01047.22 CAV19268.1 - 1.1e-16 60.4 0.2 1.9e-16 59.7 0.2 1.4 1 0 0 1 1 1 1 MarR family MarR_2 PF12802.7 CAV19268.1 - 8e-11 41.7 0.0 1.4e-10 40.9 0.0 1.4 1 0 0 1 1 1 1 MarR family HTH_27 PF13463.6 CAV19268.1 - 1.4e-08 35.1 0.5 1.4e-07 31.9 0.1 2.1 2 0 0 2 2 2 1 Winged helix DNA-binding domain HTH_24 PF13412.6 CAV19268.1 - 1.5e-05 24.5 0.1 3e-05 23.5 0.1 1.5 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding TrmB PF01978.19 CAV19268.1 - 0.00026 20.8 0.0 0.00038 20.3 0.0 1.3 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB HTH_Crp_2 PF13545.6 CAV19268.1 - 0.00095 19.1 0.0 0.002 18.0 0.0 1.6 1 0 0 1 1 1 1 Crp-like helix-turn-helix domain Replic_Relax PF13814.6 CAV19268.1 - 0.0024 18.0 0.0 0.0027 17.8 0.0 1.2 1 0 0 1 1 1 1 Replication-relaxation B-block_TFIIIC PF04182.12 CAV19268.1 - 0.0025 17.9 0.0 0.0037 17.4 0.0 1.4 1 1 0 1 1 1 1 B-block binding subunit of TFIIIC HTH_IclR PF09339.10 CAV19268.1 - 0.0031 17.3 0.0 0.0056 16.5 0.0 1.4 1 0 0 1 1 1 1 IclR helix-turn-helix domain HTH_36 PF13730.6 CAV19268.1 - 0.0058 16.6 0.1 0.0096 15.9 0.1 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain HxlR PF01638.17 CAV19268.1 - 0.01 15.6 0.4 0.019 14.8 0.2 1.6 1 1 0 1 1 1 0 HxlR-like helix-turn-helix HTH_20 PF12840.7 CAV19268.1 - 0.035 14.2 0.4 0.083 13.0 0.1 1.7 2 1 0 2 2 2 0 Helix-turn-helix domain Rrf2 PF02082.20 CAV19268.1 - 0.091 13.1 0.0 0.17 12.3 0.0 1.5 1 0 0 1 1 1 0 Transcriptional regulator PadR PF03551.14 CAV19268.1 - 0.095 12.7 0.2 0.27 11.2 0.2 1.8 1 1 1 2 2 2 0 Transcriptional regulator PadR-like family GntR PF00392.21 CAV19268.1 - 0.1 12.2 0.1 0.2 11.4 0.1 1.4 1 0 0 1 1 1 0 Bacterial regulatory proteins, gntR family Dimerisation2 PF16864.5 CAV19268.1 - 0.14 12.2 0.0 0.23 11.4 0.0 1.3 1 0 0 1 1 1 0 Dimerisation domain Fe_dep_repress PF01325.19 CAV19268.1 - 0.14 12.3 0.8 0.31 11.3 0.0 1.9 2 0 0 2 2 2 0 Iron dependent repressor, N-terminal DNA binding domain EamA PF00892.20 CAV19269.1 - 7.3e-30 103.9 39.4 2.6e-15 56.8 13.0 2.0 2 0 0 2 2 2 2 EamA-like transporter family TPT PF03151.16 CAV19269.1 - 0.00062 19.2 10.0 0.00062 19.2 10.0 2.1 2 0 0 2 2 2 2 Triose-phosphate Transporter family Oxidored_FMN PF00724.20 CAV19270.1 - 2.9e-96 322.7 0.0 3.3e-96 322.5 0.0 1.0 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family Glyoxalase PF00903.25 CAV19271.1 - 9.2e-25 87.3 0.1 1e-24 87.2 0.1 1.0 1 0 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_4 PF13669.6 CAV19271.1 - 6.2e-15 55.4 0.0 5.1e-11 42.8 0.0 1.8 1 1 1 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_6 PF18029.1 CAV19271.1 - 6.2e-07 30.2 0.0 9.6e-07 29.6 0.0 1.3 1 1 0 1 1 1 1 Glyoxalase-like domain Glyoxalase_2 PF12681.7 CAV19271.1 - 0.00022 21.1 0.0 0.00039 20.3 0.0 1.3 1 1 0 1 1 1 1 Glyoxalase-like domain Glyoxalase_3 PF13468.6 CAV19271.1 - 0.069 13.3 0.0 2.7 8.1 0.0 2.1 2 0 0 2 2 2 0 Glyoxalase-like domain CppA_N PF14506.6 CAV19271.1 - 0.1 12.7 0.0 0.15 12.2 0.0 1.3 1 0 0 1 1 1 0 CppA N-terminal HTH_1 PF00126.27 CAV19272.1 - 7e-18 64.3 0.2 1.7e-17 63.1 0.2 1.7 1 0 0 1 1 1 1 Bacterial regulatory helix-turn-helix protein, lysR family LysR_substrate PF03466.20 CAV19272.1 - 2.9e-15 56.2 0.0 4.1e-15 55.7 0.0 1.2 1 0 0 1 1 1 1 LysR substrate binding domain AWPM-19 PF05512.11 CAV19274.1 - 0.012 15.8 2.2 0.018 15.3 2.2 1.4 1 0 0 1 1 1 0 AWPM-19-like family DUF3302 PF11742.8 CAV19274.1 - 0.021 15.0 1.9 0.021 15.0 1.9 2.2 2 1 0 2 2 2 0 Protein of unknown function (DUF3302) Saf_2TM PF18303.1 CAV19274.1 - 0.81 9.3 6.7 2.8 7.5 1.9 2.1 1 1 1 2 2 2 0 SAVED-fused 2TM effector domain ABC2_membrane_3 PF12698.7 CAV19274.1 - 2.4 7.2 8.4 0.08 12.0 1.5 1.8 1 1 1 2 2 2 0 ABC-2 family transporter protein Bac_export_2 PF01312.19 CAV19274.1 - 5.4 6.1 8.3 6.5 5.9 8.3 1.1 1 0 0 1 1 1 0 FlhB HrpN YscU SpaS Family Biotin_lipoyl_2 PF13533.6 CAV19275.1 - 4.4e-09 36.0 1.0 3.6e-07 29.9 0.2 2.5 2 0 0 2 2 2 1 Biotin-lipoyl like HlyD_D23 PF16576.5 CAV19275.1 - 1.5e-07 30.9 0.9 3.3e-07 29.7 0.7 1.6 1 1 0 1 1 1 1 Barrel-sandwich domain of CusB or HlyD membrane-fusion HlyD_3 PF13437.6 CAV19275.1 - 1.8e-07 31.8 0.1 0.0012 19.6 0.0 2.7 2 0 0 2 2 2 2 HlyD family secretion protein TMF_TATA_bd PF12325.8 CAV19275.1 - 0.047 13.9 3.7 0.52 10.6 0.1 2.2 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding Biotin_lipoyl PF00364.22 CAV19275.1 - 0.13 12.1 1.0 2 8.3 0.1 2.5 2 0 0 2 2 2 0 Biotin-requiring enzyme Alkyl_sulf_dimr PF14863.6 CAV19276.1 - 8.9e-42 142.8 3.0 1.7e-41 142.0 3.0 1.5 1 0 0 1 1 1 1 Alkyl sulfatase dimerisation Lactamase_B PF00753.27 CAV19276.1 - 2.7e-18 66.7 0.2 6.9e-18 65.4 0.2 1.7 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Alkyl_sulf_C PF14864.6 CAV19276.1 - 8.2e-13 48.7 0.2 2.8e-12 47.0 0.2 1.9 1 0 0 1 1 1 1 Alkyl sulfatase C-terminal Lactamase_B_2 PF12706.7 CAV19276.1 - 2.4e-07 30.5 0.0 9.8e-07 28.5 0.0 2.1 2 0 0 2 2 2 1 Beta-lactamase superfamily domain ACR_tran PF00873.19 CAV19278.1 - 1.2e-149 500.0 12.4 1.3e-149 499.8 12.4 1.0 1 0 0 1 1 1 1 AcrB/AcrD/AcrF family SecD_SecF PF02355.16 CAV19278.1 - 1.1e-11 44.4 31.1 1.9e-06 27.4 12.2 2.4 2 0 0 2 2 2 2 Protein export membrane protein MMPL PF03176.15 CAV19278.1 - 4.1e-08 32.5 34.3 3.4e-05 23.0 12.3 2.3 2 0 0 2 2 2 2 MMPL family Gly_kinase PF02595.15 CAV19278.1 - 0.032 13.3 0.3 0.05 12.6 0.3 1.2 1 0 0 1 1 1 0 Glycerate kinase family Mpv17_PMP22 PF04117.12 CAV19278.1 - 0.068 13.4 0.3 0.27 11.5 0.2 2.0 2 0 0 2 2 2 0 Mpv17 / PMP22 family Biotin_lipoyl_2 PF13533.6 CAV19279.1 - 2.9e-11 43.0 3.2 8.2e-08 32.0 0.6 3.5 2 2 0 2 2 2 2 Biotin-lipoyl like HlyD_3 PF13437.6 CAV19279.1 - 2.9e-08 34.4 1.2 0.00063 20.4 0.0 3.2 2 1 0 2 2 2 2 HlyD family secretion protein HlyD_D23 PF16576.5 CAV19279.1 - 5.7e-08 32.2 2.2 2.2e-07 30.3 2.2 1.9 1 1 0 1 1 1 1 Barrel-sandwich domain of CusB or HlyD membrane-fusion Biotin_lipoyl PF00364.22 CAV19279.1 - 1.2e-06 28.2 0.3 0.003 17.4 0.0 3.1 3 0 0 3 3 3 2 Biotin-requiring enzyme PTS_EIIA_1 PF00358.20 CAV19279.1 - 0.0055 16.4 0.1 0.036 13.8 0.0 2.3 2 0 0 2 2 2 1 phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1 QSregVF PF13652.6 CAV19279.1 - 0.01 15.9 0.1 0.041 13.9 0.1 1.9 2 0 0 2 2 2 0 Putative quorum-sensing-regulated virulence factor RnfC_N PF13375.6 CAV19279.1 - 0.022 14.7 0.4 0.63 10.0 0.1 2.8 2 1 0 2 2 2 0 RnfC Barrel sandwich hybrid domain TetR_C_7 PF14246.6 CAV19280.1 - 2.8e-16 59.6 0.0 5.6e-16 58.6 0.0 1.4 1 0 0 1 1 1 1 AefR-like transcriptional repressor, C-terminal domain TetR_N PF00440.23 CAV19280.1 - 5.9e-16 58.0 0.0 1.1e-15 57.1 0.0 1.5 1 0 0 1 1 1 1 Bacterial regulatory proteins, tetR family Phage_terminase PF10668.9 CAV19280.1 - 0.00012 22.0 0.0 0.0019 18.1 0.0 2.1 2 0 0 2 2 2 1 Phage terminase small subunit HTH_23 PF13384.6 CAV19280.1 - 0.0014 18.4 0.0 0.0045 16.8 0.0 1.8 2 0 0 2 2 2 1 Homeodomain-like domain HTH_11 PF08279.12 CAV19280.1 - 0.0024 17.8 0.1 0.0083 16.0 0.0 2.0 2 0 0 2 2 2 1 HTH domain HTH_40 PF14493.6 CAV19280.1 - 0.0036 17.7 0.2 0.19 12.2 0.0 2.6 2 1 1 3 3 3 1 Helix-turn-helix domain HTH_7 PF02796.15 CAV19280.1 - 0.0059 16.7 0.0 0.015 15.4 0.0 1.6 1 0 0 1 1 1 1 Helix-turn-helix domain of resolvase LacI PF00356.21 CAV19280.1 - 0.013 15.3 0.0 0.042 13.6 0.0 1.9 2 0 0 2 2 2 0 Bacterial regulatory proteins, lacI family TetR_C_11 PF16859.5 CAV19280.1 - 0.026 14.8 0.0 0.042 14.1 0.0 1.3 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain DUF218 PF02698.17 CAV19280.1 - 0.037 14.1 0.0 0.093 12.7 0.0 1.5 1 1 0 1 1 1 0 DUF218 domain GerE PF00196.19 CAV19280.1 - 0.057 13.0 0.1 0.12 11.9 0.1 1.5 1 0 0 1 1 1 0 Bacterial regulatory proteins, luxR family TnsD PF15978.5 CAV19280.1 - 0.069 12.1 0.1 0.088 11.8 0.1 1.1 1 0 0 1 1 1 0 Tn7-like transposition protein D UPF0122 PF04297.14 CAV19280.1 - 0.08 13.2 0.6 0.21 11.8 0.1 2.0 2 1 0 2 2 2 0 Putative helix-turn-helix protein, YlxM / p13 like Phage_holin_6_1 PF09682.10 CAV19280.1 - 0.088 13.2 0.4 0.15 12.5 0.4 1.4 1 0 0 1 1 1 0 Bacteriophage holin of superfamily 6 (Holin_LLH) HTH_22 PF13309.6 CAV19280.1 - 0.1 12.7 0.0 0.21 11.7 0.0 1.6 1 0 0 1 1 1 0 HTH domain DUF5635 PF18685.1 CAV19280.1 - 0.11 12.5 0.0 0.29 11.1 0.0 1.7 1 0 0 1 1 1 0 Family of unknown function (DUF5635) HTH_10 PF04967.12 CAV19280.1 - 0.11 12.3 0.1 0.37 10.6 0.0 1.8 2 0 0 2 2 2 0 HTH DNA binding domain HTH_29 PF13551.6 CAV19280.1 - 0.17 12.0 0.0 0.8 9.8 0.0 2.0 2 0 0 2 2 2 0 Winged helix-turn helix LysR_substrate PF03466.20 CAV19281.1 - 1.8e-19 70.0 0.0 2.8e-19 69.3 0.0 1.3 1 0 0 1 1 1 1 LysR substrate binding domain HTH_1 PF00126.27 CAV19281.1 - 1.1e-12 47.7 0.1 2.2e-12 46.7 0.1 1.6 1 0 0 1 1 1 1 Bacterial regulatory helix-turn-helix protein, lysR family HTH_30 PF13556.6 CAV19281.1 - 0.0014 18.4 0.1 0.0029 17.4 0.1 1.5 1 0 0 1 1 1 1 PucR C-terminal helix-turn-helix domain ydhR PF08803.11 CAV19282.1 - 2.9e-41 139.3 0.0 3.2e-41 139.1 0.0 1.0 1 0 0 1 1 1 1 Putative mono-oxygenase ydhR Lipocalin_2 PF08212.12 CAV19284.1 - 6.2e-42 143.0 0.0 7.1e-42 142.8 0.0 1.0 1 0 0 1 1 1 1 Lipocalin-like domain Lipocalin PF00061.23 CAV19284.1 - 3.8e-15 56.3 0.0 4.5e-15 56.1 0.0 1.1 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family VDE PF07137.11 CAV19284.1 - 0.0091 15.5 0.2 0.15 11.6 0.2 2.3 1 1 0 1 1 1 1 VDE lipocalin domain ApoM PF11032.8 CAV19284.1 - 0.13 11.9 0.0 4.6 6.9 0.0 2.1 2 0 0 2 2 2 0 ApoM domain Amidohydro_3 PF07969.11 CAV19285.1 - 2.1e-90 304.5 0.0 2.4e-90 304.3 0.0 1.0 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_1 PF01979.20 CAV19285.1 - 4.2e-21 75.6 0.4 5.7e-17 62.1 0.2 2.6 2 1 0 2 2 2 2 Amidohydrolase family RVT_3 PF13456.6 CAV19285.1 - 0.0019 18.0 0.0 0.0047 16.7 0.0 1.7 1 0 0 1 1 1 1 Reverse transcriptase-like MFS_1 PF07690.16 CAV19286.1 - 6.4e-23 81.2 45.3 5.2e-19 68.4 22.3 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily ABC_tran PF00005.27 CAV19287.1 - 3.3e-31 108.6 0.0 4.4e-31 108.2 0.0 1.2 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 CAV19287.1 - 2.2e-09 37.1 0.1 8.7e-05 22.0 0.0 2.1 1 1 1 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 CAV19287.1 - 8.7e-08 32.3 0.1 0.011 15.6 0.0 2.1 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system Rad17 PF03215.15 CAV19287.1 - 0.00017 21.6 0.2 0.0019 18.2 0.0 2.0 2 0 0 2 2 2 1 Rad17 P-loop domain AAA_29 PF13555.6 CAV19287.1 - 0.00029 20.5 0.0 0.00063 19.4 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain TniB PF05621.11 CAV19287.1 - 0.00063 19.2 0.2 0.035 13.5 0.1 2.1 2 0 0 2 2 2 1 Bacterial TniB protein AAA_22 PF13401.6 CAV19287.1 - 0.00074 19.8 0.9 0.006 16.9 0.9 2.1 1 1 0 1 1 1 1 AAA domain AAA_23 PF13476.6 CAV19287.1 - 0.00097 19.7 0.6 0.0016 19.0 0.6 1.3 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 CAV19287.1 - 0.0011 19.3 0.2 0.0043 17.4 0.2 1.9 1 1 0 1 1 1 1 AAA ATPase domain AAA_15 PF13175.6 CAV19287.1 - 0.0016 18.3 0.0 0.0025 17.6 0.0 1.3 1 0 0 1 1 1 1 AAA ATPase domain ABC_ATPase PF09818.9 CAV19287.1 - 0.0024 16.8 1.0 0.46 9.2 0.1 2.8 2 1 0 2 2 2 1 Predicted ATPase of the ABC class RsgA_GTPase PF03193.16 CAV19287.1 - 0.0026 17.7 0.0 0.0053 16.7 0.0 1.4 1 0 0 1 1 1 1 RsgA GTPase AAA_14 PF13173.6 CAV19287.1 - 0.003 17.6 0.1 0.069 13.2 0.1 2.5 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.6 CAV19287.1 - 0.014 15.9 0.0 0.034 14.7 0.0 1.7 2 0 0 2 2 2 0 AAA domain AAA_28 PF13521.6 CAV19287.1 - 0.045 14.0 0.0 0.18 12.0 0.0 1.9 2 0 0 2 2 2 0 AAA domain SbcCD_C PF13558.6 CAV19287.1 - 0.051 13.8 0.1 0.5 10.6 0.1 2.2 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit G-alpha PF00503.20 CAV19287.1 - 0.074 12.2 0.0 0.11 11.6 0.0 1.2 1 0 0 1 1 1 0 G-protein alpha subunit AAA_30 PF13604.6 CAV19287.1 - 0.084 12.6 0.0 1.2 8.8 0.0 2.3 1 1 1 2 2 2 0 AAA domain AAA_33 PF13671.6 CAV19287.1 - 0.088 13.0 0.0 0.38 10.9 0.0 1.9 2 0 0 2 2 2 0 AAA domain ATPase_2 PF01637.18 CAV19287.1 - 0.11 12.4 0.0 0.13 12.1 0.0 1.4 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_13 PF13166.6 CAV19287.1 - 0.17 10.5 0.1 0.82 8.2 0.0 1.8 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 CAV19287.1 - 0.18 12.2 0.0 0.34 11.3 0.0 1.6 1 0 0 1 1 1 0 RNA helicase MMR_HSR1 PF01926.23 CAV19287.1 - 0.18 11.9 0.0 0.7 10.0 0.0 1.8 2 0 0 2 2 2 0 50S ribosome-binding GTPase Peripla_BP_2 PF01497.18 CAV19288.1 - 9.6e-26 90.8 0.2 1.2e-25 90.5 0.2 1.0 1 0 0 1 1 1 1 Periplasmic binding protein FecCD PF01032.18 CAV19289.1 - 1.8e-142 473.9 81.0 8.4e-73 245.1 38.1 2.1 2 0 0 2 2 2 2 FecCD transport family ABC-3 PF00950.17 CAV19289.1 - 0.0002 20.9 16.3 0.0002 20.9 16.3 3.5 3 1 0 3 3 3 2 ABC 3 transport family GntR PF00392.21 CAV19290.1 - 5.7e-13 48.3 0.2 5e-09 35.7 0.0 2.7 3 0 0 3 3 3 2 Bacterial regulatory proteins, gntR family FCD PF07729.12 CAV19290.1 - 9.6e-10 39.0 0.3 2.1e-09 37.8 0.3 1.6 1 0 0 1 1 1 1 FCD domain Rrf2 PF02082.20 CAV19290.1 - 4.3e-05 23.8 0.0 0.026 14.8 0.1 2.7 2 0 0 2 2 2 2 Transcriptional regulator HTH_11 PF08279.12 CAV19290.1 - 0.00052 19.9 0.6 0.037 14.0 0.0 2.8 2 0 0 2 2 2 1 HTH domain HTH_28 PF13518.6 CAV19290.1 - 0.049 13.8 0.0 6.7 6.9 0.0 2.4 2 0 0 2 2 2 0 Helix-turn-helix domain TrmB PF01978.19 CAV19290.1 - 0.056 13.3 0.0 3.2 7.7 0.0 2.3 2 0 0 2 2 2 0 Sugar-specific transcriptional regulator TrmB HTH_41 PF14502.6 CAV19290.1 - 0.077 12.7 0.0 17 5.2 0.0 2.5 2 0 0 2 2 2 0 Helix-turn-helix domain Pro-kuma_activ PF09286.11 CAV19290.1 - 0.078 13.3 0.0 1.6 9.0 0.0 2.4 2 0 0 2 2 2 0 Pro-kumamolisin, activation domain DUF4222 PF13973.6 CAV19290.1 - 0.11 12.1 0.0 0.2 11.3 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4222) Fe_dep_repress PF01325.19 CAV19290.1 - 0.11 12.7 0.2 0.39 10.9 0.1 2.0 2 0 0 2 2 2 0 Iron dependent repressor, N-terminal DNA binding domain TonB_dep_Rec PF00593.24 CAV19291.1 - 7.3e-26 92.1 45.3 7.3e-26 92.1 45.3 1.4 1 1 0 1 1 1 1 TonB dependent receptor Plug PF07715.15 CAV19291.1 - 1.2e-17 64.4 0.6 2.4e-17 63.5 0.6 1.6 1 0 0 1 1 1 1 TonB-dependent Receptor Plug Domain Thioredoxin_4 PF13462.6 CAV19293.1 - 9.8e-13 48.6 0.0 1.8e-12 47.7 0.0 1.4 2 0 0 2 2 2 1 Thioredoxin DSBA PF01323.20 CAV19293.1 - 4.3e-11 43.0 0.0 0.00022 21.1 0.0 2.2 2 0 0 2 2 2 2 DSBA-like thioredoxin domain Thioredoxin_2 PF13098.6 CAV19293.1 - 5.5e-10 39.7 0.0 1.2e-09 38.6 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin-like domain Thioredoxin PF00085.20 CAV19293.1 - 8.8e-05 22.4 0.0 0.0027 17.7 0.0 2.5 2 0 0 2 2 2 1 Thioredoxin Thioredoxin_3 PF13192.6 CAV19293.1 - 0.00044 20.3 0.0 0.16 12.0 0.0 2.5 2 0 0 2 2 2 2 Thioredoxin domain DUF836 PF05768.14 CAV19293.1 - 0.1 13.0 0.0 0.32 11.4 0.0 2.0 1 1 1 2 2 2 0 Glutaredoxin-like domain (DUF836) DUF953 PF06110.11 CAV19293.1 - 0.11 12.1 0.0 0.25 11.0 0.0 1.5 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF953) Thioredoxin PF00085.20 CAV19294.1 - 3.3e-10 39.9 0.3 3.3e-08 33.5 0.3 2.2 1 1 0 1 1 1 1 Thioredoxin Thioredoxin_8 PF13905.6 CAV19294.1 - 7.8e-10 39.0 0.0 1.5e-09 38.0 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin-like Redoxin PF08534.10 CAV19294.1 - 1.1e-08 34.9 0.0 1.6e-08 34.4 0.0 1.2 1 0 0 1 1 1 1 Redoxin AhpC-TSA PF00578.21 CAV19294.1 - 3.5e-08 33.4 0.1 1e-07 31.9 0.1 1.7 1 1 0 1 1 1 1 AhpC/TSA family Thioredoxin_2 PF13098.6 CAV19294.1 - 7.1e-06 26.4 0.1 1.8e-05 25.1 0.1 1.7 1 1 0 1 1 1 1 Thioredoxin-like domain TraF PF13728.6 CAV19294.1 - 4.6e-05 23.3 0.0 0.00014 21.8 0.0 1.8 1 1 0 1 1 1 1 F plasmid transfer operon protein DUF3139 PF11337.8 CAV19294.1 - 0.059 14.0 0.0 0.13 12.9 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3139) Thioredoxin_7 PF13899.6 CAV19294.1 - 0.13 12.5 0.1 0.3 11.3 0.1 1.6 1 0 0 1 1 1 0 Thioredoxin-like DsbC PF11412.8 CAV19295.1 - 2e-13 50.4 0.0 4e-13 49.5 0.0 1.4 1 0 0 1 1 1 1 Disulphide bond corrector protein DsbC DsbD PF02683.15 CAV19295.1 - 1.5e-09 38.1 16.6 3e-09 37.1 16.6 1.4 1 0 0 1 1 1 1 Cytochrome C biogenesis protein transmembrane region Thioredoxin_7 PF13899.6 CAV19295.1 - 2e-07 31.1 0.0 3.7e-07 30.2 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin-like DUF4077 PF13295.6 CAV19295.1 - 0.008 16.1 3.5 0.021 14.8 3.5 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4077) Thioredoxin PF00085.20 CAV19295.1 - 0.02 14.8 0.2 0.04 13.9 0.2 1.4 1 0 0 1 1 1 0 Thioredoxin DUF915 PF06028.11 CAV19297.1 - 8e-08 31.9 0.0 2.8e-05 23.6 0.0 2.3 2 0 0 2 2 2 2 Alpha/beta hydrolase of unknown function (DUF915) DUF900 PF05990.12 CAV19297.1 - 2.1e-06 27.5 0.3 7.2e-06 25.7 0.3 1.9 1 1 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF900) Abhydrolase_1 PF00561.20 CAV19297.1 - 3e-06 27.1 0.2 8.7e-06 25.6 0.2 1.9 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.7 CAV19297.1 - 1.5e-05 24.8 0.0 3e-05 23.8 0.0 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.7 CAV19297.1 - 2.8e-05 24.8 0.0 8.3e-05 23.3 0.0 1.8 2 0 0 2 2 2 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CAV19297.1 - 3e-05 23.4 0.0 0.00093 18.5 0.0 2.2 2 0 0 2 2 2 1 Serine aminopeptidase, S33 DUF676 PF05057.14 CAV19297.1 - 8.6e-05 22.1 0.2 0.0006 19.4 0.2 2.0 1 1 0 1 1 1 1 Putative serine esterase (DUF676) Lipase_2 PF01674.18 CAV19297.1 - 0.00016 21.3 1.6 0.011 15.2 0.8 3.0 3 1 0 3 3 3 1 Lipase (class 2) Palm_thioest PF02089.15 CAV19297.1 - 0.0003 20.7 0.0 0.00045 20.1 0.0 1.3 1 0 0 1 1 1 1 Palmitoyl protein thioesterase PGAP1 PF07819.13 CAV19297.1 - 0.00084 19.1 0.2 0.009 15.8 0.2 2.1 2 0 0 2 2 2 1 PGAP1-like protein LCAT PF02450.15 CAV19297.1 - 0.0025 17.1 0.1 0.0044 16.2 0.1 1.3 1 0 0 1 1 1 1 Lecithin:cholesterol acyltransferase DPBB_1 PF03330.18 CAV19299.1 - 4.3e-30 103.8 0.1 5.9e-30 103.4 0.1 1.2 1 0 0 1 1 1 1 Lytic transglycolase Barwin PF00967.17 CAV19299.1 - 0.0019 18.0 0.0 0.0024 17.7 0.0 1.2 1 0 0 1 1 1 1 Barwin family LPAM_1 PF08139.12 CAV19299.1 - 0.044 14.3 0.7 0.083 13.4 0.7 1.5 1 0 0 1 1 1 0 Prokaryotic membrane lipoprotein lipid attachment site HATPase_c_2 PF13581.6 CAV19299.1 - 0.078 12.9 0.0 0.15 12.0 0.0 1.4 1 0 0 1 1 1 0 Histidine kinase-like ATPase domain Glyoxalase PF00903.25 CAV19300.1 - 1.8e-13 50.8 0.3 2.8e-13 50.2 0.3 1.3 1 1 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_4 PF13669.6 CAV19300.1 - 9.7e-09 35.5 0.0 1.3e-08 35.1 0.0 1.1 1 0 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_6 PF18029.1 CAV19300.1 - 3.1e-05 24.7 0.0 5.3e-05 24.0 0.0 1.4 1 1 0 1 1 1 1 Glyoxalase-like domain Glyoxalase_3 PF13468.6 CAV19300.1 - 0.008 16.3 0.0 0.017 15.2 0.0 1.5 2 0 0 2 2 2 1 Glyoxalase-like domain TPR_7 PF13176.6 CAV19300.1 - 0.012 15.6 0.0 0.032 14.3 0.0 1.7 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_1 PF00515.28 CAV19300.1 - 0.036 13.9 0.0 0.11 12.3 0.0 1.8 2 0 0 2 2 2 0 Tetratricopeptide repeat 3HCDH_N PF02737.18 CAV19300.1 - 0.061 13.2 0.0 0.086 12.7 0.0 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain TPR_8 PF13181.6 CAV19300.1 - 0.079 13.2 0.0 0.24 11.7 0.0 1.8 1 0 0 1 1 1 0 Tetratricopeptide repeat AhpC-TSA PF00578.21 CAV19301.1 - 9.5e-34 116.0 0.1 1.2e-33 115.7 0.1 1.1 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 CAV19301.1 - 2.8e-12 46.6 0.0 3.6e-12 46.2 0.0 1.1 1 0 0 1 1 1 1 Redoxin 1-cysPrx_C PF10417.9 CAV19301.1 - 1.6e-06 27.8 0.1 2.9e-06 27.0 0.1 1.4 1 0 0 1 1 1 1 C-terminal domain of 1-Cys peroxiredoxin SCO1-SenC PF02630.14 CAV19301.1 - 0.00018 21.4 0.0 0.0011 18.9 0.1 2.1 2 0 0 2 2 2 1 SCO1/SenC Pyr_redox_2 PF07992.14 CAV19302.1 - 7e-42 143.7 7.3 1.3e-41 142.8 7.3 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 CAV19302.1 - 2.1e-16 60.0 5.0 6.6e-14 51.9 0.2 2.3 1 1 1 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 CAV19302.1 - 7.4e-14 52.1 12.7 2.6e-10 40.7 0.5 4.2 3 1 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase Thioredoxin_3 PF13192.6 CAV19302.1 - 9.3e-12 44.8 0.2 4.8e-11 42.6 0.0 2.3 2 0 0 2 2 2 1 Thioredoxin domain FAD_binding_2 PF00890.24 CAV19302.1 - 2.8e-08 33.3 19.2 0.00092 18.4 0.2 4.4 3 2 2 5 5 5 2 FAD binding domain GIDA PF01134.22 CAV19302.1 - 8.9e-08 31.6 11.0 0.00017 20.8 3.9 3.5 2 1 1 3 3 3 2 Glucose inhibited division protein A HI0933_like PF03486.14 CAV19302.1 - 5.9e-07 28.5 11.2 0.045 12.4 0.7 4.0 4 0 0 4 4 4 3 HI0933-like protein FAD_oxidored PF12831.7 CAV19302.1 - 2.4e-05 23.9 4.4 2.4e-05 23.9 4.4 4.0 2 2 2 4 4 4 1 FAD dependent oxidoreductase DAO PF01266.24 CAV19302.1 - 3.8e-05 23.4 14.8 0.0061 16.2 1.5 3.6 4 0 0 4 4 4 3 FAD dependent oxidoreductase Glutaredoxin PF00462.24 CAV19302.1 - 6.3e-05 23.1 2.3 0.00013 22.1 0.0 2.7 2 1 1 3 3 3 1 Glutaredoxin NAD_binding_8 PF13450.6 CAV19302.1 - 0.00041 20.5 2.3 0.0075 16.5 0.2 2.5 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain FAD_binding_3 PF01494.19 CAV19302.1 - 0.00078 18.8 0.5 0.00078 18.8 0.5 3.4 3 1 1 4 4 4 1 FAD binding domain Thi4 PF01946.17 CAV19302.1 - 0.002 17.4 3.9 0.0043 16.3 0.1 2.7 2 1 1 3 3 3 1 Thi4 family AlaDh_PNT_C PF01262.21 CAV19302.1 - 0.0023 17.3 5.0 0.37 10.1 0.7 2.8 2 0 0 2 2 2 2 Alanine dehydrogenase/PNT, C-terminal domain Lycopene_cycl PF05834.12 CAV19302.1 - 0.0034 16.5 6.3 0.22 10.5 0.1 3.0 3 0 0 3 3 3 2 Lycopene cyclase protein NAD_binding_7 PF13241.6 CAV19302.1 - 0.0064 16.9 0.6 2.6 8.6 0.1 2.5 2 0 0 2 2 2 1 Putative NAD(P)-binding Thioredoxin_9 PF14595.6 CAV19302.1 - 0.011 15.5 0.1 0.028 14.2 0.1 1.7 1 0 0 1 1 1 0 Thioredoxin Thioredoxin_4 PF13462.6 CAV19302.1 - 0.094 12.9 0.1 0.98 9.6 0.0 2.4 1 1 1 2 2 2 0 Thioredoxin Phage_TTP_13 PF16463.5 CAV19302.1 - 0.1 12.1 0.0 0.28 10.7 0.0 1.8 1 0 0 1 1 1 0 Phage tail tube protein family K_oxygenase PF13434.6 CAV19302.1 - 0.14 11.3 0.5 0.8 8.8 0.0 2.1 2 0 0 2 2 2 0 L-lysine 6-monooxygenase (NADPH-requiring) Trp_halogenase PF04820.14 CAV19302.1 - 0.31 9.8 6.4 2.4 6.9 1.3 3.1 3 0 0 3 3 3 0 Tryptophan halogenase NAD_binding_9 PF13454.6 CAV19302.1 - 0.75 9.8 8.3 0.76 9.8 0.1 3.4 3 0 0 3 3 3 0 FAD-NAD(P)-binding LysE PF01810.18 CAV19303.1 - 1.8e-16 60.2 11.9 2.2e-16 59.9 11.9 1.1 1 0 0 1 1 1 1 LysE type translocator Colicin_V PF02674.16 CAV19303.1 - 5.9e-08 32.8 1.8 5.9e-08 32.8 1.8 2.3 1 1 1 2 2 2 1 Colicin V production protein VIT1 PF01988.19 CAV19303.1 - 0.79 9.6 6.5 0.29 11.0 4.1 1.5 1 1 0 1 1 1 0 VIT family HTH_AsnC-type PF13404.6 CAV19304.1 - 4.9e-19 67.9 0.0 8.2e-19 67.2 0.0 1.4 1 0 0 1 1 1 1 AsnC-type helix-turn-helix domain HTH_24 PF13412.6 CAV19304.1 - 1.4e-18 66.2 0.0 2.4e-18 65.4 0.0 1.4 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding AsnC_trans_reg PF01037.21 CAV19304.1 - 1.1e-09 38.1 0.0 1.6e-09 37.6 0.0 1.2 1 0 0 1 1 1 1 Lrp/AsnC ligand binding domain MarR PF01047.22 CAV19304.1 - 0.00011 22.1 0.0 0.00022 21.1 0.0 1.6 1 0 0 1 1 1 1 MarR family HTH_11 PF08279.12 CAV19304.1 - 0.003 17.5 0.0 0.024 14.6 0.0 2.3 3 0 0 3 3 3 1 HTH domain HTH_27 PF13463.6 CAV19304.1 - 0.023 15.2 0.0 0.042 14.3 0.0 1.4 1 0 0 1 1 1 0 Winged helix DNA-binding domain HTH_20 PF12840.7 CAV19304.1 - 0.093 12.8 0.0 0.16 12.1 0.0 1.3 1 0 0 1 1 1 0 Helix-turn-helix domain UPF0172 PF03665.13 CAV19304.1 - 0.15 12.1 0.0 0.31 11.1 0.0 1.5 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0172) OMP_b-brl PF13505.6 CAV19306.1 - 1.1e-06 28.8 10.7 1.8e-06 28.2 10.7 1.5 1 1 0 1 1 1 1 Outer membrane protein beta-barrel domain OmpA_membrane PF01389.17 CAV19306.1 - 4.3e-05 23.3 0.2 6.9e-05 22.6 0.1 1.4 1 1 0 1 1 1 1 OmpA-like transmembrane domain DUF3551 PF12071.8 CAV19306.1 - 0.14 12.2 0.0 0.21 11.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3551) MerR_1 PF13411.6 CAV19308.1 - 1.3e-16 60.4 0.1 2.4e-16 59.5 0.1 1.5 1 0 0 1 1 1 1 MerR HTH family regulatory protein MerR PF00376.23 CAV19308.1 - 2.1e-15 56.2 0.3 3.6e-15 55.4 0.3 1.4 1 0 0 1 1 1 1 MerR family regulatory protein MerR-DNA-bind PF09278.11 CAV19308.1 - 7.1e-15 55.3 0.2 1.1e-14 54.8 0.2 1.3 1 0 0 1 1 1 1 MerR, DNA binding HTH_3 PF01381.22 CAV19308.1 - 0.031 14.4 0.0 0.063 13.4 0.0 1.6 1 0 0 1 1 1 0 Helix-turn-helix GAS PF13851.6 CAV19308.1 - 0.091 12.1 0.1 0.11 11.8 0.1 1.1 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding LysR_substrate PF03466.20 CAV19310.1 - 1.8e-34 118.9 0.0 2.6e-34 118.4 0.0 1.2 1 0 0 1 1 1 1 LysR substrate binding domain HTH_1 PF00126.27 CAV19310.1 - 7.6e-16 57.8 0.6 1.7e-15 56.7 0.6 1.5 1 0 0 1 1 1 1 Bacterial regulatory helix-turn-helix protein, lysR family ECH_1 PF00378.20 CAV19311.1 - 5.1e-33 114.4 1.0 6.1e-33 114.2 1.0 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 CAV19311.1 - 1.8e-14 54.0 0.2 2.1e-14 53.8 0.2 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase FMN_red PF03358.15 CAV19312.1 - 1.4e-29 102.9 0.0 1.7e-29 102.6 0.0 1.1 1 0 0 1 1 1 1 NADPH-dependent FMN reductase Flavodoxin_2 PF02525.17 CAV19312.1 - 1.7e-09 37.7 0.0 1.9e-09 37.6 0.0 1.2 1 0 0 1 1 1 1 Flavodoxin-like fold Glu_synthase PF01645.17 CAV19313.1 - 1.6e-92 310.5 0.3 5.3e-92 308.8 0.4 1.7 2 0 0 2 2 2 1 Conserved region in glutamate synthase zf-CDGSH PF09360.10 CAV19313.1 - 7.2e-21 74.1 3.2 2.2e-10 40.6 0.1 2.5 2 0 0 2 2 2 2 Iron-binding zinc finger CDGSH type FMN_dh PF01070.18 CAV19313.1 - 2.3e-06 26.9 3.0 3.1e-06 26.5 1.2 2.0 3 0 0 3 3 3 1 FMN-dependent dehydrogenase IMPDH PF00478.25 CAV19313.1 - 0.0044 16.1 0.2 0.012 14.7 0.2 1.6 1 1 1 2 2 2 1 IMP dehydrogenase / GMP reductase domain ThiG PF05690.14 CAV19313.1 - 0.026 13.8 0.3 0.041 13.2 0.3 1.3 1 0 0 1 1 1 0 Thiazole biosynthesis protein ThiG DUF1043 PF06295.12 CAV19313.1 - 0.11 12.4 0.1 0.21 11.6 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1043) DUF1439 PF07273.12 CAV19314.1 - 7.3e-40 136.3 3.5 8.7e-40 136.0 3.5 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1439) DUF3938 PF13074.6 CAV19314.1 - 0.01 16.0 0.1 0.018 15.2 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3938) Sigma54_activat PF00158.26 CAV19316.1 - 2.3e-66 222.7 0.0 3.9e-66 221.9 0.0 1.4 1 0 0 1 1 1 1 Sigma-54 interaction domain Sigma54_activ_2 PF14532.6 CAV19316.1 - 4.4e-27 94.9 0.5 1.8e-26 92.9 0.0 2.3 3 1 0 3 3 1 1 Sigma-54 interaction domain Mg_chelatase PF01078.21 CAV19316.1 - 3.2e-06 26.7 0.0 0.0017 17.8 0.0 2.2 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 CAV19316.1 - 2.6e-05 24.3 0.0 8.3e-05 22.6 0.0 1.9 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) HTH_8 PF02954.19 CAV19316.1 - 3.6e-05 23.5 0.0 7.9e-05 22.4 0.0 1.6 1 0 0 1 1 1 1 Bacterial regulatory protein, Fis family AAA_16 PF13191.6 CAV19316.1 - 8.6e-05 23.0 0.0 0.00017 22.1 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain AAA PF00004.29 CAV19316.1 - 0.00024 21.5 0.0 0.00062 20.2 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) ResIII PF04851.15 CAV19316.1 - 0.0054 16.7 0.0 0.012 15.6 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_7 PF12775.7 CAV19316.1 - 0.0059 16.1 0.0 0.011 15.2 0.0 1.4 1 0 0 1 1 1 1 P-loop containing dynein motor region HTH_17 PF12728.7 CAV19316.1 - 0.0066 16.6 0.1 0.017 15.3 0.1 1.8 1 0 0 1 1 1 1 Helix-turn-helix domain DUF87 PF01935.17 CAV19316.1 - 0.0089 16.1 0.3 3.1 7.9 0.0 2.2 2 0 0 2 2 2 1 Helicase HerA, central domain RWP-RK PF02042.15 CAV19316.1 - 0.014 15.4 0.1 0.045 13.7 0.1 1.9 1 0 0 1 1 1 0 RWP-RK domain HTH_7 PF02796.15 CAV19316.1 - 0.021 14.9 0.4 0.021 14.9 0.4 1.9 2 0 0 2 2 2 0 Helix-turn-helix domain of resolvase AAA_22 PF13401.6 CAV19316.1 - 0.021 15.1 0.0 0.072 13.4 0.0 2.1 1 1 0 1 1 1 0 AAA domain DUF2791 PF10923.8 CAV19316.1 - 0.033 13.0 0.0 0.056 12.3 0.0 1.3 1 0 0 1 1 1 0 P-loop Domain of unknown function (DUF2791) MCM PF00493.23 CAV19316.1 - 0.038 13.1 0.0 0.18 10.9 0.0 1.9 1 1 0 1 1 1 0 MCM P-loop domain HTH_28 PF13518.6 CAV19316.1 - 0.043 14.0 0.1 0.11 12.6 0.1 1.7 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_30 PF13556.6 CAV19316.1 - 0.047 13.5 0.2 0.13 12.1 0.2 1.7 1 0 0 1 1 1 0 PucR C-terminal helix-turn-helix domain Mga PF05043.13 CAV19316.1 - 0.07 13.7 0.5 0.19 12.4 0.5 1.7 1 0 0 1 1 1 0 Mga helix-turn-helix domain AAA_32 PF13654.6 CAV19316.1 - 0.08 11.7 0.0 0.44 9.3 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_30 PF13604.6 CAV19316.1 - 0.087 12.5 0.0 0.3 10.8 0.0 1.9 1 1 0 1 1 1 0 AAA domain AAA_2 PF07724.14 CAV19316.1 - 0.11 12.6 0.0 0.28 11.3 0.0 1.6 1 1 0 1 1 1 0 AAA domain (Cdc48 subfamily) HTH_23 PF13384.6 CAV19316.1 - 0.13 12.1 0.7 0.61 10.0 0.3 2.2 2 0 0 2 2 2 0 Homeodomain-like domain HTH_29 PF13551.6 CAV19316.1 - 0.14 12.2 0.0 0.34 11.0 0.0 1.7 1 0 0 1 1 1 0 Winged helix-turn helix DUF11 PF01345.18 CAV19317.1 - 0.22 11.9 1.5 0.62 10.4 1.5 1.7 1 0 0 1 1 1 0 Domain of unknown function DUF11 AvrRpt-cleavage PF05627.11 CAV19317.1 - 3.6 7.0 5.1 5.6 6.4 0.1 2.7 3 0 0 3 3 3 0 Cleavage site for pathogenic type III effector avirulence factor Avr DUF393 PF04134.12 CAV19318.1 - 4e-25 89.4 0.2 4.5e-25 89.2 0.2 1.0 1 0 0 1 1 1 1 Protein of unknown function, DUF393 DUF836 PF05768.14 CAV19318.1 - 0.0016 18.8 0.0 0.0021 18.4 0.0 1.3 1 0 0 1 1 1 1 Glutaredoxin-like domain (DUF836) tify PF06200.14 CAV19318.1 - 0.014 14.7 0.1 0.025 13.9 0.1 1.4 1 0 0 1 1 1 0 tify domain Anoctamin PF04547.12 CAV19319.1 - 0.069 12.0 1.6 0.061 12.2 1.6 1.0 1 0 0 1 1 1 0 Calcium-activated chloride channel ABC1 PF03109.16 CAV19320.1 - 1.6e-29 102.4 0.0 4.3e-29 101.1 0.0 1.7 1 0 0 1 1 1 1 ABC1 family Diphtheria_C PF02763.14 CAV19320.1 - 0.075 12.7 0.1 0.62 9.7 0.0 2.2 3 0 0 3 3 3 0 Diphtheria toxin, C domain GSHPx PF00255.19 CAV19321.1 - 6.1e-26 90.1 0.1 9.4e-26 89.5 0.1 1.3 1 0 0 1 1 1 1 Glutathione peroxidase Redoxin PF08534.10 CAV19321.1 - 5.8e-05 22.8 0.0 0.00032 20.4 0.0 1.9 1 1 0 1 1 1 1 Redoxin AhpC-TSA PF00578.21 CAV19321.1 - 0.017 15.0 0.0 0.035 14.0 0.0 1.5 2 0 0 2 2 2 0 AhpC/TSA family AHJR-like PF18743.1 CAV19321.1 - 0.021 14.4 0.1 0.078 12.5 0.1 1.9 1 1 0 1 1 1 0 REase_AHJR-like DUF3429 PF11911.8 CAV19322.1 - 1.9e-30 106.0 1.6 2.1e-30 105.9 1.6 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3429) DUF3165 PF11364.8 CAV19322.1 - 0.00048 20.4 1.5 0.029 14.7 0.3 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF3165) Halogen_Hydrol PF10112.9 CAV19322.1 - 0.0024 17.9 0.1 0.0024 17.9 0.1 2.0 1 1 1 2 2 2 1 5-bromo-4-chloroindolyl phosphate hydrolysis protein DUF1097 PF06496.11 CAV19322.1 - 0.01 16.0 2.2 0.015 15.4 1.6 1.5 1 1 1 2 2 2 0 Protein of unknown function (DUF1097) YwiC PF14256.6 CAV19322.1 - 0.029 14.7 0.2 0.045 14.1 0.2 1.2 1 0 0 1 1 1 0 YwiC-like protein IBV_3C PF03620.13 CAV19322.1 - 0.042 14.3 0.5 2.1 8.9 0.0 2.1 1 1 1 2 2 2 0 IBV 3C protein EamA PF00892.20 CAV19322.1 - 1.4 9.1 12.1 4.3 7.5 12.2 1.6 1 1 0 1 1 1 0 EamA-like transporter family LysE PF01810.18 CAV19323.1 - 1.4e-24 86.6 13.5 1.6e-24 86.4 13.5 1.0 1 0 0 1 1 1 1 LysE type translocator ThrE PF06738.12 CAV19323.1 - 0.26 10.6 7.3 0.082 12.3 0.6 2.2 2 0 0 2 2 2 0 Putative threonine/serine exporter TerC PF03741.16 CAV19323.1 - 0.38 10.4 8.7 1.4 8.6 8.7 1.9 1 1 0 1 1 1 0 Integral membrane protein TerC family Polysacc_synt PF01943.17 CAV19325.1 - 2.1e-15 56.8 18.9 2.1e-15 56.8 18.9 2.3 2 1 0 2 2 2 1 Polysaccharide biosynthesis protein Polysacc_synt_3 PF13440.6 CAV19325.1 - 1.1e-11 44.5 12.2 1.1e-11 44.5 12.2 2.2 1 1 1 2 2 2 1 Polysaccharide biosynthesis protein Glycos_transf_2 PF00535.26 CAV19326.1 - 2.7e-30 105.4 0.1 4.3e-30 104.8 0.1 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_2 PF10111.9 CAV19326.1 - 4e-19 69.2 0.6 5e-19 68.8 0.6 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_3 PF13641.6 CAV19326.1 - 8.4e-16 58.5 0.0 1.5e-15 57.7 0.0 1.4 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_4 PF13704.6 CAV19326.1 - 3.7e-05 24.1 0.2 0.00022 21.6 0.2 2.4 1 1 0 1 1 1 1 Glycosyl transferase family 2 Glycos_transf_1 PF00534.20 CAV19327.1 - 4.5e-29 101.2 0.0 7e-29 100.6 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 CAV19327.1 - 6.1e-25 88.2 0.0 1.3e-24 87.1 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_2 PF13524.6 CAV19327.1 - 8.7e-08 32.5 0.1 2.3e-07 31.1 0.0 1.7 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 CAV19327.1 - 1.7e-06 28.1 0.0 3e-06 27.4 0.0 1.5 1 1 0 1 1 1 1 Glycosyltransferase Family 4 RNase_H PF00075.24 CAV19328.1 - 2.8e-27 95.6 0.0 4.1e-27 95.1 0.0 1.2 1 0 0 1 1 1 1 RNase H Cauli_VI PF01693.16 CAV19328.1 - 7.9e-22 77.3 0.6 1.4e-21 76.5 0.6 1.4 1 0 0 1 1 1 1 Caulimovirus viroplasmin AzlD PF05437.12 CAV19331.1 - 1.2e-24 86.3 6.4 1.4e-24 86.1 6.4 1.0 1 0 0 1 1 1 1 Branched-chain amino acid transport protein (AzlD) Spo7 PF03907.13 CAV19331.1 - 0.034 13.6 0.0 0.055 12.9 0.0 1.4 1 1 0 1 1 1 0 Spo7-like protein AzlC PF03591.14 CAV19332.1 - 1.1e-35 123.0 10.1 1.1e-35 123.0 10.1 1.9 2 0 0 2 2 2 1 AzlC protein DUF1056 PF06341.11 CAV19332.1 - 0.016 15.5 0.6 0.016 15.5 0.6 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF1056) YfhO PF09586.10 CAV19332.1 - 0.27 9.4 4.7 0.31 9.2 4.7 1.1 1 0 0 1 1 1 0 Bacterial membrane protein YfhO AraC_binding PF02311.19 CAV19333.1 - 1e-26 93.5 0.2 1.8e-26 92.7 0.2 1.4 1 0 0 1 1 1 1 AraC-like ligand binding domain HTH_18 PF12833.7 CAV19333.1 - 2.8e-20 72.4 0.2 4.6e-20 71.7 0.2 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 CAV19333.1 - 5.7e-18 64.5 0.0 1.7e-10 40.8 0.1 2.4 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family Methyltransf_12 PF08242.12 CAV19335.1 - 2.1e-06 28.4 0.0 3.5e-06 27.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CAV19335.1 - 2.2e-06 27.6 0.0 3.6e-06 26.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CAV19335.1 - 0.00019 22.1 0.0 0.00039 21.1 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CAV19335.1 - 0.0005 20.7 0.0 0.00096 19.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 CAV19335.1 - 0.00079 19.0 0.0 0.0015 18.1 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase small domain Methyltransf_2 PF00891.18 CAV19335.1 - 0.0019 17.5 0.0 0.0033 16.8 0.0 1.5 1 1 0 1 1 1 1 O-methyltransferase domain Methyltransf_PK PF05891.12 CAV19335.1 - 0.0022 17.5 0.0 0.0037 16.8 0.0 1.3 1 0 0 1 1 1 1 AdoMet dependent proline di-methyltransferase Methyltransf_28 PF02636.17 CAV19335.1 - 0.14 11.7 0.0 0.28 10.8 0.0 1.4 1 1 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase DNA_binding_1 PF01035.20 CAV19337.1 - 1.6e-23 82.6 0.0 1.9e-23 82.4 0.0 1.1 1 0 0 1 1 1 1 6-O-methylguanine DNA methyltransferase, DNA binding domain YscW PF09619.10 CAV19338.1 - 2.8e-41 140.2 0.6 3.5e-41 139.9 0.6 1.1 1 0 0 1 1 1 1 Type III secretion system lipoprotein chaperone (YscW) DUF2460 PF09343.10 CAV19338.1 - 0.084 12.4 0.7 0.25 10.8 0.7 1.7 1 1 0 1 1 1 0 Conserved hypothetical protein 2217 (DUF2460) 4HBT_3 PF13622.6 CAV19339.1 - 6e-62 210.1 0.0 7.2e-62 209.9 0.0 1.0 1 0 0 1 1 1 1 Thioesterase-like superfamily Acyl_CoA_thio PF02551.15 CAV19339.1 - 3.6e-53 178.9 0.0 2.8e-41 140.5 0.0 3.0 2 1 0 2 2 2 2 Acyl-CoA thioesterase 4HBT PF03061.22 CAV19339.1 - 0.032 14.6 0.0 0.053 13.9 0.0 1.4 1 0 0 1 1 1 0 Thioesterase superfamily DUF1957 PF09210.11 CAV19339.1 - 0.052 14.0 0.0 0.11 12.9 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1957) DUF948 PF06103.11 CAV19340.1 - 1.5e-07 31.6 3.9 5.2e-05 23.4 1.6 3.1 1 1 1 3 3 3 2 Bacterial protein of unknown function (DUF948) Laminin_II PF06009.12 CAV19340.1 - 0.00053 20.0 0.7 0.0014 18.6 0.2 1.9 2 0 0 2 2 2 1 Laminin Domain II HsbA PF12296.8 CAV19340.1 - 0.00064 20.2 0.1 0.0044 17.4 0.1 2.2 1 1 0 1 1 1 1 Hydrophobic surface binding protein A DUF148 PF02520.17 CAV19340.1 - 0.0097 16.0 0.1 0.02 15.0 0.1 1.6 1 1 0 1 1 1 1 Domain of unknown function DUF148 DUF1664 PF07889.12 CAV19340.1 - 0.01 15.9 0.9 0.025 14.6 0.9 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) Baculo_PEP_C PF04513.12 CAV19340.1 - 0.012 15.7 0.0 0.023 14.7 0.0 1.5 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus AI-2E_transport PF01594.16 CAV19340.1 - 0.013 14.7 0.1 0.02 14.1 0.1 1.4 1 1 0 1 1 1 0 AI-2E family transporter ApoLp-III PF07464.11 CAV19340.1 - 0.021 14.9 0.8 0.058 13.5 0.2 1.9 2 0 0 2 2 2 0 Apolipophorin-III precursor (apoLp-III) PhoU_div PF01865.16 CAV19340.1 - 0.035 13.4 0.1 0.055 12.8 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function DUF47 Laminin_I PF06008.14 CAV19340.1 - 0.05 13.3 0.3 0.14 11.9 0.3 1.6 1 1 0 1 1 1 0 Laminin Domain I zf-C4H2 PF10146.9 CAV19340.1 - 0.05 13.9 0.0 0.062 13.6 0.0 1.1 1 0 0 1 1 1 0 Zinc finger-containing protein Mce4_CUP1 PF11887.8 CAV19340.1 - 0.054 12.9 0.0 0.081 12.4 0.0 1.3 1 0 0 1 1 1 0 Cholesterol uptake porter CUP1 of Mce4, putative COG7 PF10191.9 CAV19340.1 - 0.06 11.6 1.6 0.25 9.6 0.4 1.9 2 0 0 2 2 2 0 Golgi complex component 7 (COG7) Dicty_REP PF05086.12 CAV19340.1 - 0.069 11.1 0.1 0.08 10.9 0.1 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein DUF1858 PF08984.11 CAV19340.1 - 0.077 13.2 0.0 0.17 12.1 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF1858) MCPsignal PF00015.21 CAV19340.1 - 0.089 12.6 0.9 0.17 11.7 0.2 1.8 2 0 0 2 2 2 0 Methyl-accepting chemotaxis protein (MCP) signalling domain FlaC_arch PF05377.11 CAV19340.1 - 0.11 12.9 2.0 2.2 8.7 0.8 2.9 2 1 1 3 3 3 0 Flagella accessory protein C (FlaC) COG2 PF06148.11 CAV19340.1 - 0.16 12.1 2.2 0.33 11.1 0.5 2.2 2 1 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 YabA PF06156.13 CAV19340.1 - 0.21 12.2 0.0 0.58 10.8 0.0 1.8 1 1 1 2 2 2 0 Initiation control protein YabA NPV_P10 PF05531.12 CAV19340.1 - 0.32 11.5 3.1 1.4 9.4 3.1 2.2 1 1 0 1 1 1 0 Nucleopolyhedrovirus P10 protein AsnC_trans_reg PF01037.21 CAV19341.1 - 1.7e-22 79.2 0.0 2.5e-22 78.6 0.0 1.3 1 0 0 1 1 1 1 Lrp/AsnC ligand binding domain HTH_24 PF13412.6 CAV19341.1 - 1.6e-17 62.8 0.5 2.2e-17 62.4 0.5 1.2 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding HTH_AsnC-type PF13404.6 CAV19341.1 - 2.4e-15 56.1 0.1 3.6e-15 55.5 0.1 1.2 1 0 0 1 1 1 1 AsnC-type helix-turn-helix domain HTH_11 PF08279.12 CAV19341.1 - 2.3e-05 24.3 0.2 3.5e-05 23.7 0.2 1.2 1 0 0 1 1 1 1 HTH domain HxlR PF01638.17 CAV19341.1 - 0.0011 18.7 0.0 0.0017 18.2 0.0 1.3 1 0 0 1 1 1 1 HxlR-like helix-turn-helix HTH_Crp_2 PF13545.6 CAV19341.1 - 0.0016 18.4 0.1 0.0024 17.8 0.1 1.3 1 0 0 1 1 1 1 Crp-like helix-turn-helix domain MarR PF01047.22 CAV19341.1 - 0.0023 17.8 0.1 0.0038 17.1 0.1 1.3 1 0 0 1 1 1 1 MarR family HTH_20 PF12840.7 CAV19341.1 - 0.0036 17.3 0.0 0.0058 16.7 0.0 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_5 PF01022.20 CAV19341.1 - 0.006 16.4 0.1 0.013 15.3 0.1 1.6 1 1 0 1 1 1 1 Bacterial regulatory protein, arsR family HTH_27 PF13463.6 CAV19341.1 - 0.0087 16.5 0.1 0.014 15.9 0.1 1.3 1 0 0 1 1 1 1 Winged helix DNA-binding domain LexA_DNA_bind PF01726.16 CAV19341.1 - 0.014 15.2 0.0 0.022 14.6 0.0 1.4 1 0 0 1 1 1 0 LexA DNA binding domain TrmB PF01978.19 CAV19341.1 - 0.025 14.5 0.0 0.04 13.8 0.0 1.4 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB HTH_DeoR PF08220.12 CAV19341.1 - 0.025 14.3 0.1 0.043 13.6 0.1 1.4 1 0 0 1 1 1 0 DeoR-like helix-turn-helix domain DDRGK PF09756.9 CAV19341.1 - 0.041 13.5 0.1 0.064 12.8 0.1 1.2 1 0 0 1 1 1 0 DDRGK domain DUF3083 PF11281.8 CAV19341.1 - 0.11 11.8 0.0 0.13 11.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3083) Rrf2 PF02082.20 CAV19341.1 - 0.17 12.2 0.0 0.31 11.4 0.0 1.4 1 0 0 1 1 1 0 Transcriptional regulator PALP PF00291.25 CAV19342.1 - 2.9e-41 141.8 0.0 3.6e-41 141.5 0.0 1.0 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme DUF1244 PF06844.11 CAV19343.1 - 1.3e-36 124.6 0.3 2.1e-36 123.9 0.3 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1244) Terminase_4 PF05119.12 CAV19343.1 - 0.0003 21.2 0.1 0.00041 20.7 0.1 1.2 1 0 0 1 1 1 1 Phage terminase, small subunit Papo_T_antigen PF02380.15 CAV19343.1 - 0.015 15.4 0.0 0.022 14.9 0.0 1.2 1 0 0 1 1 1 0 T-antigen specific domain Caf4 PF11615.8 CAV19343.1 - 0.13 12.2 0.1 0.26 11.2 0.1 1.5 1 0 0 1 1 1 0 CCR4-associated factor 4 ACR_tran PF00873.19 CAV19344.1 - 3.4e-278 925.5 15.3 3.9e-278 925.3 15.3 1.0 1 0 0 1 1 1 1 AcrB/AcrD/AcrF family MMPL PF03176.15 CAV19344.1 - 2.9e-17 62.6 19.1 5.9e-09 35.3 4.3 2.4 2 0 0 2 2 2 2 MMPL family HlyD_D23 PF16576.5 CAV19345.1 - 1.1e-30 106.5 2.6 1.6e-30 105.9 2.6 1.2 1 0 0 1 1 1 1 Barrel-sandwich domain of CusB or HlyD membrane-fusion HlyD_3 PF13437.6 CAV19345.1 - 5.1e-19 68.9 0.1 2.6e-13 50.6 0.0 2.5 2 0 0 2 2 2 2 HlyD family secretion protein Biotin_lipoyl_2 PF13533.6 CAV19345.1 - 6.5e-15 54.7 2.7 4e-11 42.6 2.0 3.2 2 1 1 3 3 3 2 Biotin-lipoyl like Biotin_lipoyl PF00364.22 CAV19345.1 - 1.6e-06 27.8 0.2 0.02 14.7 0.2 2.8 2 0 0 2 2 2 2 Biotin-requiring enzyme PTS_EIIA_1 PF00358.20 CAV19345.1 - 0.03 14.1 0.3 0.34 10.7 0.1 2.6 2 1 1 3 3 3 0 phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1 CSD2 PF17876.1 CAV19345.1 - 0.12 12.6 0.0 1.4 9.2 0.0 2.6 2 0 0 2 2 2 0 Cold shock domain FLgD_tudor PF13861.6 CAV19345.1 - 0.24 11.7 3.5 1.4 9.2 1.8 3.0 2 1 0 2 2 2 0 FlgD Tudor-like domain Tim44 PF04280.15 CAV19346.1 - 4.6e-16 59.2 0.0 8.4e-16 58.4 0.0 1.4 1 0 0 1 1 1 1 Tim44-like domain SARAF PF06682.12 CAV19346.1 - 0.029 14.0 9.3 0.12 12.0 2.4 2.1 1 1 1 2 2 2 0 SOCE-associated regulatory factor of calcium homoeostasis Phage_holin_8 PF16931.5 CAV19346.1 - 0.044 13.8 0.9 0.071 13.1 0.9 1.3 1 0 0 1 1 1 0 Putative phage holin gerPA PF10676.9 CAV19346.1 - 0.088 13.1 3.3 1.7 9.0 0.5 2.5 2 0 0 2 2 2 0 Spore germination protein gerPA/gerPF TetR_C_33 PF13305.6 CAV19347.1 - 5.3e-15 56.0 0.0 9.4e-15 55.2 0.0 1.4 1 0 0 1 1 1 1 Tetracyclin repressor-like, C-terminal domain HTH_38 PF13936.6 CAV19347.1 - 0.097 12.4 0.0 0.18 11.6 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain TetR_N PF00440.23 CAV19347.1 - 0.1 12.4 0.0 0.2 11.5 0.0 1.5 1 0 0 1 1 1 0 Bacterial regulatory proteins, tetR family LisH PF08513.11 CAV19347.1 - 0.63 10.1 2.2 5.4 7.1 0.6 2.4 2 0 0 2 2 2 0 LisH Acyltransferase PF01553.21 CAV19348.1 - 1.2e-24 86.5 0.0 2e-24 85.7 0.0 1.4 1 0 0 1 1 1 1 Acyltransferase MFS_1 PF07690.16 CAV19348.1 - 3.9e-20 72.1 31.2 3.9e-20 72.1 31.2 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_3 PF05977.13 CAV19348.1 - 9.1e-09 34.2 10.2 1.5e-08 33.5 10.2 1.3 1 0 0 1 1 1 1 Transmembrane secretion effector Cons_hypoth698 PF03601.14 CAV19349.1 - 1.4e-54 185.0 16.5 1.7e-54 184.8 16.5 1.1 1 0 0 1 1 1 1 Conserved hypothetical protein 698 Vps16_C PF04840.12 CAV19350.1 - 0.091 11.8 0.1 0.091 11.8 0.1 1.0 1 0 0 1 1 1 0 Vps16, C-terminal region LysR_substrate PF03466.20 CAV19351.1 - 6.5e-27 94.3 0.0 7.9e-27 94.0 0.0 1.1 1 0 0 1 1 1 1 LysR substrate binding domain HTH_1 PF00126.27 CAV19351.1 - 2.1e-19 69.2 0.5 3.6e-19 68.4 0.5 1.4 1 0 0 1 1 1 1 Bacterial regulatory helix-turn-helix protein, lysR family HTH_24 PF13412.6 CAV19351.1 - 0.07 12.7 0.0 0.16 11.5 0.0 1.6 2 0 0 2 2 2 0 Winged helix-turn-helix DNA-binding HTH_20 PF12840.7 CAV19351.1 - 0.19 11.8 0.0 0.34 11.0 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain PTS_EIIC PF02378.18 CAV19352.1 - 5e-70 236.1 36.4 7e-70 235.6 36.4 1.2 1 0 0 1 1 1 1 Phosphotransferase system, EIIC PTS_EIIB PF00367.20 CAV19352.1 - 6.9e-14 51.1 0.5 1.2e-13 50.3 0.5 1.4 1 0 0 1 1 1 1 phosphotransferase system, EIIB 60KD_IMP PF02096.20 CAV19352.1 - 0.084 12.8 2.2 3 7.7 0.0 2.8 2 1 0 2 2 2 0 60Kd inner membrane protein AMP-binding PF00501.28 CAV19353.1 - 3.1e-48 164.4 0.0 3.9e-48 164.1 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme DUF1706 PF08020.11 CAV19353.1 - 0.045 13.7 0.1 0.091 12.7 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1706) AMP-binding_C PF13193.6 CAV19353.1 - 0.086 13.8 0.0 0.34 11.9 0.0 2.0 2 0 0 2 2 2 0 AMP-binding enzyme C-terminal domain MR_MLE_C PF13378.6 CAV19354.1 - 3.9e-12 46.2 0.0 5.7e-12 45.7 0.0 1.1 1 0 0 1 1 1 1 Enolase C-terminal domain-like ECH_1 PF00378.20 CAV19355.1 - 3.1e-78 262.6 0.0 3.9e-78 262.2 0.0 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 CAV19355.1 - 2.5e-20 73.3 0.1 3.1e-20 72.9 0.1 1.2 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase Abhydrolase_6 PF12697.7 CAV19356.1 - 3.9e-13 50.5 0.0 5.3e-13 50.1 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 CAV19356.1 - 7.1e-10 38.9 0.9 1.6e-09 37.8 0.6 1.7 2 0 0 2 2 2 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 CAV19356.1 - 9.1e-05 21.8 0.1 0.00015 21.1 0.1 1.7 1 1 0 1 1 1 1 Serine aminopeptidase, S33 DUF676 PF05057.14 CAV19356.1 - 0.00035 20.2 0.0 0.00056 19.5 0.0 1.3 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Abhydrolase_2 PF02230.16 CAV19356.1 - 0.0079 16.0 0.0 1.4 8.7 0.0 2.3 2 0 0 2 2 2 2 Phospholipase/Carboxylesterase DUF1611_N PF17396.2 CAV19356.1 - 0.024 14.9 0.0 0.13 12.6 0.0 2.2 2 1 0 2 2 2 0 Domain of unknown function (DUF1611_N) Rossmann-like domain Abhydro_lipase PF04083.16 CAV19356.1 - 0.1 12.2 0.0 0.19 11.4 0.0 1.4 1 0 0 1 1 1 0 Partial alpha/beta-hydrolase lipase region PGAP1 PF07819.13 CAV19356.1 - 0.11 12.2 0.0 0.53 10.0 0.0 2.0 2 0 0 2 2 2 0 PGAP1-like protein TPP_enzyme_M_2 PF16582.5 CAV19357.1 - 2.8e-36 125.2 2.3 4.6e-36 124.5 2.3 1.3 1 0 0 1 1 1 1 Middle domain of thiamine pyrophosphate TPP_enzyme_N PF02776.18 CAV19357.1 - 6.4e-28 97.5 0.5 5.2e-27 94.5 0.0 2.5 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_M PF00205.22 CAV19357.1 - 6.7e-07 29.1 0.0 2.3e-06 27.4 0.0 1.8 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, central domain TPP_enzyme_C PF02775.21 CAV19357.1 - 3.1e-05 23.8 0.7 5.9e-05 22.9 0.2 1.8 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain RMI2 PF16100.5 CAV19357.1 - 0.11 12.3 0.2 0.22 11.4 0.2 1.5 1 0 0 1 1 1 0 RecQ-mediated genome instability protein 2 Chorismate_bind PF00425.18 CAV19358.1 - 4.9e-74 249.1 0.1 8.1e-74 248.4 0.0 1.4 2 0 0 2 2 2 1 chorismate binding enzyme Aminotran_1_2 PF00155.21 CAV19359.1 - 4.5e-48 164.3 0.0 5.4e-48 164.0 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II DegT_DnrJ_EryC1 PF01041.17 CAV19359.1 - 7.4e-06 25.5 0.0 1.2e-05 24.9 0.0 1.2 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_5 PF00266.19 CAV19359.1 - 0.00013 21.0 0.0 0.00021 20.4 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.21 CAV19359.1 - 0.022 14.0 0.0 0.034 13.4 0.0 1.3 1 0 0 1 1 1 0 Beta-eliminating lyase Cys_Met_Meta_PP PF01053.20 CAV19359.1 - 0.16 10.4 0.0 0.24 9.9 0.0 1.2 1 0 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme HD_2 PF12917.7 CAV19361.1 - 1.1e-77 259.9 0.2 1.2e-77 259.7 0.2 1.0 1 0 0 1 1 1 1 HD containing hydrolase-like enzyme HD_3 PF13023.6 CAV19361.1 - 1.5e-14 54.3 0.1 2.5e-14 53.5 0.1 1.3 1 1 0 1 1 1 1 HD domain HD PF01966.22 CAV19361.1 - 0.00011 22.4 0.2 0.00021 21.5 0.2 1.6 1 1 0 1 1 1 1 HD domain HDOD PF08668.12 CAV19361.1 - 0.036 13.5 0.0 0.058 12.9 0.0 1.3 1 0 0 1 1 1 0 HDOD domain HD_assoc PF13286.6 CAV19362.1 - 2.2e-25 89.0 0.4 2.2e-25 89.0 0.4 2.5 3 0 0 3 3 3 1 Phosphohydrolase-associated domain HD PF01966.22 CAV19362.1 - 1.9e-07 31.3 0.2 5.1e-07 29.9 0.0 1.8 2 0 0 2 2 2 1 HD domain DTW PF03942.15 CAV19363.1 - 9.1e-51 172.4 0.3 1e-50 172.2 0.3 1.0 1 0 0 1 1 1 1 DTW domain Rhomboid PF01694.22 CAV19364.1 - 1.1e-12 48.2 12.2 1.1e-12 48.2 12.2 1.5 2 0 0 2 2 2 1 Rhomboid family Arif-1 PF06770.11 CAV19364.1 - 0.045 13.4 3.5 0.5 10.0 0.4 2.4 1 1 1 2 2 2 0 Actin-rearrangement-inducing factor (Arif-1) HHH_3 PF12836.7 CAV19365.1 - 2.4e-22 79.0 0.2 3e-22 78.6 0.2 1.1 1 0 0 1 1 1 1 Helix-hairpin-helix motif HHH PF00633.23 CAV19365.1 - 1.8e-10 40.1 0.2 7e-05 22.5 0.0 2.3 2 0 0 2 2 2 2 Helix-hairpin-helix motif T2SSK PF03934.13 CAV19365.1 - 6.4e-07 29.0 0.0 7.4e-07 28.8 0.0 1.1 1 0 0 1 1 1 1 Type II secretion system (T2SS), protein K HHH_5 PF14520.6 CAV19365.1 - 0.00014 22.4 0.8 0.44 11.2 0.2 2.5 2 1 0 2 2 2 2 Helix-hairpin-helix domain HHH_2 PF12826.7 CAV19365.1 - 0.0012 18.9 0.5 0.13 12.3 0.1 2.1 1 1 1 2 2 2 2 Helix-hairpin-helix motif HHH_6 PF14579.6 CAV19365.1 - 0.0054 17.0 0.1 0.015 15.5 0.1 1.7 1 1 1 2 2 2 1 Helix-hairpin-helix motif HRDC PF00570.23 CAV19365.1 - 0.056 13.4 0.0 1.7 8.7 0.0 2.1 2 0 0 2 2 2 0 HRDC domain TraW_N PF12477.8 CAV19365.1 - 0.097 12.7 0.2 0.25 11.3 0.2 1.7 1 0 0 1 1 1 0 Sex factor F TraW protein N terminal SurA_N_3 PF13624.6 CAV19366.1 - 1.1e-49 168.3 3.9 1.1e-49 168.3 3.9 3.5 4 1 0 4 4 4 1 SurA N-terminal domain SurA_N_2 PF13623.6 CAV19366.1 - 2.9e-36 124.5 2.0 2.9e-36 124.5 2.0 3.4 3 1 1 4 4 4 1 SurA N-terminal domain Rotamase_2 PF13145.6 CAV19366.1 - 5.8e-29 101.4 26.2 5.6e-22 78.8 1.3 4.6 5 0 0 5 5 5 3 PPIC-type PPIASE domain Rotamase_3 PF13616.6 CAV19366.1 - 2.5e-25 89.3 3.1 3.4e-25 88.8 0.1 2.7 2 1 1 3 3 3 1 PPIC-type PPIASE domain Rotamase PF00639.21 CAV19366.1 - 2.2e-22 79.8 0.5 1.5e-21 77.1 0.0 2.8 2 1 0 2 2 2 1 PPIC-type PPIASE domain SurA_N PF09312.11 CAV19366.1 - 3.5e-06 27.1 0.6 3.5e-06 27.1 0.6 3.1 4 0 0 4 4 4 1 SurA N-terminal domain Bac_DNA_binding PF00216.21 CAV19367.1 - 9.1e-33 112.3 0.1 1e-32 112.2 0.1 1.0 1 0 0 1 1 1 1 Bacterial DNA-binding protein HU-HIG PF18291.1 CAV19367.1 - 9.2e-10 38.7 0.0 9.7e-10 38.6 0.0 1.0 1 0 0 1 1 1 1 HU domain fused to wHTH, Ig, or Glycine-rich motif HU-CCDC81_bac_2 PF18175.1 CAV19367.1 - 1.3e-05 24.9 0.0 1.8e-05 24.5 0.0 1.2 1 0 0 1 1 1 1 CCDC81-like prokaryotic HU domain 2 HU-CCDC81_euk_2 PF18289.1 CAV19367.1 - 0.0027 17.8 0.0 0.0037 17.4 0.0 1.2 1 0 0 1 1 1 1 CCDC81 eukaryotic HU domain 2 ACP_syn_III_C PF08541.10 CAV19367.1 - 0.028 14.6 0.1 0.047 13.9 0.1 1.3 1 0 0 1 1 1 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal Arteri_nsp7a PF16749.5 CAV19367.1 - 0.033 14.4 0.1 0.042 14.0 0.1 1.2 1 0 0 1 1 1 0 Arterivirus nonstructural protein 7 alpha HU-CCDC81_euk_1 PF14908.6 CAV19367.1 - 0.12 12.5 0.0 0.12 12.5 0.0 1.1 1 0 0 1 1 1 0 CCDC81 eukaryotic HU domain 1 Lon_C PF05362.13 CAV19368.1 - 6.5e-99 329.5 1.0 1.1e-98 328.8 1.0 1.4 1 0 0 1 1 1 1 Lon protease (S16) C-terminal proteolytic domain LON_substr_bdg PF02190.16 CAV19368.1 - 4.6e-40 137.7 0.9 4.6e-40 137.7 0.9 2.1 2 0 0 2 2 2 1 ATP-dependent protease La (LON) substrate-binding domain AAA PF00004.29 CAV19368.1 - 1.8e-17 64.0 0.0 1e-16 61.6 0.0 2.4 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 CAV19368.1 - 7.2e-10 39.0 0.0 4.8e-09 36.3 0.0 2.5 3 0 0 3 3 3 1 AAA domain (dynein-related subfamily) ChlI PF13541.6 CAV19368.1 - 2.3e-08 33.9 0.3 1.8e-07 31.0 0.0 2.4 2 0 0 2 2 2 1 Subunit ChlI of Mg-chelatase AAA_PrkA PF08298.11 CAV19368.1 - 3.2e-05 23.0 0.0 5.7e-05 22.2 0.0 1.3 1 0 0 1 1 1 1 PrkA AAA domain AAA_16 PF13191.6 CAV19368.1 - 0.00027 21.4 0.0 0.0012 19.3 0.0 2.1 2 0 0 2 2 1 1 AAA ATPase domain AAA_3 PF07726.11 CAV19368.1 - 0.0049 16.7 0.0 0.017 15.0 0.0 1.9 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) IstB_IS21 PF01695.17 CAV19368.1 - 0.007 16.1 0.0 0.015 15.0 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein RuvB_N PF05496.12 CAV19368.1 - 0.007 16.1 0.0 0.034 13.9 0.0 2.2 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_18 PF13238.6 CAV19368.1 - 0.0082 16.7 0.1 0.048 14.2 0.1 2.3 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 CAV19368.1 - 0.01 16.1 0.3 0.16 12.2 0.3 2.6 1 1 0 1 1 1 1 AAA domain AAA_23 PF13476.6 CAV19368.1 - 0.015 15.8 12.5 0.55 10.7 0.0 3.1 2 1 0 2 2 2 0 AAA domain RAB3GAP2_C PF14656.6 CAV19368.1 - 0.018 13.3 1.2 0.028 12.7 1.2 1.2 1 0 0 1 1 1 0 Rab3 GTPase-activating protein regulatory subunit C-terminus NACHT PF05729.12 CAV19368.1 - 0.047 13.6 0.1 1 9.2 0.0 2.5 2 0 0 2 2 2 0 NACHT domain RsgA_GTPase PF03193.16 CAV19368.1 - 0.071 13.0 0.0 0.18 11.7 0.0 1.7 1 0 0 1 1 1 0 RsgA GTPase AAA_assoc_C PF09821.9 CAV19368.1 - 0.084 13.4 0.1 0.084 13.4 0.1 2.5 2 1 0 2 2 2 0 C-terminal AAA-associated domain AAA_14 PF13173.6 CAV19368.1 - 0.086 12.9 0.0 0.25 11.4 0.0 1.9 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 CAV19368.1 - 0.11 13.0 0.5 1.6 9.3 0.0 2.7 2 0 0 2 2 2 0 ABC transporter AAA_33 PF13671.6 CAV19368.1 - 0.15 12.2 0.0 0.41 10.8 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_11 PF13086.6 CAV19368.1 - 1.3 8.7 4.4 52 3.5 0.0 2.5 2 0 0 2 2 2 0 AAA domain Efg1 PF10153.9 CAV19368.1 - 1.7 9.1 8.9 0.27 11.6 2.3 2.5 2 0 0 2 2 2 0 rRNA-processing protein Efg1 AAA_2 PF07724.14 CAV19369.1 - 9.9e-49 165.7 0.0 1.7e-48 164.9 0.0 1.4 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) zf-C4_ClpX PF06689.13 CAV19369.1 - 5.6e-21 74.1 3.8 1.4e-20 72.9 3.8 1.7 1 0 0 1 1 1 1 ClpX C4-type zinc finger ClpB_D2-small PF10431.9 CAV19369.1 - 1.1e-15 57.4 0.3 1.1e-15 57.4 0.3 2.4 3 0 0 3 3 2 1 C-terminal, D2-small domain, of ClpB protein AAA PF00004.29 CAV19369.1 - 8.7e-15 55.3 0.0 2e-14 54.1 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 CAV19369.1 - 8.5e-07 29.1 0.0 2.8e-06 27.4 0.0 1.9 2 0 0 2 2 1 1 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.21 CAV19369.1 - 1.1e-06 28.2 0.1 0.00033 20.1 0.2 2.9 1 1 1 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_22 PF13401.6 CAV19369.1 - 2.3e-06 27.9 0.8 4.7e-05 23.7 0.1 3.0 2 1 0 2 2 2 1 AAA domain RuvB_N PF05496.12 CAV19369.1 - 1.1e-05 25.2 0.1 4e-05 23.4 0.1 1.9 1 1 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain MCM PF00493.23 CAV19369.1 - 1.2e-05 24.6 0.0 1.9e-05 23.9 0.0 1.2 1 0 0 1 1 1 1 MCM P-loop domain Sigma54_activat PF00158.26 CAV19369.1 - 0.00055 19.7 0.0 0.073 12.8 0.0 2.6 2 0 0 2 2 2 1 Sigma-54 interaction domain AAA_16 PF13191.6 CAV19369.1 - 0.00081 19.8 0.3 0.0035 17.8 0.1 2.1 2 1 0 2 2 2 1 AAA ATPase domain AAA_7 PF12775.7 CAV19369.1 - 0.0011 18.5 0.0 0.0023 17.5 0.0 1.4 1 0 0 1 1 1 1 P-loop containing dynein motor region Sigma54_activ_2 PF14532.6 CAV19369.1 - 0.0019 18.3 0.0 0.0037 17.4 0.0 1.5 1 0 0 1 1 1 1 Sigma-54 interaction domain AAA_24 PF13479.6 CAV19369.1 - 0.0021 17.8 0.0 0.0034 17.1 0.0 1.3 1 0 0 1 1 1 1 AAA domain T2SSE PF00437.20 CAV19369.1 - 0.0066 15.5 0.0 0.013 14.6 0.0 1.4 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_14 PF13173.6 CAV19369.1 - 0.0069 16.4 0.0 0.018 15.1 0.0 1.6 1 0 0 1 1 1 1 AAA domain IstB_IS21 PF01695.17 CAV19369.1 - 0.0088 15.8 0.1 0.017 14.9 0.1 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein TIP49 PF06068.13 CAV19369.1 - 0.0089 15.3 0.1 0.064 12.5 0.0 1.9 1 1 1 2 2 2 1 TIP49 P-loop domain AAA_21 PF13304.6 CAV19369.1 - 0.02 14.7 0.0 0.04 13.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system TsaE PF02367.17 CAV19369.1 - 0.025 14.6 0.0 0.05 13.6 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE ABC_tran PF00005.27 CAV19369.1 - 0.026 15.1 0.0 0.077 13.5 0.0 1.8 2 0 0 2 2 1 0 ABC transporter AAA_18 PF13238.6 CAV19369.1 - 0.035 14.6 0.0 0.1 13.1 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 CAV19369.1 - 0.036 14.2 0.0 0.07 13.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 CAV19369.1 - 0.066 13.1 0.0 0.45 10.4 0.0 2.3 2 0 0 2 2 2 0 NACHT domain AAA_28 PF13521.6 CAV19369.1 - 0.069 13.4 0.1 0.38 11.0 0.0 2.2 2 0 0 2 2 2 0 AAA domain ATPase PF06745.13 CAV19369.1 - 0.081 12.3 2.4 2.1 7.6 0.1 2.5 2 1 0 3 3 3 0 KaiC AAA_29 PF13555.6 CAV19369.1 - 0.13 12.0 0.1 0.3 10.9 0.1 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain DEAD PF00270.29 CAV19369.1 - 0.17 11.7 0.7 0.67 9.7 0.1 2.2 2 1 0 3 3 3 0 DEAD/DEAH box helicase AAA_19 PF13245.6 CAV19369.1 - 0.21 11.9 1.3 4.1 7.7 0.1 2.8 2 1 1 3 3 3 0 AAA domain AAA_23 PF13476.6 CAV19369.1 - 0.4 11.2 2.5 1.9 8.9 2.5 2.1 1 1 0 1 1 1 0 AAA domain CLP_protease PF00574.23 CAV19370.1 - 6.3e-90 299.9 0.0 7.4e-90 299.7 0.0 1.0 1 0 0 1 1 1 1 Clp protease Trigger_N PF05697.13 CAV19371.1 - 1.9e-42 144.9 4.7 1.9e-42 144.9 4.7 3.6 3 1 0 4 4 4 1 Bacterial trigger factor protein (TF) Trigger_C PF05698.14 CAV19371.1 - 1.6e-39 135.5 13.2 1.6e-39 135.5 13.2 3.0 3 0 0 3 3 3 1 Bacterial trigger factor protein (TF) C-terminus FKBP_C PF00254.28 CAV19371.1 - 4.1e-13 49.5 0.3 1.7e-12 47.5 0.1 2.1 2 0 0 2 2 2 1 FKBP-type peptidyl-prolyl cis-trans isomerase SurA_N_3 PF13624.6 CAV19371.1 - 0.029 14.2 0.8 0.029 14.2 0.8 3.9 2 1 2 4 4 4 0 SurA N-terminal domain DUF3811 PF11656.8 CAV19371.1 - 0.038 14.4 0.2 0.038 14.4 0.2 2.2 2 0 0 2 2 2 0 YjbD family (DUF3811) YcgL PF05166.13 CAV19371.1 - 0.52 10.7 4.5 1.1 9.6 0.2 2.8 3 0 0 3 3 3 0 YcgL domain HATPase_c PF02518.26 CAV19372.1 - 2.8e-15 56.8 0.0 5.8e-15 55.8 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase dCache_1 PF02743.18 CAV19372.1 - 1.1e-13 51.6 0.6 1.1e-13 51.6 0.6 2.1 2 0 0 2 2 2 1 Cache domain HisKA PF00512.25 CAV19372.1 - 1.2e-10 41.2 0.2 1.2e-10 41.2 0.2 2.5 3 0 0 3 3 3 1 His Kinase A (phospho-acceptor) domain HATPase_c_5 PF14501.6 CAV19372.1 - 2.6e-06 27.3 0.0 7.7e-06 25.7 0.0 1.8 1 0 0 1 1 1 1 GHKL domain DUF4381 PF14316.6 CAV19372.1 - 0.0093 16.2 0.3 0.029 14.6 0.3 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF4381) Thiolase_C PF02803.18 CAV19372.1 - 0.025 14.2 0.1 0.045 13.4 0.1 1.4 1 0 0 1 1 1 0 Thiolase, C-terminal domain HMGL-like PF00682.19 CAV19372.1 - 0.032 13.8 0.1 0.061 12.9 0.1 1.4 1 0 0 1 1 1 0 HMGL-like TSA PF03249.13 CAV19372.1 - 0.035 12.9 0.3 0.058 12.2 0.3 1.2 1 0 0 1 1 1 0 Type specific antigen YkuI_C PF10388.9 CAV19372.1 - 0.042 13.7 2.0 0.16 11.8 0.0 2.6 2 0 0 2 2 2 0 EAL-domain associated signalling protein domain MSC PF09402.10 CAV19372.1 - 0.1 12.0 2.2 0.2 11.1 2.2 1.4 1 0 0 1 1 1 0 Man1-Src1p-C-terminal domain HATPase_c_3 PF13589.6 CAV19372.1 - 0.11 12.3 0.0 0.28 11.0 0.0 1.7 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DUF1003 PF06210.11 CAV19372.1 - 0.33 11.1 2.6 0.57 10.3 0.5 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1003) Sigma54_activat PF00158.26 CAV19373.1 - 7.2e-69 230.8 0.2 1.2e-68 230.1 0.2 1.3 1 0 0 1 1 1 1 Sigma-54 interaction domain Response_reg PF00072.24 CAV19373.1 - 1.1e-24 86.8 0.2 2.1e-24 85.8 0.2 1.5 1 0 0 1 1 1 1 Response regulator receiver domain Sigma54_activ_2 PF14532.6 CAV19373.1 - 4.7e-23 81.8 0.0 1.6e-22 80.1 0.0 2.0 1 1 0 1 1 1 1 Sigma-54 interaction domain HTH_8 PF02954.19 CAV19373.1 - 4.1e-09 36.1 0.0 2.4e-07 30.4 0.0 2.6 2 0 0 2 2 2 1 Bacterial regulatory protein, Fis family AAA_5 PF07728.14 CAV19373.1 - 1.8e-08 34.5 0.1 7.4e-08 32.5 0.0 2.0 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA PF00004.29 CAV19373.1 - 1e-05 25.9 0.0 2.6e-05 24.6 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_7 PF12775.7 CAV19373.1 - 0.00039 20.0 0.0 0.0011 18.5 0.0 1.8 2 0 0 2 2 2 1 P-loop containing dynein motor region Mg_chelatase PF01078.21 CAV19373.1 - 0.0013 18.1 0.1 1.9 7.8 0.0 2.7 3 0 0 3 3 3 2 Magnesium chelatase, subunit ChlI AAA_2 PF07724.14 CAV19373.1 - 0.0021 18.2 0.0 0.0043 17.2 0.0 1.6 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) HTH_30 PF13556.6 CAV19373.1 - 0.011 15.5 0.0 0.059 13.2 0.0 2.2 2 0 0 2 2 2 0 PucR C-terminal helix-turn-helix domain AAA_22 PF13401.6 CAV19373.1 - 0.013 15.8 0.0 0.19 12.0 0.0 2.7 3 1 0 3 3 3 0 AAA domain AAA_3 PF07726.11 CAV19373.1 - 0.013 15.4 0.0 0.031 14.2 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) IstB_IS21 PF01695.17 CAV19373.1 - 0.095 12.4 0.0 0.27 11.0 0.0 1.9 1 0 0 1 1 1 0 IstB-like ATP binding protein DctM PF06808.12 CAV19374.1 - 1.4e-116 389.7 61.9 1.7e-116 389.5 61.9 1.0 1 0 0 1 1 1 1 Tripartite ATP-independent periplasmic transporter, DctM component DctQ PF04290.12 CAV19375.1 - 1.2e-25 89.9 12.8 2e-25 89.2 11.7 1.9 1 1 1 2 2 2 1 Tripartite ATP-independent periplasmic transporters, DctQ component DUF3624 PF12292.8 CAV19375.1 - 0.55 10.7 3.1 2.5 8.6 0.4 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF3624) DctP PF03480.13 CAV19376.1 - 2.3e-103 345.5 2.0 2.7e-103 345.3 2.0 1.0 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein, family 7 Erp_C PF06780.11 CAV19376.1 - 0.0008 19.4 0.5 0.0018 18.3 0.1 1.8 2 0 0 2 2 2 1 Erp protein C-terminus 4HBT PF03061.22 CAV19377.1 - 3.9e-07 30.3 0.0 7.1e-07 29.5 0.0 1.4 2 0 0 2 2 2 1 Thioesterase superfamily 4HBT_2 PF13279.6 CAV19377.1 - 1.2e-06 29.0 0.0 1.9e-06 28.4 0.0 1.3 1 1 0 1 1 1 1 Thioesterase-like superfamily ACPS PF01648.20 CAV19378.1 - 2.5e-18 66.3 0.1 9.4e-18 64.4 0.1 1.9 2 1 0 2 2 2 1 4'-phosphopantetheinyl transferase superfamily Adeno_E1B_19K PF01691.16 CAV19378.1 - 0.079 12.5 0.3 2.4 7.7 0.1 2.3 2 0 0 2 2 2 0 Adenovirus E1B 19K protein / small t-antigen ketoacyl-synt PF00109.26 CAV19379.1 - 1e-64 218.6 0.0 4.4e-64 216.5 0.0 2.2 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain PP-binding PF00550.25 CAV19379.1 - 1.2e-58 195.4 9.1 6.9e-11 42.3 0.1 5.7 5 0 0 5 5 5 5 Phosphopantetheine attachment site Ketoacyl-synt_C PF02801.22 CAV19379.1 - 2.3e-37 127.6 0.4 7.9e-37 125.9 0.4 2.1 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain Acyl_transf_1 PF00698.21 CAV19379.1 - 2.1e-34 119.5 2.0 2.1e-34 119.5 2.0 2.0 2 0 0 2 2 2 1 Acyl transferase domain PS-DH PF14765.6 CAV19379.1 - 1e-31 110.3 0.1 1e-31 110.3 0.1 3.4 4 0 0 4 4 4 2 Polyketide synthase dehydratase KR PF08659.10 CAV19379.1 - 7.3e-30 104.2 0.9 7.3e-30 104.2 0.9 3.8 4 1 0 4 4 4 1 KR domain KAsynt_C_assoc PF16197.5 CAV19379.1 - 1.1e-15 58.1 0.0 4.8e-15 56.0 0.0 2.2 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension adh_short PF00106.25 CAV19379.1 - 0.00043 19.8 10.8 0.0023 17.4 0.1 3.9 4 0 0 4 4 4 2 short chain dehydrogenase FabA PF07977.13 CAV19381.1 - 3.6e-86 285.8 0.0 3.6e-39 133.6 0.0 4.8 4 1 0 4 4 4 3 FabA-like domain ketoacyl-synt PF00109.26 CAV19381.1 - 1.8e-65 221.0 3.7 3.1e-40 138.4 0.0 3.0 3 0 0 3 3 3 2 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.22 CAV19381.1 - 3.9e-38 130.1 0.4 1.7e-34 118.4 0.0 3.9 2 1 0 2 2 2 2 Beta-ketoacyl synthase, C-terminal domain KAsynt_C_assoc PF16197.5 CAV19381.1 - 2e-06 28.2 0.0 2e-06 28.2 0.0 3.2 4 0 0 4 4 4 1 Ketoacyl-synthetase C-terminal extension ACP_syn_III PF08545.10 CAV19381.1 - 0.17 11.7 8.8 0.34 10.8 1.3 3.8 2 2 0 2 2 2 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III PfaD_N PF18328.1 CAV19382.1 - 1.4e-18 66.6 0.0 3e-18 65.5 0.0 1.6 1 0 0 1 1 1 1 Fatty acid synthase subunit PfaD N-terminal domain NMO PF03060.15 CAV19382.1 - 5.4e-06 26.0 1.9 9.9e-06 25.2 1.9 1.3 1 1 0 1 1 1 1 Nitronate monooxygenase DNA_pol_A_exo1 PF01612.20 CAV19383.1 - 1.8e-39 135.2 0.0 3.1e-39 134.5 0.0 1.4 1 0 0 1 1 1 1 3'-5' exonuclease HRDC PF00570.23 CAV19383.1 - 1.5e-11 44.1 0.2 2e-10 40.5 0.1 2.3 2 0 0 2 2 2 1 HRDC domain AMP-binding PF00501.28 CAV19384.1 - 1.2e-106 356.9 0.0 1.4e-106 356.6 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 CAV19384.1 - 7.4e-18 65.3 2.0 4.3e-17 62.8 0.6 2.6 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain Abhydrolase_6 PF12697.7 CAV19385.1 - 1.5e-19 71.4 0.1 1.8e-19 71.2 0.1 1.0 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 CAV19385.1 - 5.6e-19 68.8 1.0 1.3e-18 67.6 1.0 1.7 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 CAV19385.1 - 4.1e-16 59.0 0.5 7.3e-16 58.1 0.5 1.5 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Palm_thioest PF02089.15 CAV19385.1 - 1.5e-05 24.9 0.0 1.8e-05 24.7 0.0 1.2 1 0 0 1 1 1 1 Palmitoyl protein thioesterase Ndr PF03096.14 CAV19385.1 - 0.0001 21.1 0.0 0.00014 20.6 0.0 1.2 1 0 0 1 1 1 1 Ndr family Ser_hydrolase PF06821.13 CAV19385.1 - 0.0057 16.5 0.0 0.016 15.0 0.0 1.7 2 0 0 2 2 2 1 Serine hydrolase Abhydrolase_5 PF12695.7 CAV19385.1 - 0.0081 15.9 0.0 0.37 10.5 0.0 2.3 2 0 0 2 2 2 1 Alpha/beta hydrolase family LIDHydrolase PF10230.9 CAV19385.1 - 0.016 14.8 0.3 0.025 14.1 0.3 1.2 1 0 0 1 1 1 0 Lipid-droplet associated hydrolase Lipase_3 PF01764.25 CAV19385.1 - 0.03 14.2 0.2 0.058 13.2 0.2 1.5 1 1 0 1 1 1 0 Lipase (class 3) DUF676 PF05057.14 CAV19385.1 - 0.04 13.4 0.3 0.1 12.1 0.3 1.6 1 1 0 1 1 1 0 Putative serine esterase (DUF676) Lipase PF00151.19 CAV19385.1 - 0.043 13.1 0.1 0.072 12.4 0.1 1.3 1 1 0 1 1 1 0 Lipase PGAP1 PF07819.13 CAV19385.1 - 0.047 13.4 0.1 0.33 10.6 0.1 2.0 1 1 0 1 1 1 0 PGAP1-like protein FSH1 PF03959.13 CAV19385.1 - 0.068 12.8 0.0 0.65 9.6 0.0 2.0 1 1 0 1 1 1 0 Serine hydrolase (FSH1) Slp PF03843.13 CAV19386.1 - 6.4e-40 136.0 0.0 7.7e-40 135.8 0.0 1.1 1 0 0 1 1 1 1 Outer membrane lipoprotein Slp family Peptidase_M22 PF00814.25 CAV19389.1 - 5.8e-33 114.8 0.0 9.9e-33 114.0 0.0 1.3 1 1 0 1 1 1 1 Glycoprotease family Helicase_C_2 PF13307.6 CAV19390.1 - 6.5e-36 124.1 0.0 9.9e-36 123.5 0.0 1.3 1 0 0 1 1 1 1 Helicase C-terminal domain DEAD PF00270.29 CAV19390.1 - 5.8e-08 32.7 0.2 4.7e-05 23.2 0.0 3.3 4 0 0 4 4 4 1 DEAD/DEAH box helicase ResIII PF04851.15 CAV19390.1 - 1.3e-06 28.5 0.2 4.3e-05 23.6 0.2 2.7 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit DEAD_2 PF06733.15 CAV19390.1 - 0.0016 18.1 0.0 0.0033 17.1 0.0 1.5 1 0 0 1 1 1 1 DEAD_2 Asparaginase PF00710.20 CAV19390.1 - 0.031 13.8 0.0 0.089 12.3 0.0 1.7 2 0 0 2 2 2 0 Asparaginase, N-terminal DUF2075 PF09848.9 CAV19390.1 - 0.033 13.4 0.6 0.07 12.4 0.0 1.7 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) T4SS-DNA_transf PF02534.14 CAV19390.1 - 0.035 12.9 0.0 0.054 12.3 0.0 1.2 1 0 0 1 1 1 0 Type IV secretory system Conjugative DNA transfer T2SSE PF00437.20 CAV19390.1 - 0.051 12.6 0.1 0.1 11.7 0.1 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein POTRA_2 PF08479.11 CAV19390.1 - 0.082 12.8 0.0 0.2 11.5 0.0 1.6 1 0 0 1 1 1 0 POTRA domain, ShlB-type UvrD-helicase PF00580.21 CAV19390.1 - 0.14 11.7 0.1 0.27 10.7 0.1 1.4 1 0 0 1 1 1 0 UvrD/REP helicase N-terminal domain Formyl_trans_N PF00551.19 CAV19392.1 - 1.4e-48 165.0 0.2 1.8e-48 164.7 0.2 1.1 1 0 0 1 1 1 1 Formyl transferase ACT PF01842.25 CAV19392.1 - 3.8e-08 32.9 0.0 9.9e-08 31.6 0.0 1.7 1 0 0 1 1 1 1 ACT domain YecM PF06185.12 CAV19393.1 - 1.4e-69 233.3 0.0 1.6e-69 233.1 0.0 1.0 1 0 0 1 1 1 1 YecM protein Gp-FAR-1 PF05823.12 CAV19393.1 - 0.12 12.7 0.0 0.21 11.9 0.0 1.4 1 0 0 1 1 1 0 Nematode fatty acid retinoid binding protein (Gp-FAR-1) tRNA-synt_1d PF00750.19 CAV19394.1 - 7.1e-160 531.6 2.6 9.5e-160 531.2 2.6 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (R) DALR_1 PF05746.15 CAV19394.1 - 1.5e-37 128.4 3.8 2.9e-37 127.5 0.2 2.7 3 0 0 3 3 3 1 DALR anticodon binding domain Arg_tRNA_synt_N PF03485.16 CAV19394.1 - 1e-20 74.1 0.1 4.2e-20 72.1 0.1 2.1 1 0 0 1 1 1 1 Arginyl tRNA synthetase N terminal domain tRNA-synt_1e PF01406.19 CAV19394.1 - 0.0041 16.5 0.2 0.0072 15.7 0.2 1.3 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain tRNA-synt_1g PF09334.11 CAV19394.1 - 0.027 13.2 0.1 0.069 11.9 0.0 1.7 2 0 0 2 2 2 0 tRNA synthetases class I (M) tRNA-synt_1 PF00133.22 CAV19394.1 - 0.032 12.5 0.0 0.049 11.9 0.0 1.2 1 0 0 1 1 1 0 tRNA synthetases class I (I, L, M and V) HIT PF01230.23 CAV19395.1 - 1.9e-18 67.0 0.1 2.5e-18 66.6 0.1 1.2 1 0 0 1 1 1 1 HIT domain FeoC PF09012.10 CAV19396.1 - 1.5e-12 47.4 0.0 1.8e-12 47.2 0.0 1.1 1 0 0 1 1 1 1 FeoC like transcriptional regulator DUF1627 PF07789.12 CAV19396.1 - 0.0013 18.4 0.0 0.0015 18.2 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1627) DUF4286 PF14114.6 CAV19396.1 - 0.061 13.8 0.0 9.5 6.8 0.0 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4286) FeoB_N PF02421.18 CAV19397.1 - 8.4e-57 191.1 0.1 1.5e-56 190.3 0.1 1.4 1 0 0 1 1 1 1 Ferrous iron transport protein B Gate PF07670.14 CAV19397.1 - 1.5e-50 170.2 9.8 1.1e-35 122.3 0.3 3.0 3 0 0 3 3 3 2 Nucleoside recognition MMR_HSR1 PF01926.23 CAV19397.1 - 1.7e-20 73.2 0.0 2.9e-20 72.5 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_C PF07664.12 CAV19397.1 - 1e-16 60.3 0.1 1e-16 60.3 0.1 2.9 3 0 0 3 3 3 1 Ferrous iron transport protein B C terminus RsgA_GTPase PF03193.16 CAV19397.1 - 1.2e-05 25.3 0.4 0.00098 19.1 0.1 2.3 2 0 0 2 2 2 1 RsgA GTPase SRPRB PF09439.10 CAV19397.1 - 2.6e-05 23.7 0.0 6.7e-05 22.4 0.0 1.6 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit GTP_EFTU PF00009.27 CAV19397.1 - 5.6e-05 22.8 0.6 0.0034 16.9 0.6 2.3 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Dynamin_N PF00350.23 CAV19397.1 - 9.5e-05 22.5 0.1 0.17 11.9 0.0 2.3 1 1 1 2 2 2 2 Dynamin family FeoB_Cyto PF17910.1 CAV19397.1 - 0.00028 21.4 0.0 0.00058 20.3 0.0 1.5 1 0 0 1 1 1 1 FeoB cytosolic helical domain PduV-EutP PF10662.9 CAV19397.1 - 0.0033 17.2 0.0 0.02 14.6 0.0 2.1 1 1 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation ATP_bind_1 PF03029.17 CAV19397.1 - 0.0036 17.1 0.2 0.05 13.4 0.2 2.1 1 1 1 2 2 2 1 Conserved hypothetical ATP binding protein HMGL-like PF00682.19 CAV19397.1 - 0.0057 16.2 0.0 0.0099 15.5 0.0 1.3 1 0 0 1 1 1 1 HMGL-like AIG1 PF04548.16 CAV19397.1 - 0.0079 15.5 0.0 0.014 14.8 0.0 1.4 1 0 0 1 1 1 1 AIG1 family cobW PF02492.19 CAV19397.1 - 0.014 15.0 1.9 7.1 6.2 0.0 3.8 5 0 0 5 5 5 0 CobW/HypB/UreG, nucleotide-binding domain Roc PF08477.13 CAV19397.1 - 0.16 12.2 0.2 0.71 10.1 0.2 2.0 1 1 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase DUF1189 PF06691.11 CAV19397.1 - 1.3 8.6 6.4 7.1 6.1 0.2 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1189) DUF4173 PF13777.6 CAV19397.1 - 1.6 8.1 12.0 0.95 8.9 6.1 2.8 2 1 0 2 2 2 0 Domain of unknown function (DUF4173) FeoA PF04023.14 CAV19398.1 - 5e-17 61.9 1.0 5.4e-17 61.8 1.0 1.0 1 0 0 1 1 1 1 FeoA domain HTH_18 PF12833.7 CAV19400.1 - 4.8e-24 84.4 0.6 1.3e-23 83.1 0.6 1.8 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 CAV19400.1 - 6.5e-13 48.4 4.3 2.4e-08 33.9 0.0 3.1 3 0 0 3 3 3 2 Bacterial regulatory helix-turn-helix proteins, AraC family Reg_prop PF07494.11 CAV19400.1 - 3.8e-08 32.6 5.2 0.0064 16.6 0.0 6.2 7 0 0 7 7 7 2 Two component regulator propeller DUF5074 PF16819.5 CAV19400.1 - 2.1e-05 24.5 4.9 0.00087 19.3 0.1 4.6 4 0 0 4 4 4 1 Domain of unknown function (DUF5074) Fzo_mitofusin PF04799.13 CAV19400.1 - 0.0037 16.8 0.6 0.0083 15.7 0.6 1.6 1 0 0 1 1 1 1 fzo-like conserved region SPK PF04435.18 CAV19400.1 - 0.03 14.7 0.5 0.074 13.5 0.5 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF545) SGL PF08450.12 CAV19400.1 - 0.051 13.2 0.1 14 5.2 0.0 3.3 3 1 0 3 3 3 0 SMP-30/Gluconolactonase/LRE-like region DUF3080 PF11279.8 CAV19400.1 - 1.4 8.0 7.5 0.057 12.6 1.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3080) ZnuA PF01297.17 CAV19401.1 - 6.2e-54 183.1 0.0 6.9e-54 182.9 0.0 1.0 1 0 0 1 1 1 1 Zinc-uptake complex component A periplasmic ABC_tran PF00005.27 CAV19402.1 - 2.4e-29 102.6 0.4 3.5e-29 102.1 0.4 1.3 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 CAV19402.1 - 2.5e-09 37.4 3.3 0.00036 20.4 0.4 2.1 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system RsgA_GTPase PF03193.16 CAV19402.1 - 0.0002 21.3 0.2 0.00039 20.4 0.2 1.4 1 0 0 1 1 1 1 RsgA GTPase AAA_29 PF13555.6 CAV19402.1 - 0.00024 20.8 0.1 0.00051 19.7 0.1 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_15 PF13175.6 CAV19402.1 - 0.00025 20.9 0.1 0.00048 20.0 0.1 1.4 1 1 1 2 2 2 1 AAA ATPase domain SMC_N PF02463.19 CAV19402.1 - 0.00046 19.7 0.5 0.014 14.8 0.5 2.1 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 CAV19402.1 - 0.0016 18.9 0.4 0.0033 17.9 0.4 1.3 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.6 CAV19402.1 - 0.0018 18.6 0.6 0.0055 17.0 0.6 1.8 1 1 0 1 1 1 1 AAA domain AAA_25 PF13481.6 CAV19402.1 - 0.0018 17.9 0.7 0.75 9.3 0.0 2.4 2 1 0 2 2 2 2 AAA domain AAA_16 PF13191.6 CAV19402.1 - 0.011 16.1 0.1 0.017 15.5 0.1 1.4 1 1 0 1 1 1 0 AAA ATPase domain NB-ARC PF00931.22 CAV19402.1 - 0.039 13.1 0.0 0.1 11.8 0.0 1.6 1 1 0 1 1 1 0 NB-ARC domain ABC_ATPase PF09818.9 CAV19402.1 - 0.041 12.7 0.3 4.1 6.1 0.0 2.3 2 1 0 2 2 2 0 Predicted ATPase of the ABC class Rad17 PF03215.15 CAV19402.1 - 0.064 13.2 0.1 0.11 12.4 0.1 1.5 1 1 0 1 1 1 0 Rad17 P-loop domain AAA_30 PF13604.6 CAV19402.1 - 0.069 12.9 0.3 0.17 11.6 0.3 1.7 1 1 0 1 1 1 0 AAA domain AAA_27 PF13514.6 CAV19402.1 - 0.1 12.2 0.9 0.2 11.2 0.0 1.8 2 0 0 2 2 2 0 AAA domain AAA_33 PF13671.6 CAV19402.1 - 0.14 12.3 0.2 0.19 11.9 0.2 1.5 1 1 0 1 1 1 0 AAA domain ABC-3 PF00950.17 CAV19403.1 - 1.5e-75 254.1 30.5 1.7e-75 253.9 30.5 1.0 1 0 0 1 1 1 1 ABC 3 transport family FecCD PF01032.18 CAV19403.1 - 5.9e-06 25.5 28.8 7.7e-06 25.1 28.8 1.3 1 0 0 1 1 1 1 FecCD transport family CoA_binding PF02629.19 CAV19404.1 - 6.4e-31 106.9 1.0 6.4e-31 106.9 1.0 2.3 3 1 0 3 3 3 1 CoA binding domain Ligase_CoA PF00549.19 CAV19404.1 - 7.8e-23 81.0 0.4 1.2e-22 80.3 0.4 1.3 1 0 0 1 1 1 1 CoA-ligase Succ_CoA_lig PF13607.6 CAV19404.1 - 1.2e-10 41.3 0.0 2e-10 40.6 0.0 1.4 1 0 0 1 1 1 1 Succinyl-CoA ligase like flavodoxin domain CoA_binding_2 PF13380.6 CAV19404.1 - 0.001 19.5 0.1 0.0033 17.9 0.0 1.9 2 0 0 2 2 2 1 CoA binding domain ATP-grasp_2 PF08442.10 CAV19405.1 - 2.8e-78 262.1 0.1 4.1e-78 261.6 0.1 1.2 1 0 0 1 1 1 1 ATP-grasp domain Ligase_CoA PF00549.19 CAV19405.1 - 1.4e-24 86.6 3.5 2.4e-24 85.9 3.5 1.4 1 0 0 1 1 1 1 CoA-ligase ATP-grasp_5 PF13549.6 CAV19405.1 - 2.5e-13 50.0 0.0 5.1e-13 49.0 0.0 1.6 1 0 0 1 1 1 1 ATP-grasp domain 2-oxoacid_dh PF00198.23 CAV19406.1 - 2.2e-82 276.0 0.0 2.9e-82 275.6 0.0 1.1 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.22 CAV19406.1 - 1.9e-18 66.1 1.3 3.9e-18 65.0 1.3 1.6 1 0 0 1 1 1 1 Biotin-requiring enzyme E3_binding PF02817.17 CAV19406.1 - 3e-13 49.9 0.3 8.9e-13 48.3 0.3 1.9 1 0 0 1 1 1 1 e3 binding domain Transket_pyr PF02779.24 CAV19407.1 - 3e-66 222.5 0.0 5.4e-66 221.7 0.0 1.4 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain OxoGdeHyase_C PF16870.5 CAV19407.1 - 3.5e-53 179.4 0.0 7.3e-53 178.3 0.0 1.6 1 0 0 1 1 1 1 2-oxoglutarate dehydrogenase C-terminal E1_dh PF00676.20 CAV19407.1 - 1.7e-48 165.2 0.0 3.1e-48 164.3 0.0 1.4 1 0 0 1 1 1 1 Dehydrogenase E1 component 2-oxogl_dehyd_N PF16078.5 CAV19407.1 - 1.3e-16 59.9 0.5 4.3e-16 58.2 0.3 2.1 2 0 0 2 2 2 1 2-oxoglutarate dehydrogenase N-terminus PFOR_II PF17147.4 CAV19407.1 - 0.0025 18.1 0.0 0.009 16.3 0.0 1.9 1 0 0 1 1 1 1 Pyruvate:ferredoxin oxidoreductase core domain II Fer2_3 PF13085.6 CAV19408.1 - 3.9e-30 104.0 0.0 6.2e-30 103.4 0.0 1.3 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain Fer4_17 PF13534.6 CAV19408.1 - 1.5e-10 41.4 1.4 2.8e-10 40.6 1.4 1.4 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_8 PF13183.6 CAV19408.1 - 1.1e-08 35.3 4.1 4.6e-07 30.2 5.2 2.2 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_10 PF13237.6 CAV19408.1 - 3.5e-08 33.4 1.7 6.5e-08 32.6 1.7 1.4 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_7 PF12838.7 CAV19408.1 - 0.00042 20.8 7.3 0.0022 18.5 7.7 2.0 1 1 1 2 2 2 1 4Fe-4S dicluster domain Fer4_9 PF13187.6 CAV19408.1 - 0.0025 18.0 7.9 0.047 13.9 8.9 2.3 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_18 PF13746.6 CAV19408.1 - 0.006 16.8 2.6 0.99 9.6 0.1 2.5 3 0 0 3 3 3 2 4Fe-4S dicluster domain Fer2 PF00111.27 CAV19408.1 - 0.018 15.0 0.4 0.39 10.7 0.0 2.5 3 0 0 3 3 2 0 2Fe-2S iron-sulfur cluster binding domain Fer4_4 PF12800.7 CAV19408.1 - 0.047 14.2 9.2 0.6 10.8 3.1 2.6 2 0 0 2 2 2 0 4Fe-4S binding domain Fer4 PF00037.27 CAV19408.1 - 0.099 12.5 0.8 0.099 12.5 0.8 2.6 2 0 0 2 2 2 0 4Fe-4S binding domain Fer4_21 PF14697.6 CAV19408.1 - 0.15 12.2 7.0 6.4 7.0 3.1 2.3 2 0 0 2 2 2 0 4Fe-4S dicluster domain Fer4_6 PF12837.7 CAV19408.1 - 0.18 12.0 0.6 0.18 12.0 0.6 2.5 2 0 0 2 2 2 0 4Fe-4S binding domain Fer4_15 PF13459.6 CAV19408.1 - 0.72 10.6 4.8 10 6.9 0.0 2.5 2 0 0 2 2 2 0 4Fe-4S single cluster domain Fer4_16 PF13484.6 CAV19408.1 - 1.8 9.6 11.4 36 5.4 12.2 2.3 1 1 1 2 2 2 0 4Fe-4S double cluster binding domain Fer4_3 PF12798.7 CAV19408.1 - 6.8 7.9 22.9 1.6 9.8 2.6 2.7 3 0 0 3 3 2 0 4Fe-4S binding domain FAD_binding_2 PF00890.24 CAV19409.1 - 3.8e-117 391.9 5.1 4.7e-117 391.6 5.1 1.1 1 0 0 1 1 1 1 FAD binding domain Succ_DH_flav_C PF02910.20 CAV19409.1 - 5.7e-29 100.7 1.3 9.1e-29 100.0 1.3 1.3 1 0 0 1 1 1 1 Fumarate reductase flavoprotein C-term Pyr_redox_2 PF07992.14 CAV19409.1 - 0.00015 21.1 1.8 0.0017 17.6 0.5 2.6 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 CAV19409.1 - 0.00023 20.4 2.9 0.0018 17.5 0.8 2.4 2 0 0 2 2 2 1 Glucose inhibited division protein A HI0933_like PF03486.14 CAV19409.1 - 0.00097 17.9 1.2 0.0034 16.1 0.1 2.4 3 0 0 3 3 3 1 HI0933-like protein Thi4 PF01946.17 CAV19409.1 - 0.0071 15.6 0.3 0.094 11.9 0.1 2.2 2 0 0 2 2 2 1 Thi4 family FAD_binding_3 PF01494.19 CAV19409.1 - 0.01 15.1 0.2 0.021 14.1 0.2 1.5 1 0 0 1 1 1 0 FAD binding domain DAO PF01266.24 CAV19409.1 - 0.026 14.1 2.6 0.051 13.1 2.4 1.6 1 1 0 1 1 1 0 FAD dependent oxidoreductase OPA3 PF07047.12 CAV19409.1 - 0.03 14.1 0.0 0.056 13.2 0.0 1.4 1 0 0 1 1 1 0 Optic atrophy 3 protein (OPA3) Lycopene_cycl PF05834.12 CAV19409.1 - 0.043 12.9 0.0 0.075 12.1 0.0 1.4 1 0 0 1 1 1 0 Lycopene cyclase protein FAD_oxidored PF12831.7 CAV19409.1 - 0.071 12.5 0.7 0.34 10.2 0.2 2.2 2 0 0 2 2 2 0 FAD dependent oxidoreductase BEX PF04538.12 CAV19409.1 - 0.18 12.4 0.3 0.36 11.4 0.3 1.4 1 0 0 1 1 1 0 Brain expressed X-linked like family Sdh_cyt PF01127.22 CAV19410.1 - 3.7e-06 27.0 7.8 4.4e-06 26.7 7.8 1.1 1 0 0 1 1 1 1 Succinate dehydrogenase/Fumarate reductase transmembrane subunit Fumarate_red_C PF02300.17 CAV19410.1 - 0.0083 16.2 4.1 0.0094 16.0 3.4 1.2 1 1 0 1 1 1 1 Fumarate reductase subunit C CybS PF05328.12 CAV19410.1 - 0.011 15.5 0.4 0.011 15.5 0.4 1.7 2 0 0 2 2 2 0 CybS, succinate dehydrogenase cytochrome B small subunit Sdh_cyt PF01127.22 CAV19411.1 - 2.7e-29 101.6 4.3 3.1e-29 101.5 4.3 1.0 1 0 0 1 1 1 1 Succinate dehydrogenase/Fumarate reductase transmembrane subunit Citrate_synt PF00285.21 CAV19412.1 - 8.2e-135 449.5 0.0 9.5e-135 449.3 0.0 1.0 1 0 0 1 1 1 1 Citrate synthase, C-terminal domain NIF3 PF01784.18 CAV19413.1 - 3.7e-61 206.9 0.0 4.5e-61 206.6 0.0 1.0 1 0 0 1 1 1 1 NIF3 (NGG1p interacting factor 3) DUF1853 PF08907.11 CAV19414.1 - 1.6e-33 116.6 0.6 5.5e-33 114.9 0.6 1.7 1 1 0 1 1 1 1 Domain of unknown function (DUF1853) PGM_PMM_I PF02878.16 CAV19415.1 - 9.4e-40 135.5 0.6 9.4e-39 132.3 0.3 2.4 2 0 0 2 2 2 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_III PF02880.16 CAV19415.1 - 1e-28 99.8 0.0 3.2e-28 98.2 0.0 1.9 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_II PF02879.16 CAV19415.1 - 3.6e-17 62.9 0.1 1.8e-16 60.6 0.0 2.3 2 0 0 2 2 2 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_IV PF00408.20 CAV19415.1 - 7.5e-09 35.6 0.0 2.3e-08 34.1 0.0 1.9 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain SeqA PF03925.13 CAV19416.1 - 4.3e-46 155.4 0.3 5.7e-46 155.0 0.3 1.1 1 0 0 1 1 1 1 SeqA protein C-terminal domain SeqA_N PF17206.3 CAV19416.1 - 2.1e-22 78.1 0.4 3.3e-22 77.5 0.4 1.3 1 0 0 1 1 1 1 SeqA protein N-terminal domain Hydrolase_6 PF13344.6 CAV19416.1 - 0.0094 16.0 0.1 0.015 15.4 0.1 1.6 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase VAPB_antitox PF02697.14 CAV19416.1 - 0.2 12.4 1.2 0.82 10.5 0.1 2.5 2 1 1 3 3 3 0 Putative antitoxin Abhydrolase_6 PF12697.7 CAV19417.1 - 2.1e-22 80.8 0.0 2.4e-22 80.6 0.0 1.0 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 CAV19417.1 - 2.9e-19 69.7 1.5 3.6e-14 53.0 0.1 2.1 1 1 1 2 2 2 2 alpha/beta hydrolase fold PGAP1 PF07819.13 CAV19417.1 - 7.5e-16 58.6 2.1 9.8e-14 51.6 2.1 2.7 1 1 0 1 1 1 1 PGAP1-like protein Hydrolase_4 PF12146.8 CAV19417.1 - 2.8e-11 43.2 0.8 2.8e-10 39.9 0.3 2.0 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Thioesterase PF00975.20 CAV19417.1 - 8.3e-08 32.6 0.1 1e-07 32.3 0.1 1.4 1 1 0 1 1 1 1 Thioesterase domain DUF676 PF05057.14 CAV19417.1 - 7.2e-05 22.4 0.4 0.00011 21.8 0.4 1.3 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Palm_thioest PF02089.15 CAV19417.1 - 0.00053 19.9 0.1 0.00069 19.5 0.1 1.2 1 0 0 1 1 1 1 Palmitoyl protein thioesterase BAAT_C PF08840.11 CAV19417.1 - 0.00088 19.2 0.1 0.0015 18.5 0.1 1.4 1 0 0 1 1 1 1 BAAT / Acyl-CoA thioester hydrolase C terminal Lipase PF00151.19 CAV19417.1 - 0.001 18.4 0.1 0.0018 17.7 0.1 1.3 1 0 0 1 1 1 1 Lipase DUF900 PF05990.12 CAV19417.1 - 0.0014 18.1 0.2 0.0022 17.5 0.2 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF900) PAF-AH_p_II PF03403.13 CAV19417.1 - 0.0016 17.0 0.0 0.002 16.7 0.0 1.2 1 0 0 1 1 1 1 Platelet-activating factor acetylhydrolase, isoform II UPF0227 PF05728.12 CAV19417.1 - 0.0027 17.7 0.6 0.0044 17.0 0.6 1.6 1 1 0 1 1 1 1 Uncharacterised protein family (UPF0227) Lipase_3 PF01764.25 CAV19417.1 - 0.0029 17.5 0.5 0.0085 16.0 0.2 1.9 2 1 0 2 2 2 1 Lipase (class 3) Ndr PF03096.14 CAV19417.1 - 0.015 14.0 0.3 0.23 10.1 0.3 2.1 1 1 0 1 1 1 0 Ndr family Chlorophyllase2 PF12740.7 CAV19417.1 - 0.016 14.2 0.0 0.023 13.6 0.0 1.3 1 0 0 1 1 1 0 Chlorophyllase enzyme Abhydrolase_3 PF07859.13 CAV19417.1 - 0.02 14.7 0.0 0.027 14.3 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold Esterase PF00756.20 CAV19417.1 - 0.042 13.5 0.4 0.16 11.6 0.1 2.0 2 1 0 3 3 3 0 Putative esterase Chlorophyllase PF07224.11 CAV19417.1 - 0.056 12.5 0.0 0.11 11.5 0.0 1.5 1 0 0 1 1 1 0 Chlorophyllase DUF1057 PF06342.12 CAV19417.1 - 0.073 12.1 0.8 0.17 10.9 0.7 1.8 1 1 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF1057) Pro_CA PF00484.19 CAV19417.1 - 0.089 13.1 0.3 0.16 12.2 0.1 1.5 2 0 0 2 2 1 0 Carbonic anhydrase ATP1G1_PLM_MAT8 PF02038.16 CAV19418.1 - 3.1 7.3 5.5 5.2 6.6 5.5 1.5 1 1 0 1 1 1 0 ATP1G1/PLM/MAT8 family Flavodoxin_1 PF00258.25 CAV19419.1 - 4.5e-32 111.2 0.3 5.4e-32 111.0 0.3 1.1 1 0 0 1 1 1 1 Flavodoxin Flavodoxin_3 PF12641.7 CAV19419.1 - 4.5e-09 36.2 0.0 8.5e-09 35.3 0.0 1.6 1 1 0 1 1 1 1 Flavodoxin domain Flavodoxin_5 PF12724.7 CAV19419.1 - 2.2e-06 28.0 0.0 3e-06 27.5 0.0 1.2 1 0 0 1 1 1 1 Flavodoxin domain DUF1598 PF07643.11 CAV19419.1 - 0.056 13.7 0.2 0.37 11.1 0.1 2.2 3 0 0 3 3 3 0 Protein of unknown function (DUF1598) DUF4442 PF14539.6 CAV19420.1 - 6.1e-25 87.9 0.0 7e-25 87.7 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4442) 4HBT PF03061.22 CAV19420.1 - 0.055 13.8 0.0 0.11 12.8 0.0 1.5 1 0 0 1 1 1 0 Thioesterase superfamily FUR PF01475.19 CAV19421.1 - 1.4e-46 157.5 0.2 1.7e-46 157.3 0.2 1.0 1 0 0 1 1 1 1 Ferric uptake regulator family HTH_12 PF08461.10 CAV19421.1 - 0.006 16.5 0.0 0.015 15.2 0.0 1.6 2 0 0 2 2 2 1 Ribonuclease R winged-helix domain TF_Zn_Ribbon PF08271.12 CAV19421.1 - 0.053 13.0 0.1 0.1 12.1 0.1 1.5 1 0 0 1 1 1 0 TFIIB zinc-binding PadR PF03551.14 CAV19421.1 - 0.11 12.4 0.0 0.21 11.5 0.0 1.5 1 0 0 1 1 1 0 Transcriptional regulator PadR-like family HTH_Tnp_Tc3_2 PF01498.18 CAV19421.1 - 0.13 12.5 0.0 1.9 8.8 0.0 2.2 1 1 1 2 2 2 0 Transposase SR1P PF13790.6 CAV19421.1 - 1.6 8.9 5.2 12 6.1 0.3 3.0 3 0 0 3 3 3 0 SR1 protein tRNA-synt_1c PF00749.21 CAV19422.1 - 1.8e-124 414.7 0.0 2.3e-124 414.4 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain tRNA-synt_1c_C PF03950.18 CAV19422.1 - 3.4e-63 212.7 0.0 6.4e-63 211.7 0.0 1.5 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), anti-codon binding domain PTS_EIIC PF02378.18 CAV19423.1 - 3.9e-63 213.4 34.5 3.9e-63 213.4 34.5 2.1 2 1 0 2 2 2 1 Phosphotransferase system, EIIC PTS_EIIB PF00367.20 CAV19423.1 - 7.6e-14 50.9 0.1 1.6e-13 49.9 0.1 1.6 1 0 0 1 1 1 1 phosphotransferase system, EIIB HupE_UreJ_2 PF13795.6 CAV19423.1 - 0.015 15.0 3.4 0.015 15.0 3.4 2.3 3 0 0 3 3 3 0 HupE / UreJ protein Amidohydro_1 PF01979.20 CAV19424.1 - 1.2e-36 126.8 3.0 1.6e-36 126.4 3.0 1.1 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 CAV19424.1 - 2.5e-09 37.1 0.1 1.5e-07 31.3 0.1 2.4 2 0 0 2 2 2 2 Amidohydrolase family ROK PF00480.20 CAV19425.1 - 1.4e-72 244.6 1.8 1.9e-72 244.2 1.8 1.2 1 0 0 1 1 1 1 ROK family MarR PF01047.22 CAV19425.1 - 4.5e-06 26.5 0.0 2.3e-05 24.2 0.0 2.1 2 0 0 2 2 2 1 MarR family HTH_24 PF13412.6 CAV19425.1 - 0.00032 20.2 0.1 0.0057 16.2 0.1 2.5 2 0 0 2 2 2 1 Winged helix-turn-helix DNA-binding Fe_dep_repress PF01325.19 CAV19425.1 - 0.00075 19.6 0.0 0.0036 17.5 0.0 2.0 2 0 0 2 2 2 1 Iron dependent repressor, N-terminal DNA binding domain MarR_2 PF12802.7 CAV19425.1 - 0.0014 18.5 0.5 0.0073 16.2 0.4 2.2 2 0 0 2 2 2 1 MarR family SMC_ScpB PF04079.16 CAV19425.1 - 0.0071 16.0 0.1 0.017 14.8 0.1 1.6 1 0 0 1 1 1 1 Segregation and condensation complex subunit ScpB HTH_Crp_2 PF13545.6 CAV19425.1 - 0.048 13.6 0.1 0.13 12.2 0.1 1.7 1 0 0 1 1 1 0 Crp-like helix-turn-helix domain tRNA_NucTran2_2 PF13735.6 CAV19425.1 - 0.13 12.2 0.0 0.26 11.3 0.0 1.4 1 0 0 1 1 1 0 tRNA nucleotidyltransferase domain 2 putative Na_H_Exchanger PF00999.21 CAV19426.1 - 1.3e-35 123.0 49.1 8.9e-35 120.2 49.1 1.9 1 1 0 1 1 1 1 Sodium/hydrogen exchanger family TrkA_N PF02254.18 CAV19426.1 - 2e-19 70.0 0.0 3.3e-19 69.3 0.0 1.4 1 0 0 1 1 1 1 TrkA-N domain Epimerase PF01370.21 CAV19426.1 - 0.014 14.9 0.0 0.021 14.3 0.0 1.3 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family Asn_synthase PF00733.21 CAV19427.1 - 5.6e-99 332.2 0.1 1.1e-55 189.8 0.1 2.1 1 1 1 2 2 2 2 Asparagine synthase GATase_7 PF13537.6 CAV19427.1 - 3.7e-41 139.9 0.0 7.1e-41 139.0 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_6 PF13522.6 CAV19427.1 - 3.9e-38 130.7 0.0 6.9e-38 129.9 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase domain DUF3700 PF12481.8 CAV19427.1 - 1.1e-09 38.1 0.0 2.7e-09 36.8 0.0 1.6 1 0 0 1 1 1 1 Aluminium induced protein NAD_synthase PF02540.17 CAV19427.1 - 0.076 12.1 0.0 0.16 11.1 0.0 1.6 1 0 0 1 1 1 0 NAD synthase NusG PF02357.19 CAV19428.1 - 1.1e-21 77.1 0.1 2.1e-21 76.2 0.1 1.4 1 0 0 1 1 1 1 Transcription termination factor nusG PTR2 PF00854.21 CAV19429.1 - 1.3e-57 195.4 18.2 6.9e-30 104.2 4.0 2.1 1 1 1 2 2 2 2 POT family MFS_1 PF07690.16 CAV19429.1 - 6.8e-26 91.0 45.8 4.2e-24 85.1 23.2 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 CAV19429.1 - 0.00021 20.3 31.9 0.027 13.3 4.2 3.5 2 2 1 3 3 3 3 Sugar (and other) transporter EbsA PF17255.2 CAV19429.1 - 0.24 11.7 0.8 24 5.3 0.1 2.4 2 0 0 2 2 2 0 EbsA-like protein Popeye PF04831.13 CAV19429.1 - 1.9 8.7 4.2 20 5.4 0.0 3.5 3 0 0 3 3 3 0 Popeye protein conserved region Ferrochelatase PF00762.19 CAV19430.1 - 6.8e-109 363.8 0.0 8.3e-109 363.5 0.0 1.0 1 0 0 1 1 1 1 Ferrochelatase CbiX PF01903.17 CAV19430.1 - 5.7e-06 26.6 0.0 0.00073 19.8 0.0 2.4 2 0 0 2 2 2 2 CbiX ADK PF00406.22 CAV19431.1 - 1.3e-58 197.4 0.0 1.6e-58 197.1 0.0 1.0 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 CAV19431.1 - 1.7e-26 93.2 0.1 5e-26 91.7 0.0 1.7 2 0 0 2 2 2 1 AAA domain ADK_lid PF05191.14 CAV19431.1 - 3.8e-15 55.6 0.0 7.2e-15 54.7 0.0 1.5 1 0 0 1 1 1 1 Adenylate kinase, active site lid Hydin_ADK PF17213.3 CAV19431.1 - 0.00021 21.6 1.0 0.42 10.9 0.3 2.2 1 1 1 2 2 2 2 Hydin Adenylate kinase-like domain AAA_18 PF13238.6 CAV19431.1 - 0.0063 17.1 0.0 0.016 15.7 0.0 1.8 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.6 CAV19431.1 - 0.014 15.5 0.0 0.12 12.6 0.0 2.1 1 1 0 1 1 1 0 AAA domain AAA_28 PF13521.6 CAV19431.1 - 0.051 13.8 0.0 0.17 12.1 0.0 1.8 2 0 0 2 2 2 0 AAA domain HSP90 PF00183.18 CAV19432.1 - 1.3e-130 436.8 6.7 1e-127 427.2 6.6 2.1 1 1 1 2 2 2 2 Hsp90 protein HATPase_c_3 PF13589.6 CAV19432.1 - 7.9e-13 48.4 0.3 2.2e-12 47.0 0.3 1.8 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 CAV19432.1 - 3.3e-12 46.9 0.1 6.5e-12 46.0 0.1 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Trans_reg_C PF00486.28 CAV19433.1 - 1.4e-19 69.9 0.0 2.8e-19 68.9 0.0 1.5 1 0 0 1 1 1 1 Transcriptional regulatory protein, C terminal ToxS PF17323.2 CAV19434.1 - 3.7e-70 234.4 1.7 4.2e-70 234.1 1.7 1.0 1 0 0 1 1 1 1 Trans-membrane regulatory protein ToxS Baculo_LEF-2 PF03041.14 CAV19434.1 - 0.11 12.1 0.0 0.16 11.6 0.0 1.2 1 0 0 1 1 1 0 lef-2 Rdx PF10262.9 CAV19435.1 - 2.5e-30 104.5 0.2 2.9e-30 104.3 0.2 1.1 1 0 0 1 1 1 1 Rdx family Metallophos_2 PF12850.7 CAV19436.1 - 4.5e-24 85.5 0.0 5.7e-24 85.2 0.0 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Metallophos PF00149.28 CAV19436.1 - 3.7e-10 40.7 0.5 3.4e-09 37.5 0.4 1.9 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase CBS PF00571.28 CAV19437.1 - 1.8e-14 53.9 3.7 9.4e-09 35.6 0.1 2.1 2 0 0 2 2 2 2 CBS domain DUF1694 PF07997.11 CAV19437.1 - 0.0029 17.7 0.1 0.0047 17.0 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1694) CDC48_N PF02359.18 CAV19437.1 - 0.058 13.6 1.1 0.076 13.2 0.2 1.8 2 0 0 2 2 2 0 Cell division protein 48 (CDC48), N-terminal domain P-II PF00543.22 CAV19438.1 - 0.0047 17.5 1.1 0.0061 17.1 1.1 1.2 1 0 0 1 1 1 1 Nitrogen regulatory protein P-II DUF1538 PF07556.11 CAV19439.1 - 2.8e-70 235.9 19.6 3.3e-70 235.7 19.6 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1538) DUF1538 PF07556.11 CAV19440.1 - 1.5e-72 243.3 23.2 1.8e-72 243.1 23.2 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1538) Epimerase PF01370.21 CAV19441.1 - 1.1e-22 80.7 0.0 1.4e-22 80.4 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family DUF1731 PF08338.11 CAV19441.1 - 4.3e-13 48.9 0.0 7.4e-13 48.1 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1731) GDP_Man_Dehyd PF16363.5 CAV19441.1 - 5.8e-10 39.1 0.0 3.7e-09 36.4 0.0 2.0 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase RmlD_sub_bind PF04321.17 CAV19441.1 - 1.2e-05 24.6 0.0 3.3e-05 23.1 0.0 1.7 1 1 0 1 1 1 1 RmlD substrate binding domain NAD_binding_4 PF07993.12 CAV19441.1 - 0.0028 16.8 0.0 0.025 13.8 0.0 2.1 1 1 1 2 2 2 1 Male sterility protein NAD_binding_10 PF13460.6 CAV19441.1 - 0.0036 17.2 0.0 0.0046 16.9 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding Polysacc_synt_2 PF02719.15 CAV19441.1 - 0.0084 15.3 0.0 0.081 12.0 0.0 2.0 2 0 0 2 2 2 1 Polysaccharide biosynthesis protein adh_short PF00106.25 CAV19441.1 - 0.076 12.5 0.0 0.12 11.8 0.0 1.3 1 0 0 1 1 1 0 short chain dehydrogenase Ldh_1_N PF00056.23 CAV19441.1 - 0.13 12.3 0.0 0.22 11.6 0.0 1.4 1 0 0 1 1 1 0 lactate/malate dehydrogenase, NAD binding domain adh_short PF00106.25 CAV19442.1 - 1.6e-39 135.4 0.0 2.2e-39 135.0 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CAV19442.1 - 3.5e-27 95.5 0.0 4.4e-27 95.1 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase NAD_binding_10 PF13460.6 CAV19442.1 - 5e-06 26.5 0.0 7.7e-06 25.9 0.0 1.6 1 1 0 1 1 1 1 NAD(P)H-binding KR PF08659.10 CAV19442.1 - 1.4e-05 25.1 0.0 2.4e-05 24.3 0.0 1.3 1 0 0 1 1 1 1 KR domain NmrA PF05368.13 CAV19442.1 - 1.5e-05 24.7 0.0 2.3e-05 24.1 0.0 1.2 1 0 0 1 1 1 1 NmrA-like family DUF1776 PF08643.10 CAV19442.1 - 2.1e-05 24.0 0.0 0.00081 18.8 0.0 2.0 2 0 0 2 2 2 1 Fungal family of unknown function (DUF1776) Epimerase PF01370.21 CAV19442.1 - 0.0007 19.1 0.0 0.0023 17.4 0.0 1.8 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family TrkA_N PF02254.18 CAV19442.1 - 0.0033 17.6 0.0 0.0055 17.0 0.0 1.3 1 0 0 1 1 1 1 TrkA-N domain Glyco_trans_4_2 PF13477.6 CAV19442.1 - 0.022 14.8 0.0 0.053 13.5 0.0 1.6 2 0 0 2 2 2 0 Glycosyl transferase 4-like ApbA PF02558.16 CAV19442.1 - 0.068 12.8 0.1 0.2 11.3 0.0 1.8 2 0 0 2 2 2 0 Ketopantoate reductase PanE/ApbA RmlD_sub_bind PF04321.17 CAV19442.1 - 0.14 11.2 0.0 0.21 10.7 0.0 1.2 1 0 0 1 1 1 0 RmlD substrate binding domain TPR_20 PF14561.6 CAV19443.1 - 2.7e-29 101.3 1.0 2.7e-29 101.3 1.0 2.8 2 1 0 3 3 3 1 Tetratricopeptide repeat Thioredoxin PF00085.20 CAV19443.1 - 1.3e-15 57.3 0.0 2.3e-15 56.5 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin TPR_19 PF14559.6 CAV19443.1 - 4.5e-14 52.7 14.6 5.9e-11 42.7 4.3 3.0 2 1 1 3 3 3 3 Tetratricopeptide repeat Thioredoxin_6 PF13848.6 CAV19443.1 - 2.6e-05 24.2 0.0 4.7e-05 23.4 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin-like domain HyaE PF07449.11 CAV19443.1 - 4.4e-05 23.4 0.0 8.6e-05 22.5 0.0 1.5 1 0 0 1 1 1 1 Hydrogenase-1 expression protein HyaE Thioredoxin_2 PF13098.6 CAV19443.1 - 0.0078 16.7 0.1 0.02 15.3 0.0 1.8 2 0 0 2 2 1 1 Thioredoxin-like domain TPR_17 PF13431.6 CAV19443.1 - 0.038 14.4 0.3 0.038 14.4 0.3 2.4 3 0 0 3 3 2 0 Tetratricopeptide repeat Thioredoxin_8 PF13905.6 CAV19443.1 - 0.043 14.1 0.0 0.74 10.2 0.0 2.3 1 1 1 2 2 2 0 Thioredoxin-like TraF PF13728.6 CAV19443.1 - 0.1 12.4 1.8 0.12 12.2 0.2 1.9 2 1 0 2 2 2 0 F plasmid transfer operon protein DUF5578 PF17741.1 CAV19443.1 - 0.12 11.8 7.6 1.5 8.1 0.2 3.4 2 1 2 4 4 4 0 Family of unknown function (DUF5578) TPR_2 PF07719.17 CAV19443.1 - 0.62 10.3 6.7 56 4.2 0.4 4.4 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_6 PF13174.6 CAV19443.1 - 0.85 10.4 5.6 8.8 7.2 0.6 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_14 PF13428.6 CAV19443.1 - 0.86 10.6 9.6 15 6.7 0.3 4.3 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_11 PF13414.6 CAV19443.1 - 1 9.1 4.8 0.45 10.2 0.2 2.9 3 1 1 4 4 4 0 TPR repeat TPR_1 PF00515.28 CAV19443.1 - 1.4 8.9 5.1 41 4.2 0.0 4.2 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_16 PF13432.6 CAV19443.1 - 2.3 8.9 6.5 7.4 7.3 2.2 3.0 2 1 0 2 2 2 0 Tetratricopeptide repeat Band_7 PF01145.25 CAV19444.1 - 6.4e-35 120.8 1.4 6.4e-35 120.8 1.4 2.1 1 1 1 2 2 2 1 SPFH domain / Band 7 family Band_7_C PF16200.5 CAV19444.1 - 1.4e-06 28.2 0.6 2.9e-06 27.2 0.6 1.6 1 0 0 1 1 1 1 C-terminal region of band_7 Band_7_1 PF13421.6 CAV19444.1 - 7.5e-05 22.5 0.3 0.00017 21.3 0.3 1.6 1 0 0 1 1 1 1 SPFH domain-Band 7 family DUF2594 PF10769.9 CAV19444.1 - 0.057 13.5 1.2 0.3 11.2 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2594) NfeD PF01957.18 CAV19445.1 - 1.8e-16 60.3 0.0 2.9e-16 59.6 0.0 1.3 1 0 0 1 1 1 1 NfeD-like C-terminal, partner-binding MerR-DNA-bind PF09278.11 CAV19446.1 - 3.2e-14 53.2 0.1 4.9e-14 52.6 0.1 1.3 1 0 0 1 1 1 1 MerR, DNA binding MerR_1 PF13411.6 CAV19446.1 - 4.3e-14 52.4 0.1 1.2e-13 51.0 0.0 1.7 2 0 0 2 2 2 1 MerR HTH family regulatory protein MerR PF00376.23 CAV19446.1 - 1.9e-12 46.7 0.1 3.6e-12 45.8 0.1 1.5 1 0 0 1 1 1 1 MerR family regulatory protein FtsX_ECD PF18075.1 CAV19446.1 - 0.037 14.7 0.0 0.062 13.9 0.0 1.5 1 0 0 1 1 1 0 FtsX extracellular domain DUF3323 PF11796.8 CAV19446.1 - 0.099 12.5 0.0 0.12 12.2 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function N-terminus (DUF3323) DUF2057 PF09829.9 CAV19447.1 - 1.1e-09 38.8 0.5 0.00011 22.5 0.5 2.4 2 0 0 2 2 2 2 Uncharacterized protein conserved in bacteria (DUF2057) Porin_4 PF13609.6 CAV19448.1 - 9.8e-30 104.4 31.1 1.5e-29 103.7 30.7 1.5 1 1 0 1 1 1 1 Gram-negative porin DNA_ligase_aden PF01653.18 CAV19449.1 - 6.6e-132 439.4 0.0 1.3e-131 438.4 0.0 1.5 2 0 0 2 2 2 1 NAD-dependent DNA ligase adenylation domain DNA_ligase_OB PF03120.16 CAV19449.1 - 1.3e-34 117.9 3.1 2.6e-34 116.9 2.1 2.1 2 0 0 2 2 2 1 NAD-dependent DNA ligase OB-fold domain HHH_2 PF12826.7 CAV19449.1 - 2.8e-23 81.8 0.2 1.5e-21 76.2 0.2 2.8 2 0 0 2 2 2 1 Helix-hairpin-helix motif BRCT PF00533.26 CAV19449.1 - 1.6e-12 47.7 0.0 3.2e-12 46.7 0.0 1.6 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain HHH_5 PF14520.6 CAV19449.1 - 6.1e-12 46.0 1.6 5.7e-05 23.6 0.1 3.2 3 0 0 3 3 3 2 Helix-hairpin-helix domain DNA_ligase_ZBD PF03119.16 CAV19449.1 - 1.7e-10 40.7 7.0 4.2e-10 39.4 7.0 1.8 1 0 0 1 1 1 1 NAD-dependent DNA ligase C4 zinc finger domain PTCB-BRCT PF12738.7 CAV19449.1 - 0.0013 18.6 0.0 0.003 17.5 0.0 1.6 1 0 0 1 1 1 1 twin BRCT domain RNA_ligase PF09414.10 CAV19449.1 - 0.0021 18.4 0.0 0.0039 17.5 0.0 1.4 1 0 0 1 1 1 1 RNA ligase HHH PF00633.23 CAV19449.1 - 0.025 14.4 0.0 0.29 11.1 0.0 2.9 2 0 0 2 2 2 0 Helix-hairpin-helix motif Telomere_Sde2_2 PF13297.6 CAV19449.1 - 0.048 13.3 0.1 0.22 11.2 0.1 2.1 1 0 0 1 1 1 0 Telomere stability C-terminal 5_3_exonuc PF01367.20 CAV19449.1 - 0.12 12.9 0.0 0.47 11.1 0.0 2.0 1 0 0 1 1 1 0 5'-3' exonuclease, C-terminal SAM fold ZipA_C PF04354.13 CAV19450.1 - 1.5e-42 144.5 0.0 2.2e-42 144.0 0.0 1.2 1 0 0 1 1 1 1 ZipA, C-terminal FtsZ-binding domain Multi_ubiq PF14452.6 CAV19450.1 - 0.01 16.1 0.0 0.024 14.9 0.0 1.6 1 0 0 1 1 1 0 Multiubiquitin EI24 PF07264.11 CAV19451.1 - 7.5e-39 133.8 15.5 9e-39 133.5 15.5 1.0 1 0 0 1 1 1 1 Etoposide-induced protein 2.4 (EI24) Death_2 PF14786.6 CAV19451.1 - 0.083 12.8 0.1 0.15 12.0 0.1 1.3 1 0 0 1 1 1 0 Tube Death domain PALP PF00291.25 CAV19452.1 - 6.4e-68 229.3 0.9 7.3e-68 229.1 0.9 1.0 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme ADH_zinc_N PF00107.26 CAV19452.1 - 0.037 14.0 0.2 1.1 9.2 0.1 2.8 2 1 0 2 2 2 0 Zinc-binding dehydrogenase PG_isomerase_N PF18353.1 CAV19452.1 - 0.04 14.3 0.1 2.2 8.7 0.1 2.4 1 1 0 1 1 1 0 Phosphoglucose isomerase N-terminal domain DFP PF04127.15 CAV19452.1 - 0.083 12.7 0.2 0.46 10.3 0.1 2.0 2 0 0 2 2 2 0 DNA / pantothenate metabolism flavoprotein PTS-HPr PF00381.19 CAV19453.1 - 1.6e-27 95.5 0.2 1.7e-27 95.4 0.2 1.0 1 0 0 1 1 1 1 PTS HPr component phosphorylation site PEP-utilizers_C PF02896.18 CAV19454.1 - 2.4e-121 404.4 0.0 4.3e-121 403.5 0.0 1.4 1 0 0 1 1 1 1 PEP-utilising enzyme, TIM barrel domain PEP-utilisers_N PF05524.13 CAV19454.1 - 8.1e-31 106.6 7.0 1.2e-30 106.0 2.9 2.6 2 0 0 2 2 2 1 PEP-utilising enzyme, N-terminal PEP-utilizers PF00391.23 CAV19454.1 - 1.3e-20 72.8 0.0 3.6e-20 71.4 0.0 1.8 1 0 0 1 1 1 1 PEP-utilising enzyme, mobile domain HpcH_HpaI PF03328.14 CAV19454.1 - 8.7e-05 21.8 0.0 0.00016 20.9 0.0 1.4 1 0 0 1 1 1 1 HpcH/HpaI aldolase/citrate lyase family CHASE7 PF17151.4 CAV19454.1 - 0.00044 19.9 0.2 0.00097 18.8 0.2 1.5 1 0 0 1 1 1 1 Periplasmic sensor domain SecA_SW PF07516.13 CAV19454.1 - 6.7 6.7 8.2 4.3 7.3 4.4 2.1 2 0 0 2 2 2 0 SecA Wing and Scaffold domain PTS_EIIA_1 PF00358.20 CAV19455.1 - 6.5e-49 164.9 2.1 7.8e-49 164.7 2.1 1.1 1 0 0 1 1 1 1 phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1 Biotin_lipoyl_2 PF13533.6 CAV19455.1 - 0.0018 18.1 0.1 0.013 15.3 0.0 2.3 2 0 0 2 2 2 1 Biotin-lipoyl like RnfC_N PF13375.6 CAV19455.1 - 0.073 13.0 0.3 2 8.4 0.1 2.9 2 1 1 3 3 3 0 RnfC Barrel sandwich hybrid domain Flagellin_N PF00669.20 CAV19456.1 - 1.2e-41 142.1 18.0 1.2e-41 142.1 18.0 2.7 3 0 0 3 3 3 1 Bacterial flagellin N-terminal helical region Flagellin_C PF00700.21 CAV19456.1 - 1e-26 93.1 2.9 1e-26 93.1 2.9 2.7 4 1 1 5 5 5 1 Bacterial flagellin C-terminal helical region Flagellin_IN PF07196.13 CAV19456.1 - 6.2e-12 45.5 0.2 6.2e-12 45.5 0.2 4.0 5 0 0 5 5 5 1 Flagellin hook IN motif GLTSCR1 PF15249.6 CAV19456.1 - 0.14 12.6 0.6 0.33 11.4 0.1 1.9 2 0 0 2 2 2 0 Conserved region of unknown function on GLTSCR protein Flagellin_N PF00669.20 CAV19457.1 - 6.6e-43 146.2 18.0 6.6e-43 146.2 18.0 3.0 2 1 1 3 3 3 1 Bacterial flagellin N-terminal helical region Flagellin_C PF00700.21 CAV19457.1 - 2.2e-23 82.4 4.4 2.2e-23 82.4 4.4 3.7 3 1 2 5 5 5 1 Bacterial flagellin C-terminal helical region Flagellin_IN PF07196.13 CAV19457.1 - 3.2e-09 36.8 0.1 3.2e-09 36.8 0.1 2.4 3 0 0 3 3 3 1 Flagellin hook IN motif Phytochelatin_C PF09328.10 CAV19457.1 - 0.12 11.7 0.5 1.3 8.3 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF1984) Med10 PF09748.9 CAV19457.1 - 0.18 11.8 2.0 1.5 8.8 0.0 2.8 3 0 0 3 3 3 0 Transcription factor subunit Med10 of Mediator complex DUF2721 PF11026.8 CAV19457.1 - 0.28 11.1 1.4 10 6.0 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2721) SesA PF17107.5 CAV19457.1 - 0.58 10.4 4.1 0.34 11.1 0.4 2.3 3 0 0 3 3 3 0 N-terminal domain on NACHT_NTPase and P-loop NTPases Dyp_perox PF04261.12 CAV19458.1 - 1.3e-86 290.6 0.0 1.8e-86 290.1 0.0 1.2 1 0 0 1 1 1 1 Dyp-type peroxidase family Retrotran_gag_3 PF14244.6 CAV19458.1 - 0.18 11.6 0.0 0.59 10.0 0.0 1.8 2 0 0 2 2 2 0 gag-polypeptide of LTR copia-type DUF2919 PF11143.8 CAV19459.1 - 1.1e-52 178.3 7.7 1.2e-52 178.1 7.7 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2919) DUF2956 PF11169.8 CAV19460.1 - 2.1e-42 143.4 10.1 2.4e-42 143.2 10.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2956) PLDc_N PF13396.6 CAV19460.1 - 0.015 15.3 0.1 0.024 14.6 0.1 1.3 1 0 0 1 1 1 0 Phospholipase_D-nuclease N-terminal DUF2370 PF10176.9 CAV19460.1 - 0.098 12.3 0.9 0.12 12.0 0.9 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF2370) DUF4778 PF16008.5 CAV19460.1 - 0.41 10.7 6.5 0.49 10.4 6.5 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4778) VPS38 PF17649.1 CAV19460.1 - 1.4 7.8 10.3 1.5 7.6 10.3 1.0 1 0 0 1 1 1 0 Vacuolar protein sorting 38 BSP_II PF05432.11 CAV19460.1 - 1.7 8.3 10.7 2 8.0 10.7 1.0 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) DUF4337 PF14235.6 CAV19460.1 - 2.3 8.3 14.0 2.3 8.3 13.2 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4337) Med19 PF10278.9 CAV19460.1 - 9.3 6.1 13.0 11 5.9 13.0 1.1 1 0 0 1 1 1 0 Mediator of RNA pol II transcription subunit 19 DUF4156 PF13698.6 CAV19461.1 - 2.1e-19 69.6 0.0 2.9e-19 69.2 0.0 1.2 1 1 0 1 1 1 1 Domain of unknown function (DUF4156) HTH_43 PF09904.9 CAV19462.1 - 9.9e-38 128.0 0.0 1.1e-37 127.8 0.0 1.0 1 0 0 1 1 1 1 Winged helix-turn helix TrmB PF01978.19 CAV19462.1 - 0.0022 17.8 0.0 0.0031 17.4 0.0 1.2 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB ArsC PF03960.15 CAV19463.1 - 7.8e-19 67.5 0.0 8.4e-19 67.4 0.0 1.1 1 0 0 1 1 1 1 ArsC family Glutaredoxin PF00462.24 CAV19463.1 - 0.003 17.7 0.0 0.0056 16.9 0.0 1.5 1 0 0 1 1 1 1 Glutaredoxin BES1_N PF05687.13 CAV19463.1 - 0.046 14.1 0.0 0.058 13.8 0.0 1.1 1 0 0 1 1 1 0 BES1/BZR1 plant transcription factor, N-terminal Peptidase_M20 PF01546.28 CAV19464.1 - 2.1e-44 151.7 0.1 2.7e-44 151.4 0.1 1.1 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 CAV19464.1 - 2.4e-21 75.7 0.0 5.7e-21 74.5 0.0 1.6 2 0 0 2 2 2 1 Peptidase dimerisation domain VanY PF02557.17 CAV19465.1 - 4e-36 123.7 0.4 5.6e-36 123.3 0.4 1.2 1 0 0 1 1 1 1 D-alanyl-D-alanine carboxypeptidase DUF2897 PF11446.8 CAV19466.1 - 3.8e-20 71.5 1.0 3.8e-20 71.5 1.0 1.5 1 1 1 2 2 2 2 Protein of unknown function (DUF2897) EMC3_TMCO1 PF01956.16 CAV19466.1 - 0.0004 20.2 0.1 0.00042 20.1 0.1 1.1 1 0 0 1 1 1 1 Integral membrane protein EMC3/TMCO1-like ABC2_membrane_2 PF12679.7 CAV19466.1 - 0.00097 18.5 0.0 0.00099 18.5 0.0 1.0 1 0 0 1 1 1 1 ABC-2 family transporter protein UPF0370 PF13980.6 CAV19466.1 - 0.041 13.9 5.8 0.11 12.6 5.8 1.7 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0370) ATP-synt_8 PF00895.20 CAV19466.1 - 0.094 13.2 0.3 0.16 12.5 0.3 1.6 1 1 0 1 1 1 0 ATP synthase protein 8 DUF4051 PF13260.6 CAV19466.1 - 0.11 12.3 0.1 0.22 11.3 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4051) Proton_antipo_M PF00361.20 CAV19466.1 - 0.2 10.8 0.2 0.24 10.6 0.2 1.1 1 0 0 1 1 1 0 Proton-conducting membrane transporter Lig_chan PF00060.26 CAV19466.1 - 0.53 10.1 1.9 0.99 9.2 1.9 1.5 1 1 0 1 1 1 0 Ligand-gated ion channel Lipoprotein_18 PF06804.11 CAV19467.1 - 2.5e-102 342.2 0.0 2.9e-102 342.0 0.0 1.0 1 0 0 1 1 1 1 NlpB/DapX lipoprotein DHDPS PF00701.22 CAV19468.1 - 2e-111 371.3 0.0 2.3e-111 371.1 0.0 1.0 1 0 0 1 1 1 1 Dihydrodipicolinate synthetase family Auxin_BP PF02041.16 CAV19468.1 - 0.087 12.5 0.0 0.15 11.7 0.0 1.3 1 0 0 1 1 1 0 Auxin binding protein ACT_6 PF13740.6 CAV19469.1 - 9e-25 86.5 0.9 2.5e-23 81.9 0.2 2.7 2 1 0 2 2 2 1 ACT domain ACT_4 PF13291.6 CAV19469.1 - 4e-07 30.5 0.3 0.019 15.5 0.1 2.5 2 0 0 2 2 2 2 ACT domain ACT PF01842.25 CAV19469.1 - 3.4e-06 26.7 0.5 0.07 12.9 0.0 2.5 2 1 0 2 2 2 2 ACT domain AhpC-TSA PF00578.21 CAV19470.1 - 1.3e-32 112.4 0.0 1.5e-32 112.1 0.0 1.1 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 CAV19470.1 - 6e-25 87.7 0.0 7.2e-25 87.4 0.0 1.0 1 0 0 1 1 1 1 Redoxin SCO1-SenC PF02630.14 CAV19470.1 - 5.4e-05 23.1 0.0 9.4e-05 22.3 0.0 1.5 1 1 0 1 1 1 1 SCO1/SenC DUF899 PF05988.12 CAV19470.1 - 0.0013 18.3 0.0 0.0015 18.1 0.0 1.1 1 0 0 1 1 1 1 Bacterial protein of unknown function (DUF899) AhpC-TSA_2 PF13911.6 CAV19470.1 - 0.0027 17.8 0.0 0.0036 17.4 0.0 1.3 1 0 0 1 1 1 1 AhpC/TSA antioxidant enzyme Pil1 PF13805.6 CAV19470.1 - 0.053 13.0 0.0 0.068 12.7 0.0 1.1 1 0 0 1 1 1 0 Eisosome component PIL1 GSHPx PF00255.19 CAV19470.1 - 0.057 13.0 0.0 0.11 12.1 0.0 1.4 1 0 0 1 1 1 0 Glutathione peroxidase AI-2E_transport PF01594.16 CAV19471.1 - 1.2e-73 248.1 37.8 1.4e-73 247.9 37.8 1.0 1 0 0 1 1 1 1 AI-2E family transporter TusA PF01206.17 CAV19472.1 - 5.8e-14 51.7 0.0 6.9e-14 51.4 0.0 1.1 1 0 0 1 1 1 1 Sulfurtransferase TusA BsuBI_PstI_RE PF06616.11 CAV19472.1 - 0.072 12.4 0.1 0.081 12.2 0.1 1.1 1 0 0 1 1 1 0 BsuBI/PstI restriction endonuclease domain Peptidase_M48 PF01435.18 CAV19473.1 - 1.1e-28 100.4 0.4 1.6e-28 99.8 0.4 1.2 1 0 0 1 1 1 1 Peptidase family M48 TPR_19 PF14559.6 CAV19473.1 - 3.9e-14 52.9 5.4 7.6e-10 39.2 0.0 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 CAV19473.1 - 3.9e-09 35.9 11.3 0.075 13.2 0.8 5.7 5 1 1 6 6 6 3 Tetratricopeptide repeat TPR_14 PF13428.6 CAV19473.1 - 8.4e-09 35.5 10.1 0.012 16.4 0.0 5.7 4 2 2 6 6 5 2 Tetratricopeptide repeat TPR_16 PF13432.6 CAV19473.1 - 7.2e-08 33.0 1.4 0.008 16.8 0.0 5.0 4 1 1 5 5 5 1 Tetratricopeptide repeat ANAPC3 PF12895.7 CAV19473.1 - 9.1e-07 29.0 0.9 0.00055 20.1 0.2 3.6 2 1 2 4 4 3 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_12 PF13424.6 CAV19473.1 - 8.4e-06 26.0 5.4 0.29 11.4 1.0 4.5 3 1 1 4 4 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 CAV19473.1 - 2.1e-05 24.4 9.5 0.93 9.9 0.1 5.5 4 1 1 5 5 5 2 Tetratricopeptide repeat TPR_1 PF00515.28 CAV19473.1 - 9e-05 22.1 7.7 0.28 11.1 0.5 4.6 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_15 PF13429.6 CAV19473.1 - 9.9e-05 21.7 0.3 9.9e-05 21.7 0.3 3.1 2 1 2 4 4 4 1 Tetratricopeptide repeat TPR_6 PF13174.6 CAV19473.1 - 0.0001 22.7 2.3 26 5.7 0.0 5.2 4 0 0 4 4 4 0 Tetratricopeptide repeat ChAPs PF09295.10 CAV19473.1 - 0.00013 21.2 0.2 0.00021 20.5 0.2 1.3 1 0 0 1 1 1 1 ChAPs (Chs5p-Arf1p-binding proteins) TPR_17 PF13431.6 CAV19473.1 - 0.0013 19.0 10.6 0.0041 17.4 0.2 3.8 3 1 0 3 3 2 1 Tetratricopeptide repeat FAT PF02259.23 CAV19473.1 - 0.0019 17.5 0.9 0.0031 16.8 0.9 1.3 1 0 0 1 1 1 1 FAT domain TPR_7 PF13176.6 CAV19473.1 - 0.0026 17.6 1.8 0.32 11.1 0.7 4.0 5 0 0 5 5 4 1 Tetratricopeptide repeat Aminotran_4 PF01063.19 CAV19473.1 - 0.021 14.7 0.2 0.039 13.8 0.2 1.4 1 0 0 1 1 1 0 Amino-transferase class IV TPR_20 PF14561.6 CAV19473.1 - 0.031 14.6 2.7 0.1 12.9 0.1 2.9 2 1 1 3 3 3 0 Tetratricopeptide repeat DUF4157 PF13699.6 CAV19473.1 - 0.035 14.3 0.5 0.08 13.2 0.5 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4157) DUF4919 PF16266.5 CAV19473.1 - 0.037 14.0 0.1 0.12 12.3 0.1 1.9 2 1 0 2 2 1 0 Domain of unknown function (DUF4919) TPR_9 PF13371.6 CAV19473.1 - 0.045 13.9 1.2 0.85 9.8 0.0 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF2201_N PF13203.6 CAV19473.1 - 0.055 13.1 0.1 0.093 12.3 0.1 1.4 1 0 0 1 1 1 0 Putative metallopeptidase domain DUF2268 PF10026.9 CAV19473.1 - 0.08 12.5 0.1 0.14 11.7 0.1 1.3 1 0 0 1 1 1 0 Predicted Zn-dependent protease (DUF2268) Peptidase_M78 PF06114.13 CAV19473.1 - 0.1 12.6 0.6 0.47 10.4 0.6 2.1 1 1 0 1 1 1 0 IrrE N-terminal-like domain SprT-like PF10263.9 CAV19473.1 - 0.13 12.1 0.5 0.38 10.6 0.5 1.7 1 0 0 1 1 1 0 SprT-like family TPR_11 PF13414.6 CAV19473.1 - 1.1 9.0 8.5 8.3 6.2 0.2 3.6 3 0 0 3 3 3 0 TPR repeat ArsC PF03960.15 CAV19474.1 - 1.8e-16 59.9 0.0 2e-16 59.7 0.0 1.1 1 0 0 1 1 1 1 ArsC family Glutaredoxin PF00462.24 CAV19474.1 - 0.00033 20.8 0.0 0.0047 17.1 0.0 2.1 2 0 0 2 2 2 1 Glutaredoxin DUF1687 PF07955.11 CAV19474.1 - 0.003 18.0 0.0 0.016 15.7 0.0 1.8 1 1 0 1 1 1 1 Protein of unknown function (DUF1687) FMN_red PF03358.15 CAV19475.1 - 4.2e-13 49.3 0.0 6.2e-13 48.8 0.0 1.2 1 0 0 1 1 1 1 NADPH-dependent FMN reductase Flavodoxin_2 PF02525.17 CAV19475.1 - 9.2e-05 22.2 0.0 0.00012 21.8 0.0 1.3 1 0 0 1 1 1 1 Flavodoxin-like fold Flavodoxin_5 PF12724.7 CAV19475.1 - 0.00026 21.3 0.0 0.15 12.3 0.0 2.2 1 1 1 2 2 2 2 Flavodoxin domain Flavodoxin_1 PF00258.25 CAV19475.1 - 0.0034 17.6 0.1 0.01 16.1 0.0 1.8 2 0 0 2 2 2 1 Flavodoxin Flavodoxin_3 PF12641.7 CAV19475.1 - 0.04 13.6 0.0 0.062 13.0 0.0 1.3 1 0 0 1 1 1 0 Flavodoxin domain DUF2069 PF09842.9 CAV19476.1 - 3.7e-33 113.8 9.4 4.3e-33 113.6 9.4 1.0 1 0 0 1 1 1 1 Predicted membrane protein (DUF2069) UbiA PF01040.18 CAV19476.1 - 0.42 9.9 9.3 0.57 9.4 9.3 1.2 1 0 0 1 1 1 0 UbiA prenyltransferase family DUF2066 PF09839.9 CAV19477.1 - 5.7e-69 232.1 2.4 5.7e-69 232.1 2.4 1.5 2 0 0 2 2 2 1 Uncharacterized protein conserved in bacteria (DUF2066) Xan_ur_permease PF00860.20 CAV19478.1 - 4.8e-92 308.6 48.7 4.8e-92 308.6 48.7 1.3 2 0 0 2 2 2 1 Permease family UPRTase PF14681.6 CAV19479.1 - 2.5e-62 210.0 0.0 2.9e-62 209.8 0.0 1.0 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase Pribosyltran PF00156.27 CAV19479.1 - 8.7e-15 54.6 0.3 1.3e-14 54.0 0.3 1.2 1 0 0 1 1 1 1 Phosphoribosyl transferase domain Pribosyl_synth PF14572.6 CAV19479.1 - 0.025 14.6 0.0 0.041 13.9 0.0 1.3 1 0 0 1 1 1 0 Phosphoribosyl synthetase-associated domain AAA_26 PF13500.6 CAV19479.1 - 0.075 12.8 0.1 0.25 11.2 0.0 1.7 2 0 0 2 2 2 0 AAA domain AIRS_C PF02769.22 CAV19480.1 - 9.2e-41 139.6 0.3 1.5e-40 138.9 0.3 1.3 1 0 0 1 1 1 1 AIR synthase related protein, C-terminal domain AIRS PF00586.24 CAV19480.1 - 2.7e-15 56.8 0.5 4.7e-15 56.0 0.5 1.4 1 0 0 1 1 1 1 AIR synthase related protein, N-terminal domain Formyl_trans_N PF00551.19 CAV19481.1 - 1.1e-61 207.7 0.0 1.3e-61 207.5 0.0 1.0 1 0 0 1 1 1 1 Formyl transferase GATase_4 PF13230.6 CAV19482.1 - 4.6e-115 383.2 0.0 5.5e-115 382.9 0.0 1.0 1 0 0 1 1 1 1 Glutamine amidotransferases class-II GATase_6 PF13522.6 CAV19482.1 - 1.8e-07 31.4 0.0 3.6e-07 30.5 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase domain SIS_2 PF13580.6 CAV19483.1 - 1.5e-30 106.0 0.1 2e-30 105.6 0.1 1.1 1 0 0 1 1 1 1 SIS domain SIS PF01380.22 CAV19483.1 - 1.7e-06 27.9 0.0 2.9e-06 27.2 0.0 1.3 1 0 0 1 1 1 1 SIS domain DUF1974 PF09317.11 CAV19484.1 - 9.4e-112 373.2 0.0 1.2e-111 372.8 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF1974) Acyl-CoA_dh_N PF02771.16 CAV19484.1 - 1.2e-16 61.4 0.0 4.1e-16 59.6 0.0 2.0 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_1 PF00441.24 CAV19484.1 - 6.3e-15 55.7 0.0 1.1e-14 54.9 0.0 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 CAV19484.1 - 8.3e-08 32.3 0.0 1.7e-07 31.3 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain DUF5362 PF17319.2 CAV19484.1 - 0.046 13.6 0.3 0.19 11.6 0.4 1.9 2 0 0 2 2 2 0 Family of unknown function (DUF5362) TMEM154 PF15102.6 CAV19485.1 - 0.063 13.2 0.3 0.13 12.2 0.3 1.5 1 1 0 1 1 1 0 TMEM154 protein family DUF2207 PF09972.9 CAV19485.1 - 0.15 10.8 0.1 0.23 10.2 0.1 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) VEGFR-2_TMD PF17988.1 CAV19485.1 - 0.31 10.5 3.4 0.63 9.5 3.4 1.4 1 0 0 1 1 1 0 VEGFR-2 Transmembrane domain RNase_T PF00929.24 CAV19486.1 - 3.1e-36 125.4 0.2 3.9e-36 125.1 0.2 1.1 1 0 0 1 1 1 1 Exonuclease DUF5051 PF16473.5 CAV19486.1 - 2.8e-07 30.7 0.0 5.7e-07 29.7 0.0 1.5 1 1 0 1 1 1 1 3' exoribonuclease, RNase T-like DNA_pol_A_exo1 PF01612.20 CAV19486.1 - 0.012 15.4 0.2 0.26 11.0 0.0 2.2 2 0 0 2 2 2 0 3'-5' exonuclease RNase_H PF00075.24 CAV19487.1 - 1.8e-52 177.3 0.0 2e-52 177.2 0.0 1.0 1 0 0 1 1 1 1 RNase H MLVIN_C PF18697.1 CAV19487.1 - 0.019 15.0 1.2 0.028 14.5 0.8 1.4 1 1 0 1 1 1 0 Murine leukemia virus (MLV) integrase (IN) C-terminal domain rve PF00665.26 CAV19488.1 - 1.8e-26 92.6 0.1 6.2e-26 90.9 0.0 1.8 2 0 0 2 2 2 1 Integrase core domain rve_3 PF13683.6 CAV19488.1 - 2.6e-19 68.8 0.0 5.3e-19 67.8 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain DDE_Tnp_IS240 PF13610.6 CAV19488.1 - 0.0001 22.5 0.2 0.00018 21.7 0.2 1.4 1 0 0 1 1 1 1 DDE domain HTH_21 PF13276.6 CAV19488.1 - 0.015 15.4 1.6 0.043 14.0 1.0 2.1 2 0 0 2 2 2 0 HTH-like domain rve_2 PF13333.6 CAV19488.1 - 0.051 13.7 0.1 0.1 12.8 0.1 1.5 1 0 0 1 1 1 0 Integrase core domain RlmM_FDX PF18125.1 CAV19488.1 - 0.13 12.8 0.0 0.47 11.0 0.0 1.9 1 0 0 1 1 1 0 RlmM ferredoxin-like domain HTH_28 PF13518.6 CAV19489.1 - 9.3e-06 25.7 0.1 2.1e-05 24.6 0.1 1.6 1 0 0 1 1 1 1 Helix-turn-helix domain Sugarporin_N PF11471.8 CAV19489.1 - 0.0042 17.0 2.1 0.0082 16.1 2.1 1.5 1 0 0 1 1 1 1 Maltoporin periplasmic N-terminal extension HTH_Tnp_1 PF01527.20 CAV19489.1 - 0.088 13.1 3.0 0.32 11.3 3.0 1.9 1 1 0 1 1 1 0 Transposase Methyltransf_11 PF08241.12 CAV19490.1 - 2.3e-10 41.0 0.0 4e-10 40.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 CAV19490.1 - 2.6e-05 23.7 0.0 3.8e-05 23.1 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_23 PF13489.6 CAV19490.1 - 6.8e-05 22.8 0.0 9e-05 22.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CAV19490.1 - 7.4e-05 23.4 0.0 0.00014 22.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CAV19490.1 - 0.00058 20.6 0.1 0.0011 19.7 0.1 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CAV19490.1 - 0.00065 19.5 0.0 0.00096 19.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_29 PF03141.16 CAV19490.1 - 0.0088 14.6 0.0 0.011 14.3 0.0 1.1 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase MetW PF07021.12 CAV19490.1 - 0.021 14.4 0.0 0.033 13.8 0.0 1.3 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW HAGH_C PF16123.5 CAV19491.1 - 2e-26 92.3 1.1 2.9e-26 91.8 1.1 1.2 1 0 0 1 1 1 1 Hydroxyacylglutathione hydrolase C-terminus Lactamase_B PF00753.27 CAV19491.1 - 6e-18 65.6 5.6 1.9e-17 63.9 5.6 1.8 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 CAV19491.1 - 5.1e-05 22.9 1.9 0.00014 21.5 1.9 1.7 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 CAV19491.1 - 0.0016 18.3 0.1 0.0027 17.6 0.1 1.4 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_6 PF16661.5 CAV19491.1 - 0.015 14.7 0.0 0.029 13.8 0.0 1.4 1 0 0 1 1 1 0 Metallo-beta-lactamase superfamily domain Dak1 PF02733.17 CAV19491.1 - 0.031 13.2 0.0 0.044 12.7 0.0 1.1 1 0 0 1 1 1 0 Dak1 domain AIRS_C PF02769.22 CAV19491.1 - 0.083 13.0 0.0 0.27 11.3 0.0 1.8 2 0 0 2 2 2 0 AIR synthase related protein, C-terminal domain LysM PF01476.20 CAV19492.1 - 2.9e-38 129.7 10.0 2.2e-12 46.8 0.0 5.0 5 0 0 5 5 5 3 LysM domain SLT PF01464.20 CAV19492.1 - 6e-23 80.7 0.2 3.7e-22 78.2 0.0 2.2 2 1 0 2 2 2 1 Transglycosylase SLT domain MLTD_N PF06474.12 CAV19492.1 - 0.19 12.0 0.2 0.49 10.6 0.2 1.7 1 0 0 1 1 1 0 MltD lipid attachment motif DUF1282 PF06930.12 CAV19493.1 - 9.9e-49 165.4 9.6 1.2e-48 165.2 9.6 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1282) Yip1 PF04893.17 CAV19493.1 - 2.4e-11 43.7 16.4 3.5e-11 43.1 16.3 1.3 1 1 0 1 1 1 1 Yip1 domain Exo_endo_phos PF03372.23 CAV19494.1 - 1.4e-05 24.7 0.4 6.4e-05 22.6 0.4 2.0 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.6 CAV19494.1 - 0.0047 16.7 0.0 0.023 14.6 0.0 2.1 2 0 0 2 2 2 1 Endonuclease-reverse transcriptase P-II PF00543.22 CAV19495.1 - 4.1e-45 152.6 3.4 4.6e-45 152.4 3.4 1.0 1 0 0 1 1 1 1 Nitrogen regulatory protein P-II DUF3240 PF11582.8 CAV19495.1 - 0.032 14.4 0.2 0.31 11.2 0.2 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF3240) Nit_Regul_Hom PF10126.9 CAV19495.1 - 0.079 13.0 0.2 0.11 12.5 0.2 1.3 1 1 0 1 1 1 0 Uncharacterized protein, homolog of nitrogen regulatory protein PII Cytochrom_C PF00034.21 CAV19496.1 - 4.1e-10 40.7 0.8 7e-10 39.9 0.8 1.4 1 1 0 1 1 1 1 Cytochrome c Cytochrome_CBB3 PF13442.6 CAV19496.1 - 1.3e-08 35.0 0.6 1.9e-08 34.5 0.6 1.2 1 0 0 1 1 1 1 Cytochrome C oxidase, cbb3-type, subunit III ATP_bind_3 PF01171.20 CAV19497.1 - 2.7e-56 190.2 0.0 4e-56 189.6 0.0 1.3 1 0 0 1 1 1 1 PP-loop family TilS_C PF11734.8 CAV19497.1 - 2.9e-25 87.5 0.1 1e-24 85.7 0.0 1.9 2 0 0 2 2 2 1 TilS substrate C-terminal domain TilS PF09179.11 CAV19497.1 - 2e-18 66.6 1.1 6.1e-18 65.1 1.1 1.9 1 0 0 1 1 1 1 TilS substrate binding domain QueC PF06508.13 CAV19497.1 - 0.018 14.6 0.0 0.063 12.8 0.0 1.8 2 0 0 2 2 2 0 Queuosine biosynthesis protein QueC tRNA_Me_trans PF03054.16 CAV19497.1 - 0.026 13.3 0.1 0.045 12.5 0.1 1.4 1 0 0 1 1 1 0 tRNA methyl transferase PAPS_reduct PF01507.19 CAV19497.1 - 0.081 13.0 0.0 0.17 11.9 0.0 1.6 2 0 0 2 2 2 0 Phosphoadenosine phosphosulfate reductase family ACCA PF03255.14 CAV19498.1 - 2.5e-62 209.0 0.3 2.5e-62 209.0 0.3 1.5 2 0 0 2 2 2 1 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit Carboxyl_trans PF01039.22 CAV19498.1 - 1.1e-18 67.2 0.1 1.3e-18 66.9 0.1 1.1 1 0 0 1 1 1 1 Carboxyl transferase domain MdcE PF06833.11 CAV19498.1 - 0.0031 17.0 0.1 0.0047 16.4 0.1 1.3 1 0 0 1 1 1 1 Malonate decarboxylase gamma subunit (MdcE) PspA_IM30 PF04012.12 CAV19498.1 - 0.064 12.8 1.1 0.078 12.5 0.1 1.6 2 0 0 2 2 2 0 PspA/IM30 family DNA_pol3_alpha PF07733.12 CAV19499.1 - 4.1e-101 337.9 0.0 8e-101 337.0 0.0 1.5 1 0 0 1 1 1 1 Bacterial DNA polymerase III alpha NTPase domain DNA_pol3_finger PF17657.1 CAV19499.1 - 5.4e-64 214.5 0.0 1.4e-63 213.2 0.0 1.7 2 0 0 2 2 2 1 Bacterial DNA polymerase III alpha subunit finger domain PHP PF02811.19 CAV19499.1 - 5.5e-40 137.4 0.0 1.2e-39 136.3 0.0 1.6 1 0 0 1 1 1 1 PHP domain HHH_6 PF14579.6 CAV19499.1 - 1.5e-24 86.1 0.0 3.2e-24 85.0 0.0 1.6 1 0 0 1 1 1 1 Helix-hairpin-helix motif tRNA_anti-codon PF01336.25 CAV19499.1 - 6.2e-11 42.1 0.0 1.3e-10 41.1 0.0 1.6 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA_anti_2 PF13742.6 CAV19499.1 - 0.068 13.4 0.0 0.18 12.0 0.0 1.7 1 0 0 1 1 1 0 OB-fold nucleic acid binding domain RNase_HII PF01351.18 CAV19500.1 - 8.3e-39 133.5 0.0 9.6e-39 133.3 0.0 1.0 1 0 0 1 1 1 1 Ribonuclease HII LpxB PF02684.15 CAV19501.1 - 7.3e-125 416.7 0.0 8.4e-125 416.5 0.0 1.0 1 0 0 1 1 1 1 Lipid-A-disaccharide synthetase DUF3234 PF11572.8 CAV19501.1 - 0.015 15.5 0.0 2.3 8.4 0.0 2.9 2 1 1 3 3 3 0 Protein of unknown function (DUF3234) Glyco_trans_1_4 PF13692.6 CAV19501.1 - 0.1 13.0 0.1 1.3 9.4 0.0 2.2 2 0 0 2 2 2 0 Glycosyl transferases group 1 Acetyltransf_11 PF13720.6 CAV19502.1 - 3.8e-27 94.6 0.0 6.4e-27 93.8 0.0 1.4 1 0 0 1 1 1 1 Udp N-acetylglucosamine O-acyltransferase; Domain 2 Hexapep PF00132.24 CAV19502.1 - 3.4e-25 86.8 29.1 2e-08 33.6 1.5 5.9 3 2 2 6 6 6 6 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 CAV19502.1 - 0.00033 20.3 0.4 0.00033 20.3 0.4 4.3 4 1 0 4 4 4 2 Hexapeptide repeat of succinyl-transferase Vps5 PF09325.10 CAV19502.1 - 0.04 13.5 0.1 0.055 13.0 0.1 1.1 1 0 0 1 1 1 0 Vps5 C terminal like Bactofilin PF04519.13 CAV19502.1 - 0.57 10.5 9.6 0.3 11.4 1.6 2.5 1 1 0 2 2 2 0 Polymer-forming cytoskeletal FabA PF07977.13 CAV19503.1 - 1.1e-40 138.4 0.0 1.3e-40 138.2 0.0 1.0 1 0 0 1 1 1 1 FabA-like domain 4HBT PF03061.22 CAV19503.1 - 0.0026 18.1 0.0 0.0036 17.6 0.0 1.3 1 0 0 1 1 1 1 Thioesterase superfamily MaoC_dehydratas PF01575.19 CAV19503.1 - 0.018 14.6 0.1 0.04 13.5 0.0 1.6 1 1 1 2 2 2 0 MaoC like domain Hexapep PF00132.24 CAV19504.1 - 4.4e-25 86.4 42.4 2.9e-10 39.5 4.1 5.5 4 1 0 5 5 5 5 Bacterial transferase hexapeptide (six repeats) LpxD PF04613.14 CAV19504.1 - 2.1e-21 75.4 0.1 3.3e-21 74.8 0.1 1.3 1 0 0 1 1 1 1 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD Hexapep_2 PF14602.6 CAV19504.1 - 6.4e-11 41.8 39.9 1.7e-08 34.1 7.5 5.9 5 1 1 6 6 6 4 Hexapeptide repeat of succinyl-transferase OmpH PF03938.14 CAV19505.1 - 3e-21 76.2 18.1 3.7e-21 75.9 18.1 1.1 1 0 0 1 1 1 1 Outer membrane protein (OmpH-like) Hydrolase PF00702.26 CAV19505.1 - 0.0073 16.6 1.3 0.56 10.5 0.3 2.1 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase Methyltransf_12 PF08242.12 CAV19505.1 - 0.018 15.8 0.5 0.32 11.8 0.1 2.3 1 1 0 2 2 2 0 Methyltransferase domain Methyltransf_31 PF13847.6 CAV19505.1 - 0.027 14.3 1.1 0.82 9.4 0.3 2.1 2 0 0 2 2 2 0 Methyltransferase domain DmpG_comm PF07836.11 CAV19505.1 - 0.035 13.6 0.5 0.11 12.1 0.1 2.0 2 0 0 2 2 2 0 DmpG-like communication domain Tox-PLDMTX PF15645.6 CAV19505.1 - 0.06 13.6 0.1 0.18 12.1 0.0 1.8 1 1 0 1 1 1 0 Dermonecrotoxin of the Papain-like fold Sox_N PF12444.8 CAV19505.1 - 0.097 13.8 1.3 0.17 13.0 1.3 1.6 1 1 0 1 1 1 0 Sox developmental protein N terminal DUF4570 PF15134.6 CAV19505.1 - 0.21 11.6 8.6 0.38 10.8 1.5 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4570) Bac_surface_Ag PF01103.23 CAV19506.1 - 1.5e-85 287.6 16.8 1.5e-85 287.6 16.8 1.6 2 0 0 2 2 2 1 Surface antigen POTRA PF07244.15 CAV19506.1 - 6.3e-60 199.7 14.5 2.3e-16 60.1 0.2 5.4 5 0 0 5 5 5 5 Surface antigen variable number repeat POTRA_2 PF08479.11 CAV19506.1 - 3.5e-05 23.6 1.1 16 5.4 0.0 5.5 5 1 0 5 5 5 2 POTRA domain, ShlB-type POTRA_1 PF08478.10 CAV19506.1 - 0.00019 21.6 0.2 8.9 6.7 0.0 3.9 4 0 0 4 4 4 2 POTRA domain, FtsQ-type YqfD PF06898.11 CAV19506.1 - 0.084 11.7 0.1 0.23 10.3 0.0 1.7 2 0 0 2 2 2 0 Putative stage IV sporulation protein YqfD Peptidase_M50 PF02163.22 CAV19507.1 - 1.6e-86 289.7 0.2 1.8e-86 289.5 0.2 1.0 1 0 0 1 1 1 1 Peptidase family M50 PDZ_6 PF17820.1 CAV19507.1 - 8.7e-12 44.7 0.4 1.5e-09 37.5 0.1 2.5 2 0 0 2 2 2 2 PDZ domain PDZ PF00595.24 CAV19507.1 - 6.9e-09 35.9 0.2 2.6e-07 30.9 0.0 2.4 2 0 0 2 2 2 1 PDZ domain PDZ_2 PF13180.6 CAV19507.1 - 3.7e-07 30.4 0.1 2.9e-05 24.3 0.0 2.3 2 0 0 2 2 2 1 PDZ domain Tricorn_PDZ PF14685.6 CAV19507.1 - 0.015 15.2 0.2 1.2 9.2 0.0 2.6 2 0 0 2 2 2 0 Tricorn protease PDZ domain DXPR_C PF13288.6 CAV19508.1 - 2.2e-38 131.1 0.0 3.6e-38 130.4 0.0 1.4 1 0 0 1 1 1 1 DXP reductoisomerase C-terminal domain DXP_redisom_C PF08436.12 CAV19508.1 - 7.6e-38 128.6 0.0 1.8e-37 127.3 0.0 1.7 1 0 0 1 1 1 1 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal domain DXP_reductoisom PF02670.16 CAV19508.1 - 1.6e-26 93.6 0.4 3.7e-26 92.3 0.4 1.7 1 0 0 1 1 1 1 1-deoxy-D-xylulose 5-phosphate reductoisomerase CTP_transf_1 PF01148.20 CAV19509.1 - 3.9e-71 239.9 17.4 4.3e-71 239.8 17.4 1.0 1 0 0 1 1 1 1 Cytidylyltransferase family MNHE PF01899.16 CAV19509.1 - 0.011 15.5 0.3 0.011 15.5 0.3 2.7 2 1 0 2 2 2 0 Na+/H+ ion antiporter subunit DUF5518 PF17647.1 CAV19509.1 - 0.019 15.1 3.4 0.019 15.1 3.4 3.7 2 1 2 4 4 4 0 Family of unknown function (DUF5518) DUF2530 PF10745.9 CAV19509.1 - 2.8 8.2 5.3 9.2 6.6 0.3 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2530) Prenyltransf PF01255.19 CAV19510.1 - 5.6e-81 271.3 0.4 6.4e-81 271.1 0.4 1.0 1 0 0 1 1 1 1 Putative undecaprenyl diphosphate synthase AP_endonuc_2 PF01261.24 CAV19510.1 - 0.0024 17.3 0.0 0.15 11.5 0.0 2.1 1 1 1 2 2 2 2 Xylose isomerase-like TIM barrel Dimeth_Pyl PF09505.10 CAV19510.1 - 0.021 13.4 0.0 0.031 12.8 0.0 1.2 1 0 0 1 1 1 0 Dimethylamine methyltransferase (Dimeth_PyL) Toprim_3 PF13362.6 CAV19510.1 - 0.086 13.2 0.1 1 9.8 0.0 2.2 2 0 0 2 2 2 0 Toprim domain RRF PF01765.19 CAV19511.1 - 2.5e-61 206.4 0.4 2.5e-61 206.4 0.4 1.7 2 0 0 2 2 2 1 Ribosome recycling factor DGF-1_C PF11040.8 CAV19511.1 - 0.0046 16.9 0.5 0.25 11.3 0.3 2.4 2 0 0 2 2 2 2 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus AA_kinase PF00696.28 CAV19512.1 - 2.2e-26 92.9 0.2 2.7e-26 92.7 0.2 1.1 1 0 0 1 1 1 1 Amino acid kinase family EF_TS PF00889.19 CAV19513.1 - 2.6e-60 203.6 5.3 3.9e-60 203.0 5.3 1.2 1 0 0 1 1 1 1 Elongation factor TS Ribosomal_S2 PF00318.20 CAV19514.1 - 1.6e-94 315.1 0.1 1.9e-94 314.9 0.1 1.0 1 0 0 1 1 1 1 Ribosomal protein S2 SBD PF17882.1 CAV19514.1 - 0.049 13.5 0.1 6.5 6.6 0.0 2.3 1 1 1 2 2 2 0 OAA-family lectin sugar binding domain Peptidase_M24 PF00557.24 CAV19515.1 - 1.1e-46 159.2 0.1 7.4e-46 156.5 0.1 1.9 1 1 0 1 1 1 1 Metallopeptidase family M24 GlnD_UR_UTase PF08335.11 CAV19516.1 - 2.3e-35 121.8 0.9 7.5e-35 120.2 0.9 2.0 1 0 0 1 1 1 1 GlnD PII-uridylyltransferase HD PF01966.22 CAV19516.1 - 1.5e-13 51.0 0.3 1.5e-13 51.0 0.3 2.2 3 0 0 3 3 3 1 HD domain ACT PF01842.25 CAV19516.1 - 3.1e-13 49.2 0.5 2.2e-06 27.3 0.0 2.6 2 0 0 2 2 2 2 ACT domain NTP_transf_2 PF01909.23 CAV19516.1 - 3.1e-07 30.6 0.0 2e-06 28.0 0.0 2.3 2 0 0 2 2 2 1 Nucleotidyltransferase domain DUF294 PF03445.13 CAV19516.1 - 0.01 15.6 0.0 0.057 13.2 0.0 2.3 2 0 0 2 2 2 0 Putative nucleotidyltransferase DUF294 AIPR PF10592.9 CAV19516.1 - 0.037 13.6 0.0 0.068 12.8 0.0 1.3 1 0 0 1 1 1 0 AIPR protein Polbeta PF18765.1 CAV19516.1 - 0.079 13.1 0.0 0.27 11.4 0.0 1.9 1 0 0 1 1 1 0 Polymerase beta, Nucleotidyltransferase ACT_4 PF13291.6 CAV19516.1 - 0.086 13.4 0.0 2.2 8.9 0.0 2.4 2 0 0 2 2 2 0 ACT domain DUF3461 PF11944.8 CAV19517.1 - 9.4e-55 184.1 2.6 1e-54 184.0 2.6 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3461) OAF PF14941.6 CAV19517.1 - 0.0086 15.6 0.3 0.011 15.2 0.3 1.1 1 0 0 1 1 1 1 Transcriptional regulator, Out at first ClpB_D2-small PF10431.9 CAV19517.1 - 0.023 14.8 0.3 0.11 12.6 0.0 2.1 2 1 0 2 2 2 0 C-terminal, D2-small domain, of ClpB protein PseudoU_synth_2 PF00849.22 CAV19518.1 - 6.7e-31 107.5 0.0 9.1e-31 107.1 0.0 1.2 1 0 0 1 1 1 1 RNA pseudouridylate synthase DUF2202 PF09968.9 CAV19518.1 - 0.097 12.5 0.0 0.18 11.6 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized protein domain (DUF2202) DUF446 PF04287.12 CAV19519.1 - 8.6e-32 109.1 2.1 9.6e-32 109.0 2.1 1.0 1 0 0 1 1 1 1 tRNA pseudouridine synthase C DUF3549 PF12069.8 CAV19520.1 - 2.7e-135 450.8 2.8 3.1e-135 450.6 2.8 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3549) DUF3563 PF12086.8 CAV19520.1 - 0.037 13.8 0.3 0.19 11.4 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3563) DUF3301 PF11743.8 CAV19521.1 - 1e-30 105.2 1.4 1.1e-30 105.1 1.4 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3301) GPR15L PF15854.5 CAV19521.1 - 0.024 14.9 0.5 0.031 14.5 0.5 1.2 1 0 0 1 1 1 0 G-protein coupled receptor ligand 15 Acetyltransf_3 PF13302.7 CAV19522.1 - 2.2e-15 57.6 0.0 2.6e-15 57.3 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 CAV19522.1 - 4.4e-06 26.9 0.0 5.7e-06 26.5 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family FR47 PF08445.10 CAV19522.1 - 0.00015 21.7 0.0 0.00042 20.2 0.0 1.6 2 0 0 2 2 2 1 FR47-like protein Acetyltransf_8 PF13523.6 CAV19522.1 - 0.0002 21.1 0.0 0.00027 20.7 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain GNAT_acetyltran PF12746.7 CAV19522.1 - 0.0054 16.3 0.0 0.0069 16.0 0.0 1.2 1 0 0 1 1 1 1 GNAT acetyltransferase Acetyltransf_4 PF13420.7 CAV19522.1 - 0.049 13.8 0.0 0.063 13.4 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain KfrA_N PF11740.8 CAV19523.1 - 0.0024 18.5 2.5 0.53 11.0 0.8 2.0 1 1 1 2 2 2 2 Plasmid replication region DNA-binding N-term DUF188 PF02639.14 CAV19524.1 - 1e-48 164.3 0.0 1.2e-48 164.1 0.0 1.0 1 0 0 1 1 1 1 Uncharacterized BCR, YaiI/YqxD family COG1671 DUF421 PF04239.12 CAV19524.1 - 0.081 12.7 0.0 0.12 12.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF421) ABG_transport PF03806.13 CAV19525.1 - 2.1e-226 752.0 31.8 2.4e-226 751.8 31.8 1.0 1 0 0 1 1 1 1 AbgT putative transporter family Na_H_antiporter PF03553.14 CAV19525.1 - 4.5e-08 32.7 14.8 4.5e-08 32.7 14.8 3.3 2 1 1 3 3 3 1 Na+/H+ antiporter family DcuC PF03606.15 CAV19525.1 - 6e-06 25.0 29.8 9.7e-06 24.3 29.8 1.4 1 0 0 1 1 1 1 C4-dicarboxylate anaerobic carrier DUF4141 PF13605.6 CAV19525.1 - 0.065 12.5 2.2 0.17 11.1 0.2 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4141) SCFA_trans PF02667.14 CAV19525.1 - 0.16 11.0 28.3 0.37 9.7 27.0 2.0 1 1 1 2 2 2 0 Short chain fatty acid transporter TMEM132D_C PF15706.5 CAV19525.1 - 3.2 7.6 4.2 48 3.8 1.8 3.0 3 0 0 3 3 3 0 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term Ribosomal_L31 PF01197.18 CAV19526.1 - 6.2e-27 93.6 0.2 7.2e-27 93.4 0.2 1.1 1 0 0 1 1 1 1 Ribosomal protein L31 TrmO PF01980.16 CAV19527.1 - 9.1e-43 145.3 0.0 1.4e-42 144.7 0.0 1.3 1 0 0 1 1 1 1 tRNA-methyltransferase O TrmO_C PF18389.1 CAV19527.1 - 1.9e-20 72.7 0.0 2.8e-20 72.2 0.0 1.2 1 0 0 1 1 1 1 TrmO C-terminal domain tRNA-synt_2b PF00587.25 CAV19528.1 - 3.6e-40 137.8 0.0 6.1e-40 137.1 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) tRNA_edit PF04073.15 CAV19528.1 - 1.3e-25 89.9 0.1 3.3e-25 88.5 0.1 1.8 1 1 0 1 1 1 1 Aminoacyl-tRNA editing domain HGTP_anticodon PF03129.20 CAV19528.1 - 3.1e-22 78.5 1.1 1.7e-21 76.1 0.2 2.3 2 0 0 2 2 2 1 Anticodon binding domain DUF533 PF04391.12 CAV19529.1 - 5.7e-61 205.2 10.1 7.4e-61 204.8 10.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF533) TerB PF05099.13 CAV19529.1 - 0.012 15.6 2.9 0.085 12.8 2.9 2.2 1 1 0 1 1 1 0 Tellurite resistance protein TerB TauE PF01925.19 CAV19529.1 - 0.013 15.2 0.0 0.016 14.9 0.0 1.2 1 0 0 1 1 1 0 Sulfite exporter TauE/SafE FNIP_M PF14637.6 CAV19529.1 - 0.04 13.9 0.2 0.061 13.3 0.2 1.2 1 0 0 1 1 1 0 Folliculin-interacting protein middle domain DUF3754 PF12576.8 CAV19529.1 - 0.11 12.5 0.1 0.9 9.5 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3754) UPF0253 PF06786.12 CAV19530.1 - 1.4e-34 118.2 0.2 1.5e-34 118.1 0.2 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0253) DUF4250 PF14056.6 CAV19531.1 - 2.7e-21 75.2 0.0 3.3e-21 75.0 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4250) SHMT PF00464.19 CAV19533.1 - 1.6e-180 599.9 0.1 1.9e-180 599.7 0.1 1.0 1 0 0 1 1 1 1 Serine hydroxymethyltransferase Aminotran_1_2 PF00155.21 CAV19533.1 - 3.8e-09 36.2 0.0 5.6e-09 35.6 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.21 CAV19533.1 - 5.5e-06 25.9 0.1 1.5e-05 24.4 0.1 1.5 1 1 0 1 1 1 1 Beta-eliminating lyase DegT_DnrJ_EryC1 PF01041.17 CAV19533.1 - 4e-05 23.1 0.2 6.1e-05 22.5 0.2 1.3 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_5 PF00266.19 CAV19533.1 - 0.00061 18.8 0.0 0.001 18.1 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class-V Cys_Met_Meta_PP PF01053.20 CAV19533.1 - 0.026 13.0 0.0 0.058 11.9 0.0 1.4 1 1 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme OKR_DC_1 PF01276.20 CAV19533.1 - 0.079 11.7 0.0 0.13 11.0 0.0 1.4 1 0 0 1 1 1 0 Orn/Lys/Arg decarboxylase, major domain YitT_membrane PF02588.15 CAV19534.1 - 1.3e-34 119.4 15.5 1.5e-34 119.2 15.5 1.0 1 0 0 1 1 1 1 Uncharacterised 5xTM membrane BCR, YitT family COG1284 Trans_reg_C PF00486.28 CAV19535.1 - 7.3e-12 45.2 0.0 1.7e-11 44.1 0.0 1.7 1 0 0 1 1 1 1 Transcriptional regulatory protein, C terminal GramPos_pilinD3 PF16570.5 CAV19536.1 - 0.054 14.2 0.6 0.16 12.7 0.6 1.7 1 0 0 1 1 1 0 Gram-positive pilin backbone subunit 3, Cna-B-like domain Alpha-amylase PF00128.24 CAV19537.1 - 1.8e-126 422.3 4.4 3.1e-126 421.5 4.4 1.3 1 0 0 1 1 1 1 Alpha amylase, catalytic domain Malt_amylase_C PF16657.5 CAV19537.1 - 1.5e-08 34.6 0.0 3.4e-08 33.5 0.0 1.7 1 0 0 1 1 1 1 Maltogenic Amylase, C-terminal domain DUF3459 PF11941.8 CAV19537.1 - 0.00028 21.2 0.0 0.0044 17.3 0.0 2.4 2 0 0 2 2 2 1 Domain of unknown function (DUF3459) hDGE_amylase PF14701.6 CAV19537.1 - 0.0019 17.4 0.0 0.0033 16.6 0.0 1.3 1 0 0 1 1 1 1 Glycogen debranching enzyme, glucanotransferase domain Glyco_hydro_114 PF03537.13 CAV19537.1 - 0.065 12.5 0.2 0.97 8.7 0.1 2.4 1 1 1 2 2 2 0 Glycoside-hydrolase family GH114 PTS_EIIC PF02378.18 CAV19538.1 - 7.6e-32 110.6 28.7 7.6e-32 110.6 28.7 1.5 2 0 0 2 2 2 1 Phosphotransferase system, EIIC PTS_EIIB PF00367.20 CAV19538.1 - 2.7e-15 55.5 0.2 4.8e-15 54.8 0.2 1.4 1 0 0 1 1 1 1 phosphotransferase system, EIIB Peripla_BP_3 PF13377.6 CAV19539.1 - 1.7e-19 70.7 0.0 3.5e-19 69.7 0.0 1.5 1 0 0 1 1 1 1 Periplasmic binding protein-like domain LacI PF00356.21 CAV19539.1 - 5e-19 67.8 0.0 1e-18 66.9 0.0 1.5 1 0 0 1 1 1 1 Bacterial regulatory proteins, lacI family Peripla_BP_1 PF00532.21 CAV19539.1 - 3.5e-12 46.4 0.0 4e-12 46.1 0.0 1.1 1 0 0 1 1 1 1 Periplasmic binding proteins and sugar binding domain of LacI family Peripla_BP_4 PF13407.6 CAV19539.1 - 4.4e-09 36.3 0.0 1.2e-08 34.9 0.0 1.6 2 0 0 2 2 2 1 Periplasmic binding protein domain HTH_3 PF01381.22 CAV19539.1 - 0.0078 16.3 0.0 0.015 15.4 0.0 1.5 1 0 0 1 1 1 1 Helix-turn-helix SpoIIID PF12116.8 CAV19539.1 - 0.0083 16.2 0.1 0.019 15.1 0.1 1.6 1 0 0 1 1 1 1 Stage III sporulation protein D TrmB PF01978.19 CAV19539.1 - 0.016 15.1 0.4 1.5 8.8 0.0 2.7 2 0 0 2 2 2 0 Sugar-specific transcriptional regulator TrmB CbiA PF01656.23 CAV19539.1 - 0.018 15.1 0.6 3.3 7.8 0.0 3.1 3 1 0 3 3 3 0 CobQ/CobB/MinD/ParA nucleotide binding domain MAF_flag10 PF01973.18 CAV19539.1 - 0.019 14.6 0.1 0.033 13.9 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function DUF115 RsgA_GTPase PF03193.16 CAV19539.1 - 0.025 14.5 0.3 7.8 6.4 0.0 2.7 2 1 0 2 2 2 0 RsgA GTPase HTH_7 PF02796.15 CAV19539.1 - 0.042 13.9 0.0 0.12 12.4 0.0 1.9 1 0 0 1 1 1 0 Helix-turn-helix domain of resolvase HTH_31 PF13560.6 CAV19539.1 - 0.047 14.0 0.0 0.24 11.8 0.0 2.1 1 1 1 2 2 2 0 Helix-turn-helix domain DAHP_snth_FXD PF18152.1 CAV19539.1 - 0.079 12.8 0.2 1.8 8.5 0.0 2.8 2 0 0 2 2 2 0 DAHP synthase ferredoxin-like domain HTH_IclR PF09339.10 CAV19539.1 - 0.086 12.7 0.0 0.35 10.7 0.0 2.1 2 0 0 2 2 2 0 IclR helix-turn-helix domain Toprim_3 PF13362.6 CAV19539.1 - 0.088 13.2 0.1 0.27 11.6 0.1 1.9 1 1 1 2 2 2 0 Toprim domain MobB PF03205.14 CAV19539.1 - 0.093 12.6 0.3 0.26 11.2 0.0 1.9 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_18 PF13238.6 CAV19539.1 - 0.15 12.6 0.0 0.39 11.3 0.0 1.8 1 1 0 1 1 1 0 AAA domain HTH_Crp_2 PF13545.6 CAV19539.1 - 0.57 10.2 5.6 1.4 8.9 0.0 3.9 5 0 0 5 5 5 0 Crp-like helix-turn-helix domain MliC PF09864.9 CAV19540.1 - 5.4e-16 58.3 0.0 6.7e-16 58.0 0.0 1.1 1 0 0 1 1 1 1 Membrane-bound lysozyme-inhibitor of c-type lysozyme Hydrolase_like PF13242.6 CAV19541.1 - 4.2e-12 46.0 0.1 6.9e-12 45.3 0.1 1.4 1 0 0 1 1 1 1 HAD-hyrolase-like HAD_2 PF13419.6 CAV19541.1 - 4.3e-09 36.7 0.1 3.8e-06 27.1 0.1 2.1 2 0 0 2 2 2 2 Haloacid dehalogenase-like hydrolase PNK3P PF08645.11 CAV19541.1 - 2.2e-06 27.5 0.0 3.6e-06 26.8 0.0 1.3 1 1 0 1 1 1 1 Polynucleotide kinase 3 phosphatase Hydrolase PF00702.26 CAV19541.1 - 9.8e-06 26.0 0.1 0.00038 20.8 0.1 2.2 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Hydrolase_6 PF13344.6 CAV19541.1 - 0.0004 20.5 0.0 0.0013 18.8 0.0 1.8 2 0 0 2 2 2 1 Haloacid dehalogenase-like hydrolase ABC_tran PF00005.27 CAV19542.1 - 5.8e-35 120.8 0.0 8.9e-35 120.2 0.0 1.3 1 0 0 1 1 1 1 ABC transporter NIL PF09383.10 CAV19542.1 - 4.3e-21 74.5 0.0 9.9e-21 73.4 0.0 1.7 1 0 0 1 1 1 1 NIL domain AAA_21 PF13304.6 CAV19542.1 - 4.9e-08 33.1 1.3 0.00022 21.1 0.1 2.2 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 CAV19542.1 - 4.7e-07 29.5 0.9 1.4e-06 27.9 0.9 1.7 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 CAV19542.1 - 5.3e-05 23.5 0.2 0.00019 21.7 0.2 1.8 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 CAV19542.1 - 0.00044 20.7 0.3 0.0011 19.3 0.3 1.6 1 1 0 1 1 1 1 AAA ATPase domain TniB PF05621.11 CAV19542.1 - 0.0047 16.4 0.1 0.088 12.2 0.1 2.3 2 0 0 2 2 2 1 Bacterial TniB protein RsgA_GTPase PF03193.16 CAV19542.1 - 0.0055 16.6 0.1 0.011 15.6 0.1 1.5 1 0 0 1 1 1 1 RsgA GTPase AAA_29 PF13555.6 CAV19542.1 - 0.0059 16.3 0.0 0.012 15.3 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain ABC_ATPase PF09818.9 CAV19542.1 - 0.008 15.0 0.2 2.9 6.6 0.0 2.2 2 0 0 2 2 2 2 Predicted ATPase of the ABC class SbcCD_C PF13558.6 CAV19542.1 - 0.035 14.3 0.2 0.27 11.5 0.2 2.2 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit AAA_23 PF13476.6 CAV19542.1 - 0.063 13.8 0.1 0.15 12.6 0.1 1.5 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.6 CAV19542.1 - 0.094 12.3 0.1 12 5.4 0.0 2.5 2 0 0 2 2 2 0 AAA domain AAA_30 PF13604.6 CAV19542.1 - 0.15 11.8 0.1 0.86 9.3 0.1 2.0 1 1 0 1 1 1 0 AAA domain Mg_chelatase PF01078.21 CAV19542.1 - 0.18 11.2 0.5 5.6 6.3 0.0 2.5 2 1 0 2 2 2 0 Magnesium chelatase, subunit ChlI BPD_transp_1 PF00528.22 CAV19543.1 - 4.1e-24 85.3 12.7 5.9e-24 84.8 12.7 1.2 1 0 0 1 1 1 1 Binding-protein-dependent transport system inner membrane component Lipoprotein_9 PF03180.14 CAV19544.1 - 4.9e-98 326.9 0.8 5.6e-98 326.8 0.8 1.0 1 0 0 1 1 1 1 NLPA lipoprotein OpuAC PF04069.12 CAV19544.1 - 1.2e-05 25.1 0.2 1.7e-05 24.5 0.2 1.3 1 0 0 1 1 1 1 Substrate binding domain of ABC-type glycine betaine transport system Phosphonate-bd PF12974.7 CAV19544.1 - 0.0025 17.5 0.2 0.0042 16.7 0.2 1.3 1 0 0 1 1 1 1 ABC transporter, phosphonate, periplasmic substrate-binding protein SBP_bac_3 PF00497.20 CAV19544.1 - 0.014 14.9 0.2 0.025 14.0 0.0 1.5 2 0 0 2 2 2 0 Bacterial extracellular solute-binding proteins, family 3 LPAM_2 PF13627.6 CAV19544.1 - 0.055 13.3 1.1 0.099 12.5 1.1 1.5 1 0 0 1 1 1 0 Prokaryotic lipoprotein-attachment site HTH_28 PF13518.6 CAV19545.1 - 0.00018 21.6 0.1 0.0004 20.5 0.1 1.6 1 0 0 1 1 1 1 Helix-turn-helix domain Sugarporin_N PF11471.8 CAV19545.1 - 0.0027 17.6 1.8 0.0044 16.9 1.8 1.3 1 0 0 1 1 1 1 Maltoporin periplasmic N-terminal extension rve PF00665.26 CAV19546.1 - 2.9e-26 92.0 0.0 4.5e-26 91.4 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 CAV19546.1 - 2.2e-19 69.0 0.0 4.1e-19 68.1 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain DDE_Tnp_IS240 PF13610.6 CAV19546.1 - 8.2e-05 22.9 0.2 0.00013 22.2 0.2 1.3 1 0 0 1 1 1 1 DDE domain HTH_21 PF13276.6 CAV19546.1 - 0.023 14.8 2.0 0.067 13.3 1.3 2.1 2 0 0 2 2 2 0 HTH-like domain rve_2 PF13333.6 CAV19546.1 - 0.044 14.0 0.1 0.083 13.1 0.1 1.5 1 0 0 1 1 1 0 Integrase core domain Thg1 PF04446.12 CAV19546.1 - 0.14 12.2 0.1 0.61 10.1 0.0 1.9 2 0 0 2 2 2 0 tRNAHis guanylyltransferase Abhydrolase_6 PF12697.7 CAV19547.1 - 0.023 15.3 0.0 0.037 14.6 0.0 1.4 1 1 0 1 1 1 0 Alpha/beta hydrolase family DUF2310 PF10071.9 CAV19548.1 - 7.6e-111 369.4 0.0 8.6e-111 369.3 0.0 1.0 1 0 0 1 1 1 1 Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310) Zn-ribbon_8 PF09723.10 CAV19548.1 - 0.047 13.8 0.8 1.2 9.3 0.1 2.7 2 0 0 2 2 2 0 Zinc ribbon domain Zn_Tnp_IS1595 PF12760.7 CAV19548.1 - 0.13 12.3 0.3 0.13 12.3 0.3 1.9 2 0 0 2 2 2 0 Transposase zinc-ribbon domain zf-TFIIB PF13453.6 CAV19548.1 - 3.2 7.2 6.7 0.39 10.1 1.0 2.2 1 1 1 2 2 2 0 Transcription factor zinc-finger Syd PF07348.12 CAV19549.1 - 1.1e-69 233.6 0.2 1.3e-69 233.4 0.2 1.0 1 0 0 1 1 1 1 Syd protein (SUKH-2) Gp138_N PF18352.1 CAV19549.1 - 0.11 12.6 0.0 0.19 11.8 0.0 1.3 1 0 0 1 1 1 0 Phage protein Gp138 N-terminal domain QueF_N PF14819.6 CAV19550.1 - 1.7e-49 166.7 0.0 1.2e-48 164.0 0.1 2.0 2 0 0 2 2 2 1 Nitrile reductase, 7-cyano-7-deazaguanine-reductase N-term QueF PF14489.6 CAV19550.1 - 3.9e-34 116.6 0.1 1.3e-26 92.5 0.0 2.2 2 0 0 2 2 2 2 QueF-like protein TPR_12 PF13424.6 CAV19551.1 - 9.4e-13 48.3 24.3 1.1e-05 25.7 0.0 5.6 5 1 0 5 5 5 3 Tetratricopeptide repeat TPR_MalT PF17874.1 CAV19551.1 - 1.8e-09 37.4 12.9 8.4e-05 22.1 3.6 3.4 1 1 1 2 2 2 2 MalT-like TPR region TPR_1 PF00515.28 CAV19551.1 - 4.8e-07 29.3 21.8 0.001 18.8 0.0 7.4 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_2 PF07719.17 CAV19551.1 - 1.1e-06 28.3 29.8 0.74 10.1 0.0 8.6 9 0 0 9 9 9 3 Tetratricopeptide repeat SNAP PF14938.6 CAV19551.1 - 0.00018 21.0 7.1 0.0008 18.9 0.0 3.3 3 1 0 4 4 4 1 Soluble NSF attachment protein, SNAP RPN7 PF10602.9 CAV19551.1 - 0.0012 18.6 9.8 0.022 14.5 0.5 3.5 2 1 1 3 3 3 2 26S proteasome subunit RPN7 TPR_14 PF13428.6 CAV19551.1 - 0.004 17.9 12.0 6.6 7.8 0.0 6.8 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_11 PF13414.6 CAV19551.1 - 0.012 15.3 2.7 1.4 8.7 0.0 3.6 4 0 0 4 4 4 0 TPR repeat FBPase_3 PF01950.16 CAV19551.1 - 0.063 12.4 0.0 0.13 11.4 0.0 1.4 1 0 0 1 1 1 0 Fructose-1,6-bisphosphatase VWA PF00092.28 CAV19551.1 - 0.081 13.2 0.2 8.6 6.6 0.1 2.8 2 0 0 2 2 2 0 von Willebrand factor type A domain TPR_10 PF13374.6 CAV19551.1 - 0.084 12.8 11.3 1.5 8.8 0.5 5.2 5 0 0 5 5 4 0 Tetratricopeptide repeat AAA_assoc PF14363.6 CAV19551.1 - 0.19 12.1 1.4 1.3 9.4 0.1 3.0 2 0 0 2 2 2 0 Domain associated at C-terminal with AAA TPR_6 PF13174.6 CAV19551.1 - 4.8 8.0 8.8 3.4e+02 2.2 0.0 6.1 7 0 0 7 7 6 0 Tetratricopeptide repeat TPR_8 PF13181.6 CAV19551.1 - 9.9 6.7 18.9 16 6.0 0.3 6.4 6 0 0 6 6 5 0 Tetratricopeptide repeat GGDEF PF00990.21 CAV19552.1 - 3.7e-38 130.8 0.8 1.1e-37 129.2 0.1 2.3 2 0 0 2 2 2 1 Diguanylate cyclase, GGDEF domain HD_2 PF12917.7 CAV19552.1 - 0.064 13.0 2.2 4.9 6.9 0.0 3.3 3 0 0 3 3 3 0 HD containing hydrolase-like enzyme GGDEF_2 PF17853.1 CAV19552.1 - 0.11 12.8 0.4 1.2 9.4 0.0 2.9 3 1 1 4 4 4 0 GGDEF-like domain Peptidase_M15_2 PF05951.13 CAV19552.1 - 0.12 12.0 3.6 0.099 12.3 0.8 2.2 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF882) RPW8 PF05659.11 CAV19552.1 - 0.25 11.0 9.7 1.6 8.4 0.3 4.0 3 1 1 4 4 4 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 DUF3412 PF11892.8 CAV19553.1 - 5.6e-58 194.3 0.0 1.2e-57 193.2 0.0 1.6 2 0 0 2 2 2 1 Domain of unknown function (DUF3412) DUF4478 PF14793.6 CAV19553.1 - 6.8e-51 170.7 0.1 1.2e-50 169.9 0.1 1.4 1 0 0 1 1 1 1 Pyrimidine/purine nucleotide 5'-monophosphate nucleosidases Lysine_decarbox PF03641.14 CAV19553.1 - 7.3e-35 119.9 0.1 1.4e-34 119.1 0.1 1.5 1 0 0 1 1 1 1 Possible lysine decarboxylase LDcluster4 PF18306.1 CAV19553.1 - 0.00024 20.7 0.0 0.00056 19.5 0.0 1.6 1 1 0 1 1 1 1 SLOG cluster4 family Glycos_transf_2 PF00535.26 CAV19553.1 - 0.0017 18.2 0.1 0.0081 16.0 0.1 1.9 2 0 0 2 2 2 1 Glycosyl transferase family 2 GPAT_N PF14829.6 CAV19553.1 - 0.073 13.1 0.0 0.22 11.5 0.0 1.7 2 0 0 2 2 2 0 Glycerol-3-phosphate acyltransferase N-terminal 5_3_exonuc_N PF02739.16 CAV19554.1 - 4.5e-31 107.9 0.0 6.2e-31 107.5 0.0 1.1 1 0 0 1 1 1 1 5'-3' exonuclease, N-terminal resolvase-like domain 5_3_exonuc PF01367.20 CAV19554.1 - 5.5e-20 71.8 0.0 1.3e-19 70.6 0.0 1.6 1 0 0 1 1 1 1 5'-3' exonuclease, C-terminal SAM fold HTH_Crp_2 PF13545.6 CAV19554.1 - 0.016 15.2 0.0 0.5 10.4 0.0 2.3 2 0 0 2 2 2 0 Crp-like helix-turn-helix domain HHH_5 PF14520.6 CAV19554.1 - 0.033 14.8 0.0 0.12 13.0 0.0 1.9 1 0 0 1 1 1 0 Helix-hairpin-helix domain HHH_2 PF12826.7 CAV19554.1 - 0.094 12.8 0.0 0.36 10.9 0.0 2.0 2 0 0 2 2 2 0 Helix-hairpin-helix motif NYN_YacP PF05991.11 CAV19554.1 - 0.12 12.3 0.1 16 5.4 0.0 2.3 2 0 0 2 2 2 0 YacP-like NYN domain HHH PF00633.23 CAV19554.1 - 0.16 11.9 0.4 0.37 10.8 0.4 1.6 1 0 0 1 1 1 0 Helix-hairpin-helix motif TonB_dep_Rec PF00593.24 CAV19555.1 - 4.6e-36 125.7 27.8 4.6e-36 125.7 27.8 1.5 2 0 0 2 2 2 1 TonB dependent receptor Plug PF07715.15 CAV19555.1 - 3.2e-18 66.3 1.5 4.2e-18 65.9 0.3 1.8 2 0 0 2 2 2 1 TonB-dependent Receptor Plug Domain RlmM_FDX PF18125.1 CAV19556.1 - 3e-30 104.5 0.3 6.5e-30 103.4 0.3 1.6 1 0 0 1 1 1 1 RlmM ferredoxin-like domain FtsJ PF01728.19 CAV19556.1 - 2.7e-05 24.4 0.0 5.3e-05 23.4 0.0 1.6 1 0 0 1 1 1 1 FtsJ-like methyltransferase DUF423 PF04241.15 CAV19557.1 - 9.5e-30 102.7 5.3 9.5e-30 102.7 5.3 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF423) 7TMR-DISM_7TM PF07695.11 CAV19557.1 - 0.16 11.8 14.7 2.3 8.1 14.5 2.4 1 1 0 1 1 1 0 7TM diverse intracellular signalling ABC2_membrane_5 PF13346.6 CAV19557.1 - 0.24 10.9 10.6 0.3 10.6 10.6 1.1 1 0 0 1 1 1 0 ABC-2 family transporter protein FA_desaturase PF00487.24 CAV19557.1 - 0.38 10.5 4.6 0.46 10.3 4.6 1.1 1 0 0 1 1 1 0 Fatty acid desaturase YdjM PF04307.14 CAV19557.1 - 0.75 9.1 5.5 1.1 8.5 5.5 1.4 1 1 0 1 1 1 0 LexA-binding, inner membrane-associated putative hydrolase 2TM PF13239.6 CAV19557.1 - 1.6 9.1 4.9 0.73 10.2 2.5 1.7 2 0 0 2 2 2 0 2TM domain Abhydrolase_1 PF00561.20 CAV19558.1 - 4.9e-08 32.9 0.0 9.8e-08 31.9 0.0 1.5 1 1 1 2 2 2 1 alpha/beta hydrolase fold DLH PF01738.18 CAV19558.1 - 1.4e-06 28.0 0.0 1.9e-06 27.6 0.0 1.2 1 0 0 1 1 1 1 Dienelactone hydrolase family Abhydrolase_6 PF12697.7 CAV19558.1 - 1.8e-05 25.4 0.0 8.5e-05 23.2 0.0 1.8 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.7 CAV19558.1 - 0.00012 21.9 0.0 0.0003 20.6 0.0 1.8 1 1 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CAV19558.1 - 0.0025 17.1 0.3 0.79 8.9 0.3 2.7 2 1 0 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_3 PF07859.13 CAV19558.1 - 0.0029 17.5 0.0 0.014 15.2 0.0 2.0 1 1 1 2 2 2 1 alpha/beta hydrolase fold SBP_bac_3 PF00497.20 CAV19558.1 - 0.0085 15.5 0.0 0.013 15.0 0.0 1.2 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 UPF0227 PF05728.12 CAV19558.1 - 0.012 15.6 0.0 0.096 12.6 0.0 2.0 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0227) LysR_substrate PF03466.20 CAV19559.1 - 5.8e-38 130.4 0.0 9.4e-38 129.7 0.0 1.3 1 0 0 1 1 1 1 LysR substrate binding domain HTH_1 PF00126.27 CAV19559.1 - 1.6e-20 72.8 3.8 2.9e-20 72.0 3.8 1.5 1 0 0 1 1 1 1 Bacterial regulatory helix-turn-helix protein, lysR family HTH_5 PF01022.20 CAV19559.1 - 0.12 12.2 0.0 0.27 11.1 0.0 1.6 1 0 0 1 1 1 0 Bacterial regulatory protein, arsR family HTH_30 PF13556.6 CAV19559.1 - 0.14 12.0 0.8 0.24 11.2 0.8 1.4 1 0 0 1 1 1 0 PucR C-terminal helix-turn-helix domain IgG_binding_B PF01378.17 CAV19559.1 - 0.14 12.2 0.0 0.3 11.2 0.0 1.5 1 0 0 1 1 1 0 B domain ThiI PF02568.14 CAV19560.1 - 1.6e-68 230.2 0.0 3e-68 229.3 0.0 1.4 1 0 0 1 1 1 1 Thiamine biosynthesis protein (ThiI) THUMP PF02926.17 CAV19560.1 - 1.7e-20 73.6 1.0 1.7e-20 73.6 1.0 2.0 2 0 0 2 2 2 1 THUMP domain QueC PF06508.13 CAV19560.1 - 0.001 18.7 0.1 0.45 10.0 0.0 2.8 2 1 1 3 3 3 2 Queuosine biosynthesis protein QueC Rhodanese PF00581.20 CAV19560.1 - 0.0036 17.8 0.2 0.017 15.7 0.2 2.2 1 1 0 1 1 1 1 Rhodanese-like domain Dor1 PF04124.12 CAV19560.1 - 0.089 11.5 0.6 0.15 10.7 0.6 1.3 1 0 0 1 1 1 0 Dor1-like family NAD_synthase PF02540.17 CAV19560.1 - 0.1 11.7 2.6 0.28 10.3 0.2 2.3 3 0 0 3 3 3 0 NAD synthase MotB_plug PF13677.6 CAV19561.1 - 8.5e-18 63.7 0.1 8.5e-18 63.7 0.1 1.8 2 0 0 2 2 2 1 Membrane MotB of proton-channel complex MotA/MotB OmpA PF00691.20 CAV19561.1 - 9.4e-18 64.4 0.4 1.2e-16 60.9 0.0 2.2 2 0 0 2 2 2 1 OmpA family FlaG PF03646.15 CAV19561.1 - 0.046 13.9 4.9 0.11 12.7 4.9 1.6 1 0 0 1 1 1 0 FlaG protein Rep_4 PF05797.11 CAV19561.1 - 0.14 11.3 3.7 0.22 10.6 3.7 1.2 1 0 0 1 1 1 0 Yeast trans-acting factor (REP1/REP2) DUF3290 PF11694.8 CAV19561.1 - 0.35 10.8 2.7 0.74 9.8 2.7 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3290) MotA_ExbB PF01618.16 CAV19562.1 - 3.3e-26 91.5 0.2 3.3e-26 91.5 0.2 2.0 2 0 0 2 2 2 1 MotA/TolQ/ExbB proton channel family Exonuc_VII_S PF02609.16 CAV19563.1 - 3.7e-19 68.5 0.4 4.7e-19 68.2 0.4 1.1 1 0 0 1 1 1 1 Exonuclease VII small subunit polyprenyl_synt PF00348.17 CAV19564.1 - 1.6e-57 194.5 0.3 1.9e-57 194.2 0.3 1.0 1 0 0 1 1 1 1 Polyprenyl synthetase HetR_C PF18460.1 CAV19564.1 - 0.12 12.3 0.1 0.66 9.9 0.0 2.2 2 0 0 2 2 2 0 Heterocyst differentiation regulator C-terminal Hood domain SQS_PSY PF00494.19 CAV19564.1 - 0.13 11.8 1.0 0.21 11.1 0.1 1.8 2 0 0 2 2 2 0 Squalene/phytoene synthase DXP_synthase_N PF13292.6 CAV19565.1 - 2.2e-121 404.3 0.1 4.4e-121 403.2 0.0 1.6 2 0 0 2 2 2 1 1-deoxy-D-xylulose-5-phosphate synthase Transket_pyr PF02779.24 CAV19565.1 - 4.9e-37 127.3 0.1 1.1e-36 126.1 0.1 1.6 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.20 CAV19565.1 - 3.1e-26 91.7 0.1 8.4e-26 90.3 0.1 1.8 1 0 0 1 1 1 1 Transketolase, C-terminal domain TPP_enzyme_C PF02775.21 CAV19565.1 - 2.6e-07 30.6 0.4 1.1e-05 25.3 0.1 2.9 3 0 0 3 3 3 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain E1_dh PF00676.20 CAV19565.1 - 0.00015 20.8 0.1 0.00027 20.0 0.1 1.3 1 0 0 1 1 1 1 Dehydrogenase E1 component Transketolase_N PF00456.21 CAV19565.1 - 0.00073 18.6 0.1 0.027 13.4 0.2 2.3 2 0 0 2 2 2 1 Transketolase, thiamine diphosphate binding domain PgpA PF04608.13 CAV19566.1 - 2.6e-52 176.6 8.6 3e-52 176.4 8.6 1.0 1 0 0 1 1 1 1 Phosphatidylglycerophosphatase A AIRS PF00586.24 CAV19567.1 - 7.9e-21 74.5 0.2 1.6e-20 73.5 0.2 1.5 1 0 0 1 1 1 1 AIR synthase related protein, N-terminal domain AIRS_C PF02769.22 CAV19567.1 - 1e-10 42.0 0.0 1.5e-10 41.5 0.0 1.2 1 0 0 1 1 1 1 AIR synthase related protein, C-terminal domain NusB PF01029.18 CAV19568.1 - 4.7e-35 120.7 0.1 5.5e-35 120.5 0.1 1.0 1 0 0 1 1 1 1 NusB family DMRL_synthase PF00885.19 CAV19569.1 - 1.2e-56 190.4 0.1 1.5e-56 190.1 0.1 1.1 1 0 0 1 1 1 1 6,7-dimethyl-8-ribityllumazine synthase DHBP_synthase PF00926.19 CAV19570.1 - 1.1e-81 273.0 1.5 1.6e-81 272.4 1.5 1.3 1 0 0 1 1 1 1 3,4-dihydroxy-2-butanone 4-phosphate synthase GTP_cyclohydro2 PF00925.20 CAV19570.1 - 2.4e-40 137.8 0.2 2.5e-39 134.5 0.0 2.1 2 0 0 2 2 2 1 GTP cyclohydrolase II Lum_binding PF00677.17 CAV19571.1 - 1.4e-46 156.4 4.2 8.4e-24 83.4 0.2 2.1 2 0 0 2 2 2 2 Lumazine binding domain PhaC_N PF07167.13 CAV19571.1 - 0.11 12.1 0.0 0.2 11.3 0.0 1.5 1 0 0 1 1 1 0 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus ADH_N PF08240.12 CAV19571.1 - 0.36 10.7 1.7 2.6 8.0 0.6 2.6 2 1 1 3 3 3 0 Alcohol dehydrogenase GroES-like domain RibD_C PF01872.17 CAV19572.1 - 3.6e-50 170.6 0.2 5.9e-50 169.9 0.2 1.3 1 0 0 1 1 1 1 RibD C-terminal domain dCMP_cyt_deam_1 PF00383.23 CAV19572.1 - 6.9e-19 67.6 0.5 1.1e-18 66.9 0.5 1.3 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 CAV19572.1 - 5.7e-10 39.1 0.2 9.9e-10 38.3 0.2 1.4 1 0 0 1 1 1 1 MafB19-like deaminase Inv-AAD PF18785.1 CAV19572.1 - 0.0021 17.9 0.5 0.015 15.2 0.5 2.1 1 1 0 1 1 1 1 Invertebrate-AID/APOBEC-deaminase ATP-cone PF03477.16 CAV19573.1 - 1.1e-16 61.1 0.0 1.6e-16 60.6 0.0 1.2 1 0 0 1 1 1 1 ATP cone domain Lar_restr_allev PF14354.6 CAV19573.1 - 0.033 14.6 0.1 0.05 14.0 0.1 1.3 1 0 0 1 1 1 0 Restriction alleviation protein Lar Aldedh PF00171.22 CAV19574.1 - 4.6e-20 71.6 2.6 6.2e-16 58.0 0.4 2.1 2 0 0 2 2 2 2 Aldehyde dehydrogenase family DUF1487 PF07368.11 CAV19574.1 - 0.038 13.4 0.1 0.076 12.5 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1487) AA_kinase PF00696.28 CAV19575.1 - 6.8e-43 147.0 3.0 1e-42 146.4 3.0 1.3 1 0 0 1 1 1 1 Amino acid kinase family PUA PF01472.20 CAV19575.1 - 3.9e-23 81.2 1.8 1.5e-22 79.3 1.8 2.1 1 0 0 1 1 1 1 PUA domain PUA_3 PF17785.1 CAV19575.1 - 0.00087 19.1 0.3 0.0043 16.8 0.2 2.3 2 1 0 2 2 2 1 PUA-like domain Crl PF07417.12 CAV19576.1 - 1.7e-48 163.6 0.1 1.9e-48 163.4 0.1 1.0 1 0 0 1 1 1 1 Sigma factor-binding transcriptional regulator Crl DUF1100 PF06500.11 CAV19577.1 - 2.7e-31 108.8 0.1 3e-31 108.7 0.1 1.0 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF1100) DUF1100 PF06500.11 CAV19578.1 - 4.1e-179 595.7 1.3 4.6e-179 595.5 1.3 1.0 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF1100) DLH PF01738.18 CAV19578.1 - 0.11 12.0 0.0 0.26 10.8 0.0 1.6 2 0 0 2 2 2 0 Dienelactone hydrolase family Pribosyltran PF00156.27 CAV19579.1 - 1.6e-12 47.2 0.0 1.9e-12 47.0 0.0 1.1 1 0 0 1 1 1 1 Phosphoribosyl transferase domain PK_C PF02887.16 CAV19579.1 - 0.1 12.8 0.0 0.18 12.0 0.0 1.4 1 0 0 1 1 1 0 Pyruvate kinase, alpha/beta domain Xan_ur_permease PF00860.20 CAV19580.1 - 1e-54 185.8 48.0 1.2e-54 185.5 48.0 1.1 1 0 0 1 1 1 1 Permease family DUF2834 PF11196.8 CAV19580.1 - 0.018 15.4 7.4 0.018 15.4 7.4 3.6 3 2 0 3 3 3 0 Protein of unknown function (DUF2834) Peptidase_M20 PF01546.28 CAV19581.1 - 1.2e-20 74.1 0.5 9.1e-20 71.2 0.5 2.0 1 1 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 CAV19581.1 - 8.4e-08 32.1 0.0 2.6e-07 30.5 0.0 1.9 2 0 0 2 2 2 1 Peptidase dimerisation domain Peptidase_M28 PF04389.17 CAV19581.1 - 0.014 15.1 0.1 0.03 14.0 0.1 1.5 1 0 0 1 1 1 0 Peptidase family M28 DUF3332 PF11810.8 CAV19582.1 - 7.1e-41 139.7 0.0 8.6e-41 139.4 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3332) AstE_AspA PF04952.14 CAV19583.1 - 2.8e-66 223.6 0.0 3.3e-66 223.3 0.0 1.0 1 0 0 1 1 1 1 Succinylglutamate desuccinylase / Aspartoacylase family Peptidase_M99 PF17033.5 CAV19583.1 - 0.0038 16.7 0.0 0.006 16.1 0.0 1.2 1 0 0 1 1 1 1 Carboxypeptidase controlling helical cell shape catalytic DUF2817 PF10994.8 CAV19583.1 - 0.0064 15.9 0.0 0.023 14.1 0.0 1.7 1 1 1 2 2 2 1 Protein of unknown function (DUF2817) DUF3622 PF12286.8 CAV19584.1 - 7.9e-35 119.0 7.1 7.9e-35 119.0 7.1 1.4 2 0 0 2 2 2 1 Protein of unknown function (DUF3622) SipA PF09052.10 CAV19584.1 - 0.0087 15.7 0.8 0.0097 15.5 0.8 1.0 1 0 0 1 1 1 1 SipA N-terminal domain NnrS PF05940.12 CAV19585.1 - 2.6e-105 352.8 60.5 3e-105 352.6 60.5 1.0 1 0 0 1 1 1 1 NnrS protein Otopetrin PF03189.13 CAV19585.1 - 0.08 11.8 0.1 0.08 11.8 0.1 1.9 2 0 0 2 2 2 0 Otopetrin GGACT PF06094.12 CAV19586.1 - 2.5e-08 34.5 0.0 6.9e-08 33.1 0.0 1.7 1 1 0 2 2 2 1 Gamma-glutamyl cyclotransferase, AIG2-like ChaC PF04752.12 CAV19586.1 - 0.012 15.6 0.1 0.04 14.0 0.1 1.7 1 1 0 1 1 1 0 ChaC-like protein Anthrax_toxA PF03497.16 CAV19587.1 - 1.7e-71 240.0 0.0 3e-71 239.2 0.0 1.4 1 0 0 1 1 1 1 Anthrax toxin LF subunit LysR_substrate PF03466.20 CAV19588.1 - 3.1e-21 75.7 0.0 4.2e-21 75.3 0.0 1.2 1 0 0 1 1 1 1 LysR substrate binding domain HTH_1 PF00126.27 CAV19588.1 - 5.7e-16 58.2 0.0 1.4e-15 57.0 0.0 1.7 1 0 0 1 1 1 1 Bacterial regulatory helix-turn-helix protein, lysR family Peptidase_M9_N PF08453.10 CAV19588.1 - 0.016 14.9 0.1 0.034 13.9 0.1 1.5 1 0 0 1 1 1 0 Peptidase family M9 N-terminal HTH_30 PF13556.6 CAV19588.1 - 0.11 12.3 0.0 0.22 11.4 0.0 1.5 1 0 0 1 1 1 0 PucR C-terminal helix-turn-helix domain Chromate_transp PF02417.15 CAV19589.1 - 1.8e-64 216.6 44.9 1e-32 113.5 15.9 2.2 2 0 0 2 2 2 2 Chromate transporter Pox_A14 PF05767.12 CAV19589.1 - 0.48 10.6 7.2 1.6 8.9 0.2 3.1 1 1 1 2 2 2 0 Poxvirus virion envelope protein A14 Methyltransf_11 PF08241.12 CAV19590.1 - 2e-19 70.0 0.0 3.1e-19 69.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CAV19590.1 - 1.1e-16 61.3 0.0 1.7e-16 60.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CAV19590.1 - 1.7e-14 54.4 0.0 4.9e-14 52.9 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 CAV19590.1 - 7.8e-12 45.3 0.0 1e-11 45.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CAV19590.1 - 9.2e-12 45.0 0.0 1.7e-11 44.1 0.0 1.3 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 CAV19590.1 - 2.5e-10 40.1 0.0 3.3e-10 39.7 0.0 1.1 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family DREV PF05219.12 CAV19590.1 - 8.5e-06 25.1 0.0 1.1e-05 24.7 0.0 1.1 1 0 0 1 1 1 1 DREV methyltransferase MetW PF07021.12 CAV19590.1 - 0.00012 21.7 0.0 0.00028 20.5 0.0 1.5 1 1 0 1 1 1 1 Methionine biosynthesis protein MetW DUF938 PF06080.12 CAV19590.1 - 0.00075 19.3 0.0 0.0012 18.6 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF938) UPF0020 PF01170.18 CAV19590.1 - 0.023 14.4 0.0 0.088 12.5 0.0 1.8 2 0 0 2 2 2 0 Putative RNA methylase family UPF0020 CMAS PF02353.20 CAV19590.1 - 0.057 12.7 0.0 0.077 12.3 0.0 1.2 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Rsm22 PF09243.10 CAV19590.1 - 0.11 11.7 0.0 0.34 10.1 0.0 1.7 1 1 1 2 2 2 0 Mitochondrial small ribosomal subunit Rsm22 Glycos_transf_2 PF00535.26 CAV19591.1 - 2.3e-14 53.6 0.0 3.1e-14 53.1 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 CAV19591.1 - 5.8e-07 29.6 0.0 1.1e-06 28.7 0.0 1.4 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_4 PF13704.6 CAV19591.1 - 0.0077 16.7 0.0 0.014 15.9 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferase family 2 TPR_1 PF00515.28 CAV19593.1 - 4.2e-28 96.0 8.6 5.4e-07 29.2 0.7 6.5 6 0 0 6 6 6 6 Tetratricopeptide repeat TPR_2 PF07719.17 CAV19593.1 - 3.3e-27 92.4 5.5 3.8e-06 26.6 0.3 7.3 7 0 0 7 7 7 5 Tetratricopeptide repeat TPR_8 PF13181.6 CAV19593.1 - 9.5e-22 75.3 5.6 0.002 18.2 0.0 6.5 6 0 0 6 6 6 6 Tetratricopeptide repeat TPR_12 PF13424.6 CAV19593.1 - 1.4e-15 57.4 6.9 0.009 16.3 1.8 5.8 3 2 2 5 5 5 4 Tetratricopeptide repeat TPR_17 PF13431.6 CAV19593.1 - 3.8e-15 55.1 3.1 0.0016 18.7 0.2 5.5 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_16 PF13432.6 CAV19593.1 - 4e-13 49.8 0.3 0.0025 18.4 0.0 5.1 3 1 2 5 5 5 4 Tetratricopeptide repeat TPR_14 PF13428.6 CAV19593.1 - 5.4e-13 48.6 0.1 0.021 15.6 0.0 5.0 4 1 2 6 6 5 3 Tetratricopeptide repeat TPR_19 PF14559.6 CAV19593.1 - 3.3e-12 46.7 6.7 1.1e-06 29.0 0.5 4.3 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_10 PF13374.6 CAV19593.1 - 5.2e-10 38.9 3.8 0.024 14.5 0.0 6.0 5 1 1 6 6 6 2 Tetratricopeptide repeat TPR_7 PF13176.6 CAV19593.1 - 1.1e-09 37.6 5.3 0.26 11.4 0.0 6.3 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_11 PF13414.6 CAV19593.1 - 7.3e-09 35.2 15.6 0.015 15.0 0.1 5.2 4 1 1 5 5 5 3 TPR repeat ANAPC3 PF12895.7 CAV19593.1 - 9.8e-08 32.1 5.8 0.00029 21.0 2.3 3.5 2 1 1 3 3 3 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.6 CAV19593.1 - 2.1e-06 28.0 5.7 0.065 13.9 0.3 5.4 6 0 0 6 6 5 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 CAV19593.1 - 2.4e-05 24.3 2.4 4.6e-05 23.4 0.9 2.4 2 0 0 2 2 2 1 Fis1 C-terminal tetratricopeptide repeat EST1_DNA_bind PF10373.9 CAV19593.1 - 0.0011 18.5 0.4 1.6 8.1 0.1 3.3 4 0 0 4 4 4 1 Est1 DNA/RNA binding domain TPR_20 PF14561.6 CAV19593.1 - 0.0019 18.5 2.1 0.031 14.6 0.2 2.9 2 1 1 3 3 3 1 Tetratricopeptide repeat BTAD PF03704.17 CAV19593.1 - 0.012 16.0 0.0 0.042 14.3 0.0 1.9 1 1 1 2 2 2 0 Bacterial transcriptional activator domain UPF0227 PF05728.12 CAV19593.1 - 0.035 14.0 0.0 0.068 13.1 0.0 1.5 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0227) RPN7 PF10602.9 CAV19593.1 - 0.11 12.2 1.4 0.98 9.1 0.1 2.7 1 1 2 3 3 3 0 26S proteasome subunit RPN7 DUF5113 PF17140.4 CAV19593.1 - 0.34 10.7 4.6 10 5.9 0.3 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF5113) T2SSF PF00482.23 CAV19594.1 - 1.1e-21 77.1 0.2 1.1e-21 77.1 0.2 2.6 3 0 0 3 3 3 1 Type II secretion system (T2SS), protein F T2SSF PF00482.23 CAV19595.1 - 1e-16 61.0 0.2 1e-16 61.0 0.2 2.2 3 0 0 3 3 3 1 Type II secretion system (T2SS), protein F Halogen_Hydrol PF10112.9 CAV19595.1 - 0.0072 16.4 0.4 0.044 13.8 0.0 2.2 2 0 0 2 2 2 1 5-bromo-4-chloroindolyl phosphate hydrolysis protein DUF2919 PF11143.8 CAV19595.1 - 0.059 13.7 2.5 0.14 12.5 2.5 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2919) Rsd_AlgQ PF04353.13 CAV19595.1 - 0.062 13.2 0.0 0.58 10.1 0.0 2.1 2 0 0 2 2 2 0 Regulator of RNA polymerase sigma(70) subunit, Rsd/AlgQ FliG_M PF14841.6 CAV19595.1 - 0.11 12.8 0.2 0.42 10.9 0.0 2.0 2 0 0 2 2 2 0 FliG middle domain Wzy_C PF04932.15 CAV19595.1 - 2.6 7.7 7.6 0.56 9.8 0.9 2.5 2 1 1 3 3 3 0 O-Antigen ligase DUF2207 PF09972.9 CAV19595.1 - 3.6 6.3 5.6 5.4 5.7 1.4 2.4 2 1 0 2 2 2 0 Predicted membrane protein (DUF2207) DUF3784 PF12650.7 CAV19595.1 - 4.3 7.6 9.6 1.1 9.5 2.1 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF3784) T2SSE PF00437.20 CAV19596.1 - 9.5e-83 277.4 0.4 1.3e-82 276.9 0.4 1.2 1 0 0 1 1 1 1 Type II/IV secretion system protein ABC_tran PF00005.27 CAV19596.1 - 0.00065 20.2 0.3 0.0015 19.0 0.0 1.8 2 0 0 2 2 2 1 ABC transporter FtsK_SpoIIIE PF01580.18 CAV19596.1 - 0.0013 18.2 0.5 0.012 14.9 0.0 2.3 2 0 0 2 2 2 1 FtsK/SpoIIIE family Microtub_bd PF16796.5 CAV19596.1 - 0.0079 16.1 0.0 0.018 15.0 0.0 1.7 1 0 0 1 1 1 1 Microtubule binding AAA_16 PF13191.6 CAV19596.1 - 0.0079 16.6 0.3 0.035 14.5 0.0 2.2 2 1 0 2 2 2 1 AAA ATPase domain Mg_chelatase PF01078.21 CAV19596.1 - 0.015 14.7 0.0 0.029 13.8 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI Zeta_toxin PF06414.12 CAV19596.1 - 0.022 14.1 0.0 0.044 13.0 0.0 1.5 1 0 0 1 1 1 0 Zeta toxin AAA_24 PF13479.6 CAV19596.1 - 0.025 14.3 0.3 1.2 8.8 0.0 2.6 3 0 0 3 3 3 0 AAA domain DEAD PF00270.29 CAV19596.1 - 0.046 13.5 0.2 0.18 11.6 0.2 2.1 1 1 0 1 1 1 0 DEAD/DEAH box helicase AAA_28 PF13521.6 CAV19596.1 - 0.049 13.9 0.0 0.14 12.4 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_19 PF13245.6 CAV19596.1 - 0.053 13.8 0.3 0.21 11.9 0.1 2.0 2 0 0 2 2 2 0 AAA domain AAA_30 PF13604.6 CAV19596.1 - 0.061 13.0 0.0 0.18 11.5 0.0 1.7 2 0 0 2 2 2 0 AAA domain AAA_29 PF13555.6 CAV19596.1 - 0.07 12.9 0.3 0.14 11.9 0.3 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_7 PF12775.7 CAV19596.1 - 0.079 12.5 0.0 0.15 11.5 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region Sigma54_activat PF00158.26 CAV19596.1 - 0.079 12.7 0.0 0.15 11.8 0.0 1.5 1 0 0 1 1 1 0 Sigma-54 interaction domain G-alpha PF00503.20 CAV19596.1 - 0.11 11.6 0.1 0.31 10.1 0.0 1.6 2 0 0 2 2 2 0 G-protein alpha subunit AAA_22 PF13401.6 CAV19596.1 - 0.12 12.6 0.1 0.47 10.7 0.0 2.0 2 0 0 2 2 2 0 AAA domain Sigma54_activ_2 PF14532.6 CAV19596.1 - 0.12 12.4 0.0 0.32 11.1 0.0 1.6 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_23 PF13476.6 CAV19596.1 - 0.16 12.4 0.2 0.16 12.4 0.2 2.3 2 0 0 2 2 2 0 AAA domain AAA_31 PF13614.6 CAV19597.1 - 7.5e-11 42.3 0.3 3.2e-10 40.2 0.2 2.1 1 1 0 1 1 1 1 AAA domain CbiA PF01656.23 CAV19597.1 - 1.1e-07 32.0 0.0 1.9e-07 31.2 0.0 1.4 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain ParA PF10609.9 CAV19597.1 - 4.4e-05 23.0 0.0 8.4e-05 22.1 0.0 1.4 1 0 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase ArsA_ATPase PF02374.15 CAV19597.1 - 0.00095 18.4 0.0 0.23 10.6 0.0 2.3 2 0 0 2 2 2 2 Anion-transporting ATPase CBP_BcsQ PF06564.12 CAV19597.1 - 0.0019 17.7 0.1 0.0054 16.2 0.1 1.8 1 1 0 1 1 1 1 Cellulose biosynthesis protein BcsQ TadZ_N PF16968.5 CAV19597.1 - 0.0083 15.8 0.0 0.027 14.2 0.0 1.8 2 0 0 2 2 2 1 Pilus assembly protein TadZ N-terminal TadE PF07811.12 CAV19598.1 - 1.9e-08 34.4 3.7 3e-08 33.8 3.7 1.3 1 0 0 1 1 1 1 TadE-like protein DUF1218 PF06749.12 CAV19598.1 - 0.026 15.0 0.2 0.042 14.4 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1218) TadE PF07811.12 CAV19599.1 - 4.9e-08 33.1 0.2 8.7e-08 32.3 0.2 1.4 1 0 0 1 1 1 1 TadE-like protein Tad PF13400.6 CAV19600.1 - 4.9e-11 42.7 9.6 9.6e-11 41.8 9.6 1.4 1 0 0 1 1 1 1 Putative Flp pilus-assembly TadE/G-like TadF PF16964.5 CAV19600.1 - 0.11 12.2 0.0 0.19 11.5 0.0 1.3 1 0 0 1 1 1 0 Putative tight adherence pilin protein F Secretin PF00263.21 CAV19602.1 - 1.1e-39 135.8 1.1 2.9e-39 134.4 0.1 2.0 2 0 0 2 2 2 1 Bacterial type II and III secretion system protein T2SS-T3SS_pil_N PF13629.6 CAV19602.1 - 5.6e-19 67.6 0.0 1.6e-18 66.2 0.0 1.9 1 0 0 1 1 1 1 Pilus formation protein N terminal region BON PF04972.17 CAV19602.1 - 3.3e-06 27.3 0.0 2.3e-05 24.6 0.0 2.4 2 0 0 2 2 2 1 BON domain RcpC PF16976.5 CAV19603.1 - 5.6e-29 100.5 2.1 1.1e-28 99.6 2.1 1.5 1 0 0 1 1 1 1 Flp pilus assembly protein RcpC/CpaB SAF PF08666.12 CAV19603.1 - 8.6e-10 39.1 0.0 3.6e-09 37.1 0.0 2.0 2 0 0 2 2 2 1 SAF domain ChapFlgA PF13144.6 CAV19603.1 - 9.1e-05 22.5 0.0 0.0002 21.4 0.0 1.6 1 0 0 1 1 1 1 Chaperone for flagella basal body P-ring formation DUF3509 PF12021.8 CAV19603.1 - 0.052 13.3 0.0 0.13 12.0 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3509) AAA_16 PF13191.6 CAV19604.1 - 0.00037 20.9 0.0 0.00066 20.1 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain Torsin PF06309.11 CAV19604.1 - 0.0013 18.9 0.0 0.0026 17.8 0.0 1.5 1 0 0 1 1 1 1 Torsin Mg_chelatase PF01078.21 CAV19604.1 - 0.0025 17.2 0.0 0.0047 16.3 0.0 1.4 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA PF00004.29 CAV19604.1 - 0.0027 18.1 0.0 0.0088 16.5 0.0 1.8 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 CAV19604.1 - 0.0033 17.1 0.0 0.19 11.4 0.0 2.3 2 0 0 2 2 2 1 Sigma-54 interaction domain AAA_7 PF12775.7 CAV19604.1 - 0.0045 16.5 0.0 0.0086 15.6 0.0 1.4 1 0 0 1 1 1 1 P-loop containing dynein motor region PIF1 PF05970.14 CAV19604.1 - 0.0054 15.9 0.0 0.0081 15.4 0.0 1.2 1 0 0 1 1 1 1 PIF1-like helicase AAA_22 PF13401.6 CAV19604.1 - 0.007 16.6 0.0 0.014 15.7 0.0 1.4 1 0 0 1 1 1 1 AAA domain DUF2075 PF09848.9 CAV19604.1 - 0.012 14.9 0.0 0.016 14.5 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_5 PF07728.14 CAV19604.1 - 0.014 15.4 0.0 0.051 13.6 0.0 1.9 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_30 PF13604.6 CAV19604.1 - 0.029 14.1 0.0 0.047 13.4 0.0 1.2 1 0 0 1 1 1 0 AAA domain TIP49 PF06068.13 CAV19604.1 - 0.055 12.7 0.0 0.087 12.0 0.0 1.2 1 0 0 1 1 1 0 TIP49 P-loop domain RNA_helicase PF00910.22 CAV19604.1 - 0.055 13.9 0.0 0.37 11.2 0.0 2.1 2 0 0 2 2 2 0 RNA helicase NACHT PF05729.12 CAV19604.1 - 0.065 13.2 0.0 0.27 11.1 0.0 1.9 2 0 0 2 2 2 0 NACHT domain AAA_11 PF13086.6 CAV19604.1 - 0.074 12.8 0.0 0.12 12.2 0.0 1.2 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.6 CAV19604.1 - 0.092 12.3 0.0 0.17 11.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain TsaE PF02367.17 CAV19604.1 - 0.13 12.3 0.0 0.22 11.5 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE PhoH PF02562.16 CAV19604.1 - 0.14 11.6 0.2 0.79 9.1 0.1 2.3 3 0 0 3 3 3 0 PhoH-like protein AAA_24 PF13479.6 CAV19604.1 - 0.22 11.2 0.0 0.33 10.6 0.0 1.2 1 0 0 1 1 1 0 AAA domain ATPase PF06745.13 CAV19604.1 - 0.23 10.7 0.0 0.37 10.1 0.0 1.2 1 0 0 1 1 1 0 KaiC Peptidase_A24 PF01478.18 CAV19605.1 - 1.7e-12 47.7 12.1 2.9e-12 47.0 12.1 1.4 1 0 0 1 1 1 1 Type IV leader peptidase family B12D PF06522.11 CAV19605.1 - 0.81 9.5 3.3 20 5.0 0.5 2.5 2 0 0 2 2 2 0 NADH-ubiquinone reductase complex 1 MLRQ subunit Ndc1_Nup PF09531.10 CAV19605.1 - 8.1 5.0 7.7 11 4.6 7.7 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Flp_Fap PF04964.14 CAV19606.1 - 4.1e-05 23.3 2.5 5.2e-05 23.0 2.5 1.2 1 0 0 1 1 1 1 Flp/Fap pilin component DUF308 PF03729.13 CAV19606.1 - 0.0031 17.8 0.3 0.0032 17.7 0.3 1.1 1 0 0 1 1 1 1 Short repeat of unknown function (DUF308) YtpI PF14007.6 CAV19606.1 - 0.0045 17.1 0.1 0.0051 16.9 0.1 1.1 1 0 0 1 1 1 1 YtpI-like protein Flp1_like PF16982.5 CAV19606.1 - 0.026 13.9 1.6 0.041 13.3 1.6 1.6 1 1 0 1 1 1 0 Putative Flagellin, Flp1-like, domain SPW PF03779.14 CAV19606.1 - 0.036 13.7 0.9 0.13 11.9 0.5 1.8 1 1 1 2 2 2 0 SPW repeat DUF4225 PF13988.6 CAV19606.1 - 0.1 12.1 0.0 0.1 12.1 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4225) PsbN PF02468.15 CAV19606.1 - 0.19 11.6 0.4 0.22 11.4 0.4 1.1 1 0 0 1 1 1 0 Photosystem II reaction centre N protein (psbN) HTH_AraC PF00165.23 CAV19607.1 - 1.5e-20 72.8 0.9 2.3e-12 46.7 0.1 2.8 3 0 0 3 3 3 2 Bacterial regulatory helix-turn-helix proteins, AraC family HTH_18 PF12833.7 CAV19607.1 - 6.8e-20 71.1 0.1 1e-19 70.5 0.1 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain VRP3 PF03536.15 CAV19607.1 - 0.001 18.7 0.3 0.0014 18.2 0.3 1.2 1 0 0 1 1 1 1 Salmonella virulence-associated 28kDa protein SIS PF01380.22 CAV19607.1 - 0.086 12.7 0.2 0.14 12.0 0.2 1.3 1 0 0 1 1 1 0 SIS domain EutH PF04346.12 CAV19608.1 - 0.079 12.1 0.1 0.079 12.1 0.1 1.0 1 0 0 1 1 1 0 Ethanolamine utilisation protein, EutH AMP-binding PF00501.28 CAV19609.1 - 8.7e-89 298.0 0.0 1e-88 297.8 0.0 1.0 1 0 0 1 1 1 1 AMP-binding enzyme DUF1127 PF06568.11 CAV19610.1 - 2.3e-10 40.0 0.0 3.2e-10 39.6 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF1127) DnaI_N PF07319.11 CAV19610.1 - 0.039 14.6 0.2 0.05 14.3 0.2 1.3 1 1 0 1 1 1 0 Primosomal protein DnaI N-terminus LysR_substrate PF03466.20 CAV19611.1 - 1.1e-24 87.0 0.0 1.5e-24 86.6 0.0 1.2 1 0 0 1 1 1 1 LysR substrate binding domain HTH_1 PF00126.27 CAV19611.1 - 2.6e-19 68.9 0.0 4.8e-19 68.1 0.0 1.5 1 0 0 1 1 1 1 Bacterial regulatory helix-turn-helix protein, lysR family HTH_30 PF13556.6 CAV19611.1 - 0.026 14.3 0.0 0.05 13.4 0.0 1.4 1 0 0 1 1 1 0 PucR C-terminal helix-turn-helix domain UPF0236 PF06782.11 CAV19611.1 - 0.045 12.4 0.0 0.065 11.9 0.0 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0236) LytTR PF04397.15 CAV19611.1 - 0.1 12.8 0.1 0.52 10.6 0.0 2.1 2 1 1 3 3 3 0 LytTr DNA-binding domain VF530 PF09905.9 CAV19612.1 - 3.4e-36 123.2 0.1 3.8e-36 123.1 0.1 1.0 1 0 0 1 1 1 1 DNA-binding protein VF530 GTP_EFTU PF00009.27 CAV19613.1 - 7.3e-61 205.1 0.1 1.4e-60 204.2 0.0 1.5 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain EFG_IV PF03764.18 CAV19613.1 - 1.4e-42 144.3 0.1 3.7e-42 142.9 0.1 1.8 1 0 0 1 1 1 1 Elongation factor G, domain IV EFG_II PF14492.6 CAV19613.1 - 2.4e-29 101.3 0.0 5e-29 100.2 0.0 1.6 1 0 0 1 1 1 1 Elongation Factor G, domain II EFG_C PF00679.24 CAV19613.1 - 7.9e-28 96.3 0.0 2.1e-27 94.9 0.0 1.8 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 CAV19613.1 - 2e-15 56.9 0.2 5.5e-15 55.5 0.2 1.8 1 0 0 1 1 1 1 Elongation factor Tu domain 2 AIG1 PF04548.16 CAV19613.1 - 0.0023 17.3 0.0 0.005 16.2 0.0 1.5 1 0 0 1 1 1 1 AIG1 family MMR_HSR1 PF01926.23 CAV19613.1 - 0.0059 16.7 0.0 0.019 15.1 0.0 1.9 1 0 0 1 1 1 1 50S ribosome-binding GTPase CbiX PF01903.17 CAV19613.1 - 0.008 16.5 0.0 0.019 15.3 0.0 1.6 1 0 0 1 1 1 1 CbiX ATPase PF06745.13 CAV19615.1 - 4.6e-16 58.9 0.1 3.5e-09 36.4 0.0 2.3 1 1 1 2 2 2 2 KaiC AAA_25 PF13481.6 CAV19615.1 - 1.4e-14 54.1 0.2 4.3e-14 52.5 0.2 1.8 1 1 0 1 1 1 1 AAA domain Rubredoxin_2 PF18073.1 CAV19615.1 - 1.3e-12 47.2 5.2 2e-12 46.6 5.2 1.3 1 0 0 1 1 1 1 Rubredoxin metal binding domain ChlI PF13541.6 CAV19615.1 - 1e-09 38.3 0.0 2.8e-09 36.8 0.0 1.8 2 0 0 2 2 2 1 Subunit ChlI of Mg-chelatase DnaB_C PF03796.15 CAV19615.1 - 2.1e-08 33.8 0.3 7.5e-05 22.2 0.0 2.2 1 1 1 2 2 2 2 DnaB-like helicase C terminal domain Lon_C PF05362.13 CAV19615.1 - 5.8e-07 29.2 0.8 1.1e-06 28.3 0.2 1.7 2 0 0 2 2 2 1 Lon protease (S16) C-terminal proteolytic domain Rad51 PF08423.11 CAV19615.1 - 2.4e-06 27.0 1.0 0.00053 19.3 1.0 2.2 1 1 0 1 1 1 1 Rad51 GvpD PF07088.11 CAV19615.1 - 8.3e-05 21.4 0.1 0.07 11.7 0.0 2.3 1 1 1 2 2 2 2 GvpD gas vesicle protein DUF2075 PF09848.9 CAV19615.1 - 0.00035 19.9 0.1 0.00054 19.3 0.1 1.2 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) RecA PF00154.21 CAV19615.1 - 0.00037 20.1 0.1 0.00058 19.4 0.1 1.3 1 0 0 1 1 1 1 recA bacterial DNA recombination protein AAA PF00004.29 CAV19615.1 - 0.00039 20.8 0.0 0.00086 19.7 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 CAV19615.1 - 0.0012 19.1 0.0 0.0022 18.2 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_14 PF13173.6 CAV19615.1 - 0.0049 16.9 0.0 0.009 16.0 0.0 1.3 1 0 0 1 1 1 1 AAA domain ABC_tran PF00005.27 CAV19615.1 - 0.0085 16.6 0.0 0.016 15.7 0.0 1.4 1 0 0 1 1 1 1 ABC transporter AAA_16 PF13191.6 CAV19615.1 - 0.011 16.1 0.3 0.043 14.2 0.3 2.1 1 1 0 1 1 1 0 AAA ATPase domain Zeta_toxin PF06414.12 CAV19615.1 - 0.012 15.0 0.5 0.033 13.5 0.2 1.9 1 1 1 2 2 2 0 Zeta toxin NTPase_1 PF03266.15 CAV19615.1 - 0.018 14.9 0.4 0.18 11.7 0.0 2.3 1 1 1 2 2 2 0 NTPase AAA_24 PF13479.6 CAV19615.1 - 0.019 14.7 0.0 0.03 14.0 0.0 1.3 1 0 0 1 1 1 0 AAA domain DUF1258 PF06869.12 CAV19615.1 - 0.029 13.9 0.6 3.4 7.1 0.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1258) Zn-ribbon_8 PF09723.10 CAV19615.1 - 0.044 13.9 0.4 0.093 12.9 0.4 1.5 1 0 0 1 1 1 0 Zinc ribbon domain Viral_helicase1 PF01443.18 CAV19615.1 - 0.077 12.7 0.0 0.12 12.1 0.0 1.3 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase cobW PF02492.19 CAV19615.1 - 0.079 12.5 0.5 0.19 11.3 0.2 1.8 1 1 1 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Usp PF00582.26 CAV19615.1 - 0.086 13.4 0.2 0.88 10.1 0.1 2.2 1 1 1 2 2 2 0 Universal stress protein family AAA_29 PF13555.6 CAV19615.1 - 0.092 12.5 0.1 0.22 11.3 0.1 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain PAXNEB PF05625.11 CAV19615.1 - 0.2 10.8 0.1 0.3 10.2 0.1 1.2 1 0 0 1 1 1 0 PAXNEB protein PilZ PF07238.14 CAV19616.1 - 6.3e-23 81.1 0.0 1.6e-10 41.2 0.0 2.5 2 0 0 2 2 2 2 PilZ domain DUF5609 PF18429.1 CAV19617.1 - 8.7e-23 79.9 0.0 1.9e-22 78.8 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF5609) HAD PF12710.7 CAV19617.1 - 1.2e-16 61.7 0.0 1.5e-13 51.6 0.0 2.2 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 CAV19617.1 - 3.5e-14 53.6 0.1 1.9e-13 51.2 0.2 1.9 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 CAV19617.1 - 1.6e-09 37.9 0.1 3.1e-08 33.7 0.1 2.5 2 1 1 3 3 3 1 haloacid dehalogenase-like hydrolase Put_Phosphatase PF06888.12 CAV19617.1 - 6e-05 22.5 0.0 0.0016 17.9 0.0 2.1 2 0 0 2 2 2 1 Putative Phosphatase HAD_2 PF13419.6 CAV19617.1 - 0.00083 19.5 0.0 0.046 13.8 0.0 2.8 2 1 0 2 2 2 1 Haloacid dehalogenase-like hydrolase S6PP PF05116.13 CAV19617.1 - 0.029 13.9 0.1 0.072 12.6 0.1 1.7 2 0 0 2 2 2 0 Sucrose-6F-phosphate phosphohydrolase SMP_2 PF10144.9 CAV19618.1 - 4.7e-37 127.1 2.7 6.6e-37 126.6 2.7 1.1 1 0 0 1 1 1 1 Bacterial virulence factor haemolysin ID PF18543.1 CAV19618.1 - 0.0033 17.4 0.4 0.0061 16.6 0.4 1.4 1 0 0 1 1 1 1 Intracellular delivery domain Ski_Sno PF02437.17 CAV19618.1 - 0.012 15.4 0.2 0.019 14.7 0.2 1.3 1 0 0 1 1 1 0 SKI/SNO/DAC family sCache_3_2 PF17203.4 CAV19618.1 - 0.02 15.0 0.7 0.15 12.1 0.3 2.5 2 1 0 2 2 2 0 Single cache domain 3 MCM_lid PF17855.1 CAV19618.1 - 0.043 14.2 0.4 0.073 13.5 0.4 1.4 1 0 0 1 1 1 0 MCM AAA-lid domain TraL PF07178.11 CAV19618.1 - 0.05 14.1 1.7 0.14 12.6 0.2 2.1 2 0 0 2 2 2 0 TraL protein Chitin_synth_1 PF01644.17 CAV19618.1 - 0.057 13.4 0.1 0.095 12.7 0.1 1.3 1 0 0 1 1 1 0 Chitin synthase DUF2304 PF10066.9 CAV19618.1 - 0.61 10.3 5.2 0.55 10.5 1.0 2.5 2 1 0 2 2 2 0 Uncharacterized conserved protein (DUF2304) PNP_UDP_1 PF01048.20 CAV19619.1 - 2.8e-41 141.3 2.4 3.3e-41 141.1 2.4 1.0 1 0 0 1 1 1 1 Phosphorylase superfamily YidD PF01809.18 CAV19619.1 - 0.05 13.5 0.5 0.22 11.4 0.0 2.1 2 0 0 2 2 2 0 Putative membrane protein insertion efficiency factor Metalloenzyme PF01676.18 CAV19620.1 - 1e-34 120.0 0.0 1.4e-34 119.6 0.0 1.1 1 0 0 1 1 1 1 Metalloenzyme superfamily Phosphodiest PF01663.22 CAV19620.1 - 0.028 14.0 0.0 0.042 13.4 0.0 1.2 1 0 0 1 1 1 0 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.23 CAV19620.1 - 0.055 12.9 0.1 0.12 11.7 0.0 1.6 2 0 0 2 2 2 0 Sulfatase Glycos_transf_3 PF00591.21 CAV19621.1 - 9.5e-49 166.3 4.8 1.7e-48 165.4 4.8 1.4 1 0 0 1 1 1 1 Glycosyl transferase family, a/b domain PYNP_C PF07831.13 CAV19621.1 - 8e-24 83.1 1.1 1.6e-23 82.1 0.3 2.0 2 0 0 2 2 2 1 Pyrimidine nucleoside phosphorylase C-terminal domain Glycos_trans_3N PF02885.17 CAV19621.1 - 8.1e-21 73.6 0.2 1.8e-20 72.5 0.2 1.6 1 0 0 1 1 1 1 Glycosyl transferase family, helical bundle domain DeoC PF01791.9 CAV19622.1 - 3.3e-47 161.1 2.3 3.6e-47 160.9 2.3 1.0 1 0 0 1 1 1 1 DeoC/LacD family aldolase GRAS PF03514.14 CAV19622.1 - 0.16 10.9 0.0 0.29 10.0 0.0 1.4 2 0 0 2 2 2 0 GRAS domain family Nucleos_tra2_C PF07662.13 CAV19623.1 - 1.3e-74 250.6 6.5 1.3e-74 250.6 6.5 2.5 4 0 0 4 4 4 1 Na+ dependent nucleoside transporter C-terminus Nucleos_tra2_N PF01773.20 CAV19623.1 - 1.7e-25 89.4 2.7 1.7e-25 89.4 2.7 3.1 1 1 0 2 2 2 1 Na+ dependent nucleoside transporter N-terminus Gate PF07670.14 CAV19623.1 - 4.3e-06 27.0 5.0 4.3e-06 27.0 5.0 3.2 2 1 0 2 2 2 1 Nucleoside recognition TatD_DNase PF01026.21 CAV19624.1 - 5.1e-65 219.4 0.0 5.8e-65 219.2 0.0 1.0 1 0 0 1 1 1 1 TatD related DNase SpvD PF05563.12 CAV19624.1 - 0.11 12.1 0.0 0.17 11.5 0.0 1.2 1 0 0 1 1 1 0 Salmonella plasmid virulence protein SpvD DUF5363 PF17320.2 CAV19625.1 - 3.2e-07 30.1 0.3 4e-07 29.8 0.3 1.1 1 0 0 1 1 1 1 Family of unknown function (DUF5363) RF3_C PF16658.5 CAV19626.1 - 2.9e-46 156.5 0.0 5.9e-46 155.5 0.0 1.6 1 0 0 1 1 1 1 Class II release factor RF3, C-terminal domain GTP_EFTU PF00009.27 CAV19626.1 - 6.3e-46 156.4 0.0 9.4e-46 155.8 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D2 PF03144.25 CAV19626.1 - 8.6e-09 35.7 0.1 2.6e-08 34.1 0.1 1.9 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 CAV19626.1 - 9.9e-05 22.4 0.0 0.00023 21.2 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase EFG_II PF14492.6 CAV19626.1 - 0.00019 21.5 0.0 0.00042 20.3 0.0 1.5 1 0 0 1 1 1 1 Elongation Factor G, domain II Ras PF00071.22 CAV19626.1 - 0.1 12.2 0.0 0.19 11.3 0.0 1.3 1 0 0 1 1 1 0 Ras family Acetyltransf_1 PF00583.25 CAV19627.1 - 1.6e-15 57.4 0.0 2e-15 57.1 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 CAV19627.1 - 8.4e-14 51.6 0.0 1e-13 51.3 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 CAV19627.1 - 1e-12 48.3 0.0 1.3e-12 48.0 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 CAV19627.1 - 3.2e-07 30.2 0.0 4.9e-07 29.6 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_4 PF13420.7 CAV19627.1 - 4e-06 27.0 0.0 4.6e-06 26.9 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.7 CAV19627.1 - 4.3e-06 27.5 0.1 6.1e-06 27.0 0.1 1.3 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.6 CAV19627.1 - 6.5e-06 25.9 0.1 0.00038 20.1 0.0 2.1 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 CAV19627.1 - 0.00045 20.3 0.0 0.0029 17.7 0.0 2.0 1 1 1 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 CAV19627.1 - 0.00057 20.0 0.0 0.00099 19.2 0.0 1.3 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase GNAT_acetyltran PF12746.7 CAV19627.1 - 0.038 13.6 0.0 0.044 13.3 0.0 1.2 1 0 0 1 1 1 0 GNAT acetyltransferase MOZ_SAS PF01853.18 CAV19627.1 - 0.04 13.6 0.0 0.056 13.1 0.0 1.3 1 0 0 1 1 1 0 MOZ/SAS family GNAT_acetyltr_2 PF13718.6 CAV19627.1 - 0.12 11.8 0.0 0.14 11.6 0.0 1.2 1 0 0 1 1 1 0 GNAT acetyltransferase 2 DNA_III_psi PF03603.13 CAV19628.1 - 1.5e-37 128.7 2.8 1.7e-37 128.5 2.8 1.0 1 0 0 1 1 1 1 DNA polymerase III psi subunit FAM180 PF15173.6 CAV19628.1 - 0.021 14.8 0.2 0.18 11.8 0.1 2.1 2 1 0 2 2 2 0 FAM180 family Acetyltransf_1 PF00583.25 CAV19629.1 - 9.6e-09 35.5 0.0 1.3e-08 35.1 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_9 PF13527.7 CAV19629.1 - 1.1e-08 35.3 0.0 1.6e-08 34.7 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 CAV19629.1 - 1.2e-07 32.0 0.0 1.8e-07 31.5 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 CAV19629.1 - 0.00022 21.2 0.0 0.00064 19.7 0.0 1.7 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 CAV19629.1 - 0.0044 17.1 0.0 0.0084 16.2 0.0 1.5 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase Acetyltransf_15 PF17013.5 CAV19629.1 - 0.078 12.4 0.0 0.089 12.2 0.0 1.2 1 0 0 1 1 1 0 Putative acetyl-transferase SCP2 PF02036.17 CAV19630.1 - 1.2e-18 67.5 0.4 2e-18 66.8 0.4 1.4 1 0 0 1 1 1 1 SCP-2 sterol transfer family Alkyl_sulf_C PF14864.6 CAV19630.1 - 0.00042 20.6 0.0 0.001 19.3 0.0 1.5 1 1 0 1 1 1 1 Alkyl sulfatase C-terminal MDMPI_C PF07398.11 CAV19630.1 - 0.16 12.9 0.0 0.24 12.3 0.0 1.4 1 0 0 1 1 1 0 MDMPI C-terminal domain EAL PF00563.20 CAV19631.1 - 1.9e-72 243.6 0.0 3.7e-72 242.7 0.0 1.5 1 0 0 1 1 1 1 EAL domain GGDEF PF00990.21 CAV19631.1 - 1.1e-40 139.0 0.0 2.3e-40 138.0 0.0 1.6 1 0 0 1 1 1 1 Diguanylate cyclase, GGDEF domain PAS_8 PF13188.7 CAV19631.1 - 5.2e-09 35.9 0.0 4.4e-05 23.4 0.0 2.8 2 0 0 2 2 2 2 PAS domain PAS_4 PF08448.10 CAV19631.1 - 2.9e-08 33.9 0.0 3.4e-07 30.5 0.0 2.3 2 0 0 2 2 2 1 PAS fold PAS PF00989.25 CAV19631.1 - 4.9e-07 29.7 0.0 0.011 15.8 0.0 2.7 2 0 0 2 2 2 2 PAS fold PAS_9 PF13426.7 CAV19631.1 - 1.2e-06 28.7 0.0 0.0071 16.6 0.0 2.6 2 0 0 2 2 2 2 PAS domain Peptidase_U32 PF01136.19 CAV19632.1 - 1.6e-68 230.3 0.0 2e-68 230.0 0.0 1.1 1 0 0 1 1 1 1 Peptidase family U32 Peptidase_U32 PF01136.19 CAV19633.1 - 2.4e-15 56.4 0.0 3.5e-15 55.8 0.0 1.3 1 0 0 1 1 1 1 Peptidase family U32 MatE PF01554.18 CAV19634.1 - 3.4e-36 124.3 28.3 1.9e-22 79.7 8.4 2.4 2 0 0 2 2 2 2 MatE Polysacc_synt_C PF14667.6 CAV19634.1 - 2.6e-11 43.8 30.2 1.1e-08 35.2 19.8 4.6 2 1 2 4 4 4 2 Polysaccharide biosynthesis C-terminal domain MurJ PF03023.14 CAV19634.1 - 1.1e-08 34.2 29.3 0.00014 20.6 12.4 2.1 1 1 1 2 2 2 2 Lipid II flippase MurJ ArsP_1 PF03773.13 CAV19634.1 - 0.0024 17.0 16.2 0.0049 16.1 16.2 1.6 1 0 0 1 1 1 1 Predicted permease COX7B PF05392.11 CAV19634.1 - 0.18 11.5 1.6 2.8 7.7 0.2 2.8 2 0 0 2 2 2 0 Cytochrome C oxidase chain VIIB MarR PF01047.22 CAV19635.1 - 7.8e-13 48.2 0.1 1.2e-12 47.5 0.1 1.3 1 0 0 1 1 1 1 MarR family MarR_2 PF12802.7 CAV19635.1 - 3e-12 46.2 0.0 4.8e-12 45.6 0.0 1.3 1 0 0 1 1 1 1 MarR family Fe_dep_repress PF01325.19 CAV19635.1 - 6.8e-09 35.8 0.1 1.9e-08 34.3 0.1 1.8 1 0 0 1 1 1 1 Iron dependent repressor, N-terminal DNA binding domain HTH_27 PF13463.6 CAV19635.1 - 3.2e-06 27.5 0.1 4.7e-06 27.0 0.1 1.3 1 0 0 1 1 1 1 Winged helix DNA-binding domain HTH_IclR PF09339.10 CAV19635.1 - 2.9e-05 23.8 0.0 5.7e-05 22.8 0.0 1.4 1 0 0 1 1 1 1 IclR helix-turn-helix domain TrmB PF01978.19 CAV19635.1 - 0.00028 20.7 0.7 0.0025 17.6 0.1 2.3 1 1 1 2 2 2 1 Sugar-specific transcriptional regulator TrmB HTH_24 PF13412.6 CAV19635.1 - 0.021 14.4 0.0 0.036 13.6 0.0 1.4 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding HTH_Crp_2 PF13545.6 CAV19635.1 - 0.037 14.0 0.0 0.055 13.5 0.0 1.4 1 0 0 1 1 1 0 Crp-like helix-turn-helix domain Penicillinase_R PF03965.16 CAV19635.1 - 0.072 13.4 2.8 0.61 10.5 2.8 2.1 1 1 0 1 1 1 0 Penicillinase repressor Dimerisation PF08100.11 CAV19635.1 - 0.092 12.8 0.0 0.21 11.6 0.0 1.6 1 0 0 1 1 1 0 Dimerisation domain FtsZ_C PF12327.8 CAV19635.1 - 0.12 12.7 0.1 0.19 12.1 0.1 1.4 1 0 0 1 1 1 0 FtsZ family, C-terminal domain TPR_2 PF07719.17 CAV19636.1 - 7.3e-11 41.3 2.8 0.029 14.4 0.1 4.4 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_1 PF00515.28 CAV19636.1 - 1.4e-10 40.5 0.1 0.0015 18.2 0.0 3.6 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_8 PF13181.6 CAV19636.1 - 1.4e-06 28.0 0.1 0.74 10.2 0.0 3.7 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.6 CAV19636.1 - 1.7e-05 24.4 1.3 0.07 12.8 0.0 3.8 3 1 1 4 4 4 2 TPR repeat TPR_16 PF13432.6 CAV19636.1 - 3e-05 24.6 0.2 0.05 14.3 0.0 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_19 PF14559.6 CAV19636.1 - 0.0004 20.8 0.1 0.12 12.9 0.0 3.3 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_7 PF13176.6 CAV19636.1 - 0.00051 19.9 0.2 2.4 8.4 0.0 3.0 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_12 PF13424.6 CAV19636.1 - 0.0024 18.1 0.8 3 8.2 0.1 3.1 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_17 PF13431.6 CAV19636.1 - 0.004 17.4 2.7 2.4 8.7 0.0 3.6 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_14 PF13428.6 CAV19636.1 - 0.0046 17.7 0.0 4.5 8.4 0.0 3.8 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_3 PF07720.12 CAV19636.1 - 0.017 15.1 1.4 0.12 12.4 0.5 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_9 PF13371.6 CAV19636.1 - 0.048 13.8 0.0 0.11 12.6 0.0 1.7 1 0 0 1 1 1 0 Tetratricopeptide repeat RNase_PH PF01138.21 CAV19637.1 - 1.5e-41 142.0 0.0 3.9e-20 72.7 0.0 2.5 2 0 0 2 2 2 2 3' exoribonuclease family, domain 1 PNPase PF03726.14 CAV19637.1 - 1.2e-24 86.5 2.0 3.9e-24 84.9 2.0 1.9 1 0 0 1 1 1 1 Polyribonucleotide nucleotidyltransferase, RNA binding domain S1 PF00575.23 CAV19637.1 - 1e-19 70.6 2.7 1.1e-19 70.5 1.0 2.1 2 0 0 2 2 2 1 S1 RNA binding domain RNase_PH_C PF03725.15 CAV19637.1 - 1.3e-17 63.6 3.0 6.6e-12 45.3 0.1 2.8 2 0 0 2 2 2 2 3' exoribonuclease family, domain 2 KH_1 PF00013.29 CAV19637.1 - 3.9e-10 39.4 3.2 5.5e-09 35.7 3.3 2.7 2 0 0 2 2 2 1 KH domain KH_2 PF07650.17 CAV19637.1 - 0.01 15.7 1.8 0.018 14.9 0.3 2.2 2 0 0 2 2 2 0 KH domain Cauli_DNA-bind PF03310.13 CAV19637.1 - 0.041 13.9 0.4 0.18 11.8 0.0 2.3 3 0 0 3 3 3 0 Caulimovirus DNA-binding protein S1_2 PF13509.6 CAV19637.1 - 0.065 13.3 0.0 0.43 10.7 0.0 2.4 1 1 1 2 2 2 0 S1 domain DUF3016 PF11454.8 CAV19637.1 - 0.093 12.5 0.2 0.8 9.5 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3016) SLS PF14611.6 CAV19637.1 - 0.1 12.4 0.5 0.21 11.4 0.1 1.7 2 0 0 2 2 2 0 Mitochondrial inner-membrane-bound regulator Ribosomal_S15 PF00312.22 CAV19638.1 - 2.5e-36 123.7 0.6 2.9e-36 123.5 0.6 1.0 1 0 0 1 1 1 1 Ribosomal protein S15 TruB_N PF01509.18 CAV19639.1 - 9.8e-59 198.0 0.0 1.5e-58 197.4 0.0 1.3 1 0 0 1 1 1 1 TruB family pseudouridylate synthase (N terminal domain) TruB_C_2 PF16198.5 CAV19639.1 - 6e-24 84.0 0.6 1.4e-23 82.8 0.3 1.8 2 0 0 2 2 2 1 tRNA pseudouridylate synthase B C-terminal domain TruB-C_2 PF09157.11 CAV19639.1 - 3.4e-18 65.4 0.1 8.3e-18 64.2 0.1 1.7 1 0 0 1 1 1 1 Pseudouridine synthase II TruB, C-terminal SHS2_FTSA PF02491.20 CAV19639.1 - 0.095 13.1 0.1 4 7.9 0.0 2.5 2 0 0 2 2 2 0 SHS2 domain inserted in FTSA E2_bind PF08825.10 CAV19639.1 - 0.17 12.1 0.4 0.55 10.4 0.3 1.9 2 0 0 2 2 2 0 E2 binding domain RBFA PF02033.18 CAV19640.1 - 3.7e-28 98.1 0.2 4.6e-28 97.7 0.2 1.1 1 0 0 1 1 1 1 Ribosome-binding factor A IF-2 PF11987.8 CAV19641.1 - 2.3e-37 127.3 1.3 1e-36 125.2 1.3 2.3 1 0 0 1 1 1 1 Translation-initiation factor 2 GTP_EFTU PF00009.27 CAV19641.1 - 3.2e-31 108.4 2.8 3.2e-31 108.4 2.8 3.7 3 2 0 3 3 3 1 Elongation factor Tu GTP binding domain IF2_N PF04760.15 CAV19641.1 - 5e-23 80.7 9.0 1.1e-14 54.0 2.2 2.9 2 0 0 2 2 2 2 Translation initiation factor IF-2, N-terminal region IF2_assoc PF08364.11 CAV19641.1 - 4.1e-16 58.9 7.6 1.3e-15 57.3 7.6 2.0 1 0 0 1 1 1 1 Bacterial translation initiation factor IF-2 associated region GTP_EFTU_D2 PF03144.25 CAV19641.1 - 2e-10 40.9 3.2 2.5e-06 27.8 0.6 3.3 2 0 0 2 2 2 2 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 CAV19641.1 - 2e-08 34.3 0.1 2e-08 34.3 0.1 2.5 2 1 0 2 2 2 1 50S ribosome-binding GTPase MMR_HSR1_Xtn PF16897.5 CAV19641.1 - 0.0035 17.3 0.0 0.014 15.4 0.0 2.0 1 0 0 1 1 1 1 C-terminal region of MMR_HSR1 domain FeoB_N PF02421.18 CAV19641.1 - 0.0075 15.8 0.1 0.028 13.9 0.1 2.1 1 1 0 1 1 1 1 Ferrous iron transport protein B NOGCT PF08155.11 CAV19641.1 - 0.11 12.5 0.1 0.36 10.8 0.1 1.9 1 0 0 1 1 1 0 NOGCT (NUC087) domain NusA_N PF08529.11 CAV19642.1 - 3.4e-34 117.8 9.2 1e-33 116.2 9.2 1.9 1 0 0 1 1 1 1 NusA N-terminal domain KH_5 PF13184.6 CAV19642.1 - 2.7e-29 101.1 0.5 2.3e-27 94.9 0.3 2.6 2 0 0 2 2 2 1 NusA-like KH domain HHH_5 PF14520.6 CAV19642.1 - 2.7e-12 47.1 2.1 3e-07 30.9 1.1 3.1 2 0 0 2 2 2 2 Helix-hairpin-helix domain DUF4332 PF14229.6 CAV19642.1 - 0.00057 20.1 0.1 0.56 10.4 0.1 2.8 2 0 0 2 2 2 2 Domain of unknown function (DUF4332) S1 PF00575.23 CAV19642.1 - 0.0018 18.6 0.0 0.0063 16.8 0.0 2.0 1 0 0 1 1 1 1 S1 RNA binding domain KH_4 PF13083.6 CAV19642.1 - 0.014 15.2 1.4 0.077 12.9 0.0 2.8 3 0 0 3 3 3 0 KH domain DNA_pol_lambd_f PF10391.9 CAV19642.1 - 0.015 15.1 0.0 3.6 7.5 0.0 2.9 3 0 0 3 3 3 0 Fingers domain of DNA polymerase lambda DUF150 PF02576.17 CAV19643.1 - 9e-29 99.7 0.2 1.7e-28 98.8 0.1 1.6 2 0 0 2 2 2 1 RimP N-terminal domain DUF150_C PF17384.2 CAV19643.1 - 4.2e-20 71.7 0.3 5.8e-20 71.2 0.3 1.2 1 0 0 1 1 1 1 RimP C-terminal SH3 domain SecG PF03840.14 CAV19644.1 - 4.1e-21 74.8 9.6 5.9e-21 74.3 9.6 1.2 1 0 0 1 1 1 1 Preprotein translocase SecG subunit PGM_PMM_I PF02878.16 CAV19645.1 - 9.3e-46 155.0 0.0 2.1e-45 153.8 0.0 1.6 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_III PF02880.16 CAV19645.1 - 9.8e-32 109.5 0.7 9.1e-31 106.4 0.2 2.4 2 0 0 2 2 2 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_II PF02879.16 CAV19645.1 - 4.3e-19 69.0 0.1 1.1e-18 67.7 0.1 1.8 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_IV PF00408.20 CAV19645.1 - 2.3e-13 50.1 0.7 6.5e-13 48.7 0.7 1.8 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain KDGP_aldolase PF07071.11 CAV19645.1 - 0.0098 15.7 0.2 2.1 8.1 0.1 2.2 2 0 0 2 2 2 2 KDGP aldolase ATP13 PF12921.7 CAV19645.1 - 0.08 12.8 0.0 0.15 11.9 0.0 1.3 1 0 0 1 1 1 0 Mitochondrial ATPase expression Pterin_bind PF00809.22 CAV19646.1 - 6.8e-92 307.6 0.0 7.8e-92 307.4 0.0 1.0 1 0 0 1 1 1 1 Pterin binding enzyme GDPD_2 PF13653.6 CAV19646.1 - 0.038 14.5 0.1 0.16 12.5 0.0 2.0 2 0 0 2 2 2 0 Glycerophosphoryl diester phosphodiesterase family Peptidase_M41 PF01434.18 CAV19647.1 - 3.3e-72 242.3 0.3 5.7e-72 241.6 0.3 1.4 1 0 0 1 1 1 1 Peptidase family M41 AAA PF00004.29 CAV19647.1 - 1.3e-46 158.3 0.0 2.6e-46 157.3 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) FtsH_ext PF06480.15 CAV19647.1 - 4.6e-13 49.5 1.0 9.1e-13 48.5 0.2 1.8 2 0 0 2 2 2 1 FtsH Extracellular AAA_lid_3 PF17862.1 CAV19647.1 - 7e-11 41.8 0.0 1.3e-10 40.8 0.0 1.5 1 0 0 1 1 1 1 AAA+ lid domain AAA_5 PF07728.14 CAV19647.1 - 7.4e-06 26.0 0.0 4.7e-05 23.4 0.0 2.3 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) TIP49 PF06068.13 CAV19647.1 - 3.9e-05 23.0 0.0 7.4e-05 22.1 0.0 1.5 1 0 0 1 1 1 1 TIP49 P-loop domain RuvB_N PF05496.12 CAV19647.1 - 0.00031 20.5 0.0 0.0011 18.7 0.0 1.9 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 CAV19647.1 - 0.00057 20.3 2.3 0.0051 17.2 0.1 2.7 2 1 0 3 3 3 1 AAA ATPase domain AAA_2 PF07724.14 CAV19647.1 - 0.0011 19.1 0.0 0.0068 16.5 0.0 2.3 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.6 CAV19647.1 - 0.0013 19.0 0.1 0.023 15.0 0.1 2.5 1 1 0 1 1 1 1 AAA domain IstB_IS21 PF01695.17 CAV19647.1 - 0.0026 17.5 0.0 0.0051 16.6 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein Mg_chelatase PF01078.21 CAV19647.1 - 0.0088 15.5 0.2 0.021 14.2 0.2 1.5 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_28 PF13521.6 CAV19647.1 - 0.01 16.1 0.7 0.16 12.2 0.0 2.7 3 0 0 3 3 2 0 AAA domain AAA_33 PF13671.6 CAV19647.1 - 0.01 16.0 0.0 0.022 14.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain SurA_N_3 PF13624.6 CAV19647.1 - 0.022 14.5 0.2 0.076 12.8 0.2 2.0 1 0 0 1 1 1 0 SurA N-terminal domain AAA_18 PF13238.6 CAV19647.1 - 0.035 14.6 0.0 0.091 13.3 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.6 CAV19647.1 - 0.038 13.7 0.0 0.13 11.9 0.0 2.0 1 0 0 1 1 1 0 AAA domain AAA_PrkA PF08298.11 CAV19647.1 - 0.04 12.8 0.0 0.064 12.2 0.0 1.2 1 0 0 1 1 1 0 PrkA AAA domain ABC_tran PF00005.27 CAV19647.1 - 0.043 14.3 0.1 0.17 12.4 0.1 2.0 1 0 0 1 1 1 0 ABC transporter FlgO PF17680.1 CAV19647.1 - 0.05 13.3 0.0 0.11 12.2 0.0 1.5 1 0 0 1 1 1 0 FlgO protein CSTF2_hinge PF14327.6 CAV19647.1 - 0.058 13.9 0.0 0.12 12.9 0.0 1.5 1 0 0 1 1 1 0 Hinge domain of cleavage stimulation factor subunit 2 Sigma54_activat PF00158.26 CAV19647.1 - 0.081 12.6 0.0 0.36 10.5 0.0 2.0 1 1 0 1 1 1 0 Sigma-54 interaction domain AAA_14 PF13173.6 CAV19647.1 - 0.11 12.5 0.0 0.31 11.1 0.0 1.7 1 0 0 1 1 1 0 AAA domain TsaE PF02367.17 CAV19647.1 - 0.12 12.4 0.0 0.24 11.4 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_7 PF12775.7 CAV19647.1 - 0.19 11.2 0.2 0.54 9.7 0.2 1.7 1 1 0 1 1 1 0 P-loop containing dynein motor region FtsJ PF01728.19 CAV19648.1 - 2.1e-57 194.1 0.0 2.5e-57 193.9 0.0 1.1 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_31 PF13847.6 CAV19648.1 - 0.0013 18.6 0.4 2.2 8.1 0.1 2.6 2 1 1 3 3 3 2 Methyltransferase domain Methyltr_RsmB-F PF01189.17 CAV19648.1 - 0.0043 16.7 0.0 0.0096 15.6 0.0 1.5 1 0 0 1 1 1 1 16S rRNA methyltransferase RsmB/F Methyltransf_25 PF13649.6 CAV19648.1 - 0.083 13.6 0.3 0.59 10.9 0.2 2.4 1 1 1 2 2 2 0 Methyltransferase domain Pyr_redox_3 PF13738.6 CAV19648.1 - 0.11 11.7 0.0 0.16 11.2 0.0 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase CRS1_YhbY PF01985.21 CAV19649.1 - 8.9e-20 70.7 1.5 1e-19 70.5 1.5 1.0 1 0 0 1 1 1 1 CRS1 / YhbY (CRM) domain Coatomer_g_Cpla PF16381.5 CAV19649.1 - 0.045 13.9 0.1 0.061 13.5 0.1 1.2 1 0 0 1 1 1 0 Coatomer subunit gamma-1 C-terminal appendage platform GreA_GreB PF01272.19 CAV19650.1 - 7.3e-27 93.1 0.4 1.2e-26 92.4 0.4 1.3 1 0 0 1 1 1 1 Transcription elongation factor, GreA/GreB, C-term GreA_GreB_N PF03449.15 CAV19650.1 - 6.3e-24 83.9 1.1 8.9e-24 83.4 1.1 1.2 1 0 0 1 1 1 1 Transcription elongation factor, N-terminal DUF1953 PF09196.10 CAV19650.1 - 0.14 12.0 1.2 0.33 10.8 0.1 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF1953) Porin_4 PF13609.6 CAV19651.1 - 8.7e-30 104.5 40.9 1.4e-29 103.9 40.9 1.3 1 0 0 1 1 1 1 Gram-negative porin Porin_1 PF00267.21 CAV19651.1 - 1.7e-18 67.2 26.0 1.8e-16 60.5 26.0 2.4 1 1 0 1 1 1 1 Gram-negative porin Peptidase_S13 PF02113.15 CAV19652.1 - 2.6e-96 323.1 0.2 3.4e-96 322.7 0.2 1.0 1 0 0 1 1 1 1 D-Ala-D-Ala carboxypeptidase 3 (S13) family Beta-lactamase2 PF13354.6 CAV19652.1 - 4.8e-05 23.1 0.4 0.16 11.6 0.3 2.7 2 1 0 2 2 2 2 Beta-lactamase enzyme family MgtE PF01769.16 CAV19653.1 - 5.3e-27 94.7 7.5 5.3e-27 94.7 7.5 2.0 2 0 0 2 2 2 1 Divalent cation transporter MgtE_N PF03448.17 CAV19653.1 - 0.15 12.7 0.1 0.25 11.9 0.1 1.3 1 0 0 1 1 1 0 MgtE intracellular N domain Wzz PF02706.15 CAV19653.1 - 7.1 7.0 7.9 5.3 7.4 0.4 3.0 3 0 0 3 3 3 0 Chain length determinant protein tRNA-synt_1b PF00579.25 CAV19654.1 - 2e-78 263.7 0.0 2.6e-78 263.3 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) TyrRSs_C PF16714.5 CAV19654.1 - 0.0015 18.3 0.0 0.0029 17.4 0.0 1.4 1 0 0 1 1 1 1 Tyrosyl-tRNA synthetase C-terminal domain S4 PF01479.25 CAV19654.1 - 0.0027 17.4 0.0 0.0046 16.6 0.0 1.4 1 0 0 1 1 1 1 S4 domain Peptidase_M23 PF01551.22 CAV19655.1 - 7.5e-31 106.2 3.9 1.7e-30 105.1 2.1 2.1 2 0 0 2 2 2 1 Peptidase family M23 OapA_N PF08525.11 CAV19655.1 - 1.2e-05 25.1 5.0 2.3e-05 24.2 5.0 1.5 1 0 0 1 1 1 1 Opacity-associated protein A N-terminal motif OapA PF04225.12 CAV19655.1 - 0.00019 21.5 0.0 0.00062 19.8 0.0 1.9 1 0 0 1 1 1 1 Opacity-associated protein A LysM-like domain Biotin_lipoyl_2 PF13533.6 CAV19655.1 - 0.057 13.2 0.9 0.12 12.2 0.2 1.9 2 0 0 2 2 2 0 Biotin-lipoyl like ACR_tran PF00873.19 CAV19656.1 - 9.7e-163 543.3 15.6 1.2e-162 543.0 15.6 1.1 1 0 0 1 1 1 1 AcrB/AcrD/AcrF family MMPL PF03176.15 CAV19656.1 - 3e-07 29.7 35.1 0.0014 17.6 8.4 3.3 2 1 0 2 2 2 2 MMPL family Patched PF02460.18 CAV19656.1 - 2.3e-05 22.7 10.2 2.3e-05 22.7 10.2 2.0 2 0 0 2 2 2 1 Patched family HlyD_3 PF13437.6 CAV19657.1 - 1e-21 77.6 0.8 2.2e-16 60.4 0.1 2.6 2 0 0 2 2 2 2 HlyD family secretion protein HlyD_D23 PF16576.5 CAV19657.1 - 1.6e-19 70.0 0.2 2.6e-19 69.3 0.2 1.3 1 0 0 1 1 1 1 Barrel-sandwich domain of CusB or HlyD membrane-fusion Biotin_lipoyl_2 PF13533.6 CAV19657.1 - 2.6e-11 43.2 13.0 1.1e-09 37.9 3.7 3.2 3 1 0 3 3 3 2 Biotin-lipoyl like Biotin_lipoyl PF00364.22 CAV19657.1 - 5.9e-08 32.4 4.1 0.0023 17.7 0.1 3.2 3 0 0 3 3 3 2 Biotin-requiring enzyme GTP_CH_N PF12471.8 CAV19657.1 - 0.046 13.5 0.2 0.63 9.8 0.1 2.1 2 0 0 2 2 2 0 GTP cyclohydrolase N terminal RnfC_N PF13375.6 CAV19657.1 - 0.14 12.1 1.9 1.6 8.8 0.4 2.6 2 1 0 2 2 2 0 RnfC Barrel sandwich hybrid domain OEP PF02321.18 CAV19657.1 - 0.31 10.8 4.8 0.51 10.1 4.8 1.4 1 0 0 1 1 1 0 Outer membrane efflux protein Fe-S_biosyn PF01521.20 CAV19658.1 - 3.6e-18 65.8 0.0 4.1e-18 65.6 0.0 1.0 1 0 0 1 1 1 1 Iron-sulphur cluster biosynthesis Aminotran_3 PF00202.21 CAV19659.1 - 2.3e-75 253.8 0.0 3e-75 253.4 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III Aminotran_1_2 PF00155.21 CAV19659.1 - 0.011 14.9 0.0 0.024 13.8 0.0 1.5 2 0 0 2 2 2 0 Aminotransferase class I and II AI-2E_transport PF01594.16 CAV19660.1 - 3.7e-52 177.5 34.8 4.5e-52 177.2 34.8 1.1 1 0 0 1 1 1 1 AI-2E family transporter YesK PF14150.6 CAV19660.1 - 0.0037 17.4 3.4 0.0037 17.4 3.4 3.4 3 1 1 4 4 4 1 YesK-like protein ThrE PF06738.12 CAV19660.1 - 0.0061 16.0 1.6 0.0061 16.0 1.6 2.7 2 1 1 3 3 3 1 Putative threonine/serine exporter SafA PF17073.5 CAV19660.1 - 0.014 15.3 0.5 0.16 11.9 0.1 2.6 2 0 0 2 2 2 0 Two-component-system connector protein MTS PF05175.14 CAV19661.1 - 6.5e-60 201.5 0.0 2.5e-59 199.6 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase small domain MTS_N PF08468.11 CAV19661.1 - 6.2e-57 192.0 0.0 2.1e-56 190.3 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase small domain N-terminal Methyltransf_31 PF13847.6 CAV19661.1 - 1.6e-06 28.0 0.0 2.8e-06 27.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CAV19661.1 - 3.8e-06 27.5 0.0 9.9e-06 26.2 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 CAV19661.1 - 1e-05 25.1 0.0 1.6e-05 24.4 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_12 PF08242.12 CAV19661.1 - 2.6e-05 24.9 0.0 7.3e-05 23.4 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CAV19661.1 - 0.0014 18.5 0.0 0.0028 17.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_16 PF10294.9 CAV19661.1 - 0.025 14.3 0.0 0.094 12.4 0.0 1.8 2 0 0 2 2 2 0 Lysine methyltransferase ORF45 PF17620.2 CAV19661.1 - 0.064 13.4 0.1 7.7 6.6 0.0 2.2 2 0 0 2 2 2 0 Family of unknown function UPF0020 PF01170.18 CAV19661.1 - 0.067 12.9 0.0 0.16 11.7 0.0 1.6 2 0 0 2 2 2 0 Putative RNA methylase family UPF0020 Response_reg PF00072.24 CAV19662.1 - 7e-32 109.9 0.0 2.3e-31 108.2 0.0 2.0 1 0 0 1 1 1 1 Response regulator receiver domain HATPase_c PF02518.26 CAV19662.1 - 3.8e-29 101.4 0.0 2e-28 99.2 0.0 2.3 2 1 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 CAV19662.1 - 3.3e-16 59.1 0.5 1.1e-14 54.1 0.0 3.3 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain HAMP PF00672.25 CAV19662.1 - 1.9e-13 50.5 0.1 1.1e-12 48.1 0.0 2.2 2 0 0 2 2 2 1 HAMP domain PAS_8 PF13188.7 CAV19662.1 - 4.5e-05 23.4 0.0 0.00018 21.4 0.0 2.0 1 0 0 1 1 1 1 PAS domain PAS PF00989.25 CAV19662.1 - 4.9e-05 23.3 0.1 0.00021 21.2 0.0 2.2 2 0 0 2 2 2 1 PAS fold PAS_4 PF08448.10 CAV19662.1 - 0.0035 17.6 0.0 0.0084 16.4 0.0 1.6 1 0 0 1 1 1 1 PAS fold MEKHLA PF08670.11 CAV19662.1 - 0.076 12.9 0.0 0.23 11.4 0.0 1.8 1 0 0 1 1 1 0 MEKHLA domain CoxIIa PF08113.11 CAV19662.1 - 0.79 9.6 2.5 1.7 8.5 2.5 1.6 1 0 0 1 1 1 0 Cytochrome c oxidase subunit IIa family Nsp1_C PF05064.13 CAV19662.1 - 8 6.3 8.6 0.44 10.4 2.3 2.2 2 0 0 2 2 2 0 Nsp1-like C-terminal region SBP_bac_5 PF00496.22 CAV19663.1 - 3.9e-73 246.6 11.0 7e-73 245.8 11.0 1.4 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 5 Middle BPD_transp_1 PF00528.22 CAV19664.1 - 6.7e-41 140.1 13.5 6.7e-41 140.1 13.5 1.8 2 0 0 2 2 2 1 Binding-protein-dependent transport system inner membrane component Archaeal_AmoA PF12942.7 CAV19664.1 - 0.0035 17.1 4.2 0.0035 17.1 4.2 1.9 2 1 0 2 2 2 1 Archaeal ammonia monooxygenase subunit A (AmoA) BPD_transp_1 PF00528.22 CAV19665.1 - 8.9e-18 64.7 14.7 8.9e-18 64.7 14.7 2.0 2 0 0 2 2 2 1 Binding-protein-dependent transport system inner membrane component OppC_N PF12911.7 CAV19665.1 - 1.7e-05 24.7 0.0 1.7e-05 24.7 0.0 2.8 4 0 0 4 4 4 1 N-terminal TM domain of oligopeptide transport permease C SPT_ssu-like PF11779.8 CAV19665.1 - 0.01 15.4 0.4 0.01 15.4 0.4 2.6 3 0 0 3 3 3 0 Small subunit of serine palmitoyltransferase-like ABC_tran PF00005.27 CAV19666.1 - 1.5e-26 93.6 0.0 2e-26 93.1 0.0 1.2 1 0 0 1 1 1 1 ABC transporter oligo_HPY PF08352.12 CAV19666.1 - 6.3e-18 65.1 0.1 1.1e-17 64.3 0.1 1.4 1 0 0 1 1 1 1 Oligopeptide/dipeptide transporter, C-terminal region AAA_21 PF13304.6 CAV19666.1 - 1.3e-06 28.4 0.2 5.5e-06 26.4 0.1 1.8 2 0 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_18 PF13238.6 CAV19666.1 - 0.001 19.6 0.0 0.0016 19.0 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 CAV19666.1 - 0.02 15.1 0.2 0.19 12.0 0.2 2.0 1 1 0 1 1 1 0 AAA domain SMC_N PF02463.19 CAV19666.1 - 0.023 14.2 0.6 0.14 11.6 0.1 2.0 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain PRK PF00485.18 CAV19666.1 - 0.049 13.4 0.0 0.072 12.8 0.0 1.3 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family AAA_25 PF13481.6 CAV19666.1 - 0.064 12.8 0.1 0.2 11.2 0.0 1.7 2 0 0 2 2 2 0 AAA domain AAA_29 PF13555.6 CAV19666.1 - 0.071 12.9 0.0 0.13 12.0 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_16 PF13191.6 CAV19666.1 - 0.077 13.4 0.0 0.11 12.8 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain Rad17 PF03215.15 CAV19666.1 - 0.1 12.5 0.0 0.21 11.5 0.0 1.5 1 1 0 1 1 1 0 Rad17 P-loop domain TniB PF05621.11 CAV19666.1 - 0.11 11.8 0.1 4.1 6.8 0.0 2.3 2 0 0 2 2 2 0 Bacterial TniB protein ABC_tran PF00005.27 CAV19667.1 - 1.8e-31 109.5 0.0 2.5e-31 109.0 0.0 1.2 1 0 0 1 1 1 1 ABC transporter oligo_HPY PF08352.12 CAV19667.1 - 8.8e-19 67.8 0.0 1.6e-18 67.0 0.0 1.4 1 0 0 1 1 1 1 Oligopeptide/dipeptide transporter, C-terminal region AAA_22 PF13401.6 CAV19667.1 - 0.00037 20.8 0.1 0.001 19.3 0.1 1.8 1 1 0 1 1 1 1 AAA domain DUF87 PF01935.17 CAV19667.1 - 0.0012 19.0 0.2 0.0035 17.5 0.2 1.7 2 0 0 2 2 2 1 Helicase HerA, central domain AAA_16 PF13191.6 CAV19667.1 - 0.004 17.6 0.0 0.0059 17.0 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain G-alpha PF00503.20 CAV19667.1 - 0.013 14.7 0.0 0.017 14.3 0.0 1.2 1 0 0 1 1 1 0 G-protein alpha subunit AAA_29 PF13555.6 CAV19667.1 - 0.023 14.4 0.2 0.053 13.3 0.1 1.6 2 0 0 2 2 2 0 P-loop containing region of AAA domain SMC_N PF02463.19 CAV19667.1 - 0.042 13.3 0.8 0.63 9.4 0.8 2.1 1 1 0 1 1 1 0 RecF/RecN/SMC N terminal domain AAA_30 PF13604.6 CAV19667.1 - 0.061 13.0 0.5 0.15 11.7 0.2 1.7 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 CAV19667.1 - 0.067 13.6 0.1 0.18 12.2 0.0 1.8 2 0 0 2 2 2 0 RNA helicase AAA_10 PF12846.7 CAV19667.1 - 0.08 11.8 0.0 0.12 11.2 0.0 1.2 1 0 0 1 1 1 0 AAA-like domain AAA PF00004.29 CAV19667.1 - 0.087 13.3 0.2 0.2 12.1 0.2 1.8 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_24 PF13479.6 CAV19667.1 - 0.12 12.0 0.0 0.18 11.5 0.0 1.2 1 0 0 1 1 1 0 AAA domain Zeta_toxin PF06414.12 CAV19667.1 - 0.17 11.1 0.1 0.29 10.4 0.1 1.3 1 0 0 1 1 1 0 Zeta toxin Baculo_PEP_N PF04512.12 CAV19667.1 - 0.19 12.1 0.0 0.35 11.2 0.0 1.5 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, N terminus AAA_33 PF13671.6 CAV19667.1 - 0.2 11.8 0.3 0.99 9.6 0.3 2.1 1 1 0 1 1 1 0 AAA domain Glyco_hydro_9 PF00759.19 CAV19668.1 - 4.9e-25 88.8 5.8 9.5e-25 87.9 5.8 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 9 CelD_N PF02927.14 CAV19668.1 - 1.2e-10 42.1 0.0 3.2e-10 40.7 0.0 1.7 1 0 0 1 1 1 1 Cellulase N-terminal ig-like domain BcrAD_BadFG PF01869.20 CAV19669.1 - 1.9e-46 158.7 1.3 2.2e-46 158.6 1.3 1.0 1 0 0 1 1 1 1 BadF/BadG/BcrA/BcrD ATPase family FGGY_N PF00370.21 CAV19669.1 - 0.015 14.8 0.0 0.022 14.4 0.0 1.2 1 0 0 1 1 1 0 FGGY family of carbohydrate kinases, N-terminal domain FlgT_N PF16548.5 CAV19669.1 - 0.24 12.0 3.1 0.42 11.2 1.1 2.1 2 0 0 2 2 2 0 Flagellar assembly protein T, N-terminal domain Glyco_hydro_20 PF00728.22 CAV19670.1 - 3.6e-119 398.3 1.1 4.7e-119 397.9 1.1 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 20, catalytic domain Glyco_hydro_20b PF02838.15 CAV19670.1 - 1.2e-17 64.9 0.0 2.3e-17 63.9 0.0 1.5 1 0 0 1 1 1 1 Glycosyl hydrolase family 20, domain 2 GHL10 PF02638.15 CAV19670.1 - 0.013 14.6 0.1 0.055 12.6 0.0 1.9 2 0 0 2 2 2 0 Glycosyl hydrolase-like 10 Glycohydro_20b2 PF14845.6 CAV19670.1 - 0.13 12.9 0.2 0.31 11.7 0.2 1.7 1 1 0 1 1 1 0 beta-acetyl hexosaminidase like Glyco_hydro_36 PF17167.4 CAV19671.1 - 1.8e-210 699.0 0.5 2.4e-210 698.6 0.5 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase 36 superfamily, catalytic domain Glyco_transf_36 PF06165.11 CAV19671.1 - 2.1e-85 286.1 1.7 3.5e-85 285.4 1.2 1.6 2 0 0 2 2 2 1 Glycosyltransferase family 36 GDE_C PF06202.14 CAV19671.1 - 0.00075 18.5 0.0 0.0041 16.1 0.0 2.0 1 1 0 1 1 1 1 Amylo-alpha-1,6-glucosidase DUF608 PF04685.13 CAV19671.1 - 0.0033 16.6 0.1 0.0059 15.8 0.1 1.3 1 0 0 1 1 1 1 Glycosyl-hydrolase family 116, catalytic region Bac_rhamnosid6H PF17389.2 CAV19671.1 - 0.0048 16.2 1.6 0.0062 15.8 0.3 1.8 1 1 1 2 2 2 1 Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain Glyco_hydro_65C PF03633.15 CAV19671.1 - 0.14 12.1 0.0 0.32 10.9 0.0 1.6 1 0 0 1 1 1 0 Glycosyl hydrolase family 65, C-terminal domain PGM_PMM_I PF02878.16 CAV19672.1 - 3.5e-38 130.4 0.0 7.7e-38 129.3 0.0 1.6 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_III PF02880.16 CAV19672.1 - 2e-25 89.2 0.0 3.4e-25 88.4 0.0 1.4 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_II PF02879.16 CAV19672.1 - 5.6e-24 84.7 0.2 1.7e-23 83.2 0.1 1.9 2 0 0 2 2 2 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_IV PF00408.20 CAV19672.1 - 2.4e-10 40.4 0.0 2.2e-09 37.3 0.0 2.4 2 0 0 2 2 2 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain ABC_tran PF00005.27 CAV19673.1 - 1.5e-35 122.7 0.0 2.6e-35 121.9 0.0 1.4 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 CAV19673.1 - 1.4e-12 48.0 0.2 4.9e-06 26.6 0.1 2.2 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA PF00004.29 CAV19673.1 - 1.5e-06 28.7 0.0 3.8e-05 24.1 0.0 2.3 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) SMC_N PF02463.19 CAV19673.1 - 5.4e-05 22.7 0.2 0.038 13.4 0.1 2.2 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain RsgA_GTPase PF03193.16 CAV19673.1 - 0.00026 20.9 0.2 0.00078 19.4 0.1 1.7 2 0 0 2 2 2 1 RsgA GTPase AAA_15 PF13175.6 CAV19673.1 - 0.00062 19.6 0.0 0.0015 18.3 0.0 1.5 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 CAV19673.1 - 0.0012 19.1 0.9 0.0095 16.2 0.9 2.1 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 CAV19673.1 - 0.0015 18.9 0.0 0.0029 18.0 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain AAA_18 PF13238.6 CAV19673.1 - 0.0015 19.1 0.1 0.025 15.1 0.1 2.4 1 1 0 1 1 1 1 AAA domain SbcCD_C PF13558.6 CAV19673.1 - 0.0016 18.6 0.2 0.03 14.5 0.1 2.8 1 1 1 2 2 2 1 Putative exonuclease SbcCD, C subunit TOBE_2 PF08402.10 CAV19673.1 - 0.0017 18.4 0.1 0.0073 16.5 0.0 2.1 2 1 0 2 2 1 1 TOBE domain AAA_29 PF13555.6 CAV19673.1 - 0.0022 17.7 0.1 0.0043 16.8 0.1 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain NACHT PF05729.12 CAV19673.1 - 0.0023 17.8 0.4 0.0049 16.8 0.2 1.6 2 0 0 2 2 1 1 NACHT domain Rad17 PF03215.15 CAV19673.1 - 0.0025 17.8 0.1 0.0049 16.8 0.1 1.5 1 1 0 1 1 1 1 Rad17 P-loop domain PduV-EutP PF10662.9 CAV19673.1 - 0.0029 17.4 0.5 0.051 13.3 0.1 2.3 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation AAA_5 PF07728.14 CAV19673.1 - 0.0031 17.5 0.0 0.006 16.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_25 PF13481.6 CAV19673.1 - 0.0032 17.1 0.2 0.86 9.1 0.1 2.3 2 0 0 2 2 2 1 AAA domain NB-ARC PF00931.22 CAV19673.1 - 0.0033 16.7 0.1 0.007 15.6 0.1 1.7 1 1 0 1 1 1 1 NB-ARC domain AAA_23 PF13476.6 CAV19673.1 - 0.0035 17.9 0.6 0.0092 16.5 0.0 1.8 2 1 0 2 2 2 1 AAA domain ATPase PF06745.13 CAV19673.1 - 0.0048 16.3 0.2 0.77 9.1 0.0 2.2 2 0 0 2 2 2 1 KaiC ABC_ATPase PF09818.9 CAV19673.1 - 0.0057 15.5 0.4 2.6 6.8 0.0 2.8 2 1 0 2 2 2 1 Predicted ATPase of the ABC class AAA_28 PF13521.6 CAV19673.1 - 0.0057 16.9 0.5 0.015 15.6 0.5 1.6 2 0 0 2 2 1 1 AAA domain G-alpha PF00503.20 CAV19673.1 - 0.0082 15.3 0.1 0.028 13.6 0.1 1.7 1 1 0 1 1 1 1 G-protein alpha subunit AAA_33 PF13671.6 CAV19673.1 - 0.01 16.0 0.0 0.031 14.5 0.0 1.7 1 1 0 1 1 1 0 AAA domain Mg_chelatase PF01078.21 CAV19673.1 - 0.012 15.0 0.0 0.031 13.7 0.0 1.6 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_14 PF13173.6 CAV19673.1 - 0.013 15.5 0.0 0.046 13.8 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_24 PF13479.6 CAV19673.1 - 0.016 14.9 0.1 0.59 9.8 0.0 2.2 2 0 0 2 2 2 0 AAA domain TsaE PF02367.17 CAV19673.1 - 0.017 15.1 0.1 0.038 14.0 0.1 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE IstB_IS21 PF01695.17 CAV19673.1 - 0.018 14.7 0.1 0.69 9.6 0.0 2.3 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA_19 PF13245.6 CAV19673.1 - 0.023 15.0 0.8 0.65 10.3 0.0 2.8 2 1 0 2 2 2 0 AAA domain ATPase_2 PF01637.18 CAV19673.1 - 0.033 14.1 0.0 0.085 12.8 0.0 1.6 2 0 0 2 2 1 0 ATPase domain predominantly from Archaea Viral_helicase1 PF01443.18 CAV19673.1 - 0.041 13.6 0.0 0.081 12.7 0.0 1.5 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase T2SSE PF00437.20 CAV19673.1 - 0.05 12.7 0.0 0.15 11.1 0.0 1.7 2 0 0 2 2 2 0 Type II/IV secretion system protein AAA_30 PF13604.6 CAV19673.1 - 0.052 13.3 0.1 0.44 10.2 0.0 2.1 2 0 0 2 2 2 0 AAA domain MobB PF03205.14 CAV19673.1 - 0.1 12.5 0.1 0.3 11.0 0.1 1.8 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B NTPase_1 PF03266.15 CAV19673.1 - 0.11 12.4 0.5 4.2 7.2 0.1 2.2 2 0 0 2 2 2 0 NTPase BPD_transp_1 PF00528.22 CAV19674.1 - 5.6e-22 78.4 27.5 2.1e-15 56.9 9.7 4.1 2 2 2 5 5 5 3 Binding-protein-dependent transport system inner membrane component SBP_bac_6 PF13343.6 CAV19675.1 - 8.4e-17 61.4 0.2 1.3e-16 60.8 0.2 1.1 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_11 PF13531.6 CAV19675.1 - 1.7e-14 54.1 0.0 2.3e-14 53.7 0.0 1.1 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_8 PF13416.6 CAV19675.1 - 1.7e-12 47.7 1.8 3e-12 46.9 1.8 1.3 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_1 PF01547.25 CAV19675.1 - 2.2e-11 44.3 1.0 6.4e-11 42.8 1.0 1.6 1 1 0 1 1 1 1 Bacterial extracellular solute-binding protein Urease_beta PF00699.20 CAV19675.1 - 0.026 14.5 0.0 0.048 13.7 0.0 1.4 1 0 0 1 1 1 0 Urease beta subunit Ammonium_transp PF00909.21 CAV19676.1 - 3.1e-99 332.4 32.3 5.8e-99 331.5 32.3 1.4 1 1 0 1 1 1 1 Ammonium Transporter Family DUF3948 PF13134.6 CAV19676.1 - 0.5 10.1 5.7 6.3 6.6 0.1 3.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3948) P-II PF00543.22 CAV19677.1 - 1.8e-43 147.3 0.5 2e-43 147.1 0.5 1.0 1 0 0 1 1 1 1 Nitrogen regulatory protein P-II DUF3240 PF11582.8 CAV19677.1 - 0.0021 18.2 0.0 0.0031 17.6 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3240) DUF3364 PF11844.8 CAV19677.1 - 0.024 14.9 0.0 0.038 14.2 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3364) CdAMP_rec PF06153.11 CAV19677.1 - 0.041 14.1 0.1 0.073 13.3 0.1 1.5 1 1 0 1 1 1 0 Cyclic-di-AMP receptor Nit_Regul_Hom PF10126.9 CAV19677.1 - 0.044 13.8 0.0 10 6.2 0.0 2.2 2 0 0 2 2 2 0 Uncharacterized protein, homolog of nitrogen regulatory protein PII SecB PF02556.14 CAV19677.1 - 0.13 12.2 0.0 0.17 11.8 0.0 1.2 1 0 0 1 1 1 0 Preprotein translocase subunit SecB UPF0231 PF06062.11 CAV19678.1 - 2.1e-40 137.7 3.7 2.4e-40 137.6 3.7 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0231) Phage_Gp19 PF09355.10 CAV19678.1 - 0.11 12.9 0.1 0.16 12.4 0.1 1.2 1 0 0 1 1 1 0 Phage protein Gp19/Gp15/Gp42 Aconitase_2_N PF06434.13 CAV19679.1 - 2e-95 318.3 0.0 3e-95 317.7 0.0 1.3 1 0 0 1 1 1 1 Aconitate hydratase 2 N-terminus Aconitase_B_N PF11791.8 CAV19679.1 - 3.8e-65 218.6 0.1 6.4e-65 217.9 0.1 1.4 1 0 0 1 1 1 1 Aconitate B N-terminal domain Aconitase PF00330.20 CAV19679.1 - 1.4e-43 149.6 0.0 8.9e-42 143.6 0.0 2.4 1 1 0 1 1 1 1 Aconitase family (aconitate hydratase) Patatin PF01734.22 CAV19680.1 - 5.4e-30 105.1 0.2 1.7e-29 103.5 0.2 1.9 1 1 0 1 1 1 1 Patatin-like phospholipase POTRA PF07244.15 CAV19680.1 - 0.00036 21.1 2.7 0.00036 21.1 2.7 1.9 2 0 0 2 2 2 1 Surface antigen variable number repeat Bac_surface_Ag PF01103.23 CAV19680.1 - 0.0038 16.8 2.3 0.0038 16.8 2.3 2.4 2 1 0 2 2 2 1 Surface antigen Scm3 PF10384.9 CAV19680.1 - 0.038 13.7 0.0 0.084 12.6 0.0 1.5 1 0 0 1 1 1 0 Centromere protein Scm3 Transgly PF00912.22 CAV19681.1 - 2.7e-60 202.9 0.0 4.6e-60 202.1 0.0 1.3 1 0 0 1 1 1 1 Transglycosylase Transpeptidase PF00905.22 CAV19681.1 - 1.5e-26 93.3 0.0 2.6e-26 92.5 0.0 1.3 1 0 0 1 1 1 1 Penicillin binding protein transpeptidase domain UB2H PF14814.6 CAV19681.1 - 3e-26 91.2 0.0 5.5e-26 90.4 0.0 1.4 1 0 0 1 1 1 1 Bifunctional transglycosylase second domain HrpB_C PF08482.10 CAV19683.1 - 1.4e-52 177.6 0.3 7.9e-52 175.2 0.3 2.3 3 0 0 3 3 3 1 ATP-dependent helicase C-terminal Helicase_C PF00271.31 CAV19683.1 - 4.4e-14 52.8 0.1 1.6e-13 51.0 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 CAV19683.1 - 7.8e-09 35.5 1.6 1.1e-07 31.9 0.3 2.3 2 0 0 2 2 2 1 DEAD/DEAH box helicase HA2 PF04408.23 CAV19683.1 - 8.1e-09 35.7 0.6 1.6e-08 34.7 0.6 1.5 1 0 0 1 1 1 1 Helicase associated domain (HA2) SfsA PF03749.13 CAV19684.1 - 1.5e-45 154.5 0.1 3.2e-45 153.4 0.1 1.5 1 1 0 1 1 1 1 Sugar fermentation stimulation protein RE domain SfsA_N PF17746.1 CAV19684.1 - 1.1e-19 70.3 0.0 2.9e-19 69.0 0.0 1.7 1 0 0 1 1 1 1 SfsA N-terminal OB domain HSDR_N PF04313.14 CAV19684.1 - 0.014 15.4 0.0 0.021 14.8 0.0 1.4 1 0 0 1 1 1 0 Type I restriction enzyme R protein N terminus (HSDR_N) DUF3883 PF13020.6 CAV19684.1 - 0.079 13.0 0.1 0.15 12.1 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3883) zf-dskA_traR PF01258.17 CAV19685.1 - 3.3e-10 39.7 1.6 5.7e-10 39.0 1.6 1.3 1 0 0 1 1 1 1 Prokaryotic dksA/traR C4-type zinc finger DZR PF12773.7 CAV19685.1 - 0.025 14.6 0.1 0.043 13.8 0.1 1.4 1 0 0 1 1 1 0 Double zinc ribbon RapH_N PF18801.1 CAV19685.1 - 0.17 12.0 0.8 20 5.4 0.2 2.3 2 0 0 2 2 2 0 response regulator aspartate phosphatase H, N terminal HBS1_N PF08938.10 CAV19685.1 - 0.63 10.4 0.0 0.63 10.4 0.0 2.2 2 1 1 3 3 3 0 HBS1 N-terminus tRNA-synt_1c PF00749.21 CAV19686.1 - 5.4e-42 143.8 0.0 1.6e-40 138.9 0.0 2.0 1 1 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain PolyA_pol_arg_C PF12626.7 CAV19687.1 - 3e-38 130.5 3.9 3e-38 130.5 3.9 2.1 2 0 0 2 2 2 1 Polymerase A arginine-rich C-terminus PolyA_pol PF01743.20 CAV19687.1 - 1.6e-37 128.8 0.8 3.4e-37 127.7 0.1 2.0 2 0 0 2 2 2 1 Poly A polymerase head domain PolyA_pol_RNAbd PF12627.7 CAV19687.1 - 4.5e-22 77.6 0.2 8.9e-22 76.6 0.2 1.5 1 0 0 1 1 1 1 Probable RNA and SrmB- binding site of polymerase A HPPK PF01288.20 CAV19688.1 - 4.9e-38 130.1 0.0 5.8e-38 129.8 0.0 1.1 1 0 0 1 1 1 1 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK) Pantoate_transf PF02548.15 CAV19689.1 - 3.9e-106 354.2 0.2 4.4e-106 354.0 0.2 1.0 1 0 0 1 1 1 1 Ketopantoate hydroxymethyltransferase Asp_Glu_race PF01177.22 CAV19689.1 - 0.00013 21.9 0.0 0.00025 21.0 0.0 1.4 1 0 0 1 1 1 1 Asp/Glu/Hydantoin racemase PEP_mutase PF13714.6 CAV19689.1 - 0.00017 21.1 0.3 0.00076 19.0 0.3 1.9 1 1 0 1 1 1 1 Phosphoenolpyruvate phosphomutase NanE PF04131.14 CAV19689.1 - 0.093 11.9 0.9 0.59 9.3 0.1 2.3 2 1 0 2 2 2 0 Putative N-acetylmannosamine-6-phosphate epimerase Pantoate_ligase PF02569.15 CAV19690.1 - 4.4e-100 334.3 0.0 5e-100 334.1 0.0 1.0 1 0 0 1 1 1 1 Pantoate-beta-alanine ligase CTP_transf_like PF01467.26 CAV19690.1 - 0.0055 16.9 0.2 0.096 12.9 0.0 2.3 2 1 0 2 2 2 1 Cytidylyltransferase-like ATP-sulfurylase PF01747.17 CAV19690.1 - 0.012 15.1 0.0 0.022 14.2 0.0 1.3 1 0 0 1 1 1 0 ATP-sulfurylase ABC2_membrane PF01061.24 CAV19691.1 - 2.6e-39 134.8 23.5 2.6e-39 134.8 23.5 1.4 2 0 0 2 2 2 1 ABC-2 type transporter ABC2_membrane_3 PF12698.7 CAV19691.1 - 4.5e-09 35.9 25.3 4.5e-09 35.9 25.3 1.4 1 1 0 1 1 1 1 ABC-2 family transporter protein CcmB PF03379.13 CAV19691.1 - 0.0085 15.6 5.8 0.0077 15.8 4.8 1.3 1 1 0 1 1 1 1 CcmB protein ABC_tran PF00005.27 CAV19693.1 - 3.4e-33 115.1 0.0 7.6e-33 113.9 0.0 1.6 2 0 0 2 2 2 1 ABC transporter AAA_21 PF13304.6 CAV19693.1 - 9.7e-13 48.6 2.7 1.2e-08 35.1 0.1 2.1 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_15 PF13175.6 CAV19693.1 - 2.4e-06 27.5 0.3 0.077 12.7 0.1 2.3 1 1 0 2 2 2 2 AAA ATPase domain SMC_N PF02463.19 CAV19693.1 - 7.5e-06 25.5 0.8 0.00027 20.5 0.1 2.4 2 1 0 2 2 2 1 RecF/RecN/SMC N terminal domain DUF4162 PF13732.6 CAV19693.1 - 0.00014 22.5 0.6 0.0005 20.7 0.3 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF4162) AAA_30 PF13604.6 CAV19693.1 - 0.0012 18.6 0.1 0.012 15.3 0.1 2.3 1 1 1 2 2 2 1 AAA domain AAA_29 PF13555.6 CAV19693.1 - 0.0021 17.8 0.3 0.0045 16.7 0.3 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_22 PF13401.6 CAV19693.1 - 0.0032 17.8 0.7 0.088 13.1 0.7 2.4 1 1 0 1 1 1 1 AAA domain AAA_27 PF13514.6 CAV19693.1 - 0.012 15.2 0.0 0.028 14.0 0.0 1.6 1 0 0 1 1 1 0 AAA domain SRP54 PF00448.22 CAV19693.1 - 0.025 14.2 0.1 0.051 13.2 0.1 1.4 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain AAA PF00004.29 CAV19693.1 - 0.11 12.9 2.3 1.3 9.5 0.8 2.7 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) CbiA PF01656.23 CAV19693.1 - 0.12 12.4 0.0 0.16 12.0 0.0 1.4 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_23 PF13476.6 CAV19693.1 - 0.13 12.8 3.7 0.36 11.3 3.7 2.1 1 1 0 1 1 1 0 AAA domain Sulfate_transp PF00916.20 CAV19694.1 - 1.4e-82 277.5 27.2 2.1e-82 276.9 27.2 1.3 1 0 0 1 1 1 1 Sulfate permease family STAS PF01740.21 CAV19694.1 - 6.1e-13 48.4 0.0 1.1e-12 47.6 0.0 1.4 1 0 0 1 1 1 1 STAS domain HCO3_cotransp PF00955.21 CAV19694.1 - 0.00038 19.4 10.4 0.033 13.0 0.7 2.3 2 0 0 2 2 2 2 HCO3- transporter family Pro_CA PF00484.19 CAV19695.1 - 1.9e-49 168.0 0.1 2.3e-49 167.7 0.1 1.1 1 0 0 1 1 1 1 Carbonic anhydrase Pribosyltran PF00156.27 CAV19697.1 - 5.6e-27 94.2 0.1 7.2e-27 93.8 0.1 1.0 1 0 0 1 1 1 1 Phosphoribosyl transferase domain UPRTase PF14681.6 CAV19697.1 - 1.8e-05 24.3 0.0 2.2e-05 24.0 0.0 1.1 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase PRTase_2 PF15609.6 CAV19697.1 - 0.052 13.0 0.3 0.1 12.1 0.1 1.5 2 0 0 2 2 2 0 Phosphoribosyl transferase Pribosyl_synth PF14572.6 CAV19697.1 - 0.12 12.4 0.1 0.18 11.8 0.1 1.2 1 0 0 1 1 1 0 Phosphoribosyl synthetase-associated domain TetR_N PF00440.23 CAV19699.1 - 1.6e-12 47.0 0.0 2.3e-12 46.5 0.0 1.3 1 0 0 1 1 1 1 Bacterial regulatory proteins, tetR family TetR_C_11 PF16859.5 CAV19699.1 - 0.0019 18.5 0.1 0.0097 16.2 0.0 2.0 2 1 0 2 2 2 1 Tetracyclin repressor-like, C-terminal domain TetR_C_24 PF17932.1 CAV19699.1 - 0.0047 17.2 0.0 0.01 16.1 0.0 1.5 1 0 0 1 1 1 1 Tetracyclin repressor-like, C-terminal domain TetR_C_6 PF13977.6 CAV19699.1 - 0.042 14.1 0.0 0.071 13.3 0.0 1.4 1 0 0 1 1 1 0 BetI-type transcriptional repressor, C-terminal Radial_spoke_3 PF06098.11 CAV19699.1 - 0.14 11.5 0.1 0.24 10.7 0.1 1.3 1 0 0 1 1 1 0 Radial spoke protein 3 Pyr_redox_2 PF07992.14 CAV19701.1 - 1.3e-61 208.5 3.6 1.8e-61 208.0 3.6 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.22 CAV19701.1 - 2.9e-35 120.9 0.1 6.8e-35 119.7 0.1 1.7 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.27 CAV19701.1 - 6.6e-18 65.1 6.1 8.5e-16 58.3 1.0 3.1 3 0 0 3 3 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 CAV19701.1 - 2e-08 34.0 0.2 4.1e-08 33.0 0.2 1.5 1 0 0 1 1 1 1 FAD dependent oxidoreductase GIDA PF01134.22 CAV19701.1 - 9.7e-08 31.5 0.6 2.3e-07 30.3 0.3 1.8 2 0 0 2 2 2 1 Glucose inhibited division protein A Pyr_redox_3 PF13738.6 CAV19701.1 - 1.4e-07 31.1 4.6 0.00041 19.7 1.8 3.4 2 1 1 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 CAV19701.1 - 6.7e-05 21.8 2.9 0.01 14.6 0.1 2.5 2 1 1 3 3 3 2 HI0933-like protein FAD_binding_2 PF00890.24 CAV19701.1 - 7.7e-05 21.9 5.1 9.6e-05 21.6 0.1 3.1 3 1 0 4 4 4 1 FAD binding domain NAD_binding_8 PF13450.6 CAV19701.1 - 8e-05 22.8 2.3 0.0022 18.2 0.2 2.8 3 0 0 3 3 2 1 NAD(P)-binding Rossmann-like domain FAD_binding_3 PF01494.19 CAV19701.1 - 0.00017 21.0 0.9 0.0031 16.8 0.1 2.2 2 0 0 2 2 2 1 FAD binding domain AlaDh_PNT_C PF01262.21 CAV19701.1 - 0.00024 20.5 6.7 0.11 11.8 0.1 3.4 4 0 0 4 4 4 2 Alanine dehydrogenase/PNT, C-terminal domain Thi4 PF01946.17 CAV19701.1 - 0.00067 19.0 0.1 0.0019 17.5 0.1 1.8 1 0 0 1 1 1 1 Thi4 family 3HCDH_N PF02737.18 CAV19701.1 - 0.0084 16.0 1.2 1.3 8.9 0.1 2.4 2 0 0 2 2 2 2 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain DAO PF01266.24 CAV19701.1 - 5.9 6.4 7.9 0.99 8.9 0.4 2.8 2 1 1 3 3 3 0 FAD dependent oxidoreductase 2-oxoacid_dh PF00198.23 CAV19703.1 - 1.8e-79 266.4 0.0 3e-79 265.7 0.0 1.4 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.22 CAV19703.1 - 6.8e-62 205.3 31.6 5.5e-21 74.2 5.3 3.6 3 0 0 3 3 3 3 Biotin-requiring enzyme E3_binding PF02817.17 CAV19703.1 - 2.8e-14 53.2 0.1 9.6e-14 51.4 0.1 2.0 1 0 0 1 1 1 1 e3 binding domain RnfC_N PF13375.6 CAV19703.1 - 3.9e-11 42.8 13.3 0.00096 19.1 0.9 3.7 3 0 0 3 3 3 3 RnfC Barrel sandwich hybrid domain Biotin_lipoyl_2 PF13533.6 CAV19703.1 - 1.3e-09 37.7 5.2 0.035 13.9 0.0 5.7 6 0 0 6 6 6 3 Biotin-lipoyl like HlyD_D23 PF16576.5 CAV19703.1 - 1e-07 31.4 9.8 0.02 14.1 0.1 5.3 3 3 3 6 6 6 3 Barrel-sandwich domain of CusB or HlyD membrane-fusion GCV_H PF01597.19 CAV19703.1 - 2.5e-07 30.6 14.3 0.015 15.2 0.8 3.5 3 0 0 3 3 3 3 Glycine cleavage H-protein HlyD_3 PF13437.6 CAV19703.1 - 0.0027 18.4 18.1 0.3 11.8 0.3 4.9 1 1 3 4 4 4 2 HlyD family secretion protein NQRA PF05896.11 CAV19703.1 - 0.0046 16.4 5.7 0.9 8.9 0.2 3.5 3 0 0 3 3 3 1 Na(+)-translocating NADH-quinone reductase subunit A (NQRA) RNA_pol_inhib PF16857.5 CAV19703.1 - 0.0067 16.2 0.2 21 5.0 0.0 3.6 3 0 0 3 3 3 0 RNA polymerase inhibitor PYNP_C PF07831.13 CAV19703.1 - 0.017 14.8 6.3 53 3.6 0.3 5.8 4 2 2 6 6 6 0 Pyrimidine nucleoside phosphorylase C-terminal domain PDH_E1_M PF17831.1 CAV19705.1 - 1.4e-111 371.6 0.4 2.1e-111 371.0 0.4 1.3 1 0 0 1 1 1 1 Pyruvate dehydrogenase E1 component middle domain Transketolase_N PF00456.21 CAV19705.1 - 1.6e-18 66.8 0.0 2.6e-10 39.8 0.0 2.3 2 0 0 2 2 2 2 Transketolase, thiamine diphosphate binding domain Transketolase_C PF02780.20 CAV19705.1 - 0.036 14.0 0.0 0.11 12.4 0.0 1.8 1 0 0 1 1 1 0 Transketolase, C-terminal domain GntR PF00392.21 CAV19707.1 - 1.8e-25 88.3 0.9 4.5e-25 87.1 0.9 1.7 1 0 0 1 1 1 1 Bacterial regulatory proteins, gntR family FCD PF07729.12 CAV19707.1 - 7e-19 68.5 6.2 1.4e-18 67.5 6.2 1.5 1 0 0 1 1 1 1 FCD domain HTH_DeoR PF08220.12 CAV19707.1 - 0.00085 19.0 0.0 0.002 17.8 0.0 1.6 1 0 0 1 1 1 1 DeoR-like helix-turn-helix domain MarR_2 PF12802.7 CAV19707.1 - 0.00085 19.2 0.1 0.0025 17.7 0.1 1.8 1 0 0 1 1 1 1 MarR family TFIIE_alpha PF02002.17 CAV19707.1 - 0.0019 18.1 0.0 0.23 11.3 0.0 2.5 2 0 0 2 2 2 1 TFIIE alpha subunit HTH_11 PF08279.12 CAV19707.1 - 0.0029 17.5 0.0 0.009 15.9 0.0 1.8 1 0 0 1 1 1 1 HTH domain MarR PF01047.22 CAV19707.1 - 0.0034 17.3 0.0 0.016 15.2 0.0 2.1 2 0 0 2 2 2 1 MarR family TrmB PF01978.19 CAV19707.1 - 0.015 15.1 0.2 0.063 13.2 0.0 2.1 2 0 0 2 2 2 0 Sugar-specific transcriptional regulator TrmB HTH_28 PF13518.6 CAV19707.1 - 0.024 14.8 0.2 0.073 13.2 0.2 1.8 2 0 0 2 2 1 0 Helix-turn-helix domain HTH_24 PF13412.6 CAV19707.1 - 0.042 13.4 0.0 0.081 12.5 0.0 1.5 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding HTH_IclR PF09339.10 CAV19707.1 - 0.06 13.2 0.1 0.18 11.6 0.1 1.9 1 0 0 1 1 1 0 IclR helix-turn-helix domain HTH_29 PF13551.6 CAV19707.1 - 0.064 13.3 0.1 0.17 11.9 0.1 1.7 1 0 0 1 1 1 0 Winged helix-turn helix PaaX PF07848.12 CAV19707.1 - 0.069 13.4 0.2 0.17 12.1 0.2 1.6 1 0 0 1 1 1 0 PaaX-like protein HTH_10 PF04967.12 CAV19707.1 - 0.11 12.4 0.2 0.33 10.8 0.0 1.9 2 0 0 2 2 1 0 HTH DNA binding domain Rrf2 PF02082.20 CAV19707.1 - 0.2 12.0 1.0 0.73 10.2 0.0 2.4 3 0 0 3 3 3 0 Transcriptional regulator Amidase_2 PF01510.25 CAV19712.1 - 1.2e-25 90.4 0.0 1.4e-25 90.2 0.0 1.1 1 0 0 1 1 1 1 N-acetylmuramoyl-L-alanine amidase QRPTase_C PF01729.19 CAV19713.1 - 9.8e-58 194.7 0.3 1.3e-57 194.2 0.3 1.2 1 0 0 1 1 1 1 Quinolinate phosphoribosyl transferase, C-terminal domain QRPTase_N PF02749.16 CAV19713.1 - 2.2e-27 94.9 0.1 9.8e-27 92.8 0.0 2.0 2 1 1 3 3 3 1 Quinolinate phosphoribosyl transferase, N-terminal domain Biotin_lipoyl PF00364.22 CAV19713.1 - 0.0059 16.4 0.0 0.017 15.0 0.0 1.7 1 0 0 1 1 1 1 Biotin-requiring enzyme IMPDH PF00478.25 CAV19713.1 - 0.029 13.4 0.1 0.032 13.2 0.1 1.3 1 0 0 1 1 1 0 IMP dehydrogenase / GMP reductase domain N_methyl PF07963.12 CAV19715.1 - 6.6e-12 44.4 1.2 1.2e-11 43.6 1.2 1.5 1 0 0 1 1 1 1 Prokaryotic N-terminal methylation motif Pilin PF00114.19 CAV19715.1 - 1.1e-08 36.0 0.6 1.3e-08 35.8 0.6 1.1 1 0 0 1 1 1 1 Pilin (bacterial filament) ComP_DUS PF16732.5 CAV19715.1 - 0.039 14.8 0.0 0.052 14.4 0.0 1.2 1 0 0 1 1 1 0 Type IV minor pilin ComP, DNA uptake sequence receptor Coleoptericin PF06286.11 CAV19715.1 - 0.15 12.2 0.1 0.21 11.7 0.1 1.2 1 0 0 1 1 1 0 Coleoptericin T2SSE PF00437.20 CAV19717.1 - 9.7e-88 293.8 0.2 1.6e-87 293.0 0.2 1.3 1 0 0 1 1 1 1 Type II/IV secretion system protein T2SSE_N PF05157.15 CAV19717.1 - 3e-16 59.6 0.0 8.6e-16 58.2 0.0 1.7 1 0 0 1 1 1 1 Type II secretion system (T2SS), protein E, N-terminal domain AAA_30 PF13604.6 CAV19717.1 - 0.0052 16.5 0.0 0.012 15.4 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 CAV19717.1 - 0.013 15.8 0.1 0.055 13.7 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_11 PF13086.6 CAV19717.1 - 0.046 13.5 0.1 0.099 12.4 0.1 1.6 1 1 1 2 2 2 0 AAA domain PELOTA_1 PF15608.6 CAV19717.1 - 0.058 13.3 0.0 0.16 11.9 0.0 1.7 1 0 0 1 1 1 0 PELOTA RNA binding domain PhoH PF02562.16 CAV19717.1 - 0.061 12.8 0.0 0.13 11.7 0.0 1.4 1 0 0 1 1 1 0 PhoH-like protein AAA_16 PF13191.6 CAV19717.1 - 0.076 13.4 0.5 0.45 10.9 0.0 2.4 2 2 0 2 2 2 0 AAA ATPase domain AAA_7 PF12775.7 CAV19717.1 - 0.11 12.0 0.1 0.19 11.2 0.1 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_29 PF13555.6 CAV19717.1 - 0.16 11.7 0.1 0.38 10.5 0.1 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain T2SSF PF00482.23 CAV19719.1 - 1.5e-59 199.4 3.1 2.5e-31 108.2 0.5 2.4 2 0 0 2 2 2 2 Type II secretion system (T2SS), protein F Tsc35 PF15079.6 CAV19719.1 - 0.22 11.1 2.2 0.32 10.5 1.1 1.7 2 0 0 2 2 2 0 Testis-specific protein 35 DiS_P_DiS PF06750.13 CAV19721.1 - 2e-33 114.4 1.6 3.8e-33 113.5 1.6 1.5 1 0 0 1 1 1 1 Bacterial Peptidase A24 N-terminal domain Peptidase_A24 PF01478.18 CAV19721.1 - 1.6e-26 92.8 14.2 1.6e-26 92.8 14.2 2.0 3 0 0 3 3 3 1 Type IV leader peptidase family DZR PF12773.7 CAV19721.1 - 0.098 12.7 0.1 0.17 12.0 0.1 1.3 1 0 0 1 1 1 0 Double zinc ribbon CoaE PF01121.20 CAV19723.1 - 3.6e-30 105.0 0.1 4.2e-30 104.7 0.1 1.0 1 0 0 1 1 1 1 Dephospho-CoA kinase PRK PF00485.18 CAV19723.1 - 0.0013 18.5 0.0 0.0013 18.5 0.0 1.1 1 0 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family AAA_28 PF13521.6 CAV19723.1 - 0.0034 17.6 0.0 0.0039 17.4 0.0 1.1 1 0 0 1 1 1 1 AAA domain dNK PF01712.19 CAV19723.1 - 0.007 16.2 0.0 0.0073 16.2 0.0 1.2 1 0 0 1 1 1 1 Deoxynucleoside kinase AAA_18 PF13238.6 CAV19723.1 - 0.017 15.7 0.0 0.017 15.7 0.0 1.2 1 0 0 1 1 1 0 AAA domain AAA_17 PF13207.6 CAV19723.1 - 0.034 14.6 0.0 0.037 14.4 0.0 1.1 1 0 0 1 1 1 0 AAA domain Cytidylate_kin2 PF13189.6 CAV19723.1 - 0.049 13.8 0.0 0.049 13.8 0.0 1.1 1 0 0 1 1 1 0 Cytidylate kinase-like family SKI PF01202.22 CAV19723.1 - 0.091 12.9 0.0 0.097 12.8 0.0 1.2 1 0 0 1 1 1 0 Shikimate kinase Zeta_toxin PF06414.12 CAV19723.1 - 0.14 11.4 0.0 0.16 11.3 0.0 1.2 1 0 0 1 1 1 0 Zeta toxin CoaE PF01121.20 CAV19725.1 - 3.2e-17 62.8 3.8 3.8e-17 62.5 3.8 1.1 1 0 0 1 1 1 1 Dephospho-CoA kinase AAA_31 PF13614.6 CAV19725.1 - 0.045 13.7 0.6 0.045 13.7 0.6 1.0 1 0 0 1 1 1 0 AAA domain ZapD PF07072.11 CAV19727.1 - 1.3e-75 253.8 1.1 1.5e-75 253.6 1.1 1.0 1 0 0 1 1 1 1 Cell division protein EF-hand_3 PF09069.11 CAV19727.1 - 0.03 14.7 0.3 0.16 12.4 0.0 2.1 1 1 1 2 2 2 0 EF-hand YacG PF03884.14 CAV19729.1 - 3.9e-23 80.9 3.0 4.6e-23 80.7 3.0 1.1 1 0 0 1 1 1 1 DNA gyrase inhibitor YacG zf-MYND PF01753.18 CAV19729.1 - 0.013 15.6 0.7 0.023 14.8 0.7 1.4 1 1 0 1 1 1 0 MYND finger zf-HIT PF04438.16 CAV19729.1 - 0.017 15.0 1.8 0.03 14.2 1.8 1.3 1 1 0 1 1 1 0 HIT zinc finger Ribosomal_L19 PF01245.20 CAV19731.1 - 1.9e-50 169.4 2.2 2.1e-50 169.3 2.2 1.0 1 0 0 1 1 1 1 Ribosomal protein L19 tRNA_m1G_MT PF01746.21 CAV19733.1 - 9.7e-69 231.0 0.0 1.1e-68 230.8 0.0 1.0 1 0 0 1 1 1 1 tRNA (Guanine-1)-methyltransferase RimM PF01782.18 CAV19735.1 - 5.4e-25 87.4 0.0 8.1e-25 86.9 0.0 1.3 1 0 0 1 1 1 1 RimM N-terminal domain PRC PF05239.16 CAV19735.1 - 2e-13 50.2 0.2 4.4e-13 49.1 0.2 1.5 1 0 0 1 1 1 1 PRC-barrel domain Ribosomal_S16 PF00886.19 CAV19737.1 - 2.5e-23 81.9 0.0 3e-23 81.6 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein S16 SRP54 PF00448.22 CAV19739.1 - 4e-74 248.5 0.4 9.6e-74 247.3 0.4 1.7 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain SRP_SPB PF02978.19 CAV19739.1 - 3.2e-33 114.3 10.5 3.2e-33 114.3 10.5 3.5 4 0 0 4 4 2 1 Signal peptide binding domain SRP54_N PF02881.19 CAV19739.1 - 1.7e-21 76.2 0.9 1.7e-21 76.2 0.9 3.4 5 0 0 5 5 4 1 SRP54-type protein, helical bundle domain CbiA PF01656.23 CAV19739.1 - 5.8e-07 29.6 0.0 3.2e-06 27.2 0.0 2.3 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain Zeta_toxin PF06414.12 CAV19739.1 - 7.2e-06 25.4 1.0 1.3e-05 24.5 0.0 1.9 3 0 0 3 3 3 1 Zeta toxin AAA_22 PF13401.6 CAV19739.1 - 0.0001 22.6 0.0 0.00032 21.0 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 CAV19739.1 - 0.00036 20.3 2.2 0.0004 20.2 0.4 2.0 2 0 0 2 2 2 1 AAA domain cobW PF02492.19 CAV19739.1 - 0.00044 19.9 1.8 0.0056 16.3 1.8 2.4 1 1 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain KTI12 PF08433.10 CAV19739.1 - 0.0041 16.6 2.8 0.22 10.9 0.1 2.3 2 0 0 2 2 2 1 Chromatin associated protein KTI12 Mg_chelatase PF01078.21 CAV19739.1 - 0.0064 15.9 0.1 0.011 15.1 0.1 1.3 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_24 PF13479.6 CAV19739.1 - 0.0071 16.1 0.1 0.021 14.6 0.1 1.8 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 CAV19739.1 - 0.0071 16.5 0.0 0.018 15.2 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_31 PF13614.6 CAV19739.1 - 0.012 15.5 0.4 0.012 15.5 0.4 2.6 2 1 1 3 3 3 0 AAA domain T2SSE PF00437.20 CAV19739.1 - 0.013 14.6 0.0 0.034 13.2 0.0 1.7 1 0 0 1 1 1 0 Type II/IV secretion system protein APS_kinase PF01583.20 CAV19739.1 - 0.022 14.7 0.0 0.053 13.4 0.0 1.6 1 0 0 1 1 1 0 Adenylylsulphate kinase VirC1 PF07015.11 CAV19739.1 - 0.059 12.7 0.0 0.13 11.6 0.0 1.6 1 0 0 1 1 1 0 VirC1 protein AAA_26 PF13500.6 CAV19739.1 - 0.065 13.1 0.0 0.12 12.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain Rad17 PF03215.15 CAV19739.1 - 0.071 13.0 0.0 0.21 11.5 0.0 1.8 1 0 0 1 1 1 0 Rad17 P-loop domain Helicase_RecD PF05127.14 CAV19739.1 - 0.085 12.7 0.4 0.29 11.0 0.1 2.0 2 0 0 2 2 2 0 Helicase AAA_16 PF13191.6 CAV19739.1 - 0.1 13.0 0.0 0.22 11.9 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain AAA_18 PF13238.6 CAV19739.1 - 0.12 13.0 0.4 0.6 10.7 0.0 2.5 3 0 0 3 3 3 0 AAA domain MMR_HSR1 PF01926.23 CAV19739.1 - 0.3 11.2 1.8 1.8 8.7 0.7 2.8 2 1 0 2 2 2 0 50S ribosome-binding GTPase Thymidylate_kin PF02223.17 CAV19739.1 - 0.42 10.3 2.7 0.56 9.9 0.2 2.2 2 0 0 2 2 2 0 Thymidylate kinase ArsA_ATPase PF02374.15 CAV19739.1 - 6.3 5.9 16.1 0.46 9.6 0.2 4.1 4 0 0 4 4 4 0 Anion-transporting ATPase DUF3867 PF12983.7 CAV19739.1 - 8 6.5 9.1 22 5.0 8.7 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF3867) Cytochrom_C_asm PF01578.20 CAV19740.1 - 5.6e-44 150.5 21.7 5.6e-44 150.5 21.7 1.4 2 0 0 2 2 2 1 Cytochrome C assembly protein DUF21 PF01595.20 CAV19742.1 - 1.5e-48 164.8 4.1 2.2e-48 164.3 4.1 1.2 1 0 0 1 1 1 1 Cyclin M transmembrane N-terminal domain CorC_HlyC PF03471.17 CAV19742.1 - 2.8e-16 59.3 0.0 8.2e-16 57.8 0.0 1.8 1 0 0 1 1 1 1 Transporter associated domain CBS PF00571.28 CAV19742.1 - 5.9e-06 26.6 0.8 0.0012 19.2 0.0 2.7 2 0 0 2 2 2 2 CBS domain LuxS PF02664.15 CAV19744.1 - 2.5e-60 202.6 0.0 2.8e-60 202.4 0.0 1.0 1 0 0 1 1 1 1 S-Ribosylhomocysteinase (LuxS) Glu_cys_ligase PF04262.14 CAV19747.1 - 5.4e-167 555.1 0.0 7.1e-167 554.7 0.0 1.1 1 0 0 1 1 1 1 Glutamate-cysteine ligase Peptidase_M16_C PF05193.21 CAV19749.1 - 2.9e-55 187.1 0.3 3.2e-25 89.2 0.0 4.2 4 0 0 4 4 4 2 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 CAV19749.1 - 7.9e-33 113.5 1.0 7.8e-18 64.9 0.0 2.8 3 0 0 3 3 3 2 Insulinase (Peptidase family M16) SNARE_assoc PF09335.11 CAV19751.1 - 2.9e-11 43.9 3.2 4.5e-11 43.3 3.1 1.4 1 1 0 1 1 1 1 SNARE associated Golgi protein ADH_zinc_N_2 PF13602.6 CAV19753.1 - 7e-20 72.4 0.0 1.4e-19 71.5 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.26 CAV19753.1 - 3.7e-13 49.6 0.3 6.4e-13 48.8 0.3 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 CAV19753.1 - 5.2e-10 39.2 0.1 1.1e-07 31.6 0.0 3.7 3 1 1 4 4 4 1 Alcohol dehydrogenase GroES-like domain ADH_N_2 PF16884.5 CAV19753.1 - 0.0001 22.2 0.0 0.00023 21.0 0.0 1.5 1 0 0 1 1 1 1 N-terminal domain of oxidoreductase AlaDh_PNT_C PF01262.21 CAV19753.1 - 0.025 13.9 2.3 0.044 13.1 2.3 1.4 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain RTC4 PF14474.6 CAV19753.1 - 0.079 13.1 0.0 0.18 11.9 0.0 1.6 2 0 0 2 2 2 0 RTC4-like domain OAD_beta PF03977.13 CAV19755.1 - 1e-158 527.9 25.7 1.2e-158 527.7 25.7 1.0 1 0 0 1 1 1 1 Na+-transporting oxaloacetate decarboxylase beta subunit PYC_OADA PF02436.18 CAV19757.1 - 1.6e-60 204.3 0.1 2.9e-60 203.4 0.1 1.4 1 0 0 1 1 1 1 Conserved carboxylase domain HMGL-like PF00682.19 CAV19757.1 - 1.4e-57 195.2 0.0 2.1e-57 194.7 0.0 1.2 1 0 0 1 1 1 1 HMGL-like Biotin_lipoyl PF00364.22 CAV19757.1 - 3.2e-17 62.1 0.4 7.6e-17 60.9 0.4 1.7 1 0 0 1 1 1 1 Biotin-requiring enzyme Biotin_lipoyl_2 PF13533.6 CAV19757.1 - 2.8e-08 33.5 0.9 0.002 17.9 0.1 2.9 1 1 1 2 2 2 2 Biotin-lipoyl like HlyD_3 PF13437.6 CAV19757.1 - 0.00025 21.7 3.2 0.013 16.1 0.1 3.3 3 0 0 3 3 3 1 HlyD family secretion protein HlyD_D23 PF16576.5 CAV19757.1 - 0.00082 18.6 0.1 0.026 13.7 0.0 2.3 1 1 1 2 2 2 1 Barrel-sandwich domain of CusB or HlyD membrane-fusion PTS_EIIA_1 PF00358.20 CAV19757.1 - 0.09 12.5 0.1 1.9 8.3 0.0 2.3 1 1 1 2 2 2 0 phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1 GCV_H PF01597.19 CAV19757.1 - 0.09 12.7 0.8 0.3 11.0 0.2 2.1 1 1 1 2 2 2 0 Glycine cleavage H-protein OAD_gamma PF04277.13 CAV19759.1 - 1.7e-20 73.4 0.5 2.1e-20 73.1 0.5 1.1 1 0 0 1 1 1 1 Oxaloacetate decarboxylase, gamma chain CsrA PF02599.16 CAV19760.1 - 1.9e-26 91.8 1.9 2.2e-26 91.6 1.9 1.1 1 0 0 1 1 1 1 Global regulator protein family S1 PF00575.23 CAV19760.1 - 0.023 15.0 0.9 0.11 12.9 0.6 1.8 1 1 1 2 2 2 0 S1 RNA binding domain AA_kinase PF00696.28 CAV19762.1 - 2.8e-51 174.5 1.0 4e-51 173.9 1.0 1.2 1 0 0 1 1 1 1 Amino acid kinase family PI-PLC-C1 PF16670.5 CAV19762.1 - 0.036 13.1 0.0 0.077 12.1 0.0 1.5 2 0 0 2 2 2 0 Phosphoinositide phospholipase C, Ca2+-dependent EIIA-man PF03610.16 CAV19762.1 - 0.044 14.0 1.0 11 6.3 0.1 2.6 2 0 0 2 2 2 0 PTS system fructose IIA component I_LWEQ PF01608.17 CAV19762.1 - 0.1 12.8 1.2 0.14 12.4 0.3 1.6 2 0 0 2 2 2 0 I/LWEQ domain tRNA-synt_2c PF01411.19 CAV19764.1 - 6.6e-227 754.4 0.1 1.1e-226 753.7 0.1 1.3 1 0 0 1 1 1 1 tRNA synthetases class II (A) DHHA1 PF02272.19 CAV19764.1 - 3.2e-26 92.4 9.1 3.2e-26 92.4 9.1 2.2 2 0 0 2 2 2 1 DHHA1 domain tRNA_SAD PF07973.14 CAV19764.1 - 2e-18 66.2 0.8 5.4e-18 64.8 0.2 2.2 2 0 0 2 2 2 1 Threonyl and Alanyl tRNA synthetase second additional domain TraH_2 PF06871.11 CAV19764.1 - 0.00063 19.4 0.0 0.0022 17.7 0.0 1.8 2 0 0 2 2 2 1 TraH_2 Flagellar_rod PF05149.12 CAV19764.1 - 0.47 9.9 7.5 0.022 14.3 1.2 2.0 2 0 0 2 2 2 0 Paraflagellar rod protein DivIC PF04977.15 CAV19764.1 - 0.72 9.7 3.1 3.1 7.6 3.1 2.1 1 0 0 1 1 1 0 Septum formation initiator Alpha-amylase PF00128.24 CAV19767.1 - 2.9e-60 204.6 6.8 4.2e-60 204.1 6.8 1.3 1 0 0 1 1 1 1 Alpha amylase, catalytic domain Alpha-amylase_C PF02806.18 CAV19767.1 - 2.2e-06 28.0 1.2 7.1e-06 26.4 0.2 2.4 2 0 0 2 2 2 1 Alpha amylase, C-terminal all-beta domain Malt_amylase_C PF16657.5 CAV19767.1 - 0.0065 16.6 0.0 0.013 15.6 0.0 1.6 1 0 0 1 1 1 1 Maltogenic Amylase, C-terminal domain Bac_A_amyl_C PF18612.1 CAV19767.1 - 0.02 14.7 1.2 0.038 13.8 1.2 1.5 1 0 0 1 1 1 0 Bacterial Alpha amylase C-terminal domain ABC_tran PF00005.27 CAV19769.1 - 2.1e-29 102.8 0.0 4.5e-29 101.7 0.0 1.5 1 0 0 1 1 1 1 ABC transporter TOBE_2 PF08402.10 CAV19769.1 - 1.4e-10 41.2 0.0 5.7e-10 39.2 0.0 2.1 2 0 0 2 2 2 1 TOBE domain OB_MalK PF17912.1 CAV19769.1 - 2.2e-10 41.2 0.0 7.5e-10 39.5 0.0 2.0 1 0 0 1 1 1 1 MalK OB fold domain TOBE PF03459.17 CAV19769.1 - 6.7e-06 26.3 0.0 7e-05 23.0 0.0 2.5 2 0 0 2 2 2 1 TOBE domain AAA_21 PF13304.6 CAV19769.1 - 0.00042 20.2 0.0 0.16 11.7 0.0 2.2 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system Rad17 PF03215.15 CAV19769.1 - 0.018 15.0 0.0 0.029 14.3 0.0 1.4 1 0 0 1 1 1 0 Rad17 P-loop domain RsgA_GTPase PF03193.16 CAV19769.1 - 0.024 14.6 0.0 0.045 13.7 0.0 1.4 1 0 0 1 1 1 0 RsgA GTPase Hexapep PF00132.24 CAV19773.1 - 7.9e-24 82.5 34.4 4.2e-08 32.6 2.9 6.2 5 1 1 6 6 6 5 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 CAV19773.1 - 1.6e-07 30.9 30.7 0.0001 22.0 6.0 5.8 3 2 3 6 6 6 4 Hexapeptide repeat of succinyl-transferase AHJR-like PF18743.1 CAV19773.1 - 0.15 11.7 0.0 0.25 10.9 0.0 1.3 1 0 0 1 1 1 0 REase_AHJR-like CymA PF16941.5 CAV19774.1 - 1.5e-208 691.9 19.6 1.7e-208 691.7 19.6 1.0 1 0 0 1 1 1 1 Putative cyclodextrin porin SBP_bac_8 PF13416.6 CAV19776.1 - 1.7e-31 110.1 0.6 1.7e-31 110.1 0.6 1.4 2 0 0 2 2 2 1 Bacterial extracellular solute-binding protein SBP_bac_1 PF01547.25 CAV19776.1 - 4.4e-25 89.3 2.0 7.5e-25 88.5 2.0 1.3 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein BPD_transp_1 PF00528.22 CAV19778.1 - 2.2e-24 86.2 14.4 2.2e-24 86.2 14.4 3.0 1 1 2 3 3 3 1 Binding-protein-dependent transport system inner membrane component TM_PBP2_N PF16296.5 CAV19778.1 - 0.0033 17.5 0.5 0.0072 16.4 0.0 1.8 2 0 0 2 2 2 1 N-terminal of TM subunit in PBP-dependent ABC transporters BPD_transp_1 PF00528.22 CAV19779.1 - 2.1e-15 57.0 19.5 2.1e-15 57.0 19.5 2.0 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component Alpha-amylase PF00128.24 CAV19781.1 - 5.4e-84 282.6 1.7 8e-84 282.1 1.7 1.2 1 0 0 1 1 1 1 Alpha amylase, catalytic domain Alpha-amylase_N PF02903.14 CAV19781.1 - 1.5e-24 86.5 0.0 5.6e-24 84.6 0.0 2.0 2 0 0 2 2 2 1 Alpha amylase, N-terminal ig-like domain Glyco_hydro_66 PF13199.6 CAV19781.1 - 0.0093 14.7 2.2 0.014 14.0 2.2 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 66 LBP_C PF17386.2 CAV19781.1 - 0.017 15.0 0.0 0.053 13.4 0.0 1.8 1 0 0 1 1 1 0 Lacto-N-biose phosphorylase C-terminal domain GHL6 PF14871.6 CAV19781.1 - 0.041 14.0 0.0 0.13 12.4 0.0 1.8 2 0 0 2 2 2 0 Hypothetical glycosyl hydrolase 6 Glyco_hydro_42C PF08533.10 CAV19781.1 - 0.067 12.9 0.0 0.16 11.7 0.0 1.7 1 0 0 1 1 1 0 Beta-galactosidase C-terminal domain ROK PF00480.20 CAV19783.1 - 6.7e-21 75.0 0.0 1.8e-18 67.1 0.0 2.0 2 0 0 2 2 2 2 ROK family TrmB PF01978.19 CAV19785.1 - 3.5e-15 55.6 0.0 7.1e-15 54.7 0.0 1.5 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB Regulator_TrmB PF11495.8 CAV19785.1 - 3.9e-08 32.8 0.0 5.6e-08 32.3 0.0 1.3 1 0 0 1 1 1 1 Archaeal transcriptional regulator TrmB HTH_11 PF08279.12 CAV19785.1 - 0.00013 21.8 0.0 0.00032 20.6 0.0 1.6 1 0 0 1 1 1 1 HTH domain HTH_7 PF02796.15 CAV19785.1 - 0.002 18.2 0.1 0.0045 17.0 0.1 1.6 1 0 0 1 1 1 1 Helix-turn-helix domain of resolvase Mga PF05043.13 CAV19785.1 - 0.0071 16.9 1.3 1.8 9.2 0.0 2.5 2 0 0 2 2 2 2 Mga helix-turn-helix domain HTH_36 PF13730.6 CAV19785.1 - 0.028 14.4 0.0 0.29 11.1 0.1 2.4 2 1 0 2 2 2 0 Helix-turn-helix domain HTH_46 PF15977.5 CAV19785.1 - 0.036 14.1 0.2 0.13 12.3 0.0 2.0 2 0 0 2 2 2 0 Winged helix-turn-helix DNA binding HTH_24 PF13412.6 CAV19785.1 - 0.094 12.3 0.0 0.18 11.4 0.0 1.5 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding MarR PF01047.22 CAV19785.1 - 0.12 12.3 0.1 0.69 9.9 0.0 2.3 3 0 0 3 3 3 0 MarR family RecA PF00154.21 CAV19787.1 - 5.6e-142 471.8 2.5 6.7e-142 471.6 2.5 1.1 1 0 0 1 1 1 1 recA bacterial DNA recombination protein Rad51 PF08423.11 CAV19787.1 - 1e-11 44.6 0.4 2.9e-11 43.1 0.4 1.6 1 1 0 1 1 1 1 Rad51 ATPase PF06745.13 CAV19787.1 - 5.4e-11 42.3 0.3 3.1e-09 36.5 0.3 2.7 1 1 0 1 1 1 1 KaiC AAA_24 PF13479.6 CAV19787.1 - 5.4e-06 26.3 0.0 8.4e-06 25.6 0.0 1.3 1 0 0 1 1 1 1 AAA domain ATPase_2 PF01637.18 CAV19787.1 - 9.5e-05 22.4 0.0 0.00019 21.5 0.0 1.5 1 1 0 1 1 1 1 ATPase domain predominantly from Archaea AAA_25 PF13481.6 CAV19787.1 - 0.0016 18.1 1.1 0.071 12.7 1.1 2.5 1 1 0 1 1 1 1 AAA domain AAA PF00004.29 CAV19787.1 - 0.0072 16.7 0.1 0.014 15.8 0.1 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 CAV19787.1 - 0.0086 16.5 0.0 0.014 15.7 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain PAXNEB PF05625.11 CAV19787.1 - 0.019 14.1 0.6 0.03 13.5 0.6 1.2 1 0 0 1 1 1 0 PAXNEB protein AAA_22 PF13401.6 CAV19787.1 - 0.026 14.8 0.0 0.049 13.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain CbiA PF01656.23 CAV19787.1 - 0.031 14.3 0.5 0.15 12.1 0.5 2.1 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain CobU PF02283.16 CAV19787.1 - 0.069 12.7 0.0 0.12 11.9 0.0 1.4 1 0 0 1 1 1 0 Cobinamide kinase / cobinamide phosphate guanyltransferase AAA_28 PF13521.6 CAV19787.1 - 0.15 12.3 0.0 0.35 11.1 0.0 1.7 1 0 0 1 1 1 0 AAA domain ATP_bind_1 PF03029.17 CAV19787.1 - 0.17 11.7 0.0 0.27 11.0 0.0 1.4 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein AAA_35 PF14516.6 CAV19787.1 - 0.2 10.5 0.0 0.33 9.7 0.0 1.2 1 0 0 1 1 1 0 AAA-like domain CinA PF02464.17 CAV19789.1 - 1.6e-56 190.1 0.7 1.9e-56 189.9 0.7 1.1 1 0 0 1 1 1 1 Competence-damaged protein MutS_V PF00488.21 CAV19791.1 - 3.7e-89 297.7 1.8 1.7e-88 295.6 0.3 2.2 2 0 0 2 2 2 1 MutS domain V MutS_I PF01624.20 CAV19791.1 - 5.8e-42 142.5 0.0 1.4e-41 141.3 0.0 1.7 1 0 0 1 1 1 1 MutS domain I MutS_III PF05192.18 CAV19791.1 - 1.6e-41 142.7 0.9 3e-41 141.8 0.9 1.5 1 0 0 1 1 1 1 MutS domain III MutS_II PF05188.17 CAV19791.1 - 6.3e-32 110.7 0.0 1.9e-31 109.1 0.0 1.9 2 0 0 2 2 2 1 MutS domain II MutS_IV PF05190.18 CAV19791.1 - 1.4e-30 105.5 0.0 4.2e-30 103.9 0.0 1.9 1 0 0 1 1 1 1 MutS family domain IV Snapin_Pallidin PF14712.6 CAV19791.1 - 0.051 14.0 2.0 0.8 10.2 0.1 3.6 2 2 2 4 4 4 0 Snapin/Pallidin AAA_14 PF13173.6 CAV19791.1 - 0.15 12.1 0.0 0.4 10.7 0.0 1.7 1 0 0 1 1 1 0 AAA domain Sigma70_r3 PF04539.16 CAV19793.1 - 4.7e-23 81.1 0.9 1.3e-20 73.3 0.3 2.5 2 0 0 2 2 2 2 Sigma-70 region 3 Sigma70_r2 PF04542.14 CAV19793.1 - 4.2e-20 71.3 0.1 7.5e-20 70.5 0.1 1.4 1 0 0 1 1 1 1 Sigma-70 region 2 Sigma70_r4 PF04545.16 CAV19793.1 - 6.2e-19 67.3 3.9 6.8e-17 60.7 1.8 3.0 3 0 0 3 3 3 2 Sigma-70, region 4 Sigma70_r1_2 PF00140.20 CAV19793.1 - 1.9e-12 47.0 1.1 4.3e-12 45.8 0.2 2.2 2 0 0 2 2 2 1 Sigma-70 factor, region 1.2 Peptidase_M23 PF01551.22 CAV19795.1 - 3.8e-31 107.2 1.2 3.8e-31 107.2 1.2 2.0 3 0 0 3 3 3 1 Peptidase family M23 LysM PF01476.20 CAV19795.1 - 4.9e-12 45.7 0.2 2.6e-11 43.4 0.0 2.1 2 0 0 2 2 2 1 LysM domain Biotin_lipoyl_2 PF13533.6 CAV19795.1 - 0.00015 21.5 0.0 0.027 14.3 0.0 2.7 2 0 0 2 2 2 2 Biotin-lipoyl like PCMT PF01135.19 CAV19796.1 - 6.7e-71 238.4 0.0 7.9e-71 238.1 0.0 1.0 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_31 PF13847.6 CAV19796.1 - 1.5e-08 34.6 0.0 2.2e-08 34.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CAV19796.1 - 4.5e-06 26.6 0.0 7.3e-06 25.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CAV19796.1 - 6.3e-06 26.8 0.0 9.9e-06 26.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain RrnaAD PF00398.20 CAV19796.1 - 3.6e-05 23.0 0.0 5.1e-05 22.5 0.0 1.2 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Methyltransf_11 PF08241.12 CAV19796.1 - 0.00015 22.4 0.0 0.00027 21.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain DREV PF05219.12 CAV19796.1 - 0.0007 18.8 0.0 0.00097 18.3 0.0 1.2 1 0 0 1 1 1 1 DREV methyltransferase CMAS PF02353.20 CAV19796.1 - 0.012 14.9 0.0 0.016 14.6 0.0 1.1 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Methyltr_RsmB-F PF01189.17 CAV19796.1 - 0.012 15.2 0.0 0.02 14.6 0.0 1.5 1 1 0 1 1 1 0 16S rRNA methyltransferase RsmB/F Methyltransf_18 PF12847.7 CAV19796.1 - 0.033 14.1 0.0 0.052 13.5 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain NodS PF05401.11 CAV19796.1 - 0.041 13.5 0.0 0.057 13.0 0.0 1.1 1 0 0 1 1 1 0 Nodulation protein S (NodS) GCD14 PF08704.10 CAV19796.1 - 0.054 13.2 0.0 0.067 12.9 0.0 1.2 1 0 0 1 1 1 0 tRNA methyltransferase complex GCD14 subunit Methyltransf_32 PF13679.6 CAV19796.1 - 0.059 13.4 0.0 0.092 12.7 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_12 PF08242.12 CAV19796.1 - 0.082 13.7 0.0 0.16 12.8 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain MTS PF05175.14 CAV19796.1 - 0.094 12.3 0.0 0.21 11.2 0.0 1.6 1 1 0 1 1 1 0 Methyltransferase small domain DUF938 PF06080.12 CAV19796.1 - 0.12 12.1 0.0 0.19 11.4 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF938) SurE PF01975.17 CAV19798.1 - 1.2e-60 204.7 0.1 1.4e-60 204.4 0.1 1.1 1 0 0 1 1 1 1 Survival protein SurE TruD PF01142.18 CAV19800.1 - 7.5e-66 222.7 0.0 1.8e-40 139.0 0.0 2.0 1 1 1 2 2 2 2 tRNA pseudouridine synthase D (TruD) gag-asp_proteas PF13975.6 CAV19800.1 - 0.078 13.5 0.0 8.7 7.0 0.0 2.5 2 0 0 2 2 2 0 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 CAV19800.1 - 0.14 12.8 0.0 5.5 7.7 0.0 2.5 2 0 0 2 2 2 0 Aspartyl protease YgbB PF02542.16 CAV19802.1 - 4.3e-66 222.0 0.2 4.8e-66 221.8 0.2 1.0 1 0 0 1 1 1 1 YgbB family IspD PF01128.19 CAV19804.1 - 2.5e-80 269.4 0.0 2.8e-80 269.2 0.0 1.0 1 0 0 1 1 1 1 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase NTP_transf_3 PF12804.7 CAV19804.1 - 1.4e-13 51.5 0.2 1.7e-13 51.2 0.2 1.2 1 0 0 1 1 1 1 MobA-like NTP transferase domain CTP_transf_3 PF02348.19 CAV19804.1 - 5.5e-07 29.7 0.0 6.3e-07 29.5 0.0 1.1 1 0 0 1 1 1 1 Cytidylyltransferase NTP_transferase PF00483.23 CAV19804.1 - 0.12 11.9 0.0 0.13 11.8 0.0 1.2 1 0 0 1 1 1 0 Nucleotidyl transferase DivIC PF04977.15 CAV19806.1 - 2e-27 94.8 0.1 2.3e-27 94.6 0.1 1.1 1 0 0 1 1 1 1 Septum formation initiator DUF4131 PF13567.6 CAV19806.1 - 0.17 11.5 0.0 0.18 11.5 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) Enolase_C PF00113.22 CAV19808.1 - 3e-136 453.5 2.8 3.7e-136 453.2 2.8 1.1 1 0 0 1 1 1 1 Enolase, C-terminal TIM barrel domain Enolase_N PF03952.16 CAV19808.1 - 4.3e-57 191.9 0.2 9.7e-57 190.8 0.2 1.6 1 0 0 1 1 1 1 Enolase, N-terminal domain MR_MLE_C PF13378.6 CAV19808.1 - 0.00018 21.1 0.0 0.00036 20.2 0.0 1.5 1 0 0 1 1 1 1 Enolase C-terminal domain-like MAAL_C PF07476.11 CAV19808.1 - 0.0011 18.1 0.6 0.0039 16.4 0.1 1.9 2 0 0 2 2 2 1 Methylaspartate ammonia-lyase C-terminus CTP_synth_N PF06418.14 CAV19811.1 - 3.8e-124 413.2 0.1 5.5e-124 412.7 0.1 1.2 1 0 0 1 1 1 1 CTP synthase N-terminus GATase PF00117.28 CAV19811.1 - 4e-63 212.6 0.0 8.9e-63 211.5 0.0 1.6 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.13 CAV19811.1 - 8.6e-08 32.2 1.0 1.1e-06 28.6 0.3 2.5 2 1 0 2 2 2 1 Peptidase C26 CbiA PF01656.23 CAV19811.1 - 0.00086 19.4 0.0 0.0013 18.8 0.0 1.7 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain MazG PF03819.17 CAV19812.1 - 5.1e-36 122.7 1.3 4e-27 94.2 0.0 2.3 2 0 0 2 2 2 2 MazG nucleotide pyrophosphohydrolase domain PRA-PH PF01503.17 CAV19812.1 - 1.1e-07 32.1 0.5 0.011 16.2 0.0 2.7 3 0 0 3 3 3 2 Phosphoribosyl-ATP pyrophosphohydrolase PMC2NT PF08066.12 CAV19812.1 - 0.00045 20.8 0.5 0.037 14.7 0.0 3.1 3 1 0 3 3 3 1 PMC2NT (NUC016) domain MazG-like PF12643.7 CAV19812.1 - 0.006 16.8 1.1 1.3 9.4 0.0 3.4 3 1 1 4 4 4 1 MazG-like family DUF5344 PF17279.2 CAV19812.1 - 0.25 12.0 2.2 22 5.7 0.0 3.2 3 0 0 3 3 3 0 Family of unknown function (DUF5344) Pup PF05639.11 CAV19812.1 - 0.93 10.4 5.4 1.3 10.0 0.4 3.0 3 0 0 3 3 3 0 Pup-like protein RelA_SpoT PF04607.17 CAV19814.1 - 4.9e-36 123.6 0.0 1.1e-35 122.4 0.0 1.7 1 0 0 1 1 1 1 Region found in RelA / SpoT proteins HD_4 PF13328.6 CAV19814.1 - 7e-35 120.1 0.2 1.4e-34 119.1 0.2 1.5 1 0 0 1 1 1 1 HD domain TGS PF02824.21 CAV19814.1 - 1.5e-21 76.2 0.0 3.8e-20 71.7 0.0 2.8 2 0 0 2 2 2 1 TGS domain ACT_4 PF13291.6 CAV19814.1 - 7.3e-15 55.3 1.9 1.7e-14 54.1 1.9 1.7 1 0 0 1 1 1 1 ACT domain ACT PF01842.25 CAV19814.1 - 0.00033 20.4 0.1 0.00096 18.9 0.1 1.9 1 0 0 1 1 1 1 ACT domain DUF1835 PF08874.10 CAV19814.1 - 0.019 15.2 0.1 11 6.3 0.1 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF1835) XkdW PF09636.10 CAV19814.1 - 0.088 12.9 0.0 0.29 11.2 0.0 1.8 1 0 0 1 1 1 0 XkdW protein tRNA_U5-meth_tr PF05958.11 CAV19816.1 - 9.2e-33 113.7 0.0 1.4e-31 109.8 0.0 2.5 1 1 0 1 1 1 1 tRNA (Uracil-5-)-methyltransferase Methyltransf_31 PF13847.6 CAV19816.1 - 2.9e-14 53.1 0.0 6.4e-14 52.0 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain TRAM PF01938.20 CAV19816.1 - 2e-12 46.9 0.0 4.3e-12 45.8 0.0 1.5 1 0 0 1 1 1 1 TRAM domain Methyltransf_25 PF13649.6 CAV19816.1 - 1.3e-08 35.4 0.0 5.2e-08 33.5 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Cons_hypoth95 PF03602.15 CAV19816.1 - 1.6e-05 24.6 0.1 3.3e-05 23.6 0.1 1.5 1 0 0 1 1 1 1 Conserved hypothetical protein 95 Met_10 PF02475.16 CAV19816.1 - 3.1e-05 23.8 0.0 5.1e-05 23.1 0.0 1.4 1 0 0 1 1 1 1 Met-10+ like-protein MTS PF05175.14 CAV19816.1 - 3.7e-05 23.4 0.0 0.0001 21.9 0.0 1.7 1 1 1 2 2 2 1 Methyltransferase small domain PCMT PF01135.19 CAV19816.1 - 8.3e-05 22.4 0.0 0.00015 21.6 0.0 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_11 PF08241.12 CAV19816.1 - 0.00012 22.7 0.0 0.00067 20.3 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain Methyltr_RsmB-F PF01189.17 CAV19816.1 - 0.00021 21.0 0.0 0.002 17.8 0.0 2.4 3 0 0 3 3 3 1 16S rRNA methyltransferase RsmB/F Methyltransf_23 PF13489.6 CAV19816.1 - 0.00026 20.9 0.0 0.001 18.9 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain RrnaAD PF00398.20 CAV19816.1 - 0.00062 18.9 0.0 0.001 18.2 0.0 1.3 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase DREV PF05219.12 CAV19816.1 - 0.005 16.0 0.0 0.0088 15.2 0.0 1.3 1 0 0 1 1 1 1 DREV methyltransferase Methyltransf_4 PF02390.17 CAV19816.1 - 0.043 13.3 0.0 0.081 12.4 0.0 1.4 1 0 0 1 1 1 0 Putative methyltransferase Methyltransf_15 PF09445.10 CAV19816.1 - 0.043 13.4 0.0 0.091 12.3 0.0 1.5 1 0 0 1 1 1 0 RNA cap guanine-N2 methyltransferase TPMT PF05724.11 CAV19816.1 - 0.061 13.0 0.1 0.14 11.8 0.1 1.5 1 0 0 1 1 1 0 Thiopurine S-methyltransferase (TPMT) Methyltransf_12 PF08242.12 CAV19816.1 - 0.062 14.0 0.0 0.18 12.6 0.0 1.8 1 0 0 1 1 1 0 Methyltransferase domain Sec-ASP3 PF15432.6 CAV19816.1 - 0.072 13.2 0.0 0.19 11.9 0.0 1.7 1 0 0 1 1 1 0 Accessory Sec secretory system ASP3 DUF2222 PF09984.9 CAV19820.1 - 5.4e-55 185.4 0.8 1.1e-54 184.4 0.8 1.5 1 0 0 1 1 1 1 Uncharacterised signal transduction histidine kinase domain (DUF2222) HATPase_c PF02518.26 CAV19820.1 - 1.5e-30 106.0 0.3 3.9e-30 104.7 0.3 1.8 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 CAV19820.1 - 2.3e-29 101.8 3.9 7.1e-28 97.0 1.0 3.2 3 0 0 3 3 3 1 Response regulator receiver domain HisKA PF00512.25 CAV19820.1 - 1.7e-21 76.0 1.4 4.6e-20 71.4 0.1 3.3 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain Hpt PF01627.23 CAV19820.1 - 3.1e-11 43.4 0.1 1.7e-10 41.0 0.0 2.4 3 0 0 3 3 3 1 Hpt domain HAMP PF00672.25 CAV19820.1 - 2.8e-06 27.6 0.1 7.2e-06 26.3 0.1 1.8 1 0 0 1 1 1 1 HAMP domain HATPase_c_3 PF13589.6 CAV19820.1 - 0.0014 18.4 0.0 0.0041 16.9 0.0 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Baculo_PEP_C PF04513.12 CAV19820.1 - 0.078 13.0 4.2 0.19 11.7 0.1 2.7 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus ACPS PF01648.20 CAV19821.1 - 1.1e-23 83.5 0.1 1.3e-23 83.3 0.1 1.0 1 0 0 1 1 1 1 4'-phosphopantetheinyl transferase superfamily SDA1 PF05285.12 CAV19821.1 - 0.028 13.9 0.1 0.029 13.8 0.1 1.1 1 0 0 1 1 1 0 SDA1 gp37_C PF12604.8 CAV19821.1 - 0.19 11.4 0.0 0.2 11.3 0.0 1.2 1 0 0 1 1 1 0 Tail fibre protein gp37 C terminal Tecti-min-caps PF09300.10 CAV19821.1 - 0.2 11.8 0.0 0.32 11.1 0.0 1.4 1 0 0 1 1 1 0 Tectiviridae, minor capsid PdxJ PF03740.13 CAV19823.1 - 6.8e-106 352.6 2.9 7.6e-106 352.5 2.9 1.0 1 0 0 1 1 1 1 Pyridoxal phosphate biosynthesis protein PdxJ AP_endonuc_2 PF01261.24 CAV19823.1 - 4.1e-05 23.1 2.1 0.00044 19.8 1.0 2.9 1 1 1 2 2 2 1 Xylose isomerase-like TIM barrel ALGX PF16822.5 CAV19823.1 - 0.12 12.0 0.0 0.19 11.4 0.0 1.3 1 0 0 1 1 1 0 SGNH hydrolase-like domain, acetyltransferase AlgX RecO_N PF11967.8 CAV19825.1 - 7.9e-24 83.4 0.0 1.5e-23 82.6 0.0 1.4 1 0 0 1 1 1 1 Recombination protein O N terminal RecO_C PF02565.15 CAV19825.1 - 1.2e-22 80.5 0.2 2.8e-22 79.2 0.2 1.6 1 1 0 1 1 1 1 Recombination protein O C terminal MMR_HSR1 PF01926.23 CAV19827.1 - 1e-23 83.6 0.2 2e-23 82.6 0.0 1.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase KH_2 PF07650.17 CAV19827.1 - 4e-21 74.6 0.4 6e-20 70.9 0.2 2.3 2 0 0 2 2 2 1 KH domain FeoB_N PF02421.18 CAV19827.1 - 8.8e-15 54.6 0.3 1.4e-14 53.9 0.3 1.2 1 0 0 1 1 1 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 CAV19827.1 - 1.5e-10 41.3 1.5 0.00027 20.9 0.1 2.2 1 1 1 2 2 2 2 RsgA GTPase GTP_EFTU PF00009.27 CAV19827.1 - 1.4e-09 37.7 1.8 2.2e-07 30.6 1.8 2.3 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Dynamin_N PF00350.23 CAV19827.1 - 3.2e-08 33.8 0.3 1.9e-05 24.8 0.1 2.4 1 1 1 2 2 2 2 Dynamin family AIG1 PF04548.16 CAV19827.1 - 7.8e-07 28.6 0.1 1.5e-06 27.7 0.1 1.5 1 0 0 1 1 1 1 AIG1 family PduV-EutP PF10662.9 CAV19827.1 - 8.7e-06 25.5 0.2 0.0002 21.1 0.2 2.5 1 1 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation Ras PF00071.22 CAV19827.1 - 9.9e-05 22.0 0.2 0.00044 19.9 0.1 2.0 2 1 0 2 2 2 1 Ras family MMR_HSR1_Xtn PF16897.5 CAV19827.1 - 0.00039 20.4 0.1 0.0009 19.2 0.1 1.6 1 0 0 1 1 1 1 C-terminal region of MMR_HSR1 domain AAA_22 PF13401.6 CAV19827.1 - 0.0004 20.7 0.0 0.0009 19.5 0.0 1.6 1 1 0 1 1 1 1 AAA domain cobW PF02492.19 CAV19827.1 - 0.0017 18.0 1.4 0.28 10.8 0.2 2.4 1 1 1 2 2 2 2 CobW/HypB/UreG, nucleotide-binding domain AAA_16 PF13191.6 CAV19827.1 - 0.0058 17.0 0.1 0.21 11.9 0.1 2.5 1 1 0 1 1 1 1 AAA ATPase domain NB-ARC PF00931.22 CAV19827.1 - 0.0097 15.1 0.0 0.069 12.3 0.0 2.0 2 0 0 2 2 2 1 NB-ARC domain ABC_tran PF00005.27 CAV19827.1 - 0.024 15.2 0.6 0.049 14.2 0.6 1.8 1 1 0 1 1 1 0 ABC transporter Roc PF08477.13 CAV19827.1 - 0.025 14.8 0.2 0.13 12.5 0.2 2.1 1 1 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase ATP_bind_1 PF03029.17 CAV19827.1 - 0.05 13.4 0.1 0.42 10.4 0.1 2.2 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein MeaB PF03308.16 CAV19827.1 - 0.058 12.4 0.3 7 5.6 0.1 2.2 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB DUF521 PF04412.13 CAV19827.1 - 0.082 11.6 0.0 0.12 11.0 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF521) Ribonucleas_3_3 PF14622.6 CAV19828.1 - 2.3e-33 115.1 0.0 3.2e-33 114.6 0.0 1.2 1 0 0 1 1 1 1 Ribonuclease-III-like Ribonuclease_3 PF00636.26 CAV19828.1 - 3.5e-22 79.0 0.0 6e-22 78.3 0.0 1.4 1 0 0 1 1 1 1 Ribonuclease III domain dsrm PF00035.26 CAV19828.1 - 4.1e-16 59.4 0.0 6e-16 58.9 0.0 1.2 1 0 0 1 1 1 1 Double-stranded RNA binding motif DND1_DSRM PF14709.7 CAV19828.1 - 6.5e-05 23.1 0.0 0.00011 22.3 0.0 1.4 1 0 0 1 1 1 1 double strand RNA binding domain from DEAD END PROTEIN 1 Peptidase_S24 PF00717.23 CAV19830.1 - 6.8e-21 74.0 0.0 1.3e-20 73.1 0.0 1.5 1 0 0 1 1 1 1 Peptidase S24-like Peptidase_S26 PF10502.9 CAV19830.1 - 2.3e-11 43.6 0.0 8e-08 32.2 0.0 2.5 1 1 1 2 2 2 2 Signal peptidase, peptidase S26 Saf_2TM PF18303.1 CAV19830.1 - 0.046 13.3 0.1 0.079 12.5 0.1 1.4 1 0 0 1 1 1 0 SAVED-fused 2TM effector domain DUF5326 PF17260.2 CAV19830.1 - 0.077 13.1 3.6 2.3 8.4 0.1 2.4 2 0 0 2 2 2 0 Family of unknown function (DUF5326) DUF1422 PF07226.11 CAV19830.1 - 0.11 12.5 0.3 0.19 11.8 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1422) GTP_EFTU PF00009.27 CAV19832.1 - 1.5e-53 181.2 0.1 2.5e-53 180.5 0.1 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain LepA_C PF06421.12 CAV19832.1 - 6.8e-49 164.5 3.3 1.1e-48 163.8 3.3 1.4 1 0 0 1 1 1 1 GTP-binding protein LepA C-terminus EFG_C PF00679.24 CAV19832.1 - 1.3e-20 73.2 0.0 3.6e-20 71.8 0.0 1.8 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 CAV19832.1 - 1.4e-10 41.4 0.8 3.4e-10 40.2 0.8 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 CAV19832.1 - 1.5e-05 25.1 0.0 5.7e-05 23.2 0.0 2.0 2 0 0 2 2 2 1 50S ribosome-binding GTPase Ras PF00071.22 CAV19832.1 - 2.7e-05 23.8 0.0 5.2e-05 22.9 0.0 1.4 1 0 0 1 1 1 1 Ras family EFG_II PF14492.6 CAV19832.1 - 0.00021 21.3 0.0 0.0012 18.9 0.0 2.2 1 1 0 1 1 1 1 Elongation Factor G, domain II RF3_C PF16658.5 CAV19832.1 - 0.01 15.7 0.0 0.019 14.8 0.0 1.4 1 0 0 1 1 1 0 Class II release factor RF3, C-terminal domain SRPRB PF09439.10 CAV19832.1 - 0.025 14.0 0.0 0.054 12.9 0.0 1.6 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit RseC_MucC PF04246.12 CAV19834.1 - 2.1e-31 108.6 0.8 2.5e-31 108.3 0.8 1.0 1 0 0 1 1 1 1 Positive regulator of sigma(E), RseC/MucC FeoB_associated PF12669.7 CAV19834.1 - 1.5 9.3 7.2 0.15 12.5 1.9 2.0 2 0 0 2 2 2 0 FeoB-associated Cys-rich membrane protein MucB_RseB PF03888.14 CAV19836.1 - 6.7e-61 204.9 0.1 8.8e-61 204.5 0.1 1.2 1 0 0 1 1 1 1 MucB/RseB N-terminal domain MucB_RseB_C PF17188.4 CAV19836.1 - 2.5e-29 101.3 0.2 2.5e-28 98.1 0.1 2.1 2 0 0 2 2 2 1 MucB/RseB C-terminal domain LolA_like PF17131.4 CAV19836.1 - 1.1e-05 25.3 0.1 1.8e-05 24.6 0.1 1.3 1 0 0 1 1 1 1 Outer membrane lipoprotein-sorting protein RseA_N PF03872.13 CAV19838.1 - 1.3e-34 118.5 0.8 1.3e-34 118.5 0.8 1.7 2 0 0 2 2 2 1 Anti sigma-E protein RseA, N-terminal domain RseA_C PF03873.13 CAV19838.1 - 7.3e-20 71.0 4.8 9.1e-19 67.4 0.7 2.3 2 0 0 2 2 2 2 Anti sigma-E protein RseA, C-terminal domain Sigma70_r4_2 PF08281.12 CAV19840.1 - 2.1e-18 65.7 0.3 5.4e-18 64.4 0.0 1.9 2 0 0 2 2 2 1 Sigma-70, region 4 Sigma70_r2 PF04542.14 CAV19840.1 - 2.9e-18 65.4 0.1 4.8e-18 64.7 0.1 1.4 1 0 0 1 1 1 1 Sigma-70 region 2 Sigma70_r4 PF04545.16 CAV19840.1 - 1e-10 41.0 0.3 2e-10 40.0 0.1 1.6 2 0 0 2 2 2 1 Sigma-70, region 4 Sigma70_ECF PF07638.11 CAV19840.1 - 5.5e-09 36.2 0.0 1.1e-08 35.2 0.0 1.5 1 1 0 1 1 1 1 ECF sigma factor HTH_23 PF13384.6 CAV19840.1 - 0.00033 20.3 0.0 0.0028 17.4 0.0 2.3 2 0 0 2 2 2 1 Homeodomain-like domain HTH_16 PF12645.7 CAV19840.1 - 0.011 15.8 0.0 0.026 14.6 0.0 1.7 1 1 0 1 1 1 0 Helix-turn-helix domain HTH_3 PF01381.22 CAV19840.1 - 0.11 12.5 0.0 0.32 11.1 0.0 1.8 2 0 0 2 2 2 0 Helix-turn-helix GerE PF00196.19 CAV19840.1 - 0.13 11.9 0.0 0.48 10.0 0.0 1.9 2 0 0 2 2 2 0 Bacterial regulatory proteins, luxR family HTH_20 PF12840.7 CAV19840.1 - 0.14 12.2 0.0 0.33 11.1 0.0 1.7 1 0 0 1 1 1 0 Helix-turn-helix domain FAD_binding_2 PF00890.24 CAV19844.1 - 1.3e-101 340.7 0.4 2e-101 340.1 0.4 1.2 1 0 0 1 1 1 1 FAD binding domain Succ_DH_flav_C PF02910.20 CAV19844.1 - 4e-15 55.9 0.5 1.1e-14 54.5 0.5 1.7 1 1 0 1 1 1 1 Fumarate reductase flavoprotein C-term DAO PF01266.24 CAV19844.1 - 9.5e-10 38.6 3.4 4.2e-08 33.2 3.4 2.2 1 1 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 CAV19844.1 - 1.6e-08 34.1 1.5 4.9e-05 22.7 0.6 2.7 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 CAV19844.1 - 1e-05 25.0 0.6 0.01 15.1 0.3 2.2 2 0 0 2 2 2 2 FAD binding domain HI0933_like PF03486.14 CAV19844.1 - 0.00045 19.0 0.4 0.11 11.1 0.2 3.0 3 0 0 3 3 3 1 HI0933-like protein Lycopene_cycl PF05834.12 CAV19844.1 - 0.0015 17.7 0.1 0.0039 16.3 0.1 1.7 2 0 0 2 2 2 1 Lycopene cyclase protein Thi4 PF01946.17 CAV19844.1 - 0.002 17.4 2.4 0.087 12.0 0.1 2.7 3 0 0 3 3 3 1 Thi4 family GIDA PF01134.22 CAV19844.1 - 0.0023 17.1 4.3 0.02 14.0 0.1 2.4 2 1 0 2 2 2 1 Glucose inhibited division protein A NAD_binding_8 PF13450.6 CAV19844.1 - 0.0026 18.0 0.3 0.066 13.4 0.5 2.7 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain GMC_oxred_N PF00732.19 CAV19844.1 - 0.026 13.9 0.2 2.2 7.6 0.0 2.3 2 0 0 2 2 2 0 GMC oxidoreductase NAD_binding_7 PF13241.6 CAV19844.1 - 0.048 14.1 0.1 0.16 12.4 0.1 1.9 1 0 0 1 1 1 0 Putative NAD(P)-binding Sdh5 PF03937.16 CAV19848.1 - 7.9e-24 83.4 0.0 9.1e-24 83.2 0.0 1.0 1 0 0 1 1 1 1 Flavinator of succinate dehydrogenase DUF5367 PF17329.2 CAV19848.1 - 0.084 13.0 0.0 0.12 12.5 0.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5367) GCV_T PF01571.21 CAV19849.1 - 2e-05 24.1 0.2 3e-05 23.5 0.2 1.2 1 0 0 1 1 1 1 Aminomethyltransferase folate-binding domain tRNA_edit PF04073.15 CAV19851.1 - 3.1e-29 101.5 0.0 3.6e-29 101.3 0.0 1.1 1 0 0 1 1 1 1 Aminoacyl-tRNA editing domain DUF1107 PF06526.12 CAV19852.1 - 1.8e-29 101.4 0.5 2e-29 101.3 0.5 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1107) FAD_binding_3 PF01494.19 CAV19854.1 - 2.9e-31 109.0 0.1 3.9e-31 108.6 0.1 1.2 1 0 0 1 1 1 1 FAD binding domain Trp_halogenase PF04820.14 CAV19854.1 - 1.3e-05 24.3 2.0 0.0013 17.7 0.1 2.1 2 0 0 2 2 2 2 Tryptophan halogenase DAO PF01266.24 CAV19854.1 - 0.00013 21.6 0.2 0.00024 20.8 0.2 1.5 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 CAV19854.1 - 0.00026 21.2 0.4 0.00061 20.0 0.4 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 CAV19854.1 - 0.00061 19.1 0.2 0.018 14.3 0.1 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 CAV19854.1 - 0.00072 18.7 7.3 0.11 11.5 4.4 3.1 2 1 0 2 2 2 1 Lycopene cyclase protein SE PF08491.10 CAV19854.1 - 0.0024 17.0 0.0 0.0073 15.4 0.0 1.8 2 0 0 2 2 2 1 Squalene epoxidase FAD_binding_2 PF00890.24 CAV19854.1 - 0.0025 17.0 0.3 0.0045 16.1 0.3 1.4 1 0 0 1 1 1 1 FAD binding domain Thi4 PF01946.17 CAV19854.1 - 0.0068 15.7 0.1 0.011 15.0 0.1 1.3 1 0 0 1 1 1 1 Thi4 family Pyr_redox PF00070.27 CAV19854.1 - 0.0074 16.8 0.6 0.025 15.1 0.2 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 CAV19854.1 - 0.012 14.9 0.0 0.02 14.1 0.0 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 CAV19854.1 - 0.079 12.9 0.5 1.4 8.9 0.1 2.4 2 0 0 2 2 2 0 FAD-NAD(P)-binding IlvN PF07991.12 CAV19854.1 - 0.093 12.3 0.1 0.18 11.4 0.1 1.5 1 0 0 1 1 1 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain XdhC_C PF13478.6 CAV19854.1 - 0.11 13.0 0.0 0.22 12.0 0.0 1.5 1 0 0 1 1 1 0 XdhC Rossmann domain HI0933_like PF03486.14 CAV19854.1 - 0.13 11.0 2.6 1.5 7.4 0.8 2.1 2 0 0 2 2 2 0 HI0933-like protein FAD_binding_3 PF01494.19 CAV19856.1 - 3.2e-25 89.1 0.1 4.2e-25 88.7 0.1 1.1 1 0 0 1 1 1 1 FAD binding domain Trp_halogenase PF04820.14 CAV19856.1 - 3.2e-05 23.0 0.5 0.11 11.3 0.1 2.2 2 0 0 2 2 2 2 Tryptophan halogenase Pyr_redox_2 PF07992.14 CAV19856.1 - 0.00071 18.9 0.4 0.34 10.1 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase SE PF08491.10 CAV19856.1 - 0.0084 15.2 0.0 0.015 14.4 0.0 1.3 1 0 0 1 1 1 1 Squalene epoxidase Lycopene_cycl PF05834.12 CAV19856.1 - 0.029 13.4 0.5 3.7 6.5 0.0 2.7 2 1 0 2 2 2 0 Lycopene cyclase protein DAO PF01266.24 CAV19856.1 - 0.15 11.6 0.8 1.5 8.3 0.5 2.0 1 1 0 2 2 2 0 FAD dependent oxidoreductase UPF0149 PF03695.13 CAV19858.1 - 2.6e-34 119.0 3.1 3.1e-34 118.8 3.1 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0149) ZapA PF05164.13 CAV19860.1 - 3.8e-19 68.9 1.5 4.4e-19 68.7 1.5 1.1 1 0 0 1 1 1 1 Cell division protein ZapA OPA3 PF07047.12 CAV19860.1 - 0.021 14.6 0.5 0.028 14.2 0.5 1.5 1 1 0 1 1 1 0 Optic atrophy 3 protein (OPA3) Matrilin_ccoil PF10393.9 CAV19860.1 - 0.071 13.0 5.2 0.36 10.7 0.4 2.9 1 1 2 3 3 3 0 Trimeric coiled-coil oligomerisation domain of matrilin Aida_N PF08910.10 CAV19860.1 - 0.13 12.7 1.8 0.15 12.4 1.8 1.3 1 1 0 1 1 1 0 Aida N-terminus 5-FTHF_cyc-lig PF01812.20 CAV19862.1 - 5.1e-45 153.6 0.0 5.8e-45 153.4 0.0 1.0 1 0 0 1 1 1 1 5-formyltetrahydrofolate cyclo-ligase family Rib_5-P_isom_A PF06026.14 CAV19864.1 - 5.5e-55 185.6 0.4 6.5e-55 185.4 0.4 1.1 1 0 0 1 1 1 1 Ribose 5-phosphate isomerase A (phosphoriboisomerase A) DeoRC PF00455.22 CAV19864.1 - 0.001 19.0 0.0 0.0023 17.9 0.0 1.6 1 1 0 1 1 1 1 DeoR C terminal sensor domain Sugar-bind PF04198.13 CAV19864.1 - 0.022 13.9 0.1 0.033 13.3 0.1 1.2 1 0 0 1 1 1 0 Putative sugar-binding domain 2-Hacid_dh_C PF02826.19 CAV19866.1 - 1e-52 178.1 0.0 2e-52 177.1 0.0 1.5 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 CAV19866.1 - 1.2e-38 131.8 0.0 1.9e-38 131.1 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.15 CAV19866.1 - 5e-07 30.0 0.1 1.9e-06 28.1 0.0 2.0 2 0 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase ACT PF01842.25 CAV19866.1 - 3.6e-05 23.5 0.1 0.00014 21.6 0.1 2.1 1 1 0 1 1 1 1 ACT domain AdoHcyase_NAD PF00670.21 CAV19866.1 - 0.0023 18.0 0.0 0.0042 17.2 0.0 1.3 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain DpaA_N PF16924.5 CAV19866.1 - 0.0033 17.5 0.0 0.069 13.2 0.0 2.7 3 0 0 3 3 3 1 Dipicolinate synthase subunit A N-terminal domain IlvN PF07991.12 CAV19866.1 - 0.0055 16.3 0.0 0.015 14.9 0.0 1.6 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain ACT_4 PF13291.6 CAV19866.1 - 0.017 15.7 0.0 0.04 14.5 0.0 1.6 1 0 0 1 1 1 0 ACT domain AlaDh_PNT_C PF01262.21 CAV19866.1 - 0.032 13.5 0.0 0.2 10.9 0.0 2.1 1 1 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Pyr_redox PF00070.27 CAV19866.1 - 0.077 13.6 0.1 2.9 8.5 0.0 2.7 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase 3HCDH_N PF02737.18 CAV19866.1 - 0.088 12.7 0.1 0.32 10.8 0.1 1.8 1 1 1 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain UDPG_MGDP_dh_N PF03721.14 CAV19866.1 - 0.14 11.7 0.1 0.4 10.2 0.1 1.8 2 0 0 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain SIMPL PF04402.14 CAV19867.1 - 1.3e-39 136.7 4.3 1.7e-39 136.4 4.3 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF541) HTH_1 PF00126.27 CAV19869.1 - 3.6e-18 65.3 0.1 1.7e-17 63.1 0.0 2.0 2 0 0 2 2 2 1 Bacterial regulatory helix-turn-helix protein, lysR family LysR_substrate PF03466.20 CAV19869.1 - 4.8e-15 55.5 0.0 8.5e-15 54.7 0.0 1.3 1 0 0 1 1 1 1 LysR substrate binding domain HTH_30 PF13556.6 CAV19869.1 - 0.0026 17.5 0.1 0.0069 16.2 0.0 1.8 2 0 0 2 2 2 1 PucR C-terminal helix-turn-helix domain HTH_24 PF13412.6 CAV19869.1 - 0.0039 16.7 0.0 0.0095 15.5 0.0 1.7 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding Mga PF05043.13 CAV19869.1 - 0.0042 17.6 0.0 0.013 16.1 0.0 1.8 1 0 0 1 1 1 1 Mga helix-turn-helix domain HTH_AsnC-type PF13404.6 CAV19869.1 - 0.01 15.7 0.0 0.03 14.1 0.0 1.9 1 0 0 1 1 1 0 AsnC-type helix-turn-helix domain HTH_11 PF08279.12 CAV19869.1 - 0.023 14.6 0.0 0.084 12.8 0.0 1.9 2 0 0 2 2 2 0 HTH domain Sigma70_r4 PF04545.16 CAV19869.1 - 0.027 14.0 0.1 0.084 12.4 0.1 1.8 1 0 0 1 1 1 0 Sigma-70, region 4 MarR_2 PF12802.7 CAV19869.1 - 0.036 14.0 0.0 0.11 12.4 0.0 1.8 2 0 0 2 2 2 0 MarR family HTH_50 PF18024.1 CAV19869.1 - 0.056 13.1 0.0 0.11 12.2 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_28 PF13518.6 CAV19869.1 - 0.1 12.7 1.5 0.3 11.3 0.6 2.3 2 0 0 2 2 2 0 Helix-turn-helix domain LysE PF01810.18 CAV19871.1 - 4.6e-40 137.1 7.0 6.1e-40 136.7 7.0 1.1 1 0 0 1 1 1 1 LysE type translocator IncD PF17628.2 CAV19871.1 - 2.3 8.0 6.7 1.2 8.9 0.1 2.5 2 2 0 2 2 2 0 Inclusion membrane protein D MS_channel PF00924.18 CAV19873.1 - 1.7e-57 194.3 0.3 1.7e-57 194.3 0.3 1.4 2 0 0 2 2 2 1 Mechanosensitive ion channel TM_helix PF05552.12 CAV19873.1 - 3.1e-13 49.5 0.7 3.1e-13 49.5 0.7 2.1 2 0 0 2 2 2 1 Conserved TM helix ABC2_membrane_5 PF13346.6 CAV19873.1 - 0.21 11.1 5.9 0.31 10.5 5.9 1.2 1 0 0 1 1 1 0 ABC-2 family transporter protein F_bP_aldolase PF01116.20 CAV19875.1 - 3.1e-85 286.1 0.0 3.7e-85 285.8 0.0 1.0 1 0 0 1 1 1 1 Fructose-bisphosphate aldolase class-II PGK PF00162.19 CAV19877.2 - 2.6e-137 457.8 1.4 3e-137 457.6 1.4 1.0 1 0 0 1 1 1 1 Phosphoglycerate kinase Gp_dh_C PF02800.20 CAV19880.1 - 2.3e-55 186.5 2.4 3.2e-55 186.1 2.4 1.2 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain Gp_dh_N PF00044.24 CAV19880.1 - 9.7e-31 106.1 0.7 1.1e-29 102.7 0.0 2.3 2 0 0 2 2 2 1 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain DapB_N PF01113.20 CAV19880.1 - 0.0056 16.8 0.2 0.032 14.3 0.0 2.2 2 0 0 2 2 2 1 Dihydrodipicolinate reductase, N-terminus Asp23 PF03780.13 CAV19880.1 - 0.014 15.8 0.2 0.036 14.5 0.2 1.7 1 0 0 1 1 1 0 Asp23 family, cell envelope-related function NAD_binding_3 PF03447.16 CAV19880.1 - 0.025 15.2 0.1 0.63 10.7 0.1 2.3 1 1 0 1 1 1 0 Homoserine dehydrogenase, NAD binding domain GFO_IDH_MocA PF01408.22 CAV19880.1 - 0.078 13.8 0.2 0.4 11.5 0.0 2.0 2 0 0 2 2 2 0 Oxidoreductase family, NAD-binding Rossmann fold PTS_EIIC PF02378.18 CAV19882.1 - 3.2e-77 259.7 35.3 5.9e-77 258.8 35.3 1.4 1 0 0 1 1 1 1 Phosphotransferase system, EIIC PTS_EIIB PF00367.20 CAV19882.1 - 2e-11 43.2 0.2 3.3e-11 42.5 0.2 1.4 1 0 0 1 1 1 1 phosphotransferase system, EIIB Tim17 PF02466.19 CAV19882.1 - 0.69 10.3 11.9 3.8 7.9 8.7 3.6 1 1 1 2 2 2 0 Tim17/Tim22/Tim23/Pmp24 family SBP_bac_8 PF13416.6 CAV19884.1 - 4.1e-16 59.6 0.1 5.8e-16 59.1 0.1 1.1 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_1 PF01547.25 CAV19884.1 - 4.7e-16 59.6 0.9 6.4e-16 59.2 0.9 1.2 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein HATPase_c PF02518.26 CAV19885.1 - 1.5e-18 67.4 0.3 4.2e-18 65.9 0.0 1.9 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 CAV19885.1 - 7.6e-05 22.7 0.0 0.0002 21.3 0.0 1.8 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain HATPase_c_3 PF13589.6 CAV19885.1 - 0.0024 17.7 0.2 0.017 14.9 0.1 2.2 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Sec3_C_2 PF15278.6 CAV19885.1 - 0.036 14.4 0.1 0.13 12.6 0.1 2.0 1 0 0 1 1 1 0 Sec3 exocyst complex subunit Response_reg PF00072.24 CAV19887.1 - 2e-29 102.0 0.4 3.9e-29 101.1 0.4 1.5 1 0 0 1 1 1 1 Response regulator receiver domain Trans_reg_C PF00486.28 CAV19887.1 - 3.8e-19 68.5 0.1 9.3e-19 67.3 0.1 1.6 1 0 0 1 1 1 1 Transcriptional regulatory protein, C terminal Arg_decarbox_C PF17944.1 CAV19887.1 - 0.0043 17.6 0.2 1.2 9.8 0.0 2.9 3 0 0 3 3 3 2 Arginine decarboxylase C-terminal helical extension zf_UBZ PF18439.1 CAV19889.1 - 0.26 10.9 2.0 0.34 10.6 0.1 1.9 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger Transketolase_N PF00456.21 CAV19891.1 - 4e-165 548.7 0.2 6.5e-165 548.0 0.2 1.3 1 0 0 1 1 1 1 Transketolase, thiamine diphosphate binding domain Transket_pyr PF02779.24 CAV19891.1 - 2.8e-48 164.0 0.2 6.4e-48 162.8 0.2 1.7 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.20 CAV19891.1 - 6.2e-20 71.3 0.0 1.2e-19 70.4 0.0 1.5 1 0 0 1 1 1 1 Transketolase, C-terminal domain DXP_synthase_N PF13292.6 CAV19891.1 - 2e-06 27.2 0.0 0.0065 15.7 0.1 2.5 1 1 1 2 2 2 2 1-deoxy-D-xylulose-5-phosphate synthase E1_dh PF00676.20 CAV19891.1 - 0.00019 20.5 0.0 0.00034 19.7 0.0 1.4 1 0 0 1 1 1 1 Dehydrogenase E1 component TPP_enzyme_C PF02775.21 CAV19891.1 - 0.0014 18.5 0.8 0.049 13.4 0.8 2.7 1 1 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain S-AdoMet_synt_C PF02773.16 CAV19893.1 - 2e-69 231.9 0.0 3.3e-69 231.2 0.0 1.4 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, C-terminal domain S-AdoMet_synt_M PF02772.16 CAV19893.1 - 1.6e-44 151.0 0.0 7.4e-44 148.8 0.0 2.0 2 0 0 2 2 2 1 S-adenosylmethionine synthetase, central domain S-AdoMet_synt_N PF00438.20 CAV19893.1 - 2.4e-43 146.9 0.3 5e-43 145.8 0.3 1.6 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, N-terminal domain AdoMet_Synthase PF01941.19 CAV19893.1 - 0.033 13.0 0.9 1 8.1 0.2 2.5 2 1 1 3 3 3 0 S-adenosylmethionine synthetase (AdoMet synthetase) Lactamase_B_2 PF12706.7 CAV19893.1 - 0.06 12.8 0.0 0.11 12.0 0.0 1.4 1 0 0 1 1 1 0 Beta-lactamase superfamily domain ABC_tran PF00005.27 CAV19895.1 - 3.8e-31 108.4 0.1 6e-31 107.8 0.1 1.3 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 CAV19895.1 - 4.8e-11 43.0 1.1 3.8e-05 23.7 0.3 2.2 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 CAV19895.1 - 3.9e-08 33.0 0.1 1e-07 31.6 0.1 1.6 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 CAV19895.1 - 4.7e-05 23.1 0.0 8.5e-05 22.2 0.0 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_15 PF13175.6 CAV19895.1 - 7.4e-05 22.6 0.0 0.00017 21.5 0.0 1.8 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 CAV19895.1 - 0.00012 22.4 0.1 0.00023 21.4 0.1 1.4 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.6 CAV19895.1 - 0.00027 21.1 0.0 0.0011 19.1 0.0 1.9 1 1 0 1 1 1 1 AAA domain ATPase_2 PF01637.18 CAV19895.1 - 0.00043 20.3 0.0 0.00072 19.5 0.0 1.4 1 0 0 1 1 1 1 ATPase domain predominantly from Archaea SbcCD_C PF13558.6 CAV19895.1 - 0.00056 20.1 0.1 0.022 15.0 0.1 2.3 1 1 0 1 1 1 1 Putative exonuclease SbcCD, C subunit AAA_5 PF07728.14 CAV19895.1 - 0.00081 19.4 0.1 0.57 10.2 0.0 2.4 2 1 0 2 2 2 2 AAA domain (dynein-related subfamily) NACHT PF05729.12 CAV19895.1 - 0.0036 17.2 0.3 0.0062 16.5 0.3 1.6 1 1 0 1 1 1 1 NACHT domain AAA_19 PF13245.6 CAV19895.1 - 0.0047 17.3 0.3 0.028 14.7 0.1 2.2 2 1 0 2 2 1 1 AAA domain AAA_7 PF12775.7 CAV19895.1 - 0.0055 16.2 0.1 0.014 14.9 0.0 1.7 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_30 PF13604.6 CAV19895.1 - 0.0071 16.1 0.0 0.014 15.1 0.0 1.7 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 CAV19895.1 - 0.0073 16.7 0.2 0.011 16.2 0.2 1.4 1 1 0 1 1 1 1 AAA ATPase domain AAA_23 PF13476.6 CAV19895.1 - 0.013 16.0 2.6 0.027 15.0 2.4 1.9 1 1 0 1 1 1 0 AAA domain T2SSE PF00437.20 CAV19895.1 - 0.015 14.4 0.0 0.025 13.6 0.0 1.5 1 0 0 1 1 1 0 Type II/IV secretion system protein MobB PF03205.14 CAV19895.1 - 0.018 14.9 0.1 0.046 13.6 0.1 1.6 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_28 PF13521.6 CAV19895.1 - 0.023 14.9 0.0 0.031 14.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain FtsK_SpoIIIE PF01580.18 CAV19895.1 - 0.026 13.9 0.0 0.044 13.1 0.0 1.3 1 0 0 1 1 1 0 FtsK/SpoIIIE family RsgA_GTPase PF03193.16 CAV19895.1 - 0.026 14.4 0.0 0.052 13.4 0.0 1.5 1 0 0 1 1 1 0 RsgA GTPase PIF1 PF05970.14 CAV19895.1 - 0.037 13.2 0.0 0.08 12.1 0.0 1.5 2 0 0 2 2 2 0 PIF1-like helicase ABC_ATPase PF09818.9 CAV19895.1 - 0.039 12.8 0.0 0.78 8.5 0.0 2.3 2 1 0 2 2 2 0 Predicted ATPase of the ABC class AAA_18 PF13238.6 CAV19895.1 - 0.043 14.4 0.0 0.068 13.7 0.0 1.6 1 1 0 1 1 1 0 AAA domain AAA PF00004.29 CAV19895.1 - 0.051 14.0 0.4 0.12 12.8 0.0 2.0 2 2 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Thymidylate_kin PF02223.17 CAV19895.1 - 0.058 13.1 0.2 0.54 9.9 0.0 2.1 2 0 0 2 2 2 0 Thymidylate kinase AAA_27 PF13514.6 CAV19895.1 - 0.058 13.0 0.0 0.13 11.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain MMR_HSR1 PF01926.23 CAV19895.1 - 0.075 13.1 0.0 0.15 12.1 0.0 1.6 1 0 0 1 1 1 0 50S ribosome-binding GTPase PduV-EutP PF10662.9 CAV19895.1 - 0.077 12.7 0.1 0.22 11.3 0.0 1.7 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Pox_A32 PF04665.12 CAV19895.1 - 0.086 12.3 0.0 0.15 11.5 0.0 1.3 1 0 0 1 1 1 0 Poxvirus A32 protein ATP_bind_1 PF03029.17 CAV19895.1 - 0.088 12.6 0.0 0.17 11.6 0.0 1.5 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein cobW PF02492.19 CAV19895.1 - 0.091 12.3 0.0 0.2 11.2 0.0 1.5 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain Peripla_BP_2 PF01497.18 CAV19896.1 - 1.6e-23 83.5 0.0 2.3e-23 83.0 0.0 1.1 1 0 0 1 1 1 1 Periplasmic binding protein FecCD PF01032.18 CAV19898.1 - 8.9e-89 297.6 38.1 1.1e-88 297.3 38.1 1.0 1 0 0 1 1 1 1 FecCD transport family ABC-3 PF00950.17 CAV19898.1 - 0.16 11.5 30.7 0.044 13.3 26.0 2.2 1 1 1 2 2 2 0 ABC 3 transport family MpPF26 PF07666.11 CAV19898.1 - 5.5 7.1 13.8 4 7.5 2.0 3.5 3 0 0 3 3 3 0 M penetrans paralogue family 26 His_Phos_1 PF00300.22 CAV19900.1 - 1.5e-24 86.8 0.1 8.9e-21 74.5 0.0 2.0 1 1 1 2 2 2 2 Histidine phosphatase superfamily (branch 1) MBD PF01429.19 CAV19900.1 - 0.12 12.1 0.0 0.22 11.3 0.0 1.5 1 1 0 1 1 1 0 Methyl-CpG binding domain CbiD PF01888.17 CAV19902.1 - 5.5e-80 268.3 1.0 7.4e-80 267.9 1.0 1.2 1 0 0 1 1 1 1 CbiD DUF4232 PF14016.6 CAV19902.1 - 0.21 11.7 1.3 0.61 10.2 0.1 2.3 3 0 0 3 3 3 0 Protein of unknown function (DUF4232) CbiC PF02570.15 CAV19904.1 - 2.1e-74 249.5 0.1 2.3e-74 249.3 0.1 1.0 1 0 0 1 1 1 1 Precorrin-8X methylmutase TP_methylase PF00590.20 CAV19906.1 - 6.1e-26 91.7 0.0 8.2e-26 91.3 0.0 1.2 1 0 0 1 1 1 1 Tetrapyrrole (Corrin/Porphyrin) Methylases Methyltransf_4 PF02390.17 CAV19906.1 - 1.3e-05 24.8 0.0 4.7e-05 22.9 0.0 1.9 2 0 0 2 2 2 1 Putative methyltransferase Methyltransf_25 PF13649.6 CAV19906.1 - 2.2e-05 25.1 0.0 4.7e-05 24.0 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CAV19906.1 - 5.2e-05 23.1 0.0 9.4e-05 22.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain GCD14 PF08704.10 CAV19906.1 - 7.5e-05 22.5 0.0 0.00012 21.8 0.0 1.2 1 0 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit Methyltransf_18 PF12847.7 CAV19906.1 - 8.9e-05 22.5 0.0 0.00026 21.0 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain PCMT PF01135.19 CAV19906.1 - 0.00011 22.1 0.0 0.00018 21.3 0.0 1.4 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) MTS PF05175.14 CAV19906.1 - 0.00025 20.6 0.0 0.00044 19.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Cons_hypoth95 PF03602.15 CAV19906.1 - 0.00045 19.9 0.0 0.00073 19.2 0.0 1.2 1 0 0 1 1 1 1 Conserved hypothetical protein 95 CMAS PF02353.20 CAV19906.1 - 0.0011 18.4 0.0 0.0046 16.3 0.0 1.9 2 0 0 2 2 2 1 Mycolic acid cyclopropane synthetase Methyltransf_24 PF13578.6 CAV19906.1 - 0.0028 18.7 0.0 0.0074 17.3 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain DUF938 PF06080.12 CAV19906.1 - 0.0075 16.1 0.0 0.013 15.3 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF938) RrnaAD PF00398.20 CAV19906.1 - 0.015 14.4 0.0 0.022 13.8 0.0 1.1 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase PrmA PF06325.13 CAV19906.1 - 0.034 13.5 0.0 0.056 12.8 0.0 1.3 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Met_10 PF02475.16 CAV19906.1 - 0.036 13.8 0.0 0.058 13.1 0.0 1.3 1 0 0 1 1 1 0 Met-10+ like-protein Methyltransf_23 PF13489.6 CAV19906.1 - 0.093 12.6 0.0 0.31 10.9 0.0 1.8 1 1 0 1 1 1 0 Methyltransferase domain TP_methylase PF00590.20 CAV19907.1 - 2e-46 158.7 0.0 2.3e-46 158.4 0.0 1.1 1 0 0 1 1 1 1 Tetrapyrrole (Corrin/Porphyrin) Methylases Aldolase PF01081.19 CAV19907.1 - 0.12 11.8 0.0 0.18 11.2 0.0 1.2 1 0 0 1 1 1 0 KDPG and KHG aldolase CbiG_N PF11760.8 CAV19909.1 - 5e-32 109.7 0.0 1.4e-31 108.3 0.0 1.7 1 0 0 1 1 1 1 Cobalamin synthesis G N-terminal CbiG_C PF01890.16 CAV19909.1 - 5.4e-31 107.5 0.0 1e-30 106.7 0.0 1.4 1 0 0 1 1 1 1 Cobalamin synthesis G C-terminus CbiG_mid PF11761.8 CAV19909.1 - 3.1e-11 43.2 0.1 1.9e-10 40.7 0.1 2.1 2 0 0 2 2 2 1 Cobalamin biosynthesis central region 2Fe-2S_thioredx PF01257.19 CAV19909.1 - 2e-05 24.5 0.0 3.6e-05 23.6 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin-like [2Fe-2S] ferredoxin CbiK PF06180.11 CAV19910.1 - 5.8e-19 68.4 0.0 7.5e-19 68.1 0.0 1.2 1 0 0 1 1 1 1 Cobalt chelatase (CbiK) CbiX PF01903.17 CAV19910.1 - 2.6e-05 24.5 0.1 0.14 12.4 0.0 3.3 2 1 0 2 2 2 2 CbiX DinI PF06183.13 CAV19910.1 - 0.0027 18.0 0.5 0.17 12.2 0.1 2.6 2 0 0 2 2 2 1 DinI-like family TP_methylase PF00590.20 CAV19912.1 - 3.8e-40 138.1 1.9 5.1e-40 137.7 1.9 1.2 1 0 0 1 1 1 1 Tetrapyrrole (Corrin/Porphyrin) Methylases DAGK_cat PF00781.24 CAV19912.1 - 0.008 15.8 0.1 0.061 12.9 0.0 2.0 2 0 0 2 2 2 1 Diacylglycerol kinase catalytic domain TP_methylase PF00590.20 CAV19914.1 - 3.2e-43 148.1 0.2 4e-43 147.8 0.2 1.1 1 0 0 1 1 1 1 Tetrapyrrole (Corrin/Porphyrin) Methylases CobD_Cbib PF03186.13 CAV19916.1 - 2.1e-87 292.9 0.0 2.5e-87 292.6 0.0 1.1 1 0 0 1 1 1 1 CobD/Cbib protein AmpE PF17113.5 CAV19916.1 - 0.0004 19.8 1.6 0.0004 19.8 1.6 1.9 2 0 0 2 2 2 1 Regulatory signalling modulator protein AmpE DUF4258 PF14076.6 CAV19916.1 - 0.012 16.0 0.0 0.021 15.2 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4258) Aminotran_1_2 PF00155.21 CAV19917.1 - 2.7e-20 72.9 0.0 3.6e-20 72.5 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II GATase_3 PF07685.14 CAV19919.1 - 7.7e-33 113.8 0.0 1.2e-32 113.1 0.0 1.2 1 0 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain CbiA PF01656.23 CAV19919.1 - 9.9e-16 58.0 0.0 1.9e-15 57.1 0.0 1.5 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_26 PF13500.6 CAV19919.1 - 1.1e-14 54.7 0.1 6.4e-08 32.7 0.0 2.4 2 0 0 2 2 2 2 AAA domain SNO PF01174.19 CAV19919.1 - 1.8e-05 24.7 0.0 3.2e-05 23.9 0.0 1.3 1 0 0 1 1 1 1 SNO glutamine amidotransferase family SRP54 PF00448.22 CAV19919.1 - 0.0077 15.9 0.2 0.018 14.7 0.2 1.5 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain MobB PF03205.14 CAV19919.1 - 0.0077 16.1 0.0 0.069 13.1 0.0 2.2 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B AAA_31 PF13614.6 CAV19919.1 - 0.0089 16.0 0.0 0.017 15.0 0.0 1.4 1 0 0 1 1 1 1 AAA domain PRK PF00485.18 CAV19919.1 - 0.014 15.2 0.4 1.3 8.7 0.2 2.3 1 1 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family MeaB PF03308.16 CAV19919.1 - 0.022 13.8 0.1 0.048 12.6 0.1 1.5 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB CoA_trans PF01144.23 CAV19919.1 - 0.026 13.9 0.0 0.04 13.3 0.0 1.3 1 0 0 1 1 1 0 Coenzyme A transferase AAA_30 PF13604.6 CAV19919.1 - 0.028 14.2 0.2 0.055 13.2 0.2 1.4 1 0 0 1 1 1 0 AAA domain APS_kinase PF01583.20 CAV19919.1 - 0.029 14.3 0.2 0.17 11.8 0.1 2.2 3 0 0 3 3 3 0 Adenylylsulphate kinase AAA_16 PF13191.6 CAV19919.1 - 0.03 14.7 0.0 0.068 13.6 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain DUF1611 PF07755.11 CAV19919.1 - 0.035 13.4 1.0 0.15 11.3 0.2 2.4 2 1 1 3 3 3 0 Domain of unknown function (DUF1611_C) P-loop domain LpxK PF02606.14 CAV19919.1 - 0.037 13.1 0.2 0.058 12.5 0.2 1.2 1 0 0 1 1 1 0 Tetraacyldisaccharide-1-P 4'-kinase CBP_BcsQ PF06564.12 CAV19919.1 - 0.05 13.1 0.0 0.087 12.3 0.0 1.3 1 0 0 1 1 1 0 Cellulose biosynthesis protein BcsQ ArsA_ATPase PF02374.15 CAV19919.1 - 0.1 11.8 0.2 0.25 10.5 0.2 1.5 1 0 0 1 1 1 0 Anion-transporting ATPase CTP_synth_N PF06418.14 CAV19919.1 - 0.11 11.7 0.0 0.19 11.0 0.0 1.3 1 0 0 1 1 1 0 CTP synthase N-terminus Thymidylate_kin PF02223.17 CAV19919.1 - 0.13 12.0 0.0 0.25 11.0 0.0 1.5 1 0 0 1 1 1 0 Thymidylate kinase DJ-1_PfpI PF01965.24 CAV19919.1 - 0.15 11.8 0.0 0.27 11.0 0.0 1.4 1 0 0 1 1 1 0 DJ-1/PfpI family KTI12 PF08433.10 CAV19919.1 - 0.15 11.4 0.1 0.27 10.6 0.1 1.3 1 0 0 1 1 1 0 Chromatin associated protein KTI12 DUF2189 PF09955.9 CAV19921.1 - 4.7e-26 91.5 12.5 4.7e-26 91.5 12.5 3.1 3 1 0 3 3 3 1 Predicted integral membrane protein (DUF2189) SprT-like PF10263.9 CAV19923.1 - 2e-17 63.1 0.1 2.9e-17 62.6 0.1 1.3 1 0 0 1 1 1 1 SprT-like family Zn_ribbon_SprT PF17283.2 CAV19923.1 - 3.6e-12 46.0 5.4 6.1e-12 45.2 5.4 1.4 1 0 0 1 1 1 1 SprT-like zinc ribbon domain SIR2 PF02146.17 CAV19923.1 - 0.02 14.8 0.4 0.026 14.5 0.4 1.1 1 0 0 1 1 1 0 Sir2 family A2L_zn_ribbon PF08792.10 CAV19923.1 - 0.021 14.6 0.1 0.046 13.4 0.1 1.6 1 0 0 1 1 1 0 A2L zinc ribbon domain Tnp_zf-ribbon_2 PF13842.6 CAV19923.1 - 0.67 10.8 6.7 1.5 9.7 6.7 1.6 1 1 0 1 1 1 0 DDE_Tnp_1-like zinc-ribbon Endonuclease_1 PF04231.13 CAV19925.1 - 1.5e-48 165.6 5.8 2.6e-48 164.7 5.8 1.4 1 1 0 1 1 1 1 Endonuclease I DUF1031 PF06275.11 CAV19925.1 - 0.0041 17.3 0.0 4.2 7.7 0.0 2.3 2 0 0 2 2 2 2 Protein of unknown function (DUF1031) DUF1524 PF07510.11 CAV19925.1 - 0.058 13.3 0.1 0.08 12.8 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1524) Big_9 PF17963.1 CAV19927.1 - 9.1e-09 35.9 0.4 9.1e-09 35.9 0.4 2.5 2 0 0 2 2 2 1 Bacterial Ig domain Cadherin_5 PF17892.1 CAV19927.1 - 3.8e-07 30.0 0.4 3.8e-07 30.0 0.4 1.9 2 0 0 2 2 2 1 Cadherin-like domain LPAM_1 PF08139.12 CAV19927.1 - 1.1 9.8 8.0 2.1 9.0 8.0 1.4 1 0 0 1 1 1 0 Prokaryotic membrane lipoprotein lipid attachment site Methyltrans_RNA PF04452.14 CAV19930.1 - 2.8e-73 246.0 0.1 3.2e-73 245.8 0.1 1.0 1 0 0 1 1 1 1 RNA methyltransferase ProQ_C PF17516.2 CAV19930.1 - 0.042 13.3 0.0 0.086 12.3 0.0 1.5 1 0 0 1 1 1 0 ProQ C-terminal domain CDC48_2 PF02933.17 CAV19930.1 - 0.15 11.8 0.2 9.7 6.1 0.0 2.3 2 0 0 2 2 2 0 Cell division protein 48 (CDC48), domain 2 GSH-S_ATP PF02955.16 CAV19932.1 - 4.8e-80 267.1 0.0 6.6e-80 266.6 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic glutathione synthetase, ATP-grasp domain GSH-S_N PF02951.14 CAV19932.1 - 4.4e-48 162.3 0.0 7.4e-48 161.6 0.0 1.4 1 0 0 1 1 1 1 Prokaryotic glutathione synthetase, N-terminal domain RimK PF08443.11 CAV19932.1 - 1.4e-11 44.3 0.0 2e-11 43.9 0.0 1.1 1 0 0 1 1 1 1 RimK-like ATP-grasp domain ATPgrasp_YheCD PF14398.6 CAV19932.1 - 1e-06 28.2 0.0 1.9e-06 27.3 0.0 1.4 1 0 0 1 1 1 1 YheC/D like ATP-grasp ATP-grasp_3 PF02655.14 CAV19932.1 - 0.0077 16.3 0.0 0.011 15.7 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp domain Cupredoxin_1 PF13473.6 CAV19932.1 - 0.044 13.9 0.0 0.086 13.0 0.0 1.4 1 0 0 1 1 1 0 Cupredoxin-like domain ATPgrasp_ST PF14397.6 CAV19932.1 - 0.069 12.4 0.0 0.33 10.1 0.0 1.9 1 1 1 2 2 2 0 Sugar-transfer associated ATP-grasp DUF179 PF02622.15 CAV19934.1 - 6.3e-50 169.3 0.0 7.2e-50 169.1 0.0 1.0 1 0 0 1 1 1 1 Uncharacterized ACR, COG1678 RuvX PF03652.15 CAV19936.1 - 4.7e-36 124.1 0.0 5.3e-36 124.0 0.0 1.0 1 0 0 1 1 1 1 Holliday junction resolvase GFO_IDH_MocA PF01408.22 CAV19936.1 - 0.1 13.4 0.0 0.19 12.6 0.0 1.4 1 1 0 1 1 1 0 Oxidoreductase family, NAD-binding Rossmann fold T2SSE PF00437.20 CAV19938.1 - 6.8e-39 133.6 0.4 1e-38 133.0 0.4 1.2 1 0 0 1 1 1 1 Type II/IV secretion system protein ABC_tran PF00005.27 CAV19938.1 - 8.4e-05 23.1 0.0 0.00018 22.0 0.0 1.6 1 1 0 1 1 1 1 ABC transporter AAA_29 PF13555.6 CAV19938.1 - 0.0006 19.5 0.1 0.0016 18.1 0.1 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_7 PF12775.7 CAV19938.1 - 0.0013 18.3 1.1 0.031 13.8 0.0 2.5 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_23 PF13476.6 CAV19938.1 - 0.0035 17.9 0.0 0.0083 16.7 0.0 1.8 1 1 0 1 1 1 1 AAA domain FtsK_SpoIIIE PF01580.18 CAV19938.1 - 0.0041 16.5 0.0 0.008 15.6 0.0 1.4 1 0 0 1 1 1 1 FtsK/SpoIIIE family AAA_27 PF13514.6 CAV19938.1 - 0.009 15.6 0.0 0.094 12.3 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 CAV19938.1 - 0.013 15.8 0.0 0.042 14.1 0.0 1.8 1 0 0 1 1 1 0 AAA domain ResIII PF04851.15 CAV19938.1 - 0.014 15.4 0.0 0.025 14.6 0.0 1.4 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit Ploopntkinase3 PF18751.1 CAV19938.1 - 0.017 15.0 0.1 0.036 14.0 0.1 1.6 1 1 0 1 1 1 0 P-loop Nucleotide Kinase3 AAA_16 PF13191.6 CAV19938.1 - 0.022 15.2 0.2 0.069 13.5 0.2 2.0 1 1 0 1 1 1 0 AAA ATPase domain AAA_30 PF13604.6 CAV19938.1 - 0.029 14.1 0.0 0.053 13.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain ATPase PF06745.13 CAV19938.1 - 0.076 12.4 0.0 0.14 11.5 0.0 1.5 1 0 0 1 1 1 0 KaiC SRP54 PF00448.22 CAV19938.1 - 0.082 12.5 0.8 0.23 11.1 0.1 2.1 3 0 0 3 3 3 0 SRP54-type protein, GTPase domain MMR_HSR1 PF01926.23 CAV19938.1 - 0.1 12.7 0.3 0.26 11.4 0.3 1.9 1 1 0 1 1 1 0 50S ribosome-binding GTPase AAA_33 PF13671.6 CAV19938.1 - 0.11 12.7 0.1 0.34 11.1 0.0 2.0 2 0 0 2 2 2 0 AAA domain DAP3 PF10236.9 CAV19938.1 - 0.11 11.6 0.0 0.23 10.6 0.0 1.5 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 ATP_bind_1 PF03029.17 CAV19938.1 - 0.12 12.2 0.1 0.26 11.0 0.1 1.6 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein DUF87 PF01935.17 CAV19938.1 - 0.19 11.8 3.0 0.73 9.9 2.9 2.2 1 1 0 1 1 1 0 Helicase HerA, central domain ATP-synt_ab PF00006.25 CAV19938.1 - 0.21 11.2 0.3 0.53 9.9 0.3 1.5 1 1 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain AAA_28 PF13521.6 CAV19938.1 - 0.59 10.4 2.5 1.2 9.4 0.6 2.3 2 1 0 2 2 2 0 AAA domain T2SSE PF00437.20 CAV19940.1 - 4.2e-46 157.2 0.4 7e-46 156.5 0.1 1.4 2 0 0 2 2 2 1 Type II/IV secretion system protein AAA_16 PF13191.6 CAV19940.1 - 1.6e-05 25.3 0.0 2.7e-05 24.6 0.0 1.4 1 1 0 1 1 1 1 AAA ATPase domain AAA_30 PF13604.6 CAV19940.1 - 0.00015 21.5 0.1 0.00088 19.0 0.1 2.3 1 1 0 1 1 1 1 AAA domain AAA_29 PF13555.6 CAV19940.1 - 0.00024 20.8 0.0 0.00057 19.6 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_23 PF13476.6 CAV19940.1 - 0.00025 21.6 0.0 0.0006 20.4 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 CAV19940.1 - 0.00043 20.6 0.0 0.0011 19.2 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 CAV19940.1 - 0.0012 19.2 1.3 0.0047 17.3 1.3 2.1 1 1 0 1 1 1 1 AAA domain ResIII PF04851.15 CAV19940.1 - 0.0013 18.8 0.0 0.0021 18.1 0.0 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DAP3 PF10236.9 CAV19940.1 - 0.0016 17.7 0.0 0.0026 17.0 0.0 1.3 1 0 0 1 1 1 1 Mitochondrial ribosomal death-associated protein 3 SRP54 PF00448.22 CAV19940.1 - 0.0016 18.1 0.0 0.0038 16.9 0.0 1.7 1 1 0 1 1 1 1 SRP54-type protein, GTPase domain FtsK_SpoIIIE PF01580.18 CAV19940.1 - 0.0046 16.3 0.0 0.021 14.2 0.0 2.0 2 0 0 2 2 2 1 FtsK/SpoIIIE family ABC_tran PF00005.27 CAV19940.1 - 0.0057 17.2 0.0 0.0098 16.4 0.0 1.4 1 0 0 1 1 1 1 ABC transporter TrwB_AAD_bind PF10412.9 CAV19940.1 - 0.0077 15.2 0.0 0.016 14.2 0.0 1.4 1 0 0 1 1 1 1 Type IV secretion-system coupling protein DNA-binding domain TK PF00265.18 CAV19940.1 - 0.0078 16.1 0.0 0.017 15.0 0.0 1.5 1 0 0 1 1 1 1 Thymidine kinase cobW PF02492.19 CAV19940.1 - 0.0082 15.8 0.1 0.072 12.7 0.0 2.1 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain Zeta_toxin PF06414.12 CAV19940.1 - 0.0085 15.4 0.0 0.017 14.4 0.0 1.5 1 0 0 1 1 1 1 Zeta toxin DUF87 PF01935.17 CAV19940.1 - 0.0099 16.0 0.1 0.014 15.5 0.1 1.5 1 1 0 1 1 1 1 Helicase HerA, central domain AAA_18 PF13238.6 CAV19940.1 - 0.011 16.3 0.0 0.023 15.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_27 PF13514.6 CAV19940.1 - 0.011 15.3 0.0 0.026 14.1 0.0 1.6 1 0 0 1 1 1 0 AAA domain Rad17 PF03215.15 CAV19940.1 - 0.012 15.6 0.0 0.04 13.9 0.0 1.8 1 1 1 2 2 2 0 Rad17 P-loop domain AAA_25 PF13481.6 CAV19940.1 - 0.013 15.1 0.0 0.023 14.3 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 CAV19940.1 - 0.013 15.0 0.0 0.034 13.6 0.0 1.7 1 0 0 1 1 1 0 P-loop containing dynein motor region NTPase_1 PF03266.15 CAV19940.1 - 0.021 14.8 0.6 0.44 10.4 0.1 2.6 2 1 1 3 3 2 0 NTPase PhoH PF02562.16 CAV19940.1 - 0.024 14.1 0.0 0.064 12.7 0.0 1.8 2 0 0 2 2 1 0 PhoH-like protein AAA PF00004.29 CAV19940.1 - 0.024 15.0 0.0 0.053 13.9 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) PRK PF00485.18 CAV19940.1 - 0.025 14.3 0.0 0.16 11.7 0.0 2.0 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family SMC_N PF02463.19 CAV19940.1 - 0.038 13.4 0.0 0.072 12.5 0.0 1.4 1 0 0 1 1 1 0 RecF/RecN/SMC N terminal domain AAA_11 PF13086.6 CAV19940.1 - 0.039 13.8 0.8 0.14 12.0 0.8 2.1 1 1 0 1 1 1 0 AAA domain ATP_bind_1 PF03029.17 CAV19940.1 - 0.044 13.6 0.6 0.091 12.5 0.1 1.9 2 1 0 2 2 2 0 Conserved hypothetical ATP binding protein AAA_14 PF13173.6 CAV19940.1 - 0.064 13.3 0.0 0.18 11.8 0.0 1.9 2 1 0 2 2 2 0 AAA domain Sigma54_activat PF00158.26 CAV19940.1 - 0.067 12.9 0.1 0.28 10.9 0.0 1.9 2 0 0 2 2 2 0 Sigma-54 interaction domain DUF2075 PF09848.9 CAV19940.1 - 0.095 11.9 0.0 0.18 11.0 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) NACHT PF05729.12 CAV19940.1 - 0.15 11.9 0.0 0.39 10.6 0.0 1.7 1 0 0 1 1 1 0 NACHT domain AAA_33 PF13671.6 CAV19940.1 - 0.17 12.0 0.3 0.35 11.0 0.3 1.6 1 1 0 1 1 1 0 AAA domain Ala_racemase_N PF01168.20 CAV19942.1 - 7.1e-32 110.8 0.0 8.7e-32 110.5 0.0 1.0 1 0 0 1 1 1 1 Alanine racemase, N-terminal domain ABC_tran_CTD PF16326.5 CAV19942.1 - 0.07 13.4 0.2 1.5 9.2 0.1 2.3 2 0 0 2 2 2 0 ABC transporter C-terminal domain DHR-2 PF06920.13 CAV19942.1 - 0.12 11.0 0.0 0.74 8.4 0.0 2.0 1 1 1 2 2 2 0 Dock homology region 2 Orn_Arg_deC_N PF02784.16 CAV19942.1 - 0.14 11.5 0.0 0.27 10.6 0.0 1.4 1 0 0 1 1 1 0 Pyridoxal-dependent decarboxylase, pyridoxal binding domain P5CR_dimer PF14748.6 CAV19944.1 - 2.7e-30 104.7 4.3 2.7e-30 104.7 4.3 1.8 2 0 0 2 2 2 1 Pyrroline-5-carboxylate reductase dimerisation F420_oxidored PF03807.17 CAV19944.1 - 5e-25 87.9 1.7 1e-24 86.9 0.2 2.1 2 1 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent NAD_Gly3P_dh_N PF01210.23 CAV19944.1 - 0.00024 21.1 0.5 0.00066 19.7 0.5 1.8 1 1 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus PDH PF02153.17 CAV19944.1 - 0.0033 16.5 0.0 0.005 15.9 0.0 1.3 1 0 0 1 1 1 1 Prephenate dehydrogenase Shikimate_DH PF01488.20 CAV19944.1 - 0.0048 17.0 0.9 0.013 15.6 0.1 2.1 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase NAD_binding_2 PF03446.15 CAV19944.1 - 0.015 15.5 0.0 0.029 14.5 0.0 1.5 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase ApbA PF02558.16 CAV19944.1 - 0.13 11.9 2.4 0.2 11.3 0.9 2.1 2 1 0 2 2 2 0 Ketopantoate reductase PanE/ApbA Rossmann-like PF10727.9 CAV19944.1 - 0.19 11.6 1.6 4.7 7.1 0.1 2.7 2 1 0 2 2 2 0 Rossmann-like domain YGGT PF02325.17 CAV19945.1 - 9.8e-39 131.6 23.2 2.6e-20 72.6 4.4 2.9 1 1 2 3 3 3 2 YGGT family DUF167 PF02594.16 CAV19947.1 - 2.9e-26 91.4 0.1 3.4e-26 91.2 0.1 1.1 1 0 0 1 1 1 1 Uncharacterised ACR, YggU family COG1872 PhzC-PhzF PF02567.16 CAV19947.1 - 0.05 13.1 0.0 0.058 12.9 0.0 1.1 1 0 0 1 1 1 0 Phenazine biosynthesis-like protein DUF4426 PF14467.6 CAV19949.1 - 6.1e-48 161.8 0.1 7e-48 161.6 0.1 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4426) Ham1p_like PF01725.16 CAV19951.1 - 2.6e-63 213.3 0.0 2.9e-63 213.2 0.0 1.0 1 0 0 1 1 1 1 Ham1 family LytR_C PF13399.6 CAV19951.1 - 0.018 16.0 0.1 0.034 15.1 0.1 1.6 1 1 0 1 1 1 0 LytR cell envelope-related transcriptional attenuator Radical_SAM PF04055.21 CAV19953.1 - 5.2e-18 66.0 0.0 8.3e-18 65.3 0.0 1.3 1 0 0 1 1 1 1 Radical SAM superfamily HemN_C PF06969.16 CAV19953.1 - 3.8e-11 42.9 0.0 3.5e-10 39.8 0.0 2.7 3 0 0 3 3 3 1 HemN C-terminal domain HTH_45 PF14947.6 CAV19953.1 - 0.0096 15.9 0.0 0.072 13.1 0.0 2.2 2 0 0 2 2 2 1 Winged helix-turn-helix Fer4_14 PF13394.6 CAV19953.1 - 0.047 13.8 0.0 0.082 13.1 0.0 1.4 1 0 0 1 1 1 0 4Fe-4S single cluster domain TPR_1 PF00515.28 CAV19953.1 - 0.076 12.9 0.0 0.17 11.7 0.0 1.6 1 0 0 1 1 1 0 Tetratricopeptide repeat Fer4_12 PF13353.6 CAV19953.1 - 0.08 13.2 0.0 0.84 9.9 0.0 2.1 2 0 0 2 2 2 0 4Fe-4S single cluster domain AAA_assoc_C PF09821.9 CAV19953.1 - 0.084 13.4 0.0 0.27 11.8 0.0 1.8 2 0 0 2 2 2 0 C-terminal AAA-associated domain Glutaminase PF04960.15 CAV19955.1 - 3.8e-112 374.1 0.1 4.3e-112 374.0 0.1 1.0 1 0 0 1 1 1 1 Glutaminase Methyltransf_4 PF02390.17 CAV19956.1 - 1.3e-57 194.0 0.0 1.8e-57 193.6 0.0 1.2 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_25 PF13649.6 CAV19956.1 - 0.0012 19.5 0.0 0.0059 17.3 0.1 2.2 2 1 1 3 3 3 1 Methyltransferase domain Methyltransf_3 PF01596.17 CAV19956.1 - 0.058 12.6 0.0 0.08 12.1 0.0 1.3 1 0 0 1 1 1 0 O-methyltransferase Methyltransf_31 PF13847.6 CAV19956.1 - 0.07 12.9 0.0 0.41 10.4 0.0 2.0 2 0 0 2 2 2 0 Methyltransferase domain NUDIX_4 PF14815.6 CAV19958.1 - 7.5e-23 80.6 0.1 2.4e-22 79.0 0.0 1.9 2 0 0 2 2 2 1 NUDIX domain HhH-GPD PF00730.25 CAV19958.1 - 5.3e-21 75.1 0.0 7.9e-21 74.5 0.0 1.3 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein HHH PF00633.23 CAV19958.1 - 6.1e-07 29.0 0.0 1.2e-06 28.1 0.0 1.5 1 0 0 1 1 1 1 Helix-hairpin-helix motif HHH_5 PF14520.6 CAV19958.1 - 0.011 16.3 0.0 0.24 12.0 0.0 2.4 2 0 0 2 2 2 0 Helix-hairpin-helix domain Whib PF02467.16 CAV19958.1 - 0.014 16.0 1.1 2.2 9.0 0.5 2.5 2 0 0 2 2 2 0 Transcription factor WhiB EndIII_4Fe-2S PF10576.9 CAV19958.1 - 0.017 15.4 5.4 0.032 14.6 5.4 1.5 1 0 0 1 1 1 0 Iron-sulfur binding domain of endonuclease III Iron_traffic PF04362.14 CAV19960.1 - 2.2e-41 139.4 0.0 2.4e-41 139.3 0.0 1.0 1 0 0 1 1 1 1 Bacterial Fe(2+) trafficking DUF5412 PF17428.2 CAV19960.1 - 0.091 12.6 0.1 0.12 12.2 0.1 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5412) NMD3 PF04981.13 CAV19960.1 - 0.14 11.6 0.0 0.16 11.4 0.0 1.1 1 0 0 1 1 1 0 NMD3 family Mltc_N PF11873.8 CAV19962.1 - 3.8e-68 228.3 0.9 5.3e-68 227.9 0.9 1.2 1 0 0 1 1 1 1 Membrane-bound lytic murein transglycosylase C, N-terminal domain SLT PF01464.20 CAV19962.1 - 1.2e-29 102.3 0.0 1.9e-29 101.7 0.0 1.3 1 0 0 1 1 1 1 Transglycosylase SLT domain SLT_2 PF13406.6 CAV19962.1 - 0.0019 17.5 1.6 0.0051 16.1 0.1 2.2 2 1 1 3 3 3 1 Transglycosylase SLT domain RE_CfrBI PF09516.10 CAV19965.1 - 0.052 13.0 0.3 0.053 12.9 0.3 1.0 1 0 0 1 1 1 0 CfrBI restriction endonuclease MCPsignal PF00015.21 CAV19967.1 - 4.3e-41 140.6 38.3 5.2e-41 140.3 23.4 2.8 1 1 1 2 2 2 2 Methyl-accepting chemotaxis protein (MCP) signalling domain sCache_2 PF17200.4 CAV19967.1 - 4.7e-34 117.5 0.2 4.7e-34 117.5 0.2 2.9 3 0 0 3 3 3 1 Single Cache domain 2 dCache_2 PF08269.11 CAV19967.1 - 3.5e-20 72.4 0.1 3.5e-20 72.4 0.1 3.4 2 1 2 4 4 4 1 Cache domain BAR_2 PF10455.9 CAV19967.1 - 0.012 14.8 10.9 0.13 11.3 2.3 2.7 2 1 1 3 3 3 0 Bin/amphiphysin/Rvs domain for vesicular trafficking DUF4200 PF13863.6 CAV19967.1 - 0.17 12.3 4.7 1.3 9.5 0.1 3.0 2 1 1 3 3 3 0 Domain of unknown function (DUF4200) Alpha-2-MRAP_C PF06401.11 CAV19967.1 - 0.2 11.6 5.9 0.81 9.6 1.5 2.4 2 0 0 2 2 2 0 Alpha-2-macroglobulin RAP, C-terminal domain UPF0242 PF06785.11 CAV19967.1 - 1.7 8.7 11.7 0.31 11.1 0.7 3.1 3 0 0 3 3 3 0 Uncharacterised protein family (UPF0242) N-terminus DUF1664 PF07889.12 CAV19967.1 - 1.7 8.7 22.0 1.5 8.9 3.1 4.5 2 2 2 4 4 4 0 Protein of unknown function (DUF1664) CLZ PF16526.5 CAV19967.1 - 2.6 8.5 10.7 4.7 7.6 0.4 3.7 4 0 0 4 4 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Fib_alpha PF08702.10 CAV19967.1 - 2.8 8.1 21.9 0.16 12.2 2.9 3.7 2 2 0 2 2 2 0 Fibrinogen alpha/beta chain family Hormone_1 PF00103.20 CAV19967.1 - 3.5 7.3 11.1 2.7 7.7 1.4 3.3 2 1 1 3 3 3 0 Somatotropin hormone family DUF948 PF06103.11 CAV19967.1 - 3.8 7.9 30.5 1.8 8.9 3.0 5.4 3 2 1 4 4 4 0 Bacterial protein of unknown function (DUF948) COG2 PF06148.11 CAV19967.1 - 4.1 7.5 13.1 6.2 6.9 0.6 4.0 2 1 2 4 4 4 0 COG (conserved oligomeric Golgi) complex component, COG2 BLOC1_2 PF10046.9 CAV19967.1 - 4.4 7.7 21.4 2.7 8.3 0.4 4.7 2 2 2 4 4 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Mce4_CUP1 PF11887.8 CAV19967.1 - 5.9 6.3 19.2 0.49 9.8 4.3 2.6 1 1 0 2 2 2 0 Cholesterol uptake porter CUP1 of Mce4, putative DUF2391 PF09622.10 CAV19968.1 - 2.8e-09 36.7 2.2 3.3e-09 36.5 2.2 1.0 1 0 0 1 1 1 1 Putative integral membrane protein (DUF2391) DUF3391 PF11871.8 CAV19972.1 - 4.8e-30 104.9 0.1 8e-30 104.2 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3391) HD PF01966.22 CAV19972.1 - 5.9e-16 58.8 0.0 1.2e-15 57.8 0.0 1.5 1 0 0 1 1 1 1 HD domain HD_5 PF13487.6 CAV19972.1 - 5.6e-14 52.2 0.0 1.1e-13 51.3 0.0 1.5 1 0 0 1 1 1 1 HD domain HDOD PF08668.12 CAV19972.1 - 0.0053 16.3 0.0 0.0095 15.4 0.0 1.4 1 0 0 1 1 1 1 HDOD domain 3-dmu-9_3-mt PF06983.13 CAV19974.1 - 6.7e-12 46.0 0.0 8.2e-12 45.7 0.0 1.1 1 0 0 1 1 1 1 3-demethylubiquinone-9 3-methyltransferase Glyoxalase PF00903.25 CAV19974.1 - 2.5e-09 37.4 0.0 3.7e-09 36.9 0.0 1.2 1 0 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily RDD PF06271.12 CAV19976.1 - 4.3e-22 78.8 8.8 7.6e-22 78.0 8.8 1.4 1 1 0 1 1 1 1 RDD family Anoctamin PF04547.12 CAV19976.1 - 0.053 12.4 1.6 0.061 12.1 1.6 1.1 1 0 0 1 1 1 0 Calcium-activated chloride channel UPF0697 PF15117.6 CAV19976.1 - 0.17 12.0 0.1 0.47 10.6 0.1 1.8 2 0 0 2 2 2 0 Uncharacterised protein family UPF0697 LptF_LptG PF03739.14 CAV19977.1 - 3.1e-66 223.7 9.9 3.5e-66 223.5 9.9 1.0 1 0 0 1 1 1 1 Lipopolysaccharide export system permease LptF/LptG E1-E2_ATPase PF00122.20 CAV19977.1 - 0.38 10.3 6.4 2.3 7.7 0.4 2.5 2 0 0 2 2 2 0 E1-E2 ATPase LptF_LptG PF03739.14 CAV19979.1 - 1.8e-71 240.9 1.8 2.3e-71 240.5 1.8 1.0 1 0 0 1 1 1 1 Lipopolysaccharide export system permease LptF/LptG DUF3221 PF11518.8 CAV19979.1 - 0.12 12.7 0.0 0.25 11.7 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3221) LMBR1 PF04791.16 CAV19979.1 - 1.6 7.5 6.4 0.69 8.8 3.3 1.8 2 0 0 2 2 2 0 LMBR1-like membrane protein Peptidase_M17_N PF02789.17 CAV19981.1 - 3.3e-35 120.7 0.0 4.5e-35 120.3 0.0 1.2 1 0 0 1 1 1 1 Cytosol aminopeptidase family, N-terminal domain Peptidase_M17 PF00883.21 CAV19983.1 - 1.2e-114 382.8 0.9 1.4e-114 382.6 0.9 1.0 1 0 0 1 1 1 1 Cytosol aminopeptidase family, catalytic domain DNA_pol3_chi PF04364.13 CAV19984.1 - 1.8e-32 112.3 0.2 2e-32 112.2 0.2 1.0 1 0 0 1 1 1 1 DNA polymerase III chi subunit, HolC Ovate PF04844.13 CAV19984.1 - 0.04 13.9 0.6 2.7 8.1 0.0 2.2 2 0 0 2 2 2 0 Transcriptional repressor, ovate GlgS PF08971.11 CAV19984.1 - 0.088 12.8 0.7 0.34 11.0 0.2 2.1 2 0 0 2 2 2 0 Glycogen synthesis protein tRNA-synt_1 PF00133.22 CAV19986.1 - 1.8e-224 746.5 4.8 2e-223 743.1 2.7 2.7 2 1 0 2 2 2 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 CAV19986.1 - 4.9e-40 137.0 0.9 9.8e-40 136.0 0.9 1.5 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA Val_tRNA-synt_C PF10458.9 CAV19986.1 - 1.8e-18 66.6 4.1 3.7e-18 65.5 4.1 1.6 1 0 0 1 1 1 1 Valyl tRNA synthetase tRNA binding arm tRNA-synt_1g PF09334.11 CAV19986.1 - 1.3e-15 57.0 1.9 2e-06 26.8 0.1 4.8 4 1 0 4 4 4 4 tRNA synthetases class I (M) tRNA-synt_1_2 PF13603.6 CAV19986.1 - 1.1e-07 31.5 0.0 3.3e-05 23.5 0.0 2.7 1 1 1 2 2 2 2 Leucyl-tRNA synthetase, Domain 2 DUF2061 PF09834.9 CAV19990.1 - 3.7e-42 142.6 14.0 4e-21 75.3 3.2 2.1 2 0 0 2 2 2 2 Predicted membrane protein (DUF2061) Kindlin_2_N PF18124.1 CAV19990.1 - 0.00096 19.3 0.0 0.32 11.2 0.0 2.2 1 1 1 2 2 2 2 Kindlin-2 N-terminal domain PTS_EIIC PF02378.18 CAV19990.1 - 0.054 12.5 4.2 0.025 13.6 1.7 1.6 1 1 1 2 2 2 0 Phosphotransferase system, EIIC Acetyltransf_1 PF00583.25 CAV19992.1 - 2.6e-16 59.9 0.0 6e-16 58.7 0.0 1.6 2 0 0 2 2 1 1 Acetyltransferase (GNAT) family MarR_2 PF12802.7 CAV19992.1 - 8.9e-14 51.1 0.0 2.2e-13 49.9 0.0 1.7 1 0 0 1 1 1 1 MarR family Acetyltransf_7 PF13508.7 CAV19992.1 - 4.7e-13 49.4 0.0 1.2e-12 48.1 0.0 1.7 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain MarR PF01047.22 CAV19992.1 - 6.8e-12 45.1 0.0 1.7e-11 43.9 0.0 1.8 1 0 0 1 1 1 1 MarR family Acetyltransf_10 PF13673.7 CAV19992.1 - 2e-09 37.4 0.0 4.1e-09 36.4 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain HTH_27 PF13463.6 CAV19992.1 - 5.4e-07 30.0 0.0 1.4e-06 28.7 0.0 1.8 1 0 0 1 1 1 1 Winged helix DNA-binding domain FR47 PF08445.10 CAV19992.1 - 2.1e-06 27.6 0.0 5.9e-06 26.2 0.0 1.7 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_3 PF13302.7 CAV19992.1 - 2.9e-06 28.0 0.0 4.7e-06 27.3 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 CAV19992.1 - 4.3e-05 23.7 0.0 8.6e-05 22.7 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Fe_dep_repress PF01325.19 CAV19992.1 - 0.00014 22.0 0.0 0.00078 19.6 0.0 2.2 2 0 0 2 2 2 1 Iron dependent repressor, N-terminal DNA binding domain TrmB PF01978.19 CAV19992.1 - 0.00039 20.2 0.0 0.00094 19.0 0.0 1.6 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB HTH_24 PF13412.6 CAV19992.1 - 0.0006 19.3 0.1 0.0018 17.8 0.1 1.8 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding Acetyltransf_9 PF13527.7 CAV19992.1 - 0.00097 19.2 0.2 0.0075 16.3 0.1 2.3 3 0 0 3 3 2 1 Acetyltransferase (GNAT) domain HTH_IclR PF09339.10 CAV19992.1 - 0.0011 18.7 0.1 0.0037 17.0 0.0 2.0 2 0 0 2 2 2 1 IclR helix-turn-helix domain HTH_5 PF01022.20 CAV19992.1 - 0.0027 17.5 0.1 0.012 15.5 0.0 2.1 2 0 0 2 2 2 1 Bacterial regulatory protein, arsR family Rrf2 PF02082.20 CAV19992.1 - 0.0029 17.9 0.3 0.015 15.6 0.1 2.1 2 0 0 2 2 2 1 Transcriptional regulator HTH_20 PF12840.7 CAV19992.1 - 0.0052 16.8 0.0 0.013 15.5 0.0 1.6 1 0 0 1 1 1 1 Helix-turn-helix domain Gly_acyl_tr_C PF08444.10 CAV19992.1 - 0.01 16.0 0.6 0.047 13.9 0.0 2.4 2 1 1 3 3 3 0 Aralkyl acyl-CoA:amino acid N-acyltransferase, C-terminal region HTH_Crp_2 PF13545.6 CAV19992.1 - 0.017 15.1 0.0 0.037 14.0 0.0 1.6 1 0 0 1 1 1 0 Crp-like helix-turn-helix domain Sigma54_DBD PF04552.13 CAV19992.1 - 0.026 14.2 0.4 0.13 12.0 0.0 2.0 2 0 0 2 2 2 0 Sigma-54, DNA binding domain GntR PF00392.21 CAV19992.1 - 0.048 13.3 0.0 0.15 11.7 0.0 1.8 2 0 0 2 2 1 0 Bacterial regulatory proteins, gntR family Peptidase_M7 PF02031.16 CAV19992.1 - 0.056 13.6 0.0 0.094 12.8 0.0 1.3 1 0 0 1 1 1 0 Streptomyces extracellular neutral proteinase (M7) family HTH_34 PF13601.6 CAV19992.1 - 0.071 13.3 0.1 0.2 11.9 0.0 1.8 2 0 0 2 2 1 0 Winged helix DNA-binding domain MHB PF16525.5 CAV19992.1 - 0.083 13.1 1.0 0.21 11.8 1.0 1.7 1 0 0 1 1 1 0 Haemophore, haem-binding HTH_11 PF08279.12 CAV19992.1 - 0.1 12.6 0.1 0.27 11.2 0.1 1.8 1 0 0 1 1 1 0 HTH domain Acetyltransf_CG PF14542.6 CAV19992.1 - 0.12 12.6 0.0 0.24 11.6 0.0 1.5 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase HTH_36 PF13730.6 CAV19992.1 - 0.12 12.4 0.0 0.28 11.2 0.0 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_45 PF14947.6 CAV19992.1 - 0.12 12.4 0.0 0.26 11.3 0.0 1.5 1 0 0 1 1 1 0 Winged helix-turn-helix HTH_AraC PF00165.23 CAV19992.1 - 0.15 12.2 0.0 0.37 11.0 0.0 1.7 1 0 0 1 1 1 0 Bacterial regulatory helix-turn-helix proteins, AraC family Glyco_hydro_2_N PF02837.18 CAV19994.1 - 5.5e-05 23.1 0.0 0.0007 19.5 0.0 2.1 2 0 0 2 2 2 1 Glycosyl hydrolases family 2, sugar binding domain RraB PF06877.11 CAV19996.1 - 1.4e-32 112.5 1.9 1.4e-32 112.5 1.9 1.4 2 0 0 2 2 2 1 Regulator of ribonuclease activity B Amidinotransf PF02274.17 CAV19998.1 - 1.3e-108 363.1 0.0 1.5e-108 363.0 0.0 1.0 1 0 0 1 1 1 1 Amidinotransferase OTCace PF00185.24 CAV20000.1 - 4.1e-56 189.4 0.3 7.5e-56 188.6 0.3 1.4 2 0 0 2 2 2 1 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain OTCace_N PF02729.21 CAV20000.1 - 9.3e-45 152.3 0.0 1.4e-44 151.7 0.0 1.3 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain OTCace_N PF02729.21 CAV20002.1 - 3.4e-44 150.4 0.0 5.2e-44 149.8 0.0 1.3 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain OTCace PF00185.24 CAV20002.1 - 5.4e-33 114.3 0.0 8.2e-33 113.7 0.0 1.3 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain PyrI PF01948.18 CAV20004.1 - 5.1e-30 103.6 0.3 7.3e-30 103.1 0.3 1.2 1 0 0 1 1 1 1 Aspartate carbamoyltransferase regulatory chain, allosteric domain PyrI_C PF02748.15 CAV20004.1 - 1e-18 67.0 7.5 1e-18 67.0 7.5 1.6 2 0 0 2 2 2 1 Aspartate carbamoyltransferase regulatory chain, metal binding domain Elf1 PF05129.13 CAV20004.1 - 0.033 14.2 1.2 0.06 13.4 1.2 1.4 1 0 0 1 1 1 0 Transcription elongation factor Elf1 like zf-BED PF02892.15 CAV20004.1 - 0.036 14.1 0.2 0.072 13.1 0.2 1.5 1 0 0 1 1 1 0 BED zinc finger Rota_Capsid_VP6 PF00980.17 CAV20004.1 - 0.12 11.3 0.0 0.15 11.0 0.0 1.1 1 0 0 1 1 1 0 Rotavirus major capsid protein VP6 zf-H2C2_2 PF13465.6 CAV20004.1 - 0.88 10.1 3.4 0.71 10.4 0.5 2.1 2 0 0 2 2 2 0 Zinc-finger double domain Ribonuc_L-PSP PF01042.21 CAV20006.1 - 1.9e-44 150.5 0.3 2.2e-44 150.4 0.3 1.0 1 0 0 1 1 1 1 Endoribonuclease L-PSP Acyltransferase PF01553.21 CAV20008.1 - 3.7e-31 107.5 0.0 5.4e-31 107.0 0.0 1.2 1 0 0 1 1 1 1 Acyltransferase EPSP_synthase PF00275.20 CAV20010.1 - 6.4e-122 407.2 2.0 7.2e-122 407.1 2.0 1.0 1 0 0 1 1 1 1 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) Phage_gp49_66 PF13876.6 CAV20010.1 - 0.0054 17.0 0.0 0.012 15.9 0.0 1.5 1 0 0 1 1 1 1 Phage protein (N4 Gp49/phage Sf6 gene 66) family YvfG PF09628.10 CAV20010.1 - 0.21 12.0 0.1 1.2 9.6 0.0 2.2 2 0 0 2 2 2 0 YvfG protein BolA PF01722.18 CAV20012.1 - 5.4e-14 52.2 0.0 7.1e-14 51.8 0.0 1.2 1 1 0 1 1 1 1 BolA-like protein TrmK PF04816.12 CAV20012.1 - 0.029 13.9 0.0 0.03 13.8 0.0 1.1 1 0 0 1 1 1 0 tRNA (adenine(22)-N(1))-methyltransferase GP70 PF17429.2 CAV20012.1 - 0.12 12.2 0.0 0.21 11.5 0.0 1.3 1 0 0 1 1 1 0 Gene product 70 STAS_2 PF13466.6 CAV20014.1 - 3.2e-18 65.8 0.0 3.8e-18 65.6 0.0 1.1 1 0 0 1 1 1 1 STAS domain STAS PF01740.21 CAV20014.1 - 2.5e-07 30.4 0.0 2.7e-07 30.2 0.0 1.1 1 0 0 1 1 1 1 STAS domain DUF1987 PF09345.10 CAV20014.1 - 0.0088 15.7 0.0 0.012 15.3 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF1987) MlaC PF05494.12 CAV20016.1 - 3.1e-45 153.9 0.3 3.8e-45 153.6 0.3 1.1 1 0 0 1 1 1 1 MlaC protein MlaD PF02470.20 CAV20018.1 - 1.4e-20 73.4 0.1 1.9e-20 72.9 0.1 1.2 1 0 0 1 1 1 1 MlaD protein MlaE PF02405.16 CAV20020.1 - 6e-75 251.5 13.9 7.3e-75 251.3 13.9 1.1 1 0 0 1 1 1 1 Permease MlaE ABC_tran PF00005.27 CAV20022.1 - 3.3e-29 102.2 0.0 5.2e-29 101.5 0.0 1.3 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 CAV20022.1 - 7.5e-05 22.7 0.1 0.075 12.8 0.0 2.3 1 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system ABC_ATPase PF09818.9 CAV20022.1 - 0.00016 20.6 1.2 0.11 11.3 0.0 2.2 2 0 0 2 2 2 2 Predicted ATPase of the ABC class RsgA_GTPase PF03193.16 CAV20022.1 - 0.00025 21.0 0.0 0.0004 20.3 0.0 1.3 1 0 0 1 1 1 1 RsgA GTPase AAA_16 PF13191.6 CAV20022.1 - 0.00065 20.1 0.0 0.00095 19.6 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 CAV20022.1 - 0.00091 19.5 0.1 0.0015 18.8 0.1 1.6 1 1 0 1 1 1 1 AAA domain AAA_23 PF13476.6 CAV20022.1 - 0.006 17.1 0.1 0.0093 16.5 0.1 1.2 1 0 0 1 1 1 1 AAA domain AAA_29 PF13555.6 CAV20022.1 - 0.0074 16.0 0.0 0.015 15.1 0.0 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_14 PF13173.6 CAV20022.1 - 0.019 15.0 0.0 0.061 13.4 0.0 1.9 3 0 0 3 3 2 0 AAA domain AAA_24 PF13479.6 CAV20022.1 - 0.032 13.9 0.1 0.05 13.3 0.1 1.3 1 0 0 1 1 1 0 AAA domain AAA_3 PF07726.11 CAV20022.1 - 0.042 13.7 0.0 0.11 12.3 0.0 1.7 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_25 PF13481.6 CAV20022.1 - 0.052 13.1 0.0 0.24 11.0 0.0 1.9 2 0 0 2 2 2 0 AAA domain DUF5122 PF17164.4 CAV20022.1 - 0.064 13.6 0.0 0.14 12.5 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF5122) beta-propeller NACHT PF05729.12 CAV20022.1 - 0.23 11.3 0.6 0.46 10.4 0.6 1.5 1 0 0 1 1 1 0 NACHT domain Na_Ca_ex PF01699.24 CAV20023.1 - 1.6e-54 184.0 35.9 6.7e-28 97.5 13.5 2.0 2 0 0 2 2 2 2 Sodium/calcium exchanger protein SIS PF01380.22 CAV20025.1 - 1.3e-31 109.2 0.1 2e-31 108.6 0.1 1.2 1 0 0 1 1 1 1 SIS domain CBS PF00571.28 CAV20025.1 - 6e-12 45.8 1.3 7.7e-05 23.1 0.1 2.8 3 0 0 3 3 3 2 CBS domain SIS_2 PF13580.6 CAV20025.1 - 0.00048 20.2 0.8 0.016 15.3 0.1 2.5 1 1 1 2 2 2 1 SIS domain Hydrolase_3 PF08282.12 CAV20027.1 - 6.2e-14 52.3 0.1 1e-09 38.5 0.0 2.1 1 1 1 2 2 2 2 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 CAV20027.1 - 3.7e-07 30.4 0.1 4.8e-07 30.0 0.1 1.3 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 CAV20027.1 - 6.9e-05 23.2 0.3 0.00027 21.3 0.1 1.8 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase DUF1828 PF08861.10 CAV20027.1 - 0.16 12.3 0.0 0.29 11.4 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function DUF1828 S6PP PF05116.13 CAV20027.1 - 0.17 11.4 0.0 0.78 9.2 0.0 1.8 2 0 0 2 2 2 0 Sucrose-6F-phosphate phosphohydrolase LptC PF06835.13 CAV20028.1 - 1.7e-45 154.8 0.1 1.9e-45 154.6 0.1 1.0 1 0 0 1 1 1 1 Lipopolysaccharide-assembly, LptC-related DUF5003 PF16394.5 CAV20028.1 - 0.0064 15.7 0.3 0.008 15.4 0.3 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF5003) OstA PF03968.14 CAV20030.1 - 1.1e-28 99.7 1.8 1.4e-28 99.4 1.8 1.1 1 0 0 1 1 1 1 OstA-like protein bPH_1 PF08000.11 CAV20030.1 - 0.013 15.6 0.1 0.031 14.4 0.0 1.7 2 0 0 2 2 2 0 Bacterial PH domain DUF2140 PF09911.9 CAV20030.1 - 0.044 13.3 0.3 0.077 12.5 0.3 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2140) LptC PF06835.13 CAV20030.1 - 0.058 13.0 0.9 2.5 7.7 0.1 2.2 2 0 0 2 2 2 0 Lipopolysaccharide-assembly, LptC-related ABC_tran PF00005.27 CAV20032.1 - 2.4e-34 118.8 0.0 3.9e-34 118.1 0.0 1.3 1 0 0 1 1 1 1 ABC transporter BCA_ABC_TP_C PF12399.8 CAV20032.1 - 2.8e-09 36.7 0.0 5.2e-09 35.8 0.0 1.5 1 0 0 1 1 1 1 Branched-chain amino acid ATP-binding cassette transporter AAA_21 PF13304.6 CAV20032.1 - 0.00012 22.0 0.4 0.031 14.1 0.0 2.1 1 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 CAV20032.1 - 0.0088 15.5 0.2 2.8 7.3 0.0 2.1 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 CAV20032.1 - 0.052 14.1 0.3 0.14 12.6 0.1 1.7 2 0 0 2 2 2 0 AAA domain AAA_24 PF13479.6 CAV20032.1 - 0.06 13.1 0.0 0.097 12.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain T2SSE PF00437.20 CAV20032.1 - 0.064 12.3 0.1 0.097 11.7 0.1 1.5 1 1 0 1 1 1 0 Type II/IV secretion system protein SbcCD_C PF13558.6 CAV20032.1 - 0.089 13.0 0.3 1 9.6 0.1 2.6 2 1 0 2 2 2 0 Putative exonuclease SbcCD, C subunit Sigma54_DBD PF04552.13 CAV20034.1 - 8.7e-72 240.1 0.3 1.4e-71 239.4 0.3 1.3 1 0 0 1 1 1 1 Sigma-54, DNA binding domain Sigma54_CBD PF04963.13 CAV20034.1 - 2.5e-57 193.6 0.3 2.5e-57 193.6 0.3 1.9 2 0 0 2 2 2 1 Sigma-54 factor, core binding domain Sigma54_AID PF00309.20 CAV20034.1 - 2.3e-17 62.6 14.5 6.1e-17 61.2 14.5 1.8 1 0 0 1 1 1 1 Sigma-54 factor, Activator interacting domain (AID) rve PF00665.26 CAV20034.1 - 0.037 14.2 0.1 22 5.3 0.0 3.1 2 1 1 3 3 3 0 Integrase core domain HTH_21 PF13276.6 CAV20034.1 - 0.076 13.2 0.0 0.22 11.7 0.0 1.8 1 0 0 1 1 1 0 HTH-like domain TrmO_C PF18389.1 CAV20034.1 - 0.49 10.5 7.4 4 7.6 0.2 3.5 3 0 0 3 3 3 0 TrmO C-terminal domain Ribosomal_S30AE PF02482.19 CAV20035.1 - 2.5e-28 98.7 2.7 2.8e-28 98.5 2.7 1.0 1 0 0 1 1 1 1 Sigma 54 modulation protein / S30EA ribosomal protein HycH PF07450.11 CAV20035.1 - 0.0066 16.8 0.9 0.0082 16.5 0.9 1.1 1 0 0 1 1 1 1 Formate hydrogenlyase maturation protein HycH Clat_adaptor_s PF01217.20 CAV20035.1 - 0.03 14.3 0.3 0.035 14.0 0.3 1.3 1 1 0 1 1 1 0 Clathrin adaptor complex small chain Polyketide_cyc PF03364.20 CAV20035.1 - 0.039 14.2 0.0 0.045 14.0 0.0 1.1 1 0 0 1 1 1 0 Polyketide cyclase / dehydrase and lipid transport PTS_EIIA_2 PF00359.22 CAV20037.1 - 5.2e-38 130.2 0.1 5.6e-38 130.1 0.1 1.0 1 0 0 1 1 1 1 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 ATP_bind_2 PF03668.15 CAV20039.1 - 2.3e-109 365.1 0.0 2.6e-109 364.9 0.0 1.0 1 0 0 1 1 1 1 P-loop ATPase protein family AAA_18 PF13238.6 CAV20039.1 - 0.00011 22.7 0.0 0.00097 19.7 0.0 2.4 2 1 1 3 3 3 1 AAA domain AAA_22 PF13401.6 CAV20039.1 - 0.0059 16.9 0.0 0.013 15.8 0.0 1.7 1 0 0 1 1 1 1 AAA domain NanE PF04131.14 CAV20039.1 - 0.019 14.2 0.0 0.029 13.5 0.0 1.2 1 0 0 1 1 1 0 Putative N-acetylmannosamine-6-phosphate epimerase Zeta_toxin PF06414.12 CAV20039.1 - 0.07 12.4 0.1 0.21 10.8 0.0 1.8 2 0 0 2 2 2 0 Zeta toxin ABC_tran PF00005.27 CAV20039.1 - 0.14 12.7 0.0 0.33 11.5 0.0 1.6 1 1 0 1 1 1 0 ABC transporter PTS-HPr PF00381.19 CAV20041.1 - 3.9e-24 84.7 0.7 4.3e-24 84.6 0.7 1.0 1 0 0 1 1 1 1 PTS HPr component phosphorylation site MgtE_N PF03448.17 CAV20044.1 - 1.6e-25 89.7 4.7 1.6e-25 89.7 4.7 2.8 3 1 0 3 3 3 1 MgtE intracellular N domain MgtE PF01769.16 CAV20044.1 - 3.5e-23 82.3 9.0 6.5e-23 81.5 9.0 1.5 1 0 0 1 1 1 1 Divalent cation transporter CBS PF00571.28 CAV20044.1 - 1.3e-13 51.2 6.3 5.5e-06 26.7 1.4 3.3 1 1 1 2 2 2 2 CBS domain FliG_C PF01706.16 CAV20044.1 - 0.019 15.1 0.2 0.72 10.1 0.1 2.5 1 1 1 2 2 2 0 FliG C-terminal domain FliG_M PF14841.6 CAV20044.1 - 0.064 13.5 0.2 1.8 8.9 0.0 3.2 2 1 1 3 3 3 0 FliG middle domain PmbA_TldD PF01523.16 CAV20046.1 - 2.4e-63 214.6 0.1 4.2e-63 213.8 0.1 1.4 1 0 0 1 1 1 1 Putative modulator of DNA gyrase DUF615 PF04751.14 CAV20047.1 - 4.2e-56 189.2 8.2 4.8e-56 189.0 8.2 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF615) Rnk_N PF14760.6 CAV20047.1 - 0.045 14.2 0.6 0.81 10.2 0.1 2.6 2 0 0 2 2 2 0 Rnk N-terminus NYD-SP28 PF14772.6 CAV20047.1 - 0.17 12.0 5.7 5.2 7.2 3.4 2.9 1 1 1 2 2 2 0 Sperm tail LPP PF04728.13 CAV20047.1 - 0.43 11.0 6.0 1.6 9.2 0.5 2.9 2 2 1 3 3 3 0 Lipoprotein leucine-zipper APG6_N PF17675.1 CAV20047.1 - 9.1 6.8 9.4 58 4.2 9.3 2.4 1 1 0 1 1 1 0 Apg6 coiled-coil region ABC_tran PF00005.27 CAV20048.1 - 5.4e-34 117.7 0.0 8.4e-34 117.0 0.0 1.2 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 CAV20048.1 - 3.9e-08 33.5 0.5 8.6e-05 22.5 0.1 2.1 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 CAV20048.1 - 3e-05 23.6 0.0 0.0024 17.3 0.0 2.1 2 0 0 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 CAV20048.1 - 0.00015 22.0 0.3 0.001 19.4 0.3 2.2 1 1 0 1 1 1 1 AAA domain RsgA_GTPase PF03193.16 CAV20048.1 - 0.0002 21.3 0.0 0.00043 20.2 0.0 1.5 1 0 0 1 1 1 1 RsgA GTPase AAA_29 PF13555.6 CAV20048.1 - 0.00031 20.4 0.0 0.00061 19.5 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_16 PF13191.6 CAV20048.1 - 0.00037 20.9 0.2 0.00065 20.1 0.2 1.7 1 1 0 1 1 1 1 AAA ATPase domain AAA_30 PF13604.6 CAV20048.1 - 0.0013 18.5 0.2 0.0036 17.1 0.1 1.8 1 1 0 1 1 1 1 AAA domain AAA_25 PF13481.6 CAV20048.1 - 0.0017 17.9 0.3 0.15 11.6 0.0 2.3 2 0 0 2 2 2 1 AAA domain SbcCD_C PF13558.6 CAV20048.1 - 0.015 15.5 0.1 0.27 11.5 0.1 2.4 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit AAA_23 PF13476.6 CAV20048.1 - 0.031 14.8 0.0 0.05 14.1 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 CAV20048.1 - 0.049 13.8 0.3 0.5 10.5 0.1 2.1 2 0 0 2 2 2 0 AAA domain ATPase PF06745.13 CAV20048.1 - 0.051 12.9 1.0 5.8 6.2 0.1 3.0 2 1 1 3 3 3 0 KaiC AAA_18 PF13238.6 CAV20048.1 - 0.11 13.1 0.1 2 8.9 0.1 2.2 2 0 0 2 2 2 0 AAA domain AAA_24 PF13479.6 CAV20048.1 - 0.11 12.2 0.2 0.86 9.3 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA PF00004.29 CAV20048.1 - 0.13 12.7 0.1 0.55 10.7 0.0 2.0 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) BPD_transp_1 PF00528.22 CAV20049.1 - 2.6e-13 50.1 28.6 4.5e-09 36.3 5.9 3.3 3 1 0 4 4 4 2 Binding-protein-dependent transport system inner membrane component SBP_bac_6 PF13343.6 CAV20051.1 - 9.1e-23 80.9 0.8 1.1e-22 80.6 0.8 1.1 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_1 PF01547.25 CAV20051.1 - 8.8e-21 75.2 1.2 1.2e-20 74.7 1.2 1.2 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_11 PF13531.6 CAV20051.1 - 1.6e-13 50.9 0.0 2.2e-13 50.5 0.0 1.1 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein Flavoprotein PF02441.19 CAV20052.1 - 4e-25 88.4 0.0 5e-25 88.1 0.0 1.1 1 0 0 1 1 1 1 Flavoprotein ANTAR PF03861.14 CAV20052.1 - 0.065 13.1 0.1 8.3 6.3 0.0 2.3 2 0 0 2 2 2 0 ANTAR domain Mur_ligase_M PF08245.12 CAV20053.1 - 1e-20 74.6 0.0 1.5e-20 74.0 0.0 1.3 1 0 0 1 1 1 1 Mur ligase middle domain Mur_ligase PF01225.25 CAV20053.1 - 2.2e-20 72.8 0.0 4.8e-20 71.7 0.0 1.6 1 0 0 1 1 1 1 Mur ligase family, catalytic domain Mur_ligase_C PF02875.21 CAV20053.1 - 1.9e-10 40.8 0.0 5.5e-10 39.4 0.0 1.8 1 0 0 1 1 1 1 Mur ligase family, glutamate ligase domain DUF370 PF04025.12 CAV20053.1 - 0.017 15.2 0.0 0.034 14.3 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF370) FBPase PF00316.20 CAV20054.1 - 1.8e-78 262.4 0.1 2.2e-78 262.1 0.1 1.1 1 0 0 1 1 1 1 Fructose-1-6-bisphosphatase, N-terminal domain Inositol_P PF00459.25 CAV20054.1 - 0.053 13.0 0.0 0.089 12.3 0.0 1.3 1 0 0 1 1 1 0 Inositol monophosphatase family DUF2799 PF10973.8 CAV20055.1 - 2.9e-20 72.5 1.9 3.6e-20 72.2 1.9 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2799) GGACT PF06094.12 CAV20057.1 - 1.3e-23 83.9 0.1 1.5e-23 83.7 0.1 1.0 1 0 0 1 1 1 1 Gamma-glutamyl cyclotransferase, AIG2-like TamB PF04357.13 CAV20058.1 - 1.9e-65 221.6 6.6 2.8e-62 211.2 0.3 4.7 3 2 1 5 5 5 3 TamB, inner membrane protein subunit of TAM complex T2SSN PF01203.19 CAV20058.1 - 0.002 18.4 10.8 0.092 12.9 0.0 5.7 2 2 5 7 7 7 1 Type II secretion system (T2SS), protein N Bac_surface_Ag PF01103.23 CAV20060.1 - 1.9e-30 106.5 5.7 3.9e-30 105.4 5.7 1.5 1 1 0 1 1 1 1 Surface antigen POTRA_TamA_1 PF17243.2 CAV20060.1 - 6.3e-21 74.2 0.0 2e-20 72.6 0.0 1.9 2 0 0 2 2 2 1 POTRA domain TamA domain 1 POTRA PF07244.15 CAV20060.1 - 6.3e-11 42.7 0.1 0.03 14.9 0.0 3.6 3 0 0 3 3 3 3 Surface antigen variable number repeat Peptidase_M35 PF02102.15 CAV20060.1 - 0.044 12.6 0.0 0.072 12.0 0.0 1.2 1 0 0 1 1 1 0 Deuterolysin metalloprotease (M35) family PG_binding_2 PF08823.11 CAV20060.1 - 0.12 12.8 0.2 3.5 8.0 0.0 2.9 3 0 0 3 3 3 0 Putative peptidoglycan binding domain PMSR PF01625.21 CAV20061.1 - 2.4e-67 225.9 1.5 2.8e-67 225.6 1.5 1.1 1 0 0 1 1 1 1 Peptide methionine sulfoxide reductase YtfJ_HI0045 PF09695.10 CAV20062.1 - 5.9e-74 247.0 2.6 6.8e-74 246.8 2.6 1.0 1 0 0 1 1 1 1 Bacterial protein of unknown function (YtfJ_HI0045) DUF2607 PF10795.9 CAV20063.1 - 3.6e-34 116.8 2.2 4.1e-34 116.6 2.2 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2607) NDUF_B12 PF08122.12 CAV20063.1 - 0.12 12.5 0.0 0.2 11.7 0.0 1.3 1 0 0 1 1 1 0 NADH-ubiquinone oxidoreductase B12 subunit family DUF2796 PF10986.8 CAV20065.1 - 7.7e-41 139.9 88.1 1.5e-27 96.6 30.0 3.4 1 1 2 3 3 3 2 Protein of unknown function (DUF2796) SDA1 PF05285.12 CAV20065.1 - 0.032 13.7 19.1 0.041 13.3 19.1 1.3 1 0 0 1 1 1 0 SDA1 ABC_tran PF00005.27 CAV20066.1 - 2.5e-29 102.6 0.1 3.2e-29 102.2 0.1 1.1 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 CAV20066.1 - 2.3e-10 40.8 0.4 5.4e-06 26.4 0.1 2.1 1 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_16 PF13191.6 CAV20066.1 - 2.3e-05 24.8 0.2 4.5e-05 23.9 0.2 1.4 1 1 0 1 1 1 1 AAA ATPase domain Rad17 PF03215.15 CAV20066.1 - 6.5e-05 22.9 0.1 0.00059 19.8 0.0 2.1 1 1 1 2 2 2 1 Rad17 P-loop domain AAA_22 PF13401.6 CAV20066.1 - 0.00019 21.7 1.6 0.004 17.4 1.6 2.2 1 1 0 1 1 1 1 AAA domain RsgA_GTPase PF03193.16 CAV20066.1 - 0.00069 19.6 0.0 0.0017 18.3 0.0 1.7 2 0 0 2 2 2 1 RsgA GTPase AAA_30 PF13604.6 CAV20066.1 - 0.0013 18.5 0.0 0.035 13.8 0.0 2.1 2 0 0 2 2 2 1 AAA domain SMC_N PF02463.19 CAV20066.1 - 0.002 17.6 0.6 0.032 13.7 0.6 2.1 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 CAV20066.1 - 0.0048 16.6 0.0 0.01 15.6 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_33 PF13671.6 CAV20066.1 - 0.0064 16.7 0.0 0.014 15.5 0.0 1.6 1 1 0 1 1 1 1 AAA domain AAA_14 PF13173.6 CAV20066.1 - 0.0091 16.0 0.0 0.028 14.5 0.0 1.7 2 0 0 2 2 2 1 AAA domain IstB_IS21 PF01695.17 CAV20066.1 - 0.01 15.6 0.0 0.38 10.5 0.0 2.2 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA_18 PF13238.6 CAV20066.1 - 0.042 14.4 0.2 0.36 11.4 0.1 2.2 2 1 0 2 2 2 0 AAA domain AAA_5 PF07728.14 CAV20066.1 - 0.067 13.2 0.7 0.18 11.8 0.1 1.9 2 1 0 2 2 2 0 AAA domain (dynein-related subfamily) PhoH PF02562.16 CAV20066.1 - 0.069 12.6 0.1 0.23 10.9 0.0 1.8 2 0 0 2 2 2 0 PhoH-like protein ATPase_2 PF01637.18 CAV20066.1 - 0.12 12.3 0.2 0.25 11.2 0.2 1.8 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_23 PF13476.6 CAV20066.1 - 1.5 9.3 4.8 2.5 8.6 0.3 2.5 1 1 2 3 3 3 0 AAA domain MacB_PCD PF12704.7 CAV20067.1 - 9e-14 52.3 6.1 1.9e-11 44.7 0.1 2.5 2 0 0 2 2 2 2 MacB-like periplasmic core domain FtsX PF02687.21 CAV20067.1 - 6.8e-12 45.7 4.7 6.8e-12 45.7 4.7 2.8 3 0 0 3 3 3 1 FtsX-like permease family DUF3299 PF11736.8 CAV20069.1 - 4.5e-44 149.8 0.0 5.3e-44 149.6 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3299) DUF2806 PF10987.8 CAV20070.1 - 6.8e-84 281.2 0.0 8.4e-84 280.9 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2806) DUF4393 PF14337.6 CAV20070.1 - 0.02 14.7 0.0 0.038 13.8 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4393) PqqD PF05402.12 CAV20070.1 - 0.11 12.8 0.0 0.22 11.9 0.0 1.4 1 0 0 1 1 1 0 Coenzyme PQQ synthesis protein D (PqqD) APS_kinase PF01583.20 CAV20071.1 - 2.8e-71 238.5 0.0 3.3e-71 238.3 0.0 1.1 1 0 0 1 1 1 1 Adenylylsulphate kinase AAA_33 PF13671.6 CAV20071.1 - 5.4e-10 39.6 0.0 7.5e-10 39.1 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 CAV20071.1 - 4.2e-06 27.3 0.0 6.6e-06 26.7 0.0 1.3 1 0 0 1 1 1 1 AAA domain CbiA PF01656.23 CAV20071.1 - 0.00021 21.4 0.0 0.00021 21.3 0.0 1.3 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_16 PF13191.6 CAV20071.1 - 0.0013 19.1 0.1 0.0017 18.7 0.1 1.5 1 1 0 1 1 1 1 AAA ATPase domain Torsin PF06309.11 CAV20071.1 - 0.0021 18.1 0.0 0.0033 17.5 0.0 1.3 1 0 0 1 1 1 1 Torsin SRP54 PF00448.22 CAV20071.1 - 0.0027 17.4 0.0 0.0037 16.9 0.0 1.3 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain AAA_29 PF13555.6 CAV20071.1 - 0.0047 16.6 0.0 0.0083 15.8 0.0 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain KTI12 PF08433.10 CAV20071.1 - 0.005 16.3 0.0 0.008 15.7 0.0 1.3 1 0 0 1 1 1 1 Chromatin associated protein KTI12 Zeta_toxin PF06414.12 CAV20071.1 - 0.0085 15.4 0.0 0.013 14.7 0.0 1.3 1 0 0 1 1 1 1 Zeta toxin ParA PF10609.9 CAV20071.1 - 0.0091 15.5 0.0 0.015 14.8 0.0 1.4 1 0 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase CPT PF07931.12 CAV20071.1 - 0.0091 15.9 0.1 0.13 12.1 0.1 2.1 1 1 0 1 1 1 1 Chloramphenicol phosphotransferase-like protein AAA_22 PF13401.6 CAV20071.1 - 0.013 15.7 0.0 0.025 14.9 0.0 1.5 2 0 0 2 2 1 0 AAA domain CLP1_P PF16575.5 CAV20071.1 - 0.016 15.0 0.0 0.026 14.3 0.0 1.3 1 0 0 1 1 1 0 mRNA cleavage and polyadenylation factor CLP1 P-loop Thymidylate_kin PF02223.17 CAV20071.1 - 0.039 13.6 0.0 0.066 12.9 0.0 1.3 1 0 0 1 1 1 0 Thymidylate kinase ABC_tran PF00005.27 CAV20071.1 - 0.057 13.9 0.0 0.057 13.9 0.0 1.3 1 1 0 1 1 1 0 ABC transporter PRK PF00485.18 CAV20071.1 - 0.08 12.7 0.0 0.12 12.1 0.0 1.3 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family MeaB PF03308.16 CAV20071.1 - 0.082 11.9 0.0 0.12 11.3 0.0 1.2 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB ArsA_ATPase PF02374.15 CAV20071.1 - 0.097 11.8 0.0 0.14 11.4 0.0 1.2 1 0 0 1 1 1 0 Anion-transporting ATPase AAA_17 PF13207.6 CAV20071.1 - 0.11 12.9 0.0 0.16 12.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 CAV20071.1 - 0.17 12.3 0.0 0.31 11.5 0.0 1.4 1 0 0 1 1 1 0 RNA helicase AAA_30 PF13604.6 CAV20071.1 - 0.17 11.5 0.0 0.22 11.2 0.0 1.2 1 0 0 1 1 1 0 AAA domain CitMHS PF03600.16 CAV20073.1 - 6.4e-32 110.9 0.5 9.5e-32 110.4 0.3 1.3 1 1 0 1 1 1 1 Citrate transporter TrkA_C PF02080.21 CAV20073.1 - 2.2e-26 91.4 2.0 6.3e-13 48.4 0.0 3.0 4 0 0 4 4 4 2 TrkA-C domain Na_sulph_symp PF00939.19 CAV20073.1 - 4e-09 36.0 28.3 6.5e-09 35.4 11.2 2.5 2 1 0 2 2 2 2 Sodium:sulfate symporter transmembrane region Frigida PF07899.11 CAV20073.1 - 0.17 11.1 0.1 0.29 10.3 0.1 1.3 1 0 0 1 1 1 0 Frigida-like protein GTP_EFTU PF00009.27 CAV20074.1 - 2.2e-45 154.6 0.0 4.1e-45 153.7 0.0 1.4 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 CAV20074.1 - 2.8e-07 30.6 0.0 6.5e-06 26.2 0.0 2.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU_D2 PF03144.25 CAV20074.1 - 0.00026 21.3 0.6 0.00065 20.0 0.1 1.9 2 0 0 2 2 2 1 Elongation factor Tu domain 2 FeoB_N PF02421.18 CAV20074.1 - 0.0089 15.6 0.0 0.56 9.7 0.1 3.2 3 1 0 3 3 3 1 Ferrous iron transport protein B Roc PF08477.13 CAV20074.1 - 0.0091 16.2 0.1 7.4 6.8 0.0 2.8 2 1 1 3 3 3 2 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 CAV20074.1 - 0.024 14.1 0.0 0.9 8.9 0.0 2.4 1 1 1 2 2 2 0 Signal recognition particle receptor beta subunit SRP54 PF00448.22 CAV20074.1 - 0.028 14.1 0.0 0.059 13.0 0.0 1.5 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain PAPS_reduct PF01507.19 CAV20075.1 - 3.1e-63 212.9 0.0 3.8e-63 212.7 0.0 1.1 1 0 0 1 1 1 1 Phosphoadenosine phosphosulfate reductase family 5_nucleotid_C PF02872.18 CAV20076.1 - 4.1e-19 69.3 0.1 8.5e-19 68.3 0.1 1.5 1 0 0 1 1 1 1 5'-nucleotidase, C-terminal domain Metallophos PF00149.28 CAV20076.1 - 7.5e-11 42.9 0.2 1.3e-10 42.2 0.2 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase DUF4649 PF15507.6 CAV20076.1 - 0.0067 16.4 0.1 2.7 8.0 0.0 2.6 2 0 0 2 2 2 2 Domain of unknown function (DUF4649) SNARE_assoc PF09335.11 CAV20077.1 - 5.8e-12 46.2 11.6 9.4e-12 45.5 11.6 1.4 1 0 0 1 1 1 1 SNARE associated Golgi protein RimK PF08443.11 CAV20078.1 - 0.0014 18.3 0.0 0.0027 17.4 0.0 1.4 1 0 0 1 1 1 1 RimK-like ATP-grasp domain Dala_Dala_lig_C PF07478.13 CAV20078.1 - 0.0046 16.5 0.0 0.01 15.4 0.0 1.5 2 0 0 2 2 2 1 D-ala D-ala ligase C-terminus ATP-grasp_4 PF13535.6 CAV20078.1 - 0.083 12.5 0.0 0.13 11.8 0.0 1.3 1 0 0 1 1 1 0 ATP-grasp domain CPSase_L_D2 PF02786.17 CAV20078.1 - 0.15 11.5 0.0 0.27 10.7 0.0 1.3 1 0 0 1 1 1 0 Carbamoyl-phosphate synthase L chain, ATP binding domain DinB_2 PF12867.7 CAV20080.1 - 0.13 12.7 2.2 0.3 11.6 2.2 1.6 1 1 0 1 1 1 0 DinB superfamily TANGO2 PF05742.12 CAV20081.1 - 3.1e-07 30.7 0.0 3.3e-07 30.6 0.0 1.2 1 0 0 1 1 1 1 Transport and Golgi organisation 2 YHS PF04945.13 CAV20082.1 - 2.2e-11 43.7 0.4 3.9e-11 42.9 0.4 1.4 1 0 0 1 1 1 1 YHS domain FAP206 PF12018.8 CAV20082.1 - 0.17 11.3 0.2 0.71 9.3 0.2 1.8 1 1 0 1 1 1 0 Domain of unknown function DoxX_2 PF13564.6 CAV20083.1 - 0.015 15.4 6.9 0.015 15.4 6.9 1.5 1 1 0 1 1 1 0 DoxX-like family Oxidored_q2 PF00420.24 CAV20083.1 - 0.058 13.0 1.0 0.12 12.0 1.0 1.5 1 0 0 1 1 1 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L Acetyltransf_5 PF13444.6 CAV20084.1 - 4.3e-19 69.1 0.0 9.1e-19 68.0 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acyltransferase PF01553.21 CAV20084.1 - 3.8e-07 29.8 0.0 6.4e-07 29.1 0.0 1.4 1 0 0 1 1 1 1 Acyltransferase cNMP_binding PF00027.29 CAV20086.1 - 3.9e-09 36.4 0.0 5.2e-09 36.1 0.0 1.2 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain HTH_Crp_2 PF13545.6 CAV20086.1 - 0.12 12.4 0.0 0.3 11.1 0.0 1.7 2 0 0 2 2 2 0 Crp-like helix-turn-helix domain Acetyltransf_10 PF13673.7 CAV20087.1 - 2.2e-15 56.7 0.0 2.4e-15 56.6 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 CAV20087.1 - 5e-09 36.5 0.0 7.2e-09 35.9 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 CAV20087.1 - 2.8e-06 27.6 0.0 3.5e-06 27.3 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_9 PF13527.7 CAV20087.1 - 0.0003 20.8 0.0 0.0004 20.5 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 CAV20087.1 - 0.042 13.8 0.0 0.064 13.2 0.0 1.4 1 1 0 1 1 1 0 FR47-like protein EamA PF00892.20 CAV20088.1 - 4.7e-24 85.1 31.9 8.6e-15 55.1 8.5 2.0 2 0 0 2 2 2 2 EamA-like transporter family DUF4905 PF16248.5 CAV20088.1 - 0.046 13.6 0.0 0.092 12.7 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4905) Multi_Drug_Res PF00893.19 CAV20088.1 - 0.42 11.3 12.9 1.6 9.5 3.9 3.0 1 1 0 2 2 2 0 Small Multidrug Resistance protein OapA PF04225.12 CAV20089.1 - 2.3e-38 130.1 0.1 3.9e-38 129.4 0.1 1.4 1 0 0 1 1 1 1 Opacity-associated protein A LysM-like domain OapA_N PF08525.11 CAV20089.1 - 1.5e-07 31.1 5.3 2.5e-07 30.5 5.3 1.3 1 0 0 1 1 1 1 Opacity-associated protein A N-terminal motif FKBP_C PF00254.28 CAV20092.1 - 7.6e-27 93.5 0.0 1.3e-26 92.7 0.0 1.3 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase FKBP_N PF01346.18 CAV20092.1 - 2.2e-22 79.8 0.3 2.9e-22 79.5 0.3 1.2 1 0 0 1 1 1 1 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase Phage_TAC_12 PF12363.8 CAV20092.1 - 0.043 14.2 0.1 0.071 13.5 0.1 1.4 1 0 0 1 1 1 0 Phage tail assembly chaperone protein, TAC DUF2780 PF11075.8 CAV20093.1 - 2.4e-21 76.7 10.7 4.2e-21 75.9 10.7 1.4 1 1 0 1 1 1 1 Protein of unknown function VcgC/VcgE (DUF2780) Ribosomal_L17 PF01196.19 CAV20096.1 - 1.1e-34 119.1 0.0 1.4e-34 118.9 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L17 RNA_pol_A_bac PF01000.26 CAV20097.1 - 2.1e-24 86.0 0.1 4.6e-24 84.9 0.1 1.6 1 1 0 1 1 1 1 RNA polymerase Rpb3/RpoA insert domain RNA_pol_A_CTD PF03118.15 CAV20097.1 - 4.2e-24 84.1 0.1 7.6e-24 83.3 0.1 1.4 1 0 0 1 1 1 1 Bacterial RNA polymerase, alpha chain C terminal domain RNA_pol_L PF01193.24 CAV20097.1 - 1.4e-23 82.0 0.0 2.7e-23 81.2 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain RNA_pol_L_2 PF13656.6 CAV20097.1 - 0.00088 19.0 0.0 1.1 9.1 0.0 2.6 2 0 0 2 2 2 2 RNA polymerase Rpb3/Rpb11 dimerisation domain TrkA_N PF02254.18 CAV20097.1 - 0.074 13.3 0.0 0.13 12.5 0.0 1.4 1 0 0 1 1 1 0 TrkA-N domain Ribosomal_S4 PF00163.19 CAV20098.1 - 2.7e-32 111.5 1.7 4.5e-32 110.8 1.7 1.3 1 0 0 1 1 1 1 Ribosomal protein S4/S9 N-terminal domain S4 PF01479.25 CAV20098.1 - 7.3e-17 60.8 0.3 1.3e-16 60.0 0.3 1.5 1 0 0 1 1 1 1 S4 domain E1_dh PF00676.20 CAV20098.1 - 0.0058 15.6 0.1 0.0082 15.1 0.1 1.2 1 0 0 1 1 1 1 Dehydrogenase E1 component S4_2 PF13275.6 CAV20098.1 - 0.03 14.1 0.1 0.064 13.1 0.1 1.5 1 0 0 1 1 1 0 S4 domain Ribosomal_S11 PF00411.19 CAV20099.1 - 9.7e-52 174.0 0.5 1.1e-51 173.8 0.5 1.1 1 0 0 1 1 1 1 Ribosomal protein S11 LppA PF16708.5 CAV20099.1 - 0.04 13.9 0.1 0.047 13.6 0.1 1.2 1 1 0 1 1 1 0 Lipoprotein confined to pathogenic Mycobacterium Ribosomal_S13 PF00416.22 CAV20100.1 - 6.3e-34 117.1 6.7 4.6e-32 111.1 6.7 2.0 1 1 0 1 1 1 1 Ribosomal protein S13/S18 FbpA PF05833.11 CAV20100.1 - 0.026 13.3 0.0 0.03 13.1 0.0 1.1 1 0 0 1 1 1 0 Fibronectin-binding protein A N-terminus (FbpA) Ribosomal_L36 PF00444.18 CAV20101.1 - 9.7e-19 67.3 12.3 1e-18 67.2 12.3 1.0 1 0 0 1 1 1 1 Ribosomal protein L36 SecY PF00344.20 CAV20102.1 - 1e-116 389.5 20.4 1.2e-116 389.3 20.4 1.1 1 0 0 1 1 1 1 SecY translocase DUF1772 PF08592.11 CAV20102.1 - 4.7 7.5 18.6 64 3.9 2.2 4.2 1 1 1 2 2 2 0 Domain of unknown function (DUF1772) Ribosomal_L27A PF00828.19 CAV20103.1 - 4.7e-32 111.4 3.7 6e-32 111.0 3.7 1.1 1 0 0 1 1 1 1 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A Ribosomal_L18 PF17135.4 CAV20103.1 - 0.071 12.5 0.9 0.11 11.9 0.8 1.5 1 1 0 1 1 1 0 Ribosomal protein 60S L18 and 50S L18e Ribosomal_L30 PF00327.20 CAV20104.1 - 8.8e-21 73.5 0.1 1e-20 73.3 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein L30p/L7e Ribosomal_S5 PF00333.20 CAV20105.1 - 7.3e-30 102.7 3.6 1.3e-29 101.9 3.6 1.4 1 0 0 1 1 1 1 Ribosomal protein S5, N-terminal domain Ribosomal_S5_C PF03719.15 CAV20105.1 - 4.2e-29 99.8 0.8 6.7e-29 99.2 0.8 1.3 1 0 0 1 1 1 1 Ribosomal protein S5, C-terminal domain Ribosomal_L18p PF00861.22 CAV20107.1 - 2.2e-42 144.1 7.9 2.5e-42 143.9 7.9 1.0 1 0 0 1 1 1 1 Ribosomal L18 of archaea, bacteria, mitoch. and chloroplast Ribosomal_L5e PF17144.4 CAV20107.1 - 0.00027 20.9 0.2 0.0003 20.8 0.2 1.1 1 0 0 1 1 1 1 Ribosomal large subunit proteins 60S L5, and 50S L18 TM1506 PF08973.10 CAV20107.1 - 0.0029 17.3 1.3 0.0038 16.9 0.3 1.7 1 1 1 2 2 2 1 Domain of unknown function (DUF1893) Ribosomal_L6 PF00347.23 CAV20108.1 - 8e-41 138.6 2.2 8.9e-20 71.2 1.1 2.1 2 0 0 2 2 2 2 Ribosomal protein L6 Ribosomal_S8 PF00410.19 CAV20109.1 - 1.8e-46 157.2 0.1 2e-46 157.1 0.1 1.0 1 0 0 1 1 1 1 Ribosomal protein S8 Ribosomal_S14 PF00253.21 CAV20110.1 - 1.4e-24 85.6 2.2 2.5e-24 84.8 2.2 1.4 1 0 0 1 1 1 1 Ribosomal protein S14p/S29e Ribosomal_L5_C PF00673.21 CAV20111.1 - 2.2e-41 139.9 0.0 3.4e-41 139.3 0.0 1.3 1 0 0 1 1 1 1 ribosomal L5P family C-terminus Ribosomal_L5 PF00281.19 CAV20111.1 - 1.5e-29 102.1 0.5 2.7e-29 101.3 0.5 1.4 1 0 0 1 1 1 1 Ribosomal protein L5 ribosomal_L24 PF17136.4 CAV20112.1 - 6.3e-24 84.2 1.9 8.5e-24 83.7 0.1 1.8 2 0 0 2 2 2 1 Ribosomal proteins 50S L24/mitochondrial 39S L24 KOW PF00467.29 CAV20112.1 - 7.2e-06 25.8 4.2 2.1e-05 24.3 4.2 1.9 1 0 0 1 1 1 1 KOW motif GTP_EFTU_D2 PF03144.25 CAV20112.1 - 0.025 15.0 1.3 0.025 15.0 1.3 1.7 2 1 0 2 2 2 0 Elongation factor Tu domain 2 Ribosomal_L14 PF00238.19 CAV20114.1 - 6.6e-40 136.0 0.4 7e-40 135.9 0.4 1.0 1 0 0 1 1 1 1 Ribosomal protein L14p/L23e Ribosomal_S17 PF00366.20 CAV20115.1 - 3e-33 113.7 1.1 3.5e-33 113.5 1.1 1.1 1 0 0 1 1 1 1 Ribosomal protein S17 Ribosomal_L29 PF00831.23 CAV20116.1 - 1.2e-24 86.0 6.3 1.3e-24 85.9 6.3 1.0 1 0 0 1 1 1 1 Ribosomal L29 protein MRP-L47 PF06984.13 CAV20116.1 - 0.00063 19.8 1.5 0.00088 19.4 1.5 1.2 1 0 0 1 1 1 1 Mitochondrial 39-S ribosomal protein L47 (MRP-L47) Ribosomal_L16 PF00252.18 CAV20117.1 - 1.1e-42 145.1 1.8 1.3e-42 145.0 1.8 1.0 1 0 0 1 1 1 1 Ribosomal protein L16p/L10e RTC_insert PF05189.13 CAV20117.1 - 0.013 16.0 0.0 0.022 15.2 0.0 1.4 1 0 0 1 1 1 0 RNA 3'-terminal phosphate cyclase (RTC), insert domain Ribosomal_S3_C PF00189.20 CAV20118.1 - 4.1e-41 139.4 1.6 8e-41 138.5 1.6 1.5 1 0 0 1 1 1 1 Ribosomal protein S3, C-terminal domain KH_2 PF07650.17 CAV20118.1 - 3.9e-19 68.3 2.4 7.2e-19 67.4 2.4 1.5 1 0 0 1 1 1 1 KH domain KH_4 PF13083.6 CAV20118.1 - 0.0025 17.6 0.1 0.0063 16.4 0.1 1.6 1 1 0 1 1 1 1 KH domain AP_endonuc_2 PF01261.24 CAV20118.1 - 0.066 12.6 0.1 0.09 12.2 0.1 1.3 1 0 0 1 1 1 0 Xylose isomerase-like TIM barrel Ribosomal_L22 PF00237.19 CAV20120.1 - 1.8e-35 121.3 1.0 2e-35 121.1 1.0 1.0 1 0 0 1 1 1 1 Ribosomal protein L22p/L17e YqeY PF09424.10 CAV20120.1 - 0.039 14.0 0.7 3 7.9 0.0 2.2 1 1 1 2 2 2 0 Yqey-like protein Ribosomal_S19 PF00203.21 CAV20121.1 - 4.1e-37 125.9 0.2 4.7e-37 125.7 0.2 1.0 1 0 0 1 1 1 1 Ribosomal protein S19 Ribosomal_L2_C PF03947.18 CAV20122.1 - 1.8e-56 189.8 3.6 2.8e-56 189.1 3.6 1.3 1 0 0 1 1 1 1 Ribosomal Proteins L2, C-terminal domain Ribosomal_L2 PF00181.23 CAV20122.1 - 9.4e-33 112.0 2.4 1.4e-32 111.4 1.3 1.9 2 0 0 2 2 2 1 Ribosomal Proteins L2, RNA binding domain Ribosomal_L23 PF00276.20 CAV20123.1 - 7.6e-32 109.5 5.1 8.9e-32 109.3 5.1 1.0 1 0 0 1 1 1 1 Ribosomal protein L23 ubiquitin PF00240.23 CAV20123.1 - 0.0025 17.5 0.2 0.0041 16.9 0.2 1.3 1 0 0 1 1 1 1 Ubiquitin family Ribosomal_L4 PF00573.22 CAV20124.1 - 1.9e-65 220.2 0.8 2.1e-65 220.0 0.8 1.0 1 0 0 1 1 1 1 Ribosomal protein L4/L1 family DUF3556 PF12077.8 CAV20124.1 - 0.095 11.1 0.0 0.096 11.1 0.0 1.1 1 0 0 1 1 1 0 Transmembrane protein of unknown function (DUF3556) Ribosomal_L3 PF00297.22 CAV20125.1 - 1.2e-15 57.4 1.9 1.2e-15 57.4 1.9 2.5 1 1 2 3 3 3 2 Ribosomal protein L3 Ribosomal_S10 PF00338.22 CAV20126.1 - 3.3e-33 113.8 0.1 3.7e-33 113.6 0.1 1.0 1 0 0 1 1 1 1 Ribosomal protein S10p/S20e GTP_EFTU PF00009.27 CAV20127.1 - 4.9e-58 195.9 0.0 6.5e-58 195.5 0.0 1.1 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 CAV20127.1 - 1.7e-33 115.3 0.0 3.5e-33 114.3 0.0 1.6 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 CAV20127.1 - 2.5e-17 63.0 4.6 6.6e-17 61.7 4.6 1.8 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 CAV20127.1 - 0.00019 21.5 0.0 0.00032 20.7 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase cobW PF02492.19 CAV20127.1 - 0.1 12.2 0.0 0.35 10.4 0.0 1.8 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain GTP_EFTU PF00009.27 CAV20128.1 - 1.7e-66 223.5 0.2 2.9e-66 222.7 0.2 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_IV PF03764.18 CAV20128.1 - 1.4e-45 154.0 0.1 3.5e-45 152.7 0.1 1.8 1 0 0 1 1 1 1 Elongation factor G, domain IV EFG_II PF14492.6 CAV20128.1 - 3.1e-32 110.5 0.0 7e-32 109.3 0.0 1.7 1 0 0 1 1 1 1 Elongation Factor G, domain II EFG_C PF00679.24 CAV20128.1 - 1.3e-31 108.5 0.0 4.6e-31 106.7 0.0 2.0 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 CAV20128.1 - 4.3e-16 59.1 1.1 1.3e-15 57.5 1.1 1.9 1 0 0 1 1 1 1 Elongation factor Tu domain 2 RF3_C PF16658.5 CAV20128.1 - 2.5e-05 24.1 0.0 8.1e-05 22.5 0.0 1.8 1 0 0 1 1 1 1 Class II release factor RF3, C-terminal domain MMR_HSR1 PF01926.23 CAV20128.1 - 0.0014 18.7 0.0 0.0042 17.2 0.0 1.8 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU_D4 PF14578.6 CAV20128.1 - 0.0067 16.3 0.1 0.019 14.8 0.1 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 4 Ribosomal_S7 PF00177.21 CAV20129.1 - 3.5e-65 218.2 5.7 3.9e-65 218.1 5.7 1.0 1 0 0 1 1 1 1 Ribosomal protein S7p/S5e ATC_hydrolase PF14196.6 CAV20129.1 - 1.1 10.1 4.2 18 6.1 1.1 2.0 1 1 1 2 2 2 0 L-2-amino-thiazoline-4-carboxylic acid hydrolase Ribosom_S12_S23 PF00164.25 CAV20130.1 - 3.4e-42 142.7 1.4 3.9e-42 142.5 1.4 1.0 1 0 0 1 1 1 1 Ribosomal protein S12/S23 Ribosomal_S12 PF17487.2 CAV20130.1 - 0.11 13.2 0.0 0.2 12.4 0.0 1.4 1 1 0 1 1 1 0 Ribosomal protein S12 DsrH PF04077.12 CAV20131.1 - 4.6e-20 71.5 0.7 5.4e-20 71.3 0.7 1.0 1 0 0 1 1 1 1 DsrH like protein RPW8 PF05659.11 CAV20131.1 - 0.076 12.7 0.1 0.094 12.4 0.1 1.3 1 1 0 1 1 1 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 DrsE PF02635.15 CAV20132.1 - 2.9e-26 92.1 0.1 3.2e-26 92.0 0.1 1.0 1 0 0 1 1 1 1 DsrE/DsrF-like family GUN4 PF05419.12 CAV20132.1 - 0.13 12.3 0.0 0.15 12.1 0.0 1.2 1 0 0 1 1 1 0 GUN4-like DrsE PF02635.15 CAV20133.1 - 2.1e-25 89.4 0.1 2.4e-25 89.2 0.1 1.0 1 0 0 1 1 1 1 DsrE/DsrF-like family SRR1 PF07985.12 CAV20133.1 - 0.21 11.7 0.9 34 4.6 0.0 3.1 3 0 0 3 3 3 0 SRR1 PAS_6 PF08348.11 CAV20134.1 - 6.8e-36 122.6 0.0 1.3e-35 121.7 0.0 1.4 1 0 0 1 1 1 1 YheO-like PAS domain HTH_22 PF13309.6 CAV20134.1 - 5.3e-19 68.0 0.4 9.5e-19 67.2 0.4 1.4 1 0 0 1 1 1 1 HTH domain DUF658 PF04936.12 CAV20134.1 - 0.00036 20.3 0.2 0.00069 19.4 0.2 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF658) HTH_23 PF13384.6 CAV20134.1 - 0.00063 19.5 0.0 0.0014 18.3 0.0 1.7 1 0 0 1 1 1 1 Homeodomain-like domain HTH_7 PF02796.15 CAV20134.1 - 0.0021 18.1 0.2 0.0068 16.5 0.2 2.0 1 1 0 1 1 1 1 Helix-turn-helix domain of resolvase dCache_1 PF02743.18 CAV20134.1 - 0.0072 16.1 0.2 0.018 14.9 0.0 1.8 2 0 0 2 2 2 1 Cache domain HTH_17 PF12728.7 CAV20134.1 - 0.013 15.7 0.1 0.028 14.6 0.1 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_10 PF04967.12 CAV20134.1 - 0.053 13.3 0.0 0.13 12.1 0.0 1.6 1 0 0 1 1 1 0 HTH DNA binding domain NeuB PF03102.14 CAV20134.1 - 0.091 12.2 0.0 0.14 11.6 0.0 1.3 1 0 0 1 1 1 0 NeuB family HTH_28 PF13518.6 CAV20134.1 - 0.16 12.1 0.0 0.28 11.4 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain FKBP_C PF00254.28 CAV20135.1 - 3.8e-31 107.3 0.0 1.2e-30 105.7 0.0 1.8 2 0 0 2 2 2 1 FKBP-type peptidyl-prolyl cis-trans isomerase FKBP_N PF01346.18 CAV20135.1 - 3.7e-23 82.3 2.7 6.6e-23 81.5 2.7 1.4 1 0 0 1 1 1 1 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase CCDC50_N PF15295.6 CAV20135.1 - 6.3e-05 23.1 2.0 9.4e-05 22.6 2.0 1.2 1 0 0 1 1 1 1 Coiled-coil domain-containing protein 50 N-terminus DUF1840 PF08895.11 CAV20135.1 - 0.083 13.2 1.1 0.18 12.1 1.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1840) WD40 PF00400.32 CAV20136.1 - 2.4e-11 44.0 0.1 0.0064 17.3 0.0 5.9 7 0 0 7 7 7 3 WD domain, G-beta repeat PQQ_2 PF13360.6 CAV20136.1 - 4.4e-07 29.7 6.4 0.00054 19.6 0.8 2.2 1 1 1 2 2 2 2 PQQ-like domain ANAPC4_WD40 PF12894.7 CAV20136.1 - 1.1e-05 25.7 0.4 6 7.2 0.0 4.6 1 1 4 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain B_lectin PF01453.24 CAV20136.1 - 0.0023 18.4 0.8 3.7 8.1 0.0 3.3 2 2 2 4 4 4 3 D-mannose binding lectin SlyX PF04102.12 CAV20137.1 - 5.3e-24 84.6 1.1 6.2e-24 84.4 0.6 1.3 1 1 1 2 2 2 1 SlyX DUF16 PF01519.16 CAV20137.1 - 0.0032 17.9 4.1 0.0037 17.7 4.1 1.0 1 0 0 1 1 1 1 Protein of unknown function DUF16 MscS_porin PF12795.7 CAV20137.1 - 0.0034 17.0 3.1 0.0034 17.0 3.1 1.1 1 0 0 1 1 1 1 Mechanosensitive ion channel porin domain DUF1664 PF07889.12 CAV20137.1 - 0.0034 17.4 1.8 0.0042 17.1 1.8 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1664) XhlA PF10779.9 CAV20137.1 - 0.0042 17.3 0.7 0.0061 16.7 0.5 1.5 1 1 0 1 1 1 1 Haemolysin XhlA FlaC_arch PF05377.11 CAV20137.1 - 0.0099 16.3 2.3 0.03 14.7 1.1 1.9 1 1 1 2 2 2 1 Flagella accessory protein C (FlaC) HrpB7 PF09486.10 CAV20137.1 - 0.01 16.3 1.1 0.011 16.1 1.1 1.0 1 0 0 1 1 1 1 Bacterial type III secretion protein (HrpB7) MPS2 PF17060.5 CAV20137.1 - 0.012 14.9 1.2 0.014 14.6 1.2 1.2 1 0 0 1 1 1 0 Monopolar spindle protein 2 Prefoldin_2 PF01920.20 CAV20137.1 - 0.012 15.5 4.5 0.014 15.4 3.2 1.7 1 1 1 2 2 2 0 Prefoldin subunit ADIP PF11559.8 CAV20137.1 - 0.015 15.4 1.5 0.016 15.3 1.5 1.1 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding PKcGMP_CC PF16808.5 CAV20137.1 - 0.015 15.1 0.4 0.025 14.4 0.4 1.5 1 1 0 1 1 1 0 Coiled-coil N-terminus of cGMP-dependent protein kinase PspA_IM30 PF04012.12 CAV20137.1 - 0.017 14.7 3.0 0.02 14.5 3.0 1.1 1 0 0 1 1 1 0 PspA/IM30 family DUF4988 PF16378.5 CAV20137.1 - 0.029 14.1 0.6 0.03 14.0 0.6 1.1 1 0 0 1 1 1 0 Domain of unknown function NPV_P10 PF05531.12 CAV20137.1 - 0.036 14.5 0.8 0.046 14.2 0.8 1.3 1 0 0 1 1 1 0 Nucleopolyhedrovirus P10 protein DUF3552 PF12072.8 CAV20137.1 - 0.038 13.4 2.1 0.04 13.3 2.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF3552) Mt_ATP-synt_D PF05873.12 CAV20137.1 - 0.042 13.7 0.3 0.055 13.3 0.3 1.3 1 1 0 1 1 1 0 ATP synthase D chain, mitochondrial (ATP5H) ORF6C PF10552.9 CAV20137.1 - 0.046 13.8 0.8 0.056 13.5 0.8 1.3 1 0 0 1 1 1 0 ORF6C domain JAKMIP_CC3 PF16034.5 CAV20137.1 - 0.05 13.6 3.6 0.053 13.5 3.6 1.0 1 0 0 1 1 1 0 JAKMIP CC3 domain Spc29 PF17082.5 CAV20137.1 - 0.059 13.2 1.4 0.062 13.1 1.4 1.1 1 0 0 1 1 1 0 Spindle Pole Component 29 Tropomyosin_1 PF12718.7 CAV20137.1 - 0.067 13.4 2.9 0.067 13.3 2.9 1.1 1 0 0 1 1 1 0 Tropomyosin like BST2 PF16716.5 CAV20137.1 - 0.074 13.6 3.7 0.097 13.3 3.7 1.2 1 0 0 1 1 1 0 Bone marrow stromal antigen 2 UPF0242 PF06785.11 CAV20137.1 - 0.088 12.9 5.2 0.56 10.3 5.2 1.9 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus DUF641 PF04859.12 CAV20137.1 - 0.089 13.1 1.6 0.097 13.0 1.6 1.2 1 0 0 1 1 1 0 Plant protein of unknown function (DUF641) DUF536 PF04394.14 CAV20137.1 - 0.1 12.5 7.5 0.058 13.2 5.3 1.7 2 0 0 2 2 2 0 Protein of unknown function, DUF536 DUF4806 PF16064.5 CAV20137.1 - 0.37 11.1 3.0 0.95 9.8 0.3 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4806) TRPM_tetra PF16519.5 CAV20137.1 - 0.38 10.9 6.6 0.53 10.4 6.6 1.3 1 0 0 1 1 1 0 Tetramerisation domain of TRPM TolA_bind_tri PF16331.5 CAV20137.1 - 1.3 9.1 9.9 5.2 7.2 4.7 2.1 1 1 1 2 2 2 0 TolA binding protein trimerisation Asparaginase_2 PF01112.18 CAV20138.1 - 1.2e-107 359.5 8.7 1.3e-107 359.3 8.7 1.0 1 0 0 1 1 1 1 Asparaginase G_glu_transpept PF01019.21 CAV20138.1 - 0.022 13.5 0.3 1.9 7.1 0.1 2.1 2 0 0 2 2 2 0 Gamma-glutamyltranspeptidase FKBP_C PF00254.28 CAV20139.1 - 7e-13 48.7 0.2 1e-12 48.2 0.2 1.3 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase UreE_C PF05194.12 CAV20139.1 - 0.15 12.6 5.9 0.38 11.3 5.9 1.7 1 0 0 1 1 1 0 UreE urease accessory protein, C-terminal domain HlyD PF00529.20 CAV20139.1 - 5.5 6.9 5.2 14 5.6 5.2 2.0 1 1 0 1 1 1 0 HlyD membrane-fusion protein of T1SS DUF2387 PF09526.10 CAV20140.1 - 6.1e-21 74.4 0.8 7.1e-21 74.1 0.8 1.1 1 0 0 1 1 1 1 Probable metal-binding protein (DUF2387) GATA PF00320.27 CAV20140.1 - 0.012 15.2 1.8 0.017 14.7 1.8 1.2 1 0 0 1 1 1 0 GATA zinc finger Lar_restr_allev PF14354.6 CAV20140.1 - 0.018 15.4 0.4 0.027 14.9 0.4 1.2 1 0 0 1 1 1 0 Restriction alleviation protein Lar eIF-5_eIF-2B PF01873.17 CAV20140.1 - 0.028 14.3 0.3 0.039 13.8 0.3 1.2 1 0 0 1 1 1 0 Domain found in IF2B/IF5 zinc_ribbon_13 PF09855.9 CAV20140.1 - 0.04 14.1 0.4 0.35 11.1 0.0 2.0 2 0 0 2 2 2 0 Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082) OrfB_Zn_ribbon PF07282.11 CAV20140.1 - 0.077 12.9 0.4 0.11 12.4 0.4 1.2 1 0 0 1 1 1 0 Putative transposase DNA-binding domain Rubredoxin_2 PF18073.1 CAV20140.1 - 0.085 12.6 3.7 3.6 7.4 0.3 2.2 2 0 0 2 2 2 0 Rubredoxin metal binding domain Na_H_Exchanger PF00999.21 CAV20141.1 - 2.8e-65 220.6 52.8 3.7e-65 220.2 52.8 1.1 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family TrkA_N PF02254.18 CAV20141.1 - 1.9e-21 76.5 0.0 3.9e-21 75.5 0.0 1.5 1 0 0 1 1 1 1 TrkA-N domain Gp_dh_N PF00044.24 CAV20141.1 - 0.14 12.6 0.0 0.23 11.8 0.0 1.4 1 0 0 1 1 1 0 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain Tetraspanin PF00335.20 CAV20141.1 - 0.96 9.1 9.8 1.3 8.7 7.6 2.3 2 0 0 2 2 2 0 Tetraspanin family Flavodoxin_2 PF02525.17 CAV20142.1 - 3e-40 138.1 0.1 3.5e-40 137.8 0.1 1.0 1 0 0 1 1 1 1 Flavodoxin-like fold FMN_red PF03358.15 CAV20142.1 - 0.0051 16.6 0.0 0.0079 16.0 0.0 1.5 1 0 0 1 1 1 1 NADPH-dependent FMN reductase ABC_tran PF00005.27 CAV20143.1 - 3.1e-48 163.8 4.8 7.1e-25 88.1 0.0 3.1 4 0 0 4 4 2 2 ABC transporter ABC_tran_Xtn PF12848.7 CAV20143.1 - 2.1e-26 91.8 7.0 2.1e-26 91.8 7.0 3.5 2 1 0 2 2 2 1 ABC transporter AAA_21 PF13304.6 CAV20143.1 - 3.7e-13 49.9 8.8 0.014 15.2 0.0 4.4 3 1 1 4 4 4 4 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 CAV20143.1 - 5.6e-08 32.5 6.6 0.031 13.7 0.0 4.9 4 2 1 5 5 5 2 RecF/RecN/SMC N terminal domain KAP_NTPase PF07693.14 CAV20143.1 - 1.1e-06 28.1 0.0 0.073 12.3 0.6 2.9 2 2 0 2 2 2 2 KAP family P-loop domain MMR_HSR1 PF01926.23 CAV20143.1 - 1.3e-06 28.4 0.1 0.018 15.1 0.0 3.2 2 1 0 2 2 2 2 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 CAV20143.1 - 4.4e-06 26.7 4.2 0.002 18.1 0.1 3.0 3 0 0 3 3 3 2 RsgA GTPase AAA_29 PF13555.6 CAV20143.1 - 5.4e-06 26.1 1.2 0.074 12.8 0.1 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_18 PF13238.6 CAV20143.1 - 6e-06 26.8 0.3 0.1 13.1 0.0 3.3 3 0 0 3 3 3 2 AAA domain AAA_16 PF13191.6 CAV20143.1 - 1.8e-05 25.2 3.7 0.035 14.5 0.0 3.1 2 2 1 3 3 3 2 AAA ATPase domain MeaB PF03308.16 CAV20143.1 - 3.1e-05 23.1 4.1 0.014 14.4 0.0 3.4 3 0 0 3 3 3 2 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_23 PF13476.6 CAV20143.1 - 0.00023 21.7 21.7 0.073 13.6 0.0 4.4 4 0 0 4 4 4 2 AAA domain AAA_22 PF13401.6 CAV20143.1 - 0.00047 20.5 1.8 5.3 7.3 0.0 4.3 4 0 0 4 4 4 0 AAA domain AAA PF00004.29 CAV20143.1 - 0.00059 20.3 0.0 2.3 8.7 0.0 3.0 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) NB-ARC PF00931.22 CAV20143.1 - 0.00073 18.8 0.0 0.28 10.3 0.0 2.8 2 0 0 2 2 2 1 NB-ARC domain Zeta_toxin PF06414.12 CAV20143.1 - 0.0014 18.0 0.5 1.8 7.8 0.2 2.6 2 0 0 2 2 2 2 Zeta toxin RNA_helicase PF00910.22 CAV20143.1 - 0.0018 18.6 2.0 2.2 8.7 0.1 3.1 3 0 0 3 3 2 2 RNA helicase NTPase_1 PF03266.15 CAV20143.1 - 0.0024 17.8 0.4 0.81 9.6 0.1 2.6 2 0 0 2 2 2 1 NTPase NACHT PF05729.12 CAV20143.1 - 0.0048 16.8 6.1 1.7 8.5 0.1 3.7 4 0 0 4 4 3 2 NACHT domain AAA_30 PF13604.6 CAV20143.1 - 0.0049 16.6 0.0 1 9.1 0.0 3.4 3 0 0 3 3 3 1 AAA domain AAA_33 PF13671.6 CAV20143.1 - 0.0062 16.7 0.3 13 5.9 0.0 3.6 3 0 0 3 3 3 0 AAA domain ABC_tran_CTD PF16326.5 CAV20143.1 - 0.0065 16.7 12.8 0.0065 16.7 12.8 4.7 3 2 2 5 5 5 1 ABC transporter C-terminal domain DUF815 PF05673.13 CAV20143.1 - 0.0092 15.2 0.2 0.68 9.0 0.1 2.5 2 0 0 2 2 2 1 Protein of unknown function (DUF815) G-alpha PF00503.20 CAV20143.1 - 0.01 15.0 1.9 2.2 7.4 0.1 3.4 3 1 0 3 3 3 0 G-protein alpha subunit PduV-EutP PF10662.9 CAV20143.1 - 0.012 15.3 1.0 5.4 6.8 0.1 2.7 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Spore_SspJ PF09575.10 CAV20143.1 - 0.016 15.6 1.9 0.051 14.0 1.9 1.9 1 0 0 1 1 1 0 Small spore protein J (Spore_SspJ) Rad17 PF03215.15 CAV20143.1 - 0.017 15.0 0.4 8.8 6.2 0.0 3.3 3 0 0 3 3 3 0 Rad17 P-loop domain AAA_28 PF13521.6 CAV20143.1 - 0.019 15.2 0.1 4.2 7.6 0.0 3.1 2 0 0 2 2 2 0 AAA domain AAA_15 PF13175.6 CAV20143.1 - 0.04 13.6 12.2 0.59 9.8 0.0 4.1 3 1 0 3 3 3 0 AAA ATPase domain AAA_24 PF13479.6 CAV20143.1 - 0.048 13.4 2.7 5.4 6.7 0.0 3.1 4 0 0 4 4 2 0 AAA domain MobB PF03205.14 CAV20143.1 - 0.063 13.2 0.4 2.4 8.0 0.1 2.7 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B FeoB_N PF02421.18 CAV20143.1 - 0.09 12.3 0.1 8.9 5.8 0.0 2.6 2 0 0 2 2 2 0 Ferrous iron transport protein B ATP-synt_ab PF00006.25 CAV20143.1 - 0.1 12.2 0.0 8.7 5.9 0.0 2.3 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain TsaE PF02367.17 CAV20143.1 - 0.11 12.4 0.2 19 5.3 0.1 2.8 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Roc PF08477.13 CAV20143.1 - 0.12 12.7 0.8 20 5.4 0.0 2.8 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_5 PF07728.14 CAV20143.1 - 0.12 12.4 0.8 20 5.2 0.0 2.6 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) DUF87 PF01935.17 CAV20143.1 - 0.36 10.9 0.0 0.36 10.9 0.0 3.7 4 0 0 4 4 4 0 Helicase HerA, central domain AAA_13 PF13166.6 CAV20143.1 - 1 7.9 18.7 2.4 6.7 0.1 4.0 4 0 0 4 4 4 0 AAA domain Exonuc_VII_L PF02601.15 CAV20143.1 - 5 6.6 9.9 10 5.6 0.2 2.2 2 0 0 2 2 2 0 Exonuclease VII, large subunit DUF2390 PF09523.10 CAV20144.1 - 3.9e-28 97.9 8.2 5.3e-28 97.5 8.2 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2390) Cas_Csn2 PF09711.10 CAV20144.1 - 0.034 13.8 0.5 0.042 13.5 0.5 1.2 1 0 0 1 1 1 0 CRISPR-associated protein (Cas_Csn2) Abhydrolase_1 PF00561.20 CAV20145.1 - 4.1e-17 62.7 0.0 7.3e-17 61.8 0.0 1.4 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 CAV20145.1 - 9.6e-15 54.5 0.0 1.4e-14 54.0 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 UPF0270 PF06794.12 CAV20146.1 - 6.1e-33 112.7 0.4 6.6e-33 112.6 0.4 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0270) DUF4097 PF13349.6 CAV20146.1 - 0.031 13.6 0.0 0.035 13.4 0.0 1.0 1 0 0 1 1 1 0 Putative adhesin Hanta_nucleocap PF00846.18 CAV20146.1 - 0.04 12.4 0.0 0.042 12.3 0.0 1.0 1 0 0 1 1 1 0 Hantavirus nucleocapsid protein PRK PF00485.18 CAV20147.1 - 9.6e-71 237.6 0.0 1.1e-70 237.4 0.0 1.1 1 0 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family AAA_18 PF13238.6 CAV20147.1 - 0.061 13.9 0.0 0.12 12.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain APS_kinase PF01583.20 CAV20147.1 - 0.071 13.0 0.0 0.11 12.4 0.0 1.3 1 0 0 1 1 1 0 Adenylylsulphate kinase cNMP_binding PF00027.29 CAV20148.1 - 4.2e-23 81.2 0.0 7e-23 80.5 0.0 1.4 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain HTH_Crp_2 PF13545.6 CAV20148.1 - 5.6e-14 51.9 0.1 2.5e-13 49.8 0.0 1.9 2 0 0 2 2 2 1 Crp-like helix-turn-helix domain Crp PF00325.20 CAV20148.1 - 5.6e-10 38.7 0.1 1.2e-09 37.6 0.1 1.6 1 0 0 1 1 1 1 Bacterial regulatory proteins, crp family MarR_2 PF12802.7 CAV20148.1 - 0.0002 21.2 0.1 0.00077 19.3 0.0 1.9 2 0 0 2 2 2 1 MarR family HTH_23 PF13384.6 CAV20148.1 - 0.0003 20.5 0.0 0.00064 19.4 0.0 1.6 1 0 0 1 1 1 1 Homeodomain-like domain HTH_36 PF13730.6 CAV20148.1 - 0.0011 18.9 0.0 0.0043 17.0 0.1 2.0 2 0 0 2 2 2 1 Helix-turn-helix domain RepL PF05732.11 CAV20148.1 - 0.0028 17.1 0.1 0.15 11.4 0.1 2.3 2 0 0 2 2 2 1 Firmicute plasmid replication protein (RepL) HTH_24 PF13412.6 CAV20148.1 - 0.0061 16.1 0.3 0.017 14.7 0.3 1.8 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding MarR PF01047.22 CAV20148.1 - 0.008 16.1 0.2 0.034 14.1 0.1 2.0 2 0 0 2 2 2 1 MarR family Sigma70_r4 PF04545.16 CAV20148.1 - 0.027 14.0 0.2 0.057 12.9 0.2 1.5 1 0 0 1 1 1 0 Sigma-70, region 4 Rrf2 PF02082.20 CAV20148.1 - 0.044 14.1 0.2 0.5 10.7 0.0 2.3 2 0 0 2 2 2 0 Transcriptional regulator HTH_11 PF08279.12 CAV20148.1 - 0.045 13.7 0.3 0.11 12.5 0.1 1.8 2 0 0 2 2 2 0 HTH domain HhH-GPD PF00730.25 CAV20148.1 - 0.076 13.5 0.0 0.12 12.8 0.0 1.4 1 0 0 1 1 1 0 HhH-GPD superfamily base excision DNA repair protein DUF977 PF06163.11 CAV20148.1 - 0.093 12.7 0.3 7.1 6.6 0.2 2.4 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF977) SgrR_N PF12793.7 CAV20148.1 - 0.097 12.9 0.0 0.33 11.2 0.0 1.8 1 1 1 2 2 2 0 Sugar transport-related sRNA regulator N-term HTH_7 PF02796.15 CAV20148.1 - 0.099 12.7 0.1 0.21 11.7 0.1 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain of resolvase HTH_38 PF13936.6 CAV20148.1 - 0.14 11.9 0.0 0.47 10.2 0.0 1.9 1 0 0 1 1 1 0 Helix-turn-helix domain Sugarporin_N PF11471.8 CAV20149.1 - 0.0043 17.0 2.1 0.0076 16.2 2.1 1.4 1 0 0 1 1 1 1 Maltoporin periplasmic N-terminal extension HTH_Tnp_1 PF01527.20 CAV20149.1 - 0.081 13.3 3.1 0.3 11.4 3.1 1.9 1 1 0 1 1 1 0 Transposase rve PF00665.26 CAV20150.1 - 1.8e-26 92.6 0.1 6.2e-26 90.9 0.0 1.8 2 0 0 2 2 2 1 Integrase core domain rve_3 PF13683.6 CAV20150.1 - 2.6e-19 68.8 0.0 5.3e-19 67.8 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain DDE_Tnp_IS240 PF13610.6 CAV20150.1 - 0.0001 22.5 0.2 0.00018 21.7 0.2 1.4 1 0 0 1 1 1 1 DDE domain HTH_21 PF13276.6 CAV20150.1 - 0.015 15.4 1.6 0.043 14.0 1.0 2.1 2 0 0 2 2 2 0 HTH-like domain rve_2 PF13333.6 CAV20150.1 - 0.051 13.7 0.1 0.1 12.8 0.1 1.5 1 0 0 1 1 1 0 Integrase core domain RlmM_FDX PF18125.1 CAV20150.1 - 0.13 12.8 0.0 0.47 11.0 0.0 1.9 1 0 0 1 1 1 0 RlmM ferredoxin-like domain DUF1338 PF07063.13 CAV20151.1 - 5e-50 170.5 0.0 1e-47 163.0 0.0 2.2 1 1 0 1 1 1 1 Domain of unknown function (DUF1338) Aldedh PF00171.22 CAV20152.1 - 5.6e-120 401.0 0.1 6.8e-120 400.7 0.1 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Phage_TAC_13 PF16459.5 CAV20152.1 - 0.011 16.1 0.1 0.025 15.0 0.1 1.6 1 0 0 1 1 1 0 Phage tail assembly chaperone, TAC AstA PF04958.12 CAV20153.1 - 4.7e-138 459.4 0.0 5.3e-138 459.2 0.0 1.0 1 0 0 1 1 1 1 Arginine N-succinyltransferase beta subunit Aminotran_3 PF00202.21 CAV20154.1 - 2.7e-128 428.1 0.1 3.4e-128 427.8 0.1 1.0 1 0 0 1 1 1 1 Aminotransferase class-III Aminotran_1_2 PF00155.21 CAV20154.1 - 2.8e-05 23.5 0.0 4.3e-05 22.9 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.21 CAV20154.1 - 3.1e-05 23.4 0.0 6.2e-05 22.4 0.0 1.4 1 1 0 1 1 1 1 Beta-eliminating lyase Aminotran_5 PF00266.19 CAV20154.1 - 0.0048 15.9 0.0 0.0079 15.2 0.0 1.4 1 0 0 1 1 1 1 Aminotransferase class-V GATase PF00117.28 CAV20155.1 - 3.4e-54 183.5 0.0 3.9e-54 183.3 0.0 1.0 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.13 CAV20155.1 - 3.2e-09 36.9 0.1 5.7e-09 36.1 0.1 1.4 1 1 0 1 1 1 1 Peptidase C26 EAL PF00563.20 CAV20156.1 - 3.3e-64 216.7 0.0 6.2e-64 215.8 0.0 1.5 1 0 0 1 1 1 1 EAL domain dCache_2 PF08269.11 CAV20156.1 - 4.7e-61 206.6 7.8 7e-61 206.0 7.8 1.3 1 0 0 1 1 1 1 Cache domain GGDEF PF00990.21 CAV20156.1 - 1.8e-40 138.3 0.0 3.1e-40 137.6 0.0 1.4 1 0 0 1 1 1 1 Diguanylate cyclase, GGDEF domain sCache_2 PF17200.4 CAV20156.1 - 2.1e-36 125.1 0.4 1.3e-28 99.8 0.1 2.4 1 1 1 2 2 2 2 Single Cache domain 2 Cache_3-Cache_2 PF17201.4 CAV20156.1 - 3.9e-14 52.6 1.0 1.3e-07 31.2 0.1 2.4 1 1 1 2 2 2 2 Cache 3/Cache 2 fusion domain dCache_1 PF02743.18 CAV20156.1 - 1.7e-05 24.8 5.7 1.7e-05 24.8 5.7 2.2 2 1 0 2 2 2 1 Cache domain LydB PF16084.5 CAV20156.1 - 0.033 14.0 0.0 0.077 12.8 0.0 1.6 1 0 0 1 1 1 0 LydA-holin antagonist Phage_GP20 PF06810.11 CAV20156.1 - 0.096 12.5 1.0 1.2 9.0 0.5 2.5 2 0 0 2 2 2 0 Phage minor structural protein GP20 Neurensin PF14927.6 CAV20156.1 - 0.13 12.0 0.0 0.26 11.0 0.0 1.4 1 0 0 1 1 1 0 Neurensin LTD PF00932.19 CAV20157.1 - 5.9e-16 58.8 3.4 1.2e-15 57.8 1.4 2.4 2 0 0 2 2 2 1 Lamin Tail Domain tRNA_anti-codon PF01336.25 CAV20157.1 - 0.053 13.5 0.1 0.23 11.5 0.0 2.1 2 0 0 2 2 2 0 OB-fold nucleic acid binding domain Amidase_6 PF12671.7 CAV20157.1 - 0.066 13.3 0.1 3 7.9 0.0 2.6 2 0 0 2 2 2 0 Putative amidase domain VPDSG-CTERM PF18205.1 CAV20157.1 - 0.23 11.3 0.9 0.6 10.0 0.9 1.7 1 0 0 1 1 1 0 VPDSG-CTERM motif tRNA-synt_1b PF00579.25 CAV20159.1 - 1.3e-75 254.4 0.0 1.5e-75 254.2 0.0 1.0 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) Sec20 PF03908.13 CAV20159.1 - 0.11 12.4 0.3 0.29 11.1 0.3 1.6 1 0 0 1 1 1 0 Sec20 HAD_2 PF13419.6 CAV20160.1 - 7.2e-41 140.2 0.0 8.7e-41 139.9 0.0 1.1 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 CAV20160.1 - 3.9e-23 82.9 0.1 3.4e-22 79.8 0.1 2.0 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 CAV20160.1 - 1.2e-14 54.1 0.0 2.6e-14 53.0 0.0 1.6 1 0 0 1 1 1 1 HAD-hyrolase-like HAD PF12710.7 CAV20160.1 - 1.9e-13 51.2 0.0 3.2e-13 50.5 0.0 1.4 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 CAV20160.1 - 5.4e-08 32.9 0.0 0.22 11.3 0.0 3.1 3 0 0 3 3 3 3 haloacid dehalogenase-like hydrolase S6PP PF05116.13 CAV20160.1 - 1.5e-05 24.7 0.3 0.00015 21.4 0.0 2.4 2 1 0 2 2 2 1 Sucrose-6F-phosphate phosphohydrolase Acid_phosphat_B PF03767.14 CAV20160.1 - 0.00028 20.5 0.0 0.1 12.2 0.0 2.4 2 1 0 2 2 2 2 HAD superfamily, subfamily IIIB (Acid phosphatase) Hydrolase_6 PF13344.6 CAV20160.1 - 0.00056 20.0 0.0 0.0055 16.8 0.0 2.6 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Acid_PPase PF12689.7 CAV20160.1 - 0.0011 18.9 0.0 1.8 8.4 0.0 2.9 2 1 0 2 2 2 2 Acid Phosphatase Put_Phosphatase PF06888.12 CAV20160.1 - 0.0052 16.2 0.0 22 4.4 0.0 3.0 3 0 0 3 3 3 0 Putative Phosphatase PNK3P PF08645.11 CAV20160.1 - 0.03 14.0 0.0 10 5.8 0.0 3.0 3 0 0 3 3 3 0 Polynucleotide kinase 3 phosphatase Ribul_P_3_epim PF00834.19 CAV20161.1 - 2e-92 308.0 0.1 2.4e-92 307.8 0.1 1.0 1 0 0 1 1 1 1 Ribulose-phosphate 3 epimerase family QRPTase_C PF01729.19 CAV20161.1 - 4.5e-07 29.8 0.3 0.00068 19.4 0.0 2.6 1 1 1 3 3 3 2 Quinolinate phosphoribosyl transferase, C-terminal domain His_biosynth PF00977.21 CAV20161.1 - 0.001 18.6 0.0 0.0045 16.5 0.0 1.9 2 0 0 2 2 2 1 Histidine biosynthesis protein Radical_SAM PF04055.21 CAV20161.1 - 0.025 14.9 0.0 3.6 7.9 0.0 2.6 1 1 1 2 2 2 0 Radical SAM superfamily TMP-TENI PF02581.17 CAV20161.1 - 0.069 12.5 0.0 0.84 8.9 0.0 2.1 2 0 0 2 2 2 0 Thiamine monophosphate synthase VASP_tetra PF08776.11 CAV20161.1 - 0.1 12.2 0.3 0.22 11.1 0.3 1.5 1 0 0 1 1 1 0 VASP tetramerisation domain BKACE PF05853.12 CAV20161.1 - 0.1 11.9 0.1 3.3 6.9 0.0 2.4 2 1 0 2 2 2 0 beta-keto acid cleavage enzyme CutC PF03932.14 CAV20161.1 - 0.11 11.9 0.2 1 8.8 0.0 2.2 2 1 0 2 2 2 0 CutC family MethyltransfD12 PF02086.15 CAV20162.1 - 9.9e-67 225.4 0.0 1.2e-66 225.0 0.0 1.1 1 0 0 1 1 1 1 D12 class N6 adenine-specific DNA methyltransferase AAA_22 PF13401.6 CAV20163.1 - 1.4e-08 35.1 0.0 3.1e-08 34.0 0.0 1.6 1 0 0 1 1 1 1 AAA domain NACHT PF05729.12 CAV20163.1 - 0.00015 21.7 0.7 0.00024 21.1 0.1 1.7 2 0 0 2 2 2 1 NACHT domain SPOR PF05036.13 CAV20163.1 - 0.00027 21.2 0.0 0.00061 20.1 0.0 1.6 1 0 0 1 1 1 1 Sporulation related domain NB-ARC PF00931.22 CAV20163.1 - 0.0011 18.2 0.0 0.0069 15.6 0.0 2.2 1 1 0 1 1 1 1 NB-ARC domain AAA_16 PF13191.6 CAV20163.1 - 0.0012 19.3 1.4 0.014 15.8 1.4 3.0 1 1 0 1 1 1 1 AAA ATPase domain AAA_7 PF12775.7 CAV20163.1 - 0.0096 15.4 0.0 1.9 7.9 0.0 3.1 3 0 0 3 3 3 1 P-loop containing dynein motor region DUF4131 PF13567.6 CAV20163.1 - 0.047 13.3 0.0 0.086 12.5 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) DUF4330 PF14221.6 CAV20163.1 - 0.068 13.4 2.0 0.12 12.5 2.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4330) DHQ_synthase PF01761.20 CAV20164.1 - 6.1e-112 373.1 0.0 7.6e-112 372.7 0.0 1.1 1 0 0 1 1 1 1 3-dehydroquinate synthase Fe-ADH_2 PF13685.6 CAV20164.1 - 4e-12 46.4 0.1 5.9e-11 42.6 0.1 2.1 1 1 0 1 1 1 1 Iron-containing alcohol dehydrogenase Fe-ADH PF00465.19 CAV20164.1 - 1.6e-05 24.0 0.1 6e-05 22.0 0.0 1.8 2 0 0 2 2 2 1 Iron-containing alcohol dehydrogenase Exonuc_VII_L PF02601.15 CAV20164.1 - 0.075 12.6 0.0 0.19 11.3 0.0 1.6 1 0 0 1 1 1 0 Exonuclease VII, large subunit SKI PF01202.22 CAV20165.1 - 4.6e-56 189.3 0.4 5.2e-56 189.1 0.4 1.0 1 0 0 1 1 1 1 Shikimate kinase AAA_33 PF13671.6 CAV20165.1 - 1.5e-07 31.7 0.2 5.3e-07 29.9 0.2 2.0 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.6 CAV20165.1 - 5.1e-07 30.3 0.1 1e-06 29.3 0.1 1.5 1 1 0 1 1 1 1 AAA domain Cytidylate_kin2 PF13189.6 CAV20165.1 - 1.2e-06 28.7 0.1 0.0029 17.7 0.0 2.4 1 1 1 2 2 2 2 Cytidylate kinase-like family Cytidylate_kin PF02224.18 CAV20165.1 - 7.5e-06 25.8 0.1 7.4e-05 22.6 0.0 2.1 2 1 0 2 2 2 1 Cytidylate kinase dNK PF01712.19 CAV20165.1 - 0.00095 19.1 0.1 0.44 10.4 0.0 2.2 2 0 0 2 2 2 2 Deoxynucleoside kinase ABC_tran PF00005.27 CAV20165.1 - 0.0019 18.7 0.3 0.0037 17.8 0.3 1.7 1 1 0 1 1 1 1 ABC transporter APS_kinase PF01583.20 CAV20165.1 - 0.0025 17.7 0.1 0.005 16.7 0.0 1.5 1 1 0 1 1 1 1 Adenylylsulphate kinase AAA_22 PF13401.6 CAV20165.1 - 0.0029 17.9 0.0 0.0031 17.8 0.0 1.5 1 1 0 1 1 1 1 AAA domain TsaE PF02367.17 CAV20165.1 - 0.0031 17.5 0.0 0.0052 16.8 0.0 1.4 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA PF00004.29 CAV20165.1 - 0.0048 17.3 0.0 0.012 16.1 0.0 1.8 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 CAV20165.1 - 0.0056 17.1 0.1 0.0096 16.3 0.1 1.7 1 1 0 1 1 1 1 AAA ATPase domain AAA_17 PF13207.6 CAV20165.1 - 0.01 16.3 0.4 0.051 14.0 0.3 2.1 1 1 0 1 1 1 0 AAA domain AAA_5 PF07728.14 CAV20165.1 - 0.012 15.6 0.1 0.056 13.5 0.0 1.9 1 1 0 2 2 2 0 AAA domain (dynein-related subfamily) Ploopntkinase3 PF18751.1 CAV20165.1 - 0.012 15.5 0.0 0.02 14.8 0.0 1.4 1 0 0 1 1 1 0 P-loop Nucleotide Kinase3 AAA_7 PF12775.7 CAV20165.1 - 0.021 14.3 0.0 0.039 13.5 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_24 PF13479.6 CAV20165.1 - 0.026 14.3 0.0 0.029 14.1 0.0 1.3 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 CAV20165.1 - 0.028 14.8 0.0 0.047 14.1 0.0 1.5 1 0 0 1 1 1 0 RNA helicase Guanylate_kin PF00625.21 CAV20165.1 - 0.04 13.6 0.1 0.16 11.7 0.0 1.8 1 1 1 2 2 2 0 Guanylate kinase AAA_25 PF13481.6 CAV20165.1 - 0.042 13.4 0.0 0.058 13.0 0.0 1.4 1 1 0 1 1 1 0 AAA domain AAA_PrkA PF08298.11 CAV20165.1 - 0.043 12.7 0.0 0.083 11.8 0.0 1.5 1 0 0 1 1 1 0 PrkA AAA domain AAA_29 PF13555.6 CAV20165.1 - 0.046 13.5 0.0 0.078 12.7 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 CAV20165.1 - 0.048 13.6 0.0 0.11 12.4 0.0 1.6 2 0 0 2 2 2 0 RsgA GTPase AAA_28 PF13521.6 CAV20165.1 - 0.048 13.9 0.0 0.21 11.8 0.0 2.0 2 0 0 2 2 2 0 AAA domain CoaE PF01121.20 CAV20165.1 - 0.061 13.0 0.2 0.2 11.3 0.0 1.8 2 1 0 2 2 2 0 Dephospho-CoA kinase Secretin PF00263.21 CAV20166.1 - 6.3e-46 156.1 2.8 1.3e-45 155.1 2.8 1.6 1 0 0 1 1 1 1 Bacterial type II and III secretion system protein Secretin_N PF03958.17 CAV20166.1 - 9e-11 42.0 0.1 2.2e-10 40.8 0.1 1.7 1 0 0 1 1 1 1 Bacterial type II/III secretion system short domain STN PF07660.14 CAV20166.1 - 1.3e-07 31.3 1.3 1.1e-06 28.4 0.2 2.6 2 0 0 2 2 2 1 Secretin and TonB N terminus short domain PilP PF04351.13 CAV20167.1 - 3.2e-41 140.7 0.0 3.7e-41 140.5 0.0 1.0 1 0 0 1 1 1 1 Pilus assembly protein, PilP HofP PF10748.9 CAV20167.1 - 0.0074 15.8 0.1 0.022 14.3 0.0 1.8 1 1 1 2 2 2 1 DNA utilization proteins HofP PilO PF04350.13 CAV20168.1 - 1.9e-47 161.1 1.0 2.4e-47 160.7 1.0 1.1 1 0 0 1 1 1 1 Pilus assembly protein, PilO EMC3_TMCO1 PF01956.16 CAV20168.1 - 0.06 13.1 0.1 0.083 12.6 0.1 1.2 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like DivIC PF04977.15 CAV20168.1 - 0.062 13.1 2.5 0.87 9.4 2.5 2.3 1 1 0 1 1 1 0 Septum formation initiator PilN PF05137.13 CAV20169.1 - 1.9e-12 47.1 0.0 4.1e-12 46.1 0.0 1.6 1 0 0 1 1 1 1 Fimbrial assembly protein (PilN) HemX PF04375.14 CAV20169.1 - 0.018 14.4 1.3 0.018 14.4 1.3 1.5 2 0 0 2 2 2 0 HemX, putative uroporphyrinogen-III C-methyltransferase PilM_2 PF11104.8 CAV20170.1 - 3.6e-43 147.9 0.0 1.9e-40 139.0 0.0 2.0 1 1 0 1 1 1 1 Type IV pilus assembly protein PilM; Transgly PF00912.22 CAV20171.1 - 1.3e-63 213.7 0.0 2.4e-63 212.8 0.0 1.4 1 0 0 1 1 1 1 Transglycosylase PCB_OB PF17092.5 CAV20171.1 - 3e-31 108.5 6.0 6e-31 107.5 6.0 1.6 1 0 0 1 1 1 1 Penicillin-binding protein OB-like domain Transpeptidase PF00905.22 CAV20171.1 - 5.2e-28 98.1 4.1 5e-25 88.3 0.0 2.6 1 1 1 2 2 2 2 Penicillin binding protein transpeptidase domain LysR_substrate PF03466.20 CAV20172.1 - 3.7e-42 144.1 0.0 4.7e-42 143.7 0.0 1.1 1 0 0 1 1 1 1 LysR substrate binding domain HTH_1 PF00126.27 CAV20172.1 - 2.6e-18 65.7 0.0 4.6e-18 64.9 0.0 1.4 1 0 0 1 1 1 1 Bacterial regulatory helix-turn-helix protein, lysR family HTH_30 PF13556.6 CAV20172.1 - 0.0054 16.5 0.0 0.015 15.1 0.0 1.7 1 0 0 1 1 1 1 PucR C-terminal helix-turn-helix domain Redoxin PF08534.10 CAV20173.1 - 3.1e-32 111.3 1.3 1.1e-31 109.5 0.0 2.2 2 1 1 3 3 3 1 Redoxin Glutaredoxin PF00462.24 CAV20173.1 - 1e-18 67.3 0.2 2.8e-18 65.9 0.0 1.9 2 0 0 2 2 2 1 Glutaredoxin AhpC-TSA PF00578.21 CAV20173.1 - 1e-10 41.6 0.1 2.8e-10 40.2 0.0 1.7 2 1 1 3 3 3 1 AhpC/TSA family GST_N_3 PF13417.6 CAV20173.1 - 2.6e-05 24.5 0.0 5e-05 23.6 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 CAV20173.1 - 0.0051 17.1 0.0 0.012 15.9 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain DUF836 PF05768.14 CAV20173.1 - 0.0052 17.2 0.0 0.013 15.9 0.0 1.8 1 0 0 1 1 1 1 Glutaredoxin-like domain (DUF836) Thioredoxin_2 PF13098.6 CAV20173.1 - 0.0075 16.7 0.3 0.025 15.0 0.0 2.0 2 1 0 2 2 2 1 Thioredoxin-like domain Pyr_redox_2 PF07992.14 CAV20174.1 - 1.2e-40 139.6 0.1 1.6e-40 139.2 0.1 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.22 CAV20174.1 - 5.6e-17 62.0 0.0 9.7e-17 61.2 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox_3 PF13738.6 CAV20174.1 - 1e-10 41.4 0.1 2.2e-07 30.5 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 CAV20174.1 - 5.1e-08 33.4 1.9 4.3e-05 24.0 0.0 3.5 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 CAV20174.1 - 0.00019 20.7 3.8 0.0002 20.6 1.3 2.2 2 1 0 2 2 2 1 Glucose inhibited division protein A K_oxygenase PF13434.6 CAV20174.1 - 0.00033 19.9 0.1 0.0074 15.5 0.0 2.4 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) DAO PF01266.24 CAV20174.1 - 0.0077 15.9 1.0 0.017 14.8 0.9 1.7 1 1 0 1 1 1 1 FAD dependent oxidoreductase HI0933_like PF03486.14 CAV20174.1 - 0.013 14.2 0.6 0.28 9.9 0.8 2.1 2 0 0 2 2 2 0 HI0933-like protein FAD_binding_2 PF00890.24 CAV20174.1 - 0.035 13.2 1.1 0.06 12.4 1.1 1.4 1 0 0 1 1 1 0 FAD binding domain AlaDh_PNT_C PF01262.21 CAV20174.1 - 0.33 10.2 2.3 1.7 7.9 0.6 2.2 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain Ribonuc_L-PSP PF01042.21 CAV20176.1 - 3.4e-25 88.4 0.1 3.7e-25 88.3 0.1 1.0 1 0 0 1 1 1 1 Endoribonuclease L-PSP DUF1677 PF07911.13 CAV20176.1 - 0.016 15.6 0.1 0.022 15.2 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1677) DUF3624 PF12292.8 CAV20179.1 - 2.1e-34 117.8 4.5 2.2e-34 117.7 4.5 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3624) EamA PF00892.20 CAV20179.1 - 0.0069 16.6 2.5 0.0083 16.3 2.5 1.1 1 0 0 1 1 1 1 EamA-like transporter family Lyase_1 PF00206.20 CAV20181.1 - 1.7e-88 297.0 0.0 2.7e-88 296.3 0.0 1.3 1 0 0 1 1 1 1 Lyase ASL_C2 PF14698.6 CAV20181.1 - 2.2e-24 86.0 1.2 7.8e-24 84.2 0.1 2.4 2 0 0 2 2 2 1 Argininosuccinate lyase C-terminal Acetyltransf_1 PF00583.25 CAV20181.1 - 5.8e-10 39.4 0.0 1.4e-09 38.2 0.0 1.7 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 CAV20181.1 - 1.9e-05 25.0 0.1 5.3e-05 23.6 0.1 1.7 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 CAV20181.1 - 0.00023 21.1 0.0 0.00061 19.7 0.0 1.7 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Arginosuc_synth PF00764.19 CAV20183.1 - 4.9e-146 487.0 0.0 5.7e-146 486.8 0.0 1.0 1 0 0 1 1 1 1 Arginosuccinate synthase QueC PF06508.13 CAV20183.1 - 0.059 12.9 0.0 0.11 12.0 0.0 1.4 1 0 0 1 1 1 0 Queuosine biosynthesis protein QueC AA_kinase PF00696.28 CAV20184.1 - 2.8e-36 125.3 3.5 3.1e-36 125.2 3.5 1.0 1 0 0 1 1 1 1 Amino acid kinase family Semialdhyde_dh PF01118.24 CAV20185.1 - 2.1e-31 108.9 0.0 5.1e-31 107.6 0.0 1.7 2 0 0 2 2 2 1 Semialdehyde dehydrogenase, NAD binding domain Semialdhyde_dhC PF02774.18 CAV20185.1 - 1.1e-12 48.4 0.0 1.7e-12 47.8 0.0 1.3 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, dimerisation domain DapB_N PF01113.20 CAV20185.1 - 4e-05 23.7 0.0 0.0001 22.4 0.0 1.7 2 0 0 2 2 2 1 Dihydrodipicolinate reductase, N-terminus Peptidase_M20 PF01546.28 CAV20186.1 - 1.1e-32 113.4 0.0 2.5e-32 112.3 0.0 1.5 2 0 0 2 2 2 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 CAV20186.1 - 1.3e-25 89.4 0.0 2.3e-25 88.6 0.0 1.4 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M28 PF04389.17 CAV20186.1 - 0.0011 18.8 0.0 0.0018 18.0 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M28 PHP PF02811.19 CAV20186.1 - 0.11 12.7 0.0 0.28 11.4 0.0 1.7 2 0 0 2 2 2 0 PHP domain PEPcase PF00311.17 CAV20187.1 - 4e-284 944.7 0.0 5.3e-284 944.2 0.0 1.2 1 0 0 1 1 1 1 Phosphoenolpyruvate carboxylase PEPcase_2 PF14010.6 CAV20187.1 - 1.5e-06 27.0 0.0 2.9e-06 26.1 0.0 1.5 1 0 0 1 1 1 1 Phosphoenolpyruvate carboxylase PadR PF03551.14 CAV20188.1 - 1.9e-14 53.4 0.0 4e-14 52.3 0.0 1.5 2 0 0 2 2 2 1 Transcriptional regulator PadR-like family Vir_act_alpha_C PF10400.9 CAV20188.1 - 2.6e-13 50.5 2.7 3.2e-13 50.2 1.6 1.6 2 0 0 2 2 2 1 Virulence activator alpha C-term HTH_34 PF13601.6 CAV20188.1 - 0.0012 19.0 0.0 0.004 17.3 0.0 1.9 2 1 0 2 2 2 1 Winged helix DNA-binding domain RTP PF02334.16 CAV20188.1 - 0.029 15.0 0.0 0.14 12.8 0.0 1.8 2 0 0 2 2 2 0 Replication terminator protein MTHFR PF02219.17 CAV20189.1 - 1e-101 340.1 0.0 1.2e-101 339.8 0.0 1.1 1 0 0 1 1 1 1 Methylenetetrahydrofolate reductase Homoserine_dh PF00742.19 CAV20190.1 - 8.7e-44 149.5 0.0 2.1e-43 148.2 0.0 1.6 1 0 0 1 1 1 1 Homoserine dehydrogenase AA_kinase PF00696.28 CAV20190.1 - 7.2e-42 143.6 0.0 1.5e-41 142.6 0.0 1.5 1 0 0 1 1 1 1 Amino acid kinase family NAD_binding_3 PF03447.16 CAV20190.1 - 2e-14 54.2 0.1 1.5e-13 51.4 0.0 2.7 2 0 0 2 2 2 1 Homoserine dehydrogenase, NAD binding domain Cys_Met_Meta_PP PF01053.20 CAV20191.1 - 4.9e-131 436.8 0.0 5.5e-131 436.6 0.0 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_1_2 PF00155.21 CAV20191.1 - 1.5e-05 24.4 0.0 2.3e-05 23.7 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.19 CAV20191.1 - 0.00083 18.4 0.0 0.0018 17.3 0.0 1.6 1 1 0 1 1 1 1 Aminotransferase class-V Met_gamma_lyase PF06838.11 CAV20191.1 - 0.17 10.4 0.0 0.24 9.9 0.0 1.2 1 0 0 1 1 1 0 Methionine gamma-lyase MetJ PF01340.20 CAV20192.1 - 5.7e-60 199.3 0.1 6.5e-60 199.2 0.1 1.0 1 0 0 1 1 1 1 Met Apo-repressor, MetJ AphA_like PF14557.6 CAV20192.1 - 0.057 13.1 0.0 0.073 12.8 0.0 1.1 1 0 0 1 1 1 0 Putative AphA-like transcriptional regulator malic PF00390.19 CAV20193.1 - 1.4e-29 103.1 1.1 2.3e-20 73.1 0.1 2.6 2 1 1 3 3 3 2 Malic enzyme, N-terminal domain Malic_M PF03949.15 CAV20193.1 - 2.2e-26 92.7 0.0 4.4e-25 88.4 0.0 2.2 1 1 0 1 1 1 1 Malic enzyme, NAD binding domain Malate_DH PF12434.8 CAV20193.1 - 0.011 15.8 0.1 0.034 14.2 0.1 1.9 1 0 0 1 1 1 0 Malate dehydrogenase enzyme ELFV_dehydrog PF00208.21 CAV20193.1 - 0.05 13.3 0.1 0.14 11.9 0.0 1.8 2 0 0 2 2 2 0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase Ribosomal_L31 PF01197.18 CAV20194.1 - 3.6e-32 110.4 0.2 4e-32 110.2 0.2 1.0 1 0 0 1 1 1 1 Ribosomal protein L31 zf-TFIIB PF13453.6 CAV20194.1 - 0.04 13.3 1.1 0.058 12.7 1.1 1.2 1 0 0 1 1 1 0 Transcription factor zinc-finger PriA_3primeBD PF17764.1 CAV20195.1 - 1e-28 99.1 0.0 3.2e-28 97.5 0.0 1.9 2 0 0 2 2 2 1 3′ DNA-binding domain (3′BD) PriA_C PF18074.1 CAV20195.1 - 5.3e-21 75.2 0.1 2.3e-20 73.2 0.0 2.2 2 0 0 2 2 1 1 Primosomal protein N C-terminal domain DEAD PF00270.29 CAV20195.1 - 4.6e-16 59.1 0.0 1.2e-15 57.7 0.0 1.7 2 0 0 2 2 2 1 DEAD/DEAH box helicase ResIII PF04851.15 CAV20195.1 - 8.9e-12 45.3 0.0 1.9e-11 44.2 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 CAV20195.1 - 3e-11 43.7 0.0 2e-07 31.3 0.0 2.7 2 0 0 2 2 2 2 Helicase conserved C-terminal domain PriA_CRR PF18319.1 CAV20195.1 - 6.5e-09 35.6 12.0 6.5e-09 35.6 12.0 3.1 3 0 0 3 3 2 1 PriA DNA helicase Cys-rich region (CRR) domain AAA_30 PF13604.6 CAV20195.1 - 0.003 17.3 0.0 0.0058 16.4 0.0 1.5 1 0 0 1 1 1 1 AAA domain PIF1 PF05970.14 CAV20195.1 - 0.0038 16.5 0.0 0.13 11.4 0.0 2.2 2 0 0 2 2 2 1 PIF1-like helicase TrwB_AAD_bind PF10412.9 CAV20195.1 - 0.007 15.3 0.0 0.012 14.5 0.0 1.3 1 0 0 1 1 1 1 Type IV secretion-system coupling protein DNA-binding domain AAA_19 PF13245.6 CAV20195.1 - 0.016 15.5 0.0 0.058 13.7 0.0 1.9 2 0 0 2 2 2 0 AAA domain Acyltransferase PF01553.21 CAV20195.1 - 0.034 13.7 0.0 0.16 11.6 0.0 2.1 2 0 0 2 2 2 0 Acyltransferase zinc-ribbons_6 PF07191.12 CAV20195.1 - 0.058 13.4 5.7 0.13 12.3 5.7 1.5 1 0 0 1 1 1 0 zinc-ribbons AAA_11 PF13086.6 CAV20195.1 - 0.11 12.2 0.0 0.21 11.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain DUF1258 PF06869.12 CAV20195.1 - 0.6 9.5 6.1 0.51 9.8 0.7 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1258) HypA PF01155.19 CAV20195.1 - 7.6 6.6 10.4 30 4.7 10.4 1.9 1 1 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Peripla_BP_3 PF13377.6 CAV20196.1 - 3.7e-43 147.7 0.0 5.6e-43 147.1 0.0 1.3 1 0 0 1 1 1 1 Periplasmic binding protein-like domain Peripla_BP_1 PF00532.21 CAV20196.1 - 1.3e-34 120.0 0.0 1.7e-34 119.6 0.0 1.1 1 0 0 1 1 1 1 Periplasmic binding proteins and sugar binding domain of LacI family LacI PF00356.21 CAV20196.1 - 9.3e-20 70.2 2.8 1.8e-19 69.3 1.0 2.2 2 0 0 2 2 2 1 Bacterial regulatory proteins, lacI family Peripla_BP_4 PF13407.6 CAV20196.1 - 2.5e-16 60.1 0.0 9.5e-16 58.1 0.0 1.8 1 1 0 1 1 1 1 Periplasmic binding protein domain HTH_38 PF13936.6 CAV20196.1 - 0.00014 21.6 0.1 0.66 9.8 0.0 2.6 2 0 0 2 2 2 2 Helix-turn-helix domain HTH_Tnp_ISL3 PF13542.6 CAV20196.1 - 0.0063 15.9 0.1 0.012 15.0 0.1 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain of transposase family ISL3 HTH_AraC PF00165.23 CAV20196.1 - 0.01 15.9 0.0 6.5 7.0 0.0 2.5 2 0 0 2 2 2 0 Bacterial regulatory helix-turn-helix proteins, AraC family ClpB_D2-small PF10431.9 CAV20196.1 - 0.025 14.6 0.0 0.073 13.1 0.0 1.8 2 0 0 2 2 2 0 C-terminal, D2-small domain, of ClpB protein HTH_Crp_2 PF13545.6 CAV20196.1 - 0.038 14.0 0.5 0.21 11.6 0.1 2.4 3 0 0 3 3 3 0 Crp-like helix-turn-helix domain HTH_10 PF04967.12 CAV20196.1 - 0.083 12.7 0.1 5.8 6.8 0.0 2.6 2 0 0 2 2 2 0 HTH DNA binding domain HTH_23 PF13384.6 CAV20196.1 - 0.085 12.7 0.2 3.2 7.7 0.0 2.7 2 0 0 2 2 2 0 Homeodomain-like domain SPOR PF05036.13 CAV20197.1 - 1.6e-13 50.9 0.0 2.2e-13 50.4 0.0 1.2 1 0 0 1 1 1 1 Sporulation related domain Pex14_N PF04695.13 CAV20197.1 - 0.38 11.4 0.0 0.38 11.4 0.0 2.2 1 1 1 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Proteasome PF00227.26 CAV20198.1 - 2.1e-23 82.8 0.2 3.5e-23 82.1 0.2 1.3 1 1 0 1 1 1 1 Proteasome subunit PspC PF04024.12 CAV20198.1 - 0.19 11.5 0.1 0.35 10.7 0.1 1.4 1 0 0 1 1 1 0 PspC domain AAA_2 PF07724.14 CAV20199.1 - 5.4e-51 173.1 3.2 4.2e-43 147.4 0.6 2.5 2 0 0 2 2 2 2 AAA domain (Cdc48 subfamily) AAA PF00004.29 CAV20199.1 - 3.4e-16 59.9 4.1 3.2e-07 30.8 0.2 3.2 4 2 0 4 4 2 2 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 CAV20199.1 - 6.8e-08 32.6 0.1 8e-06 25.9 0.0 2.7 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 CAV20199.1 - 1.6e-06 28.4 0.1 0.00024 21.4 0.0 3.1 3 0 0 3 3 3 1 AAA domain MCM PF00493.23 CAV20199.1 - 3.8e-06 26.2 0.1 0.0009 18.4 0.0 2.3 2 0 0 2 2 2 1 MCM P-loop domain Mg_chelatase PF01078.21 CAV20199.1 - 2.2e-05 24.0 0.8 0.0024 17.3 0.0 3.5 2 1 2 4 4 4 1 Magnesium chelatase, subunit ChlI ClpB_D2-small PF10431.9 CAV20199.1 - 4.8e-05 23.3 1.2 0.00014 21.9 0.1 2.4 2 0 0 2 2 1 1 C-terminal, D2-small domain, of ClpB protein Sigma54_activat PF00158.26 CAV20199.1 - 8.1e-05 22.4 0.0 0.009 15.7 0.0 2.5 2 0 0 2 2 2 1 Sigma-54 interaction domain AAA_16 PF13191.6 CAV20199.1 - 9.9e-05 22.8 1.1 0.00069 20.0 0.4 2.6 2 1 0 2 2 2 1 AAA ATPase domain IstB_IS21 PF01695.17 CAV20199.1 - 0.0003 20.6 0.4 0.031 14.0 0.0 2.5 1 1 1 2 2 2 1 IstB-like ATP binding protein AAA_18 PF13238.6 CAV20199.1 - 0.00093 19.8 0.1 0.0034 17.9 0.0 2.0 2 0 0 2 2 1 1 AAA domain RuvB_N PF05496.12 CAV20199.1 - 0.0021 17.8 0.1 0.16 11.7 0.0 2.8 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_33 PF13671.6 CAV20199.1 - 0.0032 17.6 0.0 0.008 16.3 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_28 PF13521.6 CAV20199.1 - 0.0058 16.9 1.8 0.012 15.9 0.1 2.4 3 0 0 3 3 3 1 AAA domain TniB PF05621.11 CAV20199.1 - 0.0088 15.5 0.2 0.039 13.4 0.0 2.2 2 0 0 2 2 2 1 Bacterial TniB protein DEAD PF00270.29 CAV20199.1 - 0.013 15.3 1.9 0.072 12.9 1.9 2.5 1 1 0 1 1 1 0 DEAD/DEAH box helicase ABC_tran PF00005.27 CAV20199.1 - 0.018 15.5 0.1 0.041 14.4 0.1 1.7 1 1 0 1 1 1 0 ABC transporter TIP49 PF06068.13 CAV20199.1 - 0.026 13.7 1.2 0.049 12.8 0.1 1.9 2 0 0 2 2 2 0 TIP49 P-loop domain CPT PF07931.12 CAV20199.1 - 0.036 13.9 0.0 0.63 9.9 0.0 2.3 2 0 0 2 2 2 0 Chloramphenicol phosphotransferase-like protein AAA_7 PF12775.7 CAV20199.1 - 0.037 13.6 0.0 0.12 11.9 0.0 1.9 1 1 0 1 1 1 0 P-loop containing dynein motor region SRP54 PF00448.22 CAV20199.1 - 0.037 13.6 0.2 0.11 12.1 0.2 2.0 1 1 0 1 1 1 0 SRP54-type protein, GTPase domain ResIII PF04851.15 CAV20199.1 - 0.04 13.9 0.1 1.5 8.8 0.0 2.6 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit Zeta_toxin PF06414.12 CAV20199.1 - 0.046 13.0 0.5 0.14 11.4 0.1 2.1 2 1 1 3 3 3 0 Zeta toxin AAA_24 PF13479.6 CAV20199.1 - 0.056 13.2 1.9 0.11 12.2 0.1 2.4 3 1 0 3 3 3 0 AAA domain RsgA_GTPase PF03193.16 CAV20199.1 - 0.08 12.8 0.0 0.45 10.4 0.0 2.2 2 0 0 2 2 2 0 RsgA GTPase ATP-synt_ab PF00006.25 CAV20199.1 - 0.092 12.4 0.1 0.2 11.3 0.1 1.5 1 0 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain TsaE PF02367.17 CAV20199.1 - 0.11 12.5 0.0 0.29 11.1 0.0 1.7 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_19 PF13245.6 CAV20199.1 - 0.12 12.7 3.7 0.17 12.2 1.8 2.1 2 1 0 2 2 2 0 AAA domain UbiA PF01040.18 CAV20200.1 - 3.2e-40 138.0 11.8 4e-40 137.7 11.8 1.1 1 0 0 1 1 1 1 UbiA prenyltransferase family Vma12 PF11712.8 CAV20200.1 - 0.19 11.8 0.1 0.41 10.7 0.1 1.6 1 0 0 1 1 1 0 Endoplasmic reticulum-based factor for assembly of V-ATPase Tmemb_14 PF03647.13 CAV20200.1 - 0.19 12.5 18.6 1.5 9.6 7.3 3.4 2 2 1 3 3 3 0 Transmembrane proteins 14C RraA-like PF03737.15 CAV20201.1 - 1.6e-37 129.0 0.0 1.7e-37 128.9 0.0 1.0 1 0 0 1 1 1 1 Aldolase/RraA ZapB PF06005.12 CAV20202.1 - 9.7e-27 93.2 11.7 1.3e-26 92.8 11.7 1.2 1 0 0 1 1 1 1 Cell division protein ZapB PspA_IM30 PF04012.12 CAV20202.1 - 2e-05 24.3 9.4 2.5e-05 24.0 9.4 1.0 1 0 0 1 1 1 1 PspA/IM30 family YabA PF06156.13 CAV20202.1 - 8.1e-05 23.2 5.9 9.4e-05 23.0 5.9 1.1 1 0 0 1 1 1 1 Initiation control protein YabA DHR10 PF18595.1 CAV20202.1 - 0.00011 22.2 10.6 0.00013 22.0 10.6 1.1 1 0 0 1 1 1 1 Designed helical repeat protein 10 domain betaPIX_CC PF16523.5 CAV20202.1 - 0.00064 19.5 3.6 0.00079 19.2 3.6 1.2 1 0 0 1 1 1 1 betaPIX coiled coil APG6_N PF17675.1 CAV20202.1 - 0.00094 19.7 11.2 0.0011 19.5 11.2 1.1 1 0 0 1 1 1 1 Apg6 coiled-coil region DUF5082 PF16888.5 CAV20202.1 - 0.0016 18.7 7.1 0.0031 17.8 7.1 1.3 1 1 0 1 1 1 1 Domain of unknown function (DUF5082) ATG16 PF08614.11 CAV20202.1 - 0.0038 17.5 9.4 0.0044 17.3 9.4 1.0 1 0 0 1 1 1 1 Autophagy protein 16 (ATG16) DUF3450 PF11932.8 CAV20202.1 - 0.0058 16.0 8.8 0.0065 15.8 8.8 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3450) JIP_LZII PF16471.5 CAV20202.1 - 0.0058 16.8 7.9 0.0074 16.4 7.3 1.5 1 1 0 1 1 1 1 JNK-interacting protein leucine zipper II CENP-F_leu_zip PF10473.9 CAV20202.1 - 0.0059 16.6 9.0 0.0068 16.4 9.0 1.2 1 0 0 1 1 1 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Dor1 PF04124.12 CAV20202.1 - 0.0075 15.0 1.6 0.0096 14.6 1.6 1.1 1 0 0 1 1 1 1 Dor1-like family HALZ PF02183.18 CAV20202.1 - 0.0078 16.4 1.0 0.0078 16.4 1.0 2.0 2 1 1 3 3 2 1 Homeobox associated leucine zipper ERM PF00769.19 CAV20202.1 - 0.008 16.0 11.1 0.0088 15.9 11.1 1.0 1 0 0 1 1 1 1 Ezrin/radixin/moesin family CCDC106 PF15794.5 CAV20202.1 - 0.0093 15.7 4.0 0.01 15.6 4.0 1.0 1 0 0 1 1 1 1 Coiled-coil domain-containing protein 106 HAUS-augmin3 PF14932.6 CAV20202.1 - 0.011 15.4 7.6 0.013 15.1 7.6 1.0 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 3 Jnk-SapK_ap_N PF09744.9 CAV20202.1 - 0.011 15.9 11.0 0.02 15.1 11.0 1.4 1 1 0 1 1 1 0 JNK_SAPK-associated protein-1 DUF4201 PF13870.6 CAV20202.1 - 0.013 15.3 5.8 0.015 15.0 5.8 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4201) Spc7 PF08317.11 CAV20202.1 - 0.017 14.0 7.8 0.017 14.0 7.8 1.0 1 0 0 1 1 1 0 Spc7 kinetochore protein NUDE_C PF04880.13 CAV20202.1 - 0.023 15.2 6.9 0.026 15.0 6.9 1.0 1 0 0 1 1 1 0 NUDE protein, C-terminal conserved region DUF724 PF05266.14 CAV20202.1 - 0.03 14.1 6.3 0.036 13.9 6.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF724) HemX PF04375.14 CAV20202.1 - 0.035 13.4 6.4 0.04 13.2 6.4 1.0 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase UPF0242 PF06785.11 CAV20202.1 - 0.037 14.1 7.9 0.043 13.9 7.9 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Mod_r PF07200.13 CAV20202.1 - 0.037 14.1 6.3 0.042 14.0 6.3 1.1 1 0 0 1 1 1 0 Modifier of rudimentary (Mod(r)) protein DUF2203 PF09969.9 CAV20202.1 - 0.039 14.7 5.5 0.043 14.5 5.5 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2203) Tup_N PF08581.10 CAV20202.1 - 0.043 14.1 7.3 0.057 13.7 3.5 2.0 1 1 1 2 2 2 0 Tup N-terminal ADIP PF11559.8 CAV20202.1 - 0.044 13.9 6.4 0.059 13.5 6.4 1.3 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding TMF_TATA_bd PF12325.8 CAV20202.1 - 0.05 13.8 8.6 0.054 13.7 8.6 1.1 1 0 0 1 1 1 0 TATA element modulatory factor 1 TATA binding OmpH PF03938.14 CAV20202.1 - 0.057 13.7 8.6 0.072 13.4 8.6 1.2 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) GAS PF13851.6 CAV20202.1 - 0.06 12.7 9.1 0.12 11.7 9.1 1.5 1 1 0 1 1 1 0 Growth-arrest specific micro-tubule binding AAA_13 PF13166.6 CAV20202.1 - 0.062 11.9 5.5 0.065 11.9 5.5 1.0 1 0 0 1 1 1 0 AAA domain FadA PF09403.10 CAV20202.1 - 0.064 13.7 7.9 0.11 13.0 7.9 1.4 1 1 0 1 1 1 0 Adhesion protein FadA CtIP_N PF10482.9 CAV20202.1 - 0.069 13.2 7.5 0.27 11.3 7.5 1.7 1 1 0 1 1 1 0 Tumour-suppressor protein CtIP N-terminal domain DUF1664 PF07889.12 CAV20202.1 - 0.071 13.2 5.1 0.12 12.4 5.1 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) Herpes_UL6 PF01763.16 CAV20202.1 - 0.072 11.6 2.6 0.078 11.5 2.6 1.0 1 0 0 1 1 1 0 Herpesvirus UL6 like 5_nucleotid PF05761.14 CAV20202.1 - 0.072 12.0 5.7 0.08 11.8 5.7 1.0 1 0 0 1 1 1 0 5' nucleotidase family bZIP_1 PF00170.21 CAV20202.1 - 0.081 13.0 7.7 0.28 11.3 6.1 2.3 1 1 2 3 3 3 0 bZIP transcription factor NPV_P10 PF05531.12 CAV20202.1 - 0.083 13.4 2.1 0.14 12.7 2.1 1.5 1 1 0 1 1 1 0 Nucleopolyhedrovirus P10 protein DUF2968 PF11180.8 CAV20202.1 - 0.089 12.4 8.9 0.1 12.2 8.9 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2968) Seryl_tRNA_N PF02403.22 CAV20202.1 - 0.12 12.7 7.0 0.28 11.4 6.9 1.7 1 1 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain DUF4337 PF14235.6 CAV20202.1 - 0.12 12.5 4.6 0.13 12.4 4.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) Sipho_Gp157 PF05565.11 CAV20202.1 - 0.13 12.3 7.4 0.21 11.6 7.4 1.4 1 1 0 1 1 1 0 Siphovirus Gp157 Spectrin PF00435.21 CAV20202.1 - 0.14 12.7 10.5 1.2 9.7 10.6 1.9 1 1 1 2 2 2 0 Spectrin repeat PDDEXK_1 PF12705.7 CAV20202.1 - 0.14 12.0 2.6 0.15 11.9 2.6 1.0 1 0 0 1 1 1 0 PD-(D/E)XK nuclease superfamily DivIC PF04977.15 CAV20202.1 - 0.14 11.9 12.2 1.7 8.5 1.9 2.1 1 1 1 2 2 2 0 Septum formation initiator FapA PF03961.13 CAV20202.1 - 0.18 10.4 3.2 0.19 10.3 3.2 1.0 1 0 0 1 1 1 0 Flagellar Assembly Protein A K-box PF01486.17 CAV20202.1 - 0.18 12.0 10.5 11 6.3 9.2 2.4 1 1 1 2 2 2 0 K-box region CENP-Q PF13094.6 CAV20202.1 - 0.18 12.0 8.6 0.23 11.7 8.6 1.2 1 0 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit CCDC-167 PF15188.6 CAV20202.1 - 0.21 12.0 4.9 0.3 11.5 4.9 1.2 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 167 DUF4795 PF16043.5 CAV20202.1 - 0.21 11.2 7.2 0.25 10.9 7.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4795) GrpE PF01025.19 CAV20202.1 - 0.21 11.2 6.2 0.3 10.7 6.2 1.3 1 0 0 1 1 1 0 GrpE Atg14 PF10186.9 CAV20202.1 - 0.25 10.4 5.4 0.3 10.1 5.4 1.0 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF349 PF03993.12 CAV20202.1 - 0.33 11.3 9.1 0.54 10.6 9.1 1.5 1 1 0 1 1 1 0 Domain of Unknown Function (DUF349) Prefoldin_2 PF01920.20 CAV20202.1 - 0.34 10.9 11.2 1.5 8.8 6.0 2.1 1 1 1 2 2 2 0 Prefoldin subunit Spc24 PF08286.11 CAV20202.1 - 0.36 11.1 8.8 2 8.7 8.8 1.9 1 1 0 1 1 1 0 Spc24 subunit of Ndc80 DUF465 PF04325.13 CAV20202.1 - 0.44 10.6 8.1 1.9 8.6 2.7 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF465) Rx_N PF18052.1 CAV20202.1 - 0.48 10.7 6.1 0.63 10.4 6.1 1.2 1 0 0 1 1 1 0 Rx N-terminal domain TMPIT PF07851.13 CAV20202.1 - 0.59 9.3 3.7 0.58 9.4 3.7 1.0 1 0 0 1 1 1 0 TMPIT-like protein BST2 PF16716.5 CAV20202.1 - 0.64 10.6 10.4 1 10.0 10.0 1.4 1 1 1 2 2 2 0 Bone marrow stromal antigen 2 DUF2205 PF10224.9 CAV20202.1 - 0.72 9.9 8.7 0.6 10.1 6.2 1.9 1 1 1 2 2 2 0 Short coiled-coil protein zf-C4H2 PF10146.9 CAV20202.1 - 0.73 10.1 6.4 0.81 9.9 6.4 1.1 1 0 0 1 1 1 0 Zinc finger-containing protein GIT_CC PF16559.5 CAV20202.1 - 0.88 9.5 8.3 1.6 8.7 1.2 2.3 1 1 1 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor TolA_bind_tri PF16331.5 CAV20202.1 - 0.89 9.7 10.6 3.6 7.7 10.4 1.8 1 1 0 1 1 1 0 TolA binding protein trimerisation DUF4140 PF13600.6 CAV20202.1 - 1.5 9.3 9.6 15 6.1 9.6 2.0 1 1 0 1 1 1 0 N-terminal domain of unknown function (DUF4140) KfrA_N PF11740.8 CAV20202.1 - 3.7 8.2 12.7 5.8 7.6 12.6 1.4 1 1 0 1 1 1 0 Plasmid replication region DNA-binding N-term AAA_23 PF13476.6 CAV20202.1 - 4.5 7.7 7.5 5.3 7.5 7.5 1.1 1 0 0 1 1 1 0 AAA domain bZIP_2 PF07716.15 CAV20202.1 - 6.6 6.9 13.2 32 4.7 1.6 2.7 1 1 1 3 3 3 0 Basic region leucine zipper SlyX PF04102.12 CAV20202.1 - 9.9 6.9 12.2 47 4.7 12.2 1.9 1 1 0 1 1 1 0 SlyX FBPase_glpX PF03320.13 CAV20203.1 - 4.3e-125 416.7 8.6 4.8e-125 416.5 8.6 1.0 1 0 0 1 1 1 1 Bacterial fructose-1,6-bisphosphatase, glpX-encoded HTH_24 PF13412.6 CAV20204.1 - 7.8e-07 28.6 0.0 2e-06 27.3 0.0 1.8 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding HTH_DeoR PF08220.12 CAV20204.1 - 1.3e-06 28.1 0.4 4.3e-06 26.4 0.0 2.1 2 0 0 2 2 2 1 DeoR-like helix-turn-helix domain HTH_11 PF08279.12 CAV20204.1 - 1.5e-06 28.1 0.0 4.5e-06 26.5 0.0 1.9 2 0 0 2 2 1 1 HTH domain PadR PF03551.14 CAV20204.1 - 1.5e-05 24.8 0.0 0.0005 20.0 0.0 2.9 2 1 0 2 2 2 1 Transcriptional regulator PadR-like family HTH_34 PF13601.6 CAV20204.1 - 0.00012 22.2 0.4 0.00092 19.3 0.0 2.4 3 0 0 3 3 3 1 Winged helix DNA-binding domain Replic_Relax PF13814.6 CAV20204.1 - 0.00055 20.1 0.2 0.00098 19.2 0.2 1.5 1 0 0 1 1 1 1 Replication-relaxation ATC_hydrolase PF14196.6 CAV20204.1 - 0.00074 20.3 0.5 0.0015 19.3 0.5 1.5 1 0 0 1 1 1 1 L-2-amino-thiazoline-4-carboxylic acid hydrolase HTH_20 PF12840.7 CAV20204.1 - 0.001 19.1 0.0 0.0022 18.0 0.0 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain MarR PF01047.22 CAV20204.1 - 0.0036 17.2 0.0 0.0082 16.1 0.0 1.5 1 0 0 1 1 1 1 MarR family MetOD1 PF18546.1 CAV20204.1 - 0.011 15.8 0.1 0.016 15.1 0.1 1.3 1 0 0 1 1 1 0 Metanogen output domain 1 FaeA PF04703.12 CAV20204.1 - 0.012 16.0 0.0 0.022 15.1 0.0 1.5 1 0 0 1 1 1 0 FaeA-like protein DUF2800 PF10926.8 CAV20204.1 - 0.013 14.8 0.4 0.02 14.2 0.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2800) EAP30 PF04157.16 CAV20204.1 - 0.014 14.7 1.1 0.029 13.6 0.0 1.9 2 0 0 2 2 2 0 EAP30/Vps36 family GntR PF00392.21 CAV20204.1 - 0.019 14.6 0.0 0.046 13.4 0.0 1.7 1 0 0 1 1 1 0 Bacterial regulatory proteins, gntR family DDRGK PF09756.9 CAV20204.1 - 0.022 14.4 0.6 0.044 13.4 0.0 1.8 2 0 0 2 2 2 0 DDRGK domain HTH_IclR PF09339.10 CAV20204.1 - 0.041 13.7 0.0 0.1 12.4 0.0 1.7 1 0 0 1 1 1 0 IclR helix-turn-helix domain Ribosomal_S25 PF03297.15 CAV20204.1 - 0.044 14.0 0.0 0.085 13.1 0.0 1.5 1 0 0 1 1 1 0 S25 ribosomal protein TFIIE_alpha PF02002.17 CAV20204.1 - 0.065 13.1 0.0 0.14 12.0 0.0 1.5 1 0 0 1 1 1 0 TFIIE alpha subunit HTH_5 PF01022.20 CAV20204.1 - 0.069 13.0 0.0 0.21 11.5 0.0 1.8 1 0 0 1 1 1 0 Bacterial regulatory protein, arsR family MarR_2 PF12802.7 CAV20204.1 - 0.15 12.0 0.0 0.33 10.9 0.0 1.6 1 0 0 1 1 1 0 MarR family DUF3135 PF11333.8 CAV20205.1 - 1.2e-33 115.2 2.2 1.4e-33 114.9 2.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3135) LRV_FeS PF05484.11 CAV20205.1 - 0.072 13.1 0.9 0.19 11.7 0.5 1.9 2 0 0 2 2 2 0 LRV protein FeS4 cluster DUF805 PF05656.14 CAV20206.1 - 3.1e-21 75.8 0.4 3.7e-21 75.5 0.4 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF805) YwiC PF14256.6 CAV20206.1 - 0.19 12.1 6.3 0.38 11.1 0.2 2.2 2 0 0 2 2 2 0 YwiC-like protein CHMI PF02962.15 CAV20207.1 - 2.1e-19 70.1 0.0 2.4e-19 69.9 0.0 1.1 1 0 0 1 1 1 1 5-carboxymethyl-2-hydroxymuconate isomerase Tautomerase_2 PF14552.6 CAV20207.1 - 6e-05 23.1 0.0 7.7e-05 22.7 0.0 1.2 1 0 0 1 1 1 1 Tautomerase enzyme Tautomerase PF01361.21 CAV20207.1 - 0.062 13.2 0.1 0.15 12.0 0.0 1.9 2 0 0 2 2 2 0 Tautomerase enzyme TIM PF00121.18 CAV20209.1 - 4.8e-85 284.8 0.1 5.4e-85 284.6 0.1 1.0 1 0 0 1 1 1 1 Triosephosphate isomerase PFK PF00365.20 CAV20210.1 - 1.8e-109 365.5 3.4 2.2e-109 365.2 3.4 1.1 1 0 0 1 1 1 1 Phosphofructokinase NAD_kinase PF01513.21 CAV20210.1 - 0.023 13.9 0.0 0.036 13.3 0.0 1.2 1 0 0 1 1 1 0 ATP-NAD kinase Cation_efflux PF01545.21 CAV20211.1 - 4.8e-45 153.8 15.6 5.7e-45 153.5 15.6 1.1 1 0 0 1 1 1 1 Cation efflux family ZT_dimer PF16916.5 CAV20211.1 - 1.3e-26 92.6 0.2 2.2e-26 91.8 0.2 1.4 1 0 0 1 1 1 1 Dimerisation domain of Zinc Transporter IncE PF17627.2 CAV20211.1 - 0.042 13.9 2.2 0.058 13.4 0.1 2.1 2 0 0 2 2 2 0 Inclusion membrane protein E DUF4234 PF14018.6 CAV20211.1 - 2.1 8.6 4.8 0.36 11.0 0.6 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4234) LTXXQ PF07813.12 CAV20212.1 - 2.3e-20 73.2 21.8 2.3e-20 73.2 21.8 1.9 1 1 1 2 2 2 1 LTXXQ motif family protein Metal_resist PF13801.6 CAV20212.1 - 3.5e-08 33.7 8.7 1.7e-07 31.4 8.7 2.0 1 1 0 1 1 1 1 Heavy-metal resistance HBS1_N PF08938.10 CAV20212.1 - 7.9 6.9 9.4 3e+02 1.8 9.4 2.5 1 1 0 1 1 1 0 HBS1 N-terminus Response_reg PF00072.24 CAV20213.1 - 1.5e-27 96.0 0.1 2.5e-27 95.2 0.1 1.4 1 0 0 1 1 1 1 Response regulator receiver domain Trans_reg_C PF00486.28 CAV20213.1 - 4.7e-21 74.7 0.5 9.9e-21 73.6 0.0 1.8 2 0 0 2 2 2 1 Transcriptional regulatory protein, C terminal FleQ PF06490.11 CAV20213.1 - 0.06 13.7 0.0 0.088 13.2 0.0 1.3 1 0 0 1 1 1 0 Flagellar regulatory protein FleQ DEK_C PF08766.11 CAV20213.1 - 0.061 13.2 0.8 7.6 6.6 0.0 3.3 3 0 0 3 3 3 0 DEK C terminal domain CpxA_peri PF16527.5 CAV20214.1 - 2.1e-55 186.8 0.6 4.9e-55 185.6 0.0 1.9 2 0 0 2 2 2 1 Two-component sensor protein CpxA, periplasmic domain HATPase_c PF02518.26 CAV20214.1 - 2.1e-17 63.7 0.0 1.4e-16 61.0 0.0 2.1 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HAMP PF00672.25 CAV20214.1 - 5.5e-12 45.9 0.0 1.6e-11 44.4 0.0 1.9 1 0 0 1 1 1 1 HAMP domain HisKA PF00512.25 CAV20214.1 - 7.8e-11 41.9 4.5 3.3e-10 39.8 4.5 2.0 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain HATPase_c_3 PF13589.6 CAV20214.1 - 2.3e-05 24.2 0.0 4.5e-05 23.3 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_2 PF13581.6 CAV20214.1 - 0.055 13.4 0.0 0.11 12.5 0.0 1.6 1 0 0 1 1 1 0 Histidine kinase-like ATPase domain Clusterin PF01093.17 CAV20214.1 - 0.1 11.6 0.9 0.15 11.0 0.9 1.2 1 0 0 1 1 1 0 Clusterin Sod_Fe_C PF02777.18 CAV20215.1 - 1.4e-39 134.3 0.5 1.4e-39 134.3 0.5 1.7 2 0 0 2 2 2 1 Iron/manganese superoxide dismutases, C-terminal domain Sod_Fe_N PF00081.22 CAV20215.1 - 4.4e-27 94.4 1.2 4.4e-27 94.4 1.2 1.6 2 0 0 2 2 2 1 Iron/manganese superoxide dismutases, alpha-hairpin domain SpoU_methylase PF00588.19 CAV20216.1 - 3.4e-35 121.3 0.0 3.8e-35 121.1 0.0 1.0 1 0 0 1 1 1 1 SpoU rRNA Methylase family FxsA PF04186.13 CAV20217.1 - 1.6e-35 121.5 11.7 2.3e-35 121.0 11.7 1.1 1 0 0 1 1 1 1 FxsA cytoplasmic membrane protein Lyase_1 PF00206.20 CAV20218.1 - 7.4e-102 340.9 0.0 9e-102 340.6 0.0 1.1 1 0 0 1 1 1 1 Lyase FumaraseC_C PF10415.9 CAV20218.1 - 2.4e-18 66.3 0.0 7.8e-18 64.6 0.0 2.0 1 0 0 1 1 1 1 Fumarase C C-terminus DcuA_DcuB PF03605.14 CAV20219.1 - 3.4e-145 483.6 32.6 4e-145 483.3 32.6 1.1 1 0 0 1 1 1 1 Anaerobic c4-dicarboxylate membrane transporter CitMHS PF03600.16 CAV20219.1 - 0.48 9.6 51.9 0.55 9.4 48.7 2.1 1 1 1 2 2 2 0 Citrate transporter DUF1516 PF07457.11 CAV20219.1 - 1.2 9.4 0.1 1.2 9.4 0.1 3.4 3 1 0 3 3 3 0 Protein of unknown function (DUF1516) DcuC PF03606.15 CAV20220.1 - 4.3e-136 454.1 35.3 4.8e-136 453.9 35.3 1.0 1 0 0 1 1 1 1 C4-dicarboxylate anaerobic carrier HRG PF16954.5 CAV20220.1 - 0.022 15.1 0.0 0.022 15.1 0.0 3.9 4 1 0 4 4 4 0 Haem-transporter, endosomal/lysosomal, haem-responsive gene Amidinotransf PF02274.17 CAV20221.1 - 9.2e-110 366.9 0.0 1e-109 366.7 0.0 1.0 1 0 0 1 1 1 1 Amidinotransferase AA_kinase PF00696.28 CAV20222.1 - 1.1e-28 100.5 0.0 2.5e-28 99.3 0.0 1.5 1 1 0 1 1 1 1 Amino acid kinase family SKI PF01202.22 CAV20222.1 - 0.0063 16.6 0.0 0.048 13.8 0.0 2.2 2 0 0 2 2 2 1 Shikimate kinase ADH_zinc_N PF00107.26 CAV20222.1 - 0.012 15.6 0.0 0.045 13.7 0.0 2.0 1 1 0 1 1 1 0 Zinc-binding dehydrogenase OTCace PF00185.24 CAV20223.1 - 6.2e-58 195.3 0.4 9.6e-58 194.7 0.4 1.3 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain OTCace_N PF02729.21 CAV20223.1 - 1.4e-45 155.0 0.0 2.1e-45 154.4 0.0 1.3 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain OTCace_N PF02729.21 CAV20224.1 - 5.8e-45 152.9 0.0 9.2e-45 152.3 0.0 1.3 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain OTCace PF00185.24 CAV20224.1 - 4.6e-34 117.8 0.1 6.4e-34 117.3 0.1 1.2 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain BRCT PF00533.26 CAV20224.1 - 9e-05 22.8 0.0 0.0013 19.1 0.0 2.6 2 0 0 2 2 2 1 BRCA1 C Terminus (BRCT) domain PyrI PF01948.18 CAV20225.1 - 2.6e-30 104.5 0.6 3.6e-30 104.1 0.6 1.2 1 0 0 1 1 1 1 Aspartate carbamoyltransferase regulatory chain, allosteric domain PyrI_C PF02748.15 CAV20225.1 - 1.2e-18 66.7 4.3 2.4e-18 65.7 4.3 1.5 1 0 0 1 1 1 1 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-C2H2 PF00096.26 CAV20225.1 - 0.12 12.9 0.1 0.12 12.9 0.1 1.9 2 0 0 2 2 2 0 Zinc finger, C2H2 type Arg_repressor_C PF02863.18 CAV20226.1 - 3.9e-16 58.6 0.9 5.9e-16 58.1 0.9 1.3 1 0 0 1 1 1 1 Arginine repressor, C-terminal domain Arg_repressor PF01316.21 CAV20226.1 - 5.3e-14 51.7 1.5 8.9e-14 51.0 0.4 1.9 2 0 0 2 2 2 1 Arginine repressor, DNA binding domain YcgR PF07317.12 CAV20226.1 - 0.023 14.5 0.0 0.057 13.3 0.0 1.6 2 0 0 2 2 2 0 Flagellar regulator YcgR LacI PF00356.21 CAV20226.1 - 0.056 13.2 0.1 0.11 12.3 0.1 1.4 1 0 0 1 1 1 0 Bacterial regulatory proteins, lacI family HTH_32 PF13565.6 CAV20226.1 - 0.086 13.5 0.1 0.24 12.0 0.0 1.7 2 0 0 2 2 2 0 Homeodomain-like domain HTH_ABP1_N PF18107.1 CAV20226.1 - 0.21 11.3 1.6 0.37 10.6 1.7 1.5 1 1 0 1 1 1 0 Fission yeast centromere protein N-terminal domain DsbC PF11412.8 CAV20227.1 - 1.4e-28 99.4 0.3 2.2e-28 98.7 0.3 1.3 1 0 0 1 1 1 1 Disulphide bond corrector protein DsbC DsbD PF02683.15 CAV20227.1 - 2e-19 70.3 18.6 2.8e-19 69.9 18.6 1.2 1 0 0 1 1 1 1 Cytochrome C biogenesis protein transmembrane region Thioredoxin_7 PF13899.6 CAV20227.1 - 8.6e-11 41.9 0.1 2.2e-10 40.6 0.1 1.7 1 0 0 1 1 1 1 Thioredoxin-like Thioredoxin_2 PF13098.6 CAV20227.1 - 1.6e-10 41.4 0.0 3.6e-10 40.2 0.0 1.6 1 0 0 1 1 1 1 Thioredoxin-like domain DsbD_2 PF13386.6 CAV20227.1 - 6.2e-10 39.3 26.5 2.9e-09 37.1 16.3 2.3 1 1 1 2 2 2 2 Cytochrome C biogenesis protein transmembrane region Thioredoxin PF00085.20 CAV20227.1 - 4.8e-08 32.9 0.0 8.7e-08 32.1 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_8 PF13905.6 CAV20227.1 - 0.097 13.0 0.1 0.28 11.5 0.1 1.8 1 1 0 1 1 1 0 Thioredoxin-like Response_reg PF00072.24 CAV20228.1 - 2.2e-23 82.6 0.0 3.5e-23 81.9 0.0 1.3 1 0 0 1 1 1 1 Response regulator receiver domain GerE PF00196.19 CAV20228.1 - 6e-20 70.6 0.1 9e-20 70.0 0.1 1.3 1 0 0 1 1 1 1 Bacterial regulatory proteins, luxR family Sigma70_r4_2 PF08281.12 CAV20228.1 - 0.00041 20.0 0.1 0.00086 18.9 0.1 1.5 1 0 0 1 1 1 1 Sigma-70, region 4 Sigma70_ECF PF07638.11 CAV20228.1 - 0.0011 18.9 0.0 0.0019 18.1 0.0 1.4 1 1 0 1 1 1 1 ECF sigma factor Sigma70_r4 PF04545.16 CAV20228.1 - 0.013 15.0 0.0 0.037 13.5 0.0 1.7 1 1 0 1 1 1 0 Sigma-70, region 4 HTH_40 PF14493.6 CAV20228.1 - 0.028 14.9 0.1 0.057 13.9 0.1 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain DUF2089 PF09862.9 CAV20228.1 - 0.059 13.4 0.0 0.11 12.5 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2089) Phage_terminase PF10668.9 CAV20228.1 - 0.094 12.7 0.0 0.19 11.8 0.0 1.4 1 0 0 1 1 1 0 Phage terminase small subunit HTH_7 PF02796.15 CAV20228.1 - 0.11 12.6 0.0 0.27 11.4 0.0 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain of resolvase DUF374 PF04028.13 CAV20228.1 - 0.16 11.5 0.0 0.38 10.3 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF374) HTH_11 PF08279.12 CAV20228.1 - 0.19 11.7 0.3 0.74 9.8 0.0 2.1 3 0 0 3 3 3 0 HTH domain Na_H_Exchanger PF00999.21 CAV20229.1 - 4.4e-55 187.0 45.1 6.2e-55 186.5 45.1 1.0 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family TrkA_C PF02080.21 CAV20229.1 - 7.7e-13 48.1 0.0 1.5e-12 47.2 0.0 1.5 1 0 0 1 1 1 1 TrkA-C domain CorC_HlyC PF03471.17 CAV20229.1 - 3.4e-05 23.8 0.0 6.6e-05 22.8 0.0 1.4 1 0 0 1 1 1 1 Transporter associated domain DUF4212 PF13937.6 CAV20230.1 - 3e-35 120.5 5.7 3.3e-35 120.3 5.7 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4212) DUF485 PF04341.12 CAV20230.1 - 0.064 13.2 4.2 0.08 12.9 4.2 1.1 1 0 0 1 1 1 0 Protein of unknown function, DUF485 SSF PF00474.17 CAV20231.1 - 2.5e-52 178.1 32.2 1.8e-33 116.0 20.6 2.1 2 0 0 2 2 2 2 Sodium:solute symporter family AP-5_subunit_s1 PF15001.6 CAV20232.1 - 0.019 14.9 3.2 0.31 11.0 0.5 2.4 1 1 1 2 2 2 0 AP-5 complex subunit sigma-1 Lyase_1 PF00206.20 CAV20233.1 - 4.2e-91 305.6 3.5 5.3e-91 305.3 3.5 1.1 1 0 0 1 1 1 1 Lyase FumaraseC_C PF10415.9 CAV20233.1 - 2e-19 69.8 0.2 5.7e-19 68.3 0.2 1.9 1 0 0 1 1 1 1 Fumarase C C-terminus PAS_7 PF12860.7 CAV20234.1 - 1e-43 148.2 0.0 2.2e-43 147.1 0.0 1.6 1 0 0 1 1 1 1 PAS fold HATPase_c PF02518.26 CAV20234.1 - 3.5e-19 69.4 0.0 7.3e-19 68.3 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 CAV20234.1 - 7.3e-12 45.4 0.0 1.5e-11 44.5 0.0 1.5 1 0 0 1 1 1 1 Response regulator receiver domain HisKA PF00512.25 CAV20234.1 - 2.9e-11 43.2 0.5 1e-10 41.4 0.5 2.1 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain PAS_8 PF13188.7 CAV20234.1 - 1e-05 25.4 0.0 3.5e-05 23.7 0.0 1.9 1 0 0 1 1 1 1 PAS domain PAS_4 PF08448.10 CAV20234.1 - 2.1e-05 24.7 0.0 5.6e-05 23.4 0.0 1.8 1 0 0 1 1 1 1 PAS fold PAS PF00989.25 CAV20234.1 - 0.0003 20.8 0.0 0.00066 19.7 0.0 1.6 1 0 0 1 1 1 1 PAS fold HATPase_c_2 PF13581.6 CAV20234.1 - 0.016 15.1 0.0 0.043 13.8 0.0 1.6 1 0 0 1 1 1 0 Histidine kinase-like ATPase domain PAS_10 PF13596.6 CAV20234.1 - 0.12 13.0 0.0 0.31 11.6 0.0 1.7 1 0 0 1 1 1 0 PAS domain OmpH PF03938.14 CAV20234.1 - 1.2 9.5 4.6 2.5 8.5 4.6 1.5 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) MFS_1_like PF12832.7 CAV20235.1 - 6.2e-39 133.9 28.7 2e-38 132.3 28.7 1.6 1 1 0 1 1 1 1 MFS_1 like family MFS_1 PF07690.16 CAV20235.1 - 6.9e-11 41.7 55.2 7.8e-10 38.2 35.2 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily LacY_symp PF01306.19 CAV20235.1 - 2.6e-06 26.5 25.8 8.1e-06 24.9 25.8 1.7 1 1 0 1 1 1 1 LacY proton/sugar symporter DUF294 PF03445.13 CAV20236.1 - 6e-43 146.0 0.1 1.6e-42 144.6 0.1 1.7 1 0 0 1 1 1 1 Putative nucleotidyltransferase DUF294 DUF294_C PF10335.9 CAV20236.1 - 3.4e-37 127.4 0.1 1.3e-36 125.5 0.0 2.0 2 0 0 2 2 2 1 Putative nucleotidyltransferase substrate binding domain CBS PF00571.28 CAV20236.1 - 3.4e-08 33.8 0.1 0.01 16.2 0.0 3.1 2 0 0 2 2 2 2 CBS domain cNMP_binding PF00027.29 CAV20236.1 - 6.2e-08 32.6 0.0 1.3e-07 31.6 0.0 1.6 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain RNase_T PF00929.24 CAV20237.1 - 2.7e-17 63.8 0.0 3.2e-17 63.6 0.0 1.1 1 0 0 1 1 1 1 Exonuclease DUF5051 PF16473.5 CAV20237.1 - 1.8e-05 24.8 0.0 7.8e-05 22.7 0.0 1.9 1 1 0 1 1 1 1 3' exoribonuclease, RNase T-like DNA_pol_A_exo1 PF01612.20 CAV20237.1 - 0.00058 19.6 0.1 0.0044 16.7 0.1 2.0 1 1 0 1 1 1 1 3'-5' exonuclease AMP-binding PF00501.28 CAV20238.1 - 3e-88 296.3 0.0 3.6e-88 296.0 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 CAV20238.1 - 2.7e-24 85.9 0.0 6.9e-24 84.6 0.0 1.7 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain ACAS_N PF16177.5 CAV20238.1 - 1.5e-21 76.0 0.7 5.7e-21 74.2 0.1 2.3 2 0 0 2 2 2 1 Acetyl-coenzyme A synthetase N-terminus DHquinase_II PF01220.19 CAV20239.1 - 5.2e-62 207.6 0.1 6e-62 207.4 0.1 1.0 1 0 0 1 1 1 1 Dehydroquinase class II Biotin_lipoyl PF00364.22 CAV20240.1 - 5.4e-24 83.8 2.1 5.7e-24 83.7 0.7 1.7 2 0 0 2 2 2 1 Biotin-requiring enzyme Biotin_lipoyl_2 PF13533.6 CAV20240.1 - 3.3e-08 33.2 0.5 3.3e-05 23.6 0.5 2.5 1 1 1 2 2 2 2 Biotin-lipoyl like RnfC_N PF13375.6 CAV20240.1 - 0.00058 19.8 0.8 0.0013 18.6 0.5 1.8 1 1 1 2 2 2 1 RnfC Barrel sandwich hybrid domain YqfD PF06898.11 CAV20240.1 - 0.034 13.0 0.4 0.28 10.0 0.1 2.0 1 1 1 2 2 2 0 Putative stage IV sporulation protein YqfD GCV_H PF01597.19 CAV20240.1 - 0.042 13.7 0.2 0.1 12.5 0.2 1.6 1 1 1 2 2 2 0 Glycine cleavage H-protein QRPTase_N PF02749.16 CAV20240.1 - 0.066 13.3 0.1 3.7 7.7 0.0 2.3 1 1 1 2 2 2 0 Quinolinate phosphoribosyl transferase, N-terminal domain HlyD_D23 PF16576.5 CAV20240.1 - 0.1 11.8 0.3 1.9 7.7 0.0 2.5 2 1 1 3 3 3 0 Barrel-sandwich domain of CusB or HlyD membrane-fusion CPSase_L_D2 PF02786.17 CAV20241.1 - 7.9e-84 280.4 0.1 1.2e-83 279.8 0.1 1.3 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Biotin_carb_N PF00289.22 CAV20241.1 - 1.2e-43 148.1 0.1 5.4e-43 146.0 0.0 2.1 2 0 0 2 2 2 1 Biotin carboxylase, N-terminal domain Biotin_carb_C PF02785.19 CAV20241.1 - 3.4e-36 123.6 0.0 6.9e-36 122.6 0.0 1.6 1 0 0 1 1 1 1 Biotin carboxylase C-terminal domain Dala_Dala_lig_C PF07478.13 CAV20241.1 - 1.5e-10 41.0 0.0 1e-09 38.2 0.0 2.2 2 1 0 2 2 2 1 D-ala D-ala ligase C-terminus ATP-grasp PF02222.22 CAV20241.1 - 7.5e-09 35.4 0.1 1.7e-08 34.2 0.1 1.5 1 0 0 1 1 1 1 ATP-grasp domain ATP-grasp_3 PF02655.14 CAV20241.1 - 1.9e-08 34.5 0.0 3.4e-08 33.7 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp domain ATP-grasp_4 PF13535.6 CAV20241.1 - 0.0021 17.7 0.0 0.0085 15.7 0.0 2.2 1 1 0 1 1 1 1 ATP-grasp domain GARS_A PF01071.19 CAV20241.1 - 0.0027 17.5 0.0 0.005 16.6 0.0 1.5 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain RimK PF08443.11 CAV20241.1 - 0.0064 16.1 0.0 0.021 14.4 0.0 1.8 1 1 0 1 1 1 1 RimK-like ATP-grasp domain PrmA PF06325.13 CAV20242.1 - 1.1e-103 346.7 0.0 1.2e-103 346.6 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_31 PF13847.6 CAV20242.1 - 6.6e-11 42.2 0.0 1.1e-10 41.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 CAV20242.1 - 2.2e-09 37.1 0.0 3.5e-09 36.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_23 PF13489.6 CAV20242.1 - 7.6e-08 32.4 0.0 1.3e-07 31.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CAV20242.1 - 1.1e-07 32.4 0.0 2.5e-07 31.3 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CAV20242.1 - 1.7e-06 28.7 0.0 3.9e-06 27.5 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CAV20242.1 - 4.7e-06 27.2 0.0 1.3e-05 25.8 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Met_10 PF02475.16 CAV20242.1 - 6.6e-05 22.7 0.0 0.0001 22.1 0.0 1.2 1 0 0 1 1 1 1 Met-10+ like-protein PCMT PF01135.19 CAV20242.1 - 7.2e-05 22.6 0.0 0.00011 22.1 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Cons_hypoth95 PF03602.15 CAV20242.1 - 0.00014 21.5 0.0 0.00023 20.8 0.0 1.3 1 0 0 1 1 1 1 Conserved hypothetical protein 95 Methyltransf_18 PF12847.7 CAV20242.1 - 0.00016 21.6 0.0 0.00027 20.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_9 PF08003.11 CAV20242.1 - 0.00037 19.5 0.0 0.00056 18.9 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) Methyltransf_32 PF13679.6 CAV20242.1 - 0.00045 20.2 0.0 0.00072 19.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 CAV20242.1 - 0.0018 17.6 0.0 0.0031 16.9 0.0 1.3 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase N6_N4_Mtase PF01555.18 CAV20242.1 - 0.0023 17.7 0.0 0.0069 16.1 0.0 1.5 1 1 0 1 1 1 1 DNA methylase Ubie_methyltran PF01209.18 CAV20242.1 - 0.017 14.5 0.0 0.035 13.5 0.0 1.4 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family Methyltransf_15 PF09445.10 CAV20242.1 - 0.021 14.4 0.0 0.03 13.9 0.0 1.2 1 0 0 1 1 1 0 RNA cap guanine-N2 methyltransferase UPF0020 PF01170.18 CAV20242.1 - 0.12 12.0 0.7 0.54 9.9 0.7 1.9 1 1 0 1 1 1 0 Putative RNA methylase family UPF0020 Dus PF01207.17 CAV20243.1 - 6.3e-110 367.1 0.0 7.2e-110 366.9 0.0 1.0 1 0 0 1 1 1 1 Dihydrouridine synthase (Dus) His_biosynth PF00977.21 CAV20243.1 - 1.1e-05 25.0 0.1 2.3e-05 23.9 0.1 1.5 1 1 0 1 1 1 1 Histidine biosynthesis protein NanE PF04131.14 CAV20243.1 - 0.00033 19.9 0.1 0.00093 18.4 0.0 1.7 1 1 0 1 1 1 1 Putative N-acetylmannosamine-6-phosphate epimerase SOR_SNZ PF01680.17 CAV20243.1 - 0.0012 18.7 0.5 0.15 11.8 0.1 2.3 1 1 1 2 2 2 1 SOR/SNZ family DHO_dh PF01180.21 CAV20243.1 - 0.0021 17.3 0.2 0.067 12.4 0.1 2.1 1 1 1 2 2 2 1 Dihydroorotate dehydrogenase Oxidored_FMN PF00724.20 CAV20243.1 - 0.0063 15.8 0.0 0.27 10.5 0.0 2.3 2 0 0 2 2 2 1 NADH:flavin oxidoreductase / NADH oxidase family PEP_mutase PF13714.6 CAV20243.1 - 0.046 13.2 0.1 0.077 12.4 0.1 1.3 1 0 0 1 1 1 0 Phosphoenolpyruvate phosphomutase ThiG PF05690.14 CAV20243.1 - 0.052 12.8 0.9 0.21 10.9 0.0 2.2 2 1 0 2 2 2 0 Thiazole biosynthesis protein ThiG Radical_SAM PF04055.21 CAV20243.1 - 0.071 13.5 0.0 1.2 9.5 0.0 2.1 1 1 1 2 2 2 0 Radical SAM superfamily NMO PF03060.15 CAV20243.1 - 0.094 12.1 0.8 0.2 11.0 0.0 1.9 2 1 1 3 3 3 0 Nitronate monooxygenase NTP_transf_9 PF04248.12 CAV20243.1 - 0.12 12.3 0.0 0.25 11.3 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF427) HTH_8 PF02954.19 CAV20244.1 - 2.4e-14 52.8 0.3 4.2e-14 52.1 0.3 1.4 1 0 0 1 1 1 1 Bacterial regulatory protein, Fis family Phage_NinH PF06322.11 CAV20244.1 - 0.00047 20.0 0.2 0.00099 19.0 0.2 1.5 1 0 0 1 1 1 1 Phage NinH protein HTH_30 PF13556.6 CAV20244.1 - 0.0082 15.9 0.1 0.02 14.7 0.1 1.7 1 0 0 1 1 1 1 PucR C-terminal helix-turn-helix domain HTH_28 PF13518.6 CAV20244.1 - 0.16 12.1 0.0 0.27 11.4 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain GGDEF PF00990.21 CAV20245.1 - 9.3e-44 149.0 0.0 1.4e-43 148.4 0.0 1.3 1 0 0 1 1 1 1 Diguanylate cyclase, GGDEF domain GGDEF_2 PF17853.1 CAV20245.1 - 0.01 16.1 0.0 0.026 14.8 0.0 1.6 2 0 0 2 2 2 0 GGDEF-like domain MerR PF00376.23 CAV20246.1 - 2e-16 59.4 0.0 3.9e-16 58.5 0.0 1.5 1 0 0 1 1 1 1 MerR family regulatory protein MerR_1 PF13411.6 CAV20246.1 - 2.9e-16 59.3 0.0 5.7e-16 58.4 0.0 1.5 1 0 0 1 1 1 1 MerR HTH family regulatory protein MerR-DNA-bind PF09278.11 CAV20246.1 - 1.1e-15 57.9 1.7 1.8e-15 57.2 1.7 1.4 1 0 0 1 1 1 1 MerR, DNA binding HTH_3 PF01381.22 CAV20246.1 - 0.045 13.8 0.0 0.81 9.8 0.0 2.2 2 0 0 2 2 2 0 Helix-turn-helix BTAD PF03704.17 CAV20246.1 - 0.13 12.7 0.2 0.31 11.5 0.1 1.7 2 0 0 2 2 2 0 Bacterial transcriptional activator domain AICARFT_IMPCHas PF01808.18 CAV20247.1 - 8.5e-120 399.7 4.3 1.1e-119 399.4 4.3 1.1 1 0 0 1 1 1 1 AICARFT/IMPCHase bienzyme MGS PF02142.22 CAV20247.1 - 3.6e-31 107.2 0.0 9.6e-31 105.8 0.0 1.8 1 0 0 1 1 1 1 MGS-like domain CoA_binding_2 PF13380.6 CAV20247.1 - 0.16 12.5 3.5 0.94 10.0 0.0 3.2 4 1 1 5 5 5 0 CoA binding domain GARS_A PF01071.19 CAV20248.1 - 6.4e-82 274.0 0.0 8.7e-82 273.6 0.0 1.2 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain GARS_N PF02844.15 CAV20248.1 - 9e-35 119.3 0.4 1.9e-34 118.3 0.4 1.6 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, N domain GARS_C PF02843.16 CAV20248.1 - 1.4e-29 102.2 1.3 7.8e-29 99.8 0.2 2.4 3 0 0 3 3 3 1 Phosphoribosylglycinamide synthetase, C domain ATP-grasp_3 PF02655.14 CAV20248.1 - 4.2e-06 26.9 0.0 8.6e-06 25.9 0.0 1.5 1 1 0 1 1 1 1 ATP-grasp domain CPSase_L_D2 PF02786.17 CAV20248.1 - 2e-05 24.2 0.0 3.2e-05 23.5 0.0 1.4 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain ATP-grasp PF02222.22 CAV20248.1 - 0.00039 20.1 0.0 0.00072 19.2 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp domain ATP-grasp_4 PF13535.6 CAV20248.1 - 0.024 14.2 0.0 0.049 13.2 0.0 1.5 1 0 0 1 1 1 0 ATP-grasp domain Dala_Dala_lig_C PF07478.13 CAV20248.1 - 0.12 11.9 0.1 0.2 11.1 0.1 1.4 1 0 0 1 1 1 0 D-ala D-ala ligase C-terminus RimK PF08443.11 CAV20248.1 - 0.18 11.3 0.0 0.32 10.6 0.0 1.4 1 0 0 1 1 1 0 RimK-like ATP-grasp domain DUF1481 PF07356.12 CAV20249.1 - 6.9e-59 198.8 0.5 7.9e-59 198.6 0.5 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1481) Bac_DNA_binding PF00216.21 CAV20250.1 - 1.9e-32 111.3 0.1 2.2e-32 111.1 0.1 1.1 1 0 0 1 1 1 1 Bacterial DNA-binding protein HU-HIG PF18291.1 CAV20250.1 - 5.9e-09 36.1 0.0 6.9e-09 35.9 0.0 1.1 1 0 0 1 1 1 1 HU domain fused to wHTH, Ig, or Glycine-rich motif HU-CCDC81_bac_2 PF18175.1 CAV20250.1 - 4.9e-05 23.1 0.0 7.3e-05 22.6 0.0 1.2 1 0 0 1 1 1 1 CCDC81-like prokaryotic HU domain 2 HU-CCDC81_euk_2 PF18289.1 CAV20250.1 - 0.0033 17.6 0.0 0.0057 16.8 0.0 1.3 1 0 0 1 1 1 1 CCDC81 eukaryotic HU domain 2 DUF21 PF01595.20 CAV20251.1 - 1.8e-29 102.7 1.3 2.8e-29 102.1 1.3 1.3 1 0 0 1 1 1 1 Cyclin M transmembrane N-terminal domain CBS PF00571.28 CAV20251.1 - 7.1e-10 39.2 0.1 1.3e-06 28.7 0.0 2.5 2 0 0 2 2 2 2 CBS domain DUF416 PF04222.12 CAV20252.1 - 4e-76 254.6 0.9 4.5e-76 254.5 0.9 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF416) ACC_central PF08326.12 CAV20252.1 - 0.0067 14.7 0.1 0.013 13.7 0.0 1.4 2 0 0 2 2 2 1 Acetyl-CoA carboxylase, central region 2-Hacid_dh_C PF02826.19 CAV20253.1 - 3.8e-48 163.2 0.0 4.8e-48 162.9 0.0 1.1 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain IlvN PF07991.12 CAV20253.1 - 4.1e-06 26.4 0.0 6e-06 25.9 0.0 1.2 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain Shikimate_DH PF01488.20 CAV20253.1 - 0.00033 20.7 0.0 0.00062 19.8 0.0 1.4 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase ThiF PF00899.21 CAV20253.1 - 0.00058 19.3 0.0 0.0085 15.5 0.0 2.2 2 0 0 2 2 2 1 ThiF family NAD_binding_2 PF03446.15 CAV20253.1 - 0.00058 20.1 0.0 0.00077 19.7 0.0 1.2 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase F420_oxidored PF03807.17 CAV20253.1 - 0.00079 20.0 0.1 0.0021 18.6 0.1 1.7 2 0 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent NAD_binding_7 PF13241.6 CAV20253.1 - 0.0045 17.4 0.0 0.0088 16.5 0.0 1.5 1 0 0 1 1 1 1 Putative NAD(P)-binding Pyr_redox_2 PF07992.14 CAV20253.1 - 0.019 14.2 0.0 0.025 13.8 0.0 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase AdoHcyase_NAD PF00670.21 CAV20253.1 - 0.021 14.9 0.0 0.032 14.3 0.0 1.2 1 0 0 1 1 1 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain NAD_binding_10 PF13460.6 CAV20253.1 - 0.054 13.4 0.0 0.098 12.5 0.0 1.4 1 0 0 1 1 1 0 NAD(P)H-binding THEG PF14912.6 CAV20253.1 - 0.11 13.0 0.0 0.26 11.8 0.0 1.6 1 0 0 1 1 1 0 Testicular haploid expressed repeat Nuc_deoxyri_tr3 PF11071.8 CAV20253.1 - 0.14 12.3 0.0 10 6.2 0.0 2.3 2 0 0 2 2 2 0 Nucleoside 2-deoxyribosyltransferase YtoQ UDG PF03167.19 CAV20254.1 - 4.1e-26 91.8 0.0 4.9e-26 91.6 0.0 1.1 1 0 0 1 1 1 1 Uracil DNA glycosylase superfamily URO-D PF01208.17 CAV20255.1 - 1.8e-140 468.0 0.0 2e-140 467.9 0.0 1.0 1 0 0 1 1 1 1 Uroporphyrinogen decarboxylase (URO-D) NUDIX PF00293.28 CAV20256.1 - 1.1e-19 70.8 0.0 2.6e-19 69.6 0.0 1.6 2 0 0 2 2 2 1 NUDIX domain zf-NADH-PPase PF09297.11 CAV20256.1 - 5.2e-10 38.8 5.3 8.4e-10 38.1 5.3 1.4 1 0 0 1 1 1 1 NADH pyrophosphatase zinc ribbon domain DZR PF12773.7 CAV20256.1 - 0.055 13.5 0.5 0.15 12.1 0.5 1.7 1 0 0 1 1 1 0 Double zinc ribbon DUF1451 PF07295.11 CAV20256.1 - 0.11 12.5 0.9 0.22 11.6 0.9 1.4 1 0 0 1 1 1 0 Zinc-ribbon containing domain DUF35_N PF12172.8 CAV20256.1 - 0.12 12.3 6.6 0.53 10.2 1.1 2.4 2 0 0 2 2 2 0 Rubredoxin-like zinc ribbon domain (DUF35_N) NRDD PF13597.6 CAV20256.1 - 0.14 10.9 0.4 0.2 10.4 0.4 1.2 1 0 0 1 1 1 0 Anaerobic ribonucleoside-triphosphate reductase Nudix_N_2 PF14803.6 CAV20256.1 - 0.15 12.0 5.7 1.1 9.2 5.7 2.3 1 1 0 1 1 1 0 Nudix N-terminal Rsd_AlgQ PF04353.13 CAV20257.1 - 1.4e-54 184.2 0.0 1.5e-54 184.0 0.0 1.0 1 0 0 1 1 1 1 Regulator of RNA polymerase sigma(70) subunit, Rsd/AlgQ RNA_pol_Rpb1_1 PF04997.12 CAV20258.1 - 1e-89 300.9 0.0 1.8e-89 300.2 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_5 PF04998.17 CAV20258.1 - 1e-77 261.2 0.5 2e-77 260.2 0.5 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_2 PF00623.20 CAV20258.1 - 3.7e-38 131.4 0.0 1.1e-27 97.2 0.0 2.8 1 1 1 2 2 2 2 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_3 PF04983.18 CAV20258.1 - 3e-27 95.5 0.0 7.2e-27 94.2 0.0 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_4 PF05000.17 CAV20258.1 - 4.4e-19 68.4 0.3 4.4e-19 68.4 0.3 1.9 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 4 Peptidase_M23 PF01551.22 CAV20258.1 - 0.0014 18.8 0.2 0.021 15.0 0.0 3.0 2 1 1 3 3 3 1 Peptidase family M23 Apocytochr_F_C PF01333.19 CAV20258.1 - 0.0032 17.5 0.3 0.029 14.4 0.0 2.4 2 0 0 2 2 2 1 Apocytochrome F, C-terminal DUF3150 PF11348.8 CAV20258.1 - 0.076 12.2 0.1 0.17 11.0 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3150) RNA_pol_Rpb2_6 PF00562.28 CAV20259.1 - 4e-157 523.3 0.9 1.2e-155 518.4 0.2 3.0 3 0 0 3 3 3 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.15 CAV20259.1 - 1.3e-57 194.6 0.0 3.1e-57 193.4 0.0 1.7 1 1 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_3 PF04565.16 CAV20259.1 - 2.3e-29 101.3 0.0 4.6e-29 100.4 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_2 PF04561.14 CAV20259.1 - 2.7e-28 98.9 0.3 3.2e-17 62.8 0.0 3.1 3 0 0 3 3 3 2 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_7 PF04560.20 CAV20259.1 - 9.8e-28 96.4 0.2 3.3e-27 94.7 0.1 2.0 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_45 PF10385.9 CAV20259.1 - 5.2e-23 81.1 0.6 3.8e-22 78.3 0.2 2.7 3 0 0 3 3 3 1 RNA polymerase beta subunit external 1 domain Ribosomal_L12 PF00542.19 CAV20260.1 - 2.8e-30 104.5 5.9 2.8e-30 104.5 5.9 2.0 2 0 0 2 2 2 1 Ribosomal protein L7/L12 C-terminal domain Ribosomal_L12_N PF16320.5 CAV20260.1 - 1.3e-14 53.6 14.4 1.3e-14 53.6 14.4 2.6 1 1 3 4 4 4 1 Ribosomal protein L7/L12 dimerisation domain SBP_bac_5 PF00496.22 CAV20260.1 - 0.029 13.3 0.9 2.8 6.8 0.1 2.0 1 1 1 2 2 2 0 Bacterial extracellular solute-binding proteins, family 5 Middle Ribosomal_L10 PF00466.20 CAV20261.1 - 3.3e-27 94.6 0.0 4.7e-27 94.1 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L10 Ribosomal_L1 PF00687.21 CAV20263.1 - 2.5e-52 177.6 0.1 3.3e-52 177.2 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family Ribosomal_L11_N PF03946.14 CAV20264.1 - 1.4e-31 108.1 0.2 2.3e-31 107.4 0.2 1.4 1 0 0 1 1 1 1 Ribosomal protein L11, N-terminal domain Ribosomal_L11 PF00298.19 CAV20264.1 - 5.7e-25 87.6 2.0 5.7e-25 87.6 2.0 1.6 2 0 0 2 2 2 1 Ribosomal protein L11, RNA binding domain DUF3140 PF11338.8 CAV20264.1 - 0.004 17.6 0.1 0.029 14.8 0.1 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF3140) AAA_lid_3 PF17862.1 CAV20264.1 - 0.12 12.3 0.1 0.24 11.2 0.1 1.5 1 0 0 1 1 1 0 AAA+ lid domain NusG PF02357.19 CAV20265.1 - 3.5e-26 91.5 0.0 5.1e-26 91.0 0.0 1.2 1 0 0 1 1 1 1 Transcription termination factor nusG KOW PF00467.29 CAV20265.1 - 8e-08 32.0 0.1 2.5e-07 30.4 0.2 1.8 2 0 0 2 2 2 1 KOW motif PIF1 PF05970.14 CAV20266.1 - 0.047 12.9 0.1 0.047 12.9 0.1 1.1 1 0 0 1 1 1 0 PIF1-like helicase GTP_EFTU PF00009.27 CAV20267.1 - 5.5e-58 195.7 0.0 7.3e-58 195.3 0.0 1.1 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 CAV20267.1 - 1.8e-33 115.2 0.0 3.8e-33 114.2 0.0 1.6 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 CAV20267.1 - 2.7e-17 62.9 4.6 7.1e-17 61.6 4.6 1.8 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 CAV20267.1 - 0.00021 21.4 0.0 0.00035 20.6 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase cobW PF02492.19 CAV20267.1 - 0.11 12.1 0.0 0.38 10.3 0.0 1.8 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain PRK PF00485.18 CAV20268.1 - 2.4e-11 43.8 0.0 4.9e-11 42.7 0.0 1.5 2 0 0 2 2 2 1 Phosphoribulokinase / Uridine kinase family AAA_18 PF13238.6 CAV20268.1 - 0.048 14.2 0.0 0.082 13.4 0.0 1.6 1 1 0 1 1 1 0 AAA domain CoaE PF01121.20 CAV20268.1 - 0.11 12.1 0.1 0.19 11.4 0.1 1.3 1 0 0 1 1 1 0 Dephospho-CoA kinase AAA_22 PF13401.6 CAV20268.1 - 0.16 12.2 0.0 0.28 11.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain BPL_LplA_LipB PF03099.19 CAV20269.1 - 7.6e-21 74.4 0.0 1.2e-20 73.8 0.0 1.3 1 0 0 1 1 1 1 Biotin/lipoate A/B protein ligase family BPL_C PF02237.17 CAV20269.1 - 1.5e-12 47.2 1.2 2.8e-12 46.3 1.2 1.5 1 0 0 1 1 1 1 Biotin protein ligase C terminal domain HTH_11 PF08279.12 CAV20269.1 - 6.1e-12 45.3 0.0 1.6e-11 43.9 0.0 1.8 2 0 0 2 2 2 1 HTH domain BPL_LplA_LipB_2 PF16917.5 CAV20269.1 - 0.00051 19.6 0.1 0.00077 19.0 0.1 1.2 1 0 0 1 1 1 1 Biotin/lipoate A/B protein ligase family MarR PF01047.22 CAV20269.1 - 0.073 13.0 0.0 0.15 12.0 0.0 1.5 1 0 0 1 1 1 0 MarR family HTH_5 PF01022.20 CAV20269.1 - 0.08 12.8 0.0 0.17 11.8 0.0 1.6 1 0 0 1 1 1 0 Bacterial regulatory protein, arsR family Mga PF05043.13 CAV20269.1 - 0.13 12.9 0.0 0.23 12.1 0.0 1.4 1 0 0 1 1 1 0 Mga helix-turn-helix domain MurB_C PF02873.16 CAV20270.1 - 2.4e-34 118.0 0.0 3.6e-34 117.4 0.0 1.3 1 0 0 1 1 1 1 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain FAD_binding_4 PF01565.23 CAV20270.1 - 5.3e-17 61.9 0.0 8.1e-17 61.3 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain Acetyltransf_7 PF13508.7 CAV20271.1 - 5.4e-09 36.4 0.0 9.4e-09 35.6 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 CAV20271.1 - 7.8e-09 35.5 0.0 1e-08 35.2 0.0 1.3 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 CAV20271.1 - 1.6e-07 31.6 0.0 2e-07 31.2 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_CG PF14542.6 CAV20271.1 - 0.00066 19.8 0.0 0.0011 19.0 0.0 1.3 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase FR47 PF08445.10 CAV20271.1 - 0.02 14.9 0.0 0.029 14.4 0.0 1.2 1 0 0 1 1 1 0 FR47-like protein PLDc_2 PF13091.6 CAV20272.1 - 5e-34 117.1 0.1 1.7e-25 89.4 0.0 2.4 2 0 0 2 2 2 2 PLD-like domain PLDc PF00614.22 CAV20272.1 - 1.6e-11 43.9 1.2 4.2e-05 23.5 0.0 2.5 2 0 0 2 2 2 2 Phospholipase D Active site motif Regulator_TrmB PF11495.8 CAV20272.1 - 3.7e-05 23.0 0.0 8.9e-05 21.8 0.0 1.5 1 0 0 1 1 1 1 Archaeal transcriptional regulator TrmB E1_UFD PF09358.10 CAV20272.1 - 0.15 12.8 0.5 6.6 7.5 0.3 2.7 3 0 0 3 3 3 0 Ubiquitin fold domain DDE_3 PF13358.6 CAV20273.1 - 3.7e-16 59.2 0.1 8e-16 58.1 0.0 1.5 2 0 0 2 2 2 1 DDE superfamily endonuclease PBSX_XtrA PF17356.2 CAV20273.1 - 0.15 12.0 0.0 0.24 11.3 0.0 1.3 1 0 0 1 1 1 0 Phage-like element PBSX protein XtrA PcF PF09461.10 CAV20273.1 - 0.22 11.9 0.0 0.42 11.0 0.0 1.5 1 0 0 1 1 1 0 Phytotoxin PcF protein RRM_1 PF00076.22 CAV20274.1 - 3.2e-18 65.3 0.1 5.1e-18 64.7 0.1 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 CAV20274.1 - 0.00019 21.1 0.0 0.00024 20.7 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Cullin_Nedd8 PF10557.9 CAV20274.1 - 0.078 13.0 0.0 3.3 7.8 0.0 2.3 2 0 0 2 2 2 0 Cullin protein neddylation domain RRM_7 PF16367.5 CAV20274.1 - 0.12 12.5 0.0 0.2 11.8 0.0 1.5 1 1 0 1 1 1 0 RNA recognition motif DUF4118 PF13493.6 CAV20274.1 - 0.35 10.7 3.8 0.57 10.0 3.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4118) Asp_Glu_race PF01177.22 CAV20275.1 - 9.5e-28 97.6 0.1 1.2e-27 97.2 0.1 1.1 1 0 0 1 1 1 1 Asp/Glu/Hydantoin racemase Nucleolin_bd PF16725.5 CAV20275.1 - 0.17 11.5 0.0 1.1 9.0 0.0 2.2 2 0 0 2 2 2 0 Nucleolin binding domain Diphthami_syn_2 PF01902.17 CAV20276.1 - 3.3e-25 88.9 0.0 4.4e-25 88.5 0.0 1.0 1 0 0 1 1 1 1 Diphthamide synthase TonB_dep_Rec PF00593.24 CAV20277.1 - 4.6e-39 135.6 26.6 6.1e-39 135.2 26.6 1.2 1 0 0 1 1 1 1 TonB dependent receptor Plug PF07715.15 CAV20277.1 - 1.2e-27 96.6 2.2 3e-27 95.3 2.2 1.7 1 0 0 1 1 1 1 TonB-dependent Receptor Plug Domain tRNA_U5-meth_tr PF05958.11 CAV20278.1 - 4.7e-190 631.1 4.7 5.4e-190 630.9 4.7 1.0 1 0 0 1 1 1 1 tRNA (Uracil-5-)-methyltransferase Methyltransf_25 PF13649.6 CAV20278.1 - 4.7e-06 27.2 0.0 1.1e-05 26.1 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 CAV20278.1 - 7.7e-05 22.3 0.0 0.00015 21.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_4 PF02390.17 CAV20278.1 - 9e-05 22.0 0.0 0.00017 21.1 0.0 1.5 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_11 PF08241.12 CAV20278.1 - 0.00036 21.1 0.0 0.00091 19.8 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Met_10 PF02475.16 CAV20278.1 - 0.00094 19.0 0.0 0.0021 17.9 0.0 1.6 1 0 0 1 1 1 1 Met-10+ like-protein Cons_hypoth95 PF03602.15 CAV20278.1 - 0.001 18.7 0.2 0.005 16.5 0.2 2.0 1 1 0 1 1 1 1 Conserved hypothetical protein 95 Methyltransf_31 PF13847.6 CAV20278.1 - 0.0011 18.8 0.1 0.0022 17.8 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_15 PF09445.10 CAV20278.1 - 0.0031 17.1 0.0 0.006 16.2 0.0 1.5 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase PrmA PF06325.13 CAV20278.1 - 0.0085 15.5 0.0 0.014 14.8 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) DREV PF05219.12 CAV20278.1 - 0.024 13.8 0.0 0.046 12.8 0.0 1.5 1 0 0 1 1 1 0 DREV methyltransferase DUF1422 PF07226.11 CAV20279.1 - 1.4e-46 157.1 0.7 1.7e-46 156.9 0.7 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1422) TetR_N PF00440.23 CAV20280.1 - 6.1e-10 38.7 0.0 1.4e-09 37.6 0.0 1.6 1 0 0 1 1 1 1 Bacterial regulatory proteins, tetR family HTH_IclR PF09339.10 CAV20280.1 - 0.013 15.3 0.1 0.062 13.1 0.0 2.2 2 1 0 2 2 2 0 IclR helix-turn-helix domain HTH_AraC PF00165.23 CAV20280.1 - 0.038 14.1 0.2 0.12 12.5 0.0 1.9 2 0 0 2 2 2 0 Bacterial regulatory helix-turn-helix proteins, AraC family HTH_24 PF13412.6 CAV20280.1 - 0.052 13.1 0.0 0.17 11.5 0.0 1.9 2 0 0 2 2 2 0 Winged helix-turn-helix DNA-binding TetR_C_15 PF17918.1 CAV20280.1 - 0.37 11.6 5.2 0.31 11.8 3.4 1.9 2 1 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain TetR_C_24 PF17932.1 CAV20280.1 - 1.1 9.6 4.6 0.98 9.7 0.2 2.6 2 1 1 3 3 3 0 Tetracyclin repressor-like, C-terminal domain Pyr_redox_2 PF07992.14 CAV20281.1 - 5.7e-60 203.0 0.0 8.4e-60 202.5 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.22 CAV20281.1 - 3.3e-30 104.6 0.6 1e-29 103.0 0.6 1.9 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.27 CAV20281.1 - 3.1e-18 66.1 2.4 2.3e-15 56.9 0.0 2.9 3 0 0 3 3 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 CAV20281.1 - 1e-09 38.1 2.3 1.6e-08 34.2 2.3 2.2 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 CAV20281.1 - 3.2e-08 33.1 0.0 9.4e-06 24.9 0.0 2.4 2 0 0 2 2 2 2 Glucose inhibited division protein A FAD_binding_2 PF00890.24 CAV20281.1 - 3.7e-08 32.9 4.3 4.8e-07 29.2 2.4 2.6 3 0 0 3 3 3 1 FAD binding domain FAD_oxidored PF12831.7 CAV20281.1 - 4.7e-07 29.5 0.1 1.3e-06 28.0 0.0 1.8 2 0 0 2 2 2 1 FAD dependent oxidoreductase Thi4 PF01946.17 CAV20281.1 - 6.6e-07 28.8 1.6 7.9e-07 28.5 0.5 1.7 2 0 0 2 2 2 1 Thi4 family NAD_binding_8 PF13450.6 CAV20281.1 - 1.9e-06 28.0 1.3 2.5e-05 24.4 0.2 2.5 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain K_oxygenase PF13434.6 CAV20281.1 - 6.1e-06 25.6 0.0 3.2e-05 23.2 0.0 1.9 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) HI0933_like PF03486.14 CAV20281.1 - 1.3e-05 24.1 1.7 0.0048 15.7 1.7 3.0 3 0 0 3 3 3 1 HI0933-like protein FAD_binding_3 PF01494.19 CAV20281.1 - 9.6e-05 21.8 1.1 0.00084 18.7 0.7 2.4 3 0 0 3 3 3 1 FAD binding domain AlaDh_PNT_C PF01262.21 CAV20281.1 - 0.0018 17.6 0.1 0.084 12.2 0.0 2.5 3 0 0 3 3 3 1 Alanine dehydrogenase/PNT, C-terminal domain DAO PF01266.24 CAV20281.1 - 0.0042 16.7 2.1 0.0042 16.7 2.1 2.6 4 0 0 4 4 4 1 FAD dependent oxidoreductase 3HCDH_N PF02737.18 CAV20281.1 - 0.012 15.5 0.8 6.1 6.7 1.4 2.5 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Lycopene_cycl PF05834.12 CAV20281.1 - 0.016 14.3 1.5 0.52 9.3 0.3 2.7 3 0 0 3 3 3 0 Lycopene cyclase protein ThiF PF00899.21 CAV20281.1 - 0.17 11.3 0.3 0.57 9.5 0.0 1.9 2 0 0 2 2 2 0 ThiF family MatE PF01554.18 CAV20282.1 - 8.7e-40 136.0 37.8 3.7e-25 88.5 9.9 2.5 3 0 0 3 3 3 2 MatE Polysacc_synt_C PF14667.6 CAV20282.1 - 2.6e-06 27.6 2.8 2.6e-06 27.6 2.8 4.6 3 2 0 3 3 3 1 Polysaccharide biosynthesis C-terminal domain LCM PF04072.14 CAV20283.1 - 7.7e-08 32.5 0.0 1.7e-07 31.4 0.0 1.6 1 1 0 1 1 1 1 Leucine carboxyl methyltransferase URO-D PF01208.17 CAV20283.1 - 0.11 11.7 0.0 0.15 11.2 0.0 1.2 1 0 0 1 1 1 0 Uroporphyrinogen decarboxylase (URO-D) LexA_DNA_bind PF01726.16 CAV20284.1 - 6.4e-29 99.5 0.3 3.2e-28 97.3 0.1 2.0 2 0 0 2 2 2 1 LexA DNA binding domain Peptidase_S24 PF00717.23 CAV20284.1 - 9.6e-16 57.5 0.3 1.4e-15 57.0 0.3 1.3 1 0 0 1 1 1 1 Peptidase S24-like HTH_20 PF12840.7 CAV20284.1 - 0.012 15.7 0.0 0.022 14.8 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain Sigma70_r4 PF04545.16 CAV20284.1 - 0.024 14.1 0.0 0.15 11.6 0.0 2.1 2 0 0 2 2 2 0 Sigma-70, region 4 DAGK_prokar PF01219.19 CAV20285.1 - 5.9e-36 122.4 4.3 7.3e-36 122.1 4.3 1.1 1 0 0 1 1 1 1 Prokaryotic diacylglycerol kinase ABC2_membrane_5 PF13346.6 CAV20285.1 - 0.0065 16.1 1.5 0.0065 16.0 1.5 1.1 1 0 0 1 1 1 1 ABC-2 family transporter protein DUF2976 PF11190.8 CAV20285.1 - 5.4 6.9 8.8 9.6 6.1 1.6 2.7 2 1 1 3 3 3 0 Protein of unknown function (DUF2976) Ribosomal_S27 PF01599.19 CAV20286.1 - 0.066 13.4 0.0 0.097 12.9 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein S27a Acyltransferase PF01553.21 CAV20287.1 - 4.7e-24 84.5 0.0 9.6e-24 83.5 0.0 1.5 1 0 0 1 1 1 1 Acyltransferase rve PF00665.26 CAV20288.1 - 1.4e-26 93.0 0.2 6.2e-26 90.9 0.0 1.9 2 0 0 2 2 2 1 Integrase core domain rve_3 PF13683.6 CAV20288.1 - 2.6e-19 68.7 0.0 5.3e-19 67.8 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain DDE_Tnp_IS240 PF13610.6 CAV20288.1 - 9.5e-05 22.6 0.2 0.00018 21.7 0.2 1.5 1 0 0 1 1 1 1 DDE domain HTH_21 PF13276.6 CAV20288.1 - 0.017 15.3 1.7 0.046 13.9 1.0 2.1 2 0 0 2 2 2 0 HTH-like domain rve_2 PF13333.6 CAV20288.1 - 0.052 13.7 0.1 0.1 12.8 0.1 1.5 1 0 0 1 1 1 0 Integrase core domain Thg1 PF04446.12 CAV20288.1 - 0.12 12.5 0.1 0.75 9.8 0.0 2.2 3 0 0 3 3 3 0 tRNAHis guanylyltransferase HTH_28 PF13518.6 CAV20289.1 - 9.3e-06 25.7 0.1 2.1e-05 24.6 0.1 1.6 1 0 0 1 1 1 1 Helix-turn-helix domain Sugarporin_N PF11471.8 CAV20289.1 - 0.0042 17.0 2.1 0.0082 16.1 2.1 1.5 1 0 0 1 1 1 1 Maltoporin periplasmic N-terminal extension HTH_Tnp_1 PF01527.20 CAV20289.1 - 0.088 13.1 3.0 0.32 11.3 3.0 1.9 1 1 0 1 1 1 0 Transposase UbiA PF01040.18 CAV20290.1 - 1.8e-68 230.6 16.4 2.2e-68 230.3 16.4 1.1 1 0 0 1 1 1 1 UbiA prenyltransferase family PRA1 PF03208.19 CAV20290.1 - 0.6 9.7 12.1 0.11 12.1 1.9 2.6 2 1 1 3 3 3 0 PRA1 family protein Chor_lyase PF04345.13 CAV20291.1 - 3.5e-56 189.5 0.2 4e-56 189.3 0.2 1.0 1 0 0 1 1 1 1 Chorismate lyase DUF3103 PF11301.8 CAV20291.1 - 0.17 10.7 0.0 0.21 10.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3103) FliL PF03748.14 CAV20292.1 - 1.9e-19 70.2 0.1 2.6e-19 69.7 0.1 1.2 1 0 0 1 1 1 1 Flagellar basal body-associated protein FliL Rhomboid_N PF12122.8 CAV20293.1 - 3.1e-32 110.6 0.2 4.6e-32 110.0 0.2 1.3 1 0 0 1 1 1 1 Cytoplasmic N-terminal domain of rhomboid serine protease Rhomboid PF01694.22 CAV20293.1 - 6.5e-31 107.4 14.0 6.5e-31 107.4 14.0 1.5 2 0 0 2 2 2 1 Rhomboid family Rhodanese PF00581.20 CAV20294.1 - 5.7e-09 36.4 0.0 9.7e-09 35.7 0.0 1.4 1 1 0 1 1 1 1 Rhodanese-like domain Sigma70_r2 PF04542.14 CAV20295.1 - 3.1e-17 62.1 0.0 7.6e-17 60.8 0.0 1.7 1 0 0 1 1 1 1 Sigma-70 region 2 Sigma70_r4 PF04545.16 CAV20295.1 - 1.2e-15 56.7 0.8 1.6e-14 53.1 0.1 2.3 2 0 0 2 2 2 1 Sigma-70, region 4 Sigma70_r1_2 PF00140.20 CAV20295.1 - 1.8e-06 27.8 0.1 3.7e-06 26.8 0.1 1.5 1 0 0 1 1 1 1 Sigma-70 factor, region 1.2 HTH_25 PF13413.6 CAV20295.1 - 0.014 15.2 0.2 0.4 10.6 0.1 2.3 2 0 0 2 2 2 0 Helix-turn-helix domain UCR_14kD PF02271.16 CAV20295.1 - 0.023 14.6 0.0 0.21 11.6 0.0 2.5 1 1 1 2 2 2 0 Ubiquinol-cytochrome C reductase complex 14kD subunit Sigma70_r3 PF04539.16 CAV20295.1 - 0.071 13.2 0.3 7.6 6.7 0.1 2.7 2 0 0 2 2 2 0 Sigma-70 region 3 FtsX_ECD PF18075.1 CAV20297.1 - 4.9e-10 39.9 0.1 8.7e-10 39.1 0.1 1.4 1 0 0 1 1 1 1 FtsX extracellular domain FtsX PF02687.21 CAV20297.1 - 0.00041 20.8 2.6 0.00041 20.8 2.6 3.3 3 1 0 3 3 3 1 FtsX-like permease family MPS-4 PF17523.2 CAV20297.1 - 0.7 10.1 2.1 0.97 9.6 0.6 2.0 2 0 0 2 2 2 0 MinK-related peptide, potassium channel accessory sub-unit protein 4 DUF4083 PF13314.6 CAV20297.1 - 4.7 7.2 6.0 0.48 10.4 0.6 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4083) ABC_tran PF00005.27 CAV20298.1 - 1.6e-35 122.6 0.0 2e-35 122.3 0.0 1.1 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 CAV20298.1 - 1.3e-08 35.1 0.4 7.6e-06 25.9 0.0 2.2 1 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_16 PF13191.6 CAV20298.1 - 9.5e-05 22.8 0.0 0.00016 22.1 0.0 1.3 1 1 0 1 1 1 1 AAA ATPase domain RsgA_GTPase PF03193.16 CAV20298.1 - 0.00023 21.1 0.0 0.00065 19.6 0.0 1.6 2 0 0 2 2 2 1 RsgA GTPase AAA_29 PF13555.6 CAV20298.1 - 0.00027 20.6 0.0 0.00052 19.7 0.0 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_25 PF13481.6 CAV20298.1 - 0.0058 16.2 0.0 0.047 13.3 0.0 2.2 2 1 0 2 2 2 1 AAA domain AAA_33 PF13671.6 CAV20298.1 - 0.0079 16.4 0.1 0.59 10.3 0.1 2.1 2 0 0 2 2 2 1 AAA domain AAA_23 PF13476.6 CAV20298.1 - 0.0084 16.6 0.0 0.014 15.9 0.0 1.3 1 0 0 1 1 1 1 AAA domain SMC_N PF02463.19 CAV20298.1 - 0.019 14.4 0.0 0.41 10.0 0.0 2.0 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain Zeta_toxin PF06414.12 CAV20298.1 - 0.02 14.2 0.0 0.029 13.7 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin AAA_30 PF13604.6 CAV20298.1 - 0.11 12.1 0.0 0.29 10.8 0.0 1.6 2 0 0 2 2 2 0 AAA domain cobW PF02492.19 CAV20298.1 - 0.15 11.6 0.0 0.3 10.7 0.0 1.5 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain CbiA PF01656.23 CAV20298.1 - 0.17 12.0 0.0 0.44 10.6 0.0 1.9 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain SRP54 PF00448.22 CAV20299.1 - 1.2e-77 260.0 1.5 1.2e-77 260.0 1.5 2.0 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain SRP54_N PF02881.19 CAV20299.1 - 2.1e-14 53.5 1.0 6.5e-14 51.9 0.2 2.3 2 0 0 2 2 2 1 SRP54-type protein, helical bundle domain Zeta_toxin PF06414.12 CAV20299.1 - 2.6e-08 33.4 0.2 5.4e-08 32.4 0.2 1.4 1 0 0 1 1 1 1 Zeta toxin AAA_22 PF13401.6 CAV20299.1 - 1.2e-06 28.9 0.9 2.1e-05 24.8 0.0 2.6 2 1 0 2 2 2 1 AAA domain AAA_30 PF13604.6 CAV20299.1 - 3.2e-06 27.0 1.2 7.3e-06 25.8 1.2 1.6 1 0 0 1 1 1 1 AAA domain MeaB PF03308.16 CAV20299.1 - 6.8e-05 22.0 0.7 0.0024 16.9 0.1 2.4 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_24 PF13479.6 CAV20299.1 - 9.6e-05 22.2 0.2 0.08 12.7 0.1 2.6 2 1 0 2 2 2 2 AAA domain AAA_33 PF13671.6 CAV20299.1 - 0.00013 22.1 1.2 0.00023 21.4 0.1 2.0 2 0 0 2 2 2 1 AAA domain AAA_17 PF13207.6 CAV20299.1 - 0.00067 20.1 0.2 0.00067 20.1 0.2 3.0 2 1 2 4 4 4 1 AAA domain AAA_31 PF13614.6 CAV20299.1 - 0.00079 19.4 1.8 0.00099 19.1 0.2 1.9 2 0 0 2 2 2 1 AAA domain APS_kinase PF01583.20 CAV20299.1 - 0.0017 18.3 0.0 0.0057 16.6 0.0 1.9 1 0 0 1 1 1 1 Adenylylsulphate kinase AAA_16 PF13191.6 CAV20299.1 - 0.0024 18.3 0.0 0.0024 18.3 0.0 2.7 1 1 1 2 2 1 1 AAA ATPase domain CbiA PF01656.23 CAV20299.1 - 0.0034 17.4 0.6 0.015 15.4 0.1 2.3 2 1 0 2 2 2 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA PF00004.29 CAV20299.1 - 0.0035 17.8 0.1 0.011 16.2 0.1 1.9 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) ABC_tran PF00005.27 CAV20299.1 - 0.0099 16.4 0.1 0.0099 16.4 0.1 2.5 2 1 0 2 2 1 1 ABC transporter Thymidylate_kin PF02223.17 CAV20299.1 - 0.016 14.9 0.0 0.016 14.9 0.0 2.6 2 0 0 2 2 2 0 Thymidylate kinase VirC1 PF07015.11 CAV20299.1 - 0.017 14.5 0.0 0.029 13.7 0.0 1.3 1 0 0 1 1 1 0 VirC1 protein DUF2075 PF09848.9 CAV20299.1 - 0.019 14.2 0.1 0.019 14.2 0.1 1.5 2 0 0 2 2 1 0 Uncharacterized conserved protein (DUF2075) MMR_HSR1 PF01926.23 CAV20299.1 - 0.022 14.8 0.5 0.1 12.7 0.5 2.2 1 1 0 1 1 1 0 50S ribosome-binding GTPase NTPase_1 PF03266.15 CAV20299.1 - 0.037 14.0 3.1 0.34 10.8 0.8 2.5 1 1 0 2 2 2 0 NTPase AAA_7 PF12775.7 CAV20299.1 - 0.08 12.5 0.1 0.2 11.2 0.1 1.6 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_19 PF13245.6 CAV20299.1 - 0.099 13.0 0.7 0.24 11.8 0.7 1.7 1 1 0 1 1 1 0 AAA domain Ploopntkinase3 PF18751.1 CAV20299.1 - 0.1 12.5 0.3 0.27 11.1 0.3 1.7 1 1 0 1 1 1 0 P-loop Nucleotide Kinase3 AAA_18 PF13238.6 CAV20299.1 - 0.1 13.1 0.8 0.26 11.8 0.0 2.1 2 1 0 2 2 1 0 AAA domain MobB PF03205.14 CAV20299.1 - 0.11 12.4 1.1 0.18 11.7 0.2 1.9 2 0 0 2 2 1 0 Molybdopterin guanine dinucleotide synthesis protein B DUF2855 PF11017.8 CAV20299.1 - 0.48 10.1 5.4 2.3 7.9 0.0 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF2855) Hid1 PF12722.7 CAV20299.1 - 1.2 7.1 6.4 1.6 6.8 6.4 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein DUF853 PF05872.12 CAV20299.1 - 2.3 6.7 19.4 0.31 9.6 0.5 3.1 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF853) TrwB_AAD_bind PF10412.9 CAV20299.1 - 3.2 6.6 7.9 0.32 9.8 0.1 2.6 3 0 0 3 3 3 0 Type IV secretion-system coupling protein DNA-binding domain Presenilin PF01080.17 CAV20299.1 - 3.5 6.3 7.5 4.6 5.9 7.5 1.2 1 0 0 1 1 1 0 Presenilin ATP_bind_1 PF03029.17 CAV20299.1 - 5.4 6.7 6.7 0.61 9.8 0.5 2.5 3 0 0 3 3 3 0 Conserved hypothetical ATP binding protein Cons_hypoth95 PF03602.15 CAV20301.1 - 9.6e-62 207.9 0.0 1.1e-61 207.7 0.0 1.0 1 0 0 1 1 1 1 Conserved hypothetical protein 95 MTS PF05175.14 CAV20301.1 - 2.1e-09 37.1 0.0 2.7e-09 36.8 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_31 PF13847.6 CAV20301.1 - 6.1e-07 29.3 0.0 8e-07 29.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain MethyltransfD12 PF02086.15 CAV20301.1 - 5.2e-06 26.3 0.0 0.072 12.8 0.0 2.1 1 1 1 2 2 2 2 D12 class N6 adenine-specific DNA methyltransferase Methyltransf_15 PF09445.10 CAV20301.1 - 3.5e-05 23.5 0.0 4.8e-05 23.0 0.0 1.2 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase Methyltransf_25 PF13649.6 CAV20301.1 - 3.9e-05 24.3 0.0 6.1e-05 23.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.17 CAV20301.1 - 0.00015 21.3 0.1 0.00039 19.9 0.0 1.6 1 1 1 2 2 2 1 Putative methyltransferase Methyltr_RsmB-F PF01189.17 CAV20301.1 - 0.00021 21.0 0.0 0.00031 20.5 0.0 1.2 1 0 0 1 1 1 1 16S rRNA methyltransferase RsmB/F Methyltrans_SAM PF10672.9 CAV20301.1 - 0.0003 20.1 0.0 0.00042 19.6 0.0 1.1 1 0 0 1 1 1 1 S-adenosylmethionine-dependent methyltransferase GidB PF02527.15 CAV20301.1 - 0.00053 19.4 0.0 0.00078 18.8 0.0 1.2 1 0 0 1 1 1 1 rRNA small subunit methyltransferase G RrnaAD PF00398.20 CAV20301.1 - 0.00088 18.4 0.0 0.0013 17.9 0.0 1.2 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Met_10 PF02475.16 CAV20301.1 - 0.0036 17.1 0.0 0.0045 16.7 0.0 1.1 1 0 0 1 1 1 1 Met-10+ like-protein TRM PF02005.16 CAV20301.1 - 0.0066 15.7 0.0 0.0069 15.6 0.0 1.1 1 0 0 1 1 1 1 N2,N2-dimethylguanosine tRNA methyltransferase DNA_methylase PF00145.17 CAV20301.1 - 0.018 14.4 0.0 0.046 13.1 0.0 1.6 2 0 0 2 2 2 0 C-5 cytosine-specific DNA methylase Methyltransf_12 PF08242.12 CAV20301.1 - 0.028 15.1 0.0 0.061 14.1 0.0 1.6 1 1 0 1 1 1 0 Methyltransferase domain RsmJ PF04378.13 CAV20301.1 - 0.033 13.4 0.0 0.044 13.0 0.0 1.2 1 0 0 1 1 1 0 Ribosomal RNA large subunit methyltransferase D, RlmJ Methyltransf_32 PF13679.6 CAV20301.1 - 0.072 13.1 0.0 0.11 12.5 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain UPF0020 PF01170.18 CAV20301.1 - 0.095 12.4 0.1 0.43 10.2 0.1 1.9 1 1 0 1 1 1 0 Putative RNA methylase family UPF0020 N6_N4_Mtase PF01555.18 CAV20301.1 - 0.12 12.0 0.0 0.38 10.4 0.0 1.7 2 0 0 2 2 2 0 DNA methylase Methyltransf_11 PF08241.12 CAV20301.1 - 0.16 12.6 0.0 0.45 11.2 0.0 1.8 1 1 0 1 1 1 0 Methyltransferase domain DUF1145 PF06611.12 CAV20302.1 - 1.2e-17 63.6 9.3 1.2e-17 63.6 9.3 1.4 2 0 0 2 2 2 1 Protein of unknown function (DUF1145) DUF308 PF03729.13 CAV20302.1 - 0.047 14.0 8.7 0.078 13.3 8.7 1.4 1 1 0 1 1 1 0 Short repeat of unknown function (DUF308) Sdh_cyt PF01127.22 CAV20302.1 - 0.19 11.8 4.8 0.29 11.2 4.8 1.3 1 1 0 1 1 1 0 Succinate dehydrogenase/Fumarate reductase transmembrane subunit MarC PF01914.17 CAV20303.1 - 4.8e-54 182.8 19.7 5.5e-54 182.6 19.7 1.0 1 0 0 1 1 1 1 MarC family integral membrane protein TerC PF03741.16 CAV20303.1 - 3.8e-05 23.4 3.2 3.8e-05 23.4 3.2 2.4 1 1 0 2 2 2 1 Integral membrane protein TerC family LtrA PF06772.11 CAV20303.1 - 0.077 12.2 8.3 0.022 14.0 4.0 1.9 1 1 1 2 2 2 0 Bacterial low temperature requirement A protein (LtrA) DUF2492 PF10678.9 CAV20304.1 - 3.9e-27 94.3 0.4 4.4e-27 94.2 0.4 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2492) YhhN PF07947.14 CAV20305.1 - 9.7e-34 116.6 27.9 1.2e-33 116.3 27.9 1.1 1 0 0 1 1 1 1 YhhN family DUF2500 PF10694.9 CAV20307.1 - 3.3e-25 88.7 0.0 3.9e-25 88.5 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2500) Acyl_transf_3 PF01757.22 CAV20308.1 - 1.2e-28 100.1 39.3 1.4e-28 100.0 39.3 1.0 1 0 0 1 1 1 1 Acyltransferase family MFS_1 PF07690.16 CAV20309.1 - 1.1e-20 73.9 49.6 2.4e-18 66.2 37.3 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.7 CAV20309.1 - 0.0032 16.4 8.6 0.0032 16.4 8.6 2.4 1 1 1 2 2 2 1 MFS_1 like family DSPc PF00782.20 CAV20310.1 - 3.8e-08 33.2 0.0 5e-08 32.8 0.0 1.1 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain CDKN3 PF05706.12 CAV20310.1 - 7.2e-06 25.8 0.0 9.2e-06 25.4 0.0 1.1 1 0 0 1 1 1 1 Cyclin-dependent kinase inhibitor 3 (CDKN3) Y_phosphatase PF00102.27 CAV20310.1 - 3e-05 23.7 0.0 3.4e-05 23.5 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.6 CAV20310.1 - 3.2e-05 24.0 0.1 4e-05 23.7 0.1 1.3 1 1 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase2 PF03162.13 CAV20310.1 - 0.017 14.7 0.0 0.02 14.5 0.0 1.2 1 0 0 1 1 1 0 Tyrosine phosphatase family Gp_dh_C PF02800.20 CAV20311.1 - 7.9e-60 201.0 0.1 1.5e-59 200.1 0.1 1.4 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain Gp_dh_N PF00044.24 CAV20311.1 - 7.6e-34 116.1 4.7 3.6e-33 113.9 0.4 2.7 3 1 0 3 3 3 1 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain DapB_N PF01113.20 CAV20311.1 - 0.0041 17.2 0.7 0.11 12.7 0.1 3.0 3 1 0 3 3 3 1 Dihydrodipicolinate reductase, N-terminus NAD_binding_3 PF03447.16 CAV20311.1 - 0.022 15.4 0.1 0.047 14.3 0.1 1.7 1 1 0 1 1 1 0 Homoserine dehydrogenase, NAD binding domain Semialdhyde_dhC PF02774.18 CAV20311.1 - 0.025 14.7 0.0 0.043 13.9 0.0 1.4 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, dimerisation domain PriA_3primeBD PF17764.1 CAV20311.1 - 0.031 14.2 0.4 0.21 11.5 0.0 2.4 2 2 0 2 2 2 0 3′ DNA-binding domain (3′BD) Hydrolase_like PF13242.6 CAV20311.1 - 0.038 14.1 0.0 1.9 8.6 0.0 2.3 2 0 0 2 2 2 0 HAD-hyrolase-like Retinin_C PF04527.12 CAV20311.1 - 0.12 12.6 1.5 3 8.2 0.1 2.4 1 1 1 2 2 2 0 Drosophila Retinin like protein HTH_5 PF01022.20 CAV20312.1 - 5e-11 42.3 0.3 7.6e-11 41.7 0.3 1.3 1 0 0 1 1 1 1 Bacterial regulatory protein, arsR family HTH_20 PF12840.7 CAV20312.1 - 3e-10 40.0 0.1 4.7e-10 39.4 0.1 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain MarR PF01047.22 CAV20312.1 - 0.00016 21.5 0.1 0.00026 20.8 0.1 1.3 1 0 0 1 1 1 1 MarR family MarR_2 PF12802.7 CAV20312.1 - 0.00062 19.6 0.2 0.001 18.9 0.2 1.3 1 0 0 1 1 1 1 MarR family Replic_Relax PF13814.6 CAV20312.1 - 0.018 15.1 0.1 0.023 14.8 0.1 1.2 1 0 0 1 1 1 0 Replication-relaxation Rrf2 PF02082.20 CAV20312.1 - 0.04 14.3 0.0 0.058 13.7 0.0 1.2 1 0 0 1 1 1 0 Transcriptional regulator HTH_IclR PF09339.10 CAV20312.1 - 0.041 13.7 0.1 0.064 13.1 0.1 1.3 1 0 0 1 1 1 0 IclR helix-turn-helix domain TrmB PF01978.19 CAV20312.1 - 0.065 13.1 0.0 0.095 12.6 0.0 1.2 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB PCI PF01399.27 CAV20312.1 - 0.094 13.2 0.1 0.14 12.7 0.1 1.3 1 0 0 1 1 1 0 PCI domain HDOD PF08668.12 CAV20313.1 - 5.1e-13 48.9 0.0 1e-12 47.9 0.0 1.4 1 0 0 1 1 1 1 HDOD domain EAL PF00563.20 CAV20313.1 - 5.9e-13 48.9 0.2 1.9e-11 44.0 0.0 3.1 2 1 0 2 2 2 1 EAL domain DUF2863 PF11062.8 CAV20313.1 - 0.012 14.0 0.0 0.017 13.6 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2863) DprA_WH PF17782.1 CAV20313.1 - 0.064 13.4 0.7 13 6.0 0.2 2.5 2 0 0 2 2 2 0 DprA winged helix domain LysE PF01810.18 CAV20314.1 - 3.3e-35 121.3 9.5 3.9e-35 121.1 9.5 1.0 1 0 0 1 1 1 1 LysE type translocator Zip PF02535.22 CAV20314.1 - 0.026 13.7 1.8 0.046 12.9 1.8 1.4 1 0 0 1 1 1 0 ZIP Zinc transporter TerC PF03741.16 CAV20314.1 - 0.28 10.8 9.1 0.032 13.9 4.4 1.9 2 1 1 3 3 3 0 Integral membrane protein TerC family Hydrolase_4 PF12146.8 CAV20315.1 - 6.3e-56 189.3 0.0 7.6e-56 189.1 0.0 1.1 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 CAV20315.1 - 2.2e-20 73.4 0.3 2.7e-20 73.1 0.3 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CAV20315.1 - 2.5e-10 41.3 0.0 3.3e-10 40.9 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family DLH PF01738.18 CAV20315.1 - 5.9e-05 22.7 0.0 0.00013 21.6 0.0 1.5 1 0 0 1 1 1 1 Dienelactone hydrolase family LIDHydrolase PF10230.9 CAV20315.1 - 0.00085 19.0 0.0 0.0016 18.1 0.0 1.3 1 0 0 1 1 1 1 Lipid-droplet associated hydrolase Peptidase_S9 PF00326.21 CAV20315.1 - 0.0023 17.4 0.0 0.0053 16.3 0.0 1.6 1 0 0 1 1 1 1 Prolyl oligopeptidase family DUF452 PF04301.13 CAV20315.1 - 0.063 12.8 0.7 0.31 10.5 0.0 2.1 2 1 0 3 3 3 0 Protein of unknown function (DUF452) Hydrolase_3 PF08282.12 CAV20316.1 - 9.5e-65 218.9 0.0 1.1e-64 218.7 0.0 1.0 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase S6PP PF05116.13 CAV20316.1 - 6.1e-20 71.8 0.1 4.8e-10 39.4 0.0 2.1 2 0 0 2 2 2 2 Sucrose-6F-phosphate phosphohydrolase Hydrolase PF00702.26 CAV20316.1 - 5e-09 36.8 0.1 2.2e-08 34.6 0.1 1.9 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 CAV20316.1 - 0.00018 21.9 0.1 0.048 14.1 0.0 2.7 2 1 1 3 3 3 1 haloacid dehalogenase-like hydrolase Trehalose_PPase PF02358.16 CAV20316.1 - 0.045 12.9 0.0 1.6 7.8 0.0 2.1 2 0 0 2 2 2 0 Trehalose-phosphatase Hydrolase_6 PF13344.6 CAV20316.1 - 0.088 12.9 0.0 0.64 10.2 0.0 2.4 1 1 0 1 1 1 0 Haloacid dehalogenase-like hydrolase EVE PF01878.18 CAV20317.1 - 5.4e-55 185.4 0.1 6e-55 185.3 0.1 1.0 1 0 0 1 1 1 1 EVE domain NlpE_C PF17185.4 CAV20318.1 - 0.022 15.0 0.0 0.062 13.6 0.0 1.8 1 0 0 1 1 1 0 NlpE C-terminal OB domain NlpE PF04170.12 CAV20318.1 - 0.03 15.3 0.3 0.11 13.5 0.3 2.0 1 0 0 1 1 1 0 NlpE N-terminal domain DTW PF03942.15 CAV20319.1 - 5.7e-43 146.9 1.8 6.8e-43 146.7 1.8 1.0 1 0 0 1 1 1 1 DTW domain EAL PF00563.20 CAV20320.1 - 2.2e-56 191.1 0.5 3.7e-56 190.3 0.5 1.3 1 0 0 1 1 1 1 EAL domain FIST PF08495.10 CAV20320.1 - 1.4e-24 87.0 0.0 2.6e-24 86.2 0.0 1.5 1 0 0 1 1 1 1 FIST N domain FIST_C PF10442.9 CAV20320.1 - 1.4e-11 44.5 0.0 5e-11 42.7 0.0 2.0 1 0 0 1 1 1 1 FIST C domain GGDEF PF00990.21 CAV20320.1 - 4.8e-08 32.9 0.0 1.1e-07 31.7 0.0 1.7 1 0 0 1 1 1 1 Diguanylate cyclase, GGDEF domain EAL PF00563.20 CAV20321.1 - 5.1e-58 196.4 0.0 1.2e-57 195.2 0.0 1.6 2 0 0 2 2 2 1 EAL domain FIST PF08495.10 CAV20321.1 - 6.6e-20 71.8 0.0 1.2e-19 70.9 0.0 1.5 1 0 0 1 1 1 1 FIST N domain FIST_C PF10442.9 CAV20321.1 - 2.2e-13 50.3 0.0 4.9e-13 49.2 0.0 1.6 1 0 0 1 1 1 1 FIST C domain GGDEF PF00990.21 CAV20321.1 - 8.4e-08 32.1 0.4 1.6e-07 31.2 0.4 1.5 1 0 0 1 1 1 1 Diguanylate cyclase, GGDEF domain HAD_2 PF13419.6 CAV20322.1 - 3e-13 50.2 0.0 1.3e-12 48.2 0.0 1.9 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 CAV20322.1 - 9.8e-11 42.3 0.0 1.2e-10 42.0 0.0 1.1 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 CAV20322.1 - 4.9e-09 36.1 0.0 8.4e-09 35.4 0.0 1.4 1 0 0 1 1 1 1 HAD-hyrolase-like PNK3P PF08645.11 CAV20322.1 - 0.0036 17.0 0.2 0.12 12.1 0.2 2.1 1 1 0 1 1 1 1 Polynucleotide kinase 3 phosphatase PGP_phosphatase PF09419.10 CAV20322.1 - 0.0074 15.9 0.0 0.073 12.7 0.0 2.4 3 0 0 3 3 3 1 Mitochondrial PGP phosphatase Phage_integrase PF00589.22 CAV20323.1 - 2.3e-46 157.7 0.0 3.9e-46 157.0 0.0 1.4 1 0 0 1 1 1 1 Phage integrase family Phage_int_SAM_1 PF02899.17 CAV20323.1 - 6.2e-20 71.3 1.2 6.2e-20 71.3 1.2 2.6 2 1 1 3 3 3 1 Phage integrase, N-terminal SAM-like domain Phage_int_SAM_4 PF13495.6 CAV20323.1 - 2.7e-05 24.5 0.1 6.4e-05 23.3 0.1 1.6 1 0 0 1 1 1 1 Phage integrase, N-terminal SAM-like domain Phage_int_SAM_2 PF12834.7 CAV20323.1 - 0.0013 19.4 0.3 0.0089 16.7 0.0 2.3 2 1 0 2 2 2 1 Phage integrase, N-terminal MdcG PF10620.9 CAV20323.1 - 0.0056 16.5 0.1 0.012 15.4 0.1 1.5 1 1 0 1 1 1 1 Phosphoribosyl-dephospho-CoA transferase MdcG DUF3435 PF11917.8 CAV20323.1 - 0.013 14.4 0.6 0.019 13.9 0.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3435) Phage_int_SAM_5 PF13102.6 CAV20323.1 - 0.015 15.6 0.3 0.48 10.8 0.1 2.7 2 2 1 3 3 3 0 Phage integrase SAM-like domain DUF484 PF04340.12 CAV20324.1 - 3.6e-63 213.3 0.4 4.6e-63 212.9 0.4 1.1 1 0 0 1 1 1 1 Protein of unknown function, DUF484 GAF_3 PF13492.6 CAV20324.1 - 0.024 15.0 0.0 0.057 13.8 0.0 1.6 1 0 0 1 1 1 0 GAF domain ETAA1 PF15350.6 CAV20324.1 - 0.069 11.4 0.9 0.09 11.1 0.9 1.1 1 0 0 1 1 1 0 Ewing's tumour-associated antigen 1 homologue DAP_epimerase PF01678.19 CAV20325.1 - 3.1e-66 221.0 0.6 6e-33 113.6 0.0 2.0 2 0 0 2 2 2 2 Diaminopimelate epimerase Orn_Arg_deC_N PF02784.16 CAV20326.1 - 1.1e-71 241.1 0.0 1.3e-71 240.8 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, pyridoxal binding domain Orn_DAP_Arg_deC PF00278.22 CAV20326.1 - 1.7e-26 92.3 0.0 2e-26 92.0 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, C-terminal sheet domain Ala_racemase_N PF01168.20 CAV20326.1 - 1.8e-06 27.8 0.0 7.9e-06 25.7 0.0 2.0 2 1 0 2 2 2 1 Alanine racemase, N-terminal domain LPAM_2 PF13627.6 CAV20327.1 - 6.7e-09 35.3 0.3 1.1e-08 34.7 0.3 1.4 1 0 0 1 1 1 1 Prokaryotic lipoprotein-attachment site Trep_Strep PF09605.10 CAV20327.1 - 0.055 13.5 2.0 0.059 13.3 2.0 1.0 1 0 0 1 1 1 0 Hypothetical bacterial integral membrane protein (Trep_Strep) Frataxin_Cyay PF01491.16 CAV20328.1 - 3.1e-29 101.2 0.3 3.5e-29 101.0 0.3 1.0 1 0 0 1 1 1 1 Frataxin-like domain Collectrin PF16959.5 CAV20328.1 - 0.064 13.0 0.2 0.088 12.6 0.2 1.2 1 0 0 1 1 1 0 Renal amino acid transporter Adenylate_cycl PF01295.18 CAV20329.1 - 5.2e-252 837.8 1.1 6.2e-252 837.6 1.1 1.0 1 0 0 1 1 1 1 Adenylate cyclase, class-I Adenyl_cycl_N PF12633.7 CAV20329.1 - 3.9e-78 261.9 0.1 8e-78 260.9 0.0 1.6 2 0 0 2 2 2 1 Adenylate cyclase NT domain Porphobil_deam PF01379.20 CAV20330.1 - 6.6e-83 277.2 0.0 8e-83 277.0 0.0 1.1 1 0 0 1 1 1 1 Porphobilinogen deaminase, dipyromethane cofactor binding domain Porphobil_deamC PF03900.15 CAV20330.1 - 1e-19 70.6 0.0 2e-19 69.7 0.0 1.5 1 0 0 1 1 1 1 Porphobilinogen deaminase, C-terminal domain HEM4 PF02602.15 CAV20331.1 - 1.9e-30 105.9 0.0 2.1e-30 105.8 0.0 1.0 1 0 0 1 1 1 1 Uroporphyrinogen-III synthase HemD YbaJ PF10757.9 CAV20331.1 - 0.018 15.6 0.4 8 7.0 0.1 2.9 2 1 1 3 3 3 0 Biofilm formation regulator YbaJ PTH2 PF01981.16 CAV20331.1 - 0.03 14.6 0.1 3.1 8.1 0.0 2.3 2 0 0 2 2 2 0 Peptidyl-tRNA hydrolase PTH2 HemX PF04375.14 CAV20332.1 - 7.5e-100 334.5 18.0 7.5e-100 334.5 18.0 2.0 1 1 1 2 2 2 1 HemX, putative uroporphyrinogen-III C-methyltransferase VWA_2 PF13519.6 CAV20332.1 - 0.003 18.2 1.5 0.027 15.1 0.0 2.6 2 1 0 2 2 2 1 von Willebrand factor type A domain gpW PF02831.15 CAV20332.1 - 0.0044 16.9 2.9 0.013 15.4 2.9 1.7 1 0 0 1 1 1 1 gpW VirB8 PF04335.13 CAV20332.1 - 0.0053 16.6 0.7 0.013 15.3 0.7 1.7 1 0 0 1 1 1 1 VirB8 protein DUF948 PF06103.11 CAV20332.1 - 1.1 9.6 8.4 0.56 10.5 4.2 2.8 3 1 0 3 3 3 0 Bacterial protein of unknown function (DUF948) IZUMO PF15005.6 CAV20332.1 - 1.7 9.2 7.2 5.7 7.5 1.3 3.4 3 1 1 4 4 4 0 Izumo sperm-egg fusion, Ig domain-associated DUF4366 PF14283.6 CAV20332.1 - 1.7 8.7 11.0 0.053 13.6 2.1 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4366) DUF1081 PF06448.11 CAV20332.1 - 1.9 8.9 6.8 0.95 9.9 2.0 2.4 2 0 0 2 2 2 0 Domain of Unknown Function (DUF1081) Peptidase_S64 PF08192.11 CAV20332.1 - 3.3 6.1 22.8 1.3 7.5 19.5 2.0 1 1 0 1 1 1 0 Peptidase family S64 HemY_N PF07219.13 CAV20333.1 - 4.7e-28 97.5 5.5 1.2e-27 96.2 0.2 3.1 3 0 0 3 3 3 1 HemY protein N-terminus TPR_19 PF14559.6 CAV20333.1 - 9.1e-06 26.1 2.0 0.0025 18.3 0.2 3.1 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 CAV20333.1 - 1.1e-05 25.2 5.1 2.4e-05 24.1 0.5 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat ANAPC3 PF12895.7 CAV20333.1 - 2.5e-05 24.4 6.5 0.017 15.3 0.5 3.7 2 2 1 3 3 3 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 PF13176.6 CAV20333.1 - 2.8e-05 23.8 0.8 0.00016 21.5 0.2 2.6 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.6 CAV20333.1 - 3.5e-05 24.0 5.4 0.00031 21.0 3.3 3.3 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_1 PF00515.28 CAV20333.1 - 0.0004 20.1 0.5 0.0017 18.1 0.1 2.3 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.6 CAV20333.1 - 0.00063 20.4 1.2 0.061 14.2 0.7 3.7 1 1 2 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.6 CAV20333.1 - 0.0053 16.4 0.1 0.89 9.3 0.1 2.7 1 1 1 2 2 2 1 TPR repeat TPR_17 PF13431.6 CAV20333.1 - 0.0089 16.4 0.5 0.046 14.1 0.1 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat Sigma70_r1_2 PF00140.20 CAV20333.1 - 0.13 12.3 0.4 0.33 11.0 0.4 1.7 1 0 0 1 1 1 0 Sigma-70 factor, region 1.2 TPR_20 PF14561.6 CAV20333.1 - 0.18 12.1 3.2 11 6.4 0.3 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_8 PF13181.6 CAV20333.1 - 0.8 10.1 5.3 3.6 8.1 0.1 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat NAD_binding_1 PF00175.21 CAV20334.1 - 8.2e-23 81.1 0.0 1.5e-22 80.3 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain NAD_binding_6 PF08030.12 CAV20334.1 - 2.8e-05 24.3 0.0 5.8e-05 23.3 0.0 1.5 1 0 0 1 1 1 1 Ferric reductase NAD binding domain FAD_binding_6 PF00970.24 CAV20334.1 - 7.6e-05 23.0 0.0 0.00012 22.4 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain FAD_binding_8 PF08022.12 CAV20334.1 - 0.0011 19.0 0.0 0.0021 18.1 0.0 1.4 1 0 0 1 1 1 1 FAD-binding domain SIP PF04954.13 CAV20334.1 - 0.0038 17.7 0.5 0.029 14.9 0.5 2.1 1 1 0 1 1 1 1 Siderophore-interacting protein Fer2 PF00111.27 CAV20335.1 - 7.4e-14 51.5 0.1 8.2e-14 51.3 0.1 1.1 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain Fer2_4 PF13510.6 CAV20335.1 - 0.005 16.8 0.6 0.011 15.8 0.6 1.6 1 1 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain UbiD PF01977.16 CAV20336.1 - 3.1e-185 615.8 0.9 3.2e-162 540.0 0.0 2.0 2 0 0 2 2 2 2 3-octaprenyl-4-hydroxybenzoate carboxy-lyase Clathrin PF00637.20 CAV20337.1 - 0.033 14.0 0.2 0.13 12.1 0.2 2.1 1 1 1 2 2 2 0 Region in Clathrin and VPS Rho_RNA_bind PF07497.12 CAV20338.1 - 8.1e-32 108.9 0.0 1.9e-31 107.8 0.0 1.6 1 0 0 1 1 1 1 Rho termination factor, RNA-binding domain ATP-synt_ab PF00006.25 CAV20338.1 - 3.1e-21 76.0 0.0 4.3e-21 75.6 0.0 1.2 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain Rho_N PF07498.12 CAV20338.1 - 1.2e-15 57.2 0.7 4.1e-15 55.4 0.2 2.3 3 0 0 3 3 3 1 Rho termination factor, N-terminal domain NACHT PF05729.12 CAV20338.1 - 3.8e-06 26.9 0.0 7e-06 26.1 0.0 1.3 1 0 0 1 1 1 1 NACHT domain AAA_25 PF13481.6 CAV20338.1 - 0.00017 21.3 0.0 0.00063 19.4 0.0 1.8 1 1 0 1 1 1 1 AAA domain AAA PF00004.29 CAV20338.1 - 0.0033 17.8 0.0 0.0077 16.7 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 CAV20338.1 - 0.004 17.4 0.0 0.01 16.1 0.0 1.6 1 0 0 1 1 1 1 AAA domain OB_RNB PF08206.11 CAV20338.1 - 0.0053 16.4 0.0 0.011 15.4 0.0 1.5 1 0 0 1 1 1 1 Ribonuclease B OB domain Shikimate_DH PF01488.20 CAV20338.1 - 0.067 13.2 0.7 2 8.4 0.1 2.8 3 0 0 3 3 3 0 Shikimate / quinate 5-dehydrogenase DnaB_C PF03796.15 CAV20338.1 - 0.11 11.8 0.0 0.22 10.8 0.0 1.5 1 0 0 1 1 1 0 DnaB-like helicase C terminal domain Thioredoxin PF00085.20 CAV20339.1 - 3.5e-32 110.5 0.0 3.9e-32 110.3 0.0 1.0 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.6 CAV20339.1 - 5.1e-08 33.3 0.0 1.3e-06 28.8 0.0 2.0 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_8 PF13905.6 CAV20339.1 - 5e-06 26.8 0.0 0.00018 21.8 0.0 2.1 1 1 1 2 2 2 1 Thioredoxin-like TraF PF13728.6 CAV20339.1 - 0.0012 18.7 0.0 0.0015 18.4 0.0 1.2 1 0 0 1 1 1 1 F plasmid transfer operon protein Thioredoxin_9 PF14595.6 CAV20339.1 - 0.011 15.5 0.0 0.013 15.3 0.0 1.2 1 0 0 1 1 1 0 Thioredoxin AhpC-TSA PF00578.21 CAV20339.1 - 0.012 15.6 0.0 0.019 14.9 0.0 1.4 1 0 0 1 1 1 0 AhpC/TSA family Thioredoxin_7 PF13899.6 CAV20339.1 - 0.028 14.6 0.1 0.05 13.8 0.1 1.6 1 1 0 1 1 1 0 Thioredoxin-like Redoxin PF08534.10 CAV20339.1 - 0.032 14.0 0.0 0.067 12.9 0.0 1.6 1 1 1 2 2 2 0 Redoxin OST3_OST6 PF04756.13 CAV20339.1 - 0.17 11.2 0.0 0.18 11.2 0.0 1.1 1 0 0 1 1 1 0 OST3 / OST6 family, transporter family DEAD PF00270.29 CAV20340.1 - 2.5e-46 157.6 0.0 3.5e-45 153.9 0.0 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CAV20340.1 - 1.7e-31 108.8 0.0 2.6e-30 105.0 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 CAV20340.1 - 0.00015 21.8 0.0 0.00027 21.0 0.0 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 CAV20340.1 - 0.0054 16.0 0.0 0.0079 15.4 0.0 1.2 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase CMS1 PF14617.6 CAV20340.1 - 0.034 13.5 0.0 0.067 12.5 0.0 1.4 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit SNF2_N PF00176.23 CAV20340.1 - 0.035 12.8 0.0 0.058 12.1 0.0 1.2 1 0 0 1 1 1 0 SNF2 family N-terminal domain AAA_22 PF13401.6 CAV20340.1 - 0.11 12.7 0.1 0.32 11.3 0.1 1.7 1 1 0 1 1 1 0 AAA domain DUF2075 PF09848.9 CAV20340.1 - 0.16 11.2 0.0 0.25 10.5 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) Ppx-GppA PF02541.16 CAV20341.1 - 2.4e-86 289.7 1.7 4.3e-86 288.9 1.7 1.4 1 0 0 1 1 1 1 Ppx/GppA phosphatase family FtsA PF14450.6 CAV20341.1 - 0.024 15.0 0.1 0.23 11.9 0.1 2.5 2 1 0 2 2 2 0 Cell division protein FtsA Vut_1 PF02592.15 CAV20342.1 - 6e-38 130.5 11.0 6e-38 130.5 11.0 1.7 2 0 0 2 2 2 1 Putative vitamin uptake transporter DUF3630 PF12305.8 CAV20343.1 - 4.5e-38 129.2 2.0 5e-38 129.1 2.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3630) RQC PF09382.10 CAV20344.1 - 2e-37 127.5 0.0 5e-37 126.2 0.0 1.7 1 0 0 1 1 1 1 RQC domain Helicase_C PF00271.31 CAV20344.1 - 4.2e-25 88.2 0.0 6.1e-20 71.6 0.0 2.4 2 0 0 2 2 2 2 Helicase conserved C-terminal domain HRDC PF00570.23 CAV20344.1 - 2e-22 79.0 0.0 4e-22 78.0 0.0 1.6 1 0 0 1 1 1 1 HRDC domain DEAD PF00270.29 CAV20344.1 - 5.6e-20 71.8 0.0 1.4e-19 70.5 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase RecQ_Zn_bind PF16124.5 CAV20344.1 - 1.5e-18 67.2 0.6 4.6e-18 65.7 0.6 1.9 1 0 0 1 1 1 1 RecQ zinc-binding zf-CXXC PF02008.20 CAV20344.1 - 0.0094 15.9 0.9 0.022 14.8 0.9 1.6 1 0 0 1 1 1 1 CXXC zinc finger domain ResIII PF04851.15 CAV20344.1 - 0.035 14.1 0.0 0.19 11.7 0.0 2.1 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit EamA PF00892.20 CAV20345.1 - 1.9e-21 76.7 36.2 9e-16 58.3 11.1 2.1 2 0 0 2 2 2 2 EamA-like transporter family RseC_MucC PF04246.12 CAV20345.1 - 0.4 10.6 11.7 0.24 11.3 0.8 3.1 1 1 0 2 2 2 0 Positive regulator of sigma(E), RseC/MucC AraC_binding PF02311.19 CAV20346.1 - 2.9e-21 75.8 1.1 5.1e-21 75.0 1.1 1.3 1 0 0 1 1 1 1 AraC-like ligand binding domain HTH_18 PF12833.7 CAV20346.1 - 2.3e-19 69.5 0.0 4.5e-19 68.5 0.0 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 CAV20346.1 - 1.9e-16 59.7 0.7 5.7e-07 29.5 0.0 3.2 3 0 0 3 3 3 2 Bacterial regulatory helix-turn-helix proteins, AraC family Cupin_2 PF07883.11 CAV20346.1 - 0.0015 18.2 0.2 0.0024 17.5 0.2 1.3 1 0 0 1 1 1 1 Cupin domain AraC_N PF06719.13 CAV20346.1 - 0.17 11.5 0.0 0.29 10.8 0.0 1.4 1 0 0 1 1 1 0 AraC-type transcriptional regulator N-terminus LysE PF01810.18 CAV20347.1 - 3.2e-37 127.9 6.7 3.7e-37 127.7 6.7 1.0 1 0 0 1 1 1 1 LysE type translocator DUF5012 PF16404.5 CAV20347.1 - 0.075 13.2 0.0 0.11 12.6 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5012) DUF5345 PF17280.2 CAV20347.1 - 0.22 11.5 0.3 0.22 11.5 0.3 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF5345) DUF1430 PF07242.11 CAV20347.1 - 1.4 9.3 6.4 0.23 11.7 1.6 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1430) G_glu_transpept PF01019.21 CAV20348.1 - 1.9e-159 531.7 0.1 2.2e-159 531.5 0.1 1.0 1 0 0 1 1 1 1 Gamma-glutamyltranspeptidase Redoxin PF08534.10 CAV20350.1 - 6.4e-26 90.8 0.0 7.5e-26 90.6 0.0 1.0 1 0 0 1 1 1 1 Redoxin AhpC-TSA PF00578.21 CAV20350.1 - 4.2e-15 55.7 0.0 5.7e-15 55.3 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family UvrD_C PF13361.6 CAV20351.1 - 1.5e-78 264.6 0.1 3.3e-78 263.5 0.1 1.6 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain UvrD-helicase PF00580.21 CAV20351.1 - 1.6e-72 244.7 0.0 4.8e-72 243.1 0.0 1.8 2 0 0 2 2 2 1 UvrD/REP helicase N-terminal domain AAA_19 PF13245.6 CAV20351.1 - 3.3e-33 115.1 0.0 1e-32 113.4 0.0 1.9 2 0 0 2 2 2 1 AAA domain UvrD_C_2 PF13538.6 CAV20351.1 - 1.3e-10 40.9 0.0 3.1e-10 39.7 0.0 1.7 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain AAA_30 PF13604.6 CAV20351.1 - 1.7e-09 37.7 0.0 0.00077 19.2 0.0 2.6 2 0 0 2 2 2 2 AAA domain Exonuc_V_gamma PF04257.14 CAV20351.1 - 4.4e-06 25.2 0.2 1.5e-05 23.4 0.2 1.8 1 1 0 1 1 1 1 Exodeoxyribonuclease V, gamma subunit Viral_helicase1 PF01443.18 CAV20351.1 - 0.00011 22.0 0.0 0.5 10.1 0.0 3.3 3 0 0 3 3 3 1 Viral (Superfamily 1) RNA helicase AAA_12 PF13087.6 CAV20351.1 - 0.0011 18.7 0.0 0.043 13.4 0.0 2.6 2 1 0 2 2 2 1 AAA domain AAA_22 PF13401.6 CAV20351.1 - 0.0023 18.2 0.8 1.2 9.4 0.2 2.9 2 1 0 2 2 2 1 AAA domain AAA_11 PF13086.6 CAV20351.1 - 0.0037 17.1 0.1 0.053 13.3 0.0 2.4 2 0 0 2 2 2 1 AAA domain PhoH PF02562.16 CAV20351.1 - 0.023 14.2 0.0 0.17 11.3 0.0 2.1 2 0 0 2 2 2 0 PhoH-like protein DUF2282 PF10048.9 CAV20352.1 - 2.7e-22 78.5 5.9 3.4e-22 78.2 5.9 1.1 1 0 0 1 1 1 1 Predicted integral membrane protein (DUF2282) DUF692 PF05114.13 CAV20353.1 - 2.7e-103 344.7 0.1 3.1e-103 344.6 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF692) DUF2063 PF09836.9 CAV20354.1 - 7e-23 80.7 0.1 1.2e-22 79.9 0.1 1.4 1 0 0 1 1 1 1 Putative DNA-binding domain DoxX PF07681.12 CAV20355.1 - 6.2e-19 68.4 8.0 6.2e-19 68.4 8.0 1.4 2 0 0 2 2 2 1 DoxX DoxD PF04173.13 CAV20355.1 - 3.5e-05 23.8 5.3 0.00019 21.4 1.2 2.1 1 1 1 2 2 2 2 TQO small subunit DoxD DUF5493 PF17597.2 CAV20355.1 - 0.06 13.6 4.9 1.5 9.1 0.1 2.3 1 1 1 2 2 2 0 Family of unknown function (DUF5493) Cas_Cas4 PF01930.17 CAV20356.1 - 0.033 14.3 0.1 0.038 14.1 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function DUF83 DUF438 PF04282.13 CAV20356.1 - 0.14 12.1 1.4 0.28 11.2 0.5 1.8 1 1 1 2 2 2 0 Family of unknown function (DUF438) MFS_1 PF07690.16 CAV20357.1 - 1.4e-46 159.1 42.9 2.2e-46 158.4 42.9 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily MFS_2 PF13347.6 CAV20357.1 - 4.1e-05 22.3 32.2 0.00033 19.3 17.4 2.7 1 1 1 3 3 3 2 MFS/sugar transport protein MFS_1_like PF12832.7 CAV20357.1 - 0.00018 20.5 21.3 0.015 14.2 15.3 2.3 1 1 1 2 2 2 2 MFS_1 like family LysR_substrate PF03466.20 CAV20358.1 - 8.4e-28 97.2 0.0 1.3e-27 96.6 0.0 1.2 1 0 0 1 1 1 1 LysR substrate binding domain HTH_1 PF00126.27 CAV20358.1 - 4.6e-17 61.7 0.1 7.8e-17 61.0 0.1 1.4 1 0 0 1 1 1 1 Bacterial regulatory helix-turn-helix protein, lysR family HTH_5 PF01022.20 CAV20358.1 - 0.0082 16.0 1.9 0.014 15.2 1.9 1.4 1 0 0 1 1 1 1 Bacterial regulatory protein, arsR family Peptidase_M24 PF00557.24 CAV20359.1 - 4e-42 144.3 0.0 5.6e-42 143.8 0.0 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 Creatinase_N_2 PF16189.5 CAV20359.1 - 9.1e-35 120.1 0.0 2.1e-33 115.7 0.0 2.7 3 0 0 3 3 3 1 Creatinase/Prolidase N-terminal domain Creatinase_N PF01321.18 CAV20359.1 - 1.4e-23 84.0 0.0 1.9e-19 70.6 0.0 2.4 2 0 0 2 2 2 2 Creatinase/Prolidase N-terminal domain Peptidase_M24_C PF16188.5 CAV20359.1 - 6.3e-23 80.6 0.3 2.6e-22 78.6 0.3 2.2 1 0 0 1 1 1 1 C-terminal region of peptidase_M24 DNA_pol3_delt_C PF14840.6 CAV20359.1 - 0.069 13.5 0.0 0.14 12.5 0.0 1.4 1 0 0 1 1 1 0 Processivity clamp loader gamma complex DNA pol III C-term CMV_1a PF12467.8 CAV20359.1 - 0.17 12.2 0.0 0.29 11.5 0.0 1.3 1 0 0 1 1 1 0 Cucumber mosaic virus 1a protein family BATS PF06968.13 CAV20360.1 - 2.3e-27 94.9 0.0 7.4e-27 93.3 0.0 1.9 1 0 0 1 1 1 1 Biotin and Thiamin Synthesis associated domain Radical_SAM PF04055.21 CAV20360.1 - 6.3e-10 39.7 0.0 2.9e-09 37.5 0.0 2.0 2 0 0 2 2 2 1 Radical SAM superfamily ThiG PF05690.14 CAV20361.1 - 1.4e-110 368.5 3.5 1.6e-110 368.3 3.5 1.0 1 0 0 1 1 1 1 Thiazole biosynthesis protein ThiG His_biosynth PF00977.21 CAV20361.1 - 2.2e-05 24.1 0.2 7.8e-05 22.2 0.1 1.8 2 0 0 2 2 2 1 Histidine biosynthesis protein NanE PF04131.14 CAV20361.1 - 0.00017 20.9 0.3 0.00049 19.4 0.2 1.7 1 1 1 2 2 2 1 Putative N-acetylmannosamine-6-phosphate epimerase FMN_dh PF01070.18 CAV20361.1 - 0.0005 19.2 0.8 0.00083 18.5 0.8 1.3 1 0 0 1 1 1 1 FMN-dependent dehydrogenase IMPDH PF00478.25 CAV20361.1 - 0.00086 18.4 1.4 0.0013 17.8 1.4 1.2 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain ThiS PF02597.20 CAV20362.1 - 6.4e-13 49.1 0.0 7.5e-13 48.9 0.0 1.0 1 0 0 1 1 1 1 ThiS family ThiF PF00899.21 CAV20363.1 - 2e-58 197.6 0.2 2.5e-58 197.3 0.2 1.0 1 0 0 1 1 1 1 ThiF family Sacchrp_dh_NADP PF03435.18 CAV20363.1 - 5.8e-05 23.4 0.6 0.00028 21.1 0.6 1.9 1 1 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain NAD_binding_7 PF13241.6 CAV20363.1 - 0.00028 21.3 0.0 0.00049 20.5 0.0 1.3 1 0 0 1 1 1 1 Putative NAD(P)-binding DAO PF01266.24 CAV20363.1 - 0.0041 16.8 0.0 0.0051 16.4 0.0 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase Shikimate_DH PF01488.20 CAV20363.1 - 0.012 15.7 0.0 0.02 14.9 0.0 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Pyr_redox_2 PF07992.14 CAV20363.1 - 0.051 12.8 0.0 0.068 12.4 0.0 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Gp_dh_N PF00044.24 CAV20363.1 - 0.093 13.1 0.0 0.27 11.6 0.0 1.8 2 0 0 2 2 2 0 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain 2-Hacid_dh_C PF02826.19 CAV20363.1 - 0.13 11.7 0.0 0.28 10.5 0.0 1.6 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain TMP-TENI PF02581.17 CAV20364.1 - 2.5e-50 170.3 0.0 3.6e-50 169.8 0.0 1.2 1 0 0 1 1 1 1 Thiamine monophosphate synthase ThiC_Rad_SAM PF01964.18 CAV20365.1 - 4.1e-199 661.6 0.0 4.8e-199 661.4 0.0 1.0 1 0 0 1 1 1 1 Radical SAM ThiC family ThiC-associated PF13667.6 CAV20365.1 - 7.2e-33 112.3 0.1 1.9e-32 110.9 0.1 1.8 1 0 0 1 1 1 1 ThiC-associated domain CRCB PF02537.15 CAV20366.1 - 1.8e-23 82.6 9.9 2.3e-23 82.3 9.9 1.1 1 0 0 1 1 1 1 CrcB-like protein, Camphor Resistance (CrcB) ATP-synt_J PF04911.12 CAV20366.1 - 0.19 11.3 0.0 0.4 10.3 0.0 1.5 1 0 0 1 1 1 0 ATP synthase j chain Cu-oxidase_3 PF07732.15 CAV20367.1 - 3.4e-43 146.4 0.6 3e-38 130.5 0.0 3.0 2 1 0 2 2 2 2 Multicopper oxidase Cu-oxidase_2 PF07731.14 CAV20367.1 - 3.1e-35 120.9 3.5 4.8e-26 91.1 0.4 4.1 3 1 0 3 3 3 3 Multicopper oxidase Cu-oxidase PF00394.22 CAV20367.1 - 1e-21 77.7 0.0 4e-09 36.8 0.0 3.3 3 0 0 3 3 3 3 Multicopper oxidase TAT_signal PF10518.9 CAV20367.1 - 0.0011 18.7 0.0 0.0017 18.1 0.0 1.3 1 0 0 1 1 1 1 TAT (twin-arginine translocation) pathway signal sequence Cupredoxin_1 PF13473.6 CAV20367.1 - 0.012 15.7 0.0 0.31 11.1 0.0 2.7 2 1 0 2 2 2 0 Cupredoxin-like domain DUF2574 PF10836.8 CAV20367.1 - 0.17 11.8 0.0 37 4.3 0.0 3.6 3 1 1 4 4 4 0 Protein of unknown function (DUF2574) Hexapep PF00132.24 CAV20368.1 - 8.8e-19 66.4 10.4 2.8e-07 30.0 0.8 4.3 3 1 1 4 4 4 4 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 CAV20368.1 - 0.00047 19.8 10.6 0.0014 18.3 2.5 4.4 3 2 1 4 4 4 3 Hexapeptide repeat of succinyl-transferase DUF4954 PF16314.5 CAV20368.1 - 0.16 10.1 0.5 0.27 9.3 0.2 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4954) DUF1488 PF07369.11 CAV20369.1 - 2.7e-24 85.0 0.4 3e-24 84.8 0.4 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1488) Shikimate_dh_N PF08501.11 CAV20370.1 - 1.7e-22 79.5 0.0 3e-22 78.7 0.0 1.4 1 0 0 1 1 1 1 Shikimate dehydrogenase substrate binding domain Shikimate_DH PF01488.20 CAV20370.1 - 7.8e-13 48.7 0.0 1.7e-12 47.6 0.0 1.5 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase SDH_C PF18317.1 CAV20370.1 - 2.6e-10 39.9 0.7 4.5e-10 39.1 0.7 1.4 1 0 0 1 1 1 1 Shikimate 5'-dehydrogenase C-terminal domain Sacchrp_dh_NADP PF03435.18 CAV20370.1 - 0.0055 17.0 0.0 0.011 16.0 0.0 1.5 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain Peptidase_S41 PF03572.18 CAV20370.1 - 0.044 13.4 0.7 4.8 6.7 0.0 2.8 2 1 1 3 3 3 0 Peptidase family S41 Coprogen_oxidas PF01218.18 CAV20371.1 - 6.5e-130 432.2 0.0 7.3e-130 432.0 0.0 1.0 1 0 0 1 1 1 1 Coproporphyrinogen III oxidase Sua5_yciO_yrdC PF01300.18 CAV20372.1 - 4.5e-50 169.6 0.0 5e-50 169.5 0.0 1.0 1 0 0 1 1 1 1 Telomere recombination AIRC PF00731.20 CAV20373.1 - 8.8e-64 213.6 4.0 9.9e-64 213.4 4.0 1.0 1 0 0 1 1 1 1 AIR carboxylase ATP-grasp PF02222.22 CAV20374.1 - 1.9e-51 174.0 0.0 3e-51 173.4 0.0 1.2 1 0 0 1 1 1 1 ATP-grasp domain PurK_C PF17769.1 CAV20374.1 - 7.4e-19 67.2 0.1 1.4e-18 66.3 0.1 1.5 1 0 0 1 1 1 1 Phosphoribosylaminoimidazole carboxylase C-terminal domain DUF1471 PF07338.13 CAV20374.1 - 0.027 14.4 0.1 0.4 10.7 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1471) GARS_A PF01071.19 CAV20374.1 - 0.047 13.5 0.0 0.092 12.5 0.0 1.5 2 0 0 2 2 2 0 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain zf-C4_Topoisom PF01396.19 CAV20375.1 - 6.3e-47 157.1 29.6 5.7e-16 58.0 3.2 4.1 4 0 0 4 4 4 3 Topoisomerase DNA binding C4 zinc finger PhnA_Zn_Ribbon PF08274.12 CAV20375.1 - 0.00025 20.9 7.5 0.044 13.7 0.0 4.3 4 1 0 4 4 3 1 PhnA Zinc-Ribbon DUF1272 PF06906.11 CAV20375.1 - 0.0022 18.0 13.2 0.17 12.0 0.1 4.5 4 0 0 4 4 4 1 Protein of unknown function (DUF1272) zinc_ribbon_9 PF14369.6 CAV20375.1 - 0.0035 17.6 10.8 0.22 11.8 0.2 4.2 4 0 0 4 4 3 2 zinc-ribbon PADR1 PF08063.12 CAV20375.1 - 0.018 14.8 0.6 0.018 14.8 0.6 4.6 4 1 0 4 4 4 0 PADR1 (NUC008) domain Zn-ribbon_8 PF09723.10 CAV20375.1 - 0.033 14.3 19.6 0.8 9.9 1.6 4.6 4 0 0 4 4 4 0 Zinc ribbon domain Toprim_C_rpt PF13368.6 CAV20375.1 - 0.12 12.4 0.0 11 6.1 0.0 2.4 2 0 0 2 2 2 0 Topoisomerase C-terminal repeat Auto_anti-p27 PF06677.12 CAV20375.1 - 0.14 12.3 9.4 7.3 6.8 0.2 4.4 4 0 0 4 4 4 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) zinc_ribbon_2 PF13240.6 CAV20375.1 - 0.18 11.5 12.4 10 6.0 0.2 4.4 4 0 0 4 4 4 0 zinc-ribbon domain Zn_Tnp_IS1 PF03811.13 CAV20375.1 - 0.18 11.5 0.0 0.18 11.5 0.0 4.1 4 0 0 4 4 4 0 InsA N-terminal domain DUF3797 PF12677.7 CAV20375.1 - 0.24 11.3 7.7 6.9 6.6 0.3 3.8 3 1 0 3 3 3 0 Domain of unknown function (DUF3797) YacG PF03884.14 CAV20375.1 - 0.27 11.0 9.2 23 4.8 0.2 3.9 3 1 0 3 3 3 0 DNA gyrase inhibitor YacG zf-ribbon_3 PF13248.6 CAV20375.1 - 0.39 10.2 14.2 6 6.4 0.1 4.8 5 0 0 5 5 5 0 zinc-ribbon domain DNA_ligase_ZBD PF03119.16 CAV20375.1 - 0.43 10.6 12.3 20 5.3 0.3 4.3 3 1 0 3 3 3 0 NAD-dependent DNA ligase C4 zinc finger domain Lar_restr_allev PF14354.6 CAV20375.1 - 0.49 10.8 21.6 0.48 10.9 0.7 3.6 2 1 1 3 3 3 0 Restriction alleviation protein Lar Prim_Zn_Ribbon PF08273.12 CAV20375.1 - 0.52 10.6 0.3 0.52 10.6 0.3 3.6 3 0 0 3 3 3 0 Zinc-binding domain of primase-helicase zf-TFIIB PF13453.6 CAV20375.1 - 0.58 9.5 15.4 0.71 9.3 0.1 4.2 4 1 1 5 5 5 0 Transcription factor zinc-finger zinc-ribbons_6 PF07191.12 CAV20375.1 - 1.1 9.3 19.4 3.1 7.8 6.0 3.6 2 1 1 3 3 3 0 zinc-ribbons zf-RING_7 PF02591.15 CAV20375.1 - 2.3 8.5 14.4 1.2 9.4 0.5 4.5 4 0 0 4 4 4 0 C4-type zinc ribbon domain TF_Zn_Ribbon PF08271.12 CAV20375.1 - 2.5 7.7 10.1 5.4 6.6 0.3 3.8 4 0 0 4 4 4 0 TFIIB zinc-binding Terminase_GpA PF05876.12 CAV20375.1 - 4 5.9 6.8 0.35 9.4 1.1 1.8 2 0 0 2 2 2 0 Phage terminase large subunit (GpA) zf-IS66 PF13005.7 CAV20375.1 - 5.4 7.5 13.6 19 5.7 0.7 4.5 4 0 0 4 4 4 0 zinc-finger binding domain of transposase IS66 HNH PF01844.23 CAV20375.1 - 7.2 6.9 13.1 11 6.3 1.4 3.7 3 2 0 3 3 3 0 HNH endonuclease ADK_lid PF05191.14 CAV20375.1 - 7.2 6.7 13.3 61 3.7 0.1 4.0 3 1 0 3 3 3 0 Adenylate kinase, active site lid DUF494 PF04361.13 CAV20376.1 - 1.1e-57 194.2 6.0 1.2e-57 194.0 6.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF494) DNA_processg_A PF02481.15 CAV20377.1 - 5e-78 261.2 0.0 6.5e-78 260.8 0.0 1.1 1 0 0 1 1 1 1 DNA recombination-mediator protein A DprA_WH PF17782.1 CAV20377.1 - 5.8e-11 42.3 0.4 1.2e-10 41.3 0.4 1.6 1 0 0 1 1 1 1 DprA winged helix domain LDcluster4 PF18306.1 CAV20377.1 - 0.037 13.6 0.2 0.27 10.8 0.1 2.1 2 0 0 2 2 2 0 SLOG cluster4 family Varsurf_PPLC PF03490.13 CAV20377.1 - 0.043 13.8 0.0 0.086 12.8 0.0 1.4 1 0 0 1 1 1 0 Variant-surface-glycoprotein phospholipase C LysM PF01476.20 CAV20378.1 - 2.5e-12 46.7 0.0 5.6e-12 45.5 0.0 1.6 1 0 0 1 1 1 1 LysM domain FlgT_C PF16538.5 CAV20378.1 - 0.012 16.1 0.7 11 6.6 0.0 3.1 3 0 0 3 3 3 0 Flagellar assembly protein T, C-terminal domain Pep_deformylase PF01327.21 CAV20379.1 - 1.3e-49 167.8 0.0 1.6e-49 167.6 0.0 1.1 1 0 0 1 1 1 1 Polypeptide deformylase DUF1338 PF07063.13 CAV20379.1 - 0.0092 15.2 0.0 0.016 14.5 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1338) Formyl_trans_N PF00551.19 CAV20380.1 - 1.1e-47 162.1 0.0 2.6e-47 160.9 0.0 1.6 2 0 0 2 2 2 1 Formyl transferase Formyl_trans_C PF02911.18 CAV20380.1 - 1.6e-28 98.9 0.1 2.7e-28 98.2 0.1 1.4 1 0 0 1 1 1 1 Formyl transferase, C-terminal domain Methyltr_RsmB-F PF01189.17 CAV20381.1 - 2.2e-67 226.6 0.0 3.5e-67 226.0 0.0 1.3 1 0 0 1 1 1 1 16S rRNA methyltransferase RsmB/F NusB PF01029.18 CAV20381.1 - 7.5e-26 90.9 0.0 1.7e-25 89.8 0.0 1.6 1 0 0 1 1 1 1 NusB family FtsJ PF01728.19 CAV20381.1 - 7.5e-05 22.9 0.0 0.00019 21.6 0.0 1.7 1 1 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_25 PF13649.6 CAV20381.1 - 0.00012 22.7 0.0 0.00067 20.3 0.0 2.3 2 1 0 2 2 1 1 Methyltransferase domain Methyltransf_5 PF01795.19 CAV20381.1 - 0.00031 20.3 0.0 0.00058 19.5 0.0 1.4 1 0 0 1 1 1 1 MraW methylase family Methyltransf_31 PF13847.6 CAV20381.1 - 0.00035 20.4 0.0 0.00073 19.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltr_RsmF_N PF17125.5 CAV20381.1 - 0.002 18.6 0.0 0.0044 17.5 0.0 1.6 1 0 0 1 1 1 1 N-terminal domain of 16S rRNA methyltransferase RsmF MTS PF05175.14 CAV20381.1 - 0.011 15.3 0.0 0.027 14.0 0.0 1.7 1 1 0 1 1 1 0 Methyltransferase small domain Methyltransf_24 PF13578.6 CAV20381.1 - 0.02 15.9 0.2 1.1 10.3 0.1 3.0 2 1 0 2 2 2 0 Methyltransferase domain Bul1_C PF04426.12 CAV20381.1 - 0.075 12.4 0.1 0.13 11.6 0.1 1.3 1 0 0 1 1 1 0 Bul1 C terminus Methyltransf_15 PF09445.10 CAV20381.1 - 0.086 12.4 0.0 0.29 10.7 0.0 1.8 1 1 1 2 2 2 0 RNA cap guanine-N2 methyltransferase PCMT PF01135.19 CAV20381.1 - 0.12 12.2 0.0 17 5.1 0.0 2.2 2 0 0 2 2 2 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) TrkA_N PF02254.18 CAV20382.1 - 3.3e-54 182.1 3.3 1.2e-27 96.5 0.1 2.8 2 0 0 2 2 2 2 TrkA-N domain TrkA_C PF02080.21 CAV20382.1 - 2.8e-23 81.5 0.4 4.6e-11 42.4 0.0 2.7 2 0 0 2 2 2 2 TrkA-C domain F420_oxidored PF03807.17 CAV20382.1 - 3.2e-13 50.1 4.2 2.2e-06 28.1 0.1 3.8 4 2 0 4 4 2 2 NADP oxidoreductase coenzyme F420-dependent Shikimate_DH PF01488.20 CAV20382.1 - 1.9e-12 47.4 2.3 4.7e-05 23.5 0.0 2.8 3 0 0 3 3 3 2 Shikimate / quinate 5-dehydrogenase NAD_binding_7 PF13241.6 CAV20382.1 - 6.8e-12 45.7 2.0 0.00082 19.8 0.0 3.4 2 1 1 3 3 3 2 Putative NAD(P)-binding Sacchrp_dh_NADP PF03435.18 CAV20382.1 - 6.7e-10 39.3 0.6 0.00013 22.3 0.0 2.5 2 0 0 2 2 2 2 Saccharopine dehydrogenase NADP binding domain ApbA PF02558.16 CAV20382.1 - 7.4e-10 38.7 0.4 0.00046 19.9 0.0 3.1 3 0 0 3 3 3 2 Ketopantoate reductase PanE/ApbA NAD_binding_10 PF13460.6 CAV20382.1 - 1.1e-08 35.1 1.5 0.00025 21.0 0.1 2.5 2 1 0 2 2 2 2 NAD(P)H-binding AlaDh_PNT_C PF01262.21 CAV20382.1 - 1e-06 28.2 3.7 0.00054 19.3 0.1 2.7 2 1 1 3 3 3 2 Alanine dehydrogenase/PNT, C-terminal domain NAD_Gly3P_dh_N PF01210.23 CAV20382.1 - 1.7e-06 28.1 0.1 0.046 13.7 0.0 3.1 3 0 0 3 3 3 2 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus Pyr_redox PF00070.27 CAV20382.1 - 2e-06 28.3 0.1 0.09 13.3 0.1 3.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_2 PF03446.15 CAV20382.1 - 2e-06 28.1 2.7 0.012 15.8 0.0 2.8 3 0 0 3 3 2 2 NAD binding domain of 6-phosphogluconate dehydrogenase 3HCDH_N PF02737.18 CAV20382.1 - 5.7e-06 26.3 2.8 0.0096 15.8 0.1 2.6 3 0 0 3 3 3 2 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 2-Hacid_dh_C PF02826.19 CAV20382.1 - 2.7e-05 23.6 0.5 0.0078 15.6 0.1 2.3 2 0 0 2 2 2 2 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NmrA PF05368.13 CAV20382.1 - 4.3e-05 23.2 1.0 0.0057 16.2 0.1 2.3 2 0 0 2 2 2 1 NmrA-like family Pyr_redox_2 PF07992.14 CAV20382.1 - 6.8e-05 22.2 0.1 0.022 14.0 0.0 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase GFO_IDH_MocA PF01408.22 CAV20382.1 - 0.0001 23.1 0.1 0.044 14.6 0.0 2.6 2 0 0 2 2 2 1 Oxidoreductase family, NAD-binding Rossmann fold UDPG_MGDP_dh_N PF03721.14 CAV20382.1 - 0.00023 20.8 0.0 0.0024 17.5 0.0 2.5 3 0 0 3 3 3 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Epimerase PF01370.21 CAV20382.1 - 0.0006 19.3 0.2 0.16 11.4 0.1 2.4 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family adh_short PF00106.25 CAV20382.1 - 0.0013 18.3 0.8 1.9 7.9 0.0 3.2 3 0 0 3 3 3 2 short chain dehydrogenase DAO PF01266.24 CAV20382.1 - 0.0015 18.2 0.1 0.55 9.8 0.0 2.5 2 0 0 2 2 2 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 CAV20382.1 - 0.0024 18.1 0.2 1.5 9.1 0.0 2.8 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain DUF1188 PF06690.11 CAV20382.1 - 0.01 15.4 0.1 1.3 8.6 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1188) K_oxygenase PF13434.6 CAV20382.1 - 0.021 14.0 0.0 0.92 8.6 0.0 2.2 2 0 0 2 2 2 0 L-lysine 6-monooxygenase (NADPH-requiring) ThiF PF00899.21 CAV20382.1 - 0.034 13.5 0.1 4.3 6.6 0.1 2.6 2 0 0 2 2 2 0 ThiF family FAD_binding_3 PF01494.19 CAV20382.1 - 0.067 12.4 0.4 3.1 6.9 0.1 2.5 2 1 0 2 2 2 0 FAD binding domain TrkH PF02386.16 CAV20383.1 - 8.2e-50 169.7 28.2 8e-49 166.4 28.2 1.9 1 1 0 1 1 1 1 Cation transport protein DUF1077 PF06417.12 CAV20383.1 - 0.0097 15.9 11.0 0.19 11.7 2.4 3.7 2 2 2 4 4 4 2 Protein of unknown function (DUF1077) Form-deh_trans PF09163.11 CAV20383.1 - 0.017 14.8 1.3 0.1 12.4 1.3 2.4 1 0 0 1 1 1 0 Formate dehydrogenase N, transmembrane DUF5423 PF17461.2 CAV20383.1 - 0.27 10.0 2.1 0.27 10.1 0.8 1.6 2 0 0 2 2 2 0 Family of unknown function (DUF5423) DUF3157 PF11355.8 CAV20384.1 - 2.6e-44 151.3 1.9 1.5e-43 148.7 1.9 1.8 1 1 0 1 1 1 1 Protein of unknown function (DUF3157) DUF2393 PF09624.10 CAV20384.1 - 0.031 14.3 0.0 0.06 13.3 0.0 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2393) WSK PF03832.13 CAV20384.1 - 0.11 12.2 0.0 0.2 11.4 0.0 1.4 1 0 0 1 1 1 0 WSK motif HlyIII PF03006.20 CAV20385.1 - 2.1e-37 129.0 19.4 2.5e-37 128.8 19.4 1.0 1 0 0 1 1 1 1 Haemolysin-III related Spo0M PF07070.11 CAV20386.1 - 8.4e-76 254.2 0.0 1.1e-75 253.8 0.0 1.1 1 0 0 1 1 1 1 SpoOM protein DUF1040 PF06288.13 CAV20388.1 - 7e-45 151.3 3.6 7.8e-45 151.2 3.6 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1040) Fer4_18 PF13746.6 CAV20390.1 - 7.6e-42 142.1 5.2 2.2e-41 140.6 5.2 1.9 1 0 0 1 1 1 1 4Fe-4S dicluster domain FixG_C PF11614.8 CAV20390.1 - 2e-29 102.2 0.1 2.8e-29 101.8 0.1 1.2 1 0 0 1 1 1 1 IG-like fold at C-terminal of FixG, putative oxidoreductase Fer4_7 PF12838.7 CAV20390.1 - 2.1e-09 37.8 7.1 5e-05 23.8 1.7 2.9 3 0 0 3 3 3 2 4Fe-4S dicluster domain Fer4_5 PF12801.7 CAV20390.1 - 1.4e-08 34.5 7.1 1.4e-08 34.5 7.1 4.0 6 0 0 6 6 4 1 4Fe-4S binding domain Fer4_9 PF13187.6 CAV20390.1 - 1.5e-08 34.6 7.8 5.9e-05 23.2 0.8 3.0 3 1 0 3 3 3 2 4Fe-4S dicluster domain Fer4_8 PF13183.6 CAV20390.1 - 3e-08 34.0 4.2 0.00023 21.5 0.4 2.5 2 0 0 2 2 2 2 4Fe-4S dicluster domain Fer4_17 PF13534.6 CAV20390.1 - 1.7e-07 31.7 9.3 0.00012 22.6 0.5 2.9 3 0 0 3 3 3 2 4Fe-4S dicluster domain Fer4_21 PF14697.6 CAV20390.1 - 2e-06 27.8 9.7 0.0033 17.5 0.8 3.1 3 0 0 3 3 3 2 4Fe-4S dicluster domain Fer4_10 PF13237.6 CAV20390.1 - 2.5e-06 27.5 19.5 0.00031 20.8 11.7 2.7 2 1 1 3 3 3 2 4Fe-4S dicluster domain Fer4 PF00037.27 CAV20390.1 - 1.8e-05 24.4 22.2 0.00038 20.2 3.7 3.0 3 0 0 3 3 3 2 4Fe-4S binding domain Fer4_16 PF13484.6 CAV20390.1 - 0.00015 22.7 9.5 0.084 13.8 3.3 3.2 2 1 1 3 3 3 3 4Fe-4S double cluster binding domain Fer4_4 PF12800.7 CAV20390.1 - 0.0012 19.2 12.8 0.21 12.2 1.5 2.7 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_2 PF12797.7 CAV20390.1 - 0.0026 17.8 18.5 0.017 15.2 2.1 3.1 3 0 0 3 3 3 2 4Fe-4S binding domain Fer4_3 PF12798.7 CAV20390.1 - 0.007 17.2 4.0 0.007 17.2 4.0 3.6 4 0 0 4 4 3 2 4Fe-4S binding domain Fer4_6 PF12837.7 CAV20390.1 - 0.035 14.2 4.6 0.035 14.2 4.6 2.7 3 0 0 3 3 2 0 4Fe-4S binding domain DUF2207 PF09972.9 CAV20390.1 - 1 8.1 5.8 1.7 7.3 0.1 2.5 3 0 0 3 3 3 0 Predicted membrane protein (DUF2207) Fer4_15 PF13459.6 CAV20390.1 - 1.3 9.8 10.1 7.2 7.4 1.4 2.5 1 1 1 2 2 2 0 4Fe-4S single cluster domain APH PF01636.23 CAV20391.1 - 5.6e-41 141.0 0.5 8.4e-41 140.5 0.5 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family EcKinase PF02958.20 CAV20391.1 - 0.0055 16.0 0.0 0.021 14.1 0.1 1.8 1 1 1 2 2 2 1 Ecdysteroid kinase DSBA PF01323.20 CAV20392.1 - 8.4e-30 104.0 0.5 1.7e-28 99.7 0.5 2.0 1 1 0 1 1 1 1 DSBA-like thioredoxin domain Thioredoxin_4 PF13462.6 CAV20392.1 - 1.9e-13 50.9 0.0 2.5e-13 50.5 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin Thioredoxin PF00085.20 CAV20392.1 - 8.9e-07 28.8 0.1 1.9e-06 27.8 0.1 1.5 1 0 0 1 1 1 1 Thioredoxin Glutaredoxin PF00462.24 CAV20392.1 - 0.073 13.3 0.1 13 6.1 0.0 2.5 2 0 0 2 2 2 0 Glutaredoxin Thioredoxin_8 PF13905.6 CAV20392.1 - 0.11 12.8 0.2 0.24 11.7 0.2 1.9 1 1 0 1 1 1 0 Thioredoxin-like DUF2860 PF11059.8 CAV20393.1 - 2.8e-119 397.8 10.7 3.2e-119 397.6 10.7 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2860) OMP_b-brl_2 PF13568.6 CAV20393.1 - 0.055 13.5 5.9 0.12 12.4 0.8 3.0 2 2 1 3 3 3 0 Outer membrane protein beta-barrel domain Mg_chelatase PF01078.21 CAV20394.1 - 4.5e-91 303.8 0.0 6.1e-89 296.9 0.0 2.2 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI ChlI PF13541.6 CAV20394.1 - 9.4e-46 154.6 0.0 1.6e-45 153.9 0.0 1.4 1 0 0 1 1 1 1 Subunit ChlI of Mg-chelatase Mg_chelatase_C PF13335.6 CAV20394.1 - 1.2e-31 109.1 0.6 2.7e-31 108.1 0.6 1.6 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI C-terminal MCM PF00493.23 CAV20394.1 - 1.5e-10 40.6 0.0 2.3e-07 30.1 0.0 2.3 2 0 0 2 2 2 2 MCM P-loop domain AAA_5 PF07728.14 CAV20394.1 - 2.2e-10 40.6 0.0 7.7e-10 38.9 0.0 1.9 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) Sigma54_activat PF00158.26 CAV20394.1 - 1.3e-07 31.5 0.0 9.1e-07 28.7 0.0 2.1 1 1 0 1 1 1 1 Sigma-54 interaction domain AAA_32 PF13654.6 CAV20394.1 - 4.3e-05 22.5 0.0 0.013 14.3 0.0 2.6 3 0 0 3 3 3 1 AAA domain RuvB_N PF05496.12 CAV20394.1 - 0.00086 19.1 0.0 0.051 13.3 0.0 2.8 3 0 0 3 3 3 1 Holliday junction DNA helicase RuvB P-loop domain AAA PF00004.29 CAV20394.1 - 0.0013 19.2 0.4 0.0064 16.9 0.1 2.4 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 CAV20394.1 - 0.0017 18.6 0.0 0.007 16.6 0.0 2.0 2 0 0 2 2 1 1 AAA domain AAA_16 PF13191.6 CAV20394.1 - 0.0021 18.5 0.0 0.0064 16.9 0.0 1.8 1 0 0 1 1 1 1 AAA ATPase domain IstB_IS21 PF01695.17 CAV20394.1 - 0.005 16.6 0.0 0.067 12.9 0.0 2.6 3 0 0 3 3 3 1 IstB-like ATP binding protein Sigma54_activ_2 PF14532.6 CAV20394.1 - 0.0054 16.9 0.0 0.097 12.8 0.0 2.5 1 1 0 1 1 1 1 Sigma-54 interaction domain AAA_18 PF13238.6 CAV20394.1 - 0.0088 16.6 0.0 0.018 15.5 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_7 PF12775.7 CAV20394.1 - 0.012 15.2 0.0 0.02 14.4 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_30 PF13604.6 CAV20394.1 - 0.026 14.3 0.0 0.055 13.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_19 PF13245.6 CAV20394.1 - 0.038 14.3 0.0 0.17 12.2 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_2 PF07724.14 CAV20394.1 - 0.04 14.0 0.0 0.13 12.4 0.0 1.8 1 1 0 1 1 1 0 AAA domain (Cdc48 subfamily) PG_binding_2 PF08823.11 CAV20394.1 - 0.054 13.8 0.4 1.1 9.6 0.0 2.8 2 1 1 3 3 2 0 Putative peptidoglycan binding domain TniB PF05621.11 CAV20394.1 - 0.061 12.7 0.0 0.12 11.7 0.0 1.4 1 0 0 1 1 1 0 Bacterial TniB protein AAA_11 PF13086.6 CAV20394.1 - 0.078 12.7 0.0 0.15 11.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 CAV20394.1 - 0.094 12.9 0.0 0.24 11.6 0.0 1.7 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 CAV20394.1 - 0.13 12.2 0.0 0.25 11.2 0.0 1.5 1 0 0 1 1 1 0 NACHT domain RNA_helicase PF00910.22 CAV20394.1 - 0.14 12.6 0.0 0.24 11.8 0.0 1.4 1 0 0 1 1 1 0 RNA helicase AAA_28 PF13521.6 CAV20394.1 - 0.14 12.4 0.0 0.29 11.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain TPP_enzyme_N PF02776.18 CAV20395.1 - 2.2e-54 183.6 1.3 4.7e-54 182.6 1.3 1.6 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_C PF02775.21 CAV20395.1 - 9.8e-50 168.3 0.7 1.3e-47 161.4 0.0 3.0 2 1 0 2 2 2 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain TPP_enzyme_M PF00205.22 CAV20395.1 - 7.9e-42 142.3 0.1 1.6e-41 141.3 0.1 1.5 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, central domain POR_N PF01855.19 CAV20395.1 - 0.012 15.4 2.3 0.019 14.7 2.3 1.3 1 0 0 1 1 1 0 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg ACT_5 PF13710.6 CAV20396.1 - 8.3e-21 73.6 0.7 1.2e-20 73.1 0.7 1.2 1 0 0 1 1 1 1 ACT domain ACT_4 PF13291.6 CAV20396.1 - 0.0012 19.4 0.2 0.0017 18.9 0.2 1.2 1 0 0 1 1 1 1 ACT domain SbcD_C PF12320.8 CAV20396.1 - 0.029 14.7 0.2 0.052 13.8 0.2 1.5 1 1 0 1 1 1 0 Type 5 capsule protein repressor C-terminal domain Aminotran_4 PF01063.19 CAV20397.1 - 1.1e-46 159.5 0.0 1.3e-46 159.3 0.0 1.1 1 0 0 1 1 1 1 Amino-transferase class IV ILVD_EDD PF00920.21 CAV20398.1 - 4.8e-216 718.4 4.9 5.4e-216 718.2 4.9 1.0 1 0 0 1 1 1 1 Dehydratase family PALP PF00291.25 CAV20399.1 - 1.1e-82 277.8 1.2 1.4e-82 277.5 1.2 1.1 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Thr_dehydrat_C PF00585.18 CAV20399.1 - 3.2e-54 180.7 0.0 4.8e-26 90.4 0.0 2.4 2 0 0 2 2 2 2 C-terminal regulatory domain of Threonine dehydratase DUF3970 PF13113.6 CAV20399.1 - 0.0098 16.1 0.1 0.079 13.2 0.0 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF3970) LysR_substrate PF03466.20 CAV20400.1 - 5.5e-22 78.2 0.0 9.4e-22 77.4 0.0 1.3 1 0 0 1 1 1 1 LysR substrate binding domain HTH_1 PF00126.27 CAV20400.1 - 7.7e-17 61.0 0.1 1.7e-16 59.9 0.1 1.6 1 0 0 1 1 1 1 Bacterial regulatory helix-turn-helix protein, lysR family MFS_1 PF07690.16 CAV20401.1 - 4.6e-35 121.2 31.4 4.6e-35 121.2 31.4 1.6 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CAV20401.1 - 1.6e-07 30.6 5.5 1.6e-07 30.6 5.5 2.5 1 1 1 2 2 2 1 Sugar (and other) transporter MFS_3 PF05977.13 CAV20401.1 - 0.0067 14.9 1.1 0.0067 14.9 1.1 3.3 2 2 1 3 3 3 2 Transmembrane secretion effector MFS_1_like PF12832.7 CAV20401.1 - 0.033 13.1 18.7 0.26 10.1 5.6 2.2 1 1 1 2 2 2 0 MFS_1 like family Hexapep PF00132.24 CAV20402.1 - 2.9e-26 90.2 20.8 1.1e-08 34.4 0.7 5.3 2 1 5 7 7 7 6 Bacterial transferase hexapeptide (six repeats) NTP_transf_3 PF12804.7 CAV20402.1 - 5.2e-23 82.2 0.1 1.2e-22 81.0 0.1 1.7 1 1 0 1 1 1 1 MobA-like NTP transferase domain Hexapep_2 PF14602.6 CAV20402.1 - 6.2e-13 48.3 25.5 3.2e-08 33.2 0.6 5.0 3 1 1 5 5 5 4 Hexapeptide repeat of succinyl-transferase NTP_transferase PF00483.23 CAV20402.1 - 1.3e-11 44.6 0.0 1.9e-11 44.1 0.0 1.2 1 0 0 1 1 1 1 Nucleotidyl transferase IspD PF01128.19 CAV20402.1 - 9.7e-08 32.0 0.3 4.3e-07 29.9 0.1 2.1 2 0 0 2 2 2 1 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase CofC PF01983.16 CAV20402.1 - 0.0014 17.9 0.0 0.0024 17.1 0.0 1.3 1 0 0 1 1 1 1 Guanylyl transferase CofC like CTP_transf_3 PF02348.19 CAV20402.1 - 0.0021 18.0 0.0 0.025 14.5 0.0 2.4 1 1 0 1 1 1 1 Cytidylyltransferase Fucokinase PF07959.12 CAV20402.1 - 0.0075 15.3 0.2 0.24 10.3 0.3 2.5 1 1 2 3 3 3 1 L-fucokinase DUF4954 PF16314.5 CAV20402.1 - 0.09 10.9 2.4 0.086 11.0 1.3 1.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4954) ATP-synt_DE_N PF02823.16 CAV20403.1 - 7.7e-29 99.4 0.7 1.1e-28 98.9 0.7 1.3 1 0 0 1 1 1 1 ATP synthase, Delta/Epsilon chain, beta-sandwich domain ATP-synt_DE PF00401.20 CAV20403.1 - 2e-09 37.6 8.9 2.9e-09 37.0 8.9 1.3 1 0 0 1 1 1 1 ATP synthase, Delta/Epsilon chain, long alpha-helix domain ATP-synt_ab PF00006.25 CAV20404.1 - 1.5e-59 201.3 0.0 2.3e-59 200.6 0.0 1.3 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_N PF02874.23 CAV20404.1 - 1.2e-20 73.7 5.1 3.5e-20 72.3 5.1 1.8 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain T3SS_ATPase_C PF18269.1 CAV20404.1 - 0.02 14.8 0.2 0.18 11.7 0.2 2.4 1 1 0 1 1 1 0 T3SS EscN ATPase C-terminal domain ATP-synt PF00231.19 CAV20405.1 - 1.8e-98 329.7 0.1 2e-98 329.5 0.1 1.0 1 0 0 1 1 1 1 ATP synthase Flu_M1_C PF08289.11 CAV20405.1 - 0.54 10.5 4.3 14 6.0 0.1 2.8 3 0 0 3 3 3 0 Influenza Matrix protein (M1) C-terminal domain ATP-synt_ab PF00006.25 CAV20406.1 - 6.3e-71 238.4 0.1 9.6e-71 237.8 0.1 1.3 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_C PF00306.27 CAV20406.1 - 1.3e-44 151.6 3.7 2e-44 150.9 3.7 1.3 1 0 0 1 1 1 1 ATP synthase alpha/beta chain, C terminal domain ATP-synt_ab_N PF02874.23 CAV20406.1 - 1.6e-13 50.9 0.4 3.6e-13 49.8 0.4 1.6 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain ATPase PF06745.13 CAV20406.1 - 0.002 17.5 0.1 0.004 16.5 0.1 1.5 1 0 0 1 1 1 1 KaiC HAS-barrel PF09378.10 CAV20406.1 - 0.0048 17.0 0.4 0.012 15.7 0.1 1.9 2 0 0 2 2 2 1 HAS barrel domain Viral_cys_rich PF08008.12 CAV20406.1 - 0.089 12.8 0.0 2.8 8.1 0.0 2.5 2 0 0 2 2 2 0 Viral cysteine rich OSCP PF00213.18 CAV20407.1 - 1.9e-50 171.3 0.3 2.2e-50 171.2 0.3 1.0 1 0 0 1 1 1 1 ATP synthase delta (OSCP) subunit DUF496 PF04363.12 CAV20407.1 - 0.098 12.7 0.2 0.2 11.7 0.2 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF496) ATP-synt_B PF00430.18 CAV20408.1 - 4.6e-35 120.6 19.1 5.3e-35 120.4 19.1 1.0 1 0 0 1 1 1 1 ATP synthase B/B' CF(0) ESM4 PF15952.5 CAV20408.1 - 0.0036 17.8 1.8 0.0056 17.1 1.8 1.3 1 0 0 1 1 1 1 Enhancer of split M4 family Mt_ATP-synt_B PF05405.14 CAV20408.1 - 0.023 14.3 5.2 0.039 13.6 5.1 1.5 1 1 0 1 1 1 0 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) CRISPR_Cse1 PF09481.10 CAV20408.1 - 0.044 12.9 7.1 0.054 12.6 7.1 1.0 1 0 0 1 1 1 0 CRISPR-associated protein Cse1 (CRISPR_cse1) V-ATPase_G PF03179.15 CAV20408.1 - 0.079 13.5 25.1 0.054 14.0 17.1 2.4 1 1 1 2 2 2 0 Vacuolar (H+)-ATPase G subunit HrpE PF06188.12 CAV20408.1 - 0.19 11.6 14.4 0.22 11.4 14.4 1.2 1 0 0 1 1 1 0 HrpE/YscL/FliH and V-type ATPase subunit E DivIVA PF05103.13 CAV20408.1 - 0.99 9.5 23.6 0.36 10.9 13.0 2.2 1 1 1 2 2 2 0 DivIVA protein ATP-synt_C PF00137.21 CAV20409.1 - 3.2e-10 40.2 12.4 4.1e-10 39.8 12.4 1.1 1 0 0 1 1 1 1 ATP synthase subunit C ATP-synt_A PF00119.20 CAV20410.1 - 2.2e-58 197.7 22.2 2.6e-58 197.5 22.2 1.0 1 0 0 1 1 1 1 ATP synthase A chain ATP-synt_I PF03899.15 CAV20411.1 - 3.4e-17 62.6 13.1 4.4e-17 62.3 13.1 1.1 1 0 0 1 1 1 1 ATP synthase I chain ParBc PF02195.18 CAV20412.1 - 2.9e-27 94.8 0.3 1.2e-26 92.8 0.3 2.1 1 0 0 1 1 1 1 ParB-like nuclease domain HTH_ParB PF17762.1 CAV20412.1 - 3.7e-16 58.7 1.4 3.7e-16 58.7 1.4 3.4 3 0 0 3 3 3 1 HTH domain found in ParB protein Sigma70_r4 PF04545.16 CAV20412.1 - 0.0001 21.7 0.8 0.031 13.8 0.2 2.7 2 1 0 2 2 2 2 Sigma-70, region 4 HTH_23 PF13384.6 CAV20412.1 - 0.00043 20.0 1.9 0.0056 16.5 0.0 3.0 3 0 0 3 3 3 1 Homeodomain-like domain HTH_Crp_2 PF13545.6 CAV20412.1 - 0.0009 19.2 0.4 0.0029 17.5 0.1 2.1 2 0 0 2 2 2 1 Crp-like helix-turn-helix domain HTH_37 PF13744.6 CAV20412.1 - 0.0062 16.5 3.0 0.057 13.4 0.3 2.7 1 1 1 2 2 2 1 Helix-turn-helix domain HTH_3 PF01381.22 CAV20412.1 - 0.012 15.7 0.1 0.04 14.0 0.1 2.0 1 0 0 1 1 1 0 Helix-turn-helix Sigma70_r4_2 PF08281.12 CAV20412.1 - 0.018 14.7 0.0 0.051 13.3 0.0 1.8 1 0 0 1 1 1 0 Sigma-70, region 4 HTH_38 PF13936.6 CAV20412.1 - 0.033 13.9 0.1 0.077 12.8 0.1 1.7 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_29 PF13551.6 CAV20412.1 - 0.071 13.2 0.2 0.39 10.8 0.0 2.2 2 0 0 2 2 2 0 Winged helix-turn helix HTH_31 PF13560.6 CAV20412.1 - 0.44 10.9 4.3 0.44 10.9 1.4 2.6 2 1 0 2 2 2 0 Helix-turn-helix domain AAA_31 PF13614.6 CAV20413.1 - 4.6e-63 212.3 0.7 7.2e-63 211.7 0.7 1.3 1 0 0 1 1 1 1 AAA domain CbiA PF01656.23 CAV20413.1 - 1.4e-27 96.3 0.1 2e-27 95.8 0.1 1.2 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain CBP_BcsQ PF06564.12 CAV20413.1 - 2.3e-13 50.2 0.0 8.1e-13 48.4 0.0 1.7 1 1 0 1 1 1 1 Cellulose biosynthesis protein BcsQ MipZ PF09140.11 CAV20413.1 - 6.3e-13 48.6 0.9 1.9e-11 43.7 0.9 2.3 1 1 0 1 1 1 1 ATPase MipZ Fer4_NifH PF00142.18 CAV20413.1 - 1e-10 41.5 0.2 3.4e-10 39.8 0.2 1.8 1 1 0 1 1 1 1 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family ParA PF10609.9 CAV20413.1 - 1.3e-09 37.9 0.4 1.2e-08 34.7 0.4 2.2 1 1 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase ArsA_ATPase PF02374.15 CAV20413.1 - 3.4e-07 29.7 1.2 1.6e-05 24.3 0.4 2.3 1 1 0 2 2 2 1 Anion-transporting ATPase ATP_bind_1 PF03029.17 CAV20413.1 - 0.00024 21.0 0.2 0.00075 19.3 0.1 1.9 1 1 0 1 1 1 1 Conserved hypothetical ATP binding protein CLP1_P PF16575.5 CAV20413.1 - 0.00076 19.3 0.0 0.0019 18.1 0.0 1.6 1 0 0 1 1 1 1 mRNA cleavage and polyadenylation factor CLP1 P-loop VirC1 PF07015.11 CAV20413.1 - 0.0011 18.3 0.5 0.0056 16.0 0.1 1.9 2 0 0 2 2 2 1 VirC1 protein SRP54 PF00448.22 CAV20413.1 - 0.0026 17.4 0.5 0.017 14.7 0.2 2.2 2 1 0 2 2 2 1 SRP54-type protein, GTPase domain AAA_25 PF13481.6 CAV20413.1 - 0.024 14.2 0.0 0.035 13.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain GidB PF02527.15 CAV20414.1 - 7e-63 211.3 0.0 8.4e-63 211.0 0.0 1.0 1 0 0 1 1 1 1 rRNA small subunit methyltransferase G Methyltransf_31 PF13847.6 CAV20414.1 - 3e-07 30.4 0.0 4.1e-07 29.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CAV20414.1 - 0.00053 20.6 0.0 0.001 19.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 CAV20414.1 - 0.0024 17.4 0.0 0.0037 16.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain Ad_Cy_reg PF16701.5 CAV20414.1 - 0.037 13.8 0.0 0.066 12.9 0.0 1.3 1 0 0 1 1 1 0 Adenylate cyclase regulatory domain Methyltransf_16 PF10294.9 CAV20414.1 - 0.04 13.7 0.0 0.077 12.7 0.0 1.6 1 1 0 1 1 1 0 Lysine methyltransferase Methyltransf_12 PF08242.12 CAV20414.1 - 0.074 13.8 0.0 0.15 12.8 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_11 PF08241.12 CAV20414.1 - 0.079 13.6 0.0 0.13 12.9 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain GIDA PF01134.22 CAV20415.1 - 2.2e-168 560.4 0.0 6.4e-168 558.9 0.0 1.6 2 0 0 2 2 2 1 Glucose inhibited division protein A GIDA_assoc PF13932.6 CAV20415.1 - 5.1e-76 255.5 2.0 7.1e-76 255.0 2.0 1.2 1 0 0 1 1 1 1 GidA associated domain FAD_binding_2 PF00890.24 CAV20415.1 - 3.9e-08 32.8 3.8 0.0004 19.6 0.7 2.3 2 0 0 2 2 2 2 FAD binding domain FAD_oxidored PF12831.7 CAV20415.1 - 4.1e-08 33.0 3.7 8.2e-08 32.0 3.7 1.5 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 CAV20415.1 - 0.00016 21.0 1.3 0.00045 19.5 1.3 1.7 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 CAV20415.1 - 0.0013 17.6 1.6 0.023 13.4 0.1 2.9 3 0 0 3 3 3 1 HI0933-like protein Thi4 PF01946.17 CAV20415.1 - 0.006 15.9 1.3 0.032 13.5 1.3 2.0 1 1 0 1 1 1 1 Thi4 family Pyr_redox_3 PF13738.6 CAV20415.1 - 0.025 13.9 0.1 0.66 9.2 0.0 2.2 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase AlaDh_PNT_C PF01262.21 CAV20415.1 - 0.026 13.8 0.3 0.048 12.9 0.3 1.5 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain NAD_binding_9 PF13454.6 CAV20415.1 - 0.042 13.8 0.2 0.042 13.8 0.2 1.9 2 0 0 2 2 2 0 FAD-NAD(P)-binding FAD_binding_3 PF01494.19 CAV20415.1 - 0.1 11.8 1.2 2.5 7.3 0.1 2.2 2 0 0 2 2 2 0 FAD binding domain Pyr_redox PF00070.27 CAV20415.1 - 0.11 13.0 0.2 0.46 11.1 0.2 2.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase SnoaL PF07366.12 CAV20415.1 - 0.12 12.1 0.0 0.27 11.0 0.0 1.5 1 0 0 1 1 1 0 SnoaL-like polyketide cyclase DAO PF01266.24 CAV20415.1 - 0.17 11.4 5.4 6 6.3 0.1 2.4 1 1 0 2 2 2 0 FAD dependent oxidoreductase HTH_54 PF18607.1 CAV25166.1 - 1.5e-24 85.8 0.7 2.7e-24 85.0 0.7 1.4 1 0 0 1 1 1 1 ParA helix turn helix domain AAA_31 PF13614.6 CAV25166.1 - 2.5e-22 79.7 0.0 8.5e-22 77.9 0.0 1.8 2 0 0 2 2 2 1 AAA domain CbiA PF01656.23 CAV25166.1 - 2.8e-13 50.1 0.0 6.8e-13 48.8 0.0 1.7 2 0 0 2 2 2 1 CobQ/CobB/MinD/ParA nucleotide binding domain MipZ PF09140.11 CAV25166.1 - 1.9e-08 33.9 0.1 1e-05 24.9 0.0 2.6 3 0 0 3 3 3 2 ATPase MipZ ParA PF10609.9 CAV25166.1 - 5.3e-05 22.8 0.0 0.00016 21.2 0.0 1.9 1 1 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase VirC1 PF07015.11 CAV25166.1 - 0.013 14.8 0.0 2 7.7 0.0 2.4 2 0 0 2 2 2 0 VirC1 protein ArsA_ATPase PF02374.15 CAV25166.1 - 0.05 12.8 0.3 0.21 10.7 0.0 2.1 2 1 0 2 2 2 0 Anion-transporting ATPase DUF2280 PF10045.9 CAV25166.1 - 0.05 13.9 0.0 0.13 12.5 0.0 1.6 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2280) ParBc PF02195.18 CAV25168.1 - 4.8e-08 33.2 0.0 1e-07 32.2 0.0 1.6 1 0 0 1 1 1 1 ParB-like nuclease domain Helicase_RecD PF05127.14 CAV25170.1 - 1.9e-56 190.7 0.0 3.4e-56 189.9 0.0 1.4 1 0 0 1 1 1 1 Helicase GNAT_acetyltr_2 PF13718.6 CAV25170.1 - 5.9e-30 104.3 0.0 4e-16 59.1 0.0 2.3 1 1 1 2 2 2 2 GNAT acetyltransferase 2 DUF1726 PF08351.11 CAV25170.1 - 3.7e-06 26.8 0.0 1.4e-05 24.9 0.0 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF1726) AAA_30 PF13604.6 CAV25170.1 - 0.00013 21.7 0.0 0.00025 20.8 0.0 1.4 1 0 0 1 1 1 1 AAA domain Acetyltransf_10 PF13673.7 CAV25170.1 - 0.00016 21.6 0.0 0.0011 18.9 0.0 2.3 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain tRNA_bind_3 PF17176.4 CAV25170.1 - 0.00024 21.4 0.0 0.0029 17.9 0.0 2.8 2 1 0 2 2 2 1 tRNA-binding domain Acetyltransf_7 PF13508.7 CAV25170.1 - 0.002 18.5 0.0 0.0071 16.8 0.0 2.0 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 CAV25170.1 - 0.019 15.2 0.0 0.099 12.9 0.0 2.2 2 0 0 2 2 2 0 Acetyltransferase (GNAT) family AAA_19 PF13245.6 CAV25170.1 - 0.034 14.5 0.0 0.1 12.9 0.0 2.0 1 1 0 1 1 1 0 AAA domain Cro PF09048.10 CAV25170.1 - 0.11 12.5 0.0 0.23 11.5 0.0 1.4 1 0 0 1 1 1 0 Cro FapA PF03961.13 CAV25172.1 - 6.7e-121 404.0 10.1 1.7e-120 402.7 9.4 1.7 2 0 0 2 2 2 1 Flagellar Assembly Protein A MinC_C PF03775.16 CAV25172.1 - 0.083 12.9 0.3 0.083 12.9 0.3 3.0 3 1 1 4 4 4 0 Septum formation inhibitor MinC, C-terminal domain DUF4407 PF14362.6 CAV25172.1 - 1.6 8.0 4.8 2.6 7.3 4.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) CENP-H PF05837.12 CAV25172.1 - 4.3 7.8 9.0 8.5 6.8 9.0 1.4 1 0 0 1 1 1 0 Centromere protein H (CENP-H) ABC_tran PF00005.27 CAV25174.1 - 2e-34 119.0 0.0 5.6e-34 117.6 0.0 1.8 1 0 0 1 1 1 1 ABC transporter ABC_membrane PF00664.23 CAV25174.1 - 1.7e-18 67.2 14.1 2.4e-18 66.8 14.1 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region SMC_N PF02463.19 CAV25174.1 - 3.4e-05 23.4 0.0 0.0012 18.4 0.0 2.0 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 CAV25174.1 - 0.0063 16.2 0.1 0.017 14.8 0.1 1.7 1 0 0 1 1 1 1 P-loop containing region of AAA domain Peptidase_C39 PF03412.15 CAV25174.1 - 0.0092 15.8 0.0 0.021 14.7 0.0 1.6 1 0 0 1 1 1 1 Peptidase C39 family SLATT_1 PF18181.1 CAV25174.1 - 0.1 12.5 1.3 0.27 11.2 0.1 2.2 2 0 0 2 2 2 0 SMODS and SLOG-associating 2TM effector domain 1 Zeta_toxin PF06414.12 CAV25174.1 - 0.11 11.8 0.0 0.21 10.8 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin AAA_21 PF13304.6 CAV25174.1 - 0.13 12.1 0.0 3.9 7.2 0.0 2.7 3 0 0 3 3 3 0 AAA domain, putative AbiEii toxin, Type IV TA system LapD_MoxY_N PF16448.5 CAV25176.1 - 8.2e-39 132.3 0.0 1.6e-38 131.4 0.0 1.5 1 0 0 1 1 1 1 LapD/MoxY periplasmic domain EAL PF00563.20 CAV25176.1 - 1.7e-33 116.2 0.1 3.2e-33 115.2 0.1 1.5 1 0 0 1 1 1 1 EAL domain GGDEF PF00990.21 CAV25176.1 - 3.6e-16 59.3 0.0 1.2e-15 57.6 0.0 1.9 2 0 0 2 2 2 1 Diguanylate cyclase, GGDEF domain Peptidase_C93 PF06035.11 CAV25179.1 - 9e-14 51.6 0.0 1.3e-13 51.1 0.0 1.2 1 0 0 1 1 1 1 Bacterial transglutaminase-like cysteine proteinase BTLCP DUF553 PF04473.12 CAV25179.1 - 0.096 12.2 0.0 0.14 11.7 0.0 1.3 1 0 0 1 1 1 0 Transglutaminase-like domain HlyD_3 PF13437.6 CAV25182.1 - 2.1e-19 70.2 5.0 2.6e-16 60.2 0.2 3.2 3 0 0 3 3 3 2 HlyD family secretion protein HlyD_D23 PF16576.5 CAV25182.1 - 4.1e-08 32.7 4.4 4.9e-05 22.6 1.0 2.6 2 1 0 2 2 2 2 Barrel-sandwich domain of CusB or HlyD membrane-fusion Biotin_lipoyl_2 PF13533.6 CAV25182.1 - 3.4e-07 30.0 0.7 3.4e-07 30.0 0.7 2.3 2 0 0 2 2 2 1 Biotin-lipoyl like HlyD PF00529.20 CAV25182.1 - 3.1e-05 23.8 0.0 5.6e-05 23.0 0.0 1.6 1 1 0 1 1 1 1 HlyD membrane-fusion protein of T1SS OEP PF02321.18 CAV25182.1 - 0.00011 22.1 6.3 0.00011 22.1 6.3 2.2 2 1 1 3 3 3 1 Outer membrane efflux protein MPS2 PF17060.5 CAV25182.1 - 0.021 14.1 2.4 0.031 13.6 2.4 1.3 1 0 0 1 1 1 0 Monopolar spindle protein 2 Biotin_lipoyl PF00364.22 CAV25182.1 - 0.023 14.5 5.2 0.042 13.7 0.5 2.6 2 0 0 2 2 2 0 Biotin-requiring enzyme PTS_EIIA_1 PF00358.20 CAV25182.1 - 0.023 14.4 0.7 1.3 8.8 0.1 2.8 3 0 0 3 3 3 0 phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1 FtsH_ext PF06480.15 CAV25182.1 - 0.11 12.9 0.4 0.23 11.8 0.4 1.6 1 0 0 1 1 1 0 FtsH Extracellular RnfC_N PF13375.6 CAV25182.1 - 0.25 11.3 3.5 3.8 7.5 0.2 3.0 3 0 0 3 3 3 0 RnfC Barrel sandwich hybrid domain DUF745 PF05335.13 CAV25182.1 - 0.48 10.1 6.3 0.083 12.6 0.7 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF745) FliJ PF02050.16 CAV25182.1 - 0.62 10.3 13.7 0.043 14.0 2.1 3.0 3 1 1 4 4 4 0 Flagellar FliJ protein BST2 PF16716.5 CAV25182.1 - 3.2 8.4 10.5 29 5.3 2.2 3.5 3 0 0 3 3 3 0 Bone marrow stromal antigen 2 Exonuc_VII_L PF02601.15 CAV25182.1 - 7.5 6.0 14.7 16 4.9 14.7 1.7 1 1 0 1 1 1 0 Exonuclease VII, large subunit Fez1 PF06818.15 CAV25182.1 - 7.8 6.9 14.5 4.2 7.8 2.0 2.6 1 1 0 2 2 2 0 Fez1 Response_reg PF00072.24 CAV25185.1 - 1.6e-26 92.7 0.4 3.1e-26 91.7 0.4 1.5 1 0 0 1 1 1 1 Response regulator receiver domain HTH_8 PF02954.19 CAV25185.1 - 5.6e-08 32.5 0.1 1.7e-07 30.9 0.1 1.9 1 0 0 1 1 1 1 Bacterial regulatory protein, Fis family Sigma54_activ_2 PF14532.6 CAV25185.1 - 1.5e-06 28.3 0.0 3.6e-06 27.2 0.0 1.6 1 0 0 1 1 1 1 Sigma-54 interaction domain Sigma54_activat PF00158.26 CAV25185.1 - 0.00011 21.9 0.0 0.00086 19.0 0.0 2.2 1 1 0 1 1 1 1 Sigma-54 interaction domain DUF2089 PF09862.9 CAV25185.1 - 0.0042 17.1 0.0 0.011 15.7 0.0 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF2089) TadZ_N PF16968.5 CAV25185.1 - 0.0054 16.4 0.1 0.011 15.4 0.1 1.5 1 0 0 1 1 1 1 Pilus assembly protein TadZ N-terminal HTH_17 PF12728.7 CAV25185.1 - 0.0067 16.6 0.0 0.019 15.2 0.0 1.9 1 0 0 1 1 1 1 Helix-turn-helix domain HATPase_c PF02518.26 CAV25188.1 - 2.3e-16 60.3 0.0 5e-16 59.2 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase dCache_1 PF02743.18 CAV25188.1 - 3.6e-14 53.2 4.8 3.6e-14 53.2 4.8 2.6 3 0 0 3 3 3 1 Cache domain dCache_3 PF14827.6 CAV25188.1 - 4.4e-08 33.1 0.6 4.4e-08 33.1 0.6 2.0 2 0 0 2 2 2 1 Double sensory domain of two-component sensor kinase sCache_3_2 PF17203.4 CAV25188.1 - 1e-05 25.7 0.0 3.4e-05 24.0 0.0 1.9 1 0 0 1 1 1 1 Single cache domain 3 HisKA PF00512.25 CAV25188.1 - 1.3e-05 25.1 0.5 1.3e-05 25.1 0.5 2.5 2 1 1 3 3 3 1 His Kinase A (phospho-acceptor) domain HATPase_c_3 PF13589.6 CAV25188.1 - 2.6e-05 24.1 0.0 0.00037 20.3 0.0 2.5 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_5 PF14501.6 CAV25188.1 - 0.00016 21.5 0.0 0.00069 19.5 0.0 2.1 1 1 0 1 1 1 1 GHKL domain DUF2130 PF09903.9 CAV25188.1 - 0.0025 17.2 4.2 0.0025 17.2 4.2 1.8 1 1 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2130) DUF4381 PF14316.6 CAV25188.1 - 0.042 14.1 0.9 0.15 12.3 0.9 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) Putative_PNPOx PF01243.20 CAV25190.1 - 5.5e-25 87.4 0.0 1e-24 86.5 0.0 1.4 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase PNP_phzG_C PF10590.9 CAV25190.1 - 8.2e-18 64.2 3.2 1.5e-17 63.4 3.2 1.4 1 0 0 1 1 1 1 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region Pyrid_ox_like PF16242.5 CAV25190.1 - 0.029 13.9 0.0 0.046 13.3 0.0 1.5 1 0 0 1 1 1 0 Pyridoxamine 5'-phosphate oxidase like PAS_4 PF08448.10 CAV25193.1 - 4.1e-22 78.5 0.0 6.6e-22 77.8 0.0 1.2 1 0 0 1 1 1 1 PAS fold GerE PF00196.19 CAV25193.1 - 3e-15 55.5 0.0 4.9e-15 54.8 0.0 1.3 1 0 0 1 1 1 1 Bacterial regulatory proteins, luxR family Sigma70_r4_2 PF08281.12 CAV25193.1 - 2.5e-05 23.9 0.0 4.3e-05 23.1 0.0 1.3 1 0 0 1 1 1 1 Sigma-70, region 4 HTH_40 PF14493.6 CAV25193.1 - 0.014 15.8 0.0 0.027 14.9 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_11 PF08279.12 CAV25193.1 - 0.13 12.2 0.0 0.25 11.3 0.0 1.5 1 0 0 1 1 1 0 HTH domain FGE-sulfatase PF03781.16 CAV25195.1 - 4.4e-49 167.4 7.1 2.4e-48 165.0 7.1 2.0 1 1 0 1 1 1 1 Sulfatase-modifying factor enzyme 1 PEGA PF08308.11 CAV25195.1 - 6.9e-20 70.7 0.1 1.9e-19 69.3 0.1 1.8 1 0 0 1 1 1 1 PEGA domain RMI1_N PF08585.12 CAV25195.1 - 0.0042 16.9 2.8 0.011 15.5 2.8 1.6 1 0 0 1 1 1 1 RecQ mediated genome instability protein Spc7 PF08317.11 CAV25195.1 - 0.01 14.8 20.3 0.014 14.3 19.3 1.7 1 1 0 1 1 1 0 Spc7 kinetochore protein DUF4724 PF15852.5 CAV25195.1 - 0.072 13.6 0.7 0.32 11.5 0.2 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4724) ATG101 PF07855.12 CAV25195.1 - 0.23 11.4 4.9 1 9.3 4.8 2.1 1 1 0 1 1 1 0 Autophagy-related protein 101 Exonuc_VII_L PF02601.15 CAV25195.1 - 0.59 9.7 19.4 3.7 7.0 19.4 2.1 1 1 0 1 1 1 0 Exonuclease VII, large subunit DUF883 PF05957.13 CAV25195.1 - 2.8 8.6 9.0 7.9 7.2 2.4 2.8 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF883) Jnk-SapK_ap_N PF09744.9 CAV25195.1 - 3.7 7.8 19.7 7.6 6.7 2.9 2.4 2 0 0 2 2 2 0 JNK_SAPK-associated protein-1 DUF4407 PF14362.6 CAV25195.1 - 4.8 6.5 11.1 7.7 5.8 11.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) PEGA PF08308.11 CAV25198.1 - 1.5e-22 79.3 0.3 3.2e-22 78.2 0.3 1.5 1 0 0 1 1 1 1 PEGA domain CarboxypepD_reg PF13620.6 CAV25198.1 - 0.0019 18.4 0.1 0.0083 16.4 0.1 2.2 1 1 0 1 1 1 1 Carboxypeptidase regulatory-like domain CarbopepD_reg_2 PF13715.6 CAV25198.1 - 0.0036 17.3 0.2 0.034 14.2 0.0 2.6 2 0 0 2 2 2 1 CarboxypepD_reg-like domain B12D PF06522.11 CAV25198.1 - 0.013 15.3 0.0 0.04 13.7 0.0 1.8 1 0 0 1 1 1 0 NADH-ubiquinone reductase complex 1 MLRQ subunit HlyD_3 PF13437.6 CAV25198.1 - 0.11 13.2 2.9 3 8.6 0.1 3.2 4 0 0 4 4 4 0 HlyD family secretion protein HTH_AraC PF00165.23 CAV25204.1 - 9.1e-19 67.1 0.3 8.8e-09 35.2 0.1 2.3 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family HTH_18 PF12833.7 CAV25204.1 - 1.6e-18 66.8 0.1 3.7e-18 65.6 0.0 1.6 2 0 0 2 2 2 1 Helix-turn-helix domain Cupin_2 PF07883.11 CAV25204.1 - 0.00028 20.5 0.1 0.00046 19.9 0.1 1.3 1 0 0 1 1 1 1 Cupin domain AraC_binding PF02311.19 CAV25204.1 - 0.005 16.8 0.0 0.01 15.7 0.0 1.4 1 0 0 1 1 1 1 AraC-like ligand binding domain UPF0175 PF03683.13 CAV25204.1 - 0.0098 15.6 0.1 0.085 12.6 0.0 2.3 2 0 0 2 2 2 1 Uncharacterised protein family (UPF0175) AraC_binding_2 PF14525.6 CAV25204.1 - 0.03 14.0 0.0 0.045 13.4 0.0 1.4 1 0 0 1 1 1 0 AraC-binding-like domain Aldedh PF00171.22 CAV25207.1 - 1.6e-119 399.4 1.0 2.2e-119 399.0 1.0 1.1 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Pro_dh PF01619.18 CAV25207.1 - 2e-92 309.9 0.2 5.9e-92 308.3 0.0 1.9 2 0 0 2 2 2 1 Proline dehydrogenase Pro_dh-DNA_bdg PF14850.6 CAV25207.1 - 6.6e-47 158.7 0.4 1.8e-46 157.2 0.4 1.8 1 0 0 1 1 1 1 DNA-binding domain of Proline dehydrogenase PRODH PF18327.1 CAV25207.1 - 9.2e-06 25.8 0.0 3.5e-05 23.9 0.0 2.0 1 0 0 1 1 1 1 Proline utilization A proline dehydrogenase N-terminal domain Aldedh PF00171.22 CAV25209.1 - 0.0027 16.3 1.2 0.016 13.7 0.3 1.9 2 0 0 2 2 2 2 Aldehyde dehydrogenase family SSF PF00474.17 CAV25211.1 - 1.3e-106 356.9 23.0 2e-106 356.3 23.0 1.3 1 0 0 1 1 1 1 Sodium:solute symporter family DUF3959 PF13105.6 CAV25211.1 - 0.15 11.5 1.8 0.29 10.6 0.7 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3959) Ribosomal_L33 PF00471.20 CAV25213.1 - 0.021 15.2 3.9 0.27 11.7 0.3 2.3 2 0 0 2 2 2 0 Ribosomal protein L33 MLVIN_C PF18697.1 CAV25215.1 - 0.015 15.4 0.0 0.015 15.3 0.0 1.1 1 0 0 1 1 1 0 Murine leukemia virus (MLV) integrase (IN) C-terminal domain AsnC_trans_reg PF01037.21 CAV25216.1 - 1.5e-23 82.6 0.1 2.6e-23 81.8 0.1 1.4 1 0 0 1 1 1 1 Lrp/AsnC ligand binding domain HTH_24 PF13412.6 CAV25216.1 - 1.6e-14 53.2 0.2 3.2e-14 52.2 0.1 1.6 2 0 0 2 2 2 1 Winged helix-turn-helix DNA-binding HTH_AsnC-type PF13404.6 CAV25216.1 - 1.3e-12 47.4 0.3 2.1e-12 46.6 0.3 1.4 1 0 0 1 1 1 1 AsnC-type helix-turn-helix domain MarR PF01047.22 CAV25216.1 - 2.9e-06 27.1 0.0 5.7e-06 26.2 0.0 1.4 1 0 0 1 1 1 1 MarR family HTH_20 PF12840.7 CAV25216.1 - 8.6e-05 22.5 0.0 0.00014 21.8 0.0 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_34 PF13601.6 CAV25216.1 - 0.0014 18.8 0.0 0.0024 18.0 0.0 1.3 1 0 0 1 1 1 1 Winged helix DNA-binding domain DDRGK PF09756.9 CAV25216.1 - 0.0024 17.5 0.0 0.0046 16.6 0.0 1.4 1 0 0 1 1 1 1 DDRGK domain MarR_2 PF12802.7 CAV25216.1 - 0.0054 16.6 0.0 0.0083 16.0 0.0 1.3 1 0 0 1 1 1 1 MarR family LexA_DNA_bind PF01726.16 CAV25216.1 - 0.0055 16.4 0.0 0.012 15.4 0.0 1.5 1 1 0 1 1 1 1 LexA DNA binding domain E3_UFM1_ligase PF09743.9 CAV25216.1 - 0.0071 16.0 0.0 0.0076 15.9 0.0 1.2 1 0 0 1 1 1 1 E3 UFM1-protein ligase 1 TrmB PF01978.19 CAV25216.1 - 0.015 15.2 0.0 0.037 13.9 0.0 1.7 2 0 0 2 2 2 0 Sugar-specific transcriptional regulator TrmB HTH_27 PF13463.6 CAV25216.1 - 0.048 14.2 0.1 0.074 13.6 0.1 1.3 1 0 0 1 1 1 0 Winged helix DNA-binding domain HTH_5 PF01022.20 CAV25216.1 - 0.076 12.9 0.0 0.14 12.0 0.0 1.4 1 0 0 1 1 1 0 Bacterial regulatory protein, arsR family DUF445 PF04286.12 CAV25218.1 - 5.4e-17 62.7 1.9 4.2e-08 33.4 0.7 2.1 1 1 0 2 2 2 2 Protein of unknown function (DUF445) COMPASS-Shg1 PF05205.12 CAV25218.1 - 0.3 11.8 2.2 0.36 11.6 0.9 1.8 2 0 0 2 2 2 0 COMPASS (Complex proteins associated with Set1p) component shg1 Cauli_DNA-bind PF03310.13 CAV25218.1 - 0.58 10.2 3.3 8.5 6.5 2.4 2.1 2 0 0 2 2 2 0 Caulimovirus DNA-binding protein DUF3040 PF11239.8 CAV25218.1 - 7 7.0 5.7 22 5.4 0.5 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF3040) ABC_tran PF00005.27 CAV25220.1 - 1.6e-34 119.4 0.1 2.6e-34 118.7 0.1 1.4 1 0 0 1 1 1 1 ABC transporter ABC_membrane PF00664.23 CAV25220.1 - 3e-19 69.7 13.9 4.6e-19 69.1 13.9 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region SMC_N PF02463.19 CAV25220.1 - 5.2e-07 29.3 0.3 1.9e-06 27.5 0.3 1.8 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain RsgA_GTPase PF03193.16 CAV25220.1 - 7.8e-05 22.6 0.1 0.00014 21.8 0.1 1.4 1 0 0 1 1 1 1 RsgA GTPase MMR_HSR1 PF01926.23 CAV25220.1 - 0.0003 20.8 0.1 0.00062 19.8 0.1 1.7 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_29 PF13555.6 CAV25220.1 - 0.0037 17.0 0.1 0.012 15.4 0.1 1.8 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_22 PF13401.6 CAV25220.1 - 0.004 17.4 0.1 0.037 14.3 0.1 2.2 1 1 0 1 1 1 1 AAA domain AAA_21 PF13304.6 CAV25220.1 - 0.043 13.6 0.2 0.5 10.1 0.0 2.1 1 1 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_16 PF13191.6 CAV25220.1 - 0.048 14.1 0.3 0.1 13.0 0.3 1.5 1 1 0 1 1 1 0 AAA ATPase domain AAA_7 PF12775.7 CAV25220.1 - 0.09 12.3 0.0 0.16 11.5 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region Septin PF00735.18 CAV25220.1 - 0.11 11.8 0.0 0.18 11.1 0.0 1.2 1 0 0 1 1 1 0 Septin AAA_24 PF13479.6 CAV25220.1 - 0.14 11.9 0.0 0.36 10.5 0.0 1.8 1 1 0 1 1 1 0 AAA domain Amidinotransf PF02274.17 CAV25222.1 - 6.9e-62 209.5 2.0 1.3e-54 185.6 0.0 2.0 1 1 1 2 2 2 2 Amidinotransferase Palm_thioest PF02089.15 CAV25224.1 - 3.8e-05 23.7 0.0 4.6e-05 23.4 0.0 1.3 1 1 0 1 1 1 1 Palmitoyl protein thioesterase Hydrolase_4 PF12146.8 CAV25224.1 - 0.0003 20.2 0.0 0.011 15.0 0.0 2.2 2 0 0 2 2 2 1 Serine aminopeptidase, S33 DUF676 PF05057.14 CAV25224.1 - 0.00038 20.0 0.2 0.0032 17.0 0.2 2.0 1 1 0 1 1 1 1 Putative serine esterase (DUF676) PGAP1 PF07819.13 CAV25224.1 - 0.002 17.9 0.0 0.0031 17.3 0.0 1.3 1 0 0 1 1 1 1 PGAP1-like protein Abhydrolase_1 PF00561.20 CAV25224.1 - 0.0022 17.7 0.1 0.0053 16.4 0.1 1.7 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CAV25224.1 - 0.0055 17.3 0.0 0.0098 16.5 0.0 1.4 1 1 0 1 1 1 1 Alpha/beta hydrolase family AbiH PF14253.6 CAV25224.1 - 0.067 13.0 0.1 0.092 12.6 0.1 1.2 1 0 0 1 1 1 0 Bacteriophage abortive infection AbiH DUF5598 PF18127.1 CAV25224.1 - 0.068 13.6 0.4 0.27 11.7 0.1 2.0 2 1 0 2 2 2 0 Domain of unknown function (DUF5598) LCAT PF02450.15 CAV25224.1 - 0.071 12.3 0.0 0.11 11.6 0.0 1.3 1 1 0 1 1 1 0 Lecithin:cholesterol acyltransferase HTH_18 PF12833.7 CAV25226.1 - 2.5e-13 50.1 0.0 4.2e-13 49.4 0.0 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 CAV25226.1 - 8.8e-10 38.4 0.0 0.00018 21.5 0.0 2.4 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family Acetyltransf_19 PF18015.1 CAV25228.1 - 2.3e-34 118.0 0.1 5.2e-34 116.9 0.0 1.6 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 CAV25228.1 - 6.6e-09 36.0 0.0 5.7e-08 33.0 0.0 2.2 2 1 0 2 2 2 1 Acetyltransferase (GNAT) family Acetyltransf_3 PF13302.7 CAV25228.1 - 2.1e-05 25.2 0.1 3.7e-05 24.4 0.1 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 CAV25228.1 - 0.00065 20.1 0.1 0.0061 17.0 0.0 2.3 2 1 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 CAV25228.1 - 0.0012 18.8 0.0 0.032 14.2 0.0 2.3 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 CAV25228.1 - 0.035 14.1 0.0 0.076 13.0 0.0 1.5 1 0 0 1 1 1 0 FR47-like protein Acetyltransf_9 PF13527.7 CAV25228.1 - 0.047 13.8 0.0 1.1 9.3 0.0 2.9 3 1 0 3 3 3 0 Acetyltransferase (GNAT) domain EptA_B_N PF08019.12 CAV25230.1 - 3.3e-48 163.4 7.8 3.3e-48 163.4 7.8 1.8 2 0 0 2 2 2 1 Phosphoethanolamine transferase EptA/EptB Sulfatase PF00884.23 CAV25230.1 - 4.2e-44 151.2 1.1 5.4e-44 150.8 1.1 1.1 1 0 0 1 1 1 1 Sulfatase OMP_b-brl PF13505.6 CAV25231.1 - 1.2e-23 84.2 15.2 1.5e-23 83.8 15.2 1.1 1 0 0 1 1 1 1 Outer membrane protein beta-barrel domain OmpA_membrane PF01389.17 CAV25231.1 - 9.7e-09 35.2 4.3 1.6e-08 34.5 4.3 1.4 1 1 0 1 1 1 1 OmpA-like transmembrane domain Legionella_OMP PF05150.12 CAV25231.1 - 0.003 16.5 0.4 0.0034 16.3 0.4 1.1 1 0 0 1 1 1 1 Legionella pneumophila major outer membrane protein precursor Isochorismatase PF00857.20 CAV25233.1 - 4.5e-31 108.4 0.1 5.4e-31 108.1 0.1 1.1 1 0 0 1 1 1 1 Isochorismatase family HTH_6 PF01418.17 CAV25236.1 - 3.7e-15 55.7 0.1 8.2e-15 54.6 0.1 1.6 1 0 0 1 1 1 1 Helix-turn-helix domain, rpiR family SIS PF01380.22 CAV25236.1 - 1.6e-14 53.9 0.1 2.4e-14 53.3 0.1 1.3 1 0 0 1 1 1 1 SIS domain SIS_2 PF13580.6 CAV25236.1 - 5e-07 29.8 1.3 1.5e-05 25.0 0.1 2.6 1 1 1 2 2 2 1 SIS domain ACD PF16671.5 CAV25236.1 - 0.053 11.8 0.0 0.079 11.3 0.0 1.3 1 0 0 1 1 1 0 Actin cross-linking domain SpoU_methylas_C PF12105.8 CAV25236.1 - 0.064 12.9 0.0 0.14 11.8 0.0 1.6 1 0 0 1 1 1 0 SpoU, rRNA methylase, C-terminal MarR PF01047.22 CAV25236.1 - 0.075 13.0 0.1 0.35 10.8 0.0 2.1 2 0 0 2 2 2 0 MarR family D-ser_dehydrat PF14031.6 CAV25237.1 - 3.1e-15 56.6 0.0 8e-15 55.3 0.0 1.8 1 0 0 1 1 1 1 Putative serine dehydratase domain Ala_racemase_N PF01168.20 CAV25237.1 - 6.3e-15 55.4 0.0 8.5e-15 55.0 0.0 1.2 1 0 0 1 1 1 1 Alanine racemase, N-terminal domain RE_NgoBV PF09564.10 CAV25237.1 - 0.023 14.1 0.0 0.038 13.4 0.0 1.3 1 0 0 1 1 1 0 NgoBV restriction endonuclease Amidohydro_3 PF07969.11 CAV25239.1 - 3e-38 132.5 0.2 4e-38 132.1 0.2 1.2 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_1 PF01979.20 CAV25239.1 - 1.9e-07 30.7 3.1 0.012 14.9 0.0 2.8 2 1 0 2 2 2 2 Amidohydrolase family Urease_alpha PF00449.20 CAV25239.1 - 0.021 15.2 0.1 0.051 13.9 0.1 1.7 1 0 0 1 1 1 0 Urease alpha-subunit, N-terminal domain RPA_C PF08784.11 CAV25239.1 - 0.057 14.1 0.4 9.7 6.9 0.3 2.8 2 1 0 2 2 2 0 Replication protein A C terminal DUF3494 PF11999.8 CAV25239.1 - 0.079 12.6 2.7 0.24 11.0 0.2 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3494) Ribonuc_L-PSP PF01042.21 CAV25241.1 - 2.4e-21 76.0 0.0 3.1e-21 75.6 0.0 1.0 1 0 0 1 1 1 1 Endoribonuclease L-PSP SSF PF00474.17 CAV25242.1 - 1.6e-43 149.1 39.3 2.2e-43 148.6 39.3 1.2 1 0 0 1 1 1 1 Sodium:solute symporter family PfkB PF00294.24 CAV25244.1 - 2.8e-49 168.0 0.0 3.4e-49 167.8 0.0 1.0 1 0 0 1 1 1 1 pfkB family carbohydrate kinase Aldolase PF01081.19 CAV25246.1 - 8.1e-76 253.8 0.5 9.3e-76 253.6 0.5 1.0 1 0 0 1 1 1 1 KDPG and KHG aldolase Glyco_hydro_20 PF00728.22 CAV25247.1 - 7.9e-105 351.1 0.1 3e-102 342.6 0.1 2.4 1 1 0 1 1 1 1 Glycosyl hydrolase family 20, catalytic domain Glyco_hydro_20b PF02838.15 CAV25247.1 - 7.3e-15 55.8 3.9 1e-14 55.3 0.2 3.1 4 0 0 4 4 4 1 Glycosyl hydrolase family 20, domain 2 Glycohydro_20b2 PF14845.6 CAV25247.1 - 3.3e-08 34.3 0.1 1.5e-07 32.2 0.1 2.2 1 1 0 1 1 1 1 beta-acetyl hexosaminidase like HDPD PF02924.14 CAV25247.1 - 6.7 6.8 8.6 20 5.3 8.6 1.8 1 1 0 1 1 1 0 Bacteriophage lambda head decoration protein D Lambda_Bor PF06291.11 CAV25249.1 - 1.4e-32 111.5 0.2 1.7e-32 111.3 0.2 1.1 1 0 0 1 1 1 1 Bor protein DUF2749 PF10907.8 CAV25249.1 - 0.012 15.7 0.1 0.018 15.2 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2749) DUF898 PF05987.13 CAV25249.1 - 0.058 12.4 0.0 0.2 10.7 0.0 1.7 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF898) Dr_adhesin PF12393.8 CAV25249.1 - 0.14 12.5 1.8 0.27 11.6 1.8 1.5 1 0 0 1 1 1 0 Dr family adhesin DUF2700 PF10912.8 CAV25249.1 - 0.16 12.0 0.4 2.4 8.2 0.4 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF2700) HATPase_c PF02518.26 CAV25251.1 - 8.6e-20 71.3 0.0 1.9e-19 70.2 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 CAV25251.1 - 3.2e-13 49.5 0.1 1.1e-12 47.8 0.1 2.0 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain HAMP PF00672.25 CAV25251.1 - 7.9e-09 35.8 0.8 3.8e-08 33.6 0.0 2.5 3 0 0 3 3 3 1 HAMP domain HATPase_c_5 PF14501.6 CAV25251.1 - 4.9e-06 26.4 0.0 1.3e-05 25.0 0.0 1.7 1 0 0 1 1 1 1 GHKL domain HATPase_c_3 PF13589.6 CAV25251.1 - 5e-05 23.1 0.1 0.00011 22.0 0.1 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_2 PF13581.6 CAV25251.1 - 0.15 12.0 0.0 0.43 10.5 0.0 1.8 1 0 0 1 1 1 0 Histidine kinase-like ATPase domain Response_reg PF00072.24 CAV25253.1 - 5.8e-23 81.2 2.0 8.1e-23 80.7 1.4 1.5 2 0 0 2 2 2 1 Response regulator receiver domain Trans_reg_C PF00486.28 CAV25253.1 - 2.1e-18 66.2 0.3 5.7e-18 64.8 0.0 1.8 2 0 0 2 2 2 1 Transcriptional regulatory protein, C terminal EAL PF00563.20 CAV25255.1 - 6.9e-71 238.5 0.6 1.3e-70 237.7 0.2 1.7 2 0 0 2 2 2 1 EAL domain GGDEF PF00990.21 CAV25255.1 - 4.3e-30 104.6 0.2 8.9e-30 103.6 0.2 1.5 1 0 0 1 1 1 1 Diguanylate cyclase, GGDEF domain DUF3365 PF11845.8 CAV25255.1 - 2e-15 57.4 0.0 5.7e-15 56.0 0.0 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF3365) AtuA PF07287.11 CAV25255.1 - 0.031 13.0 0.0 0.058 12.1 0.0 1.4 1 0 0 1 1 1 0 Acyclic terpene utilisation family protein AtuA Cytochrome_CBB3 PF13442.6 CAV25255.1 - 0.056 13.8 0.0 0.14 12.4 0.0 1.7 1 0 0 1 1 1 0 Cytochrome C oxidase, cbb3-type, subunit III Doppel PF11466.8 CAV25255.1 - 0.061 13.0 0.4 0.14 11.8 0.4 1.7 1 0 0 1 1 1 0 Prion-like protein Doppel Phage_integrase PF00589.22 CAV25255.1 - 0.13 12.0 0.0 0.43 10.4 0.0 1.8 1 0 0 1 1 1 0 Phage integrase family HAMP PF00672.25 CAV25255.1 - 0.14 12.6 0.0 0.28 11.6 0.0 1.6 1 0 0 1 1 1 0 HAMP domain SAM_Exu PF18609.1 CAV25258.1 - 0.21 11.7 0.7 1.7 8.8 0.0 2.6 3 0 0 3 3 3 0 Exuperantia SAM-like domain PALP PF00291.25 CAV25260.1 - 5e-65 219.8 0.5 5.9e-65 219.6 0.5 1.0 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme AsnC_trans_reg PF01037.21 CAV25262.1 - 5.2e-17 61.6 0.1 8.4e-17 60.9 0.1 1.3 1 0 0 1 1 1 1 Lrp/AsnC ligand binding domain HTH_24 PF13412.6 CAV25262.1 - 9.1e-14 50.7 0.1 1.4e-13 50.2 0.1 1.3 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding HTH_AsnC-type PF13404.6 CAV25262.1 - 3.5e-13 49.1 0.1 5.6e-13 48.5 0.1 1.3 1 0 0 1 1 1 1 AsnC-type helix-turn-helix domain HTH_5 PF01022.20 CAV25262.1 - 1.4e-05 24.8 0.0 2.6e-05 24.0 0.0 1.4 1 0 0 1 1 1 1 Bacterial regulatory protein, arsR family MarR_2 PF12802.7 CAV25262.1 - 1.7e-05 24.6 0.1 2.5e-05 24.1 0.1 1.3 1 0 0 1 1 1 1 MarR family HTH_11 PF08279.12 CAV25262.1 - 5.6e-05 23.0 0.1 8.7e-05 22.4 0.1 1.3 1 0 0 1 1 1 1 HTH domain HTH_Crp_2 PF13545.6 CAV25262.1 - 0.00037 20.4 0.0 0.00065 19.6 0.0 1.3 1 0 0 1 1 1 1 Crp-like helix-turn-helix domain MarR PF01047.22 CAV25262.1 - 0.00083 19.2 0.0 0.0014 18.5 0.0 1.3 1 0 0 1 1 1 1 MarR family LexA_DNA_bind PF01726.16 CAV25262.1 - 0.0012 18.6 0.0 0.0021 17.8 0.0 1.4 1 0 0 1 1 1 1 LexA DNA binding domain HTH_28 PF13518.6 CAV25262.1 - 0.0021 18.2 0.0 0.0033 17.5 0.0 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain Rrf2 PF02082.20 CAV25262.1 - 0.0035 17.7 0.1 0.0062 16.9 0.1 1.3 1 0 0 1 1 1 1 Transcriptional regulator Fe_dep_repress PF01325.19 CAV25262.1 - 0.0044 17.2 0.0 0.0075 16.5 0.0 1.3 1 0 0 1 1 1 1 Iron dependent repressor, N-terminal DNA binding domain RepL PF05732.11 CAV25262.1 - 0.0048 16.3 0.1 0.0082 15.6 0.0 1.4 1 1 0 1 1 1 1 Firmicute plasmid replication protein (RepL) TrmB PF01978.19 CAV25262.1 - 0.0062 16.4 0.1 0.01 15.7 0.1 1.3 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB GYD PF08734.11 CAV25262.1 - 0.011 15.6 0.0 0.024 14.6 0.0 1.6 1 0 0 1 1 1 0 GYD domain HTH_29 PF13551.6 CAV25262.1 - 0.014 15.4 0.0 0.022 14.8 0.0 1.3 1 0 0 1 1 1 0 Winged helix-turn helix HTH_23 PF13384.6 CAV25262.1 - 0.016 15.0 0.0 0.025 14.4 0.0 1.3 1 0 0 1 1 1 0 Homeodomain-like domain Sigma70_r4_2 PF08281.12 CAV25262.1 - 0.025 14.2 0.1 0.046 13.4 0.1 1.4 1 0 0 1 1 1 0 Sigma-70, region 4 HTH_IclR PF09339.10 CAV25262.1 - 0.029 14.2 0.0 0.043 13.6 0.0 1.3 1 0 0 1 1 1 0 IclR helix-turn-helix domain Crp PF00325.20 CAV25262.1 - 0.032 13.9 0.0 0.057 13.1 0.0 1.4 1 0 0 1 1 1 0 Bacterial regulatory proteins, crp family HTH_10 PF04967.12 CAV25262.1 - 0.032 14.0 0.1 0.067 13.0 0.1 1.5 1 0 0 1 1 1 0 HTH DNA binding domain HTH_50 PF18024.1 CAV25262.1 - 0.047 13.3 0.0 0.11 12.1 0.0 1.6 1 1 0 1 1 1 0 Helix-turn-helix domain HTH_41 PF14502.6 CAV25262.1 - 0.078 12.7 0.0 0.17 11.6 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_Mga PF08280.11 CAV25262.1 - 0.1 12.7 0.0 0.21 11.6 0.0 1.5 1 0 0 1 1 1 0 M protein trans-acting positive regulator (MGA) HTH domain HTH_DeoR PF08220.12 CAV25262.1 - 0.13 12.0 0.1 0.2 11.4 0.1 1.3 1 0 0 1 1 1 0 DeoR-like helix-turn-helix domain Amdase PF17645.1 CAV25264.1 - 4.5e-19 68.9 0.0 5.7e-19 68.6 0.0 1.1 1 0 0 1 1 1 1 Arylmalonate decarboxylase Asp_Glu_race PF01177.22 CAV25264.1 - 1e-06 28.8 0.4 3.6e-06 27.0 0.3 1.9 1 1 0 1 1 1 1 Asp/Glu/Hydantoin racemase AroM PF07302.11 CAV25264.1 - 0.0012 18.3 0.0 0.0017 17.8 0.0 1.3 1 0 0 1 1 1 1 AroM protein Peripla_BP_6 PF13458.6 CAV25264.1 - 0.1 12.2 0.1 0.16 11.6 0.1 1.3 1 0 0 1 1 1 0 Periplasmic binding protein Peptidase_M20 PF01546.28 CAV25266.1 - 3e-30 105.5 0.1 3.7e-30 105.2 0.1 1.1 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 CAV25266.1 - 1.2e-07 31.6 0.7 6.7e-07 29.2 0.0 2.2 2 0 0 2 2 2 1 Peptidase dimerisation domain DctP PF03480.13 CAV25267.1 - 5e-64 216.4 0.8 6.5e-64 216.0 0.8 1.1 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein, family 7 OST3_OST6 PF04756.13 CAV25267.1 - 0.098 12.0 0.4 0.19 11.0 0.0 1.6 2 0 0 2 2 2 0 OST3 / OST6 family, transporter family DctQ PF04290.12 CAV25269.1 - 2e-28 98.9 6.1 2e-28 98.9 6.1 1.4 2 0 0 2 2 2 1 Tripartite ATP-independent periplasmic transporters, DctQ component DctM PF06808.12 CAV25271.1 - 1.6e-94 317.1 43.5 1.9e-94 316.8 43.5 1.0 1 0 0 1 1 1 1 Tripartite ATP-independent periplasmic transporter, DctM component CitMHS PF03600.16 CAV25271.1 - 0.00019 20.7 42.2 0.034 13.3 19.8 2.3 2 1 0 2 2 2 2 Citrate transporter Peptidase_M24 PF00557.24 CAV25273.1 - 1.9e-38 132.3 0.1 3e-38 131.6 0.1 1.3 1 0 0 1 1 1 1 Metallopeptidase family M24 Creatinase_N PF01321.18 CAV25273.1 - 4.1e-15 56.6 0.0 7.9e-15 55.7 0.0 1.5 1 0 0 1 1 1 1 Creatinase/Prolidase N-terminal domain TetR_C_6 PF13977.6 CAV25275.1 - 3e-30 104.8 0.0 1.5e-29 102.6 0.0 1.8 1 1 1 2 2 2 2 BetI-type transcriptional repressor, C-terminal TetR_N PF00440.23 CAV25275.1 - 1.9e-11 43.6 0.0 3.9e-11 42.6 0.0 1.6 1 0 0 1 1 1 1 Bacterial regulatory proteins, tetR family Cullin_Nedd8 PF10557.9 CAV25275.1 - 0.08 13.0 0.1 0.47 10.5 0.0 2.1 2 0 0 2 2 2 0 Cullin protein neddylation domain DUF4085 PF13315.6 CAV25275.1 - 0.1 12.2 0.0 0.15 11.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4085) Aldedh PF00171.22 CAV25277.1 - 8.1e-176 585.1 0.3 9.1e-176 584.9 0.3 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family LuxC PF05893.14 CAV25277.1 - 0.1 11.6 0.0 0.17 10.9 0.0 1.3 1 0 0 1 1 1 0 Acyl-CoA reductase (LuxC) GMC_oxred_N PF00732.19 CAV25279.1 - 1.3e-87 294.0 0.2 3.4e-87 292.6 0.1 1.7 2 0 0 2 2 2 1 GMC oxidoreductase GMC_oxred_C PF05199.13 CAV25279.1 - 1.5e-40 139.0 0.0 2.5e-40 138.3 0.0 1.4 1 0 0 1 1 1 1 GMC oxidoreductase FAD_binding_2 PF00890.24 CAV25279.1 - 0.0001 21.5 0.4 0.036 13.2 0.1 2.1 2 0 0 2 2 2 2 FAD binding domain Lycopene_cycl PF05834.12 CAV25279.1 - 0.00089 18.4 0.0 0.0013 17.9 0.0 1.2 1 0 0 1 1 1 1 Lycopene cyclase protein NAD_binding_8 PF13450.6 CAV25279.1 - 0.0028 17.9 0.7 0.0075 16.5 0.7 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 CAV25279.1 - 0.0028 16.9 0.1 0.016 14.5 0.0 1.9 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 CAV25279.1 - 0.0071 16.0 0.3 0.021 14.5 0.3 1.8 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 CAV25279.1 - 0.12 11.6 0.0 0.22 10.8 0.0 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase OpuAC PF04069.12 CAV25281.1 - 7.4e-60 202.7 0.3 7.4e-60 202.7 0.3 1.4 2 0 0 2 2 2 1 Substrate binding domain of ABC-type glycine betaine transport system DELLA PF12041.8 CAV25281.1 - 0.15 12.0 0.8 4.7 7.2 0.3 2.7 2 1 0 2 2 2 0 Transcriptional regulator DELLA protein N terminal BPD_transp_1 PF00528.22 CAV25283.1 - 7.6e-26 91.0 13.6 7.6e-26 91.0 13.6 2.2 2 0 0 2 2 2 1 Binding-protein-dependent transport system inner membrane component ABC_tran PF00005.27 CAV25284.1 - 7e-28 97.9 0.0 1.3e-27 97.0 0.0 1.5 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 CAV25284.1 - 1e-07 32.1 0.5 0.003 17.4 0.1 2.2 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system RsgA_GTPase PF03193.16 CAV25284.1 - 0.00079 19.4 0.3 0.0015 18.5 0.3 1.4 1 0 0 1 1 1 1 RsgA GTPase AAA_29 PF13555.6 CAV25284.1 - 0.0021 17.7 0.1 0.0066 16.2 0.1 1.8 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_16 PF13191.6 CAV25284.1 - 0.0039 17.6 0.3 0.0081 16.6 0.3 1.7 1 1 0 1 1 1 1 AAA ATPase domain SMC_N PF02463.19 CAV25284.1 - 0.016 14.7 0.3 0.074 12.5 0.3 1.9 1 1 0 1 1 1 0 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 CAV25284.1 - 0.029 14.6 0.2 0.077 13.3 0.2 1.8 1 1 0 1 1 1 0 AAA domain CBS PF00571.28 CAV25284.1 - 0.034 14.6 0.1 0.41 11.1 0.0 2.4 2 0 0 2 2 2 0 CBS domain ABC_ATPase PF09818.9 CAV25284.1 - 0.036 12.9 0.2 0.44 9.3 0.0 2.0 2 0 0 2 2 2 0 Predicted ATPase of the ABC class AAA_30 PF13604.6 CAV25284.1 - 0.099 12.3 0.2 0.39 10.4 0.0 2.0 2 1 0 2 2 2 0 AAA domain HTH_7 PF02796.15 CAV25284.1 - 0.16 12.1 0.0 0.37 10.9 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain of resolvase MarR PF01047.22 CAV25286.1 - 1.5e-15 56.8 0.4 3.2e-15 55.8 0.4 1.6 1 0 0 1 1 1 1 MarR family HTH_27 PF13463.6 CAV25286.1 - 6e-12 45.9 0.5 1.2e-11 45.0 0.2 1.6 2 0 0 2 2 1 1 Winged helix DNA-binding domain MarR_2 PF12802.7 CAV25286.1 - 1.6e-10 40.7 0.0 2.9e-10 39.9 0.0 1.4 1 0 0 1 1 1 1 MarR family HTH_24 PF13412.6 CAV25286.1 - 1.5e-07 30.8 0.2 4.4e-07 29.4 0.2 1.8 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding HTH_34 PF13601.6 CAV25286.1 - 1.3e-05 25.3 0.1 3.3e-05 24.0 0.0 1.7 2 0 0 2 2 2 1 Winged helix DNA-binding domain TrmB PF01978.19 CAV25286.1 - 8e-05 22.4 0.0 0.00013 21.8 0.0 1.4 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB Fe_dep_repress PF01325.19 CAV25286.1 - 0.00033 20.8 0.1 0.00069 19.8 0.1 1.5 1 0 0 1 1 1 1 Iron dependent repressor, N-terminal DNA binding domain HxlR PF01638.17 CAV25286.1 - 0.00066 19.5 0.4 0.0017 18.2 0.3 1.6 1 1 0 1 1 1 1 HxlR-like helix-turn-helix Penicillinase_R PF03965.16 CAV25286.1 - 0.00067 20.0 0.3 0.0009 19.6 0.3 1.5 1 1 0 1 1 1 1 Penicillinase repressor Replic_Relax PF13814.6 CAV25286.1 - 0.0015 18.7 0.1 0.0018 18.3 0.1 1.1 1 0 0 1 1 1 1 Replication-relaxation HTH_IclR PF09339.10 CAV25286.1 - 0.0022 17.7 0.0 0.0049 16.6 0.0 1.6 1 0 0 1 1 1 1 IclR helix-turn-helix domain HTH_11 PF08279.12 CAV25286.1 - 0.0027 17.6 0.4 0.0074 16.2 0.4 1.7 1 0 0 1 1 1 1 HTH domain Rrf2 PF02082.20 CAV25286.1 - 0.0044 17.3 0.2 0.01 16.1 0.1 1.7 1 1 0 1 1 1 1 Transcriptional regulator DUF3116 PF11313.8 CAV25286.1 - 0.0056 16.5 0.1 0.013 15.4 0.1 1.7 1 1 0 1 1 1 1 Protein of unknown function (DUF3116) PadR PF03551.14 CAV25286.1 - 0.0057 16.6 0.1 0.01 15.8 0.1 1.4 1 0 0 1 1 1 1 Transcriptional regulator PadR-like family HTH_6 PF01418.17 CAV25286.1 - 0.011 15.8 0.0 0.025 14.6 0.0 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain, rpiR family HTH_5 PF01022.20 CAV25286.1 - 0.017 15.0 0.0 0.034 14.0 0.0 1.5 1 0 0 1 1 1 0 Bacterial regulatory protein, arsR family FeoC PF09012.10 CAV25286.1 - 0.02 15.0 0.0 0.043 13.9 0.0 1.5 1 0 0 1 1 1 0 FeoC like transcriptional regulator HTH_45 PF14947.6 CAV25286.1 - 0.022 14.7 0.1 0.059 13.4 0.1 1.8 1 1 0 1 1 1 0 Winged helix-turn-helix HTH_DeoR PF08220.12 CAV25286.1 - 0.05 13.4 0.3 0.11 12.3 0.3 1.6 1 0 0 1 1 1 0 DeoR-like helix-turn-helix domain HTH_AsnC-type PF13404.6 CAV25286.1 - 0.074 12.9 0.0 0.22 11.4 0.0 1.9 1 0 0 1 1 1 0 AsnC-type helix-turn-helix domain Pentapeptide PF00805.22 CAV25288.1 - 9.7e-26 89.0 20.8 8.8e-09 34.8 6.6 5.9 3 1 1 6 6 6 6 Pentapeptide repeats (8 copies) Pentapeptide_4 PF13599.6 CAV25288.1 - 1.2e-19 70.3 14.7 6.3e-11 42.3 13.4 3.6 1 1 2 3 3 3 2 Pentapeptide repeats (9 copies) Pentapeptide_3 PF13576.6 CAV25288.1 - 2e-15 56.7 11.8 7e-05 22.9 7.6 4.7 2 1 1 4 4 4 4 Pentapeptide repeats (9 copies) DUF2678 PF10856.8 CAV25290.1 - 0.0037 17.2 4.5 0.0044 16.9 4.5 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2678) DUF962 PF06127.11 CAV25290.1 - 0.12 12.5 2.3 0.16 12.0 2.3 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF962) PIG-U PF06728.13 CAV25290.1 - 0.23 10.5 5.4 0.24 10.4 5.4 1.0 1 0 0 1 1 1 0 GPI transamidase subunit PIG-U DUF2207 PF09972.9 CAV25290.1 - 2.6 6.7 3.3 2.6 6.7 3.3 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF5062 PF16691.5 CAV25292.1 - 7.4e-27 93.3 0.4 8.3e-27 93.2 0.4 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF5062) Acetyltransf_1 PF00583.25 CAV25293.1 - 5e-13 49.3 0.0 6.9e-13 48.9 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 CAV25293.1 - 0.0001 22.7 0.0 0.00016 22.0 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.7 CAV25293.1 - 0.0021 18.7 0.0 0.003 18.2 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 CAV25293.1 - 0.0039 17.1 0.0 0.0058 16.6 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_15 PF17013.5 CAV25293.1 - 0.013 15.0 0.0 0.015 14.8 0.0 1.2 1 0 0 1 1 1 0 Putative acetyl-transferase Aminotran_3 PF00202.21 CAV25295.1 - 2.6e-80 270.1 0.0 3.1e-80 269.8 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III Aminotran_1_2 PF00155.21 CAV25295.1 - 0.0048 16.1 0.0 0.041 13.1 0.0 2.0 1 1 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.21 CAV25295.1 - 0.018 14.3 0.0 0.028 13.7 0.0 1.2 1 0 0 1 1 1 0 Beta-eliminating lyase Ectoine_synth PF06339.12 CAV25297.1 - 9.7e-61 203.6 0.6 1.1e-60 203.5 0.6 1.0 1 0 0 1 1 1 1 Ectoine synthase Cupin_2 PF07883.11 CAV25297.1 - 7.3e-10 38.4 0.3 1e-09 38.0 0.3 1.2 1 0 0 1 1 1 1 Cupin domain AraC_binding PF02311.19 CAV25297.1 - 2.8e-05 24.0 0.4 3.8e-05 23.6 0.4 1.2 1 0 0 1 1 1 1 AraC-like ligand binding domain Cupin_3 PF05899.12 CAV25297.1 - 0.0081 15.8 0.0 0.013 15.1 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF861) Pirin_C PF05726.13 CAV25297.1 - 0.075 13.4 0.0 0.11 12.8 0.0 1.2 1 0 0 1 1 1 0 Pirin C-terminal cupin domain AA_kinase PF00696.28 CAV25299.1 - 3.6e-20 72.6 0.0 1e-19 71.1 0.0 1.8 2 0 0 2 2 2 1 Amino acid kinase family UTP25 PF06862.12 CAV25299.1 - 0.014 14.2 0.2 0.021 13.6 0.2 1.2 1 0 0 1 1 1 0 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 DUF5129 PF17173.4 CAV25299.1 - 0.059 12.5 0.0 0.086 11.9 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5129) HAD_2 PF13419.6 CAV25300.1 - 9.1e-10 38.9 0.0 1.1e-09 38.6 0.0 1.2 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 CAV25300.1 - 1.6e-06 28.5 0.0 2.8e-06 27.8 0.0 1.5 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 CAV25300.1 - 0.0046 17.0 0.0 0.0074 16.3 0.0 1.3 1 0 0 1 1 1 1 HAD-hyrolase-like DUF2608 PF11019.8 CAV25300.1 - 0.021 14.3 0.1 4.1 6.8 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2608) Hexapep PF00132.24 CAV25304.1 - 4.3e-16 57.9 8.3 9e-09 34.7 3.3 3.2 2 1 1 3 3 3 3 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 CAV25304.1 - 1e-12 47.5 9.8 3.4e-09 36.3 2.1 3.0 2 1 0 2 2 2 2 Hexapeptide repeat of succinyl-transferase Mac PF12464.8 CAV25304.1 - 2.7e-09 37.1 0.0 3.9e-09 36.6 0.0 1.3 1 0 0 1 1 1 1 Maltose acetyltransferase A_deaminase PF00962.22 CAV25306.1 - 1.1e-74 251.7 0.0 1.3e-74 251.5 0.0 1.0 1 0 0 1 1 1 1 Adenosine/AMP deaminase YmzC PF14157.6 CAV25306.1 - 0.056 13.5 0.2 0.13 12.4 0.2 1.6 1 0 0 1 1 1 0 YmzC-like protein LysR_substrate PF03466.20 CAV25308.1 - 2.1e-20 73.0 0.0 2.9e-20 72.6 0.0 1.1 1 0 0 1 1 1 1 LysR substrate binding domain HTH_1 PF00126.27 CAV25308.1 - 7.1e-16 57.9 0.0 1.2e-15 57.1 0.0 1.4 1 0 0 1 1 1 1 Bacterial regulatory helix-turn-helix protein, lysR family HTH_5 PF01022.20 CAV25308.1 - 0.0018 18.1 1.9 0.0031 17.3 1.1 1.8 2 0 0 2 2 2 1 Bacterial regulatory protein, arsR family HTH_30 PF13556.6 CAV25308.1 - 0.0019 17.9 0.0 0.0049 16.6 0.0 1.7 1 0 0 1 1 1 1 PucR C-terminal helix-turn-helix domain GSH_synth_ATP PF03917.17 CAV25310.1 - 6.7e-66 222.6 0.1 7.7e-66 222.4 0.1 1.0 1 0 0 1 1 1 1 Eukaryotic glutathione synthase, ATP binding domain GSH_synthase PF03199.15 CAV25310.1 - 3.2e-20 72.5 0.2 6.2e-20 71.6 0.2 1.5 1 0 0 1 1 1 1 Eukaryotic glutathione synthase DUF2695 PF10905.8 CAV25310.1 - 0.0066 16.6 1.7 0.028 14.6 0.1 2.4 2 0 0 2 2 2 1 Protein of unknown function (DUF2695) SgrR_N PF12793.7 CAV25311.1 - 1.5e-23 83.2 0.1 2.7e-23 82.4 0.1 1.4 1 0 0 1 1 1 1 Sugar transport-related sRNA regulator N-term SBP_bac_5 PF00496.22 CAV25311.1 - 9e-19 67.7 0.0 1.3e-18 67.1 0.0 1.2 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 5 Middle MarR_2 PF12802.7 CAV25311.1 - 0.026 14.4 0.0 0.09 12.7 0.0 1.8 2 0 0 2 2 2 0 MarR family DUF3253 PF11625.8 CAV25311.1 - 0.12 12.6 0.0 0.26 11.5 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3253) HTH_17 PF12728.7 CAV25311.1 - 0.15 12.3 0.7 2.4 8.4 0.0 2.9 3 0 0 3 3 3 0 Helix-turn-helix domain GFO_IDH_MocA PF01408.22 CAV25313.1 - 1.7e-23 83.7 0.1 3.8e-23 82.6 0.0 1.6 1 1 1 2 2 2 1 Oxidoreductase family, NAD-binding Rossmann fold NAD_binding_3 PF03447.16 CAV25313.1 - 9.9e-05 23.0 0.0 0.00016 22.3 0.0 1.3 1 0 0 1 1 1 1 Homoserine dehydrogenase, NAD binding domain F420_oxidored PF03807.17 CAV25313.1 - 0.014 16.0 0.0 0.024 15.2 0.0 1.4 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent S-methyl_trans PF02574.16 CAV25315.1 - 1.3e-51 176.0 0.0 1.5e-51 175.8 0.0 1.0 1 0 0 1 1 1 1 Homocysteine S-methyltransferase DEDD_Tnp_IS110 PF01548.17 CAV25317.1 - 0.00035 20.5 0.0 0.00043 20.2 0.0 1.1 1 0 0 1 1 1 1 Transposase DUF2318 PF10080.9 CAV25319.1 - 0.039 14.1 0.4 0.067 13.3 0.4 1.3 1 0 0 1 1 1 0 Predicted membrane protein (DUF2318) C1_2 PF03107.16 CAV25319.1 - 0.062 13.6 2.0 0.12 12.8 2.0 1.4 1 0 0 1 1 1 0 C1 domain DEDD_Tnp_IS110 PF01548.17 CAV25320.1 - 0.0022 17.9 0.0 0.0023 17.8 0.0 1.1 1 0 0 1 1 1 1 Transposase Vma12 PF11712.8 CAV25322.1 - 0.25 11.4 2.2 0.42 10.7 2.2 1.3 1 0 0 1 1 1 0 Endoplasmic reticulum-based factor for assembly of V-ATPase Pyocin_S PF06958.12 CAV25324.1 - 4.7e-18 66.1 0.0 8.5e-18 65.2 0.0 1.4 1 0 0 1 1 1 1 S-type Pyocin TLP-20 PF06088.11 CAV25324.1 - 0.0037 17.2 0.0 0.0094 15.9 0.0 1.6 1 0 0 1 1 1 1 Nucleopolyhedrovirus telokin-like protein-20 (TLP20) DUF418 PF04235.12 CAV25326.1 - 0.15 12.0 3.7 6.9 6.6 2.4 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF418) TM_helix PF05552.12 CAV25326.1 - 3.3 7.7 6.4 0.24 11.4 0.8 2.0 2 0 0 2 2 2 0 Conserved TM helix PhdYeFM_antitox PF02604.19 CAV25328.1 - 4.3e-16 58.5 0.1 5.1e-16 58.3 0.1 1.1 1 0 0 1 1 1 1 Antitoxin Phd_YefM, type II toxin-antitoxin system ParE_toxin PF05016.15 CAV25330.1 - 1.7e-13 51.0 0.0 1.8e-13 50.9 0.0 1.0 1 0 0 1 1 1 1 ParE toxin of type II toxin-antitoxin system, parDE BPL_LplA_LipB PF03099.19 CAV25332.1 - 0.066 13.1 0.0 0.1 12.5 0.0 1.3 1 0 0 1 1 1 0 Biotin/lipoate A/B protein ligase family adh_short PF00106.25 CAV25334.1 - 3.3e-31 108.3 0.0 1.4e-30 106.3 0.0 1.8 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CAV25334.1 - 4.1e-22 78.9 0.0 7e-22 78.1 0.0 1.4 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CAV25334.1 - 2.1e-11 44.1 0.1 3.2e-11 43.5 0.1 1.2 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 CAV25334.1 - 0.0039 16.4 0.2 0.0051 16.0 0.2 1.1 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein SAM_MT PF04445.13 CAV25334.1 - 0.0041 16.6 0.1 0.0062 16.0 0.1 1.2 1 0 0 1 1 1 1 Putative SAM-dependent methyltransferase NAD_binding_10 PF13460.6 CAV25334.1 - 0.015 15.2 0.1 0.023 14.6 0.1 1.3 1 0 0 1 1 1 0 NAD(P)H-binding Epimerase PF01370.21 CAV25334.1 - 0.055 12.9 0.0 0.072 12.5 0.0 1.3 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.17 CAV25334.1 - 0.063 12.4 0.0 0.1 11.6 0.0 1.3 1 0 0 1 1 1 0 RmlD substrate binding domain rve PF00665.26 CAV25336.1 - 1.8e-26 92.6 0.1 6.2e-26 90.9 0.0 1.8 2 0 0 2 2 2 1 Integrase core domain rve_3 PF13683.6 CAV25336.1 - 2.6e-19 68.8 0.0 5.3e-19 67.8 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain DDE_Tnp_IS240 PF13610.6 CAV25336.1 - 0.0001 22.5 0.2 0.00018 21.7 0.2 1.4 1 0 0 1 1 1 1 DDE domain HTH_21 PF13276.6 CAV25336.1 - 0.015 15.4 1.6 0.043 14.0 1.0 2.1 2 0 0 2 2 2 0 HTH-like domain rve_2 PF13333.6 CAV25336.1 - 0.051 13.7 0.1 0.1 12.8 0.1 1.5 1 0 0 1 1 1 0 Integrase core domain RlmM_FDX PF18125.1 CAV25336.1 - 0.13 12.8 0.0 0.47 11.0 0.0 1.9 1 0 0 1 1 1 0 RlmM ferredoxin-like domain HTH_28 PF13518.6 CAV25337.1 - 9.3e-06 25.7 0.1 2.1e-05 24.6 0.1 1.6 1 0 0 1 1 1 1 Helix-turn-helix domain Sugarporin_N PF11471.8 CAV25337.1 - 0.0042 17.0 2.1 0.0082 16.1 2.1 1.5 1 0 0 1 1 1 1 Maltoporin periplasmic N-terminal extension HTH_Tnp_1 PF01527.20 CAV25337.1 - 0.088 13.1 3.0 0.32 11.3 3.0 1.9 1 1 0 1 1 1 0 Transposase Alkyl_sulf_dimr PF14863.6 CAV25339.1 - 7.8e-51 172.2 0.3 1.6e-50 171.2 0.3 1.5 1 0 0 1 1 1 1 Alkyl sulfatase dimerisation Alkyl_sulf_C PF14864.6 CAV25339.1 - 4.1e-32 111.1 0.9 7.9e-32 110.2 0.9 1.5 1 0 0 1 1 1 1 Alkyl sulfatase C-terminal Lactamase_B PF00753.27 CAV25339.1 - 1.4e-23 83.9 0.0 5.2e-22 78.8 0.0 2.5 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 CAV25339.1 - 6.6e-05 22.5 0.0 0.00016 21.2 0.0 1.7 1 0 0 1 1 1 1 Beta-lactamase superfamily domain SCP2 PF02036.17 CAV25339.1 - 0.00043 20.7 0.1 0.0018 18.7 0.1 2.1 1 1 1 2 2 2 1 SCP-2 sterol transfer family TPR_19 PF14559.6 CAV25339.1 - 0.046 14.2 0.2 0.11 13.0 0.2 1.6 1 0 0 1 1 1 0 Tetratricopeptide repeat HTH_1 PF00126.27 CAV25341.1 - 4.9e-17 61.6 0.1 8.8e-17 60.8 0.1 1.4 1 0 0 1 1 1 1 Bacterial regulatory helix-turn-helix protein, lysR family LysR_substrate PF03466.20 CAV25341.1 - 1.2e-15 57.5 0.0 1.7e-15 57.0 0.0 1.2 1 0 0 1 1 1 1 LysR substrate binding domain EamA PF00892.20 CAV25342.1 - 2.4e-32 112.0 39.9 1.2e-16 61.1 17.9 2.1 2 0 0 2 2 2 2 EamA-like transporter family TMEM234 PF10639.9 CAV25342.1 - 0.094 12.8 13.6 1.6 8.8 1.3 3.3 2 2 0 2 2 2 0 Putative transmembrane family 234 PIRT PF15099.6 CAV25342.1 - 0.73 9.4 4.3 1 8.9 2.3 2.2 1 1 1 2 2 2 0 Phosphoinositide-interacting protein family Glyoxalase PF00903.25 CAV25344.1 - 2e-11 44.2 0.0 2.3e-11 44.0 0.0 1.1 1 0 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_4 PF13669.6 CAV25344.1 - 1.8e-08 34.7 0.0 2.2e-08 34.3 0.0 1.0 1 0 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily PepSY_2 PF13670.6 CAV25344.1 - 0.0014 18.6 0.0 0.0022 18.0 0.0 1.3 1 0 0 1 1 1 1 Peptidase propeptide and YPEB domain Glyoxalase_6 PF18029.1 CAV25344.1 - 0.016 16.0 0.0 0.023 15.5 0.0 1.3 1 1 0 1 1 1 0 Glyoxalase-like domain Glyco_hydro_1 PF00232.18 CAV25348.1 - 4.8e-136 453.8 4.4 5.4e-136 453.6 4.4 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 1 Cellulase PF00150.18 CAV25348.1 - 0.0015 18.0 0.2 0.0024 17.4 0.2 1.2 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) Peripla_BP_3 PF13377.6 CAV25349.1 - 2.1e-32 112.7 0.0 7.8e-32 110.9 0.0 1.8 2 0 0 2 2 2 1 Periplasmic binding protein-like domain Peripla_BP_4 PF13407.6 CAV25349.1 - 1.2e-24 87.3 0.0 1.6e-24 86.9 0.0 1.2 1 0 0 1 1 1 1 Periplasmic binding protein domain Peripla_BP_1 PF00532.21 CAV25349.1 - 8.9e-23 81.1 0.3 1.1e-22 80.8 0.3 1.1 1 0 0 1 1 1 1 Periplasmic binding proteins and sugar binding domain of LacI family LacI PF00356.21 CAV25349.1 - 1.1e-17 63.5 1.3 3.2e-17 62.1 0.1 2.5 3 0 0 3 3 3 1 Bacterial regulatory proteins, lacI family HTH_31 PF13560.6 CAV25349.1 - 1.8e-06 28.2 0.0 1.6e-05 25.1 0.0 2.1 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_3 PF01381.22 CAV25349.1 - 2.6e-06 27.4 0.0 6e-06 26.2 0.0 1.6 1 0 0 1 1 1 1 Helix-turn-helix Sigma54_DBD PF04552.13 CAV25349.1 - 0.021 14.6 0.1 0.04 13.6 0.1 1.5 1 0 0 1 1 1 0 Sigma-54, DNA binding domain HTH_Tnp_ISL3 PF13542.6 CAV25349.1 - 0.022 14.2 0.8 0.1 12.0 0.1 2.2 2 0 0 2 2 2 0 Helix-turn-helix domain of transposase family ISL3 HTH_Crp_2 PF13545.6 CAV25349.1 - 0.024 14.6 0.2 0.25 11.4 0.1 2.5 3 0 0 3 3 3 0 Crp-like helix-turn-helix domain HTH_IclR PF09339.10 CAV25349.1 - 0.031 14.1 0.0 0.12 12.2 0.0 2.1 1 0 0 1 1 1 0 IclR helix-turn-helix domain YdaS_antitoxin PF15943.5 CAV25349.1 - 0.041 13.8 0.0 0.12 12.3 0.0 1.7 1 0 0 1 1 1 0 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT TetR_N PF00440.23 CAV25349.1 - 0.044 13.6 0.0 0.12 12.2 0.0 1.8 1 0 0 1 1 1 0 Bacterial regulatory proteins, tetR family HTH_36 PF13730.6 CAV25349.1 - 0.051 13.5 0.0 14 5.7 0.0 2.5 2 0 0 2 2 2 0 Helix-turn-helix domain HTH_38 PF13936.6 CAV25349.1 - 0.053 13.3 0.0 0.45 10.3 0.0 2.5 3 0 0 3 3 3 0 Helix-turn-helix domain Dicty_REP PF05086.12 CAV25349.1 - 0.062 11.3 0.0 0.086 10.8 0.0 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein HTH_19 PF12844.7 CAV25349.1 - 0.094 12.7 0.0 0.29 11.2 0.0 1.9 2 0 0 2 2 2 0 Helix-turn-helix domain MarR_2 PF12802.7 CAV25349.1 - 0.18 11.7 0.0 0.54 10.2 0.0 1.8 1 0 0 1 1 1 0 MarR family Hexapep_2 PF14602.6 CAV25351.1 - 1.2e-11 44.2 12.7 4.5e-08 32.7 6.9 2.9 2 0 0 2 2 2 2 Hexapeptide repeat of succinyl-transferase Hexapep PF00132.24 CAV25351.1 - 1.9e-11 43.2 17.7 3e-09 36.2 7.0 3.5 3 1 0 3 3 3 2 Bacterial transferase hexapeptide (six repeats) Mac PF12464.8 CAV25351.1 - 5e-11 42.7 0.0 7.1e-11 42.2 0.0 1.2 1 0 0 1 1 1 1 Maltose acetyltransferase MFS_1 PF07690.16 CAV25353.1 - 1.8e-44 152.1 60.1 5.1e-43 147.4 46.1 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_4 PF06779.14 CAV25353.1 - 2e-14 53.7 41.7 2.3e-14 53.5 41.7 1.0 1 0 0 1 1 1 1 Uncharacterised MFS-type transporter YbfB Sugar_tr PF00083.24 CAV25353.1 - 6.7e-10 38.4 38.4 2.9e-08 33.0 16.4 3.2 1 1 1 3 3 3 2 Sugar (and other) transporter YrhC PF14143.6 CAV25353.1 - 0.99 9.5 6.0 2.6 8.2 0.7 3.2 1 1 1 2 2 2 0 YrhC-like protein LysR_substrate PF03466.20 CAV25355.1 - 3.2e-41 141.0 0.0 9.5e-41 139.5 0.0 1.7 2 1 0 2 2 2 1 LysR substrate binding domain HTH_1 PF00126.27 CAV25355.1 - 6.5e-16 58.0 0.6 1.8e-15 56.6 0.2 1.9 2 0 0 2 2 2 1 Bacterial regulatory helix-turn-helix protein, lysR family ABM PF03992.16 CAV25356.1 - 6.2e-14 51.9 0.1 8.2e-14 51.5 0.1 1.2 1 0 0 1 1 1 1 Antibiotic biosynthesis monooxygenase Adenyl_transf PF04439.12 CAV25360.1 - 0.00012 21.3 0.0 0.00053 19.2 0.0 2.1 1 1 0 1 1 1 1 Streptomycin adenylyltransferase NTP_transf_2 PF01909.23 CAV25360.1 - 0.00066 19.9 0.0 0.0013 19.0 0.0 1.5 1 0 0 1 1 1 1 Nucleotidyltransferase domain Polbeta PF18765.1 CAV25360.1 - 0.1 12.7 0.1 0.2 11.8 0.1 1.5 1 0 0 1 1 1 0 Polymerase beta, Nucleotidyltransferase NTP_transf_7 PF07984.12 CAV25360.1 - 0.12 11.6 0.0 0.17 11.1 0.0 1.2 1 0 0 1 1 1 0 Nucleotidyltransferase RibD_C PF01872.17 CAV25362.1 - 8.2e-18 65.0 0.2 5.4e-17 62.3 0.2 1.8 1 1 0 1 1 1 1 RibD C-terminal domain TetR_N PF00440.23 CAV25364.1 - 2e-07 30.7 0.0 3.6e-07 29.9 0.0 1.5 1 0 0 1 1 1 1 Bacterial regulatory proteins, tetR family TetR_C_1 PF02909.17 CAV25364.1 - 6.6e-06 26.0 0.0 9.7e-06 25.5 0.0 1.3 1 0 0 1 1 1 1 Tetracyclin repressor-like, C-terminal domain Glyco_tran_WbsX PF14307.6 CAV25364.1 - 0.015 14.7 0.0 0.021 14.3 0.0 1.2 1 0 0 1 1 1 0 Glycosyltransferase WbsX GP3_package PF16677.5 CAV25364.1 - 0.015 15.4 0.0 0.027 14.6 0.0 1.5 1 0 0 1 1 1 0 DNA-packaging protein gp3 LexA_DNA_bind PF01726.16 CAV25364.1 - 0.12 12.2 0.0 0.42 10.4 0.0 1.9 2 0 0 2 2 2 0 LexA DNA binding domain PLDc_2 PF13091.6 CAV25365.1 - 2e-35 121.6 0.1 1e-17 64.3 0.0 2.2 2 0 0 2 2 2 2 PLD-like domain PLDc PF00614.22 CAV25365.1 - 1.5e-06 28.1 0.8 0.012 15.8 0.1 2.5 2 0 0 2 2 2 2 Phospholipase D Active site motif Nitroreductase PF00881.24 CAV25367.1 - 4.8e-25 88.6 2.2 1.8e-23 83.5 2.2 2.1 1 1 0 1 1 1 1 Nitroreductase family TM1586_NiRdase PF14512.6 CAV25367.1 - 9.5e-05 22.1 0.0 0.23 11.0 0.1 2.1 2 0 0 2 2 2 2 Putative TM nitroreductase YkyB PF14177.6 CAV25367.1 - 0.032 14.5 0.0 0.054 13.8 0.0 1.4 1 0 0 1 1 1 0 YkyB-like protein Oxidored_FMN PF00724.20 CAV25368.1 - 9.2e-54 183.0 0.0 1.3e-53 182.5 0.0 1.0 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family Dus PF01207.17 CAV25368.1 - 0.015 14.5 0.0 0.16 11.0 0.0 2.3 2 1 0 2 2 2 0 Dihydrouridine synthase (Dus) HTH_1 PF00126.27 CAV25370.1 - 1.3e-13 50.7 0.1 2.7e-13 49.7 0.1 1.6 1 0 0 1 1 1 1 Bacterial regulatory helix-turn-helix protein, lysR family LysR_substrate PF03466.20 CAV25370.1 - 1.2e-08 34.6 0.0 1.6e-08 34.2 0.0 1.1 1 0 0 1 1 1 1 LysR substrate binding domain DUF1214 PF06742.11 CAV25372.1 - 8.2e-11 42.3 0.1 1.7e-10 41.3 0.1 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1214) DUF1254 PF06863.12 CAV25372.1 - 1.4e-06 28.4 0.7 0.00018 21.6 0.1 3.2 2 1 1 3 3 3 1 Protein of unknown function (DUF1254) AlphaC_C PF17480.2 CAV25372.1 - 0.021 14.9 0.4 2.2 8.4 0.1 2.5 2 0 0 2 2 2 0 AlphaC C-terminal DUF5545 PF17699.1 CAV25372.1 - 0.082 12.7 0.0 0.13 12.1 0.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5545) DUF465 PF04325.13 CAV25373.1 - 2.9e-10 40.0 4.8 4.2e-10 39.5 2.9 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF465) BRE1 PF08647.11 CAV25373.1 - 0.091 12.8 1.0 0.14 12.3 1.0 1.5 1 1 0 1 1 1 0 BRE1 E3 ubiquitin ligase DAO PF01266.24 CAV25375.1 - 2.7e-46 158.8 0.1 5.7e-46 157.7 0.0 1.5 2 0 0 2 2 2 1 FAD dependent oxidoreductase DAO_C PF16901.5 CAV25375.1 - 4.1e-10 39.6 0.0 8.8e-10 38.5 0.0 1.5 1 0 0 1 1 1 1 C-terminal domain of alpha-glycerophosphate oxidase DUF4657 PF15552.6 CAV25375.1 - 0.038 13.6 0.0 0.064 12.8 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4657) NAD_binding_8 PF13450.6 CAV25375.1 - 0.041 14.1 1.1 0.19 12.0 0.6 2.4 3 0 0 3 3 3 0 NAD(P)-binding Rossmann-like domain K_oxygenase PF13434.6 CAV25375.1 - 0.042 13.0 0.4 2.4 7.2 0.0 2.1 2 0 0 2 2 2 0 L-lysine 6-monooxygenase (NADPH-requiring) 3HCDH_N PF02737.18 CAV25375.1 - 0.13 12.1 0.1 0.24 11.3 0.1 1.5 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Pyr_redox_2 PF07992.14 CAV25375.1 - 0.2 10.9 0.2 0.46 9.7 0.2 1.7 1 1 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 CAV25375.1 - 0.24 10.5 0.5 1.3 8.0 1.0 1.9 2 0 0 2 2 2 0 Glucose inhibited division protein A FAD_binding_2 PF00890.24 CAV25375.1 - 0.27 10.2 4.8 2.4 7.2 4.8 2.1 1 1 0 1 1 1 0 FAD binding domain DeoRC PF00455.22 CAV25377.1 - 2.3e-49 167.4 0.0 3.5e-49 166.8 0.0 1.3 1 0 0 1 1 1 1 DeoR C terminal sensor domain HTH_DeoR PF08220.12 CAV25377.1 - 1.3e-23 82.5 0.0 2.4e-23 81.6 0.0 1.5 1 0 0 1 1 1 1 DeoR-like helix-turn-helix domain HTH_11 PF08279.12 CAV25377.1 - 7.6e-08 32.2 0.0 1.4e-07 31.3 0.0 1.4 1 0 0 1 1 1 1 HTH domain GntR PF00392.21 CAV25377.1 - 5.9e-05 22.6 0.0 0.00019 21.0 0.0 1.9 2 0 0 2 2 2 1 Bacterial regulatory proteins, gntR family Put_DNA-bind_N PF06971.13 CAV25377.1 - 0.0034 17.4 0.0 0.0079 16.2 0.0 1.6 1 0 0 1 1 1 1 Putative DNA-binding protein N-terminus HTH_Crp_2 PF13545.6 CAV25377.1 - 0.005 16.8 0.0 4.1 7.5 0.0 2.4 2 0 0 2 2 2 2 Crp-like helix-turn-helix domain HTH_Mga PF08280.11 CAV25377.1 - 0.018 15.0 0.0 0.037 14.1 0.0 1.5 1 0 0 1 1 1 0 M protein trans-acting positive regulator (MGA) HTH domain Fe_dep_repress PF01325.19 CAV25377.1 - 0.035 14.3 0.0 0.083 13.1 0.0 1.6 1 0 0 1 1 1 0 Iron dependent repressor, N-terminal DNA binding domain HTH_23 PF13384.6 CAV25377.1 - 0.039 13.8 0.0 0.52 10.2 0.0 2.4 2 0 0 2 2 2 0 Homeodomain-like domain TFIIE_alpha PF02002.17 CAV25377.1 - 0.067 13.1 0.0 0.27 11.1 0.0 1.9 2 0 0 2 2 2 0 TFIIE alpha subunit HTH_24 PF13412.6 CAV25377.1 - 0.074 12.6 0.2 0.22 11.1 0.0 1.9 2 0 0 2 2 2 0 Winged helix-turn-helix DNA-binding KapB PF08810.10 CAV25377.1 - 0.079 13.1 0.0 0.3 11.2 0.0 1.9 2 0 0 2 2 2 0 Kinase associated protein B MarR PF01047.22 CAV25377.1 - 0.079 12.9 0.0 0.16 11.9 0.0 1.4 1 0 0 1 1 1 0 MarR family DDRGK PF09756.9 CAV25377.1 - 0.088 12.4 0.1 0.13 11.8 0.1 1.2 1 0 0 1 1 1 0 DDRGK domain HTH_28 PF13518.6 CAV25377.1 - 0.09 12.9 0.0 0.45 10.7 0.0 2.0 2 0 0 2 2 2 0 Helix-turn-helix domain DUF977 PF06163.11 CAV25377.1 - 0.13 12.2 0.0 0.25 11.3 0.0 1.4 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF977) FeoC PF09012.10 CAV25377.1 - 0.23 11.5 0.0 0.43 10.7 0.0 1.4 1 0 0 1 1 1 0 FeoC like transcriptional regulator FGGY_N PF00370.21 CAV25379.1 - 3.7e-85 285.4 0.2 5.1e-85 284.9 0.2 1.2 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain FGGY_C PF02782.16 CAV25379.1 - 1.2e-60 204.7 0.7 3e-59 200.1 0.9 2.2 2 0 0 2 2 2 1 FGGY family of carbohydrate kinases, C-terminal domain MIP PF00230.20 CAV25380.1 - 4.6e-64 216.2 12.9 5.6e-64 216.0 12.9 1.0 1 0 0 1 1 1 1 Major intrinsic protein TauE PF01925.19 CAV25380.1 - 0.18 11.4 28.0 4.9 6.7 7.2 3.2 1 1 1 2 2 2 0 Sulfite exporter TauE/SafE DUF4271 PF14093.6 CAV25380.1 - 0.24 11.3 10.0 0.12 12.3 7.3 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4271) BTP PF05232.12 CAV25382.1 - 1.1e-42 144.0 12.4 1.7e-21 76.1 3.0 2.0 2 0 0 2 2 2 2 Chlorhexidine efflux transporter DUF1129 PF06570.11 CAV25382.1 - 0.0025 17.3 6.5 0.003 17.1 6.5 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1129) DUF962 PF06127.11 CAV25382.1 - 0.11 12.6 1.7 2.8 8.1 1.7 2.2 1 1 0 1 1 1 0 Protein of unknown function (DUF962) PhoR PF11808.8 CAV25382.1 - 0.12 12.8 0.3 0.12 12.8 0.3 2.5 2 1 1 3 3 3 0 Phosphate regulon sensor protein PhoR DUF5134 PF17197.4 CAV25382.1 - 0.25 11.2 7.7 0.44 10.4 7.7 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF5134) OppC_N PF12911.7 CAV25382.1 - 0.32 11.0 4.3 26 4.9 0.6 3.2 3 0 0 3 3 3 0 N-terminal TM domain of oligopeptide transport permease C RseC_MucC PF04246.12 CAV25382.1 - 4.4 7.3 6.4 1.1 9.2 0.2 2.0 2 0 0 2 2 2 0 Positive regulator of sigma(E), RseC/MucC LysR_substrate PF03466.20 CAV25384.1 - 1.6e-17 63.6 0.0 2.8e-17 62.8 0.0 1.4 1 1 0 1 1 1 1 LysR substrate binding domain HTH_1 PF00126.27 CAV25384.1 - 8.8e-15 54.4 0.0 2e-14 53.3 0.0 1.7 1 0 0 1 1 1 1 Bacterial regulatory helix-turn-helix protein, lysR family YniB PF14002.6 CAV25384.1 - 0.12 12.1 0.0 0.2 11.4 0.0 1.3 1 0 0 1 1 1 0 YniB-like protein SBF PF01758.16 CAV25386.1 - 1.5e-58 197.7 16.5 1.5e-58 197.7 16.5 1.8 2 0 0 2 2 2 1 Sodium Bile acid symporter family HTH_5 PF01022.20 CAV25388.1 - 8.8e-12 44.7 0.2 1.4e-11 44.1 0.2 1.3 1 0 0 1 1 1 1 Bacterial regulatory protein, arsR family HTH_20 PF12840.7 CAV25388.1 - 4e-10 39.6 0.2 6e-10 39.0 0.2 1.2 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_24 PF13412.6 CAV25388.1 - 1.5e-07 30.8 0.4 2.9e-07 30.0 0.1 1.5 2 0 0 2 2 2 1 Winged helix-turn-helix DNA-binding MarR PF01047.22 CAV25388.1 - 1.1e-06 28.4 0.1 2e-06 27.6 0.1 1.4 1 0 0 1 1 1 1 MarR family HTH_IclR PF09339.10 CAV25388.1 - 9e-05 22.2 0.5 0.00014 21.6 0.1 1.4 2 0 0 2 2 2 1 IclR helix-turn-helix domain MarR_2 PF12802.7 CAV25388.1 - 0.00053 19.8 0.0 0.00091 19.1 0.0 1.3 1 1 0 1 1 1 1 MarR family TrmB PF01978.19 CAV25388.1 - 0.0028 17.5 0.0 0.0046 16.8 0.0 1.4 1 1 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB HTH_34 PF13601.6 CAV25388.1 - 0.0077 16.4 0.0 0.012 15.8 0.0 1.4 1 0 0 1 1 1 1 Winged helix DNA-binding domain DUF5343 PF17278.2 CAV25388.1 - 0.0087 16.1 0.0 0.01 15.9 0.0 1.2 1 0 0 1 1 1 1 Family of unknown function (DUF5343) Fe_dep_repress PF01325.19 CAV25388.1 - 0.012 15.8 0.0 0.02 15.1 0.0 1.3 1 0 0 1 1 1 0 Iron dependent repressor, N-terminal DNA binding domain HTH_10 PF04967.12 CAV25388.1 - 0.016 15.0 0.1 0.14 12.0 0.0 2.1 2 0 0 2 2 2 0 HTH DNA binding domain RP-C PF03428.13 CAV25388.1 - 0.022 14.4 0.0 0.036 13.7 0.0 1.4 1 0 0 1 1 1 0 Replication protein C N-terminal domain B-block_TFIIIC PF04182.12 CAV25388.1 - 0.03 14.5 0.0 0.04 14.1 0.0 1.2 1 0 0 1 1 1 0 B-block binding subunit of TFIIIC Hydrolase_3 PF08282.12 CAV25390.1 - 4.7e-59 200.2 0.6 5.3e-59 200.0 0.6 1.0 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase S6PP PF05116.13 CAV25390.1 - 4.4e-16 59.2 0.0 2.5e-11 43.6 0.0 2.3 2 0 0 2 2 2 2 Sucrose-6F-phosphate phosphohydrolase Hydrolase PF00702.26 CAV25390.1 - 3.2e-05 24.3 0.1 4.8e-05 23.7 0.1 1.3 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 CAV25390.1 - 0.017 15.6 0.1 1.1 9.6 0.1 2.4 1 1 0 1 1 1 0 haloacid dehalogenase-like hydrolase DSBA PF01323.20 CAV25392.1 - 9e-31 107.1 0.3 1e-30 107.0 0.3 1.0 1 0 0 1 1 1 1 DSBA-like thioredoxin domain Thioredoxin_4 PF13462.6 CAV25392.1 - 1.2e-07 32.1 0.1 2.4e-06 27.8 0.2 2.1 2 0 0 2 2 2 1 Thioredoxin Thioredoxin_3 PF13192.6 CAV25392.1 - 0.00064 19.7 0.0 0.14 12.3 0.0 2.4 2 0 0 2 2 2 2 Thioredoxin domain Thioredoxin_2 PF13098.6 CAV25392.1 - 0.03 14.8 0.1 0.14 12.6 0.0 2.0 2 0 0 2 2 2 0 Thioredoxin-like domain DUF1525 PF07511.11 CAV25392.1 - 0.055 13.6 0.1 0.14 12.3 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1525) HTH_42 PF06224.12 CAV25394.1 - 7.1e-78 262.4 0.0 8.2e-78 262.2 0.0 1.0 1 0 0 1 1 1 1 Winged helix DNA-binding domain Methyltransf_21 PF05050.12 CAV25394.1 - 0.0088 16.1 0.0 0.017 15.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase FkbM domain MCM6_C PF18263.1 CAV25394.1 - 0.0091 16.2 0.0 0.08 13.2 0.1 2.2 2 0 0 2 2 2 1 MCM6 C-terminal winged-helix domain LysR_substrate PF03466.20 CAV25395.1 - 1.3e-37 129.2 0.0 1.1e-36 126.2 0.0 1.9 1 1 0 1 1 1 1 LysR substrate binding domain HTH_1 PF00126.27 CAV25395.1 - 6e-15 54.9 0.1 1.5e-14 53.6 0.1 1.7 1 0 0 1 1 1 1 Bacterial regulatory helix-turn-helix protein, lysR family Med28 PF11594.8 CAV25395.1 - 0.066 13.3 0.1 0.12 12.4 0.1 1.4 1 0 0 1 1 1 0 Mediator complex subunit 28 HTH_45 PF14947.6 CAV25395.1 - 0.089 12.8 0.0 0.18 11.8 0.0 1.5 1 0 0 1 1 1 0 Winged helix-turn-helix DUF5547 PF17701.1 CAV25395.1 - 0.14 12.0 0.1 0.25 11.2 0.1 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5547) ABM PF03992.16 CAV25397.1 - 2.8e-09 36.9 0.1 4.1e-09 36.4 0.1 1.3 1 0 0 1 1 1 1 Antibiotic biosynthesis monooxygenase CbiG_C PF01890.16 CAV25397.1 - 0.03 14.9 0.1 0.045 14.3 0.1 1.4 1 1 0 1 1 1 0 Cobalamin synthesis G C-terminus GFO_IDH_MocA PF01408.22 CAV25398.1 - 1.4e-16 61.4 0.1 2.7e-16 60.4 0.1 1.5 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold NAD_binding_3 PF03447.16 CAV25398.1 - 0.00054 20.6 0.0 0.0013 19.3 0.0 1.6 1 0 0 1 1 1 1 Homoserine dehydrogenase, NAD binding domain Semialdhyde_dh PF01118.24 CAV25398.1 - 0.0064 16.9 0.1 0.012 16.1 0.1 1.5 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain F420_oxidored PF03807.17 CAV25398.1 - 0.012 16.1 0.1 0.029 14.9 0.0 1.7 1 1 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent HemolysinCabind PF00353.19 CAV25402.1 - 0.046 13.7 3.8 0.15 12.1 3.8 1.9 1 0 0 1 1 1 0 RTX calcium-binding nonapeptide repeat (4 copies) DUF5370 PF17340.2 CAV25404.1 - 0.13 12.1 0.5 0.35 10.8 0.5 1.7 1 0 0 1 1 1 0 Family of unknown function (DUF5370) HAD_2 PF13419.6 CAV25406.1 - 5.4e-29 101.5 0.1 6.2e-29 101.3 0.1 1.0 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 CAV25406.1 - 3.6e-12 47.0 0.2 2.9e-10 40.8 0.2 2.1 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 CAV25406.1 - 0.0016 18.4 0.0 0.0048 16.9 0.0 1.7 2 0 0 2 2 2 1 HAD-hyrolase-like HAD PF12710.7 CAV25406.1 - 0.028 14.8 0.0 0.035 14.5 0.0 1.3 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase Acid_PPase PF12689.7 CAV25406.1 - 0.045 13.6 1.0 7.6 6.3 1.0 3.5 1 1 0 1 1 1 0 Acid Phosphatase Ribul_P_3_epim PF00834.19 CAV25407.1 - 1.4e-14 54.0 0.1 1.7e-14 53.7 0.1 1.1 1 0 0 1 1 1 1 Ribulose-phosphate 3 epimerase family QRPTase_C PF01729.19 CAV25407.1 - 3.5e-05 23.7 0.0 4e-05 23.5 0.0 1.1 1 0 0 1 1 1 1 Quinolinate phosphoribosyl transferase, C-terminal domain His_biosynth PF00977.21 CAV25407.1 - 0.00029 20.4 0.1 0.00031 20.3 0.1 1.0 1 0 0 1 1 1 1 Histidine biosynthesis protein YmdB PF13277.6 CAV25407.1 - 0.0068 15.8 0.0 0.0068 15.8 0.0 1.1 1 0 0 1 1 1 1 YmdB-like protein OMPdecase PF00215.24 CAV25407.1 - 0.017 14.7 0.1 0.017 14.7 0.1 1.1 1 0 0 1 1 1 0 Orotidine 5'-phosphate decarboxylase / HUMPS family TMP-TENI PF02581.17 CAV25407.1 - 0.042 13.2 0.0 0.049 13.0 0.0 1.1 1 0 0 1 1 1 0 Thiamine monophosphate synthase MFS_1 PF07690.16 CAV25413.1 - 4.5e-19 68.6 39.9 4.5e-19 68.6 39.9 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily DNA_pol3_alpha PF07733.12 CAV25415.1 - 0.027 14.0 0.3 0.03 13.9 0.3 1.1 1 0 0 1 1 1 0 Bacterial DNA polymerase III alpha NTPase domain LTXXQ PF07813.12 CAV25415.1 - 0.049 14.3 2.7 0.17 12.7 2.7 1.7 1 1 0 1 1 1 0 LTXXQ motif family protein AP_endonuc_2 PF01261.24 CAV25416.1 - 4.4e-34 117.8 0.0 1.4e-33 116.2 0.0 1.6 2 0 0 2 2 2 1 Xylose isomerase-like TIM barrel AP_endonuc_2_N PF07582.12 CAV25416.1 - 0.03 14.0 0.0 0.1 12.4 0.0 1.9 2 0 0 2 2 2 0 AP endonuclease family 2 C terminus NAGidase PF07555.13 CAV25416.1 - 0.094 12.0 0.0 0.13 11.6 0.0 1.2 1 0 0 1 1 1 0 beta-N-acetylglucosaminidase IclR PF01614.18 CAV25418.1 - 1.1e-33 115.9 0.0 8.5e-33 112.9 0.0 2.0 2 0 0 2 2 2 1 Bacterial transcriptional regulator HTH_IclR PF09339.10 CAV25418.1 - 2.3e-13 49.7 0.0 6.3e-13 48.3 0.0 1.8 1 0 0 1 1 1 1 IclR helix-turn-helix domain MarR_2 PF12802.7 CAV25418.1 - 2.6e-05 24.0 0.0 0.00013 21.7 0.0 2.0 2 0 0 2 2 2 1 MarR family Rrf2 PF02082.20 CAV25418.1 - 0.051 13.9 0.0 0.14 12.5 0.0 1.7 1 0 0 1 1 1 0 Transcriptional regulator HTH_24 PF13412.6 CAV25418.1 - 0.094 12.3 0.0 0.19 11.3 0.0 1.5 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding OMPdecase PF00215.24 CAV25420.1 - 4.4e-23 82.1 1.5 5.5e-23 81.7 1.5 1.0 1 0 0 1 1 1 1 Orotidine 5'-phosphate decarboxylase / HUMPS family QRPTase_C PF01729.19 CAV25420.1 - 0.062 13.1 0.3 9.6 6.0 0.1 2.4 2 1 0 2 2 2 0 Quinolinate phosphoribosyl transferase, C-terminal domain FGGY_N PF00370.21 CAV25422.1 - 2.1e-72 243.7 0.0 2.7e-72 243.3 0.0 1.2 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain FGGY_C PF02782.16 CAV25422.1 - 7.7e-25 87.8 0.1 1.3e-24 87.1 0.1 1.4 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain BcrAD_BadFG PF01869.20 CAV25422.1 - 0.00014 21.4 0.1 0.00034 20.2 0.1 1.6 2 0 0 2 2 2 1 BadF/BadG/BcrA/BcrD ATPase family DUF386 PF04074.12 CAV25423.1 - 1.4e-32 112.7 0.1 1.5e-32 112.5 0.1 1.0 1 0 0 1 1 1 1 YhcH/YjgK/YiaL Hydrolase_3 PF08282.12 CAV25424.1 - 8.1e-63 212.5 0.4 9.3e-63 212.3 0.4 1.0 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase S6PP PF05116.13 CAV25424.1 - 3.3e-16 59.6 0.2 2.6e-07 30.4 0.0 2.1 2 0 0 2 2 2 2 Sucrose-6F-phosphate phosphohydrolase Hydrolase PF00702.26 CAV25424.1 - 8.2e-10 39.3 0.2 2.6e-07 31.2 0.2 2.9 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 CAV25424.1 - 1.5e-08 35.3 0.2 0.0015 19.0 0.0 2.9 2 1 1 3 3 3 2 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 CAV25424.1 - 0.00012 22.2 0.1 0.055 13.6 0.0 2.6 2 1 1 3 3 3 2 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 CAV25424.1 - 0.033 14.2 0.0 0.068 13.3 0.0 1.5 1 0 0 1 1 1 0 HAD-hyrolase-like DNA_pol_A_exo1 PF01612.20 CAV25424.1 - 0.034 13.9 1.4 3 7.5 0.0 2.4 2 1 0 2 2 2 0 3'-5' exonuclease sCache_3_2 PF17203.4 CAV25424.1 - 0.09 12.9 0.1 0.17 12.0 0.1 1.4 1 0 0 1 1 1 0 Single cache domain 3 Aldolase_II PF00596.21 CAV25426.1 - 3e-42 144.7 0.0 3.5e-42 144.4 0.0 1.1 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain Glyco_transf_4 PF13439.6 CAV25426.1 - 0.11 12.5 0.0 0.2 11.6 0.0 1.4 1 0 0 1 1 1 0 Glycosyltransferase Family 4 DctP PF03480.13 CAV25428.1 - 1.2e-90 303.7 0.9 1.4e-90 303.5 0.9 1.0 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein, family 7 PepSY_2 PF13670.6 CAV25428.1 - 0.12 12.4 1.0 16 5.6 0.1 2.4 2 0 0 2 2 2 0 Peptidase propeptide and YPEB domain DctM PF06808.12 CAV25430.1 - 1.3e-113 379.9 53.6 1.6e-113 379.7 53.6 1.0 1 0 0 1 1 1 1 Tripartite ATP-independent periplasmic transporter, DctM component CitMHS PF03600.16 CAV25430.1 - 0.00028 20.2 67.7 0.015 14.6 38.6 2.5 1 1 1 2 2 2 2 Citrate transporter DctQ PF04290.12 CAV25432.1 - 1.3e-25 89.9 8.4 1.8e-25 89.4 8.4 1.2 1 0 0 1 1 1 1 Tripartite ATP-independent periplasmic transporters, DctQ component Voltage_CLC PF00654.20 CAV25432.1 - 0.31 10.2 7.8 0.57 9.4 7.8 1.4 1 1 0 1 1 1 0 Voltage gated chloride channel DUF872 PF05915.12 CAV25432.1 - 1.2 9.3 7.7 1.2 9.3 0.7 2.2 1 1 0 2 2 2 0 Eukaryotic protein of unknown function (DUF872) DUF2975 PF11188.8 CAV25432.1 - 4.3 7.2 11.6 0.48 10.3 1.3 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2975) Ldh_2 PF02615.14 CAV25433.1 - 3.8e-89 299.1 0.1 4.2e-89 299.0 0.1 1.0 1 0 0 1 1 1 1 Malate/L-lactate dehydrogenase Gly_kinase PF02595.15 CAV25435.1 - 9.7e-137 455.8 6.3 1.1e-136 455.7 6.3 1.0 1 0 0 1 1 1 1 Glycerate kinase family Catalase PF00199.19 CAV25437.1 - 1.1e-189 630.5 0.8 1.3e-189 630.2 0.8 1.0 1 0 0 1 1 1 1 Catalase Catalase-rel PF06628.12 CAV25437.1 - 3e-21 75.4 0.0 6e-21 74.4 0.0 1.5 1 0 0 1 1 1 1 Catalase-related immune-responsive Patatin PF01734.22 CAV25439.1 - 1.1e-12 48.6 0.6 1.6e-10 41.5 0.6 2.2 1 1 0 1 1 1 1 Patatin-like phospholipase 2-Hacid_dh_C PF02826.19 CAV25440.1 - 1.2e-51 174.6 0.0 1.8e-51 174.0 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 CAV25440.1 - 4e-31 107.4 0.0 4.5e-31 107.3 0.0 1.0 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.15 CAV25440.1 - 0.00034 20.8 0.1 0.0013 18.9 0.0 1.9 2 1 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase IlvN PF07991.12 CAV25440.1 - 0.00037 20.1 0.0 0.0012 18.5 0.0 1.8 2 0 0 2 2 2 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain XdhC_C PF13478.6 CAV25440.1 - 0.0055 17.2 0.0 0.015 15.8 0.0 1.7 2 0 0 2 2 2 1 XdhC Rossmann domain ADH_zinc_N PF00107.26 CAV25440.1 - 0.0097 15.9 0.0 0.5 10.4 0.0 2.5 2 1 0 2 2 2 1 Zinc-binding dehydrogenase AdoHcyase_NAD PF00670.21 CAV25440.1 - 0.011 15.8 0.0 0.025 14.7 0.0 1.6 1 1 0 1 1 1 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain Glu_dehyd_C PF16912.5 CAV25440.1 - 0.012 15.1 0.0 0.026 14.0 0.0 1.6 1 0 0 1 1 1 0 Glucose dehydrogenase C-terminus Oxidored_nitro PF00148.19 CAV25440.1 - 0.037 12.8 0.0 0.15 10.8 0.0 1.9 1 1 1 2 2 2 0 Nitrogenase component 1 type Oxidoreductase AlaDh_PNT_C PF01262.21 CAV25440.1 - 0.038 13.3 0.0 0.09 12.1 0.0 1.7 1 1 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain UDPG_MGDP_dh_N PF03721.14 CAV25440.1 - 0.06 12.9 0.0 0.13 11.8 0.0 1.6 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain DUF1971 PF09313.11 CAV25442.1 - 4.9e-27 93.7 0.0 6.6e-27 93.4 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF1971) Cupin_8 PF13621.6 CAV25442.1 - 0.051 13.3 0.0 0.078 12.7 0.0 1.3 1 1 0 1 1 1 0 Cupin-like domain Cupin_2 PF07883.11 CAV25442.1 - 0.085 12.6 0.0 0.13 12.0 0.0 1.4 1 1 0 1 1 1 0 Cupin domain NAD_binding_1 PF00175.21 CAV25444.1 - 1.1e-15 58.2 0.0 1.7e-15 57.6 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.24 CAV25444.1 - 1.3e-07 31.8 0.0 2.6e-07 30.9 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_6 PF08030.12 CAV25444.1 - 0.072 13.2 0.0 1.7 8.7 0.0 2.1 1 1 1 2 2 2 0 Ferric reductase NAD binding domain Acyltransferase PF01553.21 CAV25446.1 - 8.2e-16 57.9 0.0 1.1e-15 57.4 0.0 1.2 1 0 0 1 1 1 1 Acyltransferase Acyltransf_C PF16076.5 CAV25446.1 - 0.18 11.9 4.3 0.12 12.5 0.8 2.5 3 1 0 3 3 3 0 Acyltransferase C-terminus Polysacc_deac_2 PF04748.13 CAV25448.1 - 0.14 11.3 0.0 0.19 10.9 0.0 1.1 1 0 0 1 1 1 0 Divergent polysaccharide deacetylase Methyltransf_18 PF12847.7 CAV25449.1 - 1.3e-26 93.3 0.0 2.7e-26 92.3 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain TrmK PF04816.12 CAV25449.1 - 7.3e-13 48.5 0.9 4.2e-12 46.0 0.9 2.0 1 1 0 1 1 1 1 tRNA (adenine(22)-N(1))-methyltransferase PXA PF02194.15 CAV25449.1 - 0.045 13.7 0.0 0.087 12.8 0.0 1.7 1 1 0 1 1 1 0 PXA domain MTS PF05175.14 CAV25449.1 - 0.091 12.3 0.0 0.21 11.1 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase small domain GGDEF PF00990.21 CAV25452.1 - 1.4e-17 63.9 0.1 2.7e-17 63.0 0.1 1.4 1 0 0 1 1 1 1 Diguanylate cyclase, GGDEF domain dCache_1 PF02743.18 CAV25452.1 - 4.7e-08 33.1 3.3 7.4e-08 32.5 2.7 1.7 2 0 0 2 2 2 1 Cache domain Cache_3-Cache_2 PF17201.4 CAV25452.1 - 1.9e-05 24.1 0.0 4.2e-05 23.0 0.0 1.5 1 0 0 1 1 1 1 Cache 3/Cache 2 fusion domain sCache_3_2 PF17203.4 CAV25452.1 - 0.0081 16.3 0.0 0.024 14.8 0.0 1.8 1 0 0 1 1 1 1 Single cache domain 3 Alpha-amylase PF00128.24 CAV25454.1 - 4.2e-09 36.4 0.2 3.1e-05 23.7 0.0 2.6 1 1 1 2 2 2 2 Alpha amylase, catalytic domain CBM_48 PF02922.18 CAV25454.1 - 1.8e-08 34.6 0.0 4.8e-08 33.3 0.0 1.8 1 0 0 1 1 1 1 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) APT PF03440.14 CAV25454.1 - 0.062 13.3 0.0 0.33 10.9 0.0 2.2 2 0 0 2 2 2 0 Aerolysin/Pertussis toxin (APT) domain LamB PF02264.15 CAV25457.1 - 8.5e-38 131.2 10.2 1e-37 131.0 10.2 1.0 1 0 0 1 1 1 1 LamB porin MalM PF07148.12 CAV25459.1 - 5.4e-43 146.0 0.0 9.9e-43 145.1 0.0 1.4 1 0 0 1 1 1 1 Maltose operon periplasmic protein precursor (MalM) Esterase PF00756.20 CAV25462.1 - 4.8e-25 88.6 0.0 6.5e-25 88.2 0.0 1.2 1 0 0 1 1 1 1 Putative esterase Hydrolase_4 PF12146.8 CAV25462.1 - 0.00094 18.5 0.0 0.0024 17.2 0.0 1.6 1 1 1 2 2 2 1 Serine aminopeptidase, S33 GDE_C PF06202.14 CAV25464.1 - 9.8e-97 324.3 4.0 1.5e-96 323.7 4.0 1.2 1 0 0 1 1 1 1 Amylo-alpha-1,6-glucosidase Bac_rhamnosid6H PF17389.2 CAV25464.1 - 5.7e-06 25.8 0.2 5.7e-06 25.8 0.2 1.6 2 0 0 2 2 2 1 Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain DUF608 PF04685.13 CAV25464.1 - 0.014 14.6 0.1 0.026 13.7 0.1 1.4 1 0 0 1 1 1 0 Glycosyl-hydrolase family 116, catalytic region SBP_bac_8 PF13416.6 CAV25466.1 - 2.6e-45 155.4 7.6 3.5e-45 155.0 7.6 1.2 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_1 PF01547.25 CAV25466.1 - 2.1e-38 133.0 12.7 3e-38 132.5 12.7 1.1 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_11 PF13531.6 CAV25466.1 - 0.0021 17.8 0.0 0.0054 16.5 0.0 1.7 1 1 0 1 1 1 1 Bacterial extracellular solute-binding protein Imm70 PF15601.6 CAV25466.1 - 0.095 12.3 0.1 0.2 11.2 0.1 1.5 1 0 0 1 1 1 0 Immunity protein 70 Alpha-amylase PF00128.24 CAV25468.1 - 2.3e-122 408.8 3.5 3.5e-122 408.2 3.5 1.2 1 0 0 1 1 1 1 Alpha amylase, catalytic domain Malt_amylase_C PF16657.5 CAV25468.1 - 1.3e-10 41.3 0.1 2.7e-10 40.2 0.1 1.5 1 0 0 1 1 1 1 Maltogenic Amylase, C-terminal domain hDGE_amylase PF14701.6 CAV25468.1 - 1.9e-05 24.0 0.0 4e-05 22.9 0.0 1.5 1 0 0 1 1 1 1 Glycogen debranching enzyme, glucanotransferase domain Alpha-amylase_C PF02806.18 CAV25468.1 - 0.00029 21.2 0.0 0.0008 19.8 0.0 1.7 1 0 0 1 1 1 1 Alpha amylase, C-terminal all-beta domain DUF3459 PF11941.8 CAV25468.1 - 0.00054 20.2 0.0 0.0015 18.8 0.0 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF3459) Cyc-maltodext_C PF10438.9 CAV25468.1 - 0.039 14.0 0.0 0.11 12.5 0.0 1.8 1 0 0 1 1 1 0 Cyclo-malto-dextrinase C-terminal domain Slu7 PF11708.8 CAV25468.1 - 0.056 13.2 0.4 0.15 11.8 0.3 1.7 2 0 0 2 2 2 0 Pre-mRNA splicing Prp18-interacting factor HTH_1 PF00126.27 CAV25469.1 - 5.5e-19 67.9 0.0 1.3e-18 66.7 0.0 1.6 1 0 0 1 1 1 1 Bacterial regulatory helix-turn-helix protein, lysR family LysR_substrate PF03466.20 CAV25469.1 - 8.7e-11 41.6 0.0 1.4e-10 40.9 0.0 1.3 1 0 0 1 1 1 1 LysR substrate binding domain HTH_24 PF13412.6 CAV25469.1 - 0.03 13.9 0.0 0.052 13.1 0.0 1.4 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding DUF3500 PF12006.8 CAV25469.1 - 0.069 12.6 0.2 0.1 12.1 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3500) MarR PF01047.22 CAV25469.1 - 0.086 12.8 0.0 0.15 12.0 0.0 1.4 1 0 0 1 1 1 0 MarR family HTH_28 PF13518.6 CAV25469.1 - 0.095 12.8 0.0 0.23 11.6 0.0 1.7 1 0 0 1 1 1 0 Helix-turn-helix domain DUF1593 PF07632.11 CAV25471.1 - 0.086 12.3 0.1 0.088 12.2 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1593) NACHT PF05729.12 CAV25473.1 - 1.5e-07 31.5 0.6 1.3e-06 28.5 0.0 2.8 3 0 0 3 3 3 1 NACHT domain Mrr_cat_2 PF13156.6 CAV25473.1 - 2.2e-05 24.4 1.3 7.2e-05 22.7 0.1 2.3 2 0 0 2 2 2 1 Restriction endonuclease AAA_22 PF13401.6 CAV25473.1 - 0.00022 21.5 0.0 0.0011 19.2 0.0 2.3 2 0 0 2 2 2 1 AAA domain IstB_IS21 PF01695.17 CAV25473.1 - 0.002 17.9 0.0 0.0078 16.0 0.0 2.0 1 0 0 1 1 1 1 IstB-like ATP binding protein NLRC4_HD2 PF17776.1 CAV25473.1 - 0.0023 18.5 4.6 0.51 10.9 0.1 4.4 4 0 0 4 4 4 1 NLRC4 helical domain HD2 FtsK_SpoIIIE PF01580.18 CAV25473.1 - 0.046 13.1 0.0 0.09 12.1 0.0 1.4 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_19 PF13245.6 CAV25473.1 - 0.089 13.1 0.0 0.28 11.5 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.6 CAV25473.1 - 0.11 12.2 0.2 0.44 10.3 0.2 2.0 1 0 0 1 1 1 0 P-loop containing region of AAA domain SMC_N PF02463.19 CAV25473.1 - 0.12 11.8 0.1 0.3 10.5 0.1 1.6 1 0 0 1 1 1 0 RecF/RecN/SMC N terminal domain ABC_tran PF00005.27 CAV25473.1 - 0.13 12.8 0.0 0.43 11.1 0.0 1.9 1 0 0 1 1 1 0 ABC transporter AAA_16 PF13191.6 CAV25473.1 - 0.74 10.2 2.3 22 5.4 2.3 2.6 1 1 0 1 1 1 0 AAA ATPase domain UvrD-helicase PF00580.21 CAV25473.1 - 0.78 9.2 5.3 0.24 10.9 0.1 2.7 2 1 1 3 3 3 0 UvrD/REP helicase N-terminal domain AAA_23 PF13476.6 CAV25473.1 - 5.2 7.5 7.7 8.7 6.8 0.0 3.8 4 0 0 4 4 3 0 AAA domain Alpha-amylase PF00128.24 CAV25475.1 - 9.1e-25 87.9 4.0 1e-13 51.6 0.2 2.7 3 0 0 3 3 3 2 Alpha amylase, catalytic domain hDGE_amylase PF14701.6 CAV25475.1 - 4.6e-06 26.0 0.2 1.7e-05 24.1 0.0 1.9 2 0 0 2 2 2 1 Glycogen debranching enzyme, glucanotransferase domain Alpha-amylase_C PF02806.18 CAV25475.1 - 0.04 14.4 0.0 0.11 13.0 0.0 1.8 1 0 0 1 1 1 0 Alpha amylase, C-terminal all-beta domain Malt_amylase_C PF16657.5 CAV25475.1 - 0.12 12.5 0.0 0.27 11.4 0.0 1.6 1 0 0 1 1 1 0 Maltogenic Amylase, C-terminal domain DUF3372 PF11852.8 CAV25476.1 - 5e-63 211.5 0.2 1e-62 210.5 0.2 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3372) Pullulanase_N2 PF17967.1 CAV25476.1 - 1.2e-28 100.2 0.1 6.1e-28 97.9 0.1 2.3 1 0 0 1 1 1 1 Pullulanase N2 domain PUD PF03714.14 CAV25476.1 - 9.1e-19 68.1 1.0 2.6e-18 66.6 0.2 2.3 2 0 0 2 2 2 1 Bacterial pullanase-associated domain CBM_48 PF02922.18 CAV25476.1 - 2.1e-15 56.8 0.1 1.3e-14 54.3 0.0 2.4 2 0 0 2 2 2 1 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) Alpha-amylase PF00128.24 CAV25476.1 - 3.7e-08 33.3 0.5 0.00057 19.5 0.0 3.4 3 0 0 3 3 3 2 Alpha amylase, catalytic domain SusF_SusE PF16411.5 CAV25476.1 - 8.7e-06 26.3 0.4 3.9e-05 24.2 0.1 2.3 2 0 0 2 2 2 1 Outer membrane protein SusF_SusE Pullulanase_Ins PF18494.1 CAV25476.1 - 0.00011 22.6 0.3 0.00033 21.1 0.3 1.9 1 0 0 1 1 1 1 Pullulanase Ins domain Cyc-maltodext_C PF10438.9 CAV25476.1 - 0.018 15.1 0.0 0.065 13.3 0.0 2.0 1 0 0 1 1 1 0 Cyclo-malto-dextrinase C-terminal domain DUF3512 PF12024.8 CAV25476.1 - 0.049 13.1 0.0 0.25 10.8 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF3512) AMPK1_CBM PF16561.5 CAV25476.1 - 0.12 12.6 0.5 0.41 10.9 0.1 2.1 2 0 0 2 2 2 0 Glycogen recognition site of AMP-activated protein kinase DUF1294 PF06961.13 CAV25478.1 - 7.8e-25 86.9 0.1 1.4e-24 86.1 0.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1294) TauE PF01925.19 CAV25478.1 - 0.0033 17.1 3.6 0.0064 16.1 3.6 1.4 1 1 0 1 1 1 1 Sulfite exporter TauE/SafE DUF1097 PF06496.11 CAV25478.1 - 0.0039 17.3 4.7 0.0077 16.3 4.7 1.7 1 1 0 1 1 1 1 Protein of unknown function (DUF1097) PRA1 PF03208.19 CAV25478.1 - 0.14 11.8 4.0 0.75 9.4 1.4 2.0 2 0 0 2 2 2 0 PRA1 family protein DUF2070 PF09843.9 CAV25478.1 - 0.28 9.4 2.9 0.3 9.3 2.9 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) DUF1129 PF06570.11 CAV25478.1 - 3 7.3 6.1 16 4.9 1.7 2.1 1 1 0 2 2 2 0 Protein of unknown function (DUF1129) LysE PF01810.18 CAV25480.1 - 7.8e-14 51.6 14.5 1.1e-13 51.1 14.5 1.1 1 0 0 1 1 1 1 LysE type translocator SirB PF04247.12 CAV25480.1 - 0.017 15.2 3.9 0.049 13.7 3.9 1.9 1 1 0 1 1 1 0 Invasion gene expression up-regulator, SirB DUF4077 PF13295.6 CAV25480.1 - 0.023 14.6 1.7 0.035 14.0 1.5 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4077) Phageshock_PspG PF09583.10 CAV25480.1 - 0.056 13.7 4.7 0.2 12.0 4.7 2.0 1 0 0 1 1 1 0 Phage shock protein G (Phageshock_PspG) AsnC_trans_reg PF01037.21 CAV25482.1 - 1.8e-16 59.8 0.1 2.9e-16 59.2 0.1 1.3 1 0 0 1 1 1 1 Lrp/AsnC ligand binding domain HTH_24 PF13412.6 CAV25482.1 - 2.1e-16 59.2 1.5 3.1e-16 58.7 1.5 1.3 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding HTH_AsnC-type PF13404.6 CAV25482.1 - 9.9e-14 50.9 1.9 1.4e-13 50.4 1.9 1.3 1 0 0 1 1 1 1 AsnC-type helix-turn-helix domain MarR PF01047.22 CAV25482.1 - 6.4e-05 22.8 0.1 0.00012 22.0 0.1 1.4 1 0 0 1 1 1 1 MarR family HTH_Crp_2 PF13545.6 CAV25482.1 - 0.0013 18.7 0.6 0.0036 17.2 0.6 1.7 1 1 0 1 1 1 1 Crp-like helix-turn-helix domain HTH_IclR PF09339.10 CAV25482.1 - 0.0016 18.2 0.0 0.0026 17.5 0.0 1.4 1 0 0 1 1 1 1 IclR helix-turn-helix domain HTH_11 PF08279.12 CAV25482.1 - 0.0025 17.7 0.8 0.0045 16.9 0.5 1.5 2 0 0 2 2 2 1 HTH domain MarR_2 PF12802.7 CAV25482.1 - 0.011 15.6 0.2 0.02 14.8 0.2 1.4 1 0 0 1 1 1 0 MarR family Ribosomal_S25 PF03297.15 CAV25482.1 - 0.046 13.9 0.1 0.43 10.8 0.0 2.3 3 0 0 3 3 3 0 S25 ribosomal protein HTH_DeoR PF08220.12 CAV25482.1 - 0.088 12.6 0.2 0.18 11.6 0.2 1.5 1 0 0 1 1 1 0 DeoR-like helix-turn-helix domain LexA_DNA_bind PF01726.16 CAV25482.1 - 0.11 12.3 0.0 0.23 11.2 0.0 1.5 1 0 0 1 1 1 0 LexA DNA binding domain HTH_39 PF14090.6 CAV25482.1 - 0.13 12.0 0.1 0.33 10.8 0.1 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain LysR_substrate PF03466.20 CAV25484.1 - 7.7e-34 116.9 0.0 1.2e-33 116.3 0.0 1.3 1 0 0 1 1 1 1 LysR substrate binding domain HTH_1 PF00126.27 CAV25484.1 - 4.1e-18 65.1 0.1 6.4e-18 64.5 0.1 1.3 1 0 0 1 1 1 1 Bacterial regulatory helix-turn-helix protein, lysR family Sel1 PF08238.12 CAV25487.1 - 1e-16 61.0 5.3 2.9e-06 27.8 0.0 5.1 5 0 0 5 5 5 3 Sel1 repeat HNF-1_N PF04814.13 CAV25487.1 - 0.0079 16.8 2.7 0.014 16.0 2.7 1.3 1 0 0 1 1 1 1 Hepatocyte nuclear factor 1 (HNF-1), N terminus DUF4449 PF14613.6 CAV25487.1 - 0.13 12.3 4.2 0.071 13.2 0.7 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF4449) SDF PF00375.18 CAV25489.1 - 1.1e-66 225.4 41.2 1.3e-66 225.3 41.2 1.0 1 0 0 1 1 1 1 Sodium:dicarboxylate symporter family RsgA_GTPase PF03193.16 CAV25493.1 - 4.3e-48 163.4 0.2 6.2e-48 162.9 0.2 1.2 1 0 0 1 1 1 1 RsgA GTPase MMR_HSR1 PF01926.23 CAV25493.1 - 1.4e-08 34.8 0.0 1.9e-07 31.2 0.0 2.2 2 0 0 2 2 2 1 50S ribosome-binding GTPase ABC_tran PF00005.27 CAV25493.1 - 4.1e-08 33.8 0.4 9.4e-08 32.7 0.4 1.8 1 1 0 1 1 1 1 ABC transporter FeoB_N PF02421.18 CAV25493.1 - 7.9e-05 22.2 1.3 0.023 14.2 0.0 2.3 2 0 0 2 2 2 1 Ferrous iron transport protein B AAA_16 PF13191.6 CAV25493.1 - 0.00025 21.5 0.6 0.00047 20.6 0.3 1.7 1 1 0 1 1 1 1 AAA ATPase domain AIG1 PF04548.16 CAV25493.1 - 0.00042 19.7 0.9 0.0023 17.3 0.0 2.3 2 0 0 2 2 2 1 AIG1 family Dynamin_N PF00350.23 CAV25493.1 - 0.0015 18.6 8.6 0.13 12.3 0.7 3.4 3 1 1 4 4 3 2 Dynamin family AAA_33 PF13671.6 CAV25493.1 - 0.002 18.3 1.4 0.034 14.3 0.3 2.6 2 1 0 2 2 2 1 AAA domain Septin PF00735.18 CAV25493.1 - 0.0027 17.0 0.1 0.0048 16.2 0.1 1.3 1 0 0 1 1 1 1 Septin GTP_EFTU PF00009.27 CAV25493.1 - 0.0042 16.6 4.0 0.38 10.3 0.8 2.3 1 1 1 2 2 2 2 Elongation factor Tu GTP binding domain AAA_7 PF12775.7 CAV25493.1 - 0.0083 15.7 0.1 0.015 14.8 0.1 1.4 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_29 PF13555.6 CAV25493.1 - 0.01 15.5 0.3 0.023 14.4 0.3 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain IstB_IS21 PF01695.17 CAV25493.1 - 0.021 14.5 0.0 0.045 13.5 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_25 PF13481.6 CAV25493.1 - 0.035 13.7 0.0 0.065 12.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain DUF815 PF05673.13 CAV25493.1 - 0.037 13.2 0.2 0.08 12.1 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF815) cobW PF02492.19 CAV25493.1 - 0.043 13.4 2.3 1.1 8.8 0.1 2.3 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain VirE PF05272.11 CAV25493.1 - 0.046 13.5 0.0 0.075 12.8 0.0 1.4 1 0 0 1 1 1 0 Virulence-associated protein E Ras PF00071.22 CAV25493.1 - 0.054 13.1 1.6 2.7 7.6 0.0 2.3 2 0 0 2 2 2 0 Ras family PduV-EutP PF10662.9 CAV25493.1 - 0.077 12.7 1.6 2.2 8.0 0.1 2.5 2 1 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_22 PF13401.6 CAV25493.1 - 0.082 13.2 0.3 0.082 13.2 0.3 2.0 3 0 0 3 3 2 0 AAA domain DUF705 PF05152.12 CAV25493.1 - 0.089 12.2 0.2 0.13 11.7 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF705) NACHT PF05729.12 CAV25493.1 - 0.092 12.7 0.3 0.2 11.6 0.3 1.5 1 0 0 1 1 1 0 NACHT domain MeaB PF03308.16 CAV25493.1 - 0.099 11.6 0.1 0.2 10.6 0.1 1.4 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB RNA_helicase PF00910.22 CAV25493.1 - 0.1 13.0 0.9 0.18 12.2 0.1 1.9 2 0 0 2 2 1 0 RNA helicase AAA_24 PF13479.6 CAV25493.1 - 0.11 12.2 0.1 0.2 11.4 0.1 1.4 1 0 0 1 1 1 0 AAA domain ATP_bind_1 PF03029.17 CAV25493.1 - 0.13 12.0 1.2 9.6 5.9 0.1 2.6 3 0 0 3 3 3 0 Conserved hypothetical ATP binding protein Roc PF08477.13 CAV25493.1 - 0.16 12.2 0.5 0.5 10.6 0.1 2.0 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase DUF87 PF01935.17 CAV25493.1 - 0.17 11.9 1.4 0.42 10.7 1.4 1.6 1 0 0 1 1 1 0 Helicase HerA, central domain AAA_18 PF13238.6 CAV25493.1 - 1 9.9 5.2 1.9 9.0 0.2 3.1 4 1 1 5 5 3 0 AAA domain IBB PF01749.20 CAV25493.1 - 2.5 8.6 5.8 3.1 8.3 1.2 2.3 2 0 0 2 2 2 0 Importin beta binding domain PCuAC PF04314.13 CAV25494.1 - 2.9e-39 133.2 0.4 4.1e-39 132.8 0.4 1.2 1 0 0 1 1 1 1 Copper chaperone PCu(A)C SCO1-SenC PF02630.14 CAV25496.1 - 1.3e-35 122.2 0.1 1.6e-35 121.9 0.1 1.2 1 0 0 1 1 1 1 SCO1/SenC Thioredoxin_8 PF13905.6 CAV25496.1 - 0.009 16.3 0.0 0.029 14.7 0.0 1.8 2 0 0 2 2 2 1 Thioredoxin-like DUF368 PF04018.13 CAV25500.1 - 1e-96 323.3 15.6 1e-96 323.3 15.6 1.3 2 0 0 2 2 2 1 Domain of unknown function (DUF368) TPR_MalT PF17874.1 CAV25502.1 - 1.6e-94 317.0 13.0 1.6e-94 317.0 13.0 2.7 2 1 0 2 2 2 1 MalT-like TPR region GerE PF00196.19 CAV25502.1 - 9.8e-20 69.9 0.0 2e-19 68.9 0.0 1.6 1 0 0 1 1 1 1 Bacterial regulatory proteins, luxR family AAA_16 PF13191.6 CAV25502.1 - 0.00017 22.0 0.7 0.0012 19.3 0.0 2.7 2 1 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 CAV25502.1 - 0.00025 21.3 1.3 0.19 12.0 0.0 3.5 3 0 0 3 3 3 1 AAA domain TPR_1 PF00515.28 CAV25502.1 - 0.0034 17.1 0.2 1.7 8.6 0.0 4.5 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_8 PF13181.6 CAV25502.1 - 0.0043 17.1 2.9 38 4.8 0.0 5.9 7 0 0 7 7 7 0 Tetratricopeptide repeat Sigma70_r4_2 PF08281.12 CAV25502.1 - 0.0084 15.8 0.0 0.024 14.3 0.0 1.8 1 0 0 1 1 1 1 Sigma-70, region 4 Sigma70_r4 PF04545.16 CAV25502.1 - 0.012 15.1 0.0 0.029 13.9 0.0 1.7 1 0 0 1 1 1 0 Sigma-70, region 4 HTH_23 PF13384.6 CAV25502.1 - 0.016 15.0 0.0 0.06 13.2 0.0 2.0 1 0 0 1 1 1 0 Homeodomain-like domain TPR_12 PF13424.6 CAV25502.1 - 0.04 14.2 15.3 2.5 8.4 0.3 5.2 5 1 1 6 6 6 0 Tetratricopeptide repeat HTH_40 PF14493.6 CAV25502.1 - 0.073 13.5 0.1 0.32 11.5 0.1 2.1 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_10 PF04967.12 CAV25502.1 - 0.13 12.1 0.5 0.77 9.6 0.0 2.6 3 0 0 3 3 3 0 HTH DNA binding domain TPR_19 PF14559.6 CAV25502.1 - 0.37 11.3 13.7 1.1 9.8 0.0 5.8 5 2 0 5 5 5 0 Tetratricopeptide repeat Phosphorylase PF00343.20 CAV25504.1 - 0 1028.4 0.0 0 1028.2 0.0 1.0 1 0 0 1 1 1 1 Carbohydrate phosphorylase Glyco_hydro_77 PF02446.17 CAV25506.1 - 5.4e-130 434.4 0.0 6.8e-130 434.0 0.0 1.0 1 0 0 1 1 1 1 4-alpha-glucanotransferase CBM_48 PF02922.18 CAV25508.1 - 7.2e-22 77.5 0.0 7.8e-19 67.8 0.0 2.7 2 0 0 2 2 2 2 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) Alpha-amylase_C PF02806.18 CAV25508.1 - 1.1e-16 61.1 0.0 3.6e-16 59.4 0.0 1.9 1 0 0 1 1 1 1 Alpha amylase, C-terminal all-beta domain Alpha-amylase PF00128.24 CAV25508.1 - 1.9e-10 40.9 0.4 1.1e-06 28.4 0.0 2.5 2 1 0 2 2 2 2 Alpha amylase, catalytic domain CbiQ PF02361.16 CAV25509.1 - 1.3e-30 106.7 9.5 1.3e-30 106.7 9.5 1.6 2 0 0 2 2 2 1 Cobalt transport protein ABC_tran PF00005.27 CAV25511.1 - 4.1e-57 192.5 1.6 5.5e-29 101.4 0.0 2.5 3 0 0 3 3 2 2 ABC transporter DUF3744 PF12558.8 CAV25511.1 - 7.6e-21 74.7 0.1 1.6e-20 73.6 0.1 1.6 1 0 0 1 1 1 1 ATP-binding cassette cobalt transporter AAA_21 PF13304.6 CAV25511.1 - 1.8e-17 64.1 9.1 0.0009 19.1 0.0 4.2 3 1 1 4 4 4 4 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 CAV25511.1 - 1.3e-11 44.4 6.9 6.6e-06 25.7 0.2 3.1 2 1 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 CAV25511.1 - 2.7e-08 33.4 2.2 0.0026 17.5 0.1 2.4 2 0 0 2 2 2 2 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 CAV25511.1 - 5.5e-07 29.6 0.6 0.0051 16.7 0.1 2.8 2 0 0 2 2 2 2 RsgA GTPase AAA_23 PF13476.6 CAV25511.1 - 1.6e-06 28.8 1.0 0.046 14.2 0.1 2.4 2 0 0 2 2 2 2 AAA domain AAA_24 PF13479.6 CAV25511.1 - 3.9e-06 26.7 0.2 0.043 13.5 0.0 2.8 3 0 0 3 3 2 2 AAA domain Mg_chelatase PF01078.21 CAV25511.1 - 6e-06 25.8 0.1 0.0037 16.7 0.0 2.3 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_18 PF13238.6 CAV25511.1 - 1.4e-05 25.6 1.3 0.081 13.5 0.1 3.3 3 0 0 3 3 3 2 AAA domain AAA_16 PF13191.6 CAV25511.1 - 1.7e-05 25.3 0.1 0.09 13.2 0.1 2.6 2 1 0 2 2 2 2 AAA ATPase domain AAA_15 PF13175.6 CAV25511.1 - 4.2e-05 23.4 5.7 0.037 13.7 0.2 3.4 3 0 0 3 3 3 2 AAA ATPase domain RNA_helicase PF00910.22 CAV25511.1 - 0.00012 22.5 0.1 0.22 11.9 0.0 2.7 2 0 0 2 2 2 1 RNA helicase IstB_IS21 PF01695.17 CAV25511.1 - 0.00014 21.6 2.1 0.11 12.2 0.0 3.2 4 0 0 4 4 4 1 IstB-like ATP binding protein AAA_22 PF13401.6 CAV25511.1 - 0.00018 21.8 1.1 0.04 14.2 0.1 2.8 2 2 0 2 2 2 1 AAA domain AAA_25 PF13481.6 CAV25511.1 - 0.00072 19.2 0.5 0.45 10.1 0.0 3.5 4 0 0 4 4 4 1 AAA domain T2SSE PF00437.20 CAV25511.1 - 0.0036 16.4 0.4 0.45 9.5 0.0 2.8 3 0 0 3 3 3 1 Type II/IV secretion system protein Gtr1_RagA PF04670.12 CAV25511.1 - 0.004 16.6 2.1 2 7.7 0.0 3.4 3 0 0 3 3 3 1 Gtr1/RagA G protein conserved region AAA_5 PF07728.14 CAV25511.1 - 0.0051 16.8 0.1 2.5 8.1 0.1 2.6 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_14 PF13173.6 CAV25511.1 - 0.0057 16.7 0.0 1.2 9.2 0.0 2.7 2 0 0 2 2 2 1 AAA domain PduV-EutP PF10662.9 CAV25511.1 - 0.0062 16.3 0.4 0.16 11.7 0.0 2.5 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation G-alpha PF00503.20 CAV25511.1 - 0.007 15.6 0.1 1.5 7.9 0.0 2.5 2 1 0 2 2 2 1 G-protein alpha subunit SbcCD_C PF13558.6 CAV25511.1 - 0.0077 16.4 0.1 14 6.0 0.0 3.5 2 1 0 2 2 2 0 Putative exonuclease SbcCD, C subunit AAA_30 PF13604.6 CAV25511.1 - 0.014 15.1 0.3 4.6 6.9 0.0 2.5 2 1 0 2 2 2 0 AAA domain AAA_28 PF13521.6 CAV25511.1 - 0.015 15.5 1.9 0.55 10.4 0.2 3.2 3 0 0 3 3 3 0 AAA domain NACHT PF05729.12 CAV25511.1 - 0.017 15.0 0.7 5.2 6.9 0.1 2.5 2 0 0 2 2 2 0 NACHT domain AAA_33 PF13671.6 CAV25511.1 - 0.018 15.2 1.0 1.1 9.5 0.2 2.6 2 0 0 2 2 2 0 AAA domain MMR_HSR1 PF01926.23 CAV25511.1 - 0.019 15.0 2.6 1.5 8.9 0.3 2.8 2 1 0 2 2 2 0 50S ribosome-binding GTPase NB-ARC PF00931.22 CAV25511.1 - 0.02 14.1 1.1 1.5 8.0 0.2 2.7 2 0 0 2 2 2 0 NB-ARC domain ATP-synt_ab PF00006.25 CAV25511.1 - 0.024 14.3 0.8 5.4 6.6 0.1 2.6 2 1 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain AAA PF00004.29 CAV25511.1 - 0.027 14.9 4.3 0.72 10.3 0.0 3.4 3 1 0 3 3 2 0 ATPase family associated with various cellular activities (AAA) PRK PF00485.18 CAV25511.1 - 0.044 13.5 1.1 12 5.5 0.0 3.1 3 1 1 4 4 4 0 Phosphoribulokinase / Uridine kinase family Cytidylate_kin PF02224.18 CAV25511.1 - 0.046 13.4 0.3 2.8 7.6 0.1 2.5 2 0 0 2 2 2 0 Cytidylate kinase AAA_7 PF12775.7 CAV25511.1 - 0.047 13.2 0.6 3 7.3 0.0 2.4 2 0 0 2 2 2 0 P-loop containing dynein motor region DLIC PF05783.11 CAV25511.1 - 0.052 12.4 0.5 5.7 5.7 0.1 2.1 2 0 0 2 2 2 0 Dynein light intermediate chain (DLIC) Sigma54_activat PF00158.26 CAV25511.1 - 0.061 13.0 0.2 5.5 6.7 0.0 2.3 2 0 0 2 2 2 0 Sigma-54 interaction domain Roc PF08477.13 CAV25511.1 - 0.063 13.5 0.8 3.3 8.0 0.1 2.5 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase MeaB PF03308.16 CAV25511.1 - 0.07 12.1 0.0 1.1 8.1 0.0 2.3 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB FtsK_SpoIIIE PF01580.18 CAV25511.1 - 0.082 12.3 1.1 4.5 6.6 0.1 2.4 2 0 0 2 2 2 0 FtsK/SpoIIIE family ATPase_2 PF01637.18 CAV25511.1 - 0.11 12.4 0.2 7.1 6.5 0.1 2.6 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea ATP_bind_1 PF03029.17 CAV25511.1 - 0.18 11.6 1.8 9.3 6.0 0.1 2.8 3 0 0 3 3 3 0 Conserved hypothetical ATP binding protein AAA_13 PF13166.6 CAV25511.1 - 0.31 9.7 4.4 1.4 7.5 0.1 2.5 3 0 0 3 3 3 0 AAA domain TniB PF05621.11 CAV25511.1 - 0.79 9.1 5.4 1.4 8.3 0.0 3.3 4 0 0 4 4 3 0 Bacterial TniB protein TsaE PF02367.17 CAV25511.1 - 0.98 9.4 2.8 26 4.8 0.1 3.4 4 0 0 4 4 3 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE ATPase PF06745.13 CAV25511.1 - 1.1 8.5 4.3 5.8 6.2 0.1 2.9 3 0 0 3 3 3 0 KaiC DUF87 PF01935.17 CAV25511.1 - 2.2 8.3 7.7 2.5 8.1 0.8 3.1 4 0 0 4 4 3 0 Helicase HerA, central domain ECF-ribofla_trS PF07155.12 CAV25513.1 - 7.5e-42 143.2 20.5 7.5e-42 143.2 20.5 1.6 2 0 0 2 2 2 1 ECF-type riboflavin transporter, S component ECF_trnsprt PF12822.7 CAV25513.1 - 4e-08 33.6 21.1 4e-08 33.6 21.1 1.4 2 0 0 2 2 2 1 ECF transporter, substrate-specific component CbiM PF01891.16 CAV25513.1 - 0.055 13.3 18.2 0.075 12.9 18.2 1.2 1 0 0 1 1 1 0 Cobalt uptake substrate-specific transmembrane region HlyD_D23 PF16576.5 CAV25515.1 - 2.1e-09 36.9 0.1 8.4e-07 28.4 0.0 2.5 1 1 1 2 2 2 2 Barrel-sandwich domain of CusB or HlyD membrane-fusion Biotin_lipoyl_2 PF13533.6 CAV25515.1 - 1.5e-08 34.3 4.4 7.5e-08 32.1 0.0 3.0 3 0 0 3 3 3 1 Biotin-lipoyl like HlyD_3 PF13437.6 CAV25515.1 - 1.6e-07 32.0 0.1 0.016 15.9 0.0 2.6 2 0 0 2 2 2 2 HlyD family secretion protein HlyD PF00529.20 CAV25515.1 - 2e-05 24.4 0.1 8.9e-05 22.3 0.1 2.3 1 1 0 1 1 1 1 HlyD membrane-fusion protein of T1SS Biotin_lipoyl PF00364.22 CAV25515.1 - 0.013 15.4 0.1 0.2 11.5 0.1 2.6 2 0 0 2 2 2 0 Biotin-requiring enzyme PIGA PF08288.12 CAV25515.1 - 0.039 14.6 0.0 0.092 13.3 0.0 1.6 1 0 0 1 1 1 0 PIGA (GPI anchor biosynthesis) DUF3302 PF11742.8 CAV25517.1 - 7.8e-41 138.1 6.2 1e-40 137.7 6.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3302) ZapB PF06005.12 CAV25517.1 - 0.0015 18.9 4.5 0.0024 18.3 4.5 1.4 1 0 0 1 1 1 1 Cell division protein ZapB DUF3810 PF12725.7 CAV25517.1 - 0.0039 16.6 0.0 0.0043 16.4 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3810) DUF1465 PF07323.12 CAV25517.1 - 0.029 14.2 0.3 0.036 13.9 0.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1465) DUF998 PF06197.13 CAV25517.1 - 0.036 13.7 0.7 0.049 13.2 0.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF998) Seryl_tRNA_N PF02403.22 CAV25517.1 - 0.11 12.8 2.7 0.14 12.4 2.7 1.1 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain LPP PF04728.13 CAV25517.1 - 0.14 12.5 4.0 0.2 12.1 4.0 1.2 1 0 0 1 1 1 0 Lipoprotein leucine-zipper DUF465 PF04325.13 CAV25517.1 - 0.37 10.9 5.8 0.24 11.5 2.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF465) EamA PF00892.20 CAV25519.1 - 9.9e-28 97.0 34.9 1.8e-14 54.1 15.4 2.1 2 0 0 2 2 2 2 EamA-like transporter family Mg_trans_NIPA PF05653.14 CAV25519.1 - 0.0042 16.3 5.9 0.0051 16.0 5.4 1.5 1 1 0 1 1 1 1 Magnesium transporter NIPA DPM3 PF08285.11 CAV25519.1 - 0.017 15.3 1.1 0.017 15.3 1.1 2.5 2 0 0 2 2 2 0 Dolichol-phosphate mannosyltransferase subunit 3 (DPM3) GGDEF PF00990.21 CAV25521.1 - 1.2e-34 119.4 0.0 3.5e-34 117.9 0.0 1.9 1 0 0 1 1 1 1 Diguanylate cyclase, GGDEF domain TPR_12 PF13424.6 CAV25521.1 - 1.6e-10 41.1 1.8 0.06 13.6 0.4 4.1 3 1 0 3 3 3 3 Tetratricopeptide repeat TPR_MalT PF17874.1 CAV25521.1 - 1.2e-07 31.4 0.6 2.2e-07 30.6 0.6 1.5 1 0 0 1 1 1 1 MalT-like TPR region TPR_1 PF00515.28 CAV25521.1 - 5.4e-05 22.8 2.6 0.28 11.1 0.1 3.9 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.17 CAV25521.1 - 0.00011 22.1 4.9 4.1 7.7 0.1 4.4 5 0 0 5 5 4 3 Tetratricopeptide repeat TPR_7 PF13176.6 CAV25521.1 - 0.00096 19.0 0.2 2.5 8.3 0.1 3.3 2 0 0 2 2 2 2 Tetratricopeptide repeat RPN7 PF10602.9 CAV25521.1 - 0.004 16.9 0.4 0.004 16.9 0.4 2.4 2 1 1 3 3 3 1 26S proteasome subunit RPN7 TPR_19 PF14559.6 CAV25521.1 - 0.013 16.0 1.3 20 5.8 0.0 4.4 3 2 2 5 5 5 0 Tetratricopeptide repeat TPR_21 PF09976.9 CAV25521.1 - 0.041 13.6 0.1 0.14 11.8 0.1 1.9 1 0 0 1 1 1 0 Tetratricopeptide repeat-like domain TPR_6 PF13174.6 CAV25521.1 - 0.078 13.7 1.2 11 6.8 0.0 3.7 3 0 0 3 3 2 0 Tetratricopeptide repeat TPR_8 PF13181.6 CAV25521.1 - 6.2 7.3 8.5 12 6.4 0.0 4.6 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_12 PF13424.6 CAV25523.1 - 6.5e-07 29.6 21.4 0.1 12.9 0.3 4.6 3 1 1 4 4 4 4 Tetratricopeptide repeat TPR_2 PF07719.17 CAV25523.1 - 0.0046 17.0 25.4 0.045 13.9 0.3 6.9 7 0 0 7 7 7 2 Tetratricopeptide repeat DUF3632 PF12311.8 CAV25523.1 - 0.051 14.0 1.5 0.083 13.3 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3632) TPR_16 PF13432.6 CAV25523.1 - 0.15 12.8 11.7 9.1 7.0 2.3 5.0 5 1 1 6 6 6 0 Tetratricopeptide repeat TPR_8 PF13181.6 CAV25523.1 - 0.18 12.1 10.1 9.6 6.7 0.3 4.6 4 0 0 4 4 4 0 Tetratricopeptide repeat ANAPC3 PF12895.7 CAV25523.1 - 0.97 9.7 13.2 1.3 9.3 0.1 4.9 3 2 2 5 5 5 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_1 PF00515.28 CAV25523.1 - 2.6 8.0 15.1 16 5.5 0.0 5.8 6 0 0 6 6 6 0 Tetratricopeptide repeat Terminase_5 PF06056.12 CAV25526.1 - 0.0077 16.1 0.0 0.033 14.1 0.0 2.1 2 0 0 2 2 2 1 Putative ATPase subunit of terminase (gpP-like) HTH_28 PF13518.6 CAV25526.1 - 0.018 15.2 0.0 0.056 13.6 0.0 1.8 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_23 PF13384.6 CAV25526.1 - 0.019 14.7 0.0 0.15 11.9 0.0 2.6 2 0 0 2 2 2 0 Homeodomain-like domain HTH_Tnp_1 PF01527.20 CAV25526.1 - 0.041 14.2 0.0 0.16 12.3 0.0 2.0 1 0 0 1 1 1 0 Transposase Zn_ribbon_SprT PF17283.2 CAV25526.1 - 0.064 13.2 5.2 0.065 13.1 0.7 3.0 3 1 0 3 3 3 0 SprT-like zinc ribbon domain Zn-ribbon_8 PF09723.10 CAV25526.1 - 0.067 13.3 1.2 4.5 7.5 0.1 2.6 2 0 0 2 2 2 0 Zinc ribbon domain A2L_zn_ribbon PF08792.10 CAV25526.1 - 0.12 12.2 0.9 38 4.1 0.1 3.6 3 0 0 3 3 3 0 A2L zinc ribbon domain HTH_29 PF13551.6 CAV25526.1 - 0.12 12.4 0.0 0.4 10.7 0.0 1.8 1 0 0 1 1 1 0 Winged helix-turn helix PNP_UDP_1 PF01048.20 CAV25528.1 - 2.3e-35 122.0 0.6 2.7e-35 121.7 0.6 1.0 1 0 0 1 1 1 1 Phosphorylase superfamily MAGI_u1 PF16663.5 CAV25528.1 - 0.12 12.4 0.1 0.49 10.5 0.0 1.9 2 0 0 2 2 2 0 Unstructured region on MAGI YkuD PF03734.14 CAV25529.1 - 1.1e-21 77.8 0.0 1.6e-21 77.3 0.0 1.2 1 0 0 1 1 1 1 L,D-transpeptidase catalytic domain Ldt_C PF17969.1 CAV25529.1 - 3.1e-19 69.5 0.0 4.8e-19 68.8 0.0 1.3 1 0 0 1 1 1 1 L,D-transpeptidase C-terminal domain LysM PF01476.20 CAV25529.1 - 1.5e-06 28.1 0.0 2.5e-06 27.4 0.0 1.4 1 0 0 1 1 1 1 LysM domain LPP PF04728.13 CAV25531.1 - 6.3e-19 68.1 7.5 9.5e-19 67.5 7.5 1.3 1 0 0 1 1 1 1 Lipoprotein leucine-zipper Alanine_zipper PF11839.8 CAV25531.1 - 2.6e-07 30.9 19.7 3.5e-07 30.5 19.7 1.2 1 0 0 1 1 1 1 Alanine-zipper, major outer membrane lipoprotein ADIP PF11559.8 CAV25531.1 - 0.00018 21.6 2.7 0.00025 21.2 2.7 1.2 1 0 0 1 1 1 1 Afadin- and alpha -actinin-Binding DUF3138 PF11336.8 CAV25531.1 - 0.0023 16.6 9.1 0.0028 16.4 9.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3138) ZapB PF06005.12 CAV25531.1 - 0.0048 17.3 3.1 0.0073 16.7 3.1 1.2 1 0 0 1 1 1 1 Cell division protein ZapB JIP_LZII PF16471.5 CAV25531.1 - 0.013 15.6 0.6 0.028 14.6 0.5 1.6 1 1 0 1 1 1 0 JNK-interacting protein leucine zipper II DUF2443 PF10398.9 CAV25531.1 - 0.053 13.6 0.1 0.078 13.0 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2443) DivIC PF04977.15 CAV25531.1 - 0.056 13.2 1.9 0.068 13.0 0.7 1.7 1 1 1 2 2 2 0 Septum formation initiator Gln-synt_N_2 PF16952.5 CAV25531.1 - 0.062 13.1 0.1 0.073 12.9 0.1 1.1 1 0 0 1 1 1 0 Glutamine synthetase N-terminal domain DUF4995 PF16386.5 CAV25531.1 - 0.087 12.8 0.6 0.14 12.2 0.4 1.5 1 1 0 1 1 1 0 Domain of unknown function LPAM_1 PF08139.12 CAV25531.1 - 0.16 12.5 1.2 0.16 12.5 1.2 2.0 2 0 0 2 2 2 0 Prokaryotic membrane lipoprotein lipid attachment site DEAD PF00270.29 CAV25533.1 - 1.1e-47 162.1 0.0 1.2e-46 158.7 0.0 2.2 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CAV25533.1 - 4.2e-32 110.8 1.1 7.9e-31 106.7 0.3 2.4 1 1 1 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 CAV25533.1 - 3.7e-07 30.3 0.4 1.4e-06 28.4 0.0 2.1 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 CAV25533.1 - 0.0091 15.2 0.0 0.015 14.5 0.0 1.4 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase UTP25 PF06862.12 CAV25533.1 - 0.0094 14.8 0.5 0.098 11.4 0.4 2.6 3 1 0 3 3 3 1 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 AAA_22 PF13401.6 CAV25533.1 - 0.034 14.4 0.3 0.15 12.3 0.3 2.1 1 1 0 1 1 1 0 AAA domain SecA_DEAD PF07517.14 CAV25533.1 - 0.065 12.5 0.1 0.2 10.9 0.0 1.8 2 0 0 2 2 2 0 SecA DEAD-like domain Flavi_DEAD PF07652.14 CAV25533.1 - 0.12 12.3 0.1 0.61 10.0 0.0 2.1 2 0 0 2 2 2 0 Flavivirus DEAD domain Lipase_GDSL PF00657.22 CAV25535.1 - 3e-16 60.0 0.5 4.2e-16 59.5 0.5 1.2 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Abhydrolase_1 PF00561.20 CAV25536.1 - 1.2e-14 54.6 0.1 1.8e-14 54.0 0.1 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Palm_thioest PF02089.15 CAV25536.1 - 2e-07 31.1 0.0 2.3e-07 30.9 0.0 1.2 1 0 0 1 1 1 1 Palmitoyl protein thioesterase Lipase_2 PF01674.18 CAV25536.1 - 0.00039 20.0 0.5 0.00076 19.1 0.5 1.5 1 1 0 1 1 1 1 Lipase (class 2) Lipase_3 PF01764.25 CAV25536.1 - 0.015 15.1 0.1 0.027 14.3 0.1 1.3 1 0 0 1 1 1 0 Lipase (class 3) Abhydrolase_6 PF12697.7 CAV25536.1 - 0.04 14.5 0.3 0.047 14.3 0.3 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase family DUF2974 PF11187.8 CAV25536.1 - 0.062 12.9 0.1 0.09 12.3 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) DUF676 PF05057.14 CAV25536.1 - 0.084 12.4 0.0 0.14 11.7 0.0 1.4 1 0 0 1 1 1 0 Putative serine esterase (DUF676) Esterase PF00756.20 CAV25536.1 - 0.11 12.2 0.1 0.14 11.8 0.1 1.3 1 0 0 1 1 1 0 Putative esterase LCAT PF02450.15 CAV25536.1 - 0.11 11.6 0.0 0.16 11.1 0.0 1.1 1 0 0 1 1 1 0 Lecithin:cholesterol acyltransferase UPF0227 PF05728.12 CAV25536.1 - 0.11 12.4 0.0 0.18 11.8 0.0 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0227) LIP PF03583.14 CAV25536.1 - 0.16 11.3 1.3 0.25 10.6 1.3 1.3 1 0 0 1 1 1 0 Secretory lipase PGAP1 PF07819.13 CAV25536.1 - 0.25 11.0 0.8 0.31 10.7 0.1 1.5 2 0 0 2 2 2 0 PGAP1-like protein Lipase_chap PF03280.14 CAV25538.1 - 6.2e-47 160.1 19.9 1e-46 159.4 19.9 1.3 1 0 0 1 1 1 1 Proteobacterial lipase chaperone protein DUF1456 PF07308.13 CAV25538.1 - 0.095 13.1 0.3 1.1 9.7 0.1 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF1456) CT_C_D PF02682.16 CAV25538.1 - 0.39 10.4 1.4 0.41 10.4 0.2 1.8 2 0 0 2 2 2 0 Carboxyltransferase domain, subdomain C and D MCPsignal PF00015.21 CAV25540.1 - 1e-41 142.6 47.2 2.6e-41 141.3 23.5 4.2 2 1 2 4 4 4 2 Methyl-accepting chemotaxis protein (MCP) signalling domain HAMP PF00672.25 CAV25540.1 - 6.1e-11 42.5 3.3 9.4e-10 38.7 0.1 4.0 4 0 0 4 4 4 1 HAMP domain Spore_III_AB PF09548.10 CAV25540.1 - 0.04 14.0 6.0 0.09 12.9 1.6 3.0 3 1 0 3 3 3 0 Stage III sporulation protein AB (spore_III_AB) DUF3479 PF11965.8 CAV25540.1 - 0.15 12.2 10.1 0.19 11.8 6.8 2.8 2 1 0 2 2 2 0 Domain of unknown function (DUF3479) Fungal_TACC PF12709.7 CAV25540.1 - 0.56 10.7 0.1 0.56 10.7 0.1 5.3 5 2 1 6 6 6 0 Fungal Transforming acidic coiled-coil (TACC) proteins Vip3A_N PF12495.8 CAV25540.1 - 1.1 9.1 13.6 0.09 12.7 1.0 3.0 2 1 1 3 3 3 0 Vegetative insecticide protein 3A N terminal DUF2400 PF09674.10 CAV25540.1 - 5.9 6.8 10.0 12 5.8 0.9 3.5 1 1 0 3 3 3 0 Protein of unknown function (DUF2400) BLOC1_2 PF10046.9 CAV25540.1 - 6.3 7.2 32.8 5.1 7.5 1.9 6.7 5 2 2 8 8 8 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 PBP_like_2 PF12849.7 CAV25542.1 - 7.2e-41 140.7 6.2 1.6e-40 139.6 6.2 1.5 1 1 0 1 1 1 1 PBP superfamily domain PBP_like PF12727.7 CAV25542.1 - 4.1e-26 91.3 0.2 5.4e-26 90.9 0.2 1.1 1 0 0 1 1 1 1 PBP superfamily domain SBP_bac_11 PF13531.6 CAV25542.1 - 4.3e-07 29.9 0.2 5.4e-07 29.6 0.2 1.1 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_1 PF01547.25 CAV25542.1 - 3.8e-05 23.8 3.4 6.3e-05 23.1 3.4 1.3 1 1 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_8 PF13416.6 CAV25542.1 - 0.0089 15.9 0.0 0.015 15.1 0.0 1.4 1 1 0 1 1 1 1 Bacterial extracellular solute-binding protein BPD_transp_1 PF00528.22 CAV25544.1 - 7e-23 81.3 22.2 7e-23 81.3 22.2 2.3 1 1 0 2 2 2 1 Binding-protein-dependent transport system inner membrane component DUF3333 PF11812.8 CAV25544.1 - 0.075 13.2 0.4 0.075 13.2 0.4 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF3333) CrgA PF06781.12 CAV25544.1 - 0.11 12.6 0.8 0.5 10.5 0.1 2.6 2 1 0 2 2 2 0 Cell division protein CrgA BPD_transp_1 PF00528.22 CAV25546.1 - 1e-26 93.8 15.5 1e-26 93.8 15.5 2.4 1 1 0 2 2 2 1 Binding-protein-dependent transport system inner membrane component PBP_N PF17093.5 CAV25546.1 - 0.23 11.7 0.5 0.49 10.7 0.5 1.5 1 0 0 1 1 1 0 Penicillin-binding protein N-terminus DUF4307 PF14155.6 CAV25546.1 - 1.4 8.8 3.0 1.5 8.7 0.0 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF4307) ABC_tran PF00005.27 CAV25548.1 - 1.5e-29 103.3 0.0 2.2e-29 102.7 0.0 1.3 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 CAV25548.1 - 4.6e-14 52.9 0.1 1.9e-06 27.9 0.0 2.1 1 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 CAV25548.1 - 6.1e-08 32.4 0.1 3.5e-06 26.6 0.1 2.2 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 CAV25548.1 - 5.9e-05 23.4 0.1 0.0002 21.6 0.1 1.9 1 1 0 1 1 1 1 AAA domain RsgA_GTPase PF03193.16 CAV25548.1 - 0.00013 22.0 0.0 0.00039 20.4 0.0 1.8 2 0 0 2 2 2 1 RsgA GTPase AAA_15 PF13175.6 CAV25548.1 - 0.00016 21.5 0.0 0.0027 17.5 0.0 2.0 1 1 0 2 2 2 1 AAA ATPase domain Rad17 PF03215.15 CAV25548.1 - 0.00023 21.2 0.0 0.00048 20.1 0.0 1.5 1 0 0 1 1 1 1 Rad17 P-loop domain AAA_23 PF13476.6 CAV25548.1 - 0.00026 21.6 0.0 0.00062 20.3 0.0 1.6 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 CAV25548.1 - 0.00078 19.9 0.0 0.0027 18.1 0.0 1.8 2 0 0 2 2 2 1 AAA ATPase domain AAA_29 PF13555.6 CAV25548.1 - 0.00087 19.0 0.0 0.0017 18.1 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_18 PF13238.6 CAV25548.1 - 0.0032 18.0 0.3 0.017 15.7 0.3 2.1 1 1 0 1 1 1 1 AAA domain AAA_30 PF13604.6 CAV25548.1 - 0.0048 16.6 0.1 0.13 12.0 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA PF00004.29 CAV25548.1 - 0.0051 17.2 0.3 0.065 13.7 0.3 2.3 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_25 PF13481.6 CAV25548.1 - 0.0071 15.9 0.0 0.037 13.6 0.0 2.0 2 0 0 2 2 2 1 AAA domain ATPase_2 PF01637.18 CAV25548.1 - 0.014 15.3 0.0 0.86 9.5 0.0 2.2 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea ABC_ATPase PF09818.9 CAV25548.1 - 0.016 14.0 0.0 3.6 6.3 0.0 2.1 2 0 0 2 2 2 0 Predicted ATPase of the ABC class AAA_19 PF13245.6 CAV25548.1 - 0.023 15.1 0.1 2.8 8.3 0.0 2.3 2 0 0 2 2 2 0 AAA domain Adeno_IVa2 PF02456.15 CAV25548.1 - 0.03 13.1 0.1 0.072 11.9 0.0 1.6 2 0 0 2 2 2 0 Adenovirus IVa2 protein AAA_28 PF13521.6 CAV25548.1 - 0.058 13.6 0.1 0.14 12.4 0.1 1.6 1 0 0 1 1 1 0 AAA domain NB-ARC PF00931.22 CAV25548.1 - 0.063 12.4 0.0 0.075 12.2 0.0 1.5 1 1 0 1 1 1 0 NB-ARC domain AAA_33 PF13671.6 CAV25548.1 - 0.072 13.3 0.1 0.16 12.1 0.0 1.6 2 0 0 2 2 1 0 AAA domain AAA_14 PF13173.6 CAV25548.1 - 0.078 13.0 0.1 0.24 11.4 0.1 2.1 1 1 0 1 1 1 0 AAA domain AAA_5 PF07728.14 CAV25548.1 - 0.081 12.9 0.0 0.28 11.2 0.0 1.9 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_24 PF13479.6 CAV25548.1 - 0.088 12.5 0.1 0.52 10.0 0.0 2.1 2 1 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 CAV25548.1 - 0.11 12.8 0.1 0.92 9.9 0.0 2.4 2 1 0 2 2 2 0 RNA helicase NACHT PF05729.12 CAV25548.1 - 0.13 12.2 0.1 0.35 10.8 0.0 1.7 2 0 0 2 2 2 0 NACHT domain GGDEF PF00990.21 CAV25549.1 - 1.1e-34 119.5 2.3 3.3e-34 118.0 0.1 2.6 3 0 0 3 3 3 1 Diguanylate cyclase, GGDEF domain GAF PF01590.26 CAV25549.1 - 0.00028 21.5 0.1 0.59 10.8 0.0 3.0 2 1 0 2 2 2 2 GAF domain Matrilin_ccoil PF10393.9 CAV25549.1 - 0.11 12.3 3.3 0.34 10.8 3.3 1.8 1 0 0 1 1 1 0 Trimeric coiled-coil oligomerisation domain of matrilin BatD PF13584.6 CAV25551.1 - 1.6e-71 241.6 11.9 2.6e-71 240.9 11.9 1.2 1 0 0 1 1 1 1 Oxygen tolerance TRAPPC10 PF12584.8 CAV25551.1 - 0.007 16.1 0.0 3.4 7.3 0.0 2.7 2 1 0 2 2 2 2 Trafficking protein particle complex subunit 10, TRAPPC10 VWA_2 PF13519.6 CAV25553.1 - 1e-11 45.4 3.1 2.6e-11 44.1 0.0 3.0 3 0 0 3 3 3 1 von Willebrand factor type A domain TPR_1 PF00515.28 CAV25553.1 - 6.9e-08 32.0 11.7 7.7e-08 31.8 1.4 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.17 CAV25553.1 - 8.8e-08 31.7 12.2 1.7e-06 27.7 1.1 3.8 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_16 PF13432.6 CAV25553.1 - 2.1e-07 31.5 8.1 6.7e-06 26.7 0.4 4.2 3 1 0 4 4 4 1 Tetratricopeptide repeat TPR_19 PF14559.6 CAV25553.1 - 1.1e-06 29.1 4.3 1.1e-06 29.1 4.3 4.0 2 1 1 3 3 2 1 Tetratricopeptide repeat TPR_6 PF13174.6 CAV25553.1 - 1.5e-05 25.3 0.4 1.5e-05 25.3 0.4 4.0 4 0 0 4 4 3 1 Tetratricopeptide repeat TPR_8 PF13181.6 CAV25553.1 - 3.1e-05 23.8 2.6 0.00021 21.2 0.6 3.0 2 0 0 2 2 2 1 Tetratricopeptide repeat ANAPC3 PF12895.7 CAV25553.1 - 0.00031 20.9 2.3 0.0013 19.0 1.5 2.3 1 1 1 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 3 Fis1_TPR_C PF14853.6 CAV25553.1 - 0.00033 20.7 2.1 0.0057 16.7 0.9 2.4 2 0 0 2 2 2 1 Fis1 C-terminal tetratricopeptide repeat TPR_14 PF13428.6 CAV25553.1 - 0.00038 21.0 5.3 0.0014 19.3 0.2 3.5 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_4 PF07721.14 CAV25553.1 - 0.00049 20.5 2.3 0.52 11.1 0.0 3.3 3 0 0 3 3 2 2 Tetratricopeptide repeat TPR_7 PF13176.6 CAV25553.1 - 0.00097 19.0 0.4 0.00097 19.0 0.4 3.3 2 1 1 3 3 3 1 Tetratricopeptide repeat Borrelia_P83 PF05262.11 CAV25553.1 - 0.004 15.7 22.6 0.005 15.4 22.6 1.3 1 0 0 1 1 1 1 Borrelia P83/100 protein TPR_11 PF13414.6 CAV25553.1 - 0.014 15.1 2.2 0.014 15.1 2.2 3.3 3 1 1 4 4 4 0 TPR repeat TPR_12 PF13424.6 CAV25553.1 - 0.023 15.0 0.8 0.023 15.0 0.8 3.4 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_10 PF13374.6 CAV25553.1 - 0.03 14.2 0.9 0.03 14.2 0.9 2.7 3 0 0 3 3 2 0 Tetratricopeptide repeat TPR_17 PF13431.6 CAV25553.1 - 0.044 14.2 6.6 0.18 12.2 0.7 3.7 3 0 0 3 3 3 0 Tetratricopeptide repeat SDA1 PF05285.12 CAV25553.1 - 0.57 9.6 42.0 0.82 9.0 42.0 1.3 1 0 0 1 1 1 0 SDA1 TPR_9 PF13371.6 CAV25553.1 - 3.7 7.8 7.2 2.7 8.2 0.3 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_3 PF07720.12 CAV25553.1 - 6.7 6.8 16.7 4.9 7.3 1.6 3.8 3 0 0 3 3 3 0 Tetratricopeptide repeat Otopetrin PF03189.13 CAV25553.1 - 10 4.8 6.7 23 3.6 0.0 2.3 1 1 1 2 2 1 0 Otopetrin VWA PF00092.28 CAV25554.1 - 7.6e-34 117.5 0.4 9.3e-34 117.2 0.4 1.1 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.6 CAV25554.1 - 1.1e-18 67.8 0.7 2.2e-18 66.9 0.2 1.6 2 0 0 2 2 2 1 von Willebrand factor type A domain DUF1194 PF06707.11 CAV25554.1 - 5.1e-05 22.6 1.2 0.00059 19.1 1.2 2.1 1 1 0 1 1 1 1 Protein of unknown function (DUF1194) BatA PF07584.11 CAV25554.1 - 0.023 15.1 3.9 0.023 15.1 3.9 1.9 2 0 0 2 2 2 0 Aerotolerance regulator N-terminal DUF4381 PF14316.6 CAV25556.1 - 9.5e-38 129.7 9.7 1.1e-37 129.5 9.7 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4381) Lig_chan PF00060.26 CAV25556.1 - 0.0098 15.7 0.5 0.011 15.6 0.5 1.3 1 1 0 1 1 1 1 Ligand-gated ion channel FeoB_associated PF12669.7 CAV25556.1 - 0.027 14.9 1.4 0.043 14.2 1.4 1.2 1 0 0 1 1 1 0 FeoB-associated Cys-rich membrane protein OATP PF03137.20 CAV25556.1 - 0.038 12.3 0.4 0.041 12.2 0.4 1.1 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family Orf78 PF06024.12 CAV25556.1 - 0.18 12.1 0.7 0.34 11.2 0.1 1.7 2 0 0 2 2 2 0 Orf78 (ac78) DUF3810 PF12725.7 CAV25556.1 - 0.18 11.1 0.2 0.31 10.4 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3810) YajC PF02699.15 CAV25556.1 - 0.56 10.1 2.3 0.41 10.6 0.5 1.6 2 0 0 2 2 2 0 Preprotein translocase subunit DUF58 PF01882.18 CAV25558.1 - 7.8e-22 77.4 0.0 1.6e-21 76.4 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function DUF58 VWA_CoxE PF05762.14 CAV25558.1 - 0.0039 16.6 0.0 0.031 13.7 0.0 2.1 1 1 0 1 1 1 1 VWA domain containing CoxE-like protein AAA_3 PF07726.11 CAV25560.1 - 2e-63 212.1 0.3 6.8e-63 210.4 0.0 1.9 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_lid_2 PF17863.1 CAV25560.1 - 2.3e-21 75.4 1.1 6.1e-21 74.0 1.1 1.8 1 0 0 1 1 1 1 AAA lid domain AAA_5 PF07728.14 CAV25560.1 - 2.4e-10 40.6 0.0 4.9e-10 39.5 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) MCM PF00493.23 CAV25560.1 - 6.3e-06 25.4 0.0 9.5e-06 24.9 0.0 1.2 1 0 0 1 1 1 1 MCM P-loop domain Sigma54_activat PF00158.26 CAV25560.1 - 8.7e-05 22.3 0.0 0.00032 20.5 0.0 1.8 1 1 0 1 1 1 1 Sigma-54 interaction domain RuvB_N PF05496.12 CAV25560.1 - 0.0024 17.6 0.0 0.045 13.5 0.0 2.3 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain Mg_chelatase PF01078.21 CAV25560.1 - 0.0026 17.2 0.1 0.06 12.7 0.1 2.2 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA PF00004.29 CAV25560.1 - 0.036 14.5 0.0 0.25 11.8 0.0 2.4 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) MCM_lid PF17855.1 CAV25560.1 - 0.056 13.9 0.1 0.11 13.0 0.1 1.4 1 0 0 1 1 1 0 MCM AAA-lid domain MCPsignal PF00015.21 CAV25561.1 - 2.7e-42 144.5 21.9 2.7e-42 144.5 21.9 3.6 2 1 2 4 4 4 3 Methyl-accepting chemotaxis protein (MCP) signalling domain HAMP PF00672.25 CAV25561.1 - 2.9e-12 46.8 3.9 2.9e-11 43.6 0.0 4.3 5 0 0 5 5 5 1 HAMP domain dCache_1 PF02743.18 CAV25561.1 - 5.7e-08 32.8 2.7 5.7e-08 32.8 2.7 3.5 3 1 1 4 4 4 1 Cache domain DUF2120 PF09893.9 CAV25561.1 - 0.043 13.9 6.5 1.1 9.4 1.3 3.3 2 2 1 3 3 3 0 Uncharacterized protein conserved in archaea (DUF2120) Nup54 PF13874.6 CAV25561.1 - 0.043 13.9 0.9 0.043 13.9 0.9 3.6 3 1 0 3 3 3 0 Nucleoporin complex subunit 54 AAA_5 PF07728.14 CAV25561.1 - 0.085 12.9 3.7 0.35 10.9 0.3 3.1 2 1 1 3 3 3 0 AAA domain (dynein-related subfamily) UPF0016 PF01169.19 CAV25561.1 - 0.25 11.7 3.3 0.33 11.3 0.1 2.4 2 0 0 2 2 2 0 Uncharacterized protein family UPF0016 DUF4200 PF13863.6 CAV25561.1 - 0.38 11.2 6.3 6.9 7.1 0.4 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF4200) HMMR_N PF15905.5 CAV25561.1 - 4.5 6.6 13.6 5.4 6.4 2.8 2.6 2 1 0 2 2 2 0 Hyaluronan mediated motility receptor N-terminal Sec20 PF03908.13 CAV25561.1 - 6.8 6.7 7.4 6.9 6.7 0.1 4.2 2 2 1 4 4 4 0 Sec20 TrbI_Ftype PF09677.10 CAV25563.1 - 0.013 15.8 0.1 0.048 14.0 0.0 1.7 1 1 1 2 2 2 0 Type-F conjugative transfer system protein (TrbI_Ftype) Methylase_S PF01420.19 CAV25563.1 - 0.031 14.5 0.2 0.033 14.4 0.2 1.2 1 0 0 1 1 1 0 Type I restriction modification DNA specificity domain FliG_C PF01706.16 CAV25563.1 - 0.072 13.3 0.2 0.093 12.9 0.2 1.1 1 0 0 1 1 1 0 FliG C-terminal domain ABC_tran PF00005.27 CAV25566.1 - 9e-33 113.7 0.0 1.6e-32 112.9 0.0 1.4 1 0 0 1 1 1 1 ABC transporter TOBE_2 PF08402.10 CAV25566.1 - 3.2e-10 40.0 0.0 1.4e-09 38.0 0.0 2.1 2 0 0 2 2 2 1 TOBE domain OB_MalK PF17912.1 CAV25566.1 - 1.4e-09 38.6 0.1 9e-09 36.0 0.0 2.4 2 0 0 2 2 2 1 MalK OB fold domain AAA_21 PF13304.6 CAV25566.1 - 4.7e-07 29.9 0.0 0.00029 20.7 0.0 2.2 1 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 CAV25566.1 - 3.4e-06 26.7 0.1 0.031 13.7 0.0 2.3 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 CAV25566.1 - 5.8e-05 23.7 0.0 0.0001 22.9 0.0 1.4 1 0 0 1 1 1 1 AAA domain RsgA_GTPase PF03193.16 CAV25566.1 - 6e-05 23.0 0.1 0.00035 20.5 0.0 2.0 2 0 0 2 2 2 1 RsgA GTPase AAA_16 PF13191.6 CAV25566.1 - 0.00077 19.9 0.1 0.0013 19.1 0.1 1.6 1 1 0 1 1 1 1 AAA ATPase domain AAA_25 PF13481.6 CAV25566.1 - 0.0011 18.6 0.0 0.06 12.9 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_29 PF13555.6 CAV25566.1 - 0.0012 18.5 0.0 0.0025 17.5 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_15 PF13175.6 CAV25566.1 - 0.0019 18.0 0.0 0.0026 17.5 0.0 1.3 1 0 0 1 1 1 1 AAA ATPase domain AAA_33 PF13671.6 CAV25566.1 - 0.0034 17.6 0.0 0.048 13.8 0.0 2.3 2 0 0 2 2 2 1 AAA domain MIT_C PF16565.5 CAV25566.1 - 0.01 15.8 0.0 0.019 15.0 0.0 1.3 1 0 0 1 1 1 0 Phospholipase D-like domain at C-terminus of MIT AAA_22 PF13401.6 CAV25566.1 - 0.019 15.3 0.1 0.051 13.9 0.0 1.7 2 0 0 2 2 2 0 AAA domain TOBE PF03459.17 CAV25566.1 - 0.029 14.7 0.0 0.095 13.0 0.0 1.9 2 0 0 2 2 2 0 TOBE domain Rad17 PF03215.15 CAV25566.1 - 0.046 13.6 0.0 0.071 13.0 0.0 1.3 1 0 0 1 1 1 0 Rad17 P-loop domain ATPase_2 PF01637.18 CAV25566.1 - 0.048 13.6 0.0 0.073 13.0 0.0 1.3 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea AAA PF00004.29 CAV25566.1 - 0.084 13.3 0.0 0.21 12.0 0.0 1.7 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) MMR_HSR1 PF01926.23 CAV25566.1 - 0.085 13.0 0.0 0.2 11.7 0.0 1.6 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_28 PF13521.6 CAV25566.1 - 0.091 13.0 0.2 0.27 11.5 0.1 1.8 2 0 0 2 2 2 0 AAA domain NACHT PF05729.12 CAV25566.1 - 0.094 12.6 0.1 0.23 11.4 0.0 1.7 2 0 0 2 2 2 0 NACHT domain SBP_bac_8 PF13416.6 CAV25568.1 - 7.8e-42 144.0 9.1 7.8e-42 144.0 9.1 1.4 1 1 1 2 2 2 1 Bacterial extracellular solute-binding protein SBP_bac_1 PF01547.25 CAV25568.1 - 6.5e-37 128.1 16.2 8.3e-37 127.8 16.2 1.1 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein FlgD_ig PF13860.6 CAV25568.1 - 0.023 14.6 0.1 0.15 12.0 0.0 2.4 2 0 0 2 2 2 0 FlgD Ig-like domain MalF_P2 PF14785.6 CAV25570.1 - 6.6e-58 195.4 0.0 8.3e-58 195.0 0.0 1.1 1 0 0 1 1 1 1 Maltose transport system permease protein MalF P2 domain BPD_transp_1 PF00528.22 CAV25570.1 - 2.1e-17 63.5 16.7 2.1e-17 63.5 16.7 2.6 2 1 0 2 2 2 1 Binding-protein-dependent transport system inner membrane component TM_PBP2_N PF16296.5 CAV25570.1 - 0.00093 19.3 0.1 0.00093 19.3 0.1 2.6 3 0 0 3 3 3 1 N-terminal of TM subunit in PBP-dependent ABC transporters DUF4534 PF15049.6 CAV25570.1 - 0.015 15.1 0.5 0.045 13.5 0.5 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF4534) MTABC_N PF16185.5 CAV25570.1 - 0.25 10.8 2.5 0.14 11.7 0.3 1.6 2 0 0 2 2 2 0 Mitochondrial ABC-transporter N-terminal five TM region BPD_transp_1 PF00528.22 CAV25572.1 - 4.9e-18 65.5 15.3 4.9e-18 65.5 15.3 2.1 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component SUR7 PF06687.12 CAV25572.1 - 2.7 7.6 12.0 0.94 9.1 5.0 2.3 2 0 0 2 2 2 0 SUR7/PalI family DUF2933 PF11666.8 CAV25572.1 - 6.2 6.9 7.4 2.3 8.3 0.3 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF2933) FTO_CTD PF12934.7 CAV25573.1 - 0.13 12.0 0.0 0.17 11.7 0.0 1.1 1 0 0 1 1 1 0 FTO C-terminal domain 4HBT PF03061.22 CAV25575.1 - 2.5e-16 59.8 0.1 4.3e-16 59.0 0.1 1.4 1 0 0 1 1 1 1 Thioesterase superfamily 4HBT_2 PF13279.6 CAV25575.1 - 0.044 14.3 0.0 0.056 13.9 0.0 1.2 1 0 0 1 1 1 0 Thioesterase-like superfamily EamA PF00892.20 CAV25577.1 - 9e-39 132.8 36.8 4.5e-20 72.2 16.1 2.0 2 0 0 2 2 2 2 EamA-like transporter family HTH_18 PF12833.7 CAV25579.1 - 4.6e-20 71.7 0.3 7.2e-20 71.0 0.3 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 CAV25579.1 - 2.5e-13 49.8 0.0 4.5e-07 29.8 0.0 2.4 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family AraC_binding PF02311.19 CAV25579.1 - 0.00094 19.1 0.1 0.0014 18.5 0.1 1.2 1 0 0 1 1 1 1 AraC-like ligand binding domain DUF4164 PF13747.6 CAV25582.1 - 0.067 13.5 0.1 0.08 13.2 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4164) Alkyl_sulf_dimr PF14863.6 CAV25584.1 - 5.9e-37 127.2 0.2 1.3e-36 126.1 0.2 1.6 1 0 0 1 1 1 1 Alkyl sulfatase dimerisation Lactamase_B PF00753.27 CAV25584.1 - 1.4e-09 38.2 0.9 3.6e-09 36.9 0.9 1.8 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Alkyl_sulf_C PF14864.6 CAV25584.1 - 0.00011 22.5 0.0 0.00021 21.5 0.0 1.4 1 0 0 1 1 1 1 Alkyl sulfatase C-terminal Serine_protease PF18405.1 CAV25584.1 - 0.086 12.0 0.1 0.16 11.1 0.1 1.3 1 0 0 1 1 1 0 Gammaproteobacterial serine protease Abhydrolase_3 PF07859.13 CAV25586.1 - 1.5e-43 149.1 0.0 2e-43 148.7 0.0 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 CAV25586.1 - 7.5e-07 28.8 0.0 0.0034 16.9 0.0 2.2 2 0 0 2 2 2 2 Prolyl oligopeptidase family Say1_Mug180 PF10340.9 CAV25586.1 - 7.8e-07 28.3 0.0 1.3e-06 27.6 0.0 1.3 1 0 0 1 1 1 1 Steryl acetyl hydrolase Thioesterase PF00975.20 CAV25586.1 - 0.00042 20.5 0.0 0.00065 19.9 0.0 1.3 1 0 0 1 1 1 1 Thioesterase domain Hydrolase_4 PF12146.8 CAV25586.1 - 0.0022 17.3 0.0 0.17 11.1 0.0 2.2 2 0 0 2 2 2 2 Serine aminopeptidase, S33 AlaDh_PNT_C PF01262.21 CAV25586.1 - 0.017 14.4 0.0 0.025 13.9 0.0 1.2 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain MS_channel PF00924.18 CAV25587.1 - 4.3e-36 124.4 0.2 8e-36 123.5 0.1 1.5 1 1 1 2 2 2 1 Mechanosensitive ion channel ATP-grasp_5 PF13549.6 CAV25587.1 - 0.061 12.8 0.3 0.35 10.3 0.0 2.0 2 0 0 2 2 2 0 ATP-grasp domain HTH_1 PF00126.27 CAV25589.1 - 2.8e-16 59.2 0.3 4.8e-16 58.5 0.3 1.4 1 0 0 1 1 1 1 Bacterial regulatory helix-turn-helix protein, lysR family LysR_substrate PF03466.20 CAV25589.1 - 7.1e-09 35.3 0.0 1e-08 34.8 0.0 1.2 1 0 0 1 1 1 1 LysR substrate binding domain HTH_11 PF08279.12 CAV25589.1 - 0.053 13.5 0.2 1 9.4 0.1 2.3 1 1 1 2 2 2 0 HTH domain MarC PF01914.17 CAV25594.1 - 1.1e-42 145.7 13.4 1.4e-42 145.4 13.4 1.0 1 0 0 1 1 1 1 MarC family integral membrane protein MgtE PF01769.16 CAV25596.1 - 1.2e-20 74.2 6.8 1.2e-20 74.2 6.8 1.6 2 0 0 2 2 2 1 Divalent cation transporter MgtE_N PF03448.17 CAV25596.1 - 1.6e-09 38.2 1.7 2.8e-09 37.5 1.7 1.4 1 0 0 1 1 1 1 MgtE intracellular N domain CBS PF00571.28 CAV25596.1 - 0.0002 21.7 0.2 0.02 15.4 0.1 2.9 3 0 0 3 3 3 1 CBS domain DUF2385 PF09539.10 CAV25598.1 - 0.083 13.4 0.0 0.1 13.1 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2385) DUF4980 PF16352.5 CAV25598.1 - 0.11 12.5 0.2 0.2 11.6 0.2 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4980) SNARE_assoc PF09335.11 CAV25600.1 - 3.1e-17 63.2 4.8 3.1e-17 63.2 4.8 1.9 1 1 0 2 2 2 1 SNARE associated Golgi protein PGG PF13962.6 CAV25600.1 - 0.49 10.2 8.6 0.074 12.9 3.8 2.0 2 0 0 2 2 2 0 Domain of unknown function Herpes_UL73 PF03554.13 CAV25600.1 - 5.3 7.1 9.8 15 5.6 0.7 3.4 3 0 0 3 3 3 0 UL73 viral envelope glycoprotein Na_Ca_ex PF01699.24 CAV25601.1 - 8.4e-25 87.5 42.8 1.7e-16 60.5 18.4 2.1 2 0 0 2 2 2 2 Sodium/calcium exchanger protein SecD_SecF PF02355.16 CAV25603.1 - 2.1e-55 187.1 5.3 2.1e-55 187.1 5.3 1.9 2 0 0 2 2 2 1 Protein export membrane protein Sec_GG PF07549.14 CAV25603.1 - 4.8e-09 35.4 0.1 1.3e-08 34.0 0.1 1.8 1 0 0 1 1 1 1 SecD/SecF GG Motif DUF4131 PF13567.6 CAV25603.1 - 0.58 9.8 3.4 0.46 10.1 1.7 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) SecD_SecF PF02355.16 CAV25605.1 - 1.1e-18 67.3 1.8 1.1e-18 67.3 1.8 1.8 2 0 0 2 2 2 1 Protein export membrane protein SecD-TM1 PF13721.6 CAV25605.1 - 9.4e-16 58.2 0.8 1.7e-14 54.1 0.2 2.7 2 0 0 2 2 2 1 SecD export protein N-terminal TM region MMPL PF03176.15 CAV25605.1 - 3.3e-07 29.6 5.8 3.3e-07 29.6 5.8 2.0 2 0 0 2 2 2 1 MMPL family Sec_GG PF07549.14 CAV25605.1 - 7.9e-05 22.0 1.1 0.00021 20.7 1.1 1.8 1 0 0 1 1 1 1 SecD/SecF GG Motif ACR_tran PF00873.19 CAV25605.1 - 0.023 12.4 3.2 0.036 11.7 3.2 1.3 1 0 0 1 1 1 0 AcrB/AcrD/AcrF family POTRA_1 PF08478.10 CAV25605.1 - 0.062 13.6 0.0 1.1 9.7 0.0 2.6 3 0 0 3 3 3 0 POTRA domain, FtsQ-type Endonuclease_1 PF04231.13 CAV25608.1 - 5.3e-41 140.8 2.7 7.4e-41 140.4 2.7 1.2 1 0 0 1 1 1 1 Endonuclease I CrtC PF07143.11 CAV25610.1 - 9.8e-54 182.4 8.1 9.8e-54 182.4 8.1 1.8 2 0 0 2 2 2 1 CrtC N-terminal lipocalin domain Lipocalin_9 PF17186.4 CAV25610.1 - 5.9e-41 139.8 2.6 2.3e-40 137.9 0.2 2.4 2 0 0 2 2 2 1 Lipocalin-like domain Polyoma_coat PF00718.20 CAV25610.1 - 0.13 11.5 0.0 0.21 10.8 0.0 1.3 1 0 0 1 1 1 0 Polyomavirus coat protein MacB_PCD PF12704.7 CAV25612.1 - 7.1e-11 42.8 0.2 3.6e-07 30.7 0.0 2.6 2 0 0 2 2 2 2 MacB-like periplasmic core domain FtsX PF02687.21 CAV25612.1 - 1.1e-10 41.8 9.4 1.1e-10 41.8 9.4 5.6 5 2 1 6 6 6 2 FtsX-like permease family DUF3285 PF11688.8 CAV25612.1 - 0.2 11.6 0.9 1.2 9.1 0.9 2.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3285) ABC_tran PF00005.27 CAV25614.1 - 1.3e-31 109.9 0.0 1.7e-31 109.6 0.0 1.1 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 CAV25614.1 - 1e-08 35.3 1.8 0.00041 20.3 0.0 2.1 1 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system RsgA_GTPase PF03193.16 CAV25614.1 - 6.7e-05 22.8 0.1 0.00012 22.0 0.1 1.4 1 0 0 1 1 1 1 RsgA GTPase AAA_29 PF13555.6 CAV25614.1 - 0.00011 21.8 0.1 0.00027 20.6 0.1 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_25 PF13481.6 CAV25614.1 - 0.0012 18.4 0.1 0.059 12.9 0.0 2.3 2 0 0 2 2 2 1 AAA domain SMC_N PF02463.19 CAV25614.1 - 0.002 17.6 0.3 0.36 10.2 0.0 2.3 2 0 0 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 CAV25614.1 - 0.0021 18.4 0.3 0.0034 17.8 0.3 1.7 1 1 0 1 1 1 1 AAA ATPase domain NACHT PF05729.12 CAV25614.1 - 0.0028 17.6 1.2 0.28 11.1 0.2 2.1 2 0 0 2 2 2 1 NACHT domain AAA_22 PF13401.6 CAV25614.1 - 0.0039 17.4 0.6 0.15 12.3 0.2 2.2 2 0 0 2 2 2 1 AAA domain KAP_NTPase PF07693.14 CAV25614.1 - 0.023 14.0 0.0 0.037 13.3 0.0 1.3 1 0 0 1 1 1 0 KAP family P-loop domain AAA_18 PF13238.6 CAV25614.1 - 0.025 15.1 0.0 0.065 13.8 0.0 1.5 1 1 0 1 1 1 0 AAA domain AAA_28 PF13521.6 CAV25614.1 - 0.026 14.8 0.0 0.05 13.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain MMR_HSR1 PF01926.23 CAV25614.1 - 0.032 14.3 0.4 0.087 12.9 0.3 1.7 2 0 0 2 2 2 0 50S ribosome-binding GTPase Dynamin_N PF00350.23 CAV25614.1 - 0.033 14.2 1.0 0.091 12.8 0.5 1.9 2 1 0 2 2 2 0 Dynamin family AAA_15 PF13175.6 CAV25614.1 - 0.046 13.4 0.7 1.2 8.8 0.0 2.1 1 1 0 2 2 2 0 AAA ATPase domain AAA_23 PF13476.6 CAV25614.1 - 0.048 14.2 0.2 0.095 13.2 0.1 1.5 2 0 0 2 2 1 0 AAA domain T2SSE PF00437.20 CAV25614.1 - 0.062 12.3 0.1 0.095 11.7 0.1 1.2 1 0 0 1 1 1 0 Type II/IV secretion system protein FtsK_SpoIIIE PF01580.18 CAV25614.1 - 0.081 12.3 0.1 0.13 11.6 0.1 1.2 1 0 0 1 1 1 0 FtsK/SpoIIIE family SbcCD_C PF13558.6 CAV25614.1 - 0.091 13.0 1.7 1.4 9.2 0.0 3.1 2 2 0 2 2 2 0 Putative exonuclease SbcCD, C subunit AAA_30 PF13604.6 CAV25614.1 - 0.1 12.3 0.6 0.34 10.6 0.1 1.9 2 0 0 2 2 2 0 AAA domain NTPase_1 PF03266.15 CAV25614.1 - 0.12 12.3 0.0 0.36 10.7 0.0 1.8 2 0 0 2 2 2 0 NTPase DUF656 PF04920.12 CAV25614.1 - 0.16 11.9 0.0 0.89 9.5 0.0 1.9 2 0 0 2 2 2 0 Family of unknown function (DUF656) AAA_7 PF12775.7 CAV25614.1 - 0.17 11.4 0.0 0.29 10.7 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region Phosphonate-bd PF12974.7 CAV25616.1 - 3.8e-52 177.3 0.1 4.6e-52 177.0 0.1 1.1 1 0 0 1 1 1 1 ABC transporter, phosphonate, periplasmic substrate-binding protein NMT1 PF09084.11 CAV25616.1 - 0.025 14.5 0.0 0.071 13.0 0.0 1.7 1 1 0 1 1 1 0 NMT1/THI5 like PGM_PMM_I PF02878.16 CAV25616.1 - 0.09 12.5 0.0 0.2 11.4 0.0 1.5 1 0 0 1 1 1 0 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I EAL PF00563.20 CAV25617.1 - 1.1e-70 237.8 0.0 1.9e-70 237.1 0.0 1.4 1 0 0 1 1 1 1 EAL domain GGDEF PF00990.21 CAV25617.1 - 5.1e-40 136.9 0.0 1.3e-39 135.5 0.0 1.8 1 0 0 1 1 1 1 Diguanylate cyclase, GGDEF domain HAMP PF00672.25 CAV25617.1 - 1.7e-10 41.1 0.0 5.6e-10 39.5 0.0 1.9 1 0 0 1 1 1 1 HAMP domain CHASE8 PF17152.4 CAV25617.1 - 0.017 15.3 0.0 1.4 9.2 0.0 2.8 2 1 0 2 2 2 0 Periplasmic sensor domain YfmQ PF10787.9 CAV25617.1 - 0.075 12.8 0.1 0.19 11.5 0.1 1.6 1 0 0 1 1 1 0 Uncharacterised protein from bacillus cereus group YtxH PF12732.7 CAV25617.1 - 0.25 11.9 1.4 20 5.8 0.0 3.7 3 1 0 3 3 3 0 YtxH-like protein ADH_zinc_N_2 PF13602.6 CAV25619.1 - 6.3e-09 37.0 0.0 1.3e-08 35.9 0.0 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 CAV25619.1 - 3.1e-05 23.8 0.0 5.5e-05 23.0 0.0 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_N_2 PF16884.5 CAV25619.1 - 8.6e-05 22.4 0.0 0.00018 21.4 0.0 1.5 1 0 0 1 1 1 1 N-terminal domain of oxidoreductase ADH_zinc_N PF00107.26 CAV25619.1 - 0.00014 21.8 0.0 0.00033 20.6 0.0 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Radical_SAM PF04055.21 CAV25623.1 - 1.9e-13 51.2 0.0 2.2e-12 47.6 0.0 2.1 2 0 0 2 2 2 1 Radical SAM superfamily B12-binding PF02310.19 CAV25623.1 - 7.5e-05 22.8 0.0 0.00064 19.8 0.0 2.2 2 0 0 2 2 2 1 B12 binding domain PhyH PF05721.13 CAV25626.1 - 1.4e-12 48.3 0.0 2.1e-12 47.8 0.0 1.2 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) EamA PF00892.20 CAV25628.1 - 2.5e-11 43.9 42.8 4.4e-06 26.9 19.3 2.3 2 0 0 2 2 2 2 EamA-like transporter family TPT PF03151.16 CAV25628.1 - 0.0002 20.8 22.2 0.01 15.2 6.6 2.8 2 1 0 2 2 2 2 Triose-phosphate Transporter family MFS_1 PF07690.16 CAV25630.1 - 1.1e-07 31.1 34.6 1.1e-07 31.1 34.6 2.8 1 1 1 2 2 2 2 Major Facilitator Superfamily TMEM154 PF15102.6 CAV25630.1 - 0.16 11.8 0.1 0.6 10.0 0.0 2.0 2 0 0 2 2 2 0 TMEM154 protein family DUF4538 PF15061.6 CAV25630.1 - 2.4 7.9 8.0 0.22 11.3 0.2 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4538) DUF1214 PF06742.11 CAV25631.1 - 2e-27 95.8 0.3 5.5e-27 94.4 0.3 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF1214) DUF1254 PF06863.12 CAV25631.1 - 1.4e-10 41.4 0.3 9.1e-10 38.7 0.0 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF1254) LysR_substrate PF03466.20 CAV25635.1 - 4e-16 59.0 0.0 5.5e-16 58.6 0.0 1.1 1 0 0 1 1 1 1 LysR substrate binding domain HTH_1 PF00126.27 CAV25635.1 - 1e-15 57.4 0.0 2e-15 56.5 0.0 1.4 1 0 0 1 1 1 1 Bacterial regulatory helix-turn-helix protein, lysR family TAFH PF07531.14 CAV25635.1 - 0.032 14.3 0.0 0.11 12.6 0.0 2.1 1 1 0 1 1 1 0 NHR1 homology to TAF Fe_dep_repress PF01325.19 CAV25635.1 - 0.061 13.5 1.6 0.37 11.0 0.4 2.6 3 0 0 3 3 3 0 Iron dependent repressor, N-terminal DNA binding domain HTH_50 PF18024.1 CAV25635.1 - 0.094 12.3 0.0 0.23 11.1 0.0 1.7 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_30 PF13556.6 CAV25635.1 - 0.12 12.2 0.0 0.25 11.2 0.0 1.4 1 0 0 1 1 1 0 PucR C-terminal helix-turn-helix domain Mga PF05043.13 CAV25635.1 - 0.28 11.8 2.0 0.33 11.5 0.4 1.9 2 0 0 2 2 2 0 Mga helix-turn-helix domain Response_reg PF00072.24 CAV25637.1 - 2.3e-21 76.1 1.1 6.2e-21 74.7 0.2 2.1 2 0 0 2 2 2 1 Response regulator receiver domain HATPase_c PF02518.26 CAV25637.1 - 1.7e-15 57.5 0.0 4e-15 56.3 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 CAV25637.1 - 1.9e-06 27.8 0.6 5.4e-06 26.3 0.6 1.8 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain HATPase_c_5 PF14501.6 CAV25637.1 - 0.12 12.3 0.0 0.36 10.7 0.0 1.8 1 0 0 1 1 1 0 GHKL domain DUF5453 PF17534.2 CAV25637.1 - 1.2 9.0 6.3 0.89 9.5 0.8 2.5 2 0 0 2 2 2 0 Family of unknown function (DUF5453) DUF2842 PF11003.8 CAV25637.1 - 1.6 9.0 8.7 0.33 11.2 2.0 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF2842) AHL_synthase PF17327.2 CAV25639.1 - 4.3e-166 552.6 0.9 4.9e-166 552.4 0.9 1.0 1 0 0 1 1 1 1 Acyl homoserine lactone synthase Cystatin PF00031.21 CAV25640.1 - 3.1e-08 33.8 0.0 5.2e-08 33.1 0.0 1.4 1 0 0 1 1 1 1 Cystatin domain SQAPI PF16845.5 CAV25640.1 - 0.055 13.8 0.0 0.084 13.2 0.0 1.3 1 0 0 1 1 1 0 Aspartic acid proteinase inhibitor DUF1411 PF07199.11 CAV25640.1 - 0.062 13.0 0.1 0.067 12.8 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1411) LPAM_1 PF08139.12 CAV25640.1 - 0.4 11.3 3.8 1.3 9.7 3.8 1.9 1 1 0 1 1 1 0 Prokaryotic membrane lipoprotein lipid attachment site ICL PF00463.21 CAV25644.1 - 1.7e-49 168.7 1.2 5.3e-19 68.1 0.0 3.1 3 0 0 3 3 3 3 Isocitrate lyase family PEP_mutase PF13714.6 CAV25644.1 - 2.7e-10 40.1 0.7 7.2e-10 38.7 0.7 1.6 2 0 0 2 2 2 1 Phosphoenolpyruvate phosphomutase HTH_1 PF00126.27 CAV25646.1 - 7e-17 61.1 0.1 1.4e-16 60.2 0.1 1.5 1 0 0 1 1 1 1 Bacterial regulatory helix-turn-helix protein, lysR family LysR_substrate PF03466.20 CAV25646.1 - 1.1e-11 44.6 0.0 4e-11 42.7 0.0 1.9 1 1 0 1 1 1 1 LysR substrate binding domain HTH_30 PF13556.6 CAV25646.1 - 0.079 12.8 0.1 0.17 11.7 0.1 1.6 1 0 0 1 1 1 0 PucR C-terminal helix-turn-helix domain Malate_synthase PF01274.22 CAV25647.1 - 3.7e-169 563.4 0.1 4.2e-169 563.2 0.1 1.0 1 0 0 1 1 1 1 Malate synthase Aldedh PF00171.22 CAV25649.1 - 1.6e-167 557.7 3.1 1.9e-167 557.5 3.1 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family BCCT PF02028.17 CAV25652.1 - 9.9e-165 548.6 48.5 1.1e-164 548.5 48.5 1.0 1 0 0 1 1 1 1 BCCT, betaine/carnitine/choline family transporter DUF4235 PF14019.6 CAV25652.1 - 0.0072 16.4 0.3 0.54 10.4 0.0 2.8 2 1 0 2 2 2 1 Protein of unknown function (DUF4235) Peptidase_M14 PF00246.24 CAV25653.1 - 7.5e-07 29.2 0.0 1.3e-06 28.4 0.0 1.4 1 0 0 1 1 1 1 Zinc carboxypeptidase AstE_AspA PF04952.14 CAV25653.1 - 8.1e-07 28.4 0.0 1.2e-06 27.8 0.0 1.2 1 0 0 1 1 1 1 Succinylglutamate desuccinylase / Aspartoacylase family DUF2817 PF10994.8 CAV25653.1 - 1.9e-05 24.3 0.0 2.6e-05 23.8 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2817) GGDEF PF00990.21 CAV25654.1 - 3e-45 153.9 0.1 4.1e-45 153.4 0.1 1.2 1 0 0 1 1 1 1 Diguanylate cyclase, GGDEF domain Amidohydro_1 PF01979.20 CAV25656.1 - 1.3e-16 60.9 1.4 2.5e-16 59.9 1.4 1.3 1 1 0 1 1 1 1 Amidohydrolase family Amidohydro_2 PF04909.14 CAV25656.1 - 2.8e-05 24.1 0.0 4.7e-05 23.3 0.0 1.4 1 0 0 1 1 1 1 Amidohydrolase ComA PF02679.15 CAV25656.1 - 0.023 14.2 0.0 0.033 13.7 0.0 1.2 1 0 0 1 1 1 0 (2R)-phospho-3-sulfolactate synthase (ComA) APS-reductase_C PF12139.8 CAV25656.1 - 0.14 12.3 0.1 1.4 9.1 0.0 2.3 2 0 0 2 2 2 0 Adenosine-5'-phosphosulfate reductase beta subunit Pmp3 PF01679.17 CAV25658.1 - 1.7e-18 66.5 6.5 1.8e-18 66.5 6.5 1.0 1 0 0 1 1 1 1 Proteolipid membrane potential modulator MOSC PF03473.17 CAV25660.1 - 5.4e-30 104.1 0.0 1e-29 103.2 0.0 1.5 1 0 0 1 1 1 1 MOSC domain MOSC_N PF03476.16 CAV25660.1 - 9.9e-30 102.9 0.0 2.1e-29 101.8 0.0 1.6 1 0 0 1 1 1 1 MOSC N-terminal beta barrel domain NAD_binding_1 PF00175.21 CAV25660.1 - 1.5e-17 64.2 0.0 3.5e-17 63.0 0.0 1.7 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.24 CAV25660.1 - 9.7e-16 57.9 0.0 2.1e-15 56.9 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain Fer2 PF00111.27 CAV25660.1 - 8.1e-12 44.9 0.6 2.3e-11 43.5 0.6 1.8 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain NAD_binding_6 PF08030.12 CAV25660.1 - 0.0018 18.4 0.0 0.073 13.2 0.0 2.5 2 0 0 2 2 2 1 Ferric reductase NAD binding domain DNA_pol3_delta2 PF13177.6 CAV25660.1 - 0.11 12.2 0.1 0.21 11.3 0.1 1.4 1 0 0 1 1 1 0 DNA polymerase III, delta subunit Peptidase_M13 PF01431.21 CAV25660.1 - 0.14 11.7 0.0 0.27 10.8 0.0 1.4 1 0 0 1 1 1 0 Peptidase family M13 NAD_synthase PF02540.17 CAV25662.1 - 6e-64 215.4 0.0 7.6e-64 215.1 0.0 1.1 1 0 0 1 1 1 1 NAD synthase QueC PF06508.13 CAV25662.1 - 0.0091 15.5 0.1 0.37 10.2 0.1 2.4 2 1 0 2 2 2 2 Queuosine biosynthesis protein QueC CTP_transf_like PF01467.26 CAV25664.1 - 9.7e-08 32.3 0.0 1.4e-07 31.8 0.0 1.3 1 0 0 1 1 1 1 Cytidylyltransferase-like ATP-sulfurylase PF01747.17 CAV25664.1 - 0.065 12.7 0.0 2.3 7.6 0.0 2.0 1 1 1 2 2 2 0 ATP-sulfurylase DUF1179 PF06678.11 CAV25664.1 - 0.14 12.1 0.4 3 7.9 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1179) AraC_binding PF02311.19 CAV25667.1 - 0.014 15.3 0.0 0.018 14.9 0.0 1.3 1 0 0 1 1 1 0 AraC-like ligand binding domain Clr5 PF14420.6 CAV25667.1 - 0.12 12.6 0.0 0.23 11.7 0.0 1.5 1 0 0 1 1 1 0 Clr5 domain Acyltransferase PF01553.21 CAV25669.1 - 6.2e-11 42.1 0.0 9.8e-11 41.4 0.0 1.3 1 0 0 1 1 1 1 Acyltransferase Gas_vesicle PF00741.18 CAV25671.1 - 0.13 12.4 0.6 19 5.5 0.1 3.1 3 0 0 3 3 3 0 Gas vesicle protein SBBP PF06739.11 CAV25671.1 - 1.9 8.5 12.5 12 6.0 1.5 4.2 4 0 0 4 4 4 0 Beta-propeller repeat DUF1496 PF07383.12 CAV25672.1 - 5.5e-24 83.5 0.4 8.3e-24 82.9 0.4 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1496) DUF406 PF04175.12 CAV25674.1 - 4.1e-29 100.9 2.0 4.7e-29 100.7 2.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF406) LuxT_C PF18285.1 CAV25675.1 - 2e-32 111.6 0.2 3.5e-32 110.8 0.1 1.4 2 0 0 2 2 2 1 Tetracycline repressor LuxT C-terminal domain TetR_N PF00440.23 CAV25675.1 - 6.1e-05 22.7 0.0 0.0002 21.1 0.0 1.9 3 0 0 3 3 3 1 Bacterial regulatory proteins, tetR family HTH_11 PF08279.12 CAV25675.1 - 0.085 12.8 0.1 0.32 11.0 0.0 2.0 1 1 1 2 2 2 0 HTH domain ABC_tran PF00005.27 CAV25677.1 - 3.4e-25 89.1 0.0 5.2e-25 88.5 0.0 1.3 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 CAV25677.1 - 1.5e-11 44.2 0.3 1.6e-06 27.8 0.1 2.0 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 CAV25677.1 - 5.8e-08 32.9 0.1 3.2e-05 23.9 0.0 2.1 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 CAV25677.1 - 2.3e-05 24.0 0.1 4.2e-05 23.2 0.1 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_23 PF13476.6 CAV25677.1 - 2.7e-05 24.7 0.1 4.5e-05 24.1 0.1 1.3 1 0 0 1 1 1 1 AAA domain RsgA_GTPase PF03193.16 CAV25677.1 - 7.2e-05 22.8 0.6 0.00064 19.7 0.1 2.1 2 0 0 2 2 2 1 RsgA GTPase MMR_HSR1 PF01926.23 CAV25677.1 - 0.00011 22.3 0.1 0.0011 19.0 0.1 2.2 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_15 PF13175.6 CAV25677.1 - 0.00017 21.4 1.0 0.001 18.9 0.1 2.0 1 1 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 CAV25677.1 - 0.00088 19.6 0.9 0.0033 17.7 0.9 1.8 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 CAV25677.1 - 0.001 19.5 0.2 0.0023 18.3 0.2 1.6 1 1 0 1 1 1 1 AAA ATPase domain AAA_25 PF13481.6 CAV25677.1 - 0.0014 18.2 0.7 0.028 14.0 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA PF00004.29 CAV25677.1 - 0.0024 18.3 0.1 0.012 16.1 0.1 2.1 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_30 PF13604.6 CAV25677.1 - 0.0029 17.3 0.0 0.0051 16.5 0.0 1.6 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.6 CAV25677.1 - 0.0039 17.4 0.0 0.011 15.8 0.0 1.8 1 1 0 1 1 1 1 AAA domain AAA_28 PF13521.6 CAV25677.1 - 0.0046 17.2 0.0 0.0071 16.6 0.0 1.3 1 0 0 1 1 1 1 AAA domain Roc PF08477.13 CAV25677.1 - 0.0053 17.0 0.0 0.13 12.5 0.0 2.3 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase ABC_ATPase PF09818.9 CAV25677.1 - 0.0062 15.4 0.7 0.039 12.8 0.1 2.1 2 1 0 2 2 2 1 Predicted ATPase of the ABC class RNA_helicase PF00910.22 CAV25677.1 - 0.0071 16.7 0.0 0.017 15.5 0.0 1.7 1 0 0 1 1 1 1 RNA helicase ATPase_2 PF01637.18 CAV25677.1 - 0.0078 16.1 0.0 0.018 15.0 0.0 1.5 1 1 0 1 1 1 1 ATPase domain predominantly from Archaea AAA_27 PF13514.6 CAV25677.1 - 0.0097 15.5 0.1 0.049 13.2 0.0 2.1 3 0 0 3 3 3 1 AAA domain NACHT PF05729.12 CAV25677.1 - 0.016 15.1 0.1 0.029 14.3 0.1 1.4 1 0 0 1 1 1 0 NACHT domain AAA_14 PF13173.6 CAV25677.1 - 0.026 14.6 0.0 0.15 12.1 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_18 PF13238.6 CAV25677.1 - 0.03 14.9 0.1 0.17 12.4 0.0 2.1 2 1 0 2 2 2 0 AAA domain IstB_IS21 PF01695.17 CAV25677.1 - 0.039 13.7 0.2 0.14 11.9 0.0 1.9 2 0 0 2 2 2 0 IstB-like ATP binding protein MukB PF04310.12 CAV25677.1 - 0.045 13.6 0.0 0.099 12.4 0.0 1.5 1 0 0 1 1 1 0 MukB N-terminal TsaE PF02367.17 CAV25677.1 - 0.047 13.7 0.2 0.11 12.5 0.1 1.7 2 0 0 2 2 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE cobW PF02492.19 CAV25677.1 - 0.047 13.3 0.8 0.11 12.1 0.2 1.8 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain DUF87 PF01935.17 CAV25677.1 - 0.061 13.4 0.3 1.2 9.2 0.1 2.1 2 0 0 2 2 2 0 Helicase HerA, central domain DUF2813 PF11398.8 CAV25677.1 - 0.071 12.3 0.0 0.12 11.6 0.0 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF2813) DUF815 PF05673.13 CAV25677.1 - 0.074 12.2 0.0 0.18 10.9 0.0 1.7 2 0 0 2 2 1 0 Protein of unknown function (DUF815) Rad17 PF03215.15 CAV25677.1 - 0.088 12.7 0.0 0.14 12.1 0.0 1.3 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_13 PF13166.6 CAV25677.1 - 0.14 10.8 0.0 9.3 4.7 0.0 2.0 2 0 0 2 2 2 0 AAA domain SbcCD_C PF13558.6 CAV25677.1 - 0.18 12.0 0.0 0.37 11.1 0.0 1.5 1 0 0 1 1 1 0 Putative exonuclease SbcCD, C subunit Rad51 PF08423.11 CAV25677.1 - 0.36 10.1 1.1 6.2 6.0 0.1 2.3 2 0 0 2 2 2 0 Rad51 FecCD PF01032.18 CAV25679.1 - 5.4e-90 301.6 35.8 6.4e-90 301.3 35.8 1.0 1 0 0 1 1 1 1 FecCD transport family DUF2583 PF10762.9 CAV25679.1 - 3.8 8.0 5.9 6.1 7.3 0.0 3.5 3 1 0 3 3 3 0 Protein of unknown function (DUF2583) Peripla_BP_2 PF01497.18 CAV25681.1 - 7.6e-38 130.4 0.2 8.9e-38 130.2 0.2 1.0 1 0 0 1 1 1 1 Periplasmic binding protein Eno-Rase_NADH_b PF12242.8 CAV25681.1 - 0.094 12.5 0.4 0.35 10.6 0.4 2.0 1 0 0 1 1 1 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase ExbD PF02472.16 CAV25682.1 - 4.7e-21 75.3 0.1 5.6e-21 75.1 0.1 1.1 1 0 0 1 1 1 1 Biopolymer transport protein ExbD/TolR Polysacc_deac_1 PF01522.21 CAV25682.1 - 0.16 11.9 0.0 0.22 11.4 0.0 1.2 1 0 0 1 1 1 0 Polysaccharide deacetylase MotA_ExbB PF01618.16 CAV25684.1 - 1.3e-22 79.9 2.0 2.1e-22 79.2 1.4 1.7 1 1 1 2 2 2 1 MotA/TolQ/ExbB proton channel family TonB_C PF03544.14 CAV25686.1 - 5.9e-24 84.3 0.1 1.3e-22 80.0 0.0 2.6 2 0 0 2 2 2 1 Gram-negative bacterial TonB protein C-terminal TonB_2 PF13103.6 CAV25686.1 - 0.00029 21.0 0.0 0.0011 19.2 0.0 2.0 1 0 0 1 1 1 1 TonB C terminal Radical_SAM PF04055.21 CAV25688.1 - 1e-14 55.3 0.0 1.7e-14 54.6 0.0 1.3 1 0 0 1 1 1 1 Radical SAM superfamily ChuX_HutX PF06228.13 CAV25690.1 - 6.6e-36 123.0 0.0 7.8e-36 122.8 0.0 1.1 1 0 0 1 1 1 1 Haem utilisation ChuX/HutX HemS PF05171.12 CAV25690.1 - 1.3e-09 38.1 0.0 1.6e-09 37.8 0.0 1.1 1 0 0 1 1 1 1 Haemin-degrading HemS.ChuX domain Calsequestrin PF01216.17 CAV25690.1 - 0.098 11.7 0.1 0.38 9.7 0.0 1.8 2 0 0 2 2 2 0 Calsequestrin Putative_PNPOx PF01243.20 CAV25692.1 - 1.5e-18 66.7 0.0 2.1e-18 66.3 0.0 1.2 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Pyrid_oxidase_2 PF13883.6 CAV25692.1 - 0.00055 19.9 0.0 0.0021 18.0 0.0 1.8 1 1 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase CheW PF01584.19 CAV25694.1 - 7.1e-31 106.7 0.2 1.1e-30 106.1 0.2 1.2 1 0 0 1 1 1 1 CheW-like domain Response_reg PF00072.24 CAV25694.1 - 7e-14 51.9 0.1 1.2e-13 51.1 0.1 1.4 1 0 0 1 1 1 1 Response regulator receiver domain Rotamase_3 PF13616.6 CAV25695.1 - 2.1e-21 76.7 0.0 2.4e-21 76.5 0.0 1.1 1 0 0 1 1 1 1 PPIC-type PPIASE domain Rotamase PF00639.21 CAV25695.1 - 1.6e-19 70.7 0.1 3.2e-19 69.7 0.1 1.4 1 1 0 1 1 1 1 PPIC-type PPIASE domain Rotamase_2 PF13145.6 CAV25695.1 - 0.0002 22.2 0.0 0.00025 21.8 0.0 1.2 1 0 0 1 1 1 1 PPIC-type PPIASE domain Alpha-amylase PF00128.24 CAV25697.1 - 1.3e-18 67.7 0.1 1.7e-18 67.3 0.1 1.2 1 0 0 1 1 1 1 Alpha amylase, catalytic domain Malt_amylase_C PF16657.5 CAV25697.1 - 0.0011 19.0 0.0 0.0034 17.5 0.0 1.9 1 0 0 1 1 1 1 Maltogenic Amylase, C-terminal domain Alpha-amylase_C PF02806.18 CAV25697.1 - 0.014 15.9 0.0 0.036 14.6 0.0 1.7 1 0 0 1 1 1 0 Alpha amylase, C-terminal all-beta domain hDGE_amylase PF14701.6 CAV25697.1 - 0.022 13.9 0.0 0.039 13.1 0.0 1.3 1 0 0 1 1 1 0 Glycogen debranching enzyme, glucanotransferase domain TSNAXIP1_N PF15739.5 CAV25697.1 - 0.083 13.3 0.0 0.24 11.8 0.0 1.7 2 0 0 2 2 2 0 Translin-associated factor X-interacting N-terminus MCPsignal PF00015.21 CAV25699.1 - 5.9e-44 149.9 25.8 5.9e-44 149.9 25.8 3.5 3 1 0 3 3 3 2 Methyl-accepting chemotaxis protein (MCP) signalling domain dCache_1 PF02743.18 CAV25699.1 - 1.8e-31 109.8 0.8 1.8e-31 109.8 0.8 4.1 2 1 2 4 4 4 1 Cache domain HAMP PF00672.25 CAV25699.1 - 1.3e-11 44.7 13.4 2.7e-11 43.7 0.0 4.7 5 0 0 5 5 5 1 HAMP domain sCache_2 PF17200.4 CAV25699.1 - 0.0033 17.3 0.0 0.0033 17.3 0.0 3.9 3 2 1 4 4 4 1 Single Cache domain 2 dCache_2 PF08269.11 CAV25699.1 - 0.016 14.4 0.0 0.016 14.4 0.0 3.5 3 1 0 3 3 3 0 Cache domain Tox-HDC PF15656.6 CAV25699.1 - 0.031 14.5 1.0 0.15 12.3 0.0 2.7 3 1 0 3 3 3 0 Toxin with a H, D/N and C signature Fib_alpha PF08702.10 CAV25699.1 - 0.21 11.8 31.1 0.028 14.6 10.7 3.6 4 0 0 4 4 4 0 Fibrinogen alpha/beta chain family sCache_3_2 PF17203.4 CAV25699.1 - 0.3 11.2 0.0 0.3 11.2 0.0 3.7 2 1 1 3 3 3 0 Single cache domain 3 Lebercilin PF15619.6 CAV25699.1 - 3.5 7.2 17.0 2.2 7.9 9.9 3.0 2 1 0 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease Gate PF07670.14 CAV25700.1 - 6.5e-08 32.8 2.2 6.5e-08 32.8 2.2 3.6 3 1 0 3 3 3 3 Nucleoside recognition DUF1275 PF06912.11 CAV25702.1 - 4.7e-28 98.4 22.7 5.3e-28 98.2 22.7 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1275) GFA PF04828.14 CAV25704.1 - 8.1e-21 74.2 0.1 1.5e-20 73.3 0.1 1.4 1 0 0 1 1 1 1 Glutathione-dependent formaldehyde-activating enzyme AMPK1_CBM PF16561.5 CAV25707.1 - 3.5e-06 27.1 0.1 4.2e-06 26.9 0.1 1.1 1 0 0 1 1 1 1 Glycogen recognition site of AMP-activated protein kinase CBM_48 PF02922.18 CAV25707.1 - 0.00048 20.4 0.1 0.00061 20.1 0.1 1.1 1 0 0 1 1 1 1 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) Pollen_allerg_1 PF01357.21 CAV25707.1 - 0.0081 16.2 0.0 0.011 15.7 0.0 1.2 1 0 0 1 1 1 1 Pollen allergen Peptidase_M23 PF01551.22 CAV25709.1 - 1.6e-31 108.3 0.8 4.4e-31 106.9 0.8 1.8 1 0 0 1 1 1 1 Peptidase family M23 OapA PF04225.12 CAV25709.1 - 1.5e-05 25.0 0.3 6.1e-05 23.0 0.0 2.1 2 0 0 2 2 2 1 Opacity-associated protein A LysM-like domain EAL PF00563.20 CAV25711.1 - 1.6e-60 204.6 0.0 4.9e-60 203.0 0.0 1.8 2 0 0 2 2 2 1 EAL domain GGDEF PF00990.21 CAV25711.1 - 4.8e-27 94.7 0.2 1.2e-26 93.4 0.2 1.7 1 0 0 1 1 1 1 Diguanylate cyclase, GGDEF domain LysR_substrate PF03466.20 CAV25712.1 - 1.3e-28 99.8 0.0 1.7e-28 99.5 0.0 1.1 1 0 0 1 1 1 1 LysR substrate binding domain HTH_1 PF00126.27 CAV25712.1 - 2.6e-16 59.3 0.2 2.6e-16 59.3 0.2 2.5 4 0 0 4 4 4 1 Bacterial regulatory helix-turn-helix protein, lysR family MFS_1 PF07690.16 CAV25713.1 - 6.3e-48 163.5 64.1 3.7e-42 144.5 36.8 1.8 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 CAV25713.1 - 8.1e-11 41.1 30.1 1.3e-06 27.3 2.8 3.1 1 1 2 3 3 3 2 MFS/sugar transport protein Sugar_tr PF00083.24 CAV25713.1 - 4.4e-09 35.7 2.1 4.4e-09 35.7 2.1 3.2 1 1 1 3 3 3 1 Sugar (and other) transporter MFS_3 PF05977.13 CAV25713.1 - 3.9e-05 22.2 18.6 5.3e-05 21.8 18.6 1.3 1 0 0 1 1 1 1 Transmembrane secretion effector TRI12 PF06609.13 CAV25713.1 - 0.00014 20.4 7.7 0.00014 20.4 7.7 1.8 1 1 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) Glutaredoxin PF00462.24 CAV25718.1 - 7.3e-20 70.9 0.0 3.1e-16 59.3 0.1 2.9 3 0 0 3 3 3 2 Glutaredoxin DUF836 PF05768.14 CAV25718.1 - 0.00037 20.9 0.0 0.0058 17.0 0.0 2.2 2 0 0 2 2 2 1 Glutaredoxin-like domain (DUF836) Thioredoxin_3 PF13192.6 CAV25718.1 - 0.00098 19.1 0.8 0.6 10.2 0.0 3.4 2 1 1 3 3 3 1 Thioredoxin domain GST_N_2 PF13409.6 CAV25718.1 - 0.0048 17.2 0.0 0.024 14.9 0.0 2.0 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 CAV25718.1 - 0.0055 17.1 0.0 0.0099 16.3 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain SH3BGR PF04908.15 CAV25718.1 - 0.023 14.8 0.0 0.038 14.1 0.0 1.3 1 0 0 1 1 1 0 SH3-binding, glutamic acid-rich protein GST_N PF02798.20 CAV25718.1 - 0.1 13.0 0.1 3.9 7.9 0.0 2.9 3 0 0 3 3 3 0 Glutathione S-transferase, N-terminal domain EamA PF00892.20 CAV25720.1 - 2.4e-18 66.6 38.0 2.5e-11 43.9 13.1 2.0 2 0 0 2 2 2 2 EamA-like transporter family Porin_4 PF13609.6 CAV25722.1 - 2.6e-17 63.6 31.6 3.7e-17 63.1 31.6 1.3 1 0 0 1 1 1 1 Gram-negative porin AstE_AspA PF04952.14 CAV25724.1 - 4e-60 203.4 0.0 4.6e-60 203.2 0.0 1.0 1 0 0 1 1 1 1 Succinylglutamate desuccinylase / Aspartoacylase family Peptidase_M99 PF17033.5 CAV25724.1 - 0.00024 20.6 0.0 0.00038 20.0 0.0 1.2 1 0 0 1 1 1 1 Carboxypeptidase controlling helical cell shape catalytic Peptidase_M14 PF00246.24 CAV25724.1 - 0.021 14.6 0.0 0.16 11.8 0.0 2.3 2 1 1 3 3 3 0 Zinc carboxypeptidase PTS_EIIA_2 PF00359.22 CAV25725.1 - 2.9e-25 88.9 0.7 3.2e-25 88.7 0.7 1.0 1 0 0 1 1 1 1 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 EIIC-GAT PF03611.14 CAV25727.1 - 2.8e-134 448.2 46.5 3.3e-134 447.9 46.5 1.0 1 0 0 1 1 1 1 PTS system sugar-specific permease component PTS_IIB PF02302.17 CAV25729.1 - 5.2e-19 68.7 1.2 5.7e-19 68.6 1.2 1.0 1 0 0 1 1 1 1 PTS system, Lactose/Cellobiose specific IIB subunit Nucleos_tra2_C PF07662.13 CAV25732.1 - 1.1e-74 250.8 11.2 1.1e-74 250.8 11.2 2.3 2 1 0 2 2 2 1 Na+ dependent nucleoside transporter C-terminus Nucleos_tra2_N PF01773.20 CAV25732.1 - 7.8e-24 84.1 3.3 7.8e-24 84.1 3.3 3.6 3 0 0 3 3 3 1 Na+ dependent nucleoside transporter N-terminus Gate PF07670.14 CAV25732.1 - 2.5e-08 34.2 5.0 2.5e-08 34.2 5.0 3.1 2 1 0 2 2 2 1 Nucleoside recognition Peptidase_C34 PF05413.11 CAV25732.1 - 0.16 12.3 0.0 0.33 11.2 0.0 1.4 1 0 0 1 1 1 0 Putative closterovirus papain-like endopeptidase Methyltransf_25 PF13649.6 CAV25736.1 - 1.1e-11 45.3 0.0 1.8e-11 44.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CAV25736.1 - 1.2e-10 41.4 0.0 1.4e-10 41.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CAV25736.1 - 1.1e-09 38.8 0.0 2e-09 38.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CAV25736.1 - 4.6e-07 30.5 0.0 7.7e-07 29.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CAV25736.1 - 4.5e-06 26.6 0.0 5.8e-06 26.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 CAV25736.1 - 0.00022 20.8 0.0 0.00032 20.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain MetW PF07021.12 CAV25736.1 - 0.00065 19.3 0.0 0.00094 18.8 0.0 1.3 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW Methyltransf_2 PF00891.18 CAV25736.1 - 0.0012 18.2 0.0 0.0016 17.8 0.0 1.1 1 0 0 1 1 1 1 O-methyltransferase domain NodS PF05401.11 CAV25736.1 - 0.0042 16.7 0.0 0.0055 16.3 0.0 1.1 1 0 0 1 1 1 1 Nodulation protein S (NodS) Methyltransf_18 PF12847.7 CAV25736.1 - 0.02 14.8 0.0 0.03 14.3 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain CMAS PF02353.20 CAV25736.1 - 0.052 12.8 0.0 0.065 12.5 0.0 1.2 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Methyltransf_4 PF02390.17 CAV25736.1 - 0.12 11.8 0.0 0.51 9.8 0.0 1.9 1 1 1 2 2 2 0 Putative methyltransferase HAMP_N3 PF18575.1 CAV25736.1 - 0.19 11.3 0.0 0.39 10.3 0.0 1.4 1 0 0 1 1 1 0 HAMP N-terminal domain 3 DUF3541 PF12060.8 CAV25737.1 - 7.9e-115 382.2 11.3 1e-114 381.9 11.3 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3541) Med12 PF09497.10 CAV25737.1 - 0.07 13.4 0.4 6.9 7.1 0.0 2.8 2 1 1 3 3 3 0 Transcription mediator complex subunit Med12 GGDEF PF00990.21 CAV25739.1 - 2.7e-43 147.5 0.1 4e-43 147.0 0.1 1.2 1 0 0 1 1 1 1 Diguanylate cyclase, GGDEF domain CHASE PF03924.13 CAV25739.1 - 2.2e-15 57.1 0.0 3.6e-15 56.4 0.0 1.3 1 0 0 1 1 1 1 CHASE domain DEAD PF00270.29 CAV25741.1 - 3.5e-46 157.2 0.1 8.5e-46 155.9 0.0 1.6 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CAV25741.1 - 1.9e-29 102.3 0.0 1.7e-28 99.2 0.0 2.4 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 CAV25741.1 - 1.4e-06 28.4 0.0 2.7e-06 27.5 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 CAV25741.1 - 0.014 14.6 0.0 0.021 14.0 0.0 1.2 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase AAA_30 PF13604.6 CAV25741.1 - 0.029 14.1 0.2 0.14 11.8 0.1 2.2 2 2 0 2 2 2 0 AAA domain AAA_22 PF13401.6 CAV25741.1 - 0.66 10.2 2.6 2.3 8.5 2.0 2.2 2 1 0 2 2 2 0 AAA domain DUF3612 PF12268.8 CAV25742.1 - 1.8e-103 344.1 2.1 2.2e-103 343.7 0.6 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF3612) HTH_3 PF01381.22 CAV25742.1 - 4.6e-11 42.6 0.1 9.2e-08 32.0 0.0 3.9 3 1 0 3 3 3 1 Helix-turn-helix HTH_19 PF12844.7 CAV25742.1 - 2e-09 37.3 0.0 4.4e-07 29.8 0.0 3.4 3 1 0 3 3 3 1 Helix-turn-helix domain HTH_31 PF13560.6 CAV25742.1 - 9.6e-06 25.9 0.1 7.7e-05 23.0 0.0 2.6 4 0 0 4 4 4 1 Helix-turn-helix domain Peptidase_M78 PF06114.13 CAV25742.1 - 5.6e-05 23.1 0.0 0.00012 22.0 0.0 1.6 1 0 0 1 1 1 1 IrrE N-terminal-like domain Hom_end PF05204.14 CAV25742.1 - 0.16 12.1 0.1 0.95 9.7 0.0 2.3 3 0 0 3 3 3 0 Homing endonuclease DUF1140 PF06600.11 CAV25744.1 - 0.11 12.9 0.1 0.18 12.3 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1140) GGDEF PF00990.21 CAV25746.1 - 6.3e-41 139.8 0.0 1.3e-40 138.8 0.0 1.5 1 0 0 1 1 1 1 Diguanylate cyclase, GGDEF domain Rrn6 PF10214.9 CAV25746.1 - 0.0011 17.6 0.7 0.0013 17.3 0.7 1.1 1 0 0 1 1 1 1 RNA polymerase I-specific transcription-initiation factor DHR10 PF18595.1 CAV25746.1 - 0.0019 18.2 2.2 0.0052 16.8 2.2 1.7 1 0 0 1 1 1 1 Designed helical repeat protein 10 domain Tektin PF03148.14 CAV25746.1 - 0.016 14.0 3.5 0.019 13.7 1.0 2.0 1 1 1 2 2 2 0 Tektin family Seryl_tRNA_N PF02403.22 CAV25746.1 - 0.041 14.1 2.4 0.11 12.7 0.3 2.7 2 1 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain Mqo PF06039.15 CAV25746.1 - 0.075 11.6 0.7 1.7 7.1 0.0 2.1 2 0 0 2 2 2 0 Malate:quinone oxidoreductase (Mqo) I_LWEQ PF01608.17 CAV25746.1 - 0.15 12.3 1.8 0.39 11.0 0.9 2.1 2 1 0 2 2 2 0 I/LWEQ domain Bacillus_HBL PF05791.11 CAV25746.1 - 0.44 10.3 5.4 65 3.3 5.4 2.7 1 1 0 1 1 1 0 Bacillus haemolytic enterotoxin (HBL) Lectin_N PF03954.14 CAV25746.1 - 2.3 8.0 10.4 2.4 7.9 7.1 2.5 2 1 0 2 2 2 0 Hepatic lectin, N-terminal domain HR1 PF02185.16 CAV25746.1 - 9.6 6.4 8.3 2.8 8.1 1.1 2.9 3 0 0 3 3 3 0 Hr1 repeat CSD PF00313.22 CAV25748.1 - 2.3e-30 104.3 4.0 2.6e-30 104.1 4.0 1.0 1 0 0 1 1 1 1 'Cold-shock' DNA-binding domain OB_RNB PF08206.11 CAV25748.1 - 0.001 18.7 0.6 0.0012 18.5 0.6 1.4 1 1 0 1 1 1 1 Ribonuclease B OB domain CusF_Ec PF11604.8 CAV25748.1 - 0.0069 16.3 0.1 0.011 15.6 0.1 1.3 1 0 0 1 1 1 1 Copper binding periplasmic protein CusF S1 PF00575.23 CAV25748.1 - 0.063 13.6 0.0 0.076 13.4 0.0 1.2 1 0 0 1 1 1 0 S1 RNA binding domain Amidohydro_3 PF07969.11 CAV25749.1 - 7e-53 180.7 0.0 6.4e-52 177.6 0.0 2.2 1 1 0 1 1 1 1 Amidohydrolase family Amidohydro_1 PF01979.20 CAV25749.1 - 1.8e-12 47.2 0.0 2.4e-12 46.8 0.0 1.1 1 0 0 1 1 1 1 Amidohydrolase family Transp_cyt_pur PF02133.15 CAV25751.1 - 9.2e-12 44.5 4.9 1e-11 44.3 4.9 1.0 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin Transp_cyt_pur PF02133.15 CAV25753.1 - 8.7e-47 159.9 30.0 1.1e-46 159.6 30.0 1.1 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin Biotin_lipoyl_2 PF13533.6 CAV25756.1 - 5.1e-08 32.6 2.9 1.1e-05 25.2 0.1 3.7 4 0 0 4 4 4 2 Biotin-lipoyl like HlyD_D23 PF16576.5 CAV25756.1 - 1e-07 31.4 9.2 9.9e-06 24.9 9.2 2.4 1 1 0 1 1 1 1 Barrel-sandwich domain of CusB or HlyD membrane-fusion TRAM_2 PF18693.1 CAV25756.1 - 0.013 15.6 0.0 0.051 13.8 0.0 2.0 1 0 0 1 1 1 0 TRAM domain HlyD_3 PF13437.6 CAV25756.1 - 0.018 15.7 5.1 0.042 14.6 0.1 2.7 2 1 0 2 2 2 0 HlyD family secretion protein ADIP PF11559.8 CAV25756.1 - 0.022 14.9 4.9 0.022 14.9 4.9 2.5 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding MR_MLE_N PF02746.16 CAV25756.1 - 0.06 13.6 1.1 3.4 7.9 0.2 2.6 2 0 0 2 2 2 0 Mandelate racemase / muconate lactonizing enzyme, N-terminal domain LRS4 PF10422.9 CAV25756.1 - 0.14 11.7 8.9 0.21 11.2 8.9 1.2 1 0 0 1 1 1 0 Monopolin complex subunit LRS4 WEMBL PF05701.11 CAV25756.1 - 0.15 10.7 17.6 0.27 9.9 17.6 1.3 1 1 0 1 1 1 0 Weak chloroplast movement under blue light Flavi_glycoprot PF00869.20 CAV25756.1 - 0.16 11.2 7.1 0.45 9.7 4.0 2.6 2 1 1 3 3 3 0 Flavivirus glycoprotein, central and dimerisation domains Cortex-I_coil PF09304.10 CAV25756.1 - 0.34 11.1 5.0 0.61 10.3 5.0 1.4 1 0 0 1 1 1 0 Cortexillin I, coiled coil TPR_MLP1_2 PF07926.12 CAV25756.1 - 2.7 8.0 18.6 12 6.0 17.4 2.3 1 1 0 1 1 1 0 TPR/MLP1/MLP2-like protein DUF3302 PF11742.8 CAV25757.1 - 0.00012 22.1 9.2 0.00015 21.8 9.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3302) Otopetrin PF03189.13 CAV25757.1 - 0.043 12.6 0.0 0.048 12.5 0.0 1.1 1 0 0 1 1 1 0 Otopetrin PgaD PF13994.6 CAV25757.1 - 0.073 13.1 5.6 0.052 13.6 4.5 1.4 1 1 0 1 1 1 0 PgaD-like protein Pox_A14 PF05767.12 CAV25757.1 - 0.15 12.3 1.2 0.5 10.5 0.1 2.0 1 1 1 2 2 2 0 Poxvirus virion envelope protein A14 TRP PF06011.12 CAV25757.1 - 0.5 9.0 6.1 0.37 9.5 0.2 2.0 1 1 1 2 2 2 0 Transient receptor potential (TRP) ion channel Ni_hydr_CYTB PF01292.20 CAV25757.1 - 1.4 8.5 12.0 1.6 8.3 1.0 2.2 1 1 1 2 2 2 0 Prokaryotic cytochrome b561 Arabinose_bd PF12625.7 CAV25759.1 - 1.7e-12 47.8 0.0 2.6e-12 47.2 0.0 1.2 1 0 0 1 1 1 1 Arabinose-binding domain of AraC transcription regulator, N-term HTH_18 PF12833.7 CAV25759.1 - 1.9e-11 44.0 0.0 4.1e-11 43.0 0.0 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 CAV25759.1 - 2.3e-06 27.6 0.0 0.00016 21.7 0.0 3.0 3 0 0 3 3 3 1 Bacterial regulatory helix-turn-helix proteins, AraC family Cation_ATPase_N PF00690.26 CAV25759.1 - 0.011 15.4 0.0 7.5 6.3 0.0 3.0 3 0 0 3 3 3 0 Cation transporter/ATPase, N-terminus RE_NgoPII PF09521.10 CAV25759.1 - 0.16 11.1 0.0 0.25 10.5 0.0 1.2 1 0 0 1 1 1 0 NgoPII restriction endonuclease UT PF03253.14 CAV25761.1 - 2.5e-55 187.7 35.3 2.8e-55 187.5 35.3 1.0 1 0 0 1 1 1 1 Urea transporter Pyridox_ox_2 PF12900.7 CAV25762.1 - 1.2e-38 132.3 0.0 1.6e-38 131.9 0.0 1.2 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase FMN_bind_2 PF04299.12 CAV25762.1 - 0.017 14.9 0.0 0.034 13.9 0.0 1.4 1 1 0 1 1 1 0 Putative FMN-binding domain Aminotran_1_2 PF00155.21 CAV25764.1 - 3.3e-25 89.0 0.0 4.3e-25 88.7 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II GntR PF00392.21 CAV25764.1 - 5.6e-16 58.0 0.0 1.7e-15 56.4 0.0 1.9 1 0 0 1 1 1 1 Bacterial regulatory proteins, gntR family Aminotran_MocR PF12897.7 CAV25764.1 - 4.4e-05 22.5 0.1 9.4e-05 21.4 0.0 1.5 2 0 0 2 2 2 1 Alanine-glyoxylate amino-transferase HTH_11 PF08279.12 CAV25764.1 - 0.0029 17.5 0.0 0.013 15.4 0.1 2.1 2 0 0 2 2 2 1 HTH domain HTH_36 PF13730.6 CAV25764.1 - 0.028 14.4 0.1 0.095 12.7 0.0 2.0 2 0 0 2 2 2 0 Helix-turn-helix domain HTH_50 PF18024.1 CAV25764.1 - 0.035 13.7 0.0 0.34 10.5 0.0 2.4 2 0 0 2 2 2 0 Helix-turn-helix domain HTH_24 PF13412.6 CAV25764.1 - 0.04 13.5 0.0 0.17 11.5 0.0 2.1 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding Rrf2 PF02082.20 CAV25764.1 - 0.13 12.7 0.0 0.33 11.3 0.0 1.7 1 0 0 1 1 1 0 Transcriptional regulator Cys_Met_Meta_PP PF01053.20 CAV25764.1 - 0.14 10.7 0.0 0.21 10.1 0.0 1.2 1 0 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme AA_permease_2 PF13520.6 CAV25766.1 - 4.4e-29 101.6 41.4 7.4e-29 100.8 41.4 1.3 1 1 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 CAV25766.1 - 1.2e-24 86.8 37.1 3.7e-24 85.2 37.1 1.6 1 1 0 1 1 1 1 Amino acid permease HTH_24 PF13412.6 CAV25768.1 - 3e-15 55.5 0.5 4.4e-15 55.0 0.5 1.3 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding HTH_AsnC-type PF13404.6 CAV25768.1 - 3e-15 55.7 0.5 4.3e-15 55.2 0.5 1.2 1 0 0 1 1 1 1 AsnC-type helix-turn-helix domain AsnC_trans_reg PF01037.21 CAV25768.1 - 2.3e-12 46.7 0.0 4.3e-12 45.8 0.0 1.4 1 0 0 1 1 1 1 Lrp/AsnC ligand binding domain MarR_2 PF12802.7 CAV25768.1 - 1.1e-05 25.2 0.0 1.6e-05 24.7 0.0 1.2 1 0 0 1 1 1 1 MarR family HTH_20 PF12840.7 CAV25768.1 - 3.3e-05 23.9 0.0 5.3e-05 23.2 0.0 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain MarR PF01047.22 CAV25768.1 - 5.9e-05 22.9 0.0 9.7e-05 22.2 0.0 1.3 1 0 0 1 1 1 1 MarR family HTH_5 PF01022.20 CAV25768.1 - 0.00012 21.9 0.1 0.00021 21.1 0.1 1.3 1 0 0 1 1 1 1 Bacterial regulatory protein, arsR family HTH_11 PF08279.12 CAV25768.1 - 0.00021 21.1 0.3 0.00043 20.2 0.3 1.5 1 0 0 1 1 1 1 HTH domain HTH_IclR PF09339.10 CAV25768.1 - 0.0016 18.2 0.0 0.003 17.3 0.0 1.4 1 0 0 1 1 1 1 IclR helix-turn-helix domain HTH_Crp_2 PF13545.6 CAV25768.1 - 0.0058 16.6 0.1 0.014 15.4 0.0 1.6 2 0 0 2 2 2 1 Crp-like helix-turn-helix domain HTH_41 PF14502.6 CAV25768.1 - 0.012 15.3 0.0 0.022 14.4 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain DDRGK PF09756.9 CAV25768.1 - 0.019 14.6 0.1 0.029 14.0 0.1 1.3 1 0 0 1 1 1 0 DDRGK domain LOH1CR12 PF10158.9 CAV25768.1 - 0.033 14.2 0.3 0.19 11.8 0.1 1.9 1 1 1 2 2 2 0 Tumour suppressor protein Fe_dep_repress PF01325.19 CAV25768.1 - 0.04 14.1 0.0 0.31 11.3 0.0 2.1 2 0 0 2 2 2 0 Iron dependent repressor, N-terminal DNA binding domain HTH_WhiA PF02650.14 CAV25768.1 - 0.056 13.8 0.2 0.42 11.0 0.0 2.1 2 0 0 2 2 2 0 WhiA C-terminal HTH domain HTH_1 PF00126.27 CAV25768.1 - 0.075 13.0 0.0 0.14 12.1 0.0 1.4 1 0 0 1 1 1 0 Bacterial regulatory helix-turn-helix protein, lysR family HTH_30 PF13556.6 CAV25768.1 - 0.08 12.8 0.2 0.22 11.4 0.0 1.8 2 0 0 2 2 2 0 PucR C-terminal helix-turn-helix domain HTH_6 PF01418.17 CAV25768.1 - 0.084 12.9 0.0 0.58 10.2 0.0 2.1 2 0 0 2 2 2 0 Helix-turn-helix domain, rpiR family LysR_substrate PF03466.20 CAV25770.1 - 1.2e-20 73.8 0.0 2e-20 73.1 0.0 1.3 1 0 0 1 1 1 1 LysR substrate binding domain HTH_1 PF00126.27 CAV25770.1 - 3.9e-17 61.9 0.2 6.2e-17 61.3 0.2 1.3 1 0 0 1 1 1 1 Bacterial regulatory helix-turn-helix protein, lysR family HTH_30 PF13556.6 CAV25770.1 - 0.00026 20.7 0.6 0.00044 20.0 0.6 1.4 1 0 0 1 1 1 1 PucR C-terminal helix-turn-helix domain HTH_5 PF01022.20 CAV25770.1 - 0.0003 20.6 2.7 0.00057 19.7 2.1 1.8 2 0 0 2 2 2 1 Bacterial regulatory protein, arsR family MarR_2 PF12802.7 CAV25770.1 - 0.06 13.2 0.2 0.12 12.3 0.2 1.5 1 0 0 1 1 1 0 MarR family HTH_50 PF18024.1 CAV25770.1 - 0.17 11.5 0.2 0.41 10.3 0.2 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain LysE PF01810.18 CAV25771.1 - 4.1e-32 111.2 13.9 4.1e-32 111.2 13.9 1.3 2 0 0 2 2 2 1 LysE type translocator MarC PF01914.17 CAV25771.1 - 0.065 12.6 6.3 0.15 11.4 6.3 1.7 1 1 0 1 1 1 0 MarC family integral membrane protein Hydrolase_4 PF12146.8 CAV25773.1 - 8.9e-15 54.6 0.1 5.3e-13 48.8 0.1 2.1 1 1 0 2 2 2 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 CAV25773.1 - 8.1e-09 36.4 0.0 1.1e-08 36.0 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_2 PF02230.16 CAV25773.1 - 2.3e-05 24.3 0.0 0.16 11.7 0.0 2.9 3 0 0 3 3 3 2 Phospholipase/Carboxylesterase Thioesterase PF00975.20 CAV25773.1 - 0.0015 18.7 0.0 0.0026 17.9 0.0 1.3 1 0 0 1 1 1 1 Thioesterase domain DLH PF01738.18 CAV25773.1 - 0.0018 17.8 0.0 1.4 8.4 0.0 3.1 1 1 1 2 2 2 1 Dienelactone hydrolase family Abhydrolase_1 PF00561.20 CAV25773.1 - 0.11 12.1 0.5 0.55 9.8 0.4 2.2 1 1 1 2 2 2 0 alpha/beta hydrolase fold HlyE PF06109.13 CAV25775.1 - 0.001 18.4 0.1 0.0011 18.4 0.1 1.1 1 0 0 1 1 1 1 Haemolysin E (HlyE) DUF4190 PF13828.6 CAV25775.1 - 0.0079 15.9 0.7 0.011 15.4 0.7 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4190) Phage_holin_3_6 PF07332.11 CAV25775.1 - 0.0084 16.1 0.3 0.0098 15.9 0.3 1.1 1 0 0 1 1 1 1 Putative Actinobacterial Holin-X, holin superfamily III DUF4342 PF14242.6 CAV25775.1 - 0.05 13.6 0.4 0.073 13.1 0.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4342) Prismane PF03063.20 CAV25777.1 - 6.2e-161 536.6 0.0 7e-161 536.4 0.0 1.0 1 0 0 1 1 1 1 Prismane/CO dehydrogenase family Phage_Coat_A PF05357.13 CAV25777.1 - 0.17 11.7 0.1 0.36 10.6 0.1 1.5 1 0 0 1 1 1 0 Phage Coat Protein A Fer2 PF00111.27 CAV25779.1 - 2.9e-13 49.6 1.3 5.5e-13 48.7 1.3 1.4 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain FAD_binding_6 PF00970.24 CAV25779.1 - 1.6e-12 47.6 0.0 2.9e-12 46.8 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_1 PF00175.21 CAV25779.1 - 6.1e-11 42.9 0.0 1.1e-10 42.2 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain NAD_binding_6 PF08030.12 CAV25779.1 - 0.0096 16.1 0.4 0.08 13.1 0.0 2.2 2 1 1 3 3 3 1 Ferric reductase NAD binding domain DUF442 PF04273.13 CAV25779.1 - 0.017 15.2 0.3 0.03 14.4 0.3 1.3 1 0 0 1 1 1 0 Putative phosphatase (DUF442) DHODB_Fe-S_bind PF10418.9 CAV25779.1 - 0.038 13.8 1.4 0.1 12.4 1.4 1.7 1 0 0 1 1 1 0 Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B Nuc_deoxyrib_tr PF05014.15 CAV25779.1 - 0.098 12.7 0.0 0.19 11.7 0.0 1.5 1 0 0 1 1 1 0 Nucleoside 2-deoxyribosyltransferase FAD_binding_8 PF08022.12 CAV25779.1 - 0.16 12.1 0.0 0.36 10.9 0.0 1.5 1 0 0 1 1 1 0 FAD-binding domain STOP PF05217.12 CAV25779.1 - 0.21 11.9 4.0 0.35 11.2 2.7 2.1 2 0 0 2 2 2 0 STOP protein Gp_dh_C PF02800.20 CAV25780.1 - 9.3e-41 139.0 0.1 1.5e-40 138.3 0.1 1.4 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain Gp_dh_N PF00044.24 CAV25780.1 - 1.1e-21 77.1 0.1 3.8e-21 75.3 0.0 2.0 2 0 0 2 2 2 1 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain DUF480 PF04337.12 CAV25782.1 - 0.027 14.6 0.1 0.082 13.0 0.1 1.8 1 0 0 1 1 1 0 Protein of unknown function, DUF480 DUF1282 PF06930.12 CAV25782.1 - 0.2 11.4 1.4 1.9 8.3 0.0 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF1282) HATPase_c PF02518.26 CAV25783.1 - 2.1e-30 105.5 0.0 6.3e-30 104.0 0.0 1.8 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 CAV25783.1 - 7.2e-23 80.9 0.0 1.7e-22 79.7 0.0 1.7 1 0 0 1 1 1 1 Response regulator receiver domain HisKA PF00512.25 CAV25783.1 - 8.3e-21 73.8 1.3 3.3e-20 71.9 0.7 2.5 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain HATPase_c_2 PF13581.6 CAV25783.1 - 0.00042 20.3 0.0 0.0012 18.8 0.0 1.7 2 0 0 2 2 2 1 Histidine kinase-like ATPase domain HATPase_c_3 PF13589.6 CAV25783.1 - 0.0011 18.9 0.0 0.0027 17.5 0.0 1.8 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase SLATT_5 PF18160.1 CAV25785.1 - 0.45 9.8 2.9 0.53 9.6 2.9 1.0 1 0 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain family 5 Peptidase_M15_3 PF08291.11 CAV25787.1 - 1.6e-06 28.2 0.0 2.8e-06 27.4 0.0 1.4 1 0 0 1 1 1 1 Peptidase M15 Peptidase_M15_2 PF05951.13 CAV25787.1 - 0.13 12.0 0.0 0.34 10.6 0.0 1.8 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF882) DUF496 PF04363.12 CAV25788.1 - 8.2e-42 141.2 12.5 9.4e-42 141.0 12.5 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF496) Sec66 PF09802.9 CAV25788.1 - 0.036 13.7 0.7 0.047 13.3 0.7 1.4 1 1 0 1 1 1 0 Preprotein translocase subunit Sec66 COMPASS-Shg1 PF05205.12 CAV25788.1 - 0.23 12.2 5.5 0.29 11.9 5.5 1.1 1 0 0 1 1 1 0 COMPASS (Complex proteins associated with Set1p) component shg1 Calci_bind_CcbP PF11535.8 CAV25790.1 - 0.083 13.4 0.2 0.11 13.0 0.2 1.1 1 0 0 1 1 1 0 Calcium binding DUF480 PF04337.12 CAV25792.1 - 3e-64 215.6 0.1 9.4e-64 214.0 0.0 1.7 1 1 1 2 2 2 1 Protein of unknown function, DUF480 DUF2046 PF09755.9 CAV25792.1 - 0.0038 16.5 0.1 0.0045 16.3 0.1 1.1 1 0 0 1 1 1 1 Uncharacterized conserved protein H4 (DUF2046) HalX PF08663.10 CAV25792.1 - 0.014 15.7 0.3 0.041 14.2 0.3 1.8 1 0 0 1 1 1 0 HalX domain DivIC PF04977.15 CAV25792.1 - 0.13 12.0 0.1 0.27 11.0 0.1 1.5 1 0 0 1 1 1 0 Septum formation initiator bZIP_1 PF00170.21 CAV25792.1 - 0.14 12.3 1.0 0.33 11.1 1.0 1.6 1 0 0 1 1 1 0 bZIP transcription factor GIY-YIG PF01541.24 CAV25794.1 - 1.8e-17 63.3 0.1 2.6e-17 62.8 0.1 1.2 1 0 0 1 1 1 1 GIY-YIG catalytic domain Peripla_BP_4 PF13407.6 CAV25796.1 - 3.2e-13 49.9 0.3 8e-13 48.5 0.3 1.6 1 1 0 1 1 1 1 Periplasmic binding protein domain DUF692 PF05114.13 CAV25796.1 - 0.029 13.6 0.0 0.048 12.9 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF692) LuxQ-periplasm PF09308.10 CAV25798.1 - 1.6e-103 345.4 1.0 2.5e-103 344.7 1.0 1.3 1 0 0 1 1 1 1 LuxQ, periplasmic HATPase_c PF02518.26 CAV25798.1 - 4.2e-27 94.9 0.5 8.7e-27 93.8 0.5 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 CAV25798.1 - 5.1e-24 84.6 0.0 1.2e-23 83.4 0.0 1.7 1 0 0 1 1 1 1 Response regulator receiver domain HisKA PF00512.25 CAV25798.1 - 2e-18 66.1 0.7 8.8e-18 64.1 0.2 2.5 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain dCache_1 PF02743.18 CAV25798.1 - 0.00089 19.1 1.2 0.0016 18.2 1.2 1.4 1 0 0 1 1 1 1 Cache domain HATPase_c_2 PF13581.6 CAV25798.1 - 0.015 15.2 0.0 0.034 14.1 0.0 1.6 1 0 0 1 1 1 0 Histidine kinase-like ATPase domain HATPase_c_5 PF14501.6 CAV25798.1 - 0.016 15.1 0.1 0.058 13.3 0.1 2.0 1 0 0 1 1 1 0 GHKL domain HATPase_c_3 PF13589.6 CAV25798.1 - 0.017 14.9 0.0 0.038 13.8 0.0 1.6 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase PAS PF00989.25 CAV25798.1 - 0.098 12.7 0.1 3.4 7.7 0.0 3.4 4 0 0 4 4 4 0 PAS fold PAS_8 PF13188.7 CAV25798.1 - 0.14 12.2 0.0 0.38 10.8 0.0 1.7 1 0 0 1 1 1 0 PAS domain HopJ PF08888.11 CAV25801.1 - 1e-48 164.1 0.2 1.1e-48 163.9 0.2 1.0 1 0 0 1 1 1 1 HopJ type III effector protein DUF1289 PF06945.13 CAV25802.1 - 1.2e-15 57.0 0.7 1.2e-15 57.0 0.7 2.1 3 0 0 3 3 3 1 Protein of unknown function (DUF1289) Cys_rich_CWC PF14375.6 CAV25802.1 - 1.4e-05 25.4 13.2 1.4e-05 25.4 13.2 2.0 2 0 0 2 2 2 1 Cysteine-rich CWC HSP70 PF00012.20 CAV25804.1 - 9.8e-21 73.6 0.1 7.7e-11 40.9 0.0 3.0 3 0 0 3 3 3 3 Hsp70 protein MreB_Mbl PF06723.13 CAV25804.1 - 1.2e-07 30.9 0.6 2.2e-05 23.5 0.0 2.5 3 0 0 3 3 3 2 MreB/Mbl protein StbA PF06406.11 CAV25804.1 - 0.00024 20.5 0.5 0.21 10.8 0.0 2.3 2 0 0 2 2 2 2 StbA protein BcrAD_BadFG PF01869.20 CAV25804.1 - 0.0085 15.6 0.2 1 8.8 0.0 2.9 2 1 0 3 3 3 1 BadF/BadG/BcrA/BcrD ATPase family EutA PF06277.11 CAV25804.1 - 0.0094 14.8 0.4 0.13 11.1 0.0 2.1 2 0 0 2 2 2 1 Ethanolamine utilisation protein EutA RuvX PF03652.15 CAV25804.1 - 0.015 15.7 0.0 0.38 11.2 0.0 2.4 2 0 0 2 2 2 0 Holliday junction resolvase DDR PF08841.10 CAV25804.1 - 0.027 13.5 0.2 0.5 9.3 0.0 2.4 2 0 0 2 2 2 0 Diol dehydratase reactivase ATPase-like domain FtsA PF14450.6 CAV25804.1 - 0.029 14.8 0.2 0.43 11.0 0.0 2.7 3 0 0 3 3 3 0 Cell division protein FtsA Ppx-GppA PF02541.16 CAV25804.1 - 0.03 13.8 0.2 0.07 12.6 0.0 1.7 2 0 0 2 2 2 0 Ppx/GppA phosphatase family Hydantoinase_A PF01968.18 CAV25804.1 - 0.11 11.8 0.4 0.8 8.9 0.0 2.1 2 0 0 2 2 2 0 Hydantoinase/oxoprolinase Porin_1 PF00267.21 CAV25806.1 - 1.6e-15 57.4 17.7 2.3e-15 56.9 17.7 1.2 1 0 0 1 1 1 1 Gram-negative porin FAA_hydrolase PF01557.18 CAV25808.1 - 2.4e-30 105.8 0.0 4.8e-29 101.6 0.0 2.0 1 1 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family DUF2848 PF11010.8 CAV25808.1 - 0.011 15.3 0.0 0.047 13.3 0.0 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF2848) LysE PF01810.18 CAV25810.1 - 1.2e-28 99.9 12.1 1.4e-28 99.7 12.1 1.0 1 0 0 1 1 1 1 LysE type translocator PGM_PMM_I PF02878.16 CAV25811.1 - 6.5e-40 136.0 0.1 1.6e-39 134.8 0.1 1.7 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_II PF02879.16 CAV25811.1 - 1.5e-25 89.8 0.3 6.7e-25 87.7 0.2 2.2 2 0 0 2 2 2 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_III PF02880.16 CAV25811.1 - 4.7e-19 68.7 0.0 8.9e-19 67.8 0.0 1.4 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_IV PF00408.20 CAV25811.1 - 1.2e-11 44.6 0.0 3.7e-11 43.0 0.0 1.8 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain COX2 PF00116.20 CAV25813.1 - 1.4e-36 125.0 0.0 3e-36 124.0 0.0 1.5 1 0 0 1 1 1 1 Cytochrome C oxidase subunit II, periplasmic domain COX2_TM PF02790.15 CAV25813.1 - 1.1e-14 54.4 2.0 2.1e-14 53.4 2.0 1.5 1 0 0 1 1 1 1 Cytochrome C oxidase subunit II, transmembrane domain Cytochrome_CBB3 PF13442.6 CAV25813.1 - 1.3e-09 38.3 0.0 2.9e-09 37.1 0.0 1.6 1 0 0 1 1 1 1 Cytochrome C oxidase, cbb3-type, subunit III Cytochrom_C PF00034.21 CAV25813.1 - 7.7e-07 30.2 3.8 1.6e-05 26.0 0.5 2.9 2 1 0 2 2 2 1 Cytochrome c Na_H_antiporter PF03553.14 CAV25813.1 - 0.011 15.0 1.4 0.016 14.5 1.4 1.2 1 0 0 1 1 1 0 Na+/H+ antiporter family Voltage_CLC PF00654.20 CAV25813.1 - 0.011 15.0 0.9 0.014 14.7 0.9 1.1 1 0 0 1 1 1 0 Voltage gated chloride channel DUF4386 PF14329.6 CAV25813.1 - 0.057 13.3 0.7 0.14 12.0 0.7 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4386) DUF2569 PF10754.9 CAV25813.1 - 0.14 12.6 4.6 0.23 11.9 4.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2569) DUF898 PF05987.13 CAV25813.1 - 0.14 11.2 2.4 0.21 10.6 2.4 1.2 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF898) COX1 PF00115.20 CAV25815.1 - 4.5e-151 503.6 78.3 5.3e-151 503.3 78.3 1.0 1 0 0 1 1 1 1 Cytochrome C and Quinol oxidase polypeptide I CtaG_Cox11 PF04442.14 CAV25817.1 - 8.4e-47 159.0 0.0 1.1e-46 158.6 0.0 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase assembly protein CtaG/Cox11 COX3 PF00510.18 CAV25819.1 - 1.9e-48 165.6 25.9 1.4e-46 159.4 25.9 2.0 1 1 0 1 1 1 1 Cytochrome c oxidase subunit III SURF1 PF02104.15 CAV25820.1 - 9.8e-21 74.8 0.1 1.5e-20 74.2 0.1 1.2 1 0 0 1 1 1 1 SURF1 family DUF3611 PF12263.8 CAV25820.1 - 0.04 13.8 0.1 1.8 8.4 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3611) SCO1-SenC PF02630.14 CAV25822.1 - 0.16 11.9 0.0 0.27 11.1 0.0 1.3 1 0 0 1 1 1 0 SCO1/SenC COX15-CtaA PF02628.15 CAV25824.1 - 2.7e-84 283.0 22.6 3.1e-84 282.8 22.6 1.0 1 0 0 1 1 1 1 Cytochrome oxidase assembly protein DUF3693 PF12472.8 CAV25824.1 - 0.061 13.0 1.3 0.25 11.0 0.0 2.6 2 1 1 3 3 3 0 Phage related protein DUF2976 PF11190.8 CAV25824.1 - 0.5 10.2 0.1 0.5 10.2 0.1 3.7 3 1 1 4 4 4 0 Protein of unknown function (DUF2976) UbiA PF01040.18 CAV25826.1 - 1.6e-63 214.4 19.5 2e-63 214.0 19.5 1.1 1 0 0 1 1 1 1 UbiA prenyltransferase family Prion_bPrPp PF11587.8 CAV25826.1 - 2.5 8.0 5.7 16 5.4 0.3 3.3 3 0 0 3 3 3 0 Major prion protein bPrPp - N terminal CAAD PF14159.6 CAV25826.1 - 5.1 7.0 7.1 0.32 10.8 0.2 2.6 3 0 0 3 3 3 0 CAAD domains of cyanobacterial aminoacyl-tRNA synthetase HTH_31 PF13560.6 CAV25828.1 - 0.15 12.4 0.0 0.22 11.9 0.0 1.2 1 0 0 1 1 1 0 Helix-turn-helix domain DUF3313 PF11769.8 CAV25829.1 - 1.5e-45 155.3 0.0 1.7e-45 155.1 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3313) QSregVF_b PF12843.7 CAV25831.1 - 3.6e-31 106.8 0.4 4e-31 106.7 0.4 1.0 1 0 0 1 1 1 1 Putative quorum-sensing-regulated virulence factor TPR_MLP1_2 PF07926.12 CAV25834.1 - 0.024 14.7 3.1 0.039 14.0 3.1 1.4 1 0 0 1 1 1 0 TPR/MLP1/MLP2-like protein Type2_restr_D3 PF16902.5 CAV25834.1 - 0.11 12.4 3.6 0.32 10.9 3.2 2.0 1 1 0 1 1 1 0 Type-2 restriction enzyme D3 domain Baculo_PEP_C PF04513.12 CAV25834.1 - 0.12 12.4 9.6 0.42 10.7 5.1 2.5 1 1 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus OmpH PF03938.14 CAV25834.1 - 0.42 10.9 9.9 1.3 9.3 9.9 1.9 1 1 0 1 1 1 0 Outer membrane protein (OmpH-like) DEDD_Tnp_IS110 PF01548.17 CAV25836.1 - 7.8e-06 25.8 0.0 1e-05 25.5 0.0 1.2 1 0 0 1 1 1 1 Transposase RelE PF06296.12 CAV25840.1 - 2.9e-10 40.3 0.5 3.4e-10 40.1 0.5 1.1 1 0 0 1 1 1 1 RelE toxin of RelE / RelB toxin-antitoxin system MqsA_antitoxin PF15731.5 CAV25841.1 - 2.1e-08 34.3 0.0 2.4e-08 34.1 0.0 1.0 1 0 0 1 1 1 1 Antitoxin component of bacterial toxin-antitoxin system, MqsA HTH_19 PF12844.7 CAV25841.1 - 6.7e-05 22.8 0.0 0.00015 21.7 0.0 1.6 1 1 0 1 1 1 1 Helix-turn-helix domain HTH_3 PF01381.22 CAV25841.1 - 0.00026 21.0 0.0 0.00052 20.0 0.0 1.5 1 0 0 1 1 1 1 Helix-turn-helix HTH_31 PF13560.6 CAV25841.1 - 0.00051 20.3 0.0 0.00073 19.8 0.0 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain Pkip-1 PF06878.11 CAV25841.1 - 0.059 13.5 0.0 0.06 13.5 0.0 1.2 1 0 0 1 1 1 0 Pkip-1 protein Acp26Ab PF05777.12 CAV25841.1 - 0.11 13.2 0.1 0.15 12.7 0.1 1.3 1 0 0 1 1 1 0 Drosophila accessory gland-specific peptide 26Ab (Acp26Ab) DEDD_Tnp_IS110 PF01548.17 CAV25847.1 - 0.00018 21.4 0.0 0.00023 21.1 0.0 1.1 1 0 0 1 1 1 1 Transposase DUF1467 PF07330.12 CAV25849.1 - 0.006 16.5 0.3 0.013 15.4 0.3 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1467) Pox_A14 PF05767.12 CAV25849.1 - 0.039 14.1 0.4 0.09 12.9 0.4 1.7 1 0 0 1 1 1 0 Poxvirus virion envelope protein A14 DUF4064 PF13273.6 CAV25849.1 - 1.2 9.4 10.0 1.7 9.0 4.6 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF4064) DAHP_synth_1 PF00793.20 CAV25851.1 - 1.5e-105 352.0 0.0 1.8e-105 351.7 0.0 1.0 1 0 0 1 1 1 1 DAHP synthetase I family PGM_PMM_I PF02878.16 CAV25852.1 - 5.9e-33 113.5 0.1 1.3e-32 112.3 0.1 1.6 2 0 0 2 2 2 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_III PF02880.16 CAV25852.1 - 3.4e-23 82.0 0.0 5.4e-23 81.4 0.0 1.3 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_II PF02879.16 CAV25852.1 - 2.3e-20 73.1 0.0 1.2e-19 70.8 0.0 2.2 2 0 0 2 2 2 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_IV PF00408.20 CAV25852.1 - 2.4e-10 40.4 0.0 4.8e-10 39.5 0.0 1.5 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain NTP_transferase PF00483.23 CAV25854.1 - 1.6e-66 224.4 0.1 4.3e-66 223.0 0.0 1.7 2 0 0 2 2 2 1 Nucleotidyl transferase MannoseP_isomer PF01050.18 CAV25854.1 - 4.9e-65 218.0 5.2 9e-65 217.2 5.2 1.4 1 0 0 1 1 1 1 Mannose-6-phosphate isomerase Cupin_2 PF07883.11 CAV25854.1 - 3e-10 39.6 1.8 6.9e-10 38.5 0.5 2.4 2 0 0 2 2 2 1 Cupin domain NTP_transf_3 PF12804.7 CAV25854.1 - 8.6e-07 29.5 0.0 6.2e-06 26.6 0.0 2.3 2 1 0 2 2 2 1 MobA-like NTP transferase domain AraC_binding PF02311.19 CAV25854.1 - 0.013 15.4 0.2 0.033 14.1 0.2 1.6 1 0 0 1 1 1 0 AraC-like ligand binding domain MS_channel PF00924.18 CAV25856.1 - 2.2e-54 184.2 0.2 9e-54 182.1 0.1 1.9 2 0 0 2 2 2 1 Mechanosensitive ion channel TrkA_N PF02254.18 CAV25858.1 - 1.5e-27 96.2 0.3 2.4e-27 95.5 0.3 1.4 1 0 0 1 1 1 1 TrkA-N domain TrkA_C PF02080.21 CAV25858.1 - 1e-09 38.0 0.2 4.5e-08 32.8 0.0 2.6 3 0 0 3 3 3 1 TrkA-C domain NAD_binding_2 PF03446.15 CAV25858.1 - 7.7e-08 32.7 0.2 2.1e-07 31.3 0.1 1.7 2 0 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase UDPG_MGDP_dh_N PF03721.14 CAV25858.1 - 3.1e-05 23.6 0.2 0.00016 21.3 0.2 1.9 1 1 1 2 2 2 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain ADH_zinc_N PF00107.26 CAV25858.1 - 0.00012 22.1 0.7 0.11 12.5 0.1 2.8 2 2 1 3 3 3 2 Zinc-binding dehydrogenase CoA_binding_2 PF13380.6 CAV25858.1 - 0.00018 22.0 0.1 0.00043 20.7 0.1 1.7 2 1 0 2 2 2 1 CoA binding domain 3HCDH_N PF02737.18 CAV25858.1 - 0.00027 20.9 0.3 0.0004 20.3 0.3 1.3 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 2-Hacid_dh_C PF02826.19 CAV25858.1 - 0.00072 19.0 0.0 0.0024 17.2 0.0 1.8 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Shikimate_DH PF01488.20 CAV25858.1 - 0.00074 19.6 0.4 0.0028 17.7 0.1 2.0 3 0 0 3 3 3 1 Shikimate / quinate 5-dehydrogenase F420_oxidored PF03807.17 CAV25858.1 - 0.0013 19.2 0.1 0.0062 17.1 0.1 2.0 2 0 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent UPF0146 PF03686.13 CAV25858.1 - 0.0064 16.4 0.1 0.014 15.2 0.1 1.8 2 1 0 2 2 2 1 Uncharacterised protein family (UPF0146) NAD_binding_7 PF13241.6 CAV25858.1 - 0.022 15.2 0.2 0.046 14.2 0.2 1.5 2 0 0 2 2 1 0 Putative NAD(P)-binding AlaDh_PNT_C PF01262.21 CAV25858.1 - 0.041 13.2 0.4 0.065 12.5 0.4 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain IlvN PF07991.12 CAV25858.1 - 0.055 13.0 0.1 0.078 12.5 0.1 1.4 1 0 0 1 1 1 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain GFO_IDH_MocA PF01408.22 CAV25858.1 - 0.055 14.3 0.0 0.097 13.5 0.0 1.5 1 0 0 1 1 1 0 Oxidoreductase family, NAD-binding Rossmann fold TrkH PF02386.16 CAV25859.1 - 2.1e-54 184.9 27.7 3.8e-54 184.0 27.7 1.4 1 1 0 1 1 1 1 Cation transport protein PMSR PF01625.21 CAV25861.1 - 1.2e-55 187.9 0.7 1.2e-55 187.9 0.7 1.6 2 0 0 2 2 2 1 Peptide methionine sulfoxide reductase SelR PF01641.18 CAV25861.1 - 1.7e-45 154.0 0.0 3.3e-45 153.1 0.0 1.5 1 0 0 1 1 1 1 SelR domain OsmC PF02566.19 CAV25862.1 - 2.5e-17 63.2 0.1 2.9e-17 63.0 0.1 1.1 1 0 0 1 1 1 1 OsmC-like protein OmpA_membrane PF01389.17 CAV25864.1 - 1.3e-24 86.9 0.2 3.6e-24 85.5 0.2 1.7 1 1 0 1 1 1 1 OmpA-like transmembrane domain OmpA PF00691.20 CAV25864.1 - 5e-24 84.5 0.4 8.7e-24 83.7 0.4 1.4 1 0 0 1 1 1 1 OmpA family OMP_b-brl PF13505.6 CAV25864.1 - 6.5e-21 75.2 3.9 6.5e-21 75.2 3.9 1.5 2 0 0 2 2 2 1 Outer membrane protein beta-barrel domain HAD_2 PF13419.6 CAV25866.1 - 5.6e-08 33.1 0.0 8.7e-08 32.4 0.0 1.3 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 CAV25866.1 - 2.7e-05 24.6 0.1 5.5e-05 23.5 0.1 1.5 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 CAV25866.1 - 0.021 15.3 0.0 0.038 14.4 0.0 1.5 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase Aminotran_3 PF00202.21 CAV25867.1 - 5.1e-82 275.7 0.0 6.4e-82 275.4 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-III Aminotran_1_2 PF00155.21 CAV25867.1 - 0.0062 15.8 0.0 0.014 14.6 0.0 1.5 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.19 CAV25869.1 - 6.4e-29 101.1 0.0 8.1e-29 100.7 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-V Cys_Met_Meta_PP PF01053.20 CAV25869.1 - 2.9e-07 29.4 0.3 4e-07 28.9 0.3 1.1 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme DegT_DnrJ_EryC1 PF01041.17 CAV25869.1 - 0.019 14.3 0.3 0.03 13.6 0.3 1.2 1 0 0 1 1 1 0 DegT/DnrJ/EryC1/StrS aminotransferase family SF3a60_bindingd PF12108.8 CAV25869.1 - 0.17 11.8 1.5 0.38 10.7 1.5 1.6 1 0 0 1 1 1 0 Splicing factor SF3a60 binding domain SBP_bac_6 PF13343.6 CAV25871.1 - 3.7e-25 88.8 0.7 5.7e-25 88.1 0.7 1.3 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_11 PF13531.6 CAV25871.1 - 1.4e-11 44.6 0.1 3.7e-11 43.2 0.1 1.6 1 1 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_1 PF01547.25 CAV25871.1 - 7.5e-11 42.5 2.5 1.1e-10 41.9 2.5 1.3 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein DAO PF01266.24 CAV25872.1 - 1.6e-46 159.6 0.0 1.9e-46 159.3 0.0 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 CAV25872.1 - 1.6e-05 25.0 0.2 8.7e-05 22.7 0.1 2.3 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.14 CAV25872.1 - 1.7e-05 23.8 0.0 0.0025 16.6 0.0 2.1 2 0 0 2 2 2 2 HI0933-like protein Pyr_redox_2 PF07992.14 CAV25872.1 - 0.00022 20.6 0.1 0.03 13.6 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 CAV25872.1 - 0.00024 20.4 0.2 0.00046 19.5 0.2 1.4 1 0 0 1 1 1 1 Thi4 family Pyr_redox_3 PF13738.6 CAV25872.1 - 0.0021 17.4 0.2 0.51 9.5 0.3 2.4 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 CAV25872.1 - 0.084 11.9 0.8 0.23 10.5 0.8 1.8 1 1 0 1 1 1 0 FAD binding domain Pyr_redox PF00070.27 CAV25872.1 - 0.086 13.4 0.1 6.1 7.5 0.1 2.8 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase DUF4752 PF15944.5 CAV25872.1 - 0.11 12.6 0.0 1.3 9.1 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4752) Trp_halogenase PF04820.14 CAV25872.1 - 0.14 11.0 0.5 0.6 8.9 0.4 1.9 2 0 0 2 2 2 0 Tryptophan halogenase ABC_tran PF00005.27 CAV25874.1 - 4.5e-34 117.9 0.0 8.7e-34 117.0 0.0 1.5 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 CAV25874.1 - 2.2e-11 44.2 0.6 3.2e-05 23.9 0.1 2.2 1 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 CAV25874.1 - 2.9e-06 26.9 0.1 0.003 17.0 0.0 2.2 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain ABC_ATPase PF09818.9 CAV25874.1 - 5.6e-05 22.1 0.5 0.0043 15.9 0.1 2.7 2 1 0 2 2 2 1 Predicted ATPase of the ABC class AAA_23 PF13476.6 CAV25874.1 - 6.1e-05 23.6 0.1 0.00011 22.8 0.1 1.5 1 0 0 1 1 1 1 AAA domain TOBE_2 PF08402.10 CAV25874.1 - 0.00019 21.6 0.1 0.00068 19.7 0.0 2.0 3 0 0 3 3 1 1 TOBE domain AAA PF00004.29 CAV25874.1 - 0.00036 21.0 0.3 0.0031 17.9 0.3 2.3 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RsgA_GTPase PF03193.16 CAV25874.1 - 0.00044 20.2 0.0 0.00097 19.1 0.0 1.5 1 0 0 1 1 1 1 RsgA GTPase AAA_29 PF13555.6 CAV25874.1 - 0.0011 18.6 0.0 0.0023 17.6 0.0 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_16 PF13191.6 CAV25874.1 - 0.0019 18.6 0.1 0.0054 17.1 0.0 1.6 1 1 0 1 1 1 1 AAA ATPase domain TOBE_3 PF12857.7 CAV25874.1 - 0.0032 17.4 0.0 0.0068 16.3 0.0 1.5 1 0 0 1 1 1 1 TOBE-like domain PduV-EutP PF10662.9 CAV25874.1 - 0.0047 16.7 0.0 0.054 13.3 0.0 2.4 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation AAA_15 PF13175.6 CAV25874.1 - 0.0051 16.6 0.0 0.0081 15.9 0.0 1.3 1 0 0 1 1 1 1 AAA ATPase domain AAA_28 PF13521.6 CAV25874.1 - 0.0067 16.7 0.2 0.018 15.3 0.1 1.8 2 0 0 2 2 2 1 AAA domain TOBE PF03459.17 CAV25874.1 - 0.0084 16.4 0.0 0.02 15.1 0.0 1.6 1 0 0 1 1 1 1 TOBE domain Rad17 PF03215.15 CAV25874.1 - 0.011 15.6 0.0 0.038 13.9 0.0 1.8 2 0 0 2 2 2 0 Rad17 P-loop domain OB_MalK PF17912.1 CAV25874.1 - 0.012 16.4 0.0 0.043 14.6 0.0 2.0 1 0 0 1 1 1 0 MalK OB fold domain NACHT PF05729.12 CAV25874.1 - 0.013 15.4 0.0 0.031 14.2 0.0 1.6 1 0 0 1 1 1 0 NACHT domain AAA_5 PF07728.14 CAV25874.1 - 0.022 14.8 0.0 0.11 12.5 0.0 2.1 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_33 PF13671.6 CAV25874.1 - 0.029 14.5 0.0 0.37 11.0 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_22 PF13401.6 CAV25874.1 - 0.04 14.2 0.1 0.086 13.1 0.1 1.7 1 1 0 1 1 1 0 AAA domain IstB_IS21 PF01695.17 CAV25874.1 - 0.055 13.2 0.0 0.12 12.1 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein Mg_chelatase PF01078.21 CAV25874.1 - 0.055 12.8 0.0 0.43 9.9 0.0 2.1 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_27 PF13514.6 CAV25874.1 - 0.076 12.6 0.0 0.13 11.8 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.6 CAV25874.1 - 0.095 12.3 0.2 0.5 9.9 0.0 2.0 2 0 0 2 2 2 0 AAA domain TsaE PF02367.17 CAV25874.1 - 0.098 12.7 0.0 0.2 11.7 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE ATPase_2 PF01637.18 CAV25874.1 - 0.1 12.5 0.0 0.19 11.6 0.0 1.3 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_18 PF13238.6 CAV25874.1 - 0.12 12.9 0.0 0.22 12.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 CAV25874.1 - 0.18 12.2 0.0 0.36 11.2 0.0 1.5 1 0 0 1 1 1 0 RNA helicase BPD_transp_1 PF00528.22 CAV25876.1 - 1.2e-16 61.0 32.1 2.7e-10 40.3 11.3 4.1 2 2 2 4 4 4 2 Binding-protein-dependent transport system inner membrane component DUF1689 PF07954.11 CAV25876.1 - 0.16 12.4 0.0 3.7 7.9 0.0 3.0 3 1 0 3 3 3 0 Protein of unknown function (DUF1689) DUF4064 PF13273.6 CAV25876.1 - 7.3 6.9 32.1 7.7 6.8 4.5 5.3 2 1 3 5 5 5 0 Protein of unknown function (DUF4064) UTRA PF07702.13 CAV25878.1 - 1.8e-36 125.1 0.2 2.6e-36 124.6 0.2 1.3 1 0 0 1 1 1 1 UTRA domain GntR PF00392.21 CAV25878.1 - 4.3e-18 64.7 0.2 1.1e-17 63.4 0.1 1.8 2 0 0 2 2 2 1 Bacterial regulatory proteins, gntR family HTH_Crp_2 PF13545.6 CAV25878.1 - 0.017 15.1 0.0 0.045 13.7 0.0 1.7 1 0 0 1 1 1 0 Crp-like helix-turn-helix domain HTH_11 PF08279.12 CAV25878.1 - 0.019 14.9 0.0 0.041 13.8 0.0 1.6 1 0 0 1 1 1 0 HTH domain HTH_DeoR PF08220.12 CAV25878.1 - 0.086 12.6 0.3 1.6 8.5 0.1 2.8 3 0 0 3 3 3 0 DeoR-like helix-turn-helix domain EamA PF00892.20 CAV25880.1 - 2e-11 44.2 42.8 2.9e-06 27.5 16.8 2.6 2 1 0 2 2 2 2 EamA-like transporter family CRT-like PF08627.10 CAV25880.1 - 0.00013 21.0 7.5 0.00013 21.0 7.5 1.8 1 1 1 2 2 2 1 CRT-like, chloroquine-resistance transporter-like DUF2407_C PF13373.6 CAV25880.1 - 0.1 12.7 0.8 0.27 11.4 0.8 1.7 1 0 0 1 1 1 0 DUF2407 C-terminal domain COX14 PF14880.6 CAV25880.1 - 0.78 9.6 2.7 4.1 7.3 1.4 2.6 2 0 0 2 2 2 0 Cytochrome oxidase c assembly DctP PF03480.13 CAV25881.1 - 6.8e-48 163.4 0.0 8.6e-48 163.1 0.0 1.0 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein, family 7 DctQ PF04290.12 CAV25883.1 - 1.2e-19 70.6 7.2 1.9e-19 69.9 7.2 1.3 1 0 0 1 1 1 1 Tripartite ATP-independent periplasmic transporters, DctQ component Kelch_1 PF01344.25 CAV25883.1 - 0.0055 16.3 0.1 0.01 15.4 0.1 1.4 1 0 0 1 1 1 1 Kelch motif YrhK PF14145.6 CAV25883.1 - 0.024 14.5 0.1 0.024 14.5 0.1 1.9 2 0 0 2 2 2 0 YrhK-like protein CD20 PF04103.15 CAV25883.1 - 0.06 13.4 7.7 1 9.4 0.8 3.2 2 1 1 3 3 3 0 CD20-like family DctM PF06808.12 CAV25885.1 - 2.8e-77 260.3 44.7 3.5e-77 260.0 44.7 1.0 1 0 0 1 1 1 1 Tripartite ATP-independent periplasmic transporter, DctM component DcuC PF03606.15 CAV25885.1 - 8.9e-05 21.1 14.1 8.9e-05 21.1 14.1 2.7 2 1 1 3 3 3 2 C4-dicarboxylate anaerobic carrier SKI PF01202.22 CAV25887.1 - 2.8e-17 63.3 0.0 3.4e-17 63.0 0.0 1.1 1 0 0 1 1 1 1 Shikimate kinase AAA_33 PF13671.6 CAV25887.1 - 2.2e-05 24.6 0.0 0.00016 21.8 0.0 2.1 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.6 CAV25887.1 - 0.00013 22.5 0.0 0.0003 21.3 0.0 1.6 1 1 0 1 1 1 1 AAA domain Cytidylate_kin PF02224.18 CAV25887.1 - 0.0005 19.9 0.0 0.0033 17.2 0.0 1.9 1 1 0 2 2 2 1 Cytidylate kinase dNK PF01712.19 CAV25887.1 - 0.0019 18.1 0.0 1.4 8.7 0.0 2.2 1 1 1 2 2 2 2 Deoxynucleoside kinase AAA_24 PF13479.6 CAV25887.1 - 0.0042 16.8 0.0 0.0059 16.3 0.0 1.5 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 CAV25887.1 - 0.0069 16.8 0.0 0.0098 16.3 0.0 1.5 1 1 0 1 1 1 1 AAA ATPase domain DUF2075 PF09848.9 CAV25887.1 - 0.0072 15.6 0.4 0.068 12.4 0.0 2.0 1 1 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) AAA PF00004.29 CAV25887.1 - 0.0099 16.3 0.0 0.014 15.8 0.0 1.8 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Cytidylate_kin2 PF13189.6 CAV25887.1 - 0.039 14.1 0.1 0.23 11.6 0.0 2.1 2 1 1 3 3 3 0 Cytidylate kinase-like family AAA_17 PF13207.6 CAV25887.1 - 0.098 13.1 0.0 0.26 11.7 0.0 1.9 1 1 1 2 2 2 0 AAA domain ABC_tran PF00005.27 CAV25887.1 - 0.11 13.0 0.5 0.22 12.0 0.5 1.8 1 1 0 1 1 1 0 ABC transporter AAA_5 PF07728.14 CAV25887.1 - 0.11 12.4 0.0 0.18 11.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) APS_kinase PF01583.20 CAV25887.1 - 0.13 12.1 0.0 0.19 11.6 0.0 1.3 1 0 0 1 1 1 0 Adenylylsulphate kinase RNA_helicase PF00910.22 CAV25887.1 - 0.17 12.3 0.0 0.42 11.0 0.0 1.8 1 1 0 1 1 1 0 RNA helicase 6PGD PF00393.19 CAV25889.1 - 1.6e-122 408.4 0.2 2.1e-122 408.1 0.2 1.1 1 0 0 1 1 1 1 6-phosphogluconate dehydrogenase, C-terminal domain NAD_binding_2 PF03446.15 CAV25889.1 - 8.3e-34 117.0 0.0 1.3e-33 116.4 0.0 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase 3HCDH_N PF02737.18 CAV25889.1 - 1.5e-05 25.0 0.0 2.8e-05 24.1 0.0 1.4 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain F420_oxidored PF03807.17 CAV25889.1 - 0.003 18.1 0.0 0.0078 16.8 0.0 1.8 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent IlvN PF07991.12 CAV25889.1 - 0.013 15.1 0.3 0.033 13.8 0.0 1.8 2 0 0 2 2 2 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain UDPG_MGDP_dh_N PF03721.14 CAV25889.1 - 0.074 12.6 0.0 0.14 11.7 0.0 1.4 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain SbcCD_C PF13558.6 CAV25889.1 - 0.15 12.3 0.1 0.72 10.1 0.0 2.1 2 0 0 2 2 2 0 Putative exonuclease SbcCD, C subunit Peptidase_S51 PF03575.17 CAV25890.1 - 9.3e-49 165.9 0.0 1.1e-48 165.7 0.0 1.0 1 0 0 1 1 1 1 Peptidase family S51 SNO PF01174.19 CAV25890.1 - 0.00041 20.2 0.0 0.00062 19.7 0.0 1.3 1 0 0 1 1 1 1 SNO glutamine amidotransferase family Peripla_BP_1 PF00532.21 CAV25892.1 - 1e-24 87.4 0.6 1.4e-24 87.0 0.6 1.1 1 0 0 1 1 1 1 Periplasmic binding proteins and sugar binding domain of LacI family Peripla_BP_3 PF13377.6 CAV25892.1 - 2.4e-22 80.0 0.1 4.8e-22 79.0 0.1 1.5 1 0 0 1 1 1 1 Periplasmic binding protein-like domain LacI PF00356.21 CAV25892.1 - 2.5e-18 65.6 0.0 6.6e-18 64.2 0.0 1.8 1 0 0 1 1 1 1 Bacterial regulatory proteins, lacI family Peripla_BP_4 PF13407.6 CAV25892.1 - 4.9e-15 55.8 0.1 7.2e-15 55.3 0.1 1.3 1 0 0 1 1 1 1 Periplasmic binding protein domain Crp PF00325.20 CAV25892.1 - 0.038 13.7 0.1 0.086 12.5 0.1 1.6 1 0 0 1 1 1 0 Bacterial regulatory proteins, crp family HTH_10 PF04967.12 CAV25892.1 - 0.04 13.7 0.0 0.11 12.3 0.0 1.8 1 0 0 1 1 1 0 HTH DNA binding domain HTH_Crp_2 PF13545.6 CAV25892.1 - 0.05 13.6 0.0 0.16 12.0 0.0 1.8 1 0 0 1 1 1 0 Crp-like helix-turn-helix domain Lipid_DES PF08557.10 CAV25892.1 - 0.22 11.1 0.0 23 4.6 0.0 2.4 2 0 0 2 2 2 0 Sphingolipid Delta4-desaturase (DES) SIP PF04954.13 CAV25894.1 - 4.4e-32 111.1 0.2 6e-32 110.6 0.2 1.2 1 0 0 1 1 1 1 Siderophore-interacting protein FAD_binding_9 PF08021.11 CAV25894.1 - 3.9e-29 101.3 0.0 2.7e-28 98.6 0.0 2.2 2 1 0 2 2 2 1 Siderophore-interacting FAD-binding domain PTR2 PF00854.21 CAV25896.1 - 7.4e-16 58.0 26.4 7.4e-16 58.0 26.4 1.7 1 1 0 1 1 1 1 POT family MFS_1 PF07690.16 CAV25896.1 - 2.9e-13 49.5 58.1 3.5e-13 49.2 53.5 2.5 1 1 1 2 2 2 2 Major Facilitator Superfamily SDH_alpha PF03313.15 CAV25897.1 - 9.3e-94 313.9 4.6 1.3e-93 313.4 4.6 1.2 1 0 0 1 1 1 1 Serine dehydratase alpha chain SDH_beta PF03315.15 CAV25897.1 - 5e-53 179.6 0.2 1e-52 178.6 0.2 1.6 1 0 0 1 1 1 1 Serine dehydratase beta chain DUF218 PF02698.17 CAV25898.1 - 7e-14 52.0 0.0 9.3e-14 51.6 0.0 1.2 1 0 0 1 1 1 1 DUF218 domain DUF333 PF03891.15 CAV25900.1 - 8.4e-20 70.7 0.2 1.1e-19 70.3 0.2 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF333) Peptidase_S8_N PF16361.5 CAV25900.1 - 0.055 14.0 0.1 0.063 13.8 0.1 1.1 1 0 0 1 1 1 0 N-terminal of Subtilase family FliC PF12445.8 CAV25900.1 - 0.07 13.5 0.1 0.083 13.2 0.1 1.1 1 0 0 1 1 1 0 Flagellin protein NUDIX PF00293.28 CAV25902.1 - 4.7e-15 55.8 0.0 5.7e-15 55.5 0.0 1.1 1 0 0 1 1 1 1 NUDIX domain NUDIX_2 PF13869.6 CAV25902.1 - 0.034 13.7 0.0 0.049 13.2 0.0 1.2 1 0 0 1 1 1 0 Nucleotide hydrolase DUF4842 PF16130.5 CAV25903.1 - 1.5e-54 185.4 0.0 2.9e-54 184.5 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4842) ABC_membrane PF00664.23 CAV25908.1 - 6.8e-29 101.4 13.5 8.5e-29 101.0 13.5 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 CAV25908.1 - 7.1e-26 91.4 0.0 1.4e-25 90.4 0.0 1.5 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 CAV25908.1 - 4.9e-07 29.4 0.0 2.3e-06 27.2 0.0 1.8 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain CheR PF01739.18 CAV25908.1 - 0.00028 20.4 0.1 0.011 15.3 0.1 2.2 2 0 0 2 2 2 1 CheR methyltransferase, SAM binding domain PgaD PF13994.6 CAV25908.1 - 0.0076 16.3 1.3 0.018 15.1 0.5 2.1 2 0 0 2 2 2 1 PgaD-like protein dNK PF01712.19 CAV25908.1 - 0.019 14.8 0.0 0.044 13.6 0.0 1.6 1 0 0 1 1 1 0 Deoxynucleoside kinase AAA_16 PF13191.6 CAV25908.1 - 0.039 14.3 0.1 0.14 12.5 0.1 2.0 1 1 0 1 1 1 0 AAA ATPase domain RsgA_GTPase PF03193.16 CAV25908.1 - 0.051 13.5 0.1 0.22 11.4 0.0 2.1 2 0 0 2 2 2 0 RsgA GTPase YwcE PF17368.2 CAV25908.1 - 0.42 11.3 4.2 0.13 12.9 0.6 2.1 2 0 0 2 2 2 0 Spore morphogenesis and germination YwcE ABC_membrane PF00664.23 CAV25910.1 - 6.8e-53 180.1 13.0 6.8e-53 180.1 13.0 1.4 2 0 0 2 2 2 1 ABC transporter transmembrane region ABC_tran PF00005.27 CAV25910.1 - 5.8e-28 98.1 0.2 1.1e-27 97.2 0.2 1.5 1 0 0 1 1 1 1 ABC transporter G-alpha PF00503.20 CAV25910.1 - 0.0011 18.2 0.4 0.0019 17.4 0.2 1.5 1 1 0 1 1 1 1 G-protein alpha subunit SMC_N PF02463.19 CAV25910.1 - 0.0021 17.5 4.3 0.0098 15.3 4.3 1.8 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain Zeta_toxin PF06414.12 CAV25910.1 - 0.0058 15.9 0.1 0.016 14.5 0.0 1.8 2 0 0 2 2 2 1 Zeta toxin RsgA_GTPase PF03193.16 CAV25910.1 - 0.0058 16.6 0.2 0.016 15.1 0.1 1.8 2 0 0 2 2 2 1 RsgA GTPase DUF87 PF01935.17 CAV25910.1 - 0.0072 16.4 0.2 0.032 14.3 0.0 2.1 2 0 0 2 2 2 1 Helicase HerA, central domain AAA_22 PF13401.6 CAV25910.1 - 0.01 16.1 0.3 0.05 13.9 0.3 2.3 1 1 0 1 1 1 0 AAA domain AAA_30 PF13604.6 CAV25910.1 - 0.012 15.3 0.1 0.037 13.7 0.1 1.8 1 1 0 1 1 1 0 AAA domain AAA_29 PF13555.6 CAV25910.1 - 0.024 14.4 0.1 0.052 13.3 0.1 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_7 PF12775.7 CAV25910.1 - 0.024 14.1 0.0 0.06 12.9 0.0 1.6 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_18 PF13238.6 CAV25910.1 - 0.031 14.8 0.0 0.11 13.0 0.0 2.0 2 0 0 2 2 1 0 AAA domain cobW PF02492.19 CAV25910.1 - 0.047 13.3 0.0 0.11 12.0 0.0 1.6 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain DUF815 PF05673.13 CAV25910.1 - 0.049 12.8 0.0 0.082 12.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) NB-ARC PF00931.22 CAV25910.1 - 0.084 12.0 0.1 0.16 11.2 0.1 1.4 1 0 0 1 1 1 0 NB-ARC domain Rad17 PF03215.15 CAV25910.1 - 0.12 12.3 0.0 0.23 11.4 0.0 1.4 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_33 PF13671.6 CAV25910.1 - 0.12 12.5 0.1 3.4 7.8 0.0 2.4 2 0 0 2 2 2 0 AAA domain TPR_1 PF00515.28 CAV25912.1 - 2.8e-06 26.9 2.0 0.085 12.7 0.2 2.9 3 0 0 3 3 3 2 Tetratricopeptide repeat Alkyl_sulf_dimr PF14863.6 CAV25912.1 - 1.9e-05 25.2 0.6 3.9e-05 24.1 0.4 1.6 1 1 0 1 1 1 1 Alkyl sulfatase dimerisation TPR_2 PF07719.17 CAV25912.1 - 2.2e-05 24.2 1.9 0.075 13.2 0.3 2.9 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_9 PF13371.6 CAV25912.1 - 2.8e-05 24.2 5.9 0.00016 21.8 1.8 2.7 2 1 1 3 3 3 1 Tetratricopeptide repeat HSP90 PF00183.18 CAV25912.1 - 0.0013 17.7 2.5 0.0019 17.2 2.5 1.1 1 0 0 1 1 1 1 Hsp90 protein ANAPC3 PF12895.7 CAV25912.1 - 0.0016 18.6 0.8 0.0028 17.8 0.8 1.4 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_8 PF13181.6 CAV25912.1 - 0.0025 17.9 2.8 0.12 12.6 0.1 3.2 4 0 0 4 4 3 1 Tetratricopeptide repeat TPR_19 PF14559.6 CAV25912.1 - 0.0083 16.6 4.2 0.015 15.8 2.5 2.3 1 1 2 3 3 3 2 Tetratricopeptide repeat TPR_17 PF13431.6 CAV25912.1 - 0.013 15.8 2.3 0.16 12.4 0.1 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_14 PF13428.6 CAV25912.1 - 0.052 14.4 3.0 13 6.9 0.0 3.5 1 1 2 3 3 3 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 CAV25912.1 - 0.063 13.3 0.4 1 9.5 0.1 3.0 2 1 2 4 4 4 0 Fis1 C-terminal tetratricopeptide repeat TPR_6 PF13174.6 CAV25912.1 - 0.19 12.4 1.2 1.5 9.6 0.4 2.9 2 1 0 2 2 2 0 Tetratricopeptide repeat DUF1700 PF08006.11 CAV25912.1 - 0.36 10.3 1.9 0.75 9.3 1.9 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1700) Peptidase_M23 PF01551.22 CAV25913.1 - 9.6e-30 102.7 0.1 2.4e-29 101.4 0.1 1.7 2 0 0 2 2 2 1 Peptidase family M23 OapA PF04225.12 CAV25913.1 - 8e-06 25.9 0.4 9.7e-05 22.4 0.0 2.6 3 0 0 3 3 3 1 Opacity-associated protein A LysM-like domain RnfC_N PF13375.6 CAV25913.1 - 0.085 12.8 0.0 0.98 9.4 0.0 2.3 2 0 0 2 2 2 0 RnfC Barrel sandwich hybrid domain Biotin_lipoyl_2 PF13533.6 CAV25913.1 - 0.092 12.6 1.0 0.33 10.8 0.1 2.4 3 0 0 3 3 3 0 Biotin-lipoyl like YbjQ_1 PF01906.17 CAV25915.1 - 7.3e-39 132.6 3.3 9.2e-39 132.3 3.3 1.1 1 0 0 1 1 1 1 Putative heavy-metal-binding RecU PF03838.14 CAV25915.1 - 0.027 14.5 0.1 0.049 13.6 0.1 1.4 1 0 0 1 1 1 0 Recombination protein U LysR_substrate PF03466.20 CAV25916.1 - 4.6e-26 91.5 0.0 9.5e-26 90.5 0.0 1.5 2 0 0 2 2 2 1 LysR substrate binding domain HTH_1 PF00126.27 CAV25916.1 - 1.3e-21 76.3 0.3 6.1e-20 70.9 0.2 2.3 2 0 0 2 2 2 1 Bacterial regulatory helix-turn-helix protein, lysR family MarR_2 PF12802.7 CAV25916.1 - 0.0086 15.9 0.1 0.022 14.6 0.1 1.6 1 0 0 1 1 1 1 MarR family HTH_30 PF13556.6 CAV25916.1 - 0.014 15.2 0.0 0.16 11.8 0.0 2.3 2 0 0 2 2 2 0 PucR C-terminal helix-turn-helix domain P22_Cro PF14549.6 CAV25916.1 - 0.1 12.4 0.1 0.24 11.3 0.1 1.5 1 0 0 1 1 1 0 DNA-binding transcriptional regulator Cro EamA PF00892.20 CAV25918.1 - 8.8e-20 71.3 42.3 9.1e-14 51.8 21.2 2.6 2 1 0 2 2 2 2 EamA-like transporter family TPT PF03151.16 CAV25918.1 - 0.0023 17.3 12.7 0.0023 17.3 12.7 1.6 2 0 0 2 2 2 1 Triose-phosphate Transporter family DUF3265 PF11665.8 CAV25918.1 - 3.6 7.9 7.5 28 5.0 0.4 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF3265) HD_5 PF13487.6 CAV25919.1 - 2.4e-21 75.7 0.0 6.7e-21 74.3 0.0 1.9 1 0 0 1 1 1 1 HD domain dCache_1 PF02743.18 CAV25919.1 - 6.6e-11 42.5 0.5 6e-10 39.3 0.1 2.6 2 1 0 2 2 2 1 Cache domain HD PF01966.22 CAV25919.1 - 1.1e-09 38.6 0.0 8e-05 22.9 0.0 2.7 2 0 0 2 2 2 2 HD domain HAMP PF00672.25 CAV25919.1 - 0.01 16.2 0.0 0.043 14.2 0.0 2.2 1 0 0 1 1 1 0 HAMP domain XTBD PF11952.8 CAV25919.1 - 0.1 12.3 0.0 0.26 11.0 0.0 1.6 1 0 0 1 1 1 0 XRN-Two Binding Domain, XTBD PHP PF02811.19 CAV25921.1 - 0.00062 20.1 0.1 0.0017 18.7 0.1 1.5 1 1 0 1 1 1 1 PHP domain PHP_C PF13263.6 CAV25921.1 - 0.0037 17.0 0.0 0.034 13.9 0.0 2.2 2 0 0 2 2 2 1 PHP-associated RNase_P_p30 PF01876.16 CAV25921.1 - 0.0092 15.5 0.0 0.022 14.2 0.0 1.5 2 0 0 2 2 2 1 RNase P subunit p30 Cytochrom_B562 PF07361.11 CAV25922.1 - 9.2e-25 87.3 3.5 1.1e-24 87.1 3.5 1.0 1 0 0 1 1 1 1 Cytochrome b562 EzrA PF06160.12 CAV25922.1 - 0.0015 16.9 1.2 0.0023 16.2 1.1 1.3 1 1 0 1 1 1 1 Septation ring formation regulator, EzrA DUF2379 PF09543.10 CAV25922.1 - 0.013 15.7 0.2 0.02 15.1 0.2 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF2379) DUF4363 PF14276.6 CAV25922.1 - 0.026 14.6 0.7 0.09 12.9 0.1 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4363) YfdX PF10938.8 CAV25922.1 - 0.033 14.1 1.2 0.12 12.4 1.2 1.7 1 1 0 1 1 1 0 YfdX protein LUC7 PF03194.15 CAV25922.1 - 0.044 13.4 2.7 0.084 12.5 2.7 1.4 1 1 0 1 1 1 0 LUC7 N_terminus Ehbp PF10622.9 CAV25922.1 - 0.062 13.3 0.0 0.11 12.6 0.0 1.4 1 0 0 1 1 1 0 Energy-converting hydrogenase B subunit P (EhbP) Fibin PF15819.5 CAV25922.1 - 0.23 11.2 3.6 3 7.6 0.2 2.0 1 1 1 2 2 2 0 Fin bud initiation factor homologue PepSY_TM PF03929.16 CAV25925.1 - 6e-60 203.4 3.4 8.4e-60 202.9 3.4 1.2 1 0 0 1 1 1 1 PepSY-associated TM region Ni_hydr_CYTB PF01292.20 CAV25925.1 - 0.0016 18.1 10.3 1.4 8.5 0.4 4.0 3 1 1 4 4 4 3 Prokaryotic cytochrome b561 DUF4405 PF14358.6 CAV25925.1 - 0.003 18.1 9.2 1 10.0 0.5 3.8 3 1 0 3 3 3 2 Domain of unknown function (DUF4405) PepSY PF03413.19 CAV25925.1 - 0.004 17.7 1.8 0.65 10.6 0.1 2.7 3 0 0 3 3 3 2 Peptidase propeptide and YPEB domain PepSY_TM_like_2 PF16357.5 CAV25925.1 - 0.65 9.9 9.4 0.1 12.6 0.5 3.3 3 1 0 3 3 3 0 Putative PepSY_TM-like DUF4079 PF13301.6 CAV25925.1 - 0.88 9.7 6.3 26 5.0 0.0 3.5 3 1 0 3 3 3 0 Protein of unknown function (DUF4079) Glyoxalase PF00903.25 CAV25927.1 - 1.1e-19 70.8 0.0 1.3e-19 70.7 0.0 1.0 1 0 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_4 PF13669.6 CAV25927.1 - 3.1e-11 43.5 0.0 3.9e-11 43.2 0.0 1.1 1 0 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_3 PF13468.6 CAV25927.1 - 3.7e-05 23.9 0.0 4.4e-05 23.7 0.0 1.0 1 0 0 1 1 1 1 Glyoxalase-like domain Glyoxalase_6 PF18029.1 CAV25927.1 - 4.1e-05 24.3 0.0 4.9e-05 24.1 0.0 1.1 1 0 0 1 1 1 1 Glyoxalase-like domain Glyoxalase_2 PF12681.7 CAV25927.1 - 6e-05 23.0 0.0 0.00012 22.0 0.0 1.5 1 1 0 1 1 1 1 Glyoxalase-like domain AhpC-TSA_2 PF13911.6 CAV25927.1 - 0.026 14.7 0.0 4.5 7.4 0.0 2.2 2 0 0 2 2 2 0 AhpC/TSA antioxidant enzyme LysR_substrate PF03466.20 CAV25928.1 - 6.7e-38 130.2 0.0 9.3e-38 129.7 0.0 1.2 1 0 0 1 1 1 1 LysR substrate binding domain HTH_1 PF00126.27 CAV25928.1 - 1.7e-19 69.5 1.0 4.5e-19 68.1 0.4 2.0 2 0 0 2 2 2 1 Bacterial regulatory helix-turn-helix protein, lysR family MarR_2 PF12802.7 CAV25928.1 - 0.04 13.8 0.0 0.084 12.8 0.0 1.5 1 0 0 1 1 1 0 MarR family MarR PF01047.22 CAV25928.1 - 0.058 13.3 0.1 0.13 12.2 0.1 1.6 1 0 0 1 1 1 0 MarR family HTH_30 PF13556.6 CAV25928.1 - 0.081 12.7 0.0 0.17 11.7 0.0 1.4 1 0 0 1 1 1 0 PucR C-terminal helix-turn-helix domain HTH_8 PF02954.19 CAV25928.1 - 0.14 11.9 0.0 0.34 10.7 0.0 1.7 1 0 0 1 1 1 0 Bacterial regulatory protein, Fis family MFS_1 PF07690.16 CAV25930.1 - 1.4e-39 136.0 40.0 4.4e-36 124.5 23.7 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 CAV25930.1 - 1.6e-05 24.0 3.4 1.6e-05 24.0 3.4 2.8 2 1 0 2 2 2 1 Sugar (and other) transporter MFS_3 PF05977.13 CAV25930.1 - 0.00098 17.6 12.1 0.12 10.8 6.0 2.3 1 1 1 2 2 2 2 Transmembrane secretion effector MFS_1_like PF12832.7 CAV25930.1 - 0.54 9.0 20.3 0.023 13.6 3.5 2.4 1 1 1 2 2 2 0 MFS_1 like family Aminotran_1_2 PF00155.21 CAV25932.1 - 4.3e-73 246.6 0.0 4.9e-73 246.4 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.19 CAV25932.1 - 5.3e-05 22.3 0.0 9e-05 21.6 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class-V DegT_DnrJ_EryC1 PF01041.17 CAV25932.1 - 0.00091 18.6 0.3 0.0024 17.3 0.3 1.7 1 1 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family SHMT PF00464.19 CAV25932.1 - 0.0014 17.3 0.0 0.023 13.3 0.0 2.1 2 0 0 2 2 2 1 Serine hydroxymethyltransferase HATPase_c_5 PF14501.6 CAV25932.1 - 0.014 15.3 0.1 0.034 14.0 0.1 1.6 1 0 0 1 1 1 0 GHKL domain Beta_elim_lyase PF01212.21 CAV25932.1 - 0.053 12.8 0.3 0.1 11.8 0.3 1.6 1 1 0 1 1 1 0 Beta-eliminating lyase Peripla_BP_4 PF13407.6 CAV25932.1 - 0.055 13.0 0.2 7.6 6.0 0.1 2.9 2 2 0 2 2 2 0 Periplasmic binding protein domain OKR_DC_1 PF01276.20 CAV25932.1 - 0.075 11.8 0.0 0.15 10.8 0.0 1.5 1 1 0 1 1 1 0 Orn/Lys/Arg decarboxylase, major domain Flg_hook PF02120.16 CAV25932.1 - 0.14 12.0 1.4 0.62 10.0 0.0 2.7 4 0 0 4 4 4 0 Flagellar hook-length control protein FliK ADH_N PF08240.12 CAV25934.1 - 1.7e-30 105.1 3.3 1.8e-30 105.0 1.5 1.9 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 CAV25934.1 - 7.2e-26 90.7 0.1 1.2e-25 90.0 0.1 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 CAV25934.1 - 3.7e-09 36.4 0.2 7.3e-09 35.4 0.2 1.5 1 1 0 1 1 1 1 Glucose dehydrogenase C-terminus AlaDh_PNT_C PF01262.21 CAV25934.1 - 0.00055 19.3 0.5 0.001 18.4 0.5 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain FAD_binding_3 PF01494.19 CAV25934.1 - 0.00076 18.8 0.3 0.0013 18.0 0.3 1.4 1 0 0 1 1 1 1 FAD binding domain ADH_zinc_N_2 PF13602.6 CAV25934.1 - 0.0011 20.0 0.0 0.0023 19.0 0.0 1.6 1 1 1 2 2 2 1 Zinc-binding dehydrogenase HI0933_like PF03486.14 CAV25934.1 - 0.0095 14.7 0.2 0.014 14.2 0.2 1.2 1 0 0 1 1 1 1 HI0933-like protein Pyr_redox_3 PF13738.6 CAV25934.1 - 0.012 14.9 0.3 0.017 14.4 0.3 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase UDPG_MGDP_dh_N PF03721.14 CAV25934.1 - 0.02 14.5 0.1 0.02 14.5 0.1 1.8 2 0 0 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Pyr_redox_2 PF07992.14 CAV25934.1 - 0.02 14.1 0.0 0.029 13.6 0.0 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 CAV25934.1 - 0.021 13.9 0.1 0.028 13.5 0.1 1.1 1 0 0 1 1 1 0 FAD binding domain FAD_oxidored PF12831.7 CAV25934.1 - 0.028 13.8 1.1 0.039 13.3 1.1 1.2 1 0 0 1 1 1 0 FAD dependent oxidoreductase FMN_dh PF01070.18 CAV25934.1 - 0.067 12.2 0.3 0.099 11.7 0.3 1.2 1 0 0 1 1 1 0 FMN-dependent dehydrogenase 2-Hacid_dh_C PF02826.19 CAV25934.1 - 0.08 12.3 0.1 0.14 11.5 0.1 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Methyltransf_25 PF13649.6 CAV25934.1 - 0.082 13.6 0.0 0.16 12.7 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Pyr_redox PF00070.27 CAV25934.1 - 0.12 12.9 1.6 0.18 12.4 0.3 2.0 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase MTS PF05175.14 CAV25934.1 - 0.16 11.5 0.1 0.25 10.9 0.1 1.2 1 0 0 1 1 1 0 Methyltransferase small domain DUF819 PF05684.12 CAV25935.1 - 8.3e-98 327.9 26.7 9.3e-98 327.7 26.7 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF819) Na_H_Exchanger PF00999.21 CAV25939.1 - 2.8e-58 197.5 50.1 3.9e-58 197.1 50.1 1.1 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family TrkA_N PF02254.18 CAV25939.1 - 1.4e-23 83.4 0.6 2.7e-23 82.4 0.6 1.5 1 0 0 1 1 1 1 TrkA-N domain Flavodoxin_2 PF02525.17 CAV25940.1 - 6.8e-44 150.0 0.0 8.7e-44 149.6 0.0 1.1 1 0 0 1 1 1 1 Flavodoxin-like fold FMN_red PF03358.15 CAV25940.1 - 2.8e-05 23.9 0.0 4.5e-05 23.2 0.0 1.4 1 1 0 1 1 1 1 NADPH-dependent FMN reductase Beta_elim_lyase PF01212.21 CAV25942.1 - 2.2e-32 112.5 0.0 3.2e-32 112.0 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase DegT_DnrJ_EryC1 PF01041.17 CAV25942.1 - 0.0039 16.6 0.0 0.18 11.0 0.0 2.2 2 0 0 2 2 2 2 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_1_2 PF00155.21 CAV25942.1 - 0.094 11.9 0.0 0.95 8.6 0.0 2.1 2 1 0 2 2 2 0 Aminotransferase class I and II YccF PF03733.13 CAV25944.1 - 7.2e-34 116.3 36.3 1.5e-18 67.3 9.6 2.1 2 0 0 2 2 2 2 Inner membrane component domain DUF3930 PF13067.6 CAV25944.1 - 0.00085 19.5 5.5 0.027 14.7 0.2 2.5 2 1 0 2 2 2 2 Protein of unknown function (DUF3930) Adipogenin PF15202.6 CAV25946.1 - 0.026 14.5 0.0 0.067 13.2 0.0 1.7 1 0 0 1 1 1 0 Adipogenin Fe-ADH PF00465.19 CAV25947.1 - 1.3e-126 422.3 7.0 1.5e-126 422.1 7.0 1.0 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase Fe-ADH_2 PF13685.6 CAV25947.1 - 9.6e-22 77.9 7.5 5.1e-19 69.0 7.5 2.3 1 1 0 1 1 1 1 Iron-containing alcohol dehydrogenase DUF4675 PF15720.5 CAV25949.1 - 0.043 13.6 0.4 0.043 13.6 0.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4675) HAD_2 PF13419.6 CAV25951.1 - 2e-22 80.1 0.0 2.7e-22 79.7 0.0 1.3 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 CAV25951.1 - 3.3e-16 60.2 0.1 2.6e-15 57.3 0.1 2.0 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 CAV25951.1 - 7.3e-12 45.2 0.0 1.3e-11 44.4 0.0 1.4 1 0 0 1 1 1 1 HAD-hyrolase-like HAD PF12710.7 CAV25951.1 - 5.8e-05 23.6 0.1 7.3e-05 23.2 0.1 1.1 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase EamA PF00892.20 CAV25952.1 - 2.7e-15 56.7 36.7 8.2e-08 32.5 16.9 2.1 2 0 0 2 2 2 2 EamA-like transporter family DUF1600 PF07667.11 CAV25952.1 - 0.028 14.6 1.6 0.12 12.6 1.5 2.2 1 1 0 1 1 1 0 Protein of unknown function (DUF1600) GGDEF PF00990.21 CAV25954.1 - 8.3e-32 110.2 0.2 5.9e-31 107.4 0.1 2.5 3 0 0 3 3 3 1 Diguanylate cyclase, GGDEF domain TPR_12 PF13424.6 CAV25954.1 - 6.2e-12 45.6 5.8 0.00094 19.4 0.1 5.2 3 2 2 5 5 5 3 Tetratricopeptide repeat TPR_2 PF07719.17 CAV25954.1 - 1.7e-11 43.3 3.3 0.45 10.7 0.2 5.7 5 0 0 5 5 5 4 Tetratricopeptide repeat GAF_2 PF13185.6 CAV25954.1 - 4e-10 40.1 0.0 7.1e-10 39.3 0.0 1.4 1 0 0 1 1 1 1 GAF domain TPR_1 PF00515.28 CAV25954.1 - 3.8e-08 32.8 5.8 0.052 13.4 0.7 5.3 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_10 PF13374.6 CAV25954.1 - 9.7e-06 25.3 0.9 3.3 7.7 0.0 4.7 3 1 1 4 4 4 2 Tetratricopeptide repeat GAF_3 PF13492.6 CAV25954.1 - 1.5e-05 25.3 0.0 0.0001 22.6 0.0 2.4 2 1 0 2 2 2 1 GAF domain TPR_8 PF13181.6 CAV25954.1 - 7.9e-05 22.6 9.1 0.17 12.1 0.6 6.0 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_MalT PF17874.1 CAV25954.1 - 0.002 17.5 0.1 0.0065 15.9 0.1 1.9 1 1 0 1 1 1 1 MalT-like TPR region TPR_7 PF13176.6 CAV25954.1 - 0.033 14.2 1.7 6.5 7.0 0.1 4.6 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_11 PF13414.6 CAV25954.1 - 0.034 13.8 0.1 8.5 6.2 0.0 3.9 4 0 0 4 4 4 0 TPR repeat Fis1_TPR_C PF14853.6 CAV25954.1 - 0.13 12.3 0.7 4.8 7.3 0.2 3.1 2 0 0 2 2 2 0 Fis1 C-terminal tetratricopeptide repeat Cation_efflux PF01545.21 CAV25956.1 - 1.5e-37 129.3 14.9 1.7e-37 129.1 14.9 1.0 1 0 0 1 1 1 1 Cation efflux family DUF5531 PF17671.1 CAV25956.1 - 0.022 14.7 1.6 0.023 14.6 0.0 1.8 2 0 0 2 2 2 0 Family of unknown function (DUF5531) UPF0114 PF03350.16 CAV25956.1 - 1.6 8.9 7.1 0.19 11.9 2.2 2.0 2 0 0 2 2 2 0 Uncharacterized protein family, UPF0114 FANCM-MHF_bd PF16783.5 CAV25957.1 - 0.073 13.2 0.6 0.36 10.9 0.4 1.9 2 0 0 2 2 2 0 FANCM to MHF binding domain HTH_1 PF00126.27 CAV25959.1 - 7.2e-16 57.9 0.1 1.2e-15 57.2 0.1 1.4 1 0 0 1 1 1 1 Bacterial regulatory helix-turn-helix protein, lysR family LysR_substrate PF03466.20 CAV25959.1 - 1.7e-13 50.5 0.0 5.7e-13 48.7 0.0 1.7 1 1 0 1 1 1 1 LysR substrate binding domain Methyltransf_23 PF13489.6 CAV25961.1 - 1.1e-13 51.4 0.0 1.6e-13 50.8 0.0 1.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CAV25961.1 - 1.7e-13 51.2 0.0 2.7e-13 50.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CAV25961.1 - 1.9e-12 47.7 0.0 3.3e-12 46.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CAV25961.1 - 1.5e-11 44.9 0.0 2.5e-11 44.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CAV25961.1 - 2.4e-10 40.4 0.0 3.2e-10 40.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain DREV PF05219.12 CAV25961.1 - 7.2e-07 28.6 0.0 7.3e-06 25.3 0.0 2.1 2 0 0 2 2 2 1 DREV methyltransferase PrmA PF06325.13 CAV25961.1 - 2.2e-06 27.3 0.0 3e-06 26.9 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) NodS PF05401.11 CAV25961.1 - 6.9e-05 22.6 0.0 9.3e-05 22.1 0.0 1.1 1 0 0 1 1 1 1 Nodulation protein S (NodS) MTS PF05175.14 CAV25961.1 - 0.0001 21.9 0.0 0.00015 21.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain Ubie_methyltran PF01209.18 CAV25961.1 - 0.00061 19.2 0.0 0.0012 18.2 0.0 1.4 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family TehB PF03848.14 CAV25961.1 - 0.0018 17.7 0.0 0.0033 16.9 0.0 1.4 1 0 0 1 1 1 1 Tellurite resistance protein TehB RrnaAD PF00398.20 CAV25961.1 - 0.0026 16.9 0.0 0.0033 16.5 0.0 1.2 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase CMAS PF02353.20 CAV25961.1 - 0.0064 15.8 0.0 0.0084 15.4 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_32 PF13679.6 CAV25961.1 - 0.014 15.3 0.0 0.022 14.8 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_16 PF10294.9 CAV25961.1 - 0.022 14.5 0.0 0.034 13.9 0.0 1.3 1 0 0 1 1 1 0 Lysine methyltransferase Methyltransf_18 PF12847.7 CAV25961.1 - 0.063 13.2 0.0 0.098 12.6 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain TPMT PF05724.11 CAV25961.1 - 0.077 12.6 0.0 0.13 11.8 0.0 1.4 1 0 0 1 1 1 0 Thiopurine S-methyltransferase (TPMT) MetW PF07021.12 CAV25961.1 - 0.095 12.3 0.0 0.15 11.6 0.0 1.4 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW FtsJ PF01728.19 CAV25961.1 - 0.16 12.1 0.0 0.22 11.6 0.0 1.3 1 0 0 1 1 1 0 FtsJ-like methyltransferase DUF3029 PF11230.8 CAV25963.1 - 3.4e-232 771.0 0.0 3.9e-232 770.9 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3029) NRDD PF13597.6 CAV25963.1 - 3.5e-06 26.1 0.0 4.8e-05 22.4 0.0 2.1 2 0 0 2 2 2 1 Anaerobic ribonucleoside-triphosphate reductase Radical_SAM PF04055.21 CAV25965.1 - 1e-19 71.5 0.1 1.6e-19 70.9 0.1 1.3 1 0 0 1 1 1 1 Radical SAM superfamily Fer4_12 PF13353.6 CAV25965.1 - 3.5e-11 43.5 5.8 3.4e-10 40.3 5.8 2.1 1 1 0 1 1 1 1 4Fe-4S single cluster domain Fer4_7 PF12838.7 CAV25965.1 - 7.9e-06 26.4 9.4 7.9e-06 26.4 9.4 2.1 2 0 0 2 2 1 1 4Fe-4S dicluster domain Fer4_10 PF13237.6 CAV25965.1 - 8.8e-06 25.7 10.0 8.8e-06 25.7 10.0 2.2 1 1 0 2 2 2 1 4Fe-4S dicluster domain Fer4_9 PF13187.6 CAV25965.1 - 0.00011 22.3 11.6 0.00011 22.3 11.6 2.6 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_16 PF13484.6 CAV25965.1 - 0.00023 22.0 8.5 0.014 16.3 0.4 2.7 2 0 0 2 2 2 2 4Fe-4S double cluster binding domain Fer4_6 PF12837.7 CAV25965.1 - 0.00045 20.2 13.5 0.0058 16.6 2.5 2.7 3 0 0 3 3 2 2 4Fe-4S binding domain Fer4 PF00037.27 CAV25965.1 - 0.00047 19.9 18.7 0.0068 16.2 3.2 2.7 3 0 0 3 3 2 2 4Fe-4S binding domain Fer4_4 PF12800.7 CAV25965.1 - 0.0014 18.9 21.3 0.025 15.1 3.3 3.3 3 0 0 3 3 3 2 4Fe-4S binding domain Fer4_14 PF13394.6 CAV25965.1 - 0.039 14.1 8.6 15 5.7 8.6 2.4 1 1 0 1 1 1 0 4Fe-4S single cluster domain Fer4_8 PF13183.6 CAV25965.1 - 0.062 13.7 14.1 2.2 8.8 0.2 2.7 2 1 0 2 2 2 0 4Fe-4S dicluster domain Fer4_2 PF12797.7 CAV25965.1 - 0.12 12.6 24.3 0.063 13.4 4.6 2.9 3 0 0 3 3 2 0 4Fe-4S binding domain Fer4_17 PF13534.6 CAV25965.1 - 0.24 12.0 17.3 2.7 8.6 9.0 2.8 2 1 0 2 2 2 0 4Fe-4S dicluster domain Fer4_18 PF13746.6 CAV25965.1 - 1.9 8.7 15.9 0.62 10.3 11.5 2.1 1 1 1 2 2 2 0 4Fe-4S dicluster domain Fer4_21 PF14697.6 CAV25965.1 - 4.1 7.6 19.6 0.28 11.4 12.3 2.7 1 1 2 3 3 3 0 4Fe-4S dicluster domain Fer4_3 PF12798.7 CAV25965.1 - 8.3 7.6 26.7 0.25 12.4 5.6 3.1 3 0 0 3 3 2 0 4Fe-4S binding domain LysR_substrate PF03466.20 CAV25966.1 - 7.7e-13 48.3 0.0 9.6e-13 48.0 0.0 1.1 1 0 0 1 1 1 1 LysR substrate binding domain HTH_1 PF00126.27 CAV25966.1 - 3.2e-11 43.0 0.0 6.3e-11 42.1 0.0 1.5 1 0 0 1 1 1 1 Bacterial regulatory helix-turn-helix protein, lysR family Fe_dep_repress PF01325.19 CAV25966.1 - 0.00097 19.3 1.4 0.0082 16.3 0.2 2.3 2 0 0 2 2 2 1 Iron dependent repressor, N-terminal DNA binding domain HTH_30 PF13556.6 CAV25966.1 - 0.015 15.1 0.0 0.026 14.3 0.0 1.5 1 0 0 1 1 1 0 PucR C-terminal helix-turn-helix domain HTH_5 PF01022.20 CAV25966.1 - 0.021 14.7 0.6 0.12 12.2 0.3 2.4 2 0 0 2 2 2 0 Bacterial regulatory protein, arsR family DUF155 PF02582.14 CAV25966.1 - 0.15 12.1 0.2 0.25 11.4 0.2 1.5 1 1 0 1 1 1 0 Uncharacterised ACR, YagE family COG1723 HMG-CoA_red PF00368.18 CAV25968.1 - 1.2e-110 370.0 2.7 1.4e-110 369.8 2.7 1.0 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A reductase DUF2536 PF10750.9 CAV25971.1 - 0.04 13.8 0.8 0.043 13.7 0.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2536) FUSC-like PF12805.7 CAV25973.1 - 2.6e-110 368.0 2.6 2.6e-110 368.0 2.6 1.9 2 0 0 2 2 2 1 FUSC-like inner membrane protein yccS FUSC_2 PF13515.6 CAV25973.1 - 8.4e-23 80.9 10.1 8.4e-23 80.9 10.1 2.9 2 1 1 3 3 3 1 Fusaric acid resistance protein-like FUSC PF04632.12 CAV25973.1 - 7e-14 51.3 0.2 7e-14 51.3 0.2 2.9 3 0 0 3 3 3 1 Fusaric acid resistance protein family Med8 PF10232.9 CAV25973.1 - 0.061 12.9 2.4 0.11 12.0 1.4 1.8 2 0 0 2 2 2 0 Mediator of RNA polymerase II transcription complex subunit 8 Helicase_IV_N PF12462.8 CAV25975.1 - 5.8e-57 192.1 4.5 5.8e-57 192.1 4.5 3.6 3 1 1 4 4 4 1 DNA helicase IV / RNA helicase N terminal UvrD-helicase PF00580.21 CAV25975.1 - 2.6e-43 148.8 0.2 2.6e-43 148.8 0.2 2.3 3 0 0 3 3 3 1 UvrD/REP helicase N-terminal domain AAA_19 PF13245.6 CAV25975.1 - 1.3e-27 96.9 0.0 4e-27 95.4 0.0 1.8 1 0 0 1 1 1 1 AAA domain UvrD_C PF13361.6 CAV25975.1 - 7.6e-19 68.3 6.8 3.1e-17 63.0 0.0 3.1 2 2 1 3 3 3 2 UvrD-like helicase C-terminal domain UvrD_C_2 PF13538.6 CAV25975.1 - 3.7e-12 45.9 0.4 1.2e-10 41.0 0.2 3.2 2 1 0 2 2 2 1 UvrD-like helicase C-terminal domain AAA_30 PF13604.6 CAV25975.1 - 5.3e-08 32.8 0.0 5.4e-05 23.0 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_12 PF13087.6 CAV25975.1 - 1.9e-07 30.9 0.1 4.4e-06 26.5 0.0 2.7 2 1 1 3 3 3 1 AAA domain Viral_helicase1 PF01443.18 CAV25975.1 - 8e-05 22.5 0.1 0.015 15.1 0.1 3.2 2 1 0 2 2 2 1 Viral (Superfamily 1) RNA helicase ResIII PF04851.15 CAV25975.1 - 0.0024 17.9 0.8 0.012 15.7 0.1 2.4 2 1 1 3 3 3 1 Type III restriction enzyme, res subunit Tropomyosin_1 PF12718.7 CAV25975.1 - 0.0093 16.1 0.4 0.033 14.4 0.4 1.9 1 0 0 1 1 1 1 Tropomyosin like DUF272 PF03312.15 CAV25975.1 - 0.0099 16.1 0.2 0.027 14.7 0.2 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF272) DEAD PF00270.29 CAV25975.1 - 0.014 15.2 0.4 0.39 10.5 0.0 2.8 3 0 0 3 3 3 0 DEAD/DEAH box helicase FtsK_SpoIIIE PF01580.18 CAV25975.1 - 0.14 11.5 0.0 0.49 9.7 0.0 1.9 1 1 1 2 2 2 0 FtsK/SpoIIIE family Glyoxalase PF00903.25 CAV25976.1 - 2.4e-06 27.8 0.0 3.4e-06 27.3 0.0 1.2 1 0 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_6 PF18029.1 CAV25976.1 - 0.0015 19.3 0.1 0.0033 18.2 0.1 1.6 1 1 0 1 1 1 1 Glyoxalase-like domain Transketolase_N PF00456.21 CAV25977.1 - 3.3e-167 555.5 0.1 5e-167 555.0 0.1 1.3 1 0 0 1 1 1 1 Transketolase, thiamine diphosphate binding domain Transket_pyr PF02779.24 CAV25977.1 - 7.8e-48 162.5 0.2 7.8e-48 162.5 0.2 1.7 2 0 0 2 2 2 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.20 CAV25977.1 - 6.3e-20 71.3 0.0 1.3e-19 70.3 0.0 1.6 1 0 0 1 1 1 1 Transketolase, C-terminal domain DXP_synthase_N PF13292.6 CAV25977.1 - 1.2e-06 27.9 0.0 0.004 16.4 0.1 2.5 1 1 1 2 2 2 2 1-deoxy-D-xylulose-5-phosphate synthase E1_dh PF00676.20 CAV25977.1 - 0.00018 20.6 0.0 0.00032 19.8 0.0 1.4 1 0 0 1 1 1 1 Dehydrogenase E1 component TPP_enzyme_C PF02775.21 CAV25977.1 - 0.0017 18.2 1.1 0.057 13.2 1.1 2.6 1 1 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain TAL_FSA PF00923.19 CAV25979.1 - 4.1e-99 331.6 0.1 4.7e-99 331.4 0.1 1.0 1 0 0 1 1 1 1 Transaldolase/Fructose-6-phosphate aldolase Sugar-bind PF04198.13 CAV25981.1 - 7.6e-76 254.6 0.1 1e-75 254.2 0.1 1.2 1 0 0 1 1 1 1 Putative sugar-binding domain HTH_23 PF13384.6 CAV25981.1 - 0.00011 21.9 0.1 0.0013 18.5 0.0 2.6 3 0 0 3 3 3 1 Homeodomain-like domain HTH_28 PF13518.6 CAV25981.1 - 0.00025 21.1 0.2 0.03 14.4 0.0 3.1 3 0 0 3 3 3 1 Helix-turn-helix domain HTH_24 PF13412.6 CAV25981.1 - 0.0014 18.1 0.0 0.0032 17.0 0.0 1.6 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding TrmB PF01978.19 CAV25981.1 - 0.0015 18.3 0.1 0.0045 16.9 0.1 1.8 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB Sigma70_r4 PF04545.16 CAV25981.1 - 0.0028 17.2 0.1 0.0094 15.5 0.1 1.9 2 0 0 2 2 2 1 Sigma-70, region 4 Sigma70_r4_2 PF08281.12 CAV25981.1 - 0.0071 16.0 0.4 0.058 13.1 0.1 2.3 2 0 0 2 2 2 1 Sigma-70, region 4 HTH_Crp_2 PF13545.6 CAV25981.1 - 0.0075 16.2 0.0 0.02 14.9 0.0 1.7 1 0 0 1 1 1 1 Crp-like helix-turn-helix domain Phage_antitermQ PF06530.12 CAV25981.1 - 0.016 15.1 0.1 0.031 14.2 0.1 1.5 1 0 0 1 1 1 0 Phage antitermination protein Q MarR PF01047.22 CAV25981.1 - 0.016 15.1 0.0 0.043 13.7 0.0 1.6 1 0 0 1 1 1 0 MarR family MarR_2 PF12802.7 CAV25981.1 - 0.029 14.2 0.1 0.12 12.3 0.0 2.1 2 0 0 2 2 2 0 MarR family Sigma70_ECF PF07638.11 CAV25981.1 - 0.068 13.1 0.1 0.19 11.6 0.0 1.8 2 0 0 2 2 2 0 ECF sigma factor GntR PF00392.21 CAV25981.1 - 0.079 12.6 0.1 3.9 7.2 0.0 3.1 3 0 0 3 3 3 0 Bacterial regulatory proteins, gntR family Big_9 PF17963.1 CAV25983.1 - 1.3e-11 45.0 2.4 5.7e-05 23.8 0.0 3.6 3 0 0 3 3 3 2 Bacterial Ig domain Peptidase_M6 PF05547.11 CAV25983.1 - 5.1e-11 41.6 3.7 9.5e-11 40.7 3.7 1.4 1 0 0 1 1 1 1 Immune inhibitor A peptidase M6 Cadherin_4 PF17803.1 CAV25983.1 - 7.6e-09 36.1 5.1 0.0026 18.4 0.0 3.8 3 1 0 3 3 3 2 Bacterial cadherin-like domain Cadherin_3 PF16184.5 CAV25983.1 - 0.00034 20.6 0.2 0.0027 17.7 0.2 2.5 2 0 0 2 2 2 1 Cadherin-like Peptidase_M7 PF02031.16 CAV25983.1 - 0.0098 16.0 0.2 0.024 14.8 0.2 1.6 1 0 0 1 1 1 1 Streptomyces extracellular neutral proteinase (M7) family EF-hand_5 PF13202.6 CAV25983.1 - 0.017 14.6 0.1 0.059 12.9 0.1 2.0 1 0 0 1 1 1 0 EF hand Peptidase_M64 PF09471.10 CAV25983.1 - 0.021 14.4 0.1 0.038 13.5 0.1 1.3 1 0 0 1 1 1 0 IgA Peptidase M64 HTH_1 PF00126.27 CAV25984.1 - 7e-18 64.3 0.0 1.1e-17 63.7 0.0 1.3 1 0 0 1 1 1 1 Bacterial regulatory helix-turn-helix protein, lysR family HTH_30 PF13556.6 CAV25984.1 - 0.013 15.3 0.0 0.029 14.2 0.0 1.6 1 0 0 1 1 1 0 PucR C-terminal helix-turn-helix domain HTH_5 PF01022.20 CAV25984.1 - 0.091 12.6 0.0 0.22 11.4 0.0 1.6 1 0 0 1 1 1 0 Bacterial regulatory protein, arsR family DUF2533 PF10752.9 CAV25984.1 - 0.11 13.0 0.0 0.36 11.3 0.0 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF2533) Peptidase_A24 PF01478.18 CAV25986.1 - 4.7e-10 39.8 8.6 8.4e-10 39.0 8.6 1.3 1 0 0 1 1 1 1 Type IV leader peptidase family SPC12 PF06645.13 CAV25986.1 - 0.014 15.5 0.3 0.014 15.5 0.3 2.6 3 0 0 3 3 3 0 Microsomal signal peptidase 12 kDa subunit (SPC12) DUF3488 PF11992.8 CAV25986.1 - 7.7 5.4 7.3 1.8 7.4 0.4 2.1 1 1 0 2 2 2 0 Domain of unknown function (DUF3488) Flp_Fap PF04964.14 CAV25988.1 - 1.4e-10 40.8 1.2 1.9e-10 40.4 1.2 1.3 1 0 0 1 1 1 1 Flp/Fap pilin component TadF PF16964.5 CAV25988.1 - 0.0066 16.2 0.0 0.0075 16.0 0.0 1.1 1 0 0 1 1 1 1 Putative tight adherence pilin protein F RcpC PF16976.5 CAV25990.1 - 0.00032 20.7 0.3 0.00054 20.0 0.3 1.3 1 0 0 1 1 1 1 Flp pilus assembly protein RcpC/CpaB ChapFlgA PF13144.6 CAV25990.1 - 0.024 14.7 0.0 0.05 13.7 0.0 1.5 1 0 0 1 1 1 0 Chaperone for flagella basal body P-ring formation Secretin PF00263.21 CAV25991.1 - 4.4e-42 143.6 0.9 1.2e-41 142.2 0.9 1.8 1 0 0 1 1 1 1 Bacterial type II and III secretion system protein T2SS-T3SS_pil_N PF13629.6 CAV25991.1 - 5.2e-19 67.7 0.6 1.1e-18 66.7 0.6 1.6 1 0 0 1 1 1 1 Pilus formation protein N terminal region BON PF04972.17 CAV25991.1 - 0.0013 19.0 1.0 0.0031 17.8 0.1 2.1 2 0 0 2 2 2 1 BON domain Pilus_CpaD PF09476.10 CAV25993.1 - 0.0019 18.0 0.0 0.021 14.6 0.0 2.0 1 1 0 1 1 1 1 Pilus biogenesis CpaD protein (pilus_cpaD) Lipoprotein_18 PF06804.11 CAV25993.1 - 0.0036 16.4 0.0 0.0076 15.3 0.0 1.5 2 0 0 2 2 2 1 NlpB/DapX lipoprotein DUF5018 PF16410.5 CAV25993.1 - 0.059 12.1 0.1 0.69 8.5 0.1 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF5018) Elf4 PF07011.11 CAV25993.1 - 0.086 12.8 0.0 0.26 11.2 0.0 1.8 2 0 0 2 2 2 0 Early Flowering 4 domain AAA_31 PF13614.6 CAV25995.1 - 1.3e-07 31.7 1.7 5.1e-07 29.8 1.7 2.0 1 1 0 1 1 1 1 AAA domain CbiA PF01656.23 CAV25995.1 - 5.6e-06 26.4 0.6 1.2e-05 25.3 0.1 1.8 2 0 0 2 2 2 1 CobQ/CobB/MinD/ParA nucleotide binding domain ParA PF10609.9 CAV25995.1 - 0.00036 20.1 0.6 0.00059 19.4 0.6 1.4 1 0 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase ArsA_ATPase PF02374.15 CAV25995.1 - 0.00062 19.0 1.1 0.0017 17.6 0.3 1.9 1 1 0 2 2 2 1 Anion-transporting ATPase Ribosomal_L5 PF00281.19 CAV25995.1 - 0.0075 16.6 0.1 0.025 14.9 0.0 1.9 2 0 0 2 2 2 1 Ribosomal protein L5 T2SSE PF00437.20 CAV25996.1 - 6.4e-82 274.7 2.3 9.2e-82 274.2 2.3 1.2 1 0 0 1 1 1 1 Type II/IV secretion system protein ABC_tran PF00005.27 CAV25996.1 - 9.9e-05 22.9 0.2 0.00027 21.5 0.0 1.9 2 0 0 2 2 2 1 ABC transporter AAA_23 PF13476.6 CAV25996.1 - 0.00024 21.6 0.1 0.00024 21.6 0.1 2.3 2 1 0 2 2 2 1 AAA domain AAA_28 PF13521.6 CAV25996.1 - 0.0005 20.3 0.2 0.00097 19.4 0.2 1.5 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 CAV25996.1 - 0.001 19.5 0.2 0.003 18.0 0.0 1.8 2 0 0 2 2 2 1 AAA ATPase domain FtsK_SpoIIIE PF01580.18 CAV25996.1 - 0.0012 18.3 0.6 0.0043 16.4 0.0 2.1 2 0 0 2 2 2 1 FtsK/SpoIIIE family AAA_29 PF13555.6 CAV25996.1 - 0.0013 18.5 0.3 0.003 17.3 0.3 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain Zeta_toxin PF06414.12 CAV25996.1 - 0.0019 17.5 0.0 0.0036 16.6 0.0 1.4 1 0 0 1 1 1 1 Zeta toxin AAA_21 PF13304.6 CAV25996.1 - 0.0039 17.1 0.2 0.35 10.6 0.0 3.0 3 0 0 3 3 3 1 AAA domain, putative AbiEii toxin, Type IV TA system Mg_chelatase PF01078.21 CAV25996.1 - 0.0053 16.2 0.1 0.013 14.9 0.1 1.6 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI cobW PF02492.19 CAV25996.1 - 0.011 15.3 1.6 0.08 12.5 0.0 2.7 2 1 1 3 3 3 0 CobW/HypB/UreG, nucleotide-binding domain AAA_2 PF07724.14 CAV25996.1 - 0.013 15.6 0.1 0.052 13.7 0.0 2.0 2 0 0 2 2 2 0 AAA domain (Cdc48 subfamily) Sec2p PF06428.11 CAV25996.1 - 0.018 15.0 0.9 0.042 13.8 0.9 1.5 1 0 0 1 1 1 0 GDP/GTP exchange factor Sec2p RsgA_GTPase PF03193.16 CAV25996.1 - 0.029 14.3 0.3 0.063 13.2 0.1 1.7 2 0 0 2 2 1 0 RsgA GTPase Sigma54_activ_2 PF14532.6 CAV25996.1 - 0.035 14.2 0.0 0.11 12.6 0.0 1.8 1 0 0 1 1 1 0 Sigma-54 interaction domain DAP3 PF10236.9 CAV25996.1 - 0.039 13.1 0.5 9.9 5.2 0.0 2.9 3 0 0 3 3 3 0 Mitochondrial ribosomal death-associated protein 3 MMR_HSR1 PF01926.23 CAV25996.1 - 0.04 14.0 0.2 0.12 12.4 0.0 1.9 2 0 0 2 2 2 0 50S ribosome-binding GTPase IIGP PF05049.13 CAV25996.1 - 0.077 12.0 0.8 0.13 11.3 0.1 1.7 2 0 0 2 2 2 0 Interferon-inducible GTPase (IIGP) AAA_7 PF12775.7 CAV25996.1 - 0.088 12.3 0.1 0.21 11.1 0.1 1.6 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_22 PF13401.6 CAV25996.1 - 0.11 12.8 0.6 0.69 10.2 0.0 2.5 3 0 0 3 3 3 0 AAA domain TsaE PF02367.17 CAV25996.1 - 0.14 12.2 0.7 0.3 11.1 0.1 1.9 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE TrwB_AAD_bind PF10412.9 CAV25996.1 - 0.31 9.9 0.1 0.31 9.9 0.1 2.1 3 0 0 3 3 3 0 Type IV secretion-system coupling protein DNA-binding domain AAA_19 PF13245.6 CAV25996.1 - 1 9.7 5.2 0.26 11.6 0.7 2.3 2 1 0 2 2 2 0 AAA domain T2SSF PF00482.23 CAV25998.1 - 3.7e-17 62.4 0.1 2.2e-16 59.9 0.0 2.0 2 0 0 2 2 2 1 Type II secretion system (T2SS), protein F Spore_III_AB PF09548.10 CAV25998.1 - 0.036 14.2 0.0 0.071 13.2 0.0 1.6 1 0 0 1 1 1 0 Stage III sporulation protein AB (spore_III_AB) PrgI PF12666.7 CAV25998.1 - 0.12 13.1 0.1 0.12 13.1 0.1 2.6 3 1 0 3 3 3 0 PrgI family protein Peptidase_A22B PF04258.13 CAV25998.1 - 0.14 11.7 4.6 0.04 13.5 1.7 1.7 2 0 0 2 2 2 0 Signal peptide peptidase T2SSF PF00482.23 CAV26000.1 - 1.4e-15 57.4 2.1 1.4e-15 57.4 2.1 1.9 2 0 0 2 2 2 1 Type II secretion system (T2SS), protein F EXS PF03124.14 CAV26000.1 - 0.044 13.1 1.2 0.052 12.9 1.2 1.3 1 0 0 1 1 1 0 EXS family DUF679 PF05078.12 CAV26000.1 - 0.058 13.4 0.1 1.7 8.6 0.0 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF679) COX16 PF14138.6 CAV26000.1 - 0.2 12.2 1.0 0.35 11.4 0.0 2.0 2 0 0 2 2 2 0 Cytochrome c oxidase assembly protein COX16 HemY_N PF07219.13 CAV26000.1 - 1.2 9.4 7.2 3.1 8.0 0.0 2.8 3 0 0 3 3 3 0 HemY protein N-terminus TPR_19 PF14559.6 CAV26002.1 - 4.8e-08 33.4 6.0 0.041 14.4 0.0 4.9 3 2 2 5 5 5 3 Tetratricopeptide repeat TPR_16 PF13432.6 CAV26002.1 - 6.5e-06 26.7 0.5 2.2e-05 25.0 0.2 2.1 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_2 PF07719.17 CAV26002.1 - 8.6e-06 25.5 5.6 0.016 15.3 0.2 3.1 3 0 0 3 3 3 2 Tetratricopeptide repeat ANAPC3 PF12895.7 CAV26002.1 - 2.5e-05 24.4 2.8 3.2e-05 24.1 1.1 2.0 2 0 0 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_12 PF13424.6 CAV26002.1 - 9.5e-05 22.6 1.0 0.59 10.5 0.1 3.0 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_21 PF09976.9 CAV26002.1 - 0.00029 20.6 3.2 0.00041 20.1 1.1 2.2 2 1 0 2 2 2 1 Tetratricopeptide repeat-like domain TPR_1 PF00515.28 CAV26002.1 - 0.0009 19.0 4.4 0.08 12.8 0.0 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.6 CAV26002.1 - 0.0011 19.5 0.4 0.59 11.1 0.0 3.4 2 1 1 3 3 3 1 Tetratricopeptide repeat Coatomer_E PF04733.14 CAV26002.1 - 0.0015 18.0 0.5 0.2 11.0 0.2 2.5 1 1 2 3 3 3 1 Coatomer epsilon subunit TPR_8 PF13181.6 CAV26002.1 - 0.0021 18.1 9.4 1.3 9.4 0.5 4.5 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_11 PF13414.6 CAV26002.1 - 0.028 14.1 1.7 6.1 6.6 0.0 2.5 2 0 0 2 2 2 0 TPR repeat TPR_10 PF13374.6 CAV26002.1 - 0.059 13.3 1.5 7.4 6.6 0.0 3.0 3 0 0 3 3 2 0 Tetratricopeptide repeat SPOR PF05036.13 CAV26002.1 - 0.091 13.1 0.0 0.7 10.3 0.0 2.5 1 1 1 2 2 2 0 Sporulation related domain TPR_7 PF13176.6 CAV26002.1 - 0.11 12.6 0.5 25 5.2 0.0 3.7 3 0 0 3 3 3 0 Tetratricopeptide repeat TadE PF07811.12 CAV26004.1 - 1.6e-06 28.2 1.0 2.6e-06 27.6 1.0 1.3 1 0 0 1 1 1 1 TadE-like protein TadF PF16964.5 CAV26005.1 - 1.1e-23 84.0 0.0 1.5e-23 83.5 0.0 1.1 1 0 0 1 1 1 1 Putative tight adherence pilin protein F VWA PF00092.28 CAV26007.1 - 6.8e-12 46.0 0.3 5.4e-06 26.8 0.1 2.3 2 0 0 2 2 2 2 von Willebrand factor type A domain VWA_2 PF13519.6 CAV26007.1 - 9.1e-07 29.5 0.0 0.057 14.1 0.0 2.6 2 0 0 2 2 2 2 von Willebrand factor type A domain Tad PF13400.6 CAV26007.1 - 0.0001 22.5 5.3 0.00018 21.7 5.3 1.4 1 0 0 1 1 1 1 Putative Flp pilus-assembly TadE/G-like OmpA PF00691.20 CAV26009.1 - 3e-15 56.4 0.1 6e-15 55.4 0.0 1.5 2 0 0 2 2 2 1 OmpA family EAL PF00563.20 CAV26010.1 - 7.4e-68 228.6 0.1 1.4e-67 227.7 0.1 1.5 1 0 0 1 1 1 1 EAL domain GGDEF PF00990.21 CAV26010.1 - 5.8e-40 136.7 0.0 2.6e-39 134.6 0.0 2.0 2 0 0 2 2 2 1 Diguanylate cyclase, GGDEF domain dCache_1 PF02743.18 CAV26010.1 - 0.00027 20.8 1.2 0.00053 19.8 1.2 1.5 1 0 0 1 1 1 1 Cache domain OppC_N PF12911.7 CAV26010.1 - 0.053 13.5 0.4 0.15 12.0 0.1 1.9 2 0 0 2 2 2 0 N-terminal TM domain of oligopeptide transport permease C DUF3283 PF11686.8 CAV26010.1 - 0.074 12.9 0.0 0.38 10.6 0.0 2.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3283) Rhodanese PF00581.20 CAV26012.1 - 1.8e-26 92.7 0.0 7.8e-14 52.1 0.0 2.1 2 0 0 2 2 2 2 Rhodanese-like domain DOT1 PF08123.13 CAV26012.1 - 0.13 11.8 0.0 0.23 11.0 0.0 1.3 1 0 0 1 1 1 0 Histone methylation protein DOT1 ThiC-associated PF13667.6 CAV26012.1 - 0.16 11.8 0.0 0.88 9.4 0.0 2.3 3 0 0 3 3 3 0 ThiC-associated domain Hamartin PF04388.12 CAV26017.1 - 0.092 11.4 4.7 0.11 11.2 4.7 1.1 1 0 0 1 1 1 0 Hamartin protein DUF4842 PF16130.5 CAV26019.1 - 1.4e-58 198.6 0.0 2.2e-58 197.9 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4842) DUF4394 PF14339.6 CAV26019.1 - 1.5e-05 24.5 1.6 9.3e-05 21.9 0.0 2.9 3 1 1 4 4 4 1 Domain of unknown function (DUF4394) ThiF PF00899.21 CAV26021.1 - 4.2e-63 212.9 0.5 5.2e-63 212.7 0.5 1.0 1 0 0 1 1 1 1 ThiF family Sacchrp_dh_NADP PF03435.18 CAV26021.1 - 0.00011 22.4 0.9 0.00049 20.3 0.9 1.9 1 1 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain DAO PF01266.24 CAV26021.1 - 0.0079 15.8 0.0 0.0091 15.6 0.0 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_7 PF13241.6 CAV26021.1 - 0.011 16.2 0.0 0.021 15.3 0.0 1.4 1 0 0 1 1 1 0 Putative NAD(P)-binding Shikimate_DH PF01488.20 CAV26021.1 - 0.016 15.3 0.0 0.027 14.5 0.0 1.3 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase ApbA PF02558.16 CAV26021.1 - 0.027 14.1 0.1 0.042 13.5 0.1 1.3 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA MoeA_N PF03453.17 CAV26023.1 - 1.3e-45 155.0 0.0 3e-45 153.8 0.0 1.6 2 0 0 2 2 2 1 MoeA N-terminal region (domain I and II) MoCF_biosynth PF00994.24 CAV26023.1 - 5.4e-25 87.7 0.0 8.2e-25 87.1 0.0 1.3 1 0 0 1 1 1 1 Probable molybdopterin binding domain MoeA_C PF03454.15 CAV26023.1 - 6.9e-21 74.2 0.0 1.4e-20 73.2 0.0 1.6 1 0 0 1 1 1 1 MoeA C-terminal region (domain IV) 7TMR-HDED PF07697.11 CAV26023.1 - 0.12 12.4 0.1 0.23 11.5 0.1 1.5 2 0 0 2 2 2 0 7TM-HD extracellular GTP_cyclohydroI PF01227.22 CAV26025.1 - 1.5e-62 210.2 0.7 1.9e-62 209.8 0.7 1.2 1 0 0 1 1 1 1 GTP cyclohydrolase I QueF PF14489.6 CAV26025.1 - 0.017 15.3 0.0 0.04 14.1 0.0 1.6 1 0 0 1 1 1 0 QueF-like protein Peptidase_C69 PF03577.15 CAV26026.1 - 4.5e-96 322.2 0.1 5.9e-96 321.8 0.1 1.1 1 0 0 1 1 1 1 Peptidase family C69 DUF2660 PF10859.8 CAV26026.1 - 0.17 12.3 1.2 0.4 11.2 1.2 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2660) CHASE3 PF05227.13 CAV26028.1 - 0.0097 15.8 0.3 1.6 8.6 0.1 2.1 2 0 0 2 2 2 2 CHASE3 domain YaeQ PF07152.12 CAV26030.1 - 3.9e-70 234.9 0.0 4.4e-70 234.8 0.0 1.0 1 0 0 1 1 1 1 YaeQ protein DUF1670 PF07900.11 CAV26030.1 - 0.011 15.1 0.0 0.015 14.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1670) CSD PF00313.22 CAV26032.1 - 3.2e-28 97.4 1.6 3.4e-28 97.3 1.6 1.0 1 0 0 1 1 1 1 'Cold-shock' DNA-binding domain CusF_Ec PF11604.8 CAV26032.1 - 0.059 13.3 0.1 0.082 12.9 0.1 1.3 1 0 0 1 1 1 0 Copper binding periplasmic protein CusF OB_RNB PF08206.11 CAV26032.1 - 0.1 12.3 0.5 0.12 12.1 0.5 1.4 1 1 0 1 1 1 0 Ribonuclease B OB domain GSDH PF07995.11 CAV26034.1 - 3.1e-112 375.2 0.2 3.6e-112 374.9 0.2 1.0 1 0 0 1 1 1 1 Glucose / Sorbosone dehydrogenase MFS_1 PF07690.16 CAV26035.1 - 3.5e-43 147.9 53.0 9.5e-39 133.3 26.6 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 CAV26035.1 - 9.1e-09 34.7 20.2 3.1e-08 32.9 6.1 2.9 2 2 1 3 3 3 2 Sugar (and other) transporter ABC_tran PF00005.27 CAV26037.1 - 5.7e-29 101.4 0.0 8.3e-29 100.8 0.0 1.3 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 CAV26037.1 - 3.9e-10 39.6 0.4 5.6e-05 22.7 0.0 2.1 1 1 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 CAV26037.1 - 1.3e-09 38.3 2.1 1.4e-05 25.1 0.0 2.1 1 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_16 PF13191.6 CAV26037.1 - 2.5e-05 24.7 0.1 4.9e-05 23.8 0.1 1.5 1 1 0 1 1 1 1 AAA ATPase domain AAA_15 PF13175.6 CAV26037.1 - 0.00016 21.5 0.1 0.00029 20.7 0.1 1.3 1 0 0 1 1 1 1 AAA ATPase domain AAA_29 PF13555.6 CAV26037.1 - 0.00016 21.3 0.1 0.00029 20.5 0.1 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_13 PF13166.6 CAV26037.1 - 0.00019 20.2 0.1 0.18 10.4 0.0 2.1 2 0 0 2 2 2 2 AAA domain RsgA_GTPase PF03193.16 CAV26037.1 - 0.0003 20.7 0.1 0.00053 19.9 0.1 1.3 1 0 0 1 1 1 1 RsgA GTPase AAA_23 PF13476.6 CAV26037.1 - 0.00036 21.1 0.1 0.00068 20.2 0.1 1.4 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 CAV26037.1 - 0.0005 20.4 0.3 0.0077 16.5 0.3 2.1 1 1 0 1 1 1 1 AAA domain ABC_ATPase PF09818.9 CAV26037.1 - 0.00098 18.0 0.0 0.59 8.9 0.0 2.4 2 1 0 2 2 2 2 Predicted ATPase of the ABC class KAP_NTPase PF07693.14 CAV26037.1 - 0.021 14.1 0.0 0.022 14.0 0.0 1.1 1 0 0 1 1 1 0 KAP family P-loop domain Zeta_toxin PF06414.12 CAV26037.1 - 0.031 13.5 0.0 0.056 12.7 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin AAA_18 PF13238.6 CAV26037.1 - 0.032 14.8 0.0 0.34 11.5 0.0 2.1 1 1 0 1 1 1 0 AAA domain AAA_14 PF13173.6 CAV26037.1 - 0.033 14.2 0.0 3.8 7.5 0.0 2.3 2 1 0 2 2 2 0 AAA domain MMR_HSR1 PF01926.23 CAV26037.1 - 0.036 14.1 0.2 0.16 12.1 0.1 2.0 2 0 0 2 2 2 0 50S ribosome-binding GTPase AAA_30 PF13604.6 CAV26037.1 - 0.041 13.6 0.0 0.066 12.9 0.0 1.4 1 1 0 1 1 1 0 AAA domain NACHT PF05729.12 CAV26037.1 - 0.055 13.4 0.3 0.68 9.8 0.0 2.2 2 0 0 2 2 2 0 NACHT domain AAA_25 PF13481.6 CAV26037.1 - 0.058 13.0 0.0 0.19 11.3 0.0 1.8 2 0 0 2 2 2 0 AAA domain DLIC PF05783.11 CAV26037.1 - 0.1 11.4 0.0 0.15 10.9 0.0 1.1 1 0 0 1 1 1 0 Dynein light intermediate chain (DLIC) Dynamin_N PF00350.23 CAV26037.1 - 0.14 12.2 0.2 0.26 11.3 0.2 1.4 1 0 0 1 1 1 0 Dynamin family ATP_bind_1 PF03029.17 CAV26037.1 - 0.15 11.8 0.2 0.36 10.6 0.1 1.7 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein AAA_33 PF13671.6 CAV26037.1 - 0.15 12.2 0.1 0.45 10.7 0.1 1.8 2 0 0 2 2 2 0 AAA domain FhuF_C PF11575.8 CAV26039.1 - 0.00025 20.9 8.6 0.00041 20.2 8.6 1.4 1 0 0 1 1 1 1 FhuF 2Fe-2S C-terminal domain RdRP_2 PF00978.21 CAV26039.1 - 0.1 11.5 0.0 0.14 11.0 0.0 1.1 1 0 0 1 1 1 0 RNA dependent RNA polymerase HTH_18 PF12833.7 CAV26041.1 - 1.4e-23 82.9 0.0 2e-23 82.5 0.0 1.2 1 0 0 1 1 1 1 Helix-turn-helix domain Cass2 PF14526.6 CAV26041.1 - 1.8e-16 60.6 0.0 2.8e-16 60.0 0.0 1.3 1 0 0 1 1 1 1 Integron-associated effector binding protein GyrI-like PF06445.15 CAV26041.1 - 8.8e-16 58.6 0.1 1.3e-15 58.0 0.1 1.2 1 0 0 1 1 1 1 GyrI-like small molecule binding domain HTH_AraC PF00165.23 CAV26041.1 - 1.6e-15 56.7 0.1 1.9e-07 31.0 0.0 2.4 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family HTH_3 PF01381.22 CAV26041.1 - 0.16 12.1 0.0 2.6 8.2 0.0 2.6 2 1 0 2 2 2 0 Helix-turn-helix TonB_dep_Rec PF00593.24 CAV26043.1 - 1.3e-55 190.2 41.3 1.8e-55 189.7 41.3 1.2 1 0 0 1 1 1 1 TonB dependent receptor Plug PF07715.15 CAV26043.1 - 2.4e-17 63.4 0.0 9.9e-17 61.5 0.0 2.2 1 0 0 1 1 1 1 TonB-dependent Receptor Plug Domain Peripla_BP_2 PF01497.18 CAV26044.1 - 1.8e-24 86.6 0.4 5.6e-24 85.0 0.4 1.7 1 1 0 1 1 1 1 Periplasmic binding protein ANAPC4_WD40 PF12894.7 CAV26044.1 - 0.17 12.2 0.1 0.4 11.0 0.1 1.7 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 4 WD40 domain FecCD PF01032.18 CAV26046.1 - 2.6e-129 430.7 88.2 1.8e-67 227.6 42.1 2.1 2 0 0 2 2 2 2 FecCD transport family ABC-3 PF00950.17 CAV26046.1 - 0.0046 16.5 59.6 0.02 14.4 26.5 2.7 2 1 1 3 3 3 2 ABC 3 transport family ECH_1 PF00378.20 CAV26048.1 - 2.1e-31 109.2 0.0 3.1e-31 108.6 0.0 1.2 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 CAV26048.1 - 1.1e-27 97.4 0.0 1.6e-27 96.9 0.0 1.2 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase Toluene_X PF03349.16 CAV26050.1 - 4.2e-58 197.0 14.0 4.4e-35 121.1 3.5 2.2 1 1 1 2 2 2 2 Outer membrane protein transport protein (OMPP1/FadL/TodX) OMP_b-brl PF13505.6 CAV26050.1 - 9.3e-13 48.7 11.1 4.3e-09 36.8 3.5 2.9 1 1 0 2 2 2 2 Outer membrane protein beta-barrel domain DUF2490 PF10677.9 CAV26050.1 - 0.00015 21.8 3.3 0.43 10.5 0.1 3.0 2 2 0 2 2 2 2 Protein of unknown function (DUF2490) TonB_dep_Rec PF00593.24 CAV26050.1 - 0.0057 16.6 15.1 0.061 13.2 3.1 2.4 1 1 1 2 2 2 2 TonB dependent receptor OMP_b-brl_2 PF13568.6 CAV26050.1 - 0.0064 16.5 0.1 2.2 8.3 0.1 2.9 2 1 0 2 2 2 1 Outer membrane protein beta-barrel domain PorP_SprF PF11751.8 CAV26050.1 - 0.0073 15.9 0.0 0.021 14.3 0.0 1.9 1 1 0 1 1 1 1 Type IX secretion system membrane protein PorP/SprF Porin_7 PF16956.5 CAV26050.1 - 0.0075 16.0 1.7 0.013 15.1 1.7 1.4 1 0 0 1 1 1 1 Putative general bacterial porin DUF3078 PF11276.8 CAV26050.1 - 0.021 15.3 2.3 0.33 11.4 0.3 3.1 2 1 0 2 2 2 0 Protein of unknown function (DUF3078) YadA_anchor PF03895.15 CAV26050.1 - 0.023 14.8 4.3 2.1 8.5 0.0 4.7 4 1 0 4 4 4 0 YadA-like membrane anchor domain Pom PF17251.2 CAV26050.1 - 0.026 13.8 1.5 0.076 12.3 0.3 2.0 1 1 0 2 2 2 0 Protochlamydia outer membrane protein BBP2_2 PF10082.9 CAV26050.1 - 0.031 13.1 0.3 0.32 9.8 0.0 2.3 1 1 1 2 2 2 0 Putative beta-barrel porin 2 MipA PF06629.12 CAV26050.1 - 0.24 11.7 12.2 7.8 6.7 5.3 3.7 1 1 2 3 3 3 0 MltA-interacting protein MipA Porin_2 PF02530.14 CAV26050.1 - 0.9 8.7 8.2 14 4.8 8.2 2.2 1 1 0 1 1 1 0 Porin subfamily Oxidored_FMN PF00724.20 CAV26054.1 - 3.6e-66 223.8 0.0 4.4e-66 223.5 0.0 1.0 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family Dus PF01207.17 CAV26054.1 - 0.00058 19.0 0.0 0.00095 18.3 0.0 1.4 1 0 0 1 1 1 1 Dihydrouridine synthase (Dus) DUF561 PF04481.12 CAV26054.1 - 0.0085 15.3 0.0 0.014 14.6 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF561) FGAR-AT_linker PF18072.1 CAV26054.1 - 0.14 12.7 0.0 0.37 11.4 0.0 1.8 1 0 0 1 1 1 0 Formylglycinamide ribonucleotide amidotransferase linker domain NMO PF03060.15 CAV26054.1 - 0.15 11.5 0.2 0.28 10.5 0.2 1.3 1 0 0 1 1 1 0 Nitronate monooxygenase Hexapep PF00132.24 CAV26056.1 - 8.3e-13 47.5 3.2 7.6e-10 38.1 0.2 2.9 3 0 0 3 3 3 2 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 CAV26056.1 - 2.5e-08 33.5 0.8 1.1e-06 28.2 0.0 2.5 2 0 0 2 2 2 2 Hexapeptide repeat of succinyl-transferase ABC_membrane PF00664.23 CAV26058.1 - 7.7e-13 48.7 1.8 1.4e-12 47.8 1.8 1.4 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 CAV26058.1 - 0.0004 20.9 0.4 0.0034 17.9 0.0 2.3 1 1 1 2 2 2 1 ABC transporter SMC_N PF02463.19 CAV26058.1 - 0.01 15.3 0.2 0.013 14.9 0.2 1.3 1 0 0 1 1 1 0 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 CAV26058.1 - 0.012 15.5 0.0 0.023 14.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system ATP1G1_PLM_MAT8 PF02038.16 CAV26058.1 - 0.25 10.8 1.2 18 4.8 0.0 2.7 2 0 0 2 2 2 0 ATP1G1/PLM/MAT8 family ABC_membrane PF00664.23 CAV26059.1 - 1.9e-16 60.5 14.0 2.6e-16 60.1 14.0 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 CAV26059.1 - 7.5e-15 55.6 0.0 2.3e-14 54.1 0.0 1.9 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 CAV26059.1 - 8e-07 29.2 0.0 0.00037 20.4 0.0 2.3 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 CAV26059.1 - 2.6e-05 23.9 0.2 7.6e-05 22.4 0.2 1.8 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_18 PF13238.6 CAV26059.1 - 0.00031 21.3 0.0 0.0012 19.4 0.0 2.0 1 0 0 1 1 1 1 AAA domain RsgA_GTPase PF03193.16 CAV26059.1 - 0.0028 17.6 0.0 0.0063 16.4 0.0 1.5 1 0 0 1 1 1 1 RsgA GTPase AAA_16 PF13191.6 CAV26059.1 - 0.0043 17.4 0.0 0.015 15.7 0.0 1.9 2 0 0 2 2 1 1 AAA ATPase domain AAA_23 PF13476.6 CAV26059.1 - 0.0064 17.0 0.2 0.0064 17.0 0.2 2.1 3 0 0 3 3 1 1 AAA domain Rad17 PF03215.15 CAV26059.1 - 0.013 15.5 0.0 0.028 14.3 0.0 1.5 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_22 PF13401.6 CAV26059.1 - 0.02 15.2 0.0 0.051 13.8 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.6 CAV26059.1 - 0.071 13.3 0.0 0.19 12.0 0.0 1.8 1 0 0 1 1 1 0 AAA domain SMC_N PF02463.19 CAV26059.1 - 0.081 12.3 1.0 1.3 8.5 0.1 2.7 3 0 0 3 3 3 0 RecF/RecN/SMC N terminal domain IstB_IS21 PF01695.17 CAV26059.1 - 0.083 12.6 0.0 0.31 10.8 0.0 1.9 2 0 0 2 2 2 0 IstB-like ATP binding protein NTPase_1 PF03266.15 CAV26059.1 - 0.13 12.2 0.0 0.25 11.3 0.0 1.4 1 0 0 1 1 1 0 NTPase Ctr PF04145.15 CAV26059.1 - 0.15 12.7 3.0 0.18 12.4 0.0 2.4 2 1 0 2 2 2 0 Ctr copper transporter family LapA_dom PF06305.11 CAV26059.1 - 0.28 11.0 5.4 0.56 10.1 1.0 2.7 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain HlyD_3 PF13437.6 CAV26061.1 - 1.4e-19 70.7 1.3 1.9e-15 57.4 0.0 3.0 3 1 0 3 3 3 2 HlyD family secretion protein HlyD PF00529.20 CAV26061.1 - 3.4e-09 36.4 0.0 3.3e-08 33.3 0.0 2.2 1 1 0 1 1 1 1 HlyD membrane-fusion protein of T1SS Biotin_lipoyl_2 PF13533.6 CAV26061.1 - 7.7e-08 32.1 3.5 8.4e-08 31.9 0.8 2.5 2 0 0 2 2 2 1 Biotin-lipoyl like Spc7 PF08317.11 CAV26061.1 - 0.0015 17.5 12.1 0.0015 17.5 12.1 2.1 1 1 1 2 2 2 1 Spc7 kinetochore protein OEP PF02321.18 CAV26061.1 - 0.0039 17.0 14.3 0.0039 17.0 14.3 2.2 1 1 1 2 2 2 1 Outer membrane efflux protein Biotin_lipoyl PF00364.22 CAV26061.1 - 0.006 16.4 1.7 0.015 15.1 0.2 2.3 2 1 0 2 2 2 1 Biotin-requiring enzyme PTS_EIIA_1 PF00358.20 CAV26061.1 - 0.0092 15.7 0.1 0.06 13.1 0.1 2.1 2 0 0 2 2 2 1 phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1 Baculo_PEP_C PF04513.12 CAV26061.1 - 0.016 15.2 8.7 0.034 14.2 0.4 2.8 2 1 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus CCDC84 PF14968.6 CAV26061.1 - 0.95 9.0 3.2 1.2 8.7 2.5 1.4 1 1 0 1 1 1 0 Coiled coil protein 84 DUF4094 PF13334.6 CAV26061.1 - 2.7 8.5 8.5 14 6.2 0.0 3.2 2 1 2 4 4 4 0 Domain of unknown function (DUF4094) ExsD PF16806.5 CAV26061.1 - 3.7 7.4 11.9 0.59 10.0 6.1 2.3 1 1 1 2 2 2 0 Antiactivator protein ExsD Cadherin_4 PF17803.1 CAV26063.1 - 3.5e-103 338.3 252.6 2.5e-10 40.8 2.5 24.2 21 2 0 21 21 21 18 Bacterial cadherin-like domain Big_9 PF17963.1 CAV26063.1 - 2.8e-87 287.6 301.5 3.3e-14 53.4 3.5 24.7 19 6 4 23 23 23 16 Bacterial Ig domain Cadherin_5 PF17892.1 CAV26063.1 - 1.6e-67 223.6 27.0 4.5e-31 106.7 4.4 19.7 21 2 0 21 21 21 10 Cadherin-like domain DUF3275 PF11679.8 CAV26063.1 - 0.54 10.2 4.7 0.96 9.4 0.0 3.6 4 0 0 4 4 4 0 Protein of unknown function (DUF3275) Staphylokinase PF02821.16 CAV26063.1 - 4.8 7.7 7.9 1.7 9.1 0.0 3.2 3 0 0 3 3 3 0 Staphylokinase/Streptokinase family Orn_DAP_Arg_deC PF00278.22 CAV26065.1 - 0.013 15.7 0.4 0.017 15.3 0.4 1.2 1 0 0 1 1 1 0 Pyridoxal-dependent decarboxylase, C-terminal sheet domain OEP PF02321.18 CAV26066.1 - 6.9e-17 61.9 35.8 7.2e-11 42.2 11.4 2.6 2 1 1 3 3 3 2 Outer membrane efflux protein HlyD_D23 PF16576.5 CAV26068.1 - 1.5e-75 253.1 0.0 2.7e-75 252.3 0.0 1.4 1 0 0 1 1 1 1 Barrel-sandwich domain of CusB or HlyD membrane-fusion CusF_Ec PF11604.8 CAV26068.1 - 6e-42 141.5 1.1 3.6e-20 71.7 0.2 2.6 2 0 0 2 2 2 2 Copper binding periplasmic protein CusF HlyD_3 PF13437.6 CAV26068.1 - 5.9e-18 65.5 0.0 1.2e-15 58.1 0.0 2.9 2 0 0 2 2 2 1 HlyD family secretion protein Biotin_lipoyl_2 PF13533.6 CAV26068.1 - 1.8e-05 24.5 0.1 0.076 12.9 0.0 2.5 2 0 0 2 2 2 2 Biotin-lipoyl like HlyD_D4 PF16572.5 CAV26068.1 - 0.0036 17.1 0.0 0.0085 15.9 0.0 1.7 1 0 0 1 1 1 1 Long alpha hairpin domain of cation efflux system protein, CusB Biotin_lipoyl PF00364.22 CAV26068.1 - 0.0043 16.9 0.1 4.9 7.0 0.0 3.0 2 0 0 2 2 2 2 Biotin-requiring enzyme PYNP_C PF07831.13 CAV26068.1 - 0.013 15.1 0.0 0.035 13.8 0.0 1.6 1 0 0 1 1 1 0 Pyrimidine nucleoside phosphorylase C-terminal domain Lipase3_N PF03893.16 CAV26068.1 - 0.052 13.6 0.0 0.1 12.6 0.0 1.4 1 0 0 1 1 1 0 Lipase 3 N-terminal region ACR_tran PF00873.19 CAV26070.1 - 4.5e-244 812.5 7.4 5.4e-244 812.3 7.4 1.0 1 0 0 1 1 1 1 AcrB/AcrD/AcrF family Patched PF02460.18 CAV26070.1 - 0.045 11.8 6.9 0.068 11.2 6.9 1.2 1 0 0 1 1 1 0 Patched family SoxE PF06525.11 CAV26071.1 - 0.0047 16.4 0.0 0.0079 15.7 0.0 1.4 1 0 0 1 1 1 1 Sulfocyanin (SoxE) domain Cu-oxidase_2 PF07731.14 CAV26071.1 - 0.013 15.3 3.7 0.037 13.8 3.7 1.9 1 1 0 1 1 1 0 Multicopper oxidase Fmp27_WPPW PF10359.9 CAV26073.1 - 0.036 12.9 20.1 0.043 12.7 20.1 1.0 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain PA26 PF04636.13 CAV26073.1 - 0.31 9.9 9.1 0.32 9.9 9.1 1.1 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) DUF3422 PF11902.8 CAV26073.1 - 0.52 9.4 2.2 0.72 8.9 2.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3422) Thioesterase PF00975.20 CAV26073.1 - 2.3 8.3 8.1 3 7.9 8.1 1.2 1 0 0 1 1 1 0 Thioesterase domain Exonuc_VII_L PF02601.15 CAV26073.1 - 2.6 7.5 10.4 3 7.3 10.4 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit GBP_C PF02841.14 CAV26073.1 - 2.8 7.3 28.9 3.4 7.0 28.9 1.1 1 0 0 1 1 1 0 Guanylate-binding protein, C-terminal domain Allexi_40kDa PF05549.11 CAV26073.1 - 6 6.3 6.5 7.6 6.0 6.5 1.1 1 0 0 1 1 1 0 Allexivirus 40kDa protein V_ATPase_I PF01496.19 CAV26073.1 - 7.6 4.3 20.4 9.4 4.0 20.4 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family ThrE PF06738.12 CAV26078.1 - 3.8e-23 82.1 31.7 2.7e-13 49.8 14.3 3.0 3 0 0 3 3 3 3 Putative threonine/serine exporter ThrE_2 PF12821.7 CAV26078.1 - 3.5e-12 46.6 28.2 5.2e-08 33.1 9.9 2.2 2 0 0 2 2 2 2 Threonine/Serine exporter, ThrE Na_Pi_cotrans PF02690.15 CAV26078.1 - 0.021 14.9 3.7 0.021 14.9 3.7 2.9 3 0 0 3 3 3 0 Na+/Pi-cotransporter DUF872 PF05915.12 CAV26078.1 - 8.6 6.6 9.5 4.6 7.4 0.4 3.3 3 1 0 3 3 3 0 Eukaryotic protein of unknown function (DUF872) PhnA PF03831.14 CAV26079.1 - 7.4e-24 83.4 6.0 8.8e-24 83.2 6.0 1.1 1 0 0 1 1 1 1 PhnA domain PhnA_Zn_Ribbon PF08274.12 CAV26079.1 - 7.8e-14 51.3 7.5 1.3e-13 50.7 7.5 1.3 1 0 0 1 1 1 1 PhnA Zinc-Ribbon TF_Zn_Ribbon PF08271.12 CAV26079.1 - 0.00066 19.1 1.2 0.0012 18.3 1.2 1.5 1 0 0 1 1 1 1 TFIIB zinc-binding FYDLN_acid PF09538.10 CAV26079.1 - 0.034 14.8 0.3 0.054 14.2 0.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (FYDLN_acid) zinc_ribbon_4 PF13717.6 CAV26079.1 - 0.055 13.4 3.2 4.5 7.3 0.9 2.5 2 0 0 2 2 2 0 zinc-ribbon domain zinc-ribbons_6 PF07191.12 CAV26079.1 - 0.078 13.0 1.2 0.13 12.3 1.2 1.4 1 0 0 1 1 1 0 zinc-ribbons RPA_interact_C PF14768.6 CAV26079.1 - 0.081 13.5 0.5 0.11 13.1 0.5 1.5 1 1 0 1 1 1 0 Replication protein A interacting C-terminal A2L_zn_ribbon PF08792.10 CAV26079.1 - 0.085 12.6 2.2 0.21 11.4 1.8 1.9 2 1 0 2 2 2 0 A2L zinc ribbon domain PADR1 PF08063.12 CAV26079.1 - 0.1 12.4 1.9 0.2 11.5 1.9 1.4 1 0 0 1 1 1 0 PADR1 (NUC008) domain DUF2318 PF10080.9 CAV26079.1 - 0.11 12.6 0.4 0.23 11.6 0.4 1.5 1 1 0 1 1 1 0 Predicted membrane protein (DUF2318) UPF0547 PF10571.9 CAV26079.1 - 0.17 12.0 6.8 0.36 10.9 0.0 2.2 2 0 0 2 2 2 0 Uncharacterised protein family UPF0547 Lar_restr_allev PF14354.6 CAV26079.1 - 0.28 11.6 3.6 0.82 10.1 3.6 1.8 1 1 0 1 1 1 0 Restriction alleviation protein Lar zf-Mss51 PF13824.6 CAV26079.1 - 0.37 10.9 3.2 0.36 11.0 1.4 1.8 2 0 0 2 2 2 0 Zinc-finger of mitochondrial splicing suppressor 51 zf-RRN7 PF11781.8 CAV26079.1 - 1.7 8.4 5.8 14 5.5 5.2 2.2 1 1 1 2 2 2 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 Zn_Tnp_IS1 PF03811.13 CAV26079.1 - 6.5 6.6 5.9 2 8.2 0.7 2.2 1 1 1 2 2 2 0 InsA N-terminal domain Acetyltransf_7 PF13508.7 CAV26081.1 - 3.1e-12 46.7 0.0 6.1e-12 45.8 0.1 1.4 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 CAV26081.1 - 8.6e-12 45.1 0.0 9.9e-12 44.9 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 CAV26081.1 - 1.2e-09 38.4 0.0 1.9e-09 37.8 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family FR47 PF08445.10 CAV26081.1 - 0.005 16.8 0.0 0.014 15.4 0.0 1.7 1 1 0 1 1 1 1 FR47-like protein Acetyltransf_CG PF14542.6 CAV26081.1 - 0.038 14.1 0.1 0.15 12.3 0.0 2.0 2 1 0 2 2 2 0 GCN5-related N-acetyl-transferase Acetyltransf_18 PF18014.1 CAV26081.1 - 0.061 13.2 0.0 0.13 12.1 0.0 1.5 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 CAV26083.1 - 5.2e-07 29.9 0.0 6.6e-07 29.6 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_3 PF13302.7 CAV26083.1 - 1.7e-06 28.7 0.0 2.2e-06 28.4 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 CAV26083.1 - 0.001 19.0 0.0 0.0016 18.4 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 CAV26083.1 - 0.0029 18.0 0.0 0.0045 17.4 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 CAV26083.1 - 0.035 14.1 0.0 0.052 13.5 0.0 1.2 1 0 0 1 1 1 0 FR47-like protein Acetyltransf_13 PF13880.6 CAV26083.1 - 0.054 13.5 0.0 0.1 12.6 0.0 1.4 1 0 0 1 1 1 0 ESCO1/2 acetyl-transferase Acetyltransf_7 PF13508.7 CAV26085.1 - 3.8e-09 36.8 0.1 7.3e-09 35.9 0.1 1.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 CAV26085.1 - 5.5e-07 29.6 0.0 1e-06 28.7 0.0 1.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 CAV26085.1 - 9.7e-07 29.0 0.0 1.3e-06 28.7 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_3 PF13302.7 CAV26085.1 - 0.02 15.6 0.0 0.024 15.3 0.0 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain HTH_18 PF12833.7 CAV26087.1 - 1.6e-20 73.1 0.1 4.3e-20 71.8 0.1 1.7 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_AraC PF00165.23 CAV26087.1 - 4.9e-15 55.2 0.6 3.2e-06 27.1 0.1 2.8 3 0 0 3 3 3 2 Bacterial regulatory helix-turn-helix proteins, AraC family FtsK_gamma PF09397.10 CAV26087.1 - 0.11 12.3 0.1 0.42 10.5 0.1 2.0 1 0 0 1 1 1 0 Ftsk gamma domain Matrilin_ccoil PF10393.9 CAV26087.1 - 1.1 9.1 7.5 0.33 10.8 1.0 2.9 3 0 0 3 3 3 0 Trimeric coiled-coil oligomerisation domain of matrilin TonB_dep_Rec PF00593.24 CAV26089.1 - 1.2e-38 134.3 31.4 1.2e-38 134.3 31.4 1.7 1 1 1 2 2 2 1 TonB dependent receptor Plug PF07715.15 CAV26089.1 - 7.3e-13 49.0 2.7 2e-12 47.6 0.7 2.6 2 0 0 2 2 2 1 TonB-dependent Receptor Plug Domain ADP_ribosyl_GH PF03747.14 CAV26090.1 - 3.3e-49 168.2 0.4 3.7e-49 168.0 0.4 1.0 1 0 0 1 1 1 1 ADP-ribosylglycohydrolase BPD_transp_1 PF00528.22 CAV26091.1 - 7.1e-17 61.7 10.6 7.1e-17 61.7 10.6 2.0 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component SBP_bac_3 PF00497.20 CAV26093.1 - 2.7e-51 174.2 0.1 3.1e-51 173.9 0.1 1.0 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 Lig_chan-Glu_bd PF10613.9 CAV26093.1 - 3.4e-10 40.1 0.0 6.2e-09 36.1 0.0 2.2 1 1 0 1 1 1 1 Ligated ion channel L-glutamate- and glycine-binding site BPD_transp_1 PF00528.22 CAV26094.1 - 6.6e-20 71.6 10.6 6.6e-20 71.6 10.6 1.8 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component ABC_tran PF00005.27 CAV26096.1 - 2.5e-33 115.5 0.0 3.6e-33 115.0 0.0 1.2 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 CAV26096.1 - 1.1e-12 48.4 0.1 1.1e-06 28.7 0.1 2.2 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 CAV26096.1 - 1.9e-07 30.8 0.0 7.2e-07 28.9 0.0 1.8 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain ABC_ATPase PF09818.9 CAV26096.1 - 6.4e-06 25.2 0.0 0.13 11.0 0.0 2.9 2 1 0 2 2 2 2 Predicted ATPase of the ABC class AAA_29 PF13555.6 CAV26096.1 - 1.3e-05 24.8 0.0 2.5e-05 23.9 0.0 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_23 PF13476.6 CAV26096.1 - 2.7e-05 24.8 0.4 5.2e-05 23.8 0.0 1.6 2 0 0 2 2 1 1 AAA domain AAA_22 PF13401.6 CAV26096.1 - 3e-05 24.3 0.3 0.0002 21.7 0.3 2.3 1 1 0 1 1 1 1 AAA domain RsgA_GTPase PF03193.16 CAV26096.1 - 0.0001 22.2 0.0 0.00032 20.6 0.0 1.8 2 0 0 2 2 2 1 RsgA GTPase AAA_15 PF13175.6 CAV26096.1 - 0.00013 21.8 0.1 0.016 15.0 0.0 2.1 1 1 0 2 2 2 1 AAA ATPase domain AAA_16 PF13191.6 CAV26096.1 - 0.00025 21.5 0.0 0.00042 20.7 0.0 1.7 1 1 0 1 1 1 1 AAA ATPase domain AAA_13 PF13166.6 CAV26096.1 - 0.00043 19.1 0.0 0.47 9.0 0.0 2.1 1 1 1 2 2 2 2 AAA domain Rad17 PF03215.15 CAV26096.1 - 0.00081 19.4 0.0 0.0013 18.7 0.0 1.5 1 0 0 1 1 1 1 Rad17 P-loop domain ATPase_2 PF01637.18 CAV26096.1 - 0.0031 17.5 0.0 0.0077 16.2 0.0 1.6 2 0 0 2 2 1 1 ATPase domain predominantly from Archaea Mg_chelatase PF01078.21 CAV26096.1 - 0.005 16.3 0.1 0.081 12.3 0.0 2.2 1 1 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_33 PF13671.6 CAV26096.1 - 0.0055 16.9 0.0 0.0085 16.3 0.0 1.6 1 1 0 1 1 1 1 AAA domain AAA PF00004.29 CAV26096.1 - 0.017 15.6 0.2 4.6 7.7 0.0 2.9 2 1 1 3 3 3 0 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.6 CAV26096.1 - 0.018 15.6 0.0 0.032 14.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain T2SSE PF00437.20 CAV26096.1 - 0.021 13.9 0.0 0.048 12.7 0.0 1.6 2 0 0 2 2 2 0 Type II/IV secretion system protein AAA_27 PF13514.6 CAV26096.1 - 0.024 14.3 0.0 0.045 13.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain SbcCD_C PF13558.6 CAV26096.1 - 0.024 14.9 0.3 0.3 11.3 0.3 2.6 2 1 0 2 2 2 0 Putative exonuclease SbcCD, C subunit AAA_30 PF13604.6 CAV26096.1 - 0.029 14.1 0.0 0.23 11.2 0.0 2.3 2 1 0 2 2 2 0 AAA domain IstB_IS21 PF01695.17 CAV26096.1 - 0.048 13.4 0.0 0.19 11.5 0.0 1.9 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA_19 PF13245.6 CAV26096.1 - 0.052 13.9 0.2 1.2 9.5 0.0 2.4 2 1 0 2 2 2 0 AAA domain NB-ARC PF00931.22 CAV26096.1 - 0.069 12.3 0.0 0.11 11.7 0.0 1.4 1 1 0 1 1 1 0 NB-ARC domain Adeno_IVa2 PF02456.15 CAV26096.1 - 0.075 11.8 0.0 0.12 11.1 0.0 1.3 1 0 0 1 1 1 0 Adenovirus IVa2 protein RNA_helicase PF00910.22 CAV26096.1 - 0.096 13.1 0.0 0.65 10.4 0.0 2.1 2 0 0 2 2 2 0 RNA helicase AAA_24 PF13479.6 CAV26096.1 - 0.15 11.8 0.0 0.68 9.6 0.0 1.9 2 0 0 2 2 2 0 AAA domain Fe-ADH PF00465.19 CAV26098.1 - 4e-77 259.5 1.8 4.8e-77 259.2 1.8 1.0 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase Fe-ADH_2 PF13685.6 CAV26098.1 - 5.7e-14 52.4 0.9 2.4e-08 34.0 0.5 2.3 2 0 0 2 2 2 2 Iron-containing alcohol dehydrogenase DHQ_synthase PF01761.20 CAV26098.1 - 0.00023 20.4 0.5 0.71 9.0 0.1 2.8 3 1 0 3 3 3 2 3-dehydroquinate synthase Glyco_tran_WecB PF03808.13 CAV26098.1 - 0.04 13.9 0.2 2.1 8.2 0.0 2.3 2 0 0 2 2 2 0 Glycosyl transferase WecB/TagA/CpsF family AraC_N PF06719.13 CAV26099.1 - 5e-34 117.1 0.0 6.8e-34 116.6 0.0 1.2 1 0 0 1 1 1 1 AraC-type transcriptional regulator N-terminus HTH_18 PF12833.7 CAV26099.1 - 1.8e-20 73.0 0.3 3.4e-20 72.1 0.3 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 CAV26099.1 - 4.7e-17 61.6 0.1 2.8e-08 33.7 0.0 2.5 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family MarR_2 PF12802.7 CAV26099.1 - 7.8e-06 25.7 0.0 0.2 11.6 0.0 3.3 3 0 0 3 3 3 2 MarR family HTH_24 PF13412.6 CAV26099.1 - 0.0041 16.6 0.0 2.7 7.6 0.0 3.0 3 0 0 3 3 3 2 Winged helix-turn-helix DNA-binding MarR PF01047.22 CAV26099.1 - 0.021 14.8 0.0 2.1 8.4 0.0 3.2 2 1 0 2 2 2 0 MarR family TetR_N PF00440.23 CAV26099.1 - 0.034 13.9 0.0 1.3 8.8 0.0 2.4 2 0 0 2 2 2 0 Bacterial regulatory proteins, tetR family Ribonuc_L-PSP PF01042.21 CAV26101.1 - 3.3e-76 253.1 11.7 1.2e-27 96.3 0.4 3.1 3 0 0 3 3 3 3 Endoribonuclease L-PSP QRPTase_C PF01729.19 CAV26101.1 - 0.00077 19.3 4.8 0.77 9.5 0.1 3.2 3 0 0 3 3 3 2 Quinolinate phosphoribosyl transferase, C-terminal domain DHquinase_I PF01487.15 CAV26101.1 - 0.00092 19.5 1.2 1.2 9.3 0.1 3.1 3 0 0 3 3 3 1 Type I 3-dehydroquinase AA_synth PF06684.11 CAV26101.1 - 0.0018 17.8 0.5 1.3 8.6 0.0 3.8 2 2 2 4 4 4 1 Amino acid synthesis DUF3870 PF12986.7 CAV26101.1 - 0.0049 17.1 3.1 1.7 8.9 0.1 3.3 4 0 0 4 4 3 2 Domain of unknown function (DUF3870) NTP_transf_5 PF14907.6 CAV26101.1 - 0.0055 16.4 0.0 0.73 9.4 0.0 2.8 3 0 0 3 3 3 1 Uncharacterised nucleotidyltransferase T4SS_CagC PF16943.5 CAV26101.1 - 0.01 16.0 3.7 9.8 6.4 0.1 3.2 3 0 0 3 3 3 0 Cag pathogenicity island, type IV secretory system ApoLp-III PF07464.11 CAV26101.1 - 0.011 15.9 4.9 0.58 10.2 0.1 3.1 3 0 0 3 3 3 0 Apolipophorin-III precursor (apoLp-III) DUF948 PF06103.11 CAV26101.1 - 0.014 15.6 9.7 3.4 8.0 0.1 3.5 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF948) GEP5 PF17053.5 CAV26101.1 - 0.035 13.9 0.0 10 5.9 0.0 2.9 3 0 0 3 3 3 0 Genetic interactor of prohibitin 5 DUF148 PF02520.17 CAV26101.1 - 0.18 11.9 5.3 6.7 6.9 0.1 3.5 3 1 0 3 3 3 0 Domain of unknown function DUF148 DDR PF08841.10 CAV26101.1 - 0.19 10.7 6.6 1.1 8.2 0.3 2.9 3 0 0 3 3 3 0 Diol dehydratase reactivase ATPase-like domain CC2-LZ PF16516.5 CAV26101.1 - 0.21 12.0 0.0 3.9 7.9 0.0 2.2 2 0 0 2 2 2 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator DUF3764 PF12594.8 CAV26101.1 - 0.22 11.6 1.9 10 6.2 0.1 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF3764) NPV_P10 PF05531.12 CAV26101.1 - 6.1 7.4 7.9 57 4.3 0.6 3.5 3 0 0 3 3 3 0 Nucleopolyhedrovirus P10 protein Clat_adaptor_s PF01217.20 CAV26101.1 - 6.3 6.7 7.8 2.7 7.9 1.0 2.8 3 0 0 3 3 3 0 Clathrin adaptor complex small chain EAL PF00563.20 CAV26106.1 - 9.4e-54 182.4 0.0 1.4e-53 181.9 0.0 1.3 1 0 0 1 1 1 1 EAL domain DUF2572 PF10833.8 CAV26106.1 - 0.066 13.0 0.9 0.14 11.9 0.9 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2572) Lipase_GDSL PF00657.22 CAV26108.1 - 0.01 15.8 1.3 0.017 15.1 1.3 1.4 1 0 0 1 1 1 0 GDSL-like Lipase/Acylhydrolase Leader_CPA1 PF08252.11 CAV26108.1 - 0.079 12.4 0.1 0.22 11.0 0.1 1.7 1 0 0 1 1 1 0 arg-2/CPA1 leader peptide Acetyltransf_3 PF13302.7 CAV26110.1 - 8.4e-17 62.1 0.0 9.7e-17 61.9 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 CAV26110.1 - 8.7e-05 22.7 0.0 0.0001 22.5 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 CAV26110.1 - 0.00066 19.9 0.0 0.0009 19.5 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family DUF417 PF04224.12 CAV26112.1 - 4.2e-42 143.6 9.6 2.1e-40 138.1 9.6 2.0 1 1 0 1 1 1 1 Protein of unknown function, DUF417 Ribonuc_L-PSP PF01042.21 CAV26114.1 - 7.5e-18 64.7 0.1 8.9e-18 64.5 0.1 1.2 1 0 0 1 1 1 1 Endoribonuclease L-PSP Arcadin_1 PF18653.1 CAV26114.1 - 0.057 13.5 0.0 0.081 13.0 0.0 1.2 1 0 0 1 1 1 0 Arcadin 1 YojJ PF10372.9 CAV26114.1 - 0.14 12.3 0.0 0.21 11.7 0.0 1.3 1 0 0 1 1 1 0 Bacterial membrane-spanning protein N-terminus BCCT PF02028.17 CAV26116.1 - 2.5e-145 484.6 47.0 3e-145 484.4 47.0 1.0 1 0 0 1 1 1 1 BCCT, betaine/carnitine/choline family transporter Glyco_hydro_18 PF00704.28 CAV26117.1 - 2.7e-86 290.2 6.2 4.6e-86 289.4 6.2 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 ChiC PF06483.11 CAV26117.1 - 9.3e-72 240.6 0.7 2.1e-71 239.4 0.7 1.6 1 0 0 1 1 1 1 Chitinase C Big_7 PF17957.1 CAV26117.1 - 7.4e-26 90.7 22.0 8.8e-14 52.0 5.9 3.7 2 0 0 2 2 2 2 Bacterial Ig domain CBM_5_12_2 PF14600.6 CAV26117.1 - 3.9e-19 68.3 13.5 3.1e-18 65.5 5.2 3.0 2 0 0 2 2 2 2 Cellulose-binding domain CBM_5_12 PF02839.14 CAV26117.1 - 2.5e-06 27.8 18.9 0.0053 17.3 5.8 4.2 3 0 0 3 3 3 2 Carbohydrate binding domain BiPBP_C PF06832.12 CAV26117.1 - 0.0015 18.6 0.0 0.039 14.0 0.0 2.8 3 0 0 3 3 3 1 Penicillin-Binding Protein C-terminus Family TORC_M PF12885.7 CAV26117.1 - 0.057 13.3 0.2 0.93 9.4 0.1 2.8 3 0 0 3 3 3 0 Transducer of regulated CREB activity middle domain Lipoprotein_21 PF14041.6 CAV26117.1 - 0.084 13.0 2.0 13 6.0 0.2 2.6 2 0 0 2 2 2 0 LppP/LprE lipoprotein GGDEF PF00990.21 CAV26119.1 - 3.3e-35 121.2 0.0 7e-35 120.2 0.0 1.6 1 0 0 1 1 1 1 Diguanylate cyclase, GGDEF domain dCache_2 PF08269.11 CAV26119.1 - 4.4e-20 72.1 0.2 6.5e-20 71.5 0.2 1.2 1 0 0 1 1 1 1 Cache domain Cache_3-Cache_2 PF17201.4 CAV26119.1 - 1.3e-19 70.5 0.0 1e-10 41.4 0.0 2.2 1 1 1 2 2 2 2 Cache 3/Cache 2 fusion domain sCache_2 PF17200.4 CAV26119.1 - 5.3e-15 55.6 0.2 3.6e-06 26.9 0.0 2.5 2 1 0 2 2 2 2 Single Cache domain 2 dCache_1 PF02743.18 CAV26119.1 - 1.4e-09 38.1 0.4 2.4e-05 24.2 0.1 3.0 2 1 1 3 3 3 2 Cache domain DUF3290 PF11694.8 CAV26119.1 - 0.43 10.6 3.9 3.2 7.7 0.4 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3290) Imp-YgjV PF10688.9 CAV26121.1 - 4.4e-08 33.1 1.9 5.1e-08 32.9 1.9 1.0 1 0 0 1 1 1 1 Bacterial inner membrane protein MtN3_slv PF03083.16 CAV26121.1 - 0.085 12.9 2.3 0.13 12.4 2.2 1.6 1 1 0 1 1 1 0 Sugar efflux transporter for intercellular exchange DUF4136 PF13590.6 CAV26123.1 - 1.4e-10 41.9 0.0 1.7e-10 41.6 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4136) Peptidase_S11 PF00768.20 CAV26124.1 - 6.8e-85 284.4 0.1 9.2e-85 283.9 0.1 1.1 1 0 0 1 1 1 1 D-alanyl-D-alanine carboxypeptidase PBP5_C PF07943.13 CAV26124.1 - 6.2e-22 77.6 0.1 1.1e-21 76.8 0.1 1.5 1 0 0 1 1 1 1 Penicillin-binding protein 5, C-terminal domain Beta-lactamase2 PF13354.6 CAV26124.1 - 2.1e-07 30.8 0.1 3.3e-07 30.1 0.1 1.3 1 0 0 1 1 1 1 Beta-lactamase enzyme family Peptidase_S13 PF02113.15 CAV26124.1 - 0.0031 16.3 0.0 0.0049 15.6 0.0 1.2 1 0 0 1 1 1 1 D-Ala-D-Ala carboxypeptidase 3 (S13) family Beta-lactamase PF00144.24 CAV26124.1 - 0.022 14.0 0.0 0.083 12.1 0.0 1.8 2 1 0 2 2 2 0 Beta-lactamase DUF1899 PF08953.11 CAV26124.1 - 0.065 13.1 0.0 0.15 11.9 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF1899) CxxCxxCC PF03692.15 CAV26125.1 - 9.7e-10 39.0 5.7 1.5e-09 38.4 5.7 1.2 1 0 0 1 1 1 1 Putative zinc- or iron-chelating domain LysR_substrate PF03466.20 CAV26127.1 - 1.6e-44 151.8 0.0 1.9e-44 151.6 0.0 1.1 1 0 0 1 1 1 1 LysR substrate binding domain HTH_1 PF00126.27 CAV26127.1 - 1.8e-17 63.0 0.0 3.1e-17 62.3 0.0 1.4 1 0 0 1 1 1 1 Bacterial regulatory helix-turn-helix protein, lysR family DoxX_2 PF13564.6 CAV26129.1 - 9.4e-19 67.4 7.1 1.1e-18 67.2 7.1 1.1 1 0 0 1 1 1 1 DoxX-like family PseudoU_synth_2 PF00849.22 CAV26131.1 - 1.4e-27 96.8 0.0 3.1e-27 95.6 0.0 1.6 1 0 0 1 1 1 1 RNA pseudouridylate synthase GST_N PF02798.20 CAV26132.1 - 1.8e-16 60.2 0.0 3.1e-16 59.5 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 CAV26132.1 - 3.5e-13 49.8 0.0 1.1e-12 48.2 0.0 1.7 1 1 1 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 CAV26132.1 - 1.2e-10 41.6 0.0 2.5e-10 40.5 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 CAV26132.1 - 2.4e-07 30.9 0.0 4e-07 30.2 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 CAV26132.1 - 5.5e-05 23.3 0.0 9.1e-05 22.6 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_4 PF17172.4 CAV26132.1 - 0.034 14.9 0.0 0.19 12.5 0.0 2.2 1 1 1 2 2 2 0 Glutathione S-transferase N-terminal domain ADH_N_2 PF16884.5 CAV26134.1 - 6.2e-42 141.9 0.0 1.1e-41 141.0 0.0 1.5 1 0 0 1 1 1 1 N-terminal domain of oxidoreductase ADH_zinc_N PF00107.26 CAV26134.1 - 1.5e-21 76.7 0.1 2.4e-21 76.1 0.1 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 CAV26134.1 - 1.3e-12 49.0 0.0 2e-12 48.3 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase TetR_N PF00440.23 CAV26136.1 - 1.4e-11 44.0 0.0 2.6e-11 43.1 0.0 1.5 1 0 0 1 1 1 1 Bacterial regulatory proteins, tetR family TetR_C_13 PF16925.5 CAV26136.1 - 3.1e-08 33.6 0.0 6.5e-08 32.5 0.0 1.6 1 1 1 2 2 2 1 Tetracyclin repressor-like, C-terminal domain TetR_C_24 PF17932.1 CAV26136.1 - 0.042 14.1 0.0 0.082 13.2 0.0 1.4 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain FKBP_C PF00254.28 CAV26138.1 - 3.6e-28 97.7 0.0 8.9e-28 96.5 0.0 1.6 2 0 0 2 2 2 1 FKBP-type peptidyl-prolyl cis-trans isomerase FKBP_N PF01346.18 CAV26138.1 - 4.1e-10 40.5 0.1 1e-09 39.2 0.0 1.6 2 0 0 2 2 2 1 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase DUF4827 PF16109.5 CAV26138.1 - 0.0042 17.1 0.0 0.015 15.3 0.0 1.8 1 1 0 1 1 1 1 Domain of unknown function (DUF4827) FeoB_associated PF12669.7 CAV26138.1 - 0.0094 16.3 0.0 0.015 15.7 0.0 1.3 1 0 0 1 1 1 1 FeoB-associated Cys-rich membrane protein TNFR_16_TM PF18422.1 CAV26138.1 - 0.085 12.8 0.0 0.15 12.1 0.0 1.3 1 0 0 1 1 1 0 Tumor necrosis factor receptor member 16 trans-membrane domain Thioredoxin_4 PF13462.6 CAV26139.1 - 4.9e-07 30.1 0.2 7.9e-07 29.4 0.2 1.3 1 0 0 1 1 1 1 Thioredoxin DSBA PF01323.20 CAV26139.1 - 5.6e-05 23.0 0.5 0.071 12.9 0.5 2.2 1 1 1 2 2 2 2 DSBA-like thioredoxin domain Thioredoxin_3 PF13192.6 CAV26139.1 - 0.00023 21.1 0.1 0.2 11.7 0.0 2.4 2 0 0 2 2 2 2 Thioredoxin domain Thioredoxin PF00085.20 CAV26139.1 - 0.0004 20.3 0.1 0.095 12.7 0.0 2.3 2 0 0 2 2 2 2 Thioredoxin Thioredoxin_2 PF13098.6 CAV26139.1 - 0.02 15.3 0.1 0.091 13.2 0.1 1.9 1 1 0 1 1 1 0 Thioredoxin-like domain DUF5464 PF17552.2 CAV26139.1 - 0.12 12.7 0.4 0.24 11.7 0.4 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5464) Paf1 PF03985.13 CAV26139.1 - 0.15 11.0 0.1 0.21 10.5 0.1 1.2 1 0 0 1 1 1 0 Paf1 OmpA PF00691.20 CAV26143.1 - 2.3e-16 60.0 0.0 3e-16 59.6 0.0 1.2 1 0 0 1 1 1 1 OmpA family GST_N_3 PF13417.6 CAV26145.1 - 2.8e-12 46.9 0.0 4.2e-12 46.3 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain Glutaredoxin PF00462.24 CAV26145.1 - 1.3e-11 44.6 0.0 2.3e-11 43.7 0.0 1.4 1 0 0 1 1 1 1 Glutaredoxin GST_N_2 PF13409.6 CAV26145.1 - 2.5e-07 30.9 0.0 3.7e-07 30.3 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain Sigma54_activat PF00158.26 CAV26146.1 - 4.8e-67 224.8 0.0 7.8e-67 224.2 0.0 1.3 1 0 0 1 1 1 1 Sigma-54 interaction domain Sigma54_activ_2 PF14532.6 CAV26146.1 - 3.5e-24 85.5 0.0 7.9e-24 84.3 0.0 1.7 1 0 0 1 1 1 1 Sigma-54 interaction domain AAA_5 PF07728.14 CAV26146.1 - 1.3e-07 31.7 0.0 2.2e-07 31.0 0.0 1.4 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) GAF PF01590.26 CAV26146.1 - 7.6e-07 29.8 0.0 2.4e-06 28.2 0.0 1.8 2 0 0 2 2 1 1 GAF domain AAA PF00004.29 CAV26146.1 - 3.3e-06 27.5 0.0 9.2e-06 26.1 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) GAF_2 PF13185.6 CAV26146.1 - 4.7e-06 27.0 0.0 9.9e-06 25.9 0.0 1.5 1 0 0 1 1 1 1 GAF domain Mg_chelatase PF01078.21 CAV26146.1 - 4.5e-05 22.9 0.0 0.07 12.5 0.0 2.3 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_22 PF13401.6 CAV26146.1 - 0.0018 18.6 0.0 0.0086 16.4 0.0 2.2 1 1 0 1 1 1 1 AAA domain TilS_C PF11734.8 CAV26146.1 - 0.006 16.0 0.0 0.055 12.9 0.0 2.3 2 0 0 2 2 2 1 TilS substrate C-terminal domain AAA_2 PF07724.14 CAV26146.1 - 0.0097 16.0 0.0 0.02 15.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_16 PF13191.6 CAV26146.1 - 0.015 15.7 0.2 0.046 14.1 0.0 2.0 2 1 0 2 2 2 0 AAA ATPase domain IstB_IS21 PF01695.17 CAV26146.1 - 0.018 14.8 0.0 0.043 13.5 0.0 1.6 1 0 0 1 1 1 0 IstB-like ATP binding protein MCM PF00493.23 CAV26146.1 - 0.021 13.9 0.0 0.12 11.4 0.0 2.1 2 1 0 2 2 2 0 MCM P-loop domain HTH_8 PF02954.19 CAV26146.1 - 0.074 12.8 0.4 0.41 10.5 0.0 2.5 2 1 0 2 2 2 0 Bacterial regulatory protein, Fis family Globin PF00042.22 CAV26148.1 - 3.7e-13 50.0 0.1 6.1e-13 49.3 0.1 1.4 1 0 0 1 1 1 1 Globin NAD_binding_1 PF00175.21 CAV26148.1 - 6e-13 49.4 0.4 2.7e-12 47.3 0.0 2.2 3 0 0 3 3 3 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.24 CAV26148.1 - 2.6e-09 37.3 0.0 4.6e-09 36.5 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain Protoglobin PF11563.8 CAV26148.1 - 7.5e-05 22.7 0.2 0.00013 21.9 0.2 1.4 1 0 0 1 1 1 1 Protoglobin NAD_binding_6 PF08030.12 CAV26148.1 - 0.0053 16.9 0.0 0.05 13.7 0.0 2.5 2 1 1 3 3 3 1 Ferric reductase NAD binding domain Endonuc-BglII PF09195.11 CAV26148.1 - 0.067 13.0 0.2 15 5.4 0.1 2.4 1 1 1 2 2 2 0 Restriction endonuclease BglII SLAC1 PF03595.17 CAV26150.1 - 1.3e-27 97.0 34.2 1.5e-27 96.8 34.2 1.0 1 0 0 1 1 1 1 Voltage-dependent anion channel Voltage_CLC PF00654.20 CAV26152.1 - 1.3e-98 330.6 31.0 2.4e-96 323.1 26.4 2.0 1 1 1 2 2 2 2 Voltage gated chloride channel Abhydrolase_9_N PF15420.6 CAV26152.1 - 0.0084 16.1 5.1 0.55 10.2 0.0 3.0 3 0 0 3 3 3 2 Alpha/beta-hydrolase family N-terminus Ytca PF17090.5 CAV26152.1 - 0.017 15.6 0.4 0.1 13.1 0.1 2.4 2 0 0 2 2 2 0 Uncharacterised protein family MitoNEET_N PF10660.9 CAV26152.1 - 0.27 11.3 2.0 0.43 10.6 0.4 2.2 2 0 0 2 2 2 0 Iron-containing outer mitochondrial membrane protein N-terminus cobW PF02492.19 CAV26153.1 - 4.4e-42 143.7 0.0 7.5e-42 142.9 0.0 1.4 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain T2SSE PF00437.20 CAV26153.1 - 0.00041 19.5 0.0 0.00069 18.8 0.0 1.3 1 0 0 1 1 1 1 Type II/IV secretion system protein CobW_C PF07683.14 CAV26153.1 - 0.0027 17.6 0.0 0.0076 16.1 0.0 1.8 2 0 0 2 2 2 1 Cobalamin synthesis protein cobW C-terminal domain AAA_22 PF13401.6 CAV26153.1 - 0.076 13.3 0.0 0.19 12.0 0.0 1.9 1 1 0 1 1 1 0 AAA domain Viral_helicase1 PF01443.18 CAV26153.1 - 0.12 12.1 0.0 0.19 11.5 0.0 1.3 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase DEAD PF00270.29 CAV26155.1 - 4.1e-51 173.2 1.9 6.2e-50 169.4 0.2 2.4 3 0 0 3 3 3 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CAV26155.1 - 8e-30 103.4 1.5 1.2e-28 99.7 0.0 3.1 4 0 0 4 4 4 1 Helicase conserved C-terminal domain ResIII PF04851.15 CAV26155.1 - 3.6e-11 43.4 0.8 2.3e-10 40.8 0.0 2.2 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_19 PF13245.6 CAV26155.1 - 0.0061 16.9 1.4 0.031 14.6 1.4 2.1 1 1 0 1 1 1 1 AAA domain Terminase_6 PF03237.15 CAV26155.1 - 0.021 14.5 0.0 0.12 12.0 0.0 2.1 2 1 0 2 2 2 0 Terminase-like family Hydrolase PF00702.26 CAV26155.1 - 0.035 14.4 0.1 0.09 13.0 0.1 1.5 1 1 0 1 1 1 0 haloacid dehalogenase-like hydrolase Flavi_DEAD PF07652.14 CAV26155.1 - 0.038 14.0 0.0 0.087 12.8 0.0 1.8 1 1 0 1 1 1 0 Flavivirus DEAD domain AAA_22 PF13401.6 CAV26155.1 - 0.3 11.4 1.7 4 7.7 1.7 2.5 1 1 0 1 1 1 0 AAA domain LysE PF01810.18 CAV26156.1 - 4.5e-22 78.4 9.9 4.9e-22 78.3 9.9 1.0 1 0 0 1 1 1 1 LysE type translocator TerC PF03741.16 CAV26156.1 - 0.02 14.6 0.8 0.02 14.6 0.8 1.8 1 1 2 3 3 3 0 Integral membrane protein TerC family DUF839 PF05787.13 CAV26158.1 - 3.1e-156 521.6 3.1 3.7e-156 521.3 3.1 1.0 1 0 0 1 1 1 1 Bacterial protein of unknown function (DUF839) TAT_signal PF10518.9 CAV26158.1 - 0.00031 20.5 2.0 0.00066 19.4 2.0 1.6 1 0 0 1 1 1 1 TAT (twin-arginine translocation) pathway signal sequence DUF469 PF04320.14 CAV26160.1 - 1.4e-33 115.7 0.1 1.6e-33 115.5 0.1 1.0 1 0 0 1 1 1 1 Protein with unknown function (DUF469) Spond_N PF06468.13 CAV26163.1 - 1.2e-09 38.6 0.0 1.7e-09 38.1 0.0 1.2 1 0 0 1 1 1 1 Spondin_N Spond_N PF06468.13 CAV26165.1 - 1.2e-10 41.9 0.0 1.6e-10 41.4 0.0 1.1 1 0 0 1 1 1 1 Spondin_N CBM49 PF09478.10 CAV26165.1 - 0.11 12.9 0.0 6.4 7.2 0.0 2.2 2 0 0 2 2 2 0 Carbohydrate binding domain CBM49 LPAM_1 PF08139.12 CAV26165.1 - 0.28 11.8 1.6 0.9 10.2 1.6 1.9 1 0 0 1 1 1 0 Prokaryotic membrane lipoprotein lipid attachment site Trans_reg_C PF00486.28 CAV26167.1 - 2.1e-23 82.2 0.0 3.8e-23 81.4 0.0 1.4 1 0 0 1 1 1 1 Transcriptional regulatory protein, C terminal Response_reg PF00072.24 CAV26167.1 - 1.2e-22 80.2 0.1 1.8e-22 79.7 0.1 1.2 1 0 0 1 1 1 1 Response regulator receiver domain FleQ PF06490.11 CAV26167.1 - 0.0014 18.9 0.0 0.0028 18.0 0.0 1.5 1 0 0 1 1 1 1 Flagellar regulatory protein FleQ MarR_2 PF12802.7 CAV26167.1 - 0.15 12.0 0.0 0.4 10.6 0.0 1.8 1 0 0 1 1 1 0 MarR family HisKA PF00512.25 CAV26169.1 - 5.7e-09 35.9 0.2 1.7e-08 34.3 0.0 2.0 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain HATPase_c PF02518.26 CAV26169.1 - 0.0085 16.6 0.0 0.022 15.3 0.0 1.7 1 1 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_5 PF14501.6 CAV26169.1 - 0.01 15.7 0.0 0.042 13.8 0.0 2.1 1 1 0 1 1 1 0 GHKL domain EamA PF00892.20 CAV26173.1 - 1.2e-19 70.9 33.8 4.1e-10 40.0 13.9 2.1 2 0 0 2 2 2 2 EamA-like transporter family Multi_Drug_Res PF00893.19 CAV26173.1 - 0.018 15.7 0.2 0.018 15.7 0.2 2.9 3 1 0 3 3 3 0 Small Multidrug Resistance protein DUF373 PF04123.13 CAV26173.1 - 0.025 14.0 4.7 0.041 13.3 4.7 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF373) HTH_24 PF13412.6 CAV26177.1 - 9.9e-21 73.1 0.3 1.5e-20 72.4 0.3 1.3 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding AsnC_trans_reg PF01037.21 CAV26177.1 - 1.3e-20 73.2 0.4 1.9e-20 72.6 0.4 1.3 1 0 0 1 1 1 1 Lrp/AsnC ligand binding domain HTH_AsnC-type PF13404.6 CAV26177.1 - 4.4e-19 68.0 2.0 4.4e-19 68.0 2.0 1.6 2 0 0 2 2 1 1 AsnC-type helix-turn-helix domain MarR_2 PF12802.7 CAV26177.1 - 2.3e-06 27.4 0.2 4.2e-06 26.5 0.2 1.4 1 0 0 1 1 1 1 MarR family MarR PF01047.22 CAV26177.1 - 1.4e-05 24.9 0.0 3e-05 23.9 0.0 1.5 1 0 0 1 1 1 1 MarR family HTH_20 PF12840.7 CAV26177.1 - 1.5e-05 24.9 0.2 2.5e-05 24.3 0.2 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_11 PF08279.12 CAV26177.1 - 1.6e-05 24.7 0.1 3.2e-05 23.8 0.1 1.5 1 0 0 1 1 1 1 HTH domain HTH_Crp_2 PF13545.6 CAV26177.1 - 3.4e-05 23.7 0.5 0.00011 22.2 0.2 1.9 2 0 0 2 2 2 1 Crp-like helix-turn-helix domain HTH_CodY PF08222.11 CAV26177.1 - 0.00013 21.4 0.4 0.0012 18.4 0.1 2.2 1 1 1 2 2 2 1 CodY helix-turn-helix domain LexA_DNA_bind PF01726.16 CAV26177.1 - 0.00031 20.5 0.1 0.00078 19.2 0.0 1.8 2 0 0 2 2 2 1 LexA DNA binding domain HTH_39 PF14090.6 CAV26177.1 - 0.00054 19.7 0.1 0.0012 18.5 0.1 1.6 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_DeoR PF08220.12 CAV26177.1 - 0.0028 17.3 0.1 0.0085 15.8 0.0 1.8 2 0 0 2 2 2 1 DeoR-like helix-turn-helix domain TrmB PF01978.19 CAV26177.1 - 0.0031 17.4 0.0 0.0072 16.2 0.0 1.6 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB HTH_5 PF01022.20 CAV26177.1 - 0.0056 16.5 0.1 0.012 15.5 0.1 1.5 1 0 0 1 1 1 1 Bacterial regulatory protein, arsR family HTH_27 PF13463.6 CAV26177.1 - 0.0067 16.9 0.2 0.014 15.9 0.1 1.6 2 0 0 2 2 1 1 Winged helix DNA-binding domain HTH_IclR PF09339.10 CAV26177.1 - 0.0078 16.0 0.1 0.02 14.7 0.1 1.6 2 0 0 2 2 2 1 IclR helix-turn-helix domain HTH_28 PF13518.6 CAV26177.1 - 0.011 15.9 0.0 0.017 15.3 0.0 1.3 1 0 0 1 1 1 0 Helix-turn-helix domain PheRS_DBD1 PF18552.1 CAV26177.1 - 0.013 15.3 0.2 0.043 13.6 0.2 2.0 1 1 0 1 1 1 0 PheRS DNA binding domain 1 Rrf2 PF02082.20 CAV26177.1 - 0.017 15.4 0.0 0.053 13.9 0.0 1.7 2 0 0 2 2 2 0 Transcriptional regulator GntR PF00392.21 CAV26177.1 - 0.029 14.0 0.1 0.051 13.2 0.1 1.4 1 0 0 1 1 1 0 Bacterial regulatory proteins, gntR family DUF150 PF02576.17 CAV26177.1 - 0.031 14.7 0.6 0.059 13.8 0.6 1.4 1 0 0 1 1 1 0 RimP N-terminal domain HTH_29 PF13551.6 CAV26177.1 - 0.045 13.8 0.1 0.066 13.2 0.1 1.3 1 0 0 1 1 1 0 Winged helix-turn helix Mga PF05043.13 CAV26177.1 - 0.09 13.4 0.0 0.27 11.9 0.0 1.7 2 0 0 2 2 1 0 Mga helix-turn-helix domain HTH_36 PF13730.6 CAV26177.1 - 0.12 12.4 0.0 0.2 11.7 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain KxDL PF10241.9 CAV26181.1 - 0.34 11.2 9.2 0.17 12.2 1.6 3.1 1 1 2 3 3 3 0 Uncharacterized conserved protein SH3_3 PF08239.11 CAV26183.1 - 3.6e-05 23.9 0.5 7.7e-05 22.9 0.1 1.8 2 0 0 2 2 2 1 Bacterial SH3 domain DUF4366 PF14283.6 CAV26183.1 - 0.058 13.4 0.3 0.058 13.4 0.3 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4366) adh_short_C2 PF13561.6 CAV26184.1 - 3.1e-55 187.3 0.1 3.8e-55 187.0 0.1 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CAV26184.1 - 7.3e-52 175.7 0.2 9.4e-52 175.3 0.2 1.0 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CAV26184.1 - 2.6e-17 63.3 0.1 3.7e-17 62.8 0.1 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 CAV26184.1 - 6.3e-07 29.1 0.0 1.9e-06 27.6 0.0 1.7 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 CAV26184.1 - 0.0011 18.9 0.0 0.0024 17.8 0.0 1.4 1 1 0 1 1 1 1 NAD(P)H-binding GDP_Man_Dehyd PF16363.5 CAV26184.1 - 0.0018 17.8 0.0 0.0025 17.2 0.0 1.3 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase FmdA_AmdA PF03069.15 CAV26184.1 - 0.0075 15.2 0.0 0.01 14.7 0.0 1.2 1 0 0 1 1 1 1 Acetamidase/Formamidase family Thiolase_N PF00108.23 CAV26186.1 - 4.5e-94 314.6 5.8 7.1e-94 314.0 5.8 1.3 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 CAV26186.1 - 2e-44 150.2 3.0 6.2e-44 148.6 0.2 2.6 2 1 0 2 2 2 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.26 CAV26186.1 - 0.0065 16.1 2.0 0.022 14.3 1.5 2.2 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain Dodecin PF07311.12 CAV26186.1 - 0.2 11.9 3.1 0.92 9.8 0.0 3.2 4 0 0 4 4 4 0 Dodecin Phasin_2 PF09361.10 CAV26188.1 - 2.7e-17 62.8 11.6 3.2e-17 62.6 11.6 1.1 1 0 0 1 1 1 1 Phasin protein FapA PF03961.13 CAV26188.1 - 0.014 14.0 3.5 0.017 13.8 3.5 1.0 1 0 0 1 1 1 0 Flagellar Assembly Protein A ThrE PF06738.12 CAV26188.1 - 0.051 12.9 0.7 0.062 12.7 0.7 1.1 1 0 0 1 1 1 0 Putative threonine/serine exporter Ubiq_cyt_C_chap PF03981.12 CAV26188.1 - 0.059 13.4 1.5 0.18 11.9 1.5 1.7 1 1 0 1 1 1 0 Ubiquinol-cytochrome C chaperone THOC7 PF05615.13 CAV26188.1 - 0.36 11.1 5.3 0.46 10.8 5.3 1.1 1 0 0 1 1 1 0 Tho complex subunit 7 Aida_N PF08910.10 CAV26188.1 - 0.36 11.2 4.1 0.27 11.6 0.7 2.0 1 1 1 2 2 2 0 Aida N-terminus PhaC_N PF07167.13 CAV26190.1 - 1.1e-71 240.0 0.3 2.2e-71 239.0 0.3 1.5 1 0 0 1 1 1 1 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus Abhydrolase_1 PF00561.20 CAV26190.1 - 2e-15 57.2 0.0 6.1e-15 55.6 0.0 1.9 1 1 0 1 1 1 1 alpha/beta hydrolase fold DUF3141 PF11339.8 CAV26190.1 - 0.0016 17.0 0.2 0.003 16.0 0.2 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3141) PE-PPE PF08237.11 CAV26190.1 - 0.018 14.6 0.0 0.037 13.6 0.0 1.4 1 0 0 1 1 1 0 PE-PPE domain DUF676 PF05057.14 CAV26190.1 - 0.039 13.5 0.0 0.093 12.2 0.0 1.6 1 0 0 1 1 1 0 Putative serine esterase (DUF676) DUF2860 PF11059.8 CAV26192.1 - 1.4e-109 365.9 2.1 1.6e-109 365.7 2.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2860) HisKA PF00512.25 CAV26194.1 - 1.1e-12 47.7 0.8 2.6e-12 46.6 0.8 1.7 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain Response_reg PF00072.24 CAV26195.1 - 1.8e-26 92.5 0.1 3.5e-26 91.6 0.1 1.5 1 0 0 1 1 1 1 Response regulator receiver domain Trans_reg_C PF00486.28 CAV26195.1 - 6.6e-17 61.4 0.1 1e-16 60.7 0.1 1.3 1 0 0 1 1 1 1 Transcriptional regulatory protein, C terminal ACR_tran PF00873.19 CAV26197.1 - 2.9e-152 508.6 26.5 3.4e-152 508.4 26.5 1.0 1 0 0 1 1 1 1 AcrB/AcrD/AcrF family SecD_SecF PF02355.16 CAV26197.1 - 1.1e-07 31.4 18.0 0.00016 21.2 5.4 2.8 2 0 0 2 2 2 2 Protein export membrane protein MMPL PF03176.15 CAV26197.1 - 3.4e-07 29.5 4.7 3.4e-07 29.5 4.7 2.4 2 0 0 2 2 2 1 MMPL family Flp_Fap PF04964.14 CAV26197.1 - 0.0024 17.7 1.9 3.1 7.7 0.1 3.5 3 0 0 3 3 3 2 Flp/Fap pilin component BofC_C PF08955.10 CAV26197.1 - 0.033 14.3 0.0 0.13 12.4 0.0 2.0 1 0 0 1 1 1 0 BofC C-terminal domain HMA PF00403.26 CAV26197.1 - 0.056 13.9 4.1 1.7 9.2 0.2 3.2 3 0 0 3 3 3 0 Heavy-metal-associated domain DUF2120 PF09893.9 CAV26197.1 - 0.86 9.7 2.6 2.1 8.4 0.3 2.7 3 0 0 3 3 3 0 Uncharacterized protein conserved in archaea (DUF2120) HlyD_3 PF13437.6 CAV26198.1 - 1.6e-14 54.5 0.1 1.1e-09 39.0 0.0 2.5 2 0 0 2 2 2 2 HlyD family secretion protein HlyD_D23 PF16576.5 CAV26198.1 - 3.3e-11 42.8 5.5 5.2e-10 38.9 5.4 2.1 1 1 0 1 1 1 1 Barrel-sandwich domain of CusB or HlyD membrane-fusion Biotin_lipoyl_2 PF13533.6 CAV26198.1 - 7.5e-09 35.3 6.0 0.002 17.9 0.1 4.3 4 2 1 5 5 5 2 Biotin-lipoyl like DUF2564 PF10819.8 CAV26198.1 - 0.083 13.3 0.9 0.083 13.3 0.9 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2564) Mem_trans PF03547.18 CAV26198.1 - 0.086 11.2 0.8 0.13 10.6 0.8 1.3 1 0 0 1 1 1 0 Membrane transport protein DUF4140 PF13600.6 CAV26198.1 - 0.8 10.2 13.1 38 4.8 0.4 3.4 2 1 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) OEP PF02321.18 CAV26200.1 - 8e-26 91.0 35.5 7.8e-17 61.7 8.6 2.1 2 0 0 2 2 2 2 Outer membrane efflux protein DUF3209 PF11483.8 CAV26200.1 - 0.028 14.9 0.1 0.12 12.9 0.1 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3209) DUF3391 PF11871.8 CAV26202.1 - 3.1e-17 63.4 0.2 5.5e-17 62.6 0.2 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3391) HD PF01966.22 CAV26202.1 - 6.8e-14 52.1 0.2 1.2e-13 51.3 0.2 1.4 1 0 0 1 1 1 1 HD domain HD_5 PF13487.6 CAV26202.1 - 9.6e-14 51.4 0.1 1.7e-13 50.6 0.1 1.4 1 0 0 1 1 1 1 HD domain HDOD PF08668.12 CAV26202.1 - 0.048 13.1 0.0 0.086 12.3 0.0 1.4 1 0 0 1 1 1 0 HDOD domain FANCI_S2 PF14676.6 CAV26202.1 - 0.11 12.8 0.2 0.21 11.9 0.2 1.3 1 0 0 1 1 1 0 FANCI solenoid 2 DUF2374 PF09574.10 CAV26204.1 - 6.6e-27 93.1 2.0 7.2e-27 92.9 2.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (Duf2374) VEGFR-2_TMD PF17988.1 CAV26204.1 - 0.072 12.5 1.1 0.1 12.0 1.1 1.3 1 0 0 1 1 1 0 VEGFR-2 Transmembrane domain Cytochrom_NNT PF03264.14 CAV26205.1 - 2.1e-69 232.7 4.4 2.4e-69 232.5 4.4 1.0 1 0 0 1 1 1 1 NapC/NirT cytochrome c family, N-terminal region Paired_CXXCH_1 PF09699.10 CAV26205.1 - 9.8e-08 31.6 9.5 0.0087 15.8 3.9 3.3 3 0 0 3 3 3 3 Doubled CXXCH motif (Paired_CXXCH_1) Cytochrome_C7 PF14522.6 CAV26205.1 - 0.0002 21.3 17.8 0.5 10.4 1.2 3.3 1 1 1 2 2 2 2 Cytochrome c7 and related cytochrome c Cytochrom_c3_2 PF14537.6 CAV26205.1 - 0.00028 21.3 15.8 0.93 10.0 2.2 2.6 1 1 1 2 2 2 2 Cytochrome c3 DUF2321 PF10083.9 CAV26205.1 - 0.012 15.3 0.1 0.012 15.3 0.1 1.8 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2321) EamA PF00892.20 CAV26205.1 - 0.11 12.7 0.2 0.14 12.4 0.2 1.1 1 0 0 1 1 1 0 EamA-like transporter family zf-C2HE PF16278.5 CAV26205.1 - 0.21 12.1 3.2 1.9 9.0 0.8 2.4 1 1 1 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger Cytochrom_CIII PF02085.16 CAV26205.1 - 0.23 11.8 16.8 0.83 10.0 6.3 2.9 1 1 2 3 3 3 0 Class III cytochrome C family DZR PF12773.7 CAV26205.1 - 0.51 10.4 9.5 0.43 10.6 0.3 2.9 2 1 0 2 2 2 0 Double zinc ribbon PSCyt3 PF07627.11 CAV26205.1 - 0.97 9.7 15.9 4.6 7.6 3.7 3.7 1 1 3 4 4 4 0 Protein of unknown function (DUF1588) Cytochrome_C554 PF13435.6 CAV26205.1 - 1.8 9.5 17.6 2.3 9.2 1.7 3.4 1 1 1 2 2 2 0 Cytochrome c554 and c-prime Cytochrome_P460 PF16694.5 CAV26205.1 - 1.9 8.9 17.8 7.6 6.9 0.6 4.0 2 2 2 4 4 4 0 Cytochrome P460 GSu_C4xC__C2xCH PF09698.10 CAV26205.1 - 4.3 8.2 9.2 91 4.0 0.0 4.2 4 0 0 4 4 4 0 Geobacter CxxxxCH...CXXCH motif (GSu_C4xC__C2xCH) NapB PF03892.14 CAV26207.1 - 8.8e-50 168.0 0.0 1e-49 167.8 0.0 1.0 1 0 0 1 1 1 1 Nitrate reductase cytochrome c-type subunit (NapB) Cytochrome_C7 PF14522.6 CAV26207.1 - 0.0022 18.0 0.4 0.0036 17.3 0.4 1.3 1 0 0 1 1 1 1 Cytochrome c7 and related cytochrome c Cytochrom_NNT PF03264.14 CAV26207.1 - 0.0063 16.2 0.7 0.011 15.5 0.7 1.3 1 0 0 1 1 1 1 NapC/NirT cytochrome c family, N-terminal region Cytochrome_C554 PF13435.6 CAV26207.1 - 0.012 16.5 1.4 0.43 11.5 1.6 2.2 1 1 1 2 2 2 0 Cytochrome c554 and c-prime Paired_CXXCH_1 PF09699.10 CAV26207.1 - 0.015 15.0 3.3 0.17 11.7 3.4 2.1 1 1 1 2 2 2 0 Doubled CXXCH motif (Paired_CXXCH_1) Cytochrome_CBB3 PF13442.6 CAV26207.1 - 0.023 15.0 0.7 8.9 6.7 0.0 2.3 1 1 0 2 2 2 0 Cytochrome C oxidase, cbb3-type, subunit III zf-CHY PF05495.12 CAV26207.1 - 0.025 15.1 1.1 0.59 10.7 0.0 2.1 1 1 1 2 2 2 0 CHY zinc finger DUF3365 PF11845.8 CAV26207.1 - 0.041 14.2 2.0 2.7 8.3 0.2 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF3365) Cytochrom_CIII PF02085.16 CAV26207.1 - 0.059 13.7 0.3 0.1 13.0 0.3 1.3 1 0 0 1 1 1 0 Class III cytochrome C family Cytochrom_c3_2 PF14537.6 CAV26207.1 - 0.065 13.7 1.4 0.21 12.1 1.3 1.6 1 1 0 1 1 1 0 Cytochrome c3 Cytochrome_P460 PF16694.5 CAV26207.1 - 0.11 12.9 0.4 15 6.0 0.1 2.3 2 0 0 2 2 2 0 Cytochrome P460 Molybdopterin PF00384.22 CAV26209.1 - 3.2e-90 303.2 0.8 4.1e-90 302.8 0.8 1.1 1 0 0 1 1 1 1 Molybdopterin oxidoreductase Molydop_binding PF01568.21 CAV26209.1 - 1.3e-27 96.0 0.0 3.1e-27 94.8 0.0 1.7 1 0 0 1 1 1 1 Molydopterin dinucleotide binding domain Molybdop_Fe4S4 PF04879.16 CAV26209.1 - 8.8e-17 60.8 0.4 2.1e-16 59.7 0.4 1.7 1 0 0 1 1 1 1 Molybdopterin oxidoreductase Fe4S4 domain TAT_signal PF10518.9 CAV26209.1 - 0.15 11.9 6.1 0.31 10.9 6.1 1.6 1 0 0 1 1 1 0 TAT (twin-arginine translocation) pathway signal sequence NapD PF03927.13 CAV26211.1 - 6.8e-28 96.5 2.6 8.1e-28 96.3 2.6 1.1 1 0 0 1 1 1 1 NapD protein Fer4 PF00037.27 CAV26213.1 - 1.9e-16 59.1 31.1 1.1e-07 31.4 3.5 4.4 4 0 0 4 4 4 3 4Fe-4S binding domain Fer4_7 PF12838.7 CAV26213.1 - 3.5e-15 56.3 24.7 1.1e-07 32.3 6.6 2.5 2 1 0 2 2 2 2 4Fe-4S dicluster domain Fer4_9 PF13187.6 CAV26213.1 - 4.3e-15 55.6 23.2 2.6e-07 30.7 9.5 2.4 2 1 0 2 2 2 2 4Fe-4S dicluster domain Fer4_21 PF14697.6 CAV26213.1 - 3e-12 46.5 24.6 1.3e-06 28.5 8.2 2.3 2 0 0 2 2 2 2 4Fe-4S dicluster domain Fer4_16 PF13484.6 CAV26213.1 - 3.5e-10 40.7 28.2 0.0016 19.3 3.0 4.1 3 1 1 4 4 4 3 4Fe-4S double cluster binding domain Fer4_10 PF13237.6 CAV26213.1 - 2e-08 34.2 34.1 0.00036 20.6 2.7 3.4 1 1 3 4 4 4 4 4Fe-4S dicluster domain Fer4_4 PF12800.7 CAV26213.1 - 3.1e-08 33.5 33.0 0.00069 19.9 3.3 4.2 4 0 0 4 4 4 3 4Fe-4S binding domain Fer4_6 PF12837.7 CAV26213.1 - 6.5e-08 32.3 32.8 2.4e-05 24.2 2.8 4.3 4 0 0 4 4 4 3 4Fe-4S binding domain Fer4_17 PF13534.6 CAV26213.1 - 1.2e-07 32.2 25.6 0.0085 16.6 0.2 3.6 2 1 0 2 2 2 2 4Fe-4S dicluster domain Fer4_8 PF13183.6 CAV26213.1 - 2.3e-07 31.1 28.6 0.008 16.6 0.1 4.1 2 1 1 3 3 3 3 4Fe-4S dicluster domain Fer4_2 PF12797.7 CAV26213.1 - 9.6e-07 28.5 33.8 5.2e-05 23.1 2.8 4.4 4 0 0 4 4 4 3 4Fe-4S binding domain Fer4_15 PF13459.6 CAV26213.1 - 0.00048 20.8 22.3 0.037 14.8 1.2 3.5 2 1 1 3 3 3 2 4Fe-4S single cluster domain Fer4_3 PF12798.7 CAV26213.1 - 0.0046 17.8 42.5 0.019 15.9 7.3 4.2 4 0 0 4 4 4 3 4Fe-4S binding domain Fer4_18 PF13746.6 CAV26213.1 - 0.0088 16.2 30.5 0.45 10.7 3.2 3.9 1 1 2 3 3 3 2 4Fe-4S dicluster domain Fer4_13 PF13370.6 CAV26213.1 - 0.034 14.7 29.9 0.041 14.4 3.1 4.1 4 0 0 4 4 4 0 4Fe-4S single cluster domain of Ferredoxin I Fer4_22 PF17179.4 CAV26213.1 - 0.21 12.4 25.5 0.85 10.5 0.3 3.8 2 1 1 3 3 3 0 4Fe-4S dicluster domain PilJ PF13675.6 CAV26214.1 - 8.2e-23 80.6 0.4 2.4e-21 75.9 0.0 2.6 2 0 0 2 2 2 1 Type IV pili methyl-accepting chemotaxis transducer N-term HisKA_3 PF07730.13 CAV26214.1 - 1.2e-17 64.1 0.6 5.9e-17 61.9 0.6 2.2 1 0 0 1 1 1 1 Histidine kinase HAMP PF00672.25 CAV26214.1 - 7.2e-11 42.3 0.0 2.2e-10 40.7 0.0 1.9 1 0 0 1 1 1 1 HAMP domain HATPase_c PF02518.26 CAV26214.1 - 2.9e-09 37.4 0.2 1.7e-08 35.0 0.2 2.4 1 1 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_2 PF13581.6 CAV26214.1 - 2.6e-06 27.4 0.0 7e-06 26.0 0.0 1.7 1 0 0 1 1 1 1 Histidine kinase-like ATPase domain HATPase_c_3 PF13589.6 CAV26214.1 - 0.075 12.9 0.6 1.5 8.7 0.1 2.5 2 0 0 2 2 2 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 CAV26216.1 - 1.4e-31 109.0 0.2 2.5e-31 108.1 0.2 1.4 1 0 0 1 1 1 1 Response regulator receiver domain GerE PF00196.19 CAV26216.1 - 1.2e-22 79.2 0.2 1.9e-22 78.5 0.2 1.4 1 0 0 1 1 1 1 Bacterial regulatory proteins, luxR family Sigma70_r4 PF04545.16 CAV26216.1 - 1.5e-06 27.6 0.1 2.8e-06 26.7 0.1 1.5 1 0 0 1 1 1 1 Sigma-70, region 4 Sigma70_r4_2 PF08281.12 CAV26216.1 - 2.4e-05 23.9 0.1 4.7e-05 23.0 0.1 1.5 1 0 0 1 1 1 1 Sigma-70, region 4 HTH_23 PF13384.6 CAV26216.1 - 3.3e-05 23.5 0.0 8.7e-05 22.2 0.0 1.7 1 1 0 1 1 1 1 Homeodomain-like domain HTH_24 PF13412.6 CAV26216.1 - 8.1e-05 22.1 0.0 0.00018 21.0 0.0 1.6 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding Phage_terminase PF10668.9 CAV26216.1 - 0.0031 17.5 0.1 0.02 14.9 0.0 2.1 2 0 0 2 2 2 1 Phage terminase small subunit HTH_5 PF01022.20 CAV26216.1 - 0.01 15.6 0.1 0.026 14.4 0.1 1.8 1 1 0 1 1 1 0 Bacterial regulatory protein, arsR family HTH_28 PF13518.6 CAV26216.1 - 0.012 15.7 0.1 0.044 13.9 0.0 2.0 2 0 0 2 2 2 0 Helix-turn-helix domain HTH_10 PF04967.12 CAV26216.1 - 0.034 14.0 1.0 0.86 9.5 0.8 2.8 2 1 0 2 2 2 0 HTH DNA binding domain Terminase_5 PF06056.12 CAV26216.1 - 0.05 13.5 0.1 0.36 10.8 0.0 2.1 2 0 0 2 2 2 0 Putative ATPase subunit of terminase (gpP-like) HTH_11 PF08279.12 CAV26216.1 - 0.085 12.8 0.3 0.34 10.9 0.1 2.2 2 0 0 2 2 2 0 HTH domain Mga PF05043.13 CAV26216.1 - 0.12 13.0 0.1 0.2 12.3 0.1 1.4 1 0 0 1 1 1 0 Mga helix-turn-helix domain DcuC PF03606.15 CAV26218.1 - 1.1e-124 416.5 38.2 1.2e-124 416.3 38.2 1.0 1 0 0 1 1 1 1 C4-dicarboxylate anaerobic carrier DctM PF06808.12 CAV26218.1 - 2.4e-06 26.7 33.7 2.4e-06 26.7 33.7 2.0 1 1 1 2 2 2 1 Tripartite ATP-independent periplasmic transporter, DctM component Na_H_antiporter PF03553.14 CAV26218.1 - 3.9 6.6 44.3 0.13 11.5 16.6 2.2 1 1 1 2 2 2 0 Na+/H+ antiporter family CitMHS PF03600.16 CAV26218.1 - 5.2 6.2 54.4 0.022 14.0 21.5 2.2 1 1 1 2 2 2 0 Citrate transporter UTRA PF07702.13 CAV26220.1 - 2.1e-33 115.2 0.0 3.1e-33 114.6 0.0 1.3 1 0 0 1 1 1 1 UTRA domain GntR PF00392.21 CAV26220.1 - 3.2e-20 71.5 0.2 5.9e-20 70.7 0.2 1.4 1 0 0 1 1 1 1 Bacterial regulatory proteins, gntR family HTH_11 PF08279.12 CAV26220.1 - 0.0016 18.3 0.2 0.0046 16.9 0.0 1.8 2 0 0 2 2 2 1 HTH domain TPR_22 PF18833.1 CAV26220.1 - 0.097 12.8 0.7 0.24 11.6 0.7 1.7 1 1 0 1 1 1 0 Tetratricopeptide repeat HTH_41 PF14502.6 CAV26220.1 - 0.13 11.9 0.0 0.24 11.1 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain PTS_EIIA_2 PF00359.22 CAV26221.1 - 7.6e-39 132.9 0.1 1.2e-38 132.2 0.1 1.3 1 0 0 1 1 1 1 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 PTS_IIB PF02302.17 CAV26221.1 - 2.1e-16 60.4 0.1 4.5e-16 59.3 0.1 1.6 1 0 0 1 1 1 1 PTS system, Lactose/Cellobiose specific IIB subunit Glyco_hydro_38N PF01074.22 CAV26223.1 - 6.4e-36 124.2 0.0 1.1e-35 123.4 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 N-terminal domain Glyco_hydro_38C PF07748.13 CAV26223.1 - 2.3e-26 93.2 0.6 4.3e-26 92.3 0.0 1.7 2 0 0 2 2 2 1 Glycosyl hydrolases family 38 C-terminal domain Alpha-mann_mid PF09261.11 CAV26223.1 - 1.9e-08 34.4 0.1 4.4e-08 33.2 0.1 1.7 1 0 0 1 1 1 1 Alpha mannosidase middle domain Glyco_hydro38C2 PF17677.1 CAV26223.1 - 2.5e-05 24.3 0.0 8.5e-05 22.6 0.0 2.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 C-terminal beta sandwich domain DUF2330 PF10092.9 CAV26223.1 - 0.041 13.0 0.0 0.072 12.2 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2330) Gly_kinase PF02595.15 CAV26225.1 - 6.2e-134 446.6 9.7 7e-134 446.4 9.7 1.0 1 0 0 1 1 1 1 Glycerate kinase family PMI_typeI PF01238.21 CAV26227.1 - 2.9e-87 293.3 0.0 2.2e-86 290.4 0.0 2.1 2 1 0 2 2 2 1 Phosphomannose isomerase type I Cupin_2 PF07883.11 CAV26227.1 - 4.5e-07 29.5 0.0 0.00012 21.7 0.0 2.3 2 0 0 2 2 2 2 Cupin domain AraC_binding PF02311.19 CAV26227.1 - 0.0044 16.9 0.0 0.67 9.9 0.0 2.4 2 0 0 2 2 2 1 AraC-like ligand binding domain EutQ PF06249.12 CAV26227.1 - 0.0085 15.9 0.0 0.015 15.1 0.0 1.3 1 0 0 1 1 1 1 Ethanolamine utilisation protein EutQ Cupin_3 PF05899.12 CAV26227.1 - 0.01 15.5 0.0 0.02 14.6 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF861) Cupin_6 PF12852.7 CAV26227.1 - 0.054 13.2 0.0 2.3 7.9 0.0 2.2 2 0 0 2 2 2 0 Cupin Ectoine_synth PF06339.12 CAV26227.1 - 0.073 13.3 0.0 0.13 12.4 0.0 1.4 1 0 0 1 1 1 0 Ectoine synthase AraC_binding_2 PF14525.6 CAV26227.1 - 0.13 11.9 0.0 0.26 10.9 0.0 1.4 1 0 0 1 1 1 0 AraC-binding-like domain Lyx_isomer PF07385.12 CAV26227.1 - 0.14 11.4 0.0 0.71 9.1 0.0 1.9 2 0 0 2 2 2 0 D-lyxose isomerase ABM PF03992.16 CAV26229.1 - 1.2e-15 57.3 0.1 1.8e-15 56.8 0.1 1.3 1 0 0 1 1 1 1 Antibiotic biosynthesis monooxygenase LPD28 PF18843.1 CAV26229.1 - 0.042 13.5 0.0 0.063 12.9 0.0 1.4 1 0 0 1 1 1 0 Large polyvalent protein associated domain 28 FA_desaturase PF00487.24 CAV26230.1 - 3.8e-22 79.3 19.0 3.8e-22 79.3 19.0 2.0 1 1 1 2 2 2 2 Fatty acid desaturase Acetyltransf_1 PF00583.25 CAV26232.1 - 5.3e-15 55.7 0.0 7.3e-15 55.2 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 CAV26232.1 - 4e-10 39.7 0.0 6.1e-10 39.1 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 CAV26232.1 - 5.7e-10 39.5 0.2 9.1e-10 38.8 0.2 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 CAV26232.1 - 3.2e-08 33.4 0.0 5e-08 32.8 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_4 PF13420.7 CAV26232.1 - 0.0076 16.4 0.0 0.0097 16.0 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.6 CAV26232.1 - 0.034 13.8 0.0 0.051 13.3 0.0 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.7 CAV26232.1 - 0.072 13.8 0.0 0.094 13.4 0.0 1.1 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_15 PF17013.5 CAV26232.1 - 0.11 12.0 0.0 0.15 11.5 0.0 1.3 1 0 0 1 1 1 0 Putative acetyl-transferase Acetyltransf_CG PF14542.6 CAV26232.1 - 0.11 12.6 0.0 0.32 11.2 0.0 1.7 1 1 0 1 1 1 0 GCN5-related N-acetyl-transferase MMR_HSR1 PF01926.23 CAV26234.1 - 3.6e-15 56.0 0.0 2.8e-13 50.0 0.0 2.5 2 0 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 CAV26234.1 - 2.5e-10 40.1 0.9 2.7e-06 27.0 0.1 2.5 2 0 0 2 2 2 2 Ferrous iron transport protein B RsgA_GTPase PF03193.16 CAV26234.1 - 1e-07 32.0 0.2 3.1e-07 30.5 0.2 1.8 1 1 0 1 1 1 1 RsgA GTPase Dynamin_N PF00350.23 CAV26234.1 - 0.0009 19.3 2.4 0.011 15.8 0.0 3.2 3 2 1 4 4 4 1 Dynamin family MeaB PF03308.16 CAV26234.1 - 0.0054 15.8 0.4 0.019 14.0 0.2 1.9 1 1 1 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB PduV-EutP PF10662.9 CAV26234.1 - 0.0075 16.0 0.1 4.7 7.0 0.0 2.4 2 0 0 2 2 2 2 Ethanolamine utilisation - propanediol utilisation Arf PF00025.21 CAV26234.1 - 0.014 14.9 0.2 0.06 12.8 0.1 2.1 1 1 1 2 2 2 0 ADP-ribosylation factor family Ribonuc_2-5A PF06479.12 CAV26234.1 - 0.088 13.0 0.1 12 6.1 0.0 2.3 2 0 0 2 2 2 0 Ribonuclease 2-5A GTP_EFTU PF00009.27 CAV26234.1 - 0.1 12.1 0.0 4.7 6.7 0.0 2.3 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain ABC_tran PF00005.27 CAV26234.1 - 0.1 13.1 0.0 0.26 11.8 0.0 1.8 2 0 0 2 2 2 0 ABC transporter PAAR_motif PF05488.13 CAV26236.1 - 1.1e-20 73.6 8.3 6.3e-20 71.1 2.5 2.8 1 1 2 3 3 3 2 PAAR motif DUF4150 PF13665.6 CAV26236.1 - 0.0015 18.7 1.1 0.0062 16.7 0.0 2.1 1 1 1 2 2 2 1 Domain of unknown function (DUF4150) Aldedh PF00171.22 CAV26244.1 - 1.1e-170 568.2 0.0 1.2e-170 568.0 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DUF1487 PF07368.11 CAV26244.1 - 0.051 13.0 0.0 1.2 8.6 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1487) HTH_18 PF12833.7 CAV26248.1 - 5e-23 81.2 0.3 8.6e-23 80.4 0.3 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 CAV26248.1 - 3.5e-19 68.4 0.1 3e-11 43.1 0.1 2.5 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family DJ-1_PfpI PF01965.24 CAV26248.1 - 2e-08 34.2 0.0 4.3e-08 33.1 0.0 1.6 2 0 0 2 2 2 1 DJ-1/PfpI family DnaB_2 PF07261.11 CAV26248.1 - 0.19 11.5 0.5 2.6 7.8 0.1 2.9 3 1 0 3 3 3 0 Replication initiation and membrane attachment Trans_reg_C PF00486.28 CAV26252.1 - 1.9e-15 56.7 0.0 3.2e-15 55.9 0.0 1.4 1 0 0 1 1 1 1 Transcriptional regulatory protein, C terminal Trans_reg_C PF00486.28 CAV26254.1 - 1.7e-14 53.6 0.1 2.8e-14 52.9 0.1 1.4 1 0 0 1 1 1 1 Transcriptional regulatory protein, C terminal DUF2140 PF09911.9 CAV26254.1 - 0.016 14.7 0.3 0.036 13.6 0.2 1.7 1 1 1 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2140) Redoxin PF08534.10 CAV26257.1 - 1.2e-15 57.5 0.0 1.5e-15 57.2 0.0 1.1 1 0 0 1 1 1 1 Redoxin AhpC-TSA PF00578.21 CAV26257.1 - 4.9e-08 32.9 0.1 6.5e-08 32.5 0.1 1.2 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 CAV26259.1 - 1.8e-30 105.6 0.1 2.2e-30 105.3 0.1 1.0 1 0 0 1 1 1 1 Redoxin AhpC-TSA PF00578.21 CAV26259.1 - 1.4e-17 63.7 0.0 1.7e-17 63.5 0.0 1.1 1 0 0 1 1 1 1 AhpC/TSA family DUF1275 PF06912.11 CAV26262.1 - 0.055 13.4 0.0 0.061 13.2 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1275) Yae1_N PF09811.9 CAV26262.1 - 0.058 13.1 0.0 0.088 12.5 0.0 1.2 1 0 0 1 1 1 0 Essential protein Yae1, N terminal SgrR_N PF12793.7 CAV26264.1 - 2.2e-19 69.8 0.3 5.4e-19 68.5 0.3 1.6 1 0 0 1 1 1 1 Sugar transport-related sRNA regulator N-term SBP_bac_5 PF00496.22 CAV26264.1 - 3.1e-12 46.1 0.0 4.2e-12 45.7 0.0 1.2 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 5 Middle HTH_11 PF08279.12 CAV26264.1 - 0.062 13.3 0.1 0.15 12.0 0.1 1.7 1 0 0 1 1 1 0 HTH domain SPO11_like PF03533.14 CAV26264.1 - 0.076 13.1 0.0 3.3 7.9 0.1 2.5 2 0 0 2 2 2 0 SPO11 homologue HTH_Crp_2 PF13545.6 CAV26264.1 - 0.1 12.6 0.5 0.29 11.2 0.1 1.9 2 0 0 2 2 2 0 Crp-like helix-turn-helix domain Rrf2 PF02082.20 CAV26264.1 - 0.16 12.3 0.1 0.44 10.9 0.0 1.7 2 0 0 2 2 2 0 Transcriptional regulator Asp_Glu_race PF01177.22 CAV26266.1 - 3e-21 76.3 0.0 3.4e-21 76.1 0.0 1.0 1 0 0 1 1 1 1 Asp/Glu/Hydantoin racemase GerE PF00196.19 CAV26268.1 - 7.7e-20 70.2 0.7 1.2e-19 69.6 0.7 1.3 1 0 0 1 1 1 1 Bacterial regulatory proteins, luxR family Sigma70_r4_2 PF08281.12 CAV26268.1 - 0.00068 19.3 0.0 0.0012 18.4 0.0 1.4 1 0 0 1 1 1 1 Sigma-70, region 4 Botulinum_HA-17 PF05588.11 CAV26268.1 - 0.011 15.9 1.5 0.054 13.6 0.1 2.2 2 0 0 2 2 2 0 Clostridium botulinum HA-17 domain Sigma70_r4 PF04545.16 CAV26268.1 - 0.012 15.1 0.0 0.026 14.0 0.0 1.5 1 0 0 1 1 1 0 Sigma-70, region 4 HTH_23 PF13384.6 CAV26268.1 - 0.03 14.1 0.0 0.12 12.2 0.0 2.0 2 0 0 2 2 2 0 Homeodomain-like domain SCPU PF05229.15 CAV26270.1 - 0.0033 17.8 0.0 0.11 12.8 0.0 2.4 2 0 0 2 2 2 2 Spore Coat Protein U domain Usher PF00577.20 CAV26272.1 - 7.2e-20 71.3 10.4 1.1e-19 70.8 10.4 1.2 1 0 0 1 1 1 1 Outer membrane usher protein CarboxypepD_reg PF13620.6 CAV26272.1 - 0.0018 18.5 0.0 0.0081 16.4 0.0 2.2 2 0 0 2 2 2 1 Carboxypeptidase regulatory-like domain CarbopepD_reg_2 PF13715.6 CAV26272.1 - 0.017 15.1 0.0 0.1 12.6 0.0 2.2 2 0 0 2 2 2 0 CarboxypepD_reg-like domain Cadherin-like PF12733.7 CAV26272.1 - 0.02 15.4 0.1 0.55 10.8 0.0 2.9 2 0 0 2 2 2 0 Cadherin-like beta sandwich domain PapD_N PF00345.20 CAV26274.1 - 0.00012 22.0 0.0 0.0002 21.2 0.0 1.4 1 0 0 1 1 1 1 Pili and flagellar-assembly chaperone, PapD N-terminal domain PapD_C PF02753.17 CAV26274.1 - 0.00069 19.9 0.2 5.2 7.5 0.0 3.4 2 1 1 3 3 3 3 Pili assembly chaperone PapD, C-terminal domain ACT_5 PF13710.6 CAV26276.1 - 0.033 14.0 0.1 0.54 10.1 0.0 2.5 2 0 0 2 2 2 0 ACT domain SCPU PF05229.15 CAV26278.1 - 0.01 16.3 2.0 2 8.8 0.2 2.2 2 0 0 2 2 2 0 Spore Coat Protein U domain Beta_elim_lyase PF01212.21 CAV26281.1 - 1.9e-96 322.8 0.4 2.3e-96 322.5 0.4 1.0 1 0 0 1 1 1 1 Beta-eliminating lyase Aminotran_1_2 PF00155.21 CAV26281.1 - 8.5e-07 28.5 0.0 1.1e-06 28.1 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II DegT_DnrJ_EryC1 PF01041.17 CAV26281.1 - 0.00036 19.9 0.0 0.0017 17.8 0.0 1.9 2 0 0 2 2 2 1 DegT/DnrJ/EryC1/StrS aminotransferase family Cys_Met_Meta_PP PF01053.20 CAV26281.1 - 0.0024 16.5 0.0 0.0039 15.8 0.0 1.3 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme NUDIX PF00293.28 CAV26283.1 - 6.2e-18 65.1 0.0 2.3e-17 63.3 0.0 1.7 2 0 0 2 2 2 1 NUDIX domain DUF3763 PF12592.8 CAV26283.1 - 0.24 11.5 1.6 17 5.5 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3763) AAA_lid_8 PF17868.1 CAV26285.1 - 6.9e-24 83.5 0.0 1.5e-23 82.4 0.0 1.5 1 0 0 1 1 1 1 AAA lid domain AAA_5 PF07728.14 CAV26285.1 - 7.1e-23 81.1 0.0 1.5e-22 80.1 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) DUF3763 PF12592.8 CAV26285.1 - 9.5e-19 67.2 1.4 1.6e-18 66.4 0.1 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF3763) AAA_3 PF07726.11 CAV26285.1 - 4.7e-05 23.3 0.0 8.8e-05 22.4 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA PF00004.29 CAV26285.1 - 0.00017 22.0 0.0 0.00047 20.6 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Mg_chelatase PF01078.21 CAV26285.1 - 0.00021 20.7 0.0 0.0046 16.4 0.0 2.8 3 0 0 3 3 3 1 Magnesium chelatase, subunit ChlI AAA_2 PF07724.14 CAV26285.1 - 0.0022 18.1 0.0 0.0072 16.5 0.0 1.8 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) Sigma54_activat PF00158.26 CAV26285.1 - 0.0068 16.1 0.0 0.5 10.1 0.0 2.3 2 0 0 2 2 2 1 Sigma-54 interaction domain AAA_16 PF13191.6 CAV26285.1 - 0.0095 16.3 0.0 0.054 13.9 0.0 2.3 2 0 0 2 2 2 1 AAA ATPase domain Guanylate_kin PF00625.21 CAV26285.1 - 0.024 14.3 0.7 2.5 7.7 0.0 3.2 3 1 0 3 3 3 0 Guanylate kinase AAA_7 PF12775.7 CAV26285.1 - 0.062 12.8 0.0 0.19 11.2 0.0 1.8 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_22 PF13401.6 CAV26285.1 - 0.1 12.8 0.0 0.62 10.3 0.0 2.3 1 1 0 1 1 1 0 AAA domain AAA_lid_2 PF17863.1 CAV26285.1 - 0.15 11.9 0.0 0.5 10.3 0.0 1.9 1 0 0 1 1 1 0 AAA lid domain VWA_CoxE PF05762.14 CAV26287.1 - 3.8e-09 36.3 0.0 6.1e-09 35.6 0.0 1.3 1 0 0 1 1 1 1 VWA domain containing CoxE-like protein VWA_3 PF13768.6 CAV26287.1 - 0.00057 19.8 0.1 0.0026 17.7 0.0 2.1 2 0 0 2 2 2 1 von Willebrand factor type A domain VWA_2 PF13519.6 CAV26287.1 - 0.00059 20.5 0.0 0.0022 18.6 0.0 2.0 1 0 0 1 1 1 1 von Willebrand factor type A domain DUF2201 PF09967.9 CAV26287.1 - 0.07 13.3 0.0 0.44 10.7 0.0 2.3 1 1 1 2 2 2 0 VWA-like domain (DUF2201) Lipase_3 PF01764.25 CAV26289.1 - 1e-26 93.5 0.0 1.5e-26 93.0 0.0 1.2 1 0 0 1 1 1 1 Lipase (class 3) DUF676 PF05057.14 CAV26289.1 - 0.03 13.8 0.0 0.062 12.8 0.0 1.5 2 0 0 2 2 2 0 Putative serine esterase (DUF676) Hydrolase_4 PF12146.8 CAV26289.1 - 0.034 13.4 0.0 0.14 11.4 0.0 1.8 2 0 0 2 2 2 0 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 CAV26289.1 - 0.043 14.4 0.0 0.049 14.2 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 CAV26289.1 - 0.12 12.0 0.0 0.18 11.5 0.0 1.2 1 0 0 1 1 1 0 alpha/beta hydrolase fold DUF2974 PF11187.8 CAV26289.1 - 0.13 11.8 0.0 0.25 10.8 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) HEAT_2 PF13646.6 CAV26293.1 - 0.00052 20.3 1.8 3.2 8.2 0.0 5.1 5 1 0 5 5 5 1 HEAT repeats HEAT PF02985.22 CAV26293.1 - 0.057 13.7 0.3 6.8 7.2 0.0 4.1 4 0 0 4 4 4 0 HEAT repeat CCP_MauG PF03150.14 CAV26297.1 - 2.6e-33 115.8 0.0 3.9e-30 105.5 0.0 2.3 1 1 1 2 2 2 2 Di-haem cytochrome c peroxidase Cytochrom_C PF00034.21 CAV26297.1 - 4.6e-08 34.1 0.1 0.0029 18.7 0.5 3.0 2 1 0 2 2 2 2 Cytochrome c DHOR PF06537.11 CAV26297.1 - 9.5e-06 24.5 0.1 4.9e-05 22.1 0.0 2.1 2 1 0 2 2 2 1 Di-haem oxidoreductase, putative peroxidase DUF1924 PF09086.11 CAV26297.1 - 0.00079 19.7 0.4 0.71 10.3 0.0 2.5 2 0 0 2 2 2 2 Domain of unknown function (DUF1924) Cytochrome_CBB3 PF13442.6 CAV26297.1 - 0.0042 17.4 0.1 3.7 7.9 0.1 3.3 3 0 0 3 3 3 1 Cytochrome C oxidase, cbb3-type, subunit III Cytochrome_C7 PF14522.6 CAV26297.1 - 0.021 14.8 0.1 3.3 7.8 0.1 2.3 2 0 0 2 2 2 0 Cytochrome c7 and related cytochrome c Paired_CXXCH_1 PF09699.10 CAV26297.1 - 0.027 14.2 1.1 5.1 6.9 0.2 2.4 2 0 0 2 2 2 0 Doubled CXXCH motif (Paired_CXXCH_1) CCP_MauG PF03150.14 CAV26299.1 - 7.9e-39 133.7 0.0 3.5e-35 121.9 0.0 2.3 2 0 0 2 2 2 2 Di-haem cytochrome c peroxidase Cytochrom_C PF00034.21 CAV26299.1 - 2.3e-05 25.4 0.1 0.0042 18.2 0.0 2.7 2 1 0 2 2 2 1 Cytochrome c Cytochrome_CBB3 PF13442.6 CAV26299.1 - 0.0024 18.1 0.1 0.42 11.0 0.0 2.7 2 0 0 2 2 2 1 Cytochrome C oxidase, cbb3-type, subunit III Cytochrome_C7 PF14522.6 CAV26299.1 - 0.059 13.4 0.0 1.3 9.1 0.0 2.2 2 0 0 2 2 2 0 Cytochrome c7 and related cytochrome c Cytochrom_C550 PF14495.6 CAV26299.1 - 0.16 11.7 0.1 1.1 8.9 0.0 2.3 3 0 0 3 3 3 0 Cytochrome c-550 domain Defensin_5 PF18251.1 CAV26299.1 - 1.1 9.5 3.3 1.3 9.2 0.4 2.1 2 0 0 2 2 2 0 Fungal defensin Copsin Rieske PF00355.26 CAV26300.1 - 2.3e-07 30.6 0.0 3.8e-07 30.0 0.0 1.4 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain TAT_signal PF10518.9 CAV26300.1 - 1.6e-05 24.5 0.3 2.8e-05 23.7 0.3 1.4 1 0 0 1 1 1 1 TAT (twin-arginine translocation) pathway signal sequence UCR_Fe-S_N PF10399.9 CAV26300.1 - 0.14 11.5 0.0 0.3 10.5 0.0 1.5 1 0 0 1 1 1 0 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal Rieske_3 PF18465.1 CAV26302.1 - 6.9e-37 125.6 0.1 1.9e-36 124.2 0.1 1.8 1 0 0 1 1 1 1 Rieske 3Fe-4S Molybdopterin PF00384.22 CAV26302.1 - 3.6e-36 125.1 0.1 5.1e-36 124.6 0.1 1.2 1 0 0 1 1 1 1 Molybdopterin oxidoreductase Molydop_binding PF01568.21 CAV26302.1 - 7.5e-14 51.7 0.2 9.9e-08 32.0 0.0 2.8 2 0 0 2 2 2 2 Molydopterin dinucleotide binding domain Molybdop_Fe4S4 PF04879.16 CAV26302.1 - 0.2 11.7 0.4 0.44 10.6 0.4 1.5 1 0 0 1 1 1 0 Molybdopterin oxidoreductase Fe4S4 domain CopD PF05425.13 CAV26304.1 - 4.1e-09 36.8 2.0 4.1e-09 36.8 2.0 1.8 2 0 0 2 2 2 1 Copper resistance protein D Copper-bind PF00127.20 CAV26306.1 - 4.5e-08 33.4 0.2 1.1e-07 32.2 0.2 1.6 1 1 0 1 1 1 1 Copper binding proteins, plastocyanin/azurin family Cupredoxin_1 PF13473.6 CAV26306.1 - 0.0031 17.6 0.0 0.0047 17.0 0.0 1.2 1 0 0 1 1 1 1 Cupredoxin-like domain Sarcoglycan_1 PF04790.13 CAV26306.1 - 0.067 12.5 0.0 0.15 11.4 0.0 1.5 1 1 0 2 2 2 0 Sarcoglycan complex subunit protein DUF2645 PF10840.8 CAV26308.1 - 0.051 14.2 0.0 0.085 13.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2645) DUF4149 PF13664.6 CAV26311.1 - 0.12 12.7 3.9 0.21 11.9 3.9 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4149) DEDD_Tnp_IS110 PF01548.17 CAV26315.1 - 2.7e-07 30.6 0.1 3.3e-07 30.3 0.1 1.2 1 0 0 1 1 1 1 Transposase Fe-ADH PF00465.19 CAV26315.1 - 0.039 12.8 0.0 0.044 12.6 0.0 1.2 1 0 0 1 1 1 0 Iron-containing alcohol dehydrogenase DUF4485 PF14846.6 CAV26317.1 - 0.1 12.7 0.2 0.12 12.5 0.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4485) Pyr_redox_2 PF07992.14 CAV26319.1 - 1.4e-53 182.1 1.0 2.3e-53 181.4 1.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Fer2_BFD PF04324.15 CAV26319.1 - 1.2e-20 73.6 2.1 2.2e-14 53.6 1.9 2.7 2 0 0 2 2 2 2 BFD-like [2Fe-2S] binding domain Pyr_redox PF00070.27 CAV26319.1 - 7.1e-15 55.3 6.3 1.1e-14 54.7 0.4 3.3 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NIR_SIR PF01077.22 CAV26319.1 - 1.5e-14 53.8 0.0 3.6e-14 52.6 0.0 1.6 1 0 0 1 1 1 1 Nitrite and sulphite reductase 4Fe-4S domain Rubredoxin_C PF18267.1 CAV26319.1 - 2.3e-13 49.8 0.3 9.3e-13 47.9 0.3 2.1 1 0 0 1 1 1 1 Rubredoxin NAD+ reductase C-terminal domain NIR_SIR_ferr PF03460.17 CAV26319.1 - 2.5e-12 46.4 0.1 1.2e-11 44.3 0.0 2.1 2 0 0 2 2 2 1 Nitrite/Sulfite reductase ferredoxin-like half domain Pyr_redox_3 PF13738.6 CAV26319.1 - 5.6e-08 32.4 0.0 9.1e-08 31.7 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 CAV26319.1 - 0.00064 18.9 0.9 0.24 10.5 0.7 2.4 2 0 0 2 2 2 2 Glucose inhibited division protein A FAD_binding_2 PF00890.24 CAV26319.1 - 0.0018 17.4 3.8 0.6 9.1 0.0 2.4 2 0 0 2 2 2 2 FAD binding domain NAD_binding_7 PF13241.6 CAV26319.1 - 0.0066 16.9 0.2 1.8 9.0 0.0 2.6 2 0 0 2 2 2 1 Putative NAD(P)-binding AlaDh_PNT_C PF01262.21 CAV26319.1 - 0.012 14.9 0.9 0.066 12.5 0.4 2.2 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain NAD_binding_9 PF13454.6 CAV26319.1 - 0.023 14.7 4.0 1.8 8.6 0.0 3.6 3 1 1 4 4 4 0 FAD-NAD(P)-binding K_oxygenase PF13434.6 CAV26319.1 - 0.031 13.4 0.0 0.12 11.5 0.0 1.8 2 0 0 2 2 2 0 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_dim PF02852.22 CAV26319.1 - 0.064 13.5 0.8 0.31 11.3 0.0 2.5 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain FAD_binding_3 PF01494.19 CAV26319.1 - 0.07 12.4 0.1 0.12 11.6 0.1 1.4 1 0 0 1 1 1 0 FAD binding domain HI0933_like PF03486.14 CAV26319.1 - 0.14 10.9 1.4 11 4.5 0.0 3.0 2 1 1 3 3 3 0 HI0933-like protein SO_alpha_A3 PF17806.1 CAV26319.1 - 0.16 12.3 0.0 0.55 10.6 0.0 1.9 1 0 0 1 1 1 0 Sarcosine oxidase A3 domain DAO PF01266.24 CAV26319.1 - 1.3 8.5 3.9 60 3.0 0.0 3.3 2 1 1 3 3 3 0 FAD dependent oxidoreductase Rieske_2 PF13806.6 CAV26321.1 - 9.3e-40 134.8 0.0 1e-39 134.6 0.0 1.0 1 0 0 1 1 1 1 Rieske-like [2Fe-2S] domain Form_Nir_trans PF01226.17 CAV26323.1 - 6.7e-58 195.8 27.5 7.7e-58 195.6 27.5 1.0 1 0 0 1 1 1 1 Formate/nitrite transporter TP_methylase PF00590.20 CAV26325.1 - 3.3e-49 167.7 0.0 4.2e-49 167.4 0.0 1.0 1 0 0 1 1 1 1 Tetrapyrrole (Corrin/Porphyrin) Methylases DUF4174 PF13778.6 CAV26327.1 - 2.5e-24 86.1 0.0 3.5e-24 85.6 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4174) NYN PF01936.18 CAV26328.1 - 4.9e-40 137.4 0.1 5.7e-40 137.2 0.1 1.0 1 0 0 1 1 1 1 NYN domain EFG_II PF14492.6 CAV26328.1 - 0.12 12.4 0.0 0.22 11.7 0.0 1.3 1 0 0 1 1 1 0 Elongation Factor G, domain II Response_reg PF00072.24 CAV26330.1 - 4.8e-29 100.8 0.0 7.8e-29 100.1 0.0 1.3 1 0 0 1 1 1 1 Response regulator receiver domain Trans_reg_C PF00486.28 CAV26330.1 - 2e-17 63.0 0.1 3.6e-17 62.2 0.1 1.3 1 0 0 1 1 1 1 Transcriptional regulatory protein, C terminal RTC PF01137.21 CAV26330.1 - 0.11 11.7 0.3 0.22 10.7 0.3 1.5 1 0 0 1 1 1 0 RNA 3'-terminal phosphate cyclase HK_sensor PF16750.5 CAV26332.1 - 2.3e-29 101.9 0.0 5.2e-29 100.7 0.0 1.7 1 0 0 1 1 1 1 Sensor domain of 2-component histidine kinase HATPase_c PF02518.26 CAV26332.1 - 2.2e-22 79.7 0.1 4.2e-22 78.8 0.1 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 CAV26332.1 - 1.2e-13 50.8 2.3 1.2e-13 50.8 2.3 2.1 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain HAMP PF00672.25 CAV26332.1 - 9.2e-07 29.2 0.1 2.3e-06 27.9 0.1 1.7 1 0 0 1 1 1 1 HAMP domain HATPase_c_3 PF13589.6 CAV26332.1 - 7.9e-06 25.7 0.2 2.1e-05 24.3 0.2 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DUF948 PF06103.11 CAV26332.1 - 0.00062 20.0 2.8 0.0016 18.7 0.2 2.8 3 1 0 3 3 3 1 Bacterial protein of unknown function (DUF948) DUF4446 PF14584.6 CAV26332.1 - 0.0074 16.3 1.2 0.012 15.6 0.1 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF4446) HATPase_c_5 PF14501.6 CAV26332.1 - 0.017 15.0 0.2 0.2 11.6 0.0 2.3 2 0 0 2 2 2 0 GHKL domain BRE1 PF08647.11 CAV26332.1 - 0.11 12.6 0.8 0.48 10.5 0.8 2.1 1 1 0 1 1 1 0 BRE1 E3 ubiquitin ligase TolA_bind_tri PF16331.5 CAV26332.1 - 1.4 9.0 8.2 0.26 11.4 0.5 3.1 3 0 0 3 3 3 0 TolA binding protein trimerisation SDF PF00375.18 CAV26334.1 - 5.1e-130 434.0 41.7 5.7e-130 433.8 41.7 1.0 1 0 0 1 1 1 1 Sodium:dicarboxylate symporter family TonB_dep_Rec PF00593.24 CAV26336.1 - 3.9e-49 168.8 25.5 3.9e-49 168.8 25.5 1.7 1 1 0 1 1 1 1 TonB dependent receptor Plug PF07715.15 CAV26336.1 - 4.1e-18 65.9 0.0 9.8e-18 64.7 0.0 1.7 1 0 0 1 1 1 1 TonB-dependent Receptor Plug Domain DUF3450 PF11932.8 CAV26338.1 - 3.5e-87 291.7 11.8 3.9e-87 291.6 11.8 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3450) DUF641 PF04859.12 CAV26338.1 - 0.075 13.4 5.4 0.055 13.8 2.1 2.2 2 0 0 2 2 2 0 Plant protein of unknown function (DUF641) Ribosomal_S25 PF03297.15 CAV26338.1 - 0.078 13.2 0.3 0.078 13.2 0.3 1.7 2 0 0 2 2 2 0 S25 ribosomal protein MotA_ExbB PF01618.16 CAV26340.1 - 5.3e-31 107.0 3.2 5.3e-31 107.0 3.2 2.1 2 1 1 3 3 3 1 MotA/TolQ/ExbB proton channel family Uso1_p115_C PF04871.13 CAV26340.1 - 0.0055 17.1 2.5 0.0055 17.1 2.5 1.9 2 0 0 2 2 2 1 Uso1 / p115 like vesicle tethering protein, C terminal region PepSY_TM PF03929.16 CAV26340.1 - 0.0084 15.8 0.0 0.0084 15.8 0.0 2.2 3 0 0 3 3 3 1 PepSY-associated TM region Med9 PF07544.13 CAV26340.1 - 0.033 14.3 1.8 0.11 12.6 1.8 1.9 1 0 0 1 1 1 0 RNA polymerase II transcription mediator complex subunit 9 DUF4200 PF13863.6 CAV26340.1 - 0.092 13.1 3.0 0.21 12.0 3.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4200) MotA_ExbB PF01618.16 CAV26341.1 - 8.2e-23 80.5 0.1 1e-22 80.2 0.1 1.1 1 0 0 1 1 1 1 MotA/TolQ/ExbB proton channel family HemY_N PF07219.13 CAV26341.1 - 0.3 11.3 6.1 0.14 12.4 2.1 2.1 2 1 0 2 2 2 0 HemY protein N-terminus ExbD PF02472.16 CAV26343.1 - 1.5e-28 99.6 1.6 1.6e-28 99.5 1.6 1.0 1 0 0 1 1 1 1 Biopolymer transport protein ExbD/TolR TonB_C PF03544.14 CAV26345.1 - 1.3e-20 73.6 0.1 2.2e-20 72.9 0.1 1.4 1 0 0 1 1 1 1 Gram-negative bacterial TonB protein C-terminal Oleosin PF01277.17 CAV26345.1 - 0.031 14.0 0.0 0.24 11.2 0.0 2.0 2 0 0 2 2 2 0 Oleosin TonB_2 PF13103.6 CAV26345.1 - 0.13 12.5 1.2 0.47 10.7 0.0 2.1 2 0 0 2 2 2 0 TonB C terminal ANAPC3 PF12895.7 CAV26347.1 - 8.5e-08 32.3 12.2 0.00069 19.8 0.6 5.0 1 1 5 6 6 6 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.6 CAV26347.1 - 9e-08 32.5 20.9 0.061 13.8 1.1 6.2 3 3 3 7 7 7 4 Tetratricopeptide repeat BTAD PF03704.17 CAV26347.1 - 8.3e-06 26.3 1.2 0.00028 21.4 0.0 3.0 2 1 0 2 2 2 1 Bacterial transcriptional activator domain TPR_14 PF13428.6 CAV26347.1 - 1.5e-05 25.4 18.8 0.78 10.7 0.2 8.0 5 4 3 8 8 8 1 Tetratricopeptide repeat TPR_16 PF13432.6 CAV26347.1 - 1.8e-05 25.3 12.4 2.5 8.8 0.0 5.6 4 2 2 6 6 6 1 Tetratricopeptide repeat TPR_2 PF07719.17 CAV26347.1 - 0.00015 21.6 15.7 3 8.2 0.1 8.0 9 0 0 9 9 9 1 Tetratricopeptide repeat TPR_9 PF13371.6 CAV26347.1 - 0.00047 20.2 7.5 7.8 6.7 0.0 4.9 4 1 1 5 5 5 1 Tetratricopeptide repeat TPR_8 PF13181.6 CAV26347.1 - 0.00086 19.3 3.8 33 5.0 0.0 5.9 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_7 PF13176.6 CAV26347.1 - 0.001 19.0 3.4 5.9 7.2 0.0 5.4 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_4 PF07721.14 CAV26347.1 - 0.0026 18.2 0.4 17 6.4 0.0 4.6 4 0 0 4 4 4 0 Tetratricopeptide repeat DUF3760 PF12586.8 CAV26347.1 - 0.08 13.1 0.0 0.19 11.9 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3760) TPR_12 PF13424.6 CAV26347.1 - 0.18 12.1 7.7 2.7 8.3 0.0 5.0 4 2 2 6 6 6 0 Tetratricopeptide repeat SPC22 PF04573.12 CAV26347.1 - 0.18 11.3 6.7 0.5 9.8 6.7 1.7 1 1 0 1 1 1 0 Signal peptidase subunit SRP_TPR_like PF17004.5 CAV26347.1 - 0.27 11.2 8.8 0.82 9.7 2.1 3.8 3 1 0 3 3 3 0 Putative TPR-like repeat TPR_18 PF13512.6 CAV26347.1 - 0.6 10.2 4.5 0.63 10.2 0.1 3.0 3 2 0 3 3 3 0 Tetratricopeptide repeat DUF1459 PF07312.11 CAV26349.1 - 0.0098 16.1 0.1 0.013 15.7 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1459) PepSY_TM_like_2 PF16357.5 CAV26350.1 - 2.6e-58 197.2 0.2 3e-58 197.1 0.2 1.0 1 0 0 1 1 1 1 Putative PepSY_TM-like PepSY_TM PF03929.16 CAV26350.1 - 2.4e-12 47.1 0.6 2.7e-11 43.7 0.2 2.0 1 1 0 1 1 1 1 PepSY-associated TM region DUF4079 PF13301.6 CAV26350.1 - 0.043 14.0 1.6 0.084 13.0 0.3 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF4079) MotB_plug PF13677.6 CAV26350.1 - 8.9 6.0 6.2 0.85 9.3 0.1 2.1 2 0 0 2 2 2 0 Membrane MotB of proton-channel complex MotA/MotB DUF2271 PF10029.9 CAV26352.1 - 4.6e-46 155.8 2.7 5.4e-46 155.6 2.7 1.0 1 0 0 1 1 1 1 Predicted periplasmic protein (DUF2271) FlgD_ig PF13860.6 CAV26352.1 - 1.6e-09 37.5 0.3 8.5e-09 35.2 0.1 2.2 3 0 0 3 3 3 1 FlgD Ig-like domain POTRA_TamA_1 PF17243.2 CAV26352.1 - 0.00038 20.5 0.0 0.0006 19.9 0.0 1.3 1 0 0 1 1 1 1 POTRA domain TamA domain 1 DUF4198 PF10670.9 CAV26354.1 - 6.2e-46 157.4 0.9 7.2e-46 157.2 0.9 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4198) Filamin PF00630.19 CAV26354.1 - 0.09 13.6 0.6 0.88 10.4 0.2 2.2 2 0 0 2 2 2 0 Filamin/ABP280 repeat bMG3 PF11974.8 CAV26356.1 - 0.12 12.4 0.0 0.14 12.2 0.0 1.2 1 0 0 1 1 1 0 Bacterial alpha-2-macroglobulin MG3 domain ZnuA PF01297.17 CAV26360.1 - 2.5e-44 151.6 0.1 3.1e-44 151.3 0.1 1.0 1 0 0 1 1 1 1 Zinc-uptake complex component A periplasmic ABC_tran PF00005.27 CAV26361.1 - 1e-24 87.6 0.0 1.6e-24 87.0 0.0 1.3 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 CAV26361.1 - 2.2e-07 31.0 0.4 0.014 15.2 0.0 2.2 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 CAV26361.1 - 9.9e-06 25.1 0.1 0.06 12.8 0.0 2.1 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain SbcCD_C PF13558.6 CAV26361.1 - 7.7e-05 22.8 0.1 0.0024 18.0 0.1 2.5 1 1 0 1 1 1 1 Putative exonuclease SbcCD, C subunit AAA_27 PF13514.6 CAV26361.1 - 0.0072 15.9 0.0 0.014 15.0 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_23 PF13476.6 CAV26361.1 - 0.014 15.9 0.0 0.023 15.2 0.0 1.2 1 0 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 CAV26361.1 - 0.056 13.3 0.1 0.2 11.5 0.0 1.8 2 0 0 2 2 2 0 RsgA GTPase IstB_IS21 PF01695.17 CAV26361.1 - 0.07 12.9 0.2 1.9 8.2 0.0 2.4 3 0 0 3 3 3 0 IstB-like ATP binding protein AAA_16 PF13191.6 CAV26361.1 - 0.099 13.0 0.0 0.16 12.4 0.0 1.5 1 1 0 1 1 1 0 AAA ATPase domain AAA_29 PF13555.6 CAV26361.1 - 0.11 12.3 0.0 0.21 11.4 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain ABC-3 PF00950.17 CAV26363.1 - 5.5e-55 186.7 28.9 6.3e-55 186.5 28.9 1.0 1 0 0 1 1 1 1 ABC 3 transport family FecCD PF01032.18 CAV26363.1 - 2.5e-08 33.3 29.5 2.5e-08 33.3 29.5 1.8 1 1 1 2 2 2 1 FecCD transport family PAP2 PF01569.21 CAV26363.1 - 2.6 7.8 14.5 0.6 9.9 2.6 3.6 2 2 2 4 4 4 0 PAP2 superfamily DUF3290 PF11694.8 CAV26363.1 - 4.1 7.4 5.4 0.55 10.2 0.6 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3290) MPS-4 PF17523.2 CAV26363.1 - 9.4 6.4 10.9 0.49 10.6 1.1 3.0 3 0 0 3 3 3 0 MinK-related peptide, potassium channel accessory sub-unit protein 4 ZnuA PF01297.17 CAV26365.1 - 0.0045 16.4 0.2 0.0081 15.6 0.2 1.5 1 1 0 1 1 1 1 Zinc-uptake complex component A periplasmic DUF2986 PF11661.8 CAV26367.1 - 1.9e-22 79.5 12.1 3.2e-22 78.8 12.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2986) CUE PF02845.16 CAV26367.1 - 0.077 12.7 0.1 0.12 12.2 0.1 1.3 1 0 0 1 1 1 0 CUE domain ATP-synt_B PF00430.18 CAV26367.1 - 1.1 9.4 15.1 4.7 7.3 15.1 1.7 1 1 0 1 1 1 0 ATP synthase B/B' CF(0) Acetyltransf_3 PF13302.7 CAV26369.1 - 7e-22 78.6 0.0 8.1e-22 78.4 0.0 1.0 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 CAV26369.1 - 4.2e-09 36.6 0.0 5.2e-09 36.4 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_4 PF13420.7 CAV26369.1 - 2.1e-07 31.2 0.0 3.5e-07 30.5 0.0 1.3 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 CAV26369.1 - 0.0012 18.8 0.0 0.003 17.5 0.0 1.6 2 0 0 2 2 2 1 FR47-like protein SdiA-regulated PF06977.11 CAV26369.1 - 0.026 13.8 0.1 0.058 12.6 0.0 1.5 2 0 0 2 2 2 0 SdiA-regulated YgbA_NO PF11756.8 CAV26370.1 - 1.5e-45 153.9 5.1 1.8e-45 153.7 5.1 1.1 1 0 0 1 1 1 1 Nitrous oxide-stimulated promoter MatE PF01554.18 CAV26372.1 - 4.5e-38 130.4 41.9 2e-23 82.9 14.1 2.5 3 0 0 3 3 3 2 MatE Polysacc_synt_C PF14667.6 CAV26372.1 - 0.00017 21.7 20.9 0.00017 21.7 20.9 4.3 1 1 2 3 3 3 1 Polysaccharide biosynthesis C-terminal domain HTH_18 PF12833.7 CAV26374.1 - 4.7e-20 71.6 0.3 3.3e-19 68.9 0.1 2.0 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_AraC PF00165.23 CAV26374.1 - 1.1e-18 66.8 0.2 6.4e-12 45.2 0.1 2.5 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family Trans_reg_C PF00486.28 CAV26376.1 - 1.9e-09 37.5 0.1 3.3e-09 36.7 0.1 1.4 1 0 0 1 1 1 1 Transcriptional regulatory protein, C terminal GXWXG PF14231.6 CAV26376.1 - 0.18 11.9 0.0 0.4 10.8 0.0 1.6 2 0 0 2 2 2 0 GXWXG protein Trans_reg_C PF00486.28 CAV26377.1 - 2.9e-06 27.3 0.0 5.9e-06 26.3 0.0 1.5 2 0 0 2 2 2 1 Transcriptional regulatory protein, C terminal MFS_1 PF07690.16 CAV26379.1 - 1.9e-22 79.7 42.4 1.9e-22 79.7 42.4 1.5 1 1 0 1 1 1 1 Major Facilitator Superfamily MFS_4 PF06779.14 CAV26379.1 - 1.4e-15 57.5 29.0 6.2e-15 55.4 29.0 2.2 1 1 0 1 1 1 1 Uncharacterised MFS-type transporter YbfB CRM1_repeat_3 PF18787.1 CAV26379.1 - 0.15 12.2 0.0 0.58 10.3 0.0 1.9 2 0 0 2 2 2 0 CRM1 / Exportin repeat 3 TMEM40 PF15817.5 CAV26379.1 - 0.86 9.4 7.5 0.11 12.2 0.4 2.4 2 0 0 2 2 2 0 Transmembrane protein 40 family DUF1118 PF06549.12 CAV26379.1 - 3.9 7.8 6.2 1.2 9.5 1.0 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF1118) GlgS PF08971.11 CAV26381.1 - 0.038 14.0 0.0 0.086 12.9 0.0 1.6 1 0 0 1 1 1 0 Glycogen synthesis protein GMC_oxred_N PF00732.19 CAV26382.1 - 9.3e-91 304.3 0.0 1.3e-90 303.8 0.0 1.2 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 CAV26382.1 - 7e-42 143.4 0.0 1.2e-41 142.5 0.0 1.4 1 0 0 1 1 1 1 GMC oxidoreductase Lycopene_cycl PF05834.12 CAV26382.1 - 1.6e-05 24.2 0.1 2.5e-05 23.5 0.1 1.3 1 0 0 1 1 1 1 Lycopene cyclase protein DAO PF01266.24 CAV26382.1 - 0.0003 20.5 1.4 0.0029 17.3 1.4 2.3 1 1 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 CAV26382.1 - 0.001 19.2 0.7 0.0024 18.1 0.1 1.9 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 CAV26382.1 - 0.0018 17.5 0.3 0.012 14.7 0.1 2.0 2 0 0 2 2 2 1 FAD binding domain Pyr_redox_2 PF07992.14 CAV26382.1 - 0.0047 16.2 0.0 0.04 13.1 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 CAV26382.1 - 0.0048 16.2 0.1 0.0084 15.4 0.1 1.4 1 0 0 1 1 1 1 Thi4 family HI0933_like PF03486.14 CAV26382.1 - 0.035 12.8 0.1 0.07 11.8 0.0 1.5 2 0 0 2 2 2 0 HI0933-like protein GIDA PF01134.22 CAV26382.1 - 0.076 12.1 0.3 0.79 8.7 0.2 2.1 2 0 0 2 2 2 0 Glucose inhibited division protein A EAR PF07897.11 CAV26382.1 - 0.096 12.3 0.1 0.18 11.4 0.1 1.5 1 0 0 1 1 1 0 Ethylene-responsive binding factor-associated repression Pyr_redox_3 PF13738.6 CAV26382.1 - 0.11 11.7 0.4 13 4.9 0.2 2.4 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Thioredoxin PF00085.20 CAV26384.1 - 3.3e-28 97.7 0.5 3.2e-27 94.5 0.0 2.1 2 0 0 2 2 2 1 Thioredoxin Thioredoxin_2 PF13098.6 CAV26384.1 - 5.5e-11 42.9 0.1 5.5e-11 42.9 0.1 2.4 3 1 0 3 3 2 1 Thioredoxin-like domain Thioredoxin_8 PF13905.6 CAV26384.1 - 1.8e-07 31.4 0.1 0.0058 16.9 0.0 2.4 1 1 1 2 2 2 2 Thioredoxin-like OST3_OST6 PF04756.13 CAV26384.1 - 4.4e-06 26.3 0.0 5e-06 26.1 0.0 1.1 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family Thioredoxin_7 PF13899.6 CAV26384.1 - 8.4e-05 22.7 2.3 8.6e-05 22.7 0.2 2.0 3 0 0 3 3 2 1 Thioredoxin-like Redoxin PF08534.10 CAV26384.1 - 0.00092 18.9 0.3 0.0063 16.2 0.3 2.0 1 1 1 2 2 2 1 Redoxin Thioredoxin_9 PF14595.6 CAV26384.1 - 0.0019 18.0 0.0 0.0023 17.7 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin HyaE PF07449.11 CAV26384.1 - 0.01 15.8 0.0 0.014 15.3 0.0 1.3 1 0 0 1 1 1 0 Hydrogenase-1 expression protein HyaE Thioredoxin_3 PF13192.6 CAV26384.1 - 0.014 15.5 4.1 0.041 13.9 0.0 2.8 2 1 1 3 3 3 0 Thioredoxin domain DUF953 PF06110.11 CAV26384.1 - 0.021 14.4 1.8 0.039 13.6 0.1 2.2 2 1 0 2 2 2 0 Eukaryotic protein of unknown function (DUF953) Anti-TRAP PF15777.5 CAV26384.1 - 0.036 14.0 1.2 0.076 13.0 1.2 1.5 1 0 0 1 1 1 0 Tryptophan RNA-binding attenuator protein inhibitory protein zinc_ribbon_4 PF13717.6 CAV26384.1 - 0.04 13.9 3.6 0.11 12.5 3.6 1.7 1 1 0 1 1 1 0 zinc-ribbon domain Thioredoxin_6 PF13848.6 CAV26384.1 - 0.043 13.7 0.0 0.054 13.4 0.0 1.2 1 0 0 1 1 1 0 Thioredoxin-like domain DUF393 PF04134.12 CAV26384.1 - 0.11 13.8 0.1 1.7 10.0 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function, DUF393 DIM1 PF02966.16 CAV26384.1 - 0.12 12.2 0.0 0.14 11.9 0.0 1.1 1 0 0 1 1 1 0 Mitosis protein DIM1 DUF1272 PF06906.11 CAV26384.1 - 0.12 12.5 1.5 28 4.9 0.0 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF1272) Glutaredoxin PF00462.24 CAV26384.1 - 0.18 12.1 5.5 1.2 9.4 0.4 3.2 3 1 0 3 3 3 0 Glutaredoxin ACP_syn_III_C PF08541.10 CAV26385.1 - 1.7e-34 117.8 0.4 6.2e-33 112.8 0.0 2.8 3 0 0 3 3 3 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal ACP_syn_III PF08545.10 CAV26385.1 - 6.6e-28 96.4 0.4 6.6e-28 96.4 0.4 1.8 2 0 0 2 2 2 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III Thiolase_N PF00108.23 CAV26385.1 - 5.7e-09 35.7 3.9 6.7e-09 35.5 0.5 2.3 2 1 1 3 3 3 1 Thiolase, N-terminal domain FAE1_CUT1_RppA PF08392.12 CAV26385.1 - 3.4e-05 23.3 0.1 0.00056 19.3 0.0 2.0 2 0 0 2 2 2 1 FAE1/Type III polyketide synthase-like protein ketoacyl-synt PF00109.26 CAV26385.1 - 0.02 14.5 3.2 14 5.2 0.1 3.1 1 1 2 3 3 3 0 Beta-ketoacyl synthase, N-terminal domain StbA PF06406.11 CAV26385.1 - 0.13 11.4 0.0 0.69 9.1 0.0 1.9 2 0 0 2 2 2 0 StbA protein Glyco_trans_1_4 PF13692.6 CAV26387.1 - 4e-20 72.6 0.0 6.1e-20 72.0 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glycos_transf_1 PF00534.20 CAV26387.1 - 0.0029 17.1 0.0 0.0053 16.3 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 PP_kinase PF02503.17 CAV26387.1 - 0.03 13.9 0.2 0.047 13.3 0.2 1.2 1 0 0 1 1 1 0 Polyphosphate kinase middle domain Sulf_transp PF04143.14 CAV26389.1 - 4.1e-10 39.7 12.7 7.6e-10 38.8 12.7 1.6 1 1 0 1 1 1 1 Sulphur transport DUF1345 PF07077.11 CAV26389.1 - 0.053 13.2 0.1 0.16 11.6 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1345) HupE_UreJ PF04955.12 CAV26389.1 - 0.24 10.9 10.0 0.015 14.7 3.9 2.1 2 1 0 2 2 2 0 HupE / UreJ protein Sulf_transp PF04143.14 CAV26391.1 - 2.6e-05 23.9 14.9 4.5e-05 23.2 3.4 2.3 2 1 0 2 2 2 2 Sulphur transport Exo_endo_phos PF03372.23 CAV26393.1 - 7.9e-10 38.6 2.4 2.3e-09 37.1 2.4 1.8 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family AftA_C PF12249.8 CAV26393.1 - 0.01 15.5 2.1 0.63 9.7 0.1 2.1 2 0 0 2 2 2 0 Arabinofuranosyltransferase A C terminal NRDD PF13597.6 CAV26396.2 - 8.8e-181 602.5 0.3 1e-180 602.2 0.3 1.1 1 0 0 1 1 1 1 Anaerobic ribonucleoside-triphosphate reductase Gly_radical PF01228.21 CAV26396.2 - 1.3e-27 96.4 0.0 4.9e-27 94.6 0.0 2.1 2 0 0 2 2 2 1 Glycine radical ATP-cone PF03477.16 CAV26396.2 - 6.2e-24 84.4 3.0 1.1e-21 77.1 1.3 2.7 2 0 0 2 2 2 2 ATP cone domain OrfB_Zn_ribbon PF07282.11 CAV26396.2 - 0.11 12.4 2.2 0.4 10.6 2.2 1.9 1 0 0 1 1 1 0 Putative transposase DNA-binding domain Zn_Tnp_IS91 PF14319.6 CAV26396.2 - 0.13 12.3 0.6 0.32 11.0 0.6 1.6 1 0 0 1 1 1 0 Transposase zinc-binding domain HypA PF01155.19 CAV26396.2 - 0.23 11.5 2.0 0.84 9.7 2.0 1.9 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA ribosomal_L24 PF17136.4 CAV26396.2 - 0.25 11.8 2.2 2.7 8.4 0.0 3.1 3 0 0 3 3 3 0 Ribosomal proteins 50S L24/mitochondrial 39S L24 Zn_Tnp_IS1595 PF12760.7 CAV26396.2 - 2.8 8.0 7.1 0.55 10.2 0.7 2.8 3 0 0 3 3 3 0 Transposase zinc-ribbon domain Fer4_12 PF13353.6 CAV26398.1 - 3.8e-51 173.0 0.0 4.3e-51 172.9 0.0 1.0 1 0 0 1 1 1 1 4Fe-4S single cluster domain Fer4_14 PF13394.6 CAV26398.1 - 6.8e-33 113.3 0.0 8.5e-33 113.0 0.0 1.1 1 0 0 1 1 1 1 4Fe-4S single cluster domain Radical_SAM PF04055.21 CAV26398.1 - 0.00057 20.3 0.0 0.00067 20.1 0.0 1.2 1 0 0 1 1 1 1 Radical SAM superfamily MatE PF01554.18 CAV26400.1 - 6.6e-48 162.4 31.2 3e-30 105.0 10.8 2.5 2 0 0 2 2 2 2 MatE Polysacc_synt_C PF14667.6 CAV26400.1 - 9.4e-11 42.0 12.9 9.4e-11 42.0 12.9 4.2 2 2 2 4 4 4 1 Polysaccharide biosynthesis C-terminal domain DUF1731 PF08338.11 CAV26400.1 - 0.14 12.0 0.0 0.48 10.3 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF1731) HTH_18 PF12833.7 CAV26402.1 - 3.6e-19 68.8 0.1 8e-19 67.7 0.1 1.6 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 CAV26402.1 - 4.2e-13 49.0 0.1 4.1e-07 29.9 0.0 2.5 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family AraC_binding PF02311.19 CAV26402.1 - 1.8e-05 24.7 0.2 0.00016 21.6 0.0 2.3 1 1 1 2 2 2 1 AraC-like ligand binding domain Cupin_2 PF07883.11 CAV26402.1 - 0.0041 16.8 0.0 0.0088 15.7 0.0 1.6 1 0 0 1 1 1 1 Cupin domain Aminotran_1_2 PF00155.21 CAV26403.1 - 1.1e-67 228.8 0.0 1.2e-67 228.6 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Zn_protease PF05618.11 CAV26405.1 - 4.7e-42 143.1 0.1 6.3e-42 142.7 0.1 1.2 1 0 0 1 1 1 1 Putative ATP-dependant zinc protease gag-asp_proteas PF13975.6 CAV26405.1 - 4.7e-05 23.9 0.2 0.0019 18.7 0.2 2.3 1 1 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 CAV26405.1 - 0.011 16.4 0.1 4.8 7.9 0.0 2.3 2 0 0 2 2 2 0 Aspartyl protease Trypan_PARP PF05887.11 CAV26405.1 - 0.84 9.6 13.2 1.4 8.9 13.2 1.3 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) ABC_tran PF00005.27 CAV26407.1 - 5.8e-42 143.4 0.1 2.2e-20 73.6 0.0 3.1 3 0 0 3 3 3 2 ABC transporter ABC_tran_Xtn PF12848.7 CAV26407.1 - 1.9e-23 82.3 0.2 8.4e-21 73.8 0.0 2.3 2 0 0 2 2 2 1 ABC transporter AAA_21 PF13304.6 CAV26407.1 - 4.7e-18 66.0 1.6 0.00051 19.9 0.1 4.5 5 0 0 5 5 4 4 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 CAV26407.1 - 4e-09 36.2 3.1 0.21 11.0 0.0 4.2 4 0 0 4 4 4 3 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 CAV26407.1 - 1.8e-07 31.9 0.4 0.0061 17.1 0.0 2.6 3 0 0 3 3 2 2 AAA domain RNA_helicase PF00910.22 CAV26407.1 - 6.1e-07 29.8 0.0 0.021 15.2 0.0 2.8 2 0 0 2 2 2 2 RNA helicase NACHT PF05729.12 CAV26407.1 - 1.8e-06 28.0 0.3 0.0018 18.2 0.0 2.6 2 0 0 2 2 2 1 NACHT domain AAA_29 PF13555.6 CAV26407.1 - 6.3e-06 25.8 0.7 0.058 13.1 0.1 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_16 PF13191.6 CAV26407.1 - 7.7e-06 26.4 0.0 0.0011 19.3 0.0 2.6 2 0 0 2 2 2 1 AAA ATPase domain AAA_18 PF13238.6 CAV26407.1 - 8.5e-06 26.3 0.2 0.13 12.8 0.0 3.3 2 1 1 3 3 3 2 AAA domain RsgA_GTPase PF03193.16 CAV26407.1 - 9e-06 25.7 0.5 0.023 14.6 0.1 2.5 2 0 0 2 2 2 2 RsgA GTPase AAA_22 PF13401.6 CAV26407.1 - 1.6e-05 25.2 4.3 0.00045 20.5 0.1 3.3 3 1 0 3 3 3 1 AAA domain MMR_HSR1 PF01926.23 CAV26407.1 - 2.2e-05 24.5 0.1 0.26 11.4 0.2 3.0 2 1 0 2 2 2 2 50S ribosome-binding GTPase MeaB PF03308.16 CAV26407.1 - 2.2e-05 23.6 0.8 0.004 16.2 0.0 2.8 3 0 0 3 3 3 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA PF00004.29 CAV26407.1 - 4.1e-05 24.0 0.3 0.19 12.2 0.0 3.8 4 0 0 4 4 4 1 ATPase family associated with various cellular activities (AAA) AAA_24 PF13479.6 CAV26407.1 - 7.9e-05 22.5 0.1 0.16 11.6 0.0 2.8 3 0 0 3 3 2 2 AAA domain AAA_15 PF13175.6 CAV26407.1 - 0.00018 21.3 6.9 0.028 14.1 0.0 3.1 4 1 0 4 4 2 2 AAA ATPase domain Rad17 PF03215.15 CAV26407.1 - 0.00027 20.9 0.1 0.61 10.0 0.1 2.6 2 0 0 2 2 2 2 Rad17 P-loop domain AAA_14 PF13173.6 CAV26407.1 - 0.00044 20.3 0.1 0.96 9.5 0.0 3.9 5 0 0 5 5 4 1 AAA domain AAA_28 PF13521.6 CAV26407.1 - 0.00051 20.3 0.0 1.6 8.9 0.0 3.0 3 0 0 3 3 3 1 AAA domain MobB PF03205.14 CAV26407.1 - 0.00069 19.5 0.1 0.04 13.8 0.0 2.7 3 0 0 3 3 2 1 Molybdopterin guanine dinucleotide synthesis protein B ATP-synt_ab PF00006.25 CAV26407.1 - 0.0012 18.5 0.2 2.1 8.0 0.0 2.4 2 1 0 2 2 2 2 ATP synthase alpha/beta family, nucleotide-binding domain AAA_33 PF13671.6 CAV26407.1 - 0.0016 18.6 0.0 1.6 8.9 0.0 2.5 2 0 0 2 2 2 1 AAA domain DUF87 PF01935.17 CAV26407.1 - 0.0025 17.9 1.5 0.26 11.3 0.0 3.0 3 0 0 3 3 2 1 Helicase HerA, central domain AAA_30 PF13604.6 CAV26407.1 - 0.0027 17.4 1.9 0.58 9.8 0.0 3.3 4 1 0 4 4 4 1 AAA domain AAA_7 PF12775.7 CAV26407.1 - 0.0029 17.1 0.5 0.14 11.7 0.0 2.5 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_5 PF07728.14 CAV26407.1 - 0.003 17.6 0.5 2.5 8.1 0.1 3.0 3 0 0 3 3 2 1 AAA domain (dynein-related subfamily) TsaE PF02367.17 CAV26407.1 - 0.0033 17.4 0.6 0.37 10.8 0.2 2.5 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE Roc PF08477.13 CAV26407.1 - 0.0054 16.9 0.1 0.12 12.6 0.0 2.6 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Septin PF00735.18 CAV26407.1 - 0.0062 15.9 0.2 0.17 11.1 0.0 2.3 2 0 0 2 2 2 1 Septin NB-ARC PF00931.22 CAV26407.1 - 0.0079 15.4 1.0 0.1 11.8 0.1 2.4 2 0 0 2 2 2 1 NB-ARC domain Pox_A32 PF04665.12 CAV26407.1 - 0.016 14.7 0.9 0.15 11.5 0.0 2.3 2 0 0 2 2 2 0 Poxvirus A32 protein dNK PF01712.19 CAV26407.1 - 0.018 14.9 0.5 2.9 7.7 0.0 2.7 2 0 0 2 2 2 0 Deoxynucleoside kinase GcpE PF04551.14 CAV26407.1 - 0.019 14.1 0.0 0.028 13.5 0.0 1.2 1 0 0 1 1 1 0 GcpE protein NTPase_1 PF03266.15 CAV26407.1 - 0.021 14.7 4.7 0.16 11.9 0.1 3.4 4 0 0 4 4 3 0 NTPase AAA_25 PF13481.6 CAV26407.1 - 0.027 14.1 0.8 2.5 7.6 0.0 2.8 3 0 0 3 3 3 0 AAA domain ATPase_2 PF01637.18 CAV26407.1 - 0.027 14.4 0.1 1 9.2 0.0 2.6 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea SbcCD_C PF13558.6 CAV26407.1 - 0.035 14.3 0.5 14 6.0 0.1 3.6 3 1 0 3 3 2 0 Putative exonuclease SbcCD, C subunit PduV-EutP PF10662.9 CAV26407.1 - 0.036 13.8 0.4 3.9 7.2 0.1 2.6 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation KAP_NTPase PF07693.14 CAV26407.1 - 0.037 13.3 0.0 1 8.5 0.0 2.3 2 0 0 2 2 2 0 KAP family P-loop domain Zeta_toxin PF06414.12 CAV26407.1 - 0.048 12.9 0.1 5.1 6.3 0.0 2.3 2 0 0 2 2 2 0 Zeta toxin SRP54 PF00448.22 CAV26407.1 - 0.065 12.9 1.1 3.9 7.1 0.1 3.2 3 0 0 3 3 3 0 SRP54-type protein, GTPase domain AAA_13 PF13166.6 CAV26407.1 - 0.067 11.8 0.7 5.3 5.6 0.0 2.6 3 0 0 3 3 3 0 AAA domain Ras PF00071.22 CAV26407.1 - 0.074 12.6 0.1 1.1 8.9 0.0 2.4 2 0 0 2 2 2 0 Ras family ATP_bind_1 PF03029.17 CAV26407.1 - 0.075 12.8 1.0 6.1 6.5 0.0 2.7 3 0 0 3 3 2 0 Conserved hypothetical ATP binding protein Thymidylate_kin PF02223.17 CAV26407.1 - 0.084 12.5 0.1 7.8 6.1 0.0 2.7 2 0 0 2 2 2 0 Thymidylate kinase CLP1_P PF16575.5 CAV26407.1 - 0.086 12.6 0.4 8.6 6.1 0.1 2.4 2 0 0 2 2 2 0 mRNA cleavage and polyadenylation factor CLP1 P-loop FeoB_N PF02421.18 CAV26407.1 - 0.095 12.2 0.1 18 4.8 0.0 2.5 2 0 0 2 2 2 0 Ferrous iron transport protein B DUF815 PF05673.13 CAV26407.1 - 0.12 11.5 0.8 15 4.6 0.1 2.6 3 0 0 3 3 2 0 Protein of unknown function (DUF815) AAA_19 PF13245.6 CAV26407.1 - 0.23 11.8 3.4 0.28 11.5 0.0 2.7 4 0 0 4 4 2 0 AAA domain T2SSE PF00437.20 CAV26407.1 - 0.4 9.7 3.1 1.9 7.5 0.0 2.9 3 0 0 3 3 3 0 Type II/IV secretion system protein MCPsignal PF00015.21 CAV26409.1 - 1.2e-43 148.9 39.7 1.7e-40 138.6 23.4 2.6 1 1 1 2 2 2 2 Methyl-accepting chemotaxis protein (MCP) signalling domain dCache_1 PF02743.18 CAV26409.1 - 3.4e-24 86.0 1.8 3.4e-24 86.0 1.8 4.1 2 1 1 3 3 3 1 Cache domain HAMP PF00672.25 CAV26409.1 - 1.5e-15 57.3 1.2 3.4e-12 46.6 0.0 4.2 4 0 0 4 4 4 1 HAMP domain Pro_Al_protease PF02983.14 CAV26409.1 - 0.019 15.0 2.6 0.14 12.3 0.3 3.1 3 0 0 3 3 3 0 Alpha-lytic protease prodomain DUF948 PF06103.11 CAV26409.1 - 0.69 10.2 35.2 1.1 9.6 3.6 6.1 3 2 2 5 5 5 0 Bacterial protein of unknown function (DUF948) BLOC1_2 PF10046.9 CAV26409.1 - 1.4 9.2 26.8 1.6 9.1 0.7 5.6 3 2 1 5 5 5 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 GARP PF16731.5 CAV26409.1 - 2.3 7.9 23.4 2.8 7.6 6.0 3.1 2 1 1 3 3 3 0 Glutamic acid/alanine-rich protein of Trypanosoma Alanine_zipper PF11839.8 CAV26409.1 - 6.1 7.3 22.5 0.48 10.8 3.1 3.7 3 0 0 3 3 3 0 Alanine-zipper, major outer membrane lipoprotein Mobilization_B PF17511.2 CAV26409.1 - 6.9 7.0 20.1 9.4 6.6 6.2 3.6 2 2 0 2 2 2 0 Mobilization protein B BOF PF04076.13 CAV26413.1 - 1.1e-09 38.2 0.3 1.4e-09 37.9 0.3 1.2 1 0 0 1 1 1 1 Bacterial OB fold (BOF) protein GATase_3 PF07685.14 CAV26414.1 - 1e-59 201.5 0.1 1.4e-59 201.0 0.1 1.2 1 0 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain AAA_26 PF13500.6 CAV26414.1 - 1.3e-22 80.6 0.0 3.5e-22 79.2 0.0 1.7 1 1 0 1 1 1 1 AAA domain CbiA PF01656.23 CAV26414.1 - 1.8e-22 79.8 0.0 3.8e-22 78.7 0.0 1.5 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain BPL_N PF09825.9 CAV26414.1 - 0.077 12.1 0.0 0.12 11.4 0.0 1.2 1 0 0 1 1 1 0 Biotin-protein ligase, N terminal MobB PF03205.14 CAV26414.1 - 0.093 12.6 0.0 0.26 11.2 0.0 1.8 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B SBP_bac_11 PF13531.6 CAV26416.1 - 1.9e-42 145.6 0.0 2.1e-42 145.4 0.0 1.0 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_1 PF01547.25 CAV26416.1 - 1.8e-08 34.8 0.0 2.5e-07 31.0 0.0 2.1 1 1 0 1 1 1 1 Bacterial extracellular solute-binding protein BPD_transp_1 PF00528.22 CAV26418.1 - 5.9e-23 81.6 11.8 8e-23 81.1 11.8 1.1 1 0 0 1 1 1 1 Binding-protein-dependent transport system inner membrane component ABC_tran PF00005.27 CAV26420.1 - 4.6e-31 108.2 0.0 1.7e-30 106.3 0.0 1.9 2 0 0 2 2 2 1 ABC transporter TOBE PF03459.17 CAV26420.1 - 4.6e-18 65.3 0.1 4.3e-17 62.2 0.1 2.3 2 0 0 2 2 2 1 TOBE domain AAA_21 PF13304.6 CAV26420.1 - 4.4e-09 36.6 5.1 0.00021 21.2 0.2 2.2 1 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 CAV26420.1 - 6.6e-07 29.0 0.1 0.013 15.0 0.0 2.4 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 CAV26420.1 - 3.9e-06 27.5 0.1 8.5e-06 26.4 0.1 1.5 1 0 0 1 1 1 1 AAA domain RsgA_GTPase PF03193.16 CAV26420.1 - 0.00015 21.7 0.1 0.00029 20.8 0.1 1.4 1 0 0 1 1 1 1 RsgA GTPase AAA_29 PF13555.6 CAV26420.1 - 0.00041 20.0 0.1 0.0012 18.6 0.1 1.7 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_15 PF13175.6 CAV26420.1 - 0.0018 18.1 0.5 0.6 9.8 0.1 2.8 3 0 0 3 3 3 1 AAA ATPase domain MMR_HSR1 PF01926.23 CAV26420.1 - 0.0049 16.9 1.0 0.01 15.9 0.3 1.9 2 0 0 2 2 2 1 50S ribosome-binding GTPase TniB PF05621.11 CAV26420.1 - 0.0087 15.5 0.1 0.37 10.2 0.0 2.2 2 0 0 2 2 2 1 Bacterial TniB protein AAA_22 PF13401.6 CAV26420.1 - 0.017 15.4 0.4 0.091 13.0 0.4 2.3 1 1 0 1 1 1 0 AAA domain Dynamin_N PF00350.23 CAV26420.1 - 0.099 12.7 0.4 0.23 11.5 0.4 1.6 1 0 0 1 1 1 0 Dynamin family AAA_16 PF13191.6 CAV26420.1 - 0.11 12.8 0.0 0.24 11.8 0.0 1.7 1 1 0 1 1 1 0 AAA ATPase domain DUF3069 PF11269.8 CAV26422.1 - 6.3e-52 174.8 2.2 7.6e-52 174.6 2.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3069) KaiA PF07688.12 CAV26422.1 - 0.0015 18.7 0.0 0.0022 18.1 0.0 1.4 1 1 0 1 1 1 1 KaiA C-terminal domain Rop-like PF05082.13 CAV26422.1 - 0.0026 17.5 0.6 0.1 12.5 0.0 2.3 2 0 0 2 2 2 1 Rop-like Perilipin PF03036.16 CAV26422.1 - 0.021 13.9 0.1 0.024 13.7 0.1 1.1 1 0 0 1 1 1 0 Perilipin family DnaJ-X PF14308.6 CAV26422.1 - 0.022 14.2 0.3 0.027 13.9 0.3 1.2 1 0 0 1 1 1 0 X-domain of DnaJ-containing Lipoprotein_6 PF01441.19 CAV26422.1 - 0.03 14.3 0.5 0.087 12.8 0.1 1.8 2 0 0 2 2 2 0 Lipoprotein LPD14 PF18827.1 CAV26422.1 - 0.093 13.0 0.2 0.74 10.1 0.1 2.0 1 1 1 2 2 2 0 Large polyvalent protein-associated domain 14 GGDEF PF00990.21 CAV26424.1 - 6.5e-44 149.5 0.0 1.1e-43 148.8 0.0 1.4 1 0 0 1 1 1 1 Diguanylate cyclase, GGDEF domain Response_reg PF00072.24 CAV26424.1 - 1.9e-25 89.2 0.1 4.4e-25 88.0 0.1 1.7 1 0 0 1 1 1 1 Response regulator receiver domain Omp_AT PF11557.8 CAV26425.1 - 1.1e-108 363.1 9.9 1.3e-108 362.8 9.9 1.0 1 0 0 1 1 1 1 Solitary outer membrane autotransporter beta-barrel domain GGDEF PF00990.21 CAV26427.1 - 4.4e-30 104.5 0.4 8.8e-22 77.6 0.1 2.2 1 1 1 2 2 2 2 Diguanylate cyclase, GGDEF domain OppC_N PF12911.7 CAV26427.1 - 0.3 11.1 5.4 0.4 10.7 0.2 3.1 3 0 0 3 3 3 0 N-terminal TM domain of oligopeptide transport permease C ComFB PF10719.9 CAV26429.1 - 1.3e-11 44.4 0.1 1.7e-11 44.0 0.1 1.2 1 0 0 1 1 1 1 Late competence development protein ComFB HlyU PF10115.9 CAV26431.1 - 1.2e-40 137.5 1.9 1.3e-40 137.4 1.9 1.0 1 0 0 1 1 1 1 Transcriptional activator HlyU AlaDh_PNT_C PF01262.21 CAV26432.1 - 3.4e-73 245.5 3.8 5.2e-73 244.9 3.8 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain AlaDh_PNT_N PF05222.15 CAV26432.1 - 5.1e-48 162.8 0.1 1.1e-47 161.8 0.1 1.6 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, N-terminal domain PNTB_4TM PF12769.7 CAV26432.1 - 1.6e-36 124.6 8.6 6.5e-36 122.7 8.6 2.1 1 0 0 1 1 1 1 4TM region of pyridine nucleotide transhydrogenase, mitoch DUF3392 PF11872.8 CAV26432.1 - 0.0067 16.7 2.2 0.015 15.6 2.2 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF3392) 2-Hacid_dh_C PF02826.19 CAV26432.1 - 0.034 13.5 0.6 5 6.4 0.1 3.1 2 1 1 3 3 3 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain PNTB PF02233.16 CAV26434.1 - 3.3e-200 665.9 22.5 3.7e-200 665.7 22.5 1.0 1 0 0 1 1 1 1 NAD(P) transhydrogenase beta subunit TPP_enzyme_M PF00205.22 CAV26434.1 - 0.0005 19.8 0.5 0.0034 17.1 0.1 2.6 2 1 1 3 3 3 1 Thiamine pyrophosphate enzyme, central domain AA_kinase PF00696.28 CAV26434.1 - 0.023 14.3 0.1 0.043 13.4 0.1 1.4 1 0 0 1 1 1 0 Amino acid kinase family DUF3404 PF11884.8 CAV26437.1 - 9.7e-112 372.5 0.0 1.3e-111 372.1 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3404) HATPase_c PF02518.26 CAV26437.1 - 7.7e-09 36.1 0.0 1.4e-08 35.2 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 CAV26437.1 - 8e-07 29.0 0.2 1.9e-06 27.8 0.2 1.6 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain HATPase_c_5 PF14501.6 CAV26437.1 - 0.059 13.3 0.0 0.12 12.3 0.0 1.4 1 0 0 1 1 1 0 GHKL domain Defensin_propep PF00879.18 CAV26437.1 - 0.16 12.3 0.0 0.41 10.9 0.0 1.6 1 0 0 1 1 1 0 Defensin propeptide Trans_reg_C PF00486.28 CAV26439.1 - 6.3e-24 83.9 0.4 1.7e-23 82.4 0.1 1.8 2 0 0 2 2 2 1 Transcriptional regulatory protein, C terminal Response_reg PF00072.24 CAV26439.1 - 9.8e-17 61.1 0.0 1.4e-16 60.6 0.0 1.3 1 0 0 1 1 1 1 Response regulator receiver domain DUF2861 PF11060.8 CAV26441.1 - 4.6e-96 321.4 5.0 5.2e-96 321.2 5.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2861) TraF_2 PF13729.6 CAV26443.1 - 1.4e-74 251.0 6.5 2.5e-74 250.2 6.5 1.4 1 0 0 1 1 1 1 F plasmid transfer operon, TraF, protein PorP_SprF PF11751.8 CAV26443.1 - 5.8e-06 26.0 4.3 1.8e-05 24.4 4.2 1.8 1 1 0 1 1 1 1 Type IX secretion system membrane protein PorP/SprF OMP_b-brl PF13505.6 CAV26443.1 - 6.3 6.9 20.5 0.15 12.1 7.6 2.5 1 1 0 2 2 2 0 Outer membrane protein beta-barrel domain UPF0181 PF03701.14 CAV26445.1 - 1.1e-25 88.9 6.0 1.2e-25 88.9 6.0 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0181) VWA PF00092.28 CAV26445.1 - 0.03 14.6 0.1 0.032 14.5 0.1 1.0 1 0 0 1 1 1 0 von Willebrand factor type A domain GGDEF PF00990.21 CAV26448.1 - 2.3e-32 112.0 0.2 3.8e-32 111.3 0.2 1.3 1 0 0 1 1 1 1 Diguanylate cyclase, GGDEF domain DUF3653 PF12375.8 CAV26450.1 - 3.5e-06 27.0 0.1 8.7e-06 25.8 0.1 1.6 1 0 0 1 1 1 1 Phage protein HTH_29 PF13551.6 CAV26450.1 - 6.5e-06 26.1 0.9 1.1e-05 25.4 0.7 1.5 1 1 0 1 1 1 1 Winged helix-turn helix HTH_28 PF13518.6 CAV26450.1 - 3.3e-05 23.9 0.7 0.00021 21.3 0.3 2.1 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_23 PF13384.6 CAV26450.1 - 0.00032 20.4 1.1 0.00075 19.2 0.3 1.9 2 0 0 2 2 2 1 Homeodomain-like domain HTH_32 PF13565.6 CAV26450.1 - 0.0061 17.1 0.2 0.011 16.4 0.2 1.5 1 0 0 1 1 1 1 Homeodomain-like domain Cullin PF00888.22 CAV26450.1 - 0.15 10.7 0.0 0.16 10.5 0.0 1.0 1 0 0 1 1 1 0 Cullin family SUI1 PF01253.22 CAV26452.1 - 2.2e-18 66.6 0.4 2.9e-18 66.2 0.4 1.1 1 0 0 1 1 1 1 Translation initiation factor SUI1 Img2 PF05046.14 CAV26452.1 - 0.057 13.7 0.0 0.065 13.5 0.0 1.3 1 1 0 1 1 1 0 Mitochondrial large subunit ribosomal protein (Img2) DUF3319 PF11782.8 CAV26454.1 - 8.9e-41 137.8 0.3 1.3e-40 137.2 0.3 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3319) Phage_integrase PF00589.22 CAV26456.1 - 3.8e-11 43.1 0.1 7.4e-11 42.1 0.1 1.5 1 1 0 1 1 1 1 Phage integrase family Dala_Dala_lig_C PF07478.13 CAV26458.1 - 1.6e-54 184.5 0.1 2.1e-54 184.2 0.1 1.1 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus Dala_Dala_lig_N PF01820.21 CAV26458.1 - 1.4e-21 76.8 0.0 5.1e-21 75.1 0.0 1.9 2 0 0 2 2 2 1 D-ala D-ala ligase N-terminus ATP-grasp PF02222.22 CAV26458.1 - 2.7e-08 33.6 0.2 5.1e-08 32.7 0.2 1.4 1 1 0 1 1 1 1 ATP-grasp domain CPSase_L_D2 PF02786.17 CAV26458.1 - 6e-08 32.4 0.4 4e-07 29.7 0.4 1.9 1 1 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain RimK PF08443.11 CAV26458.1 - 0.072 12.7 0.0 0.13 11.9 0.0 1.3 1 0 0 1 1 1 0 RimK-like ATP-grasp domain ATPgrasp_ST PF14397.6 CAV26458.1 - 0.12 11.6 0.0 0.24 10.6 0.0 1.4 1 0 0 1 1 1 0 Sugar-transfer associated ATP-grasp ATP-grasp_4 PF13535.6 CAV26458.1 - 0.14 11.8 0.9 1.8 8.1 0.9 2.3 1 1 0 1 1 1 0 ATP-grasp domain SfsA PF03749.13 CAV26458.1 - 0.17 11.8 0.3 0.45 10.4 0.0 1.8 2 0 0 2 2 2 0 Sugar fermentation stimulation protein RE domain SPOR PF05036.13 CAV26460.1 - 3.4e-11 43.3 0.0 6.1e-11 42.6 0.0 1.4 1 0 0 1 1 1 1 Sporulation related domain IF4E PF01652.18 CAV26460.1 - 0.085 12.7 0.4 0.26 11.1 0.4 1.9 1 1 0 1 1 1 0 Eukaryotic initiation factor 4E ATP-grasp_5 PF13549.6 CAV26462.1 - 5.9e-69 231.9 0.0 1.1e-68 231.0 0.0 1.5 1 0 0 1 1 1 1 ATP-grasp domain Succ_CoA_lig PF13607.6 CAV26462.1 - 3.7e-50 169.3 0.2 8e-50 168.2 0.2 1.6 1 0 0 1 1 1 1 Succinyl-CoA ligase like flavodoxin domain CoA_binding_2 PF13380.6 CAV26462.1 - 1.6e-23 83.4 0.1 4.7e-23 81.9 0.1 1.9 1 0 0 1 1 1 1 CoA binding domain Acetyltransf_3 PF13302.7 CAV26462.1 - 2.8e-09 37.8 0.0 1e-08 36.0 0.0 2.0 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 CAV26462.1 - 1.2e-06 28.8 0.0 3.5e-06 27.2 0.0 1.8 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family CoA_binding PF02629.19 CAV26462.1 - 2.2e-05 25.1 0.0 5.8e-05 23.7 0.0 1.7 1 0 0 1 1 1 1 CoA binding domain Acetyltransf_10 PF13673.7 CAV26462.1 - 0.034 14.1 0.0 0.081 12.9 0.0 1.6 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain FR47 PF08445.10 CAV26462.1 - 0.039 13.9 0.0 0.29 11.2 0.0 2.4 2 0 0 2 2 2 0 FR47-like protein ATP-grasp PF02222.22 CAV26462.1 - 0.039 13.5 0.0 1.6 8.3 0.0 2.4 2 0 0 2 2 2 0 ATP-grasp domain Acetyltransf_4 PF13420.7 CAV26462.1 - 0.057 13.6 0.0 12 6.0 0.0 3.1 4 0 0 4 4 4 0 Acetyltransferase (GNAT) domain CPSase_L_D2 PF02786.17 CAV26462.1 - 0.066 12.7 0.0 0.13 11.7 0.0 1.5 1 0 0 1 1 1 0 Carbamoyl-phosphate synthase L chain, ATP binding domain HTH_1 PF00126.27 CAV26463.1 - 1.4e-16 60.2 0.0 3e-16 59.1 0.0 1.6 1 0 0 1 1 1 1 Bacterial regulatory helix-turn-helix protein, lysR family LysR_substrate PF03466.20 CAV26463.1 - 3.1e-15 56.1 0.0 6.6e-15 55.0 0.0 1.5 1 1 0 1 1 1 1 LysR substrate binding domain HTH_20 PF12840.7 CAV26463.1 - 0.059 13.4 0.0 0.11 12.5 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain MarR_2 PF12802.7 CAV26463.1 - 0.11 12.4 0.0 0.21 11.5 0.0 1.5 1 0 0 1 1 1 0 MarR family TonB_dep_Rec PF00593.24 CAV26466.1 - 4.6e-54 185.1 35.7 4.6e-54 185.1 35.7 1.4 1 1 0 1 1 1 1 TonB dependent receptor Plug PF07715.15 CAV26466.1 - 4.8e-25 88.2 3.0 4.8e-25 88.2 3.0 2.0 2 0 0 2 2 2 1 TonB-dependent Receptor Plug Domain GDP_Man_Dehyd PF16363.5 CAV26468.1 - 7.1e-61 206.4 0.0 8.2e-61 206.2 0.0 1.0 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 CAV26468.1 - 7.1e-53 179.5 0.0 8.5e-53 179.3 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 CAV26468.1 - 6.2e-18 64.8 0.0 9.9e-18 64.1 0.0 1.3 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Polysacc_synt_2 PF02719.15 CAV26468.1 - 2.3e-17 63.1 0.0 1.4e-16 60.5 0.0 2.1 2 1 0 2 2 2 1 Polysaccharide biosynthesis protein RmlD_sub_bind PF04321.17 CAV26468.1 - 1.3e-10 40.9 0.0 1.9e-10 40.3 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain KR PF08659.10 CAV26468.1 - 4.3e-08 33.3 0.0 8.6e-08 32.3 0.0 1.4 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.6 CAV26468.1 - 2.8e-06 27.3 0.0 4e-06 26.8 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding adh_short PF00106.25 CAV26468.1 - 9.2e-05 22.0 0.0 0.00014 21.4 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase NAD_binding_4 PF07993.12 CAV26468.1 - 0.0014 17.8 0.1 0.0031 16.7 0.0 1.6 2 1 0 2 2 2 1 Male sterility protein NmrA PF05368.13 CAV26468.1 - 0.0023 17.5 0.0 0.021 14.4 0.0 2.1 2 0 0 2 2 2 1 NmrA-like family Methyltransf_28 PF02636.17 CAV26468.1 - 0.008 15.8 0.0 0.013 15.2 0.0 1.3 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase LamB_YcsF PF03746.16 CAV26470.1 - 4.1e-90 301.6 0.0 4.6e-90 301.5 0.0 1.0 1 0 0 1 1 1 1 LamB/YcsF family CT_C_D PF02682.16 CAV26472.1 - 2.1e-52 177.8 0.0 2.6e-52 177.5 0.0 1.1 1 0 0 1 1 1 1 Carboxyltransferase domain, subdomain C and D Erf4 PF10256.9 CAV26472.1 - 0.088 12.9 0.0 0.15 12.2 0.0 1.4 1 0 0 1 1 1 0 Golgin subfamily A member 7/ERF4 family CT_A_B PF02626.15 CAV26473.1 - 5.9e-89 298.2 0.0 6.8e-89 298.0 0.0 1.0 1 0 0 1 1 1 1 Carboxyltransferase domain, subdomain A and B DAO PF01266.24 CAV26475.1 - 1.1e-11 44.9 0.0 2.2e-11 43.9 0.0 1.5 1 1 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 CAV26475.1 - 1e-06 28.3 0.0 1.9e-05 24.1 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 CAV26475.1 - 2.8e-05 24.2 0.1 8.1e-05 22.8 0.1 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.27 CAV26475.1 - 3e-05 24.5 0.0 0.00046 20.7 0.1 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 CAV26475.1 - 0.00014 21.3 0.2 0.046 13.0 0.1 2.2 2 0 0 2 2 2 2 FAD binding domain FAD_oxidored PF12831.7 CAV26475.1 - 0.00032 20.2 0.2 0.026 13.9 0.1 2.2 2 0 0 2 2 2 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 CAV26475.1 - 0.00035 19.8 0.3 0.00057 19.1 0.3 1.3 1 0 0 1 1 1 1 FAD binding domain K_oxygenase PF13434.6 CAV26475.1 - 0.0022 17.2 0.1 0.026 13.7 0.0 2.1 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) HI0933_like PF03486.14 CAV26475.1 - 0.0036 16.1 0.1 0.0069 15.1 0.1 1.4 1 0 0 1 1 1 1 HI0933-like protein Pyr_redox_3 PF13738.6 CAV26475.1 - 0.0042 16.4 0.7 0.02 14.2 0.4 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase AlaDh_PNT_C PF01262.21 CAV26475.1 - 0.0072 15.7 0.0 0.013 14.8 0.0 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain GIDA PF01134.22 CAV26475.1 - 0.0092 15.1 0.1 0.016 14.3 0.1 1.4 1 0 0 1 1 1 1 Glucose inhibited division protein A Thi4 PF01946.17 CAV26475.1 - 0.027 13.7 0.0 0.11 11.8 0.0 1.8 2 0 0 2 2 2 0 Thi4 family EF-hand_4 PF12763.7 CAV26475.1 - 0.062 13.3 0.1 0.23 11.4 0.0 1.9 2 0 0 2 2 2 0 Cytoskeletal-regulatory complex EF hand Lycopene_cycl PF05834.12 CAV26475.1 - 0.069 12.2 0.1 0.13 11.3 0.1 1.4 1 0 0 1 1 1 0 Lycopene cyclase protein Trp_halogenase PF04820.14 CAV26475.1 - 0.11 11.3 0.5 0.29 9.9 0.2 1.7 2 0 0 2 2 2 0 Tryptophan halogenase 3HCDH_N PF02737.18 CAV26475.1 - 0.2 11.5 0.2 0.45 10.4 0.2 1.6 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain FtsX PF02687.21 CAV26477.1 - 1.8e-07 31.5 46.5 4.4e-07 30.3 0.8 5.9 5 1 1 6 6 6 2 FtsX-like permease family ABC2_membrane_3 PF12698.7 CAV26477.1 - 0.0032 16.6 8.2 0.0032 16.6 8.2 3.2 4 1 1 5 5 5 2 ABC-2 family transporter protein GreA_GreB PF01272.19 CAV26477.1 - 0.16 11.9 0.2 0.49 10.3 0.0 1.9 2 0 0 2 2 2 0 Transcription elongation factor, GreA/GreB, C-term ABC_tran PF00005.27 CAV26479.1 - 1.6e-34 119.4 0.0 2.1e-34 119.0 0.0 1.2 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 CAV26479.1 - 5.3e-07 29.7 2.4 0.0003 20.7 0.1 2.1 1 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 CAV26479.1 - 4.1e-06 26.4 0.0 0.0015 18.1 0.0 2.1 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain RsgA_GTPase PF03193.16 CAV26479.1 - 4.5e-05 23.4 0.2 8.2e-05 22.6 0.2 1.4 1 0 0 1 1 1 1 RsgA GTPase AAA_29 PF13555.6 CAV26479.1 - 0.00023 20.9 0.1 0.00043 20.0 0.1 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_15 PF13175.6 CAV26479.1 - 0.003 17.3 0.0 0.5 10.0 0.0 2.1 2 0 0 2 2 2 1 AAA ATPase domain AAA_25 PF13481.6 CAV26479.1 - 0.0036 16.9 0.1 0.077 12.6 0.1 2.2 2 0 0 2 2 2 1 AAA domain MMR_HSR1 PF01926.23 CAV26479.1 - 0.0059 16.7 0.0 0.013 15.6 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_16 PF13191.6 CAV26479.1 - 0.0096 16.3 1.0 0.026 14.9 1.0 1.8 1 1 0 1 1 1 1 AAA ATPase domain AAA_28 PF13521.6 CAV26479.1 - 0.011 16.0 0.5 0.027 14.7 0.5 1.6 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 CAV26479.1 - 0.011 16.2 0.0 0.099 13.2 0.0 2.1 2 0 0 2 2 2 0 AAA domain DUF87 PF01935.17 CAV26479.1 - 0.023 14.8 0.1 0.052 13.6 0.1 1.6 2 0 0 2 2 2 0 Helicase HerA, central domain SbcCD_C PF13558.6 CAV26479.1 - 0.037 14.2 0.1 0.74 10.1 0.1 2.6 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit FtsK_SpoIIIE PF01580.18 CAV26479.1 - 0.037 13.4 0.1 0.07 12.5 0.1 1.4 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_23 PF13476.6 CAV26479.1 - 0.044 14.3 0.0 0.1 13.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 CAV26479.1 - 0.054 13.8 1.2 0.25 11.6 1.2 2.1 1 1 0 1 1 1 0 AAA domain IstB_IS21 PF01695.17 CAV26479.1 - 0.065 13.0 0.1 0.35 10.6 0.0 1.9 2 0 0 2 2 2 0 IstB-like ATP binding protein Dynamin_N PF00350.23 CAV26479.1 - 0.11 12.6 0.0 0.18 11.8 0.0 1.4 1 0 0 1 1 1 0 Dynamin family AAA_30 PF13604.6 CAV26479.1 - 0.12 12.1 0.2 0.28 10.9 0.1 1.6 2 0 0 2 2 2 0 AAA domain AAA_33 PF13671.6 CAV26479.1 - 0.2 11.8 0.6 0.58 10.3 0.6 1.9 1 1 0 1 1 1 0 AAA domain NACHT PF05729.12 CAV26479.1 - 0.25 11.3 1.7 0.85 9.5 0.5 2.1 2 0 0 2 2 2 0 NACHT domain Lipase_GDSL_2 PF13472.6 CAV26481.1 - 1.2e-24 87.7 0.0 1.5e-24 87.3 0.0 1.1 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 CAV26481.1 - 3.8e-13 49.9 0.0 4.5e-13 49.6 0.0 1.1 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase OSK PF17182.4 CAV26481.1 - 0.0055 16.0 0.0 0.0073 15.6 0.0 1.1 1 0 0 1 1 1 1 OSK domain Epimerase_2 PF02350.19 CAV26481.1 - 0.19 10.5 0.0 0.3 9.9 0.0 1.3 1 0 0 1 1 1 0 UDP-N-acetylglucosamine 2-epimerase Enoyl_reductase PF12241.8 CAV26482.1 - 4.8e-97 323.9 0.0 6.4e-97 323.5 0.0 1.1 1 0 0 1 1 1 1 Trans-2-enoyl-CoA reductase catalytic region Eno-Rase_NADH_b PF12242.8 CAV26482.1 - 1.3e-33 114.6 0.1 2.6e-33 113.6 0.1 1.5 1 0 0 1 1 1 1 NAD(P)H binding domain of trans-2-enoyl-CoA reductase Eno-Rase_FAD_bd PF07055.12 CAV26482.1 - 3.8e-23 81.7 0.4 7.5e-23 80.7 0.4 1.5 1 0 0 1 1 1 1 Enoyl reductase FAD binding domain adh_short PF00106.25 CAV26482.1 - 0.0069 15.9 0.5 0.13 11.7 0.5 2.3 1 1 0 1 1 1 1 short chain dehydrogenase DUF2164 PF09932.9 CAV26482.1 - 0.047 13.8 0.5 0.13 12.3 0.0 2.0 3 0 0 3 3 3 0 Uncharacterized conserved protein (DUF2164) EAL PF00563.20 CAV26484.1 - 1.6e-66 224.3 0.7 3.4e-66 223.2 0.1 1.9 2 0 0 2 2 2 1 EAL domain GGDEF PF00990.21 CAV26484.1 - 4.5e-16 59.0 0.3 1.2e-15 57.7 0.3 1.7 1 0 0 1 1 1 1 Diguanylate cyclase, GGDEF domain GAF_2 PF13185.6 CAV26484.1 - 5.8e-09 36.4 0.0 2.3e-08 34.5 0.0 2.0 2 0 0 2 2 2 1 GAF domain PI3K_P85_iSH2 PF16454.5 CAV26484.1 - 0.89 9.1 6.4 1.1 8.8 2.3 2.6 2 0 0 2 2 2 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain ABC_ATPase PF09818.9 CAV26486.1 - 1.3e-180 601.0 0.1 1.6e-180 600.8 0.1 1.0 1 0 0 1 1 1 1 Predicted ATPase of the ABC class AAA_23 PF13476.6 CAV26486.1 - 0.0015 19.0 0.2 0.0047 17.5 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_29 PF13555.6 CAV26486.1 - 0.074 12.8 0.1 0.21 11.3 0.1 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain Transpeptidase PF00905.22 CAV26488.1 - 6.6e-71 239.0 0.0 8.4e-71 238.7 0.0 1.1 1 0 0 1 1 1 1 Penicillin binding protein transpeptidase domain PBP_dimer PF03717.15 CAV26488.1 - 2.1e-48 165.0 0.4 3.7e-48 164.3 0.4 1.4 1 0 0 1 1 1 1 Penicillin-binding Protein dimerisation domain DNAJ_related PF12339.8 CAV26490.1 - 8.1e-43 145.7 0.2 1.1e-42 145.3 0.2 1.2 1 0 0 1 1 1 1 DNA-J related protein DnaJ PF00226.31 CAV26490.1 - 5.1e-12 45.7 0.0 1.9e-10 40.7 0.0 2.3 2 0 0 2 2 2 1 DnaJ domain 2OG-FeII_Oxy PF03171.20 CAV26492.1 - 2.6e-16 60.0 0.0 5.9e-16 58.8 0.0 1.6 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DIOX_N PF14226.6 CAV26492.1 - 4.1e-10 40.5 0.1 6.8e-10 39.7 0.1 1.3 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal DUF3929 PF13066.6 CAV26492.1 - 0.15 12.2 0.0 0.31 11.1 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3929) DUF2238 PF09997.9 CAV26494.1 - 1.4e-52 177.2 2.7 1.4e-52 177.2 2.7 1.4 2 0 0 2 2 2 1 Predicted membrane protein (DUF2238) CPP1-like PF11833.8 CAV26494.1 - 0.2 11.3 2.9 0.15 11.7 1.3 1.5 2 0 0 2 2 2 0 Protein CHAPERONE-LIKE PROTEIN OF POR1-like EamA PF00892.20 CAV26496.1 - 1.9e-23 83.1 41.4 1.1e-14 54.7 20.9 2.1 2 0 0 2 2 2 2 EamA-like transporter family DUF4713 PF15831.5 CAV26496.1 - 1.5 9.3 5.3 11 6.6 0.2 3.4 2 1 1 3 3 3 0 Domain of unknown function (DUF4713) DUF3624 PF12292.8 CAV26496.1 - 2.6 8.5 16.6 0.67 10.4 0.5 3.8 3 1 0 3 3 3 0 Protein of unknown function (DUF3624) HNF-1B_C PF04812.13 CAV26496.1 - 2.8 7.7 6.9 4.1 7.2 6.7 1.4 1 1 0 1 1 1 0 Hepatocyte nuclear factor 1 (HNF-1), beta isoform C terminus SgrR_N PF12793.7 CAV26497.1 - 3.1e-39 133.7 0.1 4.8e-39 133.1 0.1 1.3 1 0 0 1 1 1 1 Sugar transport-related sRNA regulator N-term SBP_bac_5 PF00496.22 CAV26497.1 - 5.8e-20 71.6 0.0 9.8e-18 64.3 0.0 2.3 2 0 0 2 2 2 2 Bacterial extracellular solute-binding proteins, family 5 Middle DUF3389 PF11869.8 CAV26499.1 - 1.9e-36 124.1 0.6 2.1e-36 123.9 0.6 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3389) 4HBT PF03061.22 CAV26501.1 - 9.5e-15 54.7 0.2 1.3e-14 54.3 0.2 1.2 1 0 0 1 1 1 1 Thioesterase superfamily DUF4442 PF14539.6 CAV26501.1 - 0.00046 20.3 0.2 0.00062 19.9 0.2 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4442) Nudix_N_2 PF14803.6 CAV26501.1 - 0.064 13.2 0.5 0.16 11.9 0.0 1.9 2 0 0 2 2 2 0 Nudix N-terminal Peptidase_M48 PF01435.18 CAV26503.1 - 5.7e-46 156.8 0.0 7.4e-46 156.4 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M48 Peptidase_M50 PF02163.22 CAV26505.1 - 5.6e-12 45.5 13.3 6.3e-06 25.6 2.5 3.2 1 1 1 2 2 2 2 Peptidase family M50 Toluene_X PF03349.16 CAV26506.1 - 4.1e-133 444.1 9.0 4.6e-133 444.0 9.0 1.0 1 0 0 1 1 1 1 Outer membrane protein transport protein (OMPP1/FadL/TodX) DUF2490 PF10677.9 CAV26506.1 - 6e-07 29.6 2.2 0.026 14.5 1.0 4.0 1 1 1 2 2 2 2 Protein of unknown function (DUF2490) OMP_b-brl PF13505.6 CAV26506.1 - 8e-06 26.1 14.6 0.0028 17.8 6.7 3.0 1 1 1 2 2 2 2 Outer membrane protein beta-barrel domain Porin_4 PF13609.6 CAV26506.1 - 0.00032 20.6 14.9 0.0074 16.1 14.9 2.2 1 1 0 1 1 1 1 Gram-negative porin BBP2 PF07642.11 CAV26506.1 - 0.029 13.5 9.9 0.18 10.9 3.5 2.7 1 1 1 2 2 2 0 Putative beta-barrel porin-2, OmpL-like. bbp2 YadA_anchor PF03895.15 CAV26506.1 - 0.041 14.0 0.3 4.8 7.4 0.0 3.7 3 1 1 4 4 4 0 YadA-like membrane anchor domain Lipase_bact_N PF12262.8 CAV26508.1 - 1e-110 368.7 10.4 2.1e-110 367.7 10.4 1.6 1 0 0 1 1 1 1 Bacterial virulence factor lipase N-terminal Hydrolase_4 PF12146.8 CAV26508.1 - 0.0014 18.0 0.3 0.23 10.7 0.0 2.4 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 CAV26508.1 - 0.011 15.4 0.1 3 7.4 0.0 2.5 2 0 0 2 2 2 0 alpha/beta hydrolase fold DUF1100 PF06500.11 CAV26508.1 - 0.014 14.2 0.0 0.025 13.4 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF1100) Abhydrolase_6 PF12697.7 CAV26508.1 - 0.021 15.4 7.1 0.016 15.8 4.8 1.9 2 1 0 2 2 2 0 Alpha/beta hydrolase family DUF676 PF05057.14 CAV26508.1 - 0.042 13.4 0.1 0.24 10.9 0.1 2.1 2 0 0 2 2 2 0 Putative serine esterase (DUF676) DUF4525 PF15027.6 CAV26508.1 - 0.07 12.9 0.0 0.14 11.9 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4525) PhnA PF03831.14 CAV26509.1 - 4.3e-21 74.6 1.8 6.2e-21 74.1 1.8 1.2 1 0 0 1 1 1 1 PhnA domain PhnA_Zn_Ribbon PF08274.12 CAV26509.1 - 9.3e-10 38.3 1.7 1.7e-09 37.5 1.7 1.4 1 0 0 1 1 1 1 PhnA Zinc-Ribbon FpoO PF10621.9 CAV26509.1 - 0.0015 18.8 0.3 0.0027 18.0 0.3 1.3 1 0 0 1 1 1 1 F420H2 dehydrogenase subunit FpoO zf-HYPF PF07503.12 CAV26509.1 - 0.17 11.7 1.6 0.21 11.4 0.1 1.8 2 0 0 2 2 2 0 HypF finger DEAD PF00270.29 CAV26511.1 - 4.2e-49 166.7 0.1 1.1e-48 165.3 0.0 1.7 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CAV26511.1 - 5.3e-31 107.2 0.1 1.1e-29 102.9 0.0 2.7 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 CAV26511.1 - 1.6e-05 24.9 0.0 9.5e-05 22.5 0.0 2.0 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 CAV26511.1 - 0.0013 18.0 0.0 0.0021 17.3 0.0 1.2 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase CMS1 PF14617.6 CAV26511.1 - 0.0043 16.4 0.1 0.0082 15.5 0.1 1.4 1 0 0 1 1 1 1 U3-containing 90S pre-ribosomal complex subunit AAA_22 PF13401.6 CAV26511.1 - 0.02 15.2 0.1 0.31 11.3 0.1 2.6 2 1 0 2 2 2 0 AAA domain DUF1223 PF06764.11 CAV26513.1 - 1e-46 159.6 0.0 1.5e-46 159.0 0.0 1.3 1 1 0 1 1 1 1 Protein of unknown function (DUF1223) TerC PF03741.16 CAV26517.1 - 2.3e-53 180.5 10.6 2.3e-53 180.5 10.6 2.0 2 0 0 2 2 2 1 Integral membrane protein TerC family DUF475 PF04332.15 CAV26517.1 - 0.0037 17.1 10.6 0.0037 17.1 10.6 2.0 1 1 1 2 2 2 1 Protein of unknown function (DUF475) DUF1418 PF07214.12 CAV26517.1 - 0.011 15.6 7.0 0.084 12.7 0.0 2.9 2 1 0 2 2 2 0 Protein of unknown function (DUF1418) MitoNEET_N PF10660.9 CAV26519.1 - 0.64 10.1 5.7 1 9.4 0.2 2.1 2 0 0 2 2 2 0 Iron-containing outer mitochondrial membrane protein N-terminus 5_nucleotid_C PF02872.18 CAV26520.1 - 1.5e-21 77.3 0.0 3.3e-21 76.1 0.0 1.6 1 0 0 1 1 1 1 5'-nucleotidase, C-terminal domain Metallophos PF00149.28 CAV26520.1 - 0.04 14.4 0.0 0.12 12.9 0.0 1.8 1 1 0 1 1 1 0 Calcineurin-like phosphoesterase NAD_binding_10 PF13460.6 CAV26520.1 - 0.15 11.9 0.0 0.36 10.7 0.0 1.5 1 0 0 1 1 1 0 NAD(P)H-binding Metallophos PF00149.28 CAV26522.1 - 0.031 14.8 0.0 0.036 14.6 0.0 1.1 1 0 0 1 1 1 0 Calcineurin-like phosphoesterase DUF2813 PF11398.8 CAV26524.1 - 5.2e-140 466.9 0.6 1.6e-74 251.4 0.1 2.1 2 0 0 2 2 2 2 Protein of unknown function (DUF2813) AAA_15 PF13175.6 CAV26524.1 - 3.4e-12 46.8 0.0 5.1e-11 42.9 0.0 2.1 2 0 0 2 2 2 1 AAA ATPase domain AAA_29 PF13555.6 CAV26524.1 - 1.3e-05 24.8 0.0 3.1e-05 23.6 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain SMC_N PF02463.19 CAV26524.1 - 1.7e-05 24.4 0.0 3.3e-05 23.4 0.0 1.5 1 0 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 CAV26524.1 - 6.6e-05 22.9 0.0 0.18 11.6 0.0 2.4 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 CAV26524.1 - 0.00013 22.6 0.0 0.00025 21.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_27 PF13514.6 CAV26524.1 - 0.026 14.1 0.0 0.052 13.1 0.0 1.6 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 CAV26524.1 - 0.092 13.3 0.0 0.24 11.9 0.0 1.7 1 0 0 1 1 1 0 ABC transporter DUF1097 PF06496.11 CAV26526.1 - 1.3e-35 122.6 28.2 1.5e-35 122.4 28.2 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1097) Phage_HK97_TLTM PF06120.11 CAV26526.1 - 0.083 12.1 0.0 0.15 11.2 0.0 1.4 1 0 0 1 1 1 0 Tail length tape measure protein LysR_substrate PF03466.20 CAV26527.1 - 7.5e-43 146.3 0.2 1e-42 145.9 0.2 1.1 1 0 0 1 1 1 1 LysR substrate binding domain HTH_1 PF00126.27 CAV26527.1 - 3.2e-20 71.8 0.4 5.7e-20 71.0 0.4 1.4 1 0 0 1 1 1 1 Bacterial regulatory helix-turn-helix protein, lysR family PBP_like PF12727.7 CAV26527.1 - 0.00094 18.4 0.0 0.0015 17.7 0.0 1.4 1 0 0 1 1 1 1 PBP superfamily domain MarR_2 PF12802.7 CAV26527.1 - 0.013 15.4 0.7 0.079 12.9 0.1 2.3 2 0 0 2 2 2 0 MarR family HTH_5 PF01022.20 CAV26527.1 - 0.021 14.7 0.1 0.045 13.6 0.1 1.5 1 0 0 1 1 1 0 Bacterial regulatory protein, arsR family GntR PF00392.21 CAV26527.1 - 0.098 12.3 0.4 0.4 10.4 0.1 2.1 2 0 0 2 2 2 0 Bacterial regulatory proteins, gntR family HTH_20 PF12840.7 CAV26527.1 - 0.11 12.5 0.1 0.27 11.3 0.1 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain Form_Nir_trans PF01226.17 CAV26529.1 - 9.4e-71 237.9 29.6 1.2e-70 237.5 29.6 1.1 1 0 0 1 1 1 1 Formate/nitrite transporter CBS PF00571.28 CAV26529.1 - 1.1e-11 45.0 5.7 2.1e-06 28.1 0.5 3.3 2 1 0 2 2 2 2 CBS domain YceI PF04264.13 CAV26531.1 - 9.7e-34 117.0 0.9 1.3e-33 116.6 0.9 1.1 1 0 0 1 1 1 1 YceI-like domain DUF945 PF06097.11 CAV26531.1 - 0.45 9.6 4.9 0.55 9.3 3.6 1.6 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF945) Ni_hydr_CYTB PF01292.20 CAV26533.1 - 3.2e-09 36.7 0.4 3.2e-09 36.6 0.4 1.1 1 0 0 1 1 1 1 Prokaryotic cytochrome b561 DUF4405 PF14358.6 CAV26533.1 - 0.015 15.8 0.3 0.018 15.6 0.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4405) DUF2427 PF10348.9 CAV26533.1 - 0.027 14.3 1.1 0.033 14.0 1.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF2427) Mtr2 PF10429.9 CAV26533.1 - 0.032 14.2 0.0 0.035 14.1 0.0 1.1 1 0 0 1 1 1 0 Nuclear pore RNA shuttling protein Mtr2 Ni_hydr_CYTB PF01292.20 CAV26534.1 - 3.2e-13 49.7 0.9 3.4e-13 49.6 0.9 1.0 1 0 0 1 1 1 1 Prokaryotic cytochrome b561 Intg_mem_TP0381 PF09529.10 CAV26534.1 - 0.011 15.2 0.2 0.014 15.0 0.2 1.1 1 0 0 1 1 1 0 Integral membrane protein (intg_mem_TP0381) DUF4079 PF13301.6 CAV26534.1 - 0.022 14.9 0.1 0.031 14.4 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4079) DUF202 PF02656.15 CAV26534.1 - 0.04 14.4 2.4 0.055 13.9 2.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF202) DUF2164 PF09932.9 CAV26536.1 - 7.9e-29 99.5 2.3 8.9e-29 99.4 2.3 1.0 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2164) Ribonucleas_3_3 PF14622.6 CAV26536.1 - 0.021 15.0 0.0 0.028 14.6 0.0 1.3 1 1 0 1 1 1 0 Ribonuclease-III-like YolD PF08863.10 CAV26536.1 - 0.064 13.3 2.2 0.21 11.7 0.2 2.0 2 0 0 2 2 2 0 YolD-like protein EAL PF00563.20 CAV26542.1 - 2.3e-45 155.0 0.9 2.7e-45 154.7 0.9 1.0 1 0 0 1 1 1 1 EAL domain Phage_int_SAM_4 PF13495.6 CAV26542.1 - 0.013 15.9 0.0 0.025 15.0 0.0 1.4 1 0 0 1 1 1 0 Phage integrase, N-terminal SAM-like domain ADH_zinc_N PF00107.26 CAV26542.1 - 0.046 13.7 0.0 15 5.6 0.0 2.8 3 0 0 3 3 3 0 Zinc-binding dehydrogenase ATP-synt_D PF01813.17 CAV26542.1 - 0.055 13.3 0.2 0.077 12.8 0.2 1.3 1 0 0 1 1 1 0 ATP synthase subunit D DUF3352 PF11832.8 CAV26542.1 - 0.092 11.4 0.0 0.13 10.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3352) SBP_bac_5 PF00496.22 CAV26542.1 - 0.22 10.4 0.0 0.29 10.0 0.0 1.2 1 0 0 1 1 1 0 Bacterial extracellular solute-binding proteins, family 5 Middle ACR_tran PF00873.19 CAV26543.1 - 1.7e-177 592.1 7.7 2e-177 591.9 7.7 1.0 1 0 0 1 1 1 1 AcrB/AcrD/AcrF family DUF3817 PF12823.7 CAV26543.1 - 0.031 15.1 0.5 0.031 15.1 0.5 3.9 4 1 0 4 4 4 0 Domain of unknown function (DUF3817) HlyD_D23 PF16576.5 CAV26545.1 - 1.2e-13 50.8 0.0 1.8e-13 50.2 0.0 1.3 1 0 0 1 1 1 1 Barrel-sandwich domain of CusB or HlyD membrane-fusion Biotin_lipoyl_2 PF13533.6 CAV26545.1 - 3.3e-10 39.6 0.5 1.9e-09 37.2 0.3 2.4 2 0 0 2 2 2 1 Biotin-lipoyl like HlyD_3 PF13437.6 CAV26545.1 - 1.9e-07 31.7 0.0 0.00015 22.4 0.0 3.0 2 1 1 3 3 3 2 HlyD family secretion protein RnfC_N PF13375.6 CAV26545.1 - 5.3e-05 23.1 0.0 0.022 14.7 0.0 2.4 2 0 0 2 2 2 2 RnfC Barrel sandwich hybrid domain Biotin_lipoyl PF00364.22 CAV26545.1 - 0.00017 21.3 0.1 0.0044 16.8 0.0 2.8 3 0 0 3 3 3 1 Biotin-requiring enzyme PTS_EIIA_1 PF00358.20 CAV26545.1 - 0.00092 19.0 0.2 0.078 12.7 0.1 3.0 3 1 0 3 3 3 1 phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1 Peptidase_M23 PF01551.22 CAV26545.1 - 0.0078 16.4 0.0 0.21 11.8 0.0 2.4 2 0 0 2 2 2 1 Peptidase family M23 Biotin_lipoyl_2 PF13533.6 CAV26547.1 - 1.7e-09 37.4 3.6 4.1e-09 36.1 0.8 2.9 3 0 0 3 3 3 1 Biotin-lipoyl like HlyD_3 PF13437.6 CAV26547.1 - 5.1e-09 36.8 0.4 8.9e-08 32.8 0.0 2.6 2 0 0 2 2 2 1 HlyD family secretion protein HlyD_D23 PF16576.5 CAV26547.1 - 1.2e-07 31.1 0.3 1.6e-07 30.8 0.3 1.3 1 0 0 1 1 1 1 Barrel-sandwich domain of CusB or HlyD membrane-fusion PTS_EIIA_1 PF00358.20 CAV26547.1 - 0.0061 16.3 0.1 0.45 10.3 0.0 2.4 2 0 0 2 2 2 1 phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1 Biotin_lipoyl PF00364.22 CAV26547.1 - 0.019 14.8 0.2 1 9.2 0.1 2.7 2 0 0 2 2 2 0 Biotin-requiring enzyme OEP PF02321.18 CAV26547.1 - 0.07 12.9 6.1 0.067 13.0 4.9 1.5 2 0 0 2 2 2 0 Outer membrane efflux protein PYNP_C PF07831.13 CAV26547.1 - 0.12 12.0 0.2 1.5 8.5 0.0 2.5 2 1 1 3 3 3 0 Pyrimidine nucleoside phosphorylase C-terminal domain TetR_N PF00440.23 CAV26549.1 - 4.3e-12 45.6 0.0 8.5e-12 44.7 0.0 1.5 1 0 0 1 1 1 1 Bacterial regulatory proteins, tetR family DEAD PF00270.29 CAV26551.1 - 4.9e-54 182.7 0.2 9.6e-54 181.8 0.2 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CAV26551.1 - 2.7e-30 105.0 0.1 1.2e-28 99.7 0.0 2.9 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 CAV26551.1 - 3.1e-10 40.3 0.0 7.3e-10 39.1 0.0 1.6 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Helicase_RecD PF05127.14 CAV26551.1 - 0.0011 18.8 0.0 0.0035 17.2 0.0 1.8 1 1 1 2 2 2 1 Helicase AAA_22 PF13401.6 CAV26551.1 - 0.003 17.9 0.0 0.0092 16.3 0.0 1.9 1 1 0 1 1 1 1 AAA domain ACP_PD PF04336.12 CAV26552.1 - 7e-29 100.3 5.1 2.1e-28 98.8 4.8 1.8 2 0 0 2 2 2 1 Acyl carrier protein phosphodiesterase Trp_Tyr_perm PF03222.13 CAV26556.1 - 6e-109 364.7 34.2 7.2e-109 364.4 34.2 1.0 1 0 0 1 1 1 1 Tryptophan/tyrosine permease family AA_permease_2 PF13520.6 CAV26556.1 - 2e-08 33.5 28.7 2e-08 33.5 28.7 2.0 2 0 0 2 2 2 1 Amino acid permease Aa_trans PF01490.18 CAV26556.1 - 2.7e-08 32.9 18.5 2.7e-08 32.9 18.5 2.2 2 0 0 2 2 2 1 Transmembrane amino acid transporter protein MCPsignal PF00015.21 CAV26558.1 - 2.1e-37 128.5 26.2 2.1e-37 128.5 26.2 3.4 2 1 1 3 3 3 2 Methyl-accepting chemotaxis protein (MCP) signalling domain HAMP PF00672.25 CAV26558.1 - 1.1e-07 32.1 0.2 4.3e-06 27.0 0.0 3.6 4 0 0 4 4 3 1 HAMP domain DUF4200 PF13863.6 CAV26558.1 - 0.0082 16.5 2.6 0.0082 16.5 2.6 2.9 2 1 0 2 2 2 1 Domain of unknown function (DUF4200) ECM11 PF15463.6 CAV26558.1 - 0.028 15.0 5.1 0.059 14.0 0.1 3.0 2 1 0 2 2 2 0 Extracellular mutant protein 11 BLOC1_2 PF10046.9 CAV26558.1 - 0.033 14.5 28.1 1.5 9.2 4.2 4.5 3 1 1 4 4 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 S6PP_C PF08472.10 CAV26558.1 - 0.087 12.7 0.1 0.19 11.6 0.1 1.5 1 0 0 1 1 1 0 Sucrose-6-phosphate phosphohydrolase C-terminal DUF1664 PF07889.12 CAV26558.1 - 0.52 10.4 31.7 1.3 9.0 4.7 4.6 2 2 2 4 4 4 0 Protein of unknown function (DUF1664) ERM PF00769.19 CAV26558.1 - 0.79 9.5 22.9 2.7 7.8 13.2 2.4 1 1 1 2 2 2 0 Ezrin/radixin/moesin family LMBR1 PF04791.16 CAV26558.1 - 1.1 8.1 13.6 40 2.9 13.6 2.4 1 1 0 1 1 1 0 LMBR1-like membrane protein DUF2935 PF11155.8 CAV26558.1 - 1.3 9.4 9.5 18 5.7 2.3 3.9 2 2 1 3 3 3 0 Domain of unknown function (DUF2935) ZirS_C PF16583.5 CAV26558.1 - 1.3 8.6 6.9 2.1 7.9 0.2 2.9 2 1 0 2 2 2 0 Zinc-regulated secreted antivirulence protein C-terminal domain ISG65-75 PF11727.8 CAV26558.1 - 2.2 7.5 21.2 2.3 7.4 4.0 2.7 1 1 2 3 3 3 0 Invariant surface glycoprotein HAD_2 PF13419.6 CAV26559.1 - 5.1e-27 95.1 0.0 6.2e-27 94.8 0.0 1.1 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 CAV26559.1 - 3.5e-14 53.6 0.0 5.6e-13 49.7 0.0 2.0 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 CAV26559.1 - 1.1e-05 26.0 0.0 1.5e-05 25.5 0.0 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_6 PF13344.6 CAV26559.1 - 4.9e-05 23.4 0.0 0.14 12.3 0.0 2.2 2 0 0 2 2 2 2 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 CAV26559.1 - 0.017 15.2 0.0 0.031 14.3 0.0 1.4 1 0 0 1 1 1 0 HAD-hyrolase-like Hydrolase_3 PF08282.12 CAV26559.1 - 0.14 11.8 0.0 13 5.4 0.0 2.2 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase Bunya_NS-S_2 PF03231.13 CAV26559.1 - 0.17 10.6 0.0 0.22 10.3 0.0 1.1 1 0 0 1 1 1 0 Bunyavirus non-structural protein NS-S HD PF01966.22 CAV26561.1 - 2e-16 60.3 0.1 3.4e-16 59.6 0.1 1.4 1 0 0 1 1 1 1 HD domain HD_5 PF13487.6 CAV26561.1 - 6.1e-14 52.0 0.0 4.7e-13 49.2 0.0 2.4 2 0 0 2 2 2 1 HD domain LapA_dom PF06305.11 CAV26561.1 - 0.32 10.9 4.2 0.6 10.0 4.2 1.4 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain Csm1_B PF18211.1 CAV26563.1 - 0.083 12.7 0.1 8.3 6.3 0.0 2.4 2 0 0 2 2 2 0 Csm1 subunit domain B CreA PF05981.12 CAV26565.1 - 1.2e-44 151.4 0.6 1.5e-44 151.2 0.6 1.1 1 0 0 1 1 1 1 CreA protein LPAM_1 PF08139.12 CAV26565.1 - 0.00019 21.8 3.3 0.00046 20.5 3.3 1.7 1 0 0 1 1 1 1 Prokaryotic membrane lipoprotein lipid attachment site Pox_RNA_pol PF03293.14 CAV26565.1 - 0.019 14.7 0.1 0.031 14.0 0.1 1.3 1 1 0 1 1 1 0 Poxvirus DNA-directed RNA polymerase, 18 kD subunit PfkB PF00294.24 CAV26566.1 - 3.7e-16 59.3 0.0 8.9e-12 44.9 0.0 2.3 2 0 0 2 2 2 2 pfkB family carbohydrate kinase FTHFS PF01268.19 CAV26568.1 - 7.4e-238 790.3 0.1 8.4e-238 790.1 0.1 1.0 1 0 0 1 1 1 1 Formate--tetrahydrofolate ligase GGDEF PF00990.21 CAV26570.1 - 3.6e-33 114.6 0.0 1.5e-32 112.6 0.0 2.1 2 0 0 2 2 2 1 Diguanylate cyclase, GGDEF domain dCache_1 PF02743.18 CAV26570.1 - 4.9e-13 49.4 0.8 4.9e-13 49.4 0.8 1.8 2 0 0 2 2 2 1 Cache domain PAS_9 PF13426.7 CAV26570.1 - 1.4e-12 47.8 0.3 4.9e-12 46.0 0.3 1.9 1 0 0 1 1 1 1 PAS domain PAS PF00989.25 CAV26570.1 - 3e-08 33.7 0.1 7.8e-08 32.3 0.1 1.7 1 0 0 1 1 1 1 PAS fold PAS_3 PF08447.12 CAV26570.1 - 7.3e-06 26.2 0.2 6.7e-05 23.1 0.1 2.5 2 0 0 2 2 2 1 PAS fold PAS_8 PF13188.7 CAV26570.1 - 7.1e-05 22.7 0.0 0.00029 20.8 0.0 2.0 2 0 0 2 2 2 1 PAS domain PAS_4 PF08448.10 CAV26570.1 - 0.0031 17.8 0.0 0.0084 16.4 0.0 1.8 1 0 0 1 1 1 1 PAS fold GGDEF_2 PF17853.1 CAV26570.1 - 0.036 14.3 0.0 0.12 12.7 0.0 1.8 1 0 0 1 1 1 0 GGDEF-like domain HAD_2 PF13419.6 CAV26572.1 - 1.5e-26 93.6 0.0 2e-26 93.2 0.0 1.2 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 CAV26572.1 - 4e-12 46.9 0.1 1.8e-09 38.2 0.1 2.1 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 CAV26572.1 - 6.2e-07 29.4 0.0 8.1e-06 25.8 0.0 2.1 2 0 0 2 2 2 1 HAD-hyrolase-like RF-1 PF00472.20 CAV26573.1 - 1.9e-25 89.1 4.8 2.3e-25 88.8 4.8 1.0 1 0 0 1 1 1 1 RF-1 domain DIPSY PF11763.8 CAV26573.1 - 0.15 12.3 0.0 0.19 11.9 0.0 1.3 1 0 0 1 1 1 0 Cell-wall adhesin ligand-binding C-terminal HTH_3 PF01381.22 CAV26575.1 - 1.2e-09 38.1 0.3 1.9e-09 37.4 0.3 1.3 1 0 0 1 1 1 1 Helix-turn-helix HTH_31 PF13560.6 CAV26575.1 - 2.9e-08 33.9 0.5 6.8e-08 32.7 0.2 1.7 1 1 0 1 1 1 1 Helix-turn-helix domain HTH_19 PF12844.7 CAV26575.1 - 7.7e-05 22.6 0.0 0.00014 21.8 0.0 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain NARP1 PF12569.8 CAV26577.1 - 0.0073 15.3 0.2 0.016 14.2 0.2 1.6 1 1 1 2 2 2 1 NMDA receptor-regulated protein 1 Hrs_helical PF12210.8 CAV26577.1 - 0.013 16.1 1.4 2.7 8.6 0.2 2.3 1 1 1 2 2 2 0 Hepatocyte growth factor-regulated tyrosine kinase substrate Trypsin PF00089.26 CAV26579.1 - 3.9e-35 121.7 0.2 5.2e-35 121.3 0.2 1.2 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.6 CAV26579.1 - 5.3e-09 37.1 1.5 7.6e-09 36.6 0.1 1.8 2 0 0 2 2 2 1 Trypsin-like peptidase domain GCV_T PF01571.21 CAV26581.1 - 2.7e-87 292.4 0.0 4.6e-87 291.6 0.0 1.4 1 0 0 1 1 1 1 Aminomethyltransferase folate-binding domain GCV_T_C PF08669.11 CAV26581.1 - 6.5e-18 64.4 0.2 1.4e-17 63.3 0.2 1.5 1 0 0 1 1 1 1 Glycine cleavage T-protein C-terminal barrel domain SoxG PF04268.12 CAV26581.1 - 0.0065 16.6 0.0 3.1 7.9 0.0 2.6 1 1 0 2 2 2 2 Sarcosine oxidase, gamma subunit family HTH_3 PF01381.22 CAV26582.1 - 1.8e-12 47.1 0.2 2.8e-12 46.5 0.2 1.3 1 0 0 1 1 1 1 Helix-turn-helix Cupin_2 PF07883.11 CAV26582.1 - 1.4e-09 37.5 0.0 2.4e-09 36.8 0.0 1.3 1 0 0 1 1 1 1 Cupin domain HTH_31 PF13560.6 CAV26582.1 - 1.5e-09 38.0 0.0 2.6e-09 37.3 0.0 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_19 PF12844.7 CAV26582.1 - 2.1e-09 37.3 0.1 3.7e-09 36.5 0.1 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_25 PF13413.6 CAV26582.1 - 0.00011 22.0 0.4 0.00021 21.1 0.1 1.6 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_26 PF13443.6 CAV26582.1 - 0.00049 20.5 0.0 0.00079 19.8 0.0 1.4 1 0 0 1 1 1 1 Cro/C1-type HTH DNA-binding domain Glyco_transf_49 PF13896.6 CAV26582.1 - 0.0045 16.4 0.0 0.006 16.0 0.0 1.1 1 0 0 1 1 1 1 Glycosyl-transferase for dystroglycan Cupin_3 PF05899.12 CAV26582.1 - 0.0062 16.2 0.0 0.0099 15.6 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF861) HTH_37 PF13744.6 CAV26582.1 - 0.0095 15.9 0.6 0.015 15.3 0.0 1.5 2 0 0 2 2 2 1 Helix-turn-helix domain SHMT PF00464.19 CAV26584.1 - 2.8e-174 579.4 0.0 3.3e-174 579.2 0.0 1.0 1 0 0 1 1 1 1 Serine hydroxymethyltransferase DegT_DnrJ_EryC1 PF01041.17 CAV26584.1 - 5.2e-07 29.3 0.3 8.1e-07 28.7 0.3 1.2 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_1_2 PF00155.21 CAV26584.1 - 1.7e-06 27.5 0.0 2.6e-06 26.9 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.20 CAV26584.1 - 0.087 11.3 0.0 0.13 10.8 0.0 1.3 1 0 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme GCV_H PF01597.19 CAV26586.1 - 2.5e-49 166.2 1.0 2.8e-49 166.1 1.0 1.0 1 0 0 1 1 1 1 Glycine cleavage H-protein Biotin_lipoyl PF00364.22 CAV26586.1 - 0.0029 17.4 0.1 0.0076 16.1 0.0 1.7 2 0 0 2 2 2 1 Biotin-requiring enzyme RnfC_N PF13375.6 CAV26586.1 - 0.029 14.3 0.0 0.038 13.9 0.0 1.3 1 0 0 1 1 1 0 RnfC Barrel sandwich hybrid domain GDC-P PF02347.16 CAV26588.1 - 2.2e-190 633.1 3.3 6.5e-179 595.3 3.3 2.3 2 0 0 2 2 2 2 Glycine cleavage system P-protein Beta_elim_lyase PF01212.21 CAV26588.1 - 1.9e-07 30.7 1.5 6.2e-07 29.0 0.1 2.2 2 1 0 2 2 2 1 Beta-eliminating lyase Aminotran_5 PF00266.19 CAV26588.1 - 5.7e-06 25.5 1.1 0.00061 18.9 0.1 2.4 2 0 0 2 2 2 2 Aminotransferase class-V RNase_H2-Ydr279 PF09468.10 CAV26588.1 - 0.082 13.1 0.0 0.18 12.0 0.0 1.5 1 0 0 1 1 1 0 Ydr279p protein family (RNase H2 complex component) wHTH domain Aminotran_1_2 PF00155.21 CAV26588.1 - 0.085 12.0 0.1 0.3 10.2 0.0 1.8 2 0 0 2 2 2 0 Aminotransferase class I and II Peptidase_M23 PF01551.22 CAV26589.1 - 2.2e-18 66.2 0.0 3.1e-18 65.8 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M23 Corona_6B_7B PF03262.13 CAV26589.1 - 0.054 12.9 0.0 0.082 12.3 0.0 1.3 1 0 0 1 1 1 0 Coronavirus 6B/7B protein rve PF00665.26 CAV26593.1 - 2.2e-15 56.9 0.0 2.7e-15 56.6 0.0 1.1 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 CAV26593.1 - 1.4e-05 24.8 0.0 2.2e-05 24.2 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain HTH_21 PF13276.6 CAV26595.1 - 2e-20 72.7 3.6 3.5e-20 71.9 3.6 1.4 1 0 0 1 1 1 1 HTH-like domain rve PF00665.26 CAV26595.1 - 8.3e-08 32.4 0.5 1.9e-07 31.3 0.1 1.8 2 1 0 2 2 2 1 Integrase core domain HTH_Tnp_Tc3_2 PF01498.18 CAV26595.1 - 0.0032 17.7 0.9 0.0055 16.9 0.9 1.4 1 0 0 1 1 1 1 Transposase HTH_17 PF12728.7 CAV26595.1 - 0.01 16.0 2.0 3.8 7.8 0.0 3.3 3 0 0 3 3 3 0 Helix-turn-helix domain Lysyl_oxidase PF01186.17 CAV26595.1 - 0.1 12.2 0.0 0.15 11.7 0.0 1.3 1 0 0 1 1 1 0 Lysyl oxidase HTH_Tnp_1 PF01527.20 CAV26597.1 - 1e-14 54.6 1.2 1e-14 54.6 1.2 1.5 1 1 0 1 1 1 1 Transposase HTH_28 PF13518.6 CAV26597.1 - 0.00081 19.5 0.0 0.0015 18.6 0.0 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_23 PF13384.6 CAV26597.1 - 0.0019 17.9 0.0 0.0037 17.0 0.0 1.5 1 0 0 1 1 1 1 Homeodomain-like domain TSC22 PF01166.18 CAV26597.1 - 0.0033 17.7 0.9 0.0058 16.9 0.9 1.4 1 0 0 1 1 1 1 TSC-22/dip/bun family PDDEXK_9 PF08011.11 CAV26597.1 - 0.0075 16.2 2.5 0.72 9.8 1.1 2.1 2 0 0 2 2 2 2 PD-(D/E)XK nuclease superfamily Chibby PF14645.6 CAV26597.1 - 0.017 15.6 0.5 0.02 15.3 0.5 1.2 1 0 0 1 1 1 0 Chibby family HTH_29 PF13551.6 CAV26597.1 - 0.033 14.2 0.0 0.046 13.8 0.0 1.3 1 0 0 1 1 1 0 Winged helix-turn helix Peptidase_M16 PF00675.20 CAV26598.1 - 0.18 11.8 1.8 6.1 6.8 0.1 2.3 2 0 0 2 2 2 0 Insulinase (Peptidase family M16) Transposase_20 PF02371.16 CAV26600.1 - 3.8e-21 75.2 0.1 8.4e-21 74.1 0.1 1.6 1 0 0 1 1 1 1 Transposase IS116/IS110/IS902 family DEDD_Tnp_IS110 PF01548.17 CAV26600.1 - 6.8e-15 55.3 0.2 2.1e-14 53.7 0.0 1.8 2 0 0 2 2 2 1 Transposase GFA PF04828.14 CAV26603.1 - 7e-18 64.8 0.3 1e-17 64.2 0.3 1.2 1 0 0 1 1 1 1 Glutathione-dependent formaldehyde-activating enzyme AAA_21 PF13304.6 CAV26609.1 - 1.8e-14 54.3 0.0 1.1e-09 38.6 0.0 2.5 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system DUF4435 PF14491.6 CAV26609.1 - 1.3e-12 48.1 1.9 2.3e-12 47.3 1.8 1.5 1 1 0 1 1 1 1 Protein of unknown function (DUF4435) AAA_15 PF13175.6 CAV26609.1 - 6.9e-08 32.6 5.3 2.7e-06 27.4 0.0 3.0 3 0 0 3 3 3 2 AAA ATPase domain ABC_tran PF00005.27 CAV26609.1 - 0.00016 22.2 0.2 0.0035 17.9 0.2 2.4 1 1 0 1 1 1 1 ABC transporter SMC_N PF02463.19 CAV26609.1 - 0.00026 20.5 0.0 0.0096 15.4 0.0 2.7 2 1 0 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 CAV26609.1 - 0.026 14.8 0.1 0.63 10.3 0.0 2.8 3 0 0 3 3 3 0 AAA domain AAA_29 PF13555.6 CAV26609.1 - 0.11 12.2 1.2 0.27 11.0 0.2 2.1 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA_23 PF13476.6 CAV26609.1 - 0.43 11.1 2.4 0.82 10.1 0.1 2.2 2 0 0 2 2 2 0 AAA domain MatE PF01554.18 CAV26611.1 - 3.8e-66 221.7 40.2 1.8e-34 118.7 11.9 3.1 3 1 1 4 4 4 2 MatE Polysacc_synt_C PF14667.6 CAV26611.1 - 9.8e-12 45.1 11.5 9.8e-12 45.1 11.5 4.8 2 2 2 4 4 4 2 Polysaccharide biosynthesis C-terminal domain LysE PF01810.18 CAV26613.1 - 1.7e-35 122.2 9.8 2.1e-35 122.0 9.8 1.1 1 0 0 1 1 1 1 LysE type translocator TMEM208_SND2 PF05620.11 CAV26613.1 - 0.00077 19.3 0.2 0.00077 19.3 0.2 2.1 1 1 1 2 2 2 1 SRP-independent targeting protein 2/TMEM208 TerC PF03741.16 CAV26613.1 - 0.001 18.8 6.1 0.0039 16.9 6.1 1.9 1 1 0 1 1 1 1 Integral membrane protein TerC family Colicin_V PF02674.16 CAV26613.1 - 1.1 9.2 13.9 0.035 14.1 4.0 2.6 1 1 1 2 2 2 0 Colicin V production protein Herpes_UL49_5 PF05702.11 CAV26613.1 - 9.1 6.5 8.2 1.1 9.4 0.1 2.9 2 1 1 3 3 3 0 Herpesvirus UL49.5 envelope/tegument protein CA_like PF10563.9 CAV26616.1 - 5.2e-69 231.8 0.6 7.6e-69 231.3 0.6 1.2 1 0 0 1 1 1 1 Putative carbonic anhydrase Plasmod_dom_1 PF09715.10 CAV26618.1 - 0.066 13.3 0.0 6.3 6.9 0.0 2.6 2 0 0 2 2 2 0 Plasmodium protein of unknown function (Plasmod_dom_1) Glyoxalase PF00903.25 CAV26620.1 - 3e-11 43.6 0.1 2.5e-10 40.6 0.1 2.0 1 1 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_2 PF12681.7 CAV26620.1 - 0.00027 20.9 0.2 0.0013 18.7 0.2 1.9 1 1 0 1 1 1 1 Glyoxalase-like domain CppA_N PF14506.6 CAV26620.1 - 0.00041 20.4 0.0 0.012 15.7 0.0 2.0 1 1 1 2 2 2 1 CppA N-terminal Glyoxalase_4 PF13669.6 CAV26620.1 - 0.00053 20.2 0.0 0.00079 19.7 0.0 1.3 1 1 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_3 PF13468.6 CAV26620.1 - 0.0084 16.2 0.0 0.011 15.8 0.0 1.6 1 1 0 1 1 1 1 Glyoxalase-like domain tRNA-synt_1b PF00579.25 CAV26621.1 - 3.2e-54 184.3 0.0 3.9e-54 184.0 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) PALP PF00291.25 CAV26625.1 - 4.5e-60 203.5 0.0 6.2e-60 203.1 0.0 1.2 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme HTH_18 PF12833.7 CAV26627.1 - 3.4e-16 59.3 1.0 5.4e-16 58.6 0.1 1.8 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_AraC PF00165.23 CAV26627.1 - 5.9e-12 45.4 0.1 8.5e-08 32.1 0.1 2.8 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family AraC_N PF06719.13 CAV26627.1 - 0.0021 17.7 0.0 0.0037 16.9 0.0 1.5 1 0 0 1 1 1 1 AraC-type transcriptional regulator N-terminus SurA_N PF09312.11 CAV26627.1 - 0.072 13.2 0.0 0.15 12.2 0.1 1.5 1 1 0 1 1 1 0 SurA N-terminal domain PBP PF01161.20 CAV26629.1 - 7.5e-36 123.4 0.0 9.6e-36 123.0 0.0 1.1 1 0 0 1 1 1 1 Phosphatidylethanolamine-binding protein DUF3404 PF11884.8 CAV26631.1 - 1.2e-92 309.9 3.9 2.3e-92 309.0 3.9 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3404) HisKA PF00512.25 CAV26631.1 - 7.4e-06 25.9 0.1 2.7e-05 24.1 0.0 2.1 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain HATPase_c PF02518.26 CAV26631.1 - 1.9e-05 25.1 0.0 3.6e-05 24.2 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_2 PF13581.6 CAV26631.1 - 0.0035 17.3 0.0 0.0079 16.2 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-like ATPase domain HATPase_c_5 PF14501.6 CAV26631.1 - 0.013 15.4 0.2 0.037 13.9 0.2 1.7 1 1 0 1 1 1 0 GHKL domain DUF3211 PF11485.8 CAV26631.1 - 0.14 12.4 0.0 1.3 9.2 0.0 2.2 1 1 0 2 2 2 0 Protein of unknown function (DUF3211) Trans_reg_C PF00486.28 CAV26632.1 - 2e-23 82.3 0.1 8e-23 80.3 0.1 1.9 2 0 0 2 2 2 1 Transcriptional regulatory protein, C terminal Response_reg PF00072.24 CAV26632.1 - 7.3e-16 58.3 0.0 1.1e-15 57.7 0.0 1.3 1 0 0 1 1 1 1 Response regulator receiver domain HTH_11 PF08279.12 CAV26632.1 - 0.0087 16.0 0.4 0.025 14.5 0.0 1.9 2 0 0 2 2 2 1 HTH domain NRho PF16733.5 CAV26632.1 - 0.044 13.8 0.1 0.17 12.0 0.0 2.0 2 0 0 2 2 2 0 Rhomboid N-terminal domain DUF2861 PF11060.8 CAV26634.1 - 1.7e-79 267.1 3.4 1.9e-79 267.0 3.4 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2861) Glyco_hydro_129 PF11308.8 CAV26636.1 - 1.9e-156 520.2 0.6 3.4e-156 519.4 0.6 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases related to GH101 family, GH129 DUF4479 PF14794.6 CAV26636.1 - 0.26 11.2 1.0 3.5 7.5 0.5 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4479) LysR_substrate PF03466.20 CAV26637.1 - 6.6e-32 110.6 0.0 1e-31 110.0 0.0 1.3 1 0 0 1 1 1 1 LysR substrate binding domain HTH_1 PF00126.27 CAV26637.1 - 8.5e-21 73.7 0.1 1.5e-20 72.9 0.1 1.4 1 0 0 1 1 1 1 Bacterial regulatory helix-turn-helix protein, lysR family HTH_Tnp_ISL3 PF13542.6 CAV26637.1 - 0.0016 17.8 0.0 0.0035 16.7 0.0 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain of transposase family ISL3 HTH_30 PF13556.6 CAV26637.1 - 0.003 17.3 0.1 0.0069 16.2 0.1 1.6 1 0 0 1 1 1 1 PucR C-terminal helix-turn-helix domain MarR PF01047.22 CAV26637.1 - 0.0083 16.0 0.1 0.029 14.3 0.0 1.9 2 0 0 2 2 2 1 MarR family HTH_Crp_2 PF13545.6 CAV26637.1 - 0.02 14.8 0.1 0.18 11.8 0.1 2.5 3 0 0 3 3 3 0 Crp-like helix-turn-helix domain HTH_8 PF02954.19 CAV26637.1 - 0.031 14.1 0.0 0.078 12.8 0.0 1.7 1 0 0 1 1 1 0 Bacterial regulatory protein, Fis family HTH_IclR PF09339.10 CAV26637.1 - 0.048 13.5 0.1 0.19 11.5 0.1 2.0 2 0 0 2 2 2 0 IclR helix-turn-helix domain MarR_2 PF12802.7 CAV26637.1 - 0.099 12.5 0.0 0.24 11.3 0.0 1.6 1 0 0 1 1 1 0 MarR family HTH_24 PF13412.6 CAV26637.1 - 0.13 11.8 0.0 0.34 10.5 0.0 1.8 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding HTH_28 PF13518.6 CAV26637.1 - 0.16 12.1 0.0 0.31 11.2 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain HlyD_D23 PF16576.5 CAV26639.1 - 1.6e-22 79.8 11.3 6.9e-20 71.2 11.3 2.2 1 1 0 1 1 1 1 Barrel-sandwich domain of CusB or HlyD membrane-fusion HlyD_3 PF13437.6 CAV26639.1 - 1.4e-19 70.8 8.3 7.7e-18 65.2 0.1 3.5 2 1 1 3 3 3 1 HlyD family secretion protein Biotin_lipoyl_2 PF13533.6 CAV26639.1 - 4.7e-16 58.3 4.4 4.2e-15 55.3 0.3 3.3 3 0 0 3 3 3 1 Biotin-lipoyl like HlyD PF00529.20 CAV26639.1 - 4.2e-09 36.2 0.2 9.9e-09 35.0 0.2 1.8 1 1 0 1 1 1 1 HlyD membrane-fusion protein of T1SS HlyD_2 PF12700.7 CAV26639.1 - 1.2e-05 24.3 0.5 0.00021 20.1 0.5 2.7 1 1 0 1 1 1 1 HlyD family secretion protein Biotin_lipoyl PF00364.22 CAV26639.1 - 0.0011 18.8 0.1 1.8 8.5 0.1 2.5 2 0 0 2 2 2 2 Biotin-requiring enzyme YqfD PF06898.11 CAV26639.1 - 0.034 13.0 0.7 0.46 9.3 0.1 2.1 2 0 0 2 2 2 0 Putative stage IV sporulation protein YqfD GAS PF13851.6 CAV26639.1 - 0.055 12.8 13.9 0.041 13.2 11.2 1.9 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding Spc7 PF08317.11 CAV26639.1 - 0.068 12.0 13.1 0.096 11.6 13.1 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein PTS_EIIA_1 PF00358.20 CAV26639.1 - 0.07 12.9 0.4 1.6 8.5 0.0 2.8 2 1 1 3 3 3 0 phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1 DUF4407 PF14362.6 CAV26639.1 - 0.077 12.3 15.1 0.11 11.8 15.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF3584 PF12128.8 CAV26639.1 - 0.2 9.2 15.0 0.27 8.7 15.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Atx10homo_assoc PF09759.9 CAV26639.1 - 0.23 11.5 2.4 0.36 10.9 0.4 2.1 1 1 1 2 2 2 0 Spinocerebellar ataxia type 10 protein domain Tropomyosin_1 PF12718.7 CAV26639.1 - 0.29 11.3 13.5 0.5 10.5 13.5 1.3 1 0 0 1 1 1 0 Tropomyosin like Atg14 PF10186.9 CAV26639.1 - 0.39 9.7 6.3 0.53 9.3 6.3 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 MscS_porin PF12795.7 CAV26639.1 - 0.69 9.4 27.5 0.18 11.3 11.4 2.1 1 1 1 2 2 2 0 Mechanosensitive ion channel porin domain IFT57 PF10498.9 CAV26639.1 - 1 8.3 10.8 1.5 7.7 10.8 1.2 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 BRE1 PF08647.11 CAV26639.1 - 2.1 8.5 16.1 1.2 9.3 6.1 2.3 2 0 0 2 2 2 0 BRE1 E3 ubiquitin ligase Plasmid_RAQPRD PF09686.10 CAV26639.1 - 5.1 7.4 15.0 0.1 12.8 1.3 3.1 1 1 1 3 3 3 0 Plasmid protein of unknown function (Plasmid_RAQPRD) MFS_1 PF07690.16 CAV26641.1 - 7.5e-44 150.1 30.1 7.5e-44 150.1 30.1 1.4 2 0 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CAV26641.1 - 5.1e-08 32.2 12.7 5.1e-08 32.2 12.7 2.2 2 0 0 2 2 2 1 Sugar (and other) transporter MFS_1_like PF12832.7 CAV26641.1 - 0.035 13.0 22.0 0.015 14.2 8.6 2.4 2 0 0 2 2 2 0 MFS_1 like family FliE PF02049.18 CAV26641.1 - 0.045 13.9 0.6 0.082 13.1 0.6 1.3 1 0 0 1 1 1 0 Flagellar hook-basal body complex protein FliE Response_reg PF00072.24 CAV26643.1 - 2.6e-14 53.3 0.1 5e-14 52.4 0.1 1.5 1 0 0 1 1 1 1 Response regulator receiver domain Hpt PF01627.23 CAV26644.1 - 2e-08 34.4 0.1 2.6e-08 34.0 0.1 1.2 1 0 0 1 1 1 1 Hpt domain DUF2383 PF09537.10 CAV26644.1 - 0.069 13.5 0.5 1.1 9.7 0.5 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF2383) Sigma70_r2 PF04542.14 CAV26646.1 - 4.5e-16 58.4 0.0 7.8e-16 57.6 0.0 1.4 1 0 0 1 1 1 1 Sigma-70 region 2 Sigma70_r4 PF04545.16 CAV26646.1 - 7.7e-10 38.1 0.2 1.3e-08 34.2 0.0 2.3 2 0 0 2 2 2 1 Sigma-70, region 4 Sigma70_r1_2 PF00140.20 CAV26646.1 - 5.4e-07 29.5 0.2 1.2e-06 28.4 0.2 1.7 1 0 0 1 1 1 1 Sigma-70 factor, region 1.2 Cadherin_5 PF17892.1 CAV26650.1 - 1.9e-210 681.9 137.9 2.3e-26 91.6 7.1 13.4 14 0 0 14 14 14 11 Cadherin-like domain Big_9 PF17963.1 CAV26650.1 - 2e-133 435.5 189.5 1.3e-18 67.5 10.7 14.5 14 1 0 14 14 13 11 Bacterial Ig domain Cadherin_4 PF17803.1 CAV26650.1 - 3.5e-110 360.7 172.3 5.2e-19 68.6 10.1 14.4 14 1 0 14 14 12 10 Bacterial cadherin-like domain Cadherin_3 PF16184.5 CAV26650.1 - 9.7e-10 38.4 23.7 0.084 12.9 0.6 9.1 8 0 0 8 8 8 3 Cadherin-like HU-CCDC81_bac_2 PF18175.1 CAV26650.1 - 2.6e-06 27.2 10.3 3.4 7.6 0.0 7.2 7 0 0 7 7 7 1 CCDC81-like prokaryotic HU domain 2 Bactofilin PF04519.13 CAV26650.1 - 0.00024 21.3 10.9 0.42 10.9 0.3 5.7 3 2 1 4 4 4 2 Polymer-forming cytoskeletal DUF4367 PF14285.6 CAV26650.1 - 0.0017 18.8 7.2 40 4.7 0.1 6.0 4 1 0 5 5 5 0 Domain of unknown function (DUF4367) fn3_6 PF17766.1 CAV26650.1 - 0.04 14.1 0.1 5.7 7.2 0.0 2.8 2 0 0 2 2 2 0 Fibronectin type-III domain DUF3386 PF11866.8 CAV26650.1 - 0.054 13.0 0.1 19 4.7 0.0 3.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3386) TMEM71 PF15121.6 CAV26650.1 - 0.058 13.1 1.6 21 4.7 0.0 4.2 4 0 0 4 4 4 0 TMEM71 protein family DUF2742 PF10888.8 CAV26650.1 - 0.1 12.8 0.1 62 4.0 0.0 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF2742) Invasin_D3 PF09134.10 CAV26650.1 - 0.38 11.1 0.1 0.38 11.1 0.1 12.4 9 4 2 12 12 12 0 Invasin, domain 3 MetallophosN PF16371.5 CAV26650.1 - 2 8.7 18.0 3.3 8.1 0.1 7.8 8 0 0 8 8 7 0 N terminal of Calcineurin-like phosphoesterase Cadherin_5 PF17892.1 CAV26652.1 - 0 2974.9 569.6 2.6e-27 94.7 5.1 46.4 46 2 0 46 46 46 44 Cadherin-like domain Big_9 PF17963.1 CAV26652.1 - 0 2028.2 757.2 1.6e-18 67.3 6.8 49.5 47 4 1 49 49 49 45 Bacterial Ig domain Cadherin_4 PF17803.1 CAV26652.1 - 0 1714.5 711.7 1.7e-16 60.6 8.7 50.1 48 3 0 48 48 48 43 Bacterial cadherin-like domain CarboxypepD_reg PF13620.6 CAV26652.1 - 1.3e-08 35.0 6.6 1.3e-08 35.0 6.6 20.6 20 1 0 20 20 20 2 Carboxypeptidase regulatory-like domain Bactofilin PF04519.13 CAV26652.1 - 2.4e-08 34.2 77.5 0.59 10.5 0.0 22.0 20 4 1 22 22 22 4 Polymer-forming cytoskeletal DUF4114 PF13448.6 CAV26652.1 - 2e-05 25.3 1.4 2e-05 25.3 1.4 7.2 7 1 0 7 7 7 1 Domain of unknown function (DUF4114) Cadherin_3 PF16184.5 CAV26652.1 - 2.6e-05 24.2 146.7 0.41 10.7 0.4 33.5 31 5 3 34 34 34 7 Cadherin-like CarbopepD_reg_2 PF13715.6 CAV26652.1 - 0.00022 21.2 1.3 0.00022 21.2 1.3 13.0 13 0 0 13 13 13 2 CarboxypepD_reg-like domain FixH PF05751.11 CAV26652.1 - 0.088 12.8 1.4 1.3e+02 2.5 0.0 6.4 6 1 1 7 7 7 0 FixH FlaC_arch PF05377.11 CAV26654.1 - 0.082 13.3 0.4 0.45 10.9 0.1 2.2 2 1 0 2 2 2 0 Flagella accessory protein C (FlaC) HlyD_3 PF13437.6 CAV26656.1 - 2.2e-16 60.5 0.0 1.5e-13 51.4 0.0 2.6 2 0 0 2 2 2 2 HlyD family secretion protein HlyD_D23 PF16576.5 CAV26656.1 - 9.1e-09 34.8 0.3 1.5e-05 24.3 0.0 2.5 2 1 0 2 2 2 2 Barrel-sandwich domain of CusB or HlyD membrane-fusion HlyD PF00529.20 CAV26656.1 - 0.0017 18.2 0.0 0.0024 17.7 0.0 1.3 1 0 0 1 1 1 1 HlyD membrane-fusion protein of T1SS Biotin_lipoyl_2 PF13533.6 CAV26656.1 - 0.0023 17.7 3.6 0.0036 17.1 0.2 3.0 3 0 0 3 3 3 1 Biotin-lipoyl like Biotin_lipoyl PF00364.22 CAV26656.1 - 0.0027 17.5 0.5 0.25 11.2 0.1 3.4 3 0 0 3 3 3 1 Biotin-requiring enzyme OEP PF02321.18 CAV26656.1 - 0.0071 16.2 3.2 0.0071 16.2 3.2 1.8 2 0 0 2 2 2 1 Outer membrane efflux protein RNA_pol_Rpb1_5 PF04998.17 CAV26656.1 - 2.4 7.5 4.5 4 6.8 4.5 1.4 1 0 0 1 1 1 0 RNA polymerase Rpb1, domain 5 Response_reg PF00072.24 CAV26658.1 - 1.2e-23 83.5 0.9 5.7e-23 81.2 0.2 2.3 2 0 0 2 2 2 1 Response regulator receiver domain DUF2536 PF10750.9 CAV26658.1 - 0.041 13.8 0.0 0.3 11.0 0.0 2.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2536) DUF2489 PF10675.9 CAV26658.1 - 0.049 13.6 2.5 0.14 12.1 0.2 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2489) OEP PF02321.18 CAV26659.1 - 8.1e-54 182.3 17.9 1.8e-33 116.0 5.5 2.1 2 0 0 2 2 2 2 Outer membrane efflux protein Baculo_LEF-11 PF06385.12 CAV26659.1 - 0.041 14.4 0.7 7 7.2 0.4 2.6 2 0 0 2 2 2 0 Baculovirus LEF-11 protein ABC_membrane PF00664.23 CAV26661.1 - 2.3e-10 40.6 15.6 2.9e-10 40.3 15.6 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 CAV26661.1 - 8.8e-10 39.2 0.0 3e-09 37.5 0.0 1.9 1 1 0 1 1 1 1 ABC transporter cobW PF02492.19 CAV26661.1 - 0.00063 19.4 0.0 0.0021 17.7 0.0 1.9 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain AAA PF00004.29 CAV26661.1 - 0.00075 19.9 1.3 0.009 16.4 0.4 2.9 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 CAV26661.1 - 0.00093 19.6 0.1 0.0043 17.5 0.1 2.1 1 1 0 1 1 1 1 AAA ATPase domain AAA_29 PF13555.6 CAV26661.1 - 0.0024 17.6 0.0 0.0056 16.4 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain IstB_IS21 PF01695.17 CAV26661.1 - 0.0029 17.4 0.1 0.033 13.9 0.0 2.4 2 0 0 2 2 2 1 IstB-like ATP binding protein AAA_22 PF13401.6 CAV26661.1 - 0.0033 17.7 0.0 0.015 15.6 0.0 2.1 1 1 0 1 1 1 1 AAA domain RsgA_GTPase PF03193.16 CAV26661.1 - 0.008 16.1 0.2 0.03 14.2 0.0 2.0 2 0 0 2 2 2 1 RsgA GTPase AAA_23 PF13476.6 CAV26661.1 - 0.0091 16.5 0.4 0.029 14.9 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.6 CAV26661.1 - 0.019 15.5 0.0 0.063 13.8 0.0 2.0 1 1 0 1 1 1 0 AAA domain NACHT PF05729.12 CAV26661.1 - 0.021 14.7 0.0 0.31 11.0 0.0 2.5 2 0 0 2 2 2 0 NACHT domain Sigma54_activat PF00158.26 CAV26661.1 - 0.027 14.2 0.0 0.069 12.8 0.0 1.6 1 0 0 1 1 1 0 Sigma-54 interaction domain Zeta_toxin PF06414.12 CAV26661.1 - 0.065 12.5 0.1 0.17 11.1 0.0 1.7 1 1 1 2 2 2 0 Zeta toxin AAA_5 PF07728.14 CAV26661.1 - 0.11 12.5 0.0 0.49 10.4 0.0 2.2 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) APS_kinase PF01583.20 CAV26661.1 - 0.13 12.2 0.0 0.27 11.1 0.0 1.5 1 0 0 1 1 1 0 Adenylylsulphate kinase ATP-synt_ab PF00006.25 CAV26661.1 - 0.14 11.8 0.0 0.27 10.9 0.0 1.5 1 0 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain SP24 PF16504.5 CAV26661.1 - 0.19 11.7 3.8 12 5.9 0.2 3.0 3 0 0 3 3 3 0 Putative virion membrane protein of plant and insect virus Wzy_C PF04932.15 CAV26661.1 - 0.73 9.4 10.6 0.3 10.7 5.4 2.8 2 1 0 2 2 2 0 O-Antigen ligase ABC_tran PF00005.27 CAV26662.1 - 1.1e-18 68.1 0.0 1.8e-18 67.4 0.0 1.3 1 0 0 1 1 1 1 ABC transporter ABC_membrane PF00664.23 CAV26662.1 - 6.6e-10 39.1 20.9 1e-09 38.5 20.9 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region AAA_21 PF13304.6 CAV26662.1 - 7.5e-05 22.7 0.0 0.014 15.3 0.0 2.3 2 0 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system Rad17 PF03215.15 CAV26662.1 - 0.0035 17.3 0.0 0.029 14.3 0.0 2.3 2 0 0 2 2 2 1 Rad17 P-loop domain AAA_23 PF13476.6 CAV26662.1 - 0.0089 16.6 0.0 0.017 15.6 0.0 1.4 1 0 0 1 1 1 1 AAA domain DLIC PF05783.11 CAV26662.1 - 0.013 14.4 0.0 0.019 13.8 0.0 1.2 1 0 0 1 1 1 0 Dynein light intermediate chain (DLIC) RsgA_GTPase PF03193.16 CAV26662.1 - 0.013 15.4 0.0 0.026 14.4 0.0 1.4 1 0 0 1 1 1 0 RsgA GTPase PduV-EutP PF10662.9 CAV26662.1 - 0.016 15.0 0.2 0.043 13.6 0.0 1.8 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_22 PF13401.6 CAV26662.1 - 0.02 15.2 0.5 0.082 13.2 0.5 2.1 1 1 0 1 1 1 0 AAA domain S1FA PF04689.13 CAV26662.1 - 0.021 14.9 0.1 0.054 13.6 0.1 1.6 1 0 0 1 1 1 0 DNA binding protein S1FA AAA_28 PF13521.6 CAV26662.1 - 0.048 13.9 0.1 0.084 13.1 0.1 1.4 1 0 0 1 1 1 0 AAA domain AAA PF00004.29 CAV26662.1 - 0.076 13.4 0.0 0.29 11.5 0.0 2.0 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Zeta_toxin PF06414.12 CAV26662.1 - 0.076 12.3 0.0 0.14 11.4 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin IstB_IS21 PF01695.17 CAV26662.1 - 0.15 11.8 0.1 1.7 8.4 0.1 2.2 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA_18 PF13238.6 CAV26662.1 - 0.16 12.5 0.0 0.31 11.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain ATPase_2 PF01637.18 CAV26662.1 - 0.16 11.9 0.0 0.35 10.7 0.0 1.5 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea DUF2207 PF09972.9 CAV26662.1 - 4.2 6.0 5.9 9.8 4.8 0.3 2.2 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) Response_reg PF00072.24 CAV26666.1 - 1.5e-49 166.9 2.6 5.1e-25 87.8 0.5 2.9 2 0 0 2 2 2 2 Response regulator receiver domain HATPase_c PF02518.26 CAV26666.1 - 3.7e-31 107.9 0.2 1.3e-30 106.2 0.2 2.0 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 CAV26666.1 - 2.1e-20 72.5 0.0 2.1e-20 72.5 0.0 3.2 4 0 0 4 4 4 1 His Kinase A (phospho-acceptor) domain HATPase_c_3 PF13589.6 CAV26666.1 - 0.0014 18.5 0.0 0.0039 17.0 0.0 1.8 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Porin_4 PF13609.6 CAV26669.1 - 0.00034 20.5 7.6 0.00066 19.5 7.6 1.6 1 1 0 1 1 1 1 Gram-negative porin TPR_16 PF13432.6 CAV26671.1 - 2e-06 28.3 0.2 0.0058 17.3 0.4 2.5 1 1 1 2 2 2 2 Tetratricopeptide repeat HEAT_2 PF13646.6 CAV26671.1 - 4.7e-06 26.9 0.5 0.00023 21.5 0.2 3.3 1 1 3 4 4 4 1 HEAT repeats TPR_14 PF13428.6 CAV26671.1 - 4.9e-06 26.9 1.0 0.02 15.6 0.0 3.7 1 1 2 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.6 CAV26671.1 - 2.3e-05 24.8 4.2 0.2 12.2 0.0 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 CAV26671.1 - 0.00035 20.5 0.4 16 5.9 0.0 4.2 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_17 PF13431.6 CAV26671.1 - 0.0019 18.5 0.7 1.1 9.8 0.0 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat Cnd1 PF12717.7 CAV26671.1 - 0.0044 17.1 0.6 0.31 11.1 0.1 3.1 1 1 1 2 2 2 1 non-SMC mitotic condensation complex subunit 1 TPR_11 PF13414.6 CAV26671.1 - 0.0047 16.6 0.2 0.79 9.5 0.0 2.7 2 1 1 3 3 3 1 TPR repeat HEAT PF02985.22 CAV26671.1 - 0.0049 17.0 0.0 0.12 12.7 0.0 3.0 3 0 0 3 3 2 1 HEAT repeat ANAPC3 PF12895.7 CAV26671.1 - 0.084 13.1 0.9 5.8 7.2 0.0 3.0 1 1 2 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 Cohesin_HEAT PF12765.7 CAV26671.1 - 0.086 13.2 0.0 0.32 11.3 0.0 2.0 1 0 0 1 1 1 0 HEAT repeat associated with sister chromatid cohesion DUF4179 PF13786.6 CAV26671.1 - 0.16 12.4 0.8 0.37 11.3 0.8 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4179) DUF4240 PF14024.6 CAV26671.1 - 0.17 12.1 3.3 0.52 10.5 0.1 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF4240) TrbC PF04956.13 CAV26671.1 - 0.18 12.0 2.7 0.39 11.0 2.7 1.5 1 0 0 1 1 1 0 TrbC/VIRB2 family TPR_9 PF13371.6 CAV26671.1 - 0.21 11.8 2.2 7 6.9 0.2 2.9 2 1 2 4 4 3 0 Tetratricopeptide repeat 4HB_MCP_1 PF12729.7 CAV26671.1 - 6.6 6.2 8.7 11 5.5 1.2 3.3 3 1 1 4 4 4 0 Four helix bundle sensory module for signal transduction Radical_SAM PF04055.21 CAV26673.1 - 9.3e-12 45.6 0.0 1.5e-11 45.0 0.0 1.3 1 0 0 1 1 1 1 Radical SAM superfamily SPASM PF13186.6 CAV26673.1 - 6.2e-08 33.0 0.3 1.6e-07 31.7 0.3 1.7 1 0 0 1 1 1 1 Iron-sulfur cluster-binding domain Fer4_12 PF13353.6 CAV26673.1 - 6.8e-05 23.2 0.0 0.00016 21.9 0.0 1.6 1 0 0 1 1 1 1 4Fe-4S single cluster domain Fer4_14 PF13394.6 CAV26673.1 - 0.0021 18.2 0.0 0.0065 16.6 0.0 1.8 2 0 0 2 2 2 1 4Fe-4S single cluster domain DUF5040 PF16443.5 CAV26673.1 - 0.049 13.0 0.0 0.084 12.3 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF5040) FGE-sulfatase PF03781.16 CAV26674.1 - 1.7e-50 172.0 2.9 3.4e-49 167.8 2.9 2.0 1 1 0 1 1 1 1 Sulfatase-modifying factor enzyme 1 Phosphodiest PF01663.22 CAV26676.1 - 3.4e-69 234.1 1.1 4.1e-69 233.9 1.1 1.0 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.23 CAV26676.1 - 2e-06 27.4 0.0 0.00011 21.7 0.0 2.9 2 1 0 2 2 2 1 Sulfatase DUF5127 PF17168.4 CAV26676.1 - 0.012 15.5 0.9 0.76 9.5 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF5127) DUF229 PF02995.17 CAV26676.1 - 0.13 10.9 0.0 0.15 10.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF229) KHA PF11834.8 CAV26676.1 - 0.21 11.7 0.6 0.65 10.1 0.0 2.1 2 0 0 2 2 2 0 KHA, dimerisation domain of potassium ion channel LysR_substrate PF03466.20 CAV26678.1 - 2.1e-19 69.7 0.0 3e-19 69.2 0.0 1.2 1 0 0 1 1 1 1 LysR substrate binding domain HTH_1 PF00126.27 CAV26678.1 - 2.6e-18 65.7 0.0 5.4e-18 64.7 0.0 1.5 1 0 0 1 1 1 1 Bacterial regulatory helix-turn-helix protein, lysR family Cro PF09048.10 CAV26678.1 - 0.034 14.2 0.0 0.068 13.2 0.0 1.4 1 0 0 1 1 1 0 Cro Sigma70_r4 PF04545.16 CAV26678.1 - 0.16 11.5 0.0 0.44 10.1 0.0 1.7 1 0 0 1 1 1 0 Sigma-70, region 4 BatD PF13584.6 CAV26680.1 - 6.9e-24 84.5 1.3 1.1e-23 83.9 1.3 1.3 1 0 0 1 1 1 1 Oxygen tolerance TRAPPC10 PF12584.8 CAV26680.1 - 0.00068 19.4 0.0 0.0037 17.0 0.0 1.9 1 1 1 2 2 2 1 Trafficking protein particle complex subunit 10, TRAPPC10 Peptidase_A4 PF01828.17 CAV26680.1 - 0.011 15.2 1.1 0.11 12.0 0.0 2.4 3 0 0 3 3 3 0 Peptidase A4 family VWA_2 PF13519.6 CAV26682.1 - 6.2e-14 52.5 0.0 2.4e-13 50.7 0.0 2.0 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.28 CAV26682.1 - 2.3e-06 27.9 0.0 4.2e-06 27.1 0.0 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain Fis1_TPR_C PF14853.6 CAV26682.1 - 0.28 11.3 1.1 2.8 8.1 0.4 2.4 2 0 0 2 2 2 0 Fis1 C-terminal tetratricopeptide repeat TPR_2 PF07719.17 CAV26682.1 - 1.8 8.9 11.2 14 6.0 0.1 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat VWA PF00092.28 CAV26683.1 - 7.8e-24 84.9 1.5 9.9e-24 84.5 1.5 1.1 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.6 CAV26683.1 - 1.5e-18 67.4 1.1 4.1e-18 66.0 0.8 1.8 2 0 0 2 2 2 1 von Willebrand factor type A domain VWA_CoxE PF05762.14 CAV26683.1 - 0.058 12.8 2.4 1.1 8.6 2.4 2.2 1 1 0 1 1 1 0 VWA domain containing CoxE-like protein DUF4381 PF14316.6 CAV26685.1 - 1.1e-25 90.6 2.1 1.4e-25 90.2 2.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4381) Ycf4 PF02392.16 CAV26685.1 - 0.036 13.6 0.0 0.052 13.1 0.0 1.2 1 0 0 1 1 1 0 Ycf4 DUF2062 PF09835.9 CAV26685.1 - 0.097 12.5 0.3 0.15 11.9 0.3 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2062) DUF58 PF01882.18 CAV26687.1 - 2.8e-20 72.4 0.0 4.9e-20 71.6 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function DUF58 AAA_3 PF07726.11 CAV26688.1 - 4.5e-61 204.5 0.1 7.5e-61 203.7 0.1 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_2 PF17863.1 CAV26688.1 - 2.1e-17 62.7 0.0 5.6e-17 61.4 0.0 1.8 2 0 0 2 2 2 1 AAA lid domain AAA_5 PF07728.14 CAV26688.1 - 2.2e-13 50.4 0.0 5.1e-13 49.2 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) MCM PF00493.23 CAV26688.1 - 3.5e-05 23.0 0.1 0.0003 20.0 0.1 2.4 1 1 0 1 1 1 1 MCM P-loop domain Mg_chelatase PF01078.21 CAV26688.1 - 7e-05 22.3 0.2 0.0023 17.3 0.1 2.2 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI Sigma54_activat PF00158.26 CAV26688.1 - 0.00023 20.9 0.1 0.0018 18.0 0.0 2.1 2 0 0 2 2 2 1 Sigma-54 interaction domain AAA PF00004.29 CAV26688.1 - 0.0015 19.0 0.0 0.007 16.8 0.0 2.3 3 1 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) AAA_30 PF13604.6 CAV26688.1 - 0.04 13.6 0.0 0.12 12.1 0.0 1.8 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.6 CAV26688.1 - 0.088 13.2 0.1 0.29 11.5 0.0 1.9 2 1 0 2 2 2 0 AAA ATPase domain TPR_1 PF00515.28 CAV26690.1 - 1.8e-14 52.9 2.9 2.6e-07 30.2 0.0 3.8 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_8 PF13181.6 CAV26690.1 - 1.1e-13 50.2 5.0 7.2e-06 25.8 0.0 4.8 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.17 CAV26690.1 - 2.5e-12 45.9 4.9 6e-05 22.9 0.0 4.2 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_12 PF13424.6 CAV26690.1 - 6.4e-12 45.6 2.8 1.2e-08 35.1 1.2 3.4 2 1 0 2 2 2 2 Tetratricopeptide repeat TPR_7 PF13176.6 CAV26690.1 - 1.3e-11 43.7 1.6 8.2e-05 22.4 0.0 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat Cytochrome_C554 PF13435.6 CAV26690.1 - 3.2e-11 44.0 37.8 0.00059 20.7 0.5 6.6 5 1 0 6 6 6 3 Cytochrome c554 and c-prime TPR_19 PF14559.6 CAV26690.1 - 7.4e-10 39.2 5.0 1e-07 32.3 0.4 2.9 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_14 PF13428.6 CAV26690.1 - 1.2e-09 38.2 0.6 0.044 14.6 0.0 3.9 2 1 1 3 3 3 3 Tetratricopeptide repeat Cytochrome_C7 PF14522.6 CAV26690.1 - 2.5e-09 37.0 44.4 0.027 14.5 6.2 5.4 3 2 2 5 5 5 5 Cytochrome c7 and related cytochrome c Paired_CXXCH_1 PF09699.10 CAV26690.1 - 1e-08 34.8 38.2 0.0067 16.2 5.8 7.1 5 1 0 6 6 6 4 Doubled CXXCH motif (Paired_CXXCH_1) TPR_11 PF13414.6 CAV26690.1 - 9.3e-08 31.6 2.0 9.3e-08 31.6 2.0 3.5 3 1 1 4 4 4 1 TPR repeat TPR_17 PF13431.6 CAV26690.1 - 2.5e-07 30.6 3.1 0.0088 16.4 0.4 4.8 4 0 0 4 4 4 2 Tetratricopeptide repeat Cytochrom_c3_2 PF14537.6 CAV26690.1 - 4.1e-07 30.4 46.3 0.11 13.0 22.0 5.2 3 2 2 5 5 5 2 Cytochrome c3 TPR_10 PF13374.6 CAV26690.1 - 4.6e-07 29.5 6.2 0.00055 19.7 0.0 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.6 CAV26690.1 - 3.5e-06 27.6 3.9 0.0068 17.0 0.7 3.3 1 1 1 3 3 3 3 Tetratricopeptide repeat Cytochrom_C552 PF02335.15 CAV26690.1 - 3.7e-06 26.1 30.9 0.0015 17.5 5.6 4.8 2 1 3 5 5 5 3 Cytochrome c552 TPR_15 PF13429.6 CAV26690.1 - 5.3e-06 25.9 2.6 8.8e-05 21.8 2.9 3.0 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_6 PF13174.6 CAV26690.1 - 6.1e-06 26.5 1.6 0.64 10.8 0.0 3.8 3 0 0 3 3 3 2 Tetratricopeptide repeat ANAPC3 PF12895.7 CAV26690.1 - 8.8e-05 22.7 4.6 0.0019 18.4 1.0 3.9 2 1 3 5 5 4 2 Anaphase-promoting complex, cyclosome, subunit 3 Cytochrom_CIII PF02085.16 CAV26690.1 - 0.0062 16.9 41.9 2.1 8.7 0.3 5.4 4 1 1 5 5 5 2 Class III cytochrome C family BTAD PF03704.17 CAV26690.1 - 0.0068 16.8 0.0 0.018 15.5 0.0 1.7 1 0 0 1 1 1 1 Bacterial transcriptional activator domain TPR_4 PF07721.14 CAV26690.1 - 0.01 16.4 0.1 7.4 7.5 0.0 3.1 3 0 0 3 3 2 0 Tetratricopeptide repeat NARP1 PF12569.8 CAV26690.1 - 0.052 12.5 0.5 0.079 11.8 0.5 1.2 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 TPR_MalT PF17874.1 CAV26690.1 - 0.11 11.9 2.2 3.3 7.0 0.0 2.2 1 1 1 2 2 2 0 MalT-like TPR region Sulfatase PF00884.23 CAV26692.1 - 3.1e-63 214.0 0.1 4.3e-63 213.6 0.1 1.2 1 0 0 1 1 1 1 Sulfatase Sulfatase_C PF14707.6 CAV26692.1 - 1.4e-08 35.5 0.4 4.6e-08 33.8 0.1 1.9 2 0 0 2 2 2 1 C-terminal region of aryl-sulfatase Phosphodiest PF01663.22 CAV26692.1 - 0.0018 18.0 0.1 0.02 14.5 0.0 2.1 2 0 0 2 2 2 1 Type I phosphodiesterase / nucleotide pyrophosphatase DUF4994 PF16385.5 CAV26692.1 - 0.0031 17.4 0.0 0.034 14.1 0.0 2.6 4 0 0 4 4 4 1 Domain of unknown function IcmF_C PF06744.12 CAV26692.1 - 0.014 15.0 0.0 0.025 14.2 0.0 1.4 1 0 0 1 1 1 0 Type VI secretion protein IcmF C-terminal Sulfatase PF00884.23 CAV26694.1 - 7.5e-65 219.3 0.2 9.4e-65 219.0 0.2 1.1 1 0 0 1 1 1 1 Sulfatase Sulfatase_C PF14707.6 CAV26694.1 - 0.0006 20.6 0.0 0.0014 19.4 0.0 1.6 1 0 0 1 1 1 1 C-terminal region of aryl-sulfatase Phosphodiest PF01663.22 CAV26694.1 - 0.0021 17.7 0.1 0.2 11.2 0.0 2.5 2 1 0 2 2 2 2 Type I phosphodiesterase / nucleotide pyrophosphatase DUF2057 PF09829.9 CAV26696.1 - 5.8e-54 183.2 2.3 7e-54 182.9 2.3 1.0 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2057) Acetyltransf_10 PF13673.7 CAV26698.1 - 3.4e-24 85.2 0.0 3.8e-24 85.0 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 CAV26698.1 - 1.1e-19 70.8 0.0 1.4e-19 70.5 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 CAV26698.1 - 8.1e-14 51.8 0.0 1.3e-13 51.1 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.7 CAV26698.1 - 2e-11 44.7 0.0 2.4e-11 44.5 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 CAV26698.1 - 7.1e-11 42.5 0.0 9.2e-11 42.1 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.6 CAV26698.1 - 1.3e-05 24.9 0.0 1.7e-05 24.6 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 CAV26698.1 - 0.00011 22.1 0.0 0.00023 21.1 0.0 1.6 1 1 0 1 1 1 1 FR47-like protein Acetyltransf_9 PF13527.7 CAV26698.1 - 0.00019 21.5 0.0 0.00035 20.7 0.0 1.6 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 CAV26698.1 - 0.025 14.7 0.1 0.062 13.4 0.1 1.8 1 1 1 2 2 2 0 GCN5-related N-acetyl-transferase DUF4821 PF16092.5 CAV26698.1 - 0.031 13.9 0.0 0.042 13.5 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4821) Fasciclin PF02469.22 CAV26700.1 - 6e-37 126.7 0.1 7.7e-37 126.4 0.1 1.1 1 0 0 1 1 1 1 Fasciclin domain Ribosomal_S4e PF00900.20 CAV26700.1 - 0.033 14.1 0.2 0.058 13.3 0.2 1.5 1 0 0 1 1 1 0 Ribosomal family S4e DUF3994 PF13159.6 CAV26700.1 - 0.047 14.3 0.8 0.073 13.6 0.8 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF3994) Propep_M14 PF02244.16 CAV26700.1 - 0.071 13.5 0.0 0.22 11.9 0.0 1.8 1 0 0 1 1 1 0 Carboxypeptidase activation peptide Acetyltransf_10 PF13673.7 CAV26701.1 - 2.9e-20 72.5 0.0 3.7e-20 72.2 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 CAV26701.1 - 3.4e-14 53.0 0.1 4.9e-14 52.5 0.1 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 CAV26701.1 - 2.1e-13 50.5 0.1 2.7e-13 50.2 0.1 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_4 PF13420.7 CAV26701.1 - 0.00067 19.8 0.0 0.0013 18.9 0.0 1.5 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 CAV26701.1 - 0.003 17.7 0.0 0.0051 16.9 0.0 1.4 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase Acetyltransf_9 PF13527.7 CAV26701.1 - 0.0053 16.8 0.2 0.017 15.2 0.1 1.8 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Cupin_2 PF07883.11 CAV26703.1 - 1.5e-09 37.5 0.2 1.9e-09 37.1 0.2 1.2 1 0 0 1 1 1 1 Cupin domain Cupin_3 PF05899.12 CAV26703.1 - 0.00051 19.7 0.1 0.00067 19.3 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF861) YjzC PF14168.6 CAV26703.1 - 0.013 15.8 0.0 0.019 15.3 0.0 1.4 1 0 0 1 1 1 0 YjzC-like protein Ectoine_synth PF06339.12 CAV26703.1 - 0.047 13.9 0.0 0.058 13.6 0.0 1.2 1 0 0 1 1 1 0 Ectoine synthase AraC_binding PF02311.19 CAV26703.1 - 0.059 13.3 0.0 0.069 13.0 0.0 1.2 1 0 0 1 1 1 0 AraC-like ligand binding domain Imp-YgjV PF10688.9 CAV26705.1 - 5.9e-48 162.7 14.1 6.6e-48 162.5 14.1 1.0 1 0 0 1 1 1 1 Bacterial inner membrane protein PMT_2 PF13231.6 CAV26705.1 - 0.033 14.4 7.6 0.031 14.5 6.8 1.3 1 1 0 1 1 1 0 Dolichyl-phosphate-mannose-protein mannosyltransferase PhzC-PhzF PF02567.16 CAV26707.1 - 1.3e-60 205.3 0.0 1.5e-60 205.1 0.0 1.0 1 0 0 1 1 1 1 Phenazine biosynthesis-like protein DAP_epimerase PF01678.19 CAV26707.1 - 0.047 13.9 0.1 0.24 11.6 0.1 1.9 2 0 0 2 2 2 0 Diaminopimelate epimerase Pro_racemase PF05544.11 CAV26707.1 - 0.15 11.1 0.1 0.22 10.5 0.1 1.2 1 0 0 1 1 1 0 Proline racemase LysE PF01810.18 CAV26709.1 - 6.7e-30 104.0 14.1 8.8e-30 103.6 14.1 1.1 1 0 0 1 1 1 1 LysE type translocator SBP_bac_8 PF13416.6 CAV26711.1 - 7.8e-16 58.7 0.2 9.8e-16 58.4 0.2 1.1 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_6 PF13343.6 CAV26711.1 - 1.1e-12 47.9 0.1 1.6e-12 47.4 0.1 1.1 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein EAL PF00563.20 CAV26713.1 - 8.8e-62 208.7 0.3 4.4e-61 206.4 0.0 2.3 3 0 0 3 3 3 1 EAL domain GGDEF PF00990.21 CAV26713.1 - 4.2e-21 75.4 0.3 1.7e-20 73.4 0.0 2.2 3 0 0 3 3 3 1 Diguanylate cyclase, GGDEF domain Lipid_bd PF12888.7 CAV26713.1 - 0.081 13.4 0.4 10 6.6 0.0 2.8 2 0 0 2 2 2 0 Lipid-binding putative hydrolase GGDEF PF00990.21 CAV26714.1 - 7.6e-11 42.0 0.0 1.3e-10 41.3 0.0 1.3 1 0 0 1 1 1 1 Diguanylate cyclase, GGDEF domain Oxidored_molyb PF00174.19 CAV26716.1 - 0.00021 21.0 0.0 0.00093 18.8 0.0 1.8 1 1 0 1 1 1 1 Oxidoreductase molybdopterin binding domain Dimerisation2 PF16864.5 CAV26716.1 - 0.017 15.1 0.2 0.04 13.9 0.0 1.6 2 0 0 2 2 2 0 Dimerisation domain Cytochrom_C PF00034.21 CAV26718.1 - 6.8e-06 27.1 0.1 1.9e-05 25.7 0.1 1.7 1 1 0 1 1 1 1 Cytochrome c Cytochrome_CBB3 PF13442.6 CAV26718.1 - 4.3e-05 23.8 0.0 6.4e-05 23.2 0.0 1.2 1 0 0 1 1 1 1 Cytochrome C oxidase, cbb3-type, subunit III Paired_CXXCH_1 PF09699.10 CAV26718.1 - 0.11 12.3 0.1 0.17 11.7 0.1 1.3 1 0 0 1 1 1 0 Doubled CXXCH motif (Paired_CXXCH_1) PUNUT PF16913.5 CAV26718.1 - 0.18 11.0 0.0 0.24 10.6 0.0 1.2 1 0 0 1 1 1 0 Purine nucleobase transmembrane transport COX1 PF00115.20 CAV26719.1 - 9.7e-100 334.4 64.2 1.2e-99 334.1 64.2 1.1 1 0 0 1 1 1 1 Cytochrome C and Quinol oxidase polypeptide I FixO PF02433.15 CAV26721.1 - 6.3e-61 205.6 0.0 1.7e-59 200.9 0.0 1.9 1 1 1 2 2 2 2 Cytochrome C oxidase, mono-heme subunit/FixO Cytochrom_C PF00034.21 CAV26721.1 - 0.025 15.7 0.0 0.057 14.6 0.0 1.7 2 0 0 2 2 2 0 Cytochrome c Cytochrom_C PF00034.21 CAV26723.1 - 1.5e-18 67.7 0.0 1.4e-07 32.6 0.0 4.6 4 1 0 4 4 4 4 Cytochrome c Cytochrome_CBB3 PF13442.6 CAV26723.1 - 9.4e-18 64.3 2.4 1.4e-05 25.3 0.0 4.7 4 1 0 4 4 4 4 Cytochrome C oxidase, cbb3-type, subunit III Cytochrome_C7 PF14522.6 CAV26723.1 - 0.00015 21.7 0.0 11 6.1 0.0 3.3 3 0 0 3 3 3 3 Cytochrome c7 and related cytochrome c Paired_CXXCH_1 PF09699.10 CAV26723.1 - 0.00049 19.8 3.2 0.77 9.5 0.0 3.3 3 0 0 3 3 3 2 Doubled CXXCH motif (Paired_CXXCH_1) GSu_C4xC__C2xCH PF09698.10 CAV26723.1 - 0.05 14.4 6.4 6.9 7.5 0.3 3.7 3 0 0 3 3 3 0 Geobacter CxxxxCH...CXXCH motif (GSu_C4xC__C2xCH) Pas_Saposin PF09016.10 CAV26725.1 - 1.7e-38 130.8 0.2 1.8e-38 130.7 0.2 1.0 1 0 0 1 1 1 1 Pas factor saposin fold Ribosomal_L9_N PF01281.19 CAV26727.1 - 0.14 11.7 0.0 0.19 11.3 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L9, N-terminal domain Abhydrolase_1 PF00561.20 CAV26728.1 - 2.3e-21 76.6 0.1 2.5e-21 76.5 0.1 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 CAV26728.1 - 7.9e-05 22.0 0.0 0.00017 20.9 0.0 1.5 1 0 0 1 1 1 1 Serine aminopeptidase, S33 DUF3726 PF12525.8 CAV26731.1 - 3.1e-34 116.9 0.1 1.4e-32 111.7 0.0 2.4 2 0 0 2 2 2 1 Protein of unknown function (DUF3726) SEP PF08059.13 CAV26731.1 - 0.076 13.6 0.0 0.56 10.8 0.0 2.3 2 0 0 2 2 2 0 SEP domain Borrelia_lipo_1 PF05714.11 CAV26733.1 - 0.061 13.1 0.1 0.11 12.2 0.1 1.3 1 0 0 1 1 1 0 Borrelia burgdorferi virulent strain associated lipoprotein Creatininase PF02633.14 CAV26733.1 - 0.081 12.4 0.0 0.17 11.3 0.0 1.5 1 0 0 1 1 1 0 Creatinine amidohydrolase DASH_Duo1 PF08651.10 CAV26733.1 - 0.088 12.6 1.2 0.21 11.4 1.2 1.6 1 0 0 1 1 1 0 DASH complex subunit Duo1 BCCT PF02028.17 CAV26735.1 - 5.4e-143 476.9 40.2 6.6e-143 476.7 40.2 1.0 1 0 0 1 1 1 1 BCCT, betaine/carnitine/choline family transporter Peptidase_M19 PF01244.21 CAV26738.1 - 1.4e-70 238.0 0.0 1.8e-70 237.7 0.0 1.0 1 0 0 1 1 1 1 Membrane dipeptidase (Peptidase family M19) Aldedh PF00171.22 CAV26741.1 - 4.6e-149 496.9 3.6 5.3e-149 496.7 3.6 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Ribonuc_L-PSP PF01042.21 CAV26744.1 - 5e-23 81.4 0.2 5.9e-23 81.2 0.2 1.1 1 0 0 1 1 1 1 Endoribonuclease L-PSP LysR_substrate PF03466.20 CAV26746.1 - 2.1e-37 128.5 0.1 3.3e-37 127.9 0.1 1.3 1 0 0 1 1 1 1 LysR substrate binding domain HTH_1 PF00126.27 CAV26746.1 - 8e-17 60.9 0.2 1.4e-16 60.2 0.2 1.4 1 0 0 1 1 1 1 Bacterial regulatory helix-turn-helix protein, lysR family Antimicrobial_4 PF08024.11 CAV26746.1 - 0.13 12.4 0.1 0.37 10.9 0.1 1.8 1 0 0 1 1 1 0 Ant antimicrobial peptide ATP-synt_I PF03899.15 CAV26750.1 - 0.0001 22.6 3.9 0.00012 22.4 3.2 1.4 1 1 0 1 1 1 1 ATP synthase I chain DUF2953 PF11167.8 CAV26750.1 - 0.28 11.3 3.6 1.2 9.2 0.0 2.6 2 1 1 3 3 3 0 Protein of unknown function (DUF2953) ATP-synt_A PF00119.20 CAV26752.1 - 3.2e-55 187.4 18.4 3.7e-55 187.1 18.4 1.0 1 0 0 1 1 1 1 ATP synthase A chain DUF485 PF04341.12 CAV26752.1 - 1.1 9.2 7.7 3.2 7.8 4.7 2.8 3 0 0 3 3 3 0 Protein of unknown function, DUF485 ATP-synt_C PF00137.21 CAV26754.1 - 8.4e-09 35.7 7.9 1.2e-08 35.2 7.9 1.2 1 0 0 1 1 1 1 ATP synthase subunit C ATP-synt_B PF00430.18 CAV26757.1 - 4.4e-25 88.3 6.1 5.3e-25 88.0 6.1 1.1 1 0 0 1 1 1 1 ATP synthase B/B' CF(0) Mt_ATP-synt_B PF05405.14 CAV26757.1 - 2.5e-07 30.5 2.1 2.9e-07 30.3 2.1 1.1 1 0 0 1 1 1 1 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) HrpE PF06188.12 CAV26757.1 - 0.061 13.2 9.5 0.067 13.1 9.5 1.1 1 0 0 1 1 1 0 HrpE/YscL/FliH and V-type ATPase subunit E DUF4359 PF14271.6 CAV26757.1 - 0.24 12.2 1.4 3.3 8.5 0.1 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4359) ESM4 PF15952.5 CAV26757.1 - 0.73 10.2 5.1 4.9 7.5 5.2 2.0 1 1 0 1 1 1 0 Enhancer of split M4 family Fmp27_WPPW PF10359.9 CAV26757.1 - 2 7.2 7.1 2.4 6.9 7.1 1.2 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain OSCP PF00213.18 CAV26760.1 - 9.2e-43 146.3 1.4 1e-42 146.2 1.4 1.0 1 0 0 1 1 1 1 ATP synthase delta (OSCP) subunit ATP-synt_ab PF00006.25 CAV26762.1 - 3.5e-73 245.8 0.1 8.8e-73 244.5 0.1 1.7 2 0 0 2 2 2 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_C PF00306.27 CAV26762.1 - 7.6e-45 152.3 0.2 1.2e-44 151.7 0.2 1.3 1 0 0 1 1 1 1 ATP synthase alpha/beta chain, C terminal domain ATP-synt_ab_N PF02874.23 CAV26762.1 - 1.4e-11 44.7 0.6 3.7e-11 43.4 0.6 1.7 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain ATPase PF06745.13 CAV26762.1 - 2.5e-05 23.7 0.0 4.3e-05 23.0 0.0 1.3 1 0 0 1 1 1 1 KaiC ATPase_2 PF01637.18 CAV26762.1 - 0.0049 16.8 0.0 0.0087 16.0 0.0 1.4 1 0 0 1 1 1 1 ATPase domain predominantly from Archaea HAS-barrel PF09378.10 CAV26762.1 - 0.0092 16.1 0.2 0.036 14.2 0.0 2.2 2 1 0 2 2 2 1 HAS barrel domain Coat_F PF07875.12 CAV26762.1 - 0.14 12.4 0.0 0.5 10.6 0.0 1.9 2 0 0 2 2 2 0 Coat F domain DUF3892 PF13031.6 CAV26762.1 - 0.55 10.9 2.1 5.7 7.6 0.0 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF3892) ATP-synt PF00231.19 CAV26765.1 - 1.2e-96 323.7 1.4 1.4e-96 323.5 1.4 1.0 1 0 0 1 1 1 1 ATP synthase ATP-synt_ab PF00006.25 CAV26767.1 - 8.3e-63 211.9 0.0 1.2e-62 211.4 0.0 1.2 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_N PF02874.23 CAV26767.1 - 1.3e-19 70.4 1.0 3.3e-19 69.2 1.0 1.7 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain T3SS_ATPase_C PF18269.1 CAV26767.1 - 0.0035 17.2 0.3 0.057 13.3 0.4 2.7 2 1 0 2 2 2 1 T3SS EscN ATPase C-terminal domain RNA_helicase PF00910.22 CAV26767.1 - 0.13 12.6 0.1 0.31 11.4 0.0 1.6 2 0 0 2 2 2 0 RNA helicase YdaS_antitoxin PF15943.5 CAV26767.1 - 0.15 11.9 0.0 0.32 10.9 0.0 1.6 1 0 0 1 1 1 0 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT Phlebovirus_NSM PF07246.11 CAV26767.1 - 0.21 11.0 0.1 0.61 9.4 0.0 1.7 2 0 0 2 2 2 0 Phlebovirus nonstructural protein NS-M ATP-synt_DE_N PF02823.16 CAV26769.1 - 2.3e-24 85.1 0.0 3.8e-24 84.4 0.0 1.3 1 0 0 1 1 1 1 ATP synthase, Delta/Epsilon chain, beta-sandwich domain ATP-synt_DE PF00401.20 CAV26769.1 - 2.3e-09 37.3 8.8 3.1e-09 37.0 8.8 1.2 1 0 0 1 1 1 1 ATP synthase, Delta/Epsilon chain, long alpha-helix domain S4_2 PF13275.6 CAV26770.1 - 5e-22 77.5 0.0 9.3e-22 76.6 0.0 1.4 1 0 0 1 1 1 1 S4 domain YL1 PF05764.13 CAV26770.1 - 0.0046 17.1 17.8 0.0065 16.6 17.8 1.2 1 0 0 1 1 1 1 YL1 nuclear protein CLN3 PF02487.17 CAV26770.1 - 0.0056 15.8 0.1 0.007 15.5 0.1 1.1 1 0 0 1 1 1 1 CLN3 protein Radial_spoke PF04712.12 CAV26770.1 - 0.025 13.6 9.7 0.051 12.5 9.7 1.5 1 0 0 1 1 1 0 Radial spokehead-like protein S4 PF01479.25 CAV26770.1 - 0.071 12.8 0.1 0.14 11.9 0.1 1.4 1 0 0 1 1 1 0 S4 domain CDC45 PF02724.14 CAV26770.1 - 0.072 11.4 9.3 0.078 11.3 9.3 1.1 1 0 0 1 1 1 0 CDC45-like protein RR_TM4-6 PF06459.12 CAV26770.1 - 0.086 12.7 13.1 0.089 12.6 13.1 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF913 PF06025.12 CAV26770.1 - 0.44 9.5 5.9 0.46 9.4 5.9 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) NARP1 PF12569.8 CAV26770.1 - 0.95 8.3 23.6 1.3 7.9 23.6 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 NPR3 PF03666.13 CAV26770.1 - 1.1 8.0 14.3 1.1 7.9 14.3 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 DUF3807 PF12720.7 CAV26770.1 - 1.8 8.8 17.0 3 8.1 17.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) Menin PF05053.13 CAV26770.1 - 2.1 6.6 9.6 2.6 6.3 9.6 1.1 1 0 0 1 1 1 0 Menin Rtf2 PF04641.12 CAV26770.1 - 2.6 7.4 20.1 3.8 6.8 20.1 1.2 1 0 0 1 1 1 0 Rtf2 RING-finger Presenilin PF01080.17 CAV26770.1 - 4.1 6.1 13.4 5 5.8 13.4 1.1 1 0 0 1 1 1 0 Presenilin DUF5427 PF10310.9 CAV26770.1 - 5.1 5.9 17.3 6.3 5.6 17.3 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5427) SLC12 PF03522.15 CAV26770.1 - 9.9 5.1 12.7 12 4.8 12.7 1.1 1 0 0 1 1 1 0 Solute carrier family 12 ACR_tran PF00873.19 CAV26774.1 - 1e-297 990.1 31.2 1.2e-297 989.9 31.2 1.0 1 0 0 1 1 1 1 AcrB/AcrD/AcrF family MMPL PF03176.15 CAV26774.1 - 2.9e-13 49.4 34.1 9.8e-12 44.4 12.8 2.6 3 0 0 3 3 3 2 MMPL family SecD_SecF PF02355.16 CAV26774.1 - 3.3e-06 26.6 15.2 3.3e-06 26.6 15.2 3.0 3 0 0 3 3 3 2 Protein export membrane protein Patched PF02460.18 CAV26774.1 - 2.5e-05 22.6 15.5 4.5e-05 21.8 15.5 1.4 1 0 0 1 1 1 1 Patched family HlyD_D23 PF16576.5 CAV26776.1 - 1.3e-09 37.6 0.0 5.9e-09 35.5 0.0 1.9 1 1 0 1 1 1 1 Barrel-sandwich domain of CusB or HlyD membrane-fusion Biotin_lipoyl_2 PF13533.6 CAV26776.1 - 3e-07 30.2 0.0 1.6e-06 27.9 0.0 2.3 2 0 0 2 2 2 1 Biotin-lipoyl like HlyD_3 PF13437.6 CAV26776.1 - 4.6e-07 30.5 0.1 0.00024 21.7 0.0 2.9 3 0 0 3 3 3 1 HlyD family secretion protein OEP PF02321.18 CAV26776.1 - 0.0084 15.9 6.0 0.0084 15.9 6.0 1.7 2 0 0 2 2 2 1 Outer membrane efflux protein DUF5061 PF16587.5 CAV26776.1 - 0.059 13.4 0.0 0.22 11.6 0.0 1.9 1 0 0 1 1 1 0 17 kDa common-antigen outer membrane protein T2SSN PF01203.19 CAV26776.1 - 0.068 13.4 1.1 0.96 9.6 0.2 2.1 2 0 0 2 2 2 0 Type II secretion system (T2SS), protein N LPAM_1 PF08139.12 CAV26776.1 - 0.32 11.6 2.7 0.69 10.5 2.7 1.6 1 0 0 1 1 1 0 Prokaryotic membrane lipoprotein lipid attachment site OEP PF02321.18 CAV26778.1 - 2.9e-49 167.4 40.7 1.1e-25 90.5 17.0 2.2 2 0 0 2 2 2 2 Outer membrane efflux protein RE_BstXI PF09552.10 CAV26778.1 - 0.035 13.3 0.1 0.22 10.7 0.0 2.0 2 0 0 2 2 2 0 BstXI restriction endonuclease RRP36 PF06102.12 CAV26778.1 - 0.26 11.3 5.1 0.52 10.3 0.1 2.9 3 0 0 3 3 3 0 rRNA biogenesis protein RRP36 Sas6_CC PF18594.1 CAV26778.1 - 1.8 8.4 3.8 3.5 7.5 3.8 1.4 1 0 0 1 1 1 0 Sas6/XLF/XRCC4 coiled-coil domain CSD PF00313.22 CAV26780.1 - 6.2e-12 45.2 0.0 7.4e-12 44.9 0.0 1.1 1 0 0 1 1 1 1 'Cold-shock' DNA-binding domain OB_RNB PF08206.11 CAV26780.1 - 0.011 15.4 0.1 0.019 14.7 0.1 1.3 1 0 0 1 1 1 0 Ribonuclease B OB domain S1 PF00575.23 CAV26780.1 - 0.12 12.7 0.1 0.16 12.3 0.1 1.1 1 0 0 1 1 1 0 S1 RNA binding domain XhlA PF10779.9 CAV26781.1 - 0.25 11.6 3.8 0.17 12.1 0.4 2.5 2 0 0 2 2 2 0 Haemolysin XhlA DUF3829 PF12889.7 CAV26781.1 - 1.2 8.6 9.0 2 7.8 0.8 2.9 2 1 0 3 3 3 0 Protein of unknown function (DUF3829) Trans_reg_C PF00486.28 CAV26783.1 - 8.7e-13 48.2 0.0 1.5e-12 47.4 0.0 1.4 1 0 0 1 1 1 1 Transcriptional regulatory protein, C terminal HTH_1 PF00126.27 CAV26787.1 - 4.3e-10 39.4 0.0 1.2e-09 38.0 0.0 1.8 2 0 0 2 2 2 1 Bacterial regulatory helix-turn-helix protein, lysR family LysR_substrate PF03466.20 CAV26787.1 - 0.0021 17.5 0.0 0.0034 16.8 0.0 1.3 1 0 0 1 1 1 1 LysR substrate binding domain HTH_30 PF13556.6 CAV26787.1 - 0.14 11.9 0.0 0.34 10.8 0.0 1.6 1 0 0 1 1 1 0 PucR C-terminal helix-turn-helix domain Exonuc_VII_L PF02601.15 CAV26787.1 - 0.18 11.3 1.3 0.43 10.1 1.3 1.7 1 1 0 1 1 1 0 Exonuclease VII, large subunit CBAH PF02275.18 CAV26789.1 - 1.2e-34 120.4 0.0 1.5e-34 120.1 0.0 1.1 1 0 0 1 1 1 1 Linear amide C-N hydrolases, choloylglycine hydrolase family AAT PF03417.16 CAV26789.1 - 7e-06 25.9 0.0 9.4e-06 25.5 0.0 1.2 1 0 0 1 1 1 1 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase HTH_1 PF00126.27 CAV26791.1 - 9.5e-08 31.9 0.0 1.7e-07 31.1 0.0 1.4 1 0 0 1 1 1 1 Bacterial regulatory helix-turn-helix protein, lysR family LysR_substrate PF03466.20 CAV26791.1 - 3.9e-05 23.1 0.0 5.8e-05 22.6 0.0 1.2 1 0 0 1 1 1 1 LysR substrate binding domain Amidohydro_3 PF07969.11 CAV26792.1 - 4.1e-43 148.6 0.9 1.3e-42 146.9 0.9 1.8 1 1 0 1 1 1 1 Amidohydrolase family Amidohydro_1 PF01979.20 CAV26792.1 - 6.9e-08 32.2 1.1 9.1e-06 25.2 0.0 3.0 3 0 0 3 3 3 2 Amidohydrolase family PAS PF00989.25 CAV26792.1 - 0.0037 17.2 0.0 0.0074 16.3 0.0 1.5 1 0 0 1 1 1 1 PAS fold DMSP_lyase PF16867.5 CAV26794.1 - 0.0023 17.6 0.5 0.019 14.6 0.2 1.9 2 0 0 2 2 2 1 Dimethlysulfonioproprionate lyase DHR-2 PF06920.13 CAV26794.1 - 0.014 14.1 0.4 0.021 13.5 0.4 1.2 1 0 0 1 1 1 0 Dock homology region 2 YjeJ PF15922.5 CAV26794.1 - 0.038 13.2 0.4 0.05 12.8 0.4 1.2 1 0 0 1 1 1 0 YjeJ-like VPS9 PF02204.18 CAV26794.1 - 0.044 14.0 0.2 0.18 12.1 0.2 1.9 1 1 0 1 1 1 0 Vacuolar sorting protein 9 (VPS9) domain Endonuclease_1 PF04231.13 CAV26794.1 - 0.063 12.9 0.0 0.072 12.8 0.0 1.1 1 0 0 1 1 1 0 Endonuclease I DUF1804 PF08822.11 CAV26794.1 - 0.078 13.0 0.3 0.12 12.3 0.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1804) OprB PF04966.12 CAV26796.1 - 2.5e-18 66.7 12.2 3.4e-17 62.9 6.5 2.2 1 1 0 2 2 2 2 Carbohydrate-selective porin, OprB family ABC_tran PF00005.27 CAV26798.1 - 1.2e-59 200.7 0.1 5e-29 101.6 0.0 2.2 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 CAV26798.1 - 4.9e-12 45.8 1.1 3.6e-05 23.3 0.0 2.6 2 1 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 CAV26798.1 - 1.1e-11 45.2 5.9 3e-05 24.0 0.1 3.8 3 1 0 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system oligo_HPY PF08352.12 CAV26798.1 - 2e-10 41.0 0.0 0.00016 22.1 0.0 2.5 2 0 0 2 2 2 2 Oligopeptide/dipeptide transporter, C-terminal region AAA_16 PF13191.6 CAV26798.1 - 1.1e-09 38.9 0.1 0.00013 22.4 0.0 2.4 2 0 0 2 2 2 2 AAA ATPase domain AAA_7 PF12775.7 CAV26798.1 - 1.6e-07 31.0 0.9 0.0037 16.8 0.0 2.3 2 0 0 2 2 2 2 P-loop containing dynein motor region AAA_22 PF13401.6 CAV26798.1 - 3.3e-06 27.4 6.0 0.028 14.7 0.9 3.7 2 2 0 2 2 2 2 AAA domain AAA_29 PF13555.6 CAV26798.1 - 9.8e-06 25.2 2.5 0.092 12.5 0.1 2.4 2 0 0 2 2 2 2 P-loop containing region of AAA domain AIG1 PF04548.16 CAV26798.1 - 1.3e-05 24.6 2.0 0.015 14.6 0.2 2.3 2 0 0 2 2 2 2 AIG1 family Mg_chelatase PF01078.21 CAV26798.1 - 3.9e-05 23.1 0.6 0.29 10.5 0.0 2.9 4 0 0 4 4 3 2 Magnesium chelatase, subunit ChlI NB-ARC PF00931.22 CAV26798.1 - 5.6e-05 22.5 0.0 1.5 8.0 0.0 3.3 3 1 0 3 3 3 2 NB-ARC domain AAA_5 PF07728.14 CAV26798.1 - 0.0001 22.3 0.5 0.27 11.2 0.0 3.0 2 1 1 3 3 3 2 AAA domain (dynein-related subfamily) RsgA_GTPase PF03193.16 CAV26798.1 - 0.0011 18.9 2.0 0.93 9.4 0.1 2.5 2 0 0 2 2 2 2 RsgA GTPase SbcCD_C PF13558.6 CAV26798.1 - 0.0014 18.8 0.7 0.58 10.4 0.1 3.6 2 2 0 2 2 2 1 Putative exonuclease SbcCD, C subunit ATP-synt_ab PF00006.25 CAV26798.1 - 0.0037 17.0 0.0 3.2 7.4 0.0 2.3 2 0 0 2 2 2 2 ATP synthase alpha/beta family, nucleotide-binding domain Sigma54_activat PF00158.26 CAV26798.1 - 0.0071 16.1 4.9 0.15 11.7 0.0 2.9 4 0 0 4 4 2 1 Sigma-54 interaction domain DUF87 PF01935.17 CAV26798.1 - 0.0076 16.4 2.8 2.1 8.4 0.1 2.6 2 0 0 2 2 2 1 Helicase HerA, central domain AAA_25 PF13481.6 CAV26798.1 - 0.012 15.2 1.3 9.4 5.8 0.0 3.9 5 0 0 5 5 4 0 AAA domain AAA PF00004.29 CAV26798.1 - 0.012 16.0 2.3 3.2 8.2 0.0 3.4 3 1 0 3 3 2 0 ATPase family associated with various cellular activities (AAA) TniB PF05621.11 CAV26798.1 - 0.013 14.9 1.8 5.4 6.4 0.1 3.9 4 0 0 4 4 4 0 Bacterial TniB protein T2SSE PF00437.20 CAV26798.1 - 0.014 14.4 2.3 1 8.4 0.1 2.3 2 0 0 2 2 2 0 Type II/IV secretion system protein FtsK_SpoIIIE PF01580.18 CAV26798.1 - 0.021 14.2 0.7 3.4 7.0 0.0 2.3 2 0 0 2 2 2 0 FtsK/SpoIIIE family RNA_helicase PF00910.22 CAV26798.1 - 0.022 15.1 0.5 5.8 7.3 0.1 2.7 3 0 0 3 3 2 0 RNA helicase ATPase PF06745.13 CAV26798.1 - 0.023 14.1 1.0 11 5.3 0.2 3.1 3 0 0 3 3 3 0 KaiC APS_kinase PF01583.20 CAV26798.1 - 0.029 14.3 1.1 6 6.7 0.1 2.4 2 0 0 2 2 2 0 Adenylylsulphate kinase AAA_33 PF13671.6 CAV26798.1 - 0.03 14.5 0.2 8.4 6.6 0.1 2.6 2 0 0 2 2 2 0 AAA domain AAA_30 PF13604.6 CAV26798.1 - 0.035 13.8 0.1 5 6.8 0.0 3.0 2 1 0 2 2 2 0 AAA domain AAA_13 PF13166.6 CAV26798.1 - 0.047 12.3 0.1 0.78 8.3 0.0 2.5 3 0 0 3 3 3 0 AAA domain G-alpha PF00503.20 CAV26798.1 - 0.048 12.8 0.1 2.6 7.1 0.0 2.1 2 0 0 2 2 2 0 G-protein alpha subunit NACHT PF05729.12 CAV26798.1 - 0.049 13.6 5.7 0.97 9.3 0.0 3.8 5 0 0 5 5 5 0 NACHT domain Rad17 PF03215.15 CAV26798.1 - 0.067 13.1 0.1 12 5.8 0.0 2.3 2 0 0 2 2 2 0 Rad17 P-loop domain PRK PF00485.18 CAV26798.1 - 0.077 12.7 0.3 2.1 8.0 0.0 2.2 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family AAA_18 PF13238.6 CAV26798.1 - 0.14 12.7 0.1 2.6 8.6 0.0 2.6 2 0 0 2 2 2 0 AAA domain IstB_IS21 PF01695.17 CAV26798.1 - 0.15 11.8 4.2 9.5 5.9 0.0 3.4 4 0 0 4 4 4 0 IstB-like ATP binding protein AAA_24 PF13479.6 CAV26798.1 - 0.2 11.3 3.0 10 5.8 0.1 2.4 2 0 0 2 2 2 0 AAA domain AAA_15 PF13175.6 CAV26798.1 - 0.26 10.9 0.6 15 5.2 0.0 2.6 3 0 0 3 3 3 0 AAA ATPase domain Pox_A32 PF04665.12 CAV26798.1 - 0.39 10.1 3.9 4.4 6.7 0.1 2.9 3 0 0 3 3 3 0 Poxvirus A32 protein Zeta_toxin PF06414.12 CAV26798.1 - 0.4 9.9 1.0 23 4.2 0.1 2.3 2 0 0 2 2 2 0 Zeta toxin MMR_HSR1 PF01926.23 CAV26798.1 - 0.43 10.7 1.8 16 5.7 0.1 2.6 2 0 0 2 2 2 0 50S ribosome-binding GTPase Hpr_kinase_C PF07475.12 CAV26798.1 - 1.5 8.4 5.1 3.1 7.3 0.1 2.7 3 0 0 3 3 3 0 HPr Serine kinase C-terminal domain BPD_transp_1 PF00528.22 CAV26799.1 - 4.5e-27 95.0 9.9 4.5e-27 95.0 9.9 2.0 2 1 0 2 2 2 1 Binding-protein-dependent transport system inner membrane component OppC_N PF12911.7 CAV26799.1 - 8.8e-09 35.2 0.7 8.8e-09 35.2 0.7 3.2 4 1 0 4 4 4 1 N-terminal TM domain of oligopeptide transport permease C BPD_transp_1 PF00528.22 CAV26800.1 - 2.6e-35 121.8 14.1 2.6e-35 121.8 14.1 1.8 2 0 0 2 2 2 1 Binding-protein-dependent transport system inner membrane component BCCT PF02028.17 CAV26800.1 - 0.003 16.1 7.1 0.003 16.1 7.1 1.9 2 0 0 2 2 2 1 BCCT, betaine/carnitine/choline family transporter SBP_bac_5 PF00496.22 CAV26801.1 - 7.2e-77 258.9 9.0 9.8e-77 258.4 9.0 1.2 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 5 Middle Exo_endo_phos PF03372.23 CAV26802.1 - 4.4e-10 39.5 0.0 1.1e-09 38.1 0.0 1.7 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.6 CAV26802.1 - 0.019 14.8 1.7 0.24 11.2 1.7 2.5 1 1 0 1 1 1 0 Endonuclease-reverse transcriptase OMP_b-brl PF13505.6 CAV26803.1 - 1.2e-21 77.6 5.7 1.5e-21 77.3 5.7 1.0 1 0 0 1 1 1 1 Outer membrane protein beta-barrel domain OmpA_membrane PF01389.17 CAV26803.1 - 5.3e-12 45.8 0.1 5.9e-12 45.7 0.1 1.1 1 0 0 1 1 1 1 OmpA-like transmembrane domain Trans_reg_C PF00486.28 CAV26804.1 - 7.2e-11 42.0 0.0 1e-10 41.5 0.0 1.2 1 0 0 1 1 1 1 Transcriptional regulatory protein, C terminal RbsD_FucU PF05025.13 CAV26805.1 - 7.8e-48 162.3 0.2 8.8e-48 162.1 0.2 1.0 1 0 0 1 1 1 1 RbsD / FucU transport protein family ABC_tran PF00005.27 CAV26806.1 - 4.5e-59 198.9 0.8 1.2e-31 110.0 0.1 2.3 2 0 0 2 2 2 2 ABC transporter AAA_21 PF13304.6 CAV26806.1 - 2.9e-10 40.4 0.1 0.016 15.1 0.0 3.1 2 1 1 3 3 3 3 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 CAV26806.1 - 0.0001 21.8 1.0 0.02 14.4 0.5 3.0 2 1 0 2 2 2 1 RecF/RecN/SMC N terminal domain RsgA_GTPase PF03193.16 CAV26806.1 - 0.0002 21.3 0.4 0.011 15.6 0.0 2.7 3 0 0 3 3 3 1 RsgA GTPase AAA_30 PF13604.6 CAV26806.1 - 0.00079 19.2 3.3 0.032 14.0 0.2 3.1 3 1 0 3 3 3 1 AAA domain ABC_ATPase PF09818.9 CAV26806.1 - 0.0023 16.8 2.8 0.33 9.7 0.1 3.7 3 1 0 3 3 3 1 Predicted ATPase of the ABC class TsaE PF02367.17 CAV26806.1 - 0.0026 17.8 0.8 0.92 9.5 0.1 2.4 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_29 PF13555.6 CAV26806.1 - 0.0042 16.8 1.1 0.0092 15.7 0.0 2.1 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_16 PF13191.6 CAV26806.1 - 0.023 15.1 0.2 0.88 9.9 0.1 2.5 2 1 0 2 2 2 0 AAA ATPase domain Rad17 PF03215.15 CAV26806.1 - 0.038 13.9 0.1 0.74 9.7 0.0 2.7 2 1 1 3 3 3 0 Rad17 P-loop domain AAA_23 PF13476.6 CAV26806.1 - 0.049 14.1 0.0 0.12 12.8 0.0 1.6 1 0 0 1 1 1 0 AAA domain DUF2813 PF11398.8 CAV26806.1 - 0.067 12.4 0.0 0.1 11.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2813) MMR_HSR1 PF01926.23 CAV26806.1 - 0.07 13.2 0.5 0.31 11.1 0.0 2.3 3 0 0 3 3 3 0 50S ribosome-binding GTPase Ploopntkinase3 PF18751.1 CAV26806.1 - 0.079 12.9 0.1 0.18 11.7 0.1 1.5 1 0 0 1 1 1 0 P-loop Nucleotide Kinase3 AAA_15 PF13175.6 CAV26806.1 - 0.08 12.6 0.2 0.34 10.6 0.0 1.9 2 0 0 2 2 2 0 AAA ATPase domain MukB PF04310.12 CAV26806.1 - 0.1 12.4 0.3 1.4 8.6 0.1 2.3 2 0 0 2 2 2 0 MukB N-terminal Zeta_toxin PF06414.12 CAV26806.1 - 0.19 11.0 0.3 20 4.4 0.0 2.3 2 0 0 2 2 2 0 Zeta toxin AAA_22 PF13401.6 CAV26806.1 - 0.24 11.7 8.4 0.27 11.5 0.6 4.0 3 2 0 3 3 3 0 AAA domain AAA PF00004.29 CAV26806.1 - 0.52 10.7 3.6 60 4.1 0.1 3.8 3 1 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) BPD_transp_2 PF02653.16 CAV26807.1 - 2.3e-52 177.8 40.8 3.5e-52 177.2 40.8 1.3 1 0 0 1 1 1 1 Branched-chain amino acid transport system / permease component Peripla_BP_4 PF13407.6 CAV26809.1 - 2e-59 201.3 3.6 2.4e-59 201.0 3.6 1.0 1 0 0 1 1 1 1 Periplasmic binding protein domain Peripla_BP_1 PF00532.21 CAV26809.1 - 1.6e-27 96.7 0.4 2e-27 96.3 0.4 1.0 1 0 0 1 1 1 1 Periplasmic binding proteins and sugar binding domain of LacI family Peripla_BP_6 PF13458.6 CAV26809.1 - 1.4e-11 44.7 0.6 5e-11 42.9 0.2 1.7 1 1 1 2 2 2 1 Periplasmic binding protein Peripla_BP_3 PF13377.6 CAV26809.1 - 2.3e-11 44.3 0.0 5.2e-11 43.1 0.1 1.5 2 0 0 2 2 2 1 Periplasmic binding protein-like domain PucR PF07905.11 CAV26809.1 - 0.0031 17.8 0.0 0.0083 16.4 0.0 1.7 1 1 0 1 1 1 1 Purine catabolism regulatory protein-like family FAD_binding_4 PF01565.23 CAV26809.1 - 0.01 15.5 0.1 0.036 13.8 0.0 1.9 2 0 0 2 2 2 0 FAD binding domain ANF_receptor PF01094.28 CAV26809.1 - 0.042 13.0 0.0 0.08 12.0 0.0 1.4 1 0 0 1 1 1 0 Receptor family ligand binding region ATPgrasp_N PF18130.1 CAV26809.1 - 0.069 13.7 0.1 0.49 11.0 0.0 2.3 2 0 0 2 2 2 0 ATP-grasp N-terminal domain PfkB PF00294.24 CAV26810.1 - 4.3e-74 249.5 2.1 4.9e-74 249.3 2.1 1.0 1 0 0 1 1 1 1 pfkB family carbohydrate kinase Phos_pyr_kin PF08543.12 CAV26810.1 - 1.7e-13 50.6 0.7 2.5e-13 50.0 0.7 1.2 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase DUF498 PF04430.14 CAV26810.1 - 0.0016 18.5 0.0 0.0034 17.4 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF498/DUF598) Carb_kinase PF01256.17 CAV26810.1 - 0.0064 16.0 0.3 0.011 15.2 0.3 1.3 1 0 0 1 1 1 1 Carbohydrate kinase Aldolase PF01081.19 CAV26810.1 - 0.046 13.1 0.3 0.18 11.2 0.1 2.0 2 0 0 2 2 2 0 KDPG and KHG aldolase Peripla_BP_3 PF13377.6 CAV26811.1 - 8.6e-41 140.0 0.0 1.9e-40 138.9 0.0 1.6 2 0 0 2 2 2 1 Periplasmic binding protein-like domain Peripla_BP_1 PF00532.21 CAV26811.1 - 1e-28 100.6 0.0 1.3e-28 100.2 0.0 1.1 1 0 0 1 1 1 1 Periplasmic binding proteins and sugar binding domain of LacI family LacI PF00356.21 CAV26811.1 - 7e-20 70.6 1.8 1.3e-19 69.7 1.8 1.5 1 0 0 1 1 1 1 Bacterial regulatory proteins, lacI family Peripla_BP_4 PF13407.6 CAV26811.1 - 1.7e-17 63.9 0.0 2.4e-17 63.4 0.0 1.2 1 0 0 1 1 1 1 Periplasmic binding protein domain HTH_Tnp_ISL3 PF13542.6 CAV26811.1 - 0.027 13.9 0.3 0.062 12.7 0.3 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain of transposase family ISL3 HTH_38 PF13936.6 CAV26811.1 - 0.042 13.6 0.2 1.1 9.0 0.0 2.6 2 0 0 2 2 2 0 Helix-turn-helix domain HTH_3 PF01381.22 CAV26811.1 - 0.16 12.1 0.0 0.55 10.3 0.0 1.9 1 1 1 2 2 2 0 Helix-turn-helix HTH_31 PF13560.6 CAV26811.1 - 0.19 12.1 0.1 0.43 11.0 0.1 1.6 2 0 0 2 2 2 0 Helix-turn-helix domain HTH_1 PF00126.27 CAV26811.1 - 0.21 11.5 0.9 4.6 7.3 0.1 2.5 2 0 0 2 2 2 0 Bacterial regulatory helix-turn-helix protein, lysR family EAL PF00563.20 CAV26813.1 - 1.8e-62 211.0 0.0 3.5e-62 210.0 0.0 1.5 2 0 0 2 2 2 1 EAL domain CSS-motif PF12792.7 CAV26813.1 - 3.6e-33 114.8 0.1 5e-33 114.4 0.1 1.2 1 0 0 1 1 1 1 CSS motif domain associated with EAL HIN PF02760.15 CAV26813.1 - 0.023 14.4 0.6 0.048 13.4 0.6 1.4 1 0 0 1 1 1 0 HIN-200/IF120x domain DHHC PF01529.20 CAV26813.1 - 0.85 9.7 3.4 5.6 7.1 0.2 2.4 2 0 0 2 2 2 0 DHHC palmitoyltransferase Band_7 PF01145.25 CAV26814.1 - 1.3e-24 87.2 6.6 1.3e-24 87.2 6.6 1.7 1 1 1 2 2 2 1 SPFH domain / Band 7 family Gal_mutarotas_3 PF18080.1 CAV26814.1 - 0.027 14.4 0.4 0.027 14.4 0.4 1.6 2 0 0 2 2 2 0 Galactose mutarotase-like fold domain YAF2_RYBP PF17219.3 CAV26816.1 - 0.0027 17.3 1.8 0.008 15.7 0.4 2.1 2 0 0 2 2 2 1 Yaf2/RYBP C-terminal binding motif DUF2306 PF10067.9 CAV26817.1 - 0.17 12.1 5.3 0.14 12.4 2.3 1.9 1 1 1 2 2 2 0 Predicted membrane protein (DUF2306) Molydop_binding PF01568.21 CAV26819.1 - 8.6e-24 83.7 0.0 1.2e-22 80.1 0.0 2.3 1 1 0 1 1 1 1 Molydopterin dinucleotide binding domain Molybdopterin PF00384.22 CAV26819.1 - 8.2e-23 81.0 0.0 1.3e-22 80.4 0.0 1.3 1 0 0 1 1 1 1 Molybdopterin oxidoreductase DUF4150 PF13665.6 CAV26820.1 - 7.5e-15 55.0 0.5 7.5e-15 55.0 0.5 1.4 2 0 0 2 2 2 1 Domain of unknown function (DUF4150) SpaA PF17802.1 CAV26820.1 - 0.075 13.4 0.1 0.1 13.0 0.1 1.2 1 0 0 1 1 1 0 Prealbumin-like fold domain LolA_2 PF16584.5 CAV26820.1 - 0.16 11.8 0.2 0.34 10.8 0.2 1.6 1 1 1 2 2 2 0 Outer membrane lipoprotein carrier protein LolA AHH PF14412.6 CAV26821.1 - 1.3e-22 80.0 0.4 1.3e-22 80.0 0.4 1.8 2 0 0 2 2 2 1 A nuclease family of the HNH/ENDO VII superfamily with conserved AHH Helo_like_N PF17111.5 CAV26822.1 - 0.025 14.0 0.0 0.04 13.3 0.0 1.3 1 0 0 1 1 1 0 Fungal N-terminal domain of STAND proteins Cas_TM1802 PF09484.10 CAV26822.1 - 0.092 11.5 0.1 0.13 11.0 0.1 1.1 1 0 0 1 1 1 0 CRISPR-associated protein TM1802 (cas_TM1802) DUF4150 PF13665.6 CAV26824.1 - 1.4e-16 60.6 0.8 4.2e-16 59.0 0.8 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF4150) AAA_3 PF07726.11 CAV26824.1 - 0.0085 15.9 0.0 0.02 14.7 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Y_Y_Y PF07495.13 CAV26824.1 - 0.04 13.9 0.0 0.11 12.4 0.0 1.8 1 0 0 1 1 1 0 Y_Y_Y domain CC2-LZ PF16516.5 CAV26824.1 - 0.16 12.4 0.1 0.4 11.1 0.1 1.7 1 0 0 1 1 1 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator DUF4417 PF14386.6 CAV26826.1 - 0.025 14.1 0.2 0.081 12.5 0.2 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4417) AHH PF14412.6 CAV26827.1 - 6.6e-16 58.4 3.6 7.9e-15 54.9 3.6 2.2 1 1 0 1 1 1 1 A nuclease family of the HNH/ENDO VII superfamily with conserved AHH DUF2969 PF11184.8 CAV26827.1 - 0.0074 16.7 0.1 0.018 15.5 0.1 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF2969) Importin_rep_6 PF18829.1 CAV26827.1 - 0.041 14.0 0.3 0.066 13.3 0.3 1.3 1 0 0 1 1 1 0 Importin repeat 6 Seryl_tRNA_N PF02403.22 CAV26827.1 - 0.057 13.6 0.1 0.13 12.5 0.1 1.5 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain CDC14 PF08045.11 CAV26828.1 - 0.15 11.2 0.0 0.18 10.9 0.0 1.1 1 0 0 1 1 1 0 Cell division control protein 14, SIN component DUF4150 PF13665.6 CAV26830.1 - 9.5e-19 67.6 1.9 1.6e-18 66.8 1.2 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF4150) CarboxypepD_reg PF13620.6 CAV26830.1 - 0.02 15.2 2.3 0.047 14.0 0.3 2.4 1 1 1 2 2 2 0 Carboxypeptidase regulatory-like domain CopC PF04234.12 CAV26830.1 - 0.03 15.3 0.0 0.075 14.1 0.0 1.7 1 1 1 2 2 2 0 CopC domain NHS PF15273.6 CAV26830.1 - 0.076 12.1 0.0 0.096 11.8 0.0 1.0 1 0 0 1 1 1 0 NHS-like SpaA PF17802.1 CAV26830.1 - 0.11 12.8 3.3 0.23 11.8 0.2 2.4 2 1 0 2 2 2 0 Prealbumin-like fold domain AHH PF14412.6 CAV26833.1 - 1.6e-13 50.7 0.6 3.1e-13 49.8 0.4 1.5 1 1 0 1 1 1 1 A nuclease family of the HNH/ENDO VII superfamily with conserved AHH DUF4150 PF13665.6 CAV26834.1 - 2.6e-18 66.1 1.4 6.1e-18 65.0 1.4 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4150) CopC PF04234.12 CAV26834.1 - 0.11 13.5 0.0 0.3 12.2 0.0 1.7 1 0 0 1 1 1 0 CopC domain CarboxypepD_reg PF13620.6 CAV26834.1 - 0.18 12.1 1.6 0.56 10.5 0.5 2.3 1 1 1 2 2 2 0 Carboxypeptidase regulatory-like domain Rep-A_N PF04057.12 CAV26836.1 - 0.12 12.4 0.1 0.2 11.7 0.1 1.3 1 0 0 1 1 1 0 Replication factor-A protein 1, N-terminal domain AHH PF14412.6 CAV26837.1 - 6.3e-15 55.2 0.2 4.1e-14 52.6 0.2 2.1 1 1 0 1 1 1 1 A nuclease family of the HNH/ENDO VII superfamily with conserved AHH DUF4150 PF13665.6 CAV26838.1 - 5.7e-17 61.8 0.8 1.6e-16 60.4 0.8 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF4150) CarboxypepD_reg PF13620.6 CAV26838.1 - 0.083 13.2 1.0 0.2 12.0 0.4 1.9 1 1 1 2 2 2 0 Carboxypeptidase regulatory-like domain CopC PF04234.12 CAV26838.1 - 0.1 13.6 0.0 0.28 12.3 0.0 1.7 1 0 0 1 1 1 0 CopC domain AHH PF14412.6 CAV26841.1 - 1.8e-15 57.0 0.2 3.1e-15 56.2 0.2 1.3 1 0 0 1 1 1 1 A nuclease family of the HNH/ENDO VII superfamily with conserved AHH Tyr-DNA_phospho PF06087.12 CAV26841.1 - 0.00095 18.2 0.0 0.0011 18.0 0.0 1.1 1 0 0 1 1 1 1 Tyrosyl-DNA phosphodiesterase DUF4150 PF13665.6 CAV26842.1 - 1.1e-18 67.3 1.0 2.7e-18 66.1 1.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4150) Abhydrolase_2 PF02230.16 CAV26842.1 - 0.064 13.1 0.1 0.5 10.1 0.0 2.1 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase CopC PF04234.12 CAV26842.1 - 0.11 13.6 0.0 0.32 12.1 0.0 1.8 1 0 0 1 1 1 0 CopC domain CarboxypepD_reg PF13620.6 CAV26842.1 - 0.19 12.0 2.1 0.29 11.4 0.3 2.2 2 1 1 3 3 3 0 Carboxypeptidase regulatory-like domain Feld-I_B PF09252.10 CAV26844.1 - 0.16 11.9 0.2 19 5.3 0.0 3.2 3 1 2 5 5 5 0 Allergen Fel d I-B chain AHH PF14412.6 CAV26845.1 - 2.3e-19 69.5 0.0 6.7e-19 68.0 0.0 1.7 2 0 0 2 2 2 1 A nuclease family of the HNH/ENDO VII superfamily with conserved AHH AHH PF14412.6 CAV26849.1 - 1.2e-09 38.2 0.1 2.7e-09 37.1 0.1 1.6 1 0 0 1 1 1 1 A nuclease family of the HNH/ENDO VII superfamily with conserved AHH DUF4150 PF13665.6 CAV26850.1 - 8.5e-35 119.2 2.6 1.9e-34 118.1 2.6 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4150) CopC PF04234.12 CAV26850.1 - 0.12 13.4 0.0 0.34 12.0 0.0 1.8 1 0 0 1 1 1 0 CopC domain DotU PF09850.9 CAV26851.1 - 1e-49 169.0 0.0 1.3e-49 168.7 0.0 1.0 1 0 0 1 1 1 1 Type VI secretion system protein DotU T6SS_VasE PF05936.12 CAV26852.1 - 1.6e-139 465.3 0.0 1.8e-139 465.2 0.0 1.0 1 0 0 1 1 1 1 Bacterial Type VI secretion, VC_A0110, EvfL, ImpJ, VasE T6SS-SciN PF12790.7 CAV26853.1 - 7.2e-31 106.4 0.0 8.6e-31 106.2 0.0 1.1 1 0 0 1 1 1 1 Type VI secretion lipoprotein, VasD, EvfM, TssJ, VC_A0113 Sortase PF04203.13 CAV26853.1 - 0.13 12.1 0.0 0.14 11.9 0.0 1.2 1 0 0 1 1 1 0 Sortase domain FHA PF00498.26 CAV26854.1 - 3.2e-15 56.2 0.1 8.2e-15 54.9 0.1 1.8 1 0 0 1 1 1 1 FHA domain Rep_2 PF01719.17 CAV26854.1 - 0.0029 17.4 1.7 0.22 11.3 0.2 2.3 2 0 0 2 2 2 2 Plasmid replication protein OMP_b-brl PF13505.6 CAV26855.1 - 0.00027 21.1 0.2 0.00034 20.8 0.2 1.2 1 0 0 1 1 1 1 Outer membrane protein beta-barrel domain ImpA_N PF06812.12 CAV26856.1 - 1.2e-24 86.6 0.0 2.7e-24 85.5 0.0 1.6 1 0 0 1 1 1 1 ImpA, N-terminal, type VI secretion system ImcF-related_N PF14331.6 CAV26857.1 - 1.2e-48 165.8 0.0 2e-48 165.0 0.0 1.4 1 0 0 1 1 1 1 ImcF-related N-terminal domain IcmF-related PF06761.12 CAV26857.1 - 2.9e-45 155.1 1.0 5.8e-45 154.1 1.0 1.5 1 0 0 1 1 1 1 Intracellular multiplication and human macrophage-killing IcmF_C PF06744.12 CAV26857.1 - 4.9e-45 153.6 0.0 8.3e-45 152.9 0.0 1.4 1 0 0 1 1 1 1 Type VI secretion protein IcmF C-terminal Spore_III_AB PF09548.10 CAV26857.1 - 0.046 13.8 0.2 6.6 6.8 0.0 3.4 2 1 1 3 3 3 0 Stage III sporulation protein AB (spore_III_AB) HTH_AsnC-type PF13404.6 CAV26858.1 - 4.8e-14 51.9 1.0 7.4e-14 51.3 1.0 1.3 1 0 0 1 1 1 1 AsnC-type helix-turn-helix domain HTH_24 PF13412.6 CAV26858.1 - 2.1e-13 49.6 3.2 3.6e-13 48.9 3.2 1.4 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding AsnC_trans_reg PF01037.21 CAV26858.1 - 5.6e-11 42.2 0.0 1.1e-10 41.3 0.0 1.5 1 0 0 1 1 1 1 Lrp/AsnC ligand binding domain TrmB PF01978.19 CAV26858.1 - 1.7e-05 24.6 0.1 3.5e-05 23.6 0.1 1.5 2 0 0 2 2 1 1 Sugar-specific transcriptional regulator TrmB MarR_2 PF12802.7 CAV26858.1 - 0.00012 21.9 0.1 0.00019 21.2 0.1 1.4 1 0 0 1 1 1 1 MarR family NapD PF03927.13 CAV26858.1 - 0.00033 20.6 0.0 0.00078 19.5 0.0 1.6 2 0 0 2 2 2 1 NapD protein HTH_11 PF08279.12 CAV26858.1 - 0.00084 19.2 0.3 0.0015 18.5 0.3 1.4 1 0 0 1 1 1 1 HTH domain MarR PF01047.22 CAV26858.1 - 0.00094 19.1 0.1 0.0023 17.8 0.1 1.6 1 0 0 1 1 1 1 MarR family HTH_36 PF13730.6 CAV26858.1 - 0.0029 17.5 0.3 0.051 13.5 0.1 2.2 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_20 PF12840.7 CAV26858.1 - 0.004 17.2 0.0 0.034 14.2 0.0 2.1 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_9 PF08221.11 CAV26858.1 - 0.0058 16.7 0.0 0.01 15.9 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase III subunit RPC82 helix-turn-helix domain HTH_5 PF01022.20 CAV26858.1 - 0.006 16.4 0.1 0.012 15.4 0.1 1.5 1 0 0 1 1 1 1 Bacterial regulatory protein, arsR family HTH_50 PF18024.1 CAV26858.1 - 0.0084 15.7 0.0 0.021 14.4 0.0 1.7 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_28 PF13518.6 CAV26858.1 - 0.0088 16.1 0.1 0.015 15.5 0.1 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_Crp_2 PF13545.6 CAV26858.1 - 0.015 15.3 0.3 0.051 13.6 0.3 2.0 2 1 0 2 2 2 0 Crp-like helix-turn-helix domain RuvB_C PF05491.13 CAV26858.1 - 0.016 15.1 0.1 0.031 14.1 0.1 1.5 1 0 0 1 1 1 0 RuvB C-terminal winged helix domain HTH_IclR PF09339.10 CAV26858.1 - 0.041 13.7 0.0 0.08 12.8 0.0 1.5 1 0 0 1 1 1 0 IclR helix-turn-helix domain Cdc6_C PF09079.11 CAV26858.1 - 0.043 13.8 0.3 0.7 9.9 0.1 2.5 1 1 0 2 2 2 0 CDC6, C terminal winged helix domain LexA_DNA_bind PF01726.16 CAV26858.1 - 0.046 13.5 0.1 0.085 12.6 0.1 1.4 1 0 0 1 1 1 0 LexA DNA binding domain GYD PF08734.11 CAV26858.1 - 0.066 13.2 0.0 0.11 12.5 0.0 1.5 1 0 0 1 1 1 0 GYD domain GntR PF00392.21 CAV26858.1 - 0.066 12.9 0.2 0.16 11.6 0.2 1.6 1 0 0 1 1 1 0 Bacterial regulatory proteins, gntR family HTH_27 PF13463.6 CAV26858.1 - 0.098 13.2 0.1 0.18 12.3 0.1 1.6 1 0 0 1 1 1 0 Winged helix DNA-binding domain HTH_29 PF13551.6 CAV26858.1 - 0.1 12.6 0.1 0.21 11.6 0.1 1.5 1 1 0 1 1 1 0 Winged helix-turn helix DUF2250 PF10007.9 CAV26858.1 - 0.15 12.2 0.0 0.32 11.1 0.0 1.6 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2250) HTH_47 PF16221.5 CAV26858.1 - 0.15 11.6 0.0 0.25 10.9 0.0 1.4 1 0 0 1 1 1 0 winged helix-turn-helix T6SS_TssG PF06996.11 CAV26859.1 - 5.4e-84 281.9 0.0 6.2e-84 281.8 0.0 1.0 1 0 0 1 1 1 1 Type VI secretion, TssG T6SS_TssF PF05947.12 CAV26860.1 - 1.6e-156 522.4 0.3 1.9e-156 522.2 0.3 1.0 1 0 0 1 1 1 1 Type VI secretion system, TssF GPW_gp25 PF04965.14 CAV26861.1 - 1.8e-16 59.6 0.0 2.4e-16 59.3 0.0 1.1 1 0 0 1 1 1 1 Gene 25-like lysozyme VipB PF05943.12 CAV26862.1 - 3.3e-179 596.1 0.0 3.8e-179 595.9 0.0 1.0 1 0 0 1 1 1 1 Type VI secretion protein, EvpB/VC_A0108, tail sheath T6SS_VipA PF05591.12 CAV26863.1 - 2.6e-57 193.0 0.2 2.9e-57 192.8 0.2 1.0 1 0 0 1 1 1 1 Type VI secretion system, VipA, VC_A0107 or Hcp2 T6SS_VasJ PF16989.5 CAV26864.1 - 5.7e-71 239.0 0.0 1.2e-70 237.9 0.0 1.6 2 0 0 2 2 2 1 Type VI secretion, EvfE, EvfF, ImpA, BimE, VC_A0119, VasJ ImpA_N PF06812.12 CAV26864.1 - 1.6e-25 89.6 0.0 6.6e-25 87.5 0.0 2.1 2 0 0 2 2 2 1 ImpA, N-terminal, type VI secretion system DUF16 PF01519.16 CAV26864.1 - 1.5 9.4 3.9 1.7 9.2 1.5 2.3 2 1 0 2 2 2 0 Protein of unknown function DUF16 Pkinase PF00069.25 CAV26865.1 - 3e-30 105.5 0.0 6.7e-30 104.3 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CAV26865.1 - 3.8e-19 69.0 0.0 7e-19 68.1 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Choline_kinase PF01633.20 CAV26865.1 - 0.003 17.2 0.2 0.023 14.3 0.0 2.3 2 0 0 2 2 2 1 Choline/ethanolamine kinase Kdo PF06293.14 CAV26865.1 - 0.0093 15.3 0.1 0.029 13.7 0.0 1.8 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 CAV26865.1 - 0.013 15.5 0.0 0.027 14.4 0.0 1.5 1 0 0 1 1 1 0 Phosphotransferase enzyme family SIR2_2 PF13289.6 CAV26865.1 - 0.023 14.8 0.4 2.2 8.4 0.0 3.0 3 1 0 3 3 3 0 SIR2-like domain Kinase-like PF14531.6 CAV26865.1 - 0.046 13.0 0.0 0.072 12.4 0.0 1.3 1 0 0 1 1 1 0 Kinase-like TORC_C PF12886.7 CAV26865.1 - 0.13 12.8 1.1 1.5 9.4 0.4 2.8 2 1 1 3 3 3 0 Transducer of regulated CREB activity, C terminus DUF1761 PF08570.10 CAV26865.1 - 0.13 12.5 0.0 0.33 11.2 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1761) KxDL PF10241.9 CAV26865.1 - 0.21 11.9 2.1 0.36 11.1 0.1 2.4 3 0 0 3 3 2 0 Uncharacterized conserved protein MscS_porin PF12795.7 CAV26865.1 - 0.23 11.0 3.0 0.22 11.0 0.8 2.1 2 0 0 2 2 2 0 Mechanosensitive ion channel porin domain Leu_zip PF15294.6 CAV26865.1 - 9.3 5.7 8.3 3.4 7.1 0.1 3.2 3 1 0 4 4 4 0 Leucine zipper DUF2202 PF09968.9 CAV26866.1 - 0.11 12.3 0.0 0.22 11.3 0.0 1.4 1 1 0 1 1 1 0 Uncharacterized protein domain (DUF2202) DUF2169 PF09937.9 CAV26867.1 - 1.8e-63 214.8 0.0 2.1e-63 214.5 0.0 1.0 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2169) Phage_GPD PF05954.11 CAV26870.1 - 9e-77 258.3 0.0 3.1e-76 256.6 0.0 1.9 2 0 0 2 2 2 1 Phage late control gene D protein (GPD) Gp5_C PF06715.12 CAV26870.1 - 0.0026 17.8 1.4 0.0026 17.8 1.4 7.2 7 0 0 7 7 7 2 Gp5 C-terminal repeat (3 copies) DUF2345 PF10106.9 CAV26870.1 - 0.057 13.3 3.0 0.058 13.3 1.0 2.0 2 1 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2345) T6SS_HCP PF05638.12 CAV26871.1 - 6.5e-29 100.9 0.0 7.7e-29 100.7 0.0 1.1 1 0 0 1 1 1 1 Type VI secretion system effector, Hcp AAA_2 PF07724.14 CAV26872.1 - 3.6e-44 150.9 0.4 2.4e-43 148.2 0.0 2.5 3 0 0 3 3 3 1 AAA domain (Cdc48 subfamily) AAA_lid_9 PF17871.1 CAV26872.1 - 6.3e-31 106.4 0.6 6.3e-31 106.4 0.6 2.8 2 1 1 3 3 3 1 AAA lid domain AAA PF00004.29 CAV26872.1 - 3.9e-22 79.1 0.7 7.1e-10 39.4 0.0 3.0 3 0 0 3 3 2 2 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 CAV26872.1 - 3.8e-14 53.4 4.2 8.6e-05 23.0 0.0 6.0 5 1 0 6 6 6 2 AAA ATPase domain AAA_5 PF07728.14 CAV26872.1 - 3.4e-13 49.8 0.1 6.8e-10 39.1 0.0 3.3 3 0 0 3 3 3 1 AAA domain (dynein-related subfamily) ClpB_D2-small PF10431.9 CAV26872.1 - 7e-12 45.2 0.1 3.2e-11 43.1 0.1 2.3 1 0 0 1 1 1 1 C-terminal, D2-small domain, of ClpB protein AAA_22 PF13401.6 CAV26872.1 - 2.2e-09 37.7 0.1 0.1 12.8 0.0 4.9 3 1 0 3 3 3 2 AAA domain Sigma54_activat PF00158.26 CAV26872.1 - 1.2e-06 28.3 0.3 2.2e-05 24.3 0.0 2.6 2 1 0 2 2 2 1 Sigma-54 interaction domain AAA_7 PF12775.7 CAV26872.1 - 2.9e-05 23.7 0.0 0.05 13.1 0.0 2.6 2 0 0 2 2 2 2 P-loop containing dynein motor region AAA_23 PF13476.6 CAV26872.1 - 0.00011 22.8 1.7 0.09 13.3 0.0 3.5 3 1 0 3 3 3 1 AAA domain NACHT PF05729.12 CAV26872.1 - 0.00011 22.2 0.0 0.2 11.6 0.0 3.2 3 0 0 3 3 2 1 NACHT domain TniB PF05621.11 CAV26872.1 - 0.00011 21.7 0.0 0.29 10.5 0.0 3.3 2 1 1 3 3 3 1 Bacterial TniB protein ATPase_2 PF01637.18 CAV26872.1 - 0.00045 20.2 0.1 8.4 6.2 0.0 4.4 5 0 0 5 5 4 0 ATPase domain predominantly from Archaea RsgA_GTPase PF03193.16 CAV26872.1 - 0.00054 19.9 0.0 0.62 9.9 0.0 2.7 2 0 0 2 2 2 1 RsgA GTPase AAA_25 PF13481.6 CAV26872.1 - 0.00061 19.4 3.3 0.71 9.4 0.0 3.5 4 1 0 4 4 4 2 AAA domain IstB_IS21 PF01695.17 CAV26872.1 - 0.00071 19.4 0.1 0.68 9.7 0.0 2.9 3 0 0 3 3 2 1 IstB-like ATP binding protein RuvB_N PF05496.12 CAV26872.1 - 0.00094 19.0 0.1 0.27 11.0 0.0 3.8 4 0 0 4 4 4 1 Holliday junction DNA helicase RuvB P-loop domain AAA_18 PF13238.6 CAV26872.1 - 0.0016 19.0 0.1 0.46 11.0 0.0 3.2 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.6 CAV26872.1 - 0.0021 18.3 0.6 0.79 9.9 0.1 3.4 3 1 0 3 3 2 1 AAA domain Zeta_toxin PF06414.12 CAV26872.1 - 0.0021 17.4 0.3 0.27 10.5 0.0 3.1 3 0 0 3 3 3 1 Zeta toxin RNA_helicase PF00910.22 CAV26872.1 - 0.0036 17.7 0.1 2.1 8.8 0.0 3.1 3 0 0 3 3 3 1 RNA helicase ResIII PF04851.15 CAV26872.1 - 0.0044 17.1 0.2 1.4 8.9 0.0 3.6 4 0 0 4 4 3 1 Type III restriction enzyme, res subunit Roc PF08477.13 CAV26872.1 - 0.0053 17.0 0.1 2.5 8.3 0.0 3.3 3 0 0 3 3 3 1 Ras of Complex, Roc, domain of DAPkinase AAA_30 PF13604.6 CAV26872.1 - 0.0059 16.4 0.4 6.9 6.3 0.1 3.5 3 1 0 3 3 3 0 AAA domain TIP49 PF06068.13 CAV26872.1 - 0.01 15.1 0.2 12 5.0 0.0 3.2 2 1 1 3 3 3 0 TIP49 P-loop domain Clp_N PF02861.20 CAV26872.1 - 0.033 14.3 0.1 0.13 12.4 0.1 2.1 1 0 0 1 1 1 0 Clp amino terminal domain, pathogenicity island component Ran-binding PF05508.11 CAV26872.1 - 0.039 12.9 2.3 0.057 12.4 0.4 2.0 1 1 1 2 2 2 0 RanGTP-binding protein AAA_24 PF13479.6 CAV26872.1 - 0.06 13.1 0.0 2.6 7.7 0.0 2.9 2 1 0 2 2 2 0 AAA domain AAA_19 PF13245.6 CAV26872.1 - 0.087 13.2 6.6 9.2 6.6 0.1 4.9 4 1 0 5 5 4 0 AAA domain TsaE PF02367.17 CAV26872.1 - 0.091 12.8 2.0 3.7 7.6 0.1 3.2 4 0 0 4 4 3 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE K-box PF01486.17 CAV26872.1 - 0.46 10.7 6.9 0.052 13.7 2.0 1.9 2 0 0 2 2 1 0 K-box region MscS_porin PF12795.7 CAV26872.1 - 1.6 8.2 16.4 0.058 12.9 6.1 2.8 3 0 0 3 3 2 0 Mechanosensitive ion channel porin domain Sigma54_activat PF00158.26 CAV26873.1 - 1.4e-68 229.9 0.0 2.2e-68 229.2 0.0 1.2 1 0 0 1 1 1 1 Sigma-54 interaction domain Sigma54_activ_2 PF14532.6 CAV26873.1 - 6.2e-21 75.0 0.0 2.3e-20 73.1 0.0 2.0 1 1 0 1 1 1 1 Sigma-54 interaction domain HTH_8 PF02954.19 CAV26873.1 - 5.3e-09 35.7 0.0 1.3e-08 34.4 0.0 1.7 1 0 0 1 1 1 1 Bacterial regulatory protein, Fis family AAA_5 PF07728.14 CAV26873.1 - 2.8e-07 30.6 0.0 4.4e-06 26.7 0.0 2.4 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) HTH_50 PF18024.1 CAV26873.1 - 3.1e-05 23.5 0.0 7.8e-05 22.2 0.0 1.7 1 0 0 1 1 1 1 Helix-turn-helix domain GAF PF01590.26 CAV26873.1 - 0.00041 21.0 0.2 0.0012 19.5 0.0 1.9 2 0 0 2 2 1 1 GAF domain GAF_3 PF13492.6 CAV26873.1 - 0.0093 16.3 0.0 0.031 14.6 0.0 2.0 1 1 0 1 1 1 1 GAF domain AAA_3 PF07726.11 CAV26873.1 - 0.043 13.7 0.0 0.09 12.6 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA PF00004.29 CAV26873.1 - 0.046 14.1 0.0 0.15 12.5 0.0 1.9 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Sipho_Gp157 PF05565.11 CAV26873.1 - 0.078 13.0 0.1 0.21 11.6 0.1 1.7 1 0 0 1 1 1 0 Siphovirus Gp157 Mg_chelatase PF01078.21 CAV26873.1 - 0.082 12.3 0.1 1.3 8.3 0.1 2.4 1 1 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_7 PF12775.7 CAV26873.1 - 0.082 12.4 0.0 0.22 11.0 0.0 1.7 1 1 1 2 2 2 0 P-loop containing dynein motor region DUF1828 PF08861.10 CAV26875.1 - 0.1 12.9 0.0 0.22 11.8 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function DUF1828 OmpA PF00691.20 CAV26876.1 - 9.2e-12 45.2 0.0 2.4e-11 43.9 0.0 1.8 1 0 0 1 1 1 1 OmpA family SGL PF08450.12 CAV26880.1 - 0.063 12.9 0.0 0.092 12.3 0.0 1.2 1 0 0 1 1 1 0 SMP-30/Gluconolactonase/LRE-like region LPAM_1 PF08139.12 CAV26881.1 - 0.32 11.6 1.4 0.68 10.5 1.4 1.6 1 0 0 1 1 1 0 Prokaryotic membrane lipoprotein lipid attachment site Pectate_lyase22 PF14583.6 CAV26883.1 - 0.015 14.0 0.1 2.5 6.7 0.0 2.2 2 0 0 2 2 2 0 Oligogalacturonate lyase Peptidase_S9_N PF02897.15 CAV26887.1 - 0.0022 16.9 0.4 0.0059 15.5 0.1 1.7 2 0 0 2 2 2 1 Prolyl oligopeptidase, N-terminal beta-propeller domain Big_10 PF17964.1 CAV26889.1 - 2e-07 31.2 27.8 0.038 14.0 0.5 6.6 6 0 0 6 6 6 4 Bacterial Ig domain Invasin_D3 PF09134.10 CAV26889.1 - 3.8e-05 23.9 45.7 0.53 10.6 3.4 8.7 7 0 0 7 7 7 5 Invasin, domain 3 TcfC PF16967.5 CAV26889.1 - 7.4e-05 22.2 6.7 27 4.3 0.1 6.4 6 0 0 6 6 6 1 E-set like domain LupA PF18242.1 CAV26889.1 - 0.059 13.0 0.0 0.26 10.9 0.0 2.1 2 0 0 2 2 2 0 Legionella ubiquitin-specific protease A domain CopC PF04234.12 CAV26889.1 - 0.75 10.9 32.5 9.3 7.4 0.1 10.0 13 0 0 13 13 13 0 CopC domain Shadoo PF14999.6 CAV26889.1 - 3.6 7.7 18.5 31 4.7 0.7 5.0 4 0 0 4 4 4 0 Shadow of prion protein, neuroprotective Peptidase_M23 PF01551.22 CAV26890.1 - 1.1e-25 89.7 0.1 2e-25 88.8 0.1 1.4 1 0 0 1 1 1 1 Peptidase family M23 Molybdopterin PF00384.22 CAV26892.1 - 3.3e-81 273.4 0.0 4.4e-81 273.0 0.0 1.1 1 0 0 1 1 1 1 Molybdopterin oxidoreductase Molydop_binding PF01568.21 CAV26892.1 - 1.6e-22 79.6 0.0 4.8e-12 45.9 0.0 2.7 2 0 0 2 2 2 2 Molydopterin dinucleotide binding domain Molybdop_Fe4S4 PF04879.16 CAV26892.1 - 4.1e-16 58.7 0.8 9.2e-16 57.6 0.8 1.5 1 0 0 1 1 1 1 Molybdopterin oxidoreductase Fe4S4 domain Pyr_redox_2 PF07992.14 CAV26893.1 - 8.1e-53 179.6 0.2 1.5e-52 178.7 0.2 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Fer2_BFD PF04324.15 CAV26893.1 - 8.8e-22 77.2 4.8 7.6e-14 51.8 2.8 2.8 2 0 0 2 2 2 2 BFD-like [2Fe-2S] binding domain NIR_SIR PF01077.22 CAV26893.1 - 1.4e-19 70.1 0.0 3.1e-19 69.0 0.0 1.6 1 0 0 1 1 1 1 Nitrite and sulphite reductase 4Fe-4S domain Pyr_redox PF00070.27 CAV26893.1 - 1.9e-18 66.8 4.4 7.1e-15 55.3 0.4 3.8 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Rubredoxin_C PF18267.1 CAV26893.1 - 1.2e-12 47.6 0.6 6.5e-12 45.2 0.6 2.3 1 0 0 1 1 1 1 Rubredoxin NAD+ reductase C-terminal domain Pyr_redox_3 PF13738.6 CAV26893.1 - 5.4e-11 42.3 1.1 1e-10 41.4 0.1 2.1 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NIR_SIR_ferr PF03460.17 CAV26893.1 - 7.4e-10 38.5 0.0 1.6e-09 37.4 0.0 1.6 1 0 0 1 1 1 1 Nitrite/Sulfite reductase ferredoxin-like half domain FAD_binding_2 PF00890.24 CAV26893.1 - 2e-06 27.2 1.0 0.0081 15.3 0.0 2.3 2 0 0 2 2 2 2 FAD binding domain HI0933_like PF03486.14 CAV26893.1 - 2.4e-05 23.2 0.5 0.63 8.7 0.0 3.2 2 1 1 3 3 3 2 HI0933-like protein GIDA PF01134.22 CAV26893.1 - 0.00049 19.3 5.0 0.059 12.4 0.3 3.8 5 0 0 5 5 5 1 Glucose inhibited division protein A NAD_binding_9 PF13454.6 CAV26893.1 - 0.0047 16.9 0.2 5.9 6.9 0.0 3.4 3 1 1 4 4 4 1 FAD-NAD(P)-binding DAO PF01266.24 CAV26893.1 - 0.018 14.7 0.8 2.8 7.4 0.0 3.2 2 1 0 3 3 3 0 FAD dependent oxidoreductase AlaDh_PNT_C PF01262.21 CAV26893.1 - 0.022 14.0 2.0 0.069 12.4 0.2 2.4 3 0 0 3 3 3 0 Alanine dehydrogenase/PNT, C-terminal domain K_oxygenase PF13434.6 CAV26893.1 - 0.022 13.9 0.0 0.29 10.2 0.0 2.1 1 1 1 2 2 2 0 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_7 PF13241.6 CAV26893.1 - 0.15 12.6 0.1 6.8 7.2 0.0 2.7 2 0 0 2 2 2 0 Putative NAD(P)-binding Rieske_2 PF13806.6 CAV26894.1 - 5.2e-37 125.9 0.0 5.8e-37 125.8 0.0 1.0 1 0 0 1 1 1 1 Rieske-like [2Fe-2S] domain MFS_1 PF07690.16 CAV26895.1 - 2.2e-35 122.2 51.4 2.7e-21 75.9 24.1 2.1 2 0 0 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 CAV26895.1 - 3.4e-09 36.1 24.4 2.9e-05 23.1 6.0 2.5 2 1 0 2 2 2 2 Sugar (and other) transporter MFS_1_like PF12832.7 CAV26895.1 - 0.00073 18.5 1.6 0.00073 18.5 1.6 3.5 4 0 0 4 4 4 2 MFS_1 like family IncE PF17627.2 CAV26895.1 - 0.074 13.1 0.2 0.22 11.5 0.2 1.7 1 0 0 1 1 1 0 Inclusion membrane protein E Pkinase PF00069.25 CAV26896.1 - 3e-37 128.4 0.0 5e-37 127.7 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CAV26896.1 - 1.3e-27 96.8 0.0 2.1e-27 96.1 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase PP2C_2 PF13672.6 CAV26896.1 - 9e-16 58.1 0.1 1.5e-15 57.5 0.1 1.3 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C PF00481.21 CAV26896.1 - 4.1e-11 43.0 0.5 2.9e-08 33.6 0.5 2.3 1 1 1 2 2 2 2 Protein phosphatase 2C APH PF01636.23 CAV26896.1 - 4.8e-07 29.9 0.2 0.0098 15.8 0.0 2.3 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.14 CAV26896.1 - 4.7e-05 22.8 0.0 9.9e-05 21.8 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 CAV26896.1 - 0.00039 19.8 0.0 0.2 11.0 0.0 2.3 2 0 0 2 2 2 2 Kinase-like SpoIIE PF07228.12 CAV26896.1 - 0.00073 19.5 0.0 0.0013 18.7 0.0 1.4 1 0 0 1 1 1 1 Stage II sporulation protein E (SpoIIE) RIO1 PF01163.22 CAV26896.1 - 0.0008 19.0 0.0 0.0045 16.6 0.0 2.1 2 0 0 2 2 2 1 RIO1 family DUF2944 PF11161.8 CAV26896.1 - 0.0077 16.1 0.1 0.017 15.0 0.1 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF2946) WaaY PF06176.11 CAV26896.1 - 0.029 14.0 0.0 0.05 13.2 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide core biosynthesis protein (WaaY) Seadorna_VP7 PF07387.11 CAV26896.1 - 0.078 12.0 0.0 0.13 11.3 0.0 1.3 1 0 0 1 1 1 0 Seadornavirus VP7 Choline_sulf_C PF12411.8 CAV26896.1 - 0.22 11.4 0.9 0.41 10.5 0.1 1.9 2 0 0 2 2 2 0 Choline sulfatase enzyme C terminal LacI PF00356.21 CAV26897.1 - 3.4e-18 65.1 0.4 8.4e-18 63.9 0.4 1.7 1 0 0 1 1 1 1 Bacterial regulatory proteins, lacI family Peripla_BP_1 PF00532.21 CAV26897.1 - 1.1e-12 48.0 0.0 1.5e-12 47.6 0.0 1.2 1 0 0 1 1 1 1 Periplasmic binding proteins and sugar binding domain of LacI family Peripla_BP_4 PF13407.6 CAV26897.1 - 4.4e-09 36.3 0.0 6.2e-09 35.8 0.0 1.2 1 0 0 1 1 1 1 Periplasmic binding protein domain HTH_3 PF01381.22 CAV26897.1 - 0.0055 16.7 0.0 0.012 15.6 0.0 1.6 1 0 0 1 1 1 1 Helix-turn-helix HTH_10 PF04967.12 CAV26897.1 - 0.038 13.8 0.0 0.089 12.6 0.0 1.6 1 0 0 1 1 1 0 HTH DNA binding domain Glyco_tran_WecB PF03808.13 CAV26897.1 - 0.16 11.9 0.0 0.49 10.3 0.0 1.8 2 0 0 2 2 2 0 Glycosyl transferase WecB/TagA/CpsF family PTS_EIIA_2 PF00359.22 CAV26898.1 - 1.7e-39 135.0 0.0 4.3e-33 114.2 0.0 2.3 2 0 0 2 2 2 2 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 PTS-HPr PF00381.19 CAV26898.1 - 1.4e-25 89.4 0.7 4.6e-25 87.7 0.7 1.9 1 0 0 1 1 1 1 PTS HPr component phosphorylation site PfkB PF00294.24 CAV26899.1 - 4.1e-49 167.5 0.1 5.1e-49 167.2 0.1 1.0 1 0 0 1 1 1 1 pfkB family carbohydrate kinase Phos_pyr_kin PF08543.12 CAV26899.1 - 1.3e-06 28.0 0.0 2.1e-06 27.3 0.0 1.3 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase Carb_kinase PF01256.17 CAV26899.1 - 0.0053 16.3 0.2 0.045 13.2 0.0 1.9 1 1 1 2 2 2 1 Carbohydrate kinase PTS_IIB PF02302.17 CAV26900.1 - 2e-30 105.3 6.0 3.3e-16 59.8 0.5 2.7 2 0 0 2 2 2 2 PTS system, Lactose/Cellobiose specific IIB subunit PTS_EIIC PF02378.18 CAV26900.1 - 1.1e-15 57.5 35.6 1.1e-15 57.5 35.6 2.8 2 1 0 2 2 2 1 Phosphotransferase system, EIIC DUF2228 PF10228.9 CAV26900.1 - 0.44 10.2 1.3 0.81 9.4 1.3 1.3 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2228) HTH_AraC PF00165.23 CAV26901.1 - 7.1e-16 57.9 0.0 1e-07 31.8 0.0 2.8 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family HTH_18 PF12833.7 CAV26901.1 - 1.2e-15 57.5 0.1 3.1e-15 56.2 0.0 1.8 2 0 0 2 2 2 1 Helix-turn-helix domain SdiA-regulated PF06977.11 CAV26901.1 - 0.14 11.4 0.0 0.23 10.7 0.0 1.2 1 0 0 1 1 1 0 SdiA-regulated ACR_tran PF00873.19 CAV26903.1 - 1.6e-145 486.3 16.4 2.7e-91 306.8 9.6 1.9 2 0 0 2 2 2 2 AcrB/AcrD/AcrF family MMPL PF03176.15 CAV26903.1 - 3.3e-06 26.3 1.6 3.3e-06 26.3 1.6 2.7 3 0 0 3 3 3 1 MMPL family SecD_SecF PF02355.16 CAV26903.1 - 0.0002 20.8 24.1 0.0023 17.4 10.0 2.9 2 1 0 2 2 2 2 Protein export membrane protein Plug PF07715.15 CAV26903.1 - 0.062 13.9 3.3 0.21 12.2 2.7 2.3 1 1 0 1 1 1 0 TonB-dependent Receptor Plug Domain HMA PF00403.26 CAV26903.1 - 0.12 12.8 0.4 21 5.6 0.1 3.4 3 0 0 3 3 3 0 Heavy-metal-associated domain HlyD_3 PF13437.6 CAV26904.1 - 5.4e-12 46.4 1.4 1.8e-09 38.2 0.3 2.6 2 0 0 2 2 2 2 HlyD family secretion protein HlyD_D23 PF16576.5 CAV26904.1 - 1.1e-09 37.8 5.7 1.2e-09 37.7 4.0 1.7 1 1 1 2 2 2 1 Barrel-sandwich domain of CusB or HlyD membrane-fusion Biotin_lipoyl_2 PF13533.6 CAV26904.1 - 6.4e-05 22.7 2.0 0.00033 20.4 2.0 2.4 1 1 0 1 1 1 1 Biotin-lipoyl like PapD_C PF02753.17 CAV26904.1 - 0.037 14.4 0.9 2.1 8.7 0.1 3.3 3 0 0 3 3 3 0 Pili assembly chaperone PapD, C-terminal domain CDRT4 PF15213.6 CAV26904.1 - 0.079 13.6 1.1 0.49 11.0 0.0 2.4 2 0 0 2 2 2 0 CMT1A duplicated region transcript 4 protein ATP-synt_DE PF00401.20 CAV26904.1 - 0.11 12.8 2.0 23 5.4 0.0 2.7 2 0 0 2 2 2 0 ATP synthase, Delta/Epsilon chain, long alpha-helix domain Tricorn_PDZ PF14685.6 CAV26904.1 - 0.13 12.3 0.5 4.1 7.4 0.1 2.7 2 0 0 2 2 2 0 Tricorn protease PDZ domain ABC_membrane_3 PF13748.6 CAV26905.1 - 7.9e-91 303.5 10.4 7.9e-91 303.5 10.4 1.4 2 0 0 2 2 2 1 ABC transporter transmembrane region ABC_membrane PF00664.23 CAV26905.1 - 1.6e-06 28.0 18.3 0.0013 18.4 12.3 3.0 1 1 1 2 2 2 2 ABC transporter transmembrane region DUF4461 PF14688.6 CAV26906.1 - 0.0025 17.7 0.3 0.0031 17.3 0.3 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4461) ATP-synt_ab_C PF00306.27 CAV26906.1 - 0.0025 18.1 0.6 0.0041 17.5 0.6 1.3 1 0 0 1 1 1 1 ATP synthase alpha/beta chain, C terminal domain MotA_ExbB PF01618.16 CAV26906.1 - 0.16 11.8 0.2 0.31 10.8 0.2 1.5 1 0 0 1 1 1 0 MotA/TolQ/ExbB proton channel family FA_hydroxylase PF04116.13 CAV26907.1 - 5.2e-27 94.8 9.9 5.2e-27 94.8 9.9 2.1 2 1 0 2 2 2 1 Fatty acid hydroxylase superfamily TadE PF07811.12 CAV26907.1 - 3.1 8.2 8.4 9.5 6.6 0.2 2.7 2 0 0 2 2 2 0 TadE-like protein Response_reg PF00072.24 CAV26908.1 - 1.1e-27 96.5 0.1 1.5e-27 95.9 0.1 1.2 1 0 0 1 1 1 1 Response regulator receiver domain Trans_reg_C PF00486.28 CAV26908.1 - 1.4e-10 41.1 0.0 2.8e-10 40.1 0.0 1.5 1 0 0 1 1 1 1 Transcriptional regulatory protein, C terminal SBP_bac_3 PF00497.20 CAV26908.1 - 0.026 13.9 0.0 0.046 13.1 0.0 1.3 1 0 0 1 1 1 0 Bacterial extracellular solute-binding proteins, family 3 Fibroin_P25 PF07294.11 CAV26908.1 - 0.21 11.6 0.0 0.3 11.1 0.0 1.2 1 0 0 1 1 1 0 Fibroin P25 HisKA PF00512.25 CAV26909.1 - 2e-09 37.3 0.1 5e-09 36.1 0.1 1.7 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain HATPase_c_5 PF14501.6 CAV26909.1 - 1.5e-06 28.1 1.5 9.5e-06 25.5 1.5 2.2 1 1 0 1 1 1 1 GHKL domain HATPase_c PF02518.26 CAV26909.1 - 0.094 13.2 0.2 0.5 10.9 0.1 2.3 1 1 1 2 2 2 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase TRIQK PF15168.6 CAV26909.1 - 0.17 11.8 2.8 0.66 9.9 0.2 2.9 3 0 0 3 3 3 0 Triple QxxK/R motif-containing protein family DOPA_dioxygen PF08883.11 CAV26911.1 - 2.1e-25 89.0 0.0 2.3e-25 88.8 0.0 1.0 1 0 0 1 1 1 1 Dopa 4,5-dioxygenase family DUF3303 PF11746.8 CAV26911.1 - 0.017 15.4 0.0 0.02 15.2 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3303) GST_C_2 PF13410.6 CAV26912.1 - 1.6e-09 37.6 0.7 3.1e-09 36.7 0.1 1.8 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 CAV26912.1 - 2.1e-08 34.3 0.3 1.3e-07 31.7 0.1 2.1 1 1 1 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 CAV26912.1 - 1e-06 29.0 0.0 2e-06 28.1 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 CAV26912.1 - 3.5e-05 23.9 0.1 6.2e-05 23.1 0.1 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.6 CAV26912.1 - 3.5e-05 24.0 0.0 0.00013 22.2 0.0 2.0 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 CAV26912.1 - 0.0014 19.0 0.0 0.003 17.9 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain Glutaredoxin2_C PF04399.13 CAV26912.1 - 0.13 12.1 0.0 0.2 11.5 0.0 1.3 1 0 0 1 1 1 0 Glutaredoxin 2, C terminal domain HNH PF01844.23 CAV26914.1 - 4.5e-11 42.7 8.0 6.7e-11 42.2 8.0 1.3 1 0 0 1 1 1 1 HNH endonuclease Ima1_N PF09779.9 CAV26914.1 - 0.0043 17.9 1.0 0.68 10.8 0.1 2.1 2 0 0 2 2 2 2 Ima1 N-terminal domain DUF3268 PF11672.8 CAV26914.1 - 0.038 14.3 2.9 0.2 12.0 0.2 2.0 1 1 0 2 2 2 0 zinc-finger-containing domain Endonuclease_7 PF02945.15 CAV26914.1 - 1.2 9.1 8.8 2.1 8.3 8.8 1.6 1 1 0 1 1 1 0 Recombination endonuclease VII DUF1201 PF06716.11 CAV26915.1 - 0.057 13.5 0.1 0.057 13.5 0.1 2.5 2 1 1 3 3 3 0 Protein of unknown function (DUF1201) DUF92 PF01940.16 CAV26915.1 - 1.7 8.0 6.9 0.39 10.1 2.6 1.8 1 1 1 2 2 2 0 Integral membrane protein DUF92 MFS_1 PF07690.16 CAV26916.1 - 2.4e-41 141.9 54.5 2.5e-30 105.6 28.7 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily VRR_NUC PF08774.11 CAV26917.1 - 1.8e-22 79.4 0.0 5.6e-22 77.9 0.0 1.9 1 0 0 1 1 1 1 VRR-NUC domain FANC_SAP PF18081.1 CAV26917.1 - 0.00012 22.1 0.1 0.00039 20.5 0.1 1.8 1 0 0 1 1 1 1 Fanconi anemia-associated nuclease SAP domain Nod1 PF17114.5 CAV26917.1 - 0.19 11.9 2.1 5.4 7.2 0.0 3.4 3 0 0 3 3 3 0 Gef2-related medial cortical node protein Nod1 CTI PF06934.11 CAV26918.1 - 1.2e-289 962.8 4.3 1.3e-289 962.6 4.3 1.0 1 0 0 1 1 1 1 Fatty acid cis/trans isomerase (CTI) HATPase_c PF02518.26 CAV26919.1 - 2.5e-29 102.0 0.6 7.8e-29 100.4 0.6 1.9 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 CAV26919.1 - 1.3e-18 66.8 1.2 1.1e-17 63.8 0.0 3.4 3 0 0 3 3 3 1 His Kinase A (phospho-acceptor) domain Response_reg PF00072.24 CAV26919.1 - 3e-18 66.0 0.5 1.2e-17 64.0 0.0 2.5 2 0 0 2 2 2 1 Response regulator receiver domain Hpt PF01627.23 CAV26919.1 - 2.6e-11 43.6 0.8 2.6e-11 43.6 0.8 4.2 5 0 0 5 5 5 1 Hpt domain 4HB_MCP_1 PF12729.7 CAV26919.1 - 2.4e-05 24.0 14.5 4.9e-05 22.9 0.2 3.7 1 1 1 3 3 3 2 Four helix bundle sensory module for signal transduction HAMP PF00672.25 CAV26919.1 - 0.00078 19.8 0.0 0.0038 17.6 0.0 2.3 1 0 0 1 1 1 1 HAMP domain HATPase_c_5 PF14501.6 CAV26919.1 - 0.0019 18.1 0.1 0.02 14.8 0.0 2.8 2 0 0 2 2 2 1 GHKL domain Vpu PF00558.19 CAV26919.1 - 5 7.0 7.0 16 5.4 5.5 2.7 1 1 1 2 2 2 0 Vpu protein SAE2 PF08573.10 CAV26919.1 - 5 8.3 5.4 5.8 8.1 2.9 2.4 2 0 0 2 2 2 0 DNA repair protein endonuclease SAE2/CtIP C-terminus Peripla_BP_1 PF00532.21 CAV26920.1 - 2.2e-31 109.3 0.0 2.7e-31 109.0 0.0 1.0 1 0 0 1 1 1 1 Periplasmic binding proteins and sugar binding domain of LacI family Peripla_BP_4 PF13407.6 CAV26920.1 - 1.3e-14 54.4 0.0 1.5e-14 54.2 0.0 1.1 1 0 0 1 1 1 1 Periplasmic binding protein domain MGS PF02142.22 CAV26921.1 - 6.4e-19 67.9 0.0 9.1e-19 67.5 0.0 1.2 1 0 0 1 1 1 1 MGS-like domain MCPsignal PF00015.21 CAV26922.1 - 7e-34 117.1 25.1 9.2e-33 113.5 13.0 2.7 1 1 2 3 3 3 2 Methyl-accepting chemotaxis protein (MCP) signalling domain PAS_3 PF08447.12 CAV26922.1 - 1.1e-12 48.0 0.1 3e-12 46.7 0.1 1.8 1 0 0 1 1 1 1 PAS fold PAS PF00989.25 CAV26922.1 - 2.8e-11 43.4 0.0 1.5e-10 41.1 0.0 2.2 2 0 0 2 2 2 1 PAS fold PAS_9 PF13426.7 CAV26922.1 - 4e-10 39.9 0.0 1.6e-09 38.0 0.0 2.0 2 0 0 2 2 2 1 PAS domain PAS_4 PF08448.10 CAV26922.1 - 0.00088 19.5 0.0 0.0051 17.0 0.0 2.3 2 0 0 2 2 1 1 PAS fold DUF948 PF06103.11 CAV26922.1 - 0.0018 18.5 24.0 0.15 12.3 0.8 4.9 2 2 2 4 4 4 2 Bacterial protein of unknown function (DUF948) Tox-GHH PF15636.6 CAV26922.1 - 0.014 15.3 1.4 0.69 9.9 0.0 3.1 3 0 0 3 3 3 0 GHH signature containing HNH/Endo VII superfamily nuclease toxin PAS_8 PF13188.7 CAV26922.1 - 0.034 14.2 0.0 0.1 12.7 0.0 1.8 1 0 0 1 1 1 0 PAS domain MerR-DNA-bind PF09278.11 CAV26922.1 - 0.07 13.7 0.1 0.07 13.7 0.1 2.9 3 1 0 3 3 2 0 MerR, DNA binding UPF0715 PF17094.5 CAV26922.1 - 0.079 13.5 0.1 0.13 12.9 0.1 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0715) Katanin_con80 PF13925.6 CAV26922.1 - 0.2 11.6 13.0 0.083 12.9 0.8 3.7 3 1 1 4 4 3 0 con80 domain of Katanin DUF725 PF05267.12 CAV26922.1 - 0.27 11.2 13.9 0.67 10.0 4.1 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF725) FH2 PF02181.23 CAV26922.1 - 0.45 9.6 12.6 0.7 9.0 1.8 2.2 2 0 0 2 2 2 0 Formin Homology 2 Domain KxDL PF10241.9 CAV26922.1 - 0.6 10.4 12.7 0.058 13.7 2.6 3.4 2 2 0 2 2 2 0 Uncharacterized conserved protein Lebercilin PF15619.6 CAV26922.1 - 1.2 8.7 23.1 0.13 11.9 7.2 3.1 2 1 0 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease FUSC PF04632.12 CAV26922.1 - 1.6 7.2 14.4 0.41 9.1 1.4 2.2 1 1 0 2 2 2 0 Fusaric acid resistance protein family eRF1_3 PF03465.15 CAV26922.1 - 3.8 8.0 6.3 2.6 8.6 0.8 2.6 2 0 0 2 2 2 0 eRF1 domain 3 Syntaxin-6_N PF09177.11 CAV26922.1 - 5.8 7.5 22.9 9.5 6.9 5.9 4.7 3 2 0 3 3 3 0 Syntaxin 6, N-terminal Fez1 PF06818.15 CAV26922.1 - 6.2 7.2 19.3 2.8 8.4 3.5 2.3 2 0 0 2 2 2 0 Fez1 Goodbye PF17109.5 CAV26922.1 - 6.8 7.2 8.9 5.6 7.4 0.5 3.6 2 2 1 3 3 3 0 fungal STAND N-terminal Goodbye domain AsnC_trans_reg PF01037.21 CAV26923.1 - 3.9e-18 65.2 0.4 5.8e-18 64.6 0.4 1.3 1 0 0 1 1 1 1 Lrp/AsnC ligand binding domain HTH_24 PF13412.6 CAV26923.1 - 4.7e-18 64.5 0.6 7e-18 63.9 0.6 1.3 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding HTH_AsnC-type PF13404.6 CAV26923.1 - 1.1e-16 60.3 0.2 1.8e-16 59.6 0.2 1.3 1 0 0 1 1 1 1 AsnC-type helix-turn-helix domain HTH_Crp_2 PF13545.6 CAV26923.1 - 0.00077 19.4 0.0 0.0013 18.7 0.0 1.4 1 0 0 1 1 1 1 Crp-like helix-turn-helix domain HTH_11 PF08279.12 CAV26923.1 - 0.012 15.5 0.3 0.032 14.2 0.0 1.9 2 0 0 2 2 2 0 HTH domain MarR PF01047.22 CAV26923.1 - 0.013 15.4 0.0 0.028 14.3 0.0 1.5 1 0 0 1 1 1 0 MarR family HTH_28 PF13518.6 CAV26923.1 - 0.052 13.7 0.0 0.11 12.7 0.0 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain MarR_2 PF12802.7 CAV26923.1 - 0.061 13.2 0.0 0.1 12.5 0.0 1.4 1 0 0 1 1 1 0 MarR family Phage_rep_O PF04492.13 CAV26923.1 - 0.066 13.8 0.0 0.18 12.4 0.0 1.7 2 0 0 2 2 2 0 Bacteriophage replication protein O Rrf2 PF02082.20 CAV26923.1 - 0.11 12.8 0.0 0.32 11.4 0.0 1.7 2 0 0 2 2 2 0 Transcriptional regulator Gate PF07670.14 CAV26924.1 - 0.00017 21.8 16.8 0.023 15.0 4.2 3.0 1 1 2 3 3 3 2 Nucleoside recognition DUF3742 PF12553.8 CAV26924.1 - 0.43 10.7 0.1 0.43 10.7 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3742) BURP PF03181.15 CAV26927.1 - 0.013 15.1 0.4 0.014 15.0 0.4 1.1 1 0 0 1 1 1 0 BURP domain NEMP PF10225.9 CAV26927.1 - 0.16 11.6 0.4 0.18 11.5 0.4 1.1 1 0 0 1 1 1 0 NEMP family Peptidase_M6 PF05547.11 CAV26928.1 - 5.1e-279 927.2 15.0 6.9e-279 926.7 15.0 1.1 1 0 0 1 1 1 1 Immune inhibitor A peptidase M6 PKD PF00801.20 CAV26928.1 - 1.5e-19 69.6 3.8 1.8e-09 37.3 2.3 2.8 2 0 0 2 2 2 2 PKD domain BiPBP_C PF06832.12 CAV26928.1 - 0.0021 18.1 0.0 1.2 9.3 0.0 2.8 2 0 0 2 2 2 2 Penicillin-Binding Protein C-terminus Family Peptidase_M7 PF02031.16 CAV26928.1 - 0.0056 16.8 0.2 0.016 15.4 0.2 1.7 1 0 0 1 1 1 1 Streptomyces extracellular neutral proteinase (M7) family SLT_2 PF13406.6 CAV26928.1 - 0.034 13.4 1.0 0.66 9.1 0.0 2.2 2 0 0 2 2 2 0 Transglycosylase SLT domain PapD_C PF02753.17 CAV26928.1 - 0.049 14.0 0.3 9.1 6.7 0.0 3.3 3 0 0 3 3 3 0 Pili assembly chaperone PapD, C-terminal domain TORC_C PF12886.7 CAV26928.1 - 0.11 13.0 0.1 17 6.1 0.0 2.8 2 0 0 2 2 2 0 Transducer of regulated CREB activity, C terminus PKD_3 PF16820.5 CAV26928.1 - 0.14 11.9 0.5 2.4 8.0 0.4 2.6 2 0 0 2 2 2 0 PKD-like domain Cystatin PF00031.21 CAV26928.1 - 0.25 11.6 0.6 18 5.7 0.0 2.5 2 0 0 2 2 2 0 Cystatin domain MFS_1 PF07690.16 CAV26929.1 - 2.2e-27 95.9 49.5 1e-15 57.5 27.3 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 CAV26929.1 - 5.9e-07 28.7 34.3 1.5e-05 24.1 10.7 3.0 1 1 0 2 2 2 2 Sugar (and other) transporter LysR_substrate PF03466.20 CAV26931.1 - 7.6e-29 100.6 0.0 8.9e-29 100.3 0.0 1.1 1 0 0 1 1 1 1 LysR substrate binding domain HTH_1 PF00126.27 CAV26931.1 - 3.8e-17 62.0 0.0 6.8e-17 61.2 0.0 1.4 1 0 0 1 1 1 1 Bacterial regulatory helix-turn-helix protein, lysR family HTH_30 PF13556.6 CAV26931.1 - 0.0012 18.6 0.0 0.0024 17.6 0.0 1.5 1 0 0 1 1 1 1 PucR C-terminal helix-turn-helix domain HTH_5 PF01022.20 CAV26931.1 - 0.0018 18.1 0.0 0.005 16.7 0.0 1.7 1 0 0 1 1 1 1 Bacterial regulatory protein, arsR family HTH_24 PF13412.6 CAV26931.1 - 0.011 15.2 0.0 0.028 14.0 0.0 1.7 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding SBP_bac_3 PF00497.20 CAV26933.1 - 3.2e-38 131.4 0.2 8.6e-17 61.3 0.0 4.4 3 1 0 3 3 3 3 Bacterial extracellular solute-binding proteins, family 3 HATPase_c PF02518.26 CAV26933.1 - 2.4e-27 95.7 0.4 5e-27 94.6 0.4 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 CAV26933.1 - 1.4e-24 86.5 2.7 7.2e-24 84.1 0.5 3.0 3 0 0 3 3 3 1 Response regulator receiver domain HisKA PF00512.25 CAV26933.1 - 6.1e-17 61.4 0.4 5.5e-16 58.4 0.0 2.9 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain Hpt PF01627.23 CAV26933.1 - 2.2e-06 27.8 0.3 8.4e-06 26.0 0.3 2.1 1 0 0 1 1 1 1 Hpt domain PAS_9 PF13426.7 CAV26933.1 - 0.0008 19.6 0.0 0.0033 17.6 0.0 2.2 1 1 0 1 1 1 1 PAS domain PAS_8 PF13188.7 CAV26933.1 - 0.0012 18.8 0.0 0.011 15.8 0.0 2.7 2 0 0 2 2 2 1 PAS domain HATPase_c_3 PF13589.6 CAV26933.1 - 0.0014 18.5 0.0 0.003 17.4 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 CAV26934.1 - 2.5e-25 88.8 0.4 1.3e-24 86.5 0.3 2.1 2 0 0 2 2 2 1 Response regulator receiver domain HD PF01966.22 CAV26934.1 - 1.9e-18 66.8 0.0 4.7e-18 65.6 0.1 1.6 2 0 0 2 2 2 1 HD domain HD_5 PF13487.6 CAV26934.1 - 2.1e-14 53.5 0.1 5.8e-14 52.1 0.1 1.8 1 0 0 1 1 1 1 HD domain ABC_tran PF00005.27 CAV26936.1 - 6.6e-28 97.9 0.0 9e-28 97.5 0.0 1.2 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 CAV26936.1 - 3.3e-11 43.5 1.1 4.5e-05 23.4 0.1 2.2 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 CAV26936.1 - 4.4e-08 32.8 1.3 2.4e-06 27.2 1.3 2.2 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 CAV26936.1 - 8.1e-05 22.3 0.2 0.00021 20.9 0.1 1.8 1 1 0 1 1 1 1 P-loop containing region of AAA domain AAA_23 PF13476.6 CAV26936.1 - 0.00024 21.7 0.6 0.0013 19.2 0.6 2.0 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.6 CAV26936.1 - 0.00081 19.9 0.1 0.0033 18.0 0.0 1.9 1 1 1 2 2 2 1 AAA domain AAA_25 PF13481.6 CAV26936.1 - 0.0014 18.2 0.1 0.034 13.7 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.6 CAV26936.1 - 0.0034 17.1 0.0 0.0059 16.4 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_15 PF13175.6 CAV26936.1 - 0.0049 16.6 0.6 0.031 14.0 0.0 1.9 1 1 0 2 2 2 1 AAA ATPase domain AAA_27 PF13514.6 CAV26936.1 - 0.011 15.3 0.1 0.052 13.1 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.6 CAV26936.1 - 0.018 15.4 0.0 0.04 14.3 0.0 1.7 1 1 0 1 1 1 0 AAA ATPase domain AAA_22 PF13401.6 CAV26936.1 - 0.035 14.4 0.2 0.42 10.9 0.0 2.3 2 0 0 2 2 2 0 AAA domain cobW PF02492.19 CAV26936.1 - 0.037 13.6 0.1 0.054 13.1 0.1 1.6 1 1 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain Rad51 PF08423.11 CAV26936.1 - 0.045 13.0 0.1 0.29 10.4 0.0 2.1 2 0 0 2 2 2 0 Rad51 ABC_ATPase PF09818.9 CAV26936.1 - 0.047 12.5 1.1 0.47 9.2 0.0 2.6 3 0 0 3 3 3 0 Predicted ATPase of the ABC class RsgA_GTPase PF03193.16 CAV26936.1 - 0.05 13.5 0.1 0.1 12.5 0.1 1.5 1 0 0 1 1 1 0 RsgA GTPase SbcCD_C PF13558.6 CAV26936.1 - 0.061 13.6 0.0 1.1 9.5 0.0 2.3 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit AAA_33 PF13671.6 CAV26936.1 - 0.098 12.8 0.1 0.19 11.9 0.1 1.7 1 1 0 1 1 1 0 AAA domain AAA_14 PF13173.6 CAV26936.1 - 0.13 12.2 0.1 5.5 7.0 0.0 2.4 2 0 0 2 2 2 0 AAA domain FecCD PF01032.18 CAV26938.1 - 2.2e-57 194.4 39.3 2.7e-57 194.1 39.3 1.1 1 0 0 1 1 1 1 FecCD transport family FecCD PF01032.18 CAV26942.1 - 6.1e-73 245.6 38.4 7.1e-73 245.3 38.4 1.0 1 0 0 1 1 1 1 FecCD transport family ABC-3 PF00950.17 CAV26942.1 - 0.85 9.1 31.8 0.016 14.7 25.0 1.7 2 1 0 2 2 2 0 ABC 3 transport family Peripla_BP_2 PF01497.18 CAV26943.1 - 2.2e-28 99.4 0.3 2.7e-28 99.2 0.3 1.1 1 0 0 1 1 1 1 Periplasmic binding protein DUF4375 PF14300.6 CAV26945.1 - 1.5 9.1 5.5 2.5 8.4 0.3 3.2 1 1 2 3 3 3 0 Domain of unknown function (DUF4375) Ion_trans_2 PF07885.16 CAV26947.1 - 1.7e-15 56.8 8.2 1.7e-15 56.8 8.2 3.1 2 1 0 2 2 2 1 Ion channel Ion_trans PF00520.31 CAV26947.1 - 0.00023 20.5 26.5 0.00048 19.4 26.5 1.4 1 1 0 1 1 1 1 Ion transport protein IRK PF01007.20 CAV26947.1 - 0.017 14.9 2.2 0.017 14.9 2.2 1.9 1 1 1 2 2 2 0 Inward rectifier potassium channel transmembrane domain DUF2842 PF11003.8 CAV26947.1 - 5.5 7.3 9.9 0.2 12.0 1.8 2.7 2 1 1 3 3 3 0 Protein of unknown function (DUF2842) DUF4131 PF13567.6 CAV26947.1 - 6.7 6.3 14.9 5.6 6.6 0.3 3.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4131) AI-2E_transport PF01594.16 CAV26948.1 - 7.1e-37 127.3 31.0 8e-37 127.1 31.0 1.0 1 0 0 1 1 1 1 AI-2E family transporter DUF2955 PF11168.8 CAV26950.1 - 2.1e-36 124.8 17.7 2.1e-36 124.8 17.7 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF2955) ArAE_1 PF06081.11 CAV26950.1 - 0.00021 21.4 6.3 0.00021 21.4 6.3 3.2 1 1 2 3 3 3 1 Aromatic acid exporter family member 1 Pardaxin PF07425.11 CAV26950.1 - 0.036 13.7 0.3 0.036 13.7 0.3 2.7 3 0 0 3 3 3 0 Pardaxin DUF2892 PF11127.8 CAV26950.1 - 0.14 12.3 0.3 0.14 12.3 0.3 5.2 3 2 4 7 7 7 0 Protein of unknown function (DUF2892) HlyD_D23 PF16576.5 CAV26952.1 - 7.3e-17 61.3 6.2 6.6e-15 54.9 6.2 2.2 1 1 0 1 1 1 1 Barrel-sandwich domain of CusB or HlyD membrane-fusion HlyD_3 PF13437.6 CAV26952.1 - 3.5e-16 59.8 3.1 8.2e-11 42.6 0.0 2.7 2 1 0 2 2 2 2 HlyD family secretion protein Biotin_lipoyl_2 PF13533.6 CAV26952.1 - 8.8e-15 54.3 5.9 2.8e-13 49.5 2.7 4.0 3 2 1 4 4 4 1 Biotin-lipoyl like Biotin_lipoyl PF00364.22 CAV26952.1 - 0.005 16.6 0.5 1.3 8.9 0.1 2.9 3 0 0 3 3 3 1 Biotin-requiring enzyme S1 PF00575.23 CAV26952.1 - 0.039 14.3 0.0 2.5 8.5 0.0 2.8 1 1 1 2 2 2 0 S1 RNA binding domain KH_5 PF13184.6 CAV26952.1 - 0.052 13.6 0.3 0.63 10.2 0.0 2.6 3 0 0 3 3 3 0 NusA-like KH domain DUF3584 PF12128.8 CAV26952.1 - 0.17 9.4 8.6 0.23 8.9 8.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) HlyD PF00529.20 CAV26952.1 - 0.53 10.2 3.7 1 9.3 3.7 1.7 1 1 0 1 1 1 0 HlyD membrane-fusion protein of T1SS OEP PF02321.18 CAV26952.1 - 0.69 9.7 19.4 2.8 7.7 12.2 3.0 1 1 1 2 2 2 0 Outer membrane efflux protein Arabinose_bd PF12625.7 CAV26954.1 - 0.00012 22.2 0.0 0.00017 21.7 0.0 1.2 1 0 0 1 1 1 1 Arabinose-binding domain of AraC transcription regulator, N-term HTH_18 PF12833.7 CAV26955.1 - 2e-09 37.6 0.0 2.3e-09 37.4 0.0 1.0 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 CAV26955.1 - 1.5e-07 31.3 0.1 1.8e-07 31.1 0.1 1.1 1 0 0 1 1 1 1 Bacterial regulatory helix-turn-helix proteins, AraC family HTH_35 PF13693.6 CAV26955.1 - 0.029 14.4 0.0 0.033 14.2 0.0 1.1 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding BTP PF05232.12 CAV26959.1 - 6.4e-42 141.5 18.2 2.5e-23 81.9 6.9 2.1 2 0 0 2 2 2 2 Chlorhexidine efflux transporter L6_membrane PF05805.12 CAV26959.1 - 0.056 13.0 1.8 0.077 12.6 1.4 1.5 1 1 0 1 1 1 0 L6 membrane protein GtrA PF04138.14 CAV26959.1 - 0.61 10.3 13.6 0.088 13.0 1.8 2.0 1 1 1 2 2 2 0 GtrA-like protein DUF2417 PF10329.9 CAV26959.1 - 8 5.8 11.1 0.78 9.1 1.9 2.1 1 1 1 2 2 2 0 Region of unknown function (DUF2417) LysR_substrate PF03466.20 CAV26961.1 - 1.3e-17 63.9 0.0 1.6e-17 63.5 0.0 1.1 1 0 0 1 1 1 1 LysR substrate binding domain HTH_1 PF00126.27 CAV26961.1 - 4.6e-16 58.5 0.0 8.6e-16 57.6 0.0 1.5 1 0 0 1 1 1 1 Bacterial regulatory helix-turn-helix protein, lysR family Baculo_FP PF03258.14 CAV26963.1 - 0.088 12.9 0.2 1.9 8.7 0.0 2.1 1 1 1 2 2 2 0 Baculovirus FP protein Selenoprotein_S PF06936.11 CAV26963.1 - 0.12 12.1 0.0 0.18 11.6 0.0 1.3 1 0 0 1 1 1 0 Selenoprotein S (SelS) TMP-TENI PF02581.17 CAV26964.1 - 6.3e-63 211.4 0.1 7.5e-63 211.1 0.1 1.1 1 0 0 1 1 1 1 Thiamine monophosphate synthase ThiG PF05690.14 CAV26964.1 - 0.057 12.7 0.0 0.2 10.9 0.0 1.8 2 0 0 2 2 2 0 Thiazole biosynthesis protein ThiG CppA_C PF14507.6 CAV26964.1 - 0.17 12.7 0.0 0.29 11.9 0.0 1.4 1 0 0 1 1 1 0 CppA C-terminal MCPsignal PF00015.21 CAV26967.1 - 1.6e-40 138.7 21.1 1.6e-40 138.7 21.1 4.7 3 1 2 5 5 5 3 Methyl-accepting chemotaxis protein (MCP) signalling domain HAMP PF00672.25 CAV26967.1 - 1.7e-08 34.7 1.5 2.2e-07 31.2 0.1 3.5 4 1 0 4 4 4 1 HAMP domain Phage_holin_3_6 PF07332.11 CAV26967.1 - 0.34 11.0 3.2 0.27 11.3 0.7 2.3 2 0 0 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III Lebercilin PF15619.6 CAV26967.1 - 0.46 10.1 13.7 0.27 10.9 3.4 3.3 2 1 1 3 3 3 0 Ciliary protein causing Leber congenital amaurosis disease DUF948 PF06103.11 CAV26967.1 - 0.89 9.9 42.4 0.091 13.0 4.8 5.7 4 2 2 6 6 6 0 Bacterial protein of unknown function (DUF948) Vps53_N PF04100.12 CAV26967.1 - 2.4 7.0 24.1 0.43 9.5 6.5 3.5 3 0 0 3 3 3 0 Vps53-like, N-terminal ISG65-75 PF11727.8 CAV26967.1 - 2.6 7.2 16.0 0.56 9.4 3.4 3.0 2 1 1 3 3 3 0 Invariant surface glycoprotein Folliculin PF11704.8 CAV26967.1 - 4.1 7.2 11.3 2.1 8.2 1.9 2.9 2 0 0 2 2 2 0 Vesicle coat protein involved in Golgi to plasma membrane transport HK PF02110.15 CAV26969.1 - 1.1e-71 241.1 5.6 1.3e-71 240.9 5.6 1.0 1 0 0 1 1 1 1 Hydroxyethylthiazole kinase family Carb_kinase PF01256.17 CAV26969.1 - 1.6e-07 31.1 1.5 2.5e-07 30.4 1.5 1.3 1 1 0 1 1 1 1 Carbohydrate kinase Phos_pyr_kin PF08543.12 CAV26969.1 - 1.2e-05 24.8 1.2 1.7e-05 24.4 1.2 1.2 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase DUF3392 PF11872.8 CAV26969.1 - 0.026 14.8 0.0 0.064 13.5 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3392) TENA_THI-4 PF03070.16 CAV26971.1 - 2.2e-43 148.5 0.0 2.5e-43 148.3 0.0 1.0 1 0 0 1 1 1 1 TENA/THI-4/PQQC family NMT1 PF09084.11 CAV26973.1 - 4.9e-69 232.6 0.3 5.9e-69 232.3 0.3 1.1 1 0 0 1 1 1 1 NMT1/THI5 like NMT1_2 PF13379.6 CAV26973.1 - 1.5e-06 28.1 1.5 1.8e-06 27.9 0.3 1.7 2 1 0 2 2 2 1 NMT1-like family SBP_bac_3 PF00497.20 CAV26973.1 - 3.4e-06 26.6 0.1 6.8e-06 25.7 0.1 1.4 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 Lipoprotein_9 PF03180.14 CAV26973.1 - 0.00021 20.5 0.0 0.11 11.6 0.0 2.3 2 1 0 2 2 2 2 NLPA lipoprotein BPD_transp_1 PF00528.22 CAV26975.1 - 7.5e-32 110.6 16.1 7.5e-32 110.6 16.1 1.4 2 0 0 2 2 2 1 Binding-protein-dependent transport system inner membrane component FtsX PF02687.21 CAV26975.1 - 0.014 15.8 2.7 0.014 15.8 2.7 3.0 3 1 0 3 3 3 0 FtsX-like permease family Fic_N PF13784.6 CAV26975.1 - 0.087 12.9 0.1 0.15 12.1 0.1 1.4 1 0 0 1 1 1 0 Fic/DOC family N-terminal 7TM_GPCR_Srh PF10318.9 CAV26975.1 - 5.4 5.9 12.2 0.22 10.5 4.4 2.3 1 1 0 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Srh ABC_tran PF00005.27 CAV26977.1 - 5.6e-27 94.9 0.0 8.1e-27 94.4 0.0 1.2 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 CAV26977.1 - 3.8e-07 30.2 0.0 0.019 14.8 0.0 2.1 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 CAV26977.1 - 4e-05 23.2 0.2 0.0019 17.7 0.1 2.1 2 0 0 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 CAV26977.1 - 5e-05 23.8 0.3 9e-05 22.9 0.2 1.4 1 1 0 1 1 1 1 AAA ATPase domain RsgA_GTPase PF03193.16 CAV26977.1 - 0.001 19.0 0.2 0.0023 17.9 0.1 1.6 2 0 0 2 2 2 1 RsgA GTPase AAA_5 PF07728.14 CAV26977.1 - 0.0057 16.7 0.0 0.013 15.5 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_33 PF13671.6 CAV26977.1 - 0.007 16.5 0.0 0.013 15.6 0.0 1.5 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.6 CAV26977.1 - 0.0096 16.2 0.1 0.02 15.2 0.1 1.8 1 1 0 1 1 1 1 AAA domain Rad17 PF03215.15 CAV26977.1 - 0.015 15.2 0.0 0.03 14.2 0.0 1.6 1 1 0 1 1 1 0 Rad17 P-loop domain AAA_18 PF13238.6 CAV26977.1 - 0.026 15.1 0.2 0.1 13.2 0.2 2.1 1 1 0 1 1 1 0 AAA domain AAA_30 PF13604.6 CAV26977.1 - 0.048 13.4 0.1 0.19 11.5 0.0 1.8 2 0 0 2 2 2 0 AAA domain NACHT PF05729.12 CAV26977.1 - 0.048 13.6 0.2 0.15 12.0 0.1 1.8 2 0 0 2 2 2 0 NACHT domain ATPase_2 PF01637.18 CAV26977.1 - 0.072 13.0 0.0 0.59 10.0 0.0 2.0 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea AAA_29 PF13555.6 CAV26977.1 - 0.077 12.7 0.1 0.16 11.7 0.1 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain RNA_helicase PF00910.22 CAV26977.1 - 0.09 13.2 0.0 0.24 11.8 0.0 1.7 2 0 0 2 2 2 0 RNA helicase AAA PF00004.29 CAV26977.1 - 0.1 13.1 0.0 0.31 11.4 0.0 1.9 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) SRP54 PF00448.22 CAV26977.1 - 0.14 11.8 0.0 0.22 11.1 0.0 1.3 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain AAA_15 PF13175.6 CAV26977.1 - 0.16 11.6 0.0 0.22 11.2 0.0 1.2 1 0 0 1 1 1 0 AAA ATPase domain FeoB_N PF02421.18 CAV26977.1 - 0.17 11.4 0.0 0.31 10.6 0.0 1.4 1 0 0 1 1 1 0 Ferrous iron transport protein B AAA_28 PF13521.6 CAV26977.1 - 0.17 12.1 0.1 0.46 10.7 0.0 1.7 2 0 0 2 2 2 0 AAA domain PduV-EutP PF10662.9 CAV26977.1 - 0.19 11.5 0.0 0.34 10.7 0.0 1.4 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation Phos_pyr_kin PF08543.12 CAV26979.1 - 8.6e-94 313.5 1.8 1e-93 313.3 1.8 1.0 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase PfkB PF00294.24 CAV26979.1 - 7.7e-08 32.0 0.2 1.7e-07 30.9 0.2 1.5 1 1 0 1 1 1 1 pfkB family carbohydrate kinase Carb_kinase PF01256.17 CAV26979.1 - 2.6e-06 27.1 3.6 4.3e-06 26.4 3.6 1.4 1 1 0 1 1 1 1 Carbohydrate kinase HK PF02110.15 CAV26979.1 - 0.29 10.5 5.3 0.52 9.7 2.5 2.5 1 1 0 1 1 1 0 Hydroxyethylthiazole kinase family EamA PF00892.20 CAV26981.1 - 2.3e-23 82.9 38.5 2.9e-14 53.4 16.7 2.0 2 0 0 2 2 2 2 EamA-like transporter family DUF872 PF05915.12 CAV26981.1 - 3.3 7.9 7.1 15 5.8 0.1 3.3 1 1 1 3 3 3 0 Eukaryotic protein of unknown function (DUF872) HTH_18 PF12833.7 CAV26983.1 - 2.9e-23 81.9 0.9 4.2e-23 81.4 0.2 1.7 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_AraC PF00165.23 CAV26983.1 - 1.4e-19 69.7 0.2 2.5e-08 33.8 0.0 2.5 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family Cupin_2 PF07883.11 CAV26983.1 - 0.00095 18.8 0.2 0.0016 18.1 0.2 1.2 1 0 0 1 1 1 1 Cupin domain DUF4382 PF14321.6 CAV26985.1 - 2.1e-18 66.9 0.8 3e-18 66.4 0.2 1.5 2 0 0 2 2 2 1 Domain of unknown function (DUF4382) DUF2606 PF10794.9 CAV26985.1 - 0.014 15.1 0.0 0.078 12.7 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2606) DUF2999 PF11212.8 CAV26986.1 - 1.7e-46 156.4 5.0 1.9e-46 156.2 5.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2999) GatB_Yqey PF02637.18 CAV26986.1 - 0.0046 16.9 4.9 0.017 15.0 0.1 2.4 1 1 1 2 2 2 2 GatB domain DUF218 PF02698.17 CAV26988.1 - 9.7e-19 67.7 0.0 2.7e-18 66.3 0.0 1.7 2 0 0 2 2 2 1 DUF218 domain TPR_19 PF14559.6 CAV26988.1 - 6e-05 23.5 4.8 0.006 17.1 0.1 2.7 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 CAV26988.1 - 0.00011 22.0 0.3 0.0048 16.9 0.1 3.0 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_16 PF13432.6 CAV26988.1 - 0.00076 20.1 0.3 0.003 18.2 0.3 2.1 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_14 PF13428.6 CAV26988.1 - 0.0022 18.7 1.9 0.0047 17.6 0.3 2.5 3 0 0 3 3 1 1 Tetratricopeptide repeat TPR_1 PF00515.28 CAV26988.1 - 0.0061 16.3 0.1 0.023 14.5 0.1 2.1 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_21 PF09976.9 CAV26988.1 - 0.0075 16.0 0.4 0.019 14.7 0.4 1.6 1 1 0 1 1 1 1 Tetratricopeptide repeat-like domain TPR_8 PF13181.6 CAV26988.1 - 0.014 15.5 0.1 0.041 14.1 0.1 1.9 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_11 PF13414.6 CAV26988.1 - 0.023 14.4 0.1 0.087 12.5 0.1 2.1 1 1 0 1 1 1 0 TPR repeat TPR_7 PF13176.6 CAV26988.1 - 0.047 13.7 0.0 0.25 11.5 0.0 2.3 1 0 0 1 1 1 0 Tetratricopeptide repeat DS PF01916.17 CAV26988.1 - 0.13 11.5 0.0 0.22 10.8 0.0 1.4 1 0 0 1 1 1 0 Deoxyhypusine synthase SieB PF14163.6 CAV26988.1 - 0.15 11.6 0.0 0.24 10.9 0.0 1.3 1 0 0 1 1 1 0 Super-infection exclusion protein B GST_N PF02798.20 CAV26990.1 - 5e-16 58.8 0.1 4.4e-15 55.8 0.0 2.4 3 0 0 3 3 3 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 CAV26990.1 - 1.8e-14 53.9 0.0 3.9e-14 52.8 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 CAV26990.1 - 2.4e-12 46.9 0.0 4.1e-12 46.2 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.6 CAV26990.1 - 1.3e-10 41.4 0.0 4.1e-10 39.8 0.0 1.8 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 CAV26990.1 - 3.9e-10 39.6 0.0 6.7e-10 38.9 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 CAV26990.1 - 3.8e-09 36.6 0.0 6.3e-09 35.9 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_4 PF17172.4 CAV26990.1 - 0.00012 22.8 0.0 0.00072 20.3 0.0 2.2 1 1 0 1 1 1 1 Glutathione S-transferase N-terminal domain FliH PF02108.16 CAV26991.1 - 0.033 14.3 0.5 0.065 13.3 0.5 1.4 1 0 0 1 1 1 0 Flagellar assembly protein FliH MIG-14_Wnt-bd PF06664.12 CAV26993.1 - 0.00049 19.4 0.7 0.00053 19.3 0.7 1.0 1 0 0 1 1 1 1 Wnt-binding factor required for Wnt secretion COX1 PF00115.20 CAV26993.1 - 0.0055 15.6 2.4 0.007 15.3 2.4 1.0 1 0 0 1 1 1 1 Cytochrome C and Quinol oxidase polypeptide I Cons_hypoth698 PF03601.14 CAV26993.1 - 0.066 12.1 1.6 0.088 11.7 0.3 1.6 1 1 1 2 2 2 0 Conserved hypothetical protein 698 PTPLA PF04387.14 CAV26993.1 - 0.099 12.4 0.3 0.099 12.4 0.3 1.8 1 1 1 2 2 2 0 Protein tyrosine phosphatase-like protein, PTPLA MFS_1 PF07690.16 CAV26993.1 - 0.27 10.1 5.5 0.53 9.1 5.5 1.4 1 1 0 1 1 1 0 Major Facilitator Superfamily DUF2207 PF09972.9 CAV26993.1 - 1.3 7.7 4.2 0.77 8.5 2.5 1.3 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) IMPDH PF00478.25 CAV26995.1 - 3.6e-10 39.4 0.1 4e-10 39.2 0.1 1.0 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain Phage_pRha PF09669.10 CAV26998.1 - 1.7e-27 95.8 0.2 3.7e-27 94.7 0.1 1.6 2 0 0 2 2 2 1 Phage regulatory protein Rha (Phage_pRha) POTRA_3 PF17287.2 CAV26998.1 - 0.19 11.2 0.0 2.5 7.6 0.0 2.4 2 0 0 2 2 2 0 POTRA domain Cnn_1N PF07989.11 CAV26999.1 - 5.1e-05 23.3 13.3 0.0004 20.5 9.2 2.3 1 1 1 2 2 2 2 Centrosomin N-terminal motif 1 Rootletin PF15035.6 CAV26999.1 - 6.3e-05 23.1 7.4 7.6e-05 22.8 7.4 1.1 1 0 0 1 1 1 1 Ciliary rootlet component, centrosome cohesion UPF0242 PF06785.11 CAV26999.1 - 0.00018 21.6 8.5 0.00031 20.9 8.5 1.4 1 1 0 1 1 1 1 Uncharacterised protein family (UPF0242) N-terminus TPR_MLP1_2 PF07926.12 CAV26999.1 - 0.0012 18.9 10.0 0.0015 18.6 10.0 1.2 1 0 0 1 1 1 1 TPR/MLP1/MLP2-like protein DUF4951 PF16309.5 CAV26999.1 - 0.012 15.6 0.4 0.02 15.0 0.4 1.3 1 0 0 1 1 1 0 Domian of unknown function (DUF4951) Csm1_N PF18504.1 CAV26999.1 - 0.041 14.2 9.9 0.047 14.0 8.7 1.8 1 1 0 1 1 1 0 Csm1 N-terminal domain KLRAQ PF10205.9 CAV26999.1 - 0.064 13.5 8.1 0.074 13.3 7.0 1.8 1 1 1 2 2 2 0 Predicted coiled-coil domain-containing protein Atg14 PF10186.9 CAV26999.1 - 0.11 11.6 8.8 0.12 11.5 8.8 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Spc7 PF08317.11 CAV26999.1 - 0.12 11.2 10.4 0.14 11.0 10.4 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein NVEALA PF14055.6 CAV26999.1 - 0.16 12.0 0.1 0.32 11.0 0.1 1.5 1 0 0 1 1 1 0 NVEALA protein GIT_CC PF16559.5 CAV26999.1 - 0.33 10.8 9.0 4.5 7.2 4.7 2.5 1 1 1 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor DUF4407 PF14362.6 CAV26999.1 - 1.1 8.6 8.8 1.9 7.8 8.8 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) DUF4140 PF13600.6 CAV26999.1 - 1.9 9.0 7.9 4.1 7.9 7.9 1.7 1 1 0 1 1 1 0 N-terminal domain of unknown function (DUF4140) CCDC-167 PF15188.6 CAV26999.1 - 3.3 8.1 12.6 10 6.5 12.6 2.0 1 1 0 1 1 1 0 Coiled-coil domain-containing protein 167 DUF2681 PF10883.8 CAV26999.1 - 4.2 7.8 8.7 56 4.2 8.3 2.3 1 1 0 1 1 1 0 Protein of unknown function (DUF2681) BaxI_1 PF12811.7 CAV27003.1 - 0.02 14.5 8.0 0.095 12.3 8.0 1.9 1 1 0 1 1 1 0 Bax inhibitor 1 like DUF1980 PF09323.10 CAV27003.1 - 0.057 13.3 0.1 0.12 12.3 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) DUF1427 PF07235.11 CAV27003.1 - 0.16 11.9 0.5 0.37 10.8 0.5 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1427) PEX11 PF05648.14 CAV27003.1 - 0.21 11.0 2.1 0.37 10.2 1.1 1.8 2 0 0 2 2 2 0 Peroxisomal biogenesis factor 11 (PEX11) CcmD PF04995.14 CAV27003.1 - 0.76 9.9 3.4 3.1 8.0 0.0 2.6 2 0 0 2 2 2 0 Heme exporter protein D (CcmD) XisH PF08814.10 CAV27004.1 - 0.064 13.4 0.1 0.085 13.0 0.1 1.1 1 0 0 1 1 1 0 XisH protein FliH PF02108.16 CAV27004.1 - 0.11 12.6 1.1 0.15 12.1 1.1 1.1 1 0 0 1 1 1 0 Flagellar assembly protein FliH DUF2079 PF09852.9 CAV27006.1 - 1.2e-05 24.4 0.4 1.9e-05 23.7 0.2 1.3 1 1 0 1 1 1 1 Predicted membrane protein (DUF2079) DUF2417 PF10329.9 CAV27006.1 - 0.1 12.0 2.7 0.074 12.5 0.7 1.6 1 1 1 2 2 2 0 Region of unknown function (DUF2417) SUR7 PF06687.12 CAV27006.1 - 0.21 11.2 6.1 2.4 7.7 6.3 2.1 1 1 0 1 1 1 0 SUR7/PalI family Reticulon PF02453.17 CAV27006.1 - 0.73 9.8 0.1 0.73 9.8 0.1 2.4 2 1 0 2 2 2 0 Reticulon DUF2663 PF10864.8 CAV27007.1 - 0.0023 18.4 0.6 0.0023 18.4 0.6 1.8 1 1 1 2 2 2 1 Protein of unknown function (DUF2663) MASE4 PF17158.4 CAV27007.1 - 0.0063 15.8 2.4 0.0077 15.5 2.4 1.1 1 0 0 1 1 1 1 Membrane-associated sensor, integral membrane domain DUF4112 PF13430.6 CAV27007.1 - 0.026 14.8 1.4 0.043 14.1 0.8 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4112) Yip1 PF04893.17 CAV27007.1 - 0.088 12.5 5.6 0.21 11.3 5.7 1.4 1 1 0 1 1 1 0 Yip1 domain DUF805 PF05656.14 CAV27007.1 - 0.24 11.8 1.3 0.33 11.4 1.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF805) DUF4519 PF15012.6 CAV27007.1 - 0.4 10.9 2.0 0.96 9.7 0.3 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4519) MgtE PF01769.16 CAV27007.1 - 0.82 10.1 7.1 2.2 8.7 7.1 1.9 1 1 0 1 1 1 0 Divalent cation transporter FixS PF03597.15 CAV27007.1 - 1.2 8.9 0.0 1.2 8.9 0.0 2.7 2 1 1 3 3 3 0 Cytochrome oxidase maturation protein cbb3-type Ion_trans PF00520.31 CAV27009.1 - 0.025 13.8 2.4 0.032 13.5 2.4 1.2 1 0 0 1 1 1 0 Ion transport protein MFS_1 PF07690.16 CAV27009.1 - 0.2 10.6 7.8 0.29 10.0 7.8 1.3 1 1 0 1 1 1 0 Major Facilitator Superfamily IMPDH PF00478.25 CAV27011.1 - 9.9e-82 274.7 5.6 1.2e-81 274.4 5.6 1.0 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain NBD_C PF17042.5 CAV27011.1 - 0.0054 17.3 0.1 0.0085 16.6 0.1 1.3 1 0 0 1 1 1 1 Nucleotide-binding C-terminal domain Aldolase PF01081.19 CAV27011.1 - 0.045 13.2 0.2 0.045 13.2 0.2 2.8 2 1 1 3 3 3 0 KDPG and KHG aldolase DUF561 PF04481.12 CAV27011.1 - 0.11 11.6 0.4 0.2 10.8 0.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF561) G3P_antiterm PF04309.12 CAV27011.1 - 0.12 11.7 0.4 0.69 9.3 0.4 1.9 1 1 1 2 2 2 0 Glycerol-3-phosphate responsive antiterminator Radical_SAM PF04055.21 CAV27011.1 - 0.13 12.6 0.0 0.22 11.9 0.0 1.3 1 0 0 1 1 1 0 Radical SAM superfamily FMN_dh PF01070.18 CAV27011.1 - 0.65 9.0 13.1 2.4 7.1 9.9 2.7 1 1 2 3 3 3 0 FMN-dependent dehydrogenase DHO_dh PF01180.21 CAV27011.1 - 3.4 6.8 9.3 0.38 9.9 0.3 2.3 2 1 0 2 2 2 0 Dihydroorotate dehydrogenase PAS PF00989.25 CAV27012.1 - 1.5e-07 31.4 0.0 2.8e-06 27.3 0.0 2.1 1 1 0 1 1 1 1 PAS fold PAS_4 PF08448.10 CAV27012.1 - 5.6e-06 26.6 0.0 0.00065 19.9 0.0 2.2 1 1 1 2 2 2 2 PAS fold PAS_9 PF13426.7 CAV27012.1 - 0.00016 21.9 0.0 0.00021 21.5 0.0 1.2 1 0 0 1 1 1 1 PAS domain Response_reg PF00072.24 CAV27014.1 - 9.3e-23 80.5 0.1 1.7e-22 79.7 0.1 1.4 1 0 0 1 1 1 1 Response regulator receiver domain CheX PF13690.6 CAV27014.1 - 0.0052 16.9 0.0 1.1 9.5 0.0 2.5 2 0 0 2 2 2 2 Chemotaxis phosphatase CheX DUF202 PF02656.15 CAV27016.1 - 0.046 14.2 2.5 3.6 8.1 1.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF202) YiaAB PF05360.14 CAV27016.1 - 0.24 11.7 4.8 0.38 11.0 0.5 2.2 2 0 0 2 2 2 0 yiaA/B two helix domain MatE PF01554.18 CAV27018.1 - 1.6e-36 125.4 48.8 5e-19 68.5 15.4 3.1 3 0 0 3 3 3 2 MatE Polysacc_synt_C PF14667.6 CAV27018.1 - 0.00026 21.1 13.9 0.00026 21.1 13.9 4.6 3 3 1 4 4 4 1 Polysaccharide biosynthesis C-terminal domain HTH_1 PF00126.27 CAV27020.1 - 1.4e-19 69.8 0.7 2.3e-19 69.1 0.7 1.4 1 0 0 1 1 1 1 Bacterial regulatory helix-turn-helix protein, lysR family LysR_substrate PF03466.20 CAV27020.1 - 1e-12 47.9 0.0 1.6e-12 47.3 0.0 1.3 1 0 0 1 1 1 1 LysR substrate binding domain HTH_5 PF01022.20 CAV27020.1 - 0.016 15.0 0.4 0.045 13.6 0.0 1.9 2 0 0 2 2 2 0 Bacterial regulatory protein, arsR family MarR_2 PF12802.7 CAV27020.1 - 0.027 14.4 0.3 0.06 13.2 0.1 1.7 2 0 0 2 2 2 0 MarR family HTH_11 PF08279.12 CAV27020.1 - 0.03 14.3 0.1 0.082 12.9 0.1 1.7 1 0 0 1 1 1 0 HTH domain MarR PF01047.22 CAV27020.1 - 0.036 14.0 0.0 0.14 12.1 0.0 1.9 1 0 0 1 1 1 0 MarR family HTH_24 PF13412.6 CAV27020.1 - 0.051 13.2 0.0 0.097 12.2 0.0 1.5 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding HTH_50 PF18024.1 CAV27020.1 - 0.1 12.2 0.5 0.23 11.1 0.0 1.8 2 0 0 2 2 2 0 Helix-turn-helix domain Mga PF05043.13 CAV27020.1 - 0.18 12.4 0.9 8.2 7.1 0.0 2.9 3 0 0 3 3 3 0 Mga helix-turn-helix domain Tup_N PF08581.10 CAV27020.1 - 0.32 11.3 0.1 0.32 11.3 0.1 2.2 3 0 0 3 3 3 0 Tup N-terminal EamA PF00892.20 CAV27022.1 - 4.4e-25 88.4 34.6 5.9e-15 55.6 8.9 2.1 2 0 0 2 2 2 2 EamA-like transporter family Glyoxalase_4 PF13669.6 CAV27024.1 - 1.2e-08 35.1 0.0 2.7e-08 34.0 0.0 1.6 1 1 1 2 2 2 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase PF00903.25 CAV27024.1 - 3e-08 33.9 0.3 8e-08 32.5 0.3 1.6 1 1 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_6 PF18029.1 CAV27024.1 - 0.0042 17.8 0.0 0.0054 17.5 0.0 1.1 1 0 0 1 1 1 1 Glyoxalase-like domain DUF3081 PF11280.8 CAV27025.1 - 1e-28 98.9 1.1 1.2e-28 98.7 1.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3081) CIA30 PF08547.12 CAV27027.1 - 9.7e-38 129.7 0.7 1.2e-37 129.4 0.7 1.1 1 0 0 1 1 1 1 Complex I intermediate-associated protein 30 (CIA30) ADH_zinc_N_2 PF13602.6 CAV27029.1 - 6.9e-16 59.5 0.2 1.6e-15 58.4 0.1 1.7 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.26 CAV27029.1 - 1.2e-12 47.9 0.0 2.8e-12 46.8 0.0 1.6 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_N PF08240.12 CAV27029.1 - 5.8e-08 32.6 0.0 1.1e-07 31.7 0.0 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_N_2 PF16884.5 CAV27029.1 - 0.00023 21.0 0.0 0.00038 20.3 0.0 1.4 1 0 0 1 1 1 1 N-terminal domain of oxidoreductase Epimerase PF01370.21 CAV27029.1 - 0.0063 16.0 0.1 0.01 15.3 0.1 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family TrkA_N PF02254.18 CAV27029.1 - 0.0097 16.2 0.0 0.03 14.6 0.0 1.9 1 0 0 1 1 1 1 TrkA-N domain Sacchrp_dh_NADP PF03435.18 CAV27029.1 - 0.04 14.2 0.1 0.089 13.1 0.1 1.6 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain Semialdhyde_dh PF01118.24 CAV27029.1 - 0.068 13.6 0.1 0.15 12.5 0.1 1.6 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain LysR_substrate PF03466.20 CAV27031.1 - 5.5e-38 130.4 0.0 7.5e-38 130.0 0.0 1.2 1 0 0 1 1 1 1 LysR substrate binding domain HTH_1 PF00126.27 CAV27031.1 - 4.3e-14 52.2 3.3 8.1e-14 51.3 3.3 1.5 1 0 0 1 1 1 1 Bacterial regulatory helix-turn-helix protein, lysR family PAS_3 PF08447.12 CAV27033.1 - 0.049 13.9 0.0 0.096 13.0 0.0 1.4 1 0 0 1 1 1 0 PAS fold ABC_tran PF00005.27 CAV27035.1 - 2.1e-29 102.8 0.0 3e-29 102.3 0.0 1.2 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 CAV27035.1 - 1.7e-10 41.2 0.0 1.4e-05 25.1 0.0 2.1 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 CAV27035.1 - 4.4e-08 32.8 0.2 0.0071 15.8 0.0 2.1 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_15 PF13175.6 CAV27035.1 - 5.6e-07 29.6 0.2 0.00032 20.5 0.0 2.1 2 0 0 2 2 2 2 AAA ATPase domain AAA_16 PF13191.6 CAV27035.1 - 0.00027 21.4 0.0 0.00078 19.9 0.0 1.8 1 1 0 1 1 1 1 AAA ATPase domain RsgA_GTPase PF03193.16 CAV27035.1 - 0.00029 20.8 0.1 0.00058 19.8 0.1 1.5 1 0 0 1 1 1 1 RsgA GTPase AAA_29 PF13555.6 CAV27035.1 - 0.00034 20.3 0.1 0.00085 19.0 0.1 1.7 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_22 PF13401.6 CAV27035.1 - 0.00039 20.7 0.3 0.0037 17.5 0.0 2.1 2 0 0 2 2 2 1 AAA domain ATPase_2 PF01637.18 CAV27035.1 - 0.00061 19.8 0.0 0.0055 16.6 0.0 2.0 1 1 0 1 1 1 1 ATPase domain predominantly from Archaea AAA_23 PF13476.6 CAV27035.1 - 0.00077 20.0 0.2 0.0013 19.3 0.2 1.3 1 0 0 1 1 1 1 AAA domain ABC_ATPase PF09818.9 CAV27035.1 - 0.0024 16.8 0.5 0.062 12.1 0.1 2.1 2 0 0 2 2 2 1 Predicted ATPase of the ABC class AAA_25 PF13481.6 CAV27035.1 - 0.0034 17.0 0.2 0.013 15.1 0.0 1.9 2 0 0 2 2 2 1 AAA domain AAA_14 PF13173.6 CAV27035.1 - 0.0034 17.4 0.1 0.014 15.4 0.0 1.9 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.6 CAV27035.1 - 0.0054 16.9 0.0 0.0093 16.1 0.0 1.6 1 1 0 1 1 1 1 AAA domain Rad17 PF03215.15 CAV27035.1 - 0.0059 16.6 0.1 0.012 15.5 0.1 1.5 1 0 0 1 1 1 1 Rad17 P-loop domain ATP_bind_1 PF03029.17 CAV27035.1 - 0.0069 16.2 0.3 1.5 8.6 0.1 2.1 2 0 0 2 2 2 1 Conserved hypothetical ATP binding protein NACHT PF05729.12 CAV27035.1 - 0.0077 16.2 0.0 0.068 13.1 0.1 2.2 2 0 0 2 2 2 1 NACHT domain NYN PF01936.18 CAV27035.1 - 0.011 16.3 0.0 0.015 15.8 0.0 1.2 1 0 0 1 1 1 0 NYN domain cobW PF02492.19 CAV27035.1 - 0.019 14.6 0.1 0.52 9.9 0.0 2.2 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_28 PF13521.6 CAV27035.1 - 0.027 14.7 0.1 0.065 13.5 0.1 1.6 1 0 0 1 1 1 0 AAA domain MMR_HSR1 PF01926.23 CAV27035.1 - 0.035 14.2 0.2 0.28 11.3 0.0 2.1 2 0 0 2 2 2 0 50S ribosome-binding GTPase AAA_5 PF07728.14 CAV27035.1 - 0.036 14.1 0.2 0.48 10.4 0.0 2.2 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_24 PF13479.6 CAV27035.1 - 0.04 13.6 0.4 0.17 11.6 0.1 1.9 2 0 0 2 2 2 0 AAA domain AAA PF00004.29 CAV27035.1 - 0.046 14.2 0.1 0.36 11.2 0.0 2.1 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.6 CAV27035.1 - 0.055 14.0 0.1 0.35 11.4 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_30 PF13604.6 CAV27035.1 - 0.062 13.0 1.6 0.46 10.2 1.6 2.0 1 1 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 CAV27035.1 - 0.07 13.5 0.1 0.24 11.8 0.0 1.9 2 0 0 2 2 2 0 RNA helicase Mg_chelatase PF01078.21 CAV27035.1 - 0.087 12.2 0.0 0.14 11.6 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI Adeno_IVa2 PF02456.15 CAV27035.1 - 0.095 11.5 0.4 0.36 9.6 0.1 1.8 2 0 0 2 2 2 0 Adenovirus IVa2 protein BCA_ABC_TP_C PF12399.8 CAV27035.1 - 0.12 12.3 0.0 0.24 11.3 0.0 1.5 1 0 0 1 1 1 0 Branched-chain amino acid ATP-binding cassette transporter ATP-synt_ab PF00006.25 CAV27035.1 - 0.13 11.9 0.1 0.18 11.4 0.1 1.5 1 1 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain KAP_NTPase PF07693.14 CAV27035.1 - 0.13 11.5 0.0 0.17 11.1 0.0 1.1 1 0 0 1 1 1 0 KAP family P-loop domain MukB PF04310.12 CAV27035.1 - 0.14 12.0 0.1 3.3 7.5 0.0 2.1 2 0 0 2 2 2 0 MukB N-terminal FeoB_N PF02421.18 CAV27035.1 - 0.35 10.4 2.3 2.4 7.7 0.1 2.3 2 0 0 2 2 2 0 Ferrous iron transport protein B AAA_19 PF13245.6 CAV27035.1 - 0.69 10.2 3.2 3.9 7.8 3.2 2.0 1 1 0 1 1 1 0 AAA domain FecCD PF01032.18 CAV27037.1 - 2e-94 316.1 32.5 2.4e-94 315.8 32.5 1.0 1 0 0 1 1 1 1 FecCD transport family FecCD PF01032.18 CAV27039.1 - 4.1e-82 275.7 30.6 5.3e-82 275.3 30.6 1.2 1 0 0 1 1 1 1 FecCD transport family ABC-3 PF00950.17 CAV27039.1 - 5.6 6.4 19.9 0.31 10.5 14.4 1.6 2 0 0 2 2 2 0 ABC 3 transport family Phage_holin_3_1 PF05106.12 CAV27039.1 - 6.6 7.2 11.6 4.4 7.8 1.6 4.0 2 1 0 3 3 3 0 Phage holin family (Lysis protein S) Peripla_BP_2 PF01497.18 CAV27040.1 - 7.6e-25 87.9 0.1 9.2e-25 87.6 0.1 1.1 1 0 0 1 1 1 1 Periplasmic binding protein TonB_dep_Rec PF00593.24 CAV27042.1 - 2.8e-45 156.1 29.8 2.8e-45 156.1 29.8 1.3 1 1 0 1 1 1 1 TonB dependent receptor Plug PF07715.15 CAV27042.1 - 3.4e-23 82.3 0.6 1.5e-22 80.2 0.4 2.2 2 0 0 2 2 2 1 TonB-dependent Receptor Plug Domain OMP_b-brl_3 PF14905.6 CAV27042.1 - 7.4e-10 38.4 7.0 8.7e-05 21.7 0.1 2.3 2 0 0 2 2 2 2 Outer membrane protein beta-barrel family TonB_dep_Rec PF00593.24 CAV27043.1 - 1.1e-45 157.4 20.8 1.1e-45 157.4 20.8 1.4 1 1 0 1 1 1 1 TonB dependent receptor Plug PF07715.15 CAV27043.1 - 2.7e-23 82.6 0.7 7.1e-23 81.2 0.7 1.7 1 0 0 1 1 1 1 TonB-dependent Receptor Plug Domain DUF2490 PF10677.9 CAV27043.1 - 0.079 12.9 2.7 1.4 8.9 0.0 3.2 3 1 0 3 3 3 0 Protein of unknown function (DUF2490) ATP-grasp_3 PF02655.14 CAV27045.1 - 6.1e-06 26.4 0.0 0.00012 22.2 0.0 2.2 1 1 0 1 1 1 1 ATP-grasp domain ATP-grasp_4 PF13535.6 CAV27045.1 - 4.2e-05 23.2 0.0 0.0016 18.1 0.0 2.6 1 1 0 1 1 1 1 ATP-grasp domain Dala_Dala_lig_C PF07478.13 CAV27045.1 - 0.00032 20.3 0.0 0.00054 19.6 0.0 1.4 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus GARS_A PF01071.19 CAV27045.1 - 0.0066 16.2 0.0 3.3 7.4 0.0 2.3 2 0 0 2 2 2 2 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain ATPgrasp_N PF18130.1 CAV27045.1 - 0.055 14.0 0.0 0.11 13.1 0.0 1.5 1 0 0 1 1 1 0 ATP-grasp N-terminal domain IucA_IucC PF04183.12 CAV27047.1 - 1.2e-30 106.8 0.0 4.8e-30 104.9 0.0 2.0 1 1 0 1 1 1 1 IucA / IucC family FhuF PF06276.12 CAV27047.1 - 2.7e-14 53.9 0.2 8.1e-14 52.4 0.2 1.8 1 0 0 1 1 1 1 Ferric iron reductase FhuF-like transporter MFS_1 PF07690.16 CAV27048.1 - 1.7e-26 93.0 34.5 1.1e-15 57.4 21.7 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 CAV27048.1 - 3.2e-05 23.0 4.8 3.2e-05 23.0 4.8 2.6 3 0 0 3 3 3 2 Sugar (and other) transporter IucA_IucC PF04183.12 CAV27050.1 - 4.3e-51 173.8 0.0 6.9e-51 173.1 0.0 1.3 1 0 0 1 1 1 1 IucA / IucC family FhuF PF06276.12 CAV27050.1 - 6.4e-30 104.7 0.0 1.3e-29 103.7 0.0 1.5 1 0 0 1 1 1 1 Ferric iron reductase FhuF-like transporter Orn_Arg_deC_N PF02784.16 CAV27052.1 - 3.8e-32 111.6 0.0 4.8e-32 111.3 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, pyridoxal binding domain Orn_DAP_Arg_deC PF00278.22 CAV27052.1 - 2.1e-15 56.7 0.0 2.2e-15 56.7 0.0 1.2 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, C-terminal sheet domain Ala_racemase_N PF01168.20 CAV27052.1 - 5.2e-10 39.3 0.0 9.1e-10 38.6 0.0 1.4 1 0 0 1 1 1 1 Alanine racemase, N-terminal domain Acetate_kinase PF00871.17 CAV27055.1 - 6.7e-142 472.8 0.1 7.6e-142 472.6 0.1 1.0 1 0 0 1 1 1 1 Acetokinase family ROK PF00480.20 CAV27055.1 - 0.0059 16.1 0.0 0.011 15.3 0.0 1.3 1 0 0 1 1 1 1 ROK family DEAD PF00270.29 CAV27059.1 - 2.5e-49 167.4 0.0 5.2e-49 166.4 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CAV27059.1 - 2.1e-32 111.8 0.4 7.4e-30 103.6 0.0 3.2 3 0 0 3 3 3 1 Helicase conserved C-terminal domain DbpA PF03880.15 CAV27059.1 - 2.9e-15 56.0 0.0 6.7e-15 54.8 0.0 1.6 1 0 0 1 1 1 1 DbpA RNA binding domain ResIII PF04851.15 CAV27059.1 - 2.5e-05 24.3 0.0 6.2e-05 23.1 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit CMS1 PF14617.6 CAV27059.1 - 0.0013 18.1 0.1 0.03 13.7 0.0 2.5 2 0 0 2 2 2 1 U3-containing 90S pre-ribosomal complex subunit RNB PF00773.19 CAV27060.1 - 6.5e-85 285.3 0.0 9e-85 284.9 0.0 1.2 1 0 0 1 1 1 1 RNB domain OB_RNB PF08206.11 CAV27060.1 - 8.1e-17 60.7 0.1 2.9e-16 58.9 0.0 2.1 2 0 0 2 2 2 1 Ribonuclease B OB domain CSD2 PF17876.1 CAV27060.1 - 2.5e-12 46.8 0.3 3.7e-08 33.4 0.1 2.8 2 0 0 2 2 2 2 Cold shock domain S1 PF00575.23 CAV27060.1 - 6e-10 39.3 0.2 7.7e-09 35.8 0.1 2.4 2 0 0 2 2 2 1 S1 RNA binding domain HTH_18 PF12833.7 CAV27062.1 - 1.3e-19 70.2 0.7 2.4e-19 69.4 0.7 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 CAV27062.1 - 2.5e-14 53.0 1.2 1.8e-09 37.4 0.4 2.9 2 1 1 3 3 3 2 Bacterial regulatory helix-turn-helix proteins, AraC family AraC_binding PF02311.19 CAV27062.1 - 0.0031 17.4 0.0 0.0078 16.1 0.0 1.8 1 1 0 1 1 1 1 AraC-like ligand binding domain HTH_3 PF01381.22 CAV27062.1 - 0.025 14.6 0.1 0.069 13.2 0.1 1.8 1 0 0 1 1 1 0 Helix-turn-helix HTH_Crp_2 PF13545.6 CAV27062.1 - 0.039 13.9 0.1 0.081 12.9 0.1 1.6 1 0 0 1 1 1 0 Crp-like helix-turn-helix domain HTH_Mga PF08280.11 CAV27062.1 - 0.039 14.0 0.1 1.5 8.9 0.0 2.7 1 1 1 2 2 2 0 M protein trans-acting positive regulator (MGA) HTH domain PPC PF04151.15 CAV27062.1 - 0.1 13.7 0.6 0.24 12.5 0.3 1.9 2 0 0 2 2 2 0 Bacterial pre-peptidase C-terminal domain HTH_11 PF08279.12 CAV27062.1 - 0.11 12.5 0.0 0.22 11.5 0.0 1.5 1 0 0 1 1 1 0 HTH domain SapB_1 PF05184.15 CAV27062.1 - 2.5 8.2 4.0 6.8 6.8 0.1 2.7 3 0 0 3 3 3 0 Saposin-like type B, region 1 DUF3024 PF11225.8 CAV27064.1 - 2.8e-20 72.3 0.0 3.6e-20 72.0 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3024) PBP_like PF12727.7 CAV27066.1 - 5e-39 133.4 0.0 6e-39 133.2 0.0 1.1 1 0 0 1 1 1 1 PBP superfamily domain PBP_like_2 PF12849.7 CAV27066.1 - 1.2e-35 123.6 0.7 5.5e-35 121.4 0.7 1.8 1 1 0 1 1 1 1 PBP superfamily domain SBP_bac_11 PF13531.6 CAV27066.1 - 4.5e-08 33.1 0.0 9.5e-08 32.1 0.0 1.5 1 1 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_1 PF01547.25 CAV27066.1 - 0.13 12.2 0.1 0.26 11.2 0.1 1.7 1 1 0 1 1 1 0 Bacterial extracellular solute-binding protein DUF2541 PF10807.8 CAV27066.1 - 0.64 10.1 3.4 14 5.7 0.2 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF2541) MaoC_dehydratas PF01575.19 CAV27068.1 - 4.7e-20 71.4 0.0 6.5e-20 70.9 0.0 1.2 1 0 0 1 1 1 1 MaoC like domain ACR_tran PF00873.19 CAV27070.1 - 0 1061.9 22.4 0 1061.7 22.4 1.0 1 0 0 1 1 1 1 AcrB/AcrD/AcrF family MMPL PF03176.15 CAV27070.1 - 8.4e-10 38.1 26.2 7e-07 28.5 13.3 2.7 2 0 0 2 2 2 2 MMPL family SecD_SecF PF02355.16 CAV27070.1 - 1.5e-05 24.5 28.6 0.00036 20.0 18.1 2.4 2 0 0 2 2 2 2 Protein export membrane protein HSP90 PF00183.18 CAV27070.1 - 0.044 12.7 0.0 0.064 12.1 0.0 1.1 1 0 0 1 1 1 0 Hsp90 protein Patched PF02460.18 CAV27070.1 - 0.12 10.4 22.3 0.028 12.5 18.6 1.8 2 0 0 2 2 2 0 Patched family Helicase_C_3 PF13625.6 CAV27070.1 - 0.17 12.0 0.4 8.1 6.6 0.0 3.2 4 0 0 4 4 4 0 Helicase conserved C-terminal domain HlyD_3 PF13437.6 CAV27071.1 - 3.6e-13 50.1 0.1 2.5e-06 28.1 0.0 3.5 3 1 1 4 4 4 2 HlyD family secretion protein HlyD_D23 PF16576.5 CAV27071.1 - 4.2e-13 49.0 0.7 1.9e-12 46.9 0.1 2.4 2 1 0 2 2 2 1 Barrel-sandwich domain of CusB or HlyD membrane-fusion Biotin_lipoyl_2 PF13533.6 CAV27071.1 - 1.2e-10 41.0 0.2 3.7e-08 33.1 0.0 3.0 2 1 0 2 2 2 1 Biotin-lipoyl like OEP PF02321.18 CAV27071.1 - 0.00022 21.1 4.4 0.00036 20.4 4.4 1.3 1 0 0 1 1 1 1 Outer membrane efflux protein Biotin_lipoyl PF00364.22 CAV27071.1 - 0.0013 18.5 0.1 0.18 11.6 0.0 3.0 3 0 0 3 3 3 1 Biotin-requiring enzyme Peptidase_M23 PF01551.22 CAV27071.1 - 0.0027 17.9 0.1 0.087 13.0 0.1 2.7 2 0 0 2 2 2 1 Peptidase family M23 HlyD PF00529.20 CAV27071.1 - 0.026 14.4 0.0 0.16 11.8 0.0 2.2 2 1 0 2 2 2 0 HlyD membrane-fusion protein of T1SS PTS_EIIA_1 PF00358.20 CAV27071.1 - 0.043 13.6 0.0 2.8 7.7 0.0 3.0 2 1 1 3 3 3 0 phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1 LPAM_2 PF13627.6 CAV27071.1 - 0.43 10.5 3.6 0.75 9.7 3.6 1.4 1 0 0 1 1 1 0 Prokaryotic lipoprotein-attachment site dCMP_cyt_deam_1 PF00383.23 CAV27073.1 - 4.9e-24 84.1 0.0 5.8e-24 83.9 0.0 1.1 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 CAV27073.1 - 6.9e-12 45.3 0.0 8.2e-12 45.1 0.0 1.1 1 0 0 1 1 1 1 MafB19-like deaminase APOBEC3 PF18771.1 CAV27073.1 - 0.0011 19.1 0.1 0.0016 18.5 0.1 1.2 1 0 0 1 1 1 1 APOBEC3 DUF1610 PF07754.11 CAV27073.1 - 0.9 9.6 7.7 0.66 10.0 4.6 2.4 3 0 0 3 3 3 0 Domain of unknown function (DUF1610) MS_channel PF00924.18 CAV27075.1 - 1.7e-16 60.4 3.5 1.7e-16 60.4 3.5 1.9 2 1 0 2 2 2 1 Mechanosensitive ion channel DM13 PF10517.9 CAV27077.1 - 4.8e-20 72.1 0.0 1.1e-19 71.0 0.0 1.5 1 1 1 2 2 2 1 Electron transfer DM13 Peptidase_M20 PF01546.28 CAV27079.1 - 6.4e-13 48.9 0.8 1.7e-12 47.5 0.3 1.8 2 0 0 2 2 2 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 CAV27079.1 - 1.1e-09 38.2 0.0 1.9e-09 37.4 0.0 1.4 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M42 PF05343.14 CAV27079.1 - 6.2e-09 35.3 0.1 0.00058 19.0 0.0 2.6 3 0 0 3 3 3 2 M42 glutamyl aminopeptidase N2227 PF07942.12 CAV27079.1 - 0.14 11.3 0.0 0.21 10.7 0.0 1.2 1 0 0 1 1 1 0 N2227-like protein Aldo_ket_red PF00248.21 CAV27084.1 - 9.2e-66 222.0 0.0 1e-65 221.8 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family SpoU_methylase PF00588.19 CAV27085.1 - 9.2e-30 103.7 0.0 1.6e-29 102.9 0.0 1.4 1 0 0 1 1 1 1 SpoU rRNA Methylase family DUF3470 PF11953.8 CAV27087.1 - 5.1e-17 61.6 0.6 7e-17 61.1 0.6 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3470) Fer4_9 PF13187.6 CAV27087.1 - 5.6e-07 29.6 10.7 1e-06 28.8 10.7 1.4 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_6 PF12837.7 CAV27087.1 - 5.8e-07 29.3 15.4 0.00079 19.4 3.2 2.4 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_17 PF13534.6 CAV27087.1 - 1.5e-06 28.7 3.4 0.0055 17.2 0.1 2.2 2 0 0 2 2 2 2 4Fe-4S dicluster domain Fer4_7 PF12838.7 CAV27087.1 - 1.5e-06 28.7 20.2 0.0005 20.6 12.7 2.2 1 1 2 3 3 3 3 4Fe-4S dicluster domain Fer4_16 PF13484.6 CAV27087.1 - 1.7e-06 28.9 5.9 0.018 15.9 1.3 2.2 2 0 0 2 2 2 2 4Fe-4S double cluster binding domain Fer4 PF00037.27 CAV27087.1 - 3.2e-06 26.7 17.6 0.00022 20.9 5.3 3.1 3 0 0 3 3 3 2 4Fe-4S binding domain Fer4_21 PF14697.6 CAV27087.1 - 2.1e-05 24.6 9.2 0.0034 17.5 1.0 2.2 2 0 0 2 2 2 2 4Fe-4S dicluster domain Fer4_10 PF13237.6 CAV27087.1 - 5.3e-05 23.2 11.6 0.00065 19.8 12.3 2.0 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_8 PF13183.6 CAV27087.1 - 0.00012 22.5 3.0 0.033 14.6 0.0 2.2 2 0 0 2 2 2 2 4Fe-4S dicluster domain Fer4_2 PF12797.7 CAV27087.1 - 0.00021 21.2 12.3 0.0095 16.0 2.9 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_4 PF12800.7 CAV27087.1 - 0.0022 18.3 14.2 0.028 14.9 3.0 2.2 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_18 PF13746.6 CAV27087.1 - 0.055 13.7 11.4 0.12 12.6 11.4 1.5 1 1 0 1 1 1 0 4Fe-4S dicluster domain Fer4_3 PF12798.7 CAV27087.1 - 0.21 12.6 16.0 0.32 12.1 4.2 2.3 2 0 0 2 2 2 0 4Fe-4S binding domain Fer4_13 PF13370.6 CAV27087.1 - 0.26 11.9 13.9 1.8 9.1 4.9 2.4 2 1 0 2 2 2 0 4Fe-4S single cluster domain of Ferredoxin I Fer4_11 PF13247.6 CAV27087.1 - 1.1 9.5 8.8 1.3 9.2 1.8 2.1 1 1 1 2 2 2 0 4Fe-4S dicluster domain DAO PF01266.24 CAV27089.1 - 1.1e-06 28.5 0.0 0.00018 21.2 0.0 2.6 1 1 0 2 2 2 1 FAD dependent oxidoreductase HI0933_like PF03486.14 CAV27089.1 - 5.2e-06 25.4 0.0 0.012 14.3 0.0 2.2 2 0 0 2 2 2 2 HI0933-like protein Pyr_redox_2 PF07992.14 CAV27089.1 - 6.4e-06 25.6 0.1 0.017 14.3 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 CAV27089.1 - 8.3e-06 25.1 0.1 0.046 12.8 0.0 2.8 3 0 0 3 3 3 2 FAD binding domain Pyr_redox_3 PF13738.6 CAV27089.1 - 7.7e-05 22.1 0.4 0.0014 17.9 0.1 2.3 1 1 1 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Amino_oxidase PF01593.24 CAV27089.1 - 0.00011 21.7 0.1 0.00086 18.7 0.0 2.4 3 0 0 3 3 3 1 Flavin containing amine oxidoreductase GIDA PF01134.22 CAV27089.1 - 0.0016 17.6 0.1 0.09 11.8 0.0 2.6 3 0 0 3 3 3 1 Glucose inhibited division protein A FAD_binding_3 PF01494.19 CAV27089.1 - 0.0024 17.2 0.1 0.0073 15.6 0.1 1.8 1 1 0 1 1 1 1 FAD binding domain NAD_binding_9 PF13454.6 CAV27089.1 - 0.096 12.7 1.6 0.23 11.4 0.0 2.3 3 0 0 3 3 3 0 FAD-NAD(P)-binding DUF2393 PF09624.10 CAV27091.1 - 0.29 11.1 1.6 0.66 10.0 1.6 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2393) SBP_bac_5 PF00496.22 CAV27092.1 - 1.2e-21 77.1 0.0 2.7e-21 76.0 0.0 1.5 2 0 0 2 2 2 1 Bacterial extracellular solute-binding proteins, family 5 Middle SgrR_N PF12793.7 CAV27092.1 - 2.8e-15 56.5 0.1 7.1e-15 55.2 0.1 1.6 1 0 0 1 1 1 1 Sugar transport-related sRNA regulator N-term Nitroreductase PF00881.24 CAV27093.1 - 1e-26 94.0 0.0 2e-26 93.1 0.0 1.5 2 0 0 2 2 2 1 Nitroreductase family TM1586_NiRdase PF14512.6 CAV27093.1 - 0.0017 18.0 0.1 0.43 10.1 0.0 2.6 2 1 1 3 3 3 2 Putative TM nitroreductase DEAD PF00270.29 CAV27095.1 - 5.2e-50 169.6 0.3 9.2e-50 168.8 0.3 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CAV27095.1 - 3.3e-28 98.3 0.1 3.5e-26 91.7 0.0 2.5 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 CAV27095.1 - 3.5e-08 33.6 0.0 7.7e-08 32.5 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_19 PF13245.6 CAV27095.1 - 0.00025 21.4 0.5 0.0017 18.7 0.3 2.2 1 1 0 2 2 2 1 AAA domain AAA_22 PF13401.6 CAV27095.1 - 0.0019 18.5 0.4 0.028 14.7 0.5 2.5 2 1 0 2 2 2 1 AAA domain SNF2_N PF00176.23 CAV27095.1 - 0.0097 14.7 0.0 0.014 14.2 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain PhoH PF02562.16 CAV27095.1 - 0.02 14.3 1.7 0.25 10.8 0.9 2.3 2 1 0 2 2 2 0 PhoH-like protein UvrD-helicase PF00580.21 CAV27095.1 - 0.023 14.2 1.6 0.032 13.7 0.6 1.5 1 1 0 1 1 1 0 UvrD/REP helicase N-terminal domain Flavi_DEAD PF07652.14 CAV27095.1 - 0.052 13.5 0.3 0.15 12.0 0.3 1.9 1 1 0 1 1 1 0 Flavivirus DEAD domain Gemin6 PF06372.12 CAV27095.1 - 0.08 12.5 0.0 0.15 11.6 0.0 1.5 1 0 0 1 1 1 0 Gemin6 protein HECT PF00632.25 CAV27095.1 - 0.19 11.2 0.0 0.32 10.4 0.0 1.3 1 0 0 1 1 1 0 HECT-domain (ubiquitin-transferase) DUF296 PF03479.15 CAV27097.1 - 1.8e-24 86.2 0.4 2.1e-24 86.0 0.4 1.1 1 0 0 1 1 1 1 Plants and Prokaryotes Conserved (PCC) domain DUF2560 PF10834.8 CAV27097.1 - 0.12 12.6 0.0 0.18 12.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2560) RNase_T PF00929.24 CAV27099.1 - 4.8e-28 98.8 0.0 6.4e-28 98.4 0.0 1.1 1 0 0 1 1 1 1 Exonuclease DUF5051 PF16473.5 CAV27099.1 - 3.6e-08 33.5 0.1 8.2e-08 32.4 0.1 1.6 1 1 0 1 1 1 1 3' exoribonuclease, RNase T-like DNA_pol_A_exo1 PF01612.20 CAV27099.1 - 0.057 13.1 0.0 0.12 12.0 0.0 1.7 1 1 0 1 1 1 0 3'-5' exonuclease RNase_H_2 PF13482.6 CAV27099.1 - 0.058 13.4 0.0 0.1 12.6 0.0 1.6 1 1 0 1 1 1 0 RNase_H superfamily LPAM_2 PF13627.6 CAV27101.1 - 0.72 9.8 2.5 1.3 9.0 2.5 1.4 1 0 0 1 1 1 0 Prokaryotic lipoprotein-attachment site Hydrolase_3 PF08282.12 CAV27101.1 - 0.8 9.4 11.4 0.11 12.3 2.2 2.1 1 1 1 2 2 2 0 haloacid dehalogenase-like hydrolase DEAD PF00270.29 CAV27104.1 - 5.1e-47 159.9 0.0 1.7e-46 158.2 0.0 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CAV27104.1 - 6.1e-29 100.6 0.1 4.5e-27 94.6 0.0 2.5 3 0 0 3 3 3 1 Helicase conserved C-terminal domain DbpA PF03880.15 CAV27104.1 - 5.9e-21 74.3 1.4 1.4e-20 73.1 1.4 1.7 1 0 0 1 1 1 1 DbpA RNA binding domain ResIII PF04851.15 CAV27104.1 - 2.9e-06 27.4 0.0 6e-06 26.4 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_30 PF13604.6 CAV27104.1 - 0.0017 18.1 0.0 0.0026 17.5 0.0 1.4 1 0 0 1 1 1 1 AAA domain CMS1 PF14617.6 CAV27104.1 - 0.015 14.6 0.0 0.031 13.6 0.0 1.4 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit UvrA_inter PF17760.1 CAV27104.1 - 0.1 12.7 0.5 0.23 11.6 0.1 1.7 2 0 0 2 2 2 0 UvrA interaction domain Aldo_ket_red PF00248.21 CAV27106.1 - 8.7e-49 166.3 0.0 1.6e-48 165.4 0.0 1.3 1 1 0 1 1 1 1 Aldo/keto reductase family GTP-bdg_N PF13167.6 CAV27106.1 - 0.066 13.9 0.0 0.18 12.5 0.0 1.7 1 0 0 1 1 1 0 GTP-binding GTPase N-terminal zf-UBP PF02148.19 CAV27106.1 - 0.16 12.3 0.1 3 8.2 0.2 2.2 2 0 0 2 2 2 0 Zn-finger in ubiquitin-hydrolases and other protein LRR_3 PF07725.12 CAV27108.1 - 0.077 12.9 0.3 0.47 10.4 0.1 2.5 2 0 0 2 2 2 0 Leucine Rich Repeat HTH_6 PF01418.17 CAV27108.1 - 0.19 11.8 0.2 0.38 10.8 0.2 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain, rpiR family Peptidase_M3 PF01432.20 CAV27110.1 - 1.5e-19 70.6 0.1 4.7e-15 55.8 0.0 2.3 2 0 0 2 2 2 2 Peptidase family M3 Sugarporin_N PF11471.8 CAV27113.1 - 0.29 11.1 0.6 0.53 10.3 0.6 1.4 1 0 0 1 1 1 0 Maltoporin periplasmic N-terminal extension DUF3187 PF11383.8 CAV27114.1 - 2.9e-125 417.8 6.0 3.3e-125 417.6 6.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3187) GerE PF00196.19 CAV27116.1 - 1.3e-12 47.0 0.1 2.2e-12 46.3 0.1 1.4 1 0 0 1 1 1 1 Bacterial regulatory proteins, luxR family Sigma70_r4_2 PF08281.12 CAV27116.1 - 7.1e-07 28.8 0.3 1.3e-06 27.9 0.3 1.4 1 0 0 1 1 1 1 Sigma-70, region 4 Sigma70_ECF PF07638.11 CAV27116.1 - 0.00055 19.9 0.0 0.00076 19.4 0.0 1.2 1 0 0 1 1 1 1 ECF sigma factor HTH_28 PF13518.6 CAV27116.1 - 0.0012 19.0 0.1 0.0077 16.3 0.0 2.2 2 0 0 2 2 2 1 Helix-turn-helix domain Dimer_Tnp_hAT PF05699.14 CAV27116.1 - 0.0031 17.3 0.4 3.1 7.7 0.0 2.5 2 0 0 2 2 2 2 hAT family C-terminal dimerisation region HTH_40 PF14493.6 CAV27116.1 - 0.025 15.0 0.0 0.057 13.9 0.0 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_23 PF13384.6 CAV27116.1 - 0.036 13.9 0.2 0.15 11.9 0.1 2.0 2 0 0 2 2 2 0 Homeodomain-like domain RecX PF02631.16 CAV27118.1 - 4.9e-30 104.5 5.6 8.8e-18 64.9 0.3 2.2 2 0 0 2 2 2 2 RecX family HTH_57 PF18679.1 CAV27118.1 - 0.01 16.1 3.6 2.1 8.7 0.8 3.1 2 1 1 3 3 3 0 ThcOx helix turn helix domain DUF494 PF04361.13 CAV27118.1 - 0.03 14.2 0.7 12 5.8 0.0 3.2 2 1 2 4 4 4 0 Protein of unknown function (DUF494) Pex14_N PF04695.13 CAV27118.1 - 0.043 14.5 5.8 6.3 7.4 0.1 3.1 2 1 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF4250 PF14056.6 CAV27118.1 - 0.054 13.4 0.2 1.2 9.2 0.0 3.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4250) Raf1_HTH PF18579.1 CAV27118.1 - 0.064 13.0 0.0 48 3.7 0.0 3.9 3 1 0 3 3 3 0 Rubisco accumulation factor 1 helix turn helix domain PepSY_2 PF13670.6 CAV27118.1 - 0.11 12.5 0.4 5 7.2 0.0 2.9 3 0 0 3 3 3 0 Peptidase propeptide and YPEB domain Ribosomal_S13_N PF08069.12 CAV27118.1 - 0.13 12.3 0.6 18 5.5 0.1 3.2 3 0 0 3 3 3 0 Ribosomal S13/S15 N-terminal domain ANAPC2 PF08672.11 CAV27118.1 - 0.14 12.7 1.2 29 5.3 0.0 3.0 3 0 0 3 3 3 0 Anaphase promoting complex (APC) subunit 2 MerR_1 PF13411.6 CAV27118.1 - 0.3 11.2 2.0 3 8.0 0.1 3.1 4 0 0 4 4 4 0 MerR HTH family regulatory protein MS_channel PF00924.18 CAV27120.1 - 3e-54 183.7 2.2 5.1e-54 182.9 2.2 1.3 1 0 0 1 1 1 1 Mechanosensitive ion channel TM_helix PF05552.12 CAV27120.1 - 0.0056 16.6 0.8 0.015 15.2 0.0 2.1 2 0 0 2 2 2 1 Conserved TM helix Na_H_antiport_2 PF13726.6 CAV27120.1 - 0.66 10.2 6.0 0.48 10.6 3.6 2.1 2 0 0 2 2 2 0 Na+-H+ antiporter family DsbC PF11412.8 CAV27126.1 - 2.9e-15 56.4 0.0 6e-15 55.4 0.0 1.5 1 0 0 1 1 1 1 Disulphide bond corrector protein DsbC Thioredoxin_7 PF13899.6 CAV27126.1 - 3.5e-10 39.9 0.0 6.6e-10 39.0 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin-like Thioredoxin PF00085.20 CAV27126.1 - 0.048 13.7 0.1 0.1 12.6 0.1 1.5 1 0 0 1 1 1 0 Thioredoxin Bac_rhamnosid_N PF08531.10 CAV27126.1 - 0.15 11.8 0.1 2 8.2 0.0 2.5 2 1 1 3 3 3 0 Alpha-L-rhamnosidase N-terminal domain Redoxin PF08534.10 CAV27129.1 - 4e-15 55.8 0.0 5.2e-15 55.4 0.0 1.1 1 0 0 1 1 1 1 Redoxin AhpC-TSA PF00578.21 CAV27129.1 - 1.2e-14 54.3 0.0 1.4e-14 54.0 0.0 1.1 1 0 0 1 1 1 1 AhpC/TSA family Thioredoxin_8 PF13905.6 CAV27129.1 - 8.8e-11 42.0 0.0 1.2e-10 41.5 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin-like Thioredoxin PF00085.20 CAV27129.1 - 2.4e-10 40.3 0.0 1.5e-07 31.3 0.0 2.1 2 0 0 2 2 2 2 Thioredoxin Thioredoxin_2 PF13098.6 CAV27129.1 - 2.2e-07 31.3 0.0 4.9e-07 30.2 0.0 1.6 1 1 0 1 1 1 1 Thioredoxin-like domain TraF PF13728.6 CAV27129.1 - 0.00021 21.2 0.0 0.00041 20.2 0.0 1.5 1 1 0 1 1 1 1 F plasmid transfer operon protein Thioredoxin_7 PF13899.6 CAV27129.1 - 0.0042 17.2 0.1 0.0063 16.7 0.1 1.4 1 1 0 1 1 1 1 Thioredoxin-like Thioredoxin_4 PF13462.6 CAV27131.1 - 6.6e-21 75.2 0.2 1.5e-20 74.0 0.0 1.6 2 0 0 2 2 2 1 Thioredoxin DSBA PF01323.20 CAV27131.1 - 4.6e-14 52.7 0.2 2.4e-11 43.8 0.2 2.4 1 1 0 1 1 1 1 DSBA-like thioredoxin domain Thioredoxin_2 PF13098.6 CAV27131.1 - 3.5e-12 46.7 0.1 3.2e-11 43.7 0.2 2.3 2 1 0 2 2 2 1 Thioredoxin-like domain Thioredoxin PF00085.20 CAV27131.1 - 0.003 17.5 0.0 0.02 14.9 0.0 2.1 2 0 0 2 2 2 1 Thioredoxin Thioredoxin_3 PF13192.6 CAV27131.1 - 0.012 15.6 0.1 5.3 7.2 0.0 2.7 2 1 0 2 2 2 0 Thioredoxin domain Thioredoxin_8 PF13905.6 CAV27131.1 - 0.027 14.8 0.2 0.13 12.6 0.1 2.1 3 0 0 3 3 3 0 Thioredoxin-like ImcF-related_N PF14331.6 CAV27131.1 - 0.032 13.6 0.0 0.087 12.2 0.0 1.6 2 0 0 2 2 2 0 ImcF-related N-terminal domain AhpC-TSA PF00578.21 CAV27131.1 - 0.071 13.0 0.1 0.16 11.9 0.0 1.7 1 1 0 1 1 1 0 AhpC/TSA family DUF411 PF04214.13 CAV27131.1 - 0.082 12.8 0.0 5.5 7.0 0.0 2.6 2 1 0 2 2 2 0 Protein of unknown function, DUF DUF836 PF05768.14 CAV27131.1 - 0.091 13.2 0.1 0.21 12.0 0.1 1.6 1 1 0 1 1 1 0 Glutaredoxin-like domain (DUF836) HD PF01966.22 CAV27133.1 - 4.9e-29 101.0 0.0 1.3e-18 67.3 0.0 2.3 2 0 0 2 2 2 2 HD domain HD_5 PF13487.6 CAV27133.1 - 5.8e-12 45.7 0.0 4.1e-10 39.8 0.0 2.5 2 0 0 2 2 2 1 HD domain HDOD PF08668.12 CAV27133.1 - 1.1e-08 34.8 0.1 1.8e-05 24.3 0.0 2.4 2 0 0 2 2 2 2 HDOD domain CBM_14 PF01607.24 CAV27133.1 - 0.12 12.6 0.2 0.37 11.0 0.1 1.9 2 0 0 2 2 2 0 Chitin binding Peritrophin-A domain Acetyltransf_3 PF13302.7 CAV27134.1 - 2.9e-21 76.6 0.1 3.6e-21 76.3 0.1 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 CAV27134.1 - 3.3e-11 43.4 0.0 4.7e-11 43.0 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_4 PF13420.7 CAV27134.1 - 2.4e-08 34.3 0.5 2.8e-08 34.0 0.5 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.6 CAV27134.1 - 0.008 15.9 0.0 0.011 15.4 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Intimin_C PF07979.11 CAV27134.1 - 0.08 13.4 1.0 1 9.8 0.1 2.3 1 1 1 2 2 2 0 Intimin C-type lectin domain HATPase_c PF02518.26 CAV27136.1 - 1.6e-14 54.3 0.0 3.3e-14 53.3 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 CAV27136.1 - 1.5e-07 31.3 0.2 3.5e-07 30.1 0.2 1.5 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain HATPase_c_3 PF13589.6 CAV27136.1 - 0.04 13.7 0.0 0.072 12.9 0.0 1.3 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DUF2532 PF10811.8 CAV27136.1 - 0.068 13.2 0.1 0.27 11.3 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2532) HAMP PF00672.25 CAV27136.1 - 0.11 12.9 0.1 0.36 11.3 0.0 1.9 2 0 0 2 2 2 0 HAMP domain Response_reg PF00072.24 CAV27138.1 - 1.2e-22 80.2 0.0 2.1e-22 79.4 0.0 1.4 1 0 0 1 1 1 1 Response regulator receiver domain Trans_reg_C PF00486.28 CAV27138.1 - 8.4e-18 64.2 0.0 1.4e-17 63.5 0.0 1.4 1 0 0 1 1 1 1 Transcriptional regulatory protein, C terminal Gliadin PF13016.6 CAV27138.1 - 0.034 14.6 0.9 0.044 14.2 0.0 1.6 2 0 0 2 2 2 0 Cys-rich Gliadin N-terminal EAL PF00563.20 CAV27142.1 - 4.5e-63 213.0 0.0 6.9e-63 212.3 0.0 1.3 1 0 0 1 1 1 1 EAL domain GGDEF PF00990.21 CAV27142.1 - 1e-40 139.1 0.0 7.1e-40 136.4 0.0 2.3 3 0 0 3 3 3 1 Diguanylate cyclase, GGDEF domain PAS_8 PF13188.7 CAV27142.1 - 0.00018 21.5 0.0 0.017 15.1 0.0 2.9 2 0 0 2 2 2 1 PAS domain Il2rg PF15874.5 CAV27142.1 - 0.049 13.9 0.4 5 7.5 0.3 2.6 2 0 0 2 2 2 0 Putative Interleukin 2 receptor, gamma chain EAL PF00563.20 CAV27145.1 - 5.8e-31 107.8 0.0 1.2e-30 106.8 0.0 1.5 1 0 0 1 1 1 1 EAL domain GntR PF00392.21 CAV27147.1 - 5e-15 54.9 0.1 5.6e-14 51.5 0.1 2.1 2 0 0 2 2 2 1 Bacterial regulatory proteins, gntR family Rrf2 PF02082.20 CAV27147.1 - 0.0001 22.6 0.6 0.0079 16.5 0.1 2.2 1 1 1 2 2 2 1 Transcriptional regulator Fe_dep_repress PF01325.19 CAV27147.1 - 0.0016 18.6 0.3 0.48 10.7 0.0 2.2 2 0 0 2 2 2 2 Iron dependent repressor, N-terminal DNA binding domain TrmB PF01978.19 CAV27147.1 - 0.008 16.0 0.1 0.094 12.6 0.1 2.1 2 0 0 2 2 2 1 Sugar-specific transcriptional regulator TrmB Mnd1 PF03962.15 CAV27147.1 - 0.0085 16.4 0.6 4.9 7.5 0.1 2.3 2 0 0 2 2 2 2 Mnd1 HTH domain Glyco_hydro_77 PF02446.17 CAV27147.1 - 0.014 14.3 0.0 0.016 14.1 0.0 1.1 1 0 0 1 1 1 0 4-alpha-glucanotransferase MarR_2 PF12802.7 CAV27147.1 - 0.023 14.6 0.1 0.24 11.3 0.0 2.0 2 0 0 2 2 2 0 MarR family DUF2250 PF10007.9 CAV27147.1 - 0.11 12.6 1.0 0.84 9.8 0.2 2.0 1 1 1 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2250) ABC_tran PF00005.27 CAV27149.1 - 1.5e-24 87.1 0.2 2.5e-24 86.3 0.2 1.4 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 CAV27149.1 - 3.7e-06 27.0 6.0 0.0008 19.3 0.4 2.1 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system RsgA_GTPase PF03193.16 CAV27149.1 - 5.5e-05 23.1 0.1 0.00017 21.5 0.1 1.8 1 0 0 1 1 1 1 RsgA GTPase SMC_N PF02463.19 CAV27149.1 - 0.00076 19.0 0.4 0.0019 17.7 0.4 1.6 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 CAV27149.1 - 0.0046 16.7 0.1 0.0095 15.7 0.1 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_23 PF13476.6 CAV27149.1 - 0.0047 17.4 1.1 0.012 16.1 1.1 1.9 1 1 0 1 1 1 1 AAA domain MMR_HSR1 PF01926.23 CAV27149.1 - 0.011 15.8 0.5 0.021 14.9 0.5 1.9 1 1 0 1 1 1 0 50S ribosome-binding GTPase AAA_30 PF13604.6 CAV27149.1 - 0.012 15.3 0.0 0.033 13.9 0.0 1.6 1 1 0 1 1 1 0 AAA domain TsaE PF02367.17 CAV27149.1 - 0.031 14.3 0.1 0.071 13.1 0.0 1.7 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE RadC PF04002.15 CAV27149.1 - 0.063 13.2 0.0 0.14 12.1 0.0 1.6 1 0 0 1 1 1 0 RadC-like JAB domain AAA_22 PF13401.6 CAV27149.1 - 0.074 13.3 1.0 0.26 11.6 1.0 1.9 1 1 0 1 1 1 0 AAA domain MeaB PF03308.16 CAV27149.1 - 0.12 11.3 0.1 0.2 10.6 0.1 1.3 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_33 PF13671.6 CAV27149.1 - 0.21 11.7 0.5 0.46 10.6 0.3 1.5 1 1 0 1 1 1 0 AAA domain DUF3658 PF12395.8 CAV27152.1 - 0.16 11.9 0.0 0.22 11.4 0.0 1.3 1 1 0 1 1 1 0 Protein of unknown function ABM PF03992.16 CAV27154.1 - 9.1e-11 41.7 0.1 1e-10 41.6 0.1 1.1 1 0 0 1 1 1 1 Antibiotic biosynthesis monooxygenase DNA_repr_REX1B PF14966.6 CAV27154.1 - 0.036 14.7 0.4 0.052 14.2 0.4 1.2 1 0 0 1 1 1 0 DNA repair REX1-B ACT_7 PF13840.6 CAV27154.1 - 0.041 13.7 0.0 0.14 11.9 0.0 1.7 2 0 0 2 2 2 0 ACT domain PUA_3 PF17785.1 CAV27154.1 - 0.072 12.9 0.0 0.12 12.2 0.0 1.3 1 0 0 1 1 1 0 PUA-like domain NTP_transf_6 PF06042.11 CAV27156.1 - 3.5e-65 218.7 0.0 4e-65 218.5 0.0 1.0 1 0 0 1 1 1 1 Nucleotidyltransferase DUF4823 PF16105.5 CAV27158.1 - 2.4e-56 189.5 0.0 2.9e-56 189.3 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4823) dCMP_cyt_deam_1 PF00383.23 CAV27160.1 - 4e-18 65.1 0.5 5.1e-18 64.8 0.5 1.1 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 CAV27160.1 - 2.2e-13 50.2 0.0 2.5e-13 49.9 0.0 1.1 1 0 0 1 1 1 1 MafB19-like deaminase Inv-AAD PF18785.1 CAV27160.1 - 6.2e-05 22.9 0.5 0.00062 19.6 0.5 2.0 1 1 0 1 1 1 1 Invertebrate-AID/APOBEC-deaminase APOBEC_N PF08210.11 CAV27160.1 - 0.006 16.5 0.0 0.008 16.1 0.0 1.3 1 1 0 1 1 1 1 APOBEC-like N-terminal domain NAD1 PF18778.1 CAV27160.1 - 0.009 16.1 0.0 0.013 15.6 0.0 1.3 1 1 0 1 1 1 1 Novel AID APOBEC clade 1 SNAD4 PF18750.1 CAV27160.1 - 0.035 14.2 0.0 0.052 13.7 0.0 1.4 1 1 0 1 1 1 0 Secreted Novel AID/APOBEC-like Deaminase 4 NUDIX PF00293.28 CAV27162.1 - 2.6e-17 63.1 0.2 3.3e-17 62.7 0.2 1.1 1 0 0 1 1 1 1 NUDIX domain PseudoU_synth_2 PF00849.22 CAV27163.1 - 3.5e-30 105.2 0.1 3.5e-30 105.2 0.1 2.7 3 0 0 3 3 3 1 RNA pseudouridylate synthase YolD PF08863.10 CAV27163.1 - 0.08 13.0 3.2 0.37 10.9 1.9 2.5 1 1 1 2 2 2 0 YolD-like protein FapA PF03961.13 CAV27163.1 - 6.4 5.3 8.6 9.7 4.7 8.6 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A NYD-SP28 PF14772.6 CAV27163.1 - 7 6.8 19.1 0.47 10.5 7.5 2.8 1 1 1 2 2 2 0 Sperm tail MFS_1 PF07690.16 CAV27169.1 - 1.6e-39 135.9 37.2 1.6e-39 135.9 37.2 1.4 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CAV27169.1 - 2.1e-14 53.2 8.5 2.1e-14 53.2 8.5 2.5 2 1 1 3 3 3 1 Sugar (and other) transporter MFS_2 PF13347.6 CAV27169.1 - 4.5e-08 32.1 32.1 0.0008 18.1 6.7 2.5 1 1 1 2 2 2 2 MFS/sugar transport protein CTV_P6 PF06706.11 CAV27169.1 - 8.2 6.2 9.3 8.4 6.2 0.8 3.8 3 1 0 3 3 3 0 Citrus tristeza virus 6-kDa protein Hydrolase_4 PF12146.8 CAV27172.1 - 7.2e-10 38.5 0.0 4.1e-08 32.8 0.0 2.1 2 0 0 2 2 2 1 Serine aminopeptidase, S33 PAF-AH_p_II PF03403.13 CAV27172.1 - 1.2e-07 30.6 0.0 0.00013 20.6 0.0 2.2 1 1 1 2 2 2 2 Platelet-activating factor acetylhydrolase, isoform II Chlorophyllase2 PF12740.7 CAV27172.1 - 5.5e-07 28.8 0.0 8e-07 28.2 0.0 1.2 1 0 0 1 1 1 1 Chlorophyllase enzyme Abhydrolase_6 PF12697.7 CAV27172.1 - 5.7e-07 30.4 0.0 3e-06 28.0 0.0 1.9 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 CAV27172.1 - 2.7e-06 27.2 0.0 0.0003 20.5 0.0 2.2 2 0 0 2 2 2 1 alpha/beta hydrolase fold DLH PF01738.18 CAV27172.1 - 1.3e-05 24.9 0.0 7.7e-05 22.3 0.0 1.9 1 1 0 1 1 1 1 Dienelactone hydrolase family Chlorophyllase PF07224.11 CAV27172.1 - 2.4e-05 23.5 0.0 3.8e-05 22.8 0.0 1.3 1 0 0 1 1 1 1 Chlorophyllase Peptidase_S9 PF00326.21 CAV27172.1 - 2.7e-05 23.8 0.0 4.6e-05 23.0 0.0 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family Peptidase_S15 PF02129.18 CAV27172.1 - 0.00024 20.8 0.2 0.00039 20.1 0.2 1.3 1 0 0 1 1 1 1 X-Pro dipeptidyl-peptidase (S15 family) Abhydrolase_3 PF07859.13 CAV27172.1 - 0.053 13.4 0.0 0.084 12.7 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold HTH_18 PF12833.7 CAV27175.1 - 7.4e-19 67.8 0.0 1.2e-18 67.2 0.0 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 CAV27175.1 - 9.7e-08 31.9 0.1 5.4e-07 29.6 0.2 2.1 2 0 0 2 2 2 1 Bacterial regulatory helix-turn-helix proteins, AraC family DUF2304 PF10066.9 CAV27175.1 - 4 7.7 8.6 5.9 7.2 3.1 2.6 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2304) Na_H_antiporter PF03553.14 CAV27178.1 - 2.9e-16 59.6 37.9 2.4e-13 50.0 21.3 2.4 1 1 1 2 2 2 2 Na+/H+ antiporter family CitMHS PF03600.16 CAV27178.1 - 0.0076 15.5 40.6 0.35 10.0 9.0 2.4 1 1 1 2 2 2 2 Citrate transporter FAA_hydrolase PF01557.18 CAV27181.1 - 0.00041 20.1 0.0 0.00053 19.7 0.0 1.1 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family Lactamase_B_2 PF12706.7 CAV27184.1 - 1.3e-43 148.8 0.1 1.9e-43 148.3 0.1 1.2 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 CAV27184.1 - 1.4e-14 54.3 0.0 2.1e-14 53.8 0.0 1.2 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B PF00753.27 CAV27184.1 - 0.00022 21.3 3.2 0.0057 16.7 3.2 2.5 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily SgrR_N PF12793.7 CAV27187.1 - 4.1e-37 126.9 0.4 8.9e-37 125.8 0.4 1.6 1 0 0 1 1 1 1 Sugar transport-related sRNA regulator N-term SBP_bac_5 PF00496.22 CAV27187.1 - 2.4e-24 86.0 0.0 1.3e-23 83.6 0.0 1.9 1 1 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 5 Middle DUF910 PF06014.11 CAV27187.1 - 0.13 12.3 0.0 0.6 10.1 0.0 2.0 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF910) RimK PF08443.11 CAV27192.1 - 2.7e-68 229.3 0.3 3.5e-68 228.9 0.3 1.1 1 0 0 1 1 1 1 RimK-like ATP-grasp domain Rimk_N PF18030.1 CAV27192.1 - 2.5e-44 149.6 0.0 4.2e-44 148.9 0.0 1.4 1 0 0 1 1 1 1 RimK PreATP-grasp domain GSH-S_ATP PF02955.16 CAV27192.1 - 6.5e-20 71.3 0.6 1e-19 70.6 0.6 1.3 1 0 0 1 1 1 1 Prokaryotic glutathione synthetase, ATP-grasp domain ATP-grasp_3 PF02655.14 CAV27192.1 - 1.8e-10 41.1 0.1 3.5e-10 40.2 0.1 1.4 1 0 0 1 1 1 1 ATP-grasp domain ATPgrasp_ST PF14397.6 CAV27192.1 - 1.7e-08 34.1 0.7 0.0032 16.8 0.0 3.1 1 1 1 2 2 2 2 Sugar-transfer associated ATP-grasp Dala_Dala_lig_C PF07478.13 CAV27192.1 - 5.3e-06 26.1 0.3 4.6e-05 23.0 0.3 2.0 1 1 0 1 1 1 1 D-ala D-ala ligase C-terminus ATPgrasp_YheCD PF14398.6 CAV27192.1 - 2.4e-05 23.7 0.2 0.019 14.2 0.1 3.1 1 1 1 2 2 2 1 YheC/D like ATP-grasp Synapsin_C PF02750.14 CAV27192.1 - 0.00082 18.9 0.0 0.0014 18.2 0.0 1.3 1 0 0 1 1 1 1 Synapsin, ATP binding domain GARS_A PF01071.19 CAV27192.1 - 0.0089 15.8 0.2 0.017 14.9 0.2 1.6 1 1 0 1 1 1 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain R2K_3 PF14243.6 CAV27192.1 - 0.0091 16.0 0.0 0.014 15.4 0.0 1.3 1 0 0 1 1 1 1 ATP-grasp domain, R2K clade family 3 ATP-grasp_2 PF08442.10 CAV27192.1 - 0.024 14.2 0.5 0.045 13.3 0.1 1.6 2 0 0 2 2 2 0 ATP-grasp domain ATP-grasp PF02222.22 CAV27192.1 - 0.034 13.7 0.0 0.15 11.6 0.0 1.9 2 0 0 2 2 2 0 ATP-grasp domain TTL PF03133.15 CAV27192.1 - 0.19 10.8 0.0 1.3 8.1 0.0 2.2 3 0 0 3 3 3 0 Tubulin-tyrosine ligase family Zn_protease PF05618.11 CAV27195.1 - 1.6e-29 102.5 0.0 1.8e-29 102.4 0.0 1.0 1 0 0 1 1 1 1 Putative ATP-dependant zinc protease gag-asp_proteas PF13975.6 CAV27195.1 - 0.11 13.1 0.1 21 5.8 0.0 2.2 2 0 0 2 2 2 0 gag-polyprotein putative aspartyl protease Lactamase_B PF00753.27 CAV27198.1 - 4.5e-14 52.9 2.1 1.2e-13 51.5 2.1 1.6 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 CAV27198.1 - 0.0012 18.4 0.7 0.0044 16.5 0.5 2.0 2 0 0 2 2 2 1 Beta-lactamase superfamily domain 2OG-FeII_Oxy_3 PF13640.6 CAV27200.1 - 1.3e-21 77.2 0.0 1.9e-21 76.7 0.0 1.2 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_4 PF13661.6 CAV27200.1 - 3.1e-17 63.0 0.1 1.2e-16 61.2 0.0 1.8 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy PF03171.20 CAV27200.1 - 3.7e-05 24.1 0.0 6.2e-05 23.4 0.0 1.3 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_5 PF13759.6 CAV27200.1 - 0.063 13.7 0.0 0.12 12.8 0.0 1.6 1 1 0 1 1 1 0 Putative 2OG-Fe(II) oxygenase SBP_bac_8 PF13416.6 CAV27203.1 - 3.5e-34 118.9 11.7 4.5e-34 118.5 11.7 1.1 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_1 PF01547.25 CAV27203.1 - 5.6e-25 88.9 10.8 7.6e-25 88.5 10.8 1.2 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_6 PF13343.6 CAV27203.1 - 1.8e-05 24.3 0.1 0.18 11.2 0.0 2.4 2 0 0 2 2 2 2 Bacterial extracellular solute-binding protein BPD_transp_1 PF00528.22 CAV27207.1 - 9e-13 48.4 8.7 9e-13 48.4 8.7 2.4 2 1 0 2 2 2 2 Binding-protein-dependent transport system inner membrane component BPD_transp_1 PF00528.22 CAV27209.1 - 4.1e-16 59.2 18.3 4.1e-16 59.2 18.3 2.1 1 1 0 2 2 2 1 Binding-protein-dependent transport system inner membrane component ABC_tran PF00005.27 CAV27212.1 - 8.4e-31 107.3 0.0 1.3e-30 106.7 0.0 1.3 1 0 0 1 1 1 1 ABC transporter OB_MalK PF17912.1 CAV27212.1 - 6.9e-11 42.8 0.0 3e-10 40.8 0.0 2.2 1 0 0 1 1 1 1 MalK OB fold domain CysA_C_terminal PF17850.1 CAV27212.1 - 4e-08 33.7 0.0 1.3e-07 32.1 0.0 1.9 1 0 0 1 1 1 1 CysA C-terminal regulatory domain AAA_21 PF13304.6 CAV27212.1 - 5.7e-08 32.9 0.2 0.0055 16.6 0.1 2.2 1 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 CAV27212.1 - 1.4e-05 24.6 0.3 0.00016 21.2 0.3 2.1 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain RsgA_GTPase PF03193.16 CAV27212.1 - 0.00011 22.2 0.1 0.00023 21.1 0.1 1.5 1 0 0 1 1 1 1 RsgA GTPase AAA_16 PF13191.6 CAV27212.1 - 0.00097 19.6 0.1 0.0015 18.9 0.1 1.4 1 1 0 1 1 1 1 AAA ATPase domain Rad17 PF03215.15 CAV27212.1 - 0.0023 17.9 0.0 0.0036 17.2 0.0 1.3 1 0 0 1 1 1 1 Rad17 P-loop domain AAA_15 PF13175.6 CAV27212.1 - 0.0027 17.5 0.0 0.0046 16.7 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain AAA_29 PF13555.6 CAV27212.1 - 0.0052 16.5 0.1 0.011 15.4 0.1 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA PF00004.29 CAV27212.1 - 0.019 15.4 0.0 0.04 14.3 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 CAV27212.1 - 0.024 14.9 0.1 0.052 13.8 0.1 1.7 1 1 0 1 1 1 0 AAA domain AAA_23 PF13476.6 CAV27212.1 - 0.026 15.0 0.1 0.067 13.7 0.0 1.6 1 1 0 1 1 1 0 AAA domain AAA_25 PF13481.6 CAV27212.1 - 0.04 13.5 0.0 0.22 11.1 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_5 PF07728.14 CAV27212.1 - 0.068 13.2 0.1 0.14 12.1 0.1 1.5 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) TOBE_2 PF08402.10 CAV27212.1 - 0.093 12.9 0.0 0.22 11.7 0.0 1.7 1 0 0 1 1 1 0 TOBE domain GDPD PF03009.17 CAV27213.1 - 7.6e-40 137.3 0.7 9e-40 137.0 0.7 1.1 1 0 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family PI-PLC-X PF00388.19 CAV27213.1 - 0.017 14.7 0.0 0.04 13.5 0.0 1.5 1 0 0 1 1 1 0 Phosphatidylinositol-specific phospholipase C, X domain TauE PF01925.19 CAV27215.1 - 1.9e-23 83.4 26.2 2.2e-23 83.2 26.2 1.0 1 0 0 1 1 1 1 Sulfite exporter TauE/SafE YkuD PF03734.14 CAV27216.1 - 2.9e-18 66.7 0.0 4.4e-18 66.1 0.0 1.2 1 0 0 1 1 1 1 L,D-transpeptidase catalytic domain Pribosyltran PF00156.27 CAV27216.1 - 0.014 14.9 0.7 0.027 14.0 0.7 1.4 1 0 0 1 1 1 0 Phosphoribosyl transferase domain Acetyltransf_1 PF00583.25 CAV27218.1 - 1.3e-12 48.0 0.0 1.5e-12 47.7 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 CAV27218.1 - 3.2e-10 40.0 0.1 4.5e-10 39.5 0.1 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 CAV27218.1 - 5.5e-10 39.5 0.1 8.7e-10 38.9 0.1 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 CAV27218.1 - 0.0053 16.7 0.1 0.008 16.1 0.1 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_4 PF13420.7 CAV27218.1 - 0.0076 16.4 0.1 0.0083 16.3 0.1 1.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain DUF4007 PF13182.6 CAV27218.1 - 0.019 14.1 0.2 0.026 13.6 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4007) Acetyltransf_CG PF14542.6 CAV27218.1 - 0.021 14.9 0.0 0.032 14.4 0.0 1.3 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase DUF3611 PF12263.8 CAV27218.1 - 0.056 13.4 0.1 0.078 12.9 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3611) Acetyltransf_18 PF18014.1 CAV27218.1 - 0.058 13.2 0.1 0.14 12.0 0.1 1.7 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain Glyco_transf_25 PF01755.17 CAV27221.1 - 1.9e-29 103.0 0.7 4.3e-29 101.8 0.7 1.5 1 1 0 1 1 1 1 Glycosyltransferase family 25 (LPS biosynthesis protein) RPW8 PF05659.11 CAV27221.1 - 0.053 13.2 0.0 0.13 11.9 0.0 1.6 1 0 0 1 1 1 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 GFO_IDH_MocA PF01408.22 CAV27222.1 - 3.1e-29 102.2 0.8 5.9e-29 101.3 0.8 1.5 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold NAD_binding_3 PF03447.16 CAV27222.1 - 0.0045 17.6 1.6 0.0055 17.4 0.3 1.7 2 0 0 2 2 2 1 Homoserine dehydrogenase, NAD binding domain DUF2150 PF09920.9 CAV27222.1 - 0.0056 16.7 1.6 0.42 10.6 0.1 2.3 2 0 0 2 2 2 2 Uncharacterized protein conserved in archaea (DUF2150) Glutaredoxin2_C PF04399.13 CAV27226.1 - 1.6e-28 99.1 0.0 2.2e-28 98.7 0.0 1.2 1 0 0 1 1 1 1 Glutaredoxin 2, C terminal domain GST_N_3 PF13417.6 CAV27226.1 - 3.4e-14 53.0 0.0 1.6e-13 50.8 0.0 1.9 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 CAV27226.1 - 8.5e-08 32.4 0.0 2.1e-07 31.1 0.0 1.7 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain Glutaredoxin PF00462.24 CAV27226.1 - 4.1e-05 23.7 0.0 8.7e-05 22.7 0.0 1.6 1 0 0 1 1 1 1 Glutaredoxin GST_N PF02798.20 CAV27226.1 - 0.00021 21.5 0.0 0.00061 20.1 0.0 1.8 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain Kinase-PPPase PF03618.14 CAV27227.1 - 2.9e-72 243.5 0.0 3.2e-72 243.4 0.0 1.0 1 0 0 1 1 1 1 Kinase/pyrophosphorylase PPDK_N PF01326.19 CAV27229.1 - 1.5e-119 399.1 0.2 2.1e-119 398.6 0.2 1.2 1 0 0 1 1 1 1 Pyruvate phosphate dikinase, PEP/pyruvate binding domain PEP-utilizers_C PF02896.18 CAV27229.1 - 2.9e-63 213.7 0.0 6.1e-63 212.7 0.0 1.5 1 0 0 1 1 1 1 PEP-utilising enzyme, TIM barrel domain PEP-utilizers PF00391.23 CAV27229.1 - 2.5e-27 94.4 0.7 5.4e-27 93.3 0.7 1.6 1 0 0 1 1 1 1 PEP-utilising enzyme, mobile domain Polysacc_deac_2 PF04748.13 CAV27229.1 - 0.042 13.0 0.0 0.08 12.1 0.0 1.4 1 0 0 1 1 1 0 Divergent polysaccharide deacetylase MatE PF01554.18 CAV27231.1 - 4e-39 133.9 38.6 2e-20 73.1 15.2 2.2 2 0 0 2 2 2 2 MatE Polysacc_synt_C PF14667.6 CAV27231.1 - 0.00012 22.2 8.0 0.00012 22.2 8.0 4.6 1 1 3 5 5 5 1 Polysaccharide biosynthesis C-terminal domain PAS_6 PF08348.11 CAV27233.1 - 3.7e-35 120.2 0.0 7.6e-35 119.2 0.0 1.5 2 0 0 2 2 2 1 YheO-like PAS domain HTH_22 PF13309.6 CAV27233.1 - 3.6e-13 49.4 0.0 5.9e-13 48.7 0.0 1.3 1 0 0 1 1 1 1 HTH domain LZ_Tnp_IS481 PF13011.6 CAV27233.1 - 0.0005 20.5 0.0 0.00084 19.8 0.0 1.4 1 0 0 1 1 1 1 leucine-zipper of insertion element IS481 HTH_23 PF13384.6 CAV27233.1 - 0.0017 18.1 0.0 0.0028 17.4 0.0 1.3 1 0 0 1 1 1 1 Homeodomain-like domain HTH_17 PF12728.7 CAV27233.1 - 0.0053 16.9 0.0 0.0094 16.1 0.0 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_28 PF13518.6 CAV27233.1 - 0.0075 16.4 0.0 0.013 15.6 0.0 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_29 PF13551.6 CAV27233.1 - 0.016 15.2 0.0 0.028 14.4 0.0 1.4 1 0 0 1 1 1 0 Winged helix-turn helix TrmB PF01978.19 CAV27233.1 - 0.058 13.3 0.0 0.15 12.0 0.0 1.6 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB HTH_10 PF04967.12 CAV27233.1 - 0.061 13.1 0.0 0.13 12.1 0.0 1.6 1 0 0 1 1 1 0 HTH DNA binding domain HTH_24 PF13412.6 CAV27233.1 - 0.074 12.6 0.0 0.2 11.2 0.0 1.7 2 0 0 2 2 2 0 Winged helix-turn-helix DNA-binding TetR_C_37 PF18665.1 CAV27233.1 - 0.095 13.3 0.0 0.17 12.5 0.0 1.3 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain HTH_11 PF08279.12 CAV27233.1 - 0.12 12.4 0.0 0.22 11.5 0.0 1.6 1 0 0 1 1 1 0 HTH domain HTH_Crp_2 PF13545.6 CAV27233.1 - 0.13 12.2 0.0 0.35 10.9 0.0 1.8 2 0 0 2 2 2 0 Crp-like helix-turn-helix domain Sigma70_r4 PF04545.16 CAV27233.1 - 0.22 11.1 0.0 0.73 9.4 0.0 1.8 2 0 0 2 2 2 0 Sigma-70, region 4 Ribonuc_L-PSP PF01042.21 CAV27235.1 - 4.4e-43 146.2 0.0 4.9e-43 146.0 0.0 1.0 1 0 0 1 1 1 1 Endoribonuclease L-PSP YjgF_endoribonc PF14588.6 CAV27235.1 - 0.00037 20.7 0.1 0.0019 18.3 0.1 1.9 1 1 0 1 1 1 1 YjgF/chorismate_mutase-like, putative endoribonuclease Rab3-GTPase_cat PF13890.6 CAV27235.1 - 0.063 12.9 0.0 0.078 12.6 0.0 1.2 1 0 0 1 1 1 0 Rab3 GTPase-activating protein catalytic subunit SDF PF00375.18 CAV27236.1 - 3.5e-92 309.4 46.6 4.3e-92 309.1 46.6 1.1 1 0 0 1 1 1 1 Sodium:dicarboxylate symporter family Pyr_redox_2 PF07992.14 CAV27238.1 - 1.1e-51 175.9 0.9 1.4e-51 175.4 0.9 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.22 CAV27238.1 - 2e-17 63.4 0.1 1.9e-16 60.3 0.0 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.27 CAV27238.1 - 1.5e-16 60.7 3.1 4.5e-13 49.6 0.2 3.1 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 CAV27238.1 - 1.8e-12 47.1 0.2 2e-06 27.3 0.0 2.9 1 1 1 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 CAV27238.1 - 6.8e-12 44.8 0.7 0.0011 17.8 0.0 4.0 3 1 1 4 4 4 3 HI0933-like protein DAO PF01266.24 CAV27238.1 - 1.3e-11 44.7 0.4 0.17 11.5 0.1 4.1 3 1 1 4 4 4 4 FAD dependent oxidoreductase K_oxygenase PF13434.6 CAV27238.1 - 3.8e-06 26.3 0.0 1.2e-05 24.6 0.0 1.7 2 1 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_8 PF13450.6 CAV27238.1 - 1.2e-05 25.4 0.2 0.012 15.8 0.0 2.6 2 0 0 2 2 2 2 NAD(P)-binding Rossmann-like domain AlaDh_PNT_C PF01262.21 CAV27238.1 - 4.9e-05 22.7 0.6 0.0011 18.4 0.2 2.4 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain Amino_oxidase PF01593.24 CAV27238.1 - 7.8e-05 22.1 0.0 0.19 11.0 0.0 2.2 2 0 0 2 2 2 2 Flavin containing amine oxidoreductase NAD_binding_9 PF13454.6 CAV27238.1 - 0.001 19.1 2.4 1.8 8.5 0.0 3.5 3 1 1 4 4 4 2 FAD-NAD(P)-binding 2-Hacid_dh_C PF02826.19 CAV27238.1 - 0.0068 15.8 0.0 0.046 13.1 0.0 2.1 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain TrkA_N PF02254.18 CAV27238.1 - 0.022 15.0 0.2 2.6 8.3 0.1 2.7 2 0 0 2 2 2 0 TrkA-N domain FAD_binding_2 PF00890.24 CAV27238.1 - 0.043 12.9 0.2 0.81 8.7 0.0 2.9 2 2 2 4 4 4 0 FAD binding domain Lycopene_cycl PF05834.12 CAV27238.1 - 0.044 12.8 1.6 0.69 8.9 0.0 2.9 3 1 1 4 4 4 0 Lycopene cyclase protein Rib_5-P_isom_A PF06026.14 CAV27238.1 - 0.057 13.0 0.0 0.11 12.1 0.0 1.4 1 0 0 1 1 1 0 Ribose 5-phosphate isomerase A (phosphoriboisomerase A) NAD_binding_7 PF13241.6 CAV27238.1 - 0.13 12.8 1.6 0.96 9.9 0.1 2.7 2 1 0 2 2 2 0 Putative NAD(P)-binding DUF3087 PF11286.8 CAV27239.1 - 3.3e-46 156.8 1.7 3.7e-46 156.6 1.7 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3087) PRP38 PF03371.15 CAV27239.1 - 0.00026 20.9 0.1 0.00036 20.4 0.1 1.2 1 0 0 1 1 1 1 PRP38 family Methyltrn_RNA_2 PF04013.12 CAV27241.1 - 1.7e-64 217.2 0.2 1.9e-64 217.1 0.2 1.0 1 0 0 1 1 1 1 Putative SAM-dependent RNA methyltransferase DNA_gyraseB PF00204.25 CAV27241.1 - 0.02 14.3 0.2 0.046 13.2 0.1 1.6 1 1 1 2 2 2 0 DNA gyrase B Biotin_lipoyl_2 PF13533.6 CAV27243.1 - 2.9e-07 30.2 1.9 0.0001 22.1 0.2 3.4 3 0 0 3 3 3 2 Biotin-lipoyl like HlyD_D23 PF16576.5 CAV27243.1 - 3.6e-07 29.6 1.4 3.3e-06 26.5 1.4 2.1 1 1 0 1 1 1 1 Barrel-sandwich domain of CusB or HlyD membrane-fusion HlyD_3 PF13437.6 CAV27243.1 - 4.3e-07 30.6 1.2 2.6e-06 28.1 0.1 2.7 3 0 0 3 3 3 1 HlyD family secretion protein Biotin_lipoyl PF00364.22 CAV27243.1 - 0.00012 21.9 0.8 0.022 14.6 0.1 2.8 2 0 0 2 2 2 2 Biotin-requiring enzyme Glyco_tranf_2_3 PF13641.6 CAV27245.1 - 3.2e-18 66.5 0.0 4.5e-18 66.0 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glycos_transf_2 PF00535.26 CAV27245.1 - 2.2e-17 63.4 0.0 3.3e-17 62.8 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 2 Chitin_synth_2 PF03142.15 CAV27245.1 - 1.4e-14 53.7 4.5 2.2e-06 26.6 0.0 3.1 2 1 1 3 3 3 3 Chitin synthase Glyco_trans_2_3 PF13632.6 CAV27245.1 - 7.4e-14 52.1 9.4 7.4e-14 52.1 9.4 2.9 2 1 0 2 2 2 1 Glycosyl transferase family group 2 Glyco_transf_21 PF13506.6 CAV27245.1 - 5.1e-11 42.4 0.2 8.4e-11 41.6 0.2 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 21 Glyco_tranf_2_2 PF10111.9 CAV27245.1 - 0.00036 20.1 0.0 0.00083 18.9 0.0 1.6 1 1 0 1 1 1 1 Glycosyltransferase like family 2 SDF PF00375.18 CAV27245.1 - 0.25 10.3 4.5 0.39 9.7 4.5 1.3 1 0 0 1 1 1 0 Sodium:dicarboxylate symporter family TackOD1 PF18551.1 CAV27246.1 - 2e-60 203.6 8.1 2.8e-60 203.2 8.1 1.2 1 0 0 1 1 1 1 Thaumarchaeal output domain 1 GGDEF PF00990.21 CAV27246.1 - 0.0011 18.7 0.1 0.0018 18.0 0.1 1.3 1 0 0 1 1 1 1 Diguanylate cyclase, GGDEF domain DZR PF12773.7 CAV27246.1 - 0.017 15.1 18.1 5.5 7.1 4.9 2.9 1 1 1 2 2 2 0 Double zinc ribbon Peptidase_C98 PF15499.6 CAV27246.1 - 0.46 9.9 4.2 0.78 9.2 4.2 1.4 1 0 0 1 1 1 0 Ubiquitin-specific peptidase-like, SUMO isopeptidase Zn-ribbon_8 PF09723.10 CAV27246.1 - 1 9.5 17.8 0.45 10.7 0.8 4.1 3 1 0 3 3 3 0 Zinc ribbon domain zinc-ribbons_6 PF07191.12 CAV27246.1 - 1.3 9.1 18.5 0.28 11.2 4.6 3.0 1 1 2 3 3 3 0 zinc-ribbons HypA PF01155.19 CAV27246.1 - 2.1 8.4 18.4 7.2 6.7 1.0 3.3 1 1 2 3 3 3 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA OrfB_Zn_ribbon PF07282.11 CAV27246.1 - 2.8 7.9 16.6 0.11 12.4 2.0 2.9 2 1 1 3 3 3 0 Putative transposase DNA-binding domain ArsP_1 PF03773.13 CAV27248.1 - 1e-59 202.1 15.2 1.2e-59 201.9 15.2 1.1 1 0 0 1 1 1 1 Predicted permease HTH_20 PF12840.7 CAV27252.1 - 2.3e-11 43.6 0.0 3e-11 43.2 0.0 1.1 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_5 PF01022.20 CAV27252.1 - 1.8e-05 24.5 1.3 2.2e-05 24.2 0.0 1.9 2 0 0 2 2 2 1 Bacterial regulatory protein, arsR family MarR_2 PF12802.7 CAV27252.1 - 0.00057 19.7 0.0 0.00086 19.1 0.0 1.2 1 0 0 1 1 1 1 MarR family TrmB PF01978.19 CAV27252.1 - 0.00067 19.5 0.0 0.001 18.9 0.0 1.3 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB B-block_TFIIIC PF04182.12 CAV27252.1 - 0.0018 18.4 0.0 0.0031 17.6 0.0 1.3 1 0 0 1 1 1 1 B-block binding subunit of TFIIIC HTH_24 PF13412.6 CAV27252.1 - 0.0033 16.9 0.0 0.0055 16.2 0.0 1.5 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding RP-C PF03428.13 CAV27252.1 - 0.0059 16.3 0.0 0.0086 15.7 0.0 1.2 1 0 0 1 1 1 1 Replication protein C N-terminal domain RNA_pol_Rpc34 PF05158.12 CAV27252.1 - 0.02 14.3 0.0 0.024 14.1 0.0 1.1 1 0 0 1 1 1 0 RNA polymerase Rpc34 subunit HTH_IclR PF09339.10 CAV27252.1 - 0.032 14.1 0.0 0.05 13.4 0.0 1.3 1 0 0 1 1 1 0 IclR helix-turn-helix domain PCI PF01399.27 CAV27252.1 - 0.034 14.7 0.0 0.047 14.2 0.0 1.2 1 0 0 1 1 1 0 PCI domain PRP4 PF08799.11 CAV27252.1 - 0.12 12.0 0.0 0.21 11.2 0.0 1.4 1 0 0 1 1 1 0 pre-mRNA processing factor 4 (PRP4) like Sigma70_r2 PF04542.14 CAV27254.1 - 5.6e-14 51.7 0.2 5.6e-14 51.7 0.2 1.6 2 0 0 2 2 2 1 Sigma-70 region 2 Sigma70_r4_2 PF08281.12 CAV27254.1 - 4.5e-11 42.3 0.0 1.8e-10 40.3 0.0 2.0 3 0 0 3 3 3 1 Sigma-70, region 4 Sigma70_ECF PF07638.11 CAV27254.1 - 1.6e-05 24.9 0.3 2.6e-05 24.2 0.3 1.3 1 1 0 1 1 1 1 ECF sigma factor Sigma70_r4 PF04545.16 CAV27254.1 - 1.9e-05 24.1 0.0 2.9e-05 23.5 0.0 1.3 1 0 0 1 1 1 1 Sigma-70, region 4 HTH_23 PF13384.6 CAV27254.1 - 0.00013 21.7 0.0 0.00025 20.7 0.0 1.4 1 0 0 1 1 1 1 Homeodomain-like domain GerE PF00196.19 CAV27254.1 - 0.0002 20.8 0.1 0.00036 20.0 0.1 1.4 1 0 0 1 1 1 1 Bacterial regulatory proteins, luxR family HTH_24 PF13412.6 CAV27254.1 - 0.00099 18.6 0.1 0.0016 17.9 0.1 1.3 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding HTH_28 PF13518.6 CAV27254.1 - 0.0013 18.8 0.0 0.0028 17.7 0.0 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain Phage_antitermQ PF06530.12 CAV27254.1 - 0.016 15.1 0.0 0.034 14.1 0.0 1.5 1 0 0 1 1 1 0 Phage antitermination protein Q DUF2089 PF09862.9 CAV27254.1 - 0.023 14.7 0.0 0.044 13.8 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2089) Herpes_MCP PF03122.14 CAV27254.1 - 0.039 11.4 0.2 0.044 11.3 0.2 1.0 1 0 0 1 1 1 0 Herpes virus major capsid protein HTH_AsnC-type PF13404.6 CAV27254.1 - 0.083 12.7 0.0 0.16 11.8 0.0 1.4 1 0 0 1 1 1 0 AsnC-type helix-turn-helix domain DUF1539 PF07560.11 CAV27254.1 - 0.27 11.3 2.7 1.1 9.4 0.1 2.1 2 0 0 2 2 2 0 Domain of Unknown Function (DUF1539) YitT_membrane PF02588.15 CAV27255.1 - 2.1e-32 112.1 20.9 2.6e-32 111.9 20.9 1.0 1 0 0 1 1 1 1 Uncharacterised 5xTM membrane BCR, YitT family COG1284 DUF3188 PF11384.8 CAV27255.1 - 0.23 11.2 8.7 1.9 8.3 0.1 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF3188) MFS_1 PF07690.16 CAV27259.1 - 1.4e-45 155.8 66.8 3.9e-37 128.0 41.0 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_4 PF06779.14 CAV27259.1 - 3.3e-09 36.5 25.0 5.2e-08 32.6 24.7 2.0 1 1 0 1 1 1 1 Uncharacterised MFS-type transporter YbfB MFS_1_like PF12832.7 CAV27259.1 - 5.6e-09 35.3 28.4 3.3e-08 32.8 17.1 2.2 1 1 1 2 2 2 2 MFS_1 like family MFS_2 PF13347.6 CAV27259.1 - 5.7e-08 31.7 27.7 9.3e-07 27.7 10.5 2.5 1 1 1 2 2 2 2 MFS/sugar transport protein PalH PF08733.10 CAV27259.1 - 0.13 11.2 2.7 0.19 10.7 2.7 1.2 1 0 0 1 1 1 0 PalH/RIM21 TauE PF01925.19 CAV27260.1 - 4e-23 82.3 32.1 5.2e-23 81.9 32.1 1.0 1 0 0 1 1 1 1 Sulfite exporter TauE/SafE MCPsignal PF00015.21 CAV27261.1 - 4.4e-41 140.6 18.3 4.4e-41 140.6 18.3 3.1 2 1 0 3 3 3 2 Methyl-accepting chemotaxis protein (MCP) signalling domain dCache_1 PF02743.18 CAV27261.1 - 1.4e-19 70.9 3.5 1.4e-19 70.9 3.5 3.6 2 1 1 3 3 3 1 Cache domain HAMP PF00672.25 CAV27261.1 - 7.3e-07 29.5 0.1 6.9e-05 23.2 0.0 3.2 3 0 0 3 3 2 1 HAMP domain SseC PF04888.12 CAV27261.1 - 0.0031 17.2 8.5 0.0031 17.2 8.5 3.0 3 1 1 4 4 4 1 Secretion system effector C (SseC) like family Zw10 PF06248.13 CAV27261.1 - 0.0071 15.0 16.0 0.023 13.3 4.8 2.4 2 0 0 2 2 2 2 Centromere/kinetochore Zw10 FPP PF05911.11 CAV27261.1 - 0.053 11.7 21.8 0.082 11.1 21.8 1.2 1 0 0 1 1 1 0 Filament-like plant protein, long coiled-coil DUF948 PF06103.11 CAV27261.1 - 0.061 13.6 35.0 0.38 11.1 2.6 6.0 3 2 1 5 5 5 0 Bacterial protein of unknown function (DUF948) BLOC1_2 PF10046.9 CAV27261.1 - 0.16 12.3 27.6 2.1 8.7 0.5 5.4 3 2 1 4 4 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF724 PF05266.14 CAV27261.1 - 0.59 9.9 15.4 0.8 9.5 2.2 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF724) DUF1664 PF07889.12 CAV27261.1 - 0.62 10.1 23.9 1.3 9.1 5.5 4.1 2 2 2 4 4 4 0 Protein of unknown function (DUF1664) DUF4559 PF15112.6 CAV27261.1 - 1.1 8.8 18.7 0.49 10.0 6.1 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4559) DASH_Dam1 PF08653.10 CAV27261.1 - 2.1 8.2 11.1 1.6 8.6 0.1 5.0 5 0 0 5 5 5 0 DASH complex subunit Dam1 Goodbye PF17109.5 CAV27261.1 - 3.2 8.2 10.3 64 4.0 2.8 4.8 2 2 2 5 5 5 0 fungal STAND N-terminal Goodbye domain CdvA PF18822.1 CAV27261.1 - 3.9 7.3 17.5 8 6.3 1.1 4.9 4 1 0 5 5 5 0 CdvA-like coiled-coil domain COG2 PF06148.11 CAV27261.1 - 4 7.5 20.3 0.54 10.3 1.4 4.7 2 2 1 4 4 4 0 COG (conserved oligomeric Golgi) complex component, COG2 DHR10 PF18595.1 CAV27261.1 - 8 6.5 24.5 2.9 8.0 3.8 3.9 2 2 1 3 3 3 0 Designed helical repeat protein 10 domain PAP2 PF01569.21 CAV27263.1 - 8.4e-18 64.5 0.2 8.4e-18 64.5 0.2 1.6 2 0 0 2 2 2 1 PAP2 superfamily PAP2_3 PF14378.6 CAV27263.1 - 3.1e-05 23.7 2.4 4.3e-05 23.3 2.4 1.2 1 0 0 1 1 1 1 PAP2 superfamily CM2 PF03021.14 CAV27263.1 - 0.16 11.8 0.2 0.31 10.8 0.2 1.5 1 0 0 1 1 1 0 Influenza C virus M2 protein DHBP_synthase PF00926.19 CAV27265.1 - 1.5e-77 259.5 0.8 1.7e-77 259.3 0.8 1.0 1 0 0 1 1 1 1 3,4-dihydroxy-2-butanone 4-phosphate synthase SBP_bac_5 PF00496.22 CAV27267.1 - 7.5e-70 235.8 0.0 2.1e-69 234.3 0.0 1.6 2 0 0 2 2 2 1 Bacterial extracellular solute-binding proteins, family 5 Middle BPD_transp_1 PF00528.22 CAV27268.1 - 9e-32 110.3 9.2 9e-32 110.3 9.2 2.0 3 0 0 3 3 3 1 Binding-protein-dependent transport system inner membrane component Peptidase_M48_N PF16491.5 CAV27268.1 - 0.2 11.5 2.1 0.21 11.5 0.3 1.9 2 0 0 2 2 2 0 CAAX prenyl protease N-terminal, five membrane helices BNIP3 PF06553.12 CAV27268.1 - 0.23 11.1 0.0 0.38 10.4 0.0 1.3 1 0 0 1 1 1 0 BNIP3 BPD_transp_1 PF00528.22 CAV27270.1 - 4.6e-17 62.3 8.9 4.6e-17 62.3 8.9 1.8 2 1 0 2 2 2 1 Binding-protein-dependent transport system inner membrane component VPDSG-CTERM PF18205.1 CAV27270.1 - 0.021 14.6 0.1 0.021 14.6 0.1 3.9 4 0 0 4 4 4 0 VPDSG-CTERM motif OSTbeta PF15048.6 CAV27270.1 - 0.33 11.1 0.0 0.33 11.1 0.0 2.1 3 0 0 3 3 3 0 Organic solute transporter subunit beta protein ABC_tran PF00005.27 CAV27274.1 - 1.9e-39 135.3 0.0 4.2e-19 69.4 0.0 2.3 2 0 0 2 2 2 2 ABC transporter AAA_22 PF13401.6 CAV27274.1 - 3.4e-09 37.1 0.3 4.5e-05 23.8 0.0 2.6 2 1 0 2 2 2 2 AAA domain AAA_21 PF13304.6 CAV27274.1 - 7.9e-07 29.2 3.9 0.0066 16.3 0.3 3.4 2 2 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_16 PF13191.6 CAV27274.1 - 6.6e-06 26.6 0.1 0.0011 19.3 0.0 2.4 2 0 0 2 2 2 1 AAA ATPase domain RsgA_GTPase PF03193.16 CAV27274.1 - 6e-05 23.0 0.1 0.026 14.4 0.0 2.3 2 0 0 2 2 2 1 RsgA GTPase oligo_HPY PF08352.12 CAV27274.1 - 0.0001 22.7 0.0 0.00025 21.5 0.0 1.7 1 0 0 1 1 1 1 Oligopeptide/dipeptide transporter, C-terminal region AAA_23 PF13476.6 CAV27274.1 - 0.00013 22.6 0.0 0.53 10.8 0.0 2.2 2 0 0 2 2 2 2 AAA domain DUF87 PF01935.17 CAV27274.1 - 0.00019 21.6 0.1 0.012 15.8 0.0 2.3 2 0 0 2 2 2 1 Helicase HerA, central domain AAA_29 PF13555.6 CAV27274.1 - 0.00061 19.5 1.1 0.17 11.7 0.3 2.4 2 0 0 2 2 2 1 P-loop containing region of AAA domain RNA_helicase PF00910.22 CAV27274.1 - 0.0018 18.6 0.0 0.55 10.7 0.0 2.4 2 0 0 2 2 2 1 RNA helicase Sigma54_activat PF00158.26 CAV27274.1 - 0.0068 16.1 0.0 0.46 10.2 0.0 2.3 2 0 0 2 2 2 1 Sigma-54 interaction domain SMC_N PF02463.19 CAV27274.1 - 0.0071 15.8 0.1 6.2 6.2 0.0 3.5 4 0 0 4 4 4 1 RecF/RecN/SMC N terminal domain Mg_chelatase PF01078.21 CAV27274.1 - 0.011 15.2 0.1 0.94 8.8 0.0 2.5 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI NACHT PF05729.12 CAV27274.1 - 0.014 15.3 0.0 6.9 6.6 0.0 2.6 2 0 0 2 2 2 0 NACHT domain AAA_7 PF12775.7 CAV27274.1 - 0.032 13.7 0.0 1.5 8.3 0.0 2.2 2 0 0 2 2 2 0 P-loop containing dynein motor region NB-ARC PF00931.22 CAV27274.1 - 0.038 13.2 0.0 1.1 8.3 0.0 2.1 2 0 0 2 2 2 0 NB-ARC domain AAA PF00004.29 CAV27274.1 - 0.062 13.7 0.0 19 5.7 0.0 2.8 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) PhoH PF02562.16 CAV27274.1 - 0.076 12.5 0.0 6.8 6.1 0.0 2.4 2 0 0 2 2 2 0 PhoH-like protein AAA_5 PF07728.14 CAV27274.1 - 0.078 13.0 0.4 17 5.4 0.0 3.0 2 1 1 3 3 3 0 AAA domain (dynein-related subfamily) ATP-synt_ab PF00006.25 CAV27274.1 - 0.091 12.4 0.0 0.38 10.4 0.0 1.8 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain IstB_IS21 PF01695.17 CAV27274.1 - 0.14 11.9 0.0 11 5.6 0.0 2.5 2 0 0 2 2 2 0 IstB-like ATP binding protein PRK PF00485.18 CAV27274.1 - 0.21 11.3 0.0 0.77 9.5 0.0 1.9 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family AAA_24 PF13479.6 CAV27274.1 - 0.22 11.2 0.1 2.7 7.7 0.0 2.1 2 0 0 2 2 2 0 AAA domain ER PF01133.17 CAV27276.1 - 0.0072 16.3 3.3 1.7 8.7 0.2 2.8 3 0 0 3 3 3 2 Enhancer of rudimentary LysR_substrate PF03466.20 CAV27279.1 - 5.8e-38 130.4 0.0 7.9e-38 129.9 0.0 1.2 1 0 0 1 1 1 1 LysR substrate binding domain HTH_1 PF00126.27 CAV27279.1 - 3.5e-17 62.1 1.9 4e-17 61.9 0.9 1.7 2 0 0 2 2 2 1 Bacterial regulatory helix-turn-helix protein, lysR family NAD_binding_7 PF13241.6 CAV27279.1 - 0.033 14.6 0.1 0.071 13.6 0.1 1.6 1 1 0 1 1 1 0 Putative NAD(P)-binding NAD_binding_10 PF13460.6 CAV27280.1 - 2.7e-29 102.4 0.1 3.3e-29 102.1 0.1 1.0 1 0 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 CAV27280.1 - 1e-09 38.3 0.2 1.4e-09 37.8 0.2 1.3 1 0 0 1 1 1 1 NmrA-like family Epimerase PF01370.21 CAV27280.1 - 1.6e-07 31.0 0.2 2.6e-07 30.4 0.2 1.5 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family DapB_N PF01113.20 CAV27280.1 - 0.0014 18.7 0.2 0.0023 18.0 0.2 1.4 1 0 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus 3HCDH_N PF02737.18 CAV27280.1 - 0.0019 18.1 0.4 0.0026 17.7 0.4 1.2 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain RmlD_sub_bind PF04321.17 CAV27280.1 - 0.0021 17.2 0.1 0.0035 16.5 0.1 1.3 1 0 0 1 1 1 1 RmlD substrate binding domain UDPG_MGDP_dh_N PF03721.14 CAV27280.1 - 0.012 15.2 0.1 0.02 14.5 0.1 1.5 1 1 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain GDP_Man_Dehyd PF16363.5 CAV27280.1 - 0.012 15.0 0.0 0.018 14.4 0.0 1.2 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase NAD_binding_2 PF03446.15 CAV27280.1 - 0.018 15.2 0.1 0.026 14.7 0.1 1.2 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase DFP PF04127.15 CAV27280.1 - 0.019 14.8 0.3 0.031 14.1 0.3 1.3 1 0 0 1 1 1 0 DNA / pantothenate metabolism flavoprotein TrkA_N PF02254.18 CAV27280.1 - 0.024 14.9 0.3 0.039 14.2 0.3 1.4 1 0 0 1 1 1 0 TrkA-N domain Rimk_N PF18030.1 CAV27280.1 - 0.027 14.9 0.0 0.06 13.8 0.0 1.6 1 0 0 1 1 1 0 RimK PreATP-grasp domain Ldh_1_N PF00056.23 CAV27280.1 - 0.032 14.3 0.3 0.048 13.7 0.3 1.4 1 0 0 1 1 1 0 lactate/malate dehydrogenase, NAD binding domain Sacchrp_dh_NADP PF03435.18 CAV27280.1 - 0.032 14.5 0.4 0.049 13.9 0.4 1.3 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain adh_short PF00106.25 CAV27280.1 - 0.054 12.9 0.3 0.071 12.6 0.3 1.3 1 0 0 1 1 1 0 short chain dehydrogenase 3Beta_HSD PF01073.19 CAV27280.1 - 0.11 11.4 0.1 0.15 11.1 0.1 1.2 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family CoA_binding_2 PF13380.6 CAV27280.1 - 0.13 12.8 0.1 0.25 11.9 0.1 1.5 1 1 0 1 1 1 0 CoA binding domain MoCF_biosynth PF00994.24 CAV27280.1 - 0.14 11.8 0.3 0.29 10.8 0.3 1.5 1 1 0 1 1 1 0 Probable molybdopterin binding domain Acyl-CoA_dh_C PF12806.7 CAV27280.1 - 0.15 12.2 0.0 0.24 11.6 0.0 1.3 1 0 0 1 1 1 0 Acetyl-CoA dehydrogenase C-terminal like Cupin_7 PF12973.7 CAV27282.1 - 1.7e-72 239.3 2.4 6.9e-40 134.9 0.0 2.0 2 0 0 2 2 2 2 ChrR Cupin-like domain Cupin_2 PF07883.11 CAV27282.1 - 1.8e-08 33.9 2.2 0.0033 17.1 0.3 2.7 2 1 0 2 2 2 2 Cupin domain DUF4437 PF14499.6 CAV27282.1 - 0.0002 20.6 0.0 0.007 15.5 0.0 2.1 1 1 1 2 2 2 2 Domain of unknown function (DUF4437) DUF4863 PF16155.5 CAV27282.1 - 0.0093 15.8 0.5 0.047 13.6 0.0 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF4863) adh_short_C2 PF13561.6 CAV27284.1 - 5.2e-50 170.2 0.3 5.9e-50 170.0 0.3 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CAV27284.1 - 3.5e-44 150.6 0.8 4.2e-44 150.4 0.8 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CAV27284.1 - 1.4e-07 31.6 0.6 2.3e-07 30.9 0.6 1.4 1 1 0 1 1 1 1 KR domain Epimerase PF01370.21 CAV27284.1 - 0.0031 17.0 0.3 0.0046 16.4 0.3 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family TrkA_N PF02254.18 CAV27284.1 - 0.024 14.9 0.0 0.058 13.7 0.0 1.7 2 1 0 2 2 2 0 TrkA-N domain Nitro_FeMo-Co PF02579.17 CAV27284.1 - 0.1 12.9 0.2 0.51 10.7 0.0 2.2 2 0 0 2 2 2 0 Dinitrogenase iron-molybdenum cofactor 3HCDH_N PF02737.18 CAV27284.1 - 0.13 12.2 0.3 0.27 11.1 0.1 1.7 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain HxlR PF01638.17 CAV27286.1 - 1.1e-14 54.1 0.0 1.4e-14 53.7 0.0 1.2 1 0 0 1 1 1 1 HxlR-like helix-turn-helix LysR_substrate PF03466.20 CAV27288.1 - 7e-39 133.4 0.0 1.1e-38 132.8 0.0 1.2 1 0 0 1 1 1 1 LysR substrate binding domain HTH_1 PF00126.27 CAV27288.1 - 4.2e-21 74.7 0.5 7.3e-21 73.9 0.5 1.4 1 0 0 1 1 1 1 Bacterial regulatory helix-turn-helix protein, lysR family MarR PF01047.22 CAV27288.1 - 0.14 12.1 0.0 4.3 7.3 0.0 2.4 2 0 0 2 2 2 0 MarR family adh_short PF00106.25 CAV27290.1 - 5.4e-52 176.1 0.4 6.6e-52 175.8 0.4 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CAV27290.1 - 5.9e-39 134.0 0.6 7.3e-39 133.7 0.6 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CAV27290.1 - 9.9e-13 48.4 0.4 1.8e-12 47.6 0.4 1.4 1 1 0 1 1 1 1 KR domain NAD_binding_10 PF13460.6 CAV27290.1 - 3e-10 40.3 0.3 3.6e-10 40.0 0.3 1.1 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 CAV27290.1 - 4.1e-07 29.7 0.2 2.3e-06 27.3 0.1 2.1 2 1 0 2 2 2 1 NAD dependent epimerase/dehydratase family NmrA PF05368.13 CAV27290.1 - 0.0008 19.0 0.1 0.032 13.8 0.0 2.2 1 1 1 2 2 2 1 NmrA-like family ApbA PF02558.16 CAV27290.1 - 0.016 14.9 0.1 0.036 13.7 0.1 1.6 1 1 0 1 1 1 0 Ketopantoate reductase PanE/ApbA OmpW PF03922.14 CAV27291.1 - 4.8e-72 241.9 0.2 5.5e-72 241.7 0.2 1.0 1 0 0 1 1 1 1 OmpW family OMP_b-brl PF13505.6 CAV27291.1 - 1e-16 61.6 8.1 1.3e-16 61.3 8.1 1.1 1 0 0 1 1 1 1 Outer membrane protein beta-barrel domain OprF PF05736.11 CAV27291.1 - 3.1e-06 27.0 0.8 6.2e-06 26.1 0.8 1.8 1 1 0 1 1 1 1 OprF membrane domain Opacity PF02462.15 CAV27291.1 - 0.00015 21.8 0.2 0.00041 20.4 0.1 1.8 1 1 1 2 2 2 1 Opacity family porin protein OMP_b-brl_2 PF13568.6 CAV27291.1 - 0.0012 18.9 1.1 0.0065 16.5 0.4 2.3 2 1 1 3 3 3 2 Outer membrane protein beta-barrel domain DUF4148 PF13663.6 CAV27291.1 - 0.14 12.3 0.1 0.25 11.6 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4148) TUG-UBL1 PF11470.8 CAV27291.1 - 0.17 12.1 0.0 0.38 11.0 0.0 1.5 1 0 0 1 1 1 0 TUG ubiquitin-like domain NTP_transferase PF00483.23 CAV27293.1 - 2e-67 227.4 0.0 2.4e-67 227.1 0.0 1.1 1 0 0 1 1 1 1 Nucleotidyl transferase NTP_transf_3 PF12804.7 CAV27293.1 - 3.9e-09 37.1 0.0 5.6e-09 36.6 0.0 1.3 1 0 0 1 1 1 1 MobA-like NTP transferase domain Fucokinase PF07959.12 CAV27293.1 - 1.5e-06 27.5 0.8 9.9e-05 21.4 0.5 2.2 2 0 0 2 2 2 2 L-fucokinase DUF4354 PF14263.6 CAV27293.1 - 0.0042 16.9 0.0 0.011 15.6 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4354) Hexapep PF00132.24 CAV27293.1 - 0.0044 16.7 6.6 0.018 14.7 1.5 2.9 2 1 0 2 2 2 1 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 CAV27293.1 - 1.8 8.4 4.6 7.6 6.4 0.2 3.1 2 1 1 3 3 3 0 Hexapeptide repeat of succinyl-transferase Ribosomal_S30AE PF02482.19 CAV27295.1 - 1.2e-13 51.6 0.2 1.4e-13 51.4 0.2 1.1 1 0 0 1 1 1 1 Sigma 54 modulation protein / S30EA ribosomal protein DUF5359 PF17313.2 CAV27295.1 - 0.08 12.9 0.0 0.14 12.2 0.0 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5359) DUF3012 PF11216.8 CAV27297.1 - 1.5e-22 79.3 2.6 1.9e-22 79.0 2.6 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3012) Hydrolase_3 PF08282.12 CAV27299.1 - 4.6e-14 52.8 0.0 3.3e-07 30.3 0.0 2.1 1 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase S6PP PF05116.13 CAV27299.1 - 0.0018 17.8 0.5 0.0082 15.7 0.0 2.1 2 1 0 2 2 2 1 Sucrose-6F-phosphate phosphohydrolase Hydrolase PF00702.26 CAV27299.1 - 0.0034 17.7 2.1 0.86 9.8 2.1 2.8 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Trehalose_PPase PF02358.16 CAV27299.1 - 0.0041 16.3 0.0 0.043 12.9 0.0 2.0 2 0 0 2 2 2 1 Trehalose-phosphatase GFRP PF06399.13 CAV27299.1 - 0.013 15.4 0.0 3.6 7.5 0.0 2.5 2 0 0 2 2 2 0 GTP cyclohydrolase I feedback regulatory protein (GFRP) Hydrolase_6 PF13344.6 CAV27299.1 - 0.015 15.4 0.2 0.22 11.6 0.0 2.6 2 1 1 3 3 3 0 Haloacid dehalogenase-like hydrolase HAD PF12710.7 CAV27299.1 - 0.018 15.5 1.0 5.1 7.5 0.0 2.9 2 1 1 3 3 3 0 haloacid dehalogenase-like hydrolase BPD_transp_1 PF00528.22 CAV27301.1 - 9.5e-12 45.0 17.6 1.7e-11 44.2 17.6 1.4 1 0 0 1 1 1 1 Binding-protein-dependent transport system inner membrane component BPD_transp_1 PF00528.22 CAV27303.1 - 6.1e-17 61.9 17.7 6.1e-17 61.9 17.7 2.0 1 1 0 2 2 2 1 Binding-protein-dependent transport system inner membrane component DUF3481 PF11980.8 CAV27303.1 - 0.0059 16.3 1.3 1.6 8.5 0.0 2.5 2 0 0 2 2 2 2 C-terminal domain of neuropilin glycoprotein ABC_tran PF00005.27 CAV27305.1 - 4.1e-36 124.5 0.0 5.9e-36 124.0 0.0 1.2 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 CAV27305.1 - 9.9e-09 35.4 0.0 0.00031 20.7 0.0 2.2 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 CAV27305.1 - 1.5e-05 25.6 0.3 3.1e-05 24.6 0.3 1.5 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 CAV27305.1 - 1.8e-05 25.0 0.1 8.6e-05 22.8 0.1 2.1 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 CAV27305.1 - 4.2e-05 24.0 0.1 7.2e-05 23.2 0.1 1.6 1 1 0 1 1 1 1 AAA ATPase domain AAA_29 PF13555.6 CAV27305.1 - 4.5e-05 23.1 0.0 8.3e-05 22.3 0.0 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 CAV27305.1 - 0.00089 19.2 0.1 0.0066 16.4 0.0 2.1 2 0 0 2 2 2 1 RsgA GTPase AAA_15 PF13175.6 CAV27305.1 - 0.0011 18.7 0.1 0.0021 17.8 0.0 1.5 2 0 0 2 2 2 1 AAA ATPase domain SMC_N PF02463.19 CAV27305.1 - 0.0034 16.8 0.1 0.071 12.5 0.1 2.1 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_18 PF13238.6 CAV27305.1 - 0.0046 17.5 0.1 0.014 15.9 0.1 2.0 1 1 0 1 1 1 1 AAA domain Adeno_IVa2 PF02456.15 CAV27305.1 - 0.006 15.4 0.1 0.012 14.4 0.1 1.5 2 0 0 2 2 2 1 Adenovirus IVa2 protein NB-ARC PF00931.22 CAV27305.1 - 0.018 14.2 0.0 0.032 13.4 0.0 1.4 1 0 0 1 1 1 0 NB-ARC domain AAA_28 PF13521.6 CAV27305.1 - 0.022 15.0 0.0 0.057 13.7 0.0 1.8 2 1 1 3 3 2 0 AAA domain AAA_30 PF13604.6 CAV27305.1 - 0.024 14.4 0.0 0.039 13.7 0.0 1.3 1 0 0 1 1 1 0 AAA domain MMR_HSR1 PF01926.23 CAV27305.1 - 0.05 13.7 0.1 0.098 12.7 0.1 1.9 1 1 0 1 1 1 0 50S ribosome-binding GTPase AAA_24 PF13479.6 CAV27305.1 - 0.063 13.0 0.0 0.1 12.3 0.0 1.3 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 CAV27305.1 - 0.064 13.2 0.3 0.57 10.1 0.1 2.1 1 1 1 2 2 2 0 NACHT domain AAA_33 PF13671.6 CAV27305.1 - 0.083 13.1 0.2 0.21 11.7 0.1 1.7 2 1 0 2 2 2 0 AAA domain AAA_14 PF13173.6 CAV27305.1 - 0.088 12.8 0.0 1.1 9.3 0.0 2.1 2 0 0 2 2 2 0 AAA domain ComC PF03047.14 CAV27305.1 - 0.09 12.6 0.4 0.19 11.5 0.4 1.6 1 0 0 1 1 1 0 COMC family T2SSE PF00437.20 CAV27305.1 - 0.092 11.8 0.0 0.14 11.2 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_13 PF13166.6 CAV27305.1 - 0.11 11.1 0.0 4.1 5.9 0.0 2.0 2 0 0 2 2 2 0 AAA domain Cytidylate_kin PF02224.18 CAV27305.1 - 0.12 12.1 0.1 0.27 10.9 0.0 1.7 2 0 0 2 2 1 0 Cytidylate kinase AAA PF00004.29 CAV27305.1 - 0.12 12.8 0.0 0.28 11.6 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) ABC_ATPase PF09818.9 CAV27305.1 - 0.12 11.1 0.1 0.29 9.9 0.0 1.5 2 0 0 2 2 2 0 Predicted ATPase of the ABC class AAA_19 PF13245.6 CAV27305.1 - 0.14 12.5 0.0 0.2 12.0 0.0 1.4 1 1 0 1 1 1 0 AAA domain AAA_5 PF07728.14 CAV27305.1 - 0.15 12.1 0.0 0.65 10.0 0.0 2.0 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) Phosphonate-bd PF12974.7 CAV27307.1 - 4e-57 193.6 0.1 5.4e-57 193.2 0.1 1.1 1 0 0 1 1 1 1 ABC transporter, phosphonate, periplasmic substrate-binding protein SBP_bac_3 PF00497.20 CAV27307.1 - 1.5e-06 27.8 0.0 4.5e-06 26.3 0.0 1.7 1 1 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 NMT1 PF09084.11 CAV27307.1 - 0.00023 21.2 0.0 0.00055 19.9 0.0 1.7 1 1 1 2 2 2 1 NMT1/THI5 like NMT1_3 PF16868.5 CAV27307.1 - 0.0046 16.4 0.0 0.099 12.0 0.0 2.3 2 0 0 2 2 2 1 NMT1-like family GDPD PF03009.17 CAV27308.1 - 1.1e-24 87.6 0.1 1.4e-24 87.2 0.1 1.2 1 0 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family Sigma54_activat PF00158.26 CAV27310.1 - 1.2e-63 213.8 0.4 1.8e-63 213.2 0.4 1.3 1 0 0 1 1 1 1 Sigma-54 interaction domain Response_reg PF00072.24 CAV27310.1 - 2.1e-28 98.7 0.1 5.5e-28 97.4 0.1 1.8 1 0 0 1 1 1 1 Response regulator receiver domain Sigma54_activ_2 PF14532.6 CAV27310.1 - 2.1e-19 70.0 0.0 9.4e-19 67.9 0.0 2.1 2 1 0 2 2 1 1 Sigma-54 interaction domain HTH_8 PF02954.19 CAV27310.1 - 1.1e-10 41.1 0.7 2.2e-10 40.1 0.2 1.9 2 0 0 2 2 2 1 Bacterial regulatory protein, Fis family AAA_5 PF07728.14 CAV27310.1 - 1.4e-06 28.3 0.0 3.3e-06 27.1 0.0 1.7 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 CAV27310.1 - 2e-05 24.8 0.1 2e-05 24.8 0.1 1.7 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA PF00004.29 CAV27310.1 - 0.00012 22.5 2.2 0.0003 21.2 0.1 2.8 3 0 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) Mg_chelatase PF01078.21 CAV27310.1 - 0.0012 18.2 0.2 0.31 10.4 0.0 2.2 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI FleQ PF06490.11 CAV27310.1 - 0.019 15.3 0.0 0.05 14.0 0.0 1.8 1 1 0 1 1 1 0 Flagellar regulatory protein FleQ HTH_30 PF13556.6 CAV27310.1 - 0.097 12.5 0.0 0.29 11.0 0.0 1.8 1 0 0 1 1 1 0 PucR C-terminal helix-turn-helix domain TrmB PF01978.19 CAV27310.1 - 0.099 12.5 0.3 0.31 10.9 0.1 1.8 2 0 0 2 2 2 0 Sugar-specific transcriptional regulator TrmB AAA_7 PF12775.7 CAV27310.1 - 0.12 11.9 0.0 0.24 10.9 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region ThiG PF05690.14 CAV27310.1 - 0.14 11.4 0.2 0.38 10.0 0.2 1.6 1 1 0 1 1 1 0 Thiazole biosynthesis protein ThiG HATPase_c PF02518.26 CAV27312.1 - 4.6e-25 88.3 0.1 1.2e-24 86.9 0.1 1.8 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_5 PF14501.6 CAV27312.1 - 2.3e-06 27.4 0.0 7.2e-06 25.8 0.0 1.9 1 0 0 1 1 1 1 GHKL domain HATPase_c_3 PF13589.6 CAV27312.1 - 8.7e-06 25.6 0.0 2.3e-05 24.2 0.0 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 CAV27312.1 - 2.9e-05 24.0 0.0 2.9e-05 24.0 0.0 2.8 4 0 0 4 4 4 1 His Kinase A (phospho-acceptor) domain HAMP PF00672.25 CAV27312.1 - 0.00017 21.9 0.0 0.00058 20.2 0.0 2.0 1 0 0 1 1 1 1 HAMP domain TPR_19 PF14559.6 CAV27312.1 - 0.0039 17.7 0.6 10 6.7 0.0 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat Cytochrom_B562 PF07361.11 CAV27312.1 - 1.8 9.3 13.4 9.3 7.0 1.6 4.2 3 2 1 4 4 4 0 Cytochrome b562 GyrI-like PF06445.15 CAV27313.1 - 1.2e-37 129.6 0.0 1.9e-37 129.0 0.0 1.3 1 0 0 1 1 1 1 GyrI-like small molecule binding domain Cass2 PF14526.6 CAV27313.1 - 4.3e-22 78.9 0.0 7.6e-22 78.1 0.0 1.4 1 0 0 1 1 1 1 Integron-associated effector binding protein HTH_18 PF12833.7 CAV27313.1 - 1.3e-16 60.6 2.2 1.7e-16 60.3 0.8 1.8 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_AraC PF00165.23 CAV27313.1 - 7e-14 51.5 0.7 7.8e-06 25.9 0.1 2.3 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family GATase_4 PF13230.6 CAV27319.1 - 3.9e-20 71.9 0.1 3.3e-18 65.6 0.0 2.0 1 1 1 2 2 2 2 Glutamine amidotransferases class-II GATase_6 PF13522.6 CAV27319.1 - 1e-09 38.7 0.0 1.6e-09 38.1 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase domain MR_MLE_C PF13378.6 CAV27321.1 - 9.7e-29 100.5 0.1 1.2e-28 100.2 0.1 1.1 1 0 0 1 1 1 1 Enolase C-terminal domain-like MR_MLE_N PF02746.16 CAV27321.1 - 6.3e-09 36.1 0.0 1.8e-08 34.6 0.0 1.8 1 0 0 1 1 1 1 Mandelate racemase / muconate lactonizing enzyme, N-terminal domain Ring_hydroxyl_A PF00848.19 CAV27321.1 - 0.14 12.1 0.0 0.2 11.6 0.0 1.2 1 0 0 1 1 1 0 Ring hydroxylating alpha subunit (catalytic domain) Enolase_C PF00113.22 CAV27321.1 - 0.15 11.2 0.0 0.24 10.6 0.0 1.4 1 0 0 1 1 1 0 Enolase, C-terminal TIM barrel domain DUF1611 PF07755.11 CAV27323.1 - 3.2e-70 235.5 0.1 5e-70 234.9 0.1 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1611_C) P-loop domain DUF1611_N PF17396.2 CAV27323.1 - 1.9e-21 76.1 0.0 5.5e-21 74.6 0.0 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF1611_N) Rossmann-like domain LysR_substrate PF03466.20 CAV27325.1 - 3.8e-27 95.0 0.9 5.4e-27 94.5 0.9 1.1 1 0 0 1 1 1 1 LysR substrate binding domain HTH_1 PF00126.27 CAV27325.1 - 3.8e-17 62.0 0.1 8.3e-17 60.9 0.1 1.6 1 0 0 1 1 1 1 Bacterial regulatory helix-turn-helix protein, lysR family MarR_2 PF12802.7 CAV27325.1 - 0.0076 16.1 0.1 0.016 15.1 0.1 1.6 1 0 0 1 1 1 1 MarR family Lipase_GDSL_2 PF13472.6 CAV27327.1 - 1.6e-23 84.1 0.0 5.2e-23 82.4 0.0 1.8 2 0 0 2 2 2 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 CAV27327.1 - 2.4e-13 50.5 0.8 4e-12 46.5 0.4 2.6 2 1 0 2 2 2 1 GDSL-like Lipase/Acylhydrolase Alpha-amylase PF00128.24 CAV27328.1 - 4.9e-44 151.3 0.1 6.7e-26 91.6 0.1 2.3 2 0 0 2 2 2 2 Alpha amylase, catalytic domain DUF3459 PF11941.8 CAV27328.1 - 0.024 14.9 0.0 0.055 13.8 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3459) SpoU_methylase PF00588.19 CAV27330.1 - 2.3e-20 73.2 0.0 3e-20 72.8 0.0 1.1 1 0 0 1 1 1 1 SpoU rRNA Methylase family Cu_amine_oxidN3 PF02728.16 CAV27330.1 - 0.021 15.2 0.0 0.047 14.1 0.0 1.5 2 0 0 2 2 2 0 Copper amine oxidase, N3 domain MCPsignal PF00015.21 CAV27331.1 - 2.5e-38 131.6 29.4 2.5e-38 131.6 29.4 3.0 2 1 1 3 3 3 2 Methyl-accepting chemotaxis protein (MCP) signalling domain sCache_2 PF17200.4 CAV27331.1 - 1.4e-25 89.9 0.1 1.4e-25 89.9 0.1 3.5 3 1 0 3 3 3 1 Single Cache domain 2 dCache_2 PF08269.11 CAV27331.1 - 6.5e-22 78.1 0.1 6.5e-22 78.1 0.1 3.7 2 2 4 6 6 6 1 Cache domain HAMP PF00672.25 CAV27331.1 - 3.4e-06 27.3 2.0 3.9e-05 23.9 0.0 3.3 4 0 0 4 4 4 1 HAMP domain Clusterin PF01093.17 CAV27331.1 - 0.0018 17.4 0.9 0.0018 17.4 0.9 2.2 1 1 1 2 2 2 1 Clusterin HrpB7 PF09486.10 CAV27331.1 - 0.024 15.0 27.7 0.48 10.8 13.4 3.2 2 1 1 3 3 3 0 Bacterial type III secretion protein (HrpB7) Mur_ligase_C PF02875.21 CAV27331.1 - 0.032 14.5 0.3 0.92 9.8 0.1 3.0 2 1 1 3 3 3 0 Mur ligase family, glutamate ligase domain Virul_fac_BrkB PF03631.15 CAV27331.1 - 0.097 12.3 1.2 1.3 8.5 0.1 2.6 2 0 0 2 2 2 0 Virulence factor BrkB DUF4064 PF13273.6 CAV27331.1 - 0.17 12.2 2.9 14 6.0 0.1 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF4064) Syntaxin-6_N PF09177.11 CAV27331.1 - 2.2 8.9 18.8 0.68 10.5 1.8 4.0 3 1 1 4 4 4 0 Syntaxin 6, N-terminal DUF2408 PF10303.9 CAV27331.1 - 6.8 7.3 12.9 4.2 7.9 3.0 2.8 2 1 0 2 2 2 0 Protein of unknown function (DUF2408) LysR_substrate PF03466.20 CAV27333.1 - 2.8e-47 160.8 0.0 3.4e-47 160.5 0.0 1.1 1 0 0 1 1 1 1 LysR substrate binding domain HTH_1 PF00126.27 CAV27333.1 - 7.7e-18 64.2 2.9 1.5e-17 63.2 2.9 1.5 1 0 0 1 1 1 1 Bacterial regulatory helix-turn-helix protein, lysR family DUF3316 PF11777.8 CAV27334.1 - 8.3e-22 77.8 0.9 1e-21 77.5 0.9 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3316) PepSY_2 PF13670.6 CAV27334.1 - 0.22 11.6 3.2 0.32 11.0 0.4 2.2 2 1 0 2 2 2 0 Peptidase propeptide and YPEB domain MCPsignal PF00015.21 CAV27336.1 - 3.1e-43 147.6 21.3 3.1e-43 147.6 21.3 3.8 2 1 2 4 4 4 2 Methyl-accepting chemotaxis protein (MCP) signalling domain HAMP PF00672.25 CAV27336.1 - 7.8e-13 48.6 0.0 9.5e-11 41.9 0.0 3.4 3 0 0 3 3 3 1 HAMP domain YccJ PF13993.6 CAV27336.1 - 0.029 14.7 2.2 0.053 13.9 0.0 2.5 3 0 0 3 3 3 0 YccJ-like protein TBK1_CCD1 PF18394.1 CAV27336.1 - 0.084 12.4 10.5 0.19 11.3 1.8 2.6 2 1 0 2 2 2 0 TANK-binding kinase 1 coiled-coil domain 1 UPF0449 PF15136.6 CAV27336.1 - 0.74 10.3 5.1 0.46 11.0 0.8 2.9 2 1 0 2 2 2 0 Uncharacterised protein family UPF0449 DUF948 PF06103.11 CAV27336.1 - 0.82 10.0 28.7 0.22 11.8 2.1 5.8 3 1 1 4 4 4 0 Bacterial protein of unknown function (DUF948) Terminase_4 PF05119.12 CAV27336.1 - 2.2 8.8 9.1 2.9 8.4 0.4 3.7 2 1 1 3 3 3 0 Phage terminase, small subunit CREPT PF16566.5 CAV27336.1 - 2.5 8.3 11.3 0.99 9.6 0.7 3.3 3 0 0 3 3 3 0 Cell-cycle alteration and expression-elevated protein in tumour Methyltransf_32 PF13679.6 CAV27336.1 - 3.3 7.7 8.8 1.9 8.4 1.3 3.0 2 1 0 2 2 2 0 Methyltransferase domain TPR_MLP1_2 PF07926.12 CAV27336.1 - 6.5 6.8 20.8 0.095 12.8 6.3 3.0 3 0 0 3 3 3 0 TPR/MLP1/MLP2-like protein BMFP PF04380.13 CAV27336.1 - 7.3 7.2 11.1 1.4 9.4 1.1 4.2 4 0 0 4 4 4 0 Membrane fusogenic activity DUF3010 PF11215.8 CAV27338.1 - 8.7e-62 207.5 0.2 9.8e-62 207.3 0.2 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3010) EamA PF00892.20 CAV27340.1 - 2.7e-23 82.7 37.9 1.8e-12 47.6 16.1 2.0 2 0 0 2 2 2 2 EamA-like transporter family Aminotran_1_2 PF00155.21 CAV27342.1 - 3.3e-23 82.4 0.0 4.6e-23 82.0 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II GntR PF00392.21 CAV27342.1 - 2.7e-16 59.0 0.0 7e-16 57.6 0.0 1.8 1 0 0 1 1 1 1 Bacterial regulatory proteins, gntR family HTH_36 PF13730.6 CAV27342.1 - 8.4e-07 28.9 0.0 2e-06 27.6 0.0 1.6 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_11 PF08279.12 CAV27342.1 - 5.3e-06 26.3 0.0 1.3e-05 25.0 0.0 1.7 1 0 0 1 1 1 1 HTH domain HTH_24 PF13412.6 CAV27342.1 - 0.00021 20.8 0.0 0.00048 19.6 0.0 1.7 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding HTH_IclR PF09339.10 CAV27342.1 - 0.00059 19.6 0.0 0.0011 18.7 0.0 1.5 1 0 0 1 1 1 1 IclR helix-turn-helix domain TrmB PF01978.19 CAV27342.1 - 0.0053 16.6 0.0 0.014 15.3 0.0 1.7 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB HTH_50 PF18024.1 CAV27342.1 - 0.0074 15.9 0.0 0.03 13.9 0.0 1.9 2 0 0 2 2 2 1 Helix-turn-helix domain MarR_2 PF12802.7 CAV27342.1 - 0.0075 16.1 0.0 0.022 14.7 0.0 1.7 1 0 0 1 1 1 1 MarR family Rrf2 PF02082.20 CAV27342.1 - 0.0076 16.6 0.0 0.021 15.2 0.0 1.7 1 0 0 1 1 1 1 Transcriptional regulator HTH_6 PF01418.17 CAV27342.1 - 0.012 15.6 0.0 0.039 13.9 0.0 1.8 2 0 0 2 2 1 0 Helix-turn-helix domain, rpiR family Fe_dep_repress PF01325.19 CAV27342.1 - 0.015 15.5 0.0 0.047 13.9 0.0 1.8 2 0 0 2 2 1 0 Iron dependent repressor, N-terminal DNA binding domain Aminotran_MocR PF12897.7 CAV27342.1 - 0.016 14.0 0.0 0.021 13.6 0.0 1.3 1 0 0 1 1 1 0 Alanine-glyoxylate amino-transferase MarR PF01047.22 CAV27342.1 - 0.021 14.8 0.0 0.067 13.1 0.0 1.9 1 0 0 1 1 1 0 MarR family HTH_Crp_2 PF13545.6 CAV27342.1 - 0.032 14.2 0.0 0.084 12.9 0.0 1.7 1 0 0 1 1 1 0 Crp-like helix-turn-helix domain HTH_41 PF14502.6 CAV27342.1 - 0.034 13.8 0.0 0.12 12.1 0.0 2.0 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_Tnp_ISL3 PF13542.6 CAV27342.1 - 0.043 13.2 0.0 0.096 12.1 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain of transposase family ISL3 HTH_AsnC-type PF13404.6 CAV27342.1 - 0.052 13.4 0.0 0.052 13.4 0.0 1.8 2 0 0 2 2 1 0 AsnC-type helix-turn-helix domain RPA_C PF08784.11 CAV27342.1 - 0.055 14.1 0.0 0.14 12.9 0.0 1.6 1 0 0 1 1 1 0 Replication protein A C terminal HTH_DeoR PF08220.12 CAV27342.1 - 0.055 13.2 0.0 0.12 12.1 0.0 1.6 1 0 0 1 1 1 0 DeoR-like helix-turn-helix domain NUMOD1 PF07453.13 CAV27342.1 - 0.085 13.1 0.0 0.2 11.9 0.0 1.7 1 0 0 1 1 1 0 NUMOD1 domain HTH_23 PF13384.6 CAV27342.1 - 0.11 12.3 0.1 0.29 11.0 0.1 1.6 1 0 0 1 1 1 0 Homeodomain-like domain HTH_10 PF04967.12 CAV27342.1 - 0.14 12.0 0.0 0.38 10.6 0.0 1.8 1 0 0 1 1 1 0 HTH DNA binding domain Acetyltransf_7 PF13508.7 CAV27344.1 - 6.5e-08 32.9 0.0 1.1e-07 32.1 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 CAV27344.1 - 2.8e-07 30.8 0.0 3.4e-07 30.5 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_9 PF13527.7 CAV27344.1 - 6.1e-07 29.6 0.0 9.7e-07 28.9 0.0 1.3 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 CAV27344.1 - 0.00018 21.5 0.0 0.00034 20.5 0.0 1.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain MerR_1 PF13411.6 CAV27345.1 - 1.5e-16 60.2 0.1 3.3e-16 59.1 0.1 1.6 1 0 0 1 1 1 1 MerR HTH family regulatory protein Methyltransf_31 PF13847.6 CAV27345.1 - 2.3e-15 56.7 0.0 5e-15 55.6 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CAV27345.1 - 3.2e-15 56.6 0.0 1e-14 55.0 0.0 1.9 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CAV27345.1 - 4.3e-14 52.9 0.0 8.4e-14 52.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_24 PF13578.6 CAV27345.1 - 1.3e-12 48.7 0.1 6.6e-12 46.4 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain MerR PF00376.23 CAV27345.1 - 3.4e-12 45.9 0.9 6.2e-12 45.1 0.9 1.5 1 0 0 1 1 1 1 MerR family regulatory protein Methyltransf_23 PF13489.6 CAV27345.1 - 1.4e-08 34.7 0.0 3.3e-08 33.6 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CAV27345.1 - 1.7e-08 35.1 0.3 3.9e-08 33.9 0.0 1.8 2 0 0 2 2 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 CAV27345.1 - 2.1e-07 30.5 0.0 4.6e-07 29.4 0.0 1.5 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family MTS PF05175.14 CAV27345.1 - 9.4e-06 25.3 0.0 2e-05 24.2 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase small domain Glyco_hydro_53 PF07745.13 CAV27345.1 - 0.00018 20.6 0.2 0.00034 19.7 0.0 1.5 2 0 0 2 2 2 1 Glycosyl hydrolase family 53 Methyltransf_18 PF12847.7 CAV27345.1 - 0.00025 21.0 0.2 0.033 14.1 0.1 2.8 3 0 0 3 3 3 1 Methyltransferase domain PCMT PF01135.19 CAV27345.1 - 0.0011 18.8 0.0 0.0019 18.0 0.0 1.4 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) CMAS PF02353.20 CAV27345.1 - 0.0014 17.9 0.0 0.0022 17.4 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_33 PF10017.9 CAV27345.1 - 0.0017 17.6 0.0 0.0038 16.4 0.0 1.6 1 1 0 1 1 1 1 Histidine-specific methyltransferase, SAM-dependent UPF0020 PF01170.18 CAV27345.1 - 0.002 17.8 0.0 0.0041 16.8 0.0 1.5 1 0 0 1 1 1 1 Putative RNA methylase family UPF0020 Methyltransf_4 PF02390.17 CAV27345.1 - 0.0038 16.7 0.0 0.0076 15.7 0.0 1.4 1 0 0 1 1 1 1 Putative methyltransferase PrmA PF06325.13 CAV27345.1 - 0.0052 16.2 0.4 0.01 15.3 0.3 1.6 1 1 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) PRMT5 PF05185.16 CAV27345.1 - 0.0079 16.1 0.0 0.013 15.4 0.0 1.4 1 0 0 1 1 1 1 PRMT5 arginine-N-methyltransferase HTH_24 PF13412.6 CAV27345.1 - 0.012 15.2 0.2 0.39 10.3 0.0 3.0 3 0 0 3 3 3 0 Winged helix-turn-helix DNA-binding HTH_20 PF12840.7 CAV27345.1 - 0.012 15.6 2.0 1.2 9.2 1.0 2.8 2 0 0 2 2 2 0 Helix-turn-helix domain Methyltransf_32 PF13679.6 CAV27345.1 - 0.013 15.5 0.0 0.03 14.3 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain HTH_17 PF12728.7 CAV27345.1 - 0.014 15.6 0.9 0.024 14.8 0.2 1.8 2 0 0 2 2 1 0 Helix-turn-helix domain Methyltransf_3 PF01596.17 CAV27345.1 - 0.014 14.5 0.1 0.034 13.3 0.0 1.6 1 1 0 1 1 1 0 O-methyltransferase RrnaAD PF00398.20 CAV27345.1 - 0.045 12.8 0.0 0.083 11.9 0.0 1.4 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase HTH_5 PF01022.20 CAV27345.1 - 0.11 12.4 0.5 4.6 7.2 0.0 3.1 3 0 0 3 3 3 0 Bacterial regulatory protein, arsR family HTH_8 PF02954.19 CAV27345.1 - 0.11 12.3 0.4 0.41 10.5 0.0 2.2 2 0 0 2 2 1 0 Bacterial regulatory protein, Fis family CheR PF01739.18 CAV27345.1 - 0.11 11.9 0.0 0.23 10.9 0.0 1.5 1 0 0 1 1 1 0 CheR methyltransferase, SAM binding domain TehB PF03848.14 CAV27345.1 - 0.13 11.7 0.0 0.26 10.7 0.0 1.4 1 0 0 1 1 1 0 Tellurite resistance protein TehB Golgin_A5 PF09787.9 CAV27345.1 - 0.25 10.8 2.4 0.24 10.8 0.6 1.9 2 1 1 3 3 3 0 Golgin subfamily A member 5 MerR-DNA-bind PF09278.11 CAV27345.1 - 1.4 9.5 10.2 1.1 9.8 8.1 2.0 2 0 0 2 2 1 0 MerR, DNA binding Trp_Tyr_perm PF03222.13 CAV27347.1 - 5.5e-68 229.8 38.2 6.3e-68 229.6 38.2 1.0 1 0 0 1 1 1 1 Tryptophan/tyrosine permease family Aa_trans PF01490.18 CAV27347.1 - 4.5e-08 32.2 36.8 1.5e-07 30.5 36.8 1.8 1 1 0 1 1 1 1 Transmembrane amino acid transporter protein AA_permease_2 PF13520.6 CAV27347.1 - 6.4e-07 28.5 44.1 1.3e-05 24.2 44.1 2.0 1 1 0 1 1 1 1 Amino acid permease MarR PF01047.22 CAV27349.1 - 2.4e-14 53.0 0.0 4.1e-14 52.2 0.0 1.4 1 0 0 1 1 1 1 MarR family MarR_2 PF12802.7 CAV27349.1 - 4.8e-08 32.8 0.0 7e-08 32.3 0.0 1.3 1 0 0 1 1 1 1 MarR family HTH_34 PF13601.6 CAV27349.1 - 1.5e-05 25.1 0.6 3.7e-05 23.8 0.1 1.8 2 0 0 2 2 2 1 Winged helix DNA-binding domain HTH_27 PF13463.6 CAV27349.1 - 2.2e-05 24.8 0.4 4.9e-05 23.8 0.2 1.7 2 0 0 2 2 2 1 Winged helix DNA-binding domain Penicillinase_R PF03965.16 CAV27349.1 - 0.00039 20.7 3.0 0.00053 20.3 0.4 2.1 2 0 0 2 2 2 1 Penicillinase repressor PadR PF03551.14 CAV27349.1 - 0.0016 18.3 0.1 0.0026 17.7 0.1 1.3 1 0 0 1 1 1 1 Transcriptional regulator PadR-like family HTH_24 PF13412.6 CAV27349.1 - 0.012 15.1 0.0 0.023 14.3 0.0 1.3 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding TrmB PF01978.19 CAV27349.1 - 0.086 12.7 0.1 0.17 11.8 0.1 1.5 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB OsmC PF02566.19 CAV27351.1 - 5.4e-19 68.5 0.1 7.1e-19 68.1 0.1 1.1 1 0 0 1 1 1 1 OsmC-like protein NIT PF08376.10 CAV27352.1 - 3.3e-51 175.0 0.6 3.3e-51 175.0 0.6 3.3 2 1 1 3 3 3 1 Nitrate and nitrite sensing MCPsignal PF00015.21 CAV27352.1 - 7.4e-45 152.8 49.2 7.1e-43 146.4 22.3 5.1 2 1 4 6 6 6 5 Methyl-accepting chemotaxis protein (MCP) signalling domain HAMP PF00672.25 CAV27352.1 - 2.3e-05 24.7 1.1 0.00018 21.8 0.0 3.2 3 0 0 3 3 3 1 HAMP domain DUF1664 PF07889.12 CAV27352.1 - 1.4 9.0 30.0 0.28 11.2 1.3 5.3 4 2 2 6 6 6 0 Protein of unknown function (DUF1664) RPW8 PF05659.11 CAV27352.1 - 2 8.1 10.7 6.3 6.5 0.2 4.7 5 1 1 6 6 6 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 DASH_Dam1 PF08653.10 CAV27352.1 - 2.1 8.2 5.4 13 5.7 0.1 4.5 5 0 0 5 5 5 0 DASH complex subunit Dam1 BLOC1_2 PF10046.9 CAV27352.1 - 7.5 6.9 28.5 2.7 8.4 1.0 6.8 4 2 3 7 7 7 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 zinc_ribbon_10 PF10058.9 CAV27354.1 - 0.008 15.9 0.4 0.01 15.5 0.4 1.2 1 0 0 1 1 1 1 Predicted integral membrane zinc-ribbon metal-binding protein DNA_ligase_ZBD PF03119.16 CAV27354.1 - 0.015 15.3 0.4 3.8 7.6 0.0 2.3 2 0 0 2 2 2 0 NAD-dependent DNA ligase C4 zinc finger domain zf-RRN7 PF11781.8 CAV27354.1 - 0.021 14.5 2.8 0.043 13.5 0.3 2.1 2 0 0 2 2 2 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 zinc-ribbons_6 PF07191.12 CAV27354.1 - 0.035 14.1 1.5 0.064 13.2 1.5 1.4 1 1 0 1 1 1 0 zinc-ribbons zf-LITAF-like PF10601.9 CAV27354.1 - 0.058 13.7 0.3 6.9 7.0 0.0 2.1 2 0 0 2 2 2 0 LITAF-like zinc ribbon domain zf-ACC PF17848.1 CAV27354.1 - 0.085 12.9 2.2 2.5 8.3 0.1 2.3 2 0 0 2 2 2 0 Acetyl-coA carboxylase zinc finger domain Zn_Tnp_IS1595 PF12760.7 CAV27354.1 - 0.097 12.7 2.0 0.71 9.9 0.0 2.1 1 1 1 2 2 2 0 Transposase zinc-ribbon domain YacG PF03884.14 CAV27354.1 - 0.13 12.1 4.1 5.8 6.7 1.4 2.5 2 1 0 2 2 2 0 DNA gyrase inhibitor YacG Anti-TRAP PF15777.5 CAV27354.1 - 0.14 12.1 3.9 1.1 9.3 3.9 2.0 1 1 0 1 1 1 0 Tryptophan RNA-binding attenuator protein inhibitory protein UPF0547 PF10571.9 CAV27354.1 - 0.19 11.9 4.1 4.2 7.6 0.8 2.3 2 0 0 2 2 2 0 Uncharacterised protein family UPF0547 zf-C4_Topoisom PF01396.19 CAV27354.1 - 0.25 11.1 5.0 1.8 8.4 0.5 2.3 2 1 0 2 2 2 0 Topoisomerase DNA binding C4 zinc finger zf-RING_4 PF14570.6 CAV27354.1 - 0.49 10.2 5.9 0.46 10.3 0.5 2.1 1 1 1 2 2 2 0 RING/Ubox like zinc-binding domain TetR_N PF00440.23 CAV27356.1 - 8.3e-11 41.5 0.0 1.7e-10 40.5 0.0 1.6 1 0 0 1 1 1 1 Bacterial regulatory proteins, tetR family TetR_C_13 PF16925.5 CAV27356.1 - 1.5e-05 24.9 0.1 2.1e-05 24.4 0.1 1.2 1 0 0 1 1 1 1 Tetracyclin repressor-like, C-terminal domain CBF PF03914.17 CAV27356.1 - 0.016 15.2 0.0 0.019 15.0 0.0 1.2 1 0 0 1 1 1 0 CBF/Mak21 family ApoLp-III PF07464.11 CAV27356.1 - 0.023 14.8 0.1 0.034 14.2 0.1 1.3 1 0 0 1 1 1 0 Apolipophorin-III precursor (apoLp-III) PTS_EIIA_2 PF00359.22 CAV27358.1 - 1.5e-33 115.8 0.0 2.5e-33 115.0 0.0 1.4 1 0 0 1 1 1 1 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 PTS_IIB PF02302.17 CAV27358.1 - 3.1e-16 59.8 0.3 6.5e-16 58.8 0.3 1.6 1 0 0 1 1 1 1 PTS system, Lactose/Cellobiose specific IIB subunit PTS_EIIC PF02378.18 CAV27358.1 - 1.1e-14 54.2 30.4 1.1e-14 54.2 30.4 2.3 1 1 1 2 2 2 1 Phosphotransferase system, EIIC DUF4257 PF14074.6 CAV27358.1 - 4.8 7.5 12.8 1.7 8.9 2.2 3.1 2 1 0 2 2 2 0 Protein of unknown function (DUF4257) PTS_IIB PF02302.17 CAV27360.1 - 4.7e-13 49.7 0.2 5.1e-13 49.5 0.2 1.0 1 0 0 1 1 1 1 PTS system, Lactose/Cellobiose specific IIB subunit PTS_EIIA_2 PF00359.22 CAV27362.1 - 2.1e-22 79.6 0.5 8.6e-22 77.6 0.1 1.9 2 0 0 2 2 2 1 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 PTS-HPr PF00381.19 CAV27362.1 - 0.00012 22.3 0.1 0.00022 21.4 0.1 1.4 1 0 0 1 1 1 1 PTS HPr component phosphorylation site HTH_18 PF12833.7 CAV27363.1 - 3.2e-21 75.4 1.4 1.6e-20 73.1 0.6 2.2 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_AraC PF00165.23 CAV27363.1 - 1.5e-17 63.2 1.4 5.5e-12 45.5 0.0 2.6 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family Cupin_2 PF07883.11 CAV27363.1 - 0.19 11.4 0.0 0.34 10.6 0.0 1.4 1 0 0 1 1 1 0 Cupin domain PTS_EIIA_2 PF00359.22 CAV27365.1 - 7.7e-36 123.1 0.1 1.4e-35 122.3 0.1 1.4 1 0 0 1 1 1 1 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 PTS_IIB PF02302.17 CAV27365.1 - 1.8e-16 60.6 0.8 3.8e-16 59.6 0.8 1.6 1 0 0 1 1 1 1 PTS system, Lactose/Cellobiose specific IIB subunit PTS_EIIC PF02378.18 CAV27365.1 - 1.9e-14 53.4 39.3 1.9e-14 53.4 39.3 2.5 2 1 1 3 3 3 1 Phosphotransferase system, EIIC PMI_typeI PF01238.21 CAV27367.1 - 2.1e-85 287.2 0.1 9e-85 285.1 0.1 1.8 1 1 0 1 1 1 1 Phosphomannose isomerase type I Cupin_2 PF07883.11 CAV27367.1 - 0.0012 18.5 0.0 0.47 10.2 0.0 2.6 2 0 0 2 2 2 2 Cupin domain PTS_EIIA_2 PF00359.22 CAV27369.1 - 3.2e-29 101.7 0.2 3.6e-29 101.5 0.2 1.0 1 0 0 1 1 1 1 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 PTS_IIB PF02302.17 CAV27371.1 - 3.4e-16 59.7 3.4 7.1e-16 58.7 3.4 1.6 1 0 0 1 1 1 1 PTS system, Lactose/Cellobiose specific IIB subunit ATP-synt_J PF04911.12 CAV27371.1 - 1.4 8.6 7.3 4.3 7.0 0.1 4.1 4 0 0 4 4 4 0 ATP synthase j chain SBP_bac_5 PF00496.22 CAV27373.1 - 2.2e-81 273.8 6.9 3e-81 273.3 6.9 1.2 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 5 Middle Peptidase_M14 PF00246.24 CAV27376.1 - 6.7e-12 45.8 0.1 1.6e-11 44.6 0.1 1.5 1 1 0 1 1 1 1 Zinc carboxypeptidase AstE_AspA PF04952.14 CAV27376.1 - 6e-09 35.4 0.0 2.8e-08 33.2 0.1 1.8 2 0 0 2 2 2 1 Succinylglutamate desuccinylase / Aspartoacylase family DUF2817 PF10994.8 CAV27376.1 - 0.023 14.1 0.0 0.029 13.8 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2817) CoiA PF06054.11 CAV27379.1 - 4.6e-07 29.3 1.2 1.1e-06 28.1 1.2 1.6 1 0 0 1 1 1 1 Competence protein CoiA-like family AalphaY_MDB PF04611.12 CAV27379.1 - 0.1 12.6 0.1 0.2 11.6 0.1 1.4 1 0 0 1 1 1 0 Mating type protein A alpha Y mating type dependent binding region ADH_zinc_N PF00107.26 CAV27381.1 - 1.1e-25 90.0 0.1 2e-25 89.3 0.1 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 CAV27381.1 - 3.3e-25 88.1 1.1 3.3e-25 88.1 1.1 1.8 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.6 CAV27381.1 - 0.00035 21.6 0.0 0.00073 20.6 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 CAV27381.1 - 0.00062 19.3 0.0 0.0017 17.9 0.0 1.7 1 1 0 1 1 1 1 Glucose dehydrogenase C-terminus UDPG_MGDP_dh_N PF03721.14 CAV27381.1 - 0.011 15.4 0.1 0.021 14.4 0.1 1.5 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain AlaDh_PNT_C PF01262.21 CAV27381.1 - 0.09 12.1 0.6 0.15 11.3 0.6 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Esterase PF00756.20 CAV27384.1 - 4.9e-59 200.0 0.0 5.8e-59 199.8 0.0 1.0 1 0 0 1 1 1 1 Putative esterase Hydrolase_4 PF12146.8 CAV27384.1 - 3.1e-06 26.6 0.0 1e-05 24.9 0.0 1.7 1 1 1 2 2 2 2 Serine aminopeptidase, S33 Peptidase_S9 PF00326.21 CAV27384.1 - 0.00019 21.0 0.0 0.0003 20.3 0.0 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family Chlorophyllase2 PF12740.7 CAV27384.1 - 0.007 15.3 0.0 0.01 14.8 0.0 1.2 1 0 0 1 1 1 1 Chlorophyllase enzyme DLH PF01738.18 CAV27384.1 - 0.026 14.1 0.0 0.039 13.5 0.0 1.4 1 0 0 1 1 1 0 Dienelactone hydrolase family Esterase_phd PF10503.9 CAV27384.1 - 0.13 11.7 0.0 0.6 9.5 0.0 1.9 2 0 0 2 2 2 0 Esterase PHB depolymerase Multi_Drug_Res PF00893.19 CAV27387.1 - 9.4e-17 61.5 6.6 9.4e-17 61.5 6.6 1.3 1 1 0 1 1 1 1 Small Multidrug Resistance protein EamA PF00892.20 CAV27387.1 - 5.2e-05 23.4 9.9 5.9e-05 23.3 9.9 1.1 1 0 0 1 1 1 1 EamA-like transporter family Nuc_sug_transp PF04142.15 CAV27387.1 - 0.0095 15.1 1.4 0.012 14.8 1.3 1.3 1 1 0 1 1 1 1 Nucleotide-sugar transporter TMEM234 PF10639.9 CAV27387.1 - 0.013 15.6 1.3 0.014 15.4 1.3 1.2 1 0 0 1 1 1 0 Putative transmembrane family 234 EmrE PF13536.6 CAV27387.1 - 0.014 15.0 4.3 0.015 14.9 4.3 1.2 1 0 0 1 1 1 0 Putative multidrug resistance efflux transporter TMEM100 PF16311.5 CAV27387.1 - 0.031 13.9 1.9 0.048 13.2 1.9 1.2 1 0 0 1 1 1 0 Transmembrane protein 100 DUF2545 PF10810.8 CAV27387.1 - 0.22 11.7 6.6 3.1 8.0 1.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2545) NUDIX PF00293.28 CAV27391.1 - 5e-21 75.1 0.0 8.9e-21 74.3 0.0 1.4 1 0 0 1 1 1 1 NUDIX domain Nudix_hydro PF18290.1 CAV27391.1 - 2.4e-18 65.9 0.0 4.4e-18 65.1 0.0 1.4 1 0 0 1 1 1 1 Nudix hydrolase domain LysE PF01810.18 CAV27394.1 - 1.4e-30 106.2 11.6 1.8e-30 105.9 11.6 1.1 1 0 0 1 1 1 1 LysE type translocator LysR_substrate PF03466.20 CAV27397.1 - 3.2e-22 78.9 0.0 6e-22 78.0 0.0 1.4 1 0 0 1 1 1 1 LysR substrate binding domain HTH_1 PF00126.27 CAV27397.1 - 1.4e-16 60.1 0.4 2.8e-16 59.2 0.4 1.5 1 0 0 1 1 1 1 Bacterial regulatory helix-turn-helix protein, lysR family HTH_28 PF13518.6 CAV27397.1 - 0.02 15.0 0.0 0.039 14.1 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_30 PF13556.6 CAV27397.1 - 0.045 13.6 0.0 0.09 12.6 0.0 1.5 1 0 0 1 1 1 0 PucR C-terminal helix-turn-helix domain P22_Cro PF14549.6 CAV27397.1 - 0.046 13.6 0.3 0.11 12.4 0.3 1.6 1 0 0 1 1 1 0 DNA-binding transcriptional regulator Cro Aldedh PF00171.22 CAV27400.1 - 2.3e-166 553.9 0.1 2.6e-166 553.7 0.1 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Sigma54_activat PF00158.26 CAV27406.1 - 6.5e-61 204.9 0.1 1.1e-60 204.1 0.1 1.4 1 0 0 1 1 1 1 Sigma-54 interaction domain Sigma54_activ_2 PF14532.6 CAV27406.1 - 3.5e-18 66.1 0.0 1.7e-17 63.9 0.0 2.2 1 1 0 1 1 1 1 Sigma-54 interaction domain GAF PF01590.26 CAV27406.1 - 2.4e-09 37.9 0.1 5.6e-09 36.7 0.1 1.7 1 0 0 1 1 1 1 GAF domain HTH_8 PF02954.19 CAV27406.1 - 1.6e-08 34.2 0.1 3.4e-08 33.1 0.1 1.5 1 0 0 1 1 1 1 Bacterial regulatory protein, Fis family HTH_30 PF13556.6 CAV27406.1 - 1.5e-05 24.7 0.0 3.2e-05 23.6 0.0 1.5 1 0 0 1 1 1 1 PucR C-terminal helix-turn-helix domain Mg_chelatase PF01078.21 CAV27406.1 - 8.1e-05 22.1 0.0 0.00043 19.7 0.0 2.0 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA PF00004.29 CAV27406.1 - 0.00012 22.5 0.0 0.00048 20.6 0.0 2.1 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 CAV27406.1 - 0.0005 20.1 0.0 0.0016 18.5 0.0 1.9 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.11 CAV27406.1 - 0.00055 19.8 0.1 0.018 14.9 0.0 2.8 3 0 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) PAS_4 PF08448.10 CAV27406.1 - 0.0016 18.7 0.0 0.054 13.8 0.0 2.8 2 0 0 2 2 2 1 PAS fold HTH_7 PF02796.15 CAV27406.1 - 0.0021 18.1 0.3 0.0056 16.7 0.3 1.8 1 0 0 1 1 1 1 Helix-turn-helix domain of resolvase AAA_2 PF07724.14 CAV27406.1 - 0.0035 17.5 1.6 0.0068 16.5 0.1 2.3 3 1 0 3 3 2 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.6 CAV27406.1 - 0.0054 17.0 1.7 0.19 12.0 0.1 3.2 2 1 0 2 2 2 1 AAA domain MCM PF00493.23 CAV27406.1 - 0.0057 15.8 0.1 0.092 11.8 0.1 2.2 1 1 0 1 1 1 1 MCM P-loop domain Diacid_rec PF05651.13 CAV27406.1 - 0.013 15.2 0.0 6.9 6.4 0.0 2.8 2 0 0 2 2 2 0 Putative sugar diacid recognition IclR PF01614.18 CAV27406.1 - 0.013 15.3 0.0 0.063 13.1 0.0 2.0 2 0 0 2 2 2 0 Bacterial transcriptional regulator HTH_22 PF13309.6 CAV27406.1 - 0.018 15.1 0.0 0.048 13.7 0.0 1.8 1 0 0 1 1 1 0 HTH domain NUMOD1 PF07453.13 CAV27406.1 - 0.036 14.3 0.3 0.07 13.4 0.3 1.5 1 0 0 1 1 1 0 NUMOD1 domain HTH_Tnp_IS1 PF12759.7 CAV27406.1 - 0.05 13.2 0.2 0.097 12.3 0.2 1.5 1 0 0 1 1 1 0 InsA C-terminal domain HTH_50 PF18024.1 CAV27406.1 - 0.053 13.1 0.1 0.13 11.8 0.1 1.7 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_28 PF13518.6 CAV27406.1 - 0.055 13.6 0.0 0.13 12.4 0.0 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_23 PF13384.6 CAV27406.1 - 0.06 13.2 0.0 0.17 11.7 0.0 1.7 1 0 0 1 1 1 0 Homeodomain-like domain DUF2089 PF09862.9 CAV27406.1 - 0.081 13.0 0.0 0.24 11.4 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2089) PAS_9 PF13426.7 CAV27406.1 - 0.13 12.6 0.0 7.8 6.8 0.0 3.1 3 0 0 3 3 3 0 PAS domain DUF1727 PF08353.10 CAV27406.1 - 0.14 12.1 0.0 0.33 10.9 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF1727) MCPsignal PF00015.21 CAV27409.1 - 2.9e-42 144.4 55.4 3e-41 141.1 26.1 4.0 4 0 0 4 4 4 2 Methyl-accepting chemotaxis protein (MCP) signalling domain HAMP PF00672.25 CAV27409.1 - 1.1e-10 41.7 0.2 5.1e-07 30.0 0.0 3.6 2 0 0 2 2 2 2 HAMP domain Archease PF01951.16 CAV27409.1 - 0.047 13.9 0.4 0.19 12.0 0.4 2.1 1 0 0 1 1 1 0 Archease protein family (MTH1598/TM1083) T3SSipB PF16535.5 CAV27409.1 - 1.1 9.7 30.2 0.075 13.5 2.8 3.6 3 0 0 3 3 3 0 Type III cell invasion protein SipB ISG65-75 PF11727.8 CAV27409.1 - 1.5 8.0 25.4 3.2 6.9 0.7 3.3 3 0 0 3 3 3 0 Invariant surface glycoprotein RPW8 PF05659.11 CAV27409.1 - 3.2 7.4 8.4 0.57 9.9 0.8 3.3 3 2 1 4 4 4 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 ING PF12998.7 CAV27409.1 - 3.5 8.3 8.8 6.3 7.5 3.2 3.1 2 1 0 2 2 2 0 Inhibitor of growth proteins N-terminal histone-binding Muted PF14942.6 CAV27409.1 - 4 7.8 26.0 0.034 14.5 7.1 3.8 3 1 0 3 3 3 0 Organelle biogenesis, Muted-like protein GvpG PF05120.12 CAV27409.1 - 5.4 7.1 8.3 15 5.7 0.0 3.9 2 1 1 3 3 3 0 Gas vesicle protein G Troponin PF00992.20 CAV27409.1 - 6 7.2 9.4 1.1 9.6 2.4 2.8 2 1 0 2 2 2 0 Troponin APG6_N PF17675.1 CAV27409.1 - 7.7 7.0 12.0 1.9 9.0 3.8 3.0 2 0 0 2 2 2 0 Apg6 coiled-coil region HTH_1 PF00126.27 CAV27410.1 - 4.9e-19 68.0 1.0 1.1e-18 66.9 1.0 1.7 1 0 0 1 1 1 1 Bacterial regulatory helix-turn-helix protein, lysR family LysR_substrate PF03466.20 CAV27410.1 - 1.8e-18 66.7 0.0 3.1e-18 65.9 0.0 1.4 1 0 0 1 1 1 1 LysR substrate binding domain HTH_34 PF13601.6 CAV27410.1 - 0.064 13.4 0.1 0.13 12.5 0.1 1.5 1 0 0 1 1 1 0 Winged helix DNA-binding domain GST_N_3 PF13417.6 CAV27412.1 - 3.9e-08 33.6 0.0 7.9e-08 32.6 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_4 PF14834.6 CAV27412.1 - 4e-08 33.7 0.2 7.3e-08 32.8 0.2 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 CAV27412.1 - 7.3e-08 32.6 0.1 1.9e-07 31.3 0.0 1.8 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 CAV27412.1 - 3e-07 30.7 0.1 5.8e-07 29.7 0.1 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 CAV27412.1 - 0.0012 18.9 0.1 0.0027 17.7 0.0 1.8 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 CAV27412.1 - 0.0014 18.7 0.0 0.0047 17.1 0.0 1.8 1 1 1 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 CAV27412.1 - 0.0059 16.8 0.0 0.01 16.0 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain DUF4219 PF13961.6 CAV27412.1 - 0.083 12.6 0.7 2.6 7.8 0.2 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4219) HTH_26 PF13443.6 CAV27414.1 - 5.6e-23 81.1 0.4 6.4e-23 81.0 0.4 1.0 1 0 0 1 1 1 1 Cro/C1-type HTH DNA-binding domain HTH_3 PF01381.22 CAV27414.1 - 5.6e-05 23.1 0.0 7e-05 22.8 0.0 1.1 1 0 0 1 1 1 1 Helix-turn-helix HTH_19 PF12844.7 CAV27414.1 - 0.00025 21.0 0.0 0.0003 20.7 0.0 1.1 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_37 PF13744.6 CAV27414.1 - 0.0043 17.0 0.2 0.0051 16.7 0.2 1.1 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_31 PF13560.6 CAV27414.1 - 0.0052 17.1 0.0 0.0061 16.9 0.0 1.1 1 0 0 1 1 1 1 Helix-turn-helix domain FliMN_C PF01052.20 CAV27414.1 - 0.08 13.0 0.1 2.6 8.1 0.0 2.4 2 1 0 2 2 2 0 Type III flagellar switch regulator (C-ring) FliN C-term HTH_Mga PF08280.11 CAV27414.1 - 0.11 12.6 0.3 10 6.2 0.0 2.2 2 0 0 2 2 2 0 M protein trans-acting positive regulator (MGA) HTH domain RIIa PF02197.17 CAV27414.1 - 0.13 12.0 0.0 0.21 11.3 0.0 1.3 1 0 0 1 1 1 0 Regulatory subunit of type II PKA R-subunit DUF2975 PF11188.8 CAV27416.1 - 2.1e-14 53.5 7.6 2.6e-13 50.0 7.0 2.1 1 1 1 2 2 2 2 Protein of unknown function (DUF2975) Sel1 PF08238.12 CAV27419.1 - 0.015 15.9 0.0 0.11 13.2 0.1 2.2 2 0 0 2 2 2 0 Sel1 repeat Flavin_Reduct PF01613.18 CAV27421.1 - 3.9e-14 53.0 0.0 5.3e-14 52.5 0.0 1.1 1 0 0 1 1 1 1 Flavin reductase like domain LPD1 PF18796.1 CAV27423.1 - 2.8e-19 69.0 0.2 6.7e-19 67.8 0.0 1.7 2 0 0 2 2 2 1 Large polyvalent protein-associated domain 1 GMP_synt_C PF00958.22 CAV27423.1 - 0.049 13.7 0.0 0.082 13.0 0.0 1.3 1 0 0 1 1 1 0 GMP synthase C terminal domain CAP160 PF07918.11 CAV27423.1 - 0.12 12.2 0.3 0.32 10.8 0.3 1.7 1 0 0 1 1 1 0 CAP160 repeat DUF4144 PF13642.6 CAV27424.1 - 3.2e-36 123.9 0.2 3.6e-36 123.8 0.2 1.0 1 0 0 1 1 1 1 protein structure with unknown function RVT_1 PF00078.27 CAV27426.1 - 0.036 13.6 0.0 0.038 13.5 0.0 1.2 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) DUF3220 PF11516.8 CAV27428.1 - 0.0086 16.3 0.0 0.027 14.7 0.0 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF3120) OEP PF02321.18 CAV27428.1 - 0.094 12.5 2.2 0.23 11.2 1.7 2.0 2 0 0 2 2 2 0 Outer membrane efflux protein DcuA_DcuB PF03605.14 CAV27431.1 - 4e-151 503.1 20.1 5e-151 502.8 20.1 1.1 1 0 0 1 1 1 1 Anaerobic c4-dicarboxylate membrane transporter DcuC PF03606.15 CAV27431.1 - 4.1e-06 25.5 18.4 9.8e-05 21.0 18.4 2.1 1 1 0 1 1 1 1 C4-dicarboxylate anaerobic carrier Hum_adeno_E3A PF05393.11 CAV27431.1 - 0.62 10.1 4.9 1.6 8.8 0.0 3.1 3 0 0 3 3 3 0 Human adenovirus early E3A glycoprotein HAD_2 PF13419.6 CAV27433.1 - 2.9e-32 112.2 0.0 3.5e-32 111.9 0.0 1.1 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 CAV27433.1 - 1.7e-21 77.5 0.1 1.3e-19 71.3 0.0 2.5 2 1 0 2 2 2 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 CAV27433.1 - 1.2e-05 25.8 0.0 1.6e-05 25.4 0.0 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 CAV27433.1 - 0.00011 22.2 0.0 0.0002 21.4 0.0 1.4 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase_6 PF13344.6 CAV27433.1 - 0.12 12.4 0.0 4.4 7.5 0.0 2.6 2 1 0 2 2 2 0 Haloacid dehalogenase-like hydrolase HD PF01966.22 CAV27436.1 - 5.7e-10 39.5 0.3 1e-09 38.7 0.3 1.4 1 0 0 1 1 1 1 HD domain Acetyltransf_1 PF00583.25 CAV27437.1 - 8e-12 45.4 0.0 1.1e-11 45.0 0.0 1.3 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 CAV27437.1 - 4.9e-11 42.7 0.0 1.4e-10 41.2 0.0 1.6 1 1 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.7 CAV27437.1 - 1e-08 36.0 0.0 1.3e-08 35.6 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 CAV27437.1 - 4.2e-07 30.3 0.0 5.8e-07 29.9 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 CAV27437.1 - 3.4e-05 23.9 0.0 5.8e-05 23.1 0.0 1.3 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase Acetyltransf_4 PF13420.7 CAV27437.1 - 0.00028 21.1 0.0 0.00074 19.7 0.0 1.7 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 CAV27437.1 - 0.00032 20.6 0.0 0.00087 19.2 0.0 1.7 1 1 1 2 2 2 1 FR47-like protein Acetyltransf_9 PF13527.7 CAV27437.1 - 0.027 14.5 0.0 0.046 13.8 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.6 CAV27437.1 - 0.038 13.7 0.0 0.13 11.9 0.0 1.9 2 1 0 2 2 2 0 Acetyltransferase (GNAT) domain Adenine_glyco PF03352.13 CAV27439.1 - 2e-14 53.8 0.3 4.4e-14 52.7 0.2 1.5 1 1 1 2 2 2 1 Methyladenine glycosylase Cnd1_N PF12922.7 CAV27439.1 - 0.11 12.3 0.3 2.9 7.7 0.0 2.1 2 0 0 2 2 2 0 non-SMC mitotic condensation complex subunit 1, N-term Mem_trans PF03547.18 CAV27441.1 - 3e-15 55.5 29.2 3.7e-10 38.8 15.6 2.1 1 1 1 2 2 2 2 Membrane transport protein MarR PF01047.22 CAV27450.1 - 2.8e-13 49.6 0.1 6.8e-13 48.3 0.1 1.7 1 0 0 1 1 1 1 MarR family MarR_2 PF12802.7 CAV27450.1 - 7.4e-13 48.2 0.0 1.4e-12 47.3 0.0 1.5 1 0 0 1 1 1 1 MarR family HTH_27 PF13463.6 CAV27450.1 - 8.6e-09 35.8 0.1 2e-08 34.6 0.1 1.7 1 0 0 1 1 1 1 Winged helix DNA-binding domain HTH_34 PF13601.6 CAV27450.1 - 7.3e-05 22.9 0.1 0.00012 22.1 0.1 1.5 1 0 0 1 1 1 1 Winged helix DNA-binding domain HxlR PF01638.17 CAV27450.1 - 0.0082 16.0 0.1 0.015 15.1 0.1 1.5 1 0 0 1 1 1 1 HxlR-like helix-turn-helix Rio2_N PF09202.11 CAV27450.1 - 0.015 15.5 0.1 0.17 12.1 0.0 2.2 2 1 0 2 2 2 0 Rio2, N-terminal HTH_24 PF13412.6 CAV27450.1 - 0.019 14.5 0.0 0.054 13.1 0.0 1.8 2 0 0 2 2 2 0 Winged helix-turn-helix DNA-binding LexA_DNA_bind PF01726.16 CAV27450.1 - 0.046 13.5 0.0 0.11 12.3 0.0 1.6 1 0 0 1 1 1 0 LexA DNA binding domain LTXXQ PF07813.12 CAV27450.1 - 1.3 9.7 7.9 0.42 11.4 1.1 2.3 2 1 0 2 2 2 0 LTXXQ motif family protein EamA PF00892.20 CAV27452.1 - 1.6e-20 73.7 35.2 3.1e-13 50.1 16.5 2.2 2 0 0 2 2 2 2 EamA-like transporter family MFS_1 PF07690.16 CAV27453.1 - 8.6e-23 80.8 42.1 3.4e-22 78.9 33.0 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_3 PF05977.13 CAV27453.1 - 2.7e-13 49.2 18.9 4.3e-13 48.5 18.9 1.2 1 0 0 1 1 1 1 Transmembrane secretion effector MFS_2 PF13347.6 CAV27453.1 - 8.3e-05 21.3 34.5 0.01 14.4 17.7 2.3 1 1 1 2 2 2 2 MFS/sugar transport protein TM_helix PF05552.12 CAV27453.1 - 2.8 8.0 8.1 16 5.6 0.0 3.9 3 0 0 3 3 3 0 Conserved TM helix SgrR_N PF12793.7 CAV27455.1 - 2.8e-21 75.9 0.1 9.1e-21 74.2 0.1 1.8 1 0 0 1 1 1 1 Sugar transport-related sRNA regulator N-term SBP_bac_5 PF00496.22 CAV27455.1 - 4.5e-19 68.7 0.0 1.3e-18 67.1 0.0 1.7 1 1 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 5 Middle MarR_2 PF12802.7 CAV27455.1 - 0.014 15.3 0.0 0.046 13.6 0.0 1.9 1 0 0 1 1 1 0 MarR family MarR PF01047.22 CAV27455.1 - 0.017 15.0 0.0 0.093 12.7 0.0 2.3 1 0 0 1 1 1 0 MarR family HTH_36 PF13730.6 CAV27455.1 - 0.038 13.9 0.1 0.1 12.6 0.1 1.7 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_IclR PF09339.10 CAV27455.1 - 0.17 11.7 0.1 0.66 9.8 0.0 2.1 3 0 0 3 3 3 0 IclR helix-turn-helix domain Ribonuc_L-PSP PF01042.21 CAV27457.1 - 3.7e-14 52.8 0.0 4.2e-14 52.6 0.0 1.0 1 0 0 1 1 1 1 Endoribonuclease L-PSP ABM PF03992.16 CAV27459.1 - 3.8e-11 42.9 0.1 5.2e-11 42.5 0.1 1.1 1 0 0 1 1 1 1 Antibiotic biosynthesis monooxygenase Imm51 PF15595.6 CAV27459.1 - 0.0084 16.0 0.0 0.011 15.7 0.0 1.1 1 0 0 1 1 1 1 Immunity protein 51 LysR_substrate PF03466.20 CAV27460.1 - 1.4e-34 119.4 0.0 2.5e-34 118.5 0.0 1.4 2 0 0 2 2 2 1 LysR substrate binding domain HTH_1 PF00126.27 CAV27460.1 - 3.3e-20 71.8 0.6 5.4e-20 71.1 0.6 1.4 1 0 0 1 1 1 1 Bacterial regulatory helix-turn-helix protein, lysR family HTH_5 PF01022.20 CAV27460.1 - 0.0045 16.8 0.3 0.023 14.6 0.3 2.2 2 0 0 2 2 2 1 Bacterial regulatory protein, arsR family HTH_30 PF13556.6 CAV27460.1 - 0.0065 16.3 0.0 0.014 15.2 0.0 1.5 1 0 0 1 1 1 1 PucR C-terminal helix-turn-helix domain HTH_20 PF12840.7 CAV27460.1 - 0.007 16.4 0.8 0.023 14.7 0.1 2.1 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_IclR PF09339.10 CAV27460.1 - 0.022 14.5 0.1 0.064 13.1 0.0 1.8 1 1 0 1 1 1 0 IclR helix-turn-helix domain EamA PF00892.20 CAV27462.1 - 8.8e-40 136.0 42.2 3.3e-24 85.6 21.1 2.0 2 0 0 2 2 2 2 EamA-like transporter family HTH_18 PF12833.7 CAV27466.1 - 1.8e-18 66.6 0.1 3.8e-18 65.5 0.1 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 CAV27466.1 - 5.7e-06 26.3 0.1 2.1e-05 24.5 0.1 1.9 2 0 0 2 2 2 1 Bacterial regulatory helix-turn-helix proteins, AraC family AraC_binding PF02311.19 CAV27466.1 - 0.15 12.0 0.0 0.25 11.3 0.0 1.4 1 0 0 1 1 1 0 AraC-like ligand binding domain MatE PF01554.18 CAV27467.1 - 3e-37 127.8 37.2 2.6e-20 72.7 14.1 2.3 2 0 0 2 2 2 2 MatE Polysacc_synt_C PF14667.6 CAV27467.1 - 1.2e-10 41.6 25.7 1.1e-08 35.3 14.5 4.3 3 2 1 4 4 4 2 Polysaccharide biosynthesis C-terminal domain MFS_1 PF07690.16 CAV27469.1 - 8.5e-15 54.5 41.3 2.5e-11 43.1 16.4 1.9 1 1 1 2 2 2 2 Major Facilitator Superfamily VKOR PF07884.14 CAV27470.1 - 0.11 12.6 4.0 3 8.0 1.3 2.1 2 0 0 2 2 2 0 Vitamin K epoxide reductase family EcKinase PF02958.20 CAV27472.1 - 4e-12 46.1 0.3 5.9e-09 35.7 0.4 3.1 1 1 0 2 2 2 2 Ecdysteroid kinase APH PF01636.23 CAV27472.1 - 1.1e-07 32.1 6.7 1.4e-07 31.7 5.7 1.5 1 1 0 1 1 1 1 Phosphotransferase enzyme family DUF1679 PF07914.11 CAV27472.1 - 3.7e-07 29.3 0.2 8.4e-07 28.2 0.1 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF1679) Choline_kinase PF01633.20 CAV27472.1 - 0.12 11.9 0.6 0.65 9.6 0.0 2.2 2 1 0 2 2 2 0 Choline/ethanolamine kinase Acetyltransf_CG PF14542.6 CAV27474.1 - 4.6e-21 74.7 0.0 5.8e-21 74.4 0.0 1.1 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase Acetyltransf_10 PF13673.7 CAV27474.1 - 0.0066 16.4 0.0 0.0088 16.0 0.0 1.3 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 CAV27474.1 - 0.036 14.3 0.0 0.04 14.1 0.0 1.1 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family FlgO PF17680.1 CAV27474.1 - 0.14 11.9 0.0 0.23 11.2 0.0 1.4 1 1 0 1 1 1 0 FlgO protein YcgR_2 PF12945.7 CAV27475.1 - 1.5e-17 63.5 0.0 3.4e-17 62.4 0.0 1.6 1 0 0 1 1 1 1 Flagellar protein YcgR PilZ PF07238.14 CAV27475.1 - 3e-11 43.5 0.0 6.4e-11 42.5 0.0 1.6 2 0 0 2 2 2 1 PilZ domain TUDOR_5 PF18359.1 CAV27475.1 - 0.0019 17.8 0.0 0.54 10.0 0.0 2.5 2 0 0 2 2 2 2 Histone methyltransferase Tudor domain 1 AAA_32 PF13654.6 CAV27477.1 - 3.3e-182 606.9 8.0 3.9e-182 606.6 8.0 1.1 1 0 0 1 1 1 1 AAA domain Lon_C PF05362.13 CAV27477.1 - 9e-10 38.4 0.0 3.9e-09 36.3 0.0 2.1 2 1 0 2 2 2 1 Lon protease (S16) C-terminal proteolytic domain Mg_chelatase PF01078.21 CAV27477.1 - 0.011 15.1 0.0 1.1 8.7 0.0 2.8 3 0 0 3 3 3 0 Magnesium chelatase, subunit ChlI Sigma54_activat PF00158.26 CAV27477.1 - 0.029 14.1 0.0 0.45 10.2 0.0 2.3 2 0 0 2 2 2 0 Sigma-54 interaction domain APP_E2 PF12925.7 CAV27477.1 - 0.081 12.6 2.5 0.16 11.7 0.2 2.2 2 0 0 2 2 2 0 E2 domain of amyloid precursor protein Luciferase_N PF05295.11 CAV27477.1 - 0.1 12.6 1.6 0.27 11.3 0.6 2.2 2 0 0 2 2 2 0 Luciferase/LBP N-terminal domain HAD_2 PF13419.6 CAV27477.1 - 1.5 8.9 5.5 4.8 7.2 0.2 2.8 2 1 1 3 3 3 0 Haloacid dehalogenase-like hydrolase DUF4795 PF16043.5 CAV27477.1 - 1.6 8.3 5.4 0.49 10.0 1.2 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4795) TPR_2 PF07719.17 CAV27478.1 - 0.0031 17.5 0.1 0.076 13.2 0.0 2.7 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.6 CAV27478.1 - 0.0039 17.5 2.5 2.5 8.4 0.1 2.6 2 1 0 2 2 2 2 Tetratricopeptide repeat TPR_14 PF13428.6 CAV27478.1 - 0.022 15.6 0.5 1.3 10.0 0.0 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_4 PF07721.14 CAV27478.1 - 0.098 13.3 0.9 0.86 10.4 0.0 2.6 3 0 0 3 3 3 0 Tetratricopeptide repeat ABC_tran PF00005.27 CAV27480.1 - 6.8e-62 208.0 0.2 3.3e-33 115.1 0.0 2.2 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 CAV27480.1 - 2.8e-13 49.8 1.2 2.8e-07 30.2 0.0 2.7 2 1 0 2 2 2 2 RecF/RecN/SMC N terminal domain oligo_HPY PF08352.12 CAV27480.1 - 4.4e-12 46.3 0.0 8e-06 26.3 0.0 2.6 2 0 0 2 2 2 2 Oligopeptide/dipeptide transporter, C-terminal region AAA_21 PF13304.6 CAV27480.1 - 1.1e-10 41.8 13.1 5.2e-05 23.2 0.8 4.0 2 2 1 4 4 4 3 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 CAV27480.1 - 1.4e-08 34.3 1.0 0.0037 17.0 0.1 2.4 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_22 PF13401.6 CAV27480.1 - 9.7e-07 29.1 5.1 0.021 15.1 0.1 3.8 2 2 0 2 2 2 2 AAA domain AAA_16 PF13191.6 CAV27480.1 - 9.7e-07 29.3 0.2 0.06 13.7 0.2 2.4 2 1 0 2 2 2 2 AAA ATPase domain RsgA_GTPase PF03193.16 CAV27480.1 - 3.5e-06 27.0 1.9 0.06 13.3 0.1 2.8 3 0 0 3 3 3 2 RsgA GTPase Mg_chelatase PF01078.21 CAV27480.1 - 7.9e-06 25.4 0.2 0.14 11.5 0.1 2.9 2 1 0 2 2 2 2 Magnesium chelatase, subunit ChlI MMR_HSR1 PF01926.23 CAV27480.1 - 2.6e-05 24.3 0.0 0.028 14.5 0.0 2.7 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_7 PF12775.7 CAV27480.1 - 8.1e-05 22.2 1.2 0.09 12.3 0.0 3.2 3 0 0 3 3 3 1 P-loop containing dynein motor region APS_kinase PF01583.20 CAV27480.1 - 0.0002 21.3 0.1 0.11 12.4 0.0 2.4 2 0 0 2 2 2 1 Adenylylsulphate kinase AAA_23 PF13476.6 CAV27480.1 - 0.00027 21.5 0.0 0.36 11.3 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_13 PF13166.6 CAV27480.1 - 0.00032 19.5 0.3 0.72 8.4 0.1 3.2 4 0 0 4 4 4 2 AAA domain Sigma54_activat PF00158.26 CAV27480.1 - 0.00036 20.3 0.1 0.38 10.4 0.0 2.6 2 0 0 2 2 2 2 Sigma-54 interaction domain FtsK_SpoIIIE PF01580.18 CAV27480.1 - 0.00068 19.1 1.7 0.22 10.9 0.1 2.3 2 0 0 2 2 2 2 FtsK/SpoIIIE family T2SSE PF00437.20 CAV27480.1 - 0.00099 18.2 0.2 0.43 9.6 0.0 2.3 2 0 0 2 2 2 2 Type II/IV secretion system protein DUF87 PF01935.17 CAV27480.1 - 0.0011 19.1 1.9 1.2 9.2 0.0 2.5 2 0 0 2 2 2 2 Helicase HerA, central domain AAA_33 PF13671.6 CAV27480.1 - 0.0014 18.8 0.0 0.98 9.6 0.0 2.5 2 0 0 2 2 2 1 AAA domain ATP-synt_ab PF00006.25 CAV27480.1 - 0.0026 17.4 0.0 0.93 9.1 0.0 2.4 2 0 0 2 2 2 1 ATP synthase alpha/beta family, nucleotide-binding domain AAA_18 PF13238.6 CAV27480.1 - 0.0029 18.2 0.0 0.91 10.1 0.0 2.9 2 0 0 2 2 2 1 AAA domain AAA_5 PF07728.14 CAV27480.1 - 0.004 17.2 0.9 6.1 6.8 0.1 4.1 4 1 0 4 4 4 0 AAA domain (dynein-related subfamily) NACHT PF05729.12 CAV27480.1 - 0.005 16.8 0.5 2.8 7.8 0.6 2.7 2 1 0 2 2 2 1 NACHT domain RNA_helicase PF00910.22 CAV27480.1 - 0.0051 17.2 0.5 3.4 8.1 0.0 2.9 2 1 0 2 2 2 1 RNA helicase AAA_24 PF13479.6 CAV27480.1 - 0.008 15.9 0.1 3.9 7.1 0.0 2.5 2 0 0 2 2 2 1 AAA domain IstB_IS21 PF01695.17 CAV27480.1 - 0.017 14.9 0.4 9.1 6.0 0.0 2.8 3 0 0 3 3 3 0 IstB-like ATP binding protein DUF3987 PF13148.6 CAV27480.1 - 0.02 14.0 0.1 1.3 7.9 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3987) AAA_10 PF12846.7 CAV27480.1 - 0.02 13.9 0.2 0.2 10.5 0.0 2.3 2 0 0 2 2 2 0 AAA-like domain PRK PF00485.18 CAV27480.1 - 0.023 14.4 0.1 3.5 7.3 0.0 2.3 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family AAA_30 PF13604.6 CAV27480.1 - 0.024 14.4 0.4 3.7 7.2 0.1 2.5 3 0 0 3 3 2 0 AAA domain MobB PF03205.14 CAV27480.1 - 0.03 14.2 0.2 0.64 9.9 0.1 2.5 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B DUF2813 PF11398.8 CAV27480.1 - 0.033 13.4 0.0 0.25 10.5 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2813) Septin PF00735.18 CAV27480.1 - 0.053 12.8 0.2 11 5.2 0.0 2.4 2 0 0 2 2 2 0 Septin NB-ARC PF00931.22 CAV27480.1 - 0.085 12.0 0.8 6.8 5.8 0.3 2.5 2 0 0 2 2 2 0 NB-ARC domain ATP_bind_1 PF03029.17 CAV27480.1 - 0.12 12.2 0.3 2.8 7.7 0.1 2.6 3 0 0 3 3 2 0 Conserved hypothetical ATP binding protein Pox_A32 PF04665.12 CAV27480.1 - 0.12 11.8 0.8 7.6 5.9 0.0 2.7 2 0 0 2 2 2 0 Poxvirus A32 protein ABC_ATPase PF09818.9 CAV27480.1 - 0.14 10.9 6.0 13 4.4 0.0 3.9 3 2 0 3 3 3 0 Predicted ATPase of the ABC class AIG1 PF04548.16 CAV27480.1 - 0.15 11.4 2.8 1.8 7.9 0.0 3.0 3 0 0 3 3 3 0 AIG1 family CbiA PF01656.23 CAV27480.1 - 0.37 10.8 2.0 7.6 6.6 0.1 2.6 2 2 0 2 2 2 0 CobQ/CobB/MinD/ParA nucleotide binding domain Herpes_LAMP2 PF06126.11 CAV27482.1 - 0.0042 15.8 0.2 0.0044 15.7 0.2 1.2 1 0 0 1 1 1 1 Herpesvirus Latent membrane protein 2 RRF PF01765.19 CAV27484.1 - 0.033 14.2 0.0 0.086 12.8 0.0 1.7 1 0 0 1 1 1 0 Ribosome recycling factor Peripla_BP_3 PF13377.6 CAV27492.1 - 2.9e-35 122.1 0.0 9.1e-35 120.4 0.0 1.7 2 0 0 2 2 2 1 Periplasmic binding protein-like domain Peripla_BP_1 PF00532.21 CAV27492.1 - 1.6e-31 109.8 0.0 2.4e-31 109.2 0.0 1.2 1 0 0 1 1 1 1 Periplasmic binding proteins and sugar binding domain of LacI family Peripla_BP_4 PF13407.6 CAV27492.1 - 3.3e-21 76.0 0.0 5.4e-21 75.3 0.0 1.3 2 0 0 2 2 2 1 Periplasmic binding protein domain LacI PF00356.21 CAV27492.1 - 4.3e-17 61.6 0.2 9.8e-17 60.5 0.1 1.7 2 0 0 2 2 1 1 Bacterial regulatory proteins, lacI family HTH_3 PF01381.22 CAV27492.1 - 0.00058 19.9 0.0 0.0031 17.5 0.0 2.2 2 0 0 2 2 2 1 Helix-turn-helix HTH_38 PF13936.6 CAV27492.1 - 0.00088 19.0 0.1 0.0035 17.1 0.0 2.0 2 0 0 2 2 2 1 Helix-turn-helix domain MarR_2 PF12802.7 CAV27492.1 - 0.0067 16.3 0.0 0.16 11.9 0.1 2.4 2 0 0 2 2 2 1 MarR family HTH_IclR PF09339.10 CAV27492.1 - 0.011 15.5 0.1 0.087 12.6 0.0 2.5 3 0 0 3 3 3 0 IclR helix-turn-helix domain HTH_Tnp_ISL3 PF13542.6 CAV27492.1 - 0.024 14.0 0.1 0.048 13.1 0.1 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain of transposase family ISL3 HTH_Crp_2 PF13545.6 CAV27492.1 - 0.025 14.5 0.0 0.31 11.0 0.0 2.5 3 0 0 3 3 2 0 Crp-like helix-turn-helix domain HTH_5 PF01022.20 CAV27492.1 - 0.029 14.2 0.0 0.08 12.8 0.0 1.8 1 0 0 1 1 1 0 Bacterial regulatory protein, arsR family HTH_26 PF13443.6 CAV27492.1 - 0.031 14.7 0.0 0.07 13.6 0.0 1.6 1 0 0 1 1 1 0 Cro/C1-type HTH DNA-binding domain HTH_23 PF13384.6 CAV27492.1 - 0.032 14.0 0.0 0.089 12.6 0.0 1.7 1 0 0 1 1 1 0 Homeodomain-like domain IF2_N PF04760.15 CAV27492.1 - 0.055 13.3 0.1 0.38 10.6 0.0 2.5 3 0 0 3 3 3 0 Translation initiation factor IF-2, N-terminal region HTH_31 PF13560.6 CAV27492.1 - 0.065 13.6 0.0 0.13 12.6 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain YdaS_antitoxin PF15943.5 CAV27492.1 - 0.077 12.9 0.0 0.18 11.7 0.0 1.5 1 0 0 1 1 1 0 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT TnsD PF15978.5 CAV27492.1 - 0.087 11.8 0.1 0.15 11.0 0.1 1.4 1 0 0 1 1 1 0 Tn7-like transposition protein D Topo-VIb_trans PF09239.11 CAV27492.1 - 0.11 12.4 0.0 0.66 9.8 0.0 2.1 2 0 0 2 2 2 0 Topoisomerase VI B subunit, transducer HTH_35 PF13693.6 CAV27492.1 - 0.11 12.6 0.0 0.21 11.6 0.0 1.4 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding DUF608 PF04685.13 CAV27494.1 - 8.7e-62 209.4 0.7 1.7e-61 208.5 0.7 1.4 1 0 0 1 1 1 1 Glycosyl-hydrolase family 116, catalytic region Glyco_hydr_116N PF12215.8 CAV27494.1 - 1.2e-19 71.0 0.1 2.3e-19 70.0 0.1 1.5 1 1 0 1 1 1 1 beta-glucosidase 2, glycosyl-hydrolase family 116 N-term Bac_rhamnosid6H PF17389.2 CAV27494.1 - 0.00077 18.8 0.1 0.0017 17.7 0.1 1.5 1 0 0 1 1 1 1 Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain Trehalase PF01204.18 CAV27494.1 - 0.018 13.9 0.0 0.036 12.9 0.0 1.4 1 0 0 1 1 1 0 Trehalase Glyco_hydro_36 PF17167.4 CAV27494.1 - 0.033 12.9 0.1 0.1 11.2 0.1 1.7 2 0 0 2 2 2 0 Glycosyl hydrolase 36 superfamily, catalytic domain DUF1793 PF08760.11 CAV27494.1 - 0.053 14.0 0.4 17 5.8 0.0 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF1793) Aldose_epim PF01263.20 CAV27496.1 - 5.3e-35 121.2 0.4 6e-35 121.0 0.4 1.0 1 0 0 1 1 1 1 Aldose 1-epimerase Glyco_hydro_36 PF17167.4 CAV27498.1 - 5e-133 443.9 0.7 6.4e-133 443.5 0.7 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase 36 superfamily, catalytic domain Glyco_transf_36 PF06165.11 CAV27498.1 - 4.6e-44 150.7 0.0 7.2e-44 150.1 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 36 GDE_C PF06202.14 CAV27498.1 - 0.0073 15.3 0.0 0.023 13.7 0.0 1.8 2 0 0 2 2 2 1 Amylo-alpha-1,6-glucosidase Glyco_hydro_65C PF03633.15 CAV27498.1 - 0.035 14.0 0.0 0.11 12.4 0.0 1.9 1 0 0 1 1 1 0 Glycosyl hydrolase family 65, C-terminal domain ABC_tran PF00005.27 CAV27499.1 - 1.5e-29 103.2 0.0 2.4e-29 102.6 0.0 1.3 1 0 0 1 1 1 1 ABC transporter OB_MalK PF17912.1 CAV27499.1 - 1e-08 35.9 0.1 5.5e-08 33.5 0.0 2.4 2 0 0 2 2 1 1 MalK OB fold domain AAA_21 PF13304.6 CAV27499.1 - 1e-06 28.8 0.0 0.033 14.0 0.0 2.2 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system Rad17 PF03215.15 CAV27499.1 - 0.00014 21.8 0.0 0.00024 21.1 0.0 1.4 1 0 0 1 1 1 1 Rad17 P-loop domain SMC_N PF02463.19 CAV27499.1 - 0.00044 19.7 0.1 0.0034 16.9 0.1 2.1 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain CysA_C_terminal PF17850.1 CAV27499.1 - 0.00063 20.3 0.1 0.0029 18.1 0.0 2.2 2 0 0 2 2 2 1 CysA C-terminal regulatory domain RsgA_GTPase PF03193.16 CAV27499.1 - 0.00065 19.6 0.0 0.0012 18.8 0.0 1.4 1 0 0 1 1 1 1 RsgA GTPase AAA_23 PF13476.6 CAV27499.1 - 0.0057 17.2 0.0 0.0097 16.4 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 CAV27499.1 - 0.0087 16.3 0.1 0.018 15.3 0.1 1.6 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 CAV27499.1 - 0.011 16.2 0.1 0.011 16.2 0.1 2.0 2 1 0 2 2 2 0 AAA ATPase domain AAA PF00004.29 CAV27499.1 - 0.018 15.5 0.0 0.1 13.0 0.0 2.1 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) TOBE_2 PF08402.10 CAV27499.1 - 0.024 14.8 0.0 0.049 13.8 0.0 1.6 1 0 0 1 1 1 0 TOBE domain AAA_15 PF13175.6 CAV27499.1 - 0.03 14.1 0.0 0.46 10.1 0.0 2.0 2 0 0 2 2 2 0 AAA ATPase domain AAA_18 PF13238.6 CAV27499.1 - 0.031 14.8 0.0 0.07 13.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.6 CAV27499.1 - 0.031 14.5 0.7 0.059 13.6 0.1 1.7 2 0 0 2 2 2 0 AAA domain MIT_C PF16565.5 CAV27499.1 - 0.048 13.6 0.0 0.11 12.5 0.0 1.6 1 0 0 1 1 1 0 Phospholipase D-like domain at C-terminus of MIT AAA_29 PF13555.6 CAV27499.1 - 0.093 12.5 0.0 0.18 11.6 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_33 PF13671.6 CAV27499.1 - 0.15 12.2 0.1 0.34 11.1 0.0 1.6 2 0 0 2 2 2 0 AAA domain Glyco_hydro_1 PF00232.18 CAV27501.1 - 9.2e-153 508.9 1.5 1.2e-152 508.5 1.5 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 1 GHL6 PF14871.6 CAV27501.1 - 0.024 14.8 0.0 0.28 11.3 0.0 2.5 3 0 0 3 3 3 0 Hypothetical glycosyl hydrolase 6 Glyco_hydro_71 PF03659.14 CAV27501.1 - 0.074 11.9 0.0 0.17 10.6 0.0 1.6 2 0 0 2 2 2 0 Glycosyl hydrolase family 71 BPD_transp_1 PF00528.22 CAV27503.1 - 5.4e-20 71.9 13.5 5.4e-20 71.9 13.5 2.2 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component BPD_transp_1 PF00528.22 CAV27505.1 - 4.3e-08 33.1 31.1 3.2e-07 30.3 31.1 2.2 1 1 0 1 1 1 1 Binding-protein-dependent transport system inner membrane component SBP_bac_8 PF13416.6 CAV27507.1 - 1.9e-38 132.9 2.4 2.6e-38 132.5 2.4 1.1 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_1 PF01547.25 CAV27507.1 - 1.6e-29 103.8 7.1 2.4e-29 103.3 7.1 1.1 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein Phage_ABA_S PF18066.1 CAV27507.1 - 0.0011 19.7 0.3 2 9.1 0.0 2.8 2 1 0 2 2 2 2 Phage ABA sandwich domain Peripla_BP_3 PF13377.6 CAV27509.1 - 1.6e-36 126.1 0.0 4.2e-36 124.8 0.0 1.7 2 0 0 2 2 2 1 Periplasmic binding protein-like domain Peripla_BP_1 PF00532.21 CAV27509.1 - 1.6e-33 116.4 0.0 2e-33 116.1 0.0 1.1 1 0 0 1 1 1 1 Periplasmic binding proteins and sugar binding domain of LacI family Peripla_BP_4 PF13407.6 CAV27509.1 - 1.1e-21 77.5 0.0 1.6e-21 77.1 0.0 1.2 1 0 0 1 1 1 1 Periplasmic binding protein domain LacI PF00356.21 CAV27509.1 - 7.7e-18 64.0 0.3 1.4e-17 63.1 0.3 1.5 1 0 0 1 1 1 1 Bacterial regulatory proteins, lacI family HTH_31 PF13560.6 CAV27509.1 - 0.02 15.2 0.0 0.047 14.0 0.0 1.7 1 0 0 1 1 1 0 Helix-turn-helix domain YdaS_antitoxin PF15943.5 CAV27509.1 - 0.023 14.6 0.0 0.05 13.5 0.0 1.6 1 0 0 1 1 1 0 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT HTH_3 PF01381.22 CAV27509.1 - 0.025 14.7 0.0 0.058 13.5 0.0 1.7 1 0 0 1 1 1 0 Helix-turn-helix HTH_Tnp_ISL3 PF13542.6 CAV27509.1 - 0.035 13.5 0.2 0.093 12.2 0.2 1.7 1 0 0 1 1 1 0 Helix-turn-helix domain of transposase family ISL3 LamB PF02264.15 CAV27510.1 - 2.3e-75 254.8 14.2 2.8e-75 254.6 14.2 1.1 1 0 0 1 1 1 1 LamB porin Sugarporin_N PF11471.8 CAV27510.1 - 0.0024 17.8 0.7 0.0048 16.8 0.7 1.4 1 0 0 1 1 1 1 Maltoporin periplasmic N-terminal extension ABC_tran_CTD PF16326.5 CAV27510.1 - 0.05 13.9 0.6 0.12 12.6 0.6 1.5 1 0 0 1 1 1 0 ABC transporter C-terminal domain Peptidase_S9_N PF02897.15 CAV27514.1 - 2.7e-118 395.4 4.8 3.7e-118 394.9 4.8 1.2 1 0 0 1 1 1 1 Prolyl oligopeptidase, N-terminal beta-propeller domain Peptidase_S9 PF00326.21 CAV27514.1 - 1.1e-66 224.4 0.2 1.9e-66 223.6 0.2 1.4 1 0 0 1 1 1 1 Prolyl oligopeptidase family BLM10_N PF16547.5 CAV27514.1 - 0.083 13.2 0.1 0.21 11.9 0.1 1.6 1 0 0 1 1 1 0 Proteasome-substrate-size regulator, N-terminal LysR_substrate PF03466.20 CAV27516.1 - 6.2e-40 136.8 0.0 8.4e-40 136.4 0.0 1.2 1 0 0 1 1 1 1 LysR substrate binding domain HTH_1 PF00126.27 CAV27516.1 - 6.8e-18 64.4 0.1 6.8e-18 64.4 0.1 1.7 2 0 0 2 2 2 1 Bacterial regulatory helix-turn-helix protein, lysR family Lactate_perm PF02652.14 CAV27518.1 - 1.3e-107 360.8 47.6 3.7e-107 359.2 47.6 1.6 1 1 0 1 1 1 1 L-lactate permease FMN_dh PF01070.18 CAV27520.1 - 2.3e-123 411.7 0.0 2.6e-123 411.5 0.0 1.0 1 0 0 1 1 1 1 FMN-dependent dehydrogenase IMPDH PF00478.25 CAV27520.1 - 2.6e-05 23.4 2.3 0.00073 18.6 1.3 2.7 2 1 1 3 3 3 1 IMP dehydrogenase / GMP reductase domain IGPS PF00218.21 CAV27520.1 - 0.0036 16.5 0.0 0.0063 15.7 0.0 1.3 1 0 0 1 1 1 1 Indole-3-glycerol phosphate synthase Glu_synthase PF01645.17 CAV27520.1 - 0.007 15.5 0.5 0.01 15.0 0.5 1.2 1 0 0 1 1 1 1 Conserved region in glutamate synthase ThiG PF05690.14 CAV27520.1 - 0.011 15.1 0.4 0.19 11.0 0.3 2.2 1 1 1 2 2 2 0 Thiazole biosynthesis protein ThiG FAD-oxidase_C PF02913.19 CAV27521.1 - 4.4e-60 203.4 0.9 9.5e-60 202.3 0.0 2.0 2 0 0 2 2 2 1 FAD linked oxidases, C-terminal domain FAD_binding_4 PF01565.23 CAV27521.1 - 1.4e-29 102.6 0.0 2.9e-29 101.6 0.0 1.6 1 0 0 1 1 1 1 FAD binding domain Fer4_8 PF13183.6 CAV27521.1 - 9.2e-11 42.0 1.2 2.2e-10 40.8 1.2 1.6 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_7 PF12838.7 CAV27521.1 - 5.4e-10 39.7 2.5 1.3e-09 38.5 2.5 1.7 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_17 PF13534.6 CAV27521.1 - 3.6e-09 37.0 2.5 8.6e-09 35.8 2.5 1.7 1 0 0 1 1 1 1 4Fe-4S dicluster domain CCG PF02754.16 CAV27521.1 - 5.8e-06 26.4 7.0 0.0016 18.7 0.0 3.5 4 0 0 4 4 3 2 Cysteine-rich domain Fer4_16 PF13484.6 CAV27521.1 - 6.3e-06 27.0 1.7 2e-05 25.4 1.7 2.0 1 0 0 1 1 1 1 4Fe-4S double cluster binding domain Fer4_9 PF13187.6 CAV27521.1 - 2.7e-05 24.3 2.4 6.9e-05 22.9 2.4 1.7 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_10 PF13237.6 CAV27521.1 - 7.6e-05 22.8 3.1 0.00025 21.1 3.2 1.8 1 1 0 1 1 1 1 4Fe-4S dicluster domain Fer4 PF00037.27 CAV27521.1 - 0.00014 21.5 10.4 0.00034 20.3 2.1 2.5 2 0 0 2 2 2 1 4Fe-4S binding domain Fer4_21 PF14697.6 CAV27521.1 - 0.001 19.2 1.9 0.48 10.6 0.4 2.5 2 0 0 2 2 2 2 4Fe-4S dicluster domain Fer4_4 PF12800.7 CAV27521.1 - 0.0076 16.7 2.2 0.0076 16.7 2.2 2.2 2 0 0 2 2 2 1 4Fe-4S binding domain Fer4_2 PF12797.7 CAV27521.1 - 0.019 15.1 3.4 0.019 15.1 3.4 2.3 2 0 0 2 2 2 0 4Fe-4S binding domain Fer4_18 PF13746.6 CAV27521.1 - 0.29 11.4 4.1 13 6.0 0.9 2.6 1 1 1 2 2 2 0 4Fe-4S dicluster domain Fer4_3 PF12798.7 CAV27521.1 - 1.3 10.1 12.4 9.6 7.4 4.7 2.7 2 0 0 2 2 2 0 4Fe-4S binding domain Fer4_20 PF14691.6 CAV27521.1 - 2.6 7.8 4.7 8.4 6.2 0.1 2.5 1 1 1 2 2 2 0 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster Fer4_6 PF12837.7 CAV27521.1 - 3.7 7.8 11.3 0.061 13.4 3.2 2.1 2 0 0 2 2 2 0 4Fe-4S binding domain Fer4_13 PF13370.6 CAV27521.1 - 3.8 8.1 7.1 34 5.1 2.5 2.7 2 0 0 2 2 2 0 4Fe-4S single cluster domain of Ferredoxin I Peptidase_C42 PF05533.12 CAV27524.1 - 0.059 13.4 0.0 0.077 13.0 0.0 1.1 1 0 0 1 1 1 0 Beet yellows virus-type papain-like endopeptidase C42 GyrI-like PF06445.15 CAV27526.1 - 8.2e-29 100.9 0.0 1.1e-28 100.5 0.0 1.2 1 0 0 1 1 1 1 GyrI-like small molecule binding domain HTH_18 PF12833.7 CAV27526.1 - 5.3e-25 87.5 0.6 1.2e-24 86.4 0.6 1.6 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 CAV27526.1 - 1.5e-18 66.4 10.9 1.2e-10 41.2 0.1 3.4 5 0 0 5 5 5 2 Bacterial regulatory helix-turn-helix proteins, AraC family Cass2 PF14526.6 CAV27526.1 - 2.2e-13 50.6 0.0 3.4e-13 50.0 0.0 1.3 1 0 0 1 1 1 1 Integron-associated effector binding protein Aminotran_1_2 PF00155.21 CAV27527.1 - 4.9e-33 114.8 0.0 5.6e-33 114.6 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_MocR PF12897.7 CAV27527.1 - 1.3e-10 40.7 0.0 1.8e-10 40.2 0.0 1.2 1 0 0 1 1 1 1 Alanine-glyoxylate amino-transferase YAcAr PF10686.9 CAV27527.1 - 0.16 11.9 0.0 0.41 10.6 0.0 1.7 1 0 0 1 1 1 0 YspA, cpYpsA-related SLOG family UPF0176_N PF17773.1 CAV27529.1 - 2.5e-28 98.3 0.0 4.6e-28 97.4 0.0 1.4 1 0 0 1 1 1 1 UPF0176 acylphosphatase like domain Rhodanese PF00581.20 CAV27529.1 - 1.5e-09 38.3 0.0 3.9e-09 37.0 0.0 1.8 1 0 0 1 1 1 1 Rhodanese-like domain Rhodanese_C PF12368.8 CAV27529.1 - 0.002 18.4 1.9 0.0047 17.3 1.9 1.6 1 0 0 1 1 1 1 Rhodanase C-terminal BLUF PF04940.12 CAV27529.1 - 0.041 14.0 0.0 0.077 13.1 0.0 1.5 1 0 0 1 1 1 0 Sensors of blue-light using FAD DUF465 PF04325.13 CAV27531.1 - 2.8e-11 43.3 1.3 5.6e-11 42.3 1.3 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF465) Acetyltransf_10 PF13673.7 CAV27533.1 - 1.9e-10 40.7 0.0 2.5e-10 40.4 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 CAV27533.1 - 6.9e-08 32.7 0.0 9.1e-08 32.4 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 CAV27533.1 - 1.7e-07 31.6 0.0 3e-07 30.8 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 CAV27533.1 - 0.0052 16.7 0.0 0.0082 16.1 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein Phosphodiest PF01663.22 CAV27535.1 - 2.6e-10 40.5 0.0 9.7e-10 38.6 0.0 1.9 2 0 0 2 2 2 1 Type I phosphodiesterase / nucleotide pyrophosphatase DUF1840 PF08895.11 CAV27537.1 - 7.4e-33 113.1 0.1 8.3e-33 113.0 0.1 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1840) TFIIE-A_C PF11521.8 CAV27537.1 - 0.036 14.4 0.3 0.049 13.9 0.3 1.2 1 0 0 1 1 1 0 C-terminal general transcription factor TFIIE alpha GGDEF PF00990.21 CAV27539.1 - 1.7e-39 135.2 0.0 2.5e-39 134.6 0.0 1.3 1 0 0 1 1 1 1 Diguanylate cyclase, GGDEF domain Tmemb_9 PF05434.11 CAV27541.1 - 0.24 11.3 2.3 0.39 10.6 0.1 1.9 1 1 1 2 2 2 0 TMEM9 Pirin PF02678.16 CAV27543.1 - 4.1e-34 116.8 2.3 4.8e-33 113.4 0.7 2.3 2 0 0 2 2 2 1 Pirin Pirin_C PF05726.13 CAV27543.1 - 1.9e-27 95.6 0.0 5.1e-27 94.3 0.0 1.7 2 0 0 2 2 2 1 Pirin C-terminal cupin domain Pirin_C_2 PF17954.1 CAV27543.1 - 0.00086 19.4 0.5 0.033 14.4 0.0 2.8 3 0 0 3 3 3 1 Quercetinase C-terminal cupin domain Ppnp PF06865.11 CAV27545.1 - 1.5e-32 111.9 0.2 1.6e-32 111.7 0.2 1.0 1 0 0 1 1 1 1 Pyrimidine/purine nucleoside phosphorylase DUF2850 PF11012.8 CAV27547.1 - 2.6e-30 104.5 0.0 4.7e-30 103.7 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2850) Spore_YpjB PF09577.10 CAV27547.1 - 0.17 11.7 0.1 0.3 10.8 0.1 1.3 1 0 0 1 1 1 0 Sporulation protein YpjB (SpoYpjB) Glyco_hydro_18 PF00704.28 CAV27548.1 - 1.4e-86 291.1 0.5 1.4e-86 291.1 0.5 1.7 2 0 0 2 2 2 1 Glycosyl hydrolases family 18 ChitinaseA_N PF08329.10 CAV27548.1 - 2.6e-55 185.7 1.3 1.5e-54 183.2 0.1 2.4 2 0 0 2 2 2 1 Chitinase A, N-terminal domain CBM_5_12 PF02839.14 CAV27548.1 - 0.0019 18.7 9.2 0.0019 18.7 9.2 2.8 2 0 0 2 2 2 1 Carbohydrate binding domain DoxA PF07680.11 CAV27548.1 - 0.066 13.1 0.1 2 8.3 0.0 2.5 2 0 0 2 2 2 0 TQO small subunit DoxA Pertactin PF03212.14 CAV27548.1 - 0.8 9.7 6.0 0.18 11.8 1.2 2.4 2 0 0 2 2 2 0 Pertactin Hydrolase_4 PF12146.8 CAV27550.1 - 1.6e-10 40.7 0.2 2.6e-10 40.0 0.2 1.4 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 CAV27550.1 - 1.7e-08 35.3 1.9 2.2e-08 35.0 1.9 1.3 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 CAV27550.1 - 8.2e-06 25.6 0.9 1.7e-05 24.6 0.8 1.5 2 0 0 2 2 2 1 alpha/beta hydrolase fold Chlorophyllase2 PF12740.7 CAV27550.1 - 0.0057 15.6 0.3 0.028 13.3 0.3 1.9 1 1 0 1 1 1 1 Chlorophyllase enzyme Ser_hydrolase PF06821.13 CAV27550.1 - 0.017 15.0 0.0 0.21 11.5 0.0 2.4 2 1 0 2 2 2 0 Serine hydrolase TetR_N PF00440.23 CAV27554.1 - 1.4e-11 44.0 0.0 2.2e-11 43.3 0.0 1.3 1 0 0 1 1 1 1 Bacterial regulatory proteins, tetR family MarR_2 PF12802.7 CAV27554.1 - 0.2 11.6 0.0 0.4 10.6 0.0 1.5 1 0 0 1 1 1 0 MarR family Mem_trans PF03547.18 CAV27556.1 - 2.5e-17 62.4 28.4 2.6e-12 45.9 9.2 2.0 1 1 1 2 2 2 2 Membrane transport protein SBF PF01758.16 CAV27556.1 - 5.2e-06 26.3 20.1 0.0001 22.0 5.1 2.4 2 0 0 2 2 2 2 Sodium Bile acid symporter family Acyl_transf_3 PF01757.22 CAV27558.1 - 7.8e-25 87.7 37.8 1e-24 87.3 37.8 1.1 1 0 0 1 1 1 1 Acyltransferase family Cupin_6 PF12852.7 CAV27559.1 - 5.4e-23 81.7 0.1 5.5e-22 78.4 0.1 2.2 1 1 0 1 1 1 1 Cupin HTH_AraC PF00165.23 CAV27559.1 - 1.5e-17 63.2 0.0 1.4e-07 31.4 0.0 2.5 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family HTH_18 PF12833.7 CAV27559.1 - 2.1e-17 63.2 0.0 3.4e-17 62.5 0.0 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain Methyltransf_7 PF03492.15 CAV27559.1 - 0.18 11.0 0.0 0.22 10.7 0.0 1.1 1 0 0 1 1 1 0 SAM dependent carboxyl methyltransferase YHS PF04945.13 CAV27561.1 - 2e-05 24.6 0.2 4.1e-05 23.6 0.2 1.6 1 0 0 1 1 1 1 YHS domain START PF01852.19 CAV27563.1 - 6.1e-08 32.3 0.0 7.7e-08 32.0 0.0 1.1 1 0 0 1 1 1 1 START domain TspO_MBR PF03073.15 CAV27564.1 - 0.082 13.0 0.1 0.17 12.0 0.1 1.4 1 0 0 1 1 1 0 TspO/MBR family MAPEG PF01124.18 CAV27566.1 - 7.9e-25 87.2 7.4 9e-25 87.1 7.4 1.0 1 0 0 1 1 1 1 MAPEG family DUF2754 PF10953.8 CAV27566.1 - 0.072 13.3 4.4 0.16 12.2 0.7 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF2754) Sarcolipin PF05366.11 CAV27566.1 - 1.4 8.7 5.9 8.1 6.2 0.9 2.7 2 0 0 2 2 2 0 Sarcolipin Gate PF07670.14 CAV27568.1 - 7.5e-07 29.4 7.5 7.5e-07 29.4 7.5 2.3 1 1 1 2 2 2 1 Nucleoside recognition Fst_toxin PF13955.6 CAV27568.1 - 0.071 13.0 0.1 0.22 11.5 0.1 1.9 1 0 0 1 1 1 0 Toxin Fst, type I toxin-antitoxin system Gate PF07670.14 CAV27570.1 - 1.2e-10 41.7 0.3 1.2e-10 41.7 0.3 2.0 2 1 0 2 2 2 1 Nucleoside recognition CitMHS PF03600.16 CAV27571.1 - 1e-53 182.5 24.0 1.8e-53 181.7 24.0 1.4 1 0 0 1 1 1 1 Citrate transporter DUF5640 PF18692.1 CAV27573.1 - 0.022 14.8 0.1 0.03 14.4 0.1 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5640) LPAM_1 PF08139.12 CAV27573.1 - 1.2 9.8 3.5 2.5 8.8 3.5 1.5 1 0 0 1 1 1 0 Prokaryotic membrane lipoprotein lipid attachment site DNA_binding_1 PF01035.20 CAV27575.1 - 4.2e-33 113.3 0.1 5.6e-33 112.9 0.1 1.2 1 0 0 1 1 1 1 6-O-methylguanine DNA methyltransferase, DNA binding domain Methyltransf_1N PF02870.15 CAV27575.1 - 5.2e-06 27.2 0.0 8.4e-06 26.5 0.0 1.4 1 0 0 1 1 1 1 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain AlkA_N PF06029.11 CAV27576.1 - 5.9e-34 116.8 0.0 1.2e-33 115.8 0.0 1.6 1 0 0 1 1 1 1 AlkA N-terminal domain Ada_Zn_binding PF02805.16 CAV27576.1 - 1.4e-28 98.7 4.1 2.3e-28 98.0 4.1 1.4 1 0 0 1 1 1 1 Metal binding domain of Ada HTH_18 PF12833.7 CAV27576.1 - 1.5e-18 66.8 0.2 3.8e-18 65.5 0.2 1.7 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 CAV27576.1 - 3.1e-16 59.0 2.0 5.2e-08 32.8 0.1 2.8 3 0 0 3 3 3 2 Bacterial regulatory helix-turn-helix proteins, AraC family HhH-GPD PF00730.25 CAV27576.1 - 9.9e-06 26.0 0.0 4.1e-05 24.0 0.0 2.0 2 1 0 2 2 2 1 HhH-GPD superfamily base excision DNA repair protein HTH_1 PF00126.27 CAV27580.1 - 2.1e-16 59.6 0.1 2.1e-16 59.6 0.1 2.0 2 0 0 2 2 2 1 Bacterial regulatory helix-turn-helix protein, lysR family LysR_substrate PF03466.20 CAV27580.1 - 2.8e-10 39.9 0.0 3.9e-10 39.4 0.0 1.2 1 0 0 1 1 1 1 LysR substrate binding domain DUF413 PF04219.12 CAV27582.1 - 2.8e-35 120.2 0.1 3.4e-35 119.9 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function, DUF LIP1 PF15904.5 CAV27582.1 - 0.14 12.5 0.0 0.2 12.0 0.0 1.2 1 0 0 1 1 1 0 LKB1 serine/threonine kinase interacting protein 1 Glucosamine_iso PF01182.20 CAV27584.1 - 4e-20 72.7 0.0 5.9e-20 72.1 0.0 1.2 1 0 0 1 1 1 1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase ANT PF03374.14 CAV27586.1 - 3.7e-06 27.2 0.0 0.042 14.2 0.0 2.3 2 0 0 2 2 2 2 Phage antirepressor protein KilAC domain HemN_C PF06969.16 CAV27586.1 - 0.0066 16.5 0.2 5.2 7.2 0.0 2.7 3 0 0 3 3 3 2 HemN C-terminal domain HTH_45 PF14947.6 CAV27586.1 - 0.073 13.1 0.0 1.6 8.8 0.0 2.4 2 1 0 2 2 2 0 Winged helix-turn-helix Nitroreductase PF00881.24 CAV27588.1 - 4.5e-19 69.1 0.1 5.9e-19 68.8 0.1 1.2 1 0 0 1 1 1 1 Nitroreductase family TM1586_NiRdase PF14512.6 CAV27588.1 - 0.0021 17.7 0.1 0.0063 16.1 0.1 1.9 2 0 0 2 2 2 1 Putative TM nitroreductase Rubredoxin PF00301.20 CAV27592.1 - 4.4e-18 65.0 7.5 8.1e-18 64.2 7.5 1.5 1 0 0 1 1 1 1 Rubredoxin Flavodoxin_1 PF00258.25 CAV27592.1 - 6e-11 42.7 0.0 1e-10 42.0 0.0 1.4 1 0 0 1 1 1 1 Flavodoxin Lactamase_B PF00753.27 CAV27592.1 - 7.2e-10 39.2 0.1 1.3e-09 38.4 0.1 1.4 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 CAV27592.1 - 5.4e-05 22.8 0.3 0.0002 21.0 0.1 2.1 2 0 0 2 2 2 1 Beta-lactamase superfamily domain Lactamase_B_6 PF16661.5 CAV27592.1 - 0.0037 16.7 0.0 0.0077 15.7 0.0 1.5 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily domain Flavodoxin_5 PF12724.7 CAV27592.1 - 0.012 15.9 0.0 0.021 15.0 0.0 1.4 1 0 0 1 1 1 0 Flavodoxin domain Flavodoxin_3 PF12641.7 CAV27592.1 - 0.094 12.4 0.0 0.17 11.6 0.0 1.4 1 0 0 1 1 1 0 Flavodoxin domain Pyr_redox_2 PF07992.14 CAV27594.1 - 1.6e-54 185.1 2.5 2e-54 184.9 2.5 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Rbx_binding PF18113.1 CAV27594.1 - 4.4e-21 74.4 0.0 1.1e-20 73.2 0.0 1.7 1 0 0 1 1 1 1 Rubredoxin binding C-terminal domain Pyr_redox PF00070.27 CAV27594.1 - 2.4e-14 53.6 2.1 3.1e-11 43.7 0.0 3.0 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 CAV27594.1 - 3e-14 53.0 0.7 4.3e-14 52.5 0.1 1.6 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 CAV27594.1 - 1.2e-09 37.8 0.4 1.1e-07 31.4 0.1 2.3 1 1 1 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) HI0933_like PF03486.14 CAV27594.1 - 1.2e-07 30.8 2.0 0.036 12.8 0.0 3.8 3 1 1 4 4 4 3 HI0933-like protein NAD_binding_7 PF13241.6 CAV27594.1 - 3.6e-05 24.1 0.6 0.0062 17.0 0.1 2.4 2 0 0 2 2 2 1 Putative NAD(P)-binding DAO PF01266.24 CAV27594.1 - 4.8e-05 23.1 12.9 0.0018 17.9 0.3 3.8 3 1 1 4 4 4 2 FAD dependent oxidoreductase AlaDh_PNT_C PF01262.21 CAV27594.1 - 0.00021 20.7 5.6 0.016 14.5 0.4 2.4 2 1 0 2 2 2 2 Alanine dehydrogenase/PNT, C-terminal domain Lycopene_cycl PF05834.12 CAV27594.1 - 0.00055 19.1 2.9 0.3 10.1 0.1 3.4 3 1 0 3 3 3 1 Lycopene cyclase protein NAD_binding_8 PF13450.6 CAV27594.1 - 0.00055 20.1 0.8 0.058 13.6 0.1 2.8 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain GIDA PF01134.22 CAV27594.1 - 0.00067 18.8 0.8 0.11 11.5 0.0 2.5 2 0 0 2 2 2 2 Glucose inhibited division protein A FAD_binding_2 PF00890.24 CAV27594.1 - 0.0017 17.5 3.2 0.4 9.7 0.0 3.0 3 0 0 3 3 3 2 FAD binding domain TOC159_MAD PF11886.8 CAV27594.1 - 0.0033 16.4 0.0 0.15 10.9 0.0 2.3 2 0 0 2 2 2 1 Translocase of chloroplast 159/132, membrane anchor domain 3HCDH_N PF02737.18 CAV27594.1 - 0.01 15.7 0.7 0.024 14.5 0.0 1.9 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain TrkA_N PF02254.18 CAV27594.1 - 0.074 13.3 3.8 0.13 12.5 0.4 3.0 2 2 1 3 3 3 0 TrkA-N domain Amino_oxidase PF01593.24 CAV27594.1 - 0.22 10.8 0.4 2.6 7.3 0.1 2.4 3 0 0 3 3 3 0 Flavin containing amine oxidoreductase NAD_binding_9 PF13454.6 CAV27594.1 - 0.23 11.5 8.5 14 5.7 0.2 4.2 4 1 1 5 5 4 0 FAD-NAD(P)-binding F420_oxidored PF03807.17 CAV27594.1 - 2.6 8.7 4.9 3.2 8.4 1.0 3.0 2 2 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent Glt_symporter PF03616.14 CAV27597.1 - 9.5e-151 501.7 22.5 1.2e-150 501.4 22.5 1.1 1 0 0 1 1 1 1 Sodium/glutamate symporter DUF2810 PF10928.8 CAV27599.1 - 1.2e-32 111.7 0.5 2.1e-32 110.9 0.5 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2810) Paralemmin PF03285.15 CAV27599.1 - 0.0025 17.5 0.6 0.0029 17.2 0.6 1.1 1 0 0 1 1 1 1 Paralemmin HlyD_2 PF12700.7 CAV27599.1 - 0.04 12.6 5.3 0.046 12.4 5.3 1.1 1 0 0 1 1 1 0 HlyD family secretion protein Flagellin_N PF00669.20 CAV27599.1 - 0.044 13.9 0.6 0.078 13.1 0.6 1.3 1 0 0 1 1 1 0 Bacterial flagellin N-terminal helical region DUF2408 PF10303.9 CAV27599.1 - 0.059 13.9 4.4 0.082 13.5 4.4 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF2408) Syntaxin_2 PF14523.6 CAV27599.1 - 0.065 13.6 4.4 0.086 13.2 4.4 1.3 1 1 0 1 1 1 0 Syntaxin-like protein Cob_adeno_trans PF01923.18 CAV27599.1 - 0.071 13.2 0.2 0.078 13.1 0.2 1.3 1 0 0 1 1 1 0 Cobalamin adenosyltransferase FemAB PF02388.16 CAV27599.1 - 0.094 11.6 2.6 0.094 11.6 2.6 1.2 1 0 0 1 1 1 0 FemAB family Matrilin_ccoil PF10393.9 CAV27599.1 - 0.13 12.1 1.8 5.7 6.9 0.2 2.3 2 0 0 2 2 2 0 Trimeric coiled-coil oligomerisation domain of matrilin GPS2_interact PF15784.5 CAV27599.1 - 0.18 12.3 9.4 4.6 7.7 4.5 2.3 1 1 1 2 2 2 0 G-protein pathway suppressor 2-interacting domain DUF1003 PF06210.11 CAV27599.1 - 0.24 11.5 1.1 1.4 9.0 0.6 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1003) Med9 PF07544.13 CAV27599.1 - 0.26 11.4 4.5 1.8 8.7 4.5 2.2 1 1 0 1 1 1 0 RNA polymerase II transcription mediator complex subunit 9 ABC_tran_CTD PF16326.5 CAV27599.1 - 0.32 11.3 3.2 0.3 11.4 1.2 1.9 2 1 1 3 3 3 0 ABC transporter C-terminal domain ZapB PF06005.12 CAV27599.1 - 0.33 11.4 4.2 0.39 11.2 0.4 2.1 2 0 0 2 2 2 0 Cell division protein ZapB TMF_TATA_bd PF12325.8 CAV27599.1 - 0.34 11.1 5.8 1.6 9.0 5.9 1.9 1 1 0 1 1 1 0 TATA element modulatory factor 1 TATA binding XhlA PF10779.9 CAV27599.1 - 1.1 9.5 4.4 3.7 7.8 4.4 1.9 1 1 0 1 1 1 0 Haemolysin XhlA DUF4140 PF13600.6 CAV27599.1 - 2 8.9 5.0 18 5.8 0.4 2.4 1 1 1 2 2 2 0 N-terminal domain of unknown function (DUF4140) DUF919 PF06034.11 CAV27599.1 - 2.5 8.0 7.9 1 9.2 0.1 2.8 3 1 0 3 3 3 0 Nucleopolyhedrovirus protein of unknown function (DUF919) DivIC PF04977.15 CAV27599.1 - 8.6 6.2 9.0 4.7 7.1 2.7 2.5 1 1 2 3 3 3 0 Septum formation initiator Acyl_transf_3 PF01757.22 CAV27600.1 - 1.7e-26 93.1 33.5 3.1e-26 92.3 33.5 1.4 1 1 0 1 1 1 1 Acyltransferase family Sensor_TM1 PF13755.6 CAV27600.1 - 0.079 12.7 2.0 1.6 8.5 0.1 2.7 2 0 0 2 2 2 0 Sensor N-terminal transmembrane domain Wzy_C PF04932.15 CAV27602.1 - 1.6e-17 63.6 2.5 1.6e-17 63.6 2.5 3.2 3 1 0 3 3 3 1 O-Antigen ligase Phage_holin_3_7 PF05449.11 CAV27602.1 - 0.07 13.1 0.7 0.07 13.1 0.7 2.6 2 1 2 4 4 4 0 Putative 3TM holin, Phage_holin_3 O-antigen_lig PF13425.6 CAV27602.1 - 0.15 10.8 19.0 0.033 13.0 11.5 2.9 2 1 1 3 3 3 0 O-antigen ligase like membrane protein DUF4131 PF13567.6 CAV27602.1 - 3.2 7.4 23.1 6.5 6.4 1.3 4.8 3 2 1 4 4 4 0 Domain of unknown function (DUF4131) Tautomerase_2 PF14552.6 CAV27604.1 - 1.3e-23 82.9 0.1 3e-23 81.7 0.1 1.5 2 0 0 2 2 2 1 Tautomerase enzyme Tautomerase_3 PF14832.6 CAV27604.1 - 0.0055 16.9 0.0 0.0064 16.7 0.0 1.2 1 0 0 1 1 1 1 Putative oxalocrotonate tautomerase enzyme Tautomerase PF01361.21 CAV27604.1 - 0.014 15.3 0.0 0.025 14.5 0.0 1.3 1 0 0 1 1 1 0 Tautomerase enzyme CdiI PF07262.11 CAV27604.1 - 0.025 14.3 0.0 0.031 14.1 0.0 1.1 1 0 0 1 1 1 0 CDI immunity protein CHMI PF02962.15 CAV27604.1 - 0.082 13.2 0.0 0.094 13.0 0.0 1.2 1 0 0 1 1 1 0 5-carboxymethyl-2-hydroxymuconate isomerase LON_substr_bdg PF02190.16 CAV27606.1 - 0.00025 21.0 0.0 0.00027 20.9 0.0 1.1 1 0 0 1 1 1 1 ATP-dependent protease La (LON) substrate-binding domain DUF1780 PF08682.10 CAV27606.1 - 0.16 11.6 0.0 0.46 10.1 0.0 1.7 2 0 0 2 2 2 0 Putative endonuclease, protein of unknown function (DUF1780) Sigma70_r2 PF04542.14 CAV27607.1 - 1.9e-13 49.9 0.0 3.6e-13 49.1 0.0 1.5 1 0 0 1 1 1 1 Sigma-70 region 2 Sigma70_r4_2 PF08281.12 CAV27607.1 - 1.3e-11 44.0 0.2 2e-11 43.4 0.2 1.3 1 0 0 1 1 1 1 Sigma-70, region 4 Sigma70_r4 PF04545.16 CAV27607.1 - 5e-11 42.0 0.2 9.8e-11 41.0 0.2 1.5 1 0 0 1 1 1 1 Sigma-70, region 4 Sigma70_ECF PF07638.11 CAV27607.1 - 0.00014 21.8 0.1 0.00054 19.9 0.1 1.9 1 1 0 1 1 1 1 ECF sigma factor GerE PF00196.19 CAV27607.1 - 0.026 14.1 0.0 0.068 12.7 0.0 1.6 1 0 0 1 1 1 0 Bacterial regulatory proteins, luxR family HTH_24 PF13412.6 CAV27607.1 - 0.028 14.0 0.0 0.053 13.1 0.0 1.3 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding Cupin_7 PF12973.7 CAV27609.1 - 2.2e-17 62.7 0.1 4.4e-17 61.8 0.1 1.5 1 0 0 1 1 1 1 ChrR Cupin-like domain Methyltransf_24 PF13578.6 CAV27609.1 - 0.038 15.0 0.5 0.31 12.1 0.5 2.3 1 1 0 1 1 1 0 Methyltransferase domain Pirin PF02678.16 CAV27609.1 - 0.11 12.5 0.1 0.25 11.3 0.1 1.7 2 0 0 2 2 2 0 Pirin DUF1722 PF08349.11 CAV27610.1 - 3e-41 140.4 2.9 5e-41 139.7 2.9 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1722) DUF523 PF04463.12 CAV27610.1 - 2.1e-32 112.0 0.0 4e-32 111.1 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF523) Phage_int_SAM_5 PF13102.6 CAV27610.1 - 0.0055 17.0 0.2 0.011 16.1 0.2 1.5 1 0 0 1 1 1 1 Phage integrase SAM-like domain FAD_binding_7 PF03441.14 CAV27611.1 - 4.4e-82 274.5 2.1 6.9e-82 273.8 2.1 1.3 1 0 0 1 1 1 1 FAD binding domain of DNA photolyase DNA_photolyase PF00875.18 CAV27611.1 - 1.6e-38 132.3 0.1 2.6e-38 131.6 0.1 1.3 1 0 0 1 1 1 1 DNA photolyase SnoaL_2 PF12680.7 CAV27613.1 - 1.1e-12 48.5 0.0 1.3e-12 48.3 0.0 1.1 1 0 0 1 1 1 1 SnoaL-like domain SnoaL PF07366.12 CAV27613.1 - 6.9e-09 35.6 0.0 9.4e-09 35.1 0.0 1.2 1 0 0 1 1 1 1 SnoaL-like polyketide cyclase DUF2358 PF10184.9 CAV27613.1 - 0.00014 22.1 0.3 0.00022 21.5 0.3 1.3 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2358) LEH PF07858.12 CAV27613.1 - 0.048 13.8 0.0 0.11 12.6 0.0 1.7 1 1 0 1 1 1 0 Limonene-1,2-epoxide hydrolase catalytic domain adh_short PF00106.25 CAV27615.1 - 1.2e-36 126.1 0.0 1.7e-36 125.5 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CAV27615.1 - 2.7e-26 92.6 0.0 4.1e-26 92.0 0.0 1.3 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.21 CAV27615.1 - 4.4e-05 23.1 0.0 0.0001 21.9 0.0 1.6 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family F420_oxidored PF03807.17 CAV27615.1 - 0.0021 18.6 0.0 0.0039 17.7 0.0 1.4 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent RmlD_sub_bind PF04321.17 CAV27615.1 - 0.0034 16.5 0.0 0.0046 16.1 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain NAD_binding_10 PF13460.6 CAV27615.1 - 0.0041 17.0 0.0 0.0085 16.0 0.0 1.5 1 0 0 1 1 1 1 NAD(P)H-binding KR PF08659.10 CAV27615.1 - 0.01 15.8 0.0 0.26 11.2 0.0 2.2 2 0 0 2 2 2 1 KR domain NAD_binding_2 PF03446.15 CAV27615.1 - 0.13 12.5 0.0 0.32 11.1 0.0 1.6 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase ApbA PF02558.16 CAV27615.1 - 0.15 11.7 0.0 0.28 10.8 0.0 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA NmrA PF05368.13 CAV27615.1 - 0.19 11.3 0.0 0.27 10.8 0.0 1.2 1 0 0 1 1 1 0 NmrA-like family Amino_oxidase PF01593.24 CAV27617.1 - 6.6e-22 78.4 0.0 1.1e-20 74.4 0.0 2.1 2 0 0 2 2 2 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 CAV27617.1 - 3.7e-16 59.1 0.0 1.1e-15 57.6 0.0 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 CAV27617.1 - 9.4e-07 28.7 0.1 1.8e-06 27.8 0.1 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 CAV27617.1 - 6.8e-05 22.2 0.0 0.011 14.9 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 CAV27617.1 - 0.00013 21.2 0.0 0.00019 20.6 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain HI0933_like PF03486.14 CAV27617.1 - 0.00022 20.1 0.1 0.031 13.0 0.0 2.3 2 0 0 2 2 2 2 HI0933-like protein Pyr_redox PF00070.27 CAV27617.1 - 0.0003 21.3 0.1 0.014 16.0 0.0 2.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FMO-like PF00743.19 CAV27617.1 - 0.00033 19.2 0.2 0.0026 16.2 0.0 2.0 2 0 0 2 2 2 1 Flavin-binding monooxygenase-like NAD_binding_9 PF13454.6 CAV27617.1 - 0.00062 19.8 0.1 0.23 11.4 0.0 2.6 3 0 0 3 3 3 2 FAD-NAD(P)-binding Thi4 PF01946.17 CAV27617.1 - 0.012 14.9 0.0 0.02 14.1 0.0 1.4 1 0 0 1 1 1 0 Thi4 family Pyr_redox_3 PF13738.6 CAV27617.1 - 0.012 14.8 0.0 3.3 6.9 0.0 2.3 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase DUF1365 PF07103.11 CAV27619.1 - 1.1e-70 238.0 1.1 1.3e-70 237.8 1.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1365) CMAS PF02353.20 CAV27621.1 - 3.6e-81 272.4 1.1 4.8e-81 272.1 1.1 1.1 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_25 PF13649.6 CAV27621.1 - 3.2e-11 43.8 0.0 9.3e-11 42.3 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CAV27621.1 - 3.6e-08 33.9 0.0 8.4e-08 32.8 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CAV27621.1 - 1e-07 32.0 0.0 1.9e-07 31.1 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CAV27621.1 - 4.6e-07 30.5 0.0 1.6e-06 28.8 0.0 2.0 2 0 0 2 2 1 1 Methyltransferase domain MTS PF05175.14 CAV27621.1 - 7.1e-06 25.7 0.0 1.5e-05 24.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase small domain ADH_zinc_N PF00107.26 CAV27621.1 - 1e-05 25.5 0.0 0.00046 20.2 0.0 2.4 1 1 1 2 2 2 1 Zinc-binding dehydrogenase Methyltransf_31 PF13847.6 CAV27621.1 - 3.4e-05 23.7 0.0 8.1e-05 22.5 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain DOT1 PF08123.13 CAV27621.1 - 0.001 18.7 0.0 0.0019 17.8 0.0 1.4 1 0 0 1 1 1 1 Histone methylation protein DOT1 PCMT PF01135.19 CAV27621.1 - 0.0011 18.8 0.0 0.0024 17.6 0.0 1.6 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) DUF938 PF06080.12 CAV27621.1 - 0.0012 18.6 0.0 0.0097 15.7 0.0 2.0 1 1 0 1 1 1 1 Protein of unknown function (DUF938) RrnaAD PF00398.20 CAV27621.1 - 0.0015 17.7 0.1 0.0026 16.9 0.1 1.4 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Methyltransf_16 PF10294.9 CAV27621.1 - 0.0068 16.2 0.0 0.014 15.1 0.0 1.5 1 0 0 1 1 1 1 Lysine methyltransferase Mus7 PF09462.10 CAV27621.1 - 0.009 14.9 0.1 0.011 14.6 0.1 1.3 1 0 0 1 1 1 1 Mus7/MMS22 family Methyltransf_2 PF00891.18 CAV27621.1 - 0.013 14.9 0.0 0.023 14.0 0.0 1.4 1 0 0 1 1 1 0 O-methyltransferase domain Methyltransf_3 PF01596.17 CAV27621.1 - 0.033 13.3 0.1 0.064 12.4 0.1 1.4 1 0 0 1 1 1 0 O-methyltransferase CmcI PF04989.12 CAV27621.1 - 0.041 13.6 0.0 0.078 12.7 0.0 1.4 1 0 0 1 1 1 0 Cephalosporin hydroxylase Methyltransf_32 PF13679.6 CAV27621.1 - 0.12 12.3 0.1 0.3 11.0 0.1 1.7 1 0 0 1 1 1 0 Methyltransferase domain DUF2878 PF11086.8 CAV27622.1 - 7.3e-37 126.9 24.4 8.4e-37 126.8 24.4 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2878) Chalcone_3 PF16036.5 CAV27624.1 - 6.7e-12 45.8 0.0 8.8e-12 45.4 0.0 1.2 1 0 0 1 1 1 1 Chalcone isomerase-like DUF3833 PF12915.7 CAV27626.1 - 4.9e-65 218.1 0.6 5.7e-65 217.9 0.6 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3833) PYC_OADA PF02436.18 CAV27630.1 - 0.03 14.1 0.9 0.033 13.9 0.9 1.1 1 0 0 1 1 1 0 Conserved carboxylase domain adh_short PF00106.25 CAV27632.1 - 4.5e-27 94.8 0.0 6.4e-27 94.3 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CAV27632.1 - 4.7e-16 59.1 0.2 6e-16 58.7 0.2 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CAV27632.1 - 6.6e-11 42.4 0.1 9e-11 42.0 0.1 1.2 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 CAV27632.1 - 1.9e-05 24.0 0.2 0.00069 18.8 0.0 2.0 2 0 0 2 2 2 1 Polysaccharide biosynthesis protein Epimerase PF01370.21 CAV27632.1 - 0.00037 20.0 0.0 0.0006 19.4 0.0 1.4 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.17 CAV27632.1 - 0.0091 15.1 0.0 0.03 13.4 0.0 1.8 1 1 0 1 1 1 1 RmlD substrate binding domain Sacchrp_dh_NADP PF03435.18 CAV27632.1 - 0.012 15.9 0.0 0.048 13.9 0.0 2.0 3 0 0 3 3 3 0 Saccharopine dehydrogenase NADP binding domain F420_oxidored PF03807.17 CAV27632.1 - 0.04 14.5 0.0 0.11 13.0 0.0 1.8 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent MTH865 PF07747.11 CAV27632.1 - 0.16 11.7 0.1 16 5.4 0.0 2.7 3 0 0 3 3 3 0 MTH865-like family RRM_1 PF00076.22 CAV27633.1 - 4.3e-22 77.7 0.0 4.8e-22 77.6 0.0 1.0 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 CAV27633.1 - 0.0027 17.3 0.0 0.0033 17.0 0.0 1.1 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 CAV27633.1 - 0.065 13.3 0.0 0.079 13.0 0.0 1.1 1 0 0 1 1 1 0 RNA binding motif RRF_GI PF12614.8 CAV27635.1 - 1.1e-20 74.0 1.9 9.1e-20 71.1 1.9 1.9 1 1 0 1 1 1 1 Ribosome recycling factor L27_1 PF09058.10 CAV27635.1 - 0.13 12.2 0.0 0.34 10.9 0.0 1.6 1 1 1 2 2 2 0 L27_1 Aminotran_1_2 PF00155.21 CAV27639.1 - 8.3e-40 137.1 0.0 1e-39 136.8 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.20 CAV27639.1 - 0.00037 19.1 0.1 0.001 17.7 0.0 1.6 1 1 0 2 2 2 1 Cys/Met metabolism PLP-dependent enzyme Beta_elim_lyase PF01212.21 CAV27639.1 - 0.0009 18.6 0.0 0.0014 18.0 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase Aminotran_5 PF00266.19 CAV27639.1 - 0.0013 17.8 0.0 0.002 17.1 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class-V OsmC PF02566.19 CAV27640.1 - 6e-17 62.0 0.1 7.8e-17 61.6 0.1 1.1 1 0 0 1 1 1 1 OsmC-like protein GFA PF04828.14 CAV27642.1 - 1e-09 38.6 0.4 1e-09 38.6 0.4 1.6 2 0 0 2 2 2 1 Glutathione-dependent formaldehyde-activating enzyme zf-CCHC_4 PF14392.6 CAV27642.1 - 1.1 9.0 8.2 0.4 10.4 2.1 2.3 2 0 0 2 2 2 0 Zinc knuckle PTS_EIIC PF02378.18 CAV27646.1 - 3.9e-75 252.9 32.6 5.9e-75 252.3 32.6 1.3 1 0 0 1 1 1 1 Phosphotransferase system, EIIC PTS_EIIB PF00367.20 CAV27646.1 - 9.4e-13 47.4 0.1 1.9e-12 46.5 0.1 1.5 1 0 0 1 1 1 1 phosphotransferase system, EIIB DUF1427 PF07235.11 CAV27646.1 - 0.48 10.4 6.1 2 8.4 0.5 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1427) SpoV PF08183.11 CAV27646.1 - 0.58 10.2 3.1 0.47 10.5 0.1 2.4 2 0 0 2 2 2 0 Stage V sporulation protein family 4HB_MCP_1 PF12729.7 CAV27648.1 - 0.61 9.6 3.3 18 4.8 2.5 2.3 2 0 0 2 2 2 0 Four helix bundle sensory module for signal transduction CitMHS PF03600.16 CAV27648.1 - 9.6 5.3 11.0 12 5.0 11.0 1.3 1 1 0 1 1 1 0 Citrate transporter DUF1891 PF09004.10 CAV27650.1 - 0.089 12.4 0.4 0.29 10.8 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF1891) HATPase_c PF02518.26 CAV27653.1 - 1.7e-17 63.9 0.0 3.7e-17 62.8 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 CAV27653.1 - 1e-07 31.9 0.5 2.5e-07 30.6 0.5 1.7 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain HAMP PF00672.25 CAV27653.1 - 0.00021 21.6 0.1 0.0013 19.0 0.0 2.3 2 0 0 2 2 2 1 HAMP domain HATPase_c_3 PF13589.6 CAV27653.1 - 0.00086 19.1 0.0 0.0024 17.7 0.0 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase PRD PF00874.20 CAV27653.1 - 0.025 14.9 0.2 0.4 11.0 0.0 2.8 2 1 0 2 2 2 0 PRD domain Trans_reg_C PF00486.28 CAV27655.1 - 5.6e-26 90.4 0.0 1.1e-25 89.5 0.0 1.5 1 0 0 1 1 1 1 Transcriptional regulatory protein, C terminal Response_reg PF00072.24 CAV27655.1 - 2.6e-25 88.8 0.2 4.3e-25 88.1 0.2 1.4 1 0 0 1 1 1 1 Response regulator receiver domain LysR_substrate PF03466.20 CAV27656.1 - 4.8e-38 130.6 0.0 7.7e-38 130.0 0.0 1.3 1 0 0 1 1 1 1 LysR substrate binding domain HTH_1 PF00126.27 CAV27656.1 - 6.9e-16 58.0 0.2 1.2e-15 57.2 0.2 1.4 1 0 0 1 1 1 1 Bacterial regulatory helix-turn-helix protein, lysR family HTH_30 PF13556.6 CAV27656.1 - 0.00055 19.7 0.1 0.0016 18.2 0.1 1.7 2 0 0 2 2 2 1 PucR C-terminal helix-turn-helix domain HTH_28 PF13518.6 CAV27656.1 - 0.098 12.8 0.1 0.26 11.4 0.1 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_24 PF13412.6 CAV27656.1 - 0.1 12.2 0.0 0.24 11.0 0.0 1.6 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding HTH_AsnC-type PF13404.6 CAV27656.1 - 0.13 12.1 0.2 0.23 11.3 0.2 1.4 1 0 0 1 1 1 0 AsnC-type helix-turn-helix domain adh_short_C2 PF13561.6 CAV27657.1 - 5.6e-31 107.9 3.3 6.3e-30 104.5 1.5 1.9 1 1 1 2 2 2 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CAV27657.1 - 4.5e-17 62.2 3.7 8.4e-13 48.2 0.7 2.1 1 1 1 2 2 2 2 short chain dehydrogenase THF_DHG_CYH_C PF02882.19 CAV27657.1 - 0.0018 17.6 0.2 0.0038 16.6 0.2 1.7 1 1 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain RmlD_sub_bind PF04321.17 CAV27657.1 - 0.0031 16.6 0.0 0.0052 15.9 0.0 1.3 1 0 0 1 1 1 1 RmlD substrate binding domain Epimerase PF01370.21 CAV27657.1 - 0.011 15.3 0.1 0.018 14.5 0.1 1.4 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family DUF5035 PF16438.5 CAV27657.1 - 0.018 14.9 0.0 0.16 11.9 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF5035) KR PF08659.10 CAV27657.1 - 0.027 14.4 1.3 0.68 9.8 0.1 2.4 1 1 2 3 3 3 0 KR domain Glyco_tran_WecB PF03808.13 CAV27657.1 - 0.15 12.0 0.0 0.31 11.0 0.0 1.6 2 0 0 2 2 2 0 Glycosyl transferase WecB/TagA/CpsF family MFS_1 PF07690.16 CAV27658.1 - 8.5e-35 120.3 50.0 4.3e-25 88.4 30.9 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_4 PF06779.14 CAV27658.1 - 6.7e-05 22.4 40.4 8.1e-05 22.1 40.4 1.1 1 0 0 1 1 1 1 Uncharacterised MFS-type transporter YbfB Oxidored_FMN PF00724.20 CAV27659.1 - 3.6e-92 309.3 0.0 4.1e-92 309.1 0.0 1.0 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family AP_endonuc_2 PF01261.24 CAV27659.1 - 0.0075 15.7 0.1 4 6.8 0.0 2.2 1 1 1 2 2 2 2 Xylose isomerase-like TIM barrel Bac_DNA_binding PF00216.21 CAV27659.1 - 0.06 13.6 0.1 1 9.6 0.0 2.4 1 1 1 2 2 2 0 Bacterial DNA-binding protein RsmJ PF04378.13 CAV27661.1 - 2.1e-43 148.3 0.0 2.5e-43 148.1 0.0 1.1 1 0 0 1 1 1 1 Ribosomal RNA large subunit methyltransferase D, RlmJ Cons_hypoth95 PF03602.15 CAV27661.1 - 9.8e-08 31.8 0.0 1.1e-06 28.4 0.0 2.0 2 0 0 2 2 2 1 Conserved hypothetical protein 95 SecD_SecF PF02355.16 CAV27663.1 - 1.2e-55 187.8 7.4 1.2e-55 187.8 7.4 1.9 2 0 0 2 2 2 1 Protein export membrane protein Sec_GG PF07549.14 CAV27663.1 - 4.3e-09 35.6 0.2 1.1e-08 34.3 0.2 1.7 1 0 0 1 1 1 1 SecD/SecF GG Motif SecD-TM1 PF13721.6 CAV27665.1 - 1.4e-24 86.5 2.3 1.4e-24 86.5 2.3 3.6 4 0 0 4 4 4 1 SecD export protein N-terminal TM region SecD_SecF PF02355.16 CAV27665.1 - 8e-19 67.8 5.3 1e-18 67.4 3.8 1.9 2 0 0 2 2 2 1 Protein export membrane protein MMPL PF03176.15 CAV27665.1 - 4.3e-06 25.9 5.2 4.3e-06 25.9 5.2 2.8 2 1 1 3 3 3 1 MMPL family Sec_GG PF07549.14 CAV27665.1 - 6.5e-05 22.3 0.4 0.00015 21.1 0.4 1.6 1 0 0 1 1 1 1 SecD/SecF GG Motif Rhomboid_N PF12122.8 CAV27665.1 - 0.11 12.7 0.4 0.27 11.4 0.4 1.6 1 0 0 1 1 1 0 Cytoplasmic N-terminal domain of rhomboid serine protease ACR_tran PF00873.19 CAV27665.1 - 0.68 7.5 7.2 0.06 11.0 2.0 1.8 2 0 0 2 2 2 0 AcrB/AcrD/AcrF family Peptidase_M16 PF00675.20 CAV27668.1 - 1.8e-29 102.6 0.4 2.7e-27 95.6 0.1 2.6 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.21 CAV27668.1 - 1.8e-28 99.8 0.3 7.4e-15 55.4 0.0 3.1 3 0 0 3 3 3 2 Peptidase M16 inactive domain T3SS_needle_reg PF09025.10 CAV27668.1 - 0.021 14.8 0.1 0.051 13.5 0.1 1.7 1 0 0 1 1 1 0 YopR, type III needle-polymerisation regulator HOASN PF14515.6 CAV27668.1 - 0.031 14.7 0.0 0.17 12.3 0.0 2.3 1 0 0 1 1 1 0 Haem-oxygenase-associated N-terminal helices NusB PF01029.18 CAV27668.1 - 0.045 14.0 1.4 0.16 12.2 1.4 1.9 1 0 0 1 1 1 0 NusB family Syntaxin_2 PF14523.6 CAV27668.1 - 0.22 11.9 1.1 5.4 7.4 0.2 2.8 2 0 0 2 2 2 0 Syntaxin-like protein Uteroglobin PF01099.17 CAV27668.1 - 0.79 10.1 2.3 12 6.3 0.1 3.2 4 0 0 4 4 4 0 Uteroglobin family Peptidase_M16 PF00675.20 CAV27670.1 - 2.2e-29 102.3 0.3 4.1e-27 95.0 0.1 2.9 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.21 CAV27670.1 - 2.6e-28 99.3 2.1 4.3e-13 49.7 0.1 2.5 2 0 0 2 2 2 2 Peptidase M16 inactive domain HOASN PF14515.6 CAV27670.1 - 0.00072 19.9 0.7 0.71 10.3 0.0 3.2 3 0 0 3 3 3 2 Haem-oxygenase-associated N-terminal helices Relaxase PF03432.14 CAV27670.1 - 0.059 13.0 0.2 0.21 11.2 0.0 2.0 2 0 0 2 2 2 0 Relaxase/Mobilisation nuclease domain DUF3932 PF13068.6 CAV27670.1 - 0.088 13.1 0.1 0.89 9.9 0.0 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF3932) PilJ PF13675.6 CAV27670.1 - 0.19 11.7 4.6 0.53 10.3 0.4 3.4 3 0 0 3 3 3 0 Type IV pili methyl-accepting chemotaxis transducer N-term Response_reg PF00072.24 CAV27671.1 - 8.3e-25 87.1 0.1 1.7e-24 86.1 0.1 1.5 1 0 0 1 1 1 1 Response regulator receiver domain LytTR PF04397.15 CAV27671.1 - 4.9e-21 74.8 0.0 1.1e-20 73.7 0.0 1.6 1 0 0 1 1 1 1 LytTr DNA-binding domain His_kinase PF06580.13 CAV27673.1 - 3.2e-24 85.0 1.9 6.3e-24 84.1 1.9 1.5 1 0 0 1 1 1 1 Histidine kinase HATPase_c PF02518.26 CAV27673.1 - 1.1e-07 32.3 0.2 4e-07 30.5 0.2 1.9 1 1 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_2 PF13581.6 CAV27673.1 - 0.0045 17.0 0.0 0.0081 16.1 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-like ATPase domain Chordopox_E11 PF06138.12 CAV27673.1 - 0.044 14.1 0.1 0.11 12.8 0.1 1.6 1 0 0 1 1 1 0 Chordopoxvirus E11 protein LolA_like PF17131.4 CAV27677.1 - 7.2e-38 130.1 0.1 1e-37 129.7 0.1 1.2 1 0 0 1 1 1 1 Outer membrane lipoprotein-sorting protein MacB_PCD PF12704.7 CAV27678.1 - 3.5e-16 60.2 12.0 4.2e-16 59.9 1.1 2.4 2 1 0 2 2 2 2 MacB-like periplasmic core domain FtsX PF02687.21 CAV27678.1 - 7.8e-08 32.7 0.7 7.8e-08 32.7 0.7 2.8 3 0 0 3 3 3 1 FtsX-like permease family ABC2_membrane_3 PF12698.7 CAV27678.1 - 0.007 15.5 0.7 0.007 15.5 0.7 1.7 2 0 0 2 2 2 1 ABC-2 family transporter protein CytB6-F_Fe-S PF08802.10 CAV27678.1 - 0.028 14.5 0.2 5.3 7.1 0.8 3.0 2 0 0 2 2 2 0 Cytochrome B6-F complex Fe-S subunit Alfin PF12165.8 CAV27678.1 - 0.064 12.9 0.0 0.13 12.0 0.0 1.4 1 0 0 1 1 1 0 Alfin ABC_tran PF00005.27 CAV27680.1 - 9.1e-34 116.9 0.0 1.2e-33 116.5 0.0 1.2 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 CAV27680.1 - 4.2e-09 36.6 0.0 0.0026 17.6 0.0 2.1 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 CAV27680.1 - 2.4e-08 33.7 0.1 5e-06 26.1 0.1 2.1 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain RsgA_GTPase PF03193.16 CAV27680.1 - 0.00012 22.0 0.0 0.00027 20.9 0.0 1.5 1 0 0 1 1 1 1 RsgA GTPase AAA_29 PF13555.6 CAV27680.1 - 0.00014 21.6 0.0 0.00025 20.7 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_25 PF13481.6 CAV27680.1 - 0.00073 19.2 0.7 0.0022 17.6 0.0 1.9 2 1 0 2 2 2 1 AAA domain AAA_22 PF13401.6 CAV27680.1 - 0.0013 19.0 0.3 0.0046 17.2 0.3 2.0 1 1 0 1 1 1 1 AAA domain AAA_15 PF13175.6 CAV27680.1 - 0.0016 18.2 0.0 0.54 9.9 0.0 2.1 2 0 0 2 2 2 2 AAA ATPase domain AAA_16 PF13191.6 CAV27680.1 - 0.0019 18.6 0.1 0.0029 18.0 0.1 1.5 1 1 0 1 1 1 1 AAA ATPase domain IstB_IS21 PF01695.17 CAV27680.1 - 0.0032 17.2 0.1 0.018 14.8 0.0 2.0 2 0 0 2 2 2 1 IstB-like ATP binding protein AAA_33 PF13671.6 CAV27680.1 - 0.0058 16.8 0.3 0.014 15.6 0.3 1.9 1 1 0 1 1 1 1 AAA domain AAA_23 PF13476.6 CAV27680.1 - 0.012 16.1 0.1 0.023 15.2 0.1 1.4 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 CAV27680.1 - 0.016 15.7 0.1 0.028 15.0 0.1 1.8 1 1 0 1 1 1 0 AAA domain NACHT PF05729.12 CAV27680.1 - 0.017 15.1 0.3 1.1 9.1 0.1 2.1 2 0 0 2 2 2 0 NACHT domain MMR_HSR1 PF01926.23 CAV27680.1 - 0.025 14.6 0.0 0.047 13.8 0.0 1.8 1 1 0 1 1 1 0 50S ribosome-binding GTPase T2SSE PF00437.20 CAV27680.1 - 0.037 13.1 0.0 0.066 12.3 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein Rad17 PF03215.15 CAV27680.1 - 0.038 13.9 0.0 0.049 13.6 0.0 1.3 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_10 PF12846.7 CAV27680.1 - 0.062 12.2 0.0 0.1 11.5 0.0 1.3 1 0 0 1 1 1 0 AAA-like domain AAA_7 PF12775.7 CAV27680.1 - 0.11 12.0 0.1 0.32 10.5 0.0 1.7 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_13 PF13166.6 CAV27680.1 - 0.22 10.1 0.0 0.69 8.5 0.0 1.7 2 0 0 2 2 2 0 AAA domain HTH_1 PF00126.27 CAV27684.1 - 4.5e-14 52.1 0.0 7.6e-14 51.4 0.0 1.3 1 0 0 1 1 1 1 Bacterial regulatory helix-turn-helix protein, lysR family LysR_substrate PF03466.20 CAV27684.1 - 2.7e-08 33.4 0.0 4e-08 32.9 0.0 1.4 1 1 0 1 1 1 1 LysR substrate binding domain HTH_Mga PF08280.11 CAV27684.1 - 0.011 15.7 0.9 3.8 7.6 0.0 3.6 4 0 0 4 4 4 0 M protein trans-acting positive regulator (MGA) HTH domain DUF4522 PF15022.6 CAV27684.1 - 0.069 13.4 0.0 0.15 12.3 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4522) PQQ_3 PF13570.6 CAV27686.1 - 6.9e-24 83.7 6.9 0.095 13.2 0.0 7.9 7 0 0 7 7 7 6 PQQ-like domain DUF4012 PF13196.6 CAV27686.1 - 4.8e-13 49.8 7.0 2.6 8.5 0.0 6.7 6 0 0 6 6 6 6 Protein of unknown function (DUF4012) SLS PF14611.6 CAV27686.1 - 3.6e-10 40.1 0.4 12 5.6 0.0 6.3 6 0 0 6 6 6 5 Mitochondrial inner-membrane-bound regulator PQQ_2 PF13360.6 CAV27686.1 - 3.5e-06 26.8 6.1 4 7.0 0.1 6.1 1 1 5 6 6 6 4 PQQ-like domain PLD_C PF12357.8 CAV27686.1 - 6.6e-06 26.0 0.1 1e+02 2.9 0.0 6.6 6 0 0 6 6 6 0 Phospholipase D C terminal LLC1 PF14945.6 CAV27686.1 - 0.051 14.1 0.0 6e+02 1.0 0.0 5.1 1 1 5 6 6 6 0 Normal lung function maintenance, Low in Lung Cancer 1 protein IMP_cyclohyd PF07826.11 CAV27686.1 - 0.082 12.5 6.1 2.1e+02 1.4 0.0 5.7 6 0 0 6 6 6 0 IMP cyclohydrolase-like protein Imm-NTF2-2 PF15631.6 CAV27686.1 - 0.14 12.5 0.1 2.3 8.6 0.1 3.2 1 0 0 1 1 1 0 NTF2 fold immunity protein NHL PF01436.21 CAV27686.1 - 1.8 8.7 17.5 1.1e+02 3.1 0.0 6.9 7 0 0 7 7 7 0 NHL repeat Big_1 PF02369.16 CAV27686.1 - 2.1 8.4 6.5 39 4.4 0.0 5.7 7 0 0 7 7 7 0 Bacterial Ig-like domain (group 1) CMD PF02627.20 CAV27691.1 - 1.1e-15 57.4 0.0 1.9e-15 56.6 0.0 1.4 1 0 0 1 1 1 1 Carboxymuconolactone decarboxylase family LysR_substrate PF03466.20 CAV27692.1 - 1.3e-40 139.1 0.0 1.6e-40 138.7 0.0 1.2 1 0 0 1 1 1 1 LysR substrate binding domain HTH_1 PF00126.27 CAV27692.1 - 3.8e-17 62.0 0.0 6.1e-17 61.3 0.0 1.4 1 0 0 1 1 1 1 Bacterial regulatory helix-turn-helix protein, lysR family MCPsignal PF00015.21 CAV27694.1 - 1.2e-39 135.8 21.7 1.2e-39 135.8 21.7 3.4 1 1 2 4 4 4 1 Methyl-accepting chemotaxis protein (MCP) signalling domain 4HB_MCP_1 PF12729.7 CAV27694.1 - 3.2e-07 30.1 0.4 3.2e-07 30.1 0.4 4.8 2 2 0 4 4 4 1 Four helix bundle sensory module for signal transduction cpYpsA PF12694.7 CAV27694.1 - 0.078 12.8 3.9 0.031 14.1 1.2 1.7 2 0 0 2 2 2 0 Circularly permutated YpsA SLOG family DUF3479 PF11965.8 CAV27694.1 - 0.86 9.7 8.0 0.48 10.5 5.5 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF3479) DUF948 PF06103.11 CAV27694.1 - 1.4 9.2 34.7 44 4.4 6.4 6.0 4 2 1 5 5 5 0 Bacterial protein of unknown function (DUF948) YtxH PF12732.7 CAV27694.1 - 2.4 8.8 11.9 26 5.4 2.8 4.2 2 2 0 2 2 2 0 YtxH-like protein NAD_binding_2 PF03446.15 CAV27696.1 - 9e-48 162.4 2.7 1.8e-47 161.4 2.7 1.5 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.6 CAV27696.1 - 1e-31 109.7 0.7 1.8e-31 108.9 0.2 1.7 2 0 0 2 2 2 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase Shikimate_DH PF01488.20 CAV27696.1 - 4.5e-10 39.7 0.0 7.4e-10 39.0 0.0 1.3 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase F420_oxidored PF03807.17 CAV27696.1 - 5.7e-10 39.6 0.0 1.1e-09 38.8 0.0 1.5 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent 2-Hacid_dh_C PF02826.19 CAV27696.1 - 2.3e-09 36.8 0.1 4.3e-09 36.0 0.1 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain IlvN PF07991.12 CAV27696.1 - 0.00015 21.4 0.1 0.00024 20.7 0.1 1.4 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain 3HCDH_N PF02737.18 CAV27696.1 - 0.00022 21.2 2.0 0.0016 18.3 0.2 2.3 1 1 1 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain UDPG_MGDP_dh_N PF03721.14 CAV27696.1 - 0.0029 17.2 0.8 0.087 12.4 0.1 2.2 1 1 1 2 2 2 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain ApbA PF02558.16 CAV27696.1 - 0.014 15.1 0.3 0.063 12.9 0.2 2.2 2 1 0 2 2 2 0 Ketopantoate reductase PanE/ApbA AlaDh_PNT_C PF01262.21 CAV27696.1 - 0.014 14.7 0.8 0.024 13.9 0.8 1.4 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Nuc_deoxyri_tr2 PF15891.5 CAV27696.1 - 0.015 15.6 0.0 0.024 14.9 0.0 1.3 1 0 0 1 1 1 0 Nucleoside 2-deoxyribosyltransferase like PDH PF02153.17 CAV27696.1 - 0.03 13.3 0.2 0.04 12.9 0.2 1.1 1 0 0 1 1 1 0 Prephenate dehydrogenase NAD_binding_10 PF13460.6 CAV27696.1 - 0.038 13.9 0.7 0.074 12.9 0.7 1.5 1 0 0 1 1 1 0 NAD(P)H-binding GFO_IDH_MocA PF01408.22 CAV27696.1 - 0.11 13.4 0.2 0.18 12.7 0.2 1.4 1 0 0 1 1 1 0 Oxidoreductase family, NAD-binding Rossmann fold UDPG_MGDP_dh_C PF03720.15 CAV27696.1 - 0.11 12.9 0.1 0.21 12.0 0.1 1.4 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain LysR_substrate PF03466.20 CAV27698.1 - 4.9e-28 97.9 0.0 7.4e-28 97.4 0.0 1.3 1 0 0 1 1 1 1 LysR substrate binding domain HTH_1 PF00126.27 CAV27698.1 - 3.5e-13 49.3 0.0 2.8e-12 46.4 0.1 2.2 2 0 0 2 2 2 1 Bacterial regulatory helix-turn-helix protein, lysR family DUF2798 PF11391.8 CAV27700.1 - 4.9e-19 68.1 5.8 6.4e-19 67.7 5.8 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2798) Transcrip_reg PF01709.20 CAV27702.1 - 2.5e-69 233.4 0.0 2.8e-69 233.2 0.0 1.0 1 0 0 1 1 1 1 Transcriptional regulator DUF3283 PF11686.8 CAV27704.1 - 4.6e-35 119.3 0.3 5.5e-35 119.0 0.3 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3283) DNA_pol3_theta PF06440.11 CAV27704.1 - 0.008 15.8 0.2 0.027 14.1 0.0 1.9 2 1 0 2 2 2 1 DNA polymerase III, theta subunit HEPN_Apea PF18739.1 CAV27706.1 - 7.6e-06 26.3 1.9 7.6e-06 26.3 1.9 2.5 2 2 0 2 2 2 1 Apea-like HEPN DUF4172 PF13776.6 CAV27708.1 - 4.1e-30 104.0 0.8 9.1e-30 102.8 0.8 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4172) Fic PF02661.18 CAV27708.1 - 9.1e-16 58.5 0.0 2e-14 54.2 0.0 2.2 2 0 0 2 2 2 1 Fic/DOC family Pterin_4a PF01329.19 CAV27710.1 - 1e-29 102.5 0.2 1.3e-29 102.2 0.2 1.1 1 0 0 1 1 1 1 Pterin 4 alpha carbinolamine dehydratase Biopterin_H PF00351.21 CAV27712.1 - 7.1e-44 150.2 0.0 8.8e-44 149.9 0.0 1.0 1 0 0 1 1 1 1 Biopterin-dependent aromatic amino acid hydroxylase AMP-binding PF00501.28 CAV27713.1 - 1.4e-43 149.1 0.0 1.8e-43 148.8 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 CAV27713.1 - 8e-05 23.5 0.0 0.00019 22.4 0.0 1.7 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain ACAS_N PF16177.5 CAV27713.1 - 0.00013 21.8 4.1 0.00013 21.8 4.1 3.0 2 1 0 2 2 2 1 Acetyl-coenzyme A synthetase N-terminus DUF2001 PF09393.10 CAV27715.1 - 0.006 16.6 0.7 0.023 14.7 0.7 1.8 1 1 1 2 2 2 1 Phage tail tube protein KOW PF00467.29 CAV27715.1 - 0.11 12.5 0.2 0.2 11.7 0.2 1.5 1 0 0 1 1 1 0 KOW motif DUF4150 PF13665.6 CAV27717.1 - 3.8e-34 117.1 1.6 8.1e-34 116.0 1.6 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4150) PAAR_motif PF05488.13 CAV27717.1 - 0.0053 16.9 0.7 0.14 12.4 0.1 2.8 3 0 0 3 3 3 1 PAAR motif Ribosomal_S30AE PF02482.19 CAV27717.1 - 0.084 13.7 0.7 1.5 9.6 0.0 3.1 3 0 0 3 3 3 0 Sigma 54 modulation protein / S30EA ribosomal protein AHH PF14412.6 CAV27719.1 - 1.5e-18 66.9 1.4 2.1e-18 66.5 1.4 1.2 1 0 0 1 1 1 1 A nuclease family of the HNH/ENDO VII superfamily with conserved AHH Gp45_2 PF17470.2 CAV27721.1 - 0.14 12.1 2.1 0.2 11.6 0.1 2.2 2 1 1 3 3 3 0 Phage gene product 45.2 Imm41 PF15592.6 CAV27723.1 - 0.0069 16.7 0.1 0.017 15.4 0.1 1.8 1 1 0 1 1 1 1 Immunity protein 41 CopG_antitoxin PF12441.8 CAV27723.1 - 0.047 14.2 0.4 0.14 12.8 0.1 1.9 2 0 0 2 2 2 0 CopG antitoxin of type II toxin-antitoxin system AA_kinase PF00696.28 CAV27726.1 - 1.5e-23 83.7 0.0 2.6e-23 82.9 0.0 1.3 1 1 0 1 1 1 1 Amino acid kinase family SKI PF01202.22 CAV27726.1 - 0.16 12.0 0.7 0.87 9.7 0.1 2.5 3 1 1 4 4 4 0 Shikimate kinase GST_N PF02798.20 CAV27728.1 - 1.2e-12 48.0 0.0 2.9e-12 46.8 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 CAV27728.1 - 1.3e-12 48.0 0.0 3.1e-12 46.7 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 CAV27728.1 - 6.6e-11 42.3 0.0 1.1e-10 41.6 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 CAV27728.1 - 0.013 15.5 0.0 0.03 14.4 0.0 1.6 1 1 0 1 1 1 0 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 CAV27728.1 - 0.04 14.1 0.0 0.14 12.3 0.0 1.8 2 0 0 2 2 2 0 Glutathione S-transferase, C-terminal domain FAA_hydrolase PF01557.18 CAV27730.1 - 2.8e-39 135.1 0.0 3.7e-39 134.6 0.0 1.1 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family FAA_hydro_N_2 PF18288.1 CAV27730.1 - 1.7e-30 105.2 0.0 4e-30 104.0 0.0 1.7 1 0 0 1 1 1 1 Fumarylacetoacetase N-terminal domain 2 HgmA PF04209.13 CAV27732.1 - 1.1e-21 77.0 1.0 1.4e-21 76.7 1.0 1.1 1 0 0 1 1 1 1 homogentisate 1,2-dioxygenase Cupin_2 PF07883.11 CAV27732.1 - 0.00041 20.0 0.4 0.0081 15.9 0.0 3.2 3 1 0 3 3 3 1 Cupin domain AraC_binding PF02311.19 CAV27732.1 - 0.021 14.8 0.0 0.047 13.6 0.0 1.6 1 0 0 1 1 1 0 AraC-like ligand binding domain Glyoxalase_5 PF14696.6 CAV27734.1 - 2.3e-56 189.8 0.0 2.1e-55 186.7 0.1 2.0 2 0 0 2 2 2 1 Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal Glyoxalase PF00903.25 CAV27734.1 - 3.9e-14 53.0 0.1 3.6e-13 49.8 0.0 2.1 2 0 0 2 2 2 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_4 PF13669.6 CAV27734.1 - 1.8e-09 37.8 0.0 2.1e-06 27.9 0.0 2.4 2 0 0 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_3 PF13468.6 CAV27734.1 - 0.003 17.7 0.0 0.089 12.9 0.0 2.5 3 0 0 3 3 3 1 Glyoxalase-like domain DUF1338 PF07063.13 CAV27734.1 - 0.11 11.7 0.0 1.8 7.7 0.0 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF1338) HAD PF12710.7 CAV27737.1 - 1.9e-26 93.7 0.0 2.1e-26 93.5 0.0 1.0 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 CAV27737.1 - 0.022 14.8 0.4 0.056 13.5 0.3 1.7 2 1 0 2 2 2 0 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 CAV27737.1 - 0.066 13.5 0.0 0.76 10.0 0.0 2.0 1 1 0 1 1 1 0 haloacid dehalogenase-like hydrolase RHH_6 PF16762.5 CAV27737.1 - 0.18 12.4 0.1 0.37 11.4 0.1 1.4 1 0 0 1 1 1 0 Ribbon-helix-helix domain Response_reg PF00072.24 CAV27738.1 - 2e-42 143.8 1.0 2.6e-24 85.6 0.4 2.8 2 0 0 2 2 2 2 Response regulator receiver domain HATPase_c PF02518.26 CAV27738.1 - 1.3e-29 103.0 0.3 4.4e-29 101.3 0.3 2.0 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 CAV27738.1 - 2.3e-18 66.0 0.1 7e-18 64.4 0.1 1.9 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain CHASE5 PF17149.4 CAV27738.1 - 5.1e-11 42.4 0.2 3.7e-10 39.7 0.0 2.4 2 0 0 2 2 2 1 Periplasmic sensor domain found in signal transduction proteins FleQ PF06490.11 CAV27738.1 - 0.00019 21.8 0.6 0.24 11.8 0.0 3.7 3 0 0 3 3 3 1 Flagellar regulatory protein FleQ DUF1828 PF08861.10 CAV27738.1 - 0.11 12.7 0.2 21 5.5 0.0 3.1 2 0 0 2 2 2 0 Domain of unknown function DUF1828 SBP_bac_3 PF00497.20 CAV27740.1 - 3.1e-12 46.4 0.0 4.8e-12 45.8 0.0 1.3 1 1 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 TctC PF03401.14 CAV27740.1 - 0.0031 16.6 0.0 0.0046 16.1 0.0 1.2 1 0 0 1 1 1 1 Tripartite tricarboxylate transporter family receptor Transferrin PF00405.17 CAV27740.1 - 0.2 10.8 0.0 0.3 10.2 0.0 1.2 1 0 0 1 1 1 0 Transferrin DUF1768 PF08719.11 CAV27742.1 - 1.2e-33 116.7 0.0 1.5e-33 116.3 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1768) Phage_30_3 PF08010.11 CAV27742.1 - 0.039 13.7 0.0 0.4 10.5 0.0 2.4 2 1 0 2 2 2 0 Bacteriophage protein GP30.3 ABC_tran PF00005.27 CAV27745.1 - 2.4e-28 99.4 0.0 4e-28 98.6 0.0 1.4 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 CAV27745.1 - 2.3e-07 30.9 3.8 1.7e-06 28.0 0.7 2.1 1 1 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system oligo_HPY PF08352.12 CAV27745.1 - 6e-05 23.5 0.0 0.00013 22.4 0.0 1.6 1 0 0 1 1 1 1 Oligopeptide/dipeptide transporter, C-terminal region SMC_N PF02463.19 CAV27745.1 - 0.00071 19.1 1.4 0.0049 16.3 1.4 2.0 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 CAV27745.1 - 0.0062 16.2 0.0 0.012 15.3 0.0 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA PF00004.29 CAV27745.1 - 0.0076 16.7 0.0 0.032 14.6 0.0 2.0 1 1 1 2 2 2 1 ATPase family associated with various cellular activities (AAA) ABC_ATPase PF09818.9 CAV27745.1 - 0.011 14.5 0.1 0.053 12.3 0.0 2.1 2 1 0 2 2 2 0 Predicted ATPase of the ABC class AAA_22 PF13401.6 CAV27745.1 - 0.012 15.8 1.5 0.31 11.3 1.5 2.3 1 1 0 1 1 1 0 AAA domain TniB PF05621.11 CAV27745.1 - 0.014 14.8 0.7 0.57 9.6 0.2 2.5 2 1 0 2 2 2 0 Bacterial TniB protein AAA_16 PF13191.6 CAV27745.1 - 0.024 15.0 0.0 0.037 14.4 0.0 1.5 1 1 0 1 1 1 0 AAA ATPase domain G-alpha PF00503.20 CAV27745.1 - 0.043 13.0 0.0 0.058 12.5 0.0 1.3 1 0 0 1 1 1 0 G-protein alpha subunit RsgA_GTPase PF03193.16 CAV27745.1 - 0.063 13.2 0.0 0.25 11.3 0.0 1.8 2 0 0 2 2 2 0 RsgA GTPase PRK PF00485.18 CAV27745.1 - 0.073 12.8 0.0 0.097 12.4 0.0 1.4 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family NB-ARC PF00931.22 CAV27745.1 - 0.073 12.2 0.0 0.5 9.5 0.0 2.2 3 0 0 3 3 3 0 NB-ARC domain AAA_25 PF13481.6 CAV27745.1 - 0.1 12.2 0.5 3.4 7.2 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_23 PF13476.6 CAV27745.1 - 0.12 12.9 0.4 0.27 11.7 0.4 1.5 1 0 0 1 1 1 0 AAA domain ATPase PF06745.13 CAV27745.1 - 0.21 10.9 0.5 4.7 6.5 0.1 2.1 2 0 0 2 2 2 0 KaiC ABC_tran PF00005.27 CAV27747.1 - 5.1e-34 117.7 0.0 9.8e-34 116.8 0.0 1.5 2 0 0 2 2 2 1 ABC transporter oligo_HPY PF08352.12 CAV27747.1 - 2.7e-08 34.2 0.0 5.1e-08 33.3 0.0 1.5 1 0 0 1 1 1 1 Oligopeptide/dipeptide transporter, C-terminal region AAA_16 PF13191.6 CAV27747.1 - 0.0014 19.0 0.0 0.003 17.9 0.0 1.4 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 CAV27747.1 - 0.0014 18.9 0.6 0.0054 17.0 0.6 2.0 1 1 0 1 1 1 1 AAA domain AAA_29 PF13555.6 CAV27747.1 - 0.0074 16.0 0.0 0.027 14.2 0.0 1.8 2 0 0 2 2 2 1 P-loop containing region of AAA domain G-alpha PF00503.20 CAV27747.1 - 0.0099 15.1 0.0 0.012 14.8 0.0 1.3 1 1 0 1 1 1 1 G-protein alpha subunit AAA PF00004.29 CAV27747.1 - 0.012 16.1 0.0 1.6 9.2 0.0 2.3 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Mg_chelatase PF01078.21 CAV27747.1 - 0.012 15.0 0.0 0.037 13.4 0.0 1.8 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 CAV27747.1 - 0.028 14.4 0.1 0.063 13.3 0.0 1.7 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) Rad17 PF03215.15 CAV27747.1 - 0.038 13.9 0.0 0.055 13.4 0.0 1.3 1 0 0 1 1 1 0 Rad17 P-loop domain RsgA_GTPase PF03193.16 CAV27747.1 - 0.058 13.3 0.0 0.11 12.4 0.0 1.4 1 0 0 1 1 1 0 RsgA GTPase Sigma54_activ_2 PF14532.6 CAV27747.1 - 0.085 13.0 0.1 0.23 11.6 0.0 1.8 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_24 PF13479.6 CAV27747.1 - 0.1 12.3 0.0 0.16 11.7 0.0 1.3 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 CAV27747.1 - 0.12 12.8 0.0 0.21 12.0 0.0 1.5 1 0 0 1 1 1 0 RNA helicase AAA_23 PF13476.6 CAV27747.1 - 0.13 12.8 0.1 0.28 11.7 0.1 1.9 1 1 0 1 1 1 0 AAA domain PRK PF00485.18 CAV27747.1 - 0.13 12.0 0.0 0.23 11.1 0.0 1.4 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family DUF3346 PF11826.8 CAV27752.1 - 1.1e-138 460.3 1.2 2e-138 459.6 0.5 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF3346) HTH_55 PF18622.1 CAV27752.1 - 1.7e-63 211.7 0.1 3.7e-63 210.6 0.1 1.6 1 0 0 1 1 1 1 RctB helix turn helix domain # # Program: hmmscan # Version: 3.2.1 (June 2018) # Pipeline mode: SCAN # Query file: /oak/stanford/groups/akundaje/marinovg/genomes/Bacteria/Vibrio_tasmaniensis_LGP32-ASM9146v1/GCA_000091465.1_ASM9146v1_protein.faa # Target file: /oak/stanford/groups/akundaje/marinovg/genomes/PFam/PFam32.0/Pfam-A.hmm # Option settings: /oak/stanford/groups/akundaje/marinovg/programs/hmmer-3.2.1/bin/hmmscan -o /oak/stanford/groups/akundaje/marinovg/genomes/Bacteria/Vibrio_tasmaniensis_LGP32-ASM9146v1/GCA_000091465.1_ASM9146v1_protein.PFam32-A --tblout /oak/stanford/groups/akundaje/marinovg/genomes/Bacteria/Vibrio_tasmaniensis_LGP32-ASM9146v1/GCA_000091465.1_ASM9146v1_protein.PFam32-A.tblout --cpu 20 /oak/stanford/groups/akundaje/marinovg/genomes/PFam/PFam32.0/Pfam-A.hmm /oak/stanford/groups/akundaje/marinovg/genomes/Bacteria/Vibrio_tasmaniensis_LGP32-ASM9146v1/GCA_000091465.1_ASM9146v1_protein.faa # Current dir: /oak/stanford/groups/akundaje/marinovg/genomes # Date: Sun Mar 24 04:40:04 2019 # [ok]